Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	G	C	tCw	wGa	tC	Ga	tC_mutation	tC_mutation_to_G	tC_mutation_to_T	APOBEC_mutation	APOBEC_mutation_to_G	APOBEC_mutation_to_T	"CONTEXT(+/-20)"	g_counts	c_counts	tcw_counts	wga_counts	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	newbase	end	tum_allele1	tum_allele2	start	effect_idx	newbase_idx	pat_idx	is_coding	is_flank	is_indel	is_ins	is_del	is_missense	is_nonsense	is_splice	is_silent	gene_idx	context_and_effect	context65	categ_idx	trackpos	categ	gene	chr	pos	type	classification	ref_allele	patient	DistBetween_Mutations	Distance_to_LT_end	Distance_to_RT_end	Strain_Mutation_ID	Dataset_Mutation_ID	Complex_ID	Complex_Size	StrainCluster_ID	Dataset_Cluster_ID	Distance_Between_Clusters	Cluster_Size_Mutations	Cluster_Size_Complexes	Cluster_Length	Cluster_Coordination	Content_of_non_coordinated_cluster	Cluster_Pvalue
ATAD3B	83858	broad.mit.edu	37	chr1	1430871	1430871	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctctcttcactaggccacgGcatatgcctccaaggacggg	10	14	3	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr1:1430871G>A	uc001afv.2	+	16	1722	c.1621G>A	c.(1621-1623)GCA>ACA	p.A541T	ATAD3B_uc001afx.2_Missense_Mutation_p.A495T|ATAD3B_uc001afy.2_Missense_Mutation_p.A94T	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	541							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CTAGGCCACGGCATATGCCTC	0.632													A	1430871	A	A	1430871	3	1	1	1	0	0	0	0	1	0	0	0	1074	1203	42	3	1683	3	ATAD3B	1	1430871	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08		1430871	247819750	1	1											
TPM3	7170	broad.mit.edu	37	chr1	154148652	154148652	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcagggcagtggccaggcGctcctgagcacggtccagct	15	13	0	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr1:154148652G>A	uc001fec.1	-	3	431	c.316C>T	c.(316-318)CGC>TGC	p.R106C	TPM3_uc010pei.1_Intron|TPM3_uc001fdy.1_Missense_Mutation_p.R69C|TPM3_uc001fdz.1_Missense_Mutation_p.R69C|TPM3_uc001fea.1_Missense_Mutation_p.R69C|TPM3_uc001feb.1_Missense_Mutation_p.R69C|TPM3_uc010pej.1_Intron|TPM3_uc009wor.2_Intron|TPM3_uc001fed.1_Missense_Mutation_p.R69C	NM_152263	NP_689476	P06753	TPM3_HUMAN	tropomyosin 3 isoform 1	105	By similarity.				cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/ALK(33)	haematopoietic_and_lymphoid_tissue(22)|soft_tissue(11)|skin(1)	34	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					GTGGCCAGGCGCTCCTGAGCA	0.527			T	NTRK1|ALK	papillary thyroid|ALCL								A	154148652	A	A	154148652	3	1	1	1	0	0	0	0	1	0	0	0	16404	1087	38	1	824	1	TPM3	1	154148652	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	152717781	154148652	95101969	2	2											
NR1I3	9970	broad.mit.edu	37	chr1	161206281	161206281	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgcagccctcacaagtcagCgcattaaagtggtagcctgt	10	11	2	0	rs140012276	byFrequency	TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr1:161206281C>T	uc001fzx.2	-	2	278	c.75G>A	c.(73-75)GCG>GCA	p.A25A	TOMM40L_uc009wuf.1_Intron|NR1I3_uc001fzf.2_Silent_p.A25A|NR1I3_uc001fzg.2_Intron|NR1I3_uc001fzh.2_Intron|NR1I3_uc001fzi.2_Intron|NR1I3_uc001fzj.2_Intron|NR1I3_uc001fzk.2_Intron|NR1I3_uc001fzl.2_Intron|NR1I3_uc001fzm.2_Intron|NR1I3_uc001fzn.2_5'UTR|NR1I3_uc009wug.2_Intron|NR1I3_uc001fzp.2_Silent_p.A25A|NR1I3_uc001fzo.2_Intron|NR1I3_uc001fzq.2_Silent_p.A25A|NR1I3_uc001fzr.2_Silent_p.A25A|NR1I3_uc001fzs.2_Intron|NR1I3_uc001fzt.2_Intron|NR1I3_uc001fzu.2_Intron|NR1I3_uc001fzv.2_Intron|NR1I3_uc001fzw.2_Silent_p.A25A|NR1I3_uc001fzy.2_Silent_p.A25A|NR1I3_uc001fzz.2_Silent_p.A25A|NR1I3_uc001gaa.2_Silent_p.A25A|NR1I3_uc001gab.2_Silent_p.A25A|NR1I3_uc001gac.2_Intron|NR1I3_uc010pkm.1_Intron|NR1I3_uc010pkn.1_Silent_p.A25A	NM_001077480	NP_001070948	Q14994	NR1I3_HUMAN	constitutive androstane receptor isoform 2	25	NR C4-type.|Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(1)|skin(1)	2	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CACAAGTCAGCGCATTAAAGT	0.532													T	161206281	T	T	161206281	2	4	1	1	0	0	0	0	0	0	0	1	10621	755	27	1		1	NR1I3	1	161206281	Silent	SNP	C	TCGA-02-0003-01A-01D-1490-08	7057629	161206281	88044340	3	3											
AGT	183	broad.mit.edu	37	chr1	230846235	230846235	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccacgccccatagctcactgTgcatgccatatatacggaag	8	14	1	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr1:230846235T>A	uc001hty.3	-	2	870	c.362A>T	c.(361-363)CAC>CTC	p.H121L	AGT_uc009xfe.2_Missense_Mutation_p.H121L|AGT_uc009xff.2_Missense_Mutation_p.H93L	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	121					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	TAGCTCACTGTGCATGCCATA	0.582													A	230846235	A	A	230846235	3	1	1	1	0	0	0	0	1	0	0	0	399	1696	59	5	1111	5	AGT	1	230846235	Missense_Mutation	SNP	T	TCGA-02-0003-01A-01D-1490-08	69639954	230846235	18404386	4	4											
C2orf63	130162	broad.mit.edu	37	chr2	55439915	55439915	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tctatttgagattgaatcttCgaggaattactttcgataat	7	5	2	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr2:55439915C>A	uc002ryi.2	-	5	739	c.393G>T	c.(391-393)TCG>TCT	p.S131S	C2orf63_uc002ryh.2_Intron|C2orf63_uc002ryj.2_Silent_p.S9S	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	131							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)			ATTGAATCTTCGAGGAATTAC	0.338													A	55439915	A	A	55439915	2	1	1	1	0	0	0	0	0	0	0	1	2182	871	31	5		5	C2orf63	2	55439915	Silent	SNP	C	TCGA-02-0003-01A-01D-1490-08		55439915	187759458	5	5											
ALMS1	7840	broad.mit.edu	37	chr2	73680365	73680365	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttgtaataaataaaccagaAtctgcaggttttagagatgt	9	4	1	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr2:73680365A>G	uc002sje.1	+	10	6825	c.6714A>G	c.(6712-6714)GAA>GAG	p.E2238E	ALMS1_uc002sjf.1_Silent_p.E2194E|ALMS1_uc002sjg.2_Silent_p.E1624E|ALMS1_uc002sjh.1_Silent_p.E1624E	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2236					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						ATAAACCAGAATCTGCAGGTT	0.363													G	73680365	G	G	73680365	2	3	1	1	0	0	0	0	0	0	0	1	535	98	4	4		4	ALMS1	2	73680365	Silent	SNP	A	TCGA-02-0003-01A-01D-1490-08	18240450	73680365	169519008	6	6											
PLCL1	5334	broad.mit.edu	37	chr2	198950756	198950756	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggtgacatcatggagcacGtaaccctttttgtccacata	9	10	1	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr2:198950756G>A	uc010fsp.2	+	2	2806	c.2515G>A	c.(2515-2517)GTA>ATA	p.V839I	PLCL1_uc002uuv.3_Missense_Mutation_p.V760I	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	839					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CATGGAGCACGTAACCCTTTT	0.453													A	198950756	A	A	198950756	3	1	1	1	0	0	0	0	1	0	0	0	12039	1145	40	1	2521	1	PLCL1	2	198950756	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	125270391	198950756	44248617	7	7											
SLC11A1	6556	broad.mit.edu	37	chr2	219255987	219255987	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccccatgaacaacgccaccGtggccgtggacatttaccag	9	15	0	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr2:219255987G>A	uc002vhv.2	+	10	1361	c.1021G>A	c.(1021-1023)GTG>ATG	p.V341M	SLC11A1_uc010fvp.1_Missense_Mutation_p.V341M|SLC11A1_uc010fvq.1_Missense_Mutation_p.V274M|SLC11A1_uc010zkc.1_Missense_Mutation_p.V274M|SLC11A1_uc002vhu.1_Missense_Mutation_p.V136M|SLC11A1_uc002vhw.2_Missense_Mutation_p.V223M|SLC11A1_uc010fvr.2_Missense_Mutation_p.V136M	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	341	Extracellular (Potential).				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAACGCCACCGTGGCCGTGGA	0.627													A	219255987	A	A	219255987	3	1	1	1	0	0	0	0	1	0	0	0	14380	1145	40	1	1059	1	SLC11A1	2	219255987	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	20305231	219255987	23943386	8	8											
OBSL1	23363	broad.mit.edu	37	chr2	220422920	220422920	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acccaccagccaggatgacaTtgaaggtgatggcctcatgc	11	12	1	3			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr2:220422920T>C	uc010fwk.2	-	10	3545	c.3488A>G	c.(3487-3489)AAT>AGT	p.N1163S	OBSL1_uc002vmh.1_Missense_Mutation_p.N154S|OBSL1_uc010zli.1_Intron|OBSL1_uc010fwl.1_Missense_Mutation_p.N638S	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1163	Ig-like 9.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CAGGATGACATTGAAGGTGAT	0.657													C	220422920	C	C	220422920	3	2	1	1	0	0	0	0	1	0	0	0	10813	1493	52	4	2273	4	OBSL1	2	220422920	Missense_Mutation	SNP	T	TCGA-02-0003-01A-01D-1490-08	1166933	220422920	22776453	9	9											
CLEC3B	7123	broad.mit.edu	37	chr3	45077083	45077083	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccagacgaagaccttccaCgaggccagcgaggactgcat	11	14	0	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr3:45077083C>T	uc003cok.3	+	3	372	c.276C>T	c.(274-276)CAC>CAT	p.H92H	CLEC3B_uc003col.2_Silent_p.H50H	NM_003278	NP_003269	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	92	C-type lectin.				skeletal system development	extracellular space	protein binding|sugar binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGACCTTCCACGAGGCCAGCG	0.627													T	45077083	T	T	45077083	2	4	1	1	0	0	0	0	0	0	0	1	3511	535	19	1		1	CLEC3B	3	45077083	Silent	SNP	C	TCGA-02-0003-01A-01D-1490-08		45077083	152945347	10	10											
NPRL2	10641	broad.mit.edu	37	chr3	50387203	50387203	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgaagaggagagcattgcGgctgtacttcttgtgttcga	14	6	1	3			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr3:50387203G>A	uc003daj.1	-	3	635	c.232C>T	c.(232-234)CGC>TGC	p.R78C	NPRL2_uc003dai.1_5'UTR|CYB561D2_uc003dak.2_5'Flank|CYB561D2_uc003dal.2_5'Flank|CYB561D2_uc003dam.2_5'Flank	NM_006545	NP_006536	Q8WTW4	NPRL2_HUMAN	tumor suppressor candidate 4	78	Interaction with PDPK1.				negative regulation of kinase activity		protein binding|protein kinase activity			lung(1)	1						AGAGCATTGCGGCTGTACTTC	0.547													A	50387203	A	A	50387203	3	1	1	1	0	0	0	0	1	0	0	0	10597	1116	39	2	946	2	NPRL2	3	50387203	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	5310120	50387203	147635227	11	11											
DZIP1L	199221	broad.mit.edu	37	chr3	137796433	137796433	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggggttacgcctcagagCtgccagcaccttgtgctgtt	13	11	1	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr3:137796433C>T	uc003erq.2	-	11	1693	c.1330G>A	c.(1330-1332)GCT>ACT	p.A444T	DZIP1L_uc003err.1_Missense_Mutation_p.A444T	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	444						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						CGCCTCAGAGCTGCCAGCACC	0.537													T	137796433	T	T	137796433	3	4	1	1	0	0	0	0	1	0	0	0	4864	797	28	3	1006	3	DZIP1L	3	137796433	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08	87409230	137796433	60225997	12	12											
ANAPC4	29945	broad.mit.edu	37	chr4	25396471	25396471	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggcttgaaaaagcttggccaGtctatagagtcatcatactc	9	9	3	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr4:25396471G>T	uc003gro.2	+	14	1134	c.1005G>T	c.(1003-1005)CAG>CAT	p.Q335H	ANAPC4_uc003grp.2_Missense_Mutation_p.Q220H|ANAPC4_uc010iet.1_Missense_Mutation_p.Q115H|ANAPC4_uc010ieu.1_Intron	NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	anaphase-promoting complex subunit 4	335					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)				AGCTTGGCCAGTCTATAGAGT	0.313													T	25396471	T	T	25396471	3	4	1	1	0	0	0	0	1	0	0	0	604	1020	36	5	1055	5	ANAPC4	4	25396471	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08		25396471	165757805	13	13											
UGT2B28	54490	broad.mit.edu	37	chr4	70156391	70156391	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctaccatgggatccctatggTaggcattccattgttttggg	11	9	0	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr4:70156391T>C	uc003hej.2	+	5	1174	c.1172T>C	c.(1171-1173)GTA>GCA	p.V391A	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	391					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	ATCCCTATGGTAGGCATTCCA	0.448													C	70156391	C	C	70156391	3	2	1	1	0	0	0	0	1	0	0	0	16957	1638	57	4	1190	4	UGT2B28	4	70156391	Missense_Mutation	SNP	T	TCGA-02-0003-01A-01D-1490-08	44759920	70156391	120997885	14	14											
DNAH5	1767	broad.mit.edu	37	chr5	13727709	13727709	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggcatttggaagaggttcCtcctccgggttttccttatc	10	10	0	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr5:13727709C>T	uc003jfd.2	-	70	11982	c.11940G>A	c.(11938-11940)GAG>GAA	p.E3980E	DNAH5_uc003jfc.2_Silent_p.E148E	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3980					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GAAGAGGTTCCTCCTCCGGGT	0.413									Kartagener_syndrome				T	13727709	T	T	13727709	2	4	1	1	0	0	0	0	0	0	0	1	4604	680	24	3		3	DNAH5	5	13727709	Silent	SNP	C	TCGA-02-0003-01A-01D-1490-08		13727709	167187551	15	15											
PIK3R1	5295	broad.mit.edu	37	chr5	67589138	67589138	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attgtttttacaggaaagggGgaaataacaaattaatcaaa	8	3	1	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr5:67589138G>A	uc003jva.2	+	10	1686	c.1126G>A	c.(1126-1128)GGA>AGA	p.G376R	PIK3R1_uc003jvb.2_Missense_Mutation_p.G376R|PIK3R1_uc003jvc.2_Missense_Mutation_p.G76R|PIK3R1_uc003jvd.2_Missense_Mutation_p.G106R|PIK3R1_uc003jve.2_Missense_Mutation_p.G55R|PIK3R1_uc011crb.1_Missense_Mutation_p.G46R	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	376	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.G376R(3)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CAGGAAAGGGGGAAATAACAA	0.308			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			A	67589138	A	A	67589138	3	1	1	1	0	0	0	0	1	0	0	0	11918	1233	43	3	1290	3	PIK3R1	5	67589138	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	53861429	67589138	113326122	16	16											
MTX3	345778	broad.mit.edu	37	chr5	79284349	79284349	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggtcaggagaatcctattcAgtgctcccttagacattctt	8	10	3	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr5:79284349A>T	uc010jag.2	-	5	467	c.440T>A	c.(439-441)CTG>CAG	p.L147Q	MTX3_uc010jah.2_Missense_Mutation_p.L147Q|MTX3_uc003kge.3_Missense_Mutation_p.L86Q|MTX3_uc003kgf.1_5'Flank	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	147					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		AATCCTATTCAGTGCTCCCTT	0.463													T	79284349	T	T	79284349	3	4	1	1	0	0	0	0	1	0	0	0	9969	188	7	5	518	5	MTX3	5	79284349	Missense_Mutation	SNP	A	TCGA-02-0003-01A-01D-1490-08	11695211	79284349	101630911	17	17											
HRH2	3274	broad.mit.edu	37	chr5	175110351	175110351	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgttgctggcaatgtggtcGtctgtctggccgtgggcttg	16	10	2	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr5:175110351G>A	uc003mdd.2	+	1	1888	c.115G>A	c.(115-117)GTC>ATC	p.V39I	HRH2_uc003mdc.3_Missense_Mutation_p.V39I	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	39	Helical; Name=1; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CAATGTGGTCGTCTGTCTGGC	0.582													A	175110351	A	A	175110351	3	1	1	1	0	0	0	0	1	0	0	0	7356	1145	40	1	117	1	HRH2	5	175110351	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	95826002	175110351	5804909	18	18											
KIAA0319	9856	broad.mit.edu	37	chr6	24556864	24556864	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctctccatcccagatataaCgctgtataaggttctccatc	5	13	2	1	rs137950263		TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr6:24556864C>T	uc011djo.1	-	18	3065	c.2828G>A	c.(2827-2829)CGT>CAT	p.R943H	KIAA0319_uc011djp.1_Missense_Mutation_p.R898H|KIAA0319_uc003neh.1_Missense_Mutation_p.R943H|KIAA0319_uc011djq.1_Missense_Mutation_p.R934H|KIAA0319_uc011djr.1_Missense_Mutation_p.R943H|KIAA0319_uc010jpt.1_Missense_Mutation_p.R354H	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	943	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CCAGATATAACGCTGTATAAG	0.488													T	24556864	T	T	24556864	3	4	1	1	0	0	0	0	1	0	0	0	8168	536	19	1	406	1	KIAA0319	6	24556864	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08		24556864	146558203	19	19											
SLC39A7	7922	broad.mit.edu	37	chr6	33170112	33170112	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctttcttgtcgtggagaaatTtgtgagacatgtgaaaggag	13	4	1	3			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr6:33170112T>C	uc003odf.2	+	5	824	c.707T>C	c.(706-708)TTT>TCT	p.F236S	RXRB_uc003odb.2_5'Flank|RXRB_uc003odc.2_5'Flank|RXRB_uc003odd.2_5'Flank|RXRB_uc011dqr.1_5'Flank|RXRB_uc011dqs.1_5'Flank|RXRB_uc011dqt.1_5'Flank|RXRB_uc011dqu.1_5'Flank|SLC39A7_uc003odg.2_Missense_Mutation_p.F236S|SLC39A7_uc011dqv.1_Missense_Mutation_p.F111S|SLC39A7_uc003odh.2_5'UTR|HSD17B8_uc003odi.1_5'Flank	NM_001077516	NP_001070984	Q92504	S39A7_HUMAN	solute carrier family 39, member 7	236						endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			large_intestine(1)	1						GTGGAGAAATTTGTGAGACAT	0.507													C	33170112	C	C	33170112	3	2	1	1	0	0	0	0	1	0	0	0	14623	1841	64	4	721	4	SLC39A7	6	33170112	Missense_Mutation	SNP	T	TCGA-02-0003-01A-01D-1490-08	8613248	33170112	137944955	20	20											
EPHA7	2045	broad.mit.edu	37	chr6	94120845	94120845	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttggcacacctggtatgttCgtatcggggtatagttctca	11	9	1	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr6:94120845C>T	uc003poe.2	-	3	447	c.206G>A	c.(205-207)CGA>CAA	p.R69Q	EPHA7_uc003pof.2_Missense_Mutation_p.R69Q|EPHA7_uc011eac.1_Missense_Mutation_p.R69Q|EPHA7_uc003pog.3_Missense_Mutation_p.R69Q	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	69	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.R69Q(1)		lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CTGGTATGTTCGTATCGGGGT	0.393													T	94120845	T	T	94120845	3	4	1	1	0	0	0	0	1	0	0	0	5172	884	31	2	2850	2	EPHA7	6	94120845	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08	60950733	94120845	76994222	21	21											
SHPRH	257218	broad.mit.edu	37	chr6	146269445	146269445	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atagtagagtttcagaccctCagatgtaacaatctctcgcc	7	11	3	3			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr6:146269445C>T	uc003qlf.2	-	5	1423	c.1024G>A	c.(1024-1026)GAG>AAG	p.E342K	SHPRH_uc003qld.2_Missense_Mutation_p.E342K|SHPRH_uc003qle.2_Missense_Mutation_p.E342K|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Missense_Mutation_p.E231K|SHPRH_uc003qlk.1_Missense_Mutation_p.E342K	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	342	Helicase ATP-binding; first part.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TTCAGACCCTCAGATGTAACA	0.308													T	146269445	T	T	146269445	3	4	1	1	0	0	0	0	1	0	0	0	14291	835	29	3	4175	3	SHPRH	6	146269445	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08	52148600	146269445	24845622	22	22											
ELMO1	9844	broad.mit.edu	37	chr7	37251095	37251095	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	agcatcaaaagcaattcttcGaagttcaaatatgatgtccc	6	9	3	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr7:37251095G>C	uc003tfk.1	-	13	1289	c.982C>G	c.(982-984)CGA>GGA	p.R328G	ELMO1_uc011kbc.1_Missense_Mutation_p.R232G|ELMO1_uc010kxg.1_Missense_Mutation_p.R328G	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	328	ELMO.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GCAATTCTTCGAAGTTCAAAT	0.428													C	37251095	C	C	37251095	3	2	1	1	0	0	0	0	1	0	0	0	5065	1066	37	5	1241	5	ELMO1	7	37251095	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08		37251095	121887568	23	23											
EGFR	1956	broad.mit.edu	37	chr7	55233109	55233109	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggccatgtgtgccacctgtGccatccaaactgcacctacg	9	16	0	0	rs150899403		TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr7:55233109G>A	uc003tqk.2	+	15	2105	c.1859G>A	c.(1858-1860)TGC>TAC	p.C620Y	EGFR_uc003tqi.2_Missense_Mutation_p.C620Y|EGFR_uc003tqj.2_Missense_Mutation_p.C620Y|EGFR_uc010kzg.1_Missense_Mutation_p.C575Y|EGFR_uc011kco.1_Missense_Mutation_p.C567Y|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	620	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.C620Y(1)|p.C620W(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCACCTGTGCCATCCAAAC	0.542		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55233109	A	A	55233109	3	1	1	1	0	0	0	0	1	0	0	0	4967	1319	46	3	1928	3	EGFR	7	55233109	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	17982014	55233109	103905554	24	24											
ZNF680	340252	broad.mit.edu	37	chr7	64004766	64004766	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtccaggcattgccactcCtccagagagaattctatggc	10	12	1	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr7:64004766C>T	uc003tta.2	-	2	248	c.75G>A	c.(73-75)GAG>GAA	p.E25E	ZNF680_uc010kzr.2_5'UTR|ZNF680_uc003ttb.2_Silent_p.E25E	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				ATTGCCACTCCTCCAGAGAGA	0.343													T	64004766	T	T	64004766	2	4	1	1	0	0	0	0	0	0	0	1	18084	680	24	3		3	ZNF680	7	64004766	Silent	SNP	C	TCGA-02-0003-01A-01D-1490-08	8771657	64004766	95133897	25	25											
AUTS2	26053	broad.mit.edu	37	chr7	70255710	70255710	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcacacgcggctccactccGtgcaccccgcctccctcgac	8	22	0	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr7:70255710G>A	uc003tvw.3	+	19	4251	c.3508G>A	c.(3508-3510)GTG>ATG	p.V1170M	AUTS2_uc003tvx.3_Missense_Mutation_p.V1146M|AUTS2_uc011keg.1_Missense_Mutation_p.V622M	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1170	His-rich.									ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GCTCCACTCCGTGCACCCCGC	0.697													A	70255710	A	A	70255710	3	1	1	1	0	0	0	0	1	0	0	0	1225	1145	40	1	3727	1	AUTS2	7	70255710	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	6250944	70255710	88882953	26	26											
MUC17	140453	broad.mit.edu	37	chr7	100677039	100677039	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aagcacacatatcaccacttCtactgaagccagttgctctc	5	14	3	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr7:100677039C>T	uc003uxp.1	+	3	2395	c.2342C>T	c.(2341-2343)TCT>TTT	p.S781F	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	781	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|11.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ATCACCACTTCTACTGAAGCC	0.458													T	100677039	T	T	100677039	3	4	1	1	0	0	0	0	1	0	0	0	9974	913	32	3	2352	3	MUC17	7	100677039	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08	30421329	100677039	58461624	27	27											
SLC26A3	1811	broad.mit.edu	37	chr7	107431527	107431527	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaagcactgtgactgatgccGccgccgccaccctcaccctc	8	19	1	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr7:107431527G>A	uc003ver.2	-	5	747	c.536C>T	c.(535-537)GCG>GTG	p.A179V	SLC26A3_uc003ves.2_Missense_Mutation_p.A144V	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	179	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						GACTGATGCCGCCGCCGCCAC	0.483													A	107431527	A	A	107431527	3	1	1	1	0	0	0	0	1	0	0	0	14518	1087	38	1	1826	1	SLC26A3	7	107431527	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	6754488	107431527	51707136	28	28											
POTEA	340441	broad.mit.edu	37	chr8	43147808	43147808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacggagccaaggtatcacGtccgtcgagaagatctgggc	13	11	3	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr8:43147808G>A	uc003xpz.1	+	1	224	c.181G>A	c.(181-183)GTC>ATC	p.V61I	POTEA_uc003xqa.1_Missense_Mutation_p.V61I	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	61										ovary(1)	1						AAGGTATCACGTCCGTCGAGA	0.602													A	43147808	A	A	43147808	3	1	1	1	0	0	0	0	1	0	0	0	12261	1145	40	1	183	1	POTEA	8	43147808	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08		43147808	103216214	29	29											
UBR5	51366	broad.mit.edu	37	chr8	103282370	103282370	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gattcccttcagaggctggtCtaaagggcctagtgtcgatg	13	9	2	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr8:103282370C>A	uc003ykr.1	-	50	7160	c.7127G>T	c.(7126-7128)AGA>ATA	p.R2376I	UBR5_uc003yks.1_Missense_Mutation_p.R2376I|UBR5_uc003ykq.2_5'Flank	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2376					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AGAGGCTGGTCTAAAGGGCCT	0.438													A	103282370	A	A	103282370	3	1	1	1	0	0	0	0	1	0	0	0	16902	913	32	5	1312	5	UBR5	8	103282370	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08	60134562	103282370	43081652	30	30											
KIAA0020	9933	broad.mit.edu	37	chr9	2811564	2811564	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctaggagctcccgtctgcGgacctctgtatctttcttac	8	13	5	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr9:2811564G>A	uc003zhp.1	-	15	1528	c.1432C>T	c.(1432-1434)CGC>TGC	p.R478C	KIAA0020_uc010mhc.1_Missense_Mutation_p.R477C|KIAA0020_uc003zhq.1_Missense_Mutation_p.R477C	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	478	PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		TCCCGTCTGCGGACCTCTGTA	0.433													A	2811564	A	A	2811564	3	1	1	1	0	0	0	0	1	0	0	0	8152	1116	39	2	530	2	KIAA0020	9	2811564	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08		2811564	138401867	31	31											
KIF27	55582	broad.mit.edu	37	chr9	86482718	86482718	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctcctctaattcttggcGttggttcagaactttctcta	7	11	4	1	rs3199677	by1000genomes	TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr9:86482718G>A	uc004ana.2	-	13	2959	c.2815C>T	c.(2815-2817)CGC>TGC	p.R939C	KIF27_uc010mpw.2_Missense_Mutation_p.R873C|KIF27_uc010mpx.2_Intron	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	939	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						AATTCTTGGCGTTGGTTCAGA	0.373													A	86482718	A	A	86482718	3	1	1	1	0	0	0	0	1	0	0	0	8296	1145	40	1	1414	1	KIF27	9	86482718	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	83671154	86482718	54730713	32	32											
TACC2	10579	broad.mit.edu	37	chr10	123810032	123810032	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaaggaagcagcaggacaCgcccggaagccctgaccaca	11	13	0	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr10:123810032C>T	uc001lfv.2	+	3	473	c.113C>T	c.(112-114)ACG>ATG	p.T38M	TACC2_uc001lfw.2_Missense_Mutation_p.T38M|TACC2_uc009xzx.2_Missense_Mutation_p.T38M|TACC2_uc010qtv.1_Missense_Mutation_p.T38M	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	38						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CAGCAGGACACGCCCGGAAGC	0.577													T	123810032	T	T	123810032	3	4	1	1	0	0	0	0	1	0	0	0	15499	536	19	1	119	1	TACC2	10	123810032	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08		123810032	11724715	33	33											
JAKMIP3	282973	broad.mit.edu	37	chr10	133967449	133967449	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagcagaagggctacctggaCgaggagctggactaccggaa	15	9	0	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr10:133967449C>T	uc001lkx.3	+	18	2169	c.2169C>T	c.(2167-2169)GAC>GAT	p.D723D	JAKMIP3_uc009yba.1_Silent_p.D160D	NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GCTACCTGGACGAGGAGCTGG	0.632													T	133967449	T	T	133967449	2	4	1	1	0	0	0	0	0	0	0	1	7942	535	19	1		1	JAKMIP3	10	133967449	Silent	SNP	C	TCGA-02-0003-01A-01D-1490-08	10157417	133967449	1567298	34	34											
NAALAD2	10003	broad.mit.edu	37	chr11	89868837	89868837	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaaacatcaaatcatttcttCggtaagtttattttacgtat	4	6	3	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr11:89868837C>T	uc001pdf.3	+	2	302	c.193C>T	c.(193-195)CGT>TGT	p.R65C	NAALAD2_uc009yvx.2_Missense_Mutation_p.R65C|NAALAD2_uc009yvy.2_Missense_Mutation_p.R65C|NAALAD2_uc001pdd.2_Missense_Mutation_p.R65C|NAALAD2_uc001pde.2_Missense_Mutation_p.R65C	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	65	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				ATCATTTCTTCGGTAAGTTTA	0.348													T	89868837	T	T	89868837	3	4	1	1	0	0	0	0	1	0	0	0	10128	898	31	2	199	2	NAALAD2	11	89868837	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08		89868837	45137679	35	35											
FAT3	120114	broad.mit.edu	37	chr11	92570936	92570936	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgtgaatgacaacagcccGgtgtttacacctgccaacta	9	11	0	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr11:92570936G>A	uc001pdj.3	+	16	10349	c.10332G>A	c.(10330-10332)CCG>CCA	p.P3444P	FAT3_uc001pdi.3_5'Flank	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3444	Extracellular (Potential).|Cadherin 31.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACAACAGCCCGGTGTTTACAC	0.468										TCGA Ovarian(4;0.039)			A	92570936	A	A	92570936	2	1	1	1	0	0	0	0	0	0	0	1	5691	1103	39	2		2	FAT3	11	92570936	Silent	SNP	G	TCGA-02-0003-01A-01D-1490-08	2702099	92570936	42435580	36	36											
PANX3	116337	broad.mit.edu	37	chr11	124489539	124489539	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacctcacacggctatgtcGgtgggacaaacgacttttat	9	11	1	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr11:124489539G>A	uc001qah.2	+	4	887	c.887G>A	c.(886-888)CGG>CAG	p.R296Q		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	296	Cytoplasmic (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CGGCTATGTCGGTGGGACAAA	0.438													A	124489539	A	A	124489539	3	1	1	1	0	0	0	0	1	0	0	0	11422	1116	39	2	901	2	PANX3	11	124489539	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	31918603	124489539	10516977	37	37											
SLC2A14	144195	broad.mit.edu	37	chr12	7980269	7980269	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcctgggtgccccacaacCgctggaggactggtgaaaag	13	12	0	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr12:7980269C>T	uc001qtk.2	-	12	1548	c.755G>A	c.(754-756)CGG>CAG	p.R252Q	SLC2A14_uc001qtl.2_Missense_Mutation_p.R229Q|SLC2A14_uc001qtm.2_Missense_Mutation_p.R229Q|SLC2A14_uc010sgg.1_Missense_Mutation_p.R143Q|SLC2A14_uc001qtn.2_Missense_Mutation_p.R252Q|SLC2A14_uc001qto.2_Intron|SLC2A14_uc010sgh.1_Missense_Mutation_p.R267Q	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	252	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		GCCCCACAACCGCTGGAGGAC	0.502													T	7980269	T	T	7980269	3	4	1	1	0	0	0	0	1	0	0	0	14543	652	23	2	827	2	SLC2A14	12	7980269	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08		7980269	125871626	38	38											
SLC2A3	6515	broad.mit.edu	37	chr12	8082458	8082458	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcctgggtgccccacaacCgctggaggactggtgaaaag	13	12	0	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr12:8082458C>T	uc001qtr.2	-	6	945	c.683G>A	c.(682-684)CGG>CAG	p.R228Q	SLC2A3_uc001qts.2_3'UTR	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	228	Cytoplasmic (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		GCCCCACAACCGCTGGAGGAC	0.493													T	8082458	T	T	8082458	3	4	1	1	0	0	0	0	1	0	0	0	14545	652	23	2	827	2	SLC2A3	12	8082458	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08	102189	8082458	125769437	39	39											
MTERFD3	80298	broad.mit.edu	37	chr12	107371855	107371855	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaataaatgggttttggcttAacaattttagtagccaaact	7	5	0	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr12:107371855A>G	uc001tme.1	-	2	2457	c.638T>C	c.(637-639)TTA>TCA	p.L213S	MTERFD3_uc001tmf.1_Missense_Mutation_p.L213S|MTERFD3_uc001tmg.1_Missense_Mutation_p.L213S|MTERFD3_uc001tmh.1_Missense_Mutation_p.L213S	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						GTTTTGGCTTAACAATTTTAG	0.383													G	107371855	G	G	107371855	3	3	1	1	0	0	0	0	1	0	0	0	9921	372	13	4	523	4	MTERFD3	12	107371855	Missense_Mutation	SNP	A	TCGA-02-0003-01A-01D-1490-08	99289397	107371855	26480040	40	40											
BTBD11	121551	broad.mit.edu	37	chr12	108012011	108012011	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccctggaggagattctggccGaggggactgacctggcggag	18	10	1	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr12:108012011G>A	uc001tmk.1	+	10	2829	c.2308G>A	c.(2308-2310)GAG>AAG	p.E770K	BTBD11_uc009zut.1_Intron|BTBD11_uc001tmj.2_Missense_Mutation_p.E770K|BTBD11_uc001tml.1_Missense_Mutation_p.E307K	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	770						integral to membrane	DNA binding			skin(2)|ovary(1)	3						GATTCTGGCCGAGGGGACTGA	0.607													A	108012011	A	A	108012011	3	1	1	1	0	0	0	0	1	0	0	0	1539	1059	37	2	2451	2	BTBD11	12	108012011	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	640156	108012011	25839884	41	41											
MYH6	4624	broad.mit.edu	37	chr14	23858709	23858709	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctccttttcctctagctgccGggccaactctcctggaggtg	10	15	2	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr14:23858709G>T	uc001wjv.2	-	28	3938	c.3871C>A	c.(3871-3873)CGG>AGG	p.R1291R	uc010tnn.1_5'Flank|MIR208A_hsa-mir-208a|MI0000251_5'Flank	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1291	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCTAGCTGCCGGGCCAACTCT	0.582													T	23858709	T	T	23858709	2	4	1	1	0	0	0	0	0	0	0	1	10038	1115	39	5		5	MYH6	14	23858709	Silent	SNP	G	TCGA-02-0003-01A-01D-1490-08		23858709	83490831	42	42											
AKAP6	9472	broad.mit.edu	37	chr14	33290999	33290999	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aactaagagtctcagtaaagActcttcattttcatctacca	4	10	5	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr14:33290999A>G	uc001wrq.2	+	13	4150	c.3980A>G	c.(3979-3981)GAC>GGC	p.D1327G		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1327					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTCAGTAAAGACTCTTCATTT	0.418													G	33290999	G	G	33290999	3	3	1	1	0	0	0	0	1	0	0	0	455	275	10	4	4026	4	AKAP6	14	33290999	Missense_Mutation	SNP	A	TCGA-02-0003-01A-01D-1490-08	9432290	33290999	74058541	43	43											
EML1	2009	broad.mit.edu	37	chr14	100363606	100363606	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaactgcagaggcattacGctggccacaacgatgacgtg	12	11	0	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr14:100363606G>A	uc001ygs.2	+	7	871	c.802G>A	c.(802-804)GCT>ACT	p.A268T	EML1_uc010avt.1_Missense_Mutation_p.A255T|EML1_uc010tww.1_Missense_Mutation_p.A256T|EML1_uc001ygq.2_Missense_Mutation_p.A287T|EML1_uc001ygr.2_Missense_Mutation_p.A287T	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	268						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GAGGCATTACGCTGGCCACAA	0.383													A	100363606	A	A	100363606	3	1	1	1	0	0	0	0	1	0	0	0	5096	1087	38	1	889	1	EML1	14	100363606	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	67072607	100363606	6985934	44	44											
WDR72	256764	broad.mit.edu	37	chr15	53998200	53998200	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	attcttcctgagacttctccAgagaaaagtaccttgtaaaa	6	9	2	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr15:53998200A>T	uc002acj.2	-	10	1068	c.1026T>A	c.(1024-1026)TCT>TCA	p.S342S	WDR72_uc010bfi.1_Silent_p.S342S	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	342	WD 4.									lung(1)|skin(1)	2				all cancers(107;0.0511)		AGACTTCTCCAGAGAAAAGTA	0.403													T	53998200	T	T	53998200	2	4	1	1	0	0	0	0	0	0	0	1	17319	175	7	5		5	WDR72	15	53998200	Silent	SNP	A	TCGA-02-0003-01A-01D-1490-08		53998200	48533192	45	45											
GNPTG	84572	broad.mit.edu	37	chr16	1412529	1412529	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggccgatgagctgatcacCccccaggtaagcgtgcgctc	12	15	1	2	rs146171435	byFrequency	TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr16:1412529C>T	uc002clm.2	+	8	638	c.603C>T	c.(601-603)ACC>ACT	p.T201T		NM_032520	NP_115909	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase, gamma	201						extracellular region|Golgi apparatus	protein binding			central_nervous_system(1)	1		Hepatocellular(780;0.0893)				AGCTGATCACCCCCCAGGTAA	0.667													T	1412529	T	T	1412529	2	4	1	1	0	0	0	0	0	0	0	1	6546	610	22	3		3	GNPTG	16	1412529	Silent	SNP	C	TCGA-02-0003-01A-01D-1490-08		1412529	88942224	46	46											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1815961	1815961	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggccgtccctctccccagCggccagcgacagcgactacc	11	20	1	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr16:1815961C>T	uc002cmk.2	+	21	2564	c.2444C>T	c.(2443-2445)GCG>GTG	p.A815V	MAPK8IP3_uc002cml.2_Missense_Mutation_p.A809V|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.A816V	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	815					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CTCTCCCCAGCGGCCAGCGAC	0.687													T	1815961	T	T	1815961	3	4	1	1	0	0	0	0	1	0	0	0	9286	782	27	1	2542	1	MAPK8IP3	16	1815961	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08	403432	1815961	88538792	47	47											
SPATA22	84690	broad.mit.edu	37	chr17	3366028	3366028	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccactgttttcattacaggaGccaactctggattcacagct	7	12	3	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr17:3366028G>A	uc002fvm.2	-	4	443	c.206C>T	c.(205-207)GCT>GTT	p.A69V	SPATA22_uc010vrg.1_Missense_Mutation_p.A53V|SPATA22_uc010vrf.1_Missense_Mutation_p.A69V|SPATA22_uc002fvn.2_Missense_Mutation_p.A69V|SPATA22_uc002fvo.2_Missense_Mutation_p.A69V|SPATA22_uc002fvp.2_Missense_Mutation_p.A69V|SPATA22_uc010ckf.2_Missense_Mutation_p.A26V	NM_032598	NP_115987	Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	69											0						CATTACAGGAGCCAACTCTGG	0.348													A	3366028	A	A	3366028	3	1	1	1	0	0	0	0	1	0	0	0	15007	971	34	3	909	3	SPATA22	17	3366028	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08		3366028	77829182	48	48											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	9	16	3	0	rs28934574		TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577094	A	A	7577094	3	1	1	1	0	0	0	0	1	0	0	0	16378	1115	39	2	442	2	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	4211066	7577094	73618116	49	49											
TP53	7157	broad.mit.edu	37	chr17	7578396	7578396	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctatctgagcagcgctcatgGtgggggcagcgcctcacaac	13	13	3	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr17:7578396G>T	uc002gim.2	-	5	728	c.534C>A	c.(532-534)CAC>CAA	p.H178Q	TP53_uc002gig.1_Missense_Mutation_p.H178Q|TP53_uc002gih.2_Missense_Mutation_p.H178Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H46Q|TP53_uc010cng.1_Missense_Mutation_p.H46Q|TP53_uc002gii.1_Missense_Mutation_p.H46Q|TP53_uc010cnh.1_Missense_Mutation_p.H178Q|TP53_uc010cni.1_Missense_Mutation_p.H178Q|TP53_uc002gij.2_Missense_Mutation_p.H178Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H85Q|TP53_uc002gio.2_Missense_Mutation_p.H46Q|TP53_uc010vug.1_Missense_Mutation_p.H139Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	178	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> L (in a sporadic cancer; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> HPHP (in a Burkitt lymphoma).|H -> D (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H178fs*69(13)|p.P177_C182delPHHERC(8)|p.H179Y(8)|p.H178Y(8)|p.0?(7)|p.H178P(6)|p.H178fs*3(5)|p.H178Q(5)|p.H178D(4)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.H178N(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.H178H(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.R175_H178>X(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.H178_H179>QY(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.H178del(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.H178L(1)|p.R174fs*3(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGCGCTCATGGTGGGGGCAGC	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578396	T	T	7578396	3	4	1	1	0	0	0	0	1	0	0	0	16378	1252	44	5	764	5	TP53	17	7578396	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	1302	7578396	73616814	50	50											
HOXB1	3211	broad.mit.edu	37	chr17	46607715	46607715	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttgggtgggtttctcttaacCttcatccagtcgaaggtccg	11	10	2	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr17:46607715C>A	uc002ink.1	-	1	558	c.552G>T	c.(550-552)AAG>AAT	p.K184N		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	184	Antp-type hexapeptide.					nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTCTCTTAACCTTCATCCAGT	0.592													A	46607715	A	A	46607715	3	1	1	1	0	0	0	0	1	0	0	0	7299	680	24	5	361	5	HOXB1	17	46607715	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08	39029319	46607715	34587495	51	51											
FUT5	2527	broad.mit.edu	37	chr19	5867712	5867712	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcggcgccacagccactgtgGcttggctgggcccaggggat	17	13	0	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr19:5867712G>T	uc002mdo.3	-	2	113	c.25C>A	c.(25-27)CCA>ACA	p.P9T	FUT5_uc010duo.2_Missense_Mutation_p.P9T	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	9	Cytoplasmic (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						AGCCACTGTGGCTTGGCTGGG	0.607													T	5867712	T	T	5867712	3	4	1	1	0	0	0	0	1	0	0	0	6107	1203	42	5	1103	5	FUT5	19	5867712	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08		5867712	53261271	52	52											
ILF3	3609	broad.mit.edu	37	chr19	10789305	10789305	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atagaaacgctatcagtcaaCgaccccccggacgttctgga	9	13	3	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr19:10789305C>T	uc002mpn.2	+	6	893	c.576C>T	c.(574-576)AAC>AAT	p.N192N	ILF3_uc002mpm.2_Silent_p.N192N|ILF3_uc002mpl.2_Silent_p.N192N|ILF3_uc002mpk.2_Silent_p.N192N|ILF3_uc010xli.1_Intron|ILF3_uc002mpo.2_Silent_p.N192N|ILF3_uc002mpp.2_Silent_p.N13N	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	192	DZF.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			TATCAGTCAACGACCCCCCGG	0.502													T	10789305	T	T	10789305	2	4	1	1	0	0	0	0	0	0	0	1	7712	535	19	1		1	ILF3	19	10789305	Silent	SNP	C	TCGA-02-0003-01A-01D-1490-08	4921593	10789305	48339678	53	53											
PODNL1	79883	broad.mit.edu	37	chr19	14046616	14046616	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccgcgacacggagggaccGgggcagaaactgaggggcca	17	11	0	2	rs142083249		TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr19:14046616G>A	uc002mxr.2	-	5	707	c.433C>T	c.(433-435)CGG>TGG	p.R145W	PODNL1_uc010xni.1_Missense_Mutation_p.R63W|PODNL1_uc010xnj.1_Missense_Mutation_p.R143W|PODNL1_uc002mxs.2_Intron	NM_024825	NP_079101	Q6PEZ8	PONL1_HUMAN	podocan-like 1 isoform 1	145	LRR 3.|Leu-rich.					proteinaceous extracellular matrix				central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(19;5.26e-23)			CGGAGGGACCGGGGCAGAAAC	0.657													A	14046616	A	A	14046616	3	1	1	1	0	0	0	0	1	0	0	0	12179	1115	39	2	1121	2	PODNL1	19	14046616	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	3257311	14046616	45082367	54	54											
NLRP5	126206	broad.mit.edu	37	chr19	56538455	56538455	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgcacggtggttctgcacGgaaagtcaggaattgggaaa	14	8	2	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr19:56538455G>A	uc002qmj.2	+	7	856	c.856G>A	c.(856-858)GGA>AGA	p.G286R	NLRP5_uc002qmi.2_Missense_Mutation_p.G267R	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	286	NACHT.|ATP (Potential).					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GGTTCTGCACGGAAAGTCAGG	0.547													A	56538455	A	A	56538455	3	1	1	1	0	0	0	0	1	0	0	0	10480	1117	39	2	882	2	NLRP5	19	56538455	Missense_Mutation	SNP	G	TCGA-02-0003-01A-01D-1490-08	42491839	56538455	2590528	55	55											
ZNF583	147949	broad.mit.edu	37	chr19	56934399	56934399	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgagagaagactgtcaaagTgaggactggtataagaacca	12	5	1	5			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr19:56934399T>G	uc010ygl.1	+	5	537	c.372T>G	c.(370-372)AGT>AGG	p.S124R	ZNF583_uc002qnc.2_Missense_Mutation_p.S124R|ZNF583_uc010ygm.1_Missense_Mutation_p.S124R	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		ACTGTCAAAGTGAGGACTGGT	0.383													G	56934399	G	G	56934399	3	3	1	1	0	0	0	0	1	0	0	0	18012	1693	59	5	386	5	ZNF583	19	56934399	Missense_Mutation	SNP	T	TCGA-02-0003-01A-01D-1490-08	395944	56934399	2194584	56	56											
TSHZ2	128553	broad.mit.edu	37	chr20	51872260	51872260	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcagccagcgtgtccaggCgctacctgtttgagaacagc	13	12	1	1			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr20:51872260C>T	uc002xwo.2	+	2	3219	c.2263C>T	c.(2263-2265)CGC>TGC	p.R755C		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	755					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CGTGTCCAGGCGCTACCTGTT	0.512													T	51872260	T	T	51872260	3	4	1	1	0	0	0	0	1	0	0	0	16621	768	27	1	2269	1	TSHZ2	20	51872260	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08		51872260	11153260	57	57											
FAM83F	113828	broad.mit.edu	37	chr22	40417570	40417570	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcaacagcgggaggcgggCggcaacccggaggggcagga	21	11	0	0			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr22:40417570C>T	uc003ayk.1	+	4	1150	c.1056C>T	c.(1054-1056)GGC>GGT	p.G352G		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	352										breast(1)	1						GGGAGGCGGGCGGCAACCCGG	0.687													T	40417570	T	T	40417570	2	4	1	1	0	0	0	0	0	0	0	1	5638	755	27	1		1	FAM83F	22	40417570	Silent	SNP	C	TCGA-02-0003-01A-01D-1490-08		40417570	10886996	58	58											
PKDREJ	10343	broad.mit.edu	37	chr22	46656782	46656782	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttttaagaatattagacaaaCtcattagtattccagtactc	4	7	1	2			TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chr22:46656782C>A	uc003bhh.2	-	1	2438	c.2438G>T	c.(2437-2439)AGT>ATT	p.S813I		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	813	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATTAGACAAACTCATTAGTAT	0.348													A	46656782	A	A	46656782	3	1	1	1	0	0	0	0	1	0	0	0	11970	565	20	5	4327	5	PKDREJ	22	46656782	Missense_Mutation	SNP	C	TCGA-02-0003-01A-01D-1490-08	6239212	46656782	4647784	59	59											
KLHL13	90293	broad.mit.edu	37	chrX	117035907	117035907	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggattgtaacattctactgTggctgttaaaaaaaaaaaga	8	4	1	1	rs148032932		TCGA-02-0003-01A-01D-1490-08	TCGA-02-0003-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	458f13e0-34f3-4a92-b3b3-9a3c2ee3ef23	0b63ce82-23d2-48d4-be99-3959917d94ea	g.chrX:117035907T>C	uc004eql.2	-	6	1431	c.1369A>G	c.(1369-1371)ACA>GCA	p.T457A	KLHL13_uc004eqk.2_Missense_Mutation_p.T406A|KLHL13_uc011mtn.1_Missense_Mutation_p.T297A|KLHL13_uc011mto.1_Missense_Mutation_p.T451A|KLHL13_uc011mtp.1_Missense_Mutation_p.T459A|KLHL13_uc004eqm.2_Missense_Mutation_p.T406A|KLHL13_uc011mtq.1_Missense_Mutation_p.T441A	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	457	Kelch 3.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						CATTCTACTGTGGCTGTTAAA	0.323													C	117035907	C	C	117035907	3	2	1	1	0	0	0	0	1	0	0	0	8369	1696	59	4	606	4	KLHL13	23	117035907	Missense_Mutation	SNP	T	TCGA-02-0003-01A-01D-1490-08		117035907	38234653	60	60											
CYR61	3491	broad.mit.edu	37	chr1	86047880	86047881	+	In_Frame_Ins	INS	-	TGG	TGG													cggcctccttggcaaggagcINStgggattcgatgcctccgag							TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr1:86047880_86047881insTGG	uc001dle.2	+	3	771_772	c.547_548insTGG	c.(547-549)CTG>CTGGTG	p.183_184insV	CYR61_uc001dlg.2_In_Frame_Ins_p.12_13insV|CYR61_uc009wcp.1_5'Flank	NM_001554	NP_001545	O00622	CYR61_HUMAN	cysteine-rich, angiogenic inducer, 61 precursor	183_184					cell proliferation|chemotaxis|positive regulation of BMP signaling pathway|positive regulation of cell migration|positive regulation of osteoblast differentiation|positive regulation of osteoblast proliferation|positive regulation of protein kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell growth|regulation of ERK1 and ERK2 cascade|wound healing, spreading of cells	extracellular region	heparin binding|insulin-like growth factor binding			central_nervous_system(1)	1				all cancers(265;0.0216)|Epithelial(280;0.0441)		TGGCAAGGAGCTGGGATTCGAT	0.559											OREG0013583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	TGG	86047881	TGG	TGG	86047880	7	5	2	1	0	1	1	0	0	0	0	0	4199	796	28	0	557	0	CYR61	1	86047880	In_Frame_Ins	INS	-	TCGA-02-0033-01A-01D-1490-08		86047880	163202741	1	61											
NBPF9	400818	broad.mit.edu	37	chr1	144825409	144825409	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtcttgcaggactcactggGtagatggtattcgactcctt	11	9	2	1	rs558823		TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr1:144825409G>A	uc009wig.1	+	19	2211	c.2135G>A	c.(2134-2136)GGT>GAT	p.G712D	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.G637D|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.G513D|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Missense_Mutation_p.G372D	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	712	NBPF 5.					cytoplasm					0						GACTCACTGGGTAGATGGTAT	0.493													A	144825409	A	A	144825409	3	1	2	1	0	0	0	0	1	0	0	0	10199	1261	44	3	2195	3	NBPF9	1	144825409	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	58777529	144825409	104425212	2	62											
PIGR	5284	broad.mit.edu	37	chr1	207110686	207110686	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtcggcacagaaatttggCcacgtttgccacctcagggc	11	13	1	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr1:207110686C>T	uc001hez.2	-	4	983	c.799G>A	c.(799-801)GCC>ACC	p.A267T	PIGR_uc009xbz.2_Missense_Mutation_p.A267T	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	267	Ig-like V-type 3.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						AGAAATTTGGCCACGTTTGCC	0.592													T	207110686	T	T	207110686	3	4	2	1	0	0	0	0	1	0	0	0	11897	739	26	3	1527	3	PIGR	1	207110686	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08	62285277	207110686	42139935	3	63											
LIN9	286826	broad.mit.edu	37	chr1	226426780	226426780	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgctgaaattcaatgctgatGggcatggaatatgatttctg	11	6	2	3			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr1:226426780G>A	uc001hqa.2	-	12	1495	c.1185C>T	c.(1183-1185)CCC>CCT	p.P395P	LIN9_uc001hqb.2_Silent_p.P360P|LIN9_uc001hqc.2_Silent_p.P327P|LIN9_uc009xel.1_Silent_p.P360P	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	379	Potential.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		CAATGCTGATGGGCATGGAAT	0.343													A	226426780	A	A	226426780	2	1	2	1	0	0	0	0	0	0	0	1	8813	1335	47	3		3	LIN9	1	226426780	Silent	SNP	G	TCGA-02-0033-01A-01D-1490-08	19316094	226426780	22823841	4	64											
FAM126B	285172	broad.mit.edu	37	chr2	201857004	201857004	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagttaagataataacttacCaatagtggttgagaaaaaag	9	3	0	2			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr2:201857004C>T	uc002uws.3	-	10	1019	c.831G>A	c.(829-831)TTG>TTA	p.L277L	FAM126B_uc002uwu.2_Silent_p.L195L|FAM126B_uc002uwv.2_Silent_p.L277L	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	277						intracellular				ovary(1)	1						AATAACTTACCAATAGTGGTT	0.333													T	201857004	T	T	201857004	2	4	2	1	0	0	0	0	0	0	0	1	5430	608	21	3		3	FAM126B	2	201857004	Silent	SNP	C	TCGA-02-0033-01A-01D-1490-08		201857004	41342369	5	65											
IRS1	3667	broad.mit.edu	37	chr2	227662172	227662172	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gactggagccatactcatccGaggagatgaaaccgccatcg	11	12	1	2			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr2:227662172G>A	uc002voh.3	-	1	1335	c.1283C>T	c.(1282-1284)TCG>TTG	p.S428L		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	428	Ser-rich.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity	p.S428L(1)		lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		ATACTCATCCGAGGAGATGAA	0.617											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	227662172	A	A	227662172	3	1	2	1	0	0	0	0	1	0	0	0	7840	1059	37	2	2449	2	IRS1	2	227662172	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	25805168	227662172	15537201	6	66											
FLNB	2317	broad.mit.edu	37	chr3	58140654	58140654	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcttatattgcccaagagccTggtatgtattcagggttcac	9	9	3	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr3:58140654T>C	uc003djj.2	+	40	6936	c.6771T>C	c.(6769-6771)CCT>CCC	p.P2257P	FLNB_uc010hne.2_Silent_p.P2288P|FLNB_uc003djk.2_Silent_p.P2246P|FLNB_uc010hnf.2_Silent_p.P2233P|FLNB_uc003djl.2_Silent_p.P2077P|FLNB_uc003djm.2_Silent_p.P2064P	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2257	Interaction with INPPL1.|Filamin 21.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCCAAGAGCCTGGTATGTATT	0.353													C	58140654	C	C	58140654	2	2	2	1	0	0	0	0	0	0	0	1	5934	1594	55	4		4	FLNB	3	58140654	Silent	SNP	T	TCGA-02-0033-01A-01D-1490-08		58140654	139881776	7	67											
SLC9A10	285335	broad.mit.edu	37	chr3	111887770	111887770	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaggtgctctataagtttttCgtaacagacaatcttctaca	6	8	3	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr3:111887770C>T	uc003dyu.2	-	25	3413	c.3191G>A	c.(3190-3192)CGA>CAA	p.R1064Q	SLC9A10_uc011bhu.1_Missense_Mutation_p.R327Q|SLC9A10_uc010hqc.2_Missense_Mutation_p.R1016Q	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	1064					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						ATAAGTTTTTCGTAACAGACA	0.323													T	111887770	T	T	111887770	3	4	2	1	0	0	0	0	1	0	0	0	14710	884	31	2	362	2	SLC9A10	3	111887770	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08	53747116	111887770	86134660	8	68											
HLTF	6596	broad.mit.edu	37	chr3	148804115	148804115	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccccttcacctcttgaacatCcaggacatggcgctgagtgg	10	14	2	2			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr3:148804115C>T	uc003ewq.1	-	1	227	c.9G>A	c.(7-9)TGG>TGA	p.W3*	HLTF_uc003ewr.1_Nonsense_Mutation_p.W3*|HLTF_uc003ews.1_Nonsense_Mutation_p.W3*|HLTF_uc010hve.1_Nonsense_Mutation_p.W3*	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	3					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TCTTGAACATCCAGGACATGG	0.652													T	148804115	T	T	148804115	4	4	2	1	0	0	0	0	0	1	0	0	7215	856	30	3	3120	3	HLTF	3	148804115	Nonsense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08	36916345	148804115	49218315	9	69											
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctacacgagatcctctctctGaaatcactgagcaggagaaa	8	11	3	4	rs121913273		TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178936082	A	A	178936082	3	1	2	1	0	0	0	0	1	0	0	0	11913	1291	45	3	1658	3	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	30131967	178936082	19086348	10	70											
LARP1B	55132	broad.mit.edu	37	chr4	129003366	129003366	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacttagatgttgtaagatcAgagagtcaagaaagacctgg	11	6	2	5			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr4:129003366A>G	uc003iga.2	+	5	395	c.264A>G	c.(262-264)TCA>TCG	p.S88S	LARP1B_uc003ifw.1_Intron|LARP1B_uc003ifx.2_Silent_p.S88S|LARP1B_uc003ify.2_Silent_p.S88S|LARP1B_uc003ifz.1_Silent_p.S88S	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	88							RNA binding				0						TTGTAAGATCAGAGAGTCAAG	0.373													G	129003366	G	G	129003366	2	3	2	1	0	0	0	0	0	0	0	1	8629	175	7	4		4	LARP1B	4	129003366	Silent	SNP	A	TCGA-02-0033-01A-01D-1490-08		129003366	62150910	11	71											
PCDHA1	56147	broad.mit.edu	37	chr5	140167909	140167909	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcggccaggcgccaaaggcGtcttcgcgggcgtcggtggg	19	12	1	0			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr5:140167909G>A	uc003lhb.2	+	1	2034	c.2034G>A	c.(2032-2034)GCG>GCA	p.A678A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Silent_p.A678A	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	678	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCAAAGGCGTCTTCGCGGG	0.662													A	140167909	A	A	140167909	2	1	2	1	0	0	0	0	0	0	0	1	11519	1132	40	1		1	PCDHA1	5	140167909	Silent	SNP	G	TCGA-02-0033-01A-01D-1490-08		140167909	40747351	12	72											
HRH2	3274	broad.mit.edu	37	chr5	175110363	175110363	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtggtcgtctgtctggccGtgggcttgaaccgccggctc	15	12	2	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr5:175110363G>A	uc003mdd.2	+	1	1900	c.127G>A	c.(127-129)GTG>ATG	p.V43M	HRH2_uc003mdc.3_Missense_Mutation_p.V43M	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	43	Helical; Name=1; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CTGTCTGGCCGTGGGCTTGAA	0.587													A	175110363	A	A	175110363	3	1	2	1	0	0	0	0	1	0	0	0	7356	1145	40	1	129	1	HRH2	5	175110363	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	34942454	175110363	5804897	13	73											
SEMA3C	10512	broad.mit.edu	37	chr7	80546078	80546078	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taaatactccaaccaacacgCaaattgtccggaatgccatt	5	12	0	0			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr7:80546078C>A	uc003uhj.2	-	2	582	c.20G>T	c.(19-21)TGC>TTC	p.C7F	SEMA3C_uc011kgw.1_Missense_Mutation_p.C25F|SEMA3C_uc011kgx.1_5'UTR	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	7					immune response|response to drug	membrane	receptor activity			ovary(1)	1						AACCAACACGCAAATTGTCCG	0.353													A	80546078	A	A	80546078	3	1	2	1	0	0	0	0	1	0	0	0	14026	710	25	5	2303	5	SEMA3C	7	80546078	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08		80546078	78592585	14	74											
PDIA4	9601	broad.mit.edu	37	chr7	148703125	148703125	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagcacgaagtccttgatGgccgagtcctgggtggagcc	14	11	1	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr7:148703125G>A	uc003wff.2	-	8	1434	c.1152C>T	c.(1150-1152)GCC>GCT	p.A384A		NM_004911	NP_004902	P13667	PDIA4_HUMAN	protein disulfide isomerase A4 precursor	384					cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			lung(5)|ovary(1)	6	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			AGTCCTTGATGGCCGAGTCCT	0.592											OREG0018420	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	148703125	A	A	148703125	2	1	2	1	0	0	0	0	0	0	0	1	11670	1335	47	3		3	PDIA4	7	148703125	Silent	SNP	G	TCGA-02-0033-01A-01D-1490-08	68157047	148703125	10435538	15	75											
ZDHHC2	51201	broad.mit.edu	37	chr8	17072848	17072848	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcagcataaacccaggaaaAtgcaaagctggtaagggtgt	12	7	0	0			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr8:17072848A>G	uc003wxe.2	+	11	1450	c.1053A>G	c.(1051-1053)AAA>AAG	p.K351K		NM_016353	NP_057437	Q9UIJ5	ZDHC2_HUMAN	zinc finger, DHHC-type containing 2	351						integral to membrane	acyltransferase activity|zinc ion binding				0				Colorectal(111;0.0697)|COAD - Colon adenocarcinoma(73;0.244)		ACCCAGGAAAATGCAAAGCTG	0.403													G	17072848	G	G	17072848	2	3	2	1	0	0	0	0	0	0	0	1	17607	98	4	4		4	ZDHHC2	8	17072848	Silent	SNP	A	TCGA-02-0033-01A-01D-1490-08		17072848	129291174	16	76											
FBXO16	157574	broad.mit.edu	37	chr8	28321322	28321322	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttcttcttctttgagagtctGtccatttgtcaaactggaaa	7	8	5	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr8:28321322G>T	uc003xgu.2	-	4	247	c.149C>A	c.(148-150)ACA>AAA	p.T50K	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.T37K|FBXO16_uc003xgw.2_Missense_Mutation_p.T37K	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	50										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		TTGAGAGTCTGTCCATTTGTC	0.428													T	28321322	T	T	28321322	3	4	2	1	0	0	0	0	1	0	0	0	5729	1377	48	5	753	5	FBXO16	8	28321322	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	11248474	28321322	118042700	17	77											
KIAA0020	9933	broad.mit.edu	37	chr9	2829854	2829854	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatggctttgtcattgtatgCgtactccacgatggctgatg	11	8	1	1	rs62534389		TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr9:2829854C>T	uc003zhp.1	-	8	868	c.772G>A	c.(772-774)GCA>ACA	p.A258T	KIAA0020_uc010mhc.1_Missense_Mutation_p.A257T|KIAA0020_uc003zhq.1_Missense_Mutation_p.A257T	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	258	Pumilio 3.|PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		TCATTGTATGCGTACTCCACG	0.458													T	2829854	T	T	2829854	3	4	2	1	0	0	0	0	1	0	0	0	8152	768	27	1	1218	1	KIAA0020	9	2829854	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08		2829854	138383577	18	78											
C9orf25	203259	broad.mit.edu	37	chr9	34401054	34401054	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatgaggtctaggtcctcgtCgtcggggatctcatctaacc	12	11	3	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr9:34401054C>T	uc011lok.1	-	6	773	c.466G>A	c.(466-468)GAC>AAC	p.D156N	C9orf25_uc003zuj.2_Missense_Mutation_p.D139N|C9orf25_uc003zuk.2_Missense_Mutation_p.D128N|C9orf25_uc011lol.1_Missense_Mutation_p.D144N|C9orf25_uc003zul.2_Missense_Mutation_p.D127N	NM_147202	NP_671735	Q8IW50	CI025_HUMAN	hypothetical protein LOC203259	156											0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.0858)		AGGTCCTCGTCGTCGGGGATC	0.617													T	34401054	T	T	34401054	3	4	2	1	0	0	0	0	1	0	0	0	2476	884	31	2	95	2	C9orf25	9	34401054	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08	31571200	34401054	106812377	19	79											
FAM75C1	441452	broad.mit.edu	37	chr9	90537820	90537820	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacccgtcagaatgaaggcGtccagctactgccatcaaag	9	13	2	2			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr9:90537820G>A	uc010mqi.2	+	4	3027	c.2998G>A	c.(2998-3000)GTC>ATC	p.V1000I	FAM75C1_uc004apq.3_Missense_Mutation_p.V983I	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GAATGAAGGCGTCCAGCTACT	0.408													A	90537820	A	A	90537820	3	1	2	1	0	0	0	0	1	0	0	0	5623	1145	40	1	3012	1	FAM75C1	9	90537820	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	56136766	90537820	50675611	20	80											
EGFL7	51162	broad.mit.edu	37	chr9	139564727	139564727	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcacagcctgtctgcagaCggtacactctgtgtgcccaa	12	13	2	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr9:139564727C>T	uc004cid.2	+	7	1427	c.516C>T	c.(514-516)GAC>GAT	p.D172D	EGFL7_uc004cif.2_Silent_p.D172D|EGFL7_uc004cig.2_RNA|EGFL7_uc010nbp.2_Silent_p.D172D|EGFL7_uc004cie.2_Silent_p.D172D|EGFL7_uc004cih.2_Silent_p.D172D|MIR126_hsa-mir-126|MI0000471_5'Flank	NM_201446	NP_958854	Q9UHF1	EGFL7_HUMAN	EGF-like-domain, multiple 7	172	EGF-like 2; calcium-binding (Potential).				angiogenesis|vasculogenesis		calcium ion binding			ovary(1)	1	all_cancers(76;0.109)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		TGTCTGCAGACGGTACACTCT	0.677													T	139564727	T	T	139564727	2	4	2	1	0	0	0	0	0	0	0	1	4964	535	19	1		1	EGFL7	9	139564727	Silent	SNP	C	TCGA-02-0033-01A-01D-1490-08	49026907	139564727	1648704	21	81											
ADARB2	105	broad.mit.edu	37	chr10	1405297	1405297	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgaacagctcctgcagtgCggcctgcgcggcctgacccc	13	17	0	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr10:1405297C>T	uc009xhq.2	-	3	1377	c.1003G>A	c.(1003-1005)GCA>ACA	p.A335T		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	335	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		TCCTGCAGTGCGGCCTGCGCG	0.746													T	1405297	T	T	1405297	3	4	2	1	0	0	0	0	1	0	0	0	283	768	27	1	1248	1	ADARB2	10	1405297	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08		1405297	134129450	22	82											
FGFR2	2263	broad.mit.edu	37	chr10	123298220	123298220	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cataatgaggctccagtgctGgtttcgtacctgaaaagatc	10	9	0	3			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr10:123298220G>T	uc010qtk.1	-	6	1281	c.634C>A	c.(634-636)CAG>AAG	p.Q212K	FGFR2_uc010qtg.1_Missense_Mutation_p.Q212K|FGFR2_uc010qth.1_Missense_Mutation_p.Q97K|FGFR2_uc010qti.1_Missense_Mutation_p.Q123K|FGFR2_uc010qtj.1_Missense_Mutation_p.Q212K|FGFR2_uc010qtl.1_Missense_Mutation_p.Q212K|FGFR2_uc010qtm.1_Missense_Mutation_p.Q97K|FGFR2_uc001lfl.3_Missense_Mutation_p.Q212K|FGFR2_uc001lfm.2_Missense_Mutation_p.Q123K|FGFR2_uc001lfn.3_RNA|FGFR2_uc010qtn.1_Missense_Mutation_p.Q231K|FGFR2_uc010qto.1_Missense_Mutation_p.Q116K|FGFR2_uc001lfo.1_Missense_Mutation_p.Q231K|FGFR2_uc010qtp.1_Missense_Mutation_p.Q231K|FGFR2_uc010qtq.1_Missense_Mutation_p.Q231K	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	212	Ig-like C2-type 2.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.Q212K(1)		endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CTCCAGTGCTGGTTTCGTACC	0.418		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				T	123298220	T	T	123298220	3	4	2	1	0	0	0	0	1	0	0	0	5866	1357	47	5	2139	5	FGFR2	10	123298220	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	121892923	123298220	12236527	23	83											
SLC22A9	114571	broad.mit.edu	37	chr11	63141216	63141216	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctcatttactgctcactaCgcttcttgtctgggattgct	7	12	4	0			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr11:63141216C>T	uc001nww.2	+	3	875	c.607C>T	c.(607-609)CGC>TGC	p.R203C	SLC22A9_uc001nwx.2_Intron	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	203	Extracellular (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						CTGCTCACTACGCTTCTTGTC	0.458													T	63141216	T	T	63141216	3	4	2	1	0	0	0	0	1	0	0	0	14461	536	19	1	617	1	SLC22A9	11	63141216	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08		63141216	71865300	24	84											
TSKU	25987	broad.mit.edu	37	chr11	76506917	76506917	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggggccgggctacacgacgtTggctggcctggatctcagcc	16	13	1	0			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr11:76506917T>G	uc001oxt.2	+	2	429	c.257T>G	c.(256-258)TTG>TGG	p.L86W		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	86	LRR 2.					extracellular region					0	Ovarian(111;0.112)					TACACGACGTTGGCTGGCCTG	0.632													G	76506917	G	G	76506917	3	3	2	1	0	0	0	0	1	0	0	0	16624	1821	63	5	259	5	TSKU	11	76506917	Missense_Mutation	SNP	T	TCGA-02-0033-01A-01D-1490-08	13365701	76506917	58499599	25	85											
GPR19	2842	broad.mit.edu	37	chr12	12814147	12814155	+	In_Frame_Del	DEL	ATTTGGTGG	-	-													atgagaacttagacaaaagtAtttggtggatttgagttaat					rs61733942		TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr12:12814147_12814155delATTTGGTGG	uc001rar.3	-	2	1421_1429	c.1228_1236delCCACCAAAT	c.(1228-1236)CCACCAAATdel	p.PPN410del	GPR19_uc001raq.2_In_Frame_Del_p.PPN410del	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	410_412	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		AGACAAAAGTATTTGGTGGATTTGAGTTA	0.34													-	12814155	-	-	12814147	7	5	2	1	0	1	0	1	0	0	0	0	6679	446	16	0	15	0	GPR19	12	12814147	In_Frame_Del	DEL	ATTTGGTGG	TCGA-02-0033-01A-01D-1490-08		12814147	121037748	26	86											
CDKN1B	1027	broad.mit.edu	37	chr12	12871093	12871093	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtgccggcgcaggagagccAggatgtcagcgggagccgcc	19	12	1	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr12:12871093A>G	uc001rat.2	+	1	792	c.320A>G	c.(319-321)CAG>CGG	p.Q107R		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	107					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		CAGGAGAGCCAGGATGTCAGC	0.642									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				G	12871093	G	G	12871093	3	3	2	1	0	0	0	0	1	0	0	0	3159	188	7	4	322	4	CDKN1B	12	12871093	Missense_Mutation	SNP	A	TCGA-02-0033-01A-01D-1490-08	56946	12871093	120980802	27	87											
ITGA7	3679	broad.mit.edu	37	chr12	56078847	56078847	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggacatgggaacctaggCggtgcctggccctggatgcc	16	12	0	0			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr12:56078847C>T	uc001shh.2	-	25	3641	c.3421G>A	c.(3421-3423)GCC>ACC	p.A1141T	ITGA7_uc001shg.2_Missense_Mutation_p.A1137T|ITGA7_uc010sps.1_Missense_Mutation_p.A1044T|ITGA7_uc001shf.2_3'UTR|ITGA7_uc009znw.2_Missense_Mutation_p.A384T|ITGA7_uc009znx.2_Missense_Mutation_p.A1018T	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	1181	Cytoplasmic (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						GGAACCTAGGCGGTGCCTGGC	0.697													T	56078847	T	T	56078847	3	4	2	1	0	0	0	0	1	0	0	0	7881	768	27	1	8	1	ITGA7	12	56078847	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08	43207754	56078847	77773048	28	88											
ANKRD52	283373	broad.mit.edu	37	chr12	56639298	56639298	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaggccaggtgaatgggcGtgcggcccttaaagtctcgg	16	10	1	2			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr12:56639298G>A	uc001skm.3	-	21	2357	c.2267C>T	c.(2266-2268)ACG>ATG	p.T756M		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	756	ANK 22.						protein binding			ovary(2)	2						GTGAATGGGCGTGCGGCCCTT	0.627													A	56639298	A	A	56639298	3	1	2	1	0	0	0	0	1	0	0	0	678	1145	40	1	995	1	ANKRD52	12	56639298	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	560451	56639298	77212597	29	89											
ACADS	35	broad.mit.edu	37	chr12	121176680	121176680	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccggctgctgacctggcgcGctgccatgctgaaggataac	13	14	0	2			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr12:121176680G>A	uc001tza.3	+	8	1109	c.991G>A	c.(991-993)GCT>ACT	p.A331T	ACADS_uc010szl.1_Missense_Mutation_p.A327T|ACADS_uc001tzb.3_Missense_Mutation_p.A212T	NM_000017	NP_000008	P16219	ACADS_HUMAN	short-chain acyl-CoA dehydrogenase precursor	331						mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(2)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	GACCTGGCGCGCTGCCATGCT	0.637													A	121176680	A	A	121176680	3	1	2	1	0	0	0	0	1	0	0	0	114	1087	38	1	1021	1	ACADS	12	121176680	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	64537382	121176680	12675215	30	90											
WDR66	144406	broad.mit.edu	37	chr12	122437781	122437781	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaagagctttgaggtgctcGgttataccaactccaaaggg	11	9	0	2			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr12:122437781G>A	uc009zxk.2	+	20	3308	c.3166G>A	c.(3166-3168)GGT>AGT	p.G1056S		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	1056							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		TGAGGTGCTCGGTTATACCAA	0.448													A	122437781	A	A	122437781	3	1	2	1	0	0	0	0	1	0	0	0	17314	1116	39	2	3299	2	WDR66	12	122437781	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	1261101	122437781	11414114	31	91											
TNFSF11	8600	broad.mit.edu	37	chr13	43180986	43180986	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagcatcgaggtctccaacCcctccttactggatccggat	8	15	2	0			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr13:43180986C>T	uc001uyu.2	+	5	1035	c.886C>T	c.(886-888)CCC>TCC	p.P296S	TNFSF11_uc001uyt.2_Missense_Mutation_p.P223S	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	296	Extracellular (Potential).				immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		GGTCTCCAACCCCTCCTTACT	0.418													T	43180986	T	T	43180986	3	4	2	1	0	0	0	0	1	0	0	0	16299	623	22	3	904	3	TNFSF11	13	43180986	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08		43180986	71988892	32	92											
RB1	5925	broad.mit.edu	37	chr13	49033967	49033967	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagagacaggcatttggacCaagtaagaaaatcaagcact	10	7	1	3			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr13:49033967C>T	uc001vcb.2	+	20	2270	c.2104C>T	c.(2104-2106)CAA>TAA	p.Q702*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	702	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.Q702*(2)|p.Q702K(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCATTTGGACCAAGTAAGAAA	0.343		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	49033967	T	T	49033967	4	4	2	1	0	0	0	0	0	1	0	0	13098	595	21	3	2182	3	RB1	13	49033967	Nonsense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08	5852981	49033967	66135911	33	93											
HCN4	10021	broad.mit.edu	37	chr15	73614906	73614906	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcagtcagagggggcccCccagaagaggtggctcttgc	15	13	2	3			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr15:73614906C>T	uc002avp.2	-	8	4522	c.3528G>A	c.(3526-3528)GGG>GGA	p.G1176G		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	1176	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		GAGGGGGCCCCCCAGAAGAGG	0.602													T	73614906	T	T	73614906	2	4	2	1	0	0	0	0	0	0	0	1	6999	610	22	3		3	HCN4	15	73614906	Silent	SNP	C	TCGA-02-0033-01A-01D-1490-08		73614906	28916486	34	94											
ACSM5	54988	broad.mit.edu	37	chr16	20439127	20439127	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tagactctctccaaattcccGataaccaccctctgctgtgt	5	15	2	1	rs12922063		TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr16:20439127G>A	uc002dhe.2	+	7	1086	c.939G>A	c.(937-939)CCG>CCA	p.P313P		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	313					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						CCAAATTCCCGATAACCACCC	0.473													A	20439127	A	A	20439127	2	1	2	1	0	0	0	0	0	0	0	1	187	1045	37	2		2	ACSM5	16	20439127	Silent	SNP	G	TCGA-02-0033-01A-01D-1490-08		20439127	69915626	35	95											
ITGAD	3681	broad.mit.edu	37	chr16	31409190	31409190	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctgcctcctgctgggctcGcgctgggagatcatccagac	12	15	1	2			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr16:31409190G>A	uc002ebv.1	+	5	436	c.387G>A	c.(385-387)TCG>TCA	p.S129S	ITGAD_uc010vfl.1_Silent_p.S129S|ITGAD_uc010cap.1_Silent_p.S129S|ITGAD_uc002ebw.1_5'UTR	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	129	FG-GAP 2.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TGCTGGGCTCGCGCTGGGAGA	0.642													A	31409190	A	A	31409190	2	1	2	1	0	0	0	0	0	0	0	1	7884	1074	38	1		1	ITGAD	16	31409190	Silent	SNP	G	TCGA-02-0033-01A-01D-1490-08	10970063	31409190	58945563	36	96											
CETP	1071	broad.mit.edu	37	chr16	57007243	57007243	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgtcctggcttcctccagGgtcatttcatctacaagaat	8	12	3	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr16:57007243G>A	uc002eki.2	+	9	808	c.751G>A	c.(751-753)GGT>AGT	p.G251S	CETP_uc002ekj.2_Intron	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	251					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						CTTCCTCCAGGGTCATTTCAT	0.597													A	57007243	A	A	57007243	3	1	2	1	0	0	0	0	1	0	0	0	3277	1246	43	3	785	3	CETP	16	57007243	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	25598053	57007243	33347510	37	97											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577538	T	T	7577538	3	4	2	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08		7577538	73617672	38	98											
NF1	4763	broad.mit.edu	37	chr17	29586049	29586049	+	Splice_Site	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	taaccctgttttattgtgtaGatacttcagagtattgccaa	7	7	1	2	rs149784315	by1000genomes	TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr17:29586049G>A	uc002hgg.2	+	33	4666	c.4333_splice	c.e33-1	p.I1445_splice	NF1_uc002hgh.2_Splice_Site_p.I1424_splice|NF1_uc002hgi.1_Splice_Site_p.I457_splice	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(4)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTATTGTGTAGATACTTCAGA	0.303			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29586049	A	A	29586049	5	1	2	1	0	0	0	0	0	0	1	0	10356	956	33	3	4523	3	NF1	17	29586049	Splice_Site	SNP	G	TCGA-02-0033-01A-01D-1490-08	22008511	29586049	51609161	39	99											
BZRAP1	9256	broad.mit.edu	37	chr17	56382781	56382781	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcatcgtccatgcccccaaaCacagtaatgacatcccctgc	5	17	1	1	rs149705380	byFrequency	TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr17:56382781C>A	uc002ivx.3	-	29	6271	c.5400G>T	c.(5398-5400)GTG>GTT	p.V1800V	BZRAP1_uc002ivv.2_5'Flank|BZRAP1_uc002ivw.2_Silent_p.V32V|BZRAP1_uc010dcs.2_Silent_p.V1740V|BZRAP1_uc010wnt.1_Silent_p.V1791V	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1800	SH3 3.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGCCCCCAAACACAGTAATGA	0.587													A	56382781	A	A	56382781	2	1	2	1	0	0	0	0	0	0	0	1	1577	465	17	5		5	BZRAP1	17	56382781	Silent	SNP	C	TCGA-02-0033-01A-01D-1490-08	26796732	56382781	24812429	40	100											
ITGB4	3691	broad.mit.edu	37	chr17	73729694	73729694	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcgggcactgtgtgtgctaCggcgaaggccgctacgaggg	18	10	0	0			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr17:73729694C>T	uc002jpg.2	+	13	1765	c.1578C>T	c.(1576-1578)TAC>TAT	p.Y526Y	ITGB4_uc002jph.2_Silent_p.Y526Y|ITGB4_uc010dgo.2_Silent_p.Y526Y|ITGB4_uc002jpi.3_Silent_p.Y526Y|ITGB4_uc010dgp.1_Silent_p.Y526Y|ITGB4_uc002jpj.2_Silent_p.Y526Y|ITGB4_uc010wsh.1_Silent_p.Y81Y	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	526	II.|Extracellular (Potential).|Cysteine-rich tandem repeats.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTGTGTGCTACGGCGAAGGCC	0.642													T	73729694	T	T	73729694	2	4	2	1	0	0	0	0	0	0	0	1	7897	547	19	1		1	ITGB4	17	73729694	Silent	SNP	C	TCGA-02-0033-01A-01D-1490-08	17346913	73729694	7465516	41	101											
C18orf45	85019	broad.mit.edu	37	chr18	20889649	20889649	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgcaaaagacttaccatccCgtggttgcactggtcaggat	10	10	1	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr18:20889649C>T	uc002kuf.2	-	14	934	c.825G>A	c.(823-825)ACG>ACA	p.T275T	C18orf45_uc010xaq.1_RNA|C18orf45_uc010xar.1_RNA|C18orf45_uc002kug.2_RNA|C18orf45_uc002kuh.2_RNA|C18orf45_uc002kue.2_RNA	NM_032933	NP_116322	Q24JQ0	CR045_HUMAN	hypothetical protein LOC85019	275	Helical; (Potential).					integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)					CTTACCATCCCGTGGTTGCAC	0.398													T	20889649	T	T	20889649	2	4	2	1	0	0	0	0	0	0	0	1	1903	639	23	2		2	C18orf45	18	20889649	Silent	SNP	C	TCGA-02-0033-01A-01D-1490-08		20889649	57187599	42	102											
PEX11G	92960	broad.mit.edu	37	chr19	7542216	7542217	+	Frame_Shift_Ins	INS	-	C	C													gcccacagcacgccccggggINScagccagtgcacggcgttgg							TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr19:7542216_7542217insC	uc002mgk.1	-	5	606_607	c.597_598insG	c.(595-600)CTGCCCfs	p.L199fs	PEX11G_uc002mgl.1_Frame_Shift_Ins_p.L129fs	NM_080662	NP_542393	Q96HA9	PX11C_HUMAN	peroxisomal biogenesis factor 11 gamma	199_200	Lumenal (Potential).					integral to membrane|peroxisomal membrane					0						ACGCCCCGGGGCAGCCAGTGCA	0.713													C	7542217	C	C	7542216	7	5	2	1	0	1	1	0	0	0	0	0	11739	1203	42	0	131	0	PEX11G	19	7542216	Frame_Shift_Ins	INS	-	TCGA-02-0033-01A-01D-1490-08		7542216	51586767	43	103											
ZNF99	7652	broad.mit.edu	37	chr19	22940645	22940645	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tatgtttcctaagggctgagAaatggttaaaagccttgcca	10	7	0	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr19:22940645A>T	uc010xrh.1	-	5	1793	c.1793T>A	c.(1792-1794)TTC>TAC	p.F598Y		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAGGGCTGAGAAATGGTTAAA	0.368													T	22940645	T	T	22940645	3	4	2	1	0	0	0	0	1	0	0	0	18201	246	9	5	1331	5	ZNF99	19	22940645	Missense_Mutation	SNP	A	TCGA-02-0033-01A-01D-1490-08	15398429	22940645	36188338	44	104											
KIAA0355	9710	broad.mit.edu	37	chr19	34819037	34819037	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctttaatgagtcggccgccgAcaatctgaaacttaagacgg	10	10	1	3			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr19:34819037A>G	uc002nvd.3	+	6	1944	c.1085A>G	c.(1084-1086)GAC>GGC	p.D362G		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	362										ovary(1)	1	Esophageal squamous(110;0.162)					TCGGCCGCCGACAATCTGAAA	0.512													G	34819037	G	G	34819037	3	3	2	1	0	0	0	0	1	0	0	0	8170	275	10	4	1103	4	KIAA0355	19	34819037	Missense_Mutation	SNP	A	TCGA-02-0033-01A-01D-1490-08	11878392	34819037	24309946	45	105											
DPF1	8193	broad.mit.edu	37	chr19	38713080	38713080	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaacagcgggcggggtacGtgtaaatctgtcccggggcc	15	12	1	0			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr19:38713080G>A	uc002ohl.2	-	3	323	c.296C>T	c.(295-297)ACG>ATG	p.T99M	DPF1_uc002ohm.2_Missense_Mutation_p.T99M|DPF1_uc002ohn.2_Missense_Mutation_p.T17M|DPF1_uc010xtu.1_Missense_Mutation_p.T73M|DPF1_uc010xtv.1_Missense_Mutation_p.T73M|DPF1_uc010xtw.1_Missense_Mutation_p.T73M	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	99					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GGCGGGGTACGTGTAAATCTG	0.517													A	38713080	A	A	38713080	3	1	2	1	0	0	0	0	1	0	0	0	4716	1145	40	1	1018	1	DPF1	19	38713080	Missense_Mutation	SNP	G	TCGA-02-0033-01A-01D-1490-08	3894043	38713080	20415903	46	106											
TAF4	6874	broad.mit.edu	37	chr20	60581775	60581775	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctctgctggatgaaggccgCggagtcgggggtcagctgtc	18	10	2	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr20:60581775C>T	uc002ybs.2	-	7	2014	c.2014G>A	c.(2014-2016)GCG>ACG	p.A672T		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	672	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			ATGAAGGCCGCGGAGTCGGGG	0.662													T	60581775	T	T	60581775	3	4	2	1	0	0	0	0	1	0	0	0	15523	768	27	1	1279	1	TAF4	20	60581775	Missense_Mutation	SNP	C	TCGA-02-0033-01A-01D-1490-08		60581775	2443745	47	107											
KRTAP6-3	337968	broad.mit.edu	37	chr21	31964779	31964779	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccaaggatgacctcaacaacCaacaccatgtgtggcagcta	8	13	1	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chr21:31964779C>A	uc002yom.2	+	1	21	c.15C>A	c.(13-15)ACC>ACA	p.T5T		NM_181605	NP_853636			keratin associated protein 6-3												0						CCTCAACAACCAACACCATGT	0.363													A	31964779	A	A	31964779	2	1	2	1	0	0	0	0	0	0	0	1	8571	581	21	5		5	KRTAP6-3	21	31964779	Silent	SNP	C	TCGA-02-0033-01A-01D-1490-08		31964779	16165116	48	108											
ZNF280C	55609	broad.mit.edu	37	chrX	129370452	129370452	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcatgtttaccttttgacaGcataacttgggaggatgtca	9	7	2	1			TCGA-02-0033-01A-01D-1490-08	TCGA-02-0033-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	39d1f122-31d0-4e1c-95a7-0e65e75b1457	d456abad-4114-4c44-9d80-fe569abe7cda	g.chrX:129370452G>A	uc004evm.2	-	7	809	c.655C>T	c.(655-657)CTG>TTG	p.L219L	ZNF280C_uc010nrf.1_Silent_p.L219L	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	219	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						CCTTTTGACAGCATAACTTGG	0.323													A	129370452	A	A	129370452	2	1	2	1	0	0	0	0	0	0	0	1	17813	962	34	3		3	ZNF280C	23	129370452	Silent	SNP	G	TCGA-02-0033-01A-01D-1490-08		129370452	25900108	49	109											
VPS13D	55187	broad.mit.edu	37	chr1	12418559	12418559	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gattcatccagaaggcatgcCgggctggtgtcagggcttct	14	10	3	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:12418559C>T	uc001atv.2	+	50	10184	c.10043C>T	c.(10042-10044)CCG>CTG	p.P3348L	VPS13D_uc001atw.2_Missense_Mutation_p.P3323L|VPS13D_uc001atx.2_Missense_Mutation_p.P2535L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3347					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GAAGGCATGCCGGGCTGGTGT	0.512													T	12418559	T	T	12418559	3	4	3	1	0	0	0	0	1	0	0	0	17189	652	23	2	10237	2	VPS13D	1	12418559	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08		12418559	236832062	1	110											
RPL11	6135	broad.mit.edu	37	chr1	24018320	24018320	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcctgctctccatcatggcgGtgagtagctgggacctggat	13	11	2	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:24018320G>C	uc001bhk.2	+	1	26	c.6_splice	c.e1+1	p.A2_splice	RPL11_uc001bhl.2_Splice_Site_p.A2_splice|RPL11_uc001bhm.2_5'Flank|RPL11_uc001bhn.1_5'Flank	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11						endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		CATCATGGCGGTGAGTAGCTG	0.607											OREG0013231	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	24018320	C	C	24018320	5	2	3	1	0	0	0	0	0	0	1	0	13557	1275	44	5	9	5	RPL11	1	24018320	Splice_Site	SNP	G	TCGA-02-0047-01A-01D-1490-08	11599761	24018320	225232301	2	111											
LEPR	3953	broad.mit.edu	37	chr1	66083830	66083830	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	taagaagtattatatccatgGtaagtttactatactttagt	6	4	0	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:66083830G>T	uc001dci.2	+	16	2597	c.2395_splice	c.e16+1	p.D799_splice	LEPR_uc001dcg.2_Splice_Site_p.D799_splice|LEPR_uc001dch.2_Splice_Site_p.D799_splice|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Splice_Site_p.D799_splice|LEPR_uc001dck.2_Splice_Site_p.D799_splice	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1						energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TATATCCATGGTAAGTTTACT	0.259													T	66083830	T	T	66083830	5	4	3	1	0	0	0	0	0	0	1	0	8728	1275	44	5	2450	5	LEPR	1	66083830	Splice_Site	SNP	G	TCGA-02-0047-01A-01D-1490-08	42065510	66083830	183166791	3	112											
RPL5	6125	broad.mit.edu	37	chr1	93299218	93299218	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acagagatatcatttgtcagGtaagttgtattctagacagt	9	5	3	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:93299218G>C	uc001doz.2	+	3	267	c.189_splice	c.e3+1	p.Q63_splice	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_Splice_Site|RPL5_uc001dpb.2_Splice_Site_p.Q13_splice|RPL5_uc001dpd.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5						endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		CATTTGTCAGGTAAGTTGTAT	0.393													C	93299218	C	C	93299218	5	2	3	1	0	0	0	0	0	0	1	0	13597	1275	44	5	200	5	RPL5	1	93299218	Splice_Site	SNP	G	TCGA-02-0047-01A-01D-1490-08	27215388	93299218	155951403	4	113											
CD101	9398	broad.mit.edu	37	chr1	117552817	117552817	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	accaaacactgatgagaaatActatggaagttacagtgcaa	8	7	0	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:117552817A>T	uc010oxb.1	+	2	447	c.389A>T	c.(388-390)TAC>TTC	p.Y130F	CD101_uc009whd.2_Missense_Mutation_p.Y130F|CD101_uc010oxc.1_Missense_Mutation_p.Y130F|CD101_uc010oxd.1_Missense_Mutation_p.Y130F	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	130	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GATGAGAAATACTATGGAAGT	0.463													T	117552817	T	T	117552817	3	4	3	1	0	0	0	0	1	0	0	0	2962	391	14	5	395	5	CD101	1	117552817	Missense_Mutation	SNP	A	TCGA-02-0047-01A-01D-1490-08	24253599	117552817	131697804	5	114											
NBPF9	400818	broad.mit.edu	37	chr1	144816536	144816536	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctggaggaatgtgccatcacTtattcaaatagccatggccc	9	11	2	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:144816536T>G	uc009wig.1	+	13	1519	c.1443T>G	c.(1441-1443)ACT>ACG	p.T481T	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Silent_p.T481T|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF9_uc009wii.1_Silent_p.T210T|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Silent_p.T141T	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	481	NBPF 2.					cytoplasm					0						GTGCCATCACTTATTCAAATA	0.463													G	144816536	G	G	144816536	2	3	3	1	0	0	0	0	0	0	0	1	10199	1596	56	5		5	NBPF9	1	144816536	Silent	SNP	T	TCGA-02-0047-01A-01D-1490-08	27263719	144816536	104434085	6	115											
PTPRC	5788	broad.mit.edu	37	chr1	198721383	198721383	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcttcttttatctaggaaatCtgtgctcagtactggggaga	10	7	5	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:198721383C>T	uc001gur.1	+	30	3387	c.3207C>T	c.(3205-3207)ATC>ATT	p.I1069I	PTPRC_uc001gus.1_Silent_p.I1021I|PTPRC_uc001gut.1_Silent_p.I908I	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1069	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TCTAGGAAATCTGTGCTCAGT	0.388													T	198721383	T	T	198721383	2	4	3	1	0	0	0	0	0	0	0	1	12797	903	32	3		3	PTPRC	1	198721383	Silent	SNP	C	TCGA-02-0047-01A-01D-1490-08	53904847	198721383	50529238	7	116											
NAV1	89796	broad.mit.edu	37	chr1	201750337	201750337	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggagaactgaaaaagcccatCagcctgggccaccctggttc	11	13	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:201750337C>T	uc001gwu.2	+	5	1910	c.1563C>T	c.(1561-1563)ATC>ATT	p.I521I	NAV1_uc001gwv.1_Silent_p.I29I|NAV1_uc001gww.1_Silent_p.I130I|NAV1_uc001gwx.2_Silent_p.I130I|NAV1_uc001gwy.1_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	521					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						AAAAGCCCATCAGCCTGGGCC	0.577													T	201750337	T	T	201750337	2	4	3	1	0	0	0	0	0	0	0	1	10183	816	29	3		3	NAV1	1	201750337	Silent	SNP	C	TCGA-02-0047-01A-01D-1490-08	3028954	201750337	47500284	8	117											
PCNXL2	80003	broad.mit.edu	37	chr1	233395011	233395011	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagcatgtgtgcttgagaCgcaggtaagctttccacttt	10	10	0	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:233395011C>T	uc001hvl.2	-	5	832	c.597G>A	c.(595-597)GCG>GCA	p.A199A	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	199						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GTGCTTGAGACGCAGGTAAGC	0.448													T	233395011	T	T	233395011	2	4	3	1	0	0	0	0	0	0	0	1	11592	523	19	1		1	PCNXL2	1	233395011	Silent	SNP	C	TCGA-02-0047-01A-01D-1490-08	31644674	233395011	15855610	9	118											
RYR2	6262	broad.mit.edu	37	chr1	237794836	237794836	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgtccttggaggtggagagTccaaggtaacgtctttgatt	13	7	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr1:237794836T>C	uc001hyl.1	+	42	6670	c.6550T>C	c.(6550-6552)TCC>CCC	p.S2184P		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2184	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGGTGGAGAGTCCAAGGTAAC	0.393													C	237794836	C	C	237794836	3	2	3	1	0	0	0	0	1	0	0	0	13769	1667	58	4	6716	4	RYR2	1	237794836	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	4399825	237794836	11455785	10	119											
SPTBN1	6711	broad.mit.edu	37	chr2	54852086	54852086	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggctgagcgaaaaccagcGtctggtgtctcaggttctgc	13	10	3	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr2:54852086G>A	uc002rxu.2	+	11	1577	c.1328G>A	c.(1327-1329)CGT>CAT	p.R443H	SPTBN1_uc002rxv.1_Missense_Mutation_p.R443H|SPTBN1_uc002rxx.2_Missense_Mutation_p.R430H	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	443	Spectrin 2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GAAAACCAGCGTCTGGTGTCT	0.507													A	54852086	A	A	54852086	3	1	3	1	0	0	0	0	1	0	0	0	15118	1145	40	1	1479	1	SPTBN1	2	54852086	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08		54852086	188347287	11	120											
BCL11A	53335	broad.mit.edu	37	chr2	60688379	60688379	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggaaggcctcgctgaagtgCtgcatggagctgagcaccat	14	10	0	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr2:60688379C>G	uc002sae.1	-	4	1896	c.1668G>C	c.(1666-1668)CAG>CAC	p.Q556H	BCL11A_uc002sab.2_Missense_Mutation_p.Q556H|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.Q225H|BCL11A_uc010ypj.1_Missense_Mutation_p.Q522H|BCL11A_uc002sad.1_Missense_Mutation_p.Q404H|BCL11A_uc002saf.1_Missense_Mutation_p.Q522H	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	556					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CGCTGAAGTGCTGCATGGAGC	0.697			T	IGH@	B-CLL								G	60688379	G	G	60688379	3	3	3	1	0	0	0	0	1	0	0	0	1363	796	28	5	949	5	BCL11A	2	60688379	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	5836293	60688379	182510994	12	121											
SLC9A4	389015	broad.mit.edu	37	chr2	103095487	103095487	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggctacttcatgcccacccGgcccttctttgagaacatcg	8	16	2	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr2:103095487G>A	uc002tbz.3	+	2	903	c.446G>A	c.(445-447)CGG>CAG	p.R149Q		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	149	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						ATGCCCACCCGGCCCTTCTTT	0.597													A	103095487	A	A	103095487	3	1	3	1	0	0	0	0	1	0	0	0	14716	1116	39	2	452	2	SLC9A4	2	103095487	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	42407108	103095487	140103886	13	122											
IL1B	3553	broad.mit.edu	37	chr2	113588108	113588108	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcttgttgaagacaaatcGcttttccatcttcttctttg	5	9	4	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr2:113588108G>A	uc002tii.1	-	7	727	c.640C>T	c.(640-642)CGA>TGA	p.R214*	IL1B_uc002tih.1_Nonsense_Mutation_p.R183*	NM_000576	NP_000567	P01584	IL1B_HUMAN	interleukin 1, beta proprotein	214					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			lung(3)|breast(1)	4					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	AAGACAAATCGCTTTTCCATC	0.423													A	113588108	A	A	113588108	4	1	3	1	0	0	0	0	0	1	0	0	7651	1095	38	1	173	1	IL1B	2	113588108	Nonsense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	10492621	113588108	129611265	14	123											
TUBA4A	7277	broad.mit.edu	37	chr2	220116339	220116339	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgatctccttgccaatggtaTagtgaccacgggcatagttg	11	9	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr2:220116339T>C	uc002vkt.1	-	3	381	c.323A>G	c.(322-324)TAT>TGT	p.Y108C	TUBA4A_uc010zkz.1_Missense_Mutation_p.Y93C|TUBA4B_uc002vku.2_5'Flank|TUBA4B_uc002vkv.1_5'Flank	NM_006000	NP_005991	P68366	TBA4A_HUMAN	tubulin, alpha 4a	108					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)	3		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCAATGGTATAGTGACCACG	0.532													C	220116339	C	C	220116339	3	2	3	1	0	0	0	0	1	0	0	0	16746	1406	49	4	1031	4	TUBA4A	2	220116339	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	106528231	220116339	23083034	15	124											
DES	1674	broad.mit.edu	37	chr2	220286104	220286104	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgcgggaattggaggaccgaTttgccagtgaggccagtggc	17	8	0	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr2:220286104T>A	uc002vll.2	+	6	1152	c.1066T>A	c.(1066-1068)TTT>ATT	p.F356I		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	356	Rod.|Coil 2B.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton	p.F356I(1)		central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		GGAGGACCGATTTGCCAGTGA	0.587													A	220286104	A	A	220286104	3	1	3	1	0	0	0	0	1	0	0	0	4449	1493	52	5	1088	5	DES	2	220286104	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	169765	220286104	22913269	16	125											
COL4A4	1286	broad.mit.edu	37	chr2	227886828	227886828	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggtcctctcatgcctggCgccccaggaaggcctgggat	13	14	2	0	rs75398993	by1000genomes	TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr2:227886828C>T	uc010zlt.1	-	43	4806	c.4152G>A	c.(4150-4152)GCG>GCA	p.A1384A		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1384	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCATGCCTGGCGCCCCAGGAA	0.567													T	227886828	T	T	227886828	2	4	3	1	0	0	0	0	0	0	0	1	3693	755	27	1		1	COL4A4	2	227886828	Silent	SNP	C	TCGA-02-0047-01A-01D-1490-08	7600724	227886828	15312545	17	126											
ZNF385D	79750	broad.mit.edu	37	chr3	21462765	21462765	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgggtccaggagctggccGcaggagtgccggaggaagcg	19	9	0	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr3:21462765G>A	uc003cce.2	-	8	1537	c.1129C>T	c.(1129-1131)CGG>TGG	p.R377W		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	377						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GGAGCTGGCCGCAGGAGTGCC	0.453													A	21462765	A	A	21462765	3	1	3	1	0	0	0	0	1	0	0	0	17875	1086	38	1	62	1	ZNF385D	3	21462765	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08		21462765	176559665	18	127											
PIK3CA	5290	broad.mit.edu	37	chr3	178921553	178921553	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctttgtgcaacctacgtgaaTgtaaatattcgagacattga	8	7	0	3	rs121913284		TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr3:178921553T>A	uc003fjk.2	+	5	1192	c.1035T>A	c.(1033-1035)AAT>AAA	p.N345K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	345					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N345K(29)|p.N345I(2)|p.N345S(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCTACGTGAATGTAAATATTC	0.308		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178921553	A	A	178921553	3	1	3	1	0	0	0	0	1	0	0	0	11913	1461	51	5	1049	5	PIK3CA	3	178921553	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	157458788	178921553	19100877	19	128											
PDGFRA	5156	broad.mit.edu	37	chr4	55152112	55152113	+	In_Frame_Ins	INS	-	TTT	TTT													acatcatgcatgattcgaacINStatgtgtcgaaaggcagtgt							TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr4:55152112_55152113insTTT	uc003han.3	+	18	2875_2876	c.2544_2545insTTT	c.(2542-2547)insTTT	p.848_849insF	PDGFRA_uc003haa.2_In_Frame_Ins_p.608_609insF	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	848_849	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity	p.H845_N848>P(3)|p.N848K(1)|p.H845_N848del(1)		soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	ATGATTCGAACTATGTGTCGAA	0.495			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			TTT	55152113	TTT	TTT	55152112	7	5	3	1	0	1	1	0	0	0	0	0	11661	564	20	0	2610	0	PDGFRA	4	55152112	In_Frame_Ins	INS	-	TCGA-02-0047-01A-01D-1490-08		55152112	136002164	20	129											
EPHA5	2044	broad.mit.edu	37	chr4	66467624	66467624	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcaatgcaagcaccaacatcTtgaaaagcaagataaaatcc	6	10	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr4:66467624T>A	uc003hcy.2	-	3	838	c.645A>T	c.(643-645)CAA>CAT	p.Q215H	EPHA5_uc003hcx.2_Missense_Mutation_p.Q146H|EPHA5_uc003hcz.2_Missense_Mutation_p.Q215H|EPHA5_uc011cah.1_Missense_Mutation_p.Q215H|EPHA5_uc011cai.1_Missense_Mutation_p.Q215H|EPHA5_uc003hda.2_Missense_Mutation_p.Q215H	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	215	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CACCAACATCTTGAAAAGCAA	0.428										TSP Lung(17;0.13)			A	66467624	A	A	66467624	3	1	3	1	0	0	0	0	1	0	0	0	5170	1606	56	5	2532	5	EPHA5	4	66467624	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	11315512	66467624	124686652	21	130											
FGA	2243	broad.mit.edu	37	chr4	155507575	155507575	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccagttccagagctcccagAgttccagcttccagtacttc	7	15	0	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr4:155507575A>G	uc003iod.1	-	5	1064	c.1006T>C	c.(1006-1008)TCT>CCT	p.S336P	FGA_uc003ioe.1_Missense_Mutation_p.S336P|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	336	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GAGCTCCCAGAGTTCCAGCTT	0.567													G	155507575	G	G	155507575	3	3	3	1	0	0	0	0	1	0	0	0	5830	304	11	4	1646	4	FGA	4	155507575	Missense_Mutation	SNP	A	TCGA-02-0047-01A-01D-1490-08	89039951	155507575	35646701	22	131											
FBXO8	26269	broad.mit.edu	37	chr4	175180976	175180976	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccccaagtggatttgcacaaCctataaaatcagagaaaatg	7	9	1	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr4:175180976C>A	uc003itp.2	-	3	1180	c.330G>T	c.(328-330)GGG>GGT	p.G110G	FBXO8_uc003itq.2_Silent_p.G69G	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	110	F-box.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		ATTTGCACAACCTATAAAATC	0.318													A	175180976	A	A	175180976	2	1	3	1	0	0	0	0	0	0	0	1	5761	521	18	5		5	FBXO8	4	175180976	Silent	SNP	C	TCGA-02-0047-01A-01D-1490-08	19673401	175180976	15973300	23	132											
WWC2	80014	broad.mit.edu	37	chr4	184201980	184201980	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cagctgagttgttagctgtgGaacaagaattagcacaagaa	11	6	0	3			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr4:184201980G>C	uc010irx.2	+	17	2796	c.2614G>C	c.(2614-2616)GAA>CAA	p.E872Q	WWC2_uc003ivk.3_Missense_Mutation_p.E667Q|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.E554Q|WWC2_uc003ivn.3_Missense_Mutation_p.E387Q|WWC2_uc010irz.2_Missense_Mutation_p.E189Q|WWC2_uc003ivo.3_5'Flank	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	872	Potential.									ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		GTTAGCTGTGgaacaagaatt	0.318													C	184201980	C	C	184201980	3	2	3	1	0	0	0	0	1	0	0	0	17409	1175	41	5	2680	5	WWC2	4	184201980	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	9021004	184201980	6952296	24	133											
GFM2	84340	broad.mit.edu	37	chr5	74028894	74028894	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcaaactgggatcttcacGctgaagacatttcaacgcat	7	10	4	2	rs139234343		TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr5:74028894G>A	uc003kdh.1	-	16	1844	c.1540C>T	c.(1540-1542)CGT>TGT	p.R514C	GFM2_uc003kdi.1_Missense_Mutation_p.R467C|GFM2_uc010izj.1_Missense_Mutation_p.R546C|GFM2_uc010izk.1_RNA	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	514					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		GGATCTTCACGCTGAAGACAT	0.289													A	74028894	A	A	74028894	3	1	3	1	0	0	0	0	1	0	0	0	6342	1087	38	1	823	1	GFM2	5	74028894	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08		74028894	106886366	25	134											
GFM2	84340	broad.mit.edu	37	chr5	74041590	74041590	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggggctttctctcaaagtcTtttccatcatttgaattgca	7	9	4	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr5:74041590T>C	uc003kdh.1	-	10	1066	c.762A>G	c.(760-762)AAA>AAG	p.K254K	GFM2_uc003kdi.1_Silent_p.K254K|GFM2_uc010izj.1_Silent_p.K286K|GFM2_uc010izk.1_RNA|GFM2_uc003kdj.1_Silent_p.K254K|GFM2_uc010izl.1_Silent_p.K212K	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	254					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		TCTCAAAGTCTTTTCCATCAT	0.358													C	74041590	C	C	74041590	2	2	3	1	0	0	0	0	0	0	0	1	6342	1606	56	4		4	GFM2	5	74041590	Silent	SNP	T	TCGA-02-0047-01A-01D-1490-08	12696	74041590	106873670	26	135											
PCDHGA8	9708	broad.mit.edu	37	chr5	140774103	140774103	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacagacggttccactggcGtggagctggcgccccgctcc	13	17	0	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr5:140774103G>A	uc003lkd.1	+	1	2621	c.1723G>A	c.(1723-1725)GTG>ATG	p.V575M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.V575M	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	575	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCACTGGCGTGGAGCTGGC	0.657													A	140774103	A	A	140774103	3	1	3	1	0	0	0	0	1	0	0	0	11560	1145	40	1	1725	1	PCDHGA8	5	140774103	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	66732513	140774103	40141157	27	136											
ADAMTS2	9509	broad.mit.edu	37	chr5	178556976	178556976	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggggcccatggtctgcagcGtctcccggccgtcctcgtct	14	16	3	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr5:178556976G>A	uc003mjw.2	-	16	2414	c.2414C>T	c.(2413-2415)ACG>ATG	p.T805M		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	805	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GGTCTGCAGCGTCTCCCGGCC	0.607													A	178556976	A	A	178556976	3	1	3	1	0	0	0	0	1	0	0	0	265	1145	40	1	1249	1	ADAMTS2	5	178556976	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	37782873	178556976	2358284	28	137											
ADAMTS2	9509	broad.mit.edu	37	chr5	178585775	178585775	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtgaggaagatggcgtgatCgtggtattcatcgtggcccg	16	7	1	3			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr5:178585775C>T	uc003mjw.2	-	6	1081	c.1081G>A	c.(1081-1083)GAT>AAT	p.D361N	ADAMTS2_uc011dgm.1_Missense_Mutation_p.D361N	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	361	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		ATGGCGTGATCGTGGTATTCA	0.607													T	178585775	T	T	178585775	3	4	3	1	0	0	0	0	1	0	0	0	265	884	31	2	2697	2	ADAMTS2	5	178585775	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	28799	178585775	2329485	29	138											
TREML2	79865	broad.mit.edu	37	chr6	41162491	41162491	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcatcagggcctgaggtagGggcttggccagttgtgacag	18	8	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr6:41162491G>A	uc010jxm.1	-	3	636	c.457C>T	c.(457-459)CCT>TCT	p.P153S		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	153	Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCTGAGGTAGGGGCTTGGCCA	0.542													A	41162491	A	A	41162491	3	1	3	1	0	0	0	0	1	0	0	0	16470	1232	43	3	520	3	TREML2	6	41162491	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08		41162491	129952576	30	139											
DEFB110	245913	broad.mit.edu	37	chr6	49976918	49976918	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	actcaacatcatcacaaaacGttttacatattcctctcact	1	13	4	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr6:49976918G>T	uc011dwr.1	-	2	168	c.122C>A	c.(121-123)ACG>AAG	p.T41K		NM_001037728	NP_001032817	Q30KQ9	DB110_HUMAN	beta-defensin 110 isoform b	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					ATCACAAAACGTTTTACATAT	0.333													T	49976918	T	T	49976918	3	4	3	1	0	0	0	0	1	0	0	0	4400	1145	40	5	68	5	DEFB110	6	49976918	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	8814427	49976918	121138149	31	140											
FAM83B	222584	broad.mit.edu	37	chr6	54791195	54791195	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctttagtgatggatatattTacagatgtggacattttcaa	9	4	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr6:54791195T>C	uc003pck.2	+	3	587	c.471T>C	c.(469-471)TTT>TTC	p.F157F		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	157										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TGGATATATTTACAGATGTGG	0.299													C	54791195	C	C	54791195	2	2	3	1	0	0	0	0	0	0	0	1	5634	1751	61	4		4	FAM83B	6	54791195	Silent	SNP	T	TCGA-02-0047-01A-01D-1490-08	4814277	54791195	116323872	32	141											
LAMA2	3908	broad.mit.edu	37	chr6	129371087	129371087	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	attccctgctgtcctgaatcTtgcttctaatgctcttatca	5	12	4	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr6:129371087T>A	uc003qbn.2	+	2	242	c.137T>A	c.(136-138)CTT>CAT	p.L46H	LAMA2_uc003qbo.2_Missense_Mutation_p.L46H	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	46	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GTCCTGAATCTTGCTTCTAAT	0.403													A	129371087	A	A	129371087	3	1	3	1	0	0	0	0	1	0	0	0	8606	1609	56	5	143	5	LAMA2	6	129371087	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	74579892	129371087	41743980	33	142											
SASH1	23328	broad.mit.edu	37	chr6	148865365	148865365	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaatcgcagcctctggtcGcggcctgtcaccccctcagt	9	18	4	0	rs145411864		TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr6:148865365G>A	uc003qme.1	+	18	3234	c.2759G>A	c.(2758-2760)CGC>CAC	p.R920H	SASH1_uc011eeb.1_Missense_Mutation_p.R681H|SASH1_uc003qmf.1_Missense_Mutation_p.R330H	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	920							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GCCTCTGGTCGCGGCCTGTCA	0.517													A	148865365	A	A	148865365	3	1	3	1	0	0	0	0	1	0	0	0	13848	1087	38	1	2829	1	SASH1	6	148865365	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	19494278	148865365	22249702	34	143											
PLEKHG1	57480	broad.mit.edu	37	chr6	151152163	151152163	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacagccccaaaacagaagGgcaggaggagatgactccct	12	11	0	3			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr6:151152163G>A	uc003qny.1	+	16	2228	c.1916G>A	c.(1915-1917)GGG>GAG	p.G639E	PLEKHG1_uc011eel.1_Missense_Mutation_p.G679E|PLEKHG1_uc011eem.1_Missense_Mutation_p.G698E|PLEKHG1_uc003qnz.2_Missense_Mutation_p.G639E	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	639					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		AAAACAGAAGGGCAGGAGGAG	0.478													A	151152163	A	A	151152163	3	1	3	1	0	0	0	0	1	0	0	0	12068	1232	43	3	1970	3	PLEKHG1	6	151152163	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	2286798	151152163	19962904	35	144											
PLG	5340	broad.mit.edu	37	chr6	161173177	161173177	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctggccttctcaaggaagCccagctccctgtgattgaga	11	12	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr6:161173177C>T	uc003qtm.3	+	18	2219	c.2156C>T	c.(2155-2157)GCC>GTC	p.A719V		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	719	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CTCAAGGAAGCCCAGCTCCCT	0.468													T	161173177	T	T	161173177	3	4	3	1	0	0	0	0	1	0	0	0	12086	739	26	3	2230	3	PLG	6	161173177	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	10021014	161173177	9941890	36	145											
GAL3ST4	79690	broad.mit.edu	37	chr7	99758263	99758263	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgggattgagggtttgggctCgagggccagcaccagaaggc	18	8	0	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr7:99758263C>T	uc003utt.2	-	3	1766	c.749G>A	c.(748-750)CGA>CAA	p.R250Q	C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.R250Q|GAL3ST4_uc010lgq.2_Missense_Mutation_p.R188Q	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	250	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGTTTGGGCTCGAGGGCCAGC	0.567													T	99758263	T	T	99758263	3	4	3	1	0	0	0	0	1	0	0	0	6200	884	31	2	715	2	GAL3ST4	7	99758263	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08		99758263	59380400	37	146											
BRAF	673	broad.mit.edu	37	chr7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acccactccatcgagatttcActgtagctagaccaaaatca	5	13	2	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				T	140453136	T	T	140453136	3	4	3	1	0	0	0	0	1	0	0	0	1496	159	6	5	517	5	BRAF	7	140453136	Missense_Mutation	SNP	A	TCGA-02-0047-01A-01D-1490-08	40694873	140453136	18685527	38	147											
FAM86B2	653333	broad.mit.edu	37	chr8	12286307	12286307	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccctcggagctgctcgaggaTccggctgtgagggtcgctga	16	12	0	2	rs148161726		TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr8:12286307T>C	uc003wvt.3	-	6	577	c.577A>G	c.(577-579)ATC>GTC	p.I193V	FAM66D_uc011kxp.1_Intron|uc003wvm.1_Intron|FAM86B2_uc003wvq.3_Intron|FAM86B2_uc003wvr.3_Missense_Mutation_p.I16V|FAM86B2_uc003wvs.3_Missense_Mutation_p.I93V|FAM86B2_uc010lsn.2_Intron|FAM86B2_uc003wvu.3_Intron|FAM86B2_uc010lso.2_Intron|FAM86B2_uc011kxt.1_Intron|FAM86B2_uc011kxu.1_Intron|FAM86B2_uc010lsl.2_Intron	NM_001137610	NP_001131082	P0C5J1	F86B2_HUMAN	hypothetical protein LOC653333	193											0						TGCTCGAGGATCCGGCTGTGA	0.602													C	12286307	C	C	12286307	3	2	3	1	0	0	0	0	1	0	0	0	5645	1435	50	4	427	4	FAM86B2	8	12286307	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08		12286307	134077715	39	148											
ASAH1	427	broad.mit.edu	37	chr8	17916969	17916969	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccatctaccctgcttagcatCgagtctagatacaaaaggag	8	11	2	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr8:17916969C>T	uc003wyl.2	-	12	1234	c.922G>A	c.(922-924)GAT>AAT	p.D308N	ASAH1_uc010ltb.1_RNA|ASAH1_uc003wym.2_Missense_Mutation_p.D283N|ASAH1_uc003wyn.2_Missense_Mutation_p.D324N|ASAH1_uc003wyo.2_Missense_Mutation_p.D302N	NM_177924	NP_808592	Q13510	ASAH1_HUMAN	N-acylsphingosine amidohydrolase 1 isoform a	308					ceramide metabolic process	lysosome	ceramidase activity				0				Colorectal(111;0.0646)|COAD - Colon adenocarcinoma(73;0.228)		TGCTTAGCATCGAGTCTAGAT	0.398													T	17916969	T	T	17916969	3	4	3	1	0	0	0	0	1	0	0	0	1006	884	31	2	277	2	ASAH1	8	17916969	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	5630662	17916969	128447053	40	149											
DNAJC5B	85479	broad.mit.edu	37	chr8	66963845	66963845	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaacaggagaagctctataCgaaattcttggtctgcataa	8	8	3	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr8:66963845C>T	uc003xvs.1	+	3	354	c.63C>T	c.(61-63)TAC>TAT	p.Y21Y	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	21	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			AAGCTCTATACGAAATTCTTG	0.398													T	66963845	T	T	66963845	2	4	3	1	0	0	0	0	0	0	0	1	4651	547	19	1		1	DNAJC5B	8	66963845	Silent	SNP	C	TCGA-02-0047-01A-01D-1490-08	49046876	66963845	79400177	41	150											
RNF19A	25897	broad.mit.edu	37	chr8	101273881	101273881	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtctcggatggctcctattCgatccatgtggcttccactt	9	12	1	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr8:101273881C>T	uc003yjj.1	-	9	1888	c.1571G>A	c.(1570-1572)CGA>CAA	p.R524Q	RNF19A_uc003yjk.1_Missense_Mutation_p.R524Q	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	524					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			GGCTCCTATTCGATCCATGTG	0.532													T	101273881	T	T	101273881	3	4	3	1	0	0	0	0	1	0	0	0	13470	884	31	2	957	2	RNF19A	8	101273881	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	34310036	101273881	45090141	42	151											
GPR158	57512	broad.mit.edu	37	chr10	25886887	25886887	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aagaggacaaggagggcgccGaccatggcacagccaaaggc	15	11	0	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr10:25886887G>T	uc001isj.2	+	11	2392	c.2332G>T	c.(2332-2334)GAC>TAC	p.D778Y	GPR158_uc001isk.2_Missense_Mutation_p.D153Y	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	778	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GGAGGGCGCCGACCATGGCAC	0.567													T	25886887	T	T	25886887	3	4	3	1	0	0	0	0	1	0	0	0	6663	1058	37	5	2374	5	GPR158	10	25886887	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08		25886887	109647860	43	152			1	1		2	2	19	G		4.94226e-05
GPR158	57512	broad.mit.edu	37	chr10	25886905	25886905	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccgaccatggcacagccaaaGgcactgccctcatcaggaag	10	15	2	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr10:25886905G>C	uc001isj.2	+	11	2410	c.2350G>C	c.(2350-2352)GGC>CGC	p.G784R	GPR158_uc001isk.2_Missense_Mutation_p.G159R	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	784	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CACAGCCAAAGGCACTGCCCT	0.547													C	25886905	C	C	25886905	3	2	3	1	0	0	0	0	1	0	0	0	6663	1000	35	5	2392	5	GPR158	10	25886905	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	18	25886905	109647842	44	153			1	1		2	2	19	G		4.94226e-05
MYO3A	53904	broad.mit.edu	37	chr10	26446423	26446423	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aggattctcccatcggatacTttttgctaactttataaagc	6	9	1	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr10:26446423T>A	uc001isn.2	+	26	3338	c.2978T>A	c.(2977-2979)CTT>CAT	p.L993H	MYO3A_uc009xko.1_Missense_Mutation_p.L993H|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	993	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						CATCGGATACTTTTTGCTAAC	0.333													A	26446423	A	A	26446423	3	1	3	1	0	0	0	0	1	0	0	0	10076	1609	56	5	3072	5	MYO3A	10	26446423	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	559518	26446423	109088324	45	154											
CXCL12	6387	broad.mit.edu	37	chr10	44876321	44876321	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catctgtagctcaggctgacGggcttccctagaagaggtaa	12	10	2	3			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr10:44876321G>A	uc001jbf.2	-	2	158	c.69C>T	c.(67-69)CCC>CCT	p.P23P	CXCL12_uc001jbh.2_Silent_p.P23P|CXCL12_uc001jbi.2_Silent_p.P23P	NM_000609	NP_000600	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12 (stromal	23					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity				0					Dexamethasone(DB01234)	TCAGGCTGACGGGCTTCCCTA	0.507													A	44876321	A	A	44876321	2	1	3	1	0	0	0	0	0	0	0	1	4080	1103	39	2		2	CXCL12	10	44876321	Silent	SNP	G	TCGA-02-0047-01A-01D-1490-08	18429898	44876321	90658426	46	155											
OR52I2	143502	broad.mit.edu	37	chr11	4609074	4609074	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgatgcatgtcctctttgaCcattccaacctgggttcatg	8	12	2	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr11:4609074C>A	uc010qyh.1	+	1	1032	c.1032C>A	c.(1030-1032)GAC>GAA	p.D344E		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	344	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCTCTTTGACCATTCCAACC	0.453													A	4609074	A	A	4609074	3	1	3	1	0	0	0	0	1	0	0	0	11121	506	18	5	1034	5	OR52I2	11	4609074	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08		4609074	130397442	47	156											
TEAD1	7003	broad.mit.edu	37	chr11	12946585	12946585	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcctttgggaagcaagtaGtagaaaaagtagaggtaagt	13	4	0	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr11:12946585G>A	uc001mkj.3	+	11	1620	c.955G>A	c.(955-957)GTA>ATA	p.V319I	TEAD1_uc001mkk.3_Missense_Mutation_p.V238I|TEAD1_uc009ygl.2_Missense_Mutation_p.V155I	NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	334	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GAAGCAAGTAGTAGAAAAAGT	0.438													A	12946585	A	A	12946585	3	1	3	1	0	0	0	0	1	0	0	0	15735	1029	36	3	1034	3	TEAD1	11	12946585	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	8337511	12946585	122059931	48	157											
OR5M3	219482	broad.mit.edu	37	chr11	56237516	56237516	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ataatgttgctgccagactcGtcagaaaaccataaatgtaa	7	8	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr11:56237516G>A	uc010rjk.1	-	1	458	c.458C>T	c.(457-459)ACG>ATG	p.T153M		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGCCAGACTCGTCAGAAAACC	0.413													A	56237516	A	A	56237516	3	1	3	1	0	0	0	0	1	0	0	0	11175	1145	40	1	467	1	OR5M3	11	56237516	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	43290931	56237516	78769000	49	158											
SCYL1	57410	broad.mit.edu	37	chr11	65303487	65303487	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggacccgtttgcaccgtccCgggttgcgggtgtcctgggc	17	13	0	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr11:65303487C>T	uc001oea.1	+	11	1527	c.1450C>T	c.(1450-1452)CGG>TGG	p.R484W	SCYL1_uc009yqk.2_Missense_Mutation_p.R484W|SCYL1_uc001oeb.1_Missense_Mutation_p.R484W|SCYL1_uc001oec.1_Missense_Mutation_p.R484W|SCYL1_uc001oed.1_Missense_Mutation_p.R341W|SCYL1_uc001oee.1_Missense_Mutation_p.R128W	NM_020680	NP_065731	Q96KG9	NTKL_HUMAN	SCY1-like 1 isoform A	484					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			skin(1)	1						TGCACCGTCCCGGGTTGCGGG	0.597													T	65303487	T	T	65303487	3	4	3	1	0	0	0	0	1	0	0	0	13947	643	23	2	1492	2	SCYL1	11	65303487	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	9065971	65303487	69703029	50	159											
FAT3	120114	broad.mit.edu	37	chr11	92568240	92568240	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agacgccttggtgggagactCtgtcattttggtaggtacct	13	8	2	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr11:92568240C>T	uc001pdj.3	+	14	10093	c.10076C>T	c.(10075-10077)TCT>TTT	p.S3359F		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3359	Extracellular (Potential).|Cadherin 31.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGGAGACTCTGTCATTTTG	0.468										TCGA Ovarian(4;0.039)			T	92568240	T	T	92568240	3	4	3	1	0	0	0	0	1	0	0	0	5691	913	32	3	10130	3	FAT3	11	92568240	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	27264753	92568240	42438276	51	160											
EXPH5	23086	broad.mit.edu	37	chr11	108380635	108380635	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acctgtttttgtcccgctgcGataagcccaactttcatttc	6	13	1	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr11:108380635G>A	uc001pkk.2	-	6	5710	c.5599C>T	c.(5599-5601)CGC>TGC	p.R1867C	EXPH5_uc010rvy.1_Missense_Mutation_p.R1679C|EXPH5_uc010rvz.1_Missense_Mutation_p.R1711C|EXPH5_uc010rwa.1_Missense_Mutation_p.R1791C	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1867					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GTCCCGCTGCGATAAGCCCAA	0.428													A	108380635	A	A	108380635	3	1	3	1	0	0	0	0	1	0	0	0	5322	1058	37	2	374	2	EXPH5	11	108380635	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	15812395	108380635	26625881	52	161											
DDX6	1656	broad.mit.edu	37	chr11	118626197	118626197	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacagcttgtatatcaataCctcgggtaaacagatcttaa	6	9	3	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr11:118626197C>T	uc001pub.2	-	12	1551	c.1190G>A	c.(1189-1191)GGT>GAT	p.G397D	DDX6_uc001pua.2_Missense_Mutation_p.G97D|DDX6_uc001puc.2_Missense_Mutation_p.G397D	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	397	Helicase C-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		TATATCAATACCTCGGGTAAA	0.323			T	IGH@	B-NHL								T	118626197	T	T	118626197	3	4	3	1	0	0	0	0	1	0	0	0	4377	507	18	3	269	3	DDX6	11	118626197	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	10245562	118626197	16380319	53	162											
B4GALNT3	283358	broad.mit.edu	37	chr12	662979	662979	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacgtacctgtgtttgacccGgtagtaaactgggaccagac	11	10	0	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr12:662979G>A	uc001qii.1	+	14	1890	c.1890G>A	c.(1888-1890)CCG>CCA	p.P630P	B4GALNT3_uc001qij.1_Silent_p.P533P|B4GALNT3_uc001qik.1_Silent_p.P179P	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	630	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			TGTTTGACCCGGTAGTAAACT	0.423													A	662979	A	A	662979	2	1	3	1	0	0	0	0	0	0	0	1	1268	1103	39	2		2	B4GALNT3	12	662979	Silent	SNP	G	TCGA-02-0047-01A-01D-1490-08		662979	133188916	54	163											
CLSTN3	9746	broad.mit.edu	37	chr12	7294683	7294683	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttttttttttatccccagaGgagaagaacaaagagaagga	9	5	0	4			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr12:7294683G>A	uc001qsr.2	+	10	1766	c.1488G>A	c.(1486-1488)GAG>GAA	p.E496E	CLSTN3_uc001qss.2_Silent_p.E508E	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	496	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						TATCCCCAGAGGAGAAGAACA	0.453											OREG0021650	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	7294683	A	A	7294683	2	1	3	1	0	0	0	0	0	0	0	1	3563	1014	35	3		3	CLSTN3	12	7294683	Silent	SNP	G	TCGA-02-0047-01A-01D-1490-08	6631704	7294683	126557212	55	164											
RIMKLB	57494	broad.mit.edu	37	chr12	8926145	8926162	+	In_Frame_Del	DEL	CTGGCCGGCTCACCCGGC	-	-													tgccgcctcccttctaccctCtggccggctcacccggcgta					rs34259191		TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr12:8926145_8926162delCTGGCCGGCTCACCCGGC	uc001quu.2	+	6	1177_1194	c.926_943delCTGGCCGGCTCACCCGGC	c.(925-945)TCTGGCCGGCTCACCCGGCGT>TGT	p.309_315SGRLTRR>C	RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_In_Frame_Del_p.309_315SGRLTRR>C|RIMKLB_uc010sgl.1_In_Frame_Del_p.309_315SGRLTRR>C|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	309_315					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CTTCTACCCTCTGGCCGGCTCACCCGGCGTATGTCCCT	0.55													-	8926162	-	-	8926145	7	5	3	1	0	1	0	1	0	0	0	0	13366	913	32	0	944	0	RIMKLB	12	8926145	In_Frame_Del	DEL	CTGGCCGGCTCACCCGGC	TCGA-02-0047-01A-01D-1490-08	1631462	8926145	124925750	56	165											
BCL2L14	79370	broad.mit.edu	37	chr12	12247837	12247837	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctgaaagagaacttctcGccatggatccagcagcacgg	10	12	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr12:12247837G>A	uc001rac.2	+	5	1119	c.918G>A	c.(916-918)TCG>TCA	p.S306S	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_Intron|BCL2L14_uc001rad.2_Silent_p.S306S|BCL2L14_uc001rae.2_3'UTR	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	306					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		AGAACTTCTCGCCATGGATCC	0.448													A	12247837	A	A	12247837	2	1	3	1	0	0	0	0	0	0	0	1	1372	1074	38	1		1	BCL2L14	12	12247837	Silent	SNP	G	TCGA-02-0047-01A-01D-1490-08	3321692	12247837	121604058	57	166											
LRP6	4040	broad.mit.edu	37	chr12	12274335	12274335	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggggggtgcaaagtgccGgtagctatatggcctgtagc	18	7	0	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr12:12274335G>A	uc001rah.3	-	23	4709	c.4567C>T	c.(4567-4569)CGG>TGG	p.R1523W	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.R1478W	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1523	Cytoplasmic (Potential).				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GCAAAGTGCCGGTAGCTATAT	0.458													A	12274335	A	A	12274335	3	1	3	1	0	0	0	0	1	0	0	0	8962	1115	39	2	278	2	LRP6	12	12274335	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	26498	12274335	121577560	58	167											
TPTE2	93492	broad.mit.edu	37	chr13	20041405	20041405	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttaatgtcaaaaaaaatgtAaatgacatcaaccagcagag	6	7	2	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr13:20041405A>C	uc001umd.2	-	8	683	c.472T>G	c.(472-474)TAC>GAC	p.Y158D	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Intron|TPTE2_uc001ume.2_Intron|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	158	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		AAAAAAATGTAAATGACATCA	0.294													C	20041405	C	C	20041405	3	2	3	1	0	0	0	0	1	0	0	0	16428	362	13	5	1152	5	TPTE2	13	20041405	Missense_Mutation	SNP	A	TCGA-02-0047-01A-01D-1490-08		20041405	95128473	59	168											
PABPC3	5042	broad.mit.edu	37	chr13	25671552	25671552	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcaggttacttcatgacaGctgtcccacagactcagaac	7	13	3	3			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr13:25671552G>A	uc001upy.2	+	1	1277	c.1216G>A	c.(1216-1218)GCT>ACT	p.A406T		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	406					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CTTCATGACAGCTGTCCCACA	0.532													A	25671552	A	A	25671552	3	1	3	1	0	0	0	0	1	0	0	0	11365	971	34	3	1218	3	PABPC3	13	25671552	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	5630147	25671552	89498326	60	169											
C13orf23	80209	broad.mit.edu	37	chr13	39586362	39586362	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgcctgcagcttgaagtccaGatgataaactaaaacaattg	8	8	0	3			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr13:39586362G>A	uc001uwy.2	-	12	3443	c.2570C>T	c.(2569-2571)TCT>TTT	p.S857F	C13orf23_uc001uwz.2_Missense_Mutation_p.S835F	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	857										ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		TTGAAGTCCAGATGATAAACT	0.383													A	39586362	A	A	39586362	3	1	3	1	0	0	0	0	1	0	0	0	1721	942	33	3	272	3	C13orf23	13	39586362	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	13914810	39586362	75583516	61	170											
DIS3	22894	broad.mit.edu	37	chr13	73336102	73336102	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgtatattggagacgcTaagccatagtgatgaaaatc	11	5	0	3			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr13:73336102T>A	uc001vix.3	-	17	2675	c.2301A>T	c.(2299-2301)TTA>TTT	p.L767F	DIS3_uc001viy.3_Missense_Mutation_p.L737F|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	767					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TTGGAGACGCTAAGCCATAGT	0.328										Multiple Myeloma(4;0.011)			A	73336102	A	A	73336102	3	1	3	1	0	0	0	0	1	0	0	0	4535	1519	53	5	595	5	DIS3	13	73336102	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	33749740	73336102	41833776	62	171											
GPR132	29933	broad.mit.edu	37	chr14	105518226	105518226	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagctcgcagagtgccaggCagagcaggtagacggccagc	16	12	0	3			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr14:105518226C>T	uc001yqd.2	-	4	1147	c.248G>A	c.(247-249)TGC>TAC	p.C83Y	GPR132_uc001yqc.2_5'UTR|GPR132_uc001yqe.2_Missense_Mutation_p.C74Y	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	83	Helical; Name=2; (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		GAGTGCCAGGCAGAGCAGGTA	0.662													T	105518226	T	T	105518226	3	4	3	1	0	0	0	0	1	0	0	0	6642	710	25	3	898	3	GPR132	14	105518226	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08		105518226	1831314	63	172											
RYR3	6263	broad.mit.edu	37	chr15	34047281	34047281	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtaggggtatgaaggatatGgagctggatgcctcctccat	14	8	0	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr15:34047281G>A	uc001zhi.2	+	58	8485	c.8415G>A	c.(8413-8415)ATG>ATA	p.M2805I	RYR3_uc010bar.2_Missense_Mutation_p.M2805I	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2805	4.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGAAGGATATGGAGCTGGATG	0.458													A	34047281	A	A	34047281	3	1	3	1	0	0	0	0	1	0	0	0	13770	1348	47	3	8645	3	RYR3	15	34047281	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08		34047281	68484111	64	173											
BUB1B	701	broad.mit.edu	37	chr15	40512942	40512942	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggaagttaactagtcctggGgctttgctctttcagtgagc	13	8	2	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr15:40512942G>A	uc001zkx.3	+	23	3347	c.3135G>A	c.(3133-3135)GGG>GGA	p.G1045G	PAK6_uc010bbl.2_Intron|PAK6_uc010bbm.2_Intron	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	1045	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		CTAGTCCTGGGGCTTTGCTCT	0.443			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				A	40512942	A	A	40512942	2	1	3	1	0	0	0	0	0	0	0	1	1571	1219	43	3		3	BUB1B	15	40512942	Silent	SNP	G	TCGA-02-0047-01A-01D-1490-08	6465661	40512942	62018450	65	174											
ZNF280D	54816	broad.mit.edu	37	chr15	56993158	56993158	+	Frame_Shift_Del	DEL	A	-	-													gaaaaaggctgaacaataacAgaactatctgaagatctaga							TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr15:56993158delA	uc002adu.2	-	6	571	c.354delT	c.(352-354)TCTfs	p.S118fs	ZNF280D_uc002adv.2_Frame_Shift_Del_p.S105fs|ZNF280D_uc010bfq.2_Frame_Shift_Del_p.S118fs|ZNF280D_uc002adw.1_Frame_Shift_Del_p.S146fs|ZNF280D_uc010bfr.1_RNA|ZNF280D_uc002ady.2_Frame_Shift_Del_p.S118fs|ZNF280D_uc002adx.2_Frame_Shift_Del_p.S118fs	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	118					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		GAACAATAACAGAACTATCTG	0.393													-	56993158	-	-	56993158	7	5	3	1	0	1	0	1	0	0	0	0	17814	175	7	0	2749	0	ZNF280D	15	56993158	Frame_Shift_Del	DEL	A	TCGA-02-0047-01A-01D-1490-08	16480216	56993158	45538234	66	175											
ADAMTS7	11173	broad.mit.edu	37	chr15	79059831	79059831	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggcgggtggctccagggcgcTctgctcatccagccccacgc	14	17	2	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr15:79059831T>G	uc002bej.3	-	18	2960	c.2749A>C	c.(2749-2751)AGC>CGC	p.S917R	ADAMTS7_uc010und.1_Intron	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	917	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						TCCAGGGCGCTCTGCTCATCC	0.701													G	79059831	G	G	79059831	3	3	3	1	0	0	0	0	1	0	0	0	271	1551	54	5	2339	5	ADAMTS7	15	79059831	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	22066673	79059831	23471561	67	176											
C16orf91	283951	broad.mit.edu	37	chr16	1478504	1478504	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccatttcctgccgcccgCgcctttcaggacagaacaca	9	16	1	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr16:1478504C>T	uc010uvd.1	-	2	147	c.147G>A	c.(145-147)GCG>GCA	p.A49A		NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	hypothetical protein LOC283951	Error:Variant_position_missing_in_Q4G0I0_after_alignment						integral to membrane					0						CTGCCGCCCGCGCCTTTCAGG	0.677													T	1478504	T	T	1478504	2	4	3	1	0	0	0	0	0	0	0	1	1844	755	27	1		1	C16orf91	16	1478504	Silent	SNP	C	TCGA-02-0047-01A-01D-1490-08		1478504	88876249	68	177											
CREBBP	1387	broad.mit.edu	37	chr16	3843446	3843446	+	Frame_Shift_Del	DEL	C	-	-													tcaaaacgtttttcatggttCgacaatgcgggagcgagcag							TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr16:3843446delC	uc002cvv.2	-	4	1361	c.1157delG	c.(1156-1158)CGAfs	p.R386fs	CREBBP_uc002cvw.2_Frame_Shift_Del_p.R386fs	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	386	TAZ-type 1.|Interaction with SRCAP.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.R386*(1)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TTTCATGGTTCGACAATGCGG	0.507			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				-	3843446	-	-	3843446	7	5	3	1	0	1	0	1	0	0	0	0	3861	884	31	0	6283	0	CREBBP	16	3843446	Frame_Shift_Del	DEL	C	TCGA-02-0047-01A-01D-1490-08	2364942	3843446	86511307	69	178											
ABR	29	broad.mit.edu	37	chr17	953842	953842	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctttgctgacaaaatagcCgaaggaatccacctccaggg	11	11	0	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr17:953842C>T	uc002fsd.2	-	15	1704	c.1594G>A	c.(1594-1596)GGC>AGC	p.G532S	ABR_uc002fse.2_Missense_Mutation_p.G486S|ABR_uc010vqg.1_Missense_Mutation_p.G314S|ABR_uc002fsg.2_Missense_Mutation_p.G495S|ABR_uc002fsh.1_Intron	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	532	C2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		ACAAAATAGCCGAAGGAATCC	0.617													T	953842	T	T	953842	3	4	3	1	0	0	0	0	1	0	0	0	99	652	23	2	1021	2	ABR	17	953842	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08		953842	80241368	70	179											
SPACA3	124912	broad.mit.edu	37	chr17	31322643	31322643	+	Frame_Shift_Del	DEL	C	-	-													gctcagctgcctgctaccctCcagtgaggccaagctctacg							TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr17:31322643delC	uc002hhs.1	+	2	326	c.251delC	c.(250-252)TCCfs	p.S84fs	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	84	Helical; Signal-anchor for type II membrane protein; (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			CTGCTACCCTCCAGTGAGGCC	0.607													-	31322643	-	-	31322643	7	5	3	1	0	1	0	1	0	0	0	0	14973	855	30	0	257	0	SPACA3	17	31322643	Frame_Shift_Del	DEL	C	TCGA-02-0047-01A-01D-1490-08	30368801	31322643	49872567	71	180											
AMAC1	146861	broad.mit.edu	37	chr17	33521251	33521251	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggcagcgctggtaccagcGgaggctgggtggagcggagg	21	9	0	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr17:33521251G>A	uc002hjd.2	-	1	162	c.76C>T	c.(76-78)CGC>TGC	p.R26C		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	26						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		TGGTACCAGCGGAGGCTGGGT	0.657													A	33521251	A	A	33521251	3	1	3	1	0	0	0	0	1	0	0	0	559	1116	39	2	944	2	AMAC1	17	33521251	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	2198608	33521251	47673959	72	181											
GSDMA	284110	broad.mit.edu	37	chr17	38122551	38122551	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attttggctttaagaatatgCtggacacccgagtggaggga	13	6	0	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr17:38122551C>T	uc002htl.1	+	3	371	c.253C>T	c.(253-255)CTG>TTG	p.L85L	GSDMA_uc002htm.1_Silent_p.L85L	NM_178171	NP_835465	Q96QA5	GSDMA_HUMAN	gasdermin 1	85					apoptosis|induction of apoptosis	perinuclear region of cytoplasm					0						TAAGAATATGCTGGACACCCG	0.463													T	38122551	T	T	38122551	2	4	3	1	0	0	0	0	0	0	0	1	6816	796	28	3		3	GSDMA	17	38122551	Silent	SNP	C	TCGA-02-0047-01A-01D-1490-08	4601300	38122551	43072659	73	182											
KRT15	3866	broad.mit.edu	37	chr17	39673185	39673185	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgttgatgtcagcctcaaCgccctggcgcagggccagct	13	15	2	1	rs138271368		TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr17:39673185C>T	uc002hwy.2	-	3	804	c.613G>A	c.(613-615)GTT>ATT	p.V205I	KRT15_uc002hwz.2_Missense_Mutation_p.V107I|KRT15_uc002hxa.2_Missense_Mutation_p.V40I|KRT15_uc002hxb.1_Missense_Mutation_p.V40I	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	205	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				TCAGCCTCAACGCCCTGGCGC	0.612													T	39673185	T	T	39673185	3	4	3	1	0	0	0	0	1	0	0	0	8452	536	19	1	781	1	KRT15	17	39673185	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	1550634	39673185	41522025	74	183											
ARSG	22901	broad.mit.edu	37	chr17	66391258	66391258	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtagccctggcccaggccaGcttacctcaaggacggcgct	13	15	1	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr17:66391258G>A	uc002jhc.2	+	10	1932	c.1136G>A	c.(1135-1137)AGC>AAC	p.S379N	ARSG_uc002jhb.1_Missense_Mutation_p.S215N	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	379					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GCCCAGGCCAGCTTACCTCAA	0.587													A	66391258	A	A	66391258	3	1	3	1	0	0	0	0	1	0	0	0	992	971	34	3	1170	3	ARSG	17	66391258	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	26718073	66391258	14803952	75	184											
NEDD4L	23327	broad.mit.edu	37	chr18	56010160	56010160	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccaaggactcacccgtacGtcgggctgtgaaagacaccc	11	14	1	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr18:56010160G>A	uc002lgy.2	+	16	1674	c.1400G>A	c.(1399-1401)CGT>CAT	p.R467H	NEDD4L_uc002lgz.2_Missense_Mutation_p.R403H|NEDD4L_uc002lgx.2_Missense_Mutation_p.R447H|NEDD4L_uc010xee.1_Missense_Mutation_p.R346H|NEDD4L_uc002lhc.2_Missense_Mutation_p.R459H|NEDD4L_uc002lhd.2_Missense_Mutation_p.R346H|NEDD4L_uc002lhb.2_Missense_Mutation_p.R326H|NEDD4L_uc002lhe.2_Missense_Mutation_p.R439H|NEDD4L_uc002lhf.2_Missense_Mutation_p.R326H|NEDD4L_uc002lhg.2_Missense_Mutation_p.R346H|NEDD4L_uc002lhh.2_Missense_Mutation_p.R242H|NEDD4L_uc010dpm.1_Intron	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	467					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						TCACCCGTACGTCGGGCTGTG	0.488													A	56010160	A	A	56010160	3	1	3	1	0	0	0	0	1	0	0	0	10311	1145	40	1	1490	1	NEDD4L	18	56010160	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08		56010160	22067088	76	185											
HMG20B	10362	broad.mit.edu	37	chr19	3578077	3578077	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccagcacgagaagctcatcGtccgcatcaaggaaatcctg	9	14	2	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr19:3578077G>A	uc002lya.2	+	9	975	c.907G>A	c.(907-909)GTC>ATC	p.V303I	HMG20B_uc002lyb.2_Missense_Mutation_p.V201I	NM_006339	NP_006330	Q9P0W2	HM20B_HUMAN	high-mobility group 20B	303					blood coagulation|cell cycle|chromatin modification	chromosome|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGCTCATCGTCCGCATCAA	0.701													A	3578077	A	A	3578077	3	1	3	1	0	0	0	0	1	0	0	0	7222	1145	40	1	937	1	HMG20B	19	3578077	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08		3578077	55550906	77	186											
SAFB	6294	broad.mit.edu	37	chr19	5668177	5668177	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaatttgttcctaggcgcGgcagctttgccccaggcggg	15	11	0	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr19:5668177G>A	uc002mcf.2	+	21	2676	c.2623G>A	c.(2623-2625)GGC>AGC	p.G875S	SAFB_uc002mcg.2_Missense_Mutation_p.G877S|SAFB_uc002mce.3_Missense_Mutation_p.G876S|SAFB_uc010xir.1_Missense_Mutation_p.G874S|SAFB_uc010xis.1_Missense_Mutation_p.G808S|SAFB_uc010xit.1_Missense_Mutation_p.G719S|SAFB_uc010xiu.1_Missense_Mutation_p.G676S	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	875	Interaction with SAFB2.|Gly-rich.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		TCCTAGGCGCGGCAGCTTTGC	0.677													A	5668177	A	A	5668177	3	1	3	1	0	0	0	0	1	0	0	0	13806	1116	39	2	2705	2	SAFB	19	5668177	Missense_Mutation	SNP	G	TCGA-02-0047-01A-01D-1490-08	2090100	5668177	53460806	78	187											
BTBD3	22903	broad.mit.edu	37	chr20	11899075	11899075	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttgccaccagtttgttatgAaataattaccttgaagacta	7	7	0	3			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr20:11899075A>G	uc002wnz.2	+	1	511	c.152A>G	c.(151-153)GAA>GGA	p.E51G	BTBD3_uc002wny.2_5'UTR|BTBD3_uc002woa.2_5'UTR|BTBD3_uc010zrf.1_5'UTR|BTBD3_uc010zrg.1_5'Flank|BTBD3_uc010zrh.1_5'Flank	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	51										ovary(2)|central_nervous_system(1)	3						GTTTGTTATGAAATAATTACC	0.383													G	11899075	G	G	11899075	3	3	3	1	0	0	0	0	1	0	0	0	1544	246	9	4	154	4	BTBD3	20	11899075	Missense_Mutation	SNP	A	TCGA-02-0047-01A-01D-1490-08		11899075	51126445	79	188											
RPRD1B	58490	broad.mit.edu	37	chr20	36676850	36676850	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatacagcagctgaagctgTctatggaggactccaagagc	11	10	2	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr20:36676850T>C	uc002xho.3	+	3	784	c.382T>C	c.(382-384)TCT>CCT	p.S128P		NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	128	CID.									pancreas(1)	1						GCTGAAGCTGTCTATGGAGGA	0.453													C	36676850	C	C	36676850	3	2	3	1	0	0	0	0	1	0	0	0	13616	1667	58	4	392	4	RPRD1B	20	36676850	Missense_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08	24777775	36676850	26348670	80	189											
DNAJC28	54943	broad.mit.edu	37	chr21	34860697	34860697	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtatattttctgggctctgAcaatttctttctgagcatca	7	9	5	2			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr21:34860697A>G	uc002yrv.2	-	2	1453	c.1004T>C	c.(1003-1005)GTC>GCC	p.V335A	DNAJC28_uc002yrw.2_Missense_Mutation_p.V335A	NM_017833	NP_060303	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	335	Potential.			LIVPILTRQKVHFDAQKEIVRAQKIYETLIKTKEVTDRNPN NLDQGEGEKTPEIKKGFLNWMNLWKFIKIRSF -> CSHPD QAKSPF (in Ref. 2; BAA91185).			heat shock protein binding				0						CTGGGCTCTGACAATTTCTTT	0.343													G	34860697	G	G	34860697	3	3	3	1	0	0	0	0	1	0	0	0	4646	275	10	4	166	4	DNAJC28	21	34860697	Missense_Mutation	SNP	A	TCGA-02-0047-01A-01D-1490-08		34860697	13269198	81	190											
SOX10	6663	broad.mit.edu	37	chr22	38369502	38369502	+	Nonstop_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggtggcgacagggccccctTtagggccgggacagtgtcgt	17	11	0	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr22:38369502T>G	uc003aun.1	-	4	1679	c.1401A>C	c.(1399-1401)TAA>TAC	p.*467Y	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Nonstop_Mutation_p.*467Y	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	467						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)					AGGGCCCCCTTTAGGGCCGGG	0.692													G	38369502	G	G	38369502	4	3	3	1	0	0	0	0	0	0	0	0	14941	1848	64	5	3	5	SOX10	22	38369502	Nonstop_Mutation	SNP	T	TCGA-02-0047-01A-01D-1490-08		38369502	12935064	82	191											
CELSR1	9620	broad.mit.edu	37	chr22	46807508	46807508	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggatgctcacttcttggagCcggtctgagtgccctgggca	15	11	3	1			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr22:46807508C>T	uc003bhw.1	-	6	4760	c.4760G>A	c.(4759-4761)GGC>GAC	p.G1587D	CELSR1_uc011arc.1_5'Flank	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1587	Extracellular (Potential).|Laminin G-like 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CTTCTTGGAGCCGGTCTGAGT	0.632													T	46807508	T	T	46807508	3	4	3	1	0	0	0	0	1	0	0	0	3221	739	26	3	4404	3	CELSR1	22	46807508	Missense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08	8438006	46807508	4497058	83	192											
PLXNB2	23654	broad.mit.edu	37	chr22	50719359	50719359	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagcacggggatgccggcCtcgtgcacgtcgttggtctg	15	13	1	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chr22:50719359C>T	uc003bkv.3	-	24	3913	c.3807G>A	c.(3805-3807)GAG>GAA	p.E1269E	PLXNB2_uc003bkt.1_Silent_p.E61E|PLXNB2_uc003bku.1_Silent_p.E254E	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1269	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGATGCCGGCCTCGTGCACGT	0.652													T	50719359	T	T	50719359	2	4	3	1	0	0	0	0	0	0	0	1	12124	680	24	3		3	PLXNB2	22	50719359	Silent	SNP	C	TCGA-02-0047-01A-01D-1490-08	3911851	50719359	585207	84	193											
USP9X	8239	broad.mit.edu	37	chrX	41075440	41075440	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtgtgctcgtacacagtggtCaagcgagtggggggcattat	16	7	1	0			TCGA-02-0047-01A-01D-1490-08	TCGA-02-0047-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce03026e-b756-43a2-972d-b3a4dcda5491	12cccbae-0ffc-43ee-8aa5-7ec47611b497	g.chrX:41075440C>T	uc004dfb.2	+	35	6253	c.5620C>T	c.(5620-5622)CAA>TAA	p.Q1874*	USP9X_uc004dfc.2_Nonsense_Mutation_p.Q1874*	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1874					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						ACACAGTGGTCAAGCGAGTGG	0.443													T	41075440	T	T	41075440	4	4	3	1	0	0	0	0	0	1	0	0	17087	827	29	3	5754	3	USP9X	23	41075440	Nonsense_Mutation	SNP	C	TCGA-02-0047-01A-01D-1490-08		41075440	114195120	85	194											
GJB3	2707	broad.mit.edu	37	chr1	35250842	35250842	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatggcttcaatatgccgcGcctggtgcagtgtgccaacg	13	12	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:35250842G>A	uc001bxx.2	+	2	1094	c.479G>A	c.(478-480)CGC>CAC	p.R160H	GJB3_uc001bxy.2_Missense_Mutation_p.R160H|GJB3_uc001bxz.3_Missense_Mutation_p.R160H|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	160	Extracellular (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				AATATGCCGCGCCTGGTGCAG	0.552													A	35250842	A	A	35250842	3	1	4	1	0	0	0	0	1	0	0	0	6409	1087	38	1	481	1	GJB3	1	35250842	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08		35250842	213999779	1	195											
C8B	732	broad.mit.edu	37	chr1	57395177	57395177	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttgtcttgtcttacgtcttCcagagcatgaagaccaattt	7	9	3	3			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:57395177C>T	uc001cyp.2	-	12	1743	c.1676G>A	c.(1675-1677)GGA>GAA	p.G559E	C8B_uc010oon.1_Missense_Mutation_p.G497E|C8B_uc010ooo.1_Missense_Mutation_p.G507E	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	559	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						CTTACGTCTTCCAGAGCATGA	0.448													T	57395177	T	T	57395177	3	4	4	1	0	0	0	0	1	0	0	0	2417	855	30	3	103	3	C8B	1	57395177	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08	22144335	57395177	191855444	2	196											
HOOK1	51361	broad.mit.edu	37	chr1	60294482	60294482	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggtttaacgaatcttggttAagccgaattaaagaggatgt	11	4	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:60294482A>T	uc009wad.2	+	4	282	c.180A>T	c.(178-180)TTA>TTT	p.L60F	HOOK1_uc001czo.2_Missense_Mutation_p.L60F|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Missense_Mutation_p.L18F	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	60	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					AATCTTGGTTAAGCCGAATTA	0.348													T	60294482	T	T	60294482	3	4	4	1	0	0	0	0	1	0	0	0	7282	359	13	5	190	5	HOOK1	1	60294482	Missense_Mutation	SNP	A	TCGA-02-0055-01A-01D-1490-08	2899305	60294482	188956139	3	197											
COL11A1	1301	broad.mit.edu	37	chr1	103453212	103453212	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttctcctgcttgacctgaagGacctgggtctccagttgggc	12	12	2	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:103453212G>A	uc001dul.2	-	30	2797	c.2479C>T	c.(2479-2481)CCT>TCT	p.P827S	COL11A1_uc001duk.2_Silent_p.V17V|COL11A1_uc001dum.2_Missense_Mutation_p.P839S|COL11A1_uc001dun.2_Missense_Mutation_p.P788S|COL11A1_uc009weh.2_Missense_Mutation_p.P711S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	827	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.P839S(1)		ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGACCTGAAGGACCTGGGTCT	0.453													A	103453212	A	A	103453212	3	1	4	1	0	0	0	0	1	0	0	0	3667	1174	41	3	3093	3	COL11A1	1	103453212	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	43158730	103453212	145797409	4	198											
PYHIN1	149628	broad.mit.edu	37	chr1	158912123	158912123	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agaagagcaaagaaaattccGaagatcaatattcttcacaa	6	7	3	4			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:158912123G>A	uc001ftb.2	+	5	1181	c.936G>A	c.(934-936)CCG>CCA	p.P312P	PYHIN1_uc001ftc.2_Silent_p.P303P|PYHIN1_uc001ftd.2_Silent_p.P312P|PYHIN1_uc001fte.2_Silent_p.P303P	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	312	HIN-200.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					AGAAAATTCCGAAGATCAATA	0.378													A	158912123	A	A	158912123	2	1	4	1	0	0	0	0	0	0	0	1	12865	1045	37	2		2	PYHIN1	1	158912123	Silent	SNP	G	TCGA-02-0055-01A-01D-1490-08	55458911	158912123	90338498	5	199											
RASAL2	9462	broad.mit.edu	37	chr1	178425898	178425898	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ctctccctcgtgttcttgctGatattaccaagtcattgact	6	12	3	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:178425898G>T	uc001glr.2	+	11	1956	c.1831G>T	c.(1831-1833)GAT>TAT	p.D611Y	RASAL2_uc001glq.2_Missense_Mutation_p.D752Y|RASAL2_uc009wxc.2_Missense_Mutation_p.D125Y	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	611					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						TGTTCTTGCTGATATTACCAA	0.468													T	178425898	T	T	178425898	3	4	4	1	0	0	0	0	1	0	0	0	13064	1290	45	5	2342	5	RASAL2	1	178425898	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	19513775	178425898	70824723	6	200											
STX6	10228	broad.mit.edu	37	chr1	180971810	180971810	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcagttgcatcaaggttaaAttttctaggatttgcttcaa	7	6	4	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:180971810A>G	uc010pnq.1	-	3	469	c.232T>C	c.(232-234)TTT>CTT	p.F78L	STX6_uc001goo.2_Missense_Mutation_p.F78L|STX6_uc010pnr.1_Intron	NM_005819	NP_005810	O43752	STX6_HUMAN	syntaxin 6	78	Cytoplasmic (Potential).				Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			ovary(1)	1						TCAAGGTTAAATTTTCTAGGA	0.353													G	180971810	G	G	180971810	3	3	4	1	0	0	0	0	1	0	0	0	15348	101	4	4	559	4	STX6	1	180971810	Missense_Mutation	SNP	A	TCGA-02-0055-01A-01D-1490-08	2545912	180971810	68278811	7	201											
CENPF	1063	broad.mit.edu	37	chr1	214787153	214787153	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcctacaagagctcttcagaAaattcaagagcttgaaggac	9	9	3	4			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:214787153A>G	uc001hkm.2	+	2	230	c.56A>G	c.(55-57)AAA>AGA	p.K19R		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	19	Interaction with SNAP25 and required for localization to the cytoplasm (By similarity).|Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding	p.K19R(1)		ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GCTCTTCAGAAAATTCAAGAG	0.428													G	214787153	G	G	214787153	3	3	4	1	0	0	0	0	1	0	0	0	3231	14	1	4	58	4	CENPF	1	214787153	Missense_Mutation	SNP	A	TCGA-02-0055-01A-01D-1490-08	33815343	214787153	34463468	8	202											
OBSCN	84033	broad.mit.edu	37	chr1	228504460	228504460	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaacgcggcggtccgggccGgcgcacaggcatgcttcacc	14	15	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:228504460G>A	uc009xez.1	+	51	13380	c.13336G>A	c.(13336-13338)GGC>AGC	p.G4446S	OBSCN_uc001hsn.2_Missense_Mutation_p.G4446S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4446	Ig-like 46.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGTCCGGGCCGGCGCACAGGC	0.672													A	228504460	A	A	228504460	3	1	4	1	0	0	0	0	1	0	0	0	10812	1116	39	2	13534	2	OBSCN	1	228504460	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	13717307	228504460	20746161	9	203											
OR2L13	284521	broad.mit.edu	37	chr1	248263034	248263034	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctgacctccatggcctaCgaccgttatttggccatctg	8	15	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr1:248263034C>T	uc001ids.2	+	3	694	c.357C>T	c.(355-357)TAC>TAT	p.Y119Y		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CCATGGCCTACGACCGTTATT	0.512													T	248263034	T	T	248263034	2	4	4	1	0	0	0	0	0	0	0	1	11006	547	19	1		1	OR2L13	1	248263034	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08	19758574	248263034	987587	10	204											
IL1RN	3557	broad.mit.edu	37	chr2	113890330	113890330	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caccaccagttttgagtctgCcgcctgccccggttggttcc	10	16	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr2:113890330C>A	uc002tjb.2	+	4	480	c.416C>A	c.(415-417)GCC>GAC	p.A139D	IL1RN_uc002tix.1_RNA|IL1RN_uc002tiy.2_Missense_Mutation_p.A105D|IL1RN_uc002tiz.2_Missense_Mutation_p.A142D|IL1RN_uc002tja.2_Missense_Mutation_p.A121D	NM_173842	NP_776214	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist isoform 1	139					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			skin(2)	2					Anakinra(DB00026)	TTTGAGTCTGCCGCCTGCCCC	0.572									Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				A	113890330	A	A	113890330	3	1	4	1	0	0	0	0	1	0	0	0	7665	739	26	5	511	5	IL1RN	2	113890330	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08		113890330	129309043	11	205											
PPIG	9360	broad.mit.edu	37	chr2	170494029	170494029	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	aacagatgaagacaaaagcgGatgagtgagttatataaact	10	4	0	5			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr2:170494029G>C	uc002uez.2	+	14	2481	c.2261G>C	c.(2260-2262)GGA>GCA	p.G754A	PPIG_uc010fpx.2_Missense_Mutation_p.G739A|PPIG_uc010fpy.2_Missense_Mutation_p.G747A|PPIG_uc002ufb.2_Missense_Mutation_p.G754A|PPIG_uc002ufd.2_Missense_Mutation_p.G751A	NM_004792	NP_004783	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G	754					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)	GACAAAAGCGGATGAGTGAGT	0.313													C	170494029	C	C	170494029	3	2	4	1	0	0	0	0	1	0	0	0	12324	1174	41	5	2307	5	PPIG	2	170494029	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	56603699	170494029	72705344	12	206											
TTN	7273	broad.mit.edu	37	chr2	179412263	179412263	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gactttaatttgagtgcgctTgacactggaattgacaagct	10	7	0	3			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr2:179412263T>C	uc010zfg.1	-	288	86610	c.86386A>G	c.(86386-86388)AAG>GAG	p.K28796E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K22491E|TTN_uc010zfi.1_Missense_Mutation_p.K22424E|TTN_uc010zfj.1_Missense_Mutation_p.K22299E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29723							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGTGCGCTTGACACTGGAA	0.413													C	179412263	C	C	179412263	3	2	4	1	0	0	0	0	1	0	0	0	16732	1821	63	4	13985	4	TTN	2	179412263	Missense_Mutation	SNP	T	TCGA-02-0055-01A-01D-1490-08	8918234	179412263	63787110	13	207											
COL6A3	1293	broad.mit.edu	37	chr2	238275663	238275663	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttacccgcaggtgctcaaGgcccaccttagtgttggcgt	12	12	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr2:238275663G>A	uc002vwl.2	-	11	5452	c.5167C>T	c.(5167-5169)CTT>TTT	p.L1723F	COL6A3_uc002vwo.2_Missense_Mutation_p.L1517F|COL6A3_uc010znj.1_Missense_Mutation_p.L1116F	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1723	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGGTGCTCAAGGCCCACCTTA	0.547													A	238275663	A	A	238275663	3	1	4	1	0	0	0	0	1	0	0	0	3701	1000	35	3	4502	3	COL6A3	2	238275663	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	58863400	238275663	4923710	14	208											
ITPR1	3708	broad.mit.edu	37	chr3	4816936	4816936	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaattgcagaacttcctccGttgccaaaataacaagacca	5	13	0	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr3:4816936G>A	uc003bqa.2	+	44	6194	c.5846G>A	c.(5845-5847)CGT>CAT	p.R1949H	ITPR1_uc010hca.1_Missense_Mutation_p.R1934H|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.R919H	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1997	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AACTTCCTCCGTTGCCAAAAT	0.483													A	4816936	A	A	4816936	3	1	4	1	0	0	0	0	1	0	0	0	7920	1145	40	1	6168	1	ITPR1	3	4816936	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08		4816936	193205494	15	209											
FGD5	152273	broad.mit.edu	37	chr3	14905722	14905722	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgaagagcagagaagctcGgaggaggaggacagtgcttc	17	6	0	3			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr3:14905722G>A	uc003bzc.2	+	2	2723	c.2613G>A	c.(2611-2613)TCG>TCA	p.S871S	FGD5_uc011avk.1_Silent_p.S871S	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	871					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						AGAGAAGCTCGGAGGAGGAGG	0.597													A	14905722	A	A	14905722	2	1	4	1	0	0	0	0	0	0	0	1	5836	1103	39	2		2	FGD5	3	14905722	Silent	SNP	G	TCGA-02-0055-01A-01D-1490-08	10088786	14905722	183116708	16	210											
CTBP1	1487	broad.mit.edu	37	chr4	1209830	1209830	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggttgtgctcgttgaggccGcagtgcagggtcacgcagtc	16	10	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr4:1209830G>A	uc003gcv.1	-	5	876	c.711C>T	c.(709-711)TGC>TGT	p.C237C	uc003gcs.1_RNA|CTBP1_uc003gct.1_Silent_p.C218C|CTBP1_uc003gcu.1_Silent_p.C226C|CTBP1_uc003gcw.2_5'Flank	NM_001328	NP_001319	Q13363	CTBP1_HUMAN	C-terminal binding protein 1 isoform 1	237	NAD (By similarity).				interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		CGTTGAGGCCGCAGTGCAGGG	0.637													A	1209830	A	A	1209830	2	1	4	1	0	0	0	0	0	0	0	1	3997	1079	38	1		1	CTBP1	4	1209830	Silent	SNP	G	TCGA-02-0055-01A-01D-1490-08		1209830	189944446	17	211											
HGFAC	3083	broad.mit.edu	37	chr4	3449235	3449235	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagcccccccagggacagcGtctccgtggtgctgggccag	14	16	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr4:3449235G>A	uc003ghc.2	+	11	1375	c.1372G>A	c.(1372-1374)GTC>ATC	p.V458I	HGFAC_uc010icw.2_Missense_Mutation_p.V465I	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	458	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CAGGGACAGCGTCTCCGTGGT	0.667													A	3449235	A	A	3449235	3	1	4	1	0	0	0	0	1	0	0	0	7086	1145	40	1	1414	1	HGFAC	4	3449235	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	2239405	3449235	187705041	18	212											
ADRA2C	152	broad.mit.edu	37	chr4	3769412	3769412	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgagttcttcctgtcgcgccGgcgccgggcgcgcagcagcg	16	16	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr4:3769412G>A	uc003ghm.2	+	1	1117	c.1079G>A	c.(1078-1080)CGG>CAG	p.R360Q	ADRA2C_uc010icx.2_Intron	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	360	Cytoplasmic (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CTGTCGCGCCGGCGCCGGGCG	0.726													A	3769412	A	A	3769412	3	1	4	1	0	0	0	0	1	0	0	0	339	1116	39	2	1081	2	ADRA2C	4	3769412	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	320177	3769412	187384864	19	213											
AFM	173	broad.mit.edu	37	chr4	74354406	74354406	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atttaaggagcttatttctcTtgtagaagatgtttcttcca	7	6	2	2	rs139224995	byFrequency	TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr4:74354406T>C	uc003hhb.2	+	7	804	c.773T>C	c.(772-774)CTT>CCT	p.L258P		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	258	Albumin 2.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTTATTTCTCTTGTAGAAGAT	0.353													C	74354406	C	C	74354406	3	2	4	1	0	0	0	0	1	0	0	0	361	1609	56	4	799	4	AFM	4	74354406	Missense_Mutation	SNP	T	TCGA-02-0055-01A-01D-1490-08	70584994	74354406	116799870	20	214											
FAT4	79633	broad.mit.edu	37	chr4	126373451	126373451	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgaagagaacaatagaacGtttcttttggcagctgtgaa	10	5	1	4			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr4:126373451G>A	uc003ifj.3	+	9	11280	c.11280G>A	c.(11278-11280)ACG>ACA	p.T3760T	FAT4_uc011cgp.1_Silent_p.T2058T|FAT4_uc003ifi.1_Silent_p.T1238T	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3760	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACAATAGAACGTTTCTTTTGG	0.453													A	126373451	A	A	126373451	2	1	4	1	0	0	0	0	0	0	0	1	5692	1132	40	1		1	FAT4	4	126373451	Silent	SNP	G	TCGA-02-0055-01A-01D-1490-08	52019045	126373451	64780825	21	215											
ENPP6	133121	broad.mit.edu	37	chr4	185074883	185074883	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgatggacttcacaatggCggcctatgtcaatgagaaca	10	9	3	2	rs142786439		TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr4:185074883C>T	uc003iwc.2	-	2	387	c.245G>A	c.(244-246)CGC>CAC	p.R82H		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	82	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		TTCACAATGGCGGCCTATGTC	0.453													T	185074883	T	T	185074883	3	4	4	1	0	0	0	0	1	0	0	0	5134	768	27	1	1105	1	ENPP6	4	185074883	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08	58701432	185074883	6079393	22	216											
PLEKHG4B	153478	broad.mit.edu	37	chr5	163558	163558	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccacagagaagaagctccCgctgtggcagcatgccagga	13	12	0	2	rs148435989		TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr5:163558C>T	uc003jak.2	+	11	2353	c.2303C>T	c.(2302-2304)CCG>CTG	p.P768L		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	768					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AAGAAGCTCCCGCTGTGGCAG	0.652													T	163558	T	T	163558	3	4	4	1	0	0	0	0	1	0	0	0	12072	652	23	2	2345	2	PLEKHG4B	5	163558	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08		163558	180751702	23	217											
IPO11	51194	broad.mit.edu	37	chr5	61887491	61887491	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaagatcctgaaacaggaacTtataaagagtaggtgcatta	10	5	0	3			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr5:61887491T>A	uc003jtc.2	+	28	2860	c.2670T>A	c.(2668-2670)ACT>ACA	p.T890T	IPO11_uc011cqr.1_Silent_p.T930T|IPO11_uc010iwr.2_Silent_p.T155T|IPO11_uc003jte.2_Silent_p.T9T	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	890						cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		AAACAGGAACTTATAAAGAGT	0.338													A	61887491	A	A	61887491	2	1	4	1	0	0	0	0	0	0	0	1	7793	1596	56	5		5	IPO11	5	61887491	Silent	SNP	T	TCGA-02-0055-01A-01D-1490-08	61723933	61887491	119027769	24	218											
SLC27A6	28965	broad.mit.edu	37	chr5	128301930	128301930	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgggatgacttctggttcGtgttgaaggtggtgctcatt	14	5	2	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr5:128301930G>A	uc003kuy.2	+	2	496	c.100G>A	c.(100-102)GTG>ATG	p.V34M	SLC27A6_uc003kuz.2_Missense_Mutation_p.V34M	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	34	Helical; (Potential).				long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CTTCTGGTTCGTGTTGAAGGT	0.463													A	128301930	A	A	128301930	3	1	4	1	0	0	0	0	1	0	0	0	14530	1145	40	1	102	1	SLC27A6	5	128301930	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	66414439	128301930	52613330	25	219											
PCDHGA1	56114	broad.mit.edu	37	chr5	140712400	140712400	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgctggcgcacaggctgCggcgctggcacaagtcacgt	15	13	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr5:140712400C>T	uc003lji.1	+	1	2149	c.2149C>T	c.(2149-2151)CGG>TGG	p.R717W	PCDHGA1_uc011dan.1_Missense_Mutation_p.R717W	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	717	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACAGGCTGCGGCGCTGGCA	0.657													T	140712400	T	T	140712400	3	4	4	1	0	0	0	0	1	0	0	0	11550	759	27	1	2151	1	PCDHGA1	5	140712400	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08	12410470	140712400	40202860	26	220											
FAM153C	653316	broad.mit.edu	37	chr5	177466410	177466410	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccttgggagttccacaacGtggtacgtattggggaaccc	12	10	0	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr5:177466410G>A	uc011dge.1	+	6	332	c.131G>A	c.(130-132)CGT>CAT	p.R44H	FAM153C_uc003mig.1_Missense_Mutation_p.R44H	NM_001079527	NP_001072995			hypothetical protein LOC653316												0	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTCCACAACGTGGTACGTAT	0.478													A	177466410	A	A	177466410	3	1	4	1	0	0	0	0	1	0	0	0	5462	1145	40	1	145	1	FAM153C	5	177466410	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	36754010	177466410	3448850	27	221											
ZC3H12D	340152	broad.mit.edu	37	chr6	149795611	149795611	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccctcgcccagcttgcccaaCacccggagcacatcctcccg	7	22	0	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr6:149795611C>A	uc003qmn.1	-	1	139	c.69G>T	c.(67-69)GTG>GTT	p.V23V	PPIL4_uc010kic.2_Intron|ZC3H12D_uc003qmm.2_Silent_p.V23V|ZC3H12D_uc010kid.2_Silent_p.V23V	NM_207360	NP_997243	A2A288	ZC12D_HUMAN	zinc finger CCCH-type containing 12D	23						cytoplasm|nucleus	endonuclease activity|nucleic acid binding|zinc ion binding				0		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.23e-11)|GBM - Glioblastoma multiforme(68;0.0921)		GCTTGCCCAACACCCGGAGCA	0.677													A	149795611	A	A	149795611	2	1	4	1	0	0	0	0	0	0	0	1	17561	465	17	5		5	ZC3H12D	6	149795611	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08		149795611	21319456	28	222											
CYCS	54205	broad.mit.edu	37	chr7	25163649	25163649	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagagaccatggagatttggCccagtcttgtgcttgcctcc	11	11	1	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr7:25163649C>T	uc003sxl.2	-	2	235	c.90G>A	c.(88-90)GGG>GGA	p.G30G		NM_018947	NP_061820	P99999	CYC_HUMAN	cytochrome c	30					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis by intracellular signals|respiratory electron transport chain|transport	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleus|protein phosphatase type 2A complex|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding|protein binding			ovary(1)|lung(1)	2					Melatonin(DB01065)|Minocycline(DB01017)	GGAGATTTGGCCCAGTCTTGT	0.443													T	25163649	T	T	25163649	2	4	4	1	0	0	0	0	0	0	0	1	4136	726	26	3		3	CYCS	7	25163649	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08		25163649	133975014	29	223											
JHDM1D	80853	broad.mit.edu	37	chr7	139824534	139824534	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaactccaagattcataaCgtgccaaattttcatctgtt	5	9	3	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr7:139824534C>T	uc003vvm.2	-	7	942	c.938G>A	c.(937-939)CGT>CAT	p.R313H		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	313	JmjC.				midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					AGATTCATAACGTGCCAAATT	0.358													T	139824534	T	T	139824534	3	4	4	1	0	0	0	0	1	0	0	0	7948	536	19	1	1943	1	JHDM1D	7	139824534	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08	114660885	139824534	19314129	30	224											
OR2A2	442361	broad.mit.edu	37	chr7	143807248	143807248	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagctggcctgtgctgacacCtgggttaaccaagtggtcat	12	10	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr7:143807248C>T	uc011ktz.1	+	1	573	c.573C>T	c.(571-573)ACC>ACT	p.T191T		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					GTGCTGACACCTGGGTTAACC	0.512													T	143807248	T	T	143807248	2	4	4	1	0	0	0	0	0	0	0	1	10977	668	24	3		3	OR2A2	7	143807248	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08	3982714	143807248	15331415	31	225											
PLAG1	5324	broad.mit.edu	37	chr8	57079222	57079222	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcacgccaccttgtaactcCatcaggtaactctcaatttc	6	14	2	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr8:57079222C>T	uc003xsq.3	-	3	1534	c.1083G>A	c.(1081-1083)ATG>ATA	p.M361I	PLAG1_uc003xsr.3_Missense_Mutation_p.M361I|PLAG1_uc010lyi.2_Missense_Mutation_p.M361I|PLAG1_uc010lyj.2_Missense_Mutation_p.M279I	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	361	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.M361I(1)	CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			CTTGTAACTCCATCAGGTAAC	0.438			T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								T	57079222	T	T	57079222	3	4	4	1	0	0	0	0	1	0	0	0	12018	594	21	3	423	3	PLAG1	8	57079222	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08		57079222	89284800	32	226											
MATN2	4147	broad.mit.edu	37	chr8	99044505	99044505	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccgatggaagacaggactcTccagcaggggaactgccaaa	12	11	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr8:99044505T>C	uc003yic.2	+	16	2772	c.2541T>C	c.(2539-2541)TCT>TCC	p.S847S	MATN2_uc010mbh.1_Silent_p.S806S|MATN2_uc003yid.2_Silent_p.S847S|MATN2_uc003yie.1_Silent_p.S847S|MATN2_uc010mbi.1_Silent_p.S680S|MATN2_uc010mbj.1_Silent_p.S208S|RPL30_uc010mbk.1_Intron	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	847						proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GACAGGACTCTCCAGCAGGGG	0.473													C	99044505	C	C	99044505	2	2	4	1	0	0	0	0	0	0	0	1	9334	1538	54	4		4	MATN2	8	99044505	Silent	SNP	T	TCGA-02-0055-01A-01D-1490-08	41965283	99044505	47319517	33	227											
C10orf18	54906	broad.mit.edu	37	chr10	5791482	5791482	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccatttctgcatcctgcacCtaggagcagaagcccccttc	7	17	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr10:5791482C>T	uc001iij.2	+	15	6723	c.6098C>T	c.(6097-6099)CCT>CTT	p.P2033L	C10orf18_uc001iik.2_Missense_Mutation_p.P877L	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2033										ovary(1)|central_nervous_system(1)	2						CATCCTGCACCTAGGAGCAGA	0.547													T	5791482	T	T	5791482	3	4	4	1	0	0	0	0	1	0	0	0	1596	681	24	3	6144	3	C10orf18	10	5791482	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08		5791482	129743265	34	228											
ARMC3	219681	broad.mit.edu	37	chr10	23250972	23250972	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caatgctaagagacaatcaaGgattggaccatcttattaag	8	7	2	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr10:23250972G>A	uc001irm.3	+	7	780	c.697G>A	c.(697-699)GGA>AGA	p.G233R	ARMC3_uc010qcv.1_Missense_Mutation_p.G233R|ARMC3_uc010qcw.1_Intron	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	233	ARM 6.						binding				0						AGACAATCAAGGATTGGACCA	0.358													A	23250972	A	A	23250972	3	1	4	1	0	0	0	0	1	0	0	0	952	1001	35	3	719	3	ARMC3	10	23250972	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	17459490	23250972	112283775	35	229											
ZNF248	57209	broad.mit.edu	37	chr10	38126948	38126948	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctataattttccaggatcAcatctctgtatagaatcttc	5	9	3	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr10:38126948A>G	uc001izd.1	-	4	606	c.107T>C	c.(106-108)GTG>GCG	p.V36A	ZNF248_uc009xmc.2_Missense_Mutation_p.V36A|ZNF248_uc001izb.2_RNA|ZNF248_uc001izc.2_Missense_Mutation_p.V36A|ZNF248_uc010qeu.1_Missense_Mutation_p.V36A	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	36	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCCAGGATCACATCTCTGTA	0.413													G	38126948	G	G	38126948	3	3	4	1	0	0	0	0	1	0	0	0	17790	159	6	4	1644	4	ZNF248	10	38126948	Missense_Mutation	SNP	A	TCGA-02-0055-01A-01D-1490-08	14875976	38126948	97407799	36	230											
PTEN	5728	broad.mit.edu	37	chr10	89692907	89692907	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtaaagctggaaagggacgaActggtgtaatgatatgtgca	14	4	0	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr10:89692907A>G	uc001kfb.2	+	6	1422	c.391A>G	c.(391-393)ACT>GCT	p.T131A		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	131	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.T131fs*3(3)|p.?(2)|p.Y27fs*1(2)|p.K128_R130del(2)|p.Y27_N212>Y(2)|p.T131A(1)|p.K128fs*47(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.T131N(1)|p.T131fs*50(1)|p.T131P(1)|p.T131fs*42(1)|p.T131I(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AAAGGGACGAACTGGTGTAAT	0.398		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			G	89692907	G	G	89692907	3	3	4	1	0	0	0	0	1	0	0	0	12738	43	2	4	409	4	PTEN	10	89692907	Missense_Mutation	SNP	A	TCGA-02-0055-01A-01D-1490-08	51565959	89692907	45841840	37	231											
PHRF1	57661	broad.mit.edu	37	chr11	608380	608380	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggaagccccacccagcccggAcgtgctgcaggctgccaccc	12	19	0	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr11:608380A>T	uc001lqe.2	+	14	3055	c.2924A>T	c.(2923-2925)GAC>GTC	p.D975V	PHRF1_uc010qwc.1_Missense_Mutation_p.D974V|PHRF1_uc010qwd.1_Missense_Mutation_p.D973V|PHRF1_uc010qwe.1_Missense_Mutation_p.D971V|PHRF1_uc009ybz.1_Missense_Mutation_p.D765V|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	975							RNA polymerase binding|zinc ion binding				0						CCCAGCCCGGACGTGCTGCAG	0.657													T	608380	T	T	608380	3	4	4	1	0	0	0	0	1	0	0	0	11861	275	10	5	2971	5	PHRF1	11	608380	Missense_Mutation	SNP	A	TCGA-02-0055-01A-01D-1490-08		608380	134398136	38	232											
OR51D1	390038	broad.mit.edu	37	chr11	4661587	4661587	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaacacatactgtcacacaCtccttctgtctgcaccaaga	4	15	3	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr11:4661587C>T	uc010qyk.1	+	1	567	c.567C>T	c.(565-567)CAC>CAT	p.H189H		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTCACACACTCCTTCTGTC	0.483													T	4661587	T	T	4661587	2	4	4	1	0	0	0	0	0	0	0	1	11093	564	20	3		3	OR51D1	11	4661587	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08	4053207	4661587	130344929	39	233											
PICALM	8301	broad.mit.edu	37	chr11	85733503	85733503	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	accgcctaataaatgtagacAtgtcatatcctgtaaaaaaa	5	8	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr11:85733503A>T	uc001pbm.2	-	4	645	c.359T>A	c.(358-360)ATG>AAG	p.M120K	PICALM_uc001pbl.2_Missense_Mutation_p.M120K|PICALM_uc001pbn.2_Missense_Mutation_p.M120K|PICALM_uc010rtl.1_Missense_Mutation_p.M69K	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	120	ENTH.				clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				AAATGTAGACATGTCATATCC	0.289			T	MLLT10|MLL	TALL|AML|								T	85733503	T	T	85733503	3	4	4	1	0	0	0	0	1	0	0	0	11880	217	8	5	1695	5	PICALM	11	85733503	Missense_Mutation	SNP	A	TCGA-02-0055-01A-01D-1490-08	81071916	85733503	49273013	40	234											
ANO2	57101	broad.mit.edu	37	chr12	5842030	5842030	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttatcacactgaaaaccaaAcctgggcacgttcctgggga	10	11	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr12:5842030A>G	uc001qnm.2	-	14	1506	c.1434_splice	c.e14+1	p.Q478_splice		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2							chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						TGAAAACCAAACCTGGGCACG	0.483													G	5842030	G	G	5842030	5	3	4	1	0	0	0	0	0	0	1	0	697	57	2	4	1612	4	ANO2	12	5842030	Splice_Site	SNP	A	TCGA-02-0055-01A-01D-1490-08		5842030	128009865	41	235											
LEPREL2	10536	broad.mit.edu	37	chr12	6946911	6946911	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctaggagagcaagagcagcGcatggacctgagtcacccag	13	12	1	3			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr12:6946911G>A	uc001qra.1	+	14	1761	c.1727G>A	c.(1726-1728)CGC>CAC	p.R576H	LEPREL2_uc001qqz.1_Missense_Mutation_p.R383H|LEPREL2_uc001qrb.1_Missense_Mutation_p.R383H|GNB3_uc001qrc.2_5'Flank|GNB3_uc001qrd.2_5'Flank	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	576	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CAAGAGCAGCGCATGGACCTG	0.652													A	6946911	A	A	6946911	3	1	4	1	0	0	0	0	1	0	0	0	8731	1087	38	1	1772	1	LEPREL2	12	6946911	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	1104881	6946911	126904984	42	236											
NOS1	4842	broad.mit.edu	37	chr12	117768967	117768967	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatccaggcttcaggctacaCggagagcaggagccggggtg	17	10	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr12:117768967C>T	uc001twm.1	-	2	594	c.-92G>A	c.(-94--90)CCGTG>CCATG			NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal						multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCAGGCTACACGGAGAGCAGG	0.582													T	117768967	T	T	117768967	1	4	4	1	0	0	0	0	0	0	0	0	10541	551	19	1		1	NOS1	12	117768967	Translation_Start_Site	SNP	C	TCGA-02-0055-01A-01D-1490-08	110822056	117768967	16082928	43	237											
UBC	7316	broad.mit.edu	37	chr12	125397201	125397201	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acctctgagacggagcaccaGgtgcaaggtggactctttct	12	11	3	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr12:125397201G>T	uc001ugs.3	-	2	1565	c.1117C>A	c.(1117-1119)CTG>ATG	p.L373M	UBC_uc001ugr.2_Intron|UBC_uc001ugu.1_Missense_Mutation_p.L373M|UBC_uc001ugt.2_Missense_Mutation_p.L373M|UBC_uc001ugv.2_Intron	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	373	Ubiquitin-like 5.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CGGAGCACCAGGTGCAAGGTG	0.532													T	125397201	T	T	125397201	3	4	4	1	0	0	0	0	1	0	0	0	16839	991	35	5	944	5	UBC	12	125397201	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	7628234	125397201	8454694	44	238											
OCA2	4948	broad.mit.edu	37	chr15	28202861	28202861	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgagcagtcaggcgccagaCgtgaatctcgtgcttcagtt	12	11	3	3			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr15:28202861C>G	uc001zbh.3	-	16	1767	c.1657G>C	c.(1657-1659)GTC>CTC	p.V553L	OCA2_uc010ayv.2_Missense_Mutation_p.V529L	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	553	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AGGCGCCAGACGTGAATCTCG	0.617									Oculocutaneous_Albinism				G	28202861	G	G	28202861	3	3	4	1	0	0	0	0	1	0	0	0	10815	536	19	5	895	5	OCA2	15	28202861	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08		28202861	74328531	45	239											
TRPM1	4308	broad.mit.edu	37	chr15	31342763	31342763	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtggctttgctgtccgtcGggggtgccaggcttcccagg	16	13	0	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr15:31342763G>A	uc001zfm.2	-	11	1348	c.1220C>T	c.(1219-1221)CCG>CTG	p.P407L	TRPM1_uc010azy.2_Missense_Mutation_p.P314L|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	407	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GCTGTCCGTCGGGGGTGCCAG	0.453													A	31342763	A	A	31342763	3	1	4	1	0	0	0	0	1	0	0	0	16582	1116	39	2	3659	2	TRPM1	15	31342763	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	3139902	31342763	71188629	46	240											
EXD1	161829	broad.mit.edu	37	chr15	41483752	41483752	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtttggaagatagccacccGtttccatggaaaactgaagt	10	8	0	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr15:41483752G>A	uc001znk.2	-	8	769	c.578C>T	c.(577-579)ACG>ATG	p.T193M	EXD1_uc001znj.2_5'Flank|EXD1_uc010ucv.1_Missense_Mutation_p.T251M	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	193					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						ATAGCCACCCGTTTCCATGGA	0.383													A	41483752	A	A	41483752	3	1	4	1	0	0	0	0	1	0	0	0	5297	1145	40	1	978	1	EXD1	15	41483752	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	10140989	41483752	61047640	47	241											
SPG11	80208	broad.mit.edu	37	chr15	44876437	44876437	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgggctctgtttcctcctgaTttcttccaagagtgtgctgg	11	10	2	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr15:44876437T>C	uc001ztx.2	-	30	5472	c.5441A>G	c.(5440-5442)AAT>AGT	p.N1814S	SPG11_uc010bdw.2_Missense_Mutation_p.N103S|SPG11_uc010ueh.1_Missense_Mutation_p.N1814S|SPG11_uc010uei.1_Missense_Mutation_p.N1814S|SPG11_uc001zty.1_Missense_Mutation_p.N543S	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1814	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TTCCTCCTGATTTCTTCCAAG	0.512													C	44876437	C	C	44876437	3	2	4	1	0	0	0	0	1	0	0	0	15040	1493	52	4	1934	4	SPG11	15	44876437	Missense_Mutation	SNP	T	TCGA-02-0055-01A-01D-1490-08	3392685	44876437	57654955	48	242											
SEMA6D	80031	broad.mit.edu	37	chr15	48056239	48056239	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggcatccccactgtggtcGgggtgtttaccacgcagctc	12	13	0	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr15:48056239G>A	uc010bek.2	+	10	1300	c.940G>A	c.(940-942)GGG>AGG	p.G314R	SEMA6D_uc001zvw.2_Missense_Mutation_p.G314R|SEMA6D_uc001zvx.1_Missense_Mutation_p.G314R|SEMA6D_uc001zvy.2_Missense_Mutation_p.G314R|SEMA6D_uc001zvz.2_Missense_Mutation_p.G314R|SEMA6D_uc001zwa.2_Missense_Mutation_p.G314R|SEMA6D_uc001zwb.2_Missense_Mutation_p.G314R|SEMA6D_uc001zwc.2_Missense_Mutation_p.G314R	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	314	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CACTGTGGTCGGGGTGTTTAC	0.483													A	48056239	A	A	48056239	3	1	4	1	0	0	0	0	1	0	0	0	14042	1116	39	2	974	2	SEMA6D	15	48056239	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	3179802	48056239	54475153	49	243											
ALDH1A2	8854	broad.mit.edu	37	chr15	58253017	58253017	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccccaaaggggctctgggCatttaaggcattgtaacaat	10	10	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr15:58253017C>T	uc002aex.2	-	12	1493	c.1435G>A	c.(1435-1437)GCC>ACC	p.A479T	ALDH1A2_uc002aey.2_Missense_Mutation_p.A441T|ALDH1A2_uc010ugv.1_Missense_Mutation_p.A458T|ALDH1A2_uc010ugw.1_Missense_Mutation_p.A450T|ALDH1A2_uc002aew.2_Missense_Mutation_p.A383T	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	479					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GGGCTCTGGGCATTTAAGGCA	0.408													T	58253017	T	T	58253017	3	4	4	1	0	0	0	0	1	0	0	0	491	710	25	3	129	3	ALDH1A2	15	58253017	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08	10196778	58253017	44278375	50	244											
CLDN6	9074	broad.mit.edu	37	chr16	3065604	3065604	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtcccggatgatggcatgcGccgtccagcacacggggatt	14	12	0	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr16:3065604G>A	uc002csu.3	-	2	479	c.419C>T	c.(418-420)GCG>GTG	p.A140V		NM_021195	NP_067018	P56747	CLD6_HUMAN	claudin 6	140	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GATGGCATGCGCCGTCCAGCA	0.622													A	3065604	A	A	3065604	3	1	4	1	0	0	0	0	1	0	0	0	3489	1087	38	1	247	1	CLDN6	16	3065604	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08		3065604	87289149	51	245											
SCNN1B	6338	broad.mit.edu	37	chr16	23360038	23360038	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaacacccacggccccaagCgcatcatctgtgaggggccc	10	18	2	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr16:23360038C>T	uc002dln.2	+	2	294	c.118C>T	c.(118-120)CGC>TGC	p.R40C		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	40	Cytoplasmic (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CGGCCCCAAGCGCATCATCTG	0.622													T	23360038	T	T	23360038	3	4	4	1	0	0	0	0	1	0	0	0	13928	768	27	1	120	1	SCNN1B	16	23360038	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08	20294434	23360038	66994715	52	246											
ITGAD	3681	broad.mit.edu	37	chr16	31422517	31422517	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgagggggccaggtgtccGtgtgtcccttgcctaggggg	18	12	0	0	rs147338780		TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr16:31422517G>A	uc002ebv.1	+	13	1526	c.1477G>A	c.(1477-1479)GTG>ATG	p.V493M	ITGAD_uc010cap.1_Missense_Mutation_p.V493M	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	493	Extracellular (Potential).|FG-GAP 5.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CCAGGTGTCCGTGTGTCCCTT	0.632													A	31422517	A	A	31422517	3	1	4	1	0	0	0	0	1	0	0	0	7884	1145	40	1	1527	1	ITGAD	16	31422517	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	8062479	31422517	58932236	53	247											
WDR59	79726	broad.mit.edu	37	chr16	74976699	74976699	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggcagttagcattttttttAttccatttgacctgggaggc	10	7	0	1	rs11394861		TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr16:74976699A>T	uc002fdh.1	-	7	573	c.471T>A	c.(469-471)AAT>AAA	p.N157K	WDR59_uc002fdi.2_Missense_Mutation_p.N157K|WDR59_uc002fdj.2_Missense_Mutation_p.N157K	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	157	WD 3.									ovary(1)|breast(1)	2						CATTTTTTTTATTCCATTTGA	0.502													T	74976699	T	T	74976699	3	4	4	1	0	0	0	0	1	0	0	0	17305	446	16	5	2533	5	WDR59	16	74976699	Missense_Mutation	SNP	A	TCGA-02-0055-01A-01D-1490-08	43554182	74976699	15378054	54	248											
KCNG4	93107	broad.mit.edu	37	chr16	84270708	84270708	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaagcaccagcttcccggcCgccaggaagctcacgatcac	10	16	2	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr16:84270708C>T	uc010voc.1	-	2	505	c.384G>A	c.(382-384)GCG>GCA	p.A128A	KCNG4_uc002fhu.1_Silent_p.A128A	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	128	Helical; Name=Segment S1; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						GCTTCCCGGCCGCCAGGAAGC	0.637													T	84270708	T	T	84270708	2	4	4	1	0	0	0	0	0	0	0	1	8030	639	23	2		2	KCNG4	16	84270708	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08	9294009	84270708	6084045	55	249											
TP53	7157	broad.mit.edu	37	chr17	7578203	7578203	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggctcatagggcaccaccaCactatgtcgaaaagtgtttc	9	12	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr17:7578203C>T	uc002gim.2	-	6	840	c.646G>A	c.(646-648)GTG>ATG	p.V216M	TP53_uc002gig.1_Missense_Mutation_p.V216M|TP53_uc002gih.2_Missense_Mutation_p.V216M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V84M|TP53_uc010cng.1_Missense_Mutation_p.V84M|TP53_uc002gii.1_Missense_Mutation_p.V84M|TP53_uc010cnh.1_Missense_Mutation_p.V216M|TP53_uc010cni.1_Missense_Mutation_p.V216M|TP53_uc002gij.2_Missense_Mutation_p.V216M|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.V123M|TP53_uc002gio.2_Missense_Mutation_p.V84M|TP53_uc010vug.1_Missense_Mutation_p.V177M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	216	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> A (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V216M(49)|p.V216del(8)|p.0?(7)|p.V216L(7)|p.V216E(4)|p.V216G(3)|p.V216A(3)|p.V216fs*6(2)|p.V216fs*31(2)|p.H214fs*5(2)|p.K164_P219del(1)|p.V216fs*32(1)|p.V216fs*33(1)|p.S215fs*27(1)|p.S215fs*29(1)|p.V216fs*5(1)|p.V216_Y220delVVVPY(1)|p.D208_V216delDRNTFRHSV(1)|p.D208fs*1(1)|p.V216fs*28(1)|p.S215fs*31(1)|p.S215_V216insX(1)|p.T211fs*28(1)|p.D207_V216del10(1)|p.S215_V218>R(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACCACCACACTATGTCGA	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578203	T	T	7578203	3	4	4	1	0	0	0	0	1	0	0	0	16378	478	17	3	648	3	TP53	17	7578203	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08		7578203	73617007	56	250											
MGAT5B	146664	broad.mit.edu	37	chr17	74936837	74936837	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcccagcatccctacgcGgagaacttcatcggcaagcc	8	16	2	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr17:74936837G>A	uc002jti.2	+	13	1885	c.1782G>A	c.(1780-1782)GCG>GCA	p.A594A	MGAT5B_uc002jth.2_Silent_p.A583A	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	585	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						ATCCCTACGCGGAGAACTTCA	0.552													A	74936837	A	A	74936837	2	1	4	1	0	0	0	0	0	0	0	1	9549	1103	39	2		2	MGAT5B	17	74936837	Silent	SNP	G	TCGA-02-0055-01A-01D-1490-08	67358634	74936837	6258373	57	251											
PAPL	390928	broad.mit.edu	37	chr19	39597641	39597641	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccgaggccctggagtgccGtgcgtgtgaaggagtacggg	18	10	0	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr19:39597641G>A	uc002oki.2	+	12	1442	c.1168G>A	c.(1168-1170)GTG>ATG	p.V390M	PAPL_uc010egl.2_Intron	NM_001004318	NP_001004318	Q6ZNF0	PAPL_HUMAN	iron/zinc purple acid phosphatase-like protein	390						extracellular region	acid phosphatase activity|metal ion binding				0						CTGGAGTGCCGTGCGTGTGAA	0.652													A	39597641	A	A	39597641	3	1	4	1	0	0	0	0	1	0	0	0	11427	1145	40	1	1210	1	PAPL	19	39597641	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08		39597641	19531342	58	252											
PSG1	5669	broad.mit.edu	37	chr19	43376198	43376198	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggagggcttaggagtctccaCtgtgcagaaaacagggtgaa	15	7	1	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr19:43376198C>A	uc002ovb.2	-	3	569	c.431_splice	c.e3-1	p.L144_splice	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Splice_Site_p.L144_splice|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Splice_Site|PSG1_uc002our.1_Splice_Site_p.L144_splice|PSG1_uc010eio.1_Splice_Site_p.L144_splice|PSG1_uc002oux.1_Splice_Site_p.L73_splice|PSG1_uc002ouy.1_Splice_Site_p.L144_splice|PSG1_uc002ouz.1_Splice_Site_p.L144_splice|PSG1_uc002ova.1_Intron|PSG1_uc002ovc.2_Intron|PSG1_uc002ovd.1_Splice_Site_p.L144_splice	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1						female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GGAGTCTCCACTGTGCAGAAA	0.527													A	43376198	A	A	43376198	5	1	4	1	0	0	0	0	0	0	1	0	12653	579	20	5	898	5	PSG1	19	43376198	Splice_Site	SNP	C	TCGA-02-0055-01A-01D-1490-08	3778557	43376198	15752785	59	253											
BTBD3	22903	broad.mit.edu	37	chr20	11900455	11900455	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gaaatccgtataccagatgtCgaacctgctgcttttctcgc	8	12	1	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr20:11900455C>G	uc002wnz.2	+	3	866	c.507C>G	c.(505-507)GTC>GTG	p.V169V	BTBD3_uc002wny.2_Silent_p.V108V|BTBD3_uc002woa.2_Silent_p.V108V|BTBD3_uc010zrf.1_Silent_p.V18V|BTBD3_uc010zrg.1_Silent_p.V18V|BTBD3_uc010zrh.1_Silent_p.V18V	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	169	BTB.									ovary(2)|central_nervous_system(1)	3						TACCAGATGTCGAACCTGCTG	0.418													G	11900455	G	G	11900455	2	3	4	1	0	0	0	0	0	0	0	1	1544	871	31	5		5	BTBD3	20	11900455	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08		11900455	51125065	60	254											
DEFB118	117285	broad.mit.edu	37	chr20	29960755	29960755	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aagatacatgcaaaaatcttCgagcttgctgcattccatcc	6	11	1	1	rs34328728		TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr20:29960755C>T	uc002wvr.2	+	2	180	c.154C>T	c.(154-156)CGA>TGA	p.R52*		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	52					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CAAAAATCTTCGAGCTTGCTG	0.438													T	29960755	T	T	29960755	4	4	4	1	0	0	0	0	0	1	0	0	4406	876	31	2	160	2	DEFB118	20	29960755	Nonsense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08	18060300	29960755	33064765	61	255											
ASXL1	171023	broad.mit.edu	37	chr20	31022345	31022345	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgccggggttggactggCgccaggaccctcgcagacat	14	14	0	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr20:31022345C>T	uc002wxs.2	+	12	2256	c.1830C>T	c.(1828-1830)GGC>GGT	p.G610G	ASXL1_uc010geb.2_Silent_p.G501G	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	610					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.Q592fs*5(1)|p.G610G(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GTTGGACTGGCGCCAGGACCC	0.632			F|N|Mis		MDS|CMML								T	31022345	T	T	31022345	2	4	4	1	0	0	0	0	0	0	0	1	1066	755	27	1		1	ASXL1	20	31022345	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08	1061590	31022345	32003175	62	256											
DLGAP4	22839	broad.mit.edu	37	chr20	35075140	35075140	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaccagtatgaggcggcctGcgagtcagcctgcagtgaag	15	10	1	3			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr20:35075140G>A	uc002xff.2	+	7	1883	c.1448G>A	c.(1447-1449)TGC>TAC	p.C483Y	DLGAP4_uc010zvp.1_Missense_Mutation_p.C483Y	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	483					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GAGGCGGCCTGCGAGTCAGCC	0.647													A	35075140	A	A	35075140	3	1	4	1	0	0	0	0	1	0	0	0	4562	1319	46	3	1466	3	DLGAP4	20	35075140	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	4052795	35075140	27950380	63	257											
KRTAP19-3	337970	broad.mit.edu	37	chr21	31864264	31864264	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcctccatagtagctgccGtagtagctcatggtgtcagg	13	10	2	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr21:31864264G>A	uc002yog.1	-	1	12	c.12C>T	c.(10-12)TAC>TAT	p.Y4Y		NM_181609	NP_853640	Q7Z4W3	KR193_HUMAN	keratin associated protein 19-3	4						intermediate filament					0						AGTAGCTGCCGTAGTAGCTCA	0.547													A	31864264	A	A	31864264	2	1	4	1	0	0	0	0	0	0	0	1	8530	1140	40	1		1	KRTAP19-3	21	31864264	Silent	SNP	G	TCGA-02-0055-01A-01D-1490-08		31864264	16265631	64	258											
TPST2	8459	broad.mit.edu	37	chr22	26937269	26937269	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agacttggaccaggcctggcGcatggccagcacgcgcggga	16	13	0	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chr22:26937269G>A	uc003acv.2	-	2	496	c.328C>T	c.(328-330)CGC>TGC	p.R110C	TPST2_uc003acw.2_Missense_Mutation_p.R110C|TPST2_uc003acx.2_Missense_Mutation_p.R110C|TPST2_uc011akf.1_Missense_Mutation_p.R110C	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	110	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						CAGGCCTGGCGCATGGCCAGC	0.697													A	26937269	A	A	26937269	3	1	4	1	0	0	0	0	1	0	0	0	16425	1087	38	1	821	1	TPST2	22	26937269	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08		26937269	24367297	65	259											
P2RY8	286530	broad.mit.edu	37	chrX	1584470	1584470	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgcacggacgtggtcctggCggagaagaggctctcgcggc	18	12	1	2			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:1584470C>T	uc004cpz.2	-	2	1230	c.982G>A	c.(982-984)GCC>ACC	p.A328T		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	328	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTGGTCCTGGCGGAGAAGAGG	0.682			T	CRLF2	B-ALL|Downs associated ALL								T	1584470	T	T	1584470	3	4	4	1	0	0	0	0	1	0	0	0	11355	768	27	1	101	1	P2RY8	23	1584470	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08		1584470	153686090	66	260											
GEMIN8	54960	broad.mit.edu	37	chrX	14027285	14027285	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcatccagctgctgctgcCgccctgagaacaaacacgaa	9	15	0	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:14027285C>T	uc004cwb.2	-	5	819	c.476G>A	c.(475-477)CGG>CAG	p.R159Q	GEMIN8_uc004cwc.2_Missense_Mutation_p.R159Q|GEMIN8_uc004cwd.2_Missense_Mutation_p.R159Q	NM_017856	NP_060326	Q9NWZ8	GEMI8_HUMAN	gem (nuclear organelle) associated protein 8	159	Potential.				spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding				0						CTGCTGCTGCCGCCCTGAGAA	0.582													T	14027285	T	T	14027285	3	4	4	1	0	0	0	0	1	0	0	0	6334	652	23	2	256	2	GEMIN8	23	14027285	Missense_Mutation	SNP	C	TCGA-02-0055-01A-01D-1490-08	12442815	14027285	141243275	67	261											
KLHL34	257240	broad.mit.edu	37	chrX	21674666	21674666	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcaccagaagtgggcccgcGcttcccgcatggcgggcact	14	16	0	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:21674666G>A	uc004czz.1	-	1	1783	c.1241C>T	c.(1240-1242)GCG>GTG	p.A414V		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	414	Kelch 2.									ovary(1)	1						GTGGGCCCGCGCTTCCCGCAT	0.721													A	21674666	A	A	21674666	3	1	4	1	0	0	0	0	1	0	0	0	8387	1087	38	1	697	1	KLHL34	23	21674666	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	7647381	21674666	133595894	68	262											
USP11	8237	broad.mit.edu	37	chrX	47102906	47102906	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactacaacaactcctactaCggcctgatgctttttggaca	7	12	0	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:47102906C>T	uc004dhp.2	+	13	1824	c.1824C>T	c.(1822-1824)TAC>TAT	p.Y608Y	USP11_uc004dhq.2_Silent_p.Y335Y	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	608					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						ACTCCTACTACGGCCTGATGC	0.592													T	47102906	T	T	47102906	2	4	4	1	0	0	0	0	0	0	0	1	17039	547	19	1		1	USP11	23	47102906	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08	25428240	47102906	108167654	69	263											
ZNF81	347344	broad.mit.edu	37	chrX	47775654	47775654	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatgtgggaaggccttcaccGacaggtcaaatttcaataaa	9	8	3	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:47775654G>A	uc010nhy.1	+	6	1977	c.1609G>A	c.(1609-1611)GAC>AAC	p.D537N		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	537	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				GGCCTTCACCGACAGGTCAAA	0.443													A	47775654	A	A	47775654	3	1	4	1	0	0	0	0	1	0	0	0	18171	1058	37	2	1623	2	ZNF81	23	47775654	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	672748	47775654	107494906	70	264											
ERCC6L	54821	broad.mit.edu	37	chrX	71424939	71424939	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgcactttttatgtcaagCgctttaactaagcagtttag	7	8	2	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:71424939C>T	uc004eaq.1	-	2	3775	c.3678G>A	c.(3676-3678)GCG>GCA	p.A1226A	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Silent_p.A1103A	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	1226	TPR 2.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					TTATGTCAAGCGCTTTAACTA	0.363													T	71424939	T	T	71424939	2	4	4	1	0	0	0	0	0	0	0	1	5218	755	27	1		1	ERCC6L	23	71424939	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08	23649285	71424939	83845621	71	265											
TBX22	50945	broad.mit.edu	37	chrX	79286010	79286010	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcacaggtggaagcagtggCtcatctccagtgacctctag	11	11	4	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:79286010C>T	uc010nmg.1	+	9	1097	c.963C>T	c.(961-963)GGC>GGT	p.G321G	TBX22_uc004edi.1_Silent_p.G201G|TBX22_uc004edj.1_Silent_p.G321G	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	321					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						GAAGCAGTGGCTCATCTCCAG	0.433													T	79286010	T	T	79286010	2	4	4	1	0	0	0	0	0	0	0	1	15655	784	28	3		3	TBX22	23	79286010	Silent	SNP	C	TCGA-02-0055-01A-01D-1490-08	7861071	79286010	75984550	72	266											
H2BFWT	158983	broad.mit.edu	37	chrX	103267902	103267902	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gatgcggtccaatatgtcatGaaccaaagaatccatgacac	8	10	1	3			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:103267902G>A	uc004elr.2	-	1	355	c.331C>T	c.(331-333)CAT>TAT	p.H111Y		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	111					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						AATATGTCATGAACCAAAGAA	0.637													A	103267902	A	A	103267902	3	1	4	1	0	0	0	0	1	0	0	0	6932	1290	45	3	204	3	H2BFWT	23	103267902	Missense_Mutation	SNP	G	TCGA-02-0055-01A-01D-1490-08	23981892	103267902	52002658	73	267											
FAM70A	55026	broad.mit.edu	37	chrX	119394752	119394752	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgtaaggtggtggcttttcAaaaggtggatagtagggtgg	17	3	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:119394752A>G	uc004eso.3	-	10	1250	c.1023T>C	c.(1021-1023)TTT>TTC	p.F341F	FAM70A_uc004esp.3_Silent_p.F317F|FAM70A_uc010nqo.2_Silent_p.F233F	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	341	Pro-rich.					integral to membrane				lung(1)|breast(1)	2						GTGGCTTTTCAAAAGGTGGAT	0.507													G	119394752	G	G	119394752	2	3	4	1	0	0	0	0	0	0	0	1	5605	127	5	4		4	FAM70A	23	119394752	Silent	SNP	A	TCGA-02-0055-01A-01D-1490-08	16126850	119394752	35875808	74	268											
F9	2158	broad.mit.edu	37	chrX	138623341	138623341	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggatttgaaggaaagaactgTgaattaggtaagtaactatt	11	2	0	3			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:138623341T>G	uc004fas.1	+	4	413	c.384T>G	c.(382-384)TGT>TGG	p.C128W	F9_uc004fat.1_Intron	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	128	EGF-like 1; calcium-binding (Potential).				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GAAAGAACTGTGAATTAGGTA	0.348													G	138623341	G	G	138623341	3	3	4	1	0	0	0	0	1	0	0	0	5351	1702	59	5	398	5	F9	23	138623341	Missense_Mutation	SNP	T	TCGA-02-0055-01A-01D-1490-08	19228589	138623341	16647219	75	269											
GABRA3	2556	broad.mit.edu	37	chrX	151336828	151336828	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttgtcaaccttgctgacacTgttgtaggtcttggtctcag	10	9	3	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:151336828T>A	uc010ntk.1	-	10	1591	c.1351A>T	c.(1351-1353)AGT>TGT	p.S451C		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	451	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTGCTGACACTGTTGTAGGTC	0.527													A	151336828	A	A	151336828	3	1	4	1	0	0	0	0	1	0	0	0	6162	1580	55	5	131	5	GABRA3	23	151336828	Missense_Mutation	SNP	T	TCGA-02-0055-01A-01D-1490-08	12713487	151336828	3933732	76	270											
CTAG2	30848	broad.mit.edu	37	chrX	153880614	153880614	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctccctgggctccctcgggTggcggcgggcctggtgtacc	16	15	1	0			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:153880614T>C	uc004fmi.1	-	2	614	c.561A>G	c.(559-561)CCA>CCG	p.P187P	CTAG2_uc004fmh.1_Intron	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	187	Poly-Pro.					centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTCCCTCGGGTGGCGGCGGGC	0.602													C	153880614	C	C	153880614	2	2	4	1	0	0	0	0	0	0	0	1	3991	1683	59	4		4	CTAG2	23	153880614	Silent	SNP	T	TCGA-02-0055-01A-01D-1490-08	2543786	153880614	1389946	77	271											
F8	2157	broad.mit.edu	37	chrX	154156957	154156957	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctgcgggggctctgatttTcatcctcatcataaatgtca	9	10	5	1			TCGA-02-0055-01A-01D-1490-08	TCGA-02-0055-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cd89af4-5118-4adb-aa1d-fbd03bf42a33	b1a5f80a-e21a-4d8c-9a2b-b7a3c47c28b7	g.chrX:154156957T>G	uc004fmt.2	-	14	5279	c.5108A>C	c.(5107-5109)GAA>GCA	p.E1703A		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1703					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GCTCTGATTTTCATCCTCATC	0.408													G	154156957	G	G	154156957	3	3	4	1	0	0	0	0	1	0	0	0	5350	1783	62	5	2027	5	F8	23	154156957	Missense_Mutation	SNP	T	TCGA-02-0055-01A-01D-1490-08	276343	154156957	1113603	78	272											
NKAIN1	79570	broad.mit.edu	37	chr1	31658176	31658176	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcaccagccaggctgcatacTggggaaagcagaggtgggat	16	9	0	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr1:31658176T>C	uc010ogd.1	-	3	199	c.193_splice	c.e3-1	p.Y65_splice	NKAIN1_uc001bsn.2_Splice_Site_p.Y21_splice|NKAIN1_uc010ogc.1_Intron	NM_024522	NP_078798	Q4KMZ8	NKAI1_HUMAN	Na+/K+ transporting ATPase interacting 1							integral to membrane|plasma membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|Breast(348;0.141)|all_neural(195;0.146)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0184)|READ - Rectum adenocarcinoma(331;0.148)		GGCTGCATACTGGGGAAAGCA	0.587													C	31658176	C	C	31658176	5	2	5	1	0	0	0	0	0	0	1	0	10435	1594	55	4	452	4	NKAIN1	1	31658176	Splice_Site	SNP	T	TCGA-02-2470-01A-01D-1494-08		31658176	217592445	1	273											
KCNA2	3737	broad.mit.edu	37	chr1	111146955	111146955	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctgggtattcaaagagaagCcacacttgtctctgaaactc	8	10	3	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr1:111146955C>A	uc001dzu.2	-	2	946	c.450G>T	c.(448-450)TGG>TGT	p.W150C	KCNA2_uc009wfv.1_Missense_Mutation_p.W150C|KCNA2_uc009wfw.2_Missense_Mutation_p.W150C	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	150						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CAAAGAGAAGCCACACTTGTC	0.473													A	111146955	A	A	111146955	3	1	5	1	0	0	0	0	1	0	0	0	8003	740	26	5	1053	5	KCNA2	1	111146955	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	79488779	111146955	138103666	2	274											
RYR2	6262	broad.mit.edu	37	chr1	237604722	237604722	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acaacatgtagacacaggccTatggcttacttaccagtctg	8	11	1	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr1:237604722T>A	uc001hyl.1	+	13	1229	c.1109T>A	c.(1108-1110)CTA>CAA	p.L370Q		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	370	Cytoplasmic (By similarity).|MIR 5.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GACACAGGCCTATGGCTTACT	0.373													A	237604722	A	A	237604722	3	1	5	1	0	0	0	0	1	0	0	0	13769	1522	53	5	1159	5	RYR2	1	237604722	Missense_Mutation	SNP	T	TCGA-02-2470-01A-01D-1494-08	126457767	237604722	11645899	3	275											
TPO	7173	broad.mit.edu	37	chr2	1488428	1488428	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgaggccttccagcagtacGtgggtccctatgaaggctat	12	12	0	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr2:1488428G>A	uc002qww.2	+	9	1490	c.1399G>A	c.(1399-1401)GTG>ATG	p.V467M	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.V467M|TPO_uc002qwr.2_Missense_Mutation_p.V467M|TPO_uc002qwx.2_Missense_Mutation_p.V467M|TPO_uc010yio.1_Missense_Mutation_p.V294M|TPO_uc010yip.1_Missense_Mutation_p.V467M|TPO_uc002qwy.1_Translation_Start_Site|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	467	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CCAGCAGTACGTGGGTCCCTA	0.587													A	1488428	A	A	1488428	3	1	5	1	0	0	0	0	1	0	0	0	16407	1145	40	1	1429	1	TPO	2	1488428	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08		1488428	241710945	4	276											
EMILIN1	11117	broad.mit.edu	37	chr2	27303034	27303034	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacaggaactggtgtgcctaCgtggtgacccggacagtgag	15	9	0	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr2:27303034C>T	uc002rii.3	+	2	614	c.186C>T	c.(184-186)TAC>TAT	p.Y62Y	EMILIN1_uc010eyq.1_Silent_p.Y62Y	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	62	EMI.				cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGTGCCTACGTGGTGACCC	0.592													T	27303034	T	T	27303034	2	4	5	1	0	0	0	0	0	0	0	1	5093	547	19	1		1	EMILIN1	2	27303034	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08	25814606	27303034	215896339	5	277											
PSME4	23198	broad.mit.edu	37	chr2	54094006	54094006	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctagcaccccagcatggcGtttgaccaactctgcaaaga	8	14	1	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr2:54094006G>A	uc002rxp.2	-	45	5331	c.5275C>T	c.(5275-5277)CGC>TGC	p.R1759C	PSME4_uc010yop.1_Missense_Mutation_p.R1649C|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Missense_Mutation_p.R1134C|PSME4_uc010fbv.1_Missense_Mutation_p.R903C|PSME4_uc010fbt.1_Missense_Mutation_p.R194C	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1759					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CCAGCATGGCGTTTGACCAAC	0.418													A	54094006	A	A	54094006	3	1	5	1	0	0	0	0	1	0	0	0	12709	1145	40	1	264	1	PSME4	2	54094006	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	26790972	54094006	189105367	6	278											
IL1R2	7850	broad.mit.edu	37	chr2	102638708	102638708	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcaagaccatatcagcttctCtgggtaaggcccacaaggac	9	12	3	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr2:102638708C>T	uc002tbm.2	+	6	977	c.748C>T	c.(748-750)CTG>TTG	p.L250L	IL1R2_uc002tbn.2_Silent_p.L250L|IL1R2_uc002tbo.1_Silent_p.L250L	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	250	Extracellular (Potential).|Ig-like C2-type 3.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	ATCAGCTTCTCTGGGTAAGGC	0.507													T	102638708	T	T	102638708	2	4	5	1	0	0	0	0	0	0	0	1	7659	912	32	3		3	IL1R2	2	102638708	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08	48544702	102638708	140560665	7	279											
SLC5A7	60482	broad.mit.edu	37	chr2	108609520	108609520	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atggaaaacgcatgggcggaCtcctgtttattcctgcactg	11	10	0	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr2:108609520C>A	uc002tdv.2	+	4	661	c.385C>A	c.(385-387)CTC>ATC	p.L129I	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.L129I|SLC5A7_uc010ywn.1_Missense_Mutation_p.L16I	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	129	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity	p.L129L(1)		ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CATGGGCGGACTCCTGTTTAT	0.453													A	108609520	A	A	108609520	3	1	5	1	0	0	0	0	1	0	0	0	14670	565	20	5	395	5	SLC5A7	2	108609520	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	5970812	108609520	134589853	8	280											
STAM2	10254	broad.mit.edu	37	chr2	153003822	153003822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcacatactttaggatgtgCcttttaaggaaaaggaaagg	10	5	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr2:153003822C>T	uc002tyc.3	-	5	651	c.301G>A	c.(301-303)GCA>ACA	p.A101T	STAM2_uc010foa.1_Missense_Mutation_p.A101T|STAM2_uc002tyd.2_Missense_Mutation_p.A101T	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	101	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		TTAGGATGTGCCTTTTAAGGA	0.299													T	153003822	T	T	153003822	3	4	5	1	0	0	0	0	1	0	0	0	15248	753	26	3	1316	3	STAM2	2	153003822	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	44394302	153003822	90195551	9	281											
NHEJ1	79840	broad.mit.edu	37	chr2	220012493	220012493	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgccagactcatgcccatcaGaggacgaatcaaatgttggg	11	10	3	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr2:220012493G>A	uc002vjp.3	-	4	561	c.415C>T	c.(415-417)CTG>TTG	p.L139L	NHEJ1_uc002vjq.3_RNA	NM_024782	NP_079058	Q9H9Q4	NHEJ1_HUMAN	nonhomologous end-joining factor 1	139					B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			lung(1)	1		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		ATGCCCATCAGAGGACGAATC	0.433								Direct_reversal_of_damage|NHEJ					A	220012493	A	A	220012493	2	1	5	1	0	0	0	0	0	0	0	1	10402	933	33	3		3	NHEJ1	2	220012493	Silent	SNP	G	TCGA-02-2470-01A-01D-1494-08	67008671	220012493	23186880	10	282											
XYLB	9942	broad.mit.edu	37	chr3	38411555	38411555	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttccttcctcaggttctggaAtgaatttgttgcagatacag	9	8	2	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr3:38411555A>G	uc003cic.2	+	9	764	c.655A>G	c.(655-657)ATG>GTG	p.M219V	XYLB_uc011ayp.1_Missense_Mutation_p.M82V|XYLB_uc003cid.1_Missense_Mutation_p.M141V	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	219					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		AGGTTCTGGAATGAATTTGTT	0.443													G	38411555	G	G	38411555	3	3	5	1	0	0	0	0	1	0	0	0	17459	101	4	4	689	4	XYLB	3	38411555	Missense_Mutation	SNP	A	TCGA-02-2470-01A-01D-1494-08		38411555	159610875	11	283											
CD96	10225	broad.mit.edu	37	chr3	111264248	111264248	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaccttctcattcagacacaCggtaagcataactggtagag	8	10	2	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr3:111264248C>T	uc003dxw.2	+	2	587	c.417C>T	c.(415-417)CAC>CAT	p.H139H	CD96_uc003dxv.2_Silent_p.H139H|CD96_uc003dxx.2_Silent_p.H139H|CD96_uc010hpy.1_Silent_p.H139H	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	139	Extracellular (Potential).				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						TTCAGACACACGGTAAGCATA	0.418									Opitz_Trigonocephaly_syndrome				T	111264248	T	T	111264248	2	4	5	1	0	0	0	0	0	0	0	1	3048	550	19	1		1	CD96	3	111264248	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08	72852693	111264248	86758182	12	284											
DOK7	285489	broad.mit.edu	37	chr4	3478126	3478126	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gttggagagcggcccggctaCcctgcacctctgcaatgatg	13	13	1	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr4:3478126C>A	uc003ghd.2	+	4	459	c.389C>A	c.(388-390)ACC>AAC	p.T130N	DOK7_uc003ghe.2_5'UTR	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	130	IRS-type PTB.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GGCCCGGCTACCCTGCACCTC	0.512													A	3478126	A	A	3478126	3	1	5	1	0	0	0	0	1	0	0	0	4702	507	18	5	403	5	DOK7	4	3478126	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08		3478126	187676150	13	285											
GABRA4	2557	broad.mit.edu	37	chr4	46967126	46967126	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagcaaactcgataagggccGaaaatacaaaagcaaagcag	9	9	0	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr4:46967126G>A	uc003gxg.2	-	8	1134	c.995C>T	c.(994-996)TCG>TTG	p.S332L		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	332	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GATAAGGGCCGAAAATACAAA	0.458													A	46967126	A	A	46967126	3	1	5	1	0	0	0	0	1	0	0	0	6163	1059	37	2	677	2	GABRA4	4	46967126	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	43489000	46967126	144187150	14	286											
NUP54	53371	broad.mit.edu	37	chr4	77065621	77065621	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgttgtcccaaatcctccaaAcccacctaattaaaaaagaa	3	12	0	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr4:77065621A>G	uc003hjs.2	-	2	201	c.73T>C	c.(73-75)TTT>CTT	p.F25L	NUP54_uc010ije.2_5'UTR|NUP54_uc011cbs.1_5'UTR|NUP54_uc011cbt.1_Missense_Mutation_p.F25L|NUP54_uc003hjt.2_5'UTR	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	25	Gly-rich.|2.|9 X 2 AA repeats of F-G.			AGGF -> GWV (in Ref. 1; AAF67488).	carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2						AATCCTCCAAACCCACCTAAT	0.333													G	77065621	G	G	77065621	3	3	5	1	0	0	0	0	1	0	0	0	10767	43	2	4	1494	4	NUP54	4	77065621	Missense_Mutation	SNP	A	TCGA-02-2470-01A-01D-1494-08	30098495	77065621	114088655	15	287											
ARHGAP24	83478	broad.mit.edu	37	chr4	86916597	86916597	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccctgttttggatgggccccCgcaggacgacctttcccacc	10	17	0	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr4:86916597C>A	uc003hpk.2	+	9	2239	c.1790C>A	c.(1789-1791)CCG>CAG	p.P597Q	ARHGAP24_uc003hpl.2_Missense_Mutation_p.P502Q|ARHGAP24_uc010ikf.2_Missense_Mutation_p.P512Q|ARHGAP24_uc003hpm.2_Missense_Mutation_p.P504Q	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	597					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		GATGGGCCCCCGCAGGACGAC	0.557													A	86916597	A	A	86916597	3	1	5	1	0	0	0	0	1	0	0	0	873	652	23	5	1936	5	ARHGAP24	4	86916597	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	9850976	86916597	104237679	16	288											
PDHA2	5161	broad.mit.edu	37	chr4	96761886	96761886	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgactttatatggggatggCgctgcgaatcaggggcagat	15	6	1	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr4:96761886C>T	uc003htr.3	+	1	648	c.585C>T	c.(583-585)GGC>GGT	p.G195G		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	195					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	ATGGGGATGGCGCTGCGAATC	0.473													T	96761886	T	T	96761886	2	4	5	1	0	0	0	0	0	0	0	1	11665	755	27	1		1	PDHA2	4	96761886	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08	9845289	96761886	94392390	17	289											
ADH7	131	broad.mit.edu	37	chr4	100349053	100349053	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatccaccactgtgtactcGgtaaatgtactggtgttcat	8	10	2	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr4:100349053G>A	uc003huv.1	-	5	576	c.477C>T	c.(475-477)ACC>ACT	p.T159T		NM_000673	NP_000664	P40394	ADH7_HUMAN	class IV alcohol dehydrogenase, mu or sigma	159					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			lung(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	CTGTGTACTCGGTAAATGTAC	0.458													A	100349053	A	A	100349053	2	1	5	1	0	0	0	0	0	0	0	1	313	1103	39	2		2	ADH7	4	100349053	Silent	SNP	G	TCGA-02-2470-01A-01D-1494-08	3587167	100349053	90805223	18	290											
DCHS2	54798	broad.mit.edu	37	chr4	155157377	155157377	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgagtgagaaaacagggtgaTacaatagaataggtcaattc	11	4	1	4			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr4:155157377T>C	uc003inw.2	-	25	7062	c.7062A>G	c.(7060-7062)GTA>GTG	p.V2354V		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2354	Cadherin 21.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AACAGGGTGATACAATAGAAT	0.393													C	155157377	C	C	155157377	2	2	5	1	0	0	0	0	0	0	0	1	4288	1393	49	4		4	DCHS2	4	155157377	Silent	SNP	T	TCGA-02-2470-01A-01D-1494-08	54808324	155157377	35996899	19	291											
CCDC110	256309	broad.mit.edu	37	chr4	186381079	186381079	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcacagtaattttggatttaTccagaattactgtatcagct	7	7	1	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr4:186381079T>C	uc003ixu.3	-	6	738	c.662A>G	c.(661-663)GAT>GGT	p.D221G	CCDC110_uc003ixv.3_Missense_Mutation_p.D184G|CCDC110_uc011ckt.1_Missense_Mutation_p.D221G	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	221						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTTGGATTTATCCAGAATTAC	0.323													C	186381079	C	C	186381079	3	2	5	1	0	0	0	0	1	0	0	0	2747	1435	50	4	1847	4	CCDC110	4	186381079	Missense_Mutation	SNP	T	TCGA-02-2470-01A-01D-1494-08	31223702	186381079	4773197	20	292											
WDR70	55100	broad.mit.edu	37	chr5	37480065	37480065	+	Nonsense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtataaaaggagaccagtaTattgtggacatggccaacac	10	7	0	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr5:37480065T>G	uc003jkv.2	+	8	874	c.816T>G	c.(814-816)TAT>TAG	p.Y272*	WDR70_uc010iva.1_Nonsense_Mutation_p.Y272*	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	272										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGACCAGTATATTGTGGACA	0.328													G	37480065	G	G	37480065	4	3	5	1	0	0	0	0	0	1	0	0	17318	1413	49	5	846	5	WDR70	5	37480065	Nonsense_Mutation	SNP	T	TCGA-02-2470-01A-01D-1494-08		37480065	143435195	21	293											
C5orf34	375444	broad.mit.edu	37	chr5	43509299	43509299	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gacgaattctttctggttgtTctaaaggatgtgctgaaaca	10	6	3	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr5:43509299T>G	uc003jnz.1	-	3	460	c.143A>C	c.(142-144)GAA>GCA	p.E48A	C5orf34_uc011cpx.1_Intron	NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	48										breast(1)	1	Lung NSC(6;2.07e-05)					TTCTGGTTGTTCTAAAGGATG	0.328													G	43509299	G	G	43509299	3	3	5	1	0	0	0	0	1	0	0	0	2293	1783	62	5	1821	5	C5orf34	5	43509299	Missense_Mutation	SNP	T	TCGA-02-2470-01A-01D-1494-08	6029234	43509299	137405961	22	294											
ERGIC1	57222	broad.mit.edu	37	chr5	172336690	172336690	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaacgagctctatgtcgAtgacccagacaaggacagcg	12	10	1	3			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr5:172336690A>G	uc003mbw.3	+	4	370	c.176A>G	c.(175-177)GAT>GGT	p.D59G	ERGIC1_uc003mby.3_5'UTR|ERGIC1_uc011dfa.1_5'UTR|ERGIC1_uc003mbz.3_Missense_Mutation_p.D14G	NM_001031711	NP_001026881	Q969X5	ERGI1_HUMAN	endoplasmic reticulum-golgi intermediate	59	Lumenal (Potential).				ER to Golgi vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTCTATGTCGATGACCCAGAC	0.542													G	172336690	G	G	172336690	3	3	5	1	0	0	0	0	1	0	0	0	5223	333	12	4	190	4	ERGIC1	5	172336690	Missense_Mutation	SNP	A	TCGA-02-2470-01A-01D-1494-08	128827391	172336690	8578570	23	295											
KIF13A	63971	broad.mit.edu	37	chr6	17837205	17837205	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcattcacaacagcatggttCacaatccttttggctcggtc	7	12	3	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr6:17837205C>T	uc003ncg.3	-	11	1164	c.1059G>A	c.(1057-1059)GTG>GTA	p.V353V	KIF13A_uc003ncf.2_Silent_p.V353V|KIF13A_uc003nch.3_Silent_p.V353V|KIF13A_uc003nci.3_Silent_p.V353V|KIF13A_uc003ncj.2_Silent_p.V29V	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	353					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CAGCATGGTTCACAATCCTTT	0.502													T	17837205	T	T	17837205	2	4	5	1	0	0	0	0	0	0	0	1	8274	813	29	3		3	KIF13A	6	17837205	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08		17837205	153277862	24	296											
RFX6	222546	broad.mit.edu	37	chr6	117215161	117215161	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgctctaggtatcattactAtgggattggcatcaaagaga	10	6	3	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr6:117215161A>C	uc003pxm.2	+	5	641	c.578A>C	c.(577-579)TAT>TCT	p.Y193S		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	193	RFX-type winged-helix.				glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TATCATTACTATGGGATTGGC	0.413													C	117215161	C	C	117215161	3	2	5	1	0	0	0	0	1	0	0	0	13267	449	16	5	596	5	RFX6	6	117215161	Missense_Mutation	SNP	A	TCGA-02-2470-01A-01D-1494-08	99377956	117215161	53899906	25	297											
SYNJ2	8871	broad.mit.edu	37	chr6	158483196	158483196	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggggagaacgtcagtccacGgtgaggctcgctgcgcactg	17	11	1	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr6:158483196G>A	uc003qqx.1	+	8	1202	c.1127G>A	c.(1126-1128)CGT>CAT	p.R376H	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Missense_Mutation_p.R376H|SYNJ2_uc003qqy.1_Missense_Mutation_p.R89H|SYNJ2_uc011efn.1_Missense_Mutation_p.R304H|SYNJ2_uc010kjo.1_Missense_Mutation_p.R325H|SYNJ2_uc003qqz.1_5'UTR	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	376	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		GTCAGTCCACGGTGAGGCTCG	0.607													A	158483196	A	A	158483196	3	1	5	1	0	0	0	0	1	0	0	0	15450	1130	39	2	1157	2	SYNJ2	6	158483196	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	41268035	158483196	12631871	26	298											
IGFBP1	3484	broad.mit.edu	37	chr7	45932660	45932660	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagatcaggggagaccccaaCtgccagatatattttaatgt	10	8	1	3			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr7:45932660C>T	uc003tnp.2	+	4	1043	c.750C>T	c.(748-750)AAC>AAT	p.N250N	IGFBP1_uc003tno.3_Silent_p.N248N|IGFBP1_uc010kyn.2_Silent_p.N207N	NM_000596	NP_000587	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	250	Thyroglobulin type-1.					extracellular space	insulin-like growth factor binding			lung(1)	1						GAGACCCCAACTGCCAGATAT	0.433													T	45932660	T	T	45932660	2	4	5	1	0	0	0	0	0	0	0	1	7578	564	20	3		3	IGFBP1	7	45932660	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08		45932660	113206003	27	299											
PARP12	64761	broad.mit.edu	37	chr7	139726106	139726106	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaacagctgccgctcgtcCacggccttccctccgttctg	10	17	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr7:139726106C>T	uc003vvl.1	-	11	2545	c.1671G>A	c.(1669-1671)GTG>GTA	p.V557V	PARP12_uc003vvk.1_Silent_p.V343V|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	557	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					GCCGCTCGTCCACGGCCTTCC	0.572													T	139726106	T	T	139726106	2	4	5	1	0	0	0	0	0	0	0	1	11457	581	21	3		3	PARP12	7	139726106	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08	93793446	139726106	19412557	28	300											
CNTNAP2	26047	broad.mit.edu	37	chr7	146818164	146818164	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcactctgtggtcattgagcGccaggggcggagcattaacc	14	11	2	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr7:146818164G>A	uc003weu.1	+	6	1364	c.848G>A	c.(847-849)CGC>CAC	p.R283H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	283	Laminin G-like 1.|Extracellular (Potential).		R -> C.		behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTCATTGAGCGCCAGGGGCGG	0.532										HNSCC(39;0.1)			A	146818164	A	A	146818164	3	1	5	1	0	0	0	0	1	0	0	0	3647	1087	38	1	870	1	CNTNAP2	7	146818164	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	7092058	146818164	12320499	29	301											
MLL3	58508	broad.mit.edu	37	chr7	151962124	151962124	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aattgaaatgaaaacttactTgcagttctggcacactttgc	7	8	1	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr7:151962124T>C	uc003wla.2	-	8	1402	c.1183A>G	c.(1183-1185)AAA>GAA	p.K395E		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	395	PHD-type 2.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AAAACTTACTTGCAGTTCTGG	0.403			N		medulloblastoma								C	151962124	C	C	151962124	3	2	5	1	0	0	0	0	1	0	0	0	9622	1826	63	4	13760	4	MLL3	7	151962124	Missense_Mutation	SNP	T	TCGA-02-2470-01A-01D-1494-08	5143960	151962124	7176539	30	302											
NEFM	4741	broad.mit.edu	37	chr8	24772112	24772112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagacagacatctcgacggCgctgaaggaaatccgctccc	11	13	1	3			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr8:24772112C>T	uc003xed.3	+	1	839	c.806C>T	c.(805-807)GCG>GTG	p.A269V	NEFM_uc011lac.1_Missense_Mutation_p.A269V|NEFM_uc010lue.2_5'Flank|uc010luc.1_5'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	269	Rod.|Coil 2A.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		ATCTCGACGGCGCTGAAGGAA	0.592													T	24772112	T	T	24772112	3	4	5	1	0	0	0	0	1	0	0	0	10316	768	27	1	808	1	NEFM	8	24772112	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08		24772112	121591910	31	303											
CA9	768	broad.mit.edu	37	chr9	35674152	35674152	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgggcgaggaggatctgCccagtgaagaggattcaccc	14	11	2	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr9:35674152C>T	uc003zxo.3	+	1	238	c.196C>T	c.(196-198)CCC>TCC	p.P66S	C9orf100_uc003zxl.2_RNA|CA9_uc003zxn.1_RNA|CA9_uc003zxp.3_Missense_Mutation_p.P66S	NM_001216	NP_001207	Q16790	CAH9_HUMAN	carbonic anhydrase IX precursor	66	Extracellular.|Proteoglycan-like (PG).				one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			ovary(4)|skin(1)	5	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GGAGGATCTGCCCAGTGAAGA	0.592													T	35674152	T	T	35674152	3	4	5	1	0	0	0	0	1	0	0	0	2524	739	26	3	198	3	CA9	9	35674152	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08		35674152	105539279	32	304											
SPAG8	26206	broad.mit.edu	37	chr9	35810291	35810291	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaaggtctcaggttgctcctGgcggtagtcgtgaggctgtg	17	8	1	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr9:35810291G>T	uc003zye.2	-	6	1331	c.1216C>A	c.(1216-1218)CAG>AAG	p.Q406K	SPAG8_uc003zyf.2_Missense_Mutation_p.Q323K|SPAG8_uc003zyg.2_Missense_Mutation_p.Q406K	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	406						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			GGTTGCTCCTGGCGGTAGTCG	0.607													T	35810291	T	T	35810291	3	4	5	1	0	0	0	0	1	0	0	0	14984	1357	47	5	500	5	SPAG8	9	35810291	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	136139	35810291	105403140	33	305											
MELK	9833	broad.mit.edu	37	chr9	36651764	36651764	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggcagtatgatcacctcacgGctacctatcttctgcttcta	7	13	5	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr9:36651764G>T	uc003zzn.2	+	12	1081	c.943G>T	c.(943-945)GCT>TCT	p.A315S	MELK_uc011lpm.1_Missense_Mutation_p.A184S|MELK_uc011lpn.1_Missense_Mutation_p.A315S|MELK_uc011lpo.1_Missense_Mutation_p.A121S|MELK_uc010mll.2_Missense_Mutation_p.A283S|MELK_uc011lpp.1_Missense_Mutation_p.A267S|MELK_uc010mlm.2_Missense_Mutation_p.A244S|MELK_uc011lpq.1_Missense_Mutation_p.A121S|MELK_uc011lpr.1_Missense_Mutation_p.A244S|MELK_uc011lps.1_Missense_Mutation_p.A235S	NM_014791	NP_055606	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	315						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			TCACCTCACGGCTACCTATCT	0.403													T	36651764	T	T	36651764	3	4	5	1	0	0	0	0	1	0	0	0	9470	1203	42	5	985	5	MELK	9	36651764	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	841473	36651764	104561667	34	306											
FAM75A2	642265	broad.mit.edu	37	chr9	39888189	39888189	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggagagaactcgaaacagctGcccggacctcagaagttctc	11	12	2	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr9:39888189G>T	uc004abp.2	+	4	1205	c.1176G>T	c.(1174-1176)CTG>CTT	p.L392L		NM_001040065	NP_001035154	Q5RGS2	F75A2_HUMAN	hypothetical protein LOC642265	392						integral to membrane					0				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CGAAACAGCTGCCCGGACCTC	0.488													T	39888189	T	T	39888189	2	4	5	1	0	0	0	0	0	0	0	1	5620	1306	46	5		5	FAM75A2	9	39888189	Silent	SNP	G	TCGA-02-2470-01A-01D-1494-08	3236425	39888189	101325242	35	307											
SH2D3C	10044	broad.mit.edu	37	chr9	130502108	130502108	+	Frame_Shift_Del	DEL	C	-	-													tggtggggccgagtcacactCcagcagggtgatgaggggca							TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr9:130502108delC	uc004bsc.2	-	11	2402	c.2260delG	c.(2260-2262)GAGfs	p.E754fs	SH2D3C_uc010mxo.2_Frame_Shift_Del_p.E594fs|SH2D3C_uc004bry.2_Frame_Shift_Del_p.E596fs|SH2D3C_uc004brz.3_Frame_Shift_Del_p.E400fs|SH2D3C_uc011mak.1_Frame_Shift_Del_p.E400fs|SH2D3C_uc004bsa.2_Frame_Shift_Del_p.E597fs|SH2D3C_uc004bsb.2_Frame_Shift_Del_p.E686fs	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	754	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						GAGTCACACTCCAGCAGGGTG	0.657													-	130502108	-	-	130502108	7	5	5	1	0	1	0	1	0	0	0	0	14234	864	30	0	330	0	SH2D3C	9	130502108	Frame_Shift_Del	DEL	C	TCGA-02-2470-01A-01D-1494-08	90613919	130502108	10711323	36	308											
STAM	8027	broad.mit.edu	37	chr10	17735226	17735226	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctcttttttgttaggctgcAgaacaagcaaaagcaagccc	8	11	1	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr10:17735226A>G	uc001ipj.1	+	6	666	c.450A>G	c.(448-450)GCA>GCG	p.A150A	STAM_uc010qcf.1_Silent_p.A39A|STAM_uc009xjw.1_5'Flank	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	150					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						GTTAGGCTGCAGAACAAGCAA	0.408													G	17735226	G	G	17735226	2	3	5	1	0	0	0	0	0	0	0	1	15247	175	7	4		4	STAM	10	17735226	Silent	SNP	A	TCGA-02-2470-01A-01D-1494-08		17735226	117799521	37	309											
NEBL	10529	broad.mit.edu	37	chr10	21461321	21461321	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acaatacttacgcattacaaTagggcttcttttcatagcct	5	10	2	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr10:21461321T>C	uc001iqk.2	-	2	509	c.155A>G	c.(154-156)TAT>TGT	p.Y52C		NM_213569	NP_998734	O76041	NEBL_HUMAN	nebulette non-muscle isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CGCATTACAATAGGGCTTCTT	0.438													C	21461321	C	C	21461321	3	2	5	1	0	0	0	0	1	0	0	0	10303	1406	49	4	3370	4	NEBL	10	21461321	Missense_Mutation	SNP	T	TCGA-02-2470-01A-01D-1494-08	3726095	21461321	114073426	38	310											
SVIL	6840	broad.mit.edu	37	chr10	29839574	29839574	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcaccaaaggaggggctcCgggaggctgcctgctgcagg	18	11	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr10:29839574C>T	uc001iut.1	-	6	1532	c.779G>A	c.(778-780)CGG>CAG	p.R260Q	SVIL_uc001iuu.1_Missense_Mutation_p.R260Q|SVIL_uc009xld.1_Missense_Mutation_p.R260Q	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	260					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				GGAGGGGCTCCGGGAGGCTGC	0.612													T	29839574	T	T	29839574	3	4	5	1	0	0	0	0	1	0	0	0	15418	652	23	2	5997	2	SVIL	10	29839574	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	8378253	29839574	105695173	39	311											
KIAA1462	57608	broad.mit.edu	37	chr10	30315760	30315760	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcaggctggttctgtcccGctctccggatgcccggcagg	14	15	2	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr10:30315760G>A	uc001iux.2	-	2	3376	c.3317C>T	c.(3316-3318)GCG>GTG	p.A1106V	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.A968V|KIAA1462_uc009xle.1_Missense_Mutation_p.A1106V	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1106										ovary(4)	4						GTTCTGTCCCGCTCTCCGGAT	0.637													A	30315760	A	A	30315760	3	1	5	1	0	0	0	0	1	0	0	0	8234	1087	38	1	770	1	KIAA1462	10	30315760	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	476186	30315760	105218987	40	312											
PTEN	5728	broad.mit.edu	37	chr10	89717672	89717672	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctccaattcaggacccacaCgacgggaagacaagttcatg	9	13	2	1	rs121909219		TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr10:89717672C>T	uc001kfb.2	+	8	1728	c.697C>T	c.(697-699)CGA>TGA	p.R233*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R233*(61)|p.R233fs*10(4)|p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R233fs*25(1)|p.R233fs*23(1)|p.R233R(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGGACCCACACGACGGGAAGA	0.423	R233*(JHUEM1_ENDOMETRIUM)|R233*(SW1783_CENTRAL_NERVOUS_SYSTEM)|R233*(NCIH1155_LUNG)|R233*(SF295_CENTRAL_NERVOUS_SYSTEM)|R233*(HEC59_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89717672	T	T	89717672	4	4	5	1	0	0	0	0	0	1	0	0	12738	528	19	1	723	1	PTEN	10	89717672	Nonsense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	59401912	89717672	45817075	41	313											
ANO3	63982	broad.mit.edu	37	chr11	26569054	26569054	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcaattgttggtttgtgcGttttcttctatggattattt	9	5	2	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr11:26569054G>A	uc001mqt.3	+	12	1391	c.1246G>A	c.(1246-1248)GTT>ATT	p.V416I	ANO3_uc010rdr.1_Missense_Mutation_p.V400I|ANO3_uc010rds.1_Missense_Mutation_p.V255I|ANO3_uc010rdt.1_Missense_Mutation_p.V270I	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	416	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGGTTTGTGCGTTTTCTTCTA	0.373													A	26569054	A	A	26569054	3	1	5	1	0	0	0	0	1	0	0	0	698	1145	40	1	1292	1	ANO3	11	26569054	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08		26569054	108437462	42	314											
OR5D13	390142	broad.mit.edu	37	chr11	55541619	55541619	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatgcgatctgcaagtgggCgccagaaaactttctccacc	10	12	2	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr11:55541619C>T	uc010ril.1	+	1	706	c.706C>T	c.(706-708)CGC>TGC	p.R236C		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TGCAAGTGGGCGCCAGAAAAC	0.408													T	55541619	T	T	55541619	3	4	5	1	0	0	0	0	1	0	0	0	11154	768	27	1	708	1	OR5D13	11	55541619	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	28972565	55541619	79464897	43	315											
OR10V1	390201	broad.mit.edu	37	chr11	59481032	59481032	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatctgggtgccacatcccGtgatggaaacaggagttttg	12	9	1	1	rs144835634		TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr11:59481032G>A	uc001nof.1	-	1	287	c.287C>T	c.(286-288)ACG>ATG	p.T96M		NM_001005324	NP_001005324	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCACATCCCGTGATGGAAAC	0.473													A	59481032	A	A	59481032	3	1	5	1	0	0	0	0	1	0	0	0	10920	1145	40	1	646	1	OR10V1	11	59481032	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	3939413	59481032	75525484	44	316											
CAPN1	823	broad.mit.edu	37	chr11	64953733	64953733	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccgagtggtacgagttgcGcaaggctcccagtgacctct	12	12	1	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr11:64953733G>A	uc009yqd.1	+	6	794	c.683G>A	c.(682-684)CGC>CAC	p.R228H	CAPN1_uc001odf.1_Missense_Mutation_p.R228H|CAPN1_uc001odg.1_Missense_Mutation_p.R228H|CAPN1_uc010roa.1_5'UTR	NM_005186	NP_005177	P07384	CAN1_HUMAN	calpain 1, large subunit	228	Calpain catalytic.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		TACGAGTTGCGCAAGGCTCCC	0.637													A	64953733	A	A	64953733	3	1	5	1	0	0	0	0	1	0	0	0	2622	1087	38	1	701	1	CAPN1	11	64953733	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	5472701	64953733	70052783	45	317											
TMEM123	114908	broad.mit.edu	37	chr11	102272678	102272678	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaagcagcagatgtcactgaActattgtgggttacggtcat	12	7	2	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr11:102272678A>G	uc001pha.2	-	3	838	c.417T>C	c.(415-417)AGT>AGC	p.S139S	TMEM123_uc009yxc.2_Silent_p.S120S	NM_052932	NP_443164	Q8N131	PORIM_HUMAN	transmembrane protein 123 precursor	139	Thr-rich.|Extracellular (Potential).				oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(2)	2	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		ATGTCACTGAACTATTGTGGG	0.363													G	102272678	G	G	102272678	2	3	5	1	0	0	0	0	0	0	0	1	16033	40	2	4		4	TMEM123	11	102272678	Silent	SNP	A	TCGA-02-2470-01A-01D-1494-08	37318945	102272678	32733838	46	318											
RAPGEF3	10411	broad.mit.edu	37	chr12	48143197	48143197	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgatacggttgaagtcctgCttgtccacacgcaggaaatg	11	9	0	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr12:48143197C>A	uc009zkp.2	-	9	1331	c.891G>T	c.(889-891)AAG>AAT	p.K297N	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Missense_Mutation_p.K297N|RAPGEF3_uc001rpz.3_Missense_Mutation_p.K339N|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Missense_Mutation_p.K351N|RAPGEF3_uc001rqb.3_Missense_Mutation_p.K339N	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	297					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		TGAAGTCCTGCTTGTCCACAC	0.562													A	48143197	A	A	48143197	3	1	5	1	0	0	0	0	1	0	0	0	13045	796	28	5	1830	5	RAPGEF3	12	48143197	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08		48143197	85708698	47	319											
SRRM4	84530	broad.mit.edu	37	chr12	119588965	119588965	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctccagtcactcgtcccgatCcccaaatcccagggcttccc	6	20	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr12:119588965C>G	uc001txa.1	+	10	1512	c.1220C>G	c.(1219-1221)TCC>TGC	p.S407C		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	407	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						TCGTCCCGATCCCCAAATCCC	0.572													G	119588965	G	G	119588965	3	3	5	1	0	0	0	0	1	0	0	0	15170	855	30	5	1258	5	SRRM4	12	119588965	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	71445768	119588965	14262930	48	320											
RIMBP2	23504	broad.mit.edu	37	chr12	130898833	130898833	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catagaagtctggagaaaggCggtctcgcccgtaatcgtct	12	10	3	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr12:130898833C>T	uc001uil.2	-	14	2653	c.2489G>A	c.(2488-2490)CGC>CAC	p.R830H		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	830						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGGAGAAAGGCGGTCTCGCCC	0.572													T	130898833	T	T	130898833	3	4	5	1	0	0	0	0	1	0	0	0	13363	768	27	1	693	1	RIMBP2	12	130898833	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	11309868	130898833	2953062	49	321											
FGF14	2259	broad.mit.edu	37	chr13	102375254	102375254	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacttgtgcttttacttggcGtcaccccaggcttcgggacc	10	14	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr13:102375254G>A	uc001vpe.2	-	5	671	c.671C>T	c.(670-672)ACG>ATG	p.T224M	FGF14_uc001vpf.2_Missense_Mutation_p.T229M|FGF14_uc001vpd.1_5'Flank	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	224					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTTACTTGGCGTCACCCCAGG	0.473													A	102375254	A	A	102375254	3	1	5	1	0	0	0	0	1	0	0	0	5843	1145	40	1	76	1	FGF14	13	102375254	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08		102375254	12794624	50	322											
C14orf39	317761	broad.mit.edu	37	chr14	60951623	60951623	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aattctttgaatcatctcttCtttagtacttatgtcttgct	4	8	5	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr14:60951623C>T	uc001xez.3	-	3	192	c.82G>A	c.(82-84)GAA>AAA	p.E28K	C14orf39_uc010apo.2_5'UTR	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	28										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		ATCATCTCTTCTTTAGTACTT	0.264													T	60951623	T	T	60951623	3	4	5	1	0	0	0	0	1	0	0	0	1772	922	32	3	1745	3	C14orf39	14	60951623	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08		60951623	46397917	51	323											
DLK1	8788	broad.mit.edu	37	chr14	101201218	101201218	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttcagcaaggaggccggCgacgaggagatctaagcagc	14	11	2	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr14:101201218C>T	uc001yhs.3	+	5	1290	c.1137C>T	c.(1135-1137)GGC>GGT	p.G379G	DLK1_uc001yhu.3_Silent_p.G306G	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	379	Cytoplasmic (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				AGGAGGCCGGCGACGAGGAGA	0.552													T	101201218	T	T	101201218	2	4	5	1	0	0	0	0	0	0	0	1	4564	755	27	1		1	DLK1	14	101201218	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08	40249595	101201218	6148322	52	324											
TDRD9	122402	broad.mit.edu	37	chr14	104508512	104508512	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcttcaagacattgcccgtcAgaagcttttagggtaagctg	11	9	2	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr14:104508512A>C	uc001yom.3	+	34	3992	c.3962A>C	c.(3961-3963)CAG>CCG	p.Q1321P	TDRD9_uc001yon.3_Missense_Mutation_p.Q868P	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	1321					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				ATTGCCCGTCAGAAGCTTTTA	0.478													C	104508512	C	C	104508512	3	2	5	1	0	0	0	0	1	0	0	0	15733	188	7	5	4096	5	TDRD9	14	104508512	Missense_Mutation	SNP	A	TCGA-02-2470-01A-01D-1494-08	3307294	104508512	2841028	53	325											
TGM5	9333	broad.mit.edu	37	chr15	43552356	43552356	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagaggtaccgacccacggcCgccgtgggaggagcgcacaa	15	13	0	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr15:43552356C>T	uc001zrd.1	-	3	338	c.330G>A	c.(328-330)GCG>GCA	p.A110A	TGM5_uc001zre.1_Intron	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	110					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GACCCACGGCCGCCGTGGGAG	0.617													T	43552356	T	T	43552356	2	4	5	1	0	0	0	0	0	0	0	1	15830	639	23	2		2	TGM5	15	43552356	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08		43552356	58979036	54	326											
DET1	55070	broad.mit.edu	37	chr15	89056199	89056199	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacctacgtgcagcagtgtcGcatatggaagttgacaacat	10	10	0	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr15:89056199G>A	uc002bmr.2	-	5	1788	c.1636C>T	c.(1636-1638)CGA>TGA	p.R546*	DET1_uc002bmp.3_RNA|DET1_uc010bnk.2_RNA|DET1_uc002bmq.2_Nonsense_Mutation_p.R557*	NM_001144074	NP_001137546	Q7L5Y6	DET1_HUMAN	de-etiolated 1 isoform 2	546						nucleus				lung(1)|pancreas(1)	2	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			CAGCAGTGTCGCATATGGAAG	0.498													A	89056199	A	A	89056199	4	1	5	1	0	0	0	0	0	1	0	0	4450	1095	38	1	20	1	DET1	15	89056199	Nonsense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	45503843	89056199	13475193	55	327											
DET1	55070	broad.mit.edu	37	chr15	89073948	89073948	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaagctgcattttccacattCgcagctgccgcagttggtca	10	12	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr15:89073948C>T	uc002bmr.2	-	2	1141	c.989G>A	c.(988-990)CGA>CAA	p.R330Q	DET1_uc002bmp.3_RNA|DET1_uc010bnk.2_RNA|DET1_uc002bmq.2_Missense_Mutation_p.R341Q	NM_001144074	NP_001137546	Q7L5Y6	DET1_HUMAN	de-etiolated 1 isoform 2	330						nucleus				lung(1)|pancreas(1)	2	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			TTTCCACATTCGCAGCTGCCG	0.493													T	89073948	T	T	89073948	3	4	5	1	0	0	0	0	1	0	0	0	4450	884	31	2	679	2	DET1	15	89073948	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	17749	89073948	13457444	56	328											
ITGAX	3687	broad.mit.edu	37	chr16	31368588	31368588	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccaggcctgcggccccacCgtgcaccacgagtgcgggag	14	18	0	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr16:31368588C>T	uc002ebu.1	+	5	400	c.333C>T	c.(331-333)ACC>ACT	p.T111T	ITGAX_uc010cao.1_3'UTR|ITGAX_uc002ebt.2_Silent_p.T111T	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	111	FG-GAP 2.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCGGCCCCACCGTGCACCACG	0.687													T	31368588	T	T	31368588	2	4	5	1	0	0	0	0	0	0	0	1	7889	639	23	2		2	ITGAX	16	31368588	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08		31368588	58986165	57	329											
CCDC135	84229	broad.mit.edu	37	chr16	57760043	57760043	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaggacgtggcagagcgcGtgtttctggtcgcggaggag	20	7	1	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr16:57760043G>A	uc002emi.2	+	13	1911	c.1822G>A	c.(1822-1824)GTG>ATG	p.V608M	CCDC135_uc002emj.2_Missense_Mutation_p.V608M|CCDC135_uc002emk.2_Missense_Mutation_p.V543M	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	608						cytoplasm				central_nervous_system(1)	1						GGCAGAGCGCGTGTTTCTGGT	0.627													A	57760043	A	A	57760043	3	1	5	1	0	0	0	0	1	0	0	0	2769	1145	40	1	1868	1	CCDC135	16	57760043	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	26391455	57760043	32594710	58	330											
DLG4	1742	broad.mit.edu	37	chr17	7121951	7121951	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gccaggagccagagggctgaCctgggagctagtgagatgca	17	9	0	3			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr17:7121951C>G	uc002get.3	-	2	1228	c.27G>C	c.(25-27)AGG>AGC	p.R9S	DLG4_uc010cly.2_5'Flank|DLG4_uc010vto.1_Missense_Mutation_p.R9S|DLG4_uc002geu.2_5'Flank|ACADVL_uc010vtp.1_Intron|ACADVL_uc010vtq.1_5'Flank|ACADVL_uc002gev.2_5'Flank|ACADVL_uc002gew.2_5'Flank|ACADVL_uc002gex.2_5'Flank	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	Error:Variant_position_missing_in_P78352_after_alignment					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						AGAGGGCTGACCTGGGAGCTA	0.592													G	7121951	G	G	7121951	3	3	5	1	0	0	0	0	1	0	0	0	4557	506	18	5	2394	5	DLG4	17	7121951	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08		7121951	74073259	59	331											
C17orf102	400591	broad.mit.edu	37	chr17	32905952	32905952	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cccagcaacagaataaatagGtttcccacagctgcgccccg	8	15	0	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr17:32905952G>T	uc002hie.1	-	1	437	c.348C>A	c.(346-348)AAC>AAA	p.N116K	TMEM132E_uc002hif.2_5'Flank	NM_207454	NP_997337	A2RUQ5	CQ102_HUMAN	hypothetical protein LOC400591	116										ovary(1)	1						GAATAAATAGGTTTCCCACAG	0.607													T	32905952	T	T	32905952	3	4	5	1	0	0	0	0	1	0	0	0	1849	1252	44	5	163	5	C17orf102	17	32905952	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	25784001	32905952	48289258	60	332											
GGNBP2	79893	broad.mit.edu	37	chr17	34943625	34943625	+	Frame_Shift_Del	DEL	T	-	-													ttgcagaacctacagaaacgTtgtttggtcccgattccgga							TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr17:34943625delT	uc002hnb.2	+	13	2089	c.1840delT	c.(1840-1842)TTGfs	p.L614fs		NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	614					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		TACAGAAACGTTGTTTGGTCC	0.463													-	34943625	-	-	34943625	7	5	5	1	0	1	0	1	0	0	0	0	6359	1722	60	0	1886	0	GGNBP2	17	34943625	Frame_Shift_Del	DEL	T	TCGA-02-2470-01A-01D-1494-08	2037673	34943625	46251585	61	333											
C17orf71	55181	broad.mit.edu	37	chr17	57292254	57292254	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggcctttgggttttgagatTtccttatgcatatgtgactg	11	6	0	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr17:57292254T>G	uc002ixi.2	+	4	2909	c.2867T>G	c.(2866-2868)TTT>TGT	p.F956C		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	956					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					GTTTTGAGATTTCCTTATGCA	0.473													G	57292254	G	G	57292254	3	3	5	1	0	0	0	0	1	0	0	0	1878	1841	64	5	2881	5	C17orf71	17	57292254	Missense_Mutation	SNP	T	TCGA-02-2470-01A-01D-1494-08	22348629	57292254	23902956	62	334											
CTAGE1	64693	broad.mit.edu	37	chr18	19995570	19995570	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gctggggggaaaaatgcaggTcttgggggacggtaaggaag	20	4	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr18:19995570T>A	uc002ktv.1	-	1	2309	c.2205A>T	c.(2203-2205)AGA>AGT	p.R735S		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	735	Pro-rich.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AAAATGCAGGTCTTGGGGGAC	0.483													A	19995570	A	A	19995570	3	1	5	1	0	0	0	0	1	0	0	0	3992	1664	58	5	36	5	CTAGE1	18	19995570	Missense_Mutation	SNP	T	TCGA-02-2470-01A-01D-1494-08		19995570	58081678	63	335											
TCEB3B	51224	broad.mit.edu	37	chr18	44560403	44560403	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttggattcgtttgctttcctTtgtttatctccaagtgcagt	8	8	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr18:44560403T>C	uc002lcr.1	-	1	1586	c.1233A>G	c.(1231-1233)CAA>CAG	p.Q411Q	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	411					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TTGCTTTCCTTTGTTTATCTC	0.502													C	44560403	C	C	44560403	2	2	5	1	0	0	0	0	0	0	0	1	15679	1838	64	4		4	TCEB3B	18	44560403	Silent	SNP	T	TCGA-02-2470-01A-01D-1494-08	24564833	44560403	33516845	64	336											
MALT1	10892	broad.mit.edu	37	chr18	56400716	56400716	+	Frame_Shift_Del	DEL	A	-	-													tccaaatccatataggtctgAaaattgtctgtgtgtacaaa							TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr18:56400716delA	uc002lhm.1	+	11	1568	c.1310delA	c.(1309-1311)GAAfs	p.E437fs	MALT1_uc002lhn.1_Frame_Shift_Del_p.E426fs	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	437	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						TATAGGTCTGAAAATTGTCTG	0.348			T	BIRC3	MALT								-	56400716	-	-	56400716	7	5	5	1	0	1	0	1	0	0	0	0	9202	246	9	0	1352	0	MALT1	18	56400716	Frame_Shift_Del	DEL	A	TCGA-02-2470-01A-01D-1494-08	11840313	56400716	21676532	65	337											
TNFRSF11A	8792	broad.mit.edu	37	chr18	60025550	60025550	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctgatgccttttcctccaCggacaaatgcagaccctgga	8	14	1	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr18:60025550C>T	uc002lin.2	+	5	535	c.497C>T	c.(496-498)ACG>ATG	p.T166M	TNFRSF11A_uc010dpv.2_Missense_Mutation_p.T166M	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	166	TNFR-Cys 4.|Extracellular (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				TTTTCCTCCACGGACAAATGC	0.448									Paget_Disease_of_Bone				T	60025550	T	T	60025550	3	4	5	1	0	0	0	0	1	0	0	0	16281	536	19	1	515	1	TNFRSF11A	18	60025550	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	3624834	60025550	18051698	66	338											
TJP3	27134	broad.mit.edu	37	chr19	3730053	3730053	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccacatcgtcatggtgaaCggggtttccatggagaatgc	13	9	1	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr19:3730053C>T	uc010xhv.1	+	3	243	c.243C>T	c.(241-243)AAC>AAT	p.N81N	TJP3_uc010xhs.1_Silent_p.N62N|TJP3_uc010xht.1_Silent_p.N26N|TJP3_uc010xhu.1_Silent_p.N71N|TJP3_uc010xhw.1_Silent_p.N81N	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	62	PDZ 1.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		TCATGGTGAACGGGGTTTCCA	0.597													T	3730053	T	T	3730053	2	4	5	1	0	0	0	0	0	0	0	1	15928	535	19	1		1	TJP3	19	3730053	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08		3730053	55398930	67	339											
MATK	4145	broad.mit.edu	37	chr19	3783147	3783147	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggccagctcctcctcggccGacttggtcccgtgtttccgc	11	17	0	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr19:3783147G>A	uc002lyt.2	-	7	1053	c.653C>T	c.(652-654)TCG>TTG	p.S218L	MATK_uc002lyv.2_Missense_Mutation_p.S219L|MATK_uc002lyu.2_Missense_Mutation_p.S177L|MATK_uc010dtq.2_Missense_Mutation_p.S218L	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	218					cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCTCGGCCGACTTGGTCCC	0.657													A	3783147	A	A	3783147	3	1	5	1	0	0	0	0	1	0	0	0	9332	1059	37	2	902	2	MATK	19	3783147	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	53094	3783147	55345836	68	340											
TMEM146	257062	broad.mit.edu	37	chr19	5757927	5757927	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cggttacacatcagatgggaAcaccaagtacaaactggtga	10	9	1	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr19:5757927A>G	uc002mda.2	+	14	1413	c.1352A>G	c.(1351-1353)AAC>AGC	p.N451S	TMEM146_uc010duj.1_Missense_Mutation_p.N109S	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	451	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCAGATGGGAACACCAAGTAC	0.567													G	5757927	G	G	5757927	3	3	5	1	0	0	0	0	1	0	0	0	16057	43	2	4	1406	4	TMEM146	19	5757927	Missense_Mutation	SNP	A	TCGA-02-2470-01A-01D-1494-08	1974780	5757927	53371056	69	341											
NFIX	4784	broad.mit.edu	37	chr19	13192662	13192662	+	Frame_Shift_Del	DEL	C	-	-													ggatggctcgggccaggccaCcggacaggtgagtccagagg							TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr19:13192662delC	uc010xmx.1	+	8	1324	c.1271delC	c.(1270-1272)ACCfs	p.T424fs	NFIX_uc002mwd.2_Frame_Shift_Del_p.T416fs|NFIX_uc002mwe.2_Frame_Shift_Del_p.T408fs|NFIX_uc002mwf.2_Frame_Shift_Del_p.T378fs|NFIX_uc002mwg.1_Frame_Shift_Del_p.T415fs			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	416					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			GGCCAGGCCACCGGACAGGTG	0.612											OREG0025286	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	13192662	-	-	13192662	7	5	5	1	0	1	0	1	0	0	0	0	10374	507	18	0	1277	0	NFIX	19	13192662	Frame_Shift_Del	DEL	C	TCGA-02-2470-01A-01D-1494-08	7434735	13192662	45936321	70	342											
NPHS1	4868	broad.mit.edu	37	chr19	36340038	36340038	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgccccacgctgtggacacCggctggccattctggagaca	13	14	1	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr19:36340038C>T	uc002oby.2	-	8	852	c.852G>A	c.(850-852)CCG>CCA	p.P284P		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	284	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGTGGACACCGGCTGGCCAT	0.677													T	36340038	T	T	36340038	2	4	5	1	0	0	0	0	0	0	0	1	10582	639	23	2		2	NPHS1	19	36340038	Silent	SNP	C	TCGA-02-2470-01A-01D-1494-08	23147376	36340038	22788945	71	343											
ZNF526	116115	broad.mit.edu	37	chr19	42730344	42730344	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgcatcagcgggtccatgccCgagctcggactttgacgcta	12	13	1	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr19:42730344C>G	uc002osz.1	+	3	1945	c.1789C>G	c.(1789-1791)CGA>GGA	p.R597G		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	597					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				GGTCCATGCCCGAGCTCGGAC	0.612													G	42730344	G	G	42730344	3	3	5	1	0	0	0	0	1	0	0	0	17964	644	23	5	1791	5	ZNF526	19	42730344	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	6390306	42730344	16398639	72	344											
ZNF667	63934	broad.mit.edu	37	chr19	56953854	56953859	+	In_Frame_Del	DEL	CTTCTC	-	-													caattactgcattcaaaaggCttctctcctgtatgaatgtt							TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr19:56953854_56953859delCTTCTC	uc002qnd.2	-	5	667_672	c.505_510delGAGAAG	c.(505-510)GAGAAGdel	p.EK169del	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_In_Frame_Del_p.EK169del|ZNF667_uc010etm.2_In_Frame_Del_p.EK112del	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	169_170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		ATTCAAAAGGCTTCTCTCCTGTATGA	0.374													-	56953859	-	-	56953854	7	5	5	1	0	1	0	1	0	0	0	0	18071	796	28	0	1326	0	ZNF667	19	56953854	In_Frame_Del	DEL	CTTCTC	TCGA-02-2470-01A-01D-1494-08	14223510	56953854	2175129	73	345											
ZNF606	80095	broad.mit.edu	37	chr19	58490980	58490980	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgatgttccataaaggatgaGaaataaaagatattctcata	7	4	1	3			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr19:58490980G>C	uc002qqw.2	-	7	1686	c.1068C>G	c.(1066-1068)TTC>TTG	p.F356L	ZNF606_uc010yhp.1_Missense_Mutation_p.F266L	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TAAAGGATGAGAAATAAAAGA	0.333													C	58490980	C	C	58490980	3	2	5	1	0	0	0	0	1	0	0	0	18029	933	33	5	1314	5	ZNF606	19	58490980	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	1537126	58490980	638003	74	346											
PLCB4	5332	broad.mit.edu	37	chr20	9417712	9417712	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaaaggaaaggccaacaccGccaaagcaaatgtgacccct	9	12	0	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr20:9417712G>A	uc002wnf.2	+	28	2777	c.2641G>A	c.(2641-2643)GCC>ACC	p.A881T	PLCB4_uc010gbw.1_Missense_Mutation_p.A881T|PLCB4_uc010gbx.2_Missense_Mutation_p.A893T|PLCB4_uc002wne.2_Missense_Mutation_p.A881T|PLCB4_uc002wnh.2_Missense_Mutation_p.A728T	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	881					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GGCCAACACCGCCAAAGCAAA	0.512													A	9417712	A	A	9417712	3	1	5	1	0	0	0	0	1	0	0	0	12030	1087	38	1	2783	1	PLCB4	20	9417712	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08		9417712	53607808	75	347											
KIF16B	55614	broad.mit.edu	37	chr20	16506810	16506810	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agtcataggtgaaggtcttgGtccgttctcttcctgagtcc	11	10	3	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr20:16506810G>C	uc002wpg.1	-	3	316	c.158C>G	c.(157-159)ACC>AGC	p.T53S	KIF16B_uc010gch.1_Missense_Mutation_p.T53S|KIF16B_uc010gci.1_Missense_Mutation_p.T53S|KIF16B_uc010gcj.1_Missense_Mutation_p.T53S	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	53	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GAAGGTCTTGGTCCGTTCTCT	0.353													C	16506810	C	C	16506810	3	2	5	1	0	0	0	0	1	0	0	0	8278	1261	44	5	3891	5	KIF16B	20	16506810	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08	7089098	16506810	46518710	76	348											
SSTR4	6754	broad.mit.edu	37	chr20	23016581	23016581	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtggtgcaccctctgcgcgCggcgacctaccggcggccca	14	18	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr20:23016581C>T	uc002wsr.2	+	1	525	c.461C>T	c.(460-462)GCG>GTG	p.A154V		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	154	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCTCTGCGCGCGGCGACCTAC	0.662													T	23016581	T	T	23016581	3	4	5	1	0	0	0	0	1	0	0	0	15199	768	27	1	463	1	SSTR4	20	23016581	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	6509771	23016581	40008939	77	349											
BPIL1	80341	broad.mit.edu	37	chr20	31606072	31606072	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggtttcatgaaggcctcaaCcccgtgggtcctgagtccca	11	13	2	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr20:31606072C>G	uc002wyj.2	+	8	779	c.585C>G	c.(583-585)AAC>AAG	p.N195K		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	195						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						AAGGCCTCAACCCCGTGGGTC	0.473													G	31606072	G	G	31606072	3	3	5	1	0	0	0	0	1	0	0	0	1491	506	18	5	611	5	BPIL1	20	31606072	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	8589491	31606072	31419448	78	350											
PPP1R16B	26051	broad.mit.edu	37	chr20	37534721	37534721	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggagcccctgcatgcagCtgccttctggggacaggtag	15	12	1	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr20:37534721C>T	uc002xje.2	+	7	995	c.806C>T	c.(805-807)GCT>GTT	p.A269V	PPP1R16B_uc010ggc.2_Intron	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	269	ANK 4.				regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CTGCATGCAGCTGCCTTCTGG	0.607													T	37534721	T	T	37534721	3	4	5	1	0	0	0	0	1	0	0	0	12366	797	28	3	828	3	PPP1R16B	20	37534721	Missense_Mutation	SNP	C	TCGA-02-2470-01A-01D-1494-08	5928649	37534721	25490799	79	351											
MX2	4600	broad.mit.edu	37	chr21	42773954	42773954	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaagcagtatcgaggcaaggAgcttctgggatttgtcaact	12	7	2	0			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chr21:42773954A>G	uc002yzf.1	+	11	1576	c.1472A>G	c.(1471-1473)GAG>GGG	p.E491G	MX2_uc002yzg.1_Missense_Mutation_p.E214G|MX2_uc010gop.1_5'UTR	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	491					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				CGAGGCAAGGAGCTTCTGGGA	0.433													G	42773954	G	G	42773954	3	3	5	1	0	0	0	0	1	0	0	0	9998	304	11	4	1510	4	MX2	21	42773954	Missense_Mutation	SNP	A	TCGA-02-2470-01A-01D-1494-08		42773954	5355941	80	352											
MAGEB18	286514	broad.mit.edu	37	chrX	26157158	26157158	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagaaacgccaccaggctcGttgtgagaatcaggatctgg	13	9	2	2			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chrX:26157158G>A	uc004dbq.1	+	2	243	c.56G>A	c.(55-57)CGT>CAT	p.R19H		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	19							protein binding			central_nervous_system(1)	1						CACCAGGCTCGTTGTGAGAAT	0.532													A	26157158	A	A	26157158	3	1	5	1	0	0	0	0	1	0	0	0	9175	1145	40	1	58	1	MAGEB18	23	26157158	Missense_Mutation	SNP	G	TCGA-02-2470-01A-01D-1494-08		26157158	129113402	81	353											
CXorf48	54967	broad.mit.edu	37	chrX	134294392	134294392	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tactaatataaatattatctTcatttatagaagtaacacat	2	5	2	1			TCGA-02-2470-01A-01D-1494-08	TCGA-02-2470-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0b35f2ff-2a08-4585-a1a9-cfc6a9f5b224	1ab37cba-6ad6-4825-98bb-b8e102f64ed2	g.chrX:134294392T>C	uc004eyk.1	-	3	1024	c.368A>G	c.(367-369)GAA>GGA	p.E123G	CXorf48_uc004eyl.1_Missense_Mutation_p.E123G	NM_001031705	NP_001026875	Q8WUE5	CX048_HUMAN	hypothetical protein LOC54967 isoform 1	123											0	Acute lymphoblastic leukemia(192;0.000127)					AATATTATCTTCATTTATAGA	0.308													C	134294392	C	C	134294392	3	2	5	1	0	0	0	0	1	0	0	0	4111	1783	62	4	446	4	CXorf48	23	134294392	Missense_Mutation	SNP	T	TCGA-02-2470-01A-01D-1494-08	108137234	134294392	20976168	82	354											
PHACTR4	65979	broad.mit.edu	37	chr1	28800112	28800112	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtacattgttatcaaaaccGtccccacccttaccacctaa	4	15	1	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:28800112G>A	uc001bpw.2	+	7	1152	c.870G>A	c.(868-870)CCG>CCA	p.P290P	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Silent_p.P274P|PHACTR4_uc001bpy.2_Silent_p.P300P	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	290	Pro-rich.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TATCAAAACCGTCCCCACCCT	0.463													A	28800112	A	A	28800112	2	1	6	1	0	0	0	0	0	0	0	1	11812	1132	40	1		1	PHACTR4	1	28800112	Silent	SNP	G	TCGA-02-2483-01A-01D-1494-08		28800112	220450509	1	355											
C1orf141	400757	broad.mit.edu	37	chr1	67561965	67561965	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatcaccttctaagagaccaAcagaatccaatggtttccta	5	11	2	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:67561965A>G	uc001ddl.1	-	5	497	c.386T>C	c.(385-387)GTT>GCT	p.V129A	C1orf141_uc001ddm.1_Missense_Mutation_p.V129A|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	129										ovary(1)	1						TAAGAGACCAACAGAATCCAA	0.259													G	67561965	G	G	67561965	3	3	6	1	0	0	0	0	1	0	0	0	2001	43	2	4	828	4	C1orf141	1	67561965	Missense_Mutation	SNP	A	TCGA-02-2483-01A-01D-1494-08	38761853	67561965	181688656	2	356											
WDR63	126820	broad.mit.edu	37	chr1	85551548	85551548	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttctcgaaaacgaagtgaatTtggtgcaccaattaagttca	8	7	2	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:85551548T>A	uc001dkt.2	+	7	766	c.575T>A	c.(574-576)TTT>TAT	p.F192Y	WDR63_uc009wcl.2_Missense_Mutation_p.F192Y	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	192										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		CGAAGTGAATTTGGTGCACCA	0.313													A	85551548	A	A	85551548	3	1	6	1	0	0	0	0	1	0	0	0	17311	1841	64	5	597	5	WDR63	1	85551548	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08	17989583	85551548	163699073	3	357											
PGLYRP4	57115	broad.mit.edu	37	chr1	153313050	153313050	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agaccgtgggacaacgccggGgcaagctgaggtggggcgag	20	9	0	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:153313050G>C	uc001fbo.2	-	7	696	c.631C>G	c.(631-633)CCC>GCC	p.P211A	PGLYRP4_uc001fbp.2_Missense_Mutation_p.P207A	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta	211					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)|skin(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACAACGCCGGGGCAAGCTGAG	0.587													C	153313050	C	C	153313050	3	2	6	1	0	0	0	0	1	0	0	0	11796	1232	43	5	502	5	PGLYRP4	1	153313050	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	67761502	153313050	95937571	4	358											
KIFAP3	22920	broad.mit.edu	37	chr1	169951166	169951166	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagatttggctagcaatgcaGcacaagagtcatccatggat	10	9	1	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr1:169951166G>A	uc001ggv.2	-	15	2016	c.1745C>T	c.(1744-1746)GCT>GTT	p.A582V	KIFAP3_uc010plx.1_Missense_Mutation_p.A284V	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	582	ARM 4.				blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TAGCAATGCAGCACAAGAGTC	0.343													A	169951166	A	A	169951166	3	1	6	1	0	0	0	0	1	0	0	0	8311	971	34	3	657	3	KIFAP3	1	169951166	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	16638116	169951166	79299455	5	359											
APOB	338	broad.mit.edu	37	chr2	21230155	21230155	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttgatgctctgactgataaaCtcacaaagcacagccaaagg	8	10	2	3	rs141840973		TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:21230155C>G	uc002red.2	-	26	9713	c.9585G>C	c.(9583-9585)GAG>GAC	p.E3195D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3195	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACTGATAAACTCACAAAGCA	0.323													G	21230155	G	G	21230155	3	3	6	1	0	0	0	0	1	0	0	0	785	564	20	5	4122	5	APOB	2	21230155	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08		21230155	221969218	6	360											
APOB	338	broad.mit.edu	37	chr2	21246441	21246441	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agccttggctccgggagcaaTgactccagatgaagatattt	11	9	0	4			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:21246441T>C	uc002red.2	-	17	2688	c.2560A>G	c.(2560-2562)ATT>GTT	p.I854V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	854					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCGGGAGCAATGACTCCAGAT	0.423													C	21246441	C	C	21246441	3	2	6	1	0	0	0	0	1	0	0	0	785	1464	51	4	11183	4	APOB	2	21246441	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08	16286	21246441	221952932	7	361											
SPTBN1	6711	broad.mit.edu	37	chr2	54857158	54857158	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	aaagcccagcaggacaaactCaacacaaggtgagcacgtgg	11	11	1	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:54857158C>A	uc002rxu.2	+	15	3048	c.2799C>A	c.(2797-2799)CTC>CTA	p.L933L	SPTBN1_uc002rxx.2_Silent_p.L920L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	933	Spectrin 7.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGGACAAACTCAACACAAGGT	0.582													A	54857158	A	A	54857158	2	1	6	1	0	0	0	0	0	0	0	1	15118	813	29	5		5	SPTBN1	2	54857158	Silent	SNP	C	TCGA-02-2483-01A-01D-1494-08	33610717	54857158	188342215	8	362											
WDR33	55339	broad.mit.edu	37	chr2	128471476	128471476	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgcctatcagggggaccccTgcagtcctggccaccccgga	12	17	1	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:128471476T>C	uc002tpg.1	-	18	3172	c.2989A>G	c.(2989-2991)AGG>GGG	p.R997G		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	997					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GGGGGACCCCTGCAGTCCTGG	0.647													C	128471476	C	C	128471476	3	2	6	1	0	0	0	0	1	0	0	0	17284	1579	55	4	1041	4	WDR33	2	128471476	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08	73614318	128471476	114727897	9	363											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	6	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	80641636	209113112	34086261	10	364											
CHL1	10752	broad.mit.edu	37	chr3	367748	367748	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaggaaatccagaaccaacGtgagtattgtttcaaacgaa	8	7	1	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:367748G>A	uc003bou.2	+	4	468	c.197_splice	c.e4+1	p.T66_splice	CHL1_uc003bot.2_Splice_Site_p.T66_splice|CHL1_uc003bow.1_Splice_Site_p.T66_splice|CHL1_uc011asi.1_Splice_Site_p.T66_splice	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAGAACCAACGTGAGTATTGT	0.393													A	367748	A	A	367748	5	1	6	1	0	0	0	0	0	0	1	0	3349	1159	40	1	204	1	CHL1	3	367748	Splice_Site	SNP	G	TCGA-02-2483-01A-01D-1494-08		367748	197654682	11	365											
ATP2B2	491	broad.mit.edu	37	chr3	10491052	10491052	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caacaggtgaggttttgaggCgccggcagatggcttcggtg	17	8	0	3	rs149328739		TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:10491052C>T	uc003bvt.2	-	2	615	c.176G>A	c.(175-177)CGC>CAC	p.R59H	ATP2B2_uc003bvv.2_Missense_Mutation_p.R59H|ATP2B2_uc003bvw.2_Missense_Mutation_p.R59H|ATP2B2_uc010hdp.2_Missense_Mutation_p.R59H	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	59	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding	p.R59C(1)		ovary(3)|skin(2)|central_nervous_system(1)	6						GGTTTTGAGGCGCCGGCAGAT	0.562													T	10491052	T	T	10491052	3	4	6	1	0	0	0	0	1	0	0	0	1140	768	27	1	3643	1	ATP2B2	3	10491052	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	10123304	10491052	187531378	12	366											
ZNF385D	79750	broad.mit.edu	37	chr3	21706493	21706493	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggtggacggacaagggccGggagagcaggactctggcat	18	9	1	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:21706493G>A	uc003cce.2	-	2	458	c.50C>T	c.(49-51)CCG>CTG	p.P17L	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	17						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GACAAGGGCCGGGAGAGCAGG	0.517													A	21706493	A	A	21706493	3	1	6	1	0	0	0	0	1	0	0	0	17875	1116	39	2	1165	2	ZNF385D	3	21706493	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	11215441	21706493	176315937	13	367											
TOMM70A	9868	broad.mit.edu	37	chr3	100105109	100105109	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttctcatgggcttttgcaCgtctaaagagagctttcaca	9	10	3	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:100105109C>T	uc003dtw.2	-	3	1010	c.578G>A	c.(577-579)CGT>CAT	p.R193H		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	193	Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						GGCTTTTGCACGTCTAAAGAG	0.323													T	100105109	T	T	100105109	3	4	6	1	0	0	0	0	1	0	0	0	16359	536	19	1	1288	1	TOMM70A	3	100105109	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	78398616	100105109	97917321	14	368											
LRRC31	79782	broad.mit.edu	37	chr3	169572742	169572742	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggaaagatctaatttcctcaGctcacccaaatacctaaaag	5	11	3	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:169572742G>T	uc003fgc.1	-	6	927	c.850C>A	c.(850-852)CTG>ATG	p.L284M	LRRC31_uc010hwp.1_Missense_Mutation_p.L228M	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	284	LRR 3.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			AATTTCCTCAGCTCACCCAAA	0.338													T	169572742	T	T	169572742	3	4	6	1	0	0	0	0	1	0	0	0	8986	962	34	5	824	5	LRRC31	3	169572742	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	69467633	169572742	28449688	15	369											
PLD1	5337	broad.mit.edu	37	chr3	171426553	171426553	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acaaatactaaccaccagtcTgtgataaaaatctcttcatt	3	10	3	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr3:171426553T>C	uc003fhs.2	-	11	1253	c.1137A>G	c.(1135-1137)ACA>ACG	p.T379T	PLD1_uc003fht.2_Silent_p.T379T	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	379					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACCACCAGTCTGTGATAAAAA	0.348													C	171426553	C	C	171426553	2	2	6	1	0	0	0	0	0	0	0	1	12045	1567	55	4		4	PLD1	3	171426553	Silent	SNP	T	TCGA-02-2483-01A-01D-1494-08	1853811	171426553	26595877	16	370											
KCTD8	386617	broad.mit.edu	37	chr4	44176993	44176993	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttgctgatgagggtctgaaaGagttcactgtttctgcgttt	12	6	3	4			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr4:44176993G>T	uc003gwu.2	-	2	1520	c.1236C>A	c.(1234-1236)CTC>CTA	p.L412L		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	412						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						GGGTCTGAAAGAGTTCACTGT	0.438										HNSCC(17;0.042)			T	44176993	T	T	44176993	2	4	6	1	0	0	0	0	0	0	0	1	8115	929	33	5		5	KCTD8	4	44176993	Silent	SNP	G	TCGA-02-2483-01A-01D-1494-08		44176993	146977283	17	371											
ADAMTS3	9508	broad.mit.edu	37	chr4	73175150	73175150	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggtaaatgtccccttcaCggttcggcagtgggaattat	11	9	2	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr4:73175150C>T	uc003hgk.1	-	15	2180	c.2143G>A	c.(2143-2145)GTG>ATG	p.V715M	ADAMTS3_uc003hgl.2_Missense_Mutation_p.V56M	NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	715	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCCCCTTCACGGTTCGGCAG	0.433													T	73175150	T	T	73175150	3	4	6	1	0	0	0	0	1	0	0	0	267	536	19	1	1506	1	ADAMTS3	4	73175150	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	28998157	73175150	117979126	18	372											
UGT3A2	167127	broad.mit.edu	37	chr5	36048994	36048994	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctgagggttcacttacttgTggtactggtttaataggttt	12	5	1	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr5:36048994T>C	uc003jjz.1	-	4	933	c.840A>G	c.(838-840)CCA>CCG	p.P280P	UGT3A2_uc011cos.1_Silent_p.P246P|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	280	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CACTTACTTGTGGTACTGGTT	0.463													C	36048994	C	C	36048994	2	2	6	1	0	0	0	0	0	0	0	1	16961	1683	59	4		4	UGT3A2	5	36048994	Silent	SNP	T	TCGA-02-2483-01A-01D-1494-08		36048994	144866266	19	373											
NNT	23530	broad.mit.edu	37	chr5	43653189	43653189	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctccacccagggaacagcaCgtcttggcaatgcactgggc	11	14	2	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr5:43653189C>A	uc003joe.2	+	14	2188	c.1933C>A	c.(1933-1935)CGT>AGT	p.R645S	NNT_uc003jof.2_Missense_Mutation_p.R645S	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	645					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	GGGAACAGCACGTCTTGGCAA	0.542													A	43653189	A	A	43653189	3	1	6	1	0	0	0	0	1	0	0	0	10510	536	19	5	1983	5	NNT	5	43653189	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	7604195	43653189	137262071	20	374											
GFRAL	389400	broad.mit.edu	37	chr6	55223736	55223736	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctggcagcgtgtgactagaaAgtgccatgaagatgagaatt	13	6	0	5			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr6:55223736A>T	uc003pcm.1	+	6	838	c.752A>T	c.(751-753)AAG>ATG	p.K251M		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	251	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GTGACTAGAAAGTGCCATGAA	0.393													T	55223736	T	T	55223736	3	4	6	1	0	0	0	0	1	0	0	0	6351	72	3	5	774	5	GFRAL	6	55223736	Missense_Mutation	SNP	A	TCGA-02-2483-01A-01D-1494-08		55223736	115891331	21	375											
CCDC146	57639	broad.mit.edu	37	chr7	76883866	76883866	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tagtaaaagaatttgagaagAtaacaaagccaggagtaagt	10	3	0	3			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:76883866A>T	uc003uga.2	+	5	620	c.493A>T	c.(493-495)ATA>TTA	p.I165L		NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	165										ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				ATTTGAGAAGATAACAAAGCC	0.279													T	76883866	T	T	76883866	3	4	6	1	0	0	0	0	1	0	0	0	2780	333	12	5	507	5	CCDC146	7	76883866	Missense_Mutation	SNP	A	TCGA-02-2483-01A-01D-1494-08		76883866	82254797	22	376											
SEMA3C	10512	broad.mit.edu	37	chr7	80387714	80387714	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcaataagggtcccgcgccaGgcagcagtcagcacaggctg	14	13	1	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:80387714G>C	uc003uhj.2	-	15	2138	c.1576C>G	c.(1576-1578)CTG>GTG	p.L526V	SEMA3C_uc011kgw.1_Missense_Mutation_p.L544V	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	526					immune response|response to drug	membrane	receptor activity			ovary(1)	1						TCCCGCGCCAGGCAGCAGTCA	0.522													C	80387714	C	C	80387714	3	2	6	1	0	0	0	0	1	0	0	0	14026	991	35	5	695	5	SEMA3C	7	80387714	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	3503848	80387714	78750949	23	377											
PCLO	27445	broad.mit.edu	37	chr7	82532013	82532013	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgttatttttatccttgcGtgaggaaagatgtagtgcat	10	5	0	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:82532013G>A	uc003uhx.2	-	9	13771	c.13482C>T	c.(13480-13482)CAC>CAT	p.H4494H	PCLO_uc003uhv.2_Silent_p.H4494H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4425					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTATCCTTGCGTGAGGAAAGA	0.284													A	82532013	A	A	82532013	2	1	6	1	0	0	0	0	0	0	0	1	11583	1136	40	1		1	PCLO	7	82532013	Silent	SNP	G	TCGA-02-2483-01A-01D-1494-08	2144299	82532013	76606650	24	378											
FIS1	51024	broad.mit.edu	37	chr7	100884131	100884131	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgagccggtagttccccaCggccaggtagaagacgtaat	12	11	0	3			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:100884131C>T	uc003uyj.3	-	3	321	c.235G>A	c.(235-237)GTG>ATG	p.V79M	CLDN15_uc003uyh.1_5'Flank|FIS1_uc010lht.2_RNA|FIS1_uc010lhu.2_RNA	NM_016068	NP_057152	Q9Y3D6	FIS1_HUMAN	tetratricopeptide repeat domain 11	79	TPR.|Cytoplasmic (Potential).				apoptosis|mitochondrial fission|peroxisome fission	integral to mitochondrial outer membrane|integral to peroxisomal membrane	protein binding				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TAGTTCCCCACGGCCAGGTAG	0.602													T	100884131	T	T	100884131	3	4	6	1	0	0	0	0	1	0	0	0	5897	536	19	1	235	1	FIS1	7	100884131	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	18352118	100884131	58254532	25	379											
HIPK2	28996	broad.mit.edu	37	chr7	139281490	139281490	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggcgtgtttctgttcctccTcctcgtccgtgtcactgctg	11	14	2	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:139281490T>C	uc003vvf.3	-	12	2864	c.2690A>G	c.(2689-2691)GAG>GGG	p.E897G	HIPK2_uc003vvd.3_Missense_Mutation_p.E870G	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	897	Interaction with TP53 and TP73.|Required for localization to nuclear speckles (By similarity).|Interaction with UBE2I (By similarity).|SUMO interaction motifs (SIM); required for nuclear localization and kinase activity.|Interaction with HMGA1 (By similarity).|Interaction with POU4F1 (By similarity).			DTDEEEE->NFNQQQQ: Loss of SUMO and CBX4 interaction, and impaired nuclear and PML-nuclear bodies localization.	apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					CTGTTCCTCCTCCTCGTCCGT	0.602													C	139281490	C	C	139281490	3	2	6	1	0	0	0	0	1	0	0	0	7117	1551	54	4	922	4	HIPK2	7	139281490	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08	38397359	139281490	19857173	26	380											
TRPV6	55503	broad.mit.edu	37	chr7	142571454	142571454	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctcggggtcctctgtctggAagatgatatagaaggctgct	13	9	2	3			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr7:142571454A>G	uc003wbx.1	-	13	1751	c.1535T>C	c.(1534-1536)TTC>TCC	p.F512S	TRPV6_uc003wbw.1_Missense_Mutation_p.F298S|TRPV6_uc010lou.1_Missense_Mutation_p.F383S	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	512	Helical; (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CTCTGTCTGGAAGATGATATA	0.597													G	142571454	G	G	142571454	3	3	6	1	0	0	0	0	1	0	0	0	16597	246	9	4	654	4	TRPV6	7	142571454	Missense_Mutation	SNP	A	TCGA-02-2483-01A-01D-1494-08	3289964	142571454	16567209	27	381											
SLCO5A1	81796	broad.mit.edu	37	chr8	70594552	70594552	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgttgcagcttcctgtcagaTtcctatggggcatggtgaga	13	9	1	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:70594552T>C	uc003xyl.2	-	7	2356	c.1649A>G	c.(1648-1650)AAT>AGT	p.N550S	SLCO5A1_uc010lzb.2_Missense_Mutation_p.N495S|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.N550S	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	550	Extracellular (Potential).|Kazal-like.					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TCCTGTCAGATTCCTATGGGG	0.403													C	70594552	C	C	70594552	3	2	6	1	0	0	0	0	1	0	0	0	14731	1493	52	4	913	4	SLCO5A1	8	70594552	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08		70594552	75769470	28	382											
FBXO43	286151	broad.mit.edu	37	chr8	101153144	101153144	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttttcatgaacagctcatgTaccaattgcaaggctggggt	10	9	2	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:101153144T>G	uc003yjd.2	-	2	2051	c.1338A>C	c.(1336-1338)GTA>GTC	p.V446V	FBXO43_uc003yje.2_Silent_p.V412V|FBXO43_uc010mbp.1_Silent_p.V446V	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	446					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			ACAGCTCATGTACCAATTGCA	0.433													G	101153144	G	G	101153144	2	3	6	1	0	0	0	0	0	0	0	1	5752	1625	57	5		5	FBXO43	8	101153144	Silent	SNP	T	TCGA-02-2483-01A-01D-1494-08	30558592	101153144	45210878	29	383											
FZD6	8323	broad.mit.edu	37	chr8	104337555	104337555	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caacatgatggccggaaccaAgaaaaactaaagaaatttat	7	7	0	3			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:104337555A>G	uc003ylh.2	+	4	1505	c.1221A>G	c.(1219-1221)CAA>CAG	p.Q407Q	FZD6_uc003yli.2_Silent_p.Q407Q|FZD6_uc003ylj.2_Silent_p.Q407Q|FZD6_uc011lhn.1_Silent_p.Q373Q|FZD6_uc011lho.1_Silent_p.Q102Q|FZD6_uc011lhp.1_Silent_p.Q352Q	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	407	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			GCCGGAACCAAGAAAAACTAA	0.408													G	104337555	G	G	104337555	2	3	6	1	0	0	0	0	0	0	0	1	6134	69	3	4		4	FZD6	8	104337555	Silent	SNP	A	TCGA-02-2483-01A-01D-1494-08	3184411	104337555	42026467	30	384											
TTC35	9694	broad.mit.edu	37	chr8	109468130	109468130	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgctatacagctatatgatAggattttacaagaagatcca	7	6	0	3			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:109468130A>G	uc003ymw.1	+	5	369	c.334A>G	c.(334-336)AGG>GGG	p.R112G		NM_014673	NP_055488	Q15006	TTC35_HUMAN	tetratricopeptide repeat domain 35	112	TPR 1.					endoplasmic reticulum|nucleus	binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.34e-10)			GCTATATGATAGGATTTTACA	0.234													G	109468130	G	G	109468130	3	3	6	1	0	0	0	0	1	0	0	0	16700	411	15	4	352	4	TTC35	8	109468130	Missense_Mutation	SNP	A	TCGA-02-2483-01A-01D-1494-08	5130575	109468130	36895892	31	385											
TAF2	6873	broad.mit.edu	37	chr8	120744252	120744252	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtccttttctttactgtcaTgcttatgcttgtgtttgtgc	8	8	2	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr8:120744252T>C	uc003you.2	-	26	3782	c.3512A>G	c.(3511-3513)CAT>CGT	p.H1171R		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	1171	Lys-rich.|His-rich.				G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTTACTGTCATGCTTATGCTT	0.458													C	120744252	C	C	120744252	3	2	6	1	0	0	0	0	1	0	0	0	15521	1464	51	4	91	4	TAF2	8	120744252	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08	11276122	120744252	25619770	32	386											
SLC35D2	11046	broad.mit.edu	37	chr9	99084300	99084300	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaatatttaaccctacaaaGtttaacaaagagaaaatgta	4	6	0	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr9:99084300G>A	uc004awc.2	-	11	970	c.894C>T	c.(892-894)AAC>AAT	p.N298N	SLC35D2_uc010msd.2_RNA|SLC35D2_uc010mse.2_Silent_p.N251N|SLC35D2_uc010msf.2_Silent_p.N210N|SLC35D2_uc004awd.2_Missense_Mutation_p.L141F	NM_007001	NP_008932	Q76EJ3	S35D2_HUMAN	solute carrier family 35, member D2	298	Helical; (Potential).					Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity				0		Acute lymphoblastic leukemia(62;0.0167)				ACCCTACAAAGTTTAACAAAG	0.343													A	99084300	A	A	99084300	2	1	6	1	0	0	0	0	0	0	0	1	14582	1020	36	3		3	SLC35D2	9	99084300	Silent	SNP	G	TCGA-02-2483-01A-01D-1494-08		99084300	42129131	33	387											
RALGDS	5900	broad.mit.edu	37	chr9	135983521	135983521	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggtgctggagctggctccaGctctagagtttgtgagggag	17	7	1	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr9:135983521G>T	uc004cco.2	-	6	1071	c.1051C>A	c.(1051-1053)CTG>ATG	p.L351M	RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.L339M|RALGDS_uc004ccr.2_Missense_Mutation_p.L350M|RALGDS_uc011mcv.1_Missense_Mutation_p.L322M|RALGDS_uc004ccs.2_Missense_Mutation_p.L296M|RALGDS_uc011mcw.1_Missense_Mutation_p.L422M|RALGDS_uc004ccv.1_Missense_Mutation_p.L120M|RALGDS_uc004ccu.1_Missense_Mutation_p.L120M	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	351					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		GCTGGCTCCAGCTCTAGAGTT	0.582			T	CIITA	PMBL|Hodgkin Lymphona|								T	135983521	T	T	135983521	3	4	6	1	0	0	0	0	1	0	0	0	13016	962	34	5	1745	5	RALGDS	9	135983521	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	36899221	135983521	5229910	34	388											
ANKRD26	22852	broad.mit.edu	37	chr10	27350076	27350076	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcattttttttccatacccaTgtgggctactggcatgccta	8	11	0	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr10:27350076T>C	uc001ith.2	-	13	1631	c.1459A>G	c.(1459-1461)ATG>GTG	p.M487V	ANKRD26_uc001itg.2_Intron|ANKRD26_uc009xku.1_Missense_Mutation_p.M487V	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	487						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TCCATACCCATGTGGGCTACT	0.348													C	27350076	C	C	27350076	3	2	6	1	0	0	0	0	1	0	0	0	654	1464	51	4	3761	4	ANKRD26	10	27350076	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08		27350076	108184671	35	389											
MPP7	143098	broad.mit.edu	37	chr10	28409253	28409254	+	Missense_Mutation	DNP	CA	AG	AG													tccctttttgaaagaaagccCagcttccttacatggaattg							TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr10:28409253_28409254CA>AG	uc001iua.1	-	12	1160_1161	c.756_757TG>CT	c.(754-759)GCTGGG>GCCTGG	p.G253W	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Missense_Mutation_p.G253W|MPP7_uc009xla.2_Missense_Mutation_p.G253W|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	253	SH3.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						AAAGAAAGCCCAGCTTCCTTAC	0.406													AG	28409254	AG	AG	28409253	3	1	6	1	0	0	0	0	1	0	0	0	9739	594	21	5	1005	5	MPP7	10	28409253	Missense_Mutation	DNP	CA	TCGA-02-2483-01A-01D-1494-08	1059177	28409253	107125494	36	390											
BMS1	9790	broad.mit.edu	37	chr10	43316067	43316067	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tcccactgtattatatcgaaGaccacaatggaagacaaagg	8	9	0	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr10:43316067G>C	uc001jaj.2	+	17	3239	c.2881G>C	c.(2881-2883)GAC>CAC	p.D961H		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	961					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TTATATCGAAGACCACAATGG	0.428													C	43316067	C	C	43316067	3	2	6	1	0	0	0	0	1	0	0	0	1472	942	33	5	2943	5	BMS1	10	43316067	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	14906814	43316067	92218680	37	391											
BICC1	80114	broad.mit.edu	37	chr10	60553292	60553292	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atatgaaggaagaaattgaaGtagatccacaattcattgcg	9	5	1	4			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr10:60553292G>A	uc001jki.1	+	9	1096	c.1096G>A	c.(1096-1098)GTA>ATA	p.V366I	BICC1_uc001jkj.1_Missense_Mutation_p.V7I	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	366					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						AGAAATTGAAGTAGATCCACA	0.368													A	60553292	A	A	60553292	3	1	6	1	0	0	0	0	1	0	0	0	1427	1029	36	3	1130	3	BICC1	10	60553292	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	17237225	60553292	74981455	38	392											
OR5L1	219437	broad.mit.edu	37	chr11	55579759	55579759	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atagtggagatgctgacaaaGtggccaccgtgttctacaca	11	9	1	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr11:55579759G>T	uc001nhw.1	+	1	817	c.817G>T	c.(817-819)GTG>TTG	p.V273L		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TGCTGACAAAGTGGCCACCGT	0.473													T	55579759	T	T	55579759	3	4	6	1	0	0	0	0	1	0	0	0	11170	1029	36	5	819	5	OR5L1	11	55579759	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08		55579759	79426757	39	393											
OR5B12	390191	broad.mit.edu	37	chr11	58207194	58207194	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaccacagatgtaggagcctAtggccaggcaagcacataca	10	11	0	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr11:58207194A>G	uc010rkh.1	-	1	431	c.431T>C	c.(430-432)ATA>ACA	p.I144T		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTAGGAGCCTATGGCCAGGCA	0.463													G	58207194	G	G	58207194	3	3	6	1	0	0	0	0	1	0	0	0	11148	449	16	4	517	4	OR5B12	11	58207194	Missense_Mutation	SNP	A	TCGA-02-2483-01A-01D-1494-08	2627435	58207194	76799322	40	394											
IGHMBP2	3508	broad.mit.edu	37	chr11	68704092	68704092	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagcccagcctcaacggagGcagcccagagggagtggaga	15	12	2	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr11:68704092G>A	uc001ook.1	+	13	2246	c.2144G>A	c.(2143-2145)GGC>GAC	p.G715D	IGHMBP2_uc001ool.1_Missense_Mutation_p.G339D|IGHMBP2_uc001oom.1_Missense_Mutation_p.G293D	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	715	SS DNA-binding (By similarity).				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTCAACGGAGGCAGCCCAGAG	0.617													A	68704092	A	A	68704092	3	1	6	1	0	0	0	0	1	0	0	0	7591	1203	42	3	2194	3	IGHMBP2	11	68704092	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	10496898	68704092	66302424	41	395											
TMEM133	83935	broad.mit.edu	37	chr11	100863381	100863381	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atccccctgcttcaaaatgtGccagttccacttggtaataa	6	12	1	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr11:100863381G>T	uc001pgf.2	+	1	571	c.342G>T	c.(340-342)GTG>GTT	p.V114V		NM_032021	NP_114410	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	114	Helical; (Potential).					integral to membrane					0		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		TTCAAAATGTGCCAGTTCCAC	0.373													T	100863381	T	T	100863381	2	4	6	1	0	0	0	0	0	0	0	1	16046	1306	46	5		5	TMEM133	11	100863381	Silent	SNP	G	TCGA-02-2483-01A-01D-1494-08	32159289	100863381	34143135	42	396											
TAS2R9	50835	broad.mit.edu	37	chr12	10962585	10962585	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttgagccagtcaatgcagttAactagtacaatgaatccatt	7	8	1	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr12:10962585A>T	uc001qyx.2	-	1	183	c.90T>A	c.(88-90)GTT>GTA	p.V30V		NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	30	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						CAATGCAGTTAACTAGTACAA	0.388													T	10962585	T	T	10962585	2	4	6	1	0	0	0	0	0	0	0	1	15585	349	13	5		5	TAS2R9	12	10962585	Silent	SNP	A	TCGA-02-2483-01A-01D-1494-08		10962585	122889310	43	397											
BIN2	51411	broad.mit.edu	37	chr12	51685543	51685543	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcccagtccccaaggaggcCctagggctggtgggtgaacc	15	13	0	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr12:51685543C>T	uc001ryg.2	-	10	1399	c.1347G>A	c.(1345-1347)AGG>AGA	p.R449R	BIN2_uc009zlz.2_Silent_p.R417R|BIN2_uc001ryh.2_Silent_p.R325R|BIN2_uc010sng.1_Silent_p.R423R	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	449	Pro-rich.					cytoplasm	protein binding			ovary(1)	1						CCAAGGAGGCCCTAGGGCTGG	0.612													T	51685543	T	T	51685543	2	4	6	1	0	0	0	0	0	0	0	1	1433	622	22	3		3	BIN2	12	51685543	Silent	SNP	C	TCGA-02-2483-01A-01D-1494-08	40722958	51685543	82166352	44	398											
R3HDM2	22864	broad.mit.edu	37	chr12	57648757	57648757	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtcccactgttgtcccccccAccccctccaggcagcccctg	7	23	0	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr12:57648757A>C	uc009zpm.1	-	22	2765	c.2730T>G	c.(2728-2730)GGT>GGG	p.G910G	R3HDM2_uc010srn.1_Intron|R3HDM2_uc001snu.2_Silent_p.G605G|R3HDM2_uc001snr.2_Silent_p.G637G|R3HDM2_uc001sns.2_Silent_p.G910G|R3HDM2_uc001snt.2_Silent_p.G924G|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	910	Poly-Gly.					nucleus	nucleic acid binding			ovary(2)	2						TGTCCCCCCCACCCCCTCCAG	0.632													C	57648757	C	C	57648757	2	2	6	1	0	0	0	0	0	0	0	1	12888	146	6	5		5	R3HDM2	12	57648757	Silent	SNP	A	TCGA-02-2483-01A-01D-1494-08	5963214	57648757	76203138	45	399											
IRAK3	11213	broad.mit.edu	37	chr12	66638935	66638935	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tggattcatgtctctcatttCtagataagaaagtgcctccc	7	10	4	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr12:66638935C>A	uc001sth.2	+	11	1309	c.1207C>A	c.(1207-1209)CTA>ATA	p.L403I	IRAK3_uc010ssy.1_Missense_Mutation_p.L342I	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	403	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		TCTCTCATTTCTAGATAAGAA	0.478													A	66638935	A	A	66638935	3	1	6	1	0	0	0	0	1	0	0	0	7824	912	32	5	1249	5	IRAK3	12	66638935	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	8990178	66638935	67212960	46	400											
ATP11A	23250	broad.mit.edu	37	chr13	113510350	113510350	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcctggaaatctgccggaGctgcagcgcggtgctctgct	13	13	2	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr13:113510350G>A	uc001vsi.3	+	20	2457	c.2369G>A	c.(2368-2370)AGC>AAC	p.S790N	ATP11A_uc001vsj.3_Missense_Mutation_p.S790N|ATP11A_uc001vsm.1_Missense_Mutation_p.S666N|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	790	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				ATCTGCCGGAGCTGCAGCGCG	0.597													A	113510350	A	A	113510350	3	1	6	1	0	0	0	0	1	0	0	0	1119	971	34	3	2447	3	ATP11A	13	113510350	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08		113510350	1659528	47	401											
DCAF11	80344	broad.mit.edu	37	chr14	24588926	24588926	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccttttcgcctagattgagTcccatgaggatgatgtgaat	10	8	0	5			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr14:24588926T>C	uc001wlv.2	+	11	1193	c.913T>C	c.(913-915)TCC>CCC	p.S305P	DCAF11_uc001wlw.2_Missense_Mutation_p.S305P|DCAF11_uc001wlz.2_Missense_Mutation_p.S205P|DCAF11_uc001wly.2_Missense_Mutation_p.S261P|DCAF11_uc001wme.2_Missense_Mutation_p.S265P|DCAF11_uc010tny.1_Missense_Mutation_p.S172P|DCAF11_uc001wmd.2_Missense_Mutation_p.S305P|DCAF11_uc001wmc.2_Missense_Mutation_p.S205P|DCAF11_uc001wmb.3_Missense_Mutation_p.S279P|DCAF11_uc001wma.3_Missense_Mutation_p.S305P	NM_001163484	NP_001156956	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11 isoform 1	305	WD 4.					CUL4 RING ubiquitin ligase complex	protein binding				0						CTAGATTGAGTCCCATGAGGA	0.483													C	24588926	C	C	24588926	3	2	6	1	0	0	0	0	1	0	0	0	4262	1667	58	4	951	4	DCAF11	14	24588926	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08		24588926	82760614	48	402											
GRAMD2	196996	broad.mit.edu	37	chr15	72460907	72460907	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttgtatttattcagtgttaTctgcaaacacacaggctgcg	9	8	2	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr15:72460907T>C	uc002atq.2	-	4	217	c.193A>G	c.(193-195)ATA>GTA	p.I65V	GRAMD2_uc010bis.2_Missense_Mutation_p.I65V	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	65						integral to membrane					0						TTCAGTGTTATCTGCAAACAC	0.542													C	72460907	C	C	72460907	3	2	6	1	0	0	0	0	1	0	0	0	6750	1449	50	4	907	4	GRAMD2	15	72460907	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08		72460907	30070485	49	403											
IDH3A	3419	broad.mit.edu	37	chr15	78454015	78454015	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acgcgaatgtccgaccatgtGtctctatcgaaggctataaa	9	10	1	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr15:78454015G>T	uc002bdd.2	+	5	409	c.382G>T	c.(382-384)GTC>TTC	p.V128F	IDH3A_uc010umt.1_Intron|IDH3A_uc010umu.1_Missense_Mutation_p.V19F|IDH3A_uc002bde.2_Missense_Mutation_p.V78F|IDH3A_uc010umv.1_Missense_Mutation_p.V78F|IDH3A_uc002bdf.2_5'UTR|IDH3A_uc002bdg.2_Missense_Mutation_p.V41F	NM_005530	NP_005521	P50213	IDH3A_HUMAN	isocitrate dehydrogenase 3 (NAD+) alpha	128					carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	CCGACCATGTGTCTCTATCGA	0.443													T	78454015	T	T	78454015	3	4	6	1	0	0	0	0	1	0	0	0	7496	1377	48	5	400	5	IDH3A	15	78454015	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	5993108	78454015	24077377	50	404											
PARN	5073	broad.mit.edu	37	chr16	14704541	14704541	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttttgatcctcaggaatcgTgacaggacattttgaagtgt	10	7	1	3			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr16:14704541T>C	uc010uzd.1	-	7	656	c.514A>G	c.(514-516)ACG>GCG	p.T172A	PARN_uc010uzc.1_Missense_Mutation_p.T111A|PARN_uc010uze.1_Missense_Mutation_p.T126A|PARN_uc010uzf.1_Intron|PARN_uc010uzg.1_RNA	NM_002582	NP_002573	O95453	PARN_HUMAN	poly(A)-specific ribonuclease (deadenylation	172					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2						TCAGGAATCGTGACAGGACAT	0.408													C	14704541	C	C	14704541	3	2	6	1	0	0	0	0	1	0	0	0	11453	1696	59	4	1477	4	PARN	16	14704541	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08		14704541	75650212	51	405											
ZNF646	9726	broad.mit.edu	37	chr16	31087887	31087887	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcccctgtaccacctgtgGcaaggacttctccaatccca	6	16	1	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr16:31087887G>A	uc002eap.2	+	2	531	c.242G>A	c.(241-243)GGC>GAC	p.G81D	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	81	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						ACCACCTGTGGCAAGGACTTC	0.627													A	31087887	A	A	31087887	3	1	6	1	0	0	0	0	1	0	0	0	18059	1203	42	3	244	3	ZNF646	16	31087887	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	16383346	31087887	59266866	52	406											
NXN	64359	broad.mit.edu	37	chr17	722696	722696	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taccttggattccgtacagcCggttgaggcgcgaccgccgg	14	13	0	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:722696C>T	uc002fsa.2	-	5	895	c.803G>A	c.(802-804)CGG>CAG	p.R268Q	NXN_uc002fsb.1_Missense_Mutation_p.R155Q|NXN_uc010vqd.1_Missense_Mutation_p.R19Q|NXN_uc002frz.2_Missense_Mutation_p.R19Q|NXN_uc010vqe.1_Missense_Mutation_p.R160Q	NM_022463	NP_071908	Q6DKJ4	NXN_HUMAN	nucleoredoxin	268	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			ovary(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		TCCGTACAGCCGGTTGAGGCG	0.607													T	722696	T	T	722696	3	4	6	1	0	0	0	0	1	0	0	0	10787	652	23	2	520	2	NXN	17	722696	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08		722696	80472514	53	407											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	8	15	1	0	rs28934576	by1000genomes	TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577120	T	T	7577120	3	4	6	1	0	0	0	0	1	0	0	0	16378	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	6854424	7577120	73618090	54	408											
KRT9	3857	broad.mit.edu	37	chr17	39727935	39727935	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccccagaactactatagcCtcctccagaagcaccaccaa	4	18	0	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:39727935C>T	uc002hxe.3	-	1	376	c.310G>A	c.(310-312)GGC>AGC	p.G104S	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	104	Head.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				ctactatagcctcctccagaa	0.129													T	39727935	T	T	39727935	3	4	6	1	0	0	0	0	1	0	0	0	8501	681	24	3	1589	3	KRT9	17	39727935	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	32150815	39727935	41467275	55	409											
ABCA9	10350	broad.mit.edu	37	chr17	67012462	67012462	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aattccaagtagtccattgcTaatgacatccaggaggacag	9	9	0	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:67012462T>C	uc002jhu.2	-	22	3114	c.2971A>G	c.(2971-2973)AGC>GGC	p.S991G	ABCA9_uc010dez.2_Missense_Mutation_p.S991G	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	991					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					AGTCCATTGCTAATGACATCC	0.348													C	67012462	C	C	67012462	3	2	6	1	0	0	0	0	1	0	0	0	39	1522	53	4	1975	4	ABCA9	17	67012462	Missense_Mutation	SNP	T	TCGA-02-2483-01A-01D-1494-08	27284527	67012462	14182748	56	410											
RECQL5	9400	broad.mit.edu	37	chr17	73627684	73627684	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgtggggttctggcagtggtCgcagcctttggcgcaggcag	18	10	1	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr17:73627684C>T	uc010dgl.2	-	9	1450	c.1294G>A	c.(1294-1296)GAC>AAC	p.D432N	RECQL5_uc010dgk.2_Missense_Mutation_p.D405N|RECQL5_uc002jot.3_5'Flank|LOC643008_uc002jow.2_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	432					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TGGCAGTGGTCGCAGCCTTTG	0.701								Other_identified_genes_with_known_or_suspected_DNA_repair_function					T	73627684	T	T	73627684	3	4	6	1	0	0	0	0	1	0	0	0	13203	884	31	2	1729	2	RECQL5	17	73627684	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	6615222	73627684	7567526	57	411											
NDUFV2	4729	broad.mit.edu	37	chr18	9124948	9124948	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtttaggggcctgtgtgaaCgcaccaatggttcaaataaa	11	7	1	1	rs143576401	byFrequency	TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr18:9124948C>T	uc002knu.2	+	6	613	c.546C>T	c.(544-546)AAC>AAT	p.N182N		NM_021074	NP_066552	P19404	NDUV2_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 2	182					cardiac muscle tissue development|mitochondrial electron transport, NADH to ubiquinone|nervous system development|transport	mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			ovary(1)	1					NADH(DB00157)	CCTGTGTGAACGCACCAATGG	0.313													T	9124948	T	T	9124948	2	4	6	1	0	0	0	0	0	0	0	1	10300	535	19	1		1	NDUFV2	18	9124948	Silent	SNP	C	TCGA-02-2483-01A-01D-1494-08		9124948	68952300	58	412											
GRIN3B	116444	broad.mit.edu	37	chr19	1004870	1004870	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caacgactcggccaccctggAcgcactgttcgccgcgctgg	12	17	0	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:1004870A>G	uc002lqo.1	+	3	1370	c.1370A>G	c.(1369-1371)GAC>GGC	p.D457G		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	457	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GCCACCCTGGACGCACTGTTC	0.672													G	1004870	G	G	1004870	3	3	6	1	0	0	0	0	1	0	0	0	6784	275	10	4	1380	4	GRIN3B	19	1004870	Missense_Mutation	SNP	A	TCGA-02-2483-01A-01D-1494-08		1004870	58124113	59	413											
PTPRS	5802	broad.mit.edu	37	chr19	5211663	5211663	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccacaccccggatgggttgCagacagacccgtgtgctctc	11	15	1	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:5211663C>T	uc002mbv.2	-	33	5406	c.5172G>A	c.(5170-5172)CTG>CTA	p.L1724L	PTPRS_uc002mbu.1_Silent_p.L1293L|PTPRS_uc010xin.1_Silent_p.L1266L|PTPRS_uc002mbw.2_Silent_p.L1686L|PTPRS_uc002mbx.2_Silent_p.L1281L|PTPRS_uc002mby.2_Silent_p.L1277L	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1724	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGATGGGTTGCAGACAGACCC	0.552													T	5211663	T	T	5211663	2	4	6	1	0	0	0	0	0	0	0	1	12811	697	25	3		3	PTPRS	19	5211663	Silent	SNP	C	TCGA-02-2483-01A-01D-1494-08	4206793	5211663	53917320	60	414											
C3	718	broad.mit.edu	37	chr19	6711035	6711035	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatcttggcctcgtgggcgCggtccattcgcaggaggaag	17	10	1	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:6711035C>T	uc002mfm.2	-	12	1504	c.1442G>A	c.(1441-1443)CGC>CAC	p.R481H		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	481					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTCGTGGGCGCGGTCCATTCG	0.607													T	6711035	T	T	6711035	3	4	6	1	0	0	0	0	1	0	0	0	2204	768	27	1	3669	1	C3	19	6711035	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	1499372	6711035	52417948	61	415											
PDE4C	5143	broad.mit.edu	37	chr19	18331288	18331288	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaggcaccagtccagctcGtctagcgtctccaatgccag	9	16	2	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:18331288G>A	uc010xqc.1	-	6	1113	c.633C>T	c.(631-633)GAC>GAT	p.D211D	PDE4C_uc002nik.3_Silent_p.D211D|PDE4C_uc002nil.3_Silent_p.D211D|PDE4C_uc002nif.3_Translation_Start_Site|PDE4C_uc002nig.3_Intron|PDE4C_uc002nih.3_Intron|PDE4C_uc010ebk.2_Silent_p.D105D|PDE4C_uc002nii.3_Silent_p.D179D|PDE4C_uc010ebl.2_Translation_Start_Site|PDE4C_uc010xqd.1_Translation_Start_Site|PDE4C_uc010ebm.1_RNA|PDE4C_uc002nim.1_Nonsense_Mutation_p.R195*	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	211				D -> Y (in Ref. 2; AAD47053/AAD47054).	signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	AGTCCAGCTCGTCTAGCGTCT	0.672													A	18331288	A	A	18331288	2	1	6	1	0	0	0	0	0	0	0	1	11641	1136	40	1		1	PDE4C	19	18331288	Silent	SNP	G	TCGA-02-2483-01A-01D-1494-08	11620253	18331288	40797695	62	416											
SBSN	374897	broad.mit.edu	37	chr19	36017633	36017633	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccggcctggccagcagcatgGtgggcaccttggccaagctt	14	14	0	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:36017633G>T	uc002oae.1	-	2	592	c.522C>A	c.(520-522)CAC>CAA	p.H174Q	SBSN_uc002oad.1_Missense_Mutation_p.H517Q	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	174	Ala/Gly/His-rich.					extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CAGCAGCATGGTGGGCACCTT	0.582													T	36017633	T	T	36017633	3	4	6	1	0	0	0	0	1	0	0	0	13864	1252	44	5	237	5	SBSN	19	36017633	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	17686345	36017633	23111350	63	417											
ZNF569	148266	broad.mit.edu	37	chr19	37904719	37904719	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atcaataagatttgatttctGgctgaaggacttctcacatt	7	7	3	3			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:37904719G>T	uc002ogi.2	-	6	1399	c.841C>A	c.(841-843)CAG>AAG	p.Q281K	ZNF569_uc002ogh.2_Missense_Mutation_p.Q122K|ZNF569_uc002ogj.2_Missense_Mutation_p.Q305K	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	281	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTGATTTCTGGCTGAAGGAC	0.358													T	37904719	T	T	37904719	3	4	6	1	0	0	0	0	1	0	0	0	17997	1357	47	5	1223	5	ZNF569	19	37904719	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	1887086	37904719	21224264	64	418											
ZNF155	7711	broad.mit.edu	37	chr19	44500816	44500816	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gaggcatgtgggaaggccttCattcatgattcccagcttaa	11	9	2	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:44500816C>A	uc002oxy.1	+	5	1012	c.807C>A	c.(805-807)TTC>TTA	p.F269L	ZNF155_uc002oxz.1_Missense_Mutation_p.F269L|ZNF155_uc010xwt.1_Missense_Mutation_p.F280L	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	269	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				GGAAGGCCTTCATTCATGATT	0.398													A	44500816	A	A	44500816	3	1	6	1	0	0	0	0	1	0	0	0	17733	825	29	5	821	5	ZNF155	19	44500816	Missense_Mutation	SNP	C	TCGA-02-2483-01A-01D-1494-08	6596097	44500816	14628167	65	419											
PNMAL1	55228	broad.mit.edu	37	chr19	46973358	46973359	+	Missense_Mutation	DNP	CA	AT	AT													gtggctctctgggacccttcCaggcacatttcgccatgggc							TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr19:46973358_46973359CA>AT	uc002peq.3	-	2	1240_1241	c.934_935TG>AT	c.(934-936)TGG>ATG	p.W312M	PNMAL1_uc002per.3_Missense_Mutation_p.W312M	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	312											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GGGACCCTTCCAGGCACATTTC	0.584													AT	46973359	AT	AT	46973358	3	1	6	1	0	0	0	0	1	0	0	0	12157	595	21	5	414	5	PNMAL1	19	46973358	Missense_Mutation	DNP	CA	TCGA-02-2483-01A-01D-1494-08	2472542	46973358	12155625	66	420											
COL18A1	80781	broad.mit.edu	37	chr21	46925140	46925141	+	In_Frame_Ins	INS	-	GGCCCCCCA	GGCCCCCCA													aggggcgccagggccctcccINSggccccccaggccccccagg							TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr21:46925140_46925141insGGCCCCCCA	uc011afs.1	+	35	4218_4219	c.4197_4198insGGCCCCCCA	c.(4195-4200)insGGCCCCCCA	p.1408_1409insGPP	COL18A1_uc002zhg.2_In_Frame_Ins_p.993_994insGPP|COL18A1_uc002zhi.2_In_Frame_Ins_p.1173_1174insGPP|SLC19A1_uc010gpy.1_Intron|COL18A1_uc002zhj.2_5'UTR|COL18A1_uc002zhk.2_5'Flank	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1411_1412	Nonhelical region 10 (NC10).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		AGGGCCCTCCCGGCCCCCCAGG	0.733													GGCCCCCCA	46925141	GGCCCCCCA	GGCCCCCCA	46925140	7	5	6	1	0	1	1	0	0	0	0	0	3675	639	23	0	4449	0	COL18A1	21	46925140	In_Frame_Ins	INS	-	TCGA-02-2483-01A-01D-1494-08		46925140	1204755	67	421											
GAS2L1	10634	broad.mit.edu	37	chr22	29707873	29707873	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccccagactccccgtgcccGcagccctgcagcaccccggc	9	24	0	1			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr22:29707873G>A	uc003afa.1	+	7	1632	c.1433G>A	c.(1432-1434)CGC>CAC	p.R478H	GAS2L1_uc010gvm.1_Intron|GAS2L1_uc003afb.1_3'UTR|GAS2L1_uc003afc.1_Missense_Mutation_p.R478H|GAS2L1_uc003afd.1_Missense_Mutation_p.A478T|GAS2L1_uc003afe.1_Missense_Mutation_p.A478T	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	478					cell cycle arrest	cytoplasm|cytoskeleton					0						CCCCGTGCCCGCAGCCCTGCA	0.711													A	29707873	A	A	29707873	3	1	6	1	0	0	0	0	1	0	0	0	6246	1087	38	1	1454	1	GAS2L1	22	29707873	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08		29707873	21596693	68	422											
EP300	2033	broad.mit.edu	37	chr22	41564740	41564740	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tataggtttgtggacagtggAgagatggcagaatcctttcc	13	6	0	2			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chr22:41564740A>G	uc003azl.3	+	25	4436	c.4041A>G	c.(4039-4041)GGA>GGG	p.G1347G		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1347					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGGACAGTGGAGAGATGGCAG	0.433			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				G	41564740	G	G	41564740	2	3	6	1	0	0	0	0	0	0	0	1	5148	291	11	4		4	EP300	22	41564740	Silent	SNP	A	TCGA-02-2483-01A-01D-1494-08	11856867	41564740	9739826	69	423											
ATRX	546	broad.mit.edu	37	chrX	76849273	76849273	+	Frame_Shift_Del	DEL	C	-	-													tctgtaacaaaatctttgtaCcagtctggagctgggctgct							TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chrX:76849273delC	uc004ecp.3	-	26	6235	c.6003delG	c.(6001-6003)TGGfs	p.W2001fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.W1963fs|ATRX_uc004eco.3_Frame_Shift_Del_p.W1786fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2001					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AATCTTTGTACCAGTCTGGAG	0.383			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						-	76849273	-	-	76849273	7	5	6	1	0	1	0	1	0	0	0	0	1208	508	18	0	1515	0	ATRX	23	76849273	Frame_Shift_Del	DEL	C	TCGA-02-2483-01A-01D-1494-08		76849273	78421287	70	424											
AFF2	2334	broad.mit.edu	37	chrX	147733555	147733555	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccgtagtgcacttaaaaaaaGggaatgggagcggaggaatc	14	6	0	0			TCGA-02-2483-01A-01D-1494-08	TCGA-02-2483-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d7f2c74-862b-4aad-98e1-fa831f14a905	f191bb9c-1937-40e5-8491-76dede722cdd	g.chrX:147733555G>T	uc004fcp.2	+	2	562	c.83G>T	c.(82-84)AGG>ATG	p.R28M	AFF2_uc004fco.2_Missense_Mutation_p.R28M|AFF2_uc004fcq.2_Missense_Mutation_p.R28M|AFF2_uc004fcr.2_Missense_Mutation_p.R28M|AFF2_uc011mxb.1_Missense_Mutation_p.R28M|AFF2_uc004fcs.2_Missense_Mutation_p.R28M	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	28					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CTTAAAAAAAGGGAATGGGAG	0.363													T	147733555	T	T	147733555	3	4	6	1	0	0	0	0	1	0	0	0	357	1000	35	5	89	5	AFF2	23	147733555	Missense_Mutation	SNP	G	TCGA-02-2483-01A-01D-1494-08	70884282	147733555	7537005	71	425											
EPHB2	2048	broad.mit.edu	37	chr1	23110979	23110979	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagccagaacaactggctacGgaccaagtttatccggcgcc	10	13	0	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr1:23110979G>A	uc009vqj.1	+	3	366	c.221G>A	c.(220-222)CGG>CAG	p.R74Q	EPHB2_uc001bge.2_Missense_Mutation_p.R74Q|EPHB2_uc001bgf.2_Missense_Mutation_p.R74Q|EPHB2_uc010odu.1_Missense_Mutation_p.R74Q	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	74	Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		AACTGGCTACGGACCAAGTTT	0.587									Hereditary_Prostate_Cancer				A	23110979	A	A	23110979	3	1	7	1	0	0	0	0	1	0	0	0	5175	1116	39	2	231	2	EPHB2	1	23110979	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08		23110979	226139642	1	426											
WNT2B	7482	broad.mit.edu	37	chr1	113059824	113059825	+	Frame_Shift_Del	DEL	CT	-	-													tgcgcacctgctggcgtgcaCtctcagatttccgccgcaca							TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr1:113059824_113059825delCT	uc001ecb.2	+	4	1278_1279	c.763_764delCT	c.(763-765)CTCfs	p.L255fs	WNT2B_uc001eca.2_Frame_Shift_Del_p.L236fs|WNT2B_uc009wgg.2_Frame_Shift_Del_p.L163fs	NM_024494	NP_078613	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family,	255					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			ovary(2)|breast(2)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGGCGTGCACTCTCAGATTTC	0.624													-	113059825	-	-	113059824	7	5	7	1	0	1	0	1	0	0	0	0	17384	565	20	0	910	0	WNT2B	1	113059824	Frame_Shift_Del	DEL	CT	TCGA-02-2485-01A-01D-1494-08	89948845	113059824	136190797	2	427											
FLG	2312	broad.mit.edu	37	chr1	152279764	152279764	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaggaagcttcatggtgaCgcgaccctgagtgcctggag	16	9	1	3			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr1:152279764C>T	uc001ezu.1	-	3	7634	c.7598G>A	c.(7597-7599)CGT>CAT	p.R2533H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2533	Ser-rich.|Filaggrin 15.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCATGGTGACGCGACCCTGA	0.592									Ichthyosis				T	152279764	T	T	152279764	3	4	7	1	0	0	0	0	1	0	0	0	5922	536	19	1	4591	1	FLG	1	152279764	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	39219940	152279764	96970857	3	428											
FNDC4	64838	broad.mit.edu	37	chr2	27716857	27716857	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagagttcggaagtgcacccGgggccctgggggactctctc	16	12	1	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr2:27716857G>A	uc002rkx.2	-	4	800	c.394C>T	c.(394-396)CGG>TGG	p.R132W	GCKR_uc002rky.2_5'Flank|GCKR_uc010ezd.2_5'Flank|GCKR_uc010ylu.1_5'Flank	NM_022823	NP_073734	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	132	Extracellular (Potential).|Fibronectin type-III.					integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					AAGTGCACCCGGGGCCCTGGG	0.607													A	27716857	A	A	27716857	3	1	7	1	0	0	0	0	1	0	0	0	5971	1115	39	2	326	2	FNDC4	2	27716857	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08		27716857	215482516	4	429											
SCN3A	6328	broad.mit.edu	37	chr2	166019327	166019327	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctggatcagggcccccacaaTggtctttaaacctgcagaga	10	12	2	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr2:166019327T>C	uc002ucx.2	-	8	1198	c.706A>G	c.(706-708)ATT>GTT	p.I236V	SCN3A_uc002ucy.2_Missense_Mutation_p.I236V|SCN3A_uc002ucz.2_Missense_Mutation_p.I236V|SCN3A_uc002uda.1_Missense_Mutation_p.I105V|SCN3A_uc002udb.1_Missense_Mutation_p.I105V	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	236						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GCCCCCACAATGGTCTTTAAA	0.453													C	166019327	C	C	166019327	3	2	7	1	0	0	0	0	1	0	0	0	13918	1464	51	4	5380	4	SCN3A	2	166019327	Missense_Mutation	SNP	T	TCGA-02-2485-01A-01D-1494-08	138302470	166019327	77180046	5	430											
ZNF804A	91752	broad.mit.edu	37	chr2	185802513	185802513	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttaccagaagaatttttgaGgccaccaagtacttcagttg	8	8	1	3			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr2:185802513G>A	uc002uph.2	+	4	2984	c.2390G>A	c.(2389-2391)AGG>AAG	p.R797K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	797						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAATTTTTGAGGCCACCAAGT	0.383													A	185802513	A	A	185802513	3	1	7	1	0	0	0	0	1	0	0	0	18167	1000	35	3	2404	3	ZNF804A	2	185802513	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	19783186	185802513	57396860	6	431											
ANKRD44	91526	broad.mit.edu	37	chr2	197863059	197863059	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tattttaaattcatttacatActttactacaagccaaatgt	2	7	1	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr2:197863059A>G	uc002uua.1	-	25	2750	c.2673_splice	c.e25+1	p.K891_splice	ANKRD44_uc002utz.3_Splice_Site_p.K623_splice	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44								protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCATTTACATACTTTACTACA	0.333													G	197863059	G	G	197863059	5	3	7	1	0	0	0	0	0	0	1	0	672	405	14	4	92	4	ANKRD44	2	197863059	Splice_Site	SNP	A	TCGA-02-2485-01A-01D-1494-08	12060546	197863059	45336314	7	432											
KIAA1486	57624	broad.mit.edu	37	chr2	226446958	226446958	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gaggaaatgaagtaccctatCtttgacgacttgggccaaga	11	8	1	3			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr2:226446958C>A	uc002voe.2	+	4	1000	c.825C>A	c.(823-825)ATC>ATA	p.I275I	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Silent_p.I45I	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	275										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		AGTACCCTATCTTTGACGACT	0.542													A	226446958	A	A	226446958	2	1	7	1	0	0	0	0	0	0	0	1	8237	903	32	5		5	KIAA1486	2	226446958	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08	28583899	226446958	16752415	8	433			1	2		2	2	22	C		5.155449e-05
KIAA1486	57624	broad.mit.edu	37	chr2	226446979	226446979	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgacgacttgggccaagaCgccaaatgtgacttcgacca	10	11	0	3			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr2:226446979C>T	uc002voe.2	+	4	1021	c.846C>T	c.(844-846)GAC>GAT	p.D282D	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Silent_p.D52D	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	282										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		TGGGCCAAGACGCCAAATGTG	0.557													T	226446979	T	T	226446979	2	4	7	1	0	0	0	0	0	0	0	1	8237	535	19	1		1	KIAA1486	2	226446979	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08	21	226446979	16752394	9	434			1	2		2	2	22	C		5.155449e-05
COL6A3	1293	broad.mit.edu	37	chr2	238249201	238249201	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acgtcgtttggctcactggcGaaggtgtatacctccttgat	11	10	1	1	rs113423040		TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr2:238249201G>A	uc002vwl.2	-	38	8643	c.8358C>T	c.(8356-8358)TTC>TTT	p.F2786F	COL6A3_uc002vwo.2_Silent_p.F2580F|COL6A3_uc010znj.1_Silent_p.F2179F|COL6A3_uc002vwj.2_Silent_p.F167F	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2786	VWFA 12.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCTCACTGGCGAAGGTGTATA	0.547													A	238249201	A	A	238249201	2	1	7	1	0	0	0	0	0	0	0	1	3701	1049	37	2		2	COL6A3	2	238249201	Silent	SNP	G	TCGA-02-2485-01A-01D-1494-08	11802222	238249201	4950172	10	435											
CNTN4	152330	broad.mit.edu	37	chr3	3076350	3076350	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagaggctgtgacaatagaCgaaatcacagataccactgc	9	11	1	4			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr3:3076350C>T	uc003bpc.2	+	16	2039	c.1818C>T	c.(1816-1818)GAC>GAT	p.D606D	CNTN4_uc003bpb.1_Silent_p.D277D|CNTN4_uc003bpd.1_Silent_p.D606D|CNTN4_uc003bpe.2_Silent_p.D278D|CNTN4_uc003bpf.2_Silent_p.D277D	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	606	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TGACAATAGACGAAATCACAG	0.537													T	3076350	T	T	3076350	2	4	7	1	0	0	0	0	0	0	0	1	3643	535	19	1		1	CNTN4	3	3076350	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08		3076350	194946080	11	436											
COLQ	8292	broad.mit.edu	37	chr3	15512054	15512054	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatccttacctgcttgcctcGttttcctggtcttcctgtgg	9	13	1	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr3:15512054G>A	uc003bzx.2	-	11	832	c.706C>T	c.(706-708)CGA>TGA	p.R236*	COLQ_uc003bzv.2_Nonsense_Mutation_p.R226*|COLQ_uc003bzz.2_Nonsense_Mutation_p.R227*|COLQ_uc010heo.2_Nonsense_Mutation_p.R202*|COLQ_uc003cac.1_RNA|COLQ_uc003cae.1_Nonsense_Mutation_p.R95*|COLQ_uc003cad.1_RNA	NM_005677	NP_005668	Q9Y215	COLQ_HUMAN	acetylcholinesterase collagen-like tail subunit	236	Heparan sulfate proteoglycan binding (Potential).|Collagen-like 1.				acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft					0						TGCTTGCCTCGTTTTCCTGGT	0.552													A	15512054	A	A	15512054	4	1	7	1	0	0	0	0	0	1	0	0	3713	1153	40	1	689	1	COLQ	3	15512054	Nonsense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	12435704	15512054	182510376	12	437											
ROBO1	6091	broad.mit.edu	37	chr3	79639041	79639042	+	Frame_Shift_Del	DEL	AG	-	-													agtgatatcatgaccaaaaaAggaacatgtttccatttcat							TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr3:79639041_79639042delAG	uc003dqe.2	-	2	228_229	c.20_21delCT	c.(19-21)CCTfs	p.P7fs		NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	7					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TGACCAAAAAAGGAACATGTTT	0.381													-	79639042	-	-	79639041	7	5	7	1	0	1	0	1	0	0	0	0	13513	59	3	0	5126	0	ROBO1	3	79639041	Frame_Shift_Del	DEL	AG	TCGA-02-2485-01A-01D-1494-08	64126987	79639041	118383389	13	438											
PIK3CA	5290	broad.mit.edu	37	chr3	178916921	178916921	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accctttttaaaagtaattgAaccagtaggcaaccgtgaag	8	8	0	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr3:178916921A>G	uc003fjk.2	+	2	465	c.308A>G	c.(307-309)GAA>GGA	p.E103G		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	103	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AAAGTAATTGAACCAGTAGGC	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			G	178916921	G	G	178916921	3	3	7	1	0	0	0	0	1	0	0	0	11913	246	9	4	310	4	PIK3CA	3	178916921	Missense_Mutation	SNP	A	TCGA-02-2485-01A-01D-1494-08	99277880	178916921	19105509	14	439											
HELT	391723	broad.mit.edu	37	chr4	185940979	185940979	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cactgcactccgctgattttCcccggggaagggaaaaaggt	12	11	0	1	rs147187823	byFrequency	TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr4:185940979C>T	uc011ckq.1	+	3	466	c.466C>T	c.(466-468)CCC>TCC	p.P156S	HELT_uc011cko.1_Missense_Mutation_p.P71S|HELT_uc003ixa.3_Missense_Mutation_p.P71S|HELT_uc011ckp.1_Missense_Mutation_p.P15S	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	156							DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		CGCTGATTTTCCCCGGGGAAG	0.632													T	185940979	T	T	185940979	3	4	7	1	0	0	0	0	1	0	0	0	7048	855	30	3	476	3	HELT	4	185940979	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08		185940979	5213297	15	440											
SLCO6A1	133482	broad.mit.edu	37	chr5	101735262	101735262	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtaatatatacataccgcGtcatggccaagacgattggt	10	8	1	1	rs139495343	by1000genomes	TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr5:101735262G>A	uc003knn.2	-	10	1983	c.1811C>T	c.(1810-1812)ACG>ATG	p.T604M	SLCO6A1_uc003kno.2_Missense_Mutation_p.T351M|SLCO6A1_uc003knp.2_Missense_Mutation_p.T604M|SLCO6A1_uc003knq.2_Missense_Mutation_p.T542M	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	604	Helical; Name=10; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TACATACCGCGTCATGGCCAA	0.284													A	101735262	A	A	101735262	3	1	7	1	0	0	0	0	1	0	0	0	14732	1145	40	1	364	1	SLCO6A1	5	101735262	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08		101735262	79179998	16	441											
REEP2	51308	broad.mit.edu	37	chr5	137781275	137781275	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaaacccatcaaaaaagcGcccaaagctgaggtgagggc	11	12	1	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr5:137781275G>A	uc003lcz.2	+	7	800	c.678G>A	c.(676-678)GCG>GCA	p.A226A	REEP2_uc003lda.2_Silent_p.A228A|REEP2_uc011cyt.1_Silent_p.A187A	NM_016606	NP_057690	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	226						integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			TCAAAAAAGCGCCCAAAGCTG	0.592													A	137781275	A	A	137781275	2	1	7	1	0	0	0	0	0	0	0	1	13205	1074	38	1		1	REEP2	5	137781275	Silent	SNP	G	TCGA-02-2485-01A-01D-1494-08	36046013	137781275	43133985	17	442											
PCDHA12	56137	broad.mit.edu	37	chr5	140257259	140257259	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgtgagccggtgcgcgccGggcaagcccacgctggtgtg	17	14	0	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr5:140257259G>A	uc003lic.2	+	1	2329	c.2202G>A	c.(2200-2202)CCG>CCA	p.P734P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.P734P	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	734	5 X 4 AA repeats of P-X-X-P.|Cytoplasmic (Potential).|PXXP 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCGCGCCGGGCAAGCCCA	0.682													A	140257259	A	A	140257259	2	1	7	1	0	0	0	0	0	0	0	1	11522	1103	39	2		2	PCDHA12	5	140257259	Silent	SNP	G	TCGA-02-2485-01A-01D-1494-08	2475984	140257259	40658001	18	443											
MAML1	9794	broad.mit.edu	37	chr5	179192466	179192466	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tctgggagttgccatctcttCcaatggactgcctccagcct	9	14	2	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr5:179192466C>A	uc003mkm.2	+	2	718	c.455C>A	c.(454-456)TCC>TAC	p.S152Y	MAML1_uc003mkn.1_Missense_Mutation_p.S152Y	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	152					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCATCTCTTCCAATGGACTG	0.602													A	179192466	A	A	179192466	3	1	7	1	0	0	0	0	1	0	0	0	9205	855	30	5	461	5	MAML1	5	179192466	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	38935207	179192466	1722794	19	444											
DSP	1832	broad.mit.edu	37	chr6	7583891	7583891	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagcccagattgcttcaggGggtgtagtagaccctgtgaa	14	8	1	3			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr6:7583891G>A	uc003mxp.1	+	24	6675	c.6396G>A	c.(6394-6396)GGG>GGA	p.G2132G	DSP_uc003mxq.1_Silent_p.G1533G	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2132	Plectin 4.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TTGCTTCAGGGGGTGTAGTAG	0.473													A	7583891	A	A	7583891	2	1	7	1	0	0	0	0	0	0	0	1	4781	1219	43	3		3	DSP	6	7583891	Silent	SNP	G	TCGA-02-2485-01A-01D-1494-08		7583891	163531176	20	445											
JARID2	3720	broad.mit.edu	37	chr6	15520428	15520428	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagcgacagtggacgtgccCccctcccgtctgtcagcctc	11	17	2	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr6:15520428C>T	uc003nbj.2	+	18	3931	c.3687C>T	c.(3685-3687)CCC>CCT	p.P1229P	JARID2_uc011div.1_Silent_p.P1057P	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	1229					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				TGGACGTGCCCCCCTCCCGTC	0.373													T	15520428	T	T	15520428	2	4	7	1	0	0	0	0	0	0	0	1	7945	610	22	3		3	JARID2	6	15520428	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08	7936537	15520428	155594639	21	446											
HIST1H2BF	8343	broad.mit.edu	37	chr6	26199947	26199947	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaggtccaccccgacaccgGcatctcatccaaggccatgg	10	17	1	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr6:26199947G>A	uc003ngx.2	+	1	161	c.161G>A	c.(160-162)GGC>GAC	p.G54D	HIST1H3D_uc003ngv.2_5'Flank|HIST1H2AD_uc003ngw.2_5'Flank	NM_003522	NP_003513	P62807	H2B1C_HUMAN	histone cluster 1, H2bf	54					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0		all_hematologic(11;0.196)				CCCGACACCGGCATCTCATCC	0.567													A	26199947	A	A	26199947	3	1	7	1	0	0	0	0	1	0	0	0	7145	1203	42	3	163	3	HIST1H2BF	6	26199947	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	10679519	26199947	144915120	22	447											
LGSN	51557	broad.mit.edu	37	chr6	64004847	64004847	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggacatatccgtttctcccActtcagttgaacaaacatat	5	11	2	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr6:64004847A>C	uc003peh.2	-	2	168	c.134T>G	c.(133-135)GTG>GGG	p.V45G	LGSN_uc003pei.2_Missense_Mutation_p.V45G|LGSN_uc003pej.1_Missense_Mutation_p.V45G	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	45					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	CGTTTCTCCCACTTCAGTTGA	0.393													C	64004847	C	C	64004847	3	2	7	1	0	0	0	0	1	0	0	0	8759	159	6	5	1407	5	LGSN	6	64004847	Missense_Mutation	SNP	A	TCGA-02-2485-01A-01D-1494-08	37804900	64004847	107110220	23	448											
HECA	51696	broad.mit.edu	37	chr6	139487771	139487771	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaaagaagaagtctggctccGagaagaacacagggaggcct	13	8	1	4			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr6:139487771G>A	uc003qin.2	+	2	907	c.622G>A	c.(622-624)GAG>AAG	p.E208K		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	208					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		GTCTGGCTCCGAGAAGAACAC	0.592													A	139487771	A	A	139487771	3	1	7	1	0	0	0	0	1	0	0	0	7038	1059	37	2	628	2	HECA	6	139487771	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	75482924	139487771	31627296	24	449											
NOD1	10392	broad.mit.edu	37	chr7	30492358	30492358	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagaagaatttgacccctgcGtctagccggcccgtggccca	11	14	1	3	rs150842987		TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr7:30492358G>A	uc003tav.2	-	6	1198	c.675C>T	c.(673-675)GAC>GAT	p.D225D	NOD1_uc010kvs.2_Intron	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	225	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						TGACCCCTGCGTCTAGCCGGC	0.577													A	30492358	A	A	30492358	2	1	7	1	0	0	0	0	0	0	0	1	10516	1136	40	1		1	NOD1	7	30492358	Silent	SNP	G	TCGA-02-2485-01A-01D-1494-08		30492358	128646305	25	450											
VPS41	27072	broad.mit.edu	37	chr7	38835094	38835094	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agtcccccagccaataatcaGtgtcacattgtccttccagc	6	15	2	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr7:38835094G>C	uc003tgy.2	-	9	714	c.688C>G	c.(688-690)CTG>GTG	p.L230V	VPS41_uc003tgz.2_Missense_Mutation_p.L205V|VPS41_uc010kxn.2_Intron	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	230					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						CCAATAATCAGTGTCACATTG	0.468													C	38835094	C	C	38835094	3	2	7	1	0	0	0	0	1	0	0	0	17207	1020	36	5	1960	5	VPS41	7	38835094	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	8342736	38835094	120303569	26	451											
POM121L12	285877	broad.mit.edu	37	chr7	53103860	53103860	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccccgcaggccgccccgccGcccaggagctcctggacccc	12	23	0	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr7:53103860G>A	uc003tpz.2	+	1	512	c.496G>A	c.(496-498)GCC>ACC	p.A166T		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	166											0						ccgccccgccgcccAGGAGCT	0.587													A	53103860	A	A	53103860	3	1	7	1	0	0	0	0	1	0	0	0	12241	1087	38	1	498	1	POM121L12	7	53103860	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	14268766	53103860	106034803	27	452											
POM121L12	285877	broad.mit.edu	37	chr7	53104151	53104151	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtccagcccgccccatccGccatctgggacttctgggag	12	16	2	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr7:53104151G>A	uc003tpz.2	+	1	803	c.787G>A	c.(787-789)GCC>ACC	p.A263T		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	263											0						CGCCCCATCCGCCATCTGGGA	0.662													A	53104151	A	A	53104151	3	1	7	1	0	0	0	0	1	0	0	0	12241	1087	38	1	789	1	POM121L12	7	53104151	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	291	53104151	106034512	28	453											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr7:55221822C>A	uc003tqk.2	+	7	1112	c.866C>A	c.(865-867)GCC>GAC	p.A289D	EGFR_uc003tqh.2_Missense_Mutation_p.A289D|EGFR_uc003tqi.2_Missense_Mutation_p.A289D|EGFR_uc003tqj.2_Missense_Mutation_p.A289D|EGFR_uc010kzg.1_Missense_Mutation_p.A244D|EGFR_uc011kco.1_Missense_Mutation_p.A236D|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55221822	A	A	55221822	3	1	7	1	0	0	0	0	1	0	0	0	4967	739	26	5	892	5	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	2117671	55221822	103916841	29	454											
LRWD1	222229	broad.mit.edu	37	chr7	102106371	102106371	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaccacctggagacgctgcCggacaacctgggcctgtccc	11	17	0	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr7:102106371C>T	uc003uzn.2	+	2	326	c.188C>T	c.(187-189)CCG>CTG	p.P63L	ALKBH4_uc003uzl.2_5'Flank|ALKBH4_uc003uzm.2_5'Flank|LRWD1_uc003uzo.2_5'UTR	NM_152892	NP_690852	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain	63	LRR 2.				chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			skin(1)	1						GAGACGCTGCCGGACAACCTG	0.622													T	102106371	T	T	102106371	3	4	7	1	0	0	0	0	1	0	0	0	9047	652	23	2	194	2	LRWD1	7	102106371	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	46884549	102106371	57032292	30	455											
CHRM2	1129	broad.mit.edu	37	chr7	136700738	136700738	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctaagcagcctgcaaaaaagAagcctcctccttcccgggaa	8	14	0	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr7:136700738A>G	uc003vtf.1	+	4	1749	c.1126A>G	c.(1126-1128)AAG>GAG	p.K376E	CHRM2_uc003vtg.1_Missense_Mutation_p.K376E|CHRM2_uc003vtj.1_Missense_Mutation_p.K376E|CHRM2_uc003vtk.1_Missense_Mutation_p.K376E|CHRM2_uc003vtl.1_Missense_Mutation_p.K376E|CHRM2_uc003vtm.1_Missense_Mutation_p.K376E|CHRM2_uc003vti.1_Missense_Mutation_p.K376E|CHRM2_uc003vto.1_Missense_Mutation_p.K376E|CHRM2_uc003vtn.1_Missense_Mutation_p.K376E|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	376	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	TGCAAAAAAGAAGCCTCCTCC	0.478													G	136700738	G	G	136700738	3	3	7	1	0	0	0	0	1	0	0	0	3377	247	9	4	1128	4	CHRM2	7	136700738	Missense_Mutation	SNP	A	TCGA-02-2485-01A-01D-1494-08	34594367	136700738	22437925	31	456											
RP1	6101	broad.mit.edu	37	chr8	55541829	55541829	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taatttggccccaggcccaaCgatggatgaactctcctctt	8	13	2	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr8:55541829C>T	uc003xsd.1	+	4	5535	c.5387C>T	c.(5386-5388)ACG>ATG	p.T1796M	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1796					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.T1796T(1)		skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCAGGCCCAACGATGGATGAA	0.448													T	55541829	T	T	55541829	3	4	7	1	0	0	0	0	1	0	0	0	13532	536	19	1	5397	1	RP1	8	55541829	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08		55541829	90822193	32	457											
DOCK8	81704	broad.mit.edu	37	chr9	286571	286571	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcggggacttcactgatgaCgacttggacgtggtgttcac	13	10	2	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr9:286571C>T	uc003zgf.2	+	3	379	c.267C>T	c.(265-267)GAC>GAT	p.D89D	DOCK8_uc011lls.1_Silent_p.D89D|DOCK8_uc010mgu.2_Translation_Start_Site|DOCK8_uc010mgv.2_Silent_p.D21D|DOCK8_uc010mgt.2_Silent_p.D21D|DOCK8_uc003zgg.2_Silent_p.D21D|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	89					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TCACTGATGACGACTTGGACG	0.507													T	286571	T	T	286571	2	4	7	1	0	0	0	0	0	0	0	1	4693	535	19	1		1	DOCK8	9	286571	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08		286571	140926860	33	458											
TMEM215	401498	broad.mit.edu	37	chr9	32784414	32784414	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacgagctgctgtgggtccGcaaattgccctgcttccgga	13	12	0	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr9:32784414G>A	uc003zri.3	+	2	598	c.233G>A	c.(232-234)CGC>CAC	p.R78H		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	78						integral to membrane					0						CTGTGGGTCCGCAAATTGCCC	0.597													A	32784414	A	A	32784414	3	1	7	1	0	0	0	0	1	0	0	0	16135	1087	38	1	235	1	TMEM215	9	32784414	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	32497843	32784414	108429017	34	459											
TDRD7	23424	broad.mit.edu	37	chr9	100227272	100227272	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccgaggaggacgcctggttaCgggcacaggtcatctcaaca	13	12	2	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr9:100227272C>A	uc004axj.2	+	8	1816	c.1591C>A	c.(1591-1593)CGG>AGG	p.R531R	TDRD7_uc011lux.1_Silent_p.R457R	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	531	Tudor 1.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				CGCCTGGTTACGGGCACAGGT	0.423													A	100227272	A	A	100227272	2	1	7	1	0	0	0	0	0	0	0	1	15732	527	19	5		5	TDRD7	9	100227272	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08	67442858	100227272	40986159	35	460											
TGFBR1	7046	broad.mit.edu	37	chr9	101900167	101900167	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cattgcttgttcagagaacaAttgcgagaactattgtgtta	9	6	1	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr9:101900167A>G	uc004azc.2	+	4	677	c.601A>G	c.(601-603)ATT>GTT	p.I201V	TGFBR1_uc004azd.2_Missense_Mutation_p.I124V|TGFBR1_uc011lvc.1_Missense_Mutation_p.I132V	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	201	Cytoplasmic (Potential).|GS.				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				TCAGAGAACAATTGCGAGAAC	0.358													G	101900167	G	G	101900167	3	3	7	1	0	0	0	0	1	0	0	0	15818	101	4	4	615	4	TGFBR1	9	101900167	Missense_Mutation	SNP	A	TCGA-02-2485-01A-01D-1494-08	1672895	101900167	39313264	36	461											
NRP1	8829	broad.mit.edu	37	chr10	33545336	33545336	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaaaccatggagagaatgCccgatgaggatcggattcga	12	7	0	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr10:33545336C>T	uc001iwx.3	-	5	1245	c.722G>A	c.(721-723)GGC>GAC	p.G241D	NRP1_uc001iwv.3_Missense_Mutation_p.G241D|NRP1_uc009xlz.2_Missense_Mutation_p.G241D|NRP1_uc001iww.3_Missense_Mutation_p.G60D|NRP1_uc001iwy.3_Missense_Mutation_p.G241D|NRP1_uc001iwz.2_Missense_Mutation_p.G241D|NRP1_uc001ixa.2_Missense_Mutation_p.G241D|NRP1_uc001ixb.1_Missense_Mutation_p.G241D|NRP1_uc001ixc.1_Missense_Mutation_p.G241D	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	241	Extracellular (Potential).|CUB 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	GGAGAGAATGCCCGATGAGGA	0.483													T	33545336	T	T	33545336	3	4	7	1	0	0	0	0	1	0	0	0	10660	739	26	3	2112	3	NRP1	10	33545336	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08		33545336	101989411	37	462											
BMS1	9790	broad.mit.edu	37	chr10	43312886	43312888	+	In_Frame_Del	DEL	GAA	-	-													tgtttgatgcagaatatgatGaaggagaaagcacatatttt							TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr10:43312886_43312888delGAA	uc001jaj.2	+	15	2882_2884	c.2524_2526delGAA	c.(2524-2526)GAAdel	p.E842del		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	842					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						AGAATATGATGAAGGAGAAAGCA	0.384													-	43312888	-	-	43312886	7	5	7	1	0	1	0	1	0	0	0	0	1472	1291	45	0	2578	0	BMS1	10	43312886	In_Frame_Del	DEL	GAA	TCGA-02-2485-01A-01D-1494-08	9767550	43312886	92221861	38	463											
CYP2C8	1558	broad.mit.edu	37	chr10	96827051	96827051	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttccccatcccaaaattcCgcaaggttgtgagggagaaa	9	11	1	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr10:96827051C>T	uc001kkb.2	-	3	490	c.395G>A	c.(394-396)CGG>CAG	p.R132Q	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.R62Q|CYP2C8_uc010qob.1_Missense_Mutation_p.R46Q|CYP2C8_uc010qoc.1_Missense_Mutation_p.R30Q|CYP2C8_uc010qod.1_Missense_Mutation_p.R46Q	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	132					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	CCCAAAATTCCGCAAGGTTGT	0.483													T	96827051	T	T	96827051	3	4	7	1	0	0	0	0	1	0	0	0	4167	652	23	2	1105	2	CYP2C8	10	96827051	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	53514165	96827051	38707696	39	464											
NEURL	9148	broad.mit.edu	37	chr10	105331407	105331407	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgggccaaggcgctgcctgaGgagtttgccaatgagggcaa	16	9	0	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr10:105331407G>T	uc001kxh.2	+	3	887	c.477G>T	c.(475-477)GAG>GAT	p.E159D		NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	159	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		CGCTGCCTGAGGAGTTTGCCA	0.612													T	105331407	T	T	105331407	3	4	7	1	0	0	0	0	1	0	0	0	10345	991	35	5	487	5	NEURL	10	105331407	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	8504356	105331407	30203340	40	465											
MUC2	4583	broad.mit.edu	37	chr11	1080301	1080301	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaccgtatatgacgacatcGgggacagtggctgcgttcct	13	11	0	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr11:1080301G>A	uc001lsx.1	+	8	1048	c.1021G>A	c.(1021-1023)GGG>AGG	p.G341R		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	341	TIL.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TGACGACATCGGGGACAGTGG	0.642													A	1080301	A	A	1080301	3	1	7	1	0	0	0	0	1	0	0	0	9975	1116	39	2	1051	2	MUC2	11	1080301	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08		1080301	133926215	41	466											
OR5M11	219487	broad.mit.edu	37	chr11	56310330	56310330	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agatgcaaactctcctggacGttttcacactgtagcgcaga	9	11	2	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr11:56310330G>C	uc010rjl.1	-	1	404	c.404C>G	c.(403-405)ACG>AGG	p.T135R		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTCCTGGACGTTTTCACACT	0.498													C	56310330	C	C	56310330	3	2	7	1	0	0	0	0	1	0	0	0	11174	1145	40	5	516	5	OR5M11	11	56310330	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	55230029	56310330	78696186	42	467											
UVRAG	7405	broad.mit.edu	37	chr11	75590966	75590966	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttggaattatgccagaccGtcttgatacatctgtgtctt	8	8	3	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr11:75590966G>A	uc001oxc.2	+	4	555	c.314G>A	c.(313-315)CGT>CAT	p.R105H	UVRAG_uc010rrw.1_Missense_Mutation_p.R4H	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	105	C2.				DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						ATGCCAGACCGTCTTGATACA	0.423													A	75590966	A	A	75590966	3	1	7	1	0	0	0	0	1	0	0	0	17105	1145	40	1	328	1	UVRAG	11	75590966	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	19280636	75590966	59415550	43	468											
NOP2	4839	broad.mit.edu	37	chr12	6675301	6675301	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctcatcctcagagttggagTcagctccatagtcatctacc	7	14	5	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr12:6675301T>G	uc001qpk.1	-	4	484	c.440A>C	c.(439-441)GAC>GCC	p.D147A	NOP2_uc009zeq.1_5'Flank|NOP2_uc001qph.1_Missense_Mutation_p.D143A|NOP2_uc001qpi.1_Missense_Mutation_p.D143A|NOP2_uc001qpj.1_Intron|NOP2_uc001qpl.1_Missense_Mutation_p.D147A|NOP2_uc001qpm.1_Missense_Mutation_p.D147A			P46087	NOP2_HUMAN	Homo sapiens cDNA FLJ31646 fis, clone NT2RI2003921, highly similar to PROLIFERATING-CELL NUCLEOLAR ANTIGEN P120.	147					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						AGAGTTGGAGTCAGCTCCATA	0.488													G	6675301	G	G	6675301	3	3	7	1	0	0	0	0	1	0	0	0	10538	1667	58	5	2046	5	NOP2	12	6675301	Missense_Mutation	SNP	T	TCGA-02-2485-01A-01D-1494-08		6675301	127176594	44	469											
GEFT	115557	broad.mit.edu	37	chr12	58010639	58010640	+	Frame_Shift_Ins	INS	-	A	A													tccaaaaacccctccctgccINSaagccagacttgccaagctg							TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr12:58010639_58010640insA	uc001spb.2	+	15	2165_2166	c.1705_1706insA	c.(1705-1707)CAAfs	p.Q569fs	GEFT_uc009zpy.2_Frame_Shift_Ins_p.Q608fs|GEFT_uc001spa.2_Frame_Shift_Ins_p.Q463fs|uc001spc.2_Intron|GEFT_uc001spd.2_Frame_Shift_Ins_p.Q274fs	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	569					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					CCCTCCCTGCCAAGCCAGACTT	0.554													A	58010640	A	A	58010639	7	5	7	1	0	1	1	0	0	0	0	0	6328	595	21	0	1985	0	GEFT	12	58010639	Frame_Shift_Ins	INS	-	TCGA-02-2485-01A-01D-1494-08	51335338	58010639	75841256	45	470											
ATP8A2	51761	broad.mit.edu	37	chr13	26349058	26349058	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgggtgaccaagtgcatcttGtactgcttctataagaacgt	10	9	2	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr13:26349058G>T	uc001uqk.2	+	27	2782	c.2640G>T	c.(2638-2640)TTG>TTT	p.L880F	ATP8A2_uc010tdi.1_Missense_Mutation_p.L840F|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.L430F	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	840	Helical; (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGTGCATCTTGTACTGCTTCT	0.388													T	26349058	T	T	26349058	3	4	7	1	0	0	0	0	1	0	0	0	1193	1368	48	5	2746	5	ATP8A2	13	26349058	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08		26349058	88820820	46	471											
SIX4	51804	broad.mit.edu	37	chr14	61189964	61189964	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcggaggggttcctgtcgcGctgccggcggttcttgaacc	15	13	1	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr14:61189964G>A	uc001xfc.2	-	1	829	c.829C>T	c.(829-831)CGC>TGC	p.R277C	SIX4_uc010app.1_Missense_Mutation_p.R269C	NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	277	Homeobox.					nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		TTCCTGTCGCGCTGCCGGCGG	0.502													A	61189964	A	A	61189964	3	1	7	1	0	0	0	0	1	0	0	0	14349	1087	38	1	1528	1	SIX4	14	61189964	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08		61189964	46159576	47	472											
ACOT1	641371	broad.mit.edu	37	chr14	74008216	74008216	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaacctgggccctttcctggCattgtggacatgttcggaac	12	11	0	0	rs142030871	by1000genomes	TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr14:74008216C>G	uc001xol.1	+	2	675	c.477C>G	c.(475-477)GGC>GGG	p.G159G	HEATR4_uc010tua.1_Intron|ACOT1_uc010tuc.1_Silent_p.G159G	NM_001037161	NP_001032238	Q86TX2	ACOT1_HUMAN	acyl-CoA thioesterase 1	159					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	cytosol	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(108;1.37e-45)|BRCA - Breast invasive adenocarcinoma(234;0.0033)		CCTTTCCTGGCATTGTGGACA	0.363													G	74008216	G	G	74008216	2	3	7	1	0	0	0	0	0	0	0	1	148	697	25	5		5	ACOT1	14	74008216	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08	12818252	74008216	33341324	48	473											
AGBL1	123624	broad.mit.edu	37	chr15	86838560	86838560	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagatgttctctgccagacGctgggagggaatccgtgtcc	13	11	1	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr15:86838560G>A	uc002blz.1	+	16	2237	c.2157G>A	c.(2155-2157)ACG>ACA	p.T719T	AGBL1_uc002bma.1_Silent_p.T450T|AGBL1_uc002bmb.1_Silent_p.T413T	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	719					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TCTGCCAGACGCTGGGAGGGA	0.507													A	86838560	A	A	86838560	2	1	7	1	0	0	0	0	0	0	0	1	375	1074	38	1		1	AGBL1	15	86838560	Silent	SNP	G	TCGA-02-2485-01A-01D-1494-08		86838560	15692832	49	474											
ACSM2B	348158	broad.mit.edu	37	chr16	20548636	20548636	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgtctcgaagtttggttcGttgaattttccctgtgacag	10	8	1	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr16:20548636G>A	uc002dhj.3	-	15	1888	c.1678C>T	c.(1678-1680)CGA>TGA	p.R560*	ACSM2B_uc002dhk.3_Nonsense_Mutation_p.R560*	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	560					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						AGTTTGGTTCGTTGAATTTTC	0.473													A	20548636	A	A	20548636	4	1	7	1	0	0	0	0	0	1	0	0	184	1153	40	1	59	1	ACSM2B	16	20548636	Nonsense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08		20548636	69806117	50	475											
CACNG3	10368	broad.mit.edu	37	chr16	24366257	24366257	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccaccgcagcagacacaaCgtcattctcagcgcgggcat	9	15	2	1	rs147734423		TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr16:24366257C>T	uc002dmf.2	+	3	1599	c.399C>T	c.(397-399)AAC>AAT	p.N133N		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	133					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		GCAGACACAACGTCATTCTCA	0.587													T	24366257	T	T	24366257	2	4	7	1	0	0	0	0	0	0	0	1	2558	535	19	1		1	CACNG3	16	24366257	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08	3817621	24366257	65988496	51	476											
ITGAM	3684	broad.mit.edu	37	chr16	31286996	31286996	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agaccattcagaaccagcttCgggagaagatctttgcgatc	10	10	2	4			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr16:31286996C>T	uc002ebq.2	+	9	1083	c.985C>T	c.(985-987)CGG>TGG	p.R329W	ITGAM_uc002ebr.2_Missense_Mutation_p.R329W|ITGAM_uc010cam.1_5'UTR	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	329	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GAACCAGCTTCGGGAGAAGAT	0.542													T	31286996	T	T	31286996	3	4	7	1	0	0	0	0	1	0	0	0	7887	875	31	2	1019	2	ITGAM	16	31286996	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	6920739	31286996	59067757	52	477											
HYDIN	54768	broad.mit.edu	37	chr16	71004595	71004595	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggctctagaccttgcccaCgtgccaggagggtaagcttt	13	11	1	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr16:71004595C>T	uc002ezr.2	-	36	5572	c.5444G>A	c.(5443-5445)CGT>CAT	p.R1815H		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1816										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ACCTTGCCCACGTGCCAGGAG	0.507													T	71004595	T	T	71004595	3	4	7	1	0	0	0	0	1	0	0	0	7467	536	19	1	10122	1	HYDIN	16	71004595	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	39717599	71004595	19350158	53	478											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577538	T	T	7577538	3	4	7	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08		7577538	73617672	54	479											
TP53	7157	broad.mit.edu	37	chr17	7578550	7578550	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	acatcttgttgagggcagggGagtactgtaggaagaggaag	17	4	1	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr17:7578550G>T	uc002gim.2	-	5	574	c.380C>A	c.(379-381)TCC>TAC	p.S127Y	TP53_uc002gig.1_Missense_Mutation_p.S127Y|TP53_uc002gih.2_Missense_Mutation_p.S127Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.S127Y|TP53_uc010cni.1_Missense_Mutation_p.S127Y|TP53_uc002gij.2_Missense_Mutation_p.S127Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.S34Y|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.S88Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	127	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> C (in a sporadic cancer; somatic mutation).|S -> F (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S127F(18)|p.S127Y(8)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.Y126_N131delYSPALN(3)|p.S127P(3)|p.S127T(2)|p.P128fs*42(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.P128fs*18(1)|p.Y126fs*11(1)|p.S127S(1)|p.S127C(1)|p.S127_Q136del10(1)|p.P13fs*18(1)|p.?(1)|p.S127fs*43(1)|p.S127fs*42(1)|p.Y126fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGGCAGGGGAGTACTGTAG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578550	T	T	7578550	3	4	7	1	0	0	0	0	1	0	0	0	16378	1174	41	5	918	5	TP53	17	7578550	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	1012	7578550	73616660	55	480											
WNT3	7473	broad.mit.edu	37	chr17	44851175	44851175	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggcatgatctcgatgtaatTgcggcagaagcgcagttgct	14	8	1	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr17:44851175T>C	uc002ikv.2	-	2	300	c.181A>G	c.(181-183)AAT>GAT	p.N61D		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	61					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			TCGATGTAATTGCGGCAGAAG	0.657													C	44851175	C	C	44851175	3	2	7	1	0	0	0	0	1	0	0	0	17385	1812	63	4	898	4	WNT3	17	44851175	Missense_Mutation	SNP	T	TCGA-02-2485-01A-01D-1494-08	37272625	44851175	36344035	56	481											
C17orf47	284083	broad.mit.edu	37	chr17	56621053	56621053	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	atttgtgattgtaagttattCttctggtcttgaaaactcaa	7	5	4	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr17:56621053C>A	uc002iwq.1	-	1	631	c.495G>T	c.(493-495)AAG>AAT	p.K165N	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	165										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTAAGTTATTCTTCTGGTCTT	0.478													A	56621053	A	A	56621053	3	1	7	1	0	0	0	0	1	0	0	0	1858	912	32	5	1225	5	C17orf47	17	56621053	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	11769878	56621053	24574157	57	482											
CD300A	11314	broad.mit.edu	37	chr17	72469900	72469900	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacctcagcttcacagtgaCcctggagaatctcacagagg	9	12	3	3			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr17:72469900C>T	uc002jkv.2	+	2	587	c.266C>T	c.(265-267)ACC>ATC	p.T89I	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	89	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						TTCACAGTGACCCTGGAGAAT	0.537													T	72469900	T	T	72469900	3	4	7	1	0	0	0	0	1	0	0	0	2996	507	18	3	272	3	CD300A	17	72469900	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	15848847	72469900	8725310	58	483											
THEG	51298	broad.mit.edu	37	chr19	375850	375850	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgttcggggtctgtgacccGccggctctcgtacacagagc	14	14	2	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:375850G>A	uc002lol.2	-	1	160	c.121C>T	c.(121-123)CGG>TGG	p.R41W	THEG_uc002lom.2_Missense_Mutation_p.R41W	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	41					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGTGACCCGCCGGCTCTCG	0.672													A	375850	A	A	375850	3	1	7	1	0	0	0	0	1	0	0	0	15854	1086	38	1	1050	1	THEG	19	375850	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08		375850	58753133	59	484											
EEF2	1938	broad.mit.edu	37	chr19	3980665	3980665	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggttggcaccattttggaaAtatacatcataagagggcct	10	7	1	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:3980665A>C	uc002lze.2	-	9	1276	c.1193T>G	c.(1192-1194)ATT>AGT	p.I398S		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	398						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		CATTTTGGAAATATACATCAT	0.527													C	3980665	C	C	3980665	3	2	7	1	0	0	0	0	1	0	0	0	4929	101	4	5	1411	5	EEF2	19	3980665	Missense_Mutation	SNP	A	TCGA-02-2485-01A-01D-1494-08	3604815	3980665	55148318	60	485											
MUC16	94025	broad.mit.edu	37	chr19	9046871	9046871	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggaattgtcccagaaaccGttgtgctggtttctgcagga	13	8	1	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:9046871G>A	uc002mkp.2	-	5	34964	c.34760C>T	c.(34759-34761)ACG>ATG	p.T11587M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11589	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCCAGAAACCGTTGTGCTGGT	0.522													A	9046871	A	A	9046871	3	1	7	1	0	0	0	0	1	0	0	0	9973	1145	40	1	9083	1	MUC16	19	9046871	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	5066206	9046871	50082112	61	486											
OR7E24	26648	broad.mit.edu	37	chr19	9361873	9361873	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcgctgggctgttcctgtccAtgtacctggtcacggtgctg	13	12	1	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:9361873A>G	uc002mlb.1	+	1	154	c.154A>G	c.(154-156)ATG>GTG	p.M52V		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	52	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTTCCTGTCCATGTACCTGGT	0.577													G	9361873	G	G	9361873	3	3	7	1	0	0	0	0	1	0	0	0	11221	217	8	4	156	4	OR7E24	19	9361873	Missense_Mutation	SNP	A	TCGA-02-2485-01A-01D-1494-08	315002	9361873	49767110	62	487											
ATP13A1	57130	broad.mit.edu	37	chr19	19756294	19756294	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggacgcggtcggccaggagCgccaggcagaagtccaggag	18	11	0	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:19756294C>T	uc002nnh.3	-	26	3580	c.3552G>A	c.(3550-3552)GCG>GCA	p.A1184A	GMIP_uc002nnd.2_5'Flank|GMIP_uc010xrb.1_5'Flank|GMIP_uc010xrc.1_5'Flank|ATP13A1_uc002nne.2_Silent_p.A324A|ATP13A1_uc002nnf.3_Silent_p.A552A|ATP13A1_uc002nng.2_Silent_p.A1066A	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	ATPase type 13A1	1184	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(3)|large_intestine(2)|central_nervous_system(1)	6						CGGCCAGGAGCGCCAGGCAGA	0.647													T	19756294	T	T	19756294	2	4	7	1	0	0	0	0	0	0	0	1	1123	755	27	1		1	ATP13A1	19	19756294	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08	10394421	19756294	39372689	63	488											
ZNF681	148213	broad.mit.edu	37	chr19	23927494	23927494	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgattaaaggctttgtcacaTtcttcacgtttgtagggatt	9	6	3	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:23927494T>C	uc002nrk.3	-	4	1000	c.858A>G	c.(856-858)GAA>GAG	p.E286E	ZNF681_uc002nrl.3_Silent_p.E217E|ZNF681_uc002nrj.3_Silent_p.E217E	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	286	C2H2-type 5; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CTTTGTCACATTCTTCACGTT	0.363													C	23927494	C	C	23927494	2	2	7	1	0	0	0	0	0	0	0	1	18085	1490	52	4		4	ZNF681	19	23927494	Silent	SNP	T	TCGA-02-2485-01A-01D-1494-08	4171200	23927494	35201489	64	489											
ZNF571	51276	broad.mit.edu	37	chr19	38056190	38056193	+	Frame_Shift_Del	DEL	GTAA	-	-													cctgaatgaactctcaggtgGtaagtaagttgtgagccacg							TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:38056190_38056193delGTAA	uc002ogt.2	-	4	1238_1241	c.1137_1140delTTAC	c.(1135-1140)ACTTACfs	p.T379fs	uc002ogm.2_Intron|uc002ogn.2_Intron|ZNF540_uc002ogo.2_Intron|ZNF540_uc002ogp.2_Intron|ZNF540_uc002ogq.2_Intron|ZNF571_uc002ogr.1_Intron|uc002ogs.1_5'Flank|ZNF571_uc010efp.2_Frame_Shift_Del_p.T379fs	NM_016536	NP_057620	Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	379_380	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTCTCAGGTGGTAAGTAAGTTGTG	0.377													-	38056193	-	-	38056190	7	5	7	1	0	1	0	1	0	0	0	0	18000	1256	44	0	693	0	ZNF571	19	38056190	Frame_Shift_Del	DEL	GTAA	TCGA-02-2485-01A-01D-1494-08	14128696	38056190	21072793	65	490											
EXOSC5	56915	broad.mit.edu	37	chr19	41903139	41903139	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagcaggttctgttcgcagGcaaagtgccggaggctgcag	15	10	1	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:41903139G>A	uc002oqo.2	-	1	118	c.95C>T	c.(94-96)GCC>GTC	p.A32V	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Intron|BCKDHA_uc002oqp.1_5'Flank|BCKDHA_uc002oqq.2_5'Flank|BCKDHA_uc002oqr.2_5'Flank|BCKDHA_uc010xvz.1_5'Flank	NM_020158	NP_064543	Q9NQT4	EXOS5_HUMAN	exosome component Rrp46	32					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding				0						CTGTTCGCAGGCAAAGTGCCG	0.582													A	41903139	A	A	41903139	3	1	7	1	0	0	0	0	1	0	0	0	5318	1203	42	3	636	3	EXOSC5	19	41903139	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	3846949	41903139	17225844	66	491											
IRGC	56269	broad.mit.edu	37	chr19	44222975	44222975	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggcgcggctctcacgggcGtcatggagaccacgatgcaa	14	13	2	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:44222975G>A	uc002oxh.2	+	2	412	c.265G>A	c.(265-267)GTC>ATC	p.V89I		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	89	GTP.					membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				TCTCACGGGCGTCATGGAGAC	0.701													A	44222975	A	A	44222975	3	1	7	1	0	0	0	0	1	0	0	0	7838	1145	40	1	267	1	IRGC	19	44222975	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	2319836	44222975	14906008	67	492											
EXOC3L2	90332	broad.mit.edu	37	chr19	45728158	45728158	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccccacccgggccaggcGctcggccagagctctgtggg	17	16	1	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:45728158G>A	uc002pay.1	-	6	459	c.418C>T	c.(418-420)CGC>TGC	p.R140C		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	140										ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		CGGGCCAGGCGCTCGGCCAGA	0.637													A	45728158	A	A	45728158	3	1	7	1	0	0	0	0	1	0	0	0	5305	1087	38	1	831	1	EXOC3L2	19	45728158	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	1505183	45728158	13400825	68	493											
LILRB2	10288	broad.mit.edu	37	chr19	54783691	54783691	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgagctcagaccaccgagCgcggctgtaatactgacagc	11	13	1	3			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:54783691C>T	uc002qfb.2	-	4	576	c.310G>A	c.(310-312)GCT>ACT	p.A104T	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.A104T|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.A104T|LILRB2_uc010yet.1_5'UTR|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	104	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACCACCGAGCGCGGCTGTAA	0.592													T	54783691	T	T	54783691	3	4	7	1	0	0	0	0	1	0	0	0	8791	768	27	1	1530	1	LILRB2	19	54783691	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	9055533	54783691	4345292	69	494											
KIR2DL3	3804	broad.mit.edu	37	chr19	55255258	55255260	+	In_Frame_Del	DEL	CTT	-	-													tccaggtctatatgagaaacCttctctctcagcccagccgg							TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr19:55255258_55255260delCTT	uc002qgv.2	+	4	404_406	c.386_388delCTT	c.(385-390)CCTTCT>CCT	p.S130del	KIR2DL3_uc002qgx.2_In_Frame_Del_p.S130del|KIR2DL3_uc002qgy.2_Intron|KIR2DL3_uc010erw.1_In_Frame_Del_p.S130del|KIR2DL1_uc002qgz.1_In_Frame_Del_p.S40del|KIR2DL3_uc002qha.1_Intron	NM_015868	NP_056952	P43628	KI2L3_HUMAN	killer cell immunoglobulin-like receptor, two	130	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	antigen binding|protein binding|receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		TATGAGAAACCTTCTCTCTCAGC	0.562													-	55255260	-	-	55255258	7	5	7	1	0	1	0	1	0	0	0	0	8317	681	24	0	400	0	KIR2DL3	19	55255258	In_Frame_Del	DEL	CTT	TCGA-02-2485-01A-01D-1494-08	471567	55255258	3873725	70	495											
SLCO4A1	28231	broad.mit.edu	37	chr20	61299253	61299253	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccacggagacgaatgtggaCggccagaaggtgagtggagc	18	8	0	3	rs138089582	byFrequency	TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr20:61299253C>T	uc002ydb.1	+	8	1834	c.1629C>T	c.(1627-1629)GAC>GAT	p.D543D	SLCO4A1_uc002ydc.1_RNA|LOC100127888_uc002ydd.2_5'Flank|SLCO4A1_uc002yde.1_Missense_Mutation_p.T3M	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	543	Extracellular (Potential).|Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CGAATGTGGACGGCCAGAAGG	0.647													T	61299253	T	T	61299253	2	4	7	1	0	0	0	0	0	0	0	1	14729	535	19	1		1	SLCO4A1	20	61299253	Silent	SNP	C	TCGA-02-2485-01A-01D-1494-08		61299253	1726267	71	496											
KIAA1644	85352	broad.mit.edu	37	chr22	44692617	44692617	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgcctggaactccgtctcGttgcagcagtatttgaagac	10	12	1	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chr22:44692617G>A	uc003bet.2	-	3	349	c.216C>T	c.(214-216)AAC>AAT	p.N72N		NM_001099294	NP_001092764	Q3SXP7	K1644_HUMAN	hypothetical protein LOC85352 precursor	72	Extracellular (Potential).					integral to membrane				ovary(1)	1		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				ACTCCGTCTCGTTGCAGCAGT	0.582													A	44692617	A	A	44692617	2	1	7	1	0	0	0	0	0	0	0	1	8250	1136	40	1		1	KIAA1644	22	44692617	Silent	SNP	G	TCGA-02-2485-01A-01D-1494-08		44692617	6611949	72	497											
PRPS2	5634	broad.mit.edu	37	chrX	12828240	12828240	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggaagaactgtatcattgttTcacctgacgcagggggagcc	13	9	2	2			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chrX:12828240T>A	uc004cvb.2	+	4	629	c.505T>A	c.(505-507)TCA>ACA	p.S169T	PRPS2_uc004cva.2_Missense_Mutation_p.S172T|PRPS2_uc010nec.2_Missense_Mutation_p.S105T	NM_002765	NP_002756	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	169					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity				0						TATCATTGTTTCACCTGACGC	0.463													A	12828240	A	A	12828240	3	1	7	1	0	0	0	0	1	0	0	0	12580	1783	62	5	528	5	PRPS2	23	12828240	Missense_Mutation	SNP	T	TCGA-02-2485-01A-01D-1494-08		12828240	142442320	73	498											
MSN	4478	broad.mit.edu	37	chrX	64949532	64949532	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgacttcaataaggaagtgcAtaagtctggctacctggccg	11	10	2	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chrX:64949532A>G	uc004dwf.2	+	4	623	c.425A>G	c.(424-426)CAT>CGT	p.H142R		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	142	FERM.				leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						AAGGAAGTGCATAAGTCTGGC	0.562			T	ALK	ALCL								G	64949532	G	G	64949532	3	3	7	1	0	0	0	0	1	0	0	0	9885	217	8	4	439	4	MSN	23	64949532	Missense_Mutation	SNP	A	TCGA-02-2485-01A-01D-1494-08	52121292	64949532	90321028	74	499											
HEPH	9843	broad.mit.edu	37	chrX	65486458	65486458	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcgacagagaaagctacgaCgcaataggaggtccatcctg	11	10	0	1			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chrX:65486458C>T	uc011moz.1	+	21	3490	c.3430C>T	c.(3430-3432)CGC>TGC	p.R1144C	HEPH_uc004dwn.2_Missense_Mutation_p.R1143C|HEPH_uc004dwo.2_Missense_Mutation_p.R874C|HEPH_uc010nkr.2_Missense_Mutation_p.R952C|HEPH_uc011mpa.1_Missense_Mutation_p.R1144C	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1141	Cytoplasmic (Potential).				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AAAGCTACGACGCAATAGGAG	0.498													T	65486458	T	T	65486458	3	4	7	1	0	0	0	0	1	0	0	0	7054	536	19	1	3665	1	HEPH	23	65486458	Missense_Mutation	SNP	C	TCGA-02-2485-01A-01D-1494-08	536926	65486458	89784102	75	500											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299891	125299891	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctttccgtttcctgctacctGtttgctgctgggccatggtg	11	12	0	0			TCGA-02-2485-01A-01D-1494-08	TCGA-02-2485-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	0332b017-17d5-4083-8fc4-9d6f8fdbbbde	8faa4b6d-6c64-4c03-bb3d-e2d33db491b0	g.chrX:125299891G>T	uc004euk.1	-	1	44	c.17C>A	c.(16-18)ACA>AAA	p.T6K		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	6										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CCTGCTACCTGTTTGCTGCTG	0.512													T	125299891	T	T	125299891	3	4	7	1	0	0	0	0	1	0	0	0	4265	1377	48	5	1378	5	DCAF12L2	23	125299891	Missense_Mutation	SNP	G	TCGA-02-2485-01A-01D-1494-08	59813433	125299891	29970669	76	501											
LOC649330	649330	broad.mit.edu	37	chr1	12907709	12907709	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtttcctgatagacgttgaCgtttcgagggcactacagcc	11	10	0	3	rs4026148		TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr1:12907709C>T	uc009vno.2	-	1	529	c.434G>A	c.(433-435)CGC>CAC	p.R145H	HNRNPCL1_uc010obf.1_Missense_Mutation_p.R145H	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	145							nucleic acid binding|nucleotide binding				0						TAGACGTTGACGTTTCGAGGG	0.483													T	12907709	T	T	12907709	3	4	8	1	0	0	0	0	1	0	0	0	8885	536	19	1	451	1	LOC649330	1	12907709	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		12907709	236342912	1	502											
LOC649330	649330	broad.mit.edu	37	chr1	12907886	12907886	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcggttcacttttggctctGcagccaggttaatatctaca	8	11	3	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr1:12907886G>A	uc009vno.2	-	1	352	c.257C>T	c.(256-258)GCA>GTA	p.A86V	HNRNPCL1_uc010obf.1_Missense_Mutation_p.A86V	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	86							nucleic acid binding|nucleotide binding				0						TTTTGGCTCTGCAGCCAGGTT	0.488													A	12907886	A	A	12907886	3	1	8	1	0	0	0	0	1	0	0	0	8885	1319	46	3	628	3	LOC649330	1	12907886	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	177	12907886	236342735	2	503											
HSPG2	3339	broad.mit.edu	37	chr1	22216489	22216489	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcacctgtgcccaggcgtcGgaactggaatccctggggag	14	13	1	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr1:22216489G>A	uc001bfj.2	-	6	599	c.559C>T	c.(559-561)CGA>TGA	p.R187*	HSPG2_uc009vqd.2_Nonsense_Mutation_p.R187*|HSPG2_uc009vqe.1_Silent_p.S85S	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	187	SEA.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCCAGGCGTCGGAACTGGAAT	0.488													A	22216489	A	A	22216489	4	1	8	1	0	0	0	0	0	1	0	0	7430	1124	39	2	12984	2	HSPG2	1	22216489	Nonsense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	9308603	22216489	227034132	3	504											
SLC2A1	6513	broad.mit.edu	37	chr1	43396355	43396355	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagggtgcccagggccccaCgaagggctgtgggtgacact	17	12	0	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr1:43396355C>T	uc001cik.2	-	4	983	c.458G>A	c.(457-459)CGT>CAT	p.R153H		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	153	Cytoplasmic (Potential).		R -> H (in GLUT1DS2).|R -> C (in GLUT1DS1; 44% of wild-type glucose uptake activity).		carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CAGGGCCCCACGAAGGGCTGT	0.647													T	43396355	T	T	43396355	3	4	8	1	0	0	0	0	1	0	0	0	14538	536	19	1	1048	1	SLC2A1	1	43396355	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	21179866	43396355	205854266	4	505											
CDKN2C	1031	broad.mit.edu	37	chr1	51439609	51439610	+	Frame_Shift_Ins	INS	-	A	A													ttgccaggagactgctacttINSagaggtgctaatcccgattt							TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr1:51439609_51439610insA	uc001csf.2	+	3	1390_1391	c.174_175insA	c.(172-177)CTTAGAfs	p.L58fs	CDKN2C_uc001csg.2_Frame_Shift_Ins_p.L58fs	NM_001262	NP_001253	P42773	CDN2C_HUMAN	cyclin-dependent kinase inhibitor 2C	58_59	ANK 2.				cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0?(4)|p.?(1)		central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(5)|ovary(2)|thyroid(1)|lung(1)|kidney(1)	17				GBM - Glioblastoma multiforme(3;3.61e-13)|all cancers(3;0.00151)		GACTGCTACTTAGAGGTGCTAA	0.441			D		glioma|MM				Multiple_Endocrine_Neoplasia_type_1				A	51439610	A	A	51439609	7	5	8	1	0	1	1	0	0	0	0	0	3165	1741	61	0	180	0	CDKN2C	1	51439609	Frame_Shift_Ins	INS	-	TCGA-02-2486-01A-01D-1494-08	8043254	51439609	197811012	5	506											
GPR52	9293	broad.mit.edu	37	chr1	174417940	174417940	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccacattttcaaaatttgcCgtcagcacaccaaagagata	5	11	2	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr1:174417940C>T	uc001gka.1	+	1	729	c.691C>T	c.(691-693)CGT>TGT	p.R231C	RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjx.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_Intron|uc010pmu.1_RNA	NM_005684	NP_005675	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	231	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1						CAAAATTTGCCGTCAGCACAC	0.463													T	174417940	T	T	174417940	3	4	8	1	0	0	0	0	1	0	0	0	6698	652	23	2	693	2	GPR52	1	174417940	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	122978331	174417940	74832681	6	507											
KIF21B	23046	broad.mit.edu	37	chr1	200974537	200974537	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggtgctggctgtggtgcGggacagggccccctgcttca	17	12	1	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr1:200974537G>A	uc001gvs.1	-	5	948	c.631C>T	c.(631-633)CGC>TGC	p.R211C	KIF21B_uc001gvr.1_Missense_Mutation_p.R211C|KIF21B_uc009wzl.1_Missense_Mutation_p.R211C|KIF21B_uc010ppn.1_Missense_Mutation_p.R211C|KIF21B_uc001gvt.1_5'UTR	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	211	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GCTGTGGTGCGGGACAGGGCC	0.627													A	200974537	A	A	200974537	3	1	8	1	0	0	0	0	1	0	0	0	8289	1116	39	2	4363	2	KIF21B	1	200974537	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	26556597	200974537	48276084	7	508											
OR2T4	127074	broad.mit.edu	37	chr1	248525343	248525343	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccaccatggcctatgaccGctacgtggccatctgccatc	9	16	1	1	rs141022739		TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr1:248525343G>A	uc001ieh.1	+	1	461	c.461G>A	c.(460-462)CGC>CAC	p.R154H		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	154	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCTATGACCGCTACGTGGCC	0.522													A	248525343	A	A	248525343	3	1	8	1	0	0	0	0	1	0	0	0	11027	1087	38	1	463	1	OR2T4	1	248525343	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	47550806	248525343	725278	8	509											
CAD	790	broad.mit.edu	37	chr2	27446562	27446562	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgggctcctctcttcaccaAcgccaatgatggttccaatg	8	14	2	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr2:27446562A>G	uc002rji.2	+	7	1103	c.941A>G	c.(940-942)AAC>AGC	p.N314S	CAD_uc010eyw.2_Missense_Mutation_p.N314S	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	314	Glutamine amidotransferase type-1.|GATase (Glutamine amidotransferase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CTCTTCACCAACGCCAATGAT	0.537													G	27446562	G	G	27446562	3	3	8	1	0	0	0	0	1	0	0	0	2565	43	2	4	967	4	CAD	2	27446562	Missense_Mutation	SNP	A	TCGA-02-2486-01A-01D-1494-08		27446562	215752811	9	510											
RHOQ	23433	broad.mit.edu	37	chr2	46803312	46803312	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtggtaaatccagcctcattTcaaaatgtgaaagaggagtg	11	6	2	2			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr2:46803312T>A	uc002rva.2	+	3	607	c.288T>A	c.(286-288)TTT>TTA	p.F96L	uc002rvb.2_Intron	NM_012249	NP_036381	P17081	RHOQ_HUMAN	ras-like protein TC10 precursor	96					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CAGCCTCATTTCAAAATGTGA	0.418													A	46803312	A	A	46803312	3	1	8	1	0	0	0	0	1	0	0	0	13342	1780	62	5	298	5	RHOQ	2	46803312	Missense_Mutation	SNP	T	TCGA-02-2486-01A-01D-1494-08	19356750	46803312	196396061	10	511											
LRP2	4036	broad.mit.edu	37	chr2	170060768	170060768	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacgcccgtcagagtgctgcGttcaatcctctgcctaaaat	8	14	3	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr2:170060768G>A	uc002ues.2	-	42	7942	c.7729C>T	c.(7729-7731)CGC>TGC	p.R2577C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2577	LDL-receptor class B 28.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGAGTGCTGCGTTCAATCCTC	0.433													A	170060768	A	A	170060768	3	1	8	1	0	0	0	0	1	0	0	0	8956	1145	40	1	6390	1	LRP2	2	170060768	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	123257456	170060768	73138605	11	512											
SCN10A	6336	broad.mit.edu	37	chr3	38739171	38739171	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaatgtcttcttgcttccatCggagagtggttgctattggt	11	7	2	1	rs148537653		TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr3:38739171C>T	uc003ciq.2	-	27	5540	c.5540G>A	c.(5539-5541)CGA>CAA	p.R1847Q		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1847					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTGCTTCCATCGGAGAGTGGT	0.473													T	38739171	T	T	38739171	3	4	8	1	0	0	0	0	1	0	0	0	13912	884	31	2	334	2	SCN10A	3	38739171	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		38739171	159283259	12	513											
CCBP2	1238	broad.mit.edu	37	chr3	42906816	42906816	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaccttgtttctgcatacGctgttggacctgcaagtatt	8	11	2	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr3:42906816G>A	uc003cme.2	+	3	1001	c.822G>A	c.(820-822)ACG>ACA	p.T274T	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmf.2_Silent_p.T274T|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	274	Extracellular (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		TTCTGCATACGCTGTTGGACC	0.537													A	42906816	A	A	42906816	2	1	8	1	0	0	0	0	0	0	0	1	2734	1074	38	1		1	CCBP2	3	42906816	Silent	SNP	G	TCGA-02-2486-01A-01D-1494-08	4167645	42906816	155115614	13	514											
PLXNB1	5364	broad.mit.edu	37	chr3	48463528	48463528	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgacctgccaaggagcacGcaccacccacagtatgggtc	10	15	1	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr3:48463528G>A	uc003csw.2	-	6	1776	c.1506C>T	c.(1504-1506)TGC>TGT	p.C502C	PLXNB1_uc003csu.2_Silent_p.C502C|PLXNB1_uc003csx.2_Silent_p.C502C|PLXNB1_uc010hjx.1_RNA	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	502	Extracellular (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CAAGGAGCACGCACCACCCAC	0.557													A	48463528	A	A	48463528	2	1	8	1	0	0	0	0	0	0	0	1	12123	1079	38	1		1	PLXNB1	3	48463528	Silent	SNP	G	TCGA-02-2486-01A-01D-1494-08	5556712	48463528	149558902	14	515											
SOX14	8403	broad.mit.edu	37	chr3	137484152	137484152	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctgggctaccagaacggcGccttcggcagcctcagctgc	12	17	1	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr3:137484152G>A	uc003erm.1	+	1	574	c.526G>A	c.(526-528)GCC>ACC	p.A176T		NM_004189	NP_004180	O95416	SOX14_HUMAN	SRY-box 14	176					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding				0						CCAGAACGGCGCCTTCGGCAG	0.667													A	137484152	A	A	137484152	3	1	8	1	0	0	0	0	1	0	0	0	14945	1087	38	1	528	1	SOX14	3	137484152	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	89020624	137484152	60538278	15	516											
ATR	545	broad.mit.edu	37	chr3	142183989	142183989	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tctacaatcctttctcaggtCatcttttggcttacacatca	4	12	5	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr3:142183989C>A	uc003eux.3	-	41	7113	c.6991G>T	c.(6991-6993)GAC>TAC	p.D2331Y	ATR_uc003euy.1_Missense_Mutation_p.D217Y	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2331	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TTTCTCAGGTCATCTTTTGGC	0.299								Other_conserved_DNA_damage_response_genes					A	142183989	A	A	142183989	3	1	8	1	0	0	0	0	1	0	0	0	1204	826	29	5	971	5	ATR	3	142183989	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	4699837	142183989	55838441	16	517											
NSUN7	79730	broad.mit.edu	37	chr4	40800851	40800851	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gcacatgttcagtttttccaGaagaaaatgaagctgttgtt	9	6	1	3			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr4:40800851G>T	uc003gvj.3	+	10	1825	c.1330G>T	c.(1330-1332)GAA>TAA	p.E444*	NSUN7_uc003gvi.3_Nonsense_Mutation_p.E444*	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						AGTTTTTCCAGAAGAAAATGA	0.343													T	40800851	T	T	40800851	4	4	8	1	0	0	0	0	0	1	0	0	10683	943	33	5	1364	5	NSUN7	4	40800851	Nonsense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08		40800851	150353425	17	518											
NPY5R	4889	broad.mit.edu	37	chr4	164271493	164271493	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaataatactgctgccactcGgaattctgatttcccagtct	7	11	2	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr4:164271493G>A	uc003iqn.2	+	4	250	c.68G>A	c.(67-69)CGG>CAG	p.R23Q		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	23	Extracellular (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				GCTGCCACTCGGAATTCTGAT	0.378													A	164271493	A	A	164271493	3	1	8	1	0	0	0	0	1	0	0	0	10610	1116	39	2	70	2	NPY5R	4	164271493	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	123470642	164271493	26882783	18	519											
ADAM29	11086	broad.mit.edu	37	chr4	175897289	175897289	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggattgttgaaattgtagtcGtcattgataattatctgtac	9	4	2	2			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr4:175897289G>A	uc003iuc.2	+	5	1283	c.613G>A	c.(613-615)GTC>ATC	p.V205I	ADAM29_uc003iud.2_Missense_Mutation_p.V205I|ADAM29_uc010irr.2_Missense_Mutation_p.V205I|ADAM29_uc011cki.1_Missense_Mutation_p.V205I	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	205	Peptidase M12B.|Extracellular (Potential).		V -> I (in a colorectal cancer sample; somatic mutation).		proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding	p.V205I(1)		skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AATTGTAGTCGTCATTGATAA	0.348													A	175897289	A	A	175897289	3	1	8	1	0	0	0	0	1	0	0	0	247	1145	40	1	615	1	ADAM29	4	175897289	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	11625796	175897289	15256987	19	520											
IL31RA	133396	broad.mit.edu	37	chr5	55206410	55206410	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggcctggagtccctgaaaCgaaagacctcttacattgtt	9	11	1	2			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr5:55206410C>T	uc003jql.2	+	12	1617	c.1552C>T	c.(1552-1554)CGA>TGA	p.R518*	IL31RA_uc003jqm.2_Nonsense_Mutation_p.R486*|IL31RA_uc003jqn.2_Nonsense_Mutation_p.R518*|IL31RA_uc010iwa.1_Nonsense_Mutation_p.R481*|IL31RA_uc003jqo.2_Nonsense_Mutation_p.R376*	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	486	Extracellular (Potential).|Fibronectin type-III 5.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GTCCCTGAAACGAAAGACCTC	0.458													T	55206410	T	T	55206410	4	4	8	1	0	0	0	0	0	1	0	0	7691	528	19	1	1598	1	IL31RA	5	55206410	Nonsense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		55206410	125708850	20	521											
GABRB2	2561	broad.mit.edu	37	chr5	160721153	160721153	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaccactgggaagaatatgcGggaccaccgatctatggcat	11	10	1	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr5:160721153G>A	uc003lys.1	-	11	1692	c.1474C>T	c.(1474-1476)CGC>TGC	p.R492C	GABRB2_uc011deh.1_Missense_Mutation_p.R293C|GABRB2_uc003lyr.1_Missense_Mutation_p.R454C|GABRB2_uc003lyt.1_Missense_Mutation_p.R454C|GABRB2_uc010jiu.1_Missense_Mutation_p.R391C	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	492	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AAGAATATGCGGGACCACCGA	0.468													A	160721153	A	A	160721153	3	1	8	1	0	0	0	0	1	0	0	0	6167	1116	39	2	68	2	GABRB2	5	160721153	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	105514743	160721153	20194107	21	522											
GABRA6	2559	broad.mit.edu	37	chr5	161113291	161113291	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaacttctactcagaaaacGtcagtcggatcctggacaac	8	12	3	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr5:161113291G>T	uc003lyu.2	+	2	432	c.94G>T	c.(94-96)GTC>TTC	p.V32F		NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	32	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTCAGAAAACGTCAGTCGGAT	0.488										TCGA Ovarian(5;0.080)			T	161113291	T	T	161113291	3	4	8	1	0	0	0	0	1	0	0	0	6165	1145	40	5	100	5	GABRA6	5	161113291	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	392138	161113291	19801969	22	523											
GABRP	2568	broad.mit.edu	37	chr5	170222299	170222299	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagcttcactctggatgccCgcctcgtggagttcctctgg	12	13	3	1	rs145233692		TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr5:170222299C>T	uc003mau.2	+	5	526	c.328C>T	c.(328-330)CGC>TGC	p.R110C	GABRP_uc011dev.1_Missense_Mutation_p.R110C	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	110	Extracellular (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTGGATGCCCGCCTCGTGGA	0.562													T	170222299	T	T	170222299	3	4	8	1	0	0	0	0	1	0	0	0	6174	652	23	2	342	2	GABRP	5	170222299	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	9109008	170222299	10692961	23	524											
HRH2	3274	broad.mit.edu	37	chr5	175110333	175110333	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggtcctcatcctcatcaccGttgctggcaatgtggtcgtc	10	14	3	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr5:175110333G>A	uc003mdd.2	+	1	1870	c.97G>A	c.(97-99)GTT>ATT	p.V33I	HRH2_uc003mdc.3_Missense_Mutation_p.V33I	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	33	Helical; Name=1; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CCTCATCACCGTTGCTGGCAA	0.572													A	175110333	A	A	175110333	3	1	8	1	0	0	0	0	1	0	0	0	7356	1145	40	1	99	1	HRH2	5	175110333	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	4888034	175110333	5804927	24	525											
C6orf15	29113	broad.mit.edu	37	chr6	31079167	31079167	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctatcgtgctctagccccaCtgcaacctagggcttggagg	11	13	2	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr6:31079167C>A	uc003nsk.1	-	2	969	c.969G>T	c.(967-969)CAG>CAT	p.Q323H		NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	323											0						TCTAGCCCCACTGCAACCTAG	0.562													A	31079167	A	A	31079167	3	1	8	1	0	0	0	0	1	0	0	0	2336	564	20	5	12	5	C6orf15	6	31079167	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		31079167	140035900	25	526											
KCNQ5	56479	broad.mit.edu	37	chr6	73787150	73787150	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtttcctacagatcctccGcatggtgcgcatggaccgaa	10	14	0	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr6:73787150G>A	uc003pgk.2	+	4	1069	c.722G>A	c.(721-723)CGC>CAC	p.R241H	KCNQ5_uc003pgj.3_Missense_Mutation_p.R241H|KCNQ5_uc011dyh.1_Missense_Mutation_p.R241H|KCNQ5_uc011dyi.1_Missense_Mutation_p.R241H|KCNQ5_uc010kat.2_Missense_Mutation_p.R241H|KCNQ5_uc011dyj.1_Missense_Mutation_p.R241H|KCNQ5_uc011dyk.1_5'UTR	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	241	Helical; Voltage-sensor; Name=Segment S4; (Potential).				protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity	p.R241H(1)		ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CAGATCCTCCGCATGGTGCGC	0.443													A	73787150	A	A	73787150	3	1	8	1	0	0	0	0	1	0	0	0	8086	1087	38	1	736	1	KCNQ5	6	73787150	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	42707983	73787150	97327917	26	527											
PRDM13	59336	broad.mit.edu	37	chr6	100062050	100062050	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaagccccgccgagctgggGtcgctggccagcatcgaccg	14	16	0	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr6:100062050G>A	uc003pqg.1	+	4	1800	c.1539G>A	c.(1537-1539)GGG>GGA	p.G513G		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	513					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		CCGAGCTGGGGTCGCTGGCCA	0.662													A	100062050	A	A	100062050	2	1	8	1	0	0	0	0	0	0	0	1	12454	1248	44	3		3	PRDM13	6	100062050	Silent	SNP	G	TCGA-02-2486-01A-01D-1494-08	26274900	100062050	71053017	27	528											
BEND3	57673	broad.mit.edu	37	chr6	107391831	107391831	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaagtagatgttggggtcGttgtcagtgcctgccccggt	16	8	1	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr6:107391831G>A	uc003prs.2	-	5	1214	c.564C>T	c.(562-564)AAC>AAT	p.N188N		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	188										ovary(3)	3						TGTTGGGGTCGTTGTCAGTGC	0.577													A	107391831	A	A	107391831	2	1	8	1	0	0	0	0	0	0	0	1	1399	1136	40	1		1	BEND3	6	107391831	Silent	SNP	G	TCGA-02-2486-01A-01D-1494-08	7329781	107391831	63723236	28	529											
SGK1	6446	broad.mit.edu	37	chr6	134492161	134492161	+	Frame_Shift_Del	DEL	G	-	-													gacaggaaaacatcactcacGaagtcatccttggccccgag							TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr6:134492161delG	uc003qen.3	-	10	1127	c.1038delC	c.(1036-1038)TTCfs	p.F346fs	SGK1_uc003qeo.3_Frame_Shift_Del_p.F441fs|SGK1_uc011ect.1_Frame_Shift_Del_p.F336fs|SGK1_uc011ecu.1_Frame_Shift_Del_p.F302fs|SGK1_uc011ecv.1_Frame_Shift_Del_p.F360fs|SGK1_uc011ecw.1_Frame_Shift_Del_p.F374fs	NM_005627	NP_005618	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1 isoform	346	Protein kinase.				apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(3)|stomach(1)|lung(1)|central_nervous_system(1)	6	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		CATCACTCACGAAGTCATCCT	0.527													-	134492161	-	-	134492161	7	5	8	1	0	1	0	1	0	0	0	0	14207	1072	37	0	269	0	SGK1	6	134492161	Frame_Shift_Del	DEL	G	TCGA-02-2486-01A-01D-1494-08	27100330	134492161	36622906	29	530											
KIAA1244	57221	broad.mit.edu	37	chr6	138612912	138612912	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggagcacaaccacttcagCgatggtgcctcgcagccccc	10	17	1	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr6:138612912C>T	uc003qhu.2	+	19	3090	c.3090C>T	c.(3088-3090)AGC>AGT	p.S1030S		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1030					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ACCACTTCAGCGATGGTGCCT	0.647													T	138612912	T	T	138612912	2	4	8	1	0	0	0	0	0	0	0	1	8217	767	27	1		1	KIAA1244	6	138612912	Silent	SNP	C	TCGA-02-2486-01A-01D-1494-08	4120751	138612912	32502155	30	531											
DNAH11	8701	broad.mit.edu	37	chr7	21583201	21583201	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccgcctcggggcgccttgCggcttcccaggaggtaagag	16	14	0	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr7:21583201C>T	uc003svc.2	+	1	369	c.338C>T	c.(337-339)GCG>GTG	p.A113V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	113	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGGCGCCTTGCGGCTTCCCAG	0.617									Kartagener_syndrome				T	21583201	T	T	21583201	3	4	8	1	0	0	0	0	1	0	0	0	4599	768	27	1	340	1	DNAH11	7	21583201	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		21583201	137555462	31	532											
STK31	56164	broad.mit.edu	37	chr7	23802525	23802525	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgagtcatctcttaataaaCgcttaaaaacattgcaggtt	6	7	2	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr7:23802525C>T	uc003sws.3	+	11	1466	c.1399C>T	c.(1399-1401)CGC>TGC	p.R467C	STK31_uc003swt.3_Missense_Mutation_p.R444C|STK31_uc011jze.1_Missense_Mutation_p.R467C|STK31_uc010kuq.2_Missense_Mutation_p.R444C	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	467							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TCTTAATAAACGCTTAAAAAC	0.289													T	23802525	T	T	23802525	3	4	8	1	0	0	0	0	1	0	0	0	15295	536	19	1	1441	1	STK31	7	23802525	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	2219324	23802525	135336138	32	533											
TXNDC3	51314	broad.mit.edu	37	chr7	37923916	37923916	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttatttagatgatgttttgCgtattattaaagatgaagac	8	2	0	5			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr7:37923916C>T	uc003tfn.2	+	13	1378	c.1006C>T	c.(1006-1008)CGT>TGT	p.R336C		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	336	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TGATGTTTTGCGTATTATTAA	0.303									Kartagener_syndrome				T	37923916	T	T	37923916	3	4	8	1	0	0	0	0	1	0	0	0	16795	768	27	1	1048	1	TXNDC3	7	37923916	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	14121391	37923916	121214747	33	534											
HECW1	23072	broad.mit.edu	37	chr7	43360248	43360248	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atatagatgaggtcttgtccGaaaactttctggactataaa	8	6	2	2			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr7:43360248G>A	uc003tid.1	+	5	972	c.367G>A	c.(367-369)GAA>AAA	p.E123K	HECW1_uc011kbi.1_Missense_Mutation_p.E123K|HECW1_uc003tie.1_Missense_Mutation_p.E155K	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	123					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GGTCTTGTCCGAAAACTTTCT	0.428													A	43360248	A	A	43360248	3	1	8	1	0	0	0	0	1	0	0	0	7042	1059	37	2	377	2	HECW1	7	43360248	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	5436332	43360248	115778415	34	535											
SRCRB4D	136853	broad.mit.edu	37	chr7	76019569	76019569	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggccacagcccagctggCggcacaggacaccggctgcc	13	18	0	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr7:76019569C>T	uc003ufb.2	-	11	1883	c.1535G>A	c.(1534-1536)CGC>CAC	p.R512H	SRCRB4D_uc003ufa.2_Missense_Mutation_p.A14T	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	512	SRCR 4.					extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						GCCCAGCTGGCGGCACAGGAC	0.667													T	76019569	T	T	76019569	3	4	8	1	0	0	0	0	1	0	0	0	15136	768	27	1	196	1	SRCRB4D	7	76019569	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	32659321	76019569	83119094	35	536											
KIAA1324L	222223	broad.mit.edu	37	chr7	86521158	86521158	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagccgggagttcacacTcttttgagttagtcgtcatt	10	10	3	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr7:86521158T>A	uc011kha.1	-	21	3097	c.2912A>T	c.(2911-2913)GAG>GTG	p.E971V	KIAA1324L_uc003uif.1_Missense_Mutation_p.E731V|KIAA1324L_uc011kgz.1_Missense_Mutation_p.E857V|KIAA1324L_uc003uie.2_Missense_Mutation_p.E804V	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	971	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					GAGTTCACACTCTTTTGAGTT	0.323													A	86521158	A	A	86521158	3	1	8	1	0	0	0	0	1	0	0	0	8224	1551	54	5	185	5	KIAA1324L	7	86521158	Missense_Mutation	SNP	T	TCGA-02-2486-01A-01D-1494-08	10501589	86521158	72617505	36	537											
MCM7	4176	broad.mit.edu	37	chr7	99693629	99693629	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacctcgtggatggctgtgcGgtcggcctcagccatcttgt	14	12	2	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr7:99693629G>A	uc003usw.1	-	11	1873	c.1363C>T	c.(1363-1365)CGC>TGC	p.R455C	MCM7_uc003usv.1_Missense_Mutation_p.R279C|MCM7_uc003usx.1_Missense_Mutation_p.R279C|uc003usy.1_5'Flank|MIR25_hsa-mir-25|MI0000082_5'Flank|uc003usz.1_5'Flank|MIR93_hsa-mir-93|MI0000095_5'Flank|uc003uta.1_5'Flank|MIR106B_hsa-mir-106b|MI0000734_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	455	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	ATGGCTGTGCGGTCGGCCTCA	0.612													A	99693629	A	A	99693629	3	1	8	1	0	0	0	0	1	0	0	0	9392	1116	39	2	816	2	MCM7	7	99693629	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	13172471	99693629	59445034	37	538											
CPA2	1358	broad.mit.edu	37	chr7	129909521	129909521	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctttcagcttgatttttggAaatcacccaccaccccaggg	7	14	2	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr7:129909521A>G	uc003vpq.2	+	3	185	c.166A>G	c.(166-168)AAA>GAA	p.K56E	CPA2_uc011kpc.1_Missense_Mutation_p.K56E	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	56					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TGATTTTTGGAAATCACCCAC	0.493													G	129909521	G	G	129909521	3	3	8	1	0	0	0	0	1	0	0	0	3790	247	9	4	176	4	CPA2	7	129909521	Missense_Mutation	SNP	A	TCGA-02-2486-01A-01D-1494-08	30215892	129909521	29229142	38	539											
NOS3	4846	broad.mit.edu	37	chr7	150699008	150699008	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accggccgggcccagagctaCgcacagcagctggggagact	15	14	0	2			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr7:150699008C>T	uc003wif.2	+	13	1898	c.1602C>T	c.(1600-1602)TAC>TAT	p.Y534Y	NOS3_uc011kuy.1_Silent_p.Y328Y|NOS3_uc011kuz.1_Silent_p.Y534Y|NOS3_uc011kva.1_Silent_p.Y534Y|NOS3_uc011kvb.1_Silent_p.Y534Y	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	534	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCCAGAGCTACGCACAGCAGC	0.637													T	150699008	T	T	150699008	2	4	8	1	0	0	0	0	0	0	0	1	10544	547	19	1		1	NOS3	7	150699008	Silent	SNP	C	TCGA-02-2486-01A-01D-1494-08	20789487	150699008	8439655	39	540											
GFRA2	2675	broad.mit.edu	37	chr8	21608207	21608207	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttgccggcggcgctcagcGcacgcctggtcttggcagga	16	13	2	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr8:21608207G>A	uc003wzu.1	-	4	1362	c.687C>T	c.(685-687)TGC>TGT	p.C229C	GFRA2_uc003wzv.1_Silent_p.C124C|GFRA2_uc003wzw.1_Silent_p.C96C|DOK2_uc003wzx.1_Intron	NM_001495	NP_001486	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2 isoform a	229						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity				0				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		GGCGCTCAGCGCACGCCTGGT	0.657													A	21608207	A	A	21608207	2	1	8	1	0	0	0	0	0	0	0	1	6348	1079	38	1		1	GFRA2	8	21608207	Silent	SNP	G	TCGA-02-2486-01A-01D-1494-08		21608207	124755815	40	541											
FAM150A	389658	broad.mit.edu	37	chr8	53452429	53452429	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccctggtattgtaatagagtCggtggaaatgtttgctgcat	12	6	0	1	rs145116532		TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr8:53452429C>T	uc003xrd.2	-	3	492	c.287G>A	c.(286-288)CGA>CAA	p.R96Q	FAM150A_uc011ldt.1_Missense_Mutation_p.R96Q	NM_207413	NP_997296	Q6UXT8	F150A_HUMAN	hypothetical protein LOC389658 precursor	96						extracellular region					0		Lung NSC(129;0.0919)|all_epithelial(80;0.125)|all_lung(136;0.17)				GTAATAGAGTCGGTGGAAATG	0.363													T	53452429	T	T	53452429	3	4	8	1	0	0	0	0	1	0	0	0	5456	884	31	2	110	2	FAM150A	8	53452429	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	31844222	53452429	92911593	41	542											
CSMD3	114788	broad.mit.edu	37	chr8	114326801	114326801	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccattcaaaacacactaaccTtgtcctaaagtttgtaggat	5	10	1	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr8:114326801T>A	uc003ynu.2	-	2	559	c.400A>T	c.(400-402)AGG>TGG	p.R134W	CSMD3_uc003ynt.2_Missense_Mutation_p.R94W|CSMD3_uc011lhx.1_Missense_Mutation_p.R134W|CSMD3_uc010mcx.1_Missense_Mutation_p.R134W|CSMD3_uc003ynx.3_Missense_Mutation_p.R134W	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	134	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACACTAACCTTGTCCTAAAG	0.303										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			A	114326801	A	A	114326801	3	1	8	1	0	0	0	0	1	0	0	0	3946	1623	56	5	11003	5	CSMD3	8	114326801	Missense_Mutation	SNP	T	TCGA-02-2486-01A-01D-1494-08	60874372	114326801	32037221	42	543											
PTPN3	5774	broad.mit.edu	37	chr9	112185070	112185070	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctccactgataaggatctcCgcatggctgggttccacacc	10	14	1	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr9:112185070C>T	uc004bed.2	-	13	1176	c.1064G>A	c.(1063-1065)CGG>CAG	p.R355Q	PTPN3_uc004beb.2_Missense_Mutation_p.R224Q|PTPN3_uc004bec.2_Intron|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Intron|PTPN3_uc011lwh.1_Intron|PTPN3_uc011lwe.1_Missense_Mutation_p.R68Q|PTPN3_uc011lwf.1_Intron	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	355					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						TAAGGATCTCCGCATGGCTGG	0.453													T	112185070	T	T	112185070	3	4	8	1	0	0	0	0	1	0	0	0	12789	652	23	2	1733	2	PTPN3	9	112185070	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		112185070	29028361	43	544											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112900697	112900697	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	catgattgaggaagagatccGagcagctcaggaaagggaag	15	6	1	3	rs139808664		TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr9:112900697G>A	uc004bei.2	+	9	3761	c.3569G>A	c.(3568-3570)CGA>CAA	p.R1190Q	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.R958Q|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.R958Q|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.R768Q|AKAP2_uc011lwi.1_Missense_Mutation_p.R816Q|AKAP2_uc004bem.2_Missense_Mutation_p.R816Q|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.R776Q|AKAP2_uc011lwj.1_Missense_Mutation_p.R727Q|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.R727Q	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	727	Potential.						enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						GAAGAGATCCGAGCAGCTCAG	0.552													A	112900697	A	A	112900697	3	1	8	1	0	0	0	0	1	0	0	0	11410	1058	37	2	2903	2	PALM2-AKAP2	9	112900697	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	715627	112900697	28312734	44	545											
KIAA0649	9858	broad.mit.edu	37	chr9	138377609	138377609	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaaaagtgccttgcccgagaCccacaggaaaacacccagca	8	14	0	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr9:138377609C>A	uc004cfr.1	+	4	1802	c.1253C>A	c.(1252-1254)ACC>AAC	p.T418N		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	418						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		TTGCCCGAGACCCACAGGAAA	0.622													A	138377609	A	A	138377609	3	1	8	1	0	0	0	0	1	0	0	0	8187	507	18	5	1255	5	KIAA0649	9	138377609	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	25476912	138377609	2835822	45	546											
CRTAC1	55118	broad.mit.edu	37	chr10	99683092	99683092	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acgggccacgttgacctcatCgctcaggatgtcttcccacc	9	16	3	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr10:99683092C>T	uc001kou.1	-	4	843	c.487G>A	c.(487-489)GAT>AAT	p.D163N	CRTAC1_uc001kov.2_Missense_Mutation_p.D152N|CRTAC1_uc001kot.1_5'UTR	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	163						proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		TTGACCTCATCGCTCAGGATG	0.612													T	99683092	T	T	99683092	3	4	8	1	0	0	0	0	1	0	0	0	3896	884	31	2	1546	2	CRTAC1	10	99683092	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		99683092	35851655	46	547											
DEAF1	10522	broad.mit.edu	37	chr11	688025	688025	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttccacctttttcttggcCgggagccagaggggttggag	15	9	1	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr11:688025C>T	uc001lqq.1	-	4	1243	c.550G>A	c.(550-552)GGC>AGC	p.G184S	DEAF1_uc009ycf.1_RNA	NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	184					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		TTTTCTTGGCCGGGAGCCAGA	0.547													T	688025	T	T	688025	3	4	8	1	0	0	0	0	1	0	0	0	4380	652	23	2	1183	2	DEAF1	11	688025	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		688025	134318491	47	548											
OR51E1	143503	broad.mit.edu	37	chr11	4674216	4674216	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggtgtggctgctgtggtgCggggggctgcactgatggca	20	7	0	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr11:4674216C>T	uc001lzi.3	+	2	604	c.460C>T	c.(460-462)CGG>TGG	p.R154W		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTGTGGTGCGGGGGGCTGC	0.557													T	4674216	T	T	4674216	3	4	8	1	0	0	0	0	1	0	0	0	11094	759	27	1	462	1	OR51E1	11	4674216	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	3986191	4674216	130332300	48	549											
OR2AG1	144125	broad.mit.edu	37	chr11	6807033	6807033	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggatgttctatggagctgcCacattcatgtatgtcttgcc	11	9	3	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr11:6807033C>G	uc001mer.1	+	1	765	c.765C>G	c.(763-765)GCC>GCG	p.A255A		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATGGAGCTGCCACATTCATGT	0.488													G	6807033	G	G	6807033	2	3	8	1	0	0	0	0	0	0	0	1	10984	581	21	5		5	OR2AG1	11	6807033	Silent	SNP	C	TCGA-02-2486-01A-01D-1494-08	2132817	6807033	128199483	49	550											
OR4C12	283093	broad.mit.edu	37	chr11	50004010	50004010	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtaagacctattaaaatgaAttcagtcacattctttttct	4	7	4	2			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr11:50004010A>G	uc010ria.1	-	1	28	c.28T>C	c.(28-30)TTC>CTC	p.F10L		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ATTAAAATGAATTCAGTCACA	0.338													G	50004010	G	G	50004010	3	3	8	1	0	0	0	0	1	0	0	0	11046	101	4	4	905	4	OR4C12	11	50004010	Missense_Mutation	SNP	A	TCGA-02-2486-01A-01D-1494-08	43196977	50004010	85002506	50	551											
FIBP	9158	broad.mit.edu	37	chr11	65655866	65655866	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ataagggtcgtgttccccacGaagatgtccagctcactggt	11	11	1	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr11:65655866G>A	uc001ogd.2	-	1	145	c.24C>T	c.(22-24)TTC>TTT	p.F8F	FIBP_uc009yqu.2_Silent_p.F8F|FIBP_uc001oge.2_Silent_p.F8F|FIBP_uc010roq.1_Silent_p.F8F|FIBP_uc010ror.1_Silent_p.F8F|CCDC85B_uc001ogf.2_5'Flank	NM_198897	NP_942600	O43427	FIBP_HUMAN	FGF intracellular binding protein isoform a	8					fibroblast growth factor receptor signaling pathway	endomembrane system|membrane|microsome|mitochondrion|nucleus	fibroblast growth factor binding			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.166)		TGTTCCCCACGAAGATGTCCA	0.682											OREG0021090	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	65655866	A	A	65655866	2	1	8	1	0	0	0	0	0	0	0	1	5886	1049	37	2		2	FIBP	11	65655866	Silent	SNP	G	TCGA-02-2486-01A-01D-1494-08	15651856	65655866	69350650	51	552											
MMP1	4312	broad.mit.edu	37	chr11	102663439	102663439	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaaattgagctcaacttcCgggtagaagggatttgtgcg	13	6	1	3			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr11:102663439C>T	uc001phi.2	-	7	1073	c.930G>A	c.(928-930)CCG>CCA	p.P310P	uc001phh.1_Intron|MMP1_uc010ruv.1_Silent_p.P244P	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	310	Hemopexin-like 1.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		GCTCAACTTCCGGGTAGAAGG	0.423													T	102663439	T	T	102663439	2	4	8	1	0	0	0	0	0	0	0	1	9648	639	23	2		2	MMP1	11	102663439	Silent	SNP	C	TCGA-02-2486-01A-01D-1494-08	37007573	102663439	32343077	52	553											
OR8D4	338662	broad.mit.edu	37	chr11	123777647	123777647	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actcaggttgtctttctgtgGatcaaacatcattaaacatt	6	8	5	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr11:123777647G>A	uc010saa.1	+	1	509	c.509G>A	c.(508-510)GGA>GAA	p.G170E		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TCTTTCTGTGGATCAAACATC	0.418													A	123777647	A	A	123777647	3	1	8	1	0	0	0	0	1	0	0	0	11233	1174	41	3	511	3	OR8D4	11	123777647	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	21114208	123777647	11228869	53	554											
KCNMB4	27345	broad.mit.edu	37	chr12	70793987	70793987	+	Splice_Site	DEL	A	-	-													tttctgtattctattttgttAgtgctcctatatccctccct							TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr12:70793987delA	uc001svx.2	+	2	790	c.337_splice	c.e2-2	p.C113_splice		NM_014505	NP_055320	Q86W47	KCMB4_HUMAN	calcium-activated potassium channel beta 4						detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding				0	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			CTATTTTGTTAGTGCTCCTAT	0.333													-	70793987	-	-	70793987	8	5	8	1	0	1	0	1	0	0	1	0	8077	434	15	0	341	0	KCNMB4	12	70793987	Splice_Site	DEL	A	TCGA-02-2486-01A-01D-1494-08		70793987	63057908	54	555											
ANKS1B	56899	broad.mit.edu	37	chr12	100166859	100166859	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgataattctccagtgacGgtttcacctatgagaataat	7	7	2	3			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr12:100166859G>A	uc001tge.1	-	8	1386	c.969C>T	c.(967-969)ACC>ACT	p.T323T	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Silent_p.T289T	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	323						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CTCCAGTGACGGTTTCACCTA	0.323													A	100166859	A	A	100166859	2	1	8	1	0	0	0	0	0	0	0	1	689	1103	39	2		2	ANKS1B	12	100166859	Silent	SNP	G	TCGA-02-2486-01A-01D-1494-08	29372872	100166859	33685036	55	556											
KDM2B	84678	broad.mit.edu	37	chr12	121880300	121880300	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgggggccgcttgggctcctCgccctcgctctcaggctccg	14	18	1	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr12:121880300C>T	uc001uat.2	-	19	3048	c.2944G>A	c.(2944-2946)GAG>AAG	p.E982K	KDM2B_uc001uaq.2_Missense_Mutation_p.E422K|KDM2B_uc010szy.1_Missense_Mutation_p.E422K|KDM2B_uc001uar.2_Missense_Mutation_p.E573K|KDM2B_uc001uas.2_Missense_Mutation_p.E913K|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.E230K|KDM2B_uc010szx.1_Missense_Mutation_p.E230K|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	982					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						TTGGGCTCCTCGCCCTCGCTC	0.632													T	121880300	T	T	121880300	3	4	8	1	0	0	0	0	1	0	0	0	8125	893	31	2	1138	2	KDM2B	12	121880300	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	21713441	121880300	11971595	56	557											
PAN3	255967	broad.mit.edu	37	chr13	28841518	28841518	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaccctaatgctgatgcctActtcaccaagagaaagtggg	10	10	1	3			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr13:28841518A>C	uc001urz.2	+	11	1342	c.1334A>C	c.(1333-1335)TAC>TCC	p.Y445S	PAN3_uc010tdo.1_Missense_Mutation_p.Y591S|PAN3_uc001ury.2_Missense_Mutation_p.Y279S|PAN3_uc001urx.2_Missense_Mutation_p.Y391S	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	591	Protein kinase.|Interaction with PAN2.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		GCTGATGCCTACTTCACCAAG	0.363													C	28841518	C	C	28841518	3	2	8	1	0	0	0	0	1	0	0	0	11415	391	14	5	1818	5	PAN3	13	28841518	Missense_Mutation	SNP	A	TCGA-02-2486-01A-01D-1494-08		28841518	86328360	57	558											
RXFP2	122042	broad.mit.edu	37	chr13	32360537	32360537	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagggatctgtctagcaataCgataacggaactatcacctc	8	11	3	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr13:32360537C>T	uc001utt.2	+	12	1018	c.947C>T	c.(946-948)ACG>ATG	p.T316M	RXFP2_uc010aba.2_Missense_Mutation_p.T275M	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	316	Extracellular (Potential).|LRR 8.					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TCTAGCAATACGATAACGGAA	0.358													T	32360537	T	T	32360537	3	4	8	1	0	0	0	0	1	0	0	0	13760	536	19	1	993	1	RXFP2	13	32360537	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	3519019	32360537	82809341	58	559											
SLCO3A1	28232	broad.mit.edu	37	chr15	92663774	92663774	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccgcctgcatggagattgcAgtggtggctggcttcgctgc	16	11	0	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr15:92663774A>C	uc002bqx.2	+	5	1290	c.1089A>C	c.(1087-1089)GCA>GCC	p.A363A	SLCO3A1_uc002bqy.2_Silent_p.A363A|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Silent_p.A305A	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	363	Helical; Name=7; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TGGAGATTGCAGTGGTGGCTG	0.567													C	92663774	C	C	92663774	2	2	8	1	0	0	0	0	0	0	0	1	14728	175	7	5		5	SLCO3A1	15	92663774	Silent	SNP	A	TCGA-02-2486-01A-01D-1494-08		92663774	9867618	59	560											
LASS3	204219	broad.mit.edu	37	chr15	101013181	101013181	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatcacgagggtcccactgCgaatataattagcacaccaa	7	12	2	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr15:101013181C>T	uc002bvz.2	-	10	1188	c.686G>A	c.(685-687)CGC>CAC	p.R229H	LASS3_uc002bwa.2_Missense_Mutation_p.R240H|LASS3_uc002bwb.2_Missense_Mutation_p.R229H	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	229	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			GGTCCCACTGCGAATATAATT	0.433													T	101013181	T	T	101013181	3	4	8	1	0	0	0	0	1	0	0	0	8640	768	27	1	481	1	LASS3	15	101013181	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08	8349407	101013181	1518211	60	561											
PDIA2	64714	broad.mit.edu	37	chr16	334899	334899	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgcaggacgaggacgtgGccaccttcttggccttggcc	13	14	1	0	rs141542731	by1000genomes	TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr16:334899G>A	uc002cgn.1	+	9	1670	c.562G>A	c.(562-564)GCC>ACC	p.A188T	PDIA2_uc010bqt.1_Missense_Mutation_p.A33T|PDIA2_uc002cgo.1_Missense_Mutation_p.A188T	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	188					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CGAGGACGTGGCCACCTTCTT	0.672													A	334899	A	A	334899	3	1	8	1	0	0	0	0	1	0	0	0	11668	1203	42	3	576	3	PDIA2	16	334899	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08		334899	90019854	61	562											
MYH13	8735	broad.mit.edu	37	chr17	10212612	10212612	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcctgctctgacagcctgCgggtccgctccgtctgttcc	11	17	2	1	rs142532419	by1000genomes	TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr17:10212612C>T	uc002gmk.1	-	35	5198	c.5108G>A	c.(5107-5109)CGC>CAC	p.R1703H		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1703	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGACAGCCTGCGGGTCCGCTC	0.667													T	10212612	T	T	10212612	3	4	8	1	0	0	0	0	1	0	0	0	10032	768	27	1	736	1	MYH13	17	10212612	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		10212612	70982598	62	563											
STAT5A	6776	broad.mit.edu	37	chr17	40458321	40458321	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctgtgtgaggcgctcaaCatgaaattcaaggccgaagt	12	9	2	2			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr17:40458321C>T	uc002hzj.1	+	14	2178	c.1536C>T	c.(1534-1536)AAC>AAT	p.N512N	STAT5A_uc010cya.1_Silent_p.N512N|STAT5A_uc010cyb.1_Silent_p.N481N|STAT5A_uc010cyc.1_Silent_p.N482N|STAT5A_uc010cyd.1_5'UTR|STAT5A_uc010cye.1_5'UTR	NM_003152	NP_003143	P42229	STA5A_HUMAN	signal transducer and activator of transcription	512					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		AGGCGCTCAACATGAAATTCA	0.572													T	40458321	T	T	40458321	2	4	8	1	0	0	0	0	0	0	0	1	15267	477	17	3		3	STAT5A	17	40458321	Silent	SNP	C	TCGA-02-2486-01A-01D-1494-08	30245709	40458321	40736889	63	564											
MPP3	4356	broad.mit.edu	37	chr17	41888484	41888484	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccatcaagcaacgtacttgtTgtgatgtaagtcggcctcaa	9	10	2	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr17:41888484T>G	uc002iei.3	-	17	1511	c.1345A>C	c.(1345-1347)AAC>CAC	p.N449H	MPP3_uc002ieh.2_Missense_Mutation_p.N474H|MPP3_uc002iej.2_RNA	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	449	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		ACGTACTTGTTGTGATGTAAG	0.483													G	41888484	G	G	41888484	3	3	8	1	0	0	0	0	1	0	0	0	9735	1812	63	5	428	5	MPP3	17	41888484	Missense_Mutation	SNP	T	TCGA-02-2486-01A-01D-1494-08	1430163	41888484	39306726	64	565											
ASXL3	80816	broad.mit.edu	37	chr18	31320334	31320334	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagatgatcagtcaacccGgaacatatcatctagcagcc	8	11	4	3			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr18:31320334G>A	uc010dmg.1	+	11	3021	c.2966G>A	c.(2965-2967)CGG>CAG	p.R989Q	ASXL3_uc002kxq.2_Missense_Mutation_p.R696Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	989					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CAGTCAACCCGGAACATATCA	0.433													A	31320334	A	A	31320334	3	1	8	1	0	0	0	0	1	0	0	0	1068	1116	39	2	3008	2	ASXL3	18	31320334	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08		31320334	46756914	65	566											
ZNF516	9658	broad.mit.edu	37	chr18	74154420	74154420	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agcctgcacttgaacggcttGtgcgcctggtgcacgtgcag	14	12	0	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr18:74154420G>T	uc010dqx.1	-	2	826	c.591C>A	c.(589-591)CAC>CAA	p.H197Q	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	197	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		TGAACGGCTTGTGCGCCTGGT	0.667													T	74154420	T	T	74154420	3	4	8	1	0	0	0	0	1	0	0	0	17957	1368	48	5	2921	5	ZNF516	18	74154420	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08	42834086	74154420	3922828	66	567											
CCDC105	126402	broad.mit.edu	37	chr19	15132195	15132195	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgctaaacgaagccaagcGgttgttggtcgagtccaagg	15	9	0	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr19:15132195G>A	uc002nae.2	+	4	1004	c.905G>A	c.(904-906)CGG>CAG	p.R302Q		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	302	Potential.				microtubule cytoskeleton organization	microtubule				ovary(1)	1						GAAGCCAAGCGGTTGTTGGTC	0.597													A	15132195	A	A	15132195	3	1	8	1	0	0	0	0	1	0	0	0	2740	1116	39	2	919	2	CCDC105	19	15132195	Missense_Mutation	SNP	G	TCGA-02-2486-01A-01D-1494-08		15132195	43996788	67	568											
TMEM161A	54929	broad.mit.edu	37	chr19	19232455	19232455	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cactgccagtcccacgcggaTagccagcttggccacaggaa	11	15	0	0			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr19:19232455T>C	uc002nlg.2	-	8	709	c.679A>G	c.(679-681)ATC>GTC	p.I227V	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Missense_Mutation_p.I202V|TMEM161A_uc002nli.2_Missense_Mutation_p.I124V|TMEM161A_uc002nlj.2_Missense_Mutation_p.I102V	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	227	Helical; (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			CCCACGCGGATAGCCAGCTTG	0.677													C	19232455	C	C	19232455	3	2	8	1	0	0	0	0	1	0	0	0	16073	1406	49	4	780	4	TMEM161A	19	19232455	Missense_Mutation	SNP	T	TCGA-02-2486-01A-01D-1494-08	4100260	19232455	39896528	68	569											
NUP62	23636	broad.mit.edu	37	chr19	50411934	50411934	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcttcaccttctccacctcGcggtgcaggctggtgatctt	10	14	3	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr19:50411934G>A	uc002pqx.2	-	2	1235	c.1131C>T	c.(1129-1131)CGC>CGT	p.R377R	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Silent_p.R377R|NUP62_uc002pqz.2_Silent_p.R377R|NUP62_uc002pra.2_Silent_p.R377R|NUP62_uc002prb.2_Silent_p.R377R|NUP62_uc002prc.2_Silent_p.R301R	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	377	Potential.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TCTCCACCTCGCGGTGCAGGC	0.612													A	50411934	A	A	50411934	2	1	8	1	0	0	0	0	0	0	0	1	10768	1074	38	1		1	NUP62	19	50411934	Silent	SNP	G	TCGA-02-2486-01A-01D-1494-08	31179479	50411934	8717049	69	570											
ISM1	140862	broad.mit.edu	37	chr20	13279712	13279712	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgaggtggcctacagcaCggccgacatcttcgaccgca	11	15	1	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chr20:13279712C>T	uc010gce.1	+	6	1007	c.1001C>T	c.(1000-1002)ACG>ATG	p.T334M	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	334	AMOP.					extracellular region					0						GCCTACAGCACGGCCGACATC	0.582													T	13279712	T	T	13279712	3	4	8	1	0	0	0	0	1	0	0	0	7860	536	19	1	1023	1	ISM1	20	13279712	Missense_Mutation	SNP	C	TCGA-02-2486-01A-01D-1494-08		13279712	49745808	70	571											
GRPR	2925	broad.mit.edu	37	chrX	16142187	16142187	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacgatgactggtcccacccGgggatcctctatgtcatccc	9	15	2	1			TCGA-02-2486-01A-01D-1494-08	TCGA-02-2486-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3331813c-f538-4833-b5eb-a214b7d52334	334697ef-d664-4d24-9ddb-c4d7448fd00d	g.chrX:16142187G>A	uc004cxj.2	+	1	764	c.111G>A	c.(109-111)CCG>CCA	p.P37P		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	37	Extracellular (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					GGTCCCACCCGGGGATCCTCT	0.488											OREG0019682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	16142187	A	A	16142187	2	1	8	1	0	0	0	0	0	0	0	1	6808	1103	39	2		2	GRPR	23	16142187	Silent	SNP	G	TCGA-02-2486-01A-01D-1494-08		16142187	139128373	71	572											
TTC22	55001	broad.mit.edu	37	chr1	55266546	55266546	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccaggcattgaggttgccCgggtgctcgtgggccacctc	15	14	0	1	rs35670637		TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr1:55266546C>T	uc009vzt.1	-	1	396	c.291G>A	c.(289-291)CCG>CCA	p.P97P	TTC22_uc001cxz.3_Silent_p.P97P	NM_001114108	NP_001107580	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22 isoform 1	97	TPR 1.						binding				0						TGAGGTTGCCCGGGTGCTCGT	0.687													T	55266546	T	T	55266546	2	4	9	1	0	0	0	0	0	0	0	1	16686	639	23	2		2	TTC22	1	55266546	Silent	SNP	C	TCGA-06-0119-01A-08D-1490-08		55266546	193984075	1	573											
SPAG17	200162	broad.mit.edu	37	chr1	118624163	118624163	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aatctgacccacacatcatcCcagaaggtttcagtttccct	5	14	3	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr1:118624163C>G	uc001ehk.2	-	14	1933	c.1865G>C	c.(1864-1866)GGG>GCG	p.G622A		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	622						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ACACATCATCCCAGAAGGTTT	0.428													G	118624163	G	G	118624163	3	3	9	1	0	0	0	0	1	0	0	0	14979	623	22	5	4946	5	SPAG17	1	118624163	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	63357617	118624163	130626458	2	574											
ADAM30	11085	broad.mit.edu	37	chr1	120438344	120438344	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	atcaaagagtaggatcaattCcaagtactttgggtgtttat	9	5	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr1:120438344C>G	uc001eij.2	-	1	770	c.616G>C	c.(616-618)GAA>CAA	p.E206Q		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	206	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AGGATCAATTCCAAGTACTTT	0.403													G	120438344	G	G	120438344	3	3	9	1	0	0	0	0	1	0	0	0	248	864	30	5	1760	5	ADAM30	1	120438344	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	1814181	120438344	128812277	3	575											
GPR52	9293	broad.mit.edu	37	chr1	174417320	174417320	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattgtgaatgtgtccgagcGtcactcctgcccacttggat	10	12	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr1:174417320G>A	uc001gka.1	+	1	109	c.71G>A	c.(70-72)CGT>CAT	p.R24H	RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjx.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_Intron	NM_005684	NP_005675	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	24	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1						GTGTCCGAGCGTCACTCCTGC	0.483													A	174417320	A	A	174417320	3	1	9	1	0	0	0	0	1	0	0	0	6698	1145	40	1	73	1	GPR52	1	174417320	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	53978976	174417320	74833301	4	576											
HMCN1	83872	broad.mit.edu	37	chr1	186056355	186056355	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctatttacctacaggtggtcGaactctacagattattcggg	9	9	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr1:186056355G>A	uc001grq.1	+	59	9282	c.9053G>A	c.(9052-9054)CGA>CAA	p.R3018Q		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3018	Ig-like C2-type 28.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACAGGTGGTCGAACTCTACAG	0.383													A	186056355	A	A	186056355	3	1	9	1	0	0	0	0	1	0	0	0	7220	1058	37	2	9287	2	HMCN1	1	186056355	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	11639035	186056355	63194266	5	577											
COG2	22796	broad.mit.edu	37	chr1	230807312	230807312	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccaatggccttcaggtcatGtataataaactcctggagtt	8	10	2	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr1:230807312G>C	uc001htw.2	+	8	976	c.825G>C	c.(823-825)ATG>ATC	p.M275I	COG2_uc001htx.2_Missense_Mutation_p.M275I|COG2_uc010pwc.1_Missense_Mutation_p.M148I	NM_007357	NP_031383	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2 isoform	275					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TTCAGGTCATGTATAATAAAC	0.393													C	230807312	C	C	230807312	3	2	9	1	0	0	0	0	1	0	0	0	3658	1377	48	5	855	5	COG2	1	230807312	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	44750957	230807312	18443309	6	578											
PCNXL2	80003	broad.mit.edu	37	chr1	233394169	233394169	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgatgaagaactgtgatccTtgatggcatttcccccctcc	9	12	0	5			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr1:233394169T>C	uc001hvl.2	-	5	1674	c.1439A>G	c.(1438-1440)AAG>AGG	p.K480R	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	480						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				ACTGTGATCCTTGATGGCATT	0.542													C	233394169	C	C	233394169	3	2	9	1	0	0	0	0	1	0	0	0	11592	1609	56	4	5094	4	PCNXL2	1	233394169	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08	2586857	233394169	15856452	7	579											
C2orf16	84226	broad.mit.edu	37	chr2	27801373	27801373	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acatcttcaagaactgatagTacctgcagaattaactccaa	5	10	2	3			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr2:27801373T>C	uc002rkz.3	+	1	1985	c.1934T>C	c.(1933-1935)GTA>GCA	p.V645A		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	645										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					GAACTGATAGTACCTGCAGAA	0.403													C	27801373	C	C	27801373	3	2	9	1	0	0	0	0	1	0	0	0	2157	1638	57	4	1936	4	C2orf16	2	27801373	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08		27801373	215398000	8	580											
SLC9A4	389015	broad.mit.edu	37	chr2	103149074	103149074	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctctttggttgaggttcggtCgaggtggacagctgaccatg	15	8	1	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr2:103149074C>T	uc002tbz.3	+	12	2781	c.2324C>T	c.(2323-2325)TCG>TTG	p.S775L		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	775	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GAGGTTCGGTCGAGGTGGACA	0.517													T	103149074	T	T	103149074	3	4	9	1	0	0	0	0	1	0	0	0	14716	893	31	2	2370	2	SLC9A4	2	103149074	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	75347701	103149074	140050299	9	581											
LRP2	4036	broad.mit.edu	37	chr2	169985569	169985569	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggtagtttgtttagattttCgtttgaagagattccatttt	9	3	0	3			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr2:169985569C>T	uc002ues.2	-	78	13967	c.13754G>A	c.(13753-13755)CGA>CAA	p.R4585Q		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4585	Cytoplasmic (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.R4585*(1)		ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTTAGATTTTCGTTTGAAGAG	0.313													T	169985569	T	T	169985569	3	4	9	1	0	0	0	0	1	0	0	0	8956	884	31	2	221	2	LRP2	2	169985569	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	66836495	169985569	73213804	10	582											
TTN	7273	broad.mit.edu	37	chr2	179463526	179463526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcagacttgctggacccaCgccagcagcattgattgcat	11	12	0	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr2:179463526C>T	uc010zfg.1	-	240	49431	c.49207G>A	c.(49207-49209)GTG>ATG	p.V16403M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V10098M|TTN_uc010zfi.1_Missense_Mutation_p.V10031M|TTN_uc010zfj.1_Missense_Mutation_p.V9906M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17330							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGGACCCACGCCAGCAGCA	0.428													T	179463526	T	T	179463526	3	4	9	1	0	0	0	0	1	0	0	0	16732	536	19	1	51070	1	TTN	2	179463526	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	9477957	179463526	63735847	11	583											
PID1	55022	broad.mit.edu	37	chr2	229890703	229890703	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccggatttccaggagggcaTtggccggaaagacatcctct	13	11	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr2:229890703T>C	uc002vpr.3	-	3	436	c.398A>G	c.(397-399)AAT>AGT	p.N133S	PID1_uc002vps.3_Missense_Mutation_p.N131S|PID1_uc002vpt.3_Missense_Mutation_p.N100S|PID1_uc002vpu.3_Missense_Mutation_p.N51S	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	133	PID.					cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		CAGGAGGGCATTGGCCGGAAA	0.557													C	229890703	C	C	229890703	3	2	9	1	0	0	0	0	1	0	0	0	11882	1493	52	4	358	4	PID1	2	229890703	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08	50427177	229890703	13308670	12	584											
COL6A3	1293	broad.mit.edu	37	chr2	238285526	238285526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gataaacgctggagacagcaCgatctgctctaactcagcag	10	11	3	1	rs140437593	byFrequency	TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr2:238285526C>T	uc002vwl.2	-	7	3244	c.2959G>A	c.(2959-2961)GTG>ATG	p.V987M	COL6A3_uc002vwo.2_Missense_Mutation_p.V781M|COL6A3_uc010znj.1_Missense_Mutation_p.V380M|COL6A3_uc002vwq.2_Missense_Mutation_p.V781M|COL6A3_uc002vwr.2_Missense_Mutation_p.V580M|COL6A3_uc010znk.1_Missense_Mutation_p.V787M	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	987	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGAGACAGCACGATCTGCTCT	0.512													T	238285526	T	T	238285526	3	4	9	1	0	0	0	0	1	0	0	0	3701	536	19	1	6773	1	COL6A3	2	238285526	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	8394823	238285526	4913847	13	585											
CACNA1D	776	broad.mit.edu	37	chr3	53769408	53769408	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttccctgcaggatccgcGtaggctgccacaagctcatc	9	15	1	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr3:53769408G>A	uc003dgv.3	+	20	2792	c.2629G>A	c.(2629-2631)GTA>ATA	p.V877I	CACNA1D_uc003dgu.3_Missense_Mutation_p.V897I|CACNA1D_uc003dgy.3_Missense_Mutation_p.V877I|CACNA1D_uc003dgw.3_Missense_Mutation_p.V544I|CACNA1D_uc003dgx.1_Missense_Mutation_p.V25I	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	877	Cytoplasmic (Potential).|III.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CAGGATCCGCGTAGGCTGCCA	0.587													A	53769408	A	A	53769408	3	1	9	1	0	0	0	0	1	0	0	0	2541	1145	40	1	2879	1	CACNA1D	3	53769408	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08		53769408	144253022	14	586											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178936091	A	A	178936091	3	1	9	1	0	0	0	0	1	0	0	0	11913	1291	45	3	1667	3	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	125166683	178936091	19086339	15	587											
CSN2	1447	broad.mit.edu	37	chr4	70823297	70823297	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatttgagggtcaaaaaaggGtatcgttggagatttaagga	14	2	1	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr4:70823297G>T	uc003hes.3	-	5	383	c.370C>A	c.(370-372)CCC>ACC	p.P124T	CSN2_uc003het.3_Missense_Mutation_p.P123T	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	124					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						TCAAAAAAGGGTATCGTTGGA	0.483													T	70823297	T	T	70823297	3	4	9	1	0	0	0	0	1	0	0	0	3948	1261	44	5	318	5	CSN2	4	70823297	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08		70823297	120330979	16	588											
KIAA1109	84162	broad.mit.edu	37	chr4	123200986	123200986	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctctacagtgcccaaagagGgctgaagacaaacaatgctg	10	11	1	3			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr4:123200986G>T	uc003ieh.2	+	49	8693	c.8648G>T	c.(8647-8649)GGG>GTG	p.G2883V	KIAA1109_uc003iel.1_Missense_Mutation_p.G818V	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2883					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GCCCAAAGAGGGCTGAAGACA	0.433													T	123200986	T	T	123200986	3	4	9	1	0	0	0	0	1	0	0	0	8208	1232	43	5	8842	5	KIAA1109	4	123200986	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	52377689	123200986	67953290	17	589											
ADAMTS16	170690	broad.mit.edu	37	chr5	5262847	5262847	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttctgcaatcccaagacaCgacctgtcacggggctggtg	11	14	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr5:5262847C>T	uc003jdl.2	+	18	2878	c.2740C>T	c.(2740-2742)CGA>TGA	p.R914*	ADAMTS16_uc003jdk.1_Nonsense_Mutation_p.R914*	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	914	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TCCCAAGACACGACCTGTCAC	0.512													T	5262847	T	T	5262847	4	4	9	1	0	0	0	0	0	1	0	0	261	528	19	1	2810	1	ADAMTS16	5	5262847	Nonsense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08		5262847	175652413	18	590											
PCDHB15	56121	broad.mit.edu	37	chr5	140627258	140627258	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcgctcttcctcttctcGgtgttcctgttcgtggcagt	9	13	4	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr5:140627258G>A	uc003lje.2	+	1	2112	c.2112G>A	c.(2110-2112)TCG>TCA	p.S704S		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	704	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTCTTCTCGGTGTTCCTGT	0.682													A	140627258	A	A	140627258	2	1	9	1	0	0	0	0	0	0	0	1	11540	1103	39	2		2	PCDHB15	5	140627258	Silent	SNP	G	TCGA-06-0119-01A-08D-1490-08	135364411	140627258	40288002	19	591											
KCTD16	57528	broad.mit.edu	37	chr5	143586570	143586570	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caggcaggtggtcctgcctgAtcactttccagaaaaaggaa	11	10	1	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr5:143586570A>T	uc003lnm.1	+	3	922	c.293A>T	c.(292-294)GAT>GTT	p.D98V	KCTD16_uc003lnn.1_Missense_Mutation_p.D98V	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	98	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			GTCCTGCCTGATCACTTTCCA	0.478													T	143586570	T	T	143586570	3	4	9	1	0	0	0	0	1	0	0	0	8103	333	12	5	295	5	KCTD16	5	143586570	Missense_Mutation	SNP	A	TCGA-06-0119-01A-08D-1490-08	2959312	143586570	37328690	20	592											
OR12D2	26529	broad.mit.edu	37	chr6	29364556	29364556	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actgcagccttttctcttcgTggttttcctcaccatctact	5	14	3	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr6:29364556T>C	uc003nmf.3	+	1	141	c.80T>C	c.(79-81)GTG>GCG	p.V27A		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTTCTCTTCGTGGTTTTCCTC	0.438													C	29364556	C	C	29364556	3	2	9	1	0	0	0	0	1	0	0	0	10931	1696	59	4	82	4	OR12D2	6	29364556	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08		29364556	141750511	21	593											
UBD	10537	broad.mit.edu	37	chr6	29523710	29523710	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taagttgccctttctgatgcCgtaatctgccatcatcttcc	6	13	4	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr6:29523710C>T	uc003nmo.2	-	2	669	c.445G>A	c.(445-447)GGC>AGC	p.G149S	GABBR1_uc003nmp.3_3'UTR	NM_006398	NP_006389	O15205	UBD_HUMAN	ubiquitin D	149	Ubiquitin 2.				aggresome assembly|myeloid dendritic cell differentiation|negative regulation of mitotic prometaphase|positive regulation of apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	aggresome|cytoplasm|nucleus	proteasome binding				0						TTTCTGATGCCGTAATCTGCC	0.473													T	29523710	T	T	29523710	3	4	9	1	0	0	0	0	1	0	0	0	16840	652	23	2	56	2	UBD	6	29523710	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	159154	29523710	141591357	22	594											
COL12A1	1303	broad.mit.edu	37	chr6	75840567	75840567	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaaaggatttctgcctcaCgcgttcggccctgggcaggg	15	11	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr6:75840567C>T	uc003phs.2	-	36	6233	c.6067_splice	c.e36+1	p.L2023_splice	COL12A1_uc003pht.2_Splice_Site_p.L859_splice	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform						cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TTCTGCCTCACGCGTTCGGCC	0.562													T	75840567	T	T	75840567	5	4	9	1	0	0	0	0	0	0	1	0	3669	550	19	1	3247	1	COL12A1	6	75840567	Splice_Site	SNP	C	TCGA-06-0119-01A-08D-1490-08	46316857	75840567	95274500	23	595											
THEMIS	387357	broad.mit.edu	37	chr6	128134889	128134889	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttttcccaggctgtaaaatGctttggggcaggtggtttcc	13	8	0	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr6:128134889G>A	uc003qbi.2	-	5	1216	c.897C>T	c.(895-897)AGC>AGT	p.S299S	THEMIS_uc010kfa.2_Silent_p.S202S|THEMIS_uc011ebt.1_Silent_p.S299S|THEMIS_uc010kfb.2_Silent_p.S264S	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	299	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						GCTGTAAAATGCTTTGGGGCA	0.393													A	128134889	A	A	128134889	2	1	9	1	0	0	0	0	0	0	0	1	15857	1310	46	3		3	THEMIS	6	128134889	Silent	SNP	G	TCGA-06-0119-01A-08D-1490-08	52294322	128134889	42980178	24	596											
GPR126	57211	broad.mit.edu	37	chr6	142736934	142736934	+	Frame_Shift_Del	DEL	A	-	-													tccttttttcattttttaggAaattgcgaagggattatccc							TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr6:142736934delA	uc010khc.2	+	20	3082	c.2671delA	c.(2671-2673)AAAfs	p.K891fs	GPR126_uc010khd.2_Frame_Shift_Del_p.K863fs|GPR126_uc010khe.2_Frame_Shift_Del_p.K891fs|GPR126_uc010khf.2_Frame_Shift_Del_p.K863fs	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	891	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		ATTTTTTAGGAAATTGCGAAG	0.398													-	142736934	-	-	142736934	7	5	9	1	0	1	0	1	0	0	0	0	6640	260	9	0	2749	0	GPR126	6	142736934	Frame_Shift_Del	DEL	A	TCGA-06-0119-01A-08D-1490-08	14602045	142736934	28378133	25	597											
SEMA3E	9723	broad.mit.edu	37	chr7	83016344	83016344	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgagctgcatttccatgtcGaacatcttgtctccggaaac	8	12	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr7:83016344G>A	uc003uhy.1	-	15	2156	c.1690C>T	c.(1690-1692)CGA>TGA	p.R564*		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	564					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TTTCCATGTCGAACATCTTGT	0.363													A	83016344	A	A	83016344	4	1	9	1	0	0	0	0	0	1	0	0	14028	1066	37	2	649	2	SEMA3E	7	83016344	Nonsense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08		83016344	76122319	26	598											
COL1A2	1278	broad.mit.edu	37	chr7	94052404	94052404	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggcttcgctggtgagaagGgtccctctggagaggctggt	17	9	1	2	rs72658196		TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr7:94052404G>A	uc003ung.1	+	40	3010	c.2539G>A	c.(2539-2541)GGT>AGT	p.G847S	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	847			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGGTGAGAAGGGTCCCTCTGG	0.502										HNSCC(75;0.22)			A	94052404	A	A	94052404	3	1	9	1	0	0	0	0	1	0	0	0	3678	1232	43	3	2697	3	COL1A2	7	94052404	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	11036060	94052404	65086259	27	599											
TRIM4	89122	broad.mit.edu	37	chr7	99516919	99516919	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cggcgcccagttgcggtgcaGgcagccgcggcagaagttgt	17	12	0	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr7:99516919G>T	uc003usd.2	-	1	236	c.106C>A	c.(106-108)CTG>ATG	p.L36M	TRIM4_uc003use.2_Missense_Mutation_p.L36M|TRIM4_uc011kjc.1_Translation_Start_Site|TRIM4_uc003usf.2_Missense_Mutation_p.L36M	NM_033017	NP_148977	Q9C037	TRIM4_HUMAN	tripartite motif protein TRIM4 isoform alpha	36	RING-type.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			ovary(1)|kidney(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				TTGCGGTGCAGGCAGCCGCGG	0.701													T	99516919	T	T	99516919	3	4	9	1	0	0	0	0	1	0	0	0	16511	991	35	5	1424	5	TRIM4	7	99516919	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	5464515	99516919	59621744	28	600											
OR2A12	346525	broad.mit.edu	37	chr7	143792582	143792582	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtatgtggcaatctgtcacCccttgcaatacaccctcatt	7	13	3	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr7:143792582C>A	uc011kty.1	+	1	382	c.382C>A	c.(382-384)CCC>ACC	p.P128T		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					AATCTGTCACCCCTTGCAATA	0.433													A	143792582	A	A	143792582	3	1	9	1	0	0	0	0	1	0	0	0	10975	623	22	5	384	5	OR2A12	7	143792582	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	44275663	143792582	15346081	29	601											
PTK2B	2185	broad.mit.edu	37	chr8	27301729	27301729	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttctctctccagcccagcCgacctaagtacagaccccct	6	18	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr8:27301729C>T	uc003xfn.1	+	28	2963	c.2155C>T	c.(2155-2157)CGA>TGA	p.R719*	PTK2B_uc003xfo.1_Nonsense_Mutation_p.R719*|PTK2B_uc003xfp.1_Nonsense_Mutation_p.R719*|PTK2B_uc003xfq.1_Nonsense_Mutation_p.R719*|PTK2B_uc003xfr.1_Nonsense_Mutation_p.R465*	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	719	Pro-rich.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CCAGCCCAGCCGACCTAAGTA	0.542													T	27301729	T	T	27301729	4	4	9	1	0	0	0	0	0	1	0	0	12763	644	23	2	2241	2	PTK2B	8	27301729	Nonsense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08		27301729	119062293	30	602											
FAM164A	51101	broad.mit.edu	37	chr8	79590915	79590915	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaaacctctcaaaccgaggGtaactatataaccttttgaa	5	9	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr8:79590915G>A	uc003ybd.2	+	3	312	c.210_splice	c.e3+1	p.R70_splice		NM_016010	NP_057094	Q96GY0	F164A_HUMAN	hypothetical protein LOC51101											ovary(1)	1						CAAACCGAGGGTAACTATATA	0.333													A	79590915	A	A	79590915	5	1	9	1	0	0	0	0	0	0	1	0	5478	1275	44	3	221	3	FAM164A	8	79590915	Splice_Site	SNP	G	TCGA-06-0119-01A-08D-1490-08	52289186	79590915	66773107	31	603											
RAD54B	25788	broad.mit.edu	37	chr8	95403893	95403893	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagttttttaagagctcctaTacatattagatggggactat	8	6	0	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr8:95403893T>A	uc003ygk.2	-	10	1851	c.1753A>T	c.(1753-1755)ATA>TTA	p.I585L	RAD54B_uc010may.1_Missense_Mutation_p.I392L|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			AGAGCTCCTATACATATTAGA	0.408								Direct_reversal_of_damage|Homologous_recombination					A	95403893	A	A	95403893	3	1	9	1	0	0	0	0	1	0	0	0	12992	1406	49	5	1003	5	RAD54B	8	95403893	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08	15812978	95403893	50960129	32	604											
PLEC	5339	broad.mit.edu	37	chr8	144990758	144990758	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccgtgccgcgctgcagggCctcgtccaggggcacgcggc	16	17	0	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr8:144990758C>T	uc003zaf.1	-	32	13812	c.13642G>A	c.(13642-13644)GCC>ACC	p.A4548T	PLEC_uc003zab.1_Missense_Mutation_p.A4411T|PLEC_uc003zac.1_Missense_Mutation_p.A4415T|PLEC_uc003zad.2_Missense_Mutation_p.A4411T|PLEC_uc003zae.1_Missense_Mutation_p.A4379T|PLEC_uc003zag.1_Missense_Mutation_p.A4389T|PLEC_uc003zah.2_Missense_Mutation_p.A4397T|PLEC_uc003zaj.2_Missense_Mutation_p.A4438T	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4548	Plectin 32.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCTGCAGGGCCTCGTCCAGG	0.682													T	144990758	T	T	144990758	3	4	9	1	0	0	0	0	1	0	0	0	12052	739	26	3	416	3	PLEC	8	144990758	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	49586865	144990758	1373264	33	605											
RMI1	80010	broad.mit.edu	37	chr9	86616796	86616796	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctccaagaccaaaagaggaaCcatcaaacctatctatacat	4	12	2	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr9:86616796C>A	uc004anq.3	+	3	1303	c.895C>A	c.(895-897)CCA>ACA	p.P299T	RMI1_uc004anr.3_Missense_Mutation_p.P299T|RMI1_uc004anp.3_Missense_Mutation_p.P299T|RMI1_uc004ans.3_Missense_Mutation_p.P299T	NM_024945	NP_079221	Q9H9A7	RMI1_HUMAN	RMI1, RecQ mediated genome instability 1,	299					DNA replication	nucleus					0						AAAAGAGGAACCATCAAACCT	0.398													A	86616796	A	A	86616796	3	1	9	1	0	0	0	0	1	0	0	0	13395	507	18	5	897	5	RMI1	9	86616796	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08		86616796	54596635	34	606											
LHX3	8022	broad.mit.edu	37	chr9	139092527	139092527	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acttgagacacttgctgtgcCagtggcggtccagagccttg	13	11	0	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr9:139092527C>A	uc004cha.2	-	2	249	c.152G>T	c.(151-153)TGG>TTG	p.W51L	LHX3_uc004cgz.2_Missense_Mutation_p.W56L	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	51	LIM zinc-binding 1.				inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		CTTGCTGTGCCAGTGGCGGTC	0.607													A	139092527	A	A	139092527	3	1	9	1	0	0	0	0	1	0	0	0	8772	595	21	5	1061	5	LHX3	9	139092527	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	52475731	139092527	2120904	35	607											
OR56A4	120793	broad.mit.edu	37	chr11	6023660	6023660	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtcatcacaagagagtttgGacacagacaggttactgcag	11	8	2	2	rs116778909	by1000genomes	TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr11:6023660G>A	uc010qzv.1	-	1	719	c.719C>T	c.(718-720)TCC>TTC	p.S240F		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGAGTTTGGACACAGACAG	0.443													A	6023660	A	A	6023660	3	1	9	1	0	0	0	0	1	0	0	0	11135	1174	41	3	380	3	OR56A4	11	6023660	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08		6023660	128982856	36	608											
NAT10	55226	broad.mit.edu	37	chr11	34129864	34129864	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctctttgttgtagttggggAtcgaggaaaagatcaggtat	13	4	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr11:34129864A>C	uc001mvk.2	+	2	336	c.92A>C	c.(91-93)GAT>GCT	p.D31A	NAT10_uc010ren.1_Intron	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	31						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				GTAGTTGGGGATCGAGGAAAA	0.423													C	34129864	C	C	34129864	3	2	9	1	0	0	0	0	1	0	0	0	10174	333	12	5	94	5	NAT10	11	34129864	Missense_Mutation	SNP	A	TCGA-06-0119-01A-08D-1490-08	28106204	34129864	100876652	37	609											
SPRYD5	84767	broad.mit.edu	37	chr11	55653246	55653246	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagagcctgctctgtttgccGtgctccaactctcaggagca	10	13	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr11:55653246G>A	uc010rip.1	+	2	434	c.342G>A	c.(340-342)CCG>CCA	p.P114P	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	114	B box-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TCTGTTTGCCGTGCTCCAACT	0.507													A	55653246	A	A	55653246	2	1	9	1	0	0	0	0	0	0	0	1	15110	1132	40	1		1	SPRYD5	11	55653246	Silent	SNP	G	TCGA-06-0119-01A-08D-1490-08	21523382	55653246	79353270	38	610											
OR8K3	219473	broad.mit.edu	37	chr11	56086106	56086106	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctttctttcttgtgttcatTggtagtgaactttttattct	7	6	4	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr11:56086106T>G	uc010rjf.1	+	1	324	c.324T>G	c.(322-324)ATT>ATG	p.I108M		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TTGTGTTCATTGGTAGTGAAC	0.378													G	56086106	G	G	56086106	3	3	9	1	0	0	0	0	1	0	0	0	11244	1800	63	5	326	5	OR8K3	11	56086106	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08	432860	56086106	78920410	39	611											
TPCN2	219931	broad.mit.edu	37	chr11	68854047	68854047	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcgtctgtcatctgggtcaAcctgtttctggccctgattc	10	12	5	1	rs150476703		TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr11:68854047A>G	uc001oos.2	+	23	2176	c.2060A>G	c.(2059-2061)AAC>AGC	p.N687S	TPCN2_uc010rqg.1_Intron|TPCN2_uc001oot.2_RNA	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	687	Helical; Name=S6 of repeat II; (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ATCTGGGTCAACCTGTTTCTG	0.532													G	68854047	G	G	68854047	3	3	9	1	0	0	0	0	1	0	0	0	16393	43	2	4	2150	4	TPCN2	11	68854047	Missense_Mutation	SNP	A	TCGA-06-0119-01A-08D-1490-08	12767941	68854047	66152469	40	612											
SLCO1A2	6579	broad.mit.edu	37	chr12	21457447	21457447	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggagtttcacccattccaCgtacaatattgcctactagg	8	11	1	0	rs148616059	byFrequency	TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr12:21457447C>T	uc001rer.2	-	5	754	c.503G>A	c.(502-504)CGT>CAT	p.R168H	SLCO1A2_uc001res.2_Missense_Mutation_p.R168H|SLCO1A2_uc010siq.1_Missense_Mutation_p.R36H|SLCO1A2_uc010sio.1_Missense_Mutation_p.R36H|SLCO1A2_uc010sip.1_Missense_Mutation_p.R36H|SLCO1A2_uc001ret.2_Missense_Mutation_p.R166H|SLCO1A2_uc001reu.2_Missense_Mutation_p.R148H	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	168	Helical; Name=4; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ACCCATTCCACGTACAATATT	0.348													T	21457447	T	T	21457447	3	4	9	1	0	0	0	0	1	0	0	0	14722	536	19	1	1549	1	SLCO1A2	12	21457447	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08		21457447	112394448	41	613											
DDX11	1663	broad.mit.edu	37	chr12	31255360	31255360	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcgtctgggtttctcctacaGgcctgtggccaggagagagg	16	10	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr12:31255360G>T	uc001rjt.1	+	23	2523	c.2272_splice	c.e23-1	p.A758_splice	DDX11_uc001rjr.1_Splice_Site_p.A758_splice|DDX11_uc001rjs.1_Splice_Site_p.A708_splice|DDX11_uc001rju.1_Splice_Site_p.A430_splice|DDX11_uc001rjv.1_Splice_Site_p.A758_splice|DDX11_uc001rjw.1_Splice_Site_p.A732_splice|DDX11_uc009zjn.1_Splice_Site|DDX11_uc009zjo.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11						G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					TTCTCCTACAGGCCTGTGGCC	0.577										Multiple Myeloma(12;0.14)			T	31255360	T	T	31255360	5	4	9	1	0	0	0	0	0	0	1	0	4343	1014	35	5	2357	5	DDX11	12	31255360	Splice_Site	SNP	G	TCGA-06-0119-01A-08D-1490-08	9797913	31255360	102596535	42	614											
NUP107	57122	broad.mit.edu	37	chr12	69124921	69124921	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agagaaacatacaaatcttaTagcattttatacctgtcatt	4	7	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr12:69124921T>C	uc001suf.2	+	21	1881	c.1766T>C	c.(1765-1767)ATA>ACA	p.I589T	NUP107_uc001sug.2_Intron|NUP107_uc010stj.1_Missense_Mutation_p.I560T	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	589					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			ACAAATCTTATAGCATTTTAT	0.303													C	69124921	C	C	69124921	3	2	9	1	0	0	0	0	1	0	0	0	10753	1406	49	4	1848	4	NUP107	12	69124921	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08	37869561	69124921	64726974	43	615											
TRHDE	29953	broad.mit.edu	37	chr12	73014949	73014949	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgggtggccgaaaaataattTtaatggatctcttgttcaag	10	5	2	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr12:73014949T>A	uc001sxa.2	+	14	2426	c.2396T>A	c.(2395-2397)TTT>TAT	p.F799Y		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	799	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AAAAATAATTTTAATGGATCT	0.323													A	73014949	A	A	73014949	3	1	9	1	0	0	0	0	1	0	0	0	16476	1841	64	5	2450	5	TRHDE	12	73014949	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08	3890028	73014949	60836946	44	616											
GPR109B	8843	broad.mit.edu	37	chr12	123200283	123200283	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcctctggttttgttgggGtcccctgtgagctcgacgct	14	12	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr12:123200283G>A	uc001ucy.3	-	1	1157	c.1002C>T	c.(1000-1002)GAC>GAT	p.D334D	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	334	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	TTTTGTTGGGGTCCCCTGTGA	0.542													A	123200283	A	A	123200283	2	1	9	1	0	0	0	0	0	0	0	1	6626	1252	44	3		3	GPR109B	12	123200283	Silent	SNP	G	TCGA-06-0119-01A-08D-1490-08	50185334	123200283	10651612	45	617											
FLT3	2322	broad.mit.edu	37	chr13	28592705	28592705	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgacaagcacgttcctggCggccaggtctctgtgaacac	13	12	1	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr13:28592705C>T	uc001urw.2	-	20	2522	c.2440G>A	c.(2440-2442)GCC>ACC	p.A814T	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Intron	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	814	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACGTTCCTGGCGGCCAGGTCT	0.453			Mis|O		AML|ALL								T	28592705	T	T	28592705	3	4	9	1	0	0	0	0	1	0	0	0	5942	768	27	1	561	1	FLT3	13	28592705	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08		28592705	86577173	46	618											
YLPM1	56252	broad.mit.edu	37	chr14	75264755	75264755	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaagtctcggaagggcccGtagagccctctaattgggac	14	10	2	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr14:75264755G>A	uc001xqj.3	+	5	2879	c.2755G>A	c.(2755-2757)GTA>ATA	p.V919I	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	724					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GGAAGGGCCCGTAGAGCCCTC	0.483													A	75264755	A	A	75264755	3	1	9	1	0	0	0	0	1	0	0	0	17483	1145	40	1	2773	1	YLPM1	14	75264755	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08		75264755	32084785	47	619											
SETD3	84193	broad.mit.edu	37	chr14	99866491	99866491	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggctctatcttcaagaaatGtccaaagtttgacctcgttg	8	9	3	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr14:99866491G>A	uc001ygc.2	-	12	1453	c.1283C>T	c.(1282-1284)ACA>ATA	p.T428I		NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	428					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				ttcaagaaatgtccaaagttt	0.303													A	99866491	A	A	99866491	3	1	9	1	0	0	0	0	1	0	0	0	14132	1377	48	3	509	3	SETD3	14	99866491	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	24601736	99866491	7483049	48	620											
HDC	3067	broad.mit.edu	37	chr15	50534686	50534686	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cactcactggcacactgttgCaactgagggagcgcaccgtc	11	14	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr15:50534686C>A	uc001zxz.2	-	12	1866	c.1760G>T	c.(1759-1761)TGC>TTC	p.C587F	HDC_uc001zxy.2_Missense_Mutation_p.C330F|HDC_uc010uff.1_Missense_Mutation_p.C554F	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	587					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	CACACTGTTGCAACTGAGGGA	0.542													A	50534686	A	A	50534686	3	1	9	1	0	0	0	0	1	0	0	0	7015	710	25	5	232	5	HDC	15	50534686	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08		50534686	51996706	49	621											
C17orf68	80169	broad.mit.edu	37	chr17	8136310	8136310	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggtcccgaagttgcagaCaacctttatgagatgaagcc	10	9	0	3			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:8136310C>T	uc002gkq.3	-	11	1918	c.1859G>A	c.(1858-1860)TGT>TAT	p.C620Y	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	620					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						AAGTTGCAGACAACCTTTATG	0.438													T	8136310	T	T	8136310	3	4	9	1	0	0	0	0	1	0	0	0	1876	478	17	3	1846	3	C17orf68	17	8136310	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08		8136310	73058900	50	622											
NUFIP2	57532	broad.mit.edu	37	chr17	27613998	27613998	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actggaaaaactgggggtggTttaaatagggtccacgagtc	14	6	0	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:27613998T>C	uc002hdy.3	-	2	1103	c.1014A>G	c.(1012-1014)AAA>AAG	p.K338K	NUFIP2_uc002hdx.3_Intron	NM_020772	NP_065823	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein	338						nucleus|polysomal ribosome	protein binding|RNA binding			skin(2)|ovary(1)|breast(1)	4			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			CTGGGGGTGGTTTAAATAGGG	0.413													C	27613998	C	C	27613998	2	2	9	1	0	0	0	0	0	0	0	1	10749	1722	60	4		4	NUFIP2	17	27613998	Silent	SNP	T	TCGA-06-0119-01A-08D-1490-08	19477688	27613998	53581212	51	623											
NF1	4763	broad.mit.edu	37	chr17	29556163	29556163	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatcaacatgactggcttcCtttgtgcccttgggggagtg	14	9	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:29556163C>T	uc002hgg.2	+	21	2863	c.2530C>T	c.(2530-2532)CTT>TTT	p.L844F	NF1_uc002hgh.2_Missense_Mutation_p.L844F|NF1_uc010csn.1_Missense_Mutation_p.L704F|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	844			L -> F (in NF1).|L -> P (in NF1).|L -> R (in NF1; sporadic).		actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GACTGGCTTCCTTTGTGCCCT	0.517			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29556163	T	T	29556163	3	4	9	1	0	0	0	0	1	0	0	0	10356	681	24	3	2673	3	NF1	17	29556163	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	1942165	29556163	51639047	52	624											
GAS2L2	246176	broad.mit.edu	37	chr17	34073181	34073181	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgatatccctttggtggtGgcctcaatggctcggagtct	13	10	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:34073181G>A	uc002hjv.1	-	6	1363	c.1335C>T	c.(1333-1335)GCC>GCT	p.A445A		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	445					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTTTGGTGGTGGCCTCAATGG	0.612													A	34073181	A	A	34073181	2	1	9	1	0	0	0	0	0	0	0	1	6247	1335	47	3		3	GAS2L2	17	34073181	Silent	SNP	G	TCGA-06-0119-01A-08D-1490-08	4517018	34073181	47122029	53	625											
KRT28	162605	broad.mit.edu	37	chr17	38953242	38953242	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcggtgagctggctccgggCgaaagtggctgcgcctgagt	17	11	0	2	rs146193469	byFrequency	TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:38953242C>T	uc002hvh.1	-	5	970	c.904G>A	c.(904-906)GCC>ACC	p.A302T		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	302	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				TGGCTCCGGGCGAAAGTGGCT	0.662													T	38953242	T	T	38953242	3	4	9	1	0	0	0	0	1	0	0	0	8465	768	27	1	506	1	KRT28	17	38953242	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	4880061	38953242	42241968	54	626											
MTMR4	9110	broad.mit.edu	37	chr17	56581411	56581411	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggaaaagggctcagactcacCatgtctgagctgggtgtgta	14	8	3	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:56581411C>A	uc002iwj.2	-	14	1766	c.1656G>T	c.(1654-1656)ATG>ATT	p.M552I		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	552	Myotubularin phosphatase.					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCAGACTCACCATGTCTGAGC	0.483													A	56581411	A	A	56581411	3	1	9	1	0	0	0	0	1	0	0	0	9946	608	21	5	1955	5	MTMR4	17	56581411	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	17628169	56581411	24613799	55	627											
MTMR4	9110	broad.mit.edu	37	chr17	56585838	56585838	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaccctctcacttgtagttgCtgttgatgtgtgagactctc	9	10	2	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:56585838C>T	uc002iwj.2	-	7	652	c.542G>A	c.(541-543)AGC>AAC	p.S181N		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	181	Myotubularin phosphatase.					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTTGTAGTTGCTGTTGATGTG	0.527													T	56585838	T	T	56585838	3	4	9	1	0	0	0	0	1	0	0	0	9946	797	28	3	3097	3	MTMR4	17	56585838	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	4427	56585838	24609372	56	628											
GH1	2688	broad.mit.edu	37	chr17	61995152	61995152	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttggatgccttcctctaggtCctttaggaggtcatagacgt	11	9	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:61995152C>T	uc002jdj.2	-	4	486	c.424G>A	c.(424-426)GAC>AAC	p.D142N	GH1_uc002jdi.2_Missense_Mutation_p.D127N|GH1_uc002jdk.2_Missense_Mutation_p.D102N|GH1_uc002jdl.2_Intron|GH1_uc002jdm.2_Intron|GH1_uc002jdn.2_Intron	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	142					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						TCCTCTAGGTCCTTTAGGAGG	0.587													T	61995152	T	T	61995152	3	4	9	1	0	0	0	0	1	0	0	0	6367	855	30	3	237	3	GH1	17	61995152	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	5409314	61995152	19200058	57	629											
ICAM2	3384	broad.mit.edu	37	chr17	62080238	62080238	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cacgaacagggacagcaacaCcgacaccaccgtgactatga	9	14	0	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:62080238C>A	uc002jdu.3	-	4	929	c.697G>T	c.(697-699)GTG>TTG	p.V233L	C17orf72_uc002jdt.3_3'UTR|C17orf72_uc010wpu.1_3'UTR|C17orf72_uc010wpv.1_3'UTR|C17orf72_uc010wpw.1_3'UTR|ICAM2_uc002jdw.3_Missense_Mutation_p.V233L|ICAM2_uc010ded.2_Missense_Mutation_p.V233L|ICAM2_uc002jdx.3_Missense_Mutation_p.V233L|ICAM2_uc002jdv.3_Missense_Mutation_p.V233L	NM_000873	NP_000864	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2 precursor	233	Helical; (Potential).				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			ovary(1)	1						GACAGCAACACCGACACCACC	0.612													A	62080238	A	A	62080238	3	1	9	1	0	0	0	0	1	0	0	0	7480	507	18	5	134	5	ICAM2	17	62080238	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	85086	62080238	19114972	58	630											
FADS6	283985	broad.mit.edu	37	chr17	72878745	72878745	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaggcaaggcagcctccaCgtgctggagtcccccaggcc	13	15	0	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:72878745C>T	uc002jmd.1	-	3	465	c.453G>A	c.(451-453)ACG>ACA	p.T151T	FADS6_uc010wrn.1_Missense_Mutation_p.R68H	NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	157					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)					GCAGCCTCCACGTGCTGGAGT	0.602													T	72878745	T	T	72878745	2	4	9	1	0	0	0	0	0	0	0	1	5368	523	19	1		1	FADS6	17	72878745	Silent	SNP	C	TCGA-06-0119-01A-08D-1490-08	10798507	72878745	8316465	59	631											
SLC26A11	284129	broad.mit.edu	37	chr17	78195495	78195495	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctgcccagctactccctgCagtggctgaagatggatttc	12	12	0	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr17:78195495C>T	uc002jyb.1	+	3	405	c.136C>T	c.(136-138)CAG>TAG	p.Q46*	SGSH_uc002jxz.3_5'Flank|SGSH_uc002jya.3_5'Flank|SGSH_uc002jxy.2_5'Flank|SGSH_uc010wue.1_5'Flank|SLC26A11_uc002jyc.1_Nonsense_Mutation_p.Q46*|SLC26A11_uc002jyd.1_Nonsense_Mutation_p.Q46*|SLC26A11_uc010dhv.1_Nonsense_Mutation_p.Q46*	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	46	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CTACTCCCTGCAGTGGCTGAA	0.687													T	78195495	T	T	78195495	4	4	9	1	0	0	0	0	0	1	0	0	14516	711	25	3	138	3	SLC26A11	17	78195495	Nonsense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	5316750	78195495	2999715	60	632											
REXO1	57455	broad.mit.edu	37	chr19	1828079	1828079	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ccgggccgagtagttggagaGagggtcatactccaggtctg	16	9	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr19:1828079G>A	uc002lua.3	-	2	804	c.709C>T	c.(709-711)CTC>TTC	p.L237F	REXO1_uc010dsr.1_Missense_Mutation_p.L191F	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	237						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGTTGGAGAGAGGGTCATAC	0.701													A	1828079	A	A	1828079	3	1	9	1	0	0	0	0	1	0	0	0	13241	942	33	3	3016	3	REXO1	19	1828079	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08		1828079	57300904	61	633											
ANO8	57719	broad.mit.edu	37	chr19	17436028	17436028	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccttggcagaggccttctcGgaggaggtggcagggtccag	18	10	1	1	rs144454643		TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr19:17436028G>A	uc002ngf.2	-	17	2988	c.2829C>T	c.(2827-2829)TCC>TCT	p.S943S	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	943	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(3)	3						AGGCCTTCTCGGAGGAGGTGG	0.692													A	17436028	A	A	17436028	2	1	9	1	0	0	0	0	0	0	0	1	703	1103	39	2		2	ANO8	19	17436028	Silent	SNP	G	TCGA-06-0119-01A-08D-1490-08	15607949	17436028	41692955	62	634											
CEACAM21	90273	broad.mit.edu	37	chr19	42083911	42083911	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaccatctccgtgtatacGgtgagtgattcctccgtgcc	9	14	2	2			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr19:42083911G>A	uc002ore.3	+	2	520	c.424G>A	c.(424-426)GAG>AAG	p.E142K	CEACAM21_uc002orc.1_RNA|CEACAM21_uc002ord.1_RNA|CEACAM21_uc002orf.2_RNA|CEACAM21_uc002org.3_Missense_Mutation_p.E142K	NM_001098506	NP_001091976	Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion	142	Extracellular (Potential).					integral to membrane				ovary(1)	1						CCGTGTATACGGTGAGTGATT	0.522													A	42083911	A	A	42083911	3	1	9	1	0	0	0	0	1	0	0	0	3192	1130	39	2	430	2	CEACAM21	19	42083911	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	24647883	42083911	17045072	63	635											
NTF4	4909	broad.mit.edu	37	chr19	49564974	49564974	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgactgcatcgcacacagccAgctcaccccgacgactcgct	8	18	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr19:49564974A>C	uc002pmf.3	-	2	422	c.281T>G	c.(280-282)CTG>CGG	p.L94R	CGB7_uc010yah.1_Intron	NM_006179	NP_006170	P34130	NTF4_HUMAN	neurotrophin 5 preproprotein	94					adult locomotory behavior|epidermis development|ganglion mother cell fate determination|long-term memory|sensory organ boundary specification	endoplasmic reticulum lumen|extracellular region	growth factor activity				0		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		GCACACAGCCAGCTCACCCCG	0.692													C	49564974	C	C	49564974	3	2	9	1	0	0	0	0	1	0	0	0	10697	188	7	5	355	5	NTF4	19	49564974	Missense_Mutation	SNP	A	TCGA-06-0119-01A-08D-1490-08	7481063	49564974	9564009	64	636											
KLK6	5653	broad.mit.edu	37	chr19	51466671	51466671	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttggctgggcgtgccaggCgcaacagcatgatgtcctgg	16	10	0	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr19:51466671C>T	uc002pui.2	-	5	592	c.332G>A	c.(331-333)CGC>CAC	p.R111H	KLK6_uc010eoj.2_Intron|KLK6_uc002puh.2_Missense_Mutation_p.R120H|KLK6_uc002puj.2_Missense_Mutation_p.R4H|KLK6_uc010ycn.1_Missense_Mutation_p.R4H|KLK6_uc002pul.2_Missense_Mutation_p.R111H|KLK6_uc002pum.2_Missense_Mutation_p.R4H	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	111	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		GCGTGCCAGGCGCAACAGCAT	0.617													T	51466671	T	T	51466671	3	4	9	1	0	0	0	0	1	0	0	0	8408	768	27	1	414	1	KLK6	19	51466671	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	1901697	51466671	7662312	65	637											
ZSCAN22	342945	broad.mit.edu	37	chr19	58850588	58850588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcattgagcaccagaggatcCacacgggagagaagccttat	11	10	1	3			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr19:58850588C>T	uc002qsc.2	+	3	1519	c.1372C>T	c.(1372-1374)CAC>TAC	p.H458Y	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	458	C2H2-type 7.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		CCAGAGGATCCACACGGGAGA	0.542													T	58850588	T	T	58850588	3	4	9	1	0	0	0	0	1	0	0	0	18231	594	21	3	1378	3	ZSCAN22	19	58850588	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	7383917	58850588	278395	66	638											
SLC35C2	51006	broad.mit.edu	37	chr20	44979115	44979115	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctccggagcagcagctccAggtcggggctggagcccagc	16	14	0	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr20:44979115A>G	uc002xro.2	-	10	1557	c.1016T>C	c.(1015-1017)CTG>CCG	p.L339P	SLC35C2_uc002xrp.2_Missense_Mutation_p.L318P|SLC35C2_uc002xrq.2_Missense_Mutation_p.L339P|SLC35C2_uc002xrr.2_Missense_Mutation_p.L339P|SLC35C2_uc010zxn.1_Missense_Mutation_p.L204P|SLC35C2_uc010zxo.1_Missense_Mutation_p.L225P|SLC35C2_uc010zxp.1_Missense_Mutation_p.L368P	NM_173179	NP_775271	Q9NQQ7	S35C2_HUMAN	solute carrier family 35, member C2 isoform a	339					transport	integral to membrane				ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CAGCAGCTCCAGGTCGGGGCT	0.617													G	44979115	G	G	44979115	3	3	9	1	0	0	0	0	1	0	0	0	14580	188	7	4	85	4	SLC35C2	20	44979115	Missense_Mutation	SNP	A	TCGA-06-0119-01A-08D-1490-08		44979115	18046405	67	639											
PTGIS	5740	broad.mit.edu	37	chr20	48129691	48129691	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggaggcggtcaccacgtcGcaggttgaattctcgcccgt	14	12	2	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr20:48129691G>A	uc002xut.2	-	8	1186	c.1132C>T	c.(1132-1134)CGA>TGA	p.R378*	PTGIS_uc010zyi.1_Nonsense_Mutation_p.R239*	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	378					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	TCACCACGTCGCAGGTTGAAT	0.612													A	48129691	A	A	48129691	4	1	9	1	0	0	0	0	0	1	0	0	12752	1095	38	1	382	1	PTGIS	20	48129691	Nonsense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	3150576	48129691	14895829	68	640											
PKDREJ	10343	broad.mit.edu	37	chr22	46657006	46657006	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggaagaaggaaagactgatcGatgaggtgttttcggagatt	15	3	0	5			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chr22:46657006G>A	uc003bhh.2	-	1	2214	c.2214C>T	c.(2212-2214)ATC>ATT	p.I738I		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	738	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AAGACTGATCGATGAGGTGTT	0.408													A	46657006	A	A	46657006	2	1	9	1	0	0	0	0	0	0	0	1	11970	1048	37	2		2	PKDREJ	22	46657006	Silent	SNP	G	TCGA-06-0119-01A-08D-1490-08		46657006	4647560	69	641											
ARSE	415	broad.mit.edu	37	chrX	2867744	2867744	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aatgatcactggctgactcaCagttgagacccagatgccat	9	11	2	4			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:2867744C>G	uc004crc.3	-	6	705	c.455G>C	c.(454-456)TGT>TCT	p.C152S	ARSE_uc011mhi.1_Missense_Mutation_p.C98S|ARSE_uc011mhh.1_Missense_Mutation_p.C177S	NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	152					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCTGACTCACAGTTGAGACC	0.483													G	2867744	G	G	2867744	3	3	9	1	0	0	0	0	1	0	0	0	990	478	17	5	1338	5	ARSE	23	2867744	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08		2867744	152402816	70	642											
MXRA5	25878	broad.mit.edu	37	chrX	3235366	3235366	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcggccacgcactcatagCgcccgctgtccttgggcgcg	14	16	1	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:3235366C>T	uc004crg.3	-	6	6513	c.6356G>A	c.(6355-6357)CGC>CAC	p.R2119H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2119	Ig-like C2-type 5.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCACTCATAGCGCCCGCTGTC	0.662													T	3235366	T	T	3235366	3	4	9	1	0	0	0	0	1	0	0	0	10003	768	27	1	2138	1	MXRA5	23	3235366	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	367622	3235366	152035194	71	643											
MAGEB1	4112	broad.mit.edu	37	chrX	30269233	30269233	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatgcctctcctgggtgtgaTcttcttaaagggcaactctg	11	10	4	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:30269233T>C	uc004dcc.2	+	4	943	c.623T>C	c.(622-624)ATC>ACC	p.I208T	MAGEB1_uc004dcd.2_Missense_Mutation_p.I208T|MAGEB1_uc004dce.2_Missense_Mutation_p.I208T	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	208	MAGE.										0						CTGGGTGTGATCTTCTTAAAG	0.488													C	30269233	C	C	30269233	3	2	9	1	0	0	0	0	1	0	0	0	9172	1435	50	4	625	4	MAGEB1	23	30269233	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08	27033867	30269233	125001327	72	644											
FAM47A	158724	broad.mit.edu	37	chrX	34148878	34148878	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgacgagtcttgggaggctcCgagcggagactggacgtccg	17	11	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:34148878C>T	uc004ddg.2	-	1	1551	c.1518G>A	c.(1516-1518)TCG>TCA	p.S506S		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	506			Missing.							ovary(4)|central_nervous_system(1)	5						TGGGAGGCTCCGAGCGGAGAC	0.652													T	34148878	T	T	34148878	2	4	9	1	0	0	0	0	0	0	0	1	5569	639	23	2		2	FAM47A	23	34148878	Silent	SNP	C	TCGA-06-0119-01A-08D-1490-08	3879645	34148878	121121682	73	645											
PHF16	9767	broad.mit.edu	37	chrX	46884151	46884151	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagctgagaaggtaaaggacGttctgtttatccgaccccgg	12	9	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:46884151G>A	uc004dgx.2	+	5	361	c.310G>A	c.(310-312)GTT>ATT	p.V104I	PHF16_uc004dgy.2_Missense_Mutation_p.V104I	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	104					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						GGTAAAGGACGTTCTGTTTAT	0.448													A	46884151	A	A	46884151	3	1	9	1	0	0	0	0	1	0	0	0	11827	1145	40	1	324	1	PHF16	23	46884151	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	12735273	46884151	108386409	74	646											
RBM10	8241	broad.mit.edu	37	chrX	47041361	47041361	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accccctagctgttcccgacGtctctacctaccagtacgat	6	17	1	0			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:47041361G>A	uc004dhf.2	+	16	2084	c.1705G>A	c.(1705-1707)GTC>ATC	p.V569I	RBM10_uc004dhg.2_Missense_Mutation_p.V491I|RBM10_uc004dhh.2_Missense_Mutation_p.V568I|RBM10_uc010nhq.2_Missense_Mutation_p.V492I|RBM10_uc004dhi.2_Missense_Mutation_p.V634I	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	569	Tyr-rich.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						TGTTCCCGACGTCTCTACCTA	0.577													A	47041361	A	A	47041361	3	1	9	1	0	0	0	0	1	0	0	0	13111	1145	40	1	1763	1	RBM10	23	47041361	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	157210	47041361	108229199	75	647											
ARL13A	392509	broad.mit.edu	37	chrX	100240808	100240808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcccatgggcttgttttcGtcctggattccagtgacata	11	10	0	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:100240808G>A	uc004ego.2	+	4	399	c.283G>A	c.(283-285)GTC>ATC	p.V95I	ARL13A_uc011mrf.1_Missense_Mutation_p.V95I|ARL13A_uc010nng.2_Missense_Mutation_p.V95I	NM_001012990	NP_001013008	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13 isoform a	95							GTP binding			ovary(1)	1						GCTTGTTTTCGTCCTGGATTC	0.468													A	100240808	A	A	100240808	3	1	9	1	0	0	0	0	1	0	0	0	928	1145	40	1	293	1	ARL13A	23	100240808	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	53199447	100240808	55029752	76	648											
HNRNPH2	3188	broad.mit.edu	37	chrX	100667805	100667805	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatgtctgatcatagatacGgagatggtgggtccagtttc	13	6	2	3			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:100667805G>A	uc004ehm.2	+	2	999	c.829G>A	c.(829-831)GGA>AGA	p.G277R	HNRNPH2_uc004ehn.2_Missense_Mutation_p.G277R	NM_019597	NP_062543	P55795	HNRH2_HUMAN	heterogeneous nuclear ribonucleoprotein H2	277	2 X 16 AA Gly-rich approximate repeats.				nuclear mRNA splicing, via spliceosome	actin cytoskeleton|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TCATAGATACGGAGATGGTGG	0.428													A	100667805	A	A	100667805	3	1	9	1	0	0	0	0	1	0	0	0	7267	1117	39	2	831	2	HNRNPH2	23	100667805	Missense_Mutation	SNP	G	TCGA-06-0119-01A-08D-1490-08	426997	100667805	54602755	77	649											
SLC6A14	11254	broad.mit.edu	37	chrX	115586616	115586616	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcttgctggtttgtaattaCgcctatccttttgattgtaa	8	7	0	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:115586616C>T	uc004eqi.2	+	12	1702	c.1598C>T	c.(1597-1599)ACG>ATG	p.T533M		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	533	Helical; Name=11; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TTTGTAATTACGCCTATCCTT	0.348													T	115586616	T	T	115586616	3	4	9	1	0	0	0	0	1	0	0	0	14677	536	19	1	1644	1	SLC6A14	23	115586616	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	14918811	115586616	39683944	78	650											
RHOXF1	158800	broad.mit.edu	37	chrX	119249400	119249400	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gggcacatcagggtattgagTgtgtcggaaaacactttcca	12	8	1	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:119249400T>A	uc004esk.1	-	1	448	c.373A>T	c.(373-375)ACT>TCT	p.T125S	uc004esi.1_Intron	NM_139282	NP_644811	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	125	Homeobox.				gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGGTATTGAGTGTGTCGGAAA	0.577													A	119249400	A	A	119249400	3	1	9	1	0	0	0	0	1	0	0	0	13347	1696	59	5	193	5	RHOXF1	23	119249400	Missense_Mutation	SNP	T	TCGA-06-0119-01A-08D-1490-08	3662784	119249400	36021160	79	651											
IRAK1	3654	broad.mit.edu	37	chrX	153283486	153283486	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagacggtcctccagggagcCgttgggcaggaagccgtaca	16	11	0	1			TCGA-06-0119-01A-08D-1490-08	TCGA-06-0119-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cda6181-c62b-4ced-a543-d6138fd2e94a	8fc02285-7cee-43ed-8656-279e597967ba	g.chrX:153283486C>T	uc004fjs.1	-	7	959	c.880G>A	c.(880-882)GGC>AGC	p.G294S	IRAK1_uc004fjr.1_Missense_Mutation_p.G294S|IRAK1_uc004fjt.1_Missense_Mutation_p.G294S|IRAK1_uc010nur.2_Intron|IRAK1_uc004fju.2_Missense_Mutation_p.G320S	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	294	Protein kinase.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGGGAGCCGTTGGGCAGG	0.612													T	153283486	T	T	153283486	3	4	9	1	0	0	0	0	1	0	0	0	7821	652	23	2	1290	2	IRAK1	23	153283486	Missense_Mutation	SNP	C	TCGA-06-0119-01A-08D-1490-08	34034086	153283486	1987074	80	652											
MTOR	2475	broad.mit.edu	37	chr1	11174395	11174395	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgtccatcagcctccagttcAgcaaggggtcatagacaaag	10	11	3	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:11174395A>T	uc001asd.2	-	53	7401	c.7280T>A	c.(7279-7281)CTG>CAG	p.L2427Q	MTOR_uc001asc.2_Missense_Mutation_p.L632Q	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2427	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CCTCCAGTTCAGCAAGGGGTC	0.388													T	11174395	T	T	11174395	3	4	10	1	0	0	0	0	1	0	0	0	9954	188	7	5	393	5	MTOR	1	11174395	Missense_Mutation	SNP	A	TCGA-06-0122-01A-01D-1490-08		11174395	238076226	1	653											
UBR4	23352	broad.mit.edu	37	chr1	19492180	19492180	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaactcctccatagctttaCgagcctggctactttccagc	6	14	0	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:19492180C>T	uc001bbi.2	-	30	4185	c.4181G>A	c.(4180-4182)CGT>CAT	p.R1394H	UBR4_uc001bbm.1_Missense_Mutation_p.R605H	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1394			R -> H (in a breast cancer sample; somatic mutation).		interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding	p.R1394H(2)		kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CATAGCTTTACGAGCCTGGCT	0.433													T	19492180	T	T	19492180	3	4	10	1	0	0	0	0	1	0	0	0	16901	536	19	1	11678	1	UBR4	1	19492180	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	8317785	19492180	229758441	2	654											
EYA3	2140	broad.mit.edu	37	chr1	28362074	28362074	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaaaggaggtagtccataCgtttgggttgcctgagggta	14	7	0	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:28362074C>T	uc001bpi.1	-	6	507	c.342G>A	c.(340-342)ACG>ACA	p.T114T	EYA3_uc010ofs.1_Silent_p.T61T|EYA3_uc010oft.1_Silent_p.T114T|EYA3_uc001bpj.2_Silent_p.T114T|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3	114					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		GTAGTCCATACGTTTGGGTTG	0.428													T	28362074	T	T	28362074	2	4	10	1	0	0	0	0	0	0	0	1	5330	523	19	1		1	EYA3	1	28362074	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	8869894	28362074	220888547	3	655											
ZSCAN20	7579	broad.mit.edu	37	chr1	33960310	33960310	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactcaccagagaattcacaCgggggaaaagccctataaat	8	11	2	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:33960310C>T	uc001bxj.3	+	8	2533	c.2366C>T	c.(2365-2367)ACG>ATG	p.T789M	ZSCAN20_uc009vui.2_Missense_Mutation_p.T788M	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	789					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGAATTCACACGGGGGAAAAG	0.438													T	33960310	T	T	33960310	3	4	10	1	0	0	0	0	1	0	0	0	18229	536	19	1	2392	1	ZSCAN20	1	33960310	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	5598236	33960310	215290311	4	656											
EPHA10	284656	broad.mit.edu	37	chr1	38227491	38227491	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gattttgcggggccggctgcCgcctaggcggggacgcccac	17	14	0	0	rs146430998		TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:38227491C>T	uc009vvi.2	-	3	522	c.436G>A	c.(436-438)GGC>AGC	p.G146S	EPHA10_uc001cbw.3_Missense_Mutation_p.G146S	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	146	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGCCGGCTGCCGCCTAGGCGG	0.662													T	38227491	T	T	38227491	3	4	10	1	0	0	0	0	1	0	0	0	5166	652	23	2	2688	2	EPHA10	1	38227491	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	4267181	38227491	211023130	5	657											
SGIP1	84251	broad.mit.edu	37	chr1	67194966	67194966	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgtatcgttaagattaccGgagaaatggtgttgtcattt	11	4	1	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:67194966G>A	uc001dcr.2	+	20	1979	c.1762G>A	c.(1762-1764)GGA>AGA	p.G588R	SGIP1_uc010opd.1_Missense_Mutation_p.G188R|SGIP1_uc001dcs.2_Missense_Mutation_p.G188R|SGIP1_uc001dct.2_Missense_Mutation_p.G190R|SGIP1_uc009wat.2_Missense_Mutation_p.G382R|SGIP1_uc001dcu.2_Missense_Mutation_p.G93R	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	588					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TAAGATTACCGGAGAAATGGT	0.423													A	67194966	A	A	67194966	3	1	10	1	0	0	0	0	1	0	0	0	14206	1117	39	2	1840	2	SGIP1	1	67194966	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	28967475	67194966	182055655	6	658											
SPAG17	200162	broad.mit.edu	37	chr1	118548038	118548038	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taccaaaggtgcactttaccTgaaaagtgtttccctcagga	8	10	1	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:118548038T>G	uc001ehk.2	-	32	4843	c.4775A>C	c.(4774-4776)CAG>CCG	p.Q1592P		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1592						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GCACTTTACCTGAAAAGTGTT	0.448													G	118548038	G	G	118548038	3	3	10	1	0	0	0	0	1	0	0	0	14979	1594	55	5	1964	5	SPAG17	1	118548038	Missense_Mutation	SNP	T	TCGA-06-0122-01A-01D-1490-08	51353072	118548038	130702583	7	659											
APH1A	51107	broad.mit.edu	37	chr1	150239482	150239482	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtctccaactcaccagtcccGatgtcagtaggtgactccca	8	15	3	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:150239482G>A	uc001ety.1	-	5	924	c.602C>T	c.(601-603)TCG>TTG	p.S201L	APH1A_uc010pbx.1_Missense_Mutation_p.S131L|APH1A_uc001etz.1_Missense_Mutation_p.S201L|APH1A_uc001eua.1_Missense_Mutation_p.S201L|APH1A_uc010pby.1_Missense_Mutation_p.S144L|APH1A_uc001eub.1_Missense_Mutation_p.S85L|APH1A_uc010pbz.1_Missense_Mutation_p.S85L	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	201	Helical; Name=6; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACCAGTCCCGATGTCAGTAG	0.507													A	150239482	A	A	150239482	3	1	10	1	0	0	0	0	1	0	0	0	771	1059	37	2	218	2	APH1A	1	150239482	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	31691444	150239482	99011139	8	660											
FLG2	388698	broad.mit.edu	37	chr1	152325713	152325713	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgtgagtgtgtcctgaatGtgtgtgcgagccccctgagt	15	10	0	3			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:152325713G>A	uc001ezw.3	-	3	4622	c.4549C>T	c.(4549-4551)CAT>TAT	p.H1517Y	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1517							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGAATGTGTGTGCGAG	0.498													A	152325713	A	A	152325713	3	1	10	1	0	0	0	0	1	0	0	0	5923	1377	48	3	2630	3	FLG2	1	152325713	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	2086231	152325713	96924908	9	661											
PPOX	5498	broad.mit.edu	37	chr1	161138221	161138221	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agtcctagtctcacccttaaGgtggcgtctctagccatgga	10	12	2	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:161138221G>T	uc001fyj.2	+	6	762	c.472_splice	c.e6-1	p.V158_splice	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Splice_Site_p.V158_splice|PPOX_uc001fyl.2_Splice_Site_p.V124_splice|PPOX_uc001fym.2_Intron|PPOX_uc001fyk.2_Splice_Site|PPOX_uc001fyh.2_Splice_Site|PPOX_uc010pkg.1_Translation_Start_Site|PPOX_uc009wuc.1_Splice_Site|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Translation_Start_Site	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase						heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TCACCCTTAAGGTGGCGTCTC	0.522									Porphyria_Variegata				T	161138221	T	T	161138221	5	4	10	1	0	0	0	0	0	0	1	0	12348	1014	35	5	489	5	PPOX	1	161138221	Splice_Site	SNP	G	TCGA-06-0122-01A-01D-1490-08	8812508	161138221	88112400	10	662											
HMCN1	83872	broad.mit.edu	37	chr1	186092143	186092143	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgtggacaagcccatcaCgttatcctgtgaagcagatg	11	10	1	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:186092143C>T	uc001grq.1	+	81	12519	c.12290C>T	c.(12289-12291)ACG>ATG	p.T4097M		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4097	Ig-like C2-type 40.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AAGCCCATCACGTTATCCTGT	0.433													T	186092143	T	T	186092143	3	4	10	1	0	0	0	0	1	0	0	0	7220	536	19	1	12612	1	HMCN1	1	186092143	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	24953922	186092143	63158478	11	663											
RYR2	6262	broad.mit.edu	37	chr1	237811774	237811774	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtggaacctgacatgtctgCggggttttgcccagatcaca	13	10	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr1:237811774C>T	uc001hyl.1	+	49	7493	c.7373C>T	c.(7372-7374)GCG>GTG	p.A2458V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2458	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GACATGTCTGCGGGGTTTTGC	0.458													T	237811774	T	T	237811774	3	4	10	1	0	0	0	0	1	0	0	0	13769	768	27	1	7567	1	RYR2	1	237811774	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	51719631	237811774	11438847	12	664											
PRKD3	23683	broad.mit.edu	37	chr2	37516578	37516578	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gtcctggtaaagatacatttGacagacgtctctttcttact	7	9	2	3			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:37516578G>C	uc002rqd.2	-	4	1193	c.638C>G	c.(637-639)TCA>TGA	p.S213*	PRKD3_uc002rqf.1_Nonsense_Mutation_p.S213*	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	213					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				AGATACATTTGACAGACGTCT	0.413													C	37516578	C	C	37516578	4	2	10	1	0	0	0	0	0	1	0	0	12520	1294	45	5	2094	5	PRKD3	2	37516578	Nonsense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08		37516578	205682795	13	665											
PCDP1	200373	broad.mit.edu	37	chr2	120369295	120369295	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacagaagttagccataaaCgggttgttcgcaatcaagaa	9	7	1	2	rs149304410		TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:120369295C>T	uc002tmb.2	+	14	1522	c.430C>T	c.(430-432)CGG>TGG	p.R144W	PCDP1_uc010yyq.1_Missense_Mutation_p.R274W	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	430						cilium	calmodulin binding				0	Colorectal(110;0.196)					TAGCCATAAACGGGTTGTTCG	0.333													T	120369295	T	T	120369295	3	4	10	1	0	0	0	0	1	0	0	0	11572	527	19	1	448	1	PCDP1	2	120369295	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	82852717	120369295	122830078	14	666											
LRP1B	53353	broad.mit.edu	37	chr2	141072506	141072506	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgacaatgaaatatttacctAgaactgatggtacgcaagtt	8	6	0	4			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:141072506A>G	uc002tvj.1	-	83	13775	c.12803T>C	c.(12802-12804)CTA>CCA	p.L4268P		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4268	Extracellular (Potential).|EGF-like 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATATTTACCTAGAACTGATGG	0.353										TSP Lung(27;0.18)			G	141072506	G	G	141072506	3	3	10	1	0	0	0	0	1	0	0	0	8955	420	15	4	1032	4	LRP1B	2	141072506	Missense_Mutation	SNP	A	TCGA-06-0122-01A-01D-1490-08	20703211	141072506	102126867	15	667											
COBLL1	22837	broad.mit.edu	37	chr2	165578701	165578701	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcgggggcagtggagcccGcctcttcttgggtgcatccg	15	13	2	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:165578701G>A	uc010zcw.1	-	9	1202	c.1078C>T	c.(1078-1080)CGG>TGG	p.R360W	COBLL1_uc002ucp.2_Missense_Mutation_p.R294W|COBLL1_uc002ucq.2_Missense_Mutation_p.R294W|COBLL1_uc010zcx.1_Missense_Mutation_p.R340W|COBLL1_uc002ucs.1_RNA|COBLL1_uc002uco.2_Missense_Mutation_p.R63W	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	332	KKRRAP 1.									ovary(2)|pancreas(1)	3						AGTGGAGCCCGCCTCTTCTTG	0.522													A	165578701	A	A	165578701	3	1	10	1	0	0	0	0	1	0	0	0	3654	1086	38	1	2656	1	COBLL1	2	165578701	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	24506195	165578701	77620672	16	668											
SCN1A	6323	broad.mit.edu	37	chr2	166850847	166850847	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaccatcattgtgaccatgTtaagacagatgagaatcatg	8	9	2	4			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:166850847T>C	uc010zcz.1	-	25	4646	c.4628A>G	c.(4627-4629)AAC>AGC	p.N1543S		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1554	Helical; Name=S1 of repeat IV; (By similarity).|IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGTGACCATGTTAAGACAGAT	0.378													C	166850847	C	C	166850847	3	2	10	1	0	0	0	0	1	0	0	0	13914	1725	60	4	1376	4	SCN1A	2	166850847	Missense_Mutation	SNP	T	TCGA-06-0122-01A-01D-1490-08	1272146	166850847	76348526	17	669											
TTN	7273	broad.mit.edu	37	chr2	179476875	179476875	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaccactgccagggcgtaggGtggtccaggagtggctgaaa	16	9	0	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:179476875G>C	uc010zfg.1	-	216	42783	c.42559C>G	c.(42559-42561)CCC>GCC	p.P14187A	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P7882A|TTN_uc010zfi.1_Missense_Mutation_p.P7815A|TTN_uc010zfj.1_Missense_Mutation_p.P7690A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15114							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGGCGTAGGGTGGTCCAGGA	0.418													C	179476875	C	C	179476875	3	2	10	1	0	0	0	0	1	0	0	0	16732	1261	44	5	57814	5	TTN	2	179476875	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	12626028	179476875	63722498	18	670											
TTN	7273	broad.mit.edu	37	chr2	179597777	179597777	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctgcaattttgcagtccaGtctgcaggtaccattaacaa	8	11	1	0	rs72648936		TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:179597777G>A	uc010zfg.1	-	52	12618	c.12394C>T	c.(12394-12396)CTG>TTG	p.L4132L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.L793L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5059							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCAGTCCAGTCTGCAGGTA	0.468													A	179597777	A	A	179597777	2	1	10	1	0	0	0	0	0	0	0	1	16732	1020	36	3		3	TTN	2	179597777	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	120902	179597777	63601596	19	671											
TTN	7273	broad.mit.edu	37	chr2	179599243	179599243	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaaccagctaatttcaaatGgtccagtgcctgagacttca	8	10	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:179599243G>A	uc010zfg.1	-	49	11800	c.11576C>T	c.(11575-11577)CCA>CTA	p.P3859L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P520L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4786							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTTCAAATGGTCCAGTGCC	0.393													A	179599243	A	A	179599243	3	1	10	1	0	0	0	0	1	0	0	0	16732	1348	47	3	89465	3	TTN	2	179599243	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	1466	179599243	63600130	20	672											
IHH	3549	broad.mit.edu	37	chr2	219920562	219920562	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccggcagggaagcagccGcccgtcttggctgcggccga	16	15	1	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:219920562G>A	uc002vjo.1	-	3	603	c.603C>T	c.(601-603)GGC>GGT	p.G201G		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	201					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAAGCAGCCGCCCGTCTTGG	0.672													A	219920562	A	A	219920562	2	1	10	1	0	0	0	0	0	0	0	1	7607	1074	38	1		1	IHH	2	219920562	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	40321319	219920562	23278811	21	673											
ACCN4	55515	broad.mit.edu	37	chr2	220396799	220396799	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccctacatccaccagctgggGttcggggtgtccccaggctt	12	15	0	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:220396799G>C	uc002vma.2	+	3	1199	c.1185G>C	c.(1183-1185)GGG>GGC	p.G395G	ACCN4_uc010fwi.1_Silent_p.G395G|ACCN4_uc010fwj.1_Silent_p.G395G|ACCN4_uc002vly.1_Silent_p.G395G|ACCN4_uc002vlz.2_Silent_p.G395G|ACCN4_uc002vmb.2_Silent_p.G49G	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	395	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		ACCAGCTGGGGTTCGGGGTGT	0.617													C	220396799	C	C	220396799	2	2	10	1	0	0	0	0	0	0	0	1	131	1248	44	5		5	ACCN4	2	220396799	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	476237	220396799	22802574	22	674											
GIGYF2	26058	broad.mit.edu	37	chr2	233710565	233710565	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagtggtgtgaacagatgctTcatgcccttaatacggcaaa	10	9	1	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:233710565T>C	uc002vti.3	+	28	3766	c.3429T>C	c.(3427-3429)CTT>CTC	p.L1143L	GIGYF2_uc002vtj.3_Silent_p.L1164L|GIGYF2_uc002vtk.3_Silent_p.L1143L|GIGYF2_uc002vth.3_Silent_p.L1137L|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc002vtq.3_Silent_p.L476L	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	1143					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		AACAGATGCTTCATGCCCTTA	0.249													C	233710565	C	C	233710565	2	2	10	1	0	0	0	0	0	0	0	1	6378	1770	62	4		4	GIGYF2	2	233710565	Silent	SNP	T	TCGA-06-0122-01A-01D-1490-08	13313766	233710565	9488808	23	675											
UGT1A6	54578	broad.mit.edu	37	chr2	234602272	234602272	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accacatgactttttcccaaCgagtggccaacttccttgtt	6	13	0	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr2:234602272C>T	uc002vuv.3	+	1	761	c.622C>T	c.(622-624)CGA>TGA	p.R208*	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Nonsense_Mutation_p.R208*	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	208					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		TTTTTCCCAACGAGTGGCCAA	0.448													T	234602272	T	T	234602272	4	4	10	1	0	0	0	0	0	1	0	0	16946	528	19	1	624	1	UGT1A6	2	234602272	Nonsense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	891707	234602272	8597101	24	676											
OR5K3	403277	broad.mit.edu	37	chr3	98109856	98109856	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacagactgctttcttctggCggcaatggcctatgactgct	10	11	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr3:98109856C>T	uc011bgw.1	+	1	347	c.347C>T	c.(346-348)GCG>GTG	p.A116V		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTCTTCTGGCGGCAATGGCC	0.453													T	98109856	T	T	98109856	3	4	10	1	0	0	0	0	1	0	0	0	11168	768	27	1	349	1	OR5K3	3	98109856	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08		98109856	99912574	25	677											
RTP1	132112	broad.mit.edu	37	chr3	186917654	186917654	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctgcgaggcctgccaggaGggcatcgtgcactggaagcc	15	12	1	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr3:186917654G>A	uc003frg.2	+	2	618	c.588G>A	c.(586-588)GAG>GAA	p.E196E		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	196	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		CCTGCCAGGAGGGCATCGTGC	0.692													A	186917654	A	A	186917654	2	1	10	1	0	0	0	0	0	0	0	1	13733	991	35	3		3	RTP1	3	186917654	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	88807798	186917654	11104776	26	678											
ADAMTS16	170690	broad.mit.edu	37	chr5	5262831	5262831	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tttcaagtaaatatgtccttCtgcaatcccaagacacgacc	5	12	2	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr5:5262831C>A	uc003jdl.2	+	18	2862	c.2724C>A	c.(2722-2724)TTC>TTA	p.F908L	ADAMTS16_uc003jdk.1_Missense_Mutation_p.F908L	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	908	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ATATGTCCTTCTGCAATCCCA	0.498													A	5262831	A	A	5262831	3	1	10	1	0	0	0	0	1	0	0	0	261	912	32	5	2794	5	ADAMTS16	5	5262831	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08		5262831	175652429	27	679											
PAPD7	11044	broad.mit.edu	37	chr5	6737716	6737717	+	Frame_Shift_Del	DEL	TG	-	-													gtggtgaaacggatcgaaacTgtggtgaaagacctttggcc							TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr5:6737716_6737717delTG	uc003jdx.1	+	2	189_190	c.60_61delTG	c.(58-63)ACTGTGfs	p.T20fs	PAPD7_uc011cmn.1_Frame_Shift_Del_p.T11fs	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	20_21					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						GGATCGAAACTGTGGTGAAAGA	0.436													-	6737717	-	-	6737716	7	5	10	1	0	1	0	1	0	0	0	0	11426	1567	55	0	62	0	PAPD7	5	6737716	Frame_Shift_Del	DEL	TG	TCGA-06-0122-01A-01D-1490-08	1474885	6737716	174177544	28	680											
NIPBL	25836	broad.mit.edu	37	chr5	37051937	37051937	+	Frame_Shift_Del	DEL	G	-	-													gaacctgctatgcggaacaaGgctgatcagcaacttgtgga							TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr5:37051937delG	uc003jkl.3	+	41	7510	c.7011delG	c.(7009-7011)AAGfs	p.K2337fs	NIPBL_uc003jkk.3_Frame_Shift_Del_p.K2337fs|NIPBL_uc003jkn.2_Frame_Shift_Del_p.K30fs	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2337	HEAT 5.				brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TGCGGAACAAGGCTGATCAGC	0.318													-	37051937	-	-	37051937	7	5	10	1	0	1	0	1	0	0	0	0	10428	991	35	0	7169	0	NIPBL	5	37051937	Frame_Shift_Del	DEL	G	TCGA-06-0122-01A-01D-1490-08	30314221	37051937	143863323	29	681											
HCN1	348980	broad.mit.edu	37	chr5	45462085	45462085	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aattctcaccactgcactggCgagatcatatgtcatgtgga	9	10	3	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr5:45462085C>G	uc003jok.2	-	3	899	c.874G>C	c.(874-876)GCC>CCC	p.A292P		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	292	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ACTGCACTGGCGAGATCATAT	0.378													G	45462085	G	G	45462085	3	3	10	1	0	0	0	0	1	0	0	0	6996	768	27	5	1822	5	HCN1	5	45462085	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	8410148	45462085	135453175	30	682											
PCDHB4	56131	broad.mit.edu	37	chr5	140502131	140502131	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcacattctcactcgaaatcAtagtgagggcaagaaatacc	7	10	3	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr5:140502131A>T	uc003lip.1	+	1	551	c.551A>T	c.(550-552)CAT>CTT	p.H184L		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	184	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGAAATCATAGTGAGGGC	0.478													T	140502131	T	T	140502131	3	4	10	1	0	0	0	0	1	0	0	0	11544	217	8	5	553	5	PCDHB4	5	140502131	Missense_Mutation	SNP	A	TCGA-06-0122-01A-01D-1490-08	95040046	140502131	40413129	31	683											
EZR	7430	broad.mit.edu	37	chr6	159206603	159206603	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gggattctccttcctgacctCctgggcagacacctgcacga	10	15	1	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr6:159206603C>A	uc003qrt.3	-	4	420	c.205G>T	c.(205-207)GAG>TAG	p.E69*	EZR_uc011efs.1_Nonsense_Mutation_p.E37*|EZR_uc003qru.3_Nonsense_Mutation_p.E69*	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	69	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TTCCTGACCTCCTGGGCAGAC	0.537													A	159206603	A	A	159206603	4	1	10	1	0	0	0	0	0	1	0	0	5335	864	30	5	1595	5	EZR	6	159206603	Nonsense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08		159206603	11908464	32	684											
VOPP1	81552	broad.mit.edu	37	chr7	55588786	55588786	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tataataggttggatagagtCcttcgaaataccagcaatgc	9	7	0	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr7:55588786C>T	uc003tqs.2	-	2	275	c.92G>A	c.(91-93)GGA>GAA	p.G31E	VOPP1_uc003tqq.2_Missense_Mutation_p.G22E|VOPP1_uc010kzh.2_Missense_Mutation_p.G28E|VOPP1_uc010kzi.2_Missense_Mutation_p.G14E|VOPP1_uc011kcr.1_5'UTR	NM_030796	NP_110423	Q96AW1	VOPP1_HUMAN	EGFR-coamplified and overexpressed protein	31	Extracellular (Potential).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity				0						TGGATAGAGTCCTTCGAAATA	0.408													T	55588786	T	T	55588786	3	4	10	1	0	0	0	0	1	0	0	0	17181	855	30	3	442	3	VOPP1	7	55588786	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08		55588786	103549877	33	685											
PCLO	27445	broad.mit.edu	37	chr7	82390725	82390725	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgtaatatttctgcattggAgaatttcaactattagttgt	7	4	2	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr7:82390725A>G	uc003uhx.2	-	23	15381	c.15092T>C	c.(15091-15093)CTC>CCC	p.L5031P		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4954	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCTGCATTGGAGAATTTCAAC	0.308													G	82390725	G	G	82390725	3	3	10	1	0	0	0	0	1	0	0	0	11583	304	11	4	348	4	PCLO	7	82390725	Missense_Mutation	SNP	A	TCGA-06-0122-01A-01D-1490-08	26801939	82390725	76747938	34	686											
PCLO	27445	broad.mit.edu	37	chr7	82586181	82586181	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttccatcggaagaatatcccGtgtcgctcagaccttggggg	12	11	1	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr7:82586181G>A	uc003uhx.2	-	5	4377	c.4088C>T	c.(4087-4089)ACG>ATG	p.T1363M	PCLO_uc003uhv.2_Missense_Mutation_p.T1363M	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1294					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGAATATCCCGTGTCGCTCAG	0.428													A	82586181	A	A	82586181	3	1	10	1	0	0	0	0	1	0	0	0	11583	1145	40	1	11441	1	PCLO	7	82586181	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	195456	82586181	76552482	35	687											
TFEC	22797	broad.mit.edu	37	chr7	115614228	115614228	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtctgaaagcacttactgttCtttgcattagcagaggagag	11	7	2	3			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr7:115614228C>T	uc003vhj.1	-	3	447	c.263G>A	c.(262-264)AGA>AAA	p.R88K	TFEC_uc003vhk.1_Intron|TFEC_uc003vhl.3_Intron|TFEC_uc011kmw.1_Missense_Mutation_p.R178K	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	88	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			ACTTACTGTTCTTTGCATTAG	0.358													T	115614228	T	T	115614228	3	4	10	1	0	0	0	0	1	0	0	0	15799	913	32	3	804	3	TFEC	7	115614228	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	33028047	115614228	43524435	36	688											
CNTNAP2	26047	broad.mit.edu	37	chr7	147259316	147259316	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atcctgatggcagcggacctCtggggcctctgaaagtttac	12	11	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr7:147259316C>T	uc003weu.1	+	12	2380	c.1864C>T	c.(1864-1866)CTG>TTG	p.L622L		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	622	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAGCGGACCTCTGGGGCCTCT	0.408										HNSCC(39;0.1)			T	147259316	T	T	147259316	2	4	10	1	0	0	0	0	0	0	0	1	3647	912	32	3		3	CNTNAP2	7	147259316	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	31645088	147259316	11879347	37	689											
DEFB135	613209	broad.mit.edu	37	chr8	11842018	11842018	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cggccaaaatgtctaaaaaaCgaacaatatcgtattttgtg	7	7	1	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr8:11842018C>G	uc003wuw.1	+	2	153	c.153C>G	c.(151-153)AAC>AAG	p.N51K		NM_001033017	NP_001028189	Q30KP9	DB135_HUMAN	beta-defensin 135 precursor	51					defense response to bacterium	extracellular region					0						GTCTAAAAAACGAACAATATC	0.383													G	11842018	G	G	11842018	3	3	10	1	0	0	0	0	1	0	0	0	4419	535	19	5	159	5	DEFB135	8	11842018	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08		11842018	134522004	38	690											
SLCO5A1	81796	broad.mit.edu	37	chr8	70667821	70667821	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagcttttttgggaaagtaaAcattgggaatatcacaagaa	9	4	1	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr8:70667821A>T	uc003xyl.2	-	4	1803	c.1096T>A	c.(1096-1098)TTT>ATT	p.F366I	SLCO5A1_uc010lzb.2_Missense_Mutation_p.F366I|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.F366I|SLCO5A1_uc010lzc.2_Missense_Mutation_p.F366I	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	366	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GGGAAAGTAAACATTGGGAAT	0.353													T	70667821	T	T	70667821	3	4	10	1	0	0	0	0	1	0	0	0	14731	43	2	5	1478	5	SLCO5A1	8	70667821	Missense_Mutation	SNP	A	TCGA-06-0122-01A-01D-1490-08	58825803	70667821	75696201	39	691											
KCNB2	9312	broad.mit.edu	37	chr8	73848476	73848476	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgtgctgcagttccaaaacGtgaggcgcgtggtccagatc	14	11	0	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr8:73848476G>A	uc003xzb.2	+	3	1474	c.886G>A	c.(886-888)GTG>ATG	p.V296M		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	296					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GTTCCAAAACGTGAGGCGCGT	0.527													A	73848476	A	A	73848476	3	1	10	1	0	0	0	0	1	0	0	0	8013	1145	40	1	892	1	KCNB2	8	73848476	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	3180655	73848476	72515546	40	692											
COL22A1	169044	broad.mit.edu	37	chr8	139890128	139890128	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtgcctcgcccacgcccaCggcaaagatgcggatgccag	13	15	0	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr8:139890128C>T	uc003yvd.2	-	3	970	c.523G>A	c.(523-525)GTG>ATG	p.V175M		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	175	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCACGCCCACGGCAAAGATG	0.667										HNSCC(7;0.00092)			T	139890128	T	T	139890128	3	4	10	1	0	0	0	0	1	0	0	0	3681	536	19	1	4609	1	COL22A1	8	139890128	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	66041652	139890128	6473894	41	693											
GPR123	84435	broad.mit.edu	37	chr10	134886514	134886514	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaacagtgttatttttacctCcgtcttgcaatcctctcacc	5	13	2	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr10:134886514C>T	uc001llw.2	+	3	548	c.548C>T	c.(547-549)TCC>TTC	p.S183F				Q86SQ6	GP123_HUMAN	RecName: Full=Probable G-protein coupled receptor 123;	Error:Variant_position_missing_in_Q86SQ6_after_alignment						integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		ATTTTTACCTCCGTCTTGCAA	0.562													T	134886514	T	T	134886514	3	4	10	1	0	0	0	0	1	0	0	0	6637	870	30	3		3	GPR123	10	134886514	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08		134886514	648233	42	694											
LRDD	55367	broad.mit.edu	37	chr11	800589	800589	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggccgcaaagaactcttcGccctcgaacatctccaccgt	7	16	2	1	rs151136652		TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:800589G>A	uc001lro.1	-	12	2137	c.1995C>T	c.(1993-1995)GGC>GGT	p.G665G	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Silent_p.G665G|LRDD_uc001lrl.1_Silent_p.G508G|LRDD_uc001lrm.1_Silent_p.G352G|LRDD_uc001lrn.1_Silent_p.G508G|LRDD_uc001lrp.1_Silent_p.G327G	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	665					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGAACTCTTCGCCCTCGAACA	0.682													A	800589	A	A	800589	2	1	10	1	0	0	0	0	0	0	0	1	8936	1074	38	1		1	LRDD	11	800589	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08		800589	134205927	43	695											
OR56A4	120793	broad.mit.edu	37	chr11	6023920	6023920	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttcatgatgaacatctggagGaagcaggctgggaagctgat	14	6	2	3			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:6023920G>A	uc010qzv.1	-	1	459	c.459C>T	c.(457-459)TTC>TTT	p.F153F		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	101	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACATCTGGAGGAAGCAGGCTG	0.532													A	6023920	A	A	6023920	2	1	10	1	0	0	0	0	0	0	0	1	11135	1165	41	3		3	OR56A4	11	6023920	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	5223331	6023920	128982596	44	696											
TRIM3	10612	broad.mit.edu	37	chr11	6470286	6470286	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtagcgataggctttaaagCagtggttgccagcatcagcc	13	9	1	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:6470286C>T	uc001mdh.2	-	13	2594	c.2207G>A	c.(2206-2208)TGC>TAC	p.C736Y	TRIM3_uc001mdi.2_Missense_Mutation_p.C736Y|TRIM3_uc010raj.1_Missense_Mutation_p.C617Y|TRIM3_uc009yfd.2_Missense_Mutation_p.C736Y	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	736	NHL 6.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding	p.C736Y(1)		central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCTTTAAAGCAGTGGTTGCC	0.562													T	6470286	T	T	6470286	3	4	10	1	0	0	0	0	1	0	0	0	16501	710	25	3	31	3	TRIM3	11	6470286	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	446366	6470286	128536230	45	697											
ANO5	203859	broad.mit.edu	37	chr11	22291917	22291917	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaactctgagaagctgtataGtcgatgggagcaggatcatg	13	6	2	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:22291917G>T	uc001mqi.2	+	18	2275	c.1958G>T	c.(1957-1959)AGT>ATT	p.S653I	ANO5_uc001mqj.2_Missense_Mutation_p.S652I	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	653	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						AAGCTGTATAGTCGATGGGAG	0.398													T	22291917	T	T	22291917	3	4	10	1	0	0	0	0	1	0	0	0	700	1029	36	5	2028	5	ANO5	11	22291917	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	15821631	22291917	112714599	46	698											
GAS2	2620	broad.mit.edu	37	chr11	22747846	22747846	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttatttttcagaatctaccGttgaagaagatcccatgcaa	6	8	2	4			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:22747846G>A	uc009yie.2	+	4	582	c.276G>A	c.(274-276)CCG>CCA	p.P92P	GAS2_uc001mqm.2_Silent_p.P92P|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Silent_p.P92P	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	92	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						AGAATCTACCGTTGAAGAAGA	0.393													A	22747846	A	A	22747846	2	1	10	1	0	0	0	0	0	0	0	1	6245	1132	40	1		1	GAS2	11	22747846	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	455929	22747846	112258670	47	699											
RAG1	5896	broad.mit.edu	37	chr11	36596452	36596452	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagaatgtgtcttccagcaCtgatgttggcattattgatg	11	6	1	3			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:36596452C>T	uc001mwu.3	+	2	1722	c.1598C>T	c.(1597-1599)ACT>ATT	p.T533I	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	533					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TCTTCCAGCACTGATGTTGGC	0.493									Familial_Hemophagocytic_Lymphohistiocytosis				T	36596452	T	T	36596452	3	4	10	1	0	0	0	0	1	0	0	0	13003	565	20	3	1600	3	RAG1	11	36596452	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	13848606	36596452	98410064	48	700											
OR4X1	390113	broad.mit.edu	37	chr11	48286015	48286015	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgatcatcaccaatggCggctccatctccgtagtcag	9	14	4	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:48286015C>T	uc010rht.1	+	1	603	c.603C>T	c.(601-603)GGC>GGT	p.G201G		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						TCACCAATGGCGGCTCCATCT	0.557													T	48286015	T	T	48286015	2	4	10	1	0	0	0	0	0	0	0	1	11084	755	27	1		1	OR4X1	11	48286015	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	11689563	48286015	86720501	49	701											
OR5B17	219965	broad.mit.edu	37	chr11	58125932	58125932	+	Frame_Shift_Del	DEL	T	-	-													caagaagtgcaaaaaagacaTtaaaacttgatataagaaca							TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:58125932delT	uc010rke.1	-	1	611	c.611delA	c.(610-612)AATfs	p.N204fs		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AAAAAAGACATTAAAACTTGA	0.368													-	58125932	-	-	58125932	7	5	10	1	0	1	0	1	0	0	0	0	11149	1493	52	0	335	0	OR5B17	11	58125932	Frame_Shift_Del	DEL	T	TCGA-06-0122-01A-01D-1490-08	9839917	58125932	76880584	50	702											
FADS3	3995	broad.mit.edu	37	chr11	61647583	61647583	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaggggctgtaggaacttgCgcacaaaattgagatcttga	12	7	1	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:61647583C>T	uc001nsm.2	-	2	407	c.254G>A	c.(253-255)CGC>CAC	p.R85H	FADS3_uc001nsn.2_5'UTR	NM_021727	NP_068373	Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	85	Cytochrome b5 heme-binding.|Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			ovary(1)|pancreas(1)	2						TAGGAACTTGCGCACAAAATT	0.428													T	61647583	T	T	61647583	3	4	10	1	0	0	0	0	1	0	0	0	5367	768	27	1	1127	1	FADS3	11	61647583	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	3521651	61647583	73358933	51	703											
THRSP	7069	broad.mit.edu	37	chr11	77775138	77775138	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	aggccatctgtgtggatgtgGaccatgggctgctgccgcgg	17	10	1	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:77775138G>C	uc001oyx.2	+	1	232	c.211G>C	c.(211-213)GAC>CAC	p.D71H		NM_003251	NP_003242	Q92748	THRSP_HUMAN	thyroid hormone-responsive protein	71					lipid biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus				breast(1)	1	all_cancers(14;2.23e-19)|all_epithelial(13;7.49e-22)|Breast(9;6.38e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;2.15e-25)			TGTGGATGTGGACCATGGGCT	0.642													C	77775138	C	C	77775138	3	2	10	1	0	0	0	0	1	0	0	0	15873	1174	41	5	213	5	THRSP	11	77775138	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	16127555	77775138	57231378	52	704											
PRCP	5547	broad.mit.edu	37	chr11	82571019	82571019	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttcatgaatctgcacatacCgtgttattacaaaaccagat	5	9	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:82571019C>T	uc001ozs.2	-	2	422	c.309G>A	c.(307-309)ACG>ACA	p.T103T	PRCP_uc001ozr.2_Silent_p.T124T	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	103					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						CTGCACATACCGTGTTATTAC	0.274													T	82571019	T	T	82571019	2	4	10	1	0	0	0	0	0	0	0	1	12449	666	23	2		2	PRCP	11	82571019	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	4795881	82571019	52435497	53	705											
NFRKB	4798	broad.mit.edu	37	chr11	129751720	129751720	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgagggagctggctggcgatGactgccaatccaaaactcgc	13	11	0	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr11:129751720G>C	uc001qfi.2	-	12	1421	c.1220C>G	c.(1219-1221)TCA>TGA	p.S407*	NFRKB_uc001qfg.2_Nonsense_Mutation_p.S432*|NFRKB_uc001qfh.2_Nonsense_Mutation_p.S430*|NFRKB_uc010sbw.1_Nonsense_Mutation_p.S419*	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	407					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GGCTGGCGATGACTGCCAATC	0.557											OREG0021512	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	129751720	C	C	129751720	4	2	10	1	0	0	0	0	0	1	0	0	10384	1294	45	5	2743	5	NFRKB	11	129751720	Nonsense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	47180701	129751720	5254796	54	706											
ESPL1	9700	broad.mit.edu	37	chr12	53684176	53684176	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtttgatgccatccagaagGcacagaaagagaacagcagc	11	9	0	4			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr12:53684176G>A	uc001sck.2	+	24	5378	c.5287G>A	c.(5287-5289)GCA>ACA	p.A1763T	ESPL1_uc001scj.2_Missense_Mutation_p.A1438T	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1763					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CATCCAGAAGGCACAGAAAGA	0.557													A	53684176	A	A	53684176	3	1	10	1	0	0	0	0	1	0	0	0	5253	1203	42	3	5377	3	ESPL1	12	53684176	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08		53684176	80167719	55	707											
LRP1	4035	broad.mit.edu	37	chr12	57598195	57598195	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctccccctggcaccagtgCggacctgccccctggacgag	13	18	0	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr12:57598195C>T	uc001snd.2	+	71	11420	c.10954C>T	c.(10954-10956)CGG>TGG	p.R3652W		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3652	Extracellular (Potential).|LDL-receptor class A 29.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGCACCAGTGCGGACCTGCCC	0.622													T	57598195	T	T	57598195	3	4	10	1	0	0	0	0	1	0	0	0	8951	759	27	1	11236	1	LRP1	12	57598195	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	3914019	57598195	76253700	56	708											
ANO4	121601	broad.mit.edu	37	chr12	101336194	101336194	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aatcaaatggactttactttCgagatggaaagtgtcgaatt	9	5	1	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr12:101336194C>T	uc010svm.1	+	5	909	c.337C>T	c.(337-339)CGA>TGA	p.R113*	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Nonsense_Mutation_p.R78*|ANO4_uc001thx.2_Nonsense_Mutation_p.R113*	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	113	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						ACTTTACTTTCGAGATGGAAA	0.388										HNSCC(74;0.22)			T	101336194	T	T	101336194	4	4	10	1	0	0	0	0	0	1	0	0	699	876	31	2	242	2	ANO4	12	101336194	Nonsense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	43737999	101336194	32515701	57	709											
GCN1L1	10985	broad.mit.edu	37	chr12	120599821	120599821	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctgtgggaggacccggtcCggcgacaggacggaaaggga	19	9	0	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr12:120599821C>T	uc001txo.2	-	21	2218	c.2205G>A	c.(2203-2205)CCG>CCA	p.P735P		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	735					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGACCCGGTCCGGCGACAGGA	0.617													T	120599821	T	T	120599821	2	4	10	1	0	0	0	0	0	0	0	1	6299	639	23	2		2	GCN1L1	12	120599821	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	19263627	120599821	13252074	58	710											
POTEG	404785	broad.mit.edu	37	chr14	19553823	19553823	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagccgaggtaccacgtccGtcgagaagatctggacaagc	14	11	1	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr14:19553823G>A	uc001vuz.1	+	1	459	c.407G>A	c.(406-408)CGT>CAT	p.R136H	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	136								p.R136H(1)		ovary(1)	1						TACCACGTCCGTCGAGAAGAT	0.577													A	19553823	A	A	19553823	3	1	10	1	0	0	0	0	1	0	0	0	12266	1145	40	1	409	1	POTEG	14	19553823	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08		19553823	87795717	59	711											
FOXA1	3169	broad.mit.edu	37	chr14	38061527	38061527	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcttggcgtcgccgccgccGcccgcgcggctgcggcccag	16	19	1	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr14:38061527G>A	uc001wuf.2	-	2	774	c.462C>T	c.(460-462)GGC>GGT	p.G154G	FOXA1_uc010tpz.1_Silent_p.G121G	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	154					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		cgccgccgccgcccgcgcggc	0.567													A	38061527	A	A	38061527	2	1	10	1	0	0	0	0	0	0	0	1	5989	1074	38	1		1	FOXA1	14	38061527	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	18507704	38061527	69288013	60	712											
MDGA2	161357	broad.mit.edu	37	chr14	47426709	47426709	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagtcaaattgacccgtccGtaataatttattgcccaagc	7	10	1	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr14:47426709G>A	uc001wwj.3	-	9	1946	c.1750C>T	c.(1750-1752)CGG>TGG	p.R584W	MDGA2_uc001wwi.3_Missense_Mutation_p.R355W|MDGA2_uc010ani.2_Missense_Mutation_p.R144W	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	584	Ig-like 6.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TGACCCGTCCGTAATAATTTA	0.443													A	47426709	A	A	47426709	3	1	10	1	0	0	0	0	1	0	0	0	9407	1144	40	1	1156	1	MDGA2	14	47426709	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	9365182	47426709	59922831	61	713											
KIAA1409	57578	broad.mit.edu	37	chr14	94173118	94173118	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gtgaaccaccacagcctaagGacgctgccgggctcgggcca	13	15	0	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr14:94173118G>C	uc001ybv.1	+	48	7394	c.7311G>C	c.(7309-7311)AGG>AGC	p.R2437S	KIAA1409_uc001ybs.1_Missense_Mutation_p.R2415S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2592						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		ACAGCCTAAGGACGCTGCCGG	0.567													C	94173118	C	C	94173118	3	2	10	1	0	0	0	0	1	0	0	0	8230	1165	41	5	7431	5	KIAA1409	14	94173118	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	46746409	94173118	13176422	62	714			1	3		2	2	22	G		6.579937e-05
KIAA1409	57578	broad.mit.edu	37	chr14	94173139	94173139	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acgctgccgggctcgggccaGagcagtgctggcctggcagc	17	14	0	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr14:94173139G>C	uc001ybv.1	+	48	7415	c.7332G>C	c.(7330-7332)CAG>CAC	p.Q2444H	KIAA1409_uc001ybs.1_Missense_Mutation_p.Q2422H	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2599						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GCTCGGGCCAGAGCAGTGCTG	0.577													C	94173139	C	C	94173139	3	2	10	1	0	0	0	0	1	0	0	0	8230	933	33	5	7452	5	KIAA1409	14	94173139	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	21	94173139	13176401	63	715			1	3		2	2	22	G		6.579937e-05
BAHD1	22893	broad.mit.edu	37	chr15	40751616	40751616	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccctcacctgcccctgctgaTgggtggacaggcggctctga	13	15	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr15:40751616T>C	uc001zlu.2	+	2	1024	c.953T>C	c.(952-954)ATG>ACG	p.M318T	BAHD1_uc001zlt.2_Missense_Mutation_p.M318T|BAHD1_uc010bbp.1_Missense_Mutation_p.M318T|BAHD1_uc001zlv.2_Missense_Mutation_p.M318T	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	318	Pro-rich.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CCCCTGCTGATGGGTGGACAG	0.652													C	40751616	C	C	40751616	3	2	10	1	0	0	0	0	1	0	0	0	1297	1464	51	4	955	4	BAHD1	15	40751616	Missense_Mutation	SNP	T	TCGA-06-0122-01A-01D-1490-08		40751616	61779776	64	716											
CYP19A1	1588	broad.mit.edu	37	chr15	51507426	51507426	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctcttgtcaggtcaccacGtttctgaacaattggaagat	8	10	4	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr15:51507426G>A	uc001zyz.3	-	9	1113	c.862C>T	c.(862-864)CGT>TGT	p.R288C	CYP19A1_uc001zza.3_Missense_Mutation_p.R288C|CYP19A1_uc001zzb.2_Missense_Mutation_p.R288C	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	288					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	AGGTCACCACGTTTCTGAACA	0.403													A	51507426	A	A	51507426	3	1	10	1	0	0	0	0	1	0	0	0	4148	1145	40	1	661	1	CYP19A1	15	51507426	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	10755810	51507426	51023966	65	717											
CILP	8483	broad.mit.edu	37	chr15	65490345	65490345	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggcaagaacctctcactcCggtaggccctcaccttaaca	7	15	2	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr15:65490345C>T	uc002aon.2	-	9	2460	c.2279G>A	c.(2278-2280)CGG>CAG	p.R760Q		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	760					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CCTCTCACTCCGGTAGGCCCT	0.547													T	65490345	T	T	65490345	3	4	10	1	0	0	0	0	1	0	0	0	3429	652	23	2	1279	2	CILP	15	65490345	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	13982919	65490345	37041047	66	718											
BTBD12	84464	broad.mit.edu	37	chr16	3642834	3642834	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacgctgggtcagaaccccGtcctctacagcggagaagcc	11	15	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr16:3642834G>A	uc002cvp.2	-	11	2820	c.2193C>T	c.(2191-2193)GAC>GAT	p.D731D		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	731	BTB.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						TCAGAACCCCGTCCTCTACAG	0.567								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				A	3642834	A	A	3642834	2	1	10	1	0	0	0	0	0	0	0	1	1540	1136	40	1		1	BTBD12	16	3642834	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08		3642834	86711919	67	719											
ANKRD11	29123	broad.mit.edu	37	chr16	89351279	89351279	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaactgacctctgaccaagcCggggaagaaatggttttcca	11	10	1	3			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr16:89351279C>T	uc002fmx.1	-	9	2132	c.1671G>A	c.(1669-1671)CCG>CCA	p.P557P	ANKRD11_uc002fmy.1_Silent_p.P557P|ANKRD11_uc002fnc.1_Silent_p.P557P|ANKRD11_uc002fnb.1_Silent_p.P514P	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	557	Ser-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTGACCAAGCCGGGGAAGAAA	0.562													T	89351279	T	T	89351279	2	4	10	1	0	0	0	0	0	0	0	1	639	639	23	2		2	ANKRD11	16	89351279	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	85708445	89351279	1003474	68	720											
COX10	1352	broad.mit.edu	37	chr17	14110273	14110273	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgccggcgcgtggcgctgCgccactgcctggccctgctc	15	17	0	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr17:14110273C>T	uc002gof.3	+	7	1279	c.1075C>T	c.(1075-1077)CGC>TGC	p.R359C	COX10_uc010vvs.1_Missense_Mutation_p.R142C|COX10_uc010vvt.1_Missense_Mutation_p.R167C	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	359					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		CGTGGCGCTGCGCCACTGCCT	0.657													T	14110273	T	T	14110273	3	4	10	1	0	0	0	0	1	0	0	0	3762	768	27	1	1101	1	COX10	17	14110273	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08		14110273	67084937	69	721											
SYNRG	11276	broad.mit.edu	37	chr17	35928904	35928904	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cttttctacctgtttccatgCtgggagttacttgtttttga	8	8	1	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr17:35928904C>G	uc002hoa.2	-	11	1553	c.1470G>C	c.(1468-1470)CAG>CAC	p.Q490H	SYNRG_uc010wde.1_Missense_Mutation_p.Q412H|SYNRG_uc010wdf.1_Missense_Mutation_p.Q412H|SYNRG_uc002hoc.2_Missense_Mutation_p.Q411H|SYNRG_uc002hoe.2_Missense_Mutation_p.Q412H|SYNRG_uc002hod.2_Missense_Mutation_p.Q412H|SYNRG_uc010wdg.1_Missense_Mutation_p.Q329H|SYNRG_uc002hob.2_Missense_Mutation_p.Q490H|SYNRG_uc002hof.2_Missense_Mutation_p.Q202H|SYNRG_uc010cvd.1_Missense_Mutation_p.Q290H|SYNRG_uc002hog.1_Missense_Mutation_p.Q624H	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	490					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						TGTTTCCATGCTGGGAGTTAC	0.363													G	35928904	G	G	35928904	3	3	10	1	0	0	0	0	1	0	0	0	15457	796	28	5	2595	5	SYNRG	17	35928904	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	21818631	35928904	45266306	70	722											
KRT34	3885	broad.mit.edu	37	chr17	39535345	39535345	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgccagctgagactccacGttggtgatcaggctctgcac	11	13	3	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr17:39535345G>A	uc002hwm.2	-	6	1098	c.1086C>T	c.(1084-1086)AAC>AAT	p.N362N		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	362	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				GAGACTCCACGTTGGTGATCA	0.617													A	39535345	A	A	39535345	2	1	10	1	0	0	0	0	0	0	0	1	8471	1136	40	1		1	KRT34	17	39535345	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	3606441	39535345	41659865	71	723											
ARMC7	79637	broad.mit.edu	37	chr17	73125017	73125017	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggctccggaacctggcaCagatcttcctggaggacttc	11	14	1	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr17:73125017C>T	uc002jmw.1	+	3	783	c.481C>T	c.(481-483)CAG>TAG	p.Q161*	ARMC7_uc010wru.1_3'UTR|ARMC7_uc010dga.1_RNA	NM_024585	NP_078861	Q9H6L4	ARMC7_HUMAN	armadillo repeat containing 7	161							binding			pancreas(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)			GAACCTGGCACAGATCTTCCT	0.706													T	73125017	T	T	73125017	4	4	10	1	0	0	0	0	0	1	0	0	956	479	17	3	491	3	ARMC7	17	73125017	Nonsense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	33589672	73125017	8070193	72	724											
ANKRD12	23253	broad.mit.edu	37	chr18	9280962	9280962	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttttaatgaggcaacaAcatgaagctgcggctttaaa	9	7	1	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr18:9280962A>C	uc002knv.2	+	13	6284	c.6027A>C	c.(6025-6027)CAA>CAC	p.Q2009H	ANKRD12_uc002knw.2_Missense_Mutation_p.Q1986H|ANKRD12_uc002knx.2_Missense_Mutation_p.Q1986H	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	2009						nucleus				ovary(2)|central_nervous_system(1)	3						TGAGGCAACAACATGAAGCTG	0.363													C	9280962	C	C	9280962	3	2	10	1	0	0	0	0	1	0	0	0	640	40	2	5	6073	5	ANKRD12	18	9280962	Missense_Mutation	SNP	A	TCGA-06-0122-01A-01D-1490-08		9280962	68796286	73	725											
GALR1	2587	broad.mit.edu	37	chr18	74962646	74962646	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctgatcttcgcgctgggtGtgctgggcaacagcctagtg	15	11	1	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr18:74962646G>A	uc002lms.3	+	1	639	c.142G>A	c.(142-144)GTG>ATG	p.V48M		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	48	Helical; Name=1; (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		CGCGCTGGGTGTGCTGGGCAA	0.682													A	74962646	A	A	74962646	3	1	10	1	0	0	0	0	1	0	0	0	6227	1377	48	3	144	3	GALR1	18	74962646	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	65681684	74962646	3114602	74	726											
OR7G2	390882	broad.mit.edu	37	chr19	9213120	9213120	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ccactgcagtcttcctaggtGagtcagtaaccacagaacta	8	12	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr19:9213120G>C	uc010xkk.1	-	1	863	c.863C>G	c.(862-864)TCA>TGA	p.S288*		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTTCCTAGGTGAGTCAGTAAC	0.463													C	9213120	C	C	9213120	4	2	10	1	0	0	0	0	0	1	0	0	11223	1294	45	5	176	5	OR7G2	19	9213120	Nonsense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08		9213120	49915863	75	727											
C19orf44	84167	broad.mit.edu	37	chr19	16612069	16612069	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacttcccagaatcaagccCgtgaacttcctgtcaccgaa	6	14	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr19:16612069C>T	uc002neh.1	+	2	539	c.466C>T	c.(466-468)CGT>TGT	p.R156C	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.R156C|C19orf44_uc002neg.2_Missense_Mutation_p.R156C|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	156											0						GAATCAAGCCCGTGAACTTCC	0.498													T	16612069	T	T	16612069	3	4	10	1	0	0	0	0	1	0	0	0	1927	652	23	2	468	2	C19orf44	19	16612069	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	7398949	16612069	42516914	76	728											
KLHL26	55295	broad.mit.edu	37	chr19	18779533	18779533	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcgcaatgagtggggctaCgcctgctcgctgaagcgccg	16	13	0	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr19:18779533C>T	uc002njz.1	+	3	1353	c.1326C>T	c.(1324-1326)TAC>TAT	p.Y442Y		NM_018316	NP_060786	Q53HC5	KLH26_HUMAN	kelch-like 26	442	Kelch 3.									ovary(1)	1						AGTGGGGCTACGCCTGCTCGC	0.701													T	18779533	T	T	18779533	2	4	10	1	0	0	0	0	0	0	0	1	8381	547	19	1		1	KLHL26	19	18779533	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	2167464	18779533	40349450	77	729											
APLP1	333	broad.mit.edu	37	chr19	36363501	36363501	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctggaggagcgtaggatgCgccagattaatgaggtgata	15	6	0	3			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr19:36363501C>T	uc002oce.2	+	7	1105	c.967C>T	c.(967-969)CGC>TGC	p.R323C	APLP1_uc010xsz.1_Missense_Mutation_p.R284C|APLP1_uc002ocf.2_Missense_Mutation_p.R323C|APLP1_uc002ocg.2_Missense_Mutation_p.R226C|APLP1_uc010xta.1_Missense_Mutation_p.R317C	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	323	Heparin-binding (By similarity).|Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCGTAGGATGCGCCAGATTAA	0.537													T	36363501	T	T	36363501	3	4	10	1	0	0	0	0	1	0	0	0	778	768	27	1	993	1	APLP1	19	36363501	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	17583968	36363501	22765482	78	730											
PSG8	440533	broad.mit.edu	37	chr19	43269670	43269670	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccaggaggttctctcctcacCtgtgagcaggagccccttcc	10	16	2	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr19:43269670C>A	uc002ouo.2	-	1	162	c.64G>T	c.(64-66)GCA>TCA	p.A22S	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_5'UTR|PSG8_uc002ouh.2_Missense_Mutation_p.A22S|PSG8_uc010ein.2_Missense_Mutation_p.V22L|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Intron|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	22						extracellular region					0		Prostate(69;0.00899)				CTCTCCTCACCTGTGAGCAGG	0.552													A	43269670	A	A	43269670	3	1	10	1	0	0	0	0	1	0	0	0	12661	695	24	5	1257	5	PSG8	19	43269670	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	6906169	43269670	15859313	79	731											
ZNF229	7772	broad.mit.edu	37	chr19	44933156	44933156	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcccacacacgtcacacacGtagggcctctctcccgtgtg	8	17	2	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr19:44933156G>A	uc002oze.1	-	6	2234	c.1800C>T	c.(1798-1800)TAC>TAT	p.Y600Y	ZNF229_uc010ejk.1_Silent_p.Y254Y|ZNF229_uc010ejl.1_Silent_p.Y594Y	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	600	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				CGTCACACACGTAGGGCCTCT	0.542													A	44933156	A	A	44933156	2	1	10	1	0	0	0	0	0	0	0	1	17779	1140	40	1		1	ZNF229	19	44933156	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	1663486	44933156	14195827	80	732											
SPIB	6689	broad.mit.edu	37	chr19	50926144	50926144	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctatgaagccttcgacccGgcagcagccgcttttagcca	9	16	0	1			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr19:50926144G>A	uc002psd.2	+	4	214	c.189G>A	c.(187-189)CCG>CCA	p.P63P	SPIB_uc002pse.2_Silent_p.P63P|SPIB_uc010ycc.1_Intron	NM_003121	NP_003112	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	63					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			lung(1)|kidney(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CCTTCGACCCGGCAGCAGCCG	0.662													A	50926144	A	A	50926144	2	1	10	1	0	0	0	0	0	0	0	1	15049	1103	39	2		2	SPIB	19	50926144	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	5992988	50926144	8202839	81	733											
SIGLEC9	27180	broad.mit.edu	37	chr19	51630497	51630497	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatgcagctgaattcacctGcagagctcagaaccctctcg	10	13	3	3			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr19:51630497G>A	uc002pvu.2	+	4	1026	c.959G>A	c.(958-960)TGC>TAC	p.C320Y	SIGLEC9_uc010yct.1_Missense_Mutation_p.C320Y	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	320	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		GAATTCACCTGCAGAGCTCAG	0.622													A	51630497	A	A	51630497	3	1	10	1	0	0	0	0	1	0	0	0	14315	1319	46	3	973	3	SIGLEC9	19	51630497	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	704353	51630497	7498486	82	734											
ZNF417	147687	broad.mit.edu	37	chr19	58423432	58423432	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgtgagcaacttacccagCgaggatatgagagccaggtt	13	9	0	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr19:58423432C>T	uc002qqq.2	-	2	358	c.159G>A	c.(157-159)TCG>TCA	p.S53S	ZNF417_uc010yhm.1_Silent_p.S10S|ZNF417_uc002qqr.2_Silent_p.S52S	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	53	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		ACTTACCCAGCGAGGATATGA	0.498													T	58423432	T	T	58423432	2	4	10	1	0	0	0	0	0	0	0	1	17891	755	27	1		1	ZNF417	19	58423432	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	6792935	58423432	705551	83	735											
XKR7	343702	broad.mit.edu	37	chr20	30584453	30584453	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcacctgttcagcattgcCgcccgcggcctggccttcgc	12	17	1	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr20:30584453C>T	uc002wxe.2	+	3	1107	c.933C>T	c.(931-933)GCC>GCT	p.A311A		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	311						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TCAGCATTGCCGCCCGCGGCC	0.637													T	30584453	T	T	30584453	2	4	10	1	0	0	0	0	0	0	0	1	17433	639	23	2		2	XKR7	20	30584453	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08		30584453	32441067	84	736											
KIAA1755	85449	broad.mit.edu	37	chr20	36869819	36869819	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tacttgctcccatatgtcctGcccttacccttggccaaact	5	16	0	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr20:36869819G>C	uc002xhy.1	-	3	986	c.714C>G	c.(712-714)GGC>GGG	p.G238G	KIAA1755_uc002xhz.1_Silent_p.G238G	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	238										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				CATATGTCCTGCCCTTACCCT	0.582													C	36869819	C	C	36869819	2	2	10	1	0	0	0	0	0	0	0	1	8257	1306	46	5		5	KIAA1755	20	36869819	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	6285366	36869819	26155701	85	737											
TOX2	84969	broad.mit.edu	37	chr20	42695486	42695486	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cccagtggggagtgtggcatCagcacctgcaggttagtcct	14	11	1	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr20:42695486C>G	uc002xlf.3	+	7	1436	c.1419C>G	c.(1417-1419)ATC>ATG	p.I473M	TOX2_uc010ggo.2_Missense_Mutation_p.I491M|TOX2_uc002xle.3_Missense_Mutation_p.I449M|TOX2_uc010ggp.2_Missense_Mutation_p.I449M|TOX2_uc002xlg.2_Missense_Mutation_p.I290M|TOX2_uc010zwk.1_Missense_Mutation_p.I369M	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	473					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGTGTGGCATCAGCACCTGCA	0.647													G	42695486	G	G	42695486	3	3	10	1	0	0	0	0	1	0	0	0	16375	816	29	5	1633	5	TOX2	20	42695486	Missense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	5825667	42695486	20330034	86	738											
ZSWIM3	140831	broad.mit.edu	37	chr20	44506781	44506781	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cacctggtggacatggctggCtcttcagtggacgttcagct	13	11	3	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr20:44506781C>G	uc002xqd.2	+	2	1787	c.1584C>G	c.(1582-1584)GGC>GGG	p.G528G	ZSWIM3_uc010zxg.1_Silent_p.G522G	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	528							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				ACATGGCTGGCTCTTCAGTGG	0.547													G	44506781	G	G	44506781	2	3	10	1	0	0	0	0	0	0	0	1	18239	784	28	5		5	ZSWIM3	20	44506781	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	1811295	44506781	18518739	87	739											
TSHZ2	128553	broad.mit.edu	37	chr20	51871857	51871857	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgggaaagaaagtccccaCgaagaggcctcatctttcag	11	10	3	2	rs143642849		TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr20:51871857C>T	uc002xwo.2	+	2	2816	c.1860C>T	c.(1858-1860)CAC>CAT	p.H620H		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	620					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AAAGTCCCCACGAAGAGGCCT	0.517													T	51871857	T	T	51871857	2	4	10	1	0	0	0	0	0	0	0	1	16621	535	19	1		1	TSHZ2	20	51871857	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	7365076	51871857	11153663	88	740											
TIMP3	7078	broad.mit.edu	37	chr22	33255261	33255261	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttcggttaccctggctaccAgtccaaacactacgcctgca	7	15	0	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr22:33255261A>C	uc003anb.2	+	5	1719	c.533A>C	c.(532-534)CAG>CCG	p.Q178P	SYN3_uc003amx.2_Intron|SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Intron	NM_000362	NP_000353	P35625	TIMP3_HUMAN	tissue inhibitor of metalloproteinase 3	178	Mediates interaction with EFEMP1.				negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			lung(1)	1						CCTGGCTACCAGTCCAAACAC	0.557													C	33255261	C	C	33255261	3	2	10	1	0	0	0	0	1	0	0	0	15916	188	7	5	551	5	TIMP3	22	33255261	Missense_Mutation	SNP	A	TCGA-06-0122-01A-01D-1490-08		33255261	18049305	89	741											
NHP2L1	4809	broad.mit.edu	37	chr22	42071074	42071074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccagggcctgcttggagcGcacaaacacgtagggcacat	12	14	0	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chr22:42071074G>A	uc003bat.2	-	3	444	c.250C>T	c.(250-252)CGC>TGC	p.R84C	NHP2L1_uc003bau.2_Missense_Mutation_p.R84C|NHP2L1_uc003bav.2_Missense_Mutation_p.R84C|NHP2L1_uc003baw.2_Missense_Mutation_p.R84C	NM_005008	NP_004999	P55769	NH2L1_HUMAN	NHP2 non-histone chromosome protein 2-like 1	84					nuclear mRNA splicing, via spliceosome|ribosome biogenesis	box C/D snoRNP complex|nucleoplasm|spliceosomal complex	protein binding|RNA binding				0						TGCTTGGAGCGCACAAACACG	0.577													A	42071074	A	A	42071074	3	1	10	1	0	0	0	0	1	0	0	0	10410	1087	38	1	140	1	NHP2L1	22	42071074	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08	8815813	42071074	9233492	90	742											
PRPS2	5634	broad.mit.edu	37	chrX	12817486	12817486	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatcccgtgtttcccatacGcccgacaagataaaaaggac	8	12	0	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chrX:12817486G>A	uc004cvb.2	+	2	407	c.283G>A	c.(283-285)GCC>ACC	p.A95T	PRPS2_uc004cva.2_Missense_Mutation_p.A95T|PRPS2_uc010nec.2_Missense_Mutation_p.A28T	NM_002765	NP_002756	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	95					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity				0						TTTCCCATACGCCCGACAAGA	0.468													A	12817486	A	A	12817486	3	1	10	1	0	0	0	0	1	0	0	0	12580	1087	38	1	289	1	PRPS2	23	12817486	Missense_Mutation	SNP	G	TCGA-06-0122-01A-01D-1490-08		12817486	142453074	91	743											
PPP1R3F	89801	broad.mit.edu	37	chrX	49142412	49142412	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gccatcaggattcccccctcCtcccctctctgtggcctggg	9	19	2	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chrX:49142412C>G	uc004dnh.1	+	4	1276	c.1260C>G	c.(1258-1260)TCC>TCG	p.S420S	PPP1R3F_uc011mnd.1_Silent_p.S91S|PPP1R3F_uc004dni.2_Silent_p.S74S|PPP1R3F_uc004dnj.1_Silent_p.S74S	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	420	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)					TTCCCCCCTCCTCCCCTCTCT	0.662													G	49142412	G	G	49142412	2	3	10	1	0	0	0	0	0	0	0	1	12375	668	24	5		5	PPP1R3F	23	49142412	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	36324926	49142412	106128148	92	744											
AWAT2	158835	broad.mit.edu	37	chrX	69262197	69262197	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaatgtgctgatcatagagGtccgtctccccaaaggcata	9	10	2	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chrX:69262197G>A	uc004dxt.1	-	6	693	c.687C>T	c.(685-687)GAC>GAT	p.D229D		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	229						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0						GATCATAGAGGTCCGTCTCCC	0.502													A	69262197	A	A	69262197	2	1	10	1	0	0	0	0	0	0	0	1	1235	1252	44	3		3	AWAT2	23	69262197	Silent	SNP	G	TCGA-06-0122-01A-01D-1490-08	20119785	69262197	86008363	93	745											
KLHL4	56062	broad.mit.edu	37	chrX	86873003	86873003	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cttgtcttctgcagctgactCaggtcattgatgtttgctcc	9	11	4	2			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chrX:86873003C>T	uc004efb.2	+	4	978	c.796C>T	c.(796-798)CAG>TAG	p.Q266*	KLHL4_uc004efa.2_Nonsense_Mutation_p.Q266*	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	266						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCAGCTGACTCAGGTCATTGA	0.418													T	86873003	T	T	86873003	4	4	10	1	0	0	0	0	0	1	0	0	8391	827	29	3	810	3	KLHL4	23	86873003	Nonsense_Mutation	SNP	C	TCGA-06-0122-01A-01D-1490-08	17610806	86873003	68397557	94	746											
MCART6	401612	broad.mit.edu	37	chrX	103349047	103349047	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcagctctttcctggagtgCgacttcctctgcaggaagtc	10	12	3	0	rs138837474		TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chrX:103349047C>T	uc004elu.2	-	2	1075	c.894G>A	c.(892-894)TCG>TCA	p.S298S		NM_001012755	NP_001012773	Q5H9E4	MCAR6_HUMAN	mitochondrial carrier triple repeat 6	298	Solcar 3.				transport	integral to membrane|mitochondrial inner membrane					0						TCCTGGAGTGCGACTTCCTCT	0.502													T	103349047	T	T	103349047	2	4	10	1	0	0	0	0	0	0	0	1	9371	755	27	1		1	MCART6	23	103349047	Silent	SNP	C	TCGA-06-0122-01A-01D-1490-08	16476044	103349047	51921513	95	747											
KLHL13	90293	broad.mit.edu	37	chrX	117033178	117033178	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aatagtattcacagcttaggAcatcatcataatcacttgtt	5	8	4	0			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chrX:117033178A>T	uc004eql.2	-	7	1723	c.1661T>A	c.(1660-1662)GTC>GAC	p.V554D	KLHL13_uc004eqk.2_Missense_Mutation_p.V503D|KLHL13_uc011mtn.1_Missense_Mutation_p.V394D|KLHL13_uc011mto.1_Missense_Mutation_p.V548D|KLHL13_uc011mtp.1_Missense_Mutation_p.V556D|KLHL13_uc004eqm.2_Missense_Mutation_p.V503D|KLHL13_uc011mtq.1_Missense_Mutation_p.V538D	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	554	Kelch 5.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						ACAGCTTAGGACATCATCATA	0.463													T	117033178	T	T	117033178	3	4	10	1	0	0	0	0	1	0	0	0	8369	275	10	5	310	5	KLHL13	23	117033178	Missense_Mutation	SNP	A	TCGA-06-0122-01A-01D-1490-08	13684131	117033178	38237382	96	748											
THOC2	57187	broad.mit.edu	37	chrX	122820484	122820484	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agattctaacaaagatataaAgaagtcatcgtgttctggcc	8	7	3	3			TCGA-06-0122-01A-01D-1490-08	TCGA-06-0122-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	08c54819-32fa-455d-a443-fc71dfd3f03a	292c6490-aa26-452e-aeba-0a65c2f125c7	g.chrX:122820484A>G	uc004etu.2	-	8	714	c.682T>C	c.(682-684)TTT>CTT	p.F228L	THOC2_uc011muh.1_Missense_Mutation_p.F149L|THOC2_uc011mui.1_Missense_Mutation_p.F113L	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	228					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						AAAGATATAAAGAAGTCATCG	0.368													G	122820484	G	G	122820484	3	3	10	1	0	0	0	0	1	0	0	0	15862	72	3	4	4223	4	THOC2	23	122820484	Missense_Mutation	SNP	A	TCGA-06-0122-01A-01D-1490-08	5787306	122820484	32450076	97	749											
CPSF3L	54973	broad.mit.edu	37	chr1	1248063	1248063	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccgtctcgccattggccgGcatgtagcagttgacccctg	11	15	1	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr1:1248063G>A	uc001aee.1	-	13	1370	c.1312C>T	c.(1312-1314)CCG>TCG	p.P438S	CPSF3L_uc009vjy.1_RNA|CPSF3L_uc001aef.1_Missense_Mutation_p.P444S|CPSF3L_uc009vjz.1_Missense_Mutation_p.P416S|CPSF3L_uc010nyj.1_Missense_Mutation_p.P409S|CPSF3L_uc001aeg.1_Missense_Mutation_p.P314S|CPSF3L_uc001aeh.1_Missense_Mutation_p.P337S|CPSF3L_uc001aei.1_Missense_Mutation_p.P340S|CPSF3L_uc001aej.1_Missense_Mutation_p.P265S|CPSF3L_uc001aek.1_Missense_Mutation_p.P180S	NM_017871	NP_060341	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor	438						Golgi apparatus|nucleus	hydrolase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		CCATTGGCCGGCATGTAGCAG	0.716													A	1248063	A	A	1248063	3	1	11	1	0	0	0	0	1	0	0	0	3827	1203	42	3	510	3	CPSF3L	1	1248063	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		1248063	248002558	1	750											
KIF17	57576	broad.mit.edu	37	chr1	21014370	21014370	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaagcaggcgggtactcagcGctgctggcaaactcagccct	12	13	2	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr1:21014370G>A	uc001bdr.3	-	8	1567	c.1449C>T	c.(1447-1449)AGC>AGT	p.S483S	KIF17_uc001bdp.3_5'Flank|KIF17_uc001bdq.3_5'Flank|KIF17_uc009vpx.2_Intron|KIF17_uc001bds.3_Silent_p.S483S	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	483					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GGTACTCAGCGCTGCTGGCAA	0.532													A	21014370	A	A	21014370	2	1	11	1	0	0	0	0	0	0	0	1	8279	1078	38	1		1	KIF17	1	21014370	Silent	SNP	G	TCGA-06-0124-01A-01D-1490-08	19766307	21014370	228236251	2	751											
FOXJ3	22887	broad.mit.edu	37	chr1	42744223	42744223	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gggtcaaggagtgcattcttCttagaaattcctgttccatg	10	8	3	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr1:42744223C>T	uc001che.2	-	5	477	c.165G>A	c.(163-165)AAG>AAA	p.K55K	FOXJ3_uc001chf.2_Silent_p.K55K|FOXJ3_uc001chg.2_Silent_p.K55K|FOXJ3_uc001chh.1_Silent_p.K55K	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	55					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTGCATTCTTCTTAGAAATTC	0.453													T	42744223	T	T	42744223	2	4	11	1	0	0	0	0	0	0	0	1	6013	912	32	3		3	FOXJ3	1	42744223	Silent	SNP	C	TCGA-06-0124-01A-01D-1490-08	21729853	42744223	206506398	3	752											
VCAM1	7412	broad.mit.edu	37	chr1	101197065	101197066	+	Frame_Shift_Del	DEL	TA	-	-													ggcagagtacgcaaacacttTatgtcaatggtaagtacata							TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr1:101197065_101197066delTA	uc001dti.2	+	6	1636_1637	c.1516_1517delTA	c.(1516-1518)TATfs	p.Y506fs	VCAM1_uc001dtj.2_Frame_Shift_Del_p.Y414fs|VCAM1_uc010ouj.1_Frame_Shift_Del_p.Y444fs	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	506	Ig-like C2-type 5.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GCAAACACTTTATGTCAATGGT	0.366													-	101197066	-	-	101197065	7	5	11	1	0	1	0	1	0	0	0	0	17134	1754	61	0	1538	0	VCAM1	1	101197065	Frame_Shift_Del	DEL	TA	TCGA-06-0124-01A-01D-1490-08	58452842	101197065	148053556	4	753											
IGSF3	3321	broad.mit.edu	37	chr1	117159063	117159063	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgaacggtgacctgccgCtgtgctgacaccacacctac	9	16	0	3			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr1:117159063C>T	uc001egr.1	-	3	765	c.60G>A	c.(58-60)CAG>CAA	p.Q20Q	IGSF3_uc001egq.1_Silent_p.Q20Q	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	20	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		TGACCTGCCGCTGTGCTGACA	0.527													T	117159063	T	T	117159063	2	4	11	1	0	0	0	0	0	0	0	1	7601	796	28	3		3	IGSF3	1	117159063	Silent	SNP	C	TCGA-06-0124-01A-01D-1490-08	15961998	117159063	132091558	5	754											
FLG	2312	broad.mit.edu	37	chr1	152275657	152275657	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tatcgcggtgagaggatccgGggtgtctggagccatctctt	15	9	2	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr1:152275657G>T	uc001ezu.1	-	3	11741	c.11705C>A	c.(11704-11706)CCC>CAC	p.P3902H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3902	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGAGGATCCGGGGTGTCTGGA	0.512									Ichthyosis				T	152275657	T	T	152275657	3	4	11	1	0	0	0	0	1	0	0	0	5922	1232	43	5	484	5	FLG	1	152275657	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	35116594	152275657	96974964	6	755											
SELE	6401	broad.mit.edu	37	chr1	169698774	169698774	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggttttggaaacattccacGaacccattggctggatttgt	11	8	0	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr1:169698774G>A	uc001ggm.3	-	6	913	c.756C>T	c.(754-756)TTC>TTT	p.F252F	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	252	Sushi 2.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					AACATTCCACGAACCCATTGG	0.428													A	169698774	A	A	169698774	2	1	11	1	0	0	0	0	0	0	0	1	14013	1049	37	2		2	SELE	1	169698774	Silent	SNP	G	TCGA-06-0124-01A-01D-1490-08	17423117	169698774	79551847	7	756											
APOB	338	broad.mit.edu	37	chr2	21239331	21239331	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttaggtggcccatgagggcGacctcagtaattttcttgtt	11	9	2	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr2:21239331G>A	uc002red.2	-	21	3440	c.3312C>T	c.(3310-3312)GTC>GTT	p.V1104V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1104					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCATGAGGGCGACCTCAGTAA	0.478													A	21239331	A	A	21239331	2	1	11	1	0	0	0	0	0	0	0	1	785	1045	37	2		2	APOB	2	21239331	Silent	SNP	G	TCGA-06-0124-01A-01D-1490-08		21239331	221960042	8	757											
CD207	50489	broad.mit.edu	37	chr2	71058942	71058942	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agtccccccgctgttttataCagaaactcctgtaggaaaga	8	11	0	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr2:71058942C>G	uc002shg.2	-	5	773	c.726G>C	c.(724-726)CTG>CTC	p.L242L		NM_015717	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 antigen, langerin	242	C-type lectin.|Extracellular (Potential).				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			ovary(1)|lung(1)	2						CTGTTTTATACAGAAACTCCT	0.537													G	71058942	G	G	71058942	2	3	11	1	0	0	0	0	0	0	0	1	2983	465	17	5		5	CD207	2	71058942	Silent	SNP	C	TCGA-06-0124-01A-01D-1490-08	49819611	71058942	172140431	9	758											
ZAP70	7535	broad.mit.edu	37	chr2	98351172	98351172	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagggcgtgtaccgcatgcGcaagtatggccgcccctgcc	13	16	0	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr2:98351172G>A	uc002syd.1	+	9	1286	c.1079G>A	c.(1078-1080)CGC>CAC	p.R360H	ZAP70_uc010yvf.1_3'UTR|ZAP70_uc002sye.1_Missense_Mutation_p.R250H|ZAP70_uc002syf.1_Missense_Mutation_p.R53H	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	360	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						TACCGCATGCGCAAGTATGGC	0.637													A	98351172	A	A	98351172	3	1	11	1	0	0	0	0	1	0	0	0	17511	1087	38	1	1105	1	ZAP70	2	98351172	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	27292230	98351172	144848201	10	759											
MYO7B	4648	broad.mit.edu	37	chr2	128342397	128342399	+	In_Frame_Del	DEL	CAA	-	-													aagctgaacagcgtccatgcCaacaacaaggccttcctaca							TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr2:128342397_128342399delCAA	uc002top.2	+	14	1652_1654	c.1599_1601delCAA	c.(1597-1602)GCCAAC>GCC	p.N535del		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	535	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GCGTCCATGCCAACAACAAGGCC	0.571													-	128342399	-	-	128342397	7	5	11	1	0	1	0	1	0	0	0	0	10083	581	21	0	1649	0	MYO7B	2	128342397	In_Frame_Del	DEL	CAA	TCGA-06-0124-01A-01D-1490-08	29991225	128342397	114856976	11	760											
MORC1	27136	broad.mit.edu	37	chr3	108754309	108754309	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgcaaaacaatgttaaatttCtattatcttttaaaaaaaaa	2	4	2	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr3:108754309C>T	uc003dxl.2	-	15	1424	c.1337G>A	c.(1336-1338)AGA>AAA	p.R446K	MORC1_uc011bhn.1_Missense_Mutation_p.R446K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	446					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TGTTAAATTTCTATTATCTTT	0.254													T	108754309	T	T	108754309	3	4	11	1	0	0	0	0	1	0	0	0	9701	913	32	3	1673	3	MORC1	3	108754309	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08		108754309	89268121	12	761											
BOD1L	259282	broad.mit.edu	37	chr4	13606401	13606401	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttttcaaatgtggtgtttcaGaatcatctttctttagatgc	7	6	5	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr4:13606401G>C	uc003gmz.1	-	10	2240	c.2123C>G	c.(2122-2124)TCT>TGT	p.S708C	BOD1L_uc010idr.1_Missense_Mutation_p.S45C	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	708	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						TGGTGTTTCAGAATCATCTTT	0.398													C	13606401	C	C	13606401	3	2	11	1	0	0	0	0	1	0	0	0	1483	942	33	5	7100	5	BOD1L	4	13606401	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		13606401	177547875	13	762											
SEPSECS	51091	broad.mit.edu	37	chr4	25125641	25125641	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccacatcttcagttttgtcaTaattgtcatcactctcttta	3	11	6	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr4:25125641T>C	uc003grg.2	-	11	1631	c.1418A>G	c.(1417-1419)TAT>TGT	p.Y473C	SEPSECS_uc003gri.2_Missense_Mutation_p.Y472C|SEPSECS_uc003grh.2_Missense_Mutation_p.Y394C	NM_153825	NP_722547	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine)	473					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding				0		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	AGTTTTGTCATAATTGTCATC	0.378													C	25125641	C	C	25125641	3	2	11	1	0	0	0	0	1	0	0	0	14058	1406	49	4	91	4	SEPSECS	4	25125641	Missense_Mutation	SNP	T	TCGA-06-0124-01A-01D-1490-08	11519240	25125641	166028635	14	763											
SLC34A2	10568	broad.mit.edu	37	chr4	25664233	25664236	+	Splice_Site	DEL	AAGT	-	-													aaaagcaaagagaccaacaaAagtaagtgtcgctcgtttgt							TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr4:25664233_25664236delAAGT	uc003grr.2	+	2	193	c.112_splice	c.e2+1	p.T38_splice	SLC34A2_uc003grs.2_Splice_Site_p.N38_splice|SLC34A2_uc010iev.2_Splice_Site_p.N38_splice	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),						cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				AGACCAACAAAAGTAAGTGTCGCT	0.534													-	25664236	-	-	25664233	8	5	11	1	0	1	0	1	0	0	1	0	14568	28	1	0	113	0	SLC34A2	4	25664233	Splice_Site	DEL	AAGT	TCGA-06-0124-01A-01D-1490-08	538592	25664233	165490043	15	764											
RBM47	54502	broad.mit.edu	37	chr4	40440818	40440818	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgccagcagtgctgcctcGttgggcgcgcccgccacgcc	14	18	0	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr4:40440818G>A	uc003gvc.2	-	4	803	c.93C>T	c.(91-93)AAC>AAT	p.N31N	RBM47_uc003gvd.2_Silent_p.N31N|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Intron|RBM47_uc003gvg.1_Silent_p.N31N	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	31						nucleus	nucleotide binding|RNA binding			breast(3)	3						GTGCTGCCTCGTTGGGCGCGC	0.697													A	40440818	A	A	40440818	2	1	11	1	0	0	0	0	0	0	0	1	13141	1136	40	1		1	RBM47	4	40440818	Silent	SNP	G	TCGA-06-0124-01A-01D-1490-08	14776585	40440818	150713458	16	765											
ADAM29	11086	broad.mit.edu	37	chr4	175896931	175896931	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgtgttcacctacacagaCcagggtgctatccttgagga	10	12	1	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr4:175896931C>T	uc003iuc.2	+	5	925	c.255C>T	c.(253-255)GAC>GAT	p.D85D	ADAM29_uc003iud.2_Silent_p.D85D|ADAM29_uc010irr.2_Silent_p.D85D|ADAM29_uc011cki.1_Silent_p.D85D	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	85					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding	p.D85E(1)		skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CCTACACAGACCAGGGTGCTA	0.473													T	175896931	T	T	175896931	2	4	11	1	0	0	0	0	0	0	0	1	247	506	18	3		3	ADAM29	4	175896931	Silent	SNP	C	TCGA-06-0124-01A-01D-1490-08	135456113	175896931	15257345	17	766											
SLC6A19	340024	broad.mit.edu	37	chr5	1208942	1208942	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagttcgccatcgggcagcGgctgcggcggggcagcctgg	20	12	0	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr5:1208942G>A	uc003jbw.3	+	2	340	c.284G>A	c.(283-285)CGG>CAG	p.R95Q		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	95	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ATCGGGCAGCGGCTGCGGCGG	0.677													A	1208942	A	A	1208942	3	1	11	1	0	0	0	0	1	0	0	0	14682	1116	39	2	290	2	SLC6A19	5	1208942	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		1208942	179706318	18	767											
BASP1	10409	broad.mit.edu	37	chr5	17275409	17275409	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagacaagaaggccgagggCgcggcgacggaagaggaggg	20	7	0	3			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr5:17275409C>T	uc003jfx.2	+	2	263	c.84C>T	c.(82-84)GGC>GGT	p.G28G		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	28					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						AGGCCGAGGGCGCGGCGACGG	0.627													T	17275409	T	T	17275409	2	4	11	1	0	0	0	0	0	0	0	1	1317	755	27	1		1	BASP1	5	17275409	Silent	SNP	C	TCGA-06-0124-01A-01D-1490-08	16066467	17275409	163639851	19	768											
HCN1	348980	broad.mit.edu	37	chr5	45262205	45262205	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgcgggacagtgctcctgcCccctgcctgaaggcccgttc	12	17	0	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr5:45262205C>A	uc003jok.2	-	8	2516	c.2491G>T	c.(2491-2493)GGC>TGC	p.G831C		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	831	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GTGCTCCTGCCCCCTGCCTGA	0.677													A	45262205	A	A	45262205	3	1	11	1	0	0	0	0	1	0	0	0	6996	623	22	5	185	5	HCN1	5	45262205	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	27986796	45262205	135653055	20	769											
VCAN	1462	broad.mit.edu	37	chr5	82808046	82808046	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcggcatggaggaacggcttTgaccagtgcgattacgggtg	17	8	0	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr5:82808046T>A	uc003kii.3	+	6	1229	c.873T>A	c.(871-873)TTT>TTA	p.F291L	VCAN_uc003kij.3_Missense_Mutation_p.F291L|VCAN_uc010jau.2_Missense_Mutation_p.F291L|VCAN_uc003kik.3_Missense_Mutation_p.F291L|VCAN_uc003kih.3_Missense_Mutation_p.F291L	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	291	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGAACGGCTTTGACCAGTGCG	0.602													A	82808046	A	A	82808046	3	1	11	1	0	0	0	0	1	0	0	0	17135	1809	63	5	891	5	VCAN	5	82808046	Missense_Mutation	SNP	T	TCGA-06-0124-01A-01D-1490-08	37545841	82808046	98107214	21	770											
FNIP1	96459	broad.mit.edu	37	chr5	131042146	131042146	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaacttgttgtttggctgCgtcgccaacgtcgctggtag	12	11	0	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr5:131042146C>T	uc003kvs.1	-	9	1014	c.872G>A	c.(871-873)CGC>CAC	p.R291H	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.R263H|FNIP1_uc010jdm.1_Missense_Mutation_p.R246H|FNIP1_uc003kvu.2_Missense_Mutation_p.R291H	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	291					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TGTTTGGCTGCGTCGCCAACG	0.438													T	131042146	T	T	131042146	3	4	11	1	0	0	0	0	1	0	0	0	5975	768	27	1	2668	1	FNIP1	5	131042146	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	48234100	131042146	49873114	22	771											
PCDHA12	56137	broad.mit.edu	37	chr5	140256419	140256419	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaacgacaatgcgcctgcGttcgcgcagcccgagtacac	12	14	0	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr5:140256419G>A	uc003lic.2	+	1	1489	c.1362G>A	c.(1360-1362)GCG>GCA	p.A454A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.A454A	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	454	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCGCCTGCGTTCGCGCAGC	0.652													A	140256419	A	A	140256419	2	1	11	1	0	0	0	0	0	0	0	1	11522	1132	40	1		1	PCDHA12	5	140256419	Silent	SNP	G	TCGA-06-0124-01A-01D-1490-08	9214273	140256419	40658841	23	772											
JAKMIP2	9832	broad.mit.edu	37	chr5	147040668	147040668	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttggccgttttcaggtccGcaatttcctgtaagagctta	9	10	2	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr5:147040668G>A	uc003loq.1	-	3	852	c.470C>T	c.(469-471)GCG>GTG	p.A157V	JAKMIP2_uc011dbx.1_Missense_Mutation_p.A115V|JAKMIP2_uc003lor.1_Missense_Mutation_p.A157V|uc003lop.1_3'UTR|JAKMIP2_uc010jgo.1_Missense_Mutation_p.A157V	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	157	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTCAGGTCCGCAATTTCCTG	0.542													A	147040668	A	A	147040668	3	1	11	1	0	0	0	0	1	0	0	0	7941	1087	38	1	2038	1	JAKMIP2	5	147040668	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	6784249	147040668	33874592	24	773											
COL23A1	91522	broad.mit.edu	37	chr5	177690250	177690250	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggggccatctttcccagtgtCgccaggagggccccgggccc	15	16	1	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr5:177690250C>T	uc003mje.2	-	9	956	c.598G>A	c.(598-600)GAC>AAC	p.D200N	COL23A1_uc010jkt.2_Silent_p.A47A	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	200	Extracellular (Potential).|Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		TTCCCAGTGTCGCCAGGAGGG	0.637													T	177690250	T	T	177690250	3	4	11	1	0	0	0	0	1	0	0	0	3682	884	31	2	1108	2	COL23A1	5	177690250	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	30649582	177690250	3225010	25	774											
RNF8	9025	broad.mit.edu	37	chr6	37336605	37336605	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacaggggaaaggtgaagtgGccagtacaccctctgacaat	12	10	1	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr6:37336605G>A	uc003onq.3	+	3	779	c.586G>A	c.(586-588)GCC>ACC	p.A196T	RNF8_uc003onr.3_Missense_Mutation_p.A196T|RNF8_uc011dtx.1_Missense_Mutation_p.A128T	NM_003958	NP_003949	O76064	RNF8_HUMAN	ring finger protein 8 isoform 1	196					cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						AGGTGAAGTGGCCAGTACACC	0.483													A	37336605	A	A	37336605	3	1	11	1	0	0	0	0	1	0	0	0	13500	1203	42	3	596	3	RNF8	6	37336605	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		37336605	133778462	26	775											
PEX6	5190	broad.mit.edu	37	chr6	42937419	42937419	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cactcaccctggctggaggcGaggcttcaggacagcacaga	13	13	2	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr6:42937419G>A	uc003otf.2	-	5	1447	c.1354C>T	c.(1354-1356)CGC>TGC	p.R452C	PEX6_uc010jya.2_RNA	NM_000287	NP_000278	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	452					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)	1			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			GGCTGGAGGCGAGGCTTCAGG	0.567													A	42937419	A	A	42937419	3	1	11	1	0	0	0	0	1	0	0	0	11750	1058	37	2	1640	2	PEX6	6	42937419	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	5600814	42937419	128177648	27	776											
RFX6	222546	broad.mit.edu	37	chr6	117243268	117243268	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaagaatgccactgtggaggCttttattgaatggttggata	13	4	0	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr6:117243268C>A	uc003pxm.2	+	13	1454	c.1391C>A	c.(1390-1392)GCT>GAT	p.A464D		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	464					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						ACTGTGGAGGCTTTTATTGAA	0.323													A	117243268	A	A	117243268	3	1	11	1	0	0	0	0	1	0	0	0	13267	797	28	5	1441	5	RFX6	6	117243268	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	74305849	117243268	53871799	28	777											
PTPRK	5796	broad.mit.edu	37	chr6	128388894	128388894	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catggctccggcttctctctTggttcggtgtgggtgcagtt	14	10	2	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr6:128388894T>C	uc003qbk.2	-	12	2294	c.1927A>G	c.(1927-1929)AAG>GAG	p.K643E	PTPRK_uc003qbj.2_Missense_Mutation_p.K643E|PTPRK_uc010kfc.2_Missense_Mutation_p.K643E|PTPRK_uc011ebu.1_Missense_Mutation_p.K643E|PTPRK_uc003qbl.1_Missense_Mutation_p.K513E|PTPRK_uc011ebv.1_Missense_Mutation_p.K643E	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	643	Extracellular (Potential).|Fibronectin type-III 4.	Cleavage (Probable).			cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GCTTCTCTCTTGGTTCGGTGT	0.448													C	128388894	C	C	128388894	3	2	11	1	0	0	0	0	1	0	0	0	12805	1821	63	4	2493	4	PTPRK	6	128388894	Missense_Mutation	SNP	T	TCGA-06-0124-01A-01D-1490-08	11145626	128388894	42726173	29	778											
TYW1B	441250	broad.mit.edu	37	chr7	72093938	72093938	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taggcctggagctcgtccacGttccatgctttcacgagcat	10	13	1	0	rs149299985	by1000genomes	TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr7:72093938G>A	uc011kej.1	-	15	1710	c.1551C>T	c.(1549-1551)AAC>AAT	p.N517N	TYW1B_uc011keh.1_Silent_p.N355N|TYW1B_uc011kei.1_Silent_p.N143N	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	517					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GCTCGTCCACGTTCCATGCTT	0.522													A	72093938	A	A	72093938	2	1	11	1	0	0	0	0	0	0	0	1	16816	1136	40	1		1	TYW1B	7	72093938	Silent	SNP	G	TCGA-06-0124-01A-01D-1490-08		72093938	87044725	30	779											
ABCB4	5244	broad.mit.edu	37	chr7	87104766	87104766	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggctgttccgttctttgCcgcctcaagatccatctcag	8	15	3	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr7:87104766C>T	uc003uiv.1	-	2	92	c.16G>A	c.(16-18)GCA>ACA	p.A6T	ABCB4_uc003uiw.1_Missense_Mutation_p.A6T|ABCB4_uc003uix.1_Missense_Mutation_p.A6T|ABCB4_uc003uiy.2_Missense_Mutation_p.A6T	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	6	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CCGTTCTTTGCCGCCTCAAGA	0.647													T	87104766	T	T	87104766	3	4	11	1	0	0	0	0	1	0	0	0	43	739	26	3	3952	3	ABCB4	7	87104766	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	15010828	87104766	72033897	31	780											
ZAN	7455	broad.mit.edu	37	chr7	100373053	100373053	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgtcctggtgaaagtgtgCcaccccgccatggccttgcc	11	15	0	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr7:100373053C>T	uc003uwj.2	+	33	6048	c.5883C>T	c.(5881-5883)TGC>TGT	p.C1961C	ZAN_uc003uwk.2_Silent_p.C1961C|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.C48C	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1961	Extracellular (Potential).|VWFD 3.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGAAAGTGTGCCACCCCGCCA	0.547													T	100373053	T	T	100373053	2	4	11	1	0	0	0	0	0	0	0	1	17510	747	26	3		3	ZAN	7	100373053	Silent	SNP	C	TCGA-06-0124-01A-01D-1490-08	13268287	100373053	58765610	32	781											
MUC17	140453	broad.mit.edu	37	chr7	100681607	100681607	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcaccctttcaacaactcctGttgactccaacactcctttc	3	17	1	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr7:100681607G>C	uc003uxp.1	+	3	6963	c.6910G>C	c.(6910-6912)GTT>CTT	p.V2304L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2304	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|36.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACAACTCCTGTTGACTCCAA	0.473													C	100681607	C	C	100681607	3	2	11	1	0	0	0	0	1	0	0	0	9974	1377	48	5	6920	5	MUC17	7	100681607	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	308554	100681607	58457056	33	782											
RELN	5649	broad.mit.edu	37	chr7	103130205	103130205	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaccttggaagctctcgtcGcagatgcagatggcaccggt	13	11	1	3			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr7:103130205G>A	uc003vca.2	-	60	9907	c.9747C>T	c.(9745-9747)TGC>TGT	p.C3249C	RELN_uc010liz.2_Silent_p.C3249C	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3249	EGF-like 8.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGCTCTCGTCGCAGATGCAGA	0.408													A	103130205	A	A	103130205	2	1	11	1	0	0	0	0	0	0	0	1	13220	1079	38	1		1	RELN	7	103130205	Silent	SNP	G	TCGA-06-0124-01A-01D-1490-08	2448598	103130205	56008458	34	783											
ADAM7	8756	broad.mit.edu	37	chr8	24365011	24365012	+	Missense_Mutation	DNP	TC	AA	AA													agaaacctgcaagtaaagatTcaagaggaatcgcagatccc							TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr8:24365011_24365012TC>AA	uc003xeb.2	+	21	2340_2341	c.2227_2228TC>AA	c.(2227-2229)TCA>AAA	p.S743K	ADAM7_uc003xec.2_Intron	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	743	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		AAGTAAAGATTCAAGAGGAATC	0.297													AA	24365012	AA	AA	24365011	3	1	11	1	0	0	0	0	1	0	0	0	251	1783	62	5	2309	5	ADAM7	8	24365011	Missense_Mutation	DNP	TC	TCGA-06-0124-01A-01D-1490-08		24365011	121999011	35	784											
DOCK5	80005	broad.mit.edu	37	chr8	25158172	25158172	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	taacctccaagcagtgtttaCagtaagtcctcccttctgtt	6	12	1	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr8:25158172C>G	uc003xeg.2	+	9	982	c.845C>G	c.(844-846)ACA>AGA	p.T282R	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Intron|DOCK5_uc003xef.2_Missense_Mutation_p.T282R	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	282						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GCAGTGTTTACAGTAAGTCCT	0.363													G	25158172	G	G	25158172	3	3	11	1	0	0	0	0	1	0	0	0	4690	492	17	5	879	5	DOCK5	8	25158172	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	793161	25158172	121205850	36	785											
EBF2	64641	broad.mit.edu	37	chr8	25715990	25715990	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctggaagagtatccccgcGgagagatgctgcttgtgttg	15	8	0	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr8:25715990G>A	uc003xes.1	-	14	1390	c.1373C>T	c.(1372-1374)CCG>CTG	p.P458L	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	458	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GTATCCCCGCGGAGAGATGCT	0.522													A	25715990	A	A	25715990	3	1	11	1	0	0	0	0	1	0	0	0	4881	1116	39	2	366	2	EBF2	8	25715990	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	557818	25715990	120648032	37	786											
TRPA1	8989	broad.mit.edu	37	chr8	72948651	72948651	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	atgcccgtcgtgtagataatCcattcaagaacattgcttat	7	9	1	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr8:72948651C>A	uc003xza.2	-	21	2602	c.2427G>T	c.(2425-2427)TGG>TGT	p.W809C	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	809	Helical; Name=3; (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TGTAGATAATCCATTCAAGAA	0.363													A	72948651	A	A	72948651	3	1	11	1	0	0	0	0	1	0	0	0	16574	856	30	5	960	5	TRPA1	8	72948651	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	47232661	72948651	73415371	38	787											
RIMS2	9699	broad.mit.edu	37	chr8	104930679	104930679	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcatttcagagatataccgCgaatacctgatagcacacat	6	10	2	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr8:104930679C>T	uc003yls.2	+	7	1622	c.1381C>T	c.(1381-1383)CGA>TGA	p.R461*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.R683*|RIMS2_uc003ylw.2_Nonsense_Mutation_p.R491*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.R491*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.R538*|RIMS2_uc003ylt.2_Nonsense_Mutation_p.R84*|RIMS2_uc003ylu.1_Nonsense_Mutation_p.R74*|RIMS2_uc003ylv.1_Nonsense_Mutation_p.R74*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	761					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGATATACCGCGAATACCTGA	0.299										HNSCC(12;0.0054)			T	104930679	T	T	104930679	4	4	11	1	0	0	0	0	0	1	0	0	13368	760	27	1	2207	1	RIMS2	8	104930679	Nonsense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	31982028	104930679	41433343	39	788											
RIMS2	9699	broad.mit.edu	37	chr8	105264036	105264036	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agttcaactggaccttcttaCtctcgttcatagcagctgta	7	11	4	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr8:105264036C>A	uc003yls.2	+	28	4333	c.4092C>A	c.(4090-4092)TAC>TAA	p.Y1364*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.Y1346*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.Y1160*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.Y1185*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1408					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GACCTTCTTACTCTCGTTCAT	0.423										HNSCC(12;0.0054)			A	105264036	A	A	105264036	4	1	11	1	0	0	0	0	0	1	0	0	13368	576	20	5	4328	5	RIMS2	8	105264036	Nonsense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	333357	105264036	41099986	40	789											
SMARCA2	6595	broad.mit.edu	37	chr9	2039586	2039586	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgggggccctcatcccagGtgatccgcaggccatgagcc	14	16	1	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr9:2039586G>A	uc003zhc.2	+	4	575	c.476G>A	c.(475-477)GGT>GAT	p.G159D	SMARCA2_uc003zhd.2_Missense_Mutation_p.G159D|SMARCA2_uc010mha.2_Missense_Mutation_p.G150D	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	159					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CTCATCCCAGGTGATCCGCAG	0.582													A	2039586	A	A	2039586	3	1	11	1	0	0	0	0	1	0	0	0	14769	1261	44	3	486	3	SMARCA2	9	2039586	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		2039586	139173845	41	790											
VCP	7415	broad.mit.edu	37	chr9	35059646	35059647	+	Frame_Shift_Ins	INS	-	T	T													tagcgccaatgatgaacacaINStttttttttgtggacatgcc							TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr9:35059646_35059647insT	uc003zvy.2	-	14	2236_2237	c.1847_1848insA	c.(1846-1848)AATfs	p.N616fs	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Frame_Shift_Ins_p.N285fs|VCP_uc010mki.1_Frame_Shift_Ins_p.N571fs	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	616					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGATGAACACATTTTTTTTTGT	0.515													T	35059647	T	T	35059646	7	5	11	1	0	1	1	0	0	0	0	0	17137	214	8	0	588	0	VCP	9	35059646	Frame_Shift_Ins	INS	-	TCGA-06-0124-01A-01D-1490-08	33020060	35059646	106153785	42	791											
DAB2IP	153090	broad.mit.edu	37	chr9	124535257	124535257	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcacctccgagggcgcgcCaggccggccccagctgttgg	16	16	0	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr9:124535257C>T	uc004bln.2	+	12	2435	c.2366C>T	c.(2365-2367)CCA>CTA	p.P789L	DAB2IP_uc004blo.2_Missense_Mutation_p.P693L|DAB2IP_uc004blp.2_Missense_Mutation_p.P222L	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	817					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						GAGGGCGCGCCAGGCCGGCCC	0.726													T	124535257	T	T	124535257	3	4	11	1	0	0	0	0	1	0	0	0	4219	594	21	3	2412	3	DAB2IP	9	124535257	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	89475611	124535257	16678174	43	792											
RBM18	92400	broad.mit.edu	37	chr9	125004210	125004210	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agaatatggagtagtcctttTtttatctggtggcttaaagt	10	4	1	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr9:125004210T>A	uc004bma.2	-	6	692	c.526A>T	c.(526-528)AAA>TAA	p.K176*	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_RNA	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	176							nucleotide binding|RNA binding				0						GTAGTCCTTTTTTTATCTGGT	0.398													A	125004210	A	A	125004210	4	1	11	1	0	0	0	0	0	1	0	0	13120	1850	64	5	50	5	RBM18	9	125004210	Nonsense_Mutation	SNP	T	TCGA-06-0124-01A-01D-1490-08	468953	125004210	16209221	44	793			1	4		2	2	18	N	T_A	4.118566e-05
RBM18	92400	broad.mit.edu	37	chr9	125004227	125004227	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttttttatctggtggcttaAagtaggaataaacaggcgct	10	5	1	0	rs111532590		TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr9:125004227A>C	uc004bma.2	-	6	675	c.509T>G	c.(508-510)TTT>TGT	p.F170C	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_RNA	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	170							nucleotide binding|RNA binding				0						TGGTGGCTTAAAGTAGGAATA	0.403													C	125004227	C	C	125004227	3	2	11	1	0	0	0	0	1	0	0	0	13120	14	1	5	67	5	RBM18	9	125004227	Missense_Mutation	SNP	A	TCGA-06-0124-01A-01D-1490-08	17	125004227	16209204	45	794			1	4		2	2	18	N	T_A	4.118566e-05
CCNY	219771	broad.mit.edu	37	chr10	35819172	35819172	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgtgccatcgtcaccctgGtgagtgccctcaggatggcc	12	13	2	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr10:35819172G>A	uc001iyw.3	+	7	759	c.579_splice	c.e7+1	p.L193_splice	CCNY_uc001iyu.3_Splice_Site_p.L139_splice|CCNY_uc001iyv.3_Splice_Site_p.L139_splice|CCNY_uc001iyx.3_Splice_Site_p.L139_splice|CCNY_uc009xmb.2_Splice_Site_p.L168_splice|CCNY_uc010qet.1_Splice_Site_p.L60_splice	NM_145012	NP_659449	Q8ND76	CCNY_HUMAN	cyclin Y isoform 1						cell division|G2/M transition of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	cyclin-dependent protein kinase regulator activity|protein kinase binding				0						CGTCACCCTGGTGAGTGCCCT	0.577													A	35819172	A	A	35819172	5	1	11	1	0	0	0	0	0	0	1	0	2936	1275	44	3	606	3	CCNY	10	35819172	Splice_Site	SNP	G	TCGA-06-0124-01A-01D-1490-08		35819172	99715575	46	795											
PTEN	5728	broad.mit.edu	37	chr10	89720679	89720679	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttcacttttgggtaaataCattcttcataccaggaccag	7	9	3	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr10:89720679C>T	uc001kfb.2	+	9	1861	c.830C>T	c.(829-831)ACA>ATA	p.T277I		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	277	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.D268_F279>VGQNVSLLGKYI(2)|p.G165_*404del(1)|p.G165_K342del(1)|p.T277I(1)|p.W274_F341del(1)|p.T277fs*13(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGGGTAAATACATTCTTCATA	0.259		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89720679	T	T	89720679	3	4	11	1	0	0	0	0	1	0	0	0	12738	478	17	3	860	3	PTEN	10	89720679	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	53901507	89720679	45814068	47	796											
HPS6	79803	broad.mit.edu	37	chr10	103827534	103827534	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgggaccccagcactccacCcccgactccacctcgggacc	8	21	0	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr10:103827534C>T	uc001kuj.2	+	1	2388	c.2303C>T	c.(2302-2304)CCC>CTC	p.P768L		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	768						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		AGCACTCCACCCCCGACTCCA	0.592									Hermansky-Pudlak_syndrome				T	103827534	T	T	103827534	3	4	11	1	0	0	0	0	1	0	0	0	7343	623	22	3	2305	3	HPS6	10	103827534	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	14106855	103827534	31707213	48	797											
KRTAP5-4	387267	broad.mit.edu	37	chr11	1643000	1643000	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacaggagccacagcccccCttggagcccccacaggagcc	10	20	0	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr11:1643000C>T	uc009ycy.1	-	3	549	c.462G>A	c.(460-462)AAG>AAA	p.K154K		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	168	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CACAGCCCCCCTTGGAGCCCC	0.682													T	1643000	T	T	1643000	2	4	11	1	0	0	0	0	0	0	0	1	8563	680	24	3		3	KRTAP5-4	11	1643000	Silent	SNP	C	TCGA-06-0124-01A-01D-1490-08		1643000	133363516	49	798											
NAP1L4	4676	broad.mit.edu	37	chr11	2975821	2975821	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgcgggactatccgctcaCggaaaaagtgtccaatttca	9	13	2	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr11:2975821C>T	uc001lxc.2	-	12	1112	c.971G>A	c.(970-972)CGT>CAT	p.R324H	NAP1L4_uc001lxb.2_5'Flank|NAP1L4_uc009ydt.2_RNA|NAP1L4_uc010qxm.1_Missense_Mutation_p.R324H|NAP1L4_uc010qxn.1_Missense_Mutation_p.R324H	NM_005969	NP_005960	Q99733	NP1L4_HUMAN	nucleosome assembly protein 1-like 4	324					nucleosome assembly	chromatin assembly complex|cytoplasm	unfolded protein binding			ovary(1)	1		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00301)|LUSC - Lung squamous cell carcinoma(625;0.211)		TATCCGCTCACGGAAAAAGTG	0.473													T	2975821	T	T	2975821	3	4	11	1	0	0	0	0	1	0	0	0	10159	536	19	1	172	1	NAP1L4	11	2975821	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	1332821	2975821	132030695	50	799											
OR52K1	390036	broad.mit.edu	37	chr11	4510426	4510426	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggagatcaacttctttgcctGtctggtccagatgttcttcc	9	11	4	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr11:4510426G>C	uc001lza.1	+	1	296	c.296G>C	c.(295-297)TGT>TCT	p.C99S		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		TTCTTTGCCTGTCTGGTCCAG	0.502													C	4510426	C	C	4510426	3	2	11	1	0	0	0	0	1	0	0	0	11123	1377	48	5	298	5	OR52K1	11	4510426	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	1534605	4510426	130496090	51	800											
HTR3A	3359	broad.mit.edu	37	chr11	113856764	113856764	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcaacatctctttgtggcGcttgccagaaaaggtgaaat	9	9	2	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr11:113856764G>A	uc010rxb.1	+	6	823	c.590G>A	c.(589-591)CGC>CAC	p.R197H	HTR3A_uc010rxa.1_Missense_Mutation_p.R197H|HTR3A_uc009yyx.2_Intron|HTR3A_uc010rxc.1_Missense_Mutation_p.R176H	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	191	Extracellular (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	TCTTTGTGGCGCTTGCCAGAA	0.522													A	113856764	A	A	113856764	3	1	11	1	0	0	0	0	1	0	0	0	7444	1087	38	1	638	1	HTR3A	11	113856764	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	109346338	113856764	21149752	52	801											
AMICA1	120425	broad.mit.edu	37	chr11	118074267	118074267	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttgaagcatgatggaaccGtcattgcggaaaatgtcccc	10	11	1	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr11:118074267G>A	uc001psk.2	-	6	822	c.648C>T	c.(646-648)GAC>GAT	p.D216D	AMICA1_uc001psg.2_Silent_p.D26D|AMICA1_uc001psh.2_Silent_p.D177D|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Silent_p.D206D|AMICA1_uc001psj.2_Silent_p.D205D|AMICA1_uc010rxw.1_Silent_p.D177D|AMICA1_uc010rxx.1_Silent_p.D216D|AMICA1_uc001psl.1_Silent_p.D172D	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	216	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TGATGGAACCGTCATTGCGGA	0.512													A	118074267	A	A	118074267	2	1	11	1	0	0	0	0	0	0	0	1	574	1136	40	1		1	AMICA1	11	118074267	Silent	SNP	G	TCGA-06-0124-01A-01D-1490-08	4217503	118074267	16932249	53	802											
LPAR5	57121	broad.mit.edu	37	chr12	6729601	6729601	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccccgcgcacgcgatcgcGggcaggcacgctggccgcca	14	19	0	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr12:6729601G>A	uc009zer.2	-	2	1095	c.814C>T	c.(814-816)CGC>TGC	p.R272C	LPAR5_uc001qps.2_Missense_Mutation_p.R272C|LPAR5_uc010sff.1_Missense_Mutation_p.R272C	NM_001142961	NP_001136433	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	272	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2						ACGCGATCGCGGGCAGGCACG	0.667													A	6729601	A	A	6729601	3	1	11	1	0	0	0	0	1	0	0	0	8908	1116	39	2	308	2	LPAR5	12	6729601	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		6729601	127122294	54	803											
PTPN6	5777	broad.mit.edu	37	chr12	7069104	7069104	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccagcgccggcatcggccGcacaggcaccatcattgtca	10	18	2	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr12:7069104G>A	uc001qsb.2	+	12	1618	c.1376G>A	c.(1375-1377)CGC>CAC	p.R459H	PTPN6_uc001qsa.1_Missense_Mutation_p.R461H|PTPN6_uc010sfr.1_Missense_Mutation_p.R420H|PTPN6_uc009zfl.1_Missense_Mutation_p.R459H|PTPN6_uc010sfs.1_Missense_Mutation_p.R447H	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	459	Tyrosine-protein phosphatase.|Substrate binding (By similarity).				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						GGCATCGGCCGCACAGGCACC	0.672													A	7069104	A	A	7069104	3	1	11	1	0	0	0	0	1	0	0	0	12792	1087	38	1	1440	1	PTPN6	12	7069104	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	339503	7069104	126782791	55	804											
KLRC3	3823	broad.mit.edu	37	chr12	10573119	10573119	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgggtcctgggccagactcaCttctgagaaggttcctcttt	11	11	3	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr12:10573119C>A	uc001qyf.2	-	1	76	c.31G>T	c.(31-33)GTG>TTG	p.V11L	KLRC3_uc001qyh.2_Intron|KLRC3_uc001qyi.1_Missense_Mutation_p.V11L|KLRC3_uc010shc.1_Missense_Mutation_p.V11L|KLRC3_uc010shd.1_Missense_Mutation_p.V11L	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	11	Cytoplasmic (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						GCCAGACTCACTTCTGAGAAG	0.423													A	10573119	A	A	10573119	3	1	11	1	0	0	0	0	1	0	0	0	8417	565	20	5	815	5	KLRC3	12	10573119	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	3504015	10573119	123278776	56	805											
KLRC3	3823	broad.mit.edu	37	chr12	10588555	10588555	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgggtcctgggccagactcaCttctgagaaggttcctcttt	11	11	3	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr12:10588555C>A	uc001qyh.2	-	1	38	c.31G>T	c.(31-33)GTG>TTG	p.V11L	KLRC2_uc010she.1_Missense_Mutation_p.V11L|KLRC2_uc001qyk.2_Missense_Mutation_p.V11L	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	11	Cytoplasmic (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						GCCAGACTCACTTCTGAGAAG	0.423													A	10588555	A	A	10588555	3	1	11	1	0	0	0	0	1	0	0	0	8417	565	20	5		5	KLRC3	12	10588555	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	15436	10588555	123263340	57	806											
ADAMTS20	80070	broad.mit.edu	37	chr12	43944924	43944924	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgcccgtaggcagtgaagcGatagtgggttcggaacggca	16	9	0	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr12:43944924G>A	uc010skx.1	-	2	241	c.241C>T	c.(241-243)CGC>TGC	p.R81C		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	81						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GCAGTGAAGCGATAGTGGGTT	0.617													A	43944924	A	A	43944924	3	1	11	1	0	0	0	0	1	0	0	0	266	1058	37	2	5642	2	ADAMTS20	12	43944924	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	33356369	43944924	89906971	58	807											
TTC8	123016	broad.mit.edu	37	chr14	89336533	89336533	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcagccagaaatagctctccGgttttacaggtgcacttcac	8	12	3	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr14:89336533G>T	uc010ath.2	+	11	1222	c.1088G>T	c.(1087-1089)CGG>CTG	p.R363L	TTC8_uc001xxl.2_Missense_Mutation_p.R108L|TTC8_uc010ati.2_Missense_Mutation_p.R149L|TTC8_uc001xxm.2_Missense_Mutation_p.R307L|TTC8_uc010atj.2_Missense_Mutation_p.R82L|TTC8_uc001xxi.2_Missense_Mutation_p.R347L|TTC8_uc001xxj.2_Missense_Mutation_p.R337L|TTC8_uc001xxk.2_Missense_Mutation_p.R307L	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	373	TPR 5.				cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						ATAGCTCTCCGGTTTTACAGG	0.358									Bardet-Biedl_syndrome				T	89336533	T	T	89336533	3	4	11	1	0	0	0	0	1	0	0	0	16711	1116	39	5	1082	5	TTC8	14	89336533	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		89336533	18013007	59	808											
DIO3	1735	broad.mit.edu	37	chr14	102028704	102028704	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctgcgcacttggttggaaCgctatgatgagcaactgcac	12	10	0	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr14:102028704C>T	uc010txq.1	+	2	1017	c.793C>T	c.(793-795)CGC>TGC	p.R265C	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	265	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				TTGGTTGGAACGCTATGATGA	0.592													T	102028704	T	T	102028704	3	4	11	1	0	0	0	0	1	0	0	0	4526	536	19	1	873	1	DIO3	14	102028704	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	12692171	102028704	5320836	60	809											
SEPT12	124404	broad.mit.edu	37	chr16	4836007	4836007	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagtgaatgcagctgcagcGtctggggtgtgggcaccccc	15	12	2	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr16:4836007G>A	uc002cxq.2	-	3	407	c.266C>T	c.(265-267)ACG>ATG	p.T89M	SEPT12_uc002cxr.2_Missense_Mutation_p.T89M|SEPT12_uc010bty.2_RNA|uc002cxt.2_5'Flank	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	89		GTP (By similarity).			cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						CAGCTGCAGCGTCTGGGGTGT	0.512													A	4836007	A	A	4836007	3	1	11	1	0	0	0	0	1	0	0	0	14062	1145	40	1	842	1	SEPT12	16	4836007	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		4836007	85518746	61	810											
ZNF768	79724	broad.mit.edu	37	chr16	30535933	30535933	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atcgcacttgtaaggccgctCgccactgtggacccggtgat	12	13	0	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr16:30535933C>T	uc002dyk.3	-	2	1704	c.1528G>A	c.(1528-1530)GAG>AAG	p.E510K	ZNF768_uc010vex.1_Missense_Mutation_p.E479K|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.E479K	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	510					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						TAAGGCCGCTCGCCACTGTGG	0.701													T	30535933	T	T	30535933	3	4	11	1	0	0	0	0	1	0	0	0	18138	893	31	2	98	2	ZNF768	16	30535933	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	25699926	30535933	59818820	62	811											
CAMKK1	84254	broad.mit.edu	37	chr17	3779601	3779601	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgtgctggacagctgagcGtcgttcccctcaaactggtt	12	13	1	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr17:3779601G>A	uc002fwt.2	-	10	1006	c.912C>T	c.(910-912)GAC>GAT	p.D304D	CAMKK1_uc002fwu.2_Silent_p.D304D|CAMKK1_uc002fwv.2_Silent_p.D342D	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	304	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		ACAGCTGAGCGTCGTTCCCCT	0.612													A	3779601	A	A	3779601	2	1	11	1	0	0	0	0	0	0	0	1	2606	1136	40	1		1	CAMKK1	17	3779601	Silent	SNP	G	TCGA-06-0124-01A-01D-1490-08		3779601	77415609	63	812											
NF1	4763	broad.mit.edu	37	chr17	29662002	29662002	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatgaccatcaatgaaaaaCagatgtacccatctattcaa	4	10	3	3			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr17:29662002C>T	uc002hgg.2	+	40	6292	c.5959C>T	c.(5959-5961)CAG>TAG	p.Q1987*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q1966*|NF1_uc010cso.2_Nonsense_Mutation_p.Q175*|NF1_uc010wbt.1_5'Flank|NF1_uc010wbu.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1987					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.Q1987*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CAATGAAAAACAGATGTACCC	0.348			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29662002	T	T	29662002	4	4	11	1	0	0	0	0	0	1	0	0	10356	479	17	3	6178	3	NF1	17	29662002	Nonsense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	25882401	29662002	51533208	64	813											
NF1	4763	broad.mit.edu	37	chr17	29667596	29667596	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tgatgaggtcaacttgtattCagcaggtaccgcacttcttg	10	9	3	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr17:29667596C>A	uc002hgg.2	+	47	7328	c.6995C>A	c.(6994-6996)TCA>TAA	p.S2332*	NF1_uc002hgh.2_Nonsense_Mutation_p.S2311*|NF1_uc010cso.2_Nonsense_Mutation_p.S520*|NF1_uc010wbt.1_5'UTR|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2332					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.S2332*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AACTTGTATTCAGCAGGTACC	0.448			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29667596	A	A	29667596	4	1	11	1	0	0	0	0	0	1	0	0	10356	838	29	5	7242	5	NF1	17	29667596	Nonsense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	5594	29667596	51527614	65	814											
KRT37	8688	broad.mit.edu	37	chr17	39578641	39578641	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggtgggctcaatgtccagctCgatccggaacttctccccca	10	15	2	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr17:39578641C>T	uc002hwp.1	-	4	825	c.778G>A	c.(778-780)GAG>AAG	p.E260K	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	260	Linker 12.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				ATGTCCAGCTCGATCCGGAAC	0.552													T	39578641	T	T	39578641	3	4	11	1	0	0	0	0	1	0	0	0	8474	893	31	2	587	2	KRT37	17	39578641	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	9911045	39578641	41616569	66	815											
CLEC4M	10332	broad.mit.edu	37	chr19	7831634	7831634	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcggaactggcacgactccGtcaccgcctgccaggaagtg	13	14	1	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr19:7831634G>A	uc002mih.2	+	6	926	c.808G>A	c.(808-810)GTC>ATC	p.V270I	CLEC4M_uc010xjv.1_3'UTR|CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Missense_Mutation_p.V226I|CLEC4M_uc010dvt.2_Missense_Mutation_p.V247I|CLEC4M_uc010dvs.2_Missense_Mutation_p.V269I|CLEC4M_uc010xjx.1_Missense_Mutation_p.V242I|CLEC4M_uc002mhz.2_Missense_Mutation_p.V201I|CLEC4M_uc002mic.2_Missense_Mutation_p.V265I|CLEC4M_uc002mia.2_Missense_Mutation_p.V157I	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	293	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						GCACGACTCCGTCACCGCCTG	0.597													A	7831634	A	A	7831634	3	1	11	1	0	0	0	0	1	0	0	0	3518	1145	40	1	916	1	CLEC4M	19	7831634	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		7831634	51297349	67	816											
NCAN	1463	broad.mit.edu	37	chr19	19337603	19337603	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gccctagcgacatgggggcaGgcactgcagcaagttcacac	13	13	1	0			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr19:19337603G>C	uc002nlz.2	+	7	1480	c.1381G>C	c.(1381-1383)GGC>CGC	p.G461R	NCAN_uc010ecc.1_Missense_Mutation_p.G25R	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	461					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CATGGGGGCAGGCACTGCAGC	0.642													C	19337603	C	C	19337603	3	2	11	1	0	0	0	0	1	0	0	0	10204	1000	35	5	1403	5	NCAN	19	19337603	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08	11505969	19337603	39791380	68	817											
PAPL	390928	broad.mit.edu	37	chr19	39591969	39591969	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcatgagcactcgtatgaaCgactgtggccaatttacaac	8	11	1	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr19:39591969C>T	uc002oki.2	+	10	1289	c.1015C>T	c.(1015-1017)CGA>TGA	p.R339*	PAPL_uc010egl.2_Silent_p.N297N	NM_001004318	NP_001004318	Q6ZNF0	PAPL_HUMAN	iron/zinc purple acid phosphatase-like protein	339						extracellular region	acid phosphatase activity|metal ion binding				0						CTCGTATGAACGACTGTGGCC	0.597													T	39591969	T	T	39591969	4	4	11	1	0	0	0	0	0	1	0	0	11427	528	19	1	1049	1	PAPL	19	39591969	Nonsense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	20254366	39591969	19537014	69	818											
RSPO4	343637	broad.mit.edu	37	chr20	947858	947858	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgggccaaagtgcccggcGggcaggtgggcagacacttc	18	11	0	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr20:947858G>A	uc002wej.2	-	3	465	c.368C>T	c.(367-369)CCG>CTG	p.P123L	RSPO4_uc002wek.2_Missense_Mutation_p.P123L	NM_001029871	NP_001025042	Q2I0M5	RSPO4_HUMAN	R-spondin family, member 4 isoform 1 precursor	123	FU.				Wnt receptor signaling pathway	extracellular region	heparin binding				0						AGTGCCCGGCGGGCAGGTGGG	0.647													A	947858	A	A	947858	3	1	11	1	0	0	0	0	1	0	0	0	13712	1116	39	2	348	2	RSPO4	20	947858	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		947858	62077662	70	819											
POTED	317754	broad.mit.edu	37	chr21	14982928	14982928	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggagactacgaccacagcGccttcatggagccgaggtac	14	12	1	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr21:14982928G>A	uc002yjb.1	+	1	431	c.379G>A	c.(379-381)GCC>ACC	p.A127T		NM_174981	NP_778146	Q86YR6	POTED_HUMAN	pote protein	127						plasma membrane				ovary(3)|skin(3)	6						CGACCACAGCGCCTTCATGGA	0.597													A	14982928	A	A	14982928	3	1	11	1	0	0	0	0	1	0	0	0	12263	1087	38	1	381	1	POTED	21	14982928	Missense_Mutation	SNP	G	TCGA-06-0124-01A-01D-1490-08		14982928	33146967	71	820											
PRDM15	63977	broad.mit.edu	37	chr21	43291677	43291677	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtgtcggacacctcattcCctagagatgtttccaagagc	9	12	1	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr21:43291677C>T	uc002yzq.1	-	4	578	c.467G>A	c.(466-468)GGG>GAG	p.G156E	PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACCTCATTCCCTAGAGATGT	0.582													T	43291677	T	T	43291677	3	4	11	1	0	0	0	0	1	0	0	0	12456	623	22	3	4168	3	PRDM15	21	43291677	Missense_Mutation	SNP	C	TCGA-06-0124-01A-01D-1490-08	28308749	43291677	4838218	72	821											
MICAL3	57553	broad.mit.edu	37	chr22	18274039	18274039	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agcttgaaccactcctgcatCagcttggggtcgtccttctt	9	13	2	1			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr22:18274039C>A	uc002zng.3	-	30	6032	c.5679G>T	c.(5677-5679)CTG>CTT	p.L1893L	MICAL3_uc011agl.1_Silent_p.L1809L|MICAL3_uc010grd.1_Silent_p.L9L|MICAL3_uc010gre.1_RNA	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1893	Potential.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		ACTCCTGCATCAGCTTGGGGT	0.632													A	18274039	A	A	18274039	2	1	11	1	0	0	0	0	0	0	0	1	9571	813	29	5		5	MICAL3	22	18274039	Silent	SNP	C	TCGA-06-0124-01A-01D-1490-08		18274039	33030527	73	822											
NAGA	4668	broad.mit.edu	37	chr22	42458930	42458930	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttctgggcggagatggtacgCaggtctgtggacatcaagag	16	7	3	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr22:42458930C>G	uc003bbx.2	-	8	995	c.858G>C	c.(856-858)CTG>CTC	p.L286L	NAGA_uc003bby.2_Silent_p.L286L|NAGA_uc003bbw.3_Silent_p.L286L	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	286					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						AGATGGTACGCAGGTCTGTGG	0.557													G	42458930	G	G	42458930	2	3	11	1	0	0	0	0	0	0	0	1	10141	697	25	5		5	NAGA	22	42458930	Silent	SNP	C	TCGA-06-0124-01A-01D-1490-08	24184891	42458930	8845636	74	823											
PKDREJ	10343	broad.mit.edu	37	chr22	46655208	46655208	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgaaatgttctgtccaaagTggtatcaacagaaagccatt	9	7	2	2			TCGA-06-0124-01A-01D-1490-08	TCGA-06-0124-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ae82bf8-7076-43fb-a541-4c7db5d49280	618c927a-48c5-446e-9af1-6456f7cfad71	g.chr22:46655208T>G	uc003bhh.2	-	1	4012	c.4012A>C	c.(4012-4014)ACT>CCT	p.T1338P		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1338	Cytoplasmic (Potential).|PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CTGTCCAAAGTGGTATCAACA	0.398													G	46655208	G	G	46655208	3	3	11	1	0	0	0	0	1	0	0	0	11970	1696	59	5	2753	5	PKDREJ	22	46655208	Missense_Mutation	SNP	T	TCGA-06-0124-01A-01D-1490-08	4196278	46655208	4649358	75	824											
NPHP4	261734	broad.mit.edu	37	chr1	5969224	5969224	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggacttacccctggtcccacAggtgagttctgcggggcagc	14	13	1	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:5969224A>T	uc001alq.1	-	12	1757	c.1491T>A	c.(1489-1491)CCT>CCA	p.P497P	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_Intron|NPHP4_uc001alt.1_Intron	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	497					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		CTGGTCCCACAGGTGAGTTCT	0.597													T	5969224	T	T	5969224	2	4	12	1	0	0	0	0	0	0	0	1	10581	175	7	5		5	NPHP4	1	5969224	Silent	SNP	A	TCGA-06-0126-01A-01D-1490-08		5969224	243281397	1	825											
TNFRSF1B	7133	broad.mit.edu	37	chr1	12253032	12253032	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acttaccccagccagtgtccAcacgatcccaacacacgcag	6	18	0	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:12253032A>C	uc001att.2	+	6	753	c.664A>C	c.(664-666)ACA>CCA	p.T222P	TNFRSF1B_uc001atu.2_Missense_Mutation_p.T27P|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	222	Extracellular (Potential).				apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity	p.T222P(1)		liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GCCAGTGTCCACACGATCCCA	0.637													C	12253032	C	C	12253032	3	2	12	1	0	0	0	0	1	0	0	0	16291	159	6	5	686	5	TNFRSF1B	1	12253032	Missense_Mutation	SNP	A	TCGA-06-0126-01A-01D-1490-08	6283808	12253032	236997589	2	826											
THRAP3	9967	broad.mit.edu	37	chr1	36752347	36752347	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catagccgagttgaatcttcTaagcgcaagtctgcaaagga	10	9	3	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:36752347T>C	uc001cae.3	+	4	740	c.516T>C	c.(514-516)TCT>TCC	p.S172S	THRAP3_uc001caf.3_Silent_p.S172S|THRAP3_uc001cag.1_Silent_p.S172S	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	172	Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TTGAATCTTCTAAGCGCAAGT	0.527			T	USP6	aneurysmal bone cysts								C	36752347	C	C	36752347	2	2	12	1	0	0	0	0	0	0	0	1	15871	1509	53	4		4	THRAP3	1	36752347	Silent	SNP	T	TCGA-06-0126-01A-01D-1490-08	24499315	36752347	212498274	3	827											
C8A	731	broad.mit.edu	37	chr1	57383364	57383364	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggggcctcgtgtccagggcGgaaagtacagacgcaggctt	16	10	0	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:57383364G>A	uc001cyo.2	+	11	1862	c.1730G>A	c.(1729-1731)CGG>CAG	p.R577Q		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	577	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						TGTCCAGGGCGGAAAGTACAG	0.557													A	57383364	A	A	57383364	3	1	12	1	0	0	0	0	1	0	0	0	2416	1116	39	2	1772	2	C8A	1	57383364	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08	20631017	57383364	191867257	4	828											
LPAR3	23566	broad.mit.edu	37	chr1	85331129	85331142	+	Frame_Shift_Del	DEL	ACTTGTATGCGGAG	-	-													ctccggcggctgatggacccActtgtatgcggagacaagac					rs140283678		TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:85331129_85331142delACTTGTATGCGGAG	uc001dkl.2	-	1	701_714	c.662_675delCTCCGCATACAAGT	c.(661-675)TCTCCGCATACAAGTfs	p.S221fs	LPAR3_uc009wcj.1_Frame_Shift_Del_p.S221fs	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	221_225	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						TGATGGACCCACTTGTATGCGGAGACAAGACGTT	0.5													-	85331142	-	-	85331129	7	5	12	1	0	1	0	1	0	0	0	0	8906	156	6	0	394	0	LPAR3	1	85331129	Frame_Shift_Del	DEL	ACTTGTATGCGGAG	TCGA-06-0126-01A-01D-1490-08	27947765	85331129	163919492	5	829											
SYDE2	84144	broad.mit.edu	37	chr1	85648703	85648703	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcccttaacgcttagctttCggctaaattctggcaacttt	6	11	1	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:85648703C>T	uc009wcm.2	-	3	1671	c.1622G>A	c.(1621-1623)CGA>CAA	p.R541Q	SYDE2_uc001dku.3_Missense_Mutation_p.R541Q	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	541					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		GCTTAGCTTTCGGCTAAATTC	0.338													T	85648703	T	T	85648703	3	4	12	1	0	0	0	0	1	0	0	0	15433	884	31	2	1982	2	SYDE2	1	85648703	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	317574	85648703	163601918	6	830											
KCNA10	3744	broad.mit.edu	37	chr1	111060591	111060591	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acgatgcaggtagactccacCatgaagaaagggtcggtgaa	13	8	0	4			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:111060591C>A	uc001dzt.1	-	1	1207	c.819G>T	c.(817-819)ATG>ATT	p.M273I		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	273	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		TAGACTCCACCATGAAGAAAG	0.532													A	111060591	A	A	111060591	3	1	12	1	0	0	0	0	1	0	0	0	8002	594	21	5	720	5	KCNA10	1	111060591	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	25411888	111060591	138190030	7	831											
FLG2	388698	broad.mit.edu	37	chr1	152326339	152326339	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtagttccttgtcttctgCgaactgtggatcctgacttt	10	9	2	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:152326339C>T	uc001ezw.3	-	3	3996	c.3923G>A	c.(3922-3924)CGC>CAC	p.R1308H	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1308							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGTCTTCTGCGAACTGTGGA	0.473													T	152326339	T	T	152326339	3	4	12	1	0	0	0	0	1	0	0	0	5923	768	27	1	3256	1	FLG2	1	152326339	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	41265748	152326339	96924282	8	832											
ETV3L	440695	broad.mit.edu	37	chr1	157068567	157068567	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcccccagcagcaagtggggGgatggcggcgcccgcacttc	16	15	0	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:157068567G>T	uc001fqq.1	-	3	702	c.417C>A	c.(415-417)TCC>TCA	p.S139S		NM_001004341	NP_001004341	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	139						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Hepatocellular(266;0.158)	Prostate(1639;0.184)				GCAAGTGGGGGGATGGCGGCG	0.602													T	157068567	T	T	157068567	2	4	12	1	0	0	0	0	0	0	0	1	5280	1219	43	5		5	ETV3L	1	157068567	Silent	SNP	G	TCGA-06-0126-01A-01D-1490-08	4742228	157068567	92182054	9	833											
PVRL4	81607	broad.mit.edu	37	chr1	161043074	161043074	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggccctcggctctcagccCtacactctcctccggctgca	9	19	2	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:161043074C>T	uc001fxo.2	-	8	1548	c.1249G>A	c.(1249-1251)GGG>AGG	p.G417R	PVRL4_uc010pjy.1_Intron|PVRL4_uc010pjz.1_Intron	NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	417	Cytoplasmic (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GCTCTCAGCCCTACACTCTCC	0.652													T	161043074	T	T	161043074	3	4	12	1	0	0	0	0	1	0	0	0	12842	681	24	3	291	3	PVRL4	1	161043074	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	3974507	161043074	88207547	10	834											
RGS1	5996	broad.mit.edu	37	chr1	192547487	192547487	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agcagaagagatatataaagCatttgtgcattcagatgctg	10	5	1	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr1:192547487C>G	uc001gsi.1	+	4	482	c.416C>G	c.(415-417)GCA>GGA	p.A139G	RGS1_uc010pou.1_Missense_Mutation_p.A139G	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	139	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				ATATATAAAGCATTTGTGCAT	0.343													G	192547487	G	G	192547487	3	3	12	1	0	0	0	0	1	0	0	0	13292	710	25	5	430	5	RGS1	1	192547487	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	31504413	192547487	56703134	11	835											
SRD5A2	6716	broad.mit.edu	37	chr2	31756490	31756490	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcttcctgagctggcgcaaTatatagtcactatgaatgtt	10	8	1	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr2:31756490T>C	uc002rnw.1	-	4	569	c.498A>G	c.(496-498)ATA>ATG	p.I166M		NM_000348	NP_000339	P31213	S5A2_HUMAN	3-oxo-5 alpha-steroid 4-dehydrogenase 2	166	Helical; (Potential).				androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity				0	Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GCTGGCGCAATATATAGTCAC	0.433													C	31756490	C	C	31756490	3	2	12	1	0	0	0	0	1	0	0	0	15138	1396	49	4	278	4	SRD5A2	2	31756490	Missense_Mutation	SNP	T	TCGA-06-0126-01A-01D-1490-08		31756490	211442883	12	836											
TTN	7273	broad.mit.edu	37	chr2	179452825	179452825	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gcatctgctatttttggtctCatttccacaacatatccaat	4	11	2	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr2:179452825C>A	uc010zfg.1	-	254	55829	c.55605G>T	c.(55603-55605)ATG>ATT	p.M18535I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.M12230I|TTN_uc010zfi.1_Missense_Mutation_p.M12163I|TTN_uc010zfj.1_Missense_Mutation_p.M12038I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19462							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTGGTCTCATTTCCACAA	0.453													A	179452825	A	A	179452825	3	1	12	1	0	0	0	0	1	0	0	0	16732	826	29	5	44902	5	TTN	2	179452825	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	147696335	179452825	63746548	13	837											
CNTN4	152330	broad.mit.edu	37	chr3	3078881	3078881	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agtcccagaactcattgatgGgaagacattcacagcgaccg	10	11	2	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr3:3078881G>T	uc003bpc.2	+	17	2182	c.1961G>T	c.(1960-1962)GGG>GTG	p.G654V	CNTN4_uc003bpb.1_Missense_Mutation_p.G325V|CNTN4_uc003bpd.1_Missense_Mutation_p.G654V|CNTN4_uc003bpe.2_Missense_Mutation_p.G326V|CNTN4_uc003bpf.2_Missense_Mutation_p.G325V|CNTN4_uc003bpg.2_5'Flank	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	654	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CTCATTGATGGGAAGACATTC	0.483													T	3078881	T	T	3078881	3	4	12	1	0	0	0	0	1	0	0	0	3643	1232	43	5	2019	5	CNTN4	3	3078881	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08		3078881	194943549	14	838											
ABCC5	10057	broad.mit.edu	37	chr3	183665250	183665250	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagccaccgcatcgcacaCgtaaacaaaaaaaaaggagc	8	13	0	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr3:183665250C>T	uc003fmg.2	-	23	3441	c.3276G>A	c.(3274-3276)ACG>ACA	p.T1092T	ABCC5_uc011bqt.1_Silent_p.T620T|ABCC5_uc010hxl.2_Silent_p.T1049T	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1092	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCATCGCACACGTAAACAAAA	0.532													T	183665250	T	T	183665250	2	4	12	1	0	0	0	0	0	0	0	1	56	523	19	1		1	ABCC5	3	183665250	Silent	SNP	C	TCGA-06-0126-01A-01D-1490-08	180586369	183665250	14357180	15	839											
ADRA2C	152	broad.mit.edu	37	chr4	3768581	3768581	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgaccagccgggcgctgcGcgcgccacagaacctcttcc	12	18	1	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr4:3768581G>A	uc003ghm.2	+	1	286	c.248G>A	c.(247-249)CGC>CAC	p.R83H	ADRA2C_uc010icx.2_Missense_Mutation_p.R83H	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	83	Cytoplasmic (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CGGGCGCTGCGCGCGCCACAG	0.677													A	3768581	A	A	3768581	3	1	12	1	0	0	0	0	1	0	0	0	339	1087	38	1	250	1	ADRA2C	4	3768581	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08		3768581	187385695	16	840											
UGT2B28	54490	broad.mit.edu	37	chr4	70148376	70148376	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caaacctgccaaacccctacCtaaggtaaacatactttcgt	4	14	0	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr4:70148376C>A	uc003hej.2	+	2	868	c.866C>A	c.(865-867)CCT>CAT	p.P289H	UGT2B28_uc010ihr.2_Missense_Mutation_p.P289H	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	289					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	AAACCCCTACCTAAGGTAAAC	0.383													A	70148376	A	A	70148376	3	1	12	1	0	0	0	0	1	0	0	0	16957	681	24	5	872	5	UGT2B28	4	70148376	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	66379795	70148376	121005900	17	841											
FGB	2244	broad.mit.edu	37	chr4	155490927	155490927	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caacggcatgttcttcagcaCgtatgacagagacaatgacg	10	10	2	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr4:155490927C>T	uc003ioa.3	+	7	1259	c.1220C>T	c.(1219-1221)ACG>ATG	p.T407M	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.T345M|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.T188M	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	407	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TTCTTCAGCACGTATGACAGA	0.423													T	155490927	T	T	155490927	3	4	12	1	0	0	0	0	1	0	0	0	5831	536	19	1	1246	1	FGB	4	155490927	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	85342551	155490927	35663349	18	842											
GRIA2	2891	broad.mit.edu	37	chr4	158234012	158234012	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgaaagggataaagtaaaCgacattgtagaccaggtttg	12	4	0	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr4:158234012C>T	uc003ipm.3	+	4	1110	c.651C>T	c.(649-651)AAC>AAT	p.N217N	GRIA2_uc011cit.1_Silent_p.N170N|GRIA2_uc003ipl.3_Silent_p.N217N|GRIA2_uc003ipk.3_Silent_p.N170N|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	217	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.N217N(1)		central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	ATAAAGTAAACGACATTGTAG	0.373													T	158234012	T	T	158234012	2	4	12	1	0	0	0	0	0	0	0	1	6768	535	19	1		1	GRIA2	4	158234012	Silent	SNP	C	TCGA-06-0126-01A-01D-1490-08	2743085	158234012	32920264	19	843											
RAPGEF2	9693	broad.mit.edu	37	chr4	160251077	160251077	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agaaaagaacatgcaaaaagTtgaagaggaaggagagattg	13	2	0	5			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr4:160251077T>G	uc003iqg.3	+	6	1044	c.734T>G	c.(733-735)GTT>GGT	p.V245G		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	245	cNMP.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		ATGCAAAAAGTTGAAGAGGAA	0.398													G	160251077	G	G	160251077	3	3	12	1	0	0	0	0	1	0	0	0	13044	1725	60	5	756	5	RAPGEF2	4	160251077	Missense_Mutation	SNP	T	TCGA-06-0126-01A-01D-1490-08	2017065	160251077	30903199	20	844											
SORBS2	8470	broad.mit.edu	37	chr4	186545050	186545050	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgaattcggagatgcgtgtGggcaccatgtcccggggcac	15	11	0	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr4:186545050G>A	uc003iyl.2	-	13	2379	c.1521C>T	c.(1519-1521)CCC>CCT	p.P507P	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Silent_p.P607P|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Silent_p.P411P|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Silent_p.P621P|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	507						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		AGATGCGTGTGGGCACCATGT	0.572													A	186545050	A	A	186545050	2	1	12	1	0	0	0	0	0	0	0	1	14928	1335	47	3		3	SORBS2	4	186545050	Silent	SNP	G	TCGA-06-0126-01A-01D-1490-08	26293973	186545050	4609226	21	845											
DNAH5	1767	broad.mit.edu	37	chr5	13916467	13916467	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgcacttacctttacaaacAgagatgtgatcttctcagag	7	9	2	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr5:13916467A>G	uc003jfd.2	-	9	1229	c.1187T>C	c.(1186-1188)CTG>CCG	p.L396P	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	396	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTTACAAACAGAGATGTGAT	0.323									Kartagener_syndrome				G	13916467	G	G	13916467	3	3	12	1	0	0	0	0	1	0	0	0	4604	188	7	4	12971	4	DNAH5	5	13916467	Missense_Mutation	SNP	A	TCGA-06-0126-01A-01D-1490-08		13916467	166998793	22	846											
HEATR7B2	133558	broad.mit.edu	37	chr5	41049516	41049516	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	attctgcaggtaccacaaaaGtcaggatccttggccatagc	9	11	2	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr5:41049516G>T	uc003jmj.3	-	14	1857	c.1367C>A	c.(1366-1368)ACT>AAT	p.T456N	HEATR7B2_uc003jmi.3_Missense_Mutation_p.T11N	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	456							binding	p.T456N(1)		ovary(6)|central_nervous_system(2)	8						TACCACAAAAGTCAGGATCCT	0.458													T	41049516	T	T	41049516	3	4	12	1	0	0	0	0	1	0	0	0	7035	1029	36	5	3506	5	HEATR7B2	5	41049516	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08	27133049	41049516	139865744	23	847											
OR2Y1	134083	broad.mit.edu	37	chr5	180166818	180166818	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgcaaaggttgatcaggaGctggggcacggtgctggtgg	18	9	1	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr5:180166818G>A	uc003mmf.1	-	1	241	c.241C>T	c.(241-243)CTC>TTC	p.L81F		NM_001001657	NP_001001657	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGATCAGGAGCTGGGGCACG	0.587													A	180166818	A	A	180166818	3	1	12	1	0	0	0	0	1	0	0	0	11035	971	34	3	698	3	OR2Y1	5	180166818	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08	139117302	180166818	748442	24	848											
SNRNP48	154007	broad.mit.edu	37	chr6	7602909	7602909	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aaatcctggcagaagtacgaGattataaaagaagacgccag	10	7	0	4			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr6:7602909G>T	uc003mxr.2	+	6	708	c.649G>T	c.(649-651)GAT>TAT	p.D217Y	SNRNP48_uc003mxs.2_RNA|SNRNP48_uc003mxt.1_5'UTR	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	217					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						AGAAGTACGAGATTATAAAAG	0.308													T	7602909	T	T	7602909	3	4	12	1	0	0	0	0	1	0	0	0	14857	942	33	5	671	5	SNRNP48	6	7602909	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08		7602909	163512158	25	849											
LGSN	51557	broad.mit.edu	37	chr6	63990671	63990671	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatttccatctgaccaggcCtggtagaggaggaaaaactc	11	9	1	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr6:63990671C>T	uc003peh.2	-	4	819	c.785G>A	c.(784-786)AGG>AAG	p.R262K	LGSN_uc003pei.2_Intron	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	262					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	CTGACCAGGCCTGGTAGAGGA	0.433													T	63990671	T	T	63990671	3	4	12	1	0	0	0	0	1	0	0	0	8759	681	24	3	748	3	LGSN	6	63990671	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	56387762	63990671	107124396	26	850											
C6orf97	80129	broad.mit.edu	37	chr6	151914390	151914390	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagtcattgagaacaagaCcattgcccacaatttgcaga	8	10	1	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr6:151914390C>T	uc003qol.2	+	8	1531	c.1442C>T	c.(1441-1443)ACC>ATC	p.T481I		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	481	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		GAGAACAAGACCATTGCCCAC	0.423													T	151914390	T	T	151914390	3	4	12	1	0	0	0	0	1	0	0	0	2374	507	18	3	1472	3	C6orf97	6	151914390	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	87923719	151914390	19200677	27	851											
KLHL7	55975	broad.mit.edu	37	chr7	23163411	23163411	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attagaaaacgttgtgtgacGtgatcctcatggtccaggaa	11	7	1	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr7:23163411G>A	uc003svs.3	+	2	429	c.136G>A	c.(136-138)GTG>ATG	p.V46M	KLHL7_uc003svr.3_Missense_Mutation_p.V24M|KLHL7_uc011jys.1_Intron|KLHL7_uc011jyt.1_Intron|KLHL7_uc003svt.2_Translation_Start_Site|KLHL7_uc003svp.2_Missense_Mutation_p.V24M|KLHL7_uc003svq.2_Missense_Mutation_p.V46M|KLHL7_uc011jyu.1_Missense_Mutation_p.V24M	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	46	BTB.					Golgi apparatus|nucleolus|plasma membrane					0						GTTGTGTGACGTGATCCTCAT	0.373													A	23163411	A	A	23163411	3	1	12	1	0	0	0	0	1	0	0	0	8394	1145	40	1	142	1	KLHL7	7	23163411	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08		23163411	135975252	28	852											
MRPL32	64983	broad.mit.edu	37	chr7	42977165	42977165	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagcgaccatcctggttcaCccagaattgacaccaaagat	7	12	1	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr7:42977165C>T	uc003tia.2	+	3	604	c.557C>T	c.(556-558)ACC>ATC	p.T186I	MRPL32_uc003tib.2_RNA|MRPL32_uc003tic.2_Missense_Mutation_p.T133I	NM_031903	NP_114109	Q9BYC8	RM32_HUMAN	mitochondrial ribosomal protein L32 precursor	186					translation	large ribosomal subunit|mitochondrial ribosome	structural constituent of ribosome				0						TCCTGGTTCACCCAGAATTGA	0.418													T	42977165	T	T	42977165	3	4	12	1	0	0	0	0	1	0	0	0	9795	507	18	3	567	3	MRPL32	7	42977165	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	19813754	42977165	116161498	29	853											
WBSCR17	64409	broad.mit.edu	37	chr7	70886068	70886068	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaaagactggtgggacgcCggagacccttctctccccat	10	15	1	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr7:70886068C>T	uc003tvy.2	+	5	939	c.939C>T	c.(937-939)GCC>GCT	p.A313A	WBSCR17_uc003tvz.2_Silent_p.A12A	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	313	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGTGGGACGCCGGAGACCCTT	0.597													T	70886068	T	T	70886068	2	4	12	1	0	0	0	0	0	0	0	1	17261	639	23	2		2	WBSCR17	7	70886068	Silent	SNP	C	TCGA-06-0126-01A-01D-1490-08	27908903	70886068	88252595	30	854											
GRM3	2913	broad.mit.edu	37	chr7	86468552	86468552	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactacatcaggtgggaagaCgcctgggccattggcccagt	14	11	1	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr7:86468552C>T	uc003uid.2	+	4	2821	c.1722C>T	c.(1720-1722)GAC>GAT	p.D574D	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Silent_p.D446D|GRM3_uc010leh.2_Silent_p.D166D	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	574	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGTGGGAAGACGCCTGGGCCA	0.498													T	86468552	T	T	86468552	2	4	12	1	0	0	0	0	0	0	0	1	6798	535	19	1		1	GRM3	7	86468552	Silent	SNP	C	TCGA-06-0126-01A-01D-1490-08	15582484	86468552	72670111	31	855											
COL1A2	1278	broad.mit.edu	37	chr7	94054953	94054953	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacgatggtcccccaggtcGcgatggtcaacccggacaca	12	14	1	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr7:94054953G>A	uc003ung.1	+	43	3284	c.2813G>A	c.(2812-2814)CGC>CAC	p.R938H	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	938					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging	p.R938H(1)	COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCCCCAGGTCGCGATGGTCAA	0.488										HNSCC(75;0.22)			A	94054953	A	A	94054953	3	1	12	1	0	0	0	0	1	0	0	0	3678	1087	38	1	2983	1	COL1A2	7	94054953	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08	7586401	94054953	65083710	32	856											
FZD6	8323	broad.mit.edu	37	chr8	104342147	104342147	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaatgagagaggtgaaagcGgacggagctagcacccccag	14	10	1	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr8:104342147G>A	uc003ylh.2	+	6	2090	c.1806G>A	c.(1804-1806)GCG>GCA	p.A602A	FZD6_uc003ylj.2_Silent_p.A602A|FZD6_uc011lhn.1_Silent_p.A568A|FZD6_uc011lho.1_Silent_p.A297A|FZD6_uc011lhp.1_Silent_p.A547A	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	602	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			AGGTGAAAGCGGACGGAGCTA	0.512													A	104342147	A	A	104342147	2	1	12	1	0	0	0	0	0	0	0	1	6134	1103	39	2		2	FZD6	8	104342147	Silent	SNP	G	TCGA-06-0126-01A-01D-1490-08		104342147	42021875	33	857											
C8orf76	84933	broad.mit.edu	37	chr8	124243741	124243743	+	In_Frame_Del	DEL	AAG	-	-													agtcttttcctgagtgtggaAagaaggatttgatagttttg							TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr8:124243741_124243743delAAG	uc003yqc.1	-	4	643_645	c.612_614delCTT	c.(610-615)TTCTTT>TTT	p.204_205FF>F	C8orf76_uc003yqd.2_In_Frame_Del_p.172_173FF>F	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	204_205							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGAGTGTGGAAAGAAGGATTTGA	0.433													-	124243743	-	-	124243741	7	5	12	1	0	1	0	1	0	0	0	0	2437	14	1	0	540	0	C8orf76	8	124243741	In_Frame_Del	DEL	AAG	TCGA-06-0126-01A-01D-1490-08	19901594	124243741	22120281	34	858											
EPPK1	83481	broad.mit.edu	37	chr8	144940328	144940328	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcctcgtcgaagtagccgCgccggtaggccacgtccacg	12	16	1	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr8:144940328C>T	uc003zaa.1	-	2	15117	c.15104G>A	c.(15103-15105)CGC>CAC	p.R5035H		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5035	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAAGTAGCCGCGCCGGTAGGC	0.692													T	144940328	T	T	144940328	3	4	12	1	0	0	0	0	1	0	0	0	5190	768	27	1	172	1	EPPK1	8	144940328	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	20696587	144940328	1423694	35	859											
TEK	7010	broad.mit.edu	37	chr9	27158007	27158007	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccgctggaagttactcaagaTgtgaccagagaatgggctaa	12	8	1	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr9:27158007T>A	uc003zqi.3	+	2	673	c.231T>A	c.(229-231)GAT>GAA	p.D77E	TEK_uc010mjc.1_Intron|TEK_uc011lnn.1_Missense_Mutation_p.D77E|TEK_uc011lno.1_Missense_Mutation_p.D77E|TEK_uc011lnp.1_Intron|TEK_uc003zqj.1_Missense_Mutation_p.D54E	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	77	Extracellular (Potential).|Ig-like C2-type 1.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.D77E(1)		ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TTACTCAAGATGTGACCAGAG	0.493													A	27158007	A	A	27158007	3	1	12	1	0	0	0	0	1	0	0	0	15748	1461	51	5	237	5	TEK	9	27158007	Missense_Mutation	SNP	T	TCGA-06-0126-01A-01D-1490-08		27158007	114055424	36	860											
TGFBR1	7046	broad.mit.edu	37	chr9	101908855	101908855	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatctatgcaatgggcttaGtattctgggaaattgctcga	10	7	2	0	rs146549837		TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr9:101908855G>A	uc004azc.2	+	7	1295	c.1219G>A	c.(1219-1221)GTA>ATA	p.V407I	TGFBR1_uc004azd.2_Missense_Mutation_p.V330I|TGFBR1_uc011lvc.1_Missense_Mutation_p.V338I	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	407	Protein kinase.|Cytoplasmic (Potential).				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				AATGGGCTTAGTATTCTGGGA	0.398													A	101908855	A	A	101908855	3	1	12	1	0	0	0	0	1	0	0	0	15818	1029	36	3	1245	3	TGFBR1	9	101908855	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08	74750848	101908855	39304576	37	861											
ORM2	5005	broad.mit.edu	37	chr9	117092750	117092750	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tttatatcgcatcggcctttCgaaacgaggagtacaataag	9	8	0	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr9:117092750C>A	uc004bil.2	+	2	267	c.151C>A	c.(151-153)CGA>AGA	p.R51R	ORM1_uc011lxo.1_Intron	NM_000608	NP_000599	P19652	A1AG2_HUMAN	orosomucoid 2 precursor	51					acute-phase response|regulation of immune system process|transport	extracellular space	binding				0		Myeloproliferative disorder(63;0.163)				ATCGGCCTTTCGAAACGAGGA	0.438													A	117092750	A	A	117092750	2	1	12	1	0	0	0	0	0	0	0	1	11268	876	31	5		5	ORM2	9	117092750	Silent	SNP	C	TCGA-06-0126-01A-01D-1490-08	15183895	117092750	24120681	38	862											
THNSL1	79896	broad.mit.edu	37	chr10	25313145	25313145	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaaaaattgctcctgtcagGcacctttcaggcaaccagtt	7	12	3	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr10:25313145G>A	uc001isi.3	+	3	1322	c.993G>A	c.(991-993)AGG>AGA	p.R331R	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	331					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	CTCCTGTCAGGCACCTTTCAG	0.433													A	25313145	A	A	25313145	2	1	12	1	0	0	0	0	0	0	0	1	15859	1194	42	3		3	THNSL1	10	25313145	Silent	SNP	G	TCGA-06-0126-01A-01D-1490-08		25313145	110221602	39	863											
CNNM2	54805	broad.mit.edu	37	chr10	104836896	104836896	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aacagaactgtgtgacgcacAgtaaggccaaccacagcctg	10	12	0	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr10:104836896A>T	uc001kwm.2	+	8	2711	c.2587A>T	c.(2587-2589)AGT>TGT	p.S863C	CNNM2_uc001kwn.2_Missense_Mutation_p.S841C	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	863					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		TGTGACGCACAGTAAGGCCAA	0.617													T	104836896	T	T	104836896	3	4	12	1	0	0	0	0	1	0	0	0	3613	188	7	5	2659	5	CNNM2	10	104836896	Missense_Mutation	SNP	A	TCGA-06-0126-01A-01D-1490-08	79523751	104836896	30697851	40	864											
SMC3	9126	broad.mit.edu	37	chr10	112350834	112350834	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaatcttcctggagaggttActtttctgcctcttaacaag	8	9	3	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr10:112350834A>G	uc001kze.2	+	17	1882	c.1756A>G	c.(1756-1758)ACT>GCT	p.T586A		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	586	Flexible hinge.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TGGAGAGGTTACTTTTCTGCC	0.328													G	112350834	G	G	112350834	3	3	12	1	0	0	0	0	1	0	0	0	14784	391	14	4	1822	4	SMC3	10	112350834	Missense_Mutation	SNP	A	TCGA-06-0126-01A-01D-1490-08	7513938	112350834	23183913	41	865											
RAG2	5897	broad.mit.edu	37	chr11	36614899	36614899	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttcaagctgatagccaccaaCaataacaaattcatcattgt	4	10	3	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr11:36614899C>A	uc001mwv.3	-	2	1008	c.820G>T	c.(820-822)GTT>TTT	p.V274F	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	274					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TAGCCACCAACAATAACAAAT	0.428									Familial_Hemophagocytic_Lymphohistiocytosis				A	36614899	A	A	36614899	3	1	12	1	0	0	0	0	1	0	0	0	13005	478	17	5	767	5	RAG2	11	36614899	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08		36614899	98391617	42	866											
PPME1	51400	broad.mit.edu	37	chr11	73964552	73964552	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacagtgtgtttcctggctgTtagtgacctgctgtccaccc	10	13	0	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr11:73964552T>C	uc001ouw.2	+	14	1257	c.1158T>C	c.(1156-1158)TGT>TGC	p.C386C	PPME1_uc009yty.2_Silent_p.C270C|PPME1_uc001oux.2_Silent_p.C199C|P4HA3_uc001ouy.3_Intron	NM_016147	NP_057231	Q9Y570	PPME1_HUMAN	protein phosphatase methylesterase 1	386					protein demethylation		carboxylesterase activity|protein C-terminal methylesterase activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0	Breast(11;3.29e-05)					TTCCTGGCTGTTAGTGACCTG	0.498													C	73964552	C	C	73964552	2	2	12	1	0	0	0	0	0	0	0	1	12347	1731	60	4		4	PPME1	11	73964552	Silent	SNP	T	TCGA-06-0126-01A-01D-1490-08	37349653	73964552	61041964	43	867											
HMBS	3145	broad.mit.edu	37	chr11	118962836	118962836	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccctgttccgcctccacagaTcctgcaccctgaggaatgca	8	17	0	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr11:118962836T>G	uc001puz.1	+	10	771	c.614T>G	c.(613-615)ATC>AGC	p.I205S	HMBS_uc009zao.1_Missense_Mutation_p.I150S|HMBS_uc001pvc.1_Missense_Mutation_p.I150S|HMBS_uc009zap.1_Missense_Mutation_p.I188S|HMBS_uc001pva.1_Missense_Mutation_p.I205S|HMBS_uc001pvb.1_Intron|HMBS_uc001pvd.1_Missense_Mutation_p.I188S|HMBS_uc001pve.1_Missense_Mutation_p.I188S|HMBS_uc001pvf.1_Missense_Mutation_p.I188S	NM_000190	NP_000181	P08397	HEM3_HUMAN	hydroxymethylbilane synthase isoform 1	205					peptidyl-pyrromethane cofactor linkage	cytosol	hydroxymethylbilane synthase activity				0	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		CCTCCACAGATCCTGCACCCT	0.537									Porphyria_Acute_Intermittent				G	118962836	G	G	118962836	3	3	12	1	0	0	0	0	1	0	0	0	7219	1449	50	5	652	5	HMBS	11	118962836	Missense_Mutation	SNP	T	TCGA-06-0126-01A-01D-1490-08	44998284	118962836	16043680	44	868											
ANO2	57101	broad.mit.edu	37	chr12	5963280	5963280	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgccacggggcgtgtatccGgacaaagatggatccctggc	14	12	0	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr12:5963280G>A	uc001qnm.2	-	4	622	c.550C>T	c.(550-552)CGG>TGG	p.R184W		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	188	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						GCGTGTATCCGGACAAAGATG	0.458													A	5963280	A	A	5963280	3	1	12	1	0	0	0	0	1	0	0	0	697	1115	39	2	2538	2	ANO2	12	5963280	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08		5963280	127888615	45	869											
LUM	4060	broad.mit.edu	37	chr12	91497971	91497971	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgacttcgttagcaacacGtagacattcatacatatccg	7	10	1	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr12:91497971G>A	uc001tbm.2	-	3	1377	c.988C>T	c.(988-990)CGT>TGT	p.R330C	LUM_uc001tbn.2_RNA	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	330					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						TTAGCAACACGTAGACATTCA	0.383													A	91497971	A	A	91497971	3	1	12	1	0	0	0	0	1	0	0	0	9085	1145	40	1	32	1	LUM	12	91497971	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08	85534691	91497971	42353924	46	870											
DAO	1610	broad.mit.edu	37	chr12	109288048	109288048	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gttgctaccaggtggcaagaGaaggcgcagacgtgattgtc	15	8	0	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr12:109288048G>A	uc001tnr.3	+	7	670	c.517G>A	c.(517-519)GAA>AAA	p.E173K	DAO_uc001tnq.3_Missense_Mutation_p.E107K|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	173					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2						GGTGGCAAGAGAAGGCGCAGA	0.582													A	109288048	A	A	109288048	3	1	12	1	0	0	0	0	1	0	0	0	4231	943	33	3	539	3	DAO	12	109288048	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08	17790077	109288048	24563847	47	871											
PCDH9	5101	broad.mit.edu	37	chr13	67800099	67800099	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgaagatcacaacaatgaccAccatggcaccggcgatgatg	10	12	1	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr13:67800099A>T	uc001vik.2	-	2	3166	c.2474T>A	c.(2473-2475)GTG>GAG	p.V825E	PCDH9_uc001vil.2_Missense_Mutation_p.V825E|PCDH9_uc010thl.1_Missense_Mutation_p.V825E|PCDH9_uc001vin.3_Missense_Mutation_p.V825E	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	825	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		AACAATGACCACCATGGCACC	0.517													T	67800099	T	T	67800099	3	4	12	1	0	0	0	0	1	0	0	0	11518	159	6	5	1255	5	PCDH9	13	67800099	Missense_Mutation	SNP	A	TCGA-06-0126-01A-01D-1490-08		67800099	47369779	48	872											
OR4N5	390437	broad.mit.edu	37	chr14	20612258	20612258	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgttgtgatggcctttgacCgctacatcgccatctgccgg	11	13	1	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr14:20612258C>T	uc010tla.1	+	1	364	c.364C>T	c.(364-366)CGC>TGC	p.R122C		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GGCCTTTGACCGCTACATCGC	0.483													T	20612258	T	T	20612258	3	4	12	1	0	0	0	0	1	0	0	0	11079	652	23	2	366	2	OR4N5	14	20612258	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08		20612258	86737282	49	873											
CDCA4	55038	broad.mit.edu	37	chr14	105477589	105477589	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtccagctcgcccaggtcGgacttgcagctggagctagg	15	12	0	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr14:105477589G>A	uc001yqa.2	-	2	774	c.678C>T	c.(676-678)TCC>TCT	p.S226S	CDCA4_uc001yqb.2_Silent_p.S226S	NM_145701	NP_663747	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	226						nucleus				ovary(1)	1		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		CGCCCAGGTCGGACTTGCAGC	0.672													A	105477589	A	A	105477589	2	1	12	1	0	0	0	0	0	0	0	1	3088	1103	39	2		2	CDCA4	14	105477589	Silent	SNP	G	TCGA-06-0126-01A-01D-1490-08	84865331	105477589	1871951	50	874											
RYR3	6263	broad.mit.edu	37	chr15	34130001	34130002	+	Frame_Shift_Ins	INS	-	A	A													atggtaaaggaattatctccINSaaaaaagaattccagaaggc							TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr15:34130001_34130002insA	uc001zhi.2	+	89	11890_11891	c.11820_11821insA	c.(11818-11823)TCCAAAfs	p.S3940fs	RYR3_uc010bar.2_Frame_Shift_Ins_p.S3935fs	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3940_3941	EF-hand.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAATTATCTCCAAAAAAGAATT	0.391													A	34130002	A	A	34130001	7	5	12	1	0	1	1	0	0	0	0	0	13770	581	21	0	12174	0	RYR3	15	34130001	Frame_Shift_Ins	INS	-	TCGA-06-0126-01A-01D-1490-08		34130001	68401391	51	875											
EIF2AK4	440275	broad.mit.edu	37	chr15	40282488	40282488	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacagggaatgattcaccgGgatttgaagcctgtcaacat	10	9	2	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr15:40282488G>A	uc001zkm.1	+	16	2591	c.2541G>A	c.(2539-2541)CGG>CGA	p.R847R	EIF2AK4_uc010bbj.1_Silent_p.R548R|EIF2AK4_uc001zkn.1_5'Flank	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	847	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TGATTCACCGGGATTTGAAGC	0.378													A	40282488	A	A	40282488	2	1	12	1	0	0	0	0	0	0	0	1	4999	1219	43	3		3	EIF2AK4	15	40282488	Silent	SNP	G	TCGA-06-0126-01A-01D-1490-08	6152487	40282488	62248904	52	876											
NEDD4	4734	broad.mit.edu	37	chr15	56208834	56208834	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatctttcttgagactgaaCgttttcctttattaacggag	8	7	2	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr15:56208834C>T	uc002adj.2	-	1	496	c.196G>A	c.(196-198)GTT>ATT	p.V66I	NEDD4_uc002adl.2_Intron|NEDD4_uc002adi.2_Missense_Mutation_p.V66I|NEDD4_uc010ugj.1_Missense_Mutation_p.V66I|NEDD4_uc010bfm.2_Missense_Mutation_p.V66I|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	66					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		TGAGACTGAACGTTTTCCTTT	0.408													T	56208834	T	T	56208834	3	4	12	1	0	0	0	0	1	0	0	0	10310	536	19	1	3863	1	NEDD4	15	56208834	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	15926346	56208834	46322558	53	877											
SCNN1G	6340	broad.mit.edu	37	chr16	23226531	23226531	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctctatcattgcccgccGccagtggcagaaagccaagg	10	14	2	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr16:23226531G>A	uc002dlm.1	+	13	1830	c.1691G>A	c.(1690-1692)CGC>CAC	p.R564H		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	564	Cytoplasmic (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	ATTGCCCGCCGCCAGTGGCAG	0.587													A	23226531	A	A	23226531	3	1	12	1	0	0	0	0	1	0	0	0	13930	1087	38	1	1737	1	SCNN1G	16	23226531	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08		23226531	67128222	54	878											
CHD9	80205	broad.mit.edu	37	chr16	53289572	53289572	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaagaggtgcttatggtgctAttatggaggaagaagatgaa	15	2	0	4			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr16:53289572A>G	uc002ehb.2	+	18	4254	c.4090A>G	c.(4090-4092)ATT>GTT	p.I1364V	CHD9_uc002egy.2_Missense_Mutation_p.I1364V|CHD9_uc002ehc.2_Missense_Mutation_p.I1364V|CHD9_uc002ehf.2_Missense_Mutation_p.I478V|CHD9_uc002ehd.2_Missense_Mutation_p.I890V	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1364					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TTATGGTGCTATTATGGAGGA	0.348													G	53289572	G	G	53289572	3	3	12	1	0	0	0	0	1	0	0	0	3332	449	16	4	4160	4	CHD9	16	53289572	Missense_Mutation	SNP	A	TCGA-06-0126-01A-01D-1490-08	30063041	53289572	37065181	55	879											
CDH16	1014	broad.mit.edu	37	chr16	66946751	66946751	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acgtgggaattgggggagccGggggcatctgcatcctctgc	17	10	2	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr16:66946751G>T	uc002eql.2	-	10	1171	c.1098C>A	c.(1096-1098)CCC>CCA	p.P366P	CDH16_uc010cdy.2_Silent_p.P366P|CDH16_uc002eqm.2_Silent_p.P269P	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	366	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TGGGGGAGCCGGGGGCATCTG	0.612													T	66946751	T	T	66946751	2	4	12	1	0	0	0	0	0	0	0	1	3101	1103	39	5		5	CDH16	16	66946751	Silent	SNP	G	TCGA-06-0126-01A-01D-1490-08	13657179	66946751	23408002	56	880											
PLCG2	5336	broad.mit.edu	37	chr16	81968079	81968079	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agaaccagtccatcgccatcGagctctctgacctggttgtc	9	14	1	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr16:81968079G>A	uc002fgt.2	+	26	2937	c.2785G>A	c.(2785-2787)GAG>AAG	p.E929K		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	929					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						CATCGCCATCGAGCTCTCTGA	0.478													A	81968079	A	A	81968079	3	1	12	1	0	0	0	0	1	0	0	0	12036	1059	37	2	2883	2	PLCG2	16	81968079	Missense_Mutation	SNP	G	TCGA-06-0126-01A-01D-1490-08	15021328	81968079	8386674	57	881											
HEXIM2	124790	broad.mit.edu	37	chr17	43246862	43246862	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggacagtgatgggcggggcCgagcgcacggtgagttccag	20	9	0	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr17:43246862C>T	uc002iih.1	+	4	786	c.547C>T	c.(547-549)CGA>TGA	p.R183*	HEXIM2_uc010daf.1_Nonsense_Mutation_p.R205*|HEXIM2_uc002iii.1_Nonsense_Mutation_p.R183*|HEXIM2_uc002iij.1_Nonsense_Mutation_p.R183*|uc002iik.1_RNA	NM_144608	NP_653209	Q96MH2	HEXI2_HUMAN	hexamthylene bis-acetamide inducible 2	183					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding				0						TGGGCGGGGCCGAGCGCACGG	0.647													T	43246862	T	T	43246862	4	4	12	1	0	0	0	0	0	1	0	0	7077	644	23	2	553	2	HEXIM2	17	43246862	Nonsense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08		43246862	37948348	58	882											
TEX2	55852	broad.mit.edu	37	chr17	62272375	62272375	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaaagtcttaaggttccaccCtcaagtcgaacaaagactga	8	10	2	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr17:62272375C>A	uc002jec.2	-	3	1898	c.1725G>T	c.(1723-1725)GAG>GAT	p.E575D	TEX2_uc002jed.2_Missense_Mutation_p.E575D|TEX2_uc002jee.2_Missense_Mutation_p.E575D	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	575					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AGGTTCCACCCTCAAGTCGAA	0.423													A	62272375	A	A	62272375	3	1	12	1	0	0	0	0	1	0	0	0	15778	680	24	5	1719	5	TEX2	17	62272375	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	19025513	62272375	18922835	59	883											
MUC16	94025	broad.mit.edu	37	chr19	9085127	9085127	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tacatctgatgctactgtggAcaagccaggtggacctgcgc	12	11	1	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr19:9085127A>G	uc002mkp.2	-	1	6892	c.6688T>C	c.(6688-6690)TCC>CCC	p.S2230P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2230	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTACTGTGGACAAGCCAGGT	0.488													G	9085127	G	G	9085127	3	3	12	1	0	0	0	0	1	0	0	0	9973	275	10	4	37171	4	MUC16	19	9085127	Missense_Mutation	SNP	A	TCGA-06-0126-01A-01D-1490-08		9085127	50043856	60	884											
OR7G2	390882	broad.mit.edu	37	chr19	9213088	9213088	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catttgagggaacacagaatAcatcactgaagccactgcag	9	10	1	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr19:9213088A>T	uc010xkk.1	-	1	895	c.895T>A	c.(895-897)TAT>AAT	p.Y299N		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AACACAGAATACATCACTGAA	0.453													T	9213088	T	T	9213088	3	4	12	1	0	0	0	0	1	0	0	0	11223	391	14	5	144	5	OR7G2	19	9213088	Missense_Mutation	SNP	A	TCGA-06-0126-01A-01D-1490-08	127961	9213088	49915895	61	885											
PKN1	5585	broad.mit.edu	37	chr19	14574778	14574778	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggatccgaggcccggaccaCggggtaaggaaggagggccc	18	11	0	0			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr19:14574778C>T	uc002myp.2	+	11	1802	c.1634C>T	c.(1633-1635)ACG>ATG	p.T545M	PKN1_uc002myq.2_Missense_Mutation_p.T551M	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	545					activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						GCCCGGACCACGGGGTAAGGA	0.672													T	14574778	T	T	14574778	3	4	12	1	0	0	0	0	1	0	0	0	11979	536	19	1	1719	1	PKN1	19	14574778	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08	5361690	14574778	44554205	62	886											
TMEM59L	25789	broad.mit.edu	37	chr19	18731283	18731283	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcccctgtacccgccgccGtcccacgcctgtgaggacag	12	18	0	1			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr19:18731283G>A	uc002njy.3	+	8	1053	c.966G>A	c.(964-966)CCG>CCA	p.P322P		NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	322						Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						ACCCGCCGCCGTCCCACGCCT	0.642													A	18731283	A	A	18731283	2	1	12	1	0	0	0	0	0	0	0	1	16183	1132	40	1		1	TMEM59L	19	18731283	Silent	SNP	G	TCGA-06-0126-01A-01D-1490-08	4156505	18731283	40397700	63	887											
ZNF135	7694	broad.mit.edu	37	chr19	58579144	58579144	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctgaccgagcatcggaggaTtcacacaggagagaagccct	12	12	1	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr19:58579144T>G	uc010yhq.1	+	5	1424	c.1328T>G	c.(1327-1329)ATT>AGT	p.I443S	ZNF135_uc002qre.2_Missense_Mutation_p.I431S|ZNF135_uc002qrd.1_Intron|ZNF135_uc002qrf.2_Missense_Mutation_p.I389S|ZNF135_uc002qrg.2_Missense_Mutation_p.I401S|ZNF135_uc010yhr.1_Missense_Mutation_p.I252S	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	443					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CATCGGAGGATTCACACAGGA	0.547													G	58579144	G	G	58579144	3	3	12	1	0	0	0	0	1	0	0	0	17722	1493	52	5	1495	5	ZNF135	19	58579144	Missense_Mutation	SNP	T	TCGA-06-0126-01A-01D-1490-08	39847861	58579144	549839	64	888											
ABCG1	9619	broad.mit.edu	37	chr21	43708133	43708133	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaacccttttctttggcacCggccctctgaagaggtaaag	10	11	2	3			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr21:43708133C>T	uc002zaq.2	+	9	1214	c.1108C>T	c.(1108-1110)CGG>TGG	p.R370W	ABCG1_uc002zan.2_Missense_Mutation_p.R372W|ABCG1_uc002zam.2_Missense_Mutation_p.R348W|ABCG1_uc002zao.2_Missense_Mutation_p.R367W|ABCG1_uc002zap.2_Missense_Mutation_p.R370W|ABCG1_uc002zar.2_Missense_Mutation_p.R381W|ABCG1_uc011aev.1_Missense_Mutation_p.R381W|ABCG1_uc010gpb.1_5'UTR	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	370	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	TCTTTGGCACCGGCCCTCTGA	0.577													T	43708133	T	T	43708133	3	4	12	1	0	0	0	0	1	0	0	0	68	643	23	2	1310	2	ABCG1	21	43708133	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08		43708133	4421762	65	889											
SREBF2	6721	broad.mit.edu	37	chr22	42276831	42276831	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctctcctggaacgtgatcCgctacagcctgcagaagcta	10	14	1	2			TCGA-06-0126-01A-01D-1490-08	TCGA-06-0126-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c3c3059d-e2fb-45ea-80b5-99fb040cba29	3f736ddc-4f66-45eb-98dc-0c8b68b790a0	g.chr22:42276831C>T	uc003bbi.2	+	10	2042	c.1873C>T	c.(1873-1875)CGC>TGC	p.R625C	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	625	Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						GAACGTGATCCGCTACAGCCT	0.647													T	42276831	T	T	42276831	3	4	12	1	0	0	0	0	1	0	0	0	15141	652	23	2	1911	2	SREBF2	22	42276831	Missense_Mutation	SNP	C	TCGA-06-0126-01A-01D-1490-08		42276831	9027735	66	890											
SLC45A1	50651	broad.mit.edu	37	chr1	8403928	8403928	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggggcccctgacctcggCcgtgggcagtgccaacgggg	17	15	0	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr1:8403928C>T	uc001apb.2	+	8	2102	c.2102C>T	c.(2101-2103)GCC>GTC	p.A701V	SLC45A1_uc001apc.2_Missense_Mutation_p.A399V	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	701	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity	p.A701V(1)		central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CTGACCTCGGCCGTGGGCAGT	0.617													T	8403928	T	T	8403928	3	4	13	1	0	0	0	0	1	0	0	0	14640	739	26	3	2132	3	SLC45A1	1	8403928	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08		8403928	240846693	1	891											
ZNF644	84146	broad.mit.edu	37	chr1	91405171	91405171	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atgtaggtagctgattttttGgatgatcctactacagagtc	10	6	0	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr1:91405171G>C	uc001dnw.2	-	3	1882	c.1740C>G	c.(1738-1740)TCC>TCG	p.S580S	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Silent_p.S580S	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		CTGATTTTTTGGATGATCCTA	0.383													C	91405171	C	C	91405171	2	2	13	1	0	0	0	0	0	0	0	1	18057	1335	47	5		5	ZNF644	1	91405171	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08	83001243	91405171	157845450	2	892											
ANKRD35	148741	broad.mit.edu	37	chr1	145558859	145558859	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgtacacccctgatgatcGcatcgctgggtgggcacgca	13	13	0	2	rs150752253	byFrequency	TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr1:145558859G>A	uc001eob.1	+	7	586	c.478G>A	c.(478-480)GCA>ACA	p.A160T	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.A3T	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	160	ANK 4.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CCTGATGATCGCATCGCTGGG	0.577													A	145558859	A	A	145558859	3	1	13	1	0	0	0	0	1	0	0	0	664	1087	38	1	504	1	ANKRD35	1	145558859	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	54153688	145558859	103691762	3	893											
SLC45A3	85414	broad.mit.edu	37	chr1	205632669	205632669	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagatgaagggccggcggcGgccatagcgtccacgccagt	15	14	0	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr1:205632669G>A	uc001hda.1	-	3	589	c.250C>T	c.(250-252)CGC>TGC	p.R84C	SLC45A3_uc010prn.1_5'Flank|SLC45A3_uc010pro.1_5'UTR|SLC45A3_uc010prp.1_Intron|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	84					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			GGCCGGCGGCGGCCATAGCGT	0.637			T	ETV1|ETV5|ELK4|ERG	prostate 								A	205632669	A	A	205632669	3	1	13	1	0	0	0	0	1	0	0	0	14642	1116	39	2	1423	2	SLC45A3	1	205632669	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	60073810	205632669	43617952	4	894											
FAM177B	400823	broad.mit.edu	37	chr1	222919976	222919976	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaggattatccattttgttgAcggagacatcatggaagaat	10	5	1	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr1:222919976A>G	uc001hnt.2	+	3	355	c.89A>G	c.(88-90)GAC>GGC	p.D30G	uc001hnr.1_Intron|FAM177B_uc009xeb.2_RNA	NM_207468	NP_997351	A6PVY3	F177B_HUMAN	hypothetical protein LOC400823	30										ovary(1)	1						CATTTTGTTGACGGAGACATC	0.323													G	222919976	G	G	222919976	3	3	13	1	0	0	0	0	1	0	0	0	5502	275	10	4	91	4	FAM177B	1	222919976	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	17287307	222919976	26330645	5	895											
EXO1	9156	broad.mit.edu	37	chr1	242048792	242048792	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaactcaatgagctctggaaAaactttggatttaaaaagtg	8	5	2	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr1:242048792A>G	uc001hzh.2	+	15	2928	c.2388A>G	c.(2386-2388)AAA>AAG	p.K796K	EXO1_uc001hzi.2_Silent_p.K796K|EXO1_uc001hzj.2_Silent_p.K796K|EXO1_uc009xgq.2_Silent_p.K795K	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	796	Interaction with MLH1.|Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			AGCTCTGGAAAAACTTTGGAT	0.418								Direct_reversal_of_damage|Editing_and_processing_nucleases					G	242048792	G	G	242048792	2	3	13	1	0	0	0	0	0	0	0	1	5300	11	1	4		4	EXO1	1	242048792	Silent	SNP	A	TCGA-06-0128-01A-01D-1490-08	19128816	242048792	7201829	6	896											
WDR43	23160	broad.mit.edu	37	chr2	29158460	29158460	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccctgcatactattattcCgttgttacaagaggtaactg	8	10	0	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:29158460C>T	uc002rmo.2	+	12	1543	c.1511C>T	c.(1510-1512)CCG>CTG	p.P504L		NM_015131	NP_055946	Q15061	WDR43_HUMAN	WD repeat domain 43	504						nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					ACTATTATTCCGTTGTTACAA	0.328													T	29158460	T	T	29158460	3	4	13	1	0	0	0	0	1	0	0	0	17292	652	23	2	1557	2	WDR43	2	29158460	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08		29158460	214040913	7	897											
THADA	63892	broad.mit.edu	37	chr2	43804328	43804328	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggctcctgcagctgctcatAaaccactcggggacactggt	11	13	1	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:43804328A>T	uc002rsw.3	-	10	1222	c.870T>A	c.(868-870)TTT>TTA	p.F290L	THADA_uc002rsx.3_Missense_Mutation_p.F290L|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_5'Flank|THADA_uc002rsz.2_5'UTR|THADA_uc002rta.2_5'UTR|THADA_uc002rtb.1_Missense_Mutation_p.F290L|THADA_uc002rtc.3_Missense_Mutation_p.F290L|THADA_uc002rtd.2_Missense_Mutation_p.F290L	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	290							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AGCTGCTCATAAACCACTCGG	0.478											OREG0014580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	43804328	T	T	43804328	3	4	13	1	0	0	0	0	1	0	0	0	15837	359	13	5	5107	5	THADA	2	43804328	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	14645868	43804328	199395045	8	898											
SLC3A1	6519	broad.mit.edu	37	chr2	44528234	44528234	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgcagcttccggcagaccatGgaccaatacagcacggagcc	11	15	0	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:44528234G>C	uc002ruc.3	+	6	1182	c.1104G>C	c.(1102-1104)ATG>ATC	p.M368I	SLC3A1_uc002rty.2_Missense_Mutation_p.M368I|SLC3A1_uc002rtz.2_Missense_Mutation_p.M368I|SLC3A1_uc002rua.2_Missense_Mutation_p.M368I|SLC3A1_uc002rub.2_Missense_Mutation_p.M368I|SLC3A1_uc002rud.3_Missense_Mutation_p.M90I|SLC3A1_uc002rue.3_5'Flank	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	368	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	GGCAGACCATGGACCAATACA	0.532													C	44528234	C	C	44528234	3	2	13	1	0	0	0	0	1	0	0	0	14626	1348	47	5	1126	5	SLC3A1	2	44528234	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	723906	44528234	198671139	9	899											
ACVR1	90	broad.mit.edu	37	chr2	158626971	158626971	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggaggagaagatcttcacGgcaacattctccccttgcca	10	13	3	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:158626971G>A	uc002tzm.3	-	8	1038	c.699C>T	c.(697-699)GCC>GCT	p.A233A	ACVR1_uc002tzn.3_Silent_p.A233A|ACVR1_uc010fog.2_Silent_p.A233A	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	233	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	AGATCTTCACGGCAACATTCT	0.463													A	158626971	A	A	158626971	2	1	13	1	0	0	0	0	0	0	0	1	220	1103	39	2		2	ACVR1	2	158626971	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08	114098737	158626971	84572402	10	900											
TTN	7273	broad.mit.edu	37	chr2	179528601	179528601	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaagggcactttctcttcGcggataacctctttggaagc	10	12	2	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:179528601G>A	uc010zfk.1	-	15	1379	c.831C>T	c.(829-831)CGC>CGT	p.R277R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTCTCTTCGCGGATAACCT	0.423													A	179528601	A	A	179528601	2	1	13	1	0	0	0	0	0	0	0	1	16732	1102	38	1		1	TTN	2	179528601	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08	20901630	179528601	63670772	11	901											
TTN	7273	broad.mit.edu	37	chr2	179575886	179575886	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctccggtcagttttaaaaatAttgagtgtggctgtattgtc	10	6	1	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:179575886A>C	uc010zfg.1	-	94	24569	c.24345T>G	c.(24343-24345)AAT>AAG	p.N8115K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.N4776K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9042							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTAAAAATATTGAGTGTGG	0.448													C	179575886	C	C	179575886	3	2	13	1	0	0	0	0	1	0	0	0	16732	446	16	5	76516	5	TTN	2	179575886	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	47285	179575886	63623487	12	902											
NCKAP1	10787	broad.mit.edu	37	chr2	183860521	183860521	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctggtcagctgaaagattccTtcgaggatataccatttgaa	9	8	1	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:183860521T>C	uc002upc.2	-	7	1051	c.649A>G	c.(649-651)AGG>GGG	p.R217G	NCKAP1_uc002upb.2_Missense_Mutation_p.R223G	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	217					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GAAAGATTCCTTCGAGGATAT	0.373													C	183860521	C	C	183860521	3	2	13	1	0	0	0	0	1	0	0	0	10221	1608	56	4	2837	4	NCKAP1	2	183860521	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08	4284635	183860521	59338852	13	903											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	13	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08	25252591	209113112	34086261	14	904											
BCS1L	617	broad.mit.edu	37	chr2	219527689	219527689	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtggcttccaccgaggccCgcatcgtgttcatgaccacc	11	15	1	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:219527689C>T	uc002vio.2	+	7	1391	c.973C>T	c.(973-975)CGC>TGC	p.R325C	BCS1L_uc002vip.2_Missense_Mutation_p.R325C|BCS1L_uc002viq.2_Missense_Mutation_p.R325C|BCS1L_uc010fvu.2_Missense_Mutation_p.R325C|BCS1L_uc010fvv.2_Missense_Mutation_p.R325C|BCS1L_uc002vir.2_Missense_Mutation_p.R325C|BCS1L_uc002vis.2_Missense_Mutation_p.R325C	NM_004328	NP_004319	Q9Y276	BCS1_HUMAN	BCS1-like	325	Mitochondrial matrix (Potential).				mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACCGAGGCCCGCATCGTGTT	0.577													T	219527689	T	T	219527689	3	4	13	1	0	0	0	0	1	0	0	0	1389	652	23	2	995	2	BCS1L	2	219527689	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08	10414577	219527689	23671684	15	905											
ANO7	50636	broad.mit.edu	37	chr2	242147068	242147068	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttctggctgctctccagcGcctgtgccctggcccaggta	11	16	2	0	rs137878201		TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr2:242147068G>A	uc002wax.2	+	11	1325	c.1222G>A	c.(1222-1224)GCC>ACC	p.A408T		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	408	Extracellular (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						GCTCTCCAGCGCCTGTGCCCT	0.622													A	242147068	A	A	242147068	3	1	13	1	0	0	0	0	1	0	0	0	702	1087	38	1	1336	1	ANO7	2	242147068	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	22619379	242147068	1052305	16	906											
FGD5	152273	broad.mit.edu	37	chr3	14862089	14862089	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccctgaagaaaccggacctgAggcgggctcgtcagcccctg	13	15	1	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr3:14862089A>G	uc003bzc.2	+	1	1621	c.1511A>G	c.(1510-1512)GAG>GGG	p.E504G	FGD5_uc011avk.1_Missense_Mutation_p.E504G	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	504					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						ACCGGACCTGAGGCGGGCTCG	0.637													G	14862089	G	G	14862089	3	3	13	1	0	0	0	0	1	0	0	0	5836	304	11	4	1513	4	FGD5	3	14862089	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08		14862089	183160341	17	907											
KALRN	8997	broad.mit.edu	37	chr3	124438292	124438292	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caatgtcaagagctacattgTcaaccgggtgaaccaaggga	11	9	2	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr3:124438292T>C	uc003ehg.2	+	60	9063	c.8936T>C	c.(8935-8937)GTC>GCC	p.V2979A	KALRN_uc003ehk.2_Missense_Mutation_p.V1282A	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2978					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGCTACATTGTCAACCGGGTG	0.502													C	124438292	C	C	124438292	3	2	13	1	0	0	0	0	1	0	0	0	7975	1667	58	4	9330	4	KALRN	3	124438292	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08	109576203	124438292	73584138	18	908											
ATR	545	broad.mit.edu	37	chr3	142188272	142188272	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagacaacaaaaacttcatcGtgagaatgacaaattcgaga	7	7	1	4			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr3:142188272G>A	uc003eux.3	-	38	6581	c.6459C>T	c.(6457-6459)CAC>CAT	p.H2153H	ATR_uc003euy.1_Silent_p.H39H	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2153	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						AAACTTCATCGTGAGAATGAC	0.343								Other_conserved_DNA_damage_response_genes					A	142188272	A	A	142188272	2	1	13	1	0	0	0	0	0	0	0	1	1204	1136	40	1		1	ATR	3	142188272	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08	17749980	142188272	55834158	19	909											
ABCC5	10057	broad.mit.edu	37	chr3	183700632	183700632	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atgccatggttaggatggccCcccgcaagcggacaccggtt	13	13	0	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr3:183700632C>G	uc003fmg.2	-	6	920	c.755G>C	c.(754-756)GGG>GCG	p.G252A	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Missense_Mutation_p.G252A	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	252	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TAGGATGGCCCCCCGCAAGCG	0.507													G	183700632	G	G	183700632	3	3	13	1	0	0	0	0	1	0	0	0	56	623	22	5	3658	5	ABCC5	3	183700632	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08	41512360	183700632	14321798	20	910											
FAM193A	8603	broad.mit.edu	37	chr4	2698176	2698176	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagaggaaagaggagcaaccTaaaaaaatggaccagatctc	10	7	1	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr4:2698176T>C	uc010icl.2	+	16	2841	c.2490T>C	c.(2488-2490)CCT>CCC	p.P830P	FAM193A_uc010ick.2_Silent_p.P1030P|FAM193A_uc003gfd.2_Silent_p.P830P|FAM193A_uc011bvm.1_Silent_p.P852P|FAM193A_uc011bvn.1_Silent_p.P830P|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Silent_p.P684P	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	830										ovary(3)	3						AGGAGCAACCTAAAAAAATGG	0.453													C	2698176	C	C	2698176	2	2	13	1	0	0	0	0	0	0	0	1	5524	1509	53	4		4	FAM193A	4	2698176	Silent	SNP	T	TCGA-06-0128-01A-01D-1490-08		2698176	188456100	21	911											
SLIT2	9353	broad.mit.edu	37	chr4	20547701	20547701	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggttcccaaggaactctccaActacaaacatttaacactta	4	12	1	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr4:20547701A>G	uc003gpr.1	+	22	2528	c.2324A>G	c.(2323-2325)AAC>AGC	p.N775S	SLIT2_uc003gps.1_Missense_Mutation_p.N767S	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	775	LRR 17.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding	p.N775S(1)		central_nervous_system(4)|skin(4)|ovary(3)	11						GAACTCTCCAACTACAAACAT	0.358													G	20547701	G	G	20547701	3	3	13	1	0	0	0	0	1	0	0	0	14740	43	2	4	2410	4	SLIT2	4	20547701	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	17849525	20547701	170606575	22	912											
KDR	3791	broad.mit.edu	37	chr4	55958819	55958819	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaactccatgcccttagccaCttggaagctgtaacagatga	9	11	0	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr4:55958819C>T	uc003has.2	-	22	3336	c.3034G>A	c.(3034-3036)GTG>ATG	p.V1012M	KDR_uc003hat.1_Missense_Mutation_p.V1012M	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1012	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCCTTAGCCACTTGGAAGCTG	0.463			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			T	55958819	T	T	55958819	3	4	13	1	0	0	0	0	1	0	0	0	8139	565	20	3	1072	3	KDR	4	55958819	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08	35411118	55958819	135195457	23	913											
TMPRSS11A	339967	broad.mit.edu	37	chr4	68784796	68784796	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcgtatgtcatccgaaaaggTgactctggaagagacctgca	12	9	2	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr4:68784796T>G	uc003hdr.1	-	8	977	c.856A>C	c.(856-858)ACC>CCC	p.T286P	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.T283P	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	286	Peptidase S1.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						TCCGAAAAGGTGACTCTGGAA	0.433													G	68784796	G	G	68784796	3	3	13	1	0	0	0	0	1	0	0	0	16236	1696	59	5	421	5	TMPRSS11A	4	68784796	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08	12825977	68784796	122369480	24	914											
UGT2B10	7365	broad.mit.edu	37	chr4	69874638	69874638	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tactcgacattgtgttgaagTccactctaacagctgttccc	7	12	1	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr4:69874638T>C	uc011cao.1	-	8	1269	c.1133A>G	c.(1132-1134)GAC>GGC	p.D378G	UGT2B10_uc011can.1_Missense_Mutation_p.D294G			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	415					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TGTGTTGAAGTCCACTCTAAC	0.403													C	69874638	C	C	69874638	3	2	13	1	0	0	0	0	1	0	0	0	16953	1667	58	4	1961	4	UGT2B10	4	69874638	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08	1089842	69874638	121279638	25	915											
ADAM29	11086	broad.mit.edu	37	chr4	175897388	175897388	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tagtggattccattttggatGtcattggtgttaaggtgtta	12	3	1	0	rs148389603		TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr4:175897388G>C	uc003iuc.2	+	5	1382	c.712G>C	c.(712-714)GTC>CTC	p.V238L	ADAM29_uc003iud.2_Missense_Mutation_p.V238L|ADAM29_uc010irr.2_Missense_Mutation_p.V238L|ADAM29_uc011cki.1_Missense_Mutation_p.V238L	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	238	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CATTTTGGATGTCATTGGTGT	0.348													C	175897388	C	C	175897388	3	2	13	1	0	0	0	0	1	0	0	0	247	1377	48	5	714	5	ADAM29	4	175897388	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	106022750	175897388	15256888	26	916											
PIK3R1	5295	broad.mit.edu	37	chr5	67589138	67589138	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	attgtttttacaggaaagggGgaaataacaaattaatcaaa	8	3	1	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr5:67589138G>C	uc003jva.2	+	10	1686	c.1126G>C	c.(1126-1128)GGA>CGA	p.G376R	PIK3R1_uc003jvb.2_Missense_Mutation_p.G376R|PIK3R1_uc003jvc.2_Missense_Mutation_p.G76R|PIK3R1_uc003jvd.2_Missense_Mutation_p.G106R|PIK3R1_uc003jve.2_Missense_Mutation_p.G55R|PIK3R1_uc011crb.1_Missense_Mutation_p.G46R	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	376	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.G376R(3)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CAGGAAAGGGGGAAATAACAA	0.308			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			C	67589138	C	C	67589138	3	2	13	1	0	0	0	0	1	0	0	0	11918	1233	43	5	1290	5	PIK3R1	5	67589138	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08		67589138	113326122	27	917											
PCDHA8	56140	broad.mit.edu	37	chr5	140222411	140222411	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagcggcgggtgggcgagcGctcgctgtcgagctacattt	18	10	0	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr5:140222411G>A	uc003lhs.2	+	1	1505	c.1505G>A	c.(1504-1506)CGC>CAC	p.R502H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.R502H	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	502	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGGCGAGCGCTCGCTGTCG	0.672													A	140222411	A	A	140222411	3	1	13	1	0	0	0	0	1	0	0	0	11530	1087	38	1	1507	1	PCDHA8	5	140222411	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	72633273	140222411	40692849	28	918											
PCDHGA12	26025	broad.mit.edu	37	chr5	140810513	140810513	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgggagctcgcggagcgcGgagtccgcatcatccccaga	14	16	1	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr5:140810513G>A	uc003lkt.1	+	1	356	c.187G>A	c.(187-189)GGA>AGA	p.G63R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.G63R	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	63	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGGAGCGCGGAGTCCGCAT	0.652													A	140810513	A	A	140810513	3	1	13	1	0	0	0	0	1	0	0	0	11553	1117	39	2	189	2	PCDHGA12	5	140810513	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	588102	140810513	40104747	29	919											
ODZ2	57451	broad.mit.edu	37	chr5	167553791	167553791	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagactgtggcactcacggcGtctgcatcgggggagcctgc	15	12	2	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr5:167553791G>A	uc010jjd.2	+	12	2242	c.2242G>A	c.(2242-2244)GTC>ATC	p.V748I	ODZ2_uc003lzr.3_Missense_Mutation_p.V516I|ODZ2_uc003lzt.3_Missense_Mutation_p.V112I|ODZ2_uc010jje.2_Missense_Mutation_p.V19I|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CACTCACGGCGTCTGCATCGG	0.587													A	167553791	A	A	167553791	3	1	13	1	0	0	0	0	1	0	0	0	10835	1145	40	1	2288	1	ODZ2	5	167553791	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	26743278	167553791	13361469	30	920											
PPIL6	285755	broad.mit.edu	37	chr6	109752491	109752491	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	caatgcatcacccagaaactGaccattaacaaaagaaatca	4	11	2	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr6:109752491G>A	uc003ptg.3	-	3	343	c.289C>T	c.(289-291)CAG>TAG	p.Q97*	PPIL6_uc010kdo.2_Nonsense_Mutation_p.Q65*|PPIL6_uc010kdp.2_Nonsense_Mutation_p.Q97*	NM_173672	NP_775943	Q8IXY8	PPIL6_HUMAN	peptidylprolyl isomerase-like 6 isoform 1	97					protein folding		peptidyl-prolyl cis-trans isomerase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.00684)|BRCA - Breast invasive adenocarcinoma(108;0.00889)|all cancers(137;0.0106)|OV - Ovarian serous cystadenocarcinoma(136;0.0259)		CCCAGAAACTGACCATTAACA	0.403													A	109752491	A	A	109752491	4	1	13	1	0	0	0	0	0	1	0	0	12331	1299	45	3	752	3	PPIL6	6	109752491	Nonsense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08		109752491	61362576	31	921											
HOXA2	3199	broad.mit.edu	37	chr7	27142031	27142031	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgaactttgaaatgtaTcagcgacagggggaaaagat	12	4	1	4			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr7:27142031T>A	uc003syh.2	-	1	364	c.89A>T	c.(88-90)GAT>GTT	p.D30V		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	30						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TTGAAATGTATCAGCGACAGG	0.493													A	27142031	A	A	27142031	3	1	13	1	0	0	0	0	1	0	0	0	7292	1435	50	5	1049	5	HOXA2	7	27142031	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08		27142031	131996632	32	922											
GCK	2645	broad.mit.edu	37	chr7	44189583	44189583	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcacccctctccgtttgatAgcgtctcgcagaagccccac	7	18	3	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr7:44189583A>G	uc003tkl.2	-	5	1034	c.564T>C	c.(562-564)GCT>GCC	p.A188A	GCK_uc003tkj.1_Silent_p.A187A|GCK_uc003tkk.1_Silent_p.A189A	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	188			A -> T (in MODY2; large increase in Km for glucose).		cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						TCCGTTTGATAGCGTCTCGCA	0.632													G	44189583	G	G	44189583	2	3	13	1	0	0	0	0	0	0	0	1	6293	407	15	4		4	GCK	7	44189583	Silent	SNP	A	TCGA-06-0128-01A-01D-1490-08	17047552	44189583	114949080	33	923											
MAGI2	9863	broad.mit.edu	37	chr7	77797372	77797372	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acaagctcatctcctgggtgAaggcggccatctctgtcggc	12	13	3	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr7:77797372A>T	uc003ugx.2	-	15	2711	c.2457T>A	c.(2455-2457)CTT>CTA	p.L819L	MAGI2_uc003ugy.2_Silent_p.L805L|MAGI2_uc010ldx.1_Silent_p.L412L	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	819	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTCCTGGGTGAAGGCGGCCAT	0.517													T	77797372	T	T	77797372	2	4	13	1	0	0	0	0	0	0	0	1	9191	233	9	5		5	MAGI2	7	77797372	Silent	SNP	A	TCGA-06-0128-01A-01D-1490-08	33607789	77797372	81341291	34	924											
SAMD9L	219285	broad.mit.edu	37	chr7	92763379	92763379	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaagaagatccacgggcggGcaaaaaccttcttgatgacc	11	10	1	5			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr7:92763379G>A	uc003umh.1	-	5	3122	c.1906C>T	c.(1906-1908)CCC>TCC	p.P636S	SAMD9L_uc003umj.1_Missense_Mutation_p.P636S|SAMD9L_uc003umi.1_Missense_Mutation_p.P636S|SAMD9L_uc010lfb.1_Missense_Mutation_p.P636S|SAMD9L_uc003umk.1_Missense_Mutation_p.P636S|SAMD9L_uc010lfc.1_Missense_Mutation_p.P636S|SAMD9L_uc010lfd.1_Missense_Mutation_p.P636S|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	636										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CCACGGGCGGGCAAAAACCTT	0.398													A	92763379	A	A	92763379	3	1	13	1	0	0	0	0	1	0	0	0	13827	1203	42	3	2852	3	SAMD9L	7	92763379	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	14966007	92763379	66375284	35	925											
PPP1R3A	5506	broad.mit.edu	37	chr7	113519285	113519285	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tcctcaaaacatttccagttCttgatgaacaaacttgacca	4	11	2	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr7:113519285C>A	uc010ljy.1	-	4	1893	c.1862G>T	c.(1861-1863)AGA>ATA	p.R621I		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	621					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ATTTCCAGTTCTTGATGAACA	0.383													A	113519285	A	A	113519285	3	1	13	1	0	0	0	0	1	0	0	0	12371	913	32	5	1510	5	PPP1R3A	7	113519285	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08	20755906	113519285	45619378	36	926											
TUSC3	7991	broad.mit.edu	37	chr8	15519674	15519674	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catttttgcagattcgggttTtcagaccacccaactactct	6	12	2	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr8:15519674T>C	uc003wwt.2	+	5	787	c.577T>C	c.(577-579)TTC>CTC	p.F193L	TUSC3_uc003wwr.2_Missense_Mutation_p.F193L|TUSC3_uc003wws.2_Missense_Mutation_p.F193L|TUSC3_uc003wwu.2_Missense_Mutation_p.F193L|TUSC3_uc003wwv.2_Missense_Mutation_p.F193L|TUSC3_uc003www.2_Missense_Mutation_p.F193L|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.F193L	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	193					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex		p.F193L(1)		ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		GATTCGGGTTTTCAGACCACC	0.353													C	15519674	C	C	15519674	3	2	13	1	0	0	0	0	1	0	0	0	16775	1841	64	4	595	4	TUSC3	8	15519674	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08		15519674	130844348	37	927											
LINGO2	158038	broad.mit.edu	37	chr9	27949442	27949443	+	Frame_Shift_Ins	INS	-	T	T													ttcttttcacggattttgggINSttttttgcaggtaaagtaaa							TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr9:27949442_27949443insT	uc003zqu.1	-	2	1421_1422	c.1227_1228insA	c.(1225-1230)AAACCCfs	p.K409fs	LINGO2_uc010mjf.1_Frame_Shift_Ins_p.K409fs|LINGO2_uc003zqv.1_Frame_Shift_Ins_p.K409fs	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	409_410	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CGGATTTTGGGTTTTTTGCAGG	0.49													T	27949443	T	T	27949442	7	5	13	1	0	1	1	0	0	0	0	0	8815	1261	44	0	596	0	LINGO2	9	27949442	Frame_Shift_Ins	INS	-	TCGA-06-0128-01A-01D-1490-08		27949442	113263989	38	928											
TRIM32	22954	broad.mit.edu	37	chr9	119461599	119461599	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgtgatgctgagggcacCgtctacttcacccagggctt	11	13	2	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr9:119461599C>T	uc004bjx.2	+	2	1736	c.1578C>T	c.(1576-1578)ACC>ACT	p.T526T	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Silent_p.T526T	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	526					fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding	p.T526T(1)		central_nervous_system(2)|kidney(1)	3						CTGAGGGCACCGTCTACTTCA	0.542									Bardet-Biedl_syndrome				T	119461599	T	T	119461599	2	4	13	1	0	0	0	0	0	0	0	1	16503	639	23	2		2	TRIM32	9	119461599	Silent	SNP	C	TCGA-06-0128-01A-01D-1490-08	91512157	119461599	21751832	39	929											
GARNL3	84253	broad.mit.edu	37	chr9	130155514	130155514	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacggctttctccgatgaagAcattatagacttgaagtaac	8	9	1	4			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr9:130155514A>G	uc011mae.1	+	28	3424	c.3023A>G	c.(3022-3024)GAC>GGC	p.D1008G	GARNL3_uc011mad.1_Missense_Mutation_p.D986G|GARNL3_uc010mxi.2_Missense_Mutation_p.D238G	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	1008					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCCGATGAAGACATTATAGAC	0.483													G	130155514	G	G	130155514	3	3	13	1	0	0	0	0	1	0	0	0	6241	275	10	4	3133	4	GARNL3	9	130155514	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	10693915	130155514	11057917	40	930											
RRP8	23378	broad.mit.edu	37	chr11	6622635	6622635	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cctgggaacaggagacacctCtgtcttctctgtgggggcct	13	12	3	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr11:6622635C>G	uc001med.2	-	3	740	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	ILK_uc001mee.2_5'Flank|ILK_uc001mef.2_5'Flank|ILK_uc010rap.1_5'Flank|ILK_uc010raq.1_5'Flank|ILK_uc001meg.2_5'Flank|ILK_uc001meh.2_5'Flank	NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	221					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0						GGAGACACCTCTGTCTTCTCT	0.607													G	6622635	G	G	6622635	3	3	13	1	0	0	0	0	1	0	0	0	13690	922	32	5	729	5	RRP8	11	6622635	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08		6622635	128383881	41	931											
OR8J3	81168	broad.mit.edu	37	chr11	55904564	55904564	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agatactagaactgtaatcaTggaaaaaaccaaatttgttg	7	5	1	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr11:55904564T>C	uc010riz.1	-	1	631	c.631A>G	c.(631-633)ATG>GTG	p.M211V		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					ACTGTAATCATGGAAAAAACC	0.358													C	55904564	C	C	55904564	3	2	13	1	0	0	0	0	1	0	0	0	11242	1464	51	4	318	4	OR8J3	11	55904564	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08	49281929	55904564	79101952	42	932											
MS4A14	84689	broad.mit.edu	37	chr11	60164186	60164186	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aagggagagccaagagtcttGggggtaagtcctctccagtc	14	9	2	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr11:60164186G>T	uc001npj.2	+	1	700	c.135G>T	c.(133-135)TTG>TTT	p.L45F	MS4A14_uc001npi.2_Intron|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.L45F|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	45						integral to membrane	receptor activity			breast(1)	1						CAAGAGTCTTGGGGGTAAGTC	0.423													T	60164186	T	T	60164186	3	4	13	1	0	0	0	0	1	0	0	0	9858	1339	47	5	137	5	MS4A14	11	60164186	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	4259622	60164186	74842330	43	933											
TPCN2	219931	broad.mit.edu	37	chr11	68822263	68822263	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tattactcgaacgtatgccaAcggtgagaacgcacccatgt	9	11	0	1	rs142314553		TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr11:68822263A>G	uc001oos.2	+	3	365	c.249A>G	c.(247-249)CAA>CAG	p.Q83Q	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Intron|TPCN2_uc010rqg.1_Silent_p.Q83Q	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	83	Cytoplasmic (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ACGTATGCCAACGGTGAGAAC	0.602													G	68822263	G	G	68822263	2	3	13	1	0	0	0	0	0	0	0	1	16393	40	2	4		4	TPCN2	11	68822263	Silent	SNP	A	TCGA-06-0128-01A-01D-1490-08	8658077	68822263	66184253	44	934											
MFRP	83552	broad.mit.edu	37	chr11	119212361	119212361	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggccagactggcactggtgcTccgcttcctggcagacagag	14	13	0	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr11:119212361T>G	uc001pwj.2	-	13	1797	c.1637A>C	c.(1636-1638)GAG>GCG	p.E546A	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Missense_Mutation_p.E428A	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		GCACTGGTGCTCCGCTTCCTG	0.647													G	119212361	G	G	119212361	3	3	13	1	0	0	0	0	1	0	0	0	9526	1551	54	5	106	5	MFRP	11	119212361	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08	50390098	119212361	15794155	45	935											
OR10S1	219873	broad.mit.edu	37	chr11	123847740	123847740	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggatgaggcagcctgcagccAcgatgccaatgctggcaagc	14	12	0	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr11:123847740A>G	uc001pzm.1	-	1	659	c.659T>C	c.(658-660)GTG>GCG	p.V220A		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	220	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GCCTGCAGCCACGATGCCAAT	0.562													G	123847740	G	G	123847740	3	3	13	1	0	0	0	0	1	0	0	0	10918	159	6	4	340	4	OR10S1	11	123847740	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	4635379	123847740	11158776	46	936											
APLP2	334	broad.mit.edu	37	chr11	129999095	129999095	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgccttgcagtctgacccGccacgggtgagtcctgcccc	12	17	1	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr11:129999095G>A	uc010sby.1	+	10	1606	c.1449G>A	c.(1447-1449)CCG>CCA	p.P483P	APLP2_uc001qfp.2_Silent_p.P483P|APLP2_uc001qfq.2_Silent_p.P427P|APLP2_uc010sbz.1_Silent_p.P271P|APLP2_uc001qfr.2_Silent_p.P249P|APLP2_uc001qfs.2_Silent_p.P254P|APLP2_uc001qfv.2_Silent_p.P374P	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	483	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		AGTCTGACCCGCCACGGGTGA	0.572													A	129999095	A	A	129999095	2	1	13	1	0	0	0	0	0	0	0	1	779	1074	38	1		1	APLP2	11	129999095	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08	6151355	129999095	5007421	47	937											
ATN1	1822	broad.mit.edu	37	chr12	7045674	7045674	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccccactctttccctccccCaacaagcctctctgtctcca	2	23	3	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr12:7045674C>T	uc001qrw.1	+	5	1481	c.1244C>T	c.(1243-1245)CCA>CTA	p.P415L	ATN1_uc001qrx.1_Missense_Mutation_p.P415L|ATN1_uc001qry.1_Missense_Mutation_p.P414L	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	415					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TTCCCTCCCCCAACAAGCCTC	0.468													T	7045674	T	T	7045674	3	4	13	1	0	0	0	0	1	0	0	0	1111	594	21	3	1258	3	ATN1	12	7045674	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08		7045674	126806221	48	938											
PDE3A	5139	broad.mit.edu	37	chr12	20790147	20790147	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttagtggaaaatataggaagAaaatgtggccgtattcttag	11	3	1	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr12:20790147A>G	uc001reh.1	+	9	2137	c.2115A>G	c.(2113-2115)AGA>AGG	p.R705R		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	705					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ATATAGGAAGAAAATGTGGCC	0.343													G	20790147	G	G	20790147	2	3	13	1	0	0	0	0	0	0	0	1	11637	243	9	4		4	PDE3A	12	20790147	Silent	SNP	A	TCGA-06-0128-01A-01D-1490-08	13744473	20790147	113061748	49	939											
SACS	26278	broad.mit.edu	37	chr13	23912431	23912431	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccaatgtgtggtttcactgTccacttctggtcctggattt	9	10	2	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr13:23912431T>C	uc001uon.2	-	10	6173	c.5584A>G	c.(5584-5586)ACA>GCA	p.T1862A	SACS_uc001uoo.2_Missense_Mutation_p.T1715A|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1862					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GGTTTCACTGTCCACTTCTGG	0.453													C	23912431	C	C	23912431	3	2	13	1	0	0	0	0	1	0	0	0	13804	1667	58	4	8159	4	SACS	13	23912431	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08		23912431	91257447	50	940											
PAN3	255967	broad.mit.edu	37	chr13	28851372	28851372	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatatttattctttcatgtcAgcaagcagatctgatatcat	5	7	5	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr13:28851372A>G	uc001urz.2	+	14	1620	c.1612_splice	c.e14-2	p.Q538_splice	PAN3_uc001ury.2_Splice_Site_p.Q372_splice|PAN3_uc001urx.2_Splice_Site_p.Q484_splice	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease						nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		CTTTCATGTCAGCAAGCAGAT	0.343													G	28851372	G	G	28851372	5	3	13	1	0	0	0	0	0	0	1	0	11415	202	7	4	2106	4	PAN3	13	28851372	Splice_Site	SNP	A	TCGA-06-0128-01A-01D-1490-08	4938941	28851372	86318506	51	941											
G2E3	55632	broad.mit.edu	37	chr14	31081472	31081472	+	Nonsense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ataaatgaatgctataactaCcttgagttaattggatgtct	7	5	1	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr14:31081472C>G	uc001wqk.2	+	13	1714	c.1560C>G	c.(1558-1560)TAC>TAG	p.Y520*	G2E3_uc010tpf.1_Nonsense_Mutation_p.Y474*|G2E3_uc001wql.1_Nonsense_Mutation_p.Y32*	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	520	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GCTATAACTACCTTGAGTTAA	0.318													G	31081472	G	G	31081472	4	3	13	1	0	0	0	0	0	1	0	0	6140	518	18	5	1606	5	G2E3	14	31081472	Nonsense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08		31081472	76268068	52	942											
WDHD1	11169	broad.mit.edu	37	chr14	55451511	55451511	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agagggtcaccatgcaaaatTtgttttttctttttccccag	7	9	2	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr14:55451511T>G	uc001xbm.1	-	15	1914	c.1836A>C	c.(1834-1836)CAA>CAC	p.Q612H	WDHD1_uc010aom.1_Missense_Mutation_p.Q129H|WDHD1_uc001xbn.1_Missense_Mutation_p.Q489H	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	612				Q -> K (in Ref. 2; AAH43349/AAH00622).		cytoplasm|nucleoplasm	DNA binding			skin(1)	1						CATGCAAAATTTGTTTTTTCT	0.378													G	55451511	G	G	55451511	3	3	13	1	0	0	0	0	1	0	0	0	17268	1838	64	5	1601	5	WDHD1	14	55451511	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08	24370039	55451511	51898029	53	943											
TCF12	6938	broad.mit.edu	37	chr15	57554312	57554313	+	Frame_Shift_Del	DEL	CT	-	-													gttggaactcatcgggaagaCtctgtcagtctcaatggcaa							TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr15:57554312_57554313delCT	uc002aec.2	+	16	1700_1701	c.1416_1417delCT	c.(1414-1419)GACTCTfs	p.D472fs	TCF12_uc010ugm.1_Frame_Shift_Del_p.D524fs|TCF12_uc010ugn.1_Frame_Shift_Del_p.D492fs|TCF12_uc002aea.2_Frame_Shift_Del_p.D496fs|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Frame_Shift_Del_p.D496fs|TCF12_uc002aed.2_Frame_Shift_Del_p.D472fs|TCF12_uc002aee.2_Frame_Shift_Del_p.D302fs|TCF12_uc010bft.2_Frame_Shift_Del_p.D326fs|TCF12_uc010ugo.1_Frame_Shift_Del_p.D236fs|TCF12_uc010ugp.1_Frame_Shift_Del_p.D130fs|TCF12_uc010ugq.1_Frame_Shift_Del_p.D106fs|TCF12_uc010ugr.1_Frame_Shift_Del_p.D85fs	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	472_473					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ATCGGGAAGACTCTGTCAGTCT	0.356			T	TEC	extraskeletal myxoid chondrosarcoma								-	57554313	-	-	57554312	7	5	13	1	0	1	0	1	0	0	0	0	15684	564	20	0	1623	0	TCF12	15	57554312	Frame_Shift_Del	DEL	CT	TCGA-06-0128-01A-01D-1490-08		57554312	44977080	54	944											
TCF12	6938	broad.mit.edu	37	chr15	57555309	57555309	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttcctttgcctctttgttaGgtggcttgcaaagtcagtct	9	9	3	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr15:57555309G>C	uc002aec.2	+	17	1795	c.1511_splice	c.e17-1	p.G504_splice	TCF12_uc010ugm.1_Splice_Site_p.G556_splice|TCF12_uc010ugn.1_Splice_Site_p.G524_splice|TCF12_uc002aea.2_Splice_Site_p.G528_splice|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Splice_Site_p.G528_splice|TCF12_uc002aed.2_Splice_Site_p.G504_splice|TCF12_uc002aee.2_Splice_Site_p.G334_splice|TCF12_uc010bft.2_Splice_Site_p.G358_splice|TCF12_uc010ugo.1_Splice_Site_p.G268_splice|TCF12_uc010ugp.1_Splice_Site_p.G162_splice|TCF12_uc010ugq.1_Splice_Site_p.G138_splice|TCF12_uc010ugr.1_Splice_Site_p.G117_splice	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b						immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.?(1)		central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		CTCTTTGTTAGGTGGCTTGCA	0.358			T	TEC	extraskeletal myxoid chondrosarcoma								C	57555309	C	C	57555309	5	2	13	1	0	0	0	0	0	0	1	0	15684	1014	35	5	1721	5	TCF12	15	57555309	Splice_Site	SNP	G	TCGA-06-0128-01A-01D-1490-08	997	57555309	44976083	55	945											
TARSL2	123283	broad.mit.edu	37	chr15	102241320	102241320	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgtaagcgtattataaatgAaggctcctctgggaaggaaa	11	6	1	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr15:102241320A>G	uc002bxm.2	-	10	1344	c.1289T>C	c.(1288-1290)TTC>TCC	p.F430S	TARSL2_uc002bxl.2_5'UTR|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	430					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATTATAAATGAAGGCTCCTCT	0.303													G	102241320	G	G	102241320	3	3	13	1	0	0	0	0	1	0	0	0	15558	246	9	4	1159	4	TARSL2	15	102241320	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	44686011	102241320	290072	56	946											
HBZ	3050	broad.mit.edu	37	chr16	202974	202974	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaagatctccacgcaggcCgacaccatcggcaccgagac	10	17	1	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr16:202974C>T	uc002cft.1	+	1	121	c.66C>T	c.(64-66)GCC>GCT	p.A22A		NM_005332	NP_005323	P02008	HBAZ_HUMAN	hemoglobin, zeta	22						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		all_cancers(16;4.28e-07)|all_epithelial(16;2.09e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				CCACGCAGGCCGACACCATCG	0.597													T	202974	T	T	202974	2	4	13	1	0	0	0	0	0	0	0	1	6989	639	23	2		2	HBZ	16	202974	Silent	SNP	C	TCGA-06-0128-01A-01D-1490-08		202974	90151779	57	947											
SSTR5	6755	broad.mit.edu	37	chr16	1129388	1129388	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctctgtgcatgtcgctgccgCtcctggtgttcgcggacgtg	14	13	1	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr16:1129388C>A	uc002ckq.2	+	1	608	c.520C>A	c.(520-522)CTC>ATC	p.L174I	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	174	Helical; Name=4; (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	GTCGCTGCCGCTCCTGGTGTT	0.721													A	1129388	A	A	1129388	3	1	13	1	0	0	0	0	1	0	0	0	15200	797	28	5	522	5	SSTR5	16	1129388	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08	926414	1129388	89225365	58	948											
C16orf91	283951	broad.mit.edu	37	chr16	1470457	1470457	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttcccatggtatggcccacCgaccagcggtgagggttggc	14	12	0	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr16:1470457C>T	uc002clr.2	-	2	210	c.189G>A	c.(187-189)TCG>TCA	p.S63S	C16orf91_uc010uvd.1_Silent_p.S220S	NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	hypothetical protein LOC283951	63	Extracellular (Potential).					integral to membrane					0						TATGGCCCACCGACCAGCGGT	0.652													T	1470457	T	T	1470457	2	4	13	1	0	0	0	0	0	0	0	1	1844	639	23	2		2	C16orf91	16	1470457	Silent	SNP	C	TCGA-06-0128-01A-01D-1490-08	341069	1470457	88884296	59	949											
PDILT	204474	broad.mit.edu	37	chr16	20370764	20370764	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctcttccagcttggatacGtacttggtcatgttctccag	10	11	3	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr16:20370764G>A	uc002dhc.1	-	12	1855	c.1632C>T	c.(1630-1632)TAC>TAT	p.Y544Y		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	544					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						GCTTGGATACGTACTTGGTCA	0.512													A	20370764	A	A	20370764	2	1	13	1	0	0	0	0	0	0	0	1	11674	1140	40	1		1	PDILT	16	20370764	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08	18900307	20370764	69983989	60	950											
ARMC5	79798	broad.mit.edu	37	chr16	31470871	31470871	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggctgcgaagccaaccctcaCggactcgctctcgttctgcc	10	17	3	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr16:31470871C>A	uc002ecc.2	+	1	555	c.26C>A	c.(25-27)ACG>AAG	p.T9K	ARMC5_uc010vfn.1_Missense_Mutation_p.T104K|ARMC5_uc010vfo.1_Missense_Mutation_p.T41K|ARMC5_uc002eca.3_Missense_Mutation_p.T9K|ARMC5_uc010vfp.1_Missense_Mutation_p.T9K|ARMC5_uc002ecb.2_Missense_Mutation_p.T9K	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	9							binding			pancreas(1)	1						CCAACCCTCACGGACTCGCTC	0.687													A	31470871	A	A	31470871	3	1	13	1	0	0	0	0	1	0	0	0	954	536	19	5	28	5	ARMC5	16	31470871	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08	11100107	31470871	58883882	61	951											
SPNS3	201305	broad.mit.edu	37	chr17	4337372	4337372	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccatcacgcccacctcctGgagcctgcccccgtggaggg	11	19	1	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr17:4337372G>A	uc002fxt.2	+	1	154	c.110G>A	c.(109-111)TGG>TAG	p.W37*	SPNS3_uc002fxu.2_5'UTR	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	37					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						CCCACCTCCTGGAGCCTGCCC	0.657													A	4337372	A	A	4337372	4	1	13	1	0	0	0	0	0	1	0	0	15075	1357	47	3	112	3	SPNS3	17	4337372	Nonsense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08		4337372	76857838	62	952											
TP53	7157	broad.mit.edu	37	chr17	7576910	7576910	+	Frame_Shift_Del	DEL	G	-	-													tttggctggggagaggagctGgtgttgttgggcagtgctag							TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr17:7576910delG	uc002gim.2	-	9	1130	c.936delC	c.(934-936)ACCfs	p.T312fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.T312fs|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Frame_Shift_Del_p.T180fs|TP53_uc010cng.1_Frame_Shift_Del_p.T180fs|TP53_uc002gii.1_Frame_Shift_Del_p.T180fs|TP53_uc010cnh.1_Frame_Shift_Del_p.T312fs|TP53_uc010cni.1_Frame_Shift_Del_p.T312fs|TP53_uc002gij.2_Frame_Shift_Del_p.T312fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	312	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		T -> I (in sporadic cancers; somatic mutation).|T -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.T312S(4)|p.?(2)|p.T312T(2)|p.S313fs*24(2)|p.T312fs*25(1)|p.T312fs*33(1)|p.L308fs*15(1)|p.L308fs*31(1)|p.T312A(1)|p.S313fs*32(1)|p.T312I(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGAGGAGCTGGTGTTGTTGG	0.488		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			-	7576910	-	-	7576910	7	5	13	1	0	1	0	1	0	0	0	0	16378	1335	47	0	346	0	TP53	17	7576910	Frame_Shift_Del	DEL	G	TCGA-06-0128-01A-01D-1490-08	3239538	7576910	73618300	63	953											
KRT34	3885	broad.mit.edu	37	chr17	39538605	39538605	+	Frame_Shift_Del	DEL	G	-	-													ttataccattaattgtgggtGggggcttggcatacagcata							TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr17:39538605delG	uc002hwm.2	-	1	32	c.20delC	c.(19-21)CCAfs	p.P7fs		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	7	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				AATTGTGGGTGGGGGCTTGGC	0.458													-	39538605	-	-	39538605	7	5	13	1	0	1	0	1	0	0	0	0	8471	1348	47	0	1318	0	KRT34	17	39538605	Frame_Shift_Del	DEL	G	TCGA-06-0128-01A-01D-1490-08	31961695	39538605	41656605	64	954											
EVPL	2125	broad.mit.edu	37	chr17	74004095	74004095	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagactcctccccacaggGccccgaggtggtgacctcct	10	18	0	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr17:74004095G>A	uc002jqi.2	-	22	5419	c.5191C>T	c.(5191-5193)CCC>TCC	p.P1731S	EVPL_uc010wss.1_Missense_Mutation_p.P1753S|EVPL_uc010wst.1_Missense_Mutation_p.P1201S	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1731	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TCCCCACAGGGCCCCGAGGTG	0.642													A	74004095	A	A	74004095	3	1	13	1	0	0	0	0	1	0	0	0	5292	1203	42	3	914	3	EVPL	17	74004095	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	34465490	74004095	7191115	65	955											
WDR7	23335	broad.mit.edu	37	chr18	54694330	54694330	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgccccctgtgcagcccgcGtcccccggctcccacaatgc	10	21	0	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr18:54694330G>A	uc002lgk.1	+	28	4576	c.4365G>A	c.(4363-4365)GCG>GCA	p.A1455A	WDR7_uc002lgl.1_Silent_p.A1422A	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1455										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TGCAGCCCGCGTCCCCCGGCT	0.617													A	54694330	A	A	54694330	2	1	13	1	0	0	0	0	0	0	0	1	17317	1132	40	1		1	WDR7	18	54694330	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08		54694330	23382918	66	956											
ZNF407	55628	broad.mit.edu	37	chr18	72345426	72345426	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cttgagaagggcatgctggcGtctgaggaactgtcacagtc	14	9	2	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr18:72345426G>C	uc002llw.2	+	1	2508	c.2451G>C	c.(2449-2451)GCG>GCC	p.A817A	ZNF407_uc010xfc.1_Silent_p.A817A|ZNF407_uc010dqu.1_Silent_p.A817A|ZNF407_uc002llu.2_Silent_p.A816A	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	817					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GCATGCTGGCGTCTGAGGAAC	0.438													C	72345426	C	C	72345426	2	2	13	1	0	0	0	0	0	0	0	1	17884	1132	40	5		5	ZNF407	18	72345426	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08	17651096	72345426	5731822	67	957											
C3	718	broad.mit.edu	37	chr19	6707242	6707242	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatggggttctcccgcatgCcgtcctcgcagcacttgcgc	11	16	2	0			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr19:6707242C>T	uc002mfm.2	-	17	2152	c.2090G>A	c.(2089-2091)GGC>GAC	p.G697D		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	697	Anaphylatoxin-like.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTCCCGCATGCCGTCCTCGCA	0.667													T	6707242	T	T	6707242	3	4	13	1	0	0	0	0	1	0	0	0	2204	739	26	3	3001	3	C3	19	6707242	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08		6707242	52421741	68	958											
ZNF440	126070	broad.mit.edu	37	chr19	11943173	11943173	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggactcacactggagagaaAccctatgagtgtaagcaatg	11	8	1	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr19:11943173A>C	uc002msp.1	+	4	1338	c.1182A>C	c.(1180-1182)AAA>AAC	p.K394N		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGGAGAGAAACCCTATGAGT	0.463													C	11943173	C	C	11943173	3	2	13	1	0	0	0	0	1	0	0	0	17910	40	2	5	1196	5	ZNF440	19	11943173	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	5235931	11943173	47185810	69	959											
BCAM	4059	broad.mit.edu	37	chr19	45315773	45315773	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggtctcccccaacaaagggAcactgtctgtgatggaggac	12	11	2	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr19:45315773A>G	uc002ozu.2	+	4	516	c.472A>G	c.(472-474)ACA>GCA	p.T158A	BCAM_uc002ozt.1_Missense_Mutation_p.T158A	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	158	Extracellular (Potential).|Ig-like V-type 2.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CAACAAAGGGACACTGTCTGT	0.448													G	45315773	G	G	45315773	3	3	13	1	0	0	0	0	1	0	0	0	1344	275	10	4	486	4	BCAM	19	45315773	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	33372600	45315773	13813210	70	960											
ZNF649	65251	broad.mit.edu	37	chr19	52394411	52394411	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agattgcccttctgaatgaaGccttttccacattcactgca	6	12	2	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr19:52394411G>C	uc002pxy.2	-	5	1246	c.978C>G	c.(976-978)GGC>GGG	p.G326G	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	326	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TCTGAATGAAGCCTTTTCCAC	0.458													C	52394411	C	C	52394411	2	2	13	1	0	0	0	0	0	0	0	1	18061	958	34	5		5	ZNF649	19	52394411	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08	7078638	52394411	6734572	71	961			1	5		2	2	13	N	T_G	3.178579e-05
ZNF649	65251	broad.mit.edu	37	chr19	52394423	52394423	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaatgaagccttttccacaTtcactgcatgtatgaggctt	8	9	1	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr19:52394423T>C	uc002pxy.2	-	5	1234	c.966A>G	c.(964-966)GAA>GAG	p.E322E	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	322	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTTTTCCACATTCACTGCATG	0.458													C	52394423	C	C	52394423	2	2	13	1	0	0	0	0	0	0	0	1	18061	1490	52	4		4	ZNF649	19	52394423	Silent	SNP	T	TCGA-06-0128-01A-01D-1490-08	12	52394423	6734560	72	962			1	5		2	2	13	N	T_G	3.178579e-05
KIR2DL1	3802	broad.mit.edu	37	chr19	55284980	55284980	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccaacttctccatcagtcGcatgacgcaagacctggcag	10	14	2	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr19:55284980G>A	uc002qhb.1	+	3	304	c.266G>A	c.(265-267)CGC>CAC	p.R89H	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.R89H	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	89	Extracellular (Potential).|Ig-like C2-type 1.				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		TCCATCAGTCGCATGACGCAA	0.537													A	55284980	A	A	55284980	3	1	13	1	0	0	0	0	1	0	0	0	8316	1087	38	1	276	1	KIR2DL1	19	55284980	Missense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	2890557	55284980	3844003	73	963											
ZNF586	54807	broad.mit.edu	37	chr19	58290731	58290731	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttgagagttcacacaggagAaaggccttatgaatgcgttg	12	7	1	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr19:58290731A>G	uc002qqd.2	+	3	962	c.776A>G	c.(775-777)GAA>GGA	p.E259G	ZNF587_uc002qqb.2_Intron|ZNF586_uc002qqe.2_3'UTR|ZNF586_uc010euh.2_Missense_Mutation_p.E216G|ZNF586_uc002qqf.1_Intron	NM_017652	NP_060122	Q9NXT0	ZN586_HUMAN	zinc finger protein 586	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CACACAGGAGAAAGGCCTTAT	0.443													G	58290731	G	G	58290731	3	3	13	1	0	0	0	0	1	0	0	0	18016	246	9	4	786	4	ZNF586	19	58290731	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	3005751	58290731	838252	74	964											
DNMT3B	1789	broad.mit.edu	37	chr20	31368258	31368258	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcctggaggctatccgcacCccggagatcagaggtggctg	14	12	1	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr20:31368258C>T	uc002wyc.2	+	2	450	c.129C>T	c.(127-129)ACC>ACT	p.T43T	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Silent_p.T43T|DNMT3B_uc002wye.2_Silent_p.T43T|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Silent_p.T43T|DNMT3B_uc010zua.1_Silent_p.T43T|DNMT3B_uc002wyf.2_Silent_p.T55T	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	43	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						CTATCCGCACCCCGGAGATCA	0.652													T	31368258	T	T	31368258	2	4	13	1	0	0	0	0	0	0	0	1	4677	610	22	3		3	DNMT3B	20	31368258	Silent	SNP	C	TCGA-06-0128-01A-01D-1490-08		31368258	31657262	75	965											
SULF2	55959	broad.mit.edu	37	chr20	46307466	46307466	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcttgaggatggatttccCgtccatatccgcaggtatgt	11	10	0	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr20:46307466C>T	uc002xto.2	-	8	1477	c.1147G>A	c.(1147-1149)GGG>AGG	p.G383R	SULF2_uc002xtr.2_Missense_Mutation_p.G383R|SULF2_uc002xtq.2_Missense_Mutation_p.G383R	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	383					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						ATGGATTTCCCGTCCATATCC	0.617													T	46307466	T	T	46307466	3	4	13	1	0	0	0	0	1	0	0	0	15370	652	23	2	1521	2	SULF2	20	46307466	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08	14939208	46307466	16718054	76	966											
CHODL	140578	broad.mit.edu	37	chr21	19638284	19638284	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttcagtaaaggaagaacaAaaactagtccaaaccagtct	6	8	2	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr21:19638284A>G	uc002ykv.2	+	6	1142	c.751A>G	c.(751-753)AAA>GAA	p.K251E	CHODL_uc002ykr.2_Missense_Mutation_p.K210E|CHODL_uc002yks.2_Missense_Mutation_p.K210E|CHODL_uc002ykt.2_Silent_p.Q175Q|CHODL_uc002yku.2_Silent_p.Q175Q	NM_024944	NP_079220	Q9H9P2	CHODL_HUMAN	chondrolectin precursor	251	Cytoplasmic (Potential).				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			upper_aerodigestive_tract(1)	1		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		AGGAAGAACAAAAACTAGTCC	0.343													G	19638284	G	G	19638284	3	3	13	1	0	0	0	0	1	0	0	0	3364	15	1	4	773	4	CHODL	21	19638284	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08		19638284	28491611	77	967											
POTEH	23784	broad.mit.edu	37	chr22	16287511	16287511	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgagtgtcttcatagcagaGtcgtcgtggtctccagaagt	12	9	3	3			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr22:16287511G>A	uc010gqp.2	-	1	427	c.375C>T	c.(373-375)GAC>GAT	p.D125D	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_Intron	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	125										skin(1)	1						TCATAGCAGAGTCGTCGTGGT	0.612													A	16287511	A	A	16287511	2	1	13	1	0	0	0	0	0	0	0	1	12267	1020	36	3		3	POTEH	22	16287511	Silent	SNP	G	TCGA-06-0128-01A-01D-1490-08		16287511	35017055	78	968											
MYO18B	84700	broad.mit.edu	37	chr22	26291213	26291213	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atgcgaggagaggctggactCggagctgacagccaggaaag	17	8	0	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr22:26291213C>T	uc003abz.1	+	28	4884	c.4634C>T	c.(4633-4635)TCG>TTG	p.S1545L	MYO18B_uc003aca.1_Missense_Mutation_p.S1426L|MYO18B_uc010guy.1_Missense_Mutation_p.S1427L|MYO18B_uc010guz.1_Missense_Mutation_p.S1425L|MYO18B_uc011aka.1_Missense_Mutation_p.S699L|MYO18B_uc011akb.1_Missense_Mutation_p.S1058L	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1545	Potential.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGGCTGGACTCGGAGCTGACA	0.552													T	26291213	T	T	26291213	3	4	13	1	0	0	0	0	1	0	0	0	10066	893	31	2	4740	2	MYO18B	22	26291213	Missense_Mutation	SNP	C	TCGA-06-0128-01A-01D-1490-08	10003702	26291213	25013353	79	969											
SF3A1	10291	broad.mit.edu	37	chr22	30738811	30738811	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctgatccaaaacttctcGggggttttcagcctctttct	7	12	4	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr22:30738811G>A	uc003ahl.2	-	5	841	c.709C>T	c.(709-711)CGA>TGA	p.R237*		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	237					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						AAAACTTCTCGGGGGTTTTCA	0.408													A	30738811	A	A	30738811	4	1	13	1	0	0	0	0	0	1	0	0	14146	1124	39	2	1720	2	SF3A1	22	30738811	Nonsense_Mutation	SNP	G	TCGA-06-0128-01A-01D-1490-08	4447598	30738811	20565755	80	970											
GGA1	26088	broad.mit.edu	37	chr22	38016850	38016850	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtccgaccccaagcttccagAtgacactacctttccccttc	5	18	0	2			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chr22:38016850A>G	uc003atc.2	+	6	823	c.458A>G	c.(457-459)GAT>GGT	p.D153G	GGA1_uc003atd.2_Missense_Mutation_p.D153G|GGA1_uc003ate.2_Missense_Mutation_p.D153G|GGA1_uc003atf.2_Missense_Mutation_p.D80G	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	153	Interaction with ARF3.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					AAGCTTCCAGATGACACTACC	0.522													G	38016850	G	G	38016850	3	3	13	1	0	0	0	0	1	0	0	0	6352	333	12	4	546	4	GGA1	22	38016850	Missense_Mutation	SNP	A	TCGA-06-0128-01A-01D-1490-08	7278039	38016850	13287716	81	971											
FTSJ1	24140	broad.mit.edu	37	chrX	48337070	48337070	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggctccactaccaggtgtggTacagatccagggggacatca	13	11	1	1			TCGA-06-0128-01A-01D-1490-08	TCGA-06-0128-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c5688535-bda4-4831-aaba-e0c19101d7b0	8e63435b-e780-4462-bb14-fccc528fe9f5	g.chrX:48337070T>C	uc004djo.1	+	4	580	c.257T>C	c.(256-258)GTA>GCA	p.V86A	FTSJ1_uc004djl.2_Missense_Mutation_p.V86A|FTSJ1_uc004djm.2_Missense_Mutation_p.V86A|FTSJ1_uc004djn.1_Missense_Mutation_p.V86A|FTSJ1_uc004djp.1_Missense_Mutation_p.V86A|FTSJ1_uc011mlw.1_Intron	NM_012280	NP_036412	Q9UET6	RRMJ1_HUMAN	FtsJ homolog 1 isoform a	86					RNA methylation|rRNA processing		methyltransferase activity|nucleic acid binding				0						CCAGGTGTGGTACAGATCCAG	0.567													C	48337070	C	C	48337070	3	2	13	1	0	0	0	0	1	0	0	0	6087	1638	57	4	267	4	FTSJ1	23	48337070	Missense_Mutation	SNP	T	TCGA-06-0128-01A-01D-1490-08		48337070	106933490	82	972											
AADACL4	343066	broad.mit.edu	37	chr1	12726313	12726313	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccattgacctctcctggcGtgacgccatcttgaacggca	11	14	2	3			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr1:12726313G>A	uc001auf.2	+	4	791	c.791G>A	c.(790-792)CGT>CAT	p.R264H		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	264	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		CTCTCCTGGCGTGACGCCATC	0.498													A	12726313	A	A	12726313	3	1	14	1	0	0	0	0	1	0	0	0	13	1145	40	1	805	1	AADACL4	1	12726313	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08		12726313	236524308	1	973											
MCL1	4170	broad.mit.edu	37	chr1	150550855	150550856	+	Frame_Shift_Del	DEL	GA	-	-													acaaaggcaccaaaagaaatGagagtcacaatcctgcccca							TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr1:150550855_150550856delGA	uc001euz.2	-	2	930_931	c.800_801delTC	c.(799-801)CTCfs	p.L267fs	MCL1_uc010pch.1_Frame_Shift_Del_p.L157fs|MCL1_uc001eva.2_Intron	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	267	BH1.				anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CAAAAGAAATGAGAGTCACAAT	0.436													-	150550856	-	-	150550855	7	5	14	1	0	1	0	1	0	0	0	0	9384	1277	45	0	270	0	MCL1	1	150550855	Frame_Shift_Del	DEL	GA	TCGA-06-0129-01A-01D-1490-08	137824542	150550855	98699766	2	974											
MDM4	4194	broad.mit.edu	37	chr1	204507404	204507404	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgatatccccacactgcctaCctcagagcataaatgcatac	5	15	1	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr1:204507404C>G	uc001hba.2	+	7	641	c.479C>G	c.(478-480)ACC>AGC	p.T160S	MDM4_uc001hbd.1_RNA|MDM4_uc010pqw.1_RNA|MDM4_uc010pqx.1_Missense_Mutation_p.T33S|MDM4_uc001hay.1_Missense_Mutation_p.T160S|MDM4_uc001hbb.2_Missense_Mutation_p.T33S|MDM4_uc010pqy.1_Intron|MDM4_uc001hbc.2_RNA|MDM4_uc009xbe.1_RNA	NM_002393	NP_002384	O15151	MDM4_HUMAN	mouse double minute 4 homolog	160					apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding	p.T160S(1)		upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			ACACTGCCTACCTCAGAGCAT	0.393			A		GBM|bladder|retinoblastoma								G	204507404	G	G	204507404	3	3	14	1	0	0	0	0	1	0	0	0	9414	507	18	5	501	5	MDM4	1	204507404	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	53956549	204507404	44743217	3	975											
CR1L	1379	broad.mit.edu	37	chr1	207868047	207868047	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaagggccctcccatgtgaaGtgccaggccctgaacaaatg	11	12	0	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr1:207868047G>T	uc001hga.3	+	5	934	c.813G>T	c.(811-813)AAG>AAT	p.K271N	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	271	Sushi 4.					cytoplasm|extracellular region|membrane					0						CCCATGTGAAGTGCCAGGCCC	0.507													T	207868047	T	T	207868047	3	4	14	1	0	0	0	0	1	0	0	0	3841	1020	36	5	831	5	CR1L	1	207868047	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08	3360643	207868047	41382574	4	976											
USH2A	7399	broad.mit.edu	37	chr1	216052218	216052218	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgaggtacggtggggtgagTggtaacataggtaggtaaac	17	4	0	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr1:216052218T>G	uc001hku.1	-	42	8833	c.8446A>C	c.(8446-8448)ACT>CCT	p.T2816P		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2816	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTGGGGTGAGTGGTAACATAG	0.458										HNSCC(13;0.011)			G	216052218	G	G	216052218	3	3	14	1	0	0	0	0	1	0	0	0	17033	1696	59	5	7286	5	USH2A	1	216052218	Missense_Mutation	SNP	T	TCGA-06-0129-01A-01D-1490-08	8184171	216052218	33198403	5	977											
ITGB1BP1	9270	broad.mit.edu	37	chr2	9547680	9547681	+	Frame_Shift_Del	DEL	AC	-	-													gcccccagaccgtcatcgtaAcacaccatccggattattaa							TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr2:9547680_9547681delAC	uc002qzj.2	-	6	605_606	c.428_429delGT	c.(427-429)TGTfs	p.C143fs	ITGB1BP1_uc002qzk.2_Intron|ITGB1BP1_uc002qzl.2_Intron|ITGB1BP1_uc002qzm.2_RNA|ITGB1BP1_uc010yiy.1_Frame_Shift_Del_p.C99fs|ITGB1BP1_uc002qzn.1_Frame_Shift_Del_p.C143fs	NM_004763	NP_004754	O14713	ITBP1_HUMAN	integrin cytoplasmic domain-associated protein 1	143	PID.				cell migration|cell-matrix adhesion|intracellular protein kinase cascade	cytosol|lamellipodium|membrane|ruffle	protein binding|protein binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.23)		CGTCATCGTAACACACCATCCG	0.48													-	9547681	-	-	9547680	7	5	14	1	0	1	0	1	0	0	0	0	7891	41	2	0	181	0	ITGB1BP1	2	9547680	Frame_Shift_Del	DEL	AC	TCGA-06-0129-01A-01D-1490-08		9547680	233651693	6	978											
OLA1	29789	broad.mit.edu	37	chr2	174945887	174945887	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtatgaatcttaccctgatgGtccatgcacgcacttcatct	7	12	3	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr2:174945887G>C	uc002uih.2	-	9	1145	c.959C>G	c.(958-960)ACC>AGC	p.T320S	OLA1_uc002uii.2_Missense_Mutation_p.T162S|OLA1_uc010fqq.2_Missense_Mutation_p.T299S|OLA1_uc002uij.2_Missense_Mutation_p.T162S|OLA1_uc002uik.2_Missense_Mutation_p.T290S|OLA1_uc010fqr.2_Intron	NM_013341	NP_037473	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1 isoform 1	320					ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			ovary(1)|breast(1)	2						TACCCTGATGGTCCATGCACG	0.418													C	174945887	C	C	174945887	3	2	14	1	0	0	0	0	1	0	0	0	10850	1261	44	5	243	5	OLA1	2	174945887	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08	165398207	174945887	68253486	7	979											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	14	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	34167225	209113112	34086261	8	980											
PROS1	5627	broad.mit.edu	37	chr3	93611922	93611922	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagattctgcgtacagtatcAcgccttctgaatcatatgtc	7	10	4	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr3:93611922A>G	uc003drb.3	-	10	1351	c.1010T>C	c.(1009-1011)GTG>GCG	p.V337A	PROS1_uc010hoo.2_Missense_Mutation_p.V206A|PROS1_uc003dqz.3_Missense_Mutation_p.V206A	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	337	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	GTACAGTATCACGCCTTCTGA	0.398													G	93611922	G	G	93611922	3	3	14	1	0	0	0	0	1	0	0	0	12558	159	6	4	1044	4	PROS1	3	93611922	Missense_Mutation	SNP	A	TCGA-06-0129-01A-01D-1490-08		93611922	104410508	9	981											
C3orf22	152065	broad.mit.edu	37	chr3	126268815	126268815	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagttgtctggggaagcggcGactcagcaacttgagttccc	14	10	2	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr3:126268815G>A	uc003ejb.2	-	4	651	c.322C>T	c.(322-324)CGC>TGC	p.R108C		NM_152533	NP_689746	Q8N5N4	CC022_HUMAN	hypothetical protein LOC152065	108											0				GBM - Glioblastoma multiforme(114;0.147)		GGGAAGCGGCGACTCAGCAAC	0.632													A	126268815	A	A	126268815	3	1	14	1	0	0	0	0	1	0	0	0	2215	1058	37	2	107	2	C3orf22	3	126268815	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08	32656893	126268815	71753615	10	982											
CHST2	9435	broad.mit.edu	37	chr3	142841108	142841108	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcaggccgccaatgcctggCggaccgccctcaccttccag	11	19	1	0			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr3:142841108C>T	uc003evm.2	+	2	2339	c.1450C>T	c.(1450-1452)CGG>TGG	p.R484W		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	484	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						CAATGCCTGGCGGACCGCCCT	0.607													T	142841108	T	T	142841108	3	4	14	1	0	0	0	0	1	0	0	0	3404	759	27	1	1452	1	CHST2	3	142841108	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	16572293	142841108	55181322	11	983											
ZNF721	170960	broad.mit.edu	37	chr4	437518	437518	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tccttacatttgtagggtttCtctccagtatgaattttctc	6	9	2	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr4:437518C>G	uc003gag.2	-	3	1429	c.738G>C	c.(736-738)GAG>GAC	p.E246D	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.E278D|ZNF721_uc010ibe.2_Missense_Mutation_p.E234D	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	246						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TGTAGGGTTTCTCTCCAGTAT	0.368													G	437518	G	G	437518	3	3	14	1	0	0	0	0	1	0	0	0	18119	912	32	5	2037	5	ZNF721	4	437518	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08		437518	190716758	12	984											
FAM193A	8603	broad.mit.edu	37	chr4	2661629	2661629	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gacatccacattcaccagctCccacttcaagtggatcctgc	6	16	2	0			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr4:2661629C>T	uc010icl.2	+	8	1071	c.720C>T	c.(718-720)CTC>CTT	p.L240L	FAM193A_uc010ick.2_Silent_p.L440L|FAM193A_uc003gfd.2_Silent_p.L240L|FAM193A_uc011bvm.1_Silent_p.L264L|FAM193A_uc011bvn.1_Silent_p.L240L|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Silent_p.L94L	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	240										ovary(3)	3						TTCACCAGCTCCCACTTCAAG	0.562													T	2661629	T	T	2661629	2	4	14	1	0	0	0	0	0	0	0	1	5524	842	30	3		3	FAM193A	4	2661629	Silent	SNP	C	TCGA-06-0129-01A-01D-1490-08	2224111	2661629	188492647	13	985											
ZNF518B	85460	broad.mit.edu	37	chr4	10446518	10446518	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaatgaccttttaaggcaaCggaaggaaaagcagttctat	10	6	1	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr4:10446518C>T	uc003gmn.2	-	3	1922	c.1435G>A	c.(1435-1437)GTT>ATT	p.V479I		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						TTTAAGGCAACGGAAGGAAAA	0.348													T	10446518	T	T	10446518	3	4	14	1	0	0	0	0	1	0	0	0	17960	536	19	1	1793	1	ZNF518B	4	10446518	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	7784889	10446518	180707758	14	986											
EXOC1	55763	broad.mit.edu	37	chr4	56750010	56750010	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attacatggattatttatccCgactatatgaaagagaaatc	6	6	0	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr4:56750010C>T	uc003hbe.1	+	10	1404	c.1246C>T	c.(1246-1248)CGA>TGA	p.R416*	EXOC1_uc003hbf.1_Nonsense_Mutation_p.R416*|EXOC1_uc003hbg.1_Nonsense_Mutation_p.R416*	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	416					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					TTATTTATCCCGACTATATGA	0.299													T	56750010	T	T	56750010	4	4	14	1	0	0	0	0	0	1	0	0	5301	644	23	2	1280	2	EXOC1	4	56750010	Nonsense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	46303492	56750010	134404266	15	987											
PIK3R1	5295	broad.mit.edu	37	chr5	67591126	67591127	+	Frame_Shift_Del	DEL	GA	-	-													aaaccagaccttatccagctGagaaagacgagagaccaata							TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr5:67591126_67591127delGA	uc003jva.2	+	13	2279_2280	c.1719_1720delGA	c.(1717-1722)CTGAGAfs	p.L573fs	PIK3R1_uc003jvb.2_Frame_Shift_Del_p.L573fs|PIK3R1_uc003jvc.2_Frame_Shift_Del_p.L273fs|PIK3R1_uc003jvd.2_Frame_Shift_Del_p.L303fs|PIK3R1_uc003jve.2_Frame_Shift_Del_p.L252fs|PIK3R1_uc011crb.1_Frame_Shift_Del_p.L243fs	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	573_574					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.R574_T576del(2)|p.L570_D578del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TTATCCAGCTGAGAAAGACGAG	0.381			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67591127	-	-	67591126	7	5	14	1	0	1	0	1	0	0	0	0	11918	1277	45	0	1895	0	PIK3R1	5	67591126	Frame_Shift_Del	DEL	GA	TCGA-06-0129-01A-01D-1490-08		67591126	113324134	16	988											
SLC12A2	6558	broad.mit.edu	37	chr5	127420118	127420118	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cggctgaagacagcctgtcaGatgctgccggggtcggagtc	16	11	1	3			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr5:127420118G>C	uc003kus.2	+	1	636	c.472G>C	c.(472-474)GAT>CAT	p.D158H	FLJ33630_uc003kun.2_5'Flank|FLJ33630_uc003kuo.2_5'Flank|FLJ33630_uc003kup.1_5'Flank|FLJ33630_uc003kuq.1_5'Flank|FLJ33630_uc003kur.2_5'Flank|SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.D158H	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	158	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CAGCCTGTCAGATGCTGCCGG	0.692													C	127420118	C	C	127420118	3	2	14	1	0	0	0	0	1	0	0	0	14383	942	33	5	474	5	SLC12A2	5	127420118	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08	59828992	127420118	53495142	17	989											
MYOZ3	91977	broad.mit.edu	37	chr5	150050115	150050115	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatggaggagctgtcactacGcaacaacagagggtccctcc	12	12	1	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr5:150050115G>A	uc003lss.2	+	3	718	c.131G>A	c.(130-132)CGC>CAC	p.R44H	MYOZ3_uc003lsr.2_Missense_Mutation_p.R44H	NM_001122853	NP_001116325	Q8TDC0	MYOZ3_HUMAN	myozenin 3	44						sarcomere	protein binding			skin(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGTCACTACGCAACAACAGA	0.607													A	150050115	A	A	150050115	3	1	14	1	0	0	0	0	1	0	0	0	10097	1087	38	1	137	1	MYOZ3	5	150050115	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08	22629997	150050115	30865145	18	990											
PSMB8	5696	broad.mit.edu	37	chr6	32809494	32809494	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgagtcccatgttcatccaCgtagtagagtccaggaccct	9	14	1	1	rs78945358	by1000genomes	TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr6:32809494C>T	uc003oce.2	-	5	599	c.556G>A	c.(556-558)GTG>ATG	p.V186M	TAP2_uc011dqf.1_5'Flank|TAP2_uc003ocb.1_5'Flank|TAP2_uc003ocd.2_5'Flank|PSMB8_uc003ocf.2_Missense_Mutation_p.V182M	NM_148919	NP_683720	P28062	PSB8_HUMAN	proteasome beta 8 subunit isoform E2 proprotein	186					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			skin(1)	1						TGTTCATCCACGTAGTAGAGT	0.463													T	32809494	T	T	32809494	3	4	14	1	0	0	0	0	1	0	0	0	12683	536	19	1	282	1	PSMB8	6	32809494	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08		32809494	138305573	19	991											
CCND3	896	broad.mit.edu	37	chr6	41903737	41903738	+	Frame_Shift_Ins	INS	-	G	G													tggctgggcccttggctgctINSggagccccggggggctttgg							TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr6:41903737_41903738insG	uc003orn.2	-	5	984_985	c.819_820insC	c.(817-822)TCCAGCfs	p.S273fs	CCND3_uc003orp.2_Frame_Shift_Ins_p.S192fs|CCND3_uc011duk.1_Frame_Shift_Ins_p.S77fs|CCND3_uc003orm.2_Frame_Shift_Ins_p.S223fs|CCND3_uc003oro.2_Frame_Shift_Ins_p.S201fs	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	273_274					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCTTGGCTGCTGGAGCCCCGGG	0.649			T	IGH@	MM								G	41903738	G	G	41903737	7	5	14	1	0	1	1	0	0	0	0	0	2918	1580	55	0	62	0	CCND3	6	41903737	Frame_Shift_Ins	INS	-	TCGA-06-0129-01A-01D-1490-08	9094243	41903737	129211330	20	992											
FABP7	2173	broad.mit.edu	37	chr6	123101455	123101455	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgtgggctttgccactagGcaggtgggaaatgtgaccaa	16	8	0	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr6:123101455G>A	uc003pzf.2	+	2	387	c.93G>A	c.(91-93)AGG>AGA	p.R31R	FABP7_uc003pzd.2_Silent_p.R31R|FABP7_uc003pze.1_Silent_p.R31R	NM_001446	NP_001437	O15540	FABP7_HUMAN	fatty acid binding protein 7, brain	31					negative regulation of cell proliferation	cytoplasm	lipid binding|transporter activity				0				GBM - Glioblastoma multiforme(226;0.226)	Alpha-Linolenic Acid(DB00132)|gamma-Homolinolenic acid(DB00154)|Icosapent(DB00159)	TTGCCACTAGGCAGGTGGGAA	0.448													A	123101455	A	A	123101455	2	1	14	1	0	0	0	0	0	0	0	1	5362	1194	42	3		3	FABP7	6	123101455	Silent	SNP	G	TCGA-06-0129-01A-01D-1490-08	81197718	123101455	48013612	21	993											
DYNC1I1	1780	broad.mit.edu	37	chr7	95657586	95657586	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tctgggacaatcgcagtcatCgaaggactccagtgcagcgg	13	11	2	0			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr7:95657586C>T	uc003uoc.3	+	11	1397	c.1120C>T	c.(1120-1122)CGA>TGA	p.R374*	DYNC1I1_uc003uod.3_Nonsense_Mutation_p.R357*|DYNC1I1_uc003uob.2_Nonsense_Mutation_p.R337*|DYNC1I1_uc003uoe.3_Nonsense_Mutation_p.R354*|DYNC1I1_uc010lfl.2_Nonsense_Mutation_p.R363*	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	374	WD 2.				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TCGCAGTCATCGAAGGACTCC	0.547													T	95657586	T	T	95657586	4	4	14	1	0	0	0	0	0	1	0	0	4842	876	31	2	1158	2	DYNC1I1	7	95657586	Nonsense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08		95657586	63481077	22	994											
JPH1	56704	broad.mit.edu	37	chr8	75156952	75156952	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaggaagactggctggAtccatcgccgtcctccacgt	12	13	0	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr8:75156952A>G	uc003yae.2	-	4	1757	c.1717T>C	c.(1717-1719)TCC>CCC	p.S573P	JPH1_uc003yaf.2_Missense_Mutation_p.S573P|JPH1_uc003yag.1_Missense_Mutation_p.S437P	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	573	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GACTGGCTGGATCCATCGCCG	0.552													G	75156952	G	G	75156952	3	3	14	1	0	0	0	0	1	0	0	0	7960	333	12	4	276	4	JPH1	8	75156952	Missense_Mutation	SNP	A	TCGA-06-0129-01A-01D-1490-08		75156952	71207070	23	995											
CRTAC1	55118	broad.mit.edu	37	chr10	99696002	99696002	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgtcgcaggctgtgacccCgatggcgttcccctgccggt	14	14	0	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr10:99696002C>T	uc001kou.1	-	3	702	c.346G>A	c.(346-348)GGG>AGG	p.G116R	CRTAC1_uc001kov.2_Missense_Mutation_p.G105R|CRTAC1_uc001kot.1_5'UTR	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	116	FG-GAP 2; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		GCTGTGACCCCGATGGCGTTC	0.632													T	99696002	T	T	99696002	3	4	14	1	0	0	0	0	1	0	0	0	3896	652	23	2	1691	2	CRTAC1	10	99696002	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08		99696002	35838745	24	996											
C10orf46	143384	broad.mit.edu	37	chr10	120513921	120513923	+	In_Frame_Del	DEL	GGA	-	-													gactcacagaacttggaggtGgaggtgttgatgttgatggt							TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr10:120513921_120513923delGGA	uc001lds.1	-	1	836_838	c.352_354delTCC	c.(352-354)TCCdel	p.S118del	C10orf46_uc010qst.1_RNA	NM_153810	NP_722517	Q86Y37	CJ046_HUMAN	chromosome 10 open reading frame 46	118					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding				0		Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0131)		ACTTGGAGGTGGAGGTGTTGATG	0.621													-	120513923	-	-	120513921	7	5	14	1	0	1	0	1	0	0	0	0	1604	1335	47	0	791	0	C10orf46	10	120513921	In_Frame_Del	DEL	GGA	TCGA-06-0129-01A-01D-1490-08	20817919	120513921	15020826	25	997											
LRRC56	115399	broad.mit.edu	37	chr11	544759	544759	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaccaactgaagctgaacgGcagccacctgggctccctga	12	14	0	3			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr11:544759G>A	uc010qvz.1	+	6	810	c.305G>A	c.(304-306)GGC>GAC	p.G102D		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	102	LRR 1.									skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAGCTGAACGGCAGCCACCTG	0.701													A	544759	A	A	544759	3	1	14	1	0	0	0	0	1	0	0	0	9012	1203	42	3	315	3	LRRC56	11	544759	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08		544759	134461757	26	998											
SLC22A25	387601	broad.mit.edu	37	chr11	62995959	62995959	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacaaatggccatataggttGcctcccaccatcattccagc	7	14	1	0			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr11:62995959G>A	uc001nwr.1	-	2	480	c.480C>T	c.(478-480)GGC>GGT	p.G160G	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_Intron|SLC22A25_uc001nwt.1_Silent_p.G160G	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	160	Helical; Name=2; (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						CATATAGGTTGCCTCCCACCA	0.408													A	62995959	A	A	62995959	2	1	14	1	0	0	0	0	0	0	0	1	14454	1306	46	3		3	SLC22A25	11	62995959	Silent	SNP	G	TCGA-06-0129-01A-01D-1490-08	62451200	62995959	72010557	27	999											
CREBZF	58487	broad.mit.edu	37	chr11	85375242	85375244	+	In_Frame_Del	DEL	CTT	-	-													tccagccccatcacgtactcCttcttcttcagtcgattaag							TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr11:85375242_85375244delCTT	uc001pas.2	-	1	939_941	c.676_678delAAG	c.(676-678)AAGdel	p.K226del	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	226	Basic motif.				negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				TCACGTACTCCTTCTTCTTCAGT	0.384											OREG0021274	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	85375244	-	-	85375242	7	5	14	1	0	1	0	1	0	0	0	0	3863	680	24	0	390	0	CREBZF	11	85375242	In_Frame_Del	DEL	CTT	TCGA-06-0129-01A-01D-1490-08	22379283	85375242	49631274	28	1000											
EXPH5	23086	broad.mit.edu	37	chr11	108382300	108382300	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gacggacatctttagattttCacatgaaggtgttcctgact	9	8	2	3			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr11:108382300C>T	uc001pkk.2	-	6	4045	c.3934G>A	c.(3934-3936)GAA>AAA	p.E1312K	EXPH5_uc010rvy.1_Missense_Mutation_p.E1124K|EXPH5_uc010rvz.1_Missense_Mutation_p.E1156K|EXPH5_uc010rwa.1_Missense_Mutation_p.E1236K	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1312					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTTAGATTTTCACATGAAGGT	0.413													T	108382300	T	T	108382300	3	4	14	1	0	0	0	0	1	0	0	0	5322	835	29	3	2039	3	EXPH5	11	108382300	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	23007058	108382300	26624216	29	1001											
C12orf11	55726	broad.mit.edu	37	chr12	27059333	27059333	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tttctggaattggcagtattGattctattactccacaagga	8	7	2	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr12:27059333G>T	uc001rhk.3	-	16	2520	c.1983C>A	c.(1981-1983)ATC>ATA	p.I661I	C12orf11_uc001rhj.3_Silent_p.I229I|C12orf11_uc010sjk.1_Silent_p.I560I	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	661					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					TGGCAGTATTGATTCTATTAC	0.308													T	27059333	T	T	27059333	2	4	14	1	0	0	0	0	0	0	0	1	1675	1280	45	5		5	C12orf11	12	27059333	Silent	SNP	G	TCGA-06-0129-01A-01D-1490-08		27059333	106792562	30	1002											
LRRK2	120892	broad.mit.edu	37	chr12	40668431	40668431	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atgtggattaaaagtaatttCttctattgtacattttcctg	6	5	2	0			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr12:40668431C>G	uc001rmg.3	+	15	1824	c.1703C>G	c.(1702-1704)TCT>TGT	p.S568C	LRRK2_uc001rmh.1_Missense_Mutation_p.S190C	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	568					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AAAGTAATTTCTTCTATTGTA	0.358													G	40668431	G	G	40668431	3	3	14	1	0	0	0	0	1	0	0	0	9033	913	32	5	1761	5	LRRK2	12	40668431	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	13609098	40668431	93183464	31	1003											
ANKRD52	283373	broad.mit.edu	37	chr12	56638930	56638930	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggggtttccttccaggtacgAaaacgggctgtgttcaagta	13	8	1	0			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr12:56638930A>G	uc001skm.3	-	22	2539	c.2449T>C	c.(2449-2451)TCG>CCG	p.S817P		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	817	ANK 23.						protein binding			ovary(2)	2						TCCAGGTACGAAAACGGGCTG	0.522													G	56638930	G	G	56638930	3	3	14	1	0	0	0	0	1	0	0	0	678	246	9	4	809	4	ANKRD52	12	56638930	Missense_Mutation	SNP	A	TCGA-06-0129-01A-01D-1490-08	15970499	56638930	77212965	32	1004											
ANKRD52	283373	broad.mit.edu	37	chr12	56639372	56639372	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccaggcagtcctcacagccAgtcactgcctgtgagtaaca	10	14	2	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr12:56639372A>C	uc001skm.3	-	21	2283	c.2193T>G	c.(2191-2193)ACT>ACG	p.T731T		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	731	ANK 21.						protein binding			ovary(2)	2						CCTCACAGCCAGTCACTGCCT	0.587													C	56639372	C	C	56639372	2	2	14	1	0	0	0	0	0	0	0	1	678	175	7	5		5	ANKRD52	12	56639372	Silent	SNP	A	TCGA-06-0129-01A-01D-1490-08	442	56639372	77212523	33	1005											
IL22	50616	broad.mit.edu	37	chr12	68647046	68647046	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggattgagatgtatacctcCttagccagcatgaaggtgcg	12	8	0	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr12:68647046C>G	uc001sty.1	-	1	236	c.183G>C	c.(181-183)AAG>AAC	p.K61N	IL22_uc010stb.1_Missense_Mutation_p.K61N	NM_020525	NP_065386	Q9GZX6	IL22_HUMAN	interleukin 22 precursor	61					acute-phase response	extracellular space	cytokine activity|interleukin-22 receptor binding				0		Myeloproliferative disorder(1001;0.0255)	Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;5.06e-05)|BRCA - Breast invasive adenocarcinoma(357;0.00104)		TGTATACCTCCTTAGCCAGCA	0.483													G	68647046	G	G	68647046	3	3	14	1	0	0	0	0	1	0	0	0	7672	680	24	5	376	5	IL22	12	68647046	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	12007674	68647046	65204849	34	1006											
RPLP0	6175	broad.mit.edu	37	chr12	120636422	120636422	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcagggttgtagatgctgcCattgtcgaacacctgctgga	12	9	1	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr12:120636422C>T	uc001txp.2	-	6	823	c.586G>A	c.(586-588)GGC>AGC	p.G196S	RPLP0_uc001txq.2_Missense_Mutation_p.G196S|RPLP0_uc001txr.2_Intron|uc001txs.1_5'Flank	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	196					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAGATGCTGCCATTGTCGAAC	0.532													T	120636422	T	T	120636422	3	4	14	1	0	0	0	0	1	0	0	0	13604	594	21	3	379	3	RPLP0	12	120636422	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	51989376	120636422	13215473	35	1007											
HIP1R	9026	broad.mit.edu	37	chr12	123346052	123346052	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccagcgtggcccccagacaGgaccaccaggtgccgtctgc	12	18	1	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr12:123346052G>A	uc001udj.1	+	31	3209	c.3150G>A	c.(3148-3150)CAG>CAA	p.Q1050Q	HIP1R_uc001udk.1_Silent_p.Q315Q	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	1050					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CCCCCAGACAGGACCACCAGG	0.677													A	123346052	A	A	123346052	2	1	14	1	0	0	0	0	0	0	0	1	7115	991	35	3		3	HIP1R	12	123346052	Silent	SNP	G	TCGA-06-0129-01A-01D-1490-08	2709630	123346052	10505843	36	1008											
NALCN	259232	broad.mit.edu	37	chr13	102047697	102047697	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctgatgatggcacagatgCgcagcaaagagtgaacccac	12	11	0	5			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr13:102047697C>T	uc001vox.1	-	3	317	c.128G>A	c.(127-129)CGC>CAC	p.R43H	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.R43H|NALCN_uc001vpa.2_Missense_Mutation_p.R43H	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	43	Helical; Name=S1 of repeat I; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGCACAGATGCGCAGCAAAGA	0.433													T	102047697	T	T	102047697	3	4	14	1	0	0	0	0	1	0	0	0	10148	768	27	1	5256	1	NALCN	13	102047697	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08		102047697	13122181	37	1009											
OR4N2	390429	broad.mit.edu	37	chr14	20295961	20295961	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggattactccttgttgtgatGgcctttgaccgctacatcgc	10	11	0	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr14:20295961G>A	uc010tkv.1	+	1	354	c.354G>A	c.(352-354)ATG>ATA	p.M118I		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTGTTGTGATGGCCTTTGACC	0.517													A	20295961	A	A	20295961	3	1	14	1	0	0	0	0	1	0	0	0	11077	1348	47	3	356	3	OR4N2	14	20295961	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08		20295961	87053579	38	1010											
MIA2	117153	broad.mit.edu	37	chr14	39703346	39703348	+	In_Frame_Del	DEL	CTT	-	-													aatttggcgttcacagaatcCttcttctggctatttctctg							TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr14:39703346_39703348delCTT	uc001wux.2	+	1	222_224	c.28_30delCTT	c.(28-30)CTTdel	p.L12del	MIA2_uc010amy.1_5'UTR	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	12						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		TCACAGAATCCTTCTTCTGGCTA	0.424													-	39703348	-	-	39703346	7	5	14	1	0	1	0	1	0	0	0	0	9564	681	24	0	30	0	MIA2	14	39703346	In_Frame_Del	DEL	CTT	TCGA-06-0129-01A-01D-1490-08	19407385	39703346	67646194	39	1011											
DHX38	9785	broad.mit.edu	37	chr16	72130894	72130894	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgggatcgagactatgaccGcaagagggacagaggtaaac	15	8	0	4			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr16:72130894G>A	uc002fcb.2	+	3	852	c.497G>A	c.(496-498)CGC>CAC	p.R166H	TXNL4B_uc010vmo.1_5'Flank|DHX38_uc010vmp.1_Intron|DHX38_uc010cgn.1_RNA	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	166					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				GACTATGACCGCAAGAGGGAC	0.488													A	72130894	A	A	72130894	3	1	14	1	0	0	0	0	1	0	0	0	4511	1087	38	1	503	1	DHX38	16	72130894	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08		72130894	18223859	40	1012											
OR3A1	4994	broad.mit.edu	37	chr17	3195464	3195464	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggactgtctgactcatgCgggtgctgtaggtgaggggc	17	8	3	2	rs143631940		TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr17:3195464C>T	uc002fvh.1	-	1	413	c.413G>A	c.(412-414)CGC>CAC	p.R138H		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						CTGACTCATGCGGGTGCTGTA	0.582													T	3195464	T	T	3195464	3	4	14	1	0	0	0	0	1	0	0	0	11037	768	27	1	538	1	OR3A1	17	3195464	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08		3195464	77999746	41	1013											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577538	T	T	7577538	3	4	14	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	4382074	7577538	73617672	42	1014											
CALR3	125972	broad.mit.edu	37	chr19	16593572	16593572	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctctgcttgctggtgctggCgtccagaaaatgcttctccc	11	13	2	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr19:16593572C>T	uc002ned.2	-	6	766	c.703G>A	c.(703-705)GCC>ACC	p.A235T	MED26_uc002nee.2_RNA	NM_145046	NP_659483	Q96L12	CALR3_HUMAN	calreticulin 3 precursor	235	4 X approximate repeats.|P-domain.|1-4.				protein folding	endoplasmic reticulum lumen	calcium ion binding|sugar binding|unfolded protein binding				0						CTGGTGCTGGCGTCCAGAAAA	0.458													T	16593572	T	T	16593572	3	4	14	1	0	0	0	0	1	0	0	0	2593	768	27	1	467	1	CALR3	19	16593572	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08		16593572	42535411	43	1015											
ZNF790	388536	broad.mit.edu	37	chr19	37310870	37310870	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atcttgaagtgtttgaaactGagtgttgccttcccagtcac	9	9	2	3			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr19:37310870G>A	uc002oew.2	-	5	495	c.376C>T	c.(376-378)CAG>TAG	p.Q126*	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GTTTGAAACTGAGTGTTGCCT	0.383													A	37310870	A	A	37310870	4	1	14	1	0	0	0	0	0	1	0	0	18159	1299	45	3	1538	3	ZNF790	19	37310870	Nonsense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08	20717298	37310870	21818113	44	1016											
SIGLEC6	946	broad.mit.edu	37	chr19	52033694	52033694	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactggctggttcctacctgCgctgtttccttggaagatgc	12	11	0	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr19:52033694C>T	uc002pwy.2	-	4	913	c.751G>A	c.(751-753)GCA>ACA	p.A251T	SIGLEC6_uc002pwz.2_Intron|SIGLEC6_uc002pxa.2_Missense_Mutation_p.A251T|SIGLEC6_uc010ydb.1_Intron|SIGLEC6_uc010ydc.1_Missense_Mutation_p.A251T|SIGLEC6_uc010eoz.1_Missense_Mutation_p.A229T|SIGLEC6_uc010epb.1_Missense_Mutation_p.A204T|SIGLEC6_uc010epa.1_Missense_Mutation_p.A240T	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	251	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TTCCTACCTGCGCTGTTTCCT	0.562													T	52033694	T	T	52033694	3	4	14	1	0	0	0	0	1	0	0	0	14312	768	27	1	630	1	SIGLEC6	19	52033694	Missense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08	14722824	52033694	7095289	45	1017											
DEFB125	245938	broad.mit.edu	37	chr20	77035	77035	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agactatgccaccaccttctCagacagctcttactcataat	4	14	3	2			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr20:77035C>T	uc002wcw.2	+	2	448	c.448C>T	c.(448-450)CAG>TAG	p.Q150*		NM_153325	NP_697020	Q8N687	DB125_HUMAN	defensin, beta 125 preproprotein	150					defense response to bacterium	extracellular region				ovary(1)|central_nervous_system(1)|skin(1)	3		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.156)			ACCACCTTCTCAGACAGCTCT	0.428													T	77035	T	T	77035	4	4	14	1	0	0	0	0	0	1	0	0	4411	827	29	3	454	3	DEFB125	20	77035	Nonsense_Mutation	SNP	C	TCGA-06-0129-01A-01D-1490-08		77035	62948485	46	1018											
ZNF343	79175	broad.mit.edu	37	chr20	2464182	2464182	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaaggaggagtgatttccgActaaagcctcggccacactc	10	12	0	1			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr20:2464182A>G	uc002wge.1	-	6	1913	c.1425T>C	c.(1423-1425)AGT>AGC	p.S475S	ZNF343_uc010gao.1_Silent_p.S475S|ZNF343_uc002wgd.1_Silent_p.S385S	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	475	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GTGATTTCCGACTAAAGCCTC	0.527													G	2464182	G	G	2464182	2	3	14	1	0	0	0	0	0	0	0	1	17855	272	10	4		4	ZNF343	20	2464182	Silent	SNP	A	TCGA-06-0129-01A-01D-1490-08	2387147	2464182	60561338	47	1019											
CEP250	11190	broad.mit.edu	37	chr20	34084435	34084436	+	Frame_Shift_Del	DEL	AG	-	-													gtcactgatggaaaaggaacAgagactccttgttttacaag							TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr20:34084435_34084436delAG	uc002xcm.2	+	26	3868_3869	c.3197_3198delAG	c.(3196-3198)CAGfs	p.Q1066fs	CEP250_uc010zve.1_Frame_Shift_Del_p.Q434fs	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1066	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GAAAAGGAACAGAGACTCCTTG	0.48													-	34084436	-	-	34084435	7	5	14	1	0	1	0	1	0	0	0	0	3252	188	7	0	3283	0	CEP250	20	34084435	Frame_Shift_Del	DEL	AG	TCGA-06-0129-01A-01D-1490-08	31620253	34084435	28941085	48	1020											
HMOX1	3162	broad.mit.edu	37	chr22	35783113	35783113	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actccctggagatgactcccGcagtcaggcagagggtgata	13	11	1	4			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr22:35783113G>A	uc003ant.1	+	3	660	c.580G>A	c.(580-582)GCA>ACA	p.A194T		NM_002133	NP_002124	P09601	HMOX1_HUMAN	heme oxygenase (decyclizing) 1	194					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			ovary(1)	1					NADH(DB00157)	GATGACTCCCGCAGTCAGGCA	0.622													A	35783113	A	A	35783113	3	1	14	1	0	0	0	0	1	0	0	0	7243	1087	38	1	590	1	HMOX1	22	35783113	Missense_Mutation	SNP	G	TCGA-06-0129-01A-01D-1490-08		35783113	15521453	49	1021											
MYH9	4627	broad.mit.edu	37	chr22	36745230	36745232	+	In_Frame_Del	DEL	TGA	-	-													ggcctgggccagcggattgtTgatgaagtttttatccacat							TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chr22:36745230_36745232delTGA	uc003apg.2	-	2	281_283	c.50_52delTCA	c.(49-54)ATCAAC>AAC	p.I17del	MYH9_uc003api.1_In_Frame_Del_p.I17del	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	17	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						AGCGGATTGTTGATGAAGTTTTT	0.542			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				-	36745232	-	-	36745230	7	5	14	1	0	1	0	1	0	0	0	0	10042	1812	63	0	5990	0	MYH9	22	36745230	In_Frame_Del	DEL	TGA	TCGA-06-0129-01A-01D-1490-08	962117	36745230	14559336	50	1022											
P2RY8	286530	broad.mit.edu	37	chrX	1584564	1584564	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcagctggaattcccgggaCgcaaagtaataaacaaacgg	11	10	0	0			TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chrX:1584564C>T	uc004cpz.2	-	2	1136	c.888G>A	c.(886-888)GCG>GCA	p.A296A		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	296	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATTCCCGGGACGCAAAGTAAT	0.602			T	CRLF2	B-ALL|Downs associated ALL								T	1584564	T	T	1584564	2	4	14	1	0	0	0	0	0	0	0	1	11355	523	19	1		1	P2RY8	23	1584564	Silent	SNP	C	TCGA-06-0129-01A-01D-1490-08		1584564	153685996	51	1023											
ATRX	546	broad.mit.edu	37	chrX	76938089	76938092	+	Frame_Shift_Del	DEL	TCTC	-	-													gccttctgctgaagagaaagTctctctctcttgttttcttt					rs141180098		TCGA-06-0129-01A-01D-1490-08	TCGA-06-0129-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	73e7aa35-91b4-4392-bbb9-9ec21f30250c	9b321fd2-a9f5-4cb0-9a18-2dc271056285	g.chrX:76938089_76938092delTCTC	uc004ecp.3	-	9	2888_2891	c.2656_2659delGAGA	c.(2656-2661)GAGACTfs	p.E886fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.E848fs|ATRX_uc004eco.3_Frame_Shift_Del_p.E671fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.E818fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.E857fs|ATRX_uc010nly.1_Frame_Shift_Del_p.E831fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	886_887					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GAAGAGAAAGTCTCTCTCTCTTGT	0.412			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						-	76938092	-	-	76938089	7	5	14	1	0	1	0	1	0	0	0	0	1208	1667	58	0	4927	0	ATRX	23	76938089	Frame_Shift_Del	DEL	TCTC	TCGA-06-0129-01A-01D-1490-08	75353525	76938089	78332471	52	1024											
CLCN6	1185	broad.mit.edu	37	chr1	11897130	11897130	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aagtcctacccatccagcgaGctacggaacatgtgtgatga	10	11	0	2	rs137976806		TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr1:11897130G>C	uc001ate.3	+	19	2168	c.2055G>C	c.(2053-2055)GAG>GAC	p.E685D	CLCN6_uc010oat.1_Missense_Mutation_p.E401D|CLCN6_uc010oau.1_Missense_Mutation_p.E663D	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	685	Cytoplasmic (By similarity).				cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CATCCAGCGAGCTACGGAACA	0.622													C	11897130	C	C	11897130	3	2	15	1	0	0	0	0	1	0	0	0	3467	962	34	5	2139	5	CLCN6	1	11897130	Missense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08		11897130	237353491	1	1025											
CSMD2	114784	broad.mit.edu	37	chr1	34035009	34035009	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagagccactccagagcccaTtggccatgcactcacgcacc	8	18	1	2	rs143469891	byFrequency	TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr1:34035009T>C	uc001bxn.1	-	53	8131	c.8102A>G	c.(8101-8103)AAT>AGT	p.N2701S	CSMD2_uc001bxm.1_Missense_Mutation_p.N2699S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2701	Sushi 17.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCAGAGCCCATTGGCCATGCA	0.547													C	34035009	C	C	34035009	3	2	15	1	0	0	0	0	1	0	0	0	3945	1493	52	4	2429	4	CSMD2	1	34035009	Missense_Mutation	SNP	T	TCGA-06-0130-01A-01D-1490-08	22137879	34035009	215215612	2	1026											
ZC3H12A	80149	broad.mit.edu	37	chr1	37948728	37948728	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggattgcctggactcggGcattggctccctggagagcc	14	13	0	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr1:37948728G>A	uc001cbb.3	+	6	1466	c.1316G>A	c.(1315-1317)GGC>GAC	p.G439D	ZC3H12A_uc001cbc.1_Missense_Mutation_p.G234D	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	439					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTGGACTCGGGCATTGGCTCC	0.662													A	37948728	A	A	37948728	3	1	15	1	0	0	0	0	1	0	0	0	17558	1203	42	3	1334	3	ZC3H12A	1	37948728	Missense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08	3913719	37948728	211301893	3	1027											
CACNA1E	777	broad.mit.edu	37	chr1	181700365	181700365	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgggagccacgcagcagccaCctgtatgtgtgtaccagttt	12	11	0	0			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr1:181700365C>A	uc001gow.2	+	19	2460	c.2295C>A	c.(2293-2295)CAC>CAA	p.H765Q	CACNA1E_uc009wxs.2_Intron|CACNA1E_uc001gox.1_5'Flank|CACNA1E_uc009wxt.2_5'Flank	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	765	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GCAGCAGCCACCTGTATGTGT	0.522													A	181700365	A	A	181700365	3	1	15	1	0	0	0	0	1	0	0	0	2542	506	18	5	2369	5	CACNA1E	1	181700365	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08	143751637	181700365	67550256	4	1028											
TTN	7273	broad.mit.edu	37	chr2	179458768	179458768	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtatttgccggaatctgaaCgtttggccttgatcttctct	9	9	3	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr2:179458768C>T	uc010zfg.1	-	246	50872	c.50648G>A	c.(50647-50649)CGT>CAT	p.R16883H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R10578H|TTN_uc010zfi.1_Missense_Mutation_p.R10511H|TTN_uc010zfj.1_Missense_Mutation_p.R10386H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17810							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAATCTGAACGTTTGGCCTT	0.418													T	179458768	T	T	179458768	3	4	15	1	0	0	0	0	1	0	0	0	16732	536	19	1	49891	1	TTN	2	179458768	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08		179458768	63740605	5	1029											
SF3B1	23451	broad.mit.edu	37	chr2	198267698	198267698	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccaaattagaaatgatctctCggccttccactctagcatag	6	12	2	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr2:198267698C>T	uc002uue.2	-	13	1829	c.1781G>A	c.(1780-1782)CGA>CAA	p.R594Q		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	594	HEAT 2.			R -> L (in Ref. 1; AAC97189).	nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AATGATCTCTCGGCCTTCCAC	0.338													T	198267698	T	T	198267698	3	4	15	1	0	0	0	0	1	0	0	0	14149	884	31	2	2185	2	SF3B1	2	198267698	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08	18808930	198267698	44931675	6	1030											
PLCD1	5333	broad.mit.edu	37	chr3	38052749	38052749	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caatgagggagagggccagcGcaggccctgccgcctcctcc	14	16	0	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr3:38052749G>A	uc003chn.2	-	5	870	c.746C>T	c.(745-747)GCG>GTG	p.A249V	PLCD1_uc003chm.2_Missense_Mutation_p.A270V	NM_006225	NP_006216	P51178	PLCD1_HUMAN	phospholipase C, delta 1 isoform 2	249					intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		GAGGGCCAGCGCAGGCCCTGC	0.687													A	38052749	A	A	38052749	3	1	15	1	0	0	0	0	1	0	0	0	12031	1087	38	1	1568	1	PLCD1	3	38052749	Missense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08		38052749	159969681	7	1031											
CX3CR1	1524	broad.mit.edu	37	chr3	39307436	39307436	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtttccacattgcggagcaCgggccagatttcctggagga	13	10	0	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr3:39307436C>T	uc003cjl.2	-	2	657	c.565G>A	c.(565-567)GTG>ATG	p.V189M		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	189	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		TTGCGGAGCACGGGCCAGATT	0.483													T	39307436	T	T	39307436	3	4	15	1	0	0	0	0	1	0	0	0	4075	536	19	1	506	1	CX3CR1	3	39307436	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08	1254687	39307436	158714994	8	1032											
CLEC3B	7123	broad.mit.edu	37	chr3	45077251	45077251	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcacctgggtggacatgacCggcgcccgcatcgcctacaa	13	15	0	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr3:45077251C>T	uc003cok.3	+	3	540	c.444C>T	c.(442-444)ACC>ACT	p.T148T	CLEC3B_uc003col.2_Silent_p.T106T	NM_003278	NP_003269	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	148	C-type lectin.				skeletal system development	extracellular space	protein binding|sugar binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGACATGACCGGCGCCCGCA	0.667													T	45077251	T	T	45077251	2	4	15	1	0	0	0	0	0	0	0	1	3511	639	23	2		2	CLEC3B	3	45077251	Silent	SNP	C	TCGA-06-0130-01A-01D-1490-08	5769815	45077251	152945179	9	1033											
ARMC8	25852	broad.mit.edu	37	chr3	137991889	137991889	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaacagctattccggttattAtcagattcagatttgaatgt	8	6	2	3			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr3:137991889A>G	uc003esa.1	+	18	1885	c.1518A>G	c.(1516-1518)TTA>TTG	p.L506L	TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Intron|TXNDC6_uc003ese.1_Intron|ARMC8_uc011bmf.1_Silent_p.L489L|ARMC8_uc011bmg.1_Silent_p.L453L|ARMC8_uc011bmh.1_Silent_p.L447L|ARMC8_uc003esb.1_Silent_p.L478L|ARMC8_uc003esc.1_Silent_p.L278L|ARMC8_uc003esf.1_Silent_p.L89L	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	520	ARM 11.						binding				0						TCCGGTTATTATCAGATTCAG	0.368													G	137991889	G	G	137991889	2	3	15	1	0	0	0	0	0	0	0	1	957	446	16	4		4	ARMC8	3	137991889	Silent	SNP	A	TCGA-06-0130-01A-01D-1490-08	92914638	137991889	60030541	10	1034											
TEC	7006	broad.mit.edu	37	chr4	48140944	48140944	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaccagacatctgatttgCtgctgaagcggctgtaatta	10	8	1	4			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr4:48140944C>T	uc003gxz.2	-	16	1722	c.1631G>A	c.(1630-1632)AGC>AAC	p.S544N		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	544	Protein kinase.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						ATCTGATTTGCTGCTGAAGCG	0.438													T	48140944	T	T	48140944	3	4	15	1	0	0	0	0	1	0	0	0	15739	797	28	3	276	3	TEC	4	48140944	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08		48140944	143013332	11	1035											
KIAA0922	23240	broad.mit.edu	37	chr4	154517485	154517485	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaaatgaaaagggttggcGtagttttcacacctgctgac	12	7	1	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr4:154517485G>A	uc003inm.3	+	20	2120	c.2068G>A	c.(2068-2070)GTA>ATA	p.V690I	KIAA0922_uc010ipp.2_Missense_Mutation_p.V691I|KIAA0922_uc010ipq.2_Missense_Mutation_p.V459I	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	690	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				AAGGGTTGGCGTAGTTTTCAC	0.423													A	154517485	A	A	154517485	3	1	15	1	0	0	0	0	1	0	0	0	8201	1145	40	1	2149	1	KIAA0922	4	154517485	Missense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08	106376541	154517485	36636791	12	1036											
C5orf36	285600	broad.mit.edu	37	chr5	93856069	93856069	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caagaaattttgccatttctTctgtaacagtatccaggtaa	6	8	2	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr5:93856069T>G	uc011cuk.1	-	5	1111	c.854A>C	c.(853-855)GAA>GCA	p.E285A	C5orf36_uc003kkp.2_Missense_Mutation_p.E285A	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	285											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		TGCCATTTCTTCTGTAACAGT	0.348													G	93856069	G	G	93856069	3	3	15	1	0	0	0	0	1	0	0	0	2295	1783	62	5	3046	5	C5orf36	5	93856069	Missense_Mutation	SNP	T	TCGA-06-0130-01A-01D-1490-08		93856069	87059191	13	1037											
CYP21A2	1589	broad.mit.edu	37	chr6	32006249	32006249	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccctgctggctggcgcccGcctgctgtggaactggtgga	16	14	0	0			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr6:32006249G>A	uc003nze.1	+	1	168	c.50G>A	c.(49-51)CGC>CAC	p.R17H	CYP21A2_uc003nzf.1_Missense_Mutation_p.R17H	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	16					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						GCTGGCGCCCGCCTGCTGTGG	0.542													A	32006249	A	A	32006249	3	1	15	1	0	0	0	0	1	0	0	0	4153	1087	38	1	1573	1	CYP21A2	6	32006249	Missense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08		32006249	139108818	14	1038											
COL12A1	1303	broad.mit.edu	37	chr6	75797410	75797410	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acggccaggggggccaggggGacctcttgaacctgtggacc	17	12	1	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr6:75797410G>A	uc003phs.2	-	65	9230	c.9064C>T	c.(9064-9066)CCC>TCC	p.P3022S	COL12A1_uc003pht.2_Missense_Mutation_p.P1858S	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	3022	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GGGCCAGGGGGACCTCTTGAA	0.522													A	75797410	A	A	75797410	3	1	15	1	0	0	0	0	1	0	0	0	3669	1174	41	3	135	3	COL12A1	6	75797410	Missense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08	43791161	75797410	95317657	15	1039											
MEST	4232	broad.mit.edu	37	chr7	130139717	130139717	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agataagtctcttctacaggTatctttcctgagactcaccg	7	11	4	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr7:130139717T>A	uc003vqg.2	+	7	754	c.537T>A	c.(535-537)GGT>GGA	p.G179G	MEST_uc003vqc.2_Silent_p.G170G|MEST_uc003vqd.2_Silent_p.G170G|MEST_uc003vqf.2_Silent_p.G170G|MEST_uc011kph.1_Silent_p.G165G|MEST_uc010lmg.2_Silent_p.G179G	NM_002402	NP_002393	Q5EB52	MEST_HUMAN	mesoderm specific transcript isoform a	179					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)					CTTCTACAGGTATCTTTCCTG	0.284													A	130139717	A	A	130139717	2	1	15	1	0	0	0	0	0	0	0	1	9484	1652	57	5		5	MEST	7	130139717	Silent	SNP	T	TCGA-06-0130-01A-01D-1490-08		130139717	28998946	16	1040											
OR2F2	135948	broad.mit.edu	37	chr7	143632696	143632696	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatggcctatgaccgccatgTggctgtgtctgaccgcctgc	13	13	1	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr7:143632696T>G	uc011ktv.1	+	1	371	c.371T>G	c.(370-372)GTG>GGG	p.V124G		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					GACCGCCATGTGGCTGTGTCT	0.562													G	143632696	G	G	143632696	3	3	15	1	0	0	0	0	1	0	0	0	10997	1696	59	5	373	5	OR2F2	7	143632696	Missense_Mutation	SNP	T	TCGA-06-0130-01A-01D-1490-08	13492979	143632696	15505967	17	1041											
FBXO32	114907	broad.mit.edu	37	chr8	124518764	124518764	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctcagcctctgcatgatgttCagttgtaggcacaaaggcag	11	10	3	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr8:124518764C>T	uc003yqr.2	-	7	894	c.702G>A	c.(700-702)CTG>CTA	p.L234L	FBXO32_uc003yqq.2_Silent_p.L89L|FBXO32_uc010mdk.2_Silent_p.L141L	NM_058229	NP_478136	Q969P5	FBX32_HUMAN	F-box only protein 32 isoform 1	234	F-box.									skin(3)|breast(2)|lung(1)	6	Lung NSC(37;1.13e-13)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GCATGATGTTCAGTTGTAGGC	0.622													T	124518764	T	T	124518764	2	4	15	1	0	0	0	0	0	0	0	1	5742	813	29	3		3	FBXO32	8	124518764	Silent	SNP	C	TCGA-06-0130-01A-01D-1490-08		124518764	21845258	18	1042											
TEK	7010	broad.mit.edu	37	chr9	27206739	27206739	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggccaagttcttaaggcgCgcatcaagaaggatgggtta	13	7	2	1	rs147231791	by1000genomes	TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr9:27206739C>T	uc003zqi.3	+	15	2966	c.2524C>T	c.(2524-2526)CGC>TGC	p.R842C	TEK_uc011lno.1_Missense_Mutation_p.R799C|TEK_uc011lnp.1_Missense_Mutation_p.R694C|TEK_uc003zqj.1_Missense_Mutation_p.R776C	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	842	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TCTTAAGGCGCGCATCAAGAA	0.453													T	27206739	T	T	27206739	3	4	15	1	0	0	0	0	1	0	0	0	15748	768	27	1	2582	1	TEK	9	27206739	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08		27206739	114006692	19	1043											
FLJ46321	389763	broad.mit.edu	37	chr9	84607173	84607173	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccctactacctagtcctctAttcctgattaggatctgtgg	8	12	2	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr9:84607173A>G	uc004amn.2	+	4	1835	c.1788A>G	c.(1786-1788)CTA>CTG	p.L596L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	596						integral to membrane					0						CTAGTCCTCTATTCCTGATTA	0.512													G	84607173	G	G	84607173	2	3	15	1	0	0	0	0	0	0	0	1	5932	436	16	4		4	FLJ46321	9	84607173	Silent	SNP	A	TCGA-06-0130-01A-01D-1490-08	57400434	84607173	56606258	20	1044											
OR4C6	219432	broad.mit.edu	37	chr11	55433335	55433335	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttacagctctaaagggcgGcacaaagccctctctacctg	8	14	3	0			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr11:55433335G>A	uc001nht.3	+	3	958	c.693G>A	c.(691-693)CGG>CGA	p.R231R	OR4C6_uc010rik.1_Silent_p.R231R	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CTAAAGGGCGGCACAAAGCCC	0.507													A	55433335	A	A	55433335	2	1	15	1	0	0	0	0	0	0	0	1	11052	1190	42	3		3	OR4C6	11	55433335	Silent	SNP	G	TCGA-06-0130-01A-01D-1490-08		55433335	79573181	21	1045											
HELB	92797	broad.mit.edu	37	chr12	66725048	66725048	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gagtgtatgtgattgcagagGagtctcagctccggaatgcc	14	8	1	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr12:66725048G>T	uc001sti.2	+	12	2813	c.2785G>T	c.(2785-2787)GAG>TAG	p.E929*	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	929					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		GATTGCAGAGGAGTCTCAGCT	0.532													T	66725048	T	T	66725048	4	4	15	1	0	0	0	0	0	1	0	0	7045	1175	41	5	2831	5	HELB	12	66725048	Nonsense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08		66725048	67126847	22	1046											
RB1	5925	broad.mit.edu	37	chr13	49039505	49039505	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaaatgactccaagatcaagGtgtgtgttttctctttaggg	10	6	2	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr13:49039505G>T	uc001vcb.2	+	23	2655	c.2489_splice	c.e23+1	p.R830_splice		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAAGATCAAGGTGTGTGTTTT	0.358		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	49039505	T	T	49039505	5	4	15	1	0	0	0	0	0	0	1	0	13098	1275	44	5	2580	5	RB1	13	49039505	Splice_Site	SNP	G	TCGA-06-0130-01A-01D-1490-08		49039505	66130373	23	1047											
C14orf37	145407	broad.mit.edu	37	chr14	58605421	58605421	+	Frame_Shift_Del	DEL	T	-	-													caaatttctcagtctttggaTtggtggttagcatttcctta							TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr14:58605421delT	uc001xdc.2	-	2	767	c.656delA	c.(655-657)AATfs	p.N219fs	C14orf37_uc010tro.1_Frame_Shift_Del_p.N257fs|C14orf37_uc001xdd.2_Frame_Shift_Del_p.N219fs|C14orf37_uc001xde.2_Frame_Shift_Del_p.N219fs	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	219	Extracellular (Potential).					integral to membrane	binding				0						AGTCTTTGGATTGGTGGTTAG	0.448													-	58605421	-	-	58605421	7	5	15	1	0	1	0	1	0	0	0	0	1771	1493	52	0	1696	0	C14orf37	14	58605421	Frame_Shift_Del	DEL	T	TCGA-06-0130-01A-01D-1490-08		58605421	48744119	24	1048											
ZSCAN29	146050	broad.mit.edu	37	chr15	43658653	43658653	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgacactgttccagggtccGgaggaagccatattccctga	11	13	0	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr15:43658653G>A	uc001zrk.1	-	3	1024	c.877C>T	c.(877-879)CGG>TGG	p.R293W	ZSCAN29_uc001zrj.1_Missense_Mutation_p.R173W|ZSCAN29_uc010bdf.1_Missense_Mutation_p.R292W|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Intron|ZSCAN29_uc001zrm.2_Missense_Mutation_p.R292W	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	293					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		TCCAGGGTCCGGAGGAAGCCA	0.542													A	43658653	A	A	43658653	3	1	15	1	0	0	0	0	1	0	0	0	18233	1115	39	2	1693	2	ZSCAN29	15	43658653	Missense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08		43658653	58872739	25	1049											
FANCI	55215	broad.mit.edu	37	chr15	89859689	89859689	+	Nonstop_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caagaagaaaaggaaaaaatAaatgaaatgcctgagttaat	8	3	0	4			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr15:89859689A>C	uc010bnp.1	+	38	4076	c.3986A>C	c.(3985-3987)TAA>TCA	p.*1329S	FANCI_uc002bnm.1_Nonstop_Mutation_p.*1269S|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Nonstop_Mutation_p.*1089S|FANCI_uc002bnq.1_Nonstop_Mutation_p.*742S|POLG_uc002bns.3_3'UTR|POLG_uc002bnr.3_3'UTR	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1329					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					AGGAAAAAATAAATGAAATGC	0.438								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				C	89859689	C	C	89859689	4	2	15	1	0	0	0	0	0	0	0	0	5669	369	13	5	4132	5	FANCI	15	89859689	Nonstop_Mutation	SNP	A	TCGA-06-0130-01A-01D-1490-08	46201036	89859689	12671703	26	1050											
CHST5	23563	broad.mit.edu	37	chr16	75563927	75563927	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcgcacaaaaagatagagCgcatcaggtcgcgcacggcc	12	12	1	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr16:75563927C>T	uc002fei.2	-	3	1751	c.356G>A	c.(355-357)CGC>CAC	p.R119H	CHST5_uc002fej.1_Missense_Mutation_p.R125H	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	119	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						AAAGATAGAGCGCATCAGGTC	0.617													T	75563927	T	T	75563927	3	4	15	1	0	0	0	0	1	0	0	0	3407	768	27	1	883	1	CHST5	16	75563927	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08		75563927	14790826	27	1051											
KARS	3735	broad.mit.edu	37	chr16	75670442	75670442	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagctcttttggcatggatcCtacctagaaaaagaagagca	9	8	1	3			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr16:75670442C>G	uc002feq.2	-	4	440	c.392G>C	c.(391-393)AGG>ACG	p.R131T	KARS_uc002fer.2_Missense_Mutation_p.R159T|KARS_uc002fes.2_5'UTR|KARS_uc010cgz.2_5'UTR	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	131					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	GGCATGGATCCTACCTAGAAA	0.403													G	75670442	G	G	75670442	3	3	15	1	0	0	0	0	1	0	0	0	7980	681	24	5	1445	5	KARS	16	75670442	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08	106515	75670442	14684311	28	1052											
TP53	7157	broad.mit.edu	37	chr17	7578457	7578457	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttgtagatggccatggcgCggacgcgggtgccgggcggg	21	10	0	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr17:7578457C>T	uc002gim.2	-	5	667	c.473G>A	c.(472-474)CGC>CAC	p.R158H	TP53_uc002gig.1_Missense_Mutation_p.R158H|TP53_uc002gih.2_Missense_Mutation_p.R158H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26H|TP53_uc010cng.1_Missense_Mutation_p.R26H|TP53_uc002gii.1_Missense_Mutation_p.R26H|TP53_uc010cnh.1_Missense_Mutation_p.R158H|TP53_uc010cni.1_Missense_Mutation_p.R158H|TP53_uc002gij.2_Missense_Mutation_p.R158H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65H|TP53_uc002gio.2_Missense_Mutation_p.R26H|TP53_uc010vug.1_Missense_Mutation_p.R119H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578457	T	T	7578457	3	4	15	1	0	0	0	0	1	0	0	0	16378	768	27	1	825	1	TP53	17	7578457	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08		7578457	73616753	29	1053											
CYP4F2	8529	broad.mit.edu	37	chr19	15989675	15989675	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggtgtggtcaggcaggacgCggaagcgcagcagcgtgagc	19	10	1	1	rs143677430	byFrequency	TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr19:15989675C>T	uc002nbs.1	-	13	1519	c.1469G>A	c.(1468-1470)CGC>CAC	p.R490H	CYP4F2_uc010xot.1_Missense_Mutation_p.R341H	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	490					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						AGGCAGGACGCGGAAGCGCAG	0.672													T	15989675	T	T	15989675	3	4	15	1	0	0	0	0	1	0	0	0	4188	768	27	1	97	1	CYP4F2	19	15989675	Missense_Mutation	SNP	C	TCGA-06-0130-01A-01D-1490-08		15989675	43139308	30	1054											
ZNF578	147660	broad.mit.edu	37	chr19	53014344	53014344	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tttccaatgtaatgagactgGcgaagcctttaattgtagct	9	7	0	1			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr19:53014344G>T	uc002pzp.3	+	6	954	c.710G>T	c.(709-711)GGC>GTC	p.G237V		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	12	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		AATGAGACTGGCGAAGCCTTT	0.313													T	53014344	T	T	53014344	3	4	15	1	0	0	0	0	1	0	0	0	18007	1203	42	5	720	5	ZNF578	19	53014344	Missense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08	37024669	53014344	6114639	31	1055											
LAIR1	3903	broad.mit.edu	37	chr19	54875933	54875933	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tggatggtctgggccaggcaGagcactggaagagaagcccc	16	10	1	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr19:54875933G>A	uc002qfk.1	-	2	349	c.39C>T	c.(37-39)CTC>CTT	p.L13L	LAIR1_uc002qfl.1_Silent_p.L13L|LAIR1_uc002qfm.1_Silent_p.L13L|LAIR1_uc002qfn.1_Silent_p.L13L|LAIR1_uc010yex.1_Silent_p.L7L|LAIR1_uc002qfo.2_Intron	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like	13						integral to membrane|plasma membrane	protein binding|receptor activity			ovary(4)	4	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		GGGCCAGGCAGAGCACTGGAA	0.617													A	54875933	A	A	54875933	2	1	15	1	0	0	0	0	0	0	0	1	8602	929	33	3		3	LAIR1	19	54875933	Silent	SNP	G	TCGA-06-0130-01A-01D-1490-08	1861589	54875933	4253050	32	1056											
PTPRA	5786	broad.mit.edu	37	chr20	3003414	3003414	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atacagaacggaaggtggacGtgtatggctttgtgagccgg	16	6	0	2	rs117251752	by1000genomes	TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr20:3003414G>A	uc010zqd.1	+	15	1758	c.1441G>A	c.(1441-1443)GTG>ATG	p.V481M	PTPRA_uc002whj.2_Missense_Mutation_p.V470M|PTPRA_uc002whk.2_Missense_Mutation_p.V461M|PTPRA_uc002whl.2_Missense_Mutation_p.V461M|PTPRA_uc002whm.2_Missense_Mutation_p.V237M|PTPRA_uc002whn.2_Missense_Mutation_p.V461M|PTPRA_uc002who.2_Missense_Mutation_p.V133M	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	470	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						GAAGGTGGACGTGTATGGCTT	0.577													A	3003414	A	A	3003414	3	1	15	1	0	0	0	0	1	0	0	0	12795	1145	40	1	1458	1	PTPRA	20	3003414	Missense_Mutation	SNP	G	TCGA-06-0130-01A-01D-1490-08		3003414	60022106	33	1057											
KIF16B	55614	broad.mit.edu	37	chr20	16496298	16496298	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcacgacatctgtgccgagGgttttgaaaacctgaaagcc	10	10	2	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr20:16496298G>A	uc002wpg.1	-	4	401	c.243C>T	c.(241-243)ACC>ACT	p.T81T	KIF16B_uc010gch.1_Silent_p.T81T|KIF16B_uc010gci.1_Silent_p.T81T|KIF16B_uc010gcj.1_Silent_p.T81T	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	81	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CTGTGCCGAGGGTTTTGAAAA	0.373													A	16496298	A	A	16496298	2	1	15	1	0	0	0	0	0	0	0	1	8278	1219	43	3		3	KIF16B	20	16496298	Silent	SNP	G	TCGA-06-0130-01A-01D-1490-08	13492884	16496298	46529222	34	1058											
WFDC8	90199	broad.mit.edu	37	chr20	44181787	44181787	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atccttacctgtccaggcccTggcacaaacaaagccacacc	6	17	0	0			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr20:44181787T>C	uc002xow.2	-	5	653	c.574A>G	c.(574-576)AGG>GGG	p.R192G	WFDC8_uc002xox.2_Missense_Mutation_p.R192G	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	192	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GTCCAGGCCCTGGCACAAACA	0.502													C	44181787	C	C	44181787	3	2	15	1	0	0	0	0	1	0	0	0	17353	1579	55	4	159	4	WFDC8	20	44181787	Missense_Mutation	SNP	T	TCGA-06-0130-01A-01D-1490-08	27685489	44181787	18843733	35	1059											
TPTE	7179	broad.mit.edu	37	chr21	10951271	10951271	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aataatcaaacttacctttcTacaaatactcgaagaagaac	3	9	2	2			TCGA-06-0130-01A-01D-1490-08	TCGA-06-0130-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c09f0ebd-d604-49a3-9738-0c65fd47fbf9	86e74392-3823-43f8-b803-bf8757390521	g.chr21:10951271T>A	uc002yip.1	-	10	809	c.441A>T	c.(439-441)GTA>GTT	p.V147V	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.V129V|TPTE_uc002yir.1_Silent_p.V109V|TPTE_uc010gkv.1_Silent_p.V9V	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	147	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTACCTTTCTACAAATACTC	0.229													A	10951271	A	A	10951271	2	1	15	1	0	0	0	0	0	0	0	1	16427	1509	53	5		5	TPTE	21	10951271	Silent	SNP	T	TCGA-06-0130-01A-01D-1490-08		10951271	37178624	36	1060											
RNF207	388591	broad.mit.edu	37	chr1	6271141	6271141	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccactgctgctgctggggCcacgtcgggtggcagctgct	16	13	0	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr1:6271141C>T	uc001amg.2	+	12	1246	c.1072C>T	c.(1072-1074)CCA>TCA	p.P358S	RNF207_uc010nzp.1_RNA	NM_207396	NP_997279	Q6ZRF8	RN207_HUMAN	ring finger protein 207	358						intracellular	zinc ion binding				0	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		GCTGCTGGGGCCACGTCGGGT	0.667													T	6271141	T	T	6271141	3	4	16	1	0	0	0	0	1	0	0	0	13474	739	26	3	1114	3	RNF207	1	6271141	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08		6271141	242979480	1	1061											
CAMTA1	23261	broad.mit.edu	37	chr1	7723936	7723936	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgatggccacaagttcgcCtttcccaccacgggcagctc	9	16	1	1			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr1:7723936C>T	uc001aoi.2	+	9	1536	c.1329C>T	c.(1327-1329)GCC>GCT	p.A443A		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	443					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		ACAAGTTCGCCTTTCCCACCA	0.652													T	7723936	T	T	7723936	2	4	16	1	0	0	0	0	0	0	0	1	2613	668	24	3		3	CAMTA1	1	7723936	Silent	SNP	C	TCGA-06-0132-01A-02D-1491-08	1452795	7723936	241526685	2	1062			1	6		2	2	62	C		7.487585e-05
CAMTA1	23261	broad.mit.edu	37	chr1	7723997	7723997	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccaacgtgtccgaagagCtggtcctctccaccaccctc	7	19	1	1			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr1:7723997C>T	uc001aoi.2	+	9	1597	c.1390C>T	c.(1390-1392)CTG>TTG	p.L464L		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GTCCGAAGAGCTGGTCCTCTC	0.597													T	7723997	T	T	7723997	2	4	16	1	0	0	0	0	0	0	0	1	2613	796	28	3		3	CAMTA1	1	7723997	Silent	SNP	C	TCGA-06-0132-01A-02D-1491-08	61	7723997	241526624	3	1063			1	6		2	2	62	C		7.487585e-05
FHL3	2275	broad.mit.edu	37	chr1	38463709	38463709	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagtgagcacccttgtcggGcacaaaagaacgggagccca	13	11	0	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr1:38463709G>A	uc001ccj.2	-	4	514	c.427C>T	c.(427-429)CCC>TCC	p.P143S	FHL3_uc001cck.2_Missense_Mutation_p.P143S|FHL3_uc001ccl.2_Missense_Mutation_p.P143S|FHL3_uc001ccm.2_Missense_Mutation_p.P35S|FHL3_uc009vvl.1_Missense_Mutation_p.P143S	NM_004468	NP_004459	Q13643	FHL3_HUMAN	four and a half LIM domains 3	143	LIM zinc-binding 2.				muscle organ development		zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CCCTTGTCGGGCACAAAAGAA	0.622													A	38463709	A	A	38463709	3	1	16	1	0	0	0	0	1	0	0	0	5880	1203	42	3	427	3	FHL3	1	38463709	Missense_Mutation	SNP	G	TCGA-06-0132-01A-02D-1491-08	30739712	38463709	210786912	4	1064											
PSMA5	5686	broad.mit.edu	37	chr1	109964523	109964523	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccacttgaaataatcttcCttcgggagaaaaagtattca	6	8	2	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr1:109964523C>T	uc001dxn.2	-	2	140	c.55G>A	c.(55-57)GGA>AGA	p.G19R	PSMA5_uc010ovj.1_Intron	NM_002790	NP_002781	P28066	PSA5_HUMAN	proteasome alpha 5 subunit	19					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity				0		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.045)|Colorectal(144;0.116)|Epithelial(280;0.187)|all cancers(265;0.196)|LUSC - Lung squamous cell carcinoma(189;0.235)		AATAATCTTCCTTCGGGAGAA	0.348													T	109964523	T	T	109964523	3	4	16	1	0	0	0	0	1	0	0	0	12670	690	24	3	702	3	PSMA5	1	109964523	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08	71500814	109964523	139286098	5	1065											
SPAG17	200162	broad.mit.edu	37	chr1	118640437	118640437	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagaaagttttaagctctttTatggcattttctttcttcaa	5	7	4	1			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr1:118640437T>C	uc001ehk.2	-	7	935	c.867A>G	c.(865-867)ATA>ATG	p.I289M		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	289	Potential.					cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TAAGCTCTTTTATGGCATTTT	0.333													C	118640437	C	C	118640437	3	2	16	1	0	0	0	0	1	0	0	0	14979	1744	61	4	5972	4	SPAG17	1	118640437	Missense_Mutation	SNP	T	TCGA-06-0132-01A-02D-1491-08	8675914	118640437	130610184	6	1066											
NBPF10	100132406	broad.mit.edu	37	chr1	145325997	145325997	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaagggcctgaagtcttgcaAgactcactggatagatgtta	11	7	2	3			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr1:145325997A>G	uc001end.3	+	32	4130	c.4095A>G	c.(4093-4095)CAA>CAG	p.Q1365Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oym.1_Intron|NBPF10_uc010oyn.1_Intron|NBPF10_uc010oyo.1_Intron|NBPF10_uc010oyp.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	1290											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AAGTCTTGCAAGACTCACTGG	0.468													G	145325997	G	G	145325997	2	3	16	1	0	0	0	0	0	0	0	1	10193	69	3	4		4	NBPF10	1	145325997	Silent	SNP	A	TCGA-06-0132-01A-02D-1491-08	26685560	145325997	103924624	7	1067											
FCRLA	84824	broad.mit.edu	37	chr1	161682911	161682911	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcacctcccacattgaatcCagctcctcagaaatcagctg	6	15	2	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr1:161682911C>T	uc001gbe.2	+	6	1132	c.890C>T	c.(889-891)CCA>CTA	p.P297L	FCRLA_uc001gbd.2_Missense_Mutation_p.P291L|FCRLA_uc001gbf.2_Missense_Mutation_p.P202L|FCRLA_uc001gbg.2_Missense_Mutation_p.P151L|FCRLA_uc009wuo.2_Missense_Mutation_p.P157L|FCRLA_uc009wup.2_Missense_Mutation_p.P107L|FCRLA_uc009wuq.2_Missense_Mutation_p.P56L	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	274	Pro-rich.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			ACATTGAATCCAGCTCCTCAG	0.582													T	161682911	T	T	161682911	3	4	16	1	0	0	0	0	1	0	0	0	5800	594	21	3	912	3	FCRLA	1	161682911	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08	16356914	161682911	87567710	8	1068											
CACNA1S	779	broad.mit.edu	37	chr1	201012596	201012596	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtctctgattggccatgaCggggggcagggagttggtcc	19	8	1	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr1:201012596C>T	uc001gvv.2	-	40	5088	c.4861G>A	c.(4861-4863)GTC>ATC	p.V1621I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1621	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTGGCCATGACGGGGGGCAGG	0.567											OREG0014067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	201012596	T	T	201012596	3	4	16	1	0	0	0	0	1	0	0	0	2547	536	19	1	780	1	CACNA1S	1	201012596	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08	39329685	201012596	48238025	9	1069											
YIPF4	84272	broad.mit.edu	37	chr2	32530586	32530586	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgttttgggctgcctacaGtgctgcttcattgttagtgg	13	7	1	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr2:32530586G>A	uc002rok.2	+	6	893	c.626G>A	c.(625-627)AGT>AAT	p.S209N		NM_032312	NP_115688	Q9BSR8	YIPF4_HUMAN	Yip1 domain family, member 4	209	Helical; (Potential).					endoplasmic reticulum|integral to membrane	protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GCTGCCTACAGTGCTGCTTCA	0.323													A	32530586	A	A	32530586	3	1	16	1	0	0	0	0	1	0	0	0	17477	1029	36	3	648	3	YIPF4	2	32530586	Missense_Mutation	SNP	G	TCGA-06-0132-01A-02D-1491-08		32530586	210668787	10	1070											
RAB11FIP5	26056	broad.mit.edu	37	chr2	73315741	73315741	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctcccattgacacagagCgaagagcgggaggcagcatc	14	11	0	3			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr2:73315741C>T	uc002siu.3	-	3	1246	c.1005G>A	c.(1003-1005)TCG>TCA	p.S335S	RAB11FIP5_uc002sit.3_Silent_p.S257S	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	335					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						TGACACAGAGCGAAGAGCGGG	0.622													T	73315741	T	T	73315741	2	4	16	1	0	0	0	0	0	0	0	1	12897	755	27	1		1	RAB11FIP5	2	73315741	Silent	SNP	C	TCGA-06-0132-01A-02D-1491-08	40785155	73315741	169883632	11	1071											
LCT	3938	broad.mit.edu	37	chr2	136566075	136566075	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcagtatcctccgtgttcGgattggtcagccccactccg	9	14	2	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr2:136566075G>A	uc002tuu.1	-	8	3853	c.3842C>T	c.(3841-3843)CCG>CTG	p.P1281L		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1281	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTCCGTGTTCGGATTGGTCAG	0.493													A	136566075	A	A	136566075	3	1	16	1	0	0	0	0	1	0	0	0	8693	1116	39	2	1981	2	LCT	2	136566075	Missense_Mutation	SNP	G	TCGA-06-0132-01A-02D-1491-08	63250334	136566075	106633298	12	1072											
MBD5	55777	broad.mit.edu	37	chr2	149248058	149248058	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaggacgttcaatgttggCgacttggtctggggccaaat	13	9	2	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr2:149248058C>T	uc002twm.3	+	12	5146	c.4158C>T	c.(4156-4158)GGC>GGT	p.G1386G	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Silent_p.G1386G|MBD5_uc002two.2_Silent_p.G644G|MBD5_uc002twp.2_Silent_p.G436G	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1386	PWWP.					chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TCAATGTTGGCGACTTGGTCT	0.448													T	149248058	T	T	149248058	2	4	16	1	0	0	0	0	0	0	0	1	9347	755	27	1		1	MBD5	2	149248058	Silent	SNP	C	TCGA-06-0132-01A-02D-1491-08	12681983	149248058	93951315	13	1073											
SCN3A	6328	broad.mit.edu	37	chr2	166019113	166019113	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	taaatgtgctcattgttacaTtaacaaatgtcccatttgaa	5	7	1	1			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr2:166019113T>A	uc002ucx.2	-	8	1412	c.920A>T	c.(919-921)AAT>ATT	p.N307I	SCN3A_uc002ucy.2_Missense_Mutation_p.N307I|SCN3A_uc002ucz.2_Missense_Mutation_p.N307I|SCN3A_uc002uda.1_Missense_Mutation_p.N176I|SCN3A_uc002udb.1_Missense_Mutation_p.N176I	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	307						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CATTGTTACATTAACAAATGT	0.363													A	166019113	A	A	166019113	3	1	16	1	0	0	0	0	1	0	0	0	13918	1493	52	5	5166	5	SCN3A	2	166019113	Missense_Mutation	SNP	T	TCGA-06-0132-01A-02D-1491-08	16771055	166019113	77180260	14	1074											
SCN9A	6335	broad.mit.edu	37	chr2	167055670	167055670	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	accactaaccatgggcagatCcatggcaatgagctggactt	10	11	0	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr2:167055670C>A	uc010fpl.2	-	27	5787	c.5446G>T	c.(5446-5448)GAT>TAT	p.D1816Y	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1827						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ATGGGCAGATCCATGGCAATG	0.463													A	167055670	A	A	167055670	3	1	16	1	0	0	0	0	1	0	0	0	13925	855	30	5	491	5	SCN9A	2	167055670	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08	1036557	167055670	76143703	15	1075											
ZSWIM2	151112	broad.mit.edu	37	chr2	187693302	187693302	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgctaggtaaaattccaagTctattttgttttaagactaa	6	5	1	1			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr2:187693302T>C	uc002upu.1	-	9	1351	c.1311A>G	c.(1309-1311)AGA>AGG	p.R437R		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	437					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			AAATTCCAAGTCTATTTTGTT	0.328													C	187693302	C	C	187693302	2	2	16	1	0	0	0	0	0	0	0	1	18238	1664	58	4		4	ZSWIM2	2	187693302	Silent	SNP	T	TCGA-06-0132-01A-02D-1491-08	20637632	187693302	55506071	16	1076											
ANO7	50636	broad.mit.edu	37	chr2	242151595	242151595	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaacttctactcctcacccGtctacattgccttcttcaag	3	16	6	0	rs111600763	byFrequency	TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr2:242151595G>A	uc002wax.2	+	16	1913	c.1810G>A	c.(1810-1812)GTC>ATC	p.V604I		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	604	Helical; (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CTCCTCACCCGTCTACATTGC	0.562													A	242151595	A	A	242151595	3	1	16	1	0	0	0	0	1	0	0	0	702	1145	40	1	1944	1	ANO7	2	242151595	Missense_Mutation	SNP	G	TCGA-06-0132-01A-02D-1491-08	54458293	242151595	1047778	17	1077											
CHL1	10752	broad.mit.edu	37	chr3	383663	383663	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagatctatacttcgcaaacGtggaagaaaaggacagtcgc	11	8	1	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr3:383663G>A	uc003bou.2	+	7	848	c.577G>A	c.(577-579)GTG>ATG	p.V193M	CHL1_uc003bot.2_Missense_Mutation_p.V193M|CHL1_uc003bow.1_Missense_Mutation_p.V193M|CHL1_uc011asi.1_Missense_Mutation_p.V193M	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	193	Ig-like C2-type 2.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CTTCGCAAACGTGGAAGAAAA	0.383													A	383663	A	A	383663	3	1	16	1	0	0	0	0	1	0	0	0	3349	1145	40	1	595	1	CHL1	3	383663	Missense_Mutation	SNP	G	TCGA-06-0132-01A-02D-1491-08		383663	197638767	18	1078											
ZBTB20	26137	broad.mit.edu	37	chr3	114069362	114069362	+	Frame_Shift_Del	DEL	G	-	-													aggctgaagaggaaaggcttGgggccactgcccgcgggctg							TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr3:114069362delG	uc003ebi.2	-	4	1743	c.1563delC	c.(1561-1563)CCCfs	p.P521fs	ZBTB20_uc003ebj.2_Frame_Shift_Del_p.P448fs|ZBTB20_uc010hqp.2_Frame_Shift_Del_p.P448fs|ZBTB20_uc003ebk.2_Frame_Shift_Del_p.P448fs|ZBTB20_uc003ebl.2_Frame_Shift_Del_p.P448fs|ZBTB20_uc003ebm.2_Frame_Shift_Del_p.P448fs|ZBTB20_uc003ebn.2_Frame_Shift_Del_p.P448fs|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GGAAAGGCTTGGGGCCACTGC	0.627													-	114069362	-	-	114069362	7	5	16	1	0	1	0	1	0	0	0	0	17526	1335	47	0	670	0	ZBTB20	3	114069362	Frame_Shift_Del	DEL	G	TCGA-06-0132-01A-02D-1491-08	113685699	114069362	83953068	19	1079											
SPOCK3	50859	broad.mit.edu	37	chr4	167656159	167656159	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atttcatcttcatcattcatAatatcgtcttcatcatcctc	1	12	8	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr4:167656159A>G	uc003iri.1	-	12	1365	c.1224T>C	c.(1222-1224)ATT>ATC	p.I408I	SPOCK3_uc011cjp.1_Silent_p.I365I|SPOCK3_uc011cjq.1_Silent_p.I417I|SPOCK3_uc011cjr.1_Silent_p.I288I|SPOCK3_uc003irj.1_Silent_p.I405I|SPOCK3_uc011cjs.1_Silent_p.I357I|SPOCK3_uc011cjt.1_Silent_p.I316I|SPOCK3_uc011cju.1_Silent_p.I301I|SPOCK3_uc011cjv.1_Silent_p.I310I	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	408	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		catcattcataatatcgtctt	0.07													G	167656159	G	G	167656159	2	3	16	1	0	0	0	0	0	0	0	1	15080	358	13	4		4	SPOCK3	4	167656159	Silent	SNP	A	TCGA-06-0132-01A-02D-1491-08		167656159	23498117	20	1080											
FSTL4	23105	broad.mit.edu	37	chr5	132556518	132556518	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatggatgacgatgataccGtcgtcggagaagacatagaa	14	6	0	5	rs141735817	byFrequency	TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr5:132556518G>A	uc003kyn.1	-	12	1598	c.1380C>T	c.(1378-1380)GAC>GAT	p.D460D	FSTL4_uc003kym.1_Silent_p.D109D	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	460						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CGATGATACCGTCGTCGGAGA	0.547													A	132556518	A	A	132556518	2	1	16	1	0	0	0	0	0	0	0	1	6079	1136	40	1		1	FSTL4	5	132556518	Silent	SNP	G	TCGA-06-0132-01A-02D-1491-08		132556518	48358742	21	1081											
PCDHA9	9752	broad.mit.edu	37	chr5	140229589	140229589	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggcggttgggcgagcgctcGctgtcgagctacgtgtcagt	17	11	1	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr5:140229589G>A	uc003lhu.2	+	1	2233	c.1509G>A	c.(1507-1509)TCG>TCA	p.S503S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.S503S	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGCGCTCGCTGTCGAGCT	0.672													A	140229589	A	A	140229589	2	1	16	1	0	0	0	0	0	0	0	1	11531	1074	38	1		1	PCDHA9	5	140229589	Silent	SNP	G	TCGA-06-0132-01A-02D-1491-08	7673071	140229589	40685671	22	1082											
LAMB1	3912	broad.mit.edu	37	chr7	107591684	107591684	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactcacctcggcactccacGtcggggtctccccagaagag	10	16	2	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr7:107591684G>A	uc003vew.2	-	24	3713	c.3378C>T	c.(3376-3378)GAC>GAT	p.D1126D	LAMB1_uc003vev.2_Silent_p.D1150D	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1126	Laminin EGF-like 12.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCACTCCACGTCGGGGTCTC	0.572													A	107591684	A	A	107591684	2	1	16	1	0	0	0	0	0	0	0	1	8610	1136	40	1		1	LAMB1	7	107591684	Silent	SNP	G	TCGA-06-0132-01A-02D-1491-08		107591684	51546979	23	1083											
SGK223	157285	broad.mit.edu	37	chr8	8175745	8175745	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagacgccaggtactggcaGcaaagccagtcctccagctc	11	15	0	1			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr8:8175745G>A	uc003wsh.3	-	5	4140	c.4140C>T	c.(4138-4140)TGC>TGT	p.C1380C		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1380							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGTACTGGCAGCAAAGCCAGT	0.642													A	8175745	A	A	8175745	2	1	16	1	0	0	0	0	0	0	0	1	14210	963	34	3		3	SGK223	8	8175745	Silent	SNP	G	TCGA-06-0132-01A-02D-1491-08		8175745	138188277	24	1084											
PIP5K1B	8395	broad.mit.edu	37	chr9	71555697	71555697	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacgacaggcctacactctAttcaaacaggtaatacttag	6	11	2	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr9:71555697A>C	uc004agu.2	+	14	1798	c.1493A>C	c.(1492-1494)TAT>TCT	p.Y498S	PIP5K1B_uc011lrq.1_Missense_Mutation_p.Y498S|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	498						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		CCTACACTCTATTCAAACAGG	0.443													C	71555697	C	C	71555697	3	2	16	1	0	0	0	0	1	0	0	0	11940	449	16	5	1535	5	PIP5K1B	9	71555697	Missense_Mutation	SNP	A	TCGA-06-0132-01A-02D-1491-08		71555697	69657734	25	1085											
SUSD1	64420	broad.mit.edu	37	chr9	114840947	114840947	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcggctgctgctactgatatTaaaggtcatttcctgggcaa	10	9	1	1			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr9:114840947T>C	uc004bfu.2	-	12	1665	c.1624A>G	c.(1624-1626)AAT>GAT	p.N542D	SUSD1_uc010mui.2_Missense_Mutation_p.N542D|SUSD1_uc010muj.2_Missense_Mutation_p.N542D	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	542	Extracellular (Potential).					integral to membrane	calcium ion binding				0						CTACTGATATTAAAGGTCATT	0.488													C	114840947	C	C	114840947	3	2	16	1	0	0	0	0	1	0	0	0	15404	1754	61	4	643	4	SUSD1	9	114840947	Missense_Mutation	SNP	T	TCGA-06-0132-01A-02D-1491-08	43285250	114840947	26372484	26	1086											
ABCG4	64137	broad.mit.edu	37	chr11	119031668	119031668	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtttagaggaacgctgccCgttccgggagccacagagca	13	11	0	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr11:119031668C>T	uc001pvs.2	+	15	2129	c.1793C>T	c.(1792-1794)CCG>CTG	p.P598L	ABCG4_uc009zar.2_Missense_Mutation_p.P598L	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	598	Extracellular (Potential).|ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GAACGCTGCCCGTTCCGGGAG	0.567													T	119031668	T	T	119031668	3	4	16	1	0	0	0	0	1	0	0	0	70	652	23	2	1847	2	ABCG4	11	119031668	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08		119031668	15974848	27	1087											
TSPAN9	10867	broad.mit.edu	37	chr12	3387673	3387673	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcccccagcttcccttcGttgtctgcagccaacctggt	7	17	2	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr12:3387673G>A	uc001qlp.2	+	4	297	c.150G>A	c.(148-150)TCG>TCA	p.S50S		NM_006675	NP_006666	O75954	TSN9_HUMAN	tetraspanin 9	50	Extracellular (Potential).					integral to plasma membrane|membrane fraction				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			GCTTCCCTTCGTTGTCTGCAG	0.597													A	3387673	A	A	3387673	2	1	16	1	0	0	0	0	0	0	0	1	16651	1132	40	1		1	TSPAN9	12	3387673	Silent	SNP	G	TCGA-06-0132-01A-02D-1491-08		3387673	130464222	28	1088											
OR9K2	441639	broad.mit.edu	37	chr12	55524385	55524385	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agttgtgagtgtgctgtatgGtgctgtcttttttatgtatc	12	4	1	1			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr12:55524385G>A	uc010spe.1	+	1	833	c.833G>A	c.(832-834)GGT>GAT	p.G278D		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	278	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						GTGCTGTATGGTGCTGTCTTT	0.443													A	55524385	A	A	55524385	3	1	16	1	0	0	0	0	1	0	0	0	11254	1261	44	3	835	3	OR9K2	12	55524385	Missense_Mutation	SNP	G	TCGA-06-0132-01A-02D-1491-08	52136712	55524385	78327510	29	1089											
APOF	319	broad.mit.edu	37	chr12	56755194	56755194	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccggctgagagatgtttgCgtctttctgatcttggtaat	11	8	3	3			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr12:56755194C>T	uc001sle.1	-	2	850	c.796G>A	c.(796-798)GCA>ACA	p.A266T		NM_001638	NP_001629	Q13790	APOF_HUMAN	apolipoprotein F precursor	266					cholesterol metabolic process	high-density lipoprotein particle|low-density lipoprotein particle	cholesterol binding|lipid transporter activity|receptor binding				0						GAGATGTTTGCGTCTTTCTGA	0.493													T	56755194	T	T	56755194	3	4	16	1	0	0	0	0	1	0	0	0	803	768	27	1	188	1	APOF	12	56755194	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08	1230809	56755194	77096701	30	1090											
FOXN4	121643	broad.mit.edu	37	chr12	109719238	109719238	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcgaagtccatgatgctcGggtcgagggcatccacctca	13	12	1	1			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr12:109719238G>A	uc001toe.3	-	9	1373	c.1268C>T	c.(1267-1269)CCG>CTG	p.P423L	FOXN4_uc009zvg.2_Missense_Mutation_p.P220L|FOXN4_uc001tof.3_Missense_Mutation_p.P243L	NM_213596	NP_998761	Q96NZ1	FOXN4_HUMAN	forkhead box N4	423					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|lung(1)	2						CATGATGCTCGGGTCGAGGGC	0.627													A	109719238	A	A	109719238	3	1	16	1	0	0	0	0	1	0	0	0	6022	1116	39	2	293	2	FOXN4	12	109719238	Missense_Mutation	SNP	G	TCGA-06-0132-01A-02D-1491-08	52964044	109719238	24132657	31	1091											
SERPINA12	145264	broad.mit.edu	37	chr14	94953819	94953819	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcatccatcttcagctcagCcttgtgcacagcctacggaa	7	15	4	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr14:94953819C>T	uc001ydj.2	-	6	1862	c.1066G>A	c.(1066-1068)GCT>ACT	p.A356T		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	356					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		TTCAGCTCAGCCTTGTGCACA	0.597													T	94953819	T	T	94953819	3	4	16	1	0	0	0	0	1	0	0	0	14089	739	26	3	182	3	SERPINA12	14	94953819	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08		94953819	12395721	32	1092											
PEPD	5184	broad.mit.edu	37	chr19	33892682	33892682	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcagcactgcctcatagacGgccttctggtctgcagtgaa	11	13	3	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr19:33892682G>A	uc002nur.3	-	12	1047	c.912C>T	c.(910-912)GCC>GCT	p.A304A	PEPD_uc010xrr.1_Silent_p.A263A|PEPD_uc010xrs.1_Silent_p.A240A	NM_000285	NP_000276	P12955	PEPD_HUMAN	prolidase isoform 1	304					cellular amino acid metabolic process|collagen catabolic process|proteolysis		aminopeptidase activity|dipeptidase activity|manganese ion binding|metallocarboxypeptidase activity			ovary(2)	2	Esophageal squamous(110;0.137)					CCTCATAGACGGCCTTCTGGT	0.627													A	33892682	A	A	33892682	2	1	16	1	0	0	0	0	0	0	0	1	11728	1103	39	2		2	PEPD	19	33892682	Silent	SNP	G	TCGA-06-0132-01A-02D-1491-08		33892682	25236301	33	1093											
NLRP12	91662	broad.mit.edu	37	chr19	54313742	54313742	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaggctcgttgtccctcaCgtaattgaagacttggcccg	12	11	1	3			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr19:54313742C>T	uc002qch.3	-	3	1391	c.1171G>A	c.(1171-1173)GTG>ATG	p.V391M	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.V391M|NLRP12_uc002qcj.3_Missense_Mutation_p.V391M|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.V391M	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	391	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TTGTCCCTCACGTAATTGAAG	0.562													T	54313742	T	T	54313742	3	4	16	1	0	0	0	0	1	0	0	0	10474	536	19	1	2142	1	NLRP12	19	54313742	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08	20421060	54313742	4815241	34	1094											
SLC5A4	6527	broad.mit.edu	37	chr22	32627012	32627012	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gtagttggtgcagccaacatCaacgccacagtgtttcacgc	10	12	2	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chr22:32627012C>G	uc003ami.2	-	10	1074	c.1072G>C	c.(1072-1074)GAT>CAT	p.D358H		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	358	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CAGCCAACATCAACGCCACAG	0.522													G	32627012	G	G	32627012	3	3	16	1	0	0	0	0	1	0	0	0	14667	826	29	5	931	5	SLC5A4	22	32627012	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08		32627012	18677554	35	1095											
CXorf59	286464	broad.mit.edu	37	chrX	36103467	36103467	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caattctactcatcaacctcGccaccccaaaagttttccag	3	16	3	0			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chrX:36103467G>A	uc004ddk.1	+	5	639	c.453G>A	c.(451-453)TCG>TCA	p.S151S		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	151						integral to membrane				central_nervous_system(1)	1						CATCAACCTCGCCACCCCAAA	0.333													A	36103467	A	A	36103467	2	1	16	1	0	0	0	0	0	0	0	1	4115	1074	38	1		1	CXorf59	23	36103467	Silent	SNP	G	TCGA-06-0132-01A-02D-1491-08		36103467	119167093	36	1096											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299499	125299499	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcccggcctccttgtcccGcatgagggggatgcgcgtga	15	14	0	2			TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chrX:125299499G>A	uc004euk.1	-	1	436	c.409C>T	c.(409-411)CGG>TGG	p.R137W		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	137										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						TCCTTGTCCCGCATGAGGGGG	0.642													A	125299499	A	A	125299499	3	1	16	1	0	0	0	0	1	0	0	0	4265	1086	38	1	986	1	DCAF12L2	23	125299499	Missense_Mutation	SNP	G	TCGA-06-0132-01A-02D-1491-08	89196032	125299499	29971061	37	1097											
OR13H1	347468	broad.mit.edu	37	chrX	130678349	130678349	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccccgatgtttggctcaaaCgagtgtctccttggctttgg	11	11	2	0	rs149527425	byFrequency	TCGA-06-0132-01A-02D-1491-08	TCGA-06-0132-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	53c2e159-5774-499f-b0d1-e04fa3faf5c3	740f8d17-3563-4a13-8089-509a5989c33d	g.chrX:130678349C>T	uc011muw.1	+	1	302	c.302C>T	c.(301-303)ACG>ATG	p.T101M	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	101	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					TTGGCTCAAACGAGTGTCTCC	0.517													T	130678349	T	T	130678349	3	4	16	1	0	0	0	0	1	0	0	0	10943	536	19	1	304	1	OR13H1	23	130678349	Missense_Mutation	SNP	C	TCGA-06-0132-01A-02D-1491-08	5378850	130678349	24592211	38	1098											
RPS6KA1	6195	broad.mit.edu	37	chr1	26885365	26885365	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcttcagcttcgtggccacCggcctgatggaagacgacgg	15	12	1	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:26885365C>T	uc001bmr.1	+	14	1315	c.1152C>T	c.(1150-1152)ACC>ACT	p.T384T	RPS6KA1_uc010ofe.1_Silent_p.T292T|RPS6KA1_uc010off.1_Silent_p.T368T|RPS6KA1_uc001bms.1_Silent_p.T393T|RPS6KA1_uc009vsl.1_Silent_p.T227T	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	384	AGC-kinase C-terminal.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		TCGTGGCCACCGGCCTGATGG	0.647													T	26885365	T	T	26885365	2	4	17	1	0	0	0	0	0	0	0	1	13650	639	23	2		2	RPS6KA1	1	26885365	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08		26885365	222365256	1	1099											
MACF1	23499	broad.mit.edu	37	chr1	39549978	39549978	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgatcttacaggagcgagCggtcggggagcctgtctccc	15	12	2	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:39549978C>T	uc010ois.1	+	3	293	c.88C>T	c.(88-90)CGG>TGG	p.R30W	MACF1_uc010oir.1_Silent_p.S25S	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	30	Actin-binding.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGGAGCGAGCGGTCGGGGAG	0.612													T	39549978	T	T	39549978	3	4	17	1	0	0	0	0	1	0	0	0	9144	759	27	1	90	1	MACF1	1	39549978	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	12664613	39549978	209700643	2	1100											
C1orf161	126868	broad.mit.edu	37	chr1	116666899	116666899	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagacagatgtgaacatcgaCggagacattgtgcctgccaa	12	9	0	4			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:116666899C>T	uc001egc.1	+	4	667	c.402C>T	c.(400-402)GAC>GAT	p.D134D		NM_152367	NP_689580	Q8N8X9	MB213_HUMAN	hypothetical protein LOC126868	134											0	Lung SC(450;0.184)	all_cancers(81;0.00142)|all_lung(203;0.000139)|all_epithelial(167;0.000401)|Lung NSC(69;0.000705)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TGAACATCGACGGAGACATTG	0.552													T	116666899	T	T	116666899	2	4	17	1	0	0	0	0	0	0	0	1	2009	535	19	1		1	C1orf161	1	116666899	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	77116921	116666899	132583722	3	1101											
PDE4DIP	9659	broad.mit.edu	37	chr1	144873981	144873981	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cctgagatgcactggttgatGatggtttagaagacaacaca	11	7	0	5			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:144873981G>T	uc001elw.3	-	31	5267	c.4976C>A	c.(4975-4977)TCA>TAA	p.S1659*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Nonsense_Mutation_p.S1615*|PDE4DIP_uc001elv.3_Nonsense_Mutation_p.S666*	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1659					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ACTGGTTGATGATGGTTTAGA	0.473			T	PDGFRB	MPD								T	144873981	T	T	144873981	4	4	17	1	0	0	0	0	0	1	0	0	11643	1294	45	5	2120	5	PDE4DIP	1	144873981	Nonsense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	28207082	144873981	104376640	4	1102											
MTMR11	10903	broad.mit.edu	37	chr1	149901596	149901596	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tacccaggcagcagcagcccTggaggtaaagggcaagctcc	13	13	0	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:149901596T>C	uc001etl.3	-	16	2111	c.1860A>G	c.(1858-1860)CCA>CCG	p.P620P	SF3B4_uc001etj.1_5'Flank|SF3B4_uc001etk.1_5'Flank|SF3B4_uc009wll.1_5'Flank|MTMR11_uc001etm.1_Silent_p.P548P	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	620	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GCAGCAGCCCTGGAGGTAAAG	0.587													C	149901596	C	C	149901596	2	2	17	1	0	0	0	0	0	0	0	1	9940	1567	55	4		4	MTMR11	1	149901596	Silent	SNP	T	TCGA-06-0137-01A-01D-1490-08	5027615	149901596	99349025	5	1103											
NTRK1	4914	broad.mit.edu	37	chr1	156836717	156836717	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcaggaatctctccttcaaCgctctggagtctctctcctg	8	15	5	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:156836717C>T	uc001fqh.1	+	4	431	c.375C>T	c.(373-375)AAC>AAT	p.N125N	NTRK1_uc001fqf.1_Silent_p.N95N|NTRK1_uc009wsi.1_Translation_Start_Site|NTRK1_uc001fqi.1_Silent_p.N125N|NTRK1_uc009wsk.1_Silent_p.N125N	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	125	LRR 2.|Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TCTCCTTCAACGCTCTGGAGT	0.587			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			T	156836717	T	T	156836717	2	4	17	1	0	0	0	0	0	0	0	1	10706	535	19	1		1	NTRK1	1	156836717	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	6935121	156836717	92413904	6	1104											
FCRL2	79368	broad.mit.edu	37	chr1	157739709	157739709	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctgatcctgtgagtcaccGtttctgccttgcaccagtaa	8	12	3	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:157739709G>A	uc001fre.2	-	4	601	c.542C>T	c.(541-543)ACG>ATG	p.T181M	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.T181M|FCRL2_uc009wsp.2_Intron|FCRL2_uc010pia.1_Missense_Mutation_p.T181M	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	181	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GTGAGTCACCGTTTCTGCCTT	0.527													A	157739709	A	A	157739709	3	1	17	1	0	0	0	0	1	0	0	0	5795	1145	40	1	1020	1	FCRL2	1	157739709	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	902992	157739709	91510912	7	1105											
FCAMR	83953	broad.mit.edu	37	chr1	207135779	207135779	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccatcttgggggccccagaCggcaccagtacttcctctgg	11	15	2	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:207135779C>T	uc001hfa.3	-	5	931	c.431G>A	c.(430-432)CGT>CAT	p.R144H	FCAMR_uc001hfb.2_Missense_Mutation_p.R144H|FCAMR_uc009xca.1_Missense_Mutation_p.R144H|FCAMR_uc001hfc.2_Missense_Mutation_p.R119H	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	99	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						GGGCCCCAGACGGCACCAGTA	0.582													T	207135779	T	T	207135779	3	4	17	1	0	0	0	0	1	0	0	0	5772	536	19	1	1318	1	FCAMR	1	207135779	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	49396070	207135779	42114842	8	1106											
PCNXL2	80003	broad.mit.edu	37	chr1	233231513	233231513	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaggatacgaggaatggcaaAgagctgagcaaacacgtgaa	13	6	0	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:233231513A>G	uc001hvl.2	-	22	4169	c.3934T>C	c.(3934-3936)TTT>CTT	p.F1312L	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_Intron|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1312	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GGAATGGCAAAGAGCTGAGCA	0.473													G	233231513	G	G	233231513	3	3	17	1	0	0	0	0	1	0	0	0	11592	72	3	4	2531	4	PCNXL2	1	233231513	Missense_Mutation	SNP	A	TCGA-06-0137-01A-01D-1490-08	26095734	233231513	16019108	9	1107											
C1orf100	200159	broad.mit.edu	37	chr1	244528021	244528021	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatgactgccatccgactaCgagaatttattgagcgtcgc	9	11	1	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:244528021C>T	uc001iah.2	+	2	132	c.19C>T	c.(19-21)CGA>TGA	p.R7*	C1orf100_uc001iai.2_Nonsense_Mutation_p.R7*	NM_001012970	NP_001012988	Q5SVJ3	CA100_HUMAN	hypothetical protein LOC200159	7											0	all_cancers(71;3.94e-05)|all_epithelial(71;0.000138)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|all_lung(81;0.0736)|Ovarian(71;0.0761)|Lung NSC(105;0.103)		all cancers(7;8.19e-08)|GBM - Glioblastoma multiforme(7;2.05e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.000984)			CATCCGACTACGAGAATTTAT	0.468													T	244528021	T	T	244528021	4	4	17	1	0	0	0	0	0	1	0	0	1975	528	19	1	21	1	C1orf100	1	244528021	Nonsense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	11296508	244528021	4722600	10	1108											
OR2T10	127069	broad.mit.edu	37	chr1	248756435	248756435	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtaagacactgaaatgaccGtcacaggtatcaggagcatg	11	8	2	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr1:248756435G>A	uc010pzn.1	-	1	635	c.635C>T	c.(634-636)ACG>ATG	p.T212M		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGAAATGACCGTCACAGGTAT	0.458													A	248756435	A	A	248756435	3	1	17	1	0	0	0	0	1	0	0	0	11017	1145	40	1	306	1	OR2T10	1	248756435	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	4228414	248756435	494186	11	1109											
ABCG8	64241	broad.mit.edu	37	chr2	44078770	44078770	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatcactggccgaggtcacGgcggcaagatcaagtcaggc	14	11	4	2	rs143276716		TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr2:44078770G>A	uc002rtq.2	+	4	460	c.370G>A	c.(370-372)GGC>AGC	p.G124S	ABCG8_uc010yoa.1_Missense_Mutation_p.G124S	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	124	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CCGAGGTCACGGCGGCAAGAT	0.617													A	44078770	A	A	44078770	3	1	17	1	0	0	0	0	1	0	0	0	72	1116	39	2	384	2	ABCG8	2	44078770	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08		44078770	199120603	12	1110											
CFC1B	653275	broad.mit.edu	37	chr2	131356244	131356244	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcccgggagtaggggagcGgctcctccggcccccagccc	15	17	0	0	rs139623987		TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr2:131356244G>A	uc002tro.1	-	3	609	c.218C>T	c.(217-219)CCG>CTG	p.P73L		NM_001079530	NP_001072998	P0CG36	CFC1B_HUMAN	cripto, FRL-1, cryptic family 1B	73					gastrulation	extracellular region					0	Colorectal(110;0.1)					GTAGGGGAGCGGCTCCTCCGG	0.622													A	131356244	A	A	131356244	3	1	17	1	0	0	0	0	1	0	0	0	3280	1116	39	2	1165	2	CFC1B	2	131356244	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	87277474	131356244	111843129	13	1111											
TTN	7273	broad.mit.edu	37	chr2	179497473	179497473	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aacttagcctcatctttctcGaagactttaacatcactgag	5	11	4	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr2:179497473G>A	uc010zfg.1	-	184	35780	c.35556C>T	c.(35554-35556)TTC>TTT	p.F11852F	TTN_uc010zfh.1_Silent_p.F5547F|TTN_uc010zfi.1_Silent_p.F5480F|TTN_uc010zfj.1_Silent_p.F5355F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12779							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCTTTCTCGAAGACTTTAA	0.428													A	179497473	A	A	179497473	2	1	17	1	0	0	0	0	0	0	0	1	16732	1049	37	2		2	TTN	2	179497473	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	48141229	179497473	63701900	14	1112											
ITGA4	3676	broad.mit.edu	37	chr2	182358131	182358131	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccgtgcagatgggatctcGtcaaccttctcacaggtaag	12	11	3	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr2:182358131G>A	uc002unu.2	+	11	1996	c.1233G>A	c.(1231-1233)TCG>TCA	p.S411S		NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	411	FG-GAP 6.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATGGGATCTCGTCAACCTTCT	0.368													A	182358131	A	A	182358131	2	1	17	1	0	0	0	0	0	0	0	1	7878	1132	40	1		1	ITGA4	2	182358131	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	2860658	182358131	60841242	15	1113											
SERPINE2	5270	broad.mit.edu	37	chr2	224866465	224866465	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atcccatggggagagatcacGatgttgtcatgaggcctcga	13	9	2	2	rs3795875		TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr2:224866465G>A	uc002vnu.2	-	2	396	c.153C>T	c.(151-153)ATC>ATT	p.I51I	SERPINE2_uc002vnt.2_Silent_p.I51I|SERPINE2_uc010zlr.1_Silent_p.I63I|SERPINE2_uc002vnv.2_Silent_p.I51I	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	51					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		GAGAGATCACGATGTTGTCAT	0.567													A	224866465	A	A	224866465	2	1	17	1	0	0	0	0	0	0	0	1	14112	1048	37	2		2	SERPINE2	2	224866465	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	42508334	224866465	18332908	16	1114											
B3GNT7	93010	broad.mit.edu	37	chr2	232262645	232262645	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaagatgtggctgcgcccaCgcccatggcctctcaggggc	14	14	1	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr2:232262645C>T	uc002vrs.2	+	2	395	c.215C>T	c.(214-216)ACG>ATG	p.T72M		NM_145236	NP_660279	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal	72	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		GCTGCGCCCACGCCCATGGCC	0.617													T	232262645	T	T	232262645	3	4	17	1	0	0	0	0	1	0	0	0	1262	536	19	1	221	1	B3GNT7	2	232262645	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	7396180	232262645	10936728	17	1115											
SCN5A	6331	broad.mit.edu	37	chr3	38592883	38592883	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acgaggaagagcagcagcccGatgttgaagagggcaggcag	17	8	0	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr3:38592883G>A	uc003cio.2	-	28	5174	c.4980C>T	c.(4978-4980)ATC>ATT	p.I1660I	SCN5A_uc003cin.2_Silent_p.I1659I|SCN5A_uc003cil.3_Silent_p.I1660I|SCN5A_uc010hhi.2_Silent_p.I1642I|SCN5A_uc010hhk.2_Silent_p.I1627I|SCN5A_uc011ayr.1_Silent_p.I1606I	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1660	Helical; Name=S5 of repeat IV; (Potential).		I -> V (in BRS1; detected in a compound heterozygote also carrying L-336; the presence of both mutations is necessary for the phenotypic expression of the disease; complete loss of sodium currents due to defective channel trafficking to the plasma membrane).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCAGCAGCCCGATGTTGAAGA	0.567													A	38592883	A	A	38592883	2	1	17	1	0	0	0	0	0	0	0	1	13922	1048	37	2		2	SCN5A	3	38592883	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08		38592883	159429547	18	1116											
SCN10A	6336	broad.mit.edu	37	chr3	38765036	38765036	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctcagaggagcttgtgtcGtccactccctgcaggggaga	13	13	1	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr3:38765036G>A	uc003ciq.2	-	18	3237	c.3237C>T	c.(3235-3237)GAC>GAT	p.D1079D		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1079					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AGCTTGTGTCGTCCACTCCCT	0.512													A	38765036	A	A	38765036	2	1	17	1	0	0	0	0	0	0	0	1	13912	1136	40	1		1	SCN10A	3	38765036	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	172153	38765036	159257394	19	1117											
SCN10A	6336	broad.mit.edu	37	chr3	38770224	38770224	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcgcggagatattttttcGgttgttacggtagttttccc	13	7	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr3:38770224G>A	uc003ciq.2	-	15	2449	c.2449C>T	c.(2449-2451)CGA>TGA	p.R817*		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	817	II.				sensory perception	voltage-gated sodium channel complex		p.R817*(1)		ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ATATTTTTTCGGTTGTTACGG	0.532													A	38770224	A	A	38770224	4	1	17	1	0	0	0	0	0	1	0	0	13912	1124	39	2	3473	2	SCN10A	3	38770224	Nonsense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	5188	38770224	159252206	20	1118											
EPHA6	285220	broad.mit.edu	37	chr3	96706525	96706525	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcaaactcaacactgaaattCgtgaggtggggcctatagaa	10	8	2	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr3:96706525C>T	uc010how.1	+	3	845	c.802C>T	c.(802-804)CGT>TGT	p.R268C	EPHA6_uc003drp.1_Missense_Mutation_p.R268C	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	173	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.R174C(1)		stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CACTGAAATTCGTGAGGTGGG	0.443													T	96706525	T	T	96706525	3	4	17	1	0	0	0	0	1	0	0	0	5171	884	31	2	812	2	EPHA6	3	96706525	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	57936301	96706525	101315905	21	1119											
TMPRSS7	344805	broad.mit.edu	37	chr3	111782428	111782428	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatgtgtccctcaggcccagCgttgtgatggagtaaatgac	12	9	1	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr3:111782428C>T	uc010hqb.2	+	10	1296	c.1126C>T	c.(1126-1128)CGT>TGT	p.R376C	TMPRSS7_uc011bhr.1_Missense_Mutation_p.R231C	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	502	LDL-receptor class A 1.|Extracellular (Potential).				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						TCAGGCCCAGCGTTGTGATGG	0.383													T	111782428	T	T	111782428	3	4	17	1	0	0	0	0	1	0	0	0	16249	768	27	1	1160	1	TMPRSS7	3	111782428	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	15075903	111782428	86240002	22	1120											
POLQ	10721	broad.mit.edu	37	chr3	121212455	121212455	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agcatttagtaaggatacccGaaccaggtcacacagctccc	8	13	1	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr3:121212455G>T	uc003eee.3	-	15	2521	c.2392C>A	c.(2392-2394)CGG>AGG	p.R798R	POLQ_uc003eed.2_5'Flank	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	798					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAGGATACCCGAACCAGGTCA	0.488								DNA_polymerases_(catalytic_subunits)					T	121212455	T	T	121212455	2	4	17	1	0	0	0	0	0	0	0	1	12208	1057	37	5		5	POLQ	3	121212455	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	9430027	121212455	76809975	23	1121											
AGTR1	185	broad.mit.edu	37	chr3	148459240	148459240	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatgaagtcccgccttcgaCgcacaatgcttgtagccaaa	8	13	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr3:148459240C>T	uc003ewg.2	+	4	864	c.418C>T	c.(418-420)CGC>TGC	p.R140C	AGTR1_uc003ewh.2_Missense_Mutation_p.R140C|AGTR1_uc003ewi.2_Missense_Mutation_p.R140C|AGTR1_uc003ewj.2_Missense_Mutation_p.R140C|AGTR1_uc003ewk.2_Missense_Mutation_p.R140C	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	140	Cytoplasmic (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	CCGCCTTCGACGCACAATGCT	0.473													T	148459240	T	T	148459240	3	4	17	1	0	0	0	0	1	0	0	0	401	536	19	1	420	1	AGTR1	3	148459240	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	27246785	148459240	49563190	24	1122											
RTP2	344892	broad.mit.edu	37	chr3	187416724	187416724	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgagcccgcccgctgggcGcggtccaggaacatgtggaa	15	14	0	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr3:187416724G>A	uc003fro.1	-	2	669	c.240C>T	c.(238-240)CGC>CGT	p.R80R		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	80	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		CCCGCTGGGCGCGGTCCAGGA	0.657													A	187416724	A	A	187416724	2	1	17	1	0	0	0	0	0	0	0	1	13734	1074	38	1		1	RTP2	3	187416724	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	38957484	187416724	10605706	25	1123											
TLR6	10333	broad.mit.edu	37	chr4	38830432	38830432	+	Frame_Shift_Del	DEL	C	-	-													atattagtcagttgtaagcaCcctaaagtattaactgatat					rs146892714		TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr4:38830432delC	uc003gtm.2	-	1	729	c.663delG	c.(661-663)GGGfs	p.G221fs	TLR6_uc010ifg.1_Frame_Shift_Del_p.G221fs	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	221	Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						GTTGTAAGCACCCTAAAGTAT	0.323													-	38830432	-	-	38830432	7	5	17	1	0	1	0	1	0	0	0	0	15952	494	18	0	1731	0	TLR6	4	38830432	Frame_Shift_Del	DEL	C	TCGA-06-0137-01A-01D-1490-08		38830432	152323844	26	1124											
TMEM156	80008	broad.mit.edu	37	chr4	39000377	39000377	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcaagtcctggtgaagttacGaaaattggagggatttagaa	13	4	0	2	rs13118782		TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr4:39000377G>A	uc003gto.2	-	2	349	c.241C>T	c.(241-243)CGT>TGT	p.R81C	TMEM156_uc010ifj.2_Missense_Mutation_p.R81C	NM_024943	NP_079219	Q8N614	TM156_HUMAN	transmembrane protein 156	81	Extracellular (Potential).					integral to membrane				skin(1)	1						GTGAAGTTACGAAAATTGGAG	0.368													A	39000377	A	A	39000377	3	1	17	1	0	0	0	0	1	0	0	0	16070	1058	37	2	669	2	TMEM156	4	39000377	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	169945	39000377	152153899	27	1125											
RAI14	26064	broad.mit.edu	37	chr5	34823835	34823835	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagtgatgaagctgaggacAtgaaagaagccatgaatagg	13	6	0	6			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr5:34823835A>G	uc003jir.2	+	15	2084	c.1888A>G	c.(1888-1890)ATG>GTG	p.M630V	RAI14_uc010iur.2_Missense_Mutation_p.M601V|RAI14_uc011coj.1_Missense_Mutation_p.M630V|RAI14_uc003jis.2_Missense_Mutation_p.M633V|RAI14_uc003jit.2_Missense_Mutation_p.M630V|RAI14_uc011cok.1_Missense_Mutation_p.M622V	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	630	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					AGCTGAGGACATGAAAGAAGC	0.418													G	34823835	G	G	34823835	3	3	17	1	0	0	0	0	1	0	0	0	13008	217	8	4	2007	4	RAI14	5	34823835	Missense_Mutation	SNP	A	TCGA-06-0137-01A-01D-1490-08		34823835	146091425	28	1126											
UGT3A2	167127	broad.mit.edu	37	chr5	36035966	36035966	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agacatagggcttgaggtgcGtcgcgccccctgtctggagg	16	11	1	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr5:36035966G>A	uc003jjz.1	-	7	1499	c.1406C>T	c.(1405-1407)ACG>ATG	p.T469M	UGT3A2_uc011cos.1_Missense_Mutation_p.T435M|UGT3A2_uc011cot.1_Missense_Mutation_p.T167M	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	469	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTTGAGGTGCGTCGCGCCCCC	0.627													A	36035966	A	A	36035966	3	1	17	1	0	0	0	0	1	0	0	0	16961	1145	40	1	169	1	UGT3A2	5	36035966	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	1212131	36035966	144879294	29	1127											
HEATR7B2	133558	broad.mit.edu	37	chr5	41067251	41067251	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagcataataaatcaatcGttggacaattgcatcatcca	6	8	2	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr5:41067251G>A	uc003jmj.3	-	3	650	c.160C>T	c.(160-162)CGA>TGA	p.R54*		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	54	HEAT 1.						binding			ovary(6)|central_nervous_system(2)	8						TAAATCAATCGTTGGACAATT	0.373													A	41067251	A	A	41067251	4	1	17	1	0	0	0	0	0	1	0	0	7035	1153	40	1	4757	1	HEATR7B2	5	41067251	Nonsense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	5031285	41067251	139848009	30	1128											
SLC27A6	28965	broad.mit.edu	37	chr5	128302221	128302221	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctcgccaagctgggctgcGtggtggcctttctcaacacc	12	15	1	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr5:128302221G>A	uc003kuy.2	+	2	787	c.391G>A	c.(391-393)GTG>ATG	p.V131M	SLC27A6_uc003kuz.2_Missense_Mutation_p.V131M	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	131	Helical; (Potential).				long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GCTGGGCTGCGTGGTGGCCTT	0.592													A	128302221	A	A	128302221	3	1	17	1	0	0	0	0	1	0	0	0	14530	1145	40	1	393	1	SLC27A6	5	128302221	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	87234970	128302221	52613039	31	1129											
ABLIM3	22885	broad.mit.edu	37	chr5	148637854	148637854	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctgccctgcctccttcagCgccacctgtcccaggaagag	10	18	1	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr5:148637854C>T	uc003lpy.2	+	24	2190	c.1939C>T	c.(1939-1941)CGC>TGC	p.R647C	ABLIM3_uc003lpz.1_Missense_Mutation_p.R647C|ABLIM3_uc003lqa.1_Missense_Mutation_p.R544C|ABLIM3_uc003lqb.2_Intron|ABLIM3_uc003lqc.1_Missense_Mutation_p.R614C|ABLIM3_uc003lqd.1_Missense_Mutation_p.R552C|ABLIM3_uc003lqf.2_Intron|ABLIM3_uc003lqe.1_Missense_Mutation_p.R536C	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	647	HP.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCCTTCAGCGCCACCTGTC	0.507													T	148637854	T	T	148637854	3	4	17	1	0	0	0	0	1	0	0	0	96	782	27	1	2029	1	ABLIM3	5	148637854	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	20335633	148637854	32277406	32	1130											
DOCK2	1794	broad.mit.edu	37	chr5	169108785	169108785	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgattgtcagagatgaagacGgaaatatcttggaccctgat	11	6	2	5			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr5:169108785G>A	uc003maf.2	+	7	588	c.508G>A	c.(508-510)GGA>AGA	p.G170R	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	170					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATGAAGACGGAAATATCTT	0.413													A	169108785	A	A	169108785	3	1	17	1	0	0	0	0	1	0	0	0	4687	1117	39	2	534	2	DOCK2	5	169108785	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	20470931	169108785	11806475	33	1131											
C6orf153	88745	broad.mit.edu	37	chr6	42993026	42993026	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggaaatgtcagccaagatcCgagtaccatttttacgtcag	9	9	2	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr6:42993026C>A	uc003otp.1	+	3	312	c.304C>A	c.(304-306)CGA>AGA	p.R102R		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	102					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AGCCAAGATCCGAGTACCATT	0.338													A	42993026	A	A	42993026	2	1	17	1	0	0	0	0	0	0	0	1	2338	644	23	5		5	C6orf153	6	42993026	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08		42993026	128122041	34	1132											
HCRTR2	3062	broad.mit.edu	37	chr6	55120034	55120034	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttaagagcacagcaaagcGggcccgtaacagcattgtca	11	10	1	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr6:55120034G>A	uc003pcl.2	+	3	818	c.503G>A	c.(502-504)CGG>CAG	p.R168Q	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.R103Q	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	168	Cytoplasmic (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity	p.R168W(1)		ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ACAGCAAAGCGGGCCCGTAAC	0.517													A	55120034	A	A	55120034	3	1	17	1	0	0	0	0	1	0	0	0	7002	1116	39	2	513	2	HCRTR2	6	55120034	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	12127008	55120034	115995033	35	1133											
COL19A1	1310	broad.mit.edu	37	chr6	70840111	70840111	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctggaggcctgaaaggagAcaaggtaatcagattttttt	12	5	1	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr6:70840111A>G	uc003pfc.1	+	18	1496	c.1379A>G	c.(1378-1380)GAC>GGC	p.D460G	COL19A1_uc010kam.1_Missense_Mutation_p.D356G	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	460	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						CTGAAAGGAGACAAGGTAATC	0.199													G	70840111	G	G	70840111	3	3	17	1	0	0	0	0	1	0	0	0	3676	275	10	4	1445	4	COL19A1	6	70840111	Missense_Mutation	SNP	A	TCGA-06-0137-01A-01D-1490-08	15720077	70840111	100274956	36	1134											
ZNF292	23036	broad.mit.edu	37	chr6	87967291	87967291	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctttctaaaggggggtaatgGtgaaaatgcagtttttcctt	11	5	1	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr6:87967291G>C	uc003plm.3	+	8	3985	c.3944G>C	c.(3943-3945)GGT>GCT	p.G1315A		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GGGGGTAATGGTGAAAATGCA	0.383													C	87967291	C	C	87967291	3	2	17	1	0	0	0	0	1	0	0	0	17823	1261	44	5	3974	5	ZNF292	6	87967291	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	17127180	87967291	83147776	37	1135											
IQCE	23288	broad.mit.edu	37	chr7	2611946	2611946	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagaggccacatctcaggcGctctgccagcaacggtgagc	13	13	2	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr7:2611946G>A	uc003smo.3	+	5	564	c.380G>A	c.(379-381)CGC>CAC	p.R127H	IQCE_uc010ksm.1_Missense_Mutation_p.R127H|IQCE_uc003sml.1_Missense_Mutation_p.R127H|IQCE_uc011jvy.1_Missense_Mutation_p.R111H|IQCE_uc011jvz.1_Missense_Mutation_p.R62H|IQCE_uc003smk.3_Missense_Mutation_p.R111H|IQCE_uc003smn.3_Missense_Mutation_p.R62H	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	127											0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		CATCTCAGGCGCTCTGCCAGC	0.617													A	2611946	A	A	2611946	3	1	17	1	0	0	0	0	1	0	0	0	7806	1087	38	1	398	1	IQCE	7	2611946	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08		2611946	156526717	38	1136											
OGDH	4967	broad.mit.edu	37	chr7	44736643	44736643	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attcggctgagcggccaggaCgtggagcggggcacattcag	17	10	1	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr7:44736643C>T	uc003tln.2	+	15	2140	c.2031C>T	c.(2029-2031)GAC>GAT	p.D677D	OGDH_uc011kbx.1_Silent_p.D673D|OGDH_uc011kby.1_Silent_p.D527D|OGDH_uc003tlp.2_Silent_p.D688D|OGDH_uc011kbz.1_Silent_p.D472D|OGDH_uc003tlo.1_Silent_p.D510D	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	677					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GCGGCCAGGACGTGGAGCGGG	0.552													T	44736643	T	T	44736643	2	4	17	1	0	0	0	0	0	0	0	1	10839	535	19	1		1	OGDH	7	44736643	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	42124697	44736643	114402020	39	1137											
EGFR	1956	broad.mit.edu	37	chr7	55233037	55233037	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccactgcgtcaagacctgccCggcaggagtcatgggagaaa	13	12	2	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr7:55233037C>T	uc003tqk.2	+	15	2033	c.1787C>T	c.(1786-1788)CCG>CTG	p.P596L	EGFR_uc003tqi.2_Missense_Mutation_p.P596L|EGFR_uc003tqj.2_Missense_Mutation_p.P596L|EGFR_uc010kzg.1_Missense_Mutation_p.P551L|EGFR_uc011kco.1_Missense_Mutation_p.P543L|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	596	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.P596L(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAGACCTGCCCGGCAGGAGTC	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233037	T	T	55233037	3	4	17	1	0	0	0	0	1	0	0	0	4967	652	23	2	1856	2	EGFR	7	55233037	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	10496394	55233037	103905626	40	1138											
ZNF716	441234	broad.mit.edu	37	chr7	57529294	57529294	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tcataagaggattcatactgGagagaaaccctacacttgtg	9	8	2	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr7:57529294G>T	uc011kdi.1	+	4	1239	c.1127G>T	c.(1126-1128)GGA>GTA	p.G376V		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						ATTCATACTGGAGAGAAACCC	0.413													T	57529294	T	T	57529294	3	4	17	1	0	0	0	0	1	0	0	0	18116	1174	41	5	1141	5	ZNF716	7	57529294	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	2296257	57529294	101609369	41	1139											
GTF2IRD2	84163	broad.mit.edu	37	chr7	74234528	74234528	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgatactatggatctctcCgcatctgttaccatcccagg	9	12	2	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr7:74234528C>T	uc003ubd.1	-	7	781	c.597G>A	c.(595-597)GCG>GCA	p.A199A	GTF2IRD2_uc011kfi.1_Silent_p.A199A|uc003ube.1_5'Flank|GTF2IRD2_uc003ubf.1_Silent_p.A199A	NM_173537	NP_775808	Q86UP8	GTD2A_HUMAN	GTF2I repeat domain containing 2	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGGATCTCTCCGCATCTGTTA	0.443													T	74234528	T	T	74234528	2	4	17	1	0	0	0	0	0	0	0	1	6869	639	23	2		2	GTF2IRD2	7	74234528	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	16705234	74234528	84904135	42	1140											
PCLO	27445	broad.mit.edu	37	chr7	82763627	82763627	+	Frame_Shift_Del	DEL	G	-	-													acacttgattcttgcattcaGtgcaagtattgaagttagga							TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr7:82763627delG	uc003uhx.2	-	3	3528	c.3239delC	c.(3238-3240)ACTfs	p.T1080fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.T1080fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1026	C4-type (Potential).				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTTGCATTCAGTGCAAGTATT	0.348													-	82763627	-	-	82763627	7	5	17	1	0	1	0	1	0	0	0	0	11583	1029	36	0	12298	0	PCLO	7	82763627	Frame_Shift_Del	DEL	G	TCGA-06-0137-01A-01D-1490-08	8529099	82763627	76375036	43	1141											
PTN	5764	broad.mit.edu	37	chr7	136938378	136938378	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cacagtcagacttcttcactTttttttctgaatgaaaggag	7	8	4	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr7:136938378T>A	uc003vtq.2	-	3	485	c.122A>T	c.(121-123)AAA>ATA	p.K41I	PTN_uc010lmx.2_Missense_Mutation_p.K41I|PTN_uc003vtr.1_Missense_Mutation_p.K41I	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	41					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2						CTTCTTCACTTTTTTTTCTGA	0.428													A	136938378	A	A	136938378	3	1	17	1	0	0	0	0	1	0	0	0	12768	1841	64	5	396	5	PTN	7	136938378	Missense_Mutation	SNP	T	TCGA-06-0137-01A-01D-1490-08	54174751	136938378	22200285	44	1142											
ATP6V0A4	50617	broad.mit.edu	37	chr7	138440463	138440463	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcttccagcctcacattgaCgctctccaacatctctctgc	4	17	5	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr7:138440463C>T	uc003vuf.2	-	9	1025	c.787G>A	c.(787-789)GTC>ATC	p.V263I	ATP6V0A4_uc003vug.2_Missense_Mutation_p.V263I|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.V263I	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	263	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						CTCACATTGACGCTCTCCAAC	0.522													T	138440463	T	T	138440463	3	4	17	1	0	0	0	0	1	0	0	0	1170	536	19	1	1787	1	ATP6V0A4	7	138440463	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	1502085	138440463	20698200	45	1143											
DLGAP2	9228	broad.mit.edu	37	chr8	1497705	1497705	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggttggcgctgacgcccgaCgccaagtacctgaagcgcag	15	13	0	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr8:1497705C>T	uc003wpl.2	+	2	943	c.846C>T	c.(844-846)GAC>GAT	p.D282D	DLGAP2_uc003wpm.2_Silent_p.D282D	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	361					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TGACGCCCGACGCCAAGTACC	0.647													T	1497705	T	T	1497705	2	4	17	1	0	0	0	0	0	0	0	1	4560	535	19	1		1	DLGAP2	8	1497705	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08		1497705	144866317	46	1144											
KCNV1	27012	broad.mit.edu	37	chr8	110984522	110984522	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccagctttagcatgcgcagaGccctgagcagcctcaacacc	9	16	1	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr8:110984522G>T	uc003ynr.3	-	2	1298	c.956C>A	c.(955-957)GCT>GAT	p.A319D	KCNV1_uc010mcw.2_Missense_Mutation_p.A319D	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	319	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CATGCGCAGAGCCCTGAGCAG	0.502													T	110984522	T	T	110984522	3	4	17	1	0	0	0	0	1	0	0	0	8094	971	34	5	554	5	KCNV1	8	110984522	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	109486817	110984522	35379500	47	1145											
CSMD3	114788	broad.mit.edu	37	chr8	113988211	113988211	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agacctgaatttctgagactCgtaacttgcactcgctgttc	8	11	1	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr8:113988211C>T	uc003ynu.2	-	7	1356	c.1197G>A	c.(1195-1197)ACG>ACA	p.T399T	CSMD3_uc003ynt.2_Silent_p.T359T|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	399	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTCTGAGACTCGTAACTTGCA	0.502										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			T	113988211	T	T	113988211	2	4	17	1	0	0	0	0	0	0	0	1	3946	871	31	2		2	CSMD3	8	113988211	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	3003689	113988211	32375811	48	1146											
GABBR2	9568	broad.mit.edu	37	chr9	101235479	101235479	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaggggctcgaaatccacGccaatgtagccctccatggc	10	15	1	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr9:101235479G>A	uc004ays.2	-	6	1104	c.948C>T	c.(946-948)GGC>GGT	p.G316G		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	316	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	CGAAATCCACGCCAATGTAGC	0.572													A	101235479	A	A	101235479	2	1	17	1	0	0	0	0	0	0	0	1	6156	1074	38	1		1	GABBR2	9	101235479	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08		101235479	39977952	49	1147											
TSC1	7248	broad.mit.edu	37	chr9	135804224	135804224	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agcatgggggagtccagcatGgcaagaagctccccgacatt	13	11	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr9:135804224G>T	uc004cca.2	-	3	270	c.36C>A	c.(34-36)GCC>GCA	p.A12A	TSC1_uc004ccb.3_Silent_p.A12A|TSC1_uc011mcq.1_Silent_p.A12A|TSC1_uc011mcr.1_Intron|TSC1_uc011mcs.1_5'UTR|TSC1_uc004ccc.1_Silent_p.A12A|TSC1_uc004ccd.2_Silent_p.A12A|TSC1_uc004cce.1_Silent_p.A12A	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	12					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.A12A(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		AGTCCAGCATGGCAAGAAGCT	0.502			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				T	135804224	T	T	135804224	2	4	17	1	0	0	0	0	0	0	0	1	16602	1335	47	5		5	TSC1	9	135804224	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	34568745	135804224	5409207	50	1148											
LCN1	3933	broad.mit.edu	37	chr9	138415812	138415812	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggcgagctgcacgggaagCcggtccgaggggtgaagctc	19	10	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr9:138415812C>T	uc004cfz.1	+	4	437	c.379C>T	c.(379-381)CCG>TCG	p.P127S	LCN1_uc004cga.1_Missense_Mutation_p.P127S	NM_002297	NP_002288	P31025	LCN1_HUMAN	lipocalin 1 precursor	127					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		GCACGGGAAGCCGGTCCGAGG	0.632													T	138415812	T	T	138415812	3	4	17	1	0	0	0	0	1	0	0	0	8680	739	26	3	393	3	LCN1	9	138415812	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	2611588	138415812	2797619	51	1149											
OR52K1	390036	broad.mit.edu	37	chr11	4511035	4511035	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtcaagaccaagcagattcGtgagtatgtgctcagtctat	10	8	3	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr11:4511035G>A	uc001lza.1	+	1	905	c.905G>A	c.(904-906)CGT>CAT	p.R302H		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		AAGCAGATTCGTGAGTATGTG	0.433													A	4511035	A	A	4511035	3	1	17	1	0	0	0	0	1	0	0	0	11123	1145	40	1	907	1	OR52K1	11	4511035	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08		4511035	130495481	52	1150											
OR51F1	256892	broad.mit.edu	37	chr11	4790947	4790947	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cccagatcagtggctgatagCctgaagaggaaataatacat	10	8	1	4			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr11:4790947C>A	uc010qyl.1	-	1	201	c.201G>T	c.(199-201)AGG>AGT	p.R67S		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	67						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		TGGCTGATAGCCTGAAGAGGA	0.443													A	4790947	A	A	4790947	3	1	17	1	0	0	0	0	1	0	0	0	11096	738	26	5	740	5	OR51F1	11	4790947	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	279912	4790947	130215569	53	1151											
RBMXL2	27288	broad.mit.edu	37	chr11	7111041	7111041	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gactaccgcgaaccccggggTtttgccccctcgcccggaga	12	17	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr11:7111041T>G	uc001mfc.2	+	1	877	c.690T>G	c.(688-690)GGT>GGG	p.G230G		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	230	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AACCCCGGGGTTTTGCCCCCT	0.692													G	7111041	G	G	7111041	2	3	17	1	0	0	0	0	0	0	0	1	13154	1712	60	5		5	RBMXL2	11	7111041	Silent	SNP	T	TCGA-06-0137-01A-01D-1490-08	2320094	7111041	127895475	54	1152											
PLEKHA7	144100	broad.mit.edu	37	chr11	16838834	16838834	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaggacagggattggccaGgaccctggcgaggaagcgtc	18	9	0	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr11:16838834G>A	uc001mmo.2	-	11	1394	c.1379C>T	c.(1378-1380)CCT>CTT	p.P460L	PLEKHA7_uc010rcu.1_Missense_Mutation_p.P460L|PLEKHA7_uc010rcv.1_Missense_Mutation_p.P34L|PLEKHA7_uc001mmn.2_Missense_Mutation_p.P168L	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	460					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						GGATTGGCCAGGACCCTGGCG	0.602													A	16838834	A	A	16838834	3	1	17	1	0	0	0	0	1	0	0	0	12061	1000	35	3	2038	3	PLEKHA7	11	16838834	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	9727793	16838834	118167682	55	1153											
CD44	960	broad.mit.edu	37	chr11	35227763	35227763	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatctcacaccccatgggaCgaggtcatcaagcaggaaga	10	12	3	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr11:35227763C>T	uc001mvu.2	+	11	1821	c.1387C>T	c.(1387-1389)CGA>TGA	p.R463*	CD44_uc001mvv.2_Nonsense_Mutation_p.R420*|CD44_uc001mvw.2_Intron|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Intron|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron|CD44_uc010res.1_Nonsense_Mutation_p.R27*|CD44_uc010ret.1_Intron|CD44_uc010reu.1_Intron	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	463	Extracellular (Potential).|Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	CCCCATGGGACGAGGTCATCA	0.443													T	35227763	T	T	35227763	4	4	17	1	0	0	0	0	0	1	0	0	3017	528	19	1	1429	1	CD44	11	35227763	Nonsense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	18388929	35227763	99778753	56	1154											
OR4C16	219428	broad.mit.edu	37	chr11	55339695	55339695	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgtttgttatttttttgcGtctctacttgggaacactgt	9	6	1	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr11:55339695G>A	uc010rih.1	+	1	92	c.92G>A	c.(91-93)CGT>CAT	p.R31H		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				ATTTTTTTGCGTCTCTACTTG	0.368													A	55339695	A	A	55339695	3	1	17	1	0	0	0	0	1	0	0	0	11049	1145	40	1	94	1	OR4C16	11	55339695	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	20111932	55339695	79666821	57	1155											
FOLR1	2348	broad.mit.edu	37	chr11	71906672	71906672	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggtggatcagagctggcGcaaagagcgggtactgaacg	16	9	1	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr11:71906672G>A	uc001orz.1	+	5	512	c.374G>A	c.(373-375)CGC>CAC	p.R125H	FOLR1_uc001osa.1_Missense_Mutation_p.R125H|FOLR1_uc001osb.1_Missense_Mutation_p.R125H|FOLR1_uc001osc.1_Missense_Mutation_p.R125H|FOLR1_uc001osd.1_Missense_Mutation_p.R125H	NM_016724	NP_057936	P15328	FOLR1_HUMAN	folate receptor 1 precursor	125					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			ovary(1)	1						CAGAGCTGGCGCAAAGAGCGG	0.537													A	71906672	A	A	71906672	3	1	17	1	0	0	0	0	1	0	0	0	5981	1087	38	1	384	1	FOLR1	11	71906672	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	16566977	71906672	63099844	58	1156											
PIK3C2G	5288	broad.mit.edu	37	chr12	18576934	18576934	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgcaacttctactccaccGctccttgcagagcatccagg	8	15	1	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr12:18576934G>A	uc001rdt.2	+	17	2458	c.2342G>A	c.(2341-2343)CGC>CAC	p.R781H	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.R822H|PIK3C2G_uc010sic.1_Missense_Mutation_p.R600H	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	781					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.R781H(1)		lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CTACTCCACCGCTCCTTGCAG	0.428													A	18576934	A	A	18576934	3	1	17	1	0	0	0	0	1	0	0	0	11911	1087	38	1	2404	1	PIK3C2G	12	18576934	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08		18576934	115274961	59	1157											
ABCD2	225	broad.mit.edu	37	chr12	40012537	40012538	+	Frame_Shift_Ins	INS	-	A	A													tataattctcgagtgcacatINSaccgcaaatagccttttcta							TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr12:40012537_40012538insA	uc001rmb.2	-	1	1306_1307	c.880_881insT	c.(880-882)TATfs	p.Y294fs		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	294	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						CGAGTGCACATACCGCAAATAG	0.406													A	40012538	A	A	40012537	7	5	17	1	0	1	1	0	0	0	0	0	61	1406	49	0	1381	0	ABCD2	12	40012537	Frame_Shift_Ins	INS	-	TCGA-06-0137-01A-01D-1490-08	21435603	40012537	93839358	60	1158											
AMDHD1	144193	broad.mit.edu	37	chr12	96354263	96354263	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagaaatggggaaatacaCgtggacaatatagacgtatt	12	5	0	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr12:96354263C>T	uc001tel.1	+	5	781	c.675C>T	c.(673-675)CAC>CAT	p.H225H	AMDHD1_uc009zth.1_Silent_p.H116H	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	225					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1						GGGAAATACACGTGGACAATA	0.413													T	96354263	T	T	96354263	2	4	17	1	0	0	0	0	0	0	0	1	567	535	19	1		1	AMDHD1	12	96354263	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	56341726	96354263	37497632	61	1159											
DAO	1610	broad.mit.edu	37	chr12	109293195	109293195	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaactggcttccggccagtaCgcccccagattcggctagaa	11	14	0	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr12:109293195C>T	uc001tnr.3	+	10	1009	c.856C>T	c.(856-858)CGC>TGC	p.R286C	DAO_uc001tnq.3_Missense_Mutation_p.R220C|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	286					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2						CCGGCCAGTACGCCCCCAGAT	0.468													T	109293195	T	T	109293195	3	4	17	1	0	0	0	0	1	0	0	0	4231	536	19	1	890	1	DAO	12	109293195	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	12938932	109293195	24558700	62	1160											
NOS1	4842	broad.mit.edu	37	chr12	117768667	117768667	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcaggtccaccaagggccGgccgttgaccgcaagaatga	13	13	1	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr12:117768667G>A	uc001twm.1	-	2	894	c.208C>T	c.(208-210)CGG>TGG	p.R70W		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	70	Interaction with NOSIP (By similarity).|PDZ.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	ACCAAGGGCCGGCCGTTGACC	0.612													A	117768667	A	A	117768667	3	1	17	1	0	0	0	0	1	0	0	0	10541	1115	39	2	4208	2	NOS1	12	117768667	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	8475472	117768667	16083228	63	1161											
OR4N5	390437	broad.mit.edu	37	chr14	20612259	20612259	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgttgtgatggcctttgaccGctacatcgccatctgccggc	11	14	1	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr14:20612259G>A	uc010tla.1	+	1	365	c.365G>A	c.(364-366)CGC>CAC	p.R122H		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GCCTTTGACCGCTACATCGCC	0.478													A	20612259	A	A	20612259	3	1	17	1	0	0	0	0	1	0	0	0	11079	1087	38	1	367	1	OR4N5	14	20612259	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08		20612259	86737281	64	1162											
MYH6	4624	broad.mit.edu	37	chr14	23855760	23855760	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttctctgccagcttccgctCgatctctgccttgatctggt	8	15	3	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr14:23855760C>T	uc001wjv.2	-	33	4790	c.4723G>A	c.(4723-4725)GAG>AAG	p.E1575K		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1575	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		AGCTTCCGCTCGATCTCTGCC	0.647													T	23855760	T	T	23855760	3	4	17	1	0	0	0	0	1	0	0	0	10038	893	31	2	1124	2	MYH6	14	23855760	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	3243501	23855760	83493780	65	1163											
ATL1	51062	broad.mit.edu	37	chr14	51080061	51080061	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgccaaattcttggaaaaaCgcctcaaggtttgttagata	9	7	2	1	rs119476046		TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr14:51080061C>T	uc001wyf.3	+	7	956	c.715C>T	c.(715-717)CGC>TGC	p.R239C	ATL1_uc001wyd.3_Missense_Mutation_p.R239C|ATL1_uc001wye.3_Missense_Mutation_p.R239C	NM_015915	NP_056999	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1 isoform a	239	Cytoplasmic.		R -> C (in SPG3; affects endoplasmic reticulum and Golgi morphology).		axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			skin(3)|central_nervous_system(1)	4						CTTGGAAAAACGCCTCAAGGT	0.353													T	51080061	T	T	51080061	3	4	17	1	0	0	0	0	1	0	0	0	1106	536	19	1	741	1	ATL1	14	51080061	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	27224301	51080061	56269479	66	1164											
CLMN	79789	broad.mit.edu	37	chr14	95677055	95677055	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagcctggggatgtgcaggGcatcctgtgcgatgctgaaa	17	8	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr14:95677055G>A	uc001yef.2	-	7	886	c.770C>T	c.(769-771)GCC>GTC	p.A257V		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	257	Actin-binding.|CH 2.					integral to membrane	actin binding				0				Epithelial(152;0.193)		GATGTGCAGGGCATCCTGTGC	0.418													A	95677055	A	A	95677055	3	1	17	1	0	0	0	0	1	0	0	0	3542	1203	42	3	2266	3	CLMN	14	95677055	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	44596994	95677055	11672485	67	1165											
RYR3	6263	broad.mit.edu	37	chr15	33895522	33895522	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaggcaatggtgttggtgaCgacctgtactcctatggctt	14	8	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr15:33895522C>T	uc001zhi.2	+	18	2191	c.2121C>T	c.(2119-2121)GAC>GAT	p.D707D	RYR3_uc010bar.2_Silent_p.D707D	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	707	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.D707D(1)		ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTGTTGGTGACGACCTGTACT	0.537													T	33895522	T	T	33895522	2	4	17	1	0	0	0	0	0	0	0	1	13770	535	19	1		1	RYR3	15	33895522	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08		33895522	68635870	68	1166											
PLCB2	5330	broad.mit.edu	37	chr15	40583828	40583828	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cgcagcttctttcatagcctCttccctggccccggccctgg	9	18	3	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr15:40583828C>T	uc001zld.2	-	25	2927	c.2626G>A	c.(2626-2628)GAG>AAG	p.E876K	PLCB2_uc001zlc.2_5'Flank|PLCB2_uc010bbo.2_Missense_Mutation_p.E872K|PLCB2_uc010ucm.1_Intron	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	876					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		TTCATAGCCTCTTCCCTGGCC	0.706													T	40583828	T	T	40583828	3	4	17	1	0	0	0	0	1	0	0	0	12028	922	32	3	963	3	PLCB2	15	40583828	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	6688306	40583828	61947564	69	1167											
A2BP1	54715	broad.mit.edu	37	chr16	7726795	7726795	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtggttatgctgcataccGctacgcccagcctacccctg	11	15	0	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr16:7726795G>A	uc002cys.2	+	14	1938	c.950G>A	c.(949-951)CGC>CAC	p.R317H	A2BP1_uc002cyt.2_Missense_Mutation_p.R290H|A2BP1_uc010uxz.1_Missense_Mutation_p.R360H|A2BP1_uc010uya.1_Missense_Mutation_p.R274H|A2BP1_uc010uyb.1_Missense_Mutation_p.R317H|A2BP1_uc002cyw.2_Missense_Mutation_p.R338H|A2BP1_uc002cyy.2_Missense_Mutation_p.R338H|A2BP1_uc002cyx.2_Missense_Mutation_p.R338H|A2BP1_uc010uyc.1_Missense_Mutation_p.R311H	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	317					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		GCTGCATACCGCTACGCCCAG	0.517													A	7726795	A	A	7726795	3	1	17	1	0	0	0	0	1	0	0	0	3	1087	38	1	1130	1	A2BP1	16	7726795	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08		7726795	82627958	70	1168											
ACSM3	6296	broad.mit.edu	37	chr16	20787173	20787173	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttcctcaggctggaaagaaaCcttcaaatccagccttctgg	8	12	3	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr16:20787173C>A	uc002dhr.2	+	3	419	c.232C>A	c.(232-234)CCT>ACT	p.P78T	ACSM3_uc002dhq.2_Missense_Mutation_p.P78T|ACSM3_uc010vba.1_Missense_Mutation_p.P70T	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	78					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						TGGAAAGAAACCTTCAAATCC	0.403													A	20787173	A	A	20787173	3	1	17	1	0	0	0	0	1	0	0	0	185	507	18	5	238	5	ACSM3	16	20787173	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	13060378	20787173	69567580	71	1169											
ITGAM	3684	broad.mit.edu	37	chr16	31338227	31338227	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctaaggcttcccttggaaaCaaactgctcctcaaggccaa	7	13	2	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr16:31338227C>A	uc002ebq.2	+	22	2777	c.2679C>A	c.(2677-2679)AAC>AAA	p.N893K	ITGAM_uc002ebr.2_Missense_Mutation_p.N894K|ITGAM_uc010can.2_Missense_Mutation_p.N299K|ITGAM_uc002ebs.1_Missense_Mutation_p.N299K	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	893	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CCCTTGGAAACAAACTGCTCC	0.478													A	31338227	A	A	31338227	3	1	17	1	0	0	0	0	1	0	0	0	7887	477	17	5	2768	5	ITGAM	16	31338227	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	10551054	31338227	59016526	72	1170											
RRAD	6236	broad.mit.edu	37	chr16	66957764	66957764	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctacctgctcccaaatgtcGtagaccatgagtgatgcctc	8	14	0	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr16:66957764G>A	uc002eqn.2	-	3	581	c.429C>T	c.(427-429)TAC>TAT	p.Y143Y	RRAD_uc002eqo.2_Silent_p.Y143Y	NM_001128850	NP_001122322	P55042	RAD_HUMAN	Ras-related associated with diabetes	143					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		CCCAAATGTCGTAGACCATGA	0.582													A	66957764	A	A	66957764	2	1	17	1	0	0	0	0	0	0	0	1	13671	1140	40	1		1	RRAD	16	66957764	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	35619537	66957764	23396989	73	1171											
CHST5	23563	broad.mit.edu	37	chr16	75564091	75564091	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacgaggacagcaccagcacGtgcacacgatcctcgccgcc	10	18	0	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr16:75564091G>A	uc002fei.2	-	3	1587	c.192C>T	c.(190-192)CAC>CAT	p.H64H	CHST5_uc002fej.1_Silent_p.H70H	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	64	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GCACCAGCACGTGCACACGAT	0.657													A	75564091	A	A	75564091	2	1	17	1	0	0	0	0	0	0	0	1	3407	1136	40	1		1	CHST5	16	75564091	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	8606327	75564091	14790662	74	1172											
KIF2B	84643	broad.mit.edu	37	chr17	51900728	51900728	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatcagggaccagcgtaccGccacgaaatgggttgcgatg	13	12	1	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr17:51900728G>A	uc002iua.2	+	1	490	c.334G>A	c.(334-336)GCC>ACC	p.A112T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	112					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CCAGCGTACCGCCACGAAATG	0.602													A	51900728	A	A	51900728	3	1	17	1	0	0	0	0	1	0	0	0	8298	1087	38	1	336	1	KIF2B	17	51900728	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08		51900728	29294482	75	1173											
UTS2R	2837	broad.mit.edu	37	chr17	80332605	80332605	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggacttcctgaccatgcaCgccagcatcttcacgctgac	8	16	2	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr17:80332605C>T	uc010wvl.1	+	1	405	c.405C>T	c.(403-405)CAC>CAT	p.H135H		NM_018949	NP_061822	Q9UKP6	UR2R_HUMAN	urotensin 2 receptor	135	Helical; Name=3; (Potential).					integral to membrane|plasma membrane				breast(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			TGACCATGCACGCCAGCATCT	0.662													T	80332605	T	T	80332605	2	4	17	1	0	0	0	0	0	0	0	1	17103	535	19	1		1	UTS2R	17	80332605	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	28431877	80332605	862605	76	1174											
POTEC	388468	broad.mit.edu	37	chr18	14537857	14537857	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtgctttggccattaatttAtcttcattgtggacagcata	8	7	2	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr18:14537857A>G	uc010dln.2	-	3	1207	c.753T>C	c.(751-753)GAT>GAC	p.D251D	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	251	ANK 4.									skin(3)	3						CCATTAATTTATCTTCATTGT	0.343													G	14537857	G	G	14537857	2	3	17	1	0	0	0	0	0	0	0	1	12262	446	16	4		4	POTEC	18	14537857	Silent	SNP	A	TCGA-06-0137-01A-01D-1490-08		14537857	63539391	77	1175											
CDH20	28316	broad.mit.edu	37	chr18	59158011	59158011	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggaagagtacactgggacCgaccctttgtatgtcggcaa	12	10	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr18:59158011C>T	uc010dps.1	+	1	237	c.225C>T	c.(223-225)ACC>ACT	p.T75T	CDH20_uc002lif.2_Silent_p.T69T	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	75	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				ACACTGGGACCGACCCTTTGT	0.448													T	59158011	T	T	59158011	2	4	17	1	0	0	0	0	0	0	0	1	3106	639	23	2		2	CDH20	18	59158011	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	44620154	59158011	18919237	78	1176											
FBXO15	201456	broad.mit.edu	37	chr18	71790685	71790685	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaacatggagttggtagccGtgcagtccatactcggggct	13	10	1	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr18:71790685G>A	uc002lle.2	-	8	1164	c.828C>T	c.(826-828)CAC>CAT	p.H276H	FBXO15_uc002llf.2_Silent_p.H352H	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	276										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		GTTGGTAGCCGTGCAGTCCAT	0.443													A	71790685	A	A	71790685	2	1	17	1	0	0	0	0	0	0	0	1	5728	1136	40	1		1	FBXO15	18	71790685	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	12632674	71790685	6286563	79	1177											
RFX2	5990	broad.mit.edu	37	chr19	5997146	5997146	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accaggtagaacatgtactcGtcgtagagcaggcggatgag	14	8	0	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr19:5997146G>A	uc002meb.2	-	16	2207	c.1938C>T	c.(1936-1938)GAC>GAT	p.D646D	RFX2_uc002mec.2_Silent_p.D621D	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6						ACATGTACTCGTCGTAGAGCA	0.662													A	5997146	A	A	5997146	2	1	17	1	0	0	0	0	0	0	0	1	13263	1136	40	1		1	RFX2	19	5997146	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08		5997146	53131837	80	1178											
PRKCSH	5589	broad.mit.edu	37	chr19	11559740	11559740	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctccacagatacgtctaccGcctctgccccttcaagcttg	6	18	3	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr19:11559740G>A	uc002mrt.2	+	15	1613	c.1277G>A	c.(1276-1278)CGC>CAC	p.R426H	PRKCSH_uc002mru.2_Missense_Mutation_p.R423H|PRKCSH_uc010xlz.1_Missense_Mutation_p.R433H|PRKCSH_uc010dya.2_Missense_Mutation_p.R208H|PRKCSH_uc010dyb.2_Missense_Mutation_p.R423H	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1	426	PRKCSH.				innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0						TACGTCTACCGCCTCTGCCCC	0.647													A	11559740	A	A	11559740	3	1	17	1	0	0	0	0	1	0	0	0	12516	1087	38	1	1352	1	PRKCSH	19	11559740	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	5562594	11559740	47569243	81	1179											
ZNF491	126069	broad.mit.edu	37	chr19	11917007	11917007	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccatataaacataaacaacGtaggaaagccttgagccata	7	9	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr19:11917007G>A	uc002mso.1	+	3	524	c.239G>A	c.(238-240)CGT>CAT	p.R80H		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CATAAACAACGTAGGAAAGCC	0.378													A	11917007	A	A	11917007	3	1	17	1	0	0	0	0	1	0	0	0	17939	1145	40	1	241	1	ZNF491	19	11917007	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	357267	11917007	47211976	82	1180											
HSH2D	84941	broad.mit.edu	37	chr19	16259656	16259656	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggcccaagacggggtcccCgagtggttccatggtgcaat	14	12	0	1	rs77723805		TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr19:16259656C>T	uc002ndp.3	+	4	627	c.96C>T	c.(94-96)CCC>CCT	p.P32P	HSH2D_uc002ndr.2_5'UTR|HSH2D_uc010ead.2_RNA	NM_032855	NP_116244	Q96JZ2	HSH2D_HUMAN	hematopoietic SH2 domain containing	32						cytoplasm|nucleus					0						ACGGGGTCCCCGAGTGGTTCC	0.637													T	16259656	T	T	16259656	2	4	17	1	0	0	0	0	0	0	0	1	7400	639	23	2		2	HSH2D	19	16259656	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	4342649	16259656	42869327	83	1181											
LYPD4	147719	broad.mit.edu	37	chr19	42341249	42341249	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaaacaggaggcctaagaCgacaccccaagcaggatctt	11	12	1	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr19:42341249C>T	uc002orp.1	-	5	1693	c.709G>A	c.(709-711)GTC>ATC	p.V237I	LYPD4_uc002orq.1_Missense_Mutation_p.V202I	NM_173506	NP_775777	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4 precursor	237						anchored to membrane|plasma membrane				ovary(1)	1						AGGCCTAAGACGACACCCCAA	0.483													T	42341249	T	T	42341249	3	4	17	1	0	0	0	0	1	0	0	0	9112	536	19	1	35	1	LYPD4	19	42341249	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	26081593	42341249	16787734	84	1182											
PSG7	5676	broad.mit.edu	37	chr19	43430081	43430081	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	attaattgtccaagaatactGtgccggtgggttagagtccg	12	7	0	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr19:43430081G>C	uc002ovl.3	-	6	1189	c.1087C>G	c.(1087-1089)CAG>GAG	p.Q363E	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Missense_Mutation_p.Q276E|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Missense_Mutation_p.Q89E|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.Q276E|PSG7_uc010xwl.1_Missense_Mutation_p.Q241E	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	363	Ig-like C2-type 3.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CAAGAATACTGTGCCGGTGGG	0.458													C	43430081	C	C	43430081	3	2	17	1	0	0	0	0	1	0	0	0	12660	1386	48	5	180	5	PSG7	19	43430081	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	1088832	43430081	15698902	85	1183											
LILRB1	10859	broad.mit.edu	37	chr19	55143564	55143564	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgcccgtgggtcgtcccgCgccatcttctccgtgggccc	12	18	2	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr19:55143564C>T	uc002qgj.2	+	6	877	c.537C>T	c.(535-537)CGC>CGT	p.R179R	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.R179R|LILRB1_uc002qgk.2_Silent_p.R179R|LILRB1_uc002qgm.2_Silent_p.R179R|LILRB1_uc010erq.2_Silent_p.R179R|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	179	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GGTCGTCCCGCGCCATCTTCT	0.577										HNSCC(37;0.09)			T	55143564	T	T	55143564	2	4	17	1	0	0	0	0	0	0	0	1	8790	755	27	1		1	LILRB1	19	55143564	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	11713483	55143564	3985419	86	1184											
C20orf54	113278	broad.mit.edu	37	chr20	744504	744504	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgacgctggaggacaaagaaCgccacgaggcagcaggccat	14	11	0	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr20:744504C>T	uc002wed.3	-	3	1050	c.711G>A	c.(709-711)GCG>GCA	p.A237A	C20orf54_uc002wee.2_Silent_p.A237A	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	237	Helical; (Potential).				sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						GGACAAAGAACGCCACGAGGC	0.617													T	744504	T	T	744504	2	4	17	1	0	0	0	0	0	0	0	1	2114	523	19	1		1	C20orf54	20	744504	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08		744504	62281016	87	1185											
C20orf152	140894	broad.mit.edu	37	chr20	34571988	34571988	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgggcacagttgcaataacCaaggacgaggatggcagcag	14	9	0	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr20:34571988C>A	uc002xes.1	+	5	648	c.492C>A	c.(490-492)ACC>ACA	p.T164T	C20orf152_uc002xer.1_Silent_p.T164T|C20orf152_uc010gfp.1_Intron			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	164	cNMP.										0	Breast(12;0.00631)					TTGCAATAACCAAGGACGAGG	0.532													A	34571988	A	A	34571988	2	1	17	1	0	0	0	0	0	0	0	1	2092	581	21	5		5	C20orf152	20	34571988	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08	33827484	34571988	28453532	88	1186											
KCNG1	3755	broad.mit.edu	37	chr20	49620775	49620775	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaggccatgagcaggatgCcgctcaggatgctgctcagg	16	10	2	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr20:49620775C>T	uc002xwa.3	-	3	1638	c.1343G>A	c.(1342-1344)GGC>GAC	p.G448D		NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	448	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						GAGCAGGATGCCGCTCAGGAT	0.622													T	49620775	T	T	49620775	3	4	17	1	0	0	0	0	1	0	0	0	8027	739	26	3	202	3	KCNG1	20	49620775	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	15048787	49620775	13404745	89	1187											
LAMA5	3911	broad.mit.edu	37	chr20	60887326	60887326	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggtgccacgttcgagagcGccaggcgaaggaagccgtgg	18	11	0	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr20:60887326G>A	uc002ycq.2	-	69	9474	c.9407C>T	c.(9406-9408)GCG>GTG	p.A3136V		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3136	Laminin G-like 3.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTCGAGAGCGCCAGGCGAAG	0.682													A	60887326	A	A	60887326	3	1	17	1	0	0	0	0	1	0	0	0	8609	1087	38	1	1728	1	LAMA5	20	60887326	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	11266551	60887326	2138194	90	1188											
LRRC3	81543	broad.mit.edu	37	chr21	45877207	45877207	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacgtcgtgtactatgtgcGccacaaccaggaggatgccc	11	13	0	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr21:45877207G>A	uc002zfa.2	+	2	973	c.680G>A	c.(679-681)CGC>CAC	p.R227H		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	227						integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		TACTATGTGCGCCACAACCAG	0.662													A	45877207	A	A	45877207	3	1	17	1	0	0	0	0	1	0	0	0	8984	1087	38	1	682	1	LRRC3	21	45877207	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08		45877207	2252688	91	1189											
KRTAP10-10	353333	broad.mit.edu	37	chr21	46057875	46057875	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagcctgcttgctgcaccGcctcctgctgcagaccctcc	9	20	0	1	rs147625145	byFrequency	TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr21:46057875G>A	uc002zfq.2	+	1	603	c.541G>A	c.(541-543)GCC>ACC	p.A181T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	181	15 X 5 AA repeats of C-C-X(3).|12.					keratin filament					0						TTGCTGCACCGCCTCCTGCTG	0.642													A	46057875	A	A	46057875	3	1	17	1	0	0	0	0	1	0	0	0	8506	1087	38	1	543	1	KRTAP10-10	21	46057875	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	180668	46057875	2072020	92	1190											
SGSM1	129049	broad.mit.edu	37	chr22	25263061	25263061	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accctccgtccgcttccagcGtctactgggactatgccatg	9	16	1	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr22:25263061G>A	uc003abg.2	+	10	1085	c.928G>A	c.(928-930)GTC>ATC	p.V310I	SGSM1_uc003abh.2_Missense_Mutation_p.V310I|SGSM1_uc010guu.1_Missense_Mutation_p.V310I|SGSM1_uc003abj.2_Missense_Mutation_p.V310I|SGSM1_uc003abi.1_Missense_Mutation_p.V285I	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	310	Required for interaction with RAP family members.					Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5						CGCTTCCAGCGTCTACTGGGA	0.617													A	25263061	A	A	25263061	3	1	17	1	0	0	0	0	1	0	0	0	14222	1159	40	1	966	1	SGSM1	22	25263061	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08		25263061	26041505	93	1191											
SYN3	8224	broad.mit.edu	37	chr22	32924868	32924868	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtgagggtcttacccaaggtCtgaggggggagggcgctgtg	20	7	2	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr22:32924868C>T	uc003amx.2	-	10	1382	c.1223G>A	c.(1222-1224)AGA>AAA	p.R408K	SYN3_uc003amy.2_Missense_Mutation_p.R408K|SYN3_uc003amz.2_Missense_Mutation_p.R407K|SYN3_uc011amc.1_Missense_Mutation_p.R42K	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	408	J; Pro-rich linker.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						TACCCAAGGTCTGAGGGGGGA	0.572											OREG0026488	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	32924868	T	T	32924868	3	4	17	1	0	0	0	0	1	0	0	0	15439	913	32	3	535	3	SYN3	22	32924868	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	7661807	32924868	18379698	94	1192											
CELSR1	9620	broad.mit.edu	37	chr22	46860064	46860064	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggacgttgaagacgaagacGtcgtccttggtggtggacag	16	7	0	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chr22:46860064G>A	uc003bhw.1	-	2	3723	c.3723C>T	c.(3721-3723)GAC>GAT	p.D1241D		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1241	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGACGAAGACGTCGTCCTTGG	0.642													A	46860064	A	A	46860064	2	1	17	1	0	0	0	0	0	0	0	1	3221	1136	40	1		1	CELSR1	22	46860064	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	13935196	46860064	4444502	95	1193											
CDKL5	6792	broad.mit.edu	37	chrX	18664128	18664128	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttctccccactaactagaCggtggatgtgatggcagaag	12	9	1	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chrX:18664128C>T	uc004cym.2	+	19	2968	c.2715C>T	c.(2713-2715)GAC>GAT	p.D905D	CDKL5_uc004cyn.2_Silent_p.D905D|RS1_uc004cyo.2_Intron	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	905					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding	p.D905D(1)		ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					actaactagacggtggatgtg	0													T	18664128	T	T	18664128	2	4	17	1	0	0	0	0	0	0	0	1	3157	550	19	1		1	CDKL5	23	18664128	Silent	SNP	C	TCGA-06-0137-01A-01D-1490-08		18664128	136606432	96	1194											
KIF4A	24137	broad.mit.edu	37	chrX	69510643	69510643	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cagtagcgccactcataaaaGgtgtatttaaaggtaaggcg	11	7	1	0			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chrX:69510643G>T	uc004dyg.2	+	3	350	c.223G>T	c.(223-225)GGT>TGT	p.G75C	KIF4A_uc010nkw.2_Missense_Mutation_p.G75C|PDZD11_uc004dyd.1_5'Flank|PDZD11_uc004dye.1_5'Flank|KIF4A_uc004dyf.1_Missense_Mutation_p.G75C	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	75	Kinesin-motor.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						ACTCATAAAAGGTGTATTTAA	0.289													T	69510643	T	T	69510643	3	4	17	1	0	0	0	0	1	0	0	0	8303	1000	35	5	229	5	KIF4A	23	69510643	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	50846515	69510643	85759917	97	1195											
DIAPH2	1730	broad.mit.edu	37	chrX	96684727	96684727	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attcagagaccgtcgaaagcGgattccaaggaatccaggta	11	9	1	1			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chrX:96684727G>A	uc004efu.3	+	26	3620	c.3224G>A	c.(3223-3225)CGG>CAG	p.R1075Q	DIAPH2_uc004eft.3_Missense_Mutation_p.R1075Q	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	1075	Arg/Lys-rich (basic).|DAD.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						CGTCGAAAGCGGATTCCAAGG	0.408													A	96684727	A	A	96684727	3	1	17	1	0	0	0	0	1	0	0	0	4519	1116	39	2	3326	2	DIAPH2	23	96684727	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	27174084	96684727	58585833	98	1196											
ALG13	79868	broad.mit.edu	37	chrX	110925413	110925413	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcaaattggtagaggaacGgtggtacctgaacccttcag	12	9	1	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chrX:110925413G>A	uc011msy.1	+	2	169	c.135G>A	c.(133-135)ACG>ACA	p.T45T	ALG13_uc004epi.1_Silent_p.T45T|ALG13_uc011msw.1_5'UTR|ALG13_uc011msx.1_Intron|ALG13_uc011msz.1_5'UTR|ALG13_uc011mta.1_Intron|ALG13_uc011mtb.1_5'UTR			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	45					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						GTAGAGGAACGGTGGTACCTG	0.413													A	110925413	A	A	110925413	2	1	17	1	0	0	0	0	0	0	0	1	515	1103	39	2		2	ALG13	23	110925413	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	14240686	110925413	44345147	99	1197											
ODZ1	10178	broad.mit.edu	37	chrX	123554390	123554390	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccattgctgctggtaatcgCgcccaagtcaccttcagaat	9	13	2	1	rs148440423	byFrequency	TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chrX:123554390C>T	uc004euj.2	-	24	4796	c.4732G>A	c.(4732-4734)GCG>ACG	p.A1578T	ODZ1_uc011muj.1_Missense_Mutation_p.A1584T|ODZ1_uc010nqy.2_Missense_Mutation_p.A1585T	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1578	YD 2.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CTGGTAATCGCGCCCAAGTCA	0.498													T	123554390	T	T	123554390	3	4	17	1	0	0	0	0	1	0	0	0	10834	768	27	1	3477	1	ODZ1	23	123554390	Missense_Mutation	SNP	C	TCGA-06-0137-01A-01D-1490-08	12628977	123554390	31716170	100	1198											
SPANXN2	494119	broad.mit.edu	37	chrX	142795381	142795381	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagatgagtccaggtcttcGtcctcctgtgaagatccttc	9	12	2	4			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chrX:142795381G>A	uc004fbz.2	-	2	1051	c.297C>T	c.(295-297)GAC>GAT	p.D99D		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	99										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGGTCTTCGTCCTCCTGTG	0.527													A	142795381	A	A	142795381	2	1	17	1	0	0	0	0	0	0	0	1	14991	1136	40	1		1	SPANXN2	23	142795381	Silent	SNP	G	TCGA-06-0137-01A-01D-1490-08	19240991	142795381	12475179	101	1199											
MAGEA1	4100	broad.mit.edu	37	chrX	152482500	152482500	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagacctaggcaggtgacaaGgacataggagtggccggtgg	18	7	0	2			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chrX:152482500G>A	uc004fhf.2	-	3	731	c.511C>T	c.(511-513)CTT>TTT	p.L171F		NM_004988	NP_004979	P43355	MAGA1_HUMAN	melanoma antigen family A, 1	171	MAGE.					cytoplasm|plasma membrane		p.L171F(1)		central_nervous_system(7)|ovary(1)|lung(1)|breast(1)	10	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGGTGACAAGGACATAGGAG	0.517													A	152482500	A	A	152482500	3	1	17	1	0	0	0	0	1	0	0	0	9163	1000	35	3	422	3	MAGEA1	23	152482500	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	9687119	152482500	2788060	102	1200											
RPL10	6134	broad.mit.edu	37	chrX	153631649	153631649	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagacctccagaaacacatcGtagagggcgttcagctcctt	10	12	1	3			TCGA-06-0137-01A-01D-1490-08	TCGA-06-0137-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	37c11dfc-c37c-4cb6-bd81-9e0a7789b0f1	6d9e2e37-9db9-471e-a35d-4269e8dc7746	g.chrX:153631649G>A	uc004fkr.1	+	3	348	c.313G>A	c.(313-315)GTA>ATA	p.V105I	RPL10_uc004fkq.1_RNA|DNASE1L1_uc004fks.1_Silent_p.Y162Y|DNASE1L1_uc004fkt.1_Silent_p.Y162Y|DNASE1L1_uc004fku.1_Silent_p.Y162Y|DNASE1L1_uc004fkv.1_Silent_p.Y162Y|DNASE1L1_uc004fkw.1_Silent_p.Y162Y	NM_006013	NP_006004	P27635	RL10_HUMAN	ribosomal protein L10	Error:Variant_position_missing_in_P27635_after_alignment					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GAAACACATCGTAGAGGGCGT	0.622													A	153631649	A	A	153631649	3	1	17	1	0	0	0	0	1	0	0	0	13554	1140	40	1		1	RPL10	23	153631649	Missense_Mutation	SNP	G	TCGA-06-0137-01A-01D-1490-08	1149149	153631649	1638911	103	1201											
WDR65	149465	broad.mit.edu	37	chr1	43651007	43651007	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggaagaaaaggatttttacCgtgagagcagagaaatcagg	13	4	1	3			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr1:43651007C>A	uc001cip.1	+	5	1070	c.949C>A	c.(949-951)CGT>AGT	p.R317S	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Missense_Mutation_p.R306S|WDR65_uc001ciq.1_Missense_Mutation_p.R317S	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	317										skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGATTTTTACCGTGAGAGCAG	0.473													A	43651007	A	A	43651007	3	1	18	1	0	0	0	0	1	0	0	0	17313	652	23	5	963	5	WDR65	1	43651007	Missense_Mutation	SNP	C	TCGA-06-0139-01A-01D-1490-08		43651007	205599614	1	1202											
PCDHB3	56132	broad.mit.edu	37	chr5	140480851	140480851	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgatcgggaggagcagccGgaactcagcttaacgctcac	12	13	2	0			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr5:140480851G>A	uc003lio.2	+	1	618	c.618G>A	c.(616-618)CCG>CCA	p.P206P	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	206	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGAGCAGCCGGAACTCAGCT	0.567													A	140480851	A	A	140480851	2	1	18	1	0	0	0	0	0	0	0	1	11543	1103	39	2		2	PCDHB3	5	140480851	Silent	SNP	G	TCGA-06-0139-01A-01D-1490-08		140480851	40434409	2	1203											
DIAPH1	1729	broad.mit.edu	37	chr5	140960406	140960406	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggatccatggctctgaccagCagtaggattccttcttctgt	10	11	3	1			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr5:140960406C>A	uc003llb.3	-	8	870	c.729G>T	c.(727-729)CTG>CTT	p.L243L	DIAPH1_uc003llc.3_Silent_p.L234L	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	243	GBD/FH3.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTGACCAGCAGTAGGATTC	0.473													A	140960406	A	A	140960406	2	1	18	1	0	0	0	0	0	0	0	1	4518	697	25	5		5	DIAPH1	5	140960406	Silent	SNP	C	TCGA-06-0139-01A-01D-1490-08	479555	140960406	39954854	3	1204											
PRSS55	203074	broad.mit.edu	37	chr8	10387101	10387101	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcggaggtgggtgagtttcCgtggcaggtgagtattcagg	20	5	1	2			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr8:10387101C>T	uc003wta.2	+	2	254	c.239C>T	c.(238-240)CCG>CTG	p.P80L	uc010lru.2_Intron|PRSS55_uc003wtb.2_RNA	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	80	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						GGTGAGTTTCCGTGGCAGGTG	0.512													T	10387101	T	T	10387101	3	4	18	1	0	0	0	0	1	0	0	0	12634	652	23	2	245	2	PRSS55	8	10387101	Missense_Mutation	SNP	C	TCGA-06-0139-01A-01D-1490-08		10387101	135976921	4	1205											
CYP7A1	1581	broad.mit.edu	37	chr8	59409488	59409488	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtgctttctgtgtgtcccGccttgtaagatctctgccaa	9	11	2	1			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr8:59409488G>A	uc003xtm.3	-	3	646	c.583C>T	c.(583-585)CGG>TGG	p.R195W		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	195					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TGTGTGTCCCGCCTTGTAAGA	0.453									Neonatal_Giant_Cell_Hepatitis				A	59409488	A	A	59409488	3	1	18	1	0	0	0	0	1	0	0	0	4196	1086	38	1	947	1	CYP7A1	8	59409488	Missense_Mutation	SNP	G	TCGA-06-0139-01A-01D-1490-08	49022387	59409488	86954534	5	1206											
PSAT1	29968	broad.mit.edu	37	chr9	80921319	80921319	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cggtgcatggtgtggagtttGactttatacccgatgtcaag	13	7	1	1			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr9:80921319G>A	uc004ala.2	+	5	555	c.487G>A	c.(487-489)GAC>AAC	p.D163N	PSAT1_uc004alb.2_Missense_Mutation_p.D163N	NM_058179	NP_478059	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1 isoform 1	163					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	TGTGGAGTTTGACTTTATACC	0.463													A	80921319	A	A	80921319	3	1	18	1	0	0	0	0	1	0	0	0	12644	1290	45	3	505	3	PSAT1	9	80921319	Missense_Mutation	SNP	G	TCGA-06-0139-01A-01D-1490-08		80921319	60292112	6	1207			1	7		2	2	25	G		7.752717e-06
PSAT1	29968	broad.mit.edu	37	chr9	80921343	80921343	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttatacccgatgtcaagggaGcagtactggtttgtgacatg	12	7	1	1	rs115263053	by1000genomes	TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr9:80921343G>A	uc004ala.2	+	5	579	c.511G>A	c.(511-513)GCA>ACA	p.A171T	PSAT1_uc004alb.2_Missense_Mutation_p.A171T	NM_058179	NP_478059	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1 isoform 1	171					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	TGTCAAGGGAGCAGTACTGGT	0.498													A	80921343	A	A	80921343	3	1	18	1	0	0	0	0	1	0	0	0	12644	971	34	3	529	3	PSAT1	9	80921343	Missense_Mutation	SNP	G	TCGA-06-0139-01A-01D-1490-08	24	80921343	60292088	7	1208			1	7		2	2	25	G		7.752717e-06
OR4F6	390648	broad.mit.edu	37	chr15	102346736	102346736	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacatcttgataaattccttGccatctttgatgcagttatc	5	10	2	2			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr15:102346736G>A	uc010utr.1	+	1	814	c.814G>A	c.(814-816)GCC>ACC	p.A272T		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	272	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TAAATTCCTTGCCATCTTTGA	0.378													A	102346736	A	A	102346736	3	1	18	1	0	0	0	0	1	0	0	0	11066	1319	46	3	816	3	OR4F6	15	102346736	Missense_Mutation	SNP	G	TCGA-06-0139-01A-01D-1490-08		102346736	184656	8	1209											
TANC2	26115	broad.mit.edu	37	chr17	61391934	61391934	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtgggaaacattggattcGgcaaaactgccatcatctcc	9	10	2	0			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr17:61391934G>A	uc002jal.3	+	8	1146	c.1123G>A	c.(1123-1125)GGC>AGC	p.G375S	TANC2_uc010wpe.1_Missense_Mutation_p.G285S	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	375							binding			ovary(2)	2						CATTGGATTCGGCAAAACTGC	0.507													A	61391934	A	A	61391934	3	1	18	1	0	0	0	0	1	0	0	0	15542	1116	39	2	1153	2	TANC2	17	61391934	Missense_Mutation	SNP	G	TCGA-06-0139-01A-01D-1490-08		61391934	19803276	9	1210											
EXOC7	23265	broad.mit.edu	37	chr17	74094004	74094004	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcgtcaccactgatcagatcCaagatgagcacgggcgagac	11	12	2	5			TCGA-06-0139-01A-01D-1490-08	TCGA-06-0139-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	c84ff17d-436d-49c1-aef2-b998ffe4a693	c739fdc7-b0df-4096-a7dd-50f519c9160f	g.chr17:74094004C>A	uc002jqs.2	-	5	608	c.513G>T	c.(511-513)TTG>TTT	p.L171F	EXOC7_uc010dgv.1_Missense_Mutation_p.L118F|EXOC7_uc002jqq.2_Missense_Mutation_p.L171F|EXOC7_uc010wsw.1_Missense_Mutation_p.L171F|EXOC7_uc010wsx.1_Missense_Mutation_p.L171F|EXOC7_uc002jqr.2_Missense_Mutation_p.L171F|EXOC7_uc010wsv.1_Missense_Mutation_p.L130F|EXOC7_uc002jqu.2_Missense_Mutation_p.L171F	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	171					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			TGATCAGATCCAAGATGAGCA	0.602													A	74094004	A	A	74094004	3	1	18	1	0	0	0	0	1	0	0	0	5310	593	21	5	1758	5	EXOC7	17	74094004	Missense_Mutation	SNP	C	TCGA-06-0139-01A-01D-1490-08	12702070	74094004	7101206	10	1211											
ABCA4	24	broad.mit.edu	37	chr1	94463458	94463458	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gactgagtactcctcgatgaGcaggctgtccttgtgggaga	14	9	0	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr1:94463458G>A	uc001dqh.2	-	48	6792	c.6688C>T	c.(6688-6690)CTC>TTC	p.L2230F		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	2230	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCCTCGATGAGCAGGCTGTCC	0.592													A	94463458	A	A	94463458	3	1	19	1	0	0	0	0	1	0	0	0	34	971	34	3	145	3	ABCA4	1	94463458	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08		94463458	154787163	1	1212											
OPTC	26254	broad.mit.edu	37	chr1	203472741	203472741	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgaggagcacaaacacaccCgcaggcagctggaagacatc	11	14	0	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr1:203472741C>T	uc001gzu.1	+	7	1008	c.892C>T	c.(892-894)CGC>TGC	p.R298C		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	298						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			CAAACACACCCGCAGGCAGCT	0.587													T	203472741	T	T	203472741	3	4	19	1	0	0	0	0	1	0	0	0	10888	652	23	2	914	2	OPTC	1	203472741	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08	109009283	203472741	45777880	2	1213											
PIGR	5284	broad.mit.edu	37	chr1	207109154	207109154	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccacagtggggctgcggggaAtcgtggactctggaagcaca	16	10	1	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr1:207109154A>T	uc001hez.2	-	5	1239	c.1055T>A	c.(1054-1056)ATT>AAT	p.I352N	PIGR_uc009xbz.2_Missense_Mutation_p.I352N	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	352	Ig-like V-type 3.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GCTGCGGGGAATCGTGGACTC	0.602											OREG0014186	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	207109154	T	T	207109154	3	4	19	1	0	0	0	0	1	0	0	0	11897	101	4	5	1267	5	PIGR	1	207109154	Missense_Mutation	SNP	A	TCGA-06-0140-01A-01D-1490-08	3636413	207109154	42141467	3	1214											
NBAS	51594	broad.mit.edu	37	chr2	15493765	15493765	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaaagccatgagctcttgaCgagtggccaagtcctggtaa	11	10	1	2	rs140188229		TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr2:15493765C>T	uc002rcc.1	-	34	4027	c.4001G>A	c.(4000-4002)CGT>CAT	p.R1334H	NBAS_uc010exl.1_Missense_Mutation_p.R406H|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1334										ovary(2)|liver(1)|skin(1)	4						GAGCTCTTGACGAGTGGCCAA	0.453													T	15493765	T	T	15493765	3	4	19	1	0	0	0	0	1	0	0	0	10186	536	19	1	3190	1	NBAS	2	15493765	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08		15493765	227705608	4	1215											
CYP26B1	56603	broad.mit.edu	37	chr2	72360330	72360330	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgagcccgcagctcatccCgcagcttctccagcacagtg	9	17	2	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr2:72360330C>T	uc002sih.1	-	5	968	c.968G>A	c.(967-969)CGG>CAG	p.R323Q	CYP26B1_uc010yra.1_Missense_Mutation_p.R306Q|CYP26B1_uc010yrb.1_Missense_Mutation_p.R248Q	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	323					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						CAGCTCATCCCGCAGCTTCTC	0.657													T	72360330	T	T	72360330	3	4	19	1	0	0	0	0	1	0	0	0	4156	652	23	2	578	2	CYP26B1	2	72360330	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08	56866565	72360330	170839043	5	1216											
ST6GAL2	84620	broad.mit.edu	37	chr2	107460088	107460088	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actttgagattttctccccaCctgggatgaaaaaaactctt	6	10	2	2			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr2:107460088C>T	uc002tdq.2	-	2	465	c.346G>A	c.(346-348)GTG>ATG	p.V116M	ST6GAL2_uc002tdr.2_Missense_Mutation_p.V116M|ST6GAL2_uc002tds.3_Missense_Mutation_p.V116M	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	116	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						TTTCTCCCCACCTGGGATGAA	0.547													T	107460088	T	T	107460088	3	4	19	1	0	0	0	0	1	0	0	0	15221	507	18	3	1350	3	ST6GAL2	2	107460088	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08	35099758	107460088	135739285	6	1217											
ACTR3	10096	broad.mit.edu	37	chr2	114691915	114691915	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaggagaacggacgttgacCggtacggtaatagacagtgg	16	6	0	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr2:114691915C>T	uc002tkx.1	+	6	812	c.492C>T	c.(490-492)ACC>ACT	p.T164T	ACTR3_uc010yyc.1_Silent_p.T102T|ACTR3_uc010yyd.1_Silent_p.T113T	NM_005721	NP_005712	P61158	ARP3_HUMAN	ARP3 actin-related protein 3 homolog	164					cellular component movement|cilium morphogenesis	Arp2/3 protein complex	actin binding|ATP binding			skin(1)	1						GGACGTTGACCGGTACGGTAA	0.383													T	114691915	T	T	114691915	2	4	19	1	0	0	0	0	0	0	0	1	212	639	23	2		2	ACTR3	2	114691915	Silent	SNP	C	TCGA-06-0140-01A-01D-1490-08	7231827	114691915	128507458	7	1218											
PRPF40A	55660	broad.mit.edu	37	chr2	153515685	153515685	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tttctttgaatggctatcatCatcatctgaatctgacccct	5	11	6	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr2:153515685C>T	uc002tyh.3	-	23	2450	c.2428G>A	c.(2428-2430)GAT>AAT	p.D810N	PRPF40A_uc002tyg.3_Missense_Mutation_p.D266N|PRPF40A_uc010zcd.1_Missense_Mutation_p.D761N	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	837					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						TGGCTATCATCATCATCTGAA	0.343													T	153515685	T	T	153515685	3	4	19	1	0	0	0	0	1	0	0	0	12571	826	29	3	380	3	PRPF40A	2	153515685	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08	38823770	153515685	89683688	8	1219											
STK11IP	114790	broad.mit.edu	37	chr2	220476376	220476376	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaccacgtggttctcctcGctgtgtctcggggaaccccc	12	15	2	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr2:220476376G>A	uc002vml.2	+	18	2231	c.2188G>A	c.(2188-2190)GCT>ACT	p.A730T		NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	730					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTTCTCCTCGCTGTGTCTCG	0.627													A	220476376	A	A	220476376	3	1	19	1	0	0	0	0	1	0	0	0	15287	1087	38	1	2258	1	STK11IP	2	220476376	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	66960691	220476376	22722997	9	1220											
SCG2	7857	broad.mit.edu	37	chr2	224462380	224462380	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatggcctgctcaatttgttCctcttcctgcaggtcatctt	8	12	4	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr2:224462380C>T	uc002vnm.2	-	2	1754	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	541					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCAATTTGTTCCTCTTCCTGC	0.507													T	224462380	T	T	224462380	3	4	19	1	0	0	0	0	1	0	0	0	13891	864	30	3	236	3	SCG2	2	224462380	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08	3986004	224462380	18736993	10	1221											
MLPH	79083	broad.mit.edu	37	chr2	238449110	238449110	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcgtccgaggaggaggaagcCaaggacgaaaaggcagagcc	16	9	0	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr2:238449110C>A	uc002vwt.2	+	10	1451	c.1224C>A	c.(1222-1224)GCC>GCA	p.A408A	MLPH_uc002vws.2_Silent_p.A265A|MLPH_uc010fyt.1_Silent_p.A380A|MLPH_uc002vwu.2_Silent_p.A380A|MLPH_uc002vwv.2_Silent_p.A340A|MLPH_uc002vww.2_Silent_p.A356A|MLPH_uc002vwx.2_Silent_p.A264A|MLPH_uc010fyu.2_Silent_p.A160A	NM_024101	NP_077006	Q9BV36	MELPH_HUMAN	melanophilin isoform 1	408	Potential.						metal ion binding			ovary(1)	1		Breast(86;0.000381)|Renal(207;0.000966)|Ovarian(221;0.0695)|all_hematologic(139;0.095)|all_lung(227;0.17)|Melanoma(123;0.203)		Epithelial(121;1.17e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.02e-10)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.15e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000439)|Lung(119;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0316)		AGGAGGAAGCCAAGGACGAAA	0.627													A	238449110	A	A	238449110	2	1	19	1	0	0	0	0	0	0	0	1	9633	581	21	5		5	MLPH	2	238449110	Silent	SNP	C	TCGA-06-0140-01A-01D-1490-08	13986730	238449110	4750263	11	1222											
PLA1A	51365	broad.mit.edu	37	chr3	119316815	119316815	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggggggcctcattttgtggCtcagcgttggaagttcaggt	16	7	3	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr3:119316815C>G	uc003ecu.2	+	1	94	c.55C>G	c.(55-57)CTC>GTC	p.L19V	PLA1A_uc003ecv.2_Missense_Mutation_p.L19V|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_5'UTR	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	19					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CATTTTGTGGCTCAGCGTTGG	0.507													G	119316815	G	G	119316815	3	3	19	1	0	0	0	0	1	0	0	0	11988	797	28	5	57	5	PLA1A	3	119316815	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08		119316815	78705615	12	1223											
MRPL3	11222	broad.mit.edu	37	chr3	131190114	131190114	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcatgacaccttgaaaaccTttaccaatactgaacaaaac	3	11	1	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr3:131190114T>C	uc003eoh.2	-	7	803	c.639A>G	c.(637-639)AAA>AAG	p.K213K	MRPL3_uc011blo.1_Silent_p.K108K|MRPL3_uc011blp.1_Silent_p.K240K	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	213					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						CTTGAAAACCTTTACCAATAC	0.408													C	131190114	C	C	131190114	2	2	19	1	0	0	0	0	0	0	0	1	9793	1606	56	4		4	MRPL3	3	131190114	Silent	SNP	T	TCGA-06-0140-01A-01D-1490-08	11873299	131190114	66832316	13	1224											
RASSF6	166824	broad.mit.edu	37	chr4	74442417	74442417	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaggagcctctgcagtagCggaatgtctgtcttctttag	12	8	4	0	rs147932445	byFrequency	TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr4:74442417C>T	uc003hhd.1	-	9	972	c.849G>A	c.(847-849)CCG>CCA	p.P283P	RASSF6_uc003hhc.1_Silent_p.P251P|RASSF6_uc010iik.1_Silent_p.P217P|RASSF6_uc010iil.1_Silent_p.P239P	NM_201431	NP_958834	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family 6	283	Ras-associating.				apoptosis|signal transduction		protein binding			pancreas(2)	2	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TCTGCAGTAGCGGAATGTCTG	0.403													T	74442417	T	T	74442417	2	4	19	1	0	0	0	0	0	0	0	1	13090	755	27	1		1	RASSF6	4	74442417	Silent	SNP	C	TCGA-06-0140-01A-01D-1490-08		74442417	116711859	14	1225											
DSPP	1834	broad.mit.edu	37	chr4	88534401	88534401	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accatagagaaagcaaacgcGtagaaaatagaatcaccaaa	7	8	1	3	rs61738515	by1000genomes	TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr4:88534401G>A	uc003hqu.2	+	4	1183	c.1063G>A	c.(1063-1065)GTA>ATA	p.V355I		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	355					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		AAGCAAACGCGTAGAAAATAG	0.418													A	88534401	A	A	88534401	3	1	19	1	0	0	0	0	1	0	0	0	4782	1145	40	1	1073	1	DSPP	4	88534401	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	14091984	88534401	102619875	15	1226											
GYPE	2996	broad.mit.edu	37	chr4	144826671	144826671	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccatacatcctgagatcaCgagctggctcctgaagttag	9	11	1	2			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr4:144826671C>T	uc003ijj.2	-	1	46	c.-10G>A	c.(-12--8)TCGTG>TCATG		GYPE_uc010ion.2_RNA|GYPE_uc003ijk.3_Translation_Start_Site	NM_198682	NP_941391	P15421	GLPE_HUMAN	glycophorin E precursor							integral to plasma membrane					0	all_hematologic(180;0.158)					CCTGAGATCACGAGCTGGCTC	0.398													T	144826671	T	T	144826671	1	4	19	1	0	0	0	0	0	0	0	0	6911	551	19	1		1	GYPE	4	144826671	Translation_Start_Site	SNP	C	TCGA-06-0140-01A-01D-1490-08	56292270	144826671	46327605	16	1227											
TRIM2	23321	broad.mit.edu	37	chr4	154215581	154215581	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctccagaagactttaaatGtgcgcaagagtgtgctgctt	11	8	0	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr4:154215581G>A	uc003ing.2	+	5	850	c.649G>A	c.(649-651)GTG>ATG	p.V217M	TRIM2_uc003inh.2_Missense_Mutation_p.V244M	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	217						cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		GACTTTAAATGTGCGCAAGAG	0.418													A	154215581	A	A	154215581	3	1	19	1	0	0	0	0	1	0	0	0	16491	1377	48	3	748	3	TRIM2	4	154215581	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	9388910	154215581	36938695	17	1228											
IL7R	3575	broad.mit.edu	37	chr5	35876389	35876389	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctagactgcagggagagtgGcaagaatgggcctcatgtgt	15	8	1	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr5:35876389G>A	uc003jjs.2	+	8	1270	c.1181G>A	c.(1180-1182)GGC>GAC	p.G394D	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	394	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AGGGAGAGTGGCAAGAATGGG	0.537													A	35876389	A	A	35876389	3	1	19	1	0	0	0	0	1	0	0	0	7705	1203	42	3	1211	3	IL7R	5	35876389	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08		35876389	145038871	18	1229											
UTP15	84135	broad.mit.edu	37	chr5	72864347	72864347	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacaagatggtagattgcttGtggctggcagtgaagatggt	16	4	0	4			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr5:72864347G>A	uc003kcw.1	+	4	509	c.286G>A	c.(286-288)GTG>ATG	p.V96M	UTP15_uc011cso.1_Missense_Mutation_p.V77M|UTP15_uc011csp.1_Translation_Start_Site|UTP15_uc010ize.1_Missense_Mutation_p.V96M|ANKRA2_uc003kcu.1_5'Flank|ANKRA2_uc003kcv.2_5'Flank	NM_032175	NP_115551	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein,	96	WD 2.				rRNA processing	cytoplasm|nucleolus					0		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		TAGATTGCTTGTGGCTGGCAG	0.428													A	72864347	A	A	72864347	3	1	19	1	0	0	0	0	1	0	0	0	17094	1377	48	3	296	3	UTP15	5	72864347	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	36987958	72864347	108050913	19	1230											
GRIA1	2890	broad.mit.edu	37	chr5	153190767	153190767	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagttcagggatgcccttGggagccacgggattgtaact	13	10	1	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr5:153190767G>A	uc003lva.3	+	16	3068	c.2703G>A	c.(2701-2703)TTG>TTA	p.L901L	GRIA1_uc003luy.3_Silent_p.L901L|GRIA1_uc003luz.3_Silent_p.L806L|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Silent_p.L821L|GRIA1_uc011dcx.1_Silent_p.L832L|GRIA1_uc011dcy.1_Silent_p.L911L|GRIA1_uc011dcz.1_Silent_p.L911L	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	901	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGATGCCCTTGGGAGCCACGG	0.592													A	153190767	A	A	153190767	2	1	19	1	0	0	0	0	0	0	0	1	6767	1339	47	3		3	GRIA1	5	153190767	Silent	SNP	G	TCGA-06-0140-01A-01D-1490-08	80326420	153190767	27724493	20	1231											
IRF4	3662	broad.mit.edu	37	chr6	398928	398928	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtctgccgaagccttggcGttctcaggtgagtgcagggt	16	9	2	1	rs144395675		TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr6:398928G>A	uc003msz.3	+	6	851	c.738G>A	c.(736-738)GCG>GCA	p.A246A	IRF4_uc010jne.1_Silent_p.A246A|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Silent_p.A245A|IRF4_uc003mtc.1_Silent_p.A76A	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	246					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		AAGCCTTGGCGTTCTCAGGTG	0.592			T	IGH@	MM 								A	398928	A	A	398928	2	1	19	1	0	0	0	0	0	0	0	1	7832	1132	40	1		1	IRF4	6	398928	Silent	SNP	G	TCGA-06-0140-01A-01D-1490-08		398928	170716139	21	1232											
ECT2L	345930	broad.mit.edu	37	chr6	139208055	139208055	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagagaatcatctggggatGccctgtatgtattcttagga	11	7	3	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr6:139208055G>A	uc003qif.1	+	17	2424	c.2321G>A	c.(2320-2322)TGC>TAC	p.C774Y	ECT2L_uc011edq.1_Missense_Mutation_p.C628Y	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	774					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						ATCTGGGGATGCCCTGTATGT	0.373													A	139208055	A	A	139208055	3	1	19	1	0	0	0	0	1	0	0	0	4902	1319	46	3	2387	3	ECT2L	6	139208055	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	138809127	139208055	31907012	22	1233											
MAD1L1	8379	broad.mit.edu	37	chr7	1855850	1855850	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtagctgcatcttggaaccCgaggggctggtggcctgcgg	17	10	1	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr7:1855850C>T	uc003slh.1	-	19	2279	c.2013G>A	c.(2011-2013)TCG>TCA	p.S671S	MAD1L1_uc003sle.1_Silent_p.S400S|MAD1L1_uc003slf.1_Silent_p.S671S|MAD1L1_uc003slg.1_Silent_p.S671S|MAD1L1_uc010ksh.1_Silent_p.S671S|MAD1L1_uc003sli.1_Silent_p.S579S|MAD1L1_uc003sld.1_Silent_p.S127S	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	671					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TCTTGGAACCCGAGGGGCTGG	0.642													T	1855850	T	T	1855850	2	4	19	1	0	0	0	0	0	0	0	1	9147	639	23	2		2	MAD1L1	7	1855850	Silent	SNP	C	TCGA-06-0140-01A-01D-1490-08		1855850	157282813	23	1234											
ELN	2006	broad.mit.edu	37	chr7	73457353	73457353	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cccaggagttggtggcttagGagtgtctgcaggtacgatgg	17	7	1	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr7:73457353G>A	uc003tzw.2	+	7	456	c.365G>A	c.(364-366)GGA>GAA	p.G122E	RFC2_uc011kfa.1_Intron|ELN_uc003tzm.1_Intron|ELN_uc011kfe.1_Missense_Mutation_p.G91E|ELN_uc003tzn.2_Missense_Mutation_p.G122E|ELN_uc003tzz.2_Missense_Mutation_p.G110E|ELN_uc003tzo.2_Missense_Mutation_p.G122E|ELN_uc003tzp.2_Missense_Mutation_p.G112E|ELN_uc003tzq.2_Intron|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Missense_Mutation_p.G122E|ELN_uc003tzt.2_Missense_Mutation_p.G122E|ELN_uc003tzu.2_Missense_Mutation_p.G122E|ELN_uc003tzv.2_Missense_Mutation_p.G112E|ELN_uc003tzx.2_Missense_Mutation_p.G112E|ELN_uc011kff.1_Missense_Mutation_p.G122E|ELN_uc003tzy.2_Missense_Mutation_p.G112E	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	122					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	GGTGGCTTAGGAGTGTCTGCA	0.627			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						A	73457353	A	A	73457353	3	1	19	1	0	0	0	0	1	0	0	0	5071	1174	41	3	391	3	ELN	7	73457353	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	71601503	73457353	85681310	24	1235											
GTF2IRD1	9569	broad.mit.edu	37	chr7	73922465	73922465	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaacggctgcggacccgacCgctggaactccgcgttcacc	11	18	1	0	rs139144176		TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr7:73922465C>T	uc003uaq.2	+	2	448	c.55C>T	c.(55-57)CGC>TGC	p.R19C	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.R19C|GTF2IRD1_uc003uap.2_Missense_Mutation_p.R19C|GTF2IRD1_uc003uar.1_Missense_Mutation_p.R19C	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	19						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						CGGACCCGACCGCTGGAACTC	0.642													T	73922465	T	T	73922465	3	4	19	1	0	0	0	0	1	0	0	0	6868	652	23	2	57	2	GTF2IRD1	7	73922465	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08	465112	73922465	85216198	25	1236											
NPTX2	4885	broad.mit.edu	37	chr7	98257925	98257925	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtggagacgtgtgaggagcGtctccttgacttgtagccgc	15	10	1	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr7:98257925G>A	uc003upl.2	+	5	1457	c.1280G>A	c.(1279-1281)CGT>CAT	p.R427H		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	427	Pentaxin.			R -> A (in Ref. 1; AAA68980/AAA92296).	synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			TGTGAGGAGCGTCTCCTTGAC	0.582													A	98257925	A	A	98257925	3	1	19	1	0	0	0	0	1	0	0	0	10603	1145	40	1	1298	1	NPTX2	7	98257925	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	24335460	98257925	60880738	26	1237											
AZGP1	563	broad.mit.edu	37	chr7	99564820	99564820	+	Frame_Shift_Del	DEL	T	-	-													ccgagtccagtgcacatcaaTtttccctgggtagaagtcgt							TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr7:99564820delT	uc003ush.2	-	4	747	c.703delA	c.(703-705)ATTfs	p.I235fs		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	235	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					TGCACATCAATTTTCCCTGGG	0.567													-	99564820	-	-	99564820	7	5	19	1	0	1	0	1	0	0	0	0	1239	1493	52	0	197	0	AZGP1	7	99564820	Frame_Shift_Del	DEL	T	TCGA-06-0140-01A-01D-1490-08	1306895	99564820	59573843	27	1238											
REPIN1	29803	broad.mit.edu	37	chr7	150068350	150068350	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgctggaacgtcgttgcaGgggccccctggccatgggcc	16	13	0	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr7:150068350G>A	uc010lpq.1	+	4	509	c.20G>A	c.(19-21)AGG>AAG	p.R7K	REPIN1_uc003whd.2_5'UTR|REPIN1_uc010lpr.1_Missense_Mutation_p.R64K|REPIN1_uc003whc.2_Missense_Mutation_p.R7K|REPIN1_uc003whe.2_Missense_Mutation_p.R7K	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	7					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CGTCGTTGCAGGGGCCCCCTG	0.647													A	150068350	A	A	150068350	3	1	19	1	0	0	0	0	1	0	0	0	13227	1000	35	3	197	3	REPIN1	7	150068350	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	50503530	150068350	9070313	28	1239											
C9orf96	169436	broad.mit.edu	37	chr9	136260823	136260823	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggagaagcagatcccggatGtggaaaccttcaggaatctt	12	8	2	2			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr9:136260823G>T	uc004cdk.2	+	9	860	c.799G>T	c.(799-801)GTG>TTG	p.V267L	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	267	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GATCCCGGATGTGGAAACCTT	0.552													T	136260823	T	T	136260823	3	4	19	1	0	0	0	0	1	0	0	0	2508	1377	48	5	833	5	C9orf96	9	136260823	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08		136260823	4952608	29	1240											
SLC18A2	6571	broad.mit.edu	37	chr10	119003545	119003545	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaatgctacagaaatccagaCggccaggccagtgcacactg	11	12	0	2	rs140529367		TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr10:119003545C>T	uc001ldd.1	+	3	216	c.185C>T	c.(184-186)ACG>ATG	p.T62M	SLC18A2_uc009xyy.1_Translation_Start_Site	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	62	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	GAAATCCAGACGGCCAGGCCA	0.493													T	119003545	T	T	119003545	3	4	19	1	0	0	0	0	1	0	0	0	14426	536	19	1	191	1	SLC18A2	10	119003545	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08		119003545	16531202	30	1241											
CLRN3	119467	broad.mit.edu	37	chr10	129682096	129682096	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accaggaacaggatagtcacCgaatgcagagttttttggga	12	7	1	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr10:129682096C>T	uc001lka.1	-	2	436	c.273G>A	c.(271-273)TCG>TCA	p.S91S	CLRN3_uc001ljz.1_Silent_p.S23S	NM_152311	NP_689524	Q8NCR9	CLRN3_HUMAN	clarin 3	91						integral to membrane				skin(1)	1		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				GGATAGTCACCGAATGCAGAG	0.448													T	129682096	T	T	129682096	2	4	19	1	0	0	0	0	0	0	0	1	3559	639	23	2		2	CLRN3	10	129682096	Silent	SNP	C	TCGA-06-0140-01A-01D-1490-08	10678551	129682096	5852651	31	1242											
OR51G1	79324	broad.mit.edu	37	chr11	4945520	4945520	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctagaccttggaagcccGtcaggaagaaagtggctctt	11	10	3	2			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr11:4945520G>A	uc010qyr.1	-	1	50	c.50C>T	c.(49-51)ACG>ATG	p.T17M		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGGAAGCCCGTCAGGAAGAA	0.458													A	4945520	A	A	4945520	3	1	19	1	0	0	0	0	1	0	0	0	11098	1145	40	1	917	1	OR51G1	11	4945520	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08		4945520	130060996	32	1243											
OR51A2	401667	broad.mit.edu	37	chr11	4976936	4976936	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caacatatgatgtgttgataAtggacatgattcattcatag	8	5	2	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr11:4976936A>G	uc010qyt.1	-	1	8	c.8T>C	c.(7-9)ATT>ACT	p.I3T		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTGTTGATAATGGACATGAT	0.428													G	4976936	G	G	4976936	3	3	19	1	0	0	0	0	1	0	0	0	11086	101	4	4	935	4	OR51A2	11	4976936	Missense_Mutation	SNP	A	TCGA-06-0140-01A-01D-1490-08	31416	4976936	130029580	33	1244											
MS4A7	58475	broad.mit.edu	37	chr11	60161321	60161321	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcaaaaagagttcttcacGgtcttggatataagtaactc	9	7	4	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr11:60161321G>A	uc001npe.2	+	7	855	c.710G>A	c.(709-711)CGG>CAG	p.R237Q	MS4A7_uc001npf.2_Missense_Mutation_p.R237Q|MS4A7_uc001npg.2_Missense_Mutation_p.R192Q|MS4A7_uc001nph.2_Missense_Mutation_p.R192Q|MS4A14_uc001npi.2_Intron	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	237	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						AGTTCTTCACGGTCTTGGATA	0.373													A	60161321	A	A	60161321	3	1	19	1	0	0	0	0	1	0	0	0	9866	1116	39	2	732	2	MS4A7	11	60161321	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	55184385	60161321	74845195	34	1245											
VWCE	220001	broad.mit.edu	37	chr11	61032003	61032003	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggaagcagggcagggtcgGcacaggcccgctggcaggga	19	11	0	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr11:61032003G>A	uc001nra.2	-	19	2465	c.2186C>T	c.(2185-2187)GCC>GTC	p.A729V	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	729	VWFC 6.					extracellular region	calcium ion binding			ovary(1)	1						GGCAGGGTCGGCACAGGCCCG	0.592													A	61032003	A	A	61032003	3	1	19	1	0	0	0	0	1	0	0	0	17242	1203	42	3	689	3	VWCE	11	61032003	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	870682	61032003	73974513	35	1246											
HTR3A	3359	broad.mit.edu	37	chr11	113857684	113857684	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctggttctggagagaatcGcctggctactttgcctgagg	13	10	1	2			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr11:113857684G>A	uc010rxb.1	+	7	1401	c.1168G>A	c.(1168-1170)GCC>ACC	p.A390T	HTR3A_uc010rxa.1_Missense_Mutation_p.A358T|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Missense_Mutation_p.A337T	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	352	Cytoplasmic (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GGAGAGAATCGCCTGGCTACT	0.587													A	113857684	A	A	113857684	3	1	19	1	0	0	0	0	1	0	0	0	7444	1087	38	1	1220	1	HTR3A	11	113857684	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	52825681	113857684	21148832	36	1247											
C12orf51	283450	broad.mit.edu	37	chr12	112721040	112721040	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	attaatgcttttggcagattCgccctcttttctcattagaa	6	9	2	2			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr12:112721040C>T	uc009zwc.2	-	2	238	c.220G>A	c.(220-222)GAA>AAA	p.E74K		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TTGGCAGATTCGCCCTCTTTT	0.433													T	112721040	T	T	112721040	3	4	19	1	0	0	0	0	1	0	0	0	1696	893	31	2	12042	2	C12orf51	12	112721040	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08		112721040	21130855	37	1248											
RB1	5925	broad.mit.edu	37	chr13	48951144	48951144	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatttgctaaagctgtgggaCagggttgtgtcgaaattgga	14	4	0	0	rs4151534		TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr13:48951144C>T	uc001vcb.2	+	13	1472	c.1306C>T	c.(1306-1308)CAG>TAG	p.Q436*	RB1_uc010act.1_Nonsense_Mutation_p.Q137*	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	436	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGCTGTGGGACAGGGTTGTGT	0.353		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	48951144	T	T	48951144	4	4	19	1	0	0	0	0	0	1	0	0	13098	479	17	3	1356	3	RB1	13	48951144	Nonsense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08		48951144	66218734	38	1249											
C14orf115	55237	broad.mit.edu	37	chr14	74825422	74825422	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggatgctggtgatggacatgAtcgctaccacgaagttcaag	13	8	1	2			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr14:74825422A>G	uc001xpw.3	+	2	2127	c.1936A>G	c.(1936-1938)ATC>GTC	p.I646V		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	646					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		GATGGACATGATCGCTACCAC	0.617													G	74825422	G	G	74825422	3	3	19	1	0	0	0	0	1	0	0	0	1740	333	12	4	1938	4	C14orf115	14	74825422	Missense_Mutation	SNP	A	TCGA-06-0140-01A-01D-1490-08		74825422	32524118	39	1250											
ATP10A	57194	broad.mit.edu	37	chr15	25925003	25925003	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccgagtccttcgggaggcGtccctgagcaaaggtctctt	12	13	1	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr15:25925003G>A	uc010ayu.2	-	21	4091	c.3985C>T	c.(3985-3987)CGC>TGC	p.R1329C		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1329	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TTCGGGAGGCGTCCCTGAGCA	0.607													A	25925003	A	A	25925003	3	1	19	1	0	0	0	0	1	0	0	0	1116	1145	40	1	518	1	ATP10A	15	25925003	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08		25925003	76606389	40	1251											
RASGRP1	10125	broad.mit.edu	37	chr15	38818585	38818585	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttgcaacagttggttacttcGacacaggtttccatctgcat	8	10	1	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr15:38818585G>A	uc001zke.3	-	3	419	c.241C>T	c.(241-243)CGA>TGA	p.R81*	RASGRP1_uc001zkd.3_Nonsense_Mutation_p.R81*	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	81	Ras exchanger motif region; required for transforming activity (By similarity).|N-terminal Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TGGTTACTTCGACACAGGTTT	0.458													A	38818585	A	A	38818585	4	1	19	1	0	0	0	0	0	1	0	0	13074	1066	37	2	2212	2	RASGRP1	15	38818585	Nonsense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	12893582	38818585	63712807	41	1252											
FAM86A	196483	broad.mit.edu	37	chr16	5143514	5143514	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagttctgagagaaagcaccGggcatatttgacggacggcg	15	8	1	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr16:5143514G>A	uc002cyo.2	-	3	260	c.211C>T	c.(211-213)CGG>TGG	p.R71W	FAM86A_uc002cyp.2_Missense_Mutation_p.R71W	NM_201400	NP_958802	Q96G04	FA86A_HUMAN	hypothetical protein LOC196483 isoform 1	71											0						AGAAAGCACCGGGCATATTTG	0.522													A	5143514	A	A	5143514	3	1	19	1	0	0	0	0	1	0	0	0	5643	1115	39	2	805	2	FAM86A	16	5143514	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08		5143514	85211239	42	1253											
DNAH3	55567	broad.mit.edu	37	chr16	20976074	20976074	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttttatgggatcccctaaCgtgtggctgagactgaagtc	11	8	0	2	rs149630157	byFrequency	TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr16:20976074C>T	uc010vbe.1	-	53	9132	c.9132G>A	c.(9130-9132)ACG>ACA	p.T3044T	DNAH3_uc010vbd.1_Silent_p.T479T	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3044					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GATCCCCTAACGTGTGGCTGA	0.498													T	20976074	T	T	20976074	2	4	19	1	0	0	0	0	0	0	0	1	4603	523	19	1		1	DNAH3	16	20976074	Silent	SNP	C	TCGA-06-0140-01A-01D-1490-08	15832560	20976074	69378679	43	1254											
KIFC3	3801	broad.mit.edu	37	chr16	57794781	57794781	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agccgacagcgacttgttgaTgtgctgcgcctcccgcaggc	13	14	0	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr16:57794781T>C	uc002emp.2	-	16	2286	c.2089A>G	c.(2089-2091)ATC>GTC	p.I697V	KIFC3_uc010vhw.1_Missense_Mutation_p.I595V|KIFC3_uc002emn.2_RNA|KIFC3_uc002emm.2_Missense_Mutation_p.I558V|KIFC3_uc010vhx.1_Missense_Mutation_p.I555V|KIFC3_uc010cdf.2_Missense_Mutation_p.I558V|KIFC3_uc002emo.3_Missense_Mutation_p.I558V|KIFC3_uc010vhy.1_Missense_Mutation_p.I639V|KIFC3_uc002emq.2_Missense_Mutation_p.I697V|KIFC3_uc010vhz.1_Missense_Mutation_p.I719V	NM_005550	NP_005541	Q9BVG8	KIFC3_HUMAN	kinesin family member C3 isoform 1	697	Kinesin-motor.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			central_nervous_system(2)|ovary(1)	3		all_neural(199;0.224)				GACTTGTTGATGTGCTGCGCC	0.682													C	57794781	C	C	57794781	3	2	19	1	0	0	0	0	1	0	0	0	8314	1464	51	4	437	4	KIFC3	16	57794781	Missense_Mutation	SNP	T	TCGA-06-0140-01A-01D-1490-08	36818707	57794781	32559972	44	1255											
CHST6	4166	broad.mit.edu	37	chr16	75513386	75513386	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaggtcggacaggttgcggCgccaaggcagataggcatca	16	9	1	2			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr16:75513386C>T	uc002fef.2	-	3	521	c.341G>A	c.(340-342)CGC>CAC	p.R114H	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.R114H	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	114	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						CAGGTTGCGGCGCCAAGGCAG	0.672													T	75513386	T	T	75513386	3	4	19	1	0	0	0	0	1	0	0	0	3408	768	27	1	850	1	CHST6	16	75513386	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08	17718605	75513386	14841367	45	1256											
ADAMTS18	170692	broad.mit.edu	37	chr16	77355016	77355016	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggtacaggcctttataaaaCttgcaagttgaattatcacc	7	8	1	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr16:77355016C>G	uc002ffc.3	-	15	2666	c.2247G>C	c.(2245-2247)AAG>AAC	p.K749N	ADAMTS18_uc010chc.1_Missense_Mutation_p.K337N|ADAMTS18_uc002ffe.1_Missense_Mutation_p.K445N	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	749	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CTTTATAAAACTTGCAAGTTG	0.383													G	77355016	G	G	77355016	3	3	19	1	0	0	0	0	1	0	0	0	263	564	20	5	1454	5	ADAMTS18	16	77355016	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08	1841630	77355016	12999737	46	1257											
KRT16	3868	broad.mit.edu	37	chr17	39767345	39767345	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaggaaccaggtctcagcGtctctgcggtttttctctgc	10	13	4	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr17:39767345G>A	uc002hxg.3	-	4	1048	c.909C>T	c.(907-909)GAC>GAT	p.D303D	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	303	Rod.|Coil 2.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				AGGTCTCAGCGTCTCTGCGGT	0.607													A	39767345	A	A	39767345	2	1	19	1	0	0	0	0	0	0	0	1	8453	1136	40	1		1	KRT16	17	39767345	Silent	SNP	G	TCGA-06-0140-01A-01D-1490-08		39767345	41427865	47	1258											
CILP2	148113	broad.mit.edu	37	chr19	19656153	19656153	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggcctggtggcccaacccGcaggagttccgggcctgctt	14	15	0	0			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr19:19656153G>A	uc002nmv.3	+	8	2884	c.2799G>A	c.(2797-2799)CCG>CCA	p.P933P	CILP2_uc002nmw.3_Silent_p.P939P	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	933						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GGCCCAACCCGCAGGAGTTCC	0.662													A	19656153	A	A	19656153	2	1	19	1	0	0	0	0	0	0	0	1	3430	1074	38	1		1	CILP2	19	19656153	Silent	SNP	G	TCGA-06-0140-01A-01D-1490-08		19656153	39472830	48	1259											
LMTK3	114783	broad.mit.edu	37	chr19	49013377	49013377	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgaggaggaggtctcctcCgcagggggagtgtactcccc	16	11	1	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr19:49013377C>T	uc002pjk.2	-	4	351	c.351G>A	c.(349-351)GCG>GCA	p.A117A		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		AGGTCTCCTCCGCAGGGGGAG	0.622													T	49013377	T	T	49013377	2	4	19	1	0	0	0	0	0	0	0	1	8860	639	23	2		2	LMTK3	19	49013377	Silent	SNP	C	TCGA-06-0140-01A-01D-1490-08	29357224	49013377	10115606	49	1260											
ZNF71	58491	broad.mit.edu	37	chr19	57133286	57133286	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	accagcgcacgcacacgggcGagaagccgtatgtgtgcgac	14	13	0	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr19:57133286G>A	uc002qnm.3	+	3	869	c.631G>A	c.(631-633)GAG>AAG	p.E211K		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	211						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GCACACGGGCGAGAAGCCGTA	0.657													A	57133286	A	A	57133286	3	1	19	1	0	0	0	0	1	0	0	0	18111	1059	37	2	633	2	ZNF71	19	57133286	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	8119909	57133286	1995697	50	1261											
PTPRT	11122	broad.mit.edu	37	chr20	41101086	41101086	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacacatactggtactgcaCggtgaggttgtagctatggc	13	8	0	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr20:41101086C>T	uc002xkg.2	-	8	1454	c.1270G>A	c.(1270-1272)GTG>ATG	p.V424M	PTPRT_uc010ggj.2_Missense_Mutation_p.V424M	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	424	Extracellular (Potential).|Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGTACTGCACGGTGAGGTTG	0.607													T	41101086	T	T	41101086	3	4	19	1	0	0	0	0	1	0	0	0	12812	536	19	1	3212	1	PTPRT	20	41101086	Missense_Mutation	SNP	C	TCGA-06-0140-01A-01D-1490-08		41101086	21924434	51	1262											
ADM2	79924	broad.mit.edu	37	chr22	50921222	50921222	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcgagtgggctgtgtgctgGgcacctgccaggtgcagaat	17	9	0	1			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chr22:50921222G>A	uc003blj.2	+	2	602	c.337G>A	c.(337-339)GGC>AGC	p.G113S	ADM2_uc011ary.1_Missense_Mutation_p.G113S	NM_024866	NP_079142	Q7Z4H4	ADM2_HUMAN	adrenomedullin 2 precursor	113					positive regulation of angiogenesis	extracellular region	hormone activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTGTGTGCTGGGCACCTGCCA	0.701													A	50921222	A	A	50921222	3	1	19	1	0	0	0	0	1	0	0	0	322	1232	43	3	343	3	ADM2	22	50921222	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08		50921222	383344	52	1263											
BCOR	54880	broad.mit.edu	37	chrX	39932184	39932185	+	Frame_Shift_Ins	INS	-	CAGAC	CAGAC													cttctcggagaaggtctacgINStagacaagcttgtcgctttt							TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chrX:39932184_39932185insCAGAC	uc004den.3	-	4	2706_2707	c.2414_2415insGTCTG	c.(2413-2415)TACfs	p.Y805fs	BCOR_uc004dep.3_Frame_Shift_Ins_p.Y805fs|BCOR_uc004deo.3_Frame_Shift_Ins_p.Y805fs|BCOR_uc004dem.3_Frame_Shift_Ins_p.Y805fs|BCOR_uc004deq.3_Frame_Shift_Ins_p.Y805fs	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	805					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						GAAGGTCTACGTAGACAAGCTT	0.515													CAGAC	39932185	CAGAC	CAGAC	39932184	7	5	19	1	0	1	1	0	0	0	0	0	1386	1140	40	0	2900	0	BCOR	23	39932184	Frame_Shift_Ins	INS	-	TCGA-06-0140-01A-01D-1490-08		39932184	115338376	53	1264											
AKAP4	8852	broad.mit.edu	37	chrX	49957245	49957245	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttagccatgataaggcagaGcttcatcacagattctacta	7	10	3	3			TCGA-06-0140-01A-01D-1490-08	TCGA-06-0140-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	18c94086-d2cc-45cd-9bad-f8968a042d5e	f8eb6b04-153e-4953-8582-c207a5a7cf30	g.chrX:49957245G>A	uc004dow.1	-	5	2243	c.2119C>T	c.(2119-2121)CTC>TTC	p.L707F	AKAP4_uc004dov.1_Missense_Mutation_p.L324F|AKAP4_uc010njp.1_Missense_Mutation_p.L529F|AKAP4_uc004dou.1_Missense_Mutation_p.L698F	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	707					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					ATAAGGCAGAGCTTCATCACA	0.478													A	49957245	A	A	49957245	3	1	19	1	0	0	0	0	1	0	0	0	453	971	34	3	453	3	AKAP4	23	49957245	Missense_Mutation	SNP	G	TCGA-06-0140-01A-01D-1490-08	10025061	49957245	105313315	54	1265											
CATSPER4	378807	broad.mit.edu	37	chr1	26524882	26524882	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatctgcatcacccaggacGgctgggtggacatctacagt	11	12	4	0			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr1:26524882G>A	uc010oez.1	+	6	784	c.784G>A	c.(784-786)GGC>AGC	p.G262S	CATSPER4_uc010oey.1_Missense_Mutation_p.G84S|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	262					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		CACCCAGGACGGCTGGGTGGA	0.557													A	26524882	A	A	26524882	3	1	20	1	0	0	0	0	1	0	0	0	2690	1116	39	2	806	2	CATSPER4	1	26524882	Missense_Mutation	SNP	G	TCGA-06-0141-01A-01D-1490-08		26524882	222725739	1	1266											
GFPT1	2673	broad.mit.edu	37	chr2	69583664	69583664	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcccgggaaaatgaacacttTtaaacacaagtgcaaaagca	8	9	0	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr2:69583664T>C	uc002sfh.2	-	7	748	c.569A>G	c.(568-570)AAA>AGA	p.K190R	GFPT1_uc002sfi.1_Missense_Mutation_p.K32R	NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	190	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						ATGAACACTTTTAAACACAAG	0.358													C	69583664	C	C	69583664	3	2	20	1	0	0	0	0	1	0	0	0	6345	1841	64	4	1528	4	GFPT1	2	69583664	Missense_Mutation	SNP	T	TCGA-06-0141-01A-01D-1490-08		69583664	173615709	2	1267											
SCRN3	79634	broad.mit.edu	37	chr2	175287615	175287615	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaaaattatttctctaggaAatataacttttgaaacaatg	4	4	1	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr2:175287615A>G	uc002uiq.2	+	6	845	c.757A>G	c.(757-759)AAT>GAT	p.N253D	SCRN3_uc010zen.1_Missense_Mutation_p.N246D|SCRN3_uc010zeo.1_Missense_Mutation_p.N51D|SCRN3_uc002uis.2_5'UTR	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	253					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			TTCTCTAGGAAATATAACTTT	0.318													G	175287615	G	G	175287615	3	3	20	1	0	0	0	0	1	0	0	0	13940	14	1	4	775	4	SCRN3	2	175287615	Missense_Mutation	SNP	A	TCGA-06-0141-01A-01D-1490-08	105703951	175287615	67911758	3	1268											
QRICH1	54870	broad.mit.edu	37	chr3	49094721	49094721	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atggtccaggtttctcctgtAgggctagtaatggtcccagt	12	9	1	0			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr3:49094721A>G	uc010hkq.2	-	4	1208	c.912T>C	c.(910-912)CCT>CCC	p.P304P	QRICH1_uc003cvu.2_Silent_p.P304P|QRICH1_uc003cvv.2_Silent_p.P304P	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	304	Gln-rich.									ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		TTTCTCCTGTAGGGCTAGTAA	0.557													G	49094721	G	G	49094721	2	3	20	1	0	0	0	0	0	0	0	1	12879	407	15	4		4	QRICH1	3	49094721	Silent	SNP	A	TCGA-06-0141-01A-01D-1490-08		49094721	148927709	4	1269											
N4BP2	55728	broad.mit.edu	37	chr4	40122570	40122570	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cattgggtagctccaatctaGgaagttctgaaatgctgctc	10	9	2	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr4:40122570G>T	uc003guy.3	+	9	3177	c.2839G>T	c.(2839-2841)GGA>TGA	p.G947*	N4BP2_uc010ifq.2_Nonsense_Mutation_p.G867*|N4BP2_uc010ifr.2_Nonsense_Mutation_p.G867*	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	947						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						CTCCAATCTAGGAAGTTCTGA	0.408													T	40122570	T	T	40122570	4	4	20	1	0	0	0	0	0	1	0	0	10110	1001	35	5	2865	5	N4BP2	4	40122570	Nonsense_Mutation	SNP	G	TCGA-06-0141-01A-01D-1490-08		40122570	151031706	5	1270											
LRRC66	339977	broad.mit.edu	37	chr4	52883712	52883712	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tattgctttttcttgatgcaTttgtcattattccagtaaaa	5	6	2	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr4:52883712T>C	uc003gzi.2	-	1	81	c.68A>G	c.(67-69)AAT>AGT	p.N23S		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	23	Helical; (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TCTTGATGCATTTGTCATTAT	0.299													C	52883712	C	C	52883712	3	2	20	1	0	0	0	0	1	0	0	0	9018	1493	52	4	2590	4	LRRC66	4	52883712	Missense_Mutation	SNP	T	TCGA-06-0141-01A-01D-1490-08	12761142	52883712	138270564	6	1271											
ENOPH1	58478	broad.mit.edu	37	chr4	83372300	83372300	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggccgtggtagataatgtGtgctggcagatgtccctgga	15	8	0	2	rs143039236	by1000genomes	TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr4:83372300G>A	uc003hmv.2	+	3	548	c.291G>A	c.(289-291)GTG>GTA	p.V97V	ENOPH1_uc003hmw.2_Silent_p.V9V|ENOPH1_uc003hmx.2_Intron	NM_021204	NP_067027	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	97					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity				0						TAGATAATGTGTGCTGGCAGA	0.562													A	83372300	A	A	83372300	2	1	20	1	0	0	0	0	0	0	0	1	5124	1364	48	3		3	ENOPH1	4	83372300	Silent	SNP	G	TCGA-06-0141-01A-01D-1490-08	30488588	83372300	107781976	7	1272											
ABCG2	9429	broad.mit.edu	37	chr4	89053011	89053011	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggtcgcggtgctccatttaTcagaacatctccagataatc	8	11	2	2			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr4:89053011T>C	uc003hrg.2	-	4	815	c.322A>G	c.(322-324)ATA>GTA	p.I108V	ABCG2_uc003hrh.2_Missense_Mutation_p.I108V|ABCG2_uc003hrf.2_5'UTR|ABCG2_uc003hri.1_Missense_Mutation_p.I108V|ABCG2_uc003hrj.1_Missense_Mutation_p.I108V|ABCG2_uc003hrk.1_Missense_Mutation_p.I108V	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	108	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	GCTCCATTTATCAGAACATCT	0.378													C	89053011	C	C	89053011	3	2	20	1	0	0	0	0	1	0	0	0	69	1435	50	4	1697	4	ABCG2	4	89053011	Missense_Mutation	SNP	T	TCGA-06-0141-01A-01D-1490-08	5680711	89053011	102101265	8	1273											
PCDHA13	56136	broad.mit.edu	37	chr5	140263677	140263677	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctacaatgcgtggctttcGtatgaattgcagctggcggc	14	9	0	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr5:140263677G>A	uc003lif.2	+	1	1824	c.1824G>A	c.(1822-1824)TCG>TCA	p.S608S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.S608S|PCDHA13_uc003lid.2_Silent_p.S608S	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	608	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGCTTTCGTATGAATTGC	0.682													A	140263677	A	A	140263677	2	1	20	1	0	0	0	0	0	0	0	1	11523	1132	40	1		1	PCDHA13	5	140263677	Silent	SNP	G	TCGA-06-0141-01A-01D-1490-08		140263677	40651583	9	1274											
PCDHB14	56122	broad.mit.edu	37	chr5	140604583	140604583	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cggcacctgcccctcgcctcCttggtctccatcaacgcgga	9	19	2	0			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr5:140604583C>A	uc003ljb.2	+	1	1506	c.1506C>A	c.(1504-1506)TCC>TCA	p.S502S	PCDHB14_uc011dal.1_Silent_p.S349S	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	502	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTCGCCTCCTTGGTCTCCA	0.647													A	140604583	A	A	140604583	2	1	20	1	0	0	0	0	0	0	0	1	11539	668	24	5		5	PCDHB14	5	140604583	Silent	SNP	C	TCGA-06-0141-01A-01D-1490-08	340906	140604583	40310677	10	1275											
C2	717	broad.mit.edu	37	chr6	31901955	31901955	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctccagaaagcctgggccGtaaaatccaaatccagcgct	8	13	1	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr6:31901955G>A	uc003nyf.2	+	6	992	c.728G>A	c.(727-729)CGT>CAT	p.R243H	C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_Intron|C2_uc003nye.3_Missense_Mutation_p.R243H|C2_uc010jtk.2_Missense_Mutation_p.R111H|C2_uc011doq.1_Missense_Mutation_p.R214H|C2_uc003nyg.2_Intron|CFB_uc011dor.1_Intron|C2_uc003nyh.1_5'Flank	NM_000063	NP_000054	P06681	CO2_HUMAN	complement component 2 isoform 1 preproprotein	243					complement activation, classical pathway|innate immune response|proteolysis	extracellular space	serine-type endopeptidase activity			ovary(1)|skin(1)	2		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		AGCCTGGGCCGTAAAATCCAA	0.547													A	31901955	A	A	31901955	3	1	20	1	0	0	0	0	1	0	0	0	2074	1145	40	1	827	1	C2	6	31901955	Missense_Mutation	SNP	G	TCGA-06-0141-01A-01D-1490-08		31901955	139213112	11	1276											
POM121	9883	broad.mit.edu	37	chr7	72398976	72398976	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atttgagcccctggtggccaAtggagtccccgcttcttttg	11	12	1	1	rs147859349		TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr7:72398976A>G	uc003twk.2	+	4	1076	c.1076A>G	c.(1075-1077)AAT>AGT	p.N359S	POM121_uc003twj.2_Missense_Mutation_p.N94S|POM121_uc010lam.1_Missense_Mutation_p.N94S	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	359	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				CTGGTGGCCAATGGAGTCCCC	0.468													G	72398976	G	G	72398976	3	3	20	1	0	0	0	0	1	0	0	0	12239	101	4	4	291	4	POM121	7	72398976	Missense_Mutation	SNP	A	TCGA-06-0141-01A-01D-1490-08		72398976	86739687	12	1277											
ZFAT	57623	broad.mit.edu	37	chr8	135533235	135533235	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaagctgcaaacaggacacTtcaaaccacctgaaagcaca	6	13	1	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr8:135533235T>G	uc003yup.2	-	13	3300	c.3125A>C	c.(3124-3126)AAG>ACG	p.K1042T	ZFAT_uc011ljj.1_Missense_Mutation_p.K161T|ZFAT_uc003yun.2_Missense_Mutation_p.K1030T|ZFAT_uc003yuo.2_Missense_Mutation_p.K1030T|ZFAT_uc010meh.2_Missense_Mutation_p.K1030T|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.K1030T|ZFAT_uc010mej.2_Missense_Mutation_p.K980T	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	1042	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			AACAGGACACTTCAAACCACC	0.408													G	135533235	G	G	135533235	3	3	20	1	0	0	0	0	1	0	0	0	17629	1609	56	5	622	5	ZFAT	8	135533235	Missense_Mutation	SNP	T	TCGA-06-0141-01A-01D-1490-08		135533235	10830787	13	1278											
IARS	3376	broad.mit.edu	37	chr9	95004467	95004467	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cttgaataaggactttatccGatggagaaactggatatggt	11	5	0	2			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr9:95004467G>C	uc004art.1	-	29	3403	c.3146C>G	c.(3145-3147)TCG>TGG	p.S1049W	IARS_uc004ars.1_Missense_Mutation_p.S894W|IARS_uc004aru.3_Missense_Mutation_p.S1049W|IARS_uc010mqr.2_Missense_Mutation_p.S939W|IARS_uc010mqt.2_Missense_Mutation_p.S272W	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	1049					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	GACTTTATCCGATGGAGAAAC	0.388													C	95004467	C	C	95004467	3	2	20	1	0	0	0	0	1	0	0	0	7473	1059	37	5	666	5	IARS	9	95004467	Missense_Mutation	SNP	G	TCGA-06-0141-01A-01D-1490-08		95004467	46208964	14	1279											
RSU1	6251	broad.mit.edu	37	chr10	16794981	16794981	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caaaatcgttgtcacttagaTagagtgcacgcagggtggct	12	8	1	2	rs149666298	byFrequency	TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr10:16794981T>C	uc001iok.2	-	5	721	c.419A>G	c.(418-420)TAT>TGT	p.Y140C	RSU1_uc001iol.2_Missense_Mutation_p.Y140C|RSU1_uc001iom.2_Missense_Mutation_p.Y87C|RSU1_uc001ion.2_Missense_Mutation_p.Y140C	NM_152724	NP_689937	Q15404	RSU1_HUMAN	ras suppressor protein 1 isoform 2	140	LRR 5.				cell junction assembly|signal transduction	cytosol	protein binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(1;7.54e-08)		GTCACTTAGATAGAGTGCACG	0.398													C	16794981	C	C	16794981	3	2	20	1	0	0	0	0	1	0	0	0	13716	1406	49	4	430	4	RSU1	10	16794981	Missense_Mutation	SNP	T	TCGA-06-0141-01A-01D-1490-08		16794981	118739766	15	1280											
MAP3K8	1326	broad.mit.edu	37	chr10	30739369	30739369	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggaccaatgagagaatttgaAattatttgggtgacaaagca	11	4	0	4			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr10:30739369A>G	uc001ivi.1	+	5	1383	c.687A>G	c.(685-687)GAA>GAG	p.E229E	MAP3K8_uc009xlf.1_Silent_p.E229E|MAP3K8_uc001ivj.1_Silent_p.E229E	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	229	Protein kinase.				cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)				GAGAATTTGAAATTATTTGGG	0.418													G	30739369	G	G	30739369	2	3	20	1	0	0	0	0	0	0	0	1	9256	11	1	4		4	MAP3K8	10	30739369	Silent	SNP	A	TCGA-06-0141-01A-01D-1490-08	13944388	30739369	104795378	16	1281											
ZNF37A	7587	broad.mit.edu	37	chr10	38407378	38407378	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	actaaacatctaagaactcaCacaggtgagaaaccttatga	6	9	2	3			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr10:38407378C>A	uc001izk.2	+	8	2118	c.1299C>A	c.(1297-1299)CAC>CAA	p.H433Q	ZNF37A_uc001izl.2_Missense_Mutation_p.H433Q|ZNF37A_uc001izm.2_Missense_Mutation_p.H433Q	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	433	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						TAAGAACTCACACAGGTGAGA	0.383													A	38407378	A	A	38407378	3	1	20	1	0	0	0	0	1	0	0	0	17869	477	17	5	1313	5	ZNF37A	10	38407378	Missense_Mutation	SNP	C	TCGA-06-0141-01A-01D-1490-08	7668009	38407378	97127369	17	1282											
ANK3	288	broad.mit.edu	37	chr10	61831909	61831909	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttaatttctgagagagagccGtttgttaacaatttgcgttc	9	6	1	2			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr10:61831909G>A	uc001jky.2	-	37	8922	c.8730C>T	c.(8728-8730)AAC>AAT	p.N2910N	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2910					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AGAGAGAGCCGTTTGTTAACA	0.378													A	61831909	A	A	61831909	2	1	20	1	0	0	0	0	0	0	0	1	622	1136	40	1		1	ANK3	10	61831909	Silent	SNP	G	TCGA-06-0141-01A-01D-1490-08	23424531	61831909	73702838	18	1283											
OR4C15	81309	broad.mit.edu	37	chr11	55322828	55322828	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caggaataaggaagtaaaacAggccatgaggagaatatgga	13	4	0	2			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr11:55322828A>T	uc010rig.1	+	1	1046	c.1046A>T	c.(1045-1047)CAG>CTG	p.Q349L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAAGTAAAACAGGCCATGAGG	0.328										HNSCC(20;0.049)			T	55322828	T	T	55322828	3	4	20	1	0	0	0	0	1	0	0	0	11048	188	7	5	1048	5	OR4C15	11	55322828	Missense_Mutation	SNP	A	TCGA-06-0141-01A-01D-1490-08		55322828	79683688	19	1284											
KRTAP5-10	387273	broad.mit.edu	37	chr11	71277242	71277242	+	Nonstop_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctgccagtgtaagatctgAggctctgaacccagaccttc	10	12	2	4			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr11:71277242A>G	uc001oqt.1	+	1	634	c.609A>G	c.(607-609)TGA>TGG	p.*203W		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	203						keratin filament				skin(1)	1						GTAAGATCTGAGGCTCTGAAC	0.323													G	71277242	G	G	71277242	4	3	20	1	0	0	0	0	0	0	0	0	8559	317	11	4	611	4	KRTAP5-10	11	71277242	Nonstop_Mutation	SNP	A	TCGA-06-0141-01A-01D-1490-08	15954414	71277242	63729274	20	1285											
BIRC2	329	broad.mit.edu	37	chr11	102220791	102220791	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcagaaaggagtcttgctcGtgctggtttttattatactg	10	7	2	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr11:102220791G>T	uc001pgy.2	+	2	1605	c.206G>T	c.(205-207)CGT>CTT	p.R69L	BIRC2_uc010ruq.1_Missense_Mutation_p.R20L|BIRC2_uc010rur.1_Missense_Mutation_p.R69L	NM_001166	NP_001157	Q13490	BIRC2_HUMAN	baculoviral IAP repeat-containing protein 2	69	BIR 1.				cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		AGTCTTGCTCGTGCTGGTTTT	0.423													T	102220791	T	T	102220791	3	4	20	1	0	0	0	0	1	0	0	0	1435	1145	40	5	208	5	BIRC2	11	102220791	Missense_Mutation	SNP	G	TCGA-06-0141-01A-01D-1490-08	30943549	102220791	32785725	21	1286											
KLRC3	3823	broad.mit.edu	37	chr12	10573038	10573038	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtttaattctacttggaataTttcctgttcggttcctgaaa	7	7	1	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr12:10573038T>C	uc001qyf.2	-	1	157	c.112A>G	c.(112-114)ATA>GTA	p.I38V	KLRC3_uc001qyh.2_Intron|KLRC3_uc001qyi.1_Missense_Mutation_p.I38V|KLRC3_uc010shc.1_Missense_Mutation_p.I38V|KLRC3_uc010shd.1_Missense_Mutation_p.I38V	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	38	Cytoplasmic (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ACTTGGAATATTTCCTGTTCG	0.378													C	10573038	C	C	10573038	3	2	20	1	0	0	0	0	1	0	0	0	8417	1493	52	4	734	4	KLRC3	12	10573038	Missense_Mutation	SNP	T	TCGA-06-0141-01A-01D-1490-08		10573038	123278857	22	1287											
KLRC3	3823	broad.mit.edu	37	chr12	10588474	10588474	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atttaattctacttggaataTttcctgttcggttcctgaaa	6	7	1	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr12:10588474T>C	uc001qyh.2	-	1	119	c.112A>G	c.(112-114)ATA>GTA	p.I38V	KLRC2_uc010she.1_Missense_Mutation_p.I38V|KLRC2_uc001qyk.2_Missense_Mutation_p.I38V	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	38	Cytoplasmic (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ACTTGGAATATTTCCTGTTCG	0.383													C	10588474	C	C	10588474	3	2	20	1	0	0	0	0	1	0	0	0	8417	1493	52	4		4	KLRC3	12	10588474	Missense_Mutation	SNP	T	TCGA-06-0141-01A-01D-1490-08	15436	10588474	123263421	23	1288											
TMCC3	57458	broad.mit.edu	37	chr12	94975965	94975965	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagaggctccattctgctcgAtctctctgagctttcgatga	9	11	3	3			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr12:94975965A>G	uc001tdj.2	-	2	546	c.428T>C	c.(427-429)ATC>ACC	p.I143T	TMCC3_uc001tdi.2_Missense_Mutation_p.I112T	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	143	Potential.					integral to membrane				ovary(1)|skin(1)	2						ATTCTGCTCGATCTCTCTGAG	0.458													G	94975965	G	G	94975965	3	3	20	1	0	0	0	0	1	0	0	0	15991	333	12	4	1017	4	TMCC3	12	94975965	Missense_Mutation	SNP	A	TCGA-06-0141-01A-01D-1490-08	84387491	94975965	38875930	24	1289											
SACS	26278	broad.mit.edu	37	chr13	23928995	23928995	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttgagcacagtttttgtgtAttctaaattttcatcaagtt	7	5	3	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr13:23928995A>G	uc001uon.2	-	8	2345	c.1756T>C	c.(1756-1758)TAC>CAC	p.Y586H	SACS_uc001uoo.2_Missense_Mutation_p.Y439H|SACS_uc001uop.1_Missense_Mutation_p.Y373H|SACS_uc001uoq.1_Missense_Mutation_p.Y439H	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	586					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GTTTTTGTGTATTCTAAATTT	0.468													G	23928995	G	G	23928995	3	3	20	1	0	0	0	0	1	0	0	0	13804	449	16	4	11995	4	SACS	13	23928995	Missense_Mutation	SNP	A	TCGA-06-0141-01A-01D-1490-08		23928995	91240883	25	1290											
UBE3A	7337	broad.mit.edu	37	chr15	25616938	25616938	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caagaatttcatataccttcTcttctgttaagtaagtcaca	4	9	4	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr15:25616938T>C	uc001zaq.2	-	4	392	c.392A>G	c.(391-393)GAG>GGG	p.E131G	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.E108G|UBE3A_uc001zas.2_Missense_Mutation_p.E128G|UBE3A_uc001zat.2_Missense_Mutation_p.E108G	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	131					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		ATATACCTTCTCTTCTGTTAA	0.308													C	25616938	C	C	25616938	3	2	20	1	0	0	0	0	1	0	0	0	16876	1551	54	4	2267	4	UBE3A	15	25616938	Missense_Mutation	SNP	T	TCGA-06-0141-01A-01D-1490-08		25616938	76914454	26	1291											
MIS12	79003	broad.mit.edu	37	chr17	5392643	5392643	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgttcaggccaaactcaaacAgacgttgactttctttgatg	8	9	3	3			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr17:5392643A>G	uc002gcd.2	+	2	790	c.461A>G	c.(460-462)CAG>CGG	p.Q154R	MIS12_uc002gce.2_Missense_Mutation_p.Q154R	NM_024039	NP_076944	Q9H081	MIS12_HUMAN	MIS12 homolog	154	Potential.				cell division|chromosome segregation|kinetochore assembly|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding				0						AAACTCAAACAGACGTTGACT	0.393													G	5392643	G	G	5392643	3	3	20	1	0	0	0	0	1	0	0	0	9594	188	7	4	463	4	MIS12	17	5392643	Missense_Mutation	SNP	A	TCGA-06-0141-01A-01D-1490-08		5392643	75802567	27	1292											
MYH2	4620	broad.mit.edu	37	chr17	10430104	10430104	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagggcatgcgccagggcGttcttggcctatggaggcag	17	10	1	0			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr17:10430104G>A	uc010coi.2	-	30	4127	c.3999C>T	c.(3997-3999)AAC>AAT	p.N1333N	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.N1333N|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1333	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GCGCCAGGGCGTTCTTGGCCT	0.498													A	10430104	A	A	10430104	2	1	20	1	0	0	0	0	0	0	0	1	10035	1136	40	1		1	MYH2	17	10430104	Silent	SNP	G	TCGA-06-0141-01A-01D-1490-08	5037461	10430104	70765106	28	1293											
MALT1	10892	broad.mit.edu	37	chr18	56378165	56378165	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaggaagaacagatgAggcagtggagtgcactgaag	15	5	0	4			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr18:56378165A>G	uc002lhm.1	+	7	1196	c.938A>G	c.(937-939)GAG>GGG	p.E313G	MALT1_uc002lhn.1_Intron	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	313					activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						AGAACAGATGAGGCAGTGGAG	0.388			T	BIRC3	MALT								G	56378165	G	G	56378165	3	3	20	1	0	0	0	0	1	0	0	0	9202	304	11	4	964	4	MALT1	18	56378165	Missense_Mutation	SNP	A	TCGA-06-0141-01A-01D-1490-08		56378165	21699083	29	1294											
ZNF28	7576	broad.mit.edu	37	chr19	53303147	53303147	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaagcctatgatggtataCgagggatgacatctgactga	12	6	1	5	rs146037495		TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chr19:53303147C>T	uc002qad.2	-	4	2071	c.1951G>A	c.(1951-1953)GTA>ATA	p.V651I	ZNF28_uc002qac.2_Missense_Mutation_p.V598I|ZNF28_uc010eqe.2_Missense_Mutation_p.V597I	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	651	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TGATGGTATACGAGGGATGAC	0.423													T	53303147	T	T	53303147	3	4	20	1	0	0	0	0	1	0	0	0	17810	536	19	1	209	1	ZNF28	19	53303147	Missense_Mutation	SNP	C	TCGA-06-0141-01A-01D-1490-08		53303147	5825836	30	1295											
DCAF12L2	340578	broad.mit.edu	37	chrX	125298905	125298905	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgttctgctggcgctggcGcggatccaggaaggagacgt	17	9	1	1			TCGA-06-0141-01A-01D-1490-08	TCGA-06-0141-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	5af251d5-e76b-480c-8142-6d6fbfce0b2a	c6f91567-fa3d-4920-80e6-bc04a5c0c9b1	g.chrX:125298905G>A	uc004euk.1	-	1	1030	c.1003C>T	c.(1003-1005)CGC>TGC	p.R335C		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	335										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						TGGCGCTGGCGCGGATCCAGG	0.627													A	125298905	A	A	125298905	3	1	20	1	0	0	0	0	1	0	0	0	4265	1087	38	1	392	1	DCAF12L2	23	125298905	Missense_Mutation	SNP	G	TCGA-06-0141-01A-01D-1490-08		125298905	29971655	31	1296											
EPHB2	2048	broad.mit.edu	37	chr1	23208926	23208926	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccctgtcgtggtcccagccgGaccagcccaatggcgtgatc	12	16	0	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr1:23208926G>A	uc009vqj.1	+	6	1523	c.1378G>A	c.(1378-1380)GAC>AAC	p.D460N	EPHB2_uc001bge.2_Missense_Mutation_p.D460N|EPHB2_uc001bgf.2_Missense_Mutation_p.D460N|EPHB2_uc010odu.1_Missense_Mutation_p.D460N	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	460	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GTCCCAGCCGGACCAGCCCAA	0.607									Hereditary_Prostate_Cancer				A	23208926	A	A	23208926	3	1	21	1	0	0	0	0	1	0	0	0	5175	1174	41	3	1400	3	EPHB2	1	23208926	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08		23208926	226041695	1	1297											
AMPD2	271	broad.mit.edu	37	chr1	110171969	110171969	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggatggttttgacagcgtGgatgatgagtccaagcctga	15	6	0	4			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr1:110171969G>A	uc009wfh.1	+	15	2423	c.1881G>A	c.(1879-1881)GTG>GTA	p.V627V	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Silent_p.V546V|AMPD2_uc001dyc.1_Silent_p.V627V|AMPD2_uc010ovr.1_Silent_p.V552V|AMPD2_uc001dyd.1_Silent_p.V508V|AMPD2_uc001dye.1_5'UTR	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	627					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		TTGACAGCGTGGATGATGAGT	0.587													A	110171969	A	A	110171969	2	1	21	1	0	0	0	0	0	0	0	1	586	1335	47	3		3	AMPD2	1	110171969	Silent	SNP	G	TCGA-06-0142-01A-01D-1490-08	86963043	110171969	139078652	2	1298											
COPA	1314	broad.mit.edu	37	chr1	160268961	160268961	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatcaatggtgagtacccgGggacgacactccctgtctag	13	11	2	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr1:160268961G>A	uc009wti.2	-	18	2155	c.1761C>T	c.(1759-1761)CCC>CCT	p.P587P	COPA_uc001fvv.3_Silent_p.P596P	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	587					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGAGTACCCGGGGACGACACT	0.463													A	160268961	A	A	160268961	2	1	21	1	0	0	0	0	0	0	0	1	3727	1219	43	3		3	COPA	1	160268961	Silent	SNP	G	TCGA-06-0142-01A-01D-1490-08	50096992	160268961	88981660	3	1299											
EPHX1	2052	broad.mit.edu	37	chr1	226027691	226027691	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtattctacagcctgatgaGggagagcggctacatgcaca	13	9	1	3			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr1:226027691G>A	uc001hpk.2	+	6	964	c.884G>A	c.(883-885)AGG>AAG	p.R295K	EPHX1_uc001hpl.2_Missense_Mutation_p.R295K	NM_001136018	NP_001129490	P07099	HYEP_HUMAN	epoxide hydrolase 1	295					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			ovary(3)|lung(1)	4	Breast(184;0.197)					AGCCTGATGAGGGAGAGCGGC	0.607													A	226027691	A	A	226027691	3	1	21	1	0	0	0	0	1	0	0	0	5179	1000	35	3	902	3	EPHX1	1	226027691	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	65758730	226027691	23222930	4	1300											
BIRC6	57448	broad.mit.edu	37	chr2	32740406	32740406	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcttcttgtgaggagtctgGctagtttctgctttagccac	10	10	4	1	rs112352145		TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr2:32740406G>A	uc010ezu.2	+	55	11052	c.10918G>A	c.(10918-10920)GCT>ACT	p.A3640T		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3640					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GAGGAGTCTGGCTAGTTTCTG	0.438													A	32740406	A	A	32740406	3	1	21	1	0	0	0	0	1	0	0	0	1438	1203	42	3	11136	3	BIRC6	2	32740406	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08		32740406	210458967	5	1301											
RGPD4	285190	broad.mit.edu	37	chr2	108476261	108476261	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaaaacatggccttcaacCtgctctgcttgtacattggg	10	10	2	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr2:108476261C>T	uc010ywk.1	+	12	1800	c.1718C>T	c.(1717-1719)CCT>CTT	p.P573L	RGPD4_uc002tdu.2_5'UTR|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	573					intracellular transport		binding			skin(2)	2						GGCCTTCAACCTGCTCTGCTT	0.328													T	108476261	T	T	108476261	3	4	21	1	0	0	0	0	1	0	0	0	13288	681	24	3	1764	3	RGPD4	2	108476261	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	75735855	108476261	134723112	6	1302											
GCC2	9648	broad.mit.edu	37	chr2	109103046	109103046	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcggaacagcaccagcgtaCgctaagtgcataccagcaga	11	12	0	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr2:109103046C>T	uc002tec.2	+	16	4026	c.3872C>T	c.(3871-3873)ACG>ATG	p.T1291M	GCC2_uc002ted.2_Missense_Mutation_p.T1190M	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1291	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						CACCAGCGTACGCTAAGTGCA	0.502													T	109103046	T	T	109103046	3	4	21	1	0	0	0	0	1	0	0	0	6286	536	19	1	3934	1	GCC2	2	109103046	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	626785	109103046	134096327	7	1303											
ITGA4	3676	broad.mit.edu	37	chr2	182386969	182386969	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggagtatgaagacattgatGttgaatgtgtccttgtttaa	12	3	0	4			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr2:182386969G>A	uc002unu.2	+	18	2737	c.1974G>A	c.(1972-1974)ATG>ATA	p.M658I	ITGA4_uc010frj.1_Missense_Mutation_p.M140I|ITGA4_uc002unv.2_5'UTR	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	658	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	AGACATTGATGTTGAATGTGT	0.333													A	182386969	A	A	182386969	3	1	21	1	0	0	0	0	1	0	0	0	7878	1377	48	3	2044	3	ITGA4	2	182386969	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	73283923	182386969	60812404	8	1304											
VIL1	7429	broad.mit.edu	37	chr2	219301876	219301876	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggattgggaaacatgccaaCgaggaggagaagaaggccgc	16	7	0	2			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr2:219301876C>T	uc002via.2	+	17	2066	c.2001C>T	c.(1999-2001)AAC>AAT	p.N667N	VIL1_uc010zke.1_Silent_p.N356N|VIL1_uc002vib.2_Silent_p.N667N	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	667	Gelsolin-like 6.|Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AACATGCCAACGAGGAGGAGA	0.572													T	219301876	T	T	219301876	2	4	21	1	0	0	0	0	0	0	0	1	17161	535	19	1		1	VIL1	2	219301876	Silent	SNP	C	TCGA-06-0142-01A-01D-1490-08	36914907	219301876	23897497	9	1305											
PAX3	5077	broad.mit.edu	37	chr2	223084911	223084911	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcatggggttggagggccccGacggaggcacaaagctgtct	16	10	2	0	rs45607236		TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr2:223084911G>A	uc010fwo.2	-	7	1487	c.1121C>T	c.(1120-1122)TCG>TTG	p.S374L	PAX3_uc002vmt.1_Missense_Mutation_p.S374L|PAX3_uc002vmy.1_Missense_Mutation_p.S373L|PAX3_uc002vmv.1_Missense_Mutation_p.S374L|PAX3_uc002vmw.1_Missense_Mutation_p.S374L|PAX3_uc002vmx.1_Missense_Mutation_p.S374L	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	374					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGGGCCCCGACGGAGGCAC	0.552			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						A	223084911	A	A	223084911	3	1	21	1	0	0	0	0	1	0	0	0	11480	1059	37	2	440	2	PAX3	2	223084911	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	3783035	223084911	20114462	10	1306											
C2orf57	165100	broad.mit.edu	37	chr2	232457869	232457869	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaacatctggagacaaagaCaagagtgcagttgttccaga	10	8	2	4			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr2:232457869C>T	uc002vrz.2	+	1	258	c.207C>T	c.(205-207)GAC>GAT	p.D69D		NM_152614	NP_689827	Q53QW1	CB057_HUMAN	hypothetical protein LOC165100	69										ovary(1)	1		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		GAGACAAAGACAAGAGTGCAG	0.532													T	232457869	T	T	232457869	2	4	21	1	0	0	0	0	0	0	0	1	2178	477	17	3		3	C2orf57	2	232457869	Silent	SNP	C	TCGA-06-0142-01A-01D-1490-08	9372958	232457869	10741504	11	1307											
CCR8	1237	broad.mit.edu	37	chr3	39374277	39374277	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgatcaggatgggcacaaCgctgtgcctggcagtatggc	15	10	1	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr3:39374277C>T	uc010hhr.2	+	2	593	c.455C>T	c.(454-456)ACG>ATG	p.T152M	CCR8_uc003cjm.2_Missense_Mutation_p.T69M	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	152	Helical; Name=4; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		ATGGGCACAACGCTGTGCCTG	0.502													T	39374277	T	T	39374277	3	4	21	1	0	0	0	0	1	0	0	0	2947	536	19	1	457	1	CCR8	3	39374277	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08		39374277	158648153	12	1308											
CAMKV	79012	broad.mit.edu	37	chr3	49898275	49898275	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcatagaaaggtggatTgcctgaaagcctgcatgggg	13	9	1	2			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr3:49898275T>C	uc003cxt.1	-	8	842	c.649A>G	c.(649-651)AAT>GAT	p.N217D	CAMKV_uc011bcy.1_Missense_Mutation_p.N142D|CAMKV_uc003cxv.1_Missense_Mutation_p.N189D|CAMKV_uc003cxw.1_Missense_Mutation_p.N49D|CAMKV_uc003cxx.1_Missense_Mutation_p.N49D|CAMKV_uc003cxu.2_Missense_Mutation_p.N217D|CAMKV_uc011bcz.1_Missense_Mutation_p.N180D|CAMKV_uc011bda.1_Missense_Mutation_p.N174D|CAMKV_uc011bdb.1_RNA	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	217	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		AAAGGTGGATTGCCTGAAAGC	0.512													C	49898275	C	C	49898275	3	2	21	1	0	0	0	0	1	0	0	0	2608	1812	63	4	872	4	CAMKV	3	49898275	Missense_Mutation	SNP	T	TCGA-06-0142-01A-01D-1490-08	10523998	49898275	148124155	13	1309											
NSUN3	63899	broad.mit.edu	37	chr3	93813043	93813043	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ggtggctaaggcagacgttgGaatctttcatcccacagcct	11	11	2	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr3:93813043G>C	uc003drl.1	+	4	642	c.526G>C	c.(526-528)GAA>CAA	p.E176Q		NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	176							methyltransferase activity			skin(1)	1						GCAGACGTTGGAATCTTTCAT	0.368													C	93813043	C	C	93813043	3	2	21	1	0	0	0	0	1	0	0	0	10679	1175	41	5	540	5	NSUN3	3	93813043	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	43914768	93813043	104209387	14	1310											
RBM47	54502	broad.mit.edu	37	chr4	40440502	40440502	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgagcaggcggcccgggcGgatctcgtagttgttgagct	17	11	1	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr4:40440502G>A	uc003gvc.2	-	4	1119	c.409C>T	c.(409-411)CGC>TGC	p.R137C	RBM47_uc003gvd.2_Missense_Mutation_p.R137C|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.R99C|RBM47_uc003gvg.1_Missense_Mutation_p.R137C	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	137	RRM 1.					nucleus	nucleotide binding|RNA binding			breast(3)	3						CGGCCCGGGCGGATCTCGTAG	0.622													A	40440502	A	A	40440502	3	1	21	1	0	0	0	0	1	0	0	0	13141	1116	39	2	1388	2	RBM47	4	40440502	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08		40440502	150713774	15	1311											
KDR	3791	broad.mit.edu	37	chr4	55955885	55955885	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatatttcccacagcaaaaCaccaaaagaccagacgtcac	4	13	1	2			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr4:55955885C>T	uc003has.2	-	24	3579	c.3277G>A	c.(3277-3279)GTT>ATT	p.V1093I	KDR_uc003hat.1_Missense_Mutation_p.V1093I	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1093	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CACAGCAAAACACCAAAAGAC	0.433			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			T	55955885	T	T	55955885	3	4	21	1	0	0	0	0	1	0	0	0	8139	478	17	3	821	3	KDR	4	55955885	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	15515383	55955885	135198391	16	1312											
BMP2K	55589	broad.mit.edu	37	chr4	79772148	79772148	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagagtcaggttgctatctGtgatggcaacttcaccatcc	10	10	3	2			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr4:79772148G>A	uc003hlk.2	+	7	987	c.821G>A	c.(820-822)TGT>TAT	p.C274Y	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Missense_Mutation_p.C274Y	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	274	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						GTTGCTATCTGTGATGGCAAC	0.363													A	79772148	A	A	79772148	3	1	21	1	0	0	0	0	1	0	0	0	1460	1377	48	3	847	3	BMP2K	4	79772148	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	23816263	79772148	111382128	17	1313											
ENPEP	2028	broad.mit.edu	37	chr4	111397732	111397732	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacggcgggccgggcactgcGccagctccttcccacctgcc	13	19	0	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr4:111397732G>A	uc003iab.3	+	1	504	c.162G>A	c.(160-162)GCG>GCA	p.A54A		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	54	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CGGGCACTGCGCCAGCTCCTT	0.647													A	111397732	A	A	111397732	2	1	21	1	0	0	0	0	0	0	0	1	5128	1074	38	1		1	ENPEP	4	111397732	Silent	SNP	G	TCGA-06-0142-01A-01D-1490-08	31625584	111397732	79756544	18	1314											
C4orf46	201725	broad.mit.edu	37	chr4	159590866	159590866	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgaaggcaagttcttccaCttgagctgatactgcagatg	10	8	1	4			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr4:159590866C>T	uc003iqa.2	-	2	490	c.241G>A	c.(241-243)GTG>ATG	p.V81M	C4orf46_uc010iqp.1_RNA|ETFDH_uc010iqq.2_5'Flank|ETFDH_uc003iqb.2_5'Flank|ETFDH_uc011cjg.1_5'Flank|ETFDH_uc010iqr.2_5'Flank	NM_001008393	NP_001008394	Q504U0	CD046_HUMAN	hypothetical protein LOC201725	81										skin(1)	1						AGTTCTTCCACTTGAGCTGAT	0.363													T	159590866	T	T	159590866	3	4	21	1	0	0	0	0	1	0	0	0	2274	565	20	3	104	3	C4orf46	4	159590866	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	48193134	159590866	31563410	19	1315											
HCN1	348980	broad.mit.edu	37	chr5	45695840	45695840	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcctgctccttttccaccGccttctggctcccaaacatg	5	17	1	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr5:45695840G>A	uc003jok.2	-	1	381	c.356C>T	c.(355-357)GCG>GTG	p.A119V		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	119	Involved in subunit assembly (By similarity).|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTTTTCCACCGCCTTCTGGCT	0.602													A	45695840	A	A	45695840	3	1	21	1	0	0	0	0	1	0	0	0	6996	1087	38	1	2348	1	HCN1	5	45695840	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08		45695840	135219420	20	1316											
TMEM161B	153396	broad.mit.edu	37	chr5	87516531	87516531	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctggtattctggaaagtaatGcaatgctggaaagaaaaaaa	10	4	1	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr5:87516531G>C	uc003kjc.2	-	5	420	c.295C>G	c.(295-297)CAT>GAT	p.H99D	TMEM161B_uc011cty.1_Missense_Mutation_p.H88D|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctz.1_5'UTR|TMEM161B_uc011ctx.1_5'UTR	NM_153354	NP_699185	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	99						integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		GGAAAGTAATGCAATGCTGGa	0.294													C	87516531	C	C	87516531	3	2	21	1	0	0	0	0	1	0	0	0	16074	1319	46	5	1200	5	TMEM161B	5	87516531	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	41820691	87516531	93398729	21	1317											
BRD8	10902	broad.mit.edu	37	chr5	137485483	137485483	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttggattcttgctgagcctCcccctaggaatgccaggaaa	10	11	1	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr5:137485483C>T	uc003lcf.1	-	23	3179	c.3124G>A	c.(3124-3126)GAG>AAG	p.E1042K	BRD8_uc003lcc.1_Intron	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	1042					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGCTGAGCCTCCCCCTAGGAA	0.458													T	137485483	T	T	137485483	3	4	21	1	0	0	0	0	1	0	0	0	1506	864	30	3	603	3	BRD8	5	137485483	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	49968952	137485483	43429777	22	1318											
PCDHB14	56122	broad.mit.edu	37	chr5	140605384	140605384	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagttcaaatttctgaagccGattatccccaattttcaagt	6	9	3	1	rs147177582		TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr5:140605384G>A	uc003ljb.2	+	1	2307	c.2307G>A	c.(2305-2307)CCG>CCA	p.P769P	PCDHB14_uc011dal.1_Silent_p.P616P	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	769	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCTGAAGCCGATTATCCCCA	0.448													A	140605384	A	A	140605384	2	1	21	1	0	0	0	0	0	0	0	1	11539	1045	37	2		2	PCDHB14	5	140605384	Silent	SNP	G	TCGA-06-0142-01A-01D-1490-08	3119901	140605384	40309876	23	1319											
ARAP3	64411	broad.mit.edu	37	chr5	141035273	141035273	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtgccaaacttctgacggGcaaggtcagaggaggaatgg	15	7	2	2			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr5:141035273G>A	uc003llm.2	-	31	4103	c.4025C>T	c.(4024-4026)GCC>GTC	p.A1342V	ARAP3_uc003lll.2_Missense_Mutation_p.A293V|ARAP3_uc011dbe.1_Missense_Mutation_p.A1004V|ARAP3_uc003lln.2_Missense_Mutation_p.A1173V	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1342					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CTTCTGACGGGCAAGGTCAGA	0.592													A	141035273	A	A	141035273	3	1	21	1	0	0	0	0	1	0	0	0	840	1203	42	3	621	3	ARAP3	5	141035273	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	429889	141035273	39879987	24	1320											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	21	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08		55221822	103916841	25	1321											
TM7SF4	81501	broad.mit.edu	37	chr8	105361477	105361477	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcactggcctcttcatgaagCgatttttgggcccttgtggt	12	10	2	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr8:105361477C>T	uc003ylx.1	+	2	746	c.697C>T	c.(697-699)CGA>TGA	p.R233*		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	233					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTCATGAAGCGATTTTTGGG	0.498													T	105361477	T	T	105361477	4	4	21	1	0	0	0	0	0	1	0	0	15973	760	27	1	699	1	TM7SF4	8	105361477	Nonsense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08		105361477	41002545	26	1322											
TG	7038	broad.mit.edu	37	chr8	134144071	134144071	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcagcctggagctgctggcGgatgttcagtttgccttggg	15	10	2	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr8:134144071G>A	uc003ytw.2	+	46	7919	c.7878G>A	c.(7876-7878)GCG>GCA	p.A2626A	TG_uc010mdw.2_Silent_p.A1385A|TG_uc011ljb.1_Silent_p.A995A|TG_uc011ljc.1_Silent_p.A759A	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2626					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCTGCTGGCGGATGTTCAGT	0.458													A	134144071	A	A	134144071	2	1	21	1	0	0	0	0	0	0	0	1	15810	1103	39	2		2	TG	8	134144071	Silent	SNP	G	TCGA-06-0142-01A-01D-1490-08	28782594	134144071	12219951	27	1323											
DNAI1	27019	broad.mit.edu	37	chr9	34489407	34489407	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctgatccccaaagactcagaTgaaggacggcggcagcatta	11	11	1	4			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr9:34489407T>A	uc003zum.2	+	5	541	c.348T>A	c.(346-348)GAT>GAA	p.D116E		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	116					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		AAGACTCAGATGAAGGACGGC	0.527									Kartagener_syndrome				A	34489407	A	A	34489407	3	1	21	1	0	0	0	0	1	0	0	0	4609	1461	51	5	366	5	DNAI1	9	34489407	Missense_Mutation	SNP	T	TCGA-06-0142-01A-01D-1490-08		34489407	106724024	28	1324											
ZNF462	58499	broad.mit.edu	37	chr9	109688130	109688130	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accattggaaaatgagacagAcagccacccctcttccagca	7	14	1	2			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr9:109688130A>C	uc004bcz.2	+	3	2226	c.1937A>C	c.(1936-1938)GAC>GCC	p.D646A	ZNF462_uc010mto.2_Missense_Mutation_p.D494A|ZNF462_uc004bda.2_Missense_Mutation_p.D494A	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	646					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						AATGAGACAGACAGCCACCCC	0.463													C	109688130	C	C	109688130	3	2	21	1	0	0	0	0	1	0	0	0	17923	275	10	5	1943	5	ZNF462	9	109688130	Missense_Mutation	SNP	A	TCGA-06-0142-01A-01D-1490-08	75198723	109688130	31525301	29	1325											
LRRC18	474354	broad.mit.edu	37	chr10	50121549	50121549	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattctattcaggttgtcccGggcgttttggcattttctca	10	9	3	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr10:50121549G>A	uc001jhd.2	-	1	732	c.652C>T	c.(652-654)CGG>TGG	p.R218W	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Missense_Mutation_p.R218W	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	218						cytoplasm				ovary(1)|pancreas(1)	2						AGGTTGTCCCGGGCGTTTTGG	0.498													A	50121549	A	A	50121549	3	1	21	1	0	0	0	0	1	0	0	0	8974	1115	39	2	141	2	LRRC18	10	50121549	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08		50121549	85413198	30	1326											
OR56B1	387748	broad.mit.edu	37	chr11	5758585	5758585	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agagatgaaggctactttgaTtccagttctacttaatgtgt	9	6	1	3			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr11:5758585T>C	uc001mbt.1	+	1	839	c.839T>C	c.(838-840)ATT>ACT	p.I280T	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005180	NP_001005180	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B,	280	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GCTACTTTGATTCCAGTTCTA	0.428													C	5758585	C	C	5758585	3	2	21	1	0	0	0	0	1	0	0	0	11137	1493	52	4	841	4	OR56B1	11	5758585	Missense_Mutation	SNP	T	TCGA-06-0142-01A-01D-1490-08		5758585	129247931	31	1327											
TRPC6	7225	broad.mit.edu	37	chr11	101323720	101323720	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctcttgatttggttccatgGataatttctctccaagttct	6	10	3	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr11:101323720G>A	uc001pgk.3	-	13	3187	c.2762C>T	c.(2761-2763)TCC>TTC	p.S921F	TRPC6_uc009ywy.2_Missense_Mutation_p.S805F	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	921	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TGGTTCCATGGATAATTTCTC	0.348													A	101323720	A	A	101323720	3	1	21	1	0	0	0	0	1	0	0	0	16580	1174	41	3	37	3	TRPC6	11	101323720	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	95565135	101323720	33682796	32	1328											
ITGA5	3678	broad.mit.edu	37	chr12	54793512	54793512	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggggcccgagctcacagcGcagcctgaaacactcagcct	11	16	2	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr12:54793512G>A	uc001sga.2	-	27	2826	c.2758C>T	c.(2758-2760)CGC>TGC	p.R920C		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	920	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						AGCTCACAGCGCAGCCTGAAA	0.552											OREG0021897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	54793512	A	A	54793512	3	1	21	1	0	0	0	0	1	0	0	0	7879	1087	38	1	407	1	ITGA5	12	54793512	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08		54793512	79058383	33	1329											
OR4K13	390433	broad.mit.edu	37	chr14	20502539	20502539	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catgtaatggaggggtttgcAtatggcaacatacctgtcta	11	7	1	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr14:20502539A>G	uc010tkz.1	-	1	379	c.379T>C	c.(379-381)TGC>CGC	p.C127R		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AGGGGTTTGCATATGGCAACA	0.478													G	20502539	G	G	20502539	3	3	21	1	0	0	0	0	1	0	0	0	11068	217	8	4	537	4	OR4K13	14	20502539	Missense_Mutation	SNP	A	TCGA-06-0142-01A-01D-1490-08		20502539	86847001	34	1330											
NID2	22795	broad.mit.edu	37	chr14	52535489	52535489	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agggggctgaacttacgtagAggttgctgaatcgggcttcg	16	7	0	3			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr14:52535489A>G	uc001wzo.2	-	1	458	c.224T>C	c.(223-225)CTC>CCC	p.L75P	NID2_uc010tqs.1_Missense_Mutation_p.L75P|NID2_uc010tqt.1_Missense_Mutation_p.L75P|NID2_uc001wzp.2_Missense_Mutation_p.L75P	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	75						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					ACTTACGTAGAGGTTGCTGAA	0.612													G	52535489	G	G	52535489	3	3	21	1	0	0	0	0	1	0	0	0	10415	304	11	4	3991	4	NID2	14	52535489	Missense_Mutation	SNP	A	TCGA-06-0142-01A-01D-1490-08	32032950	52535489	54814051	35	1331											
OTX2	5015	broad.mit.edu	37	chr14	57269073	57269073	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcgattcttaaaccataCcttggaagggaaagaaaatt	7	7	2	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr14:57269073C>T	uc001xcp.2	-	3	421	c.250G>A	c.(250-252)GTA>ATA	p.V84I	OTX2_uc010aou.2_Missense_Mutation_p.V84I|OTX2_uc001xcq.2_Missense_Mutation_p.V92I	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	84	Homeobox.				axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					TTAAACCATACCTTGGAAGGG	0.418													T	57269073	T	T	57269073	3	4	21	1	0	0	0	0	1	0	0	0	11321	521	18	3	623	3	OTX2	14	57269073	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	4733584	57269073	50080467	36	1332											
TMEM229B	161145	broad.mit.edu	37	chr14	67940183	67940183	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagggctagggcgccgctgGgctccccgggctcagcgtcc	16	17	1	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr14:67940183G>A	uc001xjk.2	-	3	868	c.458C>T	c.(457-459)CCC>CTC	p.P153L	TMEM229B_uc001xjj.1_RNA	NM_182526	NP_872332	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	153	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1						GGCGCCGCTGGGCTCCCCGGG	0.647													A	67940183	A	A	67940183	3	1	21	1	0	0	0	0	1	0	0	0	16145	1232	43	3	49	3	TMEM229B	14	67940183	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	10671110	67940183	39409357	37	1333											
KLC1	3831	broad.mit.edu	37	chr14	104135871	104135871	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcagaataaatacaaagatgCagctaacctactgaatgatg	7	7	1	4			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr14:104135871C>A	uc001yno.2	+	6	1129	c.821C>A	c.(820-822)GCA>GAA	p.A274E	KLC1_uc010tyd.1_Missense_Mutation_p.A433E|KLC1_uc010tye.1_Missense_Mutation_p.A270E|KLC1_uc001ynm.1_Missense_Mutation_p.A274E|KLC1_uc001ynn.1_Missense_Mutation_p.A268E|KLC1_uc010tyf.1_Missense_Mutation_p.A274E	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2	274	TPR 2.				blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				TACAAAGATGCAGCTAACCTA	0.303													A	104135871	A	A	104135871	3	1	21	1	0	0	0	0	1	0	0	0	8333	710	25	5	839	5	KLC1	14	104135871	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	36195688	104135871	3213669	38	1334											
HDC	3067	broad.mit.edu	37	chr15	50534668	50534668	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgggcagtggcttctgagcaCtcactggcacactgttgcaa	12	11	2	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr15:50534668C>A	uc001zxz.2	-	12	1884	c.1778G>T	c.(1777-1779)AGT>ATT	p.S593I	HDC_uc001zxy.2_Missense_Mutation_p.S336I|HDC_uc010uff.1_Missense_Mutation_p.S560I	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	593					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	CTTCTGAGCACTCACTGGCAC	0.532													A	50534668	A	A	50534668	3	1	21	1	0	0	0	0	1	0	0	0	7015	565	20	5	214	5	HDC	15	50534668	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08		50534668	51996724	39	1335											
MESP2	145873	broad.mit.edu	37	chr15	90321328	90321328	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctccagagccctgtctgtcGctgggagctccatctctcct	9	16	3	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr15:90321328G>A	uc002bon.2	+	2	957	c.957G>A	c.(955-957)TCG>TCA	p.S319S	MESP2_uc010uqa.1_Silent_p.S21S	NM_001039958	NP_001035047	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog	319					Notch signaling pathway	nucleus	DNA binding				0	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			CCTGTCTGTCGCTGGGAGCTC	0.597													A	90321328	A	A	90321328	2	1	21	1	0	0	0	0	0	0	0	1	9483	1074	38	1		1	MESP2	15	90321328	Silent	SNP	G	TCGA-06-0142-01A-01D-1490-08	39786660	90321328	12210064	40	1336											
AP3S2	10239	broad.mit.edu	37	chr15	90451602	90451602	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttggcgtcgaatttacggcGatggatgtgactgggccgga	16	8	0	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr15:90451602G>A	uc002bos.3	-	3	366	c.211C>T	c.(211-213)CGC>TGC	p.R71C	C15orf38_uc002bot.1_RNA|C15orf38_uc002bou.2_Missense_Mutation_p.R71C	NM_182616	NP_872422	P59780	AP3S2_HUMAN	hypothetical protein LOC348110	Error:Variant_position_missing_in_P59780_after_alignment					intracellular protein transport|vesicle-mediated transport	cytoplasmic vesicle membrane|Golgi apparatus|membrane coat	protein transporter activity				0	Lung NSC(78;0.0181)|all_lung(78;0.0384)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.223)			AATTTACGGCGATGGATGTGA	0.567													A	90451602	A	A	90451602	3	1	21	1	0	0	0	0	1	0	0	0	750	1058	37	2		2	AP3S2	15	90451602	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	130274	90451602	12079790	41	1337											
PLCG2	5336	broad.mit.edu	37	chr16	81944227	81944227	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttcagcagcatctatgcCctcatccagcactaccgcga	6	17	3	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr16:81944227C>T	uc002fgt.2	+	18	1988	c.1836C>T	c.(1834-1836)GCC>GCT	p.A612A	PLCG2_uc010chg.1_Silent_p.A612A	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	612	SH2 1.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						GCATCTATGCCCTCATCCAGC	0.642													T	81944227	T	T	81944227	2	4	21	1	0	0	0	0	0	0	0	1	12036	610	22	3		3	PLCG2	16	81944227	Silent	SNP	C	TCGA-06-0142-01A-01D-1490-08		81944227	8410526	42	1338											
DNAH2	146754	broad.mit.edu	37	chr17	7668816	7668816	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggagaaattcaagacaggCctgatccactcggcagatga	11	9	1	5			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr17:7668816C>T	uc002giu.1	+	20	3458	c.3444C>T	c.(3442-3444)GGC>GGT	p.G1148G		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1148	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCAAGACAGGCCTGATCCACT	0.463													T	7668816	T	T	7668816	2	4	21	1	0	0	0	0	0	0	0	1	4602	726	26	3		3	DNAH2	17	7668816	Silent	SNP	C	TCGA-06-0142-01A-01D-1490-08		7668816	73526394	43	1339											
MYH4	4622	broad.mit.edu	37	chr17	10352234	10352234	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgcaggcagcattagatcGttccacatcaatcatgaggt	9	9	2	2			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr17:10352234G>A	uc002gmn.2	-	31	4423	c.4312C>T	c.(4312-4314)CGA>TGA	p.R1438*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1438	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GCATTAGATCGTTCCACATCA	0.438													A	10352234	A	A	10352234	4	1	21	1	0	0	0	0	0	1	0	0	10037	1153	40	1	1547	1	MYH4	17	10352234	Nonsense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	2683418	10352234	70842976	44	1340											
DDX5	1655	broad.mit.edu	37	chr17	62500099	62500102	+	Splice_Site	DEL	ACAG	-	-													tcaagagttctcccaaacttAcagacaatgttttcccagat							TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr17:62500099_62500102delACAG	uc002jek.2	-	4	688	c.441_splice	c.e4+1	p.S147_splice	DDX5_uc010deh.2_Splice_Site_p.S147_splice|DDX5_uc002jej.2_Splice_Site_p.S42_splice|DDX5_uc010wqa.1_Intron|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5						cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			TCCCAAACTTACAGACAATGTTTT	0.397			T	ETV4	prostate								-	62500102	-	-	62500099	8	5	21	1	0	1	0	1	0	0	1	0	4367	405	14	0	1441	0	DDX5	17	62500099	Splice_Site	DEL	ACAG	TCGA-06-0142-01A-01D-1490-08	52147865	62500099	18695111	45	1341											
CPAMD8	27151	broad.mit.edu	37	chr19	17122460	17122460	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atgaatacagaagcgccccgGccgtccacggtcaccgaggt	12	14	1	2			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr19:17122460G>T	uc002nfb.2	-	4	548	c.516C>A	c.(514-516)GGC>GGA	p.G172G		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	125						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						AAGCGCCCCGGCCGTCCACGG	0.672													T	17122460	T	T	17122460	2	4	21	1	0	0	0	0	0	0	0	1	3795	1190	42	5		5	CPAMD8	19	17122460	Silent	SNP	G	TCGA-06-0142-01A-01D-1490-08		17122460	42006523	46	1342											
ZNF626	199777	broad.mit.edu	37	chr19	20807475	20807475	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggagtacttaaaagctttgCcacattcttcacatttgtag	7	8	2	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr19:20807475C>G	uc002npb.1	-	4	1358	c.1208G>C	c.(1207-1209)GGC>GCC	p.G403A	ZNF626_uc002npc.1_Missense_Mutation_p.G327A	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	403	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						AAAAGCTTTGCCACATTCTTC	0.398													G	20807475	G	G	20807475	3	3	21	1	0	0	0	0	1	0	0	0	18047	739	26	5	382	5	ZNF626	19	20807475	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	3685015	20807475	38321508	47	1343											
PRODH2	58510	broad.mit.edu	37	chr19	36303630	36303630	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccttaaggtggaaggccccGccatcaaagctcagggactg	12	13	2	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr19:36303630G>A	uc002obx.1	-	2	324	c.306C>T	c.(304-306)GGC>GGT	p.G102G		NM_021232	NP_067055	Q9UF12	PROD2_HUMAN	kidney and liver proline oxidase 1	102					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			ovary(2)	2	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGAAGGCCCCGCCATCAAAGC	0.652													A	36303630	A	A	36303630	2	1	21	1	0	0	0	0	0	0	0	1	12549	1074	38	1		1	PRODH2	19	36303630	Silent	SNP	G	TCGA-06-0142-01A-01D-1490-08	15496155	36303630	22825353	48	1344											
PSG1	5669	broad.mit.edu	37	chr19	43376102	43376102	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catccaccacaggtagcttgCgtctggagtctcagggtcac	11	13	3	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr19:43376102C>T	uc002ovb.2	-	3	664	c.526G>A	c.(526-528)GCA>ACA	p.A176T	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.A176T|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.A176T|PSG1_uc010eio.1_Missense_Mutation_p.A176T|PSG1_uc002oux.1_Missense_Mutation_p.A105T|PSG1_uc002ouy.1_Missense_Mutation_p.A176T|PSG1_uc002ouz.1_Missense_Mutation_p.A176T|PSG1_uc002ova.1_Intron|PSG1_uc002ovc.2_Intron|PSG1_uc002ovd.1_Missense_Mutation_p.A176T	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	176	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				AGGTAGCTTGCGTCTGGAGTC	0.527													T	43376102	T	T	43376102	3	4	21	1	0	0	0	0	1	0	0	0	12653	768	27	1	802	1	PSG1	19	43376102	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	7072472	43376102	15752881	49	1345											
ZNF8	7554	broad.mit.edu	37	chr19	58806753	58806753	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagaaagagctctgcaggcGgagcaaaggcagggcagccg	16	11	1	2			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr19:58806753G>A	uc002qry.1	+	4	1709	c.1579G>A	c.(1579-1581)GGA>AGA	p.G527R	ZNF8_uc002qrz.2_RNA	NM_021089	NP_066575	P17098	ZNF8_HUMAN	zinc finger protein 8	527					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		CTCTGCAGGCGGAGCAAAGGC	0.557													A	58806753	A	A	58806753	3	1	21	1	0	0	0	0	1	0	0	0	18164	1117	39	2	1593	2	ZNF8	19	58806753	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08	15430651	58806753	322230	50	1346											
GTSF1L	149699	broad.mit.edu	37	chr20	42355070	42355070	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgagacctgctgggtgtcatCgttctgctctgaactaggag	13	9	3	2	rs143516837	byFrequency	TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr20:42355070C>T	uc002xld.2	-	1	573	c.265G>A	c.(265-267)GAT>AAT	p.D89N	GTSF1L_uc002xlc.2_Missense_Mutation_p.D89N	NM_176791	NP_789761	Q9H1H1	GTSFL_HUMAN	gametocyte specific factor 1-like isoform 1	89							metal ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TGGGTGTCATCGTTCTGCTCT	0.517													T	42355070	T	T	42355070	3	4	21	1	0	0	0	0	1	0	0	0	6887	884	31	2	185	2	GTSF1L	20	42355070	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08		42355070	20670450	51	1347											
SPINLW1	57119	broad.mit.edu	37	chr20	44171338	44171338	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accggggcccctaggacttaCgtttattcttgcaggtgttc	11	11	1	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr20:44171338C>T	uc002xou.2	-	3	423	c.391_splice	c.e3+1	p.R131_splice	SPINLW1_uc010zxc.1_Splice_Site_p.Q131_splice|SPINLW1_uc002xot.2_Splice_Site_p.R115_splice|SPINLW1_uc002xov.1_3'UTR	NM_020398	NP_065131	O95925	EPPI_HUMAN	serine peptidase inhibitor-like, with Kunitz and							extracellular region	serine-type endopeptidase inhibitor activity			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)				CTAGGACTTACGTTTATTCTT	0.507													T	44171338	T	T	44171338	5	4	21	1	0	0	0	0	0	0	1	0	15066	550	19	1	17	1	SPINLW1	20	44171338	Splice_Site	SNP	C	TCGA-06-0142-01A-01D-1490-08	1816268	44171338	18854182	52	1348											
COL6A2	1292	broad.mit.edu	37	chr21	47537831	47537831	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agcagggagtccaggggagcGaggagaccaaggcggcaagg	20	8	0	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr21:47537831G>A	uc002zia.1	+	12	1179	c.1097G>A	c.(1096-1098)CGA>CAA	p.R366Q	COL6A2_uc002zhy.1_Missense_Mutation_p.R366Q|COL6A2_uc002zhz.1_Missense_Mutation_p.R366Q|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	366	Triple-helical region.|Cell attachment site (Potential).				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCAGGGGAGCGAGGAGACCAA	0.682													A	47537831	A	A	47537831	3	1	21	1	0	0	0	0	1	0	0	0	3700	1058	37	2	1139	2	COL6A2	21	47537831	Missense_Mutation	SNP	G	TCGA-06-0142-01A-01D-1490-08		47537831	592064	53	1349											
EMID1	129080	broad.mit.edu	37	chr22	29621149	29621149	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcctctgcctccttggagcCcatgtggtcgggcagtacca	11	14	1	0			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr22:29621149C>T	uc003aen.2	+	4	416	c.341C>T	c.(340-342)CCC>CTC	p.P114L	EMID1_uc003aem.2_Missense_Mutation_p.P116L|EMID1_uc003aeo.2_Missense_Mutation_p.P116L|EMID1_uc003aep.2_Missense_Mutation_p.P116L	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	EMI domain containing 1	114						collagen					0						TCCTTGGAGCCCATGTGGTCG	0.637													T	29621149	T	T	29621149	3	4	21	1	0	0	0	0	1	0	0	0	5091	623	22	3	361	3	EMID1	22	29621149	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08		29621149	21683417	54	1350											
SFI1	9814	broad.mit.edu	37	chr22	31985517	31985517	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaacagactctggcgatggCgccaccaggaaaatgtcctc	12	12	1	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chr22:31985517C>T	uc003ale.2	+	15	1891	c.1498C>T	c.(1498-1500)CGC>TGC	p.R500C	SFI1_uc003ald.1_Missense_Mutation_p.R476C|SFI1_uc003alf.2_Missense_Mutation_p.R469C|SFI1_uc003alg.2_Missense_Mutation_p.R418C|SFI1_uc011alp.1_Missense_Mutation_p.R418C|SFI1_uc011alq.1_Missense_Mutation_p.R445C|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	500					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						CTGGCGATGGCGCCACCAGGA	0.532													T	31985517	T	T	31985517	3	4	21	1	0	0	0	0	1	0	0	0	14156	768	27	1	1552	1	SFI1	22	31985517	Missense_Mutation	SNP	C	TCGA-06-0142-01A-01D-1490-08	2364368	31985517	19319049	55	1351											
MTMR8	55613	broad.mit.edu	37	chrX	63569901	63569901	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aacttccaaccaccgttcccAaggtaacagatttaggaacc	6	13	0	1			TCGA-06-0142-01A-01D-1490-08	TCGA-06-0142-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	4bce79ce-c59c-4d86-b25f-28c8edda1651	6fe9d3fc-aebc-4e05-8eb2-c5fd4f2bc0c2	g.chrX:63569901A>C	uc004dvs.2	-	5	586	c.518T>G	c.(517-519)TTG>TGG	p.L173W	MTMR8_uc011mou.1_Missense_Mutation_p.L173W|MTMR8_uc004dvt.1_Missense_Mutation_p.L173W	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	173	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						CACCGTTCCCAAGGTAACAGA	0.343													C	63569901	C	C	63569901	3	2	21	1	0	0	0	0	1	0	0	0	9949	131	5	5	1636	5	MTMR8	23	63569901	Missense_Mutation	SNP	A	TCGA-06-0142-01A-01D-1490-08		63569901	91700659	56	1352											
CAMTA1	23261	broad.mit.edu	37	chr1	7798426	7798426	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccttcacaggtgcgtccaCgggaaccaatgagtgtcctg	11	13	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr1:7798426C>T	uc001aoi.2	+	16	4273	c.4066C>T	c.(4066-4068)CGG>TGG	p.R1356W	CAMTA1_uc010nzv.1_Missense_Mutation_p.R443W|CAMTA1_uc001aok.3_Missense_Mutation_p.R399W|CAMTA1_uc001aoj.2_Missense_Mutation_p.R312W	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GGTGCGTCCACGGGAACCAAT	0.512													T	7798426	T	T	7798426	3	4	22	1	0	0	0	0	1	0	0	0	2613	527	19	1	4128	1	CAMTA1	1	7798426	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08		7798426	241452195	1	1353											
PADI3	51702	broad.mit.edu	37	chr1	17575699	17575699	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcggtgtgtgtggctggcGtggagaccctcgtggacatt	18	9	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr1:17575699G>A	uc001bai.2	+	1	107	c.67G>A	c.(67-69)GTG>ATG	p.V23M		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	23					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TGTGGCTGGCGTGGAGACCCT	0.617													A	17575699	A	A	17575699	3	1	22	1	0	0	0	0	1	0	0	0	11379	1145	40	1	69	1	PADI3	1	17575699	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	9777273	17575699	231674922	2	1354											
GRHL3	57822	broad.mit.edu	37	chr1	24663202	24663202	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtggacagctacctgttacCcaccactgatatgtatgata	8	10	0	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr1:24663202C>T	uc001biy.2	+	4	558	c.512C>T	c.(511-513)CCC>CTC	p.P171L	GRHL3_uc001bix.2_Missense_Mutation_p.P166L|GRHL3_uc001biz.2_Missense_Mutation_p.P73L	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	166					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		TACCTGTTACCCACCACTGAT	0.602													T	24663202	T	T	24663202	3	4	22	1	0	0	0	0	1	0	0	0	6765	623	22	3	547	3	GRHL3	1	24663202	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	7087503	24663202	224587419	3	1355											
MCOLN3	55283	broad.mit.edu	37	chr1	85499910	85499910	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcataagcatgattcccaaCggagacattgtatagctgca	8	10	1	2	rs144793042	byFrequency	TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr1:85499910C>T	uc001dkp.2	-	4	514	c.421G>A	c.(421-423)GTT>ATT	p.V141I	MCOLN3_uc001dkq.2_Missense_Mutation_p.V85I|MCOLN3_uc001dkr.2_Missense_Mutation_p.V141I|MCOLN3_uc001dks.3_5'UTR	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	141						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		TGATTCCCAACGGAGACATTG	0.468													T	85499910	T	T	85499910	3	4	22	1	0	0	0	0	1	0	0	0	9397	536	19	1	1280	1	MCOLN3	1	85499910	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	60836708	85499910	163750711	4	1356											
RGL1	23179	broad.mit.edu	37	chr1	183895313	183895313	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	actttgacttcattttgcgcAaaaagaactccatggaagaa	7	8	1	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr1:183895313A>T	uc001gqo.2	+	18	2351	c.2194A>T	c.(2194-2196)AAA>TAA	p.K732*	RGL1_uc001gqm.2_Nonsense_Mutation_p.K767*|RGL1_uc010pog.1_Nonsense_Mutation_p.K730*|RGL1_uc010poh.1_Nonsense_Mutation_p.K730*|RGL1_uc010poi.1_Nonsense_Mutation_p.K703*	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	732	Ras-associating.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						CATTTTGCGCAAAAAGAACTC	0.443													T	183895313	T	T	183895313	4	4	22	1	0	0	0	0	0	1	0	0	13276	131	5	5	2369	5	RGL1	1	183895313	Nonsense_Mutation	SNP	A	TCGA-06-0145-01A-01W-0224-08	98395403	183895313	65355308	5	1357											
DISP1	84976	broad.mit.edu	37	chr1	223116326	223116326	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aacaaaagtgagtccaaatgGatgcctgcaacttaatggca	9	8	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr1:223116326G>A	uc001hnu.1	+	2	308	c.161G>A	c.(160-162)GGA>GAA	p.G54E		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	54					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AGTCCAAATGGATGCCTGCAA	0.507													A	223116326	A	A	223116326	3	1	22	1	0	0	0	0	1	0	0	0	4539	1174	41	3	163	3	DISP1	1	223116326	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	39221013	223116326	26134295	6	1358											
RYR2	6262	broad.mit.edu	37	chr1	237780709	237780709	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aacgtttccgatacaacgaaGtcatgcaagccttaaacatg	7	10	1	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr1:237780709G>C	uc001hyl.1	+	38	5959	c.5839G>C	c.(5839-5841)GTC>CTC	p.V1947L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1947	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATACAACGAAGTCATGCAAGC	0.448													C	237780709	C	C	237780709	3	2	22	1	0	0	0	0	1	0	0	0	13769	1029	36	5	5989	5	RYR2	1	237780709	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	14664383	237780709	11469912	7	1359											
RYR2	6262	broad.mit.edu	37	chr1	237863752	237863752	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atattggccagcatcagttcGgagaagacctaatatgtatg	10	7	1	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr1:237863752G>A	uc001hyl.1	+	65	9472	c.9352G>A	c.(9352-9354)GGA>AGA	p.G3118R	RYR2_uc010pxz.1_Missense_Mutation_p.G73R	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3118					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCATCAGTTCGGAGAAGACCT	0.373													A	237863752	A	A	237863752	3	1	22	1	0	0	0	0	1	0	0	0	13769	1117	39	2	9610	2	RYR2	1	237863752	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	83043	237863752	11386869	8	1360											
C2orf78	388960	broad.mit.edu	37	chr2	74040759	74040759	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	catggctacagccatcagccTctggcacctccttccagcca	7	18	2	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr2:74040759T>A	uc002sjr.1	+	2	374	c.253T>A	c.(253-255)TCT>ACT	p.S85T		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	85	Ser-rich.									ovary(2)	2						GCCATCAGCCTCTGGCACCTC	0.527													A	74040759	A	A	74040759	3	1	22	1	0	0	0	0	1	0	0	0	2195	1551	54	5	259	5	C2orf78	2	74040759	Missense_Mutation	SNP	T	TCGA-06-0145-01A-01W-0224-08		74040759	169158614	9	1361											
EDAR	10913	broad.mit.edu	37	chr2	109526984	109526984	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcggagaacatcaccacGttgtctgcagggaaatgggg	13	9	3	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr2:109526984G>A	uc002teq.3	-	9	1166	c.735C>T	c.(733-735)AAC>AAT	p.N245N	EDAR_uc010fjn.2_Silent_p.N277N|EDAR_uc010yws.1_Silent_p.N277N	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	245	Cytoplasmic (Potential).				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1						ACATCACCACGTTGTCTGCAG	0.552													A	109526984	A	A	109526984	2	1	22	1	0	0	0	0	0	0	0	1	4905	1136	40	1		1	EDAR	2	109526984	Silent	SNP	G	TCGA-06-0145-01A-01W-0224-08	35486225	109526984	133672389	10	1362											
PCDP1	200373	broad.mit.edu	37	chr2	120385326	120385326	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaggtgctgcccttcgctttCccagactgcagcccacccca	9	18	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr2:120385326C>T	uc002tmb.2	+	17	1848	c.756C>T	c.(754-756)TTC>TTT	p.F252F	PCDP1_uc010yyq.1_Silent_p.F382F	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	538						cilium	calmodulin binding				0	Colorectal(110;0.196)					CCTTCGCTTTCCCAGACTGCA	0.557													T	120385326	T	T	120385326	2	4	22	1	0	0	0	0	0	0	0	1	11572	854	30	3		3	PCDP1	2	120385326	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	10858342	120385326	122814047	11	1363											
POTEE	445582	broad.mit.edu	37	chr2	131976471	131976471	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatgctcagggacactgacGtgaacaagaaggacaagcaa	11	9	2	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr2:131976471G>A	uc002tsn.2	+	1	548	c.496G>A	c.(496-498)GTG>ATG	p.V166M	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Translation_Start_Site|POTEE_uc002tsl.2_Translation_Start_Site	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	166							ATP binding				0						GGACACTGACGTGAACAAGAA	0.592													A	131976471	A	A	131976471	3	1	22	1	0	0	0	0	1	0	0	0	12264	1145	40	1	498	1	POTEE	2	131976471	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	11591145	131976471	111222902	12	1364											
THSD7B	80731	broad.mit.edu	37	chr2	137814211	137814211	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtgtgcttgttccttacgctCgcggtgaagtcaagcctcgg	13	11	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr2:137814211C>T	uc002tva.1	+	2	268	c.268C>T	c.(268-270)CGC>TGC	p.R90C	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TCCTTACGCTCGCGGTGAAGT	0.542													T	137814211	T	T	137814211	3	4	22	1	0	0	0	0	1	0	0	0	15877	884	31	2	274	2	THSD7B	2	137814211	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	5837740	137814211	105385162	13	1365											
XIRP2	129446	broad.mit.edu	37	chr2	168101563	168101563	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctagttcagaggaagttttgAaaaagatcaaaaccttaaaa	7	5	2	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr2:168101563A>G	uc002udx.2	+	8	3679	c.3661A>G	c.(3661-3663)AAA>GAA	p.K1221E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.K1046E|XIRP2_uc010fpq.2_Missense_Mutation_p.K999E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1046					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GGAAGTTTTGAAAAAGATCAA	0.308													G	168101563	G	G	168101563	3	3	22	1	0	0	0	0	1	0	0	0	17427	247	9	4	3691	4	XIRP2	2	168101563	Missense_Mutation	SNP	A	TCGA-06-0145-01A-01W-0224-08	30287352	168101563	75097810	14	1366											
TTN	7273	broad.mit.edu	37	chr2	179469622	179469622	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatttcttggtggggatgggCggtctggaaaggaatcaaca	16	5	3	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr2:179469622C>T	uc010zfg.1	-	230	46714	c.46490G>A	c.(46489-46491)CGC>CAC	p.R15497H	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R9192H|TTN_uc010zfi.1_Missense_Mutation_p.R9125H|TTN_uc010zfj.1_Missense_Mutation_p.R9000H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16424							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGGGATGGGCGGTCTGGAAA	0.418													T	179469622	T	T	179469622	3	4	22	1	0	0	0	0	1	0	0	0	16732	768	27	1	53827	1	TTN	2	179469622	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	11368059	179469622	63729751	15	1367											
UGT1A5	54579	broad.mit.edu	37	chr2	234621856	234621856	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtacatcaaagaagagaaCtttttcaccctgacaacgta	6	9	2	3	rs17874940		TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr2:234621856C>T	uc002vuw.2	+	1	219	c.219C>T	c.(217-219)AAC>AAT	p.N73N	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Silent_p.N73N	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	73					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		AAGAAGAGAACTTTTTCACCC	0.512													T	234621856	T	T	234621856	2	4	22	1	0	0	0	0	0	0	0	1	16945	564	20	3		3	UGT1A5	2	234621856	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	55152234	234621856	8577517	16	1368											
GRM7	2917	broad.mit.edu	37	chr3	6903093	6903093	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agcatggtccagctgaggaaGctgctccgcgtcctgacttt	12	12	0	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr3:6903093G>T	uc003bqm.2	+	1	292	c.18G>T	c.(16-18)AAG>AAT	p.K6N	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.K6N|GRM7_uc003bql.2_Missense_Mutation_p.K6N	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	6					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	AGCTGAGGAAGCTGCTCCGCG	0.721													T	6903093	T	T	6903093	3	4	22	1	0	0	0	0	1	0	0	0	6802	962	34	5	20	5	GRM7	3	6903093	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08		6903093	191119337	17	1369											
PRKCD	5580	broad.mit.edu	37	chr3	53213676	53213676	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgcccacatctatgaggggCgcgtcatccagattgtgcta	11	11	2	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr3:53213676C>T	uc003dgl.2	+	4	552	c.199C>T	c.(199-201)CGC>TGC	p.R67C	PRKCD_uc003dgm.2_Missense_Mutation_p.R67C|PRKCD_uc003dgn.2_Missense_Mutation_p.R67C	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	67	C2.	Interaction with phosphotyrosine- containing peptide.			activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding	p.R67C(1)		central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		CTATGAGGGGCGCGTCATCCA	0.582													T	53213676	T	T	53213676	3	4	22	1	0	0	0	0	1	0	0	0	12509	768	27	1	205	1	PRKCD	3	53213676	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	46310583	53213676	144808754	18	1370											
ST6GAL1	6480	broad.mit.edu	37	chr3	186791960	186791960	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttcagtggtaccagaatcCggattataatttctttaaca	6	7	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr3:186791960C>T	uc003frb.2	+	7	1250	c.818C>T	c.(817-819)CCG>CTG	p.P273L	ST6GAL1_uc003frc.2_Missense_Mutation_p.P42L|ST6GAL1_uc003frd.2_Missense_Mutation_p.P273L	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	273	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity	p.P273L(1)		central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		TACCAGAATCCGGATTATAAT	0.488													T	186791960	T	T	186791960	3	4	22	1	0	0	0	0	1	0	0	0	15220	652	23	2	832	2	ST6GAL1	3	186791960	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	133578284	186791960	11230470	19	1371											
UGT2A1	10941	broad.mit.edu	37	chr4	70455275	70455275	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcttggctcctttgtggcGcatgacaaactcgatccaga	11	11	0	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr4:70455275G>A	uc003hem.3	-	6	1462	c.1399C>T	c.(1399-1401)CGC>TGC	p.R467C	UGT2A1_uc011caq.1_Missense_Mutation_p.R633C|UGT2A1_uc010ihu.2_Missense_Mutation_p.R467C|UGT2A1_uc010iht.2_Missense_Mutation_p.R423C|UGT2A1_uc010ihs.2_Missense_Mutation_p.R468C	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	467	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						CCTTTGTGGCGCATGACAAAC	0.478													A	70455275	A	A	70455275	3	1	22	1	0	0	0	0	1	0	0	0	16950	1087	38	1	188	1	UGT2A1	4	70455275	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08		70455275	120699001	20	1372											
FRAS1	80144	broad.mit.edu	37	chr4	79362349	79362349	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggagagcaccactctcatttCaccatttttttgctactgat	6	11	2	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr4:79362349C>A	uc003hlb.2	+	41	6003	c.5563C>A	c.(5563-5565)CAC>AAC	p.H1855N	FRAS1_uc003hkw.2_Missense_Mutation_p.H1855N|FRAS1_uc010ijj.1_Missense_Mutation_p.H275N	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1854	CSPG 7.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACTCTCATTTCACCATTTTTT	0.418													A	79362349	A	A	79362349	3	1	22	1	0	0	0	0	1	0	0	0	6042	826	29	5	5725	5	FRAS1	4	79362349	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	8907074	79362349	111791927	21	1373											
OSTC	58505	broad.mit.edu	37	chr4	109571929	109571929	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtatgctctggtggtggtgTcttacttcctcatcaccgga	11	10	4	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr4:109571929T>C	uc003hzb.1	+	1	189	c.118T>C	c.(118-120)TCT>CCT	p.S40P		NM_021227	NP_067050	Q9NRP0	OSTC_HUMAN	DC2 protein	40	Helical; (Potential).					integral to membrane|oligosaccharyltransferase complex				breast(1)	1						GGTGGTGGTGTCTTACTTCCT	0.612													C	109571929	C	C	109571929	3	2	22	1	0	0	0	0	1	0	0	0	11296	1667	58	4	120	4	OSTC	4	109571929	Missense_Mutation	SNP	T	TCGA-06-0145-01A-01W-0224-08	30209580	109571929	81582347	22	1374											
DCHS2	54798	broad.mit.edu	37	chr4	155226289	155226289	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaatttctctgtcaagtatGgtggttgtcactacctctcc	8	10	4	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr4:155226289G>A	uc003inw.2	-	16	3990	c.3990C>T	c.(3988-3990)ACC>ACT	p.T1330T		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1330	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TGTCAAGTATGGTGGTTGTCA	0.343													A	155226289	A	A	155226289	2	1	22	1	0	0	0	0	0	0	0	1	4288	1335	47	3		3	DCHS2	4	155226289	Silent	SNP	G	TCGA-06-0145-01A-01W-0224-08	45654360	155226289	35927987	23	1375											
TKTL2	84076	broad.mit.edu	37	chr4	164393803	164393803	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aataatacactctatgaaacGctcagggtgttctttcctga	7	9	3	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr4:164393803G>A	uc003iqp.3	-	1	1245	c.1084C>T	c.(1084-1086)CGT>TGT	p.R362C		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	362						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCTATGAAACGCTCAGGGTGT	0.368													A	164393803	A	A	164393803	3	1	22	1	0	0	0	0	1	0	0	0	15933	1087	38	1	800	1	TKTL2	4	164393803	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	9167514	164393803	26760473	24	1376											
IRF2	3660	broad.mit.edu	37	chr4	185329382	185329382	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accgcatactcaggagaaagAtcacttactccattactaag	6	11	2	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr4:185329382A>G	uc003iwf.3	-	6	659	c.459T>C	c.(457-459)GAT>GAC	p.D153D		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	153					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		CAGGAGAAAGATCACTTACTC	0.388													G	185329382	G	G	185329382	2	3	22	1	0	0	0	0	0	0	0	1	7828	330	12	4		4	IRF2	4	185329382	Silent	SNP	A	TCGA-06-0145-01A-01W-0224-08	20935579	185329382	5824894	25	1377											
TERT	7015	broad.mit.edu	37	chr5	1280302	1280302	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctgcggaacgttctggctcCcacgacgtagtccatgttca	10	13	3	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr5:1280302C>A	uc003jcb.1	-	4	1979	c.1921G>T	c.(1921-1923)GGA>TGA	p.G641*	TERT_uc003jbz.1_5'UTR|TERT_uc003jca.1_Nonsense_Mutation_p.G641*|TERT_uc003jcc.1_Nonsense_Mutation_p.G641*|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	641	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GTTCTGGCTCCCACGACGTAG	0.557									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				A	1280302	A	A	1280302	4	1	22	1	0	0	0	0	0	1	0	0	15761	632	22	5	1529	5	TERT	5	1280302	Nonsense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08		1280302	179634958	26	1378											
SLC6A3	6531	broad.mit.edu	37	chr5	1422128	1422128	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggaggtgcagcacgccacGtctgcagaggggagtcagcg	18	10	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr5:1422128G>A	uc003jck.2	-	5	776	c.655C>T	c.(655-657)CGT>TGT	p.R219C		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	219	Extracellular (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGCACGCCACGTCTGCAGAGG	0.667													A	1422128	A	A	1422128	3	1	22	1	0	0	0	0	1	0	0	0	14685	1159	40	1	1251	1	SLC6A3	5	1422128	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	141826	1422128	179493132	27	1379											
PCDHA1	56147	broad.mit.edu	37	chr5	140166017	140166017	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acggcaccttcgttggccgcGttgctcaggacctgggactg	14	13	1	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr5:140166017G>A	uc003lhb.2	+	1	142	c.142G>A	c.(142-144)GTT>ATT	p.V48I	PCDHA1_uc003lha.2_Missense_Mutation_p.V48I|PCDHA1_uc003lgz.2_Missense_Mutation_p.V48I	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	48	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTTGGCCGCGTTGCTCAGGA	0.627													A	140166017	A	A	140166017	3	1	22	1	0	0	0	0	1	0	0	0	11519	1145	40	1	144	1	PCDHA1	5	140166017	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	138743889	140166017	40749243	28	1380											
FAT2	2196	broad.mit.edu	37	chr5	150924338	150924338	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccccaagataggggtcaattCggaaatatgtgtaatcttct	9	8	3	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr5:150924338C>T	uc003lue.3	-	9	6363	c.6350G>A	c.(6349-6351)CGA>CAA	p.R2117Q	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2117	Extracellular (Potential).|Cadherin 18.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGGTCAATTCGGAAATATGT	0.433													T	150924338	T	T	150924338	3	4	22	1	0	0	0	0	1	0	0	0	5690	884	31	2	6759	2	FAT2	5	150924338	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	10758321	150924338	29990922	29	1381											
GABRA1	2554	broad.mit.edu	37	chr5	161318009	161318009	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gacagtgattctctcacaagTctccttctggctcaacagag	8	12	5	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr5:161318009T>C	uc010jiw.2	+	9	1277	c.809T>C	c.(808-810)GTC>GCC	p.V270A	GABRA1_uc010jix.2_Missense_Mutation_p.V270A|GABRA1_uc010jiy.2_Missense_Mutation_p.V270A|GABRA1_uc003lyx.3_Missense_Mutation_p.V270A|GABRA1_uc010jiz.2_Missense_Mutation_p.V270A|GABRA1_uc010jja.2_Missense_Mutation_p.V270A|GABRA1_uc010jjb.2_Missense_Mutation_p.V270A	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	270	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CTCTCACAAGTCTCCTTCTGG	0.408													C	161318009	C	C	161318009	3	2	22	1	0	0	0	0	1	0	0	0	6160	1667	58	4	835	4	GABRA1	5	161318009	Missense_Mutation	SNP	T	TCGA-06-0145-01A-01W-0224-08	10393671	161318009	19597251	30	1382											
TAP1	6890	broad.mit.edu	37	chr6	32815851	32815851	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgccgtcacctcgccagggcGtagggtgaatgtcagcccct	13	15	2	1	rs149070070	byFrequency	TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr6:32815851G>A	uc003ocg.2	-	8	1920	c.1765C>T	c.(1765-1767)CGC>TGC	p.R589C	TAP1_uc011dqi.1_Missense_Mutation_p.R328C	NM_000593	NP_000584	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family	589	Cytoplasmic (Potential).|ABC transporter.				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1						TCGCCAGGGCGTAGGGTGAAT	0.582													A	32815851	A	A	32815851	3	1	22	1	0	0	0	0	1	0	0	0	15547	1145	40	1	677	1	TAP1	6	32815851	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08		32815851	138299216	31	1383											
RUNX2	860	broad.mit.edu	37	chr6	45514681	45514681	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccacctttacttacacccCgccagtcacctcaggcatgt	6	17	2	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr6:45514681C>T	uc011dvx.1	+	9	1415	c.1205C>T	c.(1204-1206)CCG>CTG	p.P402L	RUNX2_uc011dvy.1_Missense_Mutation_p.P380L|RUNX2_uc003oxt.2_Missense_Mutation_p.P388L	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	402	Interaction with MYST3 (By similarity).|Pro/Ser/Thr-rich.|Interaction with MYST4.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						ACTTACACCCCGCCAGTCACC	0.577													T	45514681	T	T	45514681	3	4	22	1	0	0	0	0	1	0	0	0	13748	652	23	2	1251	2	RUNX2	6	45514681	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	12698830	45514681	125600386	32	1384											
ZNF292	23036	broad.mit.edu	37	chr6	87969728	87969728	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctttgctgcctttacgatAcagcaaaacttgattctcca	6	11	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr6:87969728A>G	uc003plm.3	+	8	6422	c.6381A>G	c.(6379-6381)ATA>ATG	p.I2127M		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2127	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CCTTTACGATACAGCAAAACT	0.438													G	87969728	G	G	87969728	3	3	22	1	0	0	0	0	1	0	0	0	17823	381	14	4	6411	4	ZNF292	6	87969728	Missense_Mutation	SNP	A	TCGA-06-0145-01A-01W-0224-08	42455047	87969728	83145339	33	1385											
LAMA2	3908	broad.mit.edu	37	chr6	129371228	129371228	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatcaaaacagcagcaatcCaaaccgtatgtattttagtg	6	9	1	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr6:129371228C>T	uc003qbn.2	+	2	383	c.278C>T	c.(277-279)CCA>CTA	p.P93L	LAMA2_uc003qbo.2_Missense_Mutation_p.P93L	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	93	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGCAGCAATCCAAACCGTATG	0.438													T	129371228	T	T	129371228	3	4	22	1	0	0	0	0	1	0	0	0	8606	594	21	3	284	3	LAMA2	6	129371228	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	41401500	129371228	41743839	34	1386											
GRM1	2911	broad.mit.edu	37	chr6	146720521	146720521	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgtgcccgccaacttcaaCgaggccaaatatatcgcgtt	8	13	1	0	rs145874853	byFrequency	TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr6:146720521C>T	uc010khw.1	+	8	2816	c.2346C>T	c.(2344-2346)AAC>AAT	p.N782N	GRM1_uc010khv.1_Silent_p.N782N|GRM1_uc003qll.2_Silent_p.N782N|GRM1_uc011edz.1_Silent_p.N782N|GRM1_uc011eea.1_Silent_p.N782N	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	782	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCAACTTCAACGAGGCCAAAT	0.502													T	146720521	T	T	146720521	2	4	22	1	0	0	0	0	0	0	0	1	6796	535	19	1		1	GRM1	6	146720521	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	17349293	146720521	24394546	35	1387											
GRM1	2911	broad.mit.edu	37	chr6	146755247	146755247	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggatgcccagccgattcGctttagcccgcctggtagcc	13	14	0	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr6:146755247G>A	uc010khw.1	+	9	3370	c.2900G>A	c.(2899-2901)CGC>CAC	p.R967H	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	967	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R967H(1)		lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CAGCCGATTCGCTTTAGCCCG	0.602													A	146755247	A	A	146755247	3	1	22	1	0	0	0	0	1	0	0	0	6796	1087	38	1	2995	1	GRM1	6	146755247	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	34726	146755247	24359820	36	1388											
C6orf211	79624	broad.mit.edu	37	chr6	151789616	151789616	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggaacatctttggtcattgCttagcaattgcaagaaaaca	8	7	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr6:151789616C>G	uc003qok.1	+	5	956	c.697C>G	c.(697-699)CTT>GTT	p.L233V	C6orf211_uc011ees.1_Missense_Mutation_p.L114V	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	233							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		TTGGTCATTGCTTAGCAATTG	0.328													G	151789616	G	G	151789616	3	3	22	1	0	0	0	0	1	0	0	0	2354	797	28	5	715	5	C6orf211	6	151789616	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	5034369	151789616	19325451	37	1389											
MYCT1	80177	broad.mit.edu	37	chr6	153043291	153043291	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacttcccacagtctgagccGtcctgactactggtccagta	8	15	1	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr6:153043291G>A	uc003qpd.3	+	2	619	c.611G>A	c.(610-612)CGT>CAT	p.R204H	MYCT1_uc010kjc.1_Missense_Mutation_p.R156H|MYCT1_uc003qpc.3_Missense_Mutation_p.R204H	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	204						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		AGTCTGAGCCGTCCTGACTAC	0.532													A	153043291	A	A	153043291	3	1	22	1	0	0	0	0	1	0	0	0	10022	1145	40	1	617	1	MYCT1	6	153043291	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	1253675	153043291	18071776	38	1390											
HDAC9	9734	broad.mit.edu	37	chr7	18788727	18788727	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatacagagtatctggtcacGactgcaagaaactgggctgc	11	9	2	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr7:18788727G>A	uc003suh.2	+	13	2041	c.2000G>A	c.(1999-2001)CGA>CAA	p.R667Q	HDAC9_uc003sue.2_Missense_Mutation_p.R667Q|HDAC9_uc011jyd.1_Missense_Mutation_p.R667Q|HDAC9_uc003sui.2_Missense_Mutation_p.R670Q|HDAC9_uc003suj.2_Missense_Mutation_p.R626Q|HDAC9_uc003sua.1_Missense_Mutation_p.R645Q|HDAC9_uc010kue.1_Missense_Mutation_p.R322Q	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	667	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	ATCTGGTCACGACTGCAAGAA	0.438													A	18788727	A	A	18788727	3	1	22	1	0	0	0	0	1	0	0	0	7014	1058	37	2	2110	2	HDAC9	7	18788727	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08		18788727	140349936	39	1391											
ZPBP	11055	broad.mit.edu	37	chr7	50097612	50097612	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcatattttagttgaagacGtttaacaatttcttccacag	6	7	1	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr7:50097612G>A	uc003tou.2	-	4	530	c.460C>T	c.(460-462)CGT>TGT	p.R154C	ZPBP_uc011kci.1_Missense_Mutation_p.R80C|ZPBP_uc010kyw.2_Missense_Mutation_p.R153C	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	154					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					AGTTGAAGACGTTTAACAATT	0.294													A	50097612	A	A	50097612	3	1	22	1	0	0	0	0	1	0	0	0	18216	1145	40	1	615	1	ZPBP	7	50097612	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	31308885	50097612	109041051	40	1392											
POM121L12	285877	broad.mit.edu	37	chr7	53103630	53103630	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacccaggaccccgccaagcCgcagcgggtggtctccgagg	14	17	1	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr7:53103630C>T	uc003tpz.2	+	1	282	c.266C>T	c.(265-267)CCG>CTG	p.P89L		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	89											0						CCCGCCAAGCCGCAGCGGGTG	0.692													T	53103630	T	T	53103630	3	4	22	1	0	0	0	0	1	0	0	0	12241	652	23	2	268	2	POM121L12	7	53103630	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	3006018	53103630	106035033	41	1393											
SEMA3C	10512	broad.mit.edu	37	chr7	80387693	80387693	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaggaatggccatcccaggCgcaataagggtcccgcgcca	12	14	0	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr7:80387693C>T	uc003uhj.2	-	15	2159	c.1597G>A	c.(1597-1599)GCC>ACC	p.A533T	SEMA3C_uc011kgw.1_Missense_Mutation_p.A551T	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	533					immune response|response to drug	membrane	receptor activity			ovary(1)	1						CCATCCCAGGCGCAATAAGGG	0.537													T	80387693	T	T	80387693	3	4	22	1	0	0	0	0	1	0	0	0	14026	768	27	1	674	1	SEMA3C	7	80387693	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	27284063	80387693	78750970	42	1394											
PDK4	5166	broad.mit.edu	37	chr7	95216404	95216404	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaagtactttgcatacagaCgagaaattggcaagccgtaa	10	7	0	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr7:95216404C>T	uc003uoa.2	-	10	1333	c.1013G>A	c.(1012-1014)CGT>CAT	p.R338H	PDK4_uc003unz.2_Missense_Mutation_p.R126H	NM_002612	NP_002603	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase 4 precursor	338	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity				0	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			TGCATACAGACGAGAAATTGG	0.378													T	95216404	T	T	95216404	3	4	22	1	0	0	0	0	1	0	0	0	11678	536	19	1	230	1	PDK4	7	95216404	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	14828711	95216404	63922259	43	1395											
KEL	3792	broad.mit.edu	37	chr7	142650962	142650962	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atattccacgtcatggaccaCgagggactgagaagggctca	12	10	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr7:142650962C>T	uc003wcb.2	-	9	1216	c.1006G>A	c.(1006-1008)GTG>ATG	p.V336M		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	336	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TCATGGACCACGAGGGACTGA	0.537													T	142650962	T	T	142650962	3	4	22	1	0	0	0	0	1	0	0	0	8142	536	19	1	1236	1	KEL	7	142650962	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	47434558	142650962	16487701	44	1396											
TRPA1	8989	broad.mit.edu	37	chr8	72938268	72938268	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gatccactttgcgtagaaacCaaagtggcagcttcttctct	8	11	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr8:72938268C>A	uc003xza.2	-	25	3153	c.2978G>T	c.(2977-2979)TGG>TTG	p.W993L	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	993	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GCGTAGAAACCAAAGTGGCAG	0.363													A	72938268	A	A	72938268	3	1	22	1	0	0	0	0	1	0	0	0	16574	595	21	5	393	5	TRPA1	8	72938268	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08		72938268	73425754	45	1397											
DOCK8	81704	broad.mit.edu	37	chr9	286581	286581	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcactgatgacgacttggacGtggtgttcacgccaaaggaa	12	9	2	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr9:286581G>A	uc003zgf.2	+	3	389	c.277G>A	c.(277-279)GTG>ATG	p.V93M	DOCK8_uc011lls.1_Missense_Mutation_p.V93M|DOCK8_uc010mgu.2_Translation_Start_Site|DOCK8_uc010mgv.2_Missense_Mutation_p.V25M|DOCK8_uc010mgt.2_Missense_Mutation_p.V25M|DOCK8_uc003zgg.2_Missense_Mutation_p.V25M|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	93					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity	p.V25M(1)		ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CGACTTGGACGTGGTGTTCAC	0.498													A	286581	A	A	286581	3	1	22	1	0	0	0	0	1	0	0	0	4693	1145	40	1	287	1	DOCK8	9	286581	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08		286581	140926850	46	1398											
GLIS3	169792	broad.mit.edu	37	chr9	4286000	4286000	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatgggggagaaaaaaatcGtttccatttttaaaaggttc	11	4	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr9:4286000G>A	uc003zii.1	-	2	1139	c.426C>T	c.(424-426)AAC>AAT	p.N142N	GLIS3_uc003zhx.1_Intron|GLIS3_uc003zic.1_Intron|GLIS3_uc003zie.1_Intron|GLIS3_uc010mhh.1_Intron|GLIS3_uc003zid.1_Intron|GLIS3_uc010mhi.1_Intron|GLIS3_uc003zif.1_Intron|GLIS3_uc003zig.1_Intron|GLIS3_uc003zih.1_Intron			Q8NEA6	GLIS3_HUMAN	SubName: Full=GLIS family zinc finger 3 transcript variant TS2; SubName: Full=GLIS family zinc finger 3 transcript variant TS3; SubName: Full=GLIS family zinc finger 3 transcript variant TS4; SubName: Full=GLIS family zinc finger 3 transcript variant TS5; Flags: Fragment;	Error:Variant_position_missing_in_Q8NEA6_after_alignment					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GAAAAAAATCGTTTCCATTTT	0.393													A	4286000	A	A	4286000	2	1	22	1	0	0	0	0	0	0	0	1	6447	1160	40	1		1	GLIS3	9	4286000	Silent	SNP	G	TCGA-06-0145-01A-01W-0224-08	3999419	4286000	136927431	47	1399											
PCDH15	65217	broad.mit.edu	37	chr10	55755492	55755492	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccatccctttgtatattcGtttactaaagacaggaggat	7	9	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr10:55755492G>A	uc001jju.1	-	21	3180	c.2785C>T	c.(2785-2787)CGA>TGA	p.R929*	PCDH15_uc010qhq.1_Nonsense_Mutation_p.R934*|PCDH15_uc010qhr.1_Nonsense_Mutation_p.R929*|PCDH15_uc010qhs.1_Nonsense_Mutation_p.R941*|PCDH15_uc010qht.1_Nonsense_Mutation_p.R936*|PCDH15_uc010qhu.1_Nonsense_Mutation_p.R929*|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Nonsense_Mutation_p.R929*|PCDH15_uc010qhw.1_Nonsense_Mutation_p.R892*|PCDH15_uc010qhx.1_Nonsense_Mutation_p.R858*|PCDH15_uc010qhy.1_Nonsense_Mutation_p.R934*|PCDH15_uc010qhz.1_Nonsense_Mutation_p.R929*|PCDH15_uc010qia.1_Nonsense_Mutation_p.R907*|PCDH15_uc010qib.1_Nonsense_Mutation_p.R907*|PCDH15_uc001jjw.2_Nonsense_Mutation_p.R929*	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	929	Extracellular (Potential).|Cadherin 9.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTGTATATTCGTTTACTAAAG	0.408										HNSCC(58;0.16)			A	55755492	A	A	55755492	4	1	22	1	0	0	0	0	0	1	0	0	11511	1153	40	1	4753	1	PCDH15	10	55755492	Nonsense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08		55755492	79779255	48	1400											
STAMBPL1	57559	broad.mit.edu	37	chr10	90665247	90665247	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acagatgtttccctaagcccAgaagagcgagtccgtgccct	10	13	0	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr10:90665247A>T	uc001kfk.2	+	3	501	c.78A>T	c.(76-78)CCA>CCT	p.P26P	STAMBPL1_uc010qmx.1_Silent_p.P26P|STAMBPL1_uc009xto.2_RNA|STAMBPL1_uc001kfl.2_Silent_p.P26P|STAMBPL1_uc001kfm.2_5'Flank	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	26							metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		CCCTAAGCCCAGAAGAGCGAG	0.418													T	90665247	T	T	90665247	2	4	22	1	0	0	0	0	0	0	0	1	15250	175	7	5		5	STAMBPL1	10	90665247	Silent	SNP	A	TCGA-06-0145-01A-01W-0224-08	34909755	90665247	44869500	49	1401											
OR51S1	119692	broad.mit.edu	37	chr11	4870156	4870156	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggacagtgtgagcaccagCaagggcgatgcccagcagtg	16	10	0	1	rs143553379		TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr11:4870156C>T	uc010qyo.1	-	1	283	c.283G>A	c.(283-285)GCT>ACT	p.A95T		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGCACCAGCAAGGGCGATG	0.537													T	4870156	T	T	4870156	3	4	22	1	0	0	0	0	1	0	0	0	11105	710	25	3	691	3	OR51S1	11	4870156	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08		4870156	130136360	50	1402											
C11orf16	56673	broad.mit.edu	37	chr11	8953775	8953775	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccaaggtggagcagcaccGtcccagccaggggccttcag	13	15	1	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr11:8953775G>A	uc001mhb.3	-	2	205	c.81C>T	c.(79-81)GAC>GAT	p.D27D	C11orf16_uc001mhc.3_Silent_p.D27D	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	27										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GAGCAGCACCGTCCCAGCCAG	0.622													A	8953775	A	A	8953775	2	1	22	1	0	0	0	0	0	0	0	1	1631	1136	40	1		1	C11orf16	11	8953775	Silent	SNP	G	TCGA-06-0145-01A-01W-0224-08	4083619	8953775	126052741	51	1403											
FOLH1	2346	broad.mit.edu	37	chr11	49175930	49175930	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcaaacaccatccctcctcGaacctgggccacagtgaggt	8	16	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr11:49175930G>A	uc001ngy.2	-	16	1999	c.1738C>T	c.(1738-1740)CGA>TGA	p.R580*	FOLH1_uc001ngx.2_Nonsense_Mutation_p.R12*|FOLH1_uc001ngz.2_Nonsense_Mutation_p.R580*|FOLH1_uc009yly.2_Nonsense_Mutation_p.R565*|FOLH1_uc009ylz.2_Nonsense_Mutation_p.R565*|FOLH1_uc009yma.2_Nonsense_Mutation_p.R272*	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	580	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	ATCCCTCCTCGAACCTGGGCC	0.413													A	49175930	A	A	49175930	4	1	22	1	0	0	0	0	0	1	0	0	5979	1066	37	2	530	2	FOLH1	11	49175930	Nonsense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	40222155	49175930	85830586	52	1404											
OR5D18	219438	broad.mit.edu	37	chr11	55587854	55587854	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctcccacctgactgccatcaCcatcttccatggcaccatcc	4	20	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr11:55587854C>A	uc010rin.1	+	1	749	c.749C>A	c.(748-750)ACC>AAC	p.T250N		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				ACTGCCATCACCATCTTCCAT	0.517													A	55587854	A	A	55587854	3	1	22	1	0	0	0	0	1	0	0	0	11157	507	18	5	751	5	OR5D18	11	55587854	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	6411924	55587854	79418662	53	1405											
MS4A7	58475	broad.mit.edu	37	chr11	60150731	60150731	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgaagattacctgcagaaCgggctgccaacagaaaccac	9	12	0	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr11:60150731C>T	uc001npe.2	+	2	262	c.117C>T	c.(115-117)AAC>AAT	p.N39N	MS4A7_uc001npf.2_Silent_p.N39N|MS4A7_uc001npg.2_Silent_p.N39N|MS4A7_uc001nph.2_Silent_p.N39N|MS4A14_uc001npi.2_Intron|MS4A7_uc009ymx.1_Silent_p.N39N	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	39	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						ACCTGCAGAACGGGCTGCCAA	0.438													T	60150731	T	T	60150731	2	4	22	1	0	0	0	0	0	0	0	1	9866	535	19	1		1	MS4A7	11	60150731	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	4562877	60150731	74855785	54	1406											
FAU	2197	broad.mit.edu	37	chr11	64889007	64889007	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgctacttccagggtagtcAgggcctccaccccgcactgg	11	16	1	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr11:64889007A>G	uc001ocx.2	-	3	292	c.185T>C	c.(184-186)CTG>CCG	p.L62P	FAU_uc001ocy.1_Missense_Mutation_p.L62P|MRPL49_uc001ocz.1_5'Flank|MRPL49_uc001oda.1_5'Flank	NM_001997	NP_001988	P35544	UBIM_HUMAN	ubiquitin-like protein fubi and ribosomal	62											0						CAGGGTAGTCAGGGCCTCCAC	0.612													G	64889007	G	G	64889007	3	3	22	1	0	0	0	0	1	0	0	0	5694	188	7	4	228	4	FAU	11	64889007	Missense_Mutation	SNP	A	TCGA-06-0145-01A-01W-0224-08	4738276	64889007	70117509	55	1407											
FOLH1B	219595	broad.mit.edu	37	chr11	89424164	89424164	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acctcactgtggcccaggttCgaggagggatggtgtttgag	16	8	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr11:89424164C>T	uc001pda.2	+	11	1340	c.814C>T	c.(814-816)CGA>TGA	p.R272*		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	272					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGCCCAGGTTCGAGGAGGGAT	0.408													T	89424164	T	T	89424164	4	4	22	1	0	0	0	0	0	1	0	0	5980	876	31	2	848	2	FOLH1B	11	89424164	Nonsense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	24535157	89424164	45582352	56	1408											
MPZL2	10205	broad.mit.edu	37	chr11	118130818	118130818	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcggcccatcgctttttccGgtaatgctggaagaggacca	11	11	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr11:118130818G>A	uc001psn.2	-	4	676	c.535C>T	c.(535-537)CGG>TGG	p.R179W	MPZL2_uc001pso.2_Missense_Mutation_p.R179W|MPZL2_uc001psp.1_Missense_Mutation_p.R179W	NM_005797	NP_005788	O60487	MPZL2_HUMAN	myelin protein zero-like 2 precursor	179	Cytoplasmic (Potential).				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				skin(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		CGCTTTTTCCGGTAATGCTGG	0.478													A	118130818	A	A	118130818	3	1	22	1	0	0	0	0	1	0	0	0	9750	1115	39	2	120	2	MPZL2	11	118130818	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	28706654	118130818	16875698	57	1409											
CHEK1	1111	broad.mit.edu	37	chr11	125503112	125503112	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtatttcggtataataatcGtgagcgtttgttgaacaaga	10	4	0	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr11:125503112G>A	uc009zbo.2	+	6	1371	c.479G>A	c.(478-480)CGT>CAT	p.R160H	CHEK1_uc010sbh.1_Missense_Mutation_p.R176H|CHEK1_uc010sbi.1_Missense_Mutation_p.R160H|CHEK1_uc001qcf.3_Missense_Mutation_p.R160H|CHEK1_uc009zbp.2_Missense_Mutation_p.R160H|CHEK1_uc001qcg.3_Missense_Mutation_p.R160H|CHEK1_uc009zbq.2_Missense_Mutation_p.R160H|CHEK1_uc001qci.1_RNA	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	160	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity	p.R160H(1)		central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		TATAATAATCGTGAGCGTTTG	0.363								Other_conserved_DNA_damage_response_genes					A	125503112	A	A	125503112	3	1	22	1	0	0	0	0	1	0	0	0	3334	1145	40	1	497	1	CHEK1	11	125503112	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	7372294	125503112	9503404	58	1410											
TEAD4	7004	broad.mit.edu	37	chr12	3128315	3128315	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcagcaaacctatgctgtcCagcctccgctgcctctgcca	7	18	2	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr12:3128315C>T	uc010sej.1	+	8	836	c.559C>T	c.(559-561)CAG>TAG	p.Q187*	TEAD4_uc010sek.1_Nonsense_Mutation_p.Q144*|TEAD4_uc001qln.2_Nonsense_Mutation_p.Q59*	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	188					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CTATGCTGTCCAGCCTCCGCT	0.677													T	3128315	T	T	3128315	4	4	22	1	0	0	0	0	0	1	0	0	15738	595	21	3	584	3	TEAD4	12	3128315	Nonsense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08		3128315	130723580	59	1411											
TAS2R30	259293	broad.mit.edu	37	chr12	11286159	11286159	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagaaaggaggtcacagtttGcaaagcttttatgtggacct	11	6	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr12:11286159G>A	uc009zhs.1	-	1	685	c.685C>T	c.(685-687)CAA>TAA	p.Q229*	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_001097643	NP_001091112			type 2 taste receptor member 30												0						GTCACAGTTTGCAAAGCTTTT	0.418													A	11286159	A	A	11286159	4	1	22	1	0	0	0	0	0	1	0	0	15570	1328	46	3	278	3	TAS2R30	12	11286159	Nonsense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	8157844	11286159	122565736	60	1412											
PIK3C2G	5288	broad.mit.edu	37	chr12	18658236	18658236	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatgaattaggccttgaggaActttttctactcctgtgctg	9	8	1	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr12:18658236A>G	uc001rdt.2	+	23	3157	c.3041A>G	c.(3040-3042)AAC>AGC	p.N1014S	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.N1055S|PIK3C2G_uc010sic.1_Missense_Mutation_p.N833S	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1014	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.N1014S(1)		lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GCCTTGAGGAACTTTTTCTAC	0.378													G	18658236	G	G	18658236	3	3	22	1	0	0	0	0	1	0	0	0	11911	43	2	4	3127	4	PIK3C2G	12	18658236	Missense_Mutation	SNP	A	TCGA-06-0145-01A-01W-0224-08	7372077	18658236	115193659	61	1413											
PPFIBP1	8496	broad.mit.edu	37	chr12	27841240	27841240	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttcccatagaataccatcGccccatcagaagttcagaag	7	12	2	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr12:27841240G>A	uc001ric.1	+	25	2775	c.2398G>A	c.(2398-2400)GCC>ACC	p.A800T	PPFIBP1_uc010sjr.1_Missense_Mutation_p.A631T|PPFIBP1_uc001rib.1_Missense_Mutation_p.A794T|PPFIBP1_uc001ria.2_Missense_Mutation_p.A769T|PPFIBP1_uc001rid.1_Missense_Mutation_p.A647T|PPFIBP1_uc001rif.1_Missense_Mutation_p.A307T	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	800					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					GAATACCATCGCCCCATCAGA	0.468													A	27841240	A	A	27841240	3	1	22	1	0	0	0	0	1	0	0	0	12313	1087	38	1	2516	1	PPFIBP1	12	27841240	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	9183004	27841240	106010655	62	1414											
SCN8A	6334	broad.mit.edu	37	chr12	52200784	52200784	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggatctgccaatggtgagCggggatcgcatccactgctt	13	10	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr12:52200784C>T	uc001ryw.2	+	27	5692	c.5514C>T	c.(5512-5514)AGC>AGT	p.S1838S		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1838					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CAATGGTGAGCGGGGATCGCA	0.562													T	52200784	T	T	52200784	2	4	22	1	0	0	0	0	0	0	0	1	13924	767	27	1		1	SCN8A	12	52200784	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	24359544	52200784	81651111	63	1415											
LUM	4060	broad.mit.edu	37	chr12	91502375	91502375	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgggcccacagactctgtcaGgttgttgtggtttatatgca	12	8	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr12:91502375G>T	uc001tbm.2	-	2	771	c.382C>A	c.(382-384)CTG>ATG	p.L128M	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	128	LRR 3.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent	p.L128M(1)		central_nervous_system(2)	2						GACTCTGTCAGGTTGTTGTGG	0.418													T	91502375	T	T	91502375	3	4	22	1	0	0	0	0	1	0	0	0	9085	991	35	5	642	5	LUM	12	91502375	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	39301591	91502375	42349520	64	1416											
SDS	10993	broad.mit.edu	37	chr12	113835119	113835119	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacacagcaggcccccgccGcccactgacagcgcgatggc	11	20	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr12:113835119G>A	uc001tvg.2	-	6	626	c.504C>T	c.(502-504)GGC>GGT	p.G168G	SDS_uc001tvh.1_Silent_p.G168G	NM_006843	NP_006834	P20132	SDHL_HUMAN	serine dehydratase	168					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			pancreas(1)	1					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GGCCCCCGCCGCCCACTGACA	0.662													A	113835119	A	A	113835119	2	1	22	1	0	0	0	0	0	0	0	1	13975	1074	38	1		1	SDS	12	113835119	Silent	SNP	G	TCGA-06-0145-01A-01W-0224-08	22332744	113835119	20016776	65	1417											
FAM123A	219287	broad.mit.edu	37	chr13	25745233	25745233	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacaggctctcccttgccGttttccgagcgcccgttctt	8	17	2	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr13:25745233G>A	uc001uqb.2	-	1	625	c.525C>T	c.(523-525)AAC>AAT	p.N175N	FAM123A_uc001uqa.2_Silent_p.N175N|FAM123A_uc001uqc.2_Silent_p.N175N	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	175										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CTCCCTTGCCGTTTTCCGAGC	0.677													A	25745233	A	A	25745233	2	1	22	1	0	0	0	0	0	0	0	1	5422	1136	40	1		1	FAM123A	13	25745233	Silent	SNP	G	TCGA-06-0145-01A-01W-0224-08		25745233	89424645	66	1418											
PAN3	255967	broad.mit.edu	37	chr13	28840979	28840979	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tacaaagctgtaaacagcaaAgatgatctgccatattgcct	7	9	1	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr13:28840979A>T	uc001urz.2	+	9	1109	c.1101A>T	c.(1099-1101)AAA>AAT	p.K367N	PAN3_uc010tdo.1_Missense_Mutation_p.K513N|PAN3_uc001ury.2_Missense_Mutation_p.K201N|PAN3_uc001urx.2_Missense_Mutation_p.K313N	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	513	Protein kinase.|Interaction with PAN2.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TAAACAGCAAAGATGATCTGC	0.373													T	28840979	T	T	28840979	3	4	22	1	0	0	0	0	1	0	0	0	11415	69	3	5	1577	5	PAN3	13	28840979	Missense_Mutation	SNP	A	TCGA-06-0145-01A-01W-0224-08	3095746	28840979	86328899	67	1419											
STARD13	90627	broad.mit.edu	37	chr13	33704189	33704189	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcactggcccggctggctgcGactgtcgctgcctccactgc	13	17	0	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr13:33704189G>A	uc001uuw.2	-	5	751	c.625C>T	c.(625-627)CGC>TGC	p.R209C	STARD13_uc001uuu.2_Missense_Mutation_p.R201C|STARD13_uc001uuv.2_Missense_Mutation_p.R91C|STARD13_uc001uux.2_Missense_Mutation_p.R174C|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.R194C	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	209					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GGCTGGCTGCGACTGTCGCTG	0.627													A	33704189	A	A	33704189	3	1	22	1	0	0	0	0	1	0	0	0	15255	1058	37	2	2756	2	STARD13	13	33704189	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	4863210	33704189	81465689	68	1420											
LRFN5	145581	broad.mit.edu	37	chr14	42356674	42356674	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcaattcctgaagaagagttTttgtgtgagcctcctctcat	8	9	2	4			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr14:42356674T>A	uc001wvm.2	+	3	2044	c.846T>A	c.(844-846)TTT>TTA	p.F282L	LRFN5_uc010ana.2_Missense_Mutation_p.F282L	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	282	Extracellular (Potential).|LRRCT.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AAGAAGAGTTTTTGTGTGAGC	0.502										HNSCC(30;0.082)			A	42356674	A	A	42356674	3	1	22	1	0	0	0	0	1	0	0	0	8941	1838	64	5	848	5	LRFN5	14	42356674	Missense_Mutation	SNP	T	TCGA-06-0145-01A-01W-0224-08		42356674	64992866	69	1421											
PPP2R5E	5529	broad.mit.edu	37	chr14	63858710	63858710	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tggttctgtgagtgaaggatCtttctccagaaactgtacta	10	7	3	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr14:63858710C>A	uc001xgd.1	-	9	1473	c.883G>T	c.(883-885)GAT>TAT	p.D295Y	PPP2R5E_uc010tsf.1_Missense_Mutation_p.D219Y|PPP2R5E_uc010tsg.1_Missense_Mutation_p.D219Y|PPP2R5E_uc001xge.2_Missense_Mutation_p.D295Y|PPP2R5E_uc010tsh.1_Missense_Mutation_p.D295Y|PPP2R5E_uc001xgf.1_RNA	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	295					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		AGTGAAGGATCTTTCTCCAGA	0.294													A	63858710	A	A	63858710	3	1	22	1	0	0	0	0	1	0	0	0	12396	913	32	5	544	5	PPP2R5E	14	63858710	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	21502036	63858710	43490830	70	1422											
PAPLN	89932	broad.mit.edu	37	chr14	73717702	73717702	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acggcacgacctgctaccccGtcgcaggcacctttgacgct	10	17	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr14:73717702G>A	uc010ttx.1	+	6	716	c.553G>A	c.(553-555)GTC>ATC	p.V185I	PAPLN_uc001xnw.3_Missense_Mutation_p.V185I|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.V185I	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	185						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CTGCTACCCCGTCGCAGGCAC	0.632													A	73717702	A	A	73717702	3	1	22	1	0	0	0	0	1	0	0	0	11428	1145	40	1	575	1	PAPLN	14	73717702	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	9858992	73717702	33631838	71	1423											
CRIP1	1396	broad.mit.edu	37	chr14	105954816	105954816	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttctctgcaggctttgggCggggcggagccgagagccac	16	13	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr14:105954816C>T	uc001yri.3	+	5	316	c.202C>T	c.(202-204)CGG>TGG	p.R68W	C14orf80_uc001yrj.2_5'Flank|C14orf80_uc001yrk.2_5'Flank|C14orf80_uc001yrn.2_5'Flank|C14orf80_uc001yro.2_5'Flank|C14orf80_uc001yrm.2_5'Flank	NM_001311	NP_001302	P50238	CRIP1_HUMAN	cysteine-rich protein 1 (intestinal)	68	Gly-rich.				cell proliferation	cytoplasm	zinc ion binding				0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.235)		AGGCTTTGGGCGGGGCGGAGC	0.547													T	105954816	T	T	105954816	3	4	22	1	0	0	0	0	1	0	0	0	3874	759	27	1	216	1	CRIP1	14	105954816	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	32237114	105954816	1394724	72	1424											
HDC	3067	broad.mit.edu	37	chr15	50549631	50549631	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagggaggtacctgcaggacGcctccgccctggctgctggg	16	13	0	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr15:50549631G>A	uc001zxz.2	-	4	538	c.432C>T	c.(430-432)GGC>GGT	p.G144G	HDC_uc010uff.1_Silent_p.G144G|HDC_uc010bet.1_Intron|HDC_uc010beu.1_Silent_p.G144G	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	144					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	CCTGCAGGACGCCTCCGCCCT	0.562													A	50549631	A	A	50549631	2	1	22	1	0	0	0	0	0	0	0	1	7015	1074	38	1		1	HDC	15	50549631	Silent	SNP	G	TCGA-06-0145-01A-01W-0224-08		50549631	51981761	73	1425											
ADCY9	115	broad.mit.edu	37	chr16	4033425	4033425	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gactagcaaacgtcttcacgGgggagttctttatgacctgt	11	9	3	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr16:4033425G>A	uc002cvx.2	-	7	2866	c.2327C>T	c.(2326-2328)CCC>CTC	p.P776L		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	776	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						CGTCTTCACGGGGGAGTTCTT	0.562													A	4033425	A	A	4033425	3	1	22	1	0	0	0	0	1	0	0	0	301	1232	43	3	1754	3	ADCY9	16	4033425	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08		4033425	86321328	74	1426											
MYH11	4629	broad.mit.edu	37	chr16	15844112	15844112	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccactgtgcggaacatgccCttcttggtcttggaggcgct	12	13	2	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr16:15844112C>T	uc002ddy.2	-	16	2048	c.1941G>A	c.(1939-1941)AAG>AAA	p.K647K	MYH11_uc002ddv.2_Silent_p.K654K|MYH11_uc002ddw.2_Silent_p.K647K|MYH11_uc002ddx.2_Silent_p.K654K|MYH11_uc010bvg.2_Silent_p.K479K|MYH11_uc002dea.1_Silent_p.K353K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	647	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GGAACATGCCCTTCTTGGTCT	0.627			T	CBFB	AML								T	15844112	T	T	15844112	2	4	22	1	0	0	0	0	0	0	0	1	10031	680	24	3		3	MYH11	16	15844112	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	11810687	15844112	74510641	75	1427											
CD2BP2	10421	broad.mit.edu	37	chr16	30364599	30364599	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccaccagaccatctccccgcGactctgcttctaaaataaca	4	17	3	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr16:30364599G>A	uc002dxr.2	-	5	1071	c.818C>T	c.(817-819)TCG>TTG	p.S273L	CD2BP2_uc002dxs.2_Missense_Mutation_p.S273L	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	273					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						ATCTCCCCGCGACTCTGCTTC	0.572													A	30364599	A	A	30364599	3	1	22	1	0	0	0	0	1	0	0	0	2995	1059	37	2	215	2	CD2BP2	16	30364599	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	14520487	30364599	59990154	76	1428											
HYDIN	54768	broad.mit.edu	37	chr16	70867931	70867931	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctaaggaggaagagggggCgcaggagccccatgcattcc	16	11	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr16:70867931C>T	uc002ezr.2	-	79	13663	c.13535G>A	c.(13534-13536)CGC>CAC	p.R4512H	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4513										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GAAGAGGGGGCGCAGGAGCCC	0.557													T	70867931	T	T	70867931	3	4	22	1	0	0	0	0	1	0	0	0	7467	768	27	1	1859	1	HYDIN	16	70867931	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	40503332	70867931	19486822	77	1429											
HYDIN	54768	broad.mit.edu	37	chr16	71026070	71026070	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgctgggatggactccatctGggacactggggcactgtagg	16	9	1	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr16:71026070G>T	uc002ezr.2	-	24	3816	c.3688C>A	c.(3688-3690)CAG>AAG	p.Q1230K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1230										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GACTCCATCTGGGACACTGGG	0.498													T	71026070	T	T	71026070	3	4	22	1	0	0	0	0	1	0	0	0	7467	1357	47	5	11926	5	HYDIN	16	71026070	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	158139	71026070	19328683	78	1430											
YWHAE	7531	broad.mit.edu	37	chr17	1257637	1257637	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcatcaaaagctgcttttgCcaacctaaaggtatttcaat	5	9	3	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr17:1257637C>T	uc002fsj.2	-	5	735	c.583G>A	c.(583-585)GCA>ACA	p.A195T	YWHAE_uc002fsk.2_Missense_Mutation_p.A173T|YWHAE_uc010vqh.1_RNA|YWHAE_uc010vqi.1_RNA	NM_006761	NP_006752	P62258	1433E_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	195					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding			lung(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		GCTGCTTTTGCCAACCTAAAG	0.348													T	1257637	T	T	1257637	3	4	22	1	0	0	0	0	1	0	0	0	17499	739	26	3	192	3	YWHAE	17	1257637	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08		1257637	79937573	79	1431											
SLFN12L	342615	broad.mit.edu	37	chr17	33806205	33806205	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttaactctgttatctttcaCgtgccaggaatcaggctttt	7	10	4	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr17:33806205C>T	uc002hjn.2	-	3	1990	c.1111G>A	c.(1111-1113)GTG>ATG	p.V371M		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						TTATCTTTCACGTGCCAGGAA	0.448													T	33806205	T	T	33806205	3	4	22	1	0	0	0	0	1	0	0	0	14735	536	19	1	754	1	SLFN12L	17	33806205	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	32548568	33806205	47389005	80	1432											
KRT13	3860	broad.mit.edu	37	chr17	39659272	39659272	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcatctctgccagcacgcGggtcaggtcaatgcctgggg	13	14	4	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr17:39659272G>A	uc002hwu.1	-	4	877	c.814C>T	c.(814-816)CGC>TGC	p.R272C	KRT13_uc002hwv.1_Missense_Mutation_p.R272C|KRT13_uc002hww.2_Missense_Mutation_p.R165C|KRT13_uc010wfr.1_Missense_Mutation_p.R165C|KRT13_uc010cxo.2_Missense_Mutation_p.R272C|KRT13_uc002hwx.1_Missense_Mutation_p.R260C	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	272	Linker 12.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GCCAGCACGCGGGTCAGGTCA	0.602													A	39659272	A	A	39659272	3	1	22	1	0	0	0	0	1	0	0	0	8450	1116	39	2	582	2	KRT13	17	39659272	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	5853067	39659272	41535938	81	1433											
DHX58	79132	broad.mit.edu	37	chr17	40259776	40259776	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtagcgcctcaggtgaagCgcatacacccgttgctcctg	11	13	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr17:40259776C>T	uc002hyw.3	-	8	1066	c.843G>A	c.(841-843)GCG>GCA	p.A281A	DHX58_uc002hyv.3_RNA|DHX58_uc010wgf.1_Silent_p.A274A	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	281					innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCAGGTGAAGCGCATACACCC	0.657													T	40259776	T	T	40259776	2	4	22	1	0	0	0	0	0	0	0	1	4514	755	27	1		1	DHX58	17	40259776	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	600504	40259776	40935434	82	1434											
B4GALNT2	124872	broad.mit.edu	37	chr17	47246247	47246247	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctttgatccccgcctgcaaCgagtggctcactcaggtggg	13	13	2	1	rs112740954	byFrequency	TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr17:47246247C>T	uc002ion.2	+	10	1539	c.1480C>T	c.(1480-1482)CGA>TGA	p.R494*	B4GALNT2_uc010wlt.1_Nonsense_Mutation_p.R408*|B4GALNT2_uc010wlu.1_Nonsense_Mutation_p.R434*	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	494	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			CCGCCTGCAACGAGTGGCTCA	0.592													T	47246247	T	T	47246247	4	4	22	1	0	0	0	0	0	1	0	0	1267	528	19	1	1536	1	B4GALNT2	17	47246247	Nonsense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	6986471	47246247	33948963	83	1435											
FASN	2194	broad.mit.edu	37	chr17	80045208	80045208	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggcggggctaccttgggcCttgtcctgcagtgtgtacag	17	10	0	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr17:80045208C>T	uc002kdu.2	-	20	3333	c.3216G>A	c.(3214-3216)AAG>AAA	p.K1072K	FASN_uc002kdw.1_Silent_p.K288K	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1072					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	TACCTTGGGCCTTGTCCTGCA	0.672													T	80045208	T	T	80045208	2	4	22	1	0	0	0	0	0	0	0	1	5683	680	24	3		3	FASN	17	80045208	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	32798961	80045208	1150002	84	1436											
ZNF521	25925	broad.mit.edu	37	chr18	22902139	22902139	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcagtcttgtcttcaagtTtacagttggggtctgaaaaa	9	7	5	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr18:22902139T>C	uc002kvk.2	-	3	300	c.53A>G	c.(52-54)AAA>AGA	p.K18R	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.K18R|ZNF521_uc002kvl.2_5'UTR	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	18					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GTCTTCAAGTTTACAGTTGGG	0.423			T	PAX5	ALL								C	22902139	C	C	22902139	3	2	22	1	0	0	0	0	1	0	0	0	17962	1841	64	4	3906	4	ZNF521	18	22902139	Missense_Mutation	SNP	T	TCGA-06-0145-01A-01W-0224-08		22902139	55175109	85	1437											
SS18	6760	broad.mit.edu	37	chr18	23618584	23618584	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccatgactgtattggtccCcgtaatagtcttcctggcct	8	13	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr18:23618584C>T	uc002kvm.2	-	7	893	c.815G>A	c.(814-816)GGG>GAG	p.G272E	SS18_uc002kvn.2_Missense_Mutation_p.G272E|SS18_uc010xbf.1_Missense_Mutation_p.G190E|SS18_uc010xbg.1_Missense_Mutation_p.G220E|SS18_uc010xbh.1_Missense_Mutation_p.G220E|SS18_uc010xbi.1_Missense_Mutation_p.G249E|SS18_uc010dlz.1_Missense_Mutation_p.G220E	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	272	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					GTATTGGTCCCCGTAATAGTC	0.438			T	SSX1| SSX2	synovial sarcoma								T	23618584	T	T	23618584	3	4	22	1	0	0	0	0	1	0	0	0	15174	623	22	3	461	3	SS18	18	23618584	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	716445	23618584	54458664	86	1438											
TJP3	27134	broad.mit.edu	37	chr19	3746600	3746600	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccggccctcaaggcactgCgccagtggctggcgcctgcc	15	17	1	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr19:3746600C>T	uc010xhv.1	+	16	2227	c.2227C>T	c.(2227-2229)CGC>TGC	p.R743C	TJP3_uc010xhs.1_Missense_Mutation_p.R710C|TJP3_uc010xht.1_Missense_Mutation_p.R674C|TJP3_uc010xhu.1_Missense_Mutation_p.R719C|TJP3_uc010xhw.1_Missense_Mutation_p.R729C	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	724	Guanylate kinase-like.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGGCACTGCGCCAGTGGCT	0.647													T	3746600	T	T	3746600	3	4	22	1	0	0	0	0	1	0	0	0	15928	768	27	1	2289	1	TJP3	19	3746600	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08		3746600	55382383	87	1439											
CPAMD8	27151	broad.mit.edu	37	chr19	17007075	17007075	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgtcctgctgtaaaggccCcggggccacagaagccaggt	13	14	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr19:17007075C>T	uc002nfb.2	-	41	5511	c.5479G>A	c.(5479-5481)GGG>AGG	p.G1827R	CPAMD8_uc010xpj.1_5'UTR|CPAMD8_uc002nfd.1_Missense_Mutation_p.G292R	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1780						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TGTAAAGGCCCCGGGGCCACA	0.677													T	17007075	T	T	17007075	3	4	22	1	0	0	0	0	1	0	0	0	3795	623	22	3	327	3	CPAMD8	19	17007075	Missense_Mutation	SNP	C	TCGA-06-0145-01A-01W-0224-08	13260475	17007075	42121908	88	1440											
CPAMD8	27151	broad.mit.edu	37	chr19	17025572	17025572	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gccagctcccgggggtccacGaagataaagctgcgagcctg	14	13	0	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr19:17025572G>A	uc002nfb.2	-	28	3854	c.3822C>T	c.(3820-3822)TTC>TTT	p.F1274F		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1227						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGGGGTCCACGAAGATAAAGC	0.458													A	17025572	A	A	17025572	2	1	22	1	0	0	0	0	0	0	0	1	3795	1049	37	2		2	CPAMD8	19	17025572	Silent	SNP	G	TCGA-06-0145-01A-01W-0224-08	18497	17025572	42103411	89	1441											
PSG4	5672	broad.mit.edu	37	chr19	43702421	43702421	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tggagatggagggcttgggaGtctccactgtgcagaaaaca	15	7	1	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr19:43702421G>C	uc002ovy.2	-	3	539	c.437C>G	c.(436-438)ACT>AGT	p.T146S	PSG6_uc010xwk.1_5'UTR|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Intron|PSG4_uc002ovz.2_Missense_Mutation_p.T146S	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	146					defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GGGCTTGGGAGTCTCCACTGT	0.517													C	43702421	C	C	43702421	3	2	22	1	0	0	0	0	1	0	0	0	12657	1029	36	5	838	5	PSG4	19	43702421	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	26676849	43702421	15426562	90	1442											
ZNF234	10780	broad.mit.edu	37	chr19	44661986	44661986	+	Frame_Shift_Del	DEL	G	-	-													ggagtgtgggaagcacttcaGtcaggcctcaagtctccaac							TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr19:44661986delG	uc002oym.2	+	6	2124	c.1817delG	c.(1816-1818)AGTfs	p.S606fs	ZNF234_uc002oyl.3_Frame_Shift_Del_p.S606fs	NM_006630	NP_006621	Q14588	ZN234_HUMAN	zinc finger protein 234	606	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AAGCACTTCAGTCAGGCCTCA	0.468													-	44661986	-	-	44661986	7	5	22	1	0	1	0	1	0	0	0	0	17784	1029	36	0	1831	0	ZNF234	19	44661986	Frame_Shift_Del	DEL	G	TCGA-06-0145-01A-01W-0224-08	959565	44661986	14466997	91	1443											
NLRP2	55655	broad.mit.edu	37	chr19	55505643	55505643	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggttgatttctaggctttgGaactgcgacataactagcga	11	7	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr19:55505643G>A	uc002qij.2	+	11	2801	c.2715G>A	c.(2713-2715)TGG>TGA	p.W905*	NLRP2_uc010yfp.1_Nonsense_Mutation_p.W882*|NLRP2_uc010esn.2_Nonsense_Mutation_p.W881*|NLRP2_uc010eso.2_Nonsense_Mutation_p.W902*|NLRP2_uc010esp.2_Nonsense_Mutation_p.W883*	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	905	LRR 4.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTAGGCTTTGGAACTGCGACA	0.483													A	55505643	A	A	55505643	4	1	22	1	0	0	0	0	0	1	0	0	10477	1183	41	3	2753	3	NLRP2	19	55505643	Nonsense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	10843657	55505643	3623340	92	1444											
NLRP8	126205	broad.mit.edu	37	chr19	56459556	56459556	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagcgtttccctggacgacgCgcttgggatgtgacttcgaa	14	10	0	1	rs146471073		TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr19:56459556C>T	uc002qmh.2	+	1	359	c.288C>T	c.(286-288)CGC>CGT	p.R96R	NLRP8_uc010etg.2_Silent_p.R96R	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	96	DAPIN.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTGGACGACGCGCTTGGGATG	0.507													T	56459556	T	T	56459556	2	4	22	1	0	0	0	0	0	0	0	1	10483	755	27	1		1	NLRP8	19	56459556	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	953913	56459556	2669427	93	1445											
SLC32A1	140679	broad.mit.edu	37	chr20	37356997	37356997	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgggcgcctgaagtcctgGgggctgacgctgcgctgcgc	18	13	0	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr20:37356997G>A	uc002xjc.2	+	2	1556	c.1293G>A	c.(1291-1293)TGG>TGA	p.W431*		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	431	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TGAAGTCCTGGGGGCTGACGC	0.662													A	37356997	A	A	37356997	4	1	22	1	0	0	0	0	0	1	0	0	14565	1241	43	3	1299	3	SLC32A1	20	37356997	Nonsense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08		37356997	25668523	94	1446											
EYA2	2139	broad.mit.edu	37	chr20	45811961	45811961	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	aaggagagctgcttcgagagGataatgcagagattcggcag	15	6	0	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr20:45811961G>C	uc002xsm.2	+	15	1832	c.1458G>C	c.(1456-1458)AGG>AGC	p.R486S	EYA2_uc010ghp.2_Missense_Mutation_p.R407S|EYA2_uc002xsn.2_Missense_Mutation_p.R491S|EYA2_uc002xso.2_Missense_Mutation_p.R486S|EYA2_uc002xsp.2_Missense_Mutation_p.R486S|EYA2_uc002xsq.2_Missense_Mutation_p.R456S	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	486					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				GCTTCGAGAGGATAATGCAGA	0.343													C	45811961	C	C	45811961	3	2	22	1	0	0	0	0	1	0	0	0	5329	1165	41	5	1512	5	EYA2	20	45811961	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	8454964	45811961	17213559	95	1447											
C21orf29	54084	broad.mit.edu	37	chr21	45948429	45948429	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgtcttccacctcggtacaCggtggctggggtcccagcgt	14	14	1	0			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chr21:45948429C>T	uc002zfe.1	-	6	894	c.828G>A	c.(826-828)CCG>CCA	p.P276P	C21orf29_uc010gpv.1_Silent_p.P208P	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	276					cell adhesion	extracellular region	structural molecule activity				0						CCTCGGTACACGGTGGCTGGG	0.577													T	45948429	T	T	45948429	2	4	22	1	0	0	0	0	0	0	0	1	2124	523	19	1		1	C21orf29	21	45948429	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08		45948429	2181466	96	1448											
GPR143	4935	broad.mit.edu	37	chrX	9711643	9711643	+	Frame_Shift_Del	DEL	C	-	-													atgattttgaaaaatcggatCttgatcacggctcccatcct							TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:9711643delC	uc004cst.1	-	6	789	c.789delG	c.(787-789)AAGfs	p.K263fs		NM_000273	NP_000264	P51810	GP143_HUMAN	G protein-coupled receptor 143	243	Cytoplasmic (Potential).				calcium-mediated signaling using intracellular calcium source|eye pigment biosynthetic process|melanosome organization|melanosome transport|phosphatidylinositol-mediated signaling|regulation of calcium-mediated signaling|visual perception	apical plasma membrane|Golgi apparatus|integral to membrane|lysosomal membrane|melanosome membrane|membrane fraction	dopamine binding|L-DOPA receptor activity|protein binding|tyrosine binding			ovary(1)	1		Hepatocellular(5;0.000888)				AAAATCGGATCTTGATCACGG	0.393													-	9711643	-	-	9711643	7	5	22	1	0	1	0	1	0	0	0	0	6651	912	32	0	501	0	GPR143	23	9711643	Frame_Shift_Del	DEL	C	TCGA-06-0145-01A-01W-0224-08		9711643	145558917	97	1449											
SCML2	10389	broad.mit.edu	37	chrX	18260650	18260650	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	catccacagaccaggttgaaGggtccttagagaagccttgt	11	10	0	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:18260650G>T	uc004cyl.2	-	14	2040	c.1883C>A	c.(1882-1884)CCT>CAT	p.P628H	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Intron|SCML2_uc011miz.1_Intron|SCML2_uc010nfc.2_Intron	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	628					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					CCAGGTTGAAGGGTCCTTAGA	0.453													T	18260650	T	T	18260650	3	4	22	1	0	0	0	0	1	0	0	0	13910	1000	35	5	227	5	SCML2	23	18260650	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	8549007	18260650	137009910	98	1450											
CNKSR2	22866	broad.mit.edu	37	chrX	21670464	21670464	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cattatcgataaagtcctagAcaatccagacttgacatcta	5	10	1	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:21670464A>G	uc004czx.1	+	22	2966	c.2930A>G	c.(2929-2931)GAC>GGC	p.D977G	CNKSR2_uc011mjo.1_Missense_Mutation_p.D947G	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	977					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						AAAGTCCTAGACAATCCAGAC	0.378													G	21670464	G	G	21670464	3	3	22	1	0	0	0	0	1	0	0	0	3607	275	10	4	3025	4	CNKSR2	23	21670464	Missense_Mutation	SNP	A	TCGA-06-0145-01A-01W-0224-08	3409814	21670464	133600096	99	1451											
DMD	1756	broad.mit.edu	37	chrX	31986588	31986588	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttccccagttgcattcaatGttctgacaacagtttgccgc	7	13	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:31986588G>A	uc004dda.1	-	45	6726	c.6482C>T	c.(6481-6483)ACA>ATA	p.T2161I	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Missense_Mutation_p.T817I|DMD_uc004dcx.2_Missense_Mutation_p.T820I|DMD_uc004dcz.2_Missense_Mutation_p.T2038I|DMD_uc004dcy.1_Missense_Mutation_p.T2157I|DMD_uc004ddb.1_Missense_Mutation_p.T2153I|DMD_uc010ngo.1_Missense_Mutation_p.T70I|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2161	Spectrin 15.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGCATTCAATGTTCTGACAAC	0.428													A	31986588	A	A	31986588	3	1	22	1	0	0	0	0	1	0	0	0	4580	1377	48	3	4863	3	DMD	23	31986588	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	10316124	31986588	123283972	100	1452											
PIM2	11040	broad.mit.edu	37	chrX	48771498	48771498	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtgtttgcatccaggggtcCagcaggatctcttccagtga	13	10	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:48771498C>A	uc004dls.2	-	6	1148	c.846G>T	c.(844-846)CTG>CTT	p.L282L	SLC35A2_uc004dlo.1_5'Flank|SLC35A2_uc011mml.1_5'Flank|SLC35A2_uc004dlp.1_5'Flank|SLC35A2_uc011mmm.1_5'Flank|SLC35A2_uc011mmn.1_5'Flank|SLC35A2_uc004dlq.2_5'Flank|SLC35A2_uc011mmo.1_5'Flank	NM_006875	NP_006866	Q9P1W9	PIM2_HUMAN	serine/threonine protein kinase pim-2	282	Protein kinase.				anti-apoptosis|cell proliferation|male meiosis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|response to virus		ATP binding|protein serine/threonine kinase activity			lung(3)|stomach(1)	4						TCCAGGGGTCCAGCAGGATCT	0.577													A	48771498	A	A	48771498	2	1	22	1	0	0	0	0	0	0	0	1	11928	581	21	5		5	PIM2	23	48771498	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	16784910	48771498	106499062	101	1453											
P2RY4	5030	broad.mit.edu	37	chrX	69478786	69478786	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	actgtgcagagcctggcaagGgctgatacaggcgacgagcc	15	11	0	2			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:69478786G>T	uc004dxz.1	-	1	869	c.689C>A	c.(688-690)CCC>CAC	p.P230H		NM_002565	NP_002556	P51582	P2RY4_HUMAN	pyrimidinergic receptor P2Y4	230	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1						GCCTGGCAAGGGCTGATACAG	0.582													T	69478786	T	T	69478786	3	4	22	1	0	0	0	0	1	0	0	0	11353	1232	43	5	412	5	P2RY4	23	69478786	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	20707288	69478786	85791774	102	1454											
KIF4A	24137	broad.mit.edu	37	chrX	69626855	69626855	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaggatggtgatggtgatgAtgatgagggggatgacgagg	21	1	0	7			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:69626855A>G	uc004dyg.2	+	28	3312	c.3185A>G	c.(3184-3186)GAT>GGT	p.D1062G	KIF4A_uc010nkw.2_Missense_Mutation_p.D1062G	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	1062	Globular.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						gatggtgatgatgatgagggg	0.303													G	69626855	G	G	69626855	3	3	22	1	0	0	0	0	1	0	0	0	8303	333	12	4	3291	4	KIF4A	23	69626855	Missense_Mutation	SNP	A	TCGA-06-0145-01A-01W-0224-08	148069	69626855	85643705	103	1455											
MED12	9968	broad.mit.edu	37	chrX	70351950	70351950	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actccctcttggagaacatcGccaaggccacaatcgaggtt	9	13	1	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:70351950G>A	uc004dyy.2	+	30	4346	c.4147G>A	c.(4147-4149)GCC>ACC	p.A1383T	MED12_uc011mpq.1_Missense_Mutation_p.A1383T|MED12_uc004dyz.2_Missense_Mutation_p.A1383T|MED12_uc004dza.2_Missense_Mutation_p.A1230T|MED12_uc010nla.2_Missense_Mutation_p.A9T	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1383					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GGAGAACATCGCCAAGGCCAC	0.507													A	70351950	A	A	70351950	3	1	22	1	0	0	0	0	1	0	0	0	9428	1087	38	1	4265	1	MED12	23	70351950	Missense_Mutation	SNP	G	TCGA-06-0145-01A-01W-0224-08	725095	70351950	84918610	104	1456											
DIAPH2	1730	broad.mit.edu	37	chrX	96171460	96171460	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggattacaaaggattctaggAgatgaaagaagtcttttact	10	4	2	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:96171460A>G	uc004efu.3	+	8	1152	c.756A>G	c.(754-756)GGA>GGG	p.G252G	DIAPH2_uc004eft.3_Silent_p.G252G|DIAPH2_uc004efs.2_Silent_p.G259G	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	252	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						GGATTCTAGGAGATGAAAGAA	0.299													G	96171460	G	G	96171460	2	3	22	1	0	0	0	0	0	0	0	1	4519	291	11	4		4	DIAPH2	23	96171460	Silent	SNP	A	TCGA-06-0145-01A-01W-0224-08	25819510	96171460	59099100	105	1457											
RGAG1	57529	broad.mit.edu	37	chrX	109694565	109694565	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attacagatgaagacaccgaAgcaatgtccaaagtgctaat	8	8	0	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:109694565A>G	uc004eor.1	+	3	966	c.720A>G	c.(718-720)GAA>GAG	p.E240E	RGAG1_uc011msr.1_Silent_p.E240E	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	240										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						AAGACACCGAAGCAATGTCCA	0.468													G	109694565	G	G	109694565	2	3	22	1	0	0	0	0	0	0	0	1	13274	69	3	4		4	RGAG1	23	109694565	Silent	SNP	A	TCGA-06-0145-01A-01W-0224-08	13523105	109694565	45575995	106	1458											
ODZ1	10178	broad.mit.edu	37	chrX	123637433	123637433	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttgaggattcaaaatgtgaTgcttattcaaagaccagcct	8	7	2	3			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:123637433T>C	uc004euj.2	-	19	3486	c.3422A>G	c.(3421-3423)CAT>CGT	p.H1141R	ODZ1_uc011muj.1_Missense_Mutation_p.H1140R|ODZ1_uc010nqy.2_Missense_Mutation_p.H1141R	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1141	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CAAAATGTGATGCTTATTCAA	0.358													C	123637433	C	C	123637433	3	2	22	1	0	0	0	0	1	0	0	0	10834	1464	51	4	4832	4	ODZ1	23	123637433	Missense_Mutation	SNP	T	TCGA-06-0145-01A-01W-0224-08	13942868	123637433	31633127	107	1459											
GABRE	2564	broad.mit.edu	37	chrX	151129839	151129839	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tccggcatcaatggtcatccTggaagggagaaaggagcctc	13	10	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:151129839T>A	uc004ffi.2	-	5	618	c.564_splice	c.e5-1	p.R188_splice	GABRE_uc011myd.1_Splice_Site|GABRE_uc011mye.1_Intron|MIR224_hsa-mir-224|MI0000301_5'Flank|MIR452_hsa-mir-452|MI0001733_5'Flank	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,						gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ATGGTCATCCTGGAAGGGAGA	0.493													A	151129839	A	A	151129839	5	1	22	1	0	0	0	0	0	0	1	0	6170	1594	55	5	978	5	GABRE	23	151129839	Splice_Site	SNP	T	TCGA-06-0145-01A-01W-0224-08	27492406	151129839	4140721	108	1460											
ATP2B3	492	broad.mit.edu	37	chrX	152801876	152801876	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggcctacggggatgtcagCgggctctgccggaggctgaa	18	10	2	1			TCGA-06-0145-01A-01W-0224-08	TCGA-06-0145-10A-01W-0224-08									Somatic	Phase_I	Capture				Illumina GAIIx	8f904068-2967-4b38-8813-3ad0a99e4af8	bd8a3db7-c259-4894-8104-9c0aab126a49	g.chrX:152801876C>T	uc004fht.1	+	1	297	c.171C>T	c.(169-171)AGC>AGT	p.S57S	ATP2B3_uc004fhs.1_Silent_p.S57S	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	57	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGATGTCAGCGGGCTCTGCC	0.667													T	152801876	T	T	152801876	2	4	22	1	0	0	0	0	0	0	0	1	1141	767	27	1		1	ATP2B3	23	152801876	Silent	SNP	C	TCGA-06-0145-01A-01W-0224-08	1672037	152801876	2468684	109	1461											
PI4KB	5298	broad.mit.edu	37	chr1	151265387	151265387	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtttggtggtgatagaccGcatactgccatccaccatct	10	11	1	2			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr1:151265387G>A	uc001ext.2	-	12	2807	c.2392C>T	c.(2392-2394)CGG>TGG	p.R798W	PI4KB_uc001exr.2_Missense_Mutation_p.R810W|PI4KB_uc001exs.2_Missense_Mutation_p.R783W|PI4KB_uc001exu.2_Missense_Mutation_p.R783W|PI4KB_uc010pcw.1_Missense_Mutation_p.R466W	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	798					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTGATAGACCGCATACTGCCA	0.577													A	151265387	A	A	151265387	3	1	23	1	0	0	0	0	1	0	0	0	11874	1086	38	1	62	1	PI4KB	1	151265387	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08		151265387	97985234	1	1462											
DUSP27	92235	broad.mit.edu	37	chr1	167097496	167097496	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccagagccctacttcttccGccggaccccagagtcctcag	8	19	2	2			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr1:167097496G>A	uc001geb.1	+	5	3128	c.3128G>A	c.(3127-3129)CGC>CAC	p.R1043H		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1043					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						TACTTCTTCCGCCGGACCCCA	0.587													A	167097496	A	A	167097496	3	1	23	1	0	0	0	0	1	0	0	0	4824	1087	38	1	3146	1	DUSP27	1	167097496	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08	15832109	167097496	82153125	2	1463											
TNN	63923	broad.mit.edu	37	chr1	175097757	175097757	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cccgtttcccacacccttcgGactgcagtcaggttcagcag	9	16	2	0			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr1:175097757G>A	uc001gkl.1	+	15	3318	c.3205G>A	c.(3205-3207)GAC>AAC	p.D1069N		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1069	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACACCCTTCGGACTGCAGTCA	0.547													A	175097757	A	A	175097757	3	1	23	1	0	0	0	0	1	0	0	0	16320	1174	41	3	3259	3	TNN	1	175097757	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08	8000261	175097757	74152864	3	1464											
CFHR5	81494	broad.mit.edu	37	chr1	196964976	196964976	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	taattttataataaacgggcCtaagaaaatacaatgtgtgg	8	4	0	1			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr1:196964976C>G	uc001gts.3	+	5	865	c.737C>G	c.(736-738)CCT>CGT	p.P246R		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	246	Sushi 4.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						ATAAACGGGCCTAAGAAAATA	0.333													G	196964976	G	G	196964976	3	3	23	1	0	0	0	0	1	0	0	0	3288	681	24	5	755	5	CFHR5	1	196964976	Missense_Mutation	SNP	C	TCGA-06-0151-01A-01D-1491-08	21867219	196964976	52285645	4	1465											
DDX59	83479	broad.mit.edu	37	chr1	200635187	200635187	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatcatctgcatttgaatggGagttggcacctcatagcctg	10	9	3	1			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr1:200635187G>A	uc009wzk.2	-	2	925	c.682C>T	c.(682-684)CCC>TCC	p.P228S	DDX59_uc010ppl.1_Missense_Mutation_p.P228S	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	228	Q motif.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						ATTTGAATGGGAGTTGGCACC	0.458													A	200635187	A	A	200635187	3	1	23	1	0	0	0	0	1	0	0	0	4376	1174	41	3	1205	3	DDX59	1	200635187	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08	3670211	200635187	48615434	5	1466											
ZRANB3	84083	broad.mit.edu	37	chr2	135965224	135965224	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	agcaaaaccgtgaatcccaaGagttcgctttacatgcttgc	8	11	0	2			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr2:135965224G>T	uc002tum.2	-	19	2906	c.2789C>A	c.(2788-2790)TCT>TAT	p.S930Y	ZRANB3_uc002tuk.2_Missense_Mutation_p.S473Y|ZRANB3_uc002tul.2_Missense_Mutation_p.S928Y	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	930						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		TGAATCCCAAGAGTTCGCTTT	0.428													T	135965224	T	T	135965224	3	4	23	1	0	0	0	0	1	0	0	0	18221	942	33	5	462	5	ZRANB3	2	135965224	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08		135965224	107234149	6	1467											
PRKRA	8575	broad.mit.edu	37	chr2	179296970	179296970	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acattgatattgtccattggCgctcagttcatctgtaatga	8	8	3	2	rs148050153		TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr2:179296970C>T	uc002umf.2	-	8	997	c.796G>A	c.(796-798)GCC>ACC	p.A266T	PRKRA_uc002umc.2_Missense_Mutation_p.A98T|PRKRA_uc002umd.2_Missense_Mutation_p.A241T|PRKRA_uc002ume.2_Missense_Mutation_p.A255T|PRKRA_uc002umg.2_Missense_Mutation_p.A153T|uc002umb.1_Intron|PRKRA_uc002umh.1_RNA	NM_003690	NP_003681	O75569	PRKRA_HUMAN	protein kinase, interferon-inducible double	266	DRBM 3.|Sufficient for self-association and interaction with TARBP2.				immune response|negative regulation of cell proliferation|production of siRNA involved in RNA interference|response to virus	perinuclear region of cytoplasm	double-stranded RNA binding|enzyme activator activity|protein homodimerization activity			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.00634)|all cancers(119;0.0265)			TGTCCATTGGCGCTCAGTTCA	0.418													T	179296970	T	T	179296970	3	4	23	1	0	0	0	0	1	0	0	0	12524	768	27	1	149	1	PRKRA	2	179296970	Missense_Mutation	SNP	C	TCGA-06-0151-01A-01D-1491-08	43331746	179296970	63902403	7	1468											
RAD54L2	23132	broad.mit.edu	37	chr3	51690054	51690054	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgcagtccacccccatcCccatgatgccccggcatgtc	8	19	0	1			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr3:51690054C>T	uc011bdt.1	+	19	3219	c.3094C>T	c.(3094-3096)CCC>TCC	p.P1032S	RAD54L2_uc003dbh.2_Missense_Mutation_p.P621S|RAD54L2_uc011bdu.1_Missense_Mutation_p.P726S|RAD54L2_uc003dbj.2_Missense_Mutation_p.P358S	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	1032						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CACCCCCATCCCCATGATGCC	0.522													T	51690054	T	T	51690054	3	4	23	1	0	0	0	0	1	0	0	0	12994	623	22	3	3164	3	RAD54L2	3	51690054	Missense_Mutation	SNP	C	TCGA-06-0151-01A-01D-1491-08		51690054	146332376	8	1469											
RAP2B	5912	broad.mit.edu	37	chr3	152880771	152880771	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccaggacatcaagcccatgCgggaccagatcatccgcgtg	11	14	2	1			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr3:152880771C>T	uc003ezr.2	+	1	743	c.289C>T	c.(289-291)CGG>TGG	p.R97W		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	97					Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			CAAGCCCATGCGGGACCAGAT	0.617													T	152880771	T	T	152880771	3	4	23	1	0	0	0	0	1	0	0	0	13041	759	27	1	291	1	RAP2B	3	152880771	Missense_Mutation	SNP	C	TCGA-06-0151-01A-01D-1491-08	101190717	152880771	45141659	9	1470											
NLGN1	22871	broad.mit.edu	37	chr3	173998531	173998531	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	atcaactgacatcactttcaGacctacgagaaaaaattctg	5	10	4	3			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr3:173998531G>C	uc003fio.1	+	7	2333	c.1910G>C	c.(1909-1911)AGA>ACA	p.R637T	NLGN1_uc003fip.1_Missense_Mutation_p.R637T	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	654	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ATCACTTTCAGACCTACGAGA	0.433													C	173998531	C	C	173998531	3	2	23	1	0	0	0	0	1	0	0	0	10461	942	33	5	1928	5	NLGN1	3	173998531	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08	21117760	173998531	24023899	10	1471											
ALB	213	broad.mit.edu	37	chr4	74274453	74274453	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgacaacccaaacctcccccGattggtgagaccagaggttg	10	13	0	3			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr4:74274453G>A	uc003hgs.3	+	4	486	c.413G>A	c.(412-414)CGA>CAA	p.R138Q	ALB_uc003hgw.3_Intron|ALB_uc011cbe.1_Intron|ALB_uc003hgt.3_Missense_Mutation_p.R138Q|ALB_uc010iii.2_Intron|ALB_uc003hgu.3_Intron|ALB_uc003hgv.3_Intron|ALB_uc011cbf.1_Missense_Mutation_p.R28Q|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'Flank	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	138	Albumin 1.		R -> G (in Yanomama-2).		bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AACCTCCCCCGATTGGTGAGA	0.398													A	74274453	A	A	74274453	3	1	23	1	0	0	0	0	1	0	0	0	486	1058	37	2	427	2	ALB	4	74274453	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08		74274453	116879823	11	1472											
PCDHB5	26167	broad.mit.edu	37	chr5	140516934	140516934	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgcggccaagcacaggctgGtggtgctggtcaaggacaat	15	10	1	0			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr5:140516934G>A	uc003liq.2	+	1	2135	c.1918G>A	c.(1918-1920)GTG>ATG	p.V640M		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	640	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACAGGCTGGTGGTGCTGGT	0.706													A	140516934	A	A	140516934	3	1	23	1	0	0	0	0	1	0	0	0	11545	1261	44	3	1920	3	PCDHB5	5	140516934	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08		140516934	40398326	12	1473											
BRAF	673	broad.mit.edu	37	chr7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acccactccatcgagatttcActgtagctagaccaaaatca	5	13	2	2			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				T	140453136	T	T	140453136	3	4	23	1	0	0	0	0	1	0	0	0	1496	159	6	5	517	5	BRAF	7	140453136	Missense_Mutation	SNP	A	TCGA-06-0151-01A-01D-1491-08		140453136	18685527	13	1474											
NFIB	4781	broad.mit.edu	37	chr9	14150145	14150145	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcagcccttctttcagtaccTgcttggtggagaagacagag	12	10	2	3			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr9:14150145T>C	uc003zle.2	-	5	1240	c.805A>G	c.(805-807)AGC>GGC	p.S269G	NFIB_uc003zld.2_Missense_Mutation_p.S17G|NFIB_uc003zlf.2_Missense_Mutation_p.S269G|NFIB_uc011lmo.1_Missense_Mutation_p.S269G	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	269					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		TTTCAGTACCTGCTTGGTGGA	0.328			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								C	14150145	C	C	14150145	3	2	23	1	0	0	0	0	1	0	0	0	10371	1594	55	4	477	4	NFIB	9	14150145	Missense_Mutation	SNP	T	TCGA-06-0151-01A-01D-1491-08		14150145	127063286	14	1475											
FLJ46321	389763	broad.mit.edu	37	chr9	84609194	84609194	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatccgtgtggcacagaagcAggagcccagggtccctacct	12	13	0	1			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr9:84609194A>G	uc004amn.2	+	4	3856	c.3809A>G	c.(3808-3810)CAG>CGG	p.Q1270R		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1270						integral to membrane					0						GCACAGAAGCAGGAGCCCAGG	0.537													G	84609194	G	G	84609194	3	3	23	1	0	0	0	0	1	0	0	0	5932	188	7	4	3823	4	FLJ46321	9	84609194	Missense_Mutation	SNP	A	TCGA-06-0151-01A-01D-1491-08	70459049	84609194	56604237	15	1476											
TNC	3371	broad.mit.edu	37	chr9	117844148	117844148	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggagctagaccagtttgCcggtaagaggtctctggcct	13	11	1	2			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr9:117844148C>T	uc004bjj.3	-	6	2669	c.2307G>A	c.(2305-2307)CGG>CGA	p.R769R	TNC_uc010mvf.2_Silent_p.R769R	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	769	Fibronectin type-III 2.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GACCAGTTTGCCGGTAAGAGG	0.522													T	117844148	T	T	117844148	2	4	23	1	0	0	0	0	0	0	0	1	16267	726	26	3		3	TNC	9	117844148	Silent	SNP	C	TCGA-06-0151-01A-01D-1491-08	33234954	117844148	23369283	16	1477											
PRKCQ	5588	broad.mit.edu	37	chr10	6470257	6470257	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttgatcagtgctctgtcgGcaaatgacagccggggcttc	13	10	2	2			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr10:6470257G>A	uc001ijj.1	-	18	2108	c.2033C>T	c.(2032-2034)GCC>GTC	p.A678V	PRKCQ_uc009xim.1_Missense_Mutation_p.A615V|PRKCQ_uc001iji.1_Missense_Mutation_p.A711V|PRKCQ_uc009xin.1_Missense_Mutation_p.A642V|PRKCQ_uc010qax.1_Missense_Mutation_p.A553V	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	678	AGC-kinase C-terminal.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						TGCTCTGTCGGCAAATGACAG	0.458													A	6470257	A	A	6470257	3	1	23	1	0	0	0	0	1	0	0	0	12515	1203	42	3	91	3	PRKCQ	10	6470257	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08		6470257	129064490	17	1478											
SF1	7536	broad.mit.edu	37	chr11	64537812	64537812	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcctcttccagctttttgCgggtgcggaactctcgggtg	13	12	2	0			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr11:64537812C>T	uc001obb.1	-	4	682	c.305G>A	c.(304-306)CGC>CAC	p.R102H	SF1_uc010rnm.1_5'Flank|SF1_uc010rnn.1_Missense_Mutation_p.R76H|SF1_uc001oaz.1_Missense_Mutation_p.R227H|SF1_uc001oba.1_Missense_Mutation_p.R102H|SF1_uc001obc.1_Missense_Mutation_p.R102H|SF1_uc001obd.1_Missense_Mutation_p.R102H|SF1_uc001obe.1_5'UTR|SF1_uc010rno.1_5'UTR	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	102					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						CAGCTTTTTGCGGGTGCGGAA	0.547													T	64537812	T	T	64537812	3	4	23	1	0	0	0	0	1	0	0	0	14145	768	27	1	1792	1	SF1	11	64537812	Missense_Mutation	SNP	C	TCGA-06-0151-01A-01D-1491-08		64537812	70468704	18	1479											
KRT7	3855	broad.mit.edu	37	chr12	52639222	52639222	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagttggaggccgccattgcCgaggctgaggagcgtgggga	19	8	0	1			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr12:52639222C>T	uc001saa.1	+	7	1138	c.1011C>T	c.(1009-1011)GCC>GCT	p.A337A	KRT7_uc009zmf.1_Intron	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	337	Rod.|Coil 2.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		CCGCCATTGCCGAGGCTGAGG	0.662													T	52639222	T	T	52639222	2	4	23	1	0	0	0	0	0	0	0	1	8483	639	23	2		2	KRT7	12	52639222	Silent	SNP	C	TCGA-06-0151-01A-01D-1491-08		52639222	81212673	19	1480											
HOXC11	3227	broad.mit.edu	37	chr12	54367422	54367422	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accccagcgccccgcacgcaAcccccgccggcttctactcc	7	24	1	0			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr12:54367422A>C	uc001sem.2	+	1	513	c.397A>C	c.(397-399)ACC>CCC	p.T133P		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	133					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCCGCACGCAACCCCCGCCGG	0.642			T	NUP98	AML								C	54367422	C	C	54367422	3	2	23	1	0	0	0	0	1	0	0	0	7310	43	2	5	399	5	HOXC11	12	54367422	Missense_Mutation	SNP	A	TCGA-06-0151-01A-01D-1491-08	1728200	54367422	79484473	20	1481											
MYO1A	4640	broad.mit.edu	37	chr12	57431824	57431824	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggtctgaagagaactgacctCgctgctgatgctcattgggc	13	10	2	4			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr12:57431824C>T	uc001smw.3	-	18	2033	c.1790G>A	c.(1789-1791)CGA>CAA	p.R597Q	MYO1A_uc010sqz.1_Missense_Mutation_p.R435Q|MYO1A_uc009zpd.2_Missense_Mutation_p.R597Q	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	597	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						GAACTGACCTCGCTGCTGATG	0.592													T	57431824	T	T	57431824	3	4	23	1	0	0	0	0	1	0	0	0	10068	884	31	2	1385	2	MYO1A	12	57431824	Missense_Mutation	SNP	C	TCGA-06-0151-01A-01D-1491-08	3064402	57431824	76420071	21	1482											
SELPLG	6404	broad.mit.edu	37	chr12	109017957	109017957	+	Frame_Shift_Del	DEL	C	-	-													taggtactcatattcggtggCctgtctccggtcccgggcaa							TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr12:109017957delC	uc001tni.2	-	2	287	c.127delG	c.(127-129)GCCfs	p.A43fs	SELPLG_uc001tnh.2_Frame_Shift_Del_p.A43fs|SELPLG_uc010sxe.1_Frame_Shift_Del_p.A59fs	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	43	Extracellular (Potential).				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						TATTCGGTGGCCTGTCTCCGG	0.582													-	109017957	-	-	109017957	7	5	23	1	0	1	0	1	0	0	0	0	14020	739	26	0	1089	0	SELPLG	12	109017957	Frame_Shift_Del	DEL	C	TCGA-06-0151-01A-01D-1491-08	51586133	109017957	24833938	22	1483											
FOXG1	2290	broad.mit.edu	37	chr14	29236962	29236988	+	In_Frame_Del	DEL	GGGCGAGGGCGGCAAGGACGGGGAGGG	-	-													ggggaggagaagaagggggcGggcgagggcggcaaggacgg					rs148157138	byFrequency	TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr14:29236962_29236988delGGGCGAGGGCGGCAAGGACGGGGAGGG	uc001wqe.2	+	1	676_702	c.477_503delGGGCGAGGGCGGCAAGGACGGGGAGGG	c.(475-504)GCGGGCGAGGGCGGCAAGGACGGGGAGGGG>GCG	p.GEGGKDGEG160del		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	160_168	Gly-rich.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		agaagggggcgggcgagggcggcaaggacggggaggggggcaaggag	0.401													-	29236988	-	-	29236962	7	5	23	1	0	1	0	1	0	0	0	0	6007	1103	39	0	479	0	FOXG1	14	29236962	In_Frame_Del	DEL	GGGCGAGGGCGGCAAGGACGGGGAGGG	TCGA-06-0151-01A-01D-1491-08		29236962	78112578	23	1484											
KRT222	125113	broad.mit.edu	37	chr17	38812794	38812794	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgctaaatgaagatcaaatcGaagagaaacagactttttcc	7	7	1	4			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr17:38812794G>A	uc002hvc.2	-	6	813	c.748C>T	c.(748-750)CGA>TGA	p.R250*	KRT222_uc010wfk.1_RNA|KRT222_uc002hvb.2_Nonsense_Mutation_p.R210*	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	truncated type I keratin KA21	250						intermediate filament	structural molecule activity			central_nervous_system(1)|skin(1)	2						AGATCAAATCGAAGAGAAACA	0.368													A	38812794	A	A	38812794	4	1	23	1	0	0	0	0	0	1	0	0	8459	1066	37	2	143	2	KRT222	17	38812794	Nonsense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08		38812794	42382416	24	1485											
ACPT	93650	broad.mit.edu	37	chr19	51295399	51295399	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggaggccaccgaggccgccGagtaccaggaggccctggag	18	13	0	0			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr19:51295399G>A	uc002pta.1	+	5	520	c.520G>A	c.(520-522)GAG>AAG	p.E174K		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	174	Extracellular (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CGAGGCCGCCGAGTACCAGGA	0.612													A	51295399	A	A	51295399	3	1	23	1	0	0	0	0	1	0	0	0	168	1059	37	2	538	2	ACPT	19	51295399	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08		51295399	7833584	25	1486											
ZNF470	388566	broad.mit.edu	37	chr19	57089037	57089037	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctgatcacataggacttattCagcataagagaactcatact	6	9	3	2			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr19:57089037C>T	uc002qnl.3	+	6	1916	c.1240C>T	c.(1240-1242)CAG>TAG	p.Q414*	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	414	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AGGACTTATTCAGCATAAGAG	0.413													T	57089037	T	T	57089037	4	4	23	1	0	0	0	0	0	1	0	0	17926	827	29	3	1254	3	ZNF470	19	57089037	Nonsense_Mutation	SNP	C	TCGA-06-0151-01A-01D-1491-08	5793638	57089037	2039946	26	1487											
UMODL1	89766	broad.mit.edu	37	chr21	43519223	43519223	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctggaggctggagtgctGtacagggtgaagaccagcta	18	7	0	2			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr21:43519223G>A	uc002zaf.1	+	7	1119	c.1119G>A	c.(1117-1119)CTG>CTA	p.L373L	UMODL1_uc002zad.1_Silent_p.L301L|UMODL1_uc002zae.1_Silent_p.L301L|UMODL1_uc002zag.1_Silent_p.L373L|UMODL1_uc010gow.1_Silent_p.L165L|UMODL1_uc002zai.1_Silent_p.L24L|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Silent_p.L24L|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Silent_p.L118L	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	373	Extracellular (Potential).|Fibronectin type-III 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CTGGAGTGCTGTACAGGGTGA	0.612													A	43519223	A	A	43519223	2	1	23	1	0	0	0	0	0	0	0	1	16977	1364	48	3		3	UMODL1	21	43519223	Silent	SNP	G	TCGA-06-0151-01A-01D-1491-08		43519223	4610672	27	1488											
ITGB2	3689	broad.mit.edu	37	chr21	46330269	46330269	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgctgaccttgaacttcGtgcactcctgagagaggact	11	11	0	4	rs148038936	by1000genomes	TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr21:46330269G>A	uc002zgd.2	-	2	121	c.77C>T	c.(76-78)ACG>ATG	p.T26M	ITGB2_uc002zge.2_Missense_Mutation_p.T26M|ITGB2_uc002zgf.3_Missense_Mutation_p.T26M|ITGB2_uc011afl.1_Translation_Start_Site|ITGB2_uc010gpw.2_Missense_Mutation_p.T26M|ITGB2_uc002zgg.2_Missense_Mutation_p.T26M	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	26	Extracellular (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	CTTGAACTTCGTGCACTCCTG	0.657													A	46330269	A	A	46330269	3	1	23	1	0	0	0	0	1	0	0	0	7894	1145	40	1	2288	1	ITGB2	21	46330269	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08	2811046	46330269	1799626	28	1489											
SLC35E4	339665	broad.mit.edu	37	chr22	31042730	31042730	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctggcgactctcgcctctgGgcctgcatcctgctcagctg	12	16	3	0			TCGA-06-0151-01A-01D-1491-08	TCGA-06-0151-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fea9ebc-8c1b-4078-af87-79c7f5b5470b	5d8879d4-295c-4a2a-a3fb-d402e2f1f8f5	g.chr22:31042730G>T	uc003ais.1	+	2	1410	c.765G>T	c.(763-765)TGG>TGT	p.W255C	SLC35E4_uc003ait.2_Intron	NM_001001479	NP_001001479	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	255	Leu-rich.					integral to membrane					0						CTCGCCTCTGGGCCTGCATCC	0.677													T	31042730	T	T	31042730	3	4	23	1	0	0	0	0	1	0	0	0	14587	1241	43	5	771	5	SLC35E4	22	31042730	Missense_Mutation	SNP	G	TCGA-06-0151-01A-01D-1491-08		31042730	20261836	29	1490											
DNAJC16	23341	broad.mit.edu	37	chr1	15888817	15888817	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaggcgtttcaagggaaatcAgcggtaagccacagagtctc	13	9	3	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr1:15888817A>C	uc001aws.2	+	9	1455	c.1335A>C	c.(1333-1335)TCA>TCC	p.S445S	DNAJC16_uc001awr.1_Silent_p.S445S|DNAJC16_uc001awt.2_Silent_p.S133S|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	445	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AAGGGAAATCAGCGGTAAGCC	0.473													C	15888817	C	C	15888817	2	2	24	1	0	0	0	0	0	0	0	1	4635	175	7	5		5	DNAJC16	1	15888817	Silent	SNP	A	TCGA-06-0152-01A-02W-0323-08		15888817	233361804	1	1491											
DOCK7	85440	broad.mit.edu	37	chr1	62993826	62993826	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ggaggattgtttttaccgttGacgtgaggaggaaactgcca	14	6	0	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr1:62993826G>C	uc001daq.2	-	31	3966	c.3932C>G	c.(3931-3933)TCA>TGA	p.S1311*	DOCK7_uc001dan.2_Nonsense_Mutation_p.S1172*|DOCK7_uc001dao.2_Nonsense_Mutation_p.S1172*|DOCK7_uc001dap.2_Nonsense_Mutation_p.S1280*|DOCK7_uc001dam.2_Nonsense_Mutation_p.S491*|DOCK7_uc010oov.1_Intron	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1311					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						TTTTACCGTTGACGTGAGGAG	0.423													C	62993826	C	C	62993826	4	2	24	1	0	0	0	0	0	1	0	0	4692	1294	45	5	2570	5	DOCK7	1	62993826	Nonsense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	47105009	62993826	186256795	2	1492											
OR10J1	26476	broad.mit.edu	37	chr1	159410403	159410403	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacatgaccagctgatctcGgtgacctacactgtcatcac	8	13	3	3			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr1:159410403G>A	uc010piv.1	+	1	855	c.855G>A	c.(853-855)TCG>TCA	p.S285S	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	285	Helical; Name=7; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					AGCTGATCTCGGTGACCTACA	0.517													A	159410403	A	A	159410403	2	1	24	1	0	0	0	0	0	0	0	1	10910	1103	39	2		2	OR10J1	1	159410403	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08	96416577	159410403	89840218	3	1493											
ATP1A4	480	broad.mit.edu	37	chr1	160144388	160144388	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggagccgttgtggccgtgaCaggtgacggggtgaacgact	19	8	0	3			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr1:160144388C>A	uc001fve.3	+	15	2641	c.2162C>A	c.(2161-2163)ACA>AAA	p.T721K	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.T224K|ATP1A4_uc001fvh.2_5'Flank	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	721	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGGCCGTGACAGGTGACGGG	0.542													A	160144388	A	A	160144388	3	1	24	1	0	0	0	0	1	0	0	0	1131	478	17	5	2220	5	ATP1A4	1	160144388	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	733985	160144388	89106233	4	1494											
SLC9A11	284525	broad.mit.edu	37	chr1	173505000	173505000	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgtatcttttctatacAatattccaagaaagttaaaa	3	5	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr1:173505000A>C	uc001giz.2	-	15	2167	c.1744T>G	c.(1744-1746)TGT>GGT	p.C582G	SLC9A11_uc009wwe.2_Missense_Mutation_p.C140G|SLC9A11_uc010pmq.1_Intron	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	582					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TTTTCTATACAATATTCCAAG	0.264													C	173505000	C	C	173505000	3	2	24	1	0	0	0	0	1	0	0	0	14711	130	5	5	1686	5	SLC9A11	1	173505000	Missense_Mutation	SNP	A	TCGA-06-0152-01A-02W-0323-08	13360612	173505000	75745621	5	1495											
HMCN1	83872	broad.mit.edu	37	chr1	186017944	186017945	+	Frame_Shift_Ins	INS	-	A	A													aaatgttgctggaaaaactgINSaaaaaaactacaatgtcaac							TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr1:186017944_186017945insA	uc001grq.1	+	42	6779_6780	c.6550_6551insA	c.(6550-6552)GAAfs	p.E2184fs		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2184	Ig-like C2-type 19.			E -> EK (in Ref. 1).	response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGGAAAAACTGAAAAAAACTAC	0.361													A	186017945	A	A	186017944	7	5	24	1	0	1	1	0	0	0	0	0	7220	1291	45	0	6716	0	HMCN1	1	186017944	Frame_Shift_Ins	INS	-	TCGA-06-0152-01A-02W-0323-08	12512944	186017944	63232677	6	1496											
AIDA	64853	broad.mit.edu	37	chr1	222860999	222860999	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tatgtaagaatattctttagGactagaataagaagataaag	8	2	1	4			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr1:222860999G>C	uc001hnn.2	-	5	496	c.291C>G	c.(289-291)ATC>ATG	p.I97M	AIDA_uc001hno.2_RNA|AIDA_uc010pus.1_Missense_Mutation_p.I73M	NM_022831	NP_073742	Q96BJ3	AIDA_HUMAN	axin interactor, dorsalization associated	97					dorsal/ventral pattern formation|negative regulation of JNK cascade|negative regulation of JUN kinase activity|regulation of protein homodimerization activity						0						TATTCTTTAGGACTAGAATAA	0.194													C	222860999	C	C	222860999	3	2	24	1	0	0	0	0	1	0	0	0	423	1188	41	5	653	5	AIDA	1	222860999	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	36843055	222860999	26389622	7	1497											
FEZ2	9637	broad.mit.edu	37	chr2	36810520	36810520	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctgccgtgaagaggggttcAtcattaacacaggagacgat	12	8	3	3			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr2:36810520A>C	uc002rph.2	-	3	515	c.468T>G	c.(466-468)GAT>GAG	p.D156E	FEZ2_uc002rpe.2_5'Flank|FEZ2_uc002rpf.2_5'UTR|FEZ2_uc002rpg.2_Missense_Mutation_p.D156E|FEZ2_uc002rpi.2_Missense_Mutation_p.D11E|FEZ2_uc002rpj.2_Missense_Mutation_p.D156E	NM_005102	NP_005093	Q9UHY8	FEZ2_HUMAN	zygin 2 isoform 1	156					axon guidance|signal transduction		protein binding			ovary(1)	1		all_hematologic(82;0.21)				AGAGGGGTTCATCATTAACAC	0.438													C	36810520	C	C	36810520	3	2	24	1	0	0	0	0	1	0	0	0	5824	214	8	5	702	5	FEZ2	2	36810520	Missense_Mutation	SNP	A	TCGA-06-0152-01A-02W-0323-08		36810520	206388853	8	1498											
CD8A	925	broad.mit.edu	37	chr2	87013056	87013056	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagggttagacgtatctcGccgaaaggctgggcttgtct	13	10	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr2:87013056G>A	uc002srt.2	-	6	1584	c.695C>T	c.(694-696)GCG>GTG	p.A232V	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Missense_Mutation_p.A232V|CD8A_uc010ytn.1_Missense_Mutation_p.A273V|CD8A_uc002sru.2_Missense_Mutation_p.A195V	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	232	Cytoplasmic (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						GACGTATCTCGCCGAAAGGCT	0.507													A	87013056	A	A	87013056	3	1	24	1	0	0	0	0	1	0	0	0	3044	1087	38	1	16	1	CD8A	2	87013056	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	50202536	87013056	156186317	9	1499											
TRIM43	129868	broad.mit.edu	37	chr2	96262159	96262159	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctaatggaaatgtgtcataaAccagatgtggagctgctcca	10	8	1	1	rs149986492		TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr2:96262159A>T	uc002suv.2	+	4	853	c.717A>T	c.(715-717)AAA>AAT	p.K239N		NM_138800	NP_620155	Q96BQ3	TRI43_HUMAN	tripartite motif-containing 43	239						intracellular	zinc ion binding			ovary(1)	1						TGTGTCATAAACCAGATGTGG	0.413													T	96262159	T	T	96262159	3	4	24	1	0	0	0	0	1	0	0	0	16515	40	2	5	727	5	TRIM43	2	96262159	Missense_Mutation	SNP	A	TCGA-06-0152-01A-02W-0323-08	9249103	96262159	146937214	10	1500											
GPR148	344561	broad.mit.edu	37	chr2	131486773	131486773	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggcactacagcttggccgGccctgatccagctcatcagc	11	15	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr2:131486773G>A	uc002trv.1	+	1	51	c.49G>A	c.(49-51)GCC>ACC	p.A17T		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	17	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					AGCTTGGCCGGCCCTGATCCA	0.612													A	131486773	A	A	131486773	3	1	24	1	0	0	0	0	1	0	0	0	6653	1203	42	3	51	3	GPR148	2	131486773	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	35224614	131486773	111712600	11	1501											
DLEC1	9940	broad.mit.edu	37	chr3	38104257	38104257	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctccaaagaagccagcaccGataggagaattccagagtac	9	12	0	3			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr3:38104257G>A	uc003cho.1	+	5	1080	c.1059G>A	c.(1057-1059)CCG>CCA	p.P353P	DLEC1_uc003chp.1_Silent_p.P353P|DLEC1_uc010hgv.1_Silent_p.P353P|DLEC1_uc010hgw.1_Silent_p.P52P|DLEC1_uc003chq.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	353					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AGCCAGCACCGATAGGAGAAT	0.463													A	38104257	A	A	38104257	2	1	24	1	0	0	0	0	0	0	0	1	4552	1045	37	2		2	DLEC1	3	38104257	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08		38104257	159918173	12	1502											
ULK4	54986	broad.mit.edu	37	chr3	41953077	41953077	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttgaccactcttgtgccctTttgcttgtctactctgagag	9	11	3	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr3:41953077T>G	uc003ckv.3	-	10	1172	c.971A>C	c.(970-972)AAA>ACA	p.K324T	ULK4_uc003ckw.2_Missense_Mutation_p.K324T|ULK4_uc003ckx.1_Missense_Mutation_p.K324T	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	324							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CTTGTGCCCTTTTGCTTGTCT	0.413													G	41953077	G	G	41953077	3	3	24	1	0	0	0	0	1	0	0	0	16975	1841	64	5	2968	5	ULK4	3	41953077	Missense_Mutation	SNP	T	TCGA-06-0152-01A-02W-0323-08	3848820	41953077	156069353	13	1503											
LRBA	987	broad.mit.edu	37	chr4	151788860	151788860	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataaagtgtctacccatacaCgccagccaccccactcatat	4	16	2	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr4:151788860C>T	uc010ipj.2	-	22	3203	c.2729G>A	c.(2728-2730)CGT>CAT	p.R910H	LRBA_uc003ilu.3_Missense_Mutation_p.R910H	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	910						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TACCCATACACGCCAGCCACC	0.343													T	151788860	T	T	151788860	3	4	24	1	0	0	0	0	1	0	0	0	8931	536	19	1	6010	1	LRBA	4	151788860	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08		151788860	39365416	14	1504											
DIMT1L	27292	broad.mit.edu	37	chr5	61686705	61686705	+	Frame_Shift_Del	DEL	G	-	-													aaacaaaaatgtaattacctGatgaagtcatctatgtccat							TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr5:61686705delG	uc003jta.2	-	11	1026	c.897delC	c.(895-897)ATCfs	p.I299fs		NM_014473	NP_055288	Q9UNQ2	DIMT1_HUMAN	dimethyladenosine transferase	299				Missing (in Ref. 2; AAH02841).		nucleolus	RNA binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			central_nervous_system(1)	1		Lung NSC(810;8.94e-06)|Prostate(74;0.0235)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.122)		GTAATTACCTGATGAAGTCAT	0.383													-	61686705	-	-	61686705	7	5	24	1	0	1	0	1	0	0	0	0	4523	1280	45	0	52	0	DIMT1L	5	61686705	Frame_Shift_Del	DEL	G	TCGA-06-0152-01A-02W-0323-08		61686705	119228555	15	1505											
PCDHGB3	56102	broad.mit.edu	37	chr5	140752102	140752102	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattctggcaatctccctgcGcctgcgatgctcctccagac	9	16	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr5:140752102G>A	uc003ljw.1	+	1	2141	c.2141G>A	c.(2140-2142)CGC>CAC	p.R714H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.R714H|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	714	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTCCCTGCGCCTGCGATGC	0.582													A	140752102	A	A	140752102	3	1	24	1	0	0	0	0	1	0	0	0	11564	1087	38	1	2143	1	PCDHGB3	5	140752102	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	79065397	140752102	40163158	16	1506											
FLT4	2324	broad.mit.edu	37	chr5	180048197	180048197	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactgcatctccagcgagtcGctcacgttcaccaggaggtc	10	15	3	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr5:180048197G>A	uc003mma.3	-	14	2155	c.2076C>T	c.(2074-2076)AGC>AGT	p.S692S	FLT4_uc003mlz.3_Silent_p.S692S|FLT4_uc003mmb.1_Silent_p.S225S|FLT4_uc011dgy.1_Silent_p.S692S	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	692	Ig-like C2-type 7.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CCAGCGAGTCGCTCACGTTCA	0.632									Congenital_Hereditary_Lymphedema				A	180048197	A	A	180048197	2	1	24	1	0	0	0	0	0	0	0	1	5944	1078	38	1		1	FLT4	5	180048197	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08	39296095	180048197	867063	17	1507											
GRM4	2914	broad.mit.edu	37	chr6	34004373	34004373	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctccccggccagtgcatcCgctctatctggcaatgacag	10	16	2	1	rs142049660	by1000genomes	TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr6:34004373C>T	uc003oir.3	-	8	1684	c.1514G>A	c.(1513-1515)CGG>CAG	p.R505Q	GRM4_uc011dsn.1_Missense_Mutation_p.R458Q|GRM4_uc010jvh.2_Missense_Mutation_p.R505Q|GRM4_uc010jvi.2_Missense_Mutation_p.R197Q|GRM4_uc003oio.2_Missense_Mutation_p.R197Q|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Missense_Mutation_p.R365Q|GRM4_uc003oiq.2_Missense_Mutation_p.R372Q|GRM4_uc011dsm.1_Missense_Mutation_p.R336Q	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	505	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CCAGTGCATCCGCTCTATCTG	0.647													T	34004373	T	T	34004373	3	4	24	1	0	0	0	0	1	0	0	0	6799	652	23	2	1236	2	GRM4	6	34004373	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08		34004373	137110694	18	1508											
DNAH8	1769	broad.mit.edu	37	chr6	38957817	38957817	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgagaagatgtttgaaccGtcattctgcttttatactgg	10	6	2	3	rs143472136	byFrequency	TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr6:38957817G>A	uc003ooe.1	+	86	13032	c.12432G>A	c.(12430-12432)CCG>CCA	p.P4144P		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGTTTGAACCGTCATTCTGCT	0.368													A	38957817	A	A	38957817	2	1	24	1	0	0	0	0	0	0	0	1	4607	1132	40	1		1	DNAH8	6	38957817	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08	4953444	38957817	132157250	19	1509											
OPN5	221391	broad.mit.edu	37	chr6	47763200	47763200	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgtgatcgtgttctcctaCgtaaagatcattgccaaggt	10	9	2	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr6:47763200C>T	uc003ozc.2	+	4	662	c.657C>T	c.(655-657)TAC>TAT	p.Y219Y	OPN5_uc003ozd.2_Silent_p.Y54Y	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	219	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						TGTTCTCCTACGTAAAGATCA	0.512													T	47763200	T	T	47763200	2	4	24	1	0	0	0	0	0	0	0	1	10883	547	19	1		1	OPN5	6	47763200	Silent	SNP	C	TCGA-06-0152-01A-02W-0323-08	8805383	47763200	123351867	20	1510											
PKHD1	5314	broad.mit.edu	37	chr6	51889738	51889738	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctgtgggaacaatgcaccGgatgagctcagcaccgatgt	12	12	1	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr6:51889738G>A	uc003pah.1	-	32	5146	c.4870C>T	c.(4870-4872)CGG>TGG	p.R1624W	PKHD1_uc003pai.2_Missense_Mutation_p.R1624W	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1624	Extracellular (Potential).|IPT/TIG 11.		R -> W (in ARPKD).		cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.R1624W(1)		lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ACAATGCACCGGATGAGCTCA	0.507													A	51889738	A	A	51889738	3	1	24	1	0	0	0	0	1	0	0	0	11971	1115	39	2	7537	2	PKHD1	6	51889738	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	4126538	51889738	119225329	21	1511											
OOEP	441161	broad.mit.edu	37	chr6	74079390	74079390	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtctctcagttcctgcacCggaaaccaccagggccggat	12	14	2	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr6:74079390C>T	uc003pgu.3	-	1	126	c.126G>A	c.(124-126)CCG>CCA	p.P42P	OOEP_uc003pgv.3_Intron	NM_001080507	NP_001073976	A6NGQ2	OOEP_HUMAN	oocyte expressed protein homolog	42						cytoplasm					0						GTTCCTGCACCGGAAACCACC	0.622													T	74079390	T	T	74079390	2	4	24	1	0	0	0	0	0	0	0	1	10870	639	23	2		2	OOEP	6	74079390	Silent	SNP	C	TCGA-06-0152-01A-02W-0323-08	22189652	74079390	97035677	22	1512											
FILIP1	27145	broad.mit.edu	37	chr6	76024625	76024625	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	catgctcttgagaaaacctcGaagccttgtgttcaaagtcc	8	11	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr6:76024625G>T	uc003pia.2	-	5	1296	c.923C>A	c.(922-924)TCG>TAG	p.S308*	FILIP1_uc003phy.1_Nonsense_Mutation_p.S308*|FILIP1_uc003phz.2_Nonsense_Mutation_p.S209*|FILIP1_uc010kbe.2_Nonsense_Mutation_p.S311*|FILIP1_uc003pib.1_Nonsense_Mutation_p.S60*	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	308	Potential.									skin(3)|ovary(1)	4						AGAAAACCTCGAAGCCTTGTG	0.423													T	76024625	T	T	76024625	4	4	24	1	0	0	0	0	0	1	0	0	5894	1059	37	5	2726	5	FILIP1	6	76024625	Nonsense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	1945235	76024625	95090442	23	1513											
SEC63	11231	broad.mit.edu	37	chr6	108225906	108225906	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaagtagggcaggacacttTtttagcatgaattgctgatc	11	6	0	3			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr6:108225906T>G	uc003psc.3	-	11	1250	c.981A>C	c.(979-981)AAA>AAC	p.K327N	SEC63_uc003psb.3_Missense_Mutation_p.K187N	NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	327	SEC63 1.|Cytoplasmic (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		CAGGACACTTTTTTAGCATGA	0.348													G	108225906	G	G	108225906	3	3	24	1	0	0	0	0	1	0	0	0	14005	1838	64	5	1345	5	SEC63	6	108225906	Missense_Mutation	SNP	T	TCGA-06-0152-01A-02W-0323-08	32201281	108225906	62889161	24	1514											
GPR126	57211	broad.mit.edu	37	chr6	142736937	142736937	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttttcattttttaggaaaTtgcgaagggattatccctcc	7	7	1	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr6:142736937T>C	uc010khc.2	+	20	3085	c.2674T>C	c.(2674-2676)TTG>CTG	p.L892L	GPR126_uc010khd.2_Silent_p.L864L|GPR126_uc010khe.2_Silent_p.L892L|GPR126_uc010khf.2_Silent_p.L864L	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	892	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		TTTTAGGAAATTGCGAAGGGA	0.403													C	142736937	C	C	142736937	2	2	24	1	0	0	0	0	0	0	0	1	6640	1490	52	4		4	GPR126	6	142736937	Silent	SNP	T	TCGA-06-0152-01A-02W-0323-08	34511031	142736937	28378130	25	1515											
RUNDC3B	154661	broad.mit.edu	37	chr7	87258211	87258211	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ggaggcggcaagaaaagcctGagcgcccgcaatgctgcggt	16	11	0	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr7:87258211G>C	uc003ujb.2	+	1	483	c.72G>C	c.(70-72)CTG>CTC	p.L24L	ABCB1_uc003uiz.1_Intron|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron|RUNDC3B_uc011khd.1_Silent_p.L24L|RUNDC3B_uc011khe.1_Silent_p.L24L|RUNDC3B_uc003ujc.2_Silent_p.L24L	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	24										skin(1)	1	Esophageal squamous(14;0.00164)					AGAAAAGCCTGAGCGCCCGCA	0.716													C	87258211	C	C	87258211	2	2	24	1	0	0	0	0	0	0	0	1	13745	1277	45	5		5	RUNDC3B	7	87258211	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08		87258211	71880452	26	1516											
RELN	5649	broad.mit.edu	37	chr7	103338350	103338350	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gttgcctgtgtccactgggtCgagactatcttctaaaacga	10	10	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr7:103338350C>T	uc003vca.2	-	10	1253	c.1093G>A	c.(1093-1095)GAC>AAC	p.D365N	RELN_uc010liz.2_Missense_Mutation_p.D365N	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	365					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCACTGGGTCGAGACTATCT	0.423													T	103338350	T	T	103338350	3	4	24	1	0	0	0	0	1	0	0	0	13220	884	31	2	9513	2	RELN	7	103338350	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	16080139	103338350	55800313	27	1517											
CHCHD3	54927	broad.mit.edu	37	chr7	132754903	132754903	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aattaaaattcagcaataccTgaggcaccataagcaccaga	6	10	1	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr7:132754903T>C	uc003vre.2	-	2	304	c.168A>G	c.(166-168)TCA>TCG	p.S56S	CHCHD3_uc010lmi.2_RNA|CHCHD3_uc003vrf.2_Silent_p.S56S|CHCHD3_uc010lmj.2_Intron|CHCHD3_uc011kpn.1_Silent_p.S56S	NM_017812	NP_060282	Q9NX63	CHCH3_HUMAN	coiled-coil-helix-coiled-coil-helix domain	56					inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold				0						CAGCAATACCTGAGGCACCAT	0.378													C	132754903	C	C	132754903	2	2	24	1	0	0	0	0	0	0	0	1	3317	1594	55	4		4	CHCHD3	7	132754903	Silent	SNP	T	TCGA-06-0152-01A-02W-0323-08	29416553	132754903	26383760	28	1518											
KEL	3792	broad.mit.edu	37	chr7	142655026	142655026	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gcgttcggttaaagtttaagGaagtccatttaccagagatg	11	6	0	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr7:142655026G>T	uc003wcb.2	-	6	770	c.560C>A	c.(559-561)TCC>TAC	p.S187Y		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	187	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					AAAGTTTAAGGAAGTCCATTT	0.517													T	142655026	T	T	142655026	3	4	24	1	0	0	0	0	1	0	0	0	8142	1174	41	5	1694	5	KEL	7	142655026	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	9900123	142655026	16483637	29	1519											
CLCN1	1180	broad.mit.edu	37	chr7	143036401	143036401	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	accctgcggaggcttcatgcCtgtgtttgtgctaggtaagt	13	9	1	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr7:143036401C>G	uc003wcr.1	+	13	1544	c.1457C>G	c.(1456-1458)CCT>CGT	p.P486R	CLCN1_uc011ktc.1_Missense_Mutation_p.P98R	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	486	Helical; (By similarity).|Selectivity filter part_3 (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					GGCTTCATGCCTGTGTTTGTG	0.517													G	143036401	G	G	143036401	3	3	24	1	0	0	0	0	1	0	0	0	3462	681	24	5	1507	5	CLCN1	7	143036401	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	381375	143036401	16102262	30	1520											
ARHGEF10	9639	broad.mit.edu	37	chr8	1806268	1806268	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtgctggagccagtgaagcCcctgcacccacaggtgagtt	14	12	0	2	rs111294316	byFrequency	TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr8:1806268C>A	uc003wpr.2	+	3	358	c.180C>A	c.(178-180)GCC>GCA	p.A60A	ARHGEF10_uc003wpq.1_Silent_p.A84A|ARHGEF10_uc003wps.2_Silent_p.A60A|ARHGEF10_uc003wpt.2_5'Flank|ARHGEF10_uc010lrd.1_5'Flank|ARHGEF10_uc003wpu.2_5'Flank	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	84					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CCAGTGAAGCCCCTGCACCCA	0.323													A	1806268	A	A	1806268	2	1	24	1	0	0	0	0	0	0	0	1	894	610	22	5		5	ARHGEF10	8	1806268	Silent	SNP	C	TCGA-06-0152-01A-02W-0323-08		1806268	144557754	31	1521											
TRIM55	84675	broad.mit.edu	37	chr8	67062093	67062093	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttcagtttatggatgagccaGaaatggcagtgtttctgcag	12	6	2	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr8:67062093G>T	uc003xvv.2	+	5	1043	c.817G>T	c.(817-819)GAA>TAA	p.E273*	TRIM55_uc003xvu.2_Nonsense_Mutation_p.E273*|TRIM55_uc003xvw.2_Nonsense_Mutation_p.E273*|TRIM55_uc003xvx.2_Intron	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	273	COS.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GGATGAGCCAGAAATGGCAGT	0.378													T	67062093	T	T	67062093	4	4	24	1	0	0	0	0	0	1	0	0	16526	943	33	5	835	5	TRIM55	8	67062093	Nonsense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	65255825	67062093	79301929	32	1522											
DENND4C	55667	broad.mit.edu	37	chr9	19346294	19346294	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgagcacagatcatctcCggtgccagagatgcttgagg	12	11	2	4			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr9:19346294C>T	uc003znq.2	+	18	2705	c.2672C>T	c.(2671-2673)CCG>CTG	p.P891L	DENND4C_uc011lnc.1_Missense_Mutation_p.P221L|DENND4C_uc011lnd.1_Missense_Mutation_p.P179L|DENND4C_uc003znr.2_Missense_Mutation_p.P179L|DENND4C_uc003zns.2_Missense_Mutation_p.P73L|DENND4C_uc003znt.2_Missense_Mutation_p.P73L	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	891						integral to membrane				ovary(1)|skin(1)	2						AGATCATCTCCGGTGCCAGAG	0.443													T	19346294	T	T	19346294	3	4	24	1	0	0	0	0	1	0	0	0	4435	652	23	2	2742	2	DENND4C	9	19346294	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08		19346294	121867137	33	1523											
PGM5	5239	broad.mit.edu	37	chr9	71080089	71080089	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatctgatggactcaggacGttgcaatctgtgtggggaag	14	6	3	1	rs141668530		TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr9:71080089G>A	uc004agr.2	+	7	1353	c.1124G>A	c.(1123-1125)CGT>CAT	p.R375H		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	375					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						GACTCAGGACGTTGCAATCTG	0.473													A	71080089	A	A	71080089	3	1	24	1	0	0	0	0	1	0	0	0	11801	1145	40	1	1150	1	PGM5	9	71080089	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	51733795	71080089	70133342	34	1524											
APBA1	320	broad.mit.edu	37	chr9	72130983	72130983	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggggctaatgtcctggcGcatgacccagatgggctctt	15	10	1	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr9:72130983G>A	uc004ahh.2	-	2	1420	c.1144C>T	c.(1144-1146)CGC>TGC	p.R382C		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	382	LIN-2/CASK binding.|Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						ATGTCCTGGCGCATGACCCAG	0.622													A	72130983	A	A	72130983	3	1	24	1	0	0	0	0	1	0	0	0	756	1087	38	1	1417	1	APBA1	9	72130983	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	1050894	72130983	69082448	35	1525											
GOLGA2	2801	broad.mit.edu	37	chr9	131020819	131020821	+	In_Frame_Del	DEL	TCC	-	-													cctcctcctcctcctcctcaTcctcctcctcctcccggtcc							TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr9:131020819_131020821delTCC	uc011maw.1	-	21	2134_2136	c.2121_2123delGGA	c.(2119-2124)GAGGAT>GAT	p.E707del	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_In_Frame_Del_p.E180del	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	707	Potential.|Poly-Glu.					Golgi cisterna membrane	protein binding			ovary(1)	1						ctcctcctcatcctcctcctcct	0.527													-	131020821	-	-	131020819	7	5	24	1	0	1	0	1	0	0	0	0	6552	1435	50	0	909	0	GOLGA2	9	131020819	In_Frame_Del	DEL	TCC	TCGA-06-0152-01A-02W-0323-08	58889836	131020819	10192612	36	1526											
SOHLH1	402381	broad.mit.edu	37	chr9	138586907	138586907	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcactcacccggcctcctgCgccagcatggggtcctcctt	11	18	1	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr9:138586907C>T	uc004cgl.2	-	6	925	c.864G>A	c.(862-864)GCG>GCA	p.A288A	SOHLH1_uc010nbe.2_Silent_p.A288A	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	288					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		CGGCCTCCTGCGCCAGCATGG	0.697													T	138586907	T	T	138586907	2	4	24	1	0	0	0	0	0	0	0	1	14923	755	27	1		1	SOHLH1	9	138586907	Silent	SNP	C	TCGA-06-0152-01A-02W-0323-08	7566088	138586907	2626524	37	1527											
KIAA1217	56243	broad.mit.edu	37	chr10	24762771	24762771	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgaggatgatagacatgcaCgctcactataatgcccacgg	10	11	1	3	rs143282203	byFrequency	TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr10:24762771C>T	uc001iru.3	+	6	1864	c.1461C>T	c.(1459-1461)CAC>CAT	p.H487H	KIAA1217_uc001irs.2_Silent_p.H407H|KIAA1217_uc001irt.3_Silent_p.H487H|KIAA1217_uc010qcy.1_Silent_p.H487H|KIAA1217_uc010qcz.1_Silent_p.H487H|KIAA1217_uc001irv.1_Silent_p.H337H|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Silent_p.H205H|KIAA1217_uc001irz.2_Silent_p.H205H|KIAA1217_uc001irx.2_Silent_p.H205H|KIAA1217_uc001iry.2_Silent_p.H205H	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	487					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						TAGACATGCACGCTCACTATA	0.557													T	24762771	T	T	24762771	2	4	24	1	0	0	0	0	0	0	0	1	8216	535	19	1		1	KIAA1217	10	24762771	Silent	SNP	C	TCGA-06-0152-01A-02W-0323-08		24762771	110771976	38	1528											
KIAA1462	57608	broad.mit.edu	37	chr10	30315407	30315407	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttcagagcctgccacacttgGggttctttctacaaaatgga	9	10	3	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr10:30315407G>C	uc001iux.2	-	2	3729	c.3670C>G	c.(3670-3672)CCA>GCA	p.P1224A	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.P1086A|KIAA1462_uc009xle.1_Missense_Mutation_p.P1224A	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1224										ovary(4)	4						GCCACACTTGGGGTTCTTTCT	0.488													C	30315407	C	C	30315407	3	2	24	1	0	0	0	0	1	0	0	0	8234	1232	43	5	417	5	KIAA1462	10	30315407	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	5552636	30315407	105219340	39	1529											
DOCK1	1793	broad.mit.edu	37	chr10	129231688	129231688	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ccccttccagaccaggctccGacgggtgagtcaagctcaca	10	16	2	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr10:129231688G>T	uc001ljt.2	+	48	5057	c.4993G>T	c.(4993-4995)GAC>TAC	p.D1665Y	DOCK1_uc010qun.1_Missense_Mutation_p.D1686Y|DOCK1_uc009yaq.2_Missense_Mutation_p.D660Y	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1665					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding	p.D1665Y(1)		central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		ACCAGGCTCCGACGGGTGAGT	0.597													T	129231688	T	T	129231688	3	4	24	1	0	0	0	0	1	0	0	0	4684	1058	37	5	5183	5	DOCK1	10	129231688	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	98916281	129231688	6303059	40	1530											
NELL1	4745	broad.mit.edu	37	chr11	20949959	20949959	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgaaggatgtcctgtcccCctctcaattgctccccagac	8	17	1	1	rs150066751		TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr11:20949959C>T	uc001mqe.2	+	9	1084	c.931C>T	c.(931-933)CCT>TCT	p.P311S	NELL1_uc001mqf.2_Missense_Mutation_p.P311S|NELL1_uc009yid.2_Missense_Mutation_p.P339S|NELL1_uc010rdo.1_Missense_Mutation_p.P254S|NELL1_uc010rdp.1_Missense_Mutation_p.P71S	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	311	VWFC 1.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GTCCTGTCCCCCTCTCAATTG	0.537													T	20949959	T	T	20949959	3	4	24	1	0	0	0	0	1	0	0	0	10333	623	22	3	965	3	NELL1	11	20949959	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08		20949959	114056557	41	1531											
PACS1	55690	broad.mit.edu	37	chr11	65988123	65988123	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggctttgggctggagcatGtgtcccgcgagcagatccgg	17	10	0	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr11:65988123G>A	uc001oha.1	+	9	1194	c.1060G>A	c.(1060-1062)GTG>ATG	p.V354M		NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	354	Potential.				interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						GCTGGAGCATGTGTCCCGCGA	0.517													A	65988123	A	A	65988123	3	1	24	1	0	0	0	0	1	0	0	0	11372	1377	48	3	1094	3	PACS1	11	65988123	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	45038164	65988123	69018393	42	1532											
PRMT8	56341	broad.mit.edu	37	chr12	3649947	3649947	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgactcctatgcccactttgGgatccacgaggtaaagtgtc	10	12	0	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr12:3649947G>T	uc001qmf.2	+	2	618	c.251G>T	c.(250-252)GGG>GTG	p.G84V	PRMT8_uc009zed.2_Missense_Mutation_p.G75V|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	84					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			GCCCACTTTGGGATCCACGAG	0.532													T	3649947	T	T	3649947	3	4	24	1	0	0	0	0	1	0	0	0	12542	1232	43	5	257	5	PRMT8	12	3649947	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08		3649947	130201948	43	1533											
TMEM132D	121256	broad.mit.edu	37	chr12	129694197	129694197	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtgaggatggctgtgttcagGatttctgcctcctggaagac	14	8	2	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr12:129694197G>A	uc009zyl.1	-	5	1639	c.1311C>T	c.(1309-1311)ATC>ATT	p.I437I		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	437	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTGTGTTCAGGATTTCTGCCT	0.617													A	129694197	A	A	129694197	2	1	24	1	0	0	0	0	0	0	0	1	16044	1164	41	3		3	TMEM132D	12	129694197	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08	126044250	129694197	4157698	44	1534											
MTUS2	23281	broad.mit.edu	37	chr13	29599308	29599308	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaaattccccggcatgTtcccaaggataaactggcaa	9	11	0	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr13:29599308T>C	uc001usl.3	+	1	561	c.503T>C	c.(502-504)GTT>GCT	p.V168A		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	158						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						CCCCGGCATGTTCCCAAGGAT	0.507													C	29599308	C	C	29599308	3	2	24	1	0	0	0	0	1	0	0	0	9966	1725	60	4	505	4	MTUS2	13	29599308	Missense_Mutation	SNP	T	TCGA-06-0152-01A-02W-0323-08		29599308	85570570	45	1535											
SLITRK6	84189	broad.mit.edu	37	chr13	86370526	86370526	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tattagcattgtgccatcttTttcctcacaattgcaaagag	6	9	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr13:86370526T>G	uc001vll.1	-	2	577	c.118A>C	c.(118-120)AAA>CAA	p.K40Q	SLITRK6_uc010afe.1_5'Flank	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	40	LRRNT 1.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GTGCCATCTTTTTCCTCACAA	0.388													G	86370526	G	G	86370526	3	3	24	1	0	0	0	0	1	0	0	0	14747	1850	64	5	2411	5	SLITRK6	13	86370526	Missense_Mutation	SNP	T	TCGA-06-0152-01A-02W-0323-08	56771218	86370526	28799352	46	1536											
FOXA1	3169	broad.mit.edu	37	chr14	38060897	38060897	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcacagaggccagcgccccGggcccggagcttatgggggg	19	13	0	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr14:38060897G>A	uc001wuf.2	-	2	1404	c.1092C>T	c.(1090-1092)CCC>CCT	p.P364P	FOXA1_uc010tpz.1_Silent_p.P331P	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	364					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		CCAGCGCCCCGGGCCCGGAGC	0.697													A	38060897	A	A	38060897	2	1	24	1	0	0	0	0	0	0	0	1	5989	1103	39	2		2	FOXA1	14	38060897	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08		38060897	69288643	47	1537											
SIPA1L1	26037	broad.mit.edu	37	chr14	72055586	72055586	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtccaaagtgctttgccCactatgatgtccagagtata	8	10	0	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr14:72055586C>T	uc001xms.2	+	2	1345	c.997C>T	c.(997-999)CAC>TAC	p.H333Y	SIPA1L1_uc001xmt.2_Missense_Mutation_p.H333Y|SIPA1L1_uc001xmu.2_Missense_Mutation_p.H333Y|SIPA1L1_uc001xmv.2_Missense_Mutation_p.H333Y	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	333					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GTGCTTTGCCCACTATGATGT	0.448													T	72055586	T	T	72055586	3	4	24	1	0	0	0	0	1	0	0	0	14329	594	21	3	999	3	SIPA1L1	14	72055586	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	33994689	72055586	35293954	48	1538											
FAM181A	90050	broad.mit.edu	37	chr14	94394688	94394688	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgtgaacctggcgtccagCgacatcaaggcagccctgga	12	13	1	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr14:94394688C>T	uc001ybz.1	+	3	550	c.243C>T	c.(241-243)AGC>AGT	p.S81S	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Silent_p.S19S|FAM181A_uc001yca.1_Silent_p.S19S	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	81											0						TGGCGTCCAGCGACATCAAGG	0.587													T	94394688	T	T	94394688	2	4	24	1	0	0	0	0	0	0	0	1	5508	767	27	1		1	FAM181A	14	94394688	Silent	SNP	C	TCGA-06-0152-01A-02W-0323-08	22339102	94394688	12954852	49	1539											
SERPINA11	256394	broad.mit.edu	37	chr14	94914503	94914503	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taattggcaagaaccatgaaCgtgtcctggctgaactccgg	11	10	0	3			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr14:94914503C>T	uc001ydd.1	-	2	669	c.609G>A	c.(607-609)ACG>ACA	p.T203T		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	203					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		GAACCATGAACGTGTCCTGGC	0.473													T	94914503	T	T	94914503	2	4	24	1	0	0	0	0	0	0	0	1	14088	523	19	1		1	SERPINA11	14	94914503	Silent	SNP	C	TCGA-06-0152-01A-02W-0323-08	519815	94914503	12435037	50	1540											
RYR3	6263	broad.mit.edu	37	chr15	34077951	34077951	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaaatcaacgacctggccgaGtcaggggcccggtacacaga	13	12	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr15:34077951G>T	uc001zhi.2	+	66	9427	c.9357G>T	c.(9355-9357)GAG>GAT	p.E3119D	RYR3_uc010bar.2_Missense_Mutation_p.E3119D	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3119					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACCTGGCCGAGTCAGGGGCCC	0.567													T	34077951	T	T	34077951	3	4	24	1	0	0	0	0	1	0	0	0	13770	1020	36	5	9619	5	RYR3	15	34077951	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08		34077951	68453441	51	1541											
TYRO3	7301	broad.mit.edu	37	chr15	41860451	41860451	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaaaacctccatgccatccGcacagattcaggcctcatct	5	17	3	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr15:41860451G>A	uc001zof.1	+	8	1222	c.998G>A	c.(997-999)CGC>CAC	p.R333H		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	333	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CATGCCATCCGCACAGATTCA	0.562													A	41860451	A	A	41860451	3	1	24	1	0	0	0	0	1	0	0	0	16811	1087	38	1	1028	1	TYRO3	15	41860451	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	7782500	41860451	60670941	52	1542											
CCDC33	80125	broad.mit.edu	37	chr15	74554903	74554903	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagatccaagctgaggatgCagggcaagaaggtaagcagg	17	6	0	3			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr15:74554903C>T	uc002axo.2	+	3	702	c.308C>T	c.(307-309)GCA>GTA	p.A103V		NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	306	C2.						protein binding			ovary(3)|skin(2)	5						GCTGAGGATGCAGGGCAAGAA	0.587													T	74554903	T	T	74554903	3	4	24	1	0	0	0	0	1	0	0	0	2806	710	25	3	318	3	CCDC33	15	74554903	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	32694452	74554903	27976489	53	1543											
BCL2A1	597	broad.mit.edu	37	chr15	80263133	80263133	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttataggtatccacatccGgggcaatttgctgtcgtaga	10	10	0	1	rs143571009		TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr15:80263133G>A	uc002bfc.3	-	1	511	c.329C>T	c.(328-330)CCG>CTG	p.P110L	BCL2A1_uc002bfd.3_Missense_Mutation_p.P110L	NM_004049	NP_004040	Q16548	B2LA1_HUMAN	BCL2-related protein A1 isoform 1	110					anti-apoptosis|apoptosis	cytoplasm	protein binding			pancreas(1)	1						ATCCACATCCGGGGCAATTTG	0.403													A	80263133	A	A	80263133	3	1	24	1	0	0	0	0	1	0	0	0	1366	1116	39	2	266	2	BCL2A1	15	80263133	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	5708230	80263133	22268259	54	1544											
ALPK3	57538	broad.mit.edu	37	chr15	85400203	85400203	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccccaaactcccacctacagCgggtcctagagctcctctga	7	18	1	2	rs142677464		TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr15:85400203C>A	uc002ble.2	+	6	3007	c.2840C>A	c.(2839-2841)GCG>GAG	p.A947E		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	947					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCACCTACAGCGGGTCCTAGA	0.562													A	85400203	A	A	85400203	3	1	24	1	0	0	0	0	1	0	0	0	546	768	27	5	2862	5	ALPK3	15	85400203	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	5137070	85400203	17131189	55	1545											
PEX11A	8800	broad.mit.edu	37	chr15	90226684	90226684	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aggacacaagacctccaagtCcaatgatgccaggattggat	10	10	0	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr15:90226684C>T	uc002boi.2	-	3	763	c.668G>A	c.(667-669)GGA>GAA	p.G223E	PEX11A_uc010upy.1_RNA	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	223	Helical; (Potential).				cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			ACCTCCAAGTCCAATGATGCC	0.483													T	90226684	T	T	90226684	3	4	24	1	0	0	0	0	1	0	0	0	11737	855	30	3	79	3	PEX11A	15	90226684	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	4826481	90226684	12304708	56	1546											
ALG1	56052	broad.mit.edu	37	chr16	5128838	5128838	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggctggtgacgcgtctccGtgagcggccagccctgctgg	17	14	1	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr16:5128838G>A	uc002cym.2	+	7	862	c.821G>A	c.(820-822)CGT>CAT	p.R274H	ALG1_uc002cyj.2_Missense_Mutation_p.R163H|ALG1_uc002cyn.2_Missense_Mutation_p.R274H|ALG1_uc010bue.2_Missense_Mutation_p.R163H|ALG1_uc010uxy.1_Missense_Mutation_p.R163H	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	274	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				ACGCGTCTCCGTGAGCGGCCA	0.652													A	5128838	A	A	5128838	3	1	24	1	0	0	0	0	1	0	0	0	510	1145	40	1	847	1	ALG1	16	5128838	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08		5128838	85225915	57	1547											
TAX1BP3	30851	broad.mit.edu	37	chr17	3567085	3567085	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggccttctgcagcgactgcCgcgtcaccagcagacgcacc	11	18	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr17:3567085C>T	uc002fwc.2	-	4	485	c.332G>A	c.(331-333)CGG>CAG	p.R111Q	P2RX5_uc002fwd.2_RNA|TAX1BP3_uc002fwe.1_3'UTR	NM_014604	NP_055419	O14907	TX1B3_HUMAN	Tax1 binding protein 3	111	PDZ.				activation of Cdc42 GTPase activity|negative regulation of protein localization at cell surface|negative regulation of Wnt receptor signaling pathway|Rho protein signal transduction|Wnt receptor signaling pathway	cytoplasm|nucleus	protein C-terminus binding				0				COAD - Colon adenocarcinoma(5;0.0761)		CAGCGACTGCCGCGTCACCAG	0.647													T	3567085	T	T	3567085	3	4	24	1	0	0	0	0	1	0	0	0	15592	652	23	2	46	2	TAX1BP3	17	3567085	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08		3567085	77628125	58	1548											
ENO3	2027	broad.mit.edu	37	chr17	4860277	4860277	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttgcctgcattctaggatcGaggaggctcttggggacaag	14	9	2	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr17:4860277G>A	uc002gab.3	+	12	1334	c.1240G>A	c.(1240-1242)GAG>AAG	p.E414K	ENO3_uc002gac.3_Missense_Mutation_p.E414K|ENO3_uc010vss.1_Missense_Mutation_p.E371K|ENO3_uc010vst.1_Missense_Mutation_p.E241K	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	414					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1						TTCTAGGATCGAGGAGGCTCT	0.577											OREG0024110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	4860277	A	A	4860277	3	1	24	1	0	0	0	0	1	0	0	0	5123	1059	37	2	1282	2	ENO3	17	4860277	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	1293192	4860277	76334933	59	1549											
ALOX12B	242	broad.mit.edu	37	chr17	7984477	7984477	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttctgtgctccaggaggacGgggagcgagtcatctgctgt	15	9	3	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr17:7984477G>A	uc002gjy.1	-	3	642	c.381C>T	c.(379-381)CCC>CCT	p.P127P	uc010cnq.1_RNA	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	127	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						CCAGGAGGACGGGGAGCGAGT	0.617										Multiple Myeloma(8;0.094)			A	7984477	A	A	7984477	2	1	24	1	0	0	0	0	0	0	0	1	537	1103	39	2		2	ALOX12B	17	7984477	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08	3124200	7984477	73210733	60	1550											
USH1G	124590	broad.mit.edu	37	chr17	72916074	72916074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggctcggccgccagcgtgGcacgggagacgctgtcctcg	16	15	0	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr17:72916074G>A	uc002jme.1	-	2	1040	c.857C>T	c.(856-858)GCC>GTC	p.A286V	USH1G_uc010wro.1_Missense_Mutation_p.A183V	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	286					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					CGCCAGCGTGGCACGGGAGAC	0.687													A	72916074	A	A	72916074	3	1	24	1	0	0	0	0	1	0	0	0	17032	1203	42	3	536	3	USH1G	17	72916074	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	64931597	72916074	8279136	61	1551											
FOXJ1	2302	broad.mit.edu	37	chr17	74136123	74136123	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagtagggaggcttcacgtgCggattggtggcgtagtccac	17	8	1	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr17:74136123C>A	uc002jqw.2	-	1	444	c.354G>T	c.(352-354)CCG>CCT	p.P118P	FOXJ1_uc002jqx.2_Silent_p.P118P|uc002jqy.1_5'Flank	NM_001454	NP_001445	Q92949	FOXJ1_HUMAN	forkhead box J1	118					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			pancreas(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			GCTTCACGTGCGGATTGGTGG	0.667													A	74136123	A	A	74136123	2	1	24	1	0	0	0	0	0	0	0	1	6011	755	27	5		5	FOXJ1	17	74136123	Silent	SNP	C	TCGA-06-0152-01A-02W-0323-08	1220049	74136123	7059087	62	1552											
FAM59A	64762	broad.mit.edu	37	chr18	29890192	29890192	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atatcctccatgacgtacacGcgttcaggaaatgccttagc	8	12	1	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr18:29890192G>A	uc002kxl.2	-	3	413	c.357C>T	c.(355-357)CGC>CGT	p.R119R	FAM59A_uc002kxk.1_Silent_p.R119R	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	119	CABIT.									ovary(1)|skin(1)	2						TGACGTACACGCGTTCAGGAA	0.413													A	29890192	A	A	29890192	2	1	24	1	0	0	0	0	0	0	0	1	5592	1074	38	1		1	FAM59A	18	29890192	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08		29890192	48187056	63	1553											
SERPINB5	5268	broad.mit.edu	37	chr18	61156656	61156656	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaagataaattggaagaaaCgaaaggtcagatcaacaact	8	6	2	3	rs145559318		TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr18:61156656C>T	uc002liz.3	+	4	525	c.383C>T	c.(382-384)ACG>ATG	p.T128M	SERPINB5_uc002liy.2_Missense_Mutation_p.T128M	NM_002639	NP_002630	P36952	SPB5_HUMAN	serine (or cysteine) proteinase inhibitor, clade	128					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1						TTGGAAGAAACGAAAGGTCAG	0.388													T	61156656	T	T	61156656	3	4	24	1	0	0	0	0	1	0	0	0	14104	536	19	1	393	1	SERPINB5	18	61156656	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	31266464	61156656	16920592	64	1554											
MUC16	94025	broad.mit.edu	37	chr19	9067989	9067989	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctctactcgtaagagtggacAaatctaattgtgaaaatcca	7	8	2	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr19:9067989A>G	uc002mkp.2	-	3	19661	c.19457T>C	c.(19456-19458)TTG>TCG	p.L6486S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6488	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAGAGTGGACAAATCTAATTG	0.488													G	9067989	G	G	9067989	3	3	24	1	0	0	0	0	1	0	0	0	9973	131	5	4	24394	4	MUC16	19	9067989	Missense_Mutation	SNP	A	TCGA-06-0152-01A-02W-0323-08		9067989	50060994	65	1555											
SLC44A2	57153	broad.mit.edu	37	chr19	10742381	10742381	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagacgacctatgaggatggGcatggctcccggaaaaacat	13	9	0	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr19:10742381G>A	uc002mpf.2	+	8	721	c.582G>A	c.(580-582)GGG>GGA	p.G194G	SLC44A2_uc002mpe.3_Silent_p.G192G	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	194	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	ATGAGGATGGGCATGGCTCCC	0.602													A	10742381	A	A	10742381	2	1	24	1	0	0	0	0	0	0	0	1	14636	1190	42	3		3	SLC44A2	19	10742381	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08	1674392	10742381	48386602	66	1556											
PSG7	5676	broad.mit.edu	37	chr19	43429925	43429925	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggatgctgggatccacttacCagagactctgactgtcacgg	12	11	2	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr19:43429925C>A	uc002ovl.3	-	6	1345	c.1243G>T	c.(1243-1245)GAC>TAC	p.D415Y	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Missense_Mutation_p.A328S|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Missense_Mutation_p.A141S|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.D328Y|PSG7_uc010xwl.1_Missense_Mutation_p.D293Y	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	415					female pregnancy	extracellular region					0		Prostate(69;0.00682)				ATCCACTTACCAGAGACTCTG	0.483													A	43429925	A	A	43429925	3	1	24	1	0	0	0	0	1	0	0	0	12660	608	21	5	24	5	PSG7	19	43429925	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	32687544	43429925	15699058	67	1557											
ZNF45	7596	broad.mit.edu	37	chr19	44417709	44417709	+	Frame_Shift_Del	DEL	G	-	-													aactctttgatgggcttgaaGgtatgagctccagctgaaga							TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr19:44417709delG	uc002oxu.1	-	4	1978	c.1879delC	c.(1879-1881)CTTfs	p.L627fs	ZNF45_uc002oxw.1_Frame_Shift_Del_p.L627fs|ZNF45_uc002oxv.1_Frame_Shift_Del_p.L627fs	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	627	C2H2-type 17.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGGGCTTGAAGGTATGAGCTC	0.488													-	44417709	-	-	44417709	7	5	24	1	0	1	0	1	0	0	0	0	17918	1000	35	0	173	0	ZNF45	19	44417709	Frame_Shift_Del	DEL	G	TCGA-06-0152-01A-02W-0323-08	987784	44417709	14711274	68	1558											
CEACAM20	125931	broad.mit.edu	37	chr19	45029207	45029207	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaacatcctcactttgggtGgcatcaagtgggttggcatt	11	9	2	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr19:45029207G>A	uc010ejn.1	-	2	139	c.123C>T	c.(121-123)GCC>GCT	p.A41A	CEACAM20_uc010ejo.1_Silent_p.A41A|CEACAM20_uc010ejp.1_Silent_p.A41A|CEACAM20_uc010ejq.1_Silent_p.A41A	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	41	Extracellular (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				CACTTTGGGTGGCATCAAGTG	0.562													A	45029207	A	A	45029207	2	1	24	1	0	0	0	0	0	0	0	1	3191	1335	47	3		3	CEACAM20	19	45029207	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08	611498	45029207	14099776	69	1559											
ZNF83	55769	broad.mit.edu	37	chr19	53116375	53116375	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttacatttgaaatgtttctcTccagtgtggatcgcatgatg	9	7	1	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr19:53116375T>C	uc002pzu.3	-	2	2687	c.1443A>G	c.(1441-1443)GGA>GGG	p.G481G	ZNF83_uc002pzv.3_Silent_p.G481G|ZNF83_uc010eps.2_Silent_p.G453G|ZNF83_uc010ept.2_Silent_p.G481G|ZNF83_uc010epu.2_Silent_p.G481G|ZNF83_uc010epv.2_Silent_p.G481G|ZNF83_uc010epw.2_Silent_p.G481G|ZNF83_uc010epx.2_Silent_p.G453G|ZNF83_uc010epy.2_Silent_p.G481G|ZNF83_uc010epz.2_Silent_p.G453G	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	481						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		AATGTTTCTCTCCAGTGTGGA	0.388													C	53116375	C	C	53116375	2	2	24	1	0	0	0	0	0	0	0	1	18180	1538	54	4		4	ZNF83	19	53116375	Silent	SNP	T	TCGA-06-0152-01A-02W-0323-08	8087168	53116375	6012608	70	1560											
TMC4	147798	broad.mit.edu	37	chr19	54669199	54669199	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggcgcagccgcacgtggacgTccccgcagagaccgaagtcc	14	16	0	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr19:54669199T>G	uc010erf.2	-	6	1049	c.917A>C	c.(916-918)GAC>GCC	p.D306A	TMC4_uc002qdn.2_5'Flank|TMC4_uc002qdo.2_Missense_Mutation_p.D300A	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	306	Extracellular (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CACGTGGACGTCCCCGCAGAG	0.632													G	54669199	G	G	54669199	3	3	24	1	0	0	0	0	1	0	0	0	15984	1667	58	5	1261	5	TMC4	19	54669199	Missense_Mutation	SNP	T	TCGA-06-0152-01A-02W-0323-08	1552824	54669199	4459784	71	1561											
NLRP9	338321	broad.mit.edu	37	chr19	56244390	56244390	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctaatgcaataaggagagaGgattctggaagcatcttttt	10	6	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr19:56244390G>A	uc002qly.2	-	2	835	c.807C>T	c.(805-807)TCC>TCT	p.S269S		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	269	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TAAGGAGAGAGGATTCTGGAA	0.408													A	56244390	A	A	56244390	2	1	24	1	0	0	0	0	0	0	0	1	10484	987	35	3		3	NLRP9	19	56244390	Silent	SNP	G	TCGA-06-0152-01A-02W-0323-08	1575191	56244390	2884593	72	1562											
PLCB1	23236	broad.mit.edu	37	chr20	8352082	8352082	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgccagatgtgggagacaCgccaaagctcccaaggtagg	14	10	0	2			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr20:8352082C>T	uc002wnb.2	+	3	234	c.231C>T	c.(229-231)CAC>CAT	p.H77H	PLCB1_uc010zrb.1_Translation_Start_Site|PLCB1_uc010gbv.1_Silent_p.H77H|PLCB1_uc002wmz.1_Silent_p.H77H|PLCB1_uc002wna.2_Silent_p.H77H	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	77					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GTGGGAGACACGCCAAAGCTC	0.468													T	8352082	T	T	8352082	2	4	24	1	0	0	0	0	0	0	0	1	12027	535	19	1		1	PLCB1	20	8352082	Silent	SNP	C	TCGA-06-0152-01A-02W-0323-08		8352082	54673438	73	1563											
SSTR4	6754	broad.mit.edu	37	chr20	23016952	23016952	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctggatgcctttctacgtgGtgcagctgctgaacctcttc	11	12	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr20:23016952G>T	uc002wsr.2	+	1	896	c.832G>T	c.(832-834)GTG>TTG	p.V278L		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	278	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TTTCTACGTGGTGCAGCTGCT	0.577													T	23016952	T	T	23016952	3	4	24	1	0	0	0	0	1	0	0	0	15199	1261	44	5	834	5	SSTR4	20	23016952	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	14664870	23016952	40008568	74	1564											
PREX1	57580	broad.mit.edu	37	chr20	47244458	47244458	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcagcaacccgtggctccGtgccaagatggccgcctgct	14	15	0	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr20:47244458G>A	uc002xtw.1	-	38	4833	c.4810C>T	c.(4810-4812)CGG>TGG	p.R1604W	PREX1_uc002xtv.1_Missense_Mutation_p.R901W	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1604					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCGTGGCTCCGTGCCAAGATG	0.692													A	47244458	A	A	47244458	3	1	24	1	0	0	0	0	1	0	0	0	12476	1144	40	1	181	1	PREX1	20	47244458	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	24227506	47244458	15781062	75	1565											
KCNG1	3755	broad.mit.edu	37	chr20	49621144	49621144	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcccgcgccgggcttgcgaCggcctgcggcggcgccgtcc	17	18	0	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr20:49621144C>T	uc002xwa.3	-	3	1269	c.974G>A	c.(973-975)CGT>CAT	p.R325H		NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	325						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						GGGCTTGCGACGGCCTGCGGC	0.701													T	49621144	T	T	49621144	3	4	24	1	0	0	0	0	1	0	0	0	8027	536	19	1	571	1	KCNG1	20	49621144	Missense_Mutation	SNP	C	TCGA-06-0152-01A-02W-0323-08	2376686	49621144	13404376	76	1566											
SCARF2	91179	broad.mit.edu	37	chr22	20784714	20784714	+	Splice_Site	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcccggtcccggggcactcActggggcccgtggacgccag	15	17	1	0			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr22:20784714A>C	uc002zsj.1	-	6	1307	c.1202_splice	c.e6+1	p.H401_splice	SCARF2_uc002zsk.1_Splice_Site_p.H401_splice	NM_153334	NP_699165	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2 isoform 1						cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CGGGGCACTCACTGGGGCCCG	0.711													C	20784714	C	C	20784714	5	2	24	1	0	0	0	0	0	0	1	0	13884	173	6	5	1432	5	SCARF2	22	20784714	Splice_Site	SNP	A	TCGA-06-0152-01A-02W-0323-08		20784714	30519852	77	1567											
CACNA1I	8911	broad.mit.edu	37	chr22	40078576	40078576	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccccttgtcctctacggccGtctcgccggatccagagaac	9	17	2	1			TCGA-06-0152-01A-02W-0323-08	TCGA-06-0152-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	79062efd-2b09-4798-a504-0a18ca30ef2d	eb4aaeef-72d7-4da6-96d9-7504521a99f1	g.chr22:40078576G>A	uc003ayc.2	+	35	5740	c.5740G>A	c.(5740-5742)GTC>ATC	p.V1914I	CACNA1I_uc003ayd.2_Missense_Mutation_p.V1879I|CACNA1I_uc003aye.2_Missense_Mutation_p.V1829I|CACNA1I_uc003ayf.2_Missense_Mutation_p.V1794I	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1914	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CTCTACGGCCGTCTCGCCGGA	0.592													A	40078576	A	A	40078576	3	1	24	1	0	0	0	0	1	0	0	0	2546	1145	40	1	5878	1	CACNA1I	22	40078576	Missense_Mutation	SNP	G	TCGA-06-0152-01A-02W-0323-08	19293862	40078576	11225990	78	1568											
CLCNKA	1187	broad.mit.edu	37	chr1	16355293	16355293	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctggccaccttgcttctcGcctccatcacctacccgcct	5	21	3	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:16355293G>A	uc001axu.2	+	11	1086	c.1006G>A	c.(1006-1008)GCC>ACC	p.A336T	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.A336T|CLCNKA_uc010obw.1_Missense_Mutation_p.A293T|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010obx.1_5'UTR|CLCNKA_uc010oby.1_Missense_Mutation_p.R65H	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	336	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CTTGCTTCTCGCCTCCATCAC	0.632													A	16355293	A	A	16355293	3	1	25	1	0	0	0	0	1	0	0	0	3469	1087	38	1	1044	1	CLCNKA	1	16355293	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08		16355293	232895328	1	1569											
LRRC7	57554	broad.mit.edu	37	chr1	70503971	70503971	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagggtttgttgctgaggaaAccacagccgagaatgccaac	12	10	0	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:70503971A>G	uc001dep.2	+	19	2380	c.2350A>G	c.(2350-2352)ACC>GCC	p.T784A	LRRC7_uc009wbg.2_Missense_Mutation_p.T68A|LRRC7_uc001deq.2_Missense_Mutation_p.T25A	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	784						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TGCTGAGGAAACCACAGCCGA	0.488													G	70503971	G	G	70503971	3	3	25	1	0	0	0	0	1	0	0	0	9020	43	2	4	2424	4	LRRC7	1	70503971	Missense_Mutation	SNP	A	TCGA-06-0154-01A-03D-1491-08	54148678	70503971	178746650	2	1570											
MCOLN3	55283	broad.mit.edu	37	chr1	85499910	85499910	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcataagcatgattcccaaCggagacattgtatagctgca	8	10	1	2	rs144793042	byFrequency	TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:85499910C>T	uc001dkp.2	-	4	514	c.421G>A	c.(421-423)GTT>ATT	p.V141I	MCOLN3_uc001dkq.2_Missense_Mutation_p.V85I|MCOLN3_uc001dkr.2_Missense_Mutation_p.V141I|MCOLN3_uc001dks.3_5'UTR	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	141						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		TGATTCCCAACGGAGACATTG	0.468													T	85499910	T	T	85499910	3	4	25	1	0	0	0	0	1	0	0	0	9397	536	19	1	1280	1	MCOLN3	1	85499910	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	14995939	85499910	163750711	3	1571											
RPL5	6125	broad.mit.edu	37	chr1	93301746	93301746	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttacattggtttcttgaataGcttctcaataggtttggcat	8	6	2	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:93301746G>C	uc001doz.2	+	5	403	c.325_splice	c.e5-1	p.L109_splice	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_Intron|RPL5_uc001dpb.2_Splice_Site_p.L59_splice|RPL5_uc001dpd.2_5'Flank|SNORD21_uc001dpe.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5						endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		TTCTTGAATAGCTTCTCAATA	0.398													C	93301746	C	C	93301746	5	2	25	1	0	0	0	0	0	0	1	0	13597	985	34	5	342	5	RPL5	1	93301746	Splice_Site	SNP	G	TCGA-06-0154-01A-03D-1491-08	7801836	93301746	155948875	4	1572											
C1orf161	126868	broad.mit.edu	37	chr1	116675825	116675825	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcagcaaagcatttctgCgcctggtgaggaaactgcac	10	11	3	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:116675825C>T	uc001egc.1	+	7	1193	c.928C>T	c.(928-930)CGC>TGC	p.R310C		NM_152367	NP_689580	Q8N8X9	MB213_HUMAN	hypothetical protein LOC126868	310											0	Lung SC(450;0.184)	all_cancers(81;0.00142)|all_lung(203;0.000139)|all_epithelial(167;0.000401)|Lung NSC(69;0.000705)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		AGCATTTCTGCGCCTGGTGAG	0.507													T	116675825	T	T	116675825	3	4	25	1	0	0	0	0	1	0	0	0	2009	768	27	1	950	1	C1orf161	1	116675825	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	23374079	116675825	132574796	5	1573											
ADAMTSL4	54507	broad.mit.edu	37	chr1	150530514	150530514	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cggcaggaatttggggggggTggctcctcggtgcccccgga	19	11	0	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:150530514T>G	uc001eux.2	+	14	2507	c.2271T>G	c.(2269-2271)GGT>GGG	p.G757G	ADAMTSL4_uc001euw.2_Silent_p.G757G|ADAMTSL4_uc009wlw.2_Silent_p.G780G|ADAMTSL4_uc010pcg.1_Silent_p.G718G|ADAMTSL4_uc009wlx.2_5'UTR	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	757	TSP type-1 2.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TTGGGGGGGGTGGCTCCTCGG	0.692													G	150530514	G	G	150530514	2	3	25	1	0	0	0	0	0	0	0	1	277	1683	59	5		5	ADAMTSL4	1	150530514	Silent	SNP	T	TCGA-06-0154-01A-03D-1491-08	33854689	150530514	98720107	6	1574											
FLG	2312	broad.mit.edu	37	chr1	152283083	152283083	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcccctgactggccacgtgCggactctttgtggctctgct	11	14	2	1	rs148844389	byFrequency	TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:152283083C>T	uc001ezu.1	-	3	4315	c.4279G>A	c.(4279-4281)GCA>ACA	p.A1427T	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1427	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCCACGTGCGGACTCTTTG	0.557									Ichthyosis				T	152283083	T	T	152283083	3	4	25	1	0	0	0	0	1	0	0	0	5922	768	27	1	7910	1	FLG	1	152283083	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	1752569	152283083	96967538	7	1575											
F5	2153	broad.mit.edu	37	chr1	169510563	169510563	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	agttctggagagaggtttgtCtggctgaggtctaaagaaag	15	4	3	3			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:169510563C>G	uc001ggg.1	-	13	3910	c.3765G>C	c.(3763-3765)CAG>CAC	p.Q1255H		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1255	2-8.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AGAGGTTTGTCTGGCTGAGGT	0.522													G	169510563	G	G	169510563	3	3	25	1	0	0	0	0	1	0	0	0	5348	912	32	5	2961	5	F5	1	169510563	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	17227480	169510563	79740058	8	1576											
OBSCN	84033	broad.mit.edu	37	chr1	228467603	228467603	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcctgtcctgcgacttccGgccagcccccaaggctgtgc	12	17	0	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:228467603G>A	uc009xez.1	+	28	7522	c.7478G>A	c.(7477-7479)CGG>CAG	p.R2493Q	OBSCN_uc001hsn.2_Missense_Mutation_p.R2493Q|OBSCN_uc001hsp.1_Missense_Mutation_p.R192Q|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2493	Ig-like 24.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGCGACTTCCGGCCAGCCCCC	0.622													A	228467603	A	A	228467603	3	1	25	1	0	0	0	0	1	0	0	0	10812	1116	39	2	7584	2	OBSCN	1	228467603	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	58957040	228467603	20783018	9	1577											
RYR2	6262	broad.mit.edu	37	chr1	237924281	237924281	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgacctaaatgcatttgagcGacaaaacaaagctgaaggtc	9	8	0	3			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr1:237924281G>A	uc001hyl.1	+	84	11549	c.11429G>A	c.(11428-11430)CGA>CAA	p.R3810Q	RYR2_uc010pya.1_Missense_Mutation_p.R225Q	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3810					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCATTTGAGCGACAAAACAAA	0.393													A	237924281	A	A	237924281	3	1	25	1	0	0	0	0	1	0	0	0	13769	1058	37	2	11763	2	RYR2	1	237924281	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	9456678	237924281	11326340	10	1578											
SCN7A	6332	broad.mit.edu	37	chr2	167327191	167327191	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ttgaagcgttggaatgaagtCcagaggtgagtatcttataa	12	4	1	4			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr2:167327191C>A	uc002udu.1	-	6	725	c.598G>T	c.(598-600)GAC>TAC	p.D200Y	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	200	Helical; Name=S3 of repeat I; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						GGAATGAAGTCCAGAGGTGAG	0.294													A	167327191	A	A	167327191	3	1	25	1	0	0	0	0	1	0	0	0	13923	855	30	5	4530	5	SCN7A	2	167327191	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08		167327191	75872182	11	1579											
RBMS3	27303	broad.mit.edu	37	chr3	29938905	29938905	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtacagtattgcaaccaaccGcatgattccacagacatcta	6	12	1	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr3:29938905G>A	uc003cel.2	+	9	1057	c.827G>A	c.(826-828)CGC>CAC	p.R276H	RBMS3_uc003cek.2_Missense_Mutation_p.R276H|RBMS3_uc010hfq.2_Missense_Mutation_p.R289H|RBMS3_uc003cem.2_Missense_Mutation_p.R275H|RBMS3_uc010hfr.2_Missense_Mutation_p.R276H	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	276						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				GCAACCAACCGCATGATTCCA	0.433													A	29938905	A	A	29938905	3	1	25	1	0	0	0	0	1	0	0	0	13150	1087	38	1	904	1	RBMS3	3	29938905	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08		29938905	168083525	12	1580											
DNAH1	25981	broad.mit.edu	37	chr3	52422625	52422625	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggctgggccgagctggcaaGgtgcgcaccctcctcctgca	14	16	0	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr3:52422625G>A	uc011bef.1	+	58	9624	c.9363G>A	c.(9361-9363)AAG>AAA	p.K3121K	DNAH1_uc003ddv.2_5'UTR	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3121	Potential.				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAGCTGGCAAGGTGCGCACCC	0.657													A	52422625	A	A	52422625	2	1	25	1	0	0	0	0	0	0	0	1	4597	1014	35	3		3	DNAH1	3	52422625	Silent	SNP	G	TCGA-06-0154-01A-03D-1491-08	22483720	52422625	145599805	13	1581											
FETUB	26998	broad.mit.edu	37	chr3	186362610	186362610	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cccactgactcttccaatcaCcaagtgctggaggctgccac	8	16	2	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr3:186362610C>A	uc010hyq.2	+	5	756	c.495C>A	c.(493-495)CAC>CAA	p.H165Q	FETUB_uc011brz.1_Missense_Mutation_p.H17Q|FETUB_uc003fqn.2_Missense_Mutation_p.H165Q|FETUB_uc003fqo.2_Missense_Mutation_p.H60Q|FETUB_uc010hyr.2_Missense_Mutation_p.H128Q|FETUB_uc010hys.2_Missense_Mutation_p.H17Q|FETUB_uc003fqp.3_Missense_Mutation_p.H100Q	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	165	Cystatin fetuin-B-type 2.					extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		CTTCCAATCACCAAGTGCTGG	0.443													A	186362610	A	A	186362610	3	1	25	1	0	0	0	0	1	0	0	0	5821	506	18	5	509	5	FETUB	3	186362610	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	133939985	186362610	11659820	14	1582											
GABRA4	2557	broad.mit.edu	37	chr4	46973176	46973176	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaatcactgtcataatgcaCggaatataggtctgaatcat	8	7	4	2	rs147092196		TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr4:46973176C>T	uc003gxg.2	-	7	937	c.798G>A	c.(796-798)CCG>CCA	p.P266P		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	266	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCATAATGCACGGAATATAGG	0.368													T	46973176	T	T	46973176	2	4	25	1	0	0	0	0	0	0	0	1	6163	523	19	1		1	GABRA4	4	46973176	Silent	SNP	C	TCGA-06-0154-01A-03D-1491-08		46973176	144181100	15	1583											
UGT2B7	7364	broad.mit.edu	37	chr4	69962448	69962448	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgatcccaacaactcatcCgctcttaaaattgaaattta	3	10	2	2	rs151180306		TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr4:69962448C>T	uc003heg.3	+	1	256	c.210C>T	c.(208-210)TCC>TCT	p.S70S	UGT2B7_uc010ihq.2_Silent_p.S70S	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	70					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						ACAACTCATCCGCTCTTAAAA	0.373													T	69962448	T	T	69962448	2	4	25	1	0	0	0	0	0	0	0	1	16959	639	23	2		2	UGT2B7	4	69962448	Silent	SNP	C	TCGA-06-0154-01A-03D-1491-08	22989272	69962448	121191828	16	1584											
GLRA3	8001	broad.mit.edu	37	chr4	175598335	175598335	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	catccatgttgatccagaatGaaacccaggatagaataaca	7	9	0	4			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr4:175598335G>A	uc003ity.1	-	7	1324	c.821C>T	c.(820-822)TCA>TTA	p.S274L	GLRA3_uc003itz.1_Missense_Mutation_p.S274L	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	274	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GATCCAGAATGAAACCCAGGA	0.478													A	175598335	A	A	175598335	3	1	25	1	0	0	0	0	1	0	0	0	6456	1294	45	3	589	3	GLRA3	4	175598335	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	105635887	175598335	15555941	17	1585											
PRDM9	56979	broad.mit.edu	37	chr5	23526914	23526914	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acctcctcattcaccagaggAtacacacaggggagaagccc	9	14	2	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr5:23526914A>T	uc003jgo.2	+	11	1899	c.1717A>T	c.(1717-1719)ATA>TTA	p.I573L		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	573	C2H2-type 3.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TCACCAGAGGATACACACAGG	0.562										HNSCC(3;0.000094)			T	23526914	T	T	23526914	3	4	25	1	0	0	0	0	1	0	0	0	12463	333	12	5	1755	5	PRDM9	5	23526914	Missense_Mutation	SNP	A	TCGA-06-0154-01A-03D-1491-08		23526914	157388346	18	1586											
AP3S1	1176	broad.mit.edu	37	chr5	115249179	115249179	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagtgccaaacctgccctctTttaaataaaaatgtaaaaag	5	8	1	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr5:115249179T>C	uc003krl.2	+	6	690	c.574T>C	c.(574-576)TTT>CTT	p.F192L	AP3S1_uc003krk.2_Missense_Mutation_p.F170L|AP3S1_uc003krm.2_Missense_Mutation_p.F156L	NM_001284	NP_001275	Q92572	AP3S1_HUMAN	adaptor-related protein complex 3, sigma 1	192					insulin receptor signaling pathway|intracellular protein transport|vesicle-mediated transport	AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|Golgi apparatus|transport vesicle	protein binding|protein transporter activity				0		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;1.08e-07)|Epithelial(69;1.11e-06)|all cancers(49;5.2e-05)		CCTGCCCTCTTTTAAATAAAA	0.393													C	115249179	C	C	115249179	3	2	25	1	0	0	0	0	1	0	0	0	749	1841	64	4	596	4	AP3S1	5	115249179	Missense_Mutation	SNP	T	TCGA-06-0154-01A-03D-1491-08	91722265	115249179	65666081	19	1587											
PCDHA13	56136	broad.mit.edu	37	chr5	140263908	140263908	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgtcgagggcgtcggcaggCgctgtgggtccagaagcggc	19	11	0	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr5:140263908C>T	uc003lif.2	+	1	2055	c.2055C>T	c.(2053-2055)GGC>GGT	p.G685G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.G685G|PCDHA13_uc003lid.2_Silent_p.G685G	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	685	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTCGGCAGGCGCTGTGGGTC	0.632													T	140263908	T	T	140263908	2	4	25	1	0	0	0	0	0	0	0	1	11523	755	27	1		1	PCDHA13	5	140263908	Silent	SNP	C	TCGA-06-0154-01A-03D-1491-08	25014729	140263908	40651352	20	1588											
PCDHB12	56124	broad.mit.edu	37	chr5	140590224	140590224	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgccctgggcggccgagcCgggctacctggtgaccaagg	18	13	0	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr5:140590224C>T	uc003liz.2	+	1	1934	c.1745C>T	c.(1744-1746)CCG>CTG	p.P582L	PCDHB12_uc011dak.1_Missense_Mutation_p.P245L	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	582	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGGCCGAGCCGGGCTACCTG	0.692													T	140590224	T	T	140590224	3	4	25	1	0	0	0	0	1	0	0	0	11537	652	23	2	1747	2	PCDHB12	5	140590224	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	326316	140590224	40325036	21	1589											
PCDHGA5	56110	broad.mit.edu	37	chr5	140745008	140745008	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtaatcgcgctgtttagcGtacatgatggtgattctgga	12	7	1	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr5:140745008G>A	uc003lju.1	+	1	1111	c.1111G>A	c.(1111-1113)GTA>ATA	p.V371I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.V371I	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	371	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGTTTAGCGTACATGATGG	0.443													A	140745008	A	A	140745008	3	1	25	1	0	0	0	0	1	0	0	0	11557	1145	40	1	1113	1	PCDHGA5	5	140745008	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	154784	140745008	40170252	22	1590											
DOCK2	1794	broad.mit.edu	37	chr5	169503081	169503081	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggagaaggagtacggtgtccGagagatggtatgggtggttc	19	4	0	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr5:169503081G>A	uc003maf.2	+	47	4939	c.4859G>A	c.(4858-4860)CGA>CAA	p.R1620Q	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.R1112Q|DOCK2_uc003mah.2_Missense_Mutation_p.R176Q	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1620	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TACGGTGTCCGAGAGATGGTA	0.532													A	169503081	A	A	169503081	3	1	25	1	0	0	0	0	1	0	0	0	4687	1058	37	2	5045	2	DOCK2	5	169503081	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	28758073	169503081	11412179	23	1591											
AGPAT1	10554	broad.mit.edu	37	chr6	32138354	32138354	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttggcaatgggcacacagcGgcctggcagtacctccatca	11	14	1	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr6:32138354G>A	uc003oae.2	-	4	676	c.358C>T	c.(358-360)CGC>TGC	p.R120C	PPT2_uc003nzy.1_RNA|AGPAT1_uc011dpj.1_RNA|AGPAT1_uc011dpk.1_Missense_Mutation_p.R84C|AGPAT1_uc003oaf.2_Missense_Mutation_p.R120C|AGPAT1_uc003oag.2_Intron|AGPAT1_uc003oah.2_Missense_Mutation_p.R120C|AGPAT1_uc003oai.1_Missense_Mutation_p.R120C|AGPAT1_uc011dpl.1_Missense_Mutation_p.R8C	NM_006411	NP_006402	Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	120					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)	1						GGCACACAGCGGCCTGGCAGT	0.652													A	32138354	A	A	32138354	3	1	25	1	0	0	0	0	1	0	0	0	386	1116	39	2	509	2	AGPAT1	6	32138354	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08		32138354	138976713	24	1592											
SPDEF	25803	broad.mit.edu	37	chr6	34508955	34508955	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgctggggctccagtccatgGgatctgggcaagaggcatcc	15	11	1	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr6:34508955G>C	uc003ojq.1	-	3	855	c.440C>G	c.(439-441)CCC>CGC	p.P147R	SPDEF_uc011dsq.1_Missense_Mutation_p.P147R	NM_012391	NP_036523	O95238	SPDEF_HUMAN	SAM pointed domain containing ets transcription	147	PNT.				negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P147R(1)		skin(3)|ovary(1)|central_nervous_system(1)	5						CCAGTCCATGGGATCTGGGCA	0.647													C	34508955	C	C	34508955	3	2	25	1	0	0	0	0	1	0	0	0	15025	1232	43	5	583	5	SPDEF	6	34508955	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	2370601	34508955	136606112	25	1593											
KHDRBS2	202559	broad.mit.edu	37	chr6	62604709	62604709	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacacctcgtccaggtggtGggggaggaggaatggcaccc	17	10	0	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr6:62604709G>A	uc003peg.2	-	6	888	c.641C>T	c.(640-642)CCA>CTA	p.P214L		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	214	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TCCAGGTGGTGGGGGAGGAGG	0.557													A	62604709	A	A	62604709	3	1	25	1	0	0	0	0	1	0	0	0	8147	1348	47	3	424	3	KHDRBS2	6	62604709	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	28095754	62604709	108510358	26	1594											
ANKRD6	22881	broad.mit.edu	37	chr6	90337365	90337365	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaggacggagtgcctgaacCgcctgcaacagcactcagac	12	13	1	3			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr6:90337365C>T	uc003pni.3	+	14	1776	c.1435C>T	c.(1435-1437)CGC>TGC	p.R479C	ANKRD6_uc003pne.3_Missense_Mutation_p.R479C|ANKRD6_uc003pnf.3_Missense_Mutation_p.R444C|ANKRD6_uc011dzy.1_Missense_Mutation_p.R479C|ANKRD6_uc010kcd.2_Missense_Mutation_p.R420C|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_Missense_Mutation_p.R75C|LYRM2_uc010kcf.1_Intron|ANKRD6_uc003pnj.3_Missense_Mutation_p.R75C	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	479							protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		GTGCCTGAACCGCCTGCAACA	0.512													T	90337365	T	T	90337365	3	4	25	1	0	0	0	0	1	0	0	0	685	652	23	2	1485	2	ANKRD6	6	90337365	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	27732656	90337365	80777702	27	1595											
KIAA1244	57221	broad.mit.edu	37	chr6	138531166	138531166	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcaacgaggacctgcaggtGgaagtgatgaaggttggttt	15	6	1	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr6:138531166G>T	uc003qhu.2	+	4	339	c.339G>T	c.(337-339)GTG>GTT	p.V113V		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	113					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ACCTGCAGGTGGAAGTGATGA	0.502													T	138531166	T	T	138531166	2	4	25	1	0	0	0	0	0	0	0	1	8217	1335	47	5		5	KIAA1244	6	138531166	Silent	SNP	G	TCGA-06-0154-01A-03D-1491-08	48193801	138531166	32583901	28	1596											
KIAA1244	57221	broad.mit.edu	37	chr6	138657552	138657552	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agctgacctgtcacgtgaccGacatcagagttcgccaggct	11	13	2	3			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr6:138657552G>A	uc003qhu.2	+	34	6463	c.6463G>A	c.(6463-6465)GAC>AAC	p.D2155N		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	2155					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TCACGTGACCGACATCAGAGT	0.562													A	138657552	A	A	138657552	3	1	25	1	0	0	0	0	1	0	0	0	8217	1058	37	2	6597	2	KIAA1244	6	138657552	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	126386	138657552	32457515	29	1597											
PLG	5340	broad.mit.edu	37	chr6	161139731	161139731	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacttctttttcagaaatttGgatgaaaactactgccgcaa	6	9	2	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr6:161139731G>A	uc003qtm.3	+	9	1020	c.957G>A	c.(955-957)TTG>TTA	p.L319L		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	319	Kringle 3.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TCAGAAATTTGGATGAAAACT	0.453													A	161139731	A	A	161139731	2	1	25	1	0	0	0	0	0	0	0	1	12086	1339	47	3		3	PLG	6	161139731	Silent	SNP	G	TCGA-06-0154-01A-03D-1491-08	22482179	161139731	9975336	30	1598											
GHRHR	2692	broad.mit.edu	37	chr7	31016046	31016046	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatttgtctttcctgcaggcGtctctccaagtcgacacttt	8	12	2	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr7:31016046G>A	uc003tbx.2	+	11	1025	c.977G>A	c.(976-978)CGT>CAT	p.R326H	GHRHR_uc003tby.2_Missense_Mutation_p.R262H|GHRHR_uc003tbz.2_Silent_p.A92A	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	326	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	TCCTGCAGGCGTCTCTCCAAG	0.423													A	31016046	A	A	31016046	3	1	25	1	0	0	0	0	1	0	0	0	6373	1145	40	1	1059	1	GHRHR	7	31016046	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08		31016046	128122617	31	1599											
EGFR	1956	broad.mit.edu	37	chr7	55220274	55220274	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcccagcagtgctccgggCgctgccgtggcaagtccccc	14	17	0	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr7:55220274C>T	uc003tqk.2	+	6	910	c.664C>T	c.(664-666)CGC>TGC	p.R222C	EGFR_uc003tqh.2_Missense_Mutation_p.R222C|EGFR_uc003tqi.2_Missense_Mutation_p.R222C|EGFR_uc003tqj.2_Missense_Mutation_p.R222C|EGFR_uc010kzg.1_Missense_Mutation_p.R177C|EGFR_uc011kco.1_Missense_Mutation_p.R169C|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	222	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.R222C(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGCTCCGGGCGCTGCCGTGG	0.597		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55220274	T	T	55220274	3	4	25	1	0	0	0	0	1	0	0	0	4967	768	27	1	686	1	EGFR	7	55220274	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	24204228	55220274	103918389	32	1600											
WBSCR28	135886	broad.mit.edu	37	chr7	73280082	73280082	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagcacacgacccagctggCcgaggcccaggaggttgaac	14	13	0	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr7:73280082C>T	uc003tzk.2	+	3	713	c.677C>T	c.(676-678)GCC>GTC	p.A226V	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_Missense_Mutation_p.A125V	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	226						integral to membrane				breast(1)	1		Lung NSC(55;0.159)				ACCCAGCTGGCCGAGGCCCAG	0.627													T	73280082	T	T	73280082	3	4	25	1	0	0	0	0	1	0	0	0	17264	739	26	3	687	3	WBSCR28	7	73280082	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	18059808	73280082	85858581	33	1601											
ASNS	440	broad.mit.edu	37	chr7	97484694	97484694	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atatatgtaaccctgcgtaaGttcatctgatccttctccag	6	11	3	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr7:97484694G>A	uc003uot.3	-	9	1614	c.1108C>T	c.(1108-1110)CTT>TTT	p.L370F	ASNS_uc011kin.1_Missense_Mutation_p.L287F|ASNS_uc003uou.3_Missense_Mutation_p.L370F|ASNS_uc003uov.3_Missense_Mutation_p.L370F|ASNS_uc011kio.1_Missense_Mutation_p.L349F|ASNS_uc003uow.3_Missense_Mutation_p.L349F|ASNS_uc003uox.3_Missense_Mutation_p.L287F	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	370	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCCTGCGTAAGTTCATCTGAT	0.338													A	97484694	A	A	97484694	3	1	25	1	0	0	0	0	1	0	0	0	1048	1029	36	3	597	3	ASNS	7	97484694	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	24204612	97484694	61653969	34	1602											
CNTNAP2	26047	broad.mit.edu	37	chr7	146997332	146997332	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agatgaagcatcagcagttcGaactaatagtccccttcaag	8	10	2	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr7:146997332G>A	uc003weu.1	+	9	1964	c.1448G>A	c.(1447-1449)CGA>CAA	p.R483Q		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	483	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCAGCAGTTCGAACTAATAGT	0.423										HNSCC(39;0.1)			A	146997332	A	A	146997332	3	1	25	1	0	0	0	0	1	0	0	0	3647	1058	37	2	1482	2	CNTNAP2	7	146997332	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	49512638	146997332	12141331	35	1603											
PTPRD	5789	broad.mit.edu	37	chr9	8633320	8633320	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcacttgagcacttaccccGcaaaactgtgagtctggtgg	10	11	2	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr9:8633320G>A	uc003zkk.2	-	13	1060	c.349C>T	c.(349-351)CGG>TGG	p.R117W	PTPRD_uc003zkp.2_Missense_Mutation_p.R117W|PTPRD_uc003zkq.2_Missense_Mutation_p.R117W|PTPRD_uc003zkr.2_Missense_Mutation_p.R117W|PTPRD_uc003zks.2_Missense_Mutation_p.R117W|PTPRD_uc003zkl.2_Missense_Mutation_p.R117W|PTPRD_uc003zkm.2_Missense_Mutation_p.R117W|PTPRD_uc003zkn.2_Missense_Mutation_p.R117W|PTPRD_uc003zko.2_Missense_Mutation_p.R117W|PTPRD_uc003zkt.1_Missense_Mutation_p.R117W	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	117	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CACTTACCCCGCAAAACTGTG	0.418										TSP Lung(15;0.13)			A	8633320	A	A	8633320	3	1	25	1	0	0	0	0	1	0	0	0	12799	1086	38	1	5589	1	PTPRD	9	8633320	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08		8633320	132580111	36	1604											
KIAA1797	54914	broad.mit.edu	37	chr9	20976500	20976500	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agaaagctaccaatatcctcCtgtgaactgggctgcacttc	8	12	0	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr9:20976500C>A	uc003zog.1	+	38	4577	c.4214C>A	c.(4213-4215)CCT>CAT	p.P1405H	KIAA1797_uc003zoh.1_Missense_Mutation_p.P841H	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1405						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		CAATATCCTCCTGTGAACTGG	0.393													A	20976500	A	A	20976500	3	1	25	1	0	0	0	0	1	0	0	0	8258	681	24	5	4352	5	KIAA1797	9	20976500	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	12343180	20976500	120236931	37	1605											
NXNL2	158046	broad.mit.edu	37	chr9	91150637	91150637	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctggcgctgcccttccaCgacccctaccggcagtgagt	12	16	0	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr9:91150637C>T	uc011ltj.1	+	1	622	c.288C>T	c.(286-288)CAC>CAT	p.H96H	NXNL2_uc004aqa.2_Silent_p.H96H	NM_001161625	NP_001155097	Q5VZ03	NXNL2_HUMAN	nucleoredoxin-like 2 isoform 1	96	Thioredoxin.										0						TGCCCTTCCACGACCCCTACC	0.602													T	91150637	T	T	91150637	2	4	25	1	0	0	0	0	0	0	0	1	10789	535	19	1		1	NXNL2	9	91150637	Silent	SNP	C	TCGA-06-0154-01A-03D-1491-08	70174137	91150637	50062794	38	1606											
CERCAM	51148	broad.mit.edu	37	chr9	131185156	131185156	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgtccccaggtgtgccacGgaccacaatgtggacaacac	10	16	0	0	rs147490658	by1000genomes	TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr9:131185156G>A	uc004buz.3	+	2	605	c.207G>A	c.(205-207)ACG>ACA	p.T69T	CERCAM_uc004buy.1_5'UTR|CERCAM_uc010mxz.2_5'UTR|CERCAM_uc010mya.1_5'Flank	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	69					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						GGTGTGCCACGGACCACAATG	0.602													A	131185156	A	A	131185156	2	1	25	1	0	0	0	0	0	0	0	1	3266	1103	39	2		2	CERCAM	9	131185156	Silent	SNP	G	TCGA-06-0154-01A-03D-1491-08	40034519	131185156	10028275	39	1607											
ARHGAP21	57584	broad.mit.edu	37	chr10	24889768	24889768	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gctcttcctcagacggagtcGtctgctctcttttatctttg	8	12	5	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr10:24889768G>C	uc001isb.2	-	14	3426	c.2939C>G	c.(2938-2940)ACG>AGG	p.T980R	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Missense_Mutation_p.T980R|ARHGAP21_uc010qdc.1_Missense_Mutation_p.T815R	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	979	Interaction with ARF1 and ARF6.|PH.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						AGACGGAGTCGTCTGCTCTCT	0.453													C	24889768	C	C	24889768	3	2	25	1	0	0	0	0	1	0	0	0	871	1145	40	5	2989	5	ARHGAP21	10	24889768	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08		24889768	110644979	40	1608											
APBB1IP	54518	broad.mit.edu	37	chr10	26825105	26825105	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaggcgctattttcttttaCgggcttctggaatttattat	8	6	2	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr10:26825105C>T	uc001iss.2	+	10	1324	c.1003C>T	c.(1003-1005)CGG>TGG	p.R335W	APBB1IP_uc009xks.1_Missense_Mutation_p.R335W	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	335	PH.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium		p.R335W(1)		lung(4)|skin(2)|central_nervous_system(1)	7						TTTTCTTTTACGGGCTTCTGG	0.338													T	26825105	T	T	26825105	3	4	25	1	0	0	0	0	1	0	0	0	760	527	19	1	1033	1	APBB1IP	10	26825105	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	1935337	26825105	108709642	41	1609											
ANK3	288	broad.mit.edu	37	chr10	61829891	61829891	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagttggcgttctggctggcGttgtatcaggggttgttgct	16	7	2	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr10:61829891G>A	uc001jky.2	-	37	10940	c.10748C>T	c.(10747-10749)ACG>ATG	p.T3583M	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3583					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding	p.T3583M(1)		skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TCTGGCTGGCGTTGTATCAGG	0.488													A	61829891	A	A	61829891	3	1	25	1	0	0	0	0	1	0	0	0	622	1145	40	1	2726	1	ANK3	10	61829891	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	35004786	61829891	73704856	42	1610											
OR5M3	219482	broad.mit.edu	37	chr11	56237372	56237372	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatatgtgaagttaatgccgGcaagtatgatcattgtatat	9	4	1	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr11:56237372G>A	uc010rjk.1	-	1	602	c.602C>T	c.(601-603)GCC>GTC	p.A201V		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTTAATGCCGGCAAGTATGAT	0.413													A	56237372	A	A	56237372	3	1	25	1	0	0	0	0	1	0	0	0	11175	1203	42	3	323	3	OR5M3	11	56237372	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08		56237372	78769144	43	1611											
OR9G4	283189	broad.mit.edu	37	chr11	56510792	56510792	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tatggcattcaaaaatcctcCtatgtaggagccagcaacaa	7	10	1	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr11:56510792C>A	uc010rjo.1	-	1	496	c.496G>T	c.(496-498)GGA>TGA	p.G166*		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	166	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						AAAAATCCTCCTATGTAGGAG	0.453													A	56510792	A	A	56510792	4	1	25	1	0	0	0	0	0	1	0	0	11251	690	24	5	490	5	OR9G4	11	56510792	Nonsense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	273420	56510792	78495724	44	1612											
HNRNPUL2	221092	broad.mit.edu	37	chr11	62490074	62490074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactttcaggagcacttacaGcaaagcagccaataacatca	6	11	2	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr11:62490074G>A	uc001nuw.2	-	6	1287	c.1094C>T	c.(1093-1095)GCT>GTT	p.A365V	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	365	B30.2/SPRY.				cell killing	nucleus	ATP binding|nucleic acid binding				0						AGCACTTACAGCAAAGCAGCC	0.458													A	62490074	A	A	62490074	3	1	25	1	0	0	0	0	1	0	0	0	7275	985	34	3	1185	3	HNRNPUL2	11	62490074	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	5979282	62490074	72516442	45	1613											
KLC2	64837	broad.mit.edu	37	chr11	66033175	66033175	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggggccctataccggcgcCagggcaagctggaagccgcg	17	13	0	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr11:66033175C>T	uc010rov.1	+	12	1627	c.1384C>T	c.(1384-1386)CAG>TAG	p.Q462*	KLC2_uc010row.1_Nonsense_Mutation_p.Q462*|KLC2_uc009yra.2_Intron|KLC2_uc001ohb.2_Nonsense_Mutation_p.Q462*|KLC2_uc010rox.1_Nonsense_Mutation_p.Q385*|KLC2_uc001ohc.2_Nonsense_Mutation_p.Q462*|KLC2_uc001ohd.2_Nonsense_Mutation_p.Q385*|KLC2_uc001ohe.1_Nonsense_Mutation_p.Q323*|RAB1B_uc001ohf.2_5'Flank	NM_001134775	NP_001128247	Q9H0B6	KLC2_HUMAN	kinesin light chain 2 isoform 1	462	TPR 6.				blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0						ATACCGGCGCCAGGGCAAGCT	0.647													T	66033175	T	T	66033175	4	4	25	1	0	0	0	0	0	1	0	0	8334	595	21	3	1426	3	KLC2	11	66033175	Nonsense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	3543101	66033175	68973341	46	1614											
CHORDC1	26973	broad.mit.edu	37	chr11	89951306	89951306	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatatagttcctaccttTaatgcatcgtgaaagaccgg	8	8	0	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr11:89951306T>C	uc001pdg.2	-	2	521	c.111A>G	c.(109-111)TTA>TTG	p.L37L	CHORDC1_uc009yvz.2_Silent_p.L37L	NM_012124	NP_036256	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain-containing	37	Interaction with PPP5C (By similarity).|CHORD 1.				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				TTCCTACCTTTAATGCATCGT	0.313													C	89951306	C	C	89951306	2	2	25	1	0	0	0	0	0	0	0	1	3365	1751	61	4		4	CHORDC1	11	89951306	Silent	SNP	T	TCGA-06-0154-01A-03D-1491-08	23918131	89951306	45055210	47	1615											
KLRK1	22914	broad.mit.edu	37	chr12	10525755	10525755	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgtacgtatttggagttgaAcagttttctatatagccttt	8	5	1	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr12:10525755A>G	uc009zhj.2	-	8	773	c.609T>C	c.(607-609)TGT>TGC	p.C203C	uc001qya.1_Intron|KLRK1_uc001qyb.2_RNA|KLRK1_uc001qyc.2_Silent_p.C203C|KLRK1_uc009zhk.2_Silent_p.C203C|KLRK1_uc001qyd.2_Silent_p.C203C	NM_007360	NP_031386	P26718	NKG2D_HUMAN	NKG2-D type II integral membrane protein	203	Extracellular (Potential).|C-type lectin.				natural killer cell activation|T cell costimulation	integral to plasma membrane	sugar binding				0						TTGGAGTTGAACAGTTTTCTA	0.279													G	10525755	G	G	10525755	2	3	25	1	0	0	0	0	0	0	0	1	8423	41	2	4		4	KLRK1	12	10525755	Silent	SNP	A	TCGA-06-0154-01A-03D-1491-08		10525755	123326140	48	1616											
PIK3C2G	5288	broad.mit.edu	37	chr12	18552608	18552608	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttcagactctctgaagaaaaGaaaagatatttatggtttta	7	4	2	5			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr12:18552608G>C	uc001rdt.2	+	15	2135	c.2019G>C	c.(2017-2019)AAG>AAC	p.K673N	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.K714N|PIK3C2G_uc010sic.1_Missense_Mutation_p.K492N	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	673					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CTGAAGAAAAGAAAAGATATT	0.378													C	18552608	C	C	18552608	3	2	25	1	0	0	0	0	1	0	0	0	11911	933	33	5	2073	5	PIK3C2G	12	18552608	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	8026853	18552608	115299287	49	1617											
OR6C74	254783	broad.mit.edu	37	chr12	55641790	55641790	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaaagcattttctacatgttCttcccacatggtggtcgtgt	8	9	2	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr12:55641790C>T	uc010spg.1	+	1	719	c.719C>T	c.(718-720)TCT>TTT	p.S240F		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TCTACATGTTCTTCCCACATG	0.373													T	55641790	T	T	55641790	3	4	25	1	0	0	0	0	1	0	0	0	11198	913	32	3	721	3	OR6C74	12	55641790	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	37089182	55641790	78210105	50	1618											
LRP1	4035	broad.mit.edu	37	chr12	57569290	57569290	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcagccacaactgctcagtgGcacctggcgaaggcattgtg	13	12	1	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr12:57569290G>C	uc001snd.2	+	23	4061	c.3595G>C	c.(3595-3597)GCA>CCA	p.A1199P		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1199	EGF-like 5.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTGCTCAGTGGCACCTGGCGA	0.602											OREG0021937	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	57569290	C	C	57569290	3	2	25	1	0	0	0	0	1	0	0	0	8951	1203	42	5	3685	5	LRP1	12	57569290	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	1927500	57569290	76282605	51	1619											
GALNT9	50614	broad.mit.edu	37	chr12	132682414	132682414	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgggcatgcggcccgtgcCgtcatccaccagacacttgg	14	14	1	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr12:132682414C>T	uc001ukc.3	-	10	1704	c.1588G>A	c.(1588-1590)GGC>AGC	p.G530S	GALNT9_uc009zyr.2_Missense_Mutation_p.G304S|GALNT9_uc001ukb.2_Missense_Mutation_p.G387S|GALNT9_uc001uka.2_Missense_Mutation_p.G164S	NM_001122636	NP_001116108	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	530	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		CGGCCCGTGCCGTCATCCACC	0.657													T	132682414	T	T	132682414	3	4	25	1	0	0	0	0	1	0	0	0	6220	652	23	2	231	2	GALNT9	12	132682414	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	75113124	132682414	1169481	52	1620											
SYNE2	23224	broad.mit.edu	37	chr14	64457171	64457171	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtttgatgagcttatggcaAgaagtgaagatatgttacaa	11	3	0	5			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr14:64457171A>G	uc001xgm.2	+	20	2586	c.2356A>G	c.(2356-2358)AGA>GGA	p.R786G	SYNE2_uc001xgl.2_Missense_Mutation_p.R786G	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	786	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GCTTATGGCAAGAAGTGAAGA	0.343													G	64457171	G	G	64457171	3	3	25	1	0	0	0	0	1	0	0	0	15443	64	3	4	2430	4	SYNE2	14	64457171	Missense_Mutation	SNP	A	TCGA-06-0154-01A-03D-1491-08		64457171	42892369	53	1621											
GABRA5	2558	broad.mit.edu	37	chr15	27182399	27182399	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accaagtcggtggtggtggcGgaagatggctccagactgaa	16	8	0	3			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr15:27182399G>A	uc001zbd.1	+	9	987	c.648G>A	c.(646-648)GCG>GCA	p.A216A	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	216	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGGTGGTGGCGGAAGATGGCT	0.577													A	27182399	A	A	27182399	2	1	25	1	0	0	0	0	0	0	0	1	6164	1103	39	2		2	GABRA5	15	27182399	Silent	SNP	G	TCGA-06-0154-01A-03D-1491-08		27182399	75348993	54	1622											
BAHD1	22893	broad.mit.edu	37	chr15	40751044	40751044	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tccctcaatgctgaagctctCaataacctgctgctggagcg	9	13	2	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr15:40751044C>T	uc001zlu.2	+	2	452	c.381C>T	c.(379-381)CTC>CTT	p.L127L	BAHD1_uc001zlt.2_Silent_p.L127L|BAHD1_uc010bbp.1_Silent_p.L127L|BAHD1_uc001zlv.2_Silent_p.L127L	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	127					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CTGAAGCTCTCAATAACCTGC	0.682													T	40751044	T	T	40751044	2	4	25	1	0	0	0	0	0	0	0	1	1297	813	29	3		3	BAHD1	15	40751044	Silent	SNP	C	TCGA-06-0154-01A-03D-1491-08	13568645	40751044	61780348	55	1623											
CREBBP	1387	broad.mit.edu	37	chr16	3807844	3807844	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatatccaagggactgcatgAcagggtcaatttcctgctca	9	10	2	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr16:3807844A>G	uc002cvv.2	-	18	3779	c.3575T>C	c.(3574-3576)GTC>GCC	p.V1192A	CREBBP_uc002cvw.2_Missense_Mutation_p.V1154A	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1192					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GGACTGCATGACAGGGTCAAT	0.443			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				G	3807844	G	G	3807844	3	3	25	1	0	0	0	0	1	0	0	0	3861	275	10	4	3809	4	CREBBP	16	3807844	Missense_Mutation	SNP	A	TCGA-06-0154-01A-03D-1491-08		3807844	86546909	56	1624											
XYLT1	64131	broad.mit.edu	37	chr16	17228564	17228564	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaccacggcttcaaacttgCgggcaaagaaggtaggccgg	13	11	2	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr16:17228564C>T	uc002dfa.2	-	9	1878	c.1793G>A	c.(1792-1794)CGC>CAC	p.R598H		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	598	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						TTCAAACTTGCGGGCAAAGAA	0.552													T	17228564	T	T	17228564	3	4	25	1	0	0	0	0	1	0	0	0	17460	768	27	1	1102	1	XYLT1	16	17228564	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	13420720	17228564	73126189	57	1625											
RLTPR	146206	broad.mit.edu	37	chr16	67683162	67683162	+	Frame_Shift_Del	DEL	C	-	-													ggcccctgcccacagggagaCcctggacgacgtcctgcacc							TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr16:67683162delC	uc002etn.2	+	19	1814	c.1694delC	c.(1693-1695)ACCfs	p.T565fs	RLTPR_uc010cel.1_Frame_Shift_Del_p.T558fs|RLTPR_uc010vjr.1_Frame_Shift_Del_p.T529fs	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	565	LRR 12.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CACAGGGAGACCCTGGACGAC	0.637													-	67683162	-	-	67683162	7	5	25	1	0	1	0	1	0	0	0	0	13394	507	18	0	1768	0	RLTPR	16	67683162	Frame_Shift_Del	DEL	C	TCGA-06-0154-01A-03D-1491-08	50454598	67683162	22671591	58	1626											
ZNF23	7571	broad.mit.edu	37	chr16	71482423	71482423	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attccttacattgatagggcTtttctccagtatggattcgg	9	8	1	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr16:71482423T>C	uc002faf.2	-	6	2319	c.1505A>G	c.(1504-1506)AAG>AGG	p.K502R	ZNF23_uc002fad.2_Missense_Mutation_p.K444R|ZNF23_uc002fae.2_Missense_Mutation_p.K444R|ZNF23_uc010vmf.1_Missense_Mutation_p.K444R|ZNF23_uc002fag.2_Missense_Mutation_p.K444R|ZNF23_uc002fah.2_Missense_Mutation_p.K502R|ZNF23_uc002fai.2_Missense_Mutation_p.K541R	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		TTGATAGGGCTTTTCTCCAGT	0.403													C	71482423	C	C	71482423	3	2	25	1	0	0	0	0	1	0	0	0	17780	1609	56	4	430	4	ZNF23	16	71482423	Missense_Mutation	SNP	T	TCGA-06-0154-01A-03D-1491-08	3799261	71482423	18872330	59	1627											
MYH2	4620	broad.mit.edu	37	chr17	10428788	10428788	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gctgtaagtttttgttctctCgcttcagggtttctagctga	10	8	3	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr17:10428788C>T	uc010coi.2	-	32	4645	c.4517G>A	c.(4516-4518)CGA>CAA	p.R1506Q	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1506Q|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1506	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R1506*(1)		ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TTTGTTCTCTCGCTTCAGGGT	0.428													T	10428788	T	T	10428788	3	4	25	1	0	0	0	0	1	0	0	0	10035	884	31	2	1344	2	MYH2	17	10428788	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08		10428788	70766422	60	1628											
MYH2	4620	broad.mit.edu	37	chr17	10442604	10442604	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtccagctgctggttgatgCgggcaaccatccacaggaac	12	12	0	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr17:10442604C>T	uc010coi.2	-	14	1462	c.1334G>A	c.(1333-1335)CGC>CAC	p.R445H	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R445H|MYH2_uc010coj.2_Missense_Mutation_p.R445H	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	445	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.R445H(1)		ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTGGTTGATGCGGGCAACCAT	0.473													T	10442604	T	T	10442604	3	4	25	1	0	0	0	0	1	0	0	0	10035	768	27	1	4599	1	MYH2	17	10442604	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	13816	10442604	70752606	61	1629											
GAS2L2	246176	broad.mit.edu	37	chr17	34074267	34074267	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtggggccgggggcttcaGgaagctgcctggcttgtgtg	20	8	1	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr17:34074267G>A	uc002hjv.1	-	5	881	c.853C>T	c.(853-855)CTG>TTG	p.L285L		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	285					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGGGGCTTCAGGAAGCTGCCT	0.597													A	34074267	A	A	34074267	2	1	25	1	0	0	0	0	0	0	0	1	6247	991	35	3		3	GAS2L2	17	34074267	Silent	SNP	G	TCGA-06-0154-01A-03D-1491-08	23631663	34074267	47120943	62	1630											
KRT33B	3884	broad.mit.edu	37	chr17	39522870	39522870	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgccgcagggactgctccGtctggtacctgcacacacag	12	15	1	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr17:39522870G>A	uc002hwl.2	-	3	485	c.440C>T	c.(439-441)ACG>ATG	p.T147M		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	147	Rod.|Coil 1B.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				GGACTGCTCCGTCTGGTACCT	0.517													A	39522870	A	A	39522870	3	1	25	1	0	0	0	0	1	0	0	0	8470	1145	40	1	794	1	KRT33B	17	39522870	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	5448603	39522870	41672340	63	1631											
KRT34	3885	broad.mit.edu	37	chr17	39535941	39535941	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggggcagtgtccacctccaCgttgaggcggtctccaagct	14	13	1	1	rs140296098	byFrequency	TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr17:39535941C>T	uc002hwm.2	-	4	769	c.757G>A	c.(757-759)GTG>ATG	p.V253M		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	253	Rod.|Linker 12.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TCCACCTCCACGTTGAGGCGG	0.552													T	39535941	T	T	39535941	3	4	25	1	0	0	0	0	1	0	0	0	8471	536	19	1	569	1	KRT34	17	39535941	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	13071	39535941	41659269	64	1632											
OTOP3	347741	broad.mit.edu	37	chr17	72937902	72937902	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcggggcccctctgggtgcGgggtgagtgtcaggttgctg	20	10	2	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr17:72937902G>A	uc010wrr.1	+	2	488	c.488G>A	c.(487-489)CGG>CAG	p.R163Q	OTOP3_uc010wrq.1_Missense_Mutation_p.R145Q	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	163	Helical; (Potential).					integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					CTCTGGGTGCGGGGTGAGTGT	0.687													A	72937902	A	A	72937902	3	1	25	1	0	0	0	0	1	0	0	0	11307	1116	39	2	494	2	OTOP3	17	72937902	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	33401961	72937902	8257308	65	1633											
ZFR2	23217	broad.mit.edu	37	chr19	3825291	3825291	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcctgctcgaggcacacaCgctggggccagtgggggacg	18	12	0	0			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr19:3825291C>T	uc002lyw.2	-	7	1162	c.1150G>A	c.(1150-1152)GTG>ATG	p.V384M	ZFR2_uc010xhx.1_Intron	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	384						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		GAGGCACACACGCTGGGGCCA	0.672													T	3825291	T	T	3825291	3	4	25	1	0	0	0	0	1	0	0	0	17657	536	19	1	1721	1	ZFR2	19	3825291	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08		3825291	55303692	66	1634											
OR7D2	162998	broad.mit.edu	37	chr19	9297245	9297245	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggggtccacttcacttctgCggtgactcactcttcccaga	9	14	4	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr19:9297245C>T	uc002mkz.1	+	1	976	c.788C>T	c.(787-789)GCG>GTG	p.A263V		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	263	Extracellular (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						TTCACTTCTGCGGTGACTCAC	0.507													T	9297245	T	T	9297245	3	4	25	1	0	0	0	0	1	0	0	0	11219	768	27	1	790	1	OR7D2	19	9297245	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	5471954	9297245	49831738	67	1635											
TRMT1	55621	broad.mit.edu	37	chr19	13218442	13218442	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagtctctgatagtcgctccCgtttcaccggacattccttc	7	14	2	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr19:13218442C>T	uc002mwj.2	-	13	1779	c.1529G>A	c.(1528-1530)CGG>CAG	p.R510Q	TRMT1_uc010xmy.1_Missense_Mutation_p.R114Q|TRMT1_uc002mwk.2_Missense_Mutation_p.R481Q|TRMT1_uc002mwl.3_Missense_Mutation_p.R510Q|TRMT1_uc010xmz.1_Missense_Mutation_p.R296Q	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	510							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		TAGTCGCTCCCGTTTCACCGG	0.617													T	13218442	T	T	13218442	3	4	25	1	0	0	0	0	1	0	0	0	16558	652	23	2	466	2	TRMT1	19	13218442	Missense_Mutation	SNP	C	TCGA-06-0154-01A-03D-1491-08	3921197	13218442	45910541	68	1636											
NLRP2	55655	broad.mit.edu	37	chr19	55494686	55494686	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgtacagaagctgctttcCggagtagaaagactcaggaa	12	8	1	3			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr19:55494686C>T	uc002qij.2	+	6	1706	c.1620C>T	c.(1618-1620)TCC>TCT	p.S540S	NLRP2_uc010yfp.1_Silent_p.S517S|NLRP2_uc010esn.2_Silent_p.S516S|NLRP2_uc010eso.2_Silent_p.S537S|NLRP2_uc010esp.2_Silent_p.S518S	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	540					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AGCTGCTTTCCGGAGTAGAAA	0.552													T	55494686	T	T	55494686	2	4	25	1	0	0	0	0	0	0	0	1	10477	639	23	2		2	NLRP2	19	55494686	Silent	SNP	C	TCGA-06-0154-01A-03D-1491-08	42276244	55494686	3634297	69	1637											
PDYN	5173	broad.mit.edu	37	chr20	1961100	1961100	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcttgggacgaatgcgccGcaagaagcccccatagcgtt	13	12	0	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr20:1961100G>A	uc010gaj.2	-	3	876	c.634C>T	c.(634-636)CGG>TGG	p.R212W	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.R212W|PDYN_uc010zpt.1_Missense_Mutation_p.R57W	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	212			R -> W (in SCA23; the mutant PDYN protein is produced, but processing to opioid peptides is dramatically affected, with increased levels of dynorphin A compared to dynorphin B; mutant dynorphin A is neurotoxic to cultured striatal neurons, suggesting a dominant-negative effect).		cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						CGAATGCGCCGCAAGAAGCCC	0.587													A	1961100	A	A	1961100	3	1	25	1	0	0	0	0	1	0	0	0	11699	1086	38	1	134	1	PDYN	20	1961100	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08		1961100	61064420	70	1638											
SPAG4	6676	broad.mit.edu	37	chr20	34206631	34206631	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtgtccactgttcgggcaGccaacagcgaggtgagcccc	14	13	0	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr20:34206631G>A	uc002xdb.1	+	7	823	c.706G>A	c.(706-708)GCC>ACC	p.A236T	SPAG4_uc010zvi.1_Missense_Mutation_p.A159T	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	236	Potential.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			TGTTCGGGCAGCCAACAGCGA	0.642													A	34206631	A	A	34206631	3	1	25	1	0	0	0	0	1	0	0	0	14980	971	34	3	732	3	SPAG4	20	34206631	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	32245531	34206631	28818889	71	1639											
PCIF1	63935	broad.mit.edu	37	chr20	44571848	44571848	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaccagtcgtgtcaccttcCatgtttcgtgaaatcatgaa	8	10	2	2	rs35751664		TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr20:44571848C>T	uc002xqs.2	+	8	1100	c.786C>T	c.(784-786)TCC>TCT	p.S262S	PCIF1_uc002xqt.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	262						nucleus				skin(1)	1						TGTCACCTTCCATGTTTCGTG	0.527													T	44571848	T	T	44571848	2	4	25	1	0	0	0	0	0	0	0	1	11580	581	21	3		3	PCIF1	20	44571848	Silent	SNP	C	TCGA-06-0154-01A-03D-1491-08	10365217	44571848	18453672	72	1640											
RIPK4	54101	broad.mit.edu	37	chr21	43161994	43161994	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgagcagcagccacttggcGcactcctcttgcccggcctc	10	17	1	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr21:43161994G>A	uc002yzn.1	-	8	1407	c.1359C>T	c.(1357-1359)TGC>TGT	p.C453C		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	453						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity	p.C453C(1)		ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GCCACTTGGCGCACTCCTCTT	0.657													A	43161994	A	A	43161994	2	1	25	1	0	0	0	0	0	0	0	1	13383	1079	38	1		1	RIPK4	21	43161994	Silent	SNP	G	TCGA-06-0154-01A-03D-1491-08		43161994	4967901	73	1641											
SLC5A4	6527	broad.mit.edu	37	chr22	32650199	32650199	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcggttggtcttcagcatcGcctgagcagaagggaagaca	13	10	2	3			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr22:32650199G>A	uc003ami.2	-	2	139	c.137C>T	c.(136-138)GCG>GTG	p.A46V		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	46	Helical; (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CTTCAGCATCGCCTGAGCAGA	0.572													A	32650199	A	A	32650199	3	1	25	1	0	0	0	0	1	0	0	0	14667	1101	38	1	1898	1	SLC5A4	22	32650199	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08		32650199	18654367	74	1642											
ISX	91464	broad.mit.edu	37	chr22	35480407	35480407	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatcagcgagccaagtggcGgaagcaggagaagattggca	16	7	1	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr22:35480407G>A	uc003anj.2	+	3	1364	c.413G>A	c.(412-414)CGG>CAG	p.R138Q	ISX_uc011amg.1_Missense_Mutation_p.R126Q	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	138	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						GCCAAGTGGCGGAAGCAGGAG	0.537													A	35480407	A	A	35480407	3	1	25	1	0	0	0	0	1	0	0	0	7865	1116	39	2	423	2	ISX	22	35480407	Missense_Mutation	SNP	G	TCGA-06-0154-01A-03D-1491-08	2830208	35480407	15824159	75	1643											
SGSM3	27352	broad.mit.edu	37	chr22	40803235	40803235	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctggaggcactcaaggccaAgaacatcaagcagacggaac	11	12	2	2			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chr22:40803235A>G	uc003ayu.1	+	12	1480	c.1271A>G	c.(1270-1272)AAG>AGG	p.K424R	SGSM3_uc011aos.1_Missense_Mutation_p.K357R|SGSM3_uc011aot.1_Missense_Mutation_p.K361R|SGSM3_uc010gyd.1_Missense_Mutation_p.K467R	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	424	Potential.				cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						CTCAAGGCCAAGAACATCAAG	0.627													G	40803235	G	G	40803235	3	3	25	1	0	0	0	0	1	0	0	0	14224	72	3	4	1313	4	SGSM3	22	40803235	Missense_Mutation	SNP	A	TCGA-06-0154-01A-03D-1491-08	5322828	40803235	10501331	76	1644											
ELF4	2000	broad.mit.edu	37	chrX	129200915	129200915	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtctggttgcccagaaggctCggattgtgggaacccctgga	15	10	1	1			TCGA-06-0154-01A-03D-1491-08	TCGA-06-0154-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	f5045707-3ddd-4ade-959a-b368437752fb	bfc36431-e6a1-4c02-98c1-6bcca13ea93b	g.chrX:129200915C>T	uc004evd.3	-	9	2158	c.1773G>A	c.(1771-1773)CCG>CCA	p.P591P	ELF4_uc004eve.3_Silent_p.P591P	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	591					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCAGAAGGCTCGGATTGTGGG	0.607			T	ERG	AML								T	129200915	T	T	129200915	2	4	25	1	0	0	0	0	0	0	0	1	5056	871	31	2		2	ELF4	23	129200915	Silent	SNP	C	TCGA-06-0154-01A-03D-1491-08		129200915	26069645	77	1645											
CLCNKB	1188	broad.mit.edu	37	chr1	16378751	16378751	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tccacggcgctgctggccttCgaggtgaccggccagatagt	14	13	0	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:16378751C>T	uc001axw.3	+	15	1547	c.1467C>T	c.(1465-1467)TTC>TTT	p.F489F	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.F489F|CLCNKB_uc001axy.3_Silent_p.F320F	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	489	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTGGCCTTCGAGGTGACCG	0.657													T	16378751	T	T	16378751	2	4	26	1	0	0	0	0	0	0	0	1	3470	883	31	2		2	CLCNKB	1	16378751	Silent	SNP	C	TCGA-06-0155-01B-01D-1492-08		16378751	232871870	1	1646											
KLF17	128209	broad.mit.edu	37	chr1	44595217	44595217	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggggccacagttcagtatgCcactgcctgagcgtggtatg	15	10	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:44595217C>T	uc001clp.2	+	2	332	c.274C>T	c.(274-276)CCA>TCA	p.P92S	KLF17_uc009vxf.1_Missense_Mutation_p.P55S	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	92					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GTTCAGTATGCCACTGCCTGA	0.567													T	44595217	T	T	44595217	3	4	26	1	0	0	0	0	1	0	0	0	8345	739	26	3	280	3	KLF17	1	44595217	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	28216466	44595217	204655404	2	1647											
TESK2	10420	broad.mit.edu	37	chr1	45923297	45923297	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtgaaatcatccaaacgcGtcagtctggaaaaggcactt	10	9	3	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:45923297G>A	uc001cns.1	-	2	564	c.161C>T	c.(160-162)ACG>ATG	p.T54M	TESK2_uc009vxr.1_Missense_Mutation_p.T54M|TESK2_uc010olo.1_Intron|TESK2_uc009vxs.1_Translation_Start_Site|TESK2_uc010olp.1_Missense_Mutation_p.T54M	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	54					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)					ATCCAAACGCGTCAGTCTGGA	0.453													A	45923297	A	A	45923297	3	1	26	1	0	0	0	0	1	0	0	0	15765	1145	40	1	1594	1	TESK2	1	45923297	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	1328080	45923297	203327324	3	1648											
AP4B1	10717	broad.mit.edu	37	chr1	114438528	114438528	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tattcacaggtctttctgccGgatcctccaaaagtccaaga	7	12	3	1	rs149723440		TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:114438528G>A	uc001eeb.2	-	9	1786	c.1643C>T	c.(1642-1644)CCG>CTG	p.P548L	uc001edv.1_Intron|AP4B1_uc001eec.2_Missense_Mutation_p.P380L|AP4B1_uc001eed.2_Missense_Mutation_p.P548L|AP4B1_uc010owp.1_Missense_Mutation_p.P449L|AP4B1_uc001eea.1_3'UTR|AP4B1_uc001eee.1_Missense_Mutation_p.P75L	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	548					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTTTCTGCCGGATCCTCCAA	0.498													A	114438528	A	A	114438528	3	1	26	1	0	0	0	0	1	0	0	0	751	1116	39	2	584	2	AP4B1	1	114438528	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	68515231	114438528	134812093	4	1649											
SPTA1	6708	broad.mit.edu	37	chr1	158653172	158653172	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tacatataccttcgtttcttCgtgggcagaatgacccatgg	9	10	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:158653172C>G	uc001fst.1	-	3	578	c.379G>C	c.(379-381)GAA>CAA	p.E127Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	127	Spectrin 2.			Missing (in Ref. 3; AAA60575).	actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTCGTTTCTTCGTGGGCAGAA	0.388													G	158653172	G	G	158653172	3	3	26	1	0	0	0	0	1	0	0	0	15115	893	31	5	7080	5	SPTA1	1	158653172	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	44214644	158653172	90597449	5	1650											
ANGPTL1	9068	broad.mit.edu	37	chr1	178834371	178834371	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attgacaagatcagtcaaggAagcgtatttcacctctagtt	8	8	4	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:178834371A>G	uc001gma.2	-	3	1017	c.541T>C	c.(541-543)TCC>CCC	p.S181P	RALGPS2_uc001gly.1_Intron|RALGPS2_uc001glz.2_Intron|RALGPS2_uc010pnb.1_Intron|ANGPTL1_uc001gmb.2_Missense_Mutation_p.S181P|ANGPTL1_uc010pnc.1_Missense_Mutation_p.S103P	NM_004673	NP_004664	O95841	ANGL1_HUMAN	angiopoietin-like 1 precursor	181						extracellular space	receptor binding				0						TCAGTCAAGGAAGCGTATTTC	0.423													G	178834371	G	G	178834371	3	3	26	1	0	0	0	0	1	0	0	0	613	246	9	4	950	4	ANGPTL1	1	178834371	Missense_Mutation	SNP	A	TCGA-06-0155-01B-01D-1492-08	20181199	178834371	70416250	6	1651											
OBSCN	84033	broad.mit.edu	37	chr1	228431145	228431145	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggccagagggtctccttccGcctgcacatcacaggtgggt	14	13	2	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:228431145G>T	uc009xez.1	+	10	3235	c.3191G>T	c.(3190-3192)CGC>CTC	p.R1064L	OBSCN_uc001hsn.2_Missense_Mutation_p.R1064L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1064	Ig-like 10.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GTCTCCTTCCGCCTGCACATC	0.552													T	228431145	T	T	228431145	3	4	26	1	0	0	0	0	1	0	0	0	10812	1087	38	5	3225	5	OBSCN	1	228431145	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	49596774	228431145	20819476	7	1652											
OBSCN	84033	broad.mit.edu	37	chr1	228557713	228557713	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaacgtcctggaggggcgcGtgtcatggagcagccccatg	16	11	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:228557713G>A	uc009xez.1	+	91	20082	c.20038G>A	c.(20038-20040)GTG>ATG	p.V6680M	OBSCN_uc001hsr.1_Missense_Mutation_p.V1309M	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6680	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGAGGGGCGCGTGTCATGGAG	0.642													A	228557713	A	A	228557713	3	1	26	1	0	0	0	0	1	0	0	0	10812	1145	40	1	21606	1	OBSCN	1	228557713	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	126568	228557713	20692908	8	1653											
CHRM3	1131	broad.mit.edu	37	chr1	240072235	240072235	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcggcccagaccctcagtgCgatcttgcttgccttcatca	9	15	4	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:240072235C>T	uc001hyp.2	+	5	2263	c.1484C>T	c.(1483-1485)GCG>GTG	p.A495V		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	495	Helical; Name=6; (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	ACCCTCAGTGCGATCTTGCTT	0.493													T	240072235	T	T	240072235	3	4	26	1	0	0	0	0	1	0	0	0	3378	768	27	1	1486	1	CHRM3	1	240072235	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	11514522	240072235	9178386	9	1654											
HNRNPU	3192	broad.mit.edu	37	chr1	245022048	245022050	+	In_Frame_Del	DEL	CAT	-	-													tacagcaaaacatgtaatcaCatcattttcatcaaactttt							TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr1:245022048_245022050delCAT	uc001iaz.1	-	6	1429_1431	c.1211_1213delATG	c.(1210-1215)GATGTG>GTG	p.D404del	HNRNPU_uc001iaw.1_5'Flank|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_In_Frame_Del_p.D128del|HNRNPU_uc001iba.1_In_Frame_Del_p.D385del|HNRNPU_uc001ibb.1_In_Frame_Del_p.D92del	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	404	B30.2/SPRY.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CATGTAATCACATCATTTTCATC	0.31													-	245022050	-	-	245022048	7	5	26	1	0	1	0	1	0	0	0	0	7273	478	17	0	1300	0	HNRNPU	1	245022048	In_Frame_Del	DEL	CAT	TCGA-06-0155-01B-01D-1492-08	4949813	245022048	4228573	10	1655											
CAPN13	92291	broad.mit.edu	37	chr2	30966369	30966369	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtcatggtgaagttgcggCggaatttattatttgagctt	12	4	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr2:30966369C>T	uc002rnn.2	-	12	1501	c.1325G>A	c.(1324-1326)CGC>CAC	p.R442H	CAPN13_uc002rnm.2_RNA|CAPN13_uc002rno.2_5'UTR	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	442					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GAAGTTGCGGCGGAATTTATT	0.463													T	30966369	T	T	30966369	3	4	26	1	0	0	0	0	1	0	0	0	2626	768	27	1	724	1	CAPN13	2	30966369	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08		30966369	212233004	11	1656											
LHCGR	3973	broad.mit.edu	37	chr2	48915170	48915170	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttgaaggcagctgagatgGcaaaaaaagagataggtgcc	13	6	0	3			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr2:48915170G>A	uc002rwu.3	-	11	1836	c.1766C>T	c.(1765-1767)GCC>GTC	p.A589V	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	589	Helical; Name=6; (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AGCTGAGATGGCAAAAAAAGA	0.383									Familial_Male-Limited_Precocious_Puberty				A	48915170	A	A	48915170	3	1	26	1	0	0	0	0	1	0	0	0	8762	1203	42	3	337	3	LHCGR	2	48915170	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	17948801	48915170	194284203	12	1657											
DYSF	8291	broad.mit.edu	37	chr2	71871111	71871111	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaggaggaagagttcatcgAttggtggagcaaattctttg	13	5	3	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr2:71871111A>C	uc002sie.2	+	41	4803	c.4427A>C	c.(4426-4428)GAT>GCT	p.D1476A	DYSF_uc010feg.2_Missense_Mutation_p.D1507A|DYSF_uc010feh.2_Missense_Mutation_p.D1483A|DYSF_uc002sig.3_Missense_Mutation_p.D1462A|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.D1497A|DYSF_uc010fef.2_Missense_Mutation_p.D1514A|DYSF_uc010fei.2_Missense_Mutation_p.D1493A|DYSF_uc010fek.2_Missense_Mutation_p.D1494A|DYSF_uc010fej.2_Missense_Mutation_p.D1484A|DYSF_uc010fel.2_Missense_Mutation_p.D1463A|DYSF_uc010feo.2_Missense_Mutation_p.D1508A|DYSF_uc010fem.2_Missense_Mutation_p.D1498A|DYSF_uc010fen.2_Missense_Mutation_p.D1515A|DYSF_uc002sif.2_Missense_Mutation_p.D1477A|DYSF_uc010yqy.1_Missense_Mutation_p.D357A|DYSF_uc010yqz.1_Missense_Mutation_p.D237A	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1476	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GAGTTCATCGATTGGTGGAGC	0.502													C	71871111	C	C	71871111	3	2	26	1	0	0	0	0	1	0	0	0	4859	333	12	5	4848	5	DYSF	2	71871111	Missense_Mutation	SNP	A	TCGA-06-0155-01B-01D-1492-08	22955941	71871111	171328262	13	1658											
SCN9A	6335	broad.mit.edu	37	chr2	167085353	167085353	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccgtgacccatctgtggtgtTaatacactcatagaacttgc	8	11	2	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr2:167085353T>A	uc010fpl.2	-	22	4362	c.4021A>T	c.(4021-4023)AAC>TAC	p.N1341Y	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1352	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCTGTGGTGTTAATACACTCA	0.403													A	167085353	A	A	167085353	3	1	26	1	0	0	0	0	1	0	0	0	13925	1754	61	5	1936	5	SCN9A	2	167085353	Missense_Mutation	SNP	T	TCGA-06-0155-01B-01D-1492-08	95214242	167085353	76114020	14	1659											
TTN	7273	broad.mit.edu	37	chr2	179437058	179437058	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtttcagcaggcagcccaaTgccatattcattttctgcga	9	11	3	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr2:179437058T>C	uc010zfg.1	-	275	66321	c.66097A>G	c.(66097-66099)ATT>GTT	p.I22033V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I15728V|TTN_uc010zfi.1_Missense_Mutation_p.I15661V|TTN_uc010zfj.1_Missense_Mutation_p.I15536V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22960							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCAGCCCAATGCCATATTCA	0.448													C	179437058	C	C	179437058	3	2	26	1	0	0	0	0	1	0	0	0	16732	1464	51	4	34326	4	TTN	2	179437058	Missense_Mutation	SNP	T	TCGA-06-0155-01B-01D-1492-08	12351705	179437058	63762315	15	1660											
CDHR4	389118	broad.mit.edu	37	chr3	49836331	49836331	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggtgtgactgtctctggCacctgaatcatttccccagc	9	14	2	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr3:49836331C>T	uc010hkz.2	-	4	432	c.423G>A	c.(421-423)GTG>GTA	p.V141V	CDHR4_uc003cxp.2_Missense_Mutation_p.A167T|CDHR4_uc011bcw.1_Silent_p.V141V	NM_001007540	NP_001007541	A6H8M9	CDHR4_HUMAN	cadherin-like 29 precursor	141	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						CTGTCTCTGGCACCTGAATCA	0.652													T	49836331	T	T	49836331	2	4	26	1	0	0	0	0	0	0	0	1	3121	697	25	3		3	CDHR4	3	49836331	Silent	SNP	C	TCGA-06-0155-01B-01D-1492-08		49836331	148186099	16	1661											
STAB1	23166	broad.mit.edu	37	chr3	52554842	52554842	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccctgaggcctgctggcGcttctacccgaagttctgga	12	14	2	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr3:52554842G>A	uc003dej.2	+	55	5803	c.5729G>A	c.(5728-5730)CGC>CAC	p.R1910H	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1910	Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCTGCTGGCGCTTCTACCCG	0.662													A	52554842	A	A	52554842	3	1	26	1	0	0	0	0	1	0	0	0	15236	1087	38	1	5947	1	STAB1	3	52554842	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	2718511	52554842	145467588	17	1662											
PROS1	5627	broad.mit.edu	37	chr3	93603713	93603713	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcatcaaattccagcttcGtatacatccatctagacgag	5	12	3	1	rs5017717		TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr3:93603713G>A	uc003drb.3	-	12	1692	c.1351C>T	c.(1351-1353)CGA>TGA	p.R451*	PROS1_uc010hoo.2_Nonsense_Mutation_p.R320*|PROS1_uc003dqz.3_Nonsense_Mutation_p.R320*	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	451	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTCCAGCTTCGTATACATCCA	0.358													A	93603713	A	A	93603713	4	1	26	1	0	0	0	0	0	1	0	0	12558	1153	40	1	695	1	PROS1	3	93603713	Nonsense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	41048871	93603713	104418717	18	1663											
ZIC1	7545	broad.mit.edu	37	chr3	147130368	147130368	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcgctaacagcagcgaccGcaagaagcacatgcacgtgc	10	14	0	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr3:147130368G>A	uc003ewe.2	+	2	1765	c.1046G>A	c.(1045-1047)CGC>CAC	p.R349H		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	349	C2H2-type 4.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGCAGCGACCGCAAGAAGCAC	0.542													A	147130368	A	A	147130368	3	1	26	1	0	0	0	0	1	0	0	0	17675	1087	38	1	1052	1	ZIC1	3	147130368	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	53526655	147130368	50892062	19	1664											
SULT1B1	27284	broad.mit.edu	37	chr4	70596339	70596339	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atggatgatcctatccaagaTctcatcattcaggttcttct	6	10	5	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr4:70596339T>G	uc003hen.2	-	7	956	c.658A>C	c.(658-660)ATC>CTC	p.I220L		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	220	PAPS (By similarity).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						CTATCCAAGATCTCATCATTC	0.363													G	70596339	G	G	70596339	3	3	26	1	0	0	0	0	1	0	0	0	15373	1435	50	5	240	5	SULT1B1	4	70596339	Missense_Mutation	SNP	T	TCGA-06-0155-01B-01D-1492-08		70596339	120557937	20	1665											
BMP3	651	broad.mit.edu	37	chr4	81967402	81967402	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgttcccaaatgggatagccAcatcagagctgccctttcca	8	13	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr4:81967402A>G	uc003hmg.3	+	2	1147	c.827A>G	c.(826-828)CAC>CGC	p.H276R		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	276					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						TGGGATAGCCACATCAGAGCT	0.517													G	81967402	G	G	81967402	3	3	26	1	0	0	0	0	1	0	0	0	1461	159	6	4	833	4	BMP3	4	81967402	Missense_Mutation	SNP	A	TCGA-06-0155-01B-01D-1492-08	11371063	81967402	109186874	21	1666											
QRFPR	84109	broad.mit.edu	37	chr4	122254151	122254151	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagatcttctggtgcacagGgctggtccactcttctaagc	11	11	4	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr4:122254151G>A	uc010inj.1	-	4	1001	c.622C>T	c.(622-624)CCT>TCT	p.P208S	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_Missense_Mutation_p.P208S	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	208	Extracellular (Potential).					plasma membrane	neuropeptide Y receptor activity				0						TGGTGCACAGGGCTGGTCCAC	0.388													A	122254151	A	A	122254151	3	1	26	1	0	0	0	0	1	0	0	0	12878	1232	43	3	685	3	QRFPR	4	122254151	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	40286749	122254151	68900125	22	1667											
CARD6	84674	broad.mit.edu	37	chr5	40853779	40853779	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcccagggccgaggtaaaaGttttggtattcaatccttcc	11	10	1	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr5:40853779G>A	uc003jmg.2	+	3	2420	c.2345G>A	c.(2344-2346)AGT>AAT	p.S782N		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	782					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						CGAGGTAAAAGTTTTGGTATT	0.488													A	40853779	A	A	40853779	3	1	26	1	0	0	0	0	1	0	0	0	2650	1029	36	3	2355	3	CARD6	5	40853779	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08		40853779	140061481	23	1668											
ADAMTS6	11174	broad.mit.edu	37	chr5	64766854	64766854	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggatcaatagggtccatactCcgtcttctccttgagtgttt	9	10	3	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr5:64766854C>T	uc003jtp.2	-	3	1027	c.213G>A	c.(211-213)CGG>CGA	p.R71R	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_5'UTR	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	71					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		GGTCCATACTCCGTCTTCTCC	0.383													T	64766854	T	T	64766854	2	4	26	1	0	0	0	0	0	0	0	1	270	842	30	3		3	ADAMTS6	5	64766854	Silent	SNP	C	TCGA-06-0155-01B-01D-1492-08	23913075	64766854	116148406	24	1669											
MAP1B	4131	broad.mit.edu	37	chr5	71494069	71494069	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatttctcccctaaaactgcAaagtccaggacacccgttca	6	14	2	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr5:71494069A>G	uc003kbw.3	+	5	5128	c.4887A>G	c.(4885-4887)GCA>GCG	p.A1629A	MAP1B_uc010iyw.1_Silent_p.A1646A|MAP1B_uc010iyx.1_Silent_p.A1503A|MAP1B_uc010iyy.1_Silent_p.A1503A	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1629						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTAAAACTGCAAAGTCCAGGA	0.438													G	71494069	G	G	71494069	2	3	26	1	0	0	0	0	0	0	0	1	9228	117	5	4		4	MAP1B	5	71494069	Silent	SNP	A	TCGA-06-0155-01B-01D-1492-08	6727215	71494069	109421191	25	1670											
PCDHGC3	5098	broad.mit.edu	37	chr5	140857767	140857770	+	Frame_Shift_Del	DEL	TTCT	-	-													aaatctcaccttttatctacTtctttctctaatcctggttt							TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr5:140857767_140857770delTTCT	uc003lkv.1	+	1	2199_2202	c.2084_2087delTTCT	c.(2083-2088)CTTCTTfs	p.L695fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Frame_Shift_Del_p.L695fs|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	695_696	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTATCTACTTCTTTCTCTAATC	0.49											OREG0016865	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	140857770	-	-	140857767	7	5	26	1	0	1	0	1	0	0	0	0	11569	1609	56	0	2086	0	PCDHGC3	5	140857767	Frame_Shift_Del	DEL	TTCT	TCGA-06-0155-01B-01D-1492-08	69363698	140857767	40057493	26	1671											
SGCD	6444	broad.mit.edu	37	chr5	155935645	155935645	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctgaggatcacagaaaaagGtctaaagctagaaggagact	11	7	2	4			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr5:155935645G>T	uc003lwd.3	+	3	700	c.224G>T	c.(223-225)GGT>GTT	p.G75V	SGCD_uc003lwa.1_Missense_Mutation_p.G76V|SGCD_uc003lwb.2_Missense_Mutation_p.G76V|SGCD_uc003lwc.3_Missense_Mutation_p.G76V	NM_001128209	NP_001121681	Q92629	SGCD_HUMAN	delta-sarcoglycan isoform 3	75	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACAGAAAAAGGTCTAAAGCTA	0.418													T	155935645	T	T	155935645	3	4	26	1	0	0	0	0	1	0	0	0	14201	1261	44	5	237	5	SGCD	5	155935645	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	15077878	155935645	24979615	27	1672											
FLT4	2324	broad.mit.edu	37	chr5	180048669	180048669	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctgagcgtggcgtggcgCgccccaggtgccacctcctc	15	16	0	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr5:180048669C>T	uc003mma.3	-	13	1972	c.1893G>A	c.(1891-1893)GCG>GCA	p.A631A	FLT4_uc003mlz.3_Silent_p.A631A|FLT4_uc003mmb.1_Silent_p.A164A|FLT4_uc011dgy.1_Silent_p.A631A	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	631	Ig-like C2-type 6.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGCGTGGCGCGCCCCAGGTG	0.672									Congenital_Hereditary_Lymphedema				T	180048669	T	T	180048669	2	4	26	1	0	0	0	0	0	0	0	1	5944	755	27	1		1	FLT4	5	180048669	Silent	SNP	C	TCGA-06-0155-01B-01D-1492-08	24113024	180048669	866591	28	1673											
ITPR3	3710	broad.mit.edu	37	chr6	33653882	33653882	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacaacttggtatgcgagaCgctgcagttcctggacatca	10	11	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr6:33653882C>T	uc011drk.1	+	42	5939	c.5720C>T	c.(5719-5721)ACG>ATG	p.T1907M	ITPR3_uc003oey.2_Translation_Start_Site	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1907	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GTATGCGAGACGCTGCAGTTC	0.592													T	33653882	T	T	33653882	3	4	26	1	0	0	0	0	1	0	0	0	7922	536	19	1	5886	1	ITPR3	6	33653882	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08		33653882	137461185	29	1674											
GLP1R	2740	broad.mit.edu	37	chr6	39024212	39024212	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggagacggtgcagaaatggCgagaataccgacgccagtgc	16	9	0	3	rs141990898		TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr6:39024212C>T	uc003ooj.3	+	2	178	c.118C>T	c.(118-120)CGA>TGA	p.R40*	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	40	Extracellular (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	GCAGAAATGGCGAGAATACCG	0.632													T	39024212	T	T	39024212	4	4	26	1	0	0	0	0	0	1	0	0	6452	760	27	1	124	1	GLP1R	6	39024212	Nonsense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	5370330	39024212	132090855	30	1675											
DST	667	broad.mit.edu	37	chr6	56505355	56505355	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtcctttgctgtacacagaAgaacattcgttccttaaggc	8	11	0	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr6:56505355A>G	uc003pdf.2	-	17	2005	c.1977T>C	c.(1975-1977)TCT>TCC	p.S659S	DST_uc003pcz.3_Silent_p.S481S|DST_uc011dxj.1_Silent_p.S510S|DST_uc011dxk.1_Silent_p.S521S|DST_uc011dxl.1_Silent_p.S510S|DST_uc003pcy.3_Silent_p.S155S|DST_uc003pdb.2_Silent_p.S155S|DST_uc003pdc.3_Silent_p.S155S|DST_uc003pdd.3_Silent_p.S155S|DST_uc003pde.2_Silent_p.S597S	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	481					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGTACACAGAAGAACATTCGT	0.388													G	56505355	G	G	56505355	2	3	26	1	0	0	0	0	0	0	0	1	4783	59	3	4		4	DST	6	56505355	Silent	SNP	A	TCGA-06-0155-01B-01D-1492-08	17481143	56505355	114609712	31	1676											
HSF2	3298	broad.mit.edu	37	chr6	122744040	122744040	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aatggctcatccagtctgacCtcagaagatccagtgaccat	8	12	3	4			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr6:122744040C>A	uc003pyu.2	+	9	1195	c.1008C>A	c.(1006-1008)ACC>ACA	p.T336T	HSF2_uc003pyv.2_Silent_p.T336T	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	336					response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		CCAGTCTGACCTCAGAAGATC	0.433													A	122744040	A	A	122744040	2	1	26	1	0	0	0	0	0	0	0	1	7396	668	24	5		5	HSF2	6	122744040	Silent	SNP	C	TCGA-06-0155-01B-01D-1492-08	66238685	122744040	48371027	32	1677											
QKI	9444	broad.mit.edu	37	chr6	163899861	163899861	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagaggacttacagccaaacAacttgaagcagaaaccggat	9	9	0	3			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr6:163899861A>C	uc003qui.2	+	3	886	c.335A>C	c.(334-336)CAA>CCA	p.Q112P	QKI_uc003que.2_Missense_Mutation_p.Q112P|QKI_uc003quf.2_Missense_Mutation_p.Q112P|QKI_uc003qug.2_Missense_Mutation_p.Q112P|QKI_uc003quh.2_Missense_Mutation_p.Q112P|QKI_uc003quj.2_Missense_Mutation_p.Q112P	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	112	KH.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		ACAGCCAAACAACTTGAAGCA	0.368													C	163899861	C	C	163899861	3	2	26	1	0	0	0	0	1	0	0	0	12873	130	5	5	345	5	QKI	6	163899861	Missense_Mutation	SNP	A	TCGA-06-0155-01B-01D-1492-08	41155821	163899861	7215206	33	1678											
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26236176	26236178	+	Splice_Site	DEL	CCT	-	-													aagaaacagaattaaaattaCctcctcttccactcctagaa							TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr7:26236176_26236178delCCT	uc003sxr.3	-	6	829	c.613_splice	c.e6+1	p.G205_splice	HNRNPA2B1_uc003sxs.3_Splice_Site_p.G193_splice	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1						RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ATTAAAATTACCTCCTCTTCCAC	0.379			T	ETV1	prostate								-	26236178	-	-	26236176	8	5	26	1	0	1	0	1	0	0	1	0	7259	521	18	0	471	0	HNRNPA2B1	7	26236176	Splice_Site	DEL	CCT	TCGA-06-0155-01B-01D-1492-08		26236176	132902487	34	1679											
EGFR	1956	broad.mit.edu	37	chr7	55223543	55223543	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtaattatgtggtgacagatCacggctcgtgcgtccgagcc	13	10	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr7:55223543C>T	uc003tqk.2	+	8	1156	c.910C>T	c.(910-912)CAC>TAC	p.H304Y	EGFR_uc003tqh.2_Missense_Mutation_p.H304Y|EGFR_uc003tqi.2_Missense_Mutation_p.H304Y|EGFR_uc003tqj.2_Missense_Mutation_p.H304Y|EGFR_uc010kzg.1_Missense_Mutation_p.H259Y|EGFR_uc011kco.1_Missense_Mutation_p.H251Y|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	304	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGTGACAGATCACGGCTCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55223543	T	T	55223543	3	4	26	1	0	0	0	0	1	0	0	0	4967	826	29	3	940	3	EGFR	7	55223543	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	28987367	55223543	103915120	35	1680											
TPST1	8460	broad.mit.edu	37	chr7	65751542	65751542	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatcaagccagtcaatgtagGagctctatcaaaatgggttg	10	7	4	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr7:65751542G>A	uc003tuw.2	+	3	1242	c.890G>A	c.(889-891)GGA>GAA	p.G297E	TPST1_uc010kzy.2_RNA|TPST1_uc010kzz.2_Missense_Mutation_p.G297E|TPST1_uc010laa.2_Missense_Mutation_p.G297E	NM_003596	NP_003587	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	297	Lumenal (Potential).				inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity				0						GTCAATGTAGGAGCTCTATCA	0.368													A	65751542	A	A	65751542	3	1	26	1	0	0	0	0	1	0	0	0	16424	1174	41	3	896	3	TPST1	7	65751542	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	10527999	65751542	93387121	36	1681											
SRPK2	6733	broad.mit.edu	37	chr7	104782641	104782641	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgactcgggaattttatgtcGtccatttggcaattcaccat	8	9	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr7:104782641G>A	uc003vct.2	-	10	1511	c.1324C>T	c.(1324-1326)CGA>TGA	p.R442*	SRPK2_uc003vcu.2_Nonsense_Mutation_p.R442*|SRPK2_uc003vcv.2_Nonsense_Mutation_p.R453*|SRPK2_uc003vcw.1_Nonsense_Mutation_p.R442*	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	442	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						ATTTTATGTCGTCCATTTGGC	0.448													A	104782641	A	A	104782641	4	1	26	1	0	0	0	0	0	1	0	0	15159	1153	40	1	766	1	SRPK2	7	104782641	Nonsense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	39031099	104782641	54356022	37	1682											
GPR37	2861	broad.mit.edu	37	chr7	124404927	124404927	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cccccagacaagtttcgtttCtggacgcaggggcgaccccg	12	15	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr7:124404927C>G	uc003vli.2	-	1	755	c.104G>C	c.(103-105)AGA>ACA	p.R35T		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	35	Extracellular (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						AGTTTCGTTTCTGGACGCAGG	0.647													G	124404927	G	G	124404927	3	3	26	1	0	0	0	0	1	0	0	0	6691	913	32	5	1745	5	GPR37	7	124404927	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	19622286	124404927	34733736	38	1683											
FGL1	2267	broad.mit.edu	37	chr8	17726189	17726189	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcaggatgaaaattccccGcaagggaatctccagctgtt	9	12	2	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr8:17726189G>A	uc003wxx.2	-	8	971	c.647C>T	c.(646-648)GCG>GTG	p.A216V	FGL1_uc003wxy.2_Missense_Mutation_p.A216V|FGL1_uc003wxz.2_Missense_Mutation_p.A215V|FGL1_uc003wya.2_Missense_Mutation_p.A216V|FGL1_uc003wyb.2_Missense_Mutation_p.A216V|FGL1_uc003wyc.2_Missense_Mutation_p.A216V|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Missense_Mutation_p.A266V|FGL1_uc003wyf.2_Missense_Mutation_p.A186V	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	216	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		AAAATTCCCCGCAAGGGAATC	0.453													A	17726189	A	A	17726189	3	1	26	1	0	0	0	0	1	0	0	0	5872	1087	38	1	299	1	FGL1	8	17726189	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08		17726189	128637833	39	1684											
DOCK5	80005	broad.mit.edu	37	chr8	25222153	25222153	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttccgcagggtttttctccGtgctataaatcagtttgctg	9	10	2	0	rs148483229	byFrequency	TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr8:25222153G>A	uc003xeg.2	+	30	3193	c.3056G>A	c.(3055-3057)CGT>CAT	p.R1019H	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.R733H|DOCK5_uc003xei.2_Missense_Mutation_p.R589H|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1019						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GTTTTTCTCCGTGCTATAAAT	0.413													A	25222153	A	A	25222153	3	1	26	1	0	0	0	0	1	0	0	0	4690	1145	40	1	3174	1	DOCK5	8	25222153	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	7495964	25222153	121141869	40	1685											
PCMTD1	115294	broad.mit.edu	37	chr8	52733157	52733157	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tgtttaactctctttcttttCcttttgggtggagccctttg	8	9	2	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr8:52733157C>A	uc003xqx.3	-	6	1169	c.828G>T	c.(826-828)AGG>AGT	p.R276S	PCMTD1_uc011ldm.1_Missense_Mutation_p.R146S|PCMTD1_uc003xqw.3_Missense_Mutation_p.R276S|PCMTD1_uc011ldn.1_Missense_Mutation_p.R88S|PCMTD1_uc010lya.2_Missense_Mutation_p.R200S	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	276						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				TCTTTCTTTTCCTTTTGGGTG	0.368													A	52733157	A	A	52733157	3	1	26	1	0	0	0	0	1	0	0	0	11586	854	30	5	249	5	PCMTD1	8	52733157	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	27511004	52733157	93630865	41	1686											
STK3	6788	broad.mit.edu	37	chr8	99718703	99718703	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	taattttcttaccctcattgGatgtatatcagcataaggag	7	7	3	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr8:99718703G>C	uc003yip.2	-	6	817	c.676C>G	c.(676-678)CCA>GCA	p.P226A	STK3_uc003yio.2_Missense_Mutation_p.P254A|STK3_uc010mbm.1_Intron	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	226	Protein kinase.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		ACCCTCATTGGATGTATATCA	0.348													C	99718703	C	C	99718703	3	2	26	1	0	0	0	0	1	0	0	0	15294	1174	41	5	823	5	STK3	8	99718703	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	46985546	99718703	46645319	42	1687											
ATAD2	29028	broad.mit.edu	37	chr8	124358469	124358469	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaatcctggttctcctactaTcaatattcttggtcgaaaag	6	9	3	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr8:124358469T>C	uc003yqh.3	-	18	2497	c.2389A>G	c.(2389-2391)ATA>GTA	p.I797V	ATAD2_uc011lii.1_Missense_Mutation_p.I588V|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.I797V	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	797					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TCTCCTACTATCAATATTCTT	0.353													C	124358469	C	C	124358469	3	2	26	1	0	0	0	0	1	0	0	0	1071	1435	50	4	1827	4	ATAD2	8	124358469	Missense_Mutation	SNP	T	TCGA-06-0155-01B-01D-1492-08	24639766	124358469	22005553	43	1688											
SPATC1	375686	broad.mit.edu	37	chr8	145095497	145095497	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tccactgagcccccccagtcGacccaggacccagagcctct	8	20	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr8:145095497G>A	uc011lkw.1	+	3	897	c.795G>A	c.(793-795)TCG>TCA	p.S265S	SPATC1_uc011lkx.1_Silent_p.S265S	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	265										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCCCCAGTCGACCCAGGACC	0.617													A	145095497	A	A	145095497	2	1	26	1	0	0	0	0	0	0	0	1	15016	1045	37	2		2	SPATC1	8	145095497	Silent	SNP	G	TCGA-06-0155-01B-01D-1492-08	20737028	145095497	1268525	44	1689											
PRKCQ	5588	broad.mit.edu	37	chr10	6553040	6553040	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtttcagagatgaggtccaCgtttttgcctttcacaatga	10	8	2	3	rs148376969		TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr10:6553040C>T	uc001ijj.1	-	3	310	c.235G>A	c.(235-237)GTG>ATG	p.V79M	PRKCQ_uc009xim.1_Missense_Mutation_p.V79M|PRKCQ_uc001iji.1_Missense_Mutation_p.V112M|PRKCQ_uc009xin.1_Missense_Mutation_p.V43M|PRKCQ_uc010qax.1_Translation_Start_Site	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	79	C2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						ATGAGGTCCACGTTTTTGCCT	0.478													T	6553040	T	T	6553040	3	4	26	1	0	0	0	0	1	0	0	0	12515	536	19	1	1949	1	PRKCQ	10	6553040	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08		6553040	128981707	45	1690											
USP6NL	9712	broad.mit.edu	37	chr10	11505268	11505268	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagctccgggcctggcacGttgtcgtactgcgatgcagt	13	13	0	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr10:11505268G>A	uc001ikt.3	-	15	1980	c.1659C>T	c.(1657-1659)AAC>AAT	p.N553N	USP6NL_uc001iks.1_Silent_p.N570N	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	553						intracellular	Rab GTPase activator activity				0						GGCCTGGCACGTTGTCGTACT	0.662													A	11505268	A	A	11505268	2	1	26	1	0	0	0	0	0	0	0	1	17084	1136	40	1		1	USP6NL	10	11505268	Silent	SNP	G	TCGA-06-0155-01B-01D-1492-08	4952228	11505268	124029479	46	1691											
PPP3CB	5532	broad.mit.edu	37	chr10	75204531	75204531	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	taacactccactaggcaacaTccctgtgggagtcaggccct	9	14	1	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr10:75204531T>A	uc001jue.2	-	12	1453	c.1318A>T	c.(1318-1320)ATG>TTG	p.M440L	PPP3CB_uc001juf.2_Missense_Mutation_p.M441L|PPP3CB_uc001jug.2_Missense_Mutation_p.M441L|PPP3CB_uc001jui.2_Missense_Mutation_p.M458L|PPP3CB_uc001juh.2_Missense_Mutation_p.M355L|PPP3CB_uc010qkj.1_Missense_Mutation_p.M68L	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	440										skin(1)	1	Prostate(51;0.0119)					CTAGGCAACATCCCTGTGGGA	0.483													A	75204531	A	A	75204531	3	1	26	1	0	0	0	0	1	0	0	0	12398	1435	50	5	268	5	PPP3CB	10	75204531	Missense_Mutation	SNP	T	TCGA-06-0155-01B-01D-1492-08	63699263	75204531	60330216	47	1692											
PTEN	5728	broad.mit.edu	37	chr10	89692922	89692922	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gacgaactggtgtaatgataTgtgcatatttattacatcgg	10	5	0	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr10:89692922T>C	uc001kfb.2	+	6	1437	c.406T>C	c.(406-408)TGT>CGT	p.C136R		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	136	Phosphatase tensin-type.		C -> Y (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P3).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.C136Y(7)|p.R55fs*1(4)|p.C136F(3)|p.I135fs*44(3)|p.C136fs*1(2)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.C136R(2)|p.I135_A137>T(1)|p.A121_F145del(1)|p.I135fs*6(1)|p.C136_A137insGM(1)|p.C136W(1)|p.T131fs*42(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGTAATGATATGTGCATATTT	0.388		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89692922	C	C	89692922	3	2	26	1	0	0	0	0	1	0	0	0	12738	1464	51	4	424	4	PTEN	10	89692922	Missense_Mutation	SNP	T	TCGA-06-0155-01B-01D-1492-08	14488391	89692922	45841825	48	1693											
MMP21	118856	broad.mit.edu	37	chr10	127456157	127456157	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tcggtcataaaacgccgtgtCtaggggacttgggatgccag	14	9	2	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr10:127456157C>G	uc001liu.2	-	6	1354	c.1354G>C	c.(1354-1356)GAC>CAC	p.D452H		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	452	Hemopexin-like 3.				proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AACGCCGTGTCTAGGGGACTT	0.443													G	127456157	G	G	127456157	3	3	26	1	0	0	0	0	1	0	0	0	9660	913	32	5	363	5	MMP21	10	127456157	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	37763235	127456157	8078590	49	1694											
OR52E6	390078	broad.mit.edu	37	chr11	5862602	5862602	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcacagtaagtatgagggaTgatacgatgtccacagaagg	12	7	1	3			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr11:5862602T>G	uc010qzq.1	-	1	526	c.526A>C	c.(526-528)ATC>CTC	p.I176L	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTATGAGGGATGATACGATGT	0.483													G	5862602	G	G	5862602	3	3	26	1	0	0	0	0	1	0	0	0	11117	1464	51	5	417	5	OR52E6	11	5862602	Missense_Mutation	SNP	T	TCGA-06-0155-01B-01D-1492-08		5862602	129143914	50	1695											
CD44	960	broad.mit.edu	37	chr11	35232846	35232846	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaatcattctgaaggctcaActactttactggaaggttat	7	8	3	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr11:35232846A>G	uc001mvu.2	+	14	2094	c.1660A>G	c.(1660-1662)ACT>GCT	p.T554A	CD44_uc001mvv.2_Missense_Mutation_p.T511A|CD44_uc001mvw.2_Missense_Mutation_p.T305A|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Missense_Mutation_p.T241A|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron|CD44_uc010res.1_Missense_Mutation_p.T118A|CD44_uc010ret.1_RNA|CD44_uc010reu.1_Missense_Mutation_p.T82A	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	554	Extracellular (Potential).|Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	TGAAGGCTCAACTACTTTACT	0.463													G	35232846	G	G	35232846	3	3	26	1	0	0	0	0	1	0	0	0	3017	43	2	4	1714	4	CD44	11	35232846	Missense_Mutation	SNP	A	TCGA-06-0155-01B-01D-1492-08	29370244	35232846	99773670	51	1696											
SLC22A9	114571	broad.mit.edu	37	chr11	63149746	63149746	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatctccctcctgtcctttaCgaggtaagcttcatgcagtg	9	12	2	0	rs141060614		TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr11:63149746C>T	uc001nww.2	+	6	1338	c.1070C>T	c.(1069-1071)ACG>ATG	p.T357M	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	357	Helical; (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						CTGTCCTTTACGAGGTAAGCT	0.403													T	63149746	T	T	63149746	3	4	26	1	0	0	0	0	1	0	0	0	14461	536	19	1	1092	1	SLC22A9	11	63149746	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	27916900	63149746	71856770	52	1697											
HTR3A	3359	broad.mit.edu	37	chr11	113853886	113853886	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcccgtacgtgtatattcGgcatcaaggcgaagttcaga	10	9	2	1	rs149715642		TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr11:113853886G>A	uc010rxb.1	+	5	670	c.437G>A	c.(436-438)CGG>CAG	p.R146Q	HTR3A_uc010rxa.1_Missense_Mutation_p.R146Q|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Missense_Mutation_p.R125Q	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	140	Extracellular (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GTGTATATTCGGCATCAAGGC	0.542													A	113853886	A	A	113853886	3	1	26	1	0	0	0	0	1	0	0	0	7444	1116	39	2	481	2	HTR3A	11	113853886	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	50704140	113853886	21152630	53	1698											
CACNA1C	775	broad.mit.edu	37	chr12	2566754	2566754	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctttttagtgcaattttagaAcaagcaaccaaagcagatgg	8	7	0	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr12:2566754A>G	uc009zdu.1	+	5	952	c.639A>G	c.(637-639)GAA>GAG	p.E213E	CACNA1C_uc009zdv.1_Silent_p.E213E|CACNA1C_uc001qkb.2_Silent_p.E213E|CACNA1C_uc001qkc.2_Silent_p.E213E|CACNA1C_uc001qke.2_Silent_p.E213E|CACNA1C_uc001qkf.2_Silent_p.E213E|CACNA1C_uc001qjz.2_Silent_p.E213E|CACNA1C_uc001qkd.2_Silent_p.E213E|CACNA1C_uc001qkg.2_Silent_p.E213E|CACNA1C_uc009zdw.1_Silent_p.E213E|CACNA1C_uc001qkh.2_Silent_p.E213E|CACNA1C_uc001qkl.2_Silent_p.E213E|CACNA1C_uc001qkn.2_Silent_p.E213E|CACNA1C_uc001qko.2_Silent_p.E213E|CACNA1C_uc001qkp.2_Silent_p.E213E|CACNA1C_uc001qkr.2_Silent_p.E213E|CACNA1C_uc001qku.2_Silent_p.E213E|CACNA1C_uc001qkq.2_Silent_p.E213E|CACNA1C_uc001qks.2_Silent_p.E213E|CACNA1C_uc001qkt.2_Silent_p.E213E|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_5'UTR|CACNA1C_uc001qkj.1_5'UTR|CACNA1C_uc001qkk.1_5'UTR|CACNA1C_uc001qkm.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	213	Extracellular (Potential).|I.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CAATTTTAGAACAAGCAACCA	0.557													G	2566754	G	G	2566754	2	3	26	1	0	0	0	0	0	0	0	1	2540	40	2	4		4	CACNA1C	12	2566754	Silent	SNP	A	TCGA-06-0155-01B-01D-1492-08		2566754	131285141	54	1699											
PPFIBP1	8496	broad.mit.edu	37	chr12	27809558	27809558	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtaacttgtaggatgaactgGcatctttaaaagaacaacta	8	6	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr12:27809558G>A	uc001ric.1	+	10	1176	c.799G>A	c.(799-801)GCA>ACA	p.A267T	PPFIBP1_uc010sjr.1_Missense_Mutation_p.A95T|PPFIBP1_uc001rib.1_Missense_Mutation_p.A236T|PPFIBP1_uc001ria.2_Missense_Mutation_p.A236T|PPFIBP1_uc001rid.1_Missense_Mutation_p.A114T|PPFIBP1_uc001rie.1_5'Flank	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	267	Potential.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					GGATGAACTGGCATCTTTAAA	0.323													A	27809558	A	A	27809558	3	1	26	1	0	0	0	0	1	0	0	0	12313	1203	42	3	774	3	PPFIBP1	12	27809558	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	25242804	27809558	106042337	55	1700											
MDM2	4193	broad.mit.edu	37	chr12	69210697	69210697	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctaggagatttgtttggcGtgccaagcttctctgtgaaa	11	7	2	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr12:69210697G>A	uc001sui.2	+	4	567	c.280G>A	c.(280-282)GTG>ATG	p.V94M	MDM2_uc009zri.2_Intron|MDM2_uc009zqx.2_Missense_Mutation_p.V94M|MDM2_uc009zqw.2_Missense_Mutation_p.V94M|MDM2_uc001suk.2_Intron|MDM2_uc009zqy.1_Missense_Mutation_p.V83M|MDM2_uc001sun.3_Intron|MDM2_uc009zqz.2_Missense_Mutation_p.V88M|MDM2_uc009zra.2_Intron|MDM2_uc009zrb.1_RNA|MDM2_uc001sum.1_Intron|MDM2_uc009zrd.2_Intron|MDM2_uc009zrc.2_Intron|MDM2_uc009zre.2_Intron|MDM2_uc009zrf.2_Intron|MDM2_uc001suo.2_Intron|MDM2_uc009zrg.2_Intron|MDM2_uc009zrh.2_Intron	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2	88	Necessary for interaction with USP2.|SWIB.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TTTGTTTGGCGTGCCAAGCTT	0.363			A		sarcoma|glioma|colorectal|other								A	69210697	A	A	69210697	3	1	26	1	0	0	0	0	1	0	0	0	9413	1145	40	1	294	1	MDM2	12	69210697	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	41401139	69210697	64641198	56	1701											
TPH2	121278	broad.mit.edu	37	chr12	72366329	72366329	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	attcccagggtggagtatacTgaagaagaaactaaaacttg	10	6	0	3			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr12:72366329T>A	uc009zrw.1	+	6	780	c.639T>A	c.(637-639)ACT>ACA	p.T213T	TPH2_uc001swy.2_Silent_p.T123T	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	213					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	TGGAGTATACTGAAGAAGAAA	0.428													A	72366329	A	A	72366329	2	1	26	1	0	0	0	0	0	0	0	1	16399	1567	55	5		5	TPH2	12	72366329	Silent	SNP	T	TCGA-06-0155-01B-01D-1492-08	3155632	72366329	61485566	57	1702											
MYF5	4617	broad.mit.edu	37	chr12	81111228	81111228	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatcctcaggaatgccatccGctacatcgagagcctgcagg	11	13	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr12:81111228G>A	uc001szg.2	+	1	521	c.386G>A	c.(385-387)CGC>CAC	p.R129H		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	129	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						AATGCCATCCGCTACATCGAG	0.587													A	81111228	A	A	81111228	3	1	26	1	0	0	0	0	1	0	0	0	10027	1087	38	1	388	1	MYF5	12	81111228	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	8744899	81111228	52740667	58	1703											
STAB2	55576	broad.mit.edu	37	chr12	104089589	104089589	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ccaaacaacaatgccatcgaGaattacatcagggagaagaa	8	9	1	3			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr12:104089589G>T	uc001tjw.2	+	33	3735	c.3549G>T	c.(3547-3549)GAG>GAT	p.E1183D		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1183	Extracellular (Potential).|FAS1 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ATGCCATCGAGAATTACATCA	0.403													T	104089589	T	T	104089589	3	4	26	1	0	0	0	0	1	0	0	0	15237	933	33	5	3679	5	STAB2	12	104089589	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	22978361	104089589	29762306	59	1704											
LHX5	64211	broad.mit.edu	37	chr12	113905175	113905175	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcctccgggcgcctagggCgctcagctgtttcatccggc	14	15	2	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr12:113905175C>T	uc001tvj.1	-	4	1301	c.727G>A	c.(727-729)GCC>ACC	p.A243T		NM_022363	NP_071758	Q9H2C1	LHX5_HUMAN	LIM homeobox protein 5	243						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCGCCTAGGGCGCTCAGCTGT	0.652													T	113905175	T	T	113905175	3	4	26	1	0	0	0	0	1	0	0	0	8774	768	27	1	489	1	LHX5	12	113905175	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	9815586	113905175	19946720	60	1705											
RIMBP2	23504	broad.mit.edu	37	chr12	130927111	130927111	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgaagttctgatcctgctcGttccccagcgtgcttgccaa	9	13	1	2	rs142303116	byFrequency	TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr12:130927111G>A	uc001uil.2	-	8	899	c.735C>T	c.(733-735)AAC>AAT	p.N245N	RIMBP2_uc001uim.2_Silent_p.N153N|RIMBP2_uc001uin.1_Translation_Start_Site	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	245						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GATCCTGCTCGTTCCCCAGCG	0.602													A	130927111	A	A	130927111	2	1	26	1	0	0	0	0	0	0	0	1	13363	1136	40	1		1	RIMBP2	12	130927111	Silent	SNP	G	TCGA-06-0155-01B-01D-1492-08	17021936	130927111	2924784	61	1706											
COG6	57511	broad.mit.edu	37	chr13	40293942	40293942	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttgaattcactgacagacGtctggaaatgctacagtttc	8	8	2	3			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr13:40293942G>A	uc001uxh.2	+	15	1662	c.1562G>A	c.(1561-1563)CGT>CAT	p.R521H	COG6_uc001uxi.2_Missense_Mutation_p.R469H|COG6_uc010acb.2_Missense_Mutation_p.R521H	NM_020751	NP_065802	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6 isoform	521					protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		ACTGACAGACGTCTGGAAATG	0.343													A	40293942	A	A	40293942	3	1	26	1	0	0	0	0	1	0	0	0	3662	1145	40	1	1620	1	COG6	13	40293942	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08		40293942	74875936	62	1707											
FANCM	57697	broad.mit.edu	37	chr14	45657010	45657010	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaatgagagctatttacatgAaatctttgcgtagtccaatg	8	6	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr14:45657010A>G	uc001wwd.3	+	19	4798	c.4699A>G	c.(4699-4701)AAA>GAA	p.K1567E	FANCM_uc010anf.2_Missense_Mutation_p.K1541E|FANCM_uc001wwe.3_Missense_Mutation_p.K1103E|FANCM_uc010ang.2_Missense_Mutation_p.K781E	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1567					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TATTTACATGAAATCTTTGCG	0.254								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				G	45657010	G	G	45657010	3	3	26	1	0	0	0	0	1	0	0	0	5671	247	9	4	4773	4	FANCM	14	45657010	Missense_Mutation	SNP	A	TCGA-06-0155-01B-01D-1492-08		45657010	61692530	63	1708											
TBPL2	387332	broad.mit.edu	37	chr14	55907173	55907173	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctcctgctccatggaccGtaatcccactgttgggggtg	11	14	0	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr14:55907173G>A	uc001xby.2	-	1	91	c.91C>T	c.(91-93)CGG>TGG	p.R31W		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	31					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						TCCATGGACCGTAATCCCACT	0.657													A	55907173	A	A	55907173	3	1	26	1	0	0	0	0	1	0	0	0	15643	1144	40	1	1064	1	TBPL2	14	55907173	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	10250163	55907173	51442367	64	1709											
EHD4	30844	broad.mit.edu	37	chr15	42193062	42193062	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcaccatctccttcttggcGttgacacctgatatcttgcc	7	14	4	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr15:42193062G>A	uc001zot.2	-	6	1470	c.1407C>T	c.(1405-1407)AAC>AAT	p.N469N		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	469	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		CCTTCTTGGCGTTGACACCTG	0.592													A	42193062	A	A	42193062	2	1	26	1	0	0	0	0	0	0	0	1	4980	1136	40	1		1	EHD4	15	42193062	Silent	SNP	G	TCGA-06-0155-01B-01D-1492-08		42193062	60338330	65	1710											
RAB11FIP3	9727	broad.mit.edu	37	chr16	553082	553082	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcatggagggcccagaggaGgacattgctgacaaggtagg	16	8	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr16:553082G>A	uc002chf.2	+	7	1719	c.1380G>A	c.(1378-1380)GAG>GAA	p.E460E	RAB11FIP3_uc010uuf.1_Silent_p.E164E|RAB11FIP3_uc010uug.1_Silent_p.E195E	NM_014700	NP_055515	O75154	RFIP3_HUMAN	rab11-family interacting protein 3 isoform 1	460					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding				0		Hepatocellular(16;0.0218)				GCCCAGAGGAGGACATTGCTG	0.622													A	553082	A	A	553082	2	1	26	1	0	0	0	0	0	0	0	1	12895	991	35	3		3	RAB11FIP3	16	553082	Silent	SNP	G	TCGA-06-0155-01B-01D-1492-08		553082	89801671	66	1711											
SCNN1G	6340	broad.mit.edu	37	chr16	23226531	23226531	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctctatcattgcccgccGccagtggcagaaagccaagg	10	14	2	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr16:23226531G>A	uc002dlm.1	+	13	1830	c.1691G>A	c.(1690-1692)CGC>CAC	p.R564H		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	564	Cytoplasmic (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	ATTGCCCGCCGCCAGTGGCAG	0.587													A	23226531	A	A	23226531	3	1	26	1	0	0	0	0	1	0	0	0	13930	1087	38	1	1737	1	SCNN1G	16	23226531	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	22673449	23226531	67128222	67	1712											
CES1	1066	broad.mit.edu	37	chr16	55853460	55853460	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacctaccattttcaatgtcGtctccaagagctcctcttcc	4	15	3	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr16:55853460G>A	uc002eim.2	-	7	998	c.890C>T	c.(889-891)ACG>ATG	p.T297M	CES1_uc010ccf.2_5'Flank|CES1_uc002eil.2_Missense_Mutation_p.T298M|CES1_uc002ein.2_Missense_Mutation_p.T297M	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	297					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	TTTCAATGTCGTCTCCAAGAG	0.507													A	55853460	A	A	55853460	3	1	26	1	0	0	0	0	1	0	0	0	3269	1145	40	1	845	1	CES1	16	55853460	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	32626929	55853460	34501293	68	1713											
CES8	283848	broad.mit.edu	37	chr16	67040719	67040719	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccaactttgcccgcacaGggtgagtctgccccccagca	12	16	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr16:67040719G>A	uc002eqv.2	+	11	1349	c.1306G>A	c.(1306-1308)GGA>AGA	p.G436R	CES8_uc010vix.1_Intron|CES8_uc002eqw.2_Intron|CES8_uc002eqy.2_Missense_Mutation_p.G408R|CES8_uc002eqx.2_Missense_Mutation_p.G312R|CES8_uc010viy.1_Intron|CES8_uc010viz.1_Missense_Mutation_p.G408R|CES8_uc002eqz.2_Intron	NM_173815	NP_776176	Q5XG92	EST4A_HUMAN	carboxylesterase 8 (putative)	506						extracellular region	carboxylesterase activity				0						TGCCCGCACAGGGTGAGTCTG	0.567													A	67040719	A	A	67040719	3	1	26	1	0	0	0	0	1	0	0	0	3273	1014	35	3	1647	3	CES8	16	67040719	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08	11187259	67040719	23314034	69	1714											
THRA	7067	broad.mit.edu	37	chr17	38240101	38240101	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accccagggcttctttcgccGcacaatccagaagaacctcc	7	17	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr17:38240101G>A	uc002htw.2	+	5	719	c.236G>A	c.(235-237)CGC>CAC	p.R79H	THRA_uc010cwp.1_Missense_Mutation_p.R79H|THRA_uc002htv.2_Missense_Mutation_p.R79H|THRA_uc002htx.2_Missense_Mutation_p.R79H	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	79	Nuclear receptor.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	TTCTTTCGCCGCACAATCCAG	0.547													A	38240101	A	A	38240101	3	1	26	1	0	0	0	0	1	0	0	0	15870	1087	38	1	250	1	THRA	17	38240101	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08		38240101	42955109	70	1715											
ASPSCR1	79058	broad.mit.edu	37	chr17	79953896	79953896	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaagctgccctgcggggcaCgacgctgcagtcgctgggcc	16	14	0	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr17:79953896C>T	uc002kcx.2	+	6	558	c.461C>T	c.(460-462)ACG>ATG	p.T154M	ASPSCR1_uc002kcw.1_Missense_Mutation_p.T154M|ASPSCR1_uc002kcy.2_Missense_Mutation_p.T154M|ASPSCR1_uc002kcz.2_Missense_Mutation_p.T154M|ASPSCR1_uc002kda.2_Missense_Mutation_p.T77M|ASPSCR1_uc002kdb.1_Missense_Mutation_p.T77M	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	154							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CTGCGGGGCACGACGCTGCAG	0.657			T	TFE3	alveolar soft part sarcoma								T	79953896	T	T	79953896	3	4	26	1	0	0	0	0	1	0	0	0	1059	536	19	1	483	1	ASPSCR1	17	79953896	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	41713795	79953896	1241314	71	1716											
MIB1	57534	broad.mit.edu	37	chr18	19345780	19345780	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atacctgccgccagcaaccaAtcattggcattcgatggaag	9	12	1	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr18:19345780A>G	uc002ktq.2	+	2	277	c.277A>G	c.(277-279)ATC>GTC	p.I93V	MIB1_uc002ktp.2_5'UTR	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	93	ZZ-type.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			CCAGCAACCAATCATTGGCAT	0.378													G	19345780	G	G	19345780	3	3	26	1	0	0	0	0	1	0	0	0	9566	101	4	4	283	4	MIB1	18	19345780	Missense_Mutation	SNP	A	TCGA-06-0155-01B-01D-1492-08		19345780	58731468	72	1717											
LMAN1	3998	broad.mit.edu	37	chr18	57022801	57022801	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cacctcaacttcccagttctCaaaggccgcttttgtctttg	6	14	3	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr18:57022801C>A	uc002lhz.2	-	2	336	c.304G>T	c.(304-306)GAG>TAG	p.E102*	LMAN1_uc010xek.1_Nonsense_Mutation_p.E102*	NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor	102	Lumenal (Potential).|L-type lectin-like.				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	TCCCAGTTCTCAAAGGCCGCT	0.413													A	57022801	A	A	57022801	4	1	26	1	0	0	0	0	0	1	0	0	8836	835	29	5	1276	5	LMAN1	18	57022801	Nonsense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	37677021	57022801	21054447	73	1718											
MUM1	84939	broad.mit.edu	37	chr19	1357015	1357015	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttttaaatgtaggttttggCccgaaccgcgacttcaacaa	9	9	1	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr19:1357015C>T	uc010xgm.1	+	2	134	c.65C>T	c.(64-66)GCC>GTC	p.A22V	MUM1_uc010dsi.2_5'UTR|MUM1_uc002lrz.2_Missense_Mutation_p.A23V|MUM1_uc002lsb.2_5'UTR|MUM1_uc002lsc.1_5'Flank			Q2TAK8	MUM1_HUMAN	SubName: Full=MUM1 protein;	22					chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGGTTTTGGCCCGAACCGCG	0.353													T	1357015	T	T	1357015	3	4	26	1	0	0	0	0	1	0	0	0	9985	739	26	3	74	3	MUM1	19	1357015	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08		1357015	57771968	74	1719											
TUBB4	10382	broad.mit.edu	37	chr19	6502176	6502176	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tccccgagcaccttggccccGatctggttgccgcactggcc	11	18	1	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr19:6502176G>T	uc002mfg.1	-	1	155	c.48C>A	c.(46-48)ATC>ATA	p.I16I	TUBB4_uc002mff.1_5'UTR	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	16					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		CCTTGGCCCCGATCTGGTTGC	0.547													T	6502176	T	T	6502176	2	4	26	1	0	0	0	0	0	0	0	1	16755	1048	37	5		5	TUBB4	19	6502176	Silent	SNP	G	TCGA-06-0155-01B-01D-1492-08	5145161	6502176	52626807	75	1720											
CD209	30835	broad.mit.edu	37	chr19	7807928	7807928	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagggggtgaagttctgctaCgcaggaggggggtttggggt	21	4	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr19:7807928C>T	uc002mht.2	-	7	1279	c.1212G>A	c.(1210-1212)GCG>GCA	p.A404A	CD209_uc010xju.1_Silent_p.A243A|CD209_uc010dvp.2_3'UTR|CD209_uc002mhr.2_Silent_p.A380A|CD209_uc002mhs.2_Silent_p.A334A|CD209_uc002mhu.2_Silent_p.A312A|CD209_uc010dvq.2_Silent_p.A398A|CD209_uc002mhq.2_Silent_p.A404A|CD209_uc002mhv.2_Silent_p.A380A|CD209_uc002mhx.2_Silent_p.A360A|CD209_uc002mhw.2_Silent_p.A268A|CD209_uc010dvr.2_Silent_p.A168A	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	404	Extracellular (Probable).				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						AGTTCTGCTACGCAGGAGGGG	0.502													T	7807928	T	T	7807928	2	4	26	1	0	0	0	0	0	0	0	1	2984	523	19	1		1	CD209	19	7807928	Silent	SNP	C	TCGA-06-0155-01B-01D-1492-08	1305752	7807928	51321055	76	1721											
AKAP8	10270	broad.mit.edu	37	chr19	15484143	15484143	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggactcgaacggctggaagCggaaggagctgcaacagaag	16	8	0	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr19:15484143C>T	uc002nav.2	-	5	441	c.380G>A	c.(379-381)CGC>CAC	p.R127H	AKAP8_uc010dzy.2_5'UTR|AKAP8_uc010dzz.1_RNA|AKAP8_uc010xog.1_5'UTR	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	127					signal transduction	nuclear matrix				ovary(1)|breast(1)	2						CGGCTGGAAGCGGAAGGAGCT	0.607													T	15484143	T	T	15484143	3	4	26	1	0	0	0	0	1	0	0	0	457	768	27	1	1738	1	AKAP8	19	15484143	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	7676215	15484143	43644840	77	1722											
OR10H4	126541	broad.mit.edu	37	chr19	16060302	16060302	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catggggatgatggtgacaaCgatagttttccacctcactt	10	9	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr19:16060302C>T	uc010xov.1	+	1	485	c.485C>T	c.(484-486)ACG>ATG	p.T162M		NM_001004465	NP_001004465	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T162T(1)		ovary(1)|breast(1)	2						ATGGTGACAACGATAGTTTTC	0.502													T	16060302	T	T	16060302	3	4	26	1	0	0	0	0	1	0	0	0	10908	536	19	1	487	1	OR10H4	19	16060302	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	576159	16060302	43068681	78	1723											
RCN3	57333	broad.mit.edu	37	chr19	50042431	50042431	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctatgtccaggtggaggagtAcatcggtgagtgggccccaa	15	9	0	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr19:50042431A>G	uc002poj.2	+	5	1121	c.674A>G	c.(673-675)TAC>TGC	p.Y225C		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	225	EF-hand 4.					endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		GTGGAGGAGTACATCGGTGAG	0.587													G	50042431	G	G	50042431	3	3	26	1	0	0	0	0	1	0	0	0	13181	391	14	4	688	4	RCN3	19	50042431	Missense_Mutation	SNP	A	TCGA-06-0155-01B-01D-1492-08	33982129	50042431	9086552	79	1724											
SIGLEC11	114132	broad.mit.edu	37	chr19	50453362	50453362	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tcctggtccgcaggctcccaGagcctcaggccctggaagct	12	16	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr19:50453362G>T	uc010ybh.1	-	11	2053	c.1962C>A	c.(1960-1962)CTC>CTA	p.L654L	SIGLEC11_uc010ybi.1_Silent_p.L558L	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	654	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CAGGCTCCCAGAGCCTCAGGC	0.662													T	50453362	T	T	50453362	2	4	26	1	0	0	0	0	0	0	0	1	14307	929	33	5		5	SIGLEC11	19	50453362	Silent	SNP	G	TCGA-06-0155-01B-01D-1492-08	410931	50453362	8675621	80	1725											
RBL1	5933	broad.mit.edu	37	chr20	35663716	35663716	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggccattgttagaagagttTgaccaggtaaaattgataca	10	5	0	4			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr20:35663716T>A	uc002xgi.2	-	15	2178	c.2099A>T	c.(2098-2100)CAA>CTA	p.Q700L	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.Q700L	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	700	Pocket; binds T and E1A.|Spacer.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				TAGAAGAGTTTGACCAGGTAA	0.363													A	35663716	A	A	35663716	3	1	26	1	0	0	0	0	1	0	0	0	13109	1812	63	5	1148	5	RBL1	20	35663716	Missense_Mutation	SNP	T	TCGA-06-0155-01B-01D-1492-08		35663716	27361804	81	1726											
DSCAM	1826	broad.mit.edu	37	chr21	41514514	41514514	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgaggttggcccagtaaatgActctgaacccctggagaatt	11	9	1	4			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr21:41514514A>T	uc002yyq.1	-	18	3829	c.3377T>A	c.(3376-3378)GTC>GAC	p.V1126D	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1126	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCAGTAAATGACTCTGAACCC	0.468													T	41514514	T	T	41514514	3	4	26	1	0	0	0	0	1	0	0	0	4768	275	10	5	2725	5	DSCAM	21	41514514	Missense_Mutation	SNP	A	TCGA-06-0155-01B-01D-1492-08		41514514	6615381	82	1727											
PRDM15	63977	broad.mit.edu	37	chr21	43230603	43230603	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgcgcctccaccttgtcGtgtgtgagctgaacgtgctt	11	13	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr21:43230603G>A	uc002yzq.1	-	28	3768	c.3657C>T	c.(3655-3657)CAC>CAT	p.H1219H	PRDM15_uc002yzo.2_Silent_p.H890H|PRDM15_uc002yzp.2_Silent_p.H910H|PRDM15_uc002yzr.1_Silent_p.H910H	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1219	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCACCTTGTCGTGTGTGAGCT	0.612													A	43230603	A	A	43230603	2	1	26	1	0	0	0	0	0	0	0	1	12456	1136	40	1		1	PRDM15	21	43230603	Silent	SNP	G	TCGA-06-0155-01B-01D-1492-08	1716089	43230603	4899292	83	1728											
IL2RB	3560	broad.mit.edu	37	chr22	37524874	37524874	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggacgatgaggggaagggCgaagagagccacttctggtg	18	6	1	2			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chr22:37524874C>T	uc003aqv.1	-	10	1049	c.918G>A	c.(916-918)TCG>TCA	p.S306S		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	306	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	AGGGGAAGGGCGAAGAGAGCC	0.607													T	37524874	T	T	37524874	2	4	26	1	0	0	0	0	0	0	0	1	7687	755	27	1		1	IL2RB	22	37524874	Silent	SNP	C	TCGA-06-0155-01B-01D-1492-08		37524874	13779692	84	1729											
KDM6A	7403	broad.mit.edu	37	chrX	44922695	44922695	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	aacaggagttgcacaggtacGatctactggaattcctaatg	10	8	1	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chrX:44922695G>C	uc004dge.3	+	16	1931	c.1556G>C	c.(1555-1557)CGA>CCA	p.R519P	KDM6A_uc010nhk.2_Missense_Mutation_p.R485P|KDM6A_uc011mkz.1_Missense_Mutation_p.R571P|KDM6A_uc011mla.1_Missense_Mutation_p.R474P|KDM6A_uc011mlb.1_Missense_Mutation_p.R526P|KDM6A_uc011mlc.1_Missense_Mutation_p.R223P|KDM6A_uc011mld.1_Missense_Mutation_p.R158P	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	519					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GCACAGGTACGATCTACTGGA	0.463			D|N|F|S		renal|oesophageal SCC|MM								C	44922695	C	C	44922695	3	2	26	1	0	0	0	0	1	0	0	0	8137	1058	37	5	1618	5	KDM6A	23	44922695	Missense_Mutation	SNP	G	TCGA-06-0155-01B-01D-1492-08		44922695	110347865	85	1730											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299171	125299171	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcctccacatccctcggaCggatgtgggcatatactggg	13	12	0	0			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chrX:125299171C>T	uc004euk.1	-	1	764	c.737G>A	c.(736-738)CGT>CAT	p.R246H		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	246										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						ATCCCTCGGACGGATGTGGGC	0.647													T	125299171	T	T	125299171	3	4	26	1	0	0	0	0	1	0	0	0	4265	536	19	1	658	1	DCAF12L2	23	125299171	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	80376476	125299171	29971389	86	1731											
SLITRK4	139065	broad.mit.edu	37	chrX	142718314	142718314	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagttgcaattcaacgacaCggccaatgtgttccagaacc	8	13	1	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chrX:142718314C>T	uc004fbx.2	-	2	987	c.611G>A	c.(610-612)CGT>CAT	p.R204H	SLITRK4_uc004fby.2_Missense_Mutation_p.R204H	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	204	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCAACGACACGGCCAATGTG	0.428													T	142718314	T	T	142718314	3	4	26	1	0	0	0	0	1	0	0	0	14745	536	19	1	1906	1	SLITRK4	23	142718314	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	17419143	142718314	12552246	87	1732											
SPANXN2	494119	broad.mit.edu	37	chrX	142795437	142795437	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgtcctcctcctcttggaCgggattgatggagttctctc	10	12	2	1			TCGA-06-0155-01B-01D-1492-08	TCGA-06-0155-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc59e9b-3a60-4178-9fa0-81cf5171622d	b28ec581-f388-4a90-8ec5-63d737a051b8	g.chrX:142795437C>T	uc004fbz.2	-	2	995	c.241G>A	c.(241-243)GTC>ATC	p.V81I		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	81										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTTGGACGGGATTGATG	0.453													T	142795437	T	T	142795437	3	4	26	1	0	0	0	0	1	0	0	0	14991	536	19	1	305	1	SPANXN2	23	142795437	Missense_Mutation	SNP	C	TCGA-06-0155-01B-01D-1492-08	77123	142795437	12475123	88	1733											
SPTA1	6708	broad.mit.edu	37	chr1	158585171	158585171	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggttagttgacgcttcatcGcctggatctccttctgtttt	9	10	3	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr1:158585171G>A	uc001fst.1	-	48	6822	c.6623C>T	c.(6622-6624)GCG>GTG	p.A2208V		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2208	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACGCTTCATCGCCTGGATCTC	0.468													A	158585171	A	A	158585171	3	1	27	1	0	0	0	0	1	0	0	0	15115	1087	38	1	656	1	SPTA1	1	158585171	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08		158585171	90665450	1	1734											
SERPINC1	462	broad.mit.edu	37	chr1	173878724	173878724	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttttcagggctgaacagatcGacaaggcccatgtcttgcag	11	10	2	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr1:173878724G>A	uc001gjt.2	-	5	1238	c.1119C>T	c.(1117-1119)GTC>GTT	p.V373V		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	373					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	TGAACAGATCGACAAGGCCCA	0.527													A	173878724	A	A	173878724	2	1	27	1	0	0	0	0	0	0	0	1	14109	1045	37	2		2	SERPINC1	1	173878724	Silent	SNP	G	TCGA-06-0157-01A-01D-1491-08	15293553	173878724	75371897	2	1735											
SYT2	127833	broad.mit.edu	37	chr1	202566072	202566072	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttgtcatagtccagcacgGtgaccactacctggactttc	9	13	1	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr1:202566072G>A	uc001gye.2	-	9	1266	c.1073C>T	c.(1072-1074)ACC>ATC	p.T358I	SYT2_uc010pqb.1_Missense_Mutation_p.T358I|SYT2_uc009xaf.2_Missense_Mutation_p.T188I	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	358	Phospholipid binding (By similarity).|C2 2.|Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	GTCCAGCACGGTGACCACTAC	0.547													A	202566072	A	A	202566072	3	1	27	1	0	0	0	0	1	0	0	0	15471	1261	44	3	190	3	SYT2	1	202566072	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	28687348	202566072	46684549	3	1736											
HSD11B1	3290	broad.mit.edu	37	chr1	209907741	209907741	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatcaaagggggagctctgCgccaagaagaagtgtattat	12	7	3	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr1:209907741C>T	uc001hhj.2	+	7	861	c.754C>T	c.(754-756)CGC>TGC	p.R252C	HSD11B1_uc001hhk.2_Missense_Mutation_p.R252C	NM_181755	NP_861420	P28845	DHI1_HUMAN	11-beta-hydroxysteroid dehydrogenase 1	252	Lumenal (Potential).				glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase (NADP+) activity|11-beta-hydroxysteroid dehydrogenase|binding			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	GGGAGCTCTGCGCCAAGAAGA	0.463													T	209907741	T	T	209907741	3	4	27	1	0	0	0	0	1	0	0	0	7375	768	27	1	776	1	HSD11B1	1	209907741	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	7341669	209907741	39342880	4	1737											
RYR2	6262	broad.mit.edu	37	chr1	237777626	237777626	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtccccatgacggaggagaCgaagagcatcaccctgttcc	11	13	1	3			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr1:237777626C>T	uc001hyl.1	+	37	5318	c.5198C>T	c.(5197-5199)ACG>ATG	p.T1733M		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1733	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACGGAGGAGACGAAGAGCATC	0.557													T	237777626	T	T	237777626	3	4	27	1	0	0	0	0	1	0	0	0	13769	536	19	1	5344	1	RYR2	1	237777626	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	27869885	237777626	11472995	5	1738											
C2orf16	84226	broad.mit.edu	37	chr2	27803330	27803330	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagagaatcaccaagcgactTagaaaacacagaaagttcta	7	8	2	3			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr2:27803330T>C	uc002rkz.3	+	1	3942	c.3891T>C	c.(3889-3891)CTT>CTC	p.L1297L	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1297										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CCAAGCGACTTAGAAAACACA	0.403													C	27803330	C	C	27803330	2	2	27	1	0	0	0	0	0	0	0	1	2157	1741	61	4		4	C2orf16	2	27803330	Silent	SNP	T	TCGA-06-0157-01A-01D-1491-08		27803330	215396043	6	1739											
SNRNP200	23020	broad.mit.edu	37	chr2	96964138	96964138	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcttcactttgtgcactggCcagcaaggtacagtataaaa	9	9	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr2:96964138C>T	uc002svu.2	-	9	1089	c.1003G>A	c.(1003-1005)GCC>ACC	p.A335T		NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	335						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						TGTGCACTGGCCAGCAAGGTA	0.433													T	96964138	T	T	96964138	3	4	27	1	0	0	0	0	1	0	0	0	14852	739	26	3	5555	3	SNRNP200	2	96964138	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	69160808	96964138	146235235	7	1740											
TBR1	10716	broad.mit.edu	37	chr2	162280004	162280004	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggaccagttcgtgagcAactacgccaaggcccgcttc	11	14	0	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr2:162280004A>G	uc002ubw.1	+	6	1617	c.1315A>G	c.(1315-1317)AAC>GAC	p.N439D	TBR1_uc010foy.2_Missense_Mutation_p.N152D	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	439						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GTTCGTGAGCAACTACGCCAA	0.597													G	162280004	G	G	162280004	3	3	27	1	0	0	0	0	1	0	0	0	15644	130	5	4	1337	4	TBR1	2	162280004	Missense_Mutation	SNP	A	TCGA-06-0157-01A-01D-1491-08	65315866	162280004	80919369	8	1741											
TTN	7273	broad.mit.edu	37	chr2	179542633	179542633	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaactggaactggttcacGtttctttggcactttaaaga	10	7	2	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr2:179542633G>A	uc010zfg.1	-	143	30498	c.30274C>T	c.(30274-30276)CGT>TGT	p.R10092C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R6753C|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11019							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTGGTTCACGTTTCTTTGGC	0.363													A	179542633	A	A	179542633	3	1	27	1	0	0	0	0	1	0	0	0	16732	1145	40	1	70391	1	TTN	2	179542633	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	17262629	179542633	63656740	9	1742											
PDE1A	5136	broad.mit.edu	37	chr2	183053766	183053766	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtggggaaaatggaagccCtaattcagcttctttatctc	9	8	3	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr2:183053766C>T	uc002uos.2	-	12	1279	c.1195G>A	c.(1195-1197)GGG>AGG	p.G399R	PDE1A_uc010zfp.1_Missense_Mutation_p.G295R|PDE1A_uc002uoq.1_Missense_Mutation_p.G399R|PDE1A_uc010zfq.1_Missense_Mutation_p.G399R|PDE1A_uc002uor.2_Missense_Mutation_p.G383R|PDE1A_uc002uou.2_Missense_Mutation_p.G365R	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	399	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			AATGGAAGCCCTAATTCAGCT	0.413													T	183053766	T	T	183053766	3	4	27	1	0	0	0	0	1	0	0	0	11633	681	24	3	506	3	PDE1A	2	183053766	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	3511133	183053766	60145607	10	1743											
STXBP5L	9515	broad.mit.edu	37	chr3	121126274	121126274	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caagaaataggagatcatcaGtatacaataatctgctcaga	7	7	4	3			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr3:121126274G>C	uc003eec.3	+	24	2984	c.2844G>C	c.(2842-2844)CAG>CAC	p.Q948H	STXBP5L_uc011bji.1_Missense_Mutation_p.Q924H	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	948	WD 12.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GAGATCATCAGTATACAATAA	0.378													C	121126274	C	C	121126274	3	2	27	1	0	0	0	0	1	0	0	0	15356	1020	36	5	2934	5	STXBP5L	3	121126274	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08		121126274	76896156	11	1744											
DNAJB11	51726	broad.mit.edu	37	chr3	186302367	186302367	+	Frame_Shift_Del	DEL	A	-	-													aaaagaacagttaacagaggAagcgagagaaggtatggcat							TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr3:186302367delA	uc003fqi.2	+	9	1221	c.1001delA	c.(1000-1002)GAAfs	p.E334fs		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	334					protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		TTAACAGAGGAAGCGAGAGAA	0.303													-	186302367	-	-	186302367	7	5	27	1	0	1	0	1	0	0	0	0	4616	246	9	0	1035	0	DNAJB11	3	186302367	Frame_Shift_Del	DEL	A	TCGA-06-0157-01A-01D-1491-08	65176093	186302367	11720063	12	1745											
UGT2B4	7363	broad.mit.edu	37	chr4	70361103	70361103	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	attttaagtaactcggccagCagctcaccaaaggggaaaac	9	10	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr4:70361103C>G	uc003hek.3	-	1	524	c.477G>C	c.(475-477)CTG>CTC	p.L159L	UGT2B4_uc011cap.1_Silent_p.L23L|UGT2B4_uc003hel.3_Silent_p.L159L	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	159					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						ACTCGGCCAGCAGCTCACCAA	0.428													G	70361103	G	G	70361103	2	3	27	1	0	0	0	0	0	0	0	1	16958	697	25	5		5	UGT2B4	4	70361103	Silent	SNP	C	TCGA-06-0157-01A-01D-1491-08		70361103	120793173	13	1746											
IRX1	79192	broad.mit.edu	37	chr5	3601124	3601124	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccccgcaggagggaacgccGcggatcctagcagccctccc	13	18	0	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr5:3601124G>A	uc003jde.2	+	4	1465	c.1413G>A	c.(1411-1413)CCG>CCA	p.P471P		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	471						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						AGGGAACGCCGCGGATCCTAG	0.652													A	3601124	A	A	3601124	2	1	27	1	0	0	0	0	0	0	0	1	7843	1074	38	1		1	IRX1	5	3601124	Silent	SNP	G	TCGA-06-0157-01A-01D-1491-08		3601124	177314136	14	1747											
TARS	6897	broad.mit.edu	37	chr5	33461376	33461376	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gaaaaattccttggagatatCgaagtatgggatcaagctga	11	5	1	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr5:33461376C>G	uc003jhy.2	+	13	1822	c.1527C>G	c.(1525-1527)ATC>ATG	p.I509M	TARS_uc011cob.1_Missense_Mutation_p.I497M|TARS_uc010iup.1_Missense_Mutation_p.I450M|TARS_uc011coc.1_Missense_Mutation_p.I530M|TARS_uc003jhz.2_Missense_Mutation_p.I405M|TARS_uc011cod.1_Missense_Mutation_p.I388M	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	509					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	TTGGAGATATCGAAGTATGGG	0.373													G	33461376	G	G	33461376	3	3	27	1	0	0	0	0	1	0	0	0	15556	874	31	5	1577	5	TARS	5	33461376	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	29860252	33461376	147453884	15	1748											
RPS12	6206	broad.mit.edu	37	chr6	133137703	133137703	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	accaaatcaacctaattaagGtaaggctgctaaggattgtg	9	7	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr6:133137703G>T	uc003qdx.2	+	4	316	c.234_splice	c.e4+1	p.K78_splice	RPS12_uc003qdy.1_3'UTR	NM_001016	NP_001007	P25398	RS12_HUMAN	ribosomal protein S12						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	structural constituent of ribosome				0	Breast(56;0.214)			OV - Ovarian serous cystadenocarcinoma(155;0.00284)|GBM - Glioblastoma multiforme(226;0.0256)		CCTAATTAAGGTAAGGCTGCT	0.438													T	133137703	T	T	133137703	5	4	27	1	0	0	0	0	0	0	1	0	13622	1275	44	5	245	5	RPS12	6	133137703	Splice_Site	SNP	G	TCGA-06-0157-01A-01D-1491-08		133137703	37977364	16	1749											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	27	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08		55221822	103916841	17	1750											
PCLO	27445	broad.mit.edu	37	chr7	82784773	82784773	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggagtctttccaactccaGgaggctgagctaaagccttt	10	11	1	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr7:82784773G>A	uc003uhx.2	-	2	1473	c.1184C>T	c.(1183-1185)CCT>CTT	p.P395L	PCLO_uc003uhv.2_Missense_Mutation_p.P395L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	346	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCCAACTCCAGGAGGCTGAGC	0.592													A	82784773	A	A	82784773	3	1	27	1	0	0	0	0	1	0	0	0	11583	1000	35	3	14357	3	PCLO	7	82784773	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	27562951	82784773	76353890	18	1751											
GATA4	2626	broad.mit.edu	37	chr8	11607632	11607632	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttgcagtccgcctcccgcCgagtgggcctctcctgtgcc	11	18	2	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr8:11607632C>T	uc003wuc.2	+	4	1350	c.796C>T	c.(796-798)CGA>TGA	p.R266*	GATA4_uc003wub.1_Nonsense_Mutation_p.R60*|GATA4_uc011kxc.1_Nonsense_Mutation_p.R267*	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	266					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		CGCCTCCCGCCGAGTGGGCCT	0.632													T	11607632	T	T	11607632	4	4	27	1	0	0	0	0	0	1	0	0	6256	644	23	2	806	2	GATA4	8	11607632	Nonsense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08		11607632	134756390	19	1752											
SLC18A1	6570	broad.mit.edu	37	chr8	20022464	20022464	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggccacccccatgttggcaaAgcagatggaccctggggaga	14	12	0	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr8:20022464A>T	uc011kyq.1	-	11	1402	c.931T>A	c.(931-933)TTT>ATT	p.F311I	SLC18A1_uc003wzl.2_Missense_Mutation_p.F98I|SLC18A1_uc003wzm.2_Missense_Mutation_p.F311I|SLC18A1_uc011kyr.1_Missense_Mutation_p.F311I|SLC18A1_uc003wzn.2_Intron|SLC18A1_uc010ltf.2_RNA|SLC18A1_uc003wzo.2_Intron	NM_001135691	NP_001129163	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine),	311	Helical; (Potential).				neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			ovary(2)	2				Colorectal(74;0.0747)		ATGTTGGCAAAGCAGATGGAC	0.612													T	20022464	T	T	20022464	3	4	27	1	0	0	0	0	1	0	0	0	14425	72	3	5	674	5	SLC18A1	8	20022464	Missense_Mutation	SNP	A	TCGA-06-0157-01A-01D-1491-08	8414832	20022464	126341558	20	1753											
MRPL13	28998	broad.mit.edu	37	chr8	121432169	121432170	+	Frame_Shift_Ins	INS	-	T	T													agcatgccataaatagctagINSttttacaatctgaaagatat							TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr8:121432169_121432170insT	uc003ypa.2	-	5	628_629	c.315_316insA	c.(313-318)AAACTAfs	p.K105fs	MRPL13_uc010mdf.2_RNA	NM_014078	NP_054797	Q9BYD1	RM13_HUMAN	mitochondrial ribosomal protein L13	105_106					translation	mitochondrial large ribosomal subunit	protein binding|structural constituent of ribosome			central_nervous_system(1)	1	Lung NSC(37;1.69e-07)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			TAAATAGCTAGTTTTACAATCT	0.356													T	121432170	T	T	121432169	7	5	27	1	0	1	1	0	0	0	0	0	9778	1020	36	0	232	0	MRPL13	8	121432169	Frame_Shift_Ins	INS	-	TCGA-06-0157-01A-01D-1491-08	101409705	121432169	24931853	21	1754											
AQP7	364	broad.mit.edu	37	chr9	33385701	33385701	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaagatgcgggggggcaggTcccgggacgggttgatggca	21	7	0	3			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr9:33385701T>C	uc003zst.2	-	7	861	c.689A>G	c.(688-690)GAC>GGC	p.D230G	SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Missense_Mutation_p.D173G|AQP7_uc010mjs.2_Missense_Mutation_p.D138G|AQP7_uc010mjt.2_Missense_Mutation_p.D138G|AQP7_uc011lnx.1_Missense_Mutation_p.D230G|AQP7_uc011lny.1_Missense_Mutation_p.D229G|AQP7_uc003zss.3_Missense_Mutation_p.D138G|AQP7_uc011lnz.1_Missense_Mutation_p.D138G|AQP7_uc011loa.1_Silent_p.G98G	NM_001170	NP_001161	O14520	AQP7_HUMAN	aquaporin 7	230	Extracellular (Potential).				excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		GGGGGGCAGGTCCCGGGACGG	0.587													C	33385701	C	C	33385701	3	2	27	1	0	0	0	0	1	0	0	0	831	1667	58	4	347	4	AQP7	9	33385701	Missense_Mutation	SNP	T	TCGA-06-0157-01A-01D-1491-08		33385701	107827730	22	1755											
PTEN	5728	broad.mit.edu	37	chr10	89690819	89690820	+	Frame_Shift_Del	DEL	TA	-	-													ttagttgtgctgaaagacatTatgacaccgccaaatttaat							TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr10:89690819_89690820delTA	uc001kfb.2	+	5	1257_1258	c.226_227delTA	c.(226-228)TATfs	p.Y76fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	76	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.Y76fs*1(12)|p.L70fs*7(4)|p.R55fs*1(4)|p.?(2)|p.C71fs*6(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.Y76Y(1)|p.Y76*(1)|p.Y76del(1)|p.H75_T78del(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGAAAGACATTATGACACCGCC	0.272		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89690820	-	-	89690819	7	5	27	1	0	1	0	1	0	0	0	0	12738	1754	61	0	240	0	PTEN	10	89690819	Frame_Shift_Del	DEL	TA	TCGA-06-0157-01A-01D-1491-08		89690819	45843928	23	1756											
HSPA12A	259217	broad.mit.edu	37	chr10	118439024	118439024	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccaactcacttgcttttccGcaaggcgtgctccacactgt	7	16	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr10:118439024G>A	uc001lct.2	-	10	1381	c.1276C>T	c.(1276-1278)CGG>TGG	p.R426W	HSPA12A_uc001lcu.2_Missense_Mutation_p.R343W	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	426							ATP binding			ovary(1)	1				all cancers(201;0.0158)		TTGCTTTTCCGCAAGGCGTGC	0.547													A	118439024	A	A	118439024	3	1	27	1	0	0	0	0	1	0	0	0	7404	1086	38	1	763	1	HSPA12A	10	118439024	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	28748205	118439024	17095723	24	1757											
JAKMIP3	282973	broad.mit.edu	37	chr10	133949482	133949482	+	Frame_Shift_Del	DEL	A	-	-													agtacaagcctctgctggatAaaaacaagcgcctcagtcgg							TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr10:133949482delA	uc001lkx.3	+	5	1018	c.1018delA	c.(1018-1020)AAAfs	p.K340fs		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TCTGCTGGATAAAAACAAGCG	0.443													-	133949482	-	-	133949482	7	5	27	1	0	1	0	1	0	0	0	0	7942	363	13	0	1036	0	JAKMIP3	10	133949482	Frame_Shift_Del	DEL	A	TCGA-06-0157-01A-01D-1491-08	15510458	133949482	1585265	25	1758											
KCNQ1	3784	broad.mit.edu	37	chr11	2466624	2466624	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catctacagcacgcgccgccCggtgttggcgcgcacccacg	12	18	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr11:2466624C>T	uc001lwn.2	+	1	404	c.296C>T	c.(295-297)CCG>CTG	p.P99L	KCNQ1_uc009ydo.1_Missense_Mutation_p.P99L	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	99				TRRPVLARTHV -> METRGSRLTGG (in Ref. 6; AAC51781).	blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	ACGCGCCGCCCGGTGTTGGCG	0.582													T	2466624	T	T	2466624	3	4	27	1	0	0	0	0	1	0	0	0	8082	652	23	2	298	2	KCNQ1	11	2466624	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08		2466624	132539892	26	1759											
OR5M8	219484	broad.mit.edu	37	chr11	56258561	56258561	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaggtaacactgcacaagacAggcaggataggaaatgcttt	11	7	0	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr11:56258561A>G	uc001nix.1	-	1	286	c.286T>C	c.(286-288)TGT>CGT	p.C96R		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					TGCACAAGACAGGCAGGATAG	0.473													G	56258561	G	G	56258561	3	3	27	1	0	0	0	0	1	0	0	0	11176	188	7	4	653	4	OR5M8	11	56258561	Missense_Mutation	SNP	A	TCGA-06-0157-01A-01D-1491-08	53791937	56258561	78747955	27	1760											
VWF	7450	broad.mit.edu	37	chr12	6122757	6122757	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgggcctgccaagatcCgtagctgggctgcatcgtag	14	12	0	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr12:6122757C>T	uc001qnn.1	-	32	5760	c.5510G>A	c.(5509-5511)CGG>CAG	p.R1837Q	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1837	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	TGCCAAGATCCGTAGCTGGGC	0.532													T	6122757	T	T	6122757	3	4	27	1	0	0	0	0	1	0	0	0	17243	652	23	2	3015	2	VWF	12	6122757	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08		6122757	127729138	28	1761											
TAS2R13	50838	broad.mit.edu	37	chr12	11061487	11061487	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttaaaaataagaagaccaaGgttcctagcagtatcatcag	7	7	2	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr12:11061487G>A	uc001qzg.1	-	1	675	c.411C>T	c.(409-411)ACC>ACT	p.T137T	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron	NM_023920	NP_076409	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	137	Helical; Name=4; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|skin(1)	2						AGAAGACCAAGGTTCCTAGCA	0.353													A	11061487	A	A	11061487	2	1	27	1	0	0	0	0	0	0	0	1	15564	987	35	3		3	TAS2R13	12	11061487	Silent	SNP	G	TCGA-06-0157-01A-01D-1491-08	4938730	11061487	122790408	29	1762											
TRPV4	59341	broad.mit.edu	37	chr12	110236432	110236432	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactcaccccaatcttgcccGtcttggcagccatcatgagg	8	16	4	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr12:110236432G>A	uc001tpj.1	-	5	1234	c.1139C>T	c.(1138-1140)ACG>ATG	p.T380M	TRPV4_uc001tpg.1_Missense_Mutation_p.T346M|TRPV4_uc001tph.1_Missense_Mutation_p.T333M|TRPV4_uc001tpi.1_Missense_Mutation_p.T333M|TRPV4_uc001tpk.1_Missense_Mutation_p.T380M|TRPV4_uc001tpl.1_Missense_Mutation_p.T380M	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	380	Cytoplasmic (Potential).|ANK 3.				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AATCTTGCCCGTCTTGGCAGC	0.612													A	110236432	A	A	110236432	3	1	27	1	0	0	0	0	1	0	0	0	16595	1145	40	1	1520	1	TRPV4	12	110236432	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	99174945	110236432	23615463	30	1763											
HPD	3242	broad.mit.edu	37	chr12	122292681	122292681	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctcccgcatgattttggcGccccgttcccgtgctttctg	11	15	1	1	rs61742674	byFrequency	TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr12:122292681G>A	uc001ubj.2	-	7	382	c.342C>T	c.(340-342)GGC>GGT	p.G114G	HPD_uc001ubk.2_Silent_p.G75G	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	114					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	TGATTTTGGCGCCCCGTTCCC	0.597													A	122292681	A	A	122292681	2	1	27	1	0	0	0	0	0	0	0	1	7332	1074	38	1		1	HPD	12	122292681	Silent	SNP	G	TCGA-06-0157-01A-01D-1491-08	12056249	122292681	11559214	31	1764											
COL4A1	1282	broad.mit.edu	37	chr13	110895031	110895031	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcaactcaccttttgtccCttcactccatggcagtcaca	6	16	3	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr13:110895031C>T	uc001vqw.3	-	2	257	c.135G>A	c.(133-135)AAG>AAA	p.K45K	COL4A1_uc010agl.2_Silent_p.K45K	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	45					angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTTTTGTCCCTTCACTCCAT	0.408													T	110895031	T	T	110895031	2	4	27	1	0	0	0	0	0	0	0	1	3689	680	24	3		3	COL4A1	13	110895031	Silent	SNP	C	TCGA-06-0157-01A-01D-1491-08		110895031	4274847	32	1765											
KCNH5	27133	broad.mit.edu	37	chr14	63316465	63316465	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttgggacctgatagagttttAggaagtcccgtacattattc	10	7	0	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr14:63316465A>T	uc001xfx.2	-	8	1526	c.1475T>A	c.(1474-1476)CTA>CAA	p.L492Q	KCNH5_uc001xfy.2_Missense_Mutation_p.L492Q|KCNH5_uc001xfz.1_Missense_Mutation_p.L434Q	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	492	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ATAGAGTTTTAGGAAGTCCCG	0.393													T	63316465	T	T	63316465	3	4	27	1	0	0	0	0	1	0	0	0	8035	420	15	5	1541	5	KCNH5	14	63316465	Missense_Mutation	SNP	A	TCGA-06-0157-01A-01D-1491-08		63316465	44033075	33	1766											
IGF1R	3480	broad.mit.edu	37	chr15	99250943	99250943	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ccaagctcacggtcattaccGagtacttgctgctgttccga	9	13	2	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr15:99250943G>T	uc002bul.2	+	2	297	c.247G>T	c.(247-249)GAG>TAG	p.E83*	IGF1R_uc010urq.1_Nonsense_Mutation_p.E83*|IGF1R_uc010bon.2_Nonsense_Mutation_p.E83*	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	83					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GGTCATTACCGAGTACTTGCT	0.597													T	99250943	T	T	99250943	4	4	27	1	0	0	0	0	0	1	0	0	7571	1059	37	5	253	5	IGF1R	15	99250943	Nonsense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08		99250943	3280449	34	1767											
WDR90	197335	broad.mit.edu	37	chr16	701986	701986	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggctgctgccggcacccacGtgttgactcacgagtcggct	13	15	1	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr16:701986G>A	uc002cii.1	+	9	1054	c.1000G>A	c.(1000-1002)GTG>ATG	p.V334M	WDR90_uc002cig.1_Missense_Mutation_p.V334M|WDR90_uc002cih.1_Missense_Mutation_p.V335M|WDR90_uc002cij.1_RNA	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	334										ovary(1)	1		Hepatocellular(780;0.0218)				CGGCACCCACGTGTTGACTCA	0.687													A	701986	A	A	701986	3	1	27	1	0	0	0	0	1	0	0	0	17334	1145	40	1	1034	1	WDR90	16	701986	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08		701986	89652767	35	1768											
RHBDL1	9028	broad.mit.edu	37	chr16	727080	727080	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaccccgggcaccgtgcccGcgcctggcgcttcctcacct	10	22	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr16:727080G>A	uc002cis.1	+	3	758	c.731G>A	c.(730-732)CGC>CAC	p.R244H	RHBDL1_uc002cir.1_Missense_Mutation_p.R179H|RHBDL1_uc010uun.1_Missense_Mutation_p.R179H	NM_003961	NP_003952	O75783	RHBL1_HUMAN	rhomboid protease 1	244					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)				CACCGTGCCCGCGCCTGGCGC	0.617													A	727080	A	A	727080	3	1	27	1	0	0	0	0	1	0	0	0	13321	1087	38	1	741	1	RHBDL1	16	727080	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	25094	727080	89627673	36	1769											
SLC12A4	6560	broad.mit.edu	37	chr16	67984224	67984224	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtgcagaggggctcacccGgaggaaggggatgatgttgt	19	6	1	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr16:67984224G>A	uc002euz.2	-	12	1768	c.1627C>T	c.(1627-1629)CGG>TGG	p.R543W	SLC12A4_uc010ceu.2_Missense_Mutation_p.R537W|SLC12A4_uc010vkh.1_Missense_Mutation_p.R512W|SLC12A4_uc010vki.1_Missense_Mutation_p.R543W|SLC12A4_uc010vkj.1_Missense_Mutation_p.R545W|SLC12A4_uc002eva.2_Missense_Mutation_p.R543W|SLC12A4_uc010cev.1_5'Flank|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	543					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GGGCTCACCCGGAGGAAGGGG	0.642													A	67984224	A	A	67984224	3	1	27	1	0	0	0	0	1	0	0	0	14385	1115	39	2	1682	2	SLC12A4	16	67984224	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	67257144	67984224	22370529	37	1770											
CDH15	1013	broad.mit.edu	37	chr16	89261311	89261311	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccccagtgtgccgccttaCgacacagccctcatctatga	8	16	2	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr16:89261311C>T	uc002fmt.2	+	14	2270	c.2193C>T	c.(2191-2193)TAC>TAT	p.Y731Y		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	731	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		TGCCGCCTTACGACACAGCCC	0.637													T	89261311	T	T	89261311	2	4	27	1	0	0	0	0	0	0	0	1	3100	547	19	1		1	CDH15	16	89261311	Silent	SNP	C	TCGA-06-0157-01A-01D-1491-08	21277087	89261311	1093442	38	1771											
DNAH9	1770	broad.mit.edu	37	chr17	11648135	11648135	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcactacgactggggcctaCgggccatcaagtccgtgctg	12	13	2	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr17:11648135C>T	uc002gne.2	+	31	6201	c.6133C>T	c.(6133-6135)CGG>TGG	p.R2045W	DNAH9_uc010coo.2_Missense_Mutation_p.R1339W	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2045	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGGGGCCTACGGGCCATCAA	0.557													T	11648135	T	T	11648135	3	4	27	1	0	0	0	0	1	0	0	0	4608	527	19	1	6255	1	DNAH9	17	11648135	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08		11648135	69547075	39	1772											
SNX11	29916	broad.mit.edu	37	chr17	46198838	46198838	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcatgctgtgcctttggacCctggtcagttagaaacagtt	10	9	2	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr17:46198838C>A	uc002inf.1	+	8	1135	c.781C>A	c.(781-783)CCT>ACT	p.P261T	SNX11_uc010wlg.1_Missense_Mutation_p.P253T|SNX11_uc010wlh.1_Missense_Mutation_p.P253T|SNX11_uc010wli.1_Missense_Mutation_p.P200T|SNX11_uc010wlj.1_Missense_Mutation_p.P117T|SNX11_uc002ing.1_Missense_Mutation_p.P261T|SNX11_uc002inh.1_Missense_Mutation_p.P261T	NM_152244	NP_689450	Q9Y5W9	SNX11_HUMAN	sorting nexin 11	261					cell communication|protein transport	membrane	phosphatidylinositol binding				0						GCCTTTGGACCCTGGTCAGTT	0.522													A	46198838	A	A	46198838	3	1	27	1	0	0	0	0	1	0	0	0	14882	623	22	5	803	5	SNX11	17	46198838	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	34550703	46198838	34996372	40	1773											
TNRC6C	57690	broad.mit.edu	37	chr17	76089149	76089149	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttccccatagctggtcacGtgccaaatctgacagtgata	9	11	2	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr17:76089149G>A	uc002jud.2	+	16	4706	c.4106G>A	c.(4105-4107)CGT>CAT	p.R1369H	TNRC6C_uc002juf.2_Missense_Mutation_p.R1366H	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1369					gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGCTGGTCACGTGCCAAATCT	0.502													A	76089149	A	A	76089149	3	1	27	1	0	0	0	0	1	0	0	0	16339	1145	40	1	4156	1	TNRC6C	17	76089149	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	29890311	76089149	5106061	41	1774											
UTS2R	2837	broad.mit.edu	37	chr17	80332216	80332216	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagagatggcgctgacccccGagtccccgagcagcttccct	11	17	0	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr17:80332216G>A	uc010wvl.1	+	1	16	c.16G>A	c.(16-18)GAG>AAG	p.E6K		NM_018949	NP_061822	Q9UKP6	UR2R_HUMAN	urotensin 2 receptor	6	Extracellular (Potential).					integral to membrane|plasma membrane				breast(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			GCTGACCCCCGAGTCCCCGAG	0.721													A	80332216	A	A	80332216	3	1	27	1	0	0	0	0	1	0	0	0	17103	1059	37	2	18	2	UTS2R	17	80332216	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	4243067	80332216	862994	42	1775											
LAMA1	284217	broad.mit.edu	37	chr18	7023335	7023335	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacagggaacacaagattcGccaggcactgttgggtttcc	11	11	1	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr18:7023335G>A	uc002knm.2	-	19	2623	c.2529C>T	c.(2527-2529)GGC>GGT	p.G843G	LAMA1_uc010wzj.1_Silent_p.G319G	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	843	Laminin EGF-like 7.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACAAGATTCGCCAGGCACTG	0.527													A	7023335	A	A	7023335	2	1	27	1	0	0	0	0	0	0	0	1	8605	1074	38	1		1	LAMA1	18	7023335	Silent	SNP	G	TCGA-06-0157-01A-01D-1491-08		7023335	71053913	43	1776											
MUC16	94025	broad.mit.edu	37	chr19	9063659	9063659	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gttgagtgtgtcattgtcaaAgaggttgtgcttgacgtgtc	14	5	2	3			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr19:9063659A>T	uc002mkp.2	-	3	23991	c.23787T>A	c.(23785-23787)TCT>TCA	p.S7929S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7931	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCATTGTCAAAGAGGTTGTGC	0.458													T	9063659	T	T	9063659	2	4	27	1	0	0	0	0	0	0	0	1	9973	59	3	5		5	MUC16	19	9063659	Silent	SNP	A	TCGA-06-0157-01A-01D-1491-08		9063659	50065324	44	1777											
FFAR1	2864	broad.mit.edu	37	chr19	35842837	35842837	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctattcctggggggtgtgcgCggccatctgggccctcgtcc	15	14	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr19:35842837C>T	uc002nzc.2	+	1	393	c.383C>T	c.(382-384)GCG>GTG	p.A128V		NM_005303	NP_005294	O14842	FFAR1_HUMAN	free fatty acid receptor 1	128	Helical; Name=4; (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GGGGTGTGCGCGGCCATCTGG	0.667													T	35842837	T	T	35842837	3	4	27	1	0	0	0	0	1	0	0	0	5827	768	27	1	385	1	FFAR1	19	35842837	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	26779178	35842837	23286146	45	1778											
ZFP82	284406	broad.mit.edu	37	chr19	36884449	36884449	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagagtaagttgtcctcgtaCcctaaaagccttcccacatt	6	13	0	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr19:36884449C>T	uc002ody.1	-	5	1028	c.793G>A	c.(793-795)GTA>ATA	p.V265I		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	265	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						TGTCCTCGTACCCTAAAAGCC	0.433													T	36884449	T	T	36884449	3	4	27	1	0	0	0	0	1	0	0	0	17650	507	18	3	809	3	ZFP82	19	36884449	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	1041612	36884449	22244534	46	1779											
MEIS3	56917	broad.mit.edu	37	chr19	47910342	47910342	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttccccctgtacctgtgcGgttggattgatcgatcatag	10	12	1	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr19:47910342G>A	uc002pgu.2	-	10	1435	c.988C>T	c.(988-990)CGC>TGC	p.R330C	MEIS3_uc010xyp.1_RNA|MEIS3_uc002pgo.2_Missense_Mutation_p.R129C|MEIS3_uc002pgp.2_Missense_Mutation_p.R162C|MEIS3_uc002pgq.2_Missense_Mutation_p.R411C|MEIS3_uc002pgr.2_Missense_Mutation_p.R198C|MEIS3_uc002pgt.2_Missense_Mutation_p.R313C|MEIS3_uc002pgv.2_Missense_Mutation_p.R359C|MEIS3_uc002pgs.2_Missense_Mutation_p.R376C|MEIS3_uc010eld.2_Missense_Mutation_p.R376C	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	330						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		GTACCTGTGCGGTTGGATTGA	0.612													A	47910342	A	A	47910342	3	1	27	1	0	0	0	0	1	0	0	0	9469	1116	39	2	151	2	MEIS3	19	47910342	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	11025893	47910342	11218641	47	1780											
SIGLEC5	8778	broad.mit.edu	37	chr19	52129355	52129355	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccagctgcttgcttcctgCgggctttcactctaaggaaa	9	13	2	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr19:52129355C>T	uc002pxe.2	-	8	1533	c.1394G>A	c.(1393-1395)CGC>CAC	p.R465H		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	465	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TTGCTTCCTGCGGGCTTTCAC	0.527													T	52129355	T	T	52129355	3	4	27	1	0	0	0	0	1	0	0	0	14311	768	27	1	269	1	SIGLEC5	19	52129355	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	4219013	52129355	6999628	48	1781											
ZNF419	79744	broad.mit.edu	37	chr19	58004984	58004984	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaatgtggaaaattctatagCcacaagtccaaccttatcaa	6	9	2	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr19:58004984C>T	uc002qov.2	+	5	1299	c.1059C>T	c.(1057-1059)AGC>AGT	p.S353S	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Silent_p.S354S|ZNF419_uc010etz.1_Silent_p.S341S|ZNF419_uc010eua.1_Silent_p.S340S|ZNF419_uc002qow.2_Silent_p.S321S|ZNF419_uc010eub.1_Silent_p.S308S|ZNF419_uc010euc.1_Silent_p.S307S	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	353	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		AATTCTATAGCCACAAGTCCA	0.413													T	58004984	T	T	58004984	2	4	27	1	0	0	0	0	0	0	0	1	17893	738	26	3		3	ZNF419	19	58004984	Silent	SNP	C	TCGA-06-0157-01A-01D-1491-08	5875629	58004984	1123999	49	1782											
ZNF773	374928	broad.mit.edu	37	chr19	58018486	58018486	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaatgtggaaaattctatagCcacaagtccagccttatcaa	7	9	2	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr19:58018486C>T	uc002qox.2	+	4	1163	c.1023C>T	c.(1021-1023)AGC>AGT	p.S341S	ZNF547_uc002qpm.3_Intron|ZNF773_uc002qoy.2_Silent_p.S340S|ZNF773_uc002qoz.2_Intron	NM_198542	NP_940944	Q6PK81	ZN773_HUMAN	zinc finger protein 773	341	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		AATTCTATAGCCACAAGTCCA	0.418													T	58018486	T	T	58018486	2	4	27	1	0	0	0	0	0	0	0	1	18143	738	26	3		3	ZNF773	19	58018486	Silent	SNP	C	TCGA-06-0157-01A-01D-1491-08	13502	58018486	1110497	50	1783											
C20orf27	54976	broad.mit.edu	37	chr20	3735070	3735070	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcgggcctgcaccgtcacgCgcacacaggtgccagtgcca	13	17	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr20:3735070C>T	uc002wji.1	-	5	627	c.398G>A	c.(397-399)CGC>CAC	p.R133H	C20orf27_uc002wjf.1_3'UTR|C20orf27_uc002wjh.1_Missense_Mutation_p.R158H	NM_001039140	NP_001034229	Q9GZN8	CT027_HUMAN	hypothetical protein LOC54976	133											0						CACCGTCACGCGCACACAGGT	0.602													T	3735070	T	T	3735070	3	4	27	1	0	0	0	0	1	0	0	0	2107	768	27	1	134	1	C20orf27	20	3735070	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08		3735070	59290450	51	1784											
HAO1	54363	broad.mit.edu	37	chr20	7864254	7864254	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcactgtcagatcttggaaaCggccaaaggatttttcctca	9	10	3	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr20:7864254C>T	uc002wmw.1	-	8	1123	c.1099G>A	c.(1099-1101)GTT>ATT	p.V367I		NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	367					cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						ATCTTGGAAACGGCCAAAGGA	0.373													T	7864254	T	T	7864254	3	4	27	1	0	0	0	0	1	0	0	0	6951	536	19	1	17	1	HAO1	20	7864254	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	4129184	7864254	55161266	52	1785											
TMEM90B	79953	broad.mit.edu	37	chr20	24565630	24565630	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttctacttgtcccatgagGtaaggcctccttggtctgtc	9	13	2	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr20:24565630G>A	uc002wtw.1	+	3	1251	c.618_splice	c.e3+1	p.E206_splice		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B						response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						GTCCCATGAGGTAAGGCCTCC	0.627													A	24565630	A	A	24565630	5	1	27	1	0	0	0	0	0	0	1	0	16216	1275	44	3	625	3	TMEM90B	20	24565630	Splice_Site	SNP	G	TCGA-06-0157-01A-01D-1491-08	16701376	24565630	38459890	53	1786											
PTK6	5753	broad.mit.edu	37	chr20	62168644	62168644	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cccacatacttggggcccagGtgagcctggtcccgggacac	13	15	0	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr20:62168644G>T	uc002yfg.2	-	1	64	c.24C>A	c.(22-24)CAC>CAA	p.H8Q	PTK6_uc011aay.1_5'UTR|PTK6_uc011aba.1_Missense_Mutation_p.H8Q	NM_005975	NP_005966	Q13882	PTK6_HUMAN	PTK6 protein tyrosine kinase 6	8						cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|kidney(1)	2	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			TGGGGCCCAGGTGAGCCTGGT	0.716													T	62168644	T	T	62168644	3	4	27	1	0	0	0	0	1	0	0	0	12764	1252	44	5	1363	5	PTK6	20	62168644	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	37603014	62168644	856876	54	1787											
KRTAP13-2	337959	broad.mit.edu	37	chr21	31744289	31744289	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaaggaggttctggggcgGtagcaggaggtctggcaggg	21	6	2	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr21:31744289G>A	uc002ynz.3	-	1	269	c.243C>T	c.(241-243)TAC>TAT	p.Y81Y		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	81	4.|5 X 10 AA approximate repeats.					intermediate filament					0						TTCTGGGGCGGTAGCAGGAGG	0.602													A	31744289	A	A	31744289	2	1	27	1	0	0	0	0	0	0	0	1	8523	1256	44	3		3	KRTAP13-2	21	31744289	Silent	SNP	G	TCGA-06-0157-01A-01D-1491-08		31744289	16385606	55	1788											
KRTAP10-12	386685	broad.mit.edu	37	chr21	46117748	46117748	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acccgcccgccgcgtgcccgTcccctcctgctgtgtcccca	9	23	0	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chr21:46117748T>C	uc002zfw.1	+	1	662	c.632T>C	c.(631-633)GTC>GCC	p.V211A	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198699	NP_941972	P60413	KR10C_HUMAN	keratin associated protein 10-12	211	19 X 5 AA repeats of C-C-X(3).					keratin filament					0						CGCGTGCCCGTCCCCTCCTGC	0.726													C	46117748	C	C	46117748	3	2	27	1	0	0	0	0	1	0	0	0	8508	1667	58	4	634	4	KRTAP10-12	21	46117748	Missense_Mutation	SNP	T	TCGA-06-0157-01A-01D-1491-08	14373459	46117748	2012147	56	1789											
EGFL6	25975	broad.mit.edu	37	chrX	13637337	13637337	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attctggtccaaaggaaagcGctaacttccaaactggaaca	8	10	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chrX:13637337G>A	uc004cvi.2	+	9	1398	c.1158G>A	c.(1156-1158)GCG>GCA	p.A386A	EGFL6_uc004cvj.2_Silent_p.A386A|EGFL6_uc011mik.1_Silent_p.A287A	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	386					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						AAAGGAAAGCGCTAACTTCCA	0.388													A	13637337	A	A	13637337	2	1	27	1	0	0	0	0	0	0	0	1	4963	1074	38	1		1	EGFL6	23	13637337	Silent	SNP	G	TCGA-06-0157-01A-01D-1491-08		13637337	141633223	57	1790											
RPS6KA3	6197	broad.mit.edu	37	chrX	20193367	20193367	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caaaactaaacccccgaaaaAgctgatgtgcattagcacta	6	11	0	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chrX:20193367A>T	uc004czu.2	-	14	1142	c.1142T>A	c.(1141-1143)CTT>CAT	p.L381H	RPS6KA3_uc011mjk.1_Missense_Mutation_p.L352H|RPS6KA3_uc004czv.2_Missense_Mutation_p.L369H|RPS6KA3_uc011mjl.1_Missense_Mutation_p.L353H|RPS6KA3_uc011mjm.1_Missense_Mutation_p.L353H	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	381	AGC-kinase C-terminal.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity	p.L381H(1)		central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						CCCCCGAAAAAGCTGATGTGC	0.393													T	20193367	T	T	20193367	3	4	27	1	0	0	0	0	1	0	0	0	13652	72	3	5	1116	5	RPS6KA3	23	20193367	Missense_Mutation	SNP	A	TCGA-06-0157-01A-01D-1491-08	6556030	20193367	135077193	58	1791											
XK	7504	broad.mit.edu	37	chrX	37553630	37553630	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaggcaaatgccaaaaaatGgcctctcagaggagattgag	12	7	1	4			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chrX:37553630G>T	uc004ddq.2	+	2	419	c.337G>T	c.(337-339)GGC>TGC	p.G113C		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	113	Extracellular (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				GCCAAAAAATGGCCTCTCAGA	0.488													T	37553630	T	T	37553630	3	4	27	1	0	0	0	0	1	0	0	0	17428	1348	47	5	343	5	XK	23	37553630	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	17360263	37553630	117716930	59	1792											
SYP	6855	broad.mit.edu	37	chrX	49048172	49048172	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcctgtctccttaaacaCgaaccacaggttgccgaccc	7	17	1	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chrX:49048172C>T	uc004dmz.1	-	6	680	c.664G>A	c.(664-666)GTG>ATG	p.V222M	SYP_uc011mmz.1_Missense_Mutation_p.V104M|SYP_uc004dna.1_Missense_Mutation_p.V216M	NM_003179	NP_003170	P08247	SYPH_HUMAN	synaptophysin	222	Helical; (Potential).|MARVEL.				regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle maturation|synaptic vesicle membrane organization	cell junction|integral to synaptic vesicle membrane|synaptosome	calcium ion binding|cholesterol binding|transporter activity	p.V222M(1)		ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(315;0.00016)				TCCTTAAACACGAACCACAGG	0.682													T	49048172	T	T	49048172	3	4	27	1	0	0	0	0	1	0	0	0	15458	536	19	1	281	1	SYP	23	49048172	Missense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	11494542	49048172	106222388	60	1793											
AWAT1	158833	broad.mit.edu	37	chrX	69455983	69455983	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cacatcagggactatttcccCattacggtaagtatctcttc	6	12	2	0			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chrX:69455983C>A	uc004dxy.2	+	3	290	c.249C>A	c.(247-249)CCC>CCA	p.P83P		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	83					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			ovary(3)	3						ACTATTTCCCCATTACGGTAA	0.483													A	69455983	A	A	69455983	2	1	27	1	0	0	0	0	0	0	0	1	1234	581	21	5		5	AWAT1	23	69455983	Silent	SNP	C	TCGA-06-0157-01A-01D-1491-08	20407811	69455983	85814577	61	1794											
NONO	4841	broad.mit.edu	37	chrX	70516705	70516705	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaccttgcctatagggaaCgagagcagccacccagattt	11	11	0	2			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chrX:70516705C>T	uc004dzo.2	+	8	1461	c.751C>T	c.(751-753)CGA>TGA	p.R251*	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Nonsense_Mutation_p.R251*|NONO_uc004dzp.2_Nonsense_Mutation_p.R251*|NONO_uc011mpv.1_Nonsense_Mutation_p.R162*|NONO_uc004dzq.2_Nonsense_Mutation_p.R120*	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	251	DBHS.				DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					CTATAGGGAACGAGAGCAGCC	0.493			T	TFE3	papillary renal cancer								T	70516705	T	T	70516705	4	4	27	1	0	0	0	0	0	1	0	0	10534	528	19	1	769	1	NONO	23	70516705	Nonsense_Mutation	SNP	C	TCGA-06-0157-01A-01D-1491-08	1060722	70516705	84753855	62	1795											
GPR101	83550	broad.mit.edu	37	chrX	136113395	136113395	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atagaggagcaggtaaccgcGgcgctgggtcatcttggacg	16	9	2	1			TCGA-06-0157-01A-01D-1491-08	TCGA-06-0157-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b1e62d8e-24d2-4118-8cd0-3142acebdd5b	e3c99625-890c-48a0-8926-713cc7bfddf2	g.chrX:136113395G>A	uc011mwh.1	-	1	439	c.439C>T	c.(439-441)CGC>TGC	p.R147C		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	147	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					AGGTAACCGCGGCGCTGGGTC	0.597													A	136113395	A	A	136113395	3	1	27	1	0	0	0	0	1	0	0	0	6622	1116	39	2	1090	2	GPR101	23	136113395	Missense_Mutation	SNP	G	TCGA-06-0157-01A-01D-1491-08	65596690	136113395	19157165	63	1796											
TDRD10	126668	broad.mit.edu	37	chr1	154516937	154516937	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagggctccaccgttatgcgCgggactcgctgtctggcaga	15	12	1	1	rs151222618	byFrequency	TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr1:154516937C>T	uc009wow.2	+	10	1579	c.741C>T	c.(739-741)CGC>CGT	p.R247R	TDRD10_uc001ffd.2_Silent_p.R247R|TDRD10_uc001ffe.2_Silent_p.R168R	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	247	Tudor.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCGTTATGCGCGGGACTCGCT	0.632													T	154516937	T	T	154516937	2	4	28	1	0	0	0	0	0	0	0	1	15728	755	27	1		1	TDRD10	1	154516937	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08		154516937	94733684	1	1797											
LY9	4063	broad.mit.edu	37	chr1	160784327	160784327	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacagagaaggttgtctggtTgtttaacacatccatcatta	8	8	2	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr1:160784327T>G	uc001fwu.2	+	4	898	c.848T>G	c.(847-849)TTG>TGG	p.L283W	LY9_uc010pjs.1_Missense_Mutation_p.L283W|LY9_uc001fwv.2_Missense_Mutation_p.L283W|LY9_uc001fww.2_Missense_Mutation_p.L283W|LY9_uc001fwx.2_Missense_Mutation_p.L283W|LY9_uc001fwy.1_Missense_Mutation_p.L185W|LY9_uc001fwz.2_5'UTR	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	283	Extracellular (Potential).|Ig-like V-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GTTGTCTGGTTGTTTAACACA	0.547													G	160784327	G	G	160784327	3	3	28	1	0	0	0	0	1	0	0	0	9101	1821	63	5	994	5	LY9	1	160784327	Missense_Mutation	SNP	T	TCGA-06-0158-01A-01D-1491-08	6267390	160784327	88466294	2	1798											
CR2	1380	broad.mit.edu	37	chr1	207647215	207647215	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgtgtggagctagttaataCgtcctgccaagatgggtgag	14	7	0	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr1:207647215C>T	uc001hfw.2	+	11	2142	c.2048C>T	c.(2047-2049)ACG>ATG	p.T683M	CR2_uc001hfv.2_Missense_Mutation_p.T742M|CR2_uc009xch.2_Missense_Mutation_p.T683M	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	683	Sushi 11.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						CTAGTTAATACGTCCTGCCAA	0.438													T	207647215	T	T	207647215	3	4	28	1	0	0	0	0	1	0	0	0	3842	536	19	1	2271	1	CR2	1	207647215	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08	46862888	207647215	41603406	3	1799											
ACBD3	64746	broad.mit.edu	37	chr1	226347010	226347010	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atactgttgggctgcatactGctggaactgcacggcagtct	12	10	1	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr1:226347010G>C	uc001hpy.2	-	5	825	c.778C>G	c.(778-780)CAG>GAG	p.Q260E		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	260	Gln-rich.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		GCTGCATACTGCTGGAACTGC	0.448													C	226347010	C	C	226347010	3	2	28	1	0	0	0	0	1	0	0	0	123	1328	46	5	824	5	ACBD3	1	226347010	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	18699795	226347010	22903611	4	1800											
NUP133	55746	broad.mit.edu	37	chr1	229577744	229577744	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttccaagctgatccgcttgTagcaggtctttcacctccgg	9	14	2	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr1:229577744T>C	uc001htn.2	-	26	3470	c.3378A>G	c.(3376-3378)CTA>CTG	p.L1126L		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	1126					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				GATCCGCTTGTAGCAGGTCTT	0.343													C	229577744	C	C	229577744	2	2	28	1	0	0	0	0	0	0	0	1	10754	1625	57	4		4	NUP133	1	229577744	Silent	SNP	T	TCGA-06-0158-01A-01D-1491-08	3230734	229577744	19672877	5	1801											
OR13G1	441933	broad.mit.edu	37	chr1	247836129	247836129	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcatcttcggtatgatgcttGttgtgcagatgatgtccaca	11	8	1	3			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr1:247836129G>T	uc001idi.1	-	1	215	c.215C>A	c.(214-216)ACA>AAA	p.T72K		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TATGATGCTTGTTGTGCAGAT	0.443													T	247836129	T	T	247836129	3	4	28	1	0	0	0	0	1	0	0	0	10942	1377	48	5	712	5	OR13G1	1	247836129	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	18258385	247836129	1414492	6	1802											
OR2L8	391190	broad.mit.edu	37	chr1	248112665	248112665	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actccatattccttattgccGatccagggccatcaatcatt	5	13	2	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr1:248112665G>A	uc001idt.1	+	1	506	c.506G>A	c.(505-507)CGA>CAA	p.R169Q	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CCTTATTGCCGATCCAGGGCC	0.478													A	248112665	A	A	248112665	3	1	28	1	0	0	0	0	1	0	0	0	11009	1058	37	2	508	2	OR2L8	1	248112665	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	276536	248112665	1137956	7	1803											
SLC3A1	6519	broad.mit.edu	37	chr2	44527119	44527119	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcatctttaggaaattttaCggttctggctcacaaagggt	9	7	4	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr2:44527119C>T	uc002ruc.3	+	5	979	c.901C>T	c.(901-903)CGG>TGG	p.R301W	SLC3A1_uc002rty.2_Missense_Mutation_p.R301W|SLC3A1_uc002rtz.2_Missense_Mutation_p.R301W|SLC3A1_uc002rua.2_Missense_Mutation_p.R301W|SLC3A1_uc002rub.2_Missense_Mutation_p.R301W|SLC3A1_uc002rud.3_Missense_Mutation_p.R23W	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	301	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	GGAAATTTTACGGTTCTGGCT	0.363													T	44527119	T	T	44527119	3	4	28	1	0	0	0	0	1	0	0	0	14626	527	19	1	919	1	SLC3A1	2	44527119	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08		44527119	198672254	8	1804											
TSPYL6	388951	broad.mit.edu	37	chr2	54483145	54483145	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggaagccggggcggtgggaaCacgattggctccaagcggcc	18	11	0	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr2:54483145C>G	uc002rxr.2	-	1	265	c.144G>C	c.(142-144)GTG>GTC	p.V48V	ACYP2_uc002rxq.3_Intron	NM_001003937	NP_001003937	Q8N831	TSYL6_HUMAN	TSPY-like 6	48					nucleosome assembly	nucleus					0						GCGGTGGGAACACGATTGGCT	0.607													G	54483145	G	G	54483145	2	3	28	1	0	0	0	0	0	0	0	1	16660	465	17	5		5	TSPYL6	2	54483145	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08	9956026	54483145	188716228	9	1805											
C2orf62	375307	broad.mit.edu	37	chr2	219222293	219222293	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgctgttcttctctgagaCgctggccatggtctcagaca	11	11	3	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr2:219222293C>T	uc002vhr.2	+	3	184	c.155C>T	c.(154-156)ACG>ATG	p.T52M	C2orf62_uc002vhs.2_RNA	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	52											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTCTCTGAGACGCTGGCCATG	0.577													T	219222293	T	T	219222293	3	4	28	1	0	0	0	0	1	0	0	0	2181	536	19	1	165	1	C2orf62	2	219222293	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08	164739148	219222293	23977080	10	1806											
DES	1674	broad.mit.edu	37	chr2	220290674	220290674	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctcttcctccccaggtcGtcagtgaggccacacagcag	9	16	2	1	rs73991549	byFrequency	TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr2:220290674G>A	uc002vll.2	+	9	1461	c.1375G>A	c.(1375-1377)GTC>ATC	p.V459I		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	459	Tail.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton	p.V459I(1)		central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCCCCAGGTCGTCAGTGAGGC	0.607													A	220290674	A	A	220290674	3	1	28	1	0	0	0	0	1	0	0	0	4449	1145	40	1	1409	1	DES	2	220290674	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	1068381	220290674	22908699	11	1807											
KCNH8	131096	broad.mit.edu	37	chr3	19575121	19575121	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cccaagcacaactttgtagcAgtaatatcacctcagacatt	5	12	2	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr3:19575121A>T	uc003cbk.1	+	16	3049	c.2854A>T	c.(2854-2856)AGT>TGT	p.S952C	KCNH8_uc010hex.1_Missense_Mutation_p.S413C	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	952	Ser-rich.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						ACTTTGTAGCAGTAATATCAC	0.532													T	19575121	T	T	19575121	3	4	28	1	0	0	0	0	1	0	0	0	8038	188	7	5	2916	5	KCNH8	3	19575121	Missense_Mutation	SNP	A	TCGA-06-0158-01A-01D-1491-08		19575121	178447309	12	1808											
CCR8	1237	broad.mit.edu	37	chr3	39374303	39374303	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctggcagtatggctaaccGccattatggctaccatccca	9	14	0	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr3:39374303G>A	uc010hhr.2	+	2	619	c.481G>A	c.(481-483)GCC>ACC	p.A161T	CCR8_uc003cjm.2_Missense_Mutation_p.A78T	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	161	Helical; Name=4; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		ATGGCTAACCGCCATTATGGC	0.488													A	39374303	A	A	39374303	3	1	28	1	0	0	0	0	1	0	0	0	2947	1087	38	1	483	1	CCR8	3	39374303	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	19799182	39374303	158648127	13	1809											
MST1	4485	broad.mit.edu	37	chr3	49724141	49724144	+	Frame_Shift_Del	DEL	CTCG	-	-													gcgggggaggtcacagaactCtcgctcgatctgcggatccg							TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr3:49724141_49724144delCTCG	uc003cxg.2	-	7	892_895	c.820_823delCGAG	c.(820-825)CGAGAGfs	p.R274fs	MST1_uc011bcs.1_Frame_Shift_Del_p.S272fs|MST1_uc010hkx.2_Frame_Shift_Del_p.R195fs|MST1_uc011bct.1_Frame_Shift_Del_p.R274fs|MST1_uc011bcu.1_RNA|RNF123_uc003cxh.2_5'Flank	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	260_261	Kringle 2.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCACAGAACTCTCGCTCGATCTGC	0.662													-	49724144	-	-	49724141	7	5	28	1	0	1	0	1	0	0	0	0	9890	922	32	0	1402	0	MST1	3	49724141	Frame_Shift_Del	DEL	CTCG	TCGA-06-0158-01A-01D-1491-08	10349838	49724141	148298289	14	1810											
COL6A6	131873	broad.mit.edu	37	chr3	130284156	130284156	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtgcacggaatggcagtcGgaagaatcagggggtgcccc	16	9	1	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr3:130284156G>A	uc010htl.2	+	3	1011	c.980G>A	c.(979-981)CGG>CAG	p.R327Q		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	327	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AATGGCAGTCGGAAGAATCAG	0.532													A	130284156	A	A	130284156	3	1	28	1	0	0	0	0	1	0	0	0	3703	1116	39	2	990	2	COL6A6	3	130284156	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	80560015	130284156	67738274	15	1811											
AMBN	258	broad.mit.edu	37	chr4	71467259	71467259	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caccaaccaggccacagcacTgaaagaagcacttcagcctc	7	16	1	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr4:71467259T>A	uc003hfl.2	+	6	494	c.419T>A	c.(418-420)CTG>CAG	p.L140Q		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	140					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			GCCACAGCACTGAAAGAAGCA	0.557											OREG0016218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	71467259	A	A	71467259	3	1	28	1	0	0	0	0	1	0	0	0	563	1580	55	5	441	5	AMBN	4	71467259	Missense_Mutation	SNP	T	TCGA-06-0158-01A-01D-1491-08		71467259	119687017	16	1812											
ADAM29	11086	broad.mit.edu	37	chr4	175896768	175896768	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccccaatatcacagccctcCggatgtggtgattcctgtga	9	14	1	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr4:175896768C>T	uc003iuc.2	+	5	762	c.92C>T	c.(91-93)CCG>CTG	p.P31L	ADAM29_uc003iud.2_Missense_Mutation_p.P31L|ADAM29_uc010irr.2_Missense_Mutation_p.P31L|ADAM29_uc011cki.1_Missense_Mutation_p.P31L	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	31			P -> L (in a colorectal cancer sample; somatic mutation).		proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding	p.P31L(1)		skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CACAGCCCTCCGGATGTGGTG	0.517													T	175896768	T	T	175896768	3	4	28	1	0	0	0	0	1	0	0	0	247	652	23	2	94	2	ADAM29	4	175896768	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08	104429509	175896768	15257508	17	1813											
ZDHHC11	79844	broad.mit.edu	37	chr5	837585	837585	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agatactcaaaggtggtcatCttcttggcctctggaaaggg	12	8	5	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr5:837585C>T	uc011cma.1	-	6	1179	c.795G>A	c.(793-795)AAG>AAA	p.K265K	ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	265						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			AGGTGGTCATCTTCTTGGCCT	0.502													T	837585	T	T	837585	2	4	28	1	0	0	0	0	0	0	0	1	17598	912	32	3		3	ZDHHC11	5	837585	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08		837585	180077675	18	1814											
EDIL3	10085	broad.mit.edu	37	chr5	83433171	83433171	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaacttcgcattcatttatGtctaagaaaaacagaaagga	6	7	3	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr5:83433171G>A	uc003kio.1	-	5	776	c.357C>T	c.(355-357)AAC>AAT	p.N119N	EDIL3_uc003kip.1_Silent_p.N109N	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	119	EGF-like 3.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		ATTCATTTATGTCTAAGAAAA	0.338													A	83433171	A	A	83433171	2	1	28	1	0	0	0	0	0	0	0	1	4915	1391	48	3		3	EDIL3	5	83433171	Silent	SNP	G	TCGA-06-0158-01A-01D-1491-08	82595586	83433171	97482089	19	1815											
PCDHGA10	56106	broad.mit.edu	37	chr5	140794507	140794507	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgccccgctccgcagagcccGgctacctggtgaccaaggtg	13	17	0	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr5:140794507G>A	uc003lkl.1	+	1	1765	c.1765G>A	c.(1765-1767)GGC>AGC	p.G589S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.G589S|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	589	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCAGAGCCCGGCTACCTGGT	0.677													A	140794507	A	A	140794507	3	1	28	1	0	0	0	0	1	0	0	0	11551	1116	39	2	1767	2	PCDHGA10	5	140794507	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	57361336	140794507	40120753	20	1816											
TRIM38	10475	broad.mit.edu	37	chr6	25966964	25966964	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catttcatatggatagcctcCgacccaacaagcagctggga	9	12	1	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr6:25966964C>T	uc003nfm.2	+	3	649	c.214C>T	c.(214-216)CGA>TGA	p.R72*	TRIM38_uc003nfn.2_Nonsense_Mutation_p.R72*	NM_006355	NP_006346	O00635	TRI38_HUMAN	tripartite motif-containing 38	72					positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular	signal transducer activity|zinc ion binding				0						GGATAGCCTCCGACCCAACAA	0.498													T	25966964	T	T	25966964	4	4	28	1	0	0	0	0	0	1	0	0	16509	644	23	2	216	2	TRIM38	6	25966964	Nonsense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08		25966964	145148103	21	1817											
HLA-F	3134	broad.mit.edu	37	chr6	29694676	29694676	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcctactcagtggtcagCggaaacttgatgataacatg	10	9	2	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr6:29694676C>T	uc003nno.3	+	7	1177	c.1053C>T	c.(1051-1053)AGC>AGT	p.S351S	HLA-F_uc011dlx.1_Silent_p.S351S|HLA-F_uc011dly.1_RNA|LOC285830_uc003nnp.2_RNA|LOC285830_uc011dlz.1_RNA	NM_001098479	NP_001091949	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	Error:Variant_position_missing_in_P30511_after_alignment					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						CAGTGGTCAGCGGAAACTTGA	0.493													T	29694676	T	T	29694676	2	4	28	1	0	0	0	0	0	0	0	1	7211	767	27	1		1	HLA-F	6	29694676	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08	3727712	29694676	141420391	22	1818											
CRISP3	10321	broad.mit.edu	37	chr6	49704218	49704218	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aacaaagcagtaaaagcgggAtcctaagggaaaataaaatt	9	5	0	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr6:49704218A>G	uc003ozs.2	-	3	90	c.75T>C	c.(73-75)GAT>GAC	p.D25D		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	25					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TAAAAGCGGGATCCTAAGGGA	0.363													G	49704218	G	G	49704218	2	3	28	1	0	0	0	0	0	0	0	1	3881	330	12	4		4	CRISP3	6	49704218	Silent	SNP	A	TCGA-06-0158-01A-01D-1491-08	20009542	49704218	121410849	23	1819											
POM121L12	285877	broad.mit.edu	37	chr7	53103391	53103391	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcagctccggccgagtcCgcagacctcgggaacttctg	13	15	1	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr7:53103391C>T	uc003tpz.2	+	1	43	c.27C>T	c.(25-27)TCC>TCT	p.S9S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	9											0						CGGCCGAGTCCGCAGACCTCG	0.697													T	53103391	T	T	53103391	2	4	28	1	0	0	0	0	0	0	0	1	12241	639	23	2		2	POM121L12	7	53103391	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08		53103391	106035272	24	1820											
EGFR	1956	broad.mit.edu	37	chr7	55211080	55211080	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggaaaacctgcagatcatcaGaggaaatatgtactacgaaa	9	7	2	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr7:55211080G>A	uc003tqk.2	+	3	569	c.323G>A	c.(322-324)AGA>AAA	p.R108K	EGFR_uc003tqh.2_Missense_Mutation_p.R108K|EGFR_uc003tqi.2_Missense_Mutation_p.R108K|EGFR_uc003tqj.2_Missense_Mutation_p.R108K|EGFR_uc010kzg.1_Missense_Mutation_p.R108K|EGFR_uc011kco.1_Missense_Mutation_p.R55K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	108	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R108K(7)|p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGATCATCAGAGGAAATATG	0.423		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55211080	A	A	55211080	3	1	28	1	0	0	0	0	1	0	0	0	4967	942	33	3	333	3	EGFR	7	55211080	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	2107689	55211080	103927583	25	1821											
EGFR	1956	broad.mit.edu	37	chr7	55233036	55233036	+	Missense_Mutation	SNP	C	T	T													cccactgcgtcaagacctgcCcggcaggagtcatgggagaa							TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr7:55233036C>T	uc003tqk.2	+	15	2032	c.1786C>T	c.(1786-1788)CCG>TCG	p.P596S	EGFR_uc003tqi.2_Missense_Mutation_p.P596S|EGFR_uc003tqj.2_Missense_Mutation_p.P596S|EGFR_uc010kzg.1_Missense_Mutation_p.P551S|EGFR_uc011kco.1_Missense_Mutation_p.P543S|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	596	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.P596L(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAAGACCTGCCCGGCAGGAGT	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233036	T	T	55233036	3	4	28	1	0	0	0	0	1	0	0	0	4967	623	22	3	1855	3	EGFR	7	55233036	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08	21956	55233036	103905627	26	1822	1	2									
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	C	C													cgtcaagacctgcccggcagGagtcatgggagaaaacaaca					rs139236063		TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr7:55233043G>C	uc003tqk.2	+	15	2039	c.1793G>C	c.(1792-1794)GGA>GCA	p.G598A	EGFR_uc003tqi.2_Missense_Mutation_p.G598A|EGFR_uc003tqj.2_Missense_Mutation_p.G598A|EGFR_uc010kzg.1_Missense_Mutation_p.G553A|EGFR_uc011kco.1_Missense_Mutation_p.G545A|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			C	55233043	C	C	55233043	3	2	28	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	7	55233043	103905620	27	1823	1	2									
PCLO	27445	broad.mit.edu	37	chr7	82764904	82764904	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtttgggctggggtgatgaCggaactggagccagatcccc	16	9	0	3			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr7:82764904C>T	uc003uhx.2	-	3	2251	c.1962G>A	c.(1960-1962)CCG>CCA	p.P654P	PCLO_uc003uhv.2_Silent_p.P654P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	600	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGGGTGATGACGGAACTGGAG	0.478													T	82764904	T	T	82764904	2	4	28	1	0	0	0	0	0	0	0	1	11583	523	19	1		1	PCLO	7	82764904	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08	27531861	82764904	76373759	28	1824											
NPTX2	4885	broad.mit.edu	37	chr7	98254472	98254472	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccatcgagctgctcatcaaCgacaaggtgaggcccgcctg	11	15	2	1	rs149672697		TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr7:98254472C>T	uc003upl.2	+	3	1059	c.882C>T	c.(880-882)AAC>AAT	p.N294N		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	294	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding	p.N294N(1)		central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			TGCTCATCAACGACAAGGTGA	0.667													T	98254472	T	T	98254472	2	4	28	1	0	0	0	0	0	0	0	1	10603	535	19	1		1	NPTX2	7	98254472	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08	15489568	98254472	60884191	29	1825											
LAMB1	3912	broad.mit.edu	37	chr7	107600136	107600136	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgcttttgaggaacctacGtttgcatccactggggccaa	10	10	0	1	rs140619520		TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr7:107600136G>A	uc003vew.2	-	19	2793	c.2458C>T	c.(2458-2460)CCT>TCT	p.P820S	LAMB1_uc003vev.2_Missense_Mutation_p.P844S|LAMB1_uc003vex.2_Missense_Mutation_p.R820C	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	820	Laminin EGF-like 6.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGAACCTACGTTTGCATCCA	0.527													A	107600136	A	A	107600136	3	1	28	1	0	0	0	0	1	0	0	0	8610	1159	40	1	2966	1	LAMB1	7	107600136	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	9345664	107600136	51538527	30	1826											
ASB15	142685	broad.mit.edu	37	chr7	123276864	123276864	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttttcccgatttcttttagaGaatccttgttcattgaagca	6	8	2	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr7:123276864G>A	uc003vku.1	+	12	1888	c.1596G>A	c.(1594-1596)GAG>GAA	p.E532E	ASB15_uc003vkw.1_Silent_p.E532E	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	532	SOCS box.				intracellular signal transduction					skin(2)|lung(1)	3						TTCTTTTAGAGAATCCTTGTT	0.383													A	123276864	A	A	123276864	2	1	28	1	0	0	0	0	0	0	0	1	1019	956	33	3		3	ASB15	7	123276864	Silent	SNP	G	TCGA-06-0158-01A-01D-1491-08	15676728	123276864	35861799	31	1827											
NUP205	23165	broad.mit.edu	37	chr7	135300745	135300745	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagggtaacctctctgaatcGtcagcggtcacatacccaga	9	12	3	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr7:135300745G>A	uc003vsw.2	+	24	3423	c.3392G>A	c.(3391-3393)CGT>CAT	p.R1131H		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1131					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						TCTCTGAATCGTCAGCGGTCA	0.403													A	135300745	A	A	135300745	3	1	28	1	0	0	0	0	1	0	0	0	10759	1145	40	1	3486	1	NUP205	7	135300745	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	12023881	135300745	23837918	32	1828											
TRPA1	8989	broad.mit.edu	37	chr8	72948640	72948640	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacaaaaatgatgcccgtcGtgtagataatccattcaaga	8	9	1	3			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr8:72948640G>A	uc003xza.2	-	21	2613	c.2438C>T	c.(2437-2439)ACG>ATG	p.T813M	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	813	Helical; Name=3; (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GATGCCCGTCGTGTAGATAAT	0.363													A	72948640	A	A	72948640	3	1	28	1	0	0	0	0	1	0	0	0	16574	1145	40	1	949	1	TRPA1	8	72948640	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08		72948640	73415382	33	1829											
SPTAN1	6709	broad.mit.edu	37	chr9	131395212	131395212	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctcagagggaaagccttacgTgaccaaggaggagctctacc	12	11	2	2	rs148173166		TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr9:131395212T>A	uc004bvl.3	+	55	7384	c.7271T>A	c.(7270-7272)GTG>GAG	p.V2424E	SPTAN1_uc004bvm.3_Missense_Mutation_p.V2429E|SPTAN1_uc004bvn.3_Missense_Mutation_p.V2404E|SPTAN1_uc004bvo.3_Missense_Mutation_p.V191E|SPTAN1_uc004bvp.3_Missense_Mutation_p.V167E	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2424	EF-hand 3.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AAGCCTTACGTGACCAAGGAG	0.547													A	131395212	A	A	131395212	3	1	28	1	0	0	0	0	1	0	0	0	15116	1696	59	5	7504	5	SPTAN1	9	131395212	Missense_Mutation	SNP	T	TCGA-06-0158-01A-01D-1491-08		131395212	9818219	34	1830											
C9orf171	389799	broad.mit.edu	37	chr9	135374872	135374872	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ccggcctggtgactgcccggGagaacttgctctaccgtcag	13	14	2	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr9:135374872G>C	uc004cbn.2	+	4	565	c.517G>C	c.(517-519)GAG>CAG	p.E173Q	C9orf171_uc004cbo.2_Missense_Mutation_p.E137Q	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	173										ovary(4)|large_intestine(1)	5						GACTGCCCGGGAGAACTTGCT	0.592													C	135374872	C	C	135374872	3	2	28	1	0	0	0	0	1	0	0	0	2470	1175	41	5	531	5	C9orf171	9	135374872	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	3979660	135374872	5838559	35	1831											
ANO5	203859	broad.mit.edu	37	chr11	22291884	22291884	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttgaattggtggagacgccGaaaagctcggacaaactctg	12	8	1	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr11:22291884G>A	uc001mqi.2	+	18	2242	c.1925G>A	c.(1924-1926)CGA>CAA	p.R642Q	ANO5_uc001mqj.2_Missense_Mutation_p.R641Q	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	642	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TGGAGACGCCGAAAAGCTCGG	0.413													A	22291884	A	A	22291884	3	1	28	1	0	0	0	0	1	0	0	0	700	1058	37	2	1995	2	ANO5	11	22291884	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08		22291884	112714632	36	1832											
GDPD4	220032	broad.mit.edu	37	chr11	76956338	76956338	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agacttaccagatgttgctcGattttagaggcaaggatcac	10	8	1	3			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr11:76956338G>A	uc001oyf.2	-	11	1325	c.1074C>T	c.(1072-1074)ATC>ATT	p.I358I		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	358	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						GATGTTGCTCGATTTTAGAGG	0.438													A	76956338	A	A	76956338	2	1	28	1	0	0	0	0	0	0	0	1	6326	1048	37	2		2	GDPD4	11	76956338	Silent	SNP	G	TCGA-06-0158-01A-01D-1491-08	54664454	76956338	58050178	37	1833											
GRM5	2915	broad.mit.edu	37	chr11	88338071	88338071	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccataggccatcgaatagatGgcgttgatcacaaatcccat	8	11	1	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr11:88338071G>A	uc001pcq.2	-	4	1409	c.1209C>T	c.(1207-1209)GCC>GCT	p.A403A	GRM5_uc009yvm.2_Silent_p.A403A	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	403	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TCGAATAGATGGCGTTGATCA	0.458													A	88338071	A	A	88338071	2	1	28	1	0	0	0	0	0	0	0	1	6800	1335	47	3		3	GRM5	11	88338071	Silent	SNP	G	TCGA-06-0158-01A-01D-1491-08	11381733	88338071	46668445	38	1834											
NAALAD2	10003	broad.mit.edu	37	chr11	89902152	89902152	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttatatcaactcggattcatCtatagaaggtaaattttatt	5	5	3	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr11:89902152C>G	uc001pdf.3	+	12	1443	c.1334C>G	c.(1333-1335)TCT>TGT	p.S445C	NAALAD2_uc009yvx.2_Missense_Mutation_p.S412C|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	445	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TCGGATTCATCTATAGAAGGT	0.294													G	89902152	G	G	89902152	3	3	28	1	0	0	0	0	1	0	0	0	10128	913	32	5	1380	5	NAALAD2	11	89902152	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08	1564081	89902152	45104364	39	1835											
APOF	319	broad.mit.edu	37	chr12	56755752	56755752	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caagaacttgggtagaggggCcatgtggctgaaaccaggca	15	8	0	3			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr12:56755752C>G	uc001sle.1	-	2	292	c.238G>C	c.(238-240)GCC>CCC	p.A80P		NM_001638	NP_001629	Q13790	APOF_HUMAN	apolipoprotein F precursor	80					cholesterol metabolic process	high-density lipoprotein particle|low-density lipoprotein particle	cholesterol binding|lipid transporter activity|receptor binding				0						GGTAGAGGGGCCATGTGGCTG	0.547													G	56755752	G	G	56755752	3	3	28	1	0	0	0	0	1	0	0	0	803	739	26	5	746	5	APOF	12	56755752	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08		56755752	77096143	40	1836											
MDM1	56890	broad.mit.edu	37	chr12	68716856	68716856	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	taaaagttgatgaataccttCctttcaggagacactgtttc	7	8	1	3			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr12:68716856C>T	uc001stz.2	-	5	934	c.798G>A	c.(796-798)AGG>AGA	p.R266R	MDM1_uc010stc.1_Silent_p.R221R|MDM1_uc009zqv.1_5'UTR	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	266						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		TGAATACCTTCCTTTCAGGAG	0.328													T	68716856	T	T	68716856	2	4	28	1	0	0	0	0	0	0	0	1	9412	854	30	3		3	MDM1	12	68716856	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08	11961104	68716856	65135039	41	1837											
RALGAPA1	253959	broad.mit.edu	37	chr14	36211763	36211763	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctgcttcacaaattggtaaTaaaaatgcctagggaaaaaa	8	6	1	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr14:36211763T>C	uc001wti.2	-	11	1651	c.1260A>G	c.(1258-1260)TTA>TTG	p.L420L	RALGAPA1_uc001wtj.2_Silent_p.L420L|RALGAPA1_uc010tpv.1_Silent_p.L420L|RALGAPA1_uc010tpw.1_Silent_p.L420L|RALGAPA1_uc001wtk.1_Silent_p.L271L	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	420					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AAATTGGTAATAAAAATGCCT	0.308													C	36211763	C	C	36211763	2	2	28	1	0	0	0	0	0	0	0	1	13013	1403	49	4		4	RALGAPA1	14	36211763	Silent	SNP	T	TCGA-06-0158-01A-01D-1491-08		36211763	71137777	42	1838											
RFX7	64864	broad.mit.edu	37	chr15	56435018	56435018	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttgggcagtgaagtctccGgatgttcctctagggtattc	13	8	2	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr15:56435018G>A	uc010bfn.2	-	4	359	c.359C>T	c.(358-360)CCG>CTG	p.P120L		NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	23	RFX-type winged-helix.				regulation of transcription, DNA-dependent	nucleus	DNA binding				0						TGAAGTCTCCGGATGTTCCTC	0.388													A	56435018	A	A	56435018	3	1	28	1	0	0	0	0	1	0	0	0	13268	1116	39	2	4047	2	RFX7	15	56435018	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08		56435018	46096374	43	1839											
WDR90	197335	broad.mit.edu	37	chr16	703568	703568	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagcagctcactattggcctCggcccaggcaagggccccta	11	16	1	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr16:703568C>T	uc002cii.1	+	12	1331	c.1277C>T	c.(1276-1278)TCG>TTG	p.S426L	WDR90_uc002cig.1_Missense_Mutation_p.S426L|WDR90_uc002cih.1_Missense_Mutation_p.S427L|WDR90_uc002cij.1_RNA|WDR90_uc002cik.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	426	WD 1.									ovary(1)	1		Hepatocellular(780;0.0218)				CTATTGGCCTCGGCCCAGGCA	0.657													T	703568	T	T	703568	3	4	28	1	0	0	0	0	1	0	0	0	17334	893	31	2	1323	2	WDR90	16	703568	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08		703568	89651185	44	1840											
CORO7	79585	broad.mit.edu	37	chr16	4391505	4391505	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	catcagctgcggcccggctgGctgtgtggacatgtgggtga	17	10	1	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr16:4391505G>C	uc002cwf.2	-	29	3301	c.2858C>G	c.(2857-2859)GCC>GGC	p.A953G	CORO7_uc002cwe.2_RNA|TIMM16_uc002cwd.2_Missense_Mutation_p.A30G	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						GGCCCGGCTGGCTGTGTGGAC	0.657													C	4391505	C	C	4391505	3	2	28	1	0	0	0	0	1	0	0	0	3759	1217	42	5		5	CORO7	16	4391505	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	3687937	4391505	85963248	45	1841											
SLC25A11	8402	broad.mit.edu	37	chr17	4842250	4842250	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagtggtgtaggtggcctgaCgcagcaggccagccgacagc	16	11	0	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr17:4842250C>T	uc002fzo.1	-	3	382	c.269G>A	c.(268-270)CGT>CAT	p.R90H	SLC25A11_uc002fzp.1_Missense_Mutation_p.R86H|RNF167_uc002fzq.2_5'Flank|RNF167_uc002fzr.2_5'Flank|RNF167_uc002fzs.2_5'Flank|RNF167_uc002fzt.2_5'Flank|RNF167_uc002fzu.2_5'Flank|RNF167_uc002fzv.2_5'Flank|RNF167_uc002fzw.1_5'Flank|RNF167_uc002fzx.2_5'Flank	NM_003562	NP_003553	Q02978	M2OM_HUMAN	solute carrier family 25 member 11 isoform 1	90	Helical; Name=2; (Potential).|Solcar 1.				gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity				0						GGTGGCCTGACGCAGCAGGCC	0.612													T	4842250	T	T	4842250	3	4	28	1	0	0	0	0	1	0	0	0	14473	536	19	1	699	1	SLC25A11	17	4842250	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08		4842250	76352960	46	1842											
TMEM102	284114	broad.mit.edu	37	chr17	7340213	7340213	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttcaccaccgtcctcctggcTacccctgagccccctcgccg	7	22	1	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr17:7340213T>A	uc002ggx.1	+	3	1188	c.915T>A	c.(913-915)GCT>GCA	p.A305A	FGF11_uc010vtw.1_Intron|TMEM102_uc002ggy.1_Silent_p.A305A|FGF11_uc010cmh.1_5'Flank|FGF11_uc010cmi.2_5'Flank|FGF11_uc002ggz.2_5'Flank	NM_178518	NP_848613	Q8N9M5	TM102_HUMAN	transmembrane protein 102	305	Cytoplasmic (Potential).				regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding				0		Prostate(122;0.173)				TCCTCCTGGCTACCCCTGAGC	0.721													A	7340213	A	A	7340213	2	1	28	1	0	0	0	0	0	0	0	1	16014	1509	53	5		5	TMEM102	17	7340213	Silent	SNP	T	TCGA-06-0158-01A-01D-1491-08	2497963	7340213	73854997	47	1843											
KRBA2	124751	broad.mit.edu	37	chr17	8274702	8274702	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgagagccttctaaataatTccaatctttggtcatatttt	5	7	3	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr17:8274702T>G	uc002glf.1	-	1	157	c.151A>C	c.(151-153)AAT>CAT	p.N51H	KRBA2_uc002glg.1_Intron	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	51	KRAB.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						TCTAAATAATTCCAATCTTTG	0.453													G	8274702	G	G	8274702	3	3	28	1	0	0	0	0	1	0	0	0	8440	1783	62	5	1335	5	KRBA2	17	8274702	Missense_Mutation	SNP	T	TCGA-06-0158-01A-01D-1491-08	934489	8274702	72920508	48	1844											
UNC45B	146862	broad.mit.edu	37	chr17	33497185	33497185	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgacgctgggcagtggagGgcctggcctacctcacgctg	15	15	1	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr17:33497185G>A	uc002hja.2	+	12	1697	c.1600G>A	c.(1600-1602)GGC>AGC	p.G534S	UNC45B_uc002hjb.2_Missense_Mutation_p.G534S|UNC45B_uc002hjc.2_Missense_Mutation_p.G534S|UNC45B_uc010cto.2_Intron	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	534					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				GGCAGTGGAGGGCCTGGCCTA	0.627													A	33497185	A	A	33497185	3	1	28	1	0	0	0	0	1	0	0	0	16986	1232	43	3	1642	3	UNC45B	17	33497185	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	25222483	33497185	47698025	49	1845											
TMC6	11322	broad.mit.edu	37	chr17	76120076	76120076	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtggaggcattacctgtacAccagggtgatgcaggtgata	15	7	0	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr17:76120076A>C	uc002juj.1	-	8	1202	c.1076T>G	c.(1075-1077)GTG>GGG	p.V359G	TMC6_uc002jui.1_5'Flank|TMC6_uc010dhf.1_Missense_Mutation_p.V192G|TMC6_uc002juk.2_Missense_Mutation_p.V359G|TMC6_uc010dhg.1_Missense_Mutation_p.V359G|TMC6_uc002jul.1_Missense_Mutation_p.V359G|TMC6_uc002jum.3_Missense_Mutation_p.V150G|TMC6_uc002jun.3_Missense_Mutation_p.V359G|TMC6_uc002juo.2_Missense_Mutation_p.V132G	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	359	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TTACCTGTACACCAGGGTGAT	0.428									Epidermodysplasia_Verruciformis_Familial_Clustering_of				C	76120076	C	C	76120076	3	2	28	1	0	0	0	0	1	0	0	0	15986	159	6	5	1389	5	TMC6	17	76120076	Missense_Mutation	SNP	A	TCGA-06-0158-01A-01D-1491-08	42622891	76120076	5075134	50	1846											
CANT1	124583	broad.mit.edu	37	chr17	76989644	76989644	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gttttgagttaaatgaactcGatgccttcgtatttcacgct	8	8	1	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr17:76989644G>C	uc002jwn.2	-	6	1633	c.1194C>G	c.(1192-1194)ATC>ATG	p.I398M	CANT1_uc002jwk.2_Missense_Mutation_p.I398M|CANT1_uc002jwj.2_Missense_Mutation_p.I398M|CANT1_uc002jwl.2_Intron|CANT1_uc002jwm.1_RNA	NM_001159772	NP_001153244	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	398	Lumenal (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity				0			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			AAATGAACTCGATGCCTTCGT	0.478			T	ETV4	prostate						OREG0024788	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	76989644	C	C	76989644	3	2	28	1	0	0	0	0	1	0	0	0	2617	1048	37	5	15	5	CANT1	17	76989644	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	869568	76989644	4205566	51	1847											
RPTOR	57521	broad.mit.edu	37	chr17	78797000	78797000	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcagcagcccgcgtctgccGcccacgtacatgcacgccat	10	18	2	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr17:78797000G>A	uc002jyt.1	+	9	1918	c.1113G>A	c.(1111-1113)CCG>CCA	p.P371P	RPTOR_uc002jys.2_Silent_p.P371P|RPTOR_uc010wuf.1_Silent_p.P186P|RPTOR_uc010wug.1_Silent_p.P371P	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	371					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CGCGTCTGCCGCCCACGTACA	0.562													A	78797000	A	A	78797000	2	1	28	1	0	0	0	0	0	0	0	1	13665	1074	38	1		1	RPTOR	17	78797000	Silent	SNP	G	TCGA-06-0158-01A-01D-1491-08	1807356	78797000	2398210	52	1848											
TMX3	54495	broad.mit.edu	37	chr18	66377374	66377374	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacaatggccacaccatggcGcataaaacttgttttaaaaa	6	9	0	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr18:66377374G>A	uc002lkf.2	-	4	284	c.149C>T	c.(148-150)GCG>GTG	p.A50V	TMX3_uc010xez.1_5'UTR|TMX3_uc010xfa.1_Missense_Mutation_p.A50V|TMX3_uc002lkg.3_Missense_Mutation_p.A50V	NM_019022	NP_061895	Q96JJ7	TMX3_HUMAN	thioredoxin domain containing 10 precursor	50	Thioredoxin.|Lumenal (Potential).				cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			skin(1)	1						ACACCATGGCGCATAAAACTT	0.323													A	66377374	A	A	66377374	3	1	28	1	0	0	0	0	1	0	0	0	16265	1087	38	1	1267	1	TMX3	18	66377374	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08		66377374	11699874	53	1849											
RTTN	25914	broad.mit.edu	37	chr18	67718690	67718690	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagggccacggtaacaaaCgggagtgtgatggcaccagc	15	11	0	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr18:67718690C>T	uc002lkp.2	-	39	5348	c.5280G>A	c.(5278-5280)CCG>CCA	p.P1760P	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.P848P|RTTN_uc010dqp.2_Silent_p.P12P	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1760							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				CGGTAACAAACGGGAGTGTGA	0.428													T	67718690	T	T	67718690	2	4	28	1	0	0	0	0	0	0	0	1	13737	523	19	1		1	RTTN	18	67718690	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08	1341316	67718690	10358558	54	1850											
ODF3L2	284451	broad.mit.edu	37	chr19	463966	463966	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggagccctggctttgttcaCggtgacctgctctgggcagt	14	11	2	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr19:463966C>T	uc002lor.2	-	4	984	c.748G>A	c.(748-750)GTG>ATG	p.V250M	SHC2_uc002loq.3_5'Flank|ODF3L2_uc010drp.2_Missense_Mutation_p.V214M	NM_182577	NP_872383	Q3SX64	OD3L2_HUMAN	outer dense fiber of sperm tails 3-like 2	250	DUF1309 3.										0						GCTTTGTTCACGGTGACCTGC	0.627													T	463966	T	T	463966	3	4	28	1	0	0	0	0	1	0	0	0	10832	536	19	1	125	1	ODF3L2	19	463966	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08		463966	58665017	55	1851											
PIAS4	51588	broad.mit.edu	37	chr19	4012940	4012940	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaacatggtgatgagttttcGagtctccgaccttcagatgc	11	9	2	3			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr19:4012940G>A	uc002lzg.2	+	2	57	c.47G>A	c.(46-48)CGA>CAA	p.R16Q		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	16	SAP.				positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGAGTTTTCGAGTCTCCGAC	0.597													A	4012940	A	A	4012940	3	1	28	1	0	0	0	0	1	0	0	0	11878	1058	37	2	53	2	PIAS4	19	4012940	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	3548974	4012940	55116043	56	1852											
ICAM4	3386	broad.mit.edu	37	chr19	10398368	10398368	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgaaagcctggagcgcttcaCcggcctggatctggccaacg	13	14	2	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr19:10398368C>G	uc002mns.1	+	2	590	c.551C>G	c.(550-552)ACC>AGC	p.T184S	ICAM4_uc002mnr.1_Missense_Mutation_p.H158Q|ICAM4_uc002mnt.1_Missense_Mutation_p.T184S|ICAM5_uc002mnu.3_5'Flank	NM_001544	NP_001535	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 isoform 1	184	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			GAGCGCTTCACCGGCCTGGAT	0.627													G	10398368	G	G	10398368	3	3	28	1	0	0	0	0	1	0	0	0	7482	507	18	5	557	5	ICAM4	19	10398368	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08	6385428	10398368	48730615	57	1853											
RGL3	57139	broad.mit.edu	37	chr19	11526629	11526629	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacctgtccacacctgaggCggctcctcttcctgctctcg	8	18	3	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr19:11526629C>T	uc002mrp.2	-	5	685	c.621G>A	c.(619-621)CCG>CCA	p.P207P	RGL3_uc002mrn.2_5'UTR|RGL3_uc002mrm.2_5'UTR|RGL3_uc002mro.2_Silent_p.P207P	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	207					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						ACACCTGAGGCGGCTCCTCTT	0.567													T	11526629	T	T	11526629	2	4	28	1	0	0	0	0	0	0	0	1	13278	755	27	1		1	RGL3	19	11526629	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08	1128261	11526629	47602354	58	1854											
ZNF91	7644	broad.mit.edu	37	chr19	23545038	23545038	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagtaagggttgagagctgcTtaaaagctttgccacattct	10	7	1	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr19:23545038T>C	uc002nre.2	-	4	856	c.743A>G	c.(742-744)AAG>AGG	p.K248R	ZNF91_uc010xrj.1_Missense_Mutation_p.K216R	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	248	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGAGAGCTGCTTAAAAGCTTT	0.363													C	23545038	C	C	23545038	3	2	28	1	0	0	0	0	1	0	0	0	18197	1609	56	4	2836	4	ZNF91	19	23545038	Missense_Mutation	SNP	T	TCGA-06-0158-01A-01D-1491-08	12018409	23545038	35583945	59	1855											
HIPK4	147746	broad.mit.edu	37	chr19	40886782	40886782	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcttcccctccacttgcagCgagaggcggtagctgcgcag	14	14	0	1	rs148513270	byFrequency	TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr19:40886782C>T	uc002onp.2	-	3	1401	c.1116G>A	c.(1114-1116)TCG>TCA	p.S372S		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	372						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CCACTTGCAGCGAGAGGCGGT	0.667													T	40886782	T	T	40886782	2	4	28	1	0	0	0	0	0	0	0	1	7119	755	27	1		1	HIPK4	19	40886782	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08	17341744	40886782	18242201	60	1856											
NLRP11	204801	broad.mit.edu	37	chr19	56320789	56320789	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagccagcaaacacagaCgttttaggagacctaggtga	11	10	0	3			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr19:56320789C>T	uc010ygf.1	-	5	1898	c.1187G>A	c.(1186-1188)CGT>CAT	p.R396H	NLRP11_uc002qlz.2_Missense_Mutation_p.R297H|NLRP11_uc002qmb.2_Missense_Mutation_p.R297H|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	396	NACHT.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CAAACACAGACGTTTTAGGAG	0.493													T	56320789	T	T	56320789	3	4	28	1	0	0	0	0	1	0	0	0	10473	536	19	1	1946	1	NLRP11	19	56320789	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08	15434007	56320789	2808194	61	1857											
SEMG1	6406	broad.mit.edu	37	chr20	43836290	43836290	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagaaggcagagaccatgatAaatcaaaaggtcattttcac	8	7	3	3			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr20:43836290A>G	uc002xni.2	+	2	409	c.352A>G	c.(352-354)AAA>GAA	p.K118E	SEMG1_uc002xnj.2_Missense_Mutation_p.K118E|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.K118E	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	118					insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				AGACCATGATAAATCAAAAGG	0.408													G	43836290	G	G	43836290	3	3	28	1	0	0	0	0	1	0	0	0	14044	363	13	4	358	4	SEMG1	20	43836290	Missense_Mutation	SNP	A	TCGA-06-0158-01A-01D-1491-08		43836290	19189230	62	1858											
MC3R	4159	broad.mit.edu	37	chr20	54824329	54824329	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatcgccgtcgacaggtacGtcaccatcttttacgcgctc	8	16	2	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr20:54824329G>A	uc002xxb.2	+	1	542	c.430G>A	c.(430-432)GTC>ATC	p.V144I		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	181	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			CGACAGGTACGTCACCATCTT	0.582													A	54824329	A	A	54824329	3	1	28	1	0	0	0	0	1	0	0	0	9365	1145	40	1	432	1	MC3R	20	54824329	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	10988039	54824329	8201191	63	1859											
ITGB2	3689	broad.mit.edu	37	chr21	46320234	46320234	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcctggggtggggacttaCgaattcgttgctcctcttgt	14	9	1	0			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr21:46320234C>T	uc002zgd.2	-	6	941	c.897_splice	c.e6+1	p.F299_splice	ITGB2_uc002zge.2_Splice_Site_p.F299_splice|ITGB2_uc002zgf.3_Splice_Site_p.F299_splice|ITGB2_uc011afl.1_Splice_Site_p.F221_splice|ITGB2_uc010gpw.2_Splice_Site_p.F242_splice|ITGB2_uc002zgg.2_Splice_Site_p.F299_splice	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor						apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity	p.?(1)		ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	TGGGGACTTACGAATTCGTTG	0.632													T	46320234	T	T	46320234	5	4	28	1	0	0	0	0	0	0	1	0	7894	550	19	1	1451	1	ITGB2	21	46320234	Splice_Site	SNP	C	TCGA-06-0158-01A-01D-1491-08		46320234	1809661	64	1860											
SGSM1	129049	broad.mit.edu	37	chr22	25315903	25315903	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctctggtggaagtctacCgtgacatcattttggagaac	12	8	3	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr22:25315903C>T	uc003abg.2	+	25	3458	c.3301C>T	c.(3301-3303)CGT>TGT	p.R1101C	SGSM1_uc003abh.2_Missense_Mutation_p.R1040C|SGSM1_uc010guu.1_Missense_Mutation_p.R1046C|SGSM1_uc003abj.2_Missense_Mutation_p.R985C|SGSM1_uc003abi.1_Missense_Mutation_p.R1021C	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	1101						Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5						GGAAGTCTACCGTGACATCAT	0.507													T	25315903	T	T	25315903	3	4	28	1	0	0	0	0	1	0	0	0	14222	652	23	2	3399	2	SGSM1	22	25315903	Missense_Mutation	SNP	C	TCGA-06-0158-01A-01D-1491-08		25315903	25988663	65	1861											
THOC5	8563	broad.mit.edu	37	chr22	29913061	29913061	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtagtagagattggtgtcCccagccagtcccgcatccac	10	13	0	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chr22:29913061C>T	uc003afr.2	-	18	1973	c.1638G>A	c.(1636-1638)GGG>GGA	p.G546G	THOC5_uc003afq.2_Silent_p.G207G|THOC5_uc003afs.2_Silent_p.G546G|THOC5_uc003aft.2_Silent_p.G546G|THOC5_uc003afu.2_Silent_p.G546G|THOC5_uc010gvo.2_Silent_p.G290G	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	546					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						GATTGGTGTCCCCAGCCAGTC	0.527													T	29913061	T	T	29913061	2	4	28	1	0	0	0	0	0	0	0	1	15865	610	22	3		3	THOC5	22	29913061	Silent	SNP	C	TCGA-06-0158-01A-01D-1491-08	4597158	29913061	21391505	66	1862											
FAM46D	169966	broad.mit.edu	37	chrX	79699116	79699116	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgtactttgcagctgaggcaAggtaccctatttatgtaata	9	8	0	1			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chrX:79699116A>T	uc004edl.1	+	5	1412	c.1078A>T	c.(1078-1080)AGG>TGG	p.R360W	FAM46D_uc004edm.1_Missense_Mutation_p.R360W	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	360										lung(2)	2						AGCTGAGGCAAGGTACCCTAT	0.428													T	79699116	T	T	79699116	3	4	28	1	0	0	0	0	1	0	0	0	5568	63	3	5	1080	5	FAM46D	23	79699116	Missense_Mutation	SNP	A	TCGA-06-0158-01A-01D-1491-08		79699116	75571444	67	1863											
SPRY3	10251	broad.mit.edu	37	chrX	155004303	155004303	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggctatgatagcctccggcGaccaggctgccgctgcaaga	14	13	0	2			TCGA-06-0158-01A-01D-1491-08	TCGA-06-0158-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	14580533-4a0c-47ca-bb51-c233700de35c	afd6f8db-e121-4613-ab8d-154b04e013bf	g.chrX:155004303G>A	uc004fnq.1	+	2	1224	c.770G>A	c.(769-771)CGA>CAA	p.R257Q	SPRY3_uc010nvl.1_Missense_Mutation_p.R158Q	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	257	SPR.|Cys-rich.				multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AGCCTCCGGCGACCAGGCTGC	0.582													A	155004303	A	A	155004303	3	1	28	1	0	0	0	0	1	0	0	0	15106	1058	37	2	772	2	SPRY3	23	155004303	Missense_Mutation	SNP	G	TCGA-06-0158-01A-01D-1491-08	75305187	155004303	266257	68	1864											
DVL3	1857	broad.mit.edu	37	chr3	183884692	183884692	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggcaccttccctgcatacgGcatgagcccctccctgagca	9	18	0	2			TCGA-06-0165-01A-01D-1491-08	TCGA-06-0165-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	1728988e-0877-4194-92c5-92c1ee6c5f5b	e27b2def-4e82-4c29-bbf1-51d4fffda600	g.chr3:183884692G>A	uc003fms.2	+	11	1267	c.1127G>A	c.(1126-1128)GGC>GAC	p.G376D	DVL3_uc011bqw.1_Missense_Mutation_p.G359D|DVL3_uc003fmt.2_Missense_Mutation_p.G47D|DVL3_uc003fmu.2_Missense_Mutation_p.G208D	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	376					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CCTGCATACGGCATGAGCCCC	0.647													A	183884692	A	A	183884692	3	1	29	1	0	0	0	0	1	0	0	0	4837	1203	42	3	1169	3	DVL3	3	183884692	Missense_Mutation	SNP	G	TCGA-06-0165-01A-01D-1491-08		183884692	14137738	1	1865											
FAT4	79633	broad.mit.edu	37	chr4	126372195	126372195	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atttgatttttggtaatagtCgaaagaagggtttccagatc	10	4	0	3			TCGA-06-0165-01A-01D-1491-08	TCGA-06-0165-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	1728988e-0877-4194-92c5-92c1ee6c5f5b	e27b2def-4e82-4c29-bbf1-51d4fffda600	g.chr4:126372195C>T	uc003ifj.3	+	9	10024	c.10024C>T	c.(10024-10026)CGA>TGA	p.R3342*	FAT4_uc011cgp.1_Nonsense_Mutation_p.R1640*|FAT4_uc003ifi.1_Nonsense_Mutation_p.R820*	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3342	Cadherin 32.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGGTAATAGTCGAAAGAAGGG	0.408													T	126372195	T	T	126372195	4	4	29	1	0	0	0	0	0	1	0	0	5692	876	31	2	10058	2	FAT4	4	126372195	Nonsense_Mutation	SNP	C	TCGA-06-0165-01A-01D-1491-08		126372195	64782081	2	1866											
CCDC110	256309	broad.mit.edu	37	chr4	186380647	186380647	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttaaatctgtaatatttttgCcagtgatgggaatttcttta	7	4	2	1			TCGA-06-0165-01A-01D-1491-08	TCGA-06-0165-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	1728988e-0877-4194-92c5-92c1ee6c5f5b	e27b2def-4e82-4c29-bbf1-51d4fffda600	g.chr4:186380647C>T	uc003ixu.3	-	6	1170	c.1094G>A	c.(1093-1095)GGC>GAC	p.G365D	CCDC110_uc003ixv.3_Missense_Mutation_p.G328D|CCDC110_uc011ckt.1_Missense_Mutation_p.G365D	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	365						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		AATATTTTTGCCAGTGATGGG	0.323													T	186380647	T	T	186380647	3	4	29	1	0	0	0	0	1	0	0	0	2747	739	26	3	1415	3	CCDC110	4	186380647	Missense_Mutation	SNP	C	TCGA-06-0165-01A-01D-1491-08	60008452	186380647	4773629	3	1867											
POM121C	100101267	broad.mit.edu	37	chr7	75051383	75051383	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggggtaagggctggcttggCggcccccggtggctgcccct	19	13	0	0			TCGA-06-0165-01A-01D-1491-08	TCGA-06-0165-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	1728988e-0877-4194-92c5-92c1ee6c5f5b	e27b2def-4e82-4c29-bbf1-51d4fffda600	g.chr7:75051383C>T	uc003udk.3	-	13	3037	c.2152G>A	c.(2152-2154)GCC>ACC	p.A718T		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	960	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						GCTGGCTTGGCGGCCCCCGGT	0.662													T	75051383	T	T	75051383	3	4	29	1	0	0	0	0	1	0	0	0	12240	768	27	1	823	1	POM121C	7	75051383	Missense_Mutation	SNP	C	TCGA-06-0165-01A-01D-1491-08		75051383	84087280	4	1868											
PAX5	5079	broad.mit.edu	37	chr9	37020696	37020696	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcctggagatgtcgcagggcCtgacaccttgatgagcaagt	14	10	0	4			TCGA-06-0165-01A-01D-1491-08	TCGA-06-0165-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	1728988e-0877-4194-92c5-92c1ee6c5f5b	e27b2def-4e82-4c29-bbf1-51d4fffda600	g.chr9:37020696C>A	uc003zzo.1	-	2	597	c.149G>T	c.(148-150)AGG>ATG	p.R50M	PAX5_uc011lpw.1_Missense_Mutation_p.R50M|PAX5_uc011lpx.1_Missense_Mutation_p.R50M|PAX5_uc011lpy.1_Intron|PAX5_uc010mls.1_Missense_Mutation_p.R50M|PAX5_uc011lpz.1_Missense_Mutation_p.R50M|PAX5_uc011lqa.1_Intron|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.R50M|PAX5_uc010mlp.1_Missense_Mutation_p.R50M|PAX5_uc011lqc.1_Missense_Mutation_p.R50M|PAX5_uc010mlr.1_Missense_Mutation_p.R50M|PAX5_uc011lqd.1_Missense_Mutation_p.R49M|PAX5_uc011lqe.1_Intron|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_Intron	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	50	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(31)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		GTCGCAGGGCCTGACACCTTG	0.542			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								A	37020696	A	A	37020696	3	1	29	1	0	0	0	0	1	0	0	0	11482	681	24	5	1062	5	PAX5	9	37020696	Missense_Mutation	SNP	C	TCGA-06-0165-01A-01D-1491-08		37020696	104192735	5	1869											
CEP152	22995	broad.mit.edu	37	chr15	49054838	49054838	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccagcttagactgccactccTtttcaagctgttgaatgagt	8	11	1	3			TCGA-06-0165-01A-01D-1491-08	TCGA-06-0165-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	1728988e-0877-4194-92c5-92c1ee6c5f5b	e27b2def-4e82-4c29-bbf1-51d4fffda600	g.chr15:49054838T>C	uc001zwy.2	-	18	2346	c.2312A>G	c.(2311-2313)AAG>AGG	p.K771R	CEP152_uc001zwz.2_Missense_Mutation_p.K771R|CEP152_uc001zxa.1_Missense_Mutation_p.K678R	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	771	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CTGCCACTCCTTTTCAAGCTG	0.338													C	49054838	C	C	49054838	3	2	29	1	0	0	0	0	1	0	0	0	3248	1609	56	4	2688	4	CEP152	15	49054838	Missense_Mutation	SNP	T	TCGA-06-0165-01A-01D-1491-08		49054838	53476554	6	1870											
ABCC1	4363	broad.mit.edu	37	chr16	16101808	16101808	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctatctctcccgacatgacCgaggctacattcagatgaca	7	13	3	3			TCGA-06-0165-01A-01D-1491-08	TCGA-06-0165-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	1728988e-0877-4194-92c5-92c1ee6c5f5b	e27b2def-4e82-4c29-bbf1-51d4fffda600	g.chr16:16101808C>T	uc010bvi.2	+	2	359	c.184C>T	c.(184-186)CGA>TGA	p.R62*	ABCC1_uc010bvj.2_Nonsense_Mutation_p.R62*|ABCC1_uc010bvk.2_Nonsense_Mutation_p.R62*|ABCC1_uc010bvl.2_Nonsense_Mutation_p.R62*|ABCC1_uc010bvm.2_Nonsense_Mutation_p.R62*|ABCC1_uc002del.3_5'Flank	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	62	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCGACATGACCGAGGCTACAT	0.537													T	16101808	T	T	16101808	4	4	29	1	0	0	0	0	0	1	0	0	49	644	23	2	190	2	ABCC1	16	16101808	Nonsense_Mutation	SNP	C	TCGA-06-0165-01A-01D-1491-08		16101808	74252945	7	1871											
B4GALT6	9331	broad.mit.edu	37	chr18	29225320	29225320	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaaagaatttacctcacctTccatctgggtttacagtctt	6	10	3	1			TCGA-06-0165-01A-01D-1491-08	TCGA-06-0165-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	1728988e-0877-4194-92c5-92c1ee6c5f5b	e27b2def-4e82-4c29-bbf1-51d4fffda600	g.chr18:29225320T>C	uc002kwz.3	-	4	766	c.469A>G	c.(469-471)AAG>GAG	p.K157E	B4GALT6_uc010dma.2_Missense_Mutation_p.K118E|B4GALT6_uc010dmb.2_Missense_Mutation_p.K157E	NM_004775	NP_004766	Q9UBX8	B4GT6_HUMAN	beta-1,4-galactosyltransferase 6	157	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			TACCTCACCTTCCATCTGGGT	0.378													C	29225320	C	C	29225320	3	2	29	1	0	0	0	0	1	0	0	0	1275	1792	62	4	703	4	B4GALT6	18	29225320	Missense_Mutation	SNP	T	TCGA-06-0165-01A-01D-1491-08		29225320	48851928	8	1872											
TNFRSF25	8718	broad.mit.edu	37	chr1	6522120	6522120	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gcagagcgcctcctgggtctCggggtagccaggggtccagc	17	13	1	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr1:6522120C>A	uc001ane.2	-	9	947	c.859G>T	c.(859-861)GAG>TAG	p.E287*	TNFRSF25_uc001ana.2_Nonsense_Mutation_p.E104*|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_Nonsense_Mutation_p.E60*|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Nonsense_Mutation_p.E250*|TNFRSF25_uc001ang.2_Nonsense_Mutation_p.E242*|TNFRSF25_uc001anh.2_Nonsense_Mutation_p.E296*	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	287	Cytoplasmic (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		TCCTGGGTCTCGGGGTAGCCA	0.627													A	6522120	A	A	6522120	4	1	30	1	0	0	0	0	0	1	0	0	16293	893	31	5	402	5	TNFRSF25	1	6522120	Nonsense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08		6522120	242728501	1	1873											
LPHN2	23266	broad.mit.edu	37	chr1	82456163	82456163	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aacagctactcgctgcacaaGggtgactataatgacagcgt	10	10	0	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr1:82456163G>C	uc001dit.3	+	21	3727	c.3546G>C	c.(3544-3546)AAG>AAC	p.K1182N	LPHN2_uc001dis.2_Missense_Mutation_p.K162N|LPHN2_uc001diu.2_Missense_Mutation_p.K1182N|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_3'UTR|LPHN2_uc001diw.2_Missense_Mutation_p.K809N	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1238	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CGCTGCACAAGGGTGACTATA	0.413													C	82456163	C	C	82456163	3	2	30	1	0	0	0	0	1	0	0	0	8916	991	35	5	3620	5	LPHN2	1	82456163	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	75934043	82456163	166794458	2	1874											
PEX19	5824	broad.mit.edu	37	chr1	160254853	160254853	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgggctcttactttccagaAgctcctccaattccctgtcc	6	15	1	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr1:160254853A>G	uc001fvs.2	-	1	89	c.62T>C	c.(61-63)CTT>CCT	p.L21P	DCAF8_uc010pjc.1_5'UTR|PEX19_uc010pje.1_RNA|PEX19_uc001fvt.2_5'UTR	NM_002857	NP_002848	P40855	PEX19_HUMAN	peroxisomal biogenesis factor 19 isoform a	21	Necessary for PEX19 function on peroxisome biogenesis.|Docking to the peroxisome membrane and binding to PEX3.				peroxisome membrane biogenesis|peroxisome organization|protein targeting to peroxisome|transmembrane transport	brush border membrane|cytosol|integral to membrane|nucleus|peroxisomal membrane	protein binding|protein N-terminus binding				0	all_cancers(52;1.27e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACTTTCCAGAAGCTCCTCCAA	0.597													G	160254853	G	G	160254853	3	3	30	1	0	0	0	0	1	0	0	0	11744	72	3	4	869	4	PEX19	1	160254853	Missense_Mutation	SNP	A	TCGA-06-0166-01A-01D-1491-08	77798690	160254853	88995768	3	1875											
ARID4B	51742	broad.mit.edu	37	chr1	235345301	235345301	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctagttctacactgggtgaaCaactctcctcttcagccaca	6	14	4	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr1:235345301C>T	uc001hwq.2	-	20	3431	c.2933G>A	c.(2932-2934)TGT>TAT	p.C978Y	ARID4B_uc001hwr.2_Missense_Mutation_p.C892Y|ARID4B_uc001hws.3_Missense_Mutation_p.C892Y|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.C659Y	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	978					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			ACTGGGTGAACAACTCTCCTC	0.493													T	235345301	T	T	235345301	3	4	30	1	0	0	0	0	1	0	0	0	920	478	17	3	1025	3	ARID4B	1	235345301	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	75090448	235345301	13905320	4	1876											
OR6F1	343169	broad.mit.edu	37	chr1	247875180	247875180	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctctcttacttccttattaCgaagcgtatagatgaagggg	9	8	2	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr1:247875180C>T	uc001idj.1	-	1	878	c.878G>A	c.(877-879)CGT>CAT	p.R293H		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TTCCTTATTACGAAGCGTATA	0.438													T	247875180	T	T	247875180	3	4	30	1	0	0	0	0	1	0	0	0	11201	536	19	1	52	1	OR6F1	1	247875180	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	12529879	247875180	1375441	5	1877											
DYNC2LI1	51626	broad.mit.edu	37	chr2	44023908	44023908	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaagacacttcgatttgttGcacattattatggagcatca	8	8	1	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr2:44023908G>A	uc002rtk.2	+	8	724	c.628G>A	c.(628-630)GCA>ACA	p.A210T	DYNC2LI1_uc002rtj.2_Missense_Mutation_p.A210T|DYNC2LI1_uc002rtl.2_Missense_Mutation_p.A211T|DYNC2LI1_uc010ynz.1_Missense_Mutation_p.A84T	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	210						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCGATTTGTTGCACATTATTA	0.343													A	44023908	A	A	44023908	3	1	30	1	0	0	0	0	1	0	0	0	4847	1319	46	3	757	3	DYNC2LI1	2	44023908	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08		44023908	199175465	6	1878											
ZRANB3	84083	broad.mit.edu	37	chr2	135960424	135960424	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctttgtgacagactgtgcagAgagtctgcaggttgtccagg	14	8	1	3			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr2:135960424A>G	uc002tum.2	-	20	3236	c.3119T>C	c.(3118-3120)CTC>CCC	p.L1040P	ZRANB3_uc002tuk.2_Missense_Mutation_p.L583P|ZRANB3_uc002tul.2_Missense_Mutation_p.L1038P	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	1040						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		GACTGTGCAGAGAGTCTGCAG	0.478													G	135960424	G	G	135960424	3	3	30	1	0	0	0	0	1	0	0	0	18221	304	11	4	128	4	ZRANB3	2	135960424	Missense_Mutation	SNP	A	TCGA-06-0166-01A-01D-1491-08	91936516	135960424	107238949	7	1879											
NUP210	23225	broad.mit.edu	37	chr3	13379344	13379344	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggtcccctcacctgggtgCccgtcctcatccgcatgatg	11	16	2	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr3:13379344C>T	uc003bxv.1	-	26	3628	c.3545G>A	c.(3544-3546)GGC>GAC	p.G1182D		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1182	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CACCTGGGTGCCCGTCCTCAT	0.627													T	13379344	T	T	13379344	3	4	30	1	0	0	0	0	1	0	0	0	10760	739	26	3	2178	3	NUP210	3	13379344	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08		13379344	184643086	8	1880											
XCR1	2829	broad.mit.edu	37	chr3	46063343	46063343	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagtataggacagtggtggCgagggtagcaaagacccagg	17	7	0	1	rs140218706		TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr3:46063343C>T	uc003cpe.2	-	3	321	c.97G>A	c.(97-99)GCC>ACC	p.A33T	uc003cpd.1_5'Flank|XCR1_uc003cpf.2_Missense_Mutation_p.A33T	NM_005283	NP_005274	P46094	XCR1_HUMAN	XC chemokine receptor 1	33	Helical; Name=1; (Potential).				chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		ACAGTGGTGGCGAGGGTAGCA	0.567													T	46063343	T	T	46063343	3	4	30	1	0	0	0	0	1	0	0	0	17422	768	27	1	908	1	XCR1	3	46063343	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	32683999	46063343	151959087	9	1881											
CP	1356	broad.mit.edu	37	chr3	148895735	148895735	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cccacgtgcattgtgaggccTtgtaggtttccaaacattct	9	11	1	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr3:148895735T>G	uc003ewy.3	-	17	3163	c.2910A>C	c.(2908-2910)CAA>CAC	p.Q970H	CP_uc011bnr.1_RNA|CP_uc003eww.3_Missense_Mutation_p.Q122H|CP_uc003ewx.3_Missense_Mutation_p.Q751H|CP_uc003ewz.2_Missense_Mutation_p.Q970H	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	970	F5/8 type A 3.|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TTGTGAGGCCTTGTAGGTTTC	0.378													G	148895735	G	G	148895735	3	3	30	1	0	0	0	0	1	0	0	0	3787	1606	56	5	299	5	CP	3	148895735	Missense_Mutation	SNP	T	TCGA-06-0166-01A-01D-1491-08	102832392	148895735	49126695	10	1882											
MECOM	2122	broad.mit.edu	37	chr3	169099085	169099085	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccatattcctagtcctgcccCaggcatatttgactctcgaa	6	14	1	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr3:169099085C>A	uc011bpj.1	-	2	668	c.265G>T	c.(265-267)GGG>TGG	p.G89W	MECOM_uc003ffl.2_Missense_Mutation_p.G61W|MECOM_uc011bpk.1_Intron|MECOM_uc010hwn.2_Missense_Mutation_p.G89W|MECOM_uc011bpl.1_Missense_Mutation_p.G89W	NM_004991	NP_004982	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform c	Error:Variant_position_missing_in_Q03112_after_alignment					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						AGTCCTGCCCCAGGCATATTT	0.473													A	169099085	A	A	169099085	3	1	30	1	0	0	0	0	1	0	0	0	9422	594	21	5	3528	5	MECOM	3	169099085	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	20203350	169099085	28923345	11	1883											
PIK3CA	5290	broad.mit.edu	37	chr3	178916641	178916661	+	In_Frame_Del	DEL	CTGTGGGGCATCCACTTGATG	-	-													cacgaccatcatcaggtgaaCtgtggggcatccacttgatg							TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr3:178916641_178916661delCTGTGGGGCATCCACTTGATG	uc003fjk.2	+	2	185_205	c.28_48delCTGTGGGGCATCCACTTGATG	c.(28-48)CTGTGGGGCATCCACTTGATGdel	p.LWGIHLM10del		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	10_16					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G12D(2)|p.L10_M16del(1)|p.L15_V22>PM(1)|p.E9_R19del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATCAGGTGAACTGTGGGGCATCCACTTGATGCCCCCAAGAA	0.394		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			-	178916661	-	-	178916641	7	5	30	1	0	1	0	1	0	0	0	0	11913	564	20	0	30	0	PIK3CA	3	178916641	In_Frame_Del	DEL	CTGTGGGGCATCCACTTGATG	TCGA-06-0166-01A-01D-1491-08	9817556	178916641	19105789	12	1884											
LIMCH1	22998	broad.mit.edu	37	chr4	41652554	41652554	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagtgcacgggtctccactgGagctgaaacaagacaacggt	13	10	1	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr4:41652554G>A	uc003gvu.3	+	13	1864	c.1810G>A	c.(1810-1812)GAG>AAG	p.E604K	LIMCH1_uc003gvv.3_Missense_Mutation_p.E604K|LIMCH1_uc003gvw.3_Missense_Mutation_p.E604K|LIMCH1_uc003gvx.3_Missense_Mutation_p.E592K|LIMCH1_uc003gwe.3_Missense_Mutation_p.E604K|LIMCH1_uc003gvy.3_Missense_Mutation_p.E433K|LIMCH1_uc003gwa.3_Missense_Mutation_p.E445K|LIMCH1_uc003gvz.3_Missense_Mutation_p.E989K|LIMCH1_uc011byu.1_Missense_Mutation_p.E438K|LIMCH1_uc003gwc.3_Missense_Mutation_p.E450K|LIMCH1_uc003gwd.3_Missense_Mutation_p.E438K|LIMCH1_uc011byv.1_Missense_Mutation_p.E355K	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	604					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						GTCTCCACTGGAGCTGAAACA	0.527													A	41652554	A	A	41652554	3	1	30	1	0	0	0	0	1	0	0	0	8797	1175	41	3	1888	3	LIMCH1	4	41652554	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08		41652554	149501722	13	1885											
NPY2R	4887	broad.mit.edu	37	chr4	156135822	156135822	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttcctacactcgcatttggaGtaaattgaagaaccatgtca	7	9	1	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr4:156135822G>C	uc003ioq.2	+	2	1226	c.731G>C	c.(730-732)AGT>ACT	p.S244T	NPY2R_uc003ior.2_Missense_Mutation_p.S244T	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	244	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				CGCATTTGGAGTAAATTGAAG	0.433													C	156135822	C	C	156135822	3	2	30	1	0	0	0	0	1	0	0	0	10609	1029	36	5	733	5	NPY2R	4	156135822	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	114483268	156135822	35018454	14	1886											
FTMT	94033	broad.mit.edu	37	chr5	121187974	121187974	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attacttctcccgggatgacGtggccttgaacaacttctcc	8	13	2	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr5:121187974G>A	uc003kss.2	+	1	325	c.316G>A	c.(316-318)GTG>ATG	p.V106M		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	106	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		CCGGGATGACGTGGCCTTGAA	0.592													A	121187974	A	A	121187974	3	1	30	1	0	0	0	0	1	0	0	0	6085	1145	40	1	318	1	FTMT	5	121187974	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08		121187974	59727286	15	1887											
FCHSD1	89848	broad.mit.edu	37	chr5	141029038	141029038	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atcggtcagacgcctggagtCgggtttggcccccagccacg	14	14	1	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr5:141029038C>T	uc003llk.2	-	5	350	c.299G>A	c.(298-300)CGA>CAA	p.R100Q	FCHSD1_uc010jgg.2_5'Flank|FCHSD1_uc003llj.2_RNA	NM_033449	NP_258260	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	100									FCHSD1/BRAF(2)	skin(2)|ovary(1)|central_nervous_system(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCTGGAGTCGGGTTTGGCC	0.637													T	141029038	T	T	141029038	3	4	30	1	0	0	0	0	1	0	0	0	5789	884	31	2	1837	2	FCHSD1	5	141029038	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	19841064	141029038	39886222	16	1888											
PCLO	27445	broad.mit.edu	37	chr7	82595090	82595090	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agtaaaatttaacttactgtTttttctttcccaggttccac	4	9	1	0			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr7:82595090T>A	uc003uhx.2	-	4	4303	c.4014A>T	c.(4012-4014)AAA>AAT	p.K1338N	PCLO_uc003uhv.2_Missense_Mutation_p.K1338N	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AACTTACTGTTTTTTCTTTCC	0.338													A	82595090	A	A	82595090	3	1	30	1	0	0	0	0	1	0	0	0	11583	1838	64	5	11519	5	PCLO	7	82595090	Missense_Mutation	SNP	T	TCGA-06-0166-01A-01D-1491-08		82595090	76543573	17	1889											
DYNC1I1	1780	broad.mit.edu	37	chr7	95457400	95457400	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggacacagacccctcagtgCtccagctgcagtcagactca	10	15	3	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr7:95457400C>T	uc003uoc.3	+	5	674	c.397C>T	c.(397-399)CTC>TTC	p.L133F	DYNC1I1_uc003uod.3_Missense_Mutation_p.L116F|DYNC1I1_uc003uob.2_Intron|DYNC1I1_uc003uoe.3_Intron|DYNC1I1_uc010lfl.2_Missense_Mutation_p.L122F	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	133					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CCCCTCAGTGCTCCAGCTGCA	0.443													T	95457400	T	T	95457400	3	4	30	1	0	0	0	0	1	0	0	0	4842	797	28	3	411	3	DYNC1I1	7	95457400	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	12862310	95457400	63681263	18	1890											
AP3M2	10947	broad.mit.edu	37	chr8	42024775	42024776	+	Frame_Shift_Ins	INS	-	GT	GT													taacggtgggacccaagcagINSacgatggggaagaccattga							TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr8:42024775_42024776insGT	uc003xop.2	+	8	1188_1189	c.897_898insGT	c.(895-900)CAGACGfs	p.Q299fs	AP3M2_uc003xoo.2_Frame_Shift_Ins_p.Q299fs|AP3M2_uc010lxe.2_Intron	NM_001134296	NP_001127768	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	299_300	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus					0	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			GACCCAAGCAGACGATGGGGAA	0.515													GT	42024776	GT	GT	42024775	7	5	30	1	0	1	1	0	0	0	0	0	748	933	33	0	919	0	AP3M2	8	42024775	Frame_Shift_Ins	INS	-	TCGA-06-0166-01A-01D-1491-08		42024775	104339247	19	1891											
ST18	9705	broad.mit.edu	37	chr8	53073986	53073986	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactgtttgtatgagagggcGtttaccgaaaacttgggcat	12	7	0	1	rs2303460	byFrequency	TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr8:53073986G>A	uc003xqz.2	-	9	1699	c.1543C>T	c.(1543-1545)CGC>TGC	p.R515C	ST18_uc011ldq.1_Missense_Mutation_p.R162C|ST18_uc011ldr.1_Missense_Mutation_p.R480C|ST18_uc011lds.1_Missense_Mutation_p.R420C|ST18_uc003xra.2_Missense_Mutation_p.R515C|ST18_uc003xrb.2_Missense_Mutation_p.R515C	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	515						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ATGAGAGGGCGTTTACCGAAA	0.433													A	53073986	A	A	53073986	3	1	30	1	0	0	0	0	1	0	0	0	15211	1145	40	1	1652	1	ST18	8	53073986	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	11049211	53073986	93290036	20	1892											
DCAF13	25879	broad.mit.edu	37	chr8	104427337	104427338	+	Frame_Shift_Ins	INS	-	G	G													gccggagactctagtactgaINSgggggcaagaacggggcaca							TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr8:104427337_104427338insG	uc003yln.2	+	1	396_397	c.119_120insG	c.(118-120)GAGfs	p.E40fs	SLC25A32_uc003yll.2_5'UTR|SLC25A32_uc011lhr.1_5'UTR|DCAF13_uc003ylm.1_5'UTR|DCAF13_uc003ylo.2_5'UTR	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	WD repeats and SOF1 domain containing	Error:Variant_position_missing_in_Q9NV06_after_alignment					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1						TCTAGTACTGAGGGGGCAAGAA	0.663													G	104427338	G	G	104427337	7	5	30	1	0	1	1	0	0	0	0	0	4266	304	11	0	121	0	DCAF13	8	104427337	Frame_Shift_Ins	INS	-	TCGA-06-0166-01A-01D-1491-08	51353351	104427337	41936685	21	1893											
ASAP1	50807	broad.mit.edu	37	chr8	131124496	131124496	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tcctggcagtgccagcttgtCctggggggagatgctggagg	18	9	0	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr8:131124496C>G	uc003yta.1	-	23	2273	c.2245G>C	c.(2245-2247)GAC>CAC	p.D749H	ASAP1_uc003ysz.1_Missense_Mutation_p.D560H|ASAP1_uc011liw.1_Missense_Mutation_p.D742H	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	749					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						GCCAGCTTGTCCTGGGGGGAG	0.542													G	131124496	G	G	131124496	3	3	30	1	0	0	0	0	1	0	0	0	1010	855	30	5	1172	5	ASAP1	8	131124496	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	26697159	131124496	15239526	22	1894											
FAM75C1	441452	broad.mit.edu	37	chr9	90537612	90537612	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctatgtgacctcatgtcagcCagaaggagtaacatggggca	12	9	2	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr9:90537612C>T	uc010mqi.2	+	4	2819	c.2790C>T	c.(2788-2790)GCC>GCT	p.A930A	FAM75C1_uc004apq.3_Silent_p.A913A	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						TCATGTCAGCCAGAAGGAGTA	0.547													T	90537612	T	T	90537612	2	4	30	1	0	0	0	0	0	0	0	1	5623	581	21	3		3	FAM75C1	9	90537612	Silent	SNP	C	TCGA-06-0166-01A-01D-1491-08		90537612	50675819	23	1895											
ZNF618	114991	broad.mit.edu	37	chr9	116750662	116750662	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcccagagccagtgccagccGaggcctcgctgagtgccgag	15	15	0	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr9:116750662G>A	uc004bid.2	+	3	238	c.139G>A	c.(139-141)GAG>AAG	p.E47K	ZNF618_uc004bib.1_Missense_Mutation_p.E47K|ZNF618_uc004bic.2_Missense_Mutation_p.E47K|ZNF618_uc011lxi.1_Missense_Mutation_p.E47K|ZNF618_uc011lxj.1_Missense_Mutation_p.E47K	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGTGCCAGCCGAGGCCTCGCT	0.602													A	116750662	A	A	116750662	3	1	30	1	0	0	0	0	1	0	0	0	18039	1059	37	2	149	2	ZNF618	9	116750662	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	26213050	116750662	24462769	24	1896											
OR5C1	392391	broad.mit.edu	37	chr9	125551633	125551633	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tctctatacaacagctatgtCgcagcgtctatgcctggcct	8	13	2	0			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr9:125551633C>T	uc011lzd.1	+	1	422	c.422C>T	c.(421-423)TCG>TTG	p.S141L		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	141	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						ACAGCTATGTCGCAGCGTCTA	0.572													T	125551633	T	T	125551633	3	4	30	1	0	0	0	0	1	0	0	0	11153	893	31	2	424	2	OR5C1	9	125551633	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	8800971	125551633	15661798	25	1897											
BMI1	648	broad.mit.edu	37	chr10	22615862	22615862	+	Nonsense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tacctggagaccagcaagtaTtgtcctatttgtgatgtcca	9	9	0	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr10:22615862T>G	uc001irh.2	+	3	795	c.156T>G	c.(154-156)TAT>TAG	p.Y52*	BMI1_uc009xkg.2_Nonsense_Mutation_p.Y195*	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	52	RING-type.				hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						CCAGCAAGTATTGTCCTATTT	0.343													G	22615862	G	G	22615862	4	3	30	1	0	0	0	0	0	1	0	0	1455	1500	52	5	162	5	BMI1	10	22615862	Nonsense_Mutation	SNP	T	TCGA-06-0166-01A-01D-1491-08		22615862	112918885	26	1898											
C10orf71	118461	broad.mit.edu	37	chr10	50531485	50531485	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	acacagctggaaccgtcccaGaaagcaaagctcccaagcac	8	15	0	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr10:50531485G>A	uc010qgp.1	+	3	1234	c.895G>A	c.(895-897)GAA>AAA	p.E299K		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	299											0						AACCGTCCCAGAAAGCAAAGC	0.542													A	50531485	A	A	50531485	3	1	30	1	0	0	0	0	1	0	0	0	1614	943	33	3	897	3	C10orf71	10	50531485	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	27915623	50531485	85003262	27	1899											
PTEN	5728	broad.mit.edu	37	chr10	89711882	89711882	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttctgtccaccagggagtaaCtattcccagtcagaggcgct	10	12	2	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr10:89711882C>G	uc001kfb.2	+	7	1531	c.500C>G	c.(499-501)ACT>AGT	p.T167S		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	167	Phosphatase tensin-type.		T -> P (in breast cancer; severely reduced protein phosphatase activity).	T->A,D: 60% reduction in phosphatase activity towards PtdIns(3,4,5)P3.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.T167A(4)|p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.V166fs*10(1)|p.T167I(1)|p.G165_K342del(1)|p.G165_*404del(1)|p.T167S(1)|p.T167P(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CAGGGAGTAACTATTCCCAGT	0.368		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			G	89711882	G	G	89711882	3	3	30	1	0	0	0	0	1	0	0	0	12738	565	20	5	522	5	PTEN	10	89711882	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	39180397	89711882	45822865	28	1900											
KNDC1	85442	broad.mit.edu	37	chr10	135012314	135012314	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctccaccccaggccccagcaAaccagccagagggggcctca	10	19	1	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr10:135012314A>C	uc001llz.1	+	14	2303	c.2302A>C	c.(2302-2304)AAC>CAC	p.N768H	KNDC1_uc001lma.1_Missense_Mutation_p.N703H|KNDC1_uc001lmb.1_Missense_Mutation_p.N180H	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	768	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGCCCCAGCAAACCAGCCAGA	0.731													C	135012314	C	C	135012314	3	2	30	1	0	0	0	0	1	0	0	0	8426	14	1	5	2356	5	KNDC1	10	135012314	Missense_Mutation	SNP	A	TCGA-06-0166-01A-01D-1491-08	45300432	135012314	522433	29	1901											
MYOD1	4654	broad.mit.edu	37	chr11	17741852	17741852	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acgccgcgccccctggcgccGcagccgccttctatgcgccg	12	21	1	0	rs143600911		TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr11:17741852G>T	uc001mni.2	+	1	743	c.523G>T	c.(523-525)GCA>TCA	p.A175S		NM_002478	NP_002469	P15172	MYOD1_HUMAN	myogenic differentiation 1	175					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|ovary(1)	3						CCCTGGCGCCGCAGCCGCCTT	0.577													T	17741852	T	T	17741852	3	4	30	1	0	0	0	0	1	0	0	0	10088	1087	38	5	525	5	MYOD1	11	17741852	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08		17741852	117264664	30	1902											
TMEM132D	121256	broad.mit.edu	37	chr12	129558863	129558863	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	actcatcccttcctgctcctCgaagggaacctgtttgtgtc	8	14	1	0			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr12:129558863C>A	uc009zyl.1	-	9	3185	c.2857G>T	c.(2857-2859)GAG>TAG	p.E953*	TMEM132D_uc001uia.2_Nonsense_Mutation_p.E491*	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	953	Cytoplasmic (Potential).					integral to membrane		p.E953*(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCCTGCTCCTCGAAGGGAACC	0.458													A	129558863	A	A	129558863	4	1	30	1	0	0	0	0	0	1	0	0	16044	893	31	5	446	5	TMEM132D	12	129558863	Nonsense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08		129558863	4293032	31	1903											
NALCN	259232	broad.mit.edu	37	chr13	101795440	101795440	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcagatcttactttttggtcGatgtatttgttgtcctcaat	8	7	2	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr13:101795440G>A	uc001vox.1	-	17	2298	c.2109C>T	c.(2107-2109)ATC>ATT	p.I703I	NALCN_uc001voy.2_Silent_p.I418I	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	703	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTTTTTGGTCGATGTATTTGT	0.468													A	101795440	A	A	101795440	2	1	30	1	0	0	0	0	0	0	0	1	10148	1048	37	2		2	NALCN	13	101795440	Silent	SNP	G	TCGA-06-0166-01A-01D-1491-08		101795440	13374438	32	1904											
CDKL1	8814	broad.mit.edu	37	chr14	50862534	50862534	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccctgtttctacatttgaaaAcaactccataggatccttct	4	12	2	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr14:50862534A>G	uc010anu.1	-	5	623	c.623T>C	c.(622-624)GTT>GCT	p.V208A	CDKL1_uc001wxz.2_Missense_Mutation_p.V19A	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	18	ATP (By similarity).|Protein kinase.					cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					ACATTTGAAAACAACTCCATA	0.358													G	50862534	G	G	50862534	3	3	30	1	0	0	0	0	1	0	0	0	3153	43	2	4	1056	4	CDKL1	14	50862534	Missense_Mutation	SNP	A	TCGA-06-0166-01A-01D-1491-08		50862534	56487006	33	1905											
KCNH5	27133	broad.mit.edu	37	chr14	63447847	63447847	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attataaggaaccataatggCggtgtagaaggtaagaatta	11	3	0	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr14:63447847C>T	uc001xfx.2	-	6	736	c.685G>A	c.(685-687)GCC>ACC	p.A229T	KCNH5_uc001xfy.2_Missense_Mutation_p.A229T|KCNH5_uc001xfz.1_Missense_Mutation_p.A171T|KCNH5_uc001xga.2_Missense_Mutation_p.A171T	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	229	Helical; Name=Segment S1; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACCATAATGGCGGTGTAGAAG	0.383													T	63447847	T	T	63447847	3	4	30	1	0	0	0	0	1	0	0	0	8035	768	27	1	2339	1	KCNH5	14	63447847	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	12585313	63447847	43901693	34	1906											
HERC2	8924	broad.mit.edu	37	chr15	28460793	28460793	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagcgaggtggcagtgaAgggtgcgtgcccttccacga	16	11	0	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr15:28460793A>G	uc001zbj.2	-	39	6290	c.6184T>C	c.(6184-6186)TTC>CTC	p.F2062L		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2062					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GTGGCAGTGAAGGGTGCGTGC	0.607													G	28460793	G	G	28460793	3	3	30	1	0	0	0	0	1	0	0	0	7058	72	3	4	8540	4	HERC2	15	28460793	Missense_Mutation	SNP	A	TCGA-06-0166-01A-01D-1491-08		28460793	74070599	35	1907											
FRMD5	84978	broad.mit.edu	37	chr15	44181021	44181021	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcacctctttctgacttaCgtataaatagaaagtctttc	4	10	4	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr15:44181021C>T	uc001ztl.2	-	9	955	c.778G>A	c.(778-780)GTA>ATA	p.V260I	FRMD5_uc001ztj.1_5'UTR|FRMD5_uc001ztk.1_Splice_Site_p.Y170_splice|FRMD5_uc001ztm.2_5'UTR|FRMD5_uc001ztn.2_Missense_Mutation_p.V26I	NM_032892	NP_116281	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5 isoform 2	260	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		TTCTGACTTACGTATAAATAG	0.498													T	44181021	T	T	44181021	3	4	30	1	0	0	0	0	1	0	0	0	6053	536	19	1	958	1	FRMD5	15	44181021	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	15720228	44181021	58350371	36	1908											
SLTM	79811	broad.mit.edu	37	chr15	59186379	59186379	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcatttctttcttagagGgatcaccttttacctgaaag	6	9	5	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr15:59186379G>A	uc002afp.2	-	11	1479	c.1391C>T	c.(1390-1392)CCC>CTC	p.P464L	SLTM_uc002afn.2_Missense_Mutation_p.P33L|SLTM_uc002afo.2_Missense_Mutation_p.P446L|SLTM_uc002afq.2_Missense_Mutation_p.P33L|SLTM_uc010bgd.2_Missense_Mutation_p.P33L	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	464					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TTTCTTAGAGGGATCACCTTT	0.318													A	59186379	A	A	59186379	3	1	30	1	0	0	0	0	1	0	0	0	14754	1232	43	3	1757	3	SLTM	15	59186379	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	15005358	59186379	43345013	37	1909											
GCNT3	9245	broad.mit.edu	37	chr15	59911701	59911701	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aggtagatgataatgctcttCagtgcttagaagaataccta	9	6	2	4			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr15:59911701C>T	uc002age.2	+	3	1713	c.1264C>T	c.(1264-1266)CAG>TAG	p.Q422*	GCNT3_uc002agd.2_Nonsense_Mutation_p.Q422*	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	422	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						TAATGCTCTTCAGTGCTTAGA	0.458													T	59911701	T	T	59911701	4	4	30	1	0	0	0	0	0	1	0	0	6302	827	29	3	1266	3	GCNT3	15	59911701	Nonsense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	725322	59911701	42619691	38	1910											
RASGRF1	5923	broad.mit.edu	37	chr15	79320175	79320175	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtttttccggatgttctccGtctcacttacttcatcgtgc	8	12	3	0			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr15:79320175G>A	uc002beq.2	-	9	1664	c.1289C>T	c.(1288-1290)ACG>ATG	p.T430M	RASGRF1_uc002bep.2_Missense_Mutation_p.T430M|RASGRF1_uc010blm.1_Missense_Mutation_p.T352M|RASGRF1_uc002ber.3_Missense_Mutation_p.T430M	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	430					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GATGTTCTCCGTCTCACTTAC	0.547													A	79320175	A	A	79320175	3	1	30	1	0	0	0	0	1	0	0	0	13072	1145	40	1	2612	1	RASGRF1	15	79320175	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	19408474	79320175	23211217	39	1911											
RPL3L	6123	broad.mit.edu	37	chr16	2002950	2002950	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcttgaagctccggagacctCgaggggtggccacgtagccc	14	13	1	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr16:2002950C>T	uc002cnh.2	-	3	337	c.290G>A	c.(289-291)CGA>CAA	p.R97Q		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	97					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						CCGGAGACCTCGAGGGGTGGC	0.607													T	2002950	T	T	2002950	3	4	30	1	0	0	0	0	1	0	0	0	13594	884	31	2	965	2	RPL3L	16	2002950	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08		2002950	88351803	40	1912											
ATF7IP2	80063	broad.mit.edu	37	chr16	10524503	10524503	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagtccagatagaagtaaacGgaagatattaaaagccaaaa	8	5	0	3			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr16:10524503G>A	uc002czu.2	+	3	253	c.26G>A	c.(25-27)CGG>CAG	p.R9Q	ATF7IP2_uc002czv.2_Missense_Mutation_p.R9Q|ATF7IP2_uc010uyo.1_RNA|ATF7IP2_uc010uyp.1_Intron|ATF7IP2_uc002czw.2_Missense_Mutation_p.R9Q|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGAAGTAAACGGAAGATATTA	0.348													A	10524503	A	A	10524503	3	1	30	1	0	0	0	0	1	0	0	0	1088	1116	39	2	28	2	ATF7IP2	16	10524503	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	8521553	10524503	79830250	41	1913											
ABCC1	4363	broad.mit.edu	37	chr16	16218658	16218658	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcgcaggtggctggccgtGcggctggagtgtgtgggcaa	21	8	0	0			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr16:16218658G>A	uc010bvi.2	+	25	3778	c.3603G>A	c.(3601-3603)GTG>GTA	p.V1201V	ABCC1_uc010bvj.2_Silent_p.V1142V|ABCC1_uc010bvk.2_Silent_p.V1145V|ABCC1_uc010bvl.2_Silent_p.V1201V|ABCC1_uc010bvm.2_Silent_p.V1086V|ABCC1_uc002del.3_Silent_p.V1095V	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1201	Cytoplasmic.|ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGCTGGCCGTGCGGCTGGAGT	0.592													A	16218658	A	A	16218658	2	1	30	1	0	0	0	0	0	0	0	1	49	1306	46	3		3	ABCC1	16	16218658	Silent	SNP	G	TCGA-06-0166-01A-01D-1491-08	5694155	16218658	74136095	42	1914											
CLEC3A	10143	broad.mit.edu	37	chr16	78064579	78064579	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaagtttgttgacgtcaaCggaatcgctatctccttcct	9	11	2	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr16:78064579C>T	uc002ffh.3	+	3	516	c.435C>T	c.(433-435)AAC>AAT	p.N145N		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	145	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						TTGACGTCAACGGAATCGCTA	0.527													T	78064579	T	T	78064579	2	4	30	1	0	0	0	0	0	0	0	1	3510	535	19	1		1	CLEC3A	16	78064579	Silent	SNP	C	TCGA-06-0166-01A-01D-1491-08	61845921	78064579	12290174	43	1915											
MYH1	4619	broad.mit.edu	37	chr17	10415407	10415407	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttacctgctgcacagtttgaCctttggtgacatactcattg	8	10	1	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr17:10415407C>A	uc002gmo.2	-	13	1344	c.1250G>T	c.(1249-1251)GGT>GTT	p.G417V	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	417	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CACAGTTTGACCTTTGGTGAC	0.463													A	10415407	A	A	10415407	3	1	30	1	0	0	0	0	1	0	0	0	10029	507	18	5	4681	5	MYH1	17	10415407	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08		10415407	70779803	44	1916											
MYO19	80179	broad.mit.edu	37	chr17	34864958	34864958	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgctgttgatcactgataCcagccagtcaaacaacctgt	8	12	2	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr17:34864958C>T	uc010wcy.1	-	15	2166	c.1174G>A	c.(1174-1176)GTA>ATA	p.V392I	MYO19_uc002hmw.2_Missense_Mutation_p.V392I|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	392	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ATCACTGATACCAGCCAGTCA	0.537													T	34864958	T	T	34864958	3	4	30	1	0	0	0	0	1	0	0	0	10067	507	18	3	1790	3	MYO19	17	34864958	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	24449551	34864958	46330252	45	1917											
MPP3	4356	broad.mit.edu	37	chr17	41898381	41898381	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcctcctggcaagggatggCccggtcctcccgagggttgt	15	14	0	0			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr17:41898381C>T	uc002iei.3	-	11	896	c.730G>A	c.(730-732)GCC>ACC	p.A244T	MPP3_uc002ieh.2_Missense_Mutation_p.A269T|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Missense_Mutation_p.A244T|MPP3_uc010wik.1_Missense_Mutation_p.A269T	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	244	SH3.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		CAAGGGATGGCCCGGTCCTCC	0.677													T	41898381	T	T	41898381	3	4	30	1	0	0	0	0	1	0	0	0	9735	739	26	3	1067	3	MPP3	17	41898381	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	7033423	41898381	39296829	46	1918											
SPIRE1	56907	broad.mit.edu	37	chr18	12496095	12496095	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taaccgagggggaatatcacCattcacctaaaaggagacaa	9	9	2	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr18:12496095C>A	uc002kre.2	-	7	1026	c.979G>T	c.(979-981)GGT>TGT	p.G327C	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Missense_Mutation_p.G207C|SPIRE1_uc010wzx.1_Missense_Mutation_p.G130C|SPIRE1_uc010wzy.1_Missense_Mutation_p.G327C	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	327						cytoskeleton|perinuclear region of cytoplasm	actin binding				0						GGAATATCACCATTCACCTAA	0.358													A	12496095	A	A	12496095	3	1	30	1	0	0	0	0	1	0	0	0	15070	594	21	5	1335	5	SPIRE1	18	12496095	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08		12496095	65581153	47	1919											
ILF3	3609	broad.mit.edu	37	chr19	10798360	10798360	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgggggcgggggcggatccGactacaactacgagagcaaa	16	11	0	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr19:10798360G>A	uc002mpn.2	+	18	2715	c.2398G>A	c.(2398-2400)GAC>AAC	p.D800N	ILF3_uc002mpo.2_Missense_Mutation_p.D804N|ILF3_uc002mpq.2_Silent_p.P102P	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	800	Interaction with PRMT1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GGGCGGATCCGACTACAACTA	0.617													A	10798360	A	A	10798360	3	1	30	1	0	0	0	0	1	0	0	0	7712	1058	37	2	2548	2	ILF3	19	10798360	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08		10798360	48330623	48	1920											
LDLR	3949	broad.mit.edu	37	chr19	11233883	11233883	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agtggccacccaggagacatCcaccgtcaggctaaaggtca	11	13	2	1			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr19:11233883C>A	uc002mqk.3	+	15	2342	c.2174C>A	c.(2173-2175)TCC>TAC	p.S725Y	LDLR_uc010xlk.1_Missense_Mutation_p.S725Y|LDLR_uc010xll.1_Missense_Mutation_p.S684Y|LDLR_uc010xlm.1_Missense_Mutation_p.S578Y|LDLR_uc010xln.1_Missense_Mutation_p.S547Y|LDLR_uc010xlo.1_Missense_Mutation_p.S557Y	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	725	Clustered O-linked oligosaccharides.|Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CAGGAGACATCCACCGTCAGG	0.607													A	11233883	A	A	11233883	3	1	30	1	0	0	0	0	1	0	0	0	8704	855	30	5	2232	5	LDLR	19	11233883	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	435523	11233883	47895100	49	1921											
FBL	2091	broad.mit.edu	37	chr19	40328442	40328442	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaagttaatgaggtcacgGccagagcggtgggagaactc	15	9	1	3			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr19:40328442G>A	uc002omn.2	-	6	705	c.591C>T	c.(589-591)GGC>GGT	p.G197G	FBL_uc002omm.1_Silent_p.G111G|FBL_uc002omo.2_Silent_p.G196G	NM_001436	NP_001427	P22087	FBRL_HUMAN	fibrillarin	197					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			ovary(1)	1	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		TGAGGTCACGGCCAGAGCGGT	0.413													A	40328442	A	A	40328442	2	1	30	1	0	0	0	0	0	0	0	1	5696	1190	42	3		3	FBL	19	40328442	Silent	SNP	G	TCGA-06-0166-01A-01D-1491-08	29094559	40328442	18800541	50	1922											
ZNF180	7733	broad.mit.edu	37	chr19	44981674	44981674	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	agaattatttctcatgttttGagtaagggaggaactatgag	11	3	1	3			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr19:44981674G>A	uc002ozf.3	-	5	1306	c.1024C>T	c.(1024-1026)CAA>TAA	p.Q342*	ZNF180_uc002ozh.3_5'UTR|ZNF180_uc002ozi.3_Nonsense_Mutation_p.Q315*|ZNF180_uc002ozg.3_Nonsense_Mutation_p.Q341*|ZNF180_uc010ejm.2_Nonsense_Mutation_p.Q317*	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				CTCATGTTTTGAGTAAGGGAG	0.378													A	44981674	A	A	44981674	4	1	30	1	0	0	0	0	0	1	0	0	17745	1299	45	3	1058	3	ZNF180	19	44981674	Nonsense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	4653232	44981674	14147309	51	1923											
FPR3	2359	broad.mit.edu	37	chr19	52327921	52327921	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctctacgtctttatgggtcGtaacttccaagaaagactga	8	9	2	3			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr19:52327921G>A	uc002pxt.1	+	2	1104	c.920G>A	c.(919-921)CGT>CAT	p.R307H		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	307	Cytoplasmic (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						TTTATGGGTCGTAACTTCCAA	0.473													A	52327921	A	A	52327921	3	1	30	1	0	0	0	0	1	0	0	0	6040	1145	40	1	922	1	FPR3	19	52327921	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	7346247	52327921	6801062	52	1924											
MMP24	10893	broad.mit.edu	37	chr20	33851598	33851598	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acactcctctccacagggaaCgacctcttcctggtggctgt	9	15	2	0			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chr20:33851598C>T	uc002xbu.2	+	5	825	c.822C>T	c.(820-822)AAC>AAT	p.N274N	EDEM2_uc010zuv.1_Intron	NM_006690	NP_006681	Q9Y5R2	MMP24_HUMAN	matrix metalloproteinase 24 preproprotein	274	Extracellular (Potential).				proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCACAGGGAACGACCTCTTCC	0.522													T	33851598	T	T	33851598	2	4	30	1	0	0	0	0	0	0	0	1	9661	535	19	1		1	MMP24	20	33851598	Silent	SNP	C	TCGA-06-0166-01A-01D-1491-08		33851598	29173922	53	1925											
BCOR	54880	broad.mit.edu	37	chrX	39932171	39932171	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttagcatctggttcttctcGgagaaggtctacgtagacaa	10	8	4	2			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chrX:39932171G>A	uc004den.3	-	4	2720	c.2428C>T	c.(2428-2430)CGA>TGA	p.R810*	BCOR_uc004dep.3_Nonsense_Mutation_p.R810*|BCOR_uc004deo.3_Nonsense_Mutation_p.R810*|BCOR_uc004dem.3_Nonsense_Mutation_p.R810*|BCOR_uc004deq.3_Nonsense_Mutation_p.R810*	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	810					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						GGTTCTTCTCGGAGAAGGTCT	0.522													A	39932171	A	A	39932171	4	1	30	1	0	0	0	0	0	1	0	0	1386	1124	39	2	2887	2	BCOR	23	39932171	Nonsense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08		39932171	115338389	54	1926											
OTUD5	55593	broad.mit.edu	37	chrX	48814319	48814319	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcactgttgtagcctgcgcCgacctcctcacgctcgggac	10	17	2	0			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chrX:48814319C>T	uc004dlu.2	-	1	575	c.514G>A	c.(514-516)GGC>AGC	p.G172S	OTUD5_uc004dlt.3_Missense_Mutation_p.G172S|OTUD5_uc004dlv.2_Missense_Mutation_p.G172S|OTUD5_uc011mmp.1_Intron	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	172	Gly-rich.				negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						TAGCCTGCGCCGACCTCCTCA	0.687													T	48814319	T	T	48814319	3	4	30	1	0	0	0	0	1	0	0	0	11315	652	23	2	1237	2	OTUD5	23	48814319	Missense_Mutation	SNP	C	TCGA-06-0166-01A-01D-1491-08	8882148	48814319	106456241	55	1927											
MED12	9968	broad.mit.edu	37	chrX	70349202	70349202	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatccgctcctcctgcgaccGccacctgctggctgcctccc	8	21	0	0			TCGA-06-0166-01A-01D-1491-08	TCGA-06-0166-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	70157018-a3c5-4ef8-9314-f8715a3438a4	57898bbf-fde2-4dc4-9b2b-a9f8cd402cb0	g.chrX:70349202G>A	uc004dyy.2	+	26	3813	c.3614G>A	c.(3613-3615)CGC>CAC	p.R1205H	MED12_uc011mpq.1_Missense_Mutation_p.R1205H|MED12_uc004dyz.2_Missense_Mutation_p.R1205H|MED12_uc004dza.2_Missense_Mutation_p.R1052H|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1205					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TCCTGCGACCGCCACCTGCTG	0.582											OREG0019857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	70349202	A	A	70349202	3	1	30	1	0	0	0	0	1	0	0	0	9428	1087	38	1	3716	1	MED12	23	70349202	Missense_Mutation	SNP	G	TCGA-06-0166-01A-01D-1491-08	21534883	70349202	84921358	56	1928											
NPNT	255743	broad.mit.edu	37	chr4	106888371	106888371	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatatctgacagtgtcggcaGccaaagccccagggggaaaa	12	10	1	1	rs146652028		TCGA-06-0167-01A-01D-1491-08	TCGA-06-0167-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	d530c696-235d-4a41-944d-e7f7ae21aa17	74292da7-2a53-455d-8d33-438db411fa67	g.chr4:106888371G>A	uc003hya.2	+	11	1577	c.1372G>A	c.(1372-1374)GCC>ACC	p.A458T	NPNT_uc011cfc.1_Missense_Mutation_p.A475T|NPNT_uc011cfd.1_Missense_Mutation_p.A488T|NPNT_uc011cfe.1_Missense_Mutation_p.A459T|NPNT_uc010ilt.1_Missense_Mutation_p.A429T|NPNT_uc011cff.1_Missense_Mutation_p.A429T|NPNT_uc010ilu.1_Intron	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	458	MAM.				cell differentiation	membrane	calcium ion binding	p.A458T(1)		skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		AGTGTCGGCAGCCAAAGCCCC	0.552													A	106888371	A	A	106888371	3	1	31	1	0	0	0	0	1	0	0	0	10590	971	34	3	1563	3	NPNT	4	106888371	Missense_Mutation	SNP	G	TCGA-06-0167-01A-01D-1491-08		106888371	84265905	1	1929											
SEC24B	10427	broad.mit.edu	37	chr4	110437770	110437770	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatatttgacaattttgtgCcagtcactcctagaaaatct	7	8	2	2			TCGA-06-0167-01A-01D-1491-08	TCGA-06-0167-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	d530c696-235d-4a41-944d-e7f7ae21aa17	74292da7-2a53-455d-8d33-438db411fa67	g.chr4:110437770C>T	uc003hzk.2	+	11	2155	c.2100C>T	c.(2098-2100)TGC>TGT	p.C700C	SEC24B_uc003hzl.2_Silent_p.C665C|SEC24B_uc011cfp.1_Silent_p.C730C|SEC24B_uc011cfq.1_Silent_p.C699C|SEC24B_uc011cfr.1_Silent_p.C664C	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	700					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CAATTTTGTGCCAGTCACTCC	0.318													T	110437770	T	T	110437770	2	4	31	1	0	0	0	0	0	0	0	1	13995	747	26	3		3	SEC24B	4	110437770	Silent	SNP	C	TCGA-06-0167-01A-01D-1491-08	3549399	110437770	80716506	2	1930											
C6orf203	51250	broad.mit.edu	37	chr6	107372330	107372330	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggaacagagacagttatgCggattctcttgaaaaaagtg	11	6	1	2			TCGA-06-0167-01A-01D-1491-08	TCGA-06-0167-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	d530c696-235d-4a41-944d-e7f7ae21aa17	74292da7-2a53-455d-8d33-438db411fa67	g.chr6:107372330C>T	uc003prq.2	+	4	694	c.613C>T	c.(613-615)CGG>TGG	p.R205W	C6orf203_uc011eaj.1_Missense_Mutation_p.R210W|C6orf203_uc010kde.2_Missense_Mutation_p.R205W	NM_016487	NP_057571	Q9P0P8	CF203_HUMAN	hypothetical protein LOC51250 isoform a	205											0	Breast(9;0.00124)|all_epithelial(6;0.0729)	all_cancers(87;0.00461)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|Colorectal(196;0.171)|all_epithelial(87;0.23)	BRCA - Breast invasive adenocarcinoma(8;0.000395)|all cancers(7;0.00065)|Epithelial(6;0.000834)|OV - Ovarian serous cystadenocarcinoma(5;0.244)	BRCA - Breast invasive adenocarcinoma(108;0.117)		GACAGTTATGCGGATTCTCTT	0.383													T	107372330	T	T	107372330	3	4	31	1	0	0	0	0	1	0	0	0	2352	759	27	1	642	1	C6orf203	6	107372330	Missense_Mutation	SNP	C	TCGA-06-0167-01A-01D-1491-08		107372330	63742737	3	1931											
RTF1	23168	broad.mit.edu	37	chr15	41763442	41763442	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatcgggttcgattatcacgGcataagctagaacgctggtg	12	8	1	1			TCGA-06-0167-01A-01D-1491-08	TCGA-06-0167-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	d530c696-235d-4a41-944d-e7f7ae21aa17	74292da7-2a53-455d-8d33-438db411fa67	g.chr15:41763442G>A	uc001zny.2	+	8	1110	c.1098G>A	c.(1096-1098)CGG>CGA	p.R366R		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	366	Plus3.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		GATTATCACGGCATAAGCTAG	0.458													A	41763442	A	A	41763442	2	1	31	1	0	0	0	0	0	0	0	1	13721	1190	42	3		3	RTF1	15	41763442	Silent	SNP	G	TCGA-06-0167-01A-01D-1491-08		41763442	60767950	4	1932											
MRPL10	124995	broad.mit.edu	37	chr17	45905957	45905957	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcacagccatcagcttctgCcgctgaaagtgcatcacacg	9	14	4	1			TCGA-06-0167-01A-01D-1491-08	TCGA-06-0167-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	d530c696-235d-4a41-944d-e7f7ae21aa17	74292da7-2a53-455d-8d33-438db411fa67	g.chr17:45905957C>T	uc002ilz.2	-	2	158	c.132G>A	c.(130-132)CGG>CGA	p.R44R	MRPL10_uc010wky.1_Silent_p.R5R|MRPL10_uc002ily.2_Silent_p.R54R	NM_145255	NP_660298	Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10 precursor	44					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			ovary(1)	1						TCAGCTTCTGCCGCTGAAAGT	0.597													T	45905957	T	T	45905957	2	4	31	1	0	0	0	0	0	0	0	1	9775	726	26	3		3	MRPL10	17	45905957	Silent	SNP	C	TCGA-06-0167-01A-01D-1491-08		45905957	35289253	5	1933											
MSL3	10943	broad.mit.edu	37	chrX	11790350	11790350	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccctcttacatttatgggGcacaacatttgctgcgattg	8	11	1	0	rs140880282		TCGA-06-0167-01A-01D-1491-08	TCGA-06-0167-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	d530c696-235d-4a41-944d-e7f7ae21aa17	74292da7-2a53-455d-8d33-438db411fa67	g.chrX:11790350G>A	uc004cuw.2	+	11	1462	c.1357G>A	c.(1357-1359)GCA>ACA	p.A453T	MSL3_uc004cux.2_Missense_Mutation_p.A394T|MSL3_uc011mig.1_Missense_Mutation_p.A304T|MSL3_uc011mih.1_Missense_Mutation_p.A441T|MSL3_uc004cuy.2_Missense_Mutation_p.A287T	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	453					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CATTTATGGGGCACAACATTT	0.463													A	11790350	A	A	11790350	3	1	31	1	0	0	0	0	1	0	0	0	9879	1203	42	3	1479	3	MSL3	23	11790350	Missense_Mutation	SNP	G	TCGA-06-0167-01A-01D-1491-08		11790350	143480210	6	1934											
RBBP4	5928	broad.mit.edu	37	chr1	33134833	33134833	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtttttttttcactgaagtTgggatactcgttcaaacaat	7	6	2	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr1:33134833T>G	uc001bvr.2	+	7	922	c.763T>G	c.(763-765)TGG>GGG	p.W255G	RBBP4_uc001bvs.2_Missense_Mutation_p.W254G|RBBP4_uc010ohj.1_Missense_Mutation_p.W3G|RBBP4_uc010ohk.1_Missense_Mutation_p.W220G	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	255	WD 3.				cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				TCACTGAAGTTGGGATACTCG	0.353													G	33134833	G	G	33134833	3	3	32	1	0	0	0	0	1	0	0	0	13101	1826	63	5	789	5	RBBP4	1	33134833	Missense_Mutation	SNP	T	TCGA-06-0168-01A-01D-1491-08		33134833	216115788	1	1935											
CYP4A11	1579	broad.mit.edu	37	chr1	47399686	47399686	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgccaatgcctggcaccGgtgggtagagcctcagtgcc	13	14	2	1	rs66477740		TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr1:47399686G>A	uc001cqp.3	-	9	1205	c.1154C>T	c.(1153-1155)CCG>CTG	p.P385L	CYP4A11_uc001cqq.2_Missense_Mutation_p.P385L|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	385					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GCCTGGCACCGGTGGGTAGAG	0.567													A	47399686	A	A	47399686	3	1	32	1	0	0	0	0	1	0	0	0	4183	1116	39	2	421	2	CYP4A11	1	47399686	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	14264853	47399686	201850935	2	1936											
LRP8	7804	broad.mit.edu	37	chr1	53732253	53732253	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatgaggcgtgaatagttcCgcttcaccaggtcgatcctc	12	11	1	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr1:53732253C>T	uc001cvi.1	-	9	1461	c.1319G>A	c.(1318-1320)CGG>CAG	p.R440Q	LRP8_uc001cvh.1_5'UTR|LRP8_uc001cvk.1_Missense_Mutation_p.R270Q|LRP8_uc001cvj.1_Missense_Mutation_p.R440Q|LRP8_uc001cvl.1_Missense_Mutation_p.R311Q|LRP8_uc001cvm.1_Missense_Mutation_p.R25Q	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	440	Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						TGAATAGTTCCGCTTCACCAG	0.537													T	53732253	T	T	53732253	3	4	32	1	0	0	0	0	1	0	0	0	8963	652	23	2	1616	2	LRP8	1	53732253	Missense_Mutation	SNP	C	TCGA-06-0168-01A-01D-1491-08	6332567	53732253	195518368	3	1937											
FLG	2312	broad.mit.edu	37	chr1	152285273	152285273	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acttgatcttgcctgttcatGggatgacgcagcctgtccac	10	12	2	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr1:152285273G>T	uc001ezu.1	-	3	2125	c.2089C>A	c.(2089-2091)CAT>AAT	p.H697N	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	697	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGTTCATGGGATGACGCA	0.557									Ichthyosis				T	152285273	T	T	152285273	3	4	32	1	0	0	0	0	1	0	0	0	5922	1348	47	5	10100	5	FLG	1	152285273	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	98553020	152285273	96965348	4	1938											
LCE1F	353137	broad.mit.edu	37	chr1	152748961	152748961	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagtgtccccctaagtgcccTcctgtctcttcctgctgcag	8	16	1	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr1:152748961T>C	uc010pdv.1	+	1	114	c.114T>C	c.(112-114)CCT>CCC	p.P38P		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	38	Pro-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ctaagtgccctccTGTCTCTT	0.408													C	152748961	C	C	152748961	2	2	32	1	0	0	0	0	0	0	0	1	8664	1538	54	4		4	LCE1F	1	152748961	Silent	SNP	T	TCGA-06-0168-01A-01D-1491-08	463688	152748961	96501660	5	1939											
C1orf66	51093	broad.mit.edu	37	chr1	156702252	156702252	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagaagcagcatgagatccGgaggctgggagaggtgagga	18	6	0	4			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr1:156702252G>A	uc001fpu.2	+	3	1050	c.416G>A	c.(415-417)CGG>CAG	p.R139Q	C1orf66_uc001fpv.2_Missense_Mutation_p.R139Q	NM_015997	NP_057081	Q96FB5	RRNAD_HUMAN	hypothetical protein LOC51093 isoform 1	139						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CATGAGATCCGGAGGCTGGGA	0.562													A	156702252	A	A	156702252	3	1	32	1	0	0	0	0	1	0	0	0	2056	1116	39	2	426	2	C1orf66	1	156702252	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	3953291	156702252	92548369	6	1940											
USH2A	7399	broad.mit.edu	37	chr1	215814045	215814045	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacaccacagacaaattgctGtccaccgaaaatggggctcg	9	13	0	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr1:215814045G>A	uc001hku.1	-	68	15210	c.14823C>T	c.(14821-14823)GAC>GAT	p.D4941D		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4941	Fibronectin type-III 35.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAAATTGCTGTCCACCGAAA	0.507										HNSCC(13;0.011)			A	215814045	A	A	215814045	2	1	32	1	0	0	0	0	0	0	0	1	17033	1368	48	3		3	USH2A	1	215814045	Silent	SNP	G	TCGA-06-0168-01A-01D-1491-08	59111793	215814045	33436576	7	1941											
LYST	1130	broad.mit.edu	37	chr1	235969724	235969724	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttacttacgcataaaaaagcCacacagaggaataggtttat	7	7	0	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr1:235969724C>T	uc001hxj.2	-	6	2887	c.2712G>A	c.(2710-2712)GTG>GTA	p.V904V	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Silent_p.V904V	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	904					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATAAAAAAGCCACACAGAGGA	0.428									Chediak-Higashi_syndrome				T	235969724	T	T	235969724	2	4	32	1	0	0	0	0	0	0	0	1	9128	581	21	3		3	LYST	1	235969724	Silent	SNP	C	TCGA-06-0168-01A-01D-1491-08	20155679	235969724	13280897	8	1942											
MTA3	57504	broad.mit.edu	37	chr2	42883411	42883411	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caaatagcccacttacggatCgacagattgaccagttttta	7	10	0	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr2:42883411C>T	uc002rso.1	+	8	1073	c.403C>T	c.(403-405)CGA>TGA	p.R135*	MTA3_uc002rsp.1_Nonsense_Mutation_p.R135*|MTA3_uc002rsq.2_Nonsense_Mutation_p.R191*|MTA3_uc002rsr.2_Nonsense_Mutation_p.R191*	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	191	ELM2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ACTTACGGATCGACAGATTGA	0.328													T	42883411	T	T	42883411	4	4	32	1	0	0	0	0	0	1	0	0	9910	876	31	2	597	2	MTA3	2	42883411	Nonsense_Mutation	SNP	C	TCGA-06-0168-01A-01D-1491-08		42883411	200315962	9	1943											
REV1	51455	broad.mit.edu	37	chr2	100024503	100024507	+	Frame_Shift_Del	DEL	TGATA	-	-													atacttacccctctcatatcTgatatatttagtttcattgt							TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr2:100024503_100024507delTGATA	uc002tad.2	-	15	2644_2648	c.2432_2436delTATCA	c.(2431-2436)ATATCAfs	p.I811fs	REV1_uc002tac.2_Frame_Shift_Del_p.I810fs	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	811_812					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						CTCTCATATCTGATATATTTAGTTT	0.346								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					-	100024507	-	-	100024503	7	5	32	1	0	1	0	1	0	0	0	0	13239	1567	55	0	1355	0	REV1	2	100024503	Frame_Shift_Del	DEL	TGATA	TCGA-06-0168-01A-01D-1491-08	57141092	100024503	143174870	10	1944											
SEPT10	151011	broad.mit.edu	37	chr2	110303622	110303625	+	Splice_Site	DEL	CTTA	-	-													cagggagggtggctgggcctCttacttcttacggtccttgt							TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr2:110303622_110303625delCTTA	uc002tew.2	-	10	1728	c.1349_splice	c.e10+1	p.N450_splice	SEPT10_uc010ywu.1_3'UTR|SEPT10_uc002tex.2_Splice_Site_p.N427_splice|SEPT10_uc002tey.2_Splice_Site_p.K450_splice|SEPT10_uc010ywv.1_Splice_Site_p.N316_splice|SEPT10_uc002tev.1_3'UTR|SEPT10_uc010fjo.2_Splice_Site	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1						cell cycle|cell division	septin complex	GTP binding				0						GGCTGGGCCTCTTACTTCTTACGG	0.495											OREG0014878	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	110303625	-	-	110303622	8	5	32	1	0	1	0	1	0	0	1	0	14060	928	32	0		0	SEPT10	2	110303622	Splice_Site	DEL	CTTA	TCGA-06-0168-01A-01D-1491-08	10279119	110303622	132895751	11	1945											
POTEF	728378	broad.mit.edu	37	chr2	130877828	130877828	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agtgtcttcatagcagagtcGtcgtggtctccagaagcgcc	12	11	3	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr2:130877828G>T	uc010fmh.2	-	3	661	c.261C>A	c.(259-261)GAC>GAA	p.D87E		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	87						cell cortex	ATP binding			skin(3)|ovary(2)	5						TAGCAGAGTCGTCGTGGTCTC	0.612													T	130877828	T	T	130877828	3	4	32	1	0	0	0	0	1	0	0	0	12265	1136	40	5	3026	5	POTEF	2	130877828	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	20574206	130877828	112321545	12	1946											
ITGAV	3685	broad.mit.edu	37	chr2	187506166	187506166	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catggatcgtggctctgatgGcaaactccaagaggtggggc	15	9	1	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr2:187506166G>A	uc002upq.2	+	12	1286	c.1010G>A	c.(1009-1011)GGC>GAC	p.G337D	ITGAV_uc010frs.2_Missense_Mutation_p.G301D|ITGAV_uc010zfv.1_Missense_Mutation_p.G291D	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	337	FG-GAP 5.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GGCTCTGATGGCAAACTCCAA	0.458													A	187506166	A	A	187506166	3	1	32	1	0	0	0	0	1	0	0	0	7888	1203	42	3	1107	3	ITGAV	2	187506166	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	56628338	187506166	55693207	13	1947											
SGOL2	151246	broad.mit.edu	37	chr2	201437521	201437521	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgtatgtcaaaagtcagaaAtaattcctgaaaccaaccaa	5	8	2	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr2:201437521A>G	uc002uvw.2	+	7	2565	c.2452A>G	c.(2452-2454)ATA>GTA	p.I818V	SGOL2_uc010zhd.1_Missense_Mutation_p.I818V|SGOL2_uc010zhe.1_Missense_Mutation_p.I818V	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	818					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AAAGTCAGAAATAATTCCTGA	0.348													G	201437521	G	G	201437521	3	3	32	1	0	0	0	0	1	0	0	0	14217	101	4	4	2474	4	SGOL2	2	201437521	Missense_Mutation	SNP	A	TCGA-06-0168-01A-01D-1491-08	13931355	201437521	41761852	14	1948											
FGFR3	2261	broad.mit.edu	37	chr4	1807889	1807889	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaacctcgactactacaagAagacgaccaacgtgagcccg	8	14	0	3	rs78311289		TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr4:1807889A>G	uc003gdr.3	+	14	2204	c.1948A>G	c.(1948-1950)AAG>GAG	p.K650E	FGFR3_uc003gdu.2_Missense_Mutation_p.K652E|FGFR3_uc003gds.3_Missense_Mutation_p.K538E|FGFR3_uc003gdq.3_Missense_Mutation_p.K651E	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	650	Protein kinase.|Cytoplasmic (Potential).		K -> E (in KERSEB, TD2 and bladder cancer samples; bladder transitional cell carcinoma; somatic mutation).|K -> Q (in hypochondroplasia and bladder cancer; in hypochondroplasia the form is milder than that seen in individuals with the K-540 or M-650 mutations).|K -> M (in KERSEB, ACH and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.K650M(76)|p.K650E(71)|p.K650Q(5)|p.K650T(5)|p.K650N(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CTACTACAAGAAGACGACCAA	0.667		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				G	1807889	G	G	1807889	3	3	32	1	0	0	0	0	1	0	0	0	5867	247	9	4	2153	4	FGFR3	4	1807889	Missense_Mutation	SNP	A	TCGA-06-0168-01A-01D-1491-08		1807889	189346387	15	1949											
BANK1	55024	broad.mit.edu	37	chr4	102984233	102984233	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggttgtttccacattaaggAgaaattacgacaactacgag	9	7	0	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr4:102984233A>C	uc003hvy.3	+	13	2424	c.2150A>C	c.(2149-2151)GAG>GCG	p.E717A	BANK1_uc003hvx.3_Missense_Mutation_p.E702A|BANK1_uc010ill.2_Missense_Mutation_p.E584A|BANK1_uc003hvz.3_Missense_Mutation_p.E687A	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	717					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		CACATTAAGGAGAAATTACGA	0.323													C	102984233	C	C	102984233	3	2	32	1	0	0	0	0	1	0	0	0	1309	318	11	5	2200	5	BANK1	4	102984233	Missense_Mutation	SNP	A	TCGA-06-0168-01A-01D-1491-08	101176344	102984233	88170043	16	1950											
NDST4	64579	broad.mit.edu	37	chr4	115792048	115792048	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agttgaccaagttcacaaagGtatataaccctaggcggtca	9	9	2	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr4:115792048G>C	uc003ibu.2	-	7	2274	c.1595C>G	c.(1594-1596)ACC>AGC	p.T532S	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	532	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GTTCACAAAGGTATATAACCC	0.403													C	115792048	C	C	115792048	3	2	32	1	0	0	0	0	1	0	0	0	10258	1261	44	5	1055	5	NDST4	4	115792048	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	12807815	115792048	75362228	17	1951											
NDST3	9348	broad.mit.edu	37	chr4	118975673	118975673	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcattctccattgattcGtgtgaccaaatcttccaagc	5	13	3	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr4:118975673G>A	uc003ibx.2	+	2	1011	c.608G>A	c.(607-609)CGT>CAT	p.R203H	NDST3_uc011cgf.1_Missense_Mutation_p.R203H|NDST3_uc003ibw.2_Missense_Mutation_p.R203H	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	203	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CCATTGATTCGTGTGACCAAA	0.358													A	118975673	A	A	118975673	3	1	32	1	0	0	0	0	1	0	0	0	10257	1145	40	1	610	1	NDST3	4	118975673	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	3183625	118975673	72178603	18	1952											
ASB5	140458	broad.mit.edu	37	chr4	177190191	177190191	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaagcttaaaacagaacagCgaaagtattgtaaagtagac	8	5	0	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr4:177190191C>T	uc003iuq.1	-	1	85	c.69G>A	c.(67-69)TCG>TCA	p.S23S		NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	23					intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		AACAGAACAGCGAAAGTATTG	0.433													T	177190191	T	T	177190191	2	4	32	1	0	0	0	0	0	0	0	1	1026	755	27	1		1	ASB5	4	177190191	Silent	SNP	C	TCGA-06-0168-01A-01D-1491-08	58214518	177190191	13964085	19	1953											
PCDHA3	56145	broad.mit.edu	37	chr5	140182149	140182149	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgacaatgcgccggcattctCgcagtccgagtacacggtgt	12	13	1	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr5:140182149C>T	uc003lhf.2	+	1	1367	c.1367C>T	c.(1366-1368)TCG>TTG	p.S456L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.S456L	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	456	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGGCATTCTCGCAGTCCGAG	0.672													T	140182149	T	T	140182149	3	4	32	1	0	0	0	0	1	0	0	0	11525	893	31	2	1369	2	PCDHA3	5	140182149	Missense_Mutation	SNP	C	TCGA-06-0168-01A-01D-1491-08		140182149	40733111	20	1954											
PCDHB13	56123	broad.mit.edu	37	chr5	140595338	140595338	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcagcgaggcgctggtgcGcgtggtggtgctggacgcca	20	10	0	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr5:140595338G>A	uc003lja.1	+	1	1830	c.1643G>A	c.(1642-1644)CGC>CAC	p.R548H		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	548	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGCTGGTGCGCGTGGTGGTG	0.716													A	140595338	A	A	140595338	3	1	32	1	0	0	0	0	1	0	0	0	11538	1087	38	1	1645	1	PCDHB13	5	140595338	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	413189	140595338	40319922	21	1955											
PRPF4B	8899	broad.mit.edu	37	chr6	4042762	4042762	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaagaagatgaagaagcccTaatagaacagagaagaatcc	11	6	0	7			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr6:4042762T>C	uc003mvv.2	+	5	1701	c.1610T>C	c.(1609-1611)CTA>CCA	p.L537P	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	537						catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				GAAGAAGCCCTAATAGAACAG	0.313													C	4042762	C	C	4042762	3	2	32	1	0	0	0	0	1	0	0	0	12573	1522	53	4	1628	4	PRPF4B	6	4042762	Missense_Mutation	SNP	T	TCGA-06-0168-01A-01D-1491-08		4042762	167072305	22	1956											
OR2H1	26716	broad.mit.edu	37	chr6	29430141	29430141	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acaatgaaatccagttggctGtgtccagtgtcatcttcgtg	10	9	2	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr6:29430141G>C	uc003nmi.2	+	3	1038	c.595G>C	c.(595-597)GTG>CTG	p.V199L	OR2H1_uc003nmj.1_Missense_Mutation_p.V199L|OR2H1_uc010jri.1_Missense_Mutation_p.V121L	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCAGTTGGCTGTGTCCAGTGT	0.512													C	29430141	C	C	29430141	3	2	32	1	0	0	0	0	1	0	0	0	11001	1377	48	5	597	5	OR2H1	6	29430141	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	25387379	29430141	141684926	23	1957											
DST	667	broad.mit.edu	37	chr6	56566691	56566691	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaaaacatcatacctggcGtcttttcaaatagtcaagtg	6	9	5	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr6:56566691G>A	uc003pdf.2	-	7	878	c.850C>T	c.(850-852)CGC>TGC	p.R284C	DST_uc003pcz.3_Missense_Mutation_p.R106C|DST_uc011dxj.1_Missense_Mutation_p.R135C|DST_uc011dxk.1_Missense_Mutation_p.R146C|DST_uc011dxl.1_Missense_Mutation_p.R135C	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	106	CH 1.|Actin-binding.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CATACCTGGCGTCTTTTCAAA	0.343													A	56566691	A	A	56566691	3	1	32	1	0	0	0	0	1	0	0	0	4783	1160	40	1		1	DST	6	56566691	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	27136550	56566691	114548376	24	1958											
SASH1	23328	broad.mit.edu	37	chr6	148854037	148854037	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttaccgaggcccgttctgcGggcgtgccagggtgcacacc	14	15	1	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr6:148854037G>A	uc003qme.1	+	14	2144	c.1669G>A	c.(1669-1671)GGG>AGG	p.G557R	SASH1_uc011eeb.1_Missense_Mutation_p.G318R|SASH1_uc003qmf.1_5'UTR	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	557	SH3.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CCCGTTCTGCGGGCGTGCCAG	0.582													A	148854037	A	A	148854037	3	1	32	1	0	0	0	0	1	0	0	0	13848	1116	39	2	1723	2	SASH1	6	148854037	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	92287346	148854037	22261030	25	1959											
GRM3	2913	broad.mit.edu	37	chr7	86415679	86415679	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgattactttgccaggaccGtgccccccgacttctaccag	8	15	1	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr7:86415679G>A	uc003uid.2	+	3	1670	c.571G>A	c.(571-573)GTG>ATG	p.V191M	GRM3_uc010lef.2_Missense_Mutation_p.V189M|GRM3_uc010leg.2_Missense_Mutation_p.V63M|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	191	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGCCAGGACCGTGCCCCCCGA	0.567													A	86415679	A	A	86415679	3	1	32	1	0	0	0	0	1	0	0	0	6798	1145	40	1	577	1	GRM3	7	86415679	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08		86415679	72722984	26	1960											
MUC17	140453	broad.mit.edu	37	chr7	100678176	100678176	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acctcccagtgaaggaaccaCtccgttagcaagtatgcctg	9	13	0	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr7:100678176C>G	uc003uxp.1	+	3	3532	c.3479C>G	c.(3478-3480)ACT>AGT	p.T1160S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1160	Extracellular (Potential).|59 X approximate tandem repeats.|17.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGGAACCACTCCGTTAGCA	0.522													G	100678176	G	G	100678176	3	3	32	1	0	0	0	0	1	0	0	0	9974	565	20	5	3489	5	MUC17	7	100678176	Missense_Mutation	SNP	C	TCGA-06-0168-01A-01D-1491-08	14262497	100678176	58460487	27	1961											
PTPRZ1	5803	broad.mit.edu	37	chr7	121636615	121636615	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttttgacagatggctatcaaGacttggtaactatatgatca	8	6	2	4			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr7:121636615G>C	uc003vjy.2	+	9	1503	c.1108G>C	c.(1108-1110)GAC>CAC	p.D370H	PTPRZ1_uc003vjz.2_Missense_Mutation_p.D370H	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	370	Extracellular (Potential).|Fibronectin type-III.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TGGCTATCAAGACTTGGTAAC	0.338													C	121636615	C	C	121636615	3	2	32	1	0	0	0	0	1	0	0	0	12814	942	33	5	1142	5	PTPRZ1	7	121636615	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	20958439	121636615	37502048	28	1962											
EPHB6	2051	broad.mit.edu	37	chr7	142562429	142562430	+	Missense_Mutation	DNP	AA	CC	CC													tgcactgcaacggggagggcAagtggatggtagctgtcggg							TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr7:142562429_142562430AA>CC	uc011kst.1	+	7	1658_1659	c.871_872AA>CC	c.(871-873)AAG>CCG	p.K291P	EPHB6_uc011ksu.1_Missense_Mutation_p.K291P|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_5'UTR|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	291	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CGGGGAGGGCAAGTGGATGGTA	0.653													CC	142562430	CC	CC	142562429	3	2	32	1	0	0	0	0	1	0	0	0	5178	131	5	5	881	5	EPHB6	7	142562429	Missense_Mutation	DNP	AA	TCGA-06-0168-01A-01D-1491-08	20925814	142562429	16576234	29	1963											
SLCO5A1	81796	broad.mit.edu	37	chr8	70594493	70594493	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgtaattccatctgatccacAgactggctcatactcgtgta	7	11	2	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr8:70594493A>T	uc003xyl.2	-	7	2415	c.1708T>A	c.(1708-1710)TGT>AGT	p.C570S	SLCO5A1_uc010lzb.2_Missense_Mutation_p.C515S|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.C570S	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	570	Extracellular (Potential).|Kazal-like.					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TCTGATCCACAGACTGGCTCA	0.428													T	70594493	T	T	70594493	3	4	32	1	0	0	0	0	1	0	0	0	14731	188	7	5	854	5	SLCO5A1	8	70594493	Missense_Mutation	SNP	A	TCGA-06-0168-01A-01D-1491-08		70594493	75769529	30	1964											
C9orf66	157983	broad.mit.edu	37	chr9	214614	214614	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcgggcagatggagcttccgGcctgcgcgcagtggtcgcct	16	13	0	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr9:214614G>T	uc003zge.3	-	1	1280	c.783C>A	c.(781-783)GGC>GGA	p.G261G	DOCK8_uc011lls.1_5'Flank|DOCK8_uc003zgf.2_5'Flank	NM_152569	NP_689782	Q5T8R8	CI066_HUMAN	hypothetical protein LOC157983	261	Arg-rich.									central_nervous_system(1)	1	all_lung(41;0.218)	all_cancers(5;2.09e-12)|all_epithelial(5;6.16e-09)|all_lung(10;1.15e-08)|Lung NSC(10;1.91e-08)|Acute lymphoblastic leukemia(5;0.00457)|all_hematologic(5;0.0332)|Breast(48;0.0646)|Prostate(43;0.137)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GGAGCTTCCGGCCTGCGCGCA	0.711													T	214614	T	T	214614	2	4	32	1	0	0	0	0	0	0	0	1	2490	1190	42	5		5	C9orf66	9	214614	Silent	SNP	G	TCGA-06-0168-01A-01D-1491-08		214614	140998817	31	1965											
SVEP1	79987	broad.mit.edu	37	chr9	113169426	113169426	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcatcctcatcccagtttttGtcatcctggcatgttctcct	5	14	4	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr9:113169426G>C	uc010mtz.2	-	38	8791	c.8454C>G	c.(8452-8454)GAC>GAG	p.D2818E	SVEP1_uc010mty.2_Missense_Mutation_p.D744E	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2818	Sushi 23.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CCCAGTTTTTGTCATCCTGGC	0.512													C	113169426	C	C	113169426	3	2	32	1	0	0	0	0	1	0	0	0	15417	1368	48	5	2305	5	SVEP1	9	113169426	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	112954812	113169426	28044005	32	1966											
RTKN2	219790	broad.mit.edu	37	chr10	63957964	63957964	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gattttaagctgaatggaagTttatcagaaggaggaagggg	15	2	1	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr10:63957964T>C	uc001jlw.2	-	12	1630	c.1533A>G	c.(1531-1533)AAA>AAG	p.K511K	RTKN2_uc009xpf.1_Intron|RTKN2_uc001jlv.2_Silent_p.K165K	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	511					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					TGAATGGAAGTTTATCAGAAG	0.398													C	63957964	C	C	63957964	2	2	32	1	0	0	0	0	0	0	0	1	13723	1722	60	4		4	RTKN2	10	63957964	Silent	SNP	T	TCGA-06-0168-01A-01D-1491-08		63957964	71576783	33	1967											
PTEN	5728	broad.mit.edu	37	chr10	89720827	89720831	+	Frame_Shift_Del	DEL	CAAAG	-	-													ttaacaaaaaatgatcttgaCaaagcaaataaagacaaagc							TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr10:89720827_89720831delCAAAG	uc001kfb.2	+	9	2009_2013	c.978_982delCAAAG	c.(976-984)GACAAAGCAfs	p.D326fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	326_328	C2 tensin-type.			KANKDKANR->AAGADAANA: Reduces growth suppression activity and promotes anchorage-independent growth. Reduces binding to phospholipid membranes in vitro; phosphatase activity towards PtdIns(3,4,5)P3 is not affected.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.T319_K332del(1)|p.G165_*404del(1)|p.D326G(1)|p.G165_K342del(1)|p.D326fs*4(1)|p.W274_F341del(1)|p.A328fs*1(1)|p.D326_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ATGATCTTGACAAAGCAAATAAAGA	0.337		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89720831	-	-	89720827	7	5	32	1	0	1	0	1	0	0	0	0	12738	477	17	0	1008	0	PTEN	10	89720827	Frame_Shift_Del	DEL	CAAAG	TCGA-06-0168-01A-01D-1491-08	25762863	89720827	45813920	34	1968											
OR10A3	26496	broad.mit.edu	37	chr11	7960190	7960190	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcctcttcatctcactgtttCgtaagctatagatgagcgga	8	10	3	2	rs146552050		TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr11:7960190C>T	uc010rbi.1	-	1	878	c.878G>A	c.(877-879)CGA>CAA	p.R293Q		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTCACTGTTTCGTAAGCTATA	0.418													T	7960190	T	T	7960190	3	4	32	1	0	0	0	0	1	0	0	0	10891	884	31	2	69	2	OR10A3	11	7960190	Missense_Mutation	SNP	C	TCGA-06-0168-01A-01D-1491-08		7960190	127046326	35	1969											
SPRYD5	84767	broad.mit.edu	37	chr11	55653196	55653197	+	Missense_Mutation	DNP	GA	TC	TC													aaatatgtgggatgcacagaGagacaaagaagatgttctgt							TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr11:55653196_55653197GA>TC	uc010rip.1	+	2	384_385	c.292_293GA>TC	c.(292-294)GAG>TCG	p.E98S	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	98	B box-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GATGCACAGAGAGACAAAGAAG	0.485													TC	55653197	TC	TC	55653196	3	4	32	1	0	0	0	0	1	0	0	0	15110	943	33	5	294	5	SPRYD5	11	55653196	Missense_Mutation	DNP	GA	TCGA-06-0168-01A-01D-1491-08	47693006	55653196	79353320	36	1970			1	8		3	3	5719	N	T_GA_A	5.502687e-05
SPRYD5	84767	broad.mit.edu	37	chr11	55658647	55658647	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaagagccaatagtcatAtcttcctgtgtggagatttg	10	7	2	3			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr11:55658647A>T	uc010rip.1	+	7	990	c.898A>T	c.(898-900)ATC>TTC	p.I300F	SPRYD5_uc010riq.1_Missense_Mutation_p.I157F	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	300	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CAATAGTCATATCTTCCTGTG	0.348													T	55658647	T	T	55658647	3	4	32	1	0	0	0	0	1	0	0	0	15110	449	16	5	920	5	SPRYD5	11	55658647	Missense_Mutation	SNP	A	TCGA-06-0168-01A-01D-1491-08	5451	55658647	79347869	37	1971			1	8		3	3	5719	N	T_GA_A	5.502687e-05
SPRYD5	84767	broad.mit.edu	37	chr11	55658914	55658914	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtgttaaggaggacactcacTgcagtctctttaccacctcc	8	13	2	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr11:55658914T>A	uc010rip.1	+	7	1257	c.1165T>A	c.(1165-1167)TGC>AGC	p.C389S	SPRYD5_uc010riq.1_Missense_Mutation_p.C246S	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	389	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GGACACTCACTGCAGTCTCTT	0.448													A	55658914	A	A	55658914	3	1	32	1	0	0	0	0	1	0	0	0	15110	1580	55	5	1187	5	SPRYD5	11	55658914	Missense_Mutation	SNP	T	TCGA-06-0168-01A-01D-1491-08	267	55658914	79347602	38	1972			1	8		3	3	5719	N	T_GA_A	5.502687e-05
OR8J3	81168	broad.mit.edu	37	chr11	55904831	55904831	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttacaaatggccacatagcGgtcataggccatcacagcca	9	12	2	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr11:55904831G>A	uc010riz.1	-	1	364	c.364C>T	c.(364-366)CGC>TGC	p.R122C		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					GCCACATAGCGGTCATAGGCC	0.502													A	55904831	A	A	55904831	3	1	32	1	0	0	0	0	1	0	0	0	11242	1116	39	2	585	2	OR8J3	11	55904831	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	245917	55904831	79101685	39	1973											
OR5A1	219982	broad.mit.edu	37	chr11	59210873	59210873	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcattgacatctgctactctTctgctgtggctcccaatatg	7	12	4	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr11:59210873T>C	uc001nnx.1	+	1	232	c.232T>C	c.(232-234)TCT>CCT	p.S78P		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	78	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						CTGCTACTCTTCTGCTGTGGC	0.468													C	59210873	C	C	59210873	3	2	32	1	0	0	0	0	1	0	0	0	11139	1783	62	4	234	4	OR5A1	11	59210873	Missense_Mutation	SNP	T	TCGA-06-0168-01A-01D-1491-08	3306042	59210873	75795643	40	1974											
CDC42BPG	55561	broad.mit.edu	37	chr11	64607007	64607007	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagccaggcgaatgtgcccGttcacatccagcaggacgtt	11	13	2	0	rs141134240	byFrequency	TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr11:64607007G>A	uc001obs.3	-	6	618	c.618C>T	c.(616-618)AAC>AAT	p.N206N		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	206	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						GAATGTGCCCGTTCACATCCA	0.607													A	64607007	A	A	64607007	2	1	32	1	0	0	0	0	0	0	0	1	3074	1136	40	1		1	CDC42BPG	11	64607007	Silent	SNP	G	TCGA-06-0168-01A-01D-1491-08	5396134	64607007	70399509	41	1975											
UVRAG	7405	broad.mit.edu	37	chr11	75718654	75718654	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgagctttcctacatttacCctattgatttggtaagtttc	6	9	0	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr11:75718654C>G	uc001oxc.2	+	10	1229	c.988C>G	c.(988-990)CCT>GCT	p.P330A	UVRAG_uc010rrw.1_Missense_Mutation_p.P229A|UVRAG_uc001oxd.2_5'UTR|UVRAG_uc010rrx.1_5'UTR|UVRAG_uc009yuh.1_RNA	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	330					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						CTACATTTACCCTATTGATTT	0.318													G	75718654	G	G	75718654	3	3	32	1	0	0	0	0	1	0	0	0	17105	623	22	5	1026	5	UVRAG	11	75718654	Missense_Mutation	SNP	C	TCGA-06-0168-01A-01D-1491-08	11111647	75718654	59287862	42	1976											
SMAGP	57228	broad.mit.edu	37	chr12	51663060	51663060	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ggagtagtcaggaggctggtCattgtcactagtggttgagt	16	5	3	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr12:51663060C>G	uc001ryc.1	-	1	674	c.3G>C	c.(1-3)ATG>ATC	p.M1I	SMAGP_uc001ryd.1_Missense_Mutation_p.M1I|SMAGP_uc001rye.1_Missense_Mutation_p.M1I|SMAGP_uc001ryf.1_RNA	NM_001033873	NP_001029045	Q0VAQ4	SMAGP_HUMAN	small trans-membrane and glycosylated protein	1	Extracellular (Potential).					cytoplasmic vesicle membrane|integral to membrane|plasma membrane					0						GGAGGCTGGTCATTGTCACTA	0.512													G	51663060	G	G	51663060	3	3	32	1	0	0	0	0	1	0	0	0	14765	826	29	5	302	5	SMAGP	12	51663060	Missense_Mutation	SNP	C	TCGA-06-0168-01A-01D-1491-08		51663060	82188835	43	1977											
RNF17	56163	broad.mit.edu	37	chr13	25367336	25367336	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaccacctcctttgcaaccTgagacaaatgatgtacattt	5	13	0	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr13:25367336T>C	uc001upr.2	+	10	1133	c.1092T>C	c.(1090-1092)CCT>CCC	p.P364P	RNF17_uc010tdd.1_Silent_p.P223P|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Silent_p.P364P|RNF17_uc001ups.2_Silent_p.P303P|RNF17_uc001upq.1_Silent_p.P364P	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	364					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTTTGCAACCTGAGACAAATG	0.428													C	25367336	C	C	25367336	2	2	32	1	0	0	0	0	0	0	0	1	13461	1567	55	4		4	RNF17	13	25367336	Silent	SNP	T	TCGA-06-0168-01A-01D-1491-08		25367336	89802542	44	1978											
TRPC4	7223	broad.mit.edu	37	chr13	38237609	38237609	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctttgcaggttaaccctttCgtttcttcataatagaagta	6	9	2	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr13:38237609C>T	uc001uws.2	-	6	1867	c.1632G>A	c.(1630-1632)ACG>ACA	p.T544T	TRPC4_uc010abv.2_Silent_p.T124T|TRPC4_uc001uwt.2_Silent_p.T544T|TRPC4_uc010tey.1_Silent_p.T544T|TRPC4_uc010abw.2_Silent_p.T371T|TRPC4_uc010abx.2_Silent_p.T544T|TRPC4_uc010aby.2_Silent_p.T544T	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	544	Extracellular (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTAACCCTTTCGTTTCTTCAT	0.348													T	38237609	T	T	38237609	2	4	32	1	0	0	0	0	0	0	0	1	16577	871	31	2		2	TRPC4	13	38237609	Silent	SNP	C	TCGA-06-0168-01A-01D-1491-08	12870273	38237609	76932269	45	1979											
COL4A1	1282	broad.mit.edu	37	chr13	110855947	110855947	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caggaggacctgcttcacccTtttctccctacaaaagaaaa	6	13	2	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr13:110855947T>C	uc001vqw.3	-	18	1087	c.965A>G	c.(964-966)AAG>AGG	p.K322R	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	322	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TGCTTCACCCTTTTCTCCCTA	0.453													C	110855947	C	C	110855947	3	2	32	1	0	0	0	0	1	0	0	0	3689	1609	56	4	4184	4	COL4A1	13	110855947	Missense_Mutation	SNP	T	TCGA-06-0168-01A-01D-1491-08	72618338	110855947	4313931	46	1980											
MAP3K9	4293	broad.mit.edu	37	chr14	71209191	71209191	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgatgatgttgagctcccGttccaggatgtcaatctccc	10	11	2	3			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr14:71209191G>A	uc001xmm.2	-	6	1444	c.1444C>T	c.(1444-1446)CGG>TGG	p.R482W	MAP3K9_uc010ttk.1_Missense_Mutation_p.R219W|MAP3K9_uc001xmk.2_Missense_Mutation_p.R176W|MAP3K9_uc001xml.2_Missense_Mutation_p.R482W	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	482	Leucine-zipper 2.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TTGAGCTCCCGTTCCAGGATG	0.617													A	71209191	A	A	71209191	3	1	32	1	0	0	0	0	1	0	0	0	9257	1144	40	1	1944	1	MAP3K9	14	71209191	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08		71209191	36140349	47	1981											
EPB42	2038	broad.mit.edu	37	chr15	43499445	43499445	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtcctcgcagcggtcactgcCcacacccttggtgctgatgt	11	15	1	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr15:43499445C>A	uc001zra.3	-	9	1570	c.1270G>T	c.(1270-1272)GGC>TGC	p.G424C	EPB42_uc001zqz.3_Missense_Mutation_p.G91C|EPB42_uc010bde.2_Missense_Mutation_p.G269C|EPB42_uc001zrb.3_Missense_Mutation_p.G454C|EPB42_uc010udm.1_Missense_Mutation_p.G346C	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	424					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		CGGTCACTGCCCACACCCTTG	0.552													A	43499445	A	A	43499445	3	1	32	1	0	0	0	0	1	0	0	0	5158	623	22	5	825	5	EPB42	15	43499445	Missense_Mutation	SNP	C	TCGA-06-0168-01A-01D-1491-08		43499445	59031947	48	1982											
SMAD3	4088	broad.mit.edu	37	chr15	67457245	67457245	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggcaggtccctggatggCcggttgcaggtgtcccatcg	15	13	0	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr15:67457245C>T	uc002aqj.2	+	2	517	c.219C>T	c.(217-219)GGC>GGT	p.G73G	SMAD3_uc010ujr.1_5'UTR|SMAD3_uc010ujs.1_Silent_p.G29G|SMAD3_uc010ujt.1_5'Flank	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	73	MH1.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CCCTGGATGGCCGGTTGCAGG	0.612													T	67457245	T	T	67457245	2	4	32	1	0	0	0	0	0	0	0	1	14759	726	26	3		3	SMAD3	15	67457245	Silent	SNP	C	TCGA-06-0168-01A-01D-1491-08	23957800	67457245	35074147	49	1983											
CACNA1G	8913	broad.mit.edu	37	chr17	48697121	48697121	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaagctgatggacgagctGgcaggcccagggggccagcc	17	12	0	2			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr17:48697121G>A	uc002irk.1	+	34	6231	c.5859G>A	c.(5857-5859)CTG>CTA	p.L1953L	CACNA1G_uc002irj.1_Intron|CACNA1G_uc002irl.1_Intron|CACNA1G_uc002irm.1_Silent_p.L1919L|CACNA1G_uc002irn.1_Intron|CACNA1G_uc002iro.1_Intron|CACNA1G_uc002irp.1_Silent_p.L1953L|CACNA1G_uc002irq.1_Silent_p.L1930L|CACNA1G_uc002irr.1_Intron|CACNA1G_uc002irs.1_Silent_p.L1942L|CACNA1G_uc002irt.1_Intron|CACNA1G_uc002irv.1_Intron|CACNA1G_uc002irw.1_Intron|CACNA1G_uc002iru.1_Silent_p.L1919L|CACNA1G_uc002irx.1_Intron|CACNA1G_uc002iry.1_Intron|CACNA1G_uc002irz.1_Intron|CACNA1G_uc002isa.1_Intron|CACNA1G_uc002isb.1_Intron|CACNA1G_uc002isc.1_Silent_p.L1855L|CACNA1G_uc002isd.1_Intron|CACNA1G_uc002ise.1_Silent_p.L1821L|CACNA1G_uc002isf.1_Silent_p.L1848L|CACNA1G_uc002isg.1_Intron|CACNA1G_uc002ish.1_Intron|CACNA1G_uc002isi.1_Intron	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1953	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGGACGAGCTGGCAGGCCCAG	0.667													A	48697121	A	A	48697121	2	1	32	1	0	0	0	0	0	0	0	1	2544	1335	47	3		3	CACNA1G	17	48697121	Silent	SNP	G	TCGA-06-0168-01A-01D-1491-08		48697121	32498089	50	1984											
KIAA0427	9811	broad.mit.edu	37	chr18	46385757	46385757	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggaggaacagctgcctgagAtgatgacagagctcctggcc	14	10	0	4			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr18:46385757A>G	uc002ldc.2	+	12	1909	c.1624A>G	c.(1624-1626)ATG>GTG	p.M542V	KIAA0427_uc002ldd.2_Missense_Mutation_p.M544V|KIAA0427_uc002lde.3_Missense_Mutation_p.M171V	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	542	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0						GCTGCCTGAGATGATGACAGA	0.637													G	46385757	G	G	46385757	3	3	32	1	0	0	0	0	1	0	0	0	8176	333	12	4	1672	4	KIAA0427	18	46385757	Missense_Mutation	SNP	A	TCGA-06-0168-01A-01D-1491-08		46385757	31691491	51	1985											
DNMT1	1786	broad.mit.edu	37	chr19	10254528	10254528	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaagatctctttgatccgGccaattcggtagggctcagg	12	10	2	3			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr19:10254528G>A	uc002mng.2	-	28	3162	c.2982C>T	c.(2980-2982)GGC>GGT	p.G994G	DNMT1_uc002mnf.2_5'UTR|DNMT1_uc010xlc.1_Silent_p.G1010G|DNMT1_uc002mnh.2_Silent_p.G889G|DNMT1_uc010xld.1_Silent_p.G994G	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	994	BAH 2.				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CTTTGATCCGGCCAATTCGGT	0.542													A	10254528	A	A	10254528	2	1	32	1	0	0	0	0	0	0	0	1	4675	1190	42	3		3	DNMT1	19	10254528	Silent	SNP	G	TCGA-06-0168-01A-01D-1491-08		10254528	48874455	52	1986											
CRLF1	9244	broad.mit.edu	37	chr19	18710416	18710416	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagccaggatgctgccgtcaCgggcgtggcacacgaggttg	16	12	1	0	rs146027258	byFrequency	TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr19:18710416C>T	uc010ebt.1	-	2	550	c.356G>A	c.(355-357)CGT>CAT	p.R119H		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	119	Ig-like C2-type.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity	p.R119H(1)		central_nervous_system(1)	1						GCTGCCGTCACGGGCGTGGCA	0.652													T	18710416	T	T	18710416	3	4	32	1	0	0	0	0	1	0	0	0	3886	536	19	1	944	1	CRLF1	19	18710416	Missense_Mutation	SNP	C	TCGA-06-0168-01A-01D-1491-08	8455888	18710416	40418567	53	1987											
FOSB	2354	broad.mit.edu	37	chr19	45973902	45973902	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtaggagtgcgccggtctcGgggaaatgcccggttccttc	15	12	1	0			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr19:45973902G>A	uc002pbx.3	+	2	734	c.142G>A	c.(142-144)GGG>AGG	p.G48R	ERCC1_uc002pbu.1_Intron|FOSB_uc002pbw.2_Missense_Mutation_p.G48R|FOSB_uc010eke.2_Intron|FOSB_uc002pby.3_Missense_Mutation_p.G48R|FOSB_uc010eka.1_Intron|FOSB_uc010ekb.1_Missense_Mutation_p.G48R|FOSB_uc010ekc.1_Intron|FOSB_uc010ekf.2_Intron|FOSB_uc010ekd.1_Missense_Mutation_p.G48R|FOSB_uc010ekg.2_Intron|FOSB_uc002pca.3_5'UTR	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	48					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		CGCCGGTCTCGGGGAAATGCC	0.408													A	45973902	A	A	45973902	3	1	32	1	0	0	0	0	1	0	0	0	5986	1116	39	2	148	2	FOSB	19	45973902	Missense_Mutation	SNP	G	TCGA-06-0168-01A-01D-1491-08	27263486	45973902	13155081	54	1988											
PNMAL2	57469	broad.mit.edu	37	chr19	46997949	46997949	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcttcgatttgtcggtgacGgtgaccagagccaagaactc	11	10	1	4			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr19:46997949G>A	uc002pes.2	-	1	1221	c.774C>T	c.(772-774)ACC>ACT	p.T258T	uc002peu.1_Silent_p.T20T	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	258										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TGTCGGTGACGGTGACCAGAG	0.602													A	46997949	A	A	46997949	2	1	32	1	0	0	0	0	0	0	0	1	12158	1103	39	2		2	PNMAL2	19	46997949	Silent	SNP	G	TCGA-06-0168-01A-01D-1491-08	1024047	46997949	12131034	55	1989											
DHX34	9704	broad.mit.edu	37	chr19	47883014	47883014	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacaccaatggtgactgctcCcgcctggtggccgatggctg	14	13	0	1			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chr19:47883014C>T	uc010xyn.1	+	14	3095	c.2754C>T	c.(2752-2754)TCC>TCT	p.S918S	DHX34_uc010xyo.1_Silent_p.S47S	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	918						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GTGACTGCTCCCGCCTGGTGG	0.627													T	47883014	T	T	47883014	2	4	32	1	0	0	0	0	0	0	0	1	4507	610	22	3		3	DHX34	19	47883014	Silent	SNP	C	TCGA-06-0168-01A-01D-1491-08	885065	47883014	11245969	56	1990											
GPRASP2	114928	broad.mit.edu	37	chrX	101972203	101972203	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgtccttaattgatgatgaTttcagtcttgagccgcttat	8	7	2	4			TCGA-06-0168-01A-01D-1491-08	TCGA-06-0168-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2b3bab1e-dddd-4c2c-b5ec-7bb6e700e070	5901ecf0-7e6a-410c-b491-ae958d77f1f3	g.chrX:101972203T>C	uc004ejk.2	+	4	3740	c.2406T>C	c.(2404-2406)GAT>GAC	p.D802D	GPRASP2_uc004ejl.2_Silent_p.D802D|GPRASP2_uc004ejm.2_Silent_p.D802D|GPRASP2_uc011mrp.1_Silent_p.D141D	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	802						cytoplasm	protein binding			ovary(1)	1						TTGATGATGATTTCAGTCTTG	0.333													C	101972203	C	C	101972203	2	2	32	1	0	0	0	0	0	0	0	1	6723	1490	52	4		4	GPRASP2	23	101972203	Silent	SNP	T	TCGA-06-0168-01A-01D-1491-08		101972203	53298357	57	1991											
PRAMEF12	390999	broad.mit.edu	37	chr1	12836029	12836029	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtatccaggaggtggaagtgTgctgcccgtgggagctgtcc	17	9	0	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr1:12836029T>C	uc001aui.2	+	2	658	c.631T>C	c.(631-633)TGC>CGC	p.C211R		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	211										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGGAAGTGTGCTGCCCGTG	0.517													C	12836029	C	C	12836029	3	2	33	1	0	0	0	0	1	0	0	0	12428	1696	59	4	637	4	PRAMEF12	1	12836029	Missense_Mutation	SNP	T	TCGA-06-0169-01A-01D-1490-08		12836029	236414592	1	1992											
SGIP1	84251	broad.mit.edu	37	chr1	67133216	67133216	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttttgctgatcacagaggCgcagcccggtaagaactctc	10	12	2	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr1:67133216C>T	uc001dcr.2	+	9	692	c.475C>T	c.(475-477)CGC>TGC	p.R159C	SGIP1_uc010opd.1_5'UTR|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|uc010ope.1_Intron	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	159					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						ATCACAGAGGCGCAGCCCGGT	0.418													T	67133216	T	T	67133216	3	4	33	1	0	0	0	0	1	0	0	0	14206	768	27	1	509	1	SGIP1	1	67133216	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	54297187	67133216	182117405	2	1993											
GBP1	2633	broad.mit.edu	37	chr1	89521850	89521850	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgaagtaaagctgagcaaCgatctgatgatgcttcctga	10	9	1	5	rs140785577		TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr1:89521850C>T	uc001dmx.2	-	8	1437	c.1217G>A	c.(1216-1218)CGT>CAT	p.R406H		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	406					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		AGCTGAGCAACGATCTGATGA	0.408													T	89521850	T	T	89521850	3	4	33	1	0	0	0	0	1	0	0	0	6273	536	19	1	577	1	GBP1	1	89521850	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	22388634	89521850	159728771	3	1994											
HRNR	388697	broad.mit.edu	37	chr1	152188002	152188002	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctggaagactgacctgagcTagctccatgttggccacagc	12	12	0	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr1:152188002T>C	uc001ezt.1	-	3	6179	c.6103A>G	c.(6103-6105)AGC>GGC	p.S2035G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2035	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCTGAGCTAGCTCCATGT	0.567													C	152188002	C	C	152188002	3	2	33	1	0	0	0	0	1	0	0	0	7359	1522	53	4	2453	4	HRNR	1	152188002	Missense_Mutation	SNP	T	TCGA-06-0169-01A-01D-1490-08	62666152	152188002	97062619	4	1995											
BCAN	63827	broad.mit.edu	37	chr1	156617796	156617796	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatcccatccagaccccacgAgaggcctgttacggagacat	9	14	0	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr1:156617796A>G	uc001fpp.2	+	5	999	c.663A>G	c.(661-663)CGA>CGG	p.R221R	BCAN_uc001fpo.2_Silent_p.R221R	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	221	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGACCCCACGAGAGGCCTGTT	0.532													G	156617796	G	G	156617796	2	3	33	1	0	0	0	0	0	0	0	1	1345	291	11	4		4	BCAN	1	156617796	Silent	SNP	A	TCGA-06-0169-01A-01D-1490-08	4429794	156617796	92632825	5	1996											
PYHIN1	149628	broad.mit.edu	37	chr1	158914718	158914718	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tccaggagcatggcactaccCcaggaacagagtcagcatcc	10	14	1	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr1:158914718C>A	uc001ftb.2	+	7	1490	c.1245C>A	c.(1243-1245)CCC>CCA	p.P415P	PYHIN1_uc001ftc.2_Silent_p.P406P|PYHIN1_uc001ftd.2_Silent_p.P415P|PYHIN1_uc001fte.2_Silent_p.P406P	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	415					cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					TGGCACTACCCCAGGAACAGA	0.433													A	158914718	A	A	158914718	2	1	33	1	0	0	0	0	0	0	0	1	12865	610	22	5		5	PYHIN1	1	158914718	Silent	SNP	C	TCGA-06-0169-01A-01D-1490-08	2296922	158914718	90335903	6	1997											
OR2T6	254879	broad.mit.edu	37	chr1	248551593	248551593	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ctcatcacagtgcatcagatGacatcggctgaagggaggaa	12	9	3	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr1:248551593G>T	uc001iei.1	+	1	684	c.684G>T	c.(682-684)ATG>ATT	p.M228I		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGCATCAGATGACATCGGCTG	0.502													T	248551593	T	T	248551593	3	4	33	1	0	0	0	0	1	0	0	0	11029	1290	45	5	686	5	OR2T6	1	248551593	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08	89636875	248551593	699028	7	1998											
ANKRD53	79998	broad.mit.edu	37	chr2	71209104	71209104	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgcccctgcacctggcagCccgtgacggcttgctggact	12	17	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr2:71209104C>T	uc002shl.3	+	4	857	c.656C>T	c.(655-657)GCC>GTC	p.A219V	ANKRD53_uc002shk.3_Missense_Mutation_p.A219V|ANKRD53_uc002shm.3_Intron	NM_001115116	NP_001108588	Q8N9V6	ANR53_HUMAN	ankyrin repeat domain 53 isoform a	219	ANK 3.										0						CACCTGGCAGCCCGTGACGGC	0.577													T	71209104	T	T	71209104	3	4	33	1	0	0	0	0	1	0	0	0	679	739	26	3	670	3	ANKRD53	2	71209104	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08		71209104	171990269	8	1999											
DYSF	8291	broad.mit.edu	37	chr2	71871138	71871138	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagcaaattctttgcctccaTaggggagagggaaaagtgcg	14	7	1	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr2:71871138T>C	uc002sie.2	+	41	4830	c.4454T>C	c.(4453-4455)ATA>ACA	p.I1485T	DYSF_uc010feg.2_Missense_Mutation_p.I1516T|DYSF_uc010feh.2_Missense_Mutation_p.I1492T|DYSF_uc002sig.3_Missense_Mutation_p.I1471T|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.I1506T|DYSF_uc010fef.2_Missense_Mutation_p.I1523T|DYSF_uc010fei.2_Missense_Mutation_p.I1502T|DYSF_uc010fek.2_Missense_Mutation_p.I1503T|DYSF_uc010fej.2_Missense_Mutation_p.I1493T|DYSF_uc010fel.2_Missense_Mutation_p.I1472T|DYSF_uc010feo.2_Missense_Mutation_p.I1517T|DYSF_uc010fem.2_Missense_Mutation_p.I1507T|DYSF_uc010fen.2_Missense_Mutation_p.I1524T|DYSF_uc002sif.2_Missense_Mutation_p.I1486T|DYSF_uc010yqy.1_Missense_Mutation_p.I366T|DYSF_uc010yqz.1_Missense_Mutation_p.I246T	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1485	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TTTGCCTCCATAGGGGAGAGG	0.502													C	71871138	C	C	71871138	3	2	33	1	0	0	0	0	1	0	0	0	4859	1406	49	4	4875	4	DYSF	2	71871138	Missense_Mutation	SNP	T	TCGA-06-0169-01A-01D-1490-08	662034	71871138	171328235	9	2000											
FAM123C	205147	broad.mit.edu	37	chr2	131521578	131521578	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccctgctcccagaaggagCctgggccaccaggggtcctg	15	15	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr2:131521578C>T	uc002trw.2	+	2	2123	c.1933C>T	c.(1933-1935)CCT>TCT	p.P645S	FAM123C_uc010fmv.2_Missense_Mutation_p.P645S|FAM123C_uc010fms.1_Missense_Mutation_p.P645S|FAM123C_uc010fmt.1_Missense_Mutation_p.P645S|FAM123C_uc010fmu.1_Missense_Mutation_p.P645S	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	645										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CCAGAAGGAGCCTGGGCCACC	0.602													T	131521578	T	T	131521578	3	4	33	1	0	0	0	0	1	0	0	0	5424	739	26	3	1935	3	FAM123C	2	131521578	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	59650440	131521578	111677795	10	2001											
SCN9A	6335	broad.mit.edu	37	chr2	167085307	167085307	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taagggcaaaacattcggaaCgatttggaacttgacttgca	10	7	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr2:167085307C>T	uc010fpl.2	-	22	4408	c.4067G>A	c.(4066-4068)CGT>CAT	p.R1356H	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1367	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ACATTCGGAACGATTTGGAAC	0.398													T	167085307	T	T	167085307	3	4	33	1	0	0	0	0	1	0	0	0	13925	536	19	1	1890	1	SCN9A	2	167085307	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	35563729	167085307	76114066	11	2002											
HDLBP	3069	broad.mit.edu	37	chr2	242173290	242173290	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcacgtcatgctccaaccggAtttgggtaattactgccccc	8	14	2	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr2:242173290A>G	uc002waz.2	-	24	3461	c.3233T>C	c.(3232-3234)ATC>ACC	p.I1078T	HDLBP_uc002wba.2_Missense_Mutation_p.I1078T|HDLBP_uc002wbb.2_Missense_Mutation_p.I1030T	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	1078	KH 13.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CTCCAACCGGATTTGGGTAAT	0.498													G	242173290	G	G	242173290	3	3	33	1	0	0	0	0	1	0	0	0	7025	333	12	4	593	4	HDLBP	2	242173290	Missense_Mutation	SNP	A	TCGA-06-0169-01A-01D-1490-08	75087983	242173290	1026083	12	2003											
CCK	885	broad.mit.edu	37	chr3	42305011	42305011	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagctgcctacggggcgcctCctctgcccgctgcagcccgg	13	19	1	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr3:42305011C>T	uc003clc.1	-	2	321	c.112G>A	c.(112-114)GAG>AAG	p.E38K	CCK_uc003cld.1_Missense_Mutation_p.E38K|CCK_uc011azk.1_Missense_Mutation_p.E38K	NM_000729	NP_000720	P06307	CCKN_HUMAN	cholecystokinin preproprotein	38					axonogenesis|eating behavior|neuron migration		neuropeptide hormone activity	p.E38K(1)		central_nervous_system(1)	1		Ovarian(412;0.0728)		KIRC - Kidney renal clear cell carcinoma(284;0.219)		CGGGGCGCCTCCTCTGCCCGC	0.711													T	42305011	T	T	42305011	3	4	33	1	0	0	0	0	1	0	0	0	2879	864	30	3	243	3	CCK	3	42305011	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08		42305011	155717419	13	2004											
MANF	7873	broad.mit.edu	37	chr3	51425306	51425306	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccagatatgtgagcttaagTatggtgagtatgcctagtcc	12	7	0	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr3:51425306T>C	uc003dbc.2	+	3	432	c.370T>C	c.(370-372)TAT>CAT	p.Y124H		NM_006010	NP_006001	P55145	MANF_HUMAN	mesencephalic astrocyte-derived neurotrophic	121					response to unfolded protein	extracellular region	growth factor activity				0						TGAGCTTAAGTATGGTGAGTA	0.458													C	51425306	C	C	51425306	3	2	33	1	0	0	0	0	1	0	0	0	9223	1638	57	4	380	4	MANF	3	51425306	Missense_Mutation	SNP	T	TCGA-06-0169-01A-01D-1490-08	9120295	51425306	146597124	14	2005											
DKK2	27123	broad.mit.edu	37	chr4	107847047	107847047	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atgcaggccgatgatccttgGtggggactgtggcaatacct	14	9	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr4:107847047G>T	uc003hyi.2	-	2	987	c.282C>A	c.(280-282)CAC>CAA	p.H94Q	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Missense_Mutation_p.H94Q	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	94	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		ATGATCCTTGGTGGGGACTGT	0.502													T	107847047	T	T	107847047	3	4	33	1	0	0	0	0	1	0	0	0	4545	1252	44	5	509	5	DKK2	4	107847047	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08		107847047	83307229	15	2006											
DCHS2	54798	broad.mit.edu	37	chr4	155305544	155305544	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttccttcactggttttgcGttctcttcctggcttctgaa	8	11	3	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr4:155305544G>A	uc003inw.2	-	2	210	c.210C>T	c.(208-210)AAC>AAT	p.N70N	DCHS2_uc003inx.2_Intron	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	70	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ctggttttgcgttctcttcct	0.01													A	155305544	A	A	155305544	2	1	33	1	0	0	0	0	0	0	0	1	4288	1136	40	1		1	DCHS2	4	155305544	Silent	SNP	G	TCGA-06-0169-01A-01D-1490-08	47458497	155305544	35848732	16	2007											
ODZ3	55714	broad.mit.edu	37	chr4	183713527	183713527	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccagtgtggctcgccacaCcatgcagaccatccgatcca	9	17	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr4:183713527C>T	uc003ivd.1	+	25	5739	c.5702C>T	c.(5701-5703)ACC>ATC	p.T1901I		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1901	YD 7.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GCTCGCCACACCATGCAGACC	0.547													T	183713527	T	T	183713527	3	4	33	1	0	0	0	0	1	0	0	0	10836	507	18	3	5800	3	ODZ3	4	183713527	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	28407983	183713527	7440749	17	2008											
GPR98	84059	broad.mit.edu	37	chr5	89969926	89969926	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaacttaatgagtatttccGtgtgacattggtttctgcaa	9	6	1	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr5:89969926G>A	uc003kju.2	+	23	5081	c.4985G>A	c.(4984-4986)CGT>CAT	p.R1662H	GPR98_uc003kjt.2_Translation_Start_Site|GPR98_uc010jba.1_RNA	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1662	Calx-beta 11.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GAGTATTTCCGTGTGACATTG	0.393													A	89969926	A	A	89969926	3	1	33	1	0	0	0	0	1	0	0	0	6721	1145	40	1	5075	1	GPR98	5	89969926	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08		89969926	90945334	18	2009											
PCDHB9	56127	broad.mit.edu	37	chr5	140568233	140568233	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctccgacgtcaatgacaacGcccccgccttcacccaaacc	5	20	3	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr5:140568233G>A	uc003liw.1	+	3	1342	c.1342G>A	c.(1342-1344)GCC>ACC	p.A448T		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	448	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATGACAACGCCCCCGCCTT	0.592													A	140568233	A	A	140568233	3	1	33	1	0	0	0	0	1	0	0	0	11549	1074	38	1	1343	1	PCDHB9	5	140568233	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08	50598307	140568233	40347027	19	2010											
FAT2	2196	broad.mit.edu	37	chr5	150923883	150923883	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caattgggaaaaagtgggagGgttatcattgacatcctcca	11	7	1	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr5:150923883G>T	uc003lue.3	-	9	6818	c.6805C>A	c.(6805-6807)CCT>ACT	p.P2269T	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2269	Cadherin 19.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAGTGGGAGGGTTATCATTG	0.502													T	150923883	T	T	150923883	3	4	33	1	0	0	0	0	1	0	0	0	5690	1232	43	5	6304	5	FAT2	5	150923883	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08	10355650	150923883	29991377	20	2011											
FAM71B	153745	broad.mit.edu	37	chr5	156592924	156592924	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggttgggccagaaccatgaCgtcaggcagtgggaggatgg	18	7	1	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr5:156592924C>T	uc003lwn.2	-	1	356	c.256G>A	c.(256-258)GTC>ATC	p.V86I		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	86						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAACCATGACGTCAGGCAGT	0.542													T	156592924	T	T	156592924	3	4	33	1	0	0	0	0	1	0	0	0	5608	536	19	1	1569	1	FAM71B	5	156592924	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	5669041	156592924	24322336	21	2012											
HLA-B	3106	broad.mit.edu	37	chr6	31322411	31322411	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccacccccaccacttacaCgcagcctgagagtagctccc	6	20	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr6:31322411C>T	uc003nth.2	-	6	1098	c.1044G>A	c.(1042-1044)GCG>GCA	p.A348A	HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Silent_p.A227A|HLA-B_uc003nti.1_RNA	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	348	Cytoplasmic (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						ACCACTTACACGCAGCCTGAG	0.572									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				T	31322411	T	T	31322411	2	4	33	1	0	0	0	0	0	0	0	1	7196	550	19	1		1	HLA-B	6	31322411	Silent	SNP	C	TCGA-06-0169-01A-01D-1490-08		31322411	139792656	22	2013											
TRAM2	9697	broad.mit.edu	37	chr6	52370483	52370483	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaaagccaatggccagcacGgcaagggtgaggatgaagag	15	9	0	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr6:52370483G>A	uc003paq.2	-	9	938	c.789C>T	c.(787-789)GCC>GCT	p.A263A	EFHC1_uc011dwv.1_Intron|TRAM2_uc003par.1_RNA	NM_012288	NP_036420	Q15035	TRAM2_HUMAN	translocation-associated membrane protein 2	263	TLC.|Helical; (Potential).				collagen biosynthetic process|protein transport|transmembrane transport	integral to membrane	protein binding				0	Lung NSC(77;0.109)					TGGCCAGCACGGCAAGGGTGA	0.542													A	52370483	A	A	52370483	2	1	33	1	0	0	0	0	0	0	0	1	16450	1103	39	2		2	TRAM2	6	52370483	Silent	SNP	G	TCGA-06-0169-01A-01D-1490-08	21048072	52370483	118744584	23	2014											
TCP10	6953	broad.mit.edu	37	chr6	167790118	167790118	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctgtcttgacgtctcccGggaggacttttctctctatc	8	13	5	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr6:167790118G>A	uc003qvv.1	-	5	704	c.492C>T	c.(490-492)CCC>CCT	p.P164P	TCP10_uc003qvu.2_Silent_p.P164P|TCP10_uc003qvw.2_Silent_p.P140P	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	191						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		GACGTCTCCCGGGAGGACTTT	0.493													A	167790118	A	A	167790118	2	1	33	1	0	0	0	0	0	0	0	1	15707	1103	39	2		2	TCP10	6	167790118	Silent	SNP	G	TCGA-06-0169-01A-01D-1490-08	115419635	167790118	3324949	24	2015											
NXPH1	30010	broad.mit.edu	37	chr7	8791118	8791118	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaatcgtggaatttgacttgGcacaacaaaccgtgattgat	9	7	0	3	rs145299363	by1000genomes	TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr7:8791118G>C	uc003srv.2	+	3	1446	c.535G>C	c.(535-537)GCA>CCA	p.A179P	NXPH1_uc011jxh.1_Missense_Mutation_p.A62P	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	179	IV (linker domain).					extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		ATTTGACTTGGCACAACAAAC	0.398													C	8791118	C	C	8791118	3	2	33	1	0	0	0	0	1	0	0	0	10790	1203	42	5	541	5	NXPH1	7	8791118	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08		8791118	150347545	25	2016											
THSD7A	221981	broad.mit.edu	37	chr7	11422186	11422186	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgacctttgacaccacactGttcgggaagagcccttccaa	8	14	0	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr7:11422186G>A	uc003ssf.3	-	23	4721	c.4469C>T	c.(4468-4470)ACA>ATA	p.T1490I	uc003ssb.2_Intron|THSD7A_uc003ssd.3_5'Flank	NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1490	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ACACCACACTGTTCGGGAAGA	0.418										HNSCC(18;0.044)			A	11422186	A	A	11422186	3	1	33	1	0	0	0	0	1	0	0	0	15876	1377	48	3	524	3	THSD7A	7	11422186	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08	2631068	11422186	147716477	26	2017											
DNAH11	8701	broad.mit.edu	37	chr7	21599234	21599234	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttgtaggccaccgtcaaacGaaaggataatacttcatgca	8	9	2	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr7:21599234G>A	uc003svc.2	+	4	737	c.706G>A	c.(706-708)GAA>AAA	p.E236K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	236	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ACCGTCAAACGAAAGGATAAT	0.313									Kartagener_syndrome				A	21599234	A	A	21599234	3	1	33	1	0	0	0	0	1	0	0	0	4599	1059	37	2	720	2	DNAH11	7	21599234	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08	10177048	21599234	137539429	27	2018											
GRB10	2887	broad.mit.edu	37	chr7	50742172	50742172	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caggctgggagcgctgcaccCtctgcctcggggacacctgt	14	15	1	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr7:50742172C>G	uc003tpi.2	-	3	354	c.323G>C	c.(322-324)AGG>ACG	p.R108T	GRB10_uc003tph.3_Missense_Mutation_p.R50T|GRB10_uc003tpj.2_Missense_Mutation_p.R108T|GRB10_uc003tpk.2_Missense_Mutation_p.R108T|GRB10_uc010kzb.2_Missense_Mutation_p.R50T|GRB10_uc003tpl.2_Missense_Mutation_p.R102T|GRB10_uc003tpm.2_Missense_Mutation_p.R50T|GRB10_uc003tpn.2_Missense_Mutation_p.R50T	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	108					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					GCGCTGCACCCTCTGCCTCGG	0.657									Russell-Silver_syndrome				G	50742172	G	G	50742172	3	3	33	1	0	0	0	0	1	0	0	0	6756	681	24	5	1517	5	GRB10	7	50742172	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	29142938	50742172	108396491	28	2019											
PCLO	27445	broad.mit.edu	37	chr7	82763793	82763793	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttaataggtggtggcttttTttctgtttctgttcttttta	8	5	3	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr7:82763793T>C	uc003uhx.2	-	3	3362	c.3073A>G	c.(3073-3075)AAA>GAA	p.K1025E	PCLO_uc003uhv.2_Missense_Mutation_p.K1025E	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	971	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGTGGCTTTTTTTCTGTTTCT	0.408													C	82763793	C	C	82763793	3	2	33	1	0	0	0	0	1	0	0	0	11583	1850	64	4	12464	4	PCLO	7	82763793	Missense_Mutation	SNP	T	TCGA-06-0169-01A-01D-1490-08	32021621	82763793	76374870	29	2020											
RELN	5649	broad.mit.edu	37	chr7	103270455	103270455	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatcccagagactgagtgacCtccacaagattggtaaagtc	9	10	0	4			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr7:103270455C>T	uc003vca.2	-	20	2794	c.2634G>A	c.(2632-2634)GAG>GAA	p.E878E	RELN_uc010liz.2_Silent_p.E878E	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	878					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACTGAGTGACCTCCACAAGAT	0.408													T	103270455	T	T	103270455	2	4	33	1	0	0	0	0	0	0	0	1	13220	680	24	3		3	RELN	7	103270455	Silent	SNP	C	TCGA-06-0169-01A-01D-1490-08	20506662	103270455	55868208	30	2021											
TAS2R39	259285	broad.mit.edu	37	chr7	142881262	142881262	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcaatgccacagggtccaacGaccccagcatggaggctcac	11	15	1	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr7:142881262G>A	uc011ksw.1	+	1	751	c.751G>A	c.(751-753)GAC>AAC	p.D251N		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	251	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					AGGGTCCAACGACCCCAGCAT	0.498													A	142881262	A	A	142881262	3	1	33	1	0	0	0	0	1	0	0	0	15573	1058	37	2	753	2	TAS2R39	7	142881262	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08	39610807	142881262	16257401	31	2022											
OR2A5	393046	broad.mit.edu	37	chr7	143748162	143748162	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctactcgcgcatcctggCggccatcttgaggatccagt	10	15	1	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr7:143748162C>T	uc011ktw.1	+	1	668	c.668C>T	c.(667-669)GCG>GTG	p.A223V		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					CGCATCCTGGCGGCCATCTTG	0.607													T	143748162	T	T	143748162	3	4	33	1	0	0	0	0	1	0	0	0	10981	768	27	1	670	1	OR2A5	7	143748162	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	866900	143748162	15390501	32	2023											
TEX15	56154	broad.mit.edu	37	chr8	30695500	30695500	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatttcaaccttttttggcGttaaatgatttcttttcaga	6	7	3	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr8:30695500G>A	uc003xil.2	-	3	7151	c.7151C>T	c.(7150-7152)ACG>ATG	p.T2384M		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2384										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTTTTTTGGCGTTAAATGATT	0.388													A	30695500	A	A	30695500	3	1	33	1	0	0	0	0	1	0	0	0	15776	1145	40	1	1226	1	TEX15	8	30695500	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08		30695500	115668522	33	2024											
ADAM18	8749	broad.mit.edu	37	chr8	39502901	39502901	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggattttcggttattatagcTcaactgcttggccttaatgt	9	7	1	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr8:39502901T>C	uc003xni.2	+	11	954	c.954T>C	c.(952-954)GCT>GCC	p.A318A	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Silent_p.A294A	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	318	Peptidase M12B.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TTATTATAGCTCAACTGCTTG	0.333													C	39502901	C	C	39502901	2	2	33	1	0	0	0	0	0	0	0	1	239	1538	54	4		4	ADAM18	8	39502901	Silent	SNP	T	TCGA-06-0169-01A-01D-1490-08	8807401	39502901	106861121	34	2025											
IL7	3574	broad.mit.edu	37	chr8	79710323	79710323	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataccaataattgatcgatgCtgaccattagaacactctca	5	10	1	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr8:79710323C>T	uc003ybg.2	-	2	732	c.131G>A	c.(130-132)AGC>AAC	p.S44N	IL7_uc003ybe.2_Missense_Mutation_p.S3N|IL7_uc011lfm.1_RNA|IL7_uc003ybh.2_Intron|IL7_uc003ybi.3_RNA	NM_000880	NP_000871	P13232	IL7_HUMAN	interleukin 7 precursor	44					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding				0						TTGATCGATGCTGACCATTAG	0.353													T	79710323	T	T	79710323	3	4	33	1	0	0	0	0	1	0	0	0	7704	797	28	3	422	3	IL7	8	79710323	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	40207422	79710323	66653699	35	2026											
GPR20	2843	broad.mit.edu	37	chr8	142366995	142366995	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggtgagggcgtgagggccGgcactgaggatgtgatgacg	21	6	0	5			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr8:142366995G>A	uc003ywf.2	-	2	1118	c.1029C>T	c.(1027-1029)GCC>GCT	p.A343A		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	343	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CGTGAGGGCCGGCACTGAGGA	0.667													A	142366995	A	A	142366995	2	1	33	1	0	0	0	0	0	0	0	1	6680	1103	39	2		2	GPR20	8	142366995	Silent	SNP	G	TCGA-06-0169-01A-01D-1490-08	62656672	142366995	3997027	36	2027											
C9orf131	138724	broad.mit.edu	37	chr9	35045456	35045456	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagcctcatcctcagccaaaAagagagagcaccctaggaaa	8	13	2	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr9:35045456A>G	uc003zvw.2	+	2	2859	c.2830A>G	c.(2830-2832)AAG>GAG	p.K944E	C9orf131_uc003zvu.2_Missense_Mutation_p.K896E|C9orf131_uc003zvv.2_Missense_Mutation_p.K871E|C9orf131_uc003zvx.2_Missense_Mutation_p.K909E	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	944											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CTCAGCCAAAAAGAGAGAGCA	0.532													G	35045456	G	G	35045456	3	3	33	1	0	0	0	0	1	0	0	0	2457	15	1	4	2852	4	C9orf131	9	35045456	Missense_Mutation	SNP	A	TCGA-06-0169-01A-01D-1490-08		35045456	106167975	37	2028											
COL15A1	1306	broad.mit.edu	37	chr9	101797331	101797331	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggcttacctggacccccGgggaaaaagggacaagctgg	15	10	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr9:101797331G>A	uc004azb.1	+	18	2321	c.2115G>A	c.(2113-2115)CCG>CCA	p.P705P		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	705	Triple-helical region 2 (COL2).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				CTGGACCCCCGGGGAAAAAGG	0.612													A	101797331	A	A	101797331	2	1	33	1	0	0	0	0	0	0	0	1	3672	1103	39	2		2	COL15A1	9	101797331	Silent	SNP	G	TCGA-06-0169-01A-01D-1490-08	66751875	101797331	39416100	38	2029											
ANO9	338440	broad.mit.edu	37	chr11	420522	420522	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accagaccatcttgatggcgTccaggcggatctccacgagg	12	13	2	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr11:420522T>C	uc001lpi.2	-	19	1812	c.1727A>G	c.(1726-1728)GAC>GGC	p.D576G	ANO9_uc001lph.2_Missense_Mutation_p.D269G|ANO9_uc010qvv.1_Missense_Mutation_p.D432G	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	576	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CTTGATGGCGTCCAGGCGGAT	0.687													C	420522	C	C	420522	3	2	33	1	0	0	0	0	1	0	0	0	704	1667	58	4	641	4	ANO9	11	420522	Missense_Mutation	SNP	T	TCGA-06-0169-01A-01D-1490-08		420522	134585994	39	2030											
OR51L1	119682	broad.mit.edu	37	chr11	5020398	5020398	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctctccatcagcccatgtaTtactttatttccatcttagc	3	13	3	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr11:5020398T>C	uc010qyu.1	+	1	186	c.186T>C	c.(184-186)TAT>TAC	p.Y62Y		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCCCATGTATTACTTTATTT	0.448													C	5020398	C	C	5020398	2	2	33	1	0	0	0	0	0	0	0	1	11102	1500	52	4		4	OR51L1	11	5020398	Silent	SNP	T	TCGA-06-0169-01A-01D-1490-08	4599876	5020398	129986118	40	2031											
LYVE1	10894	broad.mit.edu	37	chr11	10580685	10580685	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagcttccaggcatcgcacGgtagttttgcttggactctt	10	11	2	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr11:10580685G>A	uc001miv.2	-	6	1228	c.942C>T	c.(940-942)ACC>ACT	p.T314T	uc001miu.2_Intron|LYVE1_uc010rca.1_Silent_p.T210T	NM_006691	NP_006682	Q9Y5Y7	LYVE1_HUMAN	lymphatic vessel endothelial hyaluronan receptor	314	Cytoplasmic (Potential).				anatomical structure morphogenesis|cell-matrix adhesion|cellular component movement|response to wounding|transport	integral to plasma membrane|membrane fraction		p.T314T(1)		central_nervous_system(1)|skin(1)	2				all cancers(16;7.22e-08)|Epithelial(150;1.03e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0609)		GGCATCGCACGGTAGTTTTGC	0.463													A	10580685	A	A	10580685	2	1	33	1	0	0	0	0	0	0	0	1	9129	1103	39	2		2	LYVE1	11	10580685	Silent	SNP	G	TCGA-06-0169-01A-01D-1490-08	5560287	10580685	124425831	41	2032											
MRGPRX1	259249	broad.mit.edu	37	chr11	18955854	18955854	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actgaacaggaagccacataAcatccactccaggatgctcc	7	14	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr11:18955854A>C	uc001mpg.2	-	1	696	c.478T>G	c.(478-480)TTA>GTA	p.L160V		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	160	Helical; Name=4; (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						AAGCCACATAACATCCACTCC	0.557													C	18955854	C	C	18955854	3	2	33	1	0	0	0	0	1	0	0	0	9766	40	2	5	494	5	MRGPRX1	11	18955854	Missense_Mutation	SNP	A	TCGA-06-0169-01A-01D-1490-08	8375169	18955854	116050662	42	2033											
ATG2A	23130	broad.mit.edu	37	chr11	64663974	64663974	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttgctgagttccagggcgGcagaggctgtggatgagcca	18	8	0	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr11:64663974G>A	uc001obx.2	-	39	5502	c.5387C>T	c.(5386-5388)GCC>GTC	p.A1796V	ATG2A_uc001obw.2_Missense_Mutation_p.A561V	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1796							protein binding			ovary(1)|central_nervous_system(1)	2						TTCCAGGGCGGCAGAGGCTGT	0.637											OREG0004026	type=REGULATORY REGION|Gene=BC027481|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	A	64663974	A	A	64663974	3	1	33	1	0	0	0	0	1	0	0	0	1093	1203	42	3	441	3	ATG2A	11	64663974	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08	45708120	64663974	70342542	43	2034											
DSCAML1	57453	broad.mit.edu	37	chr11	117306485	117306485	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcacatcatccccttcaCcttgagcagacttgatgggt	7	13	4	3			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr11:117306485C>T	uc001prh.1	-	27	4933	c.4931G>A	c.(4930-4932)GGT>GAT	p.G1644D		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1584	Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		ATCCCCTTCACCTTGAGCAGA	0.522													T	117306485	T	T	117306485	3	4	33	1	0	0	0	0	1	0	0	0	4769	507	18	3	1438	3	DSCAML1	11	117306485	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	52642511	117306485	17700031	44	2035											
VPS11	55823	broad.mit.edu	37	chr11	118941054	118941054	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgtaactggattggcctttCgccaagcaggaaagaccact	10	11	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr11:118941054C>T	uc010ryx.1	+	5	625	c.583C>T	c.(583-585)CGC>TGC	p.R195C	VPS11_uc010ryy.1_Missense_Mutation_p.R41C	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	195					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		ATTGGCCTTTCGCCAAGCAGG	0.517													T	118941054	T	T	118941054	3	4	33	1	0	0	0	0	1	0	0	0	17185	884	31	2	596	2	VPS11	11	118941054	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	1634569	118941054	16065462	45	2036											
ROBO4	54538	broad.mit.edu	37	chr11	124765757	124765757	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcagcagtgtcacattttccAgctgaattcgcacagccaga	8	12	2	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr11:124765757A>C	uc001qbg.2	-	5	871	c.731T>G	c.(730-732)CTG>CGG	p.L244R	ROBO4_uc010sas.1_Missense_Mutation_p.L99R|ROBO4_uc001qbh.2_Missense_Mutation_p.L134R|ROBO4_uc001qbi.2_5'Flank|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	244					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CACATTTTCCAGCTGAATTCG	0.602													C	124765757	C	C	124765757	3	2	33	1	0	0	0	0	1	0	0	0	13516	188	7	5	2348	5	ROBO4	11	124765757	Missense_Mutation	SNP	A	TCGA-06-0169-01A-01D-1490-08	5824703	124765757	10240759	46	2037											
PTPN6	5777	broad.mit.edu	37	chr12	7069548	7069548	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagtacgggaacatcacctaTcccccagccatgaagaatgc	9	13	1	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr12:7069548T>C	uc001qsb.2	+	14	1865	c.1623T>C	c.(1621-1623)TAT>TAC	p.Y541Y	PTPN6_uc001qsa.1_Silent_p.Y543Y|PTPN6_uc010sfr.1_Silent_p.Y502Y|PTPN6_uc009zfl.1_Silent_p.Y541Y|PTPN6_uc010sfs.1_Silent_p.Y529Y	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	541					apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						ACATCACCTATCCCCCAGCCA	0.647													C	7069548	C	C	7069548	2	2	33	1	0	0	0	0	0	0	0	1	12792	1442	50	4		4	PTPN6	12	7069548	Silent	SNP	T	TCGA-06-0169-01A-01D-1490-08		7069548	126782347	47	2038											
ZC3H13	23091	broad.mit.edu	37	chr13	46559437	46559437	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtcaaaaaccttaccctttTcaggtaactcaggaaccctc	5	13	3	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr13:46559437T>C	uc010tfw.1	-	9	1721	c.1715A>G	c.(1714-1716)GAA>GGA	p.E572G	ZC3H13_uc001vas.1_Missense_Mutation_p.E572G|ZC3H13_uc001vat.1_Missense_Mutation_p.E572G	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	572	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CTTACCCTTTTCAGGTAACTC	0.358													C	46559437	C	C	46559437	3	2	33	1	0	0	0	0	1	0	0	0	17562	1783	62	4	3011	4	ZC3H13	13	46559437	Missense_Mutation	SNP	T	TCGA-06-0169-01A-01D-1490-08		46559437	68610441	48	2039											
OR4K13	390433	broad.mit.edu	37	chr14	20502502	20502502	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagtagcccagtgagcaccCgtgggctcatgatggtcatg	13	11	2	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr14:20502502C>T	uc010tkz.1	-	1	416	c.416G>A	c.(415-417)CGG>CAG	p.R139Q		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AGTGAGCACCCGTGGGCTCAT	0.488													T	20502502	T	T	20502502	3	4	33	1	0	0	0	0	1	0	0	0	11068	652	23	2	500	2	OR4K13	14	20502502	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08		20502502	86847038	49	2040											
NIPA2	81614	broad.mit.edu	37	chr15	23006662	23006662	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaatccaagccaggggatgCcgcagcacaggcttccctgc	12	14	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr15:23006662C>T	uc001yux.2	-	8	1255	c.642G>A	c.(640-642)CGG>CGA	p.R214R	NIPA2_uc001yuy.2_Silent_p.R214R|NIPA2_uc001yuz.2_Silent_p.R214R|NIPA2_uc001yva.2_Silent_p.R195R|NIPA2_uc001yvb.2_Silent_p.R214R|NIPA2_uc010ayb.2_Silent_p.R195R	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	214	Extracellular (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		CCAGGGGATGCCGCAGCACAG	0.502													T	23006662	T	T	23006662	2	4	33	1	0	0	0	0	0	0	0	1	10423	726	26	3		3	NIPA2	15	23006662	Silent	SNP	C	TCGA-06-0169-01A-01D-1490-08		23006662	79524730	50	2041											
MKRN3	7681	broad.mit.edu	37	chr15	23811322	23811322	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagatggccactgagggtggCgtttcgccgcctggggcctc	16	12	0	2	rs36072495	byFrequency	TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr15:23811322C>T	uc001ywh.3	+	1	869	c.393C>T	c.(391-393)GGC>GGT	p.G131G	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Silent_p.G131G	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	131						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CTGAGGGTGGCGTTTCGCCGC	0.622													T	23811322	T	T	23811322	2	4	33	1	0	0	0	0	0	0	0	1	9608	755	27	1		1	MKRN3	15	23811322	Silent	SNP	C	TCGA-06-0169-01A-01D-1490-08	804660	23811322	78720070	51	2042											
CLCN7	1186	broad.mit.edu	37	chr16	1507700	1507700	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgcactttgttacctttcCcacggccaggcccccgacca	8	17	0	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr16:1507700C>T	uc002clv.2	-	8	843	c.733G>A	c.(733-735)GGA>AGA	p.G245R	CLCN7_uc002clw.2_Missense_Mutation_p.G221R	NM_001287	NP_001278	P51798	CLCN7_HUMAN	chloride channel 7 isoform a	245	Selectivity filter part_2 (By similarity).					integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Hepatocellular(780;0.0893)				GTTACCTTTCCCACGGCCAGG	0.632													T	1507700	T	T	1507700	3	4	33	1	0	0	0	0	1	0	0	0	3468	632	22	3	1756	3	CLCN7	16	1507700	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08		1507700	88847053	52	2043											
PKD1	5310	broad.mit.edu	37	chr16	2147417	2147417	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgcctggccccgtgccagCtgccgcagattgctacccac	10	20	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr16:2147417C>T	uc002cos.1	-	33	10517	c.10308G>A	c.(10306-10308)CAG>CAA	p.Q3436Q	PKD1_uc002cot.1_Silent_p.Q3435Q|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3436	Cytoplasmic (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCCGTGCCAGCTGCCGCAGAT	0.677													T	2147417	T	T	2147417	2	4	33	1	0	0	0	0	0	0	0	1	11963	796	28	3		3	PKD1	16	2147417	Silent	SNP	C	TCGA-06-0169-01A-01D-1490-08	639717	2147417	88207336	53	2044											
GPR139	124274	broad.mit.edu	37	chr16	20043354	20043354	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccagcggttctggatgggCgccccatagaggtggtaaag	16	9	1	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr16:20043354C>T	uc002dgu.1	-	2	927	c.765G>A	c.(763-765)GCG>GCA	p.A255A	GPR139_uc010vaw.1_Silent_p.A162A	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	255	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)	2						TCTGGATGGGCGCCCCATAGA	0.532													T	20043354	T	T	20043354	2	4	33	1	0	0	0	0	0	0	0	1	6648	755	27	1		1	GPR139	16	20043354	Silent	SNP	C	TCGA-06-0169-01A-01D-1490-08	17895937	20043354	70311399	54	2045											
KRT13	3860	broad.mit.edu	37	chr17	39659672	39659672	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcggcctccacgctctggCgcagggccagctcattctca	11	16	3	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr17:39659672C>T	uc002hwu.1	-	3	665	c.602G>A	c.(601-603)CGC>CAC	p.R201H	KRT13_uc002hwv.1_Missense_Mutation_p.R201H|KRT13_uc002hww.2_Missense_Mutation_p.R94H|KRT13_uc010wfr.1_Missense_Mutation_p.R94H|KRT13_uc010cxo.2_Missense_Mutation_p.R201H|KRT13_uc002hwx.1_Missense_Mutation_p.R189H	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	201	Coil 1B.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				CACGCTCTGGCGCAGGGCCAG	0.478													T	39659672	T	T	39659672	3	4	33	1	0	0	0	0	1	0	0	0	8450	768	27	1	798	1	KRT13	17	39659672	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08		39659672	41535538	55	2046											
KRT14	3861	broad.mit.edu	37	chr17	39741254	39741254	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaagtcatccgcggccagaCgggcattgtcaatctgcaga	13	11	3	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr17:39741254C>T	uc002hxf.1	-	2	642	c.581G>A	c.(580-582)CGT>CAT	p.R194H	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Missense_Mutation_p.R194H	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	194	Coil 1B.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				CGCGGCCAGACGGGCATTGTC	0.502													T	39741254	T	T	39741254	3	4	33	1	0	0	0	0	1	0	0	0	8451	536	19	1	865	1	KRT14	17	39741254	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	81582	39741254	41453956	56	2047											
MED13	9969	broad.mit.edu	37	chr17	60060308	60060308	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccagctccacgaggagtcCgaggagtccttggagtcctt	12	13	0	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr17:60060308C>T	uc002izo.2	-	16	3133	c.3056G>A	c.(3055-3057)CGG>CAG	p.R1019Q		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1019					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						ACGAGGAGTCCGAGGAGTCCT	0.512													T	60060308	T	T	60060308	3	4	33	1	0	0	0	0	1	0	0	0	9430	652	23	2	3528	2	MED13	17	60060308	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	20319054	60060308	21134902	57	2048											
TMEM146	257062	broad.mit.edu	37	chr19	5778542	5778542	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagctgctacgcacagcacGcggccgcaggatcaagaagt	12	13	1	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr19:5778542G>A	uc002mda.2	+	22	2313	c.2252G>A	c.(2251-2253)CGC>CAC	p.R751H		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	751	Cytoplasmic (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CGCACAGCACGCGGCCGCAGG	0.612													A	5778542	A	A	5778542	3	1	33	1	0	0	0	0	1	0	0	0	16057	1087	38	1	2338	1	TMEM146	19	5778542	Missense_Mutation	SNP	G	TCGA-06-0169-01A-01D-1490-08		5778542	53350441	58	2049											
MUC16	94025	broad.mit.edu	37	chr19	9067788	9067788	+	Frame_Shift_Del	DEL	G	-	-													ccacagatgccagcatatctGtggtcttcactaggccagag							TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr19:9067788delG	uc002mkp.2	-	3	19862	c.19658delC	c.(19657-19659)ACAfs	p.T6553fs		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6555	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGCATATCTGTGGTCTTCAC	0.473													-	9067788	-	-	9067788	7	5	33	1	0	1	0	1	0	0	0	0	9973	1377	48	0	24193	0	MUC16	19	9067788	Frame_Shift_Del	DEL	G	TCGA-06-0169-01A-01D-1490-08	3289246	9067788	50061195	59	2050											
PAPL	390928	broad.mit.edu	37	chr19	39591660	39591660	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcccatgtactgctccaaCgcagatctggacgactgcac	10	15	1	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr19:39591660C>T	uc002oki.2	+	8	1153	c.879C>T	c.(877-879)AAC>AAT	p.N293N	PAPL_uc010egl.2_Missense_Mutation_p.T252M	NM_001004318	NP_001004318	Q6ZNF0	PAPL_HUMAN	iron/zinc purple acid phosphatase-like protein	293						extracellular region	acid phosphatase activity|metal ion binding				0						ACTGCTCCAACGCAGATCTGG	0.612													T	39591660	T	T	39591660	2	4	33	1	0	0	0	0	0	0	0	1	11427	535	19	1		1	PAPL	19	39591660	Silent	SNP	C	TCGA-06-0169-01A-01D-1490-08	30523872	39591660	19537323	60	2051											
KDELR1	10945	broad.mit.edu	37	chr19	48887570	48887570	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcgatgaggtcgaagaagCcctcgaaatggtagcgccag	15	9	0	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr19:48887570C>T	uc002pjb.1	-	4	716	c.521G>A	c.(520-522)GGC>GAC	p.G174D	KDELR1_uc002pja.1_Missense_Mutation_p.G112D	NM_006801	NP_006792	P24390	ERD21_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum	174	Lumenal (Potential).				intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane|membrane fraction	KDEL sequence binding|protein binding|receptor activity				0		all_epithelial(76;2.48e-06)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Prostate(7;0.122)|Breast(70;0.203)		all cancers(93;0.000114)|OV - Ovarian serous cystadenocarcinoma(262;0.000136)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.0145)		GTCGAAGAAGCCCTCGAAATG	0.542													T	48887570	T	T	48887570	3	4	33	1	0	0	0	0	1	0	0	0	8119	739	26	3	125	3	KDELR1	19	48887570	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08	9295910	48887570	10241413	61	2052											
TRPM4	54795	broad.mit.edu	37	chr19	49705399	49705400	+	Splice_Site	INS	-	T	T													tgctcattgccatgttcaggINStgaggcctgactgctctctg							TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr19:49705399_49705400insT	uc002pmw.2	+	20	3203	c.3131_splice	c.e20+1	p.S1044_splice	TRPM4_uc010emu.2_Splice_Site_p.S899_splice|TRPM4_uc010yak.1_Splice_Site_p.S508_splice|TRPM4_uc002pmx.2_Splice_Site_p.S870_splice|TRPM4_uc010emv.2_Splice_Site_p.S929_splice|TRPM4_uc010yal.1_Splice_Site_p.S690_splice|TRPM4_uc002pmy.2_Splice_Site_p.S386_splice	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,						dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CCATGTTCAGGTGAGGCCTGAC	0.55													T	49705400	T	T	49705399	8	5	33	1	0	1	1	0	0	0	1	0	16585	1275	44	0	3210	0	TRPM4	19	49705399	Splice_Site	INS	-	TCGA-06-0169-01A-01D-1490-08	817829	49705399	9423584	62	2053											
SLC24A3	57419	broad.mit.edu	37	chr20	19677519	19677519	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctgctgggaccagcgtgCctgactgcatggccagcctc	14	14	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr20:19677519C>T	uc002wrl.2	+	14	1767	c.1570C>T	c.(1570-1572)CCT>TCT	p.P524S		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	524	Alpha-2.|Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						GACCAGCGTGCCTGACTGCAT	0.448													T	19677519	T	T	19677519	3	4	33	1	0	0	0	0	1	0	0	0	14467	739	26	3	1624	3	SLC24A3	20	19677519	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08		19677519	43348001	63	2054											
ZSWIM1	90204	broad.mit.edu	37	chr20	44512381	44512381	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agccccctgccagctgcagcTgctactttaaccaggccttc	8	17	0	0			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr20:44512381T>C	uc010ghi.2	+	2	1263	c.1150T>C	c.(1150-1152)TGC>CGC	p.C384R	ZSWIM1_uc010zxh.1_Missense_Mutation_p.C257R	NM_080603	NP_542170	Q9BR11	ZSWM1_HUMAN	zinc finger, SWIM-type containing 1	384	SWIM-type.						zinc ion binding			skin(1)	1		Myeloproliferative disorder(115;0.028)				CAGCTGCAGCTGCTACTTTAA	0.597													C	44512381	C	C	44512381	3	2	33	1	0	0	0	0	1	0	0	0	18237	1580	55	4	1152	4	ZSWIM1	20	44512381	Missense_Mutation	SNP	T	TCGA-06-0169-01A-01D-1490-08	24834862	44512381	18513139	64	2055											
COL20A1	57642	broad.mit.edu	37	chr20	61938888	61938888	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cccgtgcctgctgacatggtCttcctggtggacgggtcctg	14	13	1	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr20:61938888C>G	uc011aau.1	+	6	643	c.543C>G	c.(541-543)GTC>GTG	p.V181V	COL20A1_uc011aav.1_Silent_p.V2V	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	181	VWFA.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					CTGACATGGTCTTCCTGGTGG	0.652													G	61938888	G	G	61938888	2	3	33	1	0	0	0	0	0	0	0	1	3679	900	32	5		5	COL20A1	20	61938888	Silent	SNP	C	TCGA-06-0169-01A-01D-1490-08	17426507	61938888	1086632	65	2056											
TMPRSS2	7113	broad.mit.edu	37	chr21	42842599	42842599	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctcggtggccccccaccCggaaatccagcagagctgtt	10	17	0	1			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr21:42842599C>T	uc002yzj.2	-	11	1281	c.1147G>A	c.(1147-1149)GGG>AGG	p.G383R	TMPRSS2_uc010gor.2_Missense_Mutation_p.G420R|TMPRSS2_uc010gos.1_Missense_Mutation_p.G383R	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	383	Peptidase S1.|Extracellular (Potential).				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				GCCCCCCACCCGGAAATCCAG	0.488			T	ERG|ETV1|ETV4|ETV5	prostate 								T	42842599	T	T	42842599	3	4	33	1	0	0	0	0	1	0	0	0	16244	652	23	2	347	2	TMPRSS2	21	42842599	Missense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08		42842599	5287296	66	2057											
FBXO7	25793	broad.mit.edu	37	chr22	32887162	32887162	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcctcttctggcttttaccCgacaaggtaagagatgaaat	8	9	2	2			TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chr22:32887162C>T	uc003amq.2	+	6	1244	c.961C>T	c.(961-963)CGA>TGA	p.R321*	FBXO7_uc003amp.1_3'UTR|FBXO7_uc003amr.2_Nonsense_Mutation_p.R207*|FBXO7_uc003ams.2_Nonsense_Mutation_p.R165*|FBXO7_uc003amt.2_Nonsense_Mutation_p.R242*|FBXO7_uc003amu.2_Nonsense_Mutation_p.R207*|FBXO7_uc003amv.2_5'Flank	NM_012179	NP_036311	Q9Y3I1	FBX7_HUMAN	F-box only protein 7 isoform 1	321					cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						GGCTTTTACCCGACAAGGTAA	0.368													T	32887162	T	T	32887162	4	4	33	1	0	0	0	0	0	1	0	0	5760	644	23	2	1024	2	FBXO7	22	32887162	Nonsense_Mutation	SNP	C	TCGA-06-0169-01A-01D-1490-08		32887162	18417404	67	2058											
EIF2S3	1968	broad.mit.edu	37	chrX	24094874	24094877	+	Frame_Shift_Del	DEL	CAAT	-	-													tcagataagaagaggagtgaCaatcaagccaacagtagatg							TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chrX:24094874_24094877delCAAT	uc004dbc.2	+	12	1412_1415	c.1391_1394delCAAT	c.(1390-1395)ACAATCfs	p.T464fs		NM_001415	NP_001406	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2,	464_465						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			lung(1)	1						AGAGGAGTGACAATCAAGCCAACA	0.348													-	24094877	-	-	24094874	7	5	33	1	0	1	0	1	0	0	0	0	5011	478	17	0	1437	0	EIF2S3	23	24094874	Frame_Shift_Del	DEL	CAAT	TCGA-06-0169-01A-01D-1490-08		24094874	131175686	68	2059											
NAP1L2	4674	broad.mit.edu	37	chrX	72433664	72433666	+	In_Frame_Del	DEL	TCC	-	-													ctccagtagcctcaatgtcgTcctcctcctcctcctcctcc							TCGA-06-0169-01A-01D-1490-08	TCGA-06-0169-10A-01D-1490-08									Somatic	Phase_I	Capture				Illumina GAIIx	06053a14-2d9a-4df0-a79b-81bda36bf3c3	461cc736-47e8-46bc-90ca-7f5f8f1411a2	g.chrX:72433664_72433666delTCC	uc004ebi.2	-	1	1019_1021	c.663_665delGGA	c.(661-666)GAGGAC>GAC	p.E221del	NAP1L2_uc011mqj.1_In_Frame_Del_p.E79del	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	221	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					CTCAATGTCGtcctcctcctcct	0.33													-	72433666	-	-	72433664	7	5	33	1	0	1	0	1	0	0	0	0	10157	1667	58	0	721	0	NAP1L2	23	72433664	In_Frame_Del	DEL	TCC	TCGA-06-0169-01A-01D-1490-08	48338790	72433664	82836896	69	2060											
TMCO4	255104	broad.mit.edu	37	chr1	20107156	20107156	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggttggcctcagtcagctcCcggcccgtgggcaggtgtgg	17	13	2	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr1:20107156C>T	uc001bcn.2	-	4	338	c.96G>A	c.(94-96)CGG>CGA	p.R32R	TMCO4_uc001bcm.2_Silent_p.R32R|TMCO4_uc001bco.1_Silent_p.R32R|TMCO4_uc001bcp.1_Silent_p.R32R|TMCO4_uc009vpn.1_Silent_p.R32R|TMCO4_uc001bcq.1_Silent_p.R32R	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	32						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		CAGTCAGCTCCCGGCCCGTGG	0.612													T	20107156	T	T	20107156	2	4	34	1	0	0	0	0	0	0	0	1	15995	610	22	3		3	TMCO4	1	20107156	Silent	SNP	C	TCGA-06-0173-01A-01D-1491-08		20107156	229143465	1	2061											
ARID1A	8289	broad.mit.edu	37	chr1	27101098	27101098	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatttccattccagtttggCcgagaccgtgtctctgcacc	8	14	1	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr1:27101098C>T	uc001bmv.1	+	18	4753	c.4380C>T	c.(4378-4380)GGC>GGT	p.G1460G	ARID1A_uc001bmt.1_Silent_p.G1459G|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Silent_p.G1077G|ARID1A_uc001bmx.1_Silent_p.G306G|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1460					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TCCAGTTTGGCCGAGACCGTG	0.582			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								T	27101098	T	T	27101098	2	4	34	1	0	0	0	0	0	0	0	1	913	726	26	3		3	ARID1A	1	27101098	Silent	SNP	C	TCGA-06-0173-01A-01D-1491-08	6993942	27101098	222149523	2	2062											
GNL2	29889	broad.mit.edu	37	chr1	38049466	38049466	+	Splice_Site	DEL	A	-	-													ggagagaatttaggagtcttAccttgtagagctcaccccat							TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr1:38049466delA	uc001cbk.2	-	6	799	c.636_splice	c.e6+1	p.K212_splice	GNL2_uc010oif.1_Splice_Site_p.K53_splice|GNL2_uc009vve.2_3'UTR	NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2						ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				TAGGAGTCTTACCTTGTAGAG	0.383													-	38049466	-	-	38049466	8	5	34	1	0	1	0	1	0	0	1	0	6536	405	14	0	1601	0	GNL2	1	38049466	Splice_Site	DEL	A	TCGA-06-0173-01A-01D-1491-08	10948368	38049466	211201155	3	2063											
ISG20L2	81875	broad.mit.edu	37	chr1	156697400	156697400	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttccttctaatgcctttttGggaggaggttccccaaaatc	8	10	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr1:156697400G>C	uc001fps.1	-	1	306	c.45C>G	c.(43-45)CCC>CCG	p.P15P	ISG20L2_uc001fpt.1_Silent_p.P15P|C1orf66_uc001fpu.2_5'Flank|C1orf66_uc001fpv.2_5'Flank	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene	15					ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATGCCTTTTTGGGAGGAGGTT	0.458													C	156697400	C	C	156697400	2	2	34	1	0	0	0	0	0	0	0	1	7855	1335	47	5		5	ISG20L2	1	156697400	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	118647934	156697400	92553221	4	2064											
NFASC	23114	broad.mit.edu	37	chr1	204943900	204943900	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggcatctacacctgtgtcGccaccaacatcctgggcaaa	9	14	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr1:204943900G>A	uc001hbj.2	+	14	1835	c.1507G>A	c.(1507-1509)GCC>ACC	p.A503T	NFASC_uc001hbh.2_Missense_Mutation_p.A503T|NFASC_uc010pqz.1_Missense_Mutation_p.A497T|NFASC_uc010pra.1_Missense_Mutation_p.A514T|NFASC_uc001hbi.2_Missense_Mutation_p.A514T|NFASC_uc010prb.1_Missense_Mutation_p.A514T|NFASC_uc010prc.1_Missense_Mutation_p.A70T|NFASC_uc001hbk.1_Missense_Mutation_p.A324T	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	503	Extracellular (Potential).|Ig-like C2-type 5.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CACCTGTGTCGCCACCAACAT	0.532													A	204943900	A	A	204943900	3	1	34	1	0	0	0	0	1	0	0	0	10359	1087	38	1	1608	1	NFASC	1	204943900	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	48246500	204943900	44306721	5	2065											
OBSCN	84033	broad.mit.edu	37	chr1	228520994	228520994	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccaggtggcccctggcacaCgcctggccaagttccagctc	11	17	0	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr1:228520994C>T	uc009xez.1	+	58	15870	c.15826C>T	c.(15826-15828)CGC>TGC	p.R5276C	OBSCN_uc001hsn.2_Missense_Mutation_p.R5276C|OBSCN_uc001hsr.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5276	Ig-like 50.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCCTGGCACACGCCTGGCCAA	0.637													T	228520994	T	T	228520994	3	4	34	1	0	0	0	0	1	0	0	0	10812	536	19	1	16052	1	OBSCN	1	228520994	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	23577094	228520994	20729627	6	2066											
OR2W5	441932	broad.mit.edu	37	chr1	247654765	247654765	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgctgggctccaccgagtgCgtcctcctggttgtcatgtc	12	13	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr1:247654765C>T	uc001icz.1	+	1	336	c.336C>T	c.(334-336)TGC>TGT	p.C112C		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCACCGAGTGCGTCCTCCTGG	0.602													T	247654765	T	T	247654765	2	4	34	1	0	0	0	0	0	0	0	1	11034	776	27	1		1	OR2W5	1	247654765	Silent	SNP	C	TCGA-06-0173-01A-01D-1491-08	19133771	247654765	1595856	7	2067											
APOB	338	broad.mit.edu	37	chr2	21235218	21235218	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gagccggccagtgttaggatCcctctgacaagacaggccat	12	12	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr2:21235218C>T	uc002red.2	-	26	4650	c.4522G>A	c.(4522-4524)GAT>AAT	p.D1508N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1508					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTGTTAGGATCCCTCTGACAA	0.458													T	21235218	T	T	21235218	3	4	34	1	0	0	0	0	1	0	0	0	785	855	30	3	9185	3	APOB	2	21235218	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08		21235218	221964155	8	2068											
GPR113	165082	broad.mit.edu	37	chr2	26533656	26533656	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccccaggtgaggccaaagatGggtgtaagaatgagcagggc	16	8	0	4			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr2:26533656G>T	uc002rhe.3	-	11	2940	c.2940C>A	c.(2938-2940)CCC>CCA	p.P980P	GPR113_uc010yky.1_Silent_p.P911P|GPR113_uc002rhb.1_Silent_p.P583P|GPR113_uc010eyk.1_Silent_p.P781P|GPR113_uc002rhc.1_Silent_p.P583P|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	980	Helical; Name=6; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCAAAGATGGGTGTAAGAA	0.572													T	26533656	T	T	26533656	2	4	34	1	0	0	0	0	0	0	0	1	6630	1335	47	5		5	GPR113	2	26533656	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	5298438	26533656	216665717	9	2069											
NBEAL1	65065	broad.mit.edu	37	chr2	204002914	204002914	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaagatgttagaatgggcaaTctcagaaaacagagaagcaa	10	5	1	4			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr2:204002914T>C	uc002uzt.3	+	29	4841	c.4508T>C	c.(4507-4509)ATC>ACC	p.I1503T	NBEAL1_uc002uzs.3_Missense_Mutation_p.I213T	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1503							binding			ovary(1)|skin(1)	2						GAATGGGCAATCTCAGAAAAC	0.373													C	204002914	C	C	204002914	3	2	34	1	0	0	0	0	1	0	0	0	10188	1435	50	4	4618	4	NBEAL1	2	204002914	Missense_Mutation	SNP	T	TCGA-06-0173-01A-01D-1491-08	177469258	204002914	39196459	10	2070											
MARCH4	57574	broad.mit.edu	37	chr2	217234886	217234886	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttgaggagaccctggtggCgcaacatctggggggctggg	18	9	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr2:217234886C>T	uc002vgb.2	-	1	1865	c.98G>A	c.(97-99)CGC>CAC	p.R33H		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	33						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		ACCCTGGTGGCGCAACATCTG	0.632													T	217234886	T	T	217234886	3	4	34	1	0	0	0	0	1	0	0	0	9303	768	27	1	1150	1	MARCH4	2	217234886	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	13231972	217234886	25964487	11	2071											
SPP2	6694	broad.mit.edu	37	chr2	234959451	234959451	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atgatttccagaatggagaaGatgacgatgatgatgaagat	12	3	0	9			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr2:234959451G>A	uc002vvk.1	+	1	106	c.21G>A	c.(19-21)AAG>AAA	p.K7K	SPP2_uc010fyl.1_5'UTR	NM_006944	NP_008875	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa precursor	7					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity				0		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		GAATGGAGAAGATGACGATGA	0.423													A	234959451	A	A	234959451	2	1	34	1	0	0	0	0	0	0	0	1	15086	933	33	3		3	SPP2	2	234959451	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	17724565	234959451	8239922	12	2072											
TTLL3	26140	broad.mit.edu	37	chr3	9839460	9839463	+	Splice_Site	DEL	AGGT	-	-													acaagccggaagtggaagtcAggtagggaaggacaagtcaa							TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr3:9839460_9839463delAGGT	uc003btd.3	+	1	119	c.-160_splice	c.e1+1		ARPC4_uc003bsz.1_Splice_Site_p.R41_splice|ARPC4_uc003bta.1_Splice_Site|ARPC4_uc003btb.1_Splice_Site|ARPC4_uc003btc.1_Splice_Site			Q9Y4R7	TTLL3_HUMAN	RecName: Full=Tubulin--tyrosine ligase-like protein 3; AltName: Full=HOTTL;						axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					AGTGGAAGTCAGGTAGGGAAGGAC	0.564													-	9839463	-	-	9839460	8	5	34	1	0	1	0	1	0	0	1	0	16725	202	7	0		0	TTLL3	3	9839460	Splice_Site	DEL	AGGT	TCGA-06-0173-01A-01D-1491-08		9839460	188182970	13	2073											
GUCA1C	9626	broad.mit.edu	37	chr3	108627021	108627021	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caggagatcctgatcttttgCcatgccattgataaattctt	7	9	2	3			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr3:108627021C>A	uc003dxj.2	-	4	546	c.478G>T	c.(478-480)GCA>TCA	p.A160S	GUCA1C_uc003dxk.2_Missense_Mutation_p.G173V	NM_005459	NP_005450	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	160	EF-hand 4.				signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0						TGATCTTTTGCCATGCCATTG	0.398													A	108627021	A	A	108627021	3	1	34	1	0	0	0	0	1	0	0	0	6890	739	26	5	155	5	GUCA1C	3	108627021	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	98787561	108627021	89395409	14	2074											
ABHD10	55347	broad.mit.edu	37	chr3	111697949	111697949	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctgtggcggcctgggtacCttgtcggagctggggctggg	20	9	0	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr3:111697949C>T	uc003dyk.3	+	1	122	c.41C>T	c.(40-42)CCT>CTT	p.P14L	ABHD10_uc011bhq.1_5'UTR	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	14						mitochondrion	serine-type peptidase activity				0						GCCTGGGTACCTTGTCGGAGC	0.682													T	111697949	T	T	111697949	3	4	34	1	0	0	0	0	1	0	0	0	74	681	24	3	43	3	ABHD10	3	111697949	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	3070928	111697949	86324481	15	2075											
AFAP1	60312	broad.mit.edu	37	chr4	7802222	7802222	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccggaacgtcagaggatGtttagaatccaaacccggga	12	10	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr4:7802222G>A	uc003gkg.1	-	10	1486	c.1213C>T	c.(1213-1215)CAT>TAT	p.H405Y	AFAP1_uc011bwk.1_Missense_Mutation_p.H405Y	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	405	PH 2.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						GTCAGAGGATGTTTAGAATCC	0.547													A	7802222	A	A	7802222	3	1	34	1	0	0	0	0	1	0	0	0	353	1377	48	3	1267	3	AFAP1	4	7802222	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08		7802222	183352054	16	2076											
C4orf21	55345	broad.mit.edu	37	chr4	113510967	113510968	+	Frame_Shift_Del	DEL	TT	-	-													taccatgaagtcttcatctcTtgagttcaaagaaaaggtag							TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr4:113510967_113510968delTT	uc003iau.2	-	11	3250_3251	c.3039_3040delAA	c.(3037-3042)TCAAGAfs	p.S1013fs	C4orf21_uc003iav.2_5'Flank|C4orf21_uc003iaw.2_Frame_Shift_Del_p.S1013fs	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TCTTCATCTCTTGAGTTCAAAG	0.391													-	113510968	-	-	113510967	7	5	34	1	0	1	0	1	0	0	0	0	2254	1617	56	0	3346	0	C4orf21	4	113510967	Frame_Shift_Del	DEL	TT	TCGA-06-0173-01A-01D-1491-08	105708745	113510967	77643309	17	2077											
LRAT	9227	broad.mit.edu	37	chr4	155670163	155670163	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agactgtgaagataattattCgtgatcagagaagtgttctt	10	4	2	5			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr4:155670163C>T	uc003iom.1	+	2	895	c.568C>T	c.(568-570)CGT>TGT	p.R190C	LRAT_uc003ion.1_Missense_Mutation_p.R190C	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	190	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	GATAATTATTCGTGATCAGAG	0.373													T	155670163	T	T	155670163	3	4	34	1	0	0	0	0	1	0	0	0	8930	884	31	2	574	2	LRAT	4	155670163	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	42159196	155670163	35484113	18	2078											
ANP32C	23520	broad.mit.edu	37	chr4	165118645	165118645	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gccaatacttccaggcccccTgagactcttagttcaagctt	7	14	2	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr4:165118645T>A	uc011cjk.1	-	1	219	c.219A>T	c.(217-219)TCA>TCT	p.S73S	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	73	LRR 2.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		CCAGGCCCCCTGAGACTCTTA	0.403													A	165118645	A	A	165118645	2	1	34	1	0	0	0	0	0	0	0	1	707	1567	55	5		5	ANP32C	4	165118645	Silent	SNP	T	TCGA-06-0173-01A-01D-1491-08	9448482	165118645	26035631	19	2079											
TRIML1	339976	broad.mit.edu	37	chr4	189068289	189068289	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggagatgattacagcctctgGgtctcgtcacctttgaaagg	12	9	3	3			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr4:189068289G>T	uc003izm.1	+	6	1285	c.1170G>T	c.(1168-1170)TGG>TGT	p.W390C	TRIML1_uc003izn.1_Missense_Mutation_p.W114C	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	390	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		ACAGCCTCTGGGTCTCGTCAC	0.488													T	189068289	T	T	189068289	3	4	34	1	0	0	0	0	1	0	0	0	16547	1241	43	5	1192	5	TRIML1	4	189068289	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	23949644	189068289	2085987	20	2080											
CDH9	1007	broad.mit.edu	37	chr5	26902711	26902711	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acacaggaggctcatctataTcttccacagatattttgacc	6	11	3	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr5:26902711T>A	uc003jgs.1	-	7	1296	c.1127A>T	c.(1126-1128)GAT>GTT	p.D376V		NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	376	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CTCATCTATATCTTCCACAGA	0.408													A	26902711	A	A	26902711	3	1	34	1	0	0	0	0	1	0	0	0	3117	1435	50	5	1266	5	CDH9	5	26902711	Missense_Mutation	SNP	T	TCGA-06-0173-01A-01D-1491-08		26902711	154012549	21	2081											
LHFPL2	10184	broad.mit.edu	37	chr5	77805969	77805969	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatgaaggcaatgagctcgGcaaaagccaccacaatactc	8	12	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr5:77805969G>A	uc003kfo.2	-	4	744	c.68C>T	c.(67-69)GCC>GTC	p.A23V		NM_005779	NP_005770	Q6ZUX7	LHPL2_HUMAN	lipoma HMGIC fusion partner-like 2	23	Helical; (Potential).					integral to membrane					0		all_lung(232;0.000409)|Lung NSC(167;0.00108)|Ovarian(174;0.0107)|Prostate(461;0.218)		OV - Ovarian serous cystadenocarcinoma(54;6.48e-46)|Epithelial(54;8.43e-42)|all cancers(79;1.42e-36)		AATGAGCTCGGCAAAAGCCAC	0.438													A	77805969	A	A	77805969	3	1	34	1	0	0	0	0	1	0	0	0	8765	1203	42	3	626	3	LHFPL2	5	77805969	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	50903258	77805969	103109291	22	2082											
CCDC112	153733	broad.mit.edu	37	chr5	114607281	114607281	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcctttaacttgaaaatttCctcccttttttgctgctttt	3	10	0	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr5:114607281C>T	uc003kqy.2	-	7	1225	c.712G>A	c.(712-714)GAA>AAA	p.E238K	CCDC112_uc003kqz.2_Missense_Mutation_p.E321K|CCDC112_uc003kra.2_Missense_Mutation_p.E321K	NM_152549	NP_689762	Q8NEF3	CC112_HUMAN	coiled-coil domain containing 112 isoform 2	238	Potential.										0		all_cancers(142;0.000523)|all_epithelial(76;6.44e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;4.09e-08)|Epithelial(69;5.28e-08)|all cancers(49;7.06e-06)		TTGAAAATTTCCTCCCTTTTT	0.219													T	114607281	T	T	114607281	3	4	34	1	0	0	0	0	1	0	0	0	2749	864	30	3	644	3	CCDC112	5	114607281	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	36801312	114607281	66307979	23	2083											
ODZ2	57451	broad.mit.edu	37	chr5	167674863	167674863	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accgctatgatggcgtaggaCggcgggcttcctacaagacc	13	12	0	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr5:167674863C>T	uc010jjd.2	+	27	6892	c.6892C>T	c.(6892-6894)CGG>TGG	p.R2298W	ODZ2_uc003lzr.3_Missense_Mutation_p.R2068W|ODZ2_uc003lzt.3_Missense_Mutation_p.R1671W|ODZ2_uc010jje.2_Missense_Mutation_p.R1562W	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TGGCGTAGGACGGCGGGCTTC	0.552													T	167674863	T	T	167674863	3	4	34	1	0	0	0	0	1	0	0	0	10835	527	19	1	6998	1	ODZ2	5	167674863	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	53067582	167674863	13240397	24	2084											
OR10C1	442194	broad.mit.edu	37	chr6	29408233	29408233	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacagctagctgggtcggcGtgggcctgtggggtgctggt	19	9	0	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr6:29408233G>A	uc011dlp.1	+	1	441	c.441G>A	c.(439-441)GCG>GCA	p.A147A	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGGGTCGGCGTGGGCCTGTG	0.622													A	29408233	A	A	29408233	2	1	34	1	0	0	0	0	0	0	0	1	10898	1132	40	1		1	OR10C1	6	29408233	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08		29408233	141706834	25	2085											
GRM4	2914	broad.mit.edu	37	chr6	34101001	34101001	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttaggcagcaggtccgggtcGttgttgatgcgatccagggc	16	9	0	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr6:34101001G>A	uc003oir.3	-	1	443	c.273C>T	c.(271-273)AAC>AAT	p.N91N	GRM4_uc011dsn.1_Silent_p.N91N|GRM4_uc010jvh.2_Silent_p.N91N|GRM4_uc010jvi.2_Translation_Start_Site|GRM4_uc010jvk.1_Silent_p.N10N	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	91	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	GGTCCGGGTCGTTGTTGATGC	0.622													A	34101001	A	A	34101001	2	1	34	1	0	0	0	0	0	0	0	1	6799	1136	40	1		1	GRM4	6	34101001	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	4692768	34101001	137014066	26	2086											
DNAH8	1769	broad.mit.edu	37	chr6	38704936	38704936	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttctaccagctgttcttgcaAcaaacaactggggtgcttta	8	10	2	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr6:38704936A>G	uc003ooe.1	+	4	805	c.205A>G	c.(205-207)ACA>GCA	p.T69A		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGTTCTTGCAACAAACAACTG	0.383													G	38704936	G	G	38704936	3	3	34	1	0	0	0	0	1	0	0	0	4607	43	2	4	211	4	DNAH8	6	38704936	Missense_Mutation	SNP	A	TCGA-06-0173-01A-01D-1491-08	4603935	38704936	132410131	27	2087											
AIM1	202	broad.mit.edu	37	chr6	106967934	106967934	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgggaagtgagtgtccaTccagagtcctcgtccaggtc	13	11	0	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr6:106967934T>C	uc003prh.2	+	2	2114	c.1627T>C	c.(1627-1629)TCC>CCC	p.S543P		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	543							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TGAGTGTCCATCCAGAGTCCT	0.527													C	106967934	C	C	106967934	3	2	34	1	0	0	0	0	1	0	0	0	430	1435	50	4	1633	4	AIM1	6	106967934	Missense_Mutation	SNP	T	TCGA-06-0173-01A-01D-1491-08	68262998	106967934	64147133	28	2088											
C6orf170	221322	broad.mit.edu	37	chr6	121642861	121642861	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accctgattccgatcagatgTgcatttttccatttcttctt	5	11	3	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr6:121642861T>C	uc003pyo.1	-	2	303	c.235A>G	c.(235-237)ACA>GCA	p.T79A	C6orf170_uc003pyq.1_RNA	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	79					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		CGATCAGATGTGCATTTTTCC	0.368													C	121642861	C	C	121642861	3	2	34	1	0	0	0	0	1	0	0	0	2344	1696	59	4	3662	4	C6orf170	6	121642861	Missense_Mutation	SNP	T	TCGA-06-0173-01A-01D-1491-08	14674927	121642861	49472206	29	2089											
FNDC1	84624	broad.mit.edu	37	chr6	159653416	159653416	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctctcctgcccaccacgcGtccacccagggcacctctca	7	22	2	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr6:159653416G>A	uc010kjv.2	+	11	2072	c.1872G>A	c.(1870-1872)GCG>GCA	p.A624A	FNDC1_uc010kjw.1_Silent_p.A509A	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	624						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CCCACCACGCGTCCACCCAGG	0.667													A	159653416	A	A	159653416	2	1	34	1	0	0	0	0	0	0	0	1	5968	1132	40	1		1	FNDC1	6	159653416	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	38010555	159653416	11461651	30	2090											
SLC22A2	6582	broad.mit.edu	37	chr6	160679423	160679423	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgtacacccagccgtcccGgcaggggcccagtggcaggc	14	17	0	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr6:160679423G>A	uc003qtf.2	-	1	537	c.367C>T	c.(367-369)CGG>TGG	p.R123W	SLC22A2_uc003qte.1_Missense_Mutation_p.R123W|SLC22A2_uc003qth.1_Missense_Mutation_p.R123W	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	123	Extracellular (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CAGCCGTCCCGGCAGGGGCCC	0.627													A	160679423	A	A	160679423	3	1	34	1	0	0	0	0	1	0	0	0	14450	1115	39	2	1344	2	SLC22A2	6	160679423	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	1026007	160679423	10435644	31	2091											
HECW1	23072	broad.mit.edu	37	chr7	43519279	43519279	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatccctcttcagaacggtcGtcttcccaatcatctaactc	4	15	5	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr7:43519279G>A	uc003tid.1	+	17	3775	c.3170G>A	c.(3169-3171)CGT>CAT	p.R1057H	HECW1_uc011kbi.1_Missense_Mutation_p.R1023H	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1057					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CAGAACGGTCGTCTTCCCAAT	0.542													A	43519279	A	A	43519279	3	1	34	1	0	0	0	0	1	0	0	0	7042	1145	40	1	3228	1	HECW1	7	43519279	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08		43519279	115619384	32	2092											
BAZ1B	9031	broad.mit.edu	37	chr7	72892641	72892641	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aggtgggccttttttaggaaTgtgaaagttagtgtgcagct	14	4	0	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr7:72892641T>A	uc003tyc.2	-	7	1495	c.1150A>T	c.(1150-1152)ATT>TTT	p.I384F		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	384	Lys-rich.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTTTTAGGAATGTGAAAGTTA	0.433													A	72892641	A	A	72892641	3	1	34	1	0	0	0	0	1	0	0	0	1330	1464	51	5	3353	5	BAZ1B	7	72892641	Missense_Mutation	SNP	T	TCGA-06-0173-01A-01D-1491-08	29373362	72892641	86246022	33	2093											
PIK3CG	5294	broad.mit.edu	37	chr7	106524646	106524646	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttattcctgtgcaggctactGtgtggcaacctttgttcttg	10	9	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr7:106524646G>C	uc003vdv.3	+	9	2892	c.2807G>C	c.(2806-2808)TGT>TCT	p.C936S	PIK3CG_uc003vdu.2_Missense_Mutation_p.C936S|PIK3CG_uc003vdw.2_Missense_Mutation_p.C936S	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	936	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding	p.C936S(1)		lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GCAGGCTACTGTGTGGCAACC	0.358													C	106524646	C	C	106524646	3	2	34	1	0	0	0	0	1	0	0	0	11916	1377	48	5	2837	5	PIK3CG	7	106524646	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	33632005	106524646	52614017	34	2094											
IMPDH1	3614	broad.mit.edu	37	chr7	128038490	128038490	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agactatgacgtcgacgcccGcctgggtgagcaggtccaga	14	12	0	4			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr7:128038490G>A	uc011kol.1	-	7	903	c.797C>T	c.(796-798)GCG>GTG	p.A266V	IMPDH1_uc011kom.1_Missense_Mutation_p.A261V|IMPDH1_uc003vmt.2_Missense_Mutation_p.A241V|IMPDH1_uc003vmu.2_Missense_Mutation_p.A351V|IMPDH1_uc003vmw.2_Missense_Mutation_p.A341V|IMPDH1_uc011kon.1_Missense_Mutation_p.A318V|IMPDH1_uc003vmv.2_Missense_Mutation_p.A315V|IMPDH1_uc003vmx.2_Missense_Mutation_p.A274V|IMPDH1_uc003vmy.2_Missense_Mutation_p.A282V	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	266	NAD (By similarity).				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	GTCGACGCCCGCCTGGGTGAG	0.602											OREG0018292	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	128038490	A	A	128038490	3	1	34	1	0	0	0	0	1	0	0	0	7726	1087	38	1	779	1	IMPDH1	7	128038490	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	21513844	128038490	31100173	35	2095											
CLCN1	1180	broad.mit.edu	37	chr7	143029823	143029823	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcctctcccagttgatgCcccgcgaagccatcagtact	7	16	3	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr7:143029823C>T	uc003wcr.1	+	12	1345	c.1258C>T	c.(1258-1260)CCC>TCC	p.P420S	CLCN1_uc011ktc.1_Intron	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	420					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CCAGTTGATGCCCCGCGAAGC	0.522													T	143029823	T	T	143029823	3	4	34	1	0	0	0	0	1	0	0	0	3462	739	26	3	1304	3	CLCN1	7	143029823	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	14991333	143029823	16108840	36	2096											
OR2F2	135948	broad.mit.edu	37	chr7	143632969	143632969	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gacacctttctgcctggttcTgttgtcctacatccggatca	8	13	3	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr7:143632969T>A	uc011ktv.1	+	1	644	c.644T>A	c.(643-645)CTG>CAG	p.L215Q		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					TGCCTGGTTCTGTTGTCCTAC	0.517													A	143632969	A	A	143632969	3	1	34	1	0	0	0	0	1	0	0	0	10997	1580	55	5	646	5	OR2F2	7	143632969	Missense_Mutation	SNP	T	TCGA-06-0173-01A-01D-1491-08	603146	143632969	15505694	37	2097											
CNTNAP2	26047	broad.mit.edu	37	chr7	147914464	147914464	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tgccagagactccagcagcaGagtagacaacgctcccgacc	10	15	0	3			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr7:147914464G>T	uc003weu.1	+	19	3611	c.3095G>T	c.(3094-3096)AGA>ATA	p.R1032I		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1032	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCCAGCAGCAGAGTAGACAAC	0.532										HNSCC(39;0.1)			T	147914464	T	T	147914464	3	4	34	1	0	0	0	0	1	0	0	0	3647	942	33	5	3169	5	CNTNAP2	7	147914464	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	4281495	147914464	11224199	38	2098											
UBE3C	9690	broad.mit.edu	37	chr7	156976584	156976584	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaaaggggccctctctgAggaagggctgctggtgtatt	15	8	1	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr7:156976584A>T	uc010lqs.2	+	9	1316	c.1004A>T	c.(1003-1005)GAG>GTG	p.E335V	UBE3C_uc003wnf.2_Missense_Mutation_p.E292V|UBE3C_uc003wng.2_Missense_Mutation_p.E335V	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	335					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		GCCCTCTCTGAGGAAGGGCTG	0.473													T	156976584	T	T	156976584	3	4	34	1	0	0	0	0	1	0	0	0	16878	304	11	5	1038	5	UBE3C	7	156976584	Missense_Mutation	SNP	A	TCGA-06-0173-01A-01D-1491-08	9062120	156976584	2162079	39	2099											
SCARA5	286133	broad.mit.edu	37	chr8	27737142	27737142	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccgcggaagccgagcatgCggcacaccacgtctccgtcc	11	18	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr8:27737142C>T	uc003xgj.2	-	8	1735	c.1295G>A	c.(1294-1296)CGC>CAC	p.R432H	SCARA5_uc010luz.2_Missense_Mutation_p.R207H	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	432	SRCR.|Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		GCCGAGCATGCGGCACACCAC	0.642													T	27737142	T	T	27737142	3	4	34	1	0	0	0	0	1	0	0	0	13880	768	27	1	200	1	SCARA5	8	27737142	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08		27737142	118626880	40	2100											
NRG1	3084	broad.mit.edu	37	chr8	31497984	31497984	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gggaggaggcgccctatctgGtgaaggtgcaccaggtgtgg	19	8	1	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr8:31497984G>C	uc003xip.2	+	1	717	c.484G>C	c.(484-486)GTG>CTG	p.V162L		NM_013962	NP_039256	Q02297	NRG1_HUMAN	neuregulin 1 isoform GGF2	Error:Variant_position_missing_in_Q02297_after_alignment					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GCCCTATCTGGTGAAGGTGCA	0.741													C	31497984	C	C	31497984	3	2	34	1	0	0	0	0	1	0	0	0	10647	1261	44	5	486	5	NRG1	8	31497984	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	3760842	31497984	114866038	41	2101											
SULF1	23213	broad.mit.edu	37	chr8	70515453	70515453	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acagatcgttctcaacattgActtggcccccacgatcctgg	8	14	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr8:70515453A>T	uc010lza.1	+	11	1805	c.1088A>T	c.(1087-1089)GAC>GTC	p.D363V	SULF1_uc003xyd.2_Missense_Mutation_p.D363V|SULF1_uc003xye.2_Missense_Mutation_p.D363V|SULF1_uc003xyf.2_Missense_Mutation_p.D363V|SULF1_uc003xyg.2_Missense_Mutation_p.D363V|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	363					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CTCAACATTGACTTGGCCCCC	0.537													T	70515453	T	T	70515453	3	4	34	1	0	0	0	0	1	0	0	0	15369	275	10	5	1114	5	SULF1	8	70515453	Missense_Mutation	SNP	A	TCGA-06-0173-01A-01D-1491-08	39017469	70515453	75848569	42	2102											
RIMS2	9699	broad.mit.edu	37	chr8	105001535	105001535	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagatcttgttgttttagtcGgaatgtggaacaggggcttc	13	5	1	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr8:105001535G>A	uc003yls.2	+	15	2505	c.2264G>A	c.(2263-2265)CGG>CAG	p.R755Q	RIMS2_uc003ylp.2_Missense_Mutation_p.R977Q|RIMS2_uc003ylw.2_Missense_Mutation_p.R769Q|RIMS2_uc003ylq.2_Missense_Mutation_p.R769Q|RIMS2_uc003ylr.2_Missense_Mutation_p.R816Q	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1039					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGTTTTAGTCGGAATGTGGAA	0.383										HNSCC(12;0.0054)			A	105001535	A	A	105001535	3	1	34	1	0	0	0	0	1	0	0	0	13368	1116	39	2	3122	2	RIMS2	8	105001535	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	34486082	105001535	41362487	43	2103											
EPPK1	83481	broad.mit.edu	37	chr8	144947336	144947336	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggcgtgccggctcccagcGtggctgccatggctctgggt	18	13	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr8:144947336G>A	uc003zaa.1	-	1	99	c.86C>T	c.(85-87)ACG>ATG	p.T29M		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	29						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGCTCCCAGCGTGGCTGCCAT	0.672													A	144947336	A	A	144947336	3	1	34	1	0	0	0	0	1	0	0	0	5190	1145	40	1	7180	1	EPPK1	8	144947336	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	39945801	144947336	1416686	44	2104											
C9orf66	157983	broad.mit.edu	37	chr9	214916	214916	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttccgcggctactctgcggcGcgccaggcccccgctttccg	12	19	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr9:214916G>A	uc003zge.3	-	1	978	c.481C>T	c.(481-483)CGC>TGC	p.R161C	DOCK8_uc011lls.1_5'UTR|DOCK8_uc003zgf.2_5'UTR	NM_152569	NP_689782	Q5T8R8	CI066_HUMAN	hypothetical protein LOC157983	161								p.R161C(1)		central_nervous_system(1)	1	all_lung(41;0.218)	all_cancers(5;2.09e-12)|all_epithelial(5;6.16e-09)|all_lung(10;1.15e-08)|Lung NSC(10;1.91e-08)|Acute lymphoblastic leukemia(5;0.00457)|all_hematologic(5;0.0332)|Breast(48;0.0646)|Prostate(43;0.137)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		ACTCTGCGGCGCGCCAGGCCC	0.687													A	214916	A	A	214916	3	1	34	1	0	0	0	0	1	0	0	0	2490	1087	38	1	410	1	C9orf66	9	214916	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08		214916	140998515	45	2105											
SUSD1	64420	broad.mit.edu	37	chr9	114874102	114874102	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgattccatagggtccaaccGttgtccttttatggatatct	8	9	1	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr9:114874102G>A	uc004bfu.2	-	8	1044	c.1003C>T	c.(1003-1005)CGG>TGG	p.R335W	SUSD1_uc010mui.2_Missense_Mutation_p.R335W|SUSD1_uc010muj.2_Missense_Mutation_p.R335W	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	335	Extracellular (Potential).					integral to membrane	calcium ion binding				0						GGGTCCAACCGTTGTCCTTTT	0.498													A	114874102	A	A	114874102	3	1	34	1	0	0	0	0	1	0	0	0	15404	1144	40	1	1280	1	SUSD1	9	114874102	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	114659186	114874102	26339329	46	2106											
LAMC3	10319	broad.mit.edu	37	chr9	133927946	133927946	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaccttccgggtgccccccGgggactccccactccctgta	10	19	0	1	rs142796007	byFrequency	TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr9:133927946G>A	uc004caa.1	+	10	1797	c.1699G>A	c.(1699-1701)GGG>AGG	p.G567R		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	567	Laminin IV type A.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GGTGCCCCCCGGGGACTCCCC	0.622											OREG0019556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	133927946	A	A	133927946	3	1	34	1	0	0	0	0	1	0	0	0	8616	1116	39	2	1737	2	LAMC3	9	133927946	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	19053844	133927946	7285485	47	2107											
ACTA2	59	broad.mit.edu	37	chr10	90699345	90699345	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacttgcccatcaggcaactCgtaactcttctcaagggagg	9	13	3	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr10:90699345C>T	uc001kfp.2	-	7	843	c.727G>A	c.(727-729)GAG>AAG	p.E243K	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.E198K|ACTA2_uc001kfq.2_Missense_Mutation_p.E243K|uc001kfo.1_RNA	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	243					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		TCAGGCAACTCGTAACTCTTC	0.512													T	90699345	T	T	90699345	3	4	34	1	0	0	0	0	1	0	0	0	192	893	31	2	418	2	ACTA2	10	90699345	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08		90699345	44835402	48	2108											
OR51E2	81285	broad.mit.edu	37	chr11	4703067	4703067	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgatctgtttggttttggcaCcatagatgatgggattgatg	13	4	1	4			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr11:4703067C>G	uc001lzk.2	-	2	1119	c.875G>C	c.(874-876)GGT>GCT	p.G292A		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GGTTTTGGCACCATAGATGAT	0.507													G	4703067	G	G	4703067	3	3	34	1	0	0	0	0	1	0	0	0	11095	507	18	5	91	5	OR51E2	11	4703067	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08		4703067	130303449	49	2109											
OR5I1	10798	broad.mit.edu	37	chr11	55703533	55703533	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggccatggcggccaggatgAaggattctgtatctgcaaaa	13	8	2	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr11:55703533A>T	uc010ris.1	-	1	344	c.344T>A	c.(343-345)TTC>TAC	p.F115Y		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGCCAGGATGAAGGATTCTGT	0.433													T	55703533	T	T	55703533	3	4	34	1	0	0	0	0	1	0	0	0	11164	246	9	5	603	5	OR5I1	11	55703533	Missense_Mutation	SNP	A	TCGA-06-0173-01A-01D-1491-08	51000466	55703533	79302983	50	2110											
AHNAK	79026	broad.mit.edu	37	chr11	62285595	62285595	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacacctggccccttcagttCgccagaaacctgtggcccct	8	18	1	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr11:62285595C>T	uc001ntl.2	-	5	16594	c.16294G>A	c.(16294-16296)GAA>AAA	p.E5432K	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5432					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCCTTCAGTTCGCCAGAAACC	0.527													T	62285595	T	T	62285595	3	4	34	1	0	0	0	0	1	0	0	0	414	893	31	2	1498	2	AHNAK	11	62285595	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	6582062	62285595	72720921	51	2111											
SLC22A9	114571	broad.mit.edu	37	chr11	63174115	63174115	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actgaaatacatgaaccgtcGagcaagccagatgcttctca	8	11	1	3			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr11:63174115G>A	uc001nww.2	+	7	1488	c.1220G>A	c.(1219-1221)CGA>CAA	p.R407Q	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	407	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						ATGAACCGTCGAGCAAGCCAG	0.483													A	63174115	A	A	63174115	3	1	34	1	0	0	0	0	1	0	0	0	14461	1058	37	2	1246	2	SLC22A9	11	63174115	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	888520	63174115	71832401	52	2112											
KIAA1377	57562	broad.mit.edu	37	chr11	101815013	101815013	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tagagcttttgaggagaaacGaaaagaacaggaagaaaaag	12	3	0	5	rs145886481		TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr11:101815013G>A	uc001pgm.2	+	3	536	c.266G>A	c.(265-267)CGA>CAA	p.R89Q	KIAA1377_uc001pgn.2_Missense_Mutation_p.R45Q|KIAA1377_uc009yxa.1_5'UTR	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	89	Potential.						protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GAGGAGAAACGAAAAGAACAG	0.308													A	101815013	A	A	101815013	3	1	34	1	0	0	0	0	1	0	0	0	8227	1058	37	2	276	2	KIAA1377	11	101815013	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	38640898	101815013	33191503	53	2113											
UBASH3B	84959	broad.mit.edu	37	chr11	122653798	122653798	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cataagaagcagctacatgtGaccctggcttaccacttcca	7	13	0	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr11:122653798G>A	uc001pyi.3	+	5	999	c.639G>A	c.(637-639)GTG>GTA	p.V213V		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	213						cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		AGCTACATGTGACCCTGGCTT	0.473													A	122653798	A	A	122653798	2	1	34	1	0	0	0	0	0	0	0	1	16837	1277	45	3		3	UBASH3B	11	122653798	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	20838785	122653798	12352718	54	2114											
APLP2	334	broad.mit.edu	37	chr11	130005535	130005535	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agacccctgtggacgtccggGtgagctctgaggagagtgag	17	9	1	5			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr11:130005535G>A	uc010sby.1	+	13	1919	c.1762G>A	c.(1762-1764)GTG>ATG	p.V588M	APLP2_uc001qfp.2_Missense_Mutation_p.V588M|APLP2_uc001qfq.2_Missense_Mutation_p.V532M|APLP2_uc010sbz.1_Missense_Mutation_p.V376M|APLP2_uc001qfr.2_Missense_Mutation_p.V354M|APLP2_uc001qfs.2_Missense_Mutation_p.V359M|APLP2_uc001qfv.2_Missense_Mutation_p.V479M	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	588	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		GGACGTCCGGGTGAGCTCTGA	0.592													A	130005535	A	A	130005535	3	1	34	1	0	0	0	0	1	0	0	0	779	1261	44	3	1812	3	APLP2	11	130005535	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	7351737	130005535	5000981	55	2115											
CAPRIN2	65981	broad.mit.edu	37	chr12	30888067	30888067	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	actgaacttgaagtatagttCgaagctttttcttctcagcc	7	9	2	2	rs139487645	byFrequency	TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr12:30888067C>T	uc001rji.1	-	4	1395	c.644G>A	c.(643-645)CGA>CAA	p.R215Q	CAPRIN2_uc001rjf.1_Missense_Mutation_p.R12Q|CAPRIN2_uc001rjg.1_5'UTR|CAPRIN2_uc001rjh.1_Missense_Mutation_p.R215Q|CAPRIN2_uc001rjj.1_5'UTR|CAPRIN2_uc001rjk.3_Missense_Mutation_p.R215Q|CAPRIN2_uc001rjl.3_Missense_Mutation_p.R215Q	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	215	Potential.				negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AAGTATAGTTCGAAGCTTTTT	0.413													T	30888067	T	T	30888067	3	4	34	1	0	0	0	0	1	0	0	0	2636	884	31	2	2799	2	CAPRIN2	12	30888067	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08		30888067	102963828	56	2116											
OR6C3	254786	broad.mit.edu	37	chr12	55725701	55725701	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagaaatctcatttacaaccGtatgcatccccagatttctg	5	11	2	2	rs139430640		TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr12:55725701G>A	uc010spj.1	+	1	217	c.217G>A	c.(217-219)GTA>ATA	p.V73I		NM_054104	NP_473445	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C,	73	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATTTACAACCGTATGCATCCC	0.428													A	55725701	A	A	55725701	3	1	34	1	0	0	0	0	1	0	0	0	11192	1145	40	1	219	1	OR6C3	12	55725701	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	24837634	55725701	78126194	57	2117											
PPFIA2	8499	broad.mit.edu	37	chr12	81747072	81747072	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	aagggtggctgcttagtactCcaatctgttgagttctattc	10	8	2	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr12:81747072C>A	uc001szo.1	-	17	1981	c.1820G>T	c.(1819-1821)GGA>GTA	p.G607V	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	533								p.G607G(1)		ovary(3)|lung(2)|pancreas(1)	6						GCTTAGTACTCCAATCTGTTG	0.368													A	81747072	A	A	81747072	3	1	34	1	0	0	0	0	1	0	0	0	12310	855	30	5	2017	5	PPFIA2	12	81747072	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	26021371	81747072	52104823	58	2118											
ANO4	121601	broad.mit.edu	37	chr12	101520783	101520783	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtatgaagcagaactggaaCgtctccagaaggaacgaaag	12	7	1	3	rs139827573		TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr12:101520783C>T	uc010svm.1	+	27	3375	c.2803C>T	c.(2803-2805)CGT>TGT	p.R935C	ANO4_uc001thw.2_Missense_Mutation_p.R900C|ANO4_uc001thx.2_Missense_Mutation_p.R935C|ANO4_uc001thy.2_Missense_Mutation_p.R455C	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	935	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						AGAACTGGAACGTCTCCAGAA	0.483										HNSCC(74;0.22)			T	101520783	T	T	101520783	3	4	34	1	0	0	0	0	1	0	0	0	699	536	19	1	2796	1	ANO4	12	101520783	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	19773711	101520783	32331112	59	2119											
TMEM132D	121256	broad.mit.edu	37	chr12	130184923	130184923	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caggtagactttgtcccgcaGgatgtgggcttttagtttcc	12	9	0	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr12:130184923G>C	uc009zyl.1	-	2	728	c.400C>G	c.(400-402)CTG>GTG	p.L134V		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	134	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTGTCCCGCAGGATGTGGGCT	0.537													C	130184923	C	C	130184923	3	2	34	1	0	0	0	0	1	0	0	0	16044	991	35	5	2931	5	TMEM132D	12	130184923	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	28664140	130184923	3666972	60	2120											
FLT1	2321	broad.mit.edu	37	chr13	28931760	28931760	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggctttgcagtgatagacacCttcatcctcttctgtgactc	8	12	3	3			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr13:28931760C>A	uc001usb.3	-	15	2464	c.2179G>T	c.(2179-2181)GGT>TGT	p.G727C		NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	727	Ig-like C2-type 7.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity	p.G727C(1)		lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGATAGACACCTTCATCCTCT	0.448													A	28931760	A	A	28931760	3	1	34	1	0	0	0	0	1	0	0	0	5941	681	24	5	1901	5	FLT1	13	28931760	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08		28931760	86238118	61	2121											
ERCC5	2073	broad.mit.edu	37	chr13	103491945	103491945	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gggggaaatttgcattgcatCatagcattccagagacttaa	10	7	1	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr13:103491945C>T	uc001vpu.1	+	9	1364	c.1242C>T	c.(1240-1242)ATC>ATT	p.I414I	BIVM_uc001vps.2_Silent_p.I414I|BIVM_uc010agc.2_Silent_p.I192I|BIVM_uc001vpv.2_Silent_p.I185I	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	Error:Variant_position_missing_in_P28715_after_alignment					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TGCATTGCATCATAGCATTCC	0.398			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				T	103491945	T	T	103491945	2	4	34	1	0	0	0	0	0	0	0	1	5216	816	29	3		3	ERCC5	13	103491945	Silent	SNP	C	TCGA-06-0173-01A-01D-1491-08	74560185	103491945	11677933	62	2122											
ANKRD10	55608	broad.mit.edu	37	chr13	111532388	111532388	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgagcggggtcgtggaggGgaagtccaaatgtccattga	16	7	0	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr13:111532388G>A	uc001vrn.2	-	6	994	c.859C>T	c.(859-861)CCC>TCC	p.P287S	ANKRD10_uc001vrm.2_Missense_Mutation_p.P24S|ANKRD10_uc001vrl.2_RNA	NM_017664	NP_060134	Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	287										central_nervous_system(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			GTCGTGGAGGGGAAGTCCAAA	0.473													A	111532388	A	A	111532388	3	1	34	1	0	0	0	0	1	0	0	0	638	1232	43	3	407	3	ANKRD10	13	111532388	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	8040443	111532388	3637490	63	2123											
TGM5	9333	broad.mit.edu	37	chr15	43552685	43552685	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggttgaaggcctggccccGgcgaacaagcaggtggtcca	16	11	0	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr15:43552685G>A	uc001zrd.1	-	2	111	c.103C>T	c.(103-105)CGG>TGG	p.R35W	TGM5_uc001zre.1_Missense_Mutation_p.R35W	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	35					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GCCTGGCCCCGGCGAACAAGC	0.572													A	43552685	A	A	43552685	3	1	34	1	0	0	0	0	1	0	0	0	15830	1115	39	2	2107	2	TGM5	15	43552685	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08		43552685	58978707	64	2124											
PML	5371	broad.mit.edu	37	chr15	74315385	74315385	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctgggccgcgcgcgtgcCgagaccgaggagctgatccg	17	14	0	2	rs112627818		TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr15:74315385C>T	uc002awv.2	+	3	959	c.819C>T	c.(817-819)GCC>GCT	p.A273A	PML_uc002awm.2_Silent_p.A273A|PML_uc002awl.2_Silent_p.A273A|PML_uc002awj.1_Silent_p.A273A|PML_uc002awk.2_Silent_p.A273A|PML_uc002awn.2_Silent_p.A273A|PML_uc002awo.2_Silent_p.A273A|PML_uc002awp.2_Silent_p.A273A|PML_uc002awq.2_Silent_p.A273A|PML_uc002awr.2_Silent_p.A273A|PML_uc002aws.2_Silent_p.A273A|PML_uc002awt.2_Silent_p.A273A|PML_uc002awu.2_Silent_p.A273A|PML_uc010ule.1_Intron|PML_uc002aww.1_Silent_p.A188A|PML_uc002awx.2_Silent_p.A31A|PML_uc002awy.2_5'Flank	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	273					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding	p.A273A(1)		central_nervous_system(2)|kidney(2)|breast(1)	5						GCGCGCGTGCCGAGACCGAGG	0.716			T	RARA|PAX5	APL|ALL								T	74315385	T	T	74315385	2	4	34	1	0	0	0	0	0	0	0	1	12135	639	23	2		2	PML	15	74315385	Silent	SNP	C	TCGA-06-0173-01A-01D-1491-08	30762700	74315385	28216007	65	2125											
ZNF597	146434	broad.mit.edu	37	chr16	3490932	3490932	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gatcctcaaagagtattggtCcctgaaacacaagagcctgt	9	10	1	3	rs139189056	byFrequency	TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr16:3490932C>A	uc002cvd.2	-	3	219	c.35G>T	c.(34-36)GGA>GTA	p.G12V	NAT15_uc002cvh.3_5'Flank|NAT15_uc010uxb.1_5'Flank	NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	12					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGTATTGGTCCCTGAAACAC	0.507													A	3490932	A	A	3490932	3	1	34	1	0	0	0	0	1	0	0	0	18024	869	30	5	1247	5	ZNF597	16	3490932	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08		3490932	86863821	66	2126											
A2BP1	54715	broad.mit.edu	37	chr16	7568246	7568246	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggtatccccgcggaatacaCggcccctcatccccaccccg	8	21	1	0	rs146499343		TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr16:7568246C>T	uc002cys.2	+	5	1113	c.125C>T	c.(124-126)ACG>ATG	p.T42M	A2BP1_uc010buf.1_Missense_Mutation_p.T42M|A2BP1_uc002cyr.1_Missense_Mutation_p.T42M|A2BP1_uc002cyt.2_Missense_Mutation_p.T42M|A2BP1_uc010uxz.1_Missense_Mutation_p.T85M|A2BP1_uc010uya.1_Missense_Mutation_p.T78M|A2BP1_uc002cyv.1_Missense_Mutation_p.T42M|A2BP1_uc010uyb.1_Missense_Mutation_p.T42M|A2BP1_uc002cyw.2_Missense_Mutation_p.T62M|A2BP1_uc002cyy.2_Missense_Mutation_p.T62M|A2BP1_uc002cyx.2_Missense_Mutation_p.T62M|A2BP1_uc010uyc.1_Missense_Mutation_p.T62M	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	42					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		GCGGAATACACGGCCCCTCAT	0.637													T	7568246	T	T	7568246	3	4	34	1	0	0	0	0	1	0	0	0	3	536	19	1	222	1	A2BP1	16	7568246	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	4077314	7568246	82786507	67	2127											
ACSM1	116285	broad.mit.edu	37	chr16	20702408	20702408	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attccatcttggggctccaaAttctgataaagaccggcagc	9	11	2	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr16:20702408A>G	uc002dhm.1	-	1	171	c.103T>C	c.(103-105)TTT>CTT	p.F35L	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Missense_Mutation_p.F35L	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	35					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						GGGGCTCCAAATTCTGATAAA	0.498													G	20702408	G	G	20702408	3	3	34	1	0	0	0	0	1	0	0	0	182	101	4	4	1682	4	ACSM1	16	20702408	Missense_Mutation	SNP	A	TCGA-06-0173-01A-01D-1491-08	13134162	20702408	69652345	68	2128											
VWA3A	146177	broad.mit.edu	37	chr16	22142922	22142922	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaggtgggccctgaacctgCggtgtcggggcagcaggaac	18	11	0	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr16:22142922C>T	uc010vbq.1	+	19	1840	c.1744C>T	c.(1744-1746)CGG>TGG	p.R582W	VWA3A_uc010bxd.2_RNA|VWA3A_uc010bxc.2_Missense_Mutation_p.R590W	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	582	VWFA 1.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		CCTGAACCTGCGGTGTCGGGG	0.577													T	22142922	T	T	22142922	3	4	34	1	0	0	0	0	1	0	0	0	17237	759	27	1	1818	1	VWA3A	16	22142922	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	1440514	22142922	68211831	69	2129											
CD19	930	broad.mit.edu	37	chr16	28948983	28948983	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggatgaagagctgacccagCcggtcgccaggacaatgggt	15	10	0	3			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr16:28948983C>T	uc002drs.2	+	11	1473	c.1411C>T	c.(1411-1413)CCG>TCG	p.P471S	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.P471S	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	471	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						GCTGACCCAGCCGGTCGCCAG	0.577													T	28948983	T	T	28948983	3	4	34	1	0	0	0	0	1	0	0	0	2973	739	26	3	1453	3	CD19	16	28948983	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	6806061	28948983	61405770	70	2130											
MYBBP1A	10514	broad.mit.edu	37	chr17	4455265	4455265	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggtcagcaggggcagggcCgcgcccagcaggcggaaaca	17	12	1	0	rs149464957		TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr17:4455265C>T	uc002fyb.3	-	8	995	c.933G>A	c.(931-933)GCG>GCA	p.A311A	MYBBP1A_uc002fxz.3_Silent_p.A311A	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	311	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						GGGGCAGGGCCGCGCCCAGCA	0.632													T	4455265	T	T	4455265	2	4	34	1	0	0	0	0	0	0	0	1	10008	639	23	2		2	MYBBP1A	17	4455265	Silent	SNP	C	TCGA-06-0173-01A-01D-1491-08		4455265	76739945	71	2131											
DVL2	1856	broad.mit.edu	37	chr17	7132476	7132476	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaagcatgtcccctggcTcaatgcgcccgtcggccgcc	11	17	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr17:7132476T>C	uc002gez.1	-	8	1217	c.935A>G	c.(934-936)GAG>GGG	p.E312G	DVL2_uc010vtr.1_Missense_Mutation_p.E306G|DVL2_uc010vts.1_3'UTR	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	312	PDZ.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						GTCCCCTGGCTCAATGCGCCC	0.637													C	7132476	C	C	7132476	3	2	34	1	0	0	0	0	1	0	0	0	4836	1551	54	4	1307	4	DVL2	17	7132476	Missense_Mutation	SNP	T	TCGA-06-0173-01A-01D-1491-08	2677211	7132476	74062734	72	2132											
DNAH2	146754	broad.mit.edu	37	chr17	7674216	7674216	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttttggaggttattgagatgAttctcacagtgcagcgtcag	12	6	2	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr17:7674216A>T	uc002giu.1	+	26	4341	c.4327A>T	c.(4327-4329)ATT>TTT	p.I1443F		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1443	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TATTGAGATGATTCTCACAGT	0.493													T	7674216	T	T	7674216	3	4	34	1	0	0	0	0	1	0	0	0	4602	333	12	5	4429	5	DNAH2	17	7674216	Missense_Mutation	SNP	A	TCGA-06-0173-01A-01D-1491-08	541740	7674216	73520994	73	2133											
DNAH9	1770	broad.mit.edu	37	chr17	11523026	11523026	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaagagaaccaggaagtcaaGgaatgggatttccagtcttc	11	7	2	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr17:11523026G>T	uc002gne.2	+	6	1346	c.1278G>T	c.(1276-1278)AAG>AAT	p.K426N		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	426	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGGAAGTCAAGGAATGGGATT	0.502													T	11523026	T	T	11523026	3	4	34	1	0	0	0	0	1	0	0	0	4608	991	35	5	1300	5	DNAH9	17	11523026	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	3848810	11523026	69672184	74	2134											
FOXN1	8456	broad.mit.edu	37	chr17	26861357	26861357	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgttccggcagacagcaccCgatggctggaagaattctgt	12	11	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr17:26861357C>T	uc010crm.2	+	7	1134	c.936C>T	c.(934-936)CCC>CCT	p.P312P	FOXN1_uc002hbj.2_Silent_p.P312P	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	312	Fork-head.				defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					AGACAGCACCCGATGGCTGGA	0.552													T	26861357	T	T	26861357	2	4	34	1	0	0	0	0	0	0	0	1	6019	639	23	2		2	FOXN1	17	26861357	Silent	SNP	C	TCGA-06-0173-01A-01D-1491-08	15338331	26861357	54333853	75	2135											
SLFN13	146857	broad.mit.edu	37	chr17	33768202	33768202	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgactggtctgaaagtagtcCagaaagatccagagaactcc	10	9	1	5			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr17:33768202C>T	uc002hjk.1	-	4	2436	c.2106G>A	c.(2104-2106)CTG>CTA	p.L702L	SLFN13_uc010wch.1_Silent_p.L702L|SLFN13_uc002hjl.2_Silent_p.L702L|SLFN13_uc010ctt.2_Silent_p.L384L|SLFN13_uc002hjm.2_Silent_p.L371L	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	702						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GAAAGTAGTCCAGAAAGATCC	0.483													T	33768202	T	T	33768202	2	4	34	1	0	0	0	0	0	0	0	1	14736	581	21	3		3	SLFN13	17	33768202	Silent	SNP	C	TCGA-06-0173-01A-01D-1491-08	6906845	33768202	47427008	76	2136											
MYOM1	8736	broad.mit.edu	37	chr18	3067533	3067533	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggcgggtctccccacacGttgcaagtgagattaagggc	15	10	1	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr18:3067533G>A	uc002klp.2	-	38	5119	c.4785C>T	c.(4783-4785)AAC>AAT	p.N1595N	MYOM1_uc002klq.2_Silent_p.N1499N	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1595	Ig-like C2-type 5.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CTCCCCACACGTTGCAAGTGA	0.537													A	3067533	A	A	3067533	2	1	34	1	0	0	0	0	0	0	0	1	10091	1136	40	1		1	MYOM1	18	3067533	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08		3067533	75009715	77	2137											
ROCK1	6093	broad.mit.edu	37	chr18	18533573	18533573	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtatttttgaccactttccGgaaagactgatttgcagtgg	10	7	0	3			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr18:18533573G>A	uc002kte.2	-	32	4968	c.4027C>T	c.(4027-4029)CGG>TGG	p.R1343W		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1343	Auto-inhibitory.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					ACCACTTTCCGGAAAGACTGA	0.358													A	18533573	A	A	18533573	3	1	34	1	0	0	0	0	1	0	0	0	13517	1115	39	2	45	2	ROCK1	18	18533573	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	15466040	18533573	59543675	78	2138											
DSC3	1825	broad.mit.edu	37	chr18	28598687	28598687	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aatctgttactgttatgataCaagttgatgtgcctatcaat	7	6	2	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr18:28598687C>A	uc002kwj.3	-	8	1177	c.1022G>T	c.(1021-1023)TGT>TTT	p.C341F	DSC3_uc002kwi.3_Missense_Mutation_p.C341F	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	341	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TGTTATGATACAAGTTGATGT	0.338													A	28598687	A	A	28598687	3	1	34	1	0	0	0	0	1	0	0	0	4767	478	17	5	1735	5	DSC3	18	28598687	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	10065114	28598687	49478561	79	2139											
KIAA1632	57724	broad.mit.edu	37	chr18	43493732	43493732	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attccccttcaataactctcCggagctgggagtcctcttca	7	14	4	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr18:43493732C>T	uc002lbm.2	-	21	3855	c.3755G>A	c.(3754-3756)CGG>CAG	p.R1252Q	KIAA1632_uc002lbo.1_Missense_Mutation_p.R1252Q|KIAA1632_uc010xcq.1_5'UTR|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.R127Q	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1252					autophagy						0						AATAACTCTCCGGAGCTGGGA	0.488													T	43493732	T	T	43493732	3	4	34	1	0	0	0	0	1	0	0	0	8249	652	23	2	4080	2	KIAA1632	18	43493732	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	14895045	43493732	34583516	80	2140											
NETO1	81832	broad.mit.edu	37	chr18	70417298	70417298	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaatctattgatactgaccGctggacggctttatcgtgtc	9	9	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr18:70417298G>A	uc002lkw.2	-	9	1824	c.1540C>T	c.(1540-1542)CGG>TGG	p.R514W	NETO1_uc002lkx.1_Missense_Mutation_p.R513W|NETO1_uc002lky.1_Missense_Mutation_p.R514W	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	514	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GATACTGACCGCTGGACGGCT	0.433													A	70417298	A	A	70417298	3	1	34	1	0	0	0	0	1	0	0	0	10339	1101	38	1	69	1	NETO1	18	70417298	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	26923566	70417298	7659950	81	2141											
CHAF1A	10036	broad.mit.edu	37	chr19	4433232	4433232	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccacccccagcgaggatgCcgccatcccctctaagtccc	7	22	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:4433232C>T	uc002mal.2	+	13	2469	c.2369C>T	c.(2368-2370)GCC>GTC	p.A790V		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	790	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCGAGGATGCCGCCATCCCC	0.652								Chromatin_Structure					T	4433232	T	T	4433232	3	4	34	1	0	0	0	0	1	0	0	0	3311	739	26	3	2419	3	CHAF1A	19	4433232	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08		4433232	54695751	82	2142											
MUC16	94025	broad.mit.edu	37	chr19	9069201	9069201	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttcatcaccagggcggtgCtgtcctctttcagttcagga	11	11	5	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:9069201C>T	uc002mkp.2	-	3	18449	c.18245G>A	c.(18244-18246)AGC>AAC	p.S6082N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6084	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGGGCGGTGCTGTCCTCTTT	0.498													T	9069201	T	T	9069201	3	4	34	1	0	0	0	0	1	0	0	0	9973	797	28	3	25606	3	MUC16	19	9069201	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	4635969	9069201	50059782	83	2143											
CALR	811	broad.mit.edu	37	chr19	13051173	13051173	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaagacgattgggacttcctGccacccaagaagataaagga	11	9	0	3			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:13051173G>T	uc002mvu.2	+	5	689	c.609G>T	c.(607-609)CTG>CTT	p.L203L		NM_004343	NP_004334	P27797	CALR_HUMAN	calreticulin precursor	203	P-domain.|4 X approximate repeats.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGACTTCCTGCCACCCAAGA	0.532													T	13051173	T	T	13051173	2	4	34	1	0	0	0	0	0	0	0	1	2592	1306	46	5		5	CALR	19	13051173	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	3981972	13051173	46077810	84	2144											
CACNA1A	773	broad.mit.edu	37	chr19	13340971	13340971	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggcccaggatggaggagtctCgggtgaggtactcaaagttg	17	7	2	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:13340971C>T	uc010dze.2	-	36	5692	c.5456G>A	c.(5455-5457)CGA>CAA	p.R1819Q	CACNA1A_uc010xnd.1_Missense_Mutation_p.R524Q|CACNA1A_uc002mwx.3_Missense_Mutation_p.R524Q|CACNA1A_uc010dzc.2_Missense_Mutation_p.R1344Q|CACNA1A_uc002mwy.3_Missense_Mutation_p.R1818Q|CACNA1A_uc002mwv.3_Missense_Mutation_p.R335Q	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1819	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGAGGAGTCTCGGGTGAGGTA	0.597													T	13340971	T	T	13340971	3	4	34	1	0	0	0	0	1	0	0	0	2538	884	31	2	2216	2	CACNA1A	19	13340971	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	289798	13340971	45788012	85	2145											
ZNF681	148213	broad.mit.edu	37	chr19	23927348	23927348	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcacatttgtagggtttcTctccagtatgaattatctta	6	8	3	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:23927348T>C	uc002nrk.3	-	4	1146	c.1004A>G	c.(1003-1005)GAG>GGG	p.E335G	ZNF681_uc002nrl.3_Missense_Mutation_p.E266G|ZNF681_uc002nrj.3_Missense_Mutation_p.E266G	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				GTAGGGTTTCTCTCCAGTATG	0.393													C	23927348	C	C	23927348	3	2	34	1	0	0	0	0	1	0	0	0	18085	1551	54	4	937	4	ZNF681	19	23927348	Missense_Mutation	SNP	T	TCGA-06-0173-01A-01D-1491-08	10586377	23927348	35201635	86	2146											
CAPNS1	826	broad.mit.edu	37	chr19	36633602	36633602	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggccaacgagagtgaggagGtccggcagttccggagactc	16	10	0	3			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:36633602G>T	uc002odj.2	+	4	449	c.292G>T	c.(292-294)GTC>TTC	p.V98F	CAPNS1_uc002odi.1_Missense_Mutation_p.V98F|CAPNS1_uc002odk.2_Missense_Mutation_p.V98F|CAPNS1_uc002odl.2_Missense_Mutation_p.V98F	NM_001749	NP_001740	P04632	CPNS1_HUMAN	calpain, small subunit 1	98	EF-hand 1; atypical.				positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GAGTGAGGAGGTCCGGCAGTT	0.622													T	36633602	T	T	36633602	3	4	34	1	0	0	0	0	1	0	0	0	2633	1261	44	5	302	5	CAPNS1	19	36633602	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	12706254	36633602	22495381	87	2147											
CEACAM4	1089	broad.mit.edu	37	chr19	42132051	42132051	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtagggtgtaggatcctgcGtcctccagggtgatgttttg	15	8	0	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:42132051G>A	uc002orh.1	-	2	459	c.348C>T	c.(346-348)GAC>GAT	p.D116D	CEACAM4_uc010xwd.1_Silent_p.D116D	NM_001817	NP_001808	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion	116	Extracellular (Potential).|Ig-like V-type.					integral to plasma membrane|membrane fraction					0						AGGATCCTGCGTCCTCCAGGG	0.522													A	42132051	A	A	42132051	2	1	34	1	0	0	0	0	0	0	0	1	3194	1136	40	1		1	CEACAM4	19	42132051	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	5498449	42132051	16996932	88	2148											
ZNF229	7772	broad.mit.edu	37	chr19	44933285	44933285	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgatggatgtggaggtcGgagctccggccaaagctctt	14	10	2	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:44933285G>A	uc002oze.1	-	6	2105	c.1671C>T	c.(1669-1671)TCC>TCT	p.S557S	ZNF229_uc010ejk.1_Silent_p.S211S|ZNF229_uc010ejl.1_Silent_p.S551S	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	557	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				TGTGGAGGTCGGAGCTCCGGC	0.542													A	44933285	A	A	44933285	2	1	34	1	0	0	0	0	0	0	0	1	17779	1103	39	2		2	ZNF229	19	44933285	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	2801234	44933285	14195698	89	2149											
CEACAM20	125931	broad.mit.edu	37	chr19	45021184	45021184	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcagcacctggcttggactCggcccaacactgcagggtca	11	15	2	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:45021184C>T	uc010ejn.1	-	6	1148	c.1132G>A	c.(1132-1134)GAG>AAG	p.E378K	CEACAM20_uc010ejo.1_Missense_Mutation_p.E378K|CEACAM20_uc010ejp.1_Intron|CEACAM20_uc010ejq.1_Intron	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	378	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				GGCTTGGACTCGGCCCAACAC	0.582													T	45021184	T	T	45021184	3	4	34	1	0	0	0	0	1	0	0	0	3191	893	31	2	687	2	CEACAM20	19	45021184	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	87899	45021184	14107799	90	2150											
LIG1	3978	broad.mit.edu	37	chr19	48668866	48668866	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgtccagcacttttcttcGtctgtcagctgctcctggaa	8	14	3	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:48668866G>A	uc002pia.1	-	2	78	c.-42C>T	c.(-44--40)GACGA>GATGA		LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Translation_Start_Site|LIG1_uc010xzg.1_Translation_Start_Site|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I						anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	ACTTTTCTTCGTCTGTCAGCT	0.463								NER					A	48668866	A	A	48668866	1	1	34	1	0	0	0	0	0	0	0	0	8781	1160	40	1		1	LIG1	19	48668866	Translation_Start_Site	SNP	G	TCGA-06-0173-01A-01D-1491-08	3647682	48668866	10460117	91	2151											
LILRB5	10990	broad.mit.edu	37	chr19	54756388	54756388	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccttgggctctggccccgcaGcccctgcaggacggtagaaa	13	15	1	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:54756388G>T	uc002qex.2	-	10	1607	c.1496C>A	c.(1495-1497)GCT>GAT	p.A499D	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.A491D|LILRB5_uc002qey.2_Missense_Mutation_p.A500D|LILRB5_uc002qez.2_Missense_Mutation_p.A400D|LILRB5_uc002qfa.1_3'UTR	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	499	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGCCCCGCAGCCCCTGCAGG	0.607													T	54756388	T	T	54756388	3	4	34	1	0	0	0	0	1	0	0	0	8794	971	34	5	292	5	LILRB5	19	54756388	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	6087522	54756388	4372595	92	2152											
LENG8	114823	broad.mit.edu	37	chr19	54967619	54967619	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggcccatatggatcggggcCgaggcagggcgcagcgtggg	21	10	0	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:54967619C>A	uc002qfv.1	+	9	1453	c.1309C>A	c.(1309-1311)CGA>AGA	p.R437R	LENG8_uc002qfw.2_Silent_p.R474R			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	437							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GGATCGGGGCCGAGGCAGGGC	0.682													A	54967619	A	A	54967619	2	1	34	1	0	0	0	0	0	0	0	1	8724	644	23	5		5	LENG8	19	54967619	Silent	SNP	C	TCGA-06-0173-01A-01D-1491-08	211231	54967619	4161364	93	2153											
LILRB1	10859	broad.mit.edu	37	chr19	55146733	55146733	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagcccagctgccgatgcccAggaagaaaacctctgtgagt	11	13	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:55146733A>G	uc002qgj.2	+	13	1923	c.1583A>G	c.(1582-1584)CAG>CGG	p.Q528R	LILRB1_uc010erp.1_Missense_Mutation_p.Q143R|LILRB1_uc002qgl.2_Missense_Mutation_p.Q528R|LILRB1_uc002qgk.2_Missense_Mutation_p.Q529R|LILRB1_uc002qgm.2_Missense_Mutation_p.Q529R|LILRB1_uc010erq.2_Missense_Mutation_p.Q512R|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	528	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GCCGATGCCCAGGAAGAAAAC	0.612										HNSCC(37;0.09)			G	55146733	G	G	55146733	3	3	34	1	0	0	0	0	1	0	0	0	8790	188	7	4	1628	4	LILRB1	19	55146733	Missense_Mutation	SNP	A	TCGA-06-0173-01A-01D-1491-08	179114	55146733	3982250	94	2154											
GALP	85569	broad.mit.edu	37	chr19	56691958	56691958	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgcatctctatccagggaCgaggaggctggaccctcaat	11	12	3	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr19:56691958C>T	uc002qmo.1	+	3	173	c.91C>T	c.(91-93)CGA>TGA	p.R31*	GALP_uc010eti.2_Intron	NM_033106	NP_149097	Q9UBC7	GALP_HUMAN	galanin-like peptide isoform 1 precursor	31					neuropeptide signaling pathway	extracellular region	hormone activity				0		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		TATCCAGGGACGAGGAGGCTG	0.602													T	56691958	T	T	56691958	4	4	34	1	0	0	0	0	0	1	0	0	6226	528	19	1	97	1	GALP	19	56691958	Nonsense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	1545225	56691958	2437025	95	2155											
SDC4	6385	broad.mit.edu	37	chr20	43977015	43977016	+	Frame_Shift_Ins	INS	-	G	G													agcagcgcgaacagacgggcINSgggggccatggcaccgcgga							TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr20:43977015_43977016insG	uc002xnu.2	-	1	49_50	c.9_10insC	c.(7-12)CCCGCCfs	p.P3fs	SDC4_uc010zws.1_5'UTR	NM_002999	NP_002990	P31431	SDC4_HUMAN	syndecan 4 precursor	3_4						extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity				0		Myeloproliferative disorder(115;0.0122)				AACAGACGGGCGGGGGCCATGG	0.708													G	43977016	G	G	43977015	7	5	34	1	0	1	1	0	0	0	0	0	13954	768	27	0	606	0	SDC4	20	43977015	Frame_Shift_Ins	INS	-	TCGA-06-0173-01A-01D-1491-08		43977015	19048505	96	2156											
PARD6B	84612	broad.mit.edu	37	chr20	49366649	49366649	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcatcataacagtgagacCggcaaaccagaggaataatg	9	10	2	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr20:49366649C>T	uc002xvo.2	+	3	986	c.743C>T	c.(742-744)CCG>CTG	p.P248L		NM_032521	NP_115910	Q9BYG5	PAR6B_HUMAN	PAR-6 beta	248	PDZ.|Interaction with PARD3 and CDC42 (By similarity).				axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			kidney(1)	1						ACAGTGAGACCGGCAAACCAG	0.443													T	49366649	T	T	49366649	3	4	34	1	0	0	0	0	1	0	0	0	11446	652	23	2	753	2	PARD6B	20	49366649	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08	5389634	49366649	13658871	97	2157											
RTEL1	51750	broad.mit.edu	37	chr20	62316891	62316891	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttcagattgtgttcagtgtgGacccctccgagggcagccct	12	12	2	1			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr20:62316891G>A	uc002yfu.1	+	15	1550	c.1207G>A	c.(1207-1209)GAC>AAC	p.D403N	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.D403N|RTEL1_uc011abd.1_Missense_Mutation_p.D427N|RTEL1_uc011abe.1_Missense_Mutation_p.D180N|RTEL1_uc002yfw.2_RNA	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	403					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GTTCAGTGTGGACCCCTCCGA	0.627													A	62316891	A	A	62316891	3	1	34	1	0	0	0	0	1	0	0	0	13720	1174	41	3	1261	3	RTEL1	20	62316891	Missense_Mutation	SNP	G	TCGA-06-0173-01A-01D-1491-08	12950242	62316891	708629	98	2158											
TXNRD2	10587	broad.mit.edu	37	chr22	19870868	19870868	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccaccacgtcaccaatggCgtagatgtggggcacagagg	13	12	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chr22:19870868C>T	uc011ahc.1	-	12	1099	c.1066G>A	c.(1066-1068)GCC>ACC	p.A356T	TXNRD2_uc002zql.1_Missense_Mutation_p.A110T|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Missense_Mutation_p.A355T|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_5'Flank	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	356					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					TCACCAATGGCGTAGATGTGG	0.647													T	19870868	T	T	19870868	3	4	34	1	0	0	0	0	1	0	0	0	16805	768	27	1	532	1	TXNRD2	22	19870868	Missense_Mutation	SNP	C	TCGA-06-0173-01A-01D-1491-08		19870868	31433698	99	2159											
NDUFB11	54539	broad.mit.edu	37	chrX	47001797	47001797	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggccattggcctctcggtaTttcacaagcctctcagcttc	8	14	3	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chrX:47001797T>C	uc004dhd.2	-	3	912	c.381A>G	c.(379-381)AAA>AAG	p.K127K	NDUFB11_uc004dhc.2_Silent_p.K137K|RBM10_uc004dhe.1_5'Flank|RBM10_uc004dhf.2_5'Flank|RBM10_uc004dhg.2_5'Flank|RBM10_uc004dhh.2_5'Flank|RBM10_uc010nhq.2_5'Flank|RBM10_uc004dhi.2_5'Flank	NM_001135998	NP_001129470	Q9NX14	NDUBB_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	127					respiratory electron transport chain|transport	integral to membrane|mitochondrial respiratory chain complex I					0						CCTCTCGGTATTTCACAAGCC	0.552													C	47001797	C	C	47001797	2	2	34	1	0	0	0	0	0	0	0	1	10280	1490	52	4		4	NDUFB11	23	47001797	Silent	SNP	T	TCGA-06-0173-01A-01D-1491-08		47001797	108268763	100	2160											
GATA1	2623	broad.mit.edu	37	chrX	48652346	48652346	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctttatggtggtggctggGggcagcggtagcgggaattg	21	5	0	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chrX:48652346G>A	uc004dkq.3	+	6	1108	c.1017G>A	c.(1015-1017)GGG>GGA	p.G339G		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	339					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						TGGTGGCTGGGGGCAGCGGTA	0.627			Mis|F		megakaryoblastic leukemia of Downs Syndrome								A	48652346	A	A	48652346	2	1	34	1	0	0	0	0	0	0	0	1	6253	1219	43	3		3	GATA1	23	48652346	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	1650549	48652346	106618214	101	2161											
YIPF6	286451	broad.mit.edu	37	chrX	67742719	67742719	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctgtaaacttcatggttcgGctttttgtggtgattgtgat	11	6	1	2			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chrX:67742719G>T	uc004dwy.2	+	6	575	c.552G>T	c.(550-552)CGG>CGT	p.R184R	YIPF6_uc011mph.1_Silent_p.R141R	NM_173834	NP_776195	Q96EC8	YIPF6_HUMAN	Yip1 domain family, member 6	184						endoplasmic reticulum|integral to membrane					0						TCATGGTTCGGCTTTTTGTGG	0.408													T	67742719	T	T	67742719	2	4	34	1	0	0	0	0	0	0	0	1	17479	1190	42	5		5	YIPF6	23	67742719	Silent	SNP	G	TCGA-06-0173-01A-01D-1491-08	19090373	67742719	87527841	102	2162											
CDX4	1046	broad.mit.edu	37	chrX	72667262	72667262	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcactatatggggtatcctcAtatgcccagcatggatcctc	9	12	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chrX:72667262A>G	uc011mqk.1	+	1	173	c.173A>G	c.(172-174)CAT>CGT	p.H58R		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	58						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					GGGTATCCTCATATGCCCAGC	0.632													G	72667262	G	G	72667262	3	3	34	1	0	0	0	0	1	0	0	0	3184	217	8	4	175	4	CDX4	23	72667262	Missense_Mutation	SNP	A	TCGA-06-0173-01A-01D-1491-08	4924543	72667262	82603298	103	2163											
CPXCR1	53336	broad.mit.edu	37	chrX	88009244	88009244	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaataatggttggaaatacTtttgtcccatctgtggaagg	10	7	1	0			TCGA-06-0173-01A-01D-1491-08	TCGA-06-0173-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	0908aac1-d3b7-4eec-96f2-a28c3738388c	ef93fb90-a2ac-473c-aa3d-66ccd0a4f147	g.chrX:88009244T>C	uc004efd.3	+	3	1088	c.829T>C	c.(829-831)TTT>CTT	p.F277L	CPXCR1_uc004efc.3_Missense_Mutation_p.F277L	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	277						intracellular	zinc ion binding			ovary(3)	3						TTGGAAATACTTTTGTCCCAT	0.299													C	88009244	C	C	88009244	3	2	34	1	0	0	0	0	1	0	0	0	3836	1609	56	4	831	4	CPXCR1	23	88009244	Missense_Mutation	SNP	T	TCGA-06-0173-01A-01D-1491-08	15341982	88009244	67261316	104	2164											
TNFRSF4	7293	broad.mit.edu	37	chr1	1149465	1149465	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggcccaggaggagcagagCcgcacacggcccgcggccca	15	17	0	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:1149465C>T	uc001ade.2	-	1	48	c.43G>A	c.(43-45)GCT>ACT	p.A15T	TNFRSF4_uc001adf.2_5'UTR	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	15					immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGGAGCAGAGCCGCACACGGC	0.692													T	1149465	T	T	1149465	3	4	35	1	0	0	0	0	1	0	0	0	16294	739	26	3	818	3	TNFRSF4	1	1149465	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08		1149465	248101156	1	2165											
SLC25A34	284723	broad.mit.edu	37	chr1	16065774	16065775	+	Frame_Shift_Ins	INS	-	C	C													aagatctggcggcaggagggINSccccctggcactctacaagg							TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:16065774_16065775insC	uc001axb.1	+	5	960_961	c.788_789insC	c.(787-789)GGCfs	p.G263fs	SLC25A34_uc009vok.1_RNA	NM_207348	NP_997231	Q6PIV7	S2534_HUMAN	solute carrier family 25, member 34	263	Solcar 3.				transport	integral to membrane|mitochondrial inner membrane					0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CGGCAGGAGGGCCCCCTGGCAC	0.649													C	16065775	C	C	16065774	7	5	35	1	0	1	1	0	0	0	0	0	14498	1203	42	0	806	0	SLC25A34	1	16065774	Frame_Shift_Ins	INS	-	TCGA-06-0174-01A-01D-1491-08	14916309	16065774	233184847	2	2166											
C1orf201	90529	broad.mit.edu	37	chr1	24710467	24710467	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtgactggtgaataacattGtagaacccaggtcctgggat	13	7	0	3			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:24710467G>T	uc001bjc.2	-	4	351	c.216C>A	c.(214-216)TAC>TAA	p.Y72*	C1orf201_uc001bja.2_Nonsense_Mutation_p.Y25*|C1orf201_uc001bjb.2_5'UTR|C1orf201_uc001bjd.2_Nonsense_Mutation_p.Y72*|C1orf201_uc001bje.1_Nonsense_Mutation_p.Y25*|C1orf201_uc001bjf.2_5'UTR			Q5TH74	CA201_HUMAN	RecName: Full=UPF0490 protein C1orf201;	72										ovary(1)|breast(1)	2		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.0191)|all_lung(284;0.0251)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.056)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.48e-25)|Colorectal(126;7.29e-08)|COAD - Colon adenocarcinoma(152;3.85e-06)|GBM - Glioblastoma multiforme(114;0.000399)|BRCA - Breast invasive adenocarcinoma(304;0.00107)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00393)|READ - Rectum adenocarcinoma(331;0.0672)|Lung(427;0.145)		GAATAACATTGTAGAACCCAG	0.413													T	24710467	T	T	24710467	4	4	35	1	0	0	0	0	0	1	0	0	2027	1372	48	5	812	5	C1orf201	1	24710467	Nonsense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	8644693	24710467	224540154	3	2167											
LEPRE1	64175	broad.mit.edu	37	chr1	43213879	43213879	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccgcactcacctgtagtcGcggaaggtgtaggctggggg	16	12	1	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:43213879G>A	uc001chv.2	-	12	1943	c.1830C>T	c.(1828-1830)CGC>CGT	p.R610R	LEPRE1_uc001chw.2_Silent_p.R610R|LEPRE1_uc001chx.3_Silent_p.R610R	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	610	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ACCTGTAGTCGCGGAAGGTGT	0.602													A	43213879	A	A	43213879	2	1	35	1	0	0	0	0	0	0	0	1	8729	1074	38	1		1	LEPRE1	1	43213879	Silent	SNP	G	TCGA-06-0174-01A-01D-1491-08	18503412	43213879	206036742	4	2168											
TOE1	114034	broad.mit.edu	37	chr1	45808763	45808764	+	Frame_Shift_Ins	INS	-	G	G													ccacccctaggcttatggctINSggtgccccctgggaccacag							TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:45808763_45808764insG	uc009vxq.2	+	8	1505_1506	c.922_923insG	c.(922-924)TGGfs	p.W308fs	MUTYH_uc001cnj.2_5'Flank|MUTYH_uc001cni.2_5'Flank|MUTYH_uc001cnh.2_5'Flank|MUTYH_uc001cno.2_5'Flank|MUTYH_uc001cnk.2_5'Flank|MUTYH_uc010oll.1_5'Flank|MUTYH_uc001cnm.2_5'Flank|MUTYH_uc001cnl.2_5'Flank|MUTYH_uc009vxp.2_5'Flank|MUTYH_uc001cnn.2_5'Flank|TOE1_uc001cnq.3_RNA|TOE1_uc010olm.1_Frame_Shift_Ins_p.W228fs|TOE1_uc001cnr.3_RNA	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	308	C3H1-type.					nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					GGCTTATGGCTGGTGCCCCCTG	0.569													G	45808764	G	G	45808763	7	5	35	1	0	1	1	0	0	0	0	0	16346	1580	55	0	952	0	TOE1	1	45808763	Frame_Shift_Ins	INS	-	TCGA-06-0174-01A-01D-1491-08	2594884	45808763	203441858	5	2169											
GIPC2	54810	broad.mit.edu	37	chr1	78560730	78560730	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaaaatattgttgggtggcGtcactatgatgttgctaaga	12	4	1	3	rs143579527		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:78560730G>A	uc001dik.2	+	3	711	c.521G>A	c.(520-522)CGT>CAT	p.R174H		NM_017655	NP_060125	Q8TF65	GIPC2_HUMAN	PDZ domain protein GIPC2	174	PDZ.					cytoplasm				ovary(1)	1						GTTGGGTGGCGTCACTATGAT	0.348													A	78560730	A	A	78560730	3	1	35	1	0	0	0	0	1	0	0	0	6393	1145	40	1	531	1	GIPC2	1	78560730	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	32751967	78560730	170689891	6	2170											
POLR3C	10623	broad.mit.edu	37	chr1	145594170	145594170	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atgatggcttctaccctctgAgatttttctagtagacgcct	8	10	3	3			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:145594170A>T	uc001eoh.2	-	14	1553	c.1392T>A	c.(1390-1392)TCT>TCA	p.S464S	NBPF10_uc001emp.3_Intron|POLR3C_uc001eog.2_Silent_p.S477S|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Intron	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	464					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			CTACCCTCTGAGATTTTTCTA	0.478													T	145594170	T	T	145594170	2	4	35	1	0	0	0	0	0	0	0	1	12230	291	11	5		5	POLR3C	1	145594170	Silent	SNP	A	TCGA-06-0174-01A-01D-1491-08	67033440	145594170	103656451	7	2171											
VPS72	6944	broad.mit.edu	37	chr1	151162515	151162515	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cataagtcgtctggtagaacTcatcttcctcctctgcctcc	6	15	4	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:151162515T>C	uc001exe.1	-	1	126	c.83A>G	c.(82-84)GAG>GGG	p.E28G	VPS72_uc001exf.1_Missense_Mutation_p.E28G	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	28	Asp/Glu-rich (acidic).				chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGGTAGAACTCATCTTCCTC	0.612													C	151162515	C	C	151162515	3	2	35	1	0	0	0	0	1	0	0	0	17214	1551	54	4	1035	4	VPS72	1	151162515	Missense_Mutation	SNP	T	TCGA-06-0174-01A-01D-1491-08	5568345	151162515	98088106	8	2172											
LRRC52	440699	broad.mit.edu	37	chr1	165532851	165532851	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acgcacctggaccacaaagaCtacatcttcctgctgctcat	6	15	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:165532851C>A	uc001gde.2	+	2	788	c.732C>A	c.(730-732)GAC>GAA	p.D244E	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	244	Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					ACCACAAAGACTACATCTTCC	0.602													A	165532851	A	A	165532851	3	1	35	1	0	0	0	0	1	0	0	0	9010	564	20	5	738	5	LRRC52	1	165532851	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	14370336	165532851	83717770	9	2173											
SELE	6401	broad.mit.edu	37	chr1	169698757	169698757	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccatgggaagcttccagggTtttggaaacattccacgaac	10	10	0	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr1:169698757T>C	uc001ggm.3	-	6	930	c.773A>G	c.(772-774)AAC>AGC	p.N258S	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	258	Sushi 2.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GCTTCCAGGGTTTTGGAAACA	0.438													C	169698757	C	C	169698757	3	2	35	1	0	0	0	0	1	0	0	0	14013	1725	60	4	1091	4	SELE	1	169698757	Missense_Mutation	SNP	T	TCGA-06-0174-01A-01D-1491-08	4165906	169698757	79551864	10	2174											
XDH	7498	broad.mit.edu	37	chr2	31595165	31595165	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcgtagcgaggaatgtcGtcacagtacacggcctcacc	10	13	3	0	rs140066757		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr2:31595165G>A	uc002rnv.1	-	17	1864	c.1785C>T	c.(1783-1785)GAC>GAT	p.D595D		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	595					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GAGGAATGTCGTCACAGTACA	0.647													A	31595165	A	A	31595165	2	1	35	1	0	0	0	0	0	0	0	1	17423	1136	40	1		1	XDH	2	31595165	Silent	SNP	G	TCGA-06-0174-01A-01D-1491-08		31595165	211604208	11	2175											
STRN	6801	broad.mit.edu	37	chr2	37121134	37121153	+	Frame_Shift_Del	DEL	CTCGATCTTCACCGCTGTCA	-	-													ctttagagcttcttttgtatCtcgatcttcaccgctgtcag							TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr2:37121134_37121153delCTCGATCTTCACCGCTGTCA	uc002rpn.2	-	7	828_847	c.819_838delTGACAGCGGTGAAGATCGAG	c.(817-840)CCTGACAGCGGTGAAGATCGAGATfs	p.P273fs	STRN_uc010ezx.2_Frame_Shift_Del_p.P273fs	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	273_280					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TCTTTTGTATCTCGATCTTCACCGCTGTCAGGCAATGCTT	0.368													-	37121153	-	-	37121134	7	5	35	1	0	1	0	1	0	0	0	0	15328	913	32	0	1552	0	STRN	2	37121134	Frame_Shift_Del	DEL	CTCGATCTTCACCGCTGTCA	TCGA-06-0174-01A-01D-1491-08	5525969	37121134	206078239	12	2176											
SLC9A4	389015	broad.mit.edu	37	chr2	103149061	103149061	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgagggcaaggcctctttgGttgaggttcggtcgaggtgg	19	6	1	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr2:103149061G>T	uc002tbz.3	+	12	2768	c.2311G>T	c.(2311-2313)GTT>TTT	p.V771F		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	771	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GGCCTCTTTGGTTGAGGTTCG	0.537													T	103149061	T	T	103149061	3	4	35	1	0	0	0	0	1	0	0	0	14716	1261	44	5	2357	5	SLC9A4	2	103149061	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	66027927	103149061	140050312	13	2177											
PKP4	8502	broad.mit.edu	37	chr2	159519424	159519424	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagacggtggagaactgcGtgtgcaccctgaggaacctg	14	10	1	3			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr2:159519424G>A	uc002tzv.2	+	14	2487	c.2227G>A	c.(2227-2229)GTG>ATG	p.V743M	PKP4_uc002tzt.1_Missense_Mutation_p.V595M|PKP4_uc002tzu.2_Missense_Mutation_p.V743M|PKP4_uc002tzw.2_Missense_Mutation_p.V743M|PKP4_uc002tzx.2_Missense_Mutation_p.V400M|PKP4_uc002tzy.1_Missense_Mutation_p.V401M|PKP4_uc002uaa.2_Missense_Mutation_p.V595M|uc002uab.1_Intron|PKP4_uc002uac.2_Translation_Start_Site	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	743	ARM 6.				cell adhesion	desmosome	protein binding	p.V743M(1)		ovary(5)|skin(2)	7						GGAGAACTGCGTGTGCACCCT	0.498										HNSCC(62;0.18)			A	159519424	A	A	159519424	3	1	35	1	0	0	0	0	1	0	0	0	11987	1145	40	1	2277	1	PKP4	2	159519424	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	56370363	159519424	83679949	14	2178											
ASNSD1	54529	broad.mit.edu	37	chr2	190531945	190531945	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcatagctgaagaaaagaccAtgccaactacctttaacaga	6	10	1	4			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr2:190531945A>G	uc002uqt.2	+	4	1521	c.1087A>G	c.(1087-1089)ATG>GTG	p.M363V		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	363	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			AGAAAAGACCATGCCAACTAC	0.378													G	190531945	G	G	190531945	3	3	35	1	0	0	0	0	1	0	0	0	1049	217	8	4	1089	4	ASNSD1	2	190531945	Missense_Mutation	SNP	A	TCGA-06-0174-01A-01D-1491-08	31012521	190531945	52667428	15	2179											
CNTN4	152330	broad.mit.edu	37	chr3	2861249	2861249	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggtgctactgtgtggcccGccaccccattctggaggtac	12	13	1	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr3:2861249G>A	uc003bpc.2	+	6	659	c.438G>A	c.(436-438)CCG>CCA	p.P146P	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Silent_p.P146P	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	146	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TGTGTGGCCCGCCACCCCATT	0.453													A	2861249	A	A	2861249	2	1	35	1	0	0	0	0	0	0	0	1	3643	1074	38	1		1	CNTN4	3	2861249	Silent	SNP	G	TCGA-06-0174-01A-01D-1491-08		2861249	195161181	16	2180											
TRIM71	131405	broad.mit.edu	37	chr3	32933041	32933041	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccgactgccagtcggcacGctttctgggctcggagggca	14	15	1	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr3:32933041G>A	uc003cff.2	+	4	2408	c.2345G>A	c.(2344-2346)CGC>CAC	p.R782H		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	782	NHL 5.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						CAGTCGGCACGCTTTCTGGGC	0.617													A	32933041	A	A	32933041	3	1	35	1	0	0	0	0	1	0	0	0	16541	1087	38	1	2359	1	TRIM71	3	32933041	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	30071792	32933041	165089389	17	2181											
CNGA1	1259	broad.mit.edu	37	chr4	47939480	47939480	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atacgtattttctagccaaaCggccaaattcaggatcatta	6	9	3	0	rs150374036	by1000genomes	TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr4:47939480C>T	uc003gxt.3	-	11	1297	c.1031G>A	c.(1030-1032)CGT>CAT	p.R344H	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.R413H	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	344	Cytoplasmic (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						TCTAGCCAAACGGCCAAATTC	0.413													T	47939480	T	T	47939480	3	4	35	1	0	0	0	0	1	0	0	0	3596	536	19	1	1045	1	CNGA1	4	47939480	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08		47939480	143214796	18	2182											
PDGFRA	5156	broad.mit.edu	37	chr4	55133834	55133834	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccacctcccaggatatcctgGctgaaaaacaatctgactct	6	14	2	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr4:55133834G>C	uc003han.3	+	7	1378	c.1047G>C	c.(1045-1047)TGG>TGC	p.W349C	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.W243C|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	349	Ig-like C2-type 4.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity	p.W349C(1)		soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GGATATCCTGGCTGAAAAACA	0.443			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			C	55133834	C	C	55133834	3	2	35	1	0	0	0	0	1	0	0	0	11661	1212	42	5	1069	5	PDGFRA	4	55133834	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	7194354	55133834	136020442	19	2183											
UFSP2	55325	broad.mit.edu	37	chr4	186334930	186334930	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtaagtatgtggatttctaaTgtaaccatctttgtatggct	9	5	2	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr4:186334930T>C	uc003ixo.2	-	7	898	c.781A>G	c.(781-783)ATT>GTT	p.I261V	UFSP2_uc003ixn.2_Missense_Mutation_p.I151V|UFSP2_uc003ixq.2_Missense_Mutation_p.I151V|UFSP2_uc003ixp.2_RNA	NM_018359	NP_060829	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	261						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		GGATTTCTAATGTAACCATCT	0.363													C	186334930	C	C	186334930	3	2	35	1	0	0	0	0	1	0	0	0	16935	1464	51	4	652	4	UFSP2	4	186334930	Missense_Mutation	SNP	T	TCGA-06-0174-01A-01D-1491-08	131201096	186334930	4819346	20	2184											
TUBB4Q	56604	broad.mit.edu	37	chr4	190904151	190904152	+	Frame_Shift_Ins	INS	-	G	G													aaggcccggtactgctggctINSgccccggctggtcagtgggg							TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr4:190904151_190904152insG	uc011clg.1	-	4	831_832	c.828_829insC	c.(826-831)GGCAGCfs	p.G276fs		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	277_278					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		TACTGCTGGCTGCCCCGGCTGG	0.614													G	190904152	G	G	190904151	7	5	35	1	0	1	1	0	0	0	0	0	16756	1580	55	0	475	0	TUBB4Q	4	190904151	Frame_Shift_Ins	INS	-	TCGA-06-0174-01A-01D-1491-08	4569221	190904151	250125	21	2185											
CCT5	22948	broad.mit.edu	37	chr5	10262653	10262653	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtgtcatccggaacctcatcCgcgataatcgtgtggtgtat	11	10	2	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr5:10262653C>A	uc003jeq.2	+	9	1411	c.1240C>A	c.(1240-1242)CGC>AGC	p.R414S	CCT5_uc003jer.2_Missense_Mutation_p.R414S|CCT5_uc010its.2_Missense_Mutation_p.R414S|CCT5_uc011cmr.1_Missense_Mutation_p.R359S|CCT5_uc011cms.1_Missense_Mutation_p.R376S|CCT5_uc011cmt.1_Missense_Mutation_p.R321S	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	414					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						GAACCTCATCCGCGATAATCG	0.493													A	10262653	A	A	10262653	3	1	35	1	0	0	0	0	1	0	0	0	2956	652	23	5	1274	5	CCT5	5	10262653	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08		10262653	170652607	22	2186											
SNX18	112574	broad.mit.edu	37	chr5	53815264	53815264	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggcctgaaccaggctatcgcCttcaccggagatgcctatga	11	13	1	3			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr5:53815264C>G	uc003jpj.3	+	1	1672	c.1482C>G	c.(1480-1482)GCC>GCG	p.A494A	SNX18_uc011cqg.1_Silent_p.A494A|SNX18_uc003jpi.3_Silent_p.A494A	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	494	BAR.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				AGGCTATCGCCTTCACCGGAG	0.617													G	53815264	G	G	53815264	2	3	35	1	0	0	0	0	0	0	0	1	14889	668	24	5		5	SNX18	5	53815264	Silent	SNP	C	TCGA-06-0174-01A-01D-1491-08	43552611	53815264	127099996	23	2187											
PCDHA11	56138	broad.mit.edu	37	chr5	140250296	140250296	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacagttccaggtgagcgcGcgcgatgcgggcgtgccgcc	16	14	0	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr5:140250296G>A	uc003lia.2	+	1	2466	c.1608G>A	c.(1606-1608)GCG>GCA	p.A536A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.A536A	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	536	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGAGCGCGCGCGATGCGG	0.667													A	140250296	A	A	140250296	2	1	35	1	0	0	0	0	0	0	0	1	11521	1074	38	1		1	PCDHA11	5	140250296	Silent	SNP	G	TCGA-06-0174-01A-01D-1491-08	86435032	140250296	40664964	24	2188											
PCDHGB5	56101	broad.mit.edu	37	chr5	140779096	140779096	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accctcctggggcctccatcGcgcaagtctgcgcctcggac	11	18	1	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr5:140779096G>A	uc003lkf.1	+	1	1402	c.1402G>A	c.(1402-1404)GCG>ACG	p.A468T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.A468T	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	468	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCTCCATCGCGCAAGTCTG	0.567													A	140779096	A	A	140779096	3	1	35	1	0	0	0	0	1	0	0	0	11566	1087	38	1	1404	1	PCDHGB5	5	140779096	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	528800	140779096	40136164	25	2189											
RANBP17	64901	broad.mit.edu	37	chr5	170351426	170351426	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagttggagcagttgtgcaCggtcagcagatgtgaatatg	15	6	1	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr5:170351426C>T	uc003mba.2	+	12	1356	c.1340C>T	c.(1339-1341)ACG>ATG	p.T447M	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	447					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGTTGTGCACGGTCAGCAGA	0.413			T	TRD@	ALL								T	170351426	T	T	170351426	3	4	35	1	0	0	0	0	1	0	0	0	13027	536	19	1	1386	1	RANBP17	5	170351426	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	29572330	170351426	10563834	26	2190											
PKHD1	5314	broad.mit.edu	37	chr6	51890717	51890717	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgactactggtgttgctgcCgcttcatacatgaaggtgaa	12	8	1	3			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr6:51890717C>T	uc003pah.1	-	32	4167	c.3891G>A	c.(3889-3891)GCG>GCA	p.A1297A	PKHD1_uc003pai.2_Silent_p.A1297A	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1297	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTGTTGCTGCCGCTTCATACA	0.547													T	51890717	T	T	51890717	2	4	35	1	0	0	0	0	0	0	0	1	11971	639	23	2		2	PKHD1	6	51890717	Silent	SNP	C	TCGA-06-0174-01A-01D-1491-08		51890717	119224350	27	2191											
ENPP1	5167	broad.mit.edu	37	chr6	132203516	132203516	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tacggaagacttctccaactGtctgtaccaggactttagaa	8	10	2	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr6:132203516G>C	uc011ecf.1	+	21	2152	c.2132G>C	c.(2131-2133)TGT>TCT	p.C711S		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	711	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTCTCCAACTGTCTGTACCAG	0.383													C	132203516	C	C	132203516	3	2	35	1	0	0	0	0	1	0	0	0	5129	1377	48	5	2214	5	ENPP1	6	132203516	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	80312799	132203516	38911551	28	2192											
BBS9	27241	broad.mit.edu	37	chr7	33397475	33397475	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttttattttaggcattccgCgagttatccaatgtaaattt	6	7	0	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:33397475C>T	uc003tdn.1	+	16	2074	c.1561C>T	c.(1561-1563)CGA>TGA	p.R521*	BBS9_uc003tdo.1_Nonsense_Mutation_p.R486*|BBS9_uc003tdp.1_Nonsense_Mutation_p.R516*|BBS9_uc003tdq.1_Nonsense_Mutation_p.R481*|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Nonsense_Mutation_p.R45*|BBS9_uc003tds.1_5'UTR|BBS9_uc011kao.1_Nonsense_Mutation_p.R399*	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	521					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			AGGCATTCCGCGAGTTATCCA	0.323									Bardet-Biedl_syndrome				T	33397475	T	T	33397475	4	4	35	1	0	0	0	0	0	1	0	0	1342	760	27	1	1619	1	BBS9	7	33397475	Nonsense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08		33397475	125741188	29	2193											
AOAH	313	broad.mit.edu	37	chr7	36571797	36571797	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgttggaagacatccagcCgtggcaggggctgacctgag	15	10	0	3			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:36571797C>T	uc003tfh.3	-	18	1782	c.1381G>A	c.(1381-1383)GGC>AGC	p.G461S	AOAH_uc010kxf.2_Missense_Mutation_p.G461S|AOAH_uc011kba.1_Missense_Mutation_p.G429S	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	461					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						GACATCCAGCCGTGGCAGGGG	0.512													T	36571797	T	T	36571797	3	4	35	1	0	0	0	0	1	0	0	0	726	652	23	2	703	2	AOAH	7	36571797	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	3174322	36571797	122566866	30	2194											
EPDR1	54749	broad.mit.edu	37	chr7	37989842	37989842	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatacagtcaaggattgctaTcctgtccaggaaacctttac	7	10	1	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:37989842T>C	uc003tfp.2	+	3	898	c.879T>C	c.(877-879)TAT>TAC	p.Y293Y	EPDR1_uc003tfq.2_3'UTR|EPDR1_uc010kxh.2_Silent_p.Y112Y	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	173					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						AGGATTGCTATCCTGTCCAGG	0.388													C	37989842	C	C	37989842	2	2	35	1	0	0	0	0	0	0	0	1	5163	1442	50	4		4	EPDR1	7	37989842	Silent	SNP	T	TCGA-06-0174-01A-01D-1491-08	1418045	37989842	121148821	31	2195											
VSTM2A	222008	broad.mit.edu	37	chr7	54612435	54612435	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatccaatggtggttcctgcGggggccggaggacctggatc	17	10	0	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:54612435G>A	uc010kzf.2	+	2	605	c.200G>A	c.(199-201)CGG>CAG	p.R67Q	VSTM2A_uc010kze.2_Missense_Mutation_p.R67Q|VSTM2A_uc003tqc.3_Missense_Mutation_p.R67Q	NM_182546	NP_872352	Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2	67	Ig-like V-type.					extracellular region					0			STAD - Stomach adenocarcinoma(5;0.0525)			TGGTTCCTGCGGGGGCCGGAG	0.716													A	54612435	A	A	54612435	3	1	35	1	0	0	0	0	1	0	0	0	17226	1116	39	2	206	2	VSTM2A	7	54612435	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	16622593	54612435	104526228	32	2196											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	35	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	620608	55233043	103905620	33	2197											
EGFR	1956	broad.mit.edu	37	chr7	55233091	55233091	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggaagtacgcagacgccgGccatgtgtgccacctgtgcc	13	14	0	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:55233091G>A	uc003tqk.2	+	15	2087	c.1841G>A	c.(1840-1842)GGC>GAC	p.G614D	EGFR_uc003tqi.2_Missense_Mutation_p.G614D|EGFR_uc003tqj.2_Missense_Mutation_p.G614D|EGFR_uc010kzg.1_Missense_Mutation_p.G569D|EGFR_uc011kco.1_Missense_Mutation_p.G561D|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	614	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GCAGACGCCGGCCATGTGTGC	0.537		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55233091	A	A	55233091	3	1	35	1	0	0	0	0	1	0	0	0	4967	1203	42	3	1910	3	EGFR	7	55233091	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	48	55233091	103905572	34	2198											
KIAA1324L	222223	broad.mit.edu	37	chr7	86548556	86548556	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttaaatcctgggatatgcaaGtttaagatcaggtaatcatt	8	5	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:86548556G>T	uc011kha.1	-	11	1655	c.1470C>A	c.(1468-1470)AAC>AAA	p.N490K	KIAA1324L_uc003uif.1_Missense_Mutation_p.N250K|KIAA1324L_uc011kgz.1_Missense_Mutation_p.N376K|KIAA1324L_uc003uie.2_Missense_Mutation_p.N323K	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	490	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					GGATATGCAAGTTTAAGATCA	0.373													T	86548556	T	T	86548556	3	4	35	1	0	0	0	0	1	0	0	0	8224	1020	36	5	1667	5	KIAA1324L	7	86548556	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	31315465	86548556	72590107	35	2199											
FAM200A	221786	broad.mit.edu	37	chr7	99145995	99145995	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atctcctgggtaccccctggAgacaaatctgtagtatccct	8	13	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:99145995A>C	uc003ura.2	-	2	375	c.36T>G	c.(34-36)TCT>TCG	p.S12S	FAM200A_uc003urb.2_Silent_p.S12S	NM_145111	NP_659802	Q8TCP9	F200A_HUMAN	hypothetical protein LOC221786	12	Extracellular (Potential).					integral to membrane	nucleic acid binding				0						TACCCCCTGGAGACAAATCTG	0.408													C	99145995	C	C	99145995	2	2	35	1	0	0	0	0	0	0	0	1	5536	291	11	5		5	FAM200A	7	99145995	Silent	SNP	A	TCGA-06-0174-01A-01D-1491-08	12597439	99145995	59992668	36	2200											
FBXO24	26261	broad.mit.edu	37	chr7	100197689	100197689	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcccatcaccctgtggtgCggcctcaaccactccctggt	10	18	2	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:100197689C>T	uc003uvm.1	+	9	1535	c.1242C>T	c.(1240-1242)TGC>TGT	p.C414C	FBXO24_uc003uvn.1_Intron|uc011kjy.1_RNA|FBXO24_uc011kjz.1_Silent_p.C452C|FBXO24_uc011kka.1_Silent_p.C402C|PCOLCE_uc011kkb.1_5'Flank|PCOLCE_uc003uvo.2_5'Flank|PCOLCE_uc010lhb.1_5'Flank	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	414	RCC1.					ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCCTGTGGTGCGGCCTCAACC	0.692													T	100197689	T	T	100197689	2	4	35	1	0	0	0	0	0	0	0	1	5735	776	27	1		1	FBXO24	7	100197689	Silent	SNP	C	TCGA-06-0174-01A-01D-1491-08	1051694	100197689	58940974	37	2201											
SVOPL	136306	broad.mit.edu	37	chr7	138314843	138314843	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	taaatatttagcatccaataGgtctgcaaatcttcctcttt	4	9	3	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:138314843G>T	uc011kqh.1	-	9	814	c.814C>A	c.(814-816)CTA>ATA	p.L272I	SVOPL_uc003vue.2_Missense_Mutation_p.L120I	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	272						integral to membrane	transmembrane transporter activity				0						GCATCCAATAGGTCTGCAAAT	0.393													T	138314843	T	T	138314843	3	4	35	1	0	0	0	0	1	0	0	0	15421	991	35	5	692	5	SVOPL	7	138314843	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	38117154	138314843	20823820	38	2202											
NOS3	4846	broad.mit.edu	37	chr7	150699051	150699051	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccggaaggcttttgatcccCgggtagggctgagcccaggg	16	11	0	2	rs142781987		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr7:150699051C>T	uc003wif.2	+	13	1941	c.1645C>T	c.(1645-1647)CGG>TGG	p.R549W	NOS3_uc011kuy.1_Missense_Mutation_p.R343W|NOS3_uc011kuz.1_Missense_Mutation_p.R549W|NOS3_uc011kva.1_Missense_Mutation_p.R549W|NOS3_uc011kvb.1_Missense_Mutation_p.R549W	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	549	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	TTTTGATCCCCGGGTAGGGCT	0.612													T	150699051	T	T	150699051	3	4	35	1	0	0	0	0	1	0	0	0	10544	643	23	2	1691	2	NOS3	7	150699051	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	12384208	150699051	8439612	39	2203											
NEIL2	252969	broad.mit.edu	37	chr8	11643604	11643604	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtacagcctggctgcaggGcaagttccaaggcagaccgc	13	13	0	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr8:11643604G>A	uc003wug.2	+	5	1496	c.821G>A	c.(820-822)GGC>GAC	p.G274D	NEIL2_uc003wue.2_Missense_Mutation_p.G274D|NEIL2_uc003wuf.2_Missense_Mutation_p.G213D|NEIL2_uc011kxd.1_Missense_Mutation_p.G158D	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	274					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		TGGCTGCAGGGCAAGTTCCAA	0.607								BER_DNA_glycosylases					A	11643604	A	A	11643604	3	1	35	1	0	0	0	0	1	0	0	0	10319	1203	42	3	840	3	NEIL2	8	11643604	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08		11643604	134720418	40	2204											
DOCK5	80005	broad.mit.edu	37	chr8	25191663	25191663	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agttccagcattttaatcctGtacttgaaacctacatttac	4	10	0	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr8:25191663G>A	uc003xeg.2	+	21	2280	c.2143G>A	c.(2143-2145)GTA>ATA	p.V715I	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.V429I|DOCK5_uc003xei.2_Missense_Mutation_p.V285I|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	715						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TTTTAATCCTGTACTTGAAAC	0.368													A	25191663	A	A	25191663	3	1	35	1	0	0	0	0	1	0	0	0	4690	1377	48	3	2225	3	DOCK5	8	25191663	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	13548059	25191663	121172359	41	2205											
TEX15	56154	broad.mit.edu	37	chr8	30700748	30700748	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acaaagtatcatatatcttcTgcaacttagaaaaggcacat	5	8	3	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr8:30700748T>C	uc003xil.2	-	1	5786	c.5786A>G	c.(5785-5787)CAG>CGG	p.Q1929R		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1929										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATATATCTTCTGCAACTTAGA	0.358													C	30700748	C	C	30700748	3	2	35	1	0	0	0	0	1	0	0	0	15776	1580	55	4	2599	4	TEX15	8	30700748	Missense_Mutation	SNP	T	TCGA-06-0174-01A-01D-1491-08	5509085	30700748	115663274	42	2206											
ST18	9705	broad.mit.edu	37	chr8	53025895	53025895	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaattctgctcactgatagGtccctaaatggagacaaaac	7	9	2	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr8:53025895G>A	uc003xqz.2	-	21	3163	c.3007C>T	c.(3007-3009)CCT>TCT	p.P1003S	ST18_uc011ldq.1_Missense_Mutation_p.P650S|ST18_uc011ldr.1_Missense_Mutation_p.P968S|ST18_uc011lds.1_Missense_Mutation_p.P908S|ST18_uc003xra.2_Missense_Mutation_p.P1003S	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	1003						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCACTGATAGGTCCCTAAATG	0.463													A	53025895	A	A	53025895	3	1	35	1	0	0	0	0	1	0	0	0	15211	1261	44	3	140	3	ST18	8	53025895	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	22325147	53025895	93338127	43	2207											
CPA6	57094	broad.mit.edu	37	chr8	68334862	68334862	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tatccagtgtcacgtagttcGaaagcaaatgcataaggtat	9	7	1	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr8:68334862G>A	uc003xxq.3	-	11	1447	c.1191C>T	c.(1189-1191)TTC>TTT	p.F397F	CPA6_uc003xxr.3_Silent_p.F153F	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	397					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			CACGTAGTTCGAAAGCAAATG	0.383													A	68334862	A	A	68334862	2	1	35	1	0	0	0	0	0	0	0	1	3794	1049	37	2		2	CPA6	8	68334862	Silent	SNP	G	TCGA-06-0174-01A-01D-1491-08	15308967	68334862	78029160	44	2208											
JPH1	56704	broad.mit.edu	37	chr8	75171694	75171694	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actcctggcgagcggccagcGcggcctggtcggcggcatcg	17	15	0	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr8:75171694G>A	uc003yae.2	-	3	1224	c.1184C>T	c.(1183-1185)GCG>GTG	p.A395V	JPH1_uc003yaf.2_Missense_Mutation_p.A395V|JPH1_uc003yag.1_Missense_Mutation_p.A259V	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	395	Ala-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			AGCGGCCAGCGCGGCCTGGTC	0.597													A	75171694	A	A	75171694	3	1	35	1	0	0	0	0	1	0	0	0	7960	1087	38	1	813	1	JPH1	8	75171694	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	6836832	75171694	71192328	45	2209											
RAD54B	25788	broad.mit.edu	37	chr8	95412584	95412584	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttctttattactggcttgCctccatagggtccctgacac	7	13	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr8:95412584C>T	uc003ygk.2	-	7	1150	c.1052G>A	c.(1051-1053)GGC>GAC	p.G351D	RAD54B_uc010may.1_Missense_Mutation_p.G158D|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			TACTGGCTTGCCTCCATAGGG	0.433								Direct_reversal_of_damage|Homologous_recombination					T	95412584	T	T	95412584	3	4	35	1	0	0	0	0	1	0	0	0	12992	739	26	3	1716	3	RAD54B	8	95412584	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	20240890	95412584	50951438	46	2210											
TRPS1	7227	broad.mit.edu	37	chr8	116616647	116616647	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaagtccttctttttagcccCactcgagctcttgtctgtct	7	13	4	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr8:116616647C>G	uc003ynz.2	-	3	1969	c.1510G>C	c.(1510-1512)GGG>CGG	p.G504R	TRPS1_uc011lhy.1_Missense_Mutation_p.G508R|TRPS1_uc003yny.2_Missense_Mutation_p.G517R|TRPS1_uc010mcy.2_Missense_Mutation_p.G504R	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	504					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTTTTAGCCCCACTCGAGCTC	0.438									Langer-Giedion_syndrome				G	116616647	G	G	116616647	3	3	35	1	0	0	0	0	1	0	0	0	16590	594	21	5	2351	5	TRPS1	8	116616647	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	21204063	116616647	29747375	47	2211											
DMRTA1	63951	broad.mit.edu	37	chr9	22447335	22447336	+	Frame_Shift_Ins	INS	-	A	A													aggcgcggtgggctgcggctINSacccgcggacgcccaagtgc					rs111465355		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr9:22447335_22447336insA	uc003zpp.1	+	1	496_497	c.271_272insA	c.(271-273)TACfs	p.Y91fs		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	91					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		GGGCTGCGGCTACCCGCGGACG	0.624													A	22447336	A	A	22447335	7	5	35	1	0	1	1	0	0	0	0	0	4588	1522	53	0	273	0	DMRTA1	9	22447335	Frame_Shift_Ins	INS	-	TCGA-06-0174-01A-01D-1491-08		22447335	118766096	48	2212											
VAV2	7410	broad.mit.edu	37	chr9	136653541	136653541	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaacagcagctcgatgatctCcttgagctcgtagctgtagc	11	11	1	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr9:136653541C>T	uc004ces.2	-	15	1388	c.1342G>A	c.(1342-1344)GAG>AAG	p.E448K	VAV2_uc004cer.2_Missense_Mutation_p.E443K|VAV2_uc004cet.1_5'UTR	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	448	PH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		TCGATGATCTCCTTGAGCTCG	0.592													T	136653541	T	T	136653541	3	4	35	1	0	0	0	0	1	0	0	0	17129	864	30	3	1358	3	VAV2	9	136653541	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	114206206	136653541	4559890	49	2213											
KIAA1217	56243	broad.mit.edu	37	chr10	24790356	24790356	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcagtgctctggagtccaCggtgcctcccagccagcctc	11	17	2	0	rs141937477		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr10:24790356C>T	uc001iru.3	+	9	2286	c.1883C>T	c.(1882-1884)ACG>ATG	p.T628M	KIAA1217_uc001irs.2_Missense_Mutation_p.T548M|KIAA1217_uc001irt.3_Missense_Mutation_p.T593M|KIAA1217_uc010qcy.1_Missense_Mutation_p.T593M|KIAA1217_uc010qcz.1_Missense_Mutation_p.T593M|KIAA1217_uc001irv.1_Missense_Mutation_p.T443M|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Missense_Mutation_p.T311M|KIAA1217_uc001irz.2_Missense_Mutation_p.T311M|KIAA1217_uc001irx.2_Missense_Mutation_p.T311M|KIAA1217_uc001iry.2_Missense_Mutation_p.T311M	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	628					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CTGGAGTCCACGGTGCCTCCC	0.582													T	24790356	T	T	24790356	3	4	35	1	0	0	0	0	1	0	0	0	8216	536	19	1	1917	1	KIAA1217	10	24790356	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08		24790356	110744391	50	2214											
ARMC4	55130	broad.mit.edu	37	chr10	28229528	28229528	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcaatgtccccaccactggAattagcatgttttcatgaga	8	10	1	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr10:28229528A>C	uc009xky.2	-	13	2048	c.1950T>G	c.(1948-1950)ATT>ATG	p.I650M	ARMC4_uc010qds.1_Missense_Mutation_p.I175M|ARMC4_uc010qdt.1_Missense_Mutation_p.I342M|ARMC4_uc001itz.2_Missense_Mutation_p.I650M|ARMC4_uc010qdu.1_Missense_Mutation_p.I342M	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	650	ARM 3.						binding			ovary(4)|skin(2)	6						CCACCACTGGAATTAGCATGT	0.473													C	28229528	C	C	28229528	3	2	35	1	0	0	0	0	1	0	0	0	953	242	9	5	1216	5	ARMC4	10	28229528	Missense_Mutation	SNP	A	TCGA-06-0174-01A-01D-1491-08	3439172	28229528	107305219	51	2215											
OR13A1	79290	broad.mit.edu	37	chr10	45799324	45799324	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggccacagaaatccaagcGcagcatcagccccgtgtgga	13	13	1	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr10:45799324G>A	uc001jcc.1	-	4	856	c.547C>T	c.(547-549)CGC>TGC	p.R183C	OR13A1_uc001jcd.1_Missense_Mutation_p.R179C	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAATCCAAGCGCAGCATCAGC	0.587													A	45799324	A	A	45799324	3	1	35	1	0	0	0	0	1	0	0	0	10933	1087	38	1	443	1	OR13A1	10	45799324	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	17569796	45799324	89735423	52	2216											
DNTT	1791	broad.mit.edu	37	chr10	98079146	98079146	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caactgtaaccagatattcaCggtaacgggactttacatca	7	10	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr10:98079146C>T	uc001kmf.2	+	3	676	c.506C>T	c.(505-507)ACG>ATG	p.T169M	DNTT_uc001kmg.2_Missense_Mutation_p.T169M	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	169	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		CAGATATTCACGGTAACGGGA	0.448													T	98079146	T	T	98079146	3	4	35	1	0	0	0	0	1	0	0	0	4680	550	19	1	516	1	DNTT	10	98079146	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	52279822	98079146	37455601	53	2217											
PAX2	5076	broad.mit.edu	37	chr10	102510548	102510548	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaagattgctgaatacaaaCgacagaacccgactatgttc	7	10	0	3			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr10:102510548C>T	uc001krk.3	+	3	860	c.310C>T	c.(310-312)CGA>TGA	p.R104*	PAX2_uc001krl.3_Nonsense_Mutation_p.R104*|PAX2_uc001krm.3_Nonsense_Mutation_p.R104*|PAX2_uc001kro.3_Nonsense_Mutation_p.R104*|PAX2_uc001krn.3_Nonsense_Mutation_p.R104*|PAX2_uc010qps.1_Nonsense_Mutation_p.R103*|PAX2_uc001krp.1_Nonsense_Mutation_p.R108*	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	104	Paired.				anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		TGAATACAAACGACAGAACCC	0.572													T	102510548	T	T	102510548	4	4	35	1	0	0	0	0	0	1	0	0	11479	528	19	1	320	1	PAX2	10	102510548	Nonsense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	4431402	102510548	33024199	54	2218											
OR4C6	219432	broad.mit.edu	37	chr11	55433358	55433358	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caaagccctctctacctgcaGctcccacctcacggtggttg	8	17	2	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr11:55433358G>T	uc001nht.3	+	3	981	c.716G>T	c.(715-717)AGC>ATC	p.S239I	OR4C6_uc010rik.1_Missense_Mutation_p.S239I	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	239	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TCTACCTGCAGCTCCCACCTC	0.502													T	55433358	T	T	55433358	3	4	35	1	0	0	0	0	1	0	0	0	11052	971	34	5	718	5	OR4C6	11	55433358	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08		55433358	79573158	55	2219											
ASAM	79827	broad.mit.edu	37	chr11	122944226	122944226	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctggctggggatcatgctggGtgtggtttctgctttggtca	16	7	3	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr11:122944226G>T	uc001pyt.2	-	7	1437	c.1078C>A	c.(1078-1080)CCC>ACC	p.P360T		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	360	Cytoplasmic (Potential).					integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		ATCATGCTGGGTGTGGTTTCT	0.537													T	122944226	T	T	122944226	3	4	35	1	0	0	0	0	1	0	0	0	1009	1261	44	5	47	5	ASAM	11	122944226	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	67510868	122944226	12062290	56	2220											
CD4	920	broad.mit.edu	37	chr12	6923329	6923329	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccatccaagctgaatgatcGcgctgactcaagaagaagcc	9	12	1	5			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:6923329G>A	uc001qqv.1	+	4	481	c.236G>A	c.(235-237)CGC>CAC	p.R79H	CD4_uc009zez.1_Missense_Mutation_p.R24H|CD4_uc009zfa.1_RNA|CD4_uc009zfb.1_RNA|CD4_uc010sfj.1_5'UTR|CD4_uc009zfc.1_5'UTR|CD4_uc010sfk.1_5'UTR|CD4_uc010sfl.1_5'UTR|CD4_uc010sfm.1_5'UTR	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	79	Extracellular (Potential).|Ig-like V-type.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				CTGAATGATCGCGCTGACTCA	0.522													A	6923329	A	A	6923329	3	1	35	1	0	0	0	0	1	0	0	0	3014	1087	38	1	246	1	CD4	12	6923329	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08		6923329	126928566	57	2221											
PHC1	1911	broad.mit.edu	37	chr12	9087006	9087006	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaacccccacaggccatcGtgaagccccagattctcacc	6	18	1	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:9087006G>A	uc001qvd.2	+	10	2341	c.2185G>A	c.(2185-2187)GTG>ATG	p.V729M	PHC1_uc001qve.2_Missense_Mutation_p.V729M	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	729					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ACAGGCCATCGTGAAGCCCCA	0.542													A	9087006	A	A	9087006	3	1	35	1	0	0	0	0	1	0	0	0	11816	1145	40	1	2219	1	PHC1	12	9087006	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	2163677	9087006	124764889	58	2222											
BICD1	636	broad.mit.edu	37	chr12	32491868	32491868	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccatgagtgaattcatccaaGggcaccggctcagcaaggaa	11	11	2	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:32491868G>C	uc001rku.2	+	8	2800	c.2719G>C	c.(2719-2721)GGG>CGG	p.G907R	BICD1_uc001rkv.2_Intron|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	907					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			ATTCATCCAAGGGCACCGGCT	0.463													C	32491868	C	C	32491868	3	2	35	1	0	0	0	0	1	0	0	0	1428	1000	35	5	2749	5	BICD1	12	32491868	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	23404862	32491868	101360027	59	2223											
BCDIN3D	144233	broad.mit.edu	37	chr12	50232500	50232500	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggccaggaactcccataggCcatggtctccatgattcaga	11	12	2	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:50232500C>T	uc001rvh.2	-	2	575	c.533G>A	c.(532-534)GGC>GAC	p.G178D	LOC100286844_uc010smm.1_Intron|LOC100286844_uc001rvg.2_RNA|LOC100286844_uc010smn.1_RNA	NM_181708	NP_859059	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	178	Bin3-type SAM.						methyltransferase activity			ovary(1)	1						CTCCCATAGGCCATGGTCTCC	0.512											OREG0021805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	50232500	T	T	50232500	3	4	35	1	0	0	0	0	1	0	0	0	1357	739	26	3	349	3	BCDIN3D	12	50232500	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	17740632	50232500	83619395	60	2224											
ATF7	11016	broad.mit.edu	37	chr12	53928392	53928392	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagaggcagggagccaggacGtacaatggtgggtgtggggg	22	5	0	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:53928392G>A	uc001sdy.2	-	5	508	c.487C>T	c.(487-489)CGT>TGT	p.R163C	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Missense_Mutation_p.R152C|ATF7_uc010sol.1_Missense_Mutation_p.R131C	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	163	Transactivation domain.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GAGCCAGGACGTACAATGGTG	0.512													A	53928392	A	A	53928392	3	1	35	1	0	0	0	0	1	0	0	0	1086	1145	40	1	1025	1	ATF7	12	53928392	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	3695892	53928392	79923503	61	2225											
AVIL	10677	broad.mit.edu	37	chr12	58207190	58207190	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatgtcctgggataggagaCtggccactctccgggtctgg	16	10	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:58207190C>T	uc001sqj.1	-	3	187	c.158G>A	c.(157-159)AGT>AAT	p.S53N	AVIL_uc009zqe.1_Missense_Mutation_p.S46N|AVIL_uc001sql.3_Missense_Mutation_p.S30N	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	53	Gelsolin-like 1.|Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					GGATAGGAGACTGGCCACTCT	0.582													T	58207190	T	T	58207190	3	4	35	1	0	0	0	0	1	0	0	0	1227	565	20	3	2369	3	AVIL	12	58207190	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	4278798	58207190	75644705	62	2226											
CPSF6	11052	broad.mit.edu	37	chr12	69653833	69653833	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttccctcacaggtgattatgGgagtgctattgagacactgg	12	8	1	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:69653833G>T	uc001sut.3	+	8	1435	c.1325G>T	c.(1324-1326)GGG>GTG	p.G442V	CPSF6_uc001suu.3_Missense_Mutation_p.G479V|CPSF6_uc010stk.1_Missense_Mutation_p.G73V	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	442					mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			GGTGATTATGGGAGTGCTATT	0.328													T	69653833	T	T	69653833	3	4	35	1	0	0	0	0	1	0	0	0	3829	1232	43	5	1355	5	CPSF6	12	69653833	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	11446643	69653833	64198062	63	2227											
NOS1	4842	broad.mit.edu	37	chr12	117718572	117718572	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtcccccagggtggagccGtcaggctgcttgtagccagc	16	13	1	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:117718572G>A	uc001twm.1	-	8	2168	c.1482C>T	c.(1480-1482)GAC>GAT	p.D494D		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	494					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGGTGGAGCCGTCAGGCTGCT	0.617													A	117718572	A	A	117718572	2	1	35	1	0	0	0	0	0	0	0	1	10541	1136	40	1		1	NOS1	12	117718572	Silent	SNP	G	TCGA-06-0174-01A-01D-1491-08	48064739	117718572	16133323	64	2228											
TMEM132B	114795	broad.mit.edu	37	chr12	126004117	126004117	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tccatgagtgagctggtcgtCtccgagatcttcgtcagcca	11	12	3	3			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:126004117C>T	uc001uhe.1	+	4	1232	c.1224C>T	c.(1222-1224)GTC>GTT	p.V408V		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	408	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGCTGGTCGTCTCCGAGATCT	0.532													T	126004117	T	T	126004117	2	4	35	1	0	0	0	0	0	0	0	1	16043	900	32	3		3	TMEM132B	12	126004117	Silent	SNP	C	TCGA-06-0174-01A-01D-1491-08	8285545	126004117	7847778	65	2229											
GLT1D1	144423	broad.mit.edu	37	chr12	129360558	129360558	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcatcttggctgagaactgCgaggctgccctggctcttca	11	13	4	1	rs144231014		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr12:129360558C>T	uc010tbh.1	+	2	144	c.135C>T	c.(133-135)TGC>TGT	p.C45C	GLT1D1_uc001uhx.1_Silent_p.C56C|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	56					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		CTGAGAACTGCGAGGCTGCCC	0.483													T	129360558	T	T	129360558	2	4	35	1	0	0	0	0	0	0	0	1	6465	776	27	1		1	GLT1D1	12	129360558	Silent	SNP	C	TCGA-06-0174-01A-01D-1491-08	3356441	129360558	4491337	66	2230											
ZMYM5	9205	broad.mit.edu	37	chr13	20409775	20409775	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caatctgtacttattaaagcAatggttactgcacagtttat	6	7	1	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr13:20409775A>G	uc010tcn.1	-	7	1358	c.1093T>C	c.(1093-1095)TGC>CGC	p.C365R	ZMYM5_uc001umm.1_Missense_Mutation_p.C189R	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	365	MYM-type 3.					nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TTATTAAAGCAATGGTTACTG	0.363													G	20409775	G	G	20409775	3	3	35	1	0	0	0	0	1	0	0	0	17700	130	5	4	924	4	ZMYM5	13	20409775	Missense_Mutation	SNP	A	TCGA-06-0174-01A-01D-1491-08		20409775	94760103	67	2231											
NBEA	26960	broad.mit.edu	37	chr13	35730325	35730325	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatgataaaacttttcagtaAcagccgtgaaaatagaaggt	8	5	1	3			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr13:35730325A>C	uc001uvb.2	+	21	2839	c.2633A>C	c.(2632-2634)AAC>ACC	p.N878T		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	878						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTTTTCAGTAACAGCCGTGAA	0.313													C	35730325	C	C	35730325	3	2	35	1	0	0	0	0	1	0	0	0	10187	43	2	5	2711	5	NBEA	13	35730325	Missense_Mutation	SNP	A	TCGA-06-0174-01A-01D-1491-08	15320550	35730325	79439553	68	2232											
SCEL	8796	broad.mit.edu	37	chr13	78176839	78176839	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaatgccaggatgaataaaaCgagcagaaggtgagaactga	13	5	0	4	rs144213801		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr13:78176839C>T	uc001vki.2	+	17	1198	c.1028C>T	c.(1027-1029)ACG>ATG	p.T343M	SCEL_uc001vkj.2_Missense_Mutation_p.T323M|SCEL_uc010thx.1_Missense_Mutation_p.T321M	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	343	16 X approximate tandem repeats.|5.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		ATGAATAAAACGAGCAGAAGG	0.348													T	78176839	T	T	78176839	3	4	35	1	0	0	0	0	1	0	0	0	13888	536	19	1	1090	1	SCEL	13	78176839	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	42446514	78176839	36993039	69	2233											
HECTD1	25831	broad.mit.edu	37	chr14	31582555	31582555	+	Frame_Shift_Del	DEL	C	-	-													cagaagctgaaggacatcttCtactccacaagagttctgtc							TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr14:31582555delC	uc001wrc.1	-	33	6481	c.5992delG	c.(5992-5994)GAAfs	p.E1998fs	HECTD1_uc001wra.1_Frame_Shift_Del_p.E124fs|HECTD1_uc001wrb.1_Frame_Shift_Del_p.E124fs|HECTD1_uc001wrd.1_Frame_Shift_Del_p.E1466fs	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1998					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		AGGACATCTTCTACTCCACAA	0.403													-	31582555	-	-	31582555	7	5	35	1	0	1	0	1	0	0	0	0	7039	922	32	0	1884	0	HECTD1	14	31582555	Frame_Shift_Del	DEL	C	TCGA-06-0174-01A-01D-1491-08		31582555	75766985	70	2234											
RPL10L	140801	broad.mit.edu	37	chr14	47120929	47120929	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accggtaacagcgagctggaCggcgccccatggcgacacag	14	14	0	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr14:47120929C>T	uc001wwg.2	-	1	100	c.11G>A	c.(10-12)CGT>CAT	p.R4H		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	4					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						GCGAGCTGGACGGCGCCCCAT	0.557													T	47120929	T	T	47120929	3	4	35	1	0	0	0	0	1	0	0	0	13556	536	19	1	637	1	RPL10L	14	47120929	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	15538374	47120929	60228611	71	2235											
ACYP1	97	broad.mit.edu	37	chr14	75520272	75520272	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccattcctgcatatgacgcaCcttggagatgggaccttgca	10	12	0	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr14:75520272C>T	uc001xrg.2	-	3	263	c.175G>A	c.(175-177)GTG>ATG	p.V59M	MLH3_uc001xrd.1_5'Flank|MLH3_uc001xre.1_5'Flank|ACYP1_uc001xrf.2_3'UTR	NM_001107	NP_001098	P07311	ACYP1_HUMAN	acylphosphatase 1 isoform a	59	Acylphosphatase-like.				phosphate metabolic process		acylphosphatase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00646)		ATATGACGCACCTTGGAGATG	0.478													T	75520272	T	T	75520272	3	4	35	1	0	0	0	0	1	0	0	0	228	507	18	3	128	3	ACYP1	14	75520272	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	28399343	75520272	31829268	72	2236											
AHNAK2	113146	broad.mit.edu	37	chr14	105412495	105412495	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacctccacgtcgggggccGtcacgtccgtcttcgggcct	12	17	2	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr14:105412495G>A	uc010axc.1	-	7	9413	c.9293C>T	c.(9292-9294)ACG>ATG	p.T3098M	AHNAK2_uc001ypx.2_Missense_Mutation_p.T2998M	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3098						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTCGGGGGCCGTCACGTCCGT	0.627													A	105412495	A	A	105412495	3	1	35	1	0	0	0	0	1	0	0	0	415	1145	40	1	8098	1	AHNAK2	14	105412495	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	29892223	105412495	1937045	73	2237											
MAPKBP1	23005	broad.mit.edu	37	chr15	42111153	42111153	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaagggcttctggacccaaCcggtgagaacagaatgtggg	14	9	1	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr15:42111153C>T	uc001zok.3	+	21	2593	c.2307C>T	c.(2305-2307)AAC>AAT	p.N769N	MAPKBP1_uc001zoj.3_Silent_p.N763N|MAPKBP1_uc010bcj.2_Silent_p.N270N|MAPKBP1_uc010bci.2_Silent_p.N763N|MAPKBP1_uc010udb.1_Silent_p.N602N|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Silent_p.N270N	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	769								p.N763N(1)		central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CTGGACCCAACCGGTGAGAAC	0.607													T	42111153	T	T	42111153	2	4	35	1	0	0	0	0	0	0	0	1	9292	506	18	3		3	MAPKBP1	15	42111153	Silent	SNP	C	TCGA-06-0174-01A-01D-1491-08		42111153	60420239	74	2238											
ZSCAN29	146050	broad.mit.edu	37	chr15	43653907	43653907	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctcccaagcaaggtctctgTtgacttaggacttcacttaa	7	11	3	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr15:43653907T>G	uc001zrk.1	-	5	2070	c.1923A>C	c.(1921-1923)CAA>CAC	p.Q641H	ZSCAN29_uc001zrj.1_Missense_Mutation_p.Q521H|ZSCAN29_uc010bdf.1_3'UTR|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Missense_Mutation_p.Q251H	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	641					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		AAGGTCTCTGTTGACTTAGGA	0.473													G	43653907	G	G	43653907	3	3	35	1	0	0	0	0	1	0	0	0	18233	1722	60	5	639	5	ZSCAN29	15	43653907	Missense_Mutation	SNP	T	TCGA-06-0174-01A-01D-1491-08	1542754	43653907	58877485	75	2239											
SSTR5	6755	broad.mit.edu	37	chr16	1129417	1129417	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgcggacgtgcaggagggCggtacctgcaacgccagctg	16	12	0	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr16:1129417C>T	uc002ckq.2	+	1	637	c.549C>T	c.(547-549)GGC>GGT	p.G183G	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	183	Extracellular (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	TGCAGGAGGGCGGTACCTGCA	0.716													T	1129417	T	T	1129417	2	4	35	1	0	0	0	0	0	0	0	1	15200	755	27	1		1	SSTR5	16	1129417	Silent	SNP	C	TCGA-06-0174-01A-01D-1491-08		1129417	89225336	76	2240											
TMC5	79838	broad.mit.edu	37	chr16	19451842	19451842	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcattttggctccttagaacCggactaccctggagctcaga	9	12	2	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr16:19451842C>T	uc002dgc.3	+	3	1231	c.482C>T	c.(481-483)CCG>CTG	p.P161L	TMC5_uc010vaq.1_Missense_Mutation_p.P161L|TMC5_uc002dgb.3_Missense_Mutation_p.P161L|TMC5_uc010var.1_Missense_Mutation_p.P161L	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	161	Extracellular (Potential).					integral to membrane				skin(1)	1						TCCTTAGAACCGGACTACCCT	0.478													T	19451842	T	T	19451842	3	4	35	1	0	0	0	0	1	0	0	0	15985	652	23	2	484	2	TMC5	16	19451842	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	18322425	19451842	70902911	77	2241											
OTOA	146183	broad.mit.edu	37	chr16	21689852	21689852	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaatgtctcaggaacctaCgacatactcccttttcctat	6	12	1	1	rs144912852		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr16:21689852C>T	uc002djh.2	+	1	18	c.17C>T	c.(16-18)ACG>ATG	p.T6M	uc002diq.3_Intron	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	6					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		CAGGAACCTACGACATACTCC	0.333													T	21689852	T	T	21689852	3	4	35	1	0	0	0	0	1	0	0	0	11302	536	19	1	19	1	OTOA	16	21689852	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	2238010	21689852	68664901	78	2242											
GTF3C1	2975	broad.mit.edu	37	chr16	27518426	27518426	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgctctcctctgcaaacaCgcaggaaatgtacttggtgg	11	11	2	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr16:27518426C>T	uc002dov.1	-	9	1334	c.1294G>A	c.(1294-1296)GTG>ATG	p.V432M	GTF3C1_uc002dou.2_Missense_Mutation_p.V432M	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	432						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TCTGCAAACACGCAGGAAATG	0.552													T	27518426	T	T	27518426	3	4	35	1	0	0	0	0	1	0	0	0	6872	536	19	1	5151	1	GTF3C1	16	27518426	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	5828574	27518426	62836327	79	2243											
MFSD6L	162387	broad.mit.edu	37	chr17	8701786	8701786	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aattggctggattcccgggcCctttccccccaggaagcaag	11	14	0	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr17:8701786C>A	uc002glp.1	-	1	801	c.653G>T	c.(652-654)GGG>GTG	p.G218V		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	218						integral to membrane				central_nervous_system(1)	1						ATTCCCGGGCCCTTTCCCCCC	0.577													A	8701786	A	A	8701786	3	1	35	1	0	0	0	0	1	0	0	0	9536	623	22	5	1111	5	MFSD6L	17	8701786	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08		8701786	72493424	80	2244											
UNC45B	146862	broad.mit.edu	37	chr17	33504108	33504108	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccacgctctagcaaagatcGctgctgtctccaatccggac	8	16	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr17:33504108G>A	uc002hja.2	+	16	2201	c.2104G>A	c.(2104-2106)GCT>ACT	p.A702T	UNC45B_uc002hjb.2_Missense_Mutation_p.A700T|UNC45B_uc002hjc.2_Missense_Mutation_p.A700T|UNC45B_uc010cto.2_Missense_Mutation_p.A621T	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	702					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				AGCAAAGATCGCTGCTGTCTC	0.572													A	33504108	A	A	33504108	3	1	35	1	0	0	0	0	1	0	0	0	16986	1087	38	1	2162	1	UNC45B	17	33504108	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	24802322	33504108	47691102	81	2245											
SCN4A	6329	broad.mit.edu	37	chr17	62025418	62025418	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgctcaatgtagatgtcctcGaaggcctgggggcaccagca	13	11	1	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr17:62025418G>A	uc002jds.1	-	17	3227	c.3150C>T	c.(3148-3150)TTC>TTT	p.F1050F		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1050	III.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	AGATGTCCTCGAAGGCCTGGG	0.602													A	62025418	A	A	62025418	2	1	35	1	0	0	0	0	0	0	0	1	13920	1049	37	2		2	SCN4A	17	62025418	Silent	SNP	G	TCGA-06-0174-01A-01D-1491-08	28521310	62025418	19169792	82	2246											
AZI1	22994	broad.mit.edu	37	chr17	79170626	79170626	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtgaggtctcgctgctgcgCctgcagggtgtgggcagagg	19	10	1	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr17:79170626C>T	uc002jzp.1	-	15	1983	c.1783G>A	c.(1783-1785)GCG>ACG	p.A595T	AZI1_uc002jzm.1_Missense_Mutation_p.A22T|AZI1_uc002jzn.1_Missense_Mutation_p.A592T|AZI1_uc002jzo.1_Missense_Mutation_p.A592T|AZI1_uc010wum.1_Missense_Mutation_p.A595T|AZI1_uc002jzq.2_5'Flank	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	595					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CGCTGCTGCGCCTGCAGGGTG	0.687													T	79170626	T	T	79170626	3	4	35	1	0	0	0	0	1	0	0	0	1240	753	26	3	1516	3	AZI1	17	79170626	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	17145208	79170626	2024584	83	2247											
FBN3	84467	broad.mit.edu	37	chr19	8162272	8162272	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgccattggcacagatggCggggatctccccacactcat	11	13	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr19:8162272C>T	uc002mjf.2	-	41	5209	c.5188G>A	c.(5188-5190)GCC>ACC	p.A1730T		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1730	EGF-like 26; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GCACAGATGGCGGGGATCTCC	0.597													T	8162272	T	T	8162272	3	4	35	1	0	0	0	0	1	0	0	0	5704	768	27	1	3333	1	FBN3	19	8162272	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08		8162272	50966711	84	2248											
UNC13A	23025	broad.mit.edu	37	chr19	17769035	17769035	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgttgctcgtttcactgcgGtagtcactgtcacgatcatc	9	12	4	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr19:17769035G>T	uc002nhd.2	-	10	867	c.867C>A	c.(865-867)TAC>TAA	p.Y289*		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	201					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						TTTCACTGCGGTAGTCACTGT	0.562													T	17769035	T	T	17769035	4	4	35	1	0	0	0	0	0	1	0	0	16981	1256	44	5	4644	5	UNC13A	19	17769035	Nonsense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	9606763	17769035	41359948	85	2249											
MAG	4099	broad.mit.edu	37	chr19	35793483	35793483	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagaagcagatcctgtccaCggtcatctacgagagcgagc	13	11	2	3	rs144554089		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr19:35793483C>T	uc002nyy.1	+	7	1252	c.1103C>T	c.(1102-1104)ACG>ATG	p.T368M	MAG_uc002nyx.1_Missense_Mutation_p.T368M|MAG_uc010eds.1_Missense_Mutation_p.T343M|MAG_uc002nyz.1_Missense_Mutation_p.T368M	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	368	Ig-like C2-type 3.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding	p.T368M(1)		breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			ATCCTGTCCACGGTCATCTAC	0.582													T	35793483	T	T	35793483	3	4	35	1	0	0	0	0	1	0	0	0	9162	536	19	1	1121	1	MAG	19	35793483	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	18024448	35793483	23335500	86	2250											
RYR1	6261	broad.mit.edu	37	chr19	38958338	38958338	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagagcggccgctggtacttCgagtttgaagcagtcaccac	12	12	1	2			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr19:38958338C>T	uc002oit.2	+	25	3397	c.3267C>T	c.(3265-3267)TTC>TTT	p.F1089F	RYR1_uc002oiu.2_Silent_p.F1089F	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1089	6 X approximate repeats.|Cytoplasmic.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCTGGTACTTCGAGTTTGAAG	0.592													T	38958338	T	T	38958338	2	4	35	1	0	0	0	0	0	0	0	1	13768	883	31	2		2	RYR1	19	38958338	Silent	SNP	C	TCGA-06-0174-01A-01D-1491-08	3164855	38958338	20170645	87	2251											
CYP2S1	29785	broad.mit.edu	37	chr19	41700569	41700569	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcaggctgaggagttcagcGgccggggaaccgtagcgatg	18	9	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr19:41700569G>A	uc002opw.2	+	2	353	c.298G>A	c.(298-300)GGC>AGC	p.G100S	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_5'UTR	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	100					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						GGAGTTCAGCGGCCGGGGAAC	0.592													A	41700569	A	A	41700569	3	1	35	1	0	0	0	0	1	0	0	0	4174	1116	39	2	304	2	CYP2S1	19	41700569	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	2742231	41700569	17428414	88	2252											
SCAF1	58506	broad.mit.edu	37	chr19	50157645	50157645	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatggaagaagccaacctggCgagccgagcgaaggcccagg	16	11	0	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr19:50157645C>T	uc002poq.2	+	8	3480	c.3356C>T	c.(3355-3357)GCG>GTG	p.A1119V		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1119					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GCCAACCTGGCGAGCCGAGCG	0.607													T	50157645	T	T	50157645	3	4	35	1	0	0	0	0	1	0	0	0	13868	768	27	1	3382	1	SCAF1	19	50157645	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	8457076	50157645	8971338	89	2253											
NLRP13	126204	broad.mit.edu	37	chr19	56424553	56424553	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgctgcagttcctcatgttcGtcctttgatgtattacggat	9	10	1	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr19:56424553G>A	uc010ygg.1	-	5	655	c.630C>T	c.(628-630)GAC>GAT	p.D210D		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	210							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CCTCATGTTCGTCCTTTGATG	0.498													A	56424553	A	A	56424553	2	1	35	1	0	0	0	0	0	0	0	1	10475	1136	40	1		1	NLRP13	19	56424553	Silent	SNP	G	TCGA-06-0174-01A-01D-1491-08	6266908	56424553	2704430	90	2254											
ZSWIM3	140831	broad.mit.edu	37	chr20	44506102	44506102	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagatctttcctgctgcccGcatcctcctttccatctacc	6	17	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr20:44506102G>A	uc002xqd.2	+	2	1108	c.905G>A	c.(904-906)CGC>CAC	p.R302H	ZSWIM3_uc010zxg.1_Missense_Mutation_p.R296H	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	302							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				CCTGCTGCCCGCATCCTCCTT	0.502													A	44506102	A	A	44506102	3	1	35	1	0	0	0	0	1	0	0	0	18239	1087	38	1	911	1	ZSWIM3	20	44506102	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08		44506102	18519418	91	2255											
KRTAP15-1	254950	broad.mit.edu	37	chr21	31812738	31812738	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acttataatttgttctacccCagcaatgccatctattctcc	3	13	3	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr21:31812738C>A	uc002yod.2	+	1	93	c.93C>A	c.(91-93)CCC>CCA	p.P31P		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	31						intermediate filament					0						TGTTCTACCCCAGCAATGCCA	0.478													A	31812738	A	A	31812738	2	1	35	1	0	0	0	0	0	0	0	1	8526	581	21	5		5	KRTAP15-1	21	31812738	Silent	SNP	C	TCGA-06-0174-01A-01D-1491-08		31812738	16317157	92	2256											
DERL3	91319	broad.mit.edu	37	chr22	24179323	24179323	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtcctccaggaagtagtagAtatggcccaccgcaatccct	9	14	0	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr22:24179323A>G	uc002zyh.2	-	6	567	c.542T>C	c.(541-543)ATC>ACC	p.I181T	DERL3_uc002zyk.3_Missense_Mutation_p.I181T|DERL3_uc002zyi.2_Missense_Mutation_p.I181T|DERL3_uc002zyj.2_Silent_p.Y137Y	NM_001002862	NP_001002862	Q96Q80	DERL3_HUMAN	derlin 3 isoform 2	181	Cytoplasmic (Potential).				endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	integral to endoplasmic reticulum membrane	protein binding			ovary(1)	1						GAAGTAGTAGATATGGCCCAC	0.632													G	24179323	G	G	24179323	3	3	35	1	0	0	0	0	1	0	0	0	4448	333	12	4	287	4	DERL3	22	24179323	Missense_Mutation	SNP	A	TCGA-06-0174-01A-01D-1491-08		24179323	27125243	93	2257											
SYN3	8224	broad.mit.edu	37	chr22	32909719	32909719	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaaagacttcctcaggttgCggatggtttcagccttggcc	11	11	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr22:32909719C>T	uc003amx.2	-	13	1862	c.1703G>A	c.(1702-1704)CGC>CAC	p.R568H	SYN3_uc003amy.2_3'UTR|SYN3_uc003amz.2_Missense_Mutation_p.R567H	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	568	E.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						CCTCAGGTTGCGGATGGTTTC	0.572													T	32909719	T	T	32909719	3	4	35	1	0	0	0	0	1	0	0	0	15439	768	27	1	43	1	SYN3	22	32909719	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	8730396	32909719	18394847	94	2258											
NAGA	4668	broad.mit.edu	37	chr22	42458918	42458918	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaatgtccatgttctgggcGgagatggtacgcaggtctgt	15	7	2	2	rs144984228		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chr22:42458918G>A	uc003bbx.2	-	8	1007	c.870C>T	c.(868-870)TCC>TCT	p.S290S	NAGA_uc003bby.2_Silent_p.S290S|NAGA_uc003bbw.3_Silent_p.S290S	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	290					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						TGTTCTGGGCGGAGATGGTAC	0.557													A	42458918	A	A	42458918	2	1	35	1	0	0	0	0	0	0	0	1	10141	1103	39	2		2	NAGA	22	42458918	Silent	SNP	G	TCGA-06-0174-01A-01D-1491-08	9549199	42458918	8845648	95	2259											
AMELX	265	broad.mit.edu	37	chrX	11316747	11316747	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgtcccaacagcacccccCgactcacaccctgcagcctc	6	22	1	0	rs148259441		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chrX:11316747C>T	uc004cut.2	+	5	292	c.224C>T	c.(223-225)CCG>CTG	p.P75L	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Missense_Mutation_p.P89L|AMELX_uc004cuu.2_Missense_Mutation_p.P59L	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	75					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						CAGCACCCCCCGACTCACACC	0.602													T	11316747	T	T	11316747	3	4	35	1	0	0	0	0	1	0	0	0	569	652	23	2	284	2	AMELX	23	11316747	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08		11316747	143953813	96	2260											
ZCCHC16	340595	broad.mit.edu	37	chrX	111698312	111698312	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	catatctgggcctgacaagaGtaccttactgaagcaatatg	9	9	1	3	rs149089921		TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chrX:111698312G>C	uc004epo.1	+	3	797	c.356G>C	c.(355-357)AGT>ACT	p.S119T		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	119							nucleic acid binding|zinc ion binding			ovary(1)	1						CCTGACAAGAGTACCTTACTG	0.383													C	111698312	C	C	111698312	3	2	35	1	0	0	0	0	1	0	0	0	17581	1029	36	5	358	5	ZCCHC16	23	111698312	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08	100381565	111698312	43572248	97	2261											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299765	125299765	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatagtgcaccagcctgcgaCgcgtcgccggccgcttctgc	13	16	1	0			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chrX:125299765C>T	uc004euk.1	-	1	170	c.143G>A	c.(142-144)CGT>CAT	p.R48H		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	48										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CAGCCTGCGACGCGTCGCCGG	0.731													T	125299765	T	T	125299765	3	4	35	1	0	0	0	0	1	0	0	0	4265	536	19	1	1252	1	DCAF12L2	23	125299765	Missense_Mutation	SNP	C	TCGA-06-0174-01A-01D-1491-08	13601453	125299765	29970795	98	2262											
AFF2	2334	broad.mit.edu	37	chrX	147967460	147967460	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgagcagtgatgaagatgAccttgagcctgtgaagacct	13	8	0	8			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chrX:147967460A>G	uc004fcp.2	+	8	1783	c.1304A>G	c.(1303-1305)GAC>GGC	p.D435G	AFF2_uc004fco.2_Missense_Mutation_p.D396G|AFF2_uc004fcq.2_Missense_Mutation_p.D425G|AFF2_uc004fcr.2_Missense_Mutation_p.D396G|AFF2_uc011mxb.1_Missense_Mutation_p.D400G|AFF2_uc004fcs.2_Missense_Mutation_p.D402G|AFF2_uc011mxc.1_Missense_Mutation_p.D76G	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	435					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GATGAAGATGACCTTGAGCCT	0.483													G	147967460	G	G	147967460	3	3	35	1	0	0	0	0	1	0	0	0	357	275	10	4	1389	4	AFF2	23	147967460	Missense_Mutation	SNP	A	TCGA-06-0174-01A-01D-1491-08	22667695	147967460	7303100	99	2263											
TGIF2LY	90655	broad.mit.edu	37	chrY	3447632	3447632	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccggatatgcttcaacagcGtagaaacgaccccatcattg	8	13	2	1			TCGA-06-0174-01A-01D-1491-08	TCGA-06-0174-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	017c9167-0354-41e4-ad50-fb38fcb5668c	aa54fbd5-8afc-454e-a9af-9f0d59e12853	g.chrY:3447632G>A	uc004fqk.2	+	2	411	c.347G>A	c.(346-348)CGT>CAT	p.R116H		NM_139214	NP_631960	Q8IUE0	TF2LY_HUMAN	TGFB-induced factor homeobox 2-like, Y-linked	116						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTTCAACAGCGTAGAAACGAC	0.527													A	3447632	A	A	3447632	3	1	35	1	0	0	0	0	1	0	0	0	15825	1145	40	1	349	1	TGIF2LY	24	3447632	Missense_Mutation	SNP	G	TCGA-06-0174-01A-01D-1491-08		3447632	55925934	100	2264											
SFT2D1	113402	broad.mit.edu	37	chr6	166739646	166739646	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agcagcacacagggtaaataTgaaacacaactacaggggaa	10	8	0	1	rs11551053	byFrequency	TCGA-06-0178-01A-01D-1491-08	TCGA-06-0178-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4fa779b-d116-4696-b170-60f3e215e9fb	c9f63961-b124-468a-bff1-62c1aedd1805	g.chr6:166739646T>C	uc003qux.2	-	5	355	c.325A>G	c.(325-327)ATA>GTA	p.I109V		NM_145169	NP_660152	Q8WV19	SFT2A_HUMAN	SFT2 domain containing 1	109	Helical; Name=3; (Potential).				protein transport|vesicle-mediated transport	integral to membrane		p.I109V(1)		central_nervous_system(1)	1		Breast(66;0.000148)|Prostate(117;0.109)|Ovarian(120;0.199)		OV - Ovarian serous cystadenocarcinoma(33;2.63e-19)|BRCA - Breast invasive adenocarcinoma(81;4.92e-06)|GBM - Glioblastoma multiforme(31;4.58e-05)		AGGGTAAATATGAAACACAAC	0.413													C	166739646	C	C	166739646	3	2	36	1	0	0	0	0	1	0	0	0	14185	1464	51	4	170	4	SFT2D1	6	166739646	Missense_Mutation	SNP	T	TCGA-06-0178-01A-01D-1491-08		166739646	4375421	1	2265											
MYO1D	4642	broad.mit.edu	37	chr17	31203857	31203857	+	Frame_Shift_Del	DEL	C	-	-													gtccatcagcacgaagtctgCcttgccgaattccaggctct							TCGA-06-0178-01A-01D-1491-08	TCGA-06-0178-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4fa779b-d116-4696-b170-60f3e215e9fb	c9f63961-b124-468a-bff1-62c1aedd1805	g.chr17:31203857delC	uc002hho.1	-	1	46	c.34delG	c.(34-36)GCAfs	p.A12fs	MYO1D_uc002hhp.1_Frame_Shift_Del_p.A12fs|MYO1D_uc010wcb.1_Frame_Shift_Del_p.A12fs	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	12	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			ACGAAGTCTGCCTTGCCGAAT	0.726													-	31203857	-	-	31203857	7	5	36	1	0	1	0	1	0	0	0	0	10071	739	26	0	3074	0	MYO1D	17	31203857	Frame_Shift_Del	DEL	C	TCGA-06-0178-01A-01D-1491-08		31203857	49991353	2	2266											
SPSB1	80176	broad.mit.edu	37	chr1	9416221	9416221	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggacgctatcaggggcaaaGtcgggtatacccgtgggctg	16	10	1	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr1:9416221G>A	uc010oae.1	+	2	610	c.271G>A	c.(271-273)GTC>ATC	p.V91I	SPSB1_uc001apv.2_Missense_Mutation_p.V91I	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	91	B30.2/SPRY.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		CAGGGGCAAAGTCGGGTATAC	0.632													A	9416221	A	A	9416221	3	1	37	1	0	0	0	0	1	0	0	0	15111	1029	36	3	273	3	SPSB1	1	9416221	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08		9416221	239834400	1	2267											
CYP4B1	1580	broad.mit.edu	37	chr1	47279693	47279693	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actggctcaccccacatggcCgccgcttcctgcgggcctgc	11	19	1	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr1:47279693C>T	uc001cqm.3	+	6	814	c.730C>T	c.(730-732)CGC>TGC	p.R244C	CYP4B1_uc009vyl.1_Missense_Mutation_p.R81C|CYP4B1_uc001cqn.3_Missense_Mutation_p.R245C|CYP4B1_uc009vym.2_Missense_Mutation_p.R230C|CYP4B1_uc010omk.1_Missense_Mutation_p.R81C|CYP4B1_uc010oml.1_Missense_Mutation_p.R82C	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	244					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CCCACATGGCCGCCGCTTCCT	0.592													T	47279693	T	T	47279693	3	4	37	1	0	0	0	0	1	0	0	0	4185	652	23	2	755	2	CYP4B1	1	47279693	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08	37863472	47279693	201970928	2	2268											
CD1D	912	broad.mit.edu	37	chr1	158151257	158151257	+	Frame_Shift_Del	DEL	T	-	-													tctcccagtcccgcaaaggcTtttccccctccgctgcctcc							TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr1:158151257delT	uc001frr.2	+	3	573	c.74delT	c.(73-75)CTTfs	p.L25fs	CD1D_uc009wsr.1_Frame_Shift_Del_p.L25fs|CD1D_uc009wss.2_Frame_Shift_Del_p.L25fs|CD1D_uc009wst.1_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	25	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CCGCAAAGGCTTTTCCCCCTC	0.592													-	158151257	-	-	158151257	7	5	37	1	0	1	0	1	0	0	0	0	2977	1609	56	0	80	0	CD1D	1	158151257	Frame_Shift_Del	DEL	T	TCGA-06-0184-01A-01D-1491-08	110871564	158151257	91099364	3	2269											
GPR161	23432	broad.mit.edu	37	chr1	168065791	168065791	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcctggaagtcctctgtcGttgcacaaatggttcccgat	11	11	1	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr1:168065791G>A	uc001gfc.2	-	5	1368	c.1054C>T	c.(1054-1056)CGA>TGA	p.R352*	GPR161_uc001gfb.2_Nonsense_Mutation_p.R220*|GPR161_uc010pll.1_Nonsense_Mutation_p.R262*|GPR161_uc010plm.1_Nonsense_Mutation_p.R238*|GPR161_uc009wvo.2_Nonsense_Mutation_p.R369*|GPR161_uc001gfd.2_Nonsense_Mutation_p.R352*|GPR161_uc010pln.1_Nonsense_Mutation_p.R372*|GPR161_uc001gfe.1_Nonsense_Mutation_p.R352*	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	352	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					GTCCTCTGTCGTTGCACAAAT	0.512													A	168065791	A	A	168065791	4	1	37	1	0	0	0	0	0	1	0	0	6665	1153	40	1	551	1	GPR161	1	168065791	Nonsense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	9914534	168065791	81184830	4	2270											
HMCN1	83872	broad.mit.edu	37	chr1	186008959	186008959	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggtattcctgccccaagtcTgacctggttgaaagatggga	12	9	1	3			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr1:186008959T>C	uc001grq.1	+	39	6357	c.6128T>C	c.(6127-6129)CTG>CCG	p.L2043P		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2043	Ig-like C2-type 18.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GCCCCAAGTCTGACCTGGTTG	0.443													C	186008959	C	C	186008959	3	2	37	1	0	0	0	0	1	0	0	0	7220	1580	55	4	6282	4	HMCN1	1	186008959	Missense_Mutation	SNP	T	TCGA-06-0184-01A-01D-1491-08	17943168	186008959	63241662	5	2271											
DSTYK	25778	broad.mit.edu	37	chr1	205129369	205129369	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccacaccatactggccccGgcccagttcctgtcccagtt	7	18	0	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr1:205129369G>A	uc001hbw.2	-	8	2042	c.1978C>T	c.(1978-1980)CGG>TGG	p.R660W	DSTYK_uc001hbx.2_Missense_Mutation_p.R660W|DSTYK_uc001hby.1_Missense_Mutation_p.R121W	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	660	Protein kinase.|ATP (By similarity).					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						TACTGGCCCCGGCCCAGTTCC	0.498													A	205129369	A	A	205129369	3	1	37	1	0	0	0	0	1	0	0	0	4785	1115	39	2	835	2	DSTYK	1	205129369	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	19120410	205129369	44121252	6	2272											
TRIM58	25893	broad.mit.edu	37	chr1	248023987	248023987	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccttgactcaggaggccaaCgtggggaaaaagactgtcat	13	9	2	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr1:248023987C>T	uc001ido.2	+	2	537	c.489C>T	c.(487-489)AAC>AAT	p.N163N		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	163						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGGAGGCCAACGTGGGGAAAA	0.483													T	248023987	T	T	248023987	2	4	37	1	0	0	0	0	0	0	0	1	16528	535	19	1		1	TRIM58	1	248023987	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08	42894618	248023987	1226634	7	2273											
GPR45	11250	broad.mit.edu	37	chr2	105859310	105859310	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggagaatcaaaaaattccGcgaggcctgcatagagttgc	11	9	1	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr2:105859310G>A	uc002tco.1	+	1	1111	c.995G>A	c.(994-996)CGC>CAC	p.R332H		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	332	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						AAAAAATTCCGCGAGGCCTGC	0.557													A	105859310	A	A	105859310	3	1	37	1	0	0	0	0	1	0	0	0	6696	1087	38	1	997	1	GPR45	2	105859310	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08		105859310	137340063	8	2274											
ITGA4	3676	broad.mit.edu	37	chr2	182360642	182360642	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttgtttctcatataagggCaaggaagttccaggttacat	9	7	1	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr2:182360642C>T	uc002unu.2	+	14	2281	c.1518C>T	c.(1516-1518)GGC>GGT	p.G506G	ITGA4_uc010frj.1_5'Flank	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	506	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CATATAAGGGCAAGGAAGTTC	0.428													T	182360642	T	T	182360642	2	4	37	1	0	0	0	0	0	0	0	1	7878	697	25	3		3	ITGA4	2	182360642	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08	76501332	182360642	60838731	9	2275											
ZDBF2	57683	broad.mit.edu	37	chr2	207175047	207175047	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctcctaagcaaaaggggcGtgtggcttctcaatgccaga	12	11	1	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr2:207175047G>A	uc002vbp.2	+	5	6045	c.5795G>A	c.(5794-5796)CGT>CAT	p.R1932H		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1932							nucleic acid binding|zinc ion binding			ovary(3)	3						CAAAAGGGGCGTGTGGCTTCT	0.433													A	207175047	A	A	207175047	3	1	37	1	0	0	0	0	1	0	0	0	17596	1145	40	1	5805	1	ZDBF2	2	207175047	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	24814405	207175047	36024326	10	2276											
THRB	7068	broad.mit.edu	37	chr3	24231704	24231704	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgactgttcatttttcaaCgtgctgcgcctctctgaatg	9	11	3	1	rs138865141		TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr3:24231704C>T	uc003ccx.3	-	5	493	c.144G>A	c.(142-144)ACG>ACA	p.T48T	THRB_uc010hfe.2_Silent_p.T48T|THRB_uc003ccy.3_Silent_p.T48T|THRB_uc003ccz.3_Silent_p.T43T|THRB_uc003cdc.2_Silent_p.T43T|THRB_uc003cdd.2_Silent_p.T43T|THRB_uc003cde.1_Silent_p.T43T	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	48	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)	CATTTTTCAACGTGCTGCGCC	0.493													T	24231704	T	T	24231704	2	4	37	1	0	0	0	0	0	0	0	1	15872	523	19	1		1	THRB	3	24231704	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08		24231704	173790726	11	2277											
BSN	8927	broad.mit.edu	37	chr3	49691996	49691996	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actgcagtggtagacctccgTacagctgtcaagcccactcc	9	15	1	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr3:49691996T>C	uc003cxe.3	+	5	5121	c.5007T>C	c.(5005-5007)CGT>CGC	p.R1669R		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1669					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TAGACCTCCGTACAGCTGTCA	0.597													C	49691996	C	C	49691996	2	2	37	1	0	0	0	0	0	0	0	1	1530	1625	57	4		4	BSN	3	49691996	Silent	SNP	T	TCGA-06-0184-01A-01D-1491-08	25460292	49691996	148330434	12	2278											
BSN	8927	broad.mit.edu	37	chr3	49693009	49693009	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatcgggcagctcttccaggGtcctggacgagactcggcta	14	12	1	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr3:49693009G>A	uc003cxe.3	+	5	6134	c.6020G>A	c.(6019-6021)GGT>GAT	p.G2007D		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2007					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTCTTCCAGGGTCCTGGACGA	0.597													A	49693009	A	A	49693009	3	1	37	1	0	0	0	0	1	0	0	0	1530	1261	44	3	6038	3	BSN	3	49693009	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	1013	49693009	148329421	13	2279											
CCDC66	285331	broad.mit.edu	37	chr3	56651395	56651395	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgaagaaatatcctaaaaGgcctgattggaatataaata	7	5	0	3			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr3:56651395G>A	uc003dhz.2	+	14	2186	c.2099G>A	c.(2098-2100)AGG>AAG	p.R700K	CCDC66_uc003dhy.2_Missense_Mutation_p.R336K|CCDC66_uc003dhu.2_Missense_Mutation_p.R666K|CCDC66_uc003dhx.2_RNA|CCDC66_uc003dia.2_Missense_Mutation_p.R68K	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	700										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		TATCCTAAAAGGCCTGATTGG	0.353													A	56651395	A	A	56651395	3	1	37	1	0	0	0	0	1	0	0	0	2838	1000	35	3	2153	3	CCDC66	3	56651395	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	6958386	56651395	141371035	14	2280											
CADPS	8618	broad.mit.edu	37	chr3	62860671	62860671	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctcctcctccacgatctcatCcgattcttcttcgctggacg	6	17	3	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr3:62860671C>G	uc003dll.2	-	1	394	c.34G>C	c.(34-36)GAT>CAT	p.D12H	CADPS_uc003dlm.2_Missense_Mutation_p.D12H|CADPS_uc003dln.2_Missense_Mutation_p.D12H	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	12					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ACGATCTCATCCGATTCTTCT	0.697													G	62860671	G	G	62860671	3	3	37	1	0	0	0	0	1	0	0	0	2570	855	30	5	4220	5	CADPS	3	62860671	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08	6209276	62860671	135161759	15	2281											
PDZRN3	23024	broad.mit.edu	37	chr3	73673955	73673955	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgggtccacgtcgccgtcgaAgcggtccagctcgaagccca	13	16	0	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr3:73673955A>G	uc003dpl.1	-	1	118	c.22T>C	c.(22-24)TTC>CTC	p.F8L		NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	8							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCGCCGTCGAAGCGGTCCAGC	0.557													G	73673955	G	G	73673955	3	3	37	1	0	0	0	0	1	0	0	0	11709	72	3	4	3218	4	PDZRN3	3	73673955	Missense_Mutation	SNP	A	TCGA-06-0184-01A-01D-1491-08	10813284	73673955	124348475	16	2282											
CNTN3	5067	broad.mit.edu	37	chr3	74535739	74535739	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcctccattcaacttataacGatgttccatactcatatcaa	2	12	3	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr3:74535739G>A	uc003dpm.1	-	3	306	c.226C>T	c.(226-228)CGT>TGT	p.R76C		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	76	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AACTTATAACGATGTTCCATA	0.353													A	74535739	A	A	74535739	3	1	37	1	0	0	0	0	1	0	0	0	3642	1058	37	2	2940	2	CNTN3	3	74535739	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	861784	74535739	123486691	17	2283											
MCM2	4171	broad.mit.edu	37	chr3	127318380	127318380	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagaggagctcattggagatGgcatggaaaggtaatttcat	14	4	2	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr3:127318380G>A	uc003ejp.2	+	2	283	c.226G>A	c.(226-228)GGC>AGC	p.G76S	MCM2_uc011bkm.1_5'UTR|MCM2_uc010hsl.2_RNA	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	76	Interaction with MYST2 (By similarity).				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						CATTGGAGATGGCATGGAAAG	0.567													A	127318380	A	A	127318380	3	1	37	1	0	0	0	0	1	0	0	0	9386	1348	47	3	232	3	MCM2	3	127318380	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	52782641	127318380	70704050	18	2284											
RUFY3	22902	broad.mit.edu	37	chr4	71644115	71644115	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaacaaccttcaggcaaaagTagatgcattagaaaaatcca	6	8	1	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr4:71644115T>A	uc003hfq.2	+	8	1449	c.854T>A	c.(853-855)GTA>GAA	p.V285E	RUFY3_uc003hfp.3_Missense_Mutation_p.V345E|RUFY3_uc011cax.1_Missense_Mutation_p.V303E|RUFY3_uc003hfr.2_Missense_Mutation_p.V285E|RUFY3_uc011cay.1_Missense_Mutation_p.V221E	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	285	Potential.				negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			CAGGCAAAAGTAGATGCATTA	0.313													A	71644115	A	A	71644115	3	1	37	1	0	0	0	0	1	0	0	0	13740	1638	57	5	1246	5	RUFY3	4	71644115	Missense_Mutation	SNP	T	TCGA-06-0184-01A-01D-1491-08		71644115	119510161	19	2285											
LARP1B	55132	broad.mit.edu	37	chr4	128999066	128999066	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaacaaaattaaatggtcctGgtgaaaacgtcagtgaggat	10	5	1	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr4:128999066G>C	uc003iga.2	+	4	297	c.166G>C	c.(166-168)GGT>CGT	p.G56R	LARP1B_uc003ifw.1_Missense_Mutation_p.G56R|LARP1B_uc003ifx.2_Missense_Mutation_p.G56R|LARP1B_uc003ify.2_Missense_Mutation_p.G56R|LARP1B_uc003ifz.1_Missense_Mutation_p.G56R	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	56							RNA binding				0						AAATGGTCCTGGTGAAAACGT	0.343													C	128999066	C	C	128999066	3	2	37	1	0	0	0	0	1	0	0	0	8629	1348	47	5	172	5	LARP1B	4	128999066	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	57354951	128999066	62155210	20	2286											
PHF17	79960	broad.mit.edu	37	chr4	129770219	129770219	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tctgagcctcccgagttgggCtatgtggacatccggacgct	13	12	1	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr4:129770219C>G	uc003igk.2	+	5	661	c.381C>G	c.(379-381)GGC>GGG	p.G127G	PHF17_uc003igj.2_Silent_p.G127G|PHF17_uc003igl.2_Silent_p.G115G|PHF17_uc011cgy.1_Silent_p.G127G|PHF17_uc003igm.2_Silent_p.G127G	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	127					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						CCGAGTTGGGCTATGTGGACA	0.488													G	129770219	G	G	129770219	2	3	37	1	0	0	0	0	0	0	0	1	11828	784	28	5		5	PHF17	4	129770219	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08	771153	129770219	61384057	21	2287											
PCDH18	54510	broad.mit.edu	37	chr4	138442740	138442740	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttgcgttgggaattcttcccCtggaatgaacatgttactcc	9	10	1	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr4:138442740C>G	uc003ihe.3	-	4	3238	c.2851G>C	c.(2851-2853)GGG>CGG	p.G951R	PCDH18_uc003ihf.3_Missense_Mutation_p.G943R|PCDH18_uc011cgz.1_Missense_Mutation_p.G162R|PCDH18_uc003ihg.3_Missense_Mutation_p.G730R|PCDH18_uc011cha.1_Missense_Mutation_p.G131R	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	951	Interaction with DAB1 (By similarity).|Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					AATTCTTCCCCTGGAATGAAC	0.532													G	138442740	G	G	138442740	3	3	37	1	0	0	0	0	1	0	0	0	11513	681	24	5	560	5	PCDH18	4	138442740	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08	8672521	138442740	52711536	22	2288											
CDH18	1016	broad.mit.edu	37	chr5	19747261	19747261	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtggatatcacccgtggtatCgtcaatgataaatatagtcc	9	8	2	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr5:19747261C>T	uc003jgc.2	-	3	690	c.313G>A	c.(313-315)GAT>AAT	p.D105N	CDH18_uc003jgd.2_Missense_Mutation_p.D105N|CDH18_uc011cnm.1_Missense_Mutation_p.D105N	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	105	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CCCGTGGTATCGTCAATGATA	0.438													T	19747261	T	T	19747261	3	4	37	1	0	0	0	0	1	0	0	0	3103	884	31	2	2099	2	CDH18	5	19747261	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08		19747261	161167999	23	2289											
ADAMTS12	81792	broad.mit.edu	37	chr5	33683134	33683134	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaatgttacctcttcttcttCgagtagaatgagccgaacca	7	10	3	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr5:33683134C>T	uc003jia.1	-	5	1067	c.904G>A	c.(904-906)GAA>AAA	p.E302K	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E302K	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	302	Poly-Glu.|Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCTTCTTCTTCGAGTAGAATG	0.423										HNSCC(64;0.19)			T	33683134	T	T	33683134	3	4	37	1	0	0	0	0	1	0	0	0	257	893	31	2	3960	2	ADAMTS12	5	33683134	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08	13935873	33683134	147232126	24	2290											
MATR3	9782	broad.mit.edu	37	chr5	138657666	138657666	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaagccctttggtttcaggGgagatgtgtgaaggttgacc	14	6	1	3			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr5:138657666G>A	uc003ldu.2	+	13	2109	c.1682G>A	c.(1681-1683)GGG>GAG	p.G561E	MATR3_uc010jfb.2_Missense_Mutation_p.G561E|MATR3_uc003ldt.2_Missense_Mutation_p.G223E|MATR3_uc003ldw.2_Missense_Mutation_p.G561E|MATR3_uc003ldx.2_Missense_Mutation_p.G561E|MATR3_uc010jfc.2_Missense_Mutation_p.G561E|MATR3_uc003ldy.2_Missense_Mutation_p.G238E|MATR3_uc011czb.1_Missense_Mutation_p.G273E|MATR3_uc003ldz.2_Missense_Mutation_p.G561E|MATR3_uc003lea.2_Missense_Mutation_p.G561E|MATR3_uc003leb.2_Missense_Mutation_p.G223E|MATR3_uc003lec.2_Missense_Mutation_p.G238E	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	561	RRM 2.					nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGGTTTCAGGGGAGATGTGTG	0.348													A	138657666	A	A	138657666	3	1	37	1	0	0	0	0	1	0	0	0	9337	1232	43	3	1716	3	MATR3	5	138657666	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	104974532	138657666	42257594	25	2291											
PCDHGC3	5098	broad.mit.edu	37	chr5	140856716	140856716	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttggtggaggttgtggatGtgaatgacaacgccccggag	17	6	0	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr5:140856716G>A	uc003lkv.1	+	1	1148	c.1033G>A	c.(1033-1035)GTG>ATG	p.V345M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.V345M|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	345	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTTGTGGATGTGAATGACAA	0.547													A	140856716	A	A	140856716	3	1	37	1	0	0	0	0	1	0	0	0	11569	1377	48	3	1035	3	PCDHGC3	5	140856716	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	2199050	140856716	40058544	26	2292											
EBF1	1879	broad.mit.edu	37	chr5	158140057	158140057	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcacgcccatcatccctgcGtggaccgaggtgttagcaag	11	13	2	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr5:158140057G>A	uc010jip.2	-	13	1592	c.1290C>T	c.(1288-1290)CAC>CAT	p.H430H	EBF1_uc011ddw.1_Silent_p.H298H|EBF1_uc011ddx.1_Silent_p.H431H|EBF1_uc003lxl.3_Silent_p.H399H	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	430					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCATCCCTGCGTGGACCGAGG	0.557			T	HMGA2	lipoma								A	158140057	A	A	158140057	2	1	37	1	0	0	0	0	0	0	0	1	4880	1136	40	1		1	EBF1	5	158140057	Silent	SNP	G	TCGA-06-0184-01A-01D-1491-08	17283341	158140057	22775203	27	2293											
FGD2	221472	broad.mit.edu	37	chr6	36993651	36993651	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgagtctgcctccactgctaCgcattcctcactggaaatgt	8	14	2	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr6:36993651C>T	uc010jwp.1	+	14	1713	c.1542C>T	c.(1540-1542)TAC>TAT	p.Y514Y	FGD2_uc003ong.2_Silent_p.Y236Y|FGD2_uc011dtv.1_Silent_p.Y142Y|FGD2_uc003onj.1_Silent_p.Y91Y	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	514	FYVE-type.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						TCCACTGCTACGCATTCCTCA	0.612													T	36993651	T	T	36993651	2	4	37	1	0	0	0	0	0	0	0	1	5833	547	19	1		1	FGD2	6	36993651	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08		36993651	134121416	28	2294											
REV3L	5980	broad.mit.edu	37	chr6	111696862	111696862	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tttctaacgttccatctccaAagtgacagtctataaaacca	4	11	3	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr6:111696862A>T	uc003puy.3	-	13	3019	c.2696T>A	c.(2695-2697)TTT>TAT	p.F899Y	REV3L_uc003pux.3_Missense_Mutation_p.F821Y|REV3L_uc003puz.3_Missense_Mutation_p.F821Y	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	899					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TCCATCTCCAAAGTGACAGTC	0.378								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					T	111696862	T	T	111696862	3	4	37	1	0	0	0	0	1	0	0	0	13240	14	1	5	6776	5	REV3L	6	111696862	Missense_Mutation	SNP	A	TCGA-06-0184-01A-01D-1491-08	74703211	111696862	59418205	29	2295											
DNAH11	8701	broad.mit.edu	37	chr7	21698496	21698496	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagaagccatagtggcctaCgaggaaaaacctagggaact	11	9	0	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr7:21698496C>T	uc003svc.2	+	30	5221	c.5190C>T	c.(5188-5190)TAC>TAT	p.Y1730Y		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1730	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TAGTGGCCTACGAGGAAAAAC	0.443									Kartagener_syndrome				T	21698496	T	T	21698496	2	4	37	1	0	0	0	0	0	0	0	1	4599	547	19	1		1	DNAH11	7	21698496	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08		21698496	137440167	30	2296											
GNAT3	346562	broad.mit.edu	37	chr7	80088110	80088110	+	Frame_Shift_Del	DEL	T	-	-													gaataaatttccttatcttcTttttttaaattcaggtctag							TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr7:80088110delT	uc011kgu.1	-	8	942	c.942delA	c.(940-942)AAAfs	p.K314fs	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	314					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						CCTTATCTTCTTTTTTTAAAT	0.328													-	80088110	-	-	80088110	7	5	37	1	0	1	0	1	0	0	0	0	6513	1606	56	0	124	0	GNAT3	7	80088110	Frame_Shift_Del	DEL	T	TCGA-06-0184-01A-01D-1491-08	58389614	80088110	79050553	31	2297											
ZAN	7455	broad.mit.edu	37	chr7	100364655	100364655	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gccgccacctgcacagcctcGggtgacccccactacctgac	9	20	0	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr7:100364655G>T	uc003uwj.2	+	25	4800	c.4635G>T	c.(4633-4635)TCG>TCT	p.S1545S	ZAN_uc003uwk.2_Silent_p.S1545S|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Silent_p.S122S	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1545	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCACAGCCTCGGGTGACCCCC	0.607													T	100364655	T	T	100364655	2	4	37	1	0	0	0	0	0	0	0	1	17510	1103	39	5		5	ZAN	7	100364655	Silent	SNP	G	TCGA-06-0184-01A-01D-1491-08	20276545	100364655	58774008	32	2298											
CUL1	8454	broad.mit.edu	37	chr7	148457457	148457457	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaatgaagatgatgcatttGcaaagggccctacgttaaca	10	7	0	4			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr7:148457457G>A	uc010lpg.2	+	7	1184	c.658G>A	c.(658-660)GCA>ACA	p.A220T	CUL1_uc003wey.2_Missense_Mutation_p.A220T|CUL1_uc003wez.2_Missense_Mutation_p.A110T	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	220					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TGATGCATTTGCAAAGGGCCC	0.338													A	148457457	A	A	148457457	3	1	37	1	0	0	0	0	1	0	0	0	4054	1319	46	3	680	3	CUL1	7	148457457	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	48092802	148457457	10681206	33	2299											
CNTLN	54875	broad.mit.edu	37	chr9	17135249	17135249	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctgggtgggtgaagaaggGtcagggggccggcgagggcc	22	7	2	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr9:17135249G>A	uc003zmz.2	+	1	212	c.186G>A	c.(184-186)GGG>GGA	p.G62G	CNTLN_uc003zmx.3_Silent_p.G62G|CNTLN_uc003zmy.2_Silent_p.G62G|CNTLN_uc003zmw.1_Silent_p.G62G	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	62						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		GTGAAGAAGGGTCAGGGGGCC	0.672													A	17135249	A	A	17135249	2	1	37	1	0	0	0	0	0	0	0	1	3639	1248	44	3		3	CNTLN	9	17135249	Silent	SNP	G	TCGA-06-0184-01A-01D-1491-08		17135249	124078182	34	2300											
TEK	7010	broad.mit.edu	37	chr9	27229172	27229172	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagacctacgtgaataccaCgctttatgagaagtttactt	7	10	0	3			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr9:27229172C>T	uc003zqi.3	+	23	3759	c.3317C>T	c.(3316-3318)ACG>ATG	p.T1106M	TEK_uc011lno.1_Missense_Mutation_p.T1063M|TEK_uc011lnp.1_Missense_Mutation_p.T958M	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	1106	Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.T1106M(1)		ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GTGAATACCACGCTTTATGAG	0.453													T	27229172	T	T	27229172	3	4	37	1	0	0	0	0	1	0	0	0	15748	536	19	1	3407	1	TEK	9	27229172	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08	10093923	27229172	113984259	35	2301											
NFX1	4799	broad.mit.edu	37	chr9	33294757	33294757	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatcagagtcaagaaagcacAgagtcttgctgagcagacct	10	9	3	5	rs147195056		TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr9:33294757A>C	uc003zsq.2	+	2	426	c.365A>C	c.(364-366)CAG>CCG	p.Q122P	SUGT1P1_uc010mjq.1_Intron|NFX1_uc011lnw.1_Missense_Mutation_p.Q122P|NFX1_uc003zso.2_Missense_Mutation_p.Q122P|NFX1_uc003zsp.1_Missense_Mutation_p.Q122P|NFX1_uc010mjr.1_Missense_Mutation_p.Q122P|NFX1_uc003zsr.2_Missense_Mutation_p.Q122P	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	122					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		AAGAAAGCACAGAGTCTTGCT	0.483													C	33294757	C	C	33294757	3	2	37	1	0	0	0	0	1	0	0	0	10387	188	7	5	371	5	NFX1	9	33294757	Missense_Mutation	SNP	A	TCGA-06-0184-01A-01D-1491-08	6065585	33294757	107918674	36	2302											
ZNF33B	7582	broad.mit.edu	37	chr10	43088980	43088980	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gacaaaaggatttcccacacTcaagacattcaaaaggtttc	6	10	2	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr10:43088980T>C	uc001jaf.1	-	5	1533	c.1418A>G	c.(1417-1419)GAG>GGG	p.E473G	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.E361G|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	473	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTTCCCACACTCAAGACATTC	0.383													C	43088980	C	C	43088980	3	2	37	1	0	0	0	0	1	0	0	0	17852	1551	54	4	922	4	ZNF33B	10	43088980	Missense_Mutation	SNP	T	TCGA-06-0184-01A-01D-1491-08		43088980	92445767	37	2303											
PTEN	5728	broad.mit.edu	37	chr10	89653809	89653809	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tccaaacattattgctatggGatttcctgcagaaagacttg	8	8	0	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr10:89653809G>A	uc001kfb.2	+	3	1138	c.107G>A	c.(106-108)GGA>GAA	p.G36E		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	36	Phosphatase tensin-type.		G -> R (in endometrial hyperplasia).|G -> E (in glioma).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(4)|p.G36E(4)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G36V(2)|p.G36fs*18(1)|p.G36*(1)|p.A34_G36del(1)|p.G36R(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ATTGCTATGGGATTTCCTGCA	0.284		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89653809	A	A	89653809	3	1	37	1	0	0	0	0	1	0	0	0	12738	1174	41	3	113	3	PTEN	10	89653809	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	46564829	89653809	45880938	38	2304											
GPR120	338557	broad.mit.edu	37	chr10	95347103	95347103	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctcatggtctccttcttcAtcatgtggagccccatcatc	6	15	6	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr10:95347103A>C	uc010qnt.1	+	4	927	c.871A>C	c.(871-873)ATC>CTC	p.I291L	GPR120_uc010qnu.1_Missense_Mutation_p.I275L	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	G protein-coupled receptor 120	291	Helical; Name=6; (Potential).				negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding				0		Colorectal(252;0.122)				CTCCTTCTTCATCATGTGGAG	0.582													C	95347103	C	C	95347103	3	2	37	1	0	0	0	0	1	0	0	0	6636	217	8	5	885	5	GPR120	10	95347103	Missense_Mutation	SNP	A	TCGA-06-0184-01A-01D-1491-08	5693294	95347103	40187644	39	2305											
MUC2	4583	broad.mit.edu	37	chr11	1101144	1101144	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccacggaggtcaaccctgccGacacctgctgcaacattacc	8	17	1	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr11:1101144G>A	uc001lsx.1	+	44	14656	c.14629G>A	c.(14629-14631)GAC>AAC	p.D4877N		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4877	VWFC 1.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CAACCCTGCCGACACCTGCTG	0.622													A	1101144	A	A	1101144	3	1	37	1	0	0	0	0	1	0	0	0	9975	1058	37	2	7697	2	MUC2	11	1101144	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08		1101144	133905372	40	2306											
OR51T1	401665	broad.mit.edu	37	chr11	4903141	4903141	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	caaccaaccatggcaatattCaataacaccacttcgtcttc	3	14	2	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr11:4903141C>A	uc010qyp.1	+	1	93	c.93C>A	c.(91-93)TTC>TTA	p.F31L		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	4	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCAATATTCAATAACACCA	0.368													A	4903141	A	A	4903141	3	1	37	1	0	0	0	0	1	0	0	0	11106	825	29	5	95	5	OR51T1	11	4903141	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08	3801997	4903141	130103375	41	2307											
OR10A6	390093	broad.mit.edu	37	chr11	7949484	7949484	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcacagatgtgaggtgagcGgcacaggtggaaaaggcctt	16	7	1	3			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr11:7949484G>A	uc010rbh.1	-	1	726	c.726C>T	c.(724-726)GCC>GCT	p.A242A		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGAGGTGAGCGGCACAGGTGG	0.453													A	7949484	A	A	7949484	2	1	37	1	0	0	0	0	0	0	0	1	10894	1103	39	2		2	OR10A6	11	7949484	Silent	SNP	G	TCGA-06-0184-01A-01D-1491-08	3046343	7949484	127057032	42	2308											
MADD	8567	broad.mit.edu	37	chr11	47345856	47345856	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgaaggacagcatggagcGcgctgccgcccgacagcaaa	14	12	0	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr11:47345856G>A	uc001ner.1	+	32	4774	c.4583G>A	c.(4582-4584)CGC>CAC	p.R1528H	MADD_uc001neq.2_Missense_Mutation_p.R1469H|MADD_uc001nev.1_Missense_Mutation_p.R1426H|MADD_uc001nes.1_Missense_Mutation_p.R1446H|MADD_uc001net.1_Missense_Mutation_p.R1489H|MADD_uc009yln.1_Missense_Mutation_p.R1422H|MADD_uc001neu.1_Missense_Mutation_p.R1426H|MADD_uc001nex.2_Missense_Mutation_p.R1528H|MADD_uc001nez.2_Missense_Mutation_p.R1425H|MADD_uc001new.2_Missense_Mutation_p.R1468H|MADD_uc009ylo.2_Missense_Mutation_p.R442H	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1528					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		AGCATGGAGCGCGCTGCCGCC	0.592													A	47345856	A	A	47345856	3	1	37	1	0	0	0	0	1	0	0	0	9152	1087	38	1	4705	1	MADD	11	47345856	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	39396372	47345856	87660660	43	2309											
MS4A7	58475	broad.mit.edu	37	chr11	60150731	60150731	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgaagattacctgcagaaCgggctgccaacagaaaccac	9	12	0	3			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr11:60150731C>T	uc001npe.2	+	2	262	c.117C>T	c.(115-117)AAC>AAT	p.N39N	MS4A7_uc001npf.2_Silent_p.N39N|MS4A7_uc001npg.2_Silent_p.N39N|MS4A7_uc001nph.2_Silent_p.N39N|MS4A14_uc001npi.2_Intron|MS4A7_uc009ymx.1_Silent_p.N39N	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	39	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						ACCTGCAGAACGGGCTGCCAA	0.438													T	60150731	T	T	60150731	2	4	37	1	0	0	0	0	0	0	0	1	9866	535	19	1		1	MS4A7	11	60150731	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08	12804875	60150731	74855785	44	2310											
NADSYN1	55191	broad.mit.edu	37	chr11	71191823	71191823	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcagggcgagcccctaccCcagagtgaaggtggactttg	14	12	0	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr11:71191823C>T	uc001oqn.2	+	11	1022	c.896C>T	c.(895-897)CCC>CTC	p.P299L	NADSYN1_uc001oqo.2_Missense_Mutation_p.P39L|NADSYN1_uc001oqp.2_5'UTR	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	299	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGCCCCTACCCCAGAGTGAAG	0.587													T	71191823	T	T	71191823	3	4	37	1	0	0	0	0	1	0	0	0	10138	623	22	3	938	3	NADSYN1	11	71191823	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08	11041092	71191823	63814693	45	2311											
SPATA19	219938	broad.mit.edu	37	chr11	133714446	133714446	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctggccatgggtgggaggGgagtcagtggacatcttctc	16	9	3	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr11:133714446G>A	uc001qgv.1	-	3	276	c.225C>T	c.(223-225)TCC>TCT	p.S75S		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	75					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		GGGTGGGAGGGGAGTCAGTGG	0.552													A	133714446	A	A	133714446	2	1	37	1	0	0	0	0	0	0	0	1	15003	1219	43	3		3	SPATA19	11	133714446	Silent	SNP	G	TCGA-06-0184-01A-01D-1491-08	62522623	133714446	1292070	46	2312											
C12orf50	160419	broad.mit.edu	37	chr12	88379716	88379716	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcgggaaggtgcattcaacGcgacagtcctgacagcatct	12	11	2	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr12:88379716G>A	uc001tam.1	-	11	1205	c.1037C>T	c.(1036-1038)GCG>GTG	p.A346V	C12orf50_uc001tan.2_Missense_Mutation_p.A361V	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	346										skin(2)|ovary(1)	3						TGCATTCAACGCGACAGTCCT	0.478													A	88379716	A	A	88379716	3	1	37	1	0	0	0	0	1	0	0	0	1695	1087	38	1	219	1	C12orf50	12	88379716	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08		88379716	45472179	47	2313											
TPTE2	93492	broad.mit.edu	37	chr13	20039688	20039688	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aataataagtcgtagaagtcGaactaaatgtgtccatctaa	7	6	1	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr13:20039688G>A	uc001umd.2	-	9	740	c.529C>T	c.(529-531)CGA>TGA	p.R177*	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Nonsense_Mutation_p.R66*|TPTE2_uc001ume.2_Nonsense_Mutation_p.R100*|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	177						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CGTAGAAGTCGAACTAAATGT	0.289													A	20039688	A	A	20039688	4	1	37	1	0	0	0	0	0	1	0	0	16428	1066	37	2	1091	2	TPTE2	13	20039688	Nonsense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08		20039688	95130190	48	2314											
ZC3H13	23091	broad.mit.edu	37	chr13	46544544	46544544	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgtccggagaatgttcaCgccggcgcttcggggactgt	14	12	1	1	rs144621814		TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr13:46544544C>T	uc010tfw.1	-	12	2531	c.2525G>A	c.(2524-2526)CGT>CAT	p.R842H	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Missense_Mutation_p.R842H|ZC3H13_uc001vat.1_Missense_Mutation_p.R842H	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	842	Arg/Glu-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		AGAATGTTCACGCCGGCGCTT	0.438													T	46544544	T	T	46544544	3	4	37	1	0	0	0	0	1	0	0	0	17562	536	19	1	2189	1	ZC3H13	13	46544544	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08	26504856	46544544	68625334	49	2315											
RB1	5925	broad.mit.edu	37	chr13	49033823	49033823	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	taatttttcttattcccacaGtgtatcggctagcctatctc	5	11	2	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr13:49033823G>T	uc001vcb.2	+	20	2127	c.1961_splice	c.e20-1	p.V654_splice		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(10)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TATTCCCACAGTGTATCGGCT	0.363		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	49033823	T	T	49033823	5	4	37	1	0	0	0	0	0	0	1	0	13098	1043	36	5	2038	5	RB1	13	49033823	Splice_Site	SNP	G	TCGA-06-0184-01A-01D-1491-08	2489279	49033823	66136055	50	2316											
SYNE2	23224	broad.mit.edu	37	chr14	64496750	64496750	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcctgtggatcaaatagcGgttgaggaaaaattgcagaa	12	5	1	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr14:64496750G>A	uc001xgm.2	+	44	7082	c.6852G>A	c.(6850-6852)GCG>GCA	p.A2284A	SYNE2_uc001xgl.2_Silent_p.A2284A	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2284	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATCAAATAGCGGTTGAGGAAA	0.363													A	64496750	A	A	64496750	2	1	37	1	0	0	0	0	0	0	0	1	15443	1103	39	2		2	SYNE2	14	64496750	Silent	SNP	G	TCGA-06-0184-01A-01D-1491-08		64496750	42852790	51	2317											
PROX2	283571	broad.mit.edu	37	chr14	75329430	75329430	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgaggaggggtgcctctGggaagatgagtcctggggag	19	7	2	3			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr14:75329430G>A	uc001xqr.1	-	1	1108	c.1108C>T	c.(1108-1110)CAG>TAG	p.Q370*	PROX2_uc001xqq.1_Intron	NM_001080408	NP_001073877	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	370					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GGGTGCCTCTGGGAAGATGAG	0.542													A	75329430	A	A	75329430	4	1	37	1	0	0	0	0	0	1	0	0	12561	1357	47	3	686	3	PROX2	14	75329430	Nonsense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	10832680	75329430	32020110	52	2318											
KCNK10	54207	broad.mit.edu	37	chr14	88729810	88729810	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggaggaaatggacaggcgCggagttggagtcggagccgg	21	7	0	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr14:88729810C>T	uc001xwo.2	-	2	580	c.123G>A	c.(121-123)CCG>CCA	p.P41P	KCNK10_uc001xwm.2_Silent_p.P46P|KCNK10_uc001xwn.2_Silent_p.P46P	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	41	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						TGGACAGGCGCGGAGTTGGAG	0.652													T	88729810	T	T	88729810	2	4	37	1	0	0	0	0	0	0	0	1	8059	755	27	1		1	KCNK10	14	88729810	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08	13400380	88729810	18619730	53	2319											
ISLR	3671	broad.mit.edu	37	chr15	74467595	74467595	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgctcaagatggacagcaaCgagctgaccttcatcccccg	9	14	2	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr15:74467595C>T	uc002axg.1	+	2	678	c.396C>T	c.(394-396)AAC>AAT	p.N132N	ISLR_uc002axh.1_Silent_p.N132N	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	132	LRR 4.				cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TGGACAGCAACGAGCTGACCT	0.592													T	74467595	T	T	74467595	2	4	37	1	0	0	0	0	0	0	0	1	7858	535	19	1		1	ISLR	15	74467595	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08		74467595	28063797	54	2320											
CHP2	63928	broad.mit.edu	37	chr16	23767768	23767768	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctccaggcatgagatgctgCaggttggcagaaagcgagag	15	8	1	3			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr16:23767768C>T	uc002dmb.1	+	5	835	c.412C>T	c.(412-414)CAG>TAG	p.Q138*		NM_022097	NP_071380	O43745	CHP2_HUMAN	hepatocellular carcinoma antigen gene 520	138	EF-hand 3.						calcium ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(48;0.0144)		TGAGATGCTGCAGGTTGGCAG	0.537													T	23767768	T	T	23767768	4	4	37	1	0	0	0	0	0	1	0	0	3367	711	25	3	430	3	CHP2	16	23767768	Nonsense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08		23767768	66586985	55	2321											
CES1	1066	broad.mit.edu	37	chr16	55855414	55855414	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggtgaccccagttcccccGgctgtgttcatcccctgtgc	10	17	1	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr16:55855414G>A	uc002eim.2	-	5	664	c.556C>T	c.(556-558)CGG>TGG	p.R186W	CES1_uc002eil.2_Missense_Mutation_p.R187W|CES1_uc002ein.2_Missense_Mutation_p.R186W	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	186				R -> G (in Ref. 18; CAA37147).	response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	CAGTTCCCCCGGCTGTGTTCA	0.602													A	55855414	A	A	55855414	3	1	37	1	0	0	0	0	1	0	0	0	3269	1115	39	2	1187	2	CES1	16	55855414	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	32087646	55855414	34499339	56	2322											
TP53	7157	broad.mit.edu	37	chr17	7578457	7578457	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttgtagatggccatggcgCggacgcgggtgccgggcggg	21	10	0	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr17:7578457C>T	uc002gim.2	-	5	667	c.473G>A	c.(472-474)CGC>CAC	p.R158H	TP53_uc002gig.1_Missense_Mutation_p.R158H|TP53_uc002gih.2_Missense_Mutation_p.R158H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26H|TP53_uc010cng.1_Missense_Mutation_p.R26H|TP53_uc002gii.1_Missense_Mutation_p.R26H|TP53_uc010cnh.1_Missense_Mutation_p.R158H|TP53_uc010cni.1_Missense_Mutation_p.R158H|TP53_uc002gij.2_Missense_Mutation_p.R158H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65H|TP53_uc002gio.2_Missense_Mutation_p.R26H|TP53_uc010vug.1_Missense_Mutation_p.R119H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578457	T	T	7578457	3	4	37	1	0	0	0	0	1	0	0	0	16378	768	27	1	825	1	TP53	17	7578457	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08		7578457	73616753	57	2323											
NF1	4763	broad.mit.edu	37	chr17	29665808	29665808	+	Frame_Shift_Del	DEL	G	-	-													atagcactaaccaaattacaGccacttcttaataaggtaat							TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr17:29665808delG	uc002hgg.2	+	46	7239	c.6906delG	c.(6904-6906)CAGfs	p.Q2302fs	NF1_uc002hgh.2_Frame_Shift_Del_p.Q2281fs|NF1_uc010cso.2_Frame_Shift_Del_p.Q490fs|NF1_uc010wbt.1_Intron|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2302					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.Q2302fs*17(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CCAAATTACAGCCACTTCTTA	0.333			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29665808	-	-	29665808	7	5	37	1	0	1	0	1	0	0	0	0	10356	962	34	0	7149	0	NF1	17	29665808	Frame_Shift_Del	DEL	G	TCGA-06-0184-01A-01D-1491-08	22087351	29665808	51529402	58	2324											
SLC25A39	51629	broad.mit.edu	37	chr17	42400868	42400868	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagagagaggtaaccacagcCccggtgcctgaggccaccat	12	13	0	3			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr17:42400868C>T	uc002ign.2	-	2	217	c.63G>A	c.(61-63)GGG>GGA	p.G21G	SLC25A39_uc002igm.2_Silent_p.G21G|SLC25A39_uc002igo.2_Silent_p.G21G|SLC25A39_uc010wiw.1_Silent_p.G21G|SLC25A39_uc010czu.2_Intron|SLC25A39_uc010wix.1_Silent_p.G21G|SLC25A39_uc010wiy.1_Silent_p.G21G	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	21	Solcar 1.|Helical; Name=1; (Potential).				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TAACCACAGCCCCGGTGCCTG	0.617													T	42400868	T	T	42400868	2	4	37	1	0	0	0	0	0	0	0	1	14503	610	22	3		3	SLC25A39	17	42400868	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08	12735060	42400868	38794342	59	2325											
UNC13D	201294	broad.mit.edu	37	chr17	73827417	73827417	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgagtgtgtgggtccagagCagggtcaggaggctggggcg	22	6	1	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr17:73827417C>T	uc002jpp.2	-	26	2840	c.2460G>A	c.(2458-2460)CTG>CTA	p.L820L	UNC13D_uc010wsk.1_Silent_p.L820L|UNC13D_uc002jpq.1_3'UTR	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	820	MHD2.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGGTCCAGAGCAGGGTCAGGA	0.667									Familial_Hemophagocytic_Lymphohistiocytosis				T	73827417	T	T	73827417	2	4	37	1	0	0	0	0	0	0	0	1	16984	697	25	3		3	UNC13D	17	73827417	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08	31426549	73827417	7367793	60	2326											
SEMA6B	10501	broad.mit.edu	37	chr19	4555533	4555533	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tggggtcgtacgggcagcggGccataccgctgatgttgtct	16	10	1	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr19:4555533G>C	uc010duc.1	-	6	553	c.515C>G	c.(514-516)GCC>GGC	p.A172G	SEMA6B_uc010dud.2_Missense_Mutation_p.A172G|SEMA6B_uc010xih.1_Missense_Mutation_p.A172G	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	172	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGCAGCGGGCCATACCGCT	0.622													C	4555533	C	C	4555533	3	2	37	1	0	0	0	0	1	0	0	0	14040	1203	42	5	2195	5	SEMA6B	19	4555533	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08		4555533	54573450	61	2327											
ILF3	3609	broad.mit.edu	37	chr19	10799315	10799315	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcacacgggggctacggcGgaggttctgggggcggctcc	20	11	2	0			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr19:10799315G>A	uc002mpn.2	+	19	2829	c.2512G>A	c.(2512-2514)GGA>AGA	p.G838R	ILF3_uc002mpo.2_Missense_Mutation_p.G842R|ILF3_uc002mpq.2_Silent_p.A140A	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	838	Interaction with PRMT1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GGGCTACGGCGGAGGTTCTGG	0.667													A	10799315	A	A	10799315	3	1	37	1	0	0	0	0	1	0	0	0	7712	1117	39	2	2666	2	ILF3	19	10799315	Missense_Mutation	SNP	G	TCGA-06-0184-01A-01D-1491-08	6243782	10799315	48329668	62	2328											
ANGPT4	51378	broad.mit.edu	37	chr20	858921	858921	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctgcccttctggtgagctggTgcaccacttcattgcccagc	10	15	2	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr20:858921T>A	uc002wei.2	-	7	1206	c.1103A>T	c.(1102-1104)CAC>CTC	p.H368L	ANGPT4_uc010zpn.1_Missense_Mutation_p.H362L	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	368	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						GGTGAGCTGGTGCACCACTTC	0.612													A	858921	A	A	858921	3	1	37	1	0	0	0	0	1	0	0	0	612	1696	59	5	420	5	ANGPT4	20	858921	Missense_Mutation	SNP	T	TCGA-06-0184-01A-01D-1491-08		858921	62166599	63	2329											
CHGB	1114	broad.mit.edu	37	chr20	5903619	5903619	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacctctgaggtggacaaaCgacgcacgaggcccagacac	11	15	1	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr20:5903619C>T	uc002wmg.2	+	4	1135	c.829C>T	c.(829-831)CGA>TGA	p.R277*	CHGB_uc010zqz.1_Translation_Start_Site	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	277						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GGTGGACAAACGACGCACGAG	0.607													T	5903619	T	T	5903619	4	4	37	1	0	0	0	0	0	1	0	0	3339	528	19	1	843	1	CHGB	20	5903619	Nonsense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08	5044698	5903619	57121901	64	2330											
RNF160	26046	broad.mit.edu	37	chr21	30354691	30354691	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataagatgatcctgcagcacCtacaaaggggggaaatacca	10	9	0	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr21:30354691C>T	uc002ymr.2	-	5	728	c.715_splice	c.e5-1	p.V239_splice	RNF160_uc010gll.1_Splice_Site	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294								ligase activity|zinc ion binding				0						CCTGCAGCACCTACAAAGGGG	0.378													T	30354691	T	T	30354691	5	4	37	1	0	0	0	0	0	0	1	0	13455	695	24	3	4828	3	RNF160	21	30354691	Splice_Site	SNP	C	TCGA-06-0184-01A-01D-1491-08		30354691	17775204	65	2331											
EIF3L	51386	broad.mit.edu	37	chr22	38274115	38274115	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagaacctcgtgtggaccagCggtatctcagccctggatgg	13	11	1	1			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chr22:38274115C>T	uc003auf.2	+	11	1599	c.1512C>T	c.(1510-1512)AGC>AGT	p.S504S	EIF3L_uc003aue.1_Silent_p.S504S|EIF3L_uc011ann.1_Silent_p.S456S|EIF3L_uc003aug.2_Silent_p.S396S|EIF3L_uc003auh.2_Silent_p.S237S	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	504						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						TGTGGACCAGCGGTATCTCAG	0.517													T	38274115	T	T	38274115	2	4	37	1	0	0	0	0	0	0	0	1	5022	767	27	1		1	EIF3L	22	38274115	Silent	SNP	C	TCGA-06-0184-01A-01D-1491-08		38274115	13030451	66	2332											
BTK	695	broad.mit.edu	37	chrX	100611084	100611084	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgactccaggtattccatggCttcacagacatccttgcaca	7	13	1	2			TCGA-06-0184-01A-01D-1491-08	TCGA-06-0184-10B-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5a2e50f-dc7e-44cc-bffe-b675a707bf53	8f733c6d-f060-4e6b-8695-89f2b7174419	g.chrX:100611084C>T	uc004ehg.2	-	15	1715	c.1522G>A	c.(1522-1524)GCC>ACC	p.A508T	BTK_uc004ehf.2_Missense_Mutation_p.A8T|BTK_uc010nnh.2_Intron|BTK_uc010nni.2_Intron|BTK_uc004ehe.2_Intron|BTK_uc010nnj.2_RNA|BTK_uc010nnk.2_Intron|BTK_uc010nnl.2_Intron|BTK_uc010nnm.2_Missense_Mutation_p.A78T|BTK_uc010nnn.2_Intron|BTK_uc010nno.2_Missense_Mutation_p.A542T|BTK_uc004ehh.1_Intron|BTK_uc004ehi.2_Missense_Mutation_p.A508T	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	508	Protein kinase.		A -> D (in XLA).		calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding	p.A508T(1)		lung(3)|central_nervous_system(2)|ovary(1)	6						TATTCCATGGCTTCACAGACA	0.547									Agammaglobulinemia_X-linked				T	100611084	T	T	100611084	3	4	37	1	0	0	0	0	1	0	0	0	1557	797	28	3	477	3	BTK	23	100611084	Missense_Mutation	SNP	C	TCGA-06-0184-01A-01D-1491-08		100611084	54659476	67	2333											
ACAP3	116983	broad.mit.edu	37	chr1	1229200	1229201	+	Splice_Site	DEL	CA	-	-													cccgagggcccggccgcgctCacagtgtcacgatgtcagcg							TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:1229200_1229201delCA	uc001aeb.2	-	23	2434	c.2360_splice	c.e23+1	p.L787_splice	ACAP3_uc001ady.2_Splice_Site_p.L517_splice|ACAP3_uc001aea.2_Splice_Site_p.L712_splice	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH						filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						CGGCCGCGCTCACAGTGTCACG	0.752													-	1229201	-	-	1229200	8	5	38	1	0	1	0	1	0	0	1	0	120	841	29	0		0	ACAP3	1	1229200	Splice_Site	DEL	CA	TCGA-06-0185-01A-01W-0254-08		1229200	248021421	1	2334											
TMCO4	255104	broad.mit.edu	37	chr1	20027271	20027271	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggacagacctgcagtagcCgttgatgatcctcccggaca	11	12	0	3			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:20027271C>T	uc001bcn.2	-	14	1614	c.1372G>A	c.(1372-1374)GGC>AGC	p.G458S	TMCO4_uc001bcm.2_Missense_Mutation_p.G289S|TMCO4_uc001bco.1_Missense_Mutation_p.G458S|TMCO4_uc001bcp.1_Missense_Mutation_p.G418S	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	458						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		CTGCAGTAGCCGTTGATGATC	0.433													T	20027271	T	T	20027271	3	4	38	1	0	0	0	0	1	0	0	0	15995	652	23	2	544	2	TMCO4	1	20027271	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	18798071	20027271	229223350	2	2335											
HOOK1	51361	broad.mit.edu	37	chr1	60299185	60299185	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagcttattttaggttgtGcgatcaactgtgaaaagaag	10	6	1	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:60299185G>A	uc009wad.2	+	6	484	c.382G>A	c.(382-384)GCG>ACG	p.A128T	HOOK1_uc001czo.2_Missense_Mutation_p.A128T|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Missense_Mutation_p.A86T	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	128	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					TTTAGGTTGTGCGATCAACTG	0.373													A	60299185	A	A	60299185	3	1	38	1	0	0	0	0	1	0	0	0	7282	1319	46	3	400	3	HOOK1	1	60299185	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	40271914	60299185	188951436	3	2336											
RBMXL1	494115	broad.mit.edu	37	chr1	89448530	89448530	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gatcacttcggctgcttgagTaactgtctcgacttccacca	8	13	2	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:89448530T>A	uc009wcx.2	-	3	1696	c.980A>T	c.(979-981)TAC>TTC	p.Y327F	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.Y327F	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	327	Ser-rich.						nucleotide binding|RNA binding				0						GCTGCTTGAGTAACTGTCTCG	0.517													A	89448530	A	A	89448530	3	1	38	1	0	0	0	0	1	0	0	0	13153	1638	57	5	196	5	RBMXL1	1	89448530	Missense_Mutation	SNP	T	TCGA-06-0185-01A-01W-0254-08	29149345	89448530	159802091	4	2337											
SPTA1	6708	broad.mit.edu	37	chr1	158622276	158622276	+	Frame_Shift_Del	DEL	T	-	-													ccttttggaactcatcaaacTttttctgcagctcccaaaca							TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:158622276delT	uc001fst.1	-	23	3555	c.3356delA	c.(3355-3357)AAGfs	p.K1119fs		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1119	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTCATCAAACTTTTTCTGCAG	0.398													-	158622276	-	-	158622276	7	5	38	1	0	1	0	1	0	0	0	0	15115	1609	56	0	4023	0	SPTA1	1	158622276	Frame_Shift_Del	DEL	T	TCGA-06-0185-01A-01W-0254-08	69173746	158622276	90628345	5	2338											
DDR2	4921	broad.mit.edu	37	chr1	162749912	162749912	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttcccaaagacttacctccCtcaaccagccatttgtcctg	5	16	1	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:162749912C>T	uc001gcf.2	+	19	2909	c.2444C>T	c.(2443-2445)CCT>CTT	p.P815L	DDR2_uc001gcg.2_Missense_Mutation_p.P815L|uc001gch.1_5'Flank	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	815	Cytoplasmic (Potential).|Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.P815L(1)		lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			ACTTACCTCCCTCAACCAGCC	0.438													T	162749912	T	T	162749912	3	4	38	1	0	0	0	0	1	0	0	0	4337	681	24	3	2506	3	DDR2	1	162749912	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	4127636	162749912	86500709	6	2339											
SMG7	9887	broad.mit.edu	37	chr1	183511445	183511445	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggttaccttcaaagaaaaCattaagacacgagaagtgaa	9	6	1	4			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:183511445C>T	uc001gqg.2	+	14	1772	c.1650C>T	c.(1648-1650)AAC>AAT	p.N550N	SMG7_uc010pob.1_Silent_p.N579N|SMG7_uc001gqf.2_Silent_p.N550N|SMG7_uc001gqh.2_Silent_p.N550N|SMG7_uc001gqi.2_Silent_p.N508N|SMG7_uc010poc.1_Silent_p.N508N	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	550					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCAAAGAAAACATTAAGACAC	0.428													T	183511445	T	T	183511445	2	4	38	1	0	0	0	0	0	0	0	1	14798	477	17	3		3	SMG7	1	183511445	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08	20761533	183511445	65739176	7	2340											
HMCN1	83872	broad.mit.edu	37	chr1	185972975	185972975	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttcattggttcaaagatggcAagtgagtatcttttctgtat	9	5	4	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:185972975A>T	uc001grq.1	+	29	4703	c.4474A>T	c.(4474-4476)AAG>TAG	p.K1492*		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1492	Ig-like C2-type 12.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAAAGATGGCAAGTGAGTATC	0.388													T	185972975	T	T	185972975	4	4	38	1	0	0	0	0	0	1	0	0	7220	144	5	5	4588	5	HMCN1	1	185972975	Nonsense_Mutation	SNP	A	TCGA-06-0185-01A-01W-0254-08	2461530	185972975	63277646	8	2341											
USH2A	7399	broad.mit.edu	37	chr1	216373084	216373084	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgtggtcactgtaatgggCaagctgtgtaaacagccccc	12	11	1	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:216373084C>T	uc001hku.1	-	17	4083	c.3696G>A	c.(3694-3696)TTG>TTA	p.L1232L	USH2A_uc001hkv.2_Silent_p.L1232L	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1232	Extracellular (Potential).|Fibronectin type-III 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGTAATGGGCAAGCTGTGTA	0.483										HNSCC(13;0.011)			T	216373084	T	T	216373084	2	4	38	1	0	0	0	0	0	0	0	1	17033	709	25	3		3	USH2A	1	216373084	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08	30400109	216373084	32877537	9	2342											
ZP4	57829	broad.mit.edu	37	chr1	238053434	238053434	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cttttcttatccaggtgccaCagtcggagtcattctgcagc	9	12	3	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:238053434C>G	uc001hym.2	-	2	218	c.218G>C	c.(217-219)TGT>TCT	p.C73S	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	73	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CCAGGTGCCACAGTCGGAGTC	0.562													G	238053434	G	G	238053434	3	3	38	1	0	0	0	0	1	0	0	0	18215	478	17	5	1448	5	ZP4	1	238053434	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	21680350	238053434	11197187	10	2343											
OR2W5	441932	broad.mit.edu	37	chr1	247654759	247654759	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacatgatgctgggctccacCgagtgcgtcctcctggttgt	12	12	0	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr1:247654759C>T	uc001icz.1	+	1	330	c.330C>T	c.(328-330)ACC>ACT	p.T110T		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T110T(1)		ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGGGCTCCACCGAGTGCGTCC	0.607													T	247654759	T	T	247654759	2	4	38	1	0	0	0	0	0	0	0	1	11034	639	23	2		2	OR2W5	1	247654759	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08	9601325	247654759	1595862	11	2344											
TCF23	150921	broad.mit.edu	37	chr2	27373157	27373157	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacatagcccacctcacccGcacactcggccacgagttgc	7	19	1	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr2:27373157G>A	uc010ylg.1	+	2	389	c.389G>A	c.(388-390)CGC>CAC	p.R130H		NM_175769	NP_786951	Q7RTU1	TCF23_HUMAN	transcription factor 23	130	Helix-loop-helix motif.				cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCTCACCCGCACACTCGGC	0.652													A	27373157	A	A	27373157	3	1	38	1	0	0	0	0	1	0	0	0	15689	1087	38	1	395	1	TCF23	2	27373157	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08		27373157	215826216	12	2345											
PLB1	151056	broad.mit.edu	37	chr2	28764631	28764631	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgagcaggagtccttcaccGtggttttccagcctttcttc	10	12	2	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr2:28764631G>A	uc002rmb.1	+	13	832	c.832G>A	c.(832-834)GTG>ATG	p.V278M	PLB1_uc010ezj.1_Missense_Mutation_p.V289M	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	278	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity	p.V278M(1)		ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					GTCCTTCACCGTGGTTTTCCA	0.537													A	28764631	A	A	28764631	3	1	38	1	0	0	0	0	1	0	0	0	12024	1145	40	1	915	1	PLB1	2	28764631	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	1391474	28764631	214434742	13	2346											
RAB11FIP5	26056	broad.mit.edu	37	chr2	73315522	73315544	+	Frame_Shift_Del	DEL	AGCACTCAGCTCCTCCTGTCCAA	-	-													ggggccaggactttagcctgAgcactcagctcctcctgtcc					rs138135562		TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr2:73315522_73315544delAGCACTCAGCTCCTCCTGTCCAA	uc002siu.3	-	3	1443_1465	c.1202_1224delTTGGACAGGAGGAGCTGAGTGCT	c.(1201-1224)CTTGGACAGGAGGAGCTGAGTGCTfs	p.L401fs	RAB11FIP5_uc002sit.3_Frame_Shift_Del_p.L323fs	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	401_408					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CTTTAGCCTGAGCACTCAGCTCCTCCTGTCCAAGCACTGCCTC	0.637													-	73315544	-	-	73315522	7	5	38	1	0	1	0	1	0	0	0	0	12897	291	11	0	749	0	RAB11FIP5	2	73315522	Frame_Shift_Del	DEL	AGCACTCAGCTCCTCCTGTCCAA	TCGA-06-0185-01A-01W-0254-08	44550891	73315522	169883851	14	2347											
TTN	7273	broad.mit.edu	37	chr2	179455353	179455353	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaggtggtttgatgggccGgcaagcttttattggatcag	14	7	1	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr2:179455353G>A	uc010zfg.1	-	253	53619	c.53395C>T	c.(53395-53397)CGG>TGG	p.R17799W	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R11494W|TTN_uc010zfi.1_Missense_Mutation_p.R11427W|TTN_uc010zfj.1_Missense_Mutation_p.R11302W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18726							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGATGGGCCGGCAAGCTTTT	0.433													A	179455353	A	A	179455353	3	1	38	1	0	0	0	0	1	0	0	0	16732	1115	39	2	47116	2	TTN	2	179455353	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	106139831	179455353	63744020	15	2348											
STAT1	6772	broad.mit.edu	37	chr2	191862974	191862974	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaagcattaaatacatcTtcttgagtaacagctgttct	6	8	4	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr2:191862974T>A	uc002usj.2	-	8	990	c.602A>T	c.(601-603)AAG>ATG	p.K201M	STAT1_uc010fse.1_Missense_Mutation_p.K201M|STAT1_uc002usk.2_Missense_Mutation_p.K201M|STAT1_uc002usl.2_Missense_Mutation_p.K203M|STAT1_uc010fsf.1_Intron	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	201					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity	p.K201M(1)		lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TAAATACATCTTCTTGAGTAA	0.338													A	191862974	A	A	191862974	3	1	38	1	0	0	0	0	1	0	0	0	15263	1609	56	5	1726	5	STAT1	2	191862974	Missense_Mutation	SNP	T	TCGA-06-0185-01A-01W-0254-08	12407621	191862974	51336399	16	2349											
COL6A3	1293	broad.mit.edu	37	chr2	238283533	238283533	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgctgtactgcaccacggcCacgcggacccggtcctggcc	12	18	0	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr2:238283533C>T	uc002vwl.2	-	8	3486	c.3201G>A	c.(3199-3201)GTG>GTA	p.V1067V	COL6A3_uc002vwo.2_Silent_p.V861V|COL6A3_uc010znj.1_Silent_p.V460V|COL6A3_uc002vwq.2_Silent_p.V861V|COL6A3_uc002vwr.2_Silent_p.V660V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1067	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCACCACGGCCACGCGGACCC	0.602													T	238283533	T	T	238283533	2	4	38	1	0	0	0	0	0	0	0	1	3701	581	21	3		3	COL6A3	2	238283533	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08	46420559	238283533	4915840	17	2350											
FBLN2	2199	broad.mit.edu	37	chr3	13679197	13679197	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgcattggccccgcgccagcCttcacgggggacaccatcgc	12	18	1	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr3:13679197C>A	uc011avb.1	+	17	3458	c.3333C>A	c.(3331-3333)GCC>GCA	p.A1111A	FBLN2_uc011auz.1_Silent_p.A1137A|FBLN2_uc011ava.1_Silent_p.A1158A|FBLN2_uc011avc.1_Silent_p.A1158A	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	1111	Domain III.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CCGCGCCAGCCTTCACGGGGG	0.622													A	13679197	A	A	13679197	2	1	38	1	0	0	0	0	0	0	0	1	5699	668	24	5		5	FBLN2	3	13679197	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08		13679197	184343233	18	2351											
C3orf67	200844	broad.mit.edu	37	chr3	58849423	58849423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tctttccatgaggtgctgatCgtggtcttgatgaaaaagtg	12	6	2	4			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr3:58849423C>T	uc003dkt.1	-	12	1488	c.1079G>A	c.(1078-1080)CGA>CAA	p.R360Q	C3orf67_uc003dks.1_Missense_Mutation_p.R175Q|uc003dku.1_Intron|C3orf67_uc003dkv.1_Missense_Mutation_p.R175Q|C3orf67_uc003dkw.2_Missense_Mutation_p.R255Q	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	360											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		AGGTGCTGATCGTGGTCTTGA	0.473													T	58849423	T	T	58849423	3	4	38	1	0	0	0	0	1	0	0	0	2241	884	31	2	632	2	C3orf67	3	58849423	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	45170226	58849423	139173007	19	2352											
IQCB1	9657	broad.mit.edu	37	chr3	121489274	121489274	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gaacatcaatctcatctccaGattcttctccaagcttcttc	3	14	6	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr3:121489274G>A	uc010hre.1	-	15	1930	c.1715C>T	c.(1714-1716)TCT>TTT	p.S572F	IQCB1_uc003eek.2_Missense_Mutation_p.S439F|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	572					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		CTCATCTCCAGATTCTTCTCC	0.448													A	121489274	A	A	121489274	3	1	38	1	0	0	0	0	1	0	0	0	7803	942	33	3	85	3	IQCB1	3	121489274	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	62639851	121489274	76533156	20	2353											
AMOTL2	51421	broad.mit.edu	37	chr3	134080563	134080563	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagagcctgctccagcagctCggcacgccgccgctggtcct	12	18	0	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr3:134080563C>T	uc003eqf.2	-	6	1657	c.1540G>A	c.(1540-1542)GAG>AAG	p.E514K	AMOTL2_uc003eqg.1_Missense_Mutation_p.E456K|AMOTL2_uc003eqh.1_Missense_Mutation_p.E456K|AMOTL2_uc003eqe.1_Missense_Mutation_p.E81K	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	456	Potential.									large_intestine(1)	1						TCCAGCAGCTCGGCACGCCGC	0.652													T	134080563	T	T	134080563	3	4	38	1	0	0	0	0	1	0	0	0	584	893	31	2	996	2	AMOTL2	3	134080563	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	12591289	134080563	63941867	21	2354											
EPHB1	2047	broad.mit.edu	37	chr3	134920443	134920443	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctaggaacattctggtcaAcagtaacctggtgtgcaagg	12	8	2	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr3:134920443A>G	uc003eqt.2	+	12	2478	c.2258A>G	c.(2257-2259)AAC>AGC	p.N753S	EPHB1_uc003equ.2_Missense_Mutation_p.N314S	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	753	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.N753S(1)|p.N753N(1)		lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						ATTCTGGTCAACAGTAACCTG	0.552													G	134920443	G	G	134920443	3	3	38	1	0	0	0	0	1	0	0	0	5174	43	2	4	2304	4	EPHB1	3	134920443	Missense_Mutation	SNP	A	TCGA-06-0185-01A-01W-0254-08	839880	134920443	63101987	22	2355											
TRIM59	286827	broad.mit.edu	37	chr3	160156161	160156161	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aatttcaacgggttgaacctCaggaagtggtctttgtttca	10	7	4	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr3:160156161C>T	uc003fdm.2	-	3	1006	c.811G>A	c.(811-813)GAG>AAG	p.E271K	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	271						integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGTTGAACCTCAGGAAGTGGT	0.363													T	160156161	T	T	160156161	3	4	38	1	0	0	0	0	1	0	0	0	16529	835	29	3	404	3	TRIM59	3	160156161	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	25235718	160156161	37866269	23	2356											
SPATA5	166378	broad.mit.edu	37	chr4	123868606	123868606	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaaatagtgctcatggataCgttggagcagacttgaaagt	12	6	1	2	rs139834687	byFrequency	TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr4:123868606C>T	uc003iez.3	+	9	1750	c.1677C>T	c.(1675-1677)TAC>TAT	p.Y559Y	SPATA5_uc003iey.2_Silent_p.Y558Y	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	559					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						CTCATGGATACGTTGGAGCAG	0.468													T	123868606	T	T	123868606	2	4	38	1	0	0	0	0	0	0	0	1	15010	547	19	1		1	SPATA5	4	123868606	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08		123868606	67285670	24	2357											
PHF17	79960	broad.mit.edu	37	chr4	129770286	129770286	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcaatgacatggatgctgcaTggctggaactgaccaatgaa	11	8	1	3			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr4:129770286T>A	uc003igk.2	+	5	728	c.448T>A	c.(448-450)TGG>AGG	p.W150R	PHF17_uc003igj.2_Missense_Mutation_p.W150R|PHF17_uc003igl.2_Missense_Mutation_p.W138R|PHF17_uc011cgy.1_Missense_Mutation_p.W150R|PHF17_uc003igm.2_Missense_Mutation_p.W150R	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	150					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						GGATGCTGCATGGCTGGAACT	0.468													A	129770286	A	A	129770286	3	1	38	1	0	0	0	0	1	0	0	0	11828	1464	51	5	462	5	PHF17	4	129770286	Missense_Mutation	SNP	T	TCGA-06-0185-01A-01W-0254-08	5901680	129770286	61383990	25	2358											
FNIP2	57600	broad.mit.edu	37	chr4	159789510	159789510	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggtcattacggtgaggaaCgagcccgctcttgtaccccc	12	13	2	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr4:159789510C>T	uc003iqe.3	+	13	1905	c.1722C>T	c.(1720-1722)AAC>AAT	p.N574N		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	574	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CGGTGAGGAACGAGCCCGCTC	0.537													T	159789510	T	T	159789510	2	4	38	1	0	0	0	0	0	0	0	1	5976	535	19	1		1	FNIP2	4	159789510	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08	30019224	159789510	31364766	26	2359											
HEATR7B2	133558	broad.mit.edu	37	chr5	41052628	41052628	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatcaatggccatccttccCgagcttcaatataggacttt	6	12	2	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr5:41052628C>T	uc003jmj.3	-	12	1659	c.1169G>A	c.(1168-1170)CGG>CAG	p.R390Q	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	390							binding			ovary(6)|central_nervous_system(2)	8						CCATCCTTCCCGAGCTTCAAT	0.393													T	41052628	T	T	41052628	3	4	38	1	0	0	0	0	1	0	0	0	7035	652	23	2	3712	2	HEATR7B2	5	41052628	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08		41052628	139862632	27	2360											
TRPC7	57113	broad.mit.edu	37	chr5	135692669	135692669	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcgggctgagcgtcaggCgctggccctgcgcgaaggcc	17	15	1	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr5:135692669C>T	uc003lbn.1	-	1	407	c.404G>A	c.(403-405)CGC>CAC	p.R135H	TRPC7_uc010jef.1_Missense_Mutation_p.R127H|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.R127H|TRPC7_uc010jei.1_Missense_Mutation_p.R127H|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	136	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GAGCGTCAGGCGCTGGCCCTG	0.672													T	135692669	T	T	135692669	3	4	38	1	0	0	0	0	1	0	0	0	16581	768	27	1	2225	1	TRPC7	5	135692669	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	94640041	135692669	45222591	28	2361											
UNC5A	90249	broad.mit.edu	37	chr5	176304269	176304269	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctcacgctgcacaagccGgaagacgtgaggtgtggccg	14	12	1	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr5:176304269G>A	uc003mey.2	+	9	1647	c.1455G>A	c.(1453-1455)CCG>CCA	p.P485P		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	485	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGCACAAGCCGGAAGACGTGA	0.652													A	176304269	A	A	176304269	2	1	38	1	0	0	0	0	0	0	0	1	16988	1103	39	2		2	UNC5A	5	176304269	Silent	SNP	G	TCGA-06-0185-01A-01W-0254-08	40611600	176304269	4610991	29	2362											
ATXN1	6310	broad.mit.edu	37	chr6	16306892	16306892	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttgagtgcttcagcaggaCgctggcgggatccacgggct	15	11	1	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr6:16306892C>T	uc003nbt.2	-	9	3087	c.2116G>A	c.(2116-2118)GTC>ATC	p.V706I	ATXN1_uc010jpi.2_Missense_Mutation_p.V706I|ATXN1_uc010jpj.1_RNA	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	706	Interaction with USP7.|RNA-binding.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				TTCAGCAGGACGCTGGCGGGA	0.582													T	16306892	T	T	16306892	3	4	38	1	0	0	0	0	1	0	0	0	1209	536	19	1	335	1	ATXN1	6	16306892	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08		16306892	154808175	30	2363											
MICB	4277	broad.mit.edu	37	chr6	31474865	31474865	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcaccgtgacatgcagggCttccagcttctatccccgga	9	15	2	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr6:31474865C>T	uc003ntn.3	+	4	796	c.680C>T	c.(679-681)GCT>GTT	p.A227V	MICB_uc011dnm.1_Missense_Mutation_p.A195V|MICB_uc003nto.3_Missense_Mutation_p.A184V	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	227	Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						ACATGCAGGGCTTCCAGCTTC	0.587													T	31474865	T	T	31474865	3	4	38	1	0	0	0	0	1	0	0	0	9575	797	28	3	694	3	MICB	6	31474865	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	15167973	31474865	139640202	31	2364											
KATNA1	11104	broad.mit.edu	37	chr6	149918283	149918283	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caacatcatcagccaattccAactcacgtagacttattcgt	4	13	3	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr6:149918283A>C	uc003qmr.1	-	9	1238	c.1193T>G	c.(1192-1194)TTG>TGG	p.L398W	KATNA1_uc003qms.2_Missense_Mutation_p.L398W|KATNA1_uc003qmt.2_Intron	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	398					cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		AGCCAATTCCAACTCACGTAG	0.388													C	149918283	C	C	149918283	3	2	38	1	0	0	0	0	1	0	0	0	7984	131	5	5	290	5	KATNA1	6	149918283	Missense_Mutation	SNP	A	TCGA-06-0185-01A-01W-0254-08	118443418	149918283	21196784	32	2365											
SYTL3	94120	broad.mit.edu	37	chr6	159178400	159178400	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagtccttccgctggcatcCgctccgggccaaggtgatgt	12	14	0	1	rs147104644		TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr6:159178400C>T	uc003qrp.2	+	13	1539	c.1295C>T	c.(1294-1296)CCG>CTG	p.P432L	SYTL3_uc011efp.1_Missense_Mutation_p.P432L|SYTL3_uc003qro.2_Missense_Mutation_p.P364L|SYTL3_uc003qrq.2_Missense_Mutation_p.P364L|SYTL3_uc003qrr.2_Missense_Mutation_p.P432L|SYTL3_uc003qrs.2_Missense_Mutation_p.P364L|SYTL3_uc011efq.1_Missense_Mutation_p.P158L	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	432					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		CGCTGGCATCCGCTCCGGGCC	0.527													T	159178400	T	T	159178400	3	4	38	1	0	0	0	0	1	0	0	0	15481	652	23	2	1125	2	SYTL3	6	159178400	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	9260117	159178400	11936667	33	2366											
MLLT4	4301	broad.mit.edu	37	chr6	168363130	168363130	+	Silent	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tagttgcaggacgaggagcgGaggcggcagcagcagttaga	18	7	0	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr6:168363130G>C	uc003qwd.2	+	31	5002	c.4860G>C	c.(4858-4860)CGG>CGC	p.R1620R	MLLT4_uc003qwc.1_Silent_p.R1608R|MLLT4_uc003qwg.1_Silent_p.R919R	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1610	Potential.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		ACGAGGAGCGGAGGCGGCAGC	0.537			T	MLL	AL								C	168363130	C	C	168363130	2	2	38	1	0	0	0	0	0	0	0	1	9629	1161	41	5		5	MLLT4	6	168363130	Silent	SNP	G	TCGA-06-0185-01A-01W-0254-08	9184730	168363130	2751937	34	2367											
MLLT4	4301	broad.mit.edu	37	chr6	168363191	168363191	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cggaagaccgagcgaggcaaGaggaagagcgccggcggcag	19	10	0	3			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr6:168363191G>C	uc003qwd.2	+	31	5063	c.4921G>C	c.(4921-4923)GAG>CAG	p.E1641Q	MLLT4_uc003qwc.1_Missense_Mutation_p.E1629Q|MLLT4_uc003qwg.1_Missense_Mutation_p.E940Q	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1631	Potential.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		AGCGAGGCAAGAGGAAGAGCG	0.542			T	MLL	AL								C	168363191	C	C	168363191	3	2	38	1	0	0	0	0	1	0	0	0	9629	943	33	5	5121	5	MLLT4	6	168363191	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	61	168363191	2751876	35	2368											
ABCB5	340273	broad.mit.edu	37	chr7	20689724	20689724	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatggcagtgggaagagtaCggtagtccagcttctgcaga	14	8	1	2	rs144527025	by1000genomes	TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr7:20689724C>T	uc003suw.3	+	3	497	c.-49C>T	c.(-51--47)TACGG>TATGG		ABCB5_uc010kuh.2_Missense_Mutation_p.T429M|ABCB5_uc003suv.3_Translation_Start_Site|ABCB5_uc011jyi.1_Translation_Start_Site	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5						regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						GGGAAGAGTACGGTAGTCCAG	0.468													T	20689724	T	T	20689724	1	4	38	1	0	0	0	0	0	0	0	0	44	536	19	1		1	ABCB5	7	20689724	Translation_Start_Site	SNP	C	TCGA-06-0185-01A-01W-0254-08		20689724	138448939	36	2369											
EGFR	1956	broad.mit.edu	37	chr7	55240707	55240707	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtccatcgccactgggatgGtgggggccctcctcttgctg	14	14	1	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr7:55240707G>A	uc003tqk.2	+	17	2197	c.1951G>A	c.(1951-1953)GTG>ATG	p.V651M	EGFR_uc010kzg.1_Missense_Mutation_p.V606M|EGFR_uc011kco.1_Missense_Mutation_p.V598M	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	651	Helical; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V651M(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CACTGGGATGGTGGGGGCCCT	0.622		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55240707	A	A	55240707	3	1	38	1	0	0	0	0	1	0	0	0	4967	1261	44	3	2281	3	EGFR	7	55240707	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	34550983	55240707	103897956	37	2370											
SEPT14	346288	broad.mit.edu	37	chr7	55874788	55874788	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aatatttttactcacctaacTggctggttgtttggacccac	7	10	1	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr7:55874788T>A	uc003tqz.2	-	8	1098	c.981A>T	c.(979-981)CCA>CCT	p.P327P		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	327					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTCACCTAACTGGCTGGTTGT	0.348													A	55874788	A	A	55874788	2	1	38	1	0	0	0	0	0	0	0	1	14063	1567	55	5		5	SEPT14	7	55874788	Silent	SNP	T	TCGA-06-0185-01A-01W-0254-08	634081	55874788	103263875	38	2371											
DYNC1I1	1780	broad.mit.edu	37	chr7	95499217	95499217	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagactgcataaactgggcGtgtcaaaggtcacccaagtg	12	9	2	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr7:95499217G>A	uc003uoc.3	+	6	725	c.448G>A	c.(448-450)GTG>ATG	p.V150M	DYNC1I1_uc003uod.3_Missense_Mutation_p.V133M|DYNC1I1_uc003uob.2_Missense_Mutation_p.V113M|DYNC1I1_uc003uoe.3_Missense_Mutation_p.V130M|DYNC1I1_uc010lfl.2_Missense_Mutation_p.V139M	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	150					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TAAACTGGGCGTGTCAAAGGT	0.453													A	95499217	A	A	95499217	3	1	38	1	0	0	0	0	1	0	0	0	4842	1145	40	1	466	1	DYNC1I1	7	95499217	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	39624429	95499217	63639446	39	2372											
RABL5	64792	broad.mit.edu	37	chr7	100959700	100959700	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgtgtgtcctgtaaggaCggctgttggacaaagcagga	14	8	0	0	rs145991606	byFrequency	TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr7:100959700C>T	uc003uyl.2	-	4	433	c.330G>A	c.(328-330)CCG>CCA	p.P110P	RABL5_uc011kkk.1_Silent_p.P33P|RABL5_uc011kkl.1_Silent_p.P33P|RABL5_uc003uym.2_Silent_p.P80P|RABL5_uc010lhw.2_RNA|RABL5_uc011kkm.1_Silent_p.P110P	NM_022777	NP_073614	Q9H7X7	RABL5_HUMAN	RAB, member RAS oncogene family-like 5 isoform	110							GTP binding				0	Lung NSC(181;0.215)					CCTGTAAGGACGGCTGTTGGA	0.473													T	100959700	T	T	100959700	2	4	38	1	0	0	0	0	0	0	0	1	12973	523	19	1		1	RABL5	7	100959700	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08	5460483	100959700	58178963	40	2373											
LAMB4	22798	broad.mit.edu	37	chr7	107671256	107671256	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtagaactaatgaccttctCaagactcccagcctggtgtt	9	11	1	3			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr7:107671256C>T	uc010ljo.1	-	32	5071	c.4987G>A	c.(4987-4989)GAG>AAG	p.E1663K	LAMB4_uc003vey.2_Missense_Mutation_p.E1663K|LAMB4_uc010ljp.1_Missense_Mutation_p.E632K	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1663	Potential.|Domain I.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						ATGACCTTCTCAAGACTCCCA	0.473													T	107671256	T	T	107671256	3	4	38	1	0	0	0	0	1	0	0	0	8613	835	29	3	310	3	LAMB4	7	107671256	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	6711556	107671256	51467407	41	2374											
BRAF	673	broad.mit.edu	37	chr7	140453148	140453148	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagatttcactgtagctagaCcaaaatcacctatttttact	5	9	2	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr7:140453148C>T	uc003vwc.3	-	15	1848	c.1787G>A	c.(1786-1788)GGT>GAT	p.G596D		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	596	Protein kinase.		G -> R (in a colorectal adenocarcinoma sample; somatic mutation).|G -> V (in CFC syndrome).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G596R(4)|p.G596D(2)|p.G596fs*2(1)|p.D594_T599del(1)|p.G596S(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TGTAGCTAGACCAAAATCACC	0.388		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				T	140453148	T	T	140453148	3	4	38	1	0	0	0	0	1	0	0	0	1496	507	18	3	529	3	BRAF	7	140453148	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	32781892	140453148	18685515	42	2375											
ADAM9	8754	broad.mit.edu	37	chr8	38873654	38873654	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagaatcattgtcattatcgGggctatgtggagggagttca	13	5	3	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr8:38873654G>A	uc003xmr.2	+	5	429	c.351G>A	c.(349-351)CGG>CGA	p.R117R	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	117	Extracellular (Potential).			Missing (in Ref. 2; no nucleotide entry).|R -> Q (in Ref. 4; BAA03499).	activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			GTCATTATCGGGGCTATGTGG	0.338													A	38873654	A	A	38873654	2	1	38	1	0	0	0	0	0	0	0	1	253	1219	43	3		3	ADAM9	8	38873654	Silent	SNP	G	TCGA-06-0185-01A-01W-0254-08		38873654	107490368	43	2376											
RP1	6101	broad.mit.edu	37	chr8	55539225	55539225	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaacataaatccatatccaaCtttaaagcctataaaatcag	3	9	1	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr8:55539225C>A	uc003xsd.1	+	4	2931	c.2783C>A	c.(2782-2784)ACT>AAT	p.T928N	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	928					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCATATCCAACTTTAAAGCCT	0.328													A	55539225	A	A	55539225	3	1	38	1	0	0	0	0	1	0	0	0	13532	565	20	5	2793	5	RP1	8	55539225	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	16665571	55539225	90824797	44	2377											
RALYL	138046	broad.mit.edu	37	chr8	85774590	85774590	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagtaattccgctgaagcGtcccagagtggcagtcacaa	11	11	1	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr8:85774590G>A	uc003ycq.3	+	7	889	c.473G>A	c.(472-474)CGT>CAT	p.R158H	RALYL_uc003ycr.3_Missense_Mutation_p.R158H|RALYL_uc003ycs.3_Missense_Mutation_p.R158H|RALYL_uc010lzy.2_Missense_Mutation_p.R147H|RALYL_uc003yct.3_Missense_Mutation_p.R171H|RALYL_uc003ycu.3_Missense_Mutation_p.R85H|RALYL_uc003ycv.3_Missense_Mutation_p.R70H	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	158							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						CCGCTGAAGCGTCCCAGAGTG	0.507													A	85774590	A	A	85774590	3	1	38	1	0	0	0	0	1	0	0	0	13020	1145	40	1	534	1	RALYL	8	85774590	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	30235365	85774590	60589432	45	2378											
COL22A1	169044	broad.mit.edu	37	chr8	139856384	139856384	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgatctccttctacacgaaCgctaggacagagcacatctg	9	13	3	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr8:139856384C>T	uc003yvd.2	-	4	1123	c.676G>A	c.(676-678)GTT>ATT	p.V226I		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	226					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCTACACGAACGCTAGGACAG	0.463										HNSCC(7;0.00092)			T	139856384	T	T	139856384	3	4	38	1	0	0	0	0	1	0	0	0	3681	536	19	1	4452	1	COL22A1	8	139856384	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	54081794	139856384	6507638	46	2379											
C9orf131	138724	broad.mit.edu	37	chr9	35043416	35043416	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cccatactatggaagatctaGaagggatggcccccgatcct	10	12	1	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr9:35043416G>A	uc003zvw.2	+	2	819	c.790G>A	c.(790-792)GAA>AAA	p.E264K	C9orf131_uc003zvu.2_Missense_Mutation_p.E216K|C9orf131_uc003zvv.2_Missense_Mutation_p.E191K|C9orf131_uc003zvx.2_Missense_Mutation_p.E229K	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	264											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			GGAAGATCTAGAAGGGATGGC	0.547													A	35043416	A	A	35043416	3	1	38	1	0	0	0	0	1	0	0	0	2457	943	33	3	812	3	C9orf131	9	35043416	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08		35043416	106170015	47	2380											
C9orf131	138724	broad.mit.edu	37	chr9	35043985	35043985	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ccagcatctgagacaccatgGaagggcatgcaaagtagaga	12	9	1	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr9:35043985G>C	uc003zvw.2	+	2	1388	c.1359G>C	c.(1357-1359)TGG>TGC	p.W453C	C9orf131_uc003zvu.2_Missense_Mutation_p.W405C|C9orf131_uc003zvv.2_Missense_Mutation_p.W380C|C9orf131_uc003zvx.2_Missense_Mutation_p.W418C	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	453											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			AGACACCATGGAAGGGCATGC	0.542													C	35043985	C	C	35043985	3	2	38	1	0	0	0	0	1	0	0	0	2457	1183	41	5	1381	5	C9orf131	9	35043985	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	569	35043985	106169446	48	2381											
RUSC2	9853	broad.mit.edu	37	chr9	35548294	35548294	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccactggatgagggcacttgCtgtagccatagcctgccacc	11	14	0	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr9:35548294C>A	uc003zww.2	+	2	2031	c.1776C>A	c.(1774-1776)TGC>TGA	p.C592*	RUSC2_uc010mkq.2_Intron|RUSC2_uc003zwx.3_Nonsense_Mutation_p.C592*	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	592						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			AGGGCACTTGCTGTAGCCATA	0.637													A	35548294	A	A	35548294	4	1	38	1	0	0	0	0	0	1	0	0	13751	805	28	5	1778	5	RUSC2	9	35548294	Nonsense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	504309	35548294	105665137	49	2382											
EXOSC3	51010	broad.mit.edu	37	chr9	37785036	37785036	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gccgcgacagacgcaggttcGgccatcgcgggctccaccaa	13	16	0	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr9:37785036G>T	uc004aal.2	-	1	32	c.6C>A	c.(4-6)GCC>GCA	p.A2A	EXOSC3_uc010mly.1_Silent_p.A2A|EXOSC3_uc004aam.2_Silent_p.A2A	NM_016042	NP_057126	Q9NQT5	EXOS3_HUMAN	exosome component 3 isoform 1	2					CUT catabolic process|DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|isotype switching|rRNA processing	cytoplasmic exosome (RNase complex)|cytosol|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding			breast(2)	2				GBM - Glioblastoma multiforme(29;0.00771)|Lung(182;0.221)		ACGCAGGTTCGGCCATCGCGG	0.662													T	37785036	T	T	37785036	2	4	38	1	0	0	0	0	0	0	0	1	5316	1103	39	5		5	EXOSC3	9	37785036	Silent	SNP	G	TCGA-06-0185-01A-01W-0254-08	2236742	37785036	103428395	50	2383											
OR13F1	138805	broad.mit.edu	37	chr9	107266629	107266629	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttcaggtcatcatatttgCggtgtgcttgctgatgtacc	11	8	3	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr9:107266629C>T	uc011lvm.1	+	1	86	c.86C>T	c.(85-87)GCG>GTG	p.A29V		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						ATCATATTTGCGGTGTGCTTG	0.418													T	107266629	T	T	107266629	3	4	38	1	0	0	0	0	1	0	0	0	10941	768	27	1	88	1	OR13F1	9	107266629	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	69481593	107266629	33946802	51	2384											
MUC5B	727897	broad.mit.edu	37	chr11	1267649	1267649	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacggtgcccaccggatccaCggccaccgcctcctccaccc	9	22	0	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr11:1267649C>T	uc009ycr.1	+	49	11414	c.11288C>T	c.(11287-11289)ACG>ATG	p.T3763M	MUC5B_uc001ltb.2_Missense_Mutation_p.T3183M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3180	7 X Cys-rich subdomain repeats.|Thr-rich.|17 X approximate tandem repeats, Ser/Thr- rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACCGGATCCACGGCCACCGCC	0.687													T	1267649	T	T	1267649	3	4	38	1	0	0	0	0	1	0	0	0	9979	536	19	1	9670	1	MUC5B	11	1267649	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08		1267649	133738867	52	2385											
LRRC55	219527	broad.mit.edu	37	chr11	56949722	56949722	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctcagcctggcccacaacCgcatcacagcagtgccgcct	8	19	2	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr11:56949722C>T	uc001njl.1	+	1	502	c.355C>T	c.(355-357)CGC>TGC	p.R119C		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	89	LRR 1.					integral to membrane					0						GGCCCACAACCGCATCACAGC	0.597													T	56949722	T	T	56949722	3	4	38	1	0	0	0	0	1	0	0	0	9011	652	23	2	357	2	LRRC55	11	56949722	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	55682073	56949722	78056794	53	2386											
AHNAK	79026	broad.mit.edu	37	chr11	62301253	62301253	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgtcggagaggctgccccCgagcccgagggcagtctgat	15	14	1	2	rs141489091	byFrequency	TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr11:62301253C>T	uc001ntl.2	-	5	936	c.636G>A	c.(634-636)TCG>TCA	p.S212S	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	212					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGGCTGCCCCCGAGCCCGAGG	0.562													T	62301253	T	T	62301253	2	4	38	1	0	0	0	0	0	0	0	1	414	639	23	2		2	AHNAK	11	62301253	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08	5351531	62301253	72705263	54	2387											
SNX15	29907	broad.mit.edu	37	chr11	64800008	64800008	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggagttccctgctttccccCgggcccaggtgtttggtgag	14	12	0	1	rs142024969	byFrequency	TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr11:64800008C>T	uc001oci.3	+	6	894	c.241C>T	c.(241-243)CGG>TGG	p.R81W	SNX15_uc009ypy.2_Missense_Mutation_p.R81W|SNX15_uc001ocj.2_Missense_Mutation_p.R81W|SNX15_uc001ock.2_Missense_Mutation_p.R81W	NM_013306	NP_037438	Q9NRS6	SNX15_HUMAN	sorting nexin 15 isoform A	81	PX.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			ovary(1)	1						TGCTTTCCCCCGGGCCCAGGT	0.627													T	64800008	T	T	64800008	3	4	38	1	0	0	0	0	1	0	0	0	14886	643	23	2	251	2	SNX15	11	64800008	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	2498755	64800008	70206508	55	2388											
HSPB2	3316	broad.mit.edu	37	chr11	111784541	111784541	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cgacatttggacacagaggtCaatgaggtctacatctccct	9	11	3	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr11:111784541C>T	uc001pmg.2	+	2	565	c.471C>T	c.(469-471)GTC>GTT	p.V157V	CRYAB_uc001pmf.1_5'Flank|CRYAB_uc010rwp.1_5'Flank|HSPB2_uc009yyj.2_RNA|C11orf52_uc001pmh.2_Intron	NM_001541	NP_001532	Q16082	HSPB2_HUMAN	heat shock 27kDa protein 2	157					response to heat|response to unfolded protein	cytosol|nucleus	enzyme activator activity|protein binding			ovary(2)|skin(1)	3		all_cancers(61;3.75e-11)|all_epithelial(67;2.33e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		ACACAGAGGTCAATGAGGTCT	0.592													T	111784541	T	T	111784541	2	4	38	1	0	0	0	0	0	0	0	1	7420	813	29	3		3	HSPB2	11	111784541	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08	46984533	111784541	23221975	56	2389											
PDZD3	79849	broad.mit.edu	37	chr11	119059718	119059718	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccccacaacaccaggtgaCtccaggaggctcagctgccc	10	18	1	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr11:119059718C>T	uc001pwb.2	+	8	2014	c.1490C>T	c.(1489-1491)ACT>ATT	p.T497I	PDZD3_uc001pvy.2_Missense_Mutation_p.T417I|PDZD3_uc001pvz.2_Missense_Mutation_p.T431I|PDZD3_uc010rzd.1_Missense_Mutation_p.T418I|PDZD3_uc001pwa.2_Missense_Mutation_p.T127I			Q86UT5	NHRF4_HUMAN	RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF4;          Short=NHERF-4; AltName: Full=PDZ domain-containing protein 3; AltName: Full=PDZ domain-containing protein 2; AltName: Full=Intestinal and kidney-enriched PDZ protein; AltName: Full=Sodium-hydrogen exchanger regulatory factor 4;	497	PDZ 4.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)	1	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		CACCAGGTGACTCCAGGAGGC	0.602													T	119059718	T	T	119059718	3	4	38	1	0	0	0	0	1	0	0	0	11702	565	20	3	1330	3	PDZD3	11	119059718	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	7275177	119059718	15946798	57	2390											
VSIG2	23584	broad.mit.edu	37	chr11	124620786	124620786	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctttgacttagaaccagttGgatacagatggccattggtg	12	7	0	3			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr11:124620786G>A	uc001qas.2	-	3	327	c.251C>T	c.(250-252)CCA>CTA	p.P84L	VSIG2_uc001qat.2_Missense_Mutation_p.P84L	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	84	Extracellular (Potential).|Ig-like V-type.					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		AGAACCAGTTGGATACAGATG	0.537													A	124620786	A	A	124620786	3	1	38	1	0	0	0	0	1	0	0	0	17221	1348	47	3	752	3	VSIG2	11	124620786	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	5561068	124620786	10385730	58	2391											
SLC6A13	6540	broad.mit.edu	37	chr12	333649	333649	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggcagcatcaccacagccCgcgggtaagcgatgaaagcc	13	13	1	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr12:333649C>T	uc001qic.1	-	10	1144	c.1091G>A	c.(1090-1092)CGG>CAG	p.R364Q	SLC6A13_uc009zdj.1_Missense_Mutation_p.R354Q|SLC6A13_uc010sdl.1_Missense_Mutation_p.R272Q	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	364					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CACCACAGCCCGCGGGTAAGC	0.617													T	333649	T	T	333649	3	4	38	1	0	0	0	0	1	0	0	0	14676	652	23	2	741	2	SLC6A13	12	333649	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08		333649	133518246	59	2392											
TMTC1	83857	broad.mit.edu	37	chr12	29786150	29786150	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaagatggtggctaagttcCgcatgtcccatatggtctct	11	9	1	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr12:29786150C>T	uc001rjb.2	-	6	1208	c.734G>A	c.(733-735)CGG>CAG	p.R245Q	TMTC1_uc001riz.2_Missense_Mutation_p.R2Q|TMTC1_uc001rja.2_Missense_Mutation_p.R89Q|TMTC1_uc001rjc.1_Missense_Mutation_p.R307Q	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	353						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GGCTAAGTTCCGCATGTCCCA	0.498													T	29786150	T	T	29786150	3	4	38	1	0	0	0	0	1	0	0	0	16257	652	23	2	1642	2	TMTC1	12	29786150	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	29452501	29786150	104065745	60	2393											
ARHGAP9	64333	broad.mit.edu	37	chr12	57872982	57872982	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gatgggtcgagaggtggaggGagcttctaggcgtcttgcca	18	7	2	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr12:57872982G>A	uc001sod.2	-	5	614	c.421C>T	c.(421-423)CCC>TCC	p.P141S	ARHGAP9_uc001snz.2_5'Flank|ARHGAP9_uc001soa.2_5'Flank|ARHGAP9_uc001sob.2_Missense_Mutation_p.P70S|ARHGAP9_uc001soc.2_Missense_Mutation_p.P70S|ARHGAP9_uc001soe.1_Missense_Mutation_p.P149S|ARHGAP9_uc010sro.1_Missense_Mutation_p.P70S	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	70	SH3.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			GAGGTGGAGGGAGCTTCTAGG	0.567													A	57872982	A	A	57872982	3	1	38	1	0	0	0	0	1	0	0	0	889	1174	41	3	2055	3	ARHGAP9	12	57872982	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	28086832	57872982	75978913	61	2394											
NTN4	59277	broad.mit.edu	37	chr12	96180812	96180812	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caggccaaatgtagcggagcAgttagtcgcaaagtacttat	11	8	0	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr12:96180812A>G	uc001tei.2	-	2	939	c.490T>C	c.(490-492)TGC>CGC	p.C164R	NTN4_uc009ztf.2_Missense_Mutation_p.C164R|NTN4_uc009ztg.2_Missense_Mutation_p.C127R	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	164	Laminin N-terminal.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						GTAGCGGAGCAGTTAGTCGCA	0.493													G	96180812	G	G	96180812	3	3	38	1	0	0	0	0	1	0	0	0	10702	188	7	4	1432	4	NTN4	12	96180812	Missense_Mutation	SNP	A	TCGA-06-0185-01A-01W-0254-08	38307830	96180812	37671083	62	2395											
UNC119B	84747	broad.mit.edu	37	chr12	121154526	121154526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccggcatttctccgcctcCggacagtcggggctacgtga	12	15	1	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr12:121154526C>T	uc001tyz.2	+	3	901	c.454C>T	c.(454-456)CGG>TGG	p.R152W		NM_001080533	NP_001074002	A6NIH7	U119B_HUMAN	unc-119 homolog B	152										haematopoietic_and_lymphoid_tissue(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCTCCGCCTCCGGACAGTCGG	0.532													T	121154526	T	T	121154526	3	4	38	1	0	0	0	0	1	0	0	0	16980	643	23	2	464	2	UNC119B	12	121154526	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	24973714	121154526	12697369	63	2396											
KBTBD6	89890	broad.mit.edu	37	chr13	41705381	41705381	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccatgccctcacgacacaGcaagcgatctgcaagttgct	8	14	2	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr13:41705381G>A	uc001uxu.1	-	1	1556	c.1267C>T	c.(1267-1269)CTG>TTG	p.L423L	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Silent_p.L357L|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	423	Kelch 1.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		TCACGACACAGCAAGCGATCT	0.493													A	41705381	A	A	41705381	2	1	38	1	0	0	0	0	0	0	0	1	7997	962	34	3		3	KBTBD6	13	41705381	Silent	SNP	G	TCGA-06-0185-01A-01W-0254-08		41705381	73464497	64	2397											
C15orf52	388115	broad.mit.edu	37	chr15	40630791	40630791	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggggggcttcgggtcacaCgccctccaggtgacccctct	14	15	2	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr15:40630791C>T	uc001zlh.3	-	5	606	c.590G>A	c.(589-591)CGT>CAT	p.R197H	C15orf52_uc001zli.1_Missense_Mutation_p.R129H|C15orf52_uc010ucn.1_5'Flank	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	197										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		TCGGGTCACACGCCCTCCAGG	0.577											OREG0023060	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	40630791	T	T	40630791	3	4	38	1	0	0	0	0	1	0	0	0	1800	536	19	1	1042	1	C15orf52	15	40630791	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08		40630791	61900601	65	2398											
TP53BP1	7158	broad.mit.edu	37	chr15	43773221	43773221	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccactgacattcccagaacaCtacacagcagaaggatataa	6	12	0	3			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr15:43773221C>G	uc001zrs.2	-	5	505	c.357_splice	c.e5-1	p.S119_splice	TP53BP1_uc010udp.1_Splice_Site_p.S119_splice|TP53BP1_uc001zrq.3_Splice_Site_p.S124_splice|TP53BP1_uc001zrr.3_Splice_Site_p.S124_splice|TP53BP1_uc010udq.1_Splice_Site_p.S124_splice	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3						double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TCCCAGAACACTACACAGCAG	0.333								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					G	43773221	G	G	43773221	5	3	38	1	0	0	0	0	0	0	1	0	16380	579	20	5	5658	5	TP53BP1	15	43773221	Splice_Site	SNP	C	TCGA-06-0185-01A-01W-0254-08	3142430	43773221	58758171	66	2399											
GCOM1	145781	broad.mit.edu	37	chr15	58006757	58006757	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcaagcaaagctcgcagcGcaaaaattagctgaaagact	9	9	0	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr15:58006757G>A	uc002aeo.2	+	13	1447	c.1328G>A	c.(1327-1329)CGC>CAC	p.R443H	GCOM1_uc002aem.2_Silent_p.A511A|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA|GRINL1A_uc002aes.2_Silent_p.A98A|GRINL1A_uc010ugu.1_RNA|GRINL1A_uc002aet.3_Silent_p.A329A|GRINL1A_uc002aeu.3_Silent_p.A172A	NM_001018091	NP_001018101	P0CAP1	GCOM1_HUMAN	GRINL1A combined protein isoform 2	51					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						AGCTCGCAGCGCAAAAATTAG	0.398													A	58006757	A	A	58006757	3	1	38	1	0	0	0	0	1	0	0	0	6304	1087	38	1	1688	1	GCOM1	15	58006757	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	14233536	58006757	44524635	67	2400											
ZSCAN10	84891	broad.mit.edu	37	chr16	3140535	3140535	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactgggcgcaaggctctccCggcaccccaggactatctgc	12	16	2	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr16:3140535C>T	uc002ctv.1	-	5	823	c.735G>A	c.(733-735)CCG>CCA	p.P245P	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Silent_p.P163P|ZSCAN10_uc002ctx.1_Silent_p.P173P	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	245					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AAGGCTCTCCCGGCACCCCAG	0.602													T	3140535	T	T	3140535	2	4	38	1	0	0	0	0	0	0	0	1	18224	639	23	2		2	ZSCAN10	16	3140535	Silent	SNP	C	TCGA-06-0185-01A-01W-0254-08		3140535	87214218	68	2401											
MYH11	4629	broad.mit.edu	37	chr16	15818586	15818586	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctggtcttgcaggctgttcCgctcctcctccagctggcgc	12	16	1	0	rs150883363		TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr16:15818586C>T	uc002ddy.2	-	30	4141	c.4034G>A	c.(4033-4035)CGG>CAG	p.R1345Q	MYH11_uc002ddv.2_Missense_Mutation_p.R1352Q|MYH11_uc002ddw.2_Missense_Mutation_p.R1345Q|MYH11_uc002ddx.2_Missense_Mutation_p.R1352Q|MYH11_uc010bvg.2_Missense_Mutation_p.R1177Q|NDE1_uc010uzy.1_3'UTR|NDE1_uc002dds.2_3'UTR|MYH11_uc010bvh.2_Missense_Mutation_p.R51Q|NDE1_uc002ddz.1_RNA	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1345	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CAGGCTGTTCCGCTCCTCCTC	0.597			T	CBFB	AML								T	15818586	T	T	15818586	3	4	38	1	0	0	0	0	1	0	0	0	10031	652	23	2	1967	2	MYH11	16	15818586	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	12678051	15818586	74536167	69	2402											
PRKCB	5579	broad.mit.edu	37	chr16	24231309	24231309	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agagagacacctccaacttcGacaaagagttcaccagacag	8	12	1	4			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr16:24231309G>A	uc002dmd.2	+	17	2088	c.1891G>A	c.(1891-1893)GAC>AAC	p.D631N	PRKCB_uc002dme.2_3'UTR	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	631	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CTCCAACTTCGACAAAGAGTT	0.433													A	24231309	A	A	24231309	3	1	38	1	0	0	0	0	1	0	0	0	12508	1058	37	2	2120	2	PRKCB	16	24231309	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	8412723	24231309	66123444	70	2403											
CHD9	80205	broad.mit.edu	37	chr16	53337775	53337775	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aacgcttgaagctttgccatCcaaatccagatttaccagtc	6	12	0	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr16:53337775C>T	uc002ehb.2	+	30	6021	c.5857C>T	c.(5857-5859)CCA>TCA	p.P1953S	CHD9_uc002egy.2_Missense_Mutation_p.P1953S|CHD9_uc002ehc.2_Missense_Mutation_p.P1953S|CHD9_uc002ehf.2_Missense_Mutation_p.P1067S|CHD9_uc010cbw.2_Intron|CHD9_uc002ehg.1_5'UTR	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1953					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GCTTTGCCATCCAAATCCAGA	0.478													T	53337775	T	T	53337775	3	4	38	1	0	0	0	0	1	0	0	0	3332	855	30	3	5975	3	CHD9	16	53337775	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	29106466	53337775	37016978	71	2404											
ASGR2	433	broad.mit.edu	37	chr17	7005462	7005462	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	catttccaagagccatcactGtccgtgagacctatccaggt	8	13	1	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr17:7005462G>T	uc002gep.3	-	8	982	c.717C>A	c.(715-717)GAC>GAA	p.D239E	ASGR2_uc010vtk.1_Missense_Mutation_p.D76E|ASGR2_uc002gem.1_Missense_Mutation_p.D178E|ASGR2_uc002gen.1_Missense_Mutation_p.D220E|ASGR2_uc002geo.1_Missense_Mutation_p.D234E|ASGR2_uc002ger.3_Missense_Mutation_p.D239E|ASGR2_uc002geq.3_Missense_Mutation_p.D215E	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	239	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	AGCCATCACTGTCCGTGAGAC	0.458													T	7005462	T	T	7005462	3	4	38	1	0	0	0	0	1	0	0	0	1040	1368	48	5	226	5	ASGR2	17	7005462	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08		7005462	74189748	72	2405											
KIF19	124602	broad.mit.edu	37	chr17	72346919	72346919	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggagtgctacgctaaggacGacagcgagaaggactcagac	14	9	1	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr17:72346919G>A	uc002jkm.3	+	12	1600	c.1462G>A	c.(1462-1464)GAC>AAC	p.D488N	KIF19_uc002jkj.2_Missense_Mutation_p.D488N|KIF19_uc002jkk.2_Missense_Mutation_p.D446N|KIF19_uc002jkl.2_Missense_Mutation_p.D446N	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	488					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						CGCTAAGGACGACAGCGAGAA	0.637													A	72346919	A	A	72346919	3	1	38	1	0	0	0	0	1	0	0	0	8282	1058	37	2	1508	2	KIF19	17	72346919	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	65341457	72346919	8848291	73	2406											
DSG3	1830	broad.mit.edu	37	chr18	29056162	29056162	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcaacctagctggcccaaCgcagctacgagggtcacata	11	13	1	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr18:29056162C>T	uc002kws.2	+	16	3048	c.2939C>T	c.(2938-2940)ACG>ATG	p.T980M	DSG3_uc002kwt.2_Missense_Mutation_p.T262M	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	980	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCTGGCCCAACGCAGCTACGA	0.488													T	29056162	T	T	29056162	3	4	38	1	0	0	0	0	1	0	0	0	4778	536	19	1	3001	1	DSG3	18	29056162	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08		29056162	49021086	74	2407											
ZBTB7C	201501	broad.mit.edu	37	chr18	45567452	45567452	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggttggggaagggaatgccAatgagctcatcaatgtcatt	13	6	3	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr18:45567452A>G	uc002lda.2	-	1	43	c.27T>C	c.(25-27)ATT>ATC	p.I9I	ZBTB7C_uc002ldb.2_Silent_p.I9I|ZBTB7C_uc010dnu.2_Silent_p.I18I|ZBTB7C_uc010dnv.2_Silent_p.I31I|ZBTB7C_uc010dnw.2_Silent_p.I9I|ZBTB7C_uc010dnx.1_Silent_p.I9I|ZBTB7C_uc010dny.1_Silent_p.I9I|ZBTB7C_uc010dnz.1_Silent_p.I31I|ZBTB7C_uc010dob.1_Silent_p.I9I|ZBTB7C_uc010doc.1_Silent_p.I18I|ZBTB7C_uc010dod.1_Silent_p.I31I|ZBTB7C_uc010doe.1_Silent_p.I9I|ZBTB7C_uc010dof.1_Silent_p.I9I|ZBTB7C_uc010dog.1_Silent_p.I9I|ZBTB7C_uc010doh.1_Silent_p.I18I|ZBTB7C_uc010doi.1_Silent_p.I9I|ZBTB7C_uc010doj.1_Silent_p.I18I|ZBTB7C_uc010dok.1_Silent_p.I58I|ZBTB7C_uc010dol.1_Silent_p.I18I|ZBTB7C_uc010doa.1_Silent_p.I31I|ZBTB7C_uc010don.1_Silent_p.I17I|ZBTB7C_uc010doo.1_Silent_p.I9I|ZBTB7C_uc010dop.1_Silent_p.I9I|ZBTB7C_uc010doq.1_Silent_p.I18I|ZBTB7C_uc010dor.1_Silent_p.I31I|ZBTB7C_uc010dos.1_Silent_p.I9I|ZBTB7C_uc010dot.1_Silent_p.I9I|ZBTB7C_uc010dou.1_Silent_p.I18I|ZBTB7C_uc010dom.1_Silent_p.I18I	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	9						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AGGGAATGCCAATGAGCTCAT	0.582													G	45567452	G	G	45567452	2	3	38	1	0	0	0	0	0	0	0	1	17552	126	5	4		4	ZBTB7C	18	45567452	Silent	SNP	A	TCGA-06-0185-01A-01W-0254-08	16511290	45567452	32509796	75	2408											
CHAF1A	10036	broad.mit.edu	37	chr19	4409752	4409752	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccacctccacgcccctccGcagagtgagtatctcccatg	7	20	1	2	rs112018734		TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr19:4409752G>A	uc002mal.2	+	3	1056	c.956G>A	c.(955-957)CGC>CAC	p.R319H		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	319					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCCCCTCCGCAGAGTGAGT	0.627								Chromatin_Structure					A	4409752	A	A	4409752	3	1	38	1	0	0	0	0	1	0	0	0	3311	1087	38	1	966	1	CHAF1A	19	4409752	Missense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08		4409752	54719231	76	2409											
PAPL	390928	broad.mit.edu	37	chr19	39589268	39589268	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctacatacaccgagtcacgCttcgcaagctgctgccaggg	10	14	2	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr19:39589268C>T	uc002oki.2	+	3	566	c.292C>T	c.(292-294)CTT>TTT	p.L98F	PAPL_uc010egl.2_Missense_Mutation_p.L98F	NM_001004318	NP_001004318	Q6ZNF0	PAPL_HUMAN	iron/zinc purple acid phosphatase-like protein	98						extracellular region	acid phosphatase activity|metal ion binding				0						CCGAGTCACGCTTCGCAAGCT	0.647													T	39589268	T	T	39589268	3	4	38	1	0	0	0	0	1	0	0	0	11427	797	28	3	298	3	PAPL	19	39589268	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	35179516	39589268	19539715	77	2410											
PSG9	5678	broad.mit.edu	37	chr19	43766068	43766068	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cactcactgggttccgtattTcacattcatagggtcctgca	8	12	3	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr19:43766068T>C	uc002owd.3	-	3	752	c.653A>G	c.(652-654)GAA>GGA	p.E218G	PSG9_uc002owe.3_Missense_Mutation_p.E218G|PSG9_uc010xwm.1_Intron|PSG9_uc002owf.3_Intron|PSG9_uc002owg.2_Missense_Mutation_p.E218G|PSG9_uc002owh.2_Intron	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	218	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				GTTCCGTATTTCACATTCATA	0.512													C	43766068	C	C	43766068	3	2	38	1	0	0	0	0	1	0	0	0	12662	1783	62	4	643	4	PSG9	19	43766068	Missense_Mutation	SNP	T	TCGA-06-0185-01A-01W-0254-08	4176800	43766068	15362915	78	2411											
NLRP5	126206	broad.mit.edu	37	chr19	56539799	56539799	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagcactgtccgtatttgCggaaaattcgggtggatgtc	12	9	0	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr19:56539799C>T	uc002qmj.2	+	7	2200	c.2200C>T	c.(2200-2202)CGG>TGG	p.R734W	NLRP5_uc002qmi.2_Missense_Mutation_p.R715W	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	734	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCCGTATTTGCGGAAAATTCG	0.502													T	56539799	T	T	56539799	3	4	38	1	0	0	0	0	1	0	0	0	10480	759	27	1	2226	1	NLRP5	19	56539799	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	12773731	56539799	2589184	79	2412											
LBP	3929	broad.mit.edu	37	chr20	36989406	36989406	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cctccgatctacagccttatCtccaaactctgccaggtagg	7	15	3	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr20:36989406C>T	uc002xic.1	+	6	672	c.637C>T	c.(637-639)CTC>TTC	p.L213F		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	213					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				ACAGCCTTATCTCCAAACTCT	0.418													T	36989406	T	T	36989406	3	4	38	1	0	0	0	0	1	0	0	0	8651	913	32	3	659	3	LBP	20	36989406	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08		36989406	26036114	80	2413											
SEMG1	6406	broad.mit.edu	37	chr20	43836503	43836503	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaaaaggtagaaaacaaggcGgatcccaaagcagttatgtt	10	6	0	1	rs113377758	byFrequency	TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr20:43836503G>T	uc002xni.2	+	2	622	c.565G>T	c.(565-567)GGA>TGA	p.G189*	SEMG1_uc002xnj.2_Nonsense_Mutation_p.G189*|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Nonsense_Mutation_p.G189*	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	189	42 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				AAAACAAGGCGGATCCCAAAG	0.388													T	43836503	T	T	43836503	4	4	38	1	0	0	0	0	0	1	0	0	14044	1117	39	5	571	5	SEMG1	20	43836503	Nonsense_Mutation	SNP	G	TCGA-06-0185-01A-01W-0254-08	6847097	43836503	19189017	81	2414											
ZNF831	128611	broad.mit.edu	37	chr20	57769723	57769723	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actttcctggtagcagcctcCgagatgagggtcccaatggc	12	12	0	2			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr20:57769723C>T	uc002yan.2	+	1	3649	c.3649C>T	c.(3649-3651)CGA>TGA	p.R1217*		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1217						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TAGCAGCCTCCGAGATGAGGG	0.627													T	57769723	T	T	57769723	4	4	38	1	0	0	0	0	0	1	0	0	18182	644	23	2	3651	2	ZNF831	20	57769723	Nonsense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	13933220	57769723	5255797	82	2415											
PKNOX1	5316	broad.mit.edu	37	chr21	44437070	44437070	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctcagggaattgtggtgcCggcgtccgcgctgcagcagg	16	13	1	0			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr21:44437070C>T	uc002zcq.1	+	6	763	c.575C>T	c.(574-576)CCG>CTG	p.P192L	PKNOX1_uc002zcp.1_Missense_Mutation_p.P192L|PKNOX1_uc011aex.1_Missense_Mutation_p.P75L|PKNOX1_uc002zcr.2_Missense_Mutation_p.P192L	NM_004571	NP_004562	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	192							sequence-specific DNA binding			large_intestine(2)	2						ATTGTGGTGCCGGCGTCCGCG	0.502													T	44437070	T	T	44437070	3	4	38	1	0	0	0	0	1	0	0	0	11982	652	23	2	593	2	PKNOX1	21	44437070	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08		44437070	3692825	83	2416											
C21orf56	84221	broad.mit.edu	37	chr21	47588353	47588353	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagtgagtcttgcaaggggCtcaggagcggggacagcttc	16	10	2	1			TCGA-06-0185-01A-01W-0254-08	TCGA-06-0185-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc62d57d-b536-41ab-a344-e765fd3f7439	7ffaca28-e3d7-4ef6-953f-4c7cb1e4d8b5	g.chr21:47588353C>T	uc011afu.1	-	3	1475	c.413G>A	c.(412-414)AGC>AAC	p.S138N	C21orf56_uc002zii.2_5'UTR	NM_001142854	NP_001136326	Q9H0A9	CU056_HUMAN	hypothetical protein LOC84221 isoform 1	138							protein binding			skin(1)	1	Breast(49;0.214)			Colorectal(79;0.241)		TTGCAAGGGGCTCAGGAGCGG	0.652													T	47588353	T	T	47588353	3	4	38	1	0	0	0	0	1	0	0	0	2127	797	28	3	621	3	C21orf56	21	47588353	Missense_Mutation	SNP	C	TCGA-06-0185-01A-01W-0254-08	3151283	47588353	541542	84	2417											
SLC45A1	50651	broad.mit.edu	37	chr1	8390537	8390537	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggcgacagcctcccgtcGcacacggccaccaacttctc	8	20	1	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr1:8390537G>A	uc001apb.2	+	4	984	c.984G>A	c.(982-984)TCG>TCA	p.S328S	SLC45A1_uc001apc.2_Silent_p.S26S	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	328					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GCCTCCCGTCGCACACGGCCA	0.697													A	8390537	A	A	8390537	2	1	39	1	0	0	0	0	0	0	0	1	14640	1074	38	1		1	SLC45A1	1	8390537	Silent	SNP	G	TCGA-06-0188-01A-01W-0254-08		8390537	240860084	1	2418											
KLHDC7A	127707	broad.mit.edu	37	chr1	18809465	18809465	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgggccggccccaccgggGgcagcaaggaccgcacggcc	18	16	0	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr1:18809465G>A	uc001bax.2	+	1	2042	c.1990G>A	c.(1990-1992)GGC>AGC	p.G664S	KLHDC7A_uc009vpg.2_Missense_Mutation_p.G446S	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	664	Kelch 5.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCACCGGGGGCAGCAAGGA	0.682													A	18809465	A	A	18809465	3	1	39	1	0	0	0	0	1	0	0	0	8360	1232	43	3	1992	3	KLHDC7A	1	18809465	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	10418928	18809465	230441156	2	2419											
FAM54B	56181	broad.mit.edu	37	chr1	26156090	26156090	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggatcctcattccactctaCaacttcctttgtcattagtg	5	12	3	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr1:26156090C>T	uc001bkq.3	+	6	752	c.542C>T	c.(541-543)ACA>ATA	p.T181I	FAM54B_uc001bkr.3_Intron|FAM54B_uc010oet.1_Missense_Mutation_p.T214I|FAM54B_uc009vrz.2_Missense_Mutation_p.T166I|FAM54B_uc001bks.3_Missense_Mutation_p.T181I|FAM54B_uc001bkt.3_Missense_Mutation_p.T181I|FAM54B_uc001bku.3_Intron|FAM54B_uc001bkv.3_Missense_Mutation_p.T84I	NM_001099625	NP_001093095	Q9H019	FA54B_HUMAN	hypothetical protein LOC56181 isoform a	181										pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.96e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.00095)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCACTCTACAACTTCCTTT	0.478													T	26156090	T	T	26156090	3	4	39	1	0	0	0	0	1	0	0	0	5583	478	17	3	560	3	FAM54B	1	26156090	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	7346625	26156090	223094531	3	2420											
CYB5RL	606495	broad.mit.edu	37	chr1	54653374	54653374	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgttggcagggctgatgggcGtataggctctctgaatttct	14	8	2	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr1:54653374G>A	uc009vzo.2	-	5	706	c.386C>T	c.(385-387)ACG>ATG	p.T129M	CYB5RL_uc001cww.2_Translation_Start_Site|CYB5RL_uc001cwx.3_RNA|CYB5RL_uc001cwy.3_Translation_Start_Site	NM_001031672	NP_001026842	Q6IPT4	NB5R5_HUMAN	cytochrome b5 reductase-like	129	FAD-binding FR-type.						cytochrome-b5 reductase activity				0						GCTGATGGGCGTATAGGCTCT	0.448													A	54653374	A	A	54653374	3	1	39	1	0	0	0	0	1	0	0	0	4130	1145	40	1	577	1	CYB5RL	1	54653374	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	28497284	54653374	194597247	4	2421											
RYR2	6262	broad.mit.edu	37	chr1	237608770	237608770	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatcccagcatgaagaatcaCgcacagcccgagttatccgg	10	13	1	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr1:237608770C>T	uc001hyl.1	+	14	1360	c.1240C>T	c.(1240-1242)CGC>TGC	p.R414C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	414	Cytoplasmic (By similarity).		R -> L (in CPVT1).		cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGAAGAATCACGCACAGCCCG	0.393													T	237608770	T	T	237608770	3	4	39	1	0	0	0	0	1	0	0	0	13769	536	19	1	1294	1	RYR2	1	237608770	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	182955396	237608770	11641851	5	2422											
SLC5A7	60482	broad.mit.edu	37	chr2	108626770	108626770	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacagccatggccttgctgaCgaaaactgtgtatgggctct	11	10	1	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr2:108626770C>T	uc002tdv.2	+	9	1472	c.1196C>T	c.(1195-1197)ACG>ATG	p.T399M	SLC5A7_uc010ywm.1_Missense_Mutation_p.T152M|SLC5A7_uc010fjj.2_Missense_Mutation_p.T399M|SLC5A7_uc010ywn.1_Missense_Mutation_p.T286M	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	399	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GCCTTGCTGACGAAAACTGTG	0.463													T	108626770	T	T	108626770	3	4	39	1	0	0	0	0	1	0	0	0	14670	536	19	1	1226	1	SLC5A7	2	108626770	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08		108626770	134572603	6	2423											
LRP2	4036	broad.mit.edu	37	chr2	170007505	170007505	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagtttagccacctcaatgcGtttattcttgacatctgacc	6	11	3	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr2:170007505G>A	uc002ues.2	-	68	12706	c.12493C>T	c.(12493-12495)CGC>TGC	p.R4165C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4165	Extracellular (Potential).|LDL-receptor class B 35.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACCTCAATGCGTTTATTCTTG	0.428													A	170007505	A	A	170007505	3	1	39	1	0	0	0	0	1	0	0	0	8956	1145	40	1	1522	1	LRP2	2	170007505	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	61380735	170007505	73191868	7	2424											
TTN	7273	broad.mit.edu	37	chr2	179498764	179498764	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaagttgctgtttcaccttcTtttactgtttgatcttcaag	6	8	4	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr2:179498764T>C	uc010zfg.1	-	180	34982	c.34758A>G	c.(34756-34758)AAA>AAG	p.K11586K	TTN_uc010zfh.1_Silent_p.K5281K|TTN_uc010zfi.1_Silent_p.K5214K|TTN_uc010zfj.1_Silent_p.K5089K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12513							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCACCTTCTTTTACTGTTT	0.358													C	179498764	C	C	179498764	2	2	39	1	0	0	0	0	0	0	0	1	16732	1606	56	4		4	TTN	2	179498764	Silent	SNP	T	TCGA-06-0188-01A-01W-0254-08	9491259	179498764	63700609	8	2425											
DNAJC10	54431	broad.mit.edu	37	chr2	183584858	183584858	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acttgaggataatcaaggtgGccagtatgaaagctggaact	12	6	1	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr2:183584858G>A	uc002uow.1	+	4	744	c.329G>A	c.(328-330)GGC>GAC	p.G110D	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Missense_Mutation_p.G110D|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	110					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			AATCAAGGTGGCCAGTATGAA	0.308													A	183584858	A	A	183584858	3	1	39	1	0	0	0	0	1	0	0	0	4629	1203	42	3	335	3	DNAJC10	2	183584858	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	4086094	183584858	59614515	9	2426											
TNS1	7145	broad.mit.edu	37	chr2	218712554	218712554	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaggggttcccaacgaatGcccactggggatatagccag	12	12	1	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr2:218712554G>A	uc002vgt.2	-	17	2709	c.2311C>T	c.(2311-2313)CAT>TAT	p.H771Y	TNS1_uc002vgr.2_Missense_Mutation_p.H771Y|TNS1_uc002vgs.2_Missense_Mutation_p.H771Y|TNS1_uc010zjv.1_Missense_Mutation_p.H771Y|TNS1_uc010fvj.1_Missense_Mutation_p.H839Y|TNS1_uc010fvk.1_Missense_Mutation_p.H896Y|TNS1_uc010fvi.1_Missense_Mutation_p.H458Y	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	771						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CCCAACGAATGCCCACTGGGG	0.607													A	218712554	A	A	218712554	3	1	39	1	0	0	0	0	1	0	0	0	16340	1319	46	3	2964	3	TNS1	2	218712554	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	35127696	218712554	24486819	10	2427											
ABCB6	10058	broad.mit.edu	37	chr2	220080773	220080773	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgcgatccgcagcacctccCctgtgcggcgccccaggtgc	12	20	0	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr2:220080773C>T	uc002vkc.1	-	5	1377	c.1100G>A	c.(1099-1101)GGG>GAG	p.G367E	ABCB6_uc010fwe.1_Missense_Mutation_p.G321E|ABCB6_uc010zku.1_Intron	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	367	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGCACCTCCCCTGTGCGGCG	0.672													T	220080773	T	T	220080773	3	4	39	1	0	0	0	0	1	0	0	0	45	623	22	3	1488	3	ABCB6	2	220080773	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	1368219	220080773	23118600	11	2428											
KDR	3791	broad.mit.edu	37	chr4	55976857	55976857	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgggtaaccaaggtacttcGcagggattctgacacgctcc	12	11	1	1	rs151317075	byFrequency	TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr4:55976857G>A	uc003has.2	-	8	1357	c.1055C>T	c.(1054-1056)GCG>GTG	p.A352V	KDR_uc003hat.1_Missense_Mutation_p.A352V|KDR_uc011bzx.1_Missense_Mutation_p.A352V	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	352	Ig-like C2-type 4.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.A352V(1)		lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AAGGTACTTCGCAGGGATTCT	0.413			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			A	55976857	A	A	55976857	3	1	39	1	0	0	0	0	1	0	0	0	8139	1087	38	1	3107	1	KDR	4	55976857	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08		55976857	135177419	12	2429											
TMPRSS11A	339967	broad.mit.edu	37	chr4	68784698	68784698	+	Frame_Shift_Del	DEL	G	-	-													ctgagatacccaccaccataGtaaagtgctccaaatcctgt							TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr4:68784698delG	uc003hdr.1	-	8	1075	c.954delC	c.(952-954)TACfs	p.Y318fs	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Frame_Shift_Del_p.Y315fs	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	318	Peptidase S1.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						CACCACCATAGTAAAGTGCTC	0.453													-	68784698	-	-	68784698	7	5	39	1	0	1	0	1	0	0	0	0	16236	1024	36	0	323	0	TMPRSS11A	4	68784698	Frame_Shift_Del	DEL	G	TCGA-06-0188-01A-01W-0254-08	12807841	68784698	122369578	13	2430											
UGT2B11	10720	broad.mit.edu	37	chr4	70079996	70079996	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggaaaaacagcatctgcaaAaacgatgtcaaatcttgact	8	8	3	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr4:70079996A>G	uc003heh.2	-	1	454	c.445T>C	c.(445-447)TTT>CTT	p.F149L	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	149					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						GCATCTGCAAAAACGATGTCA	0.383													G	70079996	G	G	70079996	3	3	39	1	0	0	0	0	1	0	0	0	16954	14	1	4	1168	4	UGT2B11	4	70079996	Missense_Mutation	SNP	A	TCGA-06-0188-01A-01W-0254-08	1295298	70079996	121074280	14	2431											
UGT2B28	54490	broad.mit.edu	37	chr4	70156481	70156481	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	actggacttccacacaatgtCgagtacagacctgctgaatg	9	11	0	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr4:70156481C>T	uc003hej.2	+	5	1264	c.1262C>T	c.(1261-1263)TCG>TTG	p.S421L	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	421					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	CACACAATGTCGAGTACAGAC	0.423													T	70156481	T	T	70156481	3	4	39	1	0	0	0	0	1	0	0	0	16957	893	31	2	1280	2	UGT2B28	4	70156481	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	76485	70156481	120997795	15	2432											
TACR3	6870	broad.mit.edu	37	chr4	104511030	104511030	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catggactccattctggtcaCggtgtacatactgctttgcc	9	12	2	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr4:104511030C>T	uc003hxe.1	-	5	1350	c.1207G>A	c.(1207-1209)GTG>ATG	p.V403M		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	403	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		ATTCTGGTCACGGTGTACATA	0.498													T	104511030	T	T	104511030	3	4	39	1	0	0	0	0	1	0	0	0	15504	536	19	1	194	1	TACR3	4	104511030	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	34354549	104511030	86643246	16	2433											
C5orf33	133686	broad.mit.edu	37	chr5	36197710	36197710	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tattggttctcgaatactgaAaagtatttttggttcttccg	8	6	2	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr5:36197710A>T	uc003jkf.3	-	11	1123	c.1123T>A	c.(1123-1125)TTC>ATC	p.F375I	C5orf33_uc003jke.3_RNA|C5orf33_uc010iux.2_Missense_Mutation_p.F180I|C5orf33_uc003jkg.3_Missense_Mutation_p.F212I|C5orf33_uc011cov.1_Missense_Mutation_p.F234I	NM_001085411	NP_001078880	Q4G0N4	NAKD1_HUMAN	hypothetical protein LOC133686 isoform 1	375							NAD+ kinase activity				0	all_lung(31;5.63e-05)		Epithelial(62;0.0254)|all cancers(62;0.0805)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CGAATACTGAAAAGTATTTTT	0.353													T	36197710	T	T	36197710	3	4	39	1	0	0	0	0	1	0	0	0	2292	14	1	5	213	5	C5orf33	5	36197710	Missense_Mutation	SNP	A	TCGA-06-0188-01A-01W-0254-08		36197710	144717550	17	2434											
ADAMTS19	171019	broad.mit.edu	37	chr5	129037232	129037232	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaagcccgcctctgcccagCgctgtgagggccaggactgc	13	17	1	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr5:129037232C>T	uc003kvb.1	+	20	3088	c.3088C>T	c.(3088-3090)CGC>TGC	p.R1030C	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1030	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTCTGCCCAGCGCTGTGAGGG	0.592													T	129037232	T	T	129037232	3	4	39	1	0	0	0	0	1	0	0	0	264	768	27	1	3166	1	ADAMTS19	5	129037232	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	92839522	129037232	51878028	18	2435											
SLC22A5	6584	broad.mit.edu	37	chr5	131728210	131728210	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggtctacgtgtacacagcCgagctgtatcccacagtggt	11	11	1	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr5:131728210C>T	uc003kww.3	+	8	1617	c.1353C>T	c.(1351-1353)GCC>GCT	p.A451A	SLC22A5_uc003kwx.3_Silent_p.A475A|SLC22A5_uc010jdr.1_Silent_p.A71A	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5	451	Helical; Name=10; (Potential).				positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TGTACACAGCCGAGCTGTATC	0.532													T	131728210	T	T	131728210	2	4	39	1	0	0	0	0	0	0	0	1	14457	639	23	2		2	SLC22A5	5	131728210	Silent	SNP	C	TCGA-06-0188-01A-01W-0254-08	2690978	131728210	49187050	19	2436											
ZNF76	7629	broad.mit.edu	37	chr6	35255444	35255444	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggctatgaccccagcacccTggaagccgtccaactggaag	11	14	0	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr6:35255444T>C	uc003oki.1	+	5	459	c.254T>C	c.(253-255)CTG>CCG	p.L85P	ZNF76_uc011dsy.1_Missense_Mutation_p.L85P|ZNF76_uc011dsz.1_Missense_Mutation_p.L85P|ZNF76_uc003okj.1_Missense_Mutation_p.L85P|ZNF76_uc011dsx.1_Missense_Mutation_p.L85P	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	85	3 X 12 AA approximate repeats.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCCAGCACCCTGGAAGCCGTC	0.577													C	35255444	C	C	35255444	3	2	39	1	0	0	0	0	1	0	0	0	18132	1580	55	4	268	4	ZNF76	6	35255444	Missense_Mutation	SNP	T	TCGA-06-0188-01A-01W-0254-08		35255444	135859623	20	2437											
DAAM2	23500	broad.mit.edu	37	chr6	39864627	39864627	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagctggtccgcagcaagcGtcttagacagatgctagagg	15	9	1	3			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr6:39864627G>A	uc003oow.2	+	20	2537	c.2381G>A	c.(2380-2382)CGT>CAT	p.R794H	DAAM2_uc003oox.2_Missense_Mutation_p.R794H	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	794	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CGCAGCAAGCGTCTTAGACAG	0.612													A	39864627	A	A	39864627	3	1	39	1	0	0	0	0	1	0	0	0	4216	1145	40	1	2455	1	DAAM2	6	39864627	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	4609183	39864627	131250440	21	2438											
PRPH2	5961	broad.mit.edu	37	chr6	42672106	42672106	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gctggcccagggcctacctcGaagagccaaatgaggagcgt	14	12	0	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr6:42672106G>A	uc003osk.2	-	2	1111	c.825C>T	c.(823-825)TTC>TTT	p.F275F		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	275	Helical; (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			GGCCTACCTCGAAGAGCCAAA	0.627													A	42672106	A	A	42672106	2	1	39	1	0	0	0	0	0	0	0	1	12577	1049	37	2		2	PRPH2	6	42672106	Silent	SNP	G	TCGA-06-0188-01A-01W-0254-08	2807479	42672106	128442961	22	2439											
KHDRBS2	202559	broad.mit.edu	37	chr6	62995779	62995779	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctaccttctgccaaaaggcgCgacgcatgcacaaaagatgg	10	12	1	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr6:62995779C>T	uc003peg.2	-	1	322	c.75G>A	c.(73-75)TCG>TCA	p.S25S		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	25					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		CCAAAAGGCGCGACGCATGCA	0.567													T	62995779	T	T	62995779	2	4	39	1	0	0	0	0	0	0	0	1	8147	755	27	1		1	KHDRBS2	6	62995779	Silent	SNP	C	TCGA-06-0188-01A-01W-0254-08	20323673	62995779	108119288	23	2440											
SASH1	23328	broad.mit.edu	37	chr6	148840740	148840740	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggatgaacggtccgccctctActctggcgtgcacaagaagc	12	13	2	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr6:148840740A>G	uc003qme.1	+	10	1395	c.920A>G	c.(919-921)TAC>TGC	p.Y307C	SASH1_uc011eeb.1_Missense_Mutation_p.Y68C	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	307							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		TCCGCCCTCTACTCTGGCGTG	0.552													G	148840740	G	G	148840740	3	3	39	1	0	0	0	0	1	0	0	0	13848	391	14	4	958	4	SASH1	6	148840740	Missense_Mutation	SNP	A	TCGA-06-0188-01A-01W-0254-08	85844961	148840740	22274327	24	2441											
PKD1L1	168507	broad.mit.edu	37	chr7	47835588	47835588	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaagatctcacagcttacgTgattctcaaccatctcagcc	5	15	3	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr7:47835588T>C	uc003tny.1	-	55	8354	c.8354A>G	c.(8353-8355)CAC>CGC	p.H2785R	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2785	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ACAGCTTACGTGATTCTCAAC	0.413													C	47835588	C	C	47835588	3	2	39	1	0	0	0	0	1	0	0	0	11964	1710	59	4	207	4	PKD1L1	7	47835588	Missense_Mutation	SNP	T	TCGA-06-0188-01A-01W-0254-08		47835588	111303075	25	2442											
MLL3	58508	broad.mit.edu	37	chr7	151960173	151960173	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaagtatgataccctttgtcAcacgtatcacacactagcat	5	11	2	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr7:151960173A>G	uc003wla.2	-	9	1446	c.1227T>C	c.(1225-1227)TGT>TGC	p.C409C		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	409	PHD-type 2.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACCCTTTGTCACACGTATCAC	0.308			N		medulloblastoma								G	151960173	G	G	151960173	2	3	39	1	0	0	0	0	0	0	0	1	9622	157	6	4		4	MLL3	7	151960173	Silent	SNP	A	TCGA-06-0188-01A-01W-0254-08	104124585	151960173	7178490	26	2443											
RIMS2	9699	broad.mit.edu	37	chr8	105026843	105026843	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaagggaacgttggatagaAgtaagttttatttctaattg	10	3	1	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr8:105026843A>G	uc003yls.2	+	17	2795	c.2554A>G	c.(2554-2556)AAC>GAC	p.N852D	RIMS2_uc003ylp.2_Missense_Mutation_p.K1112E|RIMS2_uc003ylw.2_Missense_Mutation_p.N926D|RIMS2_uc003ylq.2_Missense_Mutation_p.K926E|RIMS2_uc003ylr.2_Missense_Mutation_p.K951E	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTTGGATAGAAGTAAGTTTTA	0.418										HNSCC(12;0.0054)			G	105026843	G	G	105026843	3	3	39	1	0	0	0	0	1	0	0	0	13368	86	3	4	3604	4	RIMS2	8	105026843	Missense_Mutation	SNP	A	TCGA-06-0188-01A-01W-0254-08		105026843	41337179	27	2444											
DPYS	1807	broad.mit.edu	37	chr8	105456494	105456494	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accatctctccttgcatccgCtatcaccttagctgcagact	5	16	2	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr8:105456494C>A	uc003yly.3	-	4	904	c.775G>T	c.(775-777)GCG>TCG	p.A259S		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	259					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTGCATCCGCTATCACCTTA	0.493													A	105456494	A	A	105456494	3	1	39	1	0	0	0	0	1	0	0	0	4746	797	28	5	808	5	DPYS	8	105456494	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	429651	105456494	40907528	28	2445											
COL14A1	7373	broad.mit.edu	37	chr8	121259908	121259908	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggaatggtataaccggttgCgcattacgtgggacccccca	12	11	0	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr8:121259908C>T	uc003yox.2	+	21	2801	c.2536C>T	c.(2536-2538)CGC>TGC	p.R846C	COL14A1_uc003yoy.2_Missense_Mutation_p.R524C	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	846	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TAACCGGTTGCGCATTACGTG	0.458													T	121259908	T	T	121259908	3	4	39	1	0	0	0	0	1	0	0	0	3671	768	27	1	2614	1	COL14A1	8	121259908	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	15803414	121259908	25104114	29	2446											
TG	7038	broad.mit.edu	37	chr8	133879299	133879299	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctccatctgctgggtgtcGgccaatatcttcggtaagtt	11	11	2	0	rs145163419	byFrequency	TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr8:133879299G>A	uc003ytw.2	+	1	95	c.54G>A	c.(52-54)TCG>TCA	p.S18S		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	18					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCTGGGTGTCGGCCAATATCT	0.483													A	133879299	A	A	133879299	2	1	39	1	0	0	0	0	0	0	0	1	15810	1103	39	2		2	TG	8	133879299	Silent	SNP	G	TCGA-06-0188-01A-01W-0254-08	12619391	133879299	12484723	30	2447											
PRUNE2	158471	broad.mit.edu	37	chr9	79469120	79469120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccttctccaagcgtttgcttCgattctgaaacaaattcaaa	5	11	3	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr9:79469120C>T	uc010mpk.2	-	2	165	c.41G>A	c.(40-42)CGA>CAA	p.R14Q	PRUNE2_uc004akn.2_Missense_Mutation_p.R14Q	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	14					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GCGTTTGCTTCGATTCTGAAA	0.323													T	79469120	T	T	79469120	3	4	39	1	0	0	0	0	1	0	0	0	12641	884	31	2	9297	2	PRUNE2	9	79469120	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08		79469120	61744311	31	2448											
AKNA	80709	broad.mit.edu	37	chr9	117129898	117129898	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactggtcctcagagatgtcCcggttctccggaagccaccc	11	15	2	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr9:117129898C>T	uc004biq.3	-	5	1788	c.1653G>A	c.(1651-1653)CGG>CGA	p.R551R	AKNA_uc004bio.3_Silent_p.R11R|AKNA_uc004bip.3_Silent_p.R470R|AKNA_uc004bir.3_Silent_p.R551R|AKNA_uc004bis.3_Silent_p.R551R|AKNA_uc010mve.2_Silent_p.R432R|AKNA_uc004biu.1_Silent_p.R292R|AKNA_uc004biv.1_Silent_p.R551R	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						CAGAGATGTCCCGGTTCTCCG	0.617													T	117129898	T	T	117129898	2	4	39	1	0	0	0	0	0	0	0	1	463	610	22	3		3	AKNA	9	117129898	Silent	SNP	C	TCGA-06-0188-01A-01W-0254-08	37660778	117129898	24083533	32	2449											
TNC	3371	broad.mit.edu	37	chr9	117797581	117797581	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggcagtttccgactgaacctCagtagcagtcaagtctcttg	10	11	3	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr9:117797581C>T	uc004bjj.3	-	22	6051	c.5689G>A	c.(5689-5691)GAG>AAG	p.E1897K	TNC_uc010mvf.2_Missense_Mutation_p.E1624K	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1897	Fibronectin type-III 15.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding	p.E1897K(1)		central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GACTGAACCTCAGTAGCAGTC	0.433													T	117797581	T	T	117797581	3	4	39	1	0	0	0	0	1	0	0	0	16267	835	29	3	944	3	TNC	9	117797581	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	667683	117797581	23415850	33	2450											
OR5C1	392391	broad.mit.edu	37	chr9	125551260	125551260	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggttgcccctgctgaattcGtcctcctgggcatcacaaat	9	14	1	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr9:125551260G>A	uc011lzd.1	+	1	49	c.49G>A	c.(49-51)GTC>ATC	p.V17I		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TGCTGAATTCGTCCTCCTGGG	0.587													A	125551260	A	A	125551260	3	1	39	1	0	0	0	0	1	0	0	0	11153	1145	40	1	51	1	OR5C1	9	125551260	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	7753679	125551260	15662171	34	2451											
PTEN	5728	broad.mit.edu	37	chr10	89720812	89720812	+	Frame_Shift_Del	DEL	A	-	-													tatctagtacttactttaacAaaaaatgatcttgacaaagc							TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr10:89720812delA	uc001kfb.2	+	9	1994	c.963delA	c.(961-963)ACAfs	p.T321fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	321	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.T321fs*23(9)|p.T321fs*3(7)|p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.N323fs*2(2)|p.T319_K332del(1)|p.T321fs*22(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.L316fs*1(1)|p.W274_F341del(1)|p.V317_K322del(1)|p.T321fs*4(1)|p.T321fs*6(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTACTTTAACAAAAAATGATC	0.323		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89720812	-	-	89720812	7	5	39	1	0	1	0	1	0	0	0	0	12738	117	5	0	993	0	PTEN	10	89720812	Frame_Shift_Del	DEL	A	TCGA-06-0188-01A-01W-0254-08		89720812	45813935	35	2452											
MMP26	56547	broad.mit.edu	37	chr11	5013297	5013297	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taccccacttactggtatcaCgaccctagaaccttccagct	5	16	1	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr11:5013297C>T	uc001lzv.2	+	5	717	c.699C>T	c.(697-699)CAC>CAT	p.H233H		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	233					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		ACTGGTATCACGACCCTAGAA	0.488													T	5013297	T	T	5013297	2	4	39	1	0	0	0	0	0	0	0	1	9663	535	19	1		1	MMP26	11	5013297	Silent	SNP	C	TCGA-06-0188-01A-01W-0254-08		5013297	129993219	36	2453											
OR52L1	338751	broad.mit.edu	37	chr11	6007615	6007615	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcttggcagaagataagtttTcccaacaaaatggggaaggg	13	6	0	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr11:6007615T>C	uc001mcd.2	-	1	601	c.546A>G	c.(544-546)GGA>GGG	p.G182G		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGATAAGTTTTCCCAACAAAA	0.488													C	6007615	C	C	6007615	2	2	39	1	0	0	0	0	0	0	0	1	11125	1770	62	4		4	OR52L1	11	6007615	Silent	SNP	T	TCGA-06-0188-01A-01W-0254-08	994318	6007615	128998901	37	2454											
MAP4K2	5871	broad.mit.edu	37	chr11	64568434	64568434	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agctcaatggcagtgatgccCagggcccagacgtcacatag	12	12	2	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr11:64568434C>G	uc001obh.2	-	9	692	c.600G>C	c.(598-600)CTG>CTC	p.L200L	MAP4K2_uc001obi.2_Silent_p.L200L	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	200	Protein kinase.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						CAGTGATGCCCAGGGCCCAGA	0.622													G	64568434	G	G	64568434	2	3	39	1	0	0	0	0	0	0	0	1	9260	581	21	5		5	MAP4K2	11	64568434	Silent	SNP	C	TCGA-06-0188-01A-01W-0254-08	58560819	64568434	70438082	38	2455											
PTPRB	5787	broad.mit.edu	37	chr12	70986066	70986066	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggagcccaagactcacatgtTctgcccactgccatcttctg	8	15	4	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr12:70986066T>G	uc001swb.3	-	5	1152	c.1122A>C	c.(1120-1122)AGA>AGC	p.R374S	PTPRB_uc010sto.1_Missense_Mutation_p.R374S|PTPRB_uc010stp.1_Missense_Mutation_p.R374S|PTPRB_uc001swc.3_Missense_Mutation_p.R592S|PTPRB_uc001swa.3_Missense_Mutation_p.R592S|PTPRB_uc001swd.3_Missense_Mutation_p.R591S|PTPRB_uc009zrr.1_Missense_Mutation_p.R471S|PTPRB_uc001swe.2_Missense_Mutation_p.R592S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	374	Fibronectin type-III 4.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACTCACATGTTCTGCCCACTG	0.448													G	70986066	G	G	70986066	3	3	39	1	0	0	0	0	1	0	0	0	12796	1780	62	5	4983	5	PTPRB	12	70986066	Missense_Mutation	SNP	T	TCGA-06-0188-01A-01W-0254-08		70986066	62865829	39	2456											
ACADS	35	broad.mit.edu	37	chr12	121176678	121176678	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcccggctgctgacctggcGcgctgccatgctgaaggata	14	13	0	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr12:121176678G>A	uc001tza.3	+	8	1107	c.989G>A	c.(988-990)CGC>CAC	p.R330H	ACADS_uc010szl.1_Missense_Mutation_p.R326H|ACADS_uc001tzb.3_Missense_Mutation_p.R211H	NM_000017	NP_000008	P16219	ACADS_HUMAN	short-chain acyl-CoA dehydrogenase precursor	330						mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(2)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	CTGACCTGGCGCGCTGCCATG	0.642													A	121176678	A	A	121176678	3	1	39	1	0	0	0	0	1	0	0	0	114	1087	38	1	1019	1	ACADS	12	121176678	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	50190612	121176678	12675217	40	2457											
RB1	5925	broad.mit.edu	37	chr13	48953730	48953730	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctttttgtttgtttgtagCgatacaaacttggagttcgc	9	6	1	0	rs3092891		TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr13:48953730C>T	uc001vcb.2	+	14	1499	c.1333C>T	c.(1333-1335)CGA>TGA	p.R445*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	445	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.R445*(2)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTTTGTAGCGATACAAACT	0.204		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	48953730	T	T	48953730	4	4	39	1	0	0	0	0	0	1	0	0	13098	782	27	1	1387	1	RB1	13	48953730	Nonsense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08		48953730	66216148	41	2458											
OR4K5	79317	broad.mit.edu	37	chr14	20389501	20389501	+	Frame_Shift_Del	DEL	G	-	-													cgctggcttcccatattgcaGtagtaatattattctttgga							TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr14:20389501delG	uc010tkw.1	+	1	736	c.736delG	c.(736-738)GTAfs	p.V246fs		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCATATTGCAGTAGTAATATT	0.398													-	20389501	-	-	20389501	7	5	39	1	0	1	0	1	0	0	0	0	11073	1029	36	0	738	0	OR4K5	14	20389501	Frame_Shift_Del	DEL	G	TCGA-06-0188-01A-01W-0254-08		20389501	86960039	42	2459											
GOLGA6D	653643	broad.mit.edu	37	chr15	75580661	75580661	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcatattcaagaattggagCgggctctctgtgctgtgtct	12	8	3	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr15:75580661C>T	uc010uma.1	+	7	555	c.520C>T	c.(520-522)CGG>TGG	p.R174W	uc010umb.1_5'Flank	NM_001145224	NP_001138696	P0CG33	GOG6D_HUMAN	golgi autoantigen, golgin subfamily a, 6D	174	Potential.										0						AGAATTGGAGCGGGCTCTCTG	0.552													T	75580661	T	T	75580661	3	4	39	1	0	0	0	0	1	0	0	0	6560	759	27	1	546	1	GOLGA6D	15	75580661	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08		75580661	26950731	43	2460											
DECR2	26063	broad.mit.edu	37	chr16	455001	455001	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ggcggctctgggattgggttCcggattgctgagattttcat	15	7	2	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr16:455001C>G	uc002chb.2	+	2	232	c.126C>G	c.(124-126)TTC>TTG	p.F42L	DECR2_uc002chc.2_5'UTR|DECR2_uc010bqv.2_5'UTR|DECR2_uc002chd.2_5'UTR|DECR2_uc002che.1_5'Flank	NM_020664	NP_065715	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2	42	NADP (By similarity).					peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding				0		Hepatocellular(16;0.00015)				GGATTGGGTTCCGGATTGCTG	0.517													G	455001	G	G	455001	3	3	39	1	0	0	0	0	1	0	0	0	4383	854	30	5	132	5	DECR2	16	455001	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08		455001	89899752	44	2461											
ITGAM	3684	broad.mit.edu	37	chr16	31284722	31284722	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atcaccaacggagcccgaaaGaatgcctttaagatcctagt	8	11	1	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr16:31284722G>A	uc002ebq.2	+	8	839	c.741G>A	c.(739-741)AAG>AAA	p.K247K	ITGAM_uc002ebr.2_Silent_p.K247K|ITGAM_uc010cam.1_5'Flank	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	247	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GAGCCCGAAAGAATGCCTTTA	0.453													A	31284722	A	A	31284722	2	1	39	1	0	0	0	0	0	0	0	1	7887	933	33	3		3	ITGAM	16	31284722	Silent	SNP	G	TCGA-06-0188-01A-01W-0254-08	30829721	31284722	59070031	45	2462											
ITGAM	3684	broad.mit.edu	37	chr16	31286937	31286937	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcgcatccaagccgcctcGtgatcacgtgttccaggtga	10	14	1	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr16:31286937G>A	uc002ebq.2	+	9	1024	c.926G>A	c.(925-927)CGT>CAT	p.R309H	ITGAM_uc002ebr.2_Missense_Mutation_p.R309H|ITGAM_uc010cam.1_Translation_Start_Site	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	309	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						AAGCCGCCTCGTGATCACGTG	0.512													A	31286937	A	A	31286937	3	1	39	1	0	0	0	0	1	0	0	0	7887	1145	40	1	960	1	ITGAM	16	31286937	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	2215	31286937	59067816	46	2463											
ATP2A3	489	broad.mit.edu	37	chr17	3850757	3850757	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atgactgaggtgcagcccagGgtctccacggacggcaggct	15	12	1	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr17:3850757G>T	uc002fxb.1	-	8	1174	c.1023C>A	c.(1021-1023)ACC>ACA	p.T341T	ATP2A3_uc002fwx.1_Silent_p.T341T|ATP2A3_uc002fwy.1_Silent_p.T341T|ATP2A3_uc002fwz.1_Silent_p.T341T|ATP2A3_uc002fxa.1_Silent_p.T341T|ATP2A3_uc002fxc.1_Silent_p.T341T|ATP2A3_uc002fxd.1_Silent_p.T341T	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	341	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		TGCAGCCCAGGGTCTCCACGG	0.647													T	3850757	T	T	3850757	2	4	39	1	0	0	0	0	0	0	0	1	1138	1219	43	5		5	ATP2A3	17	3850757	Silent	SNP	G	TCGA-06-0188-01A-01W-0254-08		3850757	77344453	47	2464											
TP53	7157	broad.mit.edu	37	chr17	7576926	7576927	+	Splice_Site	DNP	GC	AT	AT													agctggtgttgttgggcagtGctaggaaagaggcaaggaaa							TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr17:7576926_7576927GC>AT	uc002gim.2	-	9	1114	c.920_splice	c.e9-1	p.A307_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.A307_splice|TP53_uc010cne.1_5'UTR|TP53_uc010cnf.1_Splice_Site_p.A175_splice|TP53_uc010cng.1_Splice_Site_p.A175_splice|TP53_uc002gii.1_Splice_Site_p.A175_splice|TP53_uc010cnh.1_Splice_Site_p.A307_splice|TP53_uc010cni.1_Splice_Site_p.A307_splice|TP53_uc002gij.2_Splice_Site_p.A307_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(16)|p.0?(7)|p.A307fs*34(1)|p.L308fs*31(1)|p.A307V(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTGGGCAGTGCTAGGAAAGAG	0.49		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			AT	7576927	AT	AT	7576926	5	1	39	1	0	0	0	0	0	0	1	0	16378	1333	46	3	362	3	TP53	17	7576926	Splice_Site	DNP	GC	TCGA-06-0188-01A-01W-0254-08	3726169	7576926	73618284	48	2465											
MYH8	4626	broad.mit.edu	37	chr17	10315706	10315706	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcaaagatttcaaagccaGcaatgtccaagaccccgatg	7	12	2	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr17:10315706G>A	uc002gmm.2	-	14	1492	c.1397C>T	c.(1396-1398)GCT>GTT	p.A466V	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	466	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTCAAAGCCAGCAATGTCCAA	0.438									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				A	10315706	A	A	10315706	3	1	39	1	0	0	0	0	1	0	0	0	10041	971	34	3	4524	3	MYH8	17	10315706	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	2738780	10315706	70879504	49	2466											
ACSF2	80221	broad.mit.edu	37	chr17	48540562	48540562	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaccctctcccactacaacAttgtcaacaactccaacatt	1	18	2	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr17:48540562A>G	uc002iqu.2	+	7	942	c.838A>G	c.(838-840)ATT>GTT	p.I280V	ACSF2_uc010wml.1_Missense_Mutation_p.I237V|ACSF2_uc010wmm.1_Missense_Mutation_p.I305V|ACSF2_uc010wmn.1_Missense_Mutation_p.I267V|ACSF2_uc010wmo.1_Missense_Mutation_p.I120V	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	280					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CCACTACAACATTGTCAACAA	0.597													G	48540562	G	G	48540562	3	3	39	1	0	0	0	0	1	0	0	0	175	217	8	4	864	4	ACSF2	17	48540562	Missense_Mutation	SNP	A	TCGA-06-0188-01A-01W-0254-08	38224856	48540562	32654648	50	2467											
RAVER1	125950	broad.mit.edu	37	chr19	10434237	10434237	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctgcccatcctggccgcaCgccagctgccggaggaaggc	14	16	0	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr19:10434237C>T	uc002moa.2	-	4	893	c.813G>A	c.(811-813)GCG>GCA	p.A271A		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	254	RRM 3.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CCTGGCCGCACGCCAGCTGCC	0.652													T	10434237	T	T	10434237	2	4	39	1	0	0	0	0	0	0	0	1	13094	523	19	1		1	RAVER1	19	10434237	Silent	SNP	C	TCGA-06-0188-01A-01W-0254-08		10434237	48694746	51	2468											
ITSN1	6453	broad.mit.edu	37	chr21	35230998	35230998	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatctgtagatttttcaAaaacccctgatggagtctga	8	9	3	3			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr21:35230998A>G	uc002yta.1	+	31	4060	c.3792A>G	c.(3790-3792)CAA>CAG	p.Q1264Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002ytb.1_Silent_p.Q1259Q|ITSN1_uc002ytj.2_Silent_p.Q1259Q|ITSN1_uc010gmm.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1264	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AGATTTTTCAAAAACCCCTGA	0.428													G	35230998	G	G	35230998	2	3	39	1	0	0	0	0	0	0	0	1	7926	11	1	4		4	ITSN1	21	35230998	Silent	SNP	A	TCGA-06-0188-01A-01W-0254-08		35230998	12898897	52	2469											
UMODL1	89766	broad.mit.edu	37	chr21	43524017	43524017	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtggtgtctgacttgtacCgaagtgggaagctgagaatg	15	6	1	2			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr21:43524017C>T	uc002zaf.1	+	9	1339	c.1339C>T	c.(1339-1341)CGA>TGA	p.R447*	UMODL1_uc002zad.1_Nonsense_Mutation_p.R375*|UMODL1_uc002zae.1_Nonsense_Mutation_p.R375*|UMODL1_uc002zag.1_Nonsense_Mutation_p.R447*|UMODL1_uc010gow.1_Nonsense_Mutation_p.R239*|UMODL1_uc002zai.1_Nonsense_Mutation_p.R98*|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Nonsense_Mutation_p.R98*|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Nonsense_Mutation_p.R192*|C21orf128_uc002zak.2_Silent_p.S72S	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	447	Extracellular (Potential).|SEA 1.		R -> Q.			cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TGACTTGTACCGAAGTGGGAA	0.562													T	43524017	T	T	43524017	4	4	39	1	0	0	0	0	0	1	0	0	16977	644	23	2	1373	2	UMODL1	21	43524017	Nonsense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08	8293019	43524017	4605878	53	2470											
KRTAP10-3	386682	broad.mit.edu	37	chr21	45978434	45978434	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggccgcctggcagcagggGctggacacacagctcactgg	15	14	1	0			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr21:45978434G>A	uc002zfj.1	-	1	210	c.165C>T	c.(163-165)AGC>AGT	p.S55S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198696	NP_941969	P60369	KR103_HUMAN	keratin associated protein 10-3	55	18 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						GGCAGCAGGGGCTGGACACAC	0.652													A	45978434	A	A	45978434	2	1	39	1	0	0	0	0	0	0	0	1	8510	1194	42	3		3	KRTAP10-3	21	45978434	Silent	SNP	G	TCGA-06-0188-01A-01W-0254-08	2454417	45978434	2151461	54	2471											
LZTR1	8216	broad.mit.edu	37	chr22	21351542	21351542	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctccaagttgcccaccctgCggtcgctgagccagcagctg	11	16	1	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chr22:21351542C>T	uc002zto.2	+	21	2531	c.2428C>T	c.(2428-2430)CGG>TGG	p.R810W	LZTR1_uc002ztn.2_Missense_Mutation_p.R769W|LZTR1_uc011ahy.1_Missense_Mutation_p.R791W|LZTR1_uc002ztp.2_3'UTR	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	810					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GCCCACCCTGCGGTCGCTGAG	0.642													T	21351542	T	T	21351542	3	4	39	1	0	0	0	0	1	0	0	0	9137	759	27	1	2510	1	LZTR1	22	21351542	Missense_Mutation	SNP	C	TCGA-06-0188-01A-01W-0254-08		21351542	29953024	55	2472											
ZNF41	7592	broad.mit.edu	37	chrX	47308259	47308259	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgggggaagactttgttgcTtttgtcacattcacgggact	12	8	2	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chrX:47308259T>C	uc004dhs.3	-	4	1103	c.1036A>G	c.(1036-1038)AGC>GGC	p.S346G	ZNF41_uc004dhu.3_Missense_Mutation_p.S338G|ZNF41_uc004dht.3_Missense_Mutation_p.S218G|ZNF41_uc004dhv.3_Missense_Mutation_p.S314G|ZNF41_uc004dhw.3_Missense_Mutation_p.S306G|ZNF41_uc004dhy.3_Missense_Mutation_p.S304G|ZNF41_uc004dhx.3_Missense_Mutation_p.S304G|ZNF41_uc011mlm.1_Missense_Mutation_p.S218G	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	346	C2H2-type 2; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				ACTTTGTTGCTTTTGTCACAT	0.418													C	47308259	C	C	47308259	3	2	39	1	0	0	0	0	1	0	0	0	17886	1609	56	4	1433	4	ZNF41	23	47308259	Missense_Mutation	SNP	T	TCGA-06-0188-01A-01W-0254-08		47308259	107962301	56	2473											
BCORL1	63035	broad.mit.edu	37	chrX	129190028	129190028	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gatcccccccaggctcctctGagactgtggagctggtgcgg	14	14	1	1			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chrX:129190028G>T	uc004evb.1	+	13	5167	c.5053G>T	c.(5053-5055)GAG>TAG	p.E1685*	BCORL1_uc004evc.1_Nonsense_Mutation_p.E521*	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1685					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						AGGCTCCTCTGAGACTGTGGA	0.627													T	129190028	T	T	129190028	4	4	39	1	0	0	0	0	0	1	0	0	1387	1291	45	5	5325	5	BCORL1	23	129190028	Nonsense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	81881769	129190028	26080532	57	2474											
PASD1	139135	broad.mit.edu	37	chrX	150770028	150770028	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tacgtcactgaataatgaatGaagatgagaggggaaaagag	13	3	1	6			TCGA-06-0188-01A-01W-0254-08	TCGA-06-0188-10B-01W-0254-08									Somatic	Phase_I	Capture				Illumina GAIIx	cc0c78e7-1d76-45e6-b043-dc209bb9a32a	bb4d23a6-f348-4f55-b06f-0c47175c8836	g.chrX:150770028G>T	uc004fev.3	+	2	335	c.3G>T	c.(1-3)ATG>ATT	p.M1I		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	1						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AATAATGAATGAAGATGAGAG	0.408													T	150770028	T	T	150770028	3	4	39	1	0	0	0	0	1	0	0	0	11471	1290	45	5	5	5	PASD1	23	150770028	Missense_Mutation	SNP	G	TCGA-06-0188-01A-01W-0254-08	21580000	150770028	4500532	58	2475											
HMCN1	83872	broad.mit.edu	37	chr1	185815175	185815175	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cagaaattggcccagtgacaAttaccacagatcccaagaaa	7	11	0	4			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr1:185815175A>T	uc001grq.1	+	2	515	c.286A>T	c.(286-288)ATT>TTT	p.I96F		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	96	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CCCAGTGACAATTACCACAGA	0.358													T	185815175	T	T	185815175	3	4	40	1	0	0	0	0	1	0	0	0	7220	101	4	5	292	5	HMCN1	1	185815175	Missense_Mutation	SNP	A	TCGA-06-0189-01A-01D-1491-08		185815175	63435446	1	2476											
UXS1	80146	broad.mit.edu	37	chr2	106761696	106761696	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggttaatcaactcgaagttcTcatgtccgatccagtgctcc	8	12	2	0			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr2:106761696T>C	uc002tdm.2	-	6	505	c.407A>G	c.(406-408)GAG>GGG	p.E136G	UXS1_uc002tdn.2_Missense_Mutation_p.E141G|UXS1_uc002tdo.2_Missense_Mutation_p.E79G|UXS1_uc010ywh.1_Intron	NM_025076	NP_079352	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	136	NAD.|Lumenal (Potential).				cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2						CTCGAAGTTCTCATGTCCGAT	0.512													C	106761696	C	C	106761696	3	2	40	1	0	0	0	0	1	0	0	0	17106	1551	54	4	895	4	UXS1	2	106761696	Missense_Mutation	SNP	T	TCGA-06-0189-01A-01D-1491-08		106761696	136437677	2	2477											
NCKAP5	344148	broad.mit.edu	37	chr2	133541813	133541813	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtggatctgatcgtaattcAaagaggggccctgagctctc	12	9	3	3			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr2:133541813A>C	uc002ttp.2	-	14	2945	c.2571T>G	c.(2569-2571)TTT>TTG	p.F857L	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	857							protein binding				0						ATCGTAATTCAAAGAGGGGCC	0.532													C	133541813	C	C	133541813	3	2	40	1	0	0	0	0	1	0	0	0	10223	127	5	5	3186	5	NCKAP5	2	133541813	Missense_Mutation	SNP	A	TCGA-06-0189-01A-01D-1491-08	26780117	133541813	109657560	3	2478											
TM4SF19	116211	broad.mit.edu	37	chr3	196051173	196051173	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtctttgaatgggtaaccatAtttccaagcttgtgtctgat	9	7	2	2			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr3:196051173A>G	uc003fwl.1	-	4	543	c.418T>C	c.(418-420)TAT>CAT	p.Y140H	TM4SF19_uc003fwj.2_RNA|uc003fwk.1_3'UTR|TM4SF19_uc010iad.1_Missense_Mutation_p.Y140H|TM4SF19_uc011btv.1_Missense_Mutation_p.Y114H	NM_138461	NP_612470	Q96DZ7	T4S19_HUMAN	transmembrane 4 L six family member 19	140	Extracellular (Potential).					integral to membrane					0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;3.94e-24)|all cancers(36;4.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.53e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		GGGTAACCATATTTCCAAGCT	0.438													G	196051173	G	G	196051173	3	3	40	1	0	0	0	0	1	0	0	0	15965	449	16	4	219	4	TM4SF19	3	196051173	Missense_Mutation	SNP	A	TCGA-06-0189-01A-01D-1491-08		196051173	1971257	4	2479											
UGT2B4	7363	broad.mit.edu	37	chr4	70359506	70359506	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttgaaaatcccagtagtttcGaataagccatatgtcagctt	7	8	1	1			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr4:70359506G>A	uc003hek.3	-	2	822	c.775C>T	c.(775-777)CGA>TGA	p.R259*	UGT2B4_uc011cap.1_Nonsense_Mutation_p.R123*|UGT2B4_uc003hel.3_Nonsense_Mutation_p.R259*	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	259					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CAGTAGTTTCGAATAAGCCAT	0.413													A	70359506	A	A	70359506	4	1	40	1	0	0	0	0	0	1	0	0	16958	1066	37	2	831	2	UGT2B4	4	70359506	Nonsense_Mutation	SNP	G	TCGA-06-0189-01A-01D-1491-08		70359506	120794770	5	2480											
STK10	6793	broad.mit.edu	37	chr5	171520876	171520876	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagactggctgggtgccagcGgggtggaaggtgactcctcg	19	9	0	2			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr5:171520876G>A	uc003mbo.1	-	9	1394	c.1094C>T	c.(1093-1095)CCG>CTG	p.P365L		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	365							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGGTGCCAGCGGGGTGGAAGG	0.587													A	171520876	A	A	171520876	3	1	40	1	0	0	0	0	1	0	0	0	15285	1116	39	2	1856	2	STK10	5	171520876	Missense_Mutation	SNP	G	TCGA-06-0189-01A-01D-1491-08		171520876	9394384	6	2481											
RUNX2	860	broad.mit.edu	37	chr6	45514682	45514682	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacctttacttacaccccGccagtcacctcaggcatgtc	6	18	2	0			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr6:45514682G>A	uc011dvx.1	+	9	1416	c.1206G>A	c.(1204-1206)CCG>CCA	p.P402P	RUNX2_uc011dvy.1_Silent_p.P380P|RUNX2_uc003oxt.2_Silent_p.P388P	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	402	Interaction with MYST3 (By similarity).|Pro/Ser/Thr-rich.|Interaction with MYST4.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						CTTACACCCCGCCAGTCACCT	0.577													A	45514682	A	A	45514682	2	1	40	1	0	0	0	0	0	0	0	1	13748	1074	38	1		1	RUNX2	6	45514682	Silent	SNP	G	TCGA-06-0189-01A-01D-1491-08		45514682	125600385	7	2482											
WBSCR27	155368	broad.mit.edu	37	chr7	73249094	73249094	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacttcctcaacctgggtcgCcttccactttcggtacaggt	8	15	1	0			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr7:73249094C>T	uc003tzj.2	-	6	757	c.717G>A	c.(715-717)AGG>AGA	p.R239R	RFC2_uc011kfa.1_Intron	NM_152559	NP_689772	Q8N6F8	WBS27_HUMAN	Williams-Beuren syndrome chromosome region 27	239										central_nervous_system(1)	1		Lung NSC(55;0.159)				ACCTGGGTCGCCTTCCACTTT	0.632													T	73249094	T	T	73249094	2	4	40	1	0	0	0	0	0	0	0	1	17263	738	26	3		3	WBSCR27	7	73249094	Silent	SNP	C	TCGA-06-0189-01A-01D-1491-08		73249094	85889569	8	2483											
CUX1	1523	broad.mit.edu	37	chr7	101847816	101847816	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagggtgttctacccgtccAgggccagcagcaagggccag	14	14	1	0			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr7:101847816A>G	uc003uyx.3	+	19	3091	c.3053A>G	c.(3052-3054)CAG>CGG	p.Q1018R	CUX1_uc003uys.3_Missense_Mutation_p.Q1029R|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	1018	CUT 2.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CTACCCGTCCAGGGCCAGCAG	0.647													G	101847816	G	G	101847816	3	3	40	1	0	0	0	0	1	0	0	0	4064	188	7	4	3194	4	CUX1	7	101847816	Missense_Mutation	SNP	A	TCGA-06-0189-01A-01D-1491-08	28598722	101847816	57290847	9	2484											
AASS	10157	broad.mit.edu	37	chr7	121756793	121756793	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgatgacgacttaacaccGtcccatacacttttctgagg	8	11	1	3			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr7:121756793G>A	uc003vka.2	-	7	884	c.788C>T	c.(787-789)ACG>ATG	p.T263M	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Missense_Mutation_p.T263M|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	263	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	ACTTAACACCGTCCCATACAC	0.353													A	121756793	A	A	121756793	3	1	40	1	0	0	0	0	1	0	0	0	24	1145	40	1	2060	1	AASS	7	121756793	Missense_Mutation	SNP	G	TCGA-06-0189-01A-01D-1491-08	19908977	121756793	37381870	10	2485											
GRM8	2918	broad.mit.edu	37	chr7	126882805	126882805	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cacggagcttgctgcagcacCtatgacgccagaaatcttgt	10	12	1	2			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr7:126882805C>G	uc003vlr.2	-	1	765	c.454G>C	c.(454-456)GGT>CGT	p.G152R	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.G152R|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	152	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GCTGCAGCACCTATGACGCCA	0.433										HNSCC(24;0.065)			G	126882805	G	G	126882805	3	3	40	1	0	0	0	0	1	0	0	0	6803	681	24	5	2362	5	GRM8	7	126882805	Missense_Mutation	SNP	C	TCGA-06-0189-01A-01D-1491-08	5126012	126882805	32255858	11	2486											
PHF20L1	51105	broad.mit.edu	37	chr8	133829196	133829196	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgagcggagaagaagatctcAgcgtttagccaccttaccca	10	11	1	4			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr8:133829196A>C	uc003ytt.2	+	11	1572	c.1247A>C	c.(1246-1248)CAG>CCG	p.Q416P	PHF20L1_uc003yts.2_Missense_Mutation_p.Q416P|PHF20L1_uc011lja.1_Missense_Mutation_p.Q390P|PHF20L1_uc003ytu.1_Intron	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	416							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			AGAAGATCTCAGCGTTTAGCC	0.453													C	133829196	C	C	133829196	3	2	40	1	0	0	0	0	1	0	0	0	11832	188	7	5	1291	5	PHF20L1	8	133829196	Missense_Mutation	SNP	A	TCGA-06-0189-01A-01D-1491-08		133829196	12534826	12	2487											
OR5D13	390142	broad.mit.edu	37	chr11	55541191	55541191	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttggttgtggaatacagaaCcatctctttctctggttgca	9	9	2	1			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr11:55541191C>A	uc010ril.1	+	1	278	c.278C>A	c.(277-279)ACC>AAC	p.T93N		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				GAATACAGAACCATCTCTTTC	0.398													A	55541191	A	A	55541191	3	1	40	1	0	0	0	0	1	0	0	0	11154	507	18	5	280	5	OR5D13	11	55541191	Missense_Mutation	SNP	C	TCGA-06-0189-01A-01D-1491-08		55541191	79465325	13	2488											
ABCC9	10060	broad.mit.edu	37	chr12	22069980	22069980	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtccaagccagactgacagTacttaaccaattttattgtt	6	9	0	2			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr12:22069980T>C	uc001rfi.1	-	4	484	c.464A>G	c.(463-465)TAC>TGC	p.Y155C	ABCC9_uc001rfh.2_Missense_Mutation_p.Y155C|ABCC9_uc001rfj.1_Missense_Mutation_p.Y155C	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	155	Extracellular (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGACTGACAGTACTTAACCAA	0.388													C	22069980	C	C	22069980	3	2	40	1	0	0	0	0	1	0	0	0	59	1638	57	4	4467	4	ABCC9	12	22069980	Missense_Mutation	SNP	T	TCGA-06-0189-01A-01D-1491-08		22069980	111781915	14	2489											
PKP2	5318	broad.mit.edu	37	chr12	33030958	33030958	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgatgccaggaggacctggAagccctgttctgagtgacgg	15	10	1	3			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr12:33030958A>C	uc001rlj.3	-	3	971	c.856T>G	c.(856-858)TCC>GCC	p.S286A	PKP2_uc001rlk.3_Missense_Mutation_p.S286A|PKP2_uc010skj.1_Missense_Mutation_p.S286A	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	286					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GAGGACCTGGAAGCCCTGTTC	0.652													C	33030958	C	C	33030958	3	2	40	1	0	0	0	0	1	0	0	0	11985	246	9	5	1837	5	PKP2	12	33030958	Missense_Mutation	SNP	A	TCGA-06-0189-01A-01D-1491-08	10960978	33030958	100820937	15	2490											
MFSD5	84975	broad.mit.edu	37	chr12	53647741	53647741	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgatccctgagacagagcaGgctggtgtactcaactggtt	13	9	1	3			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr12:53647741G>A	uc001sci.1	+	2	1313	c.1122G>A	c.(1120-1122)CAG>CAA	p.Q374Q	MFSD5_uc001sch.1_Silent_p.Q481Q	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	374					transport	integral to membrane				skin(2)|ovary(1)	3						AGACAGAGCAGGCTGGTGTAC	0.502													A	53647741	A	A	53647741	2	1	40	1	0	0	0	0	0	0	0	1	9534	991	35	3		3	MFSD5	12	53647741	Silent	SNP	G	TCGA-06-0189-01A-01D-1491-08	20616783	53647741	80204154	16	2491											
GLT1D1	144423	broad.mit.edu	37	chr12	129360490	129360490	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggctgcagggcacgtgtgcGttttgaaggatgcctttgac	15	8	0	2	rs146263464	byFrequency	TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr12:129360490G>A	uc010tbh.1	+	2	76	c.67G>A	c.(67-69)GTT>ATT	p.V23I	GLT1D1_uc001uhx.1_Missense_Mutation_p.V34I|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	34					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		GCACGTGTGCGTTTTGAAGGA	0.473													A	129360490	A	A	129360490	3	1	40	1	0	0	0	0	1	0	0	0	6465	1145	40	1	106	1	GLT1D1	12	129360490	Missense_Mutation	SNP	G	TCGA-06-0189-01A-01D-1491-08	75712749	129360490	4491405	17	2492											
C14orf115	55237	broad.mit.edu	37	chr14	74824348	74824348	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctactctcacctctgtgagCgctacagcgtcaccaaaagc	8	15	3	1			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr14:74824348C>T	uc001xpw.3	+	2	1053	c.862C>T	c.(862-864)CGC>TGC	p.R288C		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	288					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		CCTCTGTGAGCGCTACAGCGT	0.647													T	74824348	T	T	74824348	3	4	40	1	0	0	0	0	1	0	0	0	1740	768	27	1	864	1	C14orf115	14	74824348	Missense_Mutation	SNP	C	TCGA-06-0189-01A-01D-1491-08		74824348	32525192	18	2493											
PLA2G4E	123745	broad.mit.edu	37	chr15	42298316	42298316	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagacactcaactctagcaCgttctaggggagaaggaagg	12	9	3	2			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr15:42298316C>T	uc001zow.1	-	3	310	c.310G>A	c.(310-312)GTG>ATG	p.V104M		NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	115	C2.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		AACTCTAGCACGTTCTAGGGG	0.507													T	42298316	T	T	42298316	3	4	40	1	0	0	0	0	1	0	0	0	12005	536	19	1	2277	1	PLA2G4E	15	42298316	Missense_Mutation	SNP	C	TCGA-06-0189-01A-01D-1491-08		42298316	60233076	19	2494											
DET1	55070	broad.mit.edu	37	chr15	89070986	89070986	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacagcaatcacctctgtcGtcaccatattgtacaccaca	4	15	3	0			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr15:89070986G>A	uc002bmr.2	-	3	1267	c.1115C>T	c.(1114-1116)ACG>ATG	p.T372M	DET1_uc002bmp.3_RNA|DET1_uc010bnk.2_Intron|DET1_uc002bmq.2_Missense_Mutation_p.T383M	NM_001144074	NP_001137546	Q7L5Y6	DET1_HUMAN	de-etiolated 1 isoform 2	372						nucleus				lung(1)|pancreas(1)	2	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			CACCTCTGTCGTCACCATATT	0.433													A	89070986	A	A	89070986	3	1	40	1	0	0	0	0	1	0	0	0	4450	1145	40	1	549	1	DET1	15	89070986	Missense_Mutation	SNP	G	TCGA-06-0189-01A-01D-1491-08	46772670	89070986	13460406	20	2495											
CACNA1H	8912	broad.mit.edu	37	chr16	1257299	1257299	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacccaggaggactggaacGtggtcctgtacaacggcatg	14	10	0	1			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr16:1257299G>A	uc002cks.2	+	14	3180	c.2932G>A	c.(2932-2934)GTG>ATG	p.V978M	CACNA1H_uc002ckt.2_Missense_Mutation_p.V978M|CACNA1H_uc002cku.2_5'Flank|CACNA1H_uc010brj.2_5'Flank|CACNA1H_uc002ckv.2_5'Flank	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	978	II.|Extracellular (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGACTGGAACGTGGTCCTGTA	0.632													A	1257299	A	A	1257299	3	1	40	1	0	0	0	0	1	0	0	0	2545	1145	40	1	2982	1	CACNA1H	16	1257299	Missense_Mutation	SNP	G	TCGA-06-0189-01A-01D-1491-08		1257299	89097454	21	2496											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	13	14	3	0	rs28934578		TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578406	T	T	7578406	3	4	40	1	0	0	0	0	1	0	0	0	16378	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-06-0189-01A-01D-1491-08		7578406	73616804	22	2497											
ATP6V0A1	535	broad.mit.edu	37	chr17	40646356	40646356	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttggtttcttcatagctccGtatactattatcacgttccc	5	11	3	0	rs142629560		TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr17:40646356G>A	uc002hzr.2	+	12	1346	c.1179G>A	c.(1177-1179)CCG>CCA	p.P393P	ATP6V0A1_uc002hzq.2_Silent_p.P393P|ATP6V0A1_uc002hzs.2_Silent_p.P400P|ATP6V0A1_uc010wgj.1_Silent_p.P350P|ATP6V0A1_uc010wgk.1_Silent_p.P350P|ATP6V0A1_uc010cyg.2_Silent_p.P39P|ATP6V0A1_uc010wgl.1_Silent_p.P252P	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	393	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		TCATAGCTCCGTATACTATTA	0.368													A	40646356	A	A	40646356	2	1	40	1	0	0	0	0	0	0	0	1	1168	1132	40	1		1	ATP6V0A1	17	40646356	Silent	SNP	G	TCGA-06-0189-01A-01D-1491-08	33067950	40646356	40548854	23	2498											
SFRS2	6427	broad.mit.edu	37	chr17	74732284	74732284	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ctcttcaggagacttgggggGactcttcgatcgcgacctgg	14	11	3	1			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr17:74732284G>T	uc002jsv.2	-	2	795	c.625C>A	c.(625-627)CCC>ACC	p.P209T	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Missense_Mutation_p.P209T|SFRS2_uc010wtg.1_Missense_Mutation_p.P197T|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	209	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						GACTTGGGGGGACTCTTCGAT	0.537													T	74732284	T	T	74732284	3	4	40	1	0	0	0	0	1	0	0	0	14175	1174	41	5	44	5	SFRS2	17	74732284	Missense_Mutation	SNP	G	TCGA-06-0189-01A-01D-1491-08	34085928	74732284	6462926	24	2499											
STXBP2	6813	broad.mit.edu	37	chr19	7711219	7711219	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gctggaccccggtcatcaagGatgtaatggaggtactgggt	15	8	2	0			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr19:7711219G>C	uc002mha.3	+	16	1486	c.1441G>C	c.(1441-1443)GAT>CAT	p.D481H	STXBP2_uc002mhb.3_Missense_Mutation_p.D478H|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Missense_Mutation_p.D492H|STXBP2_uc010dvk.2_Missense_Mutation_p.D449H|STXBP2_uc002mhc.3_Intron|STXBP2_uc002mhe.1_Missense_Mutation_p.D109H	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	481					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						GGTCATCAAGGATGTAATGGA	0.677													C	7711219	C	C	7711219	3	2	40	1	0	0	0	0	1	0	0	0	15352	1174	41	5	1503	5	STXBP2	19	7711219	Missense_Mutation	SNP	G	TCGA-06-0189-01A-01D-1491-08		7711219	51417764	25	2500											
MUC16	94025	broad.mit.edu	37	chr19	9045842	9045842	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tcctggaaaattctgggggtCcaactgaagttacagatggt	12	7	1	2			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr19:9045842C>G	uc002mkp.2	-	5	35993	c.35789G>C	c.(35788-35790)GGA>GCA	p.G11930A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11932	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCTGGGGGTCCAACTGAAGT	0.493													G	9045842	G	G	9045842	3	3	40	1	0	0	0	0	1	0	0	0	9973	855	30	5	8054	5	MUC16	19	9045842	Missense_Mutation	SNP	C	TCGA-06-0189-01A-01D-1491-08	1334623	9045842	50083141	26	2501											
CST9	128822	broad.mit.edu	37	chr20	23586397	23586397	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actattttattattaccaccCatttcctcttcagaacacca	1	13	2	1			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr20:23586397C>T	uc002wtl.2	-	1	214	c.105G>A	c.(103-105)ATG>ATA	p.M35I		NM_001008693	NP_001008693	Q5W186	CST9_HUMAN	cystatin 9 precursor	35						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Colorectal(13;0.0993)					TATTACCACCCATTTCCTCTT	0.517													T	23586397	T	T	23586397	3	4	40	1	0	0	0	0	1	0	0	0	3979	594	21	3	382	3	CST9	20	23586397	Missense_Mutation	SNP	C	TCGA-06-0189-01A-01D-1491-08		23586397	39439123	27	2502											
NPBWR2	2832	broad.mit.edu	37	chr20	62738130	62738130	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgttggcacccatcgtggGgagggagaaggagcccctgc	17	11	0	1			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chr20:62738130G>A	uc011abt.1	-	1	55	c.55C>T	c.(55-57)CCC>TCC	p.P19S		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	19	Extracellular (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					CCCATCGTGGGGAGGGAGAAG	0.637													A	62738130	A	A	62738130	3	1	40	1	0	0	0	0	1	0	0	0	10569	1232	43	3	949	3	NPBWR2	20	62738130	Missense_Mutation	SNP	G	TCGA-06-0189-01A-01D-1491-08	39151733	62738130	287390	28	2503											
CXorf23	256643	broad.mit.edu	37	chrX	19968977	19968977	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcatttggatctattatttTgatcagagtctgaggaattt	9	4	4	3			TCGA-06-0189-01A-01D-1491-08	TCGA-06-0189-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	25c64c53-746c-4e92-976a-8bd947fb9c7f	3782bae7-658a-4167-9d2b-8e8cdcffc69f	g.chrX:19968977T>G	uc004czp.2	-	7	1639	c.1639A>C	c.(1639-1641)AAA>CAA	p.K547Q	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Missense_Mutation_p.K112Q|CXorf23_uc004czo.2_Missense_Mutation_p.K497Q	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	547						mitochondrion				lung(1)|skin(1)	2						TCTATTATTTTGATCAGAGTC	0.363													G	19968977	G	G	19968977	3	3	40	1	0	0	0	0	1	0	0	0	4103	1821	63	5	429	5	CXorf23	23	19968977	Missense_Mutation	SNP	T	TCGA-06-0189-01A-01D-1491-08		19968977	135301583	29	2504											
MECR	51102	broad.mit.edu	37	chr1	29557372	29557372	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgggagcagcccccgccacTgccgggcgggggttcgcacc	16	17	0	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr1:29557372T>G	uc001brq.1	-	1	83	c.47A>C	c.(46-48)CAG>CCG	p.Q16P	MECR_uc001brp.1_5'UTR|MECR_uc001brr.1_5'UTR|MECR_uc001brs.1_RNA|MECR_uc001brt.1_5'UTR|MECR_uc010ofz.1_Missense_Mutation_p.Q16P	NM_016011	NP_057095	Q9BV79	MECR_HUMAN	trans-2-enoyl-CoA reductase, mitochondrial	16					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			ovary(1)	1		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		CCCCCGCCACTGCCGGGCGGG	0.692													G	29557372	G	G	29557372	3	3	41	1	0	0	0	0	1	0	0	0	9424	1580	55	5	1114	5	MECR	1	29557372	Missense_Mutation	SNP	T	TCGA-06-0192-01B-01W-0348-08		29557372	219693249	1	2505											
FOXJ3	22887	broad.mit.edu	37	chr1	42657151	42657151	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggggaacgctgcggatgctGcggtaaaccatgcggtcgat	16	9	0	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr1:42657151G>A	uc001che.2	-	11	1486	c.1174C>T	c.(1174-1176)CAG>TAG	p.Q392*	FOXJ3_uc001chf.2_Nonsense_Mutation_p.Q392*|FOXJ3_uc001chg.2_Nonsense_Mutation_p.Q392*|FOXJ3_uc001chh.1_Nonsense_Mutation_p.Q358*	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	392					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TGCGGATGCTGCGGTAAACCA	0.592													A	42657151	A	A	42657151	4	1	41	1	0	0	0	0	0	1	0	0	6013	1328	46	3	714	3	FOXJ3	1	42657151	Nonsense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	13099779	42657151	206593470	2	2506											
ELTD1	64123	broad.mit.edu	37	chr1	79403509	79403509	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tacctatatccgttgaatttGtatcaaactctgtggtcttt	6	8	3	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr1:79403509G>T	uc001diq.3	-	6	899	c.743C>A	c.(742-744)ACA>AAA	p.T248K		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	248	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CGTTGAATTTGTATCAAACTC	0.378													T	79403509	T	T	79403509	3	4	41	1	0	0	0	0	1	0	0	0	5084	1377	48	5	1369	5	ELTD1	1	79403509	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	36746358	79403509	169847112	3	2507											
LCE1F	353137	broad.mit.edu	37	chr1	152749095	152749095	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgagccaccacagacggcGtaggtcccaccgccacagac	10	18	0	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr1:152749095G>A	uc010pdv.1	+	1	248	c.248G>A	c.(247-249)CGT>CAT	p.R83H		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	83	Poly-Arg.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACAGACGGCGTAGGTCCCAC	0.706													A	152749095	A	A	152749095	3	1	41	1	0	0	0	0	1	0	0	0	8664	1145	40	1	250	1	LCE1F	1	152749095	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	73345586	152749095	96501526	4	2508											
TOMM40L	84134	broad.mit.edu	37	chr1	161198259	161198259	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaatgtgggatcaggcgggGcccatgcaagttactaccac	13	10	1	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr1:161198259G>A	uc001fzd.2	+	8	878	c.649G>A	c.(649-651)GCC>ACC	p.A217T	TOMM40L_uc010pkl.1_Missense_Mutation_p.A183T|TOMM40L_uc009wue.2_Missense_Mutation_p.A99T|TOMM40L_uc009wuf.1_RNA|TOMM40L_uc001fze.2_Missense_Mutation_p.A217T	NM_032174	NP_115550	Q969M1	TM40L_HUMAN	translocase of outer mitochondrial membrane 40	217					protein transport	mitochondrial outer membrane|pore complex	porin activity|voltage-gated anion channel activity			large_intestine(1)	1	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			ATCAGGCGGGGCCCATGCAAG	0.488													A	161198259	A	A	161198259	3	1	41	1	0	0	0	0	1	0	0	0	16356	1203	42	3	675	3	TOMM40L	1	161198259	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	8449164	161198259	88052362	5	2509											
FMOD	2331	broad.mit.edu	37	chr1	203316988	203316988	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcactggtgatctggttgccGtggagagcaatccagagcag	14	9	2	3	rs141206727		TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr1:203316988G>A	uc001gzr.2	-	2	547	c.411C>T	c.(409-411)CAC>CAT	p.H137H	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	137	LRR 2.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			TCTGGTTGCCGTGGAGAGCAA	0.557													A	203316988	A	A	203316988	2	1	41	1	0	0	0	0	0	0	0	1	5959	1136	40	1		1	FMOD	1	203316988	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	42118729	203316988	45933633	6	2510											
C1orf107	27042	broad.mit.edu	37	chr1	210008454	210008454	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catgtgaacaaagaactgaaAgaaaaagcaattcaggctgt	9	6	1	4			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr1:210008454A>G	uc001hhr.1	+	5	673	c.597A>G	c.(595-597)AAA>AAG	p.K199K	C1orf107_uc009xcu.1_5'UTR	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	199					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		AAGAACTGAAAGAAAAAGCAA	0.403													G	210008454	G	G	210008454	2	3	41	1	0	0	0	0	0	0	0	1	1981	69	3	4		4	C1orf107	1	210008454	Silent	SNP	A	TCGA-06-0192-01B-01W-0348-08	6691466	210008454	39242167	7	2511											
CHRM3	1131	broad.mit.edu	37	chr1	240071276	240071276	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccatcacgaggccgctcacGtaccgagccaaacgaacaac	8	16	2	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr1:240071276G>A	uc001hyp.2	+	5	1304	c.525G>A	c.(523-525)ACG>ACA	p.T175T		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	175	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GGCCGCTCACGTACCGAGCCA	0.507													A	240071276	A	A	240071276	2	1	41	1	0	0	0	0	0	0	0	1	3378	1132	40	1		1	CHRM3	1	240071276	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	30062822	240071276	9179345	8	2512											
OR2T3	343173	broad.mit.edu	37	chr1	248637245	248637245	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctcctgctctgacgtctcCctctataagacgctcatgta	6	15	5	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr1:248637245C>T	uc001iel.1	+	1	594	c.594C>T	c.(592-594)TCC>TCT	p.S198S		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	198	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGACGTCTCCCTCTATAAGA	0.522													T	248637245	T	T	248637245	2	4	41	1	0	0	0	0	0	0	0	1	11023	610	22	3		3	OR2T3	1	248637245	Silent	SNP	C	TCGA-06-0192-01B-01W-0348-08	8565969	248637245	613376	9	2513											
HPCAL1	3241	broad.mit.edu	37	chr2	10560060	10560060	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaacttcttcccctacggCgacgcttccaagttcgccga	8	17	1	0	rs142524922		TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr2:10560060C>T	uc002raj.2	+	3	551	c.177C>T	c.(175-177)GGC>GGT	p.G59G	HPCAL1_uc002rak.2_Silent_p.G59G|HPCAL1_uc002ral.2_Silent_p.G59G|HPCAL1_uc010exe.2_RNA|HPCAL1_uc010exf.2_Silent_p.G59G	NM_002149	NP_002140	P37235	HPCL1_HUMAN	hippocalcin-like 1	59							calcium ion binding			pancreas(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		TCCCCTACGGCGACGCTTCCA	0.602													T	10560060	T	T	10560060	2	4	41	1	0	0	0	0	0	0	0	1	7330	755	27	1		1	HPCAL1	2	10560060	Silent	SNP	C	TCGA-06-0192-01B-01W-0348-08		10560060	232639313	10	2514											
IWS1	55677	broad.mit.edu	37	chr2	128262546	128262547	+	Frame_Shift_Ins	INS	-	G	G													cagtttctgagtcactggcaINSggccccttctgaggcccctc							TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr2:128262546_128262547insG	uc002ton.2	-	3	1235_1236	c.932_933insC	c.(931-933)CCTfs	p.P311fs	IWS1_uc010yzl.1_RNA|uc002too.1_5'Flank|IWS1_uc010fma.2_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	311	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		AGTCACTGGCAGGCCCCTTCTG	0.54													G	128262547	G	G	128262546	7	5	41	1	0	1	1	0	0	0	0	0	7931	175	7	0	1574	0	IWS1	2	128262546	Frame_Shift_Ins	INS	-	TCGA-06-0192-01B-01W-0348-08	117702486	128262546	114936827	11	2515											
FAM123C	205147	broad.mit.edu	37	chr2	131521170	131521170	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgccatcaccatgggcatcGtcagctggctgcgccgaggc	13	15	2	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr2:131521170G>A	uc002trw.2	+	2	1715	c.1525G>A	c.(1525-1527)GTC>ATC	p.V509I	FAM123C_uc010fmv.2_Missense_Mutation_p.V509I|FAM123C_uc010fms.1_Missense_Mutation_p.V509I|FAM123C_uc010fmt.1_Missense_Mutation_p.V509I|FAM123C_uc010fmu.1_Missense_Mutation_p.V509I	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	509										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CATGGGCATCGTCAGCTGGCT	0.677													A	131521170	A	A	131521170	3	1	41	1	0	0	0	0	1	0	0	0	5424	1145	40	1	1527	1	FAM123C	2	131521170	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	3258624	131521170	111678203	12	2516											
HECW2	57520	broad.mit.edu	37	chr2	197183877	197183877	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcggaagtccctgtgtctgcGccacttgtgggctgatctac	12	12	2	1	rs111271189	byFrequency	TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr2:197183877G>A	uc002utm.1	-	9	1920	c.1737C>T	c.(1735-1737)GGC>GGT	p.G579G	HECW2_uc002utl.1_Silent_p.G223G	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	579					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CTGTGTCTGCGCCACTTGTGG	0.607													A	197183877	A	A	197183877	2	1	41	1	0	0	0	0	0	0	0	1	7043	1074	38	1		1	HECW2	2	197183877	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	65662707	197183877	46015496	13	2517											
ALS2CR12	130540	broad.mit.edu	37	chr2	202154207	202154207	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaatgttctcttccgtcaggAtctgtatggtgtgcttatac	10	8	3	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr2:202154207A>C	uc010ftg.2	-	14	1628	c.1184T>G	c.(1183-1185)ATC>AGC	p.I395S	ALS2CR12_uc002uya.3_Missense_Mutation_p.I372S|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	395	Potential.				regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TTCCGTCAGGATCTGTATGGT	0.413													C	202154207	C	C	202154207	3	2	41	1	0	0	0	0	1	0	0	0	553	333	12	5	161	5	ALS2CR12	2	202154207	Missense_Mutation	SNP	A	TCGA-06-0192-01B-01W-0348-08	4970330	202154207	41045166	14	2518											
TRPM8	79054	broad.mit.edu	37	chr2	234869620	234869620	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tcctataatgatgccctcctCacgtttgtctggaaactggt	8	11	2	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr2:234869620C>A	uc002vvh.2	+	12	1603	c.1563C>A	c.(1561-1563)CTC>CTA	p.L521L	TRPM8_uc010fyj.2_Silent_p.L209L	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	521	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	ATGCCCTCCTCACGTTTGTCT	0.507													A	234869620	A	A	234869620	2	1	41	1	0	0	0	0	0	0	0	1	16589	813	29	5		5	TRPM8	2	234869620	Silent	SNP	C	TCGA-06-0192-01B-01W-0348-08	32715413	234869620	8329753	15	2519											
GOLGA4	2803	broad.mit.edu	37	chr3	37369037	37369037	+	Nonsense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atatgaaaaattacaggcttTacaacagatggatggaagaa	9	4	0	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr3:37369037T>G	uc003cgv.2	+	14	5964	c.5660T>G	c.(5659-5661)TTA>TGA	p.L1887*	GOLGA4_uc010hgr.1_Nonsense_Mutation_p.L1448*|GOLGA4_uc003cgw.2_Nonsense_Mutation_p.L1909*|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Nonsense_Mutation_p.L1768*	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1887	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TTACAGGCTTTACAACAGATG	0.353													G	37369037	G	G	37369037	4	3	41	1	0	0	0	0	0	1	0	0	6555	1764	61	5	5784	5	GOLGA4	3	37369037	Nonsense_Mutation	SNP	T	TCGA-06-0192-01B-01W-0348-08		37369037	160653393	16	2520											
ATP13A4	84239	broad.mit.edu	37	chr3	193160209	193160209	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ccatacataatgtgtttcttCtcttctactaacgtccaaga	4	11	3	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr3:193160209C>T	uc003ftd.2	-	19	2397	c.2289G>A	c.(2287-2289)GAG>GAA	p.E763E	ATP13A4_uc003fte.1_Silent_p.E763E|ATP13A4_uc011bsr.1_Silent_p.E234E|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	763	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TGTGTTTCTTCTCTTCTACTA	0.433													T	193160209	T	T	193160209	2	4	41	1	0	0	0	0	0	0	0	1	1126	912	32	3		3	ATP13A4	3	193160209	Silent	SNP	C	TCGA-06-0192-01B-01W-0348-08	155791172	193160209	4862221	17	2521											
TMEM174	134288	broad.mit.edu	37	chr5	72469988	72469988	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaaatatactctctccctcGctagaggctattctgatata	6	10	2	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr5:72469988G>A	uc010izc.2	+	2	776	c.728G>A	c.(727-729)CGC>CAC	p.R243H		NM_153217	NP_694949	Q8WUU8	TM174_HUMAN	transmembrane protein 174	243						integral to membrane				ovary(1)	1		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		TCTCTCCCTCGCTAGAGGCTA	0.478													A	72469988	A	A	72469988	3	1	41	1	0	0	0	0	1	0	0	0	16087	1087	38	1	734	1	TMEM174	5	72469988	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08		72469988	108445272	18	2522											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768990	140768990	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcggagagcggggtggtgttCgcgcagcgcgccttcgacca	18	12	0	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr5:140768990C>T	uc003lkc.1	+	1	1539	c.1539C>T	c.(1537-1539)TTC>TTT	p.F513F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.F513F	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	513	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGTGTTCGCGCAGCGCG	0.667													T	140768990	T	T	140768990	2	4	41	1	0	0	0	0	0	0	0	1	11565	883	31	2		2	PCDHGB4	5	140768990	Silent	SNP	C	TCGA-06-0192-01B-01W-0348-08	68299002	140768990	40146270	19	2523											
WWC1	23286	broad.mit.edu	37	chr5	167868746	167868746	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggagaggtcgactcgctgGtacaaccttctcagctacaa	12	11	1	1	rs148699341		TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr5:167868746G>A	uc003lzu.2	+	16	2433	c.2340G>A	c.(2338-2340)TGG>TGA	p.W780*	WWC1_uc003lzv.2_Nonsense_Mutation_p.W780*|WWC1_uc011den.1_Nonsense_Mutation_p.W780*|WWC1_uc003lzw.2_Nonsense_Mutation_p.W579*|WWC1_uc010jjf.1_Nonsense_Mutation_p.W47*	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	780	C2.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CGACTCGCTGGTACAACCTTC	0.602													A	167868746	A	A	167868746	4	1	41	1	0	0	0	0	0	1	0	0	17408	1270	44	3	2402	3	WWC1	5	167868746	Nonsense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	27099756	167868746	13046514	20	2524											
OR2B2	81697	broad.mit.edu	37	chr6	27879956	27879956	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgaaatccacatgtgacaCaagaattattgtcagattgc	7	7	1	4			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr6:27879956C>T	uc011dkw.1	-	1	142	c.142G>A	c.(142-144)GTG>ATG	p.V48M		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	48	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACATGTGACACAAGAATTATT	0.388													T	27879956	T	T	27879956	3	4	41	1	0	0	0	0	1	0	0	0	10989	478	17	3	935	3	OR2B2	6	27879956	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08		27879956	143235111	21	2525											
MAS1L	116511	broad.mit.edu	37	chr6	29455605	29455605	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tggagacaaaggctacatgaGagagatatctgtgactcagc	12	7	2	4			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr6:29455605G>C	uc011dlq.1	-	1	75	c.75C>G	c.(73-75)CTC>CTG	p.L25L		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	25	Extracellular (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						GGCTACATGAGAGAGATATCT	0.522													C	29455605	C	C	29455605	2	2	41	1	0	0	0	0	0	0	0	1	9321	929	33	5		5	MAS1L	6	29455605	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	1575649	29455605	141659462	22	2526											
HLA-F	3134	broad.mit.edu	37	chr6	29691648	29691648	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtacgccaaggccaacgcacAgactgaccgagtggccctga	12	14	0	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr6:29691648A>G	uc010jrl.2	+	2	402	c.278A>G	c.(277-279)CAG>CGG	p.Q93R	HLA-F_uc003nnm.3_Missense_Mutation_p.Q93R|HLA-F_uc003nno.3_Missense_Mutation_p.Q93R|HLA-F_uc011dlx.1_Missense_Mutation_p.Q93R|HLA-F_uc011dly.1_RNA	NM_018950	NP_061823	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	93	Alpha-1.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						GCCAACGCACAGACTGACCGA	0.682													G	29691648	G	G	29691648	3	3	41	1	0	0	0	0	1	0	0	0	7211	188	7	4	284	4	HLA-F	6	29691648	Missense_Mutation	SNP	A	TCGA-06-0192-01B-01W-0348-08	236043	29691648	141423419	23	2527											
AGPAT1	10554	broad.mit.edu	37	chr6	32139093	32139093	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcatgttctcgacgttgcGtcctcgcacggcacacacag	9	15	2	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr6:32139093G>A	uc003oae.2	-	2	499	c.181C>T	c.(181-183)CGC>TGC	p.R61C	PPT2_uc003nzy.1_RNA|AGPAT1_uc011dpj.1_RNA|AGPAT1_uc011dpk.1_Missense_Mutation_p.T54M|AGPAT1_uc003oaf.2_Missense_Mutation_p.R61C|AGPAT1_uc003oag.2_Missense_Mutation_p.T54M|AGPAT1_uc003oah.2_Missense_Mutation_p.R61C|AGPAT1_uc003oai.1_Missense_Mutation_p.R61C|AGPAT1_uc011dpl.1_Translation_Start_Site	NM_006411	NP_006402	Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	61					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)	1						TCGACGTTGCGTCCTCGCACG	0.567													A	32139093	A	A	32139093	3	1	41	1	0	0	0	0	1	0	0	0	386	1145	40	1	694	1	AGPAT1	6	32139093	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	2447445	32139093	138975974	24	2528											
MAPK13	5603	broad.mit.edu	37	chr6	36099124	36099124	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctttcagtccgagatcttcGccaagcgcgcctaccgggag	11	15	2	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr6:36099124G>A	uc003ols.2	+	2	294	c.196G>A	c.(196-198)GCC>ACC	p.A66T	MAPK13_uc003olt.2_RNA	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	66	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						CGAGATCTTCGCCAAGCGCGC	0.662													A	36099124	A	A	36099124	3	1	41	1	0	0	0	0	1	0	0	0	9275	1087	38	1	202	1	MAPK13	6	36099124	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	3960031	36099124	135015943	25	2529											
TDRD6	221400	broad.mit.edu	37	chr6	46659003	46659003	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgccttgccaagtatactgaTggaaactggtataggggcat	12	7	0	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr6:46659003T>A	uc003oyj.2	+	1	3138	c.3138T>A	c.(3136-3138)GAT>GAA	p.D1046E	TDRD6_uc010jze.2_Missense_Mutation_p.D1040E	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1046	Tudor 5.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AGTATACTGATGGAAACTGGT	0.358													A	46659003	A	A	46659003	3	1	41	1	0	0	0	0	1	0	0	0	15731	1461	51	5	3140	5	TDRD6	6	46659003	Missense_Mutation	SNP	T	TCGA-06-0192-01B-01W-0348-08	10559879	46659003	124456064	26	2530											
TAAR1	134864	broad.mit.edu	37	chr6	132966960	132966960	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acagtggccatggaatgaatGagccaatttgttggggtatg	14	5	0	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr6:132966960G>C	uc003qdm.1	-	1	183	c.183C>G	c.(181-183)CTC>CTG	p.L61L		NM_138327	NP_612200	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	61	Helical; Name=2; (Potential).					plasma membrane					0	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	TGGAATGAATGAGCCAATTTG	0.423													C	132966960	C	C	132966960	2	2	41	1	0	0	0	0	0	0	0	1	15486	1277	45	5		5	TAAR1	6	132966960	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	86307957	132966960	38148107	27	2531											
GRM1	2911	broad.mit.edu	37	chr6	146350618	146350618	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcgggaccagcgtgggaaCgcggctggcaggctgtggac	19	11	0	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr6:146350618C>T	uc010khw.1	+	2	435	c.-35C>T	c.(-37--33)AACGC>AATGC		GRM1_uc010khu.1_Translation_Start_Site|GRM1_uc010khv.1_Translation_Start_Site|GRM1_uc003qll.2_Translation_Start_Site|GRM1_uc011edz.1_Translation_Start_Site|GRM1_uc011eea.1_Translation_Start_Site	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha						synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AGCGTGGGAACGCGGCTGGCA	0.647													T	146350618	T	T	146350618	1	4	41	1	0	0	0	0	0	0	0	0	6796	551	19	1		1	GRM1	6	146350618	Translation_Start_Site	SNP	C	TCGA-06-0192-01B-01W-0348-08	13383658	146350618	24764449	28	2532											
SNX9	51429	broad.mit.edu	37	chr6	158331016	158331016	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tctcctggttaagtttgggtCagccattccaatcccttctc	7	13	3	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr6:158331016C>T	uc003qqv.1	+	9	1081	c.908C>T	c.(907-909)TCA>TTA	p.S303L		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	303	PX.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		AAGTTTGGGTCAGCCATTCCA	0.408													T	158331016	T	T	158331016	3	4	41	1	0	0	0	0	1	0	0	0	14909	838	29	3	942	3	SNX9	6	158331016	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08	11980398	158331016	12784051	29	2533											
GPR141	353345	broad.mit.edu	37	chr7	37780793	37780793	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcaaggttgcattttataaCgaaatcttcttgagtgtaac	8	6	2	1	rs146749644	byFrequency	TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr7:37780793C>T	uc003tfm.1	+	1	798	c.798C>T	c.(796-798)AAC>AAT	p.N266N	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	266	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						CATTTTATAACGAAATCTTCT	0.383													T	37780793	T	T	37780793	2	4	41	1	0	0	0	0	0	0	0	1	6649	535	19	1		1	GPR141	7	37780793	Silent	SNP	C	TCGA-06-0192-01B-01W-0348-08		37780793	121357870	30	2534											
ABCB1	5243	broad.mit.edu	37	chr7	87190658	87190658	+	Frame_Shift_Del	DEL	C	-	-													ctcttcagctactgctccagCttttgcatacgctaagagtt							TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr7:87190658delC	uc003uiz.1	-	9	1166	c.748delG	c.(748-750)GCTfs	p.A250fs	ABCB1_uc011khc.1_Frame_Shift_Del_p.A186fs	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	250	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity	p.A250T(1)		ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ACTGCTCCAGCTTTTGCATAC	0.318													-	87190658	-	-	87190658	7	5	41	1	0	1	0	1	0	0	0	0	40	797	28	0	3178	0	ABCB1	7	87190658	Frame_Shift_Del	DEL	C	TCGA-06-0192-01B-01W-0348-08	49409865	87190658	71948005	31	2535											
HIPK2	28996	broad.mit.edu	37	chr7	139316027	139316027	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgtgtttgtgaaatataccGaatctgcaagaaaagataag	9	5	1	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr7:139316027G>A	uc003vvf.3	-	4	1405	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	HIPK2_uc003vvd.3_Missense_Mutation_p.R411W	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	411	Protein kinase.|Interaction with DAXX.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					GAAATATACCGAATCTGCAAG	0.408													A	139316027	A	A	139316027	3	1	41	1	0	0	0	0	1	0	0	0	7117	1057	37	2	2413	2	HIPK2	7	139316027	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	52125369	139316027	19822636	32	2536											
KEL	3792	broad.mit.edu	37	chr7	142658446	142658446	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggtctgggatcttgcttaCgagggccacagttctggaag	16	8	3	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr7:142658446C>T	uc003wcb.2	-	3	433	c.223_splice	c.e3+1	p.R75_splice		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase						proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					ATCTTGCTTACGAGGGCCACA	0.602													T	142658446	T	T	142658446	5	4	41	1	0	0	0	0	0	0	1	0	8142	550	19	1	2042	1	KEL	7	142658446	Splice_Site	SNP	C	TCGA-06-0192-01B-01W-0348-08	3342419	142658446	16480217	33	2537											
PCM1	5108	broad.mit.edu	37	chr8	17872225	17872226	+	Frame_Shift_Ins	INS	-	A	A													cagcctaaccctttgccgttINSacgtttacctgaaatggaac							TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr8:17872225_17872226insA	uc003wyi.3	+	36	6139_6140	c.5717_5718insA	c.(5716-5718)TTAfs	p.L1906fs	PCM1_uc011kyh.1_Frame_Shift_Ins_p.L1898fs|PCM1_uc003wyj.3_Intron|PCM1_uc011kyi.1_Frame_Shift_Ins_p.L705fs|PCM1_uc011kyj.1_Frame_Shift_Ins_p.L662fs|PCM1_uc003wyk.3_Frame_Shift_Ins_p.L588fs|PCM1_uc011kyk.1_Frame_Shift_Ins_p.L522fs	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	1906					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		CCTTTGCCGTTACGTTTACCTG	0.436			T	RET|JAK2	papillary thyroid|CML|MPD								A	17872226	A	A	17872225	7	5	41	1	0	1	1	0	0	0	0	0	11584	1764	61	0	5851	0	PCM1	8	17872225	Frame_Shift_Ins	INS	-	TCGA-06-0192-01B-01W-0348-08		17872225	128491797	34	2538											
PRUNE2	158471	broad.mit.edu	37	chr9	79322930	79322930	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttggctgcaggttatctgcGgacatccctgtttgcacatc	10	11	1	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr9:79322930G>A	uc010mpk.2	-	8	4384	c.4260C>T	c.(4258-4260)TCC>TCT	p.S1420S		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1420					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GGTTATCTGCGGACATCCCTG	0.443													A	79322930	A	A	79322930	2	1	41	1	0	0	0	0	0	0	0	1	12641	1103	39	2		2	PRUNE2	9	79322930	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08		79322930	61890501	35	2539											
KLF6	1316	broad.mit.edu	37	chr10	3827115	3827115	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgtttacctgttgccagTactcctccagagacggcagc	10	14	0	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr10:3827115T>C	uc001iha.2	-	1	359	c.92A>G	c.(91-93)TAC>TGC	p.Y31C	KLF6_uc010qaj.1_Missense_Mutation_p.Y31C|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Missense_Mutation_p.Y31C|KLF6_uc001ihb.2_Missense_Mutation_p.Y31C	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	31					B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		CTGTTGCCAGTACTCCTCCAG	0.567													C	3827115	C	C	3827115	3	2	41	1	0	0	0	0	1	0	0	0	8350	1638	57	4	775	4	KLF6	10	3827115	Missense_Mutation	SNP	T	TCGA-06-0192-01B-01W-0348-08		3827115	131707632	36	2540											
FAM21C	253725	broad.mit.edu	37	chr10	46265058	46265058	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgatctttttgccattgcCaaggacaggtgagatagtca	11	7	2	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr10:46265058C>T	uc001jcu.2	+	20	2130	c.2031C>T	c.(2029-2031)GCC>GCT	p.A677A	FAM21C_uc001jcs.1_Silent_p.A620A|FAM21C_uc001jct.2_Silent_p.A675A|FAM21C_uc010qfi.1_Silent_p.A653A|FAM21C_uc010qfj.1_5'UTR|FAM21C_uc010qfk.1_5'UTR	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	677										ovary(1)	1						TTGCCATTGCCAAGGACAGGT	0.478													T	46265058	T	T	46265058	2	4	41	1	0	0	0	0	0	0	0	1	5542	581	21	3		3	FAM21C	10	46265058	Silent	SNP	C	TCGA-06-0192-01B-01W-0348-08	42437943	46265058	89269689	37	2541											
PTEN	5728	broad.mit.edu	37	chr10	89720794	89720794	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcagataatgacaaggaataTctagtacttactttaacaaa	6	6	1	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr10:89720794T>A	uc001kfb.2	+	9	1976	c.945T>A	c.(943-945)TAT>TAA	p.Y315*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	315	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.Y315fs*9(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.L316fs*2(1)|p.W274_F341del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ACAAGGAATATCTAGTACTTA	0.328		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89720794	A	A	89720794	4	1	41	1	0	0	0	0	0	1	0	0	12738	1442	50	5	975	5	PTEN	10	89720794	Nonsense_Mutation	SNP	T	TCGA-06-0192-01B-01W-0348-08	43455736	89720794	45813953	38	2542											
TPP1	1200	broad.mit.edu	37	chr11	6637552	6637552	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtaggaggtcacctgaggCgaagagcagggtgagacccc	18	9	1	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:6637552C>T	uc001mel.1	-	8	1130	c.1069G>A	c.(1069-1071)GCC>ACC	p.A357T	TPP1_uc001mek.1_Missense_Mutation_p.A114T	NM_000391	NP_000382	O14773	TPP1_HUMAN	tripeptidyl-peptidase I preproprotein	357					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		TCACCTGAGGCGAAGAGCAGG	0.567													T	6637552	T	T	6637552	3	4	41	1	0	0	0	0	1	0	0	0	16408	768	27	1	646	1	TPP1	11	6637552	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08		6637552	128368964	39	2543											
CTR9	9646	broad.mit.edu	37	chr11	10774300	10774300	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggaacacacacaactgcacAtatggattgctttggcggtc	10	10	0	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:10774300A>G	uc001mja.2	+	2	276	c.127A>G	c.(127-129)ATA>GTA	p.I43V		NM_014633	NP_055448	Q6PD62	CTR9_HUMAN	SH2 domain binding protein 1	43	TPR 1.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				ovary(2)	2				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		ACAACTGCACATATGGATTGC	0.363													G	10774300	G	G	10774300	3	3	41	1	0	0	0	0	1	0	0	0	4024	217	8	4	133	4	CTR9	11	10774300	Missense_Mutation	SNP	A	TCGA-06-0192-01B-01W-0348-08	4136748	10774300	124232216	40	2544											
LUZP2	338645	broad.mit.edu	37	chr11	24936063	24936063	+	Silent	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ctgaaggagcttcgttatggGaagaaggatttattatttaa	11	3	0	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:24936063G>C	uc001mqs.2	+	7	735	c.501G>C	c.(499-501)GGG>GGC	p.G167G	LUZP2_uc009yif.2_Silent_p.G81G|LUZP2_uc009yig.2_Intron	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	167	Potential.|Leucine-zipper.					extracellular region				ovary(1)|skin(1)	2						TTCGTTATGGGAAGAAGGATT	0.318													C	24936063	C	C	24936063	2	2	41	1	0	0	0	0	0	0	0	1	9087	1161	41	5		5	LUZP2	11	24936063	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	14161763	24936063	110070453	41	2545											
LRP4	4038	broad.mit.edu	37	chr11	46880714	46880714	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggcctggatggacaccgtGtctgtcttcatgcatacatg	11	11	3	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:46880714G>A	uc001ndn.3	-	38	5684	c.5538C>T	c.(5536-5538)GAC>GAT	p.D1846D	uc001ndl.2_Intron|LRP4_uc001ndm.3_Silent_p.D88D	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1846	Cytoplasmic (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		TGGACACCGTGTCTGTCTTCA	0.582													A	46880714	A	A	46880714	2	1	41	1	0	0	0	0	0	0	0	1	8959	1368	48	3		3	LRP4	11	46880714	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	21944651	46880714	88125802	42	2546											
OR5F1	338674	broad.mit.edu	37	chr11	55761167	55761167	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agccaaacaatcacagaaagGaagaggtccttttcctgcta	8	10	1	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:55761167G>A	uc010riv.1	-	1	935	c.935C>T	c.(934-936)TCC>TTC	p.S312F		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					TCACAGAAAGGAAGAGGTCCT	0.338													A	55761167	A	A	55761167	3	1	41	1	0	0	0	0	1	0	0	0	11158	1174	41	3	12	3	OR5F1	11	55761167	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	8880453	55761167	79245349	43	2547											
OR9G9	504191	broad.mit.edu	37	chr11	56468297	56468297	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gctgtgtgcattgctggtagCagtctcatattgtggtggct	14	7	1	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:56468297C>A	uc010rjn.1	+	1	434	c.434C>A	c.(433-435)GCA>GAA	p.A145E		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTGCTGGTAGCAGTCTCATAT	0.463													A	56468297	A	A	56468297	3	1	41	1	0	0	0	0	1	0	0	0	11252	710	25	5	436	5	OR9G9	11	56468297	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08	707130	56468297	78538219	44	2548											
DPF2	5977	broad.mit.edu	37	chr11	65107936	65107936	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgctgagcgcagcgtgcGcctgcctttcttggactcac	12	14	2	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:65107936G>A	uc001odm.2	+	2	125	c.113G>A	c.(112-114)CGC>CAC	p.R38H	DPF2_uc001odn.2_Missense_Mutation_p.R38H|DPF2_uc010roe.1_Missense_Mutation_p.R38H	NM_006268	NP_006259	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	38					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						CGCAGCGTGCGCCTGCCTTTC	0.552													A	65107936	A	A	65107936	3	1	41	1	0	0	0	0	1	0	0	0	4717	1087	38	1	119	1	DPF2	11	65107936	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	8639639	65107936	69898580	45	2549											
PGR	5241	broad.mit.edu	37	chr11	100999454	100999454	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cctgagggcgccaacagagtGtccaagacactgtccagcag	12	13	0	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:100999454G>C	uc001pgh.2	-	1	1091	c.348C>G	c.(346-348)GAC>GAG	p.D116E	PGR_uc001pgi.2_Missense_Mutation_p.D116E|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	116	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CCAACAGAGTGTCCAAGACAC	0.622													C	100999454	C	C	100999454	3	2	41	1	0	0	0	0	1	0	0	0	11805	1368	48	5	2485	5	PGR	11	100999454	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	35891518	100999454	34007062	46	2550											
DDI1	414301	broad.mit.edu	37	chr11	103908056	103908056	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgcaaccctcccttggcggAagccctgctcagcggaagcc	11	17	1	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:103908056A>C	uc001phr.2	+	1	749	c.506A>C	c.(505-507)GAA>GCA	p.E169A	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	169					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CCCTTGGCGGAAGCCCTGCTC	0.602													C	103908056	C	C	103908056	3	2	41	1	0	0	0	0	1	0	0	0	4328	246	9	5	508	5	DDI1	11	103908056	Missense_Mutation	SNP	A	TCGA-06-0192-01B-01W-0348-08	2908602	103908056	31098460	47	2551											
SPATA19	219938	broad.mit.edu	37	chr11	133711992	133711992	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagctgagacatctgtaagaCgggatatgctgcaggggaca	15	7	1	2	rs140608295		TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr11:133711992C>T	uc001qgv.1	-	6	497	c.446G>A	c.(445-447)CGT>CAT	p.R149H		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	149					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		ATCTGTAAGACGGGATATGCT	0.602													T	133711992	T	T	133711992	3	4	41	1	0	0	0	0	1	0	0	0	15003	536	19	1	61	1	SPATA19	11	133711992	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08	29803936	133711992	1294524	48	2552											
CLEC1A	51267	broad.mit.edu	37	chr12	10241786	10241786	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaagtcagcagggtcagggCcactggtcgccacgttgaag	14	11	2	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr12:10241786C>T	uc001qxb.2	-	2	235	c.151G>A	c.(151-153)GCC>ACC	p.A51T	CLEC1A_uc009zhf.2_5'UTR|CLEC1A_uc001qxc.2_5'UTR|CLEC1A_uc001qxd.2_Intron|CLEC1A_uc010sgx.1_Intron	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1	51	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2						AGGGTCAGGGCCACTGGTCGC	0.547													T	10241786	T	T	10241786	3	4	41	1	0	0	0	0	1	0	0	0	3505	739	26	3	711	3	CLEC1A	12	10241786	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08		10241786	123610109	49	2553											
LST-3TM12	338821	broad.mit.edu	37	chr12	21168708	21168708	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtttaattgatggaagcttcGaaataggtagctttttattt	9	3	0	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr12:21168708G>A	uc010sin.1	+	1	79	c.79G>A	c.(79-81)GAA>AAA	p.E27K	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Intron	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	27						membrane	transporter activity				0						TGGAAGCTTCGAAATAGGTAG	0.244													A	21168708	A	A	21168708	3	1	41	1	0	0	0	0	1	0	0	0	9066	1059	37	2	81	2	LST-3TM12	12	21168708	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	10926922	21168708	112683187	50	2554											
ABCC9	10060	broad.mit.edu	37	chr12	22005399	22005399	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaatcccctcctgcattaaaTgatcactcaagtgaatgtcc	5	12	2	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr12:22005399T>C	uc001rfi.1	-	21	2566	c.2546A>G	c.(2545-2547)CAT>CGT	p.H849R	ABCC9_uc001rfh.2_Missense_Mutation_p.H849R|ABCC9_uc001rfj.1_Missense_Mutation_p.H813R	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	849	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTGCATTAAATGATCACTCAA	0.403													C	22005399	C	C	22005399	3	2	41	1	0	0	0	0	1	0	0	0	59	1464	51	4	2317	4	ABCC9	12	22005399	Missense_Mutation	SNP	T	TCGA-06-0192-01B-01W-0348-08	836691	22005399	111846496	51	2555											
ARNTL2	56938	broad.mit.edu	37	chr12	27521311	27521311	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacacatgacagagtttccaCgaaaacgcaaaggaagtgat	9	9	0	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr12:27521311C>T	uc001rht.1	+	2	166	c.148C>T	c.(148-150)CGA>TGA	p.R50*	ARNTL2_uc001rhw.2_Nonsense_Mutation_p.R61*|ARNTL2_uc010sjp.1_Nonsense_Mutation_p.R61*|ARNTL2_uc001rhu.1_Nonsense_Mutation_p.R50*|ARNTL2_uc009zji.1_Nonsense_Mutation_p.R50*|ARNTL2_uc001rhv.1_Nonsense_Mutation_p.R50*	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	50					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					AGAGTTTCCACGAAAACGCAA	0.483													T	27521311	T	T	27521311	4	4	41	1	0	0	0	0	0	1	0	0	968	528	19	1	154	1	ARNTL2	12	27521311	Nonsense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08	5515912	27521311	106330584	52	2556											
ASB8	140461	broad.mit.edu	37	chr12	48543629	48543629	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcccgcacacactcagcattGttcttaaaggctgcccagtg	9	14	2	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr12:48543629G>T	uc001rrh.2	-	4	556	c.387C>A	c.(385-387)AAC>AAA	p.N129K	ASB8_uc010slr.1_Missense_Mutation_p.N125K	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	129	ANK 3.				intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						ACTCAGCATTGTTCTTAAAGG	0.527													T	48543629	T	T	48543629	3	4	41	1	0	0	0	0	1	0	0	0	1029	1368	48	5	483	5	ASB8	12	48543629	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	21022318	48543629	85308266	53	2557											
SMARCC2	6601	broad.mit.edu	37	chr12	56563342	56563342	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgcggcggcggccagggCggcggcagcagcggtggaga	21	12	0	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr12:56563342C>T	uc001skb.2	-	24	2699	c.2593G>A	c.(2593-2595)GCC>ACC	p.A865T	SMARCC2_uc001skd.2_Missense_Mutation_p.A896T|SMARCC2_uc001ska.2_Missense_Mutation_p.A896T|SMARCC2_uc001skc.2_Missense_Mutation_p.A895T|SMARCC2_uc010sqf.1_Missense_Mutation_p.A785T	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	865	Poly-Ala.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			gcggccagggcggcggcagca	0.244													T	56563342	T	T	56563342	3	4	41	1	0	0	0	0	1	0	0	0	14776	768	27	1	1071	1	SMARCC2	12	56563342	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08	8019713	56563342	77288553	54	2558											
FGD6	55785	broad.mit.edu	37	chr12	95603382	95603382	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactggcttttctgaagcccGtttaggcatatcaaaggagg	11	9	2	1	rs149076340	byFrequency	TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr12:95603382G>A	uc001tdp.3	-	2	1902	c.1678C>T	c.(1678-1680)CGG>TGG	p.R560W	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	560					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						TCTGAAGCCCGTTTAGGCATA	0.423													A	95603382	A	A	95603382	3	1	41	1	0	0	0	0	1	0	0	0	5837	1144	40	1	2694	1	FGD6	12	95603382	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	39040040	95603382	38248513	55	2559											
CDK17	5128	broad.mit.edu	37	chr12	96688901	96688901	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agaatttggtacagaaacagCtacagaaacaaataaataaa	6	5	0	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr12:96688901C>G	uc001tep.1	-	10	1363	c.874_splice	c.e10-1	p.L292_splice	CDK17_uc009ztk.2_Splice_Site_p.L292_splice|CDK17_uc010svb.1_Splice_Site_p.L239_splice	NM_002595	NP_002586	Q00537	CDK17_HUMAN	PCTAIRE protein kinase 2								ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7						ACAGAAACAGCTACAGAAACA	0.358													G	96688901	G	G	96688901	5	3	41	1	0	0	0	0	0	0	1	0	3133	811	28	5	768	5	CDK17	12	96688901	Splice_Site	SNP	C	TCGA-06-0192-01B-01W-0348-08	1085519	96688901	37162994	56	2560											
ZIC2	7546	broad.mit.edu	37	chr13	100634942	100634942	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgacccctactcggcggcGcaactccacaaccagtacgg	9	18	0	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr13:100634942G>A	uc001von.2	+	1	624	c.624G>A	c.(622-624)GCG>GCA	p.A208A		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	208	Necessary for interaction with MDFIC and transcriptional activation or repression (By similarity).				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACTCGGCGGCGCAACTCCACA	0.577													A	100634942	A	A	100634942	2	1	41	1	0	0	0	0	0	0	0	1	17676	1074	38	1		1	ZIC2	13	100634942	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08		100634942	14534936	57	2561											
MDGA2	161357	broad.mit.edu	37	chr14	47530541	47530541	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtgtacgtcccaaaatccGtgaattttaaatcaatgatg	7	7	1	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr14:47530541G>A	uc001wwj.3	-	7	1425	c.1229C>T	c.(1228-1230)ACG>ATG	p.T410M	MDGA2_uc001wwi.3_Missense_Mutation_p.T181M|MDGA2_uc010ani.2_Translation_Start_Site	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	410	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CCCAAAATCCGTGAATTTTAA	0.428													A	47530541	A	A	47530541	3	1	41	1	0	0	0	0	1	0	0	0	9407	1145	40	1	1685	1	MDGA2	14	47530541	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08		47530541	59818999	58	2562											
OR4N4	283694	broad.mit.edu	37	chr15	22382513	22382513	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agtagtgacagaatttatccTccttggtctgactcagtctc	8	10	3	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr15:22382513T>A	uc001yuc.1	+	7	1022	c.41T>A	c.(40-42)CTC>CAC	p.L14H	LOC727924_uc001yub.1_RNA|OR4N4_uc010tzv.1_Missense_Mutation_p.L14H	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GAATTTATCCTCCTTGGTCTG	0.343													A	22382513	A	A	22382513	3	1	41	1	0	0	0	0	1	0	0	0	11078	1551	54	5	43	5	OR4N4	15	22382513	Missense_Mutation	SNP	T	TCGA-06-0192-01B-01W-0348-08		22382513	80148879	59	2563											
GABRB3	2562	broad.mit.edu	37	chr15	26812854	26812854	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatgttcctcttcaaccgaaAgctcagtgacagtcgaggat	9	10	3	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr15:26812854A>G	uc001zaz.2	-	7	851	c.709T>C	c.(709-711)TTT>CTT	p.F237L	GABRB3_uc010uae.1_Missense_Mutation_p.F152L|GABRB3_uc001zba.2_Missense_Mutation_p.F237L|GABRB3_uc001zbb.2_Missense_Mutation_p.F293L	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	237	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTCAACCGAAAGCTCAGTGAC	0.418													G	26812854	G	G	26812854	3	3	41	1	0	0	0	0	1	0	0	0	6168	72	3	4	724	4	GABRB3	15	26812854	Missense_Mutation	SNP	A	TCGA-06-0192-01B-01W-0348-08	4430341	26812854	75718538	60	2564											
TTBK2	146057	broad.mit.edu	37	chr15	43038437	43038437	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcggagttactactccctagGactttatatctgcgtagcct	8	11	1	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr15:43038437G>A	uc001zqo.2	-	15	3730	c.3291C>T	c.(3289-3291)GTC>GTT	p.V1097V	TTBK2_uc010bcy.2_Silent_p.V1028V|uc001zqn.2_5'Flank	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1097					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		TACTCCCTAGGACTTTATATC	0.393													A	43038437	A	A	43038437	2	1	41	1	0	0	0	0	0	0	0	1	16674	1161	41	3		3	TTBK2	15	43038437	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	16225583	43038437	59492955	61	2565											
USP50	373509	broad.mit.edu	37	chr15	50838708	50838708	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtcatctgcagggagagaCggctgagaagtcattttaat	12	6	3	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr15:50838708C>T	uc001zyq.3	-	1	195	c.15G>A	c.(13-15)CCG>CCA	p.P5P		NM_203494	NP_987090	E9PP86	E9PP86_HUMAN	ubiquitin specific protease 50	5					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			lung(1)|breast(1)	2				all cancers(107;0.000519)|GBM - Glioblastoma multiforme(94;0.00288)		CAGGGAGAGACGGCTGAGAAG	0.453													T	50838708	T	T	50838708	2	4	41	1	0	0	0	0	0	0	0	1	17079	523	19	1		1	USP50	15	50838708	Silent	SNP	C	TCGA-06-0192-01B-01W-0348-08	7800271	50838708	51692684	62	2566											
GRIN2A	2903	broad.mit.edu	37	chr16	9858210	9858210	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcacgtggcccgatttgacGtttctgaaatgtcagagtgg	14	8	2	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr16:9858210G>A	uc002czo.3	-	13	3739	c.3191C>T	c.(3190-3192)ACG>ATG	p.T1064M	GRIN2A_uc010uym.1_Missense_Mutation_p.T1064M|GRIN2A_uc010uyn.1_Missense_Mutation_p.T907M|GRIN2A_uc002czr.3_Missense_Mutation_p.T1064M	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1064	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCGATTTGACGTTTCTGAAAT	0.507													A	9858210	A	A	9858210	3	1	41	1	0	0	0	0	1	0	0	0	6779	1145	40	1	1207	1	GRIN2A	16	9858210	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08		9858210	80496543	63	2567											
HERPUD1	9709	broad.mit.edu	37	chr16	56973164	56973164	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tataggcctgaagctgcccaGcaggcattccaaggcctggg	13	12	0	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr16:56973164G>A	uc002eke.1	+	5	856	c.447G>A	c.(445-447)CAG>CAA	p.Q149Q	HERPUD1_uc002ekf.1_Silent_p.Q148Q|HERPUD1_uc002ekg.1_Silent_p.Q124Q|HERPUD1_uc010cco.1_Silent_p.Q210Q|HERPUD1_uc010ccp.1_Intron|HERPUD1_uc002ekh.1_5'UTR	NM_014685	NP_055500	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum	149	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0						AAGCTGCCCAGCAGGCATTCC	0.423			T	ERG	prostate								A	56973164	A	A	56973164	2	1	41	1	0	0	0	0	0	0	0	1	7063	962	34	3		3	HERPUD1	16	56973164	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	47114954	56973164	33381589	64	2568											
TAT	6898	broad.mit.edu	37	chr16	71603782	71603782	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtacatagccccagaagggCggactggccggagtccaggg	17	11	0	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr16:71603782C>T	uc002fap.2	-	10	1199	c.1100G>A	c.(1099-1101)CGC>CAC	p.R367H		NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	367					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CCCAGAAGGGCGGACTGGCCG	0.512													T	71603782	T	T	71603782	3	4	41	1	0	0	0	0	1	0	0	0	15587	768	27	1	276	1	TAT	16	71603782	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08	14630618	71603782	18750971	65	2569											
NF1	4763	broad.mit.edu	37	chr17	29677208	29677209	+	Frame_Shift_Ins	INS	-	A	A													ttttccttttagctttacttINSacagtgtctgaagaagttcg							TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr17:29677208_29677209insA	uc002hgg.2	+	50	7662_7663	c.7329_7330insA	c.(7327-7332)CTTACAfs	p.L2443fs	NF1_uc002hgh.2_Frame_Shift_Ins_p.L2422fs|NF1_uc010cso.2_Frame_Shift_Ins_p.L631fs|NF1_uc010wbt.1_5'UTR|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2443_2444					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TAGCTTTACTTACAGTGTCTGA	0.356			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29677209	A	A	29677208	7	5	41	1	0	1	1	0	0	0	0	0	10356	1741	61	0	7588	0	NF1	17	29677208	Frame_Shift_Ins	INS	-	TCGA-06-0192-01B-01W-0348-08		29677208	51518002	66	2570											
MYO1D	4642	broad.mit.edu	37	chr17	31105570	31105570	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taatgtacttactggcttccGttttaccagctccactttcc	5	13	0	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr17:31105570G>A	uc002hho.1	-	3	338	c.326C>T	c.(325-327)ACG>ATG	p.T109M	MYO1D_uc002hhp.1_Missense_Mutation_p.T109M|MYO1D_uc010wcb.1_Missense_Mutation_p.T109M	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	109	ATP (Potential).|Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			ACTGGCTTCCGTTTTACCAGC	0.393													A	31105570	A	A	31105570	3	1	41	1	0	0	0	0	1	0	0	0	10071	1145	40	1	2774	1	MYO1D	17	31105570	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	1428362	31105570	50089640	67	2571											
HOXB13	10481	broad.mit.edu	37	chr17	46804366	46804366	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcgtttcttgcggccgcgaCgaaaggcgcaggcgtcagga	16	11	2	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr17:46804366C>T	uc002ioa.2	-	2	797	c.641G>A	c.(640-642)CGT>CAT	p.R214H	hsa-mir-3185|MI0014227_5'Flank	NM_006361	NP_006352	Q92826	HXB13_HUMAN	homeobox B13	214					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCGGCCGCGACGAAAGGCGCA	0.622													T	46804366	T	T	46804366	3	4	41	1	0	0	0	0	1	0	0	0	7300	536	19	1	217	1	HOXB13	17	46804366	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08	15698796	46804366	34390844	68	2572											
ANKRD30B	374860	broad.mit.edu	37	chr18	14851607	14851607	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaagtagccacactgaaaCatcaacaccaggtgaaggaa	10	9	1	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr18:14851607C>T	uc010dlo.2	+	36	3487	c.3307C>T	c.(3307-3309)CAT>TAT	p.H1103Y	ANKRD30B_uc010xal.1_Missense_Mutation_p.H245Y	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1188	Potential.									ovary(1)|skin(1)	2						CACACTGAAACATCAACACCA	0.343													T	14851607	T	T	14851607	3	4	41	1	0	0	0	0	1	0	0	0	659	478	17	3	3449	3	ANKRD30B	18	14851607	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08		14851607	63225641	69	2573											
DSG3	1830	broad.mit.edu	37	chr18	29052301	29052301	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggttctactgggggagTgacaggtggttttatcccag	16	7	1	1	rs113457225		TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr18:29052301T>A	uc002kws.2	+	13	2061	c.1952T>A	c.(1951-1953)GTG>GAG	p.V651E	DSG3_uc002kwt.2_5'Flank	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	651	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACTGGGGGAGTGACAGGTGGT	0.478													A	29052301	A	A	29052301	3	1	41	1	0	0	0	0	1	0	0	0	4778	1696	59	5	2002	5	DSG3	18	29052301	Missense_Mutation	SNP	T	TCGA-06-0192-01B-01W-0348-08	14200694	29052301	49024947	70	2574											
LPHN1	22859	broad.mit.edu	37	chr19	14261968	14261968	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctggcatagagggagtccCggccaggaggggaggagagg	21	8	0	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr19:14261968C>T	uc010xnn.1	-	24	4438	c.4142G>A	c.(4141-4143)CGG>CAG	p.R1381Q	LPHN1_uc010xno.1_Missense_Mutation_p.R1376Q|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	1381	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						GAGGGAGTCCCGGCCAGGAGG	0.731													T	14261968	T	T	14261968	3	4	41	1	0	0	0	0	1	0	0	0	8915	652	23	2	286	2	LPHN1	19	14261968	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08		14261968	44867015	71	2575											
CYP4F3	4051	broad.mit.edu	37	chr19	15770048	15770048	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaactgcatcgggcaggcGttcgcgatggcggagatgaa	17	8	0	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr19:15770048G>A	uc002nbj.2	+	13	1466	c.1416G>A	c.(1414-1416)GCG>GCA	p.A472A	CYP4F3_uc010xok.1_Silent_p.A472A|CYP4F3_uc010xol.1_Silent_p.A472A|CYP4F3_uc010xom.1_Silent_p.A323A|CYP4F3_uc002nbk.2_Silent_p.A472A|CYP4F3_uc010xon.1_Silent_p.A182A	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	472					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TCGGGCAGGCGTTCGCGATGG	0.672													A	15770048	A	A	15770048	2	1	41	1	0	0	0	0	0	0	0	1	4190	1132	40	1		1	CYP4F3	19	15770048	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	1508080	15770048	43358935	72	2576											
CYP4F2	8529	broad.mit.edu	37	chr19	15989728	15989728	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcatctccgccatcgcgaaCgtctgcccgatgcagttcct	8	16	3	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr19:15989728C>T	uc002nbs.1	-	13	1466	c.1416G>A	c.(1414-1416)ACG>ACA	p.T472T	CYP4F2_uc010xot.1_Silent_p.T323T	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	472					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CCATCGCGAACGTCTGCCCGA	0.672													T	15989728	T	T	15989728	2	4	41	1	0	0	0	0	0	0	0	1	4188	523	19	1		1	CYP4F2	19	15989728	Silent	SNP	C	TCGA-06-0192-01B-01W-0348-08	219680	15989728	43139255	73	2577											
ZNF430	80264	broad.mit.edu	37	chr19	21239692	21239692	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttataaattttcaaatccaaAtatacaaaagataagacata	2	5	1	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr19:21239692A>G	uc002npj.2	+	5	688	c.578A>G	c.(577-579)AAT>AGT	p.N193S	ZNF430_uc002npk.2_Missense_Mutation_p.N192S	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						TCAAATCCAAATATACAAAAG	0.279													G	21239692	G	G	21239692	3	3	41	1	0	0	0	0	1	0	0	0	17901	101	4	4	596	4	ZNF430	19	21239692	Missense_Mutation	SNP	A	TCGA-06-0192-01B-01W-0348-08	5249964	21239692	37889291	74	2578											
IRGC	56269	broad.mit.edu	37	chr19	44223553	44223553	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgtcatccaggccctgccGgtcccagggctggcggccgc	16	17	1	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr19:44223553G>A	uc002oxh.2	+	2	990	c.843G>A	c.(841-843)CCG>CCA	p.P281P		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	281						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				AGGCCCTGCCGGTCCCAGGGC	0.632													A	44223553	A	A	44223553	2	1	41	1	0	0	0	0	0	0	0	1	7838	1103	39	2		2	IRGC	19	44223553	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	22983861	44223553	14905430	75	2579											
ZNF296	162979	broad.mit.edu	37	chr19	45575604	45575605	+	Frame_Shift_Ins	INS	-	G	G													aggacaggtggggctccgccINSgggtgaggccgctgccactt							TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr19:45575604_45575605insG	uc002pao.2	-	3	739_740	c.682_683insC	c.(682-684)CGGfs	p.R228fs		NM_145288	NP_660331	Q8WUU4	ZN296_HUMAN	zinc finger protein 296	228					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGGCTCCGCCGGGTGAGGCCG	0.678													G	45575605	G	G	45575604	7	5	41	1	0	1	1	0	0	0	0	0	17825	652	23	0	748	0	ZNF296	19	45575604	Frame_Shift_Ins	INS	-	TCGA-06-0192-01B-01W-0348-08	1352051	45575604	13553379	76	2580											
PLCG1	5335	broad.mit.edu	37	chr20	39801169	39801169	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaagttccttcagtacaatcGactgcagctctcccgcatct	7	14	3	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr20:39801169G>A	uc002xjp.1	+	26	3135	c.3014G>A	c.(3013-3015)CGA>CAA	p.R1005Q	PLCG1_uc002xjo.1_Missense_Mutation_p.R1005Q|PLCG1_uc010zwe.1_Missense_Mutation_p.R631Q	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	1005	PI-PLC Y-box.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				CAGTACAATCGACTGCAGCTC	0.542													A	39801169	A	A	39801169	3	1	41	1	0	0	0	0	1	0	0	0	12035	1058	37	2	3116	2	PLCG1	20	39801169	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08		39801169	23224351	77	2581											
TMPRSS15	5651	broad.mit.edu	37	chr21	19647560	19647560	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	catagcctgcacatatcataTtttcagtaatgttatattct	4	8	3	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr21:19647560T>A	uc002ykw.2	-	24	2889	c.2858A>T	c.(2857-2859)AAT>ATT	p.N953I		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	953	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						ACATATCATATTTTCAGTAAT	0.383													A	19647560	A	A	19647560	3	1	41	1	0	0	0	0	1	0	0	0	16243	1493	52	5	209	5	TMPRSS15	21	19647560	Missense_Mutation	SNP	T	TCGA-06-0192-01B-01W-0348-08		19647560	28482335	78	2582											
MX2	4600	broad.mit.edu	37	chr21	42778692	42778692	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacgattgaagacataaaaGtgaaacacacagcaaaggca	9	8	0	3			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr21:42778692G>A	uc002yzf.1	+	13	1776	c.1672G>A	c.(1672-1674)GTG>ATG	p.V558M	MX2_uc002yzg.1_Missense_Mutation_p.V281M|MX2_uc010gop.1_Missense_Mutation_p.V40M	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	558					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AGACATAAAAGTGAAACACAC	0.343													A	42778692	A	A	42778692	3	1	41	1	0	0	0	0	1	0	0	0	9998	1029	36	3	1718	3	MX2	21	42778692	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	23131132	42778692	5351203	79	2583											
KRTAP10-3	386682	broad.mit.edu	37	chr21	45978487	45978487	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcaggcagggggccggggCgcagcagctggtggcgcagc	22	11	1	0			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr21:45978487C>T	uc002zfj.1	-	1	157	c.112G>A	c.(112-114)GCC>ACC	p.A38T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198696	NP_941969	P60369	KR103_HUMAN	keratin associated protein 10-3	38	3.|18 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						GGGGCCGGGGCGCAGCAGCTG	0.697													T	45978487	T	T	45978487	3	4	41	1	0	0	0	0	1	0	0	0	8510	768	27	1	557	1	KRTAP10-3	21	45978487	Missense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08	3199795	45978487	2151408	80	2584											
GAL3ST1	9514	broad.mit.edu	37	chr22	30951019	30951019	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgaggtccatcaggtactggAtctcgggcgtgagcatgcgc	15	11	2	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chr22:30951019A>C	uc003aig.1	-	4	1333	c.1193T>G	c.(1192-1194)ATC>AGC	p.I398S	GAL3ST1_uc003aih.1_Missense_Mutation_p.I398S|GAL3ST1_uc003aii.1_Missense_Mutation_p.I398S|GAL3ST1_uc010gvz.1_Missense_Mutation_p.I398S	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	398	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CAGGTACTGGATCTCGGGCGT	0.642													C	30951019	C	C	30951019	3	2	41	1	0	0	0	0	1	0	0	0	6197	333	12	5	82	5	GAL3ST1	22	30951019	Missense_Mutation	SNP	A	TCGA-06-0192-01B-01W-0348-08		30951019	20353547	81	2585											
CYBB	1536	broad.mit.edu	37	chrX	37663372	37663372	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caggagtttcaagatgcgtgGaaactacctaagtgagtaaa	11	6	1	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chrX:37663372G>A	uc004ddr.2	+	9	1201	c.1140G>A	c.(1138-1140)TGG>TGA	p.W380*	CYBB_uc011mke.1_RNA|CYBB_uc011mkf.1_Nonsense_Mutation_p.W348*|CYBB_uc011mkg.1_Nonsense_Mutation_p.W113*	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	380	Cytoplasmic (Potential).|FAD-binding FR-type.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						AAGATGCGTGGAAACTACCTA	0.423													A	37663372	A	A	37663372	4	1	41	1	0	0	0	0	0	1	0	0	4133	1183	41	3	1174	3	CYBB	23	37663372	Nonsense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08		37663372	117607188	82	2586											
ZCCHC5	203430	broad.mit.edu	37	chrX	77913863	77913863	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccactgcacttgagcctgccGaatttcattctccaatttca	5	14	3	1	rs148985625		TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chrX:77913863G>A	uc004edc.1	-	2	351	c.55C>T	c.(55-57)CGG>TGG	p.R19W		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	19							nucleic acid binding|zinc ion binding			ovary(1)	1						TGAGCCTGCCGAATTTCATTC	0.463													A	77913863	A	A	77913863	3	1	41	1	0	0	0	0	1	0	0	0	17588	1057	37	2	1376	2	ZCCHC5	23	77913863	Missense_Mutation	SNP	G	TCGA-06-0192-01B-01W-0348-08	40250491	77913863	77356697	83	2587											
GPR174	84636	broad.mit.edu	37	chrX	78426556	78426556	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atggagacaatacagattttCgatactttatttatgcagtg	8	5	0	2			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chrX:78426556C>T	uc004edg.1	+	1	88	c.52C>T	c.(52-54)CGA>TGA	p.R18*		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	18	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						TACAGATTTTCGATACTTTAT	0.383										HNSCC(63;0.18)			T	78426556	T	T	78426556	4	4	41	1	0	0	0	0	0	1	0	0	6672	876	31	2	54	2	GPR174	23	78426556	Nonsense_Mutation	SNP	C	TCGA-06-0192-01B-01W-0348-08	512693	78426556	76844004	84	2588											
NKAP	79576	broad.mit.edu	37	chrX	119077554	119077554	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctatccgggctgcgtgagccGgacaccggagccatggctac	14	14	0	1			TCGA-06-0192-01B-01W-0348-08	TCGA-06-0192-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	43d7bc6f-be9b-4d5e-bcec-4fb30b0d9b65	e41ffe0e-8035-42d4-b889-a3e81b62bf00	g.chrX:119077554G>A	uc004esh.2	-	1	182	c.15C>T	c.(13-15)TCC>TCT	p.S5S		NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	5	Ser-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						TGCGTGAGCCGGACACCGGAG	0.692													A	119077554	A	A	119077554	2	1	41	1	0	0	0	0	0	0	0	1	10439	1103	39	2		2	NKAP	23	119077554	Silent	SNP	G	TCGA-06-0192-01B-01W-0348-08	40650998	119077554	36193006	85	2589											
GJB5	2709	broad.mit.edu	37	chr1	35223555	35223555	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgtggagctcatctacctGgtgagcaagagatgccacga	12	11	2	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr1:35223555G>A	uc001bxu.2	+	2	724	c.624G>A	c.(622-624)CTG>CTA	p.L208L	GJB4_uc001bxv.1_5'Flank	NM_005268	NP_005259	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	208	Helical; (Potential).				cell communication|epidermis development	connexon complex|integral to membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)				TCATCTACCTGGTGAGCAAGA	0.552													A	35223555	A	A	35223555	2	1	42	1	0	0	0	0	0	0	0	1	6411	1335	47	3		3	GJB5	1	35223555	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08		35223555	214027066	1	2590											
DMAP1	55929	broad.mit.edu	37	chr1	44684377	44684377	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatttgatgctgggcacgaaCgacggcggaaggaacagctt	14	8	0	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr1:44684377C>T	uc001clq.1	+	6	750	c.670C>T	c.(670-672)CGA>TGA	p.R224*	DMAP1_uc010okt.1_3'UTR|DMAP1_uc001clr.1_Nonsense_Mutation_p.R224*|DMAP1_uc001cls.1_Nonsense_Mutation_p.R224*|DMAP1_uc010oku.1_Nonsense_Mutation_p.R214*	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	224					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					TGGGCACGAACGACGGCGGAA	0.572											OREG0013437	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	44684377	T	T	44684377	4	4	42	1	0	0	0	0	0	1	0	0	4576	528	19	1	688	1	DMAP1	1	44684377	Nonsense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	9460822	44684377	204566244	2	2591											
FLG	2312	broad.mit.edu	37	chr1	152286042	152286042	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtctcagcccagcctttccGtggcctgacactgattgtgt	10	13	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr1:152286042G>A	uc001ezu.1	-	3	1356	c.1320C>T	c.(1318-1320)CAC>CAT	p.H440H	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	440	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGCCTTTCCGTGGCCTGACA	0.592									Ichthyosis				A	152286042	A	A	152286042	2	1	42	1	0	0	0	0	0	0	0	1	5922	1136	40	1		1	FLG	1	152286042	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08	107601665	152286042	96964579	3	2592											
NES	10763	broad.mit.edu	37	chr1	156640774	156640774	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caccccctggggccacatcaTcttccaccaggggctctatc	8	18	3	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr1:156640774T>A	uc001fpq.2	-	4	3339	c.3206A>T	c.(3205-3207)GAT>GTT	p.D1069V		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1069	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGCCACATCATCTTCCACCAG	0.682													A	156640774	A	A	156640774	3	1	42	1	0	0	0	0	1	0	0	0	10337	1435	50	5	1663	5	NES	1	156640774	Missense_Mutation	SNP	T	TCGA-06-0195-01B-01D-1491-08	4354732	156640774	92609847	4	2593											
C1orf129	80133	broad.mit.edu	37	chr1	170961421	170961421	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaatggaggacaccgtaaCggaagggaaacgtttctctc	13	8	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr1:170961421C>T	uc001ghg.2	+	12	1275	c.1145C>T	c.(1144-1146)ACG>ATG	p.T382M	C1orf129_uc009wvy.2_Missense_Mutation_p.T189M|C1orf129_uc010plz.1_Missense_Mutation_p.T382M	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	382							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GACACCGTAACGGAAGGGAAA	0.468													T	170961421	T	T	170961421	3	4	42	1	0	0	0	0	1	0	0	0	1996	536	19	1	1187	1	C1orf129	1	170961421	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	14320647	170961421	78289200	5	2594											
LHX9	56956	broad.mit.edu	37	chr1	197896816	197896816	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tgcgaacctctttcaagcatCaccagctccggaccatgaaa	7	14	3	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr1:197896816C>A	uc001guk.1	+	4	1266	c.829C>A	c.(829-831)CAC>AAC	p.H277N	LHX9_uc001gui.1_Missense_Mutation_p.H268N|LHX9_uc001guj.1_Missense_Mutation_p.H283N	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	277	Homeobox.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						TTTCAAGCATCACCAGCTCCG	0.527													A	197896816	A	A	197896816	3	1	42	1	0	0	0	0	1	0	0	0	8777	826	29	5	875	5	LHX9	1	197896816	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	26935395	197896816	51353805	6	2595											
PCNXL2	80003	broad.mit.edu	37	chr1	233394108	233394108	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cccaccttagactcggagccTgtatcaggtgtaagccggga	12	12	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr1:233394108T>C	uc001hvl.2	-	5	1735	c.1500A>G	c.(1498-1500)ACA>ACG	p.T500T	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	500						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				ACTCGGAGCCTGTATCAGGTG	0.562													C	233394108	C	C	233394108	2	2	42	1	0	0	0	0	0	0	0	1	11592	1567	55	4		4	PCNXL2	1	233394108	Silent	SNP	T	TCGA-06-0195-01B-01D-1491-08	35497292	233394108	15856513	7	2596											
GPR75	10936	broad.mit.edu	37	chr2	54080319	54080320	+	In_Frame_Ins	INS	-	TGCACTAAG	TGCACTAAG													ctgaagtgctgtcatattccINStgcactaagtcattagtggt							TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr2:54080319_54080320insTGCACTAAG	uc002rxo.3	-	2	1845_1846	c.1574_1575insCTTAGTGCA	c.(1573-1575)CAG>CACTTAGTGCAG	p.524_525insHLV	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	524_525	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TGTCATATTCCTGCACTAAGTC	0.411													TGCACTAAG	54080320	TGCACTAAG	TGCACTAAG	54080319	7	5	42	1	0	1	1	0	0	0	0	0	6708	680	24	0	51	0	GPR75	2	54080319	In_Frame_Ins	INS	-	TCGA-06-0195-01B-01D-1491-08		54080319	189119054	8	2597											
CEP68	23177	broad.mit.edu	37	chr2	65309696	65309696	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggatgtccttgggaggatcGcaaagcagtctggtgagctg	16	7	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr2:65309696G>A	uc002sdl.3	+	6	2345	c.2131G>A	c.(2131-2133)GCA>ACA	p.A711T	CEP68_uc010yqb.1_3'UTR|CEP68_uc002sdk.3_Missense_Mutation_p.A574T|CEP68_uc010yqc.1_Missense_Mutation_p.A711T	NM_015147	NP_055962	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	711					centrosome organization	centrosome				skin(1)	1						TGGGAGGATCGCAAAGCAGTC	0.463													A	65309696	A	A	65309696	3	1	42	1	0	0	0	0	1	0	0	0	3258	1087	38	1	2149	1	CEP68	2	65309696	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	11229377	65309696	177889677	9	2598											
TTN	7273	broad.mit.edu	37	chr2	179589211	179589211	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttacactccagagtgcacGtttctcctacagtcaccgtc	6	16	2	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr2:179589211G>A	uc010zfg.1	-	69	17383	c.17159C>T	c.(17158-17160)ACG>ATG	p.T5720M	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T2381M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6647							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAGTGCACGTTTCTCCTAC	0.478													A	179589211	A	A	179589211	3	1	42	1	0	0	0	0	1	0	0	0	16732	1145	40	1	83802	1	TTN	2	179589211	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	114279515	179589211	63610162	10	2599											
TTN	7273	broad.mit.edu	37	chr2	179637967	179637967	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttcaattttatatttagaaCtgggcttgatttccttgtcc	6	8	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr2:179637967C>A	uc010zfg.1	-	33	7948	c.7724G>T	c.(7723-7725)AGT>ATT	p.S2575I	TTN_uc010zfh.1_Missense_Mutation_p.S2529I|TTN_uc010zfi.1_Missense_Mutation_p.S2529I|TTN_uc010zfj.1_Missense_Mutation_p.S2529I|TTN_uc002unb.2_Missense_Mutation_p.S2575I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2575							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATTTAGAACTGGGCTTGAT	0.353													A	179637967	A	A	179637967	3	1	42	1	0	0	0	0	1	0	0	0	16732	565	20	5	103584	5	TTN	2	179637967	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	48756	179637967	63561406	11	2600											
CCDC141	285025	broad.mit.edu	37	chr2	179701794	179701794	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttctcgaggaaccatttgCctctgatagcccctgctggt	9	13	3	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr2:179701794C>T	uc002unf.1	-	13	2484	c.2427G>A	c.(2425-2427)AGG>AGA	p.R809R	CCDC141_uc002une.1_Silent_p.R259R	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	809							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GAACCATTTGCCTCTGATAGC	0.493													T	179701794	T	T	179701794	2	4	42	1	0	0	0	0	0	0	0	1	2775	738	26	3		3	CCDC141	2	179701794	Silent	SNP	C	TCGA-06-0195-01B-01D-1491-08	63827	179701794	63497579	12	2601											
MPP4	58538	broad.mit.edu	37	chr2	202557686	202557686	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gatcgtacaagagacacactCcattcacatctctgccgtag	7	13	2	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr2:202557686C>A	uc002uyk.3	-	3	354	c.146G>T	c.(145-147)GGA>GTA	p.G49V	MPP4_uc010ftj.2_Missense_Mutation_p.G49V|MPP4_uc010zhq.1_Missense_Mutation_p.G49V|MPP4_uc010zhr.1_Missense_Mutation_p.G49V|MPP4_uc010zhs.1_Missense_Mutation_p.G49V|MPP4_uc002uyj.3_Missense_Mutation_p.G49V|MPP4_uc010zht.1_Missense_Mutation_p.G49V|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Missense_Mutation_p.G49V|MPP4_uc002uym.1_Missense_Mutation_p.G62V|MPP4_uc002uyn.2_Missense_Mutation_p.G49V	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	49	L27 1.					cytoplasm	protein binding				0						GAGACACACTCCATTCACATC	0.547													A	202557686	A	A	202557686	3	1	42	1	0	0	0	0	1	0	0	0	9736	855	30	5	1847	5	MPP4	2	202557686	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	22855892	202557686	40641687	13	2602											
DIS3L2	129563	broad.mit.edu	37	chr2	233028324	233028324	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aattccaccagaggagttcaGcaagagaagggatttaaggt	12	6	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr2:233028324G>T	uc010fxz.2	+	9	1382	c.1106G>T	c.(1105-1107)AGC>ATC	p.S369I	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	369							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		GAGGAGTTCAGCAAGAGAAGG	0.433													T	233028324	T	T	233028324	3	4	42	1	0	0	0	0	1	0	0	0	4537	971	34	5	1136	5	DIS3L2	2	233028324	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	30470638	233028324	10171049	14	2603											
NEU2	4759	broad.mit.edu	37	chr2	233897493	233897493	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcagtccctgctggccttcGcggaacagcgggcaagcaag	14	13	0	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr2:233897493G>A	uc010zmn.1	+	1	112	c.112G>A	c.(112-114)GCG>ACG	p.A38T		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	38							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GCTGGCCTTCGCGGAACAGCG	0.622													A	233897493	A	A	233897493	3	1	42	1	0	0	0	0	1	0	0	0	10342	1087	38	1	114	1	NEU2	2	233897493	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	869169	233897493	9301880	15	2604											
DGKD	8527	broad.mit.edu	37	chr2	234358633	234358633	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actctccttgcacagctgtcGatgagcagaatgcccagacc	9	14	1	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr2:234358633G>A	uc002vui.1	+	16	1906	c.1894G>A	c.(1894-1896)GAT>AAT	p.D632N	DGKD_uc002vuj.1_Missense_Mutation_p.D588N|DGKD_uc010fyh.1_Missense_Mutation_p.D499N|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	632					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CACAGCTGTCGATGAGCAGAA	0.642													A	234358633	A	A	234358633	3	1	42	1	0	0	0	0	1	0	0	0	4467	1058	37	2	1980	2	DGKD	2	234358633	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	461140	234358633	8840740	16	2605											
TRIM71	131405	broad.mit.edu	37	chr3	32859692	32859692	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcctcgcagacgtccacGtcgtcggggggcggcggcgg	17	15	0	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr3:32859692G>A	uc003cff.2	+	1	183	c.120G>A	c.(118-120)ACG>ACA	p.T40T		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	40	RING-type.|Ser-rich.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						AGACGTCCACGTCGTcggggg	0.532													A	32859692	A	A	32859692	2	1	42	1	0	0	0	0	0	0	0	1	16541	1132	40	1		1	TRIM71	3	32859692	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08		32859692	165162738	17	2606											
SCAP	22937	broad.mit.edu	37	chr3	47460316	47460316	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagcgtgactgggatgacgGgcagcaggctgatgtacctg	18	8	0	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr3:47460316G>A	uc003crh.1	-	14	2213	c.1958C>T	c.(1957-1959)CCC>CTC	p.P653L	SCAP_uc011baz.1_Missense_Mutation_p.P398L|SCAP_uc003crg.2_Missense_Mutation_p.P261L	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	653	Lumenal (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		TGGGATGACGGGCAGCAGGCT	0.706													A	47460316	A	A	47460316	3	1	42	1	0	0	0	0	1	0	0	0	13877	1232	43	3	1921	3	SCAP	3	47460316	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	14600624	47460316	150562114	18	2607											
FAM116A	201627	broad.mit.edu	37	chr3	57627463	57627463	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagggttggttactcctaatAtaactgagggcctataaaaa	9	6	0	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr3:57627463A>G	uc003dja.2	-	12	1120	c.1049T>C	c.(1048-1050)ATA>ACA	p.I350T		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	350										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		TACTCCTAATATAACTGAGGG	0.313													G	57627463	G	G	57627463	3	3	42	1	0	0	0	0	1	0	0	0	5407	449	16	4	813	4	FAM116A	3	57627463	Missense_Mutation	SNP	A	TCGA-06-0195-01B-01D-1491-08	10167147	57627463	140394967	19	2608											
RUVBL1	8607	broad.mit.edu	37	chr3	127784027	127784027	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttgaaggcagcaggtttccaGatgagctggacaagcatgtt	13	7	0	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr3:127784027G>C	uc003eke.2	-	5	540	c.276C>G	c.(274-276)ATC>ATG	p.I92M	RUVBL1_uc003ekf.2_3'UTR|SEC61A1_uc003ekb.2_Intron|SEC61A1_uc003ekc.2_Intron|SEC61A1_uc003ekd.2_Intron|SEC61A1_uc003ekg.2_5'UTR	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		CAGGTTTCCAGATGAGCTGGA	0.448													C	127784027	C	C	127784027	3	2	42	1	0	0	0	0	1	0	0	0	13752	957	33	5		5	RUVBL1	3	127784027	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	70156564	127784027	70238403	20	2609											
TM4SF18	116441	broad.mit.edu	37	chr3	149051122	149051122	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attatactccaaagtgcaagCggaatcagcaaacaacttag	7	9	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr3:149051122C>A	uc003exa.2	-	2	185	c.48G>T	c.(46-48)CCG>CCT	p.P16P		NM_138786	NP_620141	Q96CE8	T4S18_HUMAN	transmembrane 4 L six family member 18	16	Helical; (Potential).					integral to membrane				ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			AAAGTGCAAGCGGAATCAGCA	0.443													A	149051122	A	A	149051122	2	1	42	1	0	0	0	0	0	0	0	1	15964	755	27	5		5	TM4SF18	3	149051122	Silent	SNP	C	TCGA-06-0195-01B-01D-1491-08	21267095	149051122	48971308	21	2610											
AADAC	13	broad.mit.edu	37	chr3	151532029	151532029	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atacgcctctcccagataacGttgaggagccatggagaatg	11	10	1	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr3:151532029G>A	uc003eze.2	+	1	169	c.79G>A	c.(79-81)GTT>ATT	p.V27I		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	27	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CCCAGATAACGTTGAGGAGCC	0.408													A	151532029	A	A	151532029	3	1	42	1	0	0	0	0	1	0	0	0	10	1145	40	1	81	1	AADAC	3	151532029	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	2480907	151532029	46490401	22	2611											
HTR3E	285242	broad.mit.edu	37	chr3	183822631	183822631	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atatgtaagtaatgaaggtcGcatcaggtataagaaaccca	9	6	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr3:183822631G>A	uc010hxq.2	+	5	912	c.446G>A	c.(445-447)CGC>CAC	p.R149H	HTR3E_uc003fml.3_Missense_Mutation_p.R134H|HTR3E_uc003fmm.2_Missense_Mutation_p.R164H|HTR3E_uc010hxr.2_Missense_Mutation_p.R175H|HTR3E_uc003fmn.2_Missense_Mutation_p.R149H	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	149	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AATGAAGGTCGCATCAGGTAT	0.488													A	183822631	A	A	183822631	3	1	42	1	0	0	0	0	1	0	0	0	7448	1087	38	1	505	1	HTR3E	3	183822631	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	32290602	183822631	14199799	23	2612											
ATP13A4	84239	broad.mit.edu	37	chr3	193158372	193158372	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tttctgaaattcttccaccaGactggacttctgcccaggag	8	12	3	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr3:193158372G>A	uc003ftd.2	-	21	2602	c.2494C>T	c.(2494-2496)CTG>TTG	p.L832L	ATP13A4_uc003fte.1_Silent_p.L832L|ATP13A4_uc011bsr.1_Silent_p.L303L|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	832	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TCTTCCACCAGACTGGACTTC	0.458													A	193158372	A	A	193158372	2	1	42	1	0	0	0	0	0	0	0	1	1126	933	33	3		3	ATP13A4	3	193158372	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08	9335741	193158372	4864058	24	2613											
ZFYVE28	57732	broad.mit.edu	37	chr4	2306576	2306576	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcatctcagccgtctctgcGtcatccgcacccacctccca	5	20	4	0	rs146596546	by1000genomes	TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr4:2306576G>A	uc003gex.1	-	8	1810	c.1491C>T	c.(1489-1491)GAC>GAT	p.D497D	ZFYVE28_uc011bvk.1_Silent_p.D427D|ZFYVE28_uc011bvl.1_Silent_p.D467D|ZFYVE28_uc003gew.1_Silent_p.D383D	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	497					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						CCGTCTCTGCGTCATCCGCAC	0.672													A	2306576	A	A	2306576	2	1	42	1	0	0	0	0	0	0	0	1	17667	1136	40	1		1	ZFYVE28	4	2306576	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08		2306576	188847700	25	2614											
SH3TC1	54436	broad.mit.edu	37	chr4	8230213	8230213	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacctcctggaggccgtgcGgctgttctcgaggctgcccc	13	16	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr4:8230213G>A	uc003gkv.3	+	12	2893	c.2792G>A	c.(2791-2793)CGG>CAG	p.R931Q	SH3TC1_uc003gkw.3_Missense_Mutation_p.R855Q|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	931							binding			large_intestine(2)|pancreas(1)	3						GAGGCCGTGCGGCTGTTCTCG	0.701													A	8230213	A	A	8230213	3	1	42	1	0	0	0	0	1	0	0	0	14261	1116	39	2	2834	2	SH3TC1	4	8230213	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	5923637	8230213	182924063	26	2615											
RBM47	54502	broad.mit.edu	37	chr4	40440789	40440789	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaccatgctgtagcccgtgCgctccatcagcgccagcagt	11	16	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr4:40440789C>T	uc003gvc.2	-	4	832	c.122G>A	c.(121-123)CGC>CAC	p.R41H	RBM47_uc003gvd.2_Missense_Mutation_p.R41H|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.R3H|RBM47_uc003gvg.1_Missense_Mutation_p.R41H	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	41						nucleus	nucleotide binding|RNA binding			breast(3)	3						GTAGCCCGTGCGCTCCATCAG	0.731													T	40440789	T	T	40440789	3	4	42	1	0	0	0	0	1	0	0	0	13141	768	27	1	1675	1	RBM47	4	40440789	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	32210576	40440789	150713487	27	2616											
CSN3	1448	broad.mit.edu	37	chr4	71115169	71115169	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttgcagttactccacctaCggcataaaaacaccaaggaa	7	11	0	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr4:71115169C>T	uc003hfe.3	+	4	600	c.542C>T	c.(541-543)ACG>ATG	p.T181M		NM_005212	NP_005203	P07498	CASK_HUMAN	casein kappa precursor	181				TPPT -> PTTS (in Ref. 5; AA sequence and 6; AA sequence).		extracellular region	protein binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						ACTCCACCTACGGCATAAAAA	0.413													T	71115169	T	T	71115169	3	4	42	1	0	0	0	0	1	0	0	0	3949	536	19	1	552	1	CSN3	4	71115169	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	30674380	71115169	120039107	28	2617											
MORF4	10934	broad.mit.edu	37	chr4	174537295	174537295	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gtggcactccatacacctggGacatgggtgcatcgggacaa	13	11	0	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr4:174537295G>T	uc011cke.1	-	1	500	c.500C>A	c.(499-501)TCC>TAC	p.S167Y		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		ATACACCTGGGACATGGGTGC	0.443													T	174537295	T	T	174537295	3	4	42	1	0	0	0	0	1	0	0	0	9705	1174	41	5	210	5	MORF4	4	174537295	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	103422126	174537295	16616981	29	2618											
ADAMTS16	170690	broad.mit.edu	37	chr5	5232628	5232628	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcgcctctgcaccaaccccAagtaagtatgccttgacctc	7	16	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr5:5232628A>G	uc003jdl.2	+	12	1987	c.1849A>G	c.(1849-1851)AAG>GAG	p.K617E	ADAMTS16_uc003jdk.1_Missense_Mutation_p.K617E|ADAMTS16_uc010itk.1_5'Flank	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	617	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CACCAACCCCAAGTAAGTATG	0.527													G	5232628	G	G	5232628	3	3	42	1	0	0	0	0	1	0	0	0	261	144	5	4	1895	4	ADAMTS16	5	5232628	Missense_Mutation	SNP	A	TCGA-06-0195-01B-01D-1491-08		5232628	175682632	30	2619											
TRPC7	57113	broad.mit.edu	37	chr5	135587388	135587388	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgagacattgtgcagcgtgtCgtcctgcacgtgctggtcca	13	12	0	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr5:135587388C>T	uc003lbn.1	-	5	1528	c.1525G>A	c.(1525-1527)GAC>AAC	p.D509N	TRPC7_uc010jef.1_Missense_Mutation_p.D446N|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.D440N|TRPC7_uc010jei.1_Missense_Mutation_p.D385N|TRPC7_uc010jej.1_Missense_Mutation_p.D61N	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	510	Extracellular (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGCAGCGTGTCGTCCTGCACG	0.602													T	135587388	T	T	135587388	3	4	42	1	0	0	0	0	1	0	0	0	16581	884	31	2	1088	2	TRPC7	5	135587388	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	130354760	135587388	45327872	31	2620											
KIAA0141	9812	broad.mit.edu	37	chr5	141316857	141316857	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cttgagatgttaccagcagtCagccgctctgggaaatgagg	13	9	2	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr5:141316857C>T	uc003lls.2	+	11	1366	c.1244C>T	c.(1243-1245)TCA>TTA	p.S415L	KIAA0141_uc003llt.2_Missense_Mutation_p.S415L|KIAA0141_uc003llu.1_RNA	NM_001142603	NP_001136075	Q14154	DELE_HUMAN	hypothetical protein LOC9812 precursor	415	TPR 6.				apoptosis|regulation of caspase activity	mitochondrion	protein binding			skin(1)	1		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACCAGCAGTCAGCCGCTCTG	0.562													T	141316857	T	T	141316857	3	4	42	1	0	0	0	0	1	0	0	0	8156	838	29	3	1286	3	KIAA0141	5	141316857	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	5729469	141316857	39598403	32	2621											
SOX30	11063	broad.mit.edu	37	chr5	157078323	157078323	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagggatcctaaggtcttgcTggtgcggcccaaaggcaccg	14	11	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr5:157078323T>G	uc003lxb.1	-	1	1106	c.764A>C	c.(763-765)CAG>CCG	p.Q255P	SOX30_uc003lxc.1_Missense_Mutation_p.Q255P|SOX30_uc011dds.1_Intron	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	255					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAGGTCTTGCTGGTGCGGCCC	0.642													G	157078323	G	G	157078323	3	3	42	1	0	0	0	0	1	0	0	0	14952	1580	55	5	1517	5	SOX30	5	157078323	Missense_Mutation	SNP	T	TCGA-06-0195-01B-01D-1491-08	15761466	157078323	23836937	33	2622											
DNAH8	1769	broad.mit.edu	37	chr6	38709656	38709656	+	Frame_Shift_Del	DEL	T	-	-													aaatgttgcacactccaaacTgctaaaggtaaaaggctttt							TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr6:38709656delT	uc003ooe.1	+	6	1235	c.635delT	c.(634-636)CTGfs	p.L212fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CACTCCAAACTGCTAAAGGTA	0.343													-	38709656	-	-	38709656	7	5	42	1	0	1	0	1	0	0	0	0	4607	1580	55	0	649	0	DNAH8	6	38709656	Frame_Shift_Del	DEL	T	TCGA-06-0195-01B-01D-1491-08		38709656	132405411	34	2623											
FILIP1	27145	broad.mit.edu	37	chr6	76023600	76023600	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtcttcatcaaatccccttCgaccacttccaattgttgga	5	13	3	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr6:76023600C>T	uc003pia.2	-	5	2321	c.1948G>A	c.(1948-1950)GAA>AAA	p.E650K	FILIP1_uc003phy.1_Missense_Mutation_p.E650K|FILIP1_uc003phz.2_Missense_Mutation_p.E551K|FILIP1_uc010kbe.2_Missense_Mutation_p.E653K|FILIP1_uc003pib.1_Missense_Mutation_p.E402K	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	650	Potential.									skin(3)|ovary(1)	4						AAATCCCCTTCGACCACTTCC	0.418													T	76023600	T	T	76023600	3	4	42	1	0	0	0	0	1	0	0	0	5894	893	31	2	1701	2	FILIP1	6	76023600	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	37313944	76023600	95091467	35	2624											
HTR1B	3351	broad.mit.edu	37	chr6	78172165	78172165	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacaataaaggctcccaaaAtgatccctagggtcttggtg	9	10	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr6:78172165A>C	uc003pil.1	-	1	956	c.956T>G	c.(955-957)ATT>AGT	p.I319S		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	319	Helical; Name=6; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	GGCTCCCAAAATGATCCCTAG	0.507													C	78172165	C	C	78172165	3	2	42	1	0	0	0	0	1	0	0	0	7437	101	4	5	220	5	HTR1B	6	78172165	Missense_Mutation	SNP	A	TCGA-06-0195-01B-01D-1491-08	2148565	78172165	92942902	36	2625											
HDAC2	3066	broad.mit.edu	37	chr6	114266601	114266601	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tatgcagtttgaagtctggtCcaaaatactcaaagtaatca	7	7	3	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr6:114266601C>T	uc003pwd.1	-	10	1298	c.1298G>A	c.(1297-1299)GGA>GAA	p.G433E	HDAC2_uc003pwc.1_Missense_Mutation_p.G309E|HDAC2_uc003pwe.1_Missense_Mutation_p.G309E	NM_001527	NP_001518	Q92769	HDAC2_HUMAN	histone deacetylase 2	339					blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			skin(2)|ovary(1)|central_nervous_system(1)	4		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	GAAGTCTGGTCCAAAATACTC	0.299													T	114266601	T	T	114266601	3	4	42	1	0	0	0	0	1	0	0	0	7007	855	30	3	470	3	HDAC2	6	114266601	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	36094436	114266601	56848466	37	2626											
SYNE1	23345	broad.mit.edu	37	chr6	152644693	152644693	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gttggggcggctccatcctgGagcatgctcagggtttgctg	16	10	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr6:152644693G>A	uc010kiw.2	-	82	16439	c.15837C>T	c.(15835-15837)CTC>CTT	p.L5279L	SYNE1_uc003qot.3_Silent_p.L5208L|SYNE1_uc003qou.3_Silent_p.L5279L|SYNE1_uc010kiz.2_Silent_p.L1034L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5279	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCCATCCTGGAGCATGCTCA	0.567										HNSCC(10;0.0054)			A	152644693	A	A	152644693	2	1	42	1	0	0	0	0	0	0	0	1	15442	1161	41	3		3	SYNE1	6	152644693	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08	38378092	152644693	18470374	38	2627											
TIAM2	26230	broad.mit.edu	37	chr6	155571053	155571053	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagatctatgaggattatGggaccgtgtttgaccagcta	12	6	1	4			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr6:155571053G>A	uc003qqb.2	+	23	5174	c.3901G>A	c.(3901-3903)GGG>AGG	p.G1301R	TIAM2_uc003qqe.2_Missense_Mutation_p.G1301R|TIAM2_uc010kjj.2_Missense_Mutation_p.G834R|TIAM2_uc003qqf.2_Missense_Mutation_p.G677R|TIAM2_uc011efl.1_Missense_Mutation_p.G637R|TIAM2_uc003qqg.2_Missense_Mutation_p.G613R|TIAM2_uc003qqh.2_Missense_Mutation_p.G226R	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1301					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGAGGATTATGGGACCGTGTT	0.473													A	155571053	A	A	155571053	3	1	42	1	0	0	0	0	1	0	0	0	15888	1348	47	3	3971	3	TIAM2	6	155571053	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	2926360	155571053	15544014	39	2628											
AMZ1	155185	broad.mit.edu	37	chr7	2740173	2740174	+	Frame_Shift_Ins	INS	-	A	A													cactgacgcagccctgcagcINSagctgtatgtgtccgccttc							TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr7:2740173_2740174insA	uc003smr.1	+	2	449_450	c.88_89insA	c.(88-90)CAGfs	p.Q30fs	AMZ1_uc003sms.1_Frame_Shift_Ins_p.Q30fs|AMZ1_uc011jwa.1_5'Flank	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	30							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		AGCCCTGCAGCAGCTGTATGTG	0.668													A	2740174	A	A	2740173	7	5	42	1	0	1	1	0	0	0	0	0	596	711	25	0	90	0	AMZ1	7	2740173	Frame_Shift_Ins	INS	-	TCGA-06-0195-01B-01D-1491-08		2740173	156398490	40	2629											
ABCB4	5244	broad.mit.edu	37	chr7	87060779	87060779	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcagttcgctgtggcttcCttgctccacaattactccat	6	14	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr7:87060779C>T	uc003uiv.1	-	15	1910	c.1834G>A	c.(1834-1836)GGA>AGA	p.G612R	ABCB4_uc003uiw.1_Missense_Mutation_p.G612R|ABCB4_uc003uix.1_Missense_Mutation_p.G612R	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	612	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CTGTGGCTTCCTTGCTCCACA	0.478													T	87060779	T	T	87060779	3	4	42	1	0	0	0	0	1	0	0	0	43	690	24	3	2082	3	ABCB4	7	87060779	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	84320606	87060779	72077884	41	2630											
DBF4	10926	broad.mit.edu	37	chr7	87525787	87525787	+	Splice_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttcactatatatttttttttAgggcaaaagagttggtagtg	9	3	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr7:87525787A>T	uc003ujf.1	+	7	1102	c.598_splice	c.e7-2	p.G200_splice	DBF4_uc003ujh.1_Splice_Site|DBF4_uc003ujg.1_Splice_Site|DBF4_uc011khf.1_Splice_Site_p.G2_splice	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase						cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				ATTTTTTTTTAGGGCAAAAGA	0.299													T	87525787	T	T	87525787	5	4	42	1	0	0	0	0	0	0	1	0	4248	434	15	5	622	5	DBF4	7	87525787	Splice_Site	SNP	A	TCGA-06-0195-01B-01D-1491-08	465008	87525787	71612876	42	2631											
NPTX2	4885	broad.mit.edu	37	chr7	98256538	98256538	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacatctgtgtcacctggaCgacacgggatggcatgtggg	14	11	2	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr7:98256538C>T	uc003upl.2	+	4	1127	c.950C>T	c.(949-951)ACG>ATG	p.T317M		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	317	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GTCACCTGGACGACACGGGAT	0.642													T	98256538	T	T	98256538	3	4	42	1	0	0	0	0	1	0	0	0	10603	536	19	1	964	1	NPTX2	7	98256538	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	10730751	98256538	60882125	43	2632											
FBXO24	26261	broad.mit.edu	37	chr7	100187923	100187923	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgtcgcagactcagtccgCgcctccaagatcagggttct	10	14	4	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr7:100187923C>T	uc003uvm.1	+	3	558	c.265C>T	c.(265-267)CGC>TGC	p.R89C	FBXO24_uc010lha.1_RNA|FBXO24_uc003uvl.1_Missense_Mutation_p.R89C|FBXO24_uc003uvn.1_Intron|uc011kjy.1_RNA|FBXO24_uc011kjz.1_Missense_Mutation_p.R127C|FBXO24_uc011kka.1_Missense_Mutation_p.R77C	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	89						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					ACTCAGTCCGCGCCTCCAAGA	0.602													T	100187923	T	T	100187923	3	4	42	1	0	0	0	0	1	0	0	0	5735	768	27	1	432	1	FBXO24	7	100187923	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	1931385	100187923	58950740	44	2633											
DLD	1738	broad.mit.edu	37	chr7	107545876	107545876	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctacgaaagctgatggcgGcactcaggttattgatacaa	11	8	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr7:107545876G>A	uc003vet.2	+	7	619	c.509G>A	c.(508-510)GGC>GAC	p.G170D	DLD_uc010ljm.1_RNA|DLD_uc011kmg.1_Intron|DLD_uc011kmh.1_Missense_Mutation_p.G147D|DLD_uc011kmi.1_Missense_Mutation_p.G71D	NM_000108	NP_000099	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase precursor	170					branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			central_nervous_system(1)	1					NADH(DB00157)	GCTGATGGCGGCACTCAGGTT	0.358													A	107545876	A	A	107545876	3	1	42	1	0	0	0	0	1	0	0	0	4551	1203	42	3	535	3	DLD	7	107545876	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	7357953	107545876	51592787	45	2634											
SSPO	23145	broad.mit.edu	37	chr7	149508065	149508065	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaggggcacctctaccccccGggcagcactgtggttcgtcc	13	16	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr7:149508065G>C	uc010lpk.2	+	67	9459	c.9459G>C	c.(9457-9459)CCG>CCC	p.P3153P		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3153					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCTACCCCCCGGGCAGCACTG	0.602													C	149508065	C	C	149508065	2	2	42	1	0	0	0	0	0	0	0	1	15188	1103	39	5		5	SSPO	7	149508065	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08	41962189	149508065	9630598	46	2635											
PKHD1L1	93035	broad.mit.edu	37	chr8	110476765	110476765	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttttgggtcaccaacccgaaCaataccatacgacacaatgc	6	13	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr8:110476765C>A	uc003yne.2	+	49	7808	c.7704C>A	c.(7702-7704)AAC>AAA	p.N2568K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2568	Extracellular (Potential).|PbH1 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCAACCCGAACAATACCATAC	0.468										HNSCC(38;0.096)			A	110476765	A	A	110476765	3	1	42	1	0	0	0	0	1	0	0	0	11972	477	17	5	7898	5	PKHD1L1	8	110476765	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08		110476765	35887257	47	2636											
INSL6	11172	broad.mit.edu	37	chr9	5185586	5185586	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagccacagcagggacaagCggaggagccgcggcatccct	14	14	0	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr9:5185586C>T	uc003zix.2	-	1	33	c.17G>A	c.(16-18)CGC>CAC	p.R6H		NM_007179	NP_009110	Q9Y581	INSL6_HUMAN	insulin-like 6 precursor	6						extracellular region	hormone activity				0	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		CAGGGACAAGCGGAGGAGCCG	0.642													T	5185586	T	T	5185586	3	4	42	1	0	0	0	0	1	0	0	0	7770	768	27	1	632	1	INSL6	9	5185586	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08		5185586	136027845	48	2637											
PLIN2	123	broad.mit.edu	37	chr9	19116616	19116616	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagctgctgagtcaggttgCgggcaattgcaagagtacgt	16	7	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr9:19116616C>T	uc003zno.2	-	8	1123	c.944G>A	c.(943-945)CGC>CAC	p.R315H	PLIN2_uc011lna.1_Missense_Mutation_p.R287H	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	315					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						AGTCAGGTTGCGGGCAATTGC	0.463													T	19116616	T	T	19116616	3	4	42	1	0	0	0	0	1	0	0	0	12090	768	27	1	373	1	PLIN2	9	19116616	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	13931030	19116616	122096815	49	2638											
FAM75C1	441452	broad.mit.edu	37	chr9	90537694	90537694	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaaagcccaatgtttcccCctactcacaagagggagaac	8	14	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr9:90537694C>T	uc010mqi.2	+	4	2901	c.2872C>T	c.(2872-2874)CCT>TCT	p.P958S	FAM75C1_uc004apq.3_Missense_Mutation_p.P941S	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						AATGTTTCCCCCTACTCACAA	0.483													T	90537694	T	T	90537694	3	4	42	1	0	0	0	0	1	0	0	0	5623	623	22	3	2886	3	FAM75C1	9	90537694	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	71421078	90537694	50675737	50	2639											
FBP1	2203	broad.mit.edu	37	chr9	97380089	97380089	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggttccaacggacacaagGcaatcgatgttggaagatcc	11	9	0	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr9:97380089G>A	uc004auw.3	-	3	718	c.387C>T	c.(385-387)TGC>TGT	p.C129C	FBP1_uc010mrl.2_Silent_p.C129C	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	129					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	CGGACACAAGGCAATCGATGT	0.388													A	97380089	A	A	97380089	2	1	42	1	0	0	0	0	0	0	0	1	5705	1195	42	3		3	FBP1	9	97380089	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08	6842395	97380089	43833342	51	2640											
GDF2	2658	broad.mit.edu	37	chr10	48413762	48413762	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgatagcgtgtttcgtcggcGtcacatcgtcagccaagggg	14	11	2	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr10:48413762G>A	uc001jfa.1	-	2	1269	c.1106C>T	c.(1105-1107)ACG>ATG	p.T369M		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	369					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						TTTCGTCGGCGTCACATCGTC	0.582													A	48413762	A	A	48413762	3	1	42	1	0	0	0	0	1	0	0	0	6314	1145	40	1	187	1	GDF2	10	48413762	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08		48413762	87120985	52	2641											
PTEN	5728	broad.mit.edu	37	chr10	89692992	89692992	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatttctatggggaagtaaGgaccagagacaaaaaggtaa	12	4	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr10:89692992G>A	uc001kfb.2	+	6	1507	c.476G>A	c.(475-477)AGG>AAG	p.R159K		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	159	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R159S(4)|p.R55fs*1(4)|p.R159K(4)|p.?(2)|p.Y27fs*1(2)|p.R159fs*8(2)|p.Y27_N212>Y(2)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGGGAAGTAAGGACCAGAGAC	0.363		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89692992	A	A	89692992	3	1	42	1	0	0	0	0	1	0	0	0	12738	1000	35	3	494	3	PTEN	10	89692992	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	41279230	89692992	45841755	53	2642											
PRDM11	56981	broad.mit.edu	37	chr11	45117447	45117447	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctctcttcctttaccagagaGagaaagtaagttgtttaagc	8	8	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr11:45117447G>A	uc001myo.2	+	2	340	c.91G>A	c.(91-93)GAG>AAG	p.E31K		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	31										upper_aerodigestive_tract(1)	1						ttaccagagagagaaagtaag	0.035													A	45117447	A	A	45117447	3	1	42	1	0	0	0	0	1	0	0	0	12452	943	33	3	93	3	PRDM11	11	45117447	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08		45117447	89889069	54	2643											
BCL9L	283149	broad.mit.edu	37	chr11	118773532	118773532	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccgggggtggcggcggcGgcagtggaggtggctgggac	26	8	0	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr11:118773532G>A	uc001pug.2	-	6	1885	c.920C>T	c.(919-921)CCG>CTG	p.P307L	BCL9L_uc009zal.2_Missense_Mutation_p.P302L	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	307	Pro-rich.|Necessary for interaction with CTNNB1 (By similarity).				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TGGCGGCGGCGGCAGTGGAGG	0.716													A	118773532	A	A	118773532	3	1	42	1	0	0	0	0	1	0	0	0	1382	1116	39	2	3591	2	BCL9L	11	118773532	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	73656085	118773532	16232984	55	2644											
TRIM29	23650	broad.mit.edu	37	chr11	120008709	120008709	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggcttctgggctcgaccCgttgctcctggaggcatctg	13	14	2	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr11:120008709C>T	uc001pwz.2	-	1	155	c.31G>A	c.(31-33)GGG>AGG	p.G11R	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	11					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GGGCTCGACCCGTTGCTCCTG	0.632													T	120008709	T	T	120008709	3	4	42	1	0	0	0	0	1	0	0	0	16500	652	23	2	1771	2	TRIM29	11	120008709	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	1235177	120008709	14997807	56	2645											
LRTM2	654429	broad.mit.edu	37	chr12	1943505	1943505	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggacatgcggatggtccccaTggagatgttcaactactgct	12	10	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:1943505T>G	uc001qjt.2	+	5	1537	c.731T>G	c.(730-732)ATG>AGG	p.M244R	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Missense_Mutation_p.M244R|LRTM2_uc010sdx.1_Missense_Mutation_p.M244R|LRTM2_uc001qjv.2_Missense_Mutation_p.M6R	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	244	LRRCT.|Extracellular (Potential).					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			ATGGTCCCCATGGAGATGTTC	0.597													G	1943505	G	G	1943505	3	3	42	1	0	0	0	0	1	0	0	0	9045	1464	51	5	741	5	LRTM2	12	1943505	Missense_Mutation	SNP	T	TCGA-06-0195-01B-01D-1491-08		1943505	131908390	57	2646											
CD163L1	283316	broad.mit.edu	37	chr12	7527093	7527093	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtcgtgctgcccccagccGcgggaagggcactgccacaa	13	16	0	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:7527093G>A	uc001qsy.2	-	13	3380	c.3354C>T	c.(3352-3354)CGC>CGT	p.R1118R	CD163L1_uc010sge.1_Silent_p.R1128R	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1118	SRCR 10.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GCCCCCAGCCGCGGGAAGGGC	0.617													A	7527093	A	A	7527093	2	1	42	1	0	0	0	0	0	0	0	1	2968	1074	38	1		1	CD163L1	12	7527093	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08	5583588	7527093	126324802	58	2647											
OVCH1	341350	broad.mit.edu	37	chr12	29628035	29628035	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccttgaagccttgtaaaCgatttttaccatcactttta	6	9	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:29628035C>T	uc001rix.1	-	14	1559	c.1559G>A	c.(1558-1560)CGT>CAT	p.R520H		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	520	CUB 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity	p.R520H(1)		ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GCCTTGTAAACGATTTTTACC	0.338													T	29628035	T	T	29628035	3	4	42	1	0	0	0	0	1	0	0	0	11323	536	19	1	1905	1	OVCH1	12	29628035	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	22100942	29628035	104223860	59	2648											
KRT79	338785	broad.mit.edu	37	chr12	53217720	53217720	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcctctggatagtgcggGtgagctcagcaatctcgttc	13	11	3	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:53217720G>A	uc001sbb.2	-	6	1130	c.1097C>T	c.(1096-1098)ACC>ATC	p.T366I	KRT79_uc001sba.2_Missense_Mutation_p.T137I	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	366	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						GATAGTGCGGGTGAGCTCAGC	0.612													A	53217720	A	A	53217720	3	1	42	1	0	0	0	0	1	0	0	0	8492	1261	44	3	526	3	KRT79	12	53217720	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	23589685	53217720	80634175	60	2649											
EIF4B	1975	broad.mit.edu	37	chr12	53421578	53421578	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctctagagtatcgagatcGttatgattcagaccggtatc	9	9	2	4			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:53421578G>A	uc001sbh.3	+	7	886	c.680G>A	c.(679-681)CGT>CAT	p.R227H	EIF4B_uc009zmp.1_RNA|EIF4B_uc010snu.1_Missense_Mutation_p.R227H|EIF4B_uc010snv.1_Missense_Mutation_p.R188H|EIF4B_uc001sbi.2_5'UTR	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	227	Arg-rich.|Asp-rich.				insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						TATCGAGATCGTTATGATTCA	0.373													A	53421578	A	A	53421578	3	1	42	1	0	0	0	0	1	0	0	0	5027	1145	40	1	706	1	EIF4B	12	53421578	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	203858	53421578	80430317	61	2650											
CPSF6	11052	broad.mit.edu	37	chr12	69646899	69646899	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatgatattttggagataaaAttttttgaaaatcgggcaaa	8	2	0	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:69646899A>C	uc001sut.3	+	3	449	c.339A>C	c.(337-339)AAA>AAC	p.K113N	CPSF6_uc001suu.3_Missense_Mutation_p.K113N	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	113	RRM.|Necessary for interaction with NUDT21/CPSF5.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			TGGAGATAAAATTTTTTGAAA	0.323													C	69646899	C	C	69646899	3	2	42	1	0	0	0	0	1	0	0	0	3829	98	4	5	349	5	CPSF6	12	69646899	Missense_Mutation	SNP	A	TCGA-06-0195-01B-01D-1491-08	16225321	69646899	64204996	62	2651											
HAL	3034	broad.mit.edu	37	chr12	96389631	96389631	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcccacagtgagctgcgCgtcctggcagggcactgcca	13	16	0	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:96389631C>T	uc001tem.1	-	2	355	c.58G>A	c.(58-60)GCG>ACG	p.A20T	HAL_uc009zti.1_RNA|HAL_uc010suw.1_5'UTR|HAL_uc010sux.1_Missense_Mutation_p.A20T	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	20					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	GTGAGCTGCGCGTCCTGGCAG	0.642													T	96389631	T	T	96389631	3	4	42	1	0	0	0	0	1	0	0	0	6947	768	27	1	1995	1	HAL	12	96389631	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	26742732	96389631	37462264	63	2652											
STAB2	55576	broad.mit.edu	37	chr12	104126949	104126949	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttgaagtttcatgtgataCgagatgccaaggtatttagt	10	4	1	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:104126949C>T	uc001tjw.2	+	51	5635	c.5449C>T	c.(5449-5451)CGA>TGA	p.R1817*	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1817	Extracellular (Potential).|FAS1 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TCATGTGATACGAGATGCCAA	0.463													T	104126949	T	T	104126949	4	4	42	1	0	0	0	0	0	1	0	0	15237	528	19	1	5651	1	STAB2	12	104126949	Nonsense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	7737318	104126949	29724946	64	2653											
NFYB	4801	broad.mit.edu	37	chr12	104517017	104517017	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatttacctctctgaatttcTgaaggtataatttcagaggt	7	6	3	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:104517017T>C	uc001tkl.1	-	5	617	c.416A>G	c.(415-417)CAG>CGG	p.Q139R	NFYB_uc001tkk.1_Missense_Mutation_p.Q137R	NM_006166	NP_006157	P25208	NFYB_HUMAN	nuclear transcription factor Y, beta	139	B domain.					CCAAT-binding factor complex	repressing transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						TCTGAATTTCTGAAGGTATAA	0.244													C	104517017	C	C	104517017	3	2	42	1	0	0	0	0	1	0	0	0	10390	1580	55	4	223	4	NFYB	12	104517017	Missense_Mutation	SNP	T	TCGA-06-0195-01B-01D-1491-08	390068	104517017	29334878	65	2654											
TPCN1	53373	broad.mit.edu	37	chr12	113724880	113724880	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctatttcatcgtggtcctgCgccccctccagctgctgagg	10	15	2	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:113724880C>T	uc001tuw.2	+	19	1912	c.1615C>T	c.(1615-1617)CGC>TGC	p.R539C	TPCN1_uc001tux.2_Missense_Mutation_p.R611C|TPCN1_uc010syt.1_Missense_Mutation_p.R471C	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	539	Helical; Name=S4 of repeat II; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						CGTGGTCCTGCGCCCCCTCCA	0.617													T	113724880	T	T	113724880	3	4	42	1	0	0	0	0	1	0	0	0	16392	768	27	1	1905	1	TPCN1	12	113724880	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	9207863	113724880	20127015	66	2655											
SDSL	113675	broad.mit.edu	37	chr12	113873227	113873227	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgggggtgggggtctcctGgccggggtggtggctggcct	23	8	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:113873227G>A	uc001tvi.2	+	7	747	c.537G>A	c.(535-537)CTG>CTA	p.L179L	SDSL_uc009zwh.2_Silent_p.L179L	NM_138432	NP_612441	Q96GA7	SDSL_HUMAN	serine dehydratase-like	179					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	GGGGTCTCCTGGCCGGGGTGG	0.657													A	113873227	A	A	113873227	2	1	42	1	0	0	0	0	0	0	0	1	13976	1335	47	3		3	SDSL	12	113873227	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08	148347	113873227	19978668	67	2656											
SCARB1	949	broad.mit.edu	37	chr12	125292425	125292425	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagccacgaagcgataggtGgggatgccttcaaacacccc	13	12	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr12:125292425G>A	uc001ugo.3	-	7	1144	c.891C>T	c.(889-891)CCC>CCT	p.P297P	SCARB1_uc001ugn.3_Silent_p.P297P|SCARB1_uc001ugm.3_Silent_p.P297P|SCARB1_uc010tbd.1_Silent_p.P297P|SCARB1_uc010tbe.1_Silent_p.P256P|SCARB1_uc001ugp.3_Silent_p.P297P	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	297	Extracellular (Potential).		P -> S (mutation carriers have increased HDL cholesterol levels and a reduction in cholesterol efflux from macrophages).		adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	AGCGATAGGTGGGGATGCCTT	0.582													A	125292425	A	A	125292425	2	1	42	1	0	0	0	0	0	0	0	1	13881	1335	47	3		3	SCARB1	12	125292425	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08	11419198	125292425	8559470	68	2657											
RB1	5925	broad.mit.edu	37	chr13	48947596	48947596	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttttaaattcagcaagtgatCaaccttcagaaaatctgatt	5	7	4	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr13:48947596C>T	uc001vcb.2	+	12	1349	c.1183C>T	c.(1183-1185)CAA>TAA	p.Q395*	RB1_uc010act.1_Nonsense_Mutation_p.Q96*	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	395	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.Q395*(2)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGCAAGTGATCAACCTTCAGA	0.294		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	48947596	T	T	48947596	4	4	42	1	0	0	0	0	0	1	0	0	13098	827	29	3	1229	3	RB1	13	48947596	Nonsense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08		48947596	66222282	69	2658											
OR4K5	79317	broad.mit.edu	37	chr14	20389151	20389151	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtatgtagccatatgcaaacCcttatactatgtggtcatca	7	9	2	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr14:20389151C>A	uc010tkw.1	+	1	386	c.386C>A	c.(385-387)CCC>CAC	p.P129H		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATATGCAAACCCTTATACTAT	0.448													A	20389151	A	A	20389151	3	1	42	1	0	0	0	0	1	0	0	0	11073	623	22	5	388	5	OR4K5	14	20389151	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08		20389151	86960389	70	2659											
RNF151	146310	broad.mit.edu	37	chr16	2018613	2018614	+	Frame_Shift_Ins	INS	-	C	C													caagggtcccagcagcgctgINSccccctgggctgcggggcca							TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr16:2018613_2018614insC	uc002cnt.1	+	4	433_434	c.425_426insC	c.(424-426)TGCfs	p.C142fs		NM_174903	NP_777563	Q2KHN1	RN151_HUMAN	ring finger protein 151	142	TRAF-type.				cell differentiation|spermatogenesis	cytoplasm|nucleus	ubiquitin-protein ligase activity|zinc ion binding				0						CAGCAGCGCTGCCCCCTGGGCT	0.728													C	2018614	C	C	2018613	7	5	42	1	0	1	1	0	0	0	0	0	13452	1319	46	0	439	0	RNF151	16	2018613	Frame_Shift_Ins	INS	-	TCGA-06-0195-01B-01D-1491-08		2018613	88336140	71	2660											
ITGAX	3687	broad.mit.edu	37	chr16	31392315	31392315	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgctggcactcatcacagCggtactgtacaaagtgagtg	12	10	2	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr16:31392315C>T	uc002ebu.1	+	29	3441	c.3374C>T	c.(3373-3375)GCG>GTG	p.A1125V	ITGAX_uc002ebt.2_Missense_Mutation_p.A1125V	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	1125	Helical; (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTCATCACAGCGGTACTGTAC	0.542													T	31392315	T	T	31392315	3	4	42	1	0	0	0	0	1	0	0	0	7889	768	27	1	3488	1	ITGAX	16	31392315	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	29373702	31392315	58962438	72	2661											
SLC16A13	201232	broad.mit.edu	37	chr17	6941650	6941650	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagggggtccctgctgctgGtgtctgccctctccctccac	13	16	2	0	rs139041380		TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr17:6941650G>A	uc002geh.2	+	3	831	c.523G>A	c.(523-525)GTG>ATG	p.V175M		NM_201566	NP_963860	Q7RTY0	MOT13_HUMAN	monocarboxylate transporter 13	175	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(1)|skin(1)	2						CCTGCTGCTGGTGTCTGCCCT	0.667													A	6941650	A	A	6941650	3	1	42	1	0	0	0	0	1	0	0	0	14406	1261	44	3	533	3	SLC16A13	17	6941650	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08		6941650	74253560	73	2662											
DVL2	1856	broad.mit.edu	37	chr17	7130543	7130543	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcgggcctcccgccgctcaGgaaagccctccacgtgatgg	13	16	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr17:7130543G>A	uc002gez.1	-	13	1691	c.1409C>T	c.(1408-1410)CCT>CTT	p.P470L	DVL2_uc010vtr.1_Missense_Mutation_p.P464L	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	470	DEP.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						CCGCCGCTCAGGAAAGCCCTC	0.577													A	7130543	A	A	7130543	3	1	42	1	0	0	0	0	1	0	0	0	4836	1000	35	3	813	3	DVL2	17	7130543	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	188893	7130543	74064667	74	2663											
TP53	7157	broad.mit.edu	37	chr17	7577096	7577096	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctcttcctctgtgcgccggTctctcccaggacaggcacaa	9	16	3	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr17:7577096T>G	uc002gim.2	-	8	1036	c.842A>C	c.(841-843)GAC>GCC	p.D281A	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.D281A|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.D149A|TP53_uc010cng.1_Missense_Mutation_p.D149A|TP53_uc002gii.1_Missense_Mutation_p.D149A|TP53_uc010cnh.1_Missense_Mutation_p.D281A|TP53_uc010cni.1_Missense_Mutation_p.D281A|TP53_uc002gij.2_Missense_Mutation_p.D281A	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	281	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		D -> Y (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> V (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|D -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|D -> G (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|D -> A (in sporadic cancers; somatic mutation).|D -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.D281E(25)|p.D281H(19)|p.D281N(18)|p.D281G(10)|p.0?(7)|p.D281Y(6)|p.D281D(5)|p.D281V(3)|p.D281fs*63(2)|p.?(2)|p.R280_D281delRD(2)|p.D281A(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.D281R(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTGCGCCGGTCTCTCCCAGG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			G	7577096	G	G	7577096	3	3	42	1	0	0	0	0	1	0	0	0	16378	1667	58	5	444	5	TP53	17	7577096	Missense_Mutation	SNP	T	TCGA-06-0195-01B-01D-1491-08	446553	7577096	73618114	75	2664											
TP53	7157	broad.mit.edu	37	chr17	7577142	7577142	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctcaaagctgttccgtcCcagtagattaccactactca	5	15	2	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr17:7577142C>T	uc002gim.2	-	8	990	c.796G>A	c.(796-798)GGA>AGA	p.G266R	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G266R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G134R|TP53_uc010cng.1_Missense_Mutation_p.G134R|TP53_uc002gii.1_Missense_Mutation_p.G134R|TP53_uc010cnh.1_Missense_Mutation_p.G266R|TP53_uc010cni.1_Missense_Mutation_p.G266R|TP53_uc002gij.2_Missense_Mutation_p.G266R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	266	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(45)|p.G266R(42)|p.G266V(31)|p.G266*(12)|p.0?(7)|p.G266fs*79(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266G(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.G266fs*9(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTGTTCCGTCCCAGTAGATTA	0.517		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577142	T	T	7577142	3	4	42	1	0	0	0	0	1	0	0	0	16378	632	22	3	490	3	TP53	17	7577142	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	46	7577142	73618068	76	2665											
CCDC42	146849	broad.mit.edu	37	chr17	8638499	8638499	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgatctggaagaggttcagcGtggccatcttaatggtgcca	13	9	3	1	rs141089641	byFrequency	TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr17:8638499G>A	uc002gln.2	-	6	1015	c.788C>T	c.(787-789)ACG>ATG	p.T263M	CCDC42_uc002glo.2_Missense_Mutation_p.T189M	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	263										ovary(1)	1						GAGGTTCAGCGTGGCCATCTT	0.587													A	8638499	A	A	8638499	3	1	42	1	0	0	0	0	1	0	0	0	2814	1145	40	1	170	1	CCDC42	17	8638499	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	1061357	8638499	72556711	77	2666											
SLFN5	162394	broad.mit.edu	37	chr17	33591324	33591324	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctctcaaggaatattgattTtttctcaaagctgggctgtg	9	7	3	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr17:33591324T>C	uc002hjf.3	+	4	1378	c.1261T>C	c.(1261-1263)TTT>CTT	p.F421L	SLFN5_uc010wcg.1_Intron	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	421					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		AATATTGATTTTTTCTCAAAG	0.418													C	33591324	C	C	33591324	3	2	42	1	0	0	0	0	1	0	0	0	14737	1841	64	4	1271	4	SLFN5	17	33591324	Missense_Mutation	SNP	T	TCGA-06-0195-01B-01D-1491-08	24952825	33591324	47603886	78	2667											
FAM117A	81558	broad.mit.edu	37	chr17	47788746	47788746	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtggtggcctggggctggcCgggggaaggggagatcccgg	24	8	0	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr17:47788746C>T	uc002ipk.2	-	8	1302	c.1233G>A	c.(1231-1233)CCG>CCA	p.P411P	FAM117A_uc010wlz.1_Silent_p.P139P	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	411	Pro-rich.									ovary(1)	1						TGGGGCTGGCCGGGGGAAGGG	0.652													T	47788746	T	T	47788746	2	4	42	1	0	0	0	0	0	0	0	1	5409	639	23	2		2	FAM117A	17	47788746	Silent	SNP	C	TCGA-06-0195-01B-01D-1491-08	14197422	47788746	33406464	79	2668											
KCTD2	23510	broad.mit.edu	37	chr17	73049201	73049201	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgagaacagaacttcacaaGtaatgtatttggaactgtta	8	5	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr17:73049201G>A	uc002jmp.2	+	3	607	c.540_splice	c.e3+1	p.Q180_splice	KCTD2_uc010dfz.2_Splice_Site|KCTD2_uc002jmq.2_Splice_Site	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain							voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					AACTTCACAAGTAATGTATTT	0.478													A	73049201	A	A	73049201	5	1	42	1	0	0	0	0	0	0	1	0	8107	1043	36	3	551	3	KCTD2	17	73049201	Splice_Site	SNP	G	TCGA-06-0195-01B-01D-1491-08	25260455	73049201	8146009	80	2669											
NFIX	4784	broad.mit.edu	37	chr19	13184252	13184252	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagggcacttaagtttccaGgactgttttgtgacttccgg	11	9	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr19:13184252G>A	uc010xmx.1	+	4	716	c.663G>A	c.(661-663)CAG>CAA	p.Q221Q	NFIX_uc002mwd.2_Silent_p.Q213Q|NFIX_uc002mwe.2_Silent_p.Q205Q|NFIX_uc002mwf.2_Silent_p.Q216Q|NFIX_uc002mwg.1_Silent_p.Q212Q			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	213					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			TAAGTTTCCAGGACTGTTTTG	0.522													A	13184252	A	A	13184252	2	1	42	1	0	0	0	0	0	0	0	1	10374	991	35	3		3	NFIX	19	13184252	Silent	SNP	G	TCGA-06-0195-01B-01D-1491-08		13184252	45944731	81	2670											
CYP4F3	4051	broad.mit.edu	37	chr19	15758051	15758051	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgaaaagtggagccgccacCgtcggatgctgacgcctgcc	14	13	0	2	rs149124841	byFrequency	TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr19:15758051C>T	uc002nbj.2	+	5	492	c.442C>T	c.(442-444)CGT>TGT	p.R148C	CYP4F3_uc010xok.1_Missense_Mutation_p.R148C|CYP4F3_uc010xol.1_Missense_Mutation_p.R148C|CYP4F3_uc010xom.1_5'UTR|CYP4F3_uc002nbk.2_Missense_Mutation_p.R148C|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	148					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						GAGCCGCCACCGTCGGATGCT	0.567													T	15758051	T	T	15758051	3	4	42	1	0	0	0	0	1	0	0	0	4190	652	23	2	456	2	CYP4F3	19	15758051	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	2573799	15758051	43370932	82	2671											
MYO9B	4650	broad.mit.edu	37	chr19	17309077	17309077	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggcgacgcatcctccctcCcagacgcagggctgtccccg	11	19	0	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr19:17309077C>T	uc010eak.2	+	24	4350	c.4198C>T	c.(4198-4200)CCA>TCA	p.P1400S	MYO9B_uc002nfi.2_Missense_Mutation_p.P1400S|MYO9B_uc002nfj.1_Missense_Mutation_p.P1400S|MYO9B_uc002nfl.1_5'UTR	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1400	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						ATCCTCCCTCCCAGACGCAGG	0.622													T	17309077	T	T	17309077	3	4	42	1	0	0	0	0	1	0	0	0	10085	623	22	3	4288	3	MYO9B	19	17309077	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	1551026	17309077	41819906	83	2672											
ZNF492	57615	broad.mit.edu	37	chr19	22847727	22847727	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gataattcatactggagagaAaccctacaaatgtgaagaat	8	6	1	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr19:22847727A>C	uc002nqw.3	+	4	1500	c.1256A>C	c.(1255-1257)AAA>ACA	p.K419T		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACTGGAGAGAAACCCTACAAA	0.368													C	22847727	C	C	22847727	3	2	42	1	0	0	0	0	1	0	0	0	17940	14	1	5	1266	5	ZNF492	19	22847727	Missense_Mutation	SNP	A	TCGA-06-0195-01B-01D-1491-08	5538650	22847727	36281256	84	2673											
ZNF99	7652	broad.mit.edu	37	chr19	22941405	22941405	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttctaagggctgagaaacGcttaaaagctttgccacatt	8	8	1	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr19:22941405G>A	uc010xrh.1	-	5	1033	c.1033C>T	c.(1033-1035)CGT>TGT	p.R345C		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GCTGAGAAACGCTTAAAAGCT	0.373													A	22941405	A	A	22941405	3	1	42	1	0	0	0	0	1	0	0	0	18201	1087	38	1	2091	1	ZNF99	19	22941405	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	93678	22941405	36187578	85	2674											
TEAD2	8463	broad.mit.edu	37	chr19	49852054	49852054	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagcctgccaggctgggggcGatggggtaggtgggggcagg	24	7	0	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr19:49852054G>A	uc002pnj.2	-	8	732	c.641C>T	c.(640-642)TCG>TTG	p.S214L	TEAD2_uc002png.2_Missense_Mutation_p.S217L|TEAD2_uc002pnh.2_Missense_Mutation_p.S218L|TEAD2_uc002pni.2_Missense_Mutation_p.S217L|TEAD2_uc010yao.1_Missense_Mutation_p.S86L|TEAD2_uc010emw.2_Missense_Mutation_p.S217L	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	214	Transcriptional activation (Potential).|Pro-rich.				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		GGCTGGGGGCGATGGGGTAGG	0.572													A	49852054	A	A	49852054	3	1	42	1	0	0	0	0	1	0	0	0	15736	1059	37	2	722	2	TEAD2	19	49852054	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	26910649	49852054	9276929	86	2675											
SHANK1	50944	broad.mit.edu	37	chr19	51205802	51205802	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcacagccatgaaggagcGtccgggtaccgctgagtaga	13	11	1	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr19:51205802G>A	uc002psx.1	-	11	1688	c.1669C>T	c.(1669-1671)CGC>TGC	p.R557C		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	557	SH3.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ATGAAGGAGCGTCCGGGTACC	0.701													A	51205802	A	A	51205802	3	1	42	1	0	0	0	0	1	0	0	0	14264	1145	40	1	4868	1	SHANK1	19	51205802	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	1353748	51205802	7923181	87	2676											
FOXS1	2307	broad.mit.edu	37	chr20	30432906	30432906	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgagcactgcctgccggtcGtggcgttggggactcctggg	17	11	0	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr20:30432906G>A	uc002wwt.1	-	1	515	c.440C>T	c.(439-441)ACG>ATG	p.T147M		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	147					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1						CCTGCCGGTCGTGGCGTTGGG	0.687													A	30432906	A	A	30432906	3	1	42	1	0	0	0	0	1	0	0	0	6035	1145	40	1	556	1	FOXS1	20	30432906	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08		30432906	32592614	88	2677											
PLCG1	5335	broad.mit.edu	37	chr20	39802384	39802384	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttctgcgcttcgtggtgtatGaggaagacatgtttagtgac	13	6	1	3			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr20:39802384G>A	uc002xjp.1	+	29	3608	c.3487G>A	c.(3487-3489)GAG>AAG	p.E1163K	PLCG1_uc002xjo.1_Missense_Mutation_p.E1163K|PLCG1_uc010zwe.1_Missense_Mutation_p.E828K	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	1163	C2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				CGTGGTGTATGAGGAAGACAT	0.517											OREG0025953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	39802384	A	A	39802384	3	1	42	1	0	0	0	0	1	0	0	0	12035	1291	45	3	3601	3	PLCG1	20	39802384	Missense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08	9369478	39802384	23223136	89	2678											
SEMG1	6406	broad.mit.edu	37	chr20	43836216	43836216	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgaatgccctacataagaCgacaaaatcacaacgacatc	5	11	1	2			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr20:43836216C>T	uc002xni.2	+	2	335	c.278C>T	c.(277-279)ACG>ATG	p.T93M	SEMG1_uc002xnj.2_Missense_Mutation_p.T93M|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.T93M	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	93					insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				CTACATAAGACGACAAAATCA	0.378													T	43836216	T	T	43836216	3	4	42	1	0	0	0	0	1	0	0	0	14044	536	19	1	284	1	SEMG1	20	43836216	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	4033832	43836216	19189304	90	2679											
COL6A2	1292	broad.mit.edu	37	chr21	47539015	47539015	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagggcgggcctgggccccgCggacccaaaggcgagccggt	18	14	0	0	rs61735827	byFrequency	TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chr21:47539015C>T	uc002zia.1	+	14	1333	c.1251C>T	c.(1249-1251)CGC>CGT	p.R417R	COL6A2_uc002zhy.1_Silent_p.R417R|COL6A2_uc002zhz.1_Silent_p.R417R|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	417	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging	p.R417R(1)		central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CTGGGCCCCGCGGACCCAAAG	0.662													T	47539015	T	T	47539015	2	4	42	1	0	0	0	0	0	0	0	1	3700	755	27	1		1	COL6A2	21	47539015	Silent	SNP	C	TCGA-06-0195-01B-01D-1491-08		47539015	590880	91	2680											
BCOR	54880	broad.mit.edu	37	chrX	39931847	39931847	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatggtttgggatcctcttGggttttaccaaaagttacag	10	6	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chrX:39931847G>A	uc004den.3	-	4	3044	c.2752C>T	c.(2752-2754)CAA>TAA	p.Q918*	BCOR_uc004dep.3_Nonsense_Mutation_p.Q918*|BCOR_uc004deo.3_Nonsense_Mutation_p.Q918*|BCOR_uc004dem.3_Nonsense_Mutation_p.Q918*|BCOR_uc004deq.3_Nonsense_Mutation_p.Q918*	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	918					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						GGATCCTCTTGGGTTTTACCA	0.527													A	39931847	A	A	39931847	4	1	42	1	0	0	0	0	0	1	0	0	1386	1357	47	3	2563	3	BCOR	23	39931847	Nonsense_Mutation	SNP	G	TCGA-06-0195-01B-01D-1491-08		39931847	115338713	92	2681											
DGKK	139189	broad.mit.edu	37	chrX	50114831	50114831	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtctcatcctcagcacttctCagctggtacagacaggaaaa	8	12	3	1			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chrX:50114831C>T	uc010njr.1	-	27	3564	c.3504G>A	c.(3502-3504)CTG>CTA	p.L1168L		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1168					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					CAGCACTTCTCAGCTGGTACA	0.468													T	50114831	T	T	50114831	2	4	42	1	0	0	0	0	0	0	0	1	4472	813	29	3		3	DGKK	23	50114831	Silent	SNP	C	TCGA-06-0195-01B-01D-1491-08	10182984	50114831	105155729	93	2682											
GLUD2	2747	broad.mit.edu	37	chrX	120183088	120183088	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggcatacacaatggagcgttCtgccaggcaaattatgcaca	10	10	1	0			TCGA-06-0195-01B-01D-1491-08	TCGA-06-0195-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2fac52-44aa-41f7-ae27-de6b7eba8ff1	42bb2316-23da-407e-9ba0-058a781d0eb4	g.chrX:120183088C>A	uc004eto.2	+	1	1627	c.1550C>A	c.(1549-1551)TCT>TAT	p.S517Y		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	517					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATGGAGCGTTCTGCCAGGCAA	0.463													A	120183088	A	A	120183088	3	1	42	1	0	0	0	0	1	0	0	0	6477	913	32	5	1552	5	GLUD2	23	120183088	Missense_Mutation	SNP	C	TCGA-06-0195-01B-01D-1491-08	70068257	120183088	35087472	94	2683											
KIAA0467	23334	broad.mit.edu	37	chr1	43906999	43906999	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaaccgagagtgttcggactCctggtggagctgagcgggcg	17	9	0	2	rs150927632		TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr1:43906999C>T	uc001cjk.1	+	38	5224	c.4762C>T	c.(4762-4764)CCT>TCT	p.P1588S		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2487						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGTTCGGACTCCTGGTGGAGC	0.582													T	43906999	T	T	43906999	3	4	43	1	0	0	0	0	1	0	0	0	8178	855	30	3	4904	3	KIAA0467	1	43906999	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08		43906999	205343622	1	2684											
CYP4A11	1579	broad.mit.edu	37	chr1	47400170	47400170	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aaatccaaatgcctcttcctCttgatcttctccagctcccc	3	17	4	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr1:47400170C>G	uc001cqp.3	-	7	903	c.852G>C	c.(850-852)AAG>AAC	p.K284N	CYP4A11_uc001cqq.2_Missense_Mutation_p.K284N|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	284					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GCCTCTTCCTCTTGATCTTCT	0.498													G	47400170	G	G	47400170	3	3	43	1	0	0	0	0	1	0	0	0	4183	912	32	5	731	5	CYP4A11	1	47400170	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	3493171	47400170	201850451	2	2685											
C1orf175	374977	broad.mit.edu	37	chr1	55136211	55136211	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggattctctctcaagctcCgtccgcaagcaggccatgga	10	14	2	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr1:55136211C>T	uc010ooe.1	+	6	1755	c.1431C>T	c.(1429-1431)TCC>TCT	p.S477S	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Silent_p.S45S|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_5'UTR|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Silent_p.S477S|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_Intron|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	477						integral to membrane	binding				0						TCTCAAGCTCCGTCCGCAAGC	0.473													T	55136211	T	T	55136211	2	4	43	1	0	0	0	0	0	0	0	1	2016	639	23	2		2	C1orf175	1	55136211	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08	7736041	55136211	194114410	3	2686											
CSDE1	7812	broad.mit.edu	37	chr1	115269683	115269683	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcagtttcaccccacagtcaTcataagcaataatgccatcc	4	14	4	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr1:115269683T>C	uc001efk.2	-	13	1851	c.1385A>G	c.(1384-1386)GAT>GGT	p.D462G	CSDE1_uc001efi.2_Missense_Mutation_p.D508G|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.D431G|CSDE1_uc001efm.2_Missense_Mutation_p.D477G|CSDE1_uc009wgv.2_Missense_Mutation_p.D462G|CSDE1_uc001efn.2_Missense_Mutation_p.D431G	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	462	CSD 6.				male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCACAGTCATCATAAGCAAT	0.373													C	115269683	C	C	115269683	3	2	43	1	0	0	0	0	1	0	0	0	3929	1435	50	4	1043	4	CSDE1	1	115269683	Missense_Mutation	SNP	T	TCGA-06-0209-01A-01D-1491-08	60133472	115269683	133980938	4	2687											
TCHH	7062	broad.mit.edu	37	chr1	152084091	152084091	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgcgtcttagttgttgctcGctcctcaaccgctgctggag	11	13	2	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr1:152084091G>A	uc001ezp.2	-	2	1602	c.1602C>T	c.(1600-1602)AGC>AGT	p.S534S	TCHH_uc009wne.1_Silent_p.S534S	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	534	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTGTTGCTCGCTCCTCAACC	0.652													A	152084091	A	A	152084091	2	1	43	1	0	0	0	0	0	0	0	1	15697	1078	38	1		1	TCHH	1	152084091	Silent	SNP	G	TCGA-06-0209-01A-01D-1491-08	36814408	152084091	97166530	5	2688											
OR10Z1	128368	broad.mit.edu	37	chr1	158577031	158577032	+	Frame_Shift_Del	DEL	TT	-	-													gcccaaagccagctactctcTtgagagagatcagcttattg							TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr1:158577031_158577032delTT	uc010pio.1	+	1	803_804	c.803_804delTT	c.(802-804)CTTfs	p.L268fs		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					AGCTACTCTCTTGAGAGAGATC	0.47													-	158577032	-	-	158577031	7	5	43	1	0	1	0	1	0	0	0	0	10923	1609	56	0	805	0	OR10Z1	1	158577031	Frame_Shift_Del	DEL	TT	TCGA-06-0209-01A-01D-1491-08	6492940	158577031	90673590	6	2689											
LGR6	59352	broad.mit.edu	37	chr1	202287327	202287327	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggtcagttctctgagtaCggagcccgctgggagacggg	16	9	2	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr1:202287327C>T	uc001gxu.2	+	18	1896	c.1896C>T	c.(1894-1896)TAC>TAT	p.Y632Y	LGR6_uc001gxv.2_Silent_p.Y580Y|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.Y493Y	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	632	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TCTCTGAGTACGGAGCCCGCT	0.622													T	202287327	T	T	202287327	2	4	43	1	0	0	0	0	0	0	0	1	8758	547	19	1		1	LGR6	1	202287327	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08	43710296	202287327	46963294	7	2690											
OR1C1	26188	broad.mit.edu	37	chr1	247921487	247921487	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttgggggactgtagtcgaCgtaaagcagatgtcaacaaa	12	6	1	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr1:247921487C>T	uc010pza.1	-	1	222	c.222G>A	c.(220-222)ACG>ACA	p.T74T		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CTGTAGTCGACGTAAAGCAGA	0.463													T	247921487	T	T	247921487	2	4	43	1	0	0	0	0	0	0	0	1	10952	523	19	1		1	OR1C1	1	247921487	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08	45634160	247921487	1329134	8	2691											
APOB	338	broad.mit.edu	37	chr2	21255225	21255225	+	Splice_Site	DEL	C	-	-													aaatacagtgtggaaactcaCttgttgaccgcgtggctcag							TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr2:21255225delC	uc002red.2	-	10	1480	c.1352_splice	c.e10+1	p.N451_splice		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor						cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGAAACTCACTTGTTGACCG	0.537													-	21255225	-	-	21255225	8	5	43	1	0	1	0	1	0	0	1	0	785	579	20	0	12418	0	APOB	2	21255225	Splice_Site	DEL	C	TCGA-06-0209-01A-01D-1491-08		21255225	221944148	9	2692											
GLI2	2736	broad.mit.edu	37	chr2	121747197	121747197	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcaggcagccagtgtcctgGcatgactaccactatgagcc	12	13	0	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr2:121747197G>A	uc010flp.2	+	13	3737	c.3707G>A	c.(3706-3708)GGC>GAC	p.G1236D	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.G908D|GLI2_uc002tmu.3_Missense_Mutation_p.G891D	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1236					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CAGTGTCCTGGCATGACTACC	0.652													A	121747197	A	A	121747197	3	1	43	1	0	0	0	0	1	0	0	0	6438	1203	42	3	3757	3	GLI2	2	121747197	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	100491972	121747197	121452176	10	2693											
POTEF	728378	broad.mit.edu	37	chr2	130877687	130877687	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tccagatcttctccacggacGtggtacctgggctccatgaa	10	13	2	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr2:130877687G>C	uc010fmh.2	-	3	802	c.402C>G	c.(400-402)CAC>CAG	p.H134Q		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	134						cell cortex	ATP binding			skin(3)|ovary(2)	5						CTCCACGGACGTGGTACCTGG	0.592													C	130877687	C	C	130877687	3	2	43	1	0	0	0	0	1	0	0	0	12265	1136	40	5	2885	5	POTEF	2	130877687	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	9130490	130877687	112321686	11	2694											
FAM123C	205147	broad.mit.edu	37	chr2	131522112	131522112	+	Frame_Shift_Del	DEL	G	-	-													ctttgaacagccagcaggaaGggggggtctctgcaagtgcc							TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr2:131522112delG	uc002trw.2	+	2	2657	c.2467delG	c.(2467-2469)GGGfs	p.G823fs	FAM123C_uc010fmv.2_Frame_Shift_Del_p.G823fs|FAM123C_uc010fms.1_Frame_Shift_Del_p.G823fs|FAM123C_uc010fmt.1_Frame_Shift_Del_p.G823fs|FAM123C_uc010fmu.1_Frame_Shift_Del_p.G823fs	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	823										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CCAGCAGGAAGGGGGGGTCTC	0.677													-	131522112	-	-	131522112	7	5	43	1	0	1	0	1	0	0	0	0	5424	1000	35	0	2469	0	FAM123C	2	131522112	Frame_Shift_Del	DEL	G	TCGA-06-0209-01A-01D-1491-08	644425	131522112	111677261	12	2695											
KCNJ3	3760	broad.mit.edu	37	chr2	155711294	155711294	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatgaagttctttggggtcaTcgtttttttcctgtaatttc	9	6	2	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr2:155711294T>C	uc002tyv.1	+	3	1170	c.975T>C	c.(973-975)CAT>CAC	p.H325H	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	325	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	TTTGGGGTCATCGTTTTTTTC	0.383													C	155711294	C	C	155711294	2	2	43	1	0	0	0	0	0	0	0	1	8052	1432	50	4		4	KCNJ3	2	155711294	Silent	SNP	T	TCGA-06-0209-01A-01D-1491-08	24189182	155711294	87488079	13	2696											
UPP2	151531	broad.mit.edu	37	chr2	158971751	158971751	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatactgtatgtacaaaaccGggcctgtgctcgccatcagt	10	11	1	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr2:158971751G>A	uc002tzp.2	+	3	513	c.319G>A	c.(319-321)GGG>AGG	p.G107R	UPP2_uc002tzo.2_Missense_Mutation_p.G164R	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	107					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						GTACAAAACCGGGCCTGTGCT	0.438													A	158971751	A	A	158971751	3	1	43	1	0	0	0	0	1	0	0	0	17010	1116	39	2	508	2	UPP2	2	158971751	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	3260457	158971751	84227622	14	2697											
ITGB6	3694	broad.mit.edu	37	chr2	160964323	160964323	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagccagggaaacccctaacAtgatcatgggaatgtttgga	11	8	1	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr2:160964323A>G	uc002ubh.2	-	14	2151	c.2135T>C	c.(2134-2136)ATG>ACG	p.M712T	ITGB6_uc010fou.2_Missense_Mutation_p.M712T|ITGB6_uc010zcq.1_Missense_Mutation_p.M670T|ITGB6_uc010fov.1_Missense_Mutation_p.M712T	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	712	Helical; (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						AACCCCTAACATGATCATGGG	0.403													G	160964323	G	G	160964323	3	3	43	1	0	0	0	0	1	0	0	0	7899	217	8	4	239	4	ITGB6	2	160964323	Missense_Mutation	SNP	A	TCGA-06-0209-01A-01D-1491-08	1992572	160964323	82235050	15	2698											
TTN	7273	broad.mit.edu	37	chr2	179431071	179431071	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaattccttttcttaattcGgagtcaaggtcaagttcagg	8	8	4	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr2:179431071G>A	uc010zfg.1	-	275	72308	c.72084C>T	c.(72082-72084)TCC>TCT	p.S24028S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.S17723S|TTN_uc010zfi.1_Silent_p.S17656S|TTN_uc010zfj.1_Silent_p.S17531S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24955							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTAATTCGGAGTCAAGGT	0.453													A	179431071	A	A	179431071	2	1	43	1	0	0	0	0	0	0	0	1	16732	1103	39	2		2	TTN	2	179431071	Silent	SNP	G	TCGA-06-0209-01A-01D-1491-08	18466748	179431071	63768302	16	2699											
UGT1A1	54658	broad.mit.edu	37	chr2	234669059	234669059	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatggcagccactggctgagCatgcttggggccatccagca	14	12	0	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr2:234669059C>T	uc002vvb.2	+	1	141	c.126C>T	c.(124-126)AGC>AGT	p.S42S	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Silent_p.S42S	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	42					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	ACTGGCTGAGCATGCTTGGGG	0.577													T	234669059	T	T	234669059	2	4	43	1	0	0	0	0	0	0	0	1	16941	709	25	3		3	UGT1A1	2	234669059	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08	55237988	234669059	8530314	17	2700											
COL7A1	1294	broad.mit.edu	37	chr3	48629808	48629808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggacccgccatgtcacacGgtagccagtggcacctggca	13	14	1	0	rs146041612		TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr3:48629808G>A	uc003ctz.2	-	8	1070	c.1069C>T	c.(1069-1071)CGT>TGT	p.R357C		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	357	Nonhelical region (NC1).|Fibronectin type-III 2.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CATGTCACACGGTAGCCAGTG	0.637													A	48629808	A	A	48629808	3	1	43	1	0	0	0	0	1	0	0	0	3704	1116	39	2	8209	2	COL7A1	3	48629808	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08		48629808	149392622	18	2701											
IFT57	55081	broad.mit.edu	37	chr3	107938379	107938379	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agcaagagtacaaaacatgtAgaactgttcgccagggttgg	12	7	0	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr3:107938379A>T	uc003dwx.3	-	2	501	c.253T>A	c.(253-255)TAC>AAC	p.Y85N		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	85					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			CAAAACATGTAGAACTGTTCG	0.408													T	107938379	T	T	107938379	3	4	43	1	0	0	0	0	1	0	0	0	7562	420	15	5	1076	5	IFT57	3	107938379	Missense_Mutation	SNP	A	TCGA-06-0209-01A-01D-1491-08	59308571	107938379	90084051	19	2702											
COL6A6	131873	broad.mit.edu	37	chr3	130354555	130354555	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtatttagggtgagattgggGaccctggtggtccaggagag	18	5	0	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr3:130354555G>A	uc010htl.2	+	27	5072	c.5041G>A	c.(5041-5043)GAC>AAC	p.D1681N	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1681	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TGAGATTGGGGACCCTGGTGG	0.373													A	130354555	A	A	130354555	3	1	43	1	0	0	0	0	1	0	0	0	3703	1174	41	3	5147	3	COL6A6	3	130354555	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	22416176	130354555	67667875	20	2703											
FRAS1	80144	broad.mit.edu	37	chr4	79399128	79399128	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggtcattatcaacgataccGaggatgaacccacattagag	9	9	2	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr4:79399128G>A	uc003hlb.2	+	55	8451	c.8011G>A	c.(8011-8013)GAG>AAG	p.E2671K		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2666	Extracellular (Potential).|Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CAACGATACCGAGGATGAACC	0.458													A	79399128	A	A	79399128	3	1	43	1	0	0	0	0	1	0	0	0	6042	1059	37	2	8304	2	FRAS1	4	79399128	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08		79399128	111755148	21	2704											
NR3C2	4306	broad.mit.edu	37	chr4	149073647	149073647	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agactaggtctggtgcaaaaTagagaaattggctgttcgta	12	5	1	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr4:149073647T>C	uc003ilj.3	-	6	2817	c.2483A>G	c.(2482-2484)TAT>TGT	p.Y828C	NR3C2_uc003ilk.3_Missense_Mutation_p.Y711C|NR3C2_uc010iph.2_Intron	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	828	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TGGTGCAAAATAGAGAAATTG	0.358													C	149073647	C	C	149073647	3	2	43	1	0	0	0	0	1	0	0	0	10631	1406	49	4	487	4	NR3C2	4	149073647	Missense_Mutation	SNP	T	TCGA-06-0209-01A-01D-1491-08	69674519	149073647	42080629	22	2705											
ADAM29	11086	broad.mit.edu	37	chr4	175897719	175897719	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatgatgaggatacatgtcGttgttcacaacctagatgca	9	9	1	3			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr4:175897719G>A	uc003iuc.2	+	5	1713	c.1043G>A	c.(1042-1044)CGT>CAT	p.R348H	ADAM29_uc003iud.2_Missense_Mutation_p.R348H|ADAM29_uc010irr.2_Missense_Mutation_p.R348H|ADAM29_uc011cki.1_Missense_Mutation_p.R348H	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	348	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GATACATGTCGTTGTTCACAA	0.373													A	175897719	A	A	175897719	3	1	43	1	0	0	0	0	1	0	0	0	247	1145	40	1	1045	1	ADAM29	4	175897719	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	26824072	175897719	15256557	23	2706											
KIF3A	11127	broad.mit.edu	37	chr5	132038627	132038627	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctctgctcttttcctcctttCttccagttccatgttagatt	4	13	3	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr5:132038627C>A	uc003kxo.2	-	11	1670	c.1516G>T	c.(1516-1518)GAA>TAA	p.E506*	KIF3A_uc003kxm.2_Nonsense_Mutation_p.E88*|KIF3A_uc003kxn.2_Nonsense_Mutation_p.E491*|KIF3A_uc011cxf.1_Nonsense_Mutation_p.E533*|KIF3A_uc003kxp.2_Nonsense_Mutation_p.E509*	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	506	Potential.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTCCTCCTTTCTTCCAGTTCC	0.408													A	132038627	A	A	132038627	4	1	43	1	0	0	0	0	0	1	0	0	8300	922	32	5	611	5	KIF3A	5	132038627	Nonsense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08		132038627	48876633	24	2707											
SPOCK1	6695	broad.mit.edu	37	chr5	136324273	136324273	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaggtcatagttcatgtccaActtgttgaacatccagccca	8	11	2	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr5:136324273A>G	uc003lbo.2	-	7	957	c.766T>C	c.(766-768)TTG>CTG	p.L256L	SPOCK1_uc003lbp.2_Silent_p.L256L	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	256					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTCATGTCCAACTTGTTGAAC	0.498													G	136324273	G	G	136324273	2	3	43	1	0	0	0	0	0	0	0	1	15078	40	2	4		4	SPOCK1	5	136324273	Silent	SNP	A	TCGA-06-0209-01A-01D-1491-08	4285646	136324273	44590987	25	2708											
ETF1	2107	broad.mit.edu	37	chr5	137848498	137848498	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agttcagttttaaagtcagcGgatccagctaaaactagacc	8	9	2	1	rs145474099	byFrequency	TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr5:137848498G>T	uc003ldc.3	-	6	852	c.687C>A	c.(685-687)TCC>TCA	p.S229S	ETF1_uc011cyv.1_Silent_p.S215S|ETF1_uc010jex.2_RNA|ETF1_uc003ldd.3_Silent_p.S196S|ETF1_uc010jey.1_Silent_p.S35S	NM_004730	NP_004721	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	229					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TAAAGTCAGCGGATCCAGCTA	0.403													T	137848498	T	T	137848498	2	4	43	1	0	0	0	0	0	0	0	1	5268	1103	39	5		5	ETF1	5	137848498	Silent	SNP	G	TCGA-06-0209-01A-01D-1491-08	1524225	137848498	43066762	26	2709											
PCDHA2	56146	broad.mit.edu	37	chr5	140176802	140176802	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggggagctggtcttactcGcagcagaggcggcagagggt	19	8	1	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr5:140176802G>A	uc003lhd.2	+	1	2359	c.2253G>A	c.(2251-2253)TCG>TCA	p.S751S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.S751S|PCDHA2_uc011czy.1_Silent_p.S751S	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	751	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTCTTACTCGCAGCAGAGGC	0.672													A	140176802	A	A	140176802	2	1	43	1	0	0	0	0	0	0	0	1	11524	1074	38	1		1	PCDHA2	5	140176802	Silent	SNP	G	TCGA-06-0209-01A-01D-1491-08	2328304	140176802	40738458	27	2710											
ARAP3	64411	broad.mit.edu	37	chr5	141041288	141041288	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagggtggccagtgtgcggcGgttgacccgcggcaggcagc	20	11	0	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr5:141041288G>A	uc003llm.2	-	21	3160	c.3082C>T	c.(3082-3084)CGC>TGC	p.R1028C	ARAP3_uc003lll.2_5'UTR|ARAP3_uc011dbe.1_Missense_Mutation_p.R690C|ARAP3_uc003lln.2_Missense_Mutation_p.R859C	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1028	Rho-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						AGTGTGCGGCGGTTGACCCGC	0.552													A	141041288	A	A	141041288	3	1	43	1	0	0	0	0	1	0	0	0	840	1116	39	2	1604	2	ARAP3	5	141041288	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	864486	141041288	39873972	28	2711											
ZNF165	7718	broad.mit.edu	37	chr6	28053436	28053436	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcagttctgctaccaggatTctcctggacctcgcgaggca	12	13	2	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr6:28053436T>C	uc003nkg.2	+	3	1262	c.178T>C	c.(178-180)TCT>CCT	p.S60P	ZNF165_uc003nkh.2_Missense_Mutation_p.S60P|ZNF165_uc003nki.3_Missense_Mutation_p.S60P	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	60					viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CTACCAGGATTCTCCTGGACC	0.537													C	28053436	C	C	28053436	3	2	43	1	0	0	0	0	1	0	0	0	17737	1783	62	4	180	4	ZNF165	6	28053436	Missense_Mutation	SNP	T	TCGA-06-0209-01A-01D-1491-08		28053436	143061631	29	2712											
ITPR3	3710	broad.mit.edu	37	chr6	33653482	33653482	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcgctgggccccagcctgCgccgggggcacgaggtgagc	17	15	0	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr6:33653482C>T	uc011drk.1	+	41	5764	c.5545C>T	c.(5545-5547)CGC>TGC	p.R1849C	ITPR3_uc003oey.2_5'Flank	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1849	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding	p.R1849C(1)		ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CCCCAGCCTGCGCCGGGGGCA	0.662													T	33653482	T	T	33653482	3	4	43	1	0	0	0	0	1	0	0	0	7922	768	27	1	5707	1	ITPR3	6	33653482	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	5600046	33653482	137461585	30	2713											
SNAP91	9892	broad.mit.edu	37	chr6	84292053	84292053	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcactggagatggggaaggCgccatgaaagaacccccaaa	13	10	1	3			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr6:84292053C>T	uc011dze.1	-	22	2354	c.2037G>A	c.(2035-2037)GCG>GCA	p.A679A	SNAP91_uc011dzd.1_Silent_p.A182A|SNAP91_uc003pkb.2_Silent_p.A588A|SNAP91_uc003pkc.2_Silent_p.A649A|SNAP91_uc003pkd.2_Silent_p.A372A|SNAP91_uc003pka.2_Silent_p.A677A	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	679					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		ATGGGGAAGGCGCCATGAAAG	0.433													T	84292053	T	T	84292053	2	4	43	1	0	0	0	0	0	0	0	1	14833	755	27	1		1	SNAP91	6	84292053	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08	50638571	84292053	86823014	31	2714											
PM20D2	135293	broad.mit.edu	37	chr6	89868090	89868090	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttattacaatgttcttcccaAtaagagcctatggaaagcct	6	9	1	1	rs141826904	byFrequency	TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr6:89868090A>G	uc003pmz.2	+	5	1054	c.959A>G	c.(958-960)AAT>AGT	p.N320S		NM_001010853	NP_001010853	Q8IYS1	P20D2_HUMAN	aminoacylase 1-like 2	320							hydrolase activity				0		all_cancers(76;9.47e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00813)		GTTCTTCCCAATAAGAGCCTA	0.318													G	89868090	G	G	89868090	3	3	43	1	0	0	0	0	1	0	0	0	12129	101	4	4	977	4	PM20D2	6	89868090	Missense_Mutation	SNP	A	TCGA-06-0209-01A-01D-1491-08	5576037	89868090	81246977	32	2715											
SIM1	6492	broad.mit.edu	37	chr6	100841583	100841583	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accagcctcgagtggtcaagCgcaaagccatagcagagaga	12	11	1	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr6:100841583C>T	uc003pqj.3	-	10	1557	c.1350G>A	c.(1348-1350)GCG>GCA	p.A450A	SIM1_uc010kcu.2_Silent_p.A450A	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	450	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AGTGGTCAAGCGCAAAGCCAT	0.622													T	100841583	T	T	100841583	2	4	43	1	0	0	0	0	0	0	0	1	14323	755	27	1		1	SIM1	6	100841583	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08	10973493	100841583	70273484	33	2716											
BCLAF1	9774	broad.mit.edu	37	chr6	136599630	136599630	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagaagatctatatgaccggCgagatctgcttctggatctt	10	8	4	4	rs147614051		TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr6:136599630C>T	uc003qgx.1	-	4	642	c.389G>A	c.(388-390)CGC>CAC	p.R130H	BCLAF1_uc003qgw.1_Missense_Mutation_p.R130H|BCLAF1_uc003qgy.1_Missense_Mutation_p.R128H|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R128H	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	130					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ATATGACCGGCGAGATCTGCT	0.458													T	136599630	T	T	136599630	3	4	43	1	0	0	0	0	1	0	0	0	1383	768	27	1	2413	1	BCLAF1	6	136599630	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	35758047	136599630	34515437	34	2717											
OPRM1	4988	broad.mit.edu	37	chr6	154412347	154412347	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggactcccattcacatttacGtcatcattaaagccttggtt	6	11	3	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr6:154412347G>A	uc003qpr.2	+	3	1141	c.904G>A	c.(904-906)GTC>ATC	p.V302I	OPRM1_uc011efc.1_Missense_Mutation_p.V221I|OPRM1_uc011efd.1_Missense_Mutation_p.V202I|OPRM1_uc011efe.1_Missense_Mutation_p.V395I|OPRM1_uc003qpn.2_Missense_Mutation_p.V302I|OPRM1_uc003qpo.1_Missense_Mutation_p.V302I|OPRM1_uc011eff.1_Missense_Mutation_p.V302I|OPRM1_uc011efg.1_Missense_Mutation_p.V302I|OPRM1_uc011efh.1_Missense_Mutation_p.V302I|OPRM1_uc003qpq.1_Missense_Mutation_p.V302I|OPRM1_uc003qpt.1_Missense_Mutation_p.V302I|OPRM1_uc011efi.1_Missense_Mutation_p.V302I|OPRM1_uc003qpp.2_RNA|OPRM1_uc003qps.2_RNA|OPRM1_uc010kjg.2_Missense_Mutation_p.V202I|OPRM1_uc003qpu.2_Missense_Mutation_p.V202I	NM_000914	NP_000905	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1	302	Helical; Name=6; (Potential).				behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	TCACATTTACGTCATCATTAA	0.483													A	154412347	A	A	154412347	3	1	43	1	0	0	0	0	1	0	0	0	10887	1145	40	1	1248	1	OPRM1	6	154412347	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	17812717	154412347	16702720	35	2718											
SDK1	221935	broad.mit.edu	37	chr7	4011107	4011107	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gtttttttcagatcggacgtCcatcgtccaccctcctgagg	9	13	1	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:4011107C>A	uc003smx.2	+	12	1863	c.1724C>A	c.(1723-1725)TCC>TAC	p.S575Y		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	575	Ig-like C2-type 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GATCGGACGTCCATCGTCCAC	0.552													A	4011107	A	A	4011107	3	1	43	1	0	0	0	0	1	0	0	0	13968	855	30	5	1770	5	SDK1	7	4011107	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08		4011107	155127556	36	2719											
IKZF1	10320	broad.mit.edu	37	chr7	50468038	50468038	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgccccgcacgcgcgcaacGggctgtcgctcaaggaggag	15	15	1	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:50468038G>A	uc003tow.3	+	9	1441	c.1273G>A	c.(1273-1275)GGG>AGG	p.G425R	IKZF1_uc003tox.3_Missense_Mutation_p.G383R|IKZF1_uc003toy.3_Missense_Mutation_p.G383R|IKZF1_uc011kck.1_Missense_Mutation_p.G338R|IKZF1_uc003toz.3_Missense_Mutation_p.G395R|IKZF1_uc010kyx.2_Missense_Mutation_p.G165R|IKZF1_uc003tpa.3_Missense_Mutation_p.G167R	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	425				PHARNGL -> RRAQRV (in Ref. 2; AAB50683).	cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CGCGCGCAACGGGCTGTCGCT	0.677			D		ALL								A	50468038	A	A	50468038	3	1	43	1	0	0	0	0	1	0	0	0	7614	1116	39	2	1299	2	IKZF1	7	50468038	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	46456931	50468038	108670625	37	2720											
VSTM2A	222008	broad.mit.edu	37	chr7	54636702	54636702	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcttataacttcttccgcagGtgcgaggatagctacaagcc	9	11	2	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:54636702G>C	uc010kzf.2	+	5	1040	c.635G>C	c.(634-636)GGT>GCT	p.G212A	VSTM2A_uc003tqc.3_Intron|uc003tqd.2_5'Flank	NM_182546	NP_872352	Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2	212						extracellular region					0			STAD - Stomach adenocarcinoma(5;0.0525)			TCTTCCGCAGGTGCGAGGATA	0.383													C	54636702	C	C	54636702	3	2	43	1	0	0	0	0	1	0	0	0	17226	1275	44	5	653	5	VSTM2A	7	54636702	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	4168664	54636702	104501961	38	2721											
CALCR	799	broad.mit.edu	37	chr7	93106887	93106887	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctgatggatcaaaatccGgaaaataatctgggcagaac	9	8	2	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:93106887G>A	uc003umv.1	-	5	614	c.353C>T	c.(352-354)CCG>CTG	p.P118L	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.P100L|CALCR_uc003umw.2_Missense_Mutation_p.P100L	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	100	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	ATCAAAATCCGGAAAATAATC	0.413													A	93106887	A	A	93106887	3	1	43	1	0	0	0	0	1	0	0	0	2579	1116	39	2	1217	2	CALCR	7	93106887	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	38470185	93106887	66031776	39	2722											
ZAN	7455	broad.mit.edu	37	chr7	100357434	100357434	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacgtgaccctgcccgagaGcaccgtcaccctgcttaagg	10	16	1	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:100357434G>A	uc003uwj.2	+	18	3827	c.3662G>A	c.(3661-3663)AGC>AAC	p.S1221N	ZAN_uc003uwk.2_Missense_Mutation_p.S1221N|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_5'Flank	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1221	VWFD 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTGCCCGAGAGCACCGTCACC	0.602													A	100357434	A	A	100357434	3	1	43	1	0	0	0	0	1	0	0	0	17510	971	34	3	3728	3	ZAN	7	100357434	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	7250547	100357434	58781229	40	2723											
C7orf58	79974	broad.mit.edu	37	chr7	120655897	120655897	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctagggccggggctactagAacaaggtcagaatagtgaga	14	8	1	3			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:120655897A>G	uc003vjq.3	+	3	875	c.428A>G	c.(427-429)GAA>GGA	p.E143G	C7orf58_uc003vjr.1_Missense_Mutation_p.E143G|C7orf58_uc003vjs.3_Missense_Mutation_p.E143G	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	143						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					GGGCTACTAGAACAAGGTCAG	0.423													G	120655897	G	G	120655897	3	3	43	1	0	0	0	0	1	0	0	0	2405	246	9	4	434	4	C7orf58	7	120655897	Missense_Mutation	SNP	A	TCGA-06-0209-01A-01D-1491-08	20298463	120655897	38482766	41	2724											
JHDM1D	80853	broad.mit.edu	37	chr7	139826573	139826573	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catctggccaataattttccAcccaggaaagttttttggct	7	10	1	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:139826573A>T	uc003vvm.2	-	6	756	c.752T>A	c.(751-753)GTG>GAG	p.V251E		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	251	JmjC.				midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					ATAATTTTCCACCCAGGAAAG	0.378													T	139826573	T	T	139826573	3	4	43	1	0	0	0	0	1	0	0	0	7948	159	6	5	2133	5	JHDM1D	7	139826573	Missense_Mutation	SNP	A	TCGA-06-0209-01A-01D-1491-08	19170676	139826573	19312090	42	2725											
GSTK1	373156	broad.mit.edu	37	chr7	142964771	142964771	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttctggaaaagatcgcaaCgccaaaggtgaagaaccagc	10	10	1	3	rs41275042	byFrequency	TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:142964771C>T	uc003wci.2	+	6	567	c.482C>T	c.(481-483)ACG>ATG	p.T161M	GSTK1_uc011ksy.1_Missense_Mutation_p.T118M|GSTK1_uc003wcj.2_Missense_Mutation_p.T217M|GSTK1_uc011ksz.1_Missense_Mutation_p.T149M	NM_015917	NP_057001	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1 isoform a	161						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity				0	Melanoma(164;0.059)				Glutathione(DB00143)	AAGATCGCAACGCCAAAGGTG	0.512													T	142964771	T	T	142964771	3	4	43	1	0	0	0	0	1	0	0	0	6836	536	19	1	668	1	GSTK1	7	142964771	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	3138198	142964771	16173892	43	2726											
NOBOX	135935	broad.mit.edu	37	chr7	144098495	144098495	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttgtggggagccctggagCgggggggcgggcacagtctc	20	10	1	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:144098495C>T	uc011kue.1	-	4	488	c.488G>A	c.(487-489)CGC>CAC	p.R163H		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	163					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					AGCCCTGGAGCGGGGGGGCGG	0.627													T	144098495	T	T	144098495	3	4	43	1	0	0	0	0	1	0	0	0	10512	768	27	1	1519	1	NOBOX	7	144098495	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	1133724	144098495	15040168	44	2727											
AGAP3	116988	broad.mit.edu	37	chr7	150840441	150840441	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgcagagaggagaaggaaCgctggatacgggccaagtat	16	6	0	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:150840441C>T	uc003wjg.1	+	17	2290	c.2287C>T	c.(2287-2289)CGC>TGC	p.R763C	AGAP3_uc003wje.1_Missense_Mutation_p.R432C|AGAP3_uc003wjj.1_Missense_Mutation_p.R262C|AGAP3_uc003wjk.1_Missense_Mutation_p.R181C	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	727	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						GGAGAAGGAACGCTGGATACG	0.617													T	150840441	T	T	150840441	3	4	43	1	0	0	0	0	1	0	0	0	369	536	19	1	2420	1	AGAP3	7	150840441	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	6741946	150840441	8298222	45	2728											
RBM33	155435	broad.mit.edu	37	chr7	155538204	155538204	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cccaggacacaaagcctggcGtgaaaaggactgtcacgcac	11	13	1	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr7:155538204G>T	uc010lqk.1	+	14	3255	c.2887G>T	c.(2887-2889)GTG>TTG	p.V963L	RBM33_uc011kvv.1_Missense_Mutation_p.V772L|RBM33_uc003wmg.2_5'Flank	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	963							nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		AAAGCCTGGCGTGAAAAGGAC	0.602													T	155538204	T	T	155538204	3	4	43	1	0	0	0	0	1	0	0	0	13130	1145	40	5	2941	5	RBM33	7	155538204	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	4697763	155538204	3600459	46	2729											
RB1CC1	9821	broad.mit.edu	37	chr8	53571454	53571454	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgaggaatggctgaacttccGaaggacaaaatgattgcaga	12	6	0	4			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr8:53571454G>A	uc003xre.3	-	13	2330	c.1772C>T	c.(1771-1773)TCG>TTG	p.S591L	RB1CC1_uc003xrf.3_Missense_Mutation_p.S591L	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	591					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CTGAACTTCCGAAGGACAAAA	0.323													A	53571454	A	A	53571454	3	1	43	1	0	0	0	0	1	0	0	0	13099	1059	37	2	3060	2	RB1CC1	8	53571454	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08		53571454	92792568	47	2730											
C10orf2	56652	broad.mit.edu	37	chr10	102749558	102749558	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaggggcggctggaagatcaActggacaaatatgatcactg	14	7	2	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr10:102749558A>G	uc001ksf.2	+	2	2076	c.1401A>G	c.(1399-1401)CAA>CAG	p.Q467Q	MRPL43_uc001kry.1_5'Flank|MRPL43_uc010qpu.1_5'Flank|MRPL43_uc001krz.1_5'Flank|MRPL43_uc001ksa.1_5'Flank|MRPL43_uc001ksb.1_5'Flank|MRPL43_uc001ksd.1_5'Flank|MRPL43_uc001ksc.2_5'Flank|MRPL43_uc001kse.2_5'Flank|C10orf2_uc001ksg.2_Silent_p.Q467Q|C10orf2_uc001ksi.2_Silent_p.Q13Q|C10orf2_uc010qpv.1_Silent_p.Q13Q|C10orf2_uc001ksh.2_RNA	NM_021830	NP_068602	Q96RR1	PEO1_HUMAN	twinkle isoform A	467	SF4 helicase.				cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			ovary(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TGGAAGATCAACTGGACAAAT	0.542													G	102749558	G	G	102749558	2	3	43	1	0	0	0	0	0	0	0	1	1597	40	2	4		4	C10orf2	10	102749558	Silent	SNP	A	TCGA-06-0209-01A-01D-1491-08		102749558	32785189	48	2731											
OR56A4	120793	broad.mit.edu	37	chr11	6024337	6024337	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgggtttccactgaggccCtgtatctgtcccaataaagt	10	10	1	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr11:6024337C>T	uc010qzv.1	-	1	42	c.42G>A	c.(40-42)CAG>CAA	p.Q14Q		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	Error:Variant_position_missing_in_Q8NGH8_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACTGAGGCCCTGTATCTGTC	0.299													T	6024337	T	T	6024337	2	4	43	1	0	0	0	0	0	0	0	1	11135	680	24	3		3	OR56A4	11	6024337	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08		6024337	128982179	49	2732											
OR4P4	81300	broad.mit.edu	37	chr11	55406071	55406071	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccacagtgacccccaaattaAtggttgacttactggcagaa	8	11	0	3			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr11:55406071A>G	uc010rij.1	+	1	238	c.238A>G	c.(238-240)ATG>GTG	p.M80V		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						CCCCAAATTAATGGTTGACTT	0.413													G	55406071	G	G	55406071	3	3	43	1	0	0	0	0	1	0	0	0	11080	101	4	4	240	4	OR4P4	11	55406071	Missense_Mutation	SNP	A	TCGA-06-0209-01A-01D-1491-08	49381734	55406071	79600445	50	2733											
GLYATL1	92292	broad.mit.edu	37	chr11	58723260	58723260	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggtctcatgggtaaccatGgacccttcttgtgaagtagg	12	10	2	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr11:58723260G>A	uc001nnf.2	+	8	1045	c.669G>A	c.(667-669)ATG>ATA	p.M223I	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.M254I|GLYATL1_uc001nni.1_Missense_Mutation_p.M223I|GLYATL1_uc001nnj.1_Missense_Mutation_p.M223I			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	223						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	GGGTAACCATGGACCCTTCTT	0.522													A	58723260	A	A	58723260	3	1	43	1	0	0	0	0	1	0	0	0	6480	1348	47	3	788	3	GLYATL1	11	58723260	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	3317189	58723260	76283256	51	2734											
TRPC6	7225	broad.mit.edu	37	chr11	101347101	101347101	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cttcaaagtatcatttgcgtCaatgatgctctgggctttgg	10	8	4	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr11:101347101C>T	uc001pgk.3	-	6	2100	c.1675G>A	c.(1675-1677)GAC>AAC	p.D559N	TRPC6_uc009ywy.2_Missense_Mutation_p.D443N|TRPC6_uc009ywz.1_Missense_Mutation_p.D504N	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	559	Extracellular (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TCATTTGCGTCAATGATGCTC	0.378													T	101347101	T	T	101347101	3	4	43	1	0	0	0	0	1	0	0	0	16580	826	29	3	1152	3	TRPC6	11	101347101	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	42623841	101347101	33659415	52	2735											
USP28	57646	broad.mit.edu	37	chr11	113677209	113677209	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agaattttaaaaacagagatAccttaatcagccctgcttca	5	9	2	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr11:113677209A>G	uc001poh.2	-	19	2433	c.2400_splice	c.e19+1	p.K800_splice	USP28_uc001pog.2_Intron|USP28_uc010rwy.1_Intron|USP28_uc001poi.2_Intron	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28						cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		AAACAGAGATACCTTAATCAG	0.398													G	113677209	G	G	113677209	5	3	43	1	0	0	0	0	0	0	1	0	17055	405	14	4	859	4	USP28	11	113677209	Splice_Site	SNP	A	TCGA-06-0209-01A-01D-1491-08	12330108	113677209	21329307	53	2736											
LRP6	4040	broad.mit.edu	37	chr12	12311913	12311913	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtcgagatgagtgaaagaCgaggatgtccatcacataat	11	7	1	4			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr12:12311913C>T	uc001rah.3	-	12	2783	c.2641G>A	c.(2641-2643)GTC>ATC	p.V881I	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.V881I	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	881	Extracellular (Potential).|Beta-propeller 3.|LDL-receptor class B 15.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding	p.V881L(1)		lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GAGTGAAAGACGAGGATGTCC	0.537													T	12311913	T	T	12311913	3	4	43	1	0	0	0	0	1	0	0	0	8962	536	19	1	2248	1	LRP6	12	12311913	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08		12311913	121539982	54	2737											
OVCH1	341350	broad.mit.edu	37	chr12	29628100	29628100	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaactgaatattgaagtgatGgtcaacattccacaaagttt	8	6	1	3			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr12:29628100G>A	uc001rix.1	-	14	1494	c.1494C>T	c.(1492-1494)ACC>ACT	p.T498T		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	498	CUB 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TTGAAGTGATGGTCAACATTC	0.299													A	29628100	A	A	29628100	2	1	43	1	0	0	0	0	0	0	0	1	11323	1335	47	3		3	OVCH1	12	29628100	Silent	SNP	G	TCGA-06-0209-01A-01D-1491-08	17316187	29628100	104223795	55	2738											
LRP1	4035	broad.mit.edu	37	chr12	57600507	57600507	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	accggcgacagattgaccggGgtgtcacccacctcaacgtg	12	14	2	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr12:57600507G>T	uc001snd.2	+	76	12308	c.11842G>T	c.(11842-11844)GGT>TGT	p.G3948C		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3948	Extracellular (Potential).|LDL-receptor class B 31.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GATTGACCGGGGTGTCACCCA	0.607													T	57600507	T	T	57600507	3	4	43	1	0	0	0	0	1	0	0	0	8951	1232	43	5	12144	5	LRP1	12	57600507	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	27972407	57600507	76251388	56	2739											
GRIP1	23426	broad.mit.edu	37	chr12	66911726	66911726	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacatgttatcacaactggaCgagatttatttctatcatca	5	9	4	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr12:66911726C>T	uc001stk.2	-	6	774	c.533G>A	c.(532-534)CGT>CAT	p.R178H	GRIP1_uc010sta.1_Missense_Mutation_p.R122H|GRIP1_uc001stl.1_Missense_Mutation_p.R122H|GRIP1_uc001stm.2_Missense_Mutation_p.R178H	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	178	PDZ 2.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CACAACTGGACGAGATTTATT	0.388													T	66911726	T	T	66911726	3	4	43	1	0	0	0	0	1	0	0	0	6787	536	19	1	2773	1	GRIP1	12	66911726	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	9311219	66911726	66940169	57	2740											
METT11D1	64745	broad.mit.edu	37	chr14	21458199	21458199	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gtgtctactgacattaggaaGatggtgccccggccttggag	14	9	1	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr14:21458199G>C	uc001vyn.2	+	1	235	c.38G>C	c.(37-39)AGA>ACA	p.R13T	METT11D1_uc010tlk.1_Missense_Mutation_p.R13T|METT11D1_uc001vym.2_Missense_Mutation_p.R13T|METT11D1_uc001vyo.2_Missense_Mutation_p.R13T|METT11D1_uc001vyp.2_5'UTR|METT11D1_uc001vyq.2_5'UTR	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	13					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		ACATTAGGAAGATGGTGCCCC	0.617													C	21458199	C	C	21458199	3	2	43	1	0	0	0	0	1	0	0	0	9491	942	33	5	40	5	METT11D1	14	21458199	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08		21458199	85891341	58	2741											
METT11D1	64745	broad.mit.edu	37	chr14	21458453	21458453	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtccggtttcctgcagaagaGgcctcatcgccagcaccctg	11	15	1	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr14:21458453G>C	uc001vyn.2	+	2	337	c.140G>C	c.(139-141)AGG>ACG	p.R47T	METT11D1_uc010tlk.1_Missense_Mutation_p.R47T|METT11D1_uc001vym.2_Missense_Mutation_p.R47T|METT11D1_uc001vyo.2_Missense_Mutation_p.R47T|METT11D1_uc001vyp.2_5'UTR|METT11D1_uc001vyq.2_5'UTR	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	47					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CTGCAGAAGAGGCCTCATCGC	0.587											OREG0022561	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	21458453	C	C	21458453	3	2	43	1	0	0	0	0	1	0	0	0	9491	1000	35	5	146	5	METT11D1	14	21458453	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	254	21458453	85891087	59	2742											
GNG2	54331	broad.mit.edu	37	chr14	52433353	52433353	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccctcctgacccctgttcCggcttcagaaaacccgttta	6	18	1	2	rs139067662	by1000genomes	TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr14:52433353C>T	uc001wzi.2	+	4	693	c.164C>T	c.(163-165)CCG>CTG	p.P55L	GNG2_uc001wzh.2_RNA|GNG2_uc010aoc.1_RNA|GNG2_uc001wzj.2_RNA|GNG2_uc001wzk.2_Missense_Mutation_p.P55L	NM_053064	NP_444292	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein),	55					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity				0	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	ACCCCTGTTCCGGCTTCAGAA	0.527													T	52433353	T	T	52433353	3	4	43	1	0	0	0	0	1	0	0	0	6527	652	23	2	170	2	GNG2	14	52433353	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	30974900	52433353	54916187	60	2743											
LTBP2	4053	broad.mit.edu	37	chr14	74970199	74970199	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggtgctgttcatgcagcGctgctggctgaggtccaggg	17	10	1	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr14:74970199G>A	uc001xqa.2	-	32	5080	c.4693C>T	c.(4693-4695)CGC>TGC	p.R1565C		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1565	EGF-like 18; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TTCATGCAGCGCTGCTGGCTG	0.672													A	74970199	A	A	74970199	3	1	43	1	0	0	0	0	1	0	0	0	9074	1087	38	1	792	1	LTBP2	14	74970199	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	22536846	74970199	32379341	61	2744											
PSMC1	5700	broad.mit.edu	37	chr14	90736610	90736610	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agaagcgcatctttcagattCacacaagcaggatgacgctg	10	10	3	3			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr14:90736610C>T	uc001xyf.2	+	10	1150	c.1102C>T	c.(1102-1104)CAC>TAC	p.H368Y	PSMC1_uc001xyg.2_Missense_Mutation_p.H295Y|PSMC1_uc001xyh.2_Missense_Mutation_p.H295Y	NM_002802	NP_002793	P62191	PRS4_HUMAN	proteasome 26S ATPase subunit 1	368					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0		all_cancers(154;0.142)		COAD - Colon adenocarcinoma(157;0.21)		CTTTCAGATTCACACAAGCAG	0.502													T	90736610	T	T	90736610	3	4	43	1	0	0	0	0	1	0	0	0	12685	826	29	3	1140	3	PSMC1	14	90736610	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	15766411	90736610	16612930	62	2745											
SERPINA3	12	broad.mit.edu	37	chr14	95080911	95080911	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accaagaccgagggacacacGtggacctcggattagcctcc	11	14	0	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr14:95080911G>A	uc001ydp.2	+	2	212	c.133G>A	c.(133-135)GTG>ATG	p.V45M	SERPINA3_uc001ydo.3_Missense_Mutation_p.V70M|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.V45M|SERPINA3_uc001yds.2_Missense_Mutation_p.V45M|SERPINA3_uc010avg.2_Missense_Mutation_p.V45M	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	45					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity	p.V45M(1)		ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		AGGGACACACGTGGACCTCGG	0.572													A	95080911	A	A	95080911	3	1	43	1	0	0	0	0	1	0	0	0	14090	1145	40	1	135	1	SERPINA3	14	95080911	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	4344301	95080911	12268629	63	2746											
BCL11B	64919	broad.mit.edu	37	chr14	99642475	99642475	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtgctgcagcaggaaccacGcgctgttgaagggctgcttg	15	11	0	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr14:99642475G>A	uc001yga.2	-	4	965	c.698C>T	c.(697-699)GCG>GTG	p.A233V	BCL11B_uc001ygb.2_Missense_Mutation_p.A162V	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	233	C2H2-type 1.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CAGGAACCACGCGCTGTTGAA	0.617			T	TLX3	T-ALL								A	99642475	A	A	99642475	3	1	43	1	0	0	0	0	1	0	0	0	1364	1087	38	1	1990	1	BCL11B	14	99642475	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	4561564	99642475	7707065	64	2747											
HDC	3067	broad.mit.edu	37	chr15	50535347	50535347	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagatggtattacctttagaCgaaaaaccaccaggccaagg	9	9	0	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr15:50535347C>T	uc001zxz.2	-	11	1341	c.1235G>A	c.(1234-1236)CGT>CAT	p.R412H	HDC_uc001zxy.2_Missense_Mutation_p.R155H|HDC_uc010uff.1_Missense_Mutation_p.R379H	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	412					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TACCTTTAGACGAAAAACCAC	0.483													T	50535347	T	T	50535347	3	4	43	1	0	0	0	0	1	0	0	0	7015	536	19	1	761	1	HDC	15	50535347	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08		50535347	51996045	65	2748											
CP110	9738	broad.mit.edu	37	chr16	19547973	19547973	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaaagtggacatacctataCgaactggccatcccactgtt	8	12	0	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr16:19547973C>T	uc002dgl.3	+	4	1229	c.982C>T	c.(982-984)CGA>TGA	p.R328*	CP110_uc002dgk.3_Nonsense_Mutation_p.R328*			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	328					centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						CATACCTATACGAACTGGCCA	0.373													T	19547973	T	T	19547973	4	4	43	1	0	0	0	0	0	1	0	0	3788	528	19	1	992	1	CP110	16	19547973	Nonsense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08		19547973	70806780	66	2749											
CACNG3	10368	broad.mit.edu	37	chr16	24358110	24358110	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccctgaagatgctgactaCgaacaggacacagccgaata	9	11	0	3			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr16:24358110C>T	uc002dmf.2	+	2	1467	c.267C>T	c.(265-267)TAC>TAT	p.Y89Y		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	89					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		ATGCTGACTACGAACAGGACA	0.562													T	24358110	T	T	24358110	2	4	43	1	0	0	0	0	0	0	0	1	2558	547	19	1		1	CACNG3	16	24358110	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08	4810137	24358110	65996643	67	2750											
OGFOD1	55239	broad.mit.edu	37	chr16	56510097	56510097	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaacaggtttctgggactttTcattcatctattatgaatga	8	6	4	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr16:56510097T>C	uc002ejb.2	+	13	1710	c.1609T>C	c.(1609-1611)TCA>CCA	p.S537P	OGFOD1_uc002ejc.2_Missense_Mutation_p.S397P	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	537							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	CTGGGACTTTTCATTCATCTA	0.418													C	56510097	C	C	56510097	3	2	43	1	0	0	0	0	1	0	0	0	10841	1783	62	4	1659	4	OGFOD1	16	56510097	Missense_Mutation	SNP	T	TCGA-06-0209-01A-01D-1491-08	32151987	56510097	33844656	68	2751											
MYH2	4620	broad.mit.edu	37	chr17	10428349	10428349	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcaactcaagctggatgcGcaggatctttccctcttcat	8	12	5	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr17:10428349G>A	uc010coi.2	-	34	4824	c.4696C>T	c.(4696-4698)CGC>TGC	p.R1566C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1566C|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1566	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AGCTGGATGCGCAGGATCTTT	0.408													A	10428349	A	A	10428349	3	1	43	1	0	0	0	0	1	0	0	0	10035	1087	38	1	1157	1	MYH2	17	10428349	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08		10428349	70766861	69	2752											
XYLT2	64132	broad.mit.edu	37	chr17	48433460	48433460	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcagtccttcttccacacGgtgctggagaacagcctggc	11	13	1	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr17:48433460G>A	uc002iqo.2	+	7	1429	c.1320G>A	c.(1318-1320)ACG>ACA	p.T440T	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	440	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					TCTTCCACACGGTGCTGGAGA	0.617													A	48433460	A	A	48433460	2	1	43	1	0	0	0	0	0	0	0	1	17461	1103	39	2		2	XYLT2	17	48433460	Silent	SNP	G	TCGA-06-0209-01A-01D-1491-08	38005111	48433460	32761750	70	2753											
VEZF1	7716	broad.mit.edu	37	chr17	56060219	56060219	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatgggagagcttgtgtcgaTtgagatggtacacatctcgg	14	6	1	2			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr17:56060219T>C	uc002ivf.1	-	2	712	c.569A>G	c.(568-570)AAT>AGT	p.N190S	VEZF1_uc010dcn.1_Missense_Mutation_p.N34S	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	190	C2H2-type 2.				cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CTTGTGTCGATTGAGATGGTA	0.483													C	56060219	C	C	56060219	3	2	43	1	0	0	0	0	1	0	0	0	17152	1493	52	4	1016	4	VEZF1	17	56060219	Missense_Mutation	SNP	T	TCGA-06-0209-01A-01D-1491-08	7626759	56060219	25134991	71	2754											
QRICH2	84074	broad.mit.edu	37	chr17	74276228	74276228	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcactgggtccagctccaggCggtccagctgtggcggggaa	16	12	1	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr17:74276228C>T	uc002jrd.1	-	12	4316	c.4136G>A	c.(4135-4137)CGC>CAC	p.R1379H	QRICH2_uc010wsz.1_Intron|QRICH2_uc010dgw.1_Missense_Mutation_p.R223H	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1379							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CAGCTCCAGGCGGTCCAGCTG	0.657													T	74276228	T	T	74276228	3	4	43	1	0	0	0	0	1	0	0	0	12880	768	27	1	887	1	QRICH2	17	74276228	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	18216009	74276228	6918982	72	2755											
DSG3	1830	broad.mit.edu	37	chr18	29038537	29038537	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttaacataacagctatagtcGaccgggaggaaactccaagc	9	10	0	0	rs137884016	byFrequency	TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr18:29038537G>A	uc002kws.2	+	4	455	c.346G>A	c.(346-348)GAC>AAC	p.D116N		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	116	Extracellular (Potential).|Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGCTATAGTCGACCGGGAGGA	0.443													A	29038537	A	A	29038537	3	1	43	1	0	0	0	0	1	0	0	0	4778	1058	37	2	360	2	DSG3	18	29038537	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08		29038537	49038711	73	2756											
ALPK2	115701	broad.mit.edu	37	chr18	56203942	56203942	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcctcttgtgcagcagatgtCgtaggcaaactttgttggaa	11	8	1	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr18:56203942C>T	uc002lhj.3	-	5	3691	c.3477G>A	c.(3475-3477)ACG>ACA	p.T1159T	ALPK2_uc002lhk.1_Silent_p.T490T	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1159							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CAGCAGATGTCGTAGGCAAAC	0.567													T	56203942	T	T	56203942	2	4	43	1	0	0	0	0	0	0	0	1	545	871	31	2		2	ALPK2	18	56203942	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08	27165405	56203942	21873306	74	2757											
MAP2K7	5609	broad.mit.edu	37	chr19	7975352	7975352	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcagcaaatgcggcgctcCgggaacaaggaggagaacaa	15	9	0	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr19:7975352C>T	uc002mit.2	+	5	527	c.462C>T	c.(460-462)TCC>TCT	p.S154S	MAP2K7_uc002miv.2_Silent_p.S154S|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Silent_p.S154S|MAP2K7_uc010dvv.2_Silent_p.S29S	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	154	Protein kinase.				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	TGCGGCGCTCCGGGAACAAGG	0.632													T	7975352	T	T	7975352	2	4	43	1	0	0	0	0	0	0	0	1	9242	639	23	2		2	MAP2K7	19	7975352	Silent	SNP	C	TCGA-06-0209-01A-01D-1491-08		7975352	51153631	75	2758											
MUC16	94025	broad.mit.edu	37	chr19	9047027	9047027	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcaggtgagatagttgtcGttgaaacagctgaactggct	12	6	1	3	rs111231164		TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr19:9047027G>A	uc002mkp.2	-	5	34808	c.34604C>T	c.(34603-34605)ACG>ATG	p.T11535M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11537	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATAGTTGTCGTTGAAACAGC	0.512													A	9047027	A	A	9047027	3	1	43	1	0	0	0	0	1	0	0	0	9973	1145	40	1	9239	1	MUC16	19	9047027	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	1071675	9047027	50081956	76	2759											
MRPS12	6183	broad.mit.edu	37	chr19	39423173	39423173	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcgcaagtgctgtcgagtgCggctcagcactggccgcgag	15	12	1	0	rs140018981	by1000genomes	TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr19:39423173C>T	uc002okc.2	+	3	560	c.250C>T	c.(250-252)CGG>TGG	p.R84W	SARS2_uc002ojz.2_5'Flank|SARS2_uc010xup.1_5'Flank|SARS2_uc002oka.2_5'Flank|SARS2_uc002okb.2_5'Flank|SARS2_uc010xuq.1_Intron|SARS2_uc010xur.1_5'Flank|SARS2_uc010xus.1_5'Flank|MRPS12_uc002okd.2_Missense_Mutation_p.R84W|MRPS12_uc002oke.2_Missense_Mutation_p.R84W	NM_033362	NP_203526	O15235	RT12_HUMAN	mitochondrial ribosomal protein S12 precursor	84					translation	mitochondrial ribosome|small ribosomal subunit	protein binding|structural constituent of ribosome				0	all_cancers(60;8.37e-07)|all_lung(34;3.71e-07)|Lung NSC(34;4.17e-07)|all_epithelial(25;1.13e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CTGTCGAGTGCGGCTCAGCAC	0.662													T	39423173	T	T	39423173	3	4	43	1	0	0	0	0	1	0	0	0	9823	759	27	1	256	1	MRPS12	19	39423173	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	30376146	39423173	19705810	77	2760											
ZNF546	339327	broad.mit.edu	37	chr19	40520966	40520969	+	Frame_Shift_Del	DEL	ACTC	-	-													ttagtcgtcgctataatcttActcaacattttaaaattcat							TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr19:40520966_40520969delACTC	uc002oms.2	+	7	2045_2048	c.1789_1792delACTC	c.(1789-1794)ACTCAAfs	p.T597fs	ZNF546_uc002omt.2_Frame_Shift_Del_p.T571fs	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	597_598	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CTATAATCTTACTCAACATTTTAA	0.353													-	40520969	-	-	40520966	7	5	43	1	0	1	0	1	0	0	0	0	17975	391	14	0	1807	0	ZNF546	19	40520966	Frame_Shift_Del	DEL	ACTC	TCGA-06-0209-01A-01D-1491-08	1097793	40520966	18608017	78	2761											
PSG5	5673	broad.mit.edu	37	chr19	43689122	43689122	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tttgaccgtctactacatatGatgtaatgtaatggtagagg	10	5	1	3			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr19:43689122G>A	uc002ovu.2	-	2	373	c.242C>T	c.(241-243)TCA>TTA	p.S81L	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.S9L|PSG5_uc002ovx.2_Missense_Mutation_p.S81L|PSG5_uc002ovv.2_Missense_Mutation_p.S81L|PSG5_uc002ovw.2_Missense_Mutation_p.S81L	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	81	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				TACTACATATGATGTAATGTA	0.433													A	43689122	A	A	43689122	3	1	43	1	0	0	0	0	1	0	0	0	12658	1294	45	3	781	3	PSG5	19	43689122	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08	3168156	43689122	15439861	79	2762											
XRCC1	7515	broad.mit.edu	37	chr19	44055781	44055781	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcacccactccttacgcaCgatgcggcctcccaggccta	8	19	0	0	rs2271980		TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr19:44055781C>T	uc002owt.2	-	10	1261	c.1141G>A	c.(1141-1143)GTG>ATG	p.V381M	XRCC1_uc010xwp.1_Missense_Mutation_p.V350M	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	381	BRCT 1.				base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TCCTTACGCACGATGCGGCCT	0.622								Other_BER_factors					T	44055781	T	T	44055781	3	4	43	1	0	0	0	0	1	0	0	0	17449	536	19	1	792	1	XRCC1	19	44055781	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	366659	44055781	15073202	80	2763											
BPIL1	80341	broad.mit.edu	37	chr20	31606076	31606076	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcatgaaggcctcaaccccGtgggtcctgagtcccagatc	10	14	2	3	rs147688509	byFrequency	TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr20:31606076G>A	uc002wyj.2	+	8	783	c.589G>A	c.(589-591)GTG>ATG	p.V197M		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	197						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						CCTCAACCCCGTGGGTCCTGA	0.483													A	31606076	A	A	31606076	3	1	43	1	0	0	0	0	1	0	0	0	1491	1145	40	1	615	1	BPIL1	20	31606076	Missense_Mutation	SNP	G	TCGA-06-0209-01A-01D-1491-08		31606076	31419444	81	2764											
PIGU	128869	broad.mit.edu	37	chr20	33169458	33169460	+	In_Frame_Del	DEL	GAA	-	-													acagcgatctggataaacatGaagaagatggggtgctccct							TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr20:33169458_33169460delGAA	uc002xas.2	-	10	1143_1145	c.943_945delTTC	c.(943-945)TTCdel	p.F315del	PIGU_uc010zul.1_In_Frame_Del_p.F315del|PIGU_uc002xat.2_In_Frame_Del_p.F295del	NM_080476	NP_536724	Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	315	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane					0						GGATAAACATGAAGAAGATGGGG	0.562													-	33169460	-	-	33169458	7	5	43	1	0	1	0	1	0	0	0	0	11900	1281	45	0	374	0	PIGU	20	33169458	In_Frame_Del	DEL	GAA	TCGA-06-0209-01A-01D-1491-08	1563382	33169458	29856062	82	2765											
RBM38	55544	broad.mit.edu	37	chr20	55968365	55968365	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggggtgcagcagctgcaccCcaccttgatccagcggactt	12	14	0	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr20:55968365C>G	uc010zzj.1	+	3	567	c.392C>G	c.(391-393)CCC>CGC	p.P131R	RBM38_uc010zzk.1_Intron	NM_017495	NP_059965	Q9H0Z9	RBM38_HUMAN	RNA-binding region containing protein 1 isoform	131					3'-UTR-mediated mRNA stabilization|cell cycle|cell cycle arrest|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mRNA processing|negative regulation of cell proliferation|regulation of RNA splicing|RNA splicing	cytosol|cytosol|nucleus|nucleus	mRNA 3'-UTR binding|mRNA binding|nucleotide binding|RNA binding				0	Lung NSC(12;0.00242)|all_lung(29;0.00767)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.55e-12)|Epithelial(14;9.49e-09)|all cancers(14;5.01e-08)			CAGCTGCACCCCACCTTGATC	0.597													G	55968365	G	G	55968365	3	3	43	1	0	0	0	0	1	0	0	0	13132	623	22	5	161	5	RBM38	20	55968365	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	22798907	55968365	7057155	83	2766											
KRTAP19-4	337971	broad.mit.edu	37	chr21	31869311	31869311	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atatccgttgcctccaaagcCacagccataacccagtctgc	6	16	1	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chr21:31869311C>T	uc011acz.1	-	1	118	c.118G>A	c.(118-120)GGC>AGC	p.G40S		NM_181610	NP_853641	Q3LI73	KR194_HUMAN	keratin associated protein 19-4	40						intermediate filament				ovary(2)	2						CCTCCAAAGCCACAGCCATAA	0.527													T	31869311	T	T	31869311	3	4	43	1	0	0	0	0	1	0	0	0	8531	594	21	3	139	3	KRTAP19-4	21	31869311	Missense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08		31869311	16260584	84	2767											
KIAA2022	340533	broad.mit.edu	37	chrX	73963609	73963609	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctttcactaataaaagtctcGaagtaaccccaatcctgatt	4	11	2	1			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chrX:73963609G>A	uc004eby.2	-	3	1400	c.783C>T	c.(781-783)TTC>TTT	p.F261F		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	261					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TAAAAGTCTCGAAGTAACCCC	0.393													A	73963609	A	A	73963609	2	1	43	1	0	0	0	0	0	0	0	1	8269	1049	37	2		2	KIAA2022	23	73963609	Silent	SNP	G	TCGA-06-0209-01A-01D-1491-08		73963609	81306951	85	2768											
NRK	203447	broad.mit.edu	37	chrX	105152945	105152945	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaggctcaggcacctcaaCgactacaaggggcagctcgg	14	13	2	0			TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chrX:105152945C>T	uc004emd.2	+	13	1615	c.1312C>T	c.(1312-1314)CGA>TGA	p.R438*	NRK_uc010npc.1_Nonsense_Mutation_p.R106*	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	438	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GGCACCTCAACGACTACAAGG	0.557										HNSCC(51;0.14)			T	105152945	T	T	105152945	4	4	43	1	0	0	0	0	0	1	0	0	10655	528	19	1	1362	1	NRK	23	105152945	Nonsense_Mutation	SNP	C	TCGA-06-0209-01A-01D-1491-08	31189336	105152945	50117615	86	2769											
SH2D1A	4068	broad.mit.edu	37	chrX	123504148	123504149	+	Frame_Shift_Ins	INS	-	A	A													ttgagaagaagtcctcagctINSagaagtacacaaggtactac							TCGA-06-0209-01A-01D-1491-08	TCGA-06-0209-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	b4a7de67-14b6-4b8c-abbe-9eaa990d905e	dc506a4e-4b70-49ce-a3f8-beb81638a762	g.chrX:123504148_123504149insA	uc004euf.3	+	3	669_670	c.324_325insA	c.(322-327)GCTAGAfs	p.A108fs	SH2D1A_uc004euh.3_Frame_Shift_Ins_p.A108fs|SH2D1A_uc004eug.3_RNA|SH2D1A_uc010nqw.2_RNA|SH2D1A_uc004eui.3_RNA|SH2D1A_uc010nqx.2_RNA	NM_002351	NP_002342	O60880	SH21A_HUMAN	SH2 domain protein 1A isoform 1	108_109					cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity				0						AGTCCTCAGCTAGAAGTACACA	0.371									X-linked_Lymphoproliferative_syndrome				A	123504149	A	A	123504148	7	5	43	1	0	1	1	0	0	0	0	0	14230	1509	53	0	334	0	SH2D1A	23	123504148	Frame_Shift_Ins	INS	-	TCGA-06-0209-01A-01D-1491-08	18351203	123504148	31766412	87	2770											
COL8A2	1296	broad.mit.edu	37	chr1	36565672	36565672	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	caggtactggcctttgccctCacggaagggcggtcccacag	13	14	1	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:36565672C>T	uc001bzv.1	-	1	179	c.172G>A	c.(172-174)GAG>AAG	p.E58K	COL8A2_uc001bzw.1_Intron	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	58	Nonhelical region (NC2).				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCTTTGCCCTCACGGAAGGGC	0.662											OREG0013361	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	36565672	T	T	36565672	3	4	44	1	0	0	0	0	1	0	0	0	3706	835	29	3	1947	3	COL8A2	1	36565672	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08		36565672	212684949	1	2771											
CYP4A11	1579	broad.mit.edu	37	chr1	47406941	47406941	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcccgaagagccagtgggaGggagggcacgggaactgctg	19	9	0	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:47406941G>A	uc001cqp.3	-	1	216	c.165C>T	c.(163-165)CCC>CCT	p.P55P	CYP4A11_uc001cqq.2_Silent_p.P55P|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	55					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GCCAGTGGGAGGGAGGGCACG	0.597													A	47406941	A	A	47406941	2	1	44	1	0	0	0	0	0	0	0	1	4183	987	35	3		3	CYP4A11	1	47406941	Silent	SNP	G	TCGA-06-0213-01A-01D-1491-08	10841269	47406941	201843680	2	2772											
LHX8	431707	broad.mit.edu	37	chr1	75614357	75614357	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggacaggcttgagcagacGtgtgatacaggtgattactt	13	6	0	4			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:75614357G>A	uc001dgo.2	+	8	1464	c.800G>A	c.(799-801)CGT>CAT	p.R267H	LHX8_uc001dgq.2_Missense_Mutation_p.R206H	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	267	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TTGAGCAGACGTGTGATACAG	0.269													A	75614357	A	A	75614357	3	1	44	1	0	0	0	0	1	0	0	0	8776	1145	40	1	826	1	LHX8	1	75614357	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	28207416	75614357	173636264	3	2773											
MCOLN2	255231	broad.mit.edu	37	chr1	85422200	85422200	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcttacagacttttaagCcaattctattgtcttcattt	5	9	3	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:85422200C>T	uc001dkm.2	-	4	720	c.479G>A	c.(478-480)GGC>GAC	p.G160D	MCOLN2_uc001dkn.2_RNA	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	160						integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		GACTTTTAAGCCAATTCTATT	0.373													T	85422200	T	T	85422200	3	4	44	1	0	0	0	0	1	0	0	0	9396	739	26	3	1265	3	MCOLN2	1	85422200	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	9807843	85422200	163828421	4	2774											
COL24A1	255631	broad.mit.edu	37	chr1	86289377	86289379	+	In_Frame_Del	DEL	TTG	-	-													tcaaaacatactgggggtccTtgttgtccagtggcacctct							TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:86289377_86289379delTTG	uc001dlj.2	-	44	3766_3768	c.3724_3726delCAA	c.(3724-3726)CAAdel	p.Q1242del	COL24A1_uc001dli.2_In_Frame_Del_p.Q378del|COL24A1_uc010osd.1_In_Frame_Del_p.Q542del|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1242	Collagen-like 13.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTGGGGGTCCTTGTTGTCCAGTG	0.34													-	86289379	-	-	86289377	7	5	44	1	0	1	0	1	0	0	0	0	3683	1606	56	0	1486	0	COL24A1	1	86289377	In_Frame_Del	DEL	TTG	TCGA-06-0213-01A-01D-1491-08	867177	86289377	162961244	5	2775											
ACP6	51205	broad.mit.edu	37	chr1	147131584	147131584	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttcttcctcagtctctctcCcaaggcaaacatttgctgca	6	14	4	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:147131584C>T	uc001epr.2	-	3	870	c.406G>A	c.(406-408)GGA>AGA	p.G136R	ACP6_uc009wjj.1_Missense_Mutation_p.G93R	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	136					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					AGTCTCTCTCCCAAGGCAAAC	0.483													T	147131584	T	T	147131584	3	4	44	1	0	0	0	0	1	0	0	0	165	632	22	3	912	3	ACP6	1	147131584	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	60842207	147131584	102119037	6	2776											
FLG	2312	broad.mit.edu	37	chr1	152275520	152275520	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	actagaactgtgaggactgcCacgtgactgtattcctgagt	11	9	0	4			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:152275520C>A	uc001ezu.1	-	3	11878	c.11842G>T	c.(11842-11844)GGC>TGC	p.G3948C		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3948	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGGACTGCCACGTGACTGT	0.438									Ichthyosis				A	152275520	A	A	152275520	3	1	44	1	0	0	0	0	1	0	0	0	5922	594	21	5	347	5	FLG	1	152275520	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	5143936	152275520	96975101	7	2777											
SH2D1B	117157	broad.mit.edu	37	chr1	162368720	162368720	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagagattttaccacaaatGtttccaactctaatttcaat	4	8	2	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:162368720G>A	uc001gbz.1	-	3	478	c.356C>T	c.(355-357)ACA>ATA	p.T119I	SH2D1B_uc001gca.1_Intron	NM_053282	NP_444512	O14796	SH21B_HUMAN	SH2 domain containing 1B	119										pancreas(1)	1	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TACCACAAATGTTTCCAACTC	0.393													A	162368720	A	A	162368720	3	1	44	1	0	0	0	0	1	0	0	0	14231	1377	48	3	50	3	SH2D1B	1	162368720	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	10093200	162368720	86881901	8	2778											
MYOC	4653	broad.mit.edu	37	chr1	171621317	171621317	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agaactgacttgtctcggagGaggttgctgtaggcagtctc	14	8	2	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:171621317G>T	uc001ghu.2	-	1	457	c.435C>A	c.(433-435)CTC>CTA	p.L145L	MYOC_uc010pmk.1_Silent_p.L87L	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	145	Potential.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGTCTCGGAGGAGGTTGCTGT	0.577													T	171621317	T	T	171621317	2	4	44	1	0	0	0	0	0	0	0	1	10086	1161	41	5		5	MYOC	1	171621317	Silent	SNP	G	TCGA-06-0213-01A-01D-1491-08	9252597	171621317	77629304	9	2779											
RBBP5	5929	broad.mit.edu	37	chr1	205065948	205065948	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggtttggactgcatccgGtggggggccgtaaggatttt	18	6	0	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:205065948G>A	uc001hbu.1	-	12	1388	c.1258C>T	c.(1258-1260)CCG>TCG	p.P420S	RBBP5_uc010prd.1_Missense_Mutation_p.P455S|RBBP5_uc001hbv.1_Missense_Mutation_p.P420S|RBBP5_uc010pre.1_Missense_Mutation_p.P287S	NM_005057	NP_005048	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	420					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			lung(1)	1	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			ACTGCATCCGGTGGGGGGCCG	0.498													A	205065948	A	A	205065948	3	1	44	1	0	0	0	0	1	0	0	0	13102	1261	44	3	370	3	RBBP5	1	205065948	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	33444631	205065948	44184673	10	2780											
SYT14	255928	broad.mit.edu	37	chr1	210267700	210267700	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaatgagaagaacaccccCgctggatgaattgcagccac	11	11	0	4	rs77686387	by1000genomes	TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr1:210267700C>T	uc009xcv.2	+	5	548	c.476C>T	c.(475-477)CCG>CTG	p.P159L	SYT14_uc001hhs.3_Missense_Mutation_p.P204L|SYT14_uc001hht.3_Missense_Mutation_p.P159L|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Missense_Mutation_p.P204L|SYT14_uc010pso.1_Missense_Mutation_p.P121L	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	159	Cytoplasmic (Potential).					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		AGAACACCCCCGCTGGATGAA	0.428													T	210267700	T	T	210267700	3	4	44	1	0	0	0	0	1	0	0	0	15467	652	23	2	633	2	SYT14	1	210267700	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	5201752	210267700	38982921	11	2781											
TTC15	51112	broad.mit.edu	37	chr2	3392024	3392024	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccagcctcagcacgttcttCggagacacggccgccagcca	10	18	2	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr2:3392024C>T	uc002qxm.1	+	2	836	c.630C>T	c.(628-630)TTC>TTT	p.F210F	TTC15_uc002qxn.1_Silent_p.F210F|TTC15_uc010ewm.1_Silent_p.F210F|TTC15_uc002qxl.1_Silent_p.F210F	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	210							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		GCACGTTCTTCGGAGACACGG	0.587													T	3392024	T	T	3392024	2	4	44	1	0	0	0	0	0	0	0	1	16679	883	31	2		2	TTC15	2	3392024	Silent	SNP	C	TCGA-06-0213-01A-01D-1491-08		3392024	239807349	12	2782											
GREB1	9687	broad.mit.edu	37	chr2	11706613	11706613	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacccctcctagggttttgCcaggccgggaaggacctgcg	13	15	0	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr2:11706613C>T	uc002rbk.1	+	4	585	c.285C>T	c.(283-285)TGC>TGT	p.C95C	GREB1_uc002rbl.2_Silent_p.C95C|GREB1_uc002rbm.2_5'UTR|GREB1_uc002rbn.1_Silent_p.C95C	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	95						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TAGGGTTTTGCCAGGCCGGGA	0.642													T	11706613	T	T	11706613	2	4	44	1	0	0	0	0	0	0	0	1	6760	747	26	3		3	GREB1	2	11706613	Silent	SNP	C	TCGA-06-0213-01A-01D-1491-08	8314589	11706613	231492760	13	2783											
BUB1	699	broad.mit.edu	37	chr2	111408233	111408233	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtcagtgtctgtgagtctgCaagcctcaacgcccaactct	9	14	5	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr2:111408233C>T	uc002tgc.2	-	18	2205	c.2093G>A	c.(2092-2094)TGC>TAC	p.C698Y	BUB1_uc010yxh.1_Missense_Mutation_p.C678Y|BUB1_uc010fkb.2_Missense_Mutation_p.C698Y	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	698					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TGTGAGTCTGCAAGCCTCAAC	0.532													T	111408233	T	T	111408233	3	4	44	1	0	0	0	0	1	0	0	0	1570	710	25	3	1196	3	BUB1	2	111408233	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	99701620	111408233	131791140	14	2784											
SCN9A	6335	broad.mit.edu	37	chr2	167055444	167055444	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cattttgccttaagcggtaaCgtctataagcacgctgaatg	9	9	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr2:167055444C>G	uc010fpl.2	-	27	6013	c.5672G>C	c.(5671-5673)CGT>CCT	p.R1891P	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1902	IQ.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TAAGCGGTAACGTCTATAAGC	0.363													G	167055444	G	G	167055444	3	3	44	1	0	0	0	0	1	0	0	0	13925	536	19	5	265	5	SCN9A	2	167055444	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	55647211	167055444	76143929	15	2785											
COL3A1	1281	broad.mit.edu	37	chr2	189868848	189868848	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaccaggagagaagggatcGcctggtgcccagggcccacc	14	14	0	1	rs113870310		TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr2:189868848G>A	uc002uqj.1	+	39	2919	c.2802G>A	c.(2800-2802)TCG>TCA	p.S934S		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	934	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.S934S(1)		central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AGAAGGGATCGCCTGGTGCCC	0.488													A	189868848	A	A	189868848	2	1	44	1	0	0	0	0	0	0	0	1	3688	1074	38	1		1	COL3A1	2	189868848	Silent	SNP	G	TCGA-06-0213-01A-01D-1491-08	22813404	189868848	53330525	16	2786											
NBEAL1	65065	broad.mit.edu	37	chr2	204037528	204037528	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtatttcgagatctttccaAaccaattggggtagttaatg	9	6	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr2:204037528A>G	uc002uzt.3	+	40	6521	c.6188A>G	c.(6187-6189)AAA>AGA	p.K2063R	NBEAL1_uc002uzs.3_Missense_Mutation_p.K773R	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2063	BEACH.						binding			ovary(1)|skin(1)	2						GATCTTTCCAAACCAATTGGG	0.328													G	204037528	G	G	204037528	3	3	44	1	0	0	0	0	1	0	0	0	10188	14	1	4	6342	4	NBEAL1	2	204037528	Missense_Mutation	SNP	A	TCGA-06-0213-01A-01D-1491-08	14168680	204037528	39161845	17	2787											
FGD5	152273	broad.mit.edu	37	chr3	14960268	14960268	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttggttttccaggtcagccGccctgtgatggagaaagtgc	14	9	1	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr3:14960268G>A	uc003bzc.2	+	13	3607	c.3497G>A	c.(3496-3498)CGC>CAC	p.R1166H	FGD5_uc011avk.1_Missense_Mutation_p.R1166H|FGD5_uc003bzd.2_Missense_Mutation_p.R244H	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1166	PH 1.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CAGGTCAGCCGCCCTGTGATG	0.602													A	14960268	A	A	14960268	3	1	44	1	0	0	0	0	1	0	0	0	5836	1087	38	1	3547	1	FGD5	3	14960268	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08		14960268	183062162	18	2788											
OR5AC2	81050	broad.mit.edu	37	chr3	97806681	97806681	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcataatctcttatactcGtgtgctctttgatattctga	5	8	4	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr3:97806681G>A	uc011bgs.1	+	1	665	c.665G>A	c.(664-666)CGT>CAT	p.R222H		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTTATACTCGTGTGCTCTTT	0.373													A	97806681	A	A	97806681	3	1	44	1	0	0	0	0	1	0	0	0	11141	1145	40	1	667	1	OR5AC2	3	97806681	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	82846413	97806681	100215749	19	2789											
DTX3L	151636	broad.mit.edu	37	chr3	122289489	122289489	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacttggaatgatattcaccAcaaaacatcccggtttggag	8	10	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr3:122289489A>G	uc003efk.2	+	4	2212	c.2123A>G	c.(2122-2124)CAC>CGC	p.H708R	DTX3L_uc010hrj.2_Missense_Mutation_p.H196R	NM_138287	NP_612144	Q8TDB6	DTX3L_HUMAN	deltex 3-like	708					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)	4				GBM - Glioblastoma multiforme(114;0.0459)		GATATTCACCACAAAACATCC	0.423													G	122289489	G	G	122289489	3	3	44	1	0	0	0	0	1	0	0	0	4796	159	6	4	2137	4	DTX3L	3	122289489	Missense_Mutation	SNP	A	TCGA-06-0213-01A-01D-1491-08	24482808	122289489	75732941	20	2790											
PDGFRA	5156	broad.mit.edu	37	chr4	55156661	55156661	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgacagtggctacatcattcCtctgcctgacattgaccctg	8	13	2	3			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr4:55156661C>T	uc003han.3	+	22	3393	c.3062C>T	c.(3061-3063)CCT>CTT	p.P1021L	PDGFRA_uc003haa.2_Missense_Mutation_p.P781L	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	1021	Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TACATCATTCCTCTGCCTGAC	0.562			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			T	55156661	T	T	55156661	3	4	44	1	0	0	0	0	1	0	0	0	11661	681	24	3	3144	3	PDGFRA	4	55156661	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08		55156661	135997615	21	2791											
FSTL5	56884	broad.mit.edu	37	chr4	162697175	162697175	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatatttttgattttgtaaaTctaatagcatatttttcatc	3	4	2	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr4:162697175T>C	uc003iqh.2	-	5	897	c.461A>G	c.(460-462)GAT>GGT	p.D154G	FSTL5_uc003iqi.2_Missense_Mutation_p.D153G|FSTL5_uc010iqv.2_Missense_Mutation_p.D153G	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	154						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATTTTGTAAATCTAATAGCAT	0.279													C	162697175	C	C	162697175	3	2	44	1	0	0	0	0	1	0	0	0	6080	1435	50	4	2130	4	FSTL5	4	162697175	Missense_Mutation	SNP	T	TCGA-06-0213-01A-01D-1491-08	107540514	162697175	28457101	22	2792											
CHSY3	337876	broad.mit.edu	37	chr5	129243856	129243856	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcctggggaatattgaagagCttggaaagctgggactggag	17	5	0	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr5:129243856C>G	uc003kvd.2	+	2	889	c.889C>G	c.(889-891)CTT>GTT	p.L297V		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	297	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		TATTGAAGAGCTTGGAAAGCT	0.473													G	129243856	G	G	129243856	3	3	44	1	0	0	0	0	1	0	0	0	3413	797	28	5	895	5	CHSY3	5	129243856	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08		129243856	51671404	23	2793											
SLIT3	6586	broad.mit.edu	37	chr5	168175347	168175347	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgcctctggggagggcgcGgagccccttgttgctgcatc	15	13	1	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr5:168175347G>A	uc003mab.2	-	20	2650	c.2230C>T	c.(2230-2232)CGC>TGC	p.R744C	SLIT3_uc010jjg.2_Missense_Mutation_p.R744C	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	744	LRRNT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGAGGGCGCGGAGCCCCTTG	0.632													A	168175347	A	A	168175347	3	1	44	1	0	0	0	0	1	0	0	0	14741	1116	39	2	2409	2	SLIT3	5	168175347	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	38931491	168175347	12739913	24	2794											
PSORS1C1	170679	broad.mit.edu	37	chr6	31106528	31106528	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgttaatcctgaccgacttTgccacatggagccagcaaac	8	13	0	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr6:31106528T>C	uc003nsl.1	+	5	413	c.139T>C	c.(139-141)TGC>CGC	p.C47R	PSORS1C1_uc010jsj.1_Intron|PSORS1C1_uc003nsn.1_Intron|PSORS1C2_uc003nso.3_Intron	NM_014068	NP_054787	Q9UIG5	PS1C1_HUMAN	SEEK1 protein	47										ovary(1)	1						TGACCGACTTTGCCACATGGA	0.557													C	31106528	C	C	31106528	3	2	44	1	0	0	0	0	1	0	0	0	12714	1812	63	4	149	4	PSORS1C1	6	31106528	Missense_Mutation	SNP	T	TCGA-06-0213-01A-01D-1491-08		31106528	140008539	25	2795											
MRAP2	112609	broad.mit.edu	37	chr6	84799086	84799086	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgaagtttgacatccccaaCtttgtgaacacagaccagaa	7	10	0	5			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr6:84799086C>A	uc003pkg.3	+	4	694	c.504C>A	c.(502-504)AAC>AAA	p.N168K	MRAP2_uc010kbo.2_Missense_Mutation_p.N82K	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	168					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						ACATCCCCAACTTTGTGAACA	0.502													A	84799086	A	A	84799086	3	1	44	1	0	0	0	0	1	0	0	0	9754	564	20	5	514	5	MRAP2	6	84799086	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	53692558	84799086	86315981	26	2796											
ULBP1	80329	broad.mit.edu	37	chr6	150291168	150291168	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagaaccaccctctctggcCccaggcacaacccaacccaa	5	20	2	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr6:150291168C>T	uc003qnp.2	+	4	685	c.642C>T	c.(640-642)GCC>GCT	p.A214A		NM_025218	NP_079494	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1 precursor	214					antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			pancreas(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		CCTCTCTGGCCCCAGGCACAA	0.562													T	150291168	T	T	150291168	2	4	44	1	0	0	0	0	0	0	0	1	16969	610	22	3		3	ULBP1	6	150291168	Silent	SNP	C	TCGA-06-0213-01A-01D-1491-08	65492082	150291168	20823899	27	2797											
PACRG	135138	broad.mit.edu	37	chr6	163235289	163235289	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attgcccttgagcatgattcGaaaggaaacaaaatcgcctg	9	9	0	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr6:163235289G>A	uc003qua.2	+	3	491	c.267G>A	c.(265-267)TCG>TCA	p.S89S	PACRG_uc003qub.2_Silent_p.S89S|PACRG_uc003quc.2_Silent_p.S89S	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	89											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		AGCATGATTCGAAAGGAAACA	0.517													A	163235289	A	A	163235289	2	1	44	1	0	0	0	0	0	0	0	1	11370	1045	37	2		2	PACRG	6	163235289	Silent	SNP	G	TCGA-06-0213-01A-01D-1491-08	12944121	163235289	7879778	28	2798											
NPSR1	387129	broad.mit.edu	37	chr7	34698051	34698051	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gccaacttcacagagggcagCttcgattccagtgggaccgg	13	12	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr7:34698051C>A	uc003teg.1	+	1	155	c.27C>A	c.(25-27)AGC>AGA	p.S9R	AAA1_uc010kwo.1_Intron|AAA1_uc010kwp.1_Intron|AAA1_uc003tdz.2_Intron|AAA1_uc010kwq.1_Intron|AAA1_uc003teb.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.S9R|NPSR1_uc010kwt.1_5'UTR|NPSR1_uc010kwu.1_5'UTR|NPSR1_uc010kwv.1_Missense_Mutation_p.S9R|NPSR1_uc003tei.1_Missense_Mutation_p.S9R|NPSR1_uc010kww.1_Missense_Mutation_p.S9R|NPSR1_uc011kar.1_Missense_Mutation_p.S9R	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	9	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	CAGAGGGCAGCTTCGATTCCA	0.572													A	34698051	A	A	34698051	3	1	44	1	0	0	0	0	1	0	0	0	10600	796	28	5	29	5	NPSR1	7	34698051	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08		34698051	124440612	29	2799											
WBSCR17	64409	broad.mit.edu	37	chr7	70597924	70597924	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacgagatccggccgcgcGccgaggtggccaacctcagc	13	17	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr7:70597924G>A	uc003tvy.2	+	1	136	c.136G>A	c.(136-138)GCC>ACC	p.A46T		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	46	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CCGGCCGCGCGCCGAGGTGGC	0.677													A	70597924	A	A	70597924	3	1	44	1	0	0	0	0	1	0	0	0	17261	1087	38	1	138	1	WBSCR17	7	70597924	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	35899873	70597924	88540739	30	2800											
SRCRB4D	136853	broad.mit.edu	37	chr7	76033702	76033702	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccatctcccaacctccaccCccagcgcttctcatccagct	3	23	2	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr7:76033702C>T	uc003ufb.2	-	2	403	c.55G>A	c.(55-57)GGG>AGG	p.G19R	ZP3_uc003ufc.3_Intron	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	19						extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						AACCTCCACCCCCAGCGCTTC	0.597													T	76033702	T	T	76033702	3	4	44	1	0	0	0	0	1	0	0	0	15136	623	22	3	1712	3	SRCRB4D	7	76033702	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	5435778	76033702	83104961	31	2801											
RELN	5649	broad.mit.edu	37	chr7	103417022	103417022	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctccttgttcacacaactGctgggctaaagcatctttga	7	12	2	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr7:103417022G>A	uc003vca.2	-	4	686	c.526C>T	c.(526-528)CAG>TAG	p.Q176*	RELN_uc010liz.2_Nonsense_Mutation_p.Q176*	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	176	Reelin.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCACACAACTGCTGGGCTAAA	0.403													A	103417022	A	A	103417022	4	1	44	1	0	0	0	0	0	1	0	0	13220	1328	46	3	10104	3	RELN	7	103417022	Nonsense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	27383320	103417022	55721641	32	2802											
CTTNBP2	83992	broad.mit.edu	37	chr7	117432019	117432019	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aggagctatgcctggtgtttGagcggtgggaggggcagcgt	20	6	0	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr7:117432019G>T	uc003vjf.2	-	4	1323	c.1231C>A	c.(1231-1233)CAA>AAA	p.Q411K		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	411	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CCTGGTGTTTGAGCGGTGGGA	0.522													T	117432019	T	T	117432019	3	4	44	1	0	0	0	0	1	0	0	0	4045	1299	45	5	3840	5	CTTNBP2	7	117432019	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	14014997	117432019	41706644	33	2803											
GALT	2592	broad.mit.edu	37	chr9	34648454	34648454	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaggagctactcaggaagGtgggagagagccaagccctg	16	10	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr9:34648454G>A	uc003zve.2	+	7	754	c.687_splice	c.e7+1	p.K229_splice	GALT_uc003zvf.2_Splice_Site_p.K120_splice|GALT_uc003zvg.2_Splice_Site_p.K101_splice|GALT_uc003zvh.2_Splice_Site_p.K181_splice|GALT_uc011lop.1_Splice_Site_p.K181_splice|IL11RA_uc003zvi.2_5'Flank	NM_000155	NP_000146	P07902	GALT_HUMAN	galactose-1-phosphate uridylyltransferase						galactose catabolic process	cytosol	UDP-glucose:hexose-1-phosphate uridylyltransferase activity|zinc ion binding				0	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		ACTCAGGAAGGTGGGAGAGAG	0.453									Galactosemia				A	34648454	A	A	34648454	5	1	44	1	0	0	0	0	0	0	1	0	6230	1275	44	3	714	3	GALT	9	34648454	Splice_Site	SNP	G	TCGA-06-0213-01A-01D-1491-08		34648454	106564977	34	2804											
TDRD7	23424	broad.mit.edu	37	chr9	100245441	100245441	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gccacctcctgtccacttatCaaagccaggggaacacatgg	9	14	1	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr9:100245441C>G	uc004axj.2	+	15	2948	c.2723C>G	c.(2722-2724)TCA>TGA	p.S908*	TDRD7_uc011lux.1_Nonsense_Mutation_p.S834*|TDRD7_uc010msp.1_Nonsense_Mutation_p.S160*|TDRD7_uc011luy.1_Nonsense_Mutation_p.S228*	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	908	Interacts with CDK17 (By similarity).|Interacts with CABLES1 (By similarity).				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				GTCCACTTATCAAAGCCAGGG	0.498													G	100245441	G	G	100245441	4	3	44	1	0	0	0	0	0	1	0	0	15732	838	29	5	2777	5	TDRD7	9	100245441	Nonsense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	65596987	100245441	40967990	35	2805											
TNFSF15	9966	broad.mit.edu	37	chr9	117552981	117552981	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtctggcttgtttggtcgGcctgcttgtctgatttcact	12	9	3	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr9:117552981G>A	uc004bjh.2	-	4	623	c.507C>T	c.(505-507)GGC>GGT	p.G169G	TNFSF15_uc004bjg.2_Silent_p.G110G	NM_005118	NP_005109	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily,	169	Extracellular (Potential).				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding				0						TGTTTGGTCGGCCTGCTTGTC	0.527													A	117552981	A	A	117552981	2	1	44	1	0	0	0	0	0	0	0	1	16305	1190	42	3		3	TNFSF15	9	117552981	Silent	SNP	G	TCGA-06-0213-01A-01D-1491-08	17307540	117552981	23660450	36	2806											
MPP7	143098	broad.mit.edu	37	chr10	28420514	28420514	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttctctatttttgaccagaCggattatttttactgagtct	7	7	2	3			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr10:28420514C>T	uc001iua.1	-	8	826	c.422G>A	c.(421-423)CGT>CAT	p.R141H	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Missense_Mutation_p.R141H|MPP7_uc009xla.2_Missense_Mutation_p.R141H|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	141	PDZ.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TTTGACCAGACGGATTATTTT	0.423													T	28420514	T	T	28420514	3	4	44	1	0	0	0	0	1	0	0	0	9739	536	19	1	1356	1	MPP7	10	28420514	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08		28420514	107114233	37	2807											
ZNF239	8187	broad.mit.edu	37	chr10	44052995	44052995	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cacagttattatggtcacagGgtttctcctctgtatgagct	9	9	3	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr10:44052995G>T	uc001jaw.3	-	2	1186	c.533C>A	c.(532-534)CCC>CAC	p.P178H	ZNF239_uc001jax.3_Missense_Mutation_p.P178H|ZNF239_uc009xmj.2_Missense_Mutation_p.P178H|ZNF239_uc009xmk.2_Missense_Mutation_p.P178H	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						ATGGTCACAGGGTTTCTCCTC	0.428													T	44052995	T	T	44052995	3	4	44	1	0	0	0	0	1	0	0	0	17788	1232	43	5	847	5	ZNF239	10	44052995	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	15632481	44052995	91481752	38	2808											
PTEN	5728	broad.mit.edu	37	chr10	89720852	89720852	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaataaagacaaagccaacCgatacttttctccaaatttt	3	10	1	1	rs121909231		TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr10:89720852C>T	uc001kfb.2	+	9	2034	c.1003C>T	c.(1003-1005)CGA>TGA	p.R335*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	335	C2 tensin-type.			KANKDKANR->AAGADAANA: Reduces growth suppression activity and promotes anchorage-independent growth. Reduces binding to phospholipid membranes in vitro; phosphatase activity towards PtdIns(3,4,5)P3 is not affected.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R335*(21)|p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.R335fs*8(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.R335fs*4(1)|p.R335fs*7(1)|p.W274_F341del(1)|p.R335R(1)|p.D326_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CAAAGCCAACCGATACTTTTC	0.333		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89720852	T	T	89720852	4	4	44	1	0	0	0	0	0	1	0	0	12738	644	23	2	1033	2	PTEN	10	89720852	Nonsense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	45667857	89720852	45813895	39	2809											
KNDC1	85442	broad.mit.edu	37	chr10	135038289	135038289	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttcagcggtgccgacatttcCacactcgccgcagatagcag	10	14	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr10:135038289C>G	uc001llz.1	+	30	5146	c.5145C>G	c.(5143-5145)TCC>TCG	p.S1715S		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1715	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCGACATTTCCACACTCGCCG	0.582													G	135038289	G	G	135038289	2	3	44	1	0	0	0	0	0	0	0	1	8426	581	21	5		5	KNDC1	10	135038289	Silent	SNP	C	TCGA-06-0213-01A-01D-1491-08	45317437	135038289	496458	40	2810											
OR5L2	26338	broad.mit.edu	37	chr11	55594994	55594994	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcctagggtgcatggtgcaAttctacttgttttgcacatg	10	8	1	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr11:55594994A>G	uc001nhy.1	+	1	300	c.300A>G	c.(298-300)CAA>CAG	p.Q100Q		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	100	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				GCATGGTGCAATTCTACTTGT	0.473										HNSCC(27;0.073)			G	55594994	G	G	55594994	2	3	44	1	0	0	0	0	0	0	0	1	11171	98	4	4		4	OR5L2	11	55594994	Silent	SNP	A	TCGA-06-0213-01A-01D-1491-08		55594994	79411522	41	2811											
GLYATL1	92292	broad.mit.edu	37	chr11	58723492	58723492	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gctacccacagaatctagttCcattttagacaatgaagctg	7	10	1	3			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr11:58723492C>T	uc001nnf.2	+	8	1277	c.901C>T	c.(901-903)CCA>TCA	p.P301S	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.P332S|GLYATL1_uc001nni.1_Missense_Mutation_p.P301S|GLYATL1_uc001nnj.1_Missense_Mutation_p.P301S			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	301						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	GAATCTAGTTCCATTTTAGAC	0.388													T	58723492	T	T	58723492	3	4	44	1	0	0	0	0	1	0	0	0	6480	855	30	3	1020	3	GLYATL1	11	58723492	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	3128498	58723492	76283024	42	2812											
FAT3	120114	broad.mit.edu	37	chr11	92532317	92532317	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcccctttgaccgtgaagaAcaagagttatatgagctggt	11	8	0	5			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr11:92532317A>G	uc001pdj.3	+	9	6155	c.6138A>G	c.(6136-6138)GAA>GAG	p.E2046E		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2046	Extracellular (Potential).|Cadherin 18.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACCGTGAAGAACAAGAGTTAT	0.463										TCGA Ovarian(4;0.039)			G	92532317	G	G	92532317	2	3	44	1	0	0	0	0	0	0	0	1	5691	40	2	4		4	FAT3	11	92532317	Silent	SNP	A	TCGA-06-0213-01A-01D-1491-08	33808825	92532317	42474199	43	2813											
TTC12	54970	broad.mit.edu	37	chr11	113233171	113233171	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcttcctctctgaaaattGttgaggaggccttgcgagca	10	9	2	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr11:113233171G>A	uc001pnu.2	+	19	1768	c.1663G>A	c.(1663-1665)GTT>ATT	p.V555I	TTC12_uc001pnv.2_Missense_Mutation_p.V561I|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Missense_Mutation_p.V405I	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	555							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TCTGAAAATTGTTGAGGAGGC	0.428													A	113233171	A	A	113233171	3	1	44	1	0	0	0	0	1	0	0	0	16676	1377	48	3	1733	3	TTC12	11	113233171	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	20700854	113233171	21773345	44	2814											
SRPR	6734	broad.mit.edu	37	chr11	126137085	126137085	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cttgccttccttcttggcccCcttttttttgctattctttg	5	13	2	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr11:126137085C>G	uc001qdh.2	-	4	562	c.511G>C	c.(511-513)GGG>CGG	p.G171R	SRPR_uc010sbm.1_Missense_Mutation_p.G143R|FOXRED1_uc001qdi.2_5'Flank|FOXRED1_uc010sbn.1_5'Flank|FOXRED1_uc010sbo.1_5'Flank|FOXRED1_uc010sbp.1_5'Flank|FOXRED1_uc010sbq.1_5'Flank|FOXRED1_uc001qdj.2_5'Flank|FOXRED1_uc010sbr.1_5'Flank	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor	171					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		TTCTTGGCCCCCTTTTTTTTG	0.438													G	126137085	G	G	126137085	3	3	44	1	0	0	0	0	1	0	0	0	15161	623	22	5	1449	5	SRPR	11	126137085	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	12903914	126137085	8869431	45	2815											
ACAD8	27034	broad.mit.edu	37	chr11	134129623	134129623	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacccctggcctcagctttgGcaagaaggagaaaaaggtga	13	9	1	3			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr11:134129623G>T	uc001qhk.2	+	6	750	c.689G>T	c.(688-690)GGC>GTC	p.G230V	ACAD8_uc009zdc.2_3'UTR|ACAD8_uc010sco.1_Missense_Mutation_p.G132V|ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.G153V|ACAD8_uc001qhl.2_Missense_Mutation_p.G103V|ACAD8_uc010scr.1_Missense_Mutation_p.G192V|ACAD8_uc009zde.1_Missense_Mutation_p.G103V	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	230					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		CTCAGCTTTGGCAAGAAGGAG	0.517													T	134129623	T	T	134129623	3	4	44	1	0	0	0	0	1	0	0	0	110	1203	42	5	711	5	ACAD8	11	134129623	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	7992538	134129623	876893	46	2816											
CD163L1	283316	broad.mit.edu	37	chr12	7586265	7586265	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagggaccgtctccattgacCagcctcaactccaaatctgt	7	15	3	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr12:7586265C>T	uc001qsy.2	-	3	176	c.150G>A	c.(148-150)CTG>CTA	p.L50L	CD163L1_uc010sge.1_Silent_p.L50L	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	50	SRCR 1.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CTCCATTGACCAGCCTCAACT	0.473													T	7586265	T	T	7586265	2	4	44	1	0	0	0	0	0	0	0	1	2968	581	21	3		3	CD163L1	12	7586265	Silent	SNP	C	TCGA-06-0213-01A-01D-1491-08		7586265	126265630	47	2817											
PIK3C2G	5288	broad.mit.edu	37	chr12	18435035	18435035	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatggcatattcttggcaaaCggatccaaatcctaatgaat	7	8	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr12:18435035C>T	uc001rdt.2	+	2	136	c.20C>T	c.(19-21)ACG>ATG	p.T7M	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.T7M|PIK3C2G_uc010sic.1_Translation_Start_Site	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	7					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.T7M(1)		lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TCTTGGCAAACGGATCCAAAT	0.353													T	18435035	T	T	18435035	3	4	44	1	0	0	0	0	1	0	0	0	11911	536	19	1	22	1	PIK3C2G	12	18435035	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	10848770	18435035	115416860	48	2818											
KRT7	3855	broad.mit.edu	37	chr12	52642505	52642505	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctcctgaaggcttattccatCcggaccgcatccgccagtcg	9	16	0	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr12:52642505C>A	uc001saa.1	+	9	1498	c.1371C>A	c.(1369-1371)ATC>ATA	p.I457I	KRT86_uc010snq.1_5'Flank	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	457	Tail.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		CTTATTCCATCCGGACCGCAT	0.647													A	52642505	A	A	52642505	2	1	44	1	0	0	0	0	0	0	0	1	8483	845	30	5		5	KRT7	12	52642505	Silent	SNP	C	TCGA-06-0213-01A-01D-1491-08	34207470	52642505	81209390	49	2819											
KRT2	3849	broad.mit.edu	37	chr12	53039092	53039092	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgcctctggagccagactgtCggcctccagagccataactg	11	15	1	2	rs142557360		TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr12:53039092C>T	uc001sat.2	-	9	1664	c.1631G>A	c.(1630-1632)CGA>CAA	p.R544Q		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	544	Tail.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		GCCAGACTGTCGGCCTCCAGA	0.572													T	53039092	T	T	53039092	3	4	44	1	0	0	0	0	1	0	0	0	8457	884	31	2	292	2	KRT2	12	53039092	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	396587	53039092	80812803	50	2820											
DCN	1634	broad.mit.edu	37	chr12	91552214	91552214	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attcttggacagataaagtcGttccaacttcaccaaaggtg	8	9	2	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr12:91552214G>A	uc001tbs.2	-	3	491	c.397C>T	c.(397-399)CGA>TGA	p.R133*	DCN_uc001tbo.2_Intron|DCN_uc001tbp.2_Intron|DCN_uc001tbq.2_Intron|DCN_uc001tbr.2_Intron|DCN_uc001tbt.2_Nonsense_Mutation_p.R133*|DCN_uc001tbu.2_Nonsense_Mutation_p.R133*	NM_133503	NP_598010	P07585	PGS2_HUMAN	decorin isoform a preproprotein	133	LRR 3.				organ morphogenesis	extracellular space		p.R133*(1)		central_nervous_system(2)|ovary(1)|lung(1)	4						AGATAAAGTCGTTCCAACTTC	0.408													A	91552214	A	A	91552214	4	1	44	1	0	0	0	0	0	1	0	0	4297	1153	40	1	702	1	DCN	12	91552214	Nonsense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	38513122	91552214	42299681	51	2821											
POLR3B	55703	broad.mit.edu	37	chr12	106824234	106824234	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggggaatgctgtgtccttcgGacactcctgaaggagaggta	15	8	0	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr12:106824234G>A	uc001tlp.2	+	14	1669	c.1447G>A	c.(1447-1449)GAC>AAC	p.D483N	POLR3B_uc001tlq.2_Missense_Mutation_p.D425N	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	483					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						GTGTCCTTCGGACACTCCTGA	0.522													A	106824234	A	A	106824234	3	1	44	1	0	0	0	0	1	0	0	0	12229	1174	41	3	1501	3	POLR3B	12	106824234	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	15272020	106824234	27027661	52	2822											
RIMBP2	23504	broad.mit.edu	37	chr12	130921520	130921520	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccttccggggcccacgggcGgctccagcatgtgcccatgc	14	17	0	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr12:130921520G>A	uc001uil.2	-	10	2086	c.1922C>T	c.(1921-1923)CCG>CTG	p.P641L	RIMBP2_uc001uim.2_Missense_Mutation_p.P549L|RIMBP2_uc001uin.1_Missense_Mutation_p.P300L	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	641	Pro-rich.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCCCACGGGCGGCTCCAGCAT	0.711													A	130921520	A	A	130921520	3	1	44	1	0	0	0	0	1	0	0	0	13363	1116	39	2	1276	2	RIMBP2	12	130921520	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	24097286	130921520	2930375	53	2823											
PARP4	143	broad.mit.edu	37	chr13	25016086	25016086	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaacttttggaatatcaggAaaaggcgactcattctcatc	8	8	3	0	rs113538547		TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr13:25016086A>G	uc001upl.2	-	30	3670	c.3564T>C	c.(3562-3564)TTT>TTC	p.F1188F		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1188					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		GAATATCAGGAAAAGGCGACT	0.413													G	25016086	G	G	25016086	2	3	44	1	0	0	0	0	0	0	0	1	11463	243	9	4		4	PARP4	13	25016086	Silent	SNP	A	TCGA-06-0213-01A-01D-1491-08		25016086	90153792	54	2824											
RB1	5925	broad.mit.edu	37	chr13	49030485	49030485	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttcactgttttataaaaaaGgttagtagatgattattttc	6	3	1	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr13:49030485G>C	uc001vcb.2	+	19	2126	c.1960G>C	c.(1960-1962)GTG>CTG	p.V654L		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	654	Pocket; binds T and E1A.|Domain B.		V -> E (in RB).		androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)|p.V654fs*4(1)|p.V654fs*6(1)|p.V654L(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTATAAAAAAGGTTAGTAGAT	0.229		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			C	49030485	C	C	49030485	3	2	44	1	0	0	0	0	1	0	0	0	13098	1014	35	5	2034	5	RB1	13	49030485	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	24014399	49030485	66139393	55	2825											
RIN3	79890	broad.mit.edu	37	chr14	93118565	93118565	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcccctcccagacgccgcGtttccgagagggtgtcctta	11	16	0	2	rs145578489	byFrequency	TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr14:93118565G>A	uc001yap.2	+	6	1323	c.1171G>A	c.(1171-1173)GTT>ATT	p.V391I	RIN3_uc010auk.2_Missense_Mutation_p.V53I|RIN3_uc001yaq.2_Missense_Mutation_p.V316I|RIN3_uc001yar.1_Missense_Mutation_p.V53I|RIN3_uc001yas.1_Missense_Mutation_p.V53I	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	391	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CAGACGCCGCGTTTCCGAGAG	0.667													A	93118565	A	A	93118565	3	1	44	1	0	0	0	0	1	0	0	0	13373	1145	40	1	1193	1	RIN3	14	93118565	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08		93118565	14230975	56	2826											
RCOR1	23186	broad.mit.edu	37	chr14	103174815	103174815	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tgtttagcttccagataaatCtatagcaagtctggtgaaat	8	6	2	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr14:103174815C>G	uc001ymb.2	+	6	665	c.665C>G	c.(664-666)TCT>TGT	p.S222C		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	222	Interaction with HDAC1.|SANT 1.				blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						CCAGATAAATCTATAGCAAGT	0.299													G	103174815	G	G	103174815	3	3	44	1	0	0	0	0	1	0	0	0	13182	913	32	5	687	5	RCOR1	14	103174815	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08	10056250	103174815	4174725	57	2827											
JAG2	3714	broad.mit.edu	37	chr14	105617967	105617967	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtgcagacactcaccaagGgcacaggtgggcccgctcca	12	15	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr14:105617967G>A	uc001yqg.2	-	8	1553	c.1149C>T	c.(1147-1149)GCC>GCT	p.A383A	JAG2_uc001yqf.2_5'Flank|JAG2_uc001yqh.2_Silent_p.A383A	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	383	EGF-like 4.|Extracellular (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		ACTCACCAAGGGCACAGGTGG	0.652													A	105617967	A	A	105617967	2	1	44	1	0	0	0	0	0	0	0	1	7935	1219	43	3		3	JAG2	14	105617967	Silent	SNP	G	TCGA-06-0213-01A-01D-1491-08	2443152	105617967	1731573	58	2828											
TMC3	342125	broad.mit.edu	37	chr15	81624852	81624852	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctggcccacggacctcgGgaacctgccctggctgtggg	17	14	0	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr15:81624852G>A	uc002bgo.1	-	22	3211	c.3211C>T	c.(3211-3213)CCG>TCG	p.P1071S	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	1071	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						ACGGACCTCGGGAACCTGCCC	0.612													A	81624852	A	A	81624852	3	1	44	1	0	0	0	0	1	0	0	0	15983	1232	43	3	95	3	TMC3	15	81624852	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08		81624852	20906540	59	2829											
NPRL3	8131	broad.mit.edu	37	chr16	167362	167362	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttccctcttcggggaaggatCtgttttggagatctgtaaaa	11	7	3	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr16:167362C>G	uc002cfr.2	-	5	430	c.331G>C	c.(331-333)GAT>CAT	p.D111H	NPRL3_uc010uua.1_Intron|NPRL3_uc002cfp.1_RNA|NPRL3_uc002cfq.2_Intron|NPRL3_uc010uub.1_Intron|NPRL3_uc010uuc.1_Missense_Mutation_p.D33H|NPRL3_uc002cfs.1_Intron	NM_001077350	NP_001070818	Q12980	NPRL3_HUMAN	conserved gene telomeric to alpha globin cluster	111							protein binding			ovary(1)	1						GGGGAAGGATCTGTTTTGGAG	0.393													G	167362	G	G	167362	3	3	44	1	0	0	0	0	1	0	0	0	10598	913	32	5	1417	5	NPRL3	16	167362	Missense_Mutation	SNP	C	TCGA-06-0213-01A-01D-1491-08		167362	90187391	60	2830											
CX3CL1	6376	broad.mit.edu	37	chr16	57416501	57416501	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagcgtgtgtggggtcagGgacagagccccaggccagag	18	11	1	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr16:57416501G>A	uc002eli.2	+	3	818	c.751G>A	c.(751-753)GGA>AGA	p.G251R		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	251	Mucin-like stalk.|Extracellular (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						GTGGGGTCAGGGACAGAGCCC	0.692													A	57416501	A	A	57416501	3	1	44	1	0	0	0	0	1	0	0	0	4074	1233	43	3	761	3	CX3CL1	16	57416501	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	57249139	57416501	32938252	61	2831											
SCN4A	6329	broad.mit.edu	37	chr17	62018566	62018566	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcttgagggcgtccatttcCccagagtcacccaggacctc	10	15	1	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr17:62018566C>T	uc002jds.1	-	24	5153	c.5076G>A	c.(5074-5076)GGG>GGA	p.G1692G		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1692					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	CGTCCATTTCCCCAGAGTCAC	0.577													T	62018566	T	T	62018566	2	4	44	1	0	0	0	0	0	0	0	1	13920	610	22	3		3	SCN4A	17	62018566	Silent	SNP	C	TCGA-06-0213-01A-01D-1491-08		62018566	19176644	62	2832											
ITGB4	3691	broad.mit.edu	37	chr17	73745120	73745120	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccaccaccatcatcatcaggGacccaggtaggcagagcctg	10	15	3	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr17:73745120G>A	uc002jpg.2	+	27	3497	c.3310G>A	c.(3310-3312)GAC>AAC	p.D1104N	ITGB4_uc002jph.2_Missense_Mutation_p.D1104N|ITGB4_uc002jpi.3_Missense_Mutation_p.D1104N|ITGB4_uc002jpj.2_Missense_Mutation_p.D1104N	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1104	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CATCATCAGGGACCCAGGTAG	0.552													A	73745120	A	A	73745120	3	1	44	1	0	0	0	0	1	0	0	0	7897	1174	41	3	3412	3	ITGB4	17	73745120	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	11726554	73745120	7450090	63	2833											
PRKCSH	5589	broad.mit.edu	37	chr19	11559895	11559895	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgtctctcacagcaccTggggctcatggattggcccc	11	15	3	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr19:11559895T>C	uc002mrt.2	+	16	1681	c.1345T>C	c.(1345-1347)TGG>CGG	p.W449R	PRKCSH_uc002mru.2_Missense_Mutation_p.W446R|PRKCSH_uc010xlz.1_Missense_Mutation_p.W456R|PRKCSH_uc010dya.2_Missense_Mutation_p.W231R|PRKCSH_uc010dyb.2_Missense_Mutation_p.W446R	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1	449	PRKCSH.				innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0						TCACAGCACCTGGGGCTCATG	0.662													C	11559895	C	C	11559895	3	2	44	1	0	0	0	0	1	0	0	0	12516	1580	55	4	1424	4	PRKCSH	19	11559895	Missense_Mutation	SNP	T	TCGA-06-0213-01A-01D-1491-08		11559895	47569088	64	2834											
B3GNT8	374907	broad.mit.edu	37	chr19	41932546	41932546	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgggctcagggttggctggCgtggggcttggcggggtgcc	23	8	1	0			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr19:41932546C>T	uc002oqs.2	-	3	592	c.138G>A	c.(136-138)ACG>ACA	p.T46T	CYP2F1_uc010xvw.1_Intron|B3GNT8_uc002oqt.1_Intron	NM_198540	NP_940942	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal	46	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity				0						GGTTGGCTGGCGTGGGGCTTG	0.662													T	41932546	T	T	41932546	2	4	44	1	0	0	0	0	0	0	0	1	1263	755	27	1		1	B3GNT8	19	41932546	Silent	SNP	C	TCGA-06-0213-01A-01D-1491-08	30372651	41932546	17196437	65	2835											
SIRPA	140885	broad.mit.edu	37	chr20	1895993	1895993	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acttttccatccgcatcggtAacatcaccccagcagatgcc	6	16	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chr20:1895993A>G	uc002wfq.2	+	3	688	c.328A>G	c.(328-330)AAC>GAC	p.N110D	SIRPA_uc010zps.1_Missense_Mutation_p.N90D|SIRPA_uc002wfr.2_Missense_Mutation_p.N110D|SIRPA_uc002wfs.2_Missense_Mutation_p.N110D|SIRPA_uc002wft.2_Missense_Mutation_p.N110D	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	110	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		CCGCATCGGTAACATCACCCC	0.502													G	1895993	G	G	1895993	3	3	44	1	0	0	0	0	1	0	0	0	14332	362	13	4	334	4	SIRPA	20	1895993	Missense_Mutation	SNP	A	TCGA-06-0213-01A-01D-1491-08		1895993	61129527	66	2836											
CACNA1F	778	broad.mit.edu	37	chrX	49077514	49077514	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caggccttcattctcctgtgGgagatccttctcattgctct	8	13	4	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chrX:49077514G>T	uc004dnb.2	-	18	2409	c.2347C>A	c.(2347-2349)CCA>ACA	p.P783T	CACNA1F_uc010nip.2_Missense_Mutation_p.P772T	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	783	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	TTCTCCTGTGGGAGATCCTTC	0.498													T	49077514	T	T	49077514	3	4	44	1	0	0	0	0	1	0	0	0	2543	1232	43	5	3710	5	CACNA1F	23	49077514	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08		49077514	106193046	67	2837											
TAF1	6872	broad.mit.edu	37	chrX	70587386	70587386	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcaggcttgggggctttggGgctgggcagcctgatcactg	19	9	1	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chrX:70587386G>A	uc004dzu.3	+	2	269	c.218G>A	c.(217-219)GGG>GAG	p.G73E	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.G73E	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	73	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity	p.G73E(1)		ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				GGGGCTTTGGGGCTGGGCAGC	0.522													A	70587386	A	A	70587386	3	1	44	1	0	0	0	0	1	0	0	0	15510	1232	43	3	224	3	TAF1	23	70587386	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	21509872	70587386	84683174	68	2838											
ATRX	546	broad.mit.edu	37	chrX	76872167	76872167	+	Frame_Shift_Del	DEL	A	-	-													catattcgtgttttggaggcAagaattttgttaatgctgta							TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chrX:76872167delA	uc004ecp.3	-	22	5712	c.5480delT	c.(5479-5481)TTGfs	p.L1827fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.L1789fs|ATRX_uc004eco.3_Frame_Shift_Del_p.L1612fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1827					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTTTGGAGGCAAGAATTTTGT	0.318			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						-	76872167	-	-	76872167	7	5	44	1	0	1	0	1	0	0	0	0	1208	131	5	0	2054	0	ATRX	23	76872167	Frame_Shift_Del	DEL	A	TCGA-06-0213-01A-01D-1491-08	6284781	76872167	78398393	69	2839											
ARMCX2	9823	broad.mit.edu	37	chrX	100910782	100910782	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctccagatgtagtgcataagTaaaaaagggaacctttattg	9	6	0	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chrX:100910782T>G	uc004eid.2	-	3	2148	c.1793A>C	c.(1792-1794)TAC>TCC	p.Y598S	ARMCX2_uc004eie.3_Missense_Mutation_p.Y598S|ARMCX2_uc004eif.3_Missense_Mutation_p.Y598S|ARMCX2_uc004eig.3_Missense_Mutation_p.Y598S|ARMCX2_uc010nnt.2_Missense_Mutation_p.Y598S	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	598						integral to membrane	binding			ovary(6)	6						AGTGCATAAGTAAAAAAGGGA	0.328													G	100910782	G	G	100910782	3	3	44	1	0	0	0	0	1	0	0	0	960	1638	57	5	109	5	ARMCX2	23	100910782	Missense_Mutation	SNP	T	TCGA-06-0213-01A-01D-1491-08	24038615	100910782	54359778	70	2840											
RNF128	79589	broad.mit.edu	37	chrX	106038858	106038858	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcaaattctgtggcagtggAtgttattcctcatgttgaca	10	7	2	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chrX:106038858A>G	uc004eml.2	+	7	1452	c.1202A>G	c.(1201-1203)GAT>GGT	p.D401G	RNF128_uc004emk.2_Missense_Mutation_p.D375G	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	401						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTGGCAGTGGATGTTATTCCT	0.358													G	106038858	G	G	106038858	3	3	44	1	0	0	0	0	1	0	0	0	13436	333	12	4	1638	4	RNF128	23	106038858	Missense_Mutation	SNP	A	TCGA-06-0213-01A-01D-1491-08	5128076	106038858	49231702	71	2841											
LAMP2	3920	broad.mit.edu	37	chrX	119580241	119580241	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgagaacggcagctgcctgtGgagtgagttgtattggggtt	17	5	0	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chrX:119580241G>T	uc004est.3	-	6	963	c.783C>A	c.(781-783)TCC>TCA	p.S261S	LAMP2_uc004ess.3_Silent_p.S261S|LAMP2_uc011mtz.1_Silent_p.S150S|LAMP2_uc011mua.1_Silent_p.S214S|LAMP2_uc010nqp.1_Silent_p.S261S	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	261	Lumenal (Potential).|Second lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						AGCTGCCTGTGGAGTGAGTTG	0.423													T	119580241	T	T	119580241	2	4	44	1	0	0	0	0	0	0	0	1	8618	1335	47	5		5	LAMP2	23	119580241	Silent	SNP	G	TCGA-06-0213-01A-01D-1491-08	13541383	119580241	35690319	72	2842											
GRIA3	2892	broad.mit.edu	37	chrX	122528885	122528885	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acattacaggtttccagattGtcaacaatgaaaaccctatg	6	9	1	2			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chrX:122528885G>A	uc004etq.3	+	7	1110	c.817G>A	c.(817-819)GTC>ATC	p.V273I	GRIA3_uc004etr.3_Missense_Mutation_p.V273I|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.V257I	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	273	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	TTTCCAGATTGTCAACAATGA	0.438													A	122528885	A	A	122528885	3	1	44	1	0	0	0	0	1	0	0	0	6769	1377	48	3	839	3	GRIA3	23	122528885	Missense_Mutation	SNP	G	TCGA-06-0213-01A-01D-1491-08	2948644	122528885	32741675	73	2843											
THOC2	57187	broad.mit.edu	37	chrX	122761607	122761607	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttattgacttctcgttcataGctggtgtgtggaactgcaag	11	7	2	1			TCGA-06-0213-01A-01D-1491-08	TCGA-06-0213-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	885f9df7-fc27-43c2-9acc-833c410b2db1	0206ce3d-4c48-4f58-8eeb-07a34adc9fcd	g.chrX:122761607G>A	uc004etu.2	-	23	2726	c.2694C>T	c.(2692-2694)AGC>AGT	p.S898S	THOC2_uc011muh.1_Silent_p.S823S	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	898	Potential.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						CTCGTTCATAGCTGGTGTGTG	0.388													A	122761607	A	A	122761607	2	1	44	1	0	0	0	0	0	0	0	1	15862	962	34	3		3	THOC2	23	122761607	Silent	SNP	G	TCGA-06-0213-01A-01D-1491-08	232722	122761607	32508953	74	2844											
CROCC	9696	broad.mit.edu	37	chr1	17266398	17266398	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacaccccaggacatgcgtGggcgctatgaggcaagccag	13	14	0	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:17266398G>A	uc001azt.2	+	13	1687	c.1618G>A	c.(1618-1620)GGG>AGG	p.G540R	CROCC_uc009voy.1_Missense_Mutation_p.G243R|CROCC_uc009voz.1_Missense_Mutation_p.G303R|CROCC_uc001azu.2_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	540					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGACATGCGTGGGCGCTATGA	0.647													A	17266398	A	A	17266398	3	1	45	1	0	0	0	0	1	0	0	0	3893	1348	47	3	1668	3	CROCC	1	17266398	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08		17266398	231984223	1	2845											
CLIC4	25932	broad.mit.edu	37	chr1	25124266	25124266	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgaaagcataggaaactgcCccttttcccagaggctcttc	9	12	1	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:25124266C>T	uc001bjo.2	+	2	391	c.106C>T	c.(106-108)CCC>TCC	p.P36S	CLIC4_uc001bjn.2_RNA|CLIC4_uc001bjp.1_Intron	NM_013943	NP_039234	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	36	Required for insertion into the membrane (Probable).				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		AGGAAACTGCCCCTTTTCCCA	0.403													T	25124266	T	T	25124266	3	4	45	1	0	0	0	0	1	0	0	0	3528	623	22	3	112	3	CLIC4	1	25124266	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	7857868	25124266	224126355	2	2846											
BSDC1	55108	broad.mit.edu	37	chr1	32843632	32843632	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccgcccgctgcttcagggcGtccctccgggcctgctcctg	12	19	1	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:32843632G>A	uc001bvh.3	-	8	662	c.615C>T	c.(613-615)GAC>GAT	p.D205D	BSDC1_uc010ohg.1_Silent_p.D222D|BSDC1_uc010ohh.1_Silent_p.D149D|BSDC1_uc010ohi.1_Silent_p.D110D|BSDC1_uc001bvg.3_RNA|BSDC1_uc001bvj.2_Silent_p.D101D|BSDC1_uc001bvi.2_Silent_p.D222D	NM_018045	NP_060515	Q9NW68	BSDC1_HUMAN	BSD domain containing 1 isoform b	205							protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCTTCAGGGCGTCCCTCCGGG	0.622													A	32843632	A	A	32843632	2	1	45	1	0	0	0	0	0	0	0	1	1528	1136	40	1		1	BSDC1	1	32843632	Silent	SNP	G	TCGA-06-0214-01A-02D-1491-08	7719366	32843632	216406989	3	2847											
IL12RB2	3595	broad.mit.edu	37	chr1	67787302	67787302	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagatgcgtgcaagagaggcGatgtgactgtgaagccttcc	14	9	0	4			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:67787302G>A	uc001ddu.2	+	3	734	c.94G>A	c.(94-96)GAT>AAT	p.D32N	IL12RB2_uc010oqi.1_Missense_Mutation_p.D32N|IL12RB2_uc010oqj.1_Missense_Mutation_p.D32N|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.D32N|IL12RB2_uc010oqm.1_Missense_Mutation_p.D32N|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	32	Extracellular (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						CAAGAGAGGCGATGTGACTGT	0.393													A	67787302	A	A	67787302	3	1	45	1	0	0	0	0	1	0	0	0	7627	1058	37	2	100	2	IL12RB2	1	67787302	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	34943670	67787302	181463319	4	2848											
SYDE2	84144	broad.mit.edu	37	chr1	85624652	85624652	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attttgctataattttctccGatttttctatcttctgaagg	5	7	4	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:85624652G>A	uc009wcm.2	-	7	3415	c.3366C>T	c.(3364-3366)ATC>ATT	p.I1122I		NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	1122					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		AATTTTCTCCGATTTTTCTAT	0.363													A	85624652	A	A	85624652	2	1	45	1	0	0	0	0	0	0	0	1	15433	1048	37	2		2	SYDE2	1	85624652	Silent	SNP	G	TCGA-06-0214-01A-02D-1491-08	17837350	85624652	163625969	5	2849											
GBP3	2635	broad.mit.edu	37	chr1	89481028	89481028	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctaaggtgtgttctggctttTtggggtgaggcacacaccac	13	9	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:89481028T>C	uc001dmt.2	-	3	465	c.260A>G	c.(259-261)AAA>AGA	p.K87R	GBP3_uc010oss.1_Missense_Mutation_p.K8R|GBP3_uc001dmu.2_5'UTR|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	87						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		TTCTGGCTTTTTGGGGTGAGG	0.483													C	89481028	C	C	89481028	3	2	45	1	0	0	0	0	1	0	0	0	6275	1841	64	4	1563	4	GBP3	1	89481028	Missense_Mutation	SNP	T	TCGA-06-0214-01A-02D-1491-08	3856376	89481028	159769593	6	2850											
FAM46C	54855	broad.mit.edu	37	chr1	118166248	118166248	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtacagcaaccttcttgtgcGggacttcaggcccacagacc	10	14	2	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:118166248G>A	uc001ehe.2	+	2	957	c.758G>A	c.(757-759)CGG>CAG	p.R253Q		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	253											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		CTTCTTGTGCGGGACTTCAGG	0.517										Multiple Myeloma(3;1.13e-06)			A	118166248	A	A	118166248	3	1	45	1	0	0	0	0	1	0	0	0	5567	1116	39	2	760	2	FAM46C	1	118166248	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	28685220	118166248	131084373	7	2851											
HRNR	388697	broad.mit.edu	37	chr1	152192393	152192393	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccagactcatatgggccaCggcttgaagacctccctgag	11	13	1	4			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:152192393C>T	uc001ezt.1	-	3	1788	c.1712G>A	c.(1711-1713)CGT>CAT	p.R571H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	571					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATATGGGCCACGGCTTGAAGA	0.592													T	152192393	T	T	152192393	3	4	45	1	0	0	0	0	1	0	0	0	7359	536	19	1	6844	1	HRNR	1	152192393	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	34026145	152192393	97058228	8	2852											
SPTA1	6708	broad.mit.edu	37	chr1	158639308	158639308	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgactccttcagcaatctacGtctagtggcagccttttcac	7	13	4	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:158639308G>A	uc001fst.1	-	14	1922	c.1723C>T	c.(1723-1725)CGT>TGT	p.R575C		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	575	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGCAATCTACGTCTAGTGGCA	0.448													A	158639308	A	A	158639308	3	1	45	1	0	0	0	0	1	0	0	0	15115	1145	40	1	5692	1	SPTA1	1	158639308	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	6446915	158639308	90611313	9	2853											
CCDC19	25790	broad.mit.edu	37	chr1	159846467	159846467	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgtttccatcttcttccGcgcattttccttttcctttc	3	15	3	0	rs141229765		TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:159846467G>A	uc001fui.2	-	10	1249	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.R326W|CCDC19_uc001ful.2_Missense_Mutation_p.R326W|CCDC19_uc009wtc.1_Missense_Mutation_p.A410V	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	411	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			ATCTTCTTCCGCGCATTTTCC	0.577													A	159846467	A	A	159846467	3	1	45	1	0	0	0	0	1	0	0	0	2795	1086	38	1	436	1	CCDC19	1	159846467	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	1207159	159846467	89404154	10	2854											
ANGEL2	90806	broad.mit.edu	37	chr1	213178541	213178541	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtagcattgccaattgcGtcagcttaatatcacctcgc	7	13	2	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:213178541G>A	uc001hjz.2	-	5	1123	c.968C>T	c.(967-969)ACG>ATG	p.T323M	ANGEL2_uc010pto.1_Missense_Mutation_p.T197M|ANGEL2_uc010ptp.1_Missense_Mutation_p.T197M|ANGEL2_uc001hka.2_Missense_Mutation_p.T154M|ANGEL2_uc010ptq.1_RNA	NM_144567	NP_653168	Q5VTE6	ANGE2_HUMAN	LOC90806 protein	323											0				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		TGCCAATTGCGTCAGCTTAAT	0.453													A	213178541	A	A	213178541	3	1	45	1	0	0	0	0	1	0	0	0	609	1145	40	1	686	1	ANGEL2	1	213178541	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	53332074	213178541	36072080	11	2855											
USH2A	7399	broad.mit.edu	37	chr1	216143995	216143995	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagagcacaacctttggccGtgcatgcttggactctgaag	11	12	1	2	rs151057466	by1000genomes	TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:216143995G>A	uc001hku.1	-	36	7316	c.6929C>T	c.(6928-6930)ACG>ATG	p.T2310M		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2310	Fibronectin type-III 9.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACCTTTGGCCGTGCATGCTTG	0.408										HNSCC(13;0.011)			A	216143995	A	A	216143995	3	1	45	1	0	0	0	0	1	0	0	0	17033	1145	40	1	8827	1	USH2A	1	216143995	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	2965454	216143995	33106626	12	2856											
LYST	1130	broad.mit.edu	37	chr1	235940405	235940405	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgccagttccaccaatttcGtgcagaatgccttgaatagt	8	10	0	2	rs146990900		TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr1:235940405G>A	uc001hxj.2	-	17	5593	c.5418C>T	c.(5416-5418)CAC>CAT	p.H1806H	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1806					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CACCAATTTCGTGCAGAATGC	0.348									Chediak-Higashi_syndrome				A	235940405	A	A	235940405	2	1	45	1	0	0	0	0	0	0	0	1	9128	1136	40	1		1	LYST	1	235940405	Silent	SNP	G	TCGA-06-0214-01A-02D-1491-08	19796410	235940405	13310216	13	2857											
APOB	338	broad.mit.edu	37	chr2	21249770	21249770	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctttgttgacactgtctgGgaaaaatccttgcttcccaa	8	10	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr2:21249770G>A	uc002red.2	-	15	2262	c.2134C>T	c.(2134-2136)CCA>TCA	p.P712S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	712					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACACTGTCTGGGAAAAATCCT	0.413													A	21249770	A	A	21249770	3	1	45	1	0	0	0	0	1	0	0	0	785	1232	43	3	11617	3	APOB	2	21249770	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08		21249770	221949603	14	2858											
MSH6	2956	broad.mit.edu	37	chr2	48026476	48026476	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgaactggggctggtattcAtgaaaggcaactgggcccat	14	8	1	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr2:48026476A>G	uc002rwd.3	+	4	1506	c.1354A>G	c.(1354-1356)ATG>GTG	p.M452V	MSH6_uc002rwc.2_Missense_Mutation_p.M452V|MSH6_uc010fbj.2_Missense_Mutation_p.M150V|MSH6_uc010yoi.1_Missense_Mutation_p.M322V|MSH6_uc010yoj.1_Missense_Mutation_p.M150V	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	452					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GCTGGTATTCATGAAAGGCAA	0.453			Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				G	48026476	G	G	48026476	3	3	45	1	0	0	0	0	1	0	0	0	9874	217	8	4	1368	4	MSH6	2	48026476	Missense_Mutation	SNP	A	TCGA-06-0214-01A-02D-1491-08	26776706	48026476	195172897	15	2859											
SEMA4F	10505	broad.mit.edu	37	chr2	74900889	74900889	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaatctacttcttctttacGgagacttcccgagcatttga	7	10	3	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr2:74900889G>A	uc002sna.1	+	7	867	c.756G>A	c.(754-756)ACG>ACA	p.T252T	SEMA4F_uc010ysb.1_3'UTR|SEMA4F_uc010ffq.1_Silent_p.T219T|SEMA4F_uc010ffr.1_Intron|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Intron	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	252	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TCTTCTTTACGGAGACTTCCC	0.567													A	74900889	A	A	74900889	2	1	45	1	0	0	0	0	0	0	0	1	14035	1103	39	2		2	SEMA4F	2	74900889	Silent	SNP	G	TCGA-06-0214-01A-02D-1491-08	26874413	74900889	168298484	16	2860											
SDPR	8436	broad.mit.edu	37	chr2	192711627	192711627	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccagggtgctggaacttttCggcctgtgcagcgtcctctc	12	14	1	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr2:192711627C>T	uc002utb.2	-	1	355	c.25G>A	c.(25-27)GAA>AAA	p.E9K		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	9						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TGGAACTTTTCGGCCTGTGCA	0.612													T	192711627	T	T	192711627	3	4	45	1	0	0	0	0	1	0	0	0	13970	893	31	2	1260	2	SDPR	2	192711627	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	117810738	192711627	50487746	17	2861											
ACAA1	30	broad.mit.edu	37	chr3	38175476	38175476	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgattcgggccatgattgccCcggccccaggctgcagcaca	12	16	0	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr3:38175476C>T	uc003cht.2	-	3	497	c.290G>A	c.(289-291)GGG>GAG	p.G97E	ACAA1_uc003chu.2_Missense_Mutation_p.G97E|ACAA1_uc010hgy.2_Missense_Mutation_p.G97E|ACAA1_uc010hgz.2_Missense_Mutation_p.G97E|ACAA1_uc003chv.2_5'UTR	NM_001607	NP_001598	P09110	THIK_HUMAN	acetyl-Coenzyme A acyltransferase 1 isoform a	97					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy	peroxisomal matrix	acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0523)|Kidney(284;0.0657)		CATGATTGCCCCGGCCCCAGG	0.522													T	38175476	T	T	38175476	3	4	45	1	0	0	0	0	1	0	0	0	104	623	22	3	1024	3	ACAA1	3	38175476	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08		38175476	159846954	18	2862											
C3orf67	200844	broad.mit.edu	37	chr3	58870384	58870384	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgtcattagttgacagcttCgtggtataatatctgtaggc	10	7	2	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr3:58870384C>T	uc003dkt.1	-	7	636	c.227G>A	c.(226-228)CGA>CAA	p.R76Q	uc003dku.1_Intron|C3orf67_uc003dkv.1_5'UTR|C3orf67_uc003dkw.2_5'UTR	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	76											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		TTGACAGCTTCGTGGTATAAT	0.393													T	58870384	T	T	58870384	3	4	45	1	0	0	0	0	1	0	0	0	2241	884	31	2	1504	2	C3orf67	3	58870384	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	20694908	58870384	139152046	19	2863											
C3orf17	25871	broad.mit.edu	37	chr3	112738408	112738408	+	Silent	SNP	C	T	T													ccaagggccgcgccggggttCtgcactgtcactgcgctgcg							TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr3:112738408C>T	uc003dzr.2	-	1	148	c.87G>A	c.(85-87)CAG>CAA	p.Q29Q	C3orf17_uc011bhz.1_5'UTR|C3orf17_uc010hqh.2_5'UTR|C3orf17_uc003dzt.2_5'UTR|C3orf17_uc003dzs.2_5'UTR|C3orf17_uc010hqg.2_5'UTR|C3orf17_uc011bia.1_5'UTR|C3orf17_uc003dzu.2_Silent_p.Q28Q|C3orf17_uc011bib.1_5'UTR|C3orf17_uc011bic.1_5'UTR|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	29						integral to membrane					0						CGCCGGGGTTCTGCACTGTCA	0.731													T	112738408	T	T	112738408	2	4	45	1	0	0	0	0	0	0	0	1	2210	912	32	3		3	C3orf17	3	112738408	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08	53868024	112738408	85284022	20	2864	2	2									
C3orf17	25871	broad.mit.edu	37	chr3	112738411	112738411	+	Silent	SNP	C	T	T													agggccgcgccggggttctgCactgtcactgcgctgcggtt					rs144842364	byFrequency	TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr3:112738411C>T	uc003dzr.2	-	1	145	c.84G>A	c.(82-84)GTG>GTA	p.V28V	C3orf17_uc011bhz.1_5'UTR|C3orf17_uc010hqh.2_5'UTR|C3orf17_uc003dzt.2_5'UTR|C3orf17_uc003dzs.2_5'UTR|C3orf17_uc010hqg.2_5'UTR|C3orf17_uc011bia.1_5'UTR|C3orf17_uc003dzu.2_Silent_p.V27V|C3orf17_uc011bib.1_5'UTR|C3orf17_uc011bic.1_5'UTR|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	28						integral to membrane					0						CGGGGTTCTGCACTGTCACTG	0.726													T	112738411	T	T	112738411	2	4	45	1	0	0	0	0	0	0	0	1	2210	697	25	3		3	C3orf17	3	112738411	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08	3	112738411	85284019	21	2865	2	2									
C3orf17	25871	broad.mit.edu	37	chr3	112738459	112738459	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttagggattctcacacggttCcacggctccaggcccggcgg	13	14	1	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr3:112738459C>T	uc003dzr.2	-	1	97	c.36G>A	c.(34-36)TGG>TGA	p.W12*	C3orf17_uc011bhz.1_5'UTR|C3orf17_uc010hqh.2_5'UTR|C3orf17_uc003dzt.2_5'UTR|C3orf17_uc003dzs.2_5'UTR|C3orf17_uc010hqg.2_5'UTR|C3orf17_uc011bia.1_5'UTR|C3orf17_uc003dzu.2_Nonsense_Mutation_p.W11*|C3orf17_uc011bib.1_5'UTR|C3orf17_uc011bic.1_5'UTR|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	12						integral to membrane					0						TCACACGGTTCCACGGCTCCA	0.701													T	112738459	T	T	112738459	4	4	45	1	0	0	0	0	0	1	0	0	2210	856	30	3	1703	3	C3orf17	3	112738459	Nonsense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	48	112738459	85283971	22	2866											
IFT80	57560	broad.mit.edu	37	chr3	160075296	160075296	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttatatttacagtcttcaCcagcagataaaataagatca	4	9	3	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr3:160075296C>T	uc011boy.1	-	7	1053	c.620G>A	c.(619-621)GGT>GAT	p.G207D	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Missense_Mutation_p.G70D|IFT80_uc003fdd.1_Translation_Start_Site|IFT80_uc003fde.1_Missense_Mutation_p.G70D	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	207	WD 4.					cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ACAGTCTTCACCAGCAGATAA	0.264													T	160075296	T	T	160075296	3	4	45	1	0	0	0	0	1	0	0	0	7564	507	18	3	1769	3	IFT80	3	160075296	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	47336837	160075296	37947134	23	2867											
GPR125	166647	broad.mit.edu	37	chr4	22414939	22414939	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaatcccaccgggctgcaaCagcatctgctccatgtgcaa	9	14	1	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr4:22414939C>T	uc003gqm.1	-	14	2363	c.2098G>A	c.(2098-2100)GTT>ATT	p.V700I	GPR125_uc010ieo.1_Missense_Mutation_p.V556I	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	700	Extracellular (Potential).|GPS.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				CGGGCTGCAACAGCATCTGCT	0.443													T	22414939	T	T	22414939	3	4	45	1	0	0	0	0	1	0	0	0	6639	478	17	3	1891	3	GPR125	4	22414939	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08		22414939	168739337	24	2868											
PHOX2B	8929	broad.mit.edu	37	chr4	41748308	41748308	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgctgcgcgctcctgcttgCgaaacttggcgcggcggttc	14	15	0	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr4:41748308C>T	uc003gwf.3	-	3	821	c.461G>A	c.(460-462)CGC>CAC	p.R154H		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	154	Homeobox.				positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						CTCCTGCTTGCGAAACTTGGC	0.617			Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				T	41748308	T	T	41748308	3	4	45	1	0	0	0	0	1	0	0	0	11859	768	27	1	487	1	PHOX2B	4	41748308	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	19333369	41748308	149405968	25	2869											
PDGFRA	5156	broad.mit.edu	37	chr4	55131142	55131142	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaaccgtgtataagtcagggGaaacgattgtggtcacctgt	12	7	2	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr4:55131142G>A	uc003han.3	+	5	1016	c.685G>A	c.(685-687)GAA>AAA	p.E229K	PDGFRA_uc003haa.2_Intron|PDGFRA_uc003hal.2_3'UTR|PDGFRA_uc010igq.1_Missense_Mutation_p.E123K|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	229	Ig-like C2-type 3.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TAAGTCAGGGGAAACGATTGT	0.413			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			A	55131142	A	A	55131142	3	1	45	1	0	0	0	0	1	0	0	0	11661	1175	41	3	699	3	PDGFRA	4	55131142	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	13382834	55131142	136023134	26	2870											
SGMS2	166929	broad.mit.edu	37	chr4	108820833	108820833	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctgtgcctggaatgcatttCcagtgtgctccaaaggtcag	11	11	1	0	rs150340532		TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr4:108820833C>T	uc003hyl.3	+	4	1113	c.558C>T	c.(556-558)TTC>TTT	p.F186F	uc003hym.1_Intron|SGMS2_uc003hyn.2_Silent_p.F186F|SGMS2_uc003hyo.2_Silent_p.F186F	NM_001136258	NP_001129730	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	186					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			lung(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	GAATGCATTTCCAGTGTGCTC	0.398													T	108820833	T	T	108820833	2	4	45	1	0	0	0	0	0	0	0	1	14215	854	30	3		3	SGMS2	4	108820833	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08	53689691	108820833	82333443	27	2871											
AP1AR	55435	broad.mit.edu	37	chr4	113189433	113189433	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgattccaatgggctggaGtgggaaaatgattttgttag	14	3	0	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr4:113189433G>A	uc003iaj.3	+	10	1130	c.777G>A	c.(775-777)GAG>GAA	p.E259E	AP1AR_uc003iak.3_Silent_p.E226E	NM_018569	NP_061039	Q63HQ0	AP1AR_HUMAN	adaptor-related protein complex 1 associated	259					protein transport	early endosome|Golgi apparatus|late endosome|transport vesicle					0						ATGGGCTGGAGTGGGAAAATG	0.403													A	113189433	A	A	113189433	2	1	45	1	0	0	0	0	0	0	0	1	730	1020	36	3		3	AP1AR	4	113189433	Silent	SNP	G	TCGA-06-0214-01A-02D-1491-08	4368600	113189433	77964843	28	2872											
MAP3K1	4214	broad.mit.edu	37	chr5	56160697	56160697	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttactgcagcagatagggcCtaactctttcctgattggag	10	10	1	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr5:56160697C>T	uc003jqw.3	+	4	1472	c.971C>T	c.(970-972)CCT>CTT	p.P324L		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	324					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		CAGATAGGGCCTAACTCTTTC	0.468													T	56160697	T	T	56160697	3	4	45	1	0	0	0	0	1	0	0	0	9243	681	24	3	985	3	MAP3K1	5	56160697	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08		56160697	124754563	29	2873											
PAM	5066	broad.mit.edu	37	chr5	102284128	102284128	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttatgatgtctgttgacactGttatcccagcaggagaaaaa	9	7	1	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr5:102284128G>C	uc003knw.2	+	8	995	c.622G>C	c.(622-624)GTT>CTT	p.V208L	PAM_uc003kns.2_Missense_Mutation_p.V208L|PAM_uc003knt.2_Missense_Mutation_p.V208L|PAM_uc003knu.2_Missense_Mutation_p.V208L|PAM_uc003knv.2_Missense_Mutation_p.V208L|PAM_uc011cuz.1_Missense_Mutation_p.V111L	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	208	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).|Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	TGTTGACACTGTTATCCCAGC	0.303													C	102284128	C	C	102284128	3	2	45	1	0	0	0	0	1	0	0	0	11412	1377	48	5	652	5	PAM	5	102284128	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	46123431	102284128	78631132	30	2874											
KIF4B	285643	broad.mit.edu	37	chr5	154396823	154396823	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttgggcactgttgaacagaCccaggattccgaaggctcct	11	12	0	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr5:154396823C>A	uc010jih.1	+	1	3564	c.3404C>A	c.(3403-3405)ACC>AAC	p.T1135N		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1135	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTTGAACAGACCCAGGATTCC	0.537													A	154396823	A	A	154396823	3	1	45	1	0	0	0	0	1	0	0	0	8304	507	18	5	3406	5	KIF4B	5	154396823	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	52112695	154396823	26518437	31	2875											
GRM6	2916	broad.mit.edu	37	chr5	178416095	178416095	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatcacaaactgcaccttgcCctcctgctcgtaggtggagt	9	13	1	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr5:178416095C>T	uc003mjr.2	-	6	1374	c.1195G>A	c.(1195-1197)GGC>AGC	p.G399S	GRM6_uc010jla.1_Intron|GRM6_uc003mjs.1_Missense_Mutation_p.G19S	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	399	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TGCACCTTGCCCTCCTGCTCG	0.667													T	178416095	T	T	178416095	3	4	45	1	0	0	0	0	1	0	0	0	6801	623	22	3	1458	3	GRM6	5	178416095	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	24019272	178416095	2499165	32	2876											
DSP	1832	broad.mit.edu	37	chr6	7581804	7581804	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaagcaggctttagaggTattcacaaatacttgatcac	7	9	2	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr6:7581804T>A	uc003mxp.1	+	23	5658	c.5379_splice	c.e23+2	p.E1793_splice	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I						cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCTTTAGAGGTATTCACAAAT	0.373													A	7581804	A	A	7581804	5	1	45	1	0	0	0	0	0	0	1	0	4781	1652	57	5	5471	5	DSP	6	7581804	Splice_Site	SNP	T	TCGA-06-0214-01A-02D-1491-08		7581804	163533263	33	2877											
BTBD9	114781	broad.mit.edu	37	chr6	38224188	38224188	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaaaagacacaacttacttgCaggagactttagttctgtca	8	8	2	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr6:38224188C>A	uc003ooa.3	-	10	2135	c.1559G>T	c.(1558-1560)TGC>TTC	p.C520F	BTBD9_uc003ony.3_Missense_Mutation_p.C452F|BTBD9_uc010jwv.2_Missense_Mutation_p.C481F|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.C520F	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	520					cell adhesion						0						AACTTACTTGCAGGAGACTTT	0.408													A	38224188	A	A	38224188	3	1	45	1	0	0	0	0	1	0	0	0	1548	710	25	5	291	5	BTBD9	6	38224188	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	30642384	38224188	132890879	34	2878											
ABCA13	154664	broad.mit.edu	37	chr7	48312026	48312026	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagctctgaacacagtctaCgctatcaggaatgcatctga	9	10	4	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr7:48312026C>T	uc003toq.2	+	17	2788	c.2763C>T	c.(2761-2763)TAC>TAT	p.Y921Y	ABCA13_uc010kyr.2_Silent_p.Y424Y	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	921					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ACACAGTCTACGCTATCAGGA	0.378													T	48312026	T	T	48312026	2	4	45	1	0	0	0	0	0	0	0	1	31	547	19	1		1	ABCA13	7	48312026	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08		48312026	110826637	35	2879											
WBSCR17	64409	broad.mit.edu	37	chr7	70880884	70880884	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcatttgcagaggagctgaAggtccccctagaggagtatg	14	8	1	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr7:70880884A>G	uc003tvy.2	+	4	599	c.599A>G	c.(598-600)AAG>AGG	p.K200R	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	200	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GAGGAGCTGAAGGTCCCCCTA	0.498													G	70880884	G	G	70880884	3	3	45	1	0	0	0	0	1	0	0	0	17261	72	3	4	613	4	WBSCR17	7	70880884	Missense_Mutation	SNP	A	TCGA-06-0214-01A-02D-1491-08	22568858	70880884	88257779	36	2880											
PCLO	27445	broad.mit.edu	37	chr7	82581587	82581587	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgagatccactacttccccAtcagtgattccctgggatac	7	14	1	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr7:82581587A>G	uc003uhx.2	-	5	8971	c.8682T>C	c.(8680-8682)GAT>GAC	p.D2894D	PCLO_uc003uhv.2_Silent_p.D2894D|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2825					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTACTTCCCCATCAGTGATTC	0.438													G	82581587	G	G	82581587	2	3	45	1	0	0	0	0	0	0	0	1	11583	214	8	4		4	PCLO	7	82581587	Silent	SNP	A	TCGA-06-0214-01A-02D-1491-08	11700703	82581587	76557076	37	2881											
ZCWPW1	55063	broad.mit.edu	37	chr7	100017491	100017491	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtggggcaaagattctctttGgtccctttccacattctgaa	9	10	2	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr7:100017491G>C	uc003uut.2	-	4	292	c.44C>G	c.(43-45)CCA>CGA	p.P15R	ZCWPW1_uc011kjq.1_5'Flank|ZCWPW1_uc003uur.2_5'Flank|ZCWPW1_uc003uus.2_5'UTR|ZCWPW1_uc011kjr.1_Missense_Mutation_p.P14R|ZCWPW1_uc003uuu.1_Missense_Mutation_p.P14R|ZCWPW1_uc011kjs.1_5'Flank|ZCWPW1_uc011kjt.1_Missense_Mutation_p.P14R|ZCWPW1_uc011kju.1_Missense_Mutation_p.P14R	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	15							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GATTCTCTTTGGTCCCTTTCC	0.413													C	100017491	C	C	100017491	3	2	45	1	0	0	0	0	1	0	0	0	17594	1348	47	5	1962	5	ZCWPW1	7	100017491	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	17435904	100017491	59121172	38	2882											
FOXP2	93986	broad.mit.edu	37	chr7	114304409	114304409	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtggcctactgcaggccGtccacgaagacctcaatggt	11	14	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr7:114304409G>A	uc003vhb.2	+	16	2295	c.1921G>A	c.(1921-1923)GTC>ATC	p.V641I	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.V666I|FOXP2_uc003vha.2_Missense_Mutation_p.V549I|FOXP2_uc011kmu.1_Missense_Mutation_p.V658I|FOXP2_uc011kmv.1_Missense_Mutation_p.V640I|FOXP2_uc010ljz.1_Missense_Mutation_p.V456I	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	641					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						ACTGCAGGCCGTCCACGAAGA	0.483													A	114304409	A	A	114304409	3	1	45	1	0	0	0	0	1	0	0	0	6027	1145	40	1	2146	1	FOXP2	7	114304409	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	14286918	114304409	44834254	39	2883											
TES	26136	broad.mit.edu	37	chr7	115889085	115889085	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaattatagaaaaatatgtcGtaactgcaagtgtggccaag	9	5	0	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr7:115889085G>A	uc003vho.2	+	3	306	c.125G>A	c.(124-126)CGT>CAT	p.R42H	TES_uc011kmx.1_Missense_Mutation_p.R42H|TES_uc011kmy.1_Intron|TES_uc010lka.1_Missense_Mutation_p.R33H|TES_uc003vhp.2_Missense_Mutation_p.R33H	NM_015641	NP_056456	Q9UGI8	TES_HUMAN	testin isoform 1	42	Cys-rich.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding				0	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			AAAATATGTCGTAACTGCAAG	0.313													A	115889085	A	A	115889085	3	1	45	1	0	0	0	0	1	0	0	0	15762	1145	40	1	135	1	TES	7	115889085	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	1584676	115889085	43249578	40	2884											
WDR91	29062	broad.mit.edu	37	chr7	134878049	134878049	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acctggttcatgcccttgctGccgatgtctggtgctgagaa	12	11	2	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr7:134878049G>T	uc003vsp.2	-	11	1655	c.1593C>A	c.(1591-1593)GGC>GGA	p.G531G	WDR91_uc010lmq.2_Silent_p.G120G|WDR91_uc010lmr.2_RNA	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	531	WD 3.									breast(2)|ovary(1)|skin(1)	4						TGCCCTTGCTGCCGATGTCTG	0.622													T	134878049	T	T	134878049	2	4	45	1	0	0	0	0	0	0	0	1	17335	1306	46	5		5	WDR91	7	134878049	Silent	SNP	G	TCGA-06-0214-01A-02D-1491-08	18988964	134878049	24260614	41	2885											
HTR5A	3361	broad.mit.edu	37	chr7	154863097	154863097	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtctccaacgtcatgatcgCgctcacctgggcactctccg	9	17	4	1	rs150537072	byFrequency	TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr7:154863097C>T	uc003wlu.1	+	1	552	c.488C>T	c.(487-489)GCG>GTG	p.A163V	uc011kvt.1_5'UTR|uc003wlt.2_5'UTR	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	163	Helical; Name=4; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GTCATGATCGCGCTCACCTGG	0.627													T	154863097	T	T	154863097	3	4	45	1	0	0	0	0	1	0	0	0	7450	768	27	1	490	1	HTR5A	7	154863097	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	19985048	154863097	4275566	42	2886											
PTK2B	2185	broad.mit.edu	37	chr8	27310672	27310672	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagcccccgaggctgggcGcacaggtatgtgttggctct	15	11	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr8:27310672G>A	uc003xfn.1	+	33	3398	c.2590G>A	c.(2590-2592)GCA>ACA	p.A864T	PTK2B_uc003xfo.1_Missense_Mutation_p.A864T|PTK2B_uc003xfp.1_Missense_Mutation_p.A864T|PTK2B_uc003xfq.1_Missense_Mutation_p.A822T	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	864	Interaction with TGFB1I1 (By similarity).|Pro-rich.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		GAGGCTGGGCGCACAGGTATG	0.498													A	27310672	A	A	27310672	3	1	45	1	0	0	0	0	1	0	0	0	12763	1087	38	1	2696	1	PTK2B	8	27310672	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08		27310672	119053350	43	2887											
TEX15	56154	broad.mit.edu	37	chr8	30705979	30705979	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttttgtataagcattaccGgactcctgttgggctctctg	9	10	2	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr8:30705979G>A	uc003xil.2	-	1	555	c.555C>T	c.(553-555)TCC>TCT	p.S185S		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	185										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AAGCATTACCGGACTCCTGTT	0.413													A	30705979	A	A	30705979	2	1	45	1	0	0	0	0	0	0	0	1	15776	1103	39	2		2	TEX15	8	30705979	Silent	SNP	G	TCGA-06-0214-01A-02D-1491-08	3395307	30705979	115658043	44	2888											
RRAGA	10670	broad.mit.edu	37	chr9	19050150	19050150	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cttgttttcgaacgtccatcTgggatgagacgctctacaaa	9	10	2	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr9:19050150T>A	uc003znj.2	+	1	779	c.493T>A	c.(493-495)TGG>AGG	p.W165R		NM_006570	NP_006561	Q7L523	RRAGA_HUMAN	Ras-related GTP binding A	165					apoptosis|cellular protein localization|cellular response to amino acid stimulus|positive regulation of cytolysis|positive regulation of TOR signaling cascade|virus-host interaction	Golgi apparatus|lysosome|nucleus	GTP binding|phosphoprotein binding|protein heterodimerization activity|protein homodimerization activity				0						AACGTCCATCTGGGATGAGAC	0.522													A	19050150	A	A	19050150	3	1	45	1	0	0	0	0	1	0	0	0	13672	1580	55	5	495	5	RRAGA	9	19050150	Missense_Mutation	SNP	T	TCGA-06-0214-01A-02D-1491-08		19050150	122163281	45	2889											
CCL19	6363	broad.mit.edu	37	chr9	34690006	34690006	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcacagagctggcggcccCtcagtgtggtgaacctgggg	17	11	1	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr9:34690006C>T	uc003zvn.2	-	3	335	c.197G>A	c.(196-198)AGG>AAG	p.R66K	CCL19_uc010mkf.2_Intron	NM_006274	NP_006265	Q99731	CCL19_HUMAN	small inducible cytokine A19 precursor	66					activation of JUN kinase activity|cell communication|cell maturation|establishment of T cell polarity|immune response|immunological synapse formation|inflammatory response|interleukin-12 secretion|myeloid dendritic cell chemotaxis|negative regulation of leukocyte apoptosis|positive regulation of Cdc42 GTPase activity|positive regulation of dendritic cell antigen processing and presentation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glycoprotein biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of neutrophil chemotaxis|positive regulation of NF-kappaB import into nucleus|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of receptor-mediated endocytosis|positive regulation of T cell proliferation|positive regulation of T-helper 1 cell differentiation|positive regulation of tumor necrosis factor production|regulation of cell projection assembly|release of sequestered calcium ion into cytosol|response to nitric oxide|response to prostaglandin E stimulus|response to virus|T cell costimulation	extracellular space	CCR10 chemokine receptor binding|CCR7 chemokine receptor binding|chemokine activity				0	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		CTGGCGGCCCCTCAGTGTGGT	0.622													T	34690006	T	T	34690006	3	4	45	1	0	0	0	0	1	0	0	0	2890	681	24	3	107	3	CCL19	9	34690006	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	15639856	34690006	106523425	46	2890											
PAX5	5079	broad.mit.edu	37	chr9	36846902	36846902	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggaatactgagggtggctgTagggactcccggaaaactca	14	8	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr9:36846902T>C	uc003zzo.1	-	9	1485	c.1037A>G	c.(1036-1038)TAC>TGC	p.Y346C	PAX5_uc011lpt.1_Missense_Mutation_p.Y142C|PAX5_uc011lpu.1_RNA|PAX5_uc011lpv.1_Intron|PAX5_uc011lpw.1_Intron|PAX5_uc011lpx.1_Missense_Mutation_p.Y246C|PAX5_uc011lpy.1_Intron|PAX5_uc010mls.1_Intron|PAX5_uc011lpz.1_Missense_Mutation_p.Y303C|PAX5_uc011lqa.1_Missense_Mutation_p.Y238C|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.Y312C|PAX5_uc010mlp.1_Intron|PAX5_uc011lqc.1_Intron|PAX5_uc010mlr.1_Missense_Mutation_p.T269A	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	346					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(11)|p.Y346C(1)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		AGGGTGGCTGTAGGGACTCCC	0.597			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								C	36846902	C	C	36846902	3	2	45	1	0	0	0	0	1	0	0	0	11482	1638	57	4	146	4	PAX5	9	36846902	Missense_Mutation	SNP	T	TCGA-06-0214-01A-02D-1491-08	2156896	36846902	104366529	47	2891											
RAD23B	5887	broad.mit.edu	37	chr9	110084309	110084309	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aggctgtggttgacccccctCaagcagctagtactggggct	13	12	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr9:110084309C>T	uc004bde.2	+	7	1094	c.727C>T	c.(727-729)CAA>TAA	p.Q243*	RAD23B_uc011lwa.1_Nonsense_Mutation_p.Q243*|RAD23B_uc011lwb.1_Nonsense_Mutation_p.Q222*	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	243					nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						TGACCCCCCTCAAGCAGCTAG	0.458								Direct_reversal_of_damage|NER					T	110084309	T	T	110084309	4	4	45	1	0	0	0	0	0	1	0	0	12983	827	29	3	753	3	RAD23B	9	110084309	Nonsense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	73237407	110084309	31129122	48	2892											
C9orf91	203197	broad.mit.edu	37	chr9	117396107	117396107	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagccctcctgagacaccgGgtgctgctgggggtgacaga	17	11	0	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr9:117396107G>A	uc004bjd.3	+	6	751	c.534G>A	c.(532-534)CGG>CGA	p.R178R	C9orf91_uc004bje.3_Silent_p.R157R|C9orf91_uc004bjf.3_Silent_p.R77R	NM_153045	NP_694590	Q5VZI3	CI091_HUMAN	hypothetical protein LOC203197	178						integral to membrane				pancreas(1)	1						TGAGACACCGGGTGCTGCTGG	0.567													A	117396107	A	A	117396107	2	1	45	1	0	0	0	0	0	0	0	1	2505	1219	43	3		3	C9orf91	9	117396107	Silent	SNP	G	TCGA-06-0214-01A-02D-1491-08	7311798	117396107	23817324	49	2893											
SEC16A	9919	broad.mit.edu	37	chr9	139358176	139358176	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatctcctcctgctcagacGtgtgctgcagcaaggcctac	10	15	2	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr9:139358176G>A	uc004chx.2	-	10	4772	c.4463C>T	c.(4462-4464)ACG>ATG	p.T1488M	SEC16A_uc004chv.3_Missense_Mutation_p.T878M|SEC16A_uc004chw.2_Missense_Mutation_p.T1488M|SEC16A_uc010nbn.2_Missense_Mutation_p.T1488M	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1310					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CTGCTCAGACGTGTGCTGCAG	0.647													A	139358176	A	A	139358176	3	1	45	1	0	0	0	0	1	0	0	0	13986	1145	40	1	2702	1	SEC16A	9	139358176	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	21962069	139358176	1855255	50	2894											
PLXDC2	84898	broad.mit.edu	37	chr10	20466312	20466312	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcttctcagattggcttcaaCtgcagttggtgtagtaaact	9	8	3	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr10:20466312C>G	uc001iqg.1	+	9	1672	c.1035C>G	c.(1033-1035)AAC>AAG	p.N345K	PLXDC2_uc001iqh.1_Missense_Mutation_p.N296K|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	345	Extracellular (Potential).|PSI.					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TTGGCTTCAACTGCAGTTGGT	0.294													G	20466312	G	G	20466312	3	3	45	1	0	0	0	0	1	0	0	0	12118	564	20	5	1069	5	PLXDC2	10	20466312	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08		20466312	115068435	51	2895											
OR4X2	119764	broad.mit.edu	37	chr11	48266683	48266683	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aattcatttttctggtacttTctcccaaccaggaggtgcag	8	10	3	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr11:48266683T>C	uc001ngs.1	+	1	28	c.28T>C	c.(28-30)TCT>CCT	p.S10P		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTGGTACTTTCTCCCAACCA	0.423													C	48266683	C	C	48266683	3	2	45	1	0	0	0	0	1	0	0	0	11085	1783	62	4	30	4	OR4X2	11	48266683	Missense_Mutation	SNP	T	TCGA-06-0214-01A-02D-1491-08		48266683	86739833	52	2896											
LRRC55	219527	broad.mit.edu	37	chr11	56950158	56950158	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatccagcgctgtacagcagGtaatagaggggcagaacggg	16	8	0	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr11:56950158G>A	uc001njl.1	+	1	937	c.790_splice	c.e1+1	p.D264_splice		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55							integral to membrane					0						TGTACAGCAGGTAATAGAGGG	0.587													A	56950158	A	A	56950158	5	1	45	1	0	0	0	0	0	0	1	0	9011	1275	44	3	793	3	LRRC55	11	56950158	Splice_Site	SNP	G	TCGA-06-0214-01A-02D-1491-08	8683475	56950158	78056358	53	2897											
APLNR	187	broad.mit.edu	37	chr11	57003536	57003536	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgcaggcctggcggaagcGggggtcgaaaaaggcataga	19	7	0	1	rs137997556		TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr11:57003536G>A	uc001njo.2	-	1	1392	c.943C>T	c.(943-945)CGC>TGC	p.R315C	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	315	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						TGGCGGAAGCGGGGGTCGAAA	0.587													A	57003536	A	A	57003536	3	1	45	1	0	0	0	0	1	0	0	0	777	1116	39	2	203	2	APLNR	11	57003536	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	53378	57003536	78002980	54	2898											
SMTNL1	219537	broad.mit.edu	37	chr11	57310651	57310651	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacagcctctcaggaggagaCaggccagaggaaagagtgca	15	9	1	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr11:57310651C>T	uc009ymh.1	+	2	590	c.590C>T	c.(589-591)ACA>ATA	p.T197I		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	179										ovary(1)	1						CAGGAGGAGACAGGCCAGAGG	0.547													T	57310651	T	T	57310651	3	4	45	1	0	0	0	0	1	0	0	0	14815	478	17	3	596	3	SMTNL1	11	57310651	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	307115	57310651	77695865	55	2899											
CD248	57124	broad.mit.edu	37	chr11	66082764	66082764	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gataatgggaagctgggtggCctgggttctgaggacaaggg	19	5	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr11:66082764C>T	uc001ohm.1	-	1	1752	c.1735G>A	c.(1735-1737)GCC>ACC	p.A579T		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	579	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	AGCTGGGTGGCCTGGGTTCTG	0.612													T	66082764	T	T	66082764	3	4	45	1	0	0	0	0	1	0	0	0	2989	739	26	3	542	3	CD248	11	66082764	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	8772113	66082764	68923752	56	2900											
C12orf57	113246	broad.mit.edu	37	chr12	7054965	7054965	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgctcgcttggtcaagtcCtacgaagcccaggatcctga	10	12	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr12:7054965C>T	uc001qrz.2	+	3	343	c.261C>T	c.(259-261)TCC>TCT	p.S87S	PTPN6_uc001qsa.1_5'Flank|PTPN6_uc010sfr.1_5'Flank	NM_138425	NP_612434	Q99622	C10_HUMAN	C10 protein	87											0						TGGTCAAGTCCTACGAAGCCC	0.602													T	7054965	T	T	7054965	2	4	45	1	0	0	0	0	0	0	0	1	1701	668	24	3		3	C12orf57	12	7054965	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08		7054965	126796930	57	2901											
ACSM4	341392	broad.mit.edu	37	chr12	7469737	7469737	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtccatattttgcagattcGcctctgaagagcacagctgt	10	10	1	3	rs139422294	by1000genomes	TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr12:7469737G>A	uc001qsx.1	+	4	625	c.625G>A	c.(625-627)GCC>ACC	p.A209T		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	209					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						TTGCAGATTCGCCTCTGAAGA	0.483													A	7469737	A	A	7469737	3	1	45	1	0	0	0	0	1	0	0	0	186	1087	38	1	639	1	ACSM4	12	7469737	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	414772	7469737	126382158	58	2902											
TM7SF3	51768	broad.mit.edu	37	chr12	27127064	27127064	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgcttccataacttgtatGggtggggagggaagaacggt	15	6	0	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr12:27127064G>A	uc010sjl.1	-	12	1785	c.1547C>T	c.(1546-1548)CCA>CTA	p.P516L		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	516						integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					TAACTTGTATGGGTGGGGAGG	0.493													A	27127064	A	A	27127064	3	1	45	1	0	0	0	0	1	0	0	0	15972	1348	47	3	169	3	TM7SF3	12	27127064	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	19657327	27127064	106724831	59	2903											
DIP2B	57609	broad.mit.edu	37	chr12	51122397	51122397	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agtgtgagttgtactcttctCggcagatcgccatctgcctt	10	11	3	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr12:51122397C>T	uc001rwv.2	+	30	3733	c.3577C>T	c.(3577-3579)CGG>TGG	p.R1193W	DIP2B_uc009zlt.2_Missense_Mutation_p.R623W	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1193						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GTACTCTTCTCGGCAGATCGC	0.532													T	51122397	T	T	51122397	3	4	45	1	0	0	0	0	1	0	0	0	4528	875	31	2	3695	2	DIP2B	12	51122397	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	23995333	51122397	82729498	60	2904											
ACACB	32	broad.mit.edu	37	chr12	109680275	109680275	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccttcggcaacaagcaagggCcccagcacgggatgctgatc	12	14	0	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr12:109680275C>G	uc001tob.2	+	37	5175	c.5056C>G	c.(5056-5058)CCC>GCC	p.P1686A	ACACB_uc001toc.2_Missense_Mutation_p.P1686A|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.P352A	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1686					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CAAGCAAGGGCCCCAGCACGG	0.522													G	109680275	G	G	109680275	3	3	45	1	0	0	0	0	1	0	0	0	107	739	26	5	5198	5	ACACB	12	109680275	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	58557878	109680275	24171620	61	2905											
KSR2	283455	broad.mit.edu	37	chr12	118298128	118298128	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgcgcacatcgacgattcGgaaccagtgccgtagctggg	13	12	0	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr12:118298128G>A	uc001two.2	-	2	257	c.202C>T	c.(202-204)CGA>TGA	p.R68*		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	97					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCGACGATTCGGAACCAGTGC	0.627													A	118298128	A	A	118298128	4	1	45	1	0	0	0	0	0	1	0	0	8582	1124	39	2	2639	2	KSR2	12	118298128	Nonsense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	8617853	118298128	15553767	62	2906											
RBM25	58517	broad.mit.edu	37	chr14	73569957	73569957	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacaggaaattgagaaagaaCggagagaaagagagagggag	17	2	0	5			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr14:73569957C>T	uc001xno.2	+	10	1133	c.925C>T	c.(925-927)CGG>TGG	p.R309W	RBM25_uc010ttu.1_Missense_Mutation_p.R309W|RBM25_uc001xnp.2_Missense_Mutation_p.R104W	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	309	Necessary for nuclear speckle localization.|Glu-rich.|Arg-rich.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		tgagaaagaacggagagaaag	0.085													T	73569957	T	T	73569957	3	4	45	1	0	0	0	0	1	0	0	0	13125	527	19	1	959	1	RBM25	14	73569957	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08		73569957	33779583	63	2907											
MKRN3	7681	broad.mit.edu	37	chr15	23811493	23811493	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgagagagacaatgcagaCcgtggagctgctggaggagc	17	9	0	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr15:23811493C>T	uc001ywh.3	+	1	1040	c.564C>T	c.(562-564)GAC>GAT	p.D188D	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Silent_p.D188D	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	188						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		ACAATGCAGACCGTGGAGCTG	0.617													T	23811493	T	T	23811493	2	4	45	1	0	0	0	0	0	0	0	1	9608	506	18	3		3	MKRN3	15	23811493	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08		23811493	78719899	64	2908											
GABRA5	2558	broad.mit.edu	37	chr15	27193227	27193227	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaaccctctgaagagaagacTtctgaaagcaaaaagactta	7	8	2	5			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr15:27193227T>A	uc001zbd.1	+	12	1575	c.1236T>A	c.(1234-1236)ACT>ACA	p.T412T	GABRA5_uc001zbe.1_RNA	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	412	Cytoplasmic (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAGAGAAGACTTCTGAAAGCA	0.453													A	27193227	A	A	27193227	2	1	45	1	0	0	0	0	0	0	0	1	6164	1596	56	5		5	GABRA5	15	27193227	Silent	SNP	T	TCGA-06-0214-01A-02D-1491-08	3381734	27193227	75338165	65	2909											
DNAJA4	55466	broad.mit.edu	37	chr15	78567950	78567950	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	agaaggatcatagtgtctttCagagacgaggccatgacttg	12	7	3	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr15:78567950C>G	uc002bdj.1	+	5	874	c.757C>G	c.(757-759)CAG>GAG	p.Q253E	DNAJA4_uc002bdi.2_Missense_Mutation_p.Q282E|DNAJA4_uc002bdk.2_Missense_Mutation_p.Q226E|DNAJA4_uc002bdm.1_Missense_Mutation_p.Q37E	NM_001130182	NP_001123654	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	253					protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			skin(1)	1						TAGTGTCTTTCAGAGACGAGG	0.413													G	78567950	G	G	78567950	3	3	45	1	0	0	0	0	1	0	0	0	4614	827	29	5	921	5	DNAJA4	15	78567950	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	51374723	78567950	23963442	66	2910											
LRRC28	123355	broad.mit.edu	37	chr15	99901711	99901711	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcatacctaccacagcttgcTgaaaggtacgtgggacttct	9	11	2	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr15:99901711T>A	uc002bva.1	+	8	1021	c.866T>A	c.(865-867)CTG>CAG	p.L289Q	LRRC28_uc010urs.1_RNA|LRRC28_uc002bvb.1_Missense_Mutation_p.L135Q|LRRC28_uc010urt.1_Missense_Mutation_p.L103Q|LRRC28_uc002bvc.1_Missense_Mutation_p.L289Q|LRRC28_uc010uru.1_Missense_Mutation_p.L220Q|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	289											0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			CACAGCTTGCTGAAAGGTACG	0.458											OREG0023509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	99901711	A	A	99901711	3	1	45	1	0	0	0	0	1	0	0	0	8982	1580	55	5	892	5	LRRC28	15	99901711	Missense_Mutation	SNP	T	TCGA-06-0214-01A-02D-1491-08	21333761	99901711	2629681	67	2911											
RBBP6	5930	broad.mit.edu	37	chr16	24583037	24583037	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatcacaaagccacttatgaTactaaacggccaaatgaaga	7	9	1	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr16:24583037T>C	uc002dmh.2	+	18	5690	c.4650T>C	c.(4648-4650)GAT>GAC	p.D1550D	RBBP6_uc002dmi.2_Silent_p.D1516D|RBBP6_uc010bxr.2_Silent_p.D710D|RBBP6_uc002dmk.2_Silent_p.D1383D	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1550					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		CCACTTATGATACTAAACGGC	0.363													C	24583037	C	C	24583037	2	2	45	1	0	0	0	0	0	0	0	1	13103	1403	49	4		4	RBBP6	16	24583037	Silent	SNP	T	TCGA-06-0214-01A-02D-1491-08		24583037	65771716	68	2912											
PITPNA	5306	broad.mit.edu	37	chr17	1456417	1456417	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatttttactggcctcagcCacagaatacagctgccccac	6	15	2	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr17:1456417C>T	uc002fst.3	-	3	334	c.78G>A	c.(76-78)GTG>GTA	p.V26V	PITPNA_uc010cjt.2_5'UTR|PITPNA_uc010cju.2_5'UTR|PITPNA_uc010vqn.1_RNA	NM_006224	NP_006215	Q00169	PIPNA_HUMAN	phosphatidylinositol transfer protein, alpha	26					axon guidance|lipid metabolic process|visual perception	cytoplasm	phosphatidylcholine transmembrane transporter activity|phosphatidylinositol transporter activity|protein binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0845)		TGGCCTCAGCCACAGAATACA	0.512													T	1456417	T	T	1456417	2	4	45	1	0	0	0	0	0	0	0	1	11947	581	21	3		3	PITPNA	17	1456417	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08		1456417	79738793	69	2913											
SLC47A1	55244	broad.mit.edu	37	chr17	19459334	19459334	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcggcatggtggagctgggcGctcagtccatcgtgtatgaa	15	9	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr17:19459334G>A	uc002gvy.1	+	10	966	c.880G>A	c.(880-882)GCT>ACT	p.A294T	SLC47A1_uc010vyy.1_RNA|SLC47A1_uc002gvx.2_Missense_Mutation_p.A294T|SLC47A1_uc010vyz.1_Missense_Mutation_p.A271T|SLC47A1_uc010cqp.1_Intron|SLC47A1_uc010cqq.1_Missense_Mutation_p.A99T|SLC47A1_uc010vza.1_Missense_Mutation_p.A6T|SLC47A1_uc010vzb.1_Missense_Mutation_p.A28T|SLC47A1_uc010vzc.1_5'UTR|SNORA59B_uc002gvz.1_5'Flank	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	294	Extracellular (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					GGAGCTGGGCGCTCAGTCCAT	0.582													A	19459334	A	A	19459334	3	1	45	1	0	0	0	0	1	0	0	0	14647	1087	38	1	918	1	SLC47A1	17	19459334	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	18002917	19459334	61735876	70	2914											
KSR1	8844	broad.mit.edu	37	chr17	25909866	25909866	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctgcccgcctcagactccCccacccccagcttcagtgag	7	21	3	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr17:25909866C>T	uc010crg.2	+	5	749	c.304C>T	c.(304-306)CCC>TCC	p.P102S	KSR1_uc002gzj.1_Intron	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	237					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CTCAGACTCCCCCACCCCCAG	0.706													T	25909866	T	T	25909866	3	4	45	1	0	0	0	0	1	0	0	0	8581	623	22	3	310	3	KSR1	17	25909866	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	6450532	25909866	55285344	71	2915											
NF1	4763	broad.mit.edu	37	chr17	29654793	29654793	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	acaccaagattcggccaaaaGatgtccctgggacactgctc	9	13	0	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr17:29654793G>A	uc002hgg.2	+	38	5878	c.5545G>A	c.(5545-5547)GAT>AAT	p.D1849N	NF1_uc002hgh.2_Missense_Mutation_p.D1828N|NF1_uc002hgi.1_Missense_Mutation_p.D861N|NF1_uc010cso.2_Missense_Mutation_p.D37N	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1849					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.D1849N(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCGGCCAAAAGATGTCCCTGG	0.468			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29654793	A	A	29654793	3	1	45	1	0	0	0	0	1	0	0	0	10356	942	33	3	5756	3	NF1	17	29654793	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	3744927	29654793	51540417	72	2916											
CALCOCO2	10241	broad.mit.edu	37	chr17	46937756	46937756	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgtatcaagtacctacttcAgatgaaggaggcgcaagaca	10	10	2	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr17:46937756A>G	uc002iof.2	+	11	1168	c.1089A>G	c.(1087-1089)TCA>TCG	p.S363S	CALCOCO2_uc010wlp.1_Silent_p.S384S|CALCOCO2_uc010wlq.1_Silent_p.S291S|CALCOCO2_uc010wlr.1_Silent_p.S387S|CALCOCO2_uc010wls.1_Silent_p.S321S	NM_005831	NP_005822	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	363					response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			ovary(1)	1						TACCTACTTCAGATGAAGGAG	0.438													G	46937756	G	G	46937756	2	3	45	1	0	0	0	0	0	0	0	1	2578	175	7	4		4	CALCOCO2	17	46937756	Silent	SNP	A	TCGA-06-0214-01A-02D-1491-08	17282963	46937756	34257454	73	2917											
ACE	1636	broad.mit.edu	37	chr17	61560492	61560492	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggggggtctttagtgggcGtacccccccttcccgctaca	12	15	1	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr17:61560492G>A	uc002jau.1	+	9	1467	c.1445G>A	c.(1444-1446)CGT>CAT	p.R482H	ACE_uc010wpi.1_Intron|ACE_uc010ddu.1_Missense_Mutation_p.R299H|ACE_uc002jav.1_5'Flank|ACE_uc010ddv.1_5'Flank|ACE_uc010wpj.1_5'Flank|ACE_uc002jaw.1_5'Flank|ACE_uc010wpk.1_5'Flank	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	482	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TTTAGTGGGCGTACCCCCCCT	0.552													A	61560492	A	A	61560492	3	1	45	1	0	0	0	0	1	0	0	0	136	1145	40	1	1479	1	ACE	17	61560492	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	14622736	61560492	19634718	74	2918											
SLC38A10	124565	broad.mit.edu	37	chr17	79220094	79220094	+	Silent	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tgcccagggaattcctctgcGaggcgctcctctgggccccc	12	17	2	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr17:79220094G>C	uc002jzz.1	-	16	2997	c.2622C>G	c.(2620-2622)CTC>CTG	p.L874L	SLC38A10_uc002jzy.1_Silent_p.L792L	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	874					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ATTCCTCTGCGAGGCGCTCCT	0.657													C	79220094	C	C	79220094	2	2	45	1	0	0	0	0	0	0	0	1	14602	1045	37	5		5	SLC38A10	17	79220094	Silent	SNP	G	TCGA-06-0214-01A-02D-1491-08	17659602	79220094	1975116	75	2919											
DLGAP1	9229	broad.mit.edu	37	chr18	3534543	3534543	+	Frame_Shift_Del	DEL	G	-	-													agattccagagaattttccaGattatcatggaagtccaggt							TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr18:3534543delG	uc002kmf.2	-	7	2195	c.2128delC	c.(2128-2130)CTGfs	p.L710fs	DLGAP1_uc010wyz.1_Frame_Shift_Del_p.L710fs|DLGAP1_uc002kme.1_Frame_Shift_Del_p.L408fs|DLGAP1_uc010dkn.2_Frame_Shift_Del_p.L418fs|DLGAP1_uc010wyw.1_Frame_Shift_Del_p.L416fs|DLGAP1_uc010wyx.1_Frame_Shift_Del_p.L432fs|DLGAP1_uc010wyy.1_Frame_Shift_Del_p.L394fs|DLGAP1_uc002kmg.2_Frame_Shift_Del_p.L408fs	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	710					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GAATTTTCCAGATTATCATGG	0.498													-	3534543	-	-	3534543	7	5	45	1	0	1	0	1	0	0	0	0	4559	933	33	0	821	0	DLGAP1	18	3534543	Frame_Shift_Del	DEL	G	TCGA-06-0214-01A-02D-1491-08		3534543	74542705	76	2920											
NAPG	8774	broad.mit.edu	37	chr18	10548993	10548993	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcaatggcagtgaagactGtgctgccctggaacagcttc	12	10	1	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr18:10548993G>A	uc002kon.2	+	11	922	c.695G>A	c.(694-696)TGT>TAT	p.C232Y	NAPG_uc010wzr.1_Missense_Mutation_p.C150Y|NAPG_uc002koo.2_Missense_Mutation_p.C145Y|NAPG_uc002kop.2_Missense_Mutation_p.C145Y	NM_003826	NP_003817	Q99747	SNAG_HUMAN	N-ethylmaleimide-sensitive factor attachment	232					cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding				0						AGTGAAGACTGTGCTGCCCTG	0.418													A	10548993	A	A	10548993	3	1	45	1	0	0	0	0	1	0	0	0	10164	1377	48	3	737	3	NAPG	18	10548993	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	7014450	10548993	67528255	77	2921											
MUC16	94025	broad.mit.edu	37	chr19	9048365	9048365	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgataccccaggtgaaacaGttggagttggaacagctgag	13	8	0	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr19:9048365G>T	uc002mkp.2	-	5	33470	c.33266C>A	c.(33265-33267)ACT>AAT	p.T11089N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11091	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTGAAACAGTTGGAGTTGG	0.488													T	9048365	T	T	9048365	3	4	45	1	0	0	0	0	1	0	0	0	9973	1029	36	5	10577	5	MUC16	19	9048365	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08		9048365	50080618	78	2922											
NFIX	4784	broad.mit.edu	37	chr19	13201118	13201118	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctgctccccacagcattcGcaacgacaggcgcctcctct	7	20	1	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr19:13201118G>A	uc010xmx.1	+	10	1485	c.1432G>A	c.(1432-1434)GCA>ACA	p.A478T	NFIX_uc002mwd.2_Silent_p.S420S|NFIX_uc002mwe.2_Silent_p.S412S|NFIX_uc002mwf.2_Silent_p.S382S|NFIX_uc002mwg.1_Silent_p.S419S			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	470					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			CACAGCATTCGCAACGACAGG	0.642													A	13201118	A	A	13201118	3	1	45	1	0	0	0	0	1	0	0	0	10374	1074	38	1	1294	1	NFIX	19	13201118	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08	4152753	13201118	45927865	79	2923											
CCDC105	126402	broad.mit.edu	37	chr19	15132653	15132653	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttcacctggagaccgcagaAaagctggacagacccctggt	12	12	1	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr19:15132653A>G	uc002nae.2	+	6	1272	c.1173A>G	c.(1171-1173)GAA>GAG	p.E391E		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	391					microtubule cytoskeleton organization	microtubule				ovary(1)	1						AGACCGCAGAAAAGCTGGACA	0.647													G	15132653	G	G	15132653	2	3	45	1	0	0	0	0	0	0	0	1	2740	11	1	4		4	CCDC105	19	15132653	Silent	SNP	A	TCGA-06-0214-01A-02D-1491-08	1931535	15132653	43996330	80	2924											
CLPTM1	1209	broad.mit.edu	37	chr19	45494188	45494188	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgtatatcgagtcctcgacCaaagtgtatgatgatgtgag	11	7	0	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr19:45494188C>T	uc002pai.2	+	11	1419	c.1404C>T	c.(1402-1404)ACC>ACT	p.T468T	CLPTM1_uc010xxf.1_Silent_p.T366T|CLPTM1_uc010xxg.1_Silent_p.T454T	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	468	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		AGTCCTCGACCAAAGTGTATG	0.607													T	45494188	T	T	45494188	2	4	45	1	0	0	0	0	0	0	0	1	3554	581	21	3		3	CLPTM1	19	45494188	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08	30361535	45494188	13634795	81	2925											
ERCC1	2067	broad.mit.edu	37	chr19	45923654	45923654	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgccaaattcccagggcacaTtgcgcacgaacttcagtacg	9	14	1	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr19:45923654T>C	uc002pbs.1	-	4	499	c.353A>G	c.(352-354)AAT>AGT	p.N118S	ERCC1_uc002pbt.1_Missense_Mutation_p.N118S|ERCC1_uc002pbu.1_Missense_Mutation_p.N46S|ERCC1_uc002pbv.2_Missense_Mutation_p.N118S	NM_001983	NP_001974	P07992	ERCC1_HUMAN	excision repair cross-complementing 1 isofrom 2	118					mitotic recombination|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to oxidative stress|transcription-coupled nucleotide-excision repair	cytoplasm|nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair complex	damaged DNA binding|endonuclease activity|protein C-terminus binding|protein domain specific binding|single-stranded DNA binding			ovary(2)	2		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0247)		CCAGGGCACATTGCGCACGAA	0.562								NER					C	45923654	C	C	45923654	3	2	45	1	0	0	0	0	1	0	0	0	5212	1493	52	4	697	4	ERCC1	19	45923654	Missense_Mutation	SNP	T	TCGA-06-0214-01A-02D-1491-08	429466	45923654	13205329	82	2926											
PRR12	57479	broad.mit.edu	37	chr19	50099367	50099367	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ccctggcaaatacctgagctCagtcttggcctcagcgcctt	9	15	3	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr19:50099367C>T	uc002poo.3	+	4	1775	c.1775C>T	c.(1774-1776)TCA>TTA	p.S592L		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		TACCTGAGCTCAGTCTTGGCC	0.657													T	50099367	T	T	50099367	3	4	45	1	0	0	0	0	1	0	0	0	12584	838	29	3	1789	3	PRR12	19	50099367	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	4175713	50099367	9029616	83	2927											
LENG8	114823	broad.mit.edu	37	chr19	54968952	54968952	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	aaaaagtcgctgtgcatggtCaagtgccactggaaagagaa	12	7	1	1	rs142424676	by1000genomes	TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr19:54968952C>A	uc002qfv.1	+	11	1791	c.1647C>A	c.(1645-1647)GTC>GTA	p.V549V	LENG8_uc002qfw.2_Silent_p.V586V			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	549							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		TGTGCATGGTCAAGTGCCACT	0.537													A	54968952	A	A	54968952	2	1	45	1	0	0	0	0	0	0	0	1	8724	813	29	5		5	LENG8	19	54968952	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08	4869585	54968952	4160031	84	2928											
ZNF552	79818	broad.mit.edu	37	chr19	58319417	58319417	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcactgcactcataagccCtttcttttgtgaactctctg	5	13	4	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr19:58319417C>T	uc002qqg.2	-	3	1385	c.1215G>A	c.(1213-1215)AAG>AAA	p.K405K	ZNF587_uc002qqb.2_Intron|ZNF552_uc010yhg.1_Silent_p.K401K	NM_024762	NP_079038	Q9H707	ZN552_HUMAN	zinc finger protein 552	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		CTCATAAGCCCTTTCTTTTGT	0.398													T	58319417	T	T	58319417	2	4	45	1	0	0	0	0	0	0	0	1	17981	680	24	3		3	ZNF552	19	58319417	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08	3350465	58319417	809566	85	2929											
SIRPG	55423	broad.mit.edu	37	chr20	1615912	1615912	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaattttgagtaacctcaCcaggggtagcatctgagctc	9	9	2	2			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr20:1615912C>T	uc002wfm.1	-	4	1146	c.1081_splice	c.e4+1	p.G361_splice	SIRPG_uc002wfn.1_Intron|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1						blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						AGTAACCTCACCAGGGGTAGC	0.428													T	1615912	T	T	1615912	5	4	45	1	0	0	0	0	0	0	1	0	14336	521	18	3	89	3	SIRPG	20	1615912	Splice_Site	SNP	C	TCGA-06-0214-01A-02D-1491-08		1615912	61409608	86	2930											
TSHZ2	128553	broad.mit.edu	37	chr20	51872367	51872367	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtccccacctcagaagcaCgctctgtctgacatcgccga	8	16	3	2	rs138612067		TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr20:51872367C>T	uc002xwo.2	+	2	3326	c.2370C>T	c.(2368-2370)CAC>CAT	p.H790H		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	790					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CTCAGAAGCACGCTCTGTCTG	0.557													T	51872367	T	T	51872367	2	4	45	1	0	0	0	0	0	0	0	1	16621	535	19	1		1	TSHZ2	20	51872367	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08	50256455	51872367	11153153	87	2931											
ADRM1	11047	broad.mit.edu	37	chr20	60882680	60882680	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagtcggcagcggtcaccCcgtcatccaccacctcttcc	8	20	3	0			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr20:60882680C>T	uc002ycn.2	+	7	732	c.652C>T	c.(652-654)CCG>TCG	p.P218S	ADRM1_uc002yco.2_Missense_Mutation_p.P218S	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	218	Ser-rich.				proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			AGCGGTCACCCCGTCATCCAC	0.701													T	60882680	T	T	60882680	3	4	45	1	0	0	0	0	1	0	0	0	345	623	22	3	674	3	ADRM1	20	60882680	Missense_Mutation	SNP	C	TCGA-06-0214-01A-02D-1491-08	9010313	60882680	2142840	88	2932											
OSBP2	23762	broad.mit.edu	37	chr22	31137177	31137177	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaaatggcccacacgtgccGtggaaccatcaacctgtcca	9	14	1	1			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr22:31137177G>A	uc003aiy.1	+	2	778	c.674G>A	c.(673-675)CGT>CAT	p.R225H	OSBP2_uc011ala.1_Missense_Mutation_p.R60H|OSBP2_uc010gwc.1_Missense_Mutation_p.R52H|OSBP2_uc003aix.1_Missense_Mutation_p.R225H|OSBP2_uc011alb.1_Missense_Mutation_p.R225H|OSBP2_uc003aiz.1_Missense_Mutation_p.R225H	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	225	PH.				lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						CACACGTGCCGTGGAACCATC	0.542													A	31137177	A	A	31137177	3	1	45	1	0	0	0	0	1	0	0	0	11274	1145	40	1	680	1	OSBP2	22	31137177	Missense_Mutation	SNP	G	TCGA-06-0214-01A-02D-1491-08		31137177	20167389	89	2933											
EP300	2033	broad.mit.edu	37	chr22	41564810	41564810	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagaaattgatggtgttgacCtgtgcttctttggcatgcat	11	6	1	3			TCGA-06-0214-01A-02D-1491-08	TCGA-06-0214-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	08ac57ec-0036-4134-a9bb-f22eaa27ab0d	fc3f70c0-3e8f-4146-a308-8a71cb1031a0	g.chr22:41564810C>T	uc003azl.3	+	25	4506	c.4111C>T	c.(4111-4113)CTG>TTG	p.L1371L		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1371					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGGTGTTGACCTGTGCTTCTT	0.478			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				T	41564810	T	T	41564810	2	4	45	1	0	0	0	0	0	0	0	1	5148	680	24	3		3	EP300	22	41564810	Silent	SNP	C	TCGA-06-0214-01A-02D-1491-08	10427633	41564810	9739756	90	2934											
APITD1	378708	broad.mit.edu	37	chr1	10511616	10511616	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgggacagaatgccctgcagGaacttcttctggaagacctt	11	11	2	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:10511616G>T	uc001arf.2	+	5	875	c.459G>T	c.(457-459)AGG>AGT	p.R153S	APITD1_uc001arg.2_3'UTR|CORT_uc001ari.2_Missense_Mutation_p.R144S	NM_198544	NP_940946	Q8N2Z9	CENPS_HUMAN	apoptosis-inducing, TAF9-like domain 1 isoform	Error:Variant_position_missing_in_Q8N2Z9_after_alignment					DNA repair|mitotic prometaphase|transcription initiation, DNA-dependent	chromosome, centromeric region|cytosol|Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		TGCCCTGCAGGAACTTCTTCT	0.567													T	10511616	T	T	10511616	3	4	46	1	0	0	0	0	1	0	0	0	775	1165	41	5	622	5	APITD1	1	10511616	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08		10511616	238739005	1	2935											
RSPO1	284654	broad.mit.edu	37	chr1	38082340	38082340	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacaggcctggctcccctcGgcactgactgcaaaggtgga	13	14	0	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:38082340G>A	uc001cbl.1	-	5	890	c.102C>T	c.(100-102)GCC>GCT	p.A34A	RSPO1_uc001cbm.1_Silent_p.A34A|RSPO1_uc009vvf.1_Silent_p.A7A|RSPO1_uc009vvg.1_Silent_p.A34A	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	34	FU 1.				positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGCTCCCCTCGGCACTGACTG	0.557													A	38082340	A	A	38082340	2	1	46	1	0	0	0	0	0	0	0	1	13709	1103	39	2		2	RSPO1	1	38082340	Silent	SNP	G	TCGA-06-0216-01B-01D-1492-08	27570724	38082340	211168281	2	2936											
RPL5	6125	broad.mit.edu	37	chr1	93301897	93301898	+	Frame_Shift_Ins	INS	-	T	T													aactaccactggcaataaagINStttttggtgccctgaaggga							TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:93301897_93301898insT	uc001doz.2	+	5	553_554	c.475_476insT	c.(475-477)GTTfs	p.V159fs	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_RNA|RPL5_uc001dpb.2_Frame_Shift_Ins_p.V109fs|RPL5_uc001dpd.2_5'UTR|SNORD21_uc001dpe.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5	159					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		TGGCAATAAAGTTTTTGGTGCC	0.495													T	93301898	T	T	93301897	7	5	46	1	0	1	1	0	0	0	0	0	13597	1029	36	0	493	0	RPL5	1	93301897	Frame_Shift_Ins	INS	-	TCGA-06-0216-01B-01D-1492-08	55219557	93301897	155948724	3	2937											
HIPK1	204851	broad.mit.edu	37	chr1	114515777	114515777	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	catggcagcccgctacactcGacagggcacccacaccttgc	9	18	0	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:114515777G>T	uc001eem.2	+	16	3437	c.3276G>T	c.(3274-3276)TCG>TCT	p.S1092S	HIPK1_uc001een.2_Silent_p.S1092S|HIPK1_uc001eeo.2_Silent_p.S718S|HIPK1_uc001eep.2_Silent_p.S698S|HIPK1_uc001eeq.2_Silent_p.S384S	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	1092	Interaction with TP53.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGCTACACTCGACAGGGCACC	0.647													T	114515777	T	T	114515777	2	4	46	1	0	0	0	0	0	0	0	1	7116	1045	37	5		5	HIPK1	1	114515777	Silent	SNP	G	TCGA-06-0216-01B-01D-1492-08	21213880	114515777	134734844	4	2938											
CD2	914	broad.mit.edu	37	chr1	117311264	117311264	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcctggacaccgtgttcaGcaccagcctcagaagaggcc	10	16	2	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:117311264G>A	uc001egu.3	+	5	944	c.915G>A	c.(913-915)CAG>CAA	p.Q305Q		NM_001767	NP_001758	P06729	CD2_HUMAN	CD2 molecule precursor	305	Cytoplasmic (Potential).|Pro-rich.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			breast(1)	1	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	ACCGTGTTCAGCACCAGCCTC	0.622													A	117311264	A	A	117311264	2	1	46	1	0	0	0	0	0	0	0	1	2979	962	34	3		3	CD2	1	117311264	Silent	SNP	G	TCGA-06-0216-01B-01D-1492-08	2795487	117311264	131939357	5	2939											
TCHH	7062	broad.mit.edu	37	chr1	152084995	152084995	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggaacactctgtcttgcCgctctcgcctttgctgctgt	9	15	3	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:152084995C>T	uc001ezp.2	-	2	698	c.698G>A	c.(697-699)CGG>CAG	p.R233Q	TCHH_uc009wne.1_Missense_Mutation_p.R233Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	233					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGTCTTGCCGCTCTCGCCT	0.577													T	152084995	T	T	152084995	3	4	46	1	0	0	0	0	1	0	0	0	15697	652	23	2	5137	2	TCHH	1	152084995	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	34773731	152084995	97165626	6	2940											
PAPPA2	60676	broad.mit.edu	37	chr1	176526161	176526161	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	aacacagggtcaaaaagagtCcaccggaggaaagcaaccaa	10	10	1	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:176526161C>A	uc001gkz.2	+	2	1867	c.703C>A	c.(703-705)CCA>ACA	p.P235T	PAPPA2_uc001gky.1_Missense_Mutation_p.P235T|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	235					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CAAAAAGAGTCCACCGGAGGA	0.527													A	176526161	A	A	176526161	3	1	46	1	0	0	0	0	1	0	0	0	11433	855	30	5	705	5	PAPPA2	1	176526161	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	24441166	176526161	72724460	7	2941											
OR11L1	391189	broad.mit.edu	37	chr1	248004304	248004304	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	catgacctttctaacagcttCtttgaagtctttgttcctca	5	11	4	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr1:248004304C>A	uc001idn.1	-	1	895	c.895G>T	c.(895-897)GAA>TAA	p.E299*		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTAACAGCTTCTTTGAAGTCT	0.393													A	248004304	A	A	248004304	4	1	46	1	0	0	0	0	0	1	0	0	10930	922	32	5	77	5	OR11L1	1	248004304	Nonsense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	71478143	248004304	1246317	8	2942											
SMEK2	57223	broad.mit.edu	37	chr2	55791468	55791468	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttttttagtctccataaaCttttcataattatctggaaa	3	8	3	0	rs145292231		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr2:55791468C>T	uc002rzc.2	-	15	2616	c.2241G>A	c.(2239-2241)AAG>AAA	p.K747K	SMEK2_uc002rzb.2_Silent_p.K662K|SMEK2_uc002rzd.2_Silent_p.K715K|SMEK2_uc002ryz.2_Silent_p.K174K|SMEK2_uc002rza.2_Silent_p.K531K	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	747						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TCTCCATAAACTTTTCATAAT	0.333													T	55791468	T	T	55791468	2	4	46	1	0	0	0	0	0	0	0	1	14794	564	20	3		3	SMEK2	2	55791468	Silent	SNP	C	TCGA-06-0216-01B-01D-1492-08		55791468	187407905	9	2943											
TTN	7273	broad.mit.edu	37	chr2	179594120	179594120	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acacttggttatatggaggtTaaacacagacactctgtcgg	10	8	1	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr2:179594120T>A	uc010zfg.1	-	61	15255	c.15031A>T	c.(15031-15033)AAC>TAC	p.N5011Y	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.N1672Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5938							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATGGAGGTTAAACACAGAC	0.463													A	179594120	A	A	179594120	3	1	46	1	0	0	0	0	1	0	0	0	16732	1754	61	5	85962	5	TTN	2	179594120	Missense_Mutation	SNP	T	TCGA-06-0216-01B-01D-1492-08	123802652	179594120	63605253	10	2944											
INPP5D	3635	broad.mit.edu	37	chr2	233944058	233944058	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttcaggtatcggaattgcGtttacacttacagaattctg	8	7	2	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr2:233944058G>A	uc010zmo.1	+	2	301	c.148G>A	c.(148-150)GTT>ATT	p.V50I	INPP5D_uc010zmp.1_Missense_Mutation_p.V50I	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	50	SH2.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCGGAATTGCGTTTACACTTA	0.403													A	233944058	A	A	233944058	3	1	46	1	0	0	0	0	1	0	0	0	7756	1145	40	1	154	1	INPP5D	2	233944058	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	54349938	233944058	9255315	11	2945											
LRRC3B	116135	broad.mit.edu	37	chr3	26751911	26751911	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	caagcaggcagaagaaagcaGatgaacctgatgatattagc	11	7	0	6			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:26751911G>A	uc003cdp.2	+	2	1337	c.748G>A	c.(748-750)GAT>AAT	p.D250N	LRRC3B_uc003cdq.2_Missense_Mutation_p.D250N	NM_052953	NP_443185	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B precursor	250						integral to membrane				pancreas(2)|ovary(1)|skin(1)	4						GAAGAAAGCAGATGAACCTGA	0.418													A	26751911	A	A	26751911	3	1	46	1	0	0	0	0	1	0	0	0	8996	942	33	3	750	3	LRRC3B	3	26751911	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08		26751911	171270519	12	2946											
AZI2	64343	broad.mit.edu	37	chr3	28381958	28381958	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttctctgaatccttaagtcGttttttgatgtcttcatatg	6	7	3	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:28381958G>A	uc003ceb.2	-	2	683	c.151C>T	c.(151-153)CGA>TGA	p.R51*	AZI2_uc003cec.2_Translation_Start_Site|AZI2_uc003ced.2_Nonsense_Mutation_p.R51*|AZI2_uc003cee.3_Nonsense_Mutation_p.R51*|AZI2_uc003ceg.2_Nonsense_Mutation_p.R51*|AZI2_uc011axd.1_Nonsense_Mutation_p.R51*|AZI2_uc003cef.2_Nonsense_Mutation_p.R51*	NM_022461	NP_071906	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2 isoform a	51	Potential.					mitochondrion|plasma membrane				ovary(2)	2						TCCTTAAGTCGTTTTTTGATG	0.338													A	28381958	A	A	28381958	4	1	46	1	0	0	0	0	0	1	0	0	1241	1153	40	1	1144	1	AZI2	3	28381958	Nonsense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	1630047	28381958	169640472	13	2947											
IMPG2	50939	broad.mit.edu	37	chr3	100951684	100951684	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccatcattcaagcagaagtcAggctgtaggtcacagagact	10	10	4	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:100951684A>G	uc003duq.1	-	15	3377	c.3174T>C	c.(3172-3174)CCT>CCC	p.P1058P	IMPG2_uc011bhe.1_Silent_p.P921P|IMPG2_uc010hpj.1_RNA	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	1058	Extracellular (Potential).|EGF-like 2.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						AGCAGAAGTCAGGCTGTAGGT	0.488													G	100951684	G	G	100951684	2	3	46	1	0	0	0	0	0	0	0	1	7729	175	7	4		4	IMPG2	3	100951684	Silent	SNP	A	TCGA-06-0216-01B-01D-1492-08	72569726	100951684	97070746	14	2948											
DZIP3	9666	broad.mit.edu	37	chr3	108353719	108353719	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tacttttatttttttccaggGattttttcagttaatgtgca	6	5	1	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:108353719G>T	uc003dxd.2	+	10	1240	c.818G>T	c.(817-819)GGA>GTA	p.G273V	DZIP3_uc003dxf.1_Missense_Mutation_p.G273V|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Missense_Mutation_p.G273V|DZIP3_uc003dxg.1_5'UTR	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	273					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TTTTTCCAGGGATTTTTTCAG	0.254													T	108353719	T	T	108353719	3	4	46	1	0	0	0	0	1	0	0	0	4865	1188	41	5	852	5	DZIP3	3	108353719	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	7402035	108353719	89668711	15	2949											
CEP70	80321	broad.mit.edu	37	chr3	138289888	138289888	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttctcacctaagctgttgaTtagtttctataagctcctgt	6	9	2	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:138289888T>C	uc003esl.2	-	5	470	c.272A>G	c.(271-273)AAT>AGT	p.N91S	CEP70_uc011bmk.1_Missense_Mutation_p.N71S|CEP70_uc011bml.1_Missense_Mutation_p.N73S|CEP70_uc011bmm.1_Intron|CEP70_uc003esm.2_Missense_Mutation_p.N91S|CEP70_uc003esn.2_Missense_Mutation_p.N91S	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	91	Potential.				G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						AAGCTGTTGATTAGTTTCTAT	0.318													C	138289888	C	C	138289888	3	2	46	1	0	0	0	0	1	0	0	0	3259	1493	52	4	1577	4	CEP70	3	138289888	Missense_Mutation	SNP	T	TCGA-06-0216-01B-01D-1492-08	29936169	138289888	59732542	16	2950											
PHC3	80012	broad.mit.edu	37	chr3	169840418	169840418	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcaaatcttctcctctccCcactgttatagctgctggag	7	13	4	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:169840418C>T	uc010hws.1	-	9	1931	c.1867G>A	c.(1867-1869)GGG>AGG	p.G623R	PHC3_uc003fgl.2_Missense_Mutation_p.G635R|PHC3_uc011bpq.1_Missense_Mutation_p.G582R	NM_024947	NP_079223	Q8NDX5	PHC3_HUMAN	polyhomeotic like 3	623	Pro-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TCTCCTCTCCCCACTGTTATA	0.393													T	169840418	T	T	169840418	3	4	46	1	0	0	0	0	1	0	0	0	11818	623	22	3	1112	3	PHC3	3	169840418	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	31550530	169840418	28182012	17	2951											
FNDC3B	64778	broad.mit.edu	37	chr3	172096143	172096143	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgctactccttcagaatccAggcagcaagcgaggctggag	12	11	1	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr3:172096143A>G	uc003fhy.2	+	24	3264	c.3092A>G	c.(3091-3093)CAG>CGG	p.Q1031R	FNDC3B_uc003fhz.3_Missense_Mutation_p.Q1031R	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	1031	Fibronectin type-III 8.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TTCAGAATCCAGGCAGCAAGC	0.493													G	172096143	G	G	172096143	3	3	46	1	0	0	0	0	1	0	0	0	5970	188	7	4	3182	4	FNDC3B	3	172096143	Missense_Mutation	SNP	A	TCGA-06-0216-01B-01D-1492-08	2255725	172096143	25926287	18	2952											
SH3TC1	54436	broad.mit.edu	37	chr4	8229589	8229589	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacagccgcaagtgcctgcCccacctggtgctgagctgtg	12	15	0	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr4:8229589C>T	uc003gkv.3	+	12	2269	c.2168C>T	c.(2167-2169)CCC>CTC	p.P723L	SH3TC1_uc003gkw.3_Missense_Mutation_p.P647L|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	723							binding			large_intestine(2)|pancreas(1)	3						AAGTGCCTGCCCCACCTGGTG	0.657													T	8229589	T	T	8229589	3	4	46	1	0	0	0	0	1	0	0	0	14261	623	22	3	2210	3	SH3TC1	4	8229589	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08		8229589	182924687	19	2953											
KIAA1211	57482	broad.mit.edu	37	chr4	57181748	57181748	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagggaccagttgaggcccGgtgatgagtccactcccagg	15	11	0	4			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr4:57181748G>A	uc003hbk.2	+	8	2471	c.2080G>A	c.(2080-2082)GGT>AGT	p.G694S	KIAA1211_uc010iha.2_Missense_Mutation_p.G687S|KIAA1211_uc011bzz.1_Missense_Mutation_p.G604S|KIAA1211_uc003hbm.1_Missense_Mutation_p.G580S	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	694										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GTTGAGGCCCGGTGATGAGTC	0.602													A	57181748	A	A	57181748	3	1	46	1	0	0	0	0	1	0	0	0	8215	1116	39	2	2098	2	KIAA1211	4	57181748	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	48952159	57181748	133972528	20	2954											
OTUD4	54726	broad.mit.edu	37	chr4	146077118	146077118	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gacaaaggtttaaatccattCacatcagcagcagcagcagc	8	11	2	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr4:146077118C>T	uc003ika.3	-	8	603	c.465G>A	c.(463-465)GTG>GTA	p.V155V	OTUD4_uc003ijz.3_Silent_p.V155V	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	220							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					TAAATCCATTCACATCAGCAG	0.328													T	146077118	T	T	146077118	2	4	46	1	0	0	0	0	0	0	0	1	11314	813	29	3		3	OTUD4	4	146077118	Silent	SNP	C	TCGA-06-0216-01B-01D-1492-08	88895370	146077118	45077158	21	2955											
EFNA5	1946	broad.mit.edu	37	chr5	106762936	106762936	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagatgtagaaatattctcGgcctggcctgaattcaaatc	8	9	2	3	rs142282920		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr5:106762936G>A	uc003kol.2	-	2	682	c.400C>T	c.(400-402)CGA>TGA	p.R134*	EFNA5_uc010jbr.1_Nonsense_Mutation_p.R134*	NM_001962	NP_001953	P52803	EFNA5_HUMAN	ephrin-A5 precursor	134					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding				0		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		AAATATTCTCGGCCTGGCCTG	0.428													A	106762936	A	A	106762936	4	1	46	1	0	0	0	0	0	1	0	0	4954	1124	39	2	302	2	EFNA5	5	106762936	Nonsense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08		106762936	74152324	22	2956											
TBC1D9B	23061	broad.mit.edu	37	chr5	179315134	179315134	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtccacaacactggctttcCtgctcccgatactgcctggc	9	16	0	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr5:179315134C>T	uc003mlh.2	-	7	1260	c.1223G>A	c.(1222-1224)AGG>AAG	p.R408K	TBC1D9B_uc003mli.2_Missense_Mutation_p.R408K|TBC1D9B_uc003mlj.2_Missense_Mutation_p.R408K	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	408						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACTGGCTTTCCTGCTCCCGAT	0.567													T	179315134	T	T	179315134	3	4	46	1	0	0	0	0	1	0	0	0	15625	681	24	3	2593	3	TBC1D9B	5	179315134	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	72552198	179315134	1600126	23	2957											
KHDRBS2	202559	broad.mit.edu	37	chr6	62604633	62604633	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cgaggggtagggacacctctTgctacaggtggcactggaag	16	9	1	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr6:62604633T>A	uc003peg.2	-	6	964	c.717A>T	c.(715-717)GCA>GCT	p.A239A		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	239	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		GGACACCTCTTGCTACAGGTG	0.607													A	62604633	A	A	62604633	2	1	46	1	0	0	0	0	0	0	0	1	8147	1799	63	5		5	KHDRBS2	6	62604633	Silent	SNP	T	TCGA-06-0216-01B-01D-1492-08		62604633	108510434	24	2958											
GPR85	54329	broad.mit.edu	37	chr7	112724285	112724288	+	Frame_Shift_Del	DEL	TGAG	-	-													tgatcttcctccctaatgaaTgagtaagtgcccacgtctaa							TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr7:112724285_112724288delTGAG	uc010ljv.2	-	2	1006_1009	c.489_492delCTCA	c.(487-492)TACTCAfs	p.Y163fs	GPR85_uc003vgp.1_Frame_Shift_Del_p.Y163fs|GPR85_uc003vgq.2_Frame_Shift_Del_p.Y163fs|GPR85_uc010ljw.1_Frame_Shift_Del_p.Y163fs	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	163_164	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						CCCTAATGAATGAGTAAGTGCCCA	0.5													-	112724288	-	-	112724285	7	5	46	1	0	1	0	1	0	0	0	0	6715	1451	51	0	624	0	GPR85	7	112724285	Frame_Shift_Del	DEL	TGAG	TCGA-06-0216-01B-01D-1492-08		112724285	46414378	25	2959											
GIMAP6	474344	broad.mit.edu	37	chr7	150325381	150325381	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacctctggcgagacctggGgggacagaatgttgggtgtg	17	9	1	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr7:150325381G>A	uc003whn.2	-	3	729	c.305C>T	c.(304-306)CCC>CTC	p.P102L	GIMAP6_uc003whm.2_Intron	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	102							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGAGACCTGGGGGGACAGAAT	0.622													A	150325381	A	A	150325381	3	1	46	1	0	0	0	0	1	0	0	0	6383	1232	43	3	577	3	GIMAP6	7	150325381	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	37601096	150325381	8813282	26	2960											
ABP1	26	broad.mit.edu	37	chr7	150554420	150554420	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttctcctcccacaagcccCgcggggacttccccagcccc	7	22	2	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr7:150554420C>T	uc003why.1	+	3	5080	c.862C>T	c.(862-864)CGC>TGC	p.R288C	ABP1_uc003whz.1_Missense_Mutation_p.R288C|ABP1_uc003wia.1_Missense_Mutation_p.R288C	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	288					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	CCACAAGCCCCGCGGGGACTT	0.697													T	150554420	T	T	150554420	3	4	46	1	0	0	0	0	1	0	0	0	98	652	23	2	864	2	ABP1	7	150554420	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	229039	150554420	8584243	27	2961											
CPA6	57094	broad.mit.edu	37	chr8	68419124	68419124	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agtcgtgatcgtctgcccagCtgaaaacaagagcattcaca	9	11	2	3			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr8:68419124C>G	uc003xxq.3	-	6	791	c.535_splice	c.e6-1	p.L179_splice	CPA6_uc003xxr.3_Splice_Site_p.L31_splice|CPA6_uc003xxs.2_Splice_Site_p.L179_splice	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor						proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			GTCTGCCCAGCTGAAAACAAG	0.408													G	68419124	G	G	68419124	5	3	46	1	0	0	0	0	0	0	1	0	3794	811	28	5	803	5	CPA6	8	68419124	Splice_Site	SNP	C	TCGA-06-0216-01B-01D-1492-08		68419124	77944898	28	2962											
CDH17	1015	broad.mit.edu	37	chr8	95189845	95189845	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagtagatcttgtttccctGtccaaggctctgttgtaata	9	8	2	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr8:95189845G>A	uc003ygh.2	-	4	380	c.255C>T	c.(253-255)GAC>GAT	p.D85D	CDH17_uc011lgo.1_Silent_p.D85D|CDH17_uc011lgp.1_Silent_p.D85D	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	85	Extracellular (Potential).|Cadherin 1.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TTGTTTCCCTGTCCAAGGCTC	0.458													A	95189845	A	A	95189845	2	1	46	1	0	0	0	0	0	0	0	1	3102	1368	48	3		3	CDH17	8	95189845	Silent	SNP	G	TCGA-06-0216-01B-01D-1492-08	26770721	95189845	51174177	29	2963											
NFIB	4781	broad.mit.edu	37	chr9	14307244	14307244	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggattggataagacacagcaCgggtgcttcttgccagtcac	12	10	2	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:14307244C>T	uc003zle.2	-	2	741	c.306G>A	c.(304-306)CCG>CCA	p.P102P	NFIB_uc003zlf.2_Silent_p.P102P|NFIB_uc011lmo.1_Silent_p.P102P	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	102	CTF/NF-I.				anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		AGACACAGCACGGGTGCTTCT	0.527			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								T	14307244	T	T	14307244	2	4	46	1	0	0	0	0	0	0	0	1	10371	523	19	1		1	NFIB	9	14307244	Silent	SNP	C	TCGA-06-0216-01B-01D-1492-08		14307244	126906187	30	2964											
SHB	6461	broad.mit.edu	37	chr9	37948668	37948668	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcatgcttgctggtctggCtgttccggacaaggtagcta	13	9	2	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:37948668C>T	uc004aax.2	-	5	1878	c.1310G>A	c.(1309-1311)AGC>AAC	p.S437N		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	437	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GCTGGTCTGGCTGTTCCGGAC	0.647													T	37948668	T	T	37948668	3	4	46	1	0	0	0	0	1	0	0	0	14268	797	28	3	227	3	SHB	9	37948668	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	23641424	37948668	103264763	31	2965											
ALDOB	229	broad.mit.edu	37	chr9	104187273	104187273	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggcaaaggttgatagcattgAggttgagagtggcatcctct	14	6	1	3			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:104187273A>T	uc004bbk.2	-	8	933	c.851T>A	c.(850-852)CTC>CAC	p.L284H		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	284			L -> P (in HFI).		fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GATAGCATTGAGGTTGAGAGT	0.517													T	104187273	T	T	104187273	3	4	46	1	0	0	0	0	1	0	0	0	508	304	11	5	251	5	ALDOB	9	104187273	Missense_Mutation	SNP	A	TCGA-06-0216-01B-01D-1492-08	66238605	104187273	37026158	32	2966											
PTGS1	5742	broad.mit.edu	37	chr9	125146014	125146014	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgatgagcagcttttccagaCgacccgcctcatcctcatag	8	15	2	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:125146014C>T	uc004bmg.1	+	8	1124	c.989C>T	c.(988-990)ACG>ATG	p.T330M	PTGS1_uc011lys.1_Missense_Mutation_p.T305M|PTGS1_uc010mwb.1_Missense_Mutation_p.T221M|PTGS1_uc004bmf.1_Missense_Mutation_p.T330M|PTGS1_uc004bmh.1_Missense_Mutation_p.T221M|PTGS1_uc011lyt.1_Missense_Mutation_p.T221M	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	330					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	CTTTTCCAGACGACCCGCCTC	0.607													T	125146014	T	T	125146014	3	4	46	1	0	0	0	0	1	0	0	0	12755	536	19	1	1019	1	PTGS1	9	125146014	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	20958741	125146014	16067417	33	2967											
COQ4	51117	broad.mit.edu	37	chr9	131088069	131088069	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctttcagggagcgtccccGgatttcgacatccaccctcg	10	16	1	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr9:131088069G>A	uc004bur.3	+	4	658	c.311G>A	c.(310-312)CGG>CAG	p.R104Q	COQ4_uc011max.1_Missense_Mutation_p.R104Q|COQ4_uc004bus.2_Missense_Mutation_p.R80Q|COQ4_uc010mxy.2_Missense_Mutation_p.R80Q	NM_016035	NP_057119	Q9Y3A0	COQ4_HUMAN	coenzyme Q4 homolog precursor	104					ubiquinone biosynthetic process	mitochondrial inner membrane					0						GAGCGTCCCCGGATTTCGACA	0.587													A	131088069	A	A	131088069	3	1	46	1	0	0	0	0	1	0	0	0	3747	1116	39	2	325	2	COQ4	9	131088069	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	5942055	131088069	10125362	34	2968											
AGAP6	414189	broad.mit.edu	37	chr10	51768724	51768724	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgacaccatcgggagcggtaGagccatccccattaaacagg	11	12	0	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr10:51768724G>C	uc001jix.3	+	8	1237	c.839G>C	c.(838-840)AGA>ACA	p.R280T		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	280					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						GGGAGCGGTAGAGCCATCCCC	0.507													C	51768724	C	C	51768724	3	2	46	1	0	0	0	0	1	0	0	0	372	942	33	5	869	5	AGAP6	10	51768724	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08		51768724	83766023	35	2969											
PTEN	5728	broad.mit.edu	37	chr10	89692835	89692835	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttatcaaacccttttgtgaaGatcttgaccaatggctaagt	7	8	2	3	rs57374291		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr10:89692835G>C	uc001kfb.2	+	6	1350	c.319G>C	c.(319-321)GAT>CAT	p.D107H		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	107	Phosphatase tensin-type.		D -> Y (in BZS and glioblastoma; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.D107Y(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.D107N(1)|p.D107A(1)|p.F56fs*2(1)|p.P103fs*3(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTTTTGTGAAGATCTTGACCA	0.368		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89692835	C	C	89692835	3	2	46	1	0	0	0	0	1	0	0	0	12738	942	33	5	337	5	PTEN	10	89692835	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	37924111	89692835	45841912	36	2970											
BNIP3	664	broad.mit.edu	37	chr10	133787377	133787377	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	attttttccatgtctccattAtaaatagaaaccgaggctgg	7	8	1	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr10:133787377A>T	uc001lkv.1	-	2	243	c.117T>A	c.(115-117)TAT>TAA	p.Y39*	BNIP3_uc010qut.1_Nonsense_Mutation_p.Y39*	NM_004052	NP_004043	Q12983	BNIP3_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein 3	39					cellular response to cobalt ion|cellular response to hypoxia|cellular response to mechanical stimulus|chromatin remodeling|defense response to virus|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis|interspecies interaction between organisms|mitochondrial fragmentation involved in apoptosis|negative regulation of membrane potential|negative regulation of mitochondrial fusion|negative regulation of survival gene product expression|neuron apoptosis|positive regulation of mitochondrial fission|positive regulation of protein complex disassembly|positive regulation of release of cytochrome c from mitochondria|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability	dendrite|integral to mitochondrial outer membrane|nuclear envelope|nucleoplasm	GTPase binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|skin(1)	2		all_cancers(35;4e-11)|all_epithelial(44;5.07e-08)|Ovarian(717;2.61e-05)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Breast(234;0.023)|all_neural(114;0.0299)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)		Epithelial(32;1.59e-12)|all cancers(32;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(35;2.57e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TGTCTCCATTATAAATAGAAA	0.517													T	133787377	T	T	133787377	4	4	46	1	0	0	0	0	0	1	0	0	1478	456	16	5	487	5	BNIP3	10	133787377	Nonsense_Mutation	SNP	A	TCGA-06-0216-01B-01D-1492-08	44094542	133787377	1747370	37	2971											
MRGPRX4	117196	broad.mit.edu	37	chr11	18195500	18195500	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctctgcggcctgcccttcGgcattctgggggccctaatt	11	15	2	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:18195500G>A	uc001mnv.1	+	1	1117	c.697G>A	c.(697-699)GGC>AGC	p.G233S		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	233	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CCTGCCCTTCGGCATTCTGGG	0.527													A	18195500	A	A	18195500	3	1	46	1	0	0	0	0	1	0	0	0	9769	1116	39	2	699	2	MRGPRX4	11	18195500	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08		18195500	116811016	38	2972											
LRRC4C	57689	broad.mit.edu	37	chr11	40137192	40137192	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctcatctagttttatgagCggtgtgaggttagggatttc	13	5	2	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:40137192C>T	uc001mxa.1	-	2	2615	c.651G>A	c.(649-651)CCG>CCA	p.P217P	LRRC4C_uc001mxc.1_Silent_p.P213P|LRRC4C_uc001mxd.1_Silent_p.P213P|LRRC4C_uc001mxb.1_Silent_p.P213P	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	217	LRR 6.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTTTTATGAGCGGTGTGAGGT	0.458													T	40137192	T	T	40137192	2	4	46	1	0	0	0	0	0	0	0	1	9008	755	27	1		1	LRRC4C	11	40137192	Silent	SNP	C	TCGA-06-0216-01B-01D-1492-08	21941692	40137192	94869324	39	2973											
LRRC55	219527	broad.mit.edu	37	chr11	56950084	56950084	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	accctgcagatcggtggcaaTccctgggtgtgtggctgcac	14	12	0	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:56950084T>A	uc001njl.1	+	1	864	c.717T>A	c.(715-717)AAT>AAA	p.N239K		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	209	LRRCT.					integral to membrane					0						TCGGTGGCAATCCCTGGGTGT	0.632													A	56950084	A	A	56950084	3	1	46	1	0	0	0	0	1	0	0	0	9011	1432	50	5	719	5	LRRC55	11	56950084	Missense_Mutation	SNP	T	TCGA-06-0216-01B-01D-1492-08	16812892	56950084	78056432	40	2974											
DAGLA	747	broad.mit.edu	37	chr11	61511858	61511858	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgacgcccacgggcctcaGtagccaggaatgcctggcgg	14	15	1	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:61511858G>A	uc001nsa.2	+	20	3137	c.3026G>A	c.(3025-3027)AGT>AAT	p.S1009N		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	1009	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		ACGGGCCTCAGTAGCCAGGAA	0.657													A	61511858	A	A	61511858	3	1	46	1	0	0	0	0	1	0	0	0	4226	1029	36	3	3100	3	DAGLA	11	61511858	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	4561774	61511858	73494658	41	2975											
STX5	6811	broad.mit.edu	37	chr11	62593006	62593006	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	atttgtttgttgaggctattGatgtcctggtaaaagagtcc	11	5	0	3			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:62593006G>C	uc001nvh.2	-	6	583	c.429C>G	c.(427-429)ATC>ATG	p.I143M	STX5_uc010rmi.1_Missense_Mutation_p.I47M|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Missense_Mutation_p.I89M|STX5_uc010rmj.1_Missense_Mutation_p.I143M|STX5_uc001nvj.2_Translation_Start_Site	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	143	Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						TGAGGCTATTGATGTCCTGGT	0.507													C	62593006	C	C	62593006	3	2	46	1	0	0	0	0	1	0	0	0	15347	1280	45	5	662	5	STX5	11	62593006	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	1081148	62593006	72413510	42	2976											
NUMA1	4926	broad.mit.edu	37	chr11	71717271	71717271	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagaccgcgtgctgtagaaCgatgagttggcgctgtctgg	16	9	1	3			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:71717271C>T	uc001orl.1	-	22	5674	c.5502G>A	c.(5500-5502)TCG>TCA	p.S1834S	NUMA1_uc001orj.2_Silent_p.S16S|NUMA1_uc009ysw.1_Silent_p.S1401S|NUMA1_uc001ork.1_Silent_p.S698S|NUMA1_uc001orm.1_Silent_p.S1820S	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1834					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						TGCTGTAGAACGATGAGTTGG	0.552			T	RARA	APL								T	71717271	T	T	71717271	2	4	46	1	0	0	0	0	0	0	0	1	10750	523	19	1		1	NUMA1	11	71717271	Silent	SNP	C	TCGA-06-0216-01B-01D-1492-08	9124265	71717271	63289245	43	2977											
FOLR4	390243	broad.mit.edu	37	chr11	94040846	94040846	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctgctccctgttcctgccGttcctttcctgagagccctt	8	16	1	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr11:94040846G>A	uc010rud.1	+	4	720	c.720G>A	c.(718-720)CCG>CCA	p.P240P		NM_001080486	NP_001073955	A6ND01	FOLR4_HUMAN	folate receptor 4 (delta) homolog	247						extracellular region	folic acid binding|receptor activity			ovary(1)	1						TGTTCCTGCCGTTCCTTTCCT	0.617													A	94040846	A	A	94040846	2	1	46	1	0	0	0	0	0	0	0	1	5984	1132	40	1		1	FOLR4	11	94040846	Silent	SNP	G	TCGA-06-0216-01B-01D-1492-08	22323575	94040846	40965670	44	2978											
BCAT1	586	broad.mit.edu	37	chr12	25047326	25047326	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccaccgtcagcatatgatcCgtgaacacagttccaaaaac	6	13	1	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr12:25047326C>T	uc001rgd.3	-	3	604	c.162G>A	c.(160-162)ACG>ACA	p.T54T	BCAT1_uc001rgc.2_Silent_p.T53T|BCAT1_uc010six.1_Silent_p.T66T|BCAT1_uc010siy.1_Silent_p.T54T|BCAT1_uc001rge.3_Silent_p.T30T	NM_005504	NP_005495	P54687	BCAT1_HUMAN	branched chain aminotransferase 1, cytosolic	54					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			lung(1)|breast(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	GCATATGATCCGTGAACACAG	0.453													T	25047326	T	T	25047326	2	4	46	1	0	0	0	0	0	0	0	1	1354	639	23	2		2	BCAT1	12	25047326	Silent	SNP	C	TCGA-06-0216-01B-01D-1492-08		25047326	108804569	45	2979											
CIT	11113	broad.mit.edu	37	chr12	120142198	120142198	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtatttgctgaggttttcGttgtagcggagaatgacgac	13	6	0	3			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr12:120142198G>A	uc001txi.1	-	40	5201	c.5148C>T	c.(5146-5148)AAC>AAT	p.N1716N	CIT_uc001txh.1_Silent_p.N1235N|CIT_uc001txj.1_Silent_p.N1758N	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1716	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGAGGTTTTCGTTGTAGCGGA	0.512													A	120142198	A	A	120142198	2	1	46	1	0	0	0	0	0	0	0	1	3438	1136	40	1		1	CIT	12	120142198	Silent	SNP	G	TCGA-06-0216-01B-01D-1492-08	95094872	120142198	13709697	46	2980											
AACS	65985	broad.mit.edu	37	chr12	125621257	125621257	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgtgtcccccagtataaCaagtacagggaggagagggt	14	8	0	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr12:125621257C>T	uc001uhc.2	+	17	1934	c.1728C>T	c.(1726-1728)AAC>AAT	p.N576N	AACS_uc001uhd.2_Intron|AACS_uc009zyh.2_RNA|AACS_uc009zyi.2_Silent_p.N174N	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	576					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		CCCAGTATAACAAGTACAGGG	0.597													T	125621257	T	T	125621257	2	4	46	1	0	0	0	0	0	0	0	1	9	477	17	3		3	AACS	12	125621257	Silent	SNP	C	TCGA-06-0216-01B-01D-1492-08	5479059	125621257	8230638	47	2981											
GALNT9	50614	broad.mit.edu	37	chr12	132688129	132688129	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcggcgcgcagggcgttgCgcttggcatagtagtcaatg	17	10	1	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr12:132688129C>T	uc001ukc.3	-	7	1300	c.1184G>A	c.(1183-1185)CGC>CAC	p.R395H	GALNT9_uc009zyr.2_Missense_Mutation_p.R169H|GALNT9_uc001ukb.2_Missense_Mutation_p.R252H|GALNT9_uc001uka.2_Missense_Mutation_p.R29H	NM_001122636	NP_001116108	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	395	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		CAGGGCGTTGCGCTTGGCATA	0.637													T	132688129	T	T	132688129	3	4	46	1	0	0	0	0	1	0	0	0	6220	768	27	1	647	1	GALNT9	12	132688129	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	7066872	132688129	1163766	48	2982											
HTR2A	3356	broad.mit.edu	37	chr13	47466570	47466570	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gattttcagaaatgccttagTtctggagttgaagcggctgt	12	6	2	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr13:47466570T>C	uc001vbq.2	-	2	702	c.568A>G	c.(568-570)ACT>GCT	p.T190A	HTR2A_uc001vbr.2_Missense_Mutation_p.T90A|HTR2A_uc010acr.2_Missense_Mutation_p.T190A	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	190	Cytoplasmic (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AATGCCTTAGTTCTGGAGTTG	0.493													C	47466570	C	C	47466570	3	2	46	1	0	0	0	0	1	0	0	0	7441	1725	60	4	855	4	HTR2A	13	47466570	Missense_Mutation	SNP	T	TCGA-06-0216-01B-01D-1492-08		47466570	67703308	49	2983											
DIS3	22894	broad.mit.edu	37	chr13	73355005	73355005	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatggtgctcattagtgaaaGtatagaaatgcttctcttgg	10	5	2	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr13:73355005G>A	uc001vix.3	-	2	739	c.365C>T	c.(364-366)ACT>ATT	p.T122I	PIBF1_uc001vja.1_5'Flank|PIBF1_uc010aeo.1_5'Flank|PIBF1_uc001vjb.2_5'Flank|PIBF1_uc001vjc.2_5'Flank|PIBF1_uc010aep.2_5'Flank|DIS3_uc001viy.3_Intron|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	122	PINc.				CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		ATTAGTGAAAGTATAGAAATG	0.388										Multiple Myeloma(4;0.011)			A	73355005	A	A	73355005	3	1	46	1	0	0	0	0	1	0	0	0	4535	1029	36	3	2591	3	DIS3	13	73355005	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	25888435	73355005	41814873	50	2984											
KIAA0430	9665	broad.mit.edu	37	chr16	15692768	15692768	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcagcagattggaggataaCggggtctggtctcagctgag	15	7	3	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr16:15692768C>T	uc002ddr.2	-	26	5120	c.4927G>A	c.(4927-4929)GTT>ATT	p.V1643I	KIAA0430_uc002ddq.2_Missense_Mutation_p.V1477I|KIAA0430_uc010uzv.1_Missense_Mutation_p.V1639I|KIAA0430_uc010uzw.1_Missense_Mutation_p.V1642I	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1642						peroxisome	nucleotide binding|RNA binding				0						TGGAGGATAACGGGGTCTGGT	0.592													T	15692768	T	T	15692768	3	4	46	1	0	0	0	0	1	0	0	0	8177	536	19	1	309	1	KIAA0430	16	15692768	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08		15692768	74661985	51	2985											
VPS35	55737	broad.mit.edu	37	chr16	46694426	46694426	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attggcccctcggattctggTgattcccgccgcaagcgcaa	11	14	1	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr16:46694426T>G	uc002eef.3	-	17	2448	c.2349A>C	c.(2347-2349)TCA>TCC	p.S783S	VPS35_uc002eed.2_3'UTR|VPS35_uc002eee.2_Silent_p.S744S	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	783					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CGGATTCTGGTGATTCCCGCC	0.438													G	46694426	G	G	46694426	2	3	46	1	0	0	0	0	0	0	0	1	17200	1683	59	5		5	VPS35	16	46694426	Silent	SNP	T	TCGA-06-0216-01B-01D-1492-08	31001658	46694426	43660327	52	2986											
ABCC11	85320	broad.mit.edu	37	chr16	48247385	48247385	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcactgcagacttggaattcGtgagacctttgactgcaata	9	9	1	3	rs148839428		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr16:48247385G>A	uc002eff.1	-	9	1675	c.1325C>T	c.(1324-1326)ACG>ATG	p.T442M	ABCC11_uc002efg.1_Missense_Mutation_p.T442M|ABCC11_uc002efh.1_Missense_Mutation_p.T442M|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	442	Cytoplasmic (Potential).|ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CTTGGAATTCGTGAGACCTTT	0.552									Cerumen_Type				A	48247385	A	A	48247385	3	1	46	1	0	0	0	0	1	0	0	0	51	1145	40	1	2907	1	ABCC11	16	48247385	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	1552959	48247385	42107368	53	2987											
CNGB1	1258	broad.mit.edu	37	chr16	57993926	57993926	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcagggagggggtctcccgGgcctgcagcttgggccccat	18	13	1	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr16:57993926G>A	uc002emt.2	-	10	692	c.627C>T	c.(625-627)GCC>GCT	p.A209A	CNGB1_uc010cdh.2_Silent_p.A203A|CNGB1_uc002emu.2_Silent_p.A209A	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	209	Pro-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GGGTCTCCCGGGCCTGCAGCT	0.687													A	57993926	A	A	57993926	2	1	46	1	0	0	0	0	0	0	0	1	3600	1219	43	3		3	CNGB1	16	57993926	Silent	SNP	G	TCGA-06-0216-01B-01D-1492-08	9746541	57993926	32360827	54	2988											
SMTNL2	342527	broad.mit.edu	37	chr17	4496362	4496362	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtctctgacaggttctctgGggagacctcagctgcggctc	13	12	3	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr17:4496362G>A	uc002fyf.1	+	3	693	c.626G>A	c.(625-627)GGG>GAG	p.G209E	SMTNL2_uc002fye.2_Missense_Mutation_p.G65E	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	209											0				READ - Rectum adenocarcinoma(115;0.0325)		AGGTTCTCTGGGGAGACCTCA	0.657													A	4496362	A	A	4496362	3	1	46	1	0	0	0	0	1	0	0	0	14816	1232	43	3	636	3	SMTNL2	17	4496362	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08		4496362	76698848	55	2989											
TMEM220	388335	broad.mit.edu	37	chr17	10628403	10628403	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaagccaacagcccacaccGtacaaaagagtatgtgtatt	7	12	0	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr17:10628403G>A	uc002gmx.2	-	4	690	c.212C>T	c.(211-213)ACG>ATG	p.T71M	TMEM220_uc002gmy.2_Missense_Mutation_p.T61M	NM_001004313	NP_001004313	Q6QAJ8	TM220_HUMAN	transmembrane protein 220	71	Helical; (Potential).					integral to membrane					0						AGCCCACACCGTACAAAAGAG	0.448													A	10628403	A	A	10628403	3	1	46	1	0	0	0	0	1	0	0	0	16141	1145	40	1	282	1	TMEM220	17	10628403	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	6132041	10628403	70566807	56	2990											
HAP1	9001	broad.mit.edu	37	chr17	39884047	39884047	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcatctggatttccttctcCgaagccagctgcttctgcaa	8	13	3	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr17:39884047C>T	uc002hxm.1	-	8	1254	c.1242G>A	c.(1240-1242)TCG>TCA	p.S414S	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Silent_p.S414S|HAP1_uc002hxo.1_Intron|HAP1_uc002hxp.1_Intron	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	414	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TTTCCTTCTCCGAAGCCAGCT	0.622													T	39884047	T	T	39884047	2	4	46	1	0	0	0	0	0	0	0	1	6953	639	23	2		2	HAP1	17	39884047	Silent	SNP	C	TCGA-06-0216-01B-01D-1492-08	29255644	39884047	41311163	57	2991											
MUC16	94025	broad.mit.edu	37	chr19	9071728	9071728	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtcaggtggcactgtggactTatcatggtctggggtggaaa	16	6	3	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr19:9071728T>C	uc002mkp.2	-	3	15922	c.15718A>G	c.(15718-15720)AAG>GAG	p.K5240E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5242	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTGTGGACTTATCATGGTCT	0.478													C	9071728	C	C	9071728	3	2	46	1	0	0	0	0	1	0	0	0	9973	1763	61	4	28133	4	MUC16	19	9071728	Missense_Mutation	SNP	T	TCGA-06-0216-01B-01D-1492-08		9071728	50057255	58	2992											
CD22	933	broad.mit.edu	37	chr19	35832284	35832285	+	Frame_Shift_Ins	INS	-	T	T													ggtccggaaaatcaagccccINStttccgagattcactctgga							TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr19:35832284_35832285insT	uc010edt.2	+	8	1623_1624	c.1546_1547insT	c.(1546-1548)CTTfs	p.L516fs	CD22_uc010xst.1_Frame_Shift_Ins_p.L344fs|CD22_uc010edu.2_Frame_Shift_Ins_p.L428fs|CD22_uc010edv.2_Frame_Shift_Ins_p.L516fs|CD22_uc002nzb.3_Frame_Shift_Ins_p.L339fs|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	516	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AATCAAGCCCCTTTCCGAGATT	0.574													T	35832285	T	T	35832284	7	5	46	1	0	1	1	0	0	0	0	0	2985	681	24	0	1572	0	CD22	19	35832284	Frame_Shift_Ins	INS	-	TCGA-06-0216-01B-01D-1492-08	26760556	35832284	23296699	59	2993											
GLTSCR2	29997	broad.mit.edu	37	chr19	48259848	48259848	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggaggaatatgatcgagcctCgagagagagccaagtaaggg	16	6	0	3	rs141718194		TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr19:48259848C>T	uc002phm.2	+	11	1384	c.1360C>T	c.(1360-1362)CGA>TGA	p.R454*	GLTSCR2_uc002phk.2_3'UTR|GLTSCR2_uc002phl.2_Nonsense_Mutation_p.R454*|GLTSCR2_uc010elj.2_Intron|GLTSCR2_uc010elk.1_RNA	NM_015710	NP_056525	Q9NZM5	GSCR2_HUMAN	glioma tumor suppressor candidate region gene 2	454				EGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAFR EIQL -> RGQHSFETGSRAFRGGI (in Ref. 3; AAG30413).|PEGNILRDRFKSFQRRNMIEPRERAKFKRKYKVKLVEKRAF REIQ -> VLTVSCRGAPCPVMTPSLLPVPPRGYGRHHGCP WAGPVGPMPRG (in Ref. 5).		nucleolus				central_nervous_system(1)	1		all_cancers(25;1.47e-06)|all_lung(116;6.89e-05)|all_epithelial(76;0.000108)|Lung NSC(112;0.000117)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000301)|OV - Ovarian serous cystadenocarcinoma(262;0.00031)|Epithelial(262;0.0149)|GBM - Glioblastoma multiforme(486;0.0278)		GATCGAGCCTCGAGAGAGAGC	0.632													T	48259848	T	T	48259848	4	4	46	1	0	0	0	0	0	1	0	0	6475	876	31	2	1402	2	GLTSCR2	19	48259848	Nonsense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	12427564	48259848	10869135	60	2994											
NLRP12	91662	broad.mit.edu	37	chr19	54304629	54304629	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctcgtcacaggcagcagCagtgaggcggcagatcttca	13	12	3	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr19:54304629C>T	uc002qch.3	-	7	2828	c.2608G>A	c.(2608-2610)GCT>ACT	p.A870T	NLRP12_uc010eqw.2_Missense_Mutation_p.A153T|NLRP12_uc002qci.3_Missense_Mutation_p.A870T|NLRP12_uc002qcj.3_Missense_Mutation_p.A871T|NLRP12_uc002qck.3_Intron|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	870	LRR 2.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CAGGCAGCAGCAGTGAGGCGG	0.468													T	54304629	T	T	54304629	3	4	46	1	0	0	0	0	1	0	0	0	10474	710	25	3	593	3	NLRP12	19	54304629	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	6044781	54304629	4824354	61	2995											
WFDC13	164237	broad.mit.edu	37	chr20	44334525	44334525	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caaacacaagggctcagaagTcatcatgcctgccaactgag	9	12	3	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chr20:44334525T>C	uc002xpd.2	+	3	371	c.263T>C	c.(262-264)GTC>GCC	p.V88A	WFDC10B_uc002xpb.2_5'Flank|WFDC10B_uc002xpc.2_5'Flank	NM_172005	NP_742002	Q8IUB5	WFD13_HUMAN	WAP four-disulfide core domain 13 precursor	88						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GGCTCAGAAGTCATCATGCCT	0.353													C	44334525	C	C	44334525	3	2	46	1	0	0	0	0	1	0	0	0	17348	1667	58	4	273	4	WFDC13	20	44334525	Missense_Mutation	SNP	T	TCGA-06-0216-01B-01D-1492-08		44334525	18690995	62	2996											
KLHL15	80311	broad.mit.edu	37	chrX	24006559	24006559	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaagatgaggtgattccacCggtgataaacaatttgttat	11	5	0	4			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:24006559C>T	uc004dba.3	-	4	1550	c.1294G>A	c.(1294-1296)GGT>AGT	p.G432S		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	432	Kelch 3.									ovary(1)|breast(1)	2						GTGATTCCACCGGTGATAAAC	0.443													T	24006559	T	T	24006559	3	4	46	1	0	0	0	0	1	0	0	0	8371	652	23	2	524	2	KLHL15	23	24006559	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08		24006559	131264001	63	2997											
FGD1	2245	broad.mit.edu	37	chrX	54496521	54496521	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcctcctcctcctcgtcGtcctcctcctccaggtcact	4	21	2	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:54496521G>A	uc004dtg.2	-	4	1763	c.1029C>T	c.(1027-1029)GAC>GAT	p.D343D	FGD1_uc011moi.1_Silent_p.D101D	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	343					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						cctcctcgtcgtcctcctcct	0.507													A	54496521	A	A	54496521	2	1	46	1	0	0	0	0	0	0	0	1	5832	1136	40	1		1	FGD1	23	54496521	Silent	SNP	G	TCGA-06-0216-01B-01D-1492-08	30489962	54496521	100774039	64	2998											
ZMYM3	9203	broad.mit.edu	37	chrX	70467290	70467290	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgctggttgcagaaatgaCggatctgcccacgccagtgg	13	11	1	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:70467290C>T	uc004dzh.1	-	13	2306	c.2219G>A	c.(2218-2220)CGT>CAT	p.R740H	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.R740H|ZMYM3_uc004dzj.1_Missense_Mutation_p.R740H	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	740					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					GCAGAAATGACGGATCTGCCC	0.582													T	70467290	T	T	70467290	3	4	46	1	0	0	0	0	1	0	0	0	17698	536	19	1	1945	1	ZMYM3	23	70467290	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	15970769	70467290	84803270	65	2999											
CAPN6	827	broad.mit.edu	37	chrX	110494147	110494147	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaagtaattgactcaaacctGgggattctgcaggaaggtat	11	6	2	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:110494147G>T	uc004epc.1	-	8	1324	c.1156C>A	c.(1156-1158)CAG>AAG	p.Q386K	CAPN6_uc011msu.1_Missense_Mutation_p.Q131K	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	386	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						ACTCAAACCTGGGGATTCTGC	0.453													T	110494147	T	T	110494147	3	4	46	1	0	0	0	0	1	0	0	0	2630	1357	47	5	793	5	CAPN6	23	110494147	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	40026857	110494147	44776413	66	3000											
DDX26B	203522	broad.mit.edu	37	chrX	134714081	134714081	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgaaggaagttcgaaagtttGgtcgaagtaagtagtgaaag	14	2	0	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:134714081G>C	uc004eyw.3	+	15	2740	c.2377G>C	c.(2377-2379)GGT>CGT	p.G793R	DDX26B_uc004eyx.3_Missense_Mutation_p.G394R	NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	793											0	Acute lymphoblastic leukemia(192;6.56e-05)					TCGAAAGTTTGGTCGAAGTAA	0.373													C	134714081	C	C	134714081	3	2	46	1	0	0	0	0	1	0	0	0	4353	1348	47	5	2435	5	DDX26B	23	134714081	Missense_Mutation	SNP	G	TCGA-06-0216-01B-01D-1492-08	24219934	134714081	20556479	67	3001											
GPR101	83550	broad.mit.edu	37	chrX	136113330	136113330	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggcagcctggccccagccGtagagtggaggagtgctctg	16	11	1	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:136113330G>A	uc011mwh.1	-	1	504	c.504C>T	c.(502-504)TAC>TAT	p.Y168Y		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	168	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GGCCCCAGCCGTAGAGTGGAG	0.607													A	136113330	A	A	136113330	2	1	46	1	0	0	0	0	0	0	0	1	6622	1140	40	1		1	GPR101	23	136113330	Silent	SNP	G	TCGA-06-0216-01B-01D-1492-08	1399249	136113330	19157230	68	3002											
SOX3	6658	broad.mit.edu	37	chrX	139587063	139587063	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcgctcccggggctggagCggccacggtgaaaaggccct	17	13	0	1			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:139587063C>T	uc004fbd.1	-	1	163	c.163G>A	c.(163-165)GCT>ACT	p.A55T		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	55					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					GGGGCTGGAGCGGCCACGGTG	0.667													T	139587063	T	T	139587063	3	4	46	1	0	0	0	0	1	0	0	0	14951	768	27	1	1181	1	SOX3	23	139587063	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	3473733	139587063	15683497	69	3003											
SLITRK2	84631	broad.mit.edu	37	chrX	144906039	144906039	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtcagatgtgccaaaaccCcatctacatgcagaaggaag	11	10	2	2			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:144906039C>T	uc004fcd.2	+	5	3086	c.2096C>T	c.(2095-2097)CCC>CTC	p.P699L	SLITRK2_uc010nsp.2_Missense_Mutation_p.P699L|SLITRK2_uc010nso.2_Missense_Mutation_p.P699L|SLITRK2_uc011mwq.1_Missense_Mutation_p.P699L|SLITRK2_uc011mwr.1_Missense_Mutation_p.P699L|SLITRK2_uc011mws.1_Missense_Mutation_p.P699L|SLITRK2_uc004fcg.2_Missense_Mutation_p.P699L|SLITRK2_uc011mwt.1_Missense_Mutation_p.P699L|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	699	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TGCCAAAACCCCATCTACATG	0.478													T	144906039	T	T	144906039	3	4	46	1	0	0	0	0	1	0	0	0	14743	623	22	3	2098	3	SLITRK2	23	144906039	Missense_Mutation	SNP	C	TCGA-06-0216-01B-01D-1492-08	5318976	144906039	10364521	70	3004											
GPR50	9248	broad.mit.edu	37	chrX	150348278	150348278	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcagtctctctgtggccgatAtgctggtggccatctaccca	10	13	4	0			TCGA-06-0216-01B-01D-1492-08	TCGA-06-0216-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	eac73a02-b2e0-4601-9bd6-aceb07594fe8	1e3c9b2d-1a94-4b4b-a3e9-967c77c6498d	g.chrX:150348278A>G	uc010ntg.1	+	2	358	c.223A>G	c.(223-225)ATG>GTG	p.M75V	uc004fes.1_5'Flank|GPR50_uc011myc.1_Missense_Mutation_p.M75V	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	75	Helical; Name=2; (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TGTGGCCGATATGCTGGTGGC	0.507													G	150348278	G	G	150348278	3	3	46	1	0	0	0	0	1	0	0	0	6697	449	16	4	229	4	GPR50	23	150348278	Missense_Mutation	SNP	A	TCGA-06-0216-01B-01D-1492-08	5442239	150348278	4922282	71	3005											
OR2M4	26245	broad.mit.edu	37	chr1	248402311	248402311	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtcccacccacaccttcctTttttctctggtcctgggcat	6	16	1	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr1:248402311T>C	uc010pzh.1	+	1	81	c.81T>C	c.(79-81)CTT>CTC	p.L27L		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	27	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACACCTTCCTTTTTTCTCTGG	0.463													C	248402311	C	C	248402311	2	2	47	1	0	0	0	0	0	0	0	1	11012	1828	64	4		4	OR2M4	1	248402311	Silent	SNP	T	TCGA-06-0219-01A-01D-1491-08		248402311	848310	1	3006											
ZNF672	79894	broad.mit.edu	37	chr1	249142450	249142450	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttcagcgaccgctcggaccTcaccaagcaccggcgcacgc	10	19	2	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr1:249142450T>G	uc001iex.2	+	4	1672	c.977T>G	c.(976-978)CTC>CGC	p.L326R		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	326	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CGCTCGGACCTCACCAAGCAC	0.697													G	249142450	G	G	249142450	3	3	47	1	0	0	0	0	1	0	0	0	18076	1551	54	5	979	5	ZNF672	1	249142450	Missense_Mutation	SNP	T	TCGA-06-0219-01A-01D-1491-08	740139	249142450	108171	2	3007											
ZNF692	55657	broad.mit.edu	37	chr1	249151478	249151478	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ctcggaacaccaacttctccGagtagtatgtggaagggagg	13	9	1	0	rs141085159	byFrequency	TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr1:249151478G>T	uc001ifc.1	-	4	597	c.430C>A	c.(430-432)CGG>AGG	p.R144R	ZNF692_uc001iez.1_5'Flank|ZNF692_uc001ifa.1_5'UTR|ZNF692_uc001ifb.1_5'UTR|ZNF692_uc001ifd.1_Silent_p.R144R|ZNF692_uc001ife.1_RNA|ZNF692_uc001iff.1_Silent_p.R144R|ZNF692_uc010pzr.1_Silent_p.R149R	NM_017865	NP_060335	Q9BU19	ZN692_HUMAN	zinc finger protein 692 isoform 2	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CAACTTCTCCGAGTAGTATGT	0.547													T	249151478	T	T	249151478	2	4	47	1	0	0	0	0	0	0	0	1	18094	1057	37	5		5	ZNF692	1	249151478	Silent	SNP	G	TCGA-06-0219-01A-01D-1491-08	9028	249151478	99143	3	3008											
HS1BP3	64342	broad.mit.edu	37	chr2	20840922	20840922	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctggtaaaactcctcaatctCgctgtactttttggagacct	7	11	2	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr2:20840922C>A	uc002rdw.1	-	3	258	c.217G>T	c.(217-219)GAG>TAG	p.E73*	HS1BP3_uc002rdx.2_Nonsense_Mutation_p.E73*|HS1BP3_uc002rdy.2_Nonsense_Mutation_p.E73*	NM_022460	NP_071905	Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	73	PX.				cell communication		phosphatidylinositol binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTCAATCTCGCTGTACTTT	0.547													A	20840922	A	A	20840922	4	1	47	1	0	0	0	0	0	1	0	0	7361	893	31	5	981	5	HS1BP3	2	20840922	Nonsense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08		20840922	222358451	4	3009											
SLC4A10	57282	broad.mit.edu	37	chr2	162804208	162804208	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtcagccaccctgaagcagTtcaagactagcagatatttt	8	10	2	3			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr2:162804208T>C	uc002ubx.3	+	17	2420	c.2236T>C	c.(2236-2238)TTC>CTC	p.F746L	SLC4A10_uc002uby.3_Missense_Mutation_p.F716L|SLC4A10_uc010zcs.1_Missense_Mutation_p.F727L	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	746	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CCTGAAGCAGTTCAAGACTAG	0.383													C	162804208	C	C	162804208	3	2	47	1	0	0	0	0	1	0	0	0	14651	1725	60	4	2387	4	SLC4A10	2	162804208	Missense_Mutation	SNP	T	TCGA-06-0219-01A-01D-1491-08	141963286	162804208	80395165	5	3010											
FGD5	152273	broad.mit.edu	37	chr3	14942566	14942566	+	Frame_Shift_Del	DEL	G	-	-													ccaacgacagcatggagcaaGgggtgagtgcggcctggcgg							TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr3:14942566delG	uc003bzc.2	+	9	3372	c.3262delG	c.(3262-3264)GGGfs	p.G1088fs	FGD5_uc011avk.1_Frame_Shift_Del_p.G1088fs|FGD5_uc003bzd.2_Frame_Shift_Del_p.G166fs	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1088					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CATGGAGCAAGGGGTGAGTGC	0.642													-	14942566	-	-	14942566	7	5	47	1	0	1	0	1	0	0	0	0	5836	1000	35	0	3296	0	FGD5	3	14942566	Frame_Shift_Del	DEL	G	TCGA-06-0219-01A-01D-1491-08		14942566	183079864	6	3011											
RPL15	6138	broad.mit.edu	37	chr3	23959481	23959481	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagggctccccgccccacccGgcctgataaagcgcgccgac	11	20	0	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr3:23959481G>A	uc003ccn.2	+	2	167	c.131G>A	c.(130-132)CGG>CAG	p.R44Q	NKIRAS1_uc003cck.2_Intron|NKIRAS1_uc003ccj.2_5'Flank|NKIRAS1_uc003ccl.2_5'Flank|NKIRAS1_uc003ccm.2_5'Flank|RPL15_uc011awi.1_Missense_Mutation_p.R44Q|RPL15_uc011awj.1_Missense_Mutation_p.R44Q|RPL15_uc003cco.2_Missense_Mutation_p.R44Q|RPL15_uc003ccp.2_Missense_Mutation_p.R44Q|RPL15_uc003ccq.2_Missense_Mutation_p.R44Q|RPL15_uc003ccr.2_Missense_Mutation_p.R44Q	NM_002948	NP_002939	P61313	RL15_HUMAN	ribosomal protein L15	44					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			ovary(1)	1						CGCCCCACCCGGCCTGATAAA	0.557													A	23959481	A	A	23959481	3	1	47	1	0	0	0	0	1	0	0	0	13562	1116	39	2	133	2	RPL15	3	23959481	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08	9016915	23959481	174062949	7	3012											
TRAT1	50852	broad.mit.edu	37	chr3	108568057	108568057	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aacaaatgaaagcccgaccaGagaaatctgtaaataagatg	8	7	1	3			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr3:108568057G>T	uc003dxi.1	+	5	403	c.259G>T	c.(259-261)GAG>TAG	p.E87*	TRAT1_uc010hpx.1_Nonsense_Mutation_p.E50*	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	87	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						AGCCCGACCAGAGAAATCTGT	0.353													T	108568057	T	T	108568057	4	4	47	1	0	0	0	0	0	1	0	0	16463	943	33	5	277	5	TRAT1	3	108568057	Nonsense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08	84608576	108568057	89454373	8	3013											
UROC1	131669	broad.mit.edu	37	chr3	126236443	126236443	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggcccactgcttacctgtttCtccacagggctgaggctggg	13	13	1	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr3:126236443C>T	uc003eiz.1	-	1	152	c.120G>A	c.(118-120)GAG>GAA	p.E40E	UROC1_uc010hsi.1_Silent_p.E40E	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	40					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		TTACCTGTTTCTCCACAGGGC	0.677													T	126236443	T	T	126236443	2	4	47	1	0	0	0	0	0	0	0	1	17025	912	32	3		3	UROC1	3	126236443	Silent	SNP	C	TCGA-06-0219-01A-01D-1491-08	17668386	126236443	71785987	9	3014											
CLCN2	1181	broad.mit.edu	37	chr3	184071135	184071135	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgcatgtgctgccgccggCgggctgggctcagctgggcc	17	15	1	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr3:184071135C>T	uc003foi.2	-	17	2055	c.1931G>A	c.(1930-1932)CGC>CAC	p.R644H	CLCN2_uc003foh.2_Missense_Mutation_p.R168H|CLCN2_uc010hya.1_Missense_Mutation_p.R627H|CLCN2_uc011brl.1_Missense_Mutation_p.R644H|CLCN2_uc011brm.1_Missense_Mutation_p.R600H	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	644	Cytoplasmic (By similarity).		R -> C (no effect).			chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	CTGCCGCCGGCGGGCTGGGCT	0.627													T	184071135	T	T	184071135	3	4	47	1	0	0	0	0	1	0	0	0	3463	768	27	1	797	1	CLCN2	3	184071135	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	57834692	184071135	13951295	10	3015											
LPP	4026	broad.mit.edu	37	chr3	188327129	188327129	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gaacactcaaaccccagcctCagccagtcccagcctcctac	5	20	2	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr3:188327129C>T	uc003frs.1	+	6	856	c.610C>T	c.(610-612)CAG>TAG	p.Q204*	LPP_uc011bsg.1_Nonsense_Mutation_p.Q204*|LPP_uc011bsi.1_Nonsense_Mutation_p.Q204*|LPP_uc003frt.2_Nonsense_Mutation_p.Q204*|LPP_uc011bsj.1_Nonsense_Mutation_p.Q41*	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	204	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		ACCCCAGCCTCAGCCAGTCCC	0.567			T	HMGA2|MLL|C12orf9	lipoma|leukemia								T	188327129	T	T	188327129	4	4	47	1	0	0	0	0	0	1	0	0	8923	827	29	3	624	3	LPP	3	188327129	Nonsense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	4255994	188327129	9695301	11	3016											
ZNF518B	85460	broad.mit.edu	37	chr4	10445311	10445311	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tacttatagaaagacttctgGaaagcagtctcccttgctta	7	9	2	2			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr4:10445311G>T	uc003gmn.2	-	3	3129	c.2642C>A	c.(2641-2643)TCC>TAC	p.S881Y		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	881					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						AAGACTTCTGGAAAGCAGTCT	0.403													T	10445311	T	T	10445311	3	4	47	1	0	0	0	0	1	0	0	0	17960	1174	41	5	586	5	ZNF518B	4	10445311	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08		10445311	180708965	12	3017											
PRDM9	56979	broad.mit.edu	37	chr5	23527628	23527628	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtctgcagggagtgtgggCggggctttagcaataagtca	16	6	2	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr5:23527628C>T	uc003jgo.2	+	11	2613	c.2431C>T	c.(2431-2433)CGG>TGG	p.R811W		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	811	C2H2-type 12.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGAGTGTGGGCGGGGCTTTAG	0.572										HNSCC(3;0.000094)			T	23527628	T	T	23527628	3	4	47	1	0	0	0	0	1	0	0	0	12463	759	27	1	2469	1	PRDM9	5	23527628	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08		23527628	157387632	13	3018											
TRIM23	373	broad.mit.edu	37	chr5	64887666	64887666	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaacccttcatacagtcccAtaccacttcgagcatcacag	4	17	2	0	rs150920611		TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr5:64887666A>G	uc003jty.2	-	11	1741	c.1655T>C	c.(1654-1656)ATG>ACG	p.M552T	TRIM23_uc003jtw.2_Intron|TRIM23_uc003jtx.2_Intron	NM_001656	NP_001647	P36406	TRI23_HUMAN	ADP-ribosylation factor domain protein 1 isoform	552	ARF-like.				interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		ATACAGTCCCATACCACTTCG	0.458													G	64887666	G	G	64887666	3	3	47	1	0	0	0	0	1	0	0	0	16494	217	8	4	140	4	TRIM23	5	64887666	Missense_Mutation	SNP	A	TCGA-06-0219-01A-01D-1491-08	41360038	64887666	116027594	14	3019											
SLCO6A1	133482	broad.mit.edu	37	chr5	101834438	101834438	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcttcgaggacttcggggtTcccttggccctcctgtcctt	12	14	0	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr5:101834438T>C	uc003knn.2	-	1	283	c.111A>G	c.(109-111)GGA>GGG	p.G37G	SLCO6A1_uc003kno.2_Silent_p.G37G|SLCO6A1_uc003knp.2_Silent_p.G37G|SLCO6A1_uc003knq.2_Silent_p.G37G	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	37	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		ACTTCGGGGTTCCCTTGGCCC	0.602													C	101834438	C	C	101834438	2	2	47	1	0	0	0	0	0	0	0	1	14732	1770	62	4		4	SLCO6A1	5	101834438	Silent	SNP	T	TCGA-06-0219-01A-01D-1491-08	36946772	101834438	79080822	15	3020											
PCDHGA2	56113	broad.mit.edu	37	chr5	140719925	140719925	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctactccacctacattcccGaaaacaaccccagaggagcc	5	18	0	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr5:140719925G>A	uc003ljk.1	+	1	1572	c.1387G>A	c.(1387-1389)GAA>AAA	p.E463K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.E463K	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	463	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACATTCCCGAAAACAACCC	0.562													A	140719925	A	A	140719925	3	1	47	1	0	0	0	0	1	0	0	0	11554	1059	37	2	1389	2	PCDHGA2	5	140719925	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08	38885487	140719925	40195335	16	3021											
COL11A2	1302	broad.mit.edu	37	chr6	33152017	33152017	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ataggtgtaatcgtagggccCttcaggggggtctgtgccac	15	9	2	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr6:33152017C>A	uc003ocx.1	-	8	1252	c.1024G>T	c.(1024-1026)GGG>TGG	p.G342W	COL11A2_uc003ocy.1_Intron|COL11A2_uc003ocz.1_Intron	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	342	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TCGTAGGGCCCTTCAGGGGGG	0.612													A	33152017	A	A	33152017	3	1	47	1	0	0	0	0	1	0	0	0	3668	681	24	5	4422	5	COL11A2	6	33152017	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08		33152017	137963050	17	3022											
C6orf167	253714	broad.mit.edu	37	chr6	97702431	97702431	+	Splice_Site	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttttaaaaaatgaagtcttAccatttcatctggtactcca	4	8	3	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr6:97702431A>C	uc003ppb.2	-	10	1385	c.1119_splice	c.e10+1	p.M373_splice	C6orf167_uc011eaf.1_Splice_Site_p.M373_splice|C6orf167_uc010kcn.1_Splice_Site_p.M147_splice|C6orf167_uc010kco.1_Splice_Site_p.M109_splice|C6orf167_uc003ppc.2_Missense_Mutation_p.V374G	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714						double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		ATGAAGTCTTACCATTTCATC	0.313													C	97702431	C	C	97702431	5	2	47	1	0	0	0	0	0	0	1	0	2342	405	14	5	2674	5	C6orf167	6	97702431	Splice_Site	SNP	A	TCGA-06-0219-01A-01D-1491-08	64550414	97702431	73412636	18	3023											
RSBN1L	222194	broad.mit.edu	37	chr7	77408002	77408002	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgtatgcagtttagcatgGcatattcggctcaaattata	9	7	1	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr7:77408002G>A	uc010ldt.1	+	8	2102	c.2058G>A	c.(2056-2058)TGG>TGA	p.W686*	RSBN1L_uc003ugm.2_Nonsense_Mutation_p.W468*	NM_198467	NP_940869	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	686						nucleus				ovary(1)	1						GTTTAGCATGGCATATTCGGC	0.388													A	77408002	A	A	77408002	4	1	47	1	0	0	0	0	0	1	0	0	13697	1212	42	3	2088	3	RSBN1L	7	77408002	Nonsense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08		77408002	81730661	19	3024											
TSGA13	114960	broad.mit.edu	37	chr7	130365809	130365809	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggatggactgtgtaatgcCgaaggttctctagaacaaat	11	6	1	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr7:130365809C>T	uc003vqi.2	-	4	606	c.149G>A	c.(148-150)CGG>CAG	p.R50Q	TSGA13_uc003vqj.2_Missense_Mutation_p.R50Q	NM_052933	NP_443165	Q96PP4	TSG13_HUMAN	testis specific, 13	50										ovary(2)	2	Melanoma(18;0.0435)					TGTGTAATGCCGAAGGTTCTC	0.433													T	130365809	T	T	130365809	3	4	47	1	0	0	0	0	1	0	0	0	16616	652	23	2	698	2	TSGA13	7	130365809	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	52957807	130365809	28772854	20	3025											
MLL3	58508	broad.mit.edu	37	chr7	151962220	151962220	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cattccatgatagtgctgacCacaagtagtacaaaagaact	7	9	0	3			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr7:151962220C>A	uc003wla.2	-	8	1306	c.1087G>T	c.(1087-1089)GGT>TGT	p.G363C		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	363	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TAGTGCTGACCACAAGTAGTA	0.448			N		medulloblastoma								A	151962220	A	A	151962220	3	1	47	1	0	0	0	0	1	0	0	0	9622	594	21	5	13856	5	MLL3	7	151962220	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	21596411	151962220	7176443	21	3026											
ADAM7	8756	broad.mit.edu	37	chr8	24339684	24339684	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accttaaacatccatgtgacGttggttggcattgaaatatg	9	7	0	2	rs147649440		TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr8:24339684G>A	uc003xeb.2	+	9	848	c.735G>A	c.(733-735)ACG>ACA	p.T245T	ADAM7_uc003xec.2_Silent_p.T17T	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	245	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TCCATGTGACGTTGGTTGGCA	0.303													A	24339684	A	A	24339684	2	1	47	1	0	0	0	0	0	0	0	1	251	1132	40	1		1	ADAM7	8	24339684	Silent	SNP	G	TCGA-06-0219-01A-01D-1491-08		24339684	122024338	22	3027											
OPRK1	4986	broad.mit.edu	37	chr8	54163341	54163341	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcgctgtccccgcgctcacCggatgatcacgaacatgacc	10	16	2	2			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr8:54163341C>T	uc003xrh.1	-	1	632	c.257G>A	c.(256-258)CGA>CAA	p.R86Q	OPRK1_uc003xri.1_Missense_Mutation_p.R86Q|OPRK1_uc010lyc.1_5'UTR	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	86	Cytoplasmic (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CCGCGCTCACCGGATGATCAC	0.682													T	54163341	T	T	54163341	3	4	47	1	0	0	0	0	1	0	0	0	10885	666	23	2	897	2	OPRK1	8	54163341	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	29823657	54163341	92200681	23	3028											
KCNS2	3788	broad.mit.edu	37	chr8	99441436	99441436	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctgcccatcaccttgatctTcaataagttctcccactttt	3	15	4	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr8:99441436T>C	uc003yin.2	+	2	1579	c.1229T>C	c.(1228-1230)TTC>TCC	p.F410S		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	410	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			ACCTTGATCTTCAATAAGTTC	0.552													C	99441436	C	C	99441436	3	2	47	1	0	0	0	0	1	0	0	0	8089	1783	62	4	1231	4	KCNS2	8	99441436	Missense_Mutation	SNP	T	TCGA-06-0219-01A-01D-1491-08	45278095	99441436	46922586	24	3029											
CSMD3	114788	broad.mit.edu	37	chr8	113256758	113256758	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatggaaggtccatccctaCgacatttgcatgagcaggag	12	9	0	2			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr8:113256758C>T	uc003ynu.2	-	65	10426	c.10267G>A	c.(10267-10269)GTA>ATA	p.V3423I	CSMD3_uc003yns.2_Missense_Mutation_p.V2625I|CSMD3_uc003ynt.2_Missense_Mutation_p.V3383I|CSMD3_uc011lhx.1_Missense_Mutation_p.V3254I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3423	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane		p.V3423I(1)		ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCCATCCCTACGACATTTGCA	0.393										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			T	113256758	T	T	113256758	3	4	47	1	0	0	0	0	1	0	0	0	3946	536	19	1	884	1	CSMD3	8	113256758	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	13815322	113256758	33107264	25	3030											
FER1L6	654463	broad.mit.edu	37	chr8	125047530	125047530	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctccagcctcctgggaaaCgaccggctggttggtctgtg	13	12	2	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr8:125047530C>T	uc003yqw.2	+	19	2505	c.2299C>T	c.(2299-2301)CGA>TGA	p.R767*	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	767	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCCTGGGAAACGACCGGCTGG	0.493													T	125047530	T	T	125047530	4	4	47	1	0	0	0	0	0	1	0	0	5815	528	19	1	2369	1	FER1L6	8	125047530	Nonsense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	11790772	125047530	21316492	26	3031											
EPPK1	83481	broad.mit.edu	37	chr8	144940504	144940504	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtcggtgtagccggtgacGgcgcgctcggccgacagcag	19	12	0	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr8:144940504G>A	uc003zaa.1	-	2	14941	c.14928C>T	c.(14926-14928)GCC>GCT	p.A4976A		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4976	Plectin 63.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGCCGGTGACGGCGCGCTCGG	0.701													A	144940504	A	A	144940504	2	1	47	1	0	0	0	0	0	0	0	1	5190	1103	39	2		2	EPPK1	8	144940504	Silent	SNP	G	TCGA-06-0219-01A-01D-1491-08	19892974	144940504	1423518	27	3032											
FRMD3	257019	broad.mit.edu	37	chr9	85924522	85924522	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgttgaagtatggaaTgccaacatggcttttttcta	11	6	1	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr9:85924522T>C	uc004ams.1	-	10	1057	c.855A>G	c.(853-855)GCA>GCG	p.A285A	FRMD3_uc004amr.1_Silent_p.A271A	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	285	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						AAGTATGGAATGCCAACATGG	0.333													C	85924522	C	C	85924522	2	2	47	1	0	0	0	0	0	0	0	1	6050	1451	51	4		4	FRMD3	9	85924522	Silent	SNP	T	TCGA-06-0219-01A-01D-1491-08		85924522	55288909	28	3033											
CYLC2	1539	broad.mit.edu	37	chr9	105767700	105767700	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aatcgaaggatgccaagaaaGatgcaaaggagattaaaaaa	10	4	0	3			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr9:105767700G>T	uc004bbs.2	+	5	857	c.787G>T	c.(787-789)GAT>TAT	p.D263Y		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	263	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				TGCCAAGAAAGATGCAAAGGA	0.318													T	105767700	T	T	105767700	3	4	47	1	0	0	0	0	1	0	0	0	4142	942	33	5	805	5	CYLC2	9	105767700	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08	19843178	105767700	35445731	29	3034											
LIPK	643414	broad.mit.edu	37	chr10	90497505	90497505	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcagcaacttcctatttacTctgagtggatttgatccgca	8	10	1	2			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr10:90497505T>C	uc010qmv.1	+	6	783	c.783T>C	c.(781-783)ACT>ACC	p.T261T		NM_001080518	NP_001073987	Q5VXJ0	LIPK_HUMAN	lipase, family member K precursor	261					lipid catabolic process	extracellular region	hydrolase activity			ovary(2)	2		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		TCCTATTTACTCTGAGTGGAT	0.383													C	90497505	C	C	90497505	2	2	47	1	0	0	0	0	0	0	0	1	8827	1538	54	4		4	LIPK	10	90497505	Silent	SNP	T	TCGA-06-0219-01A-01D-1491-08		90497505	45037242	30	3035											
MUC5B	727897	broad.mit.edu	37	chr11	1272821	1272821	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccaccgtggggaccacccGcacccctgcagtgctcccca	10	20	0	0	rs56353324		TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr11:1272821G>A	uc009ycr.1	+	52	15803	c.15677G>A	c.(15676-15678)CGC>CAC	p.R5226H	MUC5B_uc001ltb.2_Missense_Mutation_p.R4907H	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4904	Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGGACCACCCGCACCCCTGCA	0.652													A	1272821	A	A	1272821	3	1	47	1	0	0	0	0	1	0	0	0	9979	1087	38	1	14842	1	MUC5B	11	1272821	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08		1272821	133733695	31	3036											
OR51D1	390038	broad.mit.edu	37	chr11	4661423	4661423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctggccatggcttttgacCgctttgtggccatttgccac	11	12	0	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr11:4661423C>T	uc010qyk.1	+	1	403	c.403C>T	c.(403-405)CGC>TGC	p.R135C		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCTTTTGACCGCTTTGTGGC	0.542													T	4661423	T	T	4661423	3	4	47	1	0	0	0	0	1	0	0	0	11093	652	23	2	405	2	OR51D1	11	4661423	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	3388602	4661423	130345093	32	3037											
RBMXL2	27288	broad.mit.edu	37	chr11	7110545	7110545	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccgcagacgccaaggccgCcgccagagacatgaacggca	12	17	0	3			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr11:7110545C>T	uc001mfc.2	+	1	381	c.194C>T	c.(193-195)GCC>GTC	p.A65V		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	65	RRM.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCCAAGGCCGCCGCCAGAGAC	0.647													T	7110545	T	T	7110545	3	4	47	1	0	0	0	0	1	0	0	0	13154	739	26	3	196	3	RBMXL2	11	7110545	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	2449122	7110545	127895971	33	3038											
SLC17A6	57084	broad.mit.edu	37	chr11	22391734	22391734	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttggatttgaaattagcaaGgtatgtaaaatgtattctta	8	2	1	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr11:22391734G>C	uc001mqk.2	+	8	1454	c.1041G>C	c.(1039-1041)AAG>AAC	p.K347N		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	347	Vesicular (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						AAATTAGCAAGGTATGTAAAA	0.279													C	22391734	C	C	22391734	3	2	47	1	0	0	0	0	1	0	0	0	14421	1014	35	5	1071	5	SLC17A6	11	22391734	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08	15281189	22391734	112614782	34	3039											
MPEG1	219972	broad.mit.edu	37	chr11	58978613	58978613	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagcccggatttgacgcaatAggacacttggcatccatcgc	11	12	0	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr11:58978613A>G	uc001nnu.3	-	1	1882	c.1726T>C	c.(1726-1728)TAT>CAT	p.Y576H		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	576	Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				TTGACGCAATAGGACACTTGG	0.602													G	58978613	G	G	58978613	3	3	47	1	0	0	0	0	1	0	0	0	9723	420	15	4	428	4	MPEG1	11	58978613	Missense_Mutation	SNP	A	TCGA-06-0219-01A-01D-1491-08	36586879	58978613	76027903	35	3040											
KCNJ8	3764	broad.mit.edu	37	chr12	21918727	21918727	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttggtaccatgagggaagaaTtgttccttcggatagaattg	12	5	0	3			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr12:21918727T>C	uc001rff.2	-	3	1543	c.1205A>G	c.(1204-1206)AAT>AGT	p.N402S		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	402	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	GAGGGAAGAATTGTTCCTTCG	0.408													C	21918727	C	C	21918727	3	2	47	1	0	0	0	0	1	0	0	0	8056	1493	52	4	73	4	KCNJ8	12	21918727	Missense_Mutation	SNP	T	TCGA-06-0219-01A-01D-1491-08		21918727	111933168	36	3041											
NTN4	59277	broad.mit.edu	37	chr12	96052972	96052972	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tttgcctgttcttatatcctCatgtcctgctacaaggtatt	6	10	2	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr12:96052972C>T	uc001tei.2	-	10	2226	c.1777G>A	c.(1777-1779)GAG>AAG	p.E593K	NTN4_uc009ztf.2_Missense_Mutation_p.E570K|NTN4_uc009ztg.2_Missense_Mutation_p.E556K	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	593	NTR.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CTTATATCCTCATGTCCTGCT	0.368													T	96052972	T	T	96052972	3	4	47	1	0	0	0	0	1	0	0	0	10702	835	29	3	113	3	NTN4	12	96052972	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	74134245	96052972	37798923	37	3042											
GLT8D2	83468	broad.mit.edu	37	chr12	104390581	104390581	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcatctgagaaagccgccgCgtggcccagggccaaggtgg	16	12	2	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr12:104390581C>T	uc001tkh.1	-	8	938	c.532G>A	c.(532-534)GCG>ACG	p.A178T	GLT8D2_uc001tki.1_Missense_Mutation_p.A178T	NM_031302	NP_112592	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	178	Lumenal (Potential).					integral to membrane	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2						AAAGCCGCCGCGTGGCCCAGG	0.478													T	104390581	T	T	104390581	3	4	47	1	0	0	0	0	1	0	0	0	6470	768	27	1	533	1	GLT8D2	12	104390581	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	8337609	104390581	29461314	38	3043											
ACACB	32	broad.mit.edu	37	chr12	109696853	109696853	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggccgtcaaggacttcaacCgggagaagttgcccctgatg	13	11	2	2			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr12:109696853C>T	uc001tob.2	+	47	6555	c.6436C>T	c.(6436-6438)CGG>TGG	p.R2146W	ACACB_uc001toc.2_Missense_Mutation_p.R2146W|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.R812W	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2146	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGACTTCAACCGGGAGAAGTT	0.572													T	109696853	T	T	109696853	3	4	47	1	0	0	0	0	1	0	0	0	107	643	23	2	6618	2	ACACB	12	109696853	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	5306272	109696853	24155042	39	3044											
ACAD10	80724	broad.mit.edu	37	chr12	112182642	112182642	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cacaggcagcaggagttataGctccgttccagaagcttccc	10	13	0	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr12:112182642G>C	uc001tsq.2	+	13	2110	c.1910G>C	c.(1909-1911)AGC>ACC	p.S637T	ACAD10_uc001tsp.2_Missense_Mutation_p.S637T|ACAD10_uc009zvx.2_Missense_Mutation_p.S668T|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	637							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						AGGAGTTATAGCTCCGTTCCA	0.562													C	112182642	C	C	112182642	3	2	47	1	0	0	0	0	1	0	0	0	108	971	34	5	2053	5	ACAD10	12	112182642	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08	2485789	112182642	21669253	40	3045											
NUFIP1	26747	broad.mit.edu	37	chr13	45554922	45554922	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaaaccacgatcacaggtatCacaaaaaaagtgaaaaactg	6	8	2	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr13:45554922C>T	uc001uzp.2	-	3	571	c.529G>A	c.(529-531)GAT>AAT	p.D177N		NM_012345	NP_036477	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein	177	C2H2-type.				box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding				0		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		TCACAGGTATCACAAAAAAAG	0.313													T	45554922	T	T	45554922	3	4	47	1	0	0	0	0	1	0	0	0	10748	826	29	3	990	3	NUFIP1	13	45554922	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08		45554922	69614956	41	3046											
ESRRB	2103	broad.mit.edu	37	chr14	76905790	76905790	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggcatcgatgccctcagcCaccacagccccagtggctcg	11	18	1	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr14:76905790C>T	uc001xsq.1	+	2	161	c.94C>T	c.(94-96)CAC>TAC	p.H32Y	ESRRB_uc001xsr.2_Missense_Mutation_p.H32Y|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	32						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		TGCCCTCAGCCACCACAGCCC	0.682													T	76905790	T	T	76905790	3	4	47	1	0	0	0	0	1	0	0	0	5261	594	21	3	96	3	ESRRB	14	76905790	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08		76905790	30443750	42	3047											
RYR3	6263	broad.mit.edu	37	chr15	34130561	34130561	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcttacgtgttagaaattgCgggtgaagaggaagaagacg	14	4	1	5			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr15:34130561C>T	uc001zhi.2	+	89	12450	c.12380C>T	c.(12379-12381)GCG>GTG	p.A4127V	RYR3_uc010bar.2_Missense_Mutation_p.A4122V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4127					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTAGAAATTGCGGGTGAAGAG	0.483													T	34130561	T	T	34130561	3	4	47	1	0	0	0	0	1	0	0	0	13770	768	27	1	12734	1	RYR3	15	34130561	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08		34130561	68400831	43	3048											
AMAC1	146861	broad.mit.edu	37	chr17	33521189	33521189	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagccagcaggcaggcccccAcccagcagggccaccagcag	12	18	0	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr17:33521189A>C	uc002hjd.2	-	1	224	c.138T>G	c.(136-138)GGT>GGG	p.G46G		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	46	Helical; (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		GCAGGCCCCCACCCAGCAGGG	0.682													C	33521189	C	C	33521189	2	2	47	1	0	0	0	0	0	0	0	1	559	146	6	5		5	AMAC1	17	33521189	Silent	SNP	A	TCGA-06-0219-01A-01D-1491-08		33521189	47674021	44	3049											
CDC42EP4	23580	broad.mit.edu	37	chr17	71282053	71282053	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgcttcagcccgtacgtgGccttgggcacgacaggcaga	13	13	1	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr17:71282053G>A	uc002jjn.2	-	2	734	c.587C>T	c.(586-588)GCC>GTC	p.A196V	CDC42EP4_uc002jjo.2_Missense_Mutation_p.A196V|CDC42EP4_uc002jjp.1_Missense_Mutation_p.A126V	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	196					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			CCCGTACGTGGCCTTGGGCAC	0.632													A	71282053	A	A	71282053	3	1	47	1	0	0	0	0	1	0	0	0	3078	1203	42	3	487	3	CDC42EP4	17	71282053	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08	37760864	71282053	9913157	45	3050											
EPB41L3	23136	broad.mit.edu	37	chr18	5428421	5428421	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggtcgcgatatatcaacagaCcacttgcacaaactcctaac	6	13	1	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr18:5428421C>G	uc002kmt.1	-	9	1042	c.956G>C	c.(955-957)GGT>GCT	p.G319A	EPB41L3_uc010wzh.1_Missense_Mutation_p.G319A|EPB41L3_uc002kmu.1_Missense_Mutation_p.G319A|EPB41L3_uc010dkq.1_Missense_Mutation_p.G210A|EPB41L3_uc010dks.1_Missense_Mutation_p.G341A	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	319	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TATCAACAGACCACTTGCACA	0.393													G	5428421	G	G	5428421	3	3	47	1	0	0	0	0	1	0	0	0	5154	507	18	5	2363	5	EPB41L3	18	5428421	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08		5428421	72648827	46	3051											
ATCAY	85300	broad.mit.edu	37	chr19	3907818	3907818	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgacggaggacggcagcgccGccaacgggcgcctgtggcgg	19	14	0	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr19:3907818G>A	uc002lyy.3	+	5	875	c.445G>A	c.(445-447)GCC>ACC	p.A149T	ATCAY_uc010xhz.1_Missense_Mutation_p.A155T|ATCAY_uc010dts.2_5'Flank	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	149					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		CGGCAGCGCCGCCAACGGGCG	0.642													A	3907818	A	A	3907818	3	1	47	1	0	0	0	0	1	0	0	0	1077	1087	38	1	459	1	ATCAY	19	3907818	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08		3907818	55221165	47	3052											
ZNF536	9745	broad.mit.edu	37	chr19	30935903	30935903	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cccatctccagcatggcccaCggcgtcccggagggggacaa	13	16	1	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr19:30935903C>G	uc002nsu.1	+	2	1572	c.1434C>G	c.(1432-1434)CAC>CAG	p.H478Q	ZNF536_uc010edd.1_Missense_Mutation_p.H478Q	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCATGGCCCACGGCGTCCCGG	0.662													G	30935903	G	G	30935903	3	3	47	1	0	0	0	0	1	0	0	0	17971	535	19	5	1436	5	ZNF536	19	30935903	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	27028085	30935903	28193080	48	3053											
MLL4	9757	broad.mit.edu	37	chr19	36214780	36214780	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	agggcccgaggagcaggactCcctcctgcagcgcaagtcag	14	14	1	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr19:36214780C>G	uc010eei.2	+	9	3206	c.3206C>G	c.(3205-3207)TCC>TGC	p.S1069C		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1069					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGCAGGACTCCCTCCTGCAG	0.716													G	36214780	G	G	36214780	3	3	47	1	0	0	0	0	1	0	0	0	9623	855	30	5	3236	5	MLL4	19	36214780	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08	5278877	36214780	22914203	49	3054											
MARK4	57787	broad.mit.edu	37	chr19	45774954	45774954	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctccctgcccttcgacggGcacaacctcaaggtaccgag	11	16	1	0			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr19:45774954G>A	uc002pbb.1	+	8	779	c.774G>A	c.(772-774)GGG>GGA	p.G258G	MARK4_uc002paz.1_Missense_Mutation_p.G69D|MARK4_uc002pba.1_Silent_p.G258G|MARK4_uc002pbc.1_Silent_p.G124G			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	258	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCTTCGACGGGCACAACCTCA	0.657													A	45774954	A	A	45774954	2	1	47	1	0	0	0	0	0	0	0	1	9315	1190	42	3		3	MARK4	19	45774954	Silent	SNP	G	TCGA-06-0219-01A-01D-1491-08	9560174	45774954	13354029	50	3055											
SIGLEC6	946	broad.mit.edu	37	chr19	52034451	52034451	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcttggaagatgtataaccGtatttcatccatttggactt	8	7	1	1			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr19:52034451G>A	uc002pwy.2	-	2	552	c.390C>T	c.(388-390)TAC>TAT	p.Y130Y	SIGLEC6_uc002pwz.2_Silent_p.Y130Y|SIGLEC6_uc002pxa.2_Silent_p.Y130Y|SIGLEC6_uc010ydb.1_Silent_p.Y83Y|SIGLEC6_uc010ydc.1_Silent_p.Y119Y|SIGLEC6_uc010eoz.1_Silent_p.Y119Y|SIGLEC6_uc010epb.1_Silent_p.Y83Y|SIGLEC6_uc010epa.1_Silent_p.Y119Y	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	130	Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		ATGTATAACCGTATTTCATCC	0.547													A	52034451	A	A	52034451	2	1	47	1	0	0	0	0	0	0	0	1	14312	1140	40	1		1	SIGLEC6	19	52034451	Silent	SNP	G	TCGA-06-0219-01A-01D-1491-08	6259497	52034451	7094532	51	3056											
C20orf152	140894	broad.mit.edu	37	chr20	34572591	34572591	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtgaggaggtccaccatcGtctgtatggaagaaacggag	14	8	1	2			TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chr20:34572591G>A	uc002xes.1	+	6	763	c.607G>A	c.(607-609)GTC>ATC	p.V203I	C20orf152_uc002xer.1_Missense_Mutation_p.V203I|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	203	cNMP.										0	Breast(12;0.00631)					GTCCACCATCGTCTGTATGGA	0.527													A	34572591	A	A	34572591	3	1	47	1	0	0	0	0	1	0	0	0	2092	1145	40	1	629	1	C20orf152	20	34572591	Missense_Mutation	SNP	G	TCGA-06-0219-01A-01D-1491-08		34572591	28452929	52	3057											
MXRA5	25878	broad.mit.edu	37	chrX	3235658	3235658	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctggccacgcacttatagaCgcctctgtctgagaaggacg	12	12	2	2	rs140532419	byFrequency	TCGA-06-0219-01A-01D-1491-08	TCGA-06-0219-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c6c454-058f-41ec-93c3-3cff44bed149	83f3feb7-bc3d-4ee4-bcee-4babe9446508	g.chrX:3235658C>T	uc004crg.3	-	6	6221	c.6064G>A	c.(6064-6066)GTC>ATC	p.V2022I		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2022	Ig-like C2-type 4.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CACTTATAGACGCCTCTGTCT	0.642													T	3235658	T	T	3235658	3	4	47	1	0	0	0	0	1	0	0	0	10003	536	19	1	2430	1	MXRA5	23	3235658	Missense_Mutation	SNP	C	TCGA-06-0219-01A-01D-1491-08		3235658	152034902	53	3058											
AGRN	375790	broad.mit.edu	37	chr1	978952	978952	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccgctttggagccctgtgCgaggccgagaccgggcgctg	17	13	0	1	rs142440782		TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr1:978952C>T	uc001ack.1	+	9	1688	c.1638C>T	c.(1636-1638)TGC>TGT	p.C546C		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	546	Kazal-like 6.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GAGCCCTGTGCGAGGCCGAGA	0.692													T	978952	T	T	978952	2	4	48	1	0	0	0	0	0	0	0	1	397	776	27	1		1	AGRN	1	978952	Silent	SNP	C	TCGA-06-0237-01A-02D-1491-08		978952	248271669	1	3059											
GALE	2582	broad.mit.edu	37	chr1	24125491	24125491	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	acctgttaccagcaccttctCtgccatggcacctggcccag	8	17	1	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr1:24125491C>G	uc009vqo.1	-	2	217	c.7G>C	c.(7-9)GAG>CAG	p.E3Q	GALE_uc001bhv.1_Missense_Mutation_p.E3Q|GALE_uc001bhw.1_Missense_Mutation_p.E3Q|GALE_uc001bhx.1_Missense_Mutation_p.E3Q|GALE_uc009vqp.1_Missense_Mutation_p.E3Q|GALE_uc001bhy.1_Missense_Mutation_p.E3Q|GALE_uc001bhz.1_Intron|GALE_uc001bia.2_5'Flank|GALE_uc009vqq.1_Missense_Mutation_p.E3Q	NM_001127621	NP_001121093	Q14376	GALE_HUMAN	UDP-galactose-4-epimerase	3					galactose catabolic process	cytosol	coenzyme binding|protein homodimerization activity|UDP-glucose 4-epimerase activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		AGCACCTTCTCTGCCATGGCA	0.592													G	24125491	G	G	24125491	3	3	48	1	0	0	0	0	1	0	0	0	6202	922	32	5	1079	5	GALE	1	24125491	Missense_Mutation	SNP	C	TCGA-06-0237-01A-02D-1491-08	23146539	24125491	225125130	2	3060											
USH2A	7399	broad.mit.edu	37	chr1	215933077	215933077	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaaagcaagtttccattaCgactcaattgatattgagaa	8	6	1	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr1:215933077C>T	uc001hku.1	-	57	11543	c.11156G>A	c.(11155-11157)CGT>CAT	p.R3719H		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3719	Fibronectin type-III 22.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTTCCATTACGACTCAATTG	0.408										HNSCC(13;0.011)			T	215933077	T	T	215933077	3	4	48	1	0	0	0	0	1	0	0	0	17033	536	19	1	4516	1	USH2A	1	215933077	Missense_Mutation	SNP	C	TCGA-06-0237-01A-02D-1491-08	191807586	215933077	33317544	3	3061											
OBSCN	84033	broad.mit.edu	37	chr1	228494689	228494689	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgctgcgagctgagccgggCgggtgcgagcgtggagtggc	21	9	0	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr1:228494689C>T	uc009xez.1	+	45	12058	c.12014C>T	c.(12013-12015)GCG>GTG	p.A4005V	OBSCN_uc001hsn.2_Missense_Mutation_p.A4005V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4005	Ig-like 41.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTGAGCCGGGCGGGTGCGAGC	0.657													T	228494689	T	T	228494689	3	4	48	1	0	0	0	0	1	0	0	0	10812	768	27	1	12188	1	OBSCN	1	228494689	Missense_Mutation	SNP	C	TCGA-06-0237-01A-02D-1491-08	12561612	228494689	20755932	4	3062											
RYR2	6262	broad.mit.edu	37	chr1	237813234	237813234	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcggtacctttgcacagccGtcttgccattgttaacaaga	8	11	1	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr1:237813234G>A	uc001hyl.1	+	50	7690	c.7570G>A	c.(7570-7572)GTC>ATC	p.V2524I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2524	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTGCACAGCCGTCTTGCCATT	0.463													A	237813234	A	A	237813234	3	1	48	1	0	0	0	0	1	0	0	0	13769	1145	40	1	7768	1	RYR2	1	237813234	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	9318545	237813234	11437387	5	3063											
FOXD4L1	200350	broad.mit.edu	37	chr2	114257073	114257073	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcgagggcggcggcccgagCgacccctcagagtttggcac	15	14	1	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr2:114257073C>T	uc002tjw.3	+	1	413	c.240C>T	c.(238-240)AGC>AGT	p.S80S		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	80					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GCGGCCCGAGCGACCCCTCAG	0.697													T	114257073	T	T	114257073	2	4	48	1	0	0	0	0	0	0	0	1	6000	767	27	1		1	FOXD4L1	2	114257073	Silent	SNP	C	TCGA-06-0237-01A-02D-1491-08		114257073	128942300	6	3064											
FANCD2	2177	broad.mit.edu	37	chr3	10084272	10084272	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggtgatggataagttgtcGtctattagattggaggattt	13	2	1	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr3:10084272G>A	uc003buw.2	+	11	891	c.813G>A	c.(811-813)TCG>TCA	p.S271S	FANCD2_uc003bux.1_Silent_p.S271S|FANCD2_uc003buy.1_Silent_p.S271S	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	271	Interaction with FANCE.|Interaction with BRCA2.				DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		ATAAGTTGTCGTCTATTAGAT	0.373			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				A	10084272	A	A	10084272	2	1	48	1	0	0	0	0	0	0	0	1	5665	1132	40	1		1	FANCD2	3	10084272	Silent	SNP	G	TCGA-06-0237-01A-02D-1491-08		10084272	187938158	7	3065											
PLS1	5357	broad.mit.edu	37	chr3	142405148	142405148	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcgagagcctattttcatcTgcttaatcagattgccccta	6	12	3	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr3:142405148T>G	uc010huv.2	+	9	1070	c.911T>G	c.(910-912)CTG>CGG	p.L304R	PLS1_uc003euz.2_Missense_Mutation_p.L304R|PLS1_uc003eva.2_Missense_Mutation_p.L304R	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	304	Actin-binding 1.|CH 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						TATTTTCATCTGCTTAATCAG	0.348													G	142405148	G	G	142405148	3	3	48	1	0	0	0	0	1	0	0	0	12107	1580	55	5	941	5	PLS1	3	142405148	Missense_Mutation	SNP	T	TCGA-06-0237-01A-02D-1491-08	132320876	142405148	55617282	8	3066											
CRYGS	1427	broad.mit.edu	37	chr3	186256595	186256595	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgcctgccacggtagttggGtagctcatagaaaatccaga	11	10	1	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr3:186256595G>T	uc003fqe.2	-	3	479	c.427C>A	c.(427-429)CCC>ACC	p.P143T	CRYGS_uc003fqf.2_Missense_Mutation_p.P143T	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	143	Beta/gamma crystallin 'Greek key' 4.						structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		CGGTAGTTGGGTAGCTCATAG	0.547													T	186256595	T	T	186256595	3	4	48	1	0	0	0	0	1	0	0	0	3919	1261	44	5	113	5	CRYGS	3	186256595	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	43851447	186256595	11765835	9	3067											
CCDC158	339965	broad.mit.edu	37	chr4	77252544	77252544	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttcagtggagtccctcaaCgagttgttgcttctgttggt	11	10	3	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr4:77252544C>T	uc003hkb.3	-	20	3036	c.2883G>A	c.(2881-2883)TCG>TCA	p.S961S		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	961	Ser-rich.									skin(3)|ovary(2)|pancreas(1)	6						AGTCCCTCAACGAGTTGTTGC	0.363													T	77252544	T	T	77252544	2	4	48	1	0	0	0	0	0	0	0	1	2790	523	19	1		1	CCDC158	4	77252544	Silent	SNP	C	TCGA-06-0237-01A-02D-1491-08		77252544	113901732	10	3068											
HPSE	10855	broad.mit.edu	37	chr4	84223361	84223361	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttctctttgaaccttgcaCgcttgccattaacaccttgg	6	14	1	1	rs138550346		TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr4:84223361C>T	uc003hoj.3	-	10	1366	c.1267G>A	c.(1267-1269)GTG>ATG	p.V423M	HPSE_uc010ika.2_Missense_Mutation_p.V365M|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.V166M|HPSE_uc011cct.1_Missense_Mutation_p.V349M|HPSE_uc003hok.3_Missense_Mutation_p.V423M	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	423					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	GAACCTTGCACGCTTGCCATT	0.408													T	84223361	T	T	84223361	3	4	48	1	0	0	0	0	1	0	0	0	7344	536	19	1	376	1	HPSE	4	84223361	Missense_Mutation	SNP	C	TCGA-06-0237-01A-02D-1491-08	6970817	84223361	106930915	11	3069											
ASB5	140458	broad.mit.edu	37	chr4	177136841	177136841	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttcctatgtagcttcggatAcagagtcggcaaagttggta	11	7	0	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr4:177136841A>G	uc003iuq.1	-	7	916	c.900T>C	c.(898-900)TGT>TGC	p.C300C	ASB5_uc003iup.1_Silent_p.C247C	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	300	SOCS box.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		AGCTTCGGATACAGAGTCGGC	0.363													G	177136841	G	G	177136841	2	3	48	1	0	0	0	0	0	0	0	1	1026	389	14	4		4	ASB5	4	177136841	Silent	SNP	A	TCGA-06-0237-01A-02D-1491-08	92913480	177136841	14017435	12	3070											
PLEKHG4B	153478	broad.mit.edu	37	chr5	182428	182428	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgctgctgagccgcacacGccaggcctgatgactgtcag	13	13	1	3	rs111247576	byFrequency	TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr5:182428G>A	uc003jak.2	+	18	3856	c.3806G>A	c.(3805-3807)CGC>CAC	p.R1269H		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1269					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGCCGCACACGCCAGGCCTGA	0.632													A	182428	A	A	182428	3	1	48	1	0	0	0	0	1	0	0	0	12072	1087	38	1	3876	1	PLEKHG4B	5	182428	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08		182428	180732832	13	3071											
IL31RA	133396	broad.mit.edu	37	chr5	55204208	55204208	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	atcatctgcaactacaccatCttttaccaagctgaaggtgg	7	11	3	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr5:55204208C>A	uc003jql.2	+	11	1535	c.1470C>A	c.(1468-1470)ATC>ATA	p.I490I	IL31RA_uc003jqk.2_Silent_p.I490I|IL31RA_uc011cqj.1_Silent_p.I348I|IL31RA_uc003jqm.2_Silent_p.I458I|IL31RA_uc003jqn.2_Silent_p.I490I|IL31RA_uc010iwa.1_Silent_p.I458I|IL31RA_uc003jqo.2_Silent_p.I348I	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	458	Extracellular (Potential).|Fibronectin type-III 5.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				ACTACACCATCTTTTACCAAG	0.443													A	55204208	A	A	55204208	2	1	48	1	0	0	0	0	0	0	0	1	7691	903	32	5		5	IL31RA	5	55204208	Silent	SNP	C	TCGA-06-0237-01A-02D-1491-08	55021780	55204208	125711052	14	3072											
HSD17B4	3295	broad.mit.edu	37	chr5	118810095	118810095	+	Splice_Site	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acaaattttcctttccctcaGattcagtggaagaaggagag	9	8	2	3			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr5:118810095G>C	uc003ksj.2	+	4	344	c.221_splice	c.e4-1	p.D74_splice	HSD17B4_uc011cwg.1_Splice_Site_p.D50_splice|HSD17B4_uc011cwh.1_Splice_Site_p.D56_splice|HSD17B4_uc011cwi.1_Splice_Site_p.D99_splice|HSD17B4_uc003ksk.3_Splice_Site|HSD17B4_uc011cwj.1_5'Flank|HSD17B4_uc010jcn.1_5'Flank	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4						bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	CTTTCCCTCAGATTCAGTGGA	0.428													C	118810095	C	C	118810095	5	2	48	1	0	0	0	0	0	0	1	0	7386	956	33	5	234	5	HSD17B4	5	118810095	Splice_Site	SNP	G	TCGA-06-0237-01A-02D-1491-08	63605887	118810095	62105165	15	3073											
ADAMTS19	171019	broad.mit.edu	37	chr5	128796140	128796140	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgctgctgcctcctttAccagctggggttcctgtcga	11	14	0	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr5:128796140A>C	uc003kvb.1	+	1	38	c.38A>C	c.(37-39)TAC>TCC	p.Y13S	ADAMTS19_uc003kvc.1_5'Flank	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	13					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TGCCTCCTTTACCAGCTGGGG	0.622													C	128796140	C	C	128796140	3	2	48	1	0	0	0	0	1	0	0	0	264	391	14	5	40	5	ADAMTS19	5	128796140	Missense_Mutation	SNP	A	TCGA-06-0237-01A-02D-1491-08	9986045	128796140	52119120	16	3074											
PCDHA10	56139	broad.mit.edu	37	chr5	140237348	140237348	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcgtctcccgctggcagcgCgggcggtgcagtcagtgagc	18	13	2	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr5:140237348C>T	uc003lhx.2	+	1	1715	c.1715C>T	c.(1714-1716)GCG>GTG	p.A572V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Missense_Mutation_p.A572V	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	572	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGCAGCGCGGGCGGTGCA	0.682													T	140237348	T	T	140237348	3	4	48	1	0	0	0	0	1	0	0	0	11520	768	27	1	1717	1	PCDHA10	5	140237348	Missense_Mutation	SNP	C	TCGA-06-0237-01A-02D-1491-08	11441208	140237348	40677912	17	3075											
PCDHAC1	56135	broad.mit.edu	37	chr5	140307832	140307832	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctcaaccccagcaggaacTtttcgttgctgaaaacaatg	7	12	1	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr5:140307832T>C	uc003lih.2	+	1	1531	c.1355T>C	c.(1354-1356)CTT>CCT	p.L452P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.L452P	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	452	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCAGGAACTTTTCGTTGCT	0.527													C	140307832	C	C	140307832	3	2	48	1	0	0	0	0	1	0	0	0	11532	1609	56	4	1357	4	PCDHAC1	5	140307832	Missense_Mutation	SNP	T	TCGA-06-0237-01A-02D-1491-08	70484	140307832	40607428	18	3076											
KIF4B	285643	broad.mit.edu	37	chr5	154395374	154395374	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagcgggtacagttaatgcGtcaaatgaaagaggatgctg	13	7	1	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr5:154395374G>A	uc010jih.1	+	1	2115	c.1955G>A	c.(1954-1956)CGT>CAT	p.R652H		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	652	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAGTTAATGCGTCAAATGAAA	0.408													A	154395374	A	A	154395374	3	1	48	1	0	0	0	0	1	0	0	0	8304	1145	40	1	1957	1	KIF4B	5	154395374	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	14087542	154395374	26519886	19	3077											
TRIM52	84851	broad.mit.edu	37	chr5	180687305	180687305	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggggcaaggaaggaggcggGtggatgtcaggatacagctc	19	6	1	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr5:180687305G>A	uc003mnp.2	-	1	815	c.510C>T	c.(508-510)CAC>CAT	p.H170H	uc003mnq.2_5'Flank	NM_032765	NP_116154	Q96A61	TRI52_HUMAN	tripartite motif-containing 52	170						intracellular	zinc ion binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.0106)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0588)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.232)		AAGGAGGCGGGTGGATGTCAG	0.537													A	180687305	A	A	180687305	2	1	48	1	0	0	0	0	0	0	0	1	16524	1252	44	3		3	TRIM52	5	180687305	Silent	SNP	G	TCGA-06-0237-01A-02D-1491-08	26291931	180687305	227955	20	3078											
DNAH8	1769	broad.mit.edu	37	chr6	38885721	38885721	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ttgatgagtgcaacaggattCctgtggagccttcagcagtt	12	8	1	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr6:38885721C>A	uc003ooe.1	+	68	10278	c.9678C>A	c.(9676-9678)TTC>TTA	p.F3226L	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAACAGGATTCCTGTGGAGCC	0.333													A	38885721	A	A	38885721	3	1	48	1	0	0	0	0	1	0	0	0	4607	854	30	5	9940	5	DNAH8	6	38885721	Missense_Mutation	SNP	C	TCGA-06-0237-01A-02D-1491-08		38885721	132229346	21	3079											
RSPO3	84870	broad.mit.edu	37	chr6	127469869	127469869	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aatggatgtttgtcatgtaaGcccagactattttttgctct	8	7	2	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr6:127469869G>C	uc003qar.2	+	2	464	c.174G>C	c.(172-174)AAG>AAC	p.K58N	RSPO3_uc003qas.1_Missense_Mutation_p.K58N	NM_032784	NP_116173	Q9BXY4	RSPO3_HUMAN	R-spondin 3 precursor	58	FU 1.					extracellular region	heparin binding				0				GBM - Glioblastoma multiforme(226;0.0555)		TGTCATGTAAGCCCAGACTAT	0.423													C	127469869	C	C	127469869	3	2	48	1	0	0	0	0	1	0	0	0	13711	962	34	5	180	5	RSPO3	6	127469869	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	88584148	127469869	43645198	22	3080											
QKI	9444	broad.mit.edu	37	chr6	163984752	163984755	+	Splice_Site	DEL	GTAA	-	-													tgaacctagtggtgtattagGtaagttcttctccccatggg							TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr6:163984752_163984755delGTAA	uc003qui.2	+	6	1485	c.934_splice	c.e6+1	p.G312_splice	QKI_uc003que.2_Frame_Shift_Del_p.G312fs|QKI_uc003quf.2_Splice_Site_p.E312_splice|QKI_uc003qug.2_Splice_Site_p.G312_splice|QKI_uc003quh.2_Splice_Site_p.E304_splice|QKI_uc003quj.2_Splice_Site_p.G304_splice	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform						mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		GGTGTATTAGGTAAGTTCTTCTCC	0.387													-	163984755	-	-	163984752	8	5	48	1	0	1	0	1	0	0	1	0	12873	1275	44	0	957	0	QKI	6	163984752	Splice_Site	DEL	GTAA	TCGA-06-0237-01A-02D-1491-08	36514883	163984752	7130315	23	3081											
DNAH11	8701	broad.mit.edu	37	chr7	21639469	21639469	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatttatgtagaattcaTtgacgacattgtggtggaag	11	3	1	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr7:21639469T>C	uc003svc.2	+	15	2763	c.2732T>C	c.(2731-2733)ATT>ACT	p.I911T		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	911	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTAGAATTCATTGACGACATT	0.373									Kartagener_syndrome				C	21639469	C	C	21639469	3	2	48	1	0	0	0	0	1	0	0	0	4599	1493	52	4	2790	4	DNAH11	7	21639469	Missense_Mutation	SNP	T	TCGA-06-0237-01A-02D-1491-08		21639469	137499194	24	3082											
EGFR	1956	broad.mit.edu	37	chr7	55210075	55210075	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caataactgtgaggtggtccTtgggaatttggaaattacct	11	6	0	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr7:55210075T>G	uc003tqk.2	+	2	431	c.185T>G	c.(184-186)CTT>CGT	p.L62R	EGFR_uc003tqh.2_Missense_Mutation_p.L62R|EGFR_uc003tqi.2_Missense_Mutation_p.L62R|EGFR_uc003tqj.2_Missense_Mutation_p.L62R|EGFR_uc010kzg.1_Missense_Mutation_p.L62R|EGFR_uc011kco.1_Missense_Mutation_p.L9R	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	62	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.L62R(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAGGTGGTCCTTGGGAATTTG	0.408		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			G	55210075	G	G	55210075	3	3	48	1	0	0	0	0	1	0	0	0	4967	1609	56	5	191	5	EGFR	7	55210075	Missense_Mutation	SNP	T	TCGA-06-0237-01A-02D-1491-08	33570606	55210075	103928588	25	3083											
JHDM1D	80853	broad.mit.edu	37	chr7	139790907	139790907	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctctgtcacacaaagaaaCgtgcatggccatttctgttc	8	11	3	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr7:139790907C>T	uc003vvm.2	-	20	2817	c.2813G>A	c.(2812-2814)CGT>CAT	p.R938H	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	938					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					CACAAAGAAACGTGCATGGCC	0.502													T	139790907	T	T	139790907	3	4	48	1	0	0	0	0	1	0	0	0	7948	536	19	1	16	1	JHDM1D	7	139790907	Missense_Mutation	SNP	C	TCGA-06-0237-01A-02D-1491-08	84580832	139790907	19347756	26	3084											
MLL3	58508	broad.mit.edu	37	chr7	151849845	151849845	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcagccggtaagagctcacTaatctgggagggtttgcaga	13	8	3	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr7:151849845T>C	uc003wla.2	-	49	12690	c.12471A>G	c.(12469-12471)TTA>TTG	p.L4157L	MLL3_uc003wkz.2_Silent_p.L3275L|MLL3_uc003wkx.2_Silent_p.L315L|MLL3_uc003wky.2_Silent_p.L1721L	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4157					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AAGAGCTCACTAATCTGGGAG	0.498			N		medulloblastoma								C	151849845	C	C	151849845	2	2	48	1	0	0	0	0	0	0	0	1	9622	1519	53	4		4	MLL3	7	151849845	Silent	SNP	T	TCGA-06-0237-01A-02D-1491-08	12058938	151849845	7288818	27	3085											
RP1L1	94137	broad.mit.edu	37	chr8	10469370	10469370	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagactccagaaacaaaatcCgagtggactgcaggggtgac	13	9	0	3			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr8:10469370C>T	uc003wtc.2	-	4	2467	c.2238G>A	c.(2236-2238)TCG>TCA	p.S746S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	746					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AAACAAAATCCGAGTGGACTG	0.652													T	10469370	T	T	10469370	2	4	48	1	0	0	0	0	0	0	0	1	13533	639	23	2		2	RP1L1	8	10469370	Silent	SNP	C	TCGA-06-0237-01A-02D-1491-08		10469370	135894652	28	3086											
NOV	4856	broad.mit.edu	37	chr8	120435276	120435276	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atagtcaagaagccagtgatGgtcattgggacctgcacctg	12	9	2	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr8:120435276G>T	uc003yoq.2	+	5	1199	c.978G>T	c.(976-978)ATG>ATT	p.M326I		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	326	CTCK.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGCCAGTGATGGTCATTGGGA	0.537													T	120435276	T	T	120435276	3	4	48	1	0	0	0	0	1	0	0	0	10553	1348	47	5	996	5	NOV	8	120435276	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	109965906	120435276	25928746	29	3087											
RAG1	5896	broad.mit.edu	37	chr11	36596275	36596275	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgtttgcttggccatccGtgtcaacaccttcctcagct	8	14	2	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr11:36596275G>A	uc001mwu.3	+	2	1545	c.1421G>A	c.(1420-1422)CGT>CAT	p.R474H	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	474			R -> H (in OS/T(-)B(-)NK(+) SCID; atypical).		histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TTGGCCATCCGTGTCAACACC	0.557									Familial_Hemophagocytic_Lymphohistiocytosis				A	36596275	A	A	36596275	3	1	48	1	0	0	0	0	1	0	0	0	13003	1145	40	1	1423	1	RAG1	11	36596275	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08		36596275	98410241	30	3088											
GAB2	9846	broad.mit.edu	37	chr11	77937662	77937662	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttggcttgggggggcggggTgggggagctatggctgagtc	23	6	0	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr11:77937662T>G	uc001ozh.2	-	4	1056	c.1056A>C	c.(1054-1056)CCA>CCC	p.P352P	GAB2_uc001ozg.2_Silent_p.P314P	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	352	SH3-binding.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			GGGGGCGGGGTGGGGGAGCTA	0.582													G	77937662	G	G	77937662	2	3	48	1	0	0	0	0	0	0	0	1	6149	1683	59	5		5	GAB2	11	77937662	Silent	SNP	T	TCGA-06-0237-01A-02D-1491-08	41341387	77937662	57068854	31	3089											
KCNJ5	3762	broad.mit.edu	37	chr11	128781583	128781583	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctcagtggcttcgtgtccGctttcctgttctccattgag	9	13	2	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr11:128781583G>A	uc001qet.2	+	2	729	c.415G>A	c.(415-417)GCT>ACT	p.A139T	KCNJ5_uc009zck.2_Missense_Mutation_p.A139T|KCNJ5_uc001qew.2_Missense_Mutation_p.A139T	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	139					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CTTCGTGTCCGCTTTCCTGTT	0.507													A	128781583	A	A	128781583	3	1	48	1	0	0	0	0	1	0	0	0	8054	1087	38	1	417	1	KCNJ5	11	128781583	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	50843921	128781583	6224933	32	3090											
NBEA	26960	broad.mit.edu	37	chr13	36202290	36202290	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatttggctataagcagcgaGgaccagaagcagttcgtgct	12	8	0	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr13:36202290G>A	uc001uvb.2	+	49	7728	c.7522G>A	c.(7522-7524)GGA>AGA	p.G2508R	NBEA_uc010abi.2_Missense_Mutation_p.G1164R|NBEA_uc010tee.1_Missense_Mutation_p.G301R|NBEA_uc010tef.1_Missense_Mutation_p.G301R|NBEA_uc010teg.1_Missense_Mutation_p.G301R|NBEA_uc001uvd.2_Missense_Mutation_p.G65R	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2508	BEACH.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TAAGCAGCGAGGACCAGAAGC	0.438													A	36202290	A	A	36202290	3	1	48	1	0	0	0	0	1	0	0	0	10187	1001	35	3	7716	3	NBEA	13	36202290	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08		36202290	78967588	33	3091											
INF2	64423	broad.mit.edu	37	chr14	105174270	105174271	+	Frame_Shift_Ins	INS	-	G	G													atgggtccccagccatcggcINSgggtgaacccacccacactg							TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr14:105174270_105174271insG	uc001ypb.2	+	8	1809_1810	c.1666_1667insG	c.(1666-1668)CGGfs	p.R556fs	INF2_uc010tyi.1_Frame_Shift_Ins_p.R556fs|INF2_uc001ypc.2_Frame_Shift_Ins_p.R556fs|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	556	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CAGCCATCGGCGGGTGAACCCA	0.663													G	105174271	G	G	105174270	7	5	48	1	0	1	1	0	0	0	0	0	7734	759	27	0	1696	0	INF2	14	105174270	Frame_Shift_Ins	INS	-	TCGA-06-0237-01A-02D-1491-08		105174270	2175270	34	3092											
ZWILCH	55055	broad.mit.edu	37	chr15	66806421	66806421	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtattcatagtggaaaaagtGgtaagtactggtttgacttt	11	3	1	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr15:66806421G>A	uc002aqb.2	+	3	447	c.201G>A	c.(199-201)GTG>GTA	p.V67V	RPL4_uc002apx.2_Intron|ZWILCH_uc010bhu.1_Intron|ZWILCH_uc002aqa.2_5'UTR|ZWILCH_uc010bhv.2_5'UTR	NM_017975	NP_060445	Q9H900	ZWILC_HUMAN	Zwilch	67					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			ovary(1)	1						TGGAAAAAGTGGTAAGTACTG	0.358													A	66806421	A	A	66806421	2	1	48	1	0	0	0	0	0	0	0	1	18245	1362	47	3		3	ZWILCH	15	66806421	Silent	SNP	G	TCGA-06-0237-01A-02D-1491-08		66806421	35724971	35	3093											
YPEL3	83719	broad.mit.edu	37	chr16	30106203	30106203	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acccgctcctcggctggcccGcagcccacgttcaccctgtg	10	20	1	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr16:30106203G>A	uc002dwm.2	-	4	363	c.177C>T	c.(175-177)TGC>TGT	p.C59C	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TBX6_uc010veh.1_5'Flank|TBX6_uc002dwk.1_5'Flank|YPEL3_uc002dwl.2_Silent_p.C97C|YPEL3_uc002dwn.1_Silent_p.C97C|uc002dwo.1_5'Flank	NM_001145524	NP_001138996	P61236	YPEL3_HUMAN	yippee-like 3 isoform 2	59						nucleolus					0						CGGCTGGCCCGCAGCCCACGT	0.632													A	30106203	A	A	30106203	2	1	48	1	0	0	0	0	0	0	0	1	17488	1079	38	1		1	YPEL3	16	30106203	Silent	SNP	G	TCGA-06-0237-01A-02D-1491-08		30106203	60248550	36	3094											
GPR114	221188	broad.mit.edu	37	chr16	57597817	57597817	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttccccgccgagctgaccCgggacgcctgcaagacccgc	12	18	0	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr16:57597817C>T	uc002elx.3	+	5	440	c.355C>T	c.(355-357)CGG>TGG	p.R119W	GPR114_uc010vhr.1_Missense_Mutation_p.R119W|GPR114_uc002ely.2_Missense_Mutation_p.R119W	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	119	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						CGAGCTGACCCGGGACGCCTG	0.632													T	57597817	T	T	57597817	3	4	48	1	0	0	0	0	1	0	0	0	6631	643	23	2	369	2	GPR114	16	57597817	Missense_Mutation	SNP	C	TCGA-06-0237-01A-02D-1491-08	27491614	57597817	32756936	37	3095											
TP53	7157	broad.mit.edu	37	chr17	7578265	7578265	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcaaatttccttccactcggAtaagatgctgaggaggggcc	12	10	0	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr17:7578265A>G	uc002gim.2	-	6	778	c.584T>C	c.(583-585)ATC>ACC	p.I195T	TP53_uc002gig.1_Missense_Mutation_p.I195T|TP53_uc002gih.2_Missense_Mutation_p.I195T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.I63T|TP53_uc010cng.1_Missense_Mutation_p.I63T|TP53_uc002gii.1_Missense_Mutation_p.I63T|TP53_uc010cnh.1_Missense_Mutation_p.I195T|TP53_uc010cni.1_Missense_Mutation_p.I195T|TP53_uc002gij.2_Missense_Mutation_p.I195T|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.I102T|TP53_uc002gio.2_Missense_Mutation_p.I63T|TP53_uc010vug.1_Missense_Mutation_p.I156T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	195	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> F (in sporadic cancers; somatic mutation).|I -> L (in a sporadic cancer; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> T (in sporadic cancers; somatic mutation).|I -> V (in a sporadic cancer; somatic mutation).|I -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|I -> N (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I195T(61)|p.I195F(16)|p.I195N(12)|p.0?(7)|p.I195S(4)|p.A189_V197delAPPQHLIRV(4)|p.I195fs*14(3)|p.I195fs*52(3)|p.K164_P219del(1)|p.I195L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.I195fs*12(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCCACTCGGATAAGATGCTG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			G	7578265	G	G	7578265	3	3	48	1	0	0	0	0	1	0	0	0	16378	333	12	4	710	4	TP53	17	7578265	Missense_Mutation	SNP	A	TCGA-06-0237-01A-02D-1491-08		7578265	73616945	38	3096											
LIG3	3980	broad.mit.edu	37	chr17	33323604	33323604	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccttacagaaagcagccttCcaggatgctaatgtctgcct	8	13	1	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr17:33323604C>T	uc002hik.1	+	11	1863	c.1755C>T	c.(1753-1755)TTC>TTT	p.F585F	LIG3_uc002hij.2_Silent_p.F585F	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	585					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	AAGCAGCCTTCCAGGATGCTA	0.428								Other_BER_factors					T	33323604	T	T	33323604	2	4	48	1	0	0	0	0	0	0	0	1	8782	854	30	3		3	LIG3	17	33323604	Silent	SNP	C	TCGA-06-0237-01A-02D-1491-08	25745339	33323604	47871606	39	3097											
XYLT2	64132	broad.mit.edu	37	chr17	48437602	48437602	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gctggagctctctgtcccccGaccccaaatcagagctgggg	12	15	2	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr17:48437602G>A	uc002iqo.2	+	11	2657	c.2548G>A	c.(2548-2550)GAC>AAC	p.D850N	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	850	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					TCTGTCCCCCGACCCCAAATC	0.647													A	48437602	A	A	48437602	3	1	48	1	0	0	0	0	1	0	0	0	17461	1058	37	2	2590	2	XYLT2	17	48437602	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	15113998	48437602	32757608	40	3098											
NOL11	25926	broad.mit.edu	37	chr17	65733682	65733682	+	Frame_Shift_Del	DEL	C	-	-													atttttggctctgaagcagaCacctgactttcatactgtca							TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr17:65733682delC	uc002jgd.1	+	12	1280	c.1277delC	c.(1276-1278)ACAfs	p.T426fs	NOL11_uc010wql.1_Frame_Shift_Del_p.T244fs|NOL11_uc010deu.1_Frame_Shift_Del_p.T21fs	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	426						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			CTGAAGCAGACACCTGACTTT	0.408													-	65733682	-	-	65733682	7	5	48	1	0	1	0	1	0	0	0	0	10521	478	17	0	1323	0	NOL11	17	65733682	Frame_Shift_Del	DEL	C	TCGA-06-0237-01A-02D-1491-08	17296080	65733682	15461528	41	3099											
CTAGE1	64693	broad.mit.edu	37	chr18	19997860	19997860	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttagccctaggctcctccGtagcgccaaggctgctctgg	13	14	1	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr18:19997860G>A	uc002ktv.1	-	1	19	c.-85C>T	c.(-87--83)TACGG>TATGG			NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1							integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGGCTCCTCCGTAGCGCCAAG	0.587													A	19997860	A	A	19997860	1	1	48	1	0	0	0	0	0	0	0	0	3992	1160	40	1		1	CTAGE1	18	19997860	Translation_Start_Site	SNP	G	TCGA-06-0237-01A-02D-1491-08		19997860	58079388	42	3100											
DCC	1630	broad.mit.edu	37	chr18	50734089	50734089	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atcttataaactggaaggccTgaaaaaattcaccgaatata	6	7	2	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr18:50734089T>C	uc002lfe.1	+	11	2350	c.1763T>C	c.(1762-1764)CTG>CCG	p.L588P	DCC_uc010xdr.1_Missense_Mutation_p.L436P|DCC_uc010dpf.1_Missense_Mutation_p.L243P	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	588	Extracellular (Potential).|Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTGGAAGGCCTGAAAAAATTC	0.383													C	50734089	C	C	50734089	3	2	48	1	0	0	0	0	1	0	0	0	4282	1580	55	4	1805	4	DCC	18	50734089	Missense_Mutation	SNP	T	TCGA-06-0237-01A-02D-1491-08	30736229	50734089	27343159	43	3101											
SALL3	27164	broad.mit.edu	37	chr18	76753975	76753975	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgatgcaaacgtcggaaaccTcgaagctgcagcagctggtg	13	11	0	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr18:76753975T>G	uc002lmt.2	+	2	1984	c.1984T>G	c.(1984-1986)TCG>GCG	p.S662A	SALL3_uc010dra.2_Missense_Mutation_p.S269A	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	662					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GTCGGAAACCTCGAAGCTGCA	0.637													G	76753975	G	G	76753975	3	3	48	1	0	0	0	0	1	0	0	0	13812	1551	54	5	1990	5	SALL3	18	76753975	Missense_Mutation	SNP	T	TCGA-06-0237-01A-02D-1491-08	26019886	76753975	1323273	44	3102											
CCDC94	55702	broad.mit.edu	37	chr19	4268683	4268683	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggacagtgacgacagcaacgGcagcaactgagccctcccag	12	14	0	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr19:4268683G>A	uc002lzv.3	+	8	995	c.962G>A	c.(961-963)GGC>GAC	p.G321D		NM_018074	NP_060544	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	321											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		GACAGCAACGGCAGCAACTGA	0.642													A	4268683	A	A	4268683	3	1	48	1	0	0	0	0	1	0	0	0	2873	1203	42	3	992	3	CCDC94	19	4268683	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08		4268683	54860300	45	3103											
CYP4F2	8529	broad.mit.edu	37	chr19	15989717	15989717	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggaccaccttcatctccGccatcgcgaacgtctgcccg	8	19	3	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr19:15989717G>A	uc002nbs.1	-	13	1477	c.1427C>T	c.(1426-1428)GCG>GTG	p.A476V	CYP4F2_uc010xot.1_Missense_Mutation_p.A327V	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	476					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CTTCATCTCCGCCATCGCGAA	0.672													A	15989717	A	A	15989717	3	1	48	1	0	0	0	0	1	0	0	0	4188	1087	38	1	139	1	CYP4F2	19	15989717	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	11721034	15989717	43139266	46	3104											
FFAR3	2865	broad.mit.edu	37	chr19	35850542	35850542	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcccatgtcgtgggctatatCtgcggtgaaagcccggcgtg	14	11	1	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr19:35850542C>T	uc002nzd.2	+	2	825	c.750C>T	c.(748-750)ATC>ATT	p.I250I	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	250	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			TGGGCTATATCTGCGGTGAAA	0.612													T	35850542	T	T	35850542	2	4	48	1	0	0	0	0	0	0	0	1	5829	903	32	3		3	FFAR3	19	35850542	Silent	SNP	C	TCGA-06-0237-01A-02D-1491-08	19860825	35850542	23278441	47	3105											
CYP2B6	1555	broad.mit.edu	37	chr19	41515926	41515926	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccaacgcacacagtgaattcAgccaccagaacctcaacctc	5	17	2	2			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr19:41515926A>T	uc002opr.1	+	6	857	c.850A>T	c.(850-852)AGC>TGC	p.S284C	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	284					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CAGTGAATTCAGCCACCAGAA	0.562													T	41515926	T	T	41515926	3	4	48	1	0	0	0	0	1	0	0	0	4164	188	7	5	872	5	CYP2B6	19	41515926	Missense_Mutation	SNP	A	TCGA-06-0237-01A-02D-1491-08	5665384	41515926	17613057	48	3106											
SLC17A9	63910	broad.mit.edu	37	chr20	61596986	61596986	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggccttggcctctccagcGtctttgctctgtgcctgggc	13	14	3	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr20:61596986G>A	uc002yea.3	+	10	1154	c.970G>A	c.(970-972)GTC>ATC	p.V324I	SLC17A9_uc002ydz.3_Missense_Mutation_p.V318I|SLC17A9_uc011aap.1_Missense_Mutation_p.V344I	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	324	Helical; (Potential).				exocytosis|transmembrane transport	integral to membrane	transporter activity	p.V324I(1)		ovary(1)|skin(1)	2						CCTCTCCAGCGTCTTTGCTCT	0.652													A	61596986	A	A	61596986	3	1	48	1	0	0	0	0	1	0	0	0	14424	1145	40	1	1008	1	SLC17A9	20	61596986	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08		61596986	1428534	49	3107											
EEF1A2	1917	broad.mit.edu	37	chr20	62122078	62122078	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccacccggcccacgggcacCgtgccaatgcctgcagaggg	13	17	0	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr20:62122078C>T	uc002yfd.1	-	5	884	c.783G>A	c.(781-783)ACG>ACA	p.T261T	EEF1A2_uc002yfe.1_Silent_p.T261T|EEF1A2_uc010gkg.1_Silent_p.T261T	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	261						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CCACGGGCACCGTGCCAATGC	0.647													T	62122078	T	T	62122078	2	4	48	1	0	0	0	0	0	0	0	1	4924	639	23	2		2	EEF1A2	20	62122078	Silent	SNP	C	TCGA-06-0237-01A-02D-1491-08	525092	62122078	903442	50	3108											
DSCR6	53820	broad.mit.edu	37	chr21	38380466	38380466	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccgttccagccccgcgccGtggcgaccttggatccagac	12	17	0	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr21:38380466G>A	uc002yvv.2	+	2	324	c.114G>A	c.(112-114)CCG>CCA	p.P38P	DSCR6_uc011aec.1_Translation_Start_Site|DSCR6_uc010gnd.2_Translation_Start_Site	NM_018962	NP_061835	P57055	DSCR6_HUMAN	Down syndrome critical region protein 6	38						nucleus				breast(1)	1		Myeloproliferative disorder(46;0.0632)				GCCCCGCGCCGTGGCGACCTT	0.577													A	38380466	A	A	38380466	2	1	48	1	0	0	0	0	0	0	0	1	4773	1132	40	1		1	DSCR6	21	38380466	Silent	SNP	G	TCGA-06-0237-01A-02D-1491-08		38380466	9749429	51	3109											
SIK1	150094	broad.mit.edu	37	chr21	44841555	44841555	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atgttgccatccagcaggagGttctcggtcttgaggtcccg	13	11	2	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chr21:44841555G>T	uc002zdf.2	-	5	589	c.462C>A	c.(460-462)AAC>AAA	p.N154K		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	154	Protein kinase.				anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						CCAGCAGGAGGTTCTCGGTCT	0.617													T	44841555	T	T	44841555	3	4	48	1	0	0	0	0	1	0	0	0	14317	1252	44	5	1929	5	SIK1	21	44841555	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	6461089	44841555	3288340	52	3110											
DCAF8L2	347442	broad.mit.edu	37	chrX	27766165	27766165	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atacctaccaatttgcagtgGgtggacaagatcagtttgta	10	7	1	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chrX:27766165G>T	uc011mjy.1	+	1	1240	c.1153G>T	c.(1153-1155)GGT>TGT	p.G385C		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						ATTTGCAGTGGGTGGACAAGA	0.398													T	27766165	T	T	27766165	3	4	48	1	0	0	0	0	1	0	0	0	4278	1232	43	5	1155	5	DCAF8L2	23	27766165	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08		27766165	127504395	53	3111											
SYTL5	94122	broad.mit.edu	37	chrX	37931389	37931389	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctcggcactgatgttgtccGacagtccattttaagaagaa	9	9	1	3	rs151098113	byFrequency	TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chrX:37931389G>A	uc004ddu.2	+	5	953	c.419G>A	c.(418-420)CGA>CAA	p.R140Q	SYTL5_uc004ddv.2_Missense_Mutation_p.R140Q|SYTL5_uc004ddx.2_Missense_Mutation_p.R140Q	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	140					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						GATGTTGTCCGACAGTCCATT	0.378													A	37931389	A	A	37931389	3	1	48	1	0	0	0	0	1	0	0	0	15483	1058	37	2	429	2	SYTL5	23	37931389	Missense_Mutation	SNP	G	TCGA-06-0237-01A-02D-1491-08	10165224	37931389	117339171	54	3112											
MAOA	4128	broad.mit.edu	37	chrX	43571152	43571152	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	catttcggggcgcctttccaCcagtatggaatcccattgca	9	13	0	0			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chrX:43571152C>A	uc004dfy.2	+	4	521	c.340C>A	c.(340-342)CCA>ACA	p.P114T	MAOA_uc011mkw.1_5'UTR	NM_000240	NP_000231	P21397	AOFA_HUMAN	monoamine oxidase A	114	Cytoplasmic.				behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			breast(2)|ovary(1)	3					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	CGCCTTTCCACCAGTATGGAA	0.368													A	43571152	A	A	43571152	3	1	48	1	0	0	0	0	1	0	0	0	9225	507	18	5	354	5	MAOA	23	43571152	Missense_Mutation	SNP	C	TCGA-06-0237-01A-02D-1491-08	5639763	43571152	111699408	55	3113											
SLC38A5	92745	broad.mit.edu	37	chrX	48317931	48317931	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaatgcttacctggatcttGggccaggataagaaaggctc	13	8	1	1			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chrX:48317931G>A	uc010nid.2	-	16	1486	c.1308C>T	c.(1306-1308)CCC>CCT	p.P436P	SLC38A5_uc004djk.3_Silent_p.P385P	NM_033518	NP_277053	Q8WUX1	S38A5_HUMAN	solute carrier family 38, member 5	436	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				ovary(3)	3						CCTGGATCTTGGGCCAGGATA	0.582													A	48317931	A	A	48317931	2	1	48	1	0	0	0	0	0	0	0	1	14607	1335	47	3		3	SLC38A5	23	48317931	Silent	SNP	G	TCGA-06-0237-01A-02D-1491-08	4746779	48317931	106952629	56	3114											
TGIF2LX	90316	broad.mit.edu	37	chrX	89177186	89177186	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caagacacctcaatcatgtcGagaaataacgcagatacagg	8	10	2	3			TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chrX:89177186G>A	uc004efe.2	+	2	151	c.102G>A	c.(100-102)TCG>TCA	p.S34S		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	34						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CAATCATGTCGAGAAATAACG	0.577													A	89177186	A	A	89177186	2	1	48	1	0	0	0	0	0	0	0	1	15824	1045	37	2		2	TGIF2LX	23	89177186	Silent	SNP	G	TCGA-06-0237-01A-02D-1491-08	40859255	89177186	66093374	57	3115											
MAMLD1	10046	broad.mit.edu	37	chrX	149639325	149639327	+	In_Frame_Del	DEL	CAG	-	-													gtaatcttctaagccagcaaCagcagcagcagcagcagcag							TCGA-06-0237-01A-02D-1491-08	TCGA-06-0237-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	a50b5271-484a-436e-ac6f-6074071015fd	604eef51-a3a7-405a-aff9-1db235384819	g.chrX:149639325_149639327delCAG	uc004fee.1	+	3	1556_1558	c.1480_1482delCAG	c.(1480-1482)CAGdel	p.Q502del	MAMLD1_uc011mxt.1_In_Frame_Del_p.Q464del|MAMLD1_uc011mxu.1_In_Frame_Del_p.Q477del|MAMLD1_uc011mxv.1_In_Frame_Del_p.Q477del|MAMLD1_uc011mxw.1_In_Frame_Del_p.Q429del	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	502	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCcagcaacagcagcagcagc	0.433													-	149639327	-	-	149639325	7	5	48	1	0	1	0	1	0	0	0	0	9208	479	17	0	1490	0	MAMLD1	23	149639325	In_Frame_Del	DEL	CAG	TCGA-06-0237-01A-02D-1491-08	60462139	149639325	5631235	58	3116											
ACAP3	116983	broad.mit.edu	37	chr1	1229020	1229020	+	Frame_Shift_Del	DEL	A	-	-													gctccgtggggctgcccgccAgggcgcccgggggaccaggg							TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr1:1229020delA	uc001aeb.2	-	24	2503	c.2429delT	c.(2428-2430)CTGfs	p.L810fs	ACAP3_uc001ady.2_Frame_Shift_Del_p.L540fs|ACAP3_uc001aea.2_Frame_Shift_Del_p.L735fs	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	810					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						GCTGCCCGCCAGGGCGCCCGG	0.721													-	1229020	-	-	1229020	7	5	49	1	0	1	0	1	0	0	0	0	120	188	7	0	79	0	ACAP3	1	1229020	Frame_Shift_Del	DEL	A	TCGA-06-0238-01A-02D-1492-08		1229020	248021601	1	3117											
KPRP	448834	broad.mit.edu	37	chr1	152732806	152732806	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagcttcactgaacagcacCgctctcggagcaccagcaga	11	14	2	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr1:152732806C>T	uc001fal.1	+	2	800	c.742C>T	c.(742-744)CGC>TGC	p.R248C		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	248						cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAACAGCACCGCTCTCGGAG	0.612													T	152732806	T	T	152732806	3	4	49	1	0	0	0	0	1	0	0	0	8436	652	23	2	744	2	KPRP	1	152732806	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	151503786	152732806	96517815	2	3118											
OR10Z1	128368	broad.mit.edu	37	chr1	158577000	158577000	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attatggctgtgcttccttcGtgtacctgaggcccaaagcc	10	12	0	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr1:158577000G>A	uc010pio.1	+	1	772	c.772G>A	c.(772-774)GTG>ATG	p.V258M		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	258	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TGCTTCCTTCGTGTACCTGAG	0.493													A	158577000	A	A	158577000	3	1	49	1	0	0	0	0	1	0	0	0	10923	1145	40	1	774	1	OR10Z1	1	158577000	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08	5844194	158577000	90673621	3	3119											
SPTA1	6708	broad.mit.edu	37	chr1	158650498	158650498	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctcccagtcttcacctagctCcactgatgtcgctatagcct	6	16	2	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr1:158650498C>G	uc001fst.1	-	5	752	c.553G>C	c.(553-555)GAG>CAG	p.E185Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	185	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCACCTAGCTCCACTGATGTC	0.448													G	158650498	G	G	158650498	3	3	49	1	0	0	0	0	1	0	0	0	15115	864	30	5	6898	5	SPTA1	1	158650498	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	73498	158650498	90600123	4	3120											
ZNF496	84838	broad.mit.edu	37	chr1	247464286	247464286	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacaccgagcactcgtgcggCttctcctgctccctgcggct	10	18	1	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr1:247464286C>T	uc001ico.2	-	9	1764	c.1299G>A	c.(1297-1299)AAG>AAA	p.K433K	ZNF496_uc009xgv.2_Silent_p.K469K|ZNF496_uc001icp.2_Silent_p.K433K	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	433					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			ACTCGTGCGGCTTCTCCTGCT	0.617													T	247464286	T	T	247464286	2	4	49	1	0	0	0	0	0	0	0	1	17942	796	28	3		3	ZNF496	1	247464286	Silent	SNP	C	TCGA-06-0238-01A-02D-1492-08	88813788	247464286	1786335	5	3121											
OR2T34	127068	broad.mit.edu	37	chr1	248737752	248737752	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtggaagaacatctggatccCacagcctgacggggaaatgg	14	9	1	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr1:248737752C>A	uc001iep.1	-	1	307	c.307G>T	c.(307-309)GGG>TGG	p.G103W		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	103	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATCTGGATCCCACAGCCTGAC	0.562													A	248737752	A	A	248737752	3	1	49	1	0	0	0	0	1	0	0	0	11025	594	21	5	653	5	OR2T34	1	248737752	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	1273466	248737752	512869	6	3122											
TEKT4	150483	broad.mit.edu	37	chr2	95537569	95537569	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacccaggcgctggcgcagcGcacgcagcaagactccacgc	13	17	0	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr2:95537569G>A	uc002stw.1	+	1	338	c.245G>A	c.(244-246)CGC>CAC	p.R82H	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	82					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						CTGGCGCAGCGCACGCAGCAA	0.692													A	95537569	A	A	95537569	3	1	49	1	0	0	0	0	1	0	0	0	15752	1087	38	1	247	1	TEKT4	2	95537569	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08		95537569	147661804	7	3123											
IWS1	55677	broad.mit.edu	37	chr2	128238721	128238721	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctcatctgtttatccagtcGactgatacccttcttggagg	8	11	3	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr2:128238721G>A	uc002ton.2	-	14	2662	c.2359C>T	c.(2359-2361)CGA>TGA	p.R787*		NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	787					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TTATCCAGTCGACTGATACCC	0.388													A	128238721	A	A	128238721	4	1	49	1	0	0	0	0	0	1	0	0	7931	1066	37	2	104	2	IWS1	2	128238721	Nonsense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08	32701152	128238721	114960652	8	3124											
PCDH7	5099	broad.mit.edu	37	chr4	30725870	30725870	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaggacaagaaaaacaaaaaAtctaagcagcctctctacag	6	9	2	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr4:30725870A>G	uc003gsk.1	+	1	3834	c.2826A>G	c.(2824-2826)AAA>AAG	p.K942K	PCDH7_uc011bxw.1_Silent_p.K895K|PCDH7_uc011bxx.1_Silent_p.K942K	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	942	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						AAAACAAAAAATCTAAGCAGC	0.413													G	30725870	G	G	30725870	2	3	49	1	0	0	0	0	0	0	0	1	11516	98	4	4		4	PCDH7	4	30725870	Silent	SNP	A	TCGA-06-0238-01A-02D-1492-08		30725870	160428406	9	3125											
PTCD2	79810	broad.mit.edu	37	chr5	71627105	71627105	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtaccatgcagagaacaaaaAtttcactttgggggagtata	10	6	1	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr5:71627105A>G	uc003kcb.2	+	4	381	c.371A>G	c.(370-372)AAT>AGT	p.N124S	PTCD2_uc011csf.1_5'UTR|PTCD2_uc003kcc.2_5'UTR|PTCD2_uc011csg.1_Intron|PTCD2_uc011csh.1_Intron|PTCD2_uc003kcd.2_RNA	NM_024754	NP_079030	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	124											0		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		GAGAACAAAAATTTCACTTTG	0.393													G	71627105	G	G	71627105	3	3	49	1	0	0	0	0	1	0	0	0	12728	101	4	4	385	4	PTCD2	5	71627105	Missense_Mutation	SNP	A	TCGA-06-0238-01A-02D-1492-08		71627105	109288155	10	3126											
SV2C	22987	broad.mit.edu	37	chr5	75428120	75428120	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttacccagtgctgagacagAcctctgcatcccaaattcag	8	13	2	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr5:75428120A>G	uc003kei.1	+	2	679	c.545A>G	c.(544-546)GAC>GGC	p.D182G		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	182	Extracellular (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		GCTGAGACAGACCTCTGCATC	0.502													G	75428120	G	G	75428120	3	3	49	1	0	0	0	0	1	0	0	0	15416	275	10	4	547	4	SV2C	5	75428120	Missense_Mutation	SNP	A	TCGA-06-0238-01A-02D-1492-08	3801015	75428120	105487140	11	3127											
UQCRQ	27089	broad.mit.edu	37	chr5	132202700	132202701	+	Frame_Shift_Ins	INS	-	G	G													caatgttctgcgccgcattcINSgggagtctttctttcgcgtg							TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr5:132202700_132202701insG	uc003kya.1	+	2	201_202	c.127_128insG	c.(127-129)CGGfs	p.R43fs	GDF9_uc003kxz.1_5'Flank|GDF9_uc011cxj.1_5'Flank	NM_014402	NP_055217	O14949	QCR8_HUMAN	ubiquinol-cytochrome c reductase, complex III	43					respiratory electron transport chain	mitochondrial inner membrane|respiratory chain	ubiquinol-cytochrome-c reductase activity				0		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCGCCGCATTCGGGAGTCTTTC	0.629													G	132202701	G	G	132202700	7	5	49	1	0	1	1	0	0	0	0	0	17021	875	31	0	129	0	UQCRQ	5	132202700	Frame_Shift_Ins	INS	-	TCGA-06-0238-01A-02D-1492-08	56774580	132202700	48712560	12	3128											
PCDHA1	56147	broad.mit.edu	37	chr5	140167621	140167621	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagtcagtgagctggtgccGcgattggtgggtgcgggtca	19	8	2	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr5:140167621G>A	uc003lhb.2	+	1	1746	c.1746G>A	c.(1744-1746)CCG>CCA	p.P582P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Silent_p.P582P	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	582	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTGGTGCCGCGATTGGTGG	0.657													A	140167621	A	A	140167621	2	1	49	1	0	0	0	0	0	0	0	1	11519	1074	38	1		1	PCDHA1	5	140167621	Silent	SNP	G	TCGA-06-0238-01A-02D-1492-08	7964921	140167621	40747639	13	3129											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720885	140720885	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cggacacgctcatcagccagGagagctgtgagaaaaaggat	13	9	2	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr5:140720885G>A	uc003ljk.1	+	1	2532	c.2347G>A	c.(2347-2349)GAG>AAG	p.E783K	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Missense_Mutation_p.E783K|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	783	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCAGCCAGGAGAGCTGTGA	0.488													A	140720885	A	A	140720885	3	1	49	1	0	0	0	0	1	0	0	0	11554	1175	41	3	2349	3	PCDHGA2	5	140720885	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08	553264	140720885	40194375	14	3130											
ODZ2	57451	broad.mit.edu	37	chr5	167627098	167627098	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	catctgggacaagacagatgCgtatggccaaagggtgtatg	14	7	1	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr5:167627098C>G	uc010jjd.2	+	17	3365	c.3365C>G	c.(3364-3366)GCG>GGG	p.A1122G	ODZ2_uc003lzr.3_Missense_Mutation_p.A899G|ODZ2_uc003lzt.3_Missense_Mutation_p.A495G|ODZ2_uc010jje.2_Missense_Mutation_p.A393G	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		AAGACAGATGCGTATGGCCAA	0.453													G	167627098	G	G	167627098	3	3	49	1	0	0	0	0	1	0	0	0	10835	768	27	5	3431	5	ODZ2	5	167627098	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	26906213	167627098	13288162	15	3131											
DAXX	1616	broad.mit.edu	37	chr6	33287338	33287338	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgattgcttcctggaagaggAaatgtccgtctccacagagg	12	9	1	3			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr6:33287338A>G	uc003oec.2	-	6	1963	c.1759T>C	c.(1759-1761)TCC>CCC	p.S587P	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Missense_Mutation_p.S512P|DAXX_uc011dre.1_Missense_Mutation_p.S599P|DAXX_uc003oed.2_Missense_Mutation_p.S587P	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	587	Interaction with MAP3K5.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						CTGGAAGAGGAAATGTCCGTC	0.527			Mis|F|N		Pancreatic neuroendocrine tumors								G	33287338	G	G	33287338	3	3	49	1	0	0	0	0	1	0	0	0	4243	246	9	4	475	4	DAXX	6	33287338	Missense_Mutation	SNP	A	TCGA-06-0238-01A-02D-1492-08		33287338	137827729	16	3132											
UBE2CBP	90025	broad.mit.edu	37	chr6	83728822	83728822	+	Frame_Shift_Del	DEL	C	-	-													tttggaatttctcaaagattCaatcaccaaactgtctgaat							TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr6:83728822delC	uc003pjp.2	-	8	988	c.880delG	c.(880-882)GAAfs	p.E294fs	UBE2CBP_uc011dyx.1_RNA|UBE2CBP_uc003pjq.2_Frame_Shift_Del_p.E84fs	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	294						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)		CTCAAAGATTCAATCACCAAA	0.353													-	83728822	-	-	83728822	7	5	49	1	0	1	0	1	0	0	0	0	16844	835	29	0	301	0	UBE2CBP	6	83728822	Frame_Shift_Del	DEL	C	TCGA-06-0238-01A-02D-1492-08	50441484	83728822	87386245	17	3133											
TFPI2	7980	broad.mit.edu	37	chr7	93516588	93516588	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actaccttttgcacatgcacGtttgcaatcctccctgctaa	5	14	0	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr7:93516588G>A	uc003umy.1	-	4	691	c.616C>T	c.(616-618)CGT>TGT	p.R206C	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_Silent_p.N180N|TFPI2_uc003una.1_Missense_Mutation_p.R195C|TFPI2_uc003unb.1_Missense_Mutation_p.R212C|TFPI2_uc010lfg.1_Missense_Mutation_p.R82C	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	206	BPTI/Kunitz inhibitor 3.				blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			GCACATGCACGTTTGCAATCC	0.323													A	93516588	A	A	93516588	3	1	49	1	0	0	0	0	1	0	0	0	15806	1145	40	1	99	1	TFPI2	7	93516588	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08		93516588	65622075	18	3134											
ASZ1	136991	broad.mit.edu	37	chr7	117024817	117024817	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttttgcaatctcacttggcAtctttccatctttggtttgt	6	9	3	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr7:117024817A>G	uc003vjb.2	-	6	713	c.650T>C	c.(649-651)ATG>ACG	p.M217T	ASZ1_uc011kno.1_Missense_Mutation_p.M217T|ASZ1_uc011knp.1_Missense_Mutation_p.M9T	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	217	ANK 6.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CTCACTTGGCATCTTTCCATC	0.353													G	117024817	G	G	117024817	3	3	49	1	0	0	0	0	1	0	0	0	1069	217	8	4	809	4	ASZ1	7	117024817	Missense_Mutation	SNP	A	TCGA-06-0238-01A-02D-1492-08	23508229	117024817	42113846	19	3135											
KEL	3792	broad.mit.edu	37	chr7	142658531	142658531	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggatagctgtcagcacccGcctggccactgcccatggcc	11	17	1	0	rs150577967		TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr7:142658531G>A	uc003wcb.2	-	3	349	c.139C>T	c.(139-141)CGG>TGG	p.R47W		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	47	Cytoplasmic (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GTCAGCACCCGCCTGGCCACT	0.547													A	142658531	A	A	142658531	3	1	49	1	0	0	0	0	1	0	0	0	8142	1086	38	1	2127	1	KEL	7	142658531	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08	25633714	142658531	16480132	20	3136											
MLL3	58508	broad.mit.edu	37	chr7	151927093	151927093	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgctccttggccaaaactgCcacaaactacacacatatcc	4	16	0	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr7:151927093C>A	uc003wla.2	-	18	3110	c.2891G>T	c.(2890-2892)GGC>GTC	p.G964V	MLL3_uc003wkz.2_Missense_Mutation_p.G25V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	964	PHD-type 4.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCCAAAACTGCCACAAACTAC	0.348			N		medulloblastoma								A	151927093	A	A	151927093	3	1	49	1	0	0	0	0	1	0	0	0	9622	739	26	5	12012	5	MLL3	7	151927093	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	9268562	151927093	7211570	21	3137											
TLE4	7091	broad.mit.edu	37	chr9	82324566	82324566	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatccacaccatcacatgcGtgtgccagcaatacctccaa	6	15	1	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr9:82324566G>A	uc004ald.2	+	15	2216	c.1367G>A	c.(1366-1368)CGT>CAT	p.R456H	TLE4_uc004alc.2_Missense_Mutation_p.R431H|TLE4_uc010mpr.2_Missense_Mutation_p.R310H|TLE4_uc004ale.2_Missense_Mutation_p.R68H|TLE4_uc011lsq.1_Missense_Mutation_p.R399H|TLE4_uc010mps.2_Missense_Mutation_p.R355H|TLE4_uc004alf.2_Missense_Mutation_p.R370H	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CATCACATGCGTGTGCCAGCA	0.438													A	82324566	A	A	82324566	3	1	49	1	0	0	0	0	1	0	0	0	15938	1145	40	1	1346	1	TLE4	9	82324566	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08		82324566	58888865	22	3138											
FLJ46321	389763	broad.mit.edu	37	chr9	84605747	84605747	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatgataccaaccactttcGtcgactgttatgcccagacc	6	14	1	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr9:84605747G>A	uc004amn.2	+	4	409	c.362G>A	c.(361-363)CGT>CAT	p.R121H		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	121						integral to membrane					0						AACCACTTTCGTCGACTGTTA	0.537													A	84605747	A	A	84605747	3	1	49	1	0	0	0	0	1	0	0	0	5932	1145	40	1	376	1	FLJ46321	9	84605747	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08	2281181	84605747	56607684	23	3139											
ZNF618	114991	broad.mit.edu	37	chr9	116779034	116779034	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acaagtactacactccctacCaggagcatgtggccttacac	7	14	0	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr9:116779034C>A	uc004bid.2	+	10	913	c.814C>A	c.(814-816)CAG>AAG	p.Q272K	ZNF618_uc004bib.1_Missense_Mutation_p.Q240K|ZNF618_uc004bic.2_Missense_Mutation_p.Q260K|ZNF618_uc011lxi.1_Missense_Mutation_p.Q240K|ZNF618_uc011lxj.1_Missense_Mutation_p.Q240K	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	272	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACTCCCTACCAGGAGCATGT	0.572													A	116779034	A	A	116779034	3	1	49	1	0	0	0	0	1	0	0	0	18039	595	21	5	816	5	ZNF618	9	116779034	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	32173287	116779034	24434397	24	3140											
OR5P2	120065	broad.mit.edu	37	chr11	7818165	7818165	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccatggcagccagaaggaCgcattcgactgttgcaaaga	13	10	0	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr11:7818165C>T	uc001mfp.1	-	1	325	c.325G>A	c.(325-327)GTC>ATC	p.V109I		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V109I(1)		ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCCAGAAGGACGCATTCGACT	0.483													T	7818165	T	T	7818165	3	4	49	1	0	0	0	0	1	0	0	0	11178	536	19	1	647	1	OR5P2	11	7818165	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08		7818165	127188351	25	3141											
TMEM41B	440026	broad.mit.edu	37	chr11	9305021	9305021	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaagatggctggcagaatagAaagaacagccaagatcatca	11	7	2	5			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr11:9305021A>G	uc001mhm.2	-	7	1134	c.826T>C	c.(826-828)TCT>CCT	p.S276P	TMEM41B_uc001mhn.1_Missense_Mutation_p.S276P	NM_015012	NP_055827	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B isoform 1	276	Helical; (Potential).					integral to membrane					0				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		GGCAGAATAGAAAGAACAGCC	0.358													G	9305021	G	G	9305021	3	3	49	1	0	0	0	0	1	0	0	0	16162	246	9	4	53	4	TMEM41B	11	9305021	Missense_Mutation	SNP	A	TCGA-06-0238-01A-02D-1492-08	1486856	9305021	125701495	26	3142											
CASP1	834	broad.mit.edu	37	chr11	104900443	104900443	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggtttgtccttcaaacttgGgcagttcttggtattcaaca	9	9	3	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr11:104900443G>A	uc010rve.1	-	6	828	c.811C>T	c.(811-813)CCA>TCA	p.P271S	CASP1_uc001pig.2_Missense_Mutation_p.P178S|CASP1_uc001pik.2_Missense_Mutation_p.P234S|CASP1_uc010rvf.1_Missense_Mutation_p.P178S|CASP1_uc010rvg.1_Missense_Mutation_p.P250S|CASP1_uc010rvh.1_Missense_Mutation_p.P178S|CASP1_uc010rvi.1_Intron|CASP1_uc001pim.3_Missense_Mutation_p.P271S|CASP1_uc009yxi.2_Missense_Mutation_p.P250S|CASP1_uc010rvj.1_Missense_Mutation_p.P271S|CASP1_uc009yxj.2_Missense_Mutation_p.P116S|CASP1_uc010rvk.1_Missense_Mutation_p.P232S	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	271					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TTCAAACTTGGGCAGTTCTTG	0.448													A	104900443	A	A	104900443	3	1	49	1	0	0	0	0	1	0	0	0	2668	1232	43	3	419	3	CASP1	11	104900443	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08	95595422	104900443	30106073	27	3143											
MARS	4141	broad.mit.edu	37	chr12	57910320	57910320	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	agaaacagttggctgtagctGaggggaaaccccctgaagcc	13	10	0	3			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr12:57910320G>A	uc001sog.2	+	21	2682	c.2659G>A	c.(2659-2661)GAG>AAG	p.E887K	MARS_uc001sof.1_RNA|MARS_uc001soh.1_3'UTR	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	887	WHEP-TRS.				methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	GGCTGTAGCTGAGGGGAAACC	0.433													A	57910320	A	A	57910320	3	1	49	1	0	0	0	0	1	0	0	0	9316	1291	45	3	2741	3	MARS	12	57910320	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08		57910320	75941575	28	3144											
DDIT3	1649	broad.mit.edu	37	chr12	57911096	57911096	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ataggtacccccattttcatCtgaagacaggacctcttgca	7	12	3	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr12:57911096C>A	uc001soi.2	-	3	274	c.94G>T	c.(94-96)GAT>TAT	p.D32Y	MARS_uc001sof.1_RNA|DDIT3_uc009zps.2_Missense_Mutation_p.D55Y|DDIT3_uc009zpt.2_Missense_Mutation_p.D55Y	NM_004083	NP_004074	P35638	DDIT3_HUMAN	DNA-damage-inducible transcript 3	32					cell cycle arrest|cell redox homeostasis|mRNA transcription from RNA polymerase II promoter|negative regulation of determination of dorsal identity|regulation of DNA-dependent transcription in response to stress|response to DNA damage stimulus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding	p.D32Y(1)	FUS/DDIT3(623)|EWSR1/DDIT3(43)	soft_tissue(666)|large_intestine(1)|central_nervous_system(1)|lung(1)|skin(1)|ovary(1)	671						CCATTTTCATCTGAAGACAGG	0.493			T	FUS	liposarcoma								A	57911096	A	A	57911096	3	1	49	1	0	0	0	0	1	0	0	0	4330	913	32	5	423	5	DDIT3	12	57911096	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	776	57911096	75940799	29	3145											
PIP4K2C	79837	broad.mit.edu	37	chr12	57994645	57994645	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gccttctgctaggcatccacGacatcattcggggctctgaa	10	13	3	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr12:57994645G>T	uc001sou.2	+	8	996	c.865G>T	c.(865-867)GAC>TAC	p.D289Y	PIP4K2C_uc001sot.2_Missense_Mutation_p.D289Y|PIP4K2C_uc010srs.1_Missense_Mutation_p.D271Y|PIP4K2C_uc010srt.1_Missense_Mutation_p.D241Y	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	289	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					AGGCATCCACGACATCATTCG	0.552													T	57994645	T	T	57994645	3	4	49	1	0	0	0	0	1	0	0	0	11938	1058	37	5	895	5	PIP4K2C	12	57994645	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08	83549	57994645	75857250	30	3146											
PIP4K2C	79837	broad.mit.edu	37	chr12	57994848	57994848	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ttcattgatgtctatgccatCcggagtgctgaaggtgagag	13	7	2	3			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr12:57994848C>G	uc001sou.2	+	8	1199	c.1068C>G	c.(1066-1068)ATC>ATG	p.I356M	PIP4K2C_uc001sot.2_Missense_Mutation_p.I356M|PIP4K2C_uc010srs.1_Missense_Mutation_p.I338M|PIP4K2C_uc010srt.1_Missense_Mutation_p.I308M	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	356	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					TCTATGCCATCCGGAGTGCTG	0.562													G	57994848	G	G	57994848	3	3	49	1	0	0	0	0	1	0	0	0	11938	845	30	5	1098	5	PIP4K2C	12	57994848	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	203	57994848	75857047	31	3147											
TSPAN31	6302	broad.mit.edu	37	chr12	58140433	58140433	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gactcgggatgaactggaaaGaagttttgattgttgtggct	14	4	0	3			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr12:58140433G>A	uc001spt.2	+	4	528	c.374G>A	c.(373-375)AGA>AAA	p.R125K	TSPAN31_uc009zqb.2_Intron|TSPAN31_uc010ssa.1_Missense_Mutation_p.R47K	NM_005981	NP_005972	Q12999	TSN31_HUMAN	sarcoma amplified sequence	125	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane|membrane fraction					0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			GAACTGGAAAGAAGTTTTGAT	0.448													A	58140433	A	A	58140433	3	1	49	1	0	0	0	0	1	0	0	0	16643	942	33	3	388	3	TSPAN31	12	58140433	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08	145585	58140433	75711462	32	3148											
TPTE2	93492	broad.mit.edu	37	chr13	20066995	20066995	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtatttataactcaccttttActgataggtgacaccagggc	8	9	1	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr13:20066995A>T	uc001umd.2	-	4	325	c.114T>A	c.(112-114)AGT>AGA	p.S38R	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.S38R|TPTE2_uc001ume.2_Missense_Mutation_p.S38R|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	38						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CTCACCTTTTACTGATAGGTG	0.388													T	20066995	T	T	20066995	3	4	49	1	0	0	0	0	1	0	0	0	16428	388	14	5	1526	5	TPTE2	13	20066995	Missense_Mutation	SNP	A	TCGA-06-0238-01A-02D-1492-08		20066995	95102883	33	3149											
PCNX	22990	broad.mit.edu	37	chr14	71495452	71495452	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgcagcactttacagttttAtctgtagcattgttgcagta	8	7	1	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr14:71495452A>C	uc001xmo.2	+	16	3948	c.3502A>C	c.(3502-3504)ATC>CTC	p.I1168L	PCNX_uc010are.1_Missense_Mutation_p.I1057L|PCNX_uc010arf.1_Missense_Mutation_p.I28L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1168	Helical; (Potential).					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TTACAGTTTTATCTGTAGCAT	0.308													C	71495452	C	C	71495452	3	2	49	1	0	0	0	0	1	0	0	0	11591	449	16	5	3564	5	PCNX	14	71495452	Missense_Mutation	SNP	A	TCGA-06-0238-01A-02D-1492-08		71495452	35854088	34	3150											
TJP1	7082	broad.mit.edu	37	chr15	30003151	30003151	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagtggcctggatgggttcaTagcgtttctcgccaaatgat	13	8	2	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr15:30003151T>C	uc001zcr.2	-	24	4731	c.4256A>G	c.(4255-4257)TAT>TGT	p.Y1419C	TJP1_uc010azl.2_Missense_Mutation_p.Y1407C|TJP1_uc001zcq.2_Missense_Mutation_p.Y1343C|TJP1_uc001zcs.2_Missense_Mutation_p.Y1339C	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1419					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GATGGGTTCATAGCGTTTCTC	0.512													C	30003151	C	C	30003151	3	2	49	1	0	0	0	0	1	0	0	0	15926	1406	49	4	1010	4	TJP1	15	30003151	Missense_Mutation	SNP	T	TCGA-06-0238-01A-02D-1492-08		30003151	72528241	35	3151											
ARNT2	9915	broad.mit.edu	37	chr15	80883952	80883952	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagttccaagggcggccctcGgaagtctggtcgcagtggca	15	12	1	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr15:80883952G>A	uc002bfr.2	+	18	2128	c.1962G>A	c.(1960-1962)TCG>TCA	p.S654S	ARNT2_uc010unm.1_Silent_p.S643S|ARNT2_uc002bfs.2_Silent_p.S643S	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	654					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GGCGGCCCTCGGAAGTCTGGT	0.567													A	80883952	A	A	80883952	2	1	49	1	0	0	0	0	0	0	0	1	966	1103	39	2		2	ARNT2	15	80883952	Silent	SNP	G	TCGA-06-0238-01A-02D-1492-08	50880801	80883952	21647440	36	3152											
RSL1D1	26156	broad.mit.edu	37	chr16	11931690	11931690	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttttgggccattttttggggGtgtgggaagcttttctcaca	13	6	1	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr16:11931690G>T	uc002dbp.1	-	9	1500	c.1427C>A	c.(1426-1428)ACC>AAC	p.T476N	RSL1D1_uc010buv.1_Missense_Mutation_p.T475N|RSL1D1_uc010uyw.1_Missense_Mutation_p.T256N	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	476					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						TTTTTTGGGGGTGTGGGAAGC	0.353													T	11931690	T	T	11931690	3	4	49	1	0	0	0	0	1	0	0	0	13700	1261	44	5	49	5	RSL1D1	16	11931690	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08		11931690	78423063	37	3153											
SMG1	23049	broad.mit.edu	37	chr16	18875133	18875133	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	taatttataacctcaggggaAgagtcagtcggtttggacag	12	6	2	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr16:18875133A>T	uc002dfm.2	-	25	3897	c.3534T>A	c.(3532-3534)TCT>TCA	p.S1178S	SMG1_uc010bwb.2_Silent_p.S1038S	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1178	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CCTCAGGGGAAGAGTCAGTCG	0.388													T	18875133	T	T	18875133	2	4	49	1	0	0	0	0	0	0	0	1	14795	59	3	5		5	SMG1	16	18875133	Silent	SNP	A	TCGA-06-0238-01A-02D-1492-08	6943443	18875133	71479620	38	3154											
TP53	7157	broad.mit.edu	37	chr17	7577558	7577566	+	In_Frame_Del	DEL	GGAACTGTT	-	-													cggttcatgccgcccatgcaGgaactgttacacatgtagtt					rs28934573		TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr17:7577558_7577566delGGAACTGTT	uc002gim.2	-	7	909_917	c.715_723delAACAGTTCC	c.(715-723)AACAGTTCCdel	p.NSS239del	TP53_uc002gig.1_In_Frame_Del_p.NSS239del|TP53_uc002gih.2_In_Frame_Del_p.NSS239del|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.NSS107del|TP53_uc010cng.1_In_Frame_Del_p.NSS107del|TP53_uc002gii.1_In_Frame_Del_p.NSS107del|TP53_uc010cnh.1_In_Frame_Del_p.NSS239del|TP53_uc010cni.1_In_Frame_Del_p.NSS239del|TP53_uc002gij.2_In_Frame_Del_p.NSS239del|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_In_Frame_Del_p.NSS146del|TP53_uc002gio.2_In_Frame_Del_p.NSS107del	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	239_241	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		S -> A (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(73)|p.N239D(31)|p.S241C(24)|p.N239S(19)|p.C242fs*5(15)|p.S240G(14)|p.N239fs*25(12)|p.S240R(8)|p.S241fs*6(8)|p.0?(7)|p.S241Y(7)|p.N239Y(6)|p.S241A(6)|p.S240I(6)|p.N239K(6)|p.S241del(5)|p.S241T(5)|p.N239T(4)|p.N239_C242delNSSC(3)|p.S240C(3)|p.S241S(3)|p.S241P(3)|p.N239_S240insX(2)|p.N239fs*8(2)|p.S240S(2)|p.S240T(2)|p.S240fs*7(2)|p.N239_S240delNS(2)|p.S241fs*22(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.N239fs*1(1)|p.N239_S240insN(1)|p.V225fs*23(1)|p.N239fs*6(1)|p.N239fs*4(1)|p.S240>CSC(1)|p.C238_M246delCNSSCMGGM(1)|p.S240P(1)|p.S241_C242insX(1)|p.M237_N239delMCN(1)|p.S240fs*23(1)|p.N239fs*26(1)|p.C238fs*21(1)|p.N239N(1)|p.H233fs*6(1)|p.S241fs*7(1)|p.S240fs*26(1)|p.N239*(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241fs*23(1)|p.S241_G245delSCMGG(1)|p.N239fs*0(1)|p.C238_N239insX(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGCCCATGCAGGAACTGTTACACATGTAG	0.574		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			-	7577566	-	-	7577558	7	5	49	1	0	1	0	1	0	0	0	0	16378	987	35	0	567	0	TP53	17	7577558	In_Frame_Del	DEL	GGAACTGTT	TCGA-06-0238-01A-02D-1492-08		7577558	73617652	39	3155											
ZNF317	57693	broad.mit.edu	37	chr19	9271619	9271619	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cttccgaaaccagtccatccTtaagactcacatgaactctc	4	15	2	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr19:9271619T>A	uc002mku.2	+	7	1573	c.1298T>A	c.(1297-1299)CTT>CAT	p.L433H	ZNF317_uc002mkv.2_Missense_Mutation_p.L292H|ZNF317_uc002mkw.2_Missense_Mutation_p.L401H|ZNF317_uc002mkx.2_Missense_Mutation_p.L348H|ZNF317_uc002mky.2_Missense_Mutation_p.L316H	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	433	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGTCCATCCTTAAGACTCAC	0.537													A	9271619	A	A	9271619	3	1	49	1	0	0	0	0	1	0	0	0	17832	1609	56	5	1320	5	ZNF317	19	9271619	Missense_Mutation	SNP	T	TCGA-06-0238-01A-02D-1492-08		9271619	49857364	40	3156											
NOTCH3	4854	broad.mit.edu	37	chr19	15298114	15298114	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcatgggtcaggggagcagtCgtccacgttgcgatcacaca	14	11	2	0			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr19:15298114C>T	uc002nan.2	-	11	1718	c.1642G>A	c.(1642-1644)GAC>AAC	p.D548N	NOTCH3_uc002nao.1_Missense_Mutation_p.D548N	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	548	Extracellular (Potential).|EGF-like 14; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GGGGAGCAGTCGTCCACGTTG	0.657													T	15298114	T	T	15298114	3	4	49	1	0	0	0	0	1	0	0	0	10550	884	31	2	5415	2	NOTCH3	19	15298114	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	6026495	15298114	43830869	41	3157											
FCGBP	8857	broad.mit.edu	37	chr19	40419695	40419695	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacacagtggcccagactggCctggcagcaggcagcggtca	14	14	1	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr19:40419695C>T	uc002omp.3	-	6	3307	c.3299G>A	c.(3298-3300)GGC>GAC	p.G1100D		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1100						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCCAGACTGGCCTGGCAGCAG	0.647													T	40419695	T	T	40419695	3	4	49	1	0	0	0	0	1	0	0	0	5778	739	26	3	13042	3	FCGBP	19	40419695	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	25121581	40419695	18709288	42	3158											
NLRP2	55655	broad.mit.edu	37	chr19	55494507	55494507	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtgcaggagtccgacctcCgtctgttcctggacggagac	15	12	1	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr19:55494507C>T	uc002qij.2	+	6	1527	c.1441C>T	c.(1441-1443)CGT>TGT	p.R481C	NLRP2_uc010yfp.1_Missense_Mutation_p.R458C|NLRP2_uc010esn.2_Missense_Mutation_p.R457C|NLRP2_uc010eso.2_Missense_Mutation_p.R478C|NLRP2_uc010esp.2_Missense_Mutation_p.R459C	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	481	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTCCGACCTCCGTCTGTTCCT	0.632													T	55494507	T	T	55494507	3	4	49	1	0	0	0	0	1	0	0	0	10477	652	23	2	1459	2	NLRP2	19	55494507	Missense_Mutation	SNP	C	TCGA-06-0238-01A-02D-1492-08	15074812	55494507	3634476	43	3159											
GGT1	2678	broad.mit.edu	37	chr22	25023517	25023517	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacacgccggatgacggggGcactgctcacctgtctgtcg	13	14	2	1			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chr22:25023517G>A	uc003aan.1	+	12	1626	c.1139G>A	c.(1138-1140)GGC>GAC	p.G380D	GGT1_uc003aas.1_Missense_Mutation_p.G380D|GGT1_uc003aat.1_Missense_Mutation_p.G380D|GGT1_uc003aau.1_Missense_Mutation_p.G380D|GGT1_uc003aav.1_Missense_Mutation_p.G380D|GGT1_uc003aaw.1_Missense_Mutation_p.G380D|GGT1_uc003aax.1_Missense_Mutation_p.G380D|GGT1_uc003aay.1_Missense_Mutation_p.G36D	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	380	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	GATGACGGGGGCACTGCTCAC	0.632													A	25023517	A	A	25023517	3	1	49	1	0	0	0	0	1	0	0	0	6361	1203	42	3	1169	3	GGT1	22	25023517	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08		25023517	26281049	44	3160											
MAP3K15	389840	broad.mit.edu	37	chrX	19431486	19431486	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctccttaccatttctgtggGtgagacatgccataaagaaa	8	10	1	2			TCGA-06-0238-01A-02D-1492-08	TCGA-06-0238-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	7e8c6b9f-0fec-49ea-9ecb-c9ba1fb4cb74	df9e1eb8-ba5f-4621-9b61-5283e3375482	g.chrX:19431486G>T	uc004czk.1	-	11	1651	c.14C>A	c.(13-15)ACC>AAC	p.T5N	MAP3K15_uc004czj.1_5'UTR	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	Error:Variant_position_missing_in_Q6ZN16_after_alignment							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					ATTTCTGTGGGTGAGACATGC	0.398													T	19431486	T	T	19431486	3	4	49	1	0	0	0	0	1	0	0	0	9249	1261	44	5	2330	5	MAP3K15	23	19431486	Missense_Mutation	SNP	G	TCGA-06-0238-01A-02D-1492-08		19431486	135839074	45	3161											
CCDC37	348807	broad.mit.edu	37	chr3	126133023	126133023	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcggaataaggctctctccGtgagtatccaggacagacgc	12	11	1	2	rs150312379	byFrequency	TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr3:126133023G>A	uc003eiu.1	+	4	324	c.225_splice	c.e4+1	p.S75_splice	CCDC37_uc010hsg.1_Splice_Site_p.S75_splice	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37											ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		GGCTCTCTCCGTGAGTATCCA	0.557													A	126133023	A	A	126133023	5	1	50	1	0	0	0	0	0	0	1	0	2809	1159	40	1	236	1	CCDC37	3	126133023	Splice_Site	SNP	G	TCGA-06-0240-01A-03D-1491-08		126133023	71889407	1	3162											
PCDHA1	56147	broad.mit.edu	37	chr5	140167216	140167216	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtccgtggaggtggccgaCgtgaatgacaacgcgcctgc	16	11	0	2			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr5:140167216C>T	uc003lhb.2	+	1	1341	c.1341C>T	c.(1339-1341)GAC>GAT	p.D447D	PCDHA1_uc003lha.2_Silent_p.D447D|PCDHA1_uc003lgz.2_Silent_p.D447D	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	447	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGGCCGACGTGAATGACA	0.667													T	140167216	T	T	140167216	2	4	50	1	0	0	0	0	0	0	0	1	11519	535	19	1		1	PCDHA1	5	140167216	Silent	SNP	C	TCGA-06-0240-01A-03D-1491-08		140167216	40748044	2	3163											
PPARGC1B	133522	broad.mit.edu	37	chr5	149210432	149210432	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctcagatctaaaagtcaaCggccttgtgttaaggtattt	9	8	3	1			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr5:149210432C>T	uc003lrc.2	+	4	610	c.568C>T	c.(568-570)CGG>TGG	p.R190W	PPARGC1B_uc003lrb.1_Missense_Mutation_p.R190W|PPARGC1B_uc003lrd.2_Intron|PPARGC1B_uc003lrf.2_Missense_Mutation_p.R169W|PPARGC1B_uc003lre.1_Missense_Mutation_p.R169W	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	190					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TAAAAGTCAACGGCCTTGTGT	0.562													T	149210432	T	T	149210432	3	4	50	1	0	0	0	0	1	0	0	0	12301	527	19	1	589	1	PPARGC1B	5	149210432	Missense_Mutation	SNP	C	TCGA-06-0240-01A-03D-1491-08	9043216	149210432	31704828	3	3164											
TDRD6	221400	broad.mit.edu	37	chr6	46658843	46658843	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaagaattagtttatataaCgcatattgatgacccttgga	8	5	0	4			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr6:46658843C>T	uc003oyj.2	+	1	2978	c.2978C>T	c.(2977-2979)ACG>ATG	p.T993M	TDRD6_uc010jze.2_Missense_Mutation_p.T987M	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	993					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GTTTATATAACGCATATTGAT	0.333													T	46658843	T	T	46658843	3	4	50	1	0	0	0	0	1	0	0	0	15731	536	19	1	2980	1	TDRD6	6	46658843	Missense_Mutation	SNP	C	TCGA-06-0240-01A-03D-1491-08		46658843	124456224	4	3165											
RAMP3	10268	broad.mit.edu	37	chr7	45222997	45222997	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtggcgcagcaaacgcaccGacacgctgctgtgagggtcc	14	13	0	1			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr7:45222997G>A	uc003tnb.2	+	3	494	c.433G>A	c.(433-435)GAC>AAC	p.D145N	RAMP3_uc003tnc.2_Missense_Mutation_p.D113N	NM_005856	NP_005847	O60896	RAMP3_HUMAN	receptor activity modifying protein 3 precursor	145	Cytoplasmic (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity				0					Pramlintide(DB01278)	CAAACGCACCGACACGCTGCT	0.627													A	45222997	A	A	45222997	3	1	50	1	0	0	0	0	1	0	0	0	13023	1058	37	2	443	2	RAMP3	7	45222997	Missense_Mutation	SNP	G	TCGA-06-0240-01A-03D-1491-08		45222997	113915666	5	3166											
TLR4	7099	broad.mit.edu	37	chr9	120466768	120466768	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggatgatgtctgcctcgcgCctggctgggactctgatccc	13	13	2	2			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr9:120466768C>G	uc004bjz.2	+	1	309	c.18C>G	c.(16-18)CGC>CGG	p.R6R	TLR4_uc004bka.2_5'UTR|TLR4_uc004bkb.2_5'UTR	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	6					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CTGCCTCGCGCCTGGCTGGGA	0.602													G	120466768	G	G	120466768	2	3	50	1	0	0	0	0	0	0	0	1	15950	726	26	5		5	TLR4	9	120466768	Silent	SNP	C	TCGA-06-0240-01A-03D-1491-08		120466768	20746663	6	3167											
MS4A8B	83661	broad.mit.edu	37	chr11	60470906	60470906	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcggctccatcatggcgaCggttctcgtaggggaatacc	12	13	2	0			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr11:60470906C>T	uc001npv.2	+	3	478	c.275C>T	c.(274-276)ACG>ATG	p.T92M	MS4A8B_uc009yne.1_Missense_Mutation_p.T92M	NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	92	Helical; (Potential).					integral to membrane	receptor activity				0						ATCATGGCGACGGTTCTCGTA	0.552													T	60470906	T	T	60470906	3	4	50	1	0	0	0	0	1	0	0	0	9867	536	19	1	281	1	MS4A8B	11	60470906	Missense_Mutation	SNP	C	TCGA-06-0240-01A-03D-1491-08		60470906	74535610	7	3168											
RYR3	6263	broad.mit.edu	37	chr15	34105755	34105755	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagtggtggcctgtttcaggAtggcccctctctacaacctg	11	13	2	0			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr15:34105755A>G	uc001zhi.2	+	74	10547	c.10477A>G	c.(10477-10479)ATG>GTG	p.M3493V	RYR3_uc010bar.2_Missense_Mutation_p.M3488V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3493					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGTTTCAGGATGGCCCCTCT	0.527													G	34105755	G	G	34105755	3	3	50	1	0	0	0	0	1	0	0	0	13770	333	12	4	10771	4	RYR3	15	34105755	Missense_Mutation	SNP	A	TCGA-06-0240-01A-03D-1491-08		34105755	68425637	8	3169											
THBS1	7057	broad.mit.edu	37	chr15	39874573	39874573	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagacctggtggatgctgtgCgggcagaaaagggtttcctc	15	8	0	2			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr15:39874573C>T	uc001zkh.2	+	3	426	c.247C>T	c.(247-249)CGG>TGG	p.R83W		NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	83	TSP N-terminal.|Heparin-binding.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GGATGCTGTGCGGGCAGAAAA	0.617													T	39874573	T	T	39874573	3	4	50	1	0	0	0	0	1	0	0	0	15850	759	27	1	253	1	THBS1	15	39874573	Missense_Mutation	SNP	C	TCGA-06-0240-01A-03D-1491-08	5768818	39874573	62656819	9	3170											
PAQR5	54852	broad.mit.edu	37	chr15	69652448	69652448	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctgaagctccccaggctgtTtagcatagaccagatacccc	8	15	0	3			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr15:69652448T>C	uc002arz.2	+	3	407	c.29T>C	c.(28-30)TTT>TCT	p.F10S	PAQR5_uc002asa.2_Missense_Mutation_p.F10S	NM_017705	NP_060175	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	10	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			ovary(2)	2						CCCAGGCTGTTTAGCATAGAC	0.542													C	69652448	C	C	69652448	3	2	50	1	0	0	0	0	1	0	0	0	11438	1841	64	4	31	4	PAQR5	15	69652448	Missense_Mutation	SNP	T	TCGA-06-0240-01A-03D-1491-08	29777875	69652448	32878944	10	3171											
CLEC3A	10143	broad.mit.edu	37	chr16	78064695	78064695	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggagtgatgaggcctgtcGcagcagcaagagatacatat	14	7	0	3			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr16:78064695G>A	uc002ffh.3	+	3	632	c.551G>A	c.(550-552)CGC>CAC	p.R184H		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	184	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						GAGGCCTGTCGCAGCAGCAAG	0.493													A	78064695	A	A	78064695	3	1	50	1	0	0	0	0	1	0	0	0	3510	1087	38	1	561	1	CLEC3A	16	78064695	Missense_Mutation	SNP	G	TCGA-06-0240-01A-03D-1491-08		78064695	12290058	11	3172											
HOXB5	3215	broad.mit.edu	37	chr17	46670992	46670992	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cataatttagcaactgatagTccgggccatttggataacgc	9	9	0	1			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr17:46670992T>C	uc002inr.2	-	1	112	c.53A>G	c.(52-54)GAC>GGC	p.D18G		NM_002147	NP_002138	P09067	HXB5_HUMAN	homeobox B5	18						nucleus	sequence-specific DNA binding				0						CAACTGATAGTCCGGGCCATT	0.507													C	46670992	C	C	46670992	3	2	50	1	0	0	0	0	1	0	0	0	7304	1667	58	4	764	4	HOXB5	17	46670992	Missense_Mutation	SNP	T	TCGA-06-0240-01A-03D-1491-08		46670992	34524218	12	3173											
FUT3	2525	broad.mit.edu	37	chr19	5844280	5844280	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caccgcccaggccaccagctCggtcttggccgagaggttga	13	15	1	2			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr19:5844280C>T	uc002mdk.2	-	2	668	c.571G>A	c.(571-573)GAG>AAG	p.E191K	FUT3_uc002mdm.2_Missense_Mutation_p.E191K|FUT3_uc002mdj.2_Missense_Mutation_p.E191K|FUT3_uc002mdl.2_Missense_Mutation_p.E191K	NM_001097641	NP_001091110	P21217	FUT3_HUMAN	fucosyltransferase 3	191	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity				0						GCCACCAGCTCGGTCTTGGCC	0.667													T	5844280	T	T	5844280	3	4	50	1	0	0	0	0	1	0	0	0	6105	893	31	2	518	2	FUT3	19	5844280	Missense_Mutation	SNP	C	TCGA-06-0240-01A-03D-1491-08		5844280	53284703	13	3174											
MUC16	94025	broad.mit.edu	37	chr19	9003616	9003616	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaacttcctggagccagggcGacgcatgtcctcctcatact	10	14	1	0			TCGA-06-0240-01A-03D-1491-08	TCGA-06-0240-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	20f74001-1cb8-451d-8173-5795fa93432b	276d21da-719b-4970-8733-aa745d09281a	g.chr19:9003616G>A	uc002mkp.2	-	49	40228	c.40024C>T	c.(40024-40026)CGC>TGC	p.R13342C	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.R159C|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13344	Extracellular (Potential).|SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGCCAGGGCGACGCATGTCC	0.552													A	9003616	A	A	9003616	3	1	50	1	0	0	0	0	1	0	0	0	9973	1058	37	2	3643	2	MUC16	19	9003616	Missense_Mutation	SNP	G	TCGA-06-0240-01A-03D-1491-08	3159336	9003616	50125367	14	3175											
MEGF6	1953	broad.mit.edu	37	chr1	3407152	3407152	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggaggcgggcagtgtgccCgctggggaaaaggagaaaag	19	7	0	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr1:3407152C>T	uc001akl.2	-	37	4793	c.4566G>A	c.(4564-4566)GCG>GCA	p.A1522A	MEGF6_uc001akk.2_Silent_p.A1210A	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	1522						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCAGTGTGCCCGCTGGGGAAA	0.672													T	3407152	T	T	3407152	2	4	51	1	0	0	0	0	0	0	0	1	9462	666	23	2		2	MEGF6	1	3407152	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08		3407152	245843469	1	3176											
PER3	8863	broad.mit.edu	37	chr1	7845640	7845640	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctccgctgtgtccacagcGttcaaggtaaacaagccgga	10	13	2	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr1:7845640G>A	uc001aoo.2	+	2	443	c.268G>A	c.(268-270)GTT>ATT	p.V90I	PER3_uc009vmg.1_Missense_Mutation_p.V90I|PER3_uc009vmh.1_Missense_Mutation_p.V90I|PER3_uc001aop.2_Missense_Mutation_p.V90I|PER3_uc010nzw.1_5'UTR|PER3_uc001aon.2_Missense_Mutation_p.V90I	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCCACAGCGTTCAAGGTAA	0.483													A	7845640	A	A	7845640	3	1	51	1	0	0	0	0	1	0	0	0	11731	1145	40	1	274	1	PER3	1	7845640	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	4438488	7845640	241404981	2	3177											
SLC2A7	155184	broad.mit.edu	37	chr1	9064868	9064868	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgagccagtgcactgccccGtccaccatgaaagctgcccg	11	16	0	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr1:9064868G>A	uc009vmo.1	-	11	1263	c.1263C>T	c.(1261-1263)GAC>GAT	p.D421D		NM_207420	NP_997303	Q6PXP3	GTR7_HUMAN	intestinal facilitative glucose transporter 7	421	Helical; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity				0	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		GCACTGCCCCGTCCACCATGA	0.652													A	9064868	A	A	9064868	2	1	51	1	0	0	0	0	0	0	0	1	14550	1136	40	1		1	SLC2A7	1	9064868	Silent	SNP	G	TCGA-06-0241-01A-02D-1491-08	1219228	9064868	240185753	3	3178											
CSF3R	1441	broad.mit.edu	37	chr1	36932400	36932400	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagcttggtgatgggtggcGtgccaaggccgggcagctgg	20	8	0	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr1:36932400G>A	uc001caw.1	-	17	2247	c.2069C>T	c.(2068-2070)ACG>ATG	p.T690M	MRPS15_uc001cas.2_5'Flank|CSF3R_uc001cat.1_Missense_Mutation_p.T252M|CSF3R_uc009vvc.1_Missense_Mutation_p.T219M|CSF3R_uc001cau.1_Missense_Mutation_p.T90M|CSF3R_uc001cav.1_Missense_Mutation_p.T690M|CSF3R_uc001cax.1_Missense_Mutation_p.T717M|CSF3R_uc001cay.1_Missense_Mutation_p.R659C	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	690	Cytoplasmic (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity	p.T717M(1)		central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	GATGGGTGGCGTGCCAAGGCC	0.612													A	36932400	A	A	36932400	3	1	51	1	0	0	0	0	1	0	0	0	3937	1145	40	1	554	1	CSF3R	1	36932400	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	27867532	36932400	212318221	4	3179											
DNALI1	7802	broad.mit.edu	37	chr1	38027710	38027710	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attggagacggaaaagagagAcctggagaggcaagtgaacg	16	5	0	5			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr1:38027710A>G	uc001cbj.2	+	5	681	c.671A>G	c.(670-672)GAC>GGC	p.D224G	DNALI1_uc010oie.1_RNA	NM_003462	NP_003453	O14645	IDLC_HUMAN	dynein, axonemal, light intermediate chain 1	202	Potential.				cellular component movement|single fertilization	axonemal dynein complex	microtubule motor activity			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAAAAGAGAGACCTGGAGAGG	0.557											OREG0013380	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	38027710	G	G	38027710	3	3	51	1	0	0	0	0	1	0	0	0	4659	275	10	4	689	4	DNALI1	1	38027710	Missense_Mutation	SNP	A	TCGA-06-0241-01A-02D-1491-08	1095310	38027710	211222911	5	3180											
FAM46C	54855	broad.mit.edu	37	chr1	118165644	118165644	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agataactctgaaggacatcGtccagaccgtccgcagtcgg	11	12	1	3			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr1:118165644G>A	uc001ehe.2	+	2	353	c.154G>A	c.(154-156)GTC>ATC	p.V52I		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	52											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		GAAGGACATCGTCCAGACCGT	0.567										Multiple Myeloma(3;1.13e-06)			A	118165644	A	A	118165644	3	1	51	1	0	0	0	0	1	0	0	0	5567	1145	40	1	156	1	FAM46C	1	118165644	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	80137934	118165644	131084977	6	3181											
ZNF697	90874	broad.mit.edu	37	chr1	120165750	120165750	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ggagcacatgtagggcttctCgcccgtgtgcacgcgctggt	15	12	1	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr1:120165750C>A	uc001ehy.1	-	3	1330	c.1216G>T	c.(1216-1218)GAG>TAG	p.E406*		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	406					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		TAGGGCTTCTCGCCCGTGTGC	0.672													A	120165750	A	A	120165750	4	1	51	1	0	0	0	0	0	1	0	0	18097	893	31	5	425	5	ZNF697	1	120165750	Nonsense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	2000106	120165750	129084871	7	3182											
AQP10	89872	broad.mit.edu	37	chr1	154294529	154294529	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatctacgtgggtggtaacGtctcaggtgaggagggtggg	18	7	2	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr1:154294529G>A	uc001feu.2	+	2	266	c.226G>A	c.(226-228)GTC>ATC	p.V76I	AQP10_uc001fev.2_Missense_Mutation_p.V76I	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	76	Cytoplasmic (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGGTGGTAACGTCTCAGGTGA	0.547													A	154294529	A	A	154294529	3	1	51	1	0	0	0	0	1	0	0	0	822	1145	40	1	232	1	AQP10	1	154294529	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	34128779	154294529	94956092	8	3183											
TMEM79	84283	broad.mit.edu	37	chr1	156255048	156255048	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggagaccctggccctactgGaagtgaagaggtctgattcc	13	10	1	4			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr1:156255048G>A	uc010phi.1	+	2	227	c.31G>A	c.(31-33)GAA>AAA	p.E11K	SMG5_uc001foc.3_5'Flank|TMEM79_uc001fod.2_5'UTR|TMEM79_uc009wrw.2_Missense_Mutation_p.E11K	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	11						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					GGCCCTACTGGAAGTGAAGAG	0.597													A	156255048	A	A	156255048	3	1	51	1	0	0	0	0	1	0	0	0	16200	1175	41	3	33	3	TMEM79	1	156255048	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	1960519	156255048	92995573	9	3184											
CD207	50489	broad.mit.edu	37	chr2	71060827	71060827	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaagctgccctggagtgccCggatctttgtatttaaagca	10	11	1	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr2:71060827C>T	uc002shg.2	-	3	562	c.515G>A	c.(514-516)CGG>CAG	p.R172Q		NM_015717	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 antigen, langerin	172	Potential.|Extracellular (Potential).				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			ovary(1)|lung(1)	2						CTGGAGTGCCCGGATCTTTGT	0.428													T	71060827	T	T	71060827	3	4	51	1	0	0	0	0	1	0	0	0	2983	652	23	2	487	2	CD207	2	71060827	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08		71060827	172138546	10	3185											
TBC1D8	11138	broad.mit.edu	37	chr2	101655055	101655055	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tggaaggccaccttgcttctGatactgacaatgatgggatg	12	8	1	3			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr2:101655055G>T	uc010fiv.2	-	7	1229	c.1098C>A	c.(1096-1098)ATC>ATA	p.I366I	TBC1D8_uc010yvw.1_Silent_p.I381I|TBC1D8_uc002tau.3_Silent_p.I123I	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	366					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CCTTGCTTCTGATACTGACAA	0.612													T	101655055	T	T	101655055	2	4	51	1	0	0	0	0	0	0	0	1	15622	1280	45	5		5	TBC1D8	2	101655055	Silent	SNP	G	TCGA-06-0241-01A-02D-1491-08	30594228	101655055	141544318	11	3186											
LRP1B	53353	broad.mit.edu	37	chr2	141597647	141597647	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtttccatcggtccagtAgagttttcttaattcaaaag	8	7	2	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr2:141597647A>T	uc002tvj.1	-	31	6094	c.5122T>A	c.(5122-5124)TAC>AAC	p.Y1708N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1708	Extracellular (Potential).|LDL-receptor class B 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCGGTCCAGTAGAGTTTTCTT	0.318										TSP Lung(27;0.18)			T	141597647	T	T	141597647	3	4	51	1	0	0	0	0	1	0	0	0	8955	420	15	5	8921	5	LRP1B	2	141597647	Missense_Mutation	SNP	A	TCGA-06-0241-01A-02D-1491-08	39942592	141597647	101601726	12	3187											
ARL8B	55207	broad.mit.edu	37	chr3	5214343	5214343	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttttaagttacatgatagAtgctgcagatcgtgaaaaga	9	4	0	5			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr3:5214343A>G	uc003bqg.2	+	4	511	c.290A>G	c.(289-291)GAT>GGT	p.D97G	ARL8B_uc011asx.1_Missense_Mutation_p.D88G|ARL8B_uc011asy.1_Missense_Mutation_p.D97G	NM_018184	NP_060654	Q9NVJ2	ARL8B_HUMAN	ADP-ribosylation factor-like 10C	97					cell cycle|cell division|chromosome segregation|small GTPase mediated signal transduction	late endosome membrane|lysosomal membrane|midbody|spindle midzone	alpha-tubulin binding|beta-tubulin binding|GDP binding|GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.0717)|Epithelial(13;0.0777)		TACATGATAGATGCTGCAGAT	0.323													G	5214343	G	G	5214343	3	3	51	1	0	0	0	0	1	0	0	0	947	333	12	4	304	4	ARL8B	3	5214343	Missense_Mutation	SNP	A	TCGA-06-0241-01A-02D-1491-08		5214343	192808087	13	3188											
ITGA9	3680	broad.mit.edu	37	chr3	37547525	37547525	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggccacttctctcacccGtccaccattgatgtggtagg	10	14	2	1	rs145062473		TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr3:37547525G>A	uc003chd.2	+	7	830	c.777G>A	c.(775-777)CCG>CCA	p.P259P	ITGA9_uc003chc.2_Silent_p.P259P	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	259	Extracellular (Potential).|FG-GAP 4.				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TCTCTCACCCGTCCACCATTG	0.537													A	37547525	A	A	37547525	2	1	51	1	0	0	0	0	0	0	0	1	7883	1132	40	1		1	ITGA9	3	37547525	Silent	SNP	G	TCGA-06-0241-01A-02D-1491-08	32333182	37547525	160474905	14	3189											
CELSR3	1951	broad.mit.edu	37	chr3	48679336	48679336	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgctcggcagagtggccgTtggaagcgcccccgcgtccg	16	15	0	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr3:48679336T>G	uc003cul.2	-	32	9053	c.8772A>C	c.(8770-8772)CAA>CAC	p.Q2924H	CELSR3_uc003cuf.1_Missense_Mutation_p.Q3022H|CELSR3_uc010hkf.2_Missense_Mutation_p.Q214H|CELSR3_uc010hkg.2_Missense_Mutation_p.Q907H	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2924	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGAGTGGCCGTTGGAAGCGCC	0.622													G	48679336	G	G	48679336	3	3	51	1	0	0	0	0	1	0	0	0	3223	1722	60	5	1182	5	CELSR3	3	48679336	Missense_Mutation	SNP	T	TCGA-06-0241-01A-02D-1491-08	11131811	48679336	149343094	15	3190											
MAGI1	9223	broad.mit.edu	37	chr3	65376868	65376868	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccagattttaaaaggatctgGttttttctggccagagctgt	10	7	2	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr3:65376868G>T	uc003dmn.2	-	14	2891	c.2365C>A	c.(2365-2367)CCA>ACA	p.P789T	MAGI1_uc003dmm.2_Missense_Mutation_p.P789T|MAGI1_uc003dmo.2_Missense_Mutation_p.P789T|MAGI1_uc003dmp.2_Missense_Mutation_p.P789T|MAGI1_uc010hnx.1_Missense_Mutation_p.P72T	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	789					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		AAAGGATCTGGTTTTTTCTGG	0.567													T	65376868	T	T	65376868	3	4	51	1	0	0	0	0	1	0	0	0	9190	1261	44	5	2297	5	MAGI1	3	65376868	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	16697532	65376868	132645562	16	3191											
HSPBAP1	79663	broad.mit.edu	37	chr3	122459902	122459902	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtggattctctgcagttttcAgggcacacacaagcatacgg	11	10	2	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr3:122459902A>G	uc003efu.1	-	7	1007	c.884T>C	c.(883-885)CTG>CCG	p.L295P	HSPBAP1_uc003eft.1_Missense_Mutation_p.L6P	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	295						cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		TGCAGTTTTCAGGGCACACAC	0.458													G	122459902	G	G	122459902	3	3	51	1	0	0	0	0	1	0	0	0	7425	188	7	4	590	4	HSPBAP1	3	122459902	Missense_Mutation	SNP	A	TCGA-06-0241-01A-02D-1491-08	57083034	122459902	75562528	17	3192											
YEATS2	55689	broad.mit.edu	37	chr3	183454552	183454552	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggctggggtgagtttcccGtcagagttcaagttcatttt	13	7	3	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr3:183454552G>A	uc003fly.2	+	8	1054	c.859G>A	c.(859-861)GTC>ATC	p.V287I		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	287	YEATS.				histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGAGTTTCCCGTCAGAGTTCA	0.418													A	183454552	A	A	183454552	3	1	51	1	0	0	0	0	1	0	0	0	17469	1145	40	1	885	1	YEATS2	3	183454552	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	60994650	183454552	14567878	18	3193											
PDGFRA	5156	broad.mit.edu	37	chr4	55133562	55133562	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaagacagtggagattacgAatgtgctgcccgccaggcta	13	9	0	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr4:55133562A>G	uc003han.3	+	6	1197	c.866A>G	c.(865-867)GAA>GGA	p.E289G	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.E183G|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	289	Ig-like C2-type 3.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GGAGATTACGAATGTGCTGCC	0.468			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			G	55133562	G	G	55133562	3	3	51	1	0	0	0	0	1	0	0	0	11661	246	9	4	884	4	PDGFRA	4	55133562	Missense_Mutation	SNP	A	TCGA-06-0241-01A-02D-1491-08		55133562	136020714	19	3194											
KDR	3791	broad.mit.edu	37	chr4	55955634	55955634	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tctttaccccaggatatggaGaagcacctagaataaaacag	8	9	1	2	rs138424770		TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr4:55955634G>A	uc003has.2	-	25	3613	c.3311C>T	c.(3310-3312)TCT>TTT	p.S1104F	KDR_uc003hat.1_Missense_Mutation_p.S1104F	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1104	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGGATATGGAGAAGCACCTAG	0.393			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			A	55955634	A	A	55955634	3	1	51	1	0	0	0	0	1	0	0	0	8139	942	33	3	783	3	KDR	4	55955634	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	822072	55955634	135198642	20	3195											
KIAA1109	84162	broad.mit.edu	37	chr4	123107257	123107257	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atttcatgtctataatcgctCggatctttatggacgccttc	7	10	3	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr4:123107257C>T	uc003ieh.2	+	5	470	c.425C>T	c.(424-426)TCG>TTG	p.S142L	KIAA1109_uc003iei.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	142					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TATAATCGCTCGGATCTTTAT	0.358													T	123107257	T	T	123107257	3	4	51	1	0	0	0	0	1	0	0	0	8208	893	31	2	443	2	KIAA1109	4	123107257	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	67151623	123107257	68047019	21	3196											
ANKRD50	57182	broad.mit.edu	37	chr4	125593092	125593092	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttgtgcttccaatggtgttAaattcttggcttgacaggta	10	7	1	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr4:125593092A>G	uc003ifg.3	-	3	1606	c.1340T>C	c.(1339-1341)TTA>TCA	p.L447S	ANKRD50_uc011cgo.1_Missense_Mutation_p.L268S|ANKRD50_uc010inw.2_Missense_Mutation_p.L447S	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	447										central_nervous_system(1)	1						CAATGGTGTTAAATTCTTGGC	0.388													G	125593092	G	G	125593092	3	3	51	1	0	0	0	0	1	0	0	0	677	372	13	4	2953	4	ANKRD50	4	125593092	Missense_Mutation	SNP	A	TCGA-06-0241-01A-02D-1491-08	2485835	125593092	65561184	22	3197											
SH3D19	152503	broad.mit.edu	37	chr4	152096196	152096196	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttcgtataaggccagggtttGgtttctttggcaattcaggt	12	6	2	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr4:152096196G>C	uc010ipl.1	-	7	1410	c.320C>G	c.(319-321)CCA>CGA	p.P107R	SH3D19_uc003imc.2_Missense_Mutation_p.P107R|SH3D19_uc003ime.2_Missense_Mutation_p.P107R|SH3D19_uc010ipm.2_Missense_Mutation_p.P107R	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a	107	Pro-rich.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				GCCAGGGTTTGGTTTCTTTGG	0.537													C	152096196	C	C	152096196	3	2	51	1	0	0	0	0	1	0	0	0	14249	1348	47	5	2112	5	SH3D19	4	152096196	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	26503104	152096196	39058080	23	3198											
PCDHA2	56146	broad.mit.edu	37	chr5	140176220	140176220	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcaggtgttcgtgctggaCgagaacgacaacgcgccggc	15	12	0	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr5:140176220C>T	uc003lhd.2	+	1	1777	c.1671C>T	c.(1669-1671)GAC>GAT	p.D557D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.D557D|PCDHA2_uc011czy.1_Silent_p.D557D	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	557	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTGCTGGACGAGAACGACA	0.687													T	140176220	T	T	140176220	2	4	51	1	0	0	0	0	0	0	0	1	11524	535	19	1		1	PCDHA2	5	140176220	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08		140176220	40739040	24	3199											
RBM27	54439	broad.mit.edu	37	chr5	145598558	145598558	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gtctaactagatgtgatgctGatccttcagccttagccaac	8	11	2	3			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr5:145598558G>A	uc003lnz.3	+	2	236	c.70G>A	c.(70-72)GAT>AAT	p.D24N	RBM27_uc003lny.2_Missense_Mutation_p.D24N	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	24					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGTGATGCTGATCCTTCAGC	0.333													A	145598558	A	A	145598558	3	1	51	1	0	0	0	0	1	0	0	0	13127	1290	45	3	76	3	RBM27	5	145598558	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	5422338	145598558	35316702	25	3200											
NDST1	3340	broad.mit.edu	37	chr5	149922522	149922522	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatggccacaactatcacaaAggcatcgactggtgagttgg	11	9	1	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr5:149922522A>G	uc003lsk.3	+	10	2461	c.1959A>G	c.(1957-1959)AAA>AAG	p.K653K	NDST1_uc011dcj.1_Silent_p.K653K	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	653	Heparan sulfate N-sulfotransferase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACTATCACAAAGGCATCGACT	0.567													G	149922522	G	G	149922522	2	3	51	1	0	0	0	0	0	0	0	1	10255	69	3	4		4	NDST1	5	149922522	Silent	SNP	A	TCGA-06-0241-01A-02D-1491-08	4323964	149922522	30992738	26	3201											
POU5F1	5460	broad.mit.edu	37	chr6	31133413	31133413	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagcaagggccgcagcttacAcatgttcttgaagctaagct	10	11	1	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr6:31133413A>G	uc003nsv.2	-	3	646	c.592T>C	c.(592-594)TGT>CGT	p.C198R	POU5F1_uc003nsu.2_Missense_Mutation_p.C103R|uc011dnf.1_5'Flank	NM_002701	NP_002692	Q01860	PO5F1_HUMAN	POU domain, class 5, transcription factor 1	198	POU-specific.				anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	skin(7)|salivary_gland(2)|bone(2)|lung(1)|ovary(1)	13						CGCAGCTTACACATGTTCTTG	0.547			T	EWSR1	sarcoma								G	31133413	G	G	31133413	3	3	51	1	0	0	0	0	1	0	0	0	12281	159	6	4	502	4	POU5F1	6	31133413	Missense_Mutation	SNP	A	TCGA-06-0241-01A-02D-1491-08		31133413	139981654	27	3202											
NEU1	4758	broad.mit.edu	37	chr6	31829050	31829050	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgctccaggaaacaccaTcatccttgctccataccaac	6	15	1	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr6:31829050T>C	uc003nxq.3	-	3	686	c.530A>G	c.(529-531)GAT>GGT	p.D177G	NEU1_uc010jtg.2_RNA|NEU1_uc003nxr.3_RNA|NEU1_uc010jth.2_Missense_Mutation_p.D8G|NEU1_uc003nxs.3_Missense_Mutation_p.D177G	NM_000434	NP_000425	Q99519	NEUR1_HUMAN	neuraminidase precursor	177	BNR 2.					cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			ovary(1)	1					Oseltamivir(DB00198)|Zanamivir(DB00558)	GGAAACACCATCATCCTTGCT	0.532													C	31829050	C	C	31829050	3	2	51	1	0	0	0	0	1	0	0	0	10341	1435	50	4	733	4	NEU1	6	31829050	Missense_Mutation	SNP	T	TCGA-06-0241-01A-02D-1491-08	695637	31829050	139286017	28	3203											
HIVEP2	3097	broad.mit.edu	37	chr6	143074691	143074691	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aacagccgaggagaggagggAgtgctaggtggaccagatga	18	6	0	3			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr6:143074691A>G	uc003qjd.2	-	10	7637	c.6894T>C	c.(6892-6894)ACT>ACC	p.T2298T		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	2298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GAGAGGAGGGAGTGCTAGGTG	0.527													G	143074691	G	G	143074691	2	3	51	1	0	0	0	0	0	0	0	1	7187	291	11	4		4	HIVEP2	6	143074691	Silent	SNP	A	TCGA-06-0241-01A-02D-1491-08	111245641	143074691	28040376	29	3204											
T	6862	broad.mit.edu	37	chr6	166571992	166571992	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggggagccccggaagaactgGgcccccagcccgttggacac	15	15	0	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr6:166571992G>T	uc003quu.1	-	9	1612	c.1119C>A	c.(1117-1119)GCC>GCA	p.A373A	T_uc003qut.1_Silent_p.A374A|T_uc003quv.1_Silent_p.A315A	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	373					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GGAAGAACTGGGCCCCCAGCC	0.692									Chordoma_Familial_Clustering_of				T	166571992	T	T	166571992	2	4	51	1	0	0	0	0	0	0	0	1	15485	1219	43	5		5	T	6	166571992	Silent	SNP	G	TCGA-06-0241-01A-02D-1491-08	23497301	166571992	4543075	30	3205											
MAGI2	9863	broad.mit.edu	37	chr7	77973153	77973153	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaatcacacttttcacctgCagaaactcatcaggctcgtc	7	13	4	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr7:77973153C>T	uc003ugx.2	-	9	1604	c.1350G>A	c.(1348-1350)CTG>CTA	p.L450L	MAGI2_uc003ugy.2_Silent_p.L450L|MAGI2_uc010ldx.1_Silent_p.L59L|MAGI2_uc010ldy.1_Silent_p.L59L|MAGI2_uc011kgr.1_Silent_p.L282L|MAGI2_uc011kgs.1_Silent_p.L287L	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	450	PDZ 2.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TTTTCACCTGCAGAAACTCAT	0.453													T	77973153	T	T	77973153	2	4	51	1	0	0	0	0	0	0	0	1	9191	697	25	3		3	MAGI2	7	77973153	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08		77973153	81165510	31	3206											
DNAJC2	27000	broad.mit.edu	37	chr7	102953526	102953526	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttctgttcttctgttgtccaAggggtgaagtctgtatatgg	12	6	4	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr7:102953526A>G	uc003vbo.2	-	16	1910	c.1659T>C	c.(1657-1659)CCT>CCC	p.P553P	PMPCB_uc003vbl.2_3'UTR|PMPCB_uc003vbm.2_3'UTR|PMPCB_uc010liv.2_3'UTR|PMPCB_uc010liw.2_3'UTR|PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.2_Silent_p.P178P|DNAJC2_uc010lix.2_Silent_p.P500P|DNAJC2_uc003vbp.2_Silent_p.P178P	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	553	SANT 2.				'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1						CTGTTGTCCAAGGGGTGAAGT	0.393													G	102953526	G	G	102953526	2	3	51	1	0	0	0	0	0	0	0	1	4639	59	3	4		4	DNAJC2	7	102953526	Silent	SNP	A	TCGA-06-0241-01A-02D-1491-08	24980373	102953526	56185137	32	3207											
RELN	5649	broad.mit.edu	37	chr7	103281043	103281043	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacagaatttgagacatgaCgggccaatataaactgtggg	12	6	0	3	rs146749232		TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr7:103281043C>T	uc003vca.2	-	17	2176	c.2016G>A	c.(2014-2016)CCG>CCA	p.P672P	RELN_uc010liz.2_Silent_p.P672P	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	672	EGF-like 1.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGAGACATGACGGGCCAATAT	0.368													T	103281043	T	T	103281043	2	4	51	1	0	0	0	0	0	0	0	1	13220	523	19	1		1	RELN	7	103281043	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08	327517	103281043	55857620	33	3208											
CNOT4	4850	broad.mit.edu	37	chr7	135047676	135047676	+	Frame_Shift_Del	DEL	G	-	-													gaactctgtagtaaatctgtGggggttttgctggggggtct							TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr7:135047676delG	uc011kpy.1	-	11	2195	c.2103delC	c.(2101-2103)CCCfs	p.P701fs	CNOT4_uc003vss.2_Frame_Shift_Del_p.P627fs|CNOT4_uc011kpz.1_Frame_Shift_Del_p.P698fs|CNOT4_uc003vst.2_Frame_Shift_Del_p.P630fs	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	370					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						GTAAATCTGTGGGGGTTTTGC	0.527													-	135047676	-	-	135047676	7	5	51	1	0	1	0	1	0	0	0	0	3621	1335	47	0	42	0	CNOT4	7	135047676	Frame_Shift_Del	DEL	G	TCGA-06-0241-01A-02D-1491-08	31766633	135047676	24090987	34	3209	3	2									
CNOT4	4850	broad.mit.edu	37	chr7	135047681	135047681	+	Frame_Shift_Del	DEL	T	-	-													ctgtagtaaatctgtgggggTtttgctggggggtctgaagg							TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr7:135047681delT	uc011kpy.1	-	11	2190	c.2098delA	c.(2098-2100)ACCfs	p.T700fs	CNOT4_uc003vss.2_Frame_Shift_Del_p.T626fs|CNOT4_uc011kpz.1_Frame_Shift_Del_p.T697fs|CNOT4_uc003vst.2_Frame_Shift_Del_p.T629fs	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						TCTGTGGGGGTTTTGCTGGGG	0.527													-	135047681	-	-	135047681	7	5	51	1	0	1	0	1	0	0	0	0	3621	1725	60	0	47	0	CNOT4	7	135047681	Frame_Shift_Del	DEL	T	TCGA-06-0241-01A-02D-1491-08	5	135047681	24090982	35	3210	3	2									
AGPAT6	137964	broad.mit.edu	37	chr8	41456786	41456786	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagtctcctttggtatccGcaaactctacatgaaaagtc	8	10	2	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr8:41456786G>A	uc003xnz.2	+	2	1067	c.128G>A	c.(127-129)CGC>CAC	p.R43H		NM_178819	NP_848934	Q86UL3	GPAT4_HUMAN	lysophosphatidic acid acyltransferase zeta	43					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity				0	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			TTTGGTATCCGCAAACTCTAC	0.433													A	41456786	A	A	41456786	3	1	51	1	0	0	0	0	1	0	0	0	391	1087	38	1	130	1	AGPAT6	8	41456786	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08		41456786	104907236	36	3211											
FAM83H	286077	broad.mit.edu	37	chr8	144808129	144808129	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtgcccaggatcttgggcaCgaacttgcccaccttgctgt	11	14	1	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr8:144808129C>T	uc003yzk.2	-	5	3571	c.3502G>A	c.(3502-3504)GTG>ATG	p.V1168M	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1168					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			ATCTTGGGCACGAACTTGCCC	0.647													T	144808129	T	T	144808129	3	4	51	1	0	0	0	0	1	0	0	0	5640	536	19	1	41	1	FAM83H	8	144808129	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	103351343	144808129	1555893	37	3212											
KIAA1432	57589	broad.mit.edu	37	chr9	5765489	5765489	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cactagaacaaggcaagtggGacctttgtcgacacatgatt	10	9	0	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr9:5765489G>A	uc003zji.2	+	19	2773	c.2680G>A	c.(2680-2682)GAC>AAC	p.D894N	KIAA1432_uc003zjh.2_Missense_Mutation_p.D894N|KIAA1432_uc003zjl.3_Missense_Mutation_p.D857N|KIAA1432_uc003zjj.1_Missense_Mutation_p.D436N|ERMP1_uc011lme.1_RNA	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	973						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		AGGCAAGTGGGACCTTTGTCG	0.448													A	5765489	A	A	5765489	3	1	51	1	0	0	0	0	1	0	0	0	8233	1174	41	3	2754	3	KIAA1432	9	5765489	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08		5765489	135447942	38	3213											
TESK1	7016	broad.mit.edu	37	chr9	35608190	35608190	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atgtgcctgctttccgaactCtggtgggggatgactgccca	13	11	1	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr9:35608190C>G	uc003zxa.2	+	8	1165	c.829C>G	c.(829-831)CTG>GTG	p.L277V	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Missense_Mutation_p.L117V	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	277	Protein kinase.				cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TTTCCGAACTCTGGTGGGGGA	0.597													G	35608190	G	G	35608190	3	3	51	1	0	0	0	0	1	0	0	0	15764	912	32	5	859	5	TESK1	9	35608190	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	29842701	35608190	105605241	39	3214											
OR13C8	138802	broad.mit.edu	37	chr9	107332367	107332367	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acaaggatgtaaaggctgctGtcaaaaacatactgtgtagg	11	6	1	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr9:107332367G>T	uc011lvo.1	+	1	919	c.919G>T	c.(919-921)GTC>TTC	p.V307F		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AAAGGCTGCTGTCAAAAACAT	0.373													T	107332367	T	T	107332367	3	4	51	1	0	0	0	0	1	0	0	0	10938	1377	48	5	921	5	OR13C8	9	107332367	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	71724177	107332367	33881064	40	3215											
ASS1	445	broad.mit.edu	37	chr9	133364801	133364801	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccatggaccgggaagtgcGcaaaatcaaacaaggcctgg	12	11	1	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr9:133364801G>A	uc004bzm.2	+	13	1276	c.920G>A	c.(919-921)CGC>CAC	p.R307H	ASS1_uc004bzn.2_Missense_Mutation_p.R307H|ASS1_uc010mza.2_Missense_Mutation_p.R383H|ASS1_uc004bzo.2_Missense_Mutation_p.R288H|ASS1_uc010mzb.2_Missense_Mutation_p.R345H|ASS1_uc004bzp.2_Missense_Mutation_p.R307H|ASS1_uc010mzc.2_Missense_Mutation_p.R307H	NM_000050	NP_000041	P00966	ASSY_HUMAN	argininosuccinate synthetase 1	307			R -> C (in CTLN1).		arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	CGGGAAGTGCGCAAAATCAAA	0.532													A	133364801	A	A	133364801	3	1	51	1	0	0	0	0	1	0	0	0	1061	1087	38	1	962	1	ASS1	9	133364801	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	26032434	133364801	7848630	41	3216											
SVIL	6840	broad.mit.edu	37	chr10	29839816	29839816	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatagtccttggattcaccGgcacaggtcctgagccccat	10	14	1	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr10:29839816G>A	uc001iut.1	-	6	1290	c.537C>T	c.(535-537)GCC>GCT	p.A179A	SVIL_uc001iuu.1_Silent_p.A179A|SVIL_uc009xld.1_Silent_p.A179A	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	179					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TGGATTCACCGGCACAGGTCC	0.557													A	29839816	A	A	29839816	2	1	51	1	0	0	0	0	0	0	0	1	15418	1103	39	2		2	SVIL	10	29839816	Silent	SNP	G	TCGA-06-0241-01A-02D-1491-08		29839816	105694931	42	3217											
MUC5B	727897	broad.mit.edu	37	chr11	1251288	1251288	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgccgtgccctggcacctGctctgtgcagggcggggccc	15	17	1	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr11:1251288G>A	uc009ycr.1	+	27	3377	c.3251G>A	c.(3250-3252)TGC>TAC	p.C1084Y	MUC5B_uc009yct.1_Missense_Mutation_p.C425Y|MUC5B_uc001ltb.2_Missense_Mutation_p.C428Y|MUC5B_uc001lta.2_Missense_Mutation_p.C93Y	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	425	VWFD 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCTGGCACCTGCTCTGTGCAG	0.652													A	1251288	A	A	1251288	3	1	51	1	0	0	0	0	1	0	0	0	9979	1319	46	3	1325	3	MUC5B	11	1251288	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08		1251288	133755228	43	3218											
NAV2	89797	broad.mit.edu	37	chr11	20099593	20099593	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgctaaagaaacagaacGcagctgcccaggctgccatt	10	12	0	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr11:20099593G>A	uc010rdm.1	+	26	5651	c.5290G>A	c.(5290-5292)GCA>ACA	p.A1764T	NAV2_uc001mpp.2_Missense_Mutation_p.A1644T|NAV2_uc001mpr.3_Missense_Mutation_p.A1708T|NAV2_uc001mpt.2_Missense_Mutation_p.A757T|NAV2_uc009yhx.2_Missense_Mutation_p.A772T|NAV2_uc009yhy.1_Missense_Mutation_p.A670T|NAV2_uc009yhz.2_Missense_Mutation_p.A353T|NAV2_uc001mpu.2_Missense_Mutation_p.A146T	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1764	Potential.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GAAACAGAACGCAGCTGCCCA	0.433													A	20099593	A	A	20099593	3	1	51	1	0	0	0	0	1	0	0	0	10184	1087	38	1	5325	1	NAV2	11	20099593	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	18848305	20099593	114906923	44	3219											
NOX4	50507	broad.mit.edu	37	chr11	89073272	89073272	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taaatctgcaaaccaacggaAggactggatatctctgcata	8	9	2	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr11:89073272A>C	uc001pct.2	-	15	1644	c.1405T>G	c.(1405-1407)TTC>GTC	p.F469V	NOX4_uc009yvr.2_Missense_Mutation_p.F444V|NOX4_uc001pcu.2_Missense_Mutation_p.F395V|NOX4_uc001pcw.2_Missense_Mutation_p.F162V|NOX4_uc001pcx.2_Missense_Mutation_p.F122V|NOX4_uc001pcv.2_Missense_Mutation_p.F429V|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Intron|NOX4_uc009yvp.2_Missense_Mutation_p.F233V|NOX4_uc010rtv.1_Missense_Mutation_p.F405V|NOX4_uc009yvq.2_Missense_Mutation_p.F445V	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	469	Cytoplasmic (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AACCAACGGAAGGACTGGATA	0.328													C	89073272	C	C	89073272	3	2	51	1	0	0	0	0	1	0	0	0	10558	72	3	5	347	5	NOX4	11	89073272	Missense_Mutation	SNP	A	TCGA-06-0241-01A-02D-1491-08	68973679	89073272	45933244	45	3220											
LRP1	4035	broad.mit.edu	37	chr12	57581183	57581183	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gccttcgagcgtgagaccgtCatcactatgtctggagatga	12	10	3	3			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr12:57581183C>T	uc001snd.2	+	42	7441	c.6975C>T	c.(6973-6975)GTC>GTT	p.V2325V		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2325	LDL-receptor class B 22.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GTGAGACCGTCATCACTATGT	0.612													T	57581183	T	T	57581183	2	4	51	1	0	0	0	0	0	0	0	1	8951	813	29	3		3	LRP1	12	57581183	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08		57581183	76270712	46	3221											
PCDH17	27253	broad.mit.edu	37	chr13	58207302	58207303	+	Frame_Shift_Ins	INS	-	A	A													ggaccgcgagcaacagaatcINSaccatacgctcgtgctgact							TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr13:58207302_58207303insA	uc001vhq.1	+	1	1514_1515	c.622_623insA	c.(622-624)CACfs	p.H208fs	PCDH17_uc010aec.1_Frame_Shift_Ins_p.H208fs	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	208	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCAACAGAATCACCATACGCTC	0.599													A	58207303	A	A	58207302	7	5	51	1	0	1	1	0	0	0	0	0	11512	826	29	0	624	0	PCDH17	13	58207302	Frame_Shift_Ins	INS	-	TCGA-06-0241-01A-02D-1491-08		58207302	56962576	47	3222											
MBIP	51562	broad.mit.edu	37	chr14	36789728	36789728	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cacctctcgggagaggttggGtctgcatcttcgctccaggt	13	12	3	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr14:36789728G>T	uc001wtm.2	-	1	155	c.67C>A	c.(67-69)CCC>ACC	p.P23T	MBIP_uc001wto.2_Missense_Mutation_p.P23T|MBIP_uc010tpy.1_5'UTR|MBIP_uc001wtn.2_Missense_Mutation_p.P23T	NM_016586	NP_057670	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1 isoform 1	23					histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		GAGAGGTTGGGTCTGCATCTT	0.587													T	36789728	T	T	36789728	3	4	51	1	0	0	0	0	1	0	0	0	9349	1261	44	5	1003	5	MBIP	14	36789728	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08		36789728	70559812	48	3223											
FBN1	2200	broad.mit.edu	37	chr15	48787734	48787734	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacaaataaaagagcctgggCtgttcttgcagactccatta	8	10	1	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr15:48787734C>T	uc001zwx.1	-	21	2799	c.2471G>A	c.(2470-2472)AGC>AAC	p.S824N		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	824	EGF-like 13; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGAGCCTGGGCTGTTCTTGCA	0.368													T	48787734	T	T	48787734	3	4	51	1	0	0	0	0	1	0	0	0	5702	797	28	3	6328	3	FBN1	15	48787734	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08		48787734	53743658	49	3224											
AKAP13	11214	broad.mit.edu	37	chr15	86123972	86123972	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatatcaaggggaacactgaCtcttccctgcaaagtgtggg	11	9	2	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr15:86123972C>T	uc002blv.1	+	7	2843	c.2673C>T	c.(2671-2673)GAC>GAT	p.D891D	AKAP13_uc002blt.1_Silent_p.D891D|AKAP13_uc002blu.1_Silent_p.D891D|AKAP13_uc010bne.1_5'Flank	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	891					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GGAACACTGACTCTTCCCTGC	0.512													T	86123972	T	T	86123972	2	4	51	1	0	0	0	0	0	0	0	1	449	564	20	3		3	AKAP13	15	86123972	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08	37336238	86123972	16407420	50	3225											
FANCI	55215	broad.mit.edu	37	chr15	89859631	89859631	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attctttccccttctagggcActgcatcagagcatggggga	11	11	3	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr15:89859631A>G	uc010bnp.1	+	38	4018	c.3928A>G	c.(3928-3930)ACT>GCT	p.T1310A	FANCI_uc002bnm.1_Missense_Mutation_p.T1250A|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.T1070A|FANCI_uc002bnq.1_Missense_Mutation_p.T723A|POLG_uc002bns.3_3'UTR|POLG_uc002bnr.3_3'UTR	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1310					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					CTTCTAGGGCACTGCATCAGA	0.398								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				G	89859631	G	G	89859631	3	3	51	1	0	0	0	0	1	0	0	0	5669	159	6	4	4074	4	FANCI	15	89859631	Missense_Mutation	SNP	A	TCGA-06-0241-01A-02D-1491-08	3735659	89859631	12671761	51	3226											
ITGAM	3684	broad.mit.edu	37	chr16	31308885	31308885	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgtggacgtggacagcaaCggcagcaccgacctggtcct	13	14	0	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr16:31308885C>T	uc002ebq.2	+	13	1505	c.1407C>T	c.(1405-1407)AAC>AAT	p.N469N	ITGAM_uc002ebr.2_Silent_p.N469N|ITGAM_uc010cam.1_Missense_Mutation_p.R73W|ITGAM_uc010can.2_Translation_Start_Site	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	469	FG-GAP 5.|Extracellular (Potential).|Potential.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						TGGACAGCAACGGCAGCACCG	0.637													T	31308885	T	T	31308885	2	4	51	1	0	0	0	0	0	0	0	1	7887	535	19	1		1	ITGAM	16	31308885	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08		31308885	59045868	52	3227											
NOL3	8996	broad.mit.edu	37	chr16	67208778	67208778	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ccgaggctgaagcagaaccaGagccggaactggagccagaa	14	11	0	4			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr16:67208778G>A	uc010vjd.1	+	3	733	c.726G>A	c.(724-726)CAG>CAA	p.Q242Q	NOL3_uc010vjc.1_Missense_Mutation_p.E246K|NOL3_uc002erp.2_Missense_Mutation_p.E184K			O60936	NOL3_HUMAN	RecName: Full=Nucleolar protein 3; AltName: Full=Apoptosis repressor with CARD; AltName: Full=Muscle-enriched cytoplasmic protein;          Short=Myp; AltName: Full=Nucleolar protein of 30 kDa;          Short=Nop30;	180					anti-apoptosis|apoptosis|mRNA processing|RNA splicing	cytosol|nucleolus	identical protein binding|RNA binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		agcagaaccagagccggaact	0.294													A	67208778	A	A	67208778	2	1	51	1	0	0	0	0	0	0	0	1	10523	943	33	3		3	NOL3	16	67208778	Silent	SNP	G	TCGA-06-0241-01A-02D-1491-08	35899893	67208778	23145975	53	3228											
KCTD19	146212	broad.mit.edu	37	chr16	67337179	67337179	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaggaagcagtagtgcacCtcctcttctgtgtctaacag	11	11	3	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr16:67337179C>T	uc002esu.2	-	4	564	c.513G>A	c.(511-513)GAG>GAA	p.E171E	KCTD19_uc002est.2_5'UTR|KCTD19_uc010vjj.1_5'UTR	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	171						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		AGTAGTGCACCTCCTCTTCTG	0.567													T	67337179	T	T	67337179	2	4	51	1	0	0	0	0	0	0	0	1	8106	680	24	3		3	KCTD19	16	67337179	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08	128401	67337179	23017574	54	3229											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577538	T	T	7577538	3	4	51	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08		7577538	73617672	55	3230											
THEG	51298	broad.mit.edu	37	chr19	367156	367156	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aagagggtggctggggccttCggctttgacaactggaggat	17	7	0	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr19:367156C>T	uc002lol.2	-	7	861	c.822G>A	c.(820-822)CCG>CCA	p.P274P	THEG_uc002lom.2_Silent_p.P250P	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	274	THEG 4.				cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGGGCCTTCGGCTTTGACA	0.572													T	367156	T	T	367156	2	4	51	1	0	0	0	0	0	0	0	1	15854	871	31	2		2	THEG	19	367156	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08		367156	58761827	56	3231											
ELSPBP1	64100	broad.mit.edu	37	chr19	48511941	48511941	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caagatgacccgatggtccaGttacctgttgggatggacaa	12	9	0	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr19:48511941G>C	uc002pht.2	+	2	172	c.17G>C	c.(16-18)AGT>ACT	p.S6T		NM_022142	NP_071425	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1 precursor	6					single fertilization	extracellular region					0		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		CGATGGTCCAGTTACCTGTTG	0.468													C	48511941	C	C	48511941	3	2	51	1	0	0	0	0	1	0	0	0	5083	1029	36	5	19	5	ELSPBP1	19	48511941	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	48144785	48511941	10617042	57	3232											
TNNT1	7138	broad.mit.edu	37	chr19	55648471	55648471	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagccccccacagcacctacCggagctgttcctcccccatg	8	20	0	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr19:55648471C>T	uc002qjb.3	-	11	700	c.611G>A	c.(610-612)CGG>CAG	p.R204Q	TNNT1_uc002qiz.3_Missense_Mutation_p.R134Q|TNNT1_uc002qja.3_Missense_Mutation_p.R134Q|TNNT1_uc002qjc.3_Missense_Mutation_p.R204Q|TNNT1_uc002qje.3_Missense_Mutation_p.R193Q|TNNT1_uc002qjd.3_Missense_Mutation_p.R193Q	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	204					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CAGCACCTACCGGAGCTGTTC	0.607													T	55648471	T	T	55648471	3	4	51	1	0	0	0	0	1	0	0	0	16327	666	23	2	241	2	TNNT1	19	55648471	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	7136530	55648471	3480512	58	3233											
PEG3	5178	broad.mit.edu	37	chr19	57327999	57327999	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggcctaaaggtttccccgCgctcacgttcacgttcacgt	10	14	3	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr19:57327999C>T	uc002qnu.2	-	7	2162	c.1811G>A	c.(1810-1812)CGC>CAC	p.R604H	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.R575H|PEG3_uc002qnv.2_Missense_Mutation_p.R604H|PEG3_uc002qnw.2_Missense_Mutation_p.R480H|PEG3_uc002qnx.2_Missense_Mutation_p.R478H|PEG3_uc010etr.2_Missense_Mutation_p.R604H	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	604					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R604H(1)		ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GGTTTCCCCGCGCtcacgttc	0.378													T	57327999	T	T	57327999	3	4	51	1	0	0	0	0	1	0	0	0	11720	768	27	1	2959	1	PEG3	19	57327999	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	1679528	57327999	1800984	59	3234											
CHD6	84181	broad.mit.edu	37	chr20	40045338	40045338	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggttaataccggggtggGcagtgtgcctgagggctcat	17	8	1	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr20:40045338G>A	uc002xka.1	-	33	6554	c.6376C>T	c.(6376-6378)CCC>TCC	p.P2126S	CHD6_uc002xjz.1_5'Flank	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2126					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				ACCGGGGTGGGCAGTGTGCCT	0.572													A	40045338	A	A	40045338	3	1	51	1	0	0	0	0	1	0	0	0	3329	1203	42	3	1791	3	CHD6	20	40045338	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08		40045338	22980182	60	3235											
L3MBTL	26013	broad.mit.edu	37	chr20	42163558	42163558	+	Frame_Shift_Del	DEL	G	-	-													ccggctggtgctccaagacaGgacatcccctgcagcctcct							TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr20:42163558delG	uc010zwh.1	+	16	1781	c.1735delG	c.(1735-1737)GGAfs	p.G579fs	L3MBTL_uc002xkl.2_Frame_Shift_Del_p.G511fs|L3MBTL_uc002xkm.2_Frame_Shift_Del_p.G511fs|L3MBTL_uc010ggl.2_Frame_Shift_Del_p.G511fs|L3MBTL_uc002xkn.1_Frame_Shift_Del_p.G270fs|L3MBTL_uc002xko.2_Frame_Shift_Del_p.G163fs	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	511	MBT 3.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CTCCAAGACAGGACATCCCCT	0.557													-	42163558	-	-	42163558	7	5	51	1	0	1	0	1	0	0	0	0	8591	1001	35	0	1581	0	L3MBTL	20	42163558	Frame_Shift_Del	DEL	G	TCGA-06-0241-01A-02D-1491-08	2118220	42163558	20861962	61	3236											
RTEL1	51750	broad.mit.edu	37	chr20	62326129	62326129	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaccacagtgggggtctggaGtgcccagagcagggaagcag	17	9	1	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chr20:62326129G>T	uc002yfu.1	+	32	3488	c.3145G>T	c.(3145-3147)GTG>TTG	p.V1049L	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.V1049L|RTEL1_uc011abd.1_Missense_Mutation_p.V1073L|RTEL1_uc011abe.1_Missense_Mutation_p.V826L|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Missense_Mutation_p.V294L|TNFRSF6B_uc002yfy.2_5'Flank|TNFRSF6B_uc002yfz.2_5'Flank	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	1049					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GGGGTCTGGAGTGCCCAGAGC	0.687													T	62326129	T	T	62326129	3	4	51	1	0	0	0	0	1	0	0	0	13720	1029	36	5	3267	5	RTEL1	20	62326129	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	20162571	62326129	699391	62	3237											
MAGEB4	4115	broad.mit.edu	37	chrX	30260976	30260976	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttatctttggggaacccCgaaagctcatcacccaagat	7	13	3	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:30260976C>T	uc004dcb.2	+	1	808	c.724C>T	c.(724-726)CGA>TGA	p.R242*	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	242	MAGE.									ovary(1)	1						TGGGGAACCCCGAAAGCTCAT	0.488													T	30260976	T	T	30260976	4	4	51	1	0	0	0	0	0	1	0	0	9178	644	23	2	726	2	MAGEB4	23	30260976	Nonsense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08		30260976	125009584	63	3238											
TAB3	257397	broad.mit.edu	37	chrX	30872355	30872355	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggttctggtgctgcagagCgctcttcttggtccactaaa	11	10	3	1			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:30872355C>T	uc004dcj.2	-	6	2090	c.1427G>A	c.(1426-1428)CGC>CAC	p.R476H	TAB3_uc004dck.2_Missense_Mutation_p.R476H|TAB3_uc010ngl.2_Missense_Mutation_p.R476H	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	476					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						TGCTGCAGAGCGCTCTTCTTG	0.443													T	30872355	T	T	30872355	3	4	51	1	0	0	0	0	1	0	0	0	15494	768	27	1	735	1	TAB3	23	30872355	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	611379	30872355	124398205	64	3239											
RGN	9104	broad.mit.edu	37	chrX	46951551	46951551	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tctgaaatgtatgtgacctgCgcccgggatgggatggaccc	14	10	1	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:46951551C>G	uc004dgz.1	+	7	1755	c.786C>G	c.(784-786)TGC>TGG	p.C262W	RGN_uc004dha.1_Missense_Mutation_p.C262W|RGN_uc010nho.1_Missense_Mutation_p.C209W|RGN_uc010nhp.1_Missense_Mutation_p.C190W	NM_152869	NP_690608	Q15493	RGN_HUMAN	regucalcin	262					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding				0						ATGTGACCTGCGCCCGGGATG	0.468													G	46951551	G	G	46951551	3	3	51	1	0	0	0	0	1	0	0	0	13282	776	27	5	804	5	RGN	23	46951551	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	16079196	46951551	108319009	65	3240											
USP11	8237	broad.mit.edu	37	chrX	47098522	47098522	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggcatacgtgcagggagGggaccaggactccagcacct	16	11	0	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:47098522G>A	uc004dhp.2	+	2	359	c.359G>A	c.(358-360)GGG>GAG	p.G120E	USP11_uc004dhq.2_5'UTR	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	120	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GTGCAGGGAGGGGACCAGGAC	0.557													A	47098522	A	A	47098522	3	1	51	1	0	0	0	0	1	0	0	0	17039	1232	43	3	365	3	USP11	23	47098522	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	146971	47098522	108172038	66	3241											
KLF8	11279	broad.mit.edu	37	chrX	56291902	56291902	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccagacccttgtggtgtccaCgtcaacatctgacatgagca	9	13	2	3	rs143280924		TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:56291902C>A	uc004dur.2	+	3	1317	c.371C>A	c.(370-372)ACG>AAG	p.T124K	KLF8_uc010nkg.2_Missense_Mutation_p.T119K|KLF8_uc011mop.1_Missense_Mutation_p.T124K|KLF8_uc010nkh.2_RNA	NM_007250	NP_009181	O95600	KLF8_HUMAN	Kruppel-like factor 8 isoform 1	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTGGTGTCCACGTCAACATCT	0.542													A	56291902	A	A	56291902	3	1	51	1	0	0	0	0	1	0	0	0	8352	536	19	5	381	5	KLF8	23	56291902	Missense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	9193380	56291902	98978658	67	3242											
UBQLN2	29978	broad.mit.edu	37	chrX	56592046	56592046	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cagctgccgaatccagaagtCagatttcagcaacaactgga	9	11	2	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:56592046C>T	uc004dus.2	+	1	1975	c.1740C>T	c.(1738-1740)GTC>GTT	p.V580V	UBQLN2_uc011moq.1_Silent_p.V468V	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	580						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						ATCCAGAAGTCAGATTTCAGC	0.512													T	56592046	T	T	56592046	2	4	51	1	0	0	0	0	0	0	0	1	16894	813	29	3		3	UBQLN2	23	56592046	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08	300144	56592046	98678514	68	3243											
MTMR8	55613	broad.mit.edu	37	chrX	63445208	63445208	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacagcagtgaaaagtggcGtctgtgccttgacatccaag	12	9	1	3			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:63445208G>A	uc011mou.1	-	10	1516	c.1448C>T	c.(1447-1449)ACG>ATG	p.T483M	ASB12_uc004dvp.1_Missense_Mutation_p.T99M|ASB12_uc004dvq.1_Missense_Mutation_p.T108M|ASB12_uc004dvr.1_Missense_Mutation_p.T108M	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	Error:Variant_position_missing_in_Q96EF0_after_alignment						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						GAAAAGTGGCGTCTGTGCCTT	0.517													A	63445208	A	A	63445208	3	1	51	1	0	0	0	0	1	0	0	0	9949	1145	40	1		1	MTMR8	23	63445208	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	6853162	63445208	91825352	69	3244											
KIF4A	24137	broad.mit.edu	37	chrX	69595167	69595167	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actaaaggaatccacagagcGtactgtctccaaactgaacc	7	12	1	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:69595167G>A	uc004dyg.2	+	17	2019	c.1892G>A	c.(1891-1893)CGT>CAT	p.R631H	KIF4A_uc010nkw.2_Missense_Mutation_p.R631H|KIF4A_uc004dyf.1_Missense_Mutation_p.R631H	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	631	Potential.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						TCCACAGAGCGTACTGTCTCC	0.423													A	69595167	A	A	69595167	3	1	51	1	0	0	0	0	1	0	0	0	8303	1145	40	1	1954	1	KIF4A	23	69595167	Missense_Mutation	SNP	G	TCGA-06-0241-01A-02D-1491-08	6149959	69595167	85675393	70	3245											
ATRX	546	broad.mit.edu	37	chrX	76937238	76937238	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttctttttagatgaagttctTtgcttcttctttttattatc	4	6	4	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:76937238T>C	uc004ecp.3	-	9	3742	c.3510A>G	c.(3508-3510)CAA>CAG	p.Q1170Q	ATRX_uc004ecq.3_Silent_p.Q1132Q|ATRX_uc004eco.3_Silent_p.Q955Q|ATRX_uc004ecr.2_Silent_p.Q1102Q|ATRX_uc010nlx.1_Silent_p.Q1141Q|ATRX_uc010nly.1_Silent_p.Q1115Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1170					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATGAAGTTCTTTGCTTCTTCT	0.348			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						C	76937238	C	C	76937238	2	2	51	1	0	0	0	0	0	0	0	1	1208	1838	64	4		4	ATRX	23	76937238	Silent	SNP	T	TCGA-06-0241-01A-02D-1491-08	7342071	76937238	78333322	71	3246											
GPR174	84636	broad.mit.edu	37	chrX	78427380	78427380	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcttgacccagtcatataCtacttttccactaatgagtt	5	10	2	2			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:78427380C>T	uc004edg.1	+	1	912	c.876C>T	c.(874-876)TAC>TAT	p.Y292Y		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	292	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						CAGTCATATACTACTTTTCCA	0.398										HNSCC(63;0.18)			T	78427380	T	T	78427380	2	4	51	1	0	0	0	0	0	0	0	1	6672	576	20	3		3	GPR174	23	78427380	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08	1490142	78427380	76843180	72	3247											
COL4A6	1288	broad.mit.edu	37	chrX	107412771	107412771	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cccggcttccctggagctccGatgccaattcctggatatcc	9	16	0	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:107412771G>A	uc004enw.3	-	37	3751	c.3648C>T	c.(3646-3648)ATC>ATT	p.I1216I	COL4A6_uc004env.3_Silent_p.I1215I|COL4A6_uc011msn.1_Silent_p.I1191I|COL4A6_uc010npk.2_Silent_p.I1191I	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1216	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CTGGAGCTCCGATGCCAATTC	0.577									Alport_syndrome_with_Diffuse_Leiomyomatosis				A	107412771	A	A	107412771	2	1	51	1	0	0	0	0	0	0	0	1	3695	1048	37	2		2	COL4A6	23	107412771	Silent	SNP	G	TCGA-06-0241-01A-02D-1491-08	28985391	107412771	47857789	73	3248											
SLC9A6	10479	broad.mit.edu	37	chrX	135081058	135081058	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctgatgaaggtaacgggaCaacttgcaggagatttttac	12	7	0	3			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:135081058C>T	uc004ezj.2	+	5	704	c.628C>T	c.(628-630)CAA>TAA	p.Q210*	SLC9A6_uc004ezk.2_Nonsense_Mutation_p.Q242*|SLC9A6_uc011mvx.1_Nonsense_Mutation_p.Q190*	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	210					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GGTAACGGGACAACTTGCAGG	0.353													T	135081058	T	T	135081058	4	4	51	1	0	0	0	0	0	1	0	0	14718	479	17	3	742	3	SLC9A6	23	135081058	Nonsense_Mutation	SNP	C	TCGA-06-0241-01A-02D-1491-08	27668287	135081058	20189502	74	3249											
PLXNB3	5365	broad.mit.edu	37	chrX	153033730	153033730	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgagtcgtacccctgtggCgacgagcacacccccagccc	10	20	0	0			TCGA-06-0241-01A-02D-1491-08	TCGA-06-0241-10A-01D-1491-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dd4035a-c800-41b0-85c9-02531d2910ed	4b352295-bcb7-457a-80a0-6369bb7f8ff9	g.chrX:153033730C>T	uc004fii.2	+	4	1287	c.1113C>T	c.(1111-1113)GGC>GGT	p.G371G	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Silent_p.G53G|PLXNB3_uc010nuk.2_Silent_p.G394G|PLXNB3_uc011mzd.1_Silent_p.G10G	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	371	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					ACCCCTGTGGCGACGAGCACA	0.687													T	153033730	T	T	153033730	2	4	51	1	0	0	0	0	0	0	0	1	12125	755	27	1		1	PLXNB3	23	153033730	Silent	SNP	C	TCGA-06-0241-01A-02D-1491-08	17952672	153033730	2236830	75	3250											
UBE4B	10277	broad.mit.edu	37	chr1	10192468	10192468	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	catagtattttgttaaatggCgaaacccgtgaggctgctct	10	8	1	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr1:10192468C>G	uc001aqs.3	+	15	2666	c.1953C>G	c.(1951-1953)GGC>GGG	p.G651G	UBE4B_uc001aqr.3_Silent_p.G522G|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Silent_p.G106G|UBE4B_uc001aqt.1_5'UTR	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	651					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TGTTAAATGGCGAAACCCGTG	0.373													G	10192468	G	G	10192468	2	3	52	1	0	0	0	0	0	0	0	1	16880	755	27	5		5	UBE4B	1	10192468	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08		10192468	239058153	1	3251											
GRIK3	2899	broad.mit.edu	37	chr1	37307528	37307528	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctgatttccgaaacatgaCgaagggctcctcctgcagag	11	11	1	3	rs114307108	by1000genomes	TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr1:37307528C>T	uc001caz.2	-	10	1474	c.1339G>A	c.(1339-1341)GTC>ATC	p.V447I	GRIK3_uc001cba.1_Missense_Mutation_p.V447I	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	447	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CGAAACATGACGAAGGGCTCC	0.577													T	37307528	T	T	37307528	3	4	52	1	0	0	0	0	1	0	0	0	6775	536	19	1	1448	1	GRIK3	1	37307528	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	27115060	37307528	211943093	2	3252											
C1orf175	374977	broad.mit.edu	37	chr1	55148429	55148429	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcctgaaggagaagcccGtcaccaaggagggccgggct	16	12	1	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr1:55148429G>A	uc010ooe.1	+	14	2806	c.2482G>A	c.(2482-2484)GTC>ATC	p.V828I	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.V396I|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.V346I|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.V828I|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_Intron|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Missense_Mutation_p.V30I	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	828						integral to membrane	binding				0						GGAGAAGCCCGTCACCAAGGA	0.622													A	55148429	A	A	55148429	3	1	52	1	0	0	0	0	1	0	0	0	2016	1145	40	1	2528	1	C1orf175	1	55148429	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	17840901	55148429	194102192	3	3253											
COL24A1	255631	broad.mit.edu	37	chr1	86340334	86340334	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcaagggggcactcacccGtaaacctggttccccagttc	9	14	2	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr1:86340334G>A	uc001dlj.2	-	35	3178	c.3136C>T	c.(3136-3138)CGG>TGG	p.R1046W	COL24A1_uc001dli.2_Missense_Mutation_p.R182W|COL24A1_uc010osd.1_Missense_Mutation_p.R346W|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1046	Collagen-like 9.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GCACTCACCCGTAAACCTGGT	0.408													A	86340334	A	A	86340334	3	1	52	1	0	0	0	0	1	0	0	0	3683	1144	40	1	2112	1	COL24A1	1	86340334	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	31191905	86340334	162910287	4	3254											
CFHR4	10877	broad.mit.edu	37	chr1	196884116	196884116	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaagtgtgggcctcctccacCtattagcaatggtgatacca	9	11	0	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr1:196884116C>A	uc001gto.2	+	5	716	c.647C>A	c.(646-648)CCT>CAT	p.P216H	CFHR4_uc009wyy.2_Missense_Mutation_p.P462H|CFHR4_uc001gtp.2_Missense_Mutation_p.P463H	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	216	Sushi 4.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						CCTCCTCCACCTATTAGCAAT	0.378													A	196884116	A	A	196884116	3	1	52	1	0	0	0	0	1	0	0	0	3287	681	24	5	665	5	CFHR4	1	196884116	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	110543782	196884116	52366505	5	3255											
CENPF	1063	broad.mit.edu	37	chr1	214815836	214815836	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtctttggctccattggaCgagagtaattcctacgagca	11	9	1	1	rs139914723	by1000genomes	TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr1:214815836C>T	uc001hkm.2	+	12	4329	c.4155C>T	c.(4153-4155)GAC>GAT	p.D1385D		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CTCCATTGGACGAGAGTAATT	0.423													T	214815836	T	T	214815836	2	4	52	1	0	0	0	0	0	0	0	1	3231	535	19	1		1	CENPF	1	214815836	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08	17931720	214815836	34434785	6	3256											
GKN1	56287	broad.mit.edu	37	chr2	69207121	69207121	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cccaaacaaagtcgatgaccTgagcaagttcggaaaaaaca	8	10	0	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr2:69207121T>A	uc002sfc.2	+	5	497	c.434T>A	c.(433-435)CTG>CAG	p.L145Q		NM_019617	NP_062563	Q9NS71	GKN1_HUMAN	18 kDa antrum mucosa protein precursor	145	BRICHOS.				digestion|positive regulation of cell division	extracellular region				breast(1)	1						GTCGATGACCTGAGCAAGTTC	0.502													A	69207121	A	A	69207121	3	1	52	1	0	0	0	0	1	0	0	0	6424	1580	55	5	452	5	GKN1	2	69207121	Missense_Mutation	SNP	T	TCGA-06-0644-01A-02D-1492-08		69207121	173992252	7	3257											
FAM123C	205147	broad.mit.edu	37	chr2	131520943	131520943	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccacgaccccagcgagggtcCtcttggccccagcccagatg	11	18	1	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr2:131520943C>A	uc002trw.2	+	2	1488	c.1298C>A	c.(1297-1299)CCT>CAT	p.P433H	FAM123C_uc010fmv.2_Missense_Mutation_p.P433H|FAM123C_uc010fms.1_Missense_Mutation_p.P433H|FAM123C_uc010fmt.1_Missense_Mutation_p.P433H|FAM123C_uc010fmu.1_Missense_Mutation_p.P433H	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	433										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AGCGAGGGTCCTCTTGGCCCC	0.657													A	131520943	A	A	131520943	3	1	52	1	0	0	0	0	1	0	0	0	5424	681	24	5	1300	5	FAM123C	2	131520943	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	62313822	131520943	111678430	8	3258											
LRIG1	26018	broad.mit.edu	37	chr3	66449417	66449417	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctccaggccttccagcccCgagaatgctctcttagccac	8	17	1	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr3:66449417C>T	uc003dmx.2	-	10	1223	c.1209G>A	c.(1207-1209)TCG>TCA	p.S403S	LRIG1_uc011bfu.1_Silent_p.S23S|LRIG1_uc003dmw.2_Silent_p.S69S|LRIG1_uc010hnz.2_Intron|LRIG1_uc010hoa.2_Silent_p.S427S	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	403	Extracellular (Potential).|LRR 14.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CTTCCAGCCCCGAGAATGCTC	0.522													T	66449417	T	T	66449417	2	4	52	1	0	0	0	0	0	0	0	1	8944	639	23	2		2	LRIG1	3	66449417	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08		66449417	131573013	9	3259											
FGFR3	2261	broad.mit.edu	37	chr4	1808950	1808951	+	Frame_Shift_Ins	INS	-	C	C													tgtttgcccacgacctgctgINScccccggccccacccagcag							TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr4:1808950_1808951insC	uc003gdr.3	+	18	2638_2639	c.2382_2383insC	c.(2380-2385)CTGCCCfs	p.L794fs	FGFR3_uc003gdu.2_Frame_Shift_Ins_p.L796fs|FGFR3_uc003gds.3_Frame_Shift_Ins_p.L682fs|FGFR3_uc003gdq.3_Frame_Shift_Ins_p.A772fs	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	794_795	Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.P795fs*139(1)|p.L794fs*23(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACGACCTGCTGCCCCCGGCCCC	0.688		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				C	1808951	C	C	1808950	7	5	52	1	0	1	1	0	0	0	0	0	5867	1306	46	0	2603	0	FGFR3	4	1808950	Frame_Shift_Ins	INS	-	TCGA-06-0644-01A-02D-1492-08		1808950	189345326	10	3260											
DRD5	1816	broad.mit.edu	37	chr4	9784011	9784011	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcgacgtctgggtggccttcGacatcatgtgctccactgcc	12	14	2	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr4:9784011G>A	uc003gmb.3	+	1	754	c.358G>A	c.(358-360)GAC>AAC	p.D120N		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	120	Helical; Name=3; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GGTGGCCTTCGACATCATGTG	0.617													A	9784011	A	A	9784011	3	1	52	1	0	0	0	0	1	0	0	0	4760	1058	37	2	360	2	DRD5	4	9784011	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	7975061	9784011	181370265	11	3261											
KIT	3815	broad.mit.edu	37	chr4	55561758	55561758	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatcagacttaatagtccgcGtgggcgacgagattaggctg	13	8	1	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr4:55561758G>A	uc010igr.2	+	2	235	c.148G>A	c.(148-150)GTG>ATG	p.V50M	KIT_uc010igs.2_Missense_Mutation_p.V50M	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	50	Extracellular (Potential).|Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.V50M(1)		soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AATAGTCCGCGTGGGCGACGA	0.468		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				A	55561758	A	A	55561758	3	1	52	1	0	0	0	0	1	0	0	0	8329	1145	40	1	154	1	KIT	4	55561758	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	45777747	55561758	135592518	12	3262											
SLC4A4	8671	broad.mit.edu	37	chr4	72338689	72338689	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgccacctgacccaggTgagggcattacgctttgtgt	13	10	0	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr4:72338689T>C	uc003hfy.2	+	14	2020	c.1903_splice	c.e14+2	p.A635_splice	SLC4A4_uc010iic.2_Splice_Site_p.A635_splice|SLC4A4_uc010iib.2_Splice_Site_p.A635_splice|SLC4A4_uc003hfz.2_Splice_Site_p.A635_splice|SLC4A4_uc003hgc.3_Splice_Site_p.A591_splice|SLC4A4_uc010iid.2_Intron|SLC4A4_uc003hga.2_Silent_p.G513G|SLC4A4_uc003hgb.3_Silent_p.G591G	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate							basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CTGACCCAGGTGAGGGCATTA	0.463													C	72338689	C	C	72338689	5	2	52	1	0	0	0	0	0	0	1	0	14656	1710	59	4	2076	4	SLC4A4	4	72338689	Splice_Site	SNP	T	TCGA-06-0644-01A-02D-1492-08	16776931	72338689	118815587	13	3263											
NUDT9	53343	broad.mit.edu	37	chr4	88362984	88362984	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttttttgtttttccagaaaTcctgcaggacggactggact	9	8	0	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr4:88362984T>C	uc003hqq.2	+	4	770	c.447T>C	c.(445-447)AAT>AAC	p.N149N	NUDT9_uc003hqr.2_Silent_p.N99N|NUDT9_uc010ikl.2_Silent_p.N117N	NM_024047	NP_076952	Q9BW91	NUDT9_HUMAN	nudix-type motif 9 isoform a	149						mitochondrion	ADP-ribose diphosphatase activity				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)		TTTCCAGAAATCCTGCAGGAC	0.418													C	88362984	C	C	88362984	2	2	52	1	0	0	0	0	0	0	0	1	10746	1432	50	4		4	NUDT9	4	88362984	Silent	SNP	T	TCGA-06-0644-01A-02D-1492-08	16024295	88362984	102791292	14	3264											
PRDM9	56979	broad.mit.edu	37	chr5	23524499	23524499	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctggtggccttccagtaccAcaggcagatcttctatagaa	9	12	2	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr5:23524499A>T	uc003jgo.2	+	10	1189	c.1007A>T	c.(1006-1008)CAC>CTC	p.H336L		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	336	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TTCCAGTACCACAGGCAGATC	0.537										HNSCC(3;0.000094)			T	23524499	T	T	23524499	3	4	52	1	0	0	0	0	1	0	0	0	12463	159	6	5	1041	5	PRDM9	5	23524499	Missense_Mutation	SNP	A	TCGA-06-0644-01A-02D-1492-08		23524499	157390761	15	3265											
CDH9	1007	broad.mit.edu	37	chr5	26906907	26906907	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcactatttccatagttggcGtcatctgcatctgttgcagt	9	10	3	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr5:26906907G>A	uc003jgs.1	-	4	733	c.564C>T	c.(562-564)GAC>GAT	p.D188D	CDH9_uc010iug.2_Silent_p.D188D	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	188	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CATAGTTGGCGTCATCTGCAT	0.403													A	26906907	A	A	26906907	2	1	52	1	0	0	0	0	0	0	0	1	3117	1136	40	1		1	CDH9	5	26906907	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08	3382408	26906907	154008353	16	3266											
FBN2	2201	broad.mit.edu	37	chr5	127712445	127712445	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	agtacagtaacgcccatttgGagccaagacaaatcctggtt	9	10	0	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr5:127712445G>C	uc003kuu.2	-	14	2390	c.1951C>G	c.(1951-1953)CCA>GCA	p.P651A	FBN2_uc003kuv.2_Missense_Mutation_p.P618A	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	651	EGF-like 9; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CGCCCATTTGGAGCCAAGACA	0.398													C	127712445	C	C	127712445	3	2	52	1	0	0	0	0	1	0	0	0	5703	1174	41	5	6995	5	FBN2	5	127712445	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	100805538	127712445	53202815	17	3267											
PCDHB11	56125	broad.mit.edu	37	chr5	140580521	140580521	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttccggaagacctcccattcGtgctaaaatcttcagttgag	8	11	2	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr5:140580521G>A	uc003liy.2	+	1	1174	c.1174G>A	c.(1174-1176)GTG>ATG	p.V392M	PCDHB11_uc011daj.1_Missense_Mutation_p.V27M	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	392	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCCCATTCGTGCTAAAATC	0.453													A	140580521	A	A	140580521	3	1	52	1	0	0	0	0	1	0	0	0	11536	1145	40	1	1176	1	PCDHB11	5	140580521	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	12868076	140580521	40334739	18	3268											
PRSS16	10279	broad.mit.edu	37	chr6	27219612	27219612	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcaagcagcattgcggacGgagctgagcgcttgcgggcc	16	12	1	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr6:27219612G>A	uc003nja.2	+	8	813	c.801G>A	c.(799-801)ACG>ACA	p.T267T	PRSS16_uc011dkt.1_Intron|PRSS16_uc003njb.2_Intron|PRSS16_uc010jqq.1_Intron|PRSS16_uc010jqr.1_Intron|PRSS16_uc003njc.1_Intron|PRSS16_uc003njd.2_RNA	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	267					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						CATTGCGGACGGAGCTGAGCG	0.697													A	27219612	A	A	27219612	2	1	52	1	0	0	0	0	0	0	0	1	12616	1103	39	2		2	PRSS16	6	27219612	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08		27219612	143895455	19	3269											
PIM1	5292	broad.mit.edu	37	chr6	37138555	37138557	+	In_Frame_Del	DEL	AGA	-	-													tccccctttcctaggcaaggAgaaggagcccctggagtcgc							TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr6:37138555_37138557delAGA	uc003onk.2	+	2	519_521	c.89_91delAGA	c.(88-93)GAGAAG>GAG	p.K31del	PIM1_uc011dtw.1_5'Flank	NM_002648	NP_002639	P11309	PIM1_HUMAN	non-specific serine/threonine protein kinase	122					cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	CTAGGCAAGGAGAAGGAGCCCCT	0.714			T	BCL6	NHL								-	37138557	-	-	37138555	7	5	52	1	0	1	0	1	0	0	0	0	11927	304	11	0	95	0	PIM1	6	37138555	In_Frame_Del	DEL	AGA	TCGA-06-0644-01A-02D-1492-08	9918943	37138555	133976512	20	3270											
KCNK5	8645	broad.mit.edu	37	chr6	39162433	39162433	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcacgtcccccgaagaacttGcccagggcactgatccacgt	10	16	0	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr6:39162433G>T	uc003oon.2	-	3	766	c.402C>A	c.(400-402)GGC>GGA	p.G134G		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	134	Cytoplasmic (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						CGAAGAACTTGCCCAGGGCAC	0.597													T	39162433	T	T	39162433	2	4	52	1	0	0	0	0	0	0	0	1	8069	1306	46	5		5	KCNK5	6	39162433	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08	2023878	39162433	131952634	21	3271											
HTR1E	3354	broad.mit.edu	37	chr6	87725488	87725488	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcgctgatgatccttaccGtctggaccatctccattttc	7	15	2	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr6:87725488G>A	uc003pli.2	+	2	1139	c.436G>A	c.(436-438)GTC>ATC	p.V146I		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	146	Helical; Name=4; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	GATCCTTACCGTCTGGACCAT	0.582													A	87725488	A	A	87725488	3	1	52	1	0	0	0	0	1	0	0	0	7439	1145	40	1	438	1	HTR1E	6	87725488	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	48563055	87725488	83389579	22	3272											
PTPRK	5796	broad.mit.edu	37	chr6	128319982	128319982	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtctggtaaggggattccgtCccctcacagaggtagcgagg	15	10	2	1	rs141454620	by1000genomes	TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr6:128319982C>T	uc003qbk.2	-	16	2926	c.2559G>A	c.(2557-2559)GGG>GGA	p.G853G	PTPRK_uc003qbj.2_Silent_p.G854G|PTPRK_uc010kfc.2_Silent_p.G854G|PTPRK_uc011ebu.1_Silent_p.G870G|PTPRK_uc010kfd.1_Silent_p.G79G	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	853	Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GGGATTCCGTCCCCTCACAGA	0.478													T	128319982	T	T	128319982	2	4	52	1	0	0	0	0	0	0	0	1	12805	842	30	3		3	PTPRK	6	128319982	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08	40594494	128319982	42795085	23	3273											
SKAP2	8935	broad.mit.edu	37	chr7	26766511	26766511	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaactacaacctgatatataCgtttatcaggagcagagatt	7	7	1	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr7:26766511C>T	uc003syc.2	-	7	877	c.584G>A	c.(583-585)CGT>CAT	p.R195H	SKAP2_uc011jzi.1_Missense_Mutation_p.R23H|SKAP2_uc011jzj.1_Missense_Mutation_p.R180H	NM_003930	NP_003921	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	195	PH.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			pancreas(1)	1						CTGATATATACGTTTATCAGG	0.303													T	26766511	T	T	26766511	3	4	52	1	0	0	0	0	1	0	0	0	14356	536	19	1	519	1	SKAP2	7	26766511	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08		26766511	132372152	24	3274											
TXNDC3	51314	broad.mit.edu	37	chr7	37901681	37901682	+	Frame_Shift_Ins	INS	-	C	C													aaatgcaccgcttgttaataINSaaaaagttattaatttgatc							TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr7:37901681_37901682insC	uc003tfn.2	+	7	694_695	c.322_323insC	c.(322-324)AAAfs	p.K108fs		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	108	Thioredoxin.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GCTTGTTAATAAAAAAGTTATT	0.376									Kartagener_syndrome				C	37901682	C	C	37901681	7	5	52	1	0	1	1	0	0	0	0	0	16795	363	13	0	340	0	TXNDC3	7	37901681	Frame_Shift_Ins	INS	-	TCGA-06-0644-01A-02D-1492-08	11135170	37901681	121236982	25	3275											
GRB10	2887	broad.mit.edu	37	chr7	50660761	50660761	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaatttggtgttcccgtcaTctaggctgaagaacgtctgc	11	9	3	3			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr7:50660761T>C	uc003tpi.2	-	16	1704	c.1673A>G	c.(1672-1674)GAT>GGT	p.D558G	GRB10_uc003tph.3_Missense_Mutation_p.D500G|GRB10_uc003tpj.2_Missense_Mutation_p.D512G|GRB10_uc003tpk.2_Missense_Mutation_p.D558G|GRB10_uc010kzb.2_Missense_Mutation_p.D500G|GRB10_uc003tpl.2_Missense_Mutation_p.D552G|GRB10_uc003tpm.2_Missense_Mutation_p.D500G|GRB10_uc003tpn.2_Missense_Mutation_p.D500G	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	558	SH2.				insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					GTTCCCGTCATCTAGGCTGAA	0.547									Russell-Silver_syndrome				C	50660761	C	C	50660761	3	2	52	1	0	0	0	0	1	0	0	0	6756	1435	50	4	115	4	GRB10	7	50660761	Missense_Mutation	SNP	T	TCGA-06-0644-01A-02D-1492-08	12759080	50660761	108477902	26	3276											
PCLO	27445	broad.mit.edu	37	chr7	82544904	82544904	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctaagctctctgtccctctaCgaaattcctgtttaatctga	5	12	3	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr7:82544904C>T	uc003uhx.2	-	7	12687	c.12398G>A	c.(12397-12399)CGT>CAT	p.R4133H	PCLO_uc003uhv.2_Missense_Mutation_p.R4133H|PCLO_uc010lec.2_Missense_Mutation_p.R1098H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4064					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGTCCCTCTACGAAATTCCTG	0.408													T	82544904	T	T	82544904	3	4	52	1	0	0	0	0	1	0	0	0	11583	536	19	1	3123	1	PCLO	7	82544904	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	31884143	82544904	76593759	27	3277											
ABCB4	5244	broad.mit.edu	37	chr7	87083895	87083895	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgcctggatttagcagcgaCaaggaaaagttcactaaatt	9	7	1	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr7:87083895C>T	uc003uiv.1	-	5	376	c.300G>A	c.(298-300)TTG>TTA	p.L100L	ABCB4_uc003uiw.1_Silent_p.L100L|ABCB4_uc003uix.1_Silent_p.L100L|ABCB4_uc003uiy.2_Silent_p.L100L	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	100	Extracellular (By similarity).|ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTAGCAGCGACAAGGAAAAGT	0.234													T	87083895	T	T	87083895	2	4	52	1	0	0	0	0	0	0	0	1	43	477	17	3		3	ABCB4	7	87083895	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08	4538991	87083895	72054768	28	3278											
RELN	5649	broad.mit.edu	37	chr7	103137114	103137114	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggctgccaccagcgaagtcGagttgtgttggtgagggcat	16	8	0	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr7:103137114G>A	uc003vca.2	-	56	9212	c.9052C>T	c.(9052-9054)CGA>TGA	p.R3018*	RELN_uc010liz.2_Nonsense_Mutation_p.R3018*	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3018					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGCGAAGTCGAGTTGTGTTG	0.478													A	103137114	A	A	103137114	4	1	52	1	0	0	0	0	0	1	0	0	13220	1066	37	2	1370	2	RELN	7	103137114	Nonsense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	16053219	103137114	56001549	29	3279											
BRAF	673	broad.mit.edu	37	chr7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acccactccatcgagatttcActgtagctagaccaaaatca	5	13	2	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				T	140453136	T	T	140453136	3	4	52	1	0	0	0	0	1	0	0	0	1496	159	6	5	517	5	BRAF	7	140453136	Missense_Mutation	SNP	A	TCGA-06-0644-01A-02D-1492-08	37316022	140453136	18685527	30	3280											
WDR86	349136	broad.mit.edu	37	chr7	151093239	151093239	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actccagacccgagctgtccGgtcataggagctgctgaaga	12	12	1	3			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr7:151093239G>A	uc003wkb.2	-	3	798	c.349C>T	c.(349-351)CGG>TGG	p.R117W	WDR86_uc003wka.2_Missense_Mutation_p.R75W|WDR86_uc011kvk.1_Missense_Mutation_p.R117W|WDR86_uc003wkc.2_5'UTR	NM_198285	NP_938026	Q86TI4	WDR86_HUMAN	WD repeat domain 86	117	WD 3.										0			OV - Ovarian serous cystadenocarcinoma(82;0.00419)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGAGCTGTCCGGTCATAGGAG	0.627													A	151093239	A	A	151093239	3	1	52	1	0	0	0	0	1	0	0	0	17331	1115	39	2	797	2	WDR86	7	151093239	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	10640103	151093239	8045424	31	3281											
RIMS2	9699	broad.mit.edu	37	chr8	104709403	104709403	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaagaacagaagggtgatgCgccaacctgtggtatctgcc	13	10	1	3			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr8:104709403C>T	uc003ylp.2	+	2	405	c.266C>T	c.(265-267)GCG>GTG	p.A89V		NM_001100117	NP_001093587	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	120	FYVE-type.|RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAGGGTGATGCGCCAACCTGT	0.438										HNSCC(12;0.0054)			T	104709403	T	T	104709403	3	4	52	1	0	0	0	0	1	0	0	0	13368	768	27	1	272	1	RIMS2	8	104709403	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08		104709403	41654619	32	3282											
PRSS3	5646	broad.mit.edu	37	chr9	33798043	33798043	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagctgctggcactgagtgCctcatctccggctggggcaa	13	14	2	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr9:33798043C>T	uc003ztj.3	+	3	588	c.588C>T	c.(586-588)TGC>TGT	p.C196C	uc003ztk.1_Intron|PRSS3_uc003zti.3_Silent_p.C153C|PRSS3_uc003ztl.3_Silent_p.C139C	NM_007343	NP_031369	P35030	TRY3_HUMAN	mesotrypsin isoform 1 preproprotein	196	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)			GCACTGAGTGCCTCATCTCCG	0.567													T	33798043	T	T	33798043	2	4	52	1	0	0	0	0	0	0	0	1	12622	747	26	3		3	PRSS3	9	33798043	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08		33798043	107415388	33	3283											
WNK2	65268	broad.mit.edu	37	chr9	96080166	96080166	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttgccagatggcgccctcGgaaccgcccggagaaaccag	12	16	0	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr9:96080166G>A	uc004ati.1	+	30	6751	c.6751G>A	c.(6751-6753)GGA>AGA	p.G2251R	WNK2_uc011lud.1_Intron|WNK2_uc004atj.2_Intron|WNK2_uc004atk.2_3'UTR	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	2251					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						TGGCGCCCTCGGAACCGCCCG	0.687													A	96080166	A	A	96080166	3	1	52	1	0	0	0	0	1	0	0	0	17375	1131	39	2		2	WNK2	9	96080166	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	62282123	96080166	45133265	34	3284											
SLC46A2	57864	broad.mit.edu	37	chr9	115652489	115652489	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggagcccagcgatcccagcGccatgaccccggaccagaag	12	16	0	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr9:115652489G>A	uc004bgk.2	-	1	705	c.473C>T	c.(472-474)GCG>GTG	p.A158V		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	158	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						CGATCCCAGCGCCATGACCCC	0.682													A	115652489	A	A	115652489	3	1	52	1	0	0	0	0	1	0	0	0	14645	1087	38	1	970	1	SLC46A2	9	115652489	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	19572323	115652489	25560942	35	3285											
OR1N2	138882	broad.mit.edu	37	chr9	125316158	125316158	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatcgtcttctcctatgtccGcattttctgggctgtgtttg	10	10	3	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr9:125316158G>A	uc011lyx.1	+	1	710	c.710G>A	c.(709-711)CGC>CAC	p.R237H		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						TCCTATGTCCGCATTTTCTGG	0.517													A	125316158	A	A	125316158	3	1	52	1	0	0	0	0	1	0	0	0	10970	1087	38	1	712	1	OR1N2	9	125316158	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	9663669	125316158	15897273	36	3286											
COL5A1	1289	broad.mit.edu	37	chr9	137622156	137622156	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gctgggaaggaagaggacgtCggcatcggggactatgacta	17	7	0	2	rs138702819	byFrequency	TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr9:137622156C>T	uc004cfe.2	+	7	1381	c.999C>T	c.(997-999)GTC>GTT	p.V333V		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	333	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AAGAGGACGTCGGCATCGGGG	0.622													T	137622156	T	T	137622156	2	4	52	1	0	0	0	0	0	0	0	1	3696	871	31	2		2	COL5A1	9	137622156	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08	12305998	137622156	3591275	37	3287											
RBP3	5949	broad.mit.edu	37	chr10	48389546	48389546	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaggcgtcagcaaaactatcGaagcgcaggtagcccacatt	11	11	1	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr10:48389546G>A	uc001jez.2	-	1	1446	c.1332C>T	c.(1330-1332)TTC>TTT	p.F444F		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	444	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CAAAACTATCGAAGCGCAGGT	0.617													A	48389546	A	A	48389546	2	1	52	1	0	0	0	0	0	0	0	1	13157	1049	37	2		2	RBP3	10	48389546	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08		48389546	87145201	38	3288											
PTEN	5728	broad.mit.edu	37	chr10	89711988	89711989	+	Frame_Shift_Del	DEL	TA	-	-													cacaagatgatgtttgaaacTattccaatgttcagtggcgg							TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr10:89711988_89711989delTA	uc001kfb.2	+	7	1637_1638	c.606_607delTA	c.(604-609)ACTATTfs	p.T202fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	202_203	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(3)|p.G165fs*9(3)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.T202I(1)|p.T202fs*19(1)|p.G165_K342del(1)|p.I203fs*39(1)|p.G165_*404del(1)|p.I203fs*18(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGTTTGAAACTATTCCAATGTT	0.371		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89711989	-	-	89711988	7	5	52	1	0	1	0	1	0	0	0	0	12738	1509	53	0	628	0	PTEN	10	89711988	Frame_Shift_Del	DEL	TA	TCGA-06-0644-01A-02D-1492-08	41322442	89711988	45822759	39	3289											
CTBP2	1488	broad.mit.edu	37	chr10	126691658	126691658	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggtacatcatggcgcccaCggcttcgtttagaacctgcg	12	12	1	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr10:126691658C>T	uc009yak.2	-	5	516	c.229G>A	c.(229-231)GTG>ATG	p.V77M	CTBP2_uc009yal.2_Missense_Mutation_p.V77M|CTBP2_uc001lif.3_Missense_Mutation_p.V77M|CTBP2_uc001lih.3_Missense_Mutation_p.V77M|CTBP2_uc001lid.3_Missense_Mutation_p.V145M|CTBP2_uc001lie.3_Missense_Mutation_p.V617M	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	77					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		ATGGCGCCCACGGCTTCGTTT	0.627													T	126691658	T	T	126691658	3	4	52	1	0	0	0	0	1	0	0	0	3998	536	19	1	1136	1	CTBP2	10	126691658	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	36979670	126691658	8843089	40	3290											
OR5M9	390162	broad.mit.edu	37	chr11	56230656	56230656	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagcattttgggggtaacGttggaggagaagcacacgtc	14	8	0	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr11:56230656G>A	uc010rjj.1	-	1	222	c.222C>T	c.(220-222)AAC>AAT	p.N74N		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	74	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TGGGGGTAACGTTGGAGGAGA	0.438													A	56230656	A	A	56230656	2	1	52	1	0	0	0	0	0	0	0	1	11177	1136	40	1		1	OR5M9	11	56230656	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08		56230656	78775860	41	3291											
B4GALNT3	283358	broad.mit.edu	37	chr12	657400	657400	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctctctcctcttccagtggCgacggaacgaccctggagcc	10	16	3	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr12:657400C>T	uc001qii.1	+	9	790	c.790C>T	c.(790-792)CGA>TGA	p.R264*	B4GALNT3_uc001qij.1_Nonsense_Mutation_p.R166*	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	264	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			CTTCCAGTGGCGACGGAACGA	0.582													T	657400	T	T	657400	4	4	52	1	0	0	0	0	0	1	0	0	1268	760	27	1	824	1	B4GALNT3	12	657400	Nonsense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08		657400	133194495	42	3292											
CHD4	1108	broad.mit.edu	37	chr12	6691851	6691851	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtaaaagcatcctgaggtgGcataccatatcgcataattg	9	8	0	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr12:6691851G>A	uc001qpn.2	-	28	4357	c.4279C>T	c.(4279-4281)CCA>TCA	p.P1427S	CHD4_uc001qpo.2_Missense_Mutation_p.P1434S|CHD4_uc001qpp.2_Missense_Mutation_p.P1459S|uc001qpq.1_Nonsense_Mutation_p.W18*|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1434					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TCCTGAGGTGGCATACCATAT	0.473													A	6691851	A	A	6691851	3	1	52	1	0	0	0	0	1	0	0	0	3327	1203	42	3	1486	3	CHD4	12	6691851	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	6034451	6691851	127160044	43	3293											
PIK3C2G	5288	broad.mit.edu	37	chr12	18716419	18716419	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcagaagcagtttgcatcaCtgactctcccagagtaaggc	9	11	3	3			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr12:18716419C>T	uc001rdt.2	+	27	3882	c.3766C>T	c.(3766-3768)CTG>TTG	p.L1256L	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Silent_p.L1297L|PIK3C2G_uc010sic.1_Silent_p.L1075L	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1256	PX.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GTTTGCATCACTGACTCTCCC	0.398													T	18716419	T	T	18716419	2	4	52	1	0	0	0	0	0	0	0	1	11911	564	20	3		3	PIK3C2G	12	18716419	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08	12024568	18716419	115135476	44	3294											
PDE3A	5139	broad.mit.edu	37	chr12	20522696	20522696	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggggtgcgcctgcctctgGctgtcgcgctgctggccgcc	16	17	1	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr12:20522696G>A	uc001reh.1	+	1	500	c.478G>A	c.(478-480)GCT>ACT	p.A160T		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	160	Helical; (Potential).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCTGCCTCTGGCTGTCGCGCT	0.701													A	20522696	A	A	20522696	3	1	52	1	0	0	0	0	1	0	0	0	11637	1203	42	3	480	3	PDE3A	12	20522696	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	1806277	20522696	113329199	45	3295											
C12orf12	196477	broad.mit.edu	37	chr12	91348191	91348191	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagggtgcaggccatacaccCgaaacacttgcaccgggcag	13	13	0	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr12:91348191C>T	uc001tbj.2	-	1	763	c.329G>A	c.(328-330)CGG>CAG	p.R110Q		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	110										central_nervous_system(1)|pancreas(1)	2						GCCATACACCCGAAACACTTG	0.647													T	91348191	T	T	91348191	3	4	52	1	0	0	0	0	1	0	0	0	1676	652	23	2	895	2	C12orf12	12	91348191	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	70825495	91348191	42503704	46	3296											
BTBD11	121551	broad.mit.edu	37	chr12	108013833	108013833	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cagcagcaccgcaggcctctCatccagtgcttgttaaagga	10	13	1	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr12:108013833C>A	uc001tmk.1	+	11	3044	c.2523C>A	c.(2521-2523)CTC>CTA	p.L841L	BTBD11_uc009zut.1_Silent_p.L722L|BTBD11_uc001tmj.2_Silent_p.L841L|BTBD11_uc001tml.1_Silent_p.L378L	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	841	ANK 5.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						GCAGGCCTCTCATCCAGTGCT	0.507													A	108013833	A	A	108013833	2	1	52	1	0	0	0	0	0	0	0	1	1539	813	29	5		5	BTBD11	12	108013833	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08	16665642	108013833	25838062	47	3297											
FAM48A	55578	broad.mit.edu	37	chr13	37607599	37607599	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caattaccgtttcattgggcGagtgttcatcttttgcttgt	9	8	3	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr13:37607599G>A	uc001uwg.2	-	10	942	c.694C>T	c.(694-696)CGC>TGC	p.R232C	FAM48A_uc010abt.2_Missense_Mutation_p.R233C|FAM48A_uc001uwh.2_Missense_Mutation_p.R233C|FAM48A_uc001uwi.2_Missense_Mutation_p.R232C|FAM48A_uc001uwj.2_Missense_Mutation_p.R233C|FAM48A_uc001uwk.2_Missense_Mutation_p.R232C|FAM48A_uc010tes.1_Missense_Mutation_p.R220C|FAM48A_uc001uwl.1_Missense_Mutation_p.R232C	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	232					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		TTCATTGGGCGAGTGTTCATC	0.428													A	37607599	A	A	37607599	3	1	52	1	0	0	0	0	1	0	0	0	5572	1058	37	2	1713	2	FAM48A	13	37607599	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08		37607599	77562279	48	3298											
MDP1	145553	broad.mit.edu	37	chr14	24683351	24683351	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattctggatgtgaatgcagGtaacacctagaaagataaga	10	6	1	4			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr14:24683351G>A	uc001wnl.1	-	6	490	c.410C>T	c.(409-411)ACC>ATC	p.T137I	TM9SF1_uc010tob.1_5'UTR|CHMP4A_uc001wni.2_5'Flank|CHMP4A_uc010toc.1_RNA|CHMP4A_uc001wnj.2_5'UTR|MDP1_uc001wnk.1_3'UTR|CHMP4A_uc001wnm.1_Silent_p.Y90Y	NM_138476	NP_612485	Q86V88	MGDP1_HUMAN	magnesium-dependent phosphatase 1	137							metal ion binding|protein tyrosine phosphatase activity				0						GTGAATGCAGGTAACACCTAG	0.433													A	24683351	A	A	24683351	3	1	52	1	0	0	0	0	1	0	0	0	9416	1261	44	3	124	3	MDP1	14	24683351	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08		24683351	82666189	49	3299											
RBM25	58517	broad.mit.edu	37	chr14	73578261	73578261	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccaatagtcctggtcagccTaattctgtgaagagaaagaa	9	8	2	3			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr14:73578261T>C	uc001xno.2	+	16	2251	c.2043T>C	c.(2041-2043)CCT>CCC	p.P681P	RBM25_uc010ttu.1_Silent_p.P681P|RBM25_uc001xnp.2_Silent_p.P476P	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	681					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		CTGGTCAGCCTAATTCTGTGA	0.388													C	73578261	C	C	73578261	2	2	52	1	0	0	0	0	0	0	0	1	13125	1509	53	4		4	RBM25	14	73578261	Silent	SNP	T	TCGA-06-0644-01A-02D-1492-08	48894910	73578261	33771279	50	3300											
EML5	161436	broad.mit.edu	37	chr14	89084607	89084607	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagtaattctgtcaatagcGgcatgatccataagatgttt	8	7	2	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr14:89084607G>A	uc001xxg.2	-	41	5793	c.5607C>T	c.(5605-5607)GCC>GCT	p.A1869A	EML5_uc001xxf.2_Silent_p.A656A|EML5_uc001xxd.2_Silent_p.A34A|EML5_uc001xxe.2_Silent_p.A218A	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1861						cytoplasm|microtubule				ovary(3)	3						TGTCAATAGCGGCATGATCCA	0.378													A	89084607	A	A	89084607	2	1	52	1	0	0	0	0	0	0	0	1	5100	1103	39	2		2	EML5	14	89084607	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08	15506346	89084607	18264933	51	3301											
SERPINA1	5265	broad.mit.edu	37	chr14	94847444	94847444	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtggaagtcctcttcctcGgtgtccttgacttcaaaggg	11	11	2	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr14:94847444G>A	uc001ycx.3	-	3	942	c.681C>T	c.(679-681)ACC>ACT	p.T227T	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Silent_p.T227T|SERPINA1_uc010aux.2_Silent_p.T227T|SERPINA1_uc001ycy.3_Silent_p.T227T|SERPINA1_uc010auy.2_Silent_p.T227T|SERPINA1_uc001ycz.3_Silent_p.T227T|SERPINA1_uc010auz.2_Silent_p.T227T|SERPINA1_uc010ava.2_Silent_p.T227T|SERPINA1_uc001ydb.3_Silent_p.T227T|SERPINA1_uc010avb.2_Silent_p.T227T|SERPINA1_uc001ydc.3_Silent_p.T227T|SERPINA1_uc001yda.1_Silent_p.T227T	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	227					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	CCTCTTCCTCGGTGTCCTTGA	0.517									Alpha-1-Antitrypsin_Deficiency				A	94847444	A	A	94847444	2	1	52	1	0	0	0	0	0	0	0	1	14086	1103	39	2		2	SERPINA1	14	94847444	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08	5762837	94847444	12502096	52	3302											
HHIPL1	84439	broad.mit.edu	37	chr14	100118715	100118715	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactgaccaggagctctgggCgctggagggcaaccttgcca	14	12	1	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr14:100118715C>T	uc010avs.2	+	2	475	c.410C>T	c.(409-411)GCG>GTG	p.A137V	HHIPL1_uc001ygl.1_Missense_Mutation_p.A137V	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	137					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				GAGCTCTGGGCGCTGGAGGGC	0.602													T	100118715	T	T	100118715	3	4	52	1	0	0	0	0	1	0	0	0	7093	768	27	1	416	1	HHIPL1	14	100118715	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	5271271	100118715	7230825	53	3303											
EIF2AK4	440275	broad.mit.edu	37	chr15	40247830	40247830	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tcttgttctaggaacgtttgGaaattgctagtttgtcaaac	9	6	3	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr15:40247830G>T	uc001zkm.1	+	6	654	c.604G>T	c.(604-606)GAA>TAA	p.E202*	EIF2AK4_uc001zkl.2_Nonsense_Mutation_p.E202*|EIF2AK4_uc010bbj.1_5'UTR	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	202					translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GGAACGTTTGGAAATTGCTAG	0.378													T	40247830	T	T	40247830	4	4	52	1	0	0	0	0	0	1	0	0	4999	1175	41	5	626	5	EIF2AK4	15	40247830	Nonsense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08		40247830	62283562	54	3304											
SPTBN5	51332	broad.mit.edu	37	chr15	42167085	42167085	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggatggccggggaggcgGccatgccatgggccatggag	19	11	0	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr15:42167085G>A	uc001zos.2	-	23	4685	c.4352C>T	c.(4351-4353)GCC>GTC	p.A1451V		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1486	Spectrin 11.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CGGGGAGGCGGCCATGCCATG	0.632													A	42167085	A	A	42167085	3	1	52	1	0	0	0	0	1	0	0	0	15121	1203	42	3	6751	3	SPTBN5	15	42167085	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	1919255	42167085	60364307	55	3305											
PIAS1	8554	broad.mit.edu	37	chr15	68468841	68468841	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctccacattggagcatcagGtagcgtctcaccaccagtcc	9	15	2	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr15:68468841G>T	uc002aqz.2	+	11	1426	c.1330G>T	c.(1330-1332)GTA>TTA	p.V444L	PIAS1_uc002ara.2_Missense_Mutation_p.V52L	NM_016166	NP_057250	O75925	PIAS1_HUMAN	protein inhibitor of activated STAT, 1	444					androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)	2						GGAGCATCAGGTAGCGTCTCA	0.423													T	68468841	T	T	68468841	3	4	52	1	0	0	0	0	1	0	0	0	11875	1261	44	5	1372	5	PIAS1	15	68468841	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	26301756	68468841	34062551	56	3306											
C15orf58	390637	broad.mit.edu	37	chr15	90784827	90784827	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacctggcccacagactgccCgtggagcaggcgccaagcga	13	15	0	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr15:90784827C>T	uc002bpc.2	+	4	866	c.687C>T	c.(685-687)CCC>CCT	p.P229P		NM_001013657	NP_001013679	Q6ZNW5	VTC2_HUMAN	hypothetical protein LOC390637	229					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity				0						ACAGACTGCCCGTGGAGCAGG	0.637													T	90784827	T	T	90784827	2	4	52	1	0	0	0	0	0	0	0	1	1806	639	23	2		2	C15orf58	15	90784827	Silent	SNP	C	TCGA-06-0644-01A-02D-1492-08	22315986	90784827	11746565	57	3307											
CDYL2	124359	broad.mit.edu	37	chr16	80718568	80718568	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctcatccttctcagagccGgcgtccccattttccatccc	5	19	2	1	rs149557557		TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr16:80718568G>A	uc002ffs.2	-	2	588	c.483C>T	c.(481-483)GCC>GCT	p.A161A		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	161						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						TCTCAGAGCCGGCGTCCCCAT	0.512													A	80718568	A	A	80718568	2	1	52	1	0	0	0	0	0	0	0	1	3186	1103	39	2		2	CDYL2	16	80718568	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08		80718568	9636185	58	3308											
TP53	7157	broad.mit.edu	37	chr17	7578190	7578190	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accagacctcaggcggctcaTagggcaccaccacactatgt	9	15	2	1	rs121912666		TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr17:7578190T>C	uc002gim.2	-	6	853	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(205)|p.Y220N(12)|p.Y220H(9)|p.Y220S(9)|p.0?(7)|p.Y220fs*27(4)|p.Y220*(3)|p.Y220D(2)|p.Y127C(2)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*1(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578190	C	C	7578190	3	2	52	1	0	0	0	0	1	0	0	0	16378	1406	49	4	635	4	TP53	17	7578190	Missense_Mutation	SNP	T	TCGA-06-0644-01A-02D-1492-08		7578190	73617020	59	3309											
ABCA10	10349	broad.mit.edu	37	chr17	67148603	67148603	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccctctccttgtttttaaCggtagcctgaagtatctgcc	8	13	2	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr17:67148603C>T	uc010dfa.1	-	36	5035	c.4156G>A	c.(4156-4158)GTT>ATT	p.V1386I	ABCA10_uc002jhz.2_5'Flank|ABCA10_uc010wqs.1_Missense_Mutation_p.V378I|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1386	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTGTTTTTAACGGTAGCCTGA	0.423													T	67148603	T	T	67148603	3	4	52	1	0	0	0	0	1	0	0	0	29	536	19	1	495	1	ABCA10	17	67148603	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	59570413	67148603	14046607	60	3310											
MYOM1	8736	broad.mit.edu	37	chr18	3134669	3134669	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgagcccttcacggggttgTtgttacagggctcccacttg	13	11	1	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr18:3134669T>C	uc002klp.2	-	16	2697	c.2363A>G	c.(2362-2364)AAC>AGC	p.N788S	MYOM1_uc002klq.2_Missense_Mutation_p.N788S	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	788	Fibronectin type-III 3.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CACGGGGTTGTTGTTACAGGG	0.577													C	3134669	C	C	3134669	3	2	52	1	0	0	0	0	1	0	0	0	10091	1725	60	4	2786	4	MYOM1	18	3134669	Missense_Mutation	SNP	T	TCGA-06-0644-01A-02D-1492-08		3134669	74942579	61	3311											
CDH7	1005	broad.mit.edu	37	chr18	63477003	63477003	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttgtcaggcgaaggggcaAgttccattttcattattgat	10	7	3	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr18:63477003A>G	uc002ljz.2	+	3	599	c.274A>G	c.(274-276)AGT>GGT	p.S92G	CDH7_uc002lka.2_Missense_Mutation_p.S92G|CDH7_uc002lkb.2_Missense_Mutation_p.S92G	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	92	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CGAAGGGGCAAGTTCCATTTT	0.448													G	63477003	G	G	63477003	3	3	52	1	0	0	0	0	1	0	0	0	3115	72	3	4	280	4	CDH7	18	63477003	Missense_Mutation	SNP	A	TCGA-06-0644-01A-02D-1492-08	60342334	63477003	14600245	62	3312											
REXO1	57455	broad.mit.edu	37	chr19	1816329	1816329	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagcacagacgtgtccaccaCggtgctgtggatgacctgtg	14	11	0	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr19:1816329C>T	uc002lua.3	-	15	3567	c.3472G>A	c.(3472-3474)GTG>ATG	p.V1158M	REXO1_uc010dsq.2_Missense_Mutation_p.V467M|REXO1_uc010xgs.1_Missense_Mutation_p.V144M|MIR1909_hsa-mir-1909|MI0008330_5'Flank	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	1158	Exonuclease.					nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGTCCACCACGGTGCTGTGG	0.682													T	1816329	T	T	1816329	3	4	52	1	0	0	0	0	1	0	0	0	13241	536	19	1	201	1	REXO1	19	1816329	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08		1816329	57312654	63	3313											
OR2Z1	284383	broad.mit.edu	37	chr19	8841802	8841802	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtatcctgtacttatgagaCgccaggtatgtctgctgatg	11	8	1	2	rs58741481	byFrequency	TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr19:8841802C>T	uc010xkg.1	+	1	412	c.412C>T	c.(412-414)CGC>TGC	p.R138C		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						ACTTATGAGACGCCAGGTATG	0.557													T	8841802	T	T	8841802	3	4	52	1	0	0	0	0	1	0	0	0	11036	536	19	1	414	1	OR2Z1	19	8841802	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	7025473	8841802	50287181	64	3314											
SARS2	54938	broad.mit.edu	37	chr19	39408375	39408375	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctccacaccggaagtgcaaGcccagctctgtcaagatctc	8	15	4	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr19:39408375G>A	uc002oka.2	-	12	1309	c.1149C>T	c.(1147-1149)GGC>GGT	p.G383G	SARS2_uc002ojz.2_Silent_p.G193G|SARS2_uc010xup.1_Silent_p.G385G|SARS2_uc002okb.2_Silent_p.G383G|SARS2_uc010xuq.1_Silent_p.G383G|SARS2_uc010xur.1_RNA	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	383					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GGAAGTGCAAGCCCAGCTCTG	0.627													A	39408375	A	A	39408375	2	1	52	1	0	0	0	0	0	0	0	1	13845	958	34	3		3	SARS2	19	39408375	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08	30566573	39408375	19720608	65	3315											
IL4I1	259307	broad.mit.edu	37	chr19	50397588	50397588	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttcctggggacgcaaggcGtagcccagcttctcgggcac	13	13	1	0	rs145616852	byFrequency	TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr19:50397588G>A	uc002pqt.1	-	5	582	c.504C>T	c.(502-504)TAC>TAT	p.Y168Y	IL4I1_uc002pqv.1_Silent_p.Y177Y|IL4I1_uc010eno.1_Silent_p.Y176Y|IL4I1_uc002pqw.1_Silent_p.Y176Y|IL4I1_uc002pqu.1_Silent_p.Y190Y	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	168						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		GACGCAAGGCGTAGCCCAGCT	0.602													A	50397588	A	A	50397588	2	1	52	1	0	0	0	0	0	0	0	1	7697	1140	40	1		1	IL4I1	19	50397588	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08	10989213	50397588	8731395	66	3316											
ZNF667	63934	broad.mit.edu	37	chr19	56953533	56953533	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttatatttatgtgttttcttTccattgtgaattttcttatg	5	4	2	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr19:56953533T>C	uc002qnd.2	-	5	993	c.831A>G	c.(829-831)GGA>GGG	p.G277G	ZNF667_uc010etl.2_Silent_p.G59G|ZNF667_uc002qne.2_Silent_p.G277G|ZNF667_uc010etm.2_Silent_p.G220G	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GTGTTTTCTTTCCATTGTGAA	0.348													C	56953533	C	C	56953533	2	2	52	1	0	0	0	0	0	0	0	1	18071	1770	62	4		4	ZNF667	19	56953533	Silent	SNP	T	TCGA-06-0644-01A-02D-1492-08	6555945	56953533	2175450	67	3317											
ZNF134	7693	broad.mit.edu	37	chr19	58131796	58131796	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaagtgttacagtatagaGcaacccttaagaagggataa	10	6	0	3			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr19:58131796G>A	uc002qpn.2	+	3	408	c.309G>A	c.(307-309)GAG>GAA	p.E103E	ZNF134_uc002qpo.2_5'UTR|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	103						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		ACAGTATAGAGCAACCCTTAA	0.458													A	58131796	A	A	58131796	2	1	52	1	0	0	0	0	0	0	0	1	17721	962	34	3		3	ZNF134	19	58131796	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08	1178263	58131796	997187	68	3318											
C20orf71	128861	broad.mit.edu	37	chr20	31814297	31814297	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cacacatggtagaaagtcagGtaagtttagaaaaaactttg	9	5	1	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr20:31814297G>T	uc002wyr.2	+	5	829	c.621_splice	c.e5+1	p.Q207_splice	C20orf71_uc002wys.2_Splice_Site_p.Q171_splice	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium							extracellular region	lipid binding			ovary(1)|skin(1)	2						AGAAAGTCAGGTAAGTTTAGA	0.348													T	31814297	T	T	31814297	5	4	52	1	0	0	0	0	0	0	1	0	2117	1275	44	5	640	5	C20orf71	20	31814297	Splice_Site	SNP	G	TCGA-06-0644-01A-02D-1492-08		31814297	31211223	69	3319											
PTPRT	11122	broad.mit.edu	37	chr20	41306674	41306674	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcccacgtgcctgtggtggTgcgatattccacttccttca	10	13	1	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr20:41306674T>C	uc002xkg.2	-	7	1169	c.985A>G	c.(985-987)ACC>GCC	p.T329A	PTPRT_uc010ggj.2_Missense_Mutation_p.T329A	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	329	Extracellular (Potential).|Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCTGTGGTGGTGCGATATTCC	0.557													C	41306674	C	C	41306674	3	2	52	1	0	0	0	0	1	0	0	0	12812	1696	59	4	3501	4	PTPRT	20	41306674	Missense_Mutation	SNP	T	TCGA-06-0644-01A-02D-1492-08	9492377	41306674	21718846	70	3320											
OLIG2	10215	broad.mit.edu	37	chr21	34399532	34399532	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagccgcgagcgcaagcgcaTgcacgacctcaacatcgcca	10	17	1	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr21:34399532T>A	uc002yqx.1	+	2	520	c.362T>A	c.(361-363)ATG>AAG	p.M121K		NM_005806	NP_005797	Q13516	OLIG2_HUMAN	oligodendrocyte lineage transcription factor 2	121	Helix-loop-helix motif.					cytoplasm|nucleus|plasma membrane	DNA binding			central_nervous_system(2)	2						CGCAAGCGCATGCACGACCTC	0.622			T	TRA@	T-ALL								A	34399532	A	A	34399532	3	1	52	1	0	0	0	0	1	0	0	0	10861	1464	51	5	364	5	OLIG2	21	34399532	Missense_Mutation	SNP	T	TCGA-06-0644-01A-02D-1492-08		34399532	13730363	71	3321											
COL6A2	1292	broad.mit.edu	37	chr21	47544566	47544566	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttcttgttccttctcaggCggatcctggtccccctggtg	11	13	2	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chr21:47544566C>T	uc002zia.1	+	22	1755	c.1673C>T	c.(1672-1674)GCG>GTG	p.A558V	COL6A2_uc002zhy.1_Missense_Mutation_p.A558V|COL6A2_uc002zhz.1_Missense_Mutation_p.A558V|COL6A2_uc002zib.1_5'UTR|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	558	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging	p.A558V(1)		central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCTTCTCAGGCGGATCCTGGT	0.672													T	47544566	T	T	47544566	3	4	52	1	0	0	0	0	1	0	0	0	3700	782	27	1	1755	1	COL6A2	21	47544566	Missense_Mutation	SNP	C	TCGA-06-0644-01A-02D-1492-08	13145034	47544566	585329	72	3322											
MXRA5	25878	broad.mit.edu	37	chrX	3229308	3229308	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctccctcatccccacttcGttaaagtagagtgtcccatt	5	15	1	1			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chrX:3229308G>A	uc004crg.3	-	7	7093	c.6936C>T	c.(6934-6936)AAC>AAT	p.N2312N		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2312	Ig-like C2-type 7.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCCCCACTTCGTTAAAGTAGA	0.547													A	3229308	A	A	3229308	2	1	52	1	0	0	0	0	0	0	0	1	10003	1136	40	1		1	MXRA5	23	3229308	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08		3229308	152041252	73	3323											
TLR8	51311	broad.mit.edu	37	chrX	12939911	12939911	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aaaacgttctcctttgtctaGaggagagggattgggatccg	13	7	2	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chrX:12939911G>A	uc004cve.2	+	2	2820	c.2752G>A	c.(2752-2754)GAG>AAG	p.E918K	TLR8_uc004cvd.2_Missense_Mutation_p.E936K	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	918	Cytoplasmic (Potential).|TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						CCTTTGTCTAGAGGAGAGGGA	0.443													A	12939911	A	A	12939911	3	1	52	1	0	0	0	0	1	0	0	0	15954	943	33	3	2758	3	TLR8	23	12939911	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	9710603	12939911	142330649	74	3324											
OTUD6A	139562	broad.mit.edu	37	chrX	69282717	69282717	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gccaggagagcatcttccagGctgagatgtcggagcacctg	14	11	1	2			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chrX:69282717G>C	uc004dxu.1	+	1	377	c.343G>C	c.(343-345)GCT>CCT	p.A115P		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	115										lung(1)|skin(1)	2						CATCTTCCAGGCTGAGATGTC	0.617													C	69282717	C	C	69282717	3	2	52	1	0	0	0	0	1	0	0	0	11316	1203	42	5	345	5	OTUD6A	23	69282717	Missense_Mutation	SNP	G	TCGA-06-0644-01A-02D-1492-08	56342806	69282717	85987843	75	3325											
CXorf57	55086	broad.mit.edu	37	chrX	105855511	105855511	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcaccccctcggaggtggtGcctgtaactgtgctggccgt	14	13	1	0			TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chrX:105855511G>A	uc004emi.3	+	1	352	c.201G>A	c.(199-201)GTG>GTA	p.V67V	CXorf57_uc004emj.3_Silent_p.V67V|CXorf57_uc004emh.2_Silent_p.V67V	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	67										ovary(1)|lung(1)|breast(1)	3						CGGAGGTGGTGCCTGTAACTG	0.572													A	105855511	A	A	105855511	2	1	52	1	0	0	0	0	0	0	0	1	4113	1306	46	3		3	CXorf57	23	105855511	Silent	SNP	G	TCGA-06-0644-01A-02D-1492-08	36572794	105855511	49415049	76	3326											
PCDH11Y	83259	broad.mit.edu	37	chrY	4967730	4967730	+	Frame_Shift_Del	DEL	T	-	-													tgtcaatgacaacaaaccagTtttcattgtccctccttaca							TCGA-06-0644-01A-02D-1492-08	TCGA-06-0644-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	2553c4d2-5f6a-4eba-84b6-04c4761ebf5c	1d3f3beb-1389-4062-99f3-811b08c4f174	g.chrY:4967730delT	uc004fqo.2	+	2	2845	c.2111delT	c.(2110-2112)GTTfs	p.V704fs	PCDH11Y_uc010nwg.1_Frame_Shift_Del_p.V693fs|PCDH11Y_uc004fql.1_Frame_Shift_Del_p.V693fs|PCDH11Y_uc004fqm.1_Frame_Shift_Del_p.V693fs|PCDH11Y_uc004fqn.1_Frame_Shift_Del_p.V704fs|PCDH11Y_uc004fqp.1_Frame_Shift_Del_p.V475fs	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	704	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						AACAAACCAGTTTTCATTGTC	0.403													-	4967730	-	-	4967730	7	5	52	1	0	1	0	1	0	0	0	0	11509	1725	60	0	2153	0	PCDH11Y	24	4967730	Frame_Shift_Del	DEL	T	TCGA-06-0644-01A-02D-1492-08		4967730	54405836	77	3327											
KIAA1751	85452	broad.mit.edu	37	chr1	1888126	1888126	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggcaggaacttgaaagtcGtgcccaagcccccaacgttg	11	13	0	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr1:1888126G>A	uc001aim.1	-	17	2105	c.1949C>T	c.(1948-1950)ACG>ATG	p.T650M	KIAA1751_uc009vkz.1_Missense_Mutation_p.T650M	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	650										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CTTGAAAGTCGTGCCCAAGCC	0.582													A	1888126	A	A	1888126	3	1	53	1	0	0	0	0	1	0	0	0	8256	1145	40	1	347	1	KIAA1751	1	1888126	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08		1888126	247362495	1	3328											
TAS1R2	80834	broad.mit.edu	37	chr1	19166593	19166593	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgtagggcccctggtagcGgacccagtagctgtaggcgc	16	12	0	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr1:19166593G>A	uc001bba.1	-	6	2021	c.2020C>T	c.(2020-2022)CGC>TGC	p.R674C		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	674	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CCCTGGTAGCGGACCCAGTAG	0.572													A	19166593	A	A	19166593	3	1	53	1	0	0	0	0	1	0	0	0	15560	1116	39	2	503	2	TAS1R2	1	19166593	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	17278467	19166593	230084028	2	3329											
GRHL3	57822	broad.mit.edu	37	chr1	24657929	24657929	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattcagtttcaggtctgtgCggctgctaaagaacgaccca	10	11	3	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr1:24657929C>T	uc001biy.2	+	2	92	c.46C>T	c.(46-48)CGG>TGG	p.R16W	GRHL3_uc001bix.2_Missense_Mutation_p.R11W|GRHL3_uc001biz.2_Intron	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	11					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CAGGTCTGTGCGGCTGCTAAA	0.512													T	24657929	T	T	24657929	3	4	53	1	0	0	0	0	1	0	0	0	6765	759	27	1	73	1	GRHL3	1	24657929	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	5491336	24657929	224592692	3	3330											
KPRP	448834	broad.mit.edu	37	chr1	152732729	152732729	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctgtttccctcagtatcGgtcccggacttcatttagtc	8	13	2	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr1:152732729G>A	uc001fal.1	+	2	723	c.665G>A	c.(664-666)CGG>CAG	p.R222Q		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	222						cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCAGTATCGGTCCCGGACT	0.582													A	152732729	A	A	152732729	3	1	53	1	0	0	0	0	1	0	0	0	8436	1116	39	2	667	2	KPRP	1	152732729	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	128074800	152732729	96517892	4	3331											
OR2L8	391190	broad.mit.edu	37	chr1	248112496	248112496	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taggaggtgcagaagcactaCttttggcatctatggcctat	11	8	1	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr1:248112496C>A	uc001idt.1	+	1	337	c.337C>A	c.(337-339)CTT>ATT	p.L113I	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			AGAAGCACTACTTTTGGCATC	0.443													A	248112496	A	A	248112496	3	1	53	1	0	0	0	0	1	0	0	0	11009	565	20	5	339	5	OR2L8	1	248112496	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	95379767	248112496	1138125	5	3332											
EHD3	30845	broad.mit.edu	37	chr2	31483602	31483602	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atgtggtccttggggaagatCgtgaacaccccagaggtgat	14	8	0	4			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr2:31483602C>T	uc002rnu.2	+	4	1337	c.729C>T	c.(727-729)ATC>ATT	p.I243I	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	243					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					TGGGGAAGATCGTGAACACCC	0.592													T	31483602	T	T	31483602	2	4	53	1	0	0	0	0	0	0	0	1	4979	874	31	2		2	EHD3	2	31483602	Silent	SNP	C	TCGA-06-0645-01A-01D-1492-08		31483602	211715771	6	3333											
SLC35F5	80255	broad.mit.edu	37	chr2	114489225	114489225	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	accagtacaacgcctccaatGctatgagaataacagtcatt	6	11	1	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr2:114489225G>T	uc002tku.1	-	10	1345	c.921C>A	c.(919-921)AGC>AGA	p.S307R	SLC35F5_uc002tkt.2_RNA	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	307	DUF6.|Helical; (Potential).				transport	integral to membrane					0						CGCCTCCAATGCTATGAGAAT	0.373													T	114489225	T	T	114489225	3	4	53	1	0	0	0	0	1	0	0	0	14592	1333	46	5	674	5	SLC35F5	2	114489225	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	83005623	114489225	128710148	7	3334											
GCA	25801	broad.mit.edu	37	chr2	163204201	163204201	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccagcatattcagacacttaTtcctcagctggtgactccgt	7	13	2	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr2:163204201T>C	uc002ucg.2	+	2	317	c.141T>C	c.(139-141)TAT>TAC	p.Y47Y	GCA_uc010zcu.1_Silent_p.Y28Y	NM_012198	NP_036330	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	47					cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity				0						CAGACACTTATTCCTCAGCTG	0.443													C	163204201	C	C	163204201	2	2	53	1	0	0	0	0	0	0	0	1	6283	1500	52	4		4	GCA	2	163204201	Silent	SNP	T	TCGA-06-0645-01A-01D-1492-08	48714976	163204201	79995172	8	3335											
ITGA4	3676	broad.mit.edu	37	chr2	182374515	182374515	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcttcagcagaagaaagaaaAagacataatgaaaaaaacag	7	5	2	5			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr2:182374515A>C	uc002unu.2	+	16	2589	c.1826A>C	c.(1825-1827)AAA>ACA	p.K609T	ITGA4_uc010frj.1_Missense_Mutation_p.K91T	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	609	SG1.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	AAGAAAGAAAAAGACATAATG	0.333													C	182374515	C	C	182374515	3	2	53	1	0	0	0	0	1	0	0	0	7878	14	1	5	1888	5	ITGA4	2	182374515	Missense_Mutation	SNP	A	TCGA-06-0645-01A-01D-1492-08	19170314	182374515	60824858	9	3336											
COL4A4	1286	broad.mit.edu	37	chr2	227924195	227924195	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaaagacccctctttcccGggggtcccaggtgaccaaat	10	14	1	3			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr2:227924195G>A	uc010zlt.1	-	28	2963	c.2309C>T	c.(2308-2310)CCG>CTG	p.P770L		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	770	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTCTTTCCCGGGGGTCCCAG	0.612													A	227924195	A	A	227924195	3	1	53	1	0	0	0	0	1	0	0	0	3693	1116	39	2	2847	2	COL4A4	2	227924195	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	45549680	227924195	15275178	10	3337											
LTF	4057	broad.mit.edu	37	chr3	46490484	46490484	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacaccacacgacccgcgcaCgccgggcagccacttcctcc	8	22	0	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr3:46490484C>T	uc003cpq.2	-	9	1120	c.1082G>A	c.(1081-1083)CGT>CAT	p.R361H	LTF_uc003fzr.2_Missense_Mutation_p.R317H|LTF_uc010hjh.2_Missense_Mutation_p.R361H|LTF_uc003cpr.2_Missense_Mutation_p.R348H	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	361					cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	GACCCGCGCACGCCGGGCAGC	0.667													T	46490484	T	T	46490484	3	4	53	1	0	0	0	0	1	0	0	0	9079	536	19	1	1086	1	LTF	3	46490484	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08		46490484	151531946	11	3338											
DHX30	22907	broad.mit.edu	37	chr3	47890010	47890010	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtccaaacatcaaggcagtgGacgaggctgtgatcttgctc	12	10	2	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr3:47890010G>A	uc003cru.2	+	16	2971	c.2545G>A	c.(2545-2547)GAC>AAC	p.D849N	DHX30_uc003crt.2_Missense_Mutation_p.D810N|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	849						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CAAGGCAGTGGACGAGGCTGT	0.527													A	47890010	A	A	47890010	3	1	53	1	0	0	0	0	1	0	0	0	4504	1174	41	3	2610	3	DHX30	3	47890010	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	1399526	47890010	150132420	12	3339											
IFRD2	7866	broad.mit.edu	37	chr3	50327467	50327467	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggtccagggcccagctgcaCgcagagcaggcctagcacag	14	14	0	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr3:50327467C>G	uc011bdp.1	-	5	760	c.631G>C	c.(631-633)GTG>CTG	p.V211L	IFRD2_uc003czb.2_Missense_Mutation_p.V313L	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	211							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		CCCAGCTGCACGCAGAGCAGG	0.637													G	50327467	G	G	50327467	3	3	53	1	0	0	0	0	1	0	0	0	7554	536	19	5	921	5	IFRD2	3	50327467	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	2437457	50327467	147694963	13	3340											
GPR15	2838	broad.mit.edu	37	chr3	98251667	98251667	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaatactttcaagttcctgGccattgtctctgggttgcgg	10	10	3	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr3:98251667G>A	uc011bgy.1	+	1	790	c.790G>A	c.(790-792)GCC>ACC	p.A264T		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	264	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		CAAGTTCCTGGCCATTGTCTC	0.453													A	98251667	A	A	98251667	3	1	53	1	0	0	0	0	1	0	0	0	6655	1203	42	3	792	3	GPR15	3	98251667	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	47924200	98251667	99770763	14	3341											
TRPC1	7220	broad.mit.edu	37	chr3	142524983	142524983	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aactgtggaaaatctaaacgAactgcgccaagatctgtcaa	8	9	3	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr3:142524983A>G	uc003evc.2	+	13	2424	c.2288A>G	c.(2287-2289)GAA>GGA	p.E763G	TRPC1_uc003evb.2_Missense_Mutation_p.E729G	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	763					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AATCTAAACGAACTGCGCCAA	0.373													G	142524983	G	G	142524983	3	3	53	1	0	0	0	0	1	0	0	0	16575	246	9	4	2232	4	TRPC1	3	142524983	Missense_Mutation	SNP	A	TCGA-06-0645-01A-01D-1492-08	44273316	142524983	55497447	15	3342											
CPZ	8532	broad.mit.edu	37	chr4	8605806	8605806	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcgtgtgctgaggcggacGgcctcccgctgcgcccacgt	16	15	0	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr4:8605806G>A	uc003glm.2	+	4	726	c.600G>A	c.(598-600)ACG>ACA	p.T200T	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Silent_p.T63T|CPZ_uc003glo.2_Silent_p.T189T|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	200				T -> M (in Ref. 4; BC006393).	proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						TGAGGCGGACGGCCTCCCGCT	0.701													A	8605806	A	A	8605806	2	1	53	1	0	0	0	0	0	0	0	1	3839	1103	39	2		2	CPZ	4	8605806	Silent	SNP	G	TCGA-06-0645-01A-01D-1492-08		8605806	182548470	16	3343											
FRAS1	80144	broad.mit.edu	37	chr4	79366682	79366682	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatgttgatgcaggtgatcGttttggccctgaaactgcca	12	8	0	4			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr4:79366682G>A	uc003hlb.2	+	42	6112	c.5672G>A	c.(5671-5673)CGT>CAT	p.R1891H	FRAS1_uc003hkw.2_Missense_Mutation_p.R1891H|FRAS1_uc010ijj.1_Missense_Mutation_p.R311H	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1890	CSPG 7.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GCAGGTGATCGTTTTGGCCCT	0.393													A	79366682	A	A	79366682	3	1	53	1	0	0	0	0	1	0	0	0	6042	1145	40	1	5838	1	FRAS1	4	79366682	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	70760876	79366682	111787594	17	3344											
ALPK1	80216	broad.mit.edu	37	chr4	113351620	113351620	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccagaatatccgtggcacgtGtttattgtcctacagtagtt	9	9	0	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr4:113351620G>T	uc003iap.3	+	11	1196	c.917G>T	c.(916-918)TGT>TTT	p.C306F	ALPK1_uc003ian.3_Missense_Mutation_p.C306F|ALPK1_uc011cfx.1_Missense_Mutation_p.C228F|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Missense_Mutation_p.C134F	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	306							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CGTGGCACGTGTTTATTGTCC	0.398													T	113351620	T	T	113351620	3	4	53	1	0	0	0	0	1	0	0	0	544	1377	48	5	951	5	ALPK1	4	113351620	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	33984938	113351620	77802656	18	3345											
PRSS48	345062	broad.mit.edu	37	chr4	152203364	152203364	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtaggtgactcaaggaaaCgtgtgaagtactacgtgtcc	12	8	1	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr4:152203364C>T	uc011cif.1	+	3	280	c.280C>T	c.(280-282)CGT>TGT	p.R94C	PRSS48_uc011cig.1_Intron	NM_183375	NP_899231	Q7RTY5	PRS48_HUMAN	epidermis-specific serine protease-like protein	94	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			large_intestine(1)	1						CTCAAGGAAACGTGTGAAGTA	0.473													T	152203364	T	T	152203364	3	4	53	1	0	0	0	0	1	0	0	0	12630	536	19	1	290	1	PRSS48	4	152203364	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	38851744	152203364	38950912	19	3346											
CDH18	1016	broad.mit.edu	37	chr5	19520782	19520782	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttacctggccaggcttagaaTtttcacatacaataatatca	5	9	2	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr5:19520782T>A	uc003jgc.2	-	9	1873	c.1496A>T	c.(1495-1497)AAT>ATT	p.N499I	CDH18_uc003jgd.2_Missense_Mutation_p.N499I|CDH18_uc011cnm.1_Missense_Mutation_p.N499I	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	499	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGGCTTAGAATTTTCACATAC	0.393													A	19520782	A	A	19520782	3	1	53	1	0	0	0	0	1	0	0	0	3103	1493	52	5	892	5	CDH18	5	19520782	Missense_Mutation	SNP	T	TCGA-06-0645-01A-01D-1492-08		19520782	161394478	20	3347											
PLCXD3	345557	broad.mit.edu	37	chr5	41382221	41382221	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctaacttcctgggcaaaaatCgctgggcacattttatttcc	7	11	0	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr5:41382221C>T	uc003jmm.1	-	2	621	c.519G>A	c.(517-519)GCG>GCA	p.A173A		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	173	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						GGGCAAAAATCGCTGGGCACA	0.428													T	41382221	T	T	41382221	2	4	53	1	0	0	0	0	0	0	0	1	12043	871	31	2		2	PLCXD3	5	41382221	Silent	SNP	C	TCGA-06-0645-01A-01D-1492-08	21861439	41382221	139533039	21	3348											
FGF18	8817	broad.mit.edu	37	chr5	170883763	170883763	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagcccttcaagtacacgaCggtgaccaagaggtcccgtc	11	13	1	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr5:170883763C>T	uc003mbk.2	+	5	1115	c.578C>T	c.(577-579)ACG>ATG	p.T193M		NM_003862	NP_003853	O76093	FGF18_HUMAN	fibroblast growth factor 18 precursor	193					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AAGTACACGACGGTGACCAAG	0.657													T	170883763	T	T	170883763	3	4	53	1	0	0	0	0	1	0	0	0	5846	536	19	1	596	1	FGF18	5	170883763	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	129501542	170883763	10031497	22	3349											
BCLAF1	9774	broad.mit.edu	37	chr6	136600997	136600997	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgtgatctagaattggagCgacccatttcttttctccta	7	9	3	2	rs148729378	byFrequency	TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr6:136600997C>T	uc003qgx.1	-	3	261	c.8G>A	c.(7-9)CGC>CAC	p.R3H	BCLAF1_uc003qgw.1_Missense_Mutation_p.R3H|BCLAF1_uc003qgy.1_Missense_Mutation_p.R3H|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R3H	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	3					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGAATTGGAGCGACCCATTTC	0.308													T	136600997	T	T	136600997	3	4	53	1	0	0	0	0	1	0	0	0	1383	768	27	1	2798	1	BCLAF1	6	136600997	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08		136600997	34514070	23	3350											
ESR1	2099	broad.mit.edu	37	chr6	152265483	152265483	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggccttgtccctgacggcCgaccagatggtcagtgcctt	12	14	1	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr6:152265483C>T	uc003qom.3	+	6	1306	c.936C>T	c.(934-936)GCC>GCT	p.A312A	ESR1_uc010kin.2_Silent_p.A312A|ESR1_uc010kio.2_Silent_p.A314A|ESR1_uc010kip.2_Silent_p.A311A|ESR1_uc003qon.3_Silent_p.A312A|ESR1_uc003qoo.3_Silent_p.A312A|ESR1_uc010kiq.2_Intron|ESR1_uc010kir.2_Intron|ESR1_uc011eet.1_Intron|ESR1_uc011eeu.1_Intron|ESR1_uc011eev.1_Intron|ESR1_uc011eew.1_Intron|ESR1_uc010kis.2_Intron|ESR1_uc011eex.1_Silent_p.A93A|ESR1_uc010kit.1_Silent_p.A49A|ESR1_uc011eey.1_Silent_p.A49A	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	312	Steroid-binding.|Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding	p.A312A(1)		central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	CCCTGACGGCCGACCAGATGG	0.547													T	152265483	T	T	152265483	2	4	53	1	0	0	0	0	0	0	0	1	5256	639	23	2		2	ESR1	6	152265483	Silent	SNP	C	TCGA-06-0645-01A-01D-1492-08	15664486	152265483	18849584	24	3351											
SYNE1	23345	broad.mit.edu	37	chr6	152461284	152461284	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gggcctggagaagctcccatCggtcaatcacacctggcaag	12	13	2	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr6:152461284C>T	uc010kiw.2	-	140	25861	c.25259G>A	c.(25258-25260)CGA>CAA	p.R8420Q	SYNE1_uc010kiv.2_Missense_Mutation_p.R2944Q|SYNE1_uc003qos.3_Missense_Mutation_p.R2944Q|SYNE1_uc003qot.3_Missense_Mutation_p.R8372Q|SYNE1_uc003qou.3_Missense_Mutation_p.R8420Q|SYNE1_uc003qop.3_Missense_Mutation_p.R605Q|SYNE1_uc011eez.1_Missense_Mutation_p.R622Q|SYNE1_uc003qoq.3_Missense_Mutation_p.R622Q|SYNE1_uc003qor.3_Missense_Mutation_p.R1343Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8420	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAGCTCCCATCGGTCAATCAC	0.458										HNSCC(10;0.0054)			T	152461284	T	T	152461284	3	4	53	1	0	0	0	0	1	0	0	0	15442	884	31	2	1162	2	SYNE1	6	152461284	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	195801	152461284	18653783	25	3352											
ADAM22	53616	broad.mit.edu	37	chr7	87795154	87795154	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttggatctcaggtttgcaGtaatgagctgaagtgtgtgt	13	4	1	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr7:87795154G>A	uc003ujn.2	+	24	2163	c.2084G>A	c.(2083-2085)AGT>AAT	p.S695N	ADAM22_uc003ujk.1_Missense_Mutation_p.S695N|ADAM22_uc003ujl.1_Missense_Mutation_p.S695N|ADAM22_uc003ujm.2_Missense_Mutation_p.S695N|ADAM22_uc003ujo.2_Missense_Mutation_p.S695N|ADAM22_uc003ujp.1_Missense_Mutation_p.S747N	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	695	EGF-like.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CAGGTTTGCAGTAATGAGCTG	0.368													A	87795154	A	A	87795154	3	1	53	1	0	0	0	0	1	0	0	0	244	1029	36	3	2178	3	ADAM22	7	87795154	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08		87795154	71343509	26	3353											
ZNF3	7551	broad.mit.edu	37	chr7	99672770	99672770	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctccttacccagtgagaacaCattcccgtaattctccagca	5	15	1	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr7:99672770C>G	uc003usq.2	-	5	566	c.259G>C	c.(259-261)GTG>CTG	p.V87L	ZNF3_uc003usp.2_Missense_Mutation_p.V87L|ZNF3_uc003usr.2_Missense_Mutation_p.V87L|ZNF3_uc010lgj.2_Missense_Mutation_p.V51L|ZNF3_uc003uss.2_Missense_Mutation_p.V94L|ZNF3_uc003ust.3_Missense_Mutation_p.V87L	NM_032924	NP_116313	P17036	ZNF3_HUMAN	zinc finger protein 3 isoform 2	87	KRAB.				cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			AGTGAGAACACATTCCCGTAA	0.458													G	99672770	G	G	99672770	3	3	53	1	0	0	0	0	1	0	0	0	17826	478	17	5	1218	5	ZNF3	7	99672770	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	11877616	99672770	59465893	27	3354											
MUC17	140453	broad.mit.edu	37	chr7	100674888	100674888	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtatcttaaacaggttctgCggcaaacaccgccacaggta	9	11	2	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr7:100674888C>T	uc003uxp.1	+	3	244	c.191C>T	c.(190-192)GCG>GTG	p.A64V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	64	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAGGTTCTGCGGCAAACACC	0.418													T	100674888	T	T	100674888	3	4	53	1	0	0	0	0	1	0	0	0	9974	768	27	1	201	1	MUC17	7	100674888	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	1002118	100674888	58463775	28	3355											
CCDC136	64753	broad.mit.edu	37	chr7	128434467	128434469	+	In_Frame_Del	DEL	GAA	-	-													aagaggaggaagaagaggtgGaagaagaagaagaacaagtg							TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr7:128434467_128434469delGAA	uc003vnv.1	+	2	449_451	c.82_84delGAA	c.(82-84)GAAdel	p.E32del	CCDC136_uc003vnu.1_In_Frame_Del_p.E82del|CCDC136_uc003vnw.1_In_Frame_Del_p.E32del	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	32	Glu-rich.					integral to membrane	protein binding			ovary(2)	2						agaagaggtggaagaagaagaag	0.414													-	128434469	-	-	128434467	7	5	53	1	0	1	0	1	0	0	0	0	2770	1175	41	0	88	0	CCDC136	7	128434467	In_Frame_Del	DEL	GAA	TCGA-06-0645-01A-01D-1492-08	27759579	128434467	30704196	29	3356											
TAS2R41	259287	broad.mit.edu	37	chr7	143174982	143174982	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaatgcaagcagcactgaCggccttcttcgtgttgctct	10	12	2	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr7:143174982C>T	uc003wdc.1	+	1	17	c.17C>T	c.(16-18)ACG>ATG	p.T6M	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	6	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					GCAGCACTGACGGCCTTCTTC	0.572													T	143174982	T	T	143174982	3	4	53	1	0	0	0	0	1	0	0	0	15576	536	19	1	19	1	TAS2R41	7	143174982	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	14740515	143174982	15963681	30	3357											
TAS2R41	259287	broad.mit.edu	37	chr7	143175836	143175836	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcttcagcaacctcaagcttCgaagcgtgttctcgcagctc	8	14	4	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr7:143175836C>T	uc003wdc.1	+	1	871	c.871C>T	c.(871-873)CGA>TGA	p.R291*	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	291	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					CCTCAAGCTTCGAAGCGTGTT	0.502													T	143175836	T	T	143175836	4	4	53	1	0	0	0	0	0	1	0	0	15576	876	31	2	873	2	TAS2R41	7	143175836	Nonsense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	854	143175836	15962827	31	3358											
KCNB2	9312	broad.mit.edu	37	chr8	73849053	73849053	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgccgacgataatcacctgtCgccaagccggtggaagtggg	14	12	1	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr8:73849053C>T	uc003xzb.2	+	3	2051	c.1463C>T	c.(1462-1464)TCG>TTG	p.S488L		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	488	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AATCACCTGTCGCCAAGCCGG	0.527													T	73849053	T	T	73849053	3	4	53	1	0	0	0	0	1	0	0	0	8013	893	31	2	1469	2	KCNB2	8	73849053	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08		73849053	72514969	32	3359											
KIAA1429	25962	broad.mit.edu	37	chr8	95547143	95547143	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtggtggtggagagtcTctgtcatgacttatcactct	14	7	4	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr8:95547143T>C	uc003ygo.1	-	5	421	c.408A>G	c.(406-408)AGA>AGG	p.R136R	KIAA1429_uc003ygp.2_Silent_p.R136R	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	136					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			gtggAGAGTCTCTGTCATGAC	0.343													C	95547143	C	C	95547143	2	2	53	1	0	0	0	0	0	0	0	1	8231	1548	54	4		4	KIAA1429	8	95547143	Silent	SNP	T	TCGA-06-0645-01A-01D-1492-08	21698090	95547143	50816879	33	3360											
PKHD1L1	93035	broad.mit.edu	37	chr8	110476724	110476724	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aaagtaccagtcttctgaatGatgatgtgaccccggctgca	10	10	2	4			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr8:110476724G>A	uc003yne.2	+	49	7767	c.7663G>A	c.(7663-7665)GAT>AAT	p.D2555N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2555	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCTTCTGAATGATGATGTGAC	0.443										HNSCC(38;0.096)			A	110476724	A	A	110476724	3	1	53	1	0	0	0	0	1	0	0	0	11972	1290	45	3	7857	3	PKHD1L1	8	110476724	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	14929581	110476724	35887298	34	3361											
SLC45A4	57210	broad.mit.edu	37	chr8	142229845	142229845	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcccctcggtggcatcggCgctgaagtccaggaccacca	14	15	0	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr8:142229845C>T	uc003ywd.1	-	3	669	c.361G>A	c.(361-363)GCC>ACC	p.A121T	SLC45A4_uc003ywc.1_Missense_Mutation_p.A121T|SLC45A4_uc010meq.1_Missense_Mutation_p.A119T	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	172	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GTGGCATCGGCGCTGAAGTCC	0.657													T	142229845	T	T	142229845	3	4	53	1	0	0	0	0	1	0	0	0	14643	768	27	1	2059	1	SLC45A4	8	142229845	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	31753121	142229845	4134177	35	3362											
CYLC2	1539	broad.mit.edu	37	chr9	105767804	105767804	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagtctaagaaggacgccacGaaagatgccaagaaagttgc	12	8	1	3			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr9:105767804G>A	uc004bbs.2	+	5	961	c.891G>A	c.(889-891)ACG>ACA	p.T297T		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	297	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				aggacgccacgaaagatgcca	0.164													A	105767804	A	A	105767804	2	1	53	1	0	0	0	0	0	0	0	1	4142	1045	37	2		2	CYLC2	9	105767804	Silent	SNP	G	TCGA-06-0645-01A-01D-1492-08		105767804	35445627	36	3363											
SMC3	9126	broad.mit.edu	37	chr10	112328741	112328741	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acagagatcaaacaattgtaGatcccttcagttcaaaacat	5	9	3	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr10:112328741G>C	uc001kze.2	+	2	187	c.61G>C	c.(61-63)GAT>CAT	p.D21H		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	21					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		AACAATTGTAGATCCCTTCAG	0.308													C	112328741	C	C	112328741	3	2	53	1	0	0	0	0	1	0	0	0	14784	942	33	5	67	5	SMC3	10	112328741	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08		112328741	23206006	37	3364											
SMC3	9126	broad.mit.edu	37	chr10	112341821	112341821	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tggaatataccatttacaatCaggaacttaacgagactcgt	7	8	1	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr10:112341821C>G	uc001kze.2	+	9	814	c.688C>G	c.(688-690)CAG>GAG	p.Q230E		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	230	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		CATTTACAATCAGGAACTTAA	0.343													G	112341821	G	G	112341821	3	3	53	1	0	0	0	0	1	0	0	0	14784	827	29	5	722	5	SMC3	10	112341821	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	13080	112341821	23192926	38	3365											
NHLRC2	374354	broad.mit.edu	37	chr10	115668096	115668096	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatatagagaacatttccaGtcaaccaacaatttcactac	4	10	2	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr10:115668096G>A	uc001lax.1	+	11	2194	c.1982G>A	c.(1981-1983)AGT>AAT	p.S661N	NHLRC2_uc001lay.1_RNA	NM_198514	NP_940916	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	661					cell redox homeostasis					ovary(1)	1				Epithelial(162;0.017)|all cancers(201;0.0187)		AACATTTCCAGTCAACCAACA	0.348													A	115668096	A	A	115668096	3	1	53	1	0	0	0	0	1	0	0	0	10406	1029	36	3	2024	3	NHLRC2	10	115668096	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	3326275	115668096	19866651	39	3366											
DAGLA	747	broad.mit.edu	37	chr11	61490356	61490356	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggtgatcgagttcatctaCgccatcgtgggcatcgtctg	12	11	3	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr11:61490356C>T	uc001nsa.2	+	4	444	c.333C>T	c.(331-333)TAC>TAT	p.Y111Y		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	111	Helical; (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		AGTTCATCTACGCCATCGTGG	0.607													T	61490356	T	T	61490356	2	4	53	1	0	0	0	0	0	0	0	1	4226	547	19	1		1	DAGLA	11	61490356	Silent	SNP	C	TCGA-06-0645-01A-01D-1492-08		61490356	73516160	40	3367											
CPT1A	1374	broad.mit.edu	37	chr11	68579934	68579934	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agagtccgattgatttttgcAattattcctaacgaggggtc	10	7	0	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr11:68579934A>G	uc001oog.3	-	3	422	c.252T>C	c.(250-252)ATT>ATC	p.I84I	CPT1A_uc001oof.3_Silent_p.I84I|CPT1A_uc009ysj.2_Silent_p.I84I	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	84	Mitochondrial intermembrane (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TGATTTTTGCAATTATTCCTA	0.473													G	68579934	G	G	68579934	2	3	53	1	0	0	0	0	0	0	0	1	3831	126	5	4		4	CPT1A	11	68579934	Silent	SNP	A	TCGA-06-0645-01A-01D-1492-08	7089578	68579934	66426582	41	3368											
P2RY2	5029	broad.mit.edu	37	chr11	72945705	72945705	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgctggcctgccaggccccCgtgctctactttgtcaccac	10	17	2	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr11:72945705C>T	uc001otj.2	+	3	834	c.501C>T	c.(499-501)CCC>CCT	p.P167P	P2RY2_uc001otk.2_Silent_p.P167P|P2RY2_uc001otl.2_Silent_p.P167P	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	167	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	GCCAGGCCCCCGTGCTCTACT	0.721													T	72945705	T	T	72945705	2	4	53	1	0	0	0	0	0	0	0	1	11352	639	23	2		2	P2RY2	11	72945705	Silent	SNP	C	TCGA-06-0645-01A-01D-1492-08	4365771	72945705	62060811	42	3369											
ST14	6768	broad.mit.edu	37	chr11	130069961	130069961	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggccagggccacatctgCggtgcttccctcatctctcc	10	17	3	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr11:130069961C>T	uc001qfw.2	+	16	2116	c.1923C>T	c.(1921-1923)TGC>TGT	p.C641C		NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	641	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GCCACATCTGCGGTGCTTCCC	0.627													T	130069961	T	T	130069961	2	4	53	1	0	0	0	0	0	0	0	1	15210	776	27	1		1	ST14	11	130069961	Silent	SNP	C	TCGA-06-0645-01A-01D-1492-08	57124256	130069961	4936555	43	3370											
SLC38A2	54407	broad.mit.edu	37	chr12	46757576	46757576	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aacatagcaaaaaatgaaatCttggacacattcatcattct	4	8	4	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr12:46757576C>T	uc001rpg.2	-	12	1427	c.987G>A	c.(985-987)AAG>AAA	p.K329K	SLC38A2_uc010sli.1_Silent_p.K167K|SLC38A2_uc001rph.2_Silent_p.K229K	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	329	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		AAAATGAAATCTTGGACACAT	0.343													T	46757576	T	T	46757576	2	4	53	1	0	0	0	0	0	0	0	1	14604	912	32	3		3	SLC38A2	12	46757576	Silent	SNP	C	TCGA-06-0645-01A-01D-1492-08		46757576	87094319	44	3371											
BAZ2A	11176	broad.mit.edu	37	chr12	57005685	57005685	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctgctggggaagttacgggaGaggcttttggggatgtcact	17	6	1	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr12:57005685G>A	uc001slq.1	-	6	1681	c.1487C>T	c.(1486-1488)TCT>TTT	p.S496F	BAZ2A_uc001slp.1_Missense_Mutation_p.S494F|BAZ2A_uc009zow.1_Missense_Mutation_p.S464F	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	496					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						AGTTACGGGAGAGGCTTTTGG	0.542													A	57005685	A	A	57005685	3	1	53	1	0	0	0	0	1	0	0	0	1331	942	33	3	4326	3	BAZ2A	12	57005685	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	10248109	57005685	76846210	45	3372											
ALDH1L2	160428	broad.mit.edu	37	chr12	105455479	105455479	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ctcacccgttgaaaagtactGagaggcagggatcatttttc	10	9	2	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr12:105455479G>T	uc001tlc.2	-	8	1100	c.973C>A	c.(973-975)CAG>AAG	p.Q325K	ALDH1L2_uc009zuo.2_5'UTR|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	325					10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						GAAAAGTACTGAGAGGCAGGG	0.408													T	105455479	T	T	105455479	3	4	53	1	0	0	0	0	1	0	0	0	495	1299	45	5	1862	5	ALDH1L2	12	105455479	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	48449794	105455479	28396416	46	3373											
TRPV4	59341	broad.mit.edu	37	chr12	110230485	110230485	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatgatgctataggtccccGtcagcttcagcccacgggtg	11	13	3	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr12:110230485G>A	uc001tpj.1	-	10	1891	c.1796C>T	c.(1795-1797)ACG>ATG	p.T599M	TRPV4_uc001tpg.1_Missense_Mutation_p.T565M|TRPV4_uc001tph.1_Missense_Mutation_p.T552M|TRPV4_uc001tpi.1_Missense_Mutation_p.T492M|TRPV4_uc001tpk.1_Missense_Mutation_p.T599M|TRPV4_uc001tpl.1_Missense_Mutation_p.T539M	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	599	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						ATAGGTCCCCGTCAGCTTCAG	0.582													A	110230485	A	A	110230485	3	1	53	1	0	0	0	0	1	0	0	0	16595	1145	40	1	843	1	TRPV4	12	110230485	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	4775006	110230485	23621410	47	3374											
DNAH10	196385	broad.mit.edu	37	chr12	124330629	124330629	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaacctttggctacggctaCgagtacatgggcctgaacgg	14	10	0	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr12:124330629C>T	uc001uft.3	+	31	5413	c.5388C>T	c.(5386-5388)TAC>TAT	p.Y1796Y		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1796	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCTACGGCTACGAGTACATGG	0.587													T	124330629	T	T	124330629	2	4	53	1	0	0	0	0	0	0	0	1	4598	547	19	1		1	DNAH10	12	124330629	Silent	SNP	C	TCGA-06-0645-01A-01D-1492-08	14100144	124330629	9521266	48	3375											
NYNRIN	57523	broad.mit.edu	37	chr14	24878300	24878300	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagaaagcccagctggtagaCcagatggggggctgggagga	18	8	0	3			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr14:24878300C>A	uc001wpf.3	+	4	1618	c.1300C>A	c.(1300-1302)CCA>ACA	p.P434T		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	434					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						AGCTGGTAGACCAGATGGGGG	0.552													A	24878300	A	A	24878300	3	1	53	1	0	0	0	0	1	0	0	0	10796	507	18	5	1310	5	NYNRIN	14	24878300	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08		24878300	82471240	49	3376											
PLEK2	26499	broad.mit.edu	37	chr14	67864439	67864439	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cagccatccaggaggatccgGcccttgggaggggtcactct	14	13	2	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr14:67864439G>T	uc001xjh.1	-	2	199	c.147C>A	c.(145-147)GGC>GGA	p.G49G		NM_016445	NP_057529	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	49	PH 1.				actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				ovary(1)|pancreas(1)	2				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		GGAGGATCCGGCCCTTGGGAG	0.592													T	67864439	T	T	67864439	2	4	53	1	0	0	0	0	0	0	0	1	12054	1190	42	5		5	PLEK2	14	67864439	Silent	SNP	G	TCGA-06-0645-01A-01D-1492-08	42986139	67864439	39485101	50	3377											
SGK269	79834	broad.mit.edu	37	chr15	77473255	77473255	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctggtgatgtggagtcagaTgacaccatgctctgaatgct	12	8	3	4			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr15:77473255T>C	uc002bcm.2	-	3	1322	c.1014A>G	c.(1012-1014)TCA>TCG	p.S338S	SGK269_uc002bcn.2_Silent_p.S338S	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	338	Ser-rich.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TGGAGTCAGATGACACCATGC	0.423													C	77473255	C	C	77473255	2	2	53	1	0	0	0	0	0	0	0	1	14211	1451	51	4		4	SGK269	15	77473255	Silent	SNP	T	TCGA-06-0645-01A-01D-1492-08		77473255	25058137	51	3378											
CHRNB4	1143	broad.mit.edu	37	chr15	78921872	78921872	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtcatcttctcgccgcagtCggatggcaggtagaagacga	13	10	3	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr15:78921872C>T	uc002bed.1	-	5	887	c.775G>A	c.(775-777)GAC>AAC	p.D259N	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Missense_Mutation_p.D77N	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	259	Cytoplasmic (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						TCGCCGCAGTCGGATGGCAGG	0.557													T	78921872	T	T	78921872	3	4	53	1	0	0	0	0	1	0	0	0	3393	884	31	2	729	2	CHRNB4	15	78921872	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	1448617	78921872	23609520	52	3379											
RASGRF1	5923	broad.mit.edu	37	chr15	79292172	79292172	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctatggcaaaggcagaggCggccgacaaggcactgcggt	16	10	0	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr15:79292172C>T	uc002beq.2	-	18	3082	c.2707G>A	c.(2707-2709)GCC>ACC	p.A903T	RASGRF1_uc002bep.2_Missense_Mutation_p.A887T|RASGRF1_uc010blm.1_Missense_Mutation_p.A812T|RASGRF1_uc002ber.3_Missense_Mutation_p.A887T|RASGRF1_uc010unh.1_Missense_Mutation_p.A298T|RASGRF1_uc002beo.2_Missense_Mutation_p.A119T	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	905					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						AAGGCAGAGGCGGCCGACAAG	0.562													T	79292172	T	T	79292172	3	4	53	1	0	0	0	0	1	0	0	0	13072	768	27	1	1158	1	RASGRF1	15	79292172	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	370300	79292172	23239220	53	3380											
NTRK3	4916	broad.mit.edu	37	chr15	88576210	88576210	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagtgacgagggcgtggtgAtgccgtggttgatgtggtgc	19	7	0	3			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr15:88576210A>G	uc002bme.1	-	13	1625	c.1463T>C	c.(1462-1464)ATC>ACC	p.I488T	NTRK3_uc002bmh.2_Missense_Mutation_p.I480T|NTRK3_uc002bmf.1_Missense_Mutation_p.I488T|NTRK3_uc010upl.1_Missense_Mutation_p.I390T|NTRK3_uc010bnh.1_Missense_Mutation_p.I480T|NTRK3_uc002bmg.2_Missense_Mutation_p.I488T|NTRK3_uc010bni.2_RNA	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	488	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.I488I(1)|p.I488T(1)	ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGCGTGGTGATGCCGTGGTT	0.607			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			G	88576210	G	G	88576210	3	3	53	1	0	0	0	0	1	0	0	0	10708	333	12	4	1346	4	NTRK3	15	88576210	Missense_Mutation	SNP	A	TCGA-06-0645-01A-01D-1492-08	9284038	88576210	13955182	54	3381											
SEPT12	124404	broad.mit.edu	37	chr16	4834042	4834042	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtactgctcgtattgctcGttgatgtagcccaggatggg	14	8	0	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr16:4834042G>A	uc002cxq.2	-	5	543	c.402C>T	c.(400-402)AAC>AAT	p.N134N	SEPT12_uc002cxr.2_Intron|SEPT12_uc010bty.2_RNA	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	134					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						CGTATTGCTCGTTGATGTAGC	0.627													A	4834042	A	A	4834042	2	1	53	1	0	0	0	0	0	0	0	1	14062	1136	40	1		1	SEPT12	16	4834042	Silent	SNP	G	TCGA-06-0645-01A-01D-1492-08		4834042	85520711	55	3382											
IQCK	124152	broad.mit.edu	37	chr16	19729642	19729642	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgcggccatggcggcaccgcGgcaaatccccagccacatag	12	17	0	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr16:19729642G>C	uc002dgr.2	+	2	713	c.14G>C	c.(13-15)CGG>CCG	p.R5P	IQCK_uc002dgs.2_RNA|IQCK_uc010vat.1_Missense_Mutation_p.R5P|IQCK_uc010bwc.2_RNA|IQCK_uc010vau.1_5'UTR|C16orf88_uc002dgq.2_5'Flank	NM_153208	NP_694940	Q8N0W5	IQCK_HUMAN	IQ motif containing K	5										skin(1)	1						GCGGCACCGCGGCAAATCCCC	0.692													C	19729642	C	C	19729642	3	2	53	1	0	0	0	0	1	0	0	0	7813	1116	39	5	16	5	IQCK	16	19729642	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	14895600	19729642	70625111	56	3383											
ODF4	146852	broad.mit.edu	37	chr17	8243550	8243550	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaacaggtccttgggccagCgccagaactctccgctgccc	11	16	1	1	rs147153349		TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr17:8243550C>T	uc002gle.1	+	1	363	c.181C>T	c.(181-183)CGC>TGC	p.R61C		NM_153007	NP_694552	Q2M2E3	ODFP4_HUMAN	outer dense fiber of sperm tails 4	61					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)	1						CTTGGGCCAGCGCCAGAACTC	0.592													T	8243550	T	T	8243550	3	4	53	1	0	0	0	0	1	0	0	0	10833	768	27	1	183	1	ODF4	17	8243550	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08		8243550	72951660	57	3384											
RHBDL3	162494	broad.mit.edu	37	chr17	30632431	30632431	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggaggggtgtatgctctcGtctctgcccatctggccaac	12	13	3	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr17:30632431G>A	uc002hhe.1	+	7	867	c.853G>A	c.(853-855)GTC>ATC	p.V285I	RHBDL3_uc010csw.1_Missense_Mutation_p.V277I|RHBDL3_uc010csx.1_Intron|RHBDL3_uc010csy.1_Missense_Mutation_p.V187I|RHBDL3_uc002hhf.1_Missense_Mutation_p.V187I	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	285	Helical; (Potential).				proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				GTATGCTCTCGTCTCTGCCCA	0.542													A	30632431	A	A	30632431	3	1	53	1	0	0	0	0	1	0	0	0	13323	1145	40	1	879	1	RHBDL3	17	30632431	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	22388881	30632431	50562779	58	3385											
POLRMT	5442	broad.mit.edu	37	chr19	622950	622950	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agcgcccggcacagtgctttCtcccattggtcccgcagggt	12	15	1	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr19:622950C>A	uc002lpf.1	-	7	1382	c.1326G>T	c.(1324-1326)GAG>GAT	p.E442D		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	442					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGTGCTTTCTCCCATTGGT	0.672													A	622950	A	A	622950	3	1	53	1	0	0	0	0	1	0	0	0	12238	912	32	5	2426	5	POLRMT	19	622950	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08		622950	58506033	59	3386											
PODNL1	79883	broad.mit.edu	37	chr19	14046600	14046600	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttggttggcagccagatccGcgacacggagggaccggggc	17	12	0	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr19:14046600G>A	uc002mxr.2	-	5	723	c.449C>T	c.(448-450)GCG>GTG	p.A150V	PODNL1_uc010xni.1_Missense_Mutation_p.A68V|PODNL1_uc010xnj.1_Missense_Mutation_p.A148V|PODNL1_uc002mxs.2_Intron	NM_024825	NP_079101	Q6PEZ8	PONL1_HUMAN	podocan-like 1 isoform 1	150	Leu-rich.|LRR 4.					proteinaceous extracellular matrix				central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(19;5.26e-23)			AGCCAGATCCGCGACACGGAG	0.667													A	14046600	A	A	14046600	3	1	53	1	0	0	0	0	1	0	0	0	12179	1087	38	1	1105	1	PODNL1	19	14046600	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	13423650	14046600	45082383	60	3387											
EMR2	30817	broad.mit.edu	37	chr19	14857101	14857101	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggagagtctgtttttcaaaAtccagagagtcaccagaaag	10	7	3	3			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr19:14857101A>C	uc002mzp.1	-	18	2582	c.2126T>G	c.(2125-2127)ATT>AGT	p.I709S	EMR2_uc010dzs.1_Missense_Mutation_p.I168S|EMR2_uc010xnw.1_Missense_Mutation_p.I651S|EMR2_uc002mzo.1_Missense_Mutation_p.I698S|EMR2_uc002mzq.1_Missense_Mutation_p.I649S|EMR2_uc002mzr.1_Missense_Mutation_p.I660S|EMR2_uc002mzs.1_Missense_Mutation_p.I567S|EMR2_uc002mzt.1_Missense_Mutation_p.I605S|EMR2_uc002mzu.1_Missense_Mutation_p.I616S|EMR2_uc010xnx.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	709	Cytoplasmic (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GTTTTTCAAAATCCAGAGAGT	0.388													C	14857101	C	C	14857101	3	2	53	1	0	0	0	0	1	0	0	0	5105	101	4	5	361	5	EMR2	19	14857101	Missense_Mutation	SNP	A	TCGA-06-0645-01A-01D-1492-08	810501	14857101	44271882	61	3388											
CPAMD8	27151	broad.mit.edu	37	chr19	17086872	17086872	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acactcttatcaactgcggcGacgcacacacagctgcccct	7	17	2	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr19:17086872G>A	uc002nfb.2	-	16	2021	c.1989C>T	c.(1987-1989)GTC>GTT	p.V663V		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	616						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CAACTGCGGCGACGCACACAC	0.597													A	17086872	A	A	17086872	2	1	53	1	0	0	0	0	0	0	0	1	3795	1045	37	2		2	CPAMD8	19	17086872	Silent	SNP	G	TCGA-06-0645-01A-01D-1492-08	2229771	17086872	42042111	62	3389											
ZFP30	22835	broad.mit.edu	37	chr19	38126468	38126468	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacactccttacattcatagGgtttttctccagtatgaagt	6	10	2	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr19:38126468G>A	uc002ogv.1	-	6	1490	c.974C>T	c.(973-975)CCC>CTC	p.P325L	ZFP30_uc002ogw.1_Missense_Mutation_p.P325L|ZFP30_uc002ogx.1_Missense_Mutation_p.P325L|ZFP30_uc010xtt.1_Missense_Mutation_p.P324L	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACATTCATAGGGTTTTTCTCC	0.438													A	38126468	A	A	38126468	3	1	53	1	0	0	0	0	1	0	0	0	17641	1232	43	3	589	3	ZFP30	19	38126468	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	21039596	38126468	21002515	63	3390											
MAP4K1	11184	broad.mit.edu	37	chr19	39086283	39086283	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgtccctgcacagacccaCggcctccaccgcttcggtca	8	21	1	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr19:39086283C>T	uc002oix.1	-	28	2374	c.2266G>A	c.(2266-2268)GTG>ATG	p.V756M	MAP4K1_uc002oiw.1_Missense_Mutation_p.V343M|MAP4K1_uc002oiy.1_Missense_Mutation_p.V756M	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	756	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CACAGACCCACGGCCTCCACC	0.622													T	39086283	T	T	39086283	3	4	53	1	0	0	0	0	1	0	0	0	9259	536	19	1	317	1	MAP4K1	19	39086283	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	959815	39086283	20042700	64	3391											
LILRA1	11024	broad.mit.edu	37	chr19	55107682	55107682	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtggcagacccttcatctcGgtgcatccgggccccacggt	12	16	2	1	rs138767008		TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr19:55107682G>A	uc002qgh.1	+	7	1169	c.987G>A	c.(985-987)TCG>TCA	p.S329S	LILRA2_uc010yfg.1_Silent_p.S327S|LILRA1_uc010yfh.1_Silent_p.S329S	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	329	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CCTTCATCTCGGTGCATCCGG	0.612													A	55107682	A	A	55107682	2	1	53	1	0	0	0	0	0	0	0	1	8784	1103	39	2		2	LILRA1	19	55107682	Silent	SNP	G	TCGA-06-0645-01A-01D-1492-08	16021399	55107682	4021301	65	3392											
NLRP8	126205	broad.mit.edu	37	chr19	56466478	56466478	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgaaatgtccctctctcGtaacccttccggggtttaat	8	12	1	1			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr19:56466478G>A	uc002qmh.2	+	3	1125	c.1054G>A	c.(1054-1056)GTA>ATA	p.V352I	NLRP8_uc010etg.2_Missense_Mutation_p.V352I	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	352	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TCCCTCTCTCGTAACCCTTCC	0.458													A	56466478	A	A	56466478	3	1	53	1	0	0	0	0	1	0	0	0	10483	1145	40	1	1064	1	NLRP8	19	56466478	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	1358796	56466478	2662505	66	3393											
CASS4	57091	broad.mit.edu	37	chr20	55027872	55027872	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caattggcctctggaagttcTtgtgactgacagtgtccaga	11	9	2	3			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr20:55027872T>C	uc002xxp.2	+	6	1865	c.1640T>C	c.(1639-1641)CTT>CCT	p.L547P	CASS4_uc002xxq.3_Missense_Mutation_p.L547P|CASS4_uc002xxr.2_Missense_Mutation_p.L547P|CASS4_uc010zze.1_Missense_Mutation_p.L493P|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	547					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						CTGGAAGTTCTTGTGACTGAC	0.493													C	55027872	C	C	55027872	3	2	53	1	0	0	0	0	1	0	0	0	2683	1609	56	4	1658	4	CASS4	20	55027872	Missense_Mutation	SNP	T	TCGA-06-0645-01A-01D-1492-08		55027872	7997648	67	3394											
TMPRSS15	5651	broad.mit.edu	37	chr21	19744570	19744570	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tacttctccatcacaaaataAatcagcttttatacacgtta	2	10	3	0			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr21:19744570A>T	uc002ykw.2	-	6	635	c.604T>A	c.(604-606)TTA>ATA	p.L202I		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	202	Extracellular (Potential).|LDL-receptor class A 1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TCACAAAATAAATCAGCTTTT	0.383													T	19744570	T	T	19744570	3	4	53	1	0	0	0	0	1	0	0	0	16243	11	1	5	2535	5	TMPRSS15	21	19744570	Missense_Mutation	SNP	A	TCGA-06-0645-01A-01D-1492-08		19744570	28385325	68	3395											
ICOSLG	23308	broad.mit.edu	37	chr21	45655287	45655287	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccccgcatgttcaagaagaCggtgtcattctgcagagcct	11	12	3	3			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chr21:45655287C>T	uc002zee.2	-	4	699	c.565G>A	c.(565-567)GTC>ATC	p.V189I	ICOSLG_uc011afc.1_Missense_Mutation_p.V99I|ICOSLG_uc002zef.2_Missense_Mutation_p.V72I|ICOSLG_uc010gpp.1_Missense_Mutation_p.V189I	NM_015259	NP_056074	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand precursor	189	Extracellular (Potential).|Ig-like C2-type.				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding				0				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		TTCAAGAAGACGGTGTCATTC	0.552													T	45655287	T	T	45655287	3	4	53	1	0	0	0	0	1	0	0	0	7487	536	19	1	359	1	ICOSLG	21	45655287	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	25910717	45655287	2474608	69	3396											
MAGEB6	158809	broad.mit.edu	37	chrX	26212572	26212572	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagaaggcgtgcacgttggcGcaattcctgcagaagaagtt	13	8	0	3			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chrX:26212572G>A	uc004dbr.2	+	2	758	c.609G>A	c.(607-609)GCG>GCA	p.A203A	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	203	MAGE.									ovary(3)	3						GCACGTTGGCGCAATTCCTGC	0.478													A	26212572	A	A	26212572	2	1	53	1	0	0	0	0	0	0	0	1	9179	1074	38	1		1	MAGEB6	23	26212572	Silent	SNP	G	TCGA-06-0645-01A-01D-1492-08		26212572	129057988	70	3397											
FAM70A	55026	broad.mit.edu	37	chrX	119410833	119410833	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gcagaccagagcaggtggtaGaggtggatgatatcttggca	16	6	1	4			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chrX:119410833G>A	uc004eso.3	-	8	881	c.654C>T	c.(652-654)CTC>CTT	p.L218L	FAM70A_uc004esp.3_Silent_p.L194L|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	218						integral to membrane				lung(1)|breast(1)	2						GCAGGTGGTAGAGGTGGATGA	0.542													A	119410833	A	A	119410833	2	1	53	1	0	0	0	0	0	0	0	1	5605	929	33	3		3	FAM70A	23	119410833	Silent	SNP	G	TCGA-06-0645-01A-01D-1492-08	93198261	119410833	35859727	71	3398											
SAGE1	55511	broad.mit.edu	37	chrX	134986679	134986679	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgaagagaggataaataaCggccaaccagtagctgataa	11	6	0	3			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chrX:134986679C>T	uc004ezh.2	+	4	431	c.264C>T	c.(262-264)AAC>AAT	p.N88N	SAGE1_uc010nry.1_Intron|SAGE1_uc011mvv.1_Silent_p.N88N	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	88										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GGATAAATAACGGCCAACCAG	0.443													T	134986679	T	T	134986679	2	4	53	1	0	0	0	0	0	0	0	1	13809	535	19	1		1	SAGE1	23	134986679	Silent	SNP	C	TCGA-06-0645-01A-01D-1492-08	15575846	134986679	20283881	72	3399											
GPR112	139378	broad.mit.edu	37	chrX	135430793	135430793	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttccaggatcacacctaCgacctttctctctccaacag	4	17	3	0	rs146283448		TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chrX:135430793C>T	uc004ezu.1	+	6	5219	c.4928C>T	c.(4927-4929)ACG>ATG	p.T1643M	GPR112_uc010nsb.1_Missense_Mutation_p.T1438M|GPR112_uc010nsc.1_Missense_Mutation_p.T1410M	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1643	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ATCACACCTACGACCTTTCTC	0.468													T	135430793	T	T	135430793	3	4	53	1	0	0	0	0	1	0	0	0	6629	536	19	1	4938	1	GPR112	23	135430793	Missense_Mutation	SNP	C	TCGA-06-0645-01A-01D-1492-08	444114	135430793	19839767	73	3400											
DNASE1L1	1774	broad.mit.edu	37	chrX	153633852	153633852	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggcattgaaggcgcagatgcGaaaggcctgggccccattgg	16	10	0	2			TCGA-06-0645-01A-01D-1492-08	TCGA-06-0645-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	3f458a3c-baac-427d-b3d6-6f15104a8886	c917b2bc-abdd-480f-b6fe-b442abfd1b43	g.chrX:153633852G>A	uc004fks.1	-	2	249	c.58C>T	c.(58-60)CGC>TGC	p.R20C	DNASE1L1_uc004fkt.1_Missense_Mutation_p.R20C|DNASE1L1_uc004fku.1_Missense_Mutation_p.R20C|DNASE1L1_uc004fkv.1_Missense_Mutation_p.R20C|DNASE1L1_uc004fkw.1_Missense_Mutation_p.R20C	NM_006730	NP_006721	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1 precursor	20					DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCGCAGATGCGAAAGGCCTGG	0.607													A	153633852	A	A	153633852	3	1	53	1	0	0	0	0	1	0	0	0	4661	1058	37	2	878	2	DNASE1L1	23	153633852	Missense_Mutation	SNP	G	TCGA-06-0645-01A-01D-1492-08	18203059	153633852	1636708	74	3401											
LCK	3932	broad.mit.edu	37	chr1	32740011	32740011	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gagaactgccattatcccatAgtcccactggatggcaaggg	11	11	0	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr1:32740011A>T	uc001bux.2	+	2	219	c.81A>T	c.(79-81)ATA>ATT	p.I27I	LCK_uc001buy.2_Silent_p.I27I|LCK_uc001buz.2_Silent_p.I27I|LCK_uc010ohc.1_Silent_p.I71I|LCK_uc001bva.2_Silent_p.I27I	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	27	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	ATTATCCCATAGTCCCACTGG	0.547			T	TRB@	T-ALL								T	32740011	T	T	32740011	2	4	54	1	0	0	0	0	0	0	0	1	8676	410	15	5		5	LCK	1	32740011	Silent	SNP	A	TCGA-06-0646-01A-01D-1492-08		32740011	216510610	1	3402											
AKR1A1	10327	broad.mit.edu	37	chr1	46027470	46027470	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgtttcagggggcaatgGcggcttcctgtgttctactg	14	9	2	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr1:46027470G>A	uc001cod.2	+	3	468	c.4G>A	c.(4-6)GCG>ACG	p.A2T	AKR1A1_uc009vxw.2_Missense_Mutation_p.A2T|AKR1A1_uc001coe.2_Missense_Mutation_p.A2T	NM_006066	NP_006057	P14550	AK1A1_HUMAN	aldo-keto reductase family 1, member A1	2					glucose metabolic process		alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					GGGGGCAATGGCGGCTTCCTG	0.507													A	46027470	A	A	46027470	3	1	54	1	0	0	0	0	1	0	0	0	465	1203	42	3	6	3	AKR1A1	1	46027470	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	13287459	46027470	203223151	2	3403											
CCDC17	149483	broad.mit.edu	37	chr1	46086575	46086575	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccctgcgcaccacactcacCtgaggaatcccattcagctg	7	17	2	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr1:46086575C>T	uc010olt.1	-	11	1747	c.1599G>A	c.(1597-1599)CAG>CAA	p.Q533Q	CCDC17_uc009vxy.2_Silent_p.Q501Q|CCDC17_uc010ols.1_Silent_p.Q524Q|CCDC17_uc001com.3_Silent_p.Q354Q|CCDC17_uc001con.3_RNA|CCDC17_uc009vxz.2_Intron	NM_001114938	NP_001108410	Q96LX7	CCD17_HUMAN	coiled-coil domain containing 17	533										ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CCACACTCACCTGAGGAATCC	0.592													T	46086575	T	T	46086575	2	4	54	1	0	0	0	0	0	0	0	1	2793	695	24	3		3	CCDC17	1	46086575	Silent	SNP	C	TCGA-06-0646-01A-01D-1492-08	59105	46086575	203164046	3	3404											
CDKN2C	1031	broad.mit.edu	37	chr1	51436083	51436083	+	Frame_Shift_Del	DEL	A	-	-													agttggcgtccgcagctgccAggggggacctagagcaactt							TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr1:51436083delA	uc001csf.2	+	2	1259	c.43delA	c.(43-45)AGGfs	p.R15fs	CDKN2C_uc001csg.2_Frame_Shift_Del_p.R15fs	NM_001262	NP_001253	P42773	CDN2C_HUMAN	cyclin-dependent kinase inhibitor 2C	15	ANK 1.				cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0?(4)|p.R15fs*4(1)		central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(5)|ovary(2)|thyroid(1)|lung(1)|kidney(1)	17				GBM - Glioblastoma multiforme(3;3.61e-13)|all cancers(3;0.00151)		CGCAGCTGCCAGGGGGGACCT	0.468			D		glioma|MM				Multiple_Endocrine_Neoplasia_type_1				-	51436083	-	-	51436083	7	5	54	1	0	1	0	1	0	0	0	0	3165	179	7	0	45	0	CDKN2C	1	51436083	Frame_Shift_Del	DEL	A	TCGA-06-0646-01A-01D-1492-08	5349508	51436083	197814538	4	3405											
FCRL4	83417	broad.mit.edu	37	chr1	157556156	157556156	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtatcccctgtgccttcagCcacggagcagacaaggacca	11	14	1	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr1:157556156C>T	uc001fqw.2	-	6	1073	c.937G>A	c.(937-939)GCT>ACT	p.A313T	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	313	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GTGCCTTCAGCCACGGAGCAG	0.597													T	157556156	T	T	157556156	3	4	54	1	0	0	0	0	1	0	0	0	5797	739	26	3	638	3	FCRL4	1	157556156	Missense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08	106120073	157556156	91694465	5	3406											
FCRL2	79368	broad.mit.edu	37	chr1	157718679	157718679	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	actcaccattgacatacactGgctgcagctcctccatgtct	6	15	2	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr1:157718679G>T	uc001fre.2	-	9	1438	c.1379C>A	c.(1378-1380)CCA>CAA	p.P460Q	FCRL2_uc001frd.2_Missense_Mutation_p.P207Q|FCRL2_uc010phz.1_Intron|FCRL2_uc009wsp.2_Missense_Mutation_p.P176Q	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	460	Cytoplasmic (Potential).|ITIM motif 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GACATACACTGGCTGCAGCTC	0.502													T	157718679	T	T	157718679	3	4	54	1	0	0	0	0	1	0	0	0	5795	1348	47	5	163	5	FCRL2	1	157718679	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	162523	157718679	91531942	6	3407											
CEP350	9857	broad.mit.edu	37	chr1	179965731	179965731	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atttcagttccagccatctgGaatcaaagcacgtatactgt	7	10	3	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr1:179965731G>A	uc001gnt.2	+	6	822	c.439G>A	c.(439-441)GAA>AAA	p.E147K	CEP350_uc001gnr.1_Missense_Mutation_p.E121K|CEP350_uc009wxl.2_Missense_Mutation_p.E146K|CEP350_uc001gnu.2_5'UTR	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	147						centrosome|nucleus|spindle				ovary(4)	4						CAGCCATCTGGAATCAAAGCA	0.343													A	179965731	A	A	179965731	3	1	54	1	0	0	0	0	1	0	0	0	3254	1175	41	3	457	3	CEP350	1	179965731	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	22247052	179965731	69284890	7	3408											
RYR2	6262	broad.mit.edu	37	chr1	237802446	237802446	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaagaagccatcaaaatcGccgaggatccttcccgagat	10	11	1	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr1:237802446G>A	uc001hyl.1	+	46	7180	c.7060G>A	c.(7060-7062)GCC>ACC	p.A2354T		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2354	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CATCAAAATCGCCGAGGATCC	0.493													A	237802446	A	A	237802446	3	1	54	1	0	0	0	0	1	0	0	0	13769	1087	38	1	7242	1	RYR2	1	237802446	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	57836715	237802446	11448175	8	3409											
CCDC150	284992	broad.mit.edu	37	chr2	197540931	197540931	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgctggatgcagcccatgCcagtatcacaaatgaactac	8	11	1	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr2:197540931C>T	uc002utp.1	+	11	1337	c.1202C>T	c.(1201-1203)GCC>GTC	p.A401V	CCDC150_uc010zgq.1_RNA|CCDC150_uc010zgr.1_RNA|CCDC150_uc010zgs.1_Missense_Mutation_p.A69V	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	401	Potential.										0						GCAGCCCATGCCAGTATCACA	0.388													T	197540931	T	T	197540931	3	4	54	1	0	0	0	0	1	0	0	0	2785	739	26	3	1244	3	CCDC150	2	197540931	Missense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08		197540931	45658442	9	3410											
APPL1	26060	broad.mit.edu	37	chr3	57302493	57302493	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaagcaacagaaagaactcaAtaaacaaaaacagattgaaa	6	6	1	4	rs144769112		TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr3:57302493A>G	uc003dio.2	+	21	2108	c.1961A>G	c.(1960-1962)AAT>AGT	p.N654S	APPL1_uc011bey.1_Missense_Mutation_p.N637S|ASB14_uc003dip.1_3'UTR|ASB14_uc003diq.2_3'UTR	NM_012096	NP_036228	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH	654	PID.|Potential.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)		aaagaactcaataaacaaaaa	0.209													G	57302493	G	G	57302493	3	3	54	1	0	0	0	0	1	0	0	0	817	101	4	4	2043	4	APPL1	3	57302493	Missense_Mutation	SNP	A	TCGA-06-0646-01A-01D-1492-08		57302493	140719937	10	3411											
MAGI1	9223	broad.mit.edu	37	chr3	65342645	65342645	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatactctctgctgcctttcGgatcccttgcgtgtgcccgc	9	15	1	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr3:65342645G>A	uc003dmn.2	-	23	4323	c.3797C>T	c.(3796-3798)CCG>CTG	p.P1266L	MAGI1_uc003dmm.2_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1295					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GCTGCCTTTCGGATCCCTTGC	0.592													A	65342645	A	A	65342645	3	1	54	1	0	0	0	0	1	0	0	0	9190	1116	39	2	595	2	MAGI1	3	65342645	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	8040152	65342645	132679785	11	3412											
TMPRSS7	344805	broad.mit.edu	37	chr3	111794198	111794198	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagttcctccgcccttcaccGcatcatcggaggcacagaca	9	16	2	1	rs142998665	by1000genomes	TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr3:111794198G>A	uc010hqb.2	+	13	1606	c.1436G>A	c.(1435-1437)CGC>CAC	p.R479H	TMPRSS7_uc011bhr.1_Missense_Mutation_p.R334H	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	605	Extracellular (Potential).				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						GCCCTTCACCGCATCATCGGA	0.537													A	111794198	A	A	111794198	3	1	54	1	0	0	0	0	1	0	0	0	16249	1087	38	1	1482	1	TMPRSS7	3	111794198	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	46451553	111794198	86228232	12	3413											
ABCF3	55324	broad.mit.edu	37	chr3	183906608	183906608	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgccaaactggaggagattgAggctgacaaggcacctgcca	13	10	0	3			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr3:183906608A>G	uc003fmz.2	+	8	1029	c.896A>G	c.(895-897)GAG>GGG	p.E299G	ABCF3_uc003fna.2_Missense_Mutation_p.E293G|ABCF3_uc003fnb.2_5'UTR	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	299	ABC transporter 1.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAGGAGATTGAGGCTGACAAG	0.532													G	183906608	G	G	183906608	3	3	54	1	0	0	0	0	1	0	0	0	67	304	11	4	926	4	ABCF3	3	183906608	Missense_Mutation	SNP	A	TCGA-06-0646-01A-01D-1492-08	72112410	183906608	14115822	13	3414											
SORCS2	57537	broad.mit.edu	37	chr4	7719828	7719828	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgccccctcacgccgccccGgggcctgcaggtcagcattc	12	19	2	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr4:7719828G>A	uc003gkb.3	+	18	2342	c.2342G>A	c.(2341-2343)CGG>CAG	p.R781Q	SORCS2_uc011bwi.1_Missense_Mutation_p.R609Q	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	781	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						ACGCCGCCCCGGGGCCTGCAG	0.652													A	7719828	A	A	7719828	3	1	54	1	0	0	0	0	1	0	0	0	14931	1116	39	2	2412	2	SORCS2	4	7719828	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08		7719828	183434448	14	3415											
CLOCK	9575	broad.mit.edu	37	chr4	56348941	56348941	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcattttactacagcttacGgtaaacaacataacatacta	3	10	1	0	rs149959118		TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr4:56348941G>A	uc003haz.1	-	5	938	c.12C>T	c.(10-12)ACC>ACT	p.T4T	CLOCK_uc003hba.1_Silent_p.T4T	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	4					circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			TACAGCTTACGGTAAACAACA	0.269													A	56348941	A	A	56348941	2	1	54	1	0	0	0	0	0	0	0	1	3549	1103	39	2		2	CLOCK	4	56348941	Silent	SNP	G	TCGA-06-0646-01A-01D-1492-08	48629113	56348941	134805335	15	3416											
USP38	84640	broad.mit.edu	37	chr4	144141519	144141519	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgttcatttcggcccaatggAtttgatgacaacgacccacc	8	12	1	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr4:144141519A>T	uc003ijb.2	+	10	3573	c.3039A>T	c.(3037-3039)GGA>GGT	p.G1013G	USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	1013					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					GGCCCAATGGATTTGATGACA	0.458													T	144141519	T	T	144141519	2	4	54	1	0	0	0	0	0	0	0	1	17066	320	12	5		5	USP38	4	144141519	Silent	SNP	A	TCGA-06-0646-01A-01D-1492-08	87792578	144141519	47012757	16	3417											
PCDHB6	56130	broad.mit.edu	37	chr5	140532029	140532029	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cggtgcccgagggtccctttCcagggcatctggtggatgtg	16	11	1	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr5:140532029C>G	uc003lir.2	+	1	2191	c.2191C>G	c.(2191-2193)CCA>GCA	p.P731A	PCDHB6_uc011dah.1_Missense_Mutation_p.P595A	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	731	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGTCCCTTTCCAGGGCATCT	0.612													G	140532029	G	G	140532029	3	3	54	1	0	0	0	0	1	0	0	0	11546	855	30	5	2193	5	PCDHB6	5	140532029	Missense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08		140532029	40383231	17	3418											
FILIP1	27145	broad.mit.edu	37	chr6	76063397	76063397	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctgctctagcatgcgccGgtaggtttctttctgttttt	10	10	3	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr6:76063397G>A	uc003pia.2	-	4	860	c.487C>T	c.(487-489)CGG>TGG	p.R163W	FILIP1_uc003phy.1_Missense_Mutation_p.R163W|FILIP1_uc003phz.2_Missense_Mutation_p.R64W|FILIP1_uc010kbe.2_Missense_Mutation_p.R166W	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	163										skin(3)|ovary(1)	4						AGCATGCGCCGGTAGGTTTCT	0.428													A	76063397	A	A	76063397	3	1	54	1	0	0	0	0	1	0	0	0	5894	1115	39	2	3166	2	FILIP1	6	76063397	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08		76063397	95051670	18	3419											
SGK1	6446	broad.mit.edu	37	chr6	134493370	134493370	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtggatgttgtgctgttgtgTtcaatgttctccttgcagag	13	6	2	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr6:134493370T>C	uc003qen.3	-	8	836	c.747A>G	c.(745-747)GAA>GAG	p.E249E	SGK1_uc003qeo.3_Silent_p.E344E|SGK1_uc011ect.1_Silent_p.E239E|SGK1_uc011ecu.1_Silent_p.E205E|SGK1_uc011ecv.1_Silent_p.E263E|SGK1_uc011ecw.1_Silent_p.E277E	NM_005627	NP_005618	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1 isoform	249	Protein kinase.				apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(3)|stomach(1)|lung(1)|central_nervous_system(1)	6	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		TGCTGTTGTGTTCAATGTTCT	0.468													C	134493370	C	C	134493370	2	2	54	1	0	0	0	0	0	0	0	1	14207	1722	60	4		4	SGK1	6	134493370	Silent	SNP	T	TCGA-06-0646-01A-01D-1492-08	58429973	134493370	36621697	19	3420											
LRP11	84918	broad.mit.edu	37	chr6	150174287	150174287	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccttgctaagtggaggcGcatccttttctgagaaagaa	11	9	1	2	rs150922217	byFrequency	TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr6:150174287G>A	uc003qng.2	-	2	947	c.623C>T	c.(622-624)GCG>GTG	p.A208V	LRP11_uc003qnh.1_Missense_Mutation_p.A208V	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	208	Extracellular (Potential).					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		AAGTGGAGGCGCATCCTTTTC	0.438													A	150174287	A	A	150174287	3	1	54	1	0	0	0	0	1	0	0	0	8953	1087	38	1	903	1	LRP11	6	150174287	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	15680917	150174287	20940780	20	3421											
SEMA3C	10512	broad.mit.edu	37	chr7	80433493	80433493	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcagtcagtttttctttgaAgaagaagtacaccttagcat	8	7	3	3			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr7:80433493A>G	uc003uhj.2	-	8	1292	c.730T>C	c.(730-732)TTC>CTC	p.F244L	SEMA3C_uc011kgw.1_Missense_Mutation_p.F262L|SEMA3C_uc011kgx.1_Missense_Mutation_p.F96L	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	244	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						TTTTCTTTGAAGAAGAAGTAC	0.368													G	80433493	G	G	80433493	3	3	54	1	0	0	0	0	1	0	0	0	14026	72	3	4	1569	4	SEMA3C	7	80433493	Missense_Mutation	SNP	A	TCGA-06-0646-01A-01D-1492-08		80433493	78705170	21	3422											
COL1A2	1278	broad.mit.edu	37	chr7	94037543	94037543	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgtgttggtgcccctggcCcagctgtaagtgcttccatt	12	12	0	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr7:94037543C>T	uc003ung.1	+	14	1159	c.688C>T	c.(688-690)CCA>TCA	p.P230S	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	230					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging	p.P230S(1)	COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGCCCCTGGCCCAGCTGTAAG	0.398										HNSCC(75;0.22)			T	94037543	T	T	94037543	3	4	54	1	0	0	0	0	1	0	0	0	3678	623	22	3	742	3	COL1A2	7	94037543	Missense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08	13604050	94037543	65101120	22	3423											
TRRAP	8295	broad.mit.edu	37	chr7	98552870	98552870	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggaagatcattgtggaggaGgggcacaccgtcccgcagct	15	11	1	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr7:98552870G>A	uc003upp.2	+	40	6068	c.5859G>A	c.(5857-5859)GAG>GAA	p.E1953E	TRRAP_uc011kis.1_Silent_p.E1935E|TRRAP_uc003upr.2_Silent_p.E1652E	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1953					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity	p.E1935E(1)		ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTGTGGAGGAGGGGCACACCG	0.642													A	98552870	A	A	98552870	2	1	54	1	0	0	0	0	0	0	0	1	16598	991	35	3		3	TRRAP	7	98552870	Silent	SNP	G	TCGA-06-0646-01A-01D-1492-08	4515327	98552870	60585793	23	3424											
RELN	5649	broad.mit.edu	37	chr7	103191709	103191709	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attccagtctcactggatccGcggatgagctatcagtcgaa	10	11	2	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr7:103191709G>A	uc003vca.2	-	41	6267	c.6107C>T	c.(6106-6108)GCG>GTG	p.A2036V	RELN_uc010liz.2_Missense_Mutation_p.A2036V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2036					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CACTGGATCCGCGGATGAGCT	0.502													A	103191709	A	A	103191709	3	1	54	1	0	0	0	0	1	0	0	0	13220	1087	38	1	4375	1	RELN	7	103191709	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	4638839	103191709	55946954	24	3425											
KEL	3792	broad.mit.edu	37	chr7	142639989	142639989	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgatggctagccccccaacGtctgcagcattctctaagaa	9	14	2	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr7:142639989G>A	uc003wcb.2	-	17	2124	c.1914C>T	c.(1912-1914)GAC>GAT	p.D638D		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	638	Extracellular (Potential).	Proton donor (By similarity).			proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GCCCCCCAACGTCTGCAGCAT	0.502													A	142639989	A	A	142639989	2	1	54	1	0	0	0	0	0	0	0	1	8142	1136	40	1		1	KEL	7	142639989	Silent	SNP	G	TCGA-06-0646-01A-01D-1492-08	39448280	142639989	16498674	25	3426											
COL22A1	169044	broad.mit.edu	37	chr8	139606337	139606337	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcccccatggggccggccCggcctggaagcccatctttt	12	17	1	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr8:139606337C>T	uc003yvd.2	-	63	4985	c.4538G>A	c.(4537-4539)CGG>CAG	p.R1513Q	COL22A1_uc011ljo.1_Missense_Mutation_p.R793Q	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1513	Pro-rich.|Gly-rich.|Collagen-like 15.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.R1513Q(1)		ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGGGCCGGCCCGGCCTGGAAG	0.662										HNSCC(7;0.00092)			T	139606337	T	T	139606337	3	4	54	1	0	0	0	0	1	0	0	0	3681	652	23	2	354	2	COL22A1	8	139606337	Missense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08		139606337	6757685	26	3427											
ZNF322B	387328	broad.mit.edu	37	chr9	99960660	99960660	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcactcacattacagacaaaCggtttttcaccaatgcgtac	5	12	3	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr9:99960660C>T	uc004axd.1	-	1	1251	c.1134G>A	c.(1132-1134)CCG>CCA	p.P378P	uc004axb.2_5'Flank|ZNF322B_uc004axc.1_5'Flank|uc010msl.1_Intron	NM_199005	NP_945356			zinc finger protein 322B												0		Acute lymphoblastic leukemia(62;0.158)				TACAGACAAACGGTTTTTCAC	0.443													T	99960660	T	T	99960660	2	4	54	1	0	0	0	0	0	0	0	1	17839	523	19	1		1	ZNF322B	9	99960660	Silent	SNP	C	TCGA-06-0646-01A-01D-1492-08		99960660	41252771	27	3428											
C5	727	broad.mit.edu	37	chr9	123745005	123745005	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aattgataattctcaactagCcacaataaagaattacaaat	3	7	1	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr9:123745005C>T	uc004bkv.2	-	26	3348	c.3318G>A	c.(3316-3318)TGG>TGA	p.W1106*		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1106					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCTCAACTAGCCACAATAAAG	0.299													T	123745005	T	T	123745005	4	4	54	1	0	0	0	0	0	1	0	0	2280	740	26	3	1776	3	C5	9	123745005	Nonsense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08	23784345	123745005	17468426	28	3429											
PAOX	196743	broad.mit.edu	37	chr10	135203245	135203245	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccctgcagacggcgccggCgcccaggtatgtggcgtgcc	15	16	0	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr10:135203245C>T	uc001lmv.2	+	6	1466	c.1386C>T	c.(1384-1386)GGC>GGT	p.G462G	PAOX_uc001lmw.2_Intron|PAOX_uc001lmx.2_Intron|PAOX_uc001lmy.2_Intron|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_RNA|PAOX_uc001lnc.2_RNA	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	600					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		ACGGCGCCGGCGCCCAGGTAT	0.741													T	135203245	T	T	135203245	2	4	54	1	0	0	0	0	0	0	0	1	11423	755	27	1		1	PAOX	10	135203245	Silent	SNP	C	TCGA-06-0646-01A-01D-1492-08		135203245	331502	29	3430											
POU2AF1	5450	broad.mit.edu	37	chr11	111225126	111225126	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaggactggctctgggatagAgatggggagctggacaaact	16	6	1	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr11:111225126A>G	uc001plg.3	-	5	886	c.631T>C	c.(631-633)TCT>CCT	p.S211P		NM_006235	NP_006226	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	211					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			kidney(1)	1		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		TCTGGGATAGAGATGGGGAGC	0.622			T	BCL6	NHL								G	111225126	G	G	111225126	3	3	54	1	0	0	0	0	1	0	0	0	12270	304	11	4	143	4	POU2AF1	11	111225126	Missense_Mutation	SNP	A	TCGA-06-0646-01A-01D-1492-08		111225126	23781390	30	3431											
HYOU1	10525	broad.mit.edu	37	chr11	118919049	118919049	+	Frame_Shift_Del	DEL	A	-	-													ctcacgctgctcctctgtggAcacttcctggtactcgggct							TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr11:118919049delA	uc001puu.2	-	20	2480	c.2287delT	c.(2287-2289)TCCfs	p.S763fs	HYOU1_uc001put.2_Frame_Shift_Del_p.S728fs|HYOU1_uc010ryu.1_Frame_Shift_Del_p.S721fs|HYOU1_uc010ryv.1_Frame_Shift_Del_p.S652fs|HYOU1_uc001pux.3_Frame_Shift_Del_p.S763fs	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	763						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		TCCTCTGTGGACACTTCCTGG	0.617													-	118919049	-	-	118919049	7	5	54	1	0	1	0	1	0	0	0	0	7470	275	10	0	740	0	HYOU1	11	118919049	Frame_Shift_Del	DEL	A	TCGA-06-0646-01A-01D-1492-08	7693923	118919049	16087467	31	3432											
CHEK1	1111	broad.mit.edu	37	chr11	125505406	125505406	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acatacctcaacccttggaaAaaaatcgattctgctcctct	4	13	3	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr11:125505406A>T	uc009zbo.2	+	7	1588	c.696A>T	c.(694-696)AAA>AAT	p.K232N	CHEK1_uc010sbh.1_Missense_Mutation_p.K248N|CHEK1_uc010sbi.1_Missense_Mutation_p.K232N|CHEK1_uc001qcf.3_Missense_Mutation_p.K232N|CHEK1_uc009zbp.2_Missense_Mutation_p.K232N|CHEK1_uc001qcg.3_Missense_Mutation_p.K232N|CHEK1_uc009zbq.2_Missense_Mutation_p.K232N|CHEK1_uc001qci.1_RNA	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	232	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		ACCCTTGGAAAAAAATCGATT	0.373								Other_conserved_DNA_damage_response_genes					T	125505406	T	T	125505406	3	4	54	1	0	0	0	0	1	0	0	0	3334	11	1	5	718	5	CHEK1	11	125505406	Missense_Mutation	SNP	A	TCGA-06-0646-01A-01D-1492-08	6586357	125505406	9501110	32	3433											
ETNK1	55500	broad.mit.edu	37	chr12	22778163	22778163	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctccgagagcgggccgggctCagttcagctgctgtccagac	14	14	2	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr12:22778163C>G	uc001rft.2	+	1	88	c.66C>G	c.(64-66)CTC>CTG	p.L22L	ETNK1_uc009ziz.2_Silent_p.L22L|ETNK1_uc001rfs.2_Silent_p.L22L	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	22					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						GGGCCGGGCTCAGTTCAGCTG	0.726													G	22778163	G	G	22778163	2	3	54	1	0	0	0	0	0	0	0	1	5273	813	29	5		5	ETNK1	12	22778163	Silent	SNP	C	TCGA-06-0646-01A-01D-1492-08		22778163	111073732	33	3434											
TMTC1	83857	broad.mit.edu	37	chr12	29757135	29757135	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatgtaaaggactctctccGccaccacaaaacccaccctg	6	17	1	0	rs144467040		TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr12:29757135G>A	uc001rjb.2	-	7	1376	c.902C>T	c.(901-903)GCG>GTG	p.A301V	TMTC1_uc001riz.2_Missense_Mutation_p.A58V|TMTC1_uc001rja.2_Missense_Mutation_p.A145V|TMTC1_uc001rjc.1_Missense_Mutation_p.A363V	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	409	Helical; (Potential).					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GACTCTCTCCGCCACCACAAA	0.507													A	29757135	A	A	29757135	3	1	54	1	0	0	0	0	1	0	0	0	16257	1087	38	1	1470	1	TMTC1	12	29757135	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	6978972	29757135	104094760	34	3435											
MAPK1IP1L	93487	broad.mit.edu	37	chr14	55529424	55529424	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acctcctcaaggctggccagGctccaacccttggaataatc	8	15	1	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr14:55529424G>T	uc001xbq.1	+	3	271	c.107G>T	c.(106-108)GGC>GTC	p.G36V		NM_144578	NP_653179	Q8NDC0	MISSL_HUMAN	MAPK-interacting and spindle-stabilizing	36	Pro-rich.										0						GGCTGGCCAGGCTCCAACCCT	0.537													T	55529424	T	T	55529424	3	4	54	1	0	0	0	0	1	0	0	0	9278	1203	42	5	113	5	MAPK1IP1L	14	55529424	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08		55529424	51820116	35	3436											
ZNF174	7727	broad.mit.edu	37	chr16	3458844	3458844	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggagagaagccataccaGtgtggccagtgtgggaaaag	15	7	0	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr16:3458844G>A	uc002cvc.2	+	3	1964	c.1149G>A	c.(1147-1149)CAG>CAA	p.Q383Q		NM_003450	NP_003441	Q15697	ZN174_HUMAN	zinc finger protein 174 isoform a	383	C2H2-type 3.				negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0						AGCCATACCAGTGTGGCCAGT	0.542													A	3458844	A	A	3458844	2	1	54	1	0	0	0	0	0	0	0	1	17741	1020	36	3		3	ZNF174	16	3458844	Silent	SNP	G	TCGA-06-0646-01A-01D-1492-08		3458844	86895909	36	3437											
FUS	2521	broad.mit.edu	37	chr16	31202308	31202308	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taactacggggatgatcgtcGtggtggcagaggaggctatg	17	6	0	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr16:31202308G>A	uc002ebf.2	+	14	1501	c.1418G>A	c.(1417-1419)CGT>CAT	p.R473H	FUS_uc002ebh.2_Missense_Mutation_p.R472H|FUS_uc002ebg.2_Missense_Mutation_p.R268H|FUS_uc002ebi.2_Missense_Mutation_p.R474H|FUS_uc002ebj.2_Missense_Mutation_p.R269H	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	473	Arg/Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		GATGATCGTCGTGGTGGCAGA	0.602			T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								A	31202308	A	A	31202308	3	1	54	1	0	0	0	0	1	0	0	0	6100	1145	40	1	1472	1	FUS	16	31202308	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	27743464	31202308	59152445	37	3438											
PDPR	55066	broad.mit.edu	37	chr16	70190589	70190589	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcgccacgtttgcctgggctTtgtgcacaatttttctgagg	12	10	1	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr16:70190589T>G	uc002eyf.1	+	19	3404	c.2447T>G	c.(2446-2448)TTT>TGT	p.F816C	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.F716C|PDPR_uc002eyg.1_Missense_Mutation_p.F483C|PDPR_uc002eyh.2_Missense_Mutation_p.F161C|PDPR_uc010vls.1_Missense_Mutation_p.F161C	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	816					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		TGCCTGGGCTTTGTGCACAAT	0.552													G	70190589	G	G	70190589	3	3	54	1	0	0	0	0	1	0	0	0	11689	1841	64	5	2513	5	PDPR	16	70190589	Missense_Mutation	SNP	T	TCGA-06-0646-01A-01D-1492-08	38988281	70190589	20164164	38	3439											
MON1B	22879	broad.mit.edu	37	chr16	77229553	77229553	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcgcctcatttaccacgtgGctgagaaggagacactactg	11	11	1	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr16:77229553G>A	uc002fez.2	+	5	1747	c.1417G>A	c.(1417-1419)GCT>ACT	p.A473T	MON1B_uc010vnf.1_Missense_Mutation_p.A364T|MON1B_uc010vng.1_Missense_Mutation_p.A327T|MON1B_uc002ffa.2_Missense_Mutation_p.A353T	NM_014940	NP_055755	Q7L1V2	MON1B_HUMAN	MON1 homolog B	473							protein binding				0						TTACCACGTGGCTGAGAAGGA	0.587													A	77229553	A	A	77229553	3	1	54	1	0	0	0	0	1	0	0	0	9699	1203	42	3	1431	3	MON1B	16	77229553	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	7038964	77229553	13125200	39	3440											
LRRC50	123872	broad.mit.edu	37	chr16	84183927	84183927	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taccccagcattgaatgataCgctgtatttacactttaaag	6	9	0	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr16:84183927C>T	uc002fhl.3	+	3	513	c.332C>T	c.(331-333)ACG>ATG	p.T111M	LRRC50_uc010chi.1_RNA	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	111	LRR 1.		Missing (in CILD13).		axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						TTGAATGATACGCTGTATTTA	0.378									Kartagener_syndrome				T	84183927	T	T	84183927	3	4	54	1	0	0	0	0	1	0	0	0	9009	536	19	1	342	1	LRRC50	16	84183927	Missense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08	6954374	84183927	6170826	40	3441											
USP6	9098	broad.mit.edu	37	chr17	5042663	5042663	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccaccagcccagttccagCggcccatttgctcagcttcc	8	19	1	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr17:5042663C>T	uc002gau.1	+	22	3422	c.1192C>T	c.(1192-1194)CGG>TGG	p.R398W	USP6_uc002gav.1_Missense_Mutation_p.R398W|USP6_uc010ckz.1_Missense_Mutation_p.R81W|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	398					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						CCAGTTCCAGCGGCCCATTTG	0.657			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								T	5042663	T	T	5042663	3	4	54	1	0	0	0	0	1	0	0	0	17083	759	27	1	1242	1	USP6	17	5042663	Missense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08		5042663	76152547	41	3442											
MKS1	54903	broad.mit.edu	37	chr17	56288050	56288050	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caattctacaaagaagtggaCgtagagattgtcatactcat	8	7	3	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr17:56288050C>T	uc002ivr.1	-	11	1069	c.994G>A	c.(994-996)GTC>ATC	p.V332I	MKS1_uc010wnq.1_Missense_Mutation_p.V129I|MKS1_uc002ivs.1_Missense_Mutation_p.V332I	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	332	B9.				cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						AAGAAGTGGACGTAGAGATTG	0.398													T	56288050	T	T	56288050	3	4	54	1	0	0	0	0	1	0	0	0	9609	536	19	1	717	1	MKS1	17	56288050	Missense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08	51245387	56288050	24907160	42	3443											
LLGL2	3993	broad.mit.edu	37	chr17	73555474	73555474	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaggaccggaccatcagctcGgacgcggtgctgcagcggtg	17	12	1	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr17:73555474G>C	uc002joh.2	+	6	667	c.513G>C	c.(511-513)TCG>TCC	p.S171S	LLGL2_uc002jog.1_Silent_p.S171S|LLGL2_uc010dgf.1_Silent_p.S171S|LLGL2_uc002joi.2_Silent_p.S171S|LLGL2_uc010dgg.1_Silent_p.S171S|LLGL2_uc002joj.2_Silent_p.S160S	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	171					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CCATCAGCTCGGACGCGGTGC	0.617													C	73555474	C	C	73555474	2	2	54	1	0	0	0	0	0	0	0	1	8834	1103	39	5		5	LLGL2	17	73555474	Silent	SNP	G	TCGA-06-0646-01A-01D-1492-08	17267424	73555474	7639736	43	3444											
RNF213	57674	broad.mit.edu	37	chr17	78355436	78355436	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gacctggagcagttggccaaGatgctgggacacagtgccga	15	10	0	1			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr17:78355436G>A	uc002jyh.1	+	32	8329	c.8106G>A	c.(8104-8106)AAG>AAA	p.K2702K	uc002jyi.1_Intron|RNF213_uc010dhw.1_Silent_p.K1084K	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGTTGGCCAAGATGCTGGGAC	0.567													A	78355436	A	A	78355436	2	1	54	1	0	0	0	0	0	0	0	1	13477	933	33	3		3	RNF213	17	78355436	Silent	SNP	G	TCGA-06-0646-01A-01D-1492-08	4799962	78355436	2839774	44	3445											
DSC3	1825	broad.mit.edu	37	chr18	28584256	28584256	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgttgcagcttggccggcCctgtcttttacagtaatagg	11	9	1	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr18:28584256C>T	uc002kwj.3	-	13	2120	c.1965G>A	c.(1963-1965)AGG>AGA	p.R655R	DSC3_uc002kwi.3_Silent_p.R655R	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	655	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CTTGGCCGGCCCTGTCTTTTA	0.383													T	28584256	T	T	28584256	2	4	54	1	0	0	0	0	0	0	0	1	4767	622	22	3		3	DSC3	18	28584256	Silent	SNP	C	TCGA-06-0646-01A-01D-1492-08		28584256	49492992	45	3446											
MUC16	94025	broad.mit.edu	37	chr19	9090417	9090417	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgagatggacttctgatcttGctgtcaagagttgtaaaacc	10	7	3	3			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr19:9090417G>C	uc002mkp.2	-	1	1602	c.1398C>G	c.(1396-1398)AGC>AGG	p.S466R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	466	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCTGATCTTGCTGTCAAGAG	0.522													C	9090417	C	C	9090417	3	2	54	1	0	0	0	0	1	0	0	0	9973	1310	46	5	42461	5	MUC16	19	9090417	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08		9090417	50038566	46	3447											
ZNF571	51276	broad.mit.edu	37	chr19	38056190	38056193	+	Frame_Shift_Del	DEL	GTAA	-	-													cctgaatgaactctcaggtgGtaagtaagttgtgagccacg							TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr19:38056190_38056193delGTAA	uc002ogt.2	-	4	1238_1241	c.1137_1140delTTAC	c.(1135-1140)ACTTACfs	p.T379fs	uc002ogm.2_Intron|uc002ogn.2_Intron|ZNF540_uc002ogo.2_Intron|ZNF540_uc002ogp.2_Intron|ZNF540_uc002ogq.2_Intron|ZNF571_uc002ogr.1_Intron|uc002ogs.1_5'Flank|ZNF571_uc010efp.2_Frame_Shift_Del_p.T379fs	NM_016536	NP_057620	Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	379_380	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTCTCAGGTGGTAAGTAAGTTGTG	0.377													-	38056193	-	-	38056190	7	5	54	1	0	1	0	1	0	0	0	0	18000	1256	44	0	693	0	ZNF571	19	38056190	Frame_Shift_Del	DEL	GTAA	TCGA-06-0646-01A-01D-1492-08	28965773	38056190	21072793	47	3448											
REM1	28954	broad.mit.edu	37	chr20	30072181	30072181	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacagcccgcagcgcacgccGccgggcactcaaggcccgct	13	19	1	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr20:30072181G>A	uc002wwa.2	+	5	1129	c.845G>A	c.(844-846)CGC>CAC	p.R282H	NCRNA00028_uc010ztn.1_5'Flank	NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	282	Arg-rich.|Calmodulin-binding (By similarity).				small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			AGCGCACGCCGCCGGGCACTC	0.701													A	30072181	A	A	30072181	3	1	54	1	0	0	0	0	1	0	0	0	13222	1087	38	1	859	1	REM1	20	30072181	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08		30072181	32953339	48	3449											
HCK	3055	broad.mit.edu	37	chr20	30689234	30689234	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgctgctggaaaaaccgtcCggaggagcggccgaccttcg	15	13	0	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr20:30689234C>T	uc002wxh.2	+	13	1664	c.1493C>T	c.(1492-1494)CCG>CTG	p.P498L	HCK_uc010gdy.2_Missense_Mutation_p.P477L|HCK_uc002wxi.2_Missense_Mutation_p.P476L	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	498	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.P477L(1)		lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AAAAACCGTCCGGAGGAGCGG	0.572													T	30689234	T	T	30689234	3	4	54	1	0	0	0	0	1	0	0	0	6994	652	23	2	1549	2	HCK	20	30689234	Missense_Mutation	SNP	C	TCGA-06-0646-01A-01D-1492-08	617053	30689234	32336286	49	3450											
ELMO2	63916	broad.mit.edu	37	chr20	45023078	45023078	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagctgggcgttagcacctGgccactcaatggccactttg	13	12	1	0			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chr20:45023078G>A	uc002xrt.1	-	3	254	c.44C>T	c.(43-45)CCA>CTA	p.P15L	ELMO2_uc002xru.1_Missense_Mutation_p.P15L|ELMO2_uc010zxr.1_Missense_Mutation_p.P15L|ELMO2_uc010zxs.1_5'UTR|ELMO2_uc002xrx.1_Missense_Mutation_p.P15L	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	15					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GTTAGCACCTGGCCACTCAAT	0.547													A	45023078	A	A	45023078	3	1	54	1	0	0	0	0	1	0	0	0	5066	1348	47	3	2198	3	ELMO2	20	45023078	Missense_Mutation	SNP	G	TCGA-06-0646-01A-01D-1492-08	14333844	45023078	18002442	50	3451											
ACRC	93953	broad.mit.edu	37	chrX	70823913	70823913	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgacagcagtgatgattcGgaagctcccgacgacagcag	13	11	0	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chrX:70823913G>A	uc004eae.2	+	8	1287	c.786G>A	c.(784-786)TCG>TCA	p.S262S	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	262	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					GTGATGATTCGGAAGCTCCCG	0.552													A	70823913	A	A	70823913	2	1	54	1	0	0	0	0	0	0	0	1	171	1103	39	2		2	ACRC	23	70823913	Silent	SNP	G	TCGA-06-0646-01A-01D-1492-08		70823913	84446647	51	3452			1	9		2	2	31	G		5.039162e-05
ACRC	93953	broad.mit.edu	37	chrX	70823943	70823943	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgacagcagtgatgattcGgaagctcccgacgacagcag	13	11	0	2			TCGA-06-0646-01A-01D-1492-08	TCGA-06-0646-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	89742b5d-0256-48c7-8d8f-41b6e5e5b561	3d9ff278-deb8-47a5-b14d-7be8db09d4d7	g.chrX:70823943G>A	uc004eae.2	+	8	1317	c.816G>A	c.(814-816)TCG>TCA	p.S272S	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	272	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					GTGATGATTCGGAAGCTCCCG	0.557													A	70823943	A	A	70823943	2	1	54	1	0	0	0	0	0	0	0	1	171	1103	39	2		2	ACRC	23	70823943	Silent	SNP	G	TCGA-06-0646-01A-01D-1492-08	30	70823943	84446617	52	3453			1	9		2	2	31	G		5.039162e-05
DBT	1629	broad.mit.edu	37	chr1	100706430	100706430	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taccacatgtttgaaaatagCgaacacaaatctacagatga	6	8	1	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr1:100706430C>T	uc001dta.2	-	2	95	c.62G>A	c.(61-63)CGC>CAC	p.R21H	DBT_uc010oug.1_5'UTR	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	21					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TTGAAAATAGCGAACACAAAT	0.313													T	100706430	T	T	100706430	3	4	55	1	0	0	0	0	1	0	0	0	4258	768	27	1	1426	1	DBT	1	100706430	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08		100706430	148544191	1	3454											
ANP32E	81611	broad.mit.edu	37	chr1	150202934	150202934	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctactgtactgagatcttttAttttgtttccactcagattg	6	8	2	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr1:150202934A>G	uc001etw.2	-	3	669	c.299T>C	c.(298-300)ATA>ACA	p.I100T	ANP32E_uc010pbu.1_Missense_Mutation_p.I52T|ANP32E_uc010pbv.1_Intron|ANP32E_uc001etv.3_Missense_Mutation_p.I100T|ANP32E_uc010pbw.1_Missense_Mutation_p.I100T	NM_030920	NP_112182	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	100	LRR 4.					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGATCTTTTATTTTGTTTCC	0.363													G	150202934	G	G	150202934	3	3	55	1	0	0	0	0	1	0	0	0	709	449	16	4	527	4	ANP32E	1	150202934	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08	49496504	150202934	99047687	2	3455											
HMCN1	83872	broad.mit.edu	37	chr1	186084452	186084452	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tagtaaatgttcaaactactCtggcttgtgaggctactggg	11	7	2	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr1:186084452C>T	uc001grq.1	+	75	11696	c.11467C>T	c.(11467-11469)CTG>TTG	p.L3823L		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3823	Ig-like C2-type 37.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TCAAACTACTCTGGCTTGTGA	0.398													T	186084452	T	T	186084452	2	4	55	1	0	0	0	0	0	0	0	1	7220	912	32	3		3	HMCN1	1	186084452	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08	35881518	186084452	63166169	3	3456											
SMYD2	56950	broad.mit.edu	37	chr1	214505455	214505455	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tacatgttgcacatgatgtaCcaggccatgggtgtctgctt	11	9	1	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr1:214505455C>A	uc010ptx.1	+	10	1065	c.1032C>A	c.(1030-1032)TAC>TAA	p.Y344*	SMYD2_uc009xdj.2_3'UTR|SMYD2_uc010ptw.1_RNA|SMYD2_uc009xdl.1_Intron	NM_020197	NP_064582	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	344					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		ACATGATGTACCAGGCCATGG	0.517											OREG0012979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	214505455	A	A	214505455	4	1	55	1	0	0	0	0	0	1	0	0	14822	518	18	5	1070	5	SMYD2	1	214505455	Nonsense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	28421003	214505455	34745166	4	3457											
CCDC88A	55704	broad.mit.edu	37	chr2	55561635	55561635	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgctggatttttttattgctGttctctaaagttttttgcag	8	5	1	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr2:55561635G>C	uc002ryv.2	-	15	3164	c.2322C>G	c.(2320-2322)AAC>AAG	p.N774K	CCDC88A_uc010yoz.1_Missense_Mutation_p.N774K|CCDC88A_uc010ypa.1_Missense_Mutation_p.N774K|CCDC88A_uc010ypb.1_Missense_Mutation_p.N676K|CCDC88A_uc002ryu.2_Missense_Mutation_p.N57K|CCDC88A_uc002ryw.2_Missense_Mutation_p.N57K	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	774	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TTTTATTGCTGTTCTCTAAAG	0.338													C	55561635	C	C	55561635	3	2	55	1	0	0	0	0	1	0	0	0	2863	1368	48	5	3365	5	CCDC88A	2	55561635	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08		55561635	187637738	5	3458											
RMND5A	64795	broad.mit.edu	37	chr2	86992995	86992995	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tttttagacattcaggttttGatgggaagccttgtgtacct	10	6	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr2:86992995G>A	uc010ytm.1	+	6	1079	c.702G>A	c.(700-702)TTG>TTA	p.L234L	RMND5A_uc002srs.3_Intron|RMND5A_uc002srr.2_Silent_p.L234L	NM_022780	NP_073617	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog	234										ovary(1)|skin(1)	2						TTCAGGTTTTGATGGGAAGCC	0.428													A	86992995	A	A	86992995	2	1	55	1	0	0	0	0	0	0	0	1	13397	1281	45	3		3	RMND5A	2	86992995	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08	31431360	86992995	156206378	6	3459											
DDX18	8886	broad.mit.edu	37	chr2	118587005	118587005	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aatttgcctcaggttgctctGtcatttggtttcaaggtgcc	10	9	4	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr2:118587005G>T	uc002tlh.1	+	13	1932	c.1833G>T	c.(1831-1833)CTG>CTT	p.L611L		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	611							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						AGGTTGCTCTGTCATTTGGTT	0.403													T	118587005	T	T	118587005	2	4	55	1	0	0	0	0	0	0	0	1	4345	1364	48	5		5	DDX18	2	118587005	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08	31594010	118587005	124612368	7	3460											
TTN	7273	broad.mit.edu	37	chr2	179556814	179556814	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctctggcacgggtttcttgGgaacctcaggaactttaaag	11	10	3	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr2:179556814G>T	uc010zfg.1	-	118	28183	c.27959C>A	c.(27958-27960)CCC>CAC	p.P9320H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P5981H|TTN_uc010fre.1_Missense_Mutation_p.P431H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10247							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTTTCTTGGGAACCTCAGG	0.433													T	179556814	T	T	179556814	3	4	55	1	0	0	0	0	1	0	0	0	16732	1232	43	5	72806	5	TTN	2	179556814	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	60969809	179556814	63642559	8	3461											
TTN	7273	broad.mit.edu	37	chr2	179569962	179569962	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caaatgcttgaagaagacctCggaagtcagtgattccatac	9	9	1	4			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr2:179569962C>T	uc010zfg.1	-	100	26035	c.25811G>A	c.(25810-25812)CGA>CAA	p.R8604Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R5265Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9531							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGAAGACCTCGGAAGTCAGT	0.383													T	179569962	T	T	179569962	3	4	55	1	0	0	0	0	1	0	0	0	16732	884	31	2	75026	2	TTN	2	179569962	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	13148	179569962	63629411	9	3462											
FGD5	152273	broad.mit.edu	37	chr3	14862435	14862435	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtcgacatcccacctcctttCgacctggcctgcatcaccaa	6	18	1	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr3:14862435C>T	uc003bzc.2	+	1	1967	c.1857C>T	c.(1855-1857)TTC>TTT	p.F619F	FGD5_uc011avk.1_Silent_p.F619F	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	619					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CACCTCCTTTCGACCTGGCCT	0.557													T	14862435	T	T	14862435	2	4	55	1	0	0	0	0	0	0	0	1	5836	883	31	2		2	FGD5	3	14862435	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08		14862435	183159995	10	3463											
GCET2	257144	broad.mit.edu	37	chr3	111842437	111842437	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcatgcctggggtctgtagaAggcatatgtagaagtgaata	14	5	1	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr3:111842437A>G	uc003dys.1	-	6	552	c.402T>C	c.(400-402)CCT>CCC	p.P134P	C3orf52_uc011bht.1_Intron|C3orf52_uc003dyr.1_Intron|GCET2_uc003dyt.1_Silent_p.P68P	NM_152785	NP_689998	Q8N6F7	GCET2_HUMAN	germinal center expressed transcript 2 isoform	134						mitochondrion					0						GGTCTGTAGAAGGCATATGTA	0.483													G	111842437	G	G	111842437	2	3	55	1	0	0	0	0	0	0	0	1	6288	59	3	4		4	GCET2	3	111842437	Silent	SNP	A	TCGA-06-0648-01A-01W-0323-08	96980002	111842437	86179993	11	3464											
ABCF3	55324	broad.mit.edu	37	chr3	183907351	183907351	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgacccctcagacgtggCcctccaccatcctagtcgtc	8	18	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr3:183907351C>A	uc003fmz.2	+	13	1253	c.1120C>A	c.(1120-1122)CCC>ACC	p.P374T	ABCF3_uc003fna.2_Missense_Mutation_p.P368T|ABCF3_uc003fnb.2_Missense_Mutation_p.P55T	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	374	ABC transporter 1.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCAGACGTGGCCCTCCACCAT	0.617													A	183907351	A	A	183907351	3	1	55	1	0	0	0	0	1	0	0	0	67	739	26	5	1170	5	ABCF3	3	183907351	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	72064914	183907351	14115079	12	3465											
EVC2	132884	broad.mit.edu	37	chr4	5630350	5630350	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcagaaggccctgcacacGggtctctgatgactggaggt	14	11	2	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr4:5630350G>A	uc003gij.2	-	12	1876	c.1822C>T	c.(1822-1824)CGT>TGT	p.R608C	EVC2_uc011bwb.1_Missense_Mutation_p.R48C|EVC2_uc003gik.2_Missense_Mutation_p.R528C	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	608						integral to membrane				large_intestine(3)|ovary(2)	5						CCCTGCACACGGGTCTCTGAT	0.498													A	5630350	A	A	5630350	3	1	55	1	0	0	0	0	1	0	0	0	5286	1116	39	2	2148	2	EVC2	4	5630350	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08		5630350	185523926	13	3466											
SLC2A9	56606	broad.mit.edu	37	chr4	9889261	9889261	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtaggggacccagggggcGtggtcctgggagagaacagg	21	7	0	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr4:9889261G>A	uc003gmc.2	-	10	1282	c.1221C>T	c.(1219-1221)CAC>CAT	p.H407H	SLC2A9_uc003gmd.2_Silent_p.H378H	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	407	Extracellular (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						CCCAGGGGGCGTGGTCCTGGG	0.393													A	9889261	A	A	9889261	2	1	55	1	0	0	0	0	0	0	0	1	14552	1136	40	1		1	SLC2A9	4	9889261	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08	4258911	9889261	181265015	14	3467											
PCDH7	5099	broad.mit.edu	37	chr4	30724267	30724267	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtccttaacatcaaagacgAgaacgacaacgtgccgtcca	9	12	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr4:30724267A>G	uc003gsk.1	+	1	2231	c.1223A>G	c.(1222-1224)GAG>GGG	p.E408G	PCDH7_uc011bxw.1_Missense_Mutation_p.E361G|PCDH7_uc011bxx.1_Missense_Mutation_p.E408G	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	408	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						ATCAAAGACGAGAACGACAAC	0.642													G	30724267	G	G	30724267	3	3	55	1	0	0	0	0	1	0	0	0	11516	304	11	4	1225	4	PCDH7	4	30724267	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08	20835006	30724267	160430009	15	3468											
CXCL6	6372	broad.mit.edu	37	chr4	74702791	74702791	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aggtgttccccgcaggcccgCagtgctccaaggtggaagtg	15	12	0	0	rs149811429		TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr4:74702791C>A	uc003hhf.2	+	2	415	c.220C>A	c.(220-222)CAG>AAG	p.Q74K	IL8_uc011cbh.1_Intron	NM_002993	NP_002984	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6 (granulocyte	74					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CGCAGGCCCGCAGTGCTCCAA	0.542													A	74702791	A	A	74702791	3	1	55	1	0	0	0	0	1	0	0	0	4088	711	25	5	226	5	CXCL6	4	74702791	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	43978524	74702791	116451485	16	3469											
NPNT	255743	broad.mit.edu	37	chr4	106863540	106863540	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtaccattttaaagggtgaCacaggaaataataattggat	10	4	0	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr4:106863540C>A	uc003hya.2	+	8	1045	c.840C>A	c.(838-840)GAC>GAA	p.D280E	NPNT_uc011cfc.1_Missense_Mutation_p.D297E|NPNT_uc011cfd.1_Missense_Mutation_p.D310E|NPNT_uc011cfe.1_Missense_Mutation_p.D310E|NPNT_uc010ilt.1_Missense_Mutation_p.D280E|NPNT_uc011cff.1_Missense_Mutation_p.D280E|NPNT_uc010ilu.1_Missense_Mutation_p.D176E	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	280					cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		TAAAGGGTGACACAGGAAATA	0.393													A	106863540	A	A	106863540	3	1	55	1	0	0	0	0	1	0	0	0	10590	477	17	5	1019	5	NPNT	4	106863540	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	32160749	106863540	84290736	17	3470											
TLL1	7092	broad.mit.edu	37	chr4	166960565	166960565	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactatattgaagtaagagaCgggtactggagaaaatcacc	11	6	1	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr4:166960565C>T	uc003irh.1	+	10	1880	c.1233C>T	c.(1231-1233)GAC>GAT	p.D411D	TLL1_uc011cjn.1_Silent_p.D411D|TLL1_uc011cjo.1_Silent_p.D235D	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	411	CUB 1.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AAGTAAGAGACGGGTACTGGA	0.388													T	166960565	T	T	166960565	2	4	55	1	0	0	0	0	0	0	0	1	15942	535	19	1		1	TLL1	4	166960565	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08	60097025	166960565	24193711	18	3471											
ODZ3	55714	broad.mit.edu	37	chr4	183594220	183594220	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggagaacttgatattggcCgaagagcaattcaagagatt	11	7	1	4			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr4:183594220C>T	uc003ivd.1	+	6	1211	c.1174C>T	c.(1174-1176)CGA>TGA	p.R392*		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	392	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGATATTGGCCGAAGAGCAAT	0.388													T	183594220	T	T	183594220	4	4	55	1	0	0	0	0	0	1	0	0	10836	644	23	2	1196	2	ODZ3	4	183594220	Nonsense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	16633655	183594220	7560056	19	3472											
ODZ3	55714	broad.mit.edu	37	chr4	183594343	183594343	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattgattggagtatatggcCggaaaggcttaccgccttcc	11	10	0	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr4:183594343C>T	uc003ivd.1	+	6	1334	c.1297C>T	c.(1297-1299)CGG>TGG	p.R433W		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	433	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AGTATATGGCCGGAAAGGCTT	0.388													T	183594343	T	T	183594343	3	4	55	1	0	0	0	0	1	0	0	0	10836	643	23	2	1319	2	ODZ3	4	183594343	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	123	183594343	7559933	20	3473											
FAT1	2195	broad.mit.edu	37	chr4	187557880	187557880	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggggccctcatccttgtcGgtggctatgacgtgatagag	14	9	1	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr4:187557880G>A	uc003izf.2	-	5	4019	c.3831C>T	c.(3829-3831)ACC>ACT	p.T1277T		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1277	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CATCCTTGTCGGTGGCTATGA	0.493										HNSCC(5;0.00058)			A	187557880	A	A	187557880	2	1	55	1	0	0	0	0	0	0	0	1	5689	1103	39	2		2	FAT1	4	187557880	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08	3963537	187557880	3596396	21	3474											
TTC37	9652	broad.mit.edu	37	chr5	94856458	94856458	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctttttctatgtagtctacGgcttttccatcaagataatc	6	9	3	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr5:94856458G>A	uc003klb.2	-	20	2346	c.2076C>T	c.(2074-2076)GCC>GCT	p.A692A		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	692	TPR 12.						binding			ovary(3)|pancreas(1)	4						TGTAGTCTACGGCTTTTCCAT	0.284													A	94856458	A	A	94856458	2	1	55	1	0	0	0	0	0	0	0	1	16702	1103	39	2		2	TTC37	5	94856458	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08		94856458	86058802	22	3475											
DMXL1	1657	broad.mit.edu	37	chr5	118503534	118503534	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtgctctggaaacattaatAaagcaacctatcagagagaa	9	7	2	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr5:118503534A>G	uc003ksd.2	+	23	5554	c.5373A>G	c.(5371-5373)ATA>ATG	p.I1791M	DMXL1_uc010jcl.1_Missense_Mutation_p.I1791M	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1791										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AAACATTAATAAAGCAACCTA	0.343													G	118503534	G	G	118503534	3	3	55	1	0	0	0	0	1	0	0	0	4594	352	13	4	5463	4	DMXL1	5	118503534	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08	23647076	118503534	62411726	23	3476											
ABLIM3	22885	broad.mit.edu	37	chr5	148620291	148620291	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agccagttagatgtgaggtcCtccactccaacctcttacca	7	14	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr5:148620291C>G	uc003lpy.2	+	14	1508	c.1257C>G	c.(1255-1257)TCC>TCG	p.S419S	ABLIM3_uc003lpz.1_Silent_p.S419S|ABLIM3_uc003lqa.1_Intron|ABLIM3_uc003lqb.2_Intron|ABLIM3_uc003lqc.1_Intron|ABLIM3_uc003lqd.1_Intron|ABLIM3_uc003lqf.2_Intron|ABLIM3_uc003lqe.1_Intron	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	419					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTGAGGTCCTCCACTCCAA	0.572													G	148620291	G	G	148620291	2	3	55	1	0	0	0	0	0	0	0	1	96	668	24	5		5	ABLIM3	5	148620291	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08	30116757	148620291	32294969	24	3477											
SLIT3	6586	broad.mit.edu	37	chr5	168112727	168112727	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcctggggtcggaccttggCggaggccagttccacgtagg	18	11	0	0	rs150873620	by1000genomes	TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr5:168112727C>T	uc003mab.2	-	31	3940	c.3520G>A	c.(3520-3522)GCC>ACC	p.A1174T	SLIT3_uc010jjg.2_Missense_Mutation_p.A1181T	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1174	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding	p.A1174T(1)		ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CGGACCTTGGCGGAGGCCAGT	0.627													T	168112727	T	T	168112727	3	4	55	1	0	0	0	0	1	0	0	0	14741	768	27	1	1075	1	SLIT3	5	168112727	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	19492436	168112727	12802533	25	3478											
STK10	6793	broad.mit.edu	37	chr5	171479966	171479966	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaagcttgtcccgccattcCttcaggttctggttatggct	10	12	2	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr5:171479966C>T	uc003mbo.1	-	18	3033	c.2733G>A	c.(2731-2733)AAG>AAA	p.K911K		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	911	Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCCGCCATTCCTTCAGGTTCT	0.567													T	171479966	T	T	171479966	2	4	55	1	0	0	0	0	0	0	0	1	15285	680	24	3		3	STK10	5	171479966	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08	3367239	171479966	9435294	26	3479											
LMAN2	10960	broad.mit.edu	37	chr5	176765541	176765541	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgatgccgtctccatggagGttcttcttccctgtgccgtg	12	13	3	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr5:176765541G>A	uc003mge.2	-	3	618	c.381C>T	c.(379-381)AAC>AAT	p.N127N	LMAN2_uc003mgd.2_Silent_p.N127N	NM_006816	NP_006807	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2 precursor	127	Lumenal (Potential).|L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCCATGGAGGTTCTTCTTCC	0.632													A	176765541	A	A	176765541	2	1	55	1	0	0	0	0	0	0	0	1	8838	1252	44	3		3	LMAN2	5	176765541	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08	5285575	176765541	4149719	27	3480											
CANX	821	broad.mit.edu	37	chr5	179132740	179132740	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggaactgctattgttgagGctcatgatggacatgatgat	12	5	1	4			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr5:179132740G>A	uc003mkk.2	+	2	235	c.58G>A	c.(58-60)GCT>ACT	p.A20T	CANX_uc011dgp.1_Missense_Mutation_p.A55T|CANX_uc010jlb.1_Missense_Mutation_p.A20T|CANX_uc003mkl.2_Missense_Mutation_p.A20T|CANX_uc011dgq.1_5'UTR	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	20					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	tattgttgaggctcatgatgg	0.104													A	179132740	A	A	179132740	3	1	55	1	0	0	0	0	1	0	0	0	2618	1203	42	3	60	3	CANX	5	179132740	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	2367199	179132740	1782520	28	3481											
ABCF1	23	broad.mit.edu	37	chr6	30552069	30552069	+	Frame_Shift_Del	DEL	G	-	-													cggcggcttcagggacagctGgaacaaggggatgacacagc							TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr6:30552069delG	uc003nql.2	+	13	1298	c.1203delG	c.(1201-1203)CTGfs	p.L401fs	ABCF1_uc003nqk.2_Frame_Shift_Del_p.L402fs|ABCF1_uc003nqm.2_Frame_Shift_Del_p.L363fs|ABCF1_uc010jsb.2_Intron|MIR877_hsa-mir-877|MI0005561_5'Flank	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	401	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						AGGGACAGCTGGAACAAGGGG	0.592													-	30552069	-	-	30552069	7	5	55	1	0	1	0	1	0	0	0	0	65	1335	47	0	1253	0	ABCF1	6	30552069	Frame_Shift_Del	DEL	G	TCGA-06-0648-01A-01W-0323-08		30552069	140562998	29	3482											
LRFN2	57497	broad.mit.edu	37	chr6	40359856	40359856	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcacgacccctcccgccgcCgcagcagcaaagtcccccat	9	21	0	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr6:40359856C>T	uc003oph.1	-	3	2661	c.2196G>A	c.(2194-2196)GCG>GCA	p.A732A		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	732	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTCCCGCCGCCGCAGCAGCAA	0.682													T	40359856	T	T	40359856	2	4	55	1	0	0	0	0	0	0	0	1	8938	639	23	2		2	LRFN2	6	40359856	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08	9807787	40359856	130755211	30	3483											
UNC5CL	222643	broad.mit.edu	37	chr6	40996138	40996138	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctcgtccagctccaggcCctggttatcccgggcgcccc	10	19	1	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr6:40996138C>T	uc003opi.2	-	9	1620	c.1531G>A	c.(1531-1533)GGC>AGC	p.G511S		NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	511	Cytoplasmic (Potential).				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCTCCAGGCCCTGGTTATCC	0.687											OREG0017423	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	40996138	T	T	40996138	3	4	55	1	0	0	0	0	1	0	0	0	16991	623	22	3	29	3	UNC5CL	6	40996138	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	636282	40996138	130118929	31	3484											
SMPD2	6610	broad.mit.edu	37	chr6	109764877	109764877	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgtgtcctggcggctggAggaggggccggggaagctgc	21	9	0	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr6:109764877A>G	uc003pti.2	+	10	1435	c.1041A>G	c.(1039-1041)GGA>GGG	p.G347G	PPIL6_uc003pth.1_5'Flank	NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	347	Helical; (Potential).				induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		TGGCGGCTGGAGGAGGGGCCG	0.632													G	109764877	G	G	109764877	2	3	55	1	0	0	0	0	0	0	0	1	14805	291	11	4		4	SMPD2	6	109764877	Silent	SNP	A	TCGA-06-0648-01A-01W-0323-08	68768739	109764877	61350190	32	3485											
UTRN	7402	broad.mit.edu	37	chr6	144809879	144809879	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aactgaccagatgcttcaagTcttgcaagagagcttggggg	13	8	2	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr6:144809879T>A	uc003qkt.2	+	29	4135	c.4043T>A	c.(4042-4044)GTC>GAC	p.V1348D		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1348	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATGCTTCAAGTCTTGCAAGAG	0.483													A	144809879	A	A	144809879	3	1	55	1	0	0	0	0	1	0	0	0	17100	1667	58	5	4157	5	UTRN	6	144809879	Missense_Mutation	SNP	T	TCGA-06-0648-01A-01W-0323-08	35045002	144809879	26305188	33	3486											
SLC29A4	222962	broad.mit.edu	37	chr7	5330480	5330480	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacggacgtggactacctgcAtcacaagtacccaggtgggt	12	12	1	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr7:5330480A>G	uc003sod.2	+	3	448	c.287A>G	c.(286-288)CAT>CGT	p.H96R	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Missense_Mutation_p.H96R|SLC29A4_uc003soe.2_Missense_Mutation_p.H96R	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	96	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		GACTACCTGCATCACAAGTAC	0.627													G	5330480	G	G	5330480	3	3	55	1	0	0	0	0	1	0	0	0	14537	217	8	4	293	4	SLC29A4	7	5330480	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08		5330480	153808183	34	3487											
STK31	56164	broad.mit.edu	37	chr7	23830449	23830449	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tattgtttttgcagagtcagCgagcctcggtgaacatgatg	12	7	1	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr7:23830449C>T	uc003sws.3	+	22	2711	c.2644C>T	c.(2644-2646)CGA>TGA	p.R882*	STK31_uc003swt.3_Nonsense_Mutation_p.R859*|STK31_uc011jze.1_Nonsense_Mutation_p.R882*|STK31_uc010kuq.2_Nonsense_Mutation_p.R859*|STK31_uc003swv.1_Nonsense_Mutation_p.R48*	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	882	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						GCAGAGTCAGCGAGCCTCGGT	0.378													T	23830449	T	T	23830449	4	4	55	1	0	0	0	0	0	1	0	0	15295	760	27	1	2730	1	STK31	7	23830449	Nonsense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	18499969	23830449	135308214	35	3488											
EGFR	1956	broad.mit.edu	37	chr7	55233035	55233035	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccactgcgtcaagacctgCccggcaggagtcatgggaga	13	14	2	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr7:55233035C>T	uc003tqk.2	+	15	2031	c.1785C>T	c.(1783-1785)TGC>TGT	p.C595C	EGFR_uc003tqi.2_Silent_p.C595C|EGFR_uc003tqj.2_Silent_p.C595C|EGFR_uc010kzg.1_Silent_p.C550C|EGFR_uc011kco.1_Silent_p.C542C|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	595	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCAAGACCTGCCCGGCAGGAG	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233035	T	T	55233035	2	4	55	1	0	0	0	0	0	0	0	1	4967	747	26	3		3	EGFR	7	55233035	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08	31402586	55233035	103905628	36	3489											
MCM4	4173	broad.mit.edu	37	chr8	48889249	48889249	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctttctcttccccacaggcaAttactaaagatatgtttgaa	5	10	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr8:48889249A>G	uc003xqk.1	+	17	2598	c.2503A>G	c.(2503-2505)ATT>GTT	p.I835V	MCM4_uc003xql.1_Missense_Mutation_p.I835V|MCM4_uc011ldi.1_Missense_Mutation_p.I822V	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	835					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CCCACAGGCAATTACTAAAGA	0.423													G	48889249	G	G	48889249	3	3	55	1	0	0	0	0	1	0	0	0	9389	101	4	4	2565	4	MCM4	8	48889249	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08		48889249	97474773	37	3490											
TTC39B	158219	broad.mit.edu	37	chr9	15185345	15185345	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacgccgagccttcctcacaGcaaacttctcagtagggata	8	13	2	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr9:15185345G>A	uc003zlr.1	-	16	1470	c.1349C>T	c.(1348-1350)GCT>GTT	p.A450V	TTC39B_uc003zlq.1_Missense_Mutation_p.A419V|TTC39B_uc011lmp.1_Missense_Mutation_p.A351V|TTC39B_uc010mie.1_Missense_Mutation_p.A448V|TTC39B_uc011lmq.1_Missense_Mutation_p.A437V|TTC39B_uc011lmr.1_Missense_Mutation_p.A381V|TTC39B_uc003zlp.1_Missense_Mutation_p.A33V	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	450							binding			ovary(1)	1						CTTCCTCACAGCAAACTTCTC	0.507													A	15185345	A	A	15185345	3	1	55	1	0	0	0	0	1	0	0	0	16705	971	34	3	521	3	TTC39B	9	15185345	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08		15185345	126028086	38	3491											
C9orf125	84302	broad.mit.edu	37	chr9	104238682	104238682	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgagatgtggctcagagaaGcgagcccgcagaaggtgctc	15	10	1	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr9:104238682G>A	uc004bbm.2	-	2	1015	c.693C>T	c.(691-693)CGC>CGT	p.R231R	uc004bbl.1_5'Flank	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	hypothetical protein LOC84302	231						integral to membrane					0		Acute lymphoblastic leukemia(62;0.0527)				GCTCAGAGAAGCGAGCCCGCA	0.542													A	104238682	A	A	104238682	2	1	55	1	0	0	0	0	0	0	0	1	2454	958	34	3		3	C9orf125	9	104238682	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08	89053337	104238682	36974749	39	3492											
SMC2	10592	broad.mit.edu	37	chr9	106885401	106885401	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttgtaaggtatcgccaactAaaacagcagtgggagatgaa	11	6	0	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr9:106885401A>G	uc004bbv.2	+	17	2433	c.2145A>G	c.(2143-2145)CTA>CTG	p.L715L	SMC2_uc004bbu.1_Silent_p.L715L|SMC2_uc004bbw.2_Silent_p.L715L|SMC2_uc011lvl.1_Silent_p.L715L|SMC2_uc004bbx.2_Silent_p.L715L	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	715	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						ATCGCCAACTAAAACAGCAGT	0.348													G	106885401	G	G	106885401	2	3	55	1	0	0	0	0	0	0	0	1	14783	349	13	4		4	SMC2	9	106885401	Silent	SNP	A	TCGA-06-0648-01A-01W-0323-08	2646719	106885401	34328030	40	3493											
COL27A1	85301	broad.mit.edu	37	chr9	117071558	117071558	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtcgagtttgccatcagcCgggtccagatgaatttcctg	12	10	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr9:117071558C>T	uc011lxl.1	+	60	5236	c.5236C>T	c.(5236-5238)CGG>TGG	p.R1746W	COL27A1_uc004bii.2_RNA|COL27A1_uc011lxn.1_Missense_Mutation_p.R61W	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1746	Fibrillar collagen NC1.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						TGCCATCAGCCGGGTCCAGAT	0.607													T	117071558	T	T	117071558	3	4	55	1	0	0	0	0	1	0	0	0	3685	643	23	2	5474	2	COL27A1	9	117071558	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	10186157	117071558	24141873	41	3494											
ATP6V1G1	9550	broad.mit.edu	37	chr9	117359986	117359986	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcttttgtctgtgacattcGgccagaaatccatgaaaact	9	9	1	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr9:117359986G>A	uc004bjc.2	+	3	445	c.320G>A	c.(319-321)CGG>CAG	p.R107Q		NM_004888	NP_004879	O75348	VATG1_HUMAN	vacuolar H+ ATPase G1	107					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances				0						TGTGACATTCGGCCAGAAATC	0.478													A	117359986	A	A	117359986	3	1	55	1	0	0	0	0	1	0	0	0	1186	1116	39	2	330	2	ATP6V1G1	9	117359986	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	288428	117359986	23853445	42	3495											
NELF	26012	broad.mit.edu	37	chr9	140351900	140351900	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acatcctctccagcttcttgCggcgaccggaggtctcaggc	11	15	3	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr9:140351900C>T	uc004cna.2	-	3	819	c.587G>A	c.(586-588)CGC>CAC	p.R196H	C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_5'Flank|NELF_uc010nci.2_5'Flank|NELF_uc011mey.1_RNA|NELF_uc011mez.1_Missense_Mutation_p.R196H|NELF_uc004cmz.2_Missense_Mutation_p.R196H|NELF_uc004cnc.2_Missense_Mutation_p.R196H|NELF_uc004cnb.2_Missense_Mutation_p.R196H	NM_001130969	NP_001124441	Q6X4W1	NELF_HUMAN	nasal embryonic LHRH factor isoform a	196						nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)		CAGCTTCTTGCGGCGACCGGA	0.652													T	140351900	T	T	140351900	3	4	55	1	0	0	0	0	1	0	0	0	10332	768	27	1	1071	1	NELF	9	140351900	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	22991914	140351900	861531	43	3496											
SLC39A12	221074	broad.mit.edu	37	chr10	18270258	18270258	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagacctgcttctctgctagGcagctggtggagatatttct	11	10	2	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr10:18270258G>A	uc001ipo.2	+	6	1215	c.942G>A	c.(940-942)AGG>AGA	p.R314R	SLC39A12_uc001ipn.2_Silent_p.R314R|SLC39A12_uc001ipp.2_Silent_p.R314R|SLC39A12_uc010qck.1_Silent_p.R180R	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	314	Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TCTCTGCTAGGCAGCTGGTGG	0.448													A	18270258	A	A	18270258	2	1	55	1	0	0	0	0	0	0	0	1	14615	1194	42	3		3	SLC39A12	10	18270258	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08		18270258	117264489	44	3497											
FAM196A	642938	broad.mit.edu	37	chr10	128973691	128973691	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccggcggggtgtgagtctgCgacggctgctcactacattc	14	13	2	1	rs139302074	byFrequency	TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr10:128973691C>T	uc001lju.1	-	1	1010	c.969G>A	c.(967-969)TCG>TCA	p.S323S	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Silent_p.S323S|FAM196A_uc001ljv.1_Silent_p.S323S|FAM196A_uc009yap.1_Silent_p.S323S	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	323										ovary(2)	2						TGTGAGTCTGCGACGGCTGCT	0.642													T	128973691	T	T	128973691	2	4	55	1	0	0	0	0	0	0	0	1	5528	755	27	1		1	FAM196A	10	128973691	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08	110703433	128973691	6561056	45	3498											
MRPL23	6150	broad.mit.edu	37	chr11	1973439	1973439	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgcggacacgggtgcagcatGgtgagtgcccatgggaggtt	18	8	0	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr11:1973439G>C	uc001lux.2	+	3	314	c.223G>C	c.(223-225)GGC>CGC	p.G75R		NM_021134	NP_066957	Q16540	RM23_HUMAN	mitochondrial ribosomal protein L23	75					translation	mitochondrial large ribosomal subunit	nucleotide binding|RNA binding|structural constituent of ribosome			large_intestine(2)|ovary(1)	3		all_epithelial(84;6.24e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.0026)|Lung(200;0.0171)|LUSC - Lung squamous cell carcinoma(625;0.0842)		GGTGCAGCATGGTGAGTGCCC	0.602													C	1973439	C	C	1973439	3	2	55	1	0	0	0	0	1	0	0	0	9789	1362	47	5	233	5	MRPL23	11	1973439	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08		1973439	133033077	46	3499											
ANO5	203859	broad.mit.edu	37	chr11	22239813	22239813	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaaagcgattcaatttgTtcctgaggcggcggcttatg	12	9	1	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr11:22239813T>G	uc001mqi.2	+	4	477	c.160T>G	c.(160-162)TTC>GTC	p.F54V	ANO5_uc001mqj.2_Missense_Mutation_p.F53V	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	54	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ATTCAATTTGTTCCTGAGGCG	0.403													G	22239813	G	G	22239813	3	3	55	1	0	0	0	0	1	0	0	0	700	1725	60	5	174	5	ANO5	11	22239813	Missense_Mutation	SNP	T	TCGA-06-0648-01A-01W-0323-08	20266374	22239813	112766703	47	3500											
OR5D16	390144	broad.mit.edu	37	chr11	55606889	55606889	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	catcattctgacatcttatgCattcatcattgtcaccacct	3	13	6	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr11:55606889C>A	uc010rio.1	+	1	662	c.662C>A	c.(661-663)GCA>GAA	p.A221E		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				ACATCTTATGCATTCATCATT	0.468													A	55606889	A	A	55606889	3	1	55	1	0	0	0	0	1	0	0	0	11156	710	25	5	664	5	OR5D16	11	55606889	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	33367076	55606889	79399627	48	3501											
OR5D16	390144	broad.mit.edu	37	chr11	55606937	55606937	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccttcagccagtgggcaccGcaaagtcttctccacctgtg	10	15	3	0	rs148616685		TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr11:55606937G>A	uc010rio.1	+	1	710	c.710G>A	c.(709-711)CGC>CAC	p.R237H		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				AGTGGGCACCGCAAAGTCTTC	0.488													A	55606937	A	A	55606937	3	1	55	1	0	0	0	0	1	0	0	0	11156	1087	38	1	712	1	OR5D16	11	55606937	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	48	55606937	79399579	49	3502											
OR5M3	219482	broad.mit.edu	37	chr11	56237927	56237927	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgccattctcgacggctcGttagccccaaaagaatgaac	8	13	1	2	rs147367874	byFrequency	TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr11:56237927G>A	uc010rjk.1	-	1	47	c.47C>T	c.(46-48)ACG>ATG	p.T16M		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TCGACGGCTCGTTAGCCCCAA	0.383													A	56237927	A	A	56237927	3	1	55	1	0	0	0	0	1	0	0	0	11175	1145	40	1	878	1	OR5M3	11	56237927	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	630990	56237927	78768589	50	3503											
ANO1	55107	broad.mit.edu	37	chr11	69949227	69949227	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccccctggaacgtgctgtGcagagaggccgagtttctga	14	11	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr11:69949227G>A	uc001opj.2	+	3	802	c.497G>A	c.(496-498)TGC>TAC	p.C166Y	ANO1_uc001opk.1_Missense_Mutation_p.C138Y|ANO1_uc001opl.1_RNA	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	166	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						AACGTGCTGTGCAGAGAGGCC	0.532													A	69949227	A	A	69949227	3	1	55	1	0	0	0	0	1	0	0	0	695	1319	46	3	507	3	ANO1	11	69949227	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	13711300	69949227	65057289	51	3504											
PAAF1	80227	broad.mit.edu	37	chr11	73627614	73627614	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctctttattggctcagacGctttcaactgctgtactttt	6	11	3	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr11:73627614G>A	uc001ouk.1	+	9	878	c.844G>A	c.(844-846)GCT>ACT	p.A282T	PAAF1_uc001oul.1_Missense_Mutation_p.A265T|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Missense_Mutation_p.A265T|PAAF1_uc001oun.1_5'Flank	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	282	WD 4.				interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)					TGGCTCAGACGCTTTCAACTG	0.423													A	73627614	A	A	73627614	3	1	55	1	0	0	0	0	1	0	0	0	11362	1087	38	1	878	1	PAAF1	11	73627614	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	3678387	73627614	61378902	52	3505											
XRRA1	143570	broad.mit.edu	37	chr11	74559419	74559419	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctctgcctctggctctagcAtatcctttgagggagacttg	11	11	3	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr11:74559419A>G	uc009yub.2	-	15	1777	c.1445T>C	c.(1444-1446)ATG>ACG	p.M482T	XRRA1_uc001ovm.2_RNA|XRRA1_uc001ovn.2_Missense_Mutation_p.M105T|XRRA1_uc001ovo.2_Missense_Mutation_p.M90T|XRRA1_uc001ovq.3_Missense_Mutation_p.M395T|XRRA1_uc001ovp.3_Missense_Mutation_p.M207T|XRRA1_uc001ovr.2_Missense_Mutation_p.M105T|XRRA1_uc001ovs.1_Missense_Mutation_p.M84T	NM_182969	NP_892014	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	482					response to X-ray	cytoplasm|nucleus				central_nervous_system(1)	1						TGGCTCTAGCATATCCTTTGA	0.552													G	74559419	G	G	74559419	3	3	55	1	0	0	0	0	1	0	0	0	17458	217	8	4	953	4	XRRA1	11	74559419	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08	931805	74559419	60447097	53	3506											
ADAMTS8	11095	broad.mit.edu	37	chr11	130281492	130281492	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcccagcctccatctgccaCgggctgcaacatacaatggc	9	16	1	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr11:130281492C>T	uc001qgg.3	-	6	1928	c.1570G>A	c.(1570-1572)GTG>ATG	p.V524M	ADAMTS8_uc001qgf.2_Missense_Mutation_p.V5M	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	524	Disintegrin.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CCATCTGCCACGGGCTGCAAC	0.577													T	130281492	T	T	130281492	3	4	55	1	0	0	0	0	1	0	0	0	272	536	19	1	1115	1	ADAMTS8	11	130281492	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	55722073	130281492	4725024	54	3507											
KRT4	3851	broad.mit.edu	37	chr12	53208029	53208029	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcccatccttcccgcacccGttgagcatgtcactaaacac	6	17	1	1	rs143824965	by1000genomes	TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr12:53208029G>A	uc001saz.2	-	1	307	c.36C>T	c.(34-36)AAC>AAT	p.N12N		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	Error:Variant_position_missing_in_B4DRS2_after_alignment						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						TCCCGCACCCGTTGAGCATGT	0.542													A	53208029	A	A	53208029	2	1	55	1	0	0	0	0	0	0	0	1	8477	1136	40	1		1	KRT4	12	53208029	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08		53208029	80643866	55	3508											
MYO1A	4640	broad.mit.edu	37	chr12	57432332	57432332	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaaacaaggaccgaaggaGggggtgctgggccttccaca	16	9	0	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr12:57432332G>A	uc001smw.3	-	17	1867	c.1624C>T	c.(1624-1626)CTC>TTC	p.L542F	MYO1A_uc010sqz.1_Missense_Mutation_p.L380F|MYO1A_uc009zpd.2_Missense_Mutation_p.L542F	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	542	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						GACCGAAGGAGGGGGTGCTGG	0.537													A	57432332	A	A	57432332	3	1	55	1	0	0	0	0	1	0	0	0	10068	1000	35	3	1555	3	MYO1A	12	57432332	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	4224303	57432332	76419563	56	3509											
C12orf66	144577	broad.mit.edu	37	chr12	64588399	64588399	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggacgtcaacttccagctgGaaactgctttccaaaggact	9	11	1	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr12:64588399G>A	uc001srw.3	-	3	620	c.561C>T	c.(559-561)TTC>TTT	p.F187F	C12orf66_uc009zql.2_Silent_p.F134F	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	187										ovary(1)	1						CTTCCAGCTGGAAACTGCTTT	0.478													A	64588399	A	A	64588399	2	1	55	1	0	0	0	0	0	0	0	1	1709	1165	41	3		3	C12orf66	12	64588399	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08	7156067	64588399	69263496	57	3510											
KSR2	283455	broad.mit.edu	37	chr12	118016952	118016952	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttacacttgaggccaaaaaGcatccctttcccacagactg	6	13	0	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr12:118016952G>A	uc001two.2	-	7	1265	c.1210C>T	c.(1210-1212)CTT>TTT	p.L404F		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	433	Phorbol-ester/DAG-type.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity	p.L465F(1)		lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGCCAAAAAGCATCCCTTTC	0.478													A	118016952	A	A	118016952	3	1	55	1	0	0	0	0	1	0	0	0	8582	971	34	3	1611	3	KSR2	12	118016952	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	53428553	118016952	15834943	58	3511											
CCDC60	160777	broad.mit.edu	37	chr12	119866567	119866567	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaggaccttatacgaagccGgtgagtgagcccagcaggga	14	9	0	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr12:119866567G>A	uc001txe.2	+	2	635	c.170G>A	c.(169-171)CGC>CAC	p.R57H	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	57										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		ATACGAAGCCGGTGAGTGAGC	0.502													A	119866567	A	A	119866567	3	1	55	1	0	0	0	0	1	0	0	0	2831	1130	39	2	176	2	CCDC60	12	119866567	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	1849615	119866567	13985328	59	3512											
GPR133	283383	broad.mit.edu	37	chr12	131487816	131487816	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgcacggcagcacgccccaGgtcaccgtggagggctcctc	13	17	1	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr12:131487816G>T	uc001uit.3	+	10	1672	c.1113G>T	c.(1111-1113)CAG>CAT	p.Q371H	GPR133_uc010tbm.1_Missense_Mutation_p.Q403H	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	371	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GCACGCCCCAGGTCACCGTGG	0.617													T	131487816	T	T	131487816	3	4	55	1	0	0	0	0	1	0	0	0	6643	991	35	5	1151	5	GPR133	12	131487816	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	11621249	131487816	2364079	60	3513											
DCLK1	9201	broad.mit.edu	37	chr13	36428681	36428681	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggtgggtgatgggcttggCgacttgcctgagcgcggagt	19	8	0	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr13:36428681C>T	uc001uvf.2	-	6	1223	c.990G>A	c.(988-990)TCG>TCA	p.S330S	DCLK1_uc001uve.3_Silent_p.S23S|DCLK1_uc010teh.1_Silent_p.S23S|DCLK1_uc010abk.2_Silent_p.S23S|DCLK1_uc001uvh.3_RNA	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	330	Pro/Ser-rich.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		ATGGGCTTGGCGACTTGCCTG	0.493													T	36428681	T	T	36428681	2	4	55	1	0	0	0	0	0	0	0	1	4291	755	27	1		1	DCLK1	13	36428681	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08		36428681	78741197	61	3514											
GRK1	6011	broad.mit.edu	37	chr13	114321752	114321752	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaactctgccttcatcgcCgcccgaggcagctttgacgg	11	16	2	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr13:114321752C>T	uc010tkf.1	+	1	159	c.51C>T	c.(49-51)GCC>GCT	p.A17A		NM_002929	NP_002920	Q15835	RK_HUMAN	rhodopsin kinase precursor	17	N-terminal.				regulation of G-protein coupled receptor protein signaling pathway|rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|rhodopsin kinase activity|signal transducer activity			ovary(2)	2	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.234)			CCTTCATCGCCGCCCGAGGCA	0.647													T	114321752	T	T	114321752	2	4	55	1	0	0	0	0	0	0	0	1	6790	639	23	2		2	GRK1	13	114321752	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08	77893071	114321752	848126	62	3515											
SCFD1	23256	broad.mit.edu	37	chr14	31139520	31139520	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggagtggaaaactctccagCtggtgctagaccaaagagaa	12	8	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr14:31139520C>G	uc001wqm.1	+	11	938	c.914C>G	c.(913-915)GCT>GGT	p.A305G	SCFD1_uc001wqn.1_Missense_Mutation_p.A238G|SCFD1_uc010tpg.1_Missense_Mutation_p.A246G|SCFD1_uc010tph.1_Missense_Mutation_p.A120G|SCFD1_uc010amf.1_Missense_Mutation_p.A120G|SCFD1_uc010tpi.1_Missense_Mutation_p.A213G|SCFD1_uc010amd.1_Missense_Mutation_p.A137G|SCFD1_uc010ame.1_Missense_Mutation_p.A238G	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	305					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		AACTCTCCAGCTGGTGCTAGA	0.328													G	31139520	G	G	31139520	3	3	55	1	0	0	0	0	1	0	0	0	13889	797	28	5	956	5	SCFD1	14	31139520	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08		31139520	76210020	63	3516											
FANCM	57697	broad.mit.edu	37	chr14	45665510	45665510	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gtattcttgtaggtggtcatGaaatcacttctggattagaa	10	5	4	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr14:45665510G>A	uc001wwd.3	+	21	5575	c.5476G>A	c.(5476-5478)GAA>AAA	p.E1826K	FANCM_uc010anf.2_Missense_Mutation_p.E1800K|FANCM_uc001wwe.3_Missense_Mutation_p.E1362K|FANCM_uc010ang.2_Missense_Mutation_p.E1075K	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1826	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						AGGTGGTCATGAAATCACTTC	0.418								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				A	45665510	A	A	45665510	3	1	55	1	0	0	0	0	1	0	0	0	5671	1291	45	3	5558	3	FANCM	14	45665510	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	14525990	45665510	61684030	64	3517											
ESR2	2100	broad.mit.edu	37	chr14	64727172	64727172	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gccagaaagccctaccgggaAtcttcttggcccagctgatc	10	14	2	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr14:64727172A>T	uc001xha.1	-	5	1415	c.947T>A	c.(946-948)ATT>AAT	p.I316N	ESR2_uc001xgu.2_Missense_Mutation_p.I316N|ESR2_uc001xgv.2_Missense_Mutation_p.I316N|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Missense_Mutation_p.I316N|ESR2_uc001xgy.1_Missense_Mutation_p.I316N|ESR2_uc001xgz.1_Missense_Mutation_p.I316N|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Missense_Mutation_p.I316N|ESR2_uc010aqd.1_RNA	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	316	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	CCTACCGGGAATCTTCTTGGC	0.398													T	64727172	T	T	64727172	3	4	55	1	0	0	0	0	1	0	0	0	5257	101	4	5	751	5	ESR2	14	64727172	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08	19061662	64727172	42622368	65	3518											
SERPINA6	866	broad.mit.edu	37	chr14	94780400	94780400	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagatatagttgaccaggaCgaggatggctgggctatcca	14	7	0	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr14:94780400C>T	uc001ycv.2	-	2	690	c.586G>A	c.(586-588)GTC>ATC	p.V196I	SERPINA6_uc010auv.2_RNA	NM_001756	NP_001747	P08185	CBG_HUMAN	corticosteroid binding globulin precursor	196					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			skin(3)|ovary(1)|central_nervous_system(1)	5		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TTGACCAGGACGAGGATGGCT	0.502													T	94780400	T	T	94780400	3	4	55	1	0	0	0	0	1	0	0	0	14093	536	19	1	647	1	SERPINA6	14	94780400	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	30053228	94780400	12569140	66	3519											
AHNAK2	113146	broad.mit.edu	37	chr14	105410846	105410846	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccctggggccgataccctgaAtgacggcatcttgaatttgg	12	11	1	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr14:105410846A>G	uc010axc.1	-	7	11062	c.10942T>C	c.(10942-10944)TTC>CTC	p.F3648L	AHNAK2_uc001ypx.2_Missense_Mutation_p.F3548L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3648						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GATACCCTGAATGACGGCATC	0.592													G	105410846	G	G	105410846	3	3	55	1	0	0	0	0	1	0	0	0	415	101	4	4	6449	4	AHNAK2	14	105410846	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08	10630446	105410846	1938694	67	3520											
AHNAK2	113146	broad.mit.edu	37	chr14	105417866	105417866	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggtccccgtccagctgtgCgccatccaacttggctcccg	10	18	0	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr14:105417866C>T	uc010axc.1	-	7	4042	c.3922G>A	c.(3922-3924)GCA>ACA	p.A1308T	AHNAK2_uc001ypx.2_Missense_Mutation_p.A1208T	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1308						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCCAGCTGTGCGCCATCCAAC	0.597													T	105417866	T	T	105417866	3	4	55	1	0	0	0	0	1	0	0	0	415	768	27	1	13469	1	AHNAK2	14	105417866	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	7020	105417866	1931674	68	3521											
DUOX2	50506	broad.mit.edu	37	chr15	45392270	45392270	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taagcacgatctgcaaacacGccaacacagatggccgagaa	9	12	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr15:45392270G>A	uc010bea.2	-	24	3365	c.3162C>T	c.(3160-3162)GGC>GGT	p.G1054G	DUOX2_uc001zun.2_Silent_p.G1054G	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1054	Interaction with TXNDC11 (By similarity).|Helical; (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CTGCAAACACGCCAACACAGA	0.562													A	45392270	A	A	45392270	2	1	55	1	0	0	0	0	0	0	0	1	4801	1074	38	1		1	DUOX2	15	45392270	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08		45392270	57139122	69	3522											
FBXO22	26263	broad.mit.edu	37	chr15	76205599	76205599	+	Frame_Shift_Del	DEL	T	-	-													ggctgattcagaaactttcaTtagtctggaagagtgtcgtg							TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr15:76205599delT	uc002bbk.2	+	3	440	c.335delT	c.(334-336)ATTfs	p.I112fs	FBXO22_uc002bbj.1_Frame_Shift_Del_p.I112fs|FBXO22_uc002bbl.2_Frame_Shift_Del_p.I8fs	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	F-box only protein 22 isoform a	112					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity				0						GAAACTTTCATTAGTCTGGAA	0.358													-	76205599	-	-	76205599	7	5	55	1	0	1	0	1	0	0	0	0	5734	1493	52	0	345	0	FBXO22	15	76205599	Frame_Shift_Del	DEL	T	TCGA-06-0648-01A-01W-0323-08	30813329	76205599	26325793	70	3523											
SYNM	23336	broad.mit.edu	37	chr15	99670079	99670079	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaacagaagtgaaagccaCgagggagcaagaaagaaaca	12	6	0	4			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr15:99670079C>T	uc002bup.2	+	6	1634	c.1514C>T	c.(1513-1515)ACG>ATG	p.T505M	SYNM_uc002buo.2_Missense_Mutation_p.T505M|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	505	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						GTGAAAGCCACGAGGGAGCAA	0.488													T	99670079	T	T	99670079	3	4	55	1	0	0	0	0	1	0	0	0	15452	536	19	1	1527	1	SYNM	15	99670079	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	23464480	99670079	2861313	71	3524											
LRRK1	79705	broad.mit.edu	37	chr15	101586198	101586198	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtttcagctacctcctgccCcatctccttccatctaaacc	3	18	3	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr15:101586198C>T	uc002bwr.2	+	21	3295	c.2976C>T	c.(2974-2976)CCC>CCT	p.P992P	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	992					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ACCTCCTGCCCCATCTCCTTC	0.592													T	101586198	T	T	101586198	2	4	55	1	0	0	0	0	0	0	0	1	9032	610	22	3		3	LRRK1	15	101586198	Silent	SNP	C	TCGA-06-0648-01A-01W-0323-08	1916119	101586198	945194	72	3525											
SPIRE2	84501	broad.mit.edu	37	chr16	89916966	89916966	+	Frame_Shift_Del	DEL	C	-	-													tgcgcggcgcggctgaccgaCccccggggcgcacaggcgca							TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr16:89916966delC	uc002foz.1	+	3	595	c.543delC	c.(541-543)GACfs	p.D181fs	SPIRE2_uc010civ.1_Frame_Shift_Del_p.D96fs|SPIRE2_uc010ciw.1_Frame_Shift_Del_p.D181fs|SPIRE2_uc002fpa.1_Frame_Shift_Del_p.D133fs|SPIRE2_uc010cix.1_Frame_Shift_Del_p.D50fs	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	181	KIND.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GGCTGACCGACCCCCGGGGCG	0.751													-	89916966	-	-	89916966	7	5	55	1	0	1	0	1	0	0	0	0	15071	506	18	0	553	0	SPIRE2	16	89916966	Frame_Shift_Del	DEL	C	TCGA-06-0648-01A-01W-0323-08		89916966	437787	73	3526											
OR3A2	4995	broad.mit.edu	37	chr17	3181738	3181738	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacagtgtgggtcagtgcGttggtgaaggcacaagccaa	15	9	1	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr17:3181738G>A	uc002fvg.2	-	1	531	c.492C>T	c.(490-492)AAC>AAT	p.N164N		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	164	Helical; Name=4; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GGGTCAGTGCGTTGGTGAAGG	0.582													A	3181738	A	A	3181738	2	1	55	1	0	0	0	0	0	0	0	1	11038	1136	40	1		1	OR3A2	17	3181738	Silent	SNP	G	TCGA-06-0648-01A-01W-0323-08		3181738	78013472	74	3527											
DNAH2	146754	broad.mit.edu	37	chr17	7736507	7736507	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgcccacgatccacttccGgcctgcagagagccgcaaga	10	16	0	2	rs145226741		TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr17:7736507G>A	uc002giu.1	+	84	13111	c.13097G>A	c.(13096-13098)CGG>CAG	p.R4366Q		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4366					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ATCCACTTCCGGCCTGCAGAG	0.622													A	7736507	A	A	7736507	3	1	55	1	0	0	0	0	1	0	0	0	4602	1116	39	2	13431	2	DNAH2	17	7736507	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	4554769	7736507	73458703	75	3528											
MLLT6	4302	broad.mit.edu	37	chr17	36873166	36873166	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctccggcctgggaggtctgtCctcccgaacctttgggcctt	12	15	1	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr17:36873166C>T	uc002hqi.3	+	10	1596	c.1583C>T	c.(1582-1584)TCC>TTC	p.S528F	MLLT6_uc002hqj.2_Intron|MLLT6_uc002hqk.3_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	528					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GGAGGTCTGTCCTCCCGAACC	0.637			T	MLL	AL								T	36873166	T	T	36873166	3	4	55	1	0	0	0	0	1	0	0	0	9630	855	30	3	1621	3	MLLT6	17	36873166	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	29136659	36873166	44322044	76	3529											
OR4D2	124538	broad.mit.edu	37	chr17	56247707	56247707	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgctgaggtcacatccagggGaggcaagaaggaaggcagct	16	8	1	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr17:56247707G>A	uc010wnp.1	+	1	691	c.691G>A	c.(691-693)GAG>AAG	p.E231K		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						ACATCCAGGGGAGGCAAGAAG	0.537													A	56247707	A	A	56247707	3	1	55	1	0	0	0	0	1	0	0	0	11056	1175	41	3	693	3	OR4D2	17	56247707	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	19374541	56247707	24947503	77	3530											
C18orf45	85019	broad.mit.edu	37	chr18	20979531	20979531	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacctctaatacttaccAgtctggacaatgctctggac	7	12	3	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr18:20979531A>T	uc002kuf.2	-	4	387	c.278T>A	c.(277-279)CTG>CAG	p.L93Q	C18orf45_uc010xaq.1_Intron|C18orf45_uc010xar.1_RNA|C18orf45_uc002kug.2_RNA|C18orf45_uc002kuh.2_RNA	NM_032933	NP_116322	Q24JQ0	CR045_HUMAN	hypothetical protein LOC85019	93	Helical; (Potential).					integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)					AATACTTACCAGTCTGGACAA	0.443													T	20979531	T	T	20979531	3	4	55	1	0	0	0	0	1	0	0	0	1903	202	7	5	660	5	C18orf45	18	20979531	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08		20979531	57097717	78	3531											
LGALS13	29124	broad.mit.edu	37	chr19	40095888	40095888	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatattgccttccgtttcCgagtgcactttggcaatcat	8	11	1	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr19:40095888C>T	uc002omb.2	+	3	203	c.163C>T	c.(163-165)CGA>TGA	p.R55*		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13	55	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CTTCCGTTTCCGAGTGCACTT	0.498													T	40095888	T	T	40095888	4	4	55	1	0	0	0	0	0	1	0	0	8740	644	23	2	173	2	LGALS13	19	40095888	Nonsense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08		40095888	19033095	79	3532											
CEACAM7	1087	broad.mit.edu	37	chr19	42187746	42187746	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagggtgactgggtcactgcGgctggcacccactgggttct	15	12	2	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr19:42187746G>A	uc002ori.1	-	3	678	c.676C>T	c.(676-678)CGC>TGC	p.R226C	CEACAM7_uc010ehx.2_Missense_Mutation_p.R226C|CEACAM7_uc010ehy.1_Intron	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	226	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		GGGTCACTGCGGCTGGCACCC	0.552													A	42187746	A	A	42187746	3	1	55	1	0	0	0	0	1	0	0	0	3197	1116	39	2	129	2	CEACAM7	19	42187746	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	2091858	42187746	16941237	80	3533											
BCAM	4059	broad.mit.edu	37	chr19	45322967	45322967	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccctgctgccgccagcggCgggagaagggggctccgtga	18	14	0	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr19:45322967C>T	uc002ozu.2	+	13	1791	c.1747C>T	c.(1747-1749)CGG>TGG	p.R583W	BCAM_uc002ozt.1_Missense_Mutation_p.R583W	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	583	Cytoplasmic (Potential).				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CCGCCAGCGGCGGGAGAAGGG	0.507													T	45322967	T	T	45322967	3	4	55	1	0	0	0	0	1	0	0	0	1344	759	27	1	1797	1	BCAM	19	45322967	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08	3135221	45322967	13806016	81	3534											
FPR2	2358	broad.mit.edu	37	chr19	52272072	52272072	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatctgggtggctggattccGgatgacacgcacagtcacca	13	11	2	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr19:52272072G>A	uc002pxr.2	+	2	206	c.161G>A	c.(160-162)CGG>CAG	p.R54Q	FPR2_uc002pxs.3_Missense_Mutation_p.R54Q|FPR2_uc010epf.2_Missense_Mutation_p.R54Q	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	54	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						GCTGGATTCCGGATGACACGC	0.562													A	52272072	A	A	52272072	3	1	55	1	0	0	0	0	1	0	0	0	6039	1116	39	2	163	2	FPR2	19	52272072	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08	6949105	52272072	6856911	82	3535											
SPTLC3	55304	broad.mit.edu	37	chr20	13029756	13029756	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aatagaaaaatgcaacgcagCtgtggaaagaaaagaacaaa	9	5	0	3			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr20:13029756C>A	uc002wod.1	+	2	570	c.281C>A	c.(280-282)GCT>GAT	p.A94D	SPTLC3_uc002woc.2_Missense_Mutation_p.A94D	NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	94					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	TGCAACGCAGCTGTGGAAAGA	0.423													A	13029756	A	A	13029756	3	1	55	1	0	0	0	0	1	0	0	0	15124	797	28	5	287	5	SPTLC3	20	13029756	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08		13029756	49995764	83	3536											
PLCG1	5335	broad.mit.edu	37	chr20	39788360	39788360	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acattgctttgtcattctctAtggaatggaatttcgcctga	8	8	2	1			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr20:39788360A>G	uc002xjp.1	+	2	453	c.332A>G	c.(331-333)TAT>TGT	p.Y111C	PLCG1_uc002xjo.1_Missense_Mutation_p.Y111C	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	111	PH 1.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GTCATTCTCTATGGAATGGAA	0.537													G	39788360	G	G	39788360	3	3	55	1	0	0	0	0	1	0	0	0	12035	449	16	4	338	4	PLCG1	20	39788360	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08	26758604	39788360	23237160	84	3537											
RRP1B	23076	broad.mit.edu	37	chr21	45107441	45107441	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aagaggacagtgaaagcagtCttcaaaagagaagaaggaag	13	4	2	4			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr21:45107441C>T	uc002zdk.2	+	13	1300	c.1186C>T	c.(1186-1188)CTT>TTT	p.L396F	RRP1B_uc002zdl.2_5'UTR	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	396					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		TGAAAGCAGTCTTCAAAAGAG	0.532													T	45107441	T	T	45107441	3	4	55	1	0	0	0	0	1	0	0	0	13688	913	32	3	1236	3	RRP1B	21	45107441	Missense_Mutation	SNP	C	TCGA-06-0648-01A-01W-0323-08		45107441	3022454	85	3538											
CABIN1	23523	broad.mit.edu	37	chr22	24487684	24487684	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcagcagcagccacccaccGtttacttgctgcactacagg	9	15	0	0			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chr22:24487684G>A	uc002zzi.1	+	24	3800	c.3673G>A	c.(3673-3675)GTT>ATT	p.V1225I	CABIN1_uc002zzj.1_Missense_Mutation_p.V1175I|CABIN1_uc002zzl.1_Missense_Mutation_p.V1225I	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1225					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCCACCCACCGTTTACTTGCT	0.612													A	24487684	A	A	24487684	3	1	55	1	0	0	0	0	1	0	0	0	2528	1145	40	1	3763	1	CABIN1	22	24487684	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08		24487684	26816882	86	3539											
SHOX	6473	broad.mit.edu	37	chrX	591909	591909	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaccgcgagagtggcagaaGgtaagttcctttgcgctccg	14	11	0	2			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chrX:591909G>A	uc004cph.1	+	2	968	c.277G>A	c.(277-279)GGG>AGG	p.G93R	SHOX_uc004cpi.2_Missense_Mutation_p.G93R	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	93					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGTGGCAGAAGGTAAGTTCCT	0.647													A	591909	A	A	591909	3	1	55	1	0	0	0	0	1	0	0	0	14288	1014	35	3	279	3	SHOX	23	591909	Missense_Mutation	SNP	G	TCGA-06-0648-01A-01W-0323-08		591909	154678651	87	3540											
FOXR2	139628	broad.mit.edu	37	chrX	55650926	55650926	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agacagccttaaggatgaagAtaatgcaagacctcgctctt	9	9	1	4			TCGA-06-0648-01A-01W-0323-08	TCGA-06-0648-10A-01W-0323-08									Somatic	Phase_I	Capture				Illumina GAIIx	33f8304e-11c3-4a9d-ad21-ffea555309dc	7a88c445-24c5-4dfd-9064-de5dc2a47b41	g.chrX:55650926A>C	uc004duo.2	+	1	1094	c.782A>C	c.(781-783)GAT>GCT	p.D261A		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	261	Fork-head.				embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						AAGGATGAAGATAATGCAAGA	0.517													C	55650926	C	C	55650926	3	2	55	1	0	0	0	0	1	0	0	0	6032	333	12	5	784	5	FOXR2	23	55650926	Missense_Mutation	SNP	A	TCGA-06-0648-01A-01W-0323-08	55059017	55650926	99619634	88	3541											
TMEM52	339456	broad.mit.edu	37	chr1	1849551	1849551	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggagtccaggtccagctcccCaaagggcaggggcaaccgca	14	14	0	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:1849551C>A	uc001aij.2	-	5	436	c.400G>T	c.(400-402)GGG>TGG	p.G134W	TMEM52_uc001aii.2_Missense_Mutation_p.G119W	NM_178545	NP_848640	Q8NDY8	TMM52_HUMAN	transmembrane protein 52 precursor	134						integral to membrane					0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TCCAGCTCCCCAAAGGGCAGG	0.637													A	1849551	A	A	1849551	3	1	56	1	0	0	0	0	1	0	0	0	16175	594	21	5	233	5	TMEM52	1	1849551	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08		1849551	247401070	1	3542											
ESPN	83715	broad.mit.edu	37	chr1	6517297	6517297	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccgcctggaggcgggacctCctgcggaagaagctggaaga	16	12	0	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:6517297C>T	uc001amy.2	+	11	2547	c.2379C>T	c.(2377-2379)CTC>CTT	p.L793L	ESPN_uc001amz.2_Silent_p.L227L	NM_031475	NP_113663	B1AK53	ESPN_HUMAN	espin	793	Glu-rich.|Potential.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding				0	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		GGCGGGACCTCCTGCGGAAGA	0.642													T	6517297	T	T	6517297	2	4	56	1	0	0	0	0	0	0	0	1	5254	842	30	3		3	ESPN	1	6517297	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	4667746	6517297	242733324	2	3543											
ZNF683	257101	broad.mit.edu	37	chr1	26691247	26691247	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggaaggcagagcttggcCagaggcttggaaggcccctg	17	10	0	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:26691247C>T	uc001bmg.1	-	4	908	c.790G>A	c.(790-792)GGC>AGC	p.G264S	ZNF683_uc001bmh.1_Missense_Mutation_p.G264S|ZNF683_uc009vsj.1_Missense_Mutation_p.G264S	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		AGAGCTTGGCCAGAGGCTTGG	0.647													T	26691247	T	T	26691247	3	4	56	1	0	0	0	0	1	0	0	0	18087	594	21	3	736	3	ZNF683	1	26691247	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	20173950	26691247	222559374	3	3544											
KPNA6	23633	broad.mit.edu	37	chr1	32620313	32620317	+	Frame_Shift_Del	DEL	AGAGC	-	-													cagctccggaagcagaagcgAgagcaacaagtgagttaatg							TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:32620313_32620317delAGAGC	uc001bug.2	+	2	217_221	c.129_133delAGAGC	c.(127-135)CGAGAGCAAfs	p.R43fs	KPNA6_uc001buh.2_5'UTR|KPNA6_uc010ogx.1_Frame_Shift_Del_p.R40fs|KPNA6_uc010ogy.1_Frame_Shift_Del_p.R48fs|KPNA6_uc009vtz.2_5'Flank	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	43_45	IBB.|Nuclear localization signal (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				AGCAGAAGCGAGAGCAACAAGTGAG	0.454													-	32620317	-	-	32620313	7	5	56	1	0	1	0	1	0	0	0	0	8434	291	11	0	135	0	KPNA6	1	32620313	Frame_Shift_Del	DEL	AGAGC	TCGA-06-0649-01B-01W-0348-08	5929066	32620313	216630308	4	3545											
CSMD2	114784	broad.mit.edu	37	chr1	34209005	34209005	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgagaaggtgcccaggacGggcgcctcggcggtggcccc	17	15	0	1	rs141295499		TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:34209005G>A	uc001bxn.1	-	14	1958	c.1929C>T	c.(1927-1929)CCC>CCT	p.P643P	CSMD2_uc001bxm.1_Silent_p.P683P	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	643	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGCCCAGGACGGGCGCCTCGG	0.612													A	34209005	A	A	34209005	2	1	56	1	0	0	0	0	0	0	0	1	3945	1103	39	2		2	CSMD2	1	34209005	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	1588692	34209005	215041616	5	3546											
PTCH2	8643	broad.mit.edu	37	chr1	45307671	45307671	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agagcaggccctggaagtaaGcacgaagccagagtggagcc	15	10	0	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:45307671G>C	uc010olf.1	-	2	125	c.113C>G	c.(112-114)GCT>GGT	p.A38G	PTCH2_uc010olg.1_5'UTR	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	38	Cytoplasmic (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					CTGGAAGTAAGCACGAAGCCA	0.552									Basal_Cell_Nevus_syndrome				C	45307671	C	C	45307671	3	2	56	1	0	0	0	0	1	0	0	0	12731	971	34	5	3602	5	PTCH2	1	45307671	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	11098666	45307671	203942950	6	3547											
NBPF9	400818	broad.mit.edu	37	chr1	144615193	144615193	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaacattctagaaatcaaCgagaaattgcgcccccagtt	7	10	2	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:144615193C>T	uc009wig.1	+	3	139	c.63C>T	c.(61-63)AAC>AAT	p.N21N	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Translation_Start_Site|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Translation_Start_Site|NBPF9_uc010oyg.1_Silent_p.N21N|NBPF9_uc009wii.1_Translation_Start_Site|NBPF9_uc009wif.1_RNA|C1orf152_uc001elf.3_5'Flank	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	21						cytoplasm					0						TAGAAATCAACGAGAAATTGC	0.522													T	144615193	T	T	144615193	2	4	56	1	0	0	0	0	0	0	0	1	10199	535	19	1		1	NBPF9	1	144615193	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	99307522	144615193	104635428	7	3548											
TCHH	7062	broad.mit.edu	37	chr1	152081057	152081057	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcctgacgccgctgttgccCgcgctcctggcggcgcagct	14	17	0	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:152081057C>T	uc001ezp.2	-	2	4636	c.4636G>A	c.(4636-4638)GGG>AGG	p.G1546R	TCHH_uc009wne.1_Missense_Mutation_p.G1546R	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1546	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGCTGTTGCCCGCGCTCCTGG	0.617													T	152081057	T	T	152081057	3	4	56	1	0	0	0	0	1	0	0	0	15697	652	23	2	1199	2	TCHH	1	152081057	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	7465864	152081057	97169564	8	3549											
SLAMF8	56833	broad.mit.edu	37	chr1	159802791	159802791	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgaaataacctatagctggCgacgggagacaaccatggac	12	10	0	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:159802791C>T	uc001fue.3	+	3	703	c.493C>T	c.(493-495)CGA>TGA	p.R165*		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	165	Ig-like C2-type.|Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					CTATAGCTGGCGACGGGAGAC	0.537													T	159802791	T	T	159802791	4	4	56	1	0	0	0	0	0	1	0	0	14370	760	27	1	503	1	SLAMF8	1	159802791	Nonsense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	7721734	159802791	89447830	9	3550											
SOAT1	6646	broad.mit.edu	37	chr1	179310266	179310266	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctacattttcagttccctatTttctgtttcaacattgggcc	5	11	3	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:179310266T>G	uc001gml.2	+	7	664	c.601T>G	c.(601-603)TTT>GTT	p.F201V	SOAT1_uc010pni.1_Missense_Mutation_p.F136V|SOAT1_uc001gmm.2_Missense_Mutation_p.F143V|SOAT1_uc010pnj.1_Translation_Start_Site|SOAT1_uc010pnk.1_Missense_Mutation_p.F136V	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	201					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	AGTTCCCTATTTTCTGTTTCA	0.448													G	179310266	G	G	179310266	3	3	56	1	0	0	0	0	1	0	0	0	14910	1841	64	5	623	5	SOAT1	1	179310266	Missense_Mutation	SNP	T	TCGA-06-0649-01B-01W-0348-08	19507475	179310266	69940355	10	3551											
HMCN1	83872	broad.mit.edu	37	chr1	186088926	186088926	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaactacacgtcattctgaaCaatcctattttattaccatg	4	10	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:186088926C>T	uc001grq.1	+	79	12235	c.12006C>T	c.(12004-12006)AAC>AAT	p.N4002N		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4002	Ig-like C2-type 39.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TCATTCTGAACAATCCTATTT	0.388													T	186088926	T	T	186088926	2	4	56	1	0	0	0	0	0	0	0	1	7220	477	17	3		3	HMCN1	1	186088926	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	6778660	186088926	63161695	11	3552											
LBR	3930	broad.mit.edu	37	chr1	225598033	225598033	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacatagagaagctggaaaCtattaactaaaatcatggcc	7	9	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr1:225598033C>T	uc001hoy.2	-	10	1417	c.1274G>A	c.(1273-1275)AGT>AAT	p.S425N	LBR_uc001hoz.2_Missense_Mutation_p.S425N|LBR_uc001hpa.1_Missense_Mutation_p.S425N	NM_002296	NP_002287	Q14739	LBR_HUMAN	lamin B receptor	425					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		AAGCTGGAAACTATTAACTAA	0.443													T	225598033	T	T	225598033	3	4	56	1	0	0	0	0	1	0	0	0	8652	565	20	3	593	3	LBR	1	225598033	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	39509107	225598033	23652588	12	3553											
CRIM1	51232	broad.mit.edu	37	chr2	36740894	36740894	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattcaccctggacagtgctGcccatcatgtgcaggtaaaa	9	12	2	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr2:36740894G>A	uc002rpd.2	+	11	2015	c.1976G>A	c.(1975-1977)TGC>TAC	p.C659Y		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	659	VWFC 3.|Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				GGACAGTGCTGCCCATCATGT	0.388													A	36740894	A	A	36740894	3	1	56	1	0	0	0	0	1	0	0	0	3873	1319	46	3	2018	3	CRIM1	2	36740894	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08		36740894	206458479	13	3554											
ZNF638	27332	broad.mit.edu	37	chr2	71592818	71592818	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaacaggtgtctgataaagcTgtttctctccagcgaaaggt	10	8	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr2:71592818T>G	uc002shx.2	+	6	2296	c.1977T>G	c.(1975-1977)GCT>GCG	p.A659A	ZNF638_uc010fec.2_Silent_p.A765A|ZNF638_uc010yqw.1_Silent_p.A238A|ZNF638_uc002shw.2_Silent_p.A659A|ZNF638_uc002shy.2_Silent_p.A659A|ZNF638_uc002shz.2_Silent_p.A659A|ZNF638_uc002sia.2_Silent_p.A659A|ZNF638_uc002sib.1_Silent_p.A659A|ZNF638_uc010fed.2_RNA	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	659					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						CTGATAAAGCTGTTTCTCTCC	0.229													G	71592818	G	G	71592818	2	3	56	1	0	0	0	0	0	0	0	1	18052	1567	55	5		5	ZNF638	2	71592818	Silent	SNP	T	TCGA-06-0649-01B-01W-0348-08	34851924	71592818	171606555	14	3555											
SLC9A2	6549	broad.mit.edu	37	chr2	103324656	103324656	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagagccaggcgcttcttgcCagaacagttctccaagaaat	9	12	2	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr2:103324656C>A	uc002tca.2	+	12	2289	c.2147C>A	c.(2146-2148)CCA>CAA	p.P716Q		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	716	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						CGCTTCTTGCCAGAACAGTTC	0.527													A	103324656	A	A	103324656	3	1	56	1	0	0	0	0	1	0	0	0	14712	594	21	5	2193	5	SLC9A2	2	103324656	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	31731838	103324656	139874717	15	3556											
UGGT1	56886	broad.mit.edu	37	chr2	128867271	128867271	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttcagtgcatggaaagaagActtgtgaatctgataccctt	9	7	2	4			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr2:128867271A>G	uc002tps.2	+	5	650	c.472A>G	c.(472-474)ACT>GCT	p.T158A	UGGT1_uc010fme.1_Missense_Mutation_p.T33A|UGGT1_uc002tpr.2_Missense_Mutation_p.T134A	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	158					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TGGAAAGAAGACTTGTGAATC	0.388													G	128867271	G	G	128867271	3	3	56	1	0	0	0	0	1	0	0	0	16938	275	10	4	490	4	UGGT1	2	128867271	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	25542615	128867271	114332102	16	3557											
TTN	7273	broad.mit.edu	37	chr2	179641950	179641950	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgtcagggttggggttaccCgtagctctgactttcatttc	11	9	3	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr2:179641950C>A	uc010zfg.1	-	27	4964	c.4740G>T	c.(4738-4740)ACG>ACT	p.T1580T	TTN_uc010zfh.1_Silent_p.T1534T|TTN_uc010zfi.1_Silent_p.T1534T|TTN_uc010zfj.1_Silent_p.T1534T|TTN_uc002unb.2_Silent_p.T1580T|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1580							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGGGTTACCCGTAGCTCTGA	0.373													A	179641950	A	A	179641950	2	1	56	1	0	0	0	0	0	0	0	1	16732	639	23	5		5	TTN	2	179641950	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	50774679	179641950	63557423	17	3558											
PTH2R	5746	broad.mit.edu	37	chr2	209308179	209308179	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gagtagtccatgctcacataGgagtaaaggagctggagtcc	13	8	1	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr2:209308179G>C	uc002vdb.2	+	6	829	c.616G>C	c.(616-618)GGA>CGA	p.G206R	PTH2R_uc010zjb.1_Missense_Mutation_p.G217R	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	206	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TGCTCACATAGGAGTAAAGGA	0.413													C	209308179	C	C	209308179	3	2	56	1	0	0	0	0	1	0	0	0	12760	1001	35	5	638	5	PTH2R	2	209308179	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	29666229	209308179	33891194	18	3559											
TRPM8	79054	broad.mit.edu	37	chr2	234869493	234869493	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtttgtccgcctctttctggAgaatggcttgaacctacgga	11	10	2	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr2:234869493A>G	uc002vvh.2	+	12	1476	c.1436A>G	c.(1435-1437)GAG>GGG	p.E479G	TRPM8_uc010fyj.2_Missense_Mutation_p.E167G	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	479	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTCTTTCTGGAGAATGGCTTG	0.483													G	234869493	G	G	234869493	3	3	56	1	0	0	0	0	1	0	0	0	16589	304	11	4	1478	4	TRPM8	2	234869493	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	25561314	234869493	8329880	19	3560											
COL6A3	1293	broad.mit.edu	37	chr2	238283454	238283454	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagggtcagctggcggacagCgttgacgacgtcctgcttgt	15	11	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr2:238283454C>T	uc002vwl.2	-	8	3565	c.3280G>A	c.(3280-3282)GCT>ACT	p.A1094T	COL6A3_uc002vwo.2_Missense_Mutation_p.A888T|COL6A3_uc010znj.1_Missense_Mutation_p.A487T|COL6A3_uc002vwq.2_Missense_Mutation_p.A888T|COL6A3_uc002vwr.2_Missense_Mutation_p.A687T	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1094	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGGCGGACAGCGTTGACGACG	0.652													T	238283454	T	T	238283454	3	4	56	1	0	0	0	0	1	0	0	0	3701	768	27	1	6448	1	COL6A3	2	238283454	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	3413961	238283454	4915919	20	3561											
TGFBR2	7048	broad.mit.edu	37	chr3	30691812	30691812	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gacagtttgccatgaccccaAgctcccctaccatgacttta	6	15	0	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr3:30691812A>T	uc003ceo.2	+	3	696	c.314A>T	c.(313-315)AAG>ATG	p.K105M	TGFBR2_uc003cen.2_Missense_Mutation_p.K130M	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	105	Extracellular (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CATGACCCCAAGCTCCCCTAC	0.443													T	30691812	T	T	30691812	3	4	56	1	0	0	0	0	1	0	0	0	15819	72	3	5	403	5	TGFBR2	3	30691812	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08		30691812	167330618	21	3562											
KBTBD5	131377	broad.mit.edu	37	chr3	42729720	42729720	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggagaagctctcaactcCatctacgtggtcggtggcag	13	11	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr3:42729720C>T	uc003clv.1	+	2	1339	c.1239C>T	c.(1237-1239)TCC>TCT	p.S413S		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	413	Kelch 2.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CTCTCAACTCCATCTACGTGG	0.637													T	42729720	T	T	42729720	2	4	56	1	0	0	0	0	0	0	0	1	7996	581	21	3		3	KBTBD5	3	42729720	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	12037908	42729720	155292710	22	3563											
MORC1	27136	broad.mit.edu	37	chr3	108819325	108819325	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgacagccgttttttggatcGtccaaagtaaatgatgtctg	10	7	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr3:108819325G>T	uc003dxl.2	-	5	340	c.253C>A	c.(253-255)CGA>AGA	p.R85R	MORC1_uc011bhn.1_Silent_p.R85R	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	85					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TTTTTGGATCGTCCAAAGTAA	0.408													T	108819325	T	T	108819325	2	4	56	1	0	0	0	0	0	0	0	1	9701	1153	40	5		5	MORC1	3	108819325	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	66089605	108819325	89203105	23	3564											
RFC4	5984	broad.mit.edu	37	chr3	186508171	186508173	+	In_Frame_Del	DEL	CAT	-	-													ctgacaggcagcaaatactcCatcaattttctcagctggta							TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr3:186508171_186508173delCAT	uc003fqz.2	-	9	1047_1049	c.824_826delATG	c.(823-828)GATGGA>GGA	p.D275del	RFC4_uc011bsc.1_In_Frame_Del_p.D275del	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	275					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		GCAAATACTCCATCAATTTTCTC	0.424													-	186508173	-	-	186508171	7	5	56	1	0	1	0	1	0	0	0	0	13247	603	21	0	277	0	RFC4	3	186508171	In_Frame_Del	DEL	CAT	TCGA-06-0649-01B-01W-0348-08	77688846	186508171	11514259	24	3565											
FBXL5	26234	broad.mit.edu	37	chr4	15632339	15632339	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actcatgaaaagcacgacttTcatctttcctatttttcacc	3	12	4	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr4:15632339T>G	uc003goc.1	-	6	945	c.842A>C	c.(841-843)GAA>GCA	p.E281A	FBXL5_uc010idw.1_Missense_Mutation_p.E194A|FBXL5_uc003gob.1_Missense_Mutation_p.E155A|FBXL5_uc010idx.1_Missense_Mutation_p.E280A|FBXL5_uc003god.1_Missense_Mutation_p.E264A|FBXL5_uc010idy.1_Missense_Mutation_p.E281A	NM_012161	NP_036293	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5 isoform	281					iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0						AGCACGACTTTCATCTTTCCT	0.343													G	15632339	G	G	15632339	3	3	56	1	0	0	0	0	1	0	0	0	5722	1783	62	5	1257	5	FBXL5	4	15632339	Missense_Mutation	SNP	T	TCGA-06-0649-01B-01W-0348-08		15632339	175521937	25	3566											
CLOCK	9575	broad.mit.edu	37	chr4	56336906	56336906	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtaaatgttcaagtaatgaaGttacactctcagacacatat	6	7	2	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr4:56336906G>T	uc003haz.1	-	9	1342	c.416C>A	c.(415-417)ACT>AAT	p.T139N	CLOCK_uc003hba.1_Missense_Mutation_p.T139N	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	139	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			AAGTAATGAAGTTACACTCTC	0.299													T	56336906	T	T	56336906	3	4	56	1	0	0	0	0	1	0	0	0	3549	1029	36	5	2188	5	CLOCK	4	56336906	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	40704567	56336906	134817370	26	3567											
UGT2B7	7364	broad.mit.edu	37	chr4	69962642	69962642	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agatgtagtttcaaataagaAatttatgaaaaaagtacaag	7	2	1	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr4:69962642A>T	uc003heg.3	+	1	450	c.404A>T	c.(403-405)AAA>ATA	p.K135I	UGT2B7_uc010ihq.2_Missense_Mutation_p.K135I	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	135					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TCAAATAAGAAATTTATGAAA	0.313													T	69962642	T	T	69962642	3	4	56	1	0	0	0	0	1	0	0	0	16959	14	1	5	406	5	UGT2B7	4	69962642	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	13625736	69962642	121191634	27	3568											
UGT2B4	7363	broad.mit.edu	37	chr4	70351106	70351106	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgcctcatagatgccattgGctccaccatgagttataaaa	7	10	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr4:70351106G>T	uc003hek.3	-	5	1177	c.1130C>A	c.(1129-1131)GCC>GAC	p.A377D	UGT2B4_uc011cap.1_Missense_Mutation_p.A241D|UGT2B4_uc003hel.3_Intron	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	377					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						GATGCCATTGGCTCCACCATG	0.413													T	70351106	T	T	70351106	3	4	56	1	0	0	0	0	1	0	0	0	16958	1203	42	5	464	5	UGT2B4	4	70351106	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	388464	70351106	120803170	28	3569											
ANK2	287	broad.mit.edu	37	chr4	114274747	114274747	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caaagagcagctgcagacagTtcaagataaggcagggaaga	13	7	1	4			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr4:114274747T>C	uc003ibe.3	+	38	5073	c.4973T>C	c.(4972-4974)GTT>GCT	p.V1658A	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.V1673A	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1625					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGCAGACAGTTCAAGATAAG	0.473													C	114274747	C	C	114274747	3	2	56	1	0	0	0	0	1	0	0	0	621	1725	60	4	5188	4	ANK2	4	114274747	Missense_Mutation	SNP	T	TCGA-06-0649-01B-01W-0348-08	43923641	114274747	76879529	29	3570											
CTNND2	1501	broad.mit.edu	37	chr5	11236806	11236806	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccaaggagcactgacctcGgctttaattttgttgtctcc	8	11	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr5:11236806G>A	uc003jfa.1	-	10	1903	c.1758C>T	c.(1756-1758)GCC>GCT	p.A586A	CTNND2_uc010itt.2_Silent_p.A495A|CTNND2_uc011cmy.1_Silent_p.A249A|CTNND2_uc011cmz.1_Silent_p.A153A|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.A153A	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	586	ARM 3.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CACTGACCTCGGCTTTAATTT	0.443													A	11236806	A	A	11236806	2	1	56	1	0	0	0	0	0	0	0	1	4020	1103	39	2		2	CTNND2	5	11236806	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08		11236806	169678454	30	3571											
SLIT3	6586	broad.mit.edu	37	chr5	168098222	168098222	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctgtggccgaggcaggggtCccgggcctcctgatcgcaga	16	14	0	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr5:168098222C>T	uc003mab.2	-	34	4528	c.4108G>A	c.(4108-4110)GAC>AAC	p.D1370N	SLIT3_uc010jjg.2_Missense_Mutation_p.D1377N	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1370	EGF-like 8.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGCAGGGGTCCCGGGCCTCC	0.672													T	168098222	T	T	168098222	3	4	56	1	0	0	0	0	1	0	0	0	14741	855	30	3	475	3	SLIT3	5	168098222	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	156861416	168098222	12817038	31	3572											
KIF13A	63971	broad.mit.edu	37	chr6	17826293	17826293	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaagtgattatttccccatAggattcggtcaccatgccac	7	11	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr6:17826293A>G	uc003ncg.3	-	15	1700	c.1595T>C	c.(1594-1596)CTA>CCA	p.L532P	KIF13A_uc003ncf.2_Missense_Mutation_p.L532P|KIF13A_uc003nch.3_Missense_Mutation_p.L532P|KIF13A_uc003nci.3_Missense_Mutation_p.L532P|KIF13A_uc003ncj.2_Missense_Mutation_p.L208P	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	532					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			ATTTCCCCATAGGATTCGGTC	0.398													G	17826293	G	G	17826293	3	3	56	1	0	0	0	0	1	0	0	0	8274	420	15	4	3947	4	KIF13A	6	17826293	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08		17826293	153288774	32	3573											
OR2B3	442184	broad.mit.edu	37	chr6	29054831	29054831	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cagagatctaagatggagagAttagtgagaaagaaatacat	11	3	1	5			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr6:29054831A>T	uc003nlx.2	-	1	260	c.195T>A	c.(193-195)AAT>AAA	p.N65K		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						AGATGGAGAGATTAGTGAGAA	0.398													T	29054831	T	T	29054831	3	4	56	1	0	0	0	0	1	0	0	0	10990	330	12	5	750	5	OR2B3	6	29054831	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	11228538	29054831	142060236	33	3574											
BTNL2	56244	broad.mit.edu	37	chr6	32372722	32372722	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccagatattcacctgctaCtttgagcagcaagcttgttt	7	12	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr6:32372722C>T	uc003obg.1	-	2	421	c.421G>A	c.(421-423)GTA>ATA	p.V141I	BTNL2_uc010jty.1_Intron|BTNL2_uc010jtz.1_Intron|BTNL2_uc010jua.1_Intron	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	141	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						TCACCTGCTACTTTGAGCAGC	0.448													T	32372722	T	T	32372722	3	4	56	1	0	0	0	0	1	0	0	0	1565	565	20	3	966	3	BTNL2	6	32372722	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	3317891	32372722	138742345	34	3575											
CGA	1081	broad.mit.edu	37	chr6	87796012	87796012	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaagtggactctgaggtgaCgttcttttggaccaacatcg	12	9	2	2	rs145503313		TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr6:87796012C>T	uc003plj.1	-	3	330	c.229G>A	c.(229-231)GTC>ATC	p.V77I		NM_000735	NP_000726	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	77					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			ovary(1)	1		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		TCTGAGGTGACGTTCTTTTGG	0.483													T	87796012	T	T	87796012	3	4	56	1	0	0	0	0	1	0	0	0	3295	536	19	1	129	1	CGA	6	87796012	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	55423290	87796012	83319055	35	3576											
LAMA2	3908	broad.mit.edu	37	chr6	129813614	129813614	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcctttcctacgcccaccCcagttctgacacatgtaagt	6	16	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr6:129813614C>T	uc003qbn.2	+	57	8335	c.8230C>T	c.(8230-8232)CCA>TCA	p.P2744S	LAMA2_uc003qbo.2_Missense_Mutation_p.P2740S|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2744					cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TACGCCCACCCCAGTTCTGAC	0.443													T	129813614	T	T	129813614	3	4	56	1	0	0	0	0	1	0	0	0	8606	623	22	3	8460	3	LAMA2	6	129813614	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	42017602	129813614	41301453	36	3577											
PLG	5340	broad.mit.edu	37	chr6	161127532	161127532	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggagcaggaagtatagaagAatgtgcagcaaaatgtgagg	16	3	0	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr6:161127532A>G	uc003qtm.3	+	2	206	c.143A>G	c.(142-144)GAA>GGA	p.E48G		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	48	PAN.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AGTATAGAAGAATGTGCAGCA	0.468													G	161127532	G	G	161127532	3	3	56	1	0	0	0	0	1	0	0	0	12086	246	9	4	149	4	PLG	6	161127532	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	31313918	161127532	9987535	37	3578											
C7orf41	222166	broad.mit.edu	37	chr7	30174862	30174862	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatggatttctacgccgaccCcggcgtctccttctatgtgc	10	14	3	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:30174862C>T	uc011kab.1	+	1	311	c.110C>T	c.(109-111)CCC>CTC	p.P37L	C7orf41_uc010kvr.1_RNA|C7orf41_uc003tar.1_Missense_Mutation_p.P37L	NM_152793	NP_690006	Q8N3F0	CG041_HUMAN	hypothetical protein LOC222166	37											0						TACGCCGACCCCGGCGTCTCC	0.642													T	30174862	T	T	30174862	3	4	56	1	0	0	0	0	1	0	0	0	2391	623	22	3	112	3	C7orf41	7	30174862	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08		30174862	128963801	38	3579											
PDE1C	5137	broad.mit.edu	37	chr7	31855588	31855588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggctttggagtttttcccaCgagggttgtcacttttgttt	11	8	1	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:31855588C>T	uc003tcm.1	-	15	2232	c.1763G>A	c.(1762-1764)CGT>CAT	p.R588H	PDE1C_uc003tcn.1_Missense_Mutation_p.R588H|PDE1C_uc003tco.1_Missense_Mutation_p.R648H|PDE1C_uc003tcr.2_Missense_Mutation_p.R588H|PDE1C_uc003tcs.2_Missense_Mutation_p.R588H	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	588					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			GTTTTTCCCACGAGGGTTGTC	0.468													T	31855588	T	T	31855588	3	4	56	1	0	0	0	0	1	0	0	0	11635	536	19	1	153	1	PDE1C	7	31855588	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	1680726	31855588	127283075	39	3580											
C7orf10	79783	broad.mit.edu	37	chr7	40228112	40228112	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggagctggtgatgatacacGaacttgggggccaccttttg	14	8	0	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:40228112G>A	uc003thn.1	+	4	290	c.245G>A	c.(244-246)CGA>CAA	p.R82Q	C7orf10_uc003thm.1_Missense_Mutation_p.R89Q|C7orf10_uc003tho.1_Missense_Mutation_p.R82Q	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	89							transferase activity			ovary(2)	2						GATGATACACGAACTTGGGGG	0.279													A	40228112	A	A	40228112	3	1	56	1	0	0	0	0	1	0	0	0	2376	1058	37	2	280	2	C7orf10	7	40228112	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	8372524	40228112	118910551	40	3581											
EGFR	1956	broad.mit.edu	37	chr7	55223624	55223624	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaagtgtaagaagtgcgaaGggccttgccgcaaaggtagg	16	7	0	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:55223624G>A	uc003tqk.2	+	8	1237	c.991G>A	c.(991-993)GGG>AGG	p.G331R	EGFR_uc003tqh.2_Missense_Mutation_p.G331R|EGFR_uc003tqi.2_Missense_Mutation_p.G331R|EGFR_uc003tqj.2_Missense_Mutation_p.G331R|EGFR_uc010kzg.1_Missense_Mutation_p.G286R|EGFR_uc011kco.1_Missense_Mutation_p.G278R|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	331	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAAGTGCGAAGGGCCTTGCCG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55223624	A	A	55223624	3	1	56	1	0	0	0	0	1	0	0	0	4967	1000	35	3	1021	3	EGFR	7	55223624	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	14995512	55223624	103915039	41	3582											
WBSCR17	64409	broad.mit.edu	37	chr7	71130459	71130459	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gggtggcccacattgagcggAagaagaagccatataatagc	13	8	0	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:71130459A>T	uc003tvy.2	+	7	1144	c.1144A>T	c.(1144-1146)AAG>TAG	p.K382*	WBSCR17_uc003tvz.2_Nonsense_Mutation_p.K81*	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	382	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CATTGAGCGGAAGAAGAAGCC	0.488													T	71130459	T	T	71130459	4	4	56	1	0	0	0	0	0	1	0	0	17261	247	9	5	1170	5	WBSCR17	7	71130459	Nonsense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	15906835	71130459	88008204	42	3583											
MLXIPL	51085	broad.mit.edu	37	chr7	73011056	73011056	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccgggcctggaggtggccGgggcggtgtaggggccgggg	26	9	0	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:73011056G>A	uc003tyn.1	-	11	1783	c.1735C>T	c.(1735-1737)CGG>TGG	p.R579W	MLXIPL_uc003tyj.1_Intron|MLXIPL_uc003tyk.1_Missense_Mutation_p.R579W|MLXIPL_uc003tyl.1_Missense_Mutation_p.R579W|MLXIPL_uc003tym.1_Missense_Mutation_p.R579W|MLXIPL_uc003tyo.1_Intron|MLXIPL_uc003typ.1_Missense_Mutation_p.R485W|MLXIPL_uc003tyq.1_Missense_Mutation_p.R346W	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	579					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				GGAGGTGGCCGGGGCGGTGTA	0.692													A	73011056	A	A	73011056	3	1	56	1	0	0	0	0	1	0	0	0	9637	1115	39	2	851	2	MLXIPL	7	73011056	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	1880597	73011056	86127607	43	3584											
SEMA3C	10512	broad.mit.edu	37	chr7	80390932	80390932	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taaaatagcttagtttttacCtttttagatgaaattttcat	4	4	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:80390932C>A	uc003uhj.2	-	14	2047	c.1485G>T	c.(1483-1485)AAG>AAT	p.K495N	SEMA3C_uc011kgw.1_Missense_Mutation_p.K513N	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	495	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						TAGTTTTTACCTTTTTAGATG	0.229													A	80390932	A	A	80390932	3	1	56	1	0	0	0	0	1	0	0	0	14026	695	24	5	790	5	SEMA3C	7	80390932	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	7379876	80390932	78747731	44	3585											
PCLO	27445	broad.mit.edu	37	chr7	82581469	82581469	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacacagctcttctccctgCggttaaatcaacgggttttt	8	12	3	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:82581469C>T	uc003uhx.2	-	5	9089	c.8800G>A	c.(8800-8802)GCA>ACA	p.A2934T	PCLO_uc003uhv.2_Missense_Mutation_p.A2934T|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2865					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTTCTCCCTGCGGTTAAATCA	0.433													T	82581469	T	T	82581469	3	4	56	1	0	0	0	0	1	0	0	0	11583	768	27	1	6729	1	PCLO	7	82581469	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	2190537	82581469	76557194	45	3586											
SAMD9L	219285	broad.mit.edu	37	chr7	92761300	92761300	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagagcttctagctttttccTgcaattctcctcctggagta	7	12	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:92761300T>C	uc003umh.1	-	5	5201	c.3985A>G	c.(3985-3987)AGG>GGG	p.R1329G	SAMD9L_uc003umj.1_Missense_Mutation_p.R1329G|SAMD9L_uc003umi.1_Missense_Mutation_p.R1329G|SAMD9L_uc010lfb.1_Missense_Mutation_p.R1329G|SAMD9L_uc003umk.1_Missense_Mutation_p.R1329G|SAMD9L_uc010lfc.1_Missense_Mutation_p.R1329G|SAMD9L_uc010lfd.1_Missense_Mutation_p.R1329G|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1329										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGCTTTTTCCTGCAATTCTCC	0.388													C	92761300	C	C	92761300	3	2	56	1	0	0	0	0	1	0	0	0	13827	1579	55	4	773	4	SAMD9L	7	92761300	Missense_Mutation	SNP	T	TCGA-06-0649-01B-01W-0348-08	10179831	92761300	66377363	46	3587											
HEPACAM2	253012	broad.mit.edu	37	chr7	92848596	92848596	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gaaccacagacttattcacaGagcccagtaagtatttgggc	9	10	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:92848596G>A	uc003umm.2	-	2	271	c.248C>T	c.(247-249)TCT>TTT	p.S83F	HEPACAM2_uc003uml.2_Missense_Mutation_p.S71F|HEPACAM2_uc010lff.2_Missense_Mutation_p.S71F|HEPACAM2_uc011khy.1_Missense_Mutation_p.S106F	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	83	Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						CTTATTCACAGAGCCCAGTAA	0.478													A	92848596	A	A	92848596	3	1	56	1	0	0	0	0	1	0	0	0	7053	942	33	3	1176	3	HEPACAM2	7	92848596	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	87296	92848596	66290067	47	3588											
NPTX2	4885	broad.mit.edu	37	chr7	98254367	98254367	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcctgtggctgcggtccagCgcctcaccaggcattggcac	13	15	1	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:98254367C>T	uc003upl.2	+	3	954	c.777C>T	c.(775-777)AGC>AGT	p.S259S		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	259	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			TGCGGTCCAGCGCCTCACCAG	0.607													T	98254367	T	T	98254367	2	4	56	1	0	0	0	0	0	0	0	1	10603	767	27	1		1	NPTX2	7	98254367	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	5405771	98254367	60884296	48	3589											
LAMB4	22798	broad.mit.edu	37	chr7	107720190	107720190	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaggaactggctctcctaaAacaacgtgaacagcaggact	9	12	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:107720190A>C	uc010ljo.1	-	15	1827	c.1743T>G	c.(1741-1743)GTT>GTG	p.V581V	LAMB4_uc003vey.2_Silent_p.V581V	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	581	Laminin IV type B.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						GCTCTCCTAAAACAACGTGAA	0.502													C	107720190	C	C	107720190	2	2	56	1	0	0	0	0	0	0	0	1	8613	1	1	5		5	LAMB4	7	107720190	Silent	SNP	A	TCGA-06-0649-01B-01W-0348-08	9465823	107720190	51418473	49	3590											
EPHA1	2041	broad.mit.edu	37	chr7	143095767	143095767	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agccctgacactccattttgGgcttccacattaaaggtgta	8	11	0	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:143095767G>C	uc003wcz.2	-	6	1350	c.1263C>G	c.(1261-1263)GCC>GCG	p.A421A		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	421	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CTCCATTTTGGGCTTCCACAT	0.607													C	143095767	C	C	143095767	2	2	56	1	0	0	0	0	0	0	0	1	5165	1219	43	5		5	EPHA1	7	143095767	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	35375577	143095767	16042896	50	3591											
GIMAP4	55303	broad.mit.edu	37	chr7	150269791	150269791	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgctgggcctgatccagcgCgtggtgagggagaacaagga	17	8	0	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr7:150269791C>T	uc003whl.2	+	3	715	c.633C>T	c.(631-633)CGC>CGT	p.R211R	GIMAP4_uc011kuu.1_Silent_p.R72R|GIMAP4_uc011kuv.1_Silent_p.R225R	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	211	Potential.						GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGATCCAGCGCGTGGTGAGGG	0.542													T	150269791	T	T	150269791	2	4	56	1	0	0	0	0	0	0	0	1	6381	755	27	1		1	GIMAP4	7	150269791	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	7174024	150269791	8868872	51	3592											
KCNU1	157855	broad.mit.edu	37	chr8	36693858	36693858	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttctaccaccagaatcatcaTacagatactgcaatcccata	3	13	3	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr8:36693858T>A	uc010lvw.2	+	13	1427	c.1340T>A	c.(1339-1341)ATA>AAA	p.I447K	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	447	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AGAATCATCATACAGATACTG	0.358													A	36693858	A	A	36693858	3	1	56	1	0	0	0	0	1	0	0	0	8093	1406	49	5	1390	5	KCNU1	8	36693858	Missense_Mutation	SNP	T	TCGA-06-0649-01B-01W-0348-08		36693858	109670164	52	3593											
TMEM70	54968	broad.mit.edu	37	chr8	74893724	74893724	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acattttatgctaaaacaaaAtcactgttagttaatccagt	4	7	1	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr8:74893724A>C	uc003yab.2	+	3	738	c.651A>C	c.(649-651)AAA>AAC	p.K217N	TMEM70_uc003yac.2_3'UTR	NM_017866	NP_060336	Q9BUB7	TMM70_HUMAN	transmembrane protein 70 isoform a	217					mitochondrial proton-transporting ATP synthase complex assembly	integral to mitochondrial membrane|mitochondrial inner membrane				ovary(1)	1	Breast(64;0.0311)		Epithelial(68;0.0186)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0564)			CTAAAACAAAATCACTGTTAG	0.343													C	74893724	C	C	74893724	3	2	56	1	0	0	0	0	1	0	0	0	16196	98	4	5	669	5	TMEM70	8	74893724	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	38199866	74893724	71470298	53	3594											
KIAA0196	9897	broad.mit.edu	37	chr8	126056120	126056120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctgtgttttggcaatggCggaaaaataaattttatttg	9	4	1	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr8:126056120C>T	uc003yrt.2	-	23	3126	c.2797G>A	c.(2797-2799)GCC>ACC	p.A933T	KIAA0196_uc011lir.1_Missense_Mutation_p.A785T|KIAA0196_uc003yru.1_Missense_Mutation_p.A507T	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	933					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TTGGCAATGGCGGAAAAATAA	0.353													T	126056120	T	T	126056120	3	4	56	1	0	0	0	0	1	0	0	0	8161	768	27	1	710	1	KIAA0196	8	126056120	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	51162396	126056120	20307902	54	3595											
GPR20	2843	broad.mit.edu	37	chr8	142367229	142367229	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgtggcatgtcgggccacagCgccacggccacttggcgggc	16	14	0	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr8:142367229C>A	uc003ywf.2	-	2	884	c.795G>T	c.(793-795)GCG>GCT	p.A265A		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	265	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CGGGCCACAGCGCCACGGCCA	0.657													A	142367229	A	A	142367229	2	1	56	1	0	0	0	0	0	0	0	1	6680	755	27	5		5	GPR20	8	142367229	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	16311109	142367229	3996793	55	3596											
SMARCA2	6595	broad.mit.edu	37	chr9	2104169	2104169	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctttacctacgccttgatGgtaagtgcataaggcattag	9	9	0	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr9:2104169G>A	uc003zhc.2	+	23	3391	c.3292G>A	c.(3292-3294)GGC>AGC	p.G1098S	SMARCA2_uc003zhd.2_Missense_Mutation_p.G1098S|SMARCA2_uc010mha.2_Missense_Mutation_p.G1031S	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1098	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ACGCCTTGATGGTAAGTGCAT	0.438													A	2104169	A	A	2104169	3	1	56	1	0	0	0	0	1	0	0	0	14769	1362	47	3	3378	3	SMARCA2	9	2104169	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08		2104169	139109262	56	3597											
KIAA2026	158358	broad.mit.edu	37	chr9	5944873	5944874	+	Frame_Shift_Ins	INS	-	T	T													tttggatcaacacctaccgaINStttttttctactgttttcca							TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr9:5944873_5944874insT	uc003zjq.3	-	5	2595_2596	c.2379_2380insA	c.(2377-2382)AAATCGfs	p.K793fs	KIAA2026_uc010mht.2_Intron	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	793_794										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		ACACCTACCGATTTTTTTCTAC	0.307													T	5944874	T	T	5944873	7	5	56	1	0	1	1	0	0	0	0	0	8270	333	12	0	3947	0	KIAA2026	9	5944873	Frame_Shift_Ins	INS	-	TCGA-06-0649-01B-01W-0348-08	3840704	5944873	135268558	57	3598											
TRPM3	80036	broad.mit.edu	37	chr9	73152156	73152156	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaggtcctcgagcggattttGttggactcggcccgctccag	14	12	0	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr9:73152156G>T	uc004aid.2	-	25	4081	c.3837C>A	c.(3835-3837)AAC>AAA	p.N1279K	TRPM3_uc004ahu.2_Missense_Mutation_p.N1121K|TRPM3_uc004ahv.2_Missense_Mutation_p.N1081K|TRPM3_uc004ahw.2_Missense_Mutation_p.N1151K|TRPM3_uc004ahx.2_Missense_Mutation_p.N1138K|TRPM3_uc004ahy.2_Missense_Mutation_p.N1141K|TRPM3_uc004ahz.2_Missense_Mutation_p.N1128K|TRPM3_uc004aia.2_Missense_Mutation_p.N1126K|TRPM3_uc004aib.2_Missense_Mutation_p.N1116K|TRPM3_uc004aic.2_Missense_Mutation_p.N1279K	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1304	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AGCGGATTTTGTTGGACTCGG	0.627													T	73152156	T	T	73152156	3	4	56	1	0	0	0	0	1	0	0	0	16584	1368	48	5	1290	5	TRPM3	9	73152156	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	67207283	73152156	68061275	58	3599											
TRPM6	140803	broad.mit.edu	37	chr9	77377948	77377948	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccacagtcagggcagagagAtcctgcaggtgtcccacctg	12	13	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr9:77377948A>G	uc004ajl.1	-	26	3877	c.3639T>C	c.(3637-3639)GAT>GAC	p.D1213D	TRPM6_uc004ajk.1_Silent_p.D1208D|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Silent_p.D169D	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1213	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GGGCAGAGAGATCCTGCAGGT	0.463													G	77377948	G	G	77377948	2	3	56	1	0	0	0	0	0	0	0	1	16587	330	12	4		4	TRPM6	9	77377948	Silent	SNP	A	TCGA-06-0649-01B-01W-0348-08	4225792	77377948	63835483	59	3600											
TTC16	158248	broad.mit.edu	37	chr9	130489287	130489287	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aacctcttcccgggcatgtcGgtggaggaggtgcttagcac	14	11	1	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr9:130489287G>T	uc004brq.1	+	11	1531	c.1464G>T	c.(1462-1464)TCG>TCT	p.S488S	PTRH1_uc011mah.1_5'Flank|TTC16_uc011mai.1_Silent_p.S475S|TTC16_uc004brr.1_Intron|TTC16_uc010mxn.1_Silent_p.S84S	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	488							binding				0						CGGGCATGTCGGTGGAGGAGG	0.642													T	130489287	T	T	130489287	2	4	56	1	0	0	0	0	0	0	0	1	16680	1103	39	5		5	TTC16	9	130489287	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	53111339	130489287	10724144	60	3601											
RXRA	6256	broad.mit.edu	37	chr9	137309139	137309139	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggagcccaagaccgagacctAcgtggaggcaaacatggggc	15	11	0	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr9:137309139A>T	uc004cfb.2	+	5	908	c.746A>T	c.(745-747)TAC>TTC	p.Y249F	RXRA_uc004cfc.1_Missense_Mutation_p.Y152F|RXRA_uc004cfd.1_Missense_Mutation_p.Y20F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	249	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	ACCGAGACCTACGTGGAGGCA	0.622													T	137309139	T	T	137309139	3	4	56	1	0	0	0	0	1	0	0	0	13763	391	14	5	764	5	RXRA	9	137309139	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	6819852	137309139	3904292	61	3602											
ERCC6	2074	broad.mit.edu	37	chr10	50667268	50667268	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attatcttttccctccttttTcatgatgccatcctataaaa	2	11	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr10:50667268T>C	uc001jhs.3	-	21	4229	c.4075A>G	c.(4075-4077)AAA>GAA	p.K1359E	ERCC6_uc009xod.2_Missense_Mutation_p.K519E|ERCC6_uc010qgr.1_Missense_Mutation_p.K729E|ERCC6_uc001jhr.3_Missense_Mutation_p.K727E	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1359					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						CCCTCCTTTTTCATGATGCCA	0.443								Direct_reversal_of_damage|NER					C	50667268	C	C	50667268	3	2	56	1	0	0	0	0	1	0	0	0	5217	1792	62	4	410	4	ERCC6	10	50667268	Missense_Mutation	SNP	T	TCGA-06-0649-01B-01W-0348-08		50667268	84867479	62	3603											
PCDH15	65217	broad.mit.edu	37	chr10	55582616	55582616	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcttcagttgtaagcaatgGattgctgctacctcttttgt	8	9	3	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr10:55582616G>A	uc001jju.1	-	33	5265	c.4870C>T	c.(4870-4872)CCA>TCA	p.P1624S	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.P1621S|PCDH15_uc010qhw.1_Missense_Mutation_p.P1584S|PCDH15_uc010qhx.1_Missense_Mutation_p.P1555S|PCDH15_uc010qhy.1_Missense_Mutation_p.P1631S|PCDH15_uc010qhz.1_Missense_Mutation_p.P1626S|PCDH15_uc010qia.1_Missense_Mutation_p.P1604S|PCDH15_uc010qib.1_Missense_Mutation_p.P1601S	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1624	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GTAAGCAATGGATTGCTGCTA	0.418										HNSCC(58;0.16)			A	55582616	A	A	55582616	3	1	56	1	0	0	0	0	1	0	0	0	11511	1174	41	3	2607	3	PCDH15	10	55582616	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	4915348	55582616	79952131	63	3604											
PTEN	5728	broad.mit.edu	37	chr10	89692904	89692904	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actgtaaagctggaaagggaCgaactggtgtaatgatatgt	13	4	0	1	rs121909224		TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr10:89692904C>G	uc001kfb.2	+	6	1419	c.388C>G	c.(388-390)CGA>GGA	p.R130G		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).	R->M: Does not affect the ability to inhibit AKT/PKB activation.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130G(65)|p.R130*(61)|p.R130Q(43)|p.R130fs*4(12)|p.R130L(7)|p.R130P(4)|p.R55fs*1(4)|p.K128_R130del(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.K128fs*47(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.R130R(1)|p.F56fs*2(1)|p.G129fs*50(1)|p.G129fs*51(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGGAAAGGGACGAACTGGTGT	0.403	R130G(OV56_OVARY)|R130G(KMBC2_URINARY_TRACT)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			G	89692904	G	G	89692904	3	3	56	1	0	0	0	0	1	0	0	0	12738	528	19	5	406	5	PTEN	10	89692904	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	34110288	89692904	45841843	64	3605											
HTR7	3363	broad.mit.edu	37	chr10	92509172	92509172	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccactgcggtagagtaaatcGtatagccaaagtcctggctg	11	10	0	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr10:92509172G>A	uc001kha.2	-	2	962	c.719C>T	c.(718-720)ACG>ATG	p.T240M	HTR7_uc001kgz.2_Missense_Mutation_p.T240M|HTR7_uc001khb.2_Missense_Mutation_p.T240M	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	240	Helical; Name=5; (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	AGAGTAAATCGTATAGCCAAA	0.473													A	92509172	A	A	92509172	3	1	56	1	0	0	0	0	1	0	0	0	7452	1145	40	1	736	1	HTR7	10	92509172	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	2816268	92509172	43025575	65	3606											
AFAP1L2	84632	broad.mit.edu	37	chr10	116060363	116060363	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gggccatgcagaaaggacttGacaggtgtgaggtccaggta	16	7	0	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr10:116060363G>A	uc001lbn.2	-	14	1930	c.1629C>T	c.(1627-1629)GTC>GTT	p.V543V	AFAP1L2_uc001lbo.2_Silent_p.V543V|AFAP1L2_uc010qse.1_Silent_p.V596V|AFAP1L2_uc001lbp.2_Silent_p.V571V|AFAP1L2_uc001lbr.1_Silent_p.V543V|AFAP1L2_uc001lbm.2_Intron|AFAP1L2_uc010qsd.1_Silent_p.V109V|AFAP1L2_uc001lbq.1_Silent_p.V65V	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	543					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GAAAGGACTTGACAGGTGTGA	0.602													A	116060363	A	A	116060363	2	1	56	1	0	0	0	0	0	0	0	1	355	1277	45	3		3	AFAP1L2	10	116060363	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	23551191	116060363	19474384	66	3607											
ATRNL1	26033	broad.mit.edu	37	chr10	117607492	117607492	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcatcaggtgcccctcccccTgggcagtcaggtatgataaa	10	13	3	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr10:117607492T>G	uc001lcg.2	+	28	4394	c.4008T>G	c.(4006-4008)CCT>CCG	p.P1336P	ATRNL1_uc010qsm.1_Silent_p.P465P|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1336	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CCCCTCCCCCTGGGCAGTCAG	0.468													G	117607492	G	G	117607492	2	3	56	1	0	0	0	0	0	0	0	1	1207	1567	55	5		5	ATRNL1	10	117607492	Silent	SNP	T	TCGA-06-0649-01B-01W-0348-08	1547129	117607492	17927255	67	3608											
MKI67	4288	broad.mit.edu	37	chr10	129913850	129913850	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgtaaaccatcagcactttcTttctctgttgcgtaatcagt	6	10	4	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr10:129913850T>A	uc001lke.2	-	7	1017	c.822A>T	c.(820-822)AAA>AAT	p.K274N	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	274					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CAGCACTTTCTTTCTCTGTTG	0.443													A	129913850	A	A	129913850	3	1	56	1	0	0	0	0	1	0	0	0	9598	1606	56	5	8984	5	MKI67	10	129913850	Missense_Mutation	SNP	T	TCGA-06-0649-01B-01W-0348-08	12306358	129913850	5620897	68	3609											
CHRNA10	57053	broad.mit.edu	37	chr11	3687530	3687530	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttcctggcggcacagacatCgtggctcgtggcaagggccc	14	14	0	1	rs148252978		TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr11:3687530C>T	uc001lyf.2	-	5	1232	c.1160G>A	c.(1159-1161)CGA>CAA	p.R387Q	CHRNA10_uc010qxt.1_Missense_Mutation_p.R181Q|CHRNA10_uc010qxu.1_Missense_Mutation_p.R181Q	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	387	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	GCACAGACATCGTGGCTCGTG	0.667													T	3687530	T	T	3687530	3	4	56	1	0	0	0	0	1	0	0	0	3382	884	31	2	196	2	CHRNA10	11	3687530	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08		3687530	131318986	69	3610											
OR5I1	10798	broad.mit.edu	37	chr11	55703265	55703265	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgatttccactgagctgccGtatgtggagaggagccactc	12	10	0	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr11:55703265G>A	uc010ris.1	-	1	612	c.612C>T	c.(610-612)TAC>TAT	p.Y204Y		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGAGCTGCCGTATGTGGAGA	0.403													A	55703265	A	A	55703265	2	1	56	1	0	0	0	0	0	0	0	1	11164	1140	40	1		1	OR5I1	11	55703265	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	52015735	55703265	79303251	70	3611											
TCN1	6947	broad.mit.edu	37	chr11	59630104	59630104	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttttctagcttgtcgatcagGtggtaatcatatattaagtt	8	5	3	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr11:59630104G>T	uc001noj.2	-	3	449	c.351C>A	c.(349-351)CAC>CAA	p.H117Q		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	117					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGTCGATCAGGTGGTAATCAT	0.383													T	59630104	T	T	59630104	3	4	56	1	0	0	0	0	1	0	0	0	15703	1252	44	5	978	5	TCN1	11	59630104	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	3926839	59630104	75376412	71	3612											
FAT3	120114	broad.mit.edu	37	chr11	92624150	92624150	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tccagaggcacctcatcctcGgatgtgtctgccaactgcgg	11	14	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr11:92624150G>C	uc001pdj.3	+	25	13562	c.13545G>C	c.(13543-13545)TCG>TCC	p.S4515S	FAT3_uc001pdi.3_Silent_p.S987S	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4547	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCTCATCCTCGGATGTGTCTG	0.557										TCGA Ovarian(4;0.039)			C	92624150	C	C	92624150	2	2	56	1	0	0	0	0	0	0	0	1	5691	1103	39	5		5	FAT3	11	92624150	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	32994046	92624150	42382366	72	3613											
MMP20	9313	broad.mit.edu	37	chr11	102477401	102477401	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttccccaggaatactttcCgaggtcctaggattcaaaat	8	11	1	0	rs141875245	byFrequency	TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr11:102477401C>T	uc001phc.2	-	6	831	c.818G>A	c.(817-819)CGG>CAG	p.R273Q		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	273					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GAATACTTTCCGAGGTCCTAG	0.522													T	102477401	T	T	102477401	3	4	56	1	0	0	0	0	1	0	0	0	9659	652	23	2	653	2	MMP20	11	102477401	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	9853251	102477401	32529115	73	3614											
ARHGAP32	9743	broad.mit.edu	37	chr11	128994764	128994764	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taagagtaagatctccaggaAtctctggaacatctgcgcct	9	10	3	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr11:128994764A>G	uc009zcp.2	-	3	251	c.251T>C	c.(250-252)ATT>ACT	p.I84T	ARHGAP32_uc009zcq.1_Missense_Mutation_p.I44T	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	84					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						ATCTCCAGGAATCTCTGGAAC	0.328													G	128994764	G	G	128994764	3	3	56	1	0	0	0	0	1	0	0	0	881	101	4	4	6092	4	ARHGAP32	11	128994764	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	26517363	128994764	6011752	74	3615											
CACNA1C	775	broad.mit.edu	37	chr12	2786282	2786282	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatgaggtcaccgttggcaaGttctacgccacgttcctgat	11	11	2	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr12:2786282G>T	uc009zdu.1	+	42	5308	c.4995G>T	c.(4993-4995)AAG>AAT	p.K1665N	CACNA1C_uc009zdv.1_Missense_Mutation_p.K1614N|CACNA1C_uc001qkb.2_Missense_Mutation_p.K1617N|CACNA1C_uc001qkc.2_Missense_Mutation_p.K1636N|CACNA1C_uc001qke.2_Missense_Mutation_p.K1606N|CACNA1C_uc001qkf.2_Missense_Mutation_p.K1625N|CACNA1C_uc001qjz.2_Missense_Mutation_p.K1617N|CACNA1C_uc001qkd.2_Missense_Mutation_p.K1636N|CACNA1C_uc001qkg.2_Missense_Mutation_p.K1623N|CACNA1C_uc009zdw.1_Missense_Mutation_p.K1658N|CACNA1C_uc001qkh.2_Missense_Mutation_p.K1625N|CACNA1C_uc001qkl.2_Missense_Mutation_p.K1665N|CACNA1C_uc001qkn.2_Missense_Mutation_p.K1617N|CACNA1C_uc001qko.2_Missense_Mutation_p.K1637N|CACNA1C_uc001qkp.2_Missense_Mutation_p.K1617N|CACNA1C_uc001qkr.2_Missense_Mutation_p.K1634N|CACNA1C_uc001qku.2_Missense_Mutation_p.K1617N|CACNA1C_uc001qkq.2_Missense_Mutation_p.K1645N|CACNA1C_uc001qks.2_Missense_Mutation_p.K1617N|CACNA1C_uc001qkt.2_Missense_Mutation_p.K1636N|CACNA1C_uc001qki.1_Missense_Mutation_p.K1353N|CACNA1C_uc001qkj.1_Missense_Mutation_p.K1353N|CACNA1C_uc001qkk.1_Missense_Mutation_p.K1353N|CACNA1C_uc001qkm.1_Missense_Mutation_p.K1342N|CACNA1C_uc010sea.1_Missense_Mutation_p.K308N|uc001qkx.1_RNA|CACNA1C_uc001qky.1_5'Flank	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1665	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCGTTGGCAAGTTCTACGCCA	0.527													T	2786282	T	T	2786282	3	4	56	1	0	0	0	0	1	0	0	0	2540	1020	36	5	5392	5	CACNA1C	12	2786282	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08		2786282	131065613	75	3616											
KLRG1	10219	broad.mit.edu	37	chr12	9144889	9144889	+	Frame_Shift_Del	DEL	A	-	-													tctgagtgtgctgctataccAgtggatcctgtgccagggta							TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr12:9144889delA	uc001qvh.2	+	2	181	c.170delA	c.(169-171)CAGfs	p.Q57fs	KLRG1_uc001qvg.2_Frame_Shift_Del_p.Q57fs	NM_005810	NP_005801	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G,	57	Helical; Signal-anchor for type II membrane protein; (Potential).				cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			central_nervous_system(1)	1						CTGCTATACCAGTGGATCCTG	0.398													-	9144889	-	-	9144889	7	5	56	1	0	1	0	1	0	0	0	0	8421	188	7	0	176	0	KLRG1	12	9144889	Frame_Shift_Del	DEL	A	TCGA-06-0649-01B-01W-0348-08	6358607	9144889	124707006	76	3617											
PZP	5858	broad.mit.edu	37	chr12	9345129	9345129	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtaatggaaactgagctcCgataactctcccatggcctg	10	11	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr12:9345129C>T	uc001qvl.2	-	12	1490	c.1461G>A	c.(1459-1461)TCG>TCA	p.S487S	PZP_uc009zgl.2_Silent_p.S356S	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AACTGAGCTCCGATAACTCTC	0.483													T	9345129	T	T	9345129	2	4	56	1	0	0	0	0	0	0	0	1	12869	639	23	2		2	PZP	12	9345129	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	200240	9345129	124506766	77	3618											
GUCY2C	2984	broad.mit.edu	37	chr12	14827688	14827688	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ataggcaagagcaaagtctcGttttgtctaaataaaaaagg	9	5	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr12:14827688G>A	uc001rcd.2	-	8	1092	c.955C>T	c.(955-957)CGA>TGA	p.R319*	GUCY2C_uc009zhz.2_Nonsense_Mutation_p.R319*	NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	319	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						GCAAAGTCTCGTTTTGTCTAA	0.363													A	14827688	A	A	14827688	4	1	56	1	0	0	0	0	0	1	0	0	6896	1153	40	1	2346	1	GUCY2C	12	14827688	Nonsense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	5482559	14827688	119024207	78	3619											
ARHGAP9	64333	broad.mit.edu	37	chr12	57868660	57868660	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtctctgagaaaatgacctCttttatccacagcagcaatg	8	10	2	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr12:57868660C>T	uc001sod.2	-	16	2112	c.1919G>A	c.(1918-1920)AGA>AAA	p.R640K	ARHGAP9_uc001sny.2_RNA|ARHGAP9_uc001snz.2_Missense_Mutation_p.R366K|ARHGAP9_uc001soa.2_Missense_Mutation_p.R239K|ARHGAP9_uc001sob.2_Missense_Mutation_p.R550K|ARHGAP9_uc001soc.2_Missense_Mutation_p.R550K|ARHGAP9_uc001soe.1_Missense_Mutation_p.R629K	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	569	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			AAAATGACCTCTTTTATCCAC	0.527													T	57868660	T	T	57868660	3	4	56	1	0	0	0	0	1	0	0	0	889	913	32	3	570	3	ARHGAP9	12	57868660	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	43040972	57868660	75983235	79	3620											
EBPL	84650	broad.mit.edu	37	chr13	50243922	50243922	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taattacttacataaagaagCaatcaagccatcggaatttg	6	7	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr13:50243922C>A	uc001vdg.2	-	2	295	c.232G>T	c.(232-234)GCT>TCT	p.A78S	EBPL_uc001vdh.2_RNA|EBPL_uc001vdi.2_Missense_Mutation_p.A78S	NM_032565	NP_115954	Q9BY08	EBPL_HUMAN	emopamil binding related protein, delta8-delta7	78					sterol metabolic process	endoplasmic reticulum membrane|integral to membrane	cholestenol delta-isomerase activity				0		Lung NSC(96;0.000468)|Breast(56;0.0011)|Prostate(109;0.00243)|Hepatocellular(98;0.0556)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.06e-09)		CATAAAGAAGCAATCAAGCCA	0.358											OREG0022412	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	50243922	A	A	50243922	3	1	56	1	0	0	0	0	1	0	0	0	4887	710	25	5	400	5	EBPL	13	50243922	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08		50243922	64925956	80	3621											
TINF2	26277	broad.mit.edu	37	chr14	24709082	24709082	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaagggggtaggtattcaCagagagtgggtatcaaggtg	17	4	2	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr14:24709082C>T	uc001woa.3	-	9	1619	c.1277G>A	c.(1276-1278)TGT>TAT	p.C426Y	TINF2_uc010alm.2_3'UTR|TINF2_uc001wob.3_3'UTR|TINF2_uc010tof.1_Missense_Mutation_p.C391Y|TINF2_uc001woc.3_3'UTR	NM_001099274	NP_001092744	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	426					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|protein binding|telomeric DNA binding				0				GBM - Glioblastoma multiforme(265;0.0185)		TAGGTATTCACAGAGAGTGGG	0.463									Ataxia_Pancytopenia_syndrome|Congenital_Dyskeratosis				T	24709082	T	T	24709082	3	4	56	1	0	0	0	0	1	0	0	0	15920	478	17	3	82	3	TINF2	14	24709082	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08		24709082	82640458	81	3622											
ZBTB25	7597	broad.mit.edu	37	chr14	64953897	64953897	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttatgaccacagatggtaCagctcatttttcttttcctt	5	9	2	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr14:64953897C>T	uc001xhf.2	-	3	1235	c.1052G>A	c.(1051-1053)TGT>TAT	p.C351Y	ZBTB25_uc001xhc.2_Intron|ZBTB25_uc001xhg.2_Missense_Mutation_p.C351Y	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	351	C2H2-type 2.					cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		ACAGATGGTACAGCTCATTTT	0.368													T	64953897	T	T	64953897	3	4	56	1	0	0	0	0	1	0	0	0	17529	478	17	3	259	3	ZBTB25	14	64953897	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	40244815	64953897	42395643	82	3623											
LTBP2	4053	broad.mit.edu	37	chr14	75017917	75017917	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggctggcaggcagccagggCgggggtctggtctccacgct	19	12	2	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr14:75017917C>T	uc001xqa.2	-	7	1923	c.1536G>A	c.(1534-1536)CCG>CCA	p.P512P		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	512					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GCAGCCAGGGCGGGGGTCTGG	0.701													T	75017917	T	T	75017917	2	4	56	1	0	0	0	0	0	0	0	1	9074	755	27	1		1	LTBP2	14	75017917	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	10064020	75017917	32331623	83	3624											
SERPINA3	12	broad.mit.edu	37	chr14	95085658	95085658	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tataccttacttccgggacgAggagctgtcctgcaccgtgg	12	12	0	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr14:95085658A>T	uc001ydp.2	+	3	849	c.770A>T	c.(769-771)GAG>GTG	p.E257V	SERPINA3_uc001ydo.3_Missense_Mutation_p.E282V|SERPINA3_uc001ydr.2_Intron|SERPINA3_uc001ydq.2_Missense_Mutation_p.E257V|SERPINA3_uc001yds.2_Missense_Mutation_p.E257V|SERPINA3_uc010avg.2_Missense_Mutation_p.E257V	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	257					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TTCCGGGACGAGGAGCTGTCC	0.502													T	95085658	T	T	95085658	3	4	56	1	0	0	0	0	1	0	0	0	14090	304	11	5	776	5	SERPINA3	14	95085658	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	20067741	95085658	12263882	84	3625											
AHNAK2	113146	broad.mit.edu	37	chr14	105420083	105420083	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtcttccctgcccttgtcctGttcctcagtgatccttgtcc	7	16	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr14:105420083G>C	uc010axc.1	-	7	1825	c.1705C>G	c.(1705-1707)CAG>GAG	p.Q569E	AHNAK2_uc001ypx.2_Missense_Mutation_p.Q469E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	569						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCTTGTCCTGTTCCTCAGTG	0.542													C	105420083	C	C	105420083	3	2	56	1	0	0	0	0	1	0	0	0	415	1386	48	5	15686	5	AHNAK2	14	105420083	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	10334425	105420083	1929457	85	3626											
ATP8B4	79895	broad.mit.edu	37	chr15	50226374	50226374	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actgagaaatccacaggctcTttttcctgtaggagaacaac	8	10	1	2	rs114705901	by1000genomes	TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr15:50226374T>G	uc001zxu.2	-	15	1435	c.1293A>C	c.(1291-1293)AAA>AAC	p.K431N	ATP8B4_uc010ber.2_Missense_Mutation_p.K304N|ATP8B4_uc010ufd.1_Missense_Mutation_p.K304N|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	431	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CCACAGGCTCTTTTTCCTGTA	0.348													G	50226374	G	G	50226374	3	3	56	1	0	0	0	0	1	0	0	0	1197	1606	56	5	2341	5	ATP8B4	15	50226374	Missense_Mutation	SNP	T	TCGA-06-0649-01B-01W-0348-08		50226374	52305018	86	3627											
OR4F6	390648	broad.mit.edu	37	chr15	102346502	102346502	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggcttgcatagagacctacAcattgggattcatggttact	10	8	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr15:102346502A>G	uc010utr.1	+	1	580	c.580A>G	c.(580-582)ACA>GCA	p.T194A		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			AGAGACCTACACATTGGGATT	0.368													G	102346502	G	G	102346502	3	3	56	1	0	0	0	0	1	0	0	0	11066	159	6	4	582	4	OR4F6	15	102346502	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	52120128	102346502	184890	87	3628											
CYLD	1540	broad.mit.edu	37	chr16	50783900	50783900	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagataaatgaaaagttcacAgagttacttttggcaattac	8	5	1	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr16:50783900A>G	uc002egp.1	+	4	706	c.291A>G	c.(289-291)ACA>ACG	p.T97T	CYLD_uc002egn.1_Silent_p.T97T|CYLD_uc002ego.2_Silent_p.T97T|CYLD_uc010cbs.1_Silent_p.T97T|CYLD_uc002egq.1_Silent_p.T97T|CYLD_uc002egr.1_Silent_p.T97T|CYLD_uc002egs.1_Silent_p.T97T	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	97					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				AAAAGTTCACAGAGTTACTTT	0.378			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				G	50783900	G	G	50783900	2	3	56	1	0	0	0	0	0	0	0	1	4143	175	7	4		4	CYLD	16	50783900	Silent	SNP	A	TCGA-06-0649-01B-01W-0348-08		50783900	39570853	88	3629											
ACCN1	40	broad.mit.edu	37	chr17	32483431	32483431	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactgcccacagcacacgccGgatggtcagcggcccataca	10	17	1	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr17:32483431G>A	uc002hhu.2	-	1	395	c.121C>T	c.(121-123)CGG>TGG	p.R41W		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	41	Helical; (Potential).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	AGCACACGCCGGATGGTCAGC	0.602													A	32483431	A	A	32483431	3	1	56	1	0	0	0	0	1	0	0	0	128	1115	39	2	2169	2	ACCN1	17	32483431	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08		32483431	48711779	89	3630											
CDK12	51755	broad.mit.edu	37	chr17	37687203	37687203	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagaatccttggtccagacCctggtgaagaacaggacctt	10	11	0	4			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr17:37687203C>T	uc010cvv.2	+	14	4693	c.4107C>T	c.(4105-4107)ACC>ACT	p.T1369T	CDK12_uc002hrw.3_Silent_p.T1360T	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	1369					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						TGGTCCAGACCCTGGTGAAGA	0.552										TCGA Ovarian(9;0.13)			T	37687203	T	T	37687203	2	4	56	1	0	0	0	0	0	0	0	1	3128	610	22	3		3	CDK12	17	37687203	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	5203772	37687203	43508007	90	3631											
KRT222	125113	broad.mit.edu	37	chr17	38812778	38812778	+	Nonsense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acccttcatcagtggctgctAaatgaagatcaaatcgaaga	8	9	3	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr17:38812778A>C	uc002hvc.2	-	6	829	c.764T>G	c.(763-765)TTA>TGA	p.L255*	KRT222_uc010wfk.1_RNA|KRT222_uc002hvb.2_Nonsense_Mutation_p.L215*	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	truncated type I keratin KA21	255						intermediate filament	structural molecule activity			central_nervous_system(1)|skin(1)	2						AGTGGCTGCTAAATGAAGATC	0.378													C	38812778	C	C	38812778	4	2	56	1	0	0	0	0	0	1	0	0	8459	372	13	5	127	5	KRT222	17	38812778	Nonsense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	1125575	38812778	42382432	91	3632											
BRCA1	672	broad.mit.edu	37	chr17	41244603	41244603	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgacttgatgggaaaaagtGgtggtatacgatatgggttt	14	2	0	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr17:41244603G>A	uc002icq.2	-	10	3177	c.2945C>T	c.(2944-2946)CCA>CTA	p.P982L	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.P911L|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.P935L|BRCA1_uc002ict.2_Missense_Mutation_p.P982L|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.P982L|BRCA1_uc002ide.1_Missense_Mutation_p.P813L|BRCA1_uc010cyy.1_Missense_Mutation_p.P982L|BRCA1_uc010whs.1_Missense_Mutation_p.P982L|BRCA1_uc010cyz.2_Missense_Mutation_p.P935L|BRCA1_uc010cza.2_Missense_Mutation_p.P956L|BRCA1_uc010wht.1_Missense_Mutation_p.P686L	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	982					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGGAAAAAGTGGTGGTATACG	0.368			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			A	41244603	A	A	41244603	3	1	56	1	0	0	0	0	1	0	0	0	1498	1348	47	3	2772	3	BRCA1	17	41244603	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	2431825	41244603	39950607	92	3633											
DCAF7	10238	broad.mit.edu	37	chr17	61657190	61657190	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cactggttgtttgcaggtacCtcaagcattgatacgacatg	10	9	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr17:61657190C>A	uc002jbc.2	+	4	631	c.414C>A	c.(412-414)ACC>ACA	p.T138T	DCAF7_uc002jbb.2_RNA|DCAF7_uc010wpn.1_Intron	NM_005828	NP_005819	P61962	DCAF7_HUMAN	WD-repeat protein	138	WD 2.				multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			ovary(1)	1						TTGCAGGTACCTCAAGCATTG	0.562													A	61657190	A	A	61657190	2	1	56	1	0	0	0	0	0	0	0	1	4275	668	24	5		5	DCAF7	17	61657190	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	20412587	61657190	19538020	93	3634											
KPNA2	3838	broad.mit.edu	37	chr17	66033587	66033587	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgatgatgctacttctccGctgcaggaaaaccgcaacaa	8	13	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr17:66033587G>A	uc002jgk.2	+	3	321	c.189G>A	c.(187-189)CCG>CCA	p.P63P	KPNA2_uc002jgl.2_Silent_p.P63P	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	63					DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CTACTTCTCCGCTGCAGGAAA	0.398													A	66033587	A	A	66033587	2	1	56	1	0	0	0	0	0	0	0	1	8430	1074	38	1		1	KPNA2	17	66033587	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	4376397	66033587	15161623	94	3635											
MGAT5B	146664	broad.mit.edu	37	chr17	74900424	74900424	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcatctacctcagtgagGtcgagtggttctgccccccg	10	15	4	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr17:74900424G>A	uc002jti.2	+	5	746	c.643G>A	c.(643-645)GTC>ATC	p.V215I	MGAT5B_uc002jth.2_Missense_Mutation_p.V204I	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	204	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						CCTCAGTGAGGTCGAGTGGTT	0.662													A	74900424	A	A	74900424	3	1	56	1	0	0	0	0	1	0	0	0	9549	1261	44	3	733	3	MGAT5B	17	74900424	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	8866837	74900424	6294786	95	3636											
ENGASE	64772	broad.mit.edu	37	chr17	77081816	77081816	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcggcttggagagatccaGgtgatgcttcccagaggggc	16	9	0	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr17:77081816G>A	uc002jwv.2	+	13	1823	c.1815G>A	c.(1813-1815)CAG>CAA	p.Q605Q	ENGASE_uc002jww.2_Silent_p.Q310Q	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	605						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						GAGAGATCCAGGTGATGCTTC	0.677													A	77081816	A	A	77081816	2	1	56	1	0	0	0	0	0	0	0	1	5118	1014	35	3		3	ENGASE	17	77081816	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	2181392	77081816	4113394	96	3637											
SMCHD1	23347	broad.mit.edu	37	chr18	2705783	2705783	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tggagaagtatatgctacagGaggagaggttcaaattgcaa	13	4	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr18:2705783G>T	uc002klm.3	+	14	2123	c.1934G>T	c.(1933-1935)GGA>GTA	p.G645V	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_5'Flank	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	645					chromosome organization		ATP binding				0						TATGCTACAGGAGGAGAGGTT	0.333													T	2705783	T	T	2705783	3	4	56	1	0	0	0	0	1	0	0	0	14788	1174	41	5	1988	5	SMCHD1	18	2705783	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08		2705783	75371465	97	3638											
DSC1	1823	broad.mit.edu	37	chr18	28710546	28710546	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatctagaaactccagtccCtcttcttcctgccgatcgct	6	15	3	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr18:28710546C>T	uc002kwn.2	-	16	2878	c.2616G>A	c.(2614-2616)GAG>GAA	p.E872E	DSC1_uc002kwm.2_3'UTR|uc002kwo.1_5'Flank	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	872	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ACTCCAGTCCCTCTTCTTCCT	0.423													T	28710546	T	T	28710546	2	4	56	1	0	0	0	0	0	0	0	1	4765	680	24	3		3	DSC1	18	28710546	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	26004763	28710546	49366702	98	3639											
KIAA1012	22878	broad.mit.edu	37	chr18	29437807	29437807	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttagaacagcagtattacCaccgaaagtaaagaactctg	8	8	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr18:29437807C>T	uc002kxc.3	-	20	3248	c.2884G>A	c.(2884-2886)GGT>AGT	p.G962S	KIAA1012_uc002kxb.3_Missense_Mutation_p.G908S|KIAA1012_uc002kxd.3_Intron	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	962					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						GCAGTATTACCACCGAAAGTA	0.408													T	29437807	T	T	29437807	3	4	56	1	0	0	0	0	1	0	0	0	8204	594	21	3	1463	3	KIAA1012	18	29437807	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	727261	29437807	48639441	99	3640											
DOK6	220164	broad.mit.edu	37	chr18	67345078	67345078	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctggccgcaggagtgcagcGggaacagaatggtaggtgtg	18	7	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr18:67345078G>A	uc002lkl.2	+	4	588	c.398G>A	c.(397-399)CGG>CAG	p.R133Q		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	133	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GGAGTGCAGCGGGAACAGAAT	0.438													A	67345078	A	A	67345078	3	1	56	1	0	0	0	0	1	0	0	0	4701	1116	39	2	412	2	DOK6	18	67345078	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	37907271	67345078	10732170	100	3641											
C3	718	broad.mit.edu	37	chr19	6677935	6677935	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accatgctctcggtgaaggcGccgaggtcctggcattgttt	13	11	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:6677935G>A	uc002mfm.2	-	41	5012	c.4950C>T	c.(4948-4950)GGC>GGT	p.G1650G	C3_uc002mfl.2_Silent_p.G386G	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1650	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CGGTGAAGGCGCCGAGGTCCT	0.562													A	6677935	A	A	6677935	2	1	56	1	0	0	0	0	0	0	0	1	2204	1074	38	1		1	C3	19	6677935	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08		6677935	52451048	101	3642											
ZNF358	140467	broad.mit.edu	37	chr19	7584719	7584719	+	Frame_Shift_Del	DEL	C	-	-													ggtgccaccctggctcagcaCcgtggcatccacactggggc							TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:7584719delC	uc002mgn.2	+	2	761	c.591delC	c.(589-591)CACfs	p.H197fs	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	197	C2H2-type 2.				embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						TGGCTCAGCACCGTGGCATCC	0.711													-	7584719	-	-	7584719	7	5	56	1	0	1	0	1	0	0	0	0	17864	506	18	0	593	0	ZNF358	19	7584719	Frame_Shift_Del	DEL	C	TCGA-06-0649-01B-01W-0348-08	906784	7584719	51544264	102	3643											
MRI1	84245	broad.mit.edu	37	chr19	13876915	13876915	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cactgtaacactggtgctctGgccaccgctggctatggtac	11	13	1	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:13876915G>C	uc002mxe.2	+	3	585	c.519G>C	c.(517-519)CTG>CTC	p.L173L	MRI1_uc002mxf.2_Intron	NM_001031727	NP_001026897	Q9BV20	MTNA_HUMAN	translation initiation factor eIF-2B subunit	173					L-methionine salvage from methylthioadenosine	cell projection|cytoplasm|nucleus	identical protein binding|S-methyl-5-thioribose-1-phosphate isomerase activity			ovary(1)	1						CTGGTGCTCTGGCCACCGCTG	0.552													C	13876915	C	C	13876915	2	2	56	1	0	0	0	0	0	0	0	1	9770	1335	47	5		5	MRI1	19	13876915	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	6292196	13876915	45252068	103	3644											
ZNF461	92283	broad.mit.edu	37	chr19	37129609	37129609	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaacctgactggcttctcGccagtatgaagagtctgatg	12	9	2	4			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:37129609G>A	uc002oem.2	-	6	1866	c.1638C>T	c.(1636-1638)GGC>GGT	p.G546G	ZNF461_uc002oen.2_Silent_p.G515G|ZNF461_uc010xtj.1_Silent_p.G523G	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	546					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CTGGCTTCTCGCCAGTATGAA	0.388													A	37129609	A	A	37129609	2	1	56	1	0	0	0	0	0	0	0	1	17922	1074	38	1		1	ZNF461	19	37129609	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	23252694	37129609	21999374	104	3645											
CATSPERG	57828	broad.mit.edu	37	chr19	38861189	38861189	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagctagcgtgtttgtgggCctggtgatcttctacatcgc	12	10	3	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:38861189C>T	uc002oih.3	+	29	3324	c.3237C>T	c.(3235-3237)GGC>GGT	p.G1079G	CATSPERG_uc002oig.3_Silent_p.G1039G|CATSPERG_uc002oif.3_Silent_p.G719G|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	1079	Helical; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						TGTTTGTGGGCCTGGTGATCT	0.522													T	38861189	T	T	38861189	2	4	56	1	0	0	0	0	0	0	0	1	2692	726	26	3		3	CATSPERG	19	38861189	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	1731580	38861189	20267794	105	3646											
ZNF28	7576	broad.mit.edu	37	chr19	53303202	53303202	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tcattacacttgtaaggtttCtctccagtatgaagcctacg	7	10	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:53303202C>G	uc002qad.2	-	4	2016	c.1896G>C	c.(1894-1896)GAG>GAC	p.E632D	ZNF28_uc002qac.2_Missense_Mutation_p.E579D|ZNF28_uc010eqe.2_Missense_Mutation_p.E578D	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TGTAAGGTTTCTCTCCAGTAT	0.433													G	53303202	G	G	53303202	3	3	56	1	0	0	0	0	1	0	0	0	17810	912	32	5	264	5	ZNF28	19	53303202	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	14442013	53303202	5825781	106	3647			1	10		3	3	1098	C		9.77273e-06
ZNF28	7576	broad.mit.edu	37	chr19	53304215	53304215	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acattcataaggtttgtctgCagtatgaagcgccttgtgaa	10	7	2	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:53304215C>T	uc002qad.2	-	4	1003	c.883G>A	c.(883-885)GCA>ACA	p.A295T	ZNF28_uc002qac.2_Missense_Mutation_p.A242T|ZNF28_uc010eqe.2_Missense_Mutation_p.A241T	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		GGTTTGTCTGCAGTATGAAGC	0.388													T	53304215	T	T	53304215	3	4	56	1	0	0	0	0	1	0	0	0	17810	710	25	3	1277	3	ZNF28	19	53304215	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	1013	53304215	5824768	107	3648			1	10		3	3	1098	C		9.77273e-06
ZNF28	7576	broad.mit.edu	37	chr19	53304299	53304299	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	acacttgtaaggtttctcatCaatgtgagatctacgatggc	9	8	3	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:53304299C>G	uc002qad.2	-	4	919	c.799G>C	c.(799-801)GAT>CAT	p.D267H	ZNF28_uc002qac.2_Missense_Mutation_p.D214H|ZNF28_uc010eqe.2_Missense_Mutation_p.D213H	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		GGTTTCTCATCAATGTGAGAT	0.398													G	53304299	G	G	53304299	3	3	56	1	0	0	0	0	1	0	0	0	17810	826	29	5	1361	5	ZNF28	19	53304299	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	84	53304299	5824684	108	3649			1	10		3	3	1098	C		9.77273e-06
LILRB3	11025	broad.mit.edu	37	chr19	54746595	54746595	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcagggctgtgagggcgggCgtcatggcgtctccttccgg	18	11	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:54746595C>T	uc010erh.1	-	1	130	c.6G>A	c.(4-6)ACG>ACA	p.T2T	LILRA6_uc002qew.1_Intron|LILRB3_uc002qeh.1_Silent_p.T2T|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Silent_p.T2T|LILRA6_uc002qek.1_Silent_p.T2T|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Silent_p.T2T|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.T2T|LILRB3_uc002qep.1_Silent_p.T2T|LILRB3_uc002qeq.1_Silent_p.T2T|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Silent_p.T2T|LILRA6_uc010yep.1_Silent_p.T2T|LILRA6_uc010yeq.1_Silent_p.T2T|LILRA6_uc002qet.3_RNA|LILRA6_uc002qeu.1_Silent_p.T2T|LILRA6_uc002qev.1_5'Flank	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	2					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGAGGGCGGGCGTCATGGCGT	0.647													T	54746595	T	T	54746595	2	4	56	1	0	0	0	0	0	0	0	1	8792	755	27	1		1	LILRB3	19	54746595	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	1442296	54746595	4382388	109	3650											
NLRP7	199713	broad.mit.edu	37	chr19	55449588	55449588	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agatcctgccgagcccagttCggaatggttaggtaagtgca	13	9	0	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:55449588C>T	uc002qih.3	-	5	2029	c.1953G>A	c.(1951-1953)CCG>CCA	p.P651P	NLRP7_uc002qig.3_Intron|NLRP7_uc002qii.3_Silent_p.P651P|NLRP7_uc010esk.2_Silent_p.P651P|NLRP7_uc010esl.2_Silent_p.P679P	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	651			P -> S (in HYDM).				ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GAGCCCAGTTCGGAATGGTTA	0.453													T	55449588	T	T	55449588	2	4	56	1	0	0	0	0	0	0	0	1	10482	871	31	2		2	NLRP7	19	55449588	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	702993	55449588	3679395	110	3651											
PEG3	5178	broad.mit.edu	37	chr19	57335864	57335864	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggcccaacaaattccacatAgattaggttccgaaacctct	6	12	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr19:57335864A>T	uc002qnu.2	-	1	511	c.160T>A	c.(160-162)TAT>AAT	p.Y54N	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.Y54N|PEG3_uc002qnv.2_Missense_Mutation_p.Y54N|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Missense_Mutation_p.Y54N	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	54	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AATTCCACATAGATTAGGTTC	0.498													T	57335864	T	T	57335864	3	4	56	1	0	0	0	0	1	0	0	0	11720	420	15	5		5	PEG3	19	57335864	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	1886276	57335864	1793119	111	3652											
UMODL1	89766	broad.mit.edu	37	chr21	43519135	43519135	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acagaaccacactttccatgTccgggtttaccggggtatgg	11	11	0	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr21:43519135T>G	uc002zaf.1	+	7	1031	c.1031T>G	c.(1030-1032)GTC>GGC	p.V344G	UMODL1_uc002zad.1_Missense_Mutation_p.V272G|UMODL1_uc002zae.1_Missense_Mutation_p.V272G|UMODL1_uc002zag.1_Missense_Mutation_p.V344G|UMODL1_uc010gow.1_Missense_Mutation_p.V136G|UMODL1_uc002zai.1_5'UTR|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_5'UTR|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.V89G	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	344	Extracellular (Potential).|Fibronectin type-III 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						ACTTTCCATGTCCGGGTTTAC	0.547													G	43519135	G	G	43519135	3	3	56	1	0	0	0	0	1	0	0	0	16977	1667	58	5	1057	5	UMODL1	21	43519135	Missense_Mutation	SNP	T	TCGA-06-0649-01B-01W-0348-08		43519135	4610760	112	3653											
DGCR2	9993	broad.mit.edu	37	chr22	19044577	19044577	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtcgtggtgccgcagggtggGgaaatggaagcactgaagct	18	7	0	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr22:19044577G>C	uc002zoq.1	-	6	972	c.724C>G	c.(724-726)CCC>GCC	p.P242A	DGCR2_uc002zor.1_Missense_Mutation_p.P18A|DGCR2_uc011agr.1_Missense_Mutation_p.P198A	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	242	Extracellular (Potential).				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					CGCAGGGTGGGGAAATGGAAG	0.572													C	19044577	C	C	19044577	3	2	56	1	0	0	0	0	1	0	0	0	4461	1232	43	5	948	5	DGCR2	22	19044577	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08		19044577	32259989	113	3654											
CACNA1I	8911	broad.mit.edu	37	chr22	39966921	39966921	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcccacacccagacctggCgcctattgccttcttctgcc	7	18	2	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chr22:39966921C>T	uc003ayc.2	+	1	164	c.164C>T	c.(163-165)GCG>GTG	p.A55V	CACNA1I_uc003ayd.2_Missense_Mutation_p.A55V	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	55	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CCAGACCTGGCGCCTATTGCC	0.657													T	39966921	T	T	39966921	3	4	56	1	0	0	0	0	1	0	0	0	2546	768	27	1	166	1	CACNA1I	22	39966921	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	20922344	39966921	11337645	114	3655											
DDX53	168400	broad.mit.edu	37	chrX	23019452	23019452	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tcttatttgaaagatcctatGattgtttatgttggtaatct	7	4	2	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:23019452G>T	uc004daj.2	+	1	1366	c.1278G>T	c.(1276-1278)ATG>ATT	p.M426I		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	426	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						AAGATCCTATGATTGTTTATG	0.373													T	23019452	T	T	23019452	3	4	56	1	0	0	0	0	1	0	0	0	4371	1290	45	5	1280	5	DDX53	23	23019452	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08		23019452	132251108	115	3656											
PIM2	11040	broad.mit.edu	37	chrX	48775821	48775821	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	catgacggatacctggagtcGatctgtgaggcggtgtcctg	15	9	1	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:48775821G>A	uc004dls.2	-	2	465	c.163C>T	c.(163-165)CGA>TGA	p.R55*		NM_006875	NP_006866	Q9P1W9	PIM2_HUMAN	serine/threonine protein kinase pim-2	55	Protein kinase.				anti-apoptosis|cell proliferation|male meiosis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|response to virus		ATP binding|protein serine/threonine kinase activity			lung(3)|stomach(1)	4						ACCTGGAGTCGATCTGTGAGG	0.652													A	48775821	A	A	48775821	4	1	56	1	0	0	0	0	0	1	0	0	11928	1066	37	2	792	2	PIM2	23	48775821	Nonsense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	25756369	48775821	106494739	116	3657											
CSTF2	1478	broad.mit.edu	37	chrX	100075410	100075410	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgactcaacagagctatggCgggtttgactgtgagagacc	13	10	1	4			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:100075410C>T	uc004egh.2	+	1	63	c.5C>T	c.(4-6)GCG>GTG	p.A2V	CSTF2_uc010nnd.2_Missense_Mutation_p.A2V|CSTF2_uc004egi.2_Missense_Mutation_p.A2V	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	2					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						AGAGCTATGGCGGGTTTGACT	0.597													T	100075410	T	T	100075410	3	4	56	1	0	0	0	0	1	0	0	0	3984	768	27	1	7	1	CSTF2	23	100075410	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	51299589	100075410	55195150	117	3658											
BCORL1	63035	broad.mit.edu	37	chrX	129155121	129155121	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaacgagccgacagccacgaGgaaggtaggccccgcggccc	14	15	0	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:129155121G>A	uc004evb.1	+	5	3717	c.3603G>A	c.(3601-3603)GAG>GAA	p.E1201E	BCORL1_uc010nrd.1_Silent_p.E1103E	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1201					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						ACAGCCACGAGGAAGGTAGGC	0.637													A	129155121	A	A	129155121	2	1	56	1	0	0	0	0	0	0	0	1	1387	991	35	3		3	BCORL1	23	129155121	Silent	SNP	G	TCGA-06-0649-01B-01W-0348-08	29079711	129155121	26115439	118	3659											
SLC25A14	9016	broad.mit.edu	37	chrX	129506901	129506901	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agttttttattacatacgagCagctaaagaggcttcaaatc	7	7	1	1			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:129506901C>A	uc004evn.1	+	11	1168	c.955C>A	c.(955-957)CAG>AAG	p.Q319K	SLC25A14_uc004evo.1_Missense_Mutation_p.Q140K|SLC25A14_uc004evp.1_Missense_Mutation_p.Q319K|SLC25A14_uc004evq.1_Missense_Mutation_p.Q316K|SLC25A14_uc004evr.1_Missense_Mutation_p.Q347K	NM_003951	NP_003942	O95258	UCP5_HUMAN	solute carrier family 25, member 14 isoform	319	Solcar 3.				aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			ovary(1)	1						TACATACGAGCAGCTAAAGAG	0.398													A	129506901	A	A	129506901	3	1	56	1	0	0	0	0	1	0	0	0	14476	711	25	5	993	5	SLC25A14	23	129506901	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	351780	129506901	25763659	119	3660											
FRMD7	90167	broad.mit.edu	37	chrX	131214270	131214270	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctcccttttctcccatattcCaaaagttgcctttgggttcg	6	13	1	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:131214270C>A	uc004ewn.2	-	10	1108	c.930G>T	c.(928-930)TTG>TTT	p.L310F	FRMD7_uc011muy.1_Missense_Mutation_p.L295F	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	310					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TCCCATATTCCAAAAGTTGCC	0.373													A	131214270	A	A	131214270	3	1	56	1	0	0	0	0	1	0	0	0	6055	593	21	5	1226	5	FRMD7	23	131214270	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	1707369	131214270	24056290	120	3661											
SPANXN3	139067	broad.mit.edu	37	chrX	142596854	142596854	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgatggagttctcttgggaCtgttcattctccagttgatt	10	7	3	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:142596854C>T	uc004fbw.2	-	2	304	c.216G>A	c.(214-216)CAG>CAA	p.Q72Q		NM_001009609	NP_001009609	Q5MJ09	SPXN3_HUMAN	SPANX-N3 protein	72										ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCTTGGGACTGTTCATTCT	0.388													T	142596854	T	T	142596854	2	4	56	1	0	0	0	0	0	0	0	1	14992	564	20	3		3	SPANXN3	23	142596854	Silent	SNP	C	TCGA-06-0649-01B-01W-0348-08	11382584	142596854	12673706	121	3662											
UBE2NL	389898	broad.mit.edu	37	chrX	142967366	142967366	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagggagggacttttaaacGtgaactattacttgcagaag	12	5	0	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:142967366G>A	uc004fca.2	+	1	194	c.164G>A	c.(163-165)CGT>CAT	p.R55H		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	55							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					ACTTTTAAACGTGAACTATTA	0.418													A	142967366	A	A	142967366	3	1	56	1	0	0	0	0	1	0	0	0	16864	1145	40	1	166	1	UBE2NL	23	142967366	Missense_Mutation	SNP	G	TCGA-06-0649-01B-01W-0348-08	370512	142967366	12303194	122	3663											
UBE2NL	389898	broad.mit.edu	37	chrX	142967428	142967428	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagtacgtttcatgaccaaaAtttatcatccaaatgtagac	5	8	2	2			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:142967428A>G	uc004fca.2	+	1	256	c.226A>G	c.(226-228)ATT>GTT	p.I76V		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	76							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					CATGACCAAAATTTATCATCC	0.408													G	142967428	G	G	142967428	3	3	56	1	0	0	0	0	1	0	0	0	16864	101	4	4	228	4	UBE2NL	23	142967428	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	62	142967428	12303132	123	3664											
IRAK1	3654	broad.mit.edu	37	chrX	153278845	153278845	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccgaatgcccgggcacccCcgccaccactgcctgcagct	9	21	0	0			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:153278845C>T	uc004fjs.1	-	12	1658	c.1579G>A	c.(1579-1581)GGG>AGG	p.G527R	IRAK1_uc004fjr.1_Intron|IRAK1_uc004fjt.1_Missense_Mutation_p.G448R|IRAK1_uc010nur.2_Intron	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	527					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGGGCACCCCCGCCACCACT	0.667													T	153278845	T	T	153278845	3	4	56	1	0	0	0	0	1	0	0	0	7821	623	22	3	571	3	IRAK1	23	153278845	Missense_Mutation	SNP	C	TCGA-06-0649-01B-01W-0348-08	10311417	153278845	1991715	124	3665											
F8	2157	broad.mit.edu	37	chrX	154225292	154225292	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caccaacagcatgaagactgAcaggatgggaagccatgttc	11	10	0	3			TCGA-06-0649-01B-01W-0348-08	TCGA-06-0649-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	27af6a5f-993d-41f0-a9af-65e5a8cc41d4	626b3d9d-1fa3-4117-a1f9-e4e7d7182617	g.chrX:154225292A>T	uc004fmt.2	-	3	515	c.344T>A	c.(343-345)GTC>GAC	p.V115D	F8_uc011mzx.1_Missense_Mutation_p.V80D	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	115	Plastocyanin-like 1.|F5/8 type A 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	ATGAAGACTGACAGGATGGGA	0.448													T	154225292	T	T	154225292	3	4	56	1	0	0	0	0	1	0	0	0	5350	275	10	5	6835	5	F8	23	154225292	Missense_Mutation	SNP	A	TCGA-06-0649-01B-01W-0348-08	946447	154225292	1045268	125	3666											
CPSF3L	54973	broad.mit.edu	37	chr1	1249704	1249704	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aaggtctccaggaggatgcaGagctcctgggcgcggcccag	16	12	1	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr1:1249704G>C	uc001aee.1	-	8	802	c.744C>G	c.(742-744)CTC>CTG	p.L248L	CPSF3L_uc009vjy.1_RNA|CPSF3L_uc001aef.1_Silent_p.L254L|CPSF3L_uc009vjz.1_Silent_p.L226L|CPSF3L_uc010nyj.1_Silent_p.L219L|CPSF3L_uc001aeg.1_Silent_p.L124L|CPSF3L_uc001aeh.1_Silent_p.L147L|CPSF3L_uc001aei.1_Silent_p.L150L|CPSF3L_uc001aej.1_Silent_p.L75L|CPSF3L_uc001aek.1_5'UTR	NM_017871	NP_060341	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor	248						Golgi apparatus|nucleus	hydrolase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		GGAGGATGCAGAGCTCCTGGG	0.667													C	1249704	C	C	1249704	2	2	57	1	0	0	0	0	0	0	0	1	3827	929	33	5		5	CPSF3L	1	1249704	Silent	SNP	G	TCGA-06-0650-01A-02D-1696-08		1249704	248000917	1	3667											
THEM5	284486	broad.mit.edu	37	chr1	151820732	151820732	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagttttagaaaaggtctcGtccatcatggctgccaggga	12	9	2	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr1:151820732G>A	uc009wnd.2	-	4	633	c.501C>T	c.(499-501)GAC>GAT	p.D167D		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	167							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AAAAGGTCTCGTCCATCATGG	0.587													A	151820732	A	A	151820732	2	1	57	1	0	0	0	0	0	0	0	1	15856	1136	40	1		1	THEM5	1	151820732	Silent	SNP	G	TCGA-06-0650-01A-02D-1696-08	150571028	151820732	97429889	2	3668											
HNRPLL	92906	broad.mit.edu	37	chr2	38812883	38812883	+	Frame_Shift_Del	DEL	C	-	-													ctggccgagtgatccttttgCttgtagaatagttgaaaaaa							TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr2:38812883delC	uc002rqw.2	-	3	859	c.449delG	c.(448-450)AGCfs	p.S150fs	HNRPLL_uc002rqx.2_Frame_Shift_Del_p.S145fs	NM_138394	NP_612403	Q8WVV9	HNRLL_HUMAN	heterogeneous nuclear ribonucleoprotein L-like	150	RRM 1.				mRNA processing|positive regulation of RNA splicing	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			skin(1)	1		all_hematologic(82;0.248)				GATCCTTTTGCTTGTAGAATA	0.408													-	38812883	-	-	38812883	7	5	57	1	0	1	0	1	0	0	0	0	7277	797	28	0	1223	0	HNRPLL	2	38812883	Frame_Shift_Del	DEL	C	TCGA-06-0650-01A-02D-1696-08		38812883	204386490	3	3669											
C2orf89	129293	broad.mit.edu	37	chr2	85051124	85051124	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgaattgccggagtcgcggCctccgctgtgaccgcctccg	13	16	0	2			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr2:85051124C>A	uc010ysl.1	-	6	1376	c.1287G>T	c.(1285-1287)AGG>AGT	p.R429S	C2orf89_uc002sou.3_Missense_Mutation_p.R380S	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	429	Extracellular (Potential).					integral to membrane				ovary(1)	1						GGAGTCGCGGCCTCCGCTGTG	0.652													A	85051124	A	A	85051124	3	1	57	1	0	0	0	0	1	0	0	0	2203	738	26	5	238	5	C2orf89	2	85051124	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	46238241	85051124	158148249	4	3670											
CASR	846	broad.mit.edu	37	chr3	121976021	121976021	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcttcccaacttgacgctGggatacaggatatttgacac	8	11	1	2			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr3:121976021G>A	uc003eev.3	+	3	651	c.279G>A	c.(277-279)CTG>CTA	p.L93L	CASR_uc003eew.3_Silent_p.L93L	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	93	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	ACTTGACGCTGGGATACAGGA	0.448													A	121976021	A	A	121976021	2	1	57	1	0	0	0	0	0	0	0	1	2682	1335	47	3		3	CASR	3	121976021	Silent	SNP	G	TCGA-06-0650-01A-02D-1696-08		121976021	76046409	5	3671											
RBM47	54502	broad.mit.edu	37	chr4	40440364	40440364	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcggccgcgctggcgtagaCgatcacgtccagcacgccct	13	16	1	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr4:40440364C>T	uc003gvc.2	-	4	1257	c.547G>A	c.(547-549)GTC>ATC	p.V183I	RBM47_uc003gvd.2_Missense_Mutation_p.V183I|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.V145I|RBM47_uc003gvg.1_Missense_Mutation_p.V183I	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	183	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						CTGGCGTAGACGATCACGTCC	0.637													T	40440364	T	T	40440364	3	4	57	1	0	0	0	0	1	0	0	0	13141	536	19	1	1250	1	RBM47	4	40440364	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08		40440364	150713912	6	3672											
CSN1S1	1446	broad.mit.edu	37	chr4	70810660	70810660	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttcctttcccaccgttttcCgacatctccaatcccactgc	4	18	1	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr4:70810660C>T	uc003hep.1	+	15	544	c.495C>T	c.(493-495)TCC>TCT	p.S165S	CSN1S1_uc003heq.1_Silent_p.S156S|CSN1S1_uc003her.1_Silent_p.S157S	NM_001890	NP_001881	P47710	CASA1_HUMAN	casein alpha s1 isoform 1	165						extracellular region	protein binding|transporter activity				0						CACCGTTTTCCGACATCTCCA	0.423													T	70810660	T	T	70810660	2	4	57	1	0	0	0	0	0	0	0	1	3947	639	23	2		2	CSN1S1	4	70810660	Silent	SNP	C	TCGA-06-0650-01A-02D-1696-08	30370296	70810660	120343616	7	3673											
FRAS1	80144	broad.mit.edu	37	chr4	79396642	79396642	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtgtcacggtgcagaggaCtgggaacctgaaccaatatg	13	9	1	2			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr4:79396642C>T	uc003hlb.2	+	54	8173	c.7733C>T	c.(7732-7734)ACT>ATT	p.T2578I		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2577	Calx-beta 1.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GTGCAGAGGACTGGGAACCTG	0.542													T	79396642	T	T	79396642	3	4	57	1	0	0	0	0	1	0	0	0	6042	565	20	3	8022	3	FRAS1	4	79396642	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	8585982	79396642	111757634	8	3674											
ABLIM3	22885	broad.mit.edu	37	chr5	148637907	148637907	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttggcatgaccatctctgaGtttgaccggctggccctctg	11	12	2	3			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr5:148637907G>C	uc003lpy.2	+	24	2243	c.1992G>C	c.(1990-1992)GAG>GAC	p.E664D	ABLIM3_uc003lpz.1_Missense_Mutation_p.E664D|ABLIM3_uc003lqa.1_Missense_Mutation_p.E561D|ABLIM3_uc003lqb.2_Intron|ABLIM3_uc003lqc.1_Missense_Mutation_p.E631D|ABLIM3_uc003lqd.1_Missense_Mutation_p.E569D|ABLIM3_uc003lqf.2_Intron|ABLIM3_uc003lqe.1_Missense_Mutation_p.E553D	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	664	HP.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATCTCTGAGTTTGACCGGC	0.517													C	148637907	C	C	148637907	3	2	57	1	0	0	0	0	1	0	0	0	96	1020	36	5	2082	5	ABLIM3	5	148637907	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08		148637907	32277353	9	3675											
LY6G6F	259215	broad.mit.edu	37	chr6	31675363	31675363	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagcaggctccttcaccaccCtggtagcccaagtccaagtg	9	16	1	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr6:31675363C>A	uc003nwa.1	+	2	181	c.181C>A	c.(181-183)CTG>ATG	p.L61M	BAT5_uc011dnz.1_Intron|LY6G6F_uc003nwb.1_Missense_Mutation_p.L61M	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	61	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						CTTCACCACCCTGGTAGCCCA	0.592													A	31675363	A	A	31675363	3	1	57	1	0	0	0	0	1	0	0	0	9096	680	24	5	187	5	LY6G6F	6	31675363	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08		31675363	139439704	10	3676											
TBX18	9096	broad.mit.edu	37	chr6	85446758	85446758	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggagctggggggacattcccGaaatctgcatggataagctg	15	8	1	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr6:85446758G>A	uc003pkl.1	-	8	1469	c.1469C>T	c.(1468-1470)TCG>TTG	p.S490L	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	490					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GGACATTCCCGAAATCTGCAT	0.527													A	85446758	A	A	85446758	3	1	57	1	0	0	0	0	1	0	0	0	15650	1059	37	2	358	2	TBX18	6	85446758	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08	53771395	85446758	85668309	11	3677											
ASCC3	10973	broad.mit.edu	37	chr6	101037629	101037629	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcggccataagttagaggttCaatgctgcgattatcctatt	9	8	1	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr6:101037629C>T	uc003pqk.2	-	36	5760	c.5431G>A	c.(5431-5433)GAA>AAA	p.E1811K		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1811					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GTTAGAGGTTCAATGCTGCGA	0.343													T	101037629	T	T	101037629	3	4	57	1	0	0	0	0	1	0	0	0	1033	835	29	3	1205	3	ASCC3	6	101037629	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	15590871	101037629	70077438	12	3678											
PNLDC1	154197	broad.mit.edu	37	chr6	160240368	160240368	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggaggcactccccaaacGtcaactgcctgctccagtaa	8	15	1	0	rs138386704		TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr6:160240368G>A	uc003qsx.1	+	18	1654	c.1483G>A	c.(1483-1485)GTC>ATC	p.V495I	PNLDC1_uc003qsy.1_Missense_Mutation_p.V506I	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	495	Helical; Anchor for type IV membrane protein; (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CTCCCCAAACGTCAACTGCCT	0.617													A	160240368	A	A	160240368	3	1	57	1	0	0	0	0	1	0	0	0	12148	1145	40	1	1549	1	PNLDC1	6	160240368	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08	59202739	160240368	10874699	13	3679											
QKI	9444	broad.mit.edu	37	chr6	163956153	163956153	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agtgaagaaattattggtacCtgcagtaagtaataatttcc	8	5	0	2			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr6:163956153C>G	uc003qui.2	+	4	1093	c.542C>G	c.(541-543)CCT>CGT	p.P181R	QKI_uc003que.2_Missense_Mutation_p.P181R|QKI_uc003quf.2_Missense_Mutation_p.P181R|QKI_uc003qug.2_Missense_Mutation_p.P181R|QKI_uc003quh.2_Missense_Mutation_p.P181R|QKI_uc003quj.2_Missense_Mutation_p.P181R	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	181					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		TTATTGGTACCTGCAGTAAGT	0.333													G	163956153	G	G	163956153	3	3	57	1	0	0	0	0	1	0	0	0	12873	681	24	5	556	5	QKI	6	163956153	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	3715785	163956153	7158914	14	3680											
EGFR	1956	broad.mit.edu	37	chr7	55223531	55223533	+	In_Frame_Del	DEL	GTG	-	-													tctcttccccaggtaattatGtggtgacagatcacggctcg							TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr7:55223531_55223533delGTG	uc003tqk.2	+	8	1144_1146	c.898_900delGTG	c.(898-900)GTGdel	p.V301del	EGFR_uc003tqh.2_In_Frame_Del_p.V301del|EGFR_uc003tqi.2_In_Frame_Del_p.V301del|EGFR_uc003tqj.2_In_Frame_Del_p.V301del|EGFR_uc010kzg.1_In_Frame_Del_p.V256del|EGFR_uc011kco.1_In_Frame_Del_p.V248del|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	301	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V301V(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGGTAATTATGTGGTGACAGATC	0.601		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			-	55223533	-	-	55223531	7	5	57	1	0	1	0	1	0	0	0	0	4967	1377	48	0	928	0	EGFR	7	55223531	In_Frame_Del	DEL	GTG	TCGA-06-0650-01A-02D-1696-08		55223531	103915132	15	3681											
EGFR	1956	broad.mit.edu	37	chr7	55241677	55241677	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctctcttgaggatcttgaagGaaactgaattcaaaaagatc	8	7	3	4			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr7:55241677G>A	uc003tqk.2	+	18	2371	c.2125G>A	c.(2125-2127)GAA>AAA	p.E709K	EGFR_uc010kzg.1_Missense_Mutation_p.E664K|EGFR_uc011kco.1_Missense_Mutation_p.E656K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	709	Cytoplasmic (Potential).		E -> K (found in a lung cancer sample).|E -> A (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E709K(17)|p.E709A(11)|p.E709G(7)|p.E709V(5)|p.E709_T710>D(5)|p.E709H(2)|p.E709_T710>G(1)|p.E709_T710>A(1)|p.E709fs*1(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATCTTGAAGGAAACTGAATT	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55241677	A	A	55241677	3	1	57	1	0	0	0	0	1	0	0	0	4967	1175	41	3	2459	3	EGFR	7	55241677	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08	18146	55241677	103896986	16	3682			1	11		2	2	32	G		4.305915e-05
EGFR	1956	broad.mit.edu	37	chr7	55241708	55241708	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaaagatcaaagtgctggGctccggtgcgttcggcacgg	14	10	1	1	rs121913428		TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr7:55241708G>A	uc003tqk.2	+	18	2402	c.2156G>A	c.(2155-2157)GGC>GAC	p.G719D	EGFR_uc010kzg.1_Missense_Mutation_p.G674D|EGFR_uc011kco.1_Missense_Mutation_p.G666D	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	719	Cytoplasmic (Potential).|Protein kinase.|ATP.		G -> A (found in a lung cancer sample).|G -> D (found in a lung cancer sample).|G -> S (found in a lung cancer sample; somatic mutation; strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G719S(61)|p.G719A(52)|p.G719C(31)|p.G719?(9)|p.G719D(6)|p.G719V(1)|p.G719fs*29(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAAGTGCTGGGCTCCGGTGCG	0.582		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55241708	A	A	55241708	3	1	57	1	0	0	0	0	1	0	0	0	4967	1203	42	3	2490	3	EGFR	7	55241708	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08	31	55241708	103896955	17	3683			1	11		2	2	32	G		4.305915e-05
MUC17	140453	broad.mit.edu	37	chr7	100678917	100678917	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatacctgtcagcaccacgcCggtagtcagttctgaggcta	10	12	3	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr7:100678917C>T	uc003uxp.1	+	3	4273	c.4220C>T	c.(4219-4221)CCG>CTG	p.P1407L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1407	Extracellular (Potential).|59 X approximate tandem repeats.|21.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCACCACGCCGGTAGTCAGT	0.512													T	100678917	T	T	100678917	3	4	57	1	0	0	0	0	1	0	0	0	9974	652	23	2	4230	2	MUC17	7	100678917	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	45437209	100678917	58459746	18	3684											
KCND2	3751	broad.mit.edu	37	chr7	120386073	120386073	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtggagagaacacctctGtctaacaggtacctgagatt	11	8	2	2			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr7:120386073G>T	uc003vjj.1	+	5	2672	c.1707G>T	c.(1705-1707)CTG>CTT	p.L569L		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	569	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GAACACCTCTGTCTAACAGGT	0.443													T	120386073	T	T	120386073	2	4	57	1	0	0	0	0	0	0	0	1	8019	1364	48	5		5	KCND2	7	120386073	Silent	SNP	G	TCGA-06-0650-01A-02D-1696-08	19707156	120386073	38752590	19	3685											
TSGA14	95681	broad.mit.edu	37	chr7	130038800	130038800	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgagtggctggcggggcCgccacctggcagattctgag	17	10	1	3			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr7:130038800C>T	uc003vpz.2	-	11	1101	c.1054G>A	c.(1054-1056)GGC>AGC	p.G352S	TSGA14_uc003vpy.2_Missense_Mutation_p.G114S|TSGA14_uc010lmf.2_Missense_Mutation_p.G149S|TSGA14_uc003vqa.2_Missense_Mutation_p.G280S|TSGA14_uc011kpg.1_Missense_Mutation_p.G264S	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	352					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					CTGGCGGGGCCGCCACCTGGC	0.562													T	130038800	T	T	130038800	3	4	57	1	0	0	0	0	1	0	0	0	16617	652	23	2	71	2	TSGA14	7	130038800	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	9652727	130038800	29099863	20	3686											
KCNB2	9312	broad.mit.edu	37	chr8	73848725	73848725	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttggtgggccaccatcaccAtgaccactgttggctatggt	11	11	1	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr8:73848725A>G	uc003xzb.2	+	3	1723	c.1135A>G	c.(1135-1137)ATG>GTG	p.M379V		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	379					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CACCATCACCATGACCACTGT	0.448													G	73848725	G	G	73848725	3	3	57	1	0	0	0	0	1	0	0	0	8013	217	8	4	1141	4	KCNB2	8	73848725	Missense_Mutation	SNP	A	TCGA-06-0650-01A-02D-1696-08		73848725	72515297	21	3687											
PTPRD	5789	broad.mit.edu	37	chr9	8485910	8485910	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagctggaacaataagctgCtccatcgggagaagggggat	14	8	1	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr9:8485910C>T	uc003zkk.2	-	27	3618	c.2907G>A	c.(2905-2907)GAG>GAA	p.E969E	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Silent_p.E960E|PTPRD_uc003zkm.2_Silent_p.E956E|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	969	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CAATAAGCTGCTCCATCGGGA	0.468										TSP Lung(15;0.13)			T	8485910	T	T	8485910	2	4	57	1	0	0	0	0	0	0	0	1	12799	796	28	3		3	PTPRD	9	8485910	Silent	SNP	C	TCGA-06-0650-01A-02D-1696-08		8485910	132727521	22	3688											
MUC2	4583	broad.mit.edu	37	chr11	1096432	1096432	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaggagatcagcccctccGtggacaacttcggagtttac	12	11	1	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr11:1096432G>A	uc001lsx.1	+	37	13570	c.13543G>A	c.(13543-13545)GTG>ATG	p.V4515M		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4515	VWFD 4.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CAGCCCCTCCGTGGACAACTT	0.607													A	1096432	A	A	1096432	3	1	57	1	0	0	0	0	1	0	0	0	9975	1145	40	1	6583	1	MUC2	11	1096432	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08		1096432	133910084	23	3689											
PTPRJ	5795	broad.mit.edu	37	chr11	48145364	48145364	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcaatacaacatcaacccGtatcttctacaatcaaataa	2	11	5	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr11:48145364G>A	uc001ngp.3	+	5	1171	c.816G>A	c.(814-816)CCG>CCA	p.P272P	PTPRJ_uc001ngo.3_Silent_p.P272P	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	272	Extracellular (Potential).|Fibronectin type-III 2.|Fibronectin type-III 3.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						ACATCAACCCGTATCTTCTAC	0.473													A	48145364	A	A	48145364	2	1	57	1	0	0	0	0	0	0	0	1	12804	1132	40	1		1	PTPRJ	11	48145364	Silent	SNP	G	TCGA-06-0650-01A-02D-1696-08	47048932	48145364	86861152	24	3690											
SPDYC	387778	broad.mit.edu	37	chr11	64939756	64939756	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggtctacttccagcgcgccCacctgaagctcagcgagtat	10	14	2	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr11:64939756C>A	uc010rnz.1	+	4	298	c.298C>A	c.(298-300)CAC>AAC	p.H100N		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C	100	Speedy/Ringo box; Required for CDK- binding (By similarity).				cell cycle	nucleus	protein kinase binding				0						CCAGCGCGCCCACCTGAAGCT	0.597													A	64939756	A	A	64939756	3	1	57	1	0	0	0	0	1	0	0	0	15027	594	21	5	312	5	SPDYC	11	64939756	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	16794392	64939756	70066760	25	3691											
INTS4	92105	broad.mit.edu	37	chr11	77632412	77632412	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ggcaggaacaagatgagaaaGactgtctcggaggtaggcat	15	6	1	3			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr11:77632412G>C	uc001oys.2	-	14	1766	c.1738C>G	c.(1738-1740)CTT>GTT	p.L580V	INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	580					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			AGATGAGAAAGACTGTCTCGG	0.393													C	77632412	C	C	77632412	3	2	57	1	0	0	0	0	1	0	0	0	7780	942	33	5	1193	5	INTS4	11	77632412	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08	12692656	77632412	57374104	26	3692											
PARP4	143	broad.mit.edu	37	chr13	25009059	25009059	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggagcagactgtgcagagCttaatgagctccctgaaaaa	12	8	0	4			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr13:25009059C>T	uc001upl.2	-	31	4326	c.4220G>A	c.(4219-4221)AGC>AAC	p.S1407N		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1407					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		CTGTGCAGAGCTTAATGAGCT	0.542													T	25009059	T	T	25009059	3	4	57	1	0	0	0	0	1	0	0	0	11463	797	28	3	970	3	PARP4	13	25009059	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08		25009059	90160819	27	3693											
GABRB3	2562	broad.mit.edu	37	chr15	26792999	26792999	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaaaaagtgaatggaaacaCgatcctggaccatctgtcta	9	8	2	2			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr15:26792999C>T	uc001zaz.2	-	9	1505	c.1363G>A	c.(1363-1365)GTG>ATG	p.V455M	GABRB3_uc010uae.1_Missense_Mutation_p.V370M|GABRB3_uc001zba.2_Missense_Mutation_p.V455M|GABRB3_uc001zbb.2_Missense_Mutation_p.V511M	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	455	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AATGGAAACACGATCCTGGAC	0.398													T	26792999	T	T	26792999	3	4	57	1	0	0	0	0	1	0	0	0	6168	536	19	1	62	1	GABRB3	15	26792999	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08		26792999	75738393	28	3694											
UNC13C	440279	broad.mit.edu	37	chr15	54305644	54305644	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttaaaactgggagctttaCgaaaactgagaaaatggaaa	10	5	0	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr15:54305644C>T	uc002ack.2	+	1	544	c.544C>T	c.(544-546)CGA>TGA	p.R182*		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	182					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGGAGCTTTACGAAAACTGAG	0.458													T	54305644	T	T	54305644	4	4	57	1	0	0	0	0	0	1	0	0	16983	528	19	1	546	1	UNC13C	15	54305644	Nonsense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	27512645	54305644	48225748	29	3695											
IRF8	3394	broad.mit.edu	37	chr16	85952286	85952286	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagccggcagggcgtgttcGtcaagcggctgtgccagggc	18	12	1	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr16:85952286G>A	uc002fjh.2	+	7	922	c.865G>A	c.(865-867)GTC>ATC	p.V289I	IRF8_uc010chp.2_Intron	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	289					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				GGGCGTGTTCGTCAAGCGGCT	0.677													A	85952286	A	A	85952286	3	1	57	1	0	0	0	0	1	0	0	0	7836	1145	40	1	887	1	IRF8	16	85952286	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08		85952286	4402467	30	3696											
MYH2	4620	broad.mit.edu	37	chr17	10429979	10429979	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgtatttggtcctccattggGcaacctcggtgttggccttg	12	11	0	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr17:10429979G>C	uc010coi.2	-	30	4252	c.4124C>G	c.(4123-4125)GCC>GGC	p.A1375G	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.A1375G|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1375	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CCTCCATTGGGCAACCTCGGT	0.567													C	10429979	C	C	10429979	3	2	57	1	0	0	0	0	1	0	0	0	10035	1203	42	5	1745	5	MYH2	17	10429979	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08		10429979	70765231	31	3697											
NPTX1	4884	broad.mit.edu	37	chr17	78447110	78447110	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtgcccacacctggcgtggCgctggacttgagccacatgc	13	15	0	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr17:78447110C>T	uc002jyp.1	-	3	945	c.787G>A	c.(787-789)GCC>ACC	p.A263T		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	263	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			CCTGGCGTGGCGCTGGACTTG	0.587													T	78447110	T	T	78447110	3	4	57	1	0	0	0	0	1	0	0	0	10602	768	27	1	523	1	NPTX1	17	78447110	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	68017131	78447110	2748100	32	3698											
APC2	10297	broad.mit.edu	37	chr19	1465389	1465389	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgcgcaacctgctggccCatcggcccgccaagcaccag	10	20	0	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr19:1465389C>T	uc002lsr.1	+	15	2297	c.2089C>T	c.(2089-2091)CAT>TAT	p.H697Y	APC2_uc002lss.1_Missense_Mutation_p.H279Y|APC2_uc002lst.1_Missense_Mutation_p.H697Y|APC2_uc002lsu.1_Missense_Mutation_p.H696Y|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	697					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGCTGGCCCATCGGCCCGC	0.716													T	1465389	T	T	1465389	3	4	57	1	0	0	0	0	1	0	0	0	764	594	21	3	2143	3	APC2	19	1465389	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08		1465389	57663594	33	3699											
PLIN4	729359	broad.mit.edu	37	chr19	4512541	4512541	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acggcccctttggccacattCgcagcaccggtgaccccact	9	18	0	1	rs139885054	by1000genomes	TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr19:4512541C>T	uc002mar.1	-	3	1389	c.1389G>A	c.(1387-1389)GCG>GCA	p.A463A	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	463	27 X 33 AA approximate tandem repeat.|12.					lipid particle|plasma membrane					0						TGGCCACATTCGCAGCACCGG	0.577													T	4512541	T	T	4512541	2	4	57	1	0	0	0	0	0	0	0	1	12092	871	31	2		2	PLIN4	19	4512541	Silent	SNP	C	TCGA-06-0650-01A-02D-1696-08	3047152	4512541	54616442	34	3700											
CD209	30835	broad.mit.edu	37	chr19	7810925	7810925	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtcaggttctggtagatcGcgtcttgcctggattgttcc	14	9	3	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr19:7810925G>A	uc002mht.2	-	4	294	c.227C>T	c.(226-228)GCG>GTG	p.A76V	CD209_uc010xju.1_Missense_Mutation_p.A76V|CD209_uc010dvp.2_Missense_Mutation_p.A52V|CD209_uc002mhr.2_Missense_Mutation_p.A52V|CD209_uc002mhs.2_Missense_Mutation_p.A52V|CD209_uc002mhu.2_Missense_Mutation_p.A76V|CD209_uc010dvq.2_Missense_Mutation_p.A76V|CD209_uc002mhq.2_Missense_Mutation_p.A76V|CD209_uc002mhv.2_Missense_Mutation_p.A52V|CD209_uc002mhx.2_Missense_Mutation_p.A32V|CD209_uc002mhw.2_Missense_Mutation_p.A32V|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	76	Extracellular (Probable).				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						CTGGTAGATCGCGTCTTGCCT	0.458													A	7810925	A	A	7810925	3	1	57	1	0	0	0	0	1	0	0	0	2984	1087	38	1	1003	1	CD209	19	7810925	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08	3298384	7810925	51318058	35	3701											
FCGBP	8857	broad.mit.edu	37	chr19	40432968	40432968	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacatttccattacttactcCggccgcaatcagcagctgtt	7	13	1	0	rs142198641	byFrequency	TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr19:40432968C>T	uc002omp.3	-	2	1309	c.1301G>A	c.(1300-1302)CGG>CAG	p.R434Q		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	434	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TTACTTACTCCGGCCGCAATC	0.587													T	40432968	T	T	40432968	3	4	57	1	0	0	0	0	1	0	0	0	5778	652	23	2	15056	2	FCGBP	19	40432968	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	32622043	40432968	18696015	36	3702											
NLRP5	126206	broad.mit.edu	37	chr19	56539808	56539808	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtccgtatttgcggaaaattCgggtggatgtcaaagggatc	14	6	1	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr19:56539808C>T	uc002qmj.2	+	7	2209	c.2209C>T	c.(2209-2211)CGG>TGG	p.R737W	NLRP5_uc002qmi.2_Missense_Mutation_p.R718W	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	737	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCGGAAAATTCGGGTGGATGT	0.498													T	56539808	T	T	56539808	3	4	57	1	0	0	0	0	1	0	0	0	10480	875	31	2	2235	2	NLRP5	19	56539808	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08	16106840	56539808	2589175	37	3703											
TSHZ2	128553	broad.mit.edu	37	chr20	51870755	51870755	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaggacaagctcagacccaCgagctattcaaagcccagga	9	12	2	1	rs141985599		TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chr20:51870755C>T	uc002xwo.2	+	2	1714	c.758C>T	c.(757-759)ACG>ATG	p.T253M		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	253					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CTCAGACCCACGAGCTATTCA	0.488													T	51870755	T	T	51870755	3	4	57	1	0	0	0	0	1	0	0	0	16621	536	19	1	764	1	TSHZ2	20	51870755	Missense_Mutation	SNP	C	TCGA-06-0650-01A-02D-1696-08		51870755	11154765	38	3704											
GPR143	4935	broad.mit.edu	37	chrX	9711677	9711677	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatcctcctctcgttctccGtgtaaatgccttgtcttcct	5	16	3	0	rs137852297		TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chrX:9711677G>A	uc004cst.1	-	6	755	c.755C>T	c.(754-756)ACG>ATG	p.T252M		NM_000273	NP_000264	P51810	GP143_HUMAN	G protein-coupled receptor 143	232	Cytoplasmic (Potential).|Necessary for its G protein-activation ability and normal distribution of melanosomes.		T -> K (in OA1; abnormal distribution of melanosomes; Not delivered at the cell surface of melanocytic and non- melanocytic cells).		calcium-mediated signaling using intracellular calcium source|eye pigment biosynthetic process|melanosome organization|melanosome transport|phosphatidylinositol-mediated signaling|regulation of calcium-mediated signaling|visual perception	apical plasma membrane|Golgi apparatus|integral to membrane|lysosomal membrane|melanosome membrane|membrane fraction	dopamine binding|L-DOPA receptor activity|protein binding|tyrosine binding			ovary(1)	1		Hepatocellular(5;0.000888)				CTCGTTCTCCGTGTAAATGCC	0.383													A	9711677	A	A	9711677	3	1	57	1	0	0	0	0	1	0	0	0	6651	1145	40	1	535	1	GPR143	23	9711677	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08		9711677	145558883	39	3705											
WDR13	64743	broad.mit.edu	37	chrX	48463240	48463240	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctctcaccccgacagtgacGggcagtgaggacatgtgcgt	13	13	1	2	rs144018865		TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chrX:48463240G>A	uc004dkh.1	+	10	1425	c.1278G>A	c.(1276-1278)ACG>ACA	p.T426T	WDR13_uc004dki.1_Silent_p.T334T|WDR13_uc004dkj.1_Silent_p.T426T|WDR13_uc004dkk.1_Silent_p.T334T|WDR13_uc004dkl.3_Silent_p.T334T	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	426	WD 4.					cytoplasm|nucleus				ovary(2)	2						CGACAGTGACGGGCAGTGAGG	0.622													A	48463240	A	A	48463240	2	1	57	1	0	0	0	0	0	0	0	1	17272	1103	39	2		2	WDR13	23	48463240	Silent	SNP	G	TCGA-06-0650-01A-02D-1696-08	38751563	48463240	106807320	40	3706											
GRIPAP1	56850	broad.mit.edu	37	chrX	48847434	48847434	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacggcatgggggccaggacGgtgggggccgggccccctgg	21	12	0	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chrX:48847434G>A	uc004dly.1	-	7	581	c.546C>T	c.(544-546)ACC>ACT	p.T182T	GRIPAP1_uc004dlz.2_Silent_p.T72T|GRIPAP1_uc004dma.2_Silent_p.T129T	NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1	182						early endosome				breast(2)|kidney(1)	3						GGGCCAGGACGGTGGGGGCCG	0.607													A	48847434	A	A	48847434	2	1	57	1	0	0	0	0	0	0	0	1	6789	1103	39	2		2	GRIPAP1	23	48847434	Silent	SNP	G	TCGA-06-0650-01A-02D-1696-08	384194	48847434	106423126	41	3707											
FMR1NB	158521	broad.mit.edu	37	chrX	147063166	147063166	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatttggatcctgctgttcGtgtgctactacctgtcctac	8	13	0	0			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chrX:147063166G>A	uc004fcm.2	+	1	318	c.244G>A	c.(244-246)GTG>ATG	p.V82M		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	82	Helical; (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGCTGTTCGTGTGCTACTA	0.493													A	147063166	A	A	147063166	3	1	57	1	0	0	0	0	1	0	0	0	5961	1145	40	1	246	1	FMR1NB	23	147063166	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08	98215732	147063166	8207394	42	3708											
SRPK3	26576	broad.mit.edu	37	chrX	153049494	153049494	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggctgtcaccccgggggcGccagagcaggtccctcccca	13	18	1	1			TCGA-06-0650-01A-02D-1696-08	TCGA-06-0650-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	89af56db-b7f9-41d2-af62-c9b2ee7b540f	ed56d74a-781d-4408-9adc-9bfcfbe34585	g.chrX:153049494G>A	uc004fil.2	+	10	1005	c.973G>A	c.(973-975)GCC>ACC	p.A325T	SRPK3_uc004fik.2_Missense_Mutation_p.A391T|SRPK3_uc010nul.2_Intron|SRPK3_uc004fin.2_Missense_Mutation_p.A324T|SRPK3_uc004fim.2_Intron	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	325	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCCGGGGGCGCCAGAGCAGG	0.697													A	153049494	A	A	153049494	3	1	57	1	0	0	0	0	1	0	0	0	15160	1087	38	1	1011	1	SRPK3	23	153049494	Missense_Mutation	SNP	G	TCGA-06-0650-01A-02D-1696-08	5986328	153049494	2221066	43	3709											
KIAA1751	85452	broad.mit.edu	37	chr1	1896365	1896365	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggtttgctgttgaaggggcGtccttggaactcacgccccc	13	13	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr1:1896365G>A	uc001aim.1	-	13	1693	c.1537C>T	c.(1537-1539)CGC>TGC	p.R513C	KIAA1751_uc009vkz.1_Missense_Mutation_p.R513C	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	513										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TTGAAGGGGCGTCCTTGGAAC	0.662													A	1896365	A	A	1896365	3	1	58	1	0	0	0	0	1	0	0	0	8256	1145	40	1	775	1	KIAA1751	1	1896365	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08		1896365	247354256	1	3710											
RBMXL1	494115	broad.mit.edu	37	chr1	89448410	89448410	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctcttggtgctccgcggCttgaactgctgtaggaatca	11	12	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr1:89448410C>T	uc009wcx.2	-	3	1816	c.1100G>A	c.(1099-1101)AGC>AAC	p.S367N	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.S367N	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	367	Ser-rich.						nucleotide binding|RNA binding				0						TGCTCCGCGGCTTGAACTGCT	0.517													T	89448410	T	T	89448410	3	4	58	1	0	0	0	0	1	0	0	0	13153	797	28	3	76	3	RBMXL1	1	89448410	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	87552045	89448410	159802211	2	3711											
GFI1	2672	broad.mit.edu	37	chr1	92946526	92946526	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccagggccccacacggtcGgtagctctgcaccaggtgcc	12	17	1	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr1:92946526G>A	uc001dou.3	-	4	582	c.418C>T	c.(418-420)CGA>TGA	p.R140*	GFI1_uc001dov.3_Nonsense_Mutation_p.R140*|GFI1_uc001dow.3_Nonsense_Mutation_p.R140*	NM_001127215	NP_001120687	Q99684	GFI1_HUMAN	growth factor independent 1	140					negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)	1		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		CCACACGGTCGGTAGCTCTGC	0.716													A	92946526	A	A	92946526	4	1	58	1	0	0	0	0	0	1	0	0	6339	1124	39	2	866	2	GFI1	1	92946526	Nonsense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	3498116	92946526	156304095	3	3712											
DENND2C	163259	broad.mit.edu	37	chr1	115165651	115165651	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tagcgggtggtagcttccatGctgaaggggatctccacata	13	9	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr1:115165651G>T	uc001efd.1	-	6	1715	c.1013C>A	c.(1012-1014)GCA>GAA	p.A338E	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Missense_Mutation_p.A338E	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	338										skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAGCTTCCATGCTGAAGGGGA	0.343													T	115165651	T	T	115165651	3	4	58	1	0	0	0	0	1	0	0	0	4430	1319	46	5	1662	5	DENND2C	1	115165651	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	22219125	115165651	134084970	4	3713											
USH2A	7399	broad.mit.edu	37	chr1	216595737	216595737	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taaataaataatcaggcccaCgccacttgccagcaatactt	5	12	1	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr1:216595737C>T	uc001hku.1	-	2	329	c.-58G>A	c.(-60--56)GCGTG>GCATG		USH2A_uc001hkv.2_Translation_Start_Site	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B						maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATCAGGCCCACGCCACTTGCC	0.408										HNSCC(13;0.011)			T	216595737	T	T	216595737	1	4	58	1	0	0	0	0	0	0	0	0	17033	551	19	1		1	USH2A	1	216595737	Translation_Start_Site	SNP	C	TCGA-06-0686-01A-01W-0348-08	101430086	216595737	32654884	5	3714											
HHIPL2	79802	broad.mit.edu	37	chr1	222717477	222717477	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gaggcccgggagattccggaGaggcgtctgggtgttttcgg	19	8	1	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr1:222717477G>C	uc001hnh.1	-	2	434	c.376C>G	c.(376-378)CTC>GTC	p.L126V		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	126					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		AGATTCCGGAGAGGCGTCTGG	0.587													C	222717477	C	C	222717477	3	2	58	1	0	0	0	0	1	0	0	0	7094	942	33	5	1830	5	HHIPL2	1	222717477	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	6121740	222717477	26533144	6	3715											
SNAP47	116841	broad.mit.edu	37	chr1	227935725	227935725	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtcttcagcatcatcgagcaTttctggagggagctgctgct	12	10	4	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr1:227935725T>A	uc001hrf.2	+	2	837	c.423T>A	c.(421-423)CAT>CAA	p.H141Q	SNAP47_uc001hqz.2_Missense_Mutation_p.H96Q|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_Missense_Mutation_p.H141Q|SNAP47_uc001hre.2_Intron|SNAP47_uc001hrg.1_Missense_Mutation_p.H96Q	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	141						endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						TCATCGAGCATTTCTGGAGGG	0.597													A	227935725	A	A	227935725	3	1	58	1	0	0	0	0	1	0	0	0	14832	1490	52	5	429	5	SNAP47	1	227935725	Missense_Mutation	SNP	T	TCGA-06-0686-01A-01W-0348-08	5218248	227935725	21314896	7	3716											
OR6F1	343169	broad.mit.edu	37	chr1	247875632	247875632	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggagcccagggccagctgCgctgagagcaggctactcat	14	13	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr1:247875632C>T	uc001idj.1	-	1	426	c.426G>A	c.(424-426)GCG>GCA	p.A142A		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGGCCAGCTGCGCTGAGAGCA	0.597													T	247875632	T	T	247875632	2	4	58	1	0	0	0	0	0	0	0	1	11201	755	27	1		1	OR6F1	1	247875632	Silent	SNP	C	TCGA-06-0686-01A-01W-0348-08	19939907	247875632	1374989	8	3717											
ALLC	55821	broad.mit.edu	37	chr2	3727521	3727521	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccggggcttcgacgtggacGtttcttacttcacgggagat	13	10	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr2:3727521G>A	uc010ewt.2	+	5	396	c.235G>A	c.(235-237)GTT>ATT	p.V79I		NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	98							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		CGACGTGGACGTTTCTTACTT	0.532										HNSCC(21;0.051)			A	3727521	A	A	3727521	3	1	58	1	0	0	0	0	1	0	0	0	534	1145	40	1	249	1	ALLC	2	3727521	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08		3727521	239471852	9	3718											
TGFA	7039	broad.mit.edu	37	chr2	70680446	70680446	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaccactcacagtgttttcGgacctggcagcagctgcaaa	10	13	1	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr2:70680446G>A	uc002sgs.3	-	5	585	c.379C>T	c.(379-381)CGA>TGA	p.R127*	TGFA_uc010fdq.2_Nonsense_Mutation_p.R133*|TGFA_uc010fdr.2_Nonsense_Mutation_p.R132*|TGFA_uc002sgt.3_Nonsense_Mutation_p.R126*|TGFA_uc002sgu.2_Nonsense_Mutation_p.R126*|TGFA_uc002sgv.2_Nonsense_Mutation_p.R127*|TGFA_uc002sgw.2_Nonsense_Mutation_p.R126*	NM_003236	NP_003227	P01135	TGFA_HUMAN	transforming growth factor, alpha isoform 1	127	Cytoplasmic (Potential).				activation of MAPK activity|cell proliferation|positive regulation of cell division|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	cell surface|extracellular space|integral to membrane|plasma membrane	epidermal growth factor receptor binding|growth factor activity|MAP kinase kinase activity|signal transducer activity			prostate(1)	1						CAGTGTTTTCGGACCTGGCAG	0.632													A	70680446	A	A	70680446	4	1	58	1	0	0	0	0	0	1	0	0	15812	1124	39	2	111	2	TGFA	2	70680446	Nonsense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	66952925	70680446	172518927	10	3719											
CNTNAP5	129684	broad.mit.edu	37	chr2	125660583	125660583	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcgccatgccactgtcgcGcctgtgactgtccatgggac	12	15	0	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr2:125660583G>A	uc002tno.2	+	22	3922	c.3558G>A	c.(3556-3558)GCG>GCA	p.A1186A	CNTNAP5_uc010flu.2_Silent_p.A1187A	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1186	Extracellular (Potential).|Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCACTGTCGCGCCTGTGACTG	0.537													A	125660583	A	A	125660583	2	1	58	1	0	0	0	0	0	0	0	1	3650	1074	38	1		1	CNTNAP5	2	125660583	Silent	SNP	G	TCGA-06-0686-01A-01W-0348-08	54980137	125660583	117538790	11	3720											
TTN	7273	broad.mit.edu	37	chr2	179438951	179438951	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagttggccttcagccaccGtccattaggaaggtctctct	10	12	3	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr2:179438951G>A	uc010zfg.1	-	275	64428	c.64204C>T	c.(64204-64206)CGG>TGG	p.R21402W	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R15097W|TTN_uc010zfi.1_Missense_Mutation_p.R15030W|TTN_uc010zfj.1_Missense_Mutation_p.R14905W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22329							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R21402C(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGCCACCGTCCATTAGGA	0.413													A	179438951	A	A	179438951	3	1	58	1	0	0	0	0	1	0	0	0	16732	1144	40	1	36219	1	TTN	2	179438951	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	53778368	179438951	63760422	12	3721											
TTN	7273	broad.mit.edu	37	chr2	179569359	179569359	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caccatcaatgcttatttcaAatttatcactgggttccagt	5	10	3	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr2:179569359A>C	uc010zfg.1	-	102	26332	c.26108T>G	c.(26107-26109)TTT>TGT	p.F8703C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.F5364C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9630							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTATTTCAAATTTATCACT	0.368													C	179569359	C	C	179569359	3	2	58	1	0	0	0	0	1	0	0	0	16732	14	1	5	74721	5	TTN	2	179569359	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	130408	179569359	63630014	13	3722											
ALPPL2	251	broad.mit.edu	37	chr2	233272379	233272379	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcggggtcaagggcaacTtccagaccattggcttgagt	14	9	1	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr2:233272379T>C	uc002vss.3	+	4	429	c.376T>C	c.(376-378)TTC>CTC	p.F126L		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	126					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CAAGGGCAACTTCCAGACCAT	0.582													C	233272379	C	C	233272379	3	2	58	1	0	0	0	0	1	0	0	0	549	1609	56	4	390	4	ALPPL2	2	233272379	Missense_Mutation	SNP	T	TCGA-06-0686-01A-01W-0348-08	53703020	233272379	9926994	14	3723											
CRELD1	78987	broad.mit.edu	37	chr3	9982660	9982660	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaggcctgtggccagtgtgGccttggctactttgaggcag	16	9	0	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr3:9982660G>A	uc003bug.2	+	6	705	c.587G>A	c.(586-588)GGC>GAC	p.G196D	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Missense_Mutation_p.G196D|CRELD1_uc003buh.2_Missense_Mutation_p.G196D|CRELD1_uc003bui.2_Missense_Mutation_p.G196D|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	196	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						GGCCAGTGTGGCCTTGGCTAC	0.642													A	9982660	A	A	9982660	3	1	58	1	0	0	0	0	1	0	0	0	3866	1203	42	3	605	3	CRELD1	3	9982660	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08		9982660	188039770	15	3724											
PLS1	5357	broad.mit.edu	37	chr3	142383125	142383125	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctcgggaggagcttgaagaaCtacaagaggcatttaataaa	11	6	0	3			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr3:142383125C>G	uc010huv.2	+	2	205	c.46C>G	c.(46-48)CTA>GTA	p.L16V	PLS1_uc003euz.2_Missense_Mutation_p.L16V|PLS1_uc003eva.2_Missense_Mutation_p.L16V	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	16	EF-hand 1.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						GCTTGAAGAACTACAAGAGGC	0.333													G	142383125	G	G	142383125	3	3	58	1	0	0	0	0	1	0	0	0	12107	564	20	5	48	5	PLS1	3	142383125	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	132400465	142383125	55639305	16	3725											
GHSR	2693	broad.mit.edu	37	chr3	172165997	172165997	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcgcagctcgcggaagcgCgacaccaccagcatggtgag	15	13	0	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr3:172165997C>T	uc003fib.1	-	1	207	c.207G>A	c.(205-207)TCG>TCA	p.S69S	GHSR_uc011bpv.1_Silent_p.S69S	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	69	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CGCGGAAGCGCGACACCACCA	0.657													T	172165997	T	T	172165997	2	4	58	1	0	0	0	0	0	0	0	1	6375	755	27	1		1	GHSR	3	172165997	Silent	SNP	C	TCGA-06-0686-01A-01W-0348-08	29782872	172165997	25856433	17	3726											
FRYL	285527	broad.mit.edu	37	chr4	48503638	48503638	+	Splice_Site	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctaatacaactgaatatttAcctctgcttcattttttatc	2	10	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr4:48503638A>C	uc003gyh.1	-	62	9197	c.8592_splice	c.e62+1	p.E2864_splice	FRYL_uc003gye.1_Splice_Site_p.E46_splice|FRYL_uc003gyf.1_Splice_Site_p.E254_splice|FRYL_uc003gyg.1_Splice_Site_p.E1554_splice	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CTGAATATTTACCTCTGCTTC	0.294													C	48503638	C	C	48503638	5	2	58	1	0	0	0	0	0	0	1	0	6064	405	14	5	459	5	FRYL	4	48503638	Splice_Site	SNP	A	TCGA-06-0686-01A-01W-0348-08		48503638	142650638	18	3727											
FRYL	285527	broad.mit.edu	37	chr4	48537846	48537846	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atttttcttctgcacaaaccTagaaaacaaataaaattatt	2	7	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr4:48537846T>C	uc003gyh.1	-	48	6999	c.6394_splice	c.e48-1	p.V2132_splice	FRYL_uc003gyg.1_Splice_Site_p.V828_splice|FRYL_uc003gyi.1_Splice_Site_p.V1020_splice|FRYL_uc003gyj.1_Splice_Site_p.V427_splice	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TGCACAAACCTAGAAAACAAA	0.318													C	48537846	C	C	48537846	5	2	58	1	0	0	0	0	0	0	1	0	6064	1536	53	4	2717	4	FRYL	4	48537846	Splice_Site	SNP	T	TCGA-06-0686-01A-01W-0348-08	34208	48537846	142616430	19	3728											
NPY5R	4889	broad.mit.edu	37	chr4	164272650	164272650	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atttcaagttggtgtattgcAtttgtcatttgttgggcatg	11	4	2	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr4:164272650A>G	uc003iqn.2	+	4	1407	c.1225A>G	c.(1225-1227)ATT>GTT	p.I409V		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	409	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				GGTGTATTGCATTTGTCATTT	0.348													G	164272650	G	G	164272650	3	3	58	1	0	0	0	0	1	0	0	0	10610	217	8	4	1227	4	NPY5R	4	164272650	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	115734804	164272650	26881626	20	3729											
TRIML1	339976	broad.mit.edu	37	chr4	189065255	189065255	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgagtctgtgccgcatcaCgggaatgaaggagatgctaa	14	8	2	3			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr4:189065255C>T	uc003izm.1	+	5	939	c.824C>T	c.(823-825)ACG>ATG	p.T275M	TRIML1_uc003izn.1_Translation_Start_Site	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	275	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding	p.T275T(1)		ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TGCCGCATCACGGGAATGAAG	0.527													T	189065255	T	T	189065255	3	4	58	1	0	0	0	0	1	0	0	0	16547	536	19	1	842	1	TRIML1	4	189065255	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	24792605	189065255	2089021	21	3730											
CTNND2	1501	broad.mit.edu	37	chr5	11082954	11082954	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cagcggctcggatatatactGaccactgcaaaaacagggaa	10	10	0	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr5:11082954G>A	uc003jfa.1	-	16	2787	c.2642C>T	c.(2641-2643)TCA>TTA	p.S881L	CTNND2_uc010itt.2_Missense_Mutation_p.S790L|CTNND2_uc011cmy.1_Missense_Mutation_p.S544L|CTNND2_uc011cmz.1_Missense_Mutation_p.S448L|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.S473L	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	881					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GATATATACTGACCACTGCAA	0.537													A	11082954	A	A	11082954	3	1	58	1	0	0	0	0	1	0	0	0	4020	1294	45	3	1063	3	CTNND2	5	11082954	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08		11082954	169832306	22	3731											
AP3B1	8546	broad.mit.edu	37	chr5	77311333	77311333	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaaattctgtggtgcagcaAtgattacagcagaagtttca	10	6	2	3			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr5:77311333A>G	uc003kfj.2	-	26	3157	c.3032T>C	c.(3031-3033)ATT>ACT	p.I1011T		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	1011					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TGGTGCAGCAATGATTACAGC	0.383									Hermansky-Pudlak_syndrome				G	77311333	G	G	77311333	3	3	58	1	0	0	0	0	1	0	0	0	744	101	4	4	260	4	AP3B1	5	77311333	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	66228379	77311333	103603927	23	3732											
GPR150	285601	broad.mit.edu	37	chr5	94956705	94956705	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaggccgtcgcgggcttcgtCgcgcctgttacggtcctggg	17	13	0	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr5:94956705C>T	uc003kle.1	+	1	726	c.726C>T	c.(724-726)GTC>GTT	p.V242V		NM_199243	NP_954713	Q8NGU9	GP150_HUMAN	G protein-coupled receptor 150	242	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(142;0.000462)|all_epithelial(76;2.44e-06)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)		all cancers(79;1.82e-16)		CGGGCTTCGTCGCGCCTGTTA	0.682													T	94956705	T	T	94956705	2	4	58	1	0	0	0	0	0	0	0	1	6656	871	31	2		2	GPR150	5	94956705	Silent	SNP	C	TCGA-06-0686-01A-01W-0348-08	17645372	94956705	85958555	24	3733											
PPIC	5480	broad.mit.edu	37	chr5	122359634	122359634	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcttgccactgttgatgatcGagcagttggtgagtggacgg	15	7	1	3			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr5:122359634G>A	uc003kth.2	-	5	680	c.575C>T	c.(574-576)TCG>TTG	p.S192L		NM_000943	NP_000934	P45877	PPIC_HUMAN	peptidylprolyl isomerase C	192	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			ovary(1)	1		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	GTTGATGATCGAGCAGTTGGT	0.478													A	122359634	A	A	122359634	3	1	58	1	0	0	0	0	1	0	0	0	12320	1059	37	2	67	2	PPIC	5	122359634	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	27402929	122359634	58555626	25	3734											
SLC12A2	6558	broad.mit.edu	37	chr5	127520072	127520072	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttaaagtattatagcttttgAggaaatcattgagccataca	7	5	1	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr5:127520072A>G	uc003kus.2	+	25	3478	c.3314A>G	c.(3313-3315)GAG>GGG	p.E1105G	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.E1089G	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	1105	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	ATAGCTTTTGAGGAAATCATT	0.289													G	127520072	G	G	127520072	3	3	58	1	0	0	0	0	1	0	0	0	14383	304	11	4	3412	4	SLC12A2	5	127520072	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	5160438	127520072	53395188	26	3735											
PCDHA13	56136	broad.mit.edu	37	chr5	140263877	140263877	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctggtggagagcggccaagCgccacaggcttcgtcgaggg	18	11	0	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr5:140263877C>T	uc003lif.2	+	1	2024	c.2024C>T	c.(2023-2025)GCG>GTG	p.A675V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.A675V|PCDHA13_uc003lid.2_Missense_Mutation_p.A675V	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	675	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A675V(1)		ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGGCCAAGCGCCACAGGCT	0.662													T	140263877	T	T	140263877	3	4	58	1	0	0	0	0	1	0	0	0	11523	768	27	1	2026	1	PCDHA13	5	140263877	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	12743805	140263877	40651383	27	3736											
PDGFRB	5159	broad.mit.edu	37	chr5	149503887	149503887	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gactcatgatcttcagctccGacataagggcttgcttctca	8	12	4	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr5:149503887G>A	uc003lro.2	-	14	2418	c.1949C>T	c.(1948-1950)TCG>TTG	p.S650L	PDGFRB_uc010jhd.2_Missense_Mutation_p.S489L	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	650	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTTCAGCTCCGACATAAGGGC	0.637			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								A	149503887	A	A	149503887	3	1	58	1	0	0	0	0	1	0	0	0	11662	1059	37	2	1411	2	PDGFRB	5	149503887	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	9240010	149503887	31411373	28	3737											
GABRG2	2566	broad.mit.edu	37	chr5	161520964	161520964	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctggaaggatatgacaatAaacttcggcctgatatagga	11	6	0	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr5:161520964A>G	uc003lyz.3	+	2	596	c.238A>G	c.(238-240)AAA>GAA	p.K80E	GABRG2_uc010jjc.2_Missense_Mutation_p.K80E|GABRG2_uc003lyy.3_Missense_Mutation_p.K80E|GABRG2_uc011dej.1_Translation_Start_Site	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	80	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		ATATGACAATAAACTTCGGCC	0.373													G	161520964	G	G	161520964	3	3	58	1	0	0	0	0	1	0	0	0	6172	363	13	4	244	4	GABRG2	5	161520964	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	12017077	161520964	19394296	29	3738											
GRM6	2916	broad.mit.edu	37	chr5	178415969	178415969	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctcgaatgtactgcagaaGcatccgcccatcagtgggtt	11	11	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr5:178415969G>A	uc003mjr.2	-	6	1500	c.1321C>T	c.(1321-1323)CTT>TTT	p.L441F	GRM6_uc010jla.1_Missense_Mutation_p.L24F|GRM6_uc003mjs.1_Missense_Mutation_p.L61F	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	441	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TACTGCAGAAGCATCCGCCCA	0.642													A	178415969	A	A	178415969	3	1	58	1	0	0	0	0	1	0	0	0	6801	971	34	3	1332	3	GRM6	5	178415969	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	16895005	178415969	2499291	30	3739											
ZNF184	7738	broad.mit.edu	37	chr6	27420960	27420960	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctcttttgtgtttttccacTattacctctggagatagctc	6	10	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr6:27420960T>G	uc003njj.2	-	5	1189	c.378A>C	c.(376-378)ATA>ATC	p.I126I	ZNF184_uc010jqv.2_Silent_p.I126I|ZNF184_uc003nji.2_Silent_p.I126I	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTTTTTCCACTATTACCTCTG	0.413													G	27420960	G	G	27420960	2	3	58	1	0	0	0	0	0	0	0	1	17748	1512	53	5		5	ZNF184	6	27420960	Silent	SNP	T	TCGA-06-0686-01A-01W-0348-08		27420960	143694107	31	3740											
OR2H1	26716	broad.mit.edu	37	chr6	29430405	29430405	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccttcacttaaccctctcGtatacaccctgaggaacaag	5	15	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr6:29430405G>A	uc003nmi.2	+	3	1302	c.859G>A	c.(859-861)GTA>ATA	p.V287I	OR2H1_uc003nmj.1_Missense_Mutation_p.V287I|OR2H1_uc010jri.1_Missense_Mutation_p.V209I	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TAACCCTCTCGTATACACCCT	0.493													A	29430405	A	A	29430405	3	1	58	1	0	0	0	0	1	0	0	0	11001	1145	40	1	861	1	OR2H1	6	29430405	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	2009445	29430405	141684662	32	3741											
SUN3	256979	broad.mit.edu	37	chr7	48035742	48035742	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccagcttcaatgatggaggcTcctaaaattataaagtaagt	8	7	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr7:48035742T>A	uc003tof.2	-	8	676	c.579A>T	c.(577-579)GGA>GGT	p.G193G	SUN3_uc010kyq.2_Silent_p.G93G|SUN3_uc003tog.2_Silent_p.G193G|SUN3_uc011kcf.1_Silent_p.G181G	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	193	SUN.					integral to membrane				central_nervous_system(1)	1						TGATGGAGGCTCCTAAAATTA	0.313													A	48035742	A	A	48035742	2	1	58	1	0	0	0	0	0	0	0	1	15390	1565	54	5		5	SUN3	7	48035742	Silent	SNP	T	TCGA-06-0686-01A-01W-0348-08		48035742	111102921	33	3742											
ADAM22	53616	broad.mit.edu	37	chr7	87704970	87704970	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gtcctctgaatacatagagaGacacattgaacatggaggca	10	8	1	4			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr7:87704970G>A	uc003ujn.2	+	4	432	c.353G>A	c.(352-354)AGA>AAA	p.R118K	ADAM22_uc003uji.1_Missense_Mutation_p.R117K|ADAM22_uc003ujj.1_Missense_Mutation_p.R118K|ADAM22_uc003ujk.1_Missense_Mutation_p.R118K|ADAM22_uc003ujl.1_Missense_Mutation_p.R118K|ADAM22_uc003ujm.2_Missense_Mutation_p.R118K|ADAM22_uc003ujo.2_Missense_Mutation_p.R118K|ADAM22_uc003ujp.1_Missense_Mutation_p.R170K	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	118					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TACATAGAGAGACACATTGAA	0.338													A	87704970	A	A	87704970	3	1	58	1	0	0	0	0	1	0	0	0	244	942	33	3	367	3	ADAM22	7	87704970	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	39669228	87704970	71433693	34	3743											
SAMD9L	219285	broad.mit.edu	37	chr7	92764397	92764397	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aatctgtcagatggtgtattGttctgcagaaggacttccac	10	8	3	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr7:92764397G>T	uc003umh.1	-	5	2104	c.888C>A	c.(886-888)AAC>AAA	p.N296K	SAMD9L_uc003umj.1_Missense_Mutation_p.N296K|SAMD9L_uc003umi.1_Missense_Mutation_p.N296K|SAMD9L_uc010lfb.1_Missense_Mutation_p.N296K|SAMD9L_uc003umk.1_Missense_Mutation_p.N296K|SAMD9L_uc010lfc.1_Missense_Mutation_p.N296K|SAMD9L_uc010lfd.1_Missense_Mutation_p.N296K|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	296										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			ATGGTGTATTGTTCTGCAGAA	0.338													T	92764397	T	T	92764397	3	4	58	1	0	0	0	0	1	0	0	0	13827	1368	48	5	3870	5	SAMD9L	7	92764397	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	5059427	92764397	66374266	35	3744											
AZGP1	563	broad.mit.edu	37	chr7	99564649	99564649	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gctggcctcccagggcaccaCgaggggctgggccaggctgc	17	15	0	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr7:99564649C>G	uc003ush.2	-	4	918	c.874G>C	c.(874-876)GTG>CTG	p.V292L		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	292	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CAGGGCACCACGAGGGGCTGG	0.637													G	99564649	G	G	99564649	3	3	58	1	0	0	0	0	1	0	0	0	1239	536	19	5	26	5	AZGP1	7	99564649	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	6800252	99564649	59574014	36	3745											
TRPV6	55503	broad.mit.edu	37	chr7	142572331	142572331	+	Frame_Shift_Del	DEL	G	-	-													cagcccagcacgagtgcaaaGgacatgggtaccacctcccc							TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr7:142572331delG	uc003wbx.1	-	11	1581	c.1365delC	c.(1363-1365)TCCfs	p.S455fs	TRPV6_uc003wbw.1_Frame_Shift_Del_p.S241fs|TRPV6_uc010lou.1_Frame_Shift_Del_p.S326fs	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	455	Helical; (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CGAGTGCAAAGGACATGGGTA	0.592													-	142572331	-	-	142572331	7	5	58	1	0	1	0	1	0	0	0	0	16597	987	35	0	832	0	TRPV6	7	142572331	Frame_Shift_Del	DEL	G	TCGA-06-0686-01A-01W-0348-08	43007682	142572331	16566332	37	3746											
ARHGEF10	9639	broad.mit.edu	37	chr8	1808147	1808147	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gatgaaagtcaacccatattCtgtcatcgacatcacgccat	6	12	4	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr8:1808147C>T	uc003wpr.2	+	4	456	c.278C>T	c.(277-279)TCT>TTT	p.S93F	ARHGEF10_uc003wpq.1_Missense_Mutation_p.S117F|ARHGEF10_uc003wps.2_Missense_Mutation_p.S93F|ARHGEF10_uc003wpt.2_Missense_Mutation_p.S7F|ARHGEF10_uc010lrd.1_Missense_Mutation_p.S7F|ARHGEF10_uc003wpu.2_Missense_Mutation_p.S7F	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	117					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		AACCCATATTCTGTCATCGAC	0.597													T	1808147	T	T	1808147	3	4	58	1	0	0	0	0	1	0	0	0	894	913	32	3	288	3	ARHGEF10	8	1808147	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08		1808147	144555875	38	3747											
CHD7	55636	broad.mit.edu	37	chr8	61769309	61769309	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgctccaagcaggcctttcGcgcacacccacaaggcatct	8	17	1	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr8:61769309G>A	uc003xue.2	+	34	7947	c.7470G>A	c.(7468-7470)TCG>TCA	p.S2490S		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2490					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CAGGCCTTTCGCGCACACCCA	0.483													A	61769309	A	A	61769309	2	1	58	1	0	0	0	0	0	0	0	1	3330	1074	38	1		1	CHD7	8	61769309	Silent	SNP	G	TCGA-06-0686-01A-01W-0348-08	59961162	61769309	84594713	39	3748											
C8orf34	116328	broad.mit.edu	37	chr8	69621313	69621313	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaaaaaatcccagattcattCggtaagttttaagtccaaca	6	8	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr8:69621313C>T	uc010lyz.2	+	9	1117	c.1068C>T	c.(1066-1068)TTC>TTT	p.F356F	C8orf34_uc003xyb.2_Silent_p.F331F	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	356					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CAGATTCATTCGGTAAGTTTT	0.343													T	69621313	T	T	69621313	2	4	58	1	0	0	0	0	0	0	0	1	2422	898	31	2		2	C8orf34	8	69621313	Silent	SNP	C	TCGA-06-0686-01A-01W-0348-08	7852004	69621313	76742709	40	3749											
KCNB2	9312	broad.mit.edu	37	chr8	73849588	73849588	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgctgccagggatggcacGctggagtatgccccagttga	14	12	0	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr8:73849588G>A	uc003xzb.2	+	3	2586	c.1998G>A	c.(1996-1998)ACG>ACA	p.T666T		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	666	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GGGATGGCACGCTGGAGTATG	0.567													A	73849588	A	A	73849588	2	1	58	1	0	0	0	0	0	0	0	1	8013	1074	38	1		1	KCNB2	8	73849588	Silent	SNP	G	TCGA-06-0686-01A-01W-0348-08	4228275	73849588	72514434	41	3750											
CCNE2	9134	broad.mit.edu	37	chr8	95900206	95900206	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attccaatgagttgaagcatAtttttatttatatccttttg	5	5	0	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr8:95900206A>C	uc003yhc.2	-	7	658	c.549T>G	c.(547-549)AAT>AAG	p.N183K	CCNE2_uc003yhd.2_Missense_Mutation_p.N183K	NM_057749	NP_477097	O96020	CCNE2_HUMAN	cyclin E2	183					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding				0	Breast(36;8.75e-07)					GTTGAAGCATATTTTTATTTA	0.284													C	95900206	C	C	95900206	3	2	58	1	0	0	0	0	1	0	0	0	2921	446	16	5	689	5	CCNE2	8	95900206	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	22050618	95900206	50463816	42	3751											
ENPP2	5168	broad.mit.edu	37	chr8	120569830	120569830	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tctgggtagctgcggctggtCtttcggaagaagtccaggct	15	9	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr8:120569830C>T	uc003yot.1	-	25	2609	c.2523G>A	c.(2521-2523)AAG>AAA	p.K841K	ENPP2_uc011lic.1_Silent_p.K379K|ENPP2_uc003yor.1_Silent_p.K476K|ENPP2_uc003yos.1_Silent_p.K893K|ENPP2_uc010mdd.1_Silent_p.K866K	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	841	Required for secretion (By similarity).				cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGCGGCTGGTCTTTCGGAAGA	0.468													T	120569830	T	T	120569830	2	4	58	1	0	0	0	0	0	0	0	1	5130	912	32	3		3	ENPP2	8	120569830	Silent	SNP	C	TCGA-06-0686-01A-01W-0348-08	24669624	120569830	25794192	43	3752											
COL14A1	7373	broad.mit.edu	37	chr8	121326187	121326187	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagggaccagatggccctcGgggtgaaattggtctgccag	15	11	1	2	rs142082215		TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr8:121326187G>A	uc003yox.2	+	38	4737	c.4472G>A	c.(4471-4473)CGG>CAG	p.R1491Q	COL14A1_uc003yoz.2_Missense_Mutation_p.R456Q	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1491	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GATGGCCCTCGGGGTGAAATT	0.468													A	121326187	A	A	121326187	3	1	58	1	0	0	0	0	1	0	0	0	3671	1116	39	2	4618	2	COL14A1	8	121326187	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	756357	121326187	25037835	44	3753											
COL22A1	169044	broad.mit.edu	37	chr8	139606377	139606377	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tccagggggccctgggggccCaggtctgccttgagatgact	16	12	1	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr8:139606377C>A	uc003yvd.2	-	63	4945	c.4498G>T	c.(4498-4500)GGG>TGG	p.G1500W	COL22A1_uc011ljo.1_Missense_Mutation_p.G780W	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1500	Pro-rich.|Gly-rich.|Collagen-like 15.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCTGGGGGCCCAGGTCTGCCT	0.632										HNSCC(7;0.00092)			A	139606377	A	A	139606377	3	1	58	1	0	0	0	0	1	0	0	0	3681	594	21	5	394	5	COL22A1	8	139606377	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	18280190	139606377	6757645	45	3754											
IL15RA	3601	broad.mit.edu	37	chr10	5995110	5995110	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	catctctgctgctggtccccCaagtcaccggcagagcctcc	9	18	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr10:5995110C>A	uc001iiv.2	-	7	834	c.752G>T	c.(751-753)TGG>TTG	p.W251L	IL15RA_uc001iiu.2_Intron|IL15RA_uc010qau.1_Missense_Mutation_p.W218L|IL15RA_uc001iiw.2_Missense_Mutation_p.W215L|IL15RA_uc001iix.2_Missense_Mutation_p.W182L|IL15RA_uc001iiy.2_Missense_Mutation_p.W99L	NM_002189	NP_002180	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha isoform 1	251	Cytoplasmic (Potential).				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity				0						GCTGGTCCCCCAAGTCACCGG	0.557													A	5995110	A	A	5995110	3	1	58	1	0	0	0	0	1	0	0	0	7632	595	21	5	55	5	IL15RA	10	5995110	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08		5995110	129539637	46	3755											
AGAP6	414189	broad.mit.edu	37	chr10	51754173	51754173	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agttgtagaaataagaagaaGcaactgtacaaaccatgtaa	8	5	0	3			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr10:51754173G>T	uc001jix.3	+	4	778	c.380G>T	c.(379-381)AGC>ATC	p.S127I		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	127					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						ATAAGAAGAAGCAACTGTACA	0.269													T	51754173	T	T	51754173	3	4	58	1	0	0	0	0	1	0	0	0	372	971	34	5	394	5	AGAP6	10	51754173	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	45759063	51754173	83780574	47	3756											
DUSP13	51207	broad.mit.edu	37	chr10	76867879	76867879	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgccgtagaagtcagggcCgccctgacagtagaggccct	14	13	1	3			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr10:76867879C>T	uc001jws.2	-	2	293	c.238G>A	c.(238-240)GGC>AGC	p.G80S	DUSP13_uc001jwu.2_Intron|DUSP13_uc001jww.2_Intron|DUSP13_uc009xrs.2_5'UTR|DUSP13_uc001jwt.2_5'UTR|DUSP13_uc001jwv.2_Intron	NM_001007271	NP_001007272	Q6B8I1	MDSP_HUMAN	muscle-restricted dual specificity phosphatase	80	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					AAGTCAGGGCCGCCCTGACAG	0.622													T	76867879	T	T	76867879	3	4	58	1	0	0	0	0	1	0	0	0	4813	652	23	2	1232	2	DUSP13	10	76867879	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	25113706	76867879	58666868	48	3757											
MUC2	4583	broad.mit.edu	37	chr11	1078153	1078153	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcctctgcggggactacaacGgcctgcagagctattcagaa	12	12	2	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr11:1078153G>T	uc001lsx.1	+	4	547	c.520G>T	c.(520-522)GGC>TGC	p.G174C		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	174	VWFD 1.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GGACTACAACGGCCTGCAGAG	0.667													T	1078153	T	T	1078153	3	4	58	1	0	0	0	0	1	0	0	0	9975	1116	39	5	534	5	MUC2	11	1078153	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08		1078153	133928363	49	3758											
UBQLN3	50613	broad.mit.edu	37	chr11	5529867	5529867	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acctgagcctccatgtgtggAagtccaggggttggggagag	17	8	0	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr11:5529867A>T	uc001may.1	-	2	1008	c.922T>A	c.(922-924)TCC>ACC	p.S308T	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	308										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCATGTGTGGAAGTCCAGGGG	0.517													T	5529867	T	T	5529867	3	4	58	1	0	0	0	0	1	0	0	0	16895	246	9	5	1049	5	UBQLN3	11	5529867	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	4451714	5529867	129476649	50	3759											
GYLTL1B	120071	broad.mit.edu	37	chr11	45946107	45946107	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tactccggcctctatgggctAatgaagctggtgctgcccag	12	12	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr11:45946107A>C	uc001nbv.1	+	5	654	c.543A>C	c.(541-543)CTA>CTC	p.L181L	GYLTL1B_uc001nbw.1_Silent_p.L150L|GYLTL1B_uc001nbx.1_Silent_p.L181L|GYLTL1B_uc001nby.1_5'Flank	NM_152312	NP_689525	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	181	Lumenal (Potential).				muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.226)		TCTATGGGCTAATGAAGCTGG	0.612													C	45946107	C	C	45946107	2	2	58	1	0	0	0	0	0	0	0	1	6907	349	13	5		5	GYLTL1B	11	45946107	Silent	SNP	A	TCGA-06-0686-01A-01W-0348-08	40416240	45946107	89060409	51	3760											
OR4S2	219431	broad.mit.edu	37	chr11	55419288	55419288	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aagaaactgtggggcagaaaTgttttcttggaggctaaagg	14	4	1	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr11:55419288T>A	uc001nhs.1	+	1	909	c.909T>A	c.(907-909)AAT>AAA	p.N303K		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	303	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				GGGGCAGAAATGTTTTCTTGG	0.274													A	55419288	A	A	55419288	3	1	58	1	0	0	0	0	1	0	0	0	11083	1461	51	5	911	5	OR4S2	11	55419288	Missense_Mutation	SNP	T	TCGA-06-0686-01A-01W-0348-08	9473181	55419288	79587228	52	3761											
MRE11A	4361	broad.mit.edu	37	chr11	94192689	94192689	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catctttctcctccttgtccAcaaattcttgtactgcttca	3	14	4	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr11:94192689A>T	uc001peu.2	-	13	1574	c.1385T>A	c.(1384-1386)GTG>GAG	p.V462E	MRE11A_uc001pev.2_Missense_Mutation_p.V462E|MRE11A_uc009ywj.2_Missense_Mutation_p.V465E	NM_005591	NP_005582	P49959	MRE11_HUMAN	meiotic recombination 11 homolog A isoform 1	462					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				CTCCTTGTCCACAAATTCTTG	0.398								Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				T	94192689	T	T	94192689	3	4	58	1	0	0	0	0	1	0	0	0	9759	159	6	5	773	5	MRE11A	11	94192689	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	38773401	94192689	40813827	53	3762											
PIWIL4	143689	broad.mit.edu	37	chr11	94328516	94328516	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgatttccagctgatgaagGctgtggctgaaaagacacgt	12	8	0	5			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr11:94328516G>A	uc001pfa.2	+	10	1403	c.1192G>A	c.(1192-1194)GCT>ACT	p.A398T	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	398					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GCTGATGAAGGCTGTGGCTGA	0.502													A	94328516	A	A	94328516	3	1	58	1	0	0	0	0	1	0	0	0	11960	1203	42	3	1230	3	PIWIL4	11	94328516	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	135827	94328516	40678000	54	3763											
INHBE	83729	broad.mit.edu	37	chr12	57849443	57849443	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	caccccaagcagaacgagctCtggtgctggagctagccaag	12	13	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr12:57849443C>G	uc001snw.2	+	1	348	c.124C>G	c.(124-126)CTG>GTG	p.L42V		NM_031479	NP_113667	P58166	INHBE_HUMAN	activin beta E precursor	42					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)	3						AGAACGAGCTCTGGTGCTGGA	0.622													G	57849443	G	G	57849443	3	3	58	1	0	0	0	0	1	0	0	0	7744	912	32	5	126	5	INHBE	12	57849443	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08		57849443	76002452	55	3764											
KCNRG	283518	broad.mit.edu	37	chr13	50589662	50589662	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaactggtcactttgaatgtGggagggaagatattcacgac	13	6	2	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr13:50589662G>C	uc001vdu.2	+	1	273	c.33G>C	c.(31-33)GTG>GTC	p.V11V	DLEU2_uc001vdn.1_Intron|DLEU2_uc001vdo.1_Intron|KCNRG_uc001vdt.2_Silent_p.V11V|TRIM13_uc001vdp.1_3'UTR|TRIM13_uc001vdq.1_3'UTR|TRIM13_uc001vdr.1_3'UTR|TRIM13_uc001vds.1_3'UTR	NM_173605	NP_775876	Q8N5I3	KCNRG_HUMAN	potassium channel regulator isoform 1	11	BTB.					voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity				0		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.48e-10)|COAD - Colon adenocarcinoma(199;0.204)		CTTTGAATGTGGGAGGGAAGA	0.433													C	50589662	C	C	50589662	2	2	58	1	0	0	0	0	0	0	0	1	8087	1335	47	5		5	KCNRG	13	50589662	Silent	SNP	G	TCGA-06-0686-01A-01W-0348-08		50589662	64580216	56	3765											
NEK3	4752	broad.mit.edu	37	chr13	52715184	52715184	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgcttcatttcccaaagctAtcctgattctgctggggttt	8	10	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr13:52715184A>G	uc001vgi.2	-	13	1134	c.899T>C	c.(898-900)ATA>ACA	p.I300T	NEK3_uc001vgg.2_Intron|NEK3_uc001vgh.2_Intron|NEK3_uc010tgx.1_RNA|NEK3_uc010tgy.1_Intron	NM_152720	NP_689933	P51956	NEK3_HUMAN	NIMA-related kinase 3 isoform a	300					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		TCCCAAAGCTATCCTGATTCT	0.323													G	52715184	G	G	52715184	3	3	58	1	0	0	0	0	1	0	0	0	10325	449	16	4	645	4	NEK3	13	52715184	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	2125522	52715184	62454694	57	3766											
CTSG	1511	broad.mit.edu	37	chr14	25043567	25043567	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactctcagctgcacctctcGgagtgtatctgttcccctcc	7	17	3	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr14:25043567G>A	uc001wpq.2	-	4	515	c.478C>T	c.(478-480)CGA>TGA	p.R160*		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	160	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		TGCACCTCTCGGAGTGTATCT	0.642													A	25043567	A	A	25043567	4	1	58	1	0	0	0	0	0	1	0	0	4035	1124	39	2	297	2	CTSG	14	25043567	Nonsense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08		25043567	82305973	58	3767											
CLMN	79789	broad.mit.edu	37	chr14	95669370	95669370	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctctgagagccatcggcctcCtcctccctggagtccaggtc	10	17	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr14:95669370C>G	uc001yef.2	-	9	2432	c.2316G>C	c.(2314-2316)GAG>GAC	p.E772D		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	772						integral to membrane	actin binding				0				Epithelial(152;0.193)		CATCGGCCTCCTCCTCCCTGG	0.567													G	95669370	G	G	95669370	3	3	58	1	0	0	0	0	1	0	0	0	3542	680	24	5	712	5	CLMN	14	95669370	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	70625803	95669370	11680170	59	3768											
HHIPL1	84439	broad.mit.edu	37	chr14	100118755	100118755	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggttctgccgctacctgtcCctggatgacacggactactg	11	13	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr14:100118755C>T	uc010avs.2	+	2	515	c.450C>T	c.(448-450)TCC>TCT	p.S150S	HHIPL1_uc001ygl.1_Silent_p.S150S	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	150					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				GCTACCTGTCCCTGGATGACA	0.602													T	100118755	T	T	100118755	2	4	58	1	0	0	0	0	0	0	0	1	7093	610	22	3		3	HHIPL1	14	100118755	Silent	SNP	C	TCGA-06-0686-01A-01W-0348-08	4449385	100118755	7230785	60	3769											
ZNF609	23060	broad.mit.edu	37	chr15	64966530	64966530	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagaaactgcccctcccccGtcctaattgactgtccccac	5	19	0	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr15:64966530G>A	uc002ann.2	+	4	1477	c.1477G>A	c.(1477-1479)GTC>ATC	p.V493I		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	493						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCCCTCCCCCGTCCTAATTGA	0.522													A	64966530	A	A	64966530	3	1	58	1	0	0	0	0	1	0	0	0	18032	1145	40	1	1491	1	ZNF609	15	64966530	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08		64966530	37564862	61	3770											
ISLR	3671	broad.mit.edu	37	chr15	74468444	74468444	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccccaggcctgctcctgctGggccaaagcctcctcctctt	8	20	1	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr15:74468444G>C	uc002axg.1	+	2	1527	c.1245G>C	c.(1243-1245)CTG>CTC	p.L415L	ISLR_uc002axh.1_Silent_p.L415L	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	415					cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TGCTCCTGCTGGGCCAAAGCC	0.617													C	74468444	C	C	74468444	2	2	58	1	0	0	0	0	0	0	0	1	7858	1335	47	5		5	ISLR	15	74468444	Silent	SNP	G	TCGA-06-0686-01A-01W-0348-08	9501914	74468444	28062948	62	3771											
ARNT2	9915	broad.mit.edu	37	chr15	80845010	80845010	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tctcctgtatgcatggacatGaatgggatgtcggtgcccac	12	10	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr15:80845010G>T	uc002bfr.2	+	10	1150	c.984G>T	c.(982-984)ATG>ATT	p.M328I	ARNT2_uc010unm.1_Missense_Mutation_p.M317I|ARNT2_uc002bfs.2_Missense_Mutation_p.M317I	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	328	PAS 2.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GCATGGACATGAATGGGATGT	0.493													T	80845010	T	T	80845010	3	4	58	1	0	0	0	0	1	0	0	0	966	1290	45	5	1022	5	ARNT2	15	80845010	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	6376566	80845010	21686382	63	3772											
C15orf26	161502	broad.mit.edu	37	chr15	81428924	81428924	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtgatgcttgtgaatcctgAtgatcctgacacagaagctg	11	8	0	6			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr15:81428924A>G	uc002bgb.2	+	3	254	c.227A>G	c.(226-228)GAT>GGT	p.D76G	C15orf26_uc010blp.1_Missense_Mutation_p.D51G	NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	76											0						GTGAATCCTGATGATCCTGAC	0.408													G	81428924	G	G	81428924	3	3	58	1	0	0	0	0	1	0	0	0	1787	333	12	4	237	4	C15orf26	15	81428924	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	583914	81428924	21102468	64	3773											
PAQR4	124222	broad.mit.edu	37	chr16	3021597	3021597	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggtgggctacactgtgttgtCgggtgtggccggctggcgtg	20	8	0	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr16:3021597C>T	uc002csj.3	+	3	804	c.470C>T	c.(469-471)TCG>TTG	p.S157L	PAQR4_uc002csk.3_Missense_Mutation_p.S118L|PAQR4_uc002csl.3_Missense_Mutation_p.S83L|PAQR4_uc010uwm.1_Missense_Mutation_p.S88L	NM_152341	NP_689554	Q8N4S7	PAQR4_HUMAN	progestin and adipoQ receptor family member IV	157	Helical; (Potential).					integral to membrane	receptor activity				0						ACTGTGTTGTCGGGTGTGGCC	0.687													T	3021597	T	T	3021597	3	4	58	1	0	0	0	0	1	0	0	0	11437	893	31	2	480	2	PAQR4	16	3021597	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08		3021597	87333156	65	3774											
MYH11	4629	broad.mit.edu	37	chr16	15841499	15841499	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgatcttcaaatctcgctccTcctctaggtgggccaggacg	10	13	4	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr16:15841499T>C	uc002ddy.2	-	19	2446	c.2339A>G	c.(2338-2340)GAG>GGG	p.E780G	MYH11_uc002ddv.2_Missense_Mutation_p.E787G|MYH11_uc002ddw.2_Missense_Mutation_p.E780G|MYH11_uc002ddx.2_Missense_Mutation_p.E787G|MYH11_uc010bvg.2_Missense_Mutation_p.E612G	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	780	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						ATCTCGCTCCTCCTCTAGGTG	0.498			T	CBFB	AML								C	15841499	C	C	15841499	3	2	58	1	0	0	0	0	1	0	0	0	10031	1551	54	4	3706	4	MYH11	16	15841499	Missense_Mutation	SNP	T	TCGA-06-0686-01A-01W-0348-08	12819902	15841499	74513254	66	3775											
RBBP6	5930	broad.mit.edu	37	chr16	24582927	24582927	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatctggacagaaaaatAaaccaagggaagagagagat	11	6	1	3			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr16:24582927A>C	uc002dmh.2	+	18	5580	c.4540A>C	c.(4540-4542)AAA>CAA	p.K1514Q	RBBP6_uc002dmi.2_Missense_Mutation_p.K1480Q|RBBP6_uc010bxr.2_Missense_Mutation_p.K674Q|RBBP6_uc002dmk.2_Missense_Mutation_p.K1347Q	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1514	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		ACAGAAAAATAAACCAAGGGA	0.368													C	24582927	C	C	24582927	3	2	58	1	0	0	0	0	1	0	0	0	13103	363	13	5	4664	5	RBBP6	16	24582927	Missense_Mutation	SNP	A	TCGA-06-0686-01A-01W-0348-08	8741428	24582927	65771826	67	3776											
RNF40	9810	broad.mit.edu	37	chr16	30774800	30774800	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccagggggagctgtcttcagCgcctgaggcacctgggaccc	15	14	2	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr16:30774800C>A	uc002dzq.2	+	4	485	c.362C>A	c.(361-363)GCG>GAG	p.A121E	C16orf93_uc002dzm.2_5'Flank|C16orf93_uc002dzn.2_5'Flank|C16orf93_uc002dzo.2_5'Flank|C16orf93_uc002dzp.2_5'Flank|RNF40_uc010caa.2_Missense_Mutation_p.A121E|RNF40_uc010cab.2_Missense_Mutation_p.A121E|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Missense_Mutation_p.A121E|RNF40_uc010vfb.1_Intron	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	121					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			CTGTCTTCAGCGCCTGAGGCA	0.562													A	30774800	A	A	30774800	3	1	58	1	0	0	0	0	1	0	0	0	13493	768	27	5	372	5	RNF40	16	30774800	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	6191873	30774800	59579953	68	3777											
ZNF23	7571	broad.mit.edu	37	chr16	71483233	71483233	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aatgggaactgtagctgaagCttttcccacactccacacat	7	12	0	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr16:71483233C>A	uc002faf.2	-	6	1509	c.695G>T	c.(694-696)AGC>ATC	p.S232I	ZNF23_uc002fad.2_Missense_Mutation_p.S174I|ZNF23_uc002fae.2_Missense_Mutation_p.S174I|ZNF23_uc010vmf.1_Missense_Mutation_p.S174I|ZNF23_uc002fag.2_Missense_Mutation_p.S174I|ZNF23_uc002fah.2_Missense_Mutation_p.S232I|ZNF23_uc002fai.2_Missense_Mutation_p.S271I	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	232	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		GTAGCTGAAGCTTTTCCCACA	0.448													A	71483233	A	A	71483233	3	1	58	1	0	0	0	0	1	0	0	0	17780	797	28	5	1240	5	ZNF23	16	71483233	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	40708433	71483233	18871520	69	3778											
SMARCD2	6603	broad.mit.edu	37	chr17	61912798	61912798	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcagttttccttccactcGgagttcccaggaagccacct	8	15	0	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr17:61912798G>A	uc010deb.1	-	5	1014	c.697C>T	c.(697-699)CGA>TGA	p.R233*	SMARCD2_uc010wpt.1_Nonsense_Mutation_p.R185*|SMARCD2_uc010dea.1_Nonsense_Mutation_p.R158*|SMARCD2_uc010dec.1_Nonsense_Mutation_p.R212*	NM_001098426	NP_001091896	Q92925	SMRD2_HUMAN	SWI/SNF-related matrix-associated	233					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity				0						CCTTCCACTCGGAGTTCCCAG	0.527													A	61912798	A	A	61912798	4	1	58	1	0	0	0	0	0	1	0	0	14778	1124	39	2	934	2	SMARCD2	17	61912798	Nonsense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08		61912798	19282412	70	3779											
ABCA8	10351	broad.mit.edu	37	chr17	66928560	66928560	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caggaaaaaaggtacaaatcAgttataactcctgattgacc	7	8	1	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr17:66928560A>T	uc002jhp.2	-	6	845	c.666T>A	c.(664-666)ACT>ACA	p.T222T	ABCA8_uc002jhq.2_Silent_p.T222T|ABCA8_uc010wqq.1_Silent_p.T222T|ABCA8_uc010wqr.1_Silent_p.T161T|ABCA8_uc002jhr.2_Silent_p.T222T|ABCA8_uc002jhs.2_Silent_p.T222T|ABCA8_uc002jht.2_Silent_p.T222T	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	222	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					GGTACAAATCAGTTATAACTC	0.363													T	66928560	T	T	66928560	2	4	58	1	0	0	0	0	0	0	0	1	38	175	7	5		5	ABCA8	17	66928560	Silent	SNP	A	TCGA-06-0686-01A-01W-0348-08	5015762	66928560	14266650	71	3780											
CD7	924	broad.mit.edu	37	chr17	80274786	80274786	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtagatcccacgcaggccccCgctggtggagcaggtgatgt	15	12	0	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr17:80274786C>A	uc002kel.1	-	2	263	c.154G>T	c.(154-156)GGG>TGG	p.G52W	CD7_uc010din.2_Missense_Mutation_p.G52W|CD7_uc002kem.2_Missense_Mutation_p.R33L|CD7_uc010wvk.1_Missense_Mutation_p.G52W	NM_006137	NP_006128	P09564	CD7_HUMAN	CD7 antigen precursor	52	Ig-like.|Extracellular (Probable).				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			CGCAGGCCCCCGCTGGTGGAG	0.647													A	80274786	A	A	80274786	3	1	58	1	0	0	0	0	1	0	0	0	3032	652	23	5	580	5	CD7	17	80274786	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	13346226	80274786	920424	72	3781											
MUC16	94025	broad.mit.edu	37	chr19	9015333	9015333	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctcacctgagcaaggtcagtCtgcagccagagtacagaggg	13	11	3	3			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr19:9015333C>T	uc002mkp.2	-	30	38459	c.38255G>A	c.(38254-38256)AGA>AAA	p.R12752K	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12754	SEA 5.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAAGGTCAGTCTGCAGCCAGA	0.517													T	9015333	T	T	9015333	3	4	58	1	0	0	0	0	1	0	0	0	9973	913	32	3	5488	3	MUC16	19	9015333	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08		9015333	50113650	73	3782											
CYP4F3	4051	broad.mit.edu	37	chr19	15758065	15758065	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgccaccgtcggatgctgacGcctgccttccatttcaacat	8	16	1	1	rs138865516		TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr19:15758065G>A	uc002nbj.2	+	5	506	c.456G>A	c.(454-456)ACG>ACA	p.T152T	CYP4F3_uc010xok.1_Silent_p.T152T|CYP4F3_uc010xol.1_Silent_p.T152T|CYP4F3_uc010xom.1_Silent_p.T3T|CYP4F3_uc002nbk.2_Silent_p.T152T|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	152					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						GGATGCTGACGCCTGCCTTCC	0.552													A	15758065	A	A	15758065	2	1	58	1	0	0	0	0	0	0	0	1	4190	1074	38	1		1	CYP4F3	19	15758065	Silent	SNP	G	TCGA-06-0686-01A-01W-0348-08	6742732	15758065	43370918	74	3783											
ZNF493	284443	broad.mit.edu	37	chr19	21606980	21606980	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatcttcaacccttagtataCataaaataattcatactgga	3	8	3	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr19:21606980C>T	uc002npx.2	+	2	1415	c.1135C>T	c.(1135-1137)CAT>TAT	p.H379Y	ZNF493_uc002npw.2_Missense_Mutation_p.H507Y|ZNF493_uc002npy.2_Missense_Mutation_p.H379Y	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	379	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCTTAGTATACATAAAATAAT	0.328													T	21606980	T	T	21606980	3	4	58	1	0	0	0	0	1	0	0	0	17941	478	17	3	1596	3	ZNF493	19	21606980	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	5848915	21606980	37522003	75	3784											
ZSCAN5A	79149	broad.mit.edu	37	chr19	56733609	56733609	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaagcttctctctccacaaCgcaggcagaaggtgtgtcag	11	12	3	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr19:56733609C>T	uc002qmq.2	-	5	992	c.826G>A	c.(826-828)GTT>ATT	p.V276I	ZSCAN5A_uc010ygi.1_Missense_Mutation_p.V159I|ZSCAN5A_uc002qmr.2_Missense_Mutation_p.V276I|ZSCAN5A_uc002qms.1_Missense_Mutation_p.V275I	NM_024303	NP_077279	Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	276					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CTCTCCACAACGCAGGCAGAA	0.527													T	56733609	T	T	56733609	3	4	58	1	0	0	0	0	1	0	0	0	18235	536	19	1	668	1	ZSCAN5A	19	56733609	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	35126629	56733609	2395374	76	3785											
GRIK1	2897	broad.mit.edu	37	chr21	31023612	31023612	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatccaaagcaaataagtcCtgcatagtatcaaaaaggat	7	7	1	1			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr21:31023612C>T	uc002yno.1	-	6	1245	c.781_splice	c.e6-1	p.D261_splice	GRIK1_uc002ynn.2_Splice_Site_p.D261_splice|GRIK1_uc011acs.1_Splice_Site_p.D261_splice|GRIK1_uc011act.1_Splice_Site_p.D205_splice|GRIK1_uc010glq.1_Splice_Site_p.D119_splice|GRIK1_uc002ynr.2_Splice_Site_p.D261_splice	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1						central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CAAATAAGTCCTGCATAGTAT	0.348													T	31023612	T	T	31023612	5	4	58	1	0	0	0	0	0	0	1	0	6773	695	24	3	2184	3	GRIK1	21	31023612	Splice_Site	SNP	C	TCGA-06-0686-01A-01W-0348-08		31023612	17106283	77	3786											
CBS	875	broad.mit.edu	37	chr21	44478273	44478273	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acctgtttgaactgcttgtaGatgactttgccaacttggtc	9	9	0	3			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chr21:44478273G>C	uc002zcu.2	-	15	1694	c.1449C>G	c.(1447-1449)ATC>ATG	p.I483M	CBS_uc002zcs.1_Missense_Mutation_p.I378M|CBS_uc002zct.2_Missense_Mutation_p.I483M|CBS_uc002zcw.3_Missense_Mutation_p.I483M|CBS_uc002zcv.2_Missense_Mutation_p.I483M|CBS_uc002zcx.2_Missense_Mutation_p.I102M	NM_000071	NP_000062	P35520	CBS_HUMAN	cystathionine-beta-synthase	483					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	ACTGCTTGTAGATGACTTTGC	0.567													C	44478273	C	C	44478273	3	2	58	1	0	0	0	0	1	0	0	0	2711	932	33	5	218	5	CBS	21	44478273	Missense_Mutation	SNP	G	TCGA-06-0686-01A-01W-0348-08	13454661	44478273	3651622	78	3787											
BMP15	9210	broad.mit.edu	37	chrX	50659431	50659431	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tacgcgatggtctcaattccCccaatcacgccattattcag	6	14	3	0			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chrX:50659431C>A	uc011mnw.1	+	2	1003	c.1003C>A	c.(1003-1005)CCC>ACC	p.P335T		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	335					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					TCTCAATTCCCCCAATCACGC	0.502													A	50659431	A	A	50659431	3	1	58	1	0	0	0	0	1	0	0	0	1458	623	22	5	1009	5	BMP15	23	50659431	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08		50659431	104611129	79	3788											
BCORL1	63035	broad.mit.edu	37	chrX	129162640	129162640	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccgtaagcagaagacttcctCctcccaaagtttggagcacc	8	14	0	2			TCGA-06-0686-01A-01W-0348-08	TCGA-06-0686-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	4af220fa-c00b-40b1-ae82-b2c256a3d3fe	ef3a66de-f4db-4ef4-8737-bbd7ae26cb67	g.chrX:129162640C>T	uc004evb.1	+	8	4223	c.4109C>T	c.(4108-4110)TCC>TTC	p.S1370F	BCORL1_uc010nrd.1_Missense_Mutation_p.S1142F|BCORL1_uc004evc.1_Missense_Mutation_p.S132F	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1370					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						AAGACTTCCTCCTCCCAAAGT	0.483											OREG0019921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	129162640	T	T	129162640	3	4	58	1	0	0	0	0	1	0	0	0	1387	855	30	3	4135	3	BCORL1	23	129162640	Missense_Mutation	SNP	C	TCGA-06-0686-01A-01W-0348-08	78503209	129162640	26107920	80	3789											
ARHGEF16	27237	broad.mit.edu	37	chr1	3389688	3389688	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acaaggcccaggtgctggtcGaggacatcagtgacatcctg	13	11	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:3389688G>A	uc001akg.3	+	7	1317	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	ARHGEF16_uc001aki.2_Missense_Mutation_p.E69K|ARHGEF16_uc001akj.2_Missense_Mutation_p.E69K|ARHGEF16_uc009vli.1_Missense_Mutation_p.E61K|ARHGEF16_uc010nzh.1_Missense_Mutation_p.E61K	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	357	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GGTGCTGGTCGAGGACATCAG	0.632													A	3389688	A	A	3389688	3	1	59	1	0	0	0	0	1	0	0	0	899	1059	37	2	1091	2	ARHGEF16	1	3389688	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08		3389688	245860933	1	3790											
MAST2	23139	broad.mit.edu	37	chr1	46500629	46500629	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacttctcgcaagcacagcCttgacctgccccactctgaa	6	18	2	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:46500629C>T	uc001cov.2	+	29	4571	c.4288C>T	c.(4288-4290)CTT>TTT	p.L1430F	MAST2_uc001cow.2_Missense_Mutation_p.L1429F|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	1430					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CAAGCACAGCCTTGACCTGCC	0.592													T	46500629	T	T	46500629	3	4	59	1	0	0	0	0	1	0	0	0	9325	681	24	3	4402	3	MAST2	1	46500629	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	43110941	46500629	202749992	2	3791											
CC2D1B	200014	broad.mit.edu	37	chr1	52820329	52820329	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctccagccgctccagtttcAggtgtgctgtgccaaccagc	10	15	2	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:52820329A>G	uc001ctq.1	-	23	2537	c.2399T>C	c.(2398-2400)CTG>CCG	p.L800P	CC2D1B_uc001ctr.2_Missense_Mutation_p.L340P|CC2D1B_uc001cts.2_Missense_Mutation_p.L485P	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	800										ovary(2)	2						CTCCAGTTTCAGGTGTGCTGT	0.567													G	52820329	G	G	52820329	3	3	59	1	0	0	0	0	1	0	0	0	2727	188	7	4	185	4	CC2D1B	1	52820329	Missense_Mutation	SNP	A	TCGA-06-0743-01A-01D-1492-08	6319700	52820329	196430292	3	3792											
PIAS3	10401	broad.mit.edu	37	chr1	145584562	145584562	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtggggatttcctgtccaGtctcccactacatgagtacc	11	12	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:145584562G>A	uc001eoc.1	+	12	1620	c.1529G>A	c.(1528-1530)AGT>AAT	p.S510N	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Missense_Mutation_p.S179N	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	510					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCCTGTCCAGTCTCCCACTA	0.592													A	145584562	A	A	145584562	3	1	59	1	0	0	0	0	1	0	0	0	11877	1029	36	3	1575	3	PIAS3	1	145584562	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	92764233	145584562	103666059	4	3793											
FLG	2312	broad.mit.edu	37	chr1	152286200	152286200	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctgtctgctgactgctggtGgccggatccatgtctttctc	12	12	3	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:152286200G>T	uc001ezu.1	-	3	1198	c.1162C>A	c.(1162-1164)CAC>AAC	p.H388N	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	388	Ser-rich.|Filaggrin 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTGCTGGTGGCCGGATCCA	0.577									Ichthyosis				T	152286200	T	T	152286200	3	4	59	1	0	0	0	0	1	0	0	0	5922	1348	47	5	11027	5	FLG	1	152286200	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	6701638	152286200	96964421	5	3794											
FLG2	388698	broad.mit.edu	37	chr1	152323312	152323312	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tactagatctggaacctgtcTgtgtggattgtccataacca	9	9	2	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:152323312T>G	uc001ezw.3	-	3	7023	c.6950A>C	c.(6949-6951)CAG>CCG	p.Q2317P	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2317							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAACCTGTCTGTGTGGATTG	0.463													G	152323312	G	G	152323312	3	3	59	1	0	0	0	0	1	0	0	0	5923	1580	55	5	229	5	FLG2	1	152323312	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	37112	152323312	96927309	6	3795											
LCE3E	353145	broad.mit.edu	37	chr1	152538509	152538509	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcgccggcatcggtggtggCgcctgtggtggttcaggaag	20	9	1	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:152538509C>T	uc001faa.2	-	2	232	c.176G>A	c.(175-177)CGC>CAC	p.R59H		NM_178435	NP_848522	Q5T5B0	LCE3E_HUMAN	late cornified envelope 3E	59					keratinization					ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		Lung(1;0.000294)|LUAD - Lung adenocarcinoma(1;0.00527)|LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)		TCGGTGGTGGCGCCTGTGGTG	0.682													T	152538509	T	T	152538509	3	4	59	1	0	0	0	0	1	0	0	0	8673	768	27	1	106	1	LCE3E	1	152538509	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	215197	152538509	96712112	7	3796											
CD5L	922	broad.mit.edu	37	chr1	157805716	157805716	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtatcttctgttcctgtgcaActgactgattggatgaggac	11	8	2	3			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:157805716A>G	uc001frk.3	-	3	428	c.285T>C	c.(283-285)AGT>AGC	p.S95S		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	95	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTCCTGTGCAACTGACTGATT	0.493													G	157805716	G	G	157805716	2	3	59	1	0	0	0	0	0	0	0	1	3027	40	2	4		4	CD5L	1	157805716	Silent	SNP	A	TCGA-06-0743-01A-01D-1492-08	5267207	157805716	91444905	8	3797											
ZNF124	7678	broad.mit.edu	37	chr1	247320190	247320190	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccttgcaaggaactgagaCaactgaaagctttgccacat	9	10	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:247320190C>T	uc001ick.2	-	4	873	c.734G>A	c.(733-735)TGT>TAT	p.C245Y	ZNF124_uc001ici.2_Intron|ZNF124_uc001icj.1_Missense_Mutation_p.C183Y	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	245	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			GGAACTGAGACAACTGAAAGC	0.458													T	247320190	T	T	247320190	3	4	59	1	0	0	0	0	1	0	0	0	17717	478	17	3	325	3	ZNF124	1	247320190	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	89514474	247320190	1930431	9	3798											
PGBD2	267002	broad.mit.edu	37	chr1	249212440	249212440	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcttcgatatgattgggcacTggattatccatcaggacaag	11	8	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr1:249212440T>A	uc001ifh.2	+	3	1804	c.1657T>A	c.(1657-1659)TGG>AGG	p.W553R	PGBD2_uc001ifg.2_Missense_Mutation_p.W302R|PGBD2_uc009xhd.2_Missense_Mutation_p.W550R	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	553										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GATTGGGCACTGGATTATCCA	0.547													A	249212440	A	A	249212440	3	1	59	1	0	0	0	0	1	0	0	0	11781	1580	55	5	1663	5	PGBD2	1	249212440	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	1892250	249212440	38181	10	3799											
IL1F8	27177	broad.mit.edu	37	chr2	113780342	113780342	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgttgaaaggaactcttcCacttctttctacctgcagga	8	10	3	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr2:113780342C>T	uc002tiq.1	-	6	508	c.404G>A	c.(403-405)TGG>TAG	p.W135*		NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	135					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						GGAACTCTTCCACTTCTTTCT	0.438													T	113780342	T	T	113780342	4	4	59	1	0	0	0	0	0	1	0	0	7656	595	21	3	94	3	IL1F8	2	113780342	Nonsense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08		113780342	129419031	11	3800											
GALNT5	11227	broad.mit.edu	37	chr2	158165160	158165160	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatccctgataaaggagccGtaaggctgcacccttgtgat	10	12	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr2:158165160G>A	uc002tzg.2	+	9	2857	c.2602G>A	c.(2602-2604)GTA>ATA	p.V868I	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	868	Lumenal (Potential).|Ricin B-type lectin.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						TAAAGGAGCCGTAAGGCTGCA	0.408													A	158165160	A	A	158165160	3	1	59	1	0	0	0	0	1	0	0	0	6216	1145	40	1	2636	1	GALNT5	2	158165160	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	44384818	158165160	85034213	12	3801											
TTN	7273	broad.mit.edu	37	chr2	179553840	179553840	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaactttctcctctgggaCgggtttcttaggcagagctg	12	10	3	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr2:179553840C>T	uc010zfg.1	-	122	28527	c.28303G>A	c.(28303-28305)GTC>ATC	p.V9435I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V6096I|TTN_uc010fre.1_Missense_Mutation_p.V546I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10362							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTCTGGGACGGGTTTCTTA	0.428													T	179553840	T	T	179553840	3	4	59	1	0	0	0	0	1	0	0	0	16732	536	19	1	72446	1	TTN	2	179553840	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	21388680	179553840	63645533	13	3802											
CCDC108	255101	broad.mit.edu	37	chr2	219892442	219892442	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggcggctggaagtgcaggCgcatggccatggacttgagt	18	8	0	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr2:219892442C>T	uc002vjl.1	-	13	2225	c.2141G>A	c.(2140-2142)CGC>CAC	p.R714H	CCDC108_uc010fwa.1_Missense_Mutation_p.R157H|CCDC108_uc010zkp.1_Missense_Mutation_p.R703H|CCDC108_uc010zkq.1_Missense_Mutation_p.R649H	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	714						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAAGTGCAGGCGCATGGCCAT	0.597													T	219892442	T	T	219892442	3	4	59	1	0	0	0	0	1	0	0	0	2743	768	27	1	3728	1	CCDC108	2	219892442	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	40338602	219892442	23306931	14	3803											
COL6A3	1293	broad.mit.edu	37	chr2	238289831	238289831	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccctcggcagcccggtagcCggctgaactcgtgaataggt	13	14	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr2:238289831C>T	uc002vwl.2	-	5	1909	c.1624G>A	c.(1624-1626)GGC>AGC	p.G542S	COL6A3_uc002vwo.2_Missense_Mutation_p.G336S|COL6A3_uc010znj.1_Missense_Mutation_p.G135S|COL6A3_uc002vwq.2_Missense_Mutation_p.G336S|COL6A3_uc002vwr.2_Missense_Mutation_p.G135S|COL6A3_uc010znk.1_Missense_Mutation_p.G542S	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	542	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCCCGGTAGCCGGCTGAACTC	0.557													T	238289831	T	T	238289831	3	4	59	1	0	0	0	0	1	0	0	0	3701	652	23	2	8116	2	COL6A3	2	238289831	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	18397389	238289831	4909542	15	3804											
PER2	8864	broad.mit.edu	37	chr2	239161798	239161798	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaagcacatggctgtctggGgatcgaggtccggctgggga	17	9	1	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr2:239161798G>A	uc002vyc.2	-	19	3103	c.2866C>T	c.(2866-2868)CCC>TCC	p.P956S	PER2_uc010znv.1_Missense_Mutation_p.P956S	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	956	Pro-rich.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		GGCTGTCTGGGGATCGAGGTC	0.667													A	239161798	A	A	239161798	3	1	59	1	0	0	0	0	1	0	0	0	11730	1232	43	3	921	3	PER2	2	239161798	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	871967	239161798	4037575	16	3805											
AQP12A	375318	broad.mit.edu	37	chr2	241631371	241631371	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctctccttcttctttgccaCcttcgccctctgtgaggcgg	8	17	4	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr2:241631371C>T	uc002vzu.2	+	1	110	c.41C>T	c.(40-42)ACC>ATC	p.T14I	AQP12A_uc002vzv.2_Intron	NM_198998	NP_945349	Q8IXF9	AQ12A_HUMAN	aquaporin 12A	14	Helical; Name=1; (Potential).					integral to membrane	transporter activity				0		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		TTCTTTGCCACCTTCGCCCTC	0.677													T	241631371	T	T	241631371	3	4	59	1	0	0	0	0	1	0	0	0	824	507	18	3	43	3	AQP12A	2	241631371	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	2469573	241631371	1568002	17	3806											
PLCD1	5333	broad.mit.edu	37	chr3	38050824	38050824	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gacgccatctcgtagaaggcCtgtccaggggtgccaggact	14	12	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr3:38050824C>A	uc003chn.2	-	10	1669	c.1545G>T	c.(1543-1545)CAG>CAT	p.Q515H	PLCD1_uc003chm.2_Missense_Mutation_p.Q536H	NM_006225	NP_006216	P51178	PLCD1_HUMAN	phospholipase C, delta 1 isoform 2	515	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CGTAGAAGGCCTGTCCAGGGG	0.577													A	38050824	A	A	38050824	3	1	59	1	0	0	0	0	1	0	0	0	12031	680	24	5	749	5	PLCD1	3	38050824	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08		38050824	159971606	18	3807											
SCN10A	6336	broad.mit.edu	37	chr3	38783979	38783979	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagatacttctgagacaagcTggtcaagcagggtgggcact	13	9	2	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr3:38783979T>A	uc003ciq.2	-	13	1909	c.1909A>T	c.(1909-1911)AGC>TGC	p.S637C		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	637					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGAGACAAGCTGGTCAAGCAG	0.468													A	38783979	A	A	38783979	3	1	59	1	0	0	0	0	1	0	0	0	13912	1580	55	5	4021	5	SCN10A	3	38783979	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	733155	38783979	159238451	19	3808											
ITIH3	3699	broad.mit.edu	37	chr3	52842629	52842629	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaaggttgtctgctggttcGtccacaacaacggagaaggg	14	9	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr3:52842629G>A	uc003dfv.2	+	22	2641	c.2605G>A	c.(2605-2607)GTC>ATC	p.V869I	ITIH3_uc011bek.1_Missense_Mutation_p.V677I	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	869					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CTGCTGGTTCGTCCACAACAA	0.537													A	52842629	A	A	52842629	3	1	59	1	0	0	0	0	1	0	0	0	7905	1145	40	1	2691	1	ITIH3	3	52842629	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	14058650	52842629	145179801	20	3809											
ALG1L	200810	broad.mit.edu	37	chr3	125651539	125651539	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggttgtgtccatcaagagtAagttgttcaaactctgtgtt	10	6	3	1	rs147593769	by1000genomes	TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr3:125651539A>C	uc003eig.1	-	3	278	c.114T>G	c.(112-114)CTT>CTG	p.L38L		NM_001015050	NP_001015050	Q6GMV1	ALG1L_HUMAN	asparagine-linked glycosylation 1-like	38							transferase activity, transferring glycosyl groups				0						CATCAAGAGTAAGTTGTTCAA	0.353													C	125651539	C	C	125651539	2	2	59	1	0	0	0	0	0	0	0	1	517	349	13	5		5	ALG1L	3	125651539	Silent	SNP	A	TCGA-06-0743-01A-01D-1492-08	72808910	125651539	72370891	21	3810											
NAALADL2	254827	broad.mit.edu	37	chr3	174951943	174951943	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaagccagaaaagatagcagCcaagacctgctctattcata	8	10	2	3			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr3:174951943C>G	uc003fit.2	+	3	855	c.768C>G	c.(766-768)AGC>AGG	p.S256R	NAALADL2_uc003fiu.1_Missense_Mutation_p.S249R|NAALADL2_uc010hwy.1_Missense_Mutation_p.S78R	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	256	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		AAGATAGCAGCCAAGACCTGC	0.463													G	174951943	G	G	174951943	3	3	59	1	0	0	0	0	1	0	0	0	10130	738	26	5	778	5	NAALADL2	3	174951943	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	49300404	174951943	23070487	22	3811											
YEATS2	55689	broad.mit.edu	37	chr3	183470006	183470006	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttcttcaccaataaagcagtCacatgagccagtacccgata	6	12	3	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr3:183470006C>T	uc003fly.2	+	10	1310	c.1115C>T	c.(1114-1116)TCA>TTA	p.S372L		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	372					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATAAAGCAGTCACATGAGCCA	0.478													T	183470006	T	T	183470006	3	4	59	1	0	0	0	0	1	0	0	0	17469	838	29	3	1149	3	YEATS2	3	183470006	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	8518063	183470006	14552424	23	3812											
VPS8	23355	broad.mit.edu	37	chr3	184714255	184714255	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgcagcagtacaagagaCgccaagaaatggctgatgaa	12	7	0	4			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr3:184714255C>T	uc003fpb.1	+	43	3967	c.3796C>T	c.(3796-3798)CGC>TGC	p.R1266C	VPS8_uc010hyd.1_Missense_Mutation_p.R1176C|VPS8_uc010hye.1_Missense_Mutation_p.R695C	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1268	RING-type; atypical.						zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GTACAAGAGACGCCAAGAAAT	0.413													T	184714255	T	T	184714255	3	4	59	1	0	0	0	0	1	0	0	0	17215	536	19	1	3968	1	VPS8	3	184714255	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	1244249	184714255	13308175	24	3813											
DGKQ	1609	broad.mit.edu	37	chr4	956607	956607	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaggctccgggcaggccagtCggtaccgtgtctcctccagg	14	14	1	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr4:956607C>T	uc003gbw.2	-	17	2062	c.1988G>A	c.(1987-1989)CGA>CAA	p.R663Q	DGKQ_uc010ibn.2_Missense_Mutation_p.R650Q	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	663	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GCAGGCCAGTCGGTACCGTGT	0.687													T	956607	T	T	956607	3	4	59	1	0	0	0	0	1	0	0	0	4473	884	31	2	868	2	DGKQ	4	956607	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08		956607	190197669	25	3814											
KLHL5	51088	broad.mit.edu	37	chr4	39116882	39116882	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ataagttatatgctgttgggGggtatgatggacaggcatac	14	4	0	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr4:39116882G>A	uc003gts.2	+	10	2218	c.2143G>A	c.(2143-2145)GGG>AGG	p.G715R	KLHL5_uc003gtp.2_Missense_Mutation_p.G669R|KLHL5_uc003gtq.2_Missense_Mutation_p.G528R|KLHL5_uc003gtr.1_Missense_Mutation_p.G715R|KLHL5_uc003gtt.2_Missense_Mutation_p.G654R	NM_015990	NP_057074	Q96PQ7	KLHL5_HUMAN	kelch-like 5 isoform 1	715	Kelch 6.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1						TGCTGTTGGGGGGTATGATGG	0.458													A	39116882	A	A	39116882	3	1	59	1	0	0	0	0	1	0	0	0	8392	1232	43	3	2181	3	KLHL5	4	39116882	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	38160275	39116882	152037394	26	3815											
IGJ	3512	broad.mit.edu	37	chr4	71527860	71527860	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattaggatcttcggaagaaCggatgatcctggaagtaatc	11	7	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr4:71527860C>T	uc003hfn.3	-	2	278	c.137G>A	c.(136-138)CGT>CAT	p.R46H	IGJ_uc010ihz.2_Missense_Mutation_p.R62H	NM_144646	NP_653247	P01591	IGJ_HUMAN	immunoglobulin J chain	46					immune response	extracellular region	antigen binding				0			Lung(101;0.235)			TTCGGAAGAACGGATGATCCT	0.383													T	71527860	T	T	71527860	3	4	59	1	0	0	0	0	1	0	0	0	7592	536	19	1	354	1	IGJ	4	71527860	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	32410978	71527860	119626416	27	3816											
CXXC4	80319	broad.mit.edu	37	chr4	105412449	105412449	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggagtcgtttcggtggtGcatgctggtcctgctgccgc	16	11	0	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr4:105412449G>A	uc003hxg.2	-	1	19	c.4C>T	c.(4-6)CAC>TAC	p.H2Y	uc003hxh.1_Intron|CXXC4_uc010ilo.2_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	CXXC finger 4	2					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TTTCGGTGGTGCATGCTGGTC	0.378													A	105412449	A	A	105412449	3	1	59	1	0	0	0	0	1	0	0	0	4098	1319	46	3	600	3	CXXC4	4	105412449	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	33884589	105412449	85741827	28	3817											
CDH18	1016	broad.mit.edu	37	chr5	19747216	19747216	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aagcacatagtgggtcttctGctctctgtctaggctttttg	10	9	4	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr5:19747216G>T	uc003jgc.2	-	3	735	c.358C>A	c.(358-360)CAG>AAG	p.Q120K	CDH18_uc003jgd.2_Missense_Mutation_p.Q120K|CDH18_uc011cnm.1_Missense_Mutation_p.Q120K	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	120	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TGGGTCTTCTGCTCTCTGTCT	0.433													T	19747216	T	T	19747216	3	4	59	1	0	0	0	0	1	0	0	0	3103	1328	46	5	2054	5	CDH18	5	19747216	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08		19747216	161168044	29	3818											
PRDM9	56979	broad.mit.edu	37	chr5	23523414	23523414	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actcagatcaccaaggggagAaactgctatgagtatgtgga	12	7	2	3			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr5:23523414A>G	uc003jgo.2	+	9	1079	c.897A>G	c.(895-897)AGA>AGG	p.R299R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	299	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CCAAGGGGAGAAACTGCTATG	0.428										HNSCC(3;0.000094)			G	23523414	G	G	23523414	2	3	59	1	0	0	0	0	0	0	0	1	12463	243	9	4		4	PRDM9	5	23523414	Silent	SNP	A	TCGA-06-0743-01A-01D-1492-08	3776198	23523414	157391846	30	3819											
ADAMTS12	81792	broad.mit.edu	37	chr5	33615934	33615934	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccctcctttctgcattaccTggatccacacagactcattg	5	15	2	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr5:33615934T>C	uc003jia.1	-	15	2550	c.2387A>G	c.(2386-2388)CAG>CGG	p.Q796R	ADAMTS12_uc010iuq.1_Missense_Mutation_p.Q711R	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	796	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CTGCATTACCTGGATCCACAC	0.473										HNSCC(64;0.19)			C	33615934	C	C	33615934	3	2	59	1	0	0	0	0	1	0	0	0	257	1594	55	4	2437	4	ADAMTS12	5	33615934	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	10092520	33615934	147299326	31	3820											
MAP3K1	4214	broad.mit.edu	37	chr5	56168509	56168509	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atagagaacctttaatatgtCccctttgtagatctaagtgg	8	7	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr5:56168509C>T	uc003jqw.3	+	8	1966	c.1465C>T	c.(1465-1467)CCC>TCC	p.P489S		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	489	RING-type.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		TTTAATATGTCCCCTTTGTAG	0.279													T	56168509	T	T	56168509	3	4	59	1	0	0	0	0	1	0	0	0	9243	855	30	3	1495	3	MAP3K1	5	56168509	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	22552575	56168509	124746751	32	3821											
NAIP	4671	broad.mit.edu	37	chr5	70308329	70308329	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agattcttcacccttatgtcGtacttggcaatgttaccaac	6	11	2	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr5:70308329G>A	uc003kar.1	-	4	1132	c.414C>T	c.(412-414)TAC>TAT	p.Y138Y	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Silent_p.Y138Y|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	138					anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding	p.Y138Y(1)		central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CCCTTATGTCGTACTTGGCAA	0.483													A	70308329	A	A	70308329	2	1	59	1	0	0	0	0	0	0	0	1	10147	1140	40	1		1	NAIP	5	70308329	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08	14139820	70308329	110606931	33	3822											
FAM81B	153643	broad.mit.edu	37	chr5	94749771	94749771	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccttccgcatcaaggaggaCatctctgcttgcctgcaggg	12	13	2	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr5:94749771C>T	uc003kla.1	+	4	460	c.414C>T	c.(412-414)GAC>GAT	p.D138D	FAM81B_uc010jbe.1_5'UTR	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	138										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		TCAAGGAGGACATCTCTGCTT	0.522													T	94749771	T	T	94749771	2	4	59	1	0	0	0	0	0	0	0	1	5629	477	17	3		3	FAM81B	5	94749771	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	24441442	94749771	86165489	34	3823											
PCDHA7	56141	broad.mit.edu	37	chr5	140215715	140215715	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtgagagagcttgtgccgCggtctgtgggcgcgggccat	18	10	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr5:140215715C>T	uc003lhq.2	+	1	1747	c.1747C>T	c.(1747-1749)CGG>TGG	p.R583W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.R583W	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	583	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTGTGCCGCGGTCTGTGGG	0.657													T	140215715	T	T	140215715	3	4	59	1	0	0	0	0	1	0	0	0	11529	759	27	1	1749	1	PCDHA7	5	140215715	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	45465944	140215715	40699545	35	3824											
NMUR2	56923	broad.mit.edu	37	chr5	151784353	151784353	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacaagaaagggtagttgcGccacatctcatagacctcca	9	11	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr5:151784353G>A	uc003luv.2	-	1	488	c.322C>T	c.(322-324)CGC>TGC	p.R108C		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	108	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GGGTAGTTGCGCCACATCTCA	0.587													A	151784353	A	A	151784353	3	1	59	1	0	0	0	0	1	0	0	0	10507	1087	38	1	941	1	NMUR2	5	151784353	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	11568638	151784353	29130907	36	3825											
TIMD4	91937	broad.mit.edu	37	chr5	156349123	156349123	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttacctctcaggagaaaCgccacaaacaatgcgaagag	8	12	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr5:156349123C>T	uc003lwh.2	-	7	1056	c.999G>A	c.(997-999)GCG>GCA	p.A333A	TIMD4_uc010jii.2_Silent_p.A305A|TIMD4_uc003lwg.2_Silent_p.A35A	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	333	Helical; (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCAGGAGAAACGCCACAAACA	0.517													T	156349123	T	T	156349123	2	4	59	1	0	0	0	0	0	0	0	1	15900	523	19	1		1	TIMD4	5	156349123	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	4564770	156349123	24566137	37	3826											
MYLIP	29116	broad.mit.edu	37	chr6	16143302	16143302	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accagccaggcttcagctgaAtaccaagttttgcagattgt	9	10	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr6:16143302A>C	uc003nbq.2	+	4	753	c.516A>C	c.(514-516)GAA>GAC	p.E172D	MYLIP_uc003nbr.2_5'UTR	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	172	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			CTTCAGCTGAATACCAAGTTT	0.463													C	16143302	C	C	16143302	3	2	59	1	0	0	0	0	1	0	0	0	10055	98	4	5	530	5	MYLIP	6	16143302	Missense_Mutation	SNP	A	TCGA-06-0743-01A-01D-1492-08		16143302	154971765	38	3827											
FKSG83	83954	broad.mit.edu	37	chr6	27293586	27293586	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctttctattgcatcaaagAaatcctgataaaaattattt	4	6	2	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr6:27293586A>G	uc010jqt.2	+	1	1009	c.525A>G	c.(523-525)AGA>AGG	p.R175R	FKSG83_uc010jqs.1_3'UTR	NM_032030	NP_114419	Q3KNW7	Q3KNW7_HUMAN	FKSG83	175						integral to membrane	pheromone receptor activity				0						TGCATCAAAGAAATCCTGATA	0.244													G	27293586	G	G	27293586	2	3	59	1	0	0	0	0	0	0	0	1	5918	243	9	4		4	FKSG83	6	27293586	Silent	SNP	A	TCGA-06-0743-01A-01D-1492-08	11150284	27293586	143821481	39	3828											
SLC22A7	10864	broad.mit.edu	37	chr6	43267438	43267438	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctggcatctgcagcctccGtcagctatgtaatgtttgcc	10	13	2	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr6:43267438G>A	uc003out.2	+	4	676	c.577G>A	c.(577-579)GTC>ATC	p.V193I	SLC22A7_uc010jyl.1_Missense_Mutation_p.V191I|SLC22A7_uc003ous.2_Missense_Mutation_p.V191I	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	193	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			TGCAGCCTCCGTCAGCTATGT	0.587													A	43267438	A	A	43267438	3	1	59	1	0	0	0	0	1	0	0	0	14459	1145	40	1	587	1	SLC22A7	6	43267438	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	15973852	43267438	127847629	40	3829											
AARS2	57505	broad.mit.edu	37	chr6	44270876	44270876	+	Frame_Shift_Del	DEL	C	-	-													caatgcatgggccacgggcaCccccactgataccacccgca							TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr6:44270876delC	uc010jza.1	-	16	2185	c.2182delG	c.(2182-2184)GTGfs	p.V728fs	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	728					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			ovary(1)	1	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	GCCACGGGCACCCCCACTGAT	0.602													-	44270876	-	-	44270876	7	5	59	1	0	1	0	1	0	0	0	0	20	507	18	0	803	0	AARS2	6	44270876	Frame_Shift_Del	DEL	C	TCGA-06-0743-01A-01D-1492-08	1003438	44270876	126844191	41	3830											
MEP1A	4224	broad.mit.edu	37	chr6	46806843	46806843	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcttgaccttctccatcatCgccatcctttcccaaaggcc	4	17	3	1	rs139598232	byFrequency	TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr6:46806843C>T	uc010jzh.1	+	14	2253	c.2211C>T	c.(2209-2211)ATC>ATT	p.I737I	MEP1A_uc011dwg.1_Silent_p.I459I|MEP1A_uc011dwh.1_Silent_p.I765I|MEP1A_uc011dwi.1_Silent_p.I637I	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	737	Helical; (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			TCTCCATCATCGCCATCCTTT	0.602													T	46806843	T	T	46806843	2	4	59	1	0	0	0	0	0	0	0	1	9475	874	31	2		2	MEP1A	6	46806843	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	2535967	46806843	124308224	42	3831											
C6orf221	154288	broad.mit.edu	37	chr6	74073290	74073290	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcttccaggctcaggaaagGccctcgcccaggatgtcgcc	11	15	2	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr6:74073290G>A	uc003pgt.3	+	3	414	c.361G>A	c.(361-363)GCC>ACC	p.A121T		NM_001017361	NP_001017361	Q587J8	ECAT1_HUMAN	hypothetical protein LOC154288	121										skin(2)	2						CTCAGGAAAGGCCCTCGCCCA	0.617													A	74073290	A	A	74073290	3	1	59	1	0	0	0	0	1	0	0	0	2355	1203	42	3	371	3	C6orf221	6	74073290	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	27266447	74073290	97041777	43	3832											
MACC1	346389	broad.mit.edu	37	chr7	20198221	20198221	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcactttggactgaccaataGcttttaccttaccttccccg	5	14	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr7:20198221G>A	uc003sus.3	-	5	2072	c.1763C>T	c.(1762-1764)GCT>GTT	p.A588V	MACC1_uc010kug.2_Missense_Mutation_p.A588V	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	588	SH3.				positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						CTGACCAATAGCTTTTACCTT	0.418													A	20198221	A	A	20198221	3	1	59	1	0	0	0	0	1	0	0	0	9143	971	34	3	807	3	MACC1	7	20198221	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08		20198221	138940442	44	3833											
EGFR	1956	broad.mit.edu	37	chr7	55214352	55214352	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	accctgccctgtgcaacgtgGagagcatccagtggcgggac	14	13	0	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr7:55214352G>A	uc003tqk.2	+	4	724	c.478G>A	c.(478-480)GAG>AAG	p.E160K	EGFR_uc003tqh.2_Missense_Mutation_p.E160K|EGFR_uc003tqi.2_Missense_Mutation_p.E160K|EGFR_uc003tqj.2_Missense_Mutation_p.E160K|EGFR_uc010kzg.1_Intron|EGFR_uc011kco.1_Missense_Mutation_p.E107K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	160	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGCAACGTGGAGAGCATCCA	0.552		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55214352	A	A	55214352	3	1	59	1	0	0	0	0	1	0	0	0	4967	1175	41	3	492	3	EGFR	7	55214352	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	35016131	55214352	103924311	45	3834											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	59	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	7470	55221822	103916841	46	3835											
COL1A2	1278	broad.mit.edu	37	chr7	94056341	94056341	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtcaccatggtgatcaaggtGctcctggctccgtgggtcct	13	12	2	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr7:94056341G>C	uc003ung.1	+	47	3598	c.3127G>C	c.(3127-3129)GCT>CCT	p.A1043P	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1043					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGATCAAGGTGCTCCTGGCTC	0.458										HNSCC(75;0.22)			C	94056341	C	C	94056341	3	2	59	1	0	0	0	0	1	0	0	0	3678	1319	46	5	3313	5	COL1A2	7	94056341	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	38834519	94056341	65082322	47	3836											
NPTX2	4885	broad.mit.edu	37	chr7	98254262	98254262	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctttaagtcaccagatgcGttcaaggtgtccctcccact	8	14	2	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr7:98254262G>A	uc003upl.2	+	3	849	c.672G>A	c.(670-672)GCG>GCA	p.A224A		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	224					synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			CACCAGATGCGTTCAAGGTGT	0.602													A	98254262	A	A	98254262	2	1	59	1	0	0	0	0	0	0	0	1	10603	1132	40	1		1	NPTX2	7	98254262	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08	4197921	98254262	60884401	48	3837											
TRRAP	8295	broad.mit.edu	37	chr7	98528341	98528341	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtggtatgcaaagctgggggGtgtggtgtctattaagtttc	16	4	1	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr7:98528341G>T	uc003upp.2	+	25	3688	c.3479G>T	c.(3478-3480)GGT>GTT	p.G1160V	TRRAP_uc011kis.1_Missense_Mutation_p.G1160V|TRRAP_uc003upr.2_Missense_Mutation_p.G852V	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1160					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAGCTGGGGGGTGTGGTGTCT	0.517													T	98528341	T	T	98528341	3	4	59	1	0	0	0	0	1	0	0	0	16598	1261	44	5	3573	5	TRRAP	7	98528341	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	274079	98528341	60610322	49	3838											
IFRD1	3475	broad.mit.edu	37	chr7	112112859	112112859	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgtatttgaacttggaccCccagtgatgcttgatgctgc	10	9	0	3			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr7:112112859C>T	uc003vgh.2	+	12	1652	c.1209C>T	c.(1207-1209)CCC>CCT	p.P403P	IFRD1_uc011kmn.1_Silent_p.P353P|IFRD1_uc003vgj.2_Silent_p.P403P|IFRD1_uc011kmo.1_RNA|IFRD1_uc011kmp.1_Silent_p.P353P|IFRD1_uc003vgk.2_Silent_p.P120P	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	403				LGPPVMLDAAT -> TWTPSDALMLQR (in Ref. 1; CAA71366).	multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2						AACTTGGACCCCCAGTGATGC	0.353													T	112112859	T	T	112112859	2	4	59	1	0	0	0	0	0	0	0	1	7553	610	22	3		3	IFRD1	7	112112859	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	13584518	112112859	47025804	50	3839											
GIMAP6	474344	broad.mit.edu	37	chr7	150324938	150324938	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gccctggcttacttgcctttCctgtagttctttcagccgaa	8	13	2	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr7:150324938C>T	uc003whn.2	-	3	1172	c.748G>A	c.(748-750)GAA>AAA	p.E250K	GIMAP6_uc003whm.2_Missense_Mutation_p.E170K	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	250							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACTTGCCTTTCCTGTAGTTCT	0.493													T	150324938	T	T	150324938	3	4	59	1	0	0	0	0	1	0	0	0	6383	864	30	3	134	3	GIMAP6	7	150324938	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	38212079	150324938	8813725	51	3840											
ABP1	26	broad.mit.edu	37	chr7	150558161	150558161	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttcttcccagaggacccctCcctggcatccagagacactg	8	17	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr7:150558161C>T	uc003why.1	+	6	6338	c.2120C>T	c.(2119-2121)TCC>TTC	p.S707F	ABP1_uc003whz.1_Missense_Mutation_p.S707F|ABP1_uc003wia.1_Missense_Mutation_p.S726F	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	707					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	GAGGACCCCTCCCTGGCATCC	0.622													T	150558161	T	T	150558161	3	4	59	1	0	0	0	0	1	0	0	0	98	855	30	3	2134	3	ABP1	7	150558161	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	233223	150558161	8580502	52	3841											
ZMAT4	79698	broad.mit.edu	37	chr8	40554861	40554861	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tcggccaccaccgctgaagtGaatgacatgttgcagagtgt	12	10	0	4			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr8:40554861G>T	uc003xnr.2	-	4	398	c.252C>A	c.(250-252)TTC>TTA	p.F84L	ZMAT4_uc003xns.2_Missense_Mutation_p.F84L	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	84	Matrin-type 2.					nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			CCGCTGAAGTGAATGACATGT	0.498													T	40554861	T	T	40554861	3	4	59	1	0	0	0	0	1	0	0	0	17691	1281	45	5	453	5	ZMAT4	8	40554861	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08		40554861	105809161	53	3842											
MCM4	4173	broad.mit.edu	37	chr8	48874694	48874694	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agagggaaccccaagaagtgGtgttaggggcacacctgtga	15	8	0	3			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr8:48874694G>C	uc003xqk.1	+	4	412	c.317G>C	c.(316-318)GGT>GCT	p.G106A	PRKDC_uc003xqi.2_5'Flank|PRKDC_uc003xqj.2_5'Flank|PRKDC_uc011ldh.1_5'Flank|MCM4_uc003xql.1_Missense_Mutation_p.G106A|MCM4_uc011ldi.1_Missense_Mutation_p.G93A|MCM4_uc010lxw.1_Intron	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	106					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CCAAGAAGTGGTGTTAGGGGC	0.527													C	48874694	C	C	48874694	3	2	59	1	0	0	0	0	1	0	0	0	9389	1261	44	5	327	5	MCM4	8	48874694	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	8319833	48874694	97489328	54	3843											
RPL7	6129	broad.mit.edu	37	chr8	74205020	74205022	+	In_Frame_Del	DEL	CTT	-	-													tctggcacagcaggaacctcCttcttcttctctctaacgtt					rs151181576		TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr8:74205020_74205022delCTT	uc003xzg.2	-	2	47_49	c.25_27delAAG	c.(25-27)AAGdel	p.K9del	RPL7_uc003xzh.1_5'UTR|RDH10_uc003xzi.2_5'Flank	NM_000971	NP_000962	P18124	RL7_HUMAN	ribosomal protein L7	9	1.|4 X 12 AA tandem repeats.				endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|mRNA binding|protein homodimerization activity|structural constituent of ribosome				0	Breast(64;0.0954)		Epithelial(68;0.0193)|all cancers(69;0.0766)|BRCA - Breast invasive adenocarcinoma(89;0.134)			CAGGAACCTCCTTCTTCTTCTCT	0.414													-	74205022	-	-	74205020	7	5	59	1	0	1	0	1	0	0	0	0	13599	680	24	0	739	0	RPL7	8	74205020	In_Frame_Del	DEL	CTT	TCGA-06-0743-01A-01D-1492-08	25330326	74205020	72159002	55	3844											
VPS13B	157680	broad.mit.edu	37	chr8	100568723	100568723	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgagatcctggatcagaaatCgaagacagacaataccaaat	8	9	1	4			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr8:100568723C>T	uc003yiv.2	+	31	4977	c.4866C>T	c.(4864-4866)ATC>ATT	p.I1622I	VPS13B_uc003yiw.2_Silent_p.I1597I	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1622					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GATCAGAAATCGAAGACAGAC	0.398													T	100568723	T	T	100568723	2	4	59	1	0	0	0	0	0	0	0	1	17187	874	31	2		2	VPS13B	8	100568723	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	26363703	100568723	45795299	56	3845											
CSMD3	114788	broad.mit.edu	37	chr8	113702122	113702122	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatgggtatgtttgcagaCcattggttattctcttgaca	10	7	1	3			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr8:113702122C>T	uc003ynu.2	-	14	2289	c.2130G>A	c.(2128-2130)TGG>TGA	p.W710*	CSMD3_uc003yns.2_5'UTR|CSMD3_uc003ynt.2_Nonsense_Mutation_p.W670*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.W606*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	710	Extracellular (Potential).|Sushi 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGTTTGCAGACCATTGGTTAT	0.358										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			T	113702122	T	T	113702122	4	4	59	1	0	0	0	0	0	1	0	0	3946	508	18	3	9225	3	CSMD3	8	113702122	Nonsense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	13133399	113702122	32661900	57	3846											
DENND4C	55667	broad.mit.edu	37	chr9	19360386	19360386	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctttcatcaatcaacatccaAtcattttctggaacctcgtt	3	12	5	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr9:19360386A>G	uc003znq.2	+	24	4483	c.4450A>G	c.(4450-4452)ATC>GTC	p.I1484V	DENND4C_uc011lnc.1_Missense_Mutation_p.I814V|DENND4C_uc011lnd.1_Missense_Mutation_p.I772V|DENND4C_uc003znr.2_Missense_Mutation_p.I772V|DENND4C_uc003zns.2_Missense_Mutation_p.I666V	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1484						integral to membrane				ovary(1)|skin(1)	2						TCAACATCCAATCATTTTCTG	0.388													G	19360386	G	G	19360386	3	3	59	1	0	0	0	0	1	0	0	0	4435	101	4	4	4544	4	DENND4C	9	19360386	Missense_Mutation	SNP	A	TCGA-06-0743-01A-01D-1492-08		19360386	121853045	58	3847											
C9orf84	158401	broad.mit.edu	37	chr9	114462255	114462255	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttacatccagttcttcagaGtttagcccaaatgaaaccaa	5	10	2	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr9:114462255G>A	uc004bfr.2	-	22	3105	c.2970C>T	c.(2968-2970)AAC>AAT	p.N990N	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Silent_p.N951N|C9orf84_uc010mug.2_Silent_p.N901N	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	990										ovary(2)	2						GTTCTTCAGAGTTTAGCCCAA	0.313													A	114462255	A	A	114462255	2	1	59	1	0	0	0	0	0	0	0	1	2500	1020	36	3		3	C9orf84	9	114462255	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08	95101869	114462255	26751176	59	3848											
LRIT1	26103	broad.mit.edu	37	chr10	85992166	85992166	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgctgcccaaagaccgcGtagaggacactgaaggcagt	13	11	0	3	rs142074653	byFrequency	TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr10:85992166G>A	uc001kcz.1	-	4	1411	c.1389C>T	c.(1387-1389)TAC>TAT	p.Y463Y		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	463	Fibronectin type-III.|Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						CAAAGACCGCGTAGAGGACAC	0.582													A	85992166	A	A	85992166	2	1	59	1	0	0	0	0	0	0	0	1	8947	1140	40	1		1	LRIT1	10	85992166	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08		85992166	49542581	60	3849											
PTEN	5728	broad.mit.edu	37	chr10	89692785	89692785	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacagttgcacaatatccttTtgaagaccataacccaccac	4	14	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr10:89692785T>C	uc001kfb.2	+	6	1300	c.269T>C	c.(268-270)TTT>TCT	p.F90S		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	90	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.F90fs*9(5)|p.R55fs*1(4)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.F90L(1)|p.F90S(1)|p.Q87_P96del(1)|p.N82_P95del(1)|p.F90_P95>L(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CAATATCCTTTTGAAGACCAT	0.338		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89692785	C	C	89692785	3	2	59	1	0	0	0	0	1	0	0	0	12738	1841	64	4	287	4	PTEN	10	89692785	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	3700619	89692785	45841962	61	3850											
PTEN	5728	broad.mit.edu	37	chr10	89720847	89720847	+	Frame_Shift_Del	DEL	C	-	-													caaagcaaataaagacaaagCcaaccgatacttttctccaa							TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr10:89720847delC	uc001kfb.2	+	9	2029	c.998delC	c.(997-999)GCCfs	p.A333fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	333	C2 tensin-type.			KANKDKANR->AAGADAANA: Reduces growth suppression activity and promotes anchorage-independent growth. Reduces binding to phospholipid membranes in vitro; phosphatase activity towards PtdIns(3,4,5)P3 is not affected.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.G165_K342del(1)|p.W274_F341del(1)|p.D326_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AAAGACAAAGCCAACCGATAC	0.328		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89720847	-	-	89720847	7	5	59	1	0	1	0	1	0	0	0	0	12738	739	26	0	1028	0	PTEN	10	89720847	Frame_Shift_Del	DEL	C	TCGA-06-0743-01A-01D-1492-08	28062	89720847	45813900	62	3851											
SORCS1	114815	broad.mit.edu	37	chr10	108923743	108923743	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tcacgctgctgttgtggccaGaccagtggaccatggcttgg	14	11	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr10:108923743G>C	uc001kym.2	-	1	550	c.542C>G	c.(541-543)TCT>TGT	p.S181C	SORCS1_uc001kyl.2_Missense_Mutation_p.S181C|SORCS1_uc009xxs.2_Missense_Mutation_p.S181C|SORCS1_uc001kyn.1_Missense_Mutation_p.S181C|SORCS1_uc001kyo.2_Missense_Mutation_p.S181C	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	181	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GTTGTGGCCAGACCAGTGGAC	0.562													C	108923743	C	C	108923743	3	2	59	1	0	0	0	0	1	0	0	0	14930	942	33	5	3302	5	SORCS1	10	108923743	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	19202896	108923743	26611004	63	3852											
SMC3	9126	broad.mit.edu	37	chr10	112344031	112344031	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aaagaagaaagggataagtgGattaaaaaggaactcaagtc	11	3	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr10:112344031G>T	uc001kze.2	+	13	1308	c.1182G>T	c.(1180-1182)TGG>TGT	p.W394C		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	394	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GGGATAAGTGGATTAAAAAGG	0.383													T	112344031	T	T	112344031	3	4	59	1	0	0	0	0	1	0	0	0	14784	1183	41	5	1232	5	SMC3	10	112344031	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	3420288	112344031	23190716	64	3853											
DMBT1	1755	broad.mit.edu	37	chr10	124399762	124399762	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccagtatggcaattttgaCgtgaacatttccttttatac	7	8	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr10:124399762C>T	uc001lgk.1	+	52	6868	c.6762C>T	c.(6760-6762)GAC>GAT	p.D2254D	DMBT1_uc001lgl.1_Silent_p.D2244D|DMBT1_uc001lgm.1_Silent_p.D1626D|DMBT1_uc009xzz.1_Silent_p.D2253D|DMBT1_uc010qtx.1_Silent_p.D974D|DMBT1_uc009yab.1_Silent_p.D957D|DMBT1_uc009yac.1_Silent_p.D548D	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2254	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCAATTTTGACGTGAACATTT	0.463													T	124399762	T	T	124399762	2	4	59	1	0	0	0	0	0	0	0	1	4577	535	19	1		1	DMBT1	10	124399762	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	12055731	124399762	11134985	65	3854											
MUC5B	727897	broad.mit.edu	37	chr11	1267425	1267425	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actccggagaccacccacacCtccacagtgctgaccacgaa	7	18	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr11:1267425C>T	uc009ycr.1	+	49	11190	c.11064C>T	c.(11062-11064)ACC>ACT	p.T3688T	MUC5B_uc001ltb.2_Silent_p.T3108T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3105	7 X Cys-rich subdomain repeats.|Thr-rich.|17 X approximate tandem repeats, Ser/Thr- rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACCCACACCTCCACAGTGC	0.637													T	1267425	T	T	1267425	2	4	59	1	0	0	0	0	0	0	0	1	9979	668	24	3		3	MUC5B	11	1267425	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08		1267425	133739091	66	3855											
MUC5B	727897	broad.mit.edu	37	chr11	1267929	1267929	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccctcctctactccagagacTgtccacacctccacagtgct	5	19	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr11:1267929T>C	uc009ycr.1	+	49	11694	c.11568T>C	c.(11566-11568)ACT>ACC	p.T3856T	MUC5B_uc001ltb.2_Silent_p.T3276T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3273	7 X Cys-rich subdomain repeats.|Thr-rich.|17 X approximate tandem repeats, Ser/Thr- rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCCAGAGACTGTCCACACCT	0.642													C	1267929	C	C	1267929	2	2	59	1	0	0	0	0	0	0	0	1	9979	1567	55	4		4	MUC5B	11	1267929	Silent	SNP	T	TCGA-06-0743-01A-01D-1492-08	504	1267929	133738587	67	3856											
MUC5B	727897	broad.mit.edu	37	chr11	1271196	1271196	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actccggagaccacccacacCtccacagtgctgaccacgaa	7	18	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr11:1271196C>T	uc009ycr.1	+	51	14631	c.14505C>T	c.(14503-14505)ACC>ACT	p.T4835T	MUC5B_uc001ltb.2_Silent_p.T4365T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4362	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACCCACACCTCCACAGTGC	0.652													T	1271196	T	T	1271196	2	4	59	1	0	0	0	0	0	0	0	1	9979	668	24	3		3	MUC5B	11	1271196	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	3267	1271196	133735320	68	3857											
PAMR1	25891	broad.mit.edu	37	chr11	35454286	35454286	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agccagccacagtgatgtggGactcctggaaggaagtgctg	15	9	0	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr11:35454286G>A	uc001mwg.2	-	11	1824	c.1781C>T	c.(1780-1782)TCC>TTC	p.S594F	PAMR1_uc001mwf.2_Missense_Mutation_p.S611F|PAMR1_uc010rew.1_Missense_Mutation_p.S483F|PAMR1_uc010rex.1_Missense_Mutation_p.S554F	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	594	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						AGTGATGTGGGACTCCTGGAA	0.607													A	35454286	A	A	35454286	3	1	59	1	0	0	0	0	1	0	0	0	11413	1174	41	3	385	3	PAMR1	11	35454286	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	34183090	35454286	99552230	69	3858											
LRP4	4038	broad.mit.edu	37	chr11	46880763	46880763	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggaggcccccccgtgagcttCgcagttgcttgaggtcatcc	13	14	1	2	rs146864522		TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr11:46880763C>T	uc001ndn.3	-	38	5635	c.5489G>A	c.(5488-5490)CGA>CAA	p.R1830Q	uc001ndl.2_Intron|LRP4_uc001ndm.3_Missense_Mutation_p.R72Q	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1830	Cytoplasmic (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CCGTGAGCTTCGCAGTTGCTT	0.572													T	46880763	T	T	46880763	3	4	59	1	0	0	0	0	1	0	0	0	8959	884	31	2	232	2	LRP4	11	46880763	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	11426477	46880763	88125753	70	3859											
UNC93B1	81622	broad.mit.edu	37	chr11	67765211	67765211	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaatgaggtttccgctccgCgggagcgtccgcagaaccgt	13	13	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr11:67765211C>T	uc001omw.1	-	7	920	c.840G>A	c.(838-840)CCG>CCA	p.P280P		NM_030930	NP_112192	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1	280					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome					0						TTCCGCTCCGCGGGAGCGTCC	0.647													T	67765211	T	T	67765211	2	4	59	1	0	0	0	0	0	0	0	1	16994	755	27	1		1	UNC93B1	11	67765211	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	20884448	67765211	67241305	71	3860											
CNTN5	53942	broad.mit.edu	37	chr11	100126601	100126601	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agcccaatctcctcctacaaCcttcaagctcgcagcccatt	4	18	2	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr11:100126601C>A	uc001pga.2	+	17	2454	c.2115C>A	c.(2113-2115)AAC>AAA	p.N705K	CNTN5_uc001pfz.2_Missense_Mutation_p.N705K|CNTN5_uc001pgb.2_Missense_Mutation_p.N631K|CNTN5_uc010ruk.1_5'UTR	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	705	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCTCCTACAACCTTCAAGCTC	0.507													A	100126601	A	A	100126601	3	1	59	1	0	0	0	0	1	0	0	0	3644	506	18	5	2173	5	CNTN5	11	100126601	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	32361390	100126601	34879915	72	3861											
CACNA2D4	93589	broad.mit.edu	37	chr12	1992139	1992139	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacgttctcctgggtgtccGccagcgttgagatctgcgtg	13	12	3	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr12:1992139G>A	uc001qjp.2	-	13	1610	c.1379C>T	c.(1378-1380)GCG>GTG	p.A460V	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.A348V	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	460	VWFA.|Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CTGGGTGTCCGCCAGCGTTGA	0.632													A	1992139	A	A	1992139	3	1	59	1	0	0	0	0	1	0	0	0	2551	1087	38	1	2138	1	CACNA2D4	12	1992139	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08		1992139	131859756	73	3862											
PTPRO	5800	broad.mit.edu	37	chr12	15654855	15654855	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgtacttcccatggaataCgaaaataacagtacactcag	7	10	1	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr12:15654855C>T	uc001rcv.1	+	5	1137	c.963C>T	c.(961-963)TAC>TAT	p.Y321Y	PTPRO_uc001rcw.1_Silent_p.Y321Y|PTPRO_uc001rcu.1_Silent_p.Y321Y	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	321	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				CCATGGAATACGAAAATAACA	0.448													T	15654855	T	T	15654855	2	4	59	1	0	0	0	0	0	0	0	1	12809	547	19	1		1	PTPRO	12	15654855	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	13662716	15654855	118197040	74	3863											
MLL2	8085	broad.mit.edu	37	chr12	49416373	49416373	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcccctctgccagctcatacCtgctcttcgtagattttctc	6	16	4	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr12:49416373C>G	uc001rta.3	-	51	16338	c.16338G>C	c.(16336-16338)CAG>CAC	p.Q5446H		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5446	SET.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAGCTCATACCTGCTCTTCGT	0.542			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			G	49416373	G	G	49416373	3	3	59	1	0	0	0	0	1	0	0	0	9621	695	24	5	291	5	MLL2	12	49416373	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	33761518	49416373	84435522	75	3864											
MLL2	8085	broad.mit.edu	37	chr12	49432216	49432216	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagggccagaggattggggcGgccaagctcagtgctcgacg	17	11	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr12:49432216G>A	uc001rta.3	-	34	8923	c.8923C>T	c.(8923-8925)CGC>TGC	p.R2975C		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2975	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGATTGGGGCGGCCAAGCTCA	0.577			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			A	49432216	A	A	49432216	3	1	59	1	0	0	0	0	1	0	0	0	9621	1116	39	2	7774	2	MLL2	12	49432216	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	15843	49432216	84419679	76	3865											
KCNH3	23416	broad.mit.edu	37	chr12	49935518	49935518	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	catcagcgaaaccaagaaccGagggggccccgacagatgga	13	12	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr12:49935518G>A	uc001ruh.1	+	3	676	c.416G>A	c.(415-417)CGA>CAA	p.R139Q	KCNH3_uc010smj.1_Missense_Mutation_p.R79Q	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	139	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						ACCAAGAACCGAGGGGGCCCC	0.592													A	49935518	A	A	49935518	3	1	59	1	0	0	0	0	1	0	0	0	8033	1058	37	2	426	2	KCNH3	12	49935518	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	503302	49935518	83916377	77	3866											
CRADD	8738	broad.mit.edu	37	chr12	94243772	94243772	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gattgactgggatcccctcgCacatcctcaacagctcccca	7	17	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr12:94243772C>A	uc001tda.2	+	3	429	c.325C>A	c.(325-327)CAC>AAC	p.H109N	CRADD_uc010sur.1_Intron|CRADD_uc010sus.1_Intron	NM_003805	NP_003796	P78560	CRADD_HUMAN	CASP2 and RIPK1 domain containing adaptor with	109					apoptosis|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|signal transduction	intracellular	death domain binding|protease binding|protein binding, bridging			ovary(1)	1						GATCCCCTCGCACATCCTCAA	0.562													A	94243772	A	A	94243772	3	1	59	1	0	0	0	0	1	0	0	0	3845	710	25	5	331	5	CRADD	12	94243772	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	44308254	94243772	39608123	78	3867											
CUX2	23316	broad.mit.edu	37	chr12	111748245	111748245	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggcagaggaggagcagctGgacacggcagagatcgcctt	18	9	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr12:111748245G>A	uc001tsa.1	+	15	1812	c.1659G>A	c.(1657-1659)CTG>CTA	p.L553L		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	553	CUT 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						AGGAGCAGCTGGACACGGCAG	0.701													A	111748245	A	A	111748245	2	1	59	1	0	0	0	0	0	0	0	1	4065	1335	47	3		3	CUX2	12	111748245	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08	17504473	111748245	22103650	79	3868											
GPR133	283383	broad.mit.edu	37	chr12	131487822	131487822	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagcacgccccaggtcacCgtggagggctcctctgccat	13	16	2	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr12:131487822C>T	uc001uit.3	+	10	1678	c.1119C>T	c.(1117-1119)ACC>ACT	p.T373T	GPR133_uc010tbm.1_Silent_p.T405T	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	373	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CCCAGGTCACCGTGGAGGGCT	0.612													T	131487822	T	T	131487822	2	4	59	1	0	0	0	0	0	0	0	1	6643	639	23	2		2	GPR133	12	131487822	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	19739577	131487822	2364073	80	3869											
TPTE2	93492	broad.mit.edu	37	chr13	20039688	20039688	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aataataagtcgtagaagtcGaactaaatgtgtccatctaa	7	6	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr13:20039688G>A	uc001umd.2	-	9	740	c.529C>T	c.(529-531)CGA>TGA	p.R177*	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Nonsense_Mutation_p.R66*|TPTE2_uc001ume.2_Nonsense_Mutation_p.R100*|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	177						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CGTAGAAGTCGAACTAAATGT	0.289													A	20039688	A	A	20039688	4	1	59	1	0	0	0	0	0	1	0	0	16428	1066	37	2	1091	2	TPTE2	13	20039688	Nonsense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08		20039688	95130190	81	3870											
SPERT	220082	broad.mit.edu	37	chr13	46287387	46287387	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgctgcgcgcagcaggccgCcctgccccggctgagccgca	14	19	0	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr13:46287387C>T	uc001van.1	+	3	307	c.227C>T	c.(226-228)GCC>GTC	p.A76V	SPERT_uc001vao.2_Missense_Mutation_p.A40V	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	76						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CAGCAGGCCGCCCTGCCCCGG	0.662													T	46287387	T	T	46287387	3	4	59	1	0	0	0	0	1	0	0	0	15038	739	26	3	237	3	SPERT	13	46287387	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	26247699	46287387	68882491	82	3871											
STRN3	29966	broad.mit.edu	37	chr14	31425409	31425409	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	taagtccttcttcaggttctCttgaccttttctttcgcctt	5	12	4	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr14:31425409C>A	uc001wqu.2	-	2	538	c.322G>T	c.(322-324)GAG>TAG	p.E108*	STRN3_uc001wqv.2_Nonsense_Mutation_p.E108*|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	108	Potential.				negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TTCAGGTTCTCTTGACCTTTT	0.328													A	31425409	A	A	31425409	4	1	59	1	0	0	0	0	0	1	0	0	15329	922	32	5	2139	5	STRN3	14	31425409	Nonsense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08		31425409	75924131	83	3872											
MAX	4149	broad.mit.edu	37	chr14	65543330	65543330	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggctgttgtctgaggagGggtagttggtctgcagttgg	19	4	2	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr14:65543330G>A	uc001xif.1	-	5	517	c.347C>T	c.(346-348)CCC>CTC	p.P116L	MAX_uc001xic.1_Intron|MAX_uc001xie.1_3'UTR|MAX_uc010aql.1_Missense_Mutation_p.P30S|MAX_uc001xig.1_Missense_Mutation_p.P107L|MAX_uc001xih.1_RNA	NM_002382	NP_002373	P61244	MAX_HUMAN	MAX protein isoform a	116					transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GTCTGAGGAGGGGTAGTTGGT	0.587													A	65543330	A	A	65543330	3	1	59	1	0	0	0	0	1	0	0	0	9339	1232	43	3	224	3	MAX	14	65543330	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	34117921	65543330	41806210	84	3873											
PIF1	80119	broad.mit.edu	37	chr15	65114493	65114493	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcatggagggtggtgcccccGatgtggcaggctgccacccc	16	14	0	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr15:65114493G>A	uc002ant.2	-	4	855	c.789C>T	c.(787-789)ATC>ATT	p.I263I	PIF1_uc002anr.2_5'Flank|PIF1_uc002ans.2_5'Flank|PIF1_uc010uiq.1_Silent_p.I263I|PIF1_uc002anu.2_3'UTR	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	DNA helicase homolog PIF1	263	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0						TGGTGCCCCCGATGTGGCAGG	0.612													A	65114493	A	A	65114493	2	1	59	1	0	0	0	0	0	0	0	1	11883	1048	37	2		2	PIF1	15	65114493	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08		65114493	37416899	85	3874											
PPL	5493	broad.mit.edu	37	chr16	4937215	4937215	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaacttcagtgaacttggcgGcaagtgctgcttcctgcaga	11	10	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr16:4937215G>A	uc002cyd.1	-	21	2618	c.2528C>T	c.(2527-2529)GCC>GTC	p.A843V		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	843	Spectrin 4.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GAACTTGGCGGCAAGTGCTGC	0.483													A	4937215	A	A	4937215	3	1	59	1	0	0	0	0	1	0	0	0	12334	1203	42	3	2750	3	PPL	16	4937215	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08		4937215	85417538	86	3875											
GLG1	2734	broad.mit.edu	37	chr16	74542799	74542799	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaatttgggatctgtagttaGgttcagcttataattccaca	8	6	2	0	rs142819854		TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr16:74542799G>C	uc002fcy.3	-	3	546	c.496C>G	c.(496-498)CTA>GTA	p.L166V	GLG1_uc002fcx.2_Missense_Mutation_p.L166V|GLG1_uc002fcw.3_Missense_Mutation_p.L155V|GLG1_uc002fcz.3_5'UTR	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	166	Cys-rich GLG1 2.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						TCTGTAGTTAGGTTCAGCTTA	0.328													C	74542799	C	C	74542799	3	2	59	1	0	0	0	0	1	0	0	0	6436	991	35	5	3219	5	GLG1	16	74542799	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	69605584	74542799	15811954	87	3876											
CBFA2T3	863	broad.mit.edu	37	chr16	88945844	88945844	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagctccgacatggcctgcCgcttcacctcattcacggcc	9	18	3	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr16:88945844C>T	uc002fmm.1	-	11	1682	c.1496G>A	c.(1495-1497)CGG>CAG	p.R499Q	CBFA2T3_uc002fml.1_Missense_Mutation_p.R413Q|CBFA2T3_uc002fmk.1_5'UTR	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	499	Mediates interaction with PRKAR2A.|Potential.				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CATGGCCTGCCGCTTCACCTC	0.647			T	RUNX1	AML								T	88945844	T	T	88945844	3	4	59	1	0	0	0	0	1	0	0	0	2698	652	23	2	473	2	CBFA2T3	16	88945844	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	14403045	88945844	1408909	88	3877											
P2RX5	5026	broad.mit.edu	37	chr17	3582918	3582918	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagctgtgggcacacagatcCgttccccttctgactgctgc	11	14	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr17:3582918C>T	uc002fwi.2	-	11	1509	c.1225G>A	c.(1225-1227)GGA>AGA	p.G409R	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Missense_Mutation_p.G408R|P2RX5_uc010vrx.1_Missense_Mutation_p.G349R|P2RX5_uc002fwj.2_Missense_Mutation_p.G384R|P2RX5_uc002fwk.2_Missense_Mutation_p.G408R|P2RX5_uc002fwl.2_Missense_Mutation_p.G385R	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	409	Cytoplasmic (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						CACACAGATCCGTTCCCCTTC	0.672													T	3582918	T	T	3582918	3	4	59	1	0	0	0	0	1	0	0	0	11343	661	23	2	51	2	P2RX5	17	3582918	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08		3582918	77612292	89	3878											
RABEP1	9135	broad.mit.edu	37	chr17	5238607	5238607	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gaaggctgtctgaaggtcaaGaggaggaaaatttagaaaat	13	3	2	3			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr17:5238607G>A	uc002gbm.3	+	4	720	c.496G>A	c.(496-498)GAG>AAG	p.E166K	RABEP1_uc010clc.1_Missense_Mutation_p.E166K|RABEP1_uc010cld.1_Missense_Mutation_p.E123K|RABEP1_uc010vsw.1_Missense_Mutation_p.E123K|RABEP1_uc002gbl.3_Missense_Mutation_p.E166K|RABEP1_uc002gbj.2_Missense_Mutation_p.E166K|RABEP1_uc002gbk.2_Missense_Mutation_p.E166K	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	166	Potential.				apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2						TGAAGGTCAAGAGGAGGAAAA	0.383													A	5238607	A	A	5238607	3	1	59	1	0	0	0	0	1	0	0	0	12961	943	33	3	510	3	RABEP1	17	5238607	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	1655689	5238607	75956603	90	3879											
TP53	7157	broad.mit.edu	37	chr17	7578394	7578394	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgctatctgagcagcgctcaTggtgggggcagcgcctcaca	14	13	3	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr17:7578394T>C	uc002gim.2	-	5	730	c.536A>G	c.(535-537)CAT>CGT	p.H179R	TP53_uc002gig.1_Missense_Mutation_p.H179R|TP53_uc002gih.2_Missense_Mutation_p.H179R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47R|TP53_uc010cng.1_Missense_Mutation_p.H47R|TP53_uc002gii.1_Missense_Mutation_p.H47R|TP53_uc010cnh.1_Missense_Mutation_p.H179R|TP53_uc010cni.1_Missense_Mutation_p.H179R|TP53_uc002gij.2_Missense_Mutation_p.H179R|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86R|TP53_uc002gio.2_Missense_Mutation_p.H47R|TP53_uc010vug.1_Missense_Mutation_p.H140R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578394	C	C	7578394	3	2	59	1	0	0	0	0	1	0	0	0	16378	1464	51	4	762	4	TP53	17	7578394	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	2339787	7578394	73616816	91	3880											
PEX12	5193	broad.mit.edu	37	chr17	33904306	33904306	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gggaagaagggggatgaataGaatattcatcctcttctctc	11	7	3	3			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr17:33904306G>C	uc002hjp.2	-	2	1047	c.431C>G	c.(430-432)TCT>TGT	p.S144C		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	144	Cytoplasmic (Potential).				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGGATGAATAGAATATTCATC	0.453													C	33904306	C	C	33904306	3	2	59	1	0	0	0	0	1	0	0	0	11740	942	33	5	656	5	PEX12	17	33904306	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	26325912	33904306	47290904	92	3881											
KRT38	8687	broad.mit.edu	37	chr17	39593757	39593757	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagcacagggggcagtcacGcaggagggagacgtggagca	20	8	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr17:39593757G>A	uc002hwq.1	-	7	1701	c.1278C>T	c.(1276-1278)TGC>TGT	p.C426C		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	426	Tail.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				GGGCAGTCACGCAGGAGGGAG	0.617													A	39593757	A	A	39593757	2	1	59	1	0	0	0	0	0	0	0	1	8475	1079	38	1		1	KRT38	17	39593757	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08	5689451	39593757	41601453	93	3882											
CCBE1	147372	broad.mit.edu	37	chr18	57106776	57106776	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaccactcataaggcttaccTtagaaccatctcttcctggt	6	13	2	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr18:57106776T>G	uc002lib.2	-	9	1020	c.950A>C	c.(949-951)AAG>ACG	p.K317T	CCBE1_uc010dpq.2_Missense_Mutation_p.K46T|CCBE1_uc002lia.2_Missense_Mutation_p.K170T	NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	317	Collagen-like 2.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				AAGGCTTACCTTAGAACCATC	0.348													G	57106776	G	G	57106776	3	3	59	1	0	0	0	0	1	0	0	0	2731	1623	56	5	282	5	CCBE1	18	57106776	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08		57106776	20970472	94	3883											
ADNP2	22850	broad.mit.edu	37	chr18	77896514	77896514	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atatcctagtaaaaaggaaaTagaactgttgtcctcactct	6	8	2	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr18:77896514T>C	uc002lnw.2	+	4	3673	c.3218T>C	c.(3217-3219)ATA>ACA	p.I1073T		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	1073	Homeobox.				cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		AAAAAGGAAATAGAACTGTTG	0.313													C	77896514	C	C	77896514	3	2	59	1	0	0	0	0	1	0	0	0	324	1406	49	4	3228	4	ADNP2	18	77896514	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	20789738	77896514	180734	95	3884			1	12		2	2	21	T		7.687859e-05
ADNP2	22850	broad.mit.edu	37	chr18	77896534	77896534	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagaactgttgtcctcactcTtttgggtgtggaaaattgat	10	6	2	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr18:77896534T>C	uc002lnw.2	+	4	3693	c.3238T>C	c.(3238-3240)TTT>CTT	p.F1080L		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	1080	Homeobox.				cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GTCCTCACTCTTTTGGGTGTG	0.328													C	77896534	C	C	77896534	3	2	59	1	0	0	0	0	1	0	0	0	324	1609	56	4	3248	4	ADNP2	18	77896534	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	20	77896534	180714	96	3885			1	12		2	2	21	T		7.687859e-05
GCDH	2639	broad.mit.edu	37	chr19	13008135	13008135	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggatgcagtttggtgtcccActggccaggaaccagctgat	13	10	0	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr19:13008135A>T	uc002mvq.2	+	10	1052	c.975A>T	c.(973-975)CCA>CCT	p.P325P	GCDH_uc010xms.1_Silent_p.P292P|GCDH_uc002mvp.2_Silent_p.P325P|GCDH_uc010xmt.1_Silent_p.P159P|GCDH_uc010xmu.1_Silent_p.P281P	NM_000159	NP_000150	Q92947	GCDH_HUMAN	glutaryl-Coenzyme A dehydrogenase isoform a	325					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0						TTGGTGTCCCACTGGCCAGGA	0.627													T	13008135	T	T	13008135	2	4	59	1	0	0	0	0	0	0	0	1	6287	146	6	5		5	GCDH	19	13008135	Silent	SNP	A	TCGA-06-0743-01A-01D-1492-08		13008135	46120848	97	3886											
OR10H1	26539	broad.mit.edu	37	chr19	15917903	15917903	+	Frame_Shift_Del	DEL	A	-	-													aatttctcctacatcattacAtttttttctgggtagagttt							TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr19:15917903delA	uc002nbq.2	-	1	1034	c.945delT	c.(943-945)AATfs	p.N315fs		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	315	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACATCATTACATTTTTTTCTG	0.363													-	15917903	-	-	15917903	7	5	59	1	0	1	0	1	0	0	0	0	10905	214	8	0	15	0	OR10H1	19	15917903	Frame_Shift_Del	DEL	A	TCGA-06-0743-01A-01D-1492-08	2909768	15917903	43211080	98	3887											
PDE4C	5143	broad.mit.edu	37	chr19	18327614	18327614	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaggttctggaagatatcGcagttctctgcctgcagcag	12	10	2	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr19:18327614G>A	uc010xqc.1	-	12	1902	c.1422C>T	c.(1420-1422)TGC>TGT	p.C474C	PDE4C_uc002nik.3_Silent_p.C474C|PDE4C_uc002nil.3_Silent_p.C474C|PDE4C_uc002nif.3_Silent_p.C243C|PDE4C_uc002nig.3_Silent_p.C189C|PDE4C_uc002nih.3_Silent_p.C244C|PDE4C_uc010ebk.2_Silent_p.C368C|PDE4C_uc002nii.3_Silent_p.C442C|PDE4C_uc010ebl.2_Silent_p.C188C|PDE4C_uc010xqd.1_Silent_p.C243C	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	474					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	GGAAGATATCGCAGTTCTCTG	0.602													A	18327614	A	A	18327614	2	1	59	1	0	0	0	0	0	0	0	1	11641	1079	38	1		1	PDE4C	19	18327614	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08	2409711	18327614	40801369	99	3888											
CILP2	148113	broad.mit.edu	37	chr19	19653191	19653191	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catatccccccagggtgcagCcttgacacctgtgaatgccc	9	16	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr19:19653191C>T	uc002nmv.3	+	5	685	c.600C>T	c.(598-600)AGC>AGT	p.S200S	CILP2_uc002nmw.3_Silent_p.S206S	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	200						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CAGGGTGCAGCCTTGACACCT	0.582													T	19653191	T	T	19653191	2	4	59	1	0	0	0	0	0	0	0	1	3430	738	26	3		3	CILP2	19	19653191	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	1325577	19653191	39475792	100	3889											
ZNF208	7757	broad.mit.edu	37	chr19	22154854	22154854	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tagggtttctctccagtatgAattaccttatgtttagtaag	8	6	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr19:22154854A>T	uc002nqp.2	-	6	2747	c.2598T>A	c.(2596-2598)ATT>ATA	p.I866I	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTCCAGTATGAATTACCTTAT	0.348													T	22154854	T	T	22154854	2	4	59	1	0	0	0	0	0	0	0	1	17763	242	9	5		5	ZNF208	19	22154854	Silent	SNP	A	TCGA-06-0743-01A-01D-1492-08	2501663	22154854	36974129	101	3890											
MLL4	9757	broad.mit.edu	37	chr19	36222840	36222840	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgaggaccccccactggaCacagatgttcttgtccctgg	12	13	1	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr19:36222840C>T	uc010eei.2	+	28	5469	c.5469C>T	c.(5467-5469)GAC>GAT	p.D1823D		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1823					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCCACTGGACACAGATGTTC	0.627													T	36222840	T	T	36222840	2	4	59	1	0	0	0	0	0	0	0	1	9623	477	17	3		3	MLL4	19	36222840	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	14067986	36222840	22906143	102	3891											
MEGF8	1954	broad.mit.edu	37	chr19	42873137	42873137	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatgagtgcagctgcaagacCggctataccatggacaagtg	12	9	0	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr19:42873137C>T	uc002otl.3	+	36	7058	c.6423C>T	c.(6421-6423)ACC>ACT	p.T2141T	MEGF8_uc002otm.3_Silent_p.T1749T|MEGF8_uc002otn.3_5'Flank	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2208	Extracellular (Potential).|EGF-like 5.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GCTGCAAGACCGGCTATACCA	0.637													T	42873137	T	T	42873137	2	4	59	1	0	0	0	0	0	0	0	1	9463	639	23	2		2	MEGF8	19	42873137	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	6650297	42873137	16255846	103	3892											
ZNF813	126017	broad.mit.edu	37	chr19	53994332	53994332	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgtggcaagactttcagtcaGacgtattcccttacatgcca	8	11	2	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr19:53994332G>A	uc002qbu.2	+	4	974	c.846G>A	c.(844-846)CAG>CAA	p.Q282Q	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	282	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		CTTTCAGTCAGACGTATTCCC	0.418													A	53994332	A	A	53994332	2	1	59	1	0	0	0	0	0	0	0	1	18172	933	33	3		3	ZNF813	19	53994332	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08	11121195	53994332	5134651	104	3893											
SRXN1	140809	broad.mit.edu	37	chr20	629466	629466	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagttgctggtaggccgcGtagcggtggcagcccccaaa	15	12	0	0	rs140166119		TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr20:629466G>A	uc002wea.2	-	2	367	c.306C>T	c.(304-306)TAC>TAT	p.Y102Y	SRXN1_uc002web.2_RNA	NM_080725	NP_542763	Q9BYN0	SRXN1_HUMAN	sulfiredoxin 1 homolog	102					response to oxidative stress	cytosol	antioxidant activity|ATP binding|DNA binding|sulfiredoxin activity			ovary(1)	1						GGTAGGCCGCGTAGCGGTGGC	0.617													A	629466	A	A	629466	2	1	59	1	0	0	0	0	0	0	0	1	15172	1140	40	1		1	SRXN1	20	629466	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08		629466	62396054	105	3894											
PROKR2	128674	broad.mit.edu	37	chr20	5282783	5282783	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctcccccgctgggagggaCgccagtgcagcagcatcatc	13	15	1	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr20:5282783C>T	uc010zqw.1	-	2	1058	c.1058G>A	c.(1057-1059)CGT>CAT	p.R353H	PROKR2_uc010zqx.1_Missense_Mutation_p.R353H|PROKR2_uc010zqy.1_Missense_Mutation_p.R353H	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	353	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CTGGGAGGGACGCCAGTGCAG	0.557										HNSCC(71;0.22)			T	5282783	T	T	5282783	3	4	59	1	0	0	0	0	1	0	0	0	12553	536	19	1	99	1	PROKR2	20	5282783	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	4653317	5282783	57742737	106	3895											
SEL1L2	80343	broad.mit.edu	37	chr20	13899669	13899669	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cactggataaagacttactcTtctttttgtttttggctttt	6	7	2	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr20:13899669T>A	uc010gcf.2	-	4	466	c.384A>T	c.(382-384)GAA>GAT	p.E128D	SEL1L2_uc002woq.3_Translation_Start_Site|SEL1L2_uc010zrl.1_Missense_Mutation_p.E128D|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	128	Extracellular (Potential).|Sel1-like 1.					integral to membrane	binding			ovary(2)	2						AGACTTACTCTTCTTTTTGTT	0.343													A	13899669	A	A	13899669	3	1	59	1	0	0	0	0	1	0	0	0	14011	1606	56	5	1750	5	SEL1L2	20	13899669	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	8616886	13899669	49125851	107	3896											
SPAG4	6676	broad.mit.edu	37	chr20	34206899	34206899	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggattttgtgcggaagcccGactatgctttgagctctgtg	13	8	1	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr20:34206899G>A	uc002xdb.1	+	8	889	c.772G>A	c.(772-774)GAC>AAC	p.D258N	SPAG4_uc010zvi.1_Missense_Mutation_p.D181N	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	258					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			GCGGAAGCCCGACTATGCTTT	0.468													A	34206899	A	A	34206899	3	1	59	1	0	0	0	0	1	0	0	0	14980	1058	37	2	802	2	SPAG4	20	34206899	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	20307230	34206899	28818621	108	3897											
PLCG1	5335	broad.mit.edu	37	chr20	39795447	39795447	+	Missense_Mutation	SNP	T	G	G													acacccgctataccgcaagaTgaagctgcgctatcccatca							TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr20:39795447T>G	uc002xjp.1	+	19	2370	c.2249T>G	c.(2248-2250)ATG>AGG	p.M750R	PLCG1_uc002xjo.1_Missense_Mutation_p.M750R|PLCG1_uc010zwe.1_Missense_Mutation_p.M376R|PLCG1_uc010ggf.2_Missense_Mutation_p.M100R	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	750	SH2 2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				TACCGCAAGATGAAGCTGCGC	0.572													G	39795447	G	G	39795447	3	3	59	1	0	0	0	0	1	0	0	0	12035	1464	51	5	2323	5	PLCG1	20	39795447	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	5588548	39795447	23230073	109	3898	4	2									
PLCG1	5335	broad.mit.edu	37	chr20	39795453	39795453	+	Missense_Mutation	SNP	T	A	A													gctataccgcaagatgaagcTgcgctatcccatcaacgagg							TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr20:39795453T>A	uc002xjp.1	+	19	2376	c.2255T>A	c.(2254-2256)CTG>CAG	p.L752Q	PLCG1_uc002xjo.1_Missense_Mutation_p.L752Q|PLCG1_uc010zwe.1_Missense_Mutation_p.L378Q|PLCG1_uc010ggf.2_Missense_Mutation_p.L102Q	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	752	SH2 2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				AAGATGAAGCTGCGCTATCCC	0.567													A	39795453	A	A	39795453	3	1	59	1	0	0	0	0	1	0	0	0	12035	1580	55	5	2329	5	PLCG1	20	39795453	Missense_Mutation	SNP	T	TCGA-06-0743-01A-01D-1492-08	6	39795453	23230067	110	3899	4	2									
ERG	2078	broad.mit.edu	37	chr21	39795357	39795357	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcacgataactctgcgctcGttcgtggtcatgtttggggg	15	9	2	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr21:39795357G>A	uc010gnw.2	-	5	679	c.384C>T	c.(382-384)AAC>AAT	p.N128N	ERG_uc002yxa.2_Silent_p.N121N|ERG_uc011aek.1_Silent_p.N29N|ERG_uc010gnv.2_Silent_p.N29N|ERG_uc010gnx.2_Silent_p.N128N|ERG_uc011ael.1_Silent_p.N128N|ERG_uc002yxb.2_Silent_p.N128N|ERG_uc011aem.1_Silent_p.N121N|ERG_uc002yxc.3_Silent_p.N128N	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	128	PNT.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CTCTGCGCTCGTTCGTGGTCA	0.602													A	39795357	A	A	39795357	2	1	59	1	0	0	0	0	0	0	0	1	5222	1136	40	1		1	ERG	21	39795357	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08		39795357	8334538	111	3900											
UBASH3A	53347	broad.mit.edu	37	chr21	43867265	43867265	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accctgacccacggggcgaaCgcagcatttaactggaggaa	12	12	0	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr21:43867265C>T	uc002zbe.2	+	15	1983	c.1947C>T	c.(1945-1947)AAC>AAT	p.N649N	UBASH3A_uc002zbf.2_Silent_p.N611N|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_3'UTR	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	649	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						ACGGGGCGAACGCAGCATTTA	0.527													T	43867265	T	T	43867265	2	4	59	1	0	0	0	0	0	0	0	1	16836	535	19	1		1	UBASH3A	21	43867265	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	4071908	43867265	4262630	112	3901											
GAL3ST1	9514	broad.mit.edu	37	chr22	30951882	30951882	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtcgaagtcattgcggccGttagggaaggcgaacttgag	15	7	1	1	rs112070427	byFrequency	TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chr22:30951882G>A	uc003aig.1	-	4	470	c.330C>T	c.(328-330)AAC>AAT	p.N110N	GAL3ST1_uc003aih.1_Silent_p.N110N|GAL3ST1_uc003aii.1_Silent_p.N110N|GAL3ST1_uc010gvz.1_Silent_p.N110N	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	110	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CATTGCGGCCGTTAGGGAAGG	0.597													A	30951882	A	A	30951882	2	1	59	1	0	0	0	0	0	0	0	1	6197	1136	40	1		1	GAL3ST1	22	30951882	Silent	SNP	G	TCGA-06-0743-01A-01D-1492-08		30951882	20352684	113	3902											
P2RY8	286530	broad.mit.edu	37	chrX	1584686	1584686	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgatgtgcgccaggagcaCgaagttgttgggggcgaagc	17	9	0	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chrX:1584686C>T	uc004cpz.2	-	2	1014	c.766G>A	c.(766-768)GTG>ATG	p.V256M		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	256	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCCAGGAGCACGAAGTTGTTG	0.647			T	CRLF2	B-ALL|Downs associated ALL								T	1584686	T	T	1584686	3	4	59	1	0	0	0	0	1	0	0	0	11355	536	19	1	317	1	P2RY8	23	1584686	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08		1584686	153685874	114	3903											
FOXR2	139628	broad.mit.edu	37	chrX	55650462	55650462	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaaagaggatctgacaaaCatttctcctttccctcagcc	7	12	3	2			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chrX:55650462C>T	uc004duo.2	+	1	630	c.318C>T	c.(316-318)AAC>AAT	p.N106N		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	106					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						ATCTGACAAACATTTCTCCTT	0.542													T	55650462	T	T	55650462	2	4	59	1	0	0	0	0	0	0	0	1	6032	477	17	3		3	FOXR2	23	55650462	Silent	SNP	C	TCGA-06-0743-01A-01D-1492-08	54065776	55650462	99620098	115	3904											
MUM1L1	139221	broad.mit.edu	37	chrX	105450617	105450617	+	Frame_Shift_Del	DEL	T	-	-													aaacaggaatgatagtctggTttaaatatcagaaatatcca							TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chrX:105450617delT	uc004emf.1	+	4	1841	c.1192delT	c.(1192-1194)TTTfs	p.F398fs	MUM1L1_uc004emg.1_Frame_Shift_Del_p.F398fs	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	398	PWWP.									ovary(2)|pancreas(1)|skin(1)	4						GATAGTCTGGTTTAAATATCA	0.358													-	105450617	-	-	105450617	7	5	59	1	0	1	0	1	0	0	0	0	9986	1725	60	0	1194	0	MUM1L1	23	105450617	Frame_Shift_Del	DEL	T	TCGA-06-0743-01A-01D-1492-08	49800155	105450617	49819943	116	3905											
AGTR2	186	broad.mit.edu	37	chrX	115304521	115304521	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accggttccaacagaagctcCgcagtgtgtttagggttcca	11	11	0	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chrX:115304521C>T	uc004eqh.3	+	3	1195	c.988C>T	c.(988-990)CGC>TGC	p.R330C		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	330	Cytoplasmic (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						ACAGAAGCTCCGCAGTGTGTT	0.463													T	115304521	T	T	115304521	3	4	59	1	0	0	0	0	1	0	0	0	402	652	23	2	990	2	AGTR2	23	115304521	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	9853904	115304521	39966039	117	3906											
MAGEC3	139081	broad.mit.edu	37	chrX	140966989	140966989	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaccctatcagggtccccagGtttacaactttctgacttgc	8	13	2	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chrX:140966989G>C	uc011mwp.1	+	3	287	c.287G>C	c.(286-288)GGT>GCT	p.G96A		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	96										skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGGTCCCCAGGTTTACAACTT	0.582													C	140966989	C	C	140966989	3	2	59	1	0	0	0	0	1	0	0	0	9182	1261	44	5	297	5	MAGEC3	23	140966989	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08	25662468	140966989	14303571	118	3907											
FLNA	2316	broad.mit.edu	37	chrX	153588445	153588445	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgctggggaagttgggcaCgggctggccgccgtacttga	17	10	0	1			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chrX:153588445C>T	uc004fkk.2	-	22	3967	c.3718G>A	c.(3718-3720)GTG>ATG	p.V1240M	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Missense_Mutation_p.V1240M	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1240	Filamin 10.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AAGTTGGGCACGGGCTGGCCG	0.627													T	153588445	T	T	153588445	3	4	59	1	0	0	0	0	1	0	0	0	5933	536	19	1	4333	1	FLNA	23	153588445	Missense_Mutation	SNP	C	TCGA-06-0743-01A-01D-1492-08	12621456	153588445	1682115	119	3908											
PCDH11Y	83259	broad.mit.edu	37	chrY	5605460	5605460	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggcctctgctctatgccacaGcccaccactgtcacaggcct	8	18	3	0			TCGA-06-0743-01A-01D-1492-08	TCGA-06-0743-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	430e6ca1-d678-4373-8d8d-9d93412c8012	0c87c515-10e3-4b7d-8adb-6c88f04c6a22	g.chrY:5605460G>T	uc004fqo.2	+	5	4234	c.3500G>T	c.(3499-3501)AGC>ATC	p.S1167I		NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	1167	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						CTATGCCACAGCCCACCACTG	0.552													T	5605460	T	T	5605460	3	4	59	1	0	0	0	0	1	0	0	0	11509	971	34	5	3576	5	PCDH11Y	24	5605460	Missense_Mutation	SNP	G	TCGA-06-0743-01A-01D-1492-08		5605460	53768106	120	3909											
ARID4B	51742	broad.mit.edu	37	chr1	235345495	235345495	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgttttgaagtctttcAtcagagttatttaaaagttt	7	5	3	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr1:235345495A>T	uc001hwq.2	-	20	3237	c.2739T>A	c.(2737-2739)GAT>GAA	p.D913E	ARID4B_uc001hwr.2_Missense_Mutation_p.D827E|ARID4B_uc001hws.3_Missense_Mutation_p.D827E|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.D594E	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	913					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			GAAGTCTTTCATCAGAGTTAT	0.373													T	235345495	T	T	235345495	3	4	60	1	0	0	0	0	1	0	0	0	920	214	8	5	1219	5	ARID4B	1	235345495	Missense_Mutation	SNP	A	TCGA-06-0744-01A-01W-0348-08		235345495	13905126	1	3910											
ZNF638	27332	broad.mit.edu	37	chr2	71651040	71651040	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcagagcagtcttaccagaGgaggcagtggaaggatctca	13	9	3	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr2:71651040G>A	uc002shx.2	+	22	4715	c.4396G>A	c.(4396-4398)GGA>AGA	p.G1466R	ZNF638_uc010yqw.1_Missense_Mutation_p.G1045R|ZNF638_uc002shy.2_Missense_Mutation_p.G1466R|ZNF638_uc002shz.2_Missense_Mutation_p.G1466R|ZNF638_uc002sia.2_Missense_Mutation_p.G1466R|ZNF638_uc002sib.1_Intron|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.G563R|ZNF638_uc002sid.2_Intron	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1466					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TCTTACCAGAGGAGGCAGTGG	0.463													A	71651040	A	A	71651040	3	1	60	1	0	0	0	0	1	0	0	0	18052	1001	35	3	4478	3	ZNF638	2	71651040	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		71651040	171548333	2	3911											
C2orf78	388960	broad.mit.edu	37	chr2	74042973	74042973	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgctacagtcagtaacagCgcttctgtgaacaaggccaa	10	10	2	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr2:74042973C>T	uc002sjr.1	+	3	1744	c.1623C>T	c.(1621-1623)AGC>AGT	p.S541S		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	541										ovary(2)	2						TCAGTAACAGCGCTTCTGTGA	0.502													T	74042973	T	T	74042973	2	4	60	1	0	0	0	0	0	0	0	1	2195	767	27	1		1	C2orf78	2	74042973	Silent	SNP	C	TCGA-06-0744-01A-01W-0348-08	2391933	74042973	169156400	3	3912											
C2orf89	129293	broad.mit.edu	37	chr2	85051153	85051153	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaccgcctccgcttcttccGgaacctctgttcggcctcac	8	18	3	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr2:85051153G>A	uc010ysl.1	-	6	1347	c.1258C>T	c.(1258-1260)CGG>TGG	p.R420W	C2orf89_uc002sou.3_Missense_Mutation_p.R371W	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	420	Extracellular (Potential).					integral to membrane				ovary(1)	1						CGCTTCTTCCGGAACCTCTGT	0.667													A	85051153	A	A	85051153	3	1	60	1	0	0	0	0	1	0	0	0	2203	1115	39	2	267	2	C2orf89	2	85051153	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	11008180	85051153	158148220	4	3913											
RGPD4	285190	broad.mit.edu	37	chr2	108489249	108489249	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagtggatctgaaagcaaaGtggaacctaaaaaatgtgaa	11	4	1	3			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr2:108489249G>A	uc010ywk.1	+	20	4871	c.4789G>A	c.(4789-4791)GTG>ATG	p.V1597M	RGPD4_uc002tdu.2_Missense_Mutation_p.V784M|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1597					intracellular transport		binding			skin(2)	2						TGAAAGCAAAGTGGAACCTAA	0.378													A	108489249	A	A	108489249	3	1	60	1	0	0	0	0	1	0	0	0	13288	1029	36	3	4867	3	RGPD4	2	108489249	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	23438096	108489249	134710124	5	3914											
TTN	7273	broad.mit.edu	37	chr2	179412923	179412923	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcaggtagccagtgatccGgctgcctccatcgtggtcag	13	12	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr2:179412923G>A	uc010zfg.1	-	288	85950	c.85726C>T	c.(85726-85728)CGG>TGG	p.R28576W	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R22271W|TTN_uc010zfi.1_Missense_Mutation_p.R22204W|TTN_uc010zfj.1_Missense_Mutation_p.R22079W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29503							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAGTGATCCGGCTGCCTCCA	0.493													A	179412923	A	A	179412923	3	1	60	1	0	0	0	0	1	0	0	0	16732	1115	39	2	14645	2	TTN	2	179412923	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	70923674	179412923	63786450	6	3915											
SPEG	10290	broad.mit.edu	37	chr2	220309407	220309407	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaggatgacatcagcgatGtgcagggaacccagcgcctg	14	11	1	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr2:220309407G>A	uc010fwg.2	+	2	421	c.421G>A	c.(421-423)GTG>ATG	p.V141M	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Translation_Start_Site|SPEG_uc002vln.1_Translation_Start_Site	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	141					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CATCAGCGATGTGCAGGGAAC	0.622													A	220309407	A	A	220309407	3	1	60	1	0	0	0	0	1	0	0	0	15035	1377	48	3	427	3	SPEG	2	220309407	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	40896484	220309407	22889966	7	3916											
DOCK10	55619	broad.mit.edu	37	chr2	225706579	225706579	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acatatctttctctctttttTggcactcttggaaaaatgca	5	9	4	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr2:225706579T>C	uc010fwz.1	-	23	2842	c.2603A>G	c.(2602-2604)CAA>CGA	p.Q868R	DOCK10_uc002vob.2_Missense_Mutation_p.Q862R	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	868	DHR-1.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTCTCTTTTTTGGCACTCTTG	0.383													C	225706579	C	C	225706579	3	2	60	1	0	0	0	0	1	0	0	0	4685	1812	63	4	4093	4	DOCK10	2	225706579	Missense_Mutation	SNP	T	TCGA-06-0744-01A-01W-0348-08	5397172	225706579	17492794	8	3917											
DGKD	8527	broad.mit.edu	37	chr2	234368926	234368926	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttccctgcacccggagatGctgtccgaggaggaggccac	14	13	0	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr2:234368926G>A	uc002vui.1	+	24	2928	c.2916G>A	c.(2914-2916)ATG>ATA	p.M972I	DGKD_uc002vuj.1_Missense_Mutation_p.M928I|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	972					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	ACCCGGAGATGCTGTCCGAGG	0.617													A	234368926	A	A	234368926	3	1	60	1	0	0	0	0	1	0	0	0	4467	1319	46	3	3034	3	DGKD	2	234368926	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	8662347	234368926	8830447	9	3918											
MSL3L2	151507	broad.mit.edu	37	chr2	234775617	234775617	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgctgggatataaggcacGttcatgctggcatgtggcat	13	8	2	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr2:234775617G>A	uc010znf.1	-	2	463	c.225C>T	c.(223-225)AAC>AAT	p.N75N		NR_024322				SubName: Full=cDNA FLJ52683, highly similar to Male-specific lethal 3-like 1; SubName: Full=cDNA, FLJ79271, highly similar to Male-specific lethal 3-like 1; SubName: Full=HCG1642047;												0						TATAAGGCACGTTCATGCTGG	0.438													A	234775617	A	A	234775617	2	1	60	1	0	0	0	0	0	0	0	1	9880	1136	40	1		1	MSL3L2	2	234775617	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	406691	234775617	8423756	10	3919											
IQCF3	401067	broad.mit.edu	37	chr3	51863721	51863721	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagtagaaagacagaggcGgcagaaggtaggtggggccc	18	7	0	4			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr3:51863721G>A	uc010hlx.1	+	4	400	c.59G>A	c.(58-60)CGG>CAG	p.R20Q	IQCF1_uc003dbq.3_Intron|IQCF3_uc010hlw.1_RNA|IQCF3_uc011bdw.1_RNA	NM_001085479	NP_001078948	P0C7M6	IQCF3_HUMAN	IQ motif containing F3	20										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AGACAGAGGCGGCAGAAGGTA	0.522													A	51863721	A	A	51863721	3	1	60	1	0	0	0	0	1	0	0	0	7809	1116	39	2	65	2	IQCF3	3	51863721	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		51863721	146158709	11	3920											
POU1F1	5449	broad.mit.edu	37	chr3	87325559	87325559	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggcagagttgcagaggcGtcagaattcagaggtataaa	14	5	2	5			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr3:87325559G>A	uc003dqq.1	-	1	179	c.54C>T	c.(52-54)GAC>GAT	p.D18D	POU1F1_uc010hoj.1_Silent_p.D18D	NM_000306	NP_000297	P28069	PIT1_HUMAN	pituitary specific transcription factor 1	18					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|skin(1)	2	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		TTGCAGAGGCGTCAGAATTCA	0.478													A	87325559	A	A	87325559	2	1	60	1	0	0	0	0	0	0	0	1	12269	1136	40	1		1	POU1F1	3	87325559	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	35461838	87325559	110696871	12	3921											
UROC1	131669	broad.mit.edu	37	chr3	126219669	126219669	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gatgtctgatctgaccccagGtccaccaagcactcccccgt	8	17	2	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr3:126219669G>C	uc003eiz.1	-	11	1046	c.1014C>G	c.(1012-1014)GAC>GAG	p.D338E	UROC1_uc010hsi.1_Missense_Mutation_p.D398E	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	338					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		CTGACCCCAGGTCCACCAAGC	0.632													C	126219669	C	C	126219669	3	2	60	1	0	0	0	0	1	0	0	0	17025	1252	44	5	1056	5	UROC1	3	126219669	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	38894110	126219669	71802761	13	3922											
ATR	545	broad.mit.edu	37	chr3	142280158	142280158	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgccttttgggtgatattcCatcactattactgctgaggt	9	9	1	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr3:142280158C>T	uc003eux.3	-	5	1398	c.1276G>A	c.(1276-1278)GGA>AGA	p.G426R		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	426					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						GGTGATATTCCATCACTATTA	0.418								Other_conserved_DNA_damage_response_genes					T	142280158	T	T	142280158	3	4	60	1	0	0	0	0	1	0	0	0	1204	603	21	3	6830	3	ATR	3	142280158	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	16060489	142280158	55742272	14	3923											
MAP3K13	9175	broad.mit.edu	37	chr3	185165672	185165672	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caagatgtcatttgctggcaCggtcgcatggatggcgccag	14	10	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr3:185165672C>A	uc010hyf.2	+	6	1213	c.947C>A	c.(946-948)ACG>AAG	p.T316K	MAP3K13_uc011brt.1_Missense_Mutation_p.T109K|MAP3K13_uc003fph.3_Missense_Mutation_p.T84K|MAP3K13_uc011bru.1_Missense_Mutation_p.T172K|MAP3K13_uc003fpi.2_Missense_Mutation_p.T316K|MAP3K13_uc010hyg.2_Missense_Mutation_p.T6K	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	316	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TTTGCTGGCACGGTCGCATGG	0.443													A	185165672	A	A	185165672	3	1	60	1	0	0	0	0	1	0	0	0	9247	536	19	5	961	5	MAP3K13	3	185165672	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	42885514	185165672	12856758	15	3924											
KNG1	3827	broad.mit.edu	37	chr3	186457116	186457116	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacttctgttttcatggataGcaaagcctagattgcaacgc	9	9	2	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr3:186457116G>A	uc011bsa.1	+	9	1251	c.1039_splice	c.e9-1	p.Q347_splice	KNG1_uc003fqr.2_Splice_Site_p.Q347_splice	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1						blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	TTCATGGATAGCAAAGCCTAG	0.373													A	186457116	A	A	186457116	5	1	60	1	0	0	0	0	0	0	1	0	8427	985	34	3	1072	3	KNG1	3	186457116	Splice_Site	SNP	G	TCGA-06-0744-01A-01W-0348-08	1291444	186457116	11565314	16	3925											
TP63	8626	broad.mit.edu	37	chr3	189582120	189582120	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcagggagctgttatccgcGccatgcctgtctacaaaaaa	9	12	2	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr3:189582120G>A	uc003fry.2	+	5	768	c.679G>A	c.(679-681)GCC>ACC	p.A227T	TP63_uc003frx.2_Missense_Mutation_p.A227T|TP63_uc003frz.2_Missense_Mutation_p.A227T|TP63_uc010hzc.1_Missense_Mutation_p.A227T|TP63_uc003fsa.2_Missense_Mutation_p.A133T|TP63_uc003fsb.2_Missense_Mutation_p.A133T|TP63_uc003fsc.2_Missense_Mutation_p.A133T|TP63_uc003fsd.2_Missense_Mutation_p.A133T|TP63_uc010hzd.1_Missense_Mutation_p.A48T|TP63_uc003fse.1_Missense_Mutation_p.A108T	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	227					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGTTATCCGCGCCATGCCTGT	0.517									Hay-Wells_syndrome	HNSCC(45;0.13)			A	189582120	A	A	189582120	3	1	60	1	0	0	0	0	1	0	0	0	16389	1087	38	1	743	1	TP63	3	189582120	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	3125004	189582120	8440310	17	3926											
JAKMIP1	152789	broad.mit.edu	37	chr4	6107274	6107274	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcgcctggtaggcggcacGcaggtcggctgccttggtct	17	12	1	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr4:6107274G>A	uc003giu.3	-	3	826	c.550C>T	c.(550-552)CGT>TGT	p.R184C	JAKMIP1_uc010idb.1_Missense_Mutation_p.R184C|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.R184C|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.R184C|JAKMIP1_uc010ide.2_Missense_Mutation_p.R184C	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	184	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TAGGCGGCACGCAGGTCGGCT	0.682													A	6107274	A	A	6107274	3	1	60	1	0	0	0	0	1	0	0	0	7940	1087	38	1	2096	1	JAKMIP1	4	6107274	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		6107274	185047002	18	3927											
CENPE	1062	broad.mit.edu	37	chr4	104079809	104079809	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aatatcacttttgagttggtCcctctcaatttgcaagcttt	6	9	2	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr4:104079809C>T	uc003hxb.1	-	23	2926	c.2836G>A	c.(2836-2838)GAC>AAC	p.D946N	CENPE_uc003hxc.1_Missense_Mutation_p.D921N	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	946	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTGAGTTGGTCCCTCTCAATT	0.333													T	104079809	T	T	104079809	3	4	60	1	0	0	0	0	1	0	0	0	3230	855	30	3	5377	3	CENPE	4	104079809	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	97972535	104079809	87074467	19	3928											
EXOSC9	5393	broad.mit.edu	37	chr4	122735086	122735086	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agagggagtagaaaactcctGgggtgatcttgaagactctg	14	6	2	5			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr4:122735086G>C	uc003iea.2	+	10	1148	c.1040G>C	c.(1039-1041)TGG>TCG	p.W347S	EXOSC9_uc003idz.2_Missense_Mutation_p.W347S|EXOSC9_uc003ieb.2_Missense_Mutation_p.W331S|EXOSC9_uc010inp.1_RNA	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	347					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						GAAAACTCCTGGGGTGATCTT	0.413													C	122735086	C	C	122735086	3	2	60	1	0	0	0	0	1	0	0	0	5321	1357	47	5	1078	5	EXOSC9	4	122735086	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	18655277	122735086	68419190	20	3929											
GYPA	2993	broad.mit.edu	37	chr4	145038021	145038021	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctcacctttatcagtcggcGaataccgtaagaaattaaga	7	9	2	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr4:145038021G>A	uc003ijo.3	-	5	459	c.343C>T	c.(343-345)CGC>TGC	p.R115C	GYPA_uc003ijn.2_Intron|GYPA_uc011cia.1_RNA|GYPA_uc011cib.1_Missense_Mutation_p.R82C|GYPA_uc003ijp.3_Missense_Mutation_p.R83C|GYPA_uc010ioq.2_Missense_Mutation_p.R102C|GYPA_uc010ior.2_Missense_Mutation_p.R50C|GYPA_uc010ios.1_RNA	NM_002099	NP_002090	P02724	GLPA_HUMAN	glycophorin A precursor	115	Cytoplasmic.				interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)	2	all_hematologic(180;0.15)					ATCAGTCGGCGAATACCGTAA	0.368													A	145038021	A	A	145038021	3	1	60	1	0	0	0	0	1	0	0	0	6908	1058	37	2	121	2	GYPA	4	145038021	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	22302935	145038021	46116255	21	3930											
ADAM29	11086	broad.mit.edu	37	chr4	175897195	175897195	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgcaaaatgaaataacatgCcgaatggaatttgaagaaat	8	4	0	3			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr4:175897195C>A	uc003iuc.2	+	5	1189	c.519C>A	c.(517-519)TGC>TGA	p.C173*	ADAM29_uc003iud.2_Nonsense_Mutation_p.C173*|ADAM29_uc010irr.2_Nonsense_Mutation_p.C173*|ADAM29_uc011cki.1_Nonsense_Mutation_p.C173*	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	173					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AAATAACATGCCGAATGGAAT	0.368													A	175897195	A	A	175897195	4	1	60	1	0	0	0	0	0	1	0	0	247	747	26	5	521	5	ADAM29	4	175897195	Nonsense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	30859174	175897195	15257081	22	3931											
CCDC110	256309	broad.mit.edu	37	chr4	186381243	186381243	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcagagttaatgtgtcctcGgaatgtatctgggatggaac	12	7	2	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr4:186381243G>A	uc003ixu.3	-	6	574	c.498C>T	c.(496-498)TCC>TCT	p.S166S	CCDC110_uc003ixv.3_Silent_p.S129S|CCDC110_uc011ckt.1_Silent_p.S166S	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	166						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		ATGTGTCCTCGGAATGTATCT	0.348													A	186381243	A	A	186381243	2	1	60	1	0	0	0	0	0	0	0	1	2747	1103	39	2		2	CCDC110	4	186381243	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	10484048	186381243	4773033	23	3932											
ADCY2	108	broad.mit.edu	37	chr5	7743842	7743842	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctggccttcatcctcttcGtctgctttgctggacagctt	9	13	3	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:7743842G>A	uc003jdz.1	+	15	2000	c.1933G>A	c.(1933-1935)GTC>ATC	p.V645I	ADCY2_uc011cmo.1_Missense_Mutation_p.V465I	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	645	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CATCCTCTTCGTCTGCTTTGC	0.478													A	7743842	A	A	7743842	3	1	60	1	0	0	0	0	1	0	0	0	294	1145	40	1	1991	1	ADCY2	5	7743842	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		7743842	173171418	24	3933											
PDZD2	23037	broad.mit.edu	37	chr5	31995769	31995769	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggaggccgaggatcaaagCgctcacctcacgctatcgtt	12	12	3	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:31995769C>T	uc003jhl.2	+	4	1454	c.1066C>T	c.(1066-1068)CGC>TGC	p.R356C	PDZD2_uc003jhm.2_Missense_Mutation_p.R356C|PDZD2_uc011cnx.1_Missense_Mutation_p.R182C	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	356	PDZ 2.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGGATCAAAGCGCTCACCTCA	0.423													T	31995769	T	T	31995769	3	4	60	1	0	0	0	0	1	0	0	0	11701	768	27	1	1076	1	PDZD2	5	31995769	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	24251927	31995769	148919491	25	3934											
ADAMTS12	81792	broad.mit.edu	37	chr5	33576992	33576992	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggactagggctgctgattgCtggagtgcttgtgctcatag	15	7	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:33576992C>T	uc003jia.1	-	19	3302	c.3139G>A	c.(3139-3141)GCA>ACA	p.A1047T	ADAMTS12_uc010iuq.1_Missense_Mutation_p.A962T	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1047	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CTGCTGATTGCTGGAGTGCTT	0.552										HNSCC(64;0.19)			T	33576992	T	T	33576992	3	4	60	1	0	0	0	0	1	0	0	0	257	797	28	3	1669	3	ADAMTS12	5	33576992	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	1581223	33576992	147338268	26	3935											
ADAMTS12	81792	broad.mit.edu	37	chr5	33684033	33684033	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tattcaatcatctttgtgtcGgccaccaccagtgtctccac	6	14	4	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:33684033G>A	uc003jia.1	-	4	925	c.762C>T	c.(760-762)GCC>GCT	p.A254A	ADAMTS12_uc010iuq.1_Silent_p.A254A	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	254	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCTTTGTGTCGGCCACCACCA	0.547										HNSCC(64;0.19)			A	33684033	A	A	33684033	2	1	60	1	0	0	0	0	0	0	0	1	257	1103	39	2		2	ADAMTS12	5	33684033	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	107041	33684033	147231227	27	3936											
OSMR	9180	broad.mit.edu	37	chr5	38924670	38924670	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaggcgaggcagtgccacCcacgatttgaaaaggcagtt	12	11	0	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:38924670C>T	uc003jln.1	+	14	2384	c.2017C>T	c.(2017-2019)CCA>TCA	p.P673S	OSMR_uc011cpj.1_5'UTR	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	673	Fibronectin type-III 4.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					GCAGTGCCACCCACGATTTGA	0.358													T	38924670	T	T	38924670	3	4	60	1	0	0	0	0	1	0	0	0	11292	623	22	3	2105	3	OSMR	5	38924670	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	5240637	38924670	141990590	28	3937											
CMYA5	202333	broad.mit.edu	37	chr5	79035031	79035031	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgctgaacaaaaagagttGggcagcgagaggaaagaaga	14	6	0	5			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:79035031G>A	uc003kgc.2	+	2	10515	c.10443G>A	c.(10441-10443)TTG>TTA	p.L3481L		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3481						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAAAAGAGTTGGGCAGCGAGA	0.403													A	79035031	A	A	79035031	2	1	60	1	0	0	0	0	0	0	0	1	3590	1339	47	3		3	CMYA5	5	79035031	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	40110361	79035031	101880229	29	3938											
CTNNA1	1495	broad.mit.edu	37	chr5	138253458	138253458	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgctgcactggctttagcaGcaaaaccacagagtaaactg	9	10	0	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:138253458G>A	uc003ldh.2	+	11	1512	c.1417G>A	c.(1417-1419)GCA>ACA	p.A473T	CTNNA1_uc011cyx.1_Missense_Mutation_p.A370T|CTNNA1_uc011cyy.1_Missense_Mutation_p.A350T|CTNNA1_uc003ldi.2_Missense_Mutation_p.A171T|CTNNA1_uc003ldj.2_Missense_Mutation_p.A473T|CTNNA1_uc003ldl.2_Missense_Mutation_p.A103T	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	473				A -> P (in Ref. 3; AAA86430/AAA18949).	adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GGCTTTAGCAGCAAAACCACA	0.388													A	138253458	A	A	138253458	3	1	60	1	0	0	0	0	1	0	0	0	4012	971	34	3	1455	3	CTNNA1	5	138253458	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	59218427	138253458	42661802	30	3939											
PCDHA8	56140	broad.mit.edu	37	chr5	140222780	140222780	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcgcatcccgttccgcgtggGgctgtacacgggcgagatca	14	13	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:140222780G>T	uc003lhs.2	+	1	1874	c.1874G>T	c.(1873-1875)GGG>GTG	p.G625V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.G625V	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	625	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCGCGTGGGGCTGTACACG	0.652													T	140222780	T	T	140222780	3	4	60	1	0	0	0	0	1	0	0	0	11530	1232	43	5	1876	5	PCDHA8	5	140222780	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	1969322	140222780	40692480	31	3940											
PCDHB7	56129	broad.mit.edu	37	chr5	140554382	140554382	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcctccgcgctcggccaccGccacgctgcacgtgctcctg	11	20	0	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:140554382G>A	uc003lit.2	+	1	2140	c.1966G>A	c.(1966-1968)GCC>ACC	p.A656T		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	656	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCGGCCACCGCCACGCTGCA	0.706													A	140554382	A	A	140554382	3	1	60	1	0	0	0	0	1	0	0	0	11547	1087	38	1	1968	1	PCDHB7	5	140554382	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	331602	140554382	40360878	32	3941											
NMUR2	56923	broad.mit.edu	37	chr5	151771915	151771915	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attctgtcaggaagatgttcCgctgggcaggtggcaactgt	14	8	2	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr5:151771915C>T	uc003luv.2	-	4	1251	c.1085G>A	c.(1084-1086)CGG>CAG	p.R362Q		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	362	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GAAGATGTTCCGCTGGGCAGG	0.532													T	151771915	T	T	151771915	3	4	60	1	0	0	0	0	1	0	0	0	10507	652	23	2	166	2	NMUR2	5	151771915	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	11217533	151771915	29143345	33	3942											
TRIM40	135644	broad.mit.edu	37	chr6	30114887	30114887	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcacatgccagcagaagcGgccagaatccttgacatctc	10	13	1	3			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr6:30114887G>A	uc003npk.2	+	4	953	c.567G>A	c.(565-567)GCG>GCA	p.A189A	TRIM40_uc003npm.2_Silent_p.A160A	NM_138700	NP_619645	Q6P9F5	TRI40_HUMAN	tripartite motif-containing 40	189						intracellular	zinc ion binding			ovary(1)	1						CAGCAGAAGCGGCCAGAATCC	0.597													A	30114887	A	A	30114887	2	1	60	1	0	0	0	0	0	0	0	1	16512	1103	39	2		2	TRIM40	6	30114887	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08		30114887	141000180	34	3943											
TRIM10	10107	broad.mit.edu	37	chr6	30127012	30127012	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttagacatttaagacacttaTggatttgttcctggggagaa	10	5	0	3			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr6:30127012T>C	uc003npo.3	-	2	516	c.440A>G	c.(439-441)CAT>CGT	p.H147R	TRIM10_uc003npn.2_Missense_Mutation_p.H147R	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	147						cytoplasm	zinc ion binding				0						AAGACACTTATGGATTTGTTC	0.403													C	30127012	C	C	30127012	3	2	60	1	0	0	0	0	1	0	0	0	16483	1464	51	4	1117	4	TRIM10	6	30127012	Missense_Mutation	SNP	T	TCGA-06-0744-01A-01W-0348-08	12125	30127012	140988055	35	3944											
GPR115	221393	broad.mit.edu	37	chr6	47681719	47681719	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attcagacaaaagggtttcaCatcaaccataatacctcaga	5	10	4	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr6:47681719C>A	uc003oza.1	+	6	996	c.738C>A	c.(736-738)CAC>CAA	p.H246Q	GPR115_uc003oyz.1_Missense_Mutation_p.H303Q|GPR115_uc003ozb.1_Missense_Mutation_p.H244Q	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	246	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						AAGGGTTTCACATCAACCATA	0.393													A	47681719	A	A	47681719	3	1	60	1	0	0	0	0	1	0	0	0	6632	477	17	5	756	5	GPR115	6	47681719	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	17554707	47681719	123433348	36	3945											
DOPEY1	23033	broad.mit.edu	37	chr6	83830474	83830474	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgcaggatctaaagccttttCgcattttaatcagtttactg	7	8	2	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr6:83830474C>T	uc003pjs.1	+	10	1323	c.1063C>T	c.(1063-1065)CGC>TGC	p.R355C	DOPEY1_uc011dyy.1_Missense_Mutation_p.R346C|DOPEY1_uc010kbl.1_Missense_Mutation_p.R346C	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	355					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAAGCCTTTTCGCATTTTAAT	0.368													T	83830474	T	T	83830474	3	4	60	1	0	0	0	0	1	0	0	0	4707	884	31	2	1093	2	DOPEY1	6	83830474	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	36148755	83830474	87284593	37	3946											
AIM1	202	broad.mit.edu	37	chr6	106978130	106978130	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcctactttgatgatactgAagaaatgcagggatttggtg	11	5	0	4			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr6:106978130A>C	uc003prh.2	+	6	3921	c.3434A>C	c.(3433-3435)GAA>GCA	p.E1145A		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1145	Beta/gamma crystallin 'Greek key' 3.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		GATGATACTGAAGAAATGCAG	0.328													C	106978130	C	C	106978130	3	2	60	1	0	0	0	0	1	0	0	0	430	246	9	5	3456	5	AIM1	6	106978130	Missense_Mutation	SNP	A	TCGA-06-0744-01A-01W-0348-08	23147656	106978130	64136937	38	3947											
ELMO1	9844	broad.mit.edu	37	chr7	37253052	37253052	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgttgatggcccgctgggctCggatgacatgctagggagat	16	8	0	3			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr7:37253052C>T	uc003tfk.1	-	12	1149	c.842G>A	c.(841-843)CGA>CAA	p.R281Q	ELMO1_uc011kbc.1_Missense_Mutation_p.R185Q|ELMO1_uc010kxg.1_Missense_Mutation_p.R281Q	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	281					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						CCGCTGGGCTCGGATGACATG	0.433													T	37253052	T	T	37253052	3	4	60	1	0	0	0	0	1	0	0	0	5065	884	31	2	1385	2	ELMO1	7	37253052	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08		37253052	121885611	39	3948											
ELMO1	9844	broad.mit.edu	37	chr7	37298915	37298915	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccagcttggcatccatactcGaggactggattcgttcatgg	11	11	1	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr7:37298915G>A	uc003tfk.1	-	6	591	c.284C>T	c.(283-285)TCG>TTG	p.S95L	ELMO1_uc011kbc.1_5'UTR|ELMO1_uc010kxg.1_Missense_Mutation_p.S95L	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	95					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						ATCCATACTCGAGGACTGGAT	0.522													A	37298915	A	A	37298915	3	1	60	1	0	0	0	0	1	0	0	0	5065	1059	37	2	1967	2	ELMO1	7	37298915	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	45863	37298915	121839748	40	3949											
WBSCR17	64409	broad.mit.edu	37	chr7	70881029	70881029	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actggcttctttgatgcccaCgtggaattcaccgctggctg	11	12	2	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr7:70881029C>T	uc003tvy.2	+	4	744	c.744C>T	c.(742-744)CAC>CAT	p.H248H	WBSCR17_uc003tvz.2_Translation_Start_Site	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	248	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TTGATGCCCACGTGGAATTCA	0.567													T	70881029	T	T	70881029	2	4	60	1	0	0	0	0	0	0	0	1	17261	535	19	1		1	WBSCR17	7	70881029	Silent	SNP	C	TCGA-06-0744-01A-01W-0348-08	33582114	70881029	88257634	41	3950											
NSUN5	55695	broad.mit.edu	37	chr7	72721634	72721634	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcattccggctcacaccccGatgaaccttgagccgagcca	8	17	2	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr7:72721634G>A	uc003txw.2	-	3	373	c.337C>T	c.(337-339)CGG>TGG	p.R113W	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Missense_Mutation_p.R113W|NSUN5_uc003txx.2_Missense_Mutation_p.R75W|NSUN5_uc011kev.1_Missense_Mutation_p.R113W	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	113							methyltransferase activity				0		Lung NSC(55;0.163)				CTCACACCCCGATGAACCTTG	0.637													A	72721634	A	A	72721634	3	1	60	1	0	0	0	0	1	0	0	0	10681	1057	37	2	1116	2	NSUN5	7	72721634	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	1840605	72721634	86417029	42	3951											
SAMD9	54809	broad.mit.edu	37	chr7	92734204	92734204	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gtatgaattatctaacaaatCttgatttcctgtcaataatt	4	6	3	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr7:92734204C>A	uc003umf.2	-	3	1463	c.1207G>T	c.(1207-1209)GAT>TAT	p.D403Y	SAMD9_uc003umg.2_Missense_Mutation_p.D403Y	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	403						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TCTAACAAATCTTGATTTCCT	0.323													A	92734204	A	A	92734204	3	1	60	1	0	0	0	0	1	0	0	0	13826	913	32	5	3566	5	SAMD9	7	92734204	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	20012570	92734204	66404459	43	3952											
PON1	5444	broad.mit.edu	37	chr7	94931534	94931534	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tacctctgatgcaggaggatTctctgagtcatagaagaaga	11	7	3	5			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr7:94931534T>A	uc003uns.2	-	8	989	c.892A>T	c.(892-894)AAT>TAT	p.N298Y	PON1_uc011kih.1_Missense_Mutation_p.N298Y	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	298					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GCAGGAGGATTCTCTGAGTCA	0.398													A	94931534	A	A	94931534	3	1	60	1	0	0	0	0	1	0	0	0	12248	1783	62	5	183	5	PON1	7	94931534	Missense_Mutation	SNP	T	TCGA-06-0744-01A-01W-0348-08	2197330	94931534	64207129	44	3953											
MUC17	140453	broad.mit.edu	37	chr7	100675948	100675948	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agcaccacttcaacaattccTgttgactccaaaacttttgt	4	12	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr7:100675948T>C	uc003uxp.1	+	3	1304	c.1251T>C	c.(1249-1251)CCT>CCC	p.P417P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	417	Extracellular (Potential).|59 X approximate tandem repeats.|4.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAACAATTCCTGTTGACTCCA	0.458													C	100675948	C	C	100675948	2	2	60	1	0	0	0	0	0	0	0	1	9974	1567	55	4		4	MUC17	7	100675948	Silent	SNP	T	TCGA-06-0744-01A-01W-0348-08	5744414	100675948	58462715	45	3954											
ARHGEF35	445328	broad.mit.edu	37	chr7	143884194	143884194	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcccgggaatctgagtcacgAgatatgaggcacctggaaac	12	10	2	3			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr7:143884194A>T	uc003wdz.1	-	2	1401	c.1283T>A	c.(1282-1284)CTC>CAC	p.L428H		NM_001003702	NP_001003702	A5YM69	ARG35_HUMAN	Rho guanine nucleotide exchange factor (GEF)	428											0						CTGAGTCACGAGATATGAGGC	0.572													T	143884194	T	T	143884194	3	4	60	1	0	0	0	0	1	0	0	0	905	304	11	5	175	5	ARHGEF35	7	143884194	Missense_Mutation	SNP	A	TCGA-06-0744-01A-01W-0348-08	43208246	143884194	15254469	46	3955											
GALNT11	63917	broad.mit.edu	37	chr7	151805176	151805176	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagtgaatgtgatgtggctgCagcccttgctggccgccatc	13	11	0	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr7:151805176C>G	uc010lqg.1	+	6	996	c.766C>G	c.(766-768)CAG>GAG	p.Q256E	GALNT11_uc011kvm.1_Missense_Mutation_p.Q175E|GALNT11_uc003wku.2_Missense_Mutation_p.Q256E|GALNT11_uc011kvn.1_RNA|GALNT11_uc003wkw.1_Missense_Mutation_p.Q4E	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	256	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		GATGTGGCTGCAGCCCTTGCT	0.582													G	151805176	G	G	151805176	3	3	60	1	0	0	0	0	1	0	0	0	6209	711	25	5	784	5	GALNT11	7	151805176	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	7920982	151805176	7333487	47	3956											
DOCK5	80005	broad.mit.edu	37	chr8	25167952	25167952	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatccttgaagctcttgcccGgtgacctcacccaggttcag	9	14	3	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr8:25167952G>A	uc003xeg.2	+	13	1359	c.1222G>A	c.(1222-1224)GGT>AGT	p.G408S	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.G122S|DOCK5_uc003xei.2_5'UTR	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	408						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GCTCTTGCCCGGTGACCTCAC	0.408													A	25167952	A	A	25167952	3	1	60	1	0	0	0	0	1	0	0	0	4690	1116	39	2	1272	2	DOCK5	8	25167952	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		25167952	121196070	48	3957											
RAB11FIP1	80223	broad.mit.edu	37	chr8	37730005	37730005	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcccatgggaagagggggcGccacttcttcagctgcatcc	12	14	2	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr8:37730005G>A	uc003xkm.1	-	4	2359	c.2315C>T	c.(2314-2316)GCG>GTG	p.A772V	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.A101V|RAB11FIP1_uc003xko.1_Missense_Mutation_p.A101V|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	772					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			AAGAGGGGGCGCCACTTCTTC	0.567													A	37730005	A	A	37730005	3	1	60	1	0	0	0	0	1	0	0	0	12893	1087	38	1	1548	1	RAB11FIP1	8	37730005	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	12562053	37730005	108634017	49	3958											
PGCP	10404	broad.mit.edu	37	chr8	97797551	97797551	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcagcattgggactccTccagaaggtattgtttgtct	12	9	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr8:97797551T>A	uc003yhw.2	+	2	592	c.426T>A	c.(424-426)CCT>CCA	p.P142P	PGCP_uc010mbe.2_Silent_p.P142P	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	142					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					TTGGGACTCCTCCAGAAGGTA	0.398													A	97797551	A	A	97797551	2	1	60	1	0	0	0	0	0	0	0	1	11786	1538	54	5		5	PGCP	8	97797551	Silent	SNP	T	TCGA-06-0744-01A-01W-0348-08	60067546	97797551	48566471	50	3959											
RIMS2	9699	broad.mit.edu	37	chr8	105001597	105001597	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacattataatacaattagcCgaatggacagacatcgtgtc	8	8	0	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr8:105001597C>T	uc003yls.2	+	15	2567	c.2326C>T	c.(2326-2328)CGA>TGA	p.R776*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.R998*|RIMS2_uc003ylw.2_Nonsense_Mutation_p.R790*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.R790*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.R837*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1060					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TACAATTAGCCGAATGGACAG	0.368										HNSCC(12;0.0054)			T	105001597	T	T	105001597	4	4	60	1	0	0	0	0	0	1	0	0	13368	644	23	2	3184	2	RIMS2	8	105001597	Nonsense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	7204046	105001597	41362425	51	3960											
ENPP2	5168	broad.mit.edu	37	chr8	120569920	120569920	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttctacccattttgattcGtcctctgagctctgcaatgg	7	12	4	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr8:120569920G>A	uc003yot.1	-	25	2519	c.2433C>T	c.(2431-2433)GAC>GAT	p.D811D	ENPP2_uc011lic.1_Silent_p.D349D|ENPP2_uc003yor.1_Silent_p.D446D|ENPP2_uc003yos.1_Silent_p.D863D|ENPP2_uc010mdd.1_Silent_p.D836D	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	811					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATTTTGATTCGTCCTCTGAGC	0.453													A	120569920	A	A	120569920	2	1	60	1	0	0	0	0	0	0	0	1	5130	1136	40	1		1	ENPP2	8	120569920	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	15568323	120569920	25794102	52	3961											
GLI4	2738	broad.mit.edu	37	chr8	144358513	144358513	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcaagcgcttccgcggctggTcgggcttcatccagcaccac	12	16	1	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr8:144358513T>G	uc003yxx.2	+	4	755	c.670T>G	c.(670-672)TCG>GCG	p.S224A	ZFP41_uc003yxv.2_RNA	NM_138465	NP_612474	P10075	GLI4_HUMAN	GLI-Kruppel family member GLI4	224	C2H2-type 2.					nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CCGCGGCTGGTCGGGCTTCAT	0.652													G	144358513	G	G	144358513	3	3	60	1	0	0	0	0	1	0	0	0	6440	1667	58	5	680	5	GLI4	8	144358513	Missense_Mutation	SNP	T	TCGA-06-0744-01A-01W-0348-08	23788593	144358513	2005509	53	3962											
EPPK1	83481	broad.mit.edu	37	chr8	144940380	144940380	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgtgcacggggtcgatgaCgccgcccgtggcgatctggg	18	12	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr8:144940380C>T	uc003zaa.1	-	2	15065	c.15052G>A	c.(15052-15054)GTC>ATC	p.V5018I		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5018	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGTCGATGACGCCGCCCGTG	0.697													T	144940380	T	T	144940380	3	4	60	1	0	0	0	0	1	0	0	0	5190	536	19	1	224	1	EPPK1	8	144940380	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	581867	144940380	1423642	54	3963											
TAF1L	138474	broad.mit.edu	37	chr9	32630560	32630560	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctcgagacgtactgagggatGtgttggtatcatacatatca	11	7	2	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr9:32630560G>C	uc003zrg.1	-	1	5108	c.5018C>G	c.(5017-5019)ACA>AGA	p.T1673R	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1673					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		ACTGAGGGATGTGTTGGTATC	0.473													C	32630560	C	C	32630560	3	2	60	1	0	0	0	0	1	0	0	0	15520	1377	48	5	466	5	TAF1L	9	32630560	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		32630560	108582871	55	3964											
FAM75C1	441452	broad.mit.edu	37	chr9	90536517	90536517	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagcccttgaggagtgactcAggaagtgatttattaagacg	12	6	1	4			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr9:90536517A>G	uc010mqi.2	+	4	1724	c.1695A>G	c.(1693-1695)TCA>TCG	p.S565S	FAM75C1_uc004apq.3_Silent_p.S548S	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GGAGTGACTCAGGAAGTGATT	0.507													G	90536517	G	G	90536517	2	3	60	1	0	0	0	0	0	0	0	1	5623	175	7	4		4	FAM75C1	9	90536517	Silent	SNP	A	TCGA-06-0744-01A-01W-0348-08	57905957	90536517	50676914	56	3965											
C9orf156	51531	broad.mit.edu	37	chr9	100672419	100672419	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgccctgcttccttgcaagaCtgctgctccttccactcttt	6	16	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr9:100672419C>A	uc004axv.1	-	4	966	c.889G>T	c.(889-891)GTC>TTC	p.V297F	C9orf156_uc004axw.1_Missense_Mutation_p.V194F|C9orf156_uc004axx.1_Missense_Mutation_p.V151F|C9orf156_uc010msq.1_Missense_Mutation_p.V194F	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	297					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				CCTTGCAAGACTGCTGCTCCT	0.562													A	100672419	A	A	100672419	3	1	60	1	0	0	0	0	1	0	0	0	2465	565	20	5	444	5	C9orf156	9	100672419	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	10135902	100672419	40541012	57	3966											
ANKS6	203286	broad.mit.edu	37	chr9	101530447	101530447	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctggccccacagggcttgaCcgatggctgggtttctgctc	14	13	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr9:101530447C>T	uc004ayu.2	-	11	2079	c.2058G>A	c.(2056-2058)CGG>CGA	p.R686R	ANKS6_uc004ayt.2_Silent_p.R385R|ANKS6_uc004ayv.1_Silent_p.R148R|ANKS6_uc004ayw.1_Silent_p.R268R|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	686	Ser-rich.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				CAGGGCTTGACCGATGGCTGG	0.577													T	101530447	T	T	101530447	2	4	60	1	0	0	0	0	0	0	0	1	692	494	18	3		3	ANKS6	9	101530447	Silent	SNP	C	TCGA-06-0744-01A-01W-0348-08	858028	101530447	39682984	58	3967											
GRIN3A	116443	broad.mit.edu	37	chr9	104499635	104499635	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggactaagctgaccaagtcGagctccatcatttcgccctg	9	13	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr9:104499635G>A	uc004bbp.1	-	1	1228	c.627C>T	c.(625-627)CTC>CTT	p.L209L	GRIN3A_uc004bbq.1_Silent_p.L209L	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	209	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TGACCAAGTCGAGCTCCATCA	0.597													A	104499635	A	A	104499635	2	1	60	1	0	0	0	0	0	0	0	1	6783	1045	37	2		2	GRIN3A	9	104499635	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	2969188	104499635	36713796	59	3968											
OR13C5	138799	broad.mit.edu	37	chr9	107361108	107361108	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggtcacaagcaggatgaacTcattgcctgagatgtcagca	11	9	3	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr9:107361108T>A	uc011lvp.1	-	1	587	c.587A>T	c.(586-588)GAG>GTG	p.E196V		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CAGGATGAACTCATTGCCTGA	0.383													A	107361108	A	A	107361108	3	1	60	1	0	0	0	0	1	0	0	0	10937	1551	54	5	371	5	OR13C5	9	107361108	Missense_Mutation	SNP	T	TCGA-06-0744-01A-01W-0348-08	2861473	107361108	33852323	60	3969											
KCNT1	57582	broad.mit.edu	37	chr9	138671275	138671275	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcgcttcatgcagttccgcGccaaggacagctactctctg	10	14	2	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr9:138671275G>A	uc011mdq.1	+	24	2874	c.2800G>A	c.(2800-2802)GCC>ACC	p.A934T	KCNT1_uc011mdr.1_Missense_Mutation_p.A761T|KCNT1_uc010nbf.2_Missense_Mutation_p.A889T|KCNT1_uc004cgo.1_Missense_Mutation_p.A683T	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	934						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GCAGTTCCGCGCCAAGGACAG	0.622													A	138671275	A	A	138671275	3	1	60	1	0	0	0	0	1	0	0	0	8091	1087	38	1	2894	1	KCNT1	9	138671275	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	31310167	138671275	2542156	61	3970											
RIC8A	60626	broad.mit.edu	37	chr11	209578	209578	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atgctgacatctctgtctctGaggggtccgtcccagagtcc	11	13	2	3			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:209578G>A	uc001log.2	+	3	629	c.304G>A	c.(304-306)GAG>AAG	p.E102K	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Missense_Mutation_p.E102K|RIC8A_uc001loh.2_Missense_Mutation_p.E95K	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	102						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTCTGTCTCTGAGGGGTCCGT	0.617													A	209578	A	A	209578	3	1	60	1	0	0	0	0	1	0	0	0	13355	1291	45	3	314	3	RIC8A	11	209578	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		209578	134796938	62	3971											
GALNTL4	374378	broad.mit.edu	37	chr11	11398782	11398782	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggccttggggggatttagGtagcggcaccacagctccca	14	12	0	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:11398782G>A	uc001mjo.2	-	5	1345	c.924C>T	c.(922-924)TAC>TAT	p.Y308Y		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	308	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		GGGGATTTAGGTAGCGGCACC	0.532													A	11398782	A	A	11398782	2	1	60	1	0	0	0	0	0	0	0	1	6223	1256	44	3		3	GALNTL4	11	11398782	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	11189204	11398782	123607734	63	3972											
C11orf41	25758	broad.mit.edu	37	chr11	33564672	33564672	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcctccccatctcctgtgccAgaaatgcccactcttccagc	6	19	2	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:33564672A>G	uc001mup.3	+	1	796	c.672A>G	c.(670-672)CCA>CCG	p.P224P	C11orf41_uc001mun.1_Silent_p.P224P	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	224						integral to membrane				ovary(2)	2						CTCCTGTGCCAGAAATGCCCA	0.537											OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	33564672	G	G	33564672	2	3	60	1	0	0	0	0	0	0	0	1	1640	175	7	4		4	C11orf41	11	33564672	Silent	SNP	A	TCGA-06-0744-01A-01W-0348-08	22165890	33564672	101441844	64	3973											
OR4A47	403253	broad.mit.edu	37	chr11	48510526	48510526	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcaccaatgtacttctttcTtgctggcttatcatttatag	5	10	4	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:48510526T>C	uc010rhx.1	+	1	182	c.182T>C	c.(181-183)CTT>CCT	p.L61P		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TACTTCTTTCTTGCTGGCTTA	0.408													C	48510526	C	C	48510526	3	2	60	1	0	0	0	0	1	0	0	0	11042	1609	56	4	184	4	OR4A47	11	48510526	Missense_Mutation	SNP	T	TCGA-06-0744-01A-01W-0348-08	14945854	48510526	86495990	65	3974											
OR5I1	10798	broad.mit.edu	37	chr11	55703856	55703856	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aactcagtgaccaacgtgtaGtttctatctgtaaattccat	6	9	3	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:55703856G>C	uc010ris.1	-	1	21	c.21C>G	c.(19-21)AAC>AAG	p.N7K		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCAACGTGTAGTTTCTATCTG	0.323													C	55703856	C	C	55703856	3	2	60	1	0	0	0	0	1	0	0	0	11164	1020	36	5	926	5	OR5I1	11	55703856	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	7193330	55703856	79302660	66	3975											
SLC22A8	9376	broad.mit.edu	37	chr11	62767306	62767306	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaggtcaggatgggcctgCggccaaacctgtagctcgaa	14	11	1	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:62767306C>T	uc001nwo.2	-	4	582	c.446G>A	c.(445-447)CGC>CAC	p.R149H	SLC22A8_uc001nwn.1_5'Flank|SLC22A8_uc001nwp.2_Missense_Mutation_p.R149H|SLC22A8_uc009yom.2_Missense_Mutation_p.R26H|SLC22A8_uc010rmm.1_Missense_Mutation_p.R58H|SLC22A8_uc009yon.2_Missense_Mutation_p.R149H	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	149	Cytoplasmic (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						GATGGGCCTGCGGCCAAACCT	0.627													T	62767306	T	T	62767306	3	4	60	1	0	0	0	0	1	0	0	0	14460	768	27	1	1214	1	SLC22A8	11	62767306	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	7063450	62767306	72239210	67	3976											
HTR3A	3359	broad.mit.edu	37	chr11	113860380	113860380	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggcccgagactggctgcgCgtgggctccgtgctggacaa	17	12	0	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:113860380C>T	uc010rxb.1	+	8	1679	c.1446C>T	c.(1444-1446)CGC>CGT	p.R482R	HTR3A_uc010rxa.1_Silent_p.R450R|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Silent_p.R429R	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	444	HA-stretch.|Cytoplasmic (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	ACTGGCTGCGCGTGGGCTCCG	0.612													T	113860380	T	T	113860380	2	4	60	1	0	0	0	0	0	0	0	1	7444	755	27	1		1	HTR3A	11	113860380	Silent	SNP	C	TCGA-06-0744-01A-01W-0348-08	51093074	113860380	21146136	68	3977											
C2CD2L	9854	broad.mit.edu	37	chr11	118984640	118984640	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgacagagcccagtgggcGggtggccaagaagacaccca	15	12	0	4			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:118984640G>A	uc001pvo.2	+	12	1924	c.1565G>A	c.(1564-1566)CGG>CAG	p.R522Q	C2CD2L_uc001pvn.2_Missense_Mutation_p.R523Q	NM_014807	NP_055622	O14523	C2C2L_HUMAN	transmembrane protein 24	522						integral to membrane					0						CCCAGTGGGCGGGTGGCCAAG	0.587													A	118984640	A	A	118984640	3	1	60	1	0	0	0	0	1	0	0	0	2153	1116	39	2	1614	2	C2CD2L	11	118984640	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	5124260	118984640	16021876	69	3978											
OR6M1	390261	broad.mit.edu	37	chr11	123676407	123676407	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcaggatggtagaaattatGtacacgtaggacccagtagt	12	7	0	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:123676407G>A	uc010rzz.1	-	1	651	c.651C>T	c.(649-651)TAC>TAT	p.Y217Y		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	217	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		TAGAAATTATGTACACGTAGG	0.493													A	123676407	A	A	123676407	2	1	60	1	0	0	0	0	0	0	0	1	11205	1372	48	3		3	OR6M1	11	123676407	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	4691767	123676407	11330109	70	3979											
OR10G9	219870	broad.mit.edu	37	chr11	123894514	123894514	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgagaccaggctccagggaCgtcgtggatggagttgtggc	17	9	0	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:123894514C>T	uc010sad.1	+	1	795	c.795C>T	c.(793-795)GAC>GAT	p.D265D		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GCTCCAGGGACGTCGTGGATG	0.517													T	123894514	T	T	123894514	2	4	60	1	0	0	0	0	0	0	0	1	10904	535	19	1		1	OR10G9	11	123894514	Silent	SNP	C	TCGA-06-0744-01A-01W-0348-08	218107	123894514	11112002	71	3980											
OR10G7	390265	broad.mit.edu	37	chr11	123908977	123908977	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagaagcaaaggaccacgatAcagtgggaggcacaggtctg	14	8	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr11:123908977A>G	uc001pzq.1	-	1	732	c.732T>C	c.(730-732)TGT>TGC	p.C244C		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GGACCACGATACAGTGGGAGG	0.567													G	123908977	G	G	123908977	2	3	60	1	0	0	0	0	0	0	0	1	10902	389	14	4		4	OR10G7	11	123908977	Silent	SNP	A	TCGA-06-0744-01A-01W-0348-08	14463	123908977	11097539	72	3981											
TSPAN9	10867	broad.mit.edu	37	chr12	3388164	3388164	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctttcctttccagtttttcAtcgtcctgttggtcatcctc	5	14	2	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr12:3388164A>G	uc001qlp.2	+	5	409	c.262A>G	c.(262-264)ATC>GTC	p.I88V		NM_006675	NP_006666	O75954	TSN9_HUMAN	tetraspanin 9	88	Helical; (Potential).					integral to plasma membrane|membrane fraction				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			CCAGTTTTTCATCGTCCTGTT	0.552													G	3388164	G	G	3388164	3	3	60	1	0	0	0	0	1	0	0	0	16651	217	8	4	272	4	TSPAN9	12	3388164	Missense_Mutation	SNP	A	TCGA-06-0744-01A-01W-0348-08		3388164	130463731	73	3982											
PSMB11	122706	broad.mit.edu	37	chr14	23511816	23511816	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgcccagtgtggccagtGctgccaagctcttgtcagcc	12	14	2	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr14:23511816G>A	uc010ake.1	+	1	441	c.382G>A	c.(382-384)GCT>ACT	p.A128T		NM_001099780	NP_001093250	A5LHX3	PSB11_HUMAN	proteasome beta 11 subunit precursor	128					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		TGTGGCCAGTGCTGCCAAGCT	0.622													A	23511816	A	A	23511816	3	1	60	1	0	0	0	0	1	0	0	0	12676	1319	46	3	384	3	PSMB11	14	23511816	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		23511816	83837724	74	3983											
ARHGAP5	394	broad.mit.edu	37	chr14	32561267	32561267	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atggaggatgaagcctacaaAtatatcactgaggctgatag	11	6	1	3			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr14:32561267A>G	uc001wrl.2	+	2	1631	c.1392A>G	c.(1390-1392)AAA>AAG	p.K464K	ARHGAP5_uc001wrm.2_Silent_p.K464K|ARHGAP5_uc001wrn.2_Silent_p.K464K|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	464	FF 3.				cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AAGCCTACAAATATATCACTG	0.373													G	32561267	G	G	32561267	2	3	60	1	0	0	0	0	0	0	0	1	886	98	4	4		4	ARHGAP5	14	32561267	Silent	SNP	A	TCGA-06-0744-01A-01W-0348-08	9049451	32561267	74788273	75	3984											
ARHGAP5	394	broad.mit.edu	37	chr14	32561946	32561946	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agatcagaaaagataaatacAtggctaatcttccatttaca	5	7	2	3			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr14:32561946A>T	uc001wrl.2	+	2	2310	c.2071A>T	c.(2071-2073)ATG>TTG	p.M691L	ARHGAP5_uc001wrm.2_Missense_Mutation_p.M691L|ARHGAP5_uc001wrn.2_Missense_Mutation_p.M691L|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	691					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AGATAAATACATGGCTAATCT	0.358													T	32561946	T	T	32561946	3	4	60	1	0	0	0	0	1	0	0	0	886	217	8	5	2073	5	ARHGAP5	14	32561946	Missense_Mutation	SNP	A	TCGA-06-0744-01A-01W-0348-08	679	32561946	74787594	76	3985											
LRFN5	145581	broad.mit.edu	37	chr14	42360832	42360832	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtaacgctgccccagtccGtgtccaaacaagctgtggga	12	12	0	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr14:42360832G>A	uc001wvm.2	+	4	2963	c.1765G>A	c.(1765-1767)GTG>ATG	p.V589M	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	589	Cytoplasmic (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GCCCCAGTCCGTGTCCAAACA	0.463										HNSCC(30;0.082)			A	42360832	A	A	42360832	3	1	60	1	0	0	0	0	1	0	0	0	8941	1145	40	1	1771	1	LRFN5	14	42360832	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	9798886	42360832	64988708	77	3986											
CDC42BPB	9578	broad.mit.edu	37	chr14	103440447	103440447	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcacgctcttggcgaagcGccactgtgtcctcaagctgt	10	15	3	0	rs149124468		TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr14:103440447G>A	uc001ymi.1	-	12	1779	c.1547C>T	c.(1546-1548)GCG>GTG	p.A516V		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	516	Potential.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TTGGCGAAGCGCCACTGTGTC	0.537													A	103440447	A	A	103440447	3	1	60	1	0	0	0	0	1	0	0	0	3073	1087	38	1	3692	1	CDC42BPB	14	103440447	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	61079615	103440447	3909093	78	3987											
AHNAK2	113146	broad.mit.edu	37	chr14	105409046	105409046	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcatcacatccgccttggGgcctttcaggtccagcttgg	12	13	3	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr14:105409046G>A	uc010axc.1	-	7	12862	c.12742C>T	c.(12742-12744)CCC>TCC	p.P4248S	AHNAK2_uc001ypx.2_Missense_Mutation_p.P4148S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4248						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCCGCCTTGGGGCCTTTCAGG	0.647													A	105409046	A	A	105409046	3	1	60	1	0	0	0	0	1	0	0	0	415	1232	43	3	4649	3	AHNAK2	14	105409046	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08	1968599	105409046	1940494	79	3988											
OR4N4	283694	broad.mit.edu	37	chr15	22383070	22383070	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtggtggagcttctaatgGtcttcaacagtggcctgatg	13	7	3	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr15:22383070G>A	uc001yuc.1	+	7	1579	c.598G>A	c.(598-600)GTC>ATC	p.V200I	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.V200I	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GCTTCTAATGGTCTTCAACAG	0.522													A	22383070	A	A	22383070	3	1	60	1	0	0	0	0	1	0	0	0	11078	1261	44	3	600	3	OR4N4	15	22383070	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		22383070	80148322	80	3989											
SYNM	23336	broad.mit.edu	37	chr15	99672043	99672043	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gtgcgggaggtgacctaagtCaggcagcgagcccgaccgga	17	11	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr15:99672043C>A	uc002bup.2	+	6	3598	c.3478C>A	c.(3478-3480)CAG>AAG	p.Q1160K	SYNM_uc002buo.2_Intron|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	1160	Tail.|Interaction with TLN1 and VCL.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						TGACCTAAGTCAGGCAGCGAG	0.587													A	99672043	A	A	99672043	3	1	60	1	0	0	0	0	1	0	0	0	15452	827	29	5	3491	5	SYNM	15	99672043	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	77288973	99672043	2859349	81	3990											
ERN2	10595	broad.mit.edu	37	chr16	23718180	23718180	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaccaggcatcctgcttccGgcctgtggaggtggaaagtg	14	10	0	0	rs148177655	byFrequency	TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr16:23718180G>A	uc002dma.3	-	6	695	c.526C>T	c.(526-528)CGG>TGG	p.R176W	ERN2_uc010bxp.2_Missense_Mutation_p.R176W|ERN2_uc010bxq.1_5'UTR	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	128	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TCCTGCTTCCGGCCTGTGGAG	0.592													A	23718180	A	A	23718180	3	1	60	1	0	0	0	0	1	0	0	0	5238	1115	39	2	2466	2	ERN2	16	23718180	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		23718180	66636573	82	3991											
TP53	7157	broad.mit.edu	37	chr17	7578394	7578394	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgctatctgagcagcgctcaTggtgggggcagcgcctcaca	14	13	3	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr17:7578394T>C	uc002gim.2	-	5	730	c.536A>G	c.(535-537)CAT>CGT	p.H179R	TP53_uc002gig.1_Missense_Mutation_p.H179R|TP53_uc002gih.2_Missense_Mutation_p.H179R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47R|TP53_uc010cng.1_Missense_Mutation_p.H47R|TP53_uc002gii.1_Missense_Mutation_p.H47R|TP53_uc010cnh.1_Missense_Mutation_p.H179R|TP53_uc010cni.1_Missense_Mutation_p.H179R|TP53_uc002gij.2_Missense_Mutation_p.H179R|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86R|TP53_uc002gio.2_Missense_Mutation_p.H47R|TP53_uc010vug.1_Missense_Mutation_p.H140R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578394	C	C	7578394	3	2	60	1	0	0	0	0	1	0	0	0	16378	1464	51	4	762	4	TP53	17	7578394	Missense_Mutation	SNP	T	TCGA-06-0744-01A-01W-0348-08		7578394	73616816	83	3992											
ZNF286B	729288	broad.mit.edu	37	chr17	18566092	18566093	+	Frame_Shift_Ins	INS	-	T	T													caatcattacatttatgaggINSttttttctctttataagttc							TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr17:18566092_18566093insT	uc010vyd.1	-	5	977_978	c.726_727insA	c.(724-729)AAACCTfs	p.K242fs		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	242_243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATTTATGAGGTTTTTTCTCTT	0.366													T	18566093	T	T	18566092	7	5	60	1	0	1	1	0	0	0	0	0	17821	1261	44	0	845	0	ZNF286B	17	18566092	Frame_Shift_Ins	INS	-	TCGA-06-0744-01A-01W-0348-08	10987698	18566092	62629118	84	3993											
LAMA1	284217	broad.mit.edu	37	chr18	7037694	7037694	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctagtgcatcttgctgagaCgggatcttcctgggactgat	12	10	2	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr18:7037694C>T	uc002knm.2	-	12	1714	c.1620G>A	c.(1618-1620)CCG>CCA	p.P540P	LAMA1_uc010wzj.1_Silent_p.P16P	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	540	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTTGCTGAGACGGGATCTTCC	0.507													T	7037694	T	T	7037694	2	4	60	1	0	0	0	0	0	0	0	1	8605	523	19	1		1	LAMA1	18	7037694	Silent	SNP	C	TCGA-06-0744-01A-01W-0348-08		7037694	71039554	85	3994											
SIGLEC15	284266	broad.mit.edu	37	chr18	43418924	43418924	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaacagcctgggccgctcCgaggccagcgtctacctgtt	12	16	1	0			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr18:43418924C>T	uc002lbl.1	+	4	887	c.738C>T	c.(736-738)TCC>TCT	p.S246S	SIGLEC15_uc010xcp.1_RNA	NM_213602	NP_998767	Q6ZMC9	SIG15_HUMAN	sialic acid binding Ig-like lectin 15 precursor	246	Extracellular (Potential).|Ig-like C2-type.					integral to membrane					0						TGGGCCGCTCCGAGGCCAGCG	0.711													T	43418924	T	T	43418924	2	4	60	1	0	0	0	0	0	0	0	1	14310	639	23	2		2	SIGLEC15	18	43418924	Silent	SNP	C	TCGA-06-0744-01A-01W-0348-08	36381230	43418924	34658324	86	3995											
HDHD2	84064	broad.mit.edu	37	chr18	44635107	44635110	+	Frame_Shift_Del	DEL	TAAG	-	-													tgagggaaactctcacaagtTaagtaaggaggtggattaat							TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr18:44635107_44635110delTAAG	uc002lcs.2	-	7	856_859	c.723_726delCTTA	c.(721-726)TACTTAfs	p.Y241fs	HDHD2_uc002lct.2_Frame_Shift_Del_p.Y151fs	NM_032124	NP_115500	Q9H0R4	HDHD2_HUMAN	haloacid dehalogenase-like hydrolase domain	241_242							hydrolase activity				0						TCTCACAAGTTAAGTAAGGAGGTG	0.407													-	44635110	-	-	44635107	7	5	60	1	0	1	0	1	0	0	0	0	7023	1751	61	0	57	0	HDHD2	18	44635107	Frame_Shift_Del	DEL	TAAG	TCGA-06-0744-01A-01W-0348-08	1216183	44635107	33442141	87	3996											
SERPINB4	6318	broad.mit.edu	37	chr18	61307011	61307011	+	Splice_Site	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaataggtttttaattttttCtgcaagggaaagaataaaag	8	2	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr18:61307011C>T	uc002ljf.2	-	6	556	c.470_splice	c.e6-1	p.E157_splice	SERPINB4_uc002lje.2_Splice_Site_p.E157_splice|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade						immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						TTAATTTTTTCTGCAAGGGAA	0.373													T	61307011	T	T	61307011	5	4	60	1	0	0	0	0	0	0	1	0	14103	927	32	3	715	3	SERPINB4	18	61307011	Splice_Site	SNP	C	TCGA-06-0744-01A-01W-0348-08	16671904	61307011	16770237	88	3997											
ZNF493	284443	broad.mit.edu	37	chr19	21606942	21606942	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accctacaaatgtgaagaatGtggcaaagcttttaaccaat	7	8	0	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr19:21606942G>A	uc002npx.2	+	2	1377	c.1097G>A	c.(1096-1098)TGT>TAT	p.C366Y	ZNF493_uc002npw.2_Missense_Mutation_p.C494Y|ZNF493_uc002npy.2_Missense_Mutation_p.C366Y	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	366	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTGAAGAATGTGGCAAAGCT	0.328													A	21606942	A	A	21606942	3	1	60	1	0	0	0	0	1	0	0	0	17941	1377	48	3	1558	3	ZNF493	19	21606942	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		21606942	37522041	89	3998											
ZNF99	7652	broad.mit.edu	37	chr19	22941129	22941129	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctttccagtatgaattatctTatgttttctaagggctgaga	8	6	2	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr19:22941129T>G	uc010xrh.1	-	5	1309	c.1309A>C	c.(1309-1311)AAG>CAG	p.K437Q		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGAATTATCTTATGTTTTCTA	0.333													G	22941129	G	G	22941129	3	3	60	1	0	0	0	0	1	0	0	0	18201	1763	61	5	1815	5	ZNF99	19	22941129	Missense_Mutation	SNP	T	TCGA-06-0744-01A-01W-0348-08	1334187	22941129	36187854	90	3999			1	13		2	2	26	N	T_C	7.913961e-05
ZNF99	7652	broad.mit.edu	37	chr19	22941154	22941154	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tttctaagggctgagaaatgCttaaaagctttgccacattc	8	8	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr19:22941154C>G	uc010xrh.1	-	5	1284	c.1284G>C	c.(1282-1284)AAG>AAC	p.K428N		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTGAGAAATGCTTAAAAGCTT	0.353													G	22941154	G	G	22941154	3	3	60	1	0	0	0	0	1	0	0	0	18201	796	28	5	1840	5	ZNF99	19	22941154	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	25	22941154	36187829	91	4000			1	13		2	2	26	N	T_C	7.913961e-05
CCDC8	83987	broad.mit.edu	37	chr19	46914965	46914965	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcagctggggcctctgccCtctgattatctgcagcctct	11	14	5	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr19:46914965C>T	uc002pep.2	-	1	1955	c.1103G>A	c.(1102-1104)AGG>AAG	p.R368K		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	368						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		GGCCTCTGCCCTCTGATTATC	0.612													T	46914965	T	T	46914965	3	4	60	1	0	0	0	0	1	0	0	0	2853	681	24	3	517	3	CCDC8	19	46914965	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	23973811	46914965	12214018	92	4001											
A1BG	1	broad.mit.edu	37	chr19	58863692	58863692	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgctgggctcagagagggcGccttccccatcggtccggta	15	14	1	1	rs138577019		TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr19:58863692G>A	uc002qsd.3	-	4	632	c.570C>T	c.(568-570)GGC>GGT	p.G190G	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	190	Ig-like V-type 2.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CAGAGAGGGCGCCTTCCCCAT	0.622													A	58863692	A	A	58863692	2	1	60	1	0	0	0	0	0	0	0	1	1	1074	38	1		1	A1BG	19	58863692	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08	11948727	58863692	265291	93	4002											
VPS16	64601	broad.mit.edu	37	chr20	2846921	2846921	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaagaagtatgcttcccgcGtgggtcccgagcagaaggtc	13	12	0	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr20:2846921G>A	uc002whe.2	+	23	2383	c.2335G>A	c.(2335-2337)GTG>ATG	p.V779M	VPS16_uc002whh.2_Intron|PTPRA_uc002whj.2_Intron|VPS16_uc002whf.2_Missense_Mutation_p.V635M|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Missense_Mutation_p.V465M|VPS16_uc002whi.2_Missense_Mutation_p.V263M	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	779					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						TGCTTCCCGCGTGGGTCCCGA	0.552													A	2846921	A	A	2846921	3	1	60	1	0	0	0	0	1	0	0	0	17190	1145	40	1	2425	1	VPS16	20	2846921	Missense_Mutation	SNP	G	TCGA-06-0744-01A-01W-0348-08		2846921	60178599	94	4003											
RALGAPA2	57186	broad.mit.edu	37	chr20	20475882	20475882	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtctctggagtgttcagacCagacgatatggacctcgtca	11	10	3	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr20:20475882C>A	uc002wrz.2	-	36	5389	c.5246G>T	c.(5245-5247)TGG>TTG	p.W1749L	RALGAPA2_uc010gcx.2_Missense_Mutation_p.W1453L|RALGAPA2_uc010zsg.1_Missense_Mutation_p.W1197L|RALGAPA2_uc002wsa.1_Missense_Mutation_p.W521L	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1749	Rap-GAP.				activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						GTGTTCAGACCAGACGATATG	0.438													A	20475882	A	A	20475882	3	1	60	1	0	0	0	0	1	0	0	0	13014	595	21	5	391	5	RALGAPA2	20	20475882	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	17628961	20475882	42549638	95	4004											
CHRNA4	1137	broad.mit.edu	37	chr20	61978100	61978100	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggtcccttcctagatcatgCcagccagccagggcggcagg	13	15	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr20:61978100C>T	uc002yes.2	-	6	2052	c.1874G>A	c.(1873-1875)GGC>GAC	p.G625D	CHRNA4_uc002yet.1_Missense_Mutation_p.G449D|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.G554D|CHRNA4_uc002yev.1_Missense_Mutation_p.G449D|CHRNA4_uc010gkf.1_Missense_Mutation_p.G449D	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	625					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CTAGATCATGCCAGCCAGCCA	0.677													T	61978100	T	T	61978100	3	4	60	1	0	0	0	0	1	0	0	0	3385	739	26	3	13	3	CHRNA4	20	61978100	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08	41502218	61978100	1047420	96	4005											
RFPL2	10739	broad.mit.edu	37	chr22	32589175	32589175	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttggaagagtgcagccatGtccactgccaggggaaaagt	13	9	1	1			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chr22:32589175G>A	uc003amg.3	-	4	1206	c.270C>T	c.(268-270)GAC>GAT	p.D90D	RFPL2_uc003ame.3_Silent_p.D29D|RFPL2_uc003amf.3_5'UTR|RFPL2_uc003amh.3_5'UTR	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	90							zinc ion binding			skin(1)	1						GTGCAGCCATGTCCACTGCCA	0.478													A	32589175	A	A	32589175	2	1	60	1	0	0	0	0	0	0	0	1	13254	1368	48	3		3	RFPL2	22	32589175	Silent	SNP	G	TCGA-06-0744-01A-01W-0348-08		32589175	18715391	97	4006											
CXorf57	55086	broad.mit.edu	37	chrX	105881005	105881005	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggaggtcatagaggccagcCgtatacgtatgatgccaagg	14	8	1	2			TCGA-06-0744-01A-01W-0348-08	TCGA-06-0744-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	d80afd62-48a6-4da4-8026-e6384e86cf62	ac87a0e4-84c8-4202-9405-43461e1b7e66	g.chrX:105881005C>T	uc004emi.3	+	8	1575	c.1424C>T	c.(1423-1425)CCG>CTG	p.P475L	CXorf57_uc004emj.3_Missense_Mutation_p.P475L|CXorf57_uc004emh.2_Missense_Mutation_p.P475L	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	475										ovary(1)|lung(1)|breast(1)	3						AGAGGCCAGCCGTATACGTAT	0.368													T	105881005	T	T	105881005	3	4	60	1	0	0	0	0	1	0	0	0	4113	652	23	2	1454	2	CXorf57	23	105881005	Missense_Mutation	SNP	C	TCGA-06-0744-01A-01W-0348-08		105881005	49389555	98	4007											
PTCHD2	57540	broad.mit.edu	37	chr1	11596726	11596726	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctataagattcccctgcccGcaggggcctccctatagccc	9	17	0	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr1:11596726G>T	uc001ash.3	+	21	4300	c.4162G>T	c.(4162-4164)GCA>TCA	p.A1388S		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1388	Cytoplasmic (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCCCCTGCCCGCAGGGGCCTC	0.662													T	11596726	T	T	11596726	3	4	61	1	0	0	0	0	1	0	0	0	12733	1087	38	5	4240	5	PTCHD2	1	11596726	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08		11596726	237653895	1	4008											
RYR2	6262	broad.mit.edu	37	chr1	237948008	237948008	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaagttgcagaactgttagcCaacatgccagaccccactca	7	13	1	2			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr1:237948008C>G	uc001hyl.1	+	90	13116	c.12996C>G	c.(12994-12996)GCC>GCG	p.A4332A	RYR2_uc010pya.1_Silent_p.A747A	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4332					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AACTGTTAGCCAACATGCCAG	0.557													G	237948008	G	G	237948008	2	3	61	1	0	0	0	0	0	0	0	1	13769	581	21	5		5	RYR2	1	237948008	Silent	SNP	C	TCGA-06-0745-01A-01W-0348-08	226351282	237948008	11302613	2	4009											
SMYD3	64754	broad.mit.edu	37	chr1	246027126	246027126	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgccttcagttcttcaatTtttttcagggattcttgaac	7	8	5	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr1:246027126T>G	uc001ibl.2	-	9	971	c.876A>C	c.(874-876)AAA>AAC	p.K292N	SMYD3_uc001ibk.2_Missense_Mutation_p.K233N|SMYD3_uc001ibi.2_Missense_Mutation_p.K103N|SMYD3_uc001ibj.2_Missense_Mutation_p.K103N	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	292						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		GTTCTTCAATTTTTTTCAGGG	0.358													G	246027126	G	G	246027126	3	3	61	1	0	0	0	0	1	0	0	0	14823	1838	64	5	426	5	SMYD3	1	246027126	Missense_Mutation	SNP	T	TCGA-06-0745-01A-01W-0348-08	8079118	246027126	3223495	3	4010											
MYT1L	23040	broad.mit.edu	37	chr2	1812887	1812887	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatggtcagcatctgctctcCagaaagctttgccttcttca	8	12	5	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr2:1812887C>T	uc002qxe.2	-	22	3960	c.3133G>A	c.(3133-3135)GGA>AGA	p.G1045R	MYT1L_uc002qxd.2_Missense_Mutation_p.G1043R|MYT1L_uc010ewk.2_Missense_Mutation_p.G41R	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1045					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ATCTGCTCTCCAGAAAGCTTT	0.592													T	1812887	T	T	1812887	3	4	61	1	0	0	0	0	1	0	0	0	10107	603	21	3	443	3	MYT1L	2	1812887	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08		1812887	241386486	4	4011											
LCT	3938	broad.mit.edu	37	chr2	136570155	136570155	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcaggtgttttgtggggcGttgctgatgaggcgggaggt	20	4	0	2			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr2:136570155G>A	uc002tuu.1	-	7	2090	c.2079C>T	c.(2077-2079)AAC>AAT	p.N693N		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	693	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TTTGTGGGGCGTTGCTGATGA	0.547													A	136570155	A	A	136570155	2	1	61	1	0	0	0	0	0	0	0	1	8693	1136	40	1		1	LCT	2	136570155	Silent	SNP	G	TCGA-06-0745-01A-01W-0348-08	134757268	136570155	106629218	5	4012											
OR5K4	403278	broad.mit.edu	37	chr3	98072858	98072858	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attaatttatgtagagcgtcGtcttctcacaccaatgtaca	6	9	2	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr3:98072858G>A	uc011bgv.1	+	1	161	c.161G>A	c.(160-162)CGT>CAT	p.R54H		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GTAGAGCGTCGTCTTCTCACA	0.473													A	98072858	A	A	98072858	3	1	61	1	0	0	0	0	1	0	0	0	11169	1145	40	1	163	1	OR5K4	3	98072858	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08		98072858	99949572	6	4013											
FSTL1	11167	broad.mit.edu	37	chr3	120122088	120122088	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatttcttaggttaggcataCtcttctcaggagggttgaaa	10	6	3	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr3:120122088C>T	uc003eds.2	-	8	869	c.694_splice	c.e8+1	p.K232_splice	FSTL1_uc011bjh.1_Splice_Site_p.K197_splice	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor						BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		GTTAGGCATACTCTTCTCAGG	0.443													T	120122088	T	T	120122088	5	4	61	1	0	0	0	0	0	0	1	0	6077	579	20	3	247	3	FSTL1	3	120122088	Splice_Site	SNP	C	TCGA-06-0745-01A-01W-0348-08	22049230	120122088	77900342	7	4014											
CSN1S1	1446	broad.mit.edu	37	chr4	70810645	70810645	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caaatcatgcagtatgttccTttcccaccgttttccgacat	5	13	1	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr4:70810645T>C	uc003hep.1	+	15	529	c.480T>C	c.(478-480)CCT>CCC	p.P160P	CSN1S1_uc003heq.1_Silent_p.P151P|CSN1S1_uc003her.1_Silent_p.P152P	NM_001890	NP_001881	P47710	CASA1_HUMAN	casein alpha s1 isoform 1	160						extracellular region	protein binding|transporter activity				0						AGTATGTTCCTTTCCCACCGT	0.403													C	70810645	C	C	70810645	2	2	61	1	0	0	0	0	0	0	0	1	3947	1596	56	4		4	CSN1S1	4	70810645	Silent	SNP	T	TCGA-06-0745-01A-01W-0348-08		70810645	120343631	8	4015											
SEC31A	22872	broad.mit.edu	37	chr4	83785658	83785658	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctccttttctgttacaacctGactaatgaacacatggtgct	6	11	1	2			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr4:83785658G>A	uc003hnf.2	-	11	1455	c.1291C>T	c.(1291-1293)CAG>TAG	p.Q431*	SEC31A_uc003hne.2_Nonsense_Mutation_p.Q203*|SEC31A_uc011ccl.1_Nonsense_Mutation_p.Q431*|SEC31A_uc003hnl.2_Nonsense_Mutation_p.Q431*|SEC31A_uc003hng.2_Nonsense_Mutation_p.Q431*|SEC31A_uc003hnh.2_Nonsense_Mutation_p.Q431*|SEC31A_uc003hni.2_Nonsense_Mutation_p.Q431*|SEC31A_uc003hnj.2_Nonsense_Mutation_p.Q431*|SEC31A_uc011ccm.1_Nonsense_Mutation_p.Q426*|SEC31A_uc011ccn.1_Nonsense_Mutation_p.Q431*|SEC31A_uc003hnk.2_Nonsense_Mutation_p.Q431*|SEC31A_uc003hnm.2_Nonsense_Mutation_p.Q431*|SEC31A_uc003hnn.1_Nonsense_Mutation_p.Q431*|SEC31A_uc003hno.2_Nonsense_Mutation_p.Q431*	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	431	Interaction with SEC13.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				GTTACAACCTGACTAATGAAC	0.438													A	83785658	A	A	83785658	4	1	61	1	0	0	0	0	0	1	0	0	13998	1299	45	3	2439	3	SEC31A	4	83785658	Nonsense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08	12975013	83785658	107368618	9	4016											
MAST4	375449	broad.mit.edu	37	chr5	66416900	66416900	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgggaaagtgattttgaaaCgattaaattgattagcaatg	10	3	0	3			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr5:66416900C>T	uc003jut.1	+	13	1216	c.1148C>T	c.(1147-1149)ACG>ATG	p.T383M	MAST4_uc003juu.1_Missense_Mutation_p.T393M|MAST4_uc011cra.1_Missense_Mutation_p.T366M|MAST4_uc003juv.2_Missense_Mutation_p.T378M|MAST4_uc003juw.2_Missense_Mutation_p.T378M	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	575	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GATTTTGAAACGATTAAATTG	0.328													T	66416900	T	T	66416900	3	4	61	1	0	0	0	0	1	0	0	0	9327	536	19	1	1899	1	MAST4	5	66416900	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08		66416900	114498360	10	4017											
GPR98	84059	broad.mit.edu	37	chr5	89981650	89981650	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaactattgcgcaactaattAtcattgccaatgatgatgca	6	8	1	2			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr5:89981650A>G	uc003kju.2	+	29	6424	c.6328A>G	c.(6328-6330)ATC>GTC	p.I2110V	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2110	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCAACTAATTATCATTGCCAA	0.413													G	89981650	G	G	89981650	3	3	61	1	0	0	0	0	1	0	0	0	6721	449	16	4	6442	4	GPR98	5	89981650	Missense_Mutation	SNP	A	TCGA-06-0745-01A-01W-0348-08	23564750	89981650	90933610	11	4018											
PCDHB3	56132	broad.mit.edu	37	chr5	140481632	140481632	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccgcgagaacaacagccccGccctgcacatcggcagtgtc	10	17	0	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr5:140481632G>A	uc003lio.2	+	1	1399	c.1399G>A	c.(1399-1401)GCC>ACC	p.A467T	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	467	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAACAGCCCCGCCCTGCACAT	0.622													A	140481632	A	A	140481632	3	1	61	1	0	0	0	0	1	0	0	0	11543	1087	38	1	1401	1	PCDHB3	5	140481632	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08	50499982	140481632	40433628	12	4019											
PCDHB13	56123	broad.mit.edu	37	chr5	140595599	140595599	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgctgagcgagcgcgacgCggccaagcacaggctggtgg	18	12	0	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr5:140595599C>T	uc003lja.1	+	1	2091	c.1904C>T	c.(1903-1905)GCG>GTG	p.A635V		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	635	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCGCGACGCGGCCAAGCAC	0.692													T	140595599	T	T	140595599	3	4	61	1	0	0	0	0	1	0	0	0	11538	768	27	1	1906	1	PCDHB13	5	140595599	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08	113967	140595599	40319661	13	4020											
SNX9	51429	broad.mit.edu	37	chr6	158342573	158342573	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcgcttgcaggccgctttgaAgaggaatttatcaaaatgcg	11	8	1	2			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr6:158342573A>T	uc003qqv.1	+	10	1133	c.960A>T	c.(958-960)GAA>GAT	p.E320D		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	320	PX.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		GCCGCTTTGAAGAGGAATTTA	0.423													T	158342573	T	T	158342573	3	4	61	1	0	0	0	0	1	0	0	0	14909	69	3	5	998	5	SNX9	6	158342573	Missense_Mutation	SNP	A	TCGA-06-0745-01A-01W-0348-08		158342573	12772494	14	4021											
FTSJ2	29960	broad.mit.edu	37	chr7	2281798	2281798	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcagcgcccagctcaccCcgccattggtgttccccgcg	11	19	1	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr7:2281798C>T	uc003slm.2	-	1	36	c.7G>A	c.(7-9)GGG>AGG	p.G3R	FTSJ2_uc003slk.2_5'UTR|FTSJ2_uc003sll.2_5'UTR|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_5'UTR|NUDT1_uc003slp.1_5'Flank|NUDT1_uc003slq.1_5'Flank|NUDT1_uc003slr.1_5'Flank|NUDT1_uc003sls.1_5'Flank|NUDT1_uc003slt.1_5'Flank|NUDT1_uc003slu.1_5'Flank|NUDT1_uc003slv.1_5'Flank	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	3					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		CCAGCTCACCCCGCCATTGGT	0.736													T	2281798	T	T	2281798	3	4	61	1	0	0	0	0	1	0	0	0	6088	637	22	3	745	3	FTSJ2	7	2281798	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08		2281798	156856865	15	4022											
COL28A1	340267	broad.mit.edu	37	chr7	7412882	7412882	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgcatcttcaaacatgtcGttggctgcttgcagagcagt	10	10	2	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr7:7412882G>A	uc003src.1	-	32	2772	c.2655C>T	c.(2653-2655)AAC>AAT	p.N885N	COL28A1_uc011jxe.1_Silent_p.N568N	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	885	VWFA 2.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CAAACATGTCGTTGGCTGCTT	0.488													A	7412882	A	A	7412882	2	1	61	1	0	0	0	0	0	0	0	1	3686	1136	40	1		1	COL28A1	7	7412882	Silent	SNP	G	TCGA-06-0745-01A-01W-0348-08	5131084	7412882	151725781	16	4023											
ABCB1	5243	broad.mit.edu	37	chr7	87190619	87190619	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcctccaaatgcaatcacagTtctaattgctgccaagacct	5	13	2	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr7:87190619T>A	uc003uiz.1	-	9	1205	c.787A>T	c.(787-789)ACT>TCT	p.T263S	ABCB1_uc011khc.1_Missense_Mutation_p.T199S	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	263	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GCAATCACAGTTCTAATTGCT	0.343													A	87190619	A	A	87190619	3	1	61	1	0	0	0	0	1	0	0	0	40	1725	60	5	3139	5	ABCB1	7	87190619	Missense_Mutation	SNP	T	TCGA-06-0745-01A-01W-0348-08	79777737	87190619	71948044	17	4024											
DLD	1738	broad.mit.edu	37	chr7	107557761	107557761	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttgctggtccaatgctggctCacaaagcagaggatgaaggc	13	9	1	2			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr7:107557761C>T	uc003vet.2	+	11	1200	c.1090C>T	c.(1090-1092)CAC>TAC	p.H364Y	DLD_uc011kmg.1_Missense_Mutation_p.H316Y|DLD_uc011kmh.1_Missense_Mutation_p.H341Y|DLD_uc011kmi.1_Missense_Mutation_p.H265Y	NM_000108	NP_000099	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase precursor	364	FAD.				branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			central_nervous_system(1)	1					NADH(DB00157)	AATGCTGGCTCACAAAGCAGA	0.428													T	107557761	T	T	107557761	3	4	61	1	0	0	0	0	1	0	0	0	4551	826	29	3	1132	3	DLD	7	107557761	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08	20367142	107557761	51580902	18	4025											
TFEC	22797	broad.mit.edu	37	chr7	115582025	115582025	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aattctcgggctctctgttgTtctttttgtagccacttgat	8	9	3	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr7:115582025T>C	uc003vhj.1	-	7	769	c.585A>G	c.(583-585)GAA>GAG	p.E195E	TFEC_uc003vhk.1_Silent_p.E166E|TFEC_uc003vhl.3_Silent_p.E166E|TFEC_uc011kmw.1_Silent_p.E285E	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	195						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			CTCTCTGTTGTTCTTTTTGTA	0.408													C	115582025	C	C	115582025	2	2	61	1	0	0	0	0	0	0	0	1	15799	1722	60	4		4	TFEC	7	115582025	Silent	SNP	T	TCGA-06-0745-01A-01W-0348-08	8024264	115582025	43556638	19	4026											
MYOM2	9172	broad.mit.edu	37	chr8	2092880	2092880	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagcccaagctcatccccgCgtctgcctcagcggcaggcc	10	19	3	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr8:2092880C>T	uc003wpx.3	+	37	4511	c.4373C>T	c.(4372-4374)GCG>GTG	p.A1458V	MYOM2_uc011kwi.1_Missense_Mutation_p.A883V	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1458					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTCATCCCCGCGTCTGCCTCA	0.587													T	2092880	T	T	2092880	3	4	61	1	0	0	0	0	1	0	0	0	10092	768	27	1	4515	1	MYOM2	8	2092880	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08		2092880	144271142	20	4027											
RB1CC1	9821	broad.mit.edu	37	chr8	53573548	53573548	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catataatctctttccatctTtgactaaagcaccagcccac	3	14	2	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr8:53573548T>C	uc003xre.3	-	11	2123	c.1565A>G	c.(1564-1566)AAA>AGA	p.K522R	RB1CC1_uc003xrf.3_Missense_Mutation_p.K522R	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	522					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CTTTCCATCTTTGACTAAAGC	0.284													C	53573548	C	C	53573548	3	2	61	1	0	0	0	0	1	0	0	0	13099	1841	64	4	3275	4	RB1CC1	8	53573548	Missense_Mutation	SNP	T	TCGA-06-0745-01A-01W-0348-08	51480668	53573548	92790474	21	4028											
C8orf34	116328	broad.mit.edu	37	chr8	69381052	69381052	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aagcccttgagaatctctctCgaagtaagttcatttacttg	7	9	3	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr8:69381052C>T	uc010lyz.2	+	4	524	c.475C>T	c.(475-477)CGA>TGA	p.R159*	C8orf34_uc010lyy.1_Nonsense_Mutation_p.R159*|C8orf34_uc003xyb.2_Nonsense_Mutation_p.R134*	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	159					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			GAATCTCTCTCGAAGTAAGTT	0.393													T	69381052	T	T	69381052	4	4	61	1	0	0	0	0	0	1	0	0	2422	876	31	2	410	2	C8orf34	8	69381052	Nonsense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08	15807504	69381052	76982970	22	4029											
FAM135B	51059	broad.mit.edu	37	chr8	139164211	139164211	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cggggccctgctggttgtcaGcatctaaaactatctccacc	9	14	3	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr8:139164211G>C	uc003yuy.2	-	13	2678	c.2507C>G	c.(2506-2508)GCT>GGT	p.A836G	FAM135B_uc003yux.2_Missense_Mutation_p.A737G|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.A398G|FAM135B_uc003yvb.2_Missense_Mutation_p.A398G	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	836										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGGTTGTCAGCATCTAAAAC	0.522										HNSCC(54;0.14)			C	139164211	C	C	139164211	3	2	61	1	0	0	0	0	1	0	0	0	5449	971	34	5	1745	5	FAM135B	8	139164211	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08	69783159	139164211	7199811	23	4030											
FAM120A	23196	broad.mit.edu	37	chr9	96294445	96294445	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ttccatgcaaagggtgaaatCaaaattgctgtttctattga	8	6	2	2			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr9:96294445C>A	uc004atw.2	+	10	1768	c.1743C>A	c.(1741-1743)ATC>ATA	p.I581I	FAM120A_uc004atx.2_Silent_p.I363I|FAM120A_uc004aty.2_Silent_p.I362I|FAM120A_uc004atz.2_Silent_p.I230I|FAM120A_uc010mrg.2_5'UTR	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	581						cytoplasm|plasma membrane	RNA binding				0						AGGGTGAAATCAAAATTGCTG	0.393													A	96294445	A	A	96294445	2	1	61	1	0	0	0	0	0	0	0	1	5415	816	29	5		5	FAM120A	9	96294445	Silent	SNP	C	TCGA-06-0745-01A-01W-0348-08		96294445	44918986	24	4031											
QRFP	347148	broad.mit.edu	37	chr9	133768879	133768879	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtagccattgagctcctcaGccaggttccctaacgggccg	11	14	1	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr9:133768879G>A	uc011mcb.1	-	1	347	c.347C>T	c.(346-348)GCT>GTT	p.A116V		NM_198180	NP_937823	P83859	OX26_HUMAN	RF(Arg-Phe)amide family 26 amino acid peptide	116					locomotory behavior|neuropeptide signaling pathway|positive regulation of blood pressure|regulation of feeding behavior	extracellular region	neuropeptide hormone activity|orexigenic neuropeptide QRFP receptor binding				0	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.17e-05)|Epithelial(140;0.000267)		GAGCTCCTCAGCCAGGTTCCC	0.632													A	133768879	A	A	133768879	3	1	61	1	0	0	0	0	1	0	0	0	12877	971	34	3	66	3	QRFP	9	133768879	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08	37474434	133768879	7444552	25	4032											
EGR2	1959	broad.mit.edu	37	chr10	64574066	64574066	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cactcacaatattgattatgCcttctgggtagcagctggca	9	10	2	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr10:64574066C>G	uc010qim.1	-	3	486	c.332G>C	c.(331-333)GGC>GCC	p.G111A	EGR2_uc010qin.1_Missense_Mutation_p.G61A|EGR2_uc001jmi.2_Missense_Mutation_p.G111A|EGR2_uc010qio.1_Missense_Mutation_p.G124A|EGR2_uc009xph.2_Missense_Mutation_p.G111A	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	111					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					ATTGATTATGCCTTCTGGGTA	0.547													G	64574066	G	G	64574066	3	3	61	1	0	0	0	0	1	0	0	0	4972	739	26	5	1102	5	EGR2	10	64574066	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08		64574066	70960681	26	4033											
ATE1	11101	broad.mit.edu	37	chr10	123683779	123683779	+	Splice_Site	DEL	A	-	-													tctttgtatctggaagctttAccttcgccatcctcggtcta							TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr10:123683779delA	uc001lfp.2	-	2	252	c.170_splice	c.e2+1	p.R57_splice	ATE1_uc001lfq.2_Splice_Site_p.R57_splice|ATE1_uc010qtr.1_Splice_Site|ATE1_uc010qts.1_Intron|ATE1_uc010qtt.1_Splice_Site_p.R50_splice|ATE1_uc001lfr.2_Splice_Site|ATE1_uc009xzu.2_Intron	NM_007041	NP_008972	O95260	ATE1_HUMAN	arginyltransferase 1 isoform 2						protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity				0		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				TGGAAGCTTTACCTTCGCCAT	0.413													-	123683779	-	-	123683779	8	5	61	1	0	1	0	1	0	0	1	0	1078	405	14	0	1561	0	ATE1	10	123683779	Splice_Site	DEL	A	TCGA-06-0745-01A-01W-0348-08	59109713	123683779	11850968	27	4034											
ART1	417	broad.mit.edu	37	chr11	3681476	3681476	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctggagaggaagaggtgctgAtccccccctttgagaccttc	12	12	0	4			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr11:3681476A>T	uc001lye.1	+	3	828	c.727A>T	c.(727-729)ATC>TTC	p.I243F	ART1_uc009yeb.1_Missense_Mutation_p.I243F	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	243					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	AGAGGTGCTGATCCCCCCCTT	0.607													T	3681476	T	T	3681476	3	4	61	1	0	0	0	0	1	0	0	0	997	333	12	5	733	5	ART1	11	3681476	Missense_Mutation	SNP	A	TCGA-06-0745-01A-01W-0348-08		3681476	131325040	28	4035											
KIF18A	81930	broad.mit.edu	37	chr11	28058009	28058009	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcattaaggttactgtagaCggattttgaaaagcttttct	8	5	2	2			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr11:28058009C>T	uc001msc.2	-	14	2333	c.2151G>A	c.(2149-2151)CCG>CCA	p.P717P		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	717					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						TTACTGTAGACGGATTTTGAA	0.363													T	28058009	T	T	28058009	2	4	61	1	0	0	0	0	0	0	0	1	8280	523	19	1		1	KIF18A	11	28058009	Silent	SNP	C	TCGA-06-0745-01A-01W-0348-08	24376533	28058009	106948507	29	4036											
AHNAK	79026	broad.mit.edu	37	chr11	62298733	62298733	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaggcatcttaaacttcggGcctttcaacttcccttcagg	7	13	4	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr11:62298733G>A	uc001ntl.2	-	5	3456	c.3156C>T	c.(3154-3156)GGC>GGT	p.G1052G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1052					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TAAACTTCGGGCCTTTCAACT	0.443													A	62298733	A	A	62298733	2	1	61	1	0	0	0	0	0	0	0	1	414	1190	42	3		3	AHNAK	11	62298733	Silent	SNP	G	TCGA-06-0745-01A-01W-0348-08	34240724	62298733	72707783	30	4037											
OR4D5	219875	broad.mit.edu	37	chr11	123811134	123811134	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattccccatggacaaggccGtctctgtgctatacacaatt	7	13	1	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr11:123811134G>A	uc001pzk.1	+	1	811	c.811G>A	c.(811-813)GTC>ATC	p.V271I		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	271	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGACAAGGCCGTCTCTGTGCT	0.493													A	123811134	A	A	123811134	3	1	61	1	0	0	0	0	1	0	0	0	11057	1145	40	1	813	1	OR4D5	11	123811134	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08	61512401	123811134	11195382	31	4038											
KCNC2	3747	broad.mit.edu	37	chr12	75601564	75601564	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccgggggacagcgggggcGctctcggcggcggcgacagt	21	13	1	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr12:75601564G>A	uc001sxg.1	-	2	744	c.200C>T	c.(199-201)GCG>GTG	p.A67V	KCNC2_uc009zry.2_Missense_Mutation_p.A67V|KCNC2_uc001sxe.2_Missense_Mutation_p.A67V|KCNC2_uc001sxf.2_Missense_Mutation_p.A67V|KCNC2_uc010stw.1_Missense_Mutation_p.A67V	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	67	Gly/Pro-rich (insert).|Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						cagcgggggcgctctcggcgg	0.542													A	75601564	A	A	75601564	3	1	61	1	0	0	0	0	1	0	0	0	8015	1087	38	1	1798	1	KCNC2	12	75601564	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08		75601564	58250331	32	4039											
MYCBP2	23077	broad.mit.edu	37	chr13	77835447	77835447	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtaattggtagctcaacccAttttcctgctgaaggaccac	8	11	1	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr13:77835447A>G	uc001vkf.2	-	13	1688	c.1597T>C	c.(1597-1599)TGG>CGG	p.W533R	MYCBP2_uc010aev.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGCTCAACCCATTTTCCTGCT	0.378													G	77835447	G	G	77835447	3	3	61	1	0	0	0	0	1	0	0	0	10018	217	8	4	12613	4	MYCBP2	13	77835447	Missense_Mutation	SNP	A	TCGA-06-0745-01A-01W-0348-08		77835447	37334431	33	4040											
AKAP6	9472	broad.mit.edu	37	chr14	33290671	33290671	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ggatgagtgaggatgccctgGaatgggatgaaatggacata	16	4	0	3			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr14:33290671G>C	uc001wrq.2	+	13	3822	c.3652G>C	c.(3652-3654)GAA>CAA	p.E1218Q		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1218					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GGATGCCCTGGAATGGGATGA	0.393													C	33290671	C	C	33290671	3	2	61	1	0	0	0	0	1	0	0	0	455	1175	41	5	3698	5	AKAP6	14	33290671	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08		33290671	74058869	34	4041											
SMEK1	55671	broad.mit.edu	37	chr14	91937214	91937214	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agcatgcttcgaggccataaGaactagcactctccggagga	11	11	1	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr14:91937214G>C	uc001xzn.2	-	10	2449	c.1627C>G	c.(1627-1629)CTT>GTT	p.L543V	SMEK1_uc001xzm.2_Missense_Mutation_p.L530V|SMEK1_uc001xzo.2_Missense_Mutation_p.L530V|SMEK1_uc010atz.2_Missense_Mutation_p.L304V|SMEK1_uc001xzp.1_RNA	NM_032560	NP_115949	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1	543						microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		GAGGCCATAAGAACTAGCACT	0.333													C	91937214	C	C	91937214	3	2	61	1	0	0	0	0	1	0	0	0	14793	942	33	5	898	5	SMEK1	14	91937214	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08	58646543	91937214	15412326	35	4042											
TRPM1	4308	broad.mit.edu	37	chr15	31294188	31294188	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gatgtccatgtaaactttttGacctgagagatgggaatccc	10	8	0	3			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr15:31294188G>T	uc001zfm.2	-	27	4777	c.4649C>A	c.(4648-4650)TCA>TAA	p.S1550*	TRPM1_uc010azy.2_Nonsense_Mutation_p.S1457*|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1550	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TAAACTTTTTGACCTGAGAGA	0.428													T	31294188	T	T	31294188	4	4	61	1	0	0	0	0	0	1	0	0	16582	1294	45	5	166	5	TRPM1	15	31294188	Nonsense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08		31294188	71237204	36	4043											
SPTBN5	51332	broad.mit.edu	37	chr15	42178160	42178160	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cggagggctgccttgtgctgGaagcgccgggccagggtttc	18	11	0	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr15:42178160G>C	uc001zos.2	-	7	1521	c.1188C>G	c.(1186-1188)TTC>TTG	p.F396L		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	431	Spectrin 2.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CCTTGTGCTGGAAGCGCCGGG	0.667													C	42178160	C	C	42178160	3	2	61	1	0	0	0	0	1	0	0	0	15121	1165	41	5	9979	5	SPTBN5	15	42178160	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08	10883972	42178160	60353232	37	4044											
OR1F1	4992	broad.mit.edu	37	chr16	3254556	3254556	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctcacacagatgtatttcGttttcatgttcgtggacatg	9	8	2	1	rs141236935		TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr16:3254556G>A	uc010uwu.1	+	1	310	c.310G>A	c.(310-312)GTT>ATT	p.V104I		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATGTATTTCGTTTTCATGTT	0.498													A	3254556	A	A	3254556	3	1	61	1	0	0	0	0	1	0	0	0	10956	1145	40	1	312	1	OR1F1	16	3254556	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08		3254556	87100197	38	4045											
CIITA	4261	broad.mit.edu	37	chr16	10992859	10992859	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagaaaagtcagaaaagaCgtgagtgagcccctccctga	12	10	1	6			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr16:10992859C>T	uc002dai.3	+	5	569	c.436C>T	c.(436-438)CCC>TCC	p.P146S	CIITA_uc002daj.3_Missense_Mutation_p.P147S|CIITA_uc002dak.3_Missense_Mutation_p.P146S|CIITA_uc002dag.2_Missense_Mutation_p.P146S|CIITA_uc002dah.2_Missense_Mutation_p.P147S|CIITA_uc010bup.1_Missense_Mutation_p.P146S	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	146					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						TCAGAAAAGACGTGAGTGAGC	0.512			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								T	10992859	T	T	10992859	3	4	61	1	0	0	0	0	1	0	0	0	3428	550	19	1	454	1	CIITA	16	10992859	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08	7738303	10992859	79361894	39	4046											
GTF3C1	2975	broad.mit.edu	37	chr16	27483187	27483187	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	caagctcctcttctggcactCcatgaaggccttcacaagaa	7	14	3	2			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr16:27483187C>G	uc002dov.1	-	30	4448	c.4408G>C	c.(4408-4410)GAG>CAG	p.E1470Q	GTF3C1_uc002dou.2_Missense_Mutation_p.E1470Q	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1470						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TTCTGGCACTCCATGAAGGCC	0.617													G	27483187	G	G	27483187	3	3	61	1	0	0	0	0	1	0	0	0	6872	864	30	5	1953	5	GTF3C1	16	27483187	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08	16490328	27483187	62871566	40	4047											
CHD9	80205	broad.mit.edu	37	chr16	53190481	53190481	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaaagctttgtggcacaccaTgactttgccttatttcaggc	8	10	1	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr16:53190481T>A	uc002ehb.2	+	1	644	c.480T>A	c.(478-480)CAT>CAA	p.H160Q	CHD9_uc002egy.2_Missense_Mutation_p.H160Q|CHD9_uc002egz.1_Missense_Mutation_p.H160Q|CHD9_uc002eha.1_Missense_Mutation_p.H160Q|CHD9_uc002ehc.2_Missense_Mutation_p.H160Q	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	160					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TGGCACACCATGACTTTGCCT	0.388													A	53190481	A	A	53190481	3	1	61	1	0	0	0	0	1	0	0	0	3332	1461	51	5	482	5	CHD9	16	53190481	Missense_Mutation	SNP	T	TCGA-06-0745-01A-01W-0348-08	25707294	53190481	37164272	41	4048											
CTU2	348180	broad.mit.edu	37	chr16	88779258	88779258	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agactgaggctctttcccaaCtgttctgctcagtgaggaca	10	11	3	3			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr16:88779258C>A	uc002flm.2	+	7	730	c.682C>A	c.(682-684)CTG>ATG	p.L228M	CTU2_uc002fln.2_Missense_Mutation_p.L228M|CTU2_uc010chz.2_Missense_Mutation_p.L299M|CTU2_uc010cia.2_Missense_Mutation_p.L141M	NM_001012759	NP_001012777	Q2VPK5	CTU2_HUMAN	cytoplasmic tRNA 2-thiolation protein 2 isoform	228					tRNA thio-modification|tRNA wobble uridine modification	cytoplasm|protein complex|soluble fraction	protein binding			skin(1)	1						TCTTTCCCAACTGTTCTGCTC	0.562													A	88779258	A	A	88779258	3	1	61	1	0	0	0	0	1	0	0	0	4048	564	20	5	708	5	CTU2	16	88779258	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08	35588777	88779258	1575495	42	4049											
ITGB4	3691	broad.mit.edu	37	chr17	73733432	73733432	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtggtgcgctgctccttcCgggacgaggatgacgactgc	16	11	0	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr17:73733432C>T	uc002jpg.2	+	17	2207	c.2020C>T	c.(2020-2022)CGG>TGG	p.R674W	ITGB4_uc002jph.2_Missense_Mutation_p.R674W|ITGB4_uc010dgo.2_Missense_Mutation_p.R674W|ITGB4_uc002jpi.3_Missense_Mutation_p.R674W|ITGB4_uc010dgp.1_Missense_Mutation_p.R674W|ITGB4_uc002jpj.2_Missense_Mutation_p.R674W	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	674	Extracellular (Potential).			IHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDEL KRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHK KK -> STRASARTYAPACSARRGAPARRRGARVRNATSRS RWWTSLREARRWWCAAPSGTRMTTAPTATPWKVTAPLGPTA LSWCTRRR (in Ref. 5; CAB61345).	cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGCTCCTTCCGGGACGAGGA	0.652													T	73733432	T	T	73733432	3	4	61	1	0	0	0	0	1	0	0	0	7897	643	23	2	2082	2	ITGB4	17	73733432	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08		73733432	7461778	43	4050											
BCL2	596	broad.mit.edu	37	chr18	60985794	60985796	+	In_Frame_Del	DEL	CCA	-	-													ggcccccgggggcgcggcgcCcacatctcccgcatcccact							TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr18:60985794_60985796delCCA	uc002lit.1	-	2	597_599	c.104_106delTGG	c.(103-108)GTGGGC>GGC	p.V35del	BCL2_uc002liu.1_In_Frame_Del_p.V35del|BCL2_uc002liv.1_In_Frame_Del_p.V35del	NM_000633	NP_000624	P10415	BCL2_HUMAN	B-cell lymphoma protein 2 alpha isoform	35		Cleavage; by caspase-3.			activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)	1		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	ggcgcggcgcccACATCTCCCGC	0.532			T	IGH@	NHL|CLL								-	60985796	-	-	60985794	7	5	61	1	0	1	0	1	0	0	0	0	1365	623	22	0	654	0	BCL2	18	60985794	In_Frame_Del	DEL	CCA	TCGA-06-0745-01A-01W-0348-08		60985794	17091454	44	4051											
C3	718	broad.mit.edu	37	chr19	6714208	6714208	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acctcaaactcagtggagaaGacctgctgtggtgagttttc	11	9	2	3			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr19:6714208G>C	uc002mfm.2	-	6	713	c.651C>G	c.(649-651)GTC>GTG	p.V217V		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	217					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CAGTGGAGAAGACCTGCTGTG	0.632													C	6714208	C	C	6714208	2	2	61	1	0	0	0	0	0	0	0	1	2204	929	33	5		5	C3	19	6714208	Silent	SNP	G	TCGA-06-0745-01A-01W-0348-08		6714208	52414775	45	4052											
MUC16	94025	broad.mit.edu	37	chr19	9072189	9072189	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctggtcacaggttccaagCgtgtacgtaatatgtctgta	11	8	2	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr19:9072189C>T	uc002mkp.2	-	3	15461	c.15257G>A	c.(15256-15258)CGC>CAC	p.R5086H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5088	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGTTCCAAGCGTGTACGTAA	0.433													T	9072189	T	T	9072189	3	4	61	1	0	0	0	0	1	0	0	0	9973	768	27	1	28594	1	MUC16	19	9072189	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08	2357981	9072189	50056794	46	4053											
ZNF844	284391	broad.mit.edu	37	chr19	12187210	12187210	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctatgaatgtaagcagtgtAgtaaagccttcatttcttcc	7	9	2	1	rs6511764	by1000genomes	TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr19:12187210A>G	uc002mtb.2	+	4	1418	c.1275A>G	c.(1273-1275)GTA>GTG	p.V425V	ZNF844_uc010dym.1_Silent_p.V268V	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAAGCAGTGTAGTAAAGCCTT	0.428													G	12187210	G	G	12187210	2	3	61	1	0	0	0	0	0	0	0	1	18187	407	15	4		4	ZNF844	19	12187210	Silent	SNP	A	TCGA-06-0745-01A-01W-0348-08	3115021	12187210	46941773	47	4054											
ZNF813	126017	broad.mit.edu	37	chr19	53995161	53995161	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgtaatgaatgtggcaagGtttttaatcaaaaagcacac	9	5	1	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr19:53995161G>A	uc002qbu.2	+	4	1803	c.1675G>A	c.(1675-1677)GTT>ATT	p.V559I	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	559	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		ATGTGGCAAGGTTTTTAATCA	0.363													A	53995161	A	A	53995161	3	1	61	1	0	0	0	0	1	0	0	0	18172	1261	44	3	1685	3	ZNF813	19	53995161	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08	41807951	53995161	5133822	48	4055											
SLC17A9	63910	broad.mit.edu	37	chr20	61596986	61596986	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggccttggcctctccagcGtctttgctctgtgcctgggc	13	14	3	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr20:61596986G>A	uc002yea.3	+	10	1154	c.970G>A	c.(970-972)GTC>ATC	p.V324I	SLC17A9_uc002ydz.3_Missense_Mutation_p.V318I|SLC17A9_uc011aap.1_Missense_Mutation_p.V344I	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	324	Helical; (Potential).				exocytosis|transmembrane transport	integral to membrane	transporter activity	p.V324I(1)		ovary(1)|skin(1)	2						CCTCTCCAGCGTCTTTGCTCT	0.652													A	61596986	A	A	61596986	3	1	61	1	0	0	0	0	1	0	0	0	14424	1145	40	1	1008	1	SLC17A9	20	61596986	Missense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08		61596986	1428534	49	4056											
RGL4	266747	broad.mit.edu	37	chr22	24040417	24040417	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aggaggtccgagttctgcagGaaatgcagctgctccaagtg	14	9	1	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr22:24040417G>T	uc002zxn.2	+	10	2449	c.1279G>T	c.(1279-1281)GAA>TAA	p.E427*	LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Nonsense_Mutation_p.E427*|RGL4_uc002zxp.1_Nonsense_Mutation_p.E291*|RGL4_uc002zxq.2_Nonsense_Mutation_p.E291*	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	427	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						AGTTCTGCAGGAAATGCAGCT	0.547													T	24040417	T	T	24040417	4	4	61	1	0	0	0	0	0	1	0	0	13279	1175	41	5	1317	5	RGL4	22	24040417	Nonsense_Mutation	SNP	G	TCGA-06-0745-01A-01W-0348-08		24040417	27264149	50	4057											
CHEK2	11200	broad.mit.edu	37	chr22	29130518	29130518	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agttcctgagtggacactgtCtctaaggagctcagtgtccc	11	11	2	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr22:29130518C>T	uc003adu.1	-	2	264	c.192G>A	c.(190-192)GAG>GAA	p.E64E	CHEK2_uc003ads.1_5'UTR|CHEK2_uc010gvh.1_Silent_p.E64E|CHEK2_uc010gvi.1_Silent_p.E64E|CHEK2_uc010gvj.1_RNA|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Silent_p.E64E|CHEK2_uc003adv.1_Silent_p.E64E|CHEK2_uc003adw.1_Silent_p.E64E|CHEK2_uc003adx.1_5'UTR|CHEK2_uc003ady.1_Silent_p.E64E|CHEK2_uc003adz.1_5'UTR	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	64			E -> K (in prostate cancer; somatic mutation).		cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						TGGACACTGTCTCTAAGGAGC	0.567			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				T	29130518	T	T	29130518	2	4	61	1	0	0	0	0	0	0	0	1	3335	912	32	3		3	CHEK2	22	29130518	Silent	SNP	C	TCGA-06-0745-01A-01W-0348-08	5090101	29130518	22174048	51	4058											
SBF1	6305	broad.mit.edu	37	chr22	50901747	50901747	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	catcatacggacgacaaagtCaaactgctggtggtccagga	11	10	2	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chr22:50901747C>G	uc003blh.2	-	16	2059	c.1864G>C	c.(1864-1866)GAC>CAC	p.D622H	SBF1_uc011arx.1_Missense_Mutation_p.D286H|SBF1_uc003bli.2_Missense_Mutation_p.D623H	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	622					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		ACGACAAAGTCAAACTGCTGG	0.632													G	50901747	G	G	50901747	3	3	61	1	0	0	0	0	1	0	0	0	13858	826	29	5	3921	5	SBF1	22	50901747	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08	21771229	50901747	402819	52	4059											
MXRA5	25878	broad.mit.edu	37	chrX	3239887	3239887	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cagttttcagagaaacagttCtaggcaaaagtatagtttct	8	6	3	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chrX:3239887C>T	uc004crg.3	-	5	3996	c.3839G>A	c.(3838-3840)AGA>AAA	p.R1280K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1280						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AGAAACAGTTCTAGGCAAAAG	0.408													T	3239887	T	T	3239887	3	4	61	1	0	0	0	0	1	0	0	0	10003	913	32	3	4659	3	MXRA5	23	3239887	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08		3239887	152030673	53	4060											
ZXDB	158586	broad.mit.edu	37	chrX	57619132	57619132	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccgcaagctgggttcccgcaTgccgcgcacccgggtgactg	14	16	0	1			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chrX:57619132T>A	uc004dvd.2	+	1	864	c.651T>A	c.(649-651)CAT>CAA	p.H217Q		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						GGTTCCCGCATGCCGCGCACC	0.736													A	57619132	A	A	57619132	3	1	61	1	0	0	0	0	1	0	0	0	18248	1461	51	5	653	5	ZXDB	23	57619132	Missense_Mutation	SNP	T	TCGA-06-0745-01A-01W-0348-08	54379245	57619132	97651428	54	4061											
CHM	1121	broad.mit.edu	37	chrX	85218739	85218739	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gagtaagtaattctgtttttCtttggttgctctgtggtatc	10	5	3	0			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chrX:85218739C>A	uc004eet.2	-	5	663	c.633G>T	c.(631-633)AAG>AAT	p.K211N	CHM_uc011mqz.1_Missense_Mutation_p.K63N	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	211					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				TTCTGTTTTTCTTTGGTTGCT	0.333													A	85218739	A	A	85218739	3	1	61	1	0	0	0	0	1	0	0	0	3350	912	32	5	1372	5	CHM	23	85218739	Missense_Mutation	SNP	C	TCGA-06-0745-01A-01W-0348-08	27599607	85218739	70051821	55	4062											
PCDH11X	27328	broad.mit.edu	37	chrX	91090731	91090731	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggagatgtgccactgattcgAattgaagaggatactggtga	14	5	0	5			TCGA-06-0745-01A-01W-0348-08	TCGA-06-0745-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	188c837e-6389-48eb-8b77-91c8a2f099ac	aead37c5-66ed-4ebd-9bb3-8086031213b8	g.chrX:91090731A>T	uc004efk.1	+	1	1073	c.228A>T	c.(226-228)CGA>CGT	p.R76R	PCDH11X_uc004efl.1_Silent_p.R76R|PCDH11X_uc004efo.1_Silent_p.R76R|PCDH11X_uc010nmv.1_Silent_p.R76R|PCDH11X_uc004efm.1_Silent_p.R76R|PCDH11X_uc004efn.1_Silent_p.R76R|PCDH11X_uc004efh.1_Silent_p.R76R|PCDH11X_uc004efj.1_Silent_p.R76R	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	76	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CACTGATTCGAATTGAAGAGG	0.443													T	91090731	T	T	91090731	2	4	61	1	0	0	0	0	0	0	0	1	11508	233	9	5		5	PCDH11X	23	91090731	Silent	SNP	A	TCGA-06-0745-01A-01W-0348-08	5871992	91090731	64179829	56	4063											
MTOR	2475	broad.mit.edu	37	chr1	11217231	11217231	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcccccaaggcctcgaggcAgcgcatgcggcccagcatca	11	17	1	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr1:11217231A>G	uc001asd.2	-	30	4568	c.4447T>C	c.(4447-4449)TGC>CGC	p.C1483R		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1483	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						GCCTCGAGGCAGCGCATGCGG	0.527													G	11217231	G	G	11217231	3	3	62	1	0	0	0	0	1	0	0	0	9954	188	7	4	3318	4	MTOR	1	11217231	Missense_Mutation	SNP	A	TCGA-06-0747-01A-01W-0348-08		11217231	238033390	1	4064											
KIF17	57576	broad.mit.edu	37	chr1	21031072	21031072	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcctgatgttcttggcccGgttggcgtagcgcagcgtgc	15	11	1	1	rs139912475		TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr1:21031072G>A	uc001bdr.3	-	5	1109	c.991C>T	c.(991-993)CGG>TGG	p.R331W	KIF17_uc001bds.3_Missense_Mutation_p.R331W	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	331					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TTCTTGGCCCGGTTGGCGTAG	0.597													A	21031072	A	A	21031072	3	1	62	1	0	0	0	0	1	0	0	0	8279	1115	39	2	2142	2	KIF17	1	21031072	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	9813841	21031072	228219549	2	4065											
ELTD1	64123	broad.mit.edu	37	chr1	79412033	79412033	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgaagccaggtacacacataCaataataacttccttctgtg	6	10	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr1:79412033C>G	uc001diq.3	-	3	407	c.251G>C	c.(250-252)TGT>TCT	p.C84S		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	84	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TACACACATACAATAATAACT	0.363													G	79412033	G	G	79412033	3	3	62	1	0	0	0	0	1	0	0	0	5084	478	17	5	1873	5	ELTD1	1	79412033	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	58380961	79412033	169838588	3	4066											
ABCA4	24	broad.mit.edu	37	chr1	94543367	94543367	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtagaggaagtttaggAtggcttcagcagtaatacct	11	7	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr1:94543367A>T	uc001dqh.2	-	11	1537	c.1433T>A	c.(1432-1434)ATC>AAC	p.I478N	ABCA4_uc010otn.1_Missense_Mutation_p.I478N	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	478	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GAAGTTTAGGATGGCTTCAGC	0.493													T	94543367	T	T	94543367	3	4	62	1	0	0	0	0	1	0	0	0	34	333	12	5	5548	5	ABCA4	1	94543367	Missense_Mutation	SNP	A	TCGA-06-0747-01A-01W-0348-08	15131334	94543367	154707254	4	4067											
ATP1A2	477	broad.mit.edu	37	chr1	160106156	160106156	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	atcagcatggcctacggacaGatcggtgcgccaagccccgg	13	14	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr1:160106156G>C	uc001fvc.2	+	18	2691	c.2559G>C	c.(2557-2559)CAG>CAC	p.Q853H	ATP1A2_uc001fvb.2_Missense_Mutation_p.Q853H|ATP1A2_uc001fvd.2_Missense_Mutation_p.Q589H	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	853	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CCTACGGACAGATCGGTGCGC	0.577													C	160106156	C	C	160106156	3	2	62	1	0	0	0	0	1	0	0	0	1129	933	33	5	2629	5	ATP1A2	1	160106156	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	65562789	160106156	89144465	5	4068											
DUSP27	92235	broad.mit.edu	37	chr1	167064116	167064116	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaaaggacacagaggaggaGcaggtagtcccaagcgagga	16	7	0	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr1:167064116G>A	uc001geb.1	+	1	30	c.30G>A	c.(28-30)GAG>GAA	p.E10E		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	10					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CAGAGGAGGAGCAGGTAGTCC	0.547													A	167064116	A	A	167064116	2	1	62	1	0	0	0	0	0	0	0	1	4824	962	34	3		3	DUSP27	1	167064116	Silent	SNP	G	TCGA-06-0747-01A-01W-0348-08	6957960	167064116	82186505	6	4069											
DUSP27	92235	broad.mit.edu	37	chr1	167095182	167095182	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggcttcctgaagcagctgCgggagctcaatgagaagttg	15	8	1	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr1:167095182C>T	uc001geb.1	+	5	814	c.814C>T	c.(814-816)CGG>TGG	p.R272W		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	272					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GAAGCAGCTGCGGGAGCTCAA	0.582													T	167095182	T	T	167095182	3	4	62	1	0	0	0	0	1	0	0	0	4824	759	27	1	832	1	DUSP27	1	167095182	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	31066	167095182	82155439	7	4070											
NLRP3	114548	broad.mit.edu	37	chr1	247587535	247587535	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tctatatccactgtcgagagGtgagccttgtgacacagagg	12	9	1	4			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr1:247587535G>T	uc001icr.2	+	5	928	c.790G>T	c.(790-792)GTG>TTG	p.V264L	NLRP3_uc001ics.2_Missense_Mutation_p.V264L|NLRP3_uc001icu.2_Missense_Mutation_p.V264L|NLRP3_uc001icw.2_Missense_Mutation_p.V264L|NLRP3_uc001icv.2_Missense_Mutation_p.V264L|NLRP3_uc010pyw.1_Missense_Mutation_p.V262L|NLRP3_uc001ict.1_Missense_Mutation_p.V262L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	264	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTGTCGAGAGGTGAGCCTTGT	0.537													T	247587535	T	T	247587535	3	4	62	1	0	0	0	0	1	0	0	0	10478	1261	44	5	800	5	NLRP3	1	247587535	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	80492353	247587535	1663086	8	4071											
SLC9A4	389015	broad.mit.edu	37	chr2	103095456	103095456	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtatctcctgccacccatcGttctggagggcggctacttc	10	14	2	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr2:103095456G>A	uc002tbz.3	+	2	872	c.415G>A	c.(415-417)GTT>ATT	p.V139I		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	139	Helical; Name=D/M4; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GCCACCCATCGTTCTGGAGGG	0.617													A	103095456	A	A	103095456	3	1	62	1	0	0	0	0	1	0	0	0	14716	1145	40	1	421	1	SLC9A4	2	103095456	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08		103095456	140103917	9	4072											
ANAPC1	64682	broad.mit.edu	37	chr2	112541977	112541977	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgttcataccactgagtgcCctttacaaatgtaaaagtcc	6	10	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr2:112541977C>T	uc002thi.2	-	41	5165	c.4918G>A	c.(4918-4920)GGC>AGC	p.G1640S		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1640					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						CACTGAGTGCCCTTTACAAAT	0.458													T	112541977	T	T	112541977	3	4	62	1	0	0	0	0	1	0	0	0	598	637	22	3	948	3	ANAPC1	2	112541977	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	9446521	112541977	130657396	10	4073											
TTN	7273	broad.mit.edu	37	chr2	179542530	179542530	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttcctcttcctcaggtagaActtcctcttcctcaggtaga	6	14	4	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr2:179542530A>G	uc010zfg.1	-	143	30601	c.30377T>C	c.(30376-30378)GTT>GCT	p.V10126A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V6787A|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11053							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCAGGTAGAACTTCCTCTTC	0.448													G	179542530	G	G	179542530	3	3	62	1	0	0	0	0	1	0	0	0	16732	43	2	4	70288	4	TTN	2	179542530	Missense_Mutation	SNP	A	TCGA-06-0747-01A-01W-0348-08	67000553	179542530	63656843	11	4074											
ALPI	248	broad.mit.edu	37	chr2	233323014	233323014	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgacgacgccattgagagggCgggccagctcaccagcgagg	16	13	1	1	rs146257849	byFrequency	TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr2:233323014C>T	uc002vst.3	+	9	1156	c.1079C>T	c.(1078-1080)GCG>GTG	p.A360V	ALPI_uc002vsu.3_Missense_Mutation_p.A271V	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	360					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		ATTGAGAGGGCGGGCCAGCTC	0.627													T	233323014	T	T	233323014	3	4	62	1	0	0	0	0	1	0	0	0	543	768	27	1	1113	1	ALPI	2	233323014	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	53780484	233323014	9876359	12	4075											
PDCD1	5133	broad.mit.edu	37	chr2	242800933	242800933	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctaagaaccatcctggccGccagcccagttgtagcaccg	9	16	0	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr2:242800933G>A	uc002wcq.3	-	1	126	c.58C>T	c.(58-60)CGG>TGG	p.R20W	PDCD1_uc010fzt.2_RNA	NM_005018	NP_005009	Q15116	PDCD1_HUMAN	programmed cell death 1 precursor	20					apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		CATCCTGGCCGCCAGCCCAGT	0.677													A	242800933	A	A	242800933	3	1	62	1	0	0	0	0	1	0	0	0	11615	1086	38	1	828	1	PDCD1	2	242800933	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	9477919	242800933	398440	13	4076											
ATP2B2	491	broad.mit.edu	37	chr3	10413514	10413514	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaatcttggtggtgtaggcGctgttgatggcgatggcatt	16	5	1	2	rs148841263	byFrequency	TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:10413514G>A	uc003bvt.2	-	12	2077	c.1638C>T	c.(1636-1638)AGC>AGT	p.S546S	ATP2B2_uc003bvv.2_Silent_p.S501S|ATP2B2_uc003bvw.2_Silent_p.S501S|ATP2B2_uc010hdo.2_Silent_p.S251S	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	546	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TGGTGTAGGCGCTGTTGATGG	0.547													A	10413514	A	A	10413514	2	1	62	1	0	0	0	0	0	0	0	1	1140	1078	38	1		1	ATP2B2	3	10413514	Silent	SNP	G	TCGA-06-0747-01A-01W-0348-08		10413514	187608916	14	4077											
NR2C2	7182	broad.mit.edu	37	chr3	15070193	15070193	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cggtgacacttcagaaatccAgccagaggaccagtctgcaa	10	12	2	3			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:15070193A>G	uc003bzj.3	+	8	1116	c.899A>G	c.(898-900)CAG>CGG	p.Q300R	NR2C2_uc003bzi.2_Missense_Mutation_p.Q319R	NM_003298	NP_003289	P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	300					cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						TCAGAAATCCAGCCAGAGGAC	0.542													G	15070193	G	G	15070193	3	3	62	1	0	0	0	0	1	0	0	0	10623	188	7	4	986	4	NR2C2	3	15070193	Missense_Mutation	SNP	A	TCGA-06-0747-01A-01W-0348-08	4656679	15070193	182952237	15	4078											
LRRC3B	116135	broad.mit.edu	37	chr3	26751737	26751737	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcaatgctgccaacgacGctgacctttgtaacctccct	6	16	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:26751737G>A	uc003cdp.2	+	2	1163	c.574G>A	c.(574-576)GCT>ACT	p.A192T	LRRC3B_uc003cdq.2_Missense_Mutation_p.A192T	NM_052953	NP_443185	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B precursor	192	LRRCT.					integral to membrane				pancreas(2)|ovary(1)|skin(1)	4						TGCCAACGACGCTGACCTTTG	0.468													A	26751737	A	A	26751737	3	1	62	1	0	0	0	0	1	0	0	0	8996	1087	38	1	576	1	LRRC3B	3	26751737	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	11681544	26751737	171270693	16	4079											
MST1R	4486	broad.mit.edu	37	chr3	49940194	49940194	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aactctggctcagtggcgctAagccgtgccaggcgtgtgtg	15	11	2	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:49940194A>G	uc003cxy.3	-	1	1113	c.849T>C	c.(847-849)CTT>CTC	p.L283L	MST1R_uc011bdd.1_Silent_p.L283L|MST1R_uc011bde.1_Silent_p.L283L|MST1R_uc011bdf.1_Silent_p.L283L|MST1R_uc011bdg.1_Silent_p.L283L	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	283	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CAGTGGCGCTAAGCCGTGCCA	0.622													G	49940194	G	G	49940194	2	3	62	1	0	0	0	0	0	0	0	1	9891	349	13	4		4	MST1R	3	49940194	Silent	SNP	A	TCGA-06-0747-01A-01W-0348-08	23188457	49940194	148082236	17	4080											
ITIH4	3700	broad.mit.edu	37	chr3	52851043	52851043	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atccatgagaacccagccttCtccctctcatactggccagt	6	16	2	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:52851043C>T	uc003dfz.2	-	21	2364	c.2328G>A	c.(2326-2328)GAG>GAA	p.E776E	ITIH4_uc011bel.1_Silent_p.E490E|ITIH4_uc003dfy.2_Silent_p.E571E|ITIH4_uc011bem.1_Silent_p.E781E|ITIH4_uc011ben.1_Silent_p.E746E	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	776					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		ACCCAGCCTTCTCCCTCTCAT	0.592													T	52851043	T	T	52851043	2	4	62	1	0	0	0	0	0	0	0	1	7906	912	32	3		3	ITIH4	3	52851043	Silent	SNP	C	TCGA-06-0747-01A-01W-0348-08	2910849	52851043	145171387	18	4081											
ARL6	84100	broad.mit.edu	37	chr3	97506846	97506846	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttttagatattaaacaccGtcgaattccaatcttattct	3	9	3	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:97506846G>A	uc003drv.2	+	7	675	c.362G>A	c.(361-363)CGT>CAT	p.R121H	ARL6_uc003drw.2_RNA|ARL6_uc003dru.2_Missense_Mutation_p.R121H|ARL6_uc010hoy.2_Missense_Mutation_p.R121H	NM_177976	NP_816931	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	121					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		ATTAAACACCGTCGAATTCCA	0.323									Bardet-Biedl_syndrome				A	97506846	A	A	97506846	3	1	62	1	0	0	0	0	1	0	0	0	941	1145	40	1	380	1	ARL6	3	97506846	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	44655803	97506846	100515584	19	4082											
OR5K1	26339	broad.mit.edu	37	chr3	98189167	98189167	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcccactttttgtcagtttcAttattctatggatctctttt	4	9	4	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:98189167A>G	uc003dsm.2	+	1	747	c.747A>G	c.(745-747)TCA>TCG	p.S249S		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						TGTCAGTTTCATTATTCTATG	0.333													G	98189167	G	G	98189167	2	3	62	1	0	0	0	0	0	0	0	1	11166	204	8	4		4	OR5K1	3	98189167	Silent	SNP	A	TCGA-06-0747-01A-01W-0348-08	682321	98189167	99833263	20	4083											
ST3GAL6	10402	broad.mit.edu	37	chr3	98507190	98507190	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aacactaatggtttttggaaGaaaccagccttaaacctgat	7	8	0	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:98507190G>C	uc003dsz.2	+	8	875	c.639G>C	c.(637-639)AAG>AAC	p.K213N	ST3GAL6_uc003dsy.2_Missense_Mutation_p.K127N|ST3GAL6_uc003dta.2_Missense_Mutation_p.K95N|ST3GAL6_uc003dtb.2_Missense_Mutation_p.K69N|ST3GAL6_uc003dtc.2_Missense_Mutation_p.K213N|ST3GAL6_uc010hpd.2_Missense_Mutation_p.K266N	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	213	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						GTTTTTGGAAGAAACCAGCCT	0.323													C	98507190	C	C	98507190	3	2	62	1	0	0	0	0	1	0	0	0	15218	933	33	5	665	5	ST3GAL6	3	98507190	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	318023	98507190	99515240	21	4084											
MYLK	4638	broad.mit.edu	37	chr3	123428617	123428617	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acagacctgacacttggacaGtcatagtgacctggcttcca	9	12	1	3			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:123428617G>C	uc003ego.2	-	14	2210	c.1928C>G	c.(1927-1929)ACT>AGT	p.T643S	MYLK_uc011bjw.1_Missense_Mutation_p.T643S|MYLK_uc003egp.2_Missense_Mutation_p.T574S|MYLK_uc003egq.2_Missense_Mutation_p.T643S|MYLK_uc003egr.2_Missense_Mutation_p.T574S|MYLK_uc003egs.2_Missense_Mutation_p.T467S	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	643	Ig-like C2-type 5.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CACTTGGACAGTCATAGTGAC	0.532													C	123428617	C	C	123428617	3	2	62	1	0	0	0	0	1	0	0	0	10056	1029	36	5	3900	5	MYLK	3	123428617	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	24921427	123428617	74593813	22	4085											
TRIM42	287015	broad.mit.edu	37	chr3	140397090	140397090	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatggaaactgctatgtgcGtttgctgtccatgttgtaca	10	9	0	0	rs116143762	by1000genomes	TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:140397090G>A	uc003eto.1	+	1	210	c.19G>A	c.(19-21)GTT>ATT	p.V7I		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	7	Cys-rich.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						TGCTATGTGCGTTTGCTGTCC	0.507													A	140397090	A	A	140397090	3	1	62	1	0	0	0	0	1	0	0	0	16514	1145	40	1	21	1	TRIM42	3	140397090	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	16968473	140397090	57625340	23	4086											
ZIC4	84107	broad.mit.edu	37	chr3	147114065	147114065	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctgcggcagctgccagggCgtcgctgcgggccgcaggcc	19	15	0	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:147114065C>T	uc003ewd.1	-	3	535	c.262G>A	c.(262-264)GCC>ACC	p.A88T	ZIC4_uc003ewc.1_Missense_Mutation_p.A18T|ZIC4_uc011bno.1_Missense_Mutation_p.A138T	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	88	Poly-Ala.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GCTGCCAGGGCGTCGCTGCGG	0.701													T	147114065	T	T	147114065	3	4	62	1	0	0	0	0	1	0	0	0	17678	768	27	1	754	1	ZIC4	3	147114065	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	6716975	147114065	50908365	24	4087											
VPS8	23355	broad.mit.edu	37	chr3	184571960	184571960	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgacttttccctatggccGggtgagtacgtccctccatc	10	13	0	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:184571960G>A	uc003fpb.1	+	12	1199	c.1028G>A	c.(1027-1029)CGG>CAG	p.R343Q	VPS8_uc010hyd.1_Missense_Mutation_p.R343Q	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	345							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			CCCTATGGCCGGGTGAGTACG	0.413													A	184571960	A	A	184571960	3	1	62	1	0	0	0	0	1	0	0	0	17215	1130	39	2	1076	2	VPS8	3	184571960	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	37457895	184571960	13450470	25	4088											
MUC4	4585	broad.mit.edu	37	chr3	195505849	195505849	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtggcgtgacctgtggatGctgaggaagtgtcggtgaca	19	6	0	3			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr3:195505849G>A	uc011bto.1	-	3	12678	c.12218C>T	c.(12217-12219)GCA>GTA	p.A4073V	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACCTGTGGATGCTGAGGAAGT	0.592													A	195505849	A	A	195505849	3	1	62	1	0	0	0	0	1	0	0	0	9978	1319	46	3		3	MUC4	3	195505849	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	10933889	195505849	2516581	26	4089											
TLR6	10333	broad.mit.edu	37	chr4	38830788	38830788	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atgagataaatccaaatattCtaaatcctggttgaacttga	6	6	1	3			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr4:38830788C>T	uc003gtm.2	-	1	373	c.307G>A	c.(307-309)GAA>AAA	p.E103K	TLR6_uc010ifg.1_Missense_Mutation_p.E103K	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	103	LRR 3.|Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						TCCAAATATTCTAAATCCTGG	0.363													T	38830788	T	T	38830788	3	4	62	1	0	0	0	0	1	0	0	0	15952	922	32	3	2087	3	TLR6	4	38830788	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08		38830788	152323488	27	4090											
PRDM8	56978	broad.mit.edu	37	chr4	81123201	81123201	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccaagacgaacaaggcggCggcgtgggcaccaaggacca	14	14	0	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr4:81123201C>T	uc010ijo.2	+	8	1424	c.585C>T	c.(583-585)GGC>GGT	p.G195G	PRDM8_uc003hmb.3_Silent_p.G195G|PRDM8_uc003hmc.3_Silent_p.G195G	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	195	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						AACAAggcggcggcgtgggca	0.343											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	81123201	T	T	81123201	2	4	62	1	0	0	0	0	0	0	0	1	12462	755	27	1		1	PRDM8	4	81123201	Silent	SNP	C	TCGA-06-0747-01A-01W-0348-08	42292413	81123201	110031075	28	4091											
HHIP	64399	broad.mit.edu	37	chr4	145580881	145580881	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtggggatggctcgcaacGtctcttcattctggaaaaag	12	8	3	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr4:145580881G>A	uc003ijs.1	+	4	1377	c.722G>A	c.(721-723)CGT>CAT	p.R241H	HHIP_uc003ijr.1_Missense_Mutation_p.R241H	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	241						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GGCTCGCAACGTCTCTTCATT	0.453													A	145580881	A	A	145580881	3	1	62	1	0	0	0	0	1	0	0	0	7092	1145	40	1	736	1	HHIP	4	145580881	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	64457680	145580881	45573395	29	4092											
HCN1	348980	broad.mit.edu	37	chr5	45262309	45262309	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggaaatcagagtggacaccTcatggggcagcgagggctgc	16	9	2	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr5:45262309T>A	uc003jok.2	-	8	2412	c.2387A>T	c.(2386-2388)GAG>GTG	p.E796V		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	796	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGTGGACACCTCATGGGGCAG	0.632													A	45262309	A	A	45262309	3	1	62	1	0	0	0	0	1	0	0	0	6996	1551	54	5	289	5	HCN1	5	45262309	Missense_Mutation	SNP	T	TCGA-06-0747-01A-01W-0348-08		45262309	135652951	30	4093											
PJA2	9867	broad.mit.edu	37	chr5	108680493	108680493	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggccacctcaacatccactgCaagagactctaaatgggcca	8	14	2	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr5:108680493C>A	uc003kos.3	-	8	2012	c.1792G>T	c.(1792-1794)GCA>TCA	p.A598S		NM_014819	NP_055634	O43164	PJA2_HUMAN	praja 2, RING-H2 motif containing	598	Interaction with PRKAR1A, PRKAR2A and PRKAR2B.				long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		ACATCCACTGCAAGAGACTCT	0.408													A	108680493	A	A	108680493	3	1	62	1	0	0	0	0	1	0	0	0	11962	710	25	5	346	5	PJA2	5	108680493	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	63418184	108680493	72234767	31	4094											
GNPDA1	10007	broad.mit.edu	37	chr5	141385836	141385838	+	In_Frame_Del	DEL	GAA	-	-													gggtggatgtcaatgtgcttGaagaagttgttccacatgaa							TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr5:141385836_141385838delGAA	uc003lmf.3	-	3	1039_1041	c.280_282delTTC	c.(280-282)TTCdel	p.F94del	GNPDA1_uc003lmg.3_In_Frame_Del_p.F94del|GNPDA1_uc010jgh.2_In_Frame_Del_p.F94del|GNPDA1_uc003lmh.3_In_Frame_Del_p.F60del	NM_005471	NP_005462	P46926	GNPI1_HUMAN	glucosamine-6-phosphate deaminase 1	94					generation of precursor metabolites and energy|glucosamine catabolic process|N-acetylglucosamine metabolic process|single fertilization	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity				0		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATGTGCTTGAAGAAGTTGTTC	0.527													-	141385838	-	-	141385836	7	5	62	1	0	1	0	1	0	0	0	0	6542	1281	45	0	603	0	GNPDA1	5	141385836	In_Frame_Del	DEL	GAA	TCGA-06-0747-01A-01W-0348-08	32705343	141385836	39529424	32	4095											
CPEB4	80315	broad.mit.edu	37	chr5	173317554	173317554	+	Frame_Shift_Del	DEL	A	-	-													tgcttttaaccagctgcctcAtttggcgaataatcttaaca							TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr5:173317554delA	uc003mcs.3	+	1	2224	c.818delA	c.(817-819)CATfs	p.H273fs	CPEB4_uc010jju.1_Frame_Shift_Del_p.H273fs|CPEB4_uc010jjv.2_Frame_Shift_Del_p.H273fs|CPEB4_uc011dfg.1_Frame_Shift_Del_p.H273fs|CPEB4_uc003mct.3_5'Flank|CPEB4_uc003mcu.3_5'Flank	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	273							nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CAGCTGCCTCATTTGGCGAAT	0.557													-	173317554	-	-	173317554	7	5	62	1	0	1	0	1	0	0	0	0	3803	217	8	0	820	0	CPEB4	5	173317554	Frame_Shift_Del	DEL	A	TCGA-06-0747-01A-01W-0348-08	31931718	173317554	7597706	33	4096											
PRSS16	10279	broad.mit.edu	37	chr6	27220721	27220721	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tatcagacatgtaccgagttCggcttctgtaagtgactggc	11	9	2	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr6:27220721C>T	uc003nja.2	+	9	1155	c.1143C>T	c.(1141-1143)TTC>TTT	p.F381F	PRSS16_uc011dkt.1_RNA|PRSS16_uc003njb.2_Silent_p.F124F|PRSS16_uc010jqq.1_Silent_p.F158F|PRSS16_uc010jqr.1_Silent_p.F132F|PRSS16_uc003njc.1_RNA|PRSS16_uc003njd.2_Intron	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	381					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						GTACCGAGTTCGGCTTCTGTA	0.507													T	27220721	T	T	27220721	2	4	62	1	0	0	0	0	0	0	0	1	12616	883	31	2		2	PRSS16	6	27220721	Silent	SNP	C	TCGA-06-0747-01A-01W-0348-08		27220721	143894346	34	4097											
UHRF1BP1	54887	broad.mit.edu	37	chr6	34838669	34838669	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcaactttgaagactggcCacatcaggccagctgtgggc	11	13	2	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr6:34838669C>T	uc003oju.3	+	18	3991	c.3757C>T	c.(3757-3759)CAC>TAC	p.H1253Y	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1253										ovary(3)	3						GAAGACTGGCCACATCAGGCC	0.428													T	34838669	T	T	34838669	3	4	62	1	0	0	0	0	1	0	0	0	16965	594	21	3	3827	3	UHRF1BP1	6	34838669	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	7617948	34838669	136276398	35	4098											
EEF1A1	1915	broad.mit.edu	37	chr6	74227627	74227627	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatgacacccaccgcaactGtctgtctcatatcacgaaca	6	14	3	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr6:74227627G>A	uc003phi.2	-	7	1332	c.1295C>T	c.(1294-1296)ACA>ATA	p.T432I	EEF1A1_uc003phd.2_Missense_Mutation_p.T157I|EEF1A1_uc003phe.2_Missense_Mutation_p.T422I|EEF1A1_uc003phf.2_Missense_Mutation_p.T425I|EEF1A1_uc003phg.2_3'UTR|EEF1A1_uc003phh.2_Missense_Mutation_p.T278I|EEF1A1_uc003phj.2_Missense_Mutation_p.T432I|EEF1A1_uc003phk.2_Missense_Mutation_p.T432I|EEF1A1_uc003phl.2_Intron|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	432						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						CACCGCAACTGTCTGTCTCAT	0.403											OREG0003893	type=REGULATORY REGION|Gene=BC038897|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	A	74227627	A	A	74227627	3	1	62	1	0	0	0	0	1	0	0	0	4923	1377	48	3	97	3	EEF1A1	6	74227627	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	39388958	74227627	96887440	36	4099											
TMEM30A	55754	broad.mit.edu	37	chr6	75968538	75968538	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tcggccagctggtaatgttgGatgtaaatcacttttccttt	9	8	1	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr6:75968538G>C	uc003phw.2	-	6	1128	c.850C>G	c.(850-852)CCA>GCA	p.P284A	TMEM30A_uc003phx.2_Missense_Mutation_p.P248A	NM_018247	NP_060717	Q9NV96	CC50A_HUMAN	transmembrane protein 30A isoform 1	284						integral to membrane					0						GGTAATGTTGGATGTAAATCA	0.388													C	75968538	C	C	75968538	3	2	62	1	0	0	0	0	1	0	0	0	16150	1174	41	5	243	5	TMEM30A	6	75968538	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	1740911	75968538	95146529	37	4100											
TTK	7272	broad.mit.edu	37	chr6	80746263	80746263	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgctaaagctaattgattttGggattgcaaaccaaatgcaa	8	6	0	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr6:80746263G>C	uc003pjc.2	+	17	2070	c.1996G>C	c.(1996-1998)GGG>CGG	p.G666R	TTK_uc003pjb.3_Missense_Mutation_p.G665R	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	666	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AATTGATTTTGGGATTGCAAA	0.323													C	80746263	C	C	80746263	3	2	62	1	0	0	0	0	1	0	0	0	16717	1348	47	5	2058	5	TTK	6	80746263	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	4777725	80746263	90368804	38	4101											
MYB	4602	broad.mit.edu	37	chr6	135514998	135514998	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccagtcatgttccataccCtgtagcgttacatgtaaata	6	11	1	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr6:135514998C>T	uc003qfc.2	+	7	984	c.785C>T	c.(784-786)CCT>CTT	p.P262L	MYB_uc003qfh.2_Missense_Mutation_p.P262L|MYB_uc003qfi.2_Missense_Mutation_p.P262L|MYB_uc010kgi.2_Missense_Mutation_p.P262L|MYB_uc003qfq.2_Missense_Mutation_p.P262L|MYB_uc010kgj.2_Missense_Mutation_p.P262L|MYB_uc003qfo.2_Missense_Mutation_p.P262L|MYB_uc003qfu.2_Missense_Mutation_p.P262L|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_5'UTR|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Missense_Mutation_p.P74L|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Missense_Mutation_p.P262L|MYB_uc003qgd.1_Missense_Mutation_p.P74L|MYB_uc003qge.1_5'Flank	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	262					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		GTTCCATACCCTGTAGCGTTA	0.453			T	NFIB	adenoid cystic carcinoma								T	135514998	T	T	135514998	3	4	62	1	0	0	0	0	1	0	0	0	10007	681	24	3	811	3	MYB	6	135514998	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	54768735	135514998	35600069	39	4102											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221823	+	Missense_Mutation	DNP	CC	TT	TT													gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc					rs149840192		TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr7:55221822_55221823CC>TT	uc003tqk.2	+	7	1112_1113	c.866_867CC>TT	c.(865-867)GCC>GTT	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTGA	0.594		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			TT	55221823	TT	TT	55221822	3	4	62	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	DNP	CC	TCGA-06-0747-01A-01W-0348-08		55221822	103916841	40	4103											
GPR85	54329	broad.mit.edu	37	chr7	112724771	112724771	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcagctgcatggctatagttCgccatagatggatggaggat	13	7	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr7:112724771C>T	uc010ljv.2	-	2	523	c.6G>A	c.(4-6)GCG>GCA	p.A2A	GPR85_uc003vgp.1_Silent_p.A2A|GPR85_uc003vgq.2_Silent_p.A2A|GPR85_uc010ljw.1_Silent_p.A2A	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	2	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						GGCTATAGTTCGCCATAGATG	0.403													T	112724771	T	T	112724771	2	4	62	1	0	0	0	0	0	0	0	1	6715	871	31	2		2	GPR85	7	112724771	Silent	SNP	C	TCGA-06-0747-01A-01W-0348-08	57502949	112724771	46413892	41	4104											
DENND2A	27147	broad.mit.edu	37	chr7	140267052	140267052	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcttcagccgggacttcacgTtgaccaggcgctggctgtga	14	12	2	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr7:140267052T>C	uc010lnj.2	-	7	1758	c.1613A>G	c.(1612-1614)AAC>AGC	p.N538S	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.N538S|DENND2A_uc003vvw.2_Missense_Mutation_p.N538S|DENND2A_uc003vvx.2_Missense_Mutation_p.N538S	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	538										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GGACTTCACGTTGACCAGGCG	0.383													C	140267052	C	C	140267052	3	2	62	1	0	0	0	0	1	0	0	0	4429	1725	60	4	1464	4	DENND2A	7	140267052	Missense_Mutation	SNP	T	TCGA-06-0747-01A-01W-0348-08	27542281	140267052	18871611	42	4105											
GBX1	2636	broad.mit.edu	37	chr7	150845924	150845924	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caagctcaggtatttcttgcAatgaaattccttctccaatt	5	10	3	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr7:150845924A>T	uc011kvg.1	-	2	1076	c.844T>A	c.(844-846)TGC>AGC	p.C282S		NM_001098834	NP_001092304	Q14549	GBX1_HUMAN	gastrulation brain homeo box 1	282	Homeobox.					nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TATTTCTTGCAATGAAATTCC	0.557													T	150845924	T	T	150845924	3	4	62	1	0	0	0	0	1	0	0	0	6280	130	5	5	250	5	GBX1	7	150845924	Missense_Mutation	SNP	A	TCGA-06-0747-01A-01W-0348-08	10578872	150845924	8292739	43	4106											
RPS20	6224	broad.mit.edu	37	chr8	56985787	56985787	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggaaacgatcccacgtcttAgaaccttcaccacaaggagt	8	12	2	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr8:56985787A>T	uc003xsn.2	-	4	420	c.222T>A	c.(220-222)TCT>TCA	p.S74S	RPS20_uc003xsm.2_Silent_p.S74S	NM_001023	NP_001014	P60866	RS20_HUMAN	ribosomal protein S20 isoform 2	74					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			CCCACGTCTTAGAACCTTCAC	0.388													T	56985787	T	T	56985787	2	4	62	1	0	0	0	0	0	0	0	1	13632	407	15	5		5	RPS20	8	56985787	Silent	SNP	A	TCGA-06-0747-01A-01W-0348-08		56985787	89378235	44	4107											
ARFGEF1	10565	broad.mit.edu	37	chr8	68140324	68140327	+	Frame_Shift_Del	DEL	TAAT	-	-													cttgggtgtgtcgtggaaagTaattcatccatagacacagc							TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr8:68140324_68140327delTAAT	uc003xxo.1	-	25	3852_3855	c.3462_3465delATTA	c.(3460-3465)GAATTAfs	p.E1154fs	ARFGEF1_uc003xxl.1_Frame_Shift_Del_p.E608fs|ARFGEF1_uc003xxn.1_Frame_Shift_Del_p.E137fs	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1154_1155					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCGTGGAAAGTAATTCATCCATAG	0.343													-	68140327	-	-	68140324	7	5	62	1	0	1	0	1	0	0	0	0	852	1635	57	0	2144	0	ARFGEF1	8	68140324	Frame_Shift_Del	DEL	TAAT	TCGA-06-0747-01A-01W-0348-08	11154537	68140324	78223698	45	4108											
EIF2C2	27161	broad.mit.edu	37	chr8	141570507	141570507	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcattttccagagagaaggCcggacggactgatggaagcc	13	9	1	3			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr8:141570507C>T	uc003yvn.2	-	5	661	c.621G>A	c.(619-621)CGG>CGA	p.R207R	EIF2C2_uc010men.2_Silent_p.R130R|EIF2C2_uc010meo.2_Silent_p.R207R	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	207					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			AGAGAGAAGGCCGGACGGACT	0.622													T	141570507	T	T	141570507	2	4	62	1	0	0	0	0	0	0	0	1	5006	726	26	3		3	EIF2C2	8	141570507	Silent	SNP	C	TCGA-06-0747-01A-01W-0348-08	73430183	141570507	4793515	46	4109											
IFNA10	3446	broad.mit.edu	37	chr9	21206995	21206995	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggagtatcaaggccctcctAttacccaggctgtgggtctg	12	11	2	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr9:21206995A>G	uc003zoq.1	-	1	148	c.102T>C	c.(100-102)AAT>AAC	p.N34N	IFNA14_uc003zoo.1_Intron	NM_002171	NP_002162	P01566	IFN10_HUMAN	interferon, alpha 10 precursor	34					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		AGGCCCTCCTATTACCCAGGC	0.512													G	21206995	G	G	21206995	2	3	62	1	0	0	0	0	0	0	0	1	7532	446	16	4		4	IFNA10	9	21206995	Silent	SNP	A	TCGA-06-0747-01A-01W-0348-08		21206995	120006436	47	4110											
KIAA0368	23392	broad.mit.edu	37	chr9	114188086	114188086	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actttgaatttgtatttgtaCcaaaaagtccatcatacacc	4	9	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr9:114188086C>T	uc004bfe.1	-	12	1607	c.1607G>A	c.(1606-1608)GGT>GAT	p.G536D	KIAA0368_uc010muc.1_Missense_Mutation_p.G358D	NM_001080398	NP_001073867			KIAA0368 protein												0						TGTATTTGTACCAAAAAGTCC	0.249													T	114188086	T	T	114188086	3	4	62	1	0	0	0	0	1	0	0	0	8171	507	18	3	4606	3	KIAA0368	9	114188086	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	92981091	114188086	27025345	48	4111											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123156840	123156840	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgctcagctgcaaaagcttcAtggtgttttgcaacttcttt	8	9	3	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr9:123156840A>C	uc004bkf.2	-	36	5709	c.5528T>G	c.(5527-5529)ATG>AGG	p.M1843R	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.M852R|CDK5RAP2_uc004bke.2_Missense_Mutation_p.M1128R|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.M1764R|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.M1108R|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.M1108R|CDK5RAP2_uc011lya.1_Missense_Mutation_p.M1108R|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.M1613R	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1843	Interaction with PCNT and AKAP9.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CAAAAGCTTCATGGTGTTTTG	0.423													C	123156840	C	C	123156840	3	2	62	1	0	0	0	0	1	0	0	0	3146	217	8	5	165	5	CDK5RAP2	9	123156840	Missense_Mutation	SNP	A	TCGA-06-0747-01A-01W-0348-08	8968754	123156840	18056591	49	4112											
OR1J1	347168	broad.mit.edu	37	chr9	125239745	125239745	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtatgcaaaagagcacacGcacaagcgatgacccaggac	12	11	0	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr9:125239745G>A	uc011lyu.1	-	1	461	c.461C>T	c.(460-462)GCG>GTG	p.A154V	OR1J2_uc004bmj.1_Intron	NM_001004451	NP_001004451	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						AAGAGCACACGCACAAGCGAT	0.542													A	125239745	A	A	125239745	3	1	62	1	0	0	0	0	1	0	0	0	10959	1087	38	1	510	1	OR1J1	9	125239745	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	2082905	125239745	15973686	50	4113											
MBL2	4153	broad.mit.edu	37	chr10	54531391	54531391	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gagggagtgatggaaacaggGacatggtcctcaccttggtg	16	7	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr10:54531391G>T	uc001jjt.2	-	1	70	c.5C>A	c.(4-6)TCC>TAC	p.S2Y		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	2					acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						TGGAAACAGGGACATGGTCCT	0.502													T	54531391	T	T	54531391	3	4	62	1	0	0	0	0	1	0	0	0	9350	1174	41	5	757	5	MBL2	10	54531391	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08		54531391	81003356	51	4114											
PCDH15	65217	broad.mit.edu	37	chr10	55839114	55839114	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atctggcctgccatctgaagCtgtgatgatcagaatgtagc	11	9	3	4			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr10:55839114C>G	uc001jju.1	-	17	2463	c.2068G>C	c.(2068-2070)GCT>CCT	p.A690P	PCDH15_uc010qhq.1_Missense_Mutation_p.A695P|PCDH15_uc010qhr.1_Missense_Mutation_p.A690P|PCDH15_uc010qhs.1_Missense_Mutation_p.A702P|PCDH15_uc010qht.1_Missense_Mutation_p.A697P|PCDH15_uc010qhu.1_Missense_Mutation_p.A690P|PCDH15_uc001jjv.1_Missense_Mutation_p.A668P|PCDH15_uc010qhv.1_Missense_Mutation_p.A690P|PCDH15_uc010qhw.1_Missense_Mutation_p.A653P|PCDH15_uc010qhx.1_Missense_Mutation_p.A619P|PCDH15_uc010qhy.1_Missense_Mutation_p.A695P|PCDH15_uc010qhz.1_Missense_Mutation_p.A690P|PCDH15_uc010qia.1_Missense_Mutation_p.A668P|PCDH15_uc010qib.1_Missense_Mutation_p.A668P|PCDH15_uc001jjw.2_Missense_Mutation_p.A690P	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	690	Cadherin 6.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CCATCTGAAGCTGTGATGATC	0.433										HNSCC(58;0.16)			G	55839114	G	G	55839114	3	3	62	1	0	0	0	0	1	0	0	0	11511	797	28	5	5486	5	PCDH15	10	55839114	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	1307723	55839114	79695633	52	4115											
MGMT	4255	broad.mit.edu	37	chr10	131506185	131506185	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaggtcccagcccccgctgCggttctcggaggtccggagc	16	15	1	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr10:131506185C>T	uc001lkh.2	+	3	271	c.245C>T	c.(244-246)GCG>GTG	p.A82V		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	51										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		GCCCCCGCTGCGGTTCTCGGA	0.602								Direct_reversal_of_damage					T	131506185	T	T	131506185	3	4	62	1	0	0	0	0	1	0	0	0	9557	768	27	1	255	1	MGMT	10	131506185	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	75667071	131506185	4028562	53	4116											
PDE3B	5140	broad.mit.edu	37	chr11	14853295	14853295	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgaacttgtagaaaagatggGagagaaatcaggaaggattc	13	3	1	4			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr11:14853295G>A	uc001mln.2	+	9	2419	c.2066G>A	c.(2065-2067)GGA>GAA	p.G689E	PDE3B_uc010rcr.1_Missense_Mutation_p.G638E	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	689					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						GAAAAGATGGGAGAGAAATCA	0.294													A	14853295	A	A	14853295	3	1	62	1	0	0	0	0	1	0	0	0	11638	1174	41	3	2100	3	PDE3B	11	14853295	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08		14853295	120153221	54	4117											
HIPK3	10114	broad.mit.edu	37	chr11	33375092	33375092	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccactgagtccaacaaaacTcagccagtatccatatatgt	5	12	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr11:33375092T>C	uc001mul.1	+	17	3896	c.3626T>C	c.(3625-3627)CTC>CCC	p.L1209P	HIPK3_uc001mum.1_Missense_Mutation_p.L1188P|HIPK3_uc009yjv.1_Missense_Mutation_p.L1188P	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	1209					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						CCAACAAAACTCAGCCAGTAT	0.363													C	33375092	C	C	33375092	3	2	62	1	0	0	0	0	1	0	0	0	7118	1551	54	4	3688	4	HIPK3	11	33375092	Missense_Mutation	SNP	T	TCGA-06-0747-01A-01W-0348-08	18521797	33375092	101631424	55	4118											
OR5AS1	219447	broad.mit.edu	37	chr11	55798090	55798090	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtattattttcttagcaacTtatctttcttagacatcagc	4	8	4	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr11:55798090T>G	uc010riw.1	+	1	196	c.196T>G	c.(196-198)TTA>GTA	p.L66V		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TCTTAGCAACTTATCTTTCTT	0.348													G	55798090	G	G	55798090	3	3	62	1	0	0	0	0	1	0	0	0	11146	1606	56	5	198	5	OR5AS1	11	55798090	Missense_Mutation	SNP	T	TCGA-06-0747-01A-01W-0348-08	22422998	55798090	79208426	56	4119											
OR5M9	390162	broad.mit.edu	37	chr11	56229973	56229973	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcacatatgtcttggtgattGctttgttgactgcttctttt	8	7	3	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr11:56229973G>C	uc010rjj.1	-	1	905	c.905C>G	c.(904-906)GCA>GGA	p.A302G		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CTTGGTGATTGCTTTGTTGAC	0.378													C	56229973	C	C	56229973	3	2	62	1	0	0	0	0	1	0	0	0	11177	1319	46	5	29	5	OR5M9	11	56229973	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	431883	56229973	78776543	57	4120											
DTX4	23220	broad.mit.edu	37	chr11	58949878	58949878	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtggccctggccaccttgaAtcgtaccaacctgcagcgac	11	15	0	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr11:58949878A>G	uc001nns.2	+	2	1135	c.878A>G	c.(877-879)AAT>AGT	p.N293S	DTX4_uc001nnr.2_Missense_Mutation_p.N187S	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	293					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				GCCACCTTGAATCGTACCAAC	0.612													G	58949878	G	G	58949878	3	3	62	1	0	0	0	0	1	0	0	0	4797	101	4	4	884	4	DTX4	11	58949878	Missense_Mutation	SNP	A	TCGA-06-0747-01A-01W-0348-08	2719905	58949878	76056638	58	4121											
PCNXL3	399909	broad.mit.edu	37	chr11	65402835	65402835	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacacgccctccctgctggcGctgcgccatgtcctggatga	11	16	0	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr11:65402835G>A	uc001oey.2	+	31	5100	c.5100G>A	c.(5098-5100)GCG>GCA	p.A1700A	PCNXL3_uc001oez.2_Silent_p.A587A	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1700						integral to membrane					0						CCCTGCTGGCGCTGCGCCATG	0.632													A	65402835	A	A	65402835	2	1	62	1	0	0	0	0	0	0	0	1	11593	1074	38	1		1	PCNXL3	11	65402835	Silent	SNP	G	TCGA-06-0747-01A-01W-0348-08	6452957	65402835	69603681	59	4122											
CACNA1C	775	broad.mit.edu	37	chr12	2716205	2716205	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accaccccatcatccaacccCgcagctgggagaacagcaag	8	17	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr12:2716205C>T	uc009zdu.1	+	27	3638	c.3325C>T	c.(3325-3327)CGC>TGC	p.R1109C	CACNA1C_uc009zdv.1_Missense_Mutation_p.R1086C|CACNA1C_uc001qkb.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qkc.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qke.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qkf.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qjz.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qkd.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qkg.2_Missense_Mutation_p.R1089C|CACNA1C_uc009zdw.1_Missense_Mutation_p.R1089C|CACNA1C_uc001qkh.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qkl.2_Missense_Mutation_p.R1109C|CACNA1C_uc001qkn.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qko.2_Missense_Mutation_p.R1109C|CACNA1C_uc001qkp.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qkr.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qku.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qkq.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qks.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qkt.2_Missense_Mutation_p.R1089C|CACNA1C_uc001qka.1_Missense_Mutation_p.R624C|CACNA1C_uc001qki.1_Missense_Mutation_p.R825C|CACNA1C_uc001qkj.1_Missense_Mutation_p.R825C|CACNA1C_uc001qkk.1_Missense_Mutation_p.R825C|CACNA1C_uc001qkm.1_Missense_Mutation_p.R825C	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1109	Extracellular (Potential).|III.|Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CATCCAACCCCGCAGCTGGGA	0.542													T	2716205	T	T	2716205	3	4	62	1	0	0	0	0	1	0	0	0	2540	652	23	2	3539	2	CACNA1C	12	2716205	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08		2716205	131135690	60	4123											
TMTC1	83857	broad.mit.edu	37	chr12	29669420	29669420	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcacggccaaaacctgagcCtacaaaaccacatggacctt	6	14	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr12:29669420C>A	uc001rjb.2	-	15	2320	c.1846_splice	c.e15-1	p.A616_splice	TMTC1_uc001riz.2_Splice_Site_p.A373_splice|TMTC1_uc001rja.2_Splice_Site_p.A460_splice|TMTC1_uc001riy.2_Splice_Site_p.A69_splice	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat							integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					AAACCTGAGCCTACAAAACCA	0.453													A	29669420	A	A	29669420	5	1	62	1	0	0	0	0	0	0	1	0	16257	695	24	5	495	5	TMTC1	12	29669420	Splice_Site	SNP	C	TCGA-06-0747-01A-01W-0348-08	26953215	29669420	104182475	61	4124											
ABCD2	225	broad.mit.edu	37	chr12	40001468	40001468	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtaaatttcgagcagtgGtaaaggcttctgtccgttca	10	9	2	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr12:40001468G>A	uc001rmb.2	-	3	1595	c.1169C>T	c.(1168-1170)ACC>ATC	p.T390I		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	390	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						TCGAGCAGTGGTAAAGGCTTC	0.323													A	40001468	A	A	40001468	3	1	62	1	0	0	0	0	1	0	0	0	61	1261	44	3	1085	3	ABCD2	12	40001468	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	10332048	40001468	93850427	62	4125											
PCDH20	64881	broad.mit.edu	37	chr13	61985826	61985826	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctcttccaaagtaatgttGccagttttagggtcaatcct	8	10	2	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr13:61985826G>A	uc001vid.3	-	2	2770	c.2406C>T	c.(2404-2406)GGC>GGT	p.G802G	PCDH20_uc010thj.1_Silent_p.G802G	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	775	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		AAGTAATGTTGCCAGTTTTAG	0.488													A	61985826	A	A	61985826	2	1	62	1	0	0	0	0	0	0	0	1	11515	1306	46	3		3	PCDH20	13	61985826	Silent	SNP	G	TCGA-06-0747-01A-01W-0348-08		61985826	53184052	63	4126											
PCID2	55795	broad.mit.edu	37	chr13	113854813	113854813	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagatgctccatctctgctGtcgatggcttcgtacacctg	9	13	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr13:113854813G>A	uc010tju.1	-	2	135	c.54C>T	c.(52-54)GAC>GAT	p.D18D	PCID2_uc010tjv.1_Silent_p.D18D|PCID2_uc010tjw.1_Silent_p.D18D|PCID2_uc001vte.2_5'UTR|PCID2_uc001vtd.2_5'UTR|PCID2_uc001vtf.2_5'UTR|PCID2_uc001vtg.1_RNA	NM_001127203	NP_001120675	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	18					negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			CATCTCTGCTGTCGATGGCTT	0.418													A	113854813	A	A	113854813	2	1	62	1	0	0	0	0	0	0	0	1	11579	1368	48	3		3	PCID2	13	113854813	Silent	SNP	G	TCGA-06-0747-01A-01W-0348-08	51868987	113854813	1315065	64	4127											
AHNAK2	113146	broad.mit.edu	37	chr14	105404844	105404844	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaacccaatgtttggaagCcaaaaccagagcagaccaga	9	10	0	3			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr14:105404844C>T	uc010axc.1	-	7	17064	c.16944G>A	c.(16942-16944)TGG>TGA	p.W5648*	AHNAK2_uc001ypx.2_Nonsense_Mutation_p.W5548*	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5648						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGTTTGGAAGCCAAAACCAGA	0.478													T	105404844	T	T	105404844	4	4	62	1	0	0	0	0	0	1	0	0	415	740	26	3	447	3	AHNAK2	14	105404844	Nonsense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08		105404844	1944696	65	4128											
EIF3J	8669	broad.mit.edu	37	chr15	44829531	44829532	+	Frame_Shift_Ins	INS	-	T	T													tcttccgtagacgccgacgcINStttctccgtggaagacccag							TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr15:44829531_44829532insT	uc001ztv.2	+	2	180_181	c.53_54insT	c.(52-54)GCTfs	p.A18fs	uc001ztu.2_5'Flank|EIF3J_uc010ueg.1_Frame_Shift_Ins_p.A18fs|EIF3J_uc001ztw.2_Frame_Shift_Ins_p.A18fs	NM_003758	NP_003749	O75822	EIF3J_HUMAN	eukaryotic translation initiation factor 3,	18	Sufficient for interaction with EIF3B.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity				0		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)		GACGCCGACGCTTTCTCCGTGG	0.594													T	44829532	T	T	44829531	7	5	62	1	0	1	1	0	0	0	0	0	5020	797	28	0	59	0	EIF3J	15	44829531	Frame_Shift_Ins	INS	-	TCGA-06-0747-01A-01W-0348-08		44829531	57701861	66	4129											
CEP152	22995	broad.mit.edu	37	chr15	49054660	49054660	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcatagcccccttgatggcTatgtccttctcttgttctaa	6	12	3	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr15:49054660T>G	uc001zwy.2	-	18	2524	c.2490A>C	c.(2488-2490)ATA>ATC	p.I830I	CEP152_uc001zwz.2_Silent_p.I830I|CEP152_uc001zxa.1_Silent_p.I737I	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	830					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CCTTGATGGCTATGTCCTTCT	0.358													G	49054660	G	G	49054660	2	3	62	1	0	0	0	0	0	0	0	1	3248	1512	53	5		5	CEP152	15	49054660	Silent	SNP	T	TCGA-06-0747-01A-01W-0348-08	4225129	49054660	53476732	67	4130											
HYDIN	54768	broad.mit.edu	37	chr16	70913364	70913364	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaccagcgatgtcaaacaCgaggcctcggctcttggcca	10	15	3	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr16:70913364C>T	uc002ezr.2	-	62	10518	c.10390G>A	c.(10390-10392)GTG>ATG	p.V3464M		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3465										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ATGTCAAACACGAGGCCTCGG	0.567													T	70913364	T	T	70913364	3	4	62	1	0	0	0	0	1	0	0	0	7467	536	19	1	5072	1	HYDIN	16	70913364	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08		70913364	19441389	68	4131											
SLC4A1	6521	broad.mit.edu	37	chr17	42330498	42330498	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcactcacccacaagcacagCgaccaggagtccactgatcc	7	17	2	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr17:42330498C>T	uc002igf.3	-	17	2448	c.2299G>A	c.(2299-2301)GCT>ACT	p.A767T		NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	767	Helical; (Potential).|Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		ACAAGCACAGCGACCAGGAGT	0.637													T	42330498	T	T	42330498	3	4	62	1	0	0	0	0	1	0	0	0	14650	768	27	1	452	1	SLC4A1	17	42330498	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08		42330498	38864712	69	4132											
FBF1	85302	broad.mit.edu	37	chr17	73914257	73914257	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acataccgcgtgtgggaggtGgcactggtggccgcatcgac	16	11	0	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr17:73914257G>A	uc002jqc.2	-	20	2461	c.2187C>T	c.(2185-2187)GCC>GCT	p.A729A	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Silent_p.A720A|FBF1_uc002jqd.1_Silent_p.A730A|FBF1_uc002jqb.2_RNA|FBF1_uc010dgr.1_Silent_p.A40A	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	729											0						TGTGGGAGGTGGCACTGGTGG	0.662													A	73914257	A	A	73914257	2	1	62	1	0	0	0	0	0	0	0	1	5695	1335	47	3		3	FBF1	17	73914257	Silent	SNP	G	TCGA-06-0747-01A-01W-0348-08	31583759	73914257	7280953	70	4133											
AANAT	15	broad.mit.edu	37	chr17	74465812	74465812	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtgctggccgtgcaccgCgccttccggcagcagggcag	15	15	0	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr17:74465812C>T	uc002jro.2	+	4	618	c.384C>T	c.(382-384)CGC>CGT	p.R128R	AANAT_uc010wte.1_RNA	NM_001088	NP_001079	Q16613	SNAT_HUMAN	arylalkylamine N-acetyltransferase	128	N-acetyltransferase.				circadian rhythm|melatonin biosynthetic process	cytosol	aralkylamine N-acetyltransferase activity				0						CCGTGCACCGCGCCTTCCGGC	0.701													T	74465812	T	T	74465812	2	4	62	1	0	0	0	0	0	0	0	1	18	755	27	1		1	AANAT	17	74465812	Silent	SNP	C	TCGA-06-0747-01A-01W-0348-08	551555	74465812	6729398	71	4134											
EPB41L3	23136	broad.mit.edu	37	chr18	5489008	5489008	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctgggctcacctccctccGcaccggggtgctgtgcgctg	14	17	1	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr18:5489008G>A	uc002kmt.1	-	2	261	c.175C>T	c.(175-177)CGG>TGG	p.R59W	EPB41L3_uc010wzh.1_Missense_Mutation_p.R59W|EPB41L3_uc002kmu.1_Missense_Mutation_p.R59W|EPB41L3_uc010dkq.1_5'UTR|EPB41L3_uc010dks.1_Missense_Mutation_p.R81W|EPB41L3_uc002kmv.1_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	59					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						ACCTCCCTCCGCACCGGGGTG	0.562													A	5489008	A	A	5489008	3	1	62	1	0	0	0	0	1	0	0	0	5154	1086	38	1	3172	1	EPB41L3	18	5489008	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08		5489008	72588240	72	4135											
LAMA3	3909	broad.mit.edu	37	chr18	21338466	21338466	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgcttgggagcagagccacGagtgtgaaggtgggtgtggg	20	7	0	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr18:21338466G>A	uc002kuq.2	+	7	1140	c.1054G>A	c.(1054-1056)GAG>AAG	p.E352K	LAMA3_uc010dlv.1_Missense_Mutation_p.E352K|LAMA3_uc002kur.2_Missense_Mutation_p.E352K	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	352	Laminin EGF-like 1.|Domain V.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCAGAGCCACGAGTGTGAAGG	0.647													A	21338466	A	A	21338466	3	1	62	1	0	0	0	0	1	0	0	0	8607	1059	37	2	1080	2	LAMA3	18	21338466	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	15849458	21338466	56738782	73	4136											
TAF4B	6875	broad.mit.edu	37	chr18	23873445	23873445	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaattctgtcacttcaagcAtctcctactcagaaaaatag	4	10	5	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr18:23873445A>G	uc002kvu.3	+	9	2271	c.1782A>G	c.(1780-1782)GCA>GCG	p.A594A	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Silent_p.A599A	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	594					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			CACTTCAAGCATCTCCTACTC	0.269													G	23873445	G	G	23873445	2	3	62	1	0	0	0	0	0	0	0	1	15524	204	8	4		4	TAF4B	18	23873445	Silent	SNP	A	TCGA-06-0747-01A-01W-0348-08	2534979	23873445	54203803	74	4137											
BEST2	54831	broad.mit.edu	37	chr19	12864093	12864093	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctttgtgctgaccgaagggCagaagcgctacttcgagaag	14	9	0	3			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr19:12864093C>T	uc002mux.2	+	2	172	c.172C>T	c.(172-174)CAG>TAG	p.Q58*		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	58	Extracellular (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						GACCGAAGGGCAGAAGCGCTA	0.567													T	12864093	T	T	12864093	4	4	62	1	0	0	0	0	0	1	0	0	1405	711	25	3	178	3	BEST2	19	12864093	Nonsense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08		12864093	46264890	75	4138											
OR7A10	390892	broad.mit.edu	37	chr19	14951796	14951796	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagaatgttttcatagcaccCtttatgtgtttattcctcag	6	8	2	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr19:14951796C>A	uc002mzx.1	-	1	894	c.894G>T	c.(892-894)AAG>AAT	p.K298N		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					TCATAGCACCCTTTATGTGTT	0.468													A	14951796	A	A	14951796	3	1	62	1	0	0	0	0	1	0	0	0	11214	680	24	5	39	5	OR7A10	19	14951796	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	2087703	14951796	44177187	76	4139											
MAP1S	55201	broad.mit.edu	37	chr19	17838511	17838511	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtgcccggtcacaggaacGggcaggtgggctgggggccg	20	11	1	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr19:17838511G>A	uc002nhe.1	+	5	2327	c.2318G>A	c.(2317-2319)CGG>CAG	p.R773Q	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_Missense_Mutation_p.R21Q|MAP1S_uc010xpv.1_Missense_Mutation_p.R747Q	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	773	Pro-rich.|Necessary for the microtubule-organizing center localization.|Necessary for association with microtubules.|Necessary for interaction with RASSF1 isoform A and isoform C.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						TCACAGGAACGGGCAGGTGGG	0.687													A	17838511	A	A	17838511	3	1	62	1	0	0	0	0	1	0	0	0	9234	1116	39	2	2336	2	MAP1S	19	17838511	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	2886715	17838511	41290472	77	4140											
CEACAM5	1048	broad.mit.edu	37	chr19	42218934	42218934	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagcaacaactccaaacccGtggaggacaaggatgctgtg	11	12	0	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr19:42218934G>A	uc002ork.2	+	3	590	c.469G>A	c.(469-471)GTG>ATG	p.V157M	CEACAM5_uc010ehz.1_Missense_Mutation_p.V157M|CEACAM5_uc002orj.1_Missense_Mutation_p.V157M|CEACAM5_uc002orl.2_Missense_Mutation_p.V157M	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	157	Ig-like 2.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CTCCAAACCCGTGGAGGACAA	0.562													A	42218934	A	A	42218934	3	1	62	1	0	0	0	0	1	0	0	0	3195	1145	40	1	479	1	CEACAM5	19	42218934	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	24380423	42218934	16910049	78	4141											
FUT1	2523	broad.mit.edu	37	chr19	49253828	49253828	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccggaggtaggcgctgtcGcccaccacacccttccagcg	12	17	0	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr19:49253828G>A	uc002pkk.2	-	4	1686	c.711C>T	c.(709-711)GGC>GGT	p.G237G		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	237	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		AGGCGCTGTCGCCCACCACAC	0.657													A	49253828	A	A	49253828	2	1	62	1	0	0	0	0	0	0	0	1	6101	1074	38	1		1	FUT1	19	49253828	Silent	SNP	G	TCGA-06-0747-01A-01W-0348-08	7034894	49253828	9875155	79	4142											
NLRP12	91662	broad.mit.edu	37	chr19	54314476	54314476	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttgacacattcccctaggCgcgcattgcggtcttccatg	11	13	1	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr19:54314476C>T	uc002qch.3	-	3	657	c.437G>A	c.(436-438)CGC>CAC	p.R146H	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.R146H|NLRP12_uc002qcj.3_Missense_Mutation_p.R146H|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.R146H	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	146					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TTCCCCTAGGCGCGCATTGCG	0.567													T	54314476	T	T	54314476	3	4	62	1	0	0	0	0	1	0	0	0	10474	768	27	1	2876	1	NLRP12	19	54314476	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	5060648	54314476	4814507	80	4143											
SAPS1	22870	broad.mit.edu	37	chr19	55742009	55742009	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggggatgcaggcccttccgGggcagagccattgggtatcg	17	10	0	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr19:55742009G>T	uc002qjw.3	-	23	2856	c.2614C>A	c.(2614-2616)CCG>ACG	p.P872T	TMEM86B_uc002qjt.2_5'Flank|TMEM86B_uc002qju.2_5'Flank|SAPS1_uc002qjv.2_Missense_Mutation_p.P934T	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	872	Pro-rich.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		GGCCCTTCCGGGGCAGAGCCA	0.677													T	55742009	T	T	55742009	3	4	62	1	0	0	0	0	1	0	0	0	13836	1232	43	5	39	5	SAPS1	19	55742009	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	1427533	55742009	3386974	81	4144											
C20orf196	149840	broad.mit.edu	37	chr20	5843987	5843987	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tcttacagaggcattccaggGacacccacttctacccactg	7	15	2	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr20:5843987G>T	uc002wmf.2	+	3	583	c.496G>T	c.(496-498)GAC>TAC	p.D166Y		NM_152504	NP_689717	Q8IYI0	CT196_HUMAN	hypothetical protein LOC149840	166											0						GCATTCCAGGGACACCCACTT	0.512													T	5843987	T	T	5843987	3	4	62	1	0	0	0	0	1	0	0	0	2101	1174	41	5	502	5	C20orf196	20	5843987	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08		5843987	57181533	82	4145											
DLGAP4	22839	broad.mit.edu	37	chr20	35060659	35060659	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catggaggacggcaagggccGgagggccaaaagcaaggagc	18	9	0	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr20:35060659G>A	uc002xff.2	+	3	974	c.539G>A	c.(538-540)CGG>CAG	p.R180Q	DLGAP4_uc010zvp.1_Missense_Mutation_p.R180Q	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	180					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GGCAAGGGCCGGAGGGCCAAA	0.647													A	35060659	A	A	35060659	3	1	62	1	0	0	0	0	1	0	0	0	4562	1116	39	2	541	2	DLGAP4	20	35060659	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	29216672	35060659	27964861	83	4146											
NFATC2	4773	broad.mit.edu	37	chr20	50133367	50133367	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagctttgacagcccctcGgctgccttctgtctcatagt	10	13	2	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr20:50133367G>A	uc002xwd.2	-	3	1508	c.1288C>T	c.(1288-1290)CGA>TGA	p.R430*	NFATC2_uc002xwc.2_Nonsense_Mutation_p.R430*|NFATC2_uc010zyv.1_Nonsense_Mutation_p.R211*|NFATC2_uc010zyw.1_Nonsense_Mutation_p.R211*|NFATC2_uc010zyx.1_Nonsense_Mutation_p.R410*|NFATC2_uc010zyy.1_Nonsense_Mutation_p.R211*|NFATC2_uc010zyz.1_Nonsense_Mutation_p.R211*|NFATC2_uc002xwe.2_Nonsense_Mutation_p.R410*	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	430	RHD.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					ACAGCCCCTCGGCTGCCTTCT	0.557													A	50133367	A	A	50133367	4	1	62	1	0	0	0	0	0	1	0	0	10362	1124	39	2	1569	2	NFATC2	20	50133367	Nonsense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	15072708	50133367	12892153	84	4147											
COL20A1	57642	broad.mit.edu	37	chr20	61943349	61943349	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttctgggagggtgccccgaGgcctgtgcgcctggtcaggg	19	11	2	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr20:61943349G>A	uc011aau.1	+	14	1845	c.1745G>A	c.(1744-1746)AGG>AAG	p.R582K	COL20A1_uc011aav.1_Missense_Mutation_p.R403K	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	582	Fibronectin type-III 4.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					GGTGCCCCGAGGCCTGTGCGC	0.682													A	61943349	A	A	61943349	3	1	62	1	0	0	0	0	1	0	0	0	3679	1000	35	3	1795	3	COL20A1	20	61943349	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08	11809982	61943349	1082171	85	4148											
KRTAP10-11	386678	broad.mit.edu	37	chr21	46066409	46066409	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatgtctgtctgctccagcGcttactccgactcctggcag	9	16	2	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr21:46066409G>A	uc002zfr.3	+	1	79	c.34G>A	c.(34-36)GCT>ACT	p.A12T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	12						keratin filament				ovary(1)	1						CTGCTCCAGCGCTTACTCCGA	0.582													A	46066409	A	A	46066409	3	1	62	1	0	0	0	0	1	0	0	0	8507	1087	38	1	36	1	KRTAP10-11	21	46066409	Missense_Mutation	SNP	G	TCGA-06-0747-01A-01W-0348-08		46066409	2063486	86	4149											
SLC19A1	6573	broad.mit.edu	37	chr21	46950811	46950811	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccgcctgcgtggccgtgaCgcccgcgatgagcagcttgg	15	16	0	2	rs142899279		TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr21:46950811C>T	uc002zhl.1	-	4	1143	c.1024G>A	c.(1024-1026)GTC>ATC	p.V342I	SLC19A1_uc010gpy.1_Missense_Mutation_p.V342I|SLC19A1_uc011aft.1_Missense_Mutation_p.V302I|SLC19A1_uc002zhm.1_Missense_Mutation_p.V342I|SLC19A1_uc010gpz.1_Missense_Mutation_p.V221I	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	342	Helical; (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GTGGCCGTGACGCCCGCGATG	0.697													T	46950811	T	T	46950811	3	4	62	1	0	0	0	0	1	0	0	0	14428	536	19	1	763	1	SLC19A1	21	46950811	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	884402	46950811	1179084	87	4150											
CCT8L2	150160	broad.mit.edu	37	chr22	17073274	17073274	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtcaccaggaacttctgcCggccgtgggggccatagcaa	14	12	2	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr22:17073274C>T	uc002zlp.1	-	1	427	c.167G>A	c.(166-168)CGG>CAG	p.R56Q		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	56					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GAACTTCTGCCGGCCGTGGGG	0.642													T	17073274	T	T	17073274	3	4	62	1	0	0	0	0	1	0	0	0	2961	652	23	2	1510	2	CCT8L2	22	17073274	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08		17073274	34231292	88	4151											
GNB1L	54584	broad.mit.edu	37	chr22	19799872	19799872	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccccggccaggatgctgCtccggcagaagcccacactc	12	18	0	1			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr22:19799872C>T	uc002zqe.1	-	4	747	c.353G>A	c.(352-354)AGC>AAC	p.S118N	GNB1L_uc002zqd.1_5'UTR|GNB1L_uc002zqf.1_Missense_Mutation_p.S118N	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	118					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					CAGGATGCTGCTCCGGCAGAA	0.692													T	19799872	T	T	19799872	3	4	62	1	0	0	0	0	1	0	0	0	6516	797	28	3	646	3	GNB1L	22	19799872	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	2726598	19799872	31504694	89	4152											
BPIL2	254240	broad.mit.edu	37	chr22	32833790	32833790	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcagtaatttctggagaaCtgattagggagtaatccagc	10	7	2	2			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr22:32833790C>T	uc003amn.2	-	7	704	c.704G>A	c.(703-705)AGT>AAT	p.S235N	BPIL2_uc010gwo.2_Missense_Mutation_p.S49N|BPIL2_uc011amb.1_5'UTR	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	235						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						TTCTGGAGAACTGATTAGGGA	0.353													T	32833790	T	T	32833790	3	4	62	1	0	0	0	0	1	0	0	0	1492	565	20	3	855	3	BPIL2	22	32833790	Missense_Mutation	SNP	C	TCGA-06-0747-01A-01W-0348-08	13033918	32833790	18470776	90	4153											
SYN3	8224	broad.mit.edu	37	chr22	33402361	33402361	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgtatgggcatcatcgatcAccaacaggatcctgggtctt	10	11	3	0			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chr22:33402361A>G	uc003amx.2	-	1	446	c.287T>C	c.(286-288)GTG>GCG	p.V96A	SYN3_uc003amy.2_Missense_Mutation_p.V96A|SYN3_uc003amz.2_Missense_Mutation_p.V96A	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	96	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						ATCATCGATCACCAACAGGAT	0.547													G	33402361	G	G	33402361	3	3	62	1	0	0	0	0	1	0	0	0	15439	159	6	4	1507	4	SYN3	22	33402361	Missense_Mutation	SNP	A	TCGA-06-0747-01A-01W-0348-08	568571	33402361	17902205	91	4154											
PCDH11Y	83259	broad.mit.edu	37	chrY	5605524	5605524	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gtgacacagaccattgttctCtgccacagccctccagtgac	8	15	1	3			TCGA-06-0747-01A-01W-0348-08	TCGA-06-0747-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	7773738f-f5dd-48ae-870c-aa89aea77450	edc2c7dd-acde-4bbc-ae3a-4f3ccdcf712d	g.chrY:5605524C>A	uc004fqo.2	+	5	4298	c.3564C>A	c.(3562-3564)CTC>CTA	p.L1188L		NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	1188	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						CCATTGTTCTCTGCCACAGCC	0.582													A	5605524	A	A	5605524	2	1	62	1	0	0	0	0	0	0	0	1	11509	900	32	5		5	PCDH11Y	24	5605524	Silent	SNP	C	TCGA-06-0747-01A-01W-0348-08		5605524	53768042	92	4155											
ARHGEF10L	55160	broad.mit.edu	37	chr1	17990973	17990973	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggacctggagagccctccCgtgtgcctgactgtggggcc	16	13	0	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:17990973C>T	uc001ban.2	+	26	3051	c.2892C>T	c.(2890-2892)CCC>CCT	p.P964P	ARHGEF10L_uc009vpe.1_Silent_p.P925P|ARHGEF10L_uc001bao.2_Silent_p.P925P|ARHGEF10L_uc001bap.2_Silent_p.P920P|ARHGEF10L_uc001baq.2_Silent_p.P725P|ARHGEF10L_uc010ocs.1_Silent_p.P737P|ARHGEF10L_uc001bar.2_Silent_p.P667P|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	964					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		AGAGCCCTCCCGTGTGCCTGA	0.692													T	17990973	T	T	17990973	2	4	63	1	0	0	0	0	0	0	0	1	895	639	23	2		2	ARHGEF10L	1	17990973	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08		17990973	231259648	1	4156											
FLG	2312	broad.mit.edu	37	chr1	152276886	152276886	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagccatctcctgattgttcGtcattacgagtttgtctgct	9	10	3	1	rs144901359		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:152276886G>A	uc001ezu.1	-	3	10512	c.10476C>T	c.(10474-10476)GAC>GAT	p.D3492D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3492	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.D3492Y(1)		ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGATTGTTCGTCATTACGAG	0.567									Ichthyosis				A	152276886	A	A	152276886	2	1	63	1	0	0	0	0	0	0	0	1	5922	1136	40	1		1	FLG	1	152276886	Silent	SNP	G	TCGA-06-0749-01A-01W-0348-08	134285913	152276886	96973735	2	4157											
LCE2C	353140	broad.mit.edu	37	chr1	152648777	152648777	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccgactgctgtgagagtgaaCcttctgggggctctggctgc	15	11	2	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:152648777C>A	uc001fah.2	+	2	341	c.286C>A	c.(286-288)CCT>ACT	p.P96T		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	96	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGAGTGAACCTTCTGGGGG	0.662													A	152648777	A	A	152648777	3	1	63	1	0	0	0	0	1	0	0	0	8667	507	18	5	288	5	LCE2C	1	152648777	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	371891	152648777	96601844	3	4158											
NUP210L	91181	broad.mit.edu	37	chr1	154062058	154062058	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctggatgatttccaattcGgaatgtgagaacctttaagg	10	7	0	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:154062058G>A	uc001fdw.2	-	16	2272	c.2200C>T	c.(2200-2202)CGA>TGA	p.R734*	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Nonsense_Mutation_p.R734*	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	734						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TTTCCAATTCGGAATGTGAGA	0.423													A	154062058	A	A	154062058	4	1	63	1	0	0	0	0	0	1	0	0	10761	1124	39	2	3566	2	NUP210L	1	154062058	Nonsense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	1413281	154062058	95188563	4	4159											
ARHGAP30	257106	broad.mit.edu	37	chr1	161023102	161023102	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtgtgaggatgaactccaCgacgatggattgtacccgca	13	9	0	2	rs149577194		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:161023102C>T	uc001fxl.2	-	6	956	c.610G>A	c.(610-612)GTG>ATG	p.V204M	ARHGAP30_uc001fxk.2_Missense_Mutation_p.V204M|ARHGAP30_uc001fxm.2_Missense_Mutation_p.V50M|ARHGAP30_uc009wtx.2_Translation_Start_Site|ARHGAP30_uc001fxn.1_Missense_Mutation_p.V50M	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	204	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ATGAACTCCACGACGATGGAT	0.562													T	161023102	T	T	161023102	3	4	63	1	0	0	0	0	1	0	0	0	879	536	19	1	2723	1	ARHGAP30	1	161023102	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	6961044	161023102	88227519	5	4160											
NLRP3	114548	broad.mit.edu	37	chr1	247607348	247607348	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcactaatcagaatctcaCgcacctttacctgcgaggca	7	14	2	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr1:247607348C>T	uc001icr.2	+	9	2882	c.2744C>T	c.(2743-2745)ACG>ATG	p.T915M	NLRP3_uc001ics.2_Missense_Mutation_p.T858M|NLRP3_uc001icu.2_Missense_Mutation_p.T915M|NLRP3_uc001icw.2_Missense_Mutation_p.T858M|NLRP3_uc001icv.2_Missense_Mutation_p.T801M|NLRP3_uc010pyw.1_Missense_Mutation_p.T893M	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	915	LRR 7.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAGAATCTCACGCACCTTTAC	0.512													T	247607348	T	T	247607348	3	4	63	1	0	0	0	0	1	0	0	0	10478	536	19	1	2770	1	NLRP3	1	247607348	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	86584246	247607348	1643273	6	4161											
TAF1B	9014	broad.mit.edu	37	chr2	9994457	9994457	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttcccttccaccttagaaCgatgttttacataatttttg	4	9	0	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:9994457C>T	uc002qzz.2	+	5	406	c.306C>T	c.(304-306)AAC>AAT	p.N102N	TAF1B_uc010exc.2_Silent_p.N102N|TAF1B_uc002qzy.3_Silent_p.N102N|TAF1B_uc010yja.1_Translation_Start_Site|TAF1B_uc010exd.2_Translation_Start_Site	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	102					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CACCTTAGAACGATGTTTTAC	0.408													T	9994457	T	T	9994457	2	4	63	1	0	0	0	0	0	0	0	1	15517	535	19	1		1	TAF1B	2	9994457	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08		9994457	233204916	7	4162											
OTOF	9381	broad.mit.edu	37	chr2	26705441	26705441	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acaggggctcatagctgctcTtctgcactgaagtcttgccc	10	13	4	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:26705441T>C	uc002rhk.2	-	14	1539	c.1412A>G	c.(1411-1413)AAG>AGG	p.K471R		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	471	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATAGCTGCTCTTCTGCACTGA	0.448													C	26705441	C	C	26705441	3	2	63	1	0	0	0	0	1	0	0	0	11303	1609	56	4	5042	4	OTOF	2	26705441	Missense_Mutation	SNP	T	TCGA-06-0749-01A-01W-0348-08	16710984	26705441	216493932	8	4163											
BIRC6	57448	broad.mit.edu	37	chr2	32695356	32695356	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagccacagttacccatgcaTaggaggacagaaggtattaa	10	9	0	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:32695356T>A	uc010ezu.2	+	31	6602	c.6468T>A	c.(6466-6468)CAT>CAA	p.H2156Q		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2156					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TACCCATGCATAGGAGGACAG	0.318													A	32695356	A	A	32695356	3	1	63	1	0	0	0	0	1	0	0	0	1438	1403	49	5	6590	5	BIRC6	2	32695356	Missense_Mutation	SNP	T	TCGA-06-0749-01A-01W-0348-08	5989915	32695356	210504017	9	4164											
TET3	200424	broad.mit.edu	37	chr2	74275488	74275489	+	Frame_Shift_Del	DEL	AC	-	-													acccaccaagagtctgctggAcacacctgccaagagagccc							TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:74275488_74275489delAC	uc002skb.3	+	1	2039_2040	c.2039_2040delAC	c.(2038-2040)GACfs	p.D680fs	TET3_uc010fez.1_Frame_Shift_Del_p.D680fs	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	680							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGTCTGCTGGACACACCTGCCA	0.604													-	74275489	-	-	74275488	7	5	63	1	0	1	0	1	0	0	0	0	15768	275	10	0	2041	0	TET3	2	74275488	Frame_Shift_Del	DEL	AC	TCGA-06-0749-01A-01W-0348-08	41580132	74275488	168923885	10	4165											
POTEE	445582	broad.mit.edu	37	chr2	132021710	132021710	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacctcatgaagatcctcacCgagcgtggctataggttcac	9	12	3	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:132021710C>T	uc002tsn.2	+	15	2734	c.2682C>T	c.(2680-2682)ACC>ACT	p.T894T	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Silent_p.T494T|POTEE_uc002tsl.2_Silent_p.T476T|POTEE_uc010fmy.1_Silent_p.T358T	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	894	Actin-like.						ATP binding				0						AGATCCTCACCGAGCGTGGCT	0.587													T	132021710	T	T	132021710	2	4	63	1	0	0	0	0	0	0	0	1	12264	639	23	2		2	POTEE	2	132021710	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08	57746222	132021710	111177663	11	4166											
MYO1B	4430	broad.mit.edu	37	chr2	192275792	192275792	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttcttctcatatctcacagTgtaaaaaatacagggaccaa	5	9	3	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr2:192275792T>C	uc010fsg.2	+	27	3022	c.2767T>C	c.(2767-2769)TGT>CGT	p.C923R	MYO1B_uc002usq.2_Missense_Mutation_p.C865R|MYO1B_uc002usr.2_Missense_Mutation_p.C923R|MYO1B_uc002usu.2_Missense_Mutation_p.C168R|MYO1B_uc002usv.2_Missense_Mutation_p.C39R	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	923						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			TATCTCACAGTGTAAAAAATA	0.308													C	192275792	C	C	192275792	3	2	63	1	0	0	0	0	1	0	0	0	10069	1710	59	4	2869	4	MYO1B	2	192275792	Missense_Mutation	SNP	T	TCGA-06-0749-01A-01W-0348-08	60254082	192275792	50923581	12	4167											
FGD5	152273	broad.mit.edu	37	chr3	14862751	14862751	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccccctcctccctcatctttTatagagatggcaagaggaaa	7	13	2	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:14862751T>A	uc003bzc.2	+	1	2283	c.2173T>A	c.(2173-2175)TAT>AAT	p.Y725N	FGD5_uc011avk.1_Missense_Mutation_p.Y725N	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	725					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CCTCATCTTTTATAGAGATGG	0.577													A	14862751	A	A	14862751	3	1	63	1	0	0	0	0	1	0	0	0	5836	1754	61	5	2175	5	FGD5	3	14862751	Missense_Mutation	SNP	T	TCGA-06-0749-01A-01W-0348-08		14862751	183159679	13	4168											
DAG1	1605	broad.mit.edu	37	chr3	49568839	49568839	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accctgtggtgggttggcacAtcgccaataagaagccccct	11	13	0	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:49568839A>G	uc003cxc.3	+	3	1313	c.895A>G	c.(895-897)ATC>GTC	p.I299V		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	299	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GGGTTGGCACATCGCCAATAA	0.597													G	49568839	G	G	49568839	3	3	63	1	0	0	0	0	1	0	0	0	4225	217	8	4	901	4	DAG1	3	49568839	Missense_Mutation	SNP	A	TCGA-06-0749-01A-01W-0348-08	34706088	49568839	148453591	14	4169											
CASR	846	broad.mit.edu	37	chr3	121980530	121980530	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcacaattgcagctgatgaCgactatgggcggccggggat	16	9	0	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:121980530C>T	uc003eev.3	+	4	1020	c.648C>T	c.(646-648)GAC>GAT	p.D216D	CASR_uc003eew.3_Silent_p.D216D	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	216	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CAGCTGATGACGACTATGGGC	0.537													T	121980530	T	T	121980530	2	4	63	1	0	0	0	0	0	0	0	1	2682	535	19	1		1	CASR	3	121980530	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08	72411691	121980530	76041900	15	4170											
ADCY5	111	broad.mit.edu	37	chr3	123038564	123038564	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaaggtcaggaggaacttgCggacgtgctcagaccgaagc	15	9	2	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:123038564C>T	uc003egh.1	-	10	2213	c.2213G>A	c.(2212-2214)CGC>CAC	p.R738H	ADCY5_uc003egg.1_Missense_Mutation_p.R371H|ADCY5_uc003egi.1_Missense_Mutation_p.R297H	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	738	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GAGGAACTTGCGGACGTGCTC	0.587													T	123038564	T	T	123038564	3	4	63	1	0	0	0	0	1	0	0	0	297	768	27	1	1620	1	ADCY5	3	123038564	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	1058034	123038564	74983866	16	4171											
PIGZ	80235	broad.mit.edu	37	chr3	196675037	196675037	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaccagggtttgtggctccaCgagtgccccagaggtagagg	15	10	0	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr3:196675037C>T	uc003fxh.2	-	3	878	c.731G>A	c.(730-732)CGT>CAT	p.R244H		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	244					GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			ovary(3)	3	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		TGTGGCTCCACGAGTGCCCCA	0.637													T	196675037	T	T	196675037	3	4	63	1	0	0	0	0	1	0	0	0	11905	536	19	1	1012	1	PIGZ	3	196675037	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	73636473	196675037	1347393	17	4172											
ZNF718	255403	broad.mit.edu	37	chr4	155414	155414	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagagaaacccttctcatgCgaagaatgtggcaatgtctt	11	8	2	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr4:155414C>T	uc003fzt.3	+	8	1072	c.939C>T	c.(937-939)TGC>TGT	p.C313C	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_Missense_Mutation_p.A93V	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	313	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		CCTTCTCATGCGAAGAATGTG	0.373													T	155414	T	T	155414	2	4	63	1	0	0	0	0	0	0	0	1	18117	776	27	1		1	ZNF718	4	155414	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08		155414	190998862	18	4173											
RBM47	54502	broad.mit.edu	37	chr4	40440359	40440359	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcttgtcggccgcgctggcGtagacgatcacgtccagcac	12	14	2	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr4:40440359G>A	uc003gvc.2	-	4	1262	c.552C>T	c.(550-552)TAC>TAT	p.Y184Y	RBM47_uc003gvd.2_Silent_p.Y184Y|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Silent_p.Y146Y|RBM47_uc003gvg.1_Silent_p.Y184Y	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	184	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						CCGCGCTGGCGTAGACGATCA	0.647													A	40440359	A	A	40440359	2	1	63	1	0	0	0	0	0	0	0	1	13141	1140	40	1		1	RBM47	4	40440359	Silent	SNP	G	TCGA-06-0749-01A-01W-0348-08	40284945	40440359	150713917	19	4174											
ALB	213	broad.mit.edu	37	chr4	74283995	74283995	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccatgcagatatatgcacacTttctgagaaggagagacaaa	9	8	1	3			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr4:74283995T>A	uc003hgs.3	+	12	1692	c.1619T>A	c.(1618-1620)CTT>CAT	p.L540H	ALB_uc003hgw.3_Missense_Mutation_p.L348H|ALB_uc011cbe.1_Missense_Mutation_p.L219H|ALB_uc003hgt.3_Missense_Mutation_p.L540H|ALB_uc010iii.2_Missense_Mutation_p.L425H|ALB_uc003hgu.3_Missense_Mutation_p.L390H|ALB_uc003hgv.3_Missense_Mutation_p.L219H|ALB_uc011cbf.1_Missense_Mutation_p.L430H|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Missense_Mutation_p.L219H	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	540	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	ATATGCACACTTTCTGAGAAG	0.403													A	74283995	A	A	74283995	3	1	63	1	0	0	0	0	1	0	0	0	486	1609	56	5	1665	5	ALB	4	74283995	Missense_Mutation	SNP	T	TCGA-06-0749-01A-01W-0348-08	33843636	74283995	116870281	20	4175											
PPEF2	5470	broad.mit.edu	37	chr4	76793227	76793227	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgttagcttgatactgcaCaatatgtggggtcagggctg	13	7	1	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr4:76793227C>T	uc003hix.2	-	13	1957	c.1600G>A	c.(1600-1602)GTG>ATG	p.V534M	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.V534M	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	534	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGATACTGCACAATATGTGGG	0.428													T	76793227	T	T	76793227	3	4	63	1	0	0	0	0	1	0	0	0	12308	478	17	3	681	3	PPEF2	4	76793227	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	2509232	76793227	114361049	21	4176											
ADAMTS12	81792	broad.mit.edu	37	chr5	33596125	33596125	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgtagctttcaccatcccGcggcccttctttatgcaatg	7	13	2	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr5:33596125G>A	uc003jia.1	-	17	2731	c.2568C>T	c.(2566-2568)CGC>CGT	p.R856R	ADAMTS12_uc010iuq.1_Silent_p.R771R	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	856	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCACCATCCCGCGGCCCTTCT	0.512										HNSCC(64;0.19)			A	33596125	A	A	33596125	2	1	63	1	0	0	0	0	0	0	0	1	257	1074	38	1		1	ADAMTS12	5	33596125	Silent	SNP	G	TCGA-06-0749-01A-01W-0348-08		33596125	147319135	22	4177											
PCDHA10	56139	broad.mit.edu	37	chr5	140237259	140237259	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcgcgatgggggcgtgccGcctctgggcagcaacttgac	17	13	1	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr5:140237259G>A	uc003lhx.2	+	1	1626	c.1626G>A	c.(1624-1626)CCG>CCA	p.P542P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Silent_p.P542P	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	542	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGCGTGCCGCCTCTGGGCA	0.697													A	140237259	A	A	140237259	2	1	63	1	0	0	0	0	0	0	0	1	11520	1074	38	1		1	PCDHA10	5	140237259	Silent	SNP	G	TCGA-06-0749-01A-01W-0348-08	106641134	140237259	40678001	23	4178											
PCDHB5	26167	broad.mit.edu	37	chr5	140517047	140517052	+	In_Frame_Del	DEL	GGCCCA	-	-													ccgctgccggaggcggccccGgcccaggcccaggccgactc							TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr5:140517047_140517052delGGCCCA	uc003liq.2	+	1	2248_2253	c.2031_2036delGGCCCA	c.(2029-2037)CCGGCCCAG>CCG	p.AQ680del		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	680_681	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGCGGCCCCGGCCCAGGCCCAGGCC	0.694													-	140517052	-	-	140517047	7	5	63	1	0	1	0	1	0	0	0	0	11545	1103	39	0	2033	0	PCDHB5	5	140517047	In_Frame_Del	DEL	GGCCCA	TCGA-06-0749-01A-01W-0348-08	279788	140517047	40398213	24	4179											
RIPK1	8737	broad.mit.edu	37	chr6	3104537	3104537	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtggcagtaccttcaagcCggtcaaattcaggtaaatta	10	8	3	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr6:3104537C>T	uc010jni.2	+	8	1226	c.994C>T	c.(994-996)CGG>TGG	p.R332W	RIPK1_uc003muv.3_Missense_Mutation_p.R169W|RIPK1_uc003muw.3_Missense_Mutation_p.R267W|RIPK1_uc011dhs.1_Missense_Mutation_p.R286W|RIPK1_uc003mux.2_Missense_Mutation_p.R332W	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	332	Interaction with SQSTM1.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				ACCTTCAAGCCGGTCAAATTC	0.348													T	3104537	T	T	3104537	3	4	63	1	0	0	0	0	1	0	0	0	13380	643	23	2	1020	2	RIPK1	6	3104537	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08		3104537	168010530	25	4180											
OR2H1	26716	broad.mit.edu	37	chr6	29430405	29430405	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccttcacttaaccctctcGtatacaccctgaggaacaag	5	15	2	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr6:29430405G>A	uc003nmi.2	+	3	1302	c.859G>A	c.(859-861)GTA>ATA	p.V287I	OR2H1_uc003nmj.1_Missense_Mutation_p.V287I|OR2H1_uc010jri.1_Missense_Mutation_p.V209I	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TAACCCTCTCGTATACACCCT	0.493													A	29430405	A	A	29430405	3	1	63	1	0	0	0	0	1	0	0	0	11001	1145	40	1	861	1	OR2H1	6	29430405	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	26325868	29430405	141684662	26	4181											
GABBR1	2550	broad.mit.edu	37	chr6	29599228	29599228	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgttggccaggcacttgcgGaccttgggccccaccacctc	11	18	0	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr6:29599228G>A	uc003nmt.3	-	3	570	c.234C>T	c.(232-234)GTC>GTT	p.V78V	GABBR1_uc003nmu.3_Silent_p.V78V|GABBR1_uc011dlr.1_5'UTR|GABBR1_uc011dls.1_Silent_p.V78V	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	78	Sushi 1.|Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	GGCACTTGCGGACCTTGGGCC	0.602													A	29599228	A	A	29599228	2	1	63	1	0	0	0	0	0	0	0	1	6155	1161	41	3		3	GABBR1	6	29599228	Silent	SNP	G	TCGA-06-0749-01A-01W-0348-08	168823	29599228	141515839	27	4182											
TNRC18	84629	broad.mit.edu	37	chr7	5417608	5417608	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgagcagccgttcctcccGgtgtctggcccggtcgtcca	12	18	1	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:5417608G>A	uc003soi.3	-	6	2549	c.2200C>T	c.(2200-2202)CGG>TGG	p.R734W		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	734							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CGTTCCTCCCGGTGTCTGGCC	0.682													A	5417608	A	A	5417608	3	1	63	1	0	0	0	0	1	0	0	0	16336	1115	39	2	6806	2	TNRC18	7	5417608	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08		5417608	153721055	28	4183											
RAMP3	10268	broad.mit.edu	37	chr7	45216987	45216987	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgggaaggctttcgcagaCatgatgggcaaggtggacgt	17	6	0	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:45216987C>T	uc003tnb.2	+	2	199	c.138C>T	c.(136-138)GAC>GAT	p.D46D	RAMP3_uc003tnc.2_Silent_p.D14D	NM_005856	NP_005847	O60896	RAMP3_HUMAN	receptor activity modifying protein 3 precursor	46	Extracellular (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity				0					Pramlintide(DB01278)	CTTTCGCAGACATGATGGGCA	0.607													T	45216987	T	T	45216987	2	4	63	1	0	0	0	0	0	0	0	1	13023	477	17	3		3	RAMP3	7	45216987	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08	39799379	45216987	113921676	29	4184											
EGFR	1956	broad.mit.edu	37	chr7	55221821	55221821	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggcaaatacagctttggtGccacctgcgtgaagaagtgt	13	8	0	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:55221821G>A	uc003tqk.2	+	7	1111	c.865G>A	c.(865-867)GCC>ACC	p.A289T	EGFR_uc003tqh.2_Missense_Mutation_p.A289T|EGFR_uc003tqi.2_Missense_Mutation_p.A289T|EGFR_uc003tqj.2_Missense_Mutation_p.A289T|EGFR_uc010kzg.1_Missense_Mutation_p.A244T|EGFR_uc011kco.1_Missense_Mutation_p.A236T|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTTTGGTGCCACCTGCGT	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55221821	A	A	55221821	3	1	63	1	0	0	0	0	1	0	0	0	4967	1319	46	3	891	3	EGFR	7	55221821	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	10004834	55221821	103916842	30	4185											
EGFR	1956	broad.mit.edu	37	chr7	55249022	55249022	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagcgtggacaacccccacGtgtgccgcctgctgggcatc	12	17	0	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:55249022G>A	uc003tqk.2	+	20	2566	c.2320G>A	c.(2320-2322)GTG>ATG	p.V774M	EGFR_uc010kzg.1_Missense_Mutation_p.V729M|EGFR_uc011kco.1_Missense_Mutation_p.V721M|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	774	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.H773_V774insNPH(12)|p.V774_C775insHV(4)|p.H773_V774insPH(3)|p.H773_V774insH(3)|p.V774M(3)|p.H773_V774insGH(1)|p.H773_V774insG(1)|p.H773_V774>LM(1)|p.V774L(1)|p.H773_V774insGNPH(1)|p.V774del(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAACCCCCACGTGTGCCGCCT	0.632		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55249022	A	A	55249022	3	1	63	1	0	0	0	0	1	0	0	0	4967	1145	40	1	2662	1	EGFR	7	55249022	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	27201	55249022	103889641	31	4186											
PCLO	27445	broad.mit.edu	37	chr7	82582186	82582186	+	Frame_Shift_Del	DEL	A	-	-													ctctggaggaattgttatggAaatgctgctgagaccaacac							TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:82582186delA	uc003uhx.2	-	5	8372	c.8083delT	c.(8083-8085)TCCfs	p.S2695fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.S2695fs|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2626					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATTGTTATGGAAATGCTGCTG	0.413													-	82582186	-	-	82582186	7	5	63	1	0	1	0	1	0	0	0	0	11583	246	9	0	7446	0	PCLO	7	82582186	Frame_Shift_Del	DEL	A	TCGA-06-0749-01A-01W-0348-08	27333164	82582186	76556477	32	4187											
BAIAP2L1	55971	broad.mit.edu	37	chr7	97935824	97935824	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtacgacgacgggaaccaacCcctcctaccggcaaagaggg	12	14	0	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:97935824C>G	uc003upj.2	-	11	1431	c.1168G>C	c.(1168-1170)GGT>CGT	p.G390R	uc003upk.1_5'Flank	NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	390	SH3.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			GGGAACCAACCCCTCCTACCG	0.572													G	97935824	G	G	97935824	3	3	63	1	0	0	0	0	1	0	0	0	1302	623	22	5	383	5	BAIAP2L1	7	97935824	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	15353638	97935824	61202839	33	4188											
MCM7	4176	broad.mit.edu	37	chr7	99694927	99694927	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaagcccaactacttactgcGaggcgccagtcgatcaatgt	9	12	1	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:99694927G>A	uc003usw.1	-	10	1708	c.1198C>T	c.(1198-1200)CGC>TGC	p.R400C	MCM7_uc003usv.1_Missense_Mutation_p.R224C|MCM7_uc003usx.1_Missense_Mutation_p.R224C	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	400	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	TACTTACTGCGAGGCGCCAGT	0.473													A	99694927	A	A	99694927	3	1	63	1	0	0	0	0	1	0	0	0	9392	1058	37	2	985	2	MCM7	7	99694927	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	1759103	99694927	59443736	34	4189											
ASZ1	136991	broad.mit.edu	37	chr7	117020042	117020042	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctccaaattgtatctcttcTacctgtagttctttaagagc	5	10	4	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:117020042T>C	uc003vjb.2	-	10	1068	c.1005A>G	c.(1003-1005)GTA>GTG	p.V335V	ASZ1_uc011kno.1_Silent_p.V335V|ASZ1_uc011knp.1_Silent_p.V127V	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	335					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			GTATCTCTTCTACCTGTAGTT	0.308													C	117020042	C	C	117020042	2	2	63	1	0	0	0	0	0	0	0	1	1069	1509	53	4		4	ASZ1	7	117020042	Silent	SNP	T	TCGA-06-0749-01A-01W-0348-08	17325115	117020042	42118621	35	4190											
HIPK2	28996	broad.mit.edu	37	chr7	139416214	139416214	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccacttgcccaaacgtccctCggcccaagaactctaagacc	6	18	1	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:139416214C>T	uc003vvf.3	-	2	794	c.620G>A	c.(619-621)CGA>CAA	p.R207Q	HIPK2_uc003vvd.3_Missense_Mutation_p.R207Q	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	207	ATP (Probable).|Protein kinase.|Transcriptional corepression (By similarity).|Interaction with DAXX.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					AAACGTCCCTCGGCCCAAGAA	0.552													T	139416214	T	T	139416214	3	4	63	1	0	0	0	0	1	0	0	0	7117	884	31	2	3032	2	HIPK2	7	139416214	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	22396172	139416214	19722449	36	4191											
CLCN1	1180	broad.mit.edu	37	chr7	143048733	143048733	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagtctggggtgcagctccGccctccccttgccagcttcc	10	18	1	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr7:143048733G>A	uc003wcr.1	+	23	2729	c.2642G>A	c.(2641-2643)CGC>CAC	p.R881H	CLCN1_uc011ktc.1_Missense_Mutation_p.R493H	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	881	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					GTGCAGCTCCGCCCTCCCCTT	0.483													A	143048733	A	A	143048733	3	1	63	1	0	0	0	0	1	0	0	0	3462	1087	38	1	2732	1	CLCN1	7	143048733	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	3632519	143048733	16089930	37	4192											
KCNB2	9312	broad.mit.edu	37	chr8	73848914	73848914	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaggagggaggctcttgagCgggccaaaaggaacggaagc	17	7	1	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr8:73848914C>T	uc003xzb.2	+	3	1912	c.1324C>T	c.(1324-1326)CGG>TGG	p.R442W		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	442	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GGCTCTTGAGCGGGCCAAAAG	0.443													T	73848914	T	T	73848914	3	4	63	1	0	0	0	0	1	0	0	0	8013	759	27	1	1330	1	KCNB2	8	73848914	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08		73848914	72515108	38	4193											
KIFC2	90990	broad.mit.edu	37	chr8	145693119	145693119	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaggagctgaagcagcagcTggaacagcaggaggaggagt	19	6	0	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr8:145693119T>C	uc003zcz.2	+	6	703	c.638T>C	c.(637-639)CTG>CCG	p.L213P	CYHR1_uc003zcv.2_5'Flank|CYHR1_uc003zcw.2_5'Flank|CYHR1_uc003zcx.2_5'Flank|CYHR1_uc003zcy.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	213	Potential.|Gln-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AAGCAGCAGCTGGAACAGCAG	0.642											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	145693119	C	C	145693119	3	2	63	1	0	0	0	0	1	0	0	0	8313	1580	55	4	660	4	KIFC2	8	145693119	Missense_Mutation	SNP	T	TCGA-06-0749-01A-01W-0348-08	71844205	145693119	670903	39	4194											
BNC2	54796	broad.mit.edu	37	chr9	16419304	16419304	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccccactgtcactcgcccCgtcaatgtcatcgagaagaa	7	16	3	2	rs143124811	byFrequency	TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr9:16419304C>T	uc003zml.2	-	7	3123	c.2983G>A	c.(2983-2985)GGG>AGG	p.G995R	BNC2_uc011lmw.1_Missense_Mutation_p.G900R|BNC2_uc003zmm.2_3'UTR|BNC2_uc011lmv.1_3'UTR|BNC2_uc003zmj.2_3'UTR|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.G782R	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	995					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		TCACTCGCCCCGTCAATGTCA	0.592													T	16419304	T	T	16419304	3	4	63	1	0	0	0	0	1	0	0	0	1475	652	23	2	320	2	BNC2	9	16419304	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08		16419304	124794127	40	4195											
TAF1L	138474	broad.mit.edu	37	chr9	32631824	32631824	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcctggttccgcttaagccGcctcagttgctcttgaatcc	8	14	2	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr9:32631824G>A	uc003zrg.1	-	1	3844	c.3754C>T	c.(3754-3756)CGG>TGG	p.R1252W	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1252					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CGCTTAAGCCGCCTCAGTTGC	0.448													A	32631824	A	A	32631824	3	1	63	1	0	0	0	0	1	0	0	0	15520	1086	38	1	1730	1	TAF1L	9	32631824	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	16212520	32631824	108581607	41	4196											
PTEN	5728	broad.mit.edu	37	chr10	89720738	89720738	+	Frame_Shift_Del	DEL	G	-	-													tagaaaatggaagtctatgtGatcaagaaatcgatagcatt							TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr10:89720738delG	uc001kfb.2	+	9	1920	c.889delG	c.(889-891)GATfs	p.D297fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	297	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.G165_K342del(1)|p.W274_F341del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AAGTCTATGTGATCAAGAAAT	0.318		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89720738	-	-	89720738	7	5	63	1	0	1	0	1	0	0	0	0	12738	1290	45	0	919	0	PTEN	10	89720738	Frame_Shift_Del	DEL	G	TCGA-06-0749-01A-01W-0348-08		89720738	45814009	42	4197											
OR8K3	219473	broad.mit.edu	37	chr11	56086620	56086620	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttccatattttacaccctgGttatccccatgttgaatccc	4	14	0	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr11:56086620G>T	uc010rjf.1	+	1	838	c.838G>T	c.(838-840)GTT>TTT	p.V280F		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TTACACCCTGGTTATCCCCAT	0.378													T	56086620	T	T	56086620	3	4	63	1	0	0	0	0	1	0	0	0	11244	1261	44	5	840	5	OR8K3	11	56086620	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08		56086620	78919896	43	4198											
OR10W1	81341	broad.mit.edu	37	chr11	58034677	58034677	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cggccagcagccgagtggatCttgagcagagcagccactat	13	12	1	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr11:58034677C>A	uc001nmq.1	-	1	1056	c.654G>T	c.(652-654)AAG>AAT	p.K218N		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	218	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				CCGAGTGGATCTTGAGCAGAG	0.572													A	58034677	A	A	58034677	3	1	63	1	0	0	0	0	1	0	0	0	10921	912	32	5	267	5	OR10W1	11	58034677	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	1948057	58034677	76971839	44	4199											
OR4D5	219875	broad.mit.edu	37	chr11	123811000	123811000	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agcactgctagtcatgctccGaagccactcacgggagggcc	12	14	2	0	rs142766960		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr11:123811000G>A	uc001pzk.1	+	1	677	c.677G>A	c.(676-678)CGA>CAA	p.R226Q		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GTCATGCTCCGAAGCCACTCA	0.507													A	123811000	A	A	123811000	3	1	63	1	0	0	0	0	1	0	0	0	11057	1058	37	2	679	2	OR4D5	11	123811000	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	65776323	123811000	11195516	45	4200											
LRIG3	121227	broad.mit.edu	37	chr12	59272793	59272793	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tccttctgccaggctatctgGggggctgggtgccccacagc	14	14	2	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:59272793G>T	uc001sqr.2	-	14	2142	c.1896C>A	c.(1894-1896)CCC>CCA	p.P632P	LRIG3_uc009zqh.2_Silent_p.P572P|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	632	Ig-like C2-type 2.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			AGGCTATCTGGGGGGCTGGGT	0.597													T	59272793	T	T	59272793	2	4	63	1	0	0	0	0	0	0	0	1	8946	1219	43	5		5	LRIG3	12	59272793	Silent	SNP	G	TCGA-06-0749-01A-01W-0348-08		59272793	74579102	46	4201											
NAV3	89795	broad.mit.edu	37	chr12	78582438	78582438	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagccttggtctgagctctgActgcattgctagctactgta	10	10	2	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:78582438A>C	uc001syp.2	+	33	6109	c.5936A>C	c.(5935-5937)GAC>GCC	p.D1979A	NAV3_uc001syo.2_Missense_Mutation_p.D1957A|NAV3_uc010sub.1_Missense_Mutation_p.D1436A|NAV3_uc009zsf.2_Missense_Mutation_p.D788A	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1979						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTGAGCTCTGACTGCATTGCT	0.388										HNSCC(70;0.22)			C	78582438	C	C	78582438	3	2	63	1	0	0	0	0	1	0	0	0	10185	275	10	5	5996	5	NAV3	12	78582438	Missense_Mutation	SNP	A	TCGA-06-0749-01A-01W-0348-08	19309645	78582438	55269457	47	4202											
PLEKHG7	440107	broad.mit.edu	37	chr12	93148040	93148040	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaggtggaaaagtccatcCgtaagtccctgagataagtg	11	7	0	1	rs115752910	by1000genomes	TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:93148040C>T	uc001tcj.2	+	6	720	c.490C>T	c.(490-492)CGG>TGG	p.R164W		NM_001004330	NP_001004330	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G	164	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1						AAAGTCCATCCGTAAGTCCCT	0.438													T	93148040	T	T	93148040	3	4	63	1	0	0	0	0	1	0	0	0	12075	666	23	2	508	2	PLEKHG7	12	93148040	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	14565602	93148040	40703855	48	4203											
STAB2	55576	broad.mit.edu	37	chr12	104014256	104014256	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gattccctagagtgcccaggTggagcggggtcaccctgcaa	14	12	1	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:104014256T>G	uc001tjw.2	+	4	528	c.342T>G	c.(340-342)GGT>GGG	p.G114G		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	114	Extracellular (Potential).|EGF-like 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AGTGCCCAGGTGGAGCGGGGT	0.493													G	104014256	G	G	104014256	2	3	63	1	0	0	0	0	0	0	0	1	15237	1683	59	5		5	STAB2	12	104014256	Silent	SNP	T	TCGA-06-0749-01A-01W-0348-08	10866216	104014256	29837639	49	4204											
GPR133	283383	broad.mit.edu	37	chr12	131622720	131622720	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacaaaaccaaggtctggtcGctcacgagcagctctgcccg	10	15	3	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr12:131622720G>A	uc001uit.3	+	24	3034	c.2475G>A	c.(2473-2475)TCG>TCA	p.S825S	GPR133_uc010tbm.1_Silent_p.S857S|GPR133_uc009zyo.2_Silent_p.S107S|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	825	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		AGGTCTGGTCGCTCACGAGCA	0.597													A	131622720	A	A	131622720	2	1	63	1	0	0	0	0	0	0	0	1	6643	1074	38	1		1	GPR133	12	131622720	Silent	SNP	G	TCGA-06-0749-01A-01W-0348-08	27608464	131622720	2229175	50	4205											
ERCC5	2073	broad.mit.edu	37	chr13	103474461	103474462	+	Frame_Shift_Ins	INS	-	A	A													ccatgtaaaaggatgctcttINSatgttctatataagcctcat							TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr13:103474461_103474462insA	uc001vpu.1	+	5	975_976	c.853_854insA	c.(853-855)TATfs	p.Y285fs	BIVM_uc001vps.2_Frame_Shift_Ins_p.Y285fs|BIVM_uc010agc.2_Frame_Shift_Ins_p.Y56fs|BIVM_uc001vpv.2_Frame_Shift_Ins_p.Y56fs	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	Error:Variant_position_missing_in_P28715_after_alignment					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AGGATGCTCTTATGTTCTATAT	0.297			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				A	103474462	A	A	103474461	7	5	63	1	0	1	1	0	0	0	0	0	5216	1754	61	0		0	ERCC5	13	103474461	Frame_Shift_Ins	INS	-	TCGA-06-0749-01A-01W-0348-08		103474461	11695417	51	4206											
FUT8	2530	broad.mit.edu	37	chr14	66028372	66028372	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atataggtggtcacttggtaCgagataatgaccatcctgat	10	7	1	3			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr14:66028372C>T	uc001xin.2	+	3	1288	c.91C>T	c.(91-93)CGA>TGA	p.R31*	FUT8_uc001xio.2_Nonsense_Mutation_p.R31*|FUT8_uc010tsp.1_Intron|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Nonsense_Mutation_p.R31*|FUT8_uc001xiq.2_Intron	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	31	Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TCACTTGGTACGAGATAATGA	0.458													T	66028372	T	T	66028372	4	4	63	1	0	0	0	0	0	1	0	0	6110	528	19	1	93	1	FUT8	14	66028372	Nonsense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08		66028372	41321168	52	4207											
AK7	122481	broad.mit.edu	37	chr14	96917806	96917806	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acttaagaatggaagcgctcTttgtgaaggagaattttaat	10	4	1	3			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr14:96917806T>C	uc001yfn.2	+	10	1041	c.997T>C	c.(997-999)TTT>CTT	p.F333L		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	333	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GGAAGCGCTCTTTGTGAAGGA	0.368													C	96917806	C	C	96917806	3	2	63	1	0	0	0	0	1	0	0	0	444	1609	56	4	1035	4	AK7	14	96917806	Missense_Mutation	SNP	T	TCGA-06-0749-01A-01W-0348-08	30889434	96917806	10431734	53	4208											
CREBBP	1387	broad.mit.edu	37	chr16	3842056	3842056	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtcgtgtgcagttcttcCaatgagagatgatttgtcgt	11	7	1	3			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr16:3842056C>T	uc002cvv.2	-	5	1460	c.1256G>A	c.(1255-1257)TGG>TAG	p.W419*	CREBBP_uc002cvw.2_Intron	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	419	TAZ-type 1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCAGTTCTTCCAATGAGAGAT	0.428			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				T	3842056	T	T	3842056	4	4	63	1	0	0	0	0	0	1	0	0	3861	595	21	3	6180	3	CREBBP	16	3842056	Nonsense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08		3842056	86512697	54	4209											
CIITA	4261	broad.mit.edu	37	chr16	11000852	11000852	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgctcatcctagacggcttCgaggagctggaagcgcaaga	13	11	1	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr16:11000852C>T	uc002dai.3	+	11	1636	c.1503C>T	c.(1501-1503)TTC>TTT	p.F501F	CIITA_uc002daj.3_Silent_p.F502F|CIITA_uc002dak.3_Intron|CIITA_uc002dag.2_Silent_p.F501F|CIITA_uc002dah.2_Silent_p.F453F|CIITA_uc010bup.1_Intron	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	501	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						TAGACGGCTTCGAGGAGCTGG	0.647			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								T	11000852	T	T	11000852	2	4	63	1	0	0	0	0	0	0	0	1	3428	883	31	2		2	CIITA	16	11000852	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08	7158796	11000852	79353901	55	4210											
PRKCB	5579	broad.mit.edu	37	chr16	24166139	24166139	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggccctgcctgggaagccGcccttcctgacccagctcca	10	18	0	1	rs141827066		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr16:24166139G>A	uc002dmd.2	+	10	1397	c.1200G>A	c.(1198-1200)CCG>CCA	p.P400P	PRKCB_uc002dme.2_Silent_p.P400P	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	400	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding	p.P400P(1)		ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CTGGGAAGCCGCCCTTCCTGA	0.567													A	24166139	A	A	24166139	2	1	63	1	0	0	0	0	0	0	0	1	12508	1074	38	1		1	PRKCB	16	24166139	Silent	SNP	G	TCGA-06-0749-01A-01W-0348-08	13165287	24166139	66188614	56	4211											
LCMT1	51451	broad.mit.edu	37	chr16	25143735	25143735	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccccctaggatattttgctcGagtccatggtgtcagtcagc	10	12	2	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr16:25143735G>A	uc002dnx.1	+	3	376	c.218G>A	c.(217-219)CGA>CAA	p.R73Q	LCMT1_uc002dny.1_Missense_Mutation_p.R73Q|LCMT1_uc002dnz.1_5'UTR|LCMT1_uc002doa.1_5'UTR	NM_016309	NP_057393	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1 isoform a	73		S-adenosyl-L-methionine.					protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity				0				GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	TATTTTGCTCGAGTCCATGGT	0.488													A	25143735	A	A	25143735	3	1	63	1	0	0	0	0	1	0	0	0	8678	1058	37	2	228	2	LCMT1	16	25143735	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	977596	25143735	65211018	57	4212											
MYH2	4620	broad.mit.edu	37	chr17	10427836	10427836	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccaggagctcctgttctgCgatttttctgctcctctctg	8	13	3	0	rs147813930		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:10427836C>T	uc010coi.2	-	35	5250	c.5122G>A	c.(5122-5124)GCA>ACA	p.A1708T	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.A1708T|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1708	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCCTGTTCTGCGATTTTTCTG	0.547													T	10427836	T	T	10427836	3	4	63	1	0	0	0	0	1	0	0	0	10035	768	27	1	727	1	MYH2	17	10427836	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08		10427836	70767374	58	4213											
KRT16	3868	broad.mit.edu	37	chr17	39767641	39767641	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccagctcctccttcaggcCttcgatctgcatctccaggt	9	16	3	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:39767641C>T	uc002hxg.3	-	3	866	c.727G>A	c.(727-729)GGC>AGC	p.G243S	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	243	Coil 1B.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				TCCTTCAGGCCTTCGATCTGC	0.642													T	39767641	T	T	39767641	3	4	63	1	0	0	0	0	1	0	0	0	8453	681	24	3	718	3	KRT16	17	39767641	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	29339805	39767641	41427569	59	4214											
KIF2B	84643	broad.mit.edu	37	chr17	51900949	51900949	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aataccagaaaccccaactaCgaaatcatgcacatgatcga	5	12	1	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:51900949C>T	uc002iua.2	+	1	711	c.555C>T	c.(553-555)TAC>TAT	p.Y185Y	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	185					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						ACCCCAACTACGAAATCATGC	0.562													T	51900949	T	T	51900949	2	4	63	1	0	0	0	0	0	0	0	1	8298	547	19	1		1	KIF2B	17	51900949	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08	12133308	51900949	29294261	60	4215											
ANKFN1	162282	broad.mit.edu	37	chr17	54452045	54452045	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttccaagagcctcttagcGtcaatgcagctgtagtaacc	9	12	2	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:54452045G>A	uc002iun.1	+	7	924	c.889G>A	c.(889-891)GTC>ATC	p.V297I		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	297	Fibronectin type-III.									large_intestine(1)|ovary(1)	2						GCCTCTTAGCGTCAATGCAGC	0.458													A	54452045	A	A	54452045	3	1	63	1	0	0	0	0	1	0	0	0	625	1145	40	1	915	1	ANKFN1	17	54452045	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	2551096	54452045	26743165	61	4216											
CCDC46	201134	broad.mit.edu	37	chr17	63848135	63848135	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaacttgtgaacctgggcCtccatgtcggcaataacctt	8	13	1	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr17:63848135C>T	uc002jfl.2	-	21	2400	c.2181G>A	c.(2179-2181)GAG>GAA	p.E727E	CCDC46_uc010deo.2_Silent_p.E469E|CCDC46_uc002jfm.2_Silent_p.E727E|CCDC46_uc010dep.2_Silent_p.E685E	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	727	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			GAACCTGGGCCTCCATGTCGG	0.284													T	63848135	T	T	63848135	2	4	63	1	0	0	0	0	0	0	0	1	2817	680	24	3		3	CCDC46	17	63848135	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08	9396090	63848135	17347075	62	4217											
MC5R	4161	broad.mit.edu	37	chr18	13826256	13826256	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctcaggggccatcatcgcCggcatctgggctttctgcac	12	15	4	0	rs45575841	byFrequency	TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr18:13826256C>T	uc010xaf.1	+	1	492	c.492C>T	c.(490-492)GCC>GCT	p.A164A		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	164	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						CCATCATCGCCGGCATCTGGG	0.572													T	13826256	T	T	13826256	2	4	63	1	0	0	0	0	0	0	0	1	9367	639	23	2		2	MC5R	18	13826256	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08		13826256	64250992	63	4218											
LASS4	79603	broad.mit.edu	37	chr19	8320541	8320541	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggcctcacgctgcagcagacCcagcgatggttccggagacg	14	14	1	2			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr19:8320541C>G	uc002mjg.2	+	5	662	c.342C>G	c.(340-342)ACC>ACG	p.T114T	LASS4_uc002mjh.2_Silent_p.T63T|LASS4_uc002mji.2_5'UTR|LASS4_uc010dvz.2_Silent_p.T114T	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4	114	Homeobox.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						TGCAGCAGACCCAGCGATGGT	0.652													G	8320541	G	G	8320541	2	3	63	1	0	0	0	0	0	0	0	1	8641	610	22	5		5	LASS4	19	8320541	Silent	SNP	C	TCGA-06-0749-01A-01W-0348-08		8320541	50808442	64	4219											
CYP4F2	8529	broad.mit.edu	37	chr19	15990424	15990424	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccccgcacctcagggtccGgccacacagctgggttgtga	14	15	1	1			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr19:15990424G>A	uc002nbs.1	-	11	1354	c.1304C>T	c.(1303-1305)CCG>CTG	p.P435L	CYP4F2_uc010xot.1_Missense_Mutation_p.P286L	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	435					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CTCAGGGTCCGGCCACACAGC	0.567													A	15990424	A	A	15990424	3	1	63	1	0	0	0	0	1	0	0	0	4188	1116	39	2	270	2	CYP4F2	19	15990424	Missense_Mutation	SNP	G	TCGA-06-0749-01A-01W-0348-08	7669883	15990424	43138559	65	4220											
MATN4	8785	broad.mit.edu	37	chr20	43929967	43929967	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggggtgttgctcacccctgcAgctcctctggtcctgctgga	13	14	2	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr20:43929967A>G	uc002xnn.2	-	4	947	c.760T>C	c.(760-762)TGC>CGC	p.C254R	MATN4_uc002xno.2_Intron|MATN4_uc002xnp.2_Intron|MATN4_uc010zwr.1_Missense_Mutation_p.C202R|MATN4_uc002xnr.1_Missense_Mutation_p.C254R	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	295						extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				TCACCCCTGCAGCTCCTCTGG	0.587											OREG0025977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	43929967	G	G	43929967	3	3	63	1	0	0	0	0	1	0	0	0	9336	188	7	4	1013	4	MATN4	20	43929967	Missense_Mutation	SNP	A	TCGA-06-0749-01A-01W-0348-08		43929967	19095553	66	4221											
OPRL1	4987	broad.mit.edu	37	chr20	62724089	62724089	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggcatggagcccctcttcCccgcgccgttctgggaggtt	14	14	2	0	rs148535906		TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr20:62724089C>T	uc002yic.2	+	3	418	c.16C>T	c.(16-18)CCC>TCC	p.P6S	OPRL1_uc002yid.2_Missense_Mutation_p.P6S|OPRL1_uc002yif.3_Missense_Mutation_p.P6S	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	6	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GCCCCTCTTCCCCGCGCCGTT	0.632													T	62724089	T	T	62724089	3	4	63	1	0	0	0	0	1	0	0	0	10886	623	22	3	18	3	OPRL1	20	62724089	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	18794122	62724089	301431	67	4222											
KCNJ15	3772	broad.mit.edu	37	chr21	39671533	39671533	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggactctctcactggggCgtttctcttttccctggaat	10	11	3	0			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr21:39671533C>T	uc002ywv.2	+	4	652	c.350C>T	c.(349-351)GCG>GTG	p.A117V	KCNJ15_uc002yww.2_Missense_Mutation_p.A117V|KCNJ15_uc002ywx.2_Missense_Mutation_p.A117V	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	117					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						CTCACTGGGGCGTTTCTCTTT	0.493													T	39671533	T	T	39671533	3	4	63	1	0	0	0	0	1	0	0	0	8049	768	27	1	352	1	KCNJ15	21	39671533	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08		39671533	8458362	68	4223											
UMODL1	89766	broad.mit.edu	37	chr21	43522316	43522316	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acaataaagattgtaaaccaCaacctgacggagaagttact	7	8	0	3			TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chr21:43522316C>A	uc002zaf.1	+	8	1227	c.1227C>A	c.(1225-1227)CAC>CAA	p.H409Q	UMODL1_uc002zad.1_Missense_Mutation_p.H337Q|UMODL1_uc002zae.1_Missense_Mutation_p.H337Q|UMODL1_uc002zag.1_Missense_Mutation_p.H409Q|UMODL1_uc010gow.1_Missense_Mutation_p.H201Q|UMODL1_uc002zai.1_Missense_Mutation_p.H60Q|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Missense_Mutation_p.H60Q|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.H154Q|C21orf128_uc002zak.2_3'UTR	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	409	Extracellular (Potential).|SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TTGTAAACCACAACCTGACGG	0.428													A	43522316	A	A	43522316	3	1	63	1	0	0	0	0	1	0	0	0	16977	477	17	5	1257	5	UMODL1	21	43522316	Missense_Mutation	SNP	C	TCGA-06-0749-01A-01W-0348-08	3850783	43522316	4607579	69	4224											
STAG2	10735	broad.mit.edu	37	chrX	123205046	123205047	+	Frame_Shift_Del	DEL	TA	-	-													atgatcttcagccatcagatTatgtcaggagggcgtgacat							TCGA-06-0749-01A-01W-0348-08	TCGA-06-0749-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	1121aced-04ae-4ba2-a467-c5b8445a0a76	87c88d13-a280-4497-9925-ed79bfa82db5	g.chrX:123205046_123205047delTA	uc004etz.3	+	24	2745_2746	c.2406_2407delTA	c.(2404-2409)ATTATGfs	p.I802fs	STAG2_uc004eua.2_Frame_Shift_Del_p.I802fs|STAG2_uc004eub.2_Frame_Shift_Del_p.I802fs|STAG2_uc004euc.2_Frame_Shift_Del_p.I802fs|STAG2_uc004eud.2_Frame_Shift_Del_p.I802fs|STAG2_uc004eue.2_Frame_Shift_Del_p.I802fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	802_803					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GCCATCAGATTATGTCAGGAGG	0.376													-	123205047	-	-	123205046	7	5	63	1	0	1	0	1	0	0	0	0	15242	1742	61	0	2496	0	STAG2	23	123205046	Frame_Shift_Del	DEL	TA	TCGA-06-0749-01A-01W-0348-08		123205046	32065514	70	4225											
SCNN1D	6339	broad.mit.edu	37	chr1	1222331	1222331	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctgagccactcgggcagCcgggtcagagtggggttcag	18	10	2	2			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr1:1222331C>T	uc001adu.1	+	7	1227	c.603C>T	c.(601-603)AGC>AGT	p.S201S	SCNN1D_uc001adt.1_Silent_p.S365S|SCNN1D_uc001adw.2_Silent_p.S267S|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Silent_p.S201S	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		ACTCGGGCAGCCGGGTCAGAG	0.697													T	1222331	T	T	1222331	2	4	64	1	0	0	0	0	0	0	0	1	13929	738	26	3		3	SCNN1D	1	1222331	Silent	SNP	C	TCGA-06-0750-01A-01W-0348-08		1222331	248028290	1	4226											
SYDE2	84144	broad.mit.edu	37	chr1	85656020	85656020	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gagtcggcctcaccaaaactCaaggcacttgatataccaag	8	12	2	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr1:85656020C>A	uc009wcm.2	-	2	1210	c.1161G>T	c.(1159-1161)TTG>TTT	p.L387F	SYDE2_uc001dku.3_Missense_Mutation_p.L387F	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	387					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		CACCAAAACTCAAGGCACTTG	0.448													A	85656020	A	A	85656020	3	1	64	1	0	0	0	0	1	0	0	0	15433	825	29	5	2447	5	SYDE2	1	85656020	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08	84433689	85656020	163594601	2	4227											
FLG	2312	broad.mit.edu	37	chr1	152281389	152281389	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgcctgttcatgggatgaCgcagcctgtccacgagagga	13	11	1	2	rs138652718	byFrequency	TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr1:152281389C>T	uc001ezu.1	-	3	6009	c.5973G>A	c.(5971-5973)GCG>GCA	p.A1991A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1991	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGGATGACGCAGCCTGTC	0.572									Ichthyosis				T	152281389	T	T	152281389	2	4	64	1	0	0	0	0	0	0	0	1	5922	523	19	1		1	FLG	1	152281389	Silent	SNP	C	TCGA-06-0750-01A-01W-0348-08	66625369	152281389	96969232	3	4228											
KLHL20	27252	broad.mit.edu	37	chr1	173744944	173744944	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caaccccagaaccaaccagtGgtctccagtggtggccatga	10	14	1	2			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr1:173744944G>T	uc001gjc.2	+	10	1780	c.1601G>T	c.(1600-1602)TGG>TTG	p.W534L	KLHL20_uc010pmr.1_Missense_Mutation_p.W345L|KLHL20_uc009wwf.2_Missense_Mutation_p.W516L	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	534	Kelch 5.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						ACCAACCAGTGGTCTCCAGTG	0.378													T	173744944	T	T	173744944	3	4	64	1	0	0	0	0	1	0	0	0	8375	1357	47	5	1635	5	KLHL20	1	173744944	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	21463555	173744944	75505677	4	4229											
GPR17	2840	broad.mit.edu	37	chr2	128408380	128408380	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggccacggcagagcaatgtgGccaggagacgccactggaga	16	11	0	3			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr2:128408380G>T	uc010yzn.1	+	4	766	c.155G>T	c.(154-156)GGC>GTC	p.G52V	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Missense_Mutation_p.G52V|GPR17_uc010yzo.1_Missense_Mutation_p.G24V|GPR17_uc002tpd.2_Missense_Mutation_p.G24V	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	52	Extracellular (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		gagcaatgtggccaggagacg	0.08											OREG0014966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	128408380	T	T	128408380	3	4	64	1	0	0	0	0	1	0	0	0	6667	1203	42	5	161	5	GPR17	2	128408380	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08		128408380	114790993	5	4230											
FAM123C	205147	broad.mit.edu	37	chr2	131521709	131521709	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccctgaagatcagctcaaaCgaacagcccccggccgcatg	10	16	2	2			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr2:131521709C>T	uc002trw.2	+	2	2254	c.2064C>T	c.(2062-2064)AAC>AAT	p.N688N	FAM123C_uc010fmv.2_Silent_p.N688N|FAM123C_uc010fms.1_Silent_p.N688N|FAM123C_uc010fmt.1_Silent_p.N688N|FAM123C_uc010fmu.1_Silent_p.N688N	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	688										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		TCAGCTCAAACGAACAGCCCC	0.652													T	131521709	T	T	131521709	2	4	64	1	0	0	0	0	0	0	0	1	5424	535	19	1		1	FAM123C	2	131521709	Silent	SNP	C	TCGA-06-0750-01A-01W-0348-08	3113329	131521709	111677664	6	4231											
TMEM144	55314	broad.mit.edu	37	chr4	159136389	159136389	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gctgccatatggttggttgcCttggttgtcaatctgatatt	11	7	2	1	rs149733307		TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr4:159136389C>G	uc003ipx.2	+	4	676	c.156C>G	c.(154-156)GCC>GCG	p.A52A	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	52	Helical; (Potential).					integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		GGTTGGTTGCCTTGGTTGTCA	0.383													G	159136389	G	G	159136389	2	3	64	1	0	0	0	0	0	0	0	1	16055	668	24	5		5	TMEM144	4	159136389	Silent	SNP	C	TCGA-06-0750-01A-01W-0348-08		159136389	32017887	7	4232											
PIK3R1	5295	broad.mit.edu	37	chr5	67591246	67591246	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttttcaaaactgtttttcAggtggttgactcaaaaaggt	8	6	4	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr5:67591246A>G	uc003jva.2	+	14	2306	c.1746_splice	c.e14-2	p.M582_splice	PIK3R1_uc003jvb.2_Splice_Site_p.M582_splice|PIK3R1_uc003jvc.2_Splice_Site_p.M282_splice|PIK3R1_uc003jvd.2_Splice_Site_p.M312_splice|PIK3R1_uc003jve.2_Splice_Site_p.M261_splice|PIK3R1_uc011crb.1_Splice_Site_p.M252_splice	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(2)|p.Y580fs*1(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	ACTGTTTTTCAGGTGGTTGAC	0.363			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			G	67591246	G	G	67591246	5	3	64	1	0	0	0	0	0	0	1	0	11918	202	7	4	1924	4	PIK3R1	5	67591246	Splice_Site	SNP	A	TCGA-06-0750-01A-01W-0348-08		67591246	113324014	8	4233											
FSTL4	23105	broad.mit.edu	37	chr5	132535036	132535036	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacagctccaggaacagcagGtccggctccgtgtgcagagc	14	13	0	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr5:132535036G>T	uc003kyn.1	-	16	2498	c.2280C>A	c.(2278-2280)GAC>GAA	p.D760E	FSTL4_uc003kym.1_Missense_Mutation_p.D409E	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	760						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAACAGCAGGTCCGGCTCCG	0.582													T	132535036	T	T	132535036	3	4	64	1	0	0	0	0	1	0	0	0	6079	1252	44	5	252	5	FSTL4	5	132535036	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	64943790	132535036	48380224	9	4234											
ARHGAP26	23092	broad.mit.edu	37	chr5	142281566	142281566	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgaactggccaaggatttcGgggacttcaagacacagtta	11	9	1	1	rs148543665		TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr5:142281566G>A	uc011dbj.1	+	7	699	c.664G>A	c.(664-666)GGG>AGG	p.G222R	ARHGAP26_uc003lmt.2_Missense_Mutation_p.G222R|ARHGAP26_uc003lmw.2_Missense_Mutation_p.G222R	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	222					actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAAGGATTTCGGGGACTTCAA	0.448													A	142281566	A	A	142281566	3	1	64	1	0	0	0	0	1	0	0	0	875	1116	39	2	690	2	ARHGAP26	5	142281566	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	9746530	142281566	38633694	10	4235											
SNX14	57231	broad.mit.edu	37	chr6	86253476	86253476	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	taaaattctatcattaaattCctctaacaaatgagggaatg	5	6	3	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr6:86253476C>A	uc003pkr.2	-	13	1304	c.1111G>T	c.(1111-1113)GAA>TAA	p.E371*	SNX14_uc003pkp.2_Nonsense_Mutation_p.E234*|SNX14_uc003pkq.2_5'UTR|SNX14_uc011dzg.1_Nonsense_Mutation_p.E319*|SNX14_uc003pks.2_Nonsense_Mutation_p.E327*|SNX14_uc003pkt.2_Nonsense_Mutation_p.E371*	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	371	RGS.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		TCATTAAATTCCTCTAACAAA	0.279													A	86253476	A	A	86253476	4	1	64	1	0	0	0	0	0	1	0	0	14885	864	30	5	1797	5	SNX14	6	86253476	Nonsense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08		86253476	84861591	11	4236											
EGFR	1956	broad.mit.edu	37	chr7	55221821	55221822	+	Missense_Mutation	DNP	GC	AA	AA													agggcaaatacagctttggtGccacctgcgtgaagaagtgt					rs149840192		TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr7:55221821_55221822GC>AA	uc003tqk.2	+	7	1111_1112	c.865_866GC>AA	c.(865-867)GCC>AAC	p.A289N	EGFR_uc003tqh.2_Missense_Mutation_p.A289N|EGFR_uc003tqi.2_Missense_Mutation_p.A289N|EGFR_uc003tqj.2_Missense_Mutation_p.A289N|EGFR_uc010kzg.1_Missense_Mutation_p.A244N|EGFR_uc011kco.1_Missense_Mutation_p.A236N|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTTTGGTGCCACCTGCGTG	0.589		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			AA	55221822	AA	AA	55221821	3	1	64	1	0	0	0	0	1	0	0	0	4967	1319	46	3	891	3	EGFR	7	55221821	Missense_Mutation	DNP	GC	TCGA-06-0750-01A-01W-0348-08		55221821	103916842	12	4237											
EGFR	1956	broad.mit.edu	37	chr7	55233037	55233037	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccactgcgtcaagacctgccCggcaggagtcatgggagaaa	13	12	2	2			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr7:55233037C>G	uc003tqk.2	+	15	2033	c.1787C>G	c.(1786-1788)CCG>CGG	p.P596R	EGFR_uc003tqi.2_Missense_Mutation_p.P596R|EGFR_uc003tqj.2_Missense_Mutation_p.P596R|EGFR_uc010kzg.1_Missense_Mutation_p.P551R|EGFR_uc011kco.1_Missense_Mutation_p.P543R|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	596	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.P596L(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAGACCTGCCCGGCAGGAGTC	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			G	55233037	G	G	55233037	3	3	64	1	0	0	0	0	1	0	0	0	4967	652	23	5	1856	5	EGFR	7	55233037	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08	11216	55233037	103905626	13	4238											
BPGM	669	broad.mit.edu	37	chr7	134346723	134346723	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttggatcaactgccacggtCggaaagcttaaaggatgttc	11	9	1	0			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr7:134346723C>T	uc003vrv.2	+	3	1005	c.464C>T	c.(463-465)TCG>TTG	p.S155L	BPGM_uc003vrw.2_Missense_Mutation_p.S155L|BPGM_uc003vrx.2_Missense_Mutation_p.S155L	NM_199186	NP_954655	P07738	PMGE_HUMAN	bisphosphoglycerate mutase	155					glycolysis|respiratory gaseous exchange		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						CTGCCACGGTCGGAAAGCTTA	0.473													T	134346723	T	T	134346723	3	4	64	1	0	0	0	0	1	0	0	0	1488	893	31	2	466	2	BPGM	7	134346723	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08	79113686	134346723	24791940	14	4239											
SLC34A3	142680	broad.mit.edu	37	chr9	140128961	140128961	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagagcagcagcgtcttcaCggcggccgtcgtgcccctca	13	16	3	1	rs138798032		TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr9:140128961C>T	uc004cmf.1	+	11	1373	c.1187C>T	c.(1186-1188)ACG>ATG	p.T396M	SLC34A3_uc011met.1_Missense_Mutation_p.T396M	NM_080877	NP_543153	Q8N130	NPT2C_HUMAN	solute carrier family 34 (sodium phosphate),	396	Extracellular (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		AGCGTCTTCACGGCGGCCGTC	0.721													T	140128961	T	T	140128961	3	4	64	1	0	0	0	0	1	0	0	0	14569	536	19	1	1225	1	SLC34A3	9	140128961	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08		140128961	1084470	15	4240											
PHLDA2	7262	broad.mit.edu	37	chr11	2950491	2950491	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcggggaacaggctcaggCggtcggaggtgagcaccccg	19	11	1	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr11:2950491C>T	uc001lxa.1	-	1	160	c.104G>A	c.(103-105)CGC>CAC	p.R35H		NM_003311	NP_003302	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain family A member	35	PH.				apoptosis	cytoplasm|membrane					0		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGGCTCAGGCGGTCGGAGGT	0.667													T	2950491	T	T	2950491	3	4	64	1	0	0	0	0	1	0	0	0	11849	768	27	1	358	1	PHLDA2	11	2950491	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08		2950491	132056025	16	4241											
OR52J3	119679	broad.mit.edu	37	chr11	5068409	5068409	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggtgctcattggcatctcGtatgtttacattctccgtgc	9	11	3	0	rs148600962		TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr11:5068409G>A	uc010qyv.1	+	1	654	c.654G>A	c.(652-654)TCG>TCA	p.S218S		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	218	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGGCATCTCGTATGTTTACA	0.448													A	5068409	A	A	5068409	2	1	64	1	0	0	0	0	0	0	0	1	11122	1132	40	1		1	OR52J3	11	5068409	Silent	SNP	G	TCGA-06-0750-01A-01W-0348-08	2117918	5068409	129938107	17	4242											
OR5P2	120065	broad.mit.edu	37	chr11	7818191	7818191	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgactgttgcaaagaaagccGctgaaccaagctggatggca	12	10	0	2			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr11:7818191G>A	uc001mfp.1	-	1	299	c.299C>T	c.(298-300)GCG>GTG	p.A100V		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	100	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAAGAAAGCCGCTGAACCAAG	0.483													A	7818191	A	A	7818191	3	1	64	1	0	0	0	0	1	0	0	0	11178	1087	38	1	673	1	OR5P2	11	7818191	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	2749782	7818191	127188325	18	4243											
OR5W2	390148	broad.mit.edu	37	chr11	55681318	55681318	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttccctggaaaattgcaacCgcagataagtgggaagtgca	12	8	0	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr11:55681318C>T	uc010rir.1	-	1	741	c.741G>A	c.(739-741)GCG>GCA	p.A247A		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AAATTGCAACCGCAGATAAGT	0.403													T	55681318	T	T	55681318	2	4	64	1	0	0	0	0	0	0	0	1	11185	639	23	2		2	OR5W2	11	55681318	Silent	SNP	C	TCGA-06-0750-01A-01W-0348-08	47863127	55681318	79325198	19	4244											
OR5T2	219464	broad.mit.edu	37	chr11	55999905	55999905	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaaccataggagatcagaaCaatcaggatagtgaccagct	9	9	2	3	rs146086539		TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr11:55999905C>T	uc010rjc.1	-	1	757	c.757G>A	c.(757-759)GTT>ATT	p.V253I		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	253	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAGATCAGAACAATCAGGATA	0.448													T	55999905	T	T	55999905	3	4	64	1	0	0	0	0	1	0	0	0	11182	478	17	3	321	3	OR5T2	11	55999905	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08	318587	55999905	79006611	20	4245											
PDE2A	5138	broad.mit.edu	37	chr11	72293532	72293532	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggaacgaggggtataggtgaAacttgcaaaattggagtcaa	14	4	1	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr11:72293532A>G	uc010rrc.1	-	21	2050	c.1807T>C	c.(1807-1809)TTC>CTC	p.F603L	PDE2A_uc001oso.2_Missense_Mutation_p.F582L|PDE2A_uc010rra.1_Missense_Mutation_p.F596L|PDE2A_uc001osn.2_Missense_Mutation_p.F347L|PDE2A_uc010rrb.1_Missense_Mutation_p.F594L|PDE2A_uc010rrd.1_Missense_Mutation_p.F488L	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	603					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GTATAGGTGAAACTTGCAAAA	0.537													G	72293532	G	G	72293532	3	3	64	1	0	0	0	0	1	0	0	0	11636	14	1	4	1062	4	PDE2A	11	72293532	Missense_Mutation	SNP	A	TCGA-06-0750-01A-01W-0348-08	16293627	72293532	62712984	21	4246											
OR8B4	283162	broad.mit.edu	37	chr11	124294255	124294255	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagataatggtcaatgacGttggaatcacagaaggtcag	11	7	3	3	rs146995996	byFrequency	TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr11:124294255G>A	uc010sak.1	-	1	513	c.513C>T	c.(511-513)AAC>AAT	p.N171N		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GGTCAATGACGTTGGAATCAC	0.512													A	124294255	A	A	124294255	2	1	64	1	0	0	0	0	0	0	0	1	11229	1136	40	1		1	OR8B4	11	124294255	Silent	SNP	G	TCGA-06-0750-01A-01W-0348-08	52000723	124294255	10712261	22	4247											
SRPR	6734	broad.mit.edu	37	chr11	126134309	126134309	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attgcctactaaggcttctcCtacaaacagcaccaaatcag	5	13	2	0			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr11:126134309C>A	uc001qdh.2	-	12	1702	c.1651G>T	c.(1651-1653)GGA>TGA	p.G551*	SRPR_uc010sbm.1_Nonsense_Mutation_p.G523*	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor	551					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		AAGGCTTCTCCTACAAACAGC	0.517													A	126134309	A	A	126134309	4	1	64	1	0	0	0	0	0	1	0	0	15161	690	24	5	277	5	SRPR	11	126134309	Nonsense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08	1840054	126134309	8872207	23	4248											
ZFC3H1	196441	broad.mit.edu	37	chr12	72057129	72057129	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcagacgcgtgccgcgagcGtgagaaattcctcagctgct	12	13	2	2			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr12:72057129G>A	uc001swo.2	-	1	621	c.262C>T	c.(262-264)CGC>TGC	p.R88C	ZFC3H1_uc010sts.1_Missense_Mutation_p.R88C|ZFC3H1_uc001swp.2_Missense_Mutation_p.R88C|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	88	Ser-rich.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TGCCGCGAGCGTGAGAAATTC	0.652											OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	72057129	A	A	72057129	3	1	64	1	0	0	0	0	1	0	0	0	17630	1145	40	1	5847	1	ZFC3H1	12	72057129	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08		72057129	61794766	24	4249											
NR1H4	9971	broad.mit.edu	37	chr12	100904745	100904745	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaatatatgaactcaggcGtatgccagctgagactctct	10	9	2	2	rs113431969		TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr12:100904745G>A	uc001tht.1	+	2	327	c.299G>A	c.(298-300)CGT>CAT	p.R100H	NR1H4_uc001thp.1_Missense_Mutation_p.R90H|NR1H4_uc001thq.1_Missense_Mutation_p.R90H|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Missense_Mutation_p.R90H|NR1H4_uc010svk.1_Missense_Mutation_p.R90H|NR1H4_uc001ths.1_Missense_Mutation_p.R100H	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	100					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GAACTCAGGCGTATGCCAGCT	0.522													A	100904745	A	A	100904745	3	1	64	1	0	0	0	0	1	0	0	0	10619	1145	40	1	275	1	NR1H4	12	100904745	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	28847616	100904745	32947150	25	4250											
GABRA5	2558	broad.mit.edu	37	chr15	27114460	27114460	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttctcttttgtatttccaTgaacttatccagtcactttg	4	11	2	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr15:27114460T>C	uc001zbd.1	+	4	404	c.65T>C	c.(64-66)ATG>ACG	p.M22T	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	22					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGTATTTCCATGAACTTATCC	0.388													C	27114460	C	C	27114460	3	2	64	1	0	0	0	0	1	0	0	0	6164	1464	51	4	67	4	GABRA5	15	27114460	Missense_Mutation	SNP	T	TCGA-06-0750-01A-01W-0348-08		27114460	75416932	26	4251											
CHSY1	22856	broad.mit.edu	37	chr15	101718018	101718018	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacaatctttgggtcatactGgctgaagatgattggaaaat	10	5	2	3			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr15:101718018G>A	uc002bwt.1	-	4	2467	c.1984C>T	c.(1984-1986)CAG>TAG	p.Q662*	CHSY1_uc010usd.1_Nonsense_Mutation_p.Q390*	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	662	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GGGTCATACTGGCTGAAGATG	0.428													A	101718018	A	A	101718018	4	1	64	1	0	0	0	0	0	1	0	0	3412	1357	47	3	428	3	CHSY1	15	101718018	Nonsense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	74603558	101718018	813374	27	4252											
RLTPR	146206	broad.mit.edu	37	chr16	67683416	67683417	+	Frame_Shift_Ins	INS	-	T	T													cagcgtcctactccgggcccINStagccaccaatcctaacctg							TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr16:67683416_67683417insT	uc002etn.2	+	20	1933_1934	c.1813_1814insT	c.(1813-1815)CTAfs	p.L605fs	RLTPR_uc010cel.1_Frame_Shift_Ins_p.L598fs|RLTPR_uc010vjr.1_Frame_Shift_Ins_p.L569fs	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	605	Tropomodulin-like.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		ACTCCGGGCCCTAGCCACCAAT	0.629													T	67683417	T	T	67683416	7	5	64	1	0	1	1	0	0	0	0	0	13394	680	24	0	1891	0	RLTPR	16	67683416	Frame_Shift_Ins	INS	-	TCGA-06-0750-01A-01W-0348-08		67683416	22671337	28	4253											
DPEP1	1800	broad.mit.edu	37	chr16	89704306	89704306	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatcgctgagctgctcaggaGgaactggacggaggcggagg	19	8	1	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr16:89704306G>A	uc010cin.2	+	10	1195	c.992G>A	c.(991-993)AGG>AAG	p.R331K	DPEP1_uc002fnr.3_Missense_Mutation_p.R331K|DPEP1_uc002fns.3_Missense_Mutation_p.R331K	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	331					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	CTGCTCAGGAGGAACTGGACG	0.627													A	89704306	A	A	89704306	3	1	64	1	0	0	0	0	1	0	0	0	4713	1000	35	3	1026	3	DPEP1	16	89704306	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	22020890	89704306	650447	29	4254											
FXR2	9513	broad.mit.edu	37	chr17	7495610	7495610	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcttctgagggtttagtgcGttccaggggtggcctctggc	16	9	3	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr17:7495610G>A	uc002gia.1	-	16	2115	c.1888C>T	c.(1888-1890)CGC>TGC	p.R630C	MPDU1_uc010vuc.1_Intron|SOX15_uc002ghy.1_5'Flank|SOX15_uc002ghz.1_5'Flank	NM_004860	NP_004851	P51116	FXR2_HUMAN	fragile X mental retardation syndrome related	630						cytosolic large ribosomal subunit	protein binding|RNA binding				0				READ - Rectum adenocarcinoma(115;0.17)		GGTTTAGTGCGTTCCAGGGGT	0.522													A	7495610	A	A	7495610	3	1	64	1	0	0	0	0	1	0	0	0	6116	1145	40	1	41	1	FXR2	17	7495610	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08		7495610	73699600	30	4255											
FKBP10	60681	broad.mit.edu	37	chr17	39975472	39975472	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccttccccagggacagtgatCcccccacaggcctcgctggt	10	18	0	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr17:39975472C>T	uc002hxv.2	+	5	1063	c.738C>T	c.(736-738)ATC>ATT	p.I246I	FKBP10_uc002hxw.1_5'UTR	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	246	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GGACAGTGATCCCCCCACAGG	0.607													T	39975472	T	T	39975472	2	4	64	1	0	0	0	0	0	0	0	1	5902	845	30	3		3	FKBP10	17	39975472	Silent	SNP	C	TCGA-06-0750-01A-01W-0348-08	32479862	39975472	41219738	31	4256											
NPEPPS	9520	broad.mit.edu	37	chr17	45681356	45681356	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaagtttattaccaggcattCgtgacctttctctgccccct	6	13	1	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr17:45681356C>T	uc002ilr.3	+	16	2039	c.1816C>T	c.(1816-1818)CGT>TGT	p.R606C	NPEPPS_uc010wkt.1_Missense_Mutation_p.R602C|NPEPPS_uc010wku.1_Missense_Mutation_p.R570C|NPEPPS_uc010wkv.1_Missense_Mutation_p.R160C|NPEPPS_uc002ils.1_Missense_Mutation_p.R39C	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	606					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						ACCAGGCATTCGTGACCTTTC	0.433													T	45681356	T	T	45681356	3	4	64	1	0	0	0	0	1	0	0	0	10575	884	31	2	1878	2	NPEPPS	17	45681356	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08	5705884	45681356	35513854	32	4257											
DSG1	1828	broad.mit.edu	37	chr18	28934664	28934664	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cctctgggctatggtaatgtCactgtgaccgagtcttacac	10	11	3	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr18:28934664C>T	uc002kwp.2	+	15	2717	c.2505C>T	c.(2503-2505)GTC>GTT	p.V835V	DSG1_uc010xbp.1_Silent_p.V194V	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	835	Desmoglein repeat 1.|Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			ATGGTAATGTCACTGTGACCG	0.512													T	28934664	T	T	28934664	2	4	64	1	0	0	0	0	0	0	0	1	4776	813	29	3		3	DSG1	18	28934664	Silent	SNP	C	TCGA-06-0750-01A-01W-0348-08		28934664	49142584	33	4258											
SLC14A2	8170	broad.mit.edu	37	chr18	43212315	43212315	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcagtctgtttcaccgccagGtctgccattgcctcaggact	9	14	5	0			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr18:43212315G>T	uc010dnj.2	+	6	843	c.522G>T	c.(520-522)AGG>AGT	p.R174S	SLC14A2_uc002lbb.2_Missense_Mutation_p.R174S|SLC14A2_uc002lbe.2_Missense_Mutation_p.R174S	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	174						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TCACCGCCAGGTCTGCCATTG	0.408													T	43212315	T	T	43212315	3	4	64	1	0	0	0	0	1	0	0	0	14397	1275	44	5	536	5	SLC14A2	18	43212315	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	14277651	43212315	34864933	34	4259											
MC4R	4160	broad.mit.edu	37	chr18	58038973	58038973	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agaagccatgagagccagcaTggtgaagaacatggtgatga	14	6	0	6			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr18:58038973T>A	uc002lie.1	-	1	1029	c.610A>T	c.(610-612)ATG>TTG	p.M204L		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	204	Helical; Name=5; (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				AGAGCCAGCATGGTGAAGAAC	0.498													A	58038973	A	A	58038973	3	1	64	1	0	0	0	0	1	0	0	0	9366	1464	51	5	392	5	MC4R	18	58038973	Missense_Mutation	SNP	T	TCGA-06-0750-01A-01W-0348-08	14826658	58038973	20038275	35	4260											
C18orf22	79863	broad.mit.edu	37	chr18	77796687	77796687	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaaaaaggtttggtatgaaAgtccttccttgggttctcac	10	7	1	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr18:77796687A>C	uc002lns.2	+	2	316	c.178A>C	c.(178-180)AGT>CGT	p.S60R	TXNL4A_uc010drg.2_5'Flank|C18orf22_uc010drh.2_Missense_Mutation_p.S60R|C18orf22_uc010dri.1_Intron	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	60					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		TTGGTATGAAAGTCCTTCCTT	0.378													C	77796687	C	C	77796687	3	2	64	1	0	0	0	0	1	0	0	0	1898	72	3	5	184	5	C18orf22	18	77796687	Missense_Mutation	SNP	A	TCGA-06-0750-01A-01W-0348-08	19757714	77796687	280561	36	4261											
MAP1S	55201	broad.mit.edu	37	chr19	17844106	17844106	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gcagcgcccacctggtggatGaggagttcttccagcgcgtg	15	12	1	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr19:17844106G>T	uc002nhe.1	+	6	2902	c.2893G>T	c.(2893-2895)GAG>TAG	p.E965*	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_Nonsense_Mutation_p.E213*|MAP1S_uc010xpv.1_Nonsense_Mutation_p.E939*	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	965	Necessary for association with actin (By similarity).|Necessary for interaction with RASSF1 isoform A and isoform C.|Necessary for association with microtubules.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						CCTGGTGGATGAGGAGTTCTT	0.697													T	17844106	T	T	17844106	4	4	64	1	0	0	0	0	0	1	0	0	9234	1291	45	5	2915	5	MAP1S	19	17844106	Nonsense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08		17844106	41284877	37	4262											
ZNF98	148198	broad.mit.edu	37	chr19	22574462	22574462	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atagaggagttgttaaaggcTttgccgcattcttcacactt	9	8	2	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr19:22574462T>A	uc002nqt.2	-	4	1697	c.1575A>T	c.(1573-1575)AAA>AAT	p.K525N		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	525	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TGTTAAAGGCTTTGCCGCATT	0.388													A	22574462	A	A	22574462	3	1	64	1	0	0	0	0	1	0	0	0	18200	1606	56	5	147	5	ZNF98	19	22574462	Missense_Mutation	SNP	T	TCGA-06-0750-01A-01W-0348-08	4730356	22574462	36554521	38	4263											
CD37	951	broad.mit.edu	37	chr19	49840274	49840274	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggggccctcaaggagctccGctgcctcctgggcctggtga	16	14	1	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr19:49840274G>A	uc002pnd.2	+	3	372	c.251G>A	c.(250-252)CGC>CAC	p.R84H	uc002pnb.1_Intron|CD37_uc002pnc.2_RNA|CD37_uc010yam.1_Missense_Mutation_p.R84H|CD37_uc010yan.1_Missense_Mutation_p.R16H|CD37_uc002pnf.3_Missense_Mutation_p.R56H|CD37_uc002pne.2_Missense_Mutation_p.R16H	NM_001774	NP_001765	P11049	CD37_HUMAN	CD37 antigen isoform A	84	Cytoplasmic (Potential).					integral to membrane					0		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		AAGGAGCTCCGCTGCCTCCTG	0.622													A	49840274	A	A	49840274	3	1	64	1	0	0	0	0	1	0	0	0	3008	1087	38	1	261	1	CD37	19	49840274	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	27265812	49840274	9288709	39	4264											
CST7	8530	broad.mit.edu	37	chr20	24930092	24930092	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccccatgctgcctgagaaggCactgcacggccacccccaac	9	19	0	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr20:24930092C>A	uc002wtx.1	+	1	227	c.17C>A	c.(16-18)GCA>GAA	p.A6E		NM_003650	NP_003641	O76096	CYTF_HUMAN	cystatin F	Error:Variant_position_missing_in_O76096_after_alignment					immune response	cytoplasm|extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1						CCTGAGAAGGCACTGCACGGC	0.672													A	24930092	A	A	24930092	3	1	64	1	0	0	0	0	1	0	0	0	3977	725	25	5		5	CST7	20	24930092	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08		24930092	38095428	40	4265											
C20orf185	359710	broad.mit.edu	37	chr20	31656654	31656654	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcaactcctactgttcctgCgggtgagggaagctcccacg	12	13	0	1			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr20:31656654C>T	uc002wym.1	+	10	1024	c.1024C>T	c.(1024-1026)CGG>TGG	p.R342W		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	342					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						ACTGTTCCTGCGGGTGAGGGA	0.562													T	31656654	T	T	31656654	3	4	64	1	0	0	0	0	1	0	0	0	2097	759	27	1	1062	1	C20orf185	20	31656654	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08	6726562	31656654	31368866	41	4266											
PHF20	51230	broad.mit.edu	37	chr20	34487354	34487354	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atgcaccagctgtcgacctaGaccataagtttagatgcaaa	8	10	0	2			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr20:34487354G>T	uc002xek.1	+	10	1456	c.1345G>T	c.(1345-1347)GAC>TAC	p.D449Y	PHF20_uc002xei.1_Missense_Mutation_p.D449Y|PHF20_uc010gfo.1_Missense_Mutation_p.D449Y|PHF20_uc002xej.1_Missense_Mutation_p.D333Y	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	449					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					TGTCGACCTAGACCATAAGTT	0.348													T	34487354	T	T	34487354	3	4	64	1	0	0	0	0	1	0	0	0	11831	942	33	5	1379	5	PHF20	20	34487354	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08	2830700	34487354	28538166	42	4267											
TMPRSS3	64699	broad.mit.edu	37	chr21	43803180	43803180	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagtgatgatccacaggggCgtgatgacagagcccccgca	14	12	0	5			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr21:43803180C>T	uc002zbb.2	-	8	945	c.744G>A	c.(742-744)ACG>ACA	p.T248T	TMPRSS3_uc002zay.2_5'UTR|TMPRSS3_uc002zaz.2_Silent_p.T121T|TMPRSS3_uc002zba.2_Silent_p.T121T|TMPRSS3_uc002zbc.2_Silent_p.T248T|TMPRSS3_uc002zbd.2_Silent_p.T248T	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	248	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						TCCACAGGGGCGTGATGACAG	0.602													T	43803180	T	T	43803180	2	4	64	1	0	0	0	0	0	0	0	1	16245	755	27	1		1	TMPRSS3	21	43803180	Silent	SNP	C	TCGA-06-0750-01A-01W-0348-08		43803180	4326715	43	4268											
GGT5	2687	broad.mit.edu	37	chr22	24622188	24622188	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccggccatcgatctgttggCggatgagctgggccagggtc	16	12	1	1	rs149456868		TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chr22:24622188C>T	uc002zzo.3	-	8	1502	c.1085G>A	c.(1084-1086)CGC>CAC	p.R362H	GGT5_uc002zzp.3_Missense_Mutation_p.R362H|GGT5_uc002zzr.3_Missense_Mutation_p.R330H|GGT5_uc002zzq.3_Missense_Mutation_p.R330H|GGT5_uc011ajm.1_Missense_Mutation_p.R285H|GGT5_uc011ajn.1_RNA	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	362	Extracellular (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						GATCTGTTGGCGGATGAGCTG	0.692													T	24622188	T	T	24622188	3	4	64	1	0	0	0	0	1	0	0	0	6362	768	27	1	698	1	GGT5	22	24622188	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08		24622188	26682378	44	4269											
DMD	1756	broad.mit.edu	37	chrX	32663088	32663088	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgttttagtttacctcatgaGtatgaaactggtctttcacc	7	9	3	2			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chrX:32663088G>C	uc004dda.1	-	10	1386	c.1142C>G	c.(1141-1143)ACT>AGT	p.T381S	DMD_uc004dcz.2_Missense_Mutation_p.T258S|DMD_uc004dcy.1_Missense_Mutation_p.T377S|DMD_uc004ddb.1_Missense_Mutation_p.T373S|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.T373S|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron|DMD_uc010ngr.1_Missense_Mutation_p.T92S	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	381	Spectrin 1.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TACCTCATGAGTATGAAACTG	0.353													C	32663088	C	C	32663088	3	2	64	1	0	0	0	0	1	0	0	0	4580	1029	36	5	10438	5	DMD	23	32663088	Missense_Mutation	SNP	G	TCGA-06-0750-01A-01W-0348-08		32663088	122607472	45	4270											
PCDH11X	27328	broad.mit.edu	37	chrX	91132696	91132696	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctcctggcatccagttgaCgaaagtaagtgcaatggatg	11	9	1	1	rs62621113		TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chrX:91132696C>T	uc004efk.1	+	2	2302	c.1457C>T	c.(1456-1458)ACG>ATG	p.T486M	PCDH11X_uc004efl.1_Missense_Mutation_p.T486M|PCDH11X_uc004efo.1_Missense_Mutation_p.T486M|PCDH11X_uc010nmv.1_Missense_Mutation_p.T486M|PCDH11X_uc004efm.1_Missense_Mutation_p.T486M|PCDH11X_uc004efn.1_Missense_Mutation_p.T486M|PCDH11X_uc004efh.1_Missense_Mutation_p.T486M|PCDH11X_uc004efj.1_Missense_Mutation_p.T486M	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	486	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ATCCAGTTGACGAAAGTAAGT	0.438													T	91132696	T	T	91132696	3	4	64	1	0	0	0	0	1	0	0	0	11508	536	19	1	1463	1	PCDH11X	23	91132696	Missense_Mutation	SNP	C	TCGA-06-0750-01A-01W-0348-08	58469608	91132696	64137864	46	4271											
GPRASP2	114928	broad.mit.edu	37	chrX	101971308	101971308	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attcaaacctggtctttttcAtggggttggcttccgatcca	9	10	3	0			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chrX:101971308A>G	uc004ejk.2	+	4	2845	c.1511A>G	c.(1510-1512)CAT>CGT	p.H504R	GPRASP2_uc004ejl.2_Missense_Mutation_p.H504R|GPRASP2_uc004ejm.2_Missense_Mutation_p.H504R|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	504						cytoplasm	protein binding			ovary(1)	1						GGTCTTTTTCATGGGGTTGGC	0.512													G	101971308	G	G	101971308	3	3	64	1	0	0	0	0	1	0	0	0	6723	217	8	4	1513	4	GPRASP2	23	101971308	Missense_Mutation	SNP	A	TCGA-06-0750-01A-01W-0348-08	10838612	101971308	53299252	47	4272											
PCDH11Y	83259	broad.mit.edu	37	chrY	4968500	4968500	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taactacacctactactttcAagcctgacagccctgatttg	5	13	1	2			TCGA-06-0750-01A-01W-0348-08	TCGA-06-0750-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	fc15ced3-5ed1-4f88-8789-09ec713bd613	26786497-ed7d-4242-93b7-6f0793c2c384	g.chrY:4968500A>G	uc004fqo.2	+	2	3615	c.2881A>G	c.(2881-2883)AAG>GAG	p.K961E	PCDH11Y_uc010nwg.1_Missense_Mutation_p.K950E|PCDH11Y_uc004fql.1_Missense_Mutation_p.K950E|PCDH11Y_uc004fqm.1_Missense_Mutation_p.K950E|PCDH11Y_uc004fqn.1_Missense_Mutation_p.K961E|PCDH11Y_uc004fqp.1_Missense_Mutation_p.K732E	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	961	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TACTACTTTCAAGCCTGACAG	0.458													G	4968500	G	G	4968500	3	3	64	1	0	0	0	0	1	0	0	0	11509	131	5	4	2923	4	PCDH11Y	24	4968500	Missense_Mutation	SNP	A	TCGA-06-0750-01A-01W-0348-08		4968500	54405066	48	4273											
AGRN	375790	broad.mit.edu	37	chr1	981607	981607	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccatcgcctgccgccaggGcctgcaaatctctatccaga	9	16	1	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr1:981607G>A	uc001ack.1	+	17	2923	c.2873G>A	c.(2872-2874)GGC>GAC	p.G958D		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	958	Kazal-like 9.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		TGCCGCCAGGGCCTGCAAATC	0.612													A	981607	A	A	981607	3	1	65	1	0	0	0	0	1	0	0	0	397	1203	42	3	2939	3	AGRN	1	981607	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08		981607	248269014	1	4274											
ZNF362	149076	broad.mit.edu	37	chr1	33745881	33745881	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcatctcagggatcaccaGcccccctctcctggactcca	6	20	4	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr1:33745881G>A	uc001bxc.1	+	5	676	c.506G>A	c.(505-507)AGC>AAC	p.S169N		NM_152493	NP_689706	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGGATCACCAGCCCCCCTCTC	0.677													A	33745881	A	A	33745881	3	1	65	1	0	0	0	0	1	0	0	0	17865	971	34	3	520	3	ZNF362	1	33745881	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	32764274	33745881	215504740	2	4275											
MAP7D1	55700	broad.mit.edu	37	chr1	36636835	36636835	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccaccagccatgggcccaCgggatgccagacctcctcga	10	19	0	1	rs2296266	byFrequency	TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr1:36636835C>T	uc001bzz.2	+	2	526	c.310C>T	c.(310-312)CGG>TGG	p.R104W	MAP7D1_uc001caa.2_Missense_Mutation_p.R104W|MAP7D1_uc001cab.2_Missense_Mutation_p.R104W|MAP7D1_uc001cac.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	104	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				CATGGGCCCACGGGATGCCAG	0.662													T	36636835	T	T	36636835	3	4	65	1	0	0	0	0	1	0	0	0	9267	527	19	1	316	1	MAP7D1	1	36636835	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	2890954	36636835	212613786	3	4276											
TM2D1	83941	broad.mit.edu	37	chr1	62190731	62190731	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgagacgaaccacaggacaCcaacgagtctggccgtcacg	11	14	2	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr1:62190731C>A	uc001czz.1	-	1	365	c.62G>T	c.(61-63)GGT>GTT	p.G21V		NM_032027	NP_114416	Q9BX74	TM2D1_HUMAN	beta-amyloid binding protein precursor	21					apoptosis					ovary(1)	1						CCACAGGACACCAACGAGTCT	0.657													A	62190731	A	A	62190731	3	1	65	1	0	0	0	0	1	0	0	0	15960	507	18	5	585	5	TM2D1	1	62190731	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	25553896	62190731	187059890	4	4277											
FLG	2312	broad.mit.edu	37	chr1	152282713	152282713	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agtgcctggagccgtctcctGattgttcctcatttcttgtt	9	11	3	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr1:152282713G>C	uc001ezu.1	-	3	4685	c.4649C>G	c.(4648-4650)TCA>TGA	p.S1550*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1550	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGTCTCCTGATTGTTCCTC	0.592									Ichthyosis				C	152282713	C	C	152282713	4	2	65	1	0	0	0	0	0	1	0	0	5922	1294	45	5	7540	5	FLG	1	152282713	Nonsense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	90091982	152282713	96967908	5	4278											
TMEM198	130612	broad.mit.edu	37	chr2	220414057	220414057	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtgcccatcaaacgcttcaAtggagacgtcctctccccgg	9	15	3	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr2:220414057A>G	uc002vme.2	+	5	1511	c.926A>G	c.(925-927)AAT>AGT	p.N309S	TMEM198_uc002vmf.2_Missense_Mutation_p.N309S|hsa-mir-3132|MI0014152_5'Flank	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	309						integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AAACGCTTCAATGGAGACGTC	0.627													G	220414057	G	G	220414057	3	3	65	1	0	0	0	0	1	0	0	0	16116	101	4	4	936	4	TMEM198	2	220414057	Missense_Mutation	SNP	A	TCGA-06-0875-01A-01W-0424-08		220414057	22785316	6	4279											
TGFBR2	7048	broad.mit.edu	37	chr3	30732972	30732972	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	accacgacccagaggcccgtCtcacagcccagtgtgtggca	11	16	1	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr3:30732972C>T	uc003ceo.2	+	7	1967	c.1585C>T	c.(1585-1587)CTC>TTC	p.L529F	TGFBR2_uc003cen.2_Missense_Mutation_p.L554F	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	529	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						AGAGGCCCGTCTCACAGCCCA	0.592													T	30732972	T	T	30732972	3	4	65	1	0	0	0	0	1	0	0	0	15819	913	32	3	1690	3	TGFBR2	3	30732972	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08		30732972	167289458	7	4280											
CELSR3	1951	broad.mit.edu	37	chr3	48696782	48696782	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tatatgggcattggggccttCgtcagggtccactgcagtga	14	9	1	1	rs144228630		TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr3:48696782C>T	uc003cul.2	-	1	3567	c.3286G>A	c.(3286-3288)GAA>AAA	p.E1096K	CELSR3_uc003cuf.1_Missense_Mutation_p.E1166K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1096	Extracellular (Potential).|Cadherin 8.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TTGGGGCCTTCGTCAGGGTCC	0.532													T	48696782	T	T	48696782	3	4	65	1	0	0	0	0	1	0	0	0	3223	893	31	2	6792	2	CELSR3	3	48696782	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	17963810	48696782	149325648	8	4281											
BSN	8927	broad.mit.edu	37	chr3	49699300	49699300	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtccagggcccatggggcCcaagcatccctccaagagcc	12	16	0	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr3:49699300C>T	uc003cxe.3	+	6	10136	c.10022C>T	c.(10021-10023)CCC>CTC	p.P3341L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3341					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCCATGGGGCCCAAGCATCCC	0.572													T	49699300	T	T	49699300	3	4	65	1	0	0	0	0	1	0	0	0	1530	623	22	3	10044	3	BSN	3	49699300	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	1002518	49699300	148323130	9	4282											
CLDN18	51208	broad.mit.edu	37	chr3	137717874	137717874	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gctgtggcgctcctgtgtccGagagagctctggcttcaccg	14	13	2	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr3:137717874G>A	uc003ero.1	+	1	217	c.164G>A	c.(163-165)CGA>CAA	p.R55Q		NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	55	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCCTGTGTCCGAGAGAGCTCT	0.602													A	137717874	A	A	137717874	3	1	65	1	0	0	0	0	1	0	0	0	3479	1058	37	2	166	2	CLDN18	3	137717874	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	88018574	137717874	60304556	10	4283											
ATP10D	57205	broad.mit.edu	37	chr4	47575010	47575010	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tctctattttttctataagaAtgtggtatgtaaccccagag	7	7	2	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr4:47575010A>T	uc003gxk.1	+	18	3526	c.3362A>T	c.(3361-3363)AAT>ATT	p.N1121I	ATP10D_uc003gxl.1_Missense_Mutation_p.N369I	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1121	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						TTCTATAAGAATGTGGTATGT	0.433													T	47575010	T	T	47575010	3	4	65	1	0	0	0	0	1	0	0	0	1118	101	4	5	3428	5	ATP10D	4	47575010	Missense_Mutation	SNP	A	TCGA-06-0875-01A-01W-0424-08		47575010	143579266	11	4284											
KIAA1211	57482	broad.mit.edu	37	chr4	57189704	57189704	+	Frame_Shift_Del	DEL	A	-	-													gaaagcaagccagagaggccAaacaggcagaaaagctctcc							TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr4:57189704delA	uc003hbk.2	+	9	3740	c.3349delA	c.(3349-3351)AAAfs	p.K1117fs	KIAA1211_uc010iha.2_Frame_Shift_Del_p.K1110fs	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	1117										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CAGAGAGGCCAAACAGGCAGA	0.507													-	57189704	-	-	57189704	7	5	65	1	0	1	0	1	0	0	0	0	8215	131	5	0	3371	0	KIAA1211	4	57189704	Frame_Shift_Del	DEL	A	TCGA-06-0875-01A-01W-0424-08	9614694	57189704	133964572	12	4285											
TLR2	7097	broad.mit.edu	37	chr4	154626088	154626088	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaagttgtgtcttcataagCgggacttcattcctggcaag	10	9	4	0	rs121917864		TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr4:154626088C>T	uc003inq.2	+	3	2248	c.2029C>T	c.(2029-2031)CGG>TGG	p.R677W	TLR2_uc003inr.2_Missense_Mutation_p.R677W|TLR2_uc003ins.2_Missense_Mutation_p.R677W	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	677	TIR.|Cytoplasmic (Potential).		R -> W.		cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				TCTTCATAAGCGGGACTTCAT	0.443													T	154626088	T	T	154626088	3	4	65	1	0	0	0	0	1	0	0	0	15948	759	27	1	2031	1	TLR2	4	154626088	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	97436384	154626088	36528188	13	4286											
DNAH5	1767	broad.mit.edu	37	chr5	13735337	13735337	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacaggaatttgtgctcctcGtacagccctcgggcagcata	10	12	0	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr5:13735337G>A	uc003jfd.2	-	68	11706	c.11664C>T	c.(11662-11664)TAC>TAT	p.Y3888Y	DNAH5_uc003jfc.2_Silent_p.Y56Y	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3888					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGTGCTCCTCGTACAGCCCTC	0.458									Kartagener_syndrome				A	13735337	A	A	13735337	2	1	65	1	0	0	0	0	0	0	0	1	4604	1140	40	1		1	DNAH5	5	13735337	Silent	SNP	G	TCGA-06-0875-01A-01W-0424-08		13735337	167179923	14	4287											
PCDHA12	56137	broad.mit.edu	37	chr5	140256980	140256980	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcatcctggatgaggcggaCgctccgcgccaccgcctgct	13	17	0	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr5:140256980C>T	uc003lic.2	+	1	2050	c.1923C>T	c.(1921-1923)GAC>GAT	p.D641D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.D641D	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	641	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAGGCGGACGCTCCGCGCC	0.692													T	140256980	T	T	140256980	2	4	65	1	0	0	0	0	0	0	0	1	11522	535	19	1		1	PCDHA12	5	140256980	Silent	SNP	C	TCGA-06-0875-01A-01W-0424-08	126521643	140256980	40658280	15	4288											
IL12B	3593	broad.mit.edu	37	chr5	158743755	158743755	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atagtagcggtcctgggcccGcacgctaatgctggcatttt	12	11	0	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr5:158743755G>A	uc003lxr.1	-	7	967	c.925C>T	c.(925-927)CGG>TGG	p.R309W		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	309	Fibronectin type-III.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTGGGCCCGCACGCTAATG	0.562											OREG0016989	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	158743755	A	A	158743755	3	1	65	1	0	0	0	0	1	0	0	0	7625	1086	38	1	65	1	IL12B	5	158743755	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	18486775	158743755	22171505	16	4289											
KDM1B	221656	broad.mit.edu	37	chr6	18207666	18207666	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaccacaatgaattctttgCccagtttgctggtgaccaca	9	11	1	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr6:18207666C>T	uc003nco.1	+	9	1163	c.1088C>T	c.(1087-1089)GCC>GTC	p.A363V	KDM1B_uc003ncn.1_Missense_Mutation_p.A334V	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	566					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						GAATTCTTTGCCCAGTTTGCT	0.502													T	18207666	T	T	18207666	3	4	65	1	0	0	0	0	1	0	0	0	8123	739	26	3	1039	3	KDM1B	6	18207666	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08		18207666	152907401	17	4290											
HIST1H3J	8356	broad.mit.edu	37	chr6	27858448	27858451	+	Frame_Shift_Del	DEL	GCGG	-	-													gccacggtgcctggcctgtaGcggtggggcttcttcacacc							TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr6:27858448_27858451delGCGG	uc003nka.2	-	1	120_123	c.120_123delCCGC	c.(118-123)CACCGCfs	p.H40fs	HIST1H2BO_uc003nkc.1_5'Flank	NM_003535	NP_003526	P68431	H31_HUMAN	histone cluster 1, H3j	40_41					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						CTGGCCTGTAGCGGTGGGGCTTCT	0.632													-	27858451	-	-	27858448	7	5	65	1	0	1	0	1	0	0	0	0	7164	958	34	0	291	0	HIST1H3J	6	27858448	Frame_Shift_Del	DEL	GCGG	TCGA-06-0875-01A-01W-0424-08	9650782	27858448	143256619	18	4291											
PRSS35	167681	broad.mit.edu	37	chr6	84233953	84233953	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acattccgaagggctgggcaCgaggaggcatgggggacgct	18	9	0	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr6:84233953C>T	uc003pjz.2	+	2	956	c.793C>T	c.(793-795)CGA>TGA	p.R265*	PRSS35_uc010kbm.2_Nonsense_Mutation_p.R265*	NM_153362	NP_699193	Q8N3Z0	PRS35_HUMAN	protease, serine, 35 precursor	265	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		GGGCTGGGCACGAGGAGGCAT	0.527													T	84233953	T	T	84233953	4	4	65	1	0	0	0	0	0	1	0	0	12624	528	19	1	795	1	PRSS35	6	84233953	Nonsense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	56375505	84233953	86881114	19	4292											
WISP3	8838	broad.mit.edu	37	chr6	112385979	112385979	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtagctgttgggtgcgAgttcaaccaggtacattatc	11	9	1	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr6:112385979A>G	uc003pvm.2	+	4	478	c.368A>G	c.(367-369)GAG>GGG	p.E123G	WISP3_uc003pvn.2_RNA|WISP3_uc003pvo.2_Missense_Mutation_p.E141G	NM_003880	NP_003871	O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	123					cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding				0		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		GTTGGGTGCGAGTTCAACCAG	0.458													G	112385979	G	G	112385979	3	3	65	1	0	0	0	0	1	0	0	0	17371	304	11	4	432	4	WISP3	6	112385979	Missense_Mutation	SNP	A	TCGA-06-0875-01A-01W-0424-08	28152026	112385979	58729088	20	4293											
GPR141	353345	broad.mit.edu	37	chr7	37780069	37780069	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccacttaatcagcctctactTcatagtgcttattggcgggc	8	12	3	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr7:37780069T>A	uc003tfm.1	+	1	74	c.74T>A	c.(73-75)TTC>TAC	p.F25Y	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	25	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						AGCCTCTACTTCATAGTGCTT	0.493													A	37780069	A	A	37780069	3	1	65	1	0	0	0	0	1	0	0	0	6649	1783	62	5	76	5	GPR141	7	37780069	Missense_Mutation	SNP	T	TCGA-06-0875-01A-01W-0424-08		37780069	121358594	21	4294											
TXNDC3	51314	broad.mit.edu	37	chr7	37923971	37923971	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcaaagacaagtagtattatCggaaaaagaagcacaagcac	9	7	0	2	rs144650767		TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr7:37923971C>T	uc003tfn.2	+	13	1433	c.1061C>T	c.(1060-1062)TCG>TTG	p.S354L		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	354	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GTAGTATTATCGGAAAAAGAA	0.294									Kartagener_syndrome				T	37923971	T	T	37923971	3	4	65	1	0	0	0	0	1	0	0	0	16795	893	31	2	1103	2	TXNDC3	7	37923971	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	143902	37923971	121214692	22	4295											
AMPH	273	broad.mit.edu	37	chr7	38530706	38530706	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttagcaaggacccatccaCgagtttttgatggaagtctt	10	8	1	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr7:38530706C>T	uc003tgu.2	-	5	409	c.340G>A	c.(340-342)GTG>ATG	p.V114M	AMPH_uc003tgv.2_Missense_Mutation_p.V114M	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	114	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						GACCCATCCACGAGTTTTTGA	0.403													T	38530706	T	T	38530706	3	4	65	1	0	0	0	0	1	0	0	0	588	536	19	1	1815	1	AMPH	7	38530706	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	606735	38530706	120607957	23	4296											
ABCB4	5244	broad.mit.edu	37	chr7	87035603	87035603	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcagctactctttaacttaCgtggggtaacgtctcgatga	9	9	3	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr7:87035603C>T	uc003uiv.1	-	26	3583	c.3507_splice	c.e26+1	p.H1169_splice	ABCB4_uc003uiw.1_Splice_Site_p.H1162_splice|ABCB4_uc003uix.1_Splice_Site_p.H1115_splice	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4						cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CTTTAACTTACGTGGGGTAAC	0.393													T	87035603	T	T	87035603	5	4	65	1	0	0	0	0	0	0	1	0	43	550	19	1	364	1	ABCB4	7	87035603	Splice_Site	SNP	C	TCGA-06-0875-01A-01W-0424-08	48504897	87035603	72103060	24	4297											
SAMD9L	219285	broad.mit.edu	37	chr7	92763951	92763951	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatagattcaggatcaaacTccaacacagcaaaccattta	4	11	3	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr7:92763951T>C	uc003umh.1	-	5	2550	c.1334A>G	c.(1333-1335)GAG>GGG	p.E445G	SAMD9L_uc003umj.1_Missense_Mutation_p.E445G|SAMD9L_uc003umi.1_Missense_Mutation_p.E445G|SAMD9L_uc010lfb.1_Missense_Mutation_p.E445G|SAMD9L_uc003umk.1_Missense_Mutation_p.E445G|SAMD9L_uc010lfc.1_Missense_Mutation_p.E445G|SAMD9L_uc010lfd.1_Missense_Mutation_p.E445G|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	445										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGGATCAAACTCCAACACAGC	0.343													C	92763951	C	C	92763951	3	2	65	1	0	0	0	0	1	0	0	0	13827	1551	54	4	3424	4	SAMD9L	7	92763951	Missense_Mutation	SNP	T	TCGA-06-0875-01A-01W-0424-08	5728348	92763951	66374712	25	4298											
TFPI2	7980	broad.mit.edu	37	chr7	93518519	93518519	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacactcacttgcagccgGcaaactttgggaacttctag	8	13	2	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr7:93518519G>A	uc003umy.1	-	3	363	c.288C>T	c.(286-288)TGC>TGT	p.C96C	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_Silent_p.C96C|TFPI2_uc003una.1_Silent_p.C85C|TFPI2_uc003unb.1_Silent_p.C96C|TFPI2_uc010lfg.1_Intron	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	96	BPTI/Kunitz inhibitor 2.				blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			CTTGCAGCCGGCAAACTTTGG	0.398													A	93518519	A	A	93518519	2	1	65	1	0	0	0	0	0	0	0	1	15806	1195	42	3		3	TFPI2	7	93518519	Silent	SNP	G	TCGA-06-0875-01A-01W-0424-08	754568	93518519	65620144	26	4299											
CYP3A43	64816	broad.mit.edu	37	chr7	99447306	99447306	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggattttttggatcccttttTactcttaatatgtatgtgga	8	5	1	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr7:99447306T>C	uc003urx.1	+	7	762	c.659T>C	c.(658-660)TTA>TCA	p.L220S	CYP3A43_uc003ury.1_Missense_Mutation_p.L220S|CYP3A43_uc003urz.1_Missense_Mutation_p.L220S|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Intron|CYP3A43_uc003usb.1_Silent_p.F82F	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	220			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	GATCCCTTTTTACTCTTAATA	0.204													C	99447306	C	C	99447306	3	2	65	1	0	0	0	0	1	0	0	0	4179	1764	61	4	685	4	CYP3A43	7	99447306	Missense_Mutation	SNP	T	TCGA-06-0875-01A-01W-0424-08	5928787	99447306	59691357	27	4300											
C7orf52	375607	broad.mit.edu	37	chr7	100816793	100816793	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgatcacgttcaccgactcCagcgcgatctgcggaccgag	11	15	3	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr7:100816793C>T	uc003uxy.1	-	3	560	c.321G>A	c.(319-321)CTG>CTA	p.L107L	C7orf52_uc003uxz.1_Silent_p.L107L	NM_198571	NP_940973	Q8N8M0	CG052_HUMAN	hypothetical protein LOC375607	107	N-acetyltransferase.						N-acetyltransferase activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					TCACCGACTCCAGCGCGATCT	0.736													T	100816793	T	T	100816793	2	4	65	1	0	0	0	0	0	0	0	1	2401	581	21	3		3	C7orf52	7	100816793	Silent	SNP	C	TCGA-06-0875-01A-01W-0424-08	1369487	100816793	58321870	28	4301											
CTAGE4	100128553	broad.mit.edu	37	chr7	143882703	143882703	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacctcttgctccaatcagcGgtccattgtttccagtggat	8	13	2	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr7:143882703G>A	uc010lpc.2	+	1	2156	c.2107G>A	c.(2107-2109)GGT>AGT	p.G703S		NM_198495	NP_940897	Q8IX94	CTGE4_HUMAN	CTAGE family, member 4	703	Pro-rich.					integral to membrane					0						TCCAATCAGCGGTCCATTGTT	0.502													A	143882703	A	A	143882703	3	1	65	1	0	0	0	0	1	0	0	0	3993	1116	39	2	2109	2	CTAGE4	7	143882703	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	43065910	143882703	15255960	29	4302											
ADAM32	203102	broad.mit.edu	37	chr8	39080734	39080734	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgccatgatctcgatgcacGttgtgagagtgtatttggaa	12	7	1	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr8:39080734G>A	uc003xmt.3	+	14	1747	c.1502G>A	c.(1501-1503)CGT>CAT	p.R501H	ADAM32_uc011lch.1_Missense_Mutation_p.R402H|ADAM32_uc003xmu.3_Missense_Mutation_p.R395H|ADAM32_uc003xmv.2_Missense_Mutation_p.V23I	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	501	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CTCGATGCACGTTGTGAGAGT	0.338													A	39080734	A	A	39080734	3	1	65	1	0	0	0	0	1	0	0	0	249	1145	40	1	1556	1	ADAM32	8	39080734	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08		39080734	107283288	30	4303											
IDO1	3620	broad.mit.edu	37	chr8	39785510	39785510	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acgcctgtgtgaaagctctgGtctccctgaggagctaccat	11	12	2	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr8:39785510G>C	uc003xnm.2	+	10	1132	c.1018G>C	c.(1018-1020)GTC>CTC	p.V340L	IDO1_uc003xnn.2_RNA	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	340					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	GAAAGCTCTGGTCTCCCTGAG	0.498													C	39785510	C	C	39785510	3	2	65	1	0	0	0	0	1	0	0	0	7501	1261	44	5	1056	5	IDO1	8	39785510	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	704776	39785510	106578512	31	4304											
NIPAL2	79815	broad.mit.edu	37	chr8	99215392	99215392	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taactggcaccactgttgtcGtattgtagagtttcgtggct	11	8	0	1	rs145862248	byFrequency	TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr8:99215392G>A	uc003yil.1	-	8	1080	c.824C>T	c.(823-825)ACG>ATG	p.T275M	NIPAL2_uc011lgw.1_Missense_Mutation_p.T71M|NIPAL2_uc003yim.1_Missense_Mutation_p.T275M	NM_024759	NP_079035	Q9H841	NPAL2_HUMAN	NIPA-like domain containing 2	275						integral to membrane					0						CACTGTTGTCGTATTGTAGAG	0.393													A	99215392	A	A	99215392	3	1	65	1	0	0	0	0	1	0	0	0	10425	1145	40	1	302	1	NIPAL2	8	99215392	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	59429882	99215392	47148630	32	4305											
KANK1	23189	broad.mit.edu	37	chr9	730069	730069	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggcaattatttgggatataCctgtaagtgtgggggccttc	13	6	0	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr9:730069C>G	uc003zgl.1	+	8	3366	c.2717C>G	c.(2716-2718)ACC>AGC	p.T906S	KANK1_uc003zgm.2_Missense_Mutation_p.T906S|KANK1_uc003zgn.1_Missense_Mutation_p.T906S|KANK1_uc003zgs.1_Missense_Mutation_p.T748S|KANK1_uc010mgx.1_5'Flank|KANK1_uc010mgy.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	906					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TTGGGATATACCTGTAAGTGT	0.473													G	730069	G	G	730069	3	3	65	1	0	0	0	0	1	0	0	0	7976	507	18	5	2727	5	KANK1	9	730069	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08		730069	140483362	33	4306											
RUSC2	9853	broad.mit.edu	37	chr9	35560384	35560384	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaagaagaggagacagaagaGgtggcagaggcagccggggg	21	5	0	6			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr9:35560384G>T	uc003zww.2	+	10	4002	c.3747G>T	c.(3745-3747)GAG>GAT	p.E1249D	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.E1249D	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1249	Poly-Glu.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			agacagaagaggtggcagagg	0.512													T	35560384	T	T	35560384	3	4	65	1	0	0	0	0	1	0	0	0	13751	991	35	5	3781	5	RUSC2	9	35560384	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	34830315	35560384	105653047	34	4307											
TMEM2	23670	broad.mit.edu	37	chr9	74305126	74305126	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccacaacaaggaggaggaCgcctgcacttcggaaggtaa	12	10	0	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr9:74305126C>T	uc011lsa.1	-	22	4273	c.3733G>A	c.(3733-3735)GTC>ATC	p.V1245I	TMEM2_uc011lrz.1_Missense_Mutation_p.V238I|TMEM2_uc010mos.2_Missense_Mutation_p.V1182I|TMEM2_uc011lsb.1_RNA|TMEM2_uc004aik.2_Missense_Mutation_p.V79I	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1245						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AGGAGGAGGACGCCTGCACTT	0.453													T	74305126	T	T	74305126	3	4	65	1	0	0	0	0	1	0	0	0	16118	536	19	1	430	1	TMEM2	9	74305126	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	38744742	74305126	66908305	35	4308											
TMC1	117531	broad.mit.edu	37	chr9	75387401	75387401	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caattggatggatgaatttcAggttgccgctctcctatttt	9	8	2	1	rs111839361		TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr9:75387401A>T	uc004aiz.1	+	13	1354	c.814A>T	c.(814-816)AGG>TGG	p.R272W	TMC1_uc010moz.1_Missense_Mutation_p.R230W|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.R126W|TMC1_uc010mpa.1_Missense_Mutation_p.R126W	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	272	Extracellular (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						GATGAATTTCAGGTTGCCGCT	0.398													T	75387401	T	T	75387401	3	4	65	1	0	0	0	0	1	0	0	0	15981	179	7	5	848	5	TMC1	9	75387401	Missense_Mutation	SNP	A	TCGA-06-0875-01A-01W-0424-08	1082275	75387401	65826030	36	4309											
AGPAT2	10555	broad.mit.edu	37	chr9	139568283	139568283	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agatgtggaggaaggtggtcCtcatggcccggtggcaggtg	19	7	1	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr9:139568283C>A	uc004cii.1	-	6	860	c.758G>T	c.(757-759)AGG>ATG	p.R253M	AGPAT2_uc004cij.1_Missense_Mutation_p.R221M	NM_006412	NP_006403	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	253					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GAAGGTGGTCCTCATGGCCCG	0.682													A	139568283	A	A	139568283	3	1	65	1	0	0	0	0	1	0	0	0	387	681	24	5	82	5	AGPAT2	9	139568283	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	64180882	139568283	1645148	37	4310											
PTEN	5728	broad.mit.edu	37	chr10	89717712	89717712	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtactttgagttccctcagcCgttacctgtgtgtggtgata	11	9	1	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr10:89717712C>T	uc001kfb.2	+	8	1768	c.737C>T	c.(736-738)CCG>CTG	p.P246L		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	246	C2 tensin-type.		P -> L (in CD and BZS).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.P246L(6)|p.R55fs*1(4)|p.P246fs*10(3)|p.L247fs*10(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.L247fs*11(1)|p.L247fs*12(1)|p.G165_*404del(1)|p.?(1)|p.F243fs*9(1)|p.P246fs*11(1)|p.P246_L247insGP(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTCCCTCAGCCGTTACCTGTG	0.418		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89717712	T	T	89717712	3	4	65	1	0	0	0	0	1	0	0	0	12738	652	23	2	763	2	PTEN	10	89717712	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08		89717712	45817035	38	4311											
PTEN	5728	broad.mit.edu	37	chr10	89720659	89720659	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttttttttaggacaaaatGtttcacttttgggtaaatac	6	4	1	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr10:89720659G>A	uc001kfb.2	+	9	1841	c.810G>A	c.(808-810)ATG>ATA	p.M270I		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	270	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.D268_F279>VGQNVSLLGKYI(2)|p.G165_*404del(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGGACAAAATGTTTCACTTTT	0.239		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89720659	A	A	89720659	3	1	65	1	0	0	0	0	1	0	0	0	12738	1377	48	3	840	3	PTEN	10	89720659	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	2947	89720659	45814088	39	4312											
MRGPRE	116534	broad.mit.edu	37	chr11	3249621	3249621	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacacaggtggtcaggtggcGtgggcggcggcacgagtacc	18	11	1	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr11:3249621G>A	uc001lxq.3	-	2	716	c.406C>T	c.(406-408)CGC>TGC	p.R136C		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	136	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTCAGGTGGCGTGGGCGGCGG	0.692													A	3249621	A	A	3249621	3	1	65	1	0	0	0	0	1	0	0	0	9764	1145	40	1	533	1	MRGPRE	11	3249621	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08		3249621	131756895	40	4313											
MRGPRX2	117194	broad.mit.edu	37	chr11	19077538	19077538	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtgtctggggcggcggcagcGataccagatgggccacagga	18	10	1	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr11:19077538G>A	uc001mph.2	-	2	500	c.412C>T	c.(412-414)CGC>TGC	p.R138C		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	138	Cytoplasmic (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						CGGCGGCAGCGATACCAGATG	0.617													A	19077538	A	A	19077538	3	1	65	1	0	0	0	0	1	0	0	0	9767	1058	37	2	584	2	MRGPRX2	11	19077538	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	15827917	19077538	115928978	41	4314											
MAPK8IP1	9479	broad.mit.edu	37	chr11	45925671	45925671	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccggggtgtctttcctgcctAttacgccatcgaggtcacca	10	14	2	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr11:45925671A>G	uc001nbr.2	+	7	1795	c.1625A>G	c.(1624-1626)TAT>TGT	p.Y542C		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	542	SH3.				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity	p.Y542C(1)		ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		TTTCCTGCCTATTACGCCATC	0.602													G	45925671	G	G	45925671	3	3	65	1	0	0	0	0	1	0	0	0	9284	449	16	4	1651	4	MAPK8IP1	11	45925671	Missense_Mutation	SNP	A	TCGA-06-0875-01A-01W-0424-08	26848133	45925671	89080845	42	4315											
OR5R1	219479	broad.mit.edu	37	chr11	56185215	56185215	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgggccacagtaagtcagaCggaaagtgataacggtgtgg	15	6	1	2	rs138983419	byFrequency	TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr11:56185215C>T	uc010rji.1	-	1	494	c.494G>A	c.(493-495)CGT>CAT	p.R165H		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTAAGTCAGACGGAAAGTGAT	0.438													T	56185215	T	T	56185215	3	4	65	1	0	0	0	0	1	0	0	0	11180	536	19	1	482	1	OR5R1	11	56185215	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	10259544	56185215	78821301	43	4316											
LRRC55	219527	broad.mit.edu	37	chr11	56950146	56950146	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcgaaaccggatccagcGctgtacagcaggtaatagag	13	10	0	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr11:56950146G>A	uc001njl.1	+	1	926	c.779G>A	c.(778-780)CGC>CAC	p.R260H		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	230	LRRCT.					integral to membrane					0						CGGATCCAGCGCTGTACAGCA	0.607													A	56950146	A	A	56950146	3	1	65	1	0	0	0	0	1	0	0	0	9011	1087	38	1	781	1	LRRC55	11	56950146	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	764931	56950146	78056370	44	4317											
RNF169	254225	broad.mit.edu	37	chr11	74546969	74546969	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggaacagatctttcaggagCggcagatcaaaaagaccctt	11	9	3	3			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr11:74546969C>T	uc001ovl.3	+	6	1334	c.1321C>T	c.(1321-1323)CGG>TGG	p.R441W	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	441							zinc ion binding			ovary(1)	1						CTTTCAGGAGCGGCAGATCAA	0.478													T	74546969	T	T	74546969	3	4	65	1	0	0	0	0	1	0	0	0	13460	759	27	1	1343	1	RNF169	11	74546969	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	17596823	74546969	60459547	45	4318											
C12orf4	57102	broad.mit.edu	37	chr12	4643363	4643363	+	Nonsense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgtactcgccagctgatgtAaatctacttcacctgatttc	6	11	2	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr12:4643363A>C	uc001qms.2	-	3	372	c.284T>G	c.(283-285)TTA>TGA	p.L95*	C12orf4_uc001qmt.2_Nonsense_Mutation_p.L95*	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	95											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CAGCTGATGTAAATCTACTTC	0.393													C	4643363	C	C	4643363	4	2	65	1	0	0	0	0	0	1	0	0	1685	372	13	5	1422	5	C12orf4	12	4643363	Nonsense_Mutation	SNP	A	TCGA-06-0875-01A-01W-0424-08		4643363	129208532	46	4319											
CLSTN3	9746	broad.mit.edu	37	chr12	7295764	7295764	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtctggggcccaggtccaCgtgaacccctcacagtccct	11	16	2	1	rs143198009	byFrequency	TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr12:7295764C>T	uc001qsr.2	+	12	1982	c.1704C>T	c.(1702-1704)CAC>CAT	p.H568H	CLSTN3_uc001qss.2_Silent_p.H580H	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	568	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						CCCAGGTCCACGTGAACCCCT	0.612													T	7295764	T	T	7295764	2	4	65	1	0	0	0	0	0	0	0	1	3563	535	19	1		1	CLSTN3	12	7295764	Silent	SNP	C	TCGA-06-0875-01A-01W-0424-08	2652401	7295764	126556131	47	4320											
PPP1CC	5501	broad.mit.edu	37	chr12	111168342	111168342	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaaagtacttacattcatcaTaaaatccataaattctgttg	3	7	3	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr12:111168342T>A	uc001tru.2	-	3	655	c.410A>T	c.(409-411)TAT>TTT	p.Y137F		NM_002710	NP_002701	P36873	PP1G_HUMAN	protein phosphatase 1, catalytic subunit, gamma	137					cell division|glycogen metabolic process|mitotic prometaphase|triglyceride catabolic process	cleavage furrow|condensed chromosome kinetochore|cytosol|midbody|MLL5-L complex|nuclear speck|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein kinase binding|protein serine/threonine phosphatase activity			lung(2)|central_nervous_system(1)	3						ACATTCATCATAAAATCCATA	0.308													A	111168342	A	A	111168342	3	1	65	1	0	0	0	0	1	0	0	0	12351	1406	49	5	581	5	PPP1CC	12	111168342	Missense_Mutation	SNP	T	TCGA-06-0875-01A-01W-0424-08	103872578	111168342	22683553	48	4321											
DNAH10	196385	broad.mit.edu	37	chr12	124416577	124416577	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccctaatatctggagaagGcttgctcctgacaccttaaa	7	11	1	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr12:124416577G>A	uc001uft.3	+	75	12889	c.12864G>A	c.(12862-12864)AGG>AGA	p.R4288R	DNAH10_uc001ufu.3_Silent_p.R201R	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4288					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCTGGAGAAGGCTTGCTCCTG	0.493													A	124416577	A	A	124416577	2	1	65	1	0	0	0	0	0	0	0	1	4598	1194	42	3		3	DNAH10	12	124416577	Silent	SNP	G	TCGA-06-0875-01A-01W-0424-08	13248235	124416577	9435318	49	4322											
MDGA2	161357	broad.mit.edu	37	chr14	47351248	47351248	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaatgaaaggctacttaccActatatttgatcacacgaat	5	8	1	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr14:47351248A>G	uc001wwj.3	-	11	2404	c.2208T>C	c.(2206-2208)AGT>AGC	p.S736S	MDGA2_uc001wwh.3_5'UTR|MDGA2_uc001wwi.3_Silent_p.S507S|MDGA2_uc010ani.2_Silent_p.S296S	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	736					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GCTACTTACCACTATATTTGA	0.313													G	47351248	G	G	47351248	2	3	65	1	0	0	0	0	0	0	0	1	9407	173	6	4		4	MDGA2	14	47351248	Silent	SNP	A	TCGA-06-0875-01A-01W-0424-08		47351248	59998292	50	4323											
CDKL1	8814	broad.mit.edu	37	chr14	50808934	50808934	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctggcttcacgtctctatGtatgcactagtgtaacaaat	7	9	3	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr14:50808934G>A	uc010anu.1	-	17	2386	c.2386C>T	c.(2386-2388)CAT>TAT	p.H796Y	CDKL1_uc001wxz.2_Missense_Mutation_p.H125Y	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	124	Protein kinase.					cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					ACGTCTCTATGTATGCACTAG	0.333													A	50808934	A	A	50808934	3	1	65	1	0	0	0	0	1	0	0	0	3153	1377	48	3	727	3	CDKL1	14	50808934	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	3457686	50808934	56540606	51	4324											
NIN	51199	broad.mit.edu	37	chr14	51196324	51196324	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctgcctgcagcagctggcGttgaagctgcagaaactgct	12	11	1	2	rs144624455	by1000genomes	TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr14:51196324G>A	uc001wym.2	-	29	6186	c.5995C>T	c.(5995-5997)CGC>TGC	p.R1999C	NIN_uc001wyi.2_Missense_Mutation_p.R1999C|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.R1286C|NIN_uc010tqp.1_Missense_Mutation_p.R2005C|NIN_uc001wyo.2_Missense_Mutation_p.R1999C|NIN_uc001wyn.2_RNA	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1999	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					AGCAGCTGGCGTTGAAGCTGC	0.567			T	PDGFRB	MPD								A	51196324	A	A	51196324	3	1	65	1	0	0	0	0	1	0	0	0	10417	1145	40	1	566	1	NIN	14	51196324	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	387390	51196324	56153216	52	4325											
AK7	122481	broad.mit.edu	37	chr14	96949427	96949427	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaaattatggtttaacagaCgaagaaaaggcagaagagga	12	4	0	4			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr14:96949427C>T	uc001yfn.2	+	16	1889	c.1845C>T	c.(1843-1845)GAC>GAT	p.D615D		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	615	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GTTTAACAGACGAAGAAAAGG	0.507													T	96949427	T	T	96949427	2	4	65	1	0	0	0	0	0	0	0	1	444	535	19	1		1	AK7	14	96949427	Silent	SNP	C	TCGA-06-0875-01A-01W-0424-08	45753103	96949427	10400113	53	4326											
NIPA1	123606	broad.mit.edu	37	chr15	23048832	23048832	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caagctcctattgcaatctaGtctgttttcatattagattt	5	8	3	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr15:23048832G>T	uc001yvc.2	-	5	1012	c.987C>A	c.(985-987)GAC>GAA	p.D329E	NIPA1_uc001yvd.2_Missense_Mutation_p.D159E|NIPA1_uc001yve.2_Missense_Mutation_p.D254E	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	329	Cytoplasmic (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		TTGCAATCTAGTCTGTTTTCA	0.453													T	23048832	T	T	23048832	3	4	65	1	0	0	0	0	1	0	0	0	10422	1020	36	5	6	5	NIPA1	15	23048832	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08		23048832	79482560	54	4327											
AKAP13	11214	broad.mit.edu	37	chr15	86270682	86270682	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaatgttggacaccagagccCgagaattaaaaggtgaggca	12	7	0	3			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr15:86270682C>G	uc002blv.1	+	29	7245	c.7075C>G	c.(7075-7077)CGA>GGA	p.R2359G	AKAP13_uc002blu.1_Missense_Mutation_p.R2363G|AKAP13_uc010bnf.1_Missense_Mutation_p.R980G|AKAP13_uc002blw.1_Missense_Mutation_p.R824G|AKAP13_uc002blx.1_Missense_Mutation_p.R604G	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2359	Interaction with ESR1.|Potential.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						CACCAGAGCCCGAGAATTAAA	0.448													G	86270682	G	G	86270682	3	3	65	1	0	0	0	0	1	0	0	0	449	644	23	5	7255	5	AKAP13	15	86270682	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	63221850	86270682	16260710	55	4328											
ACAN	176	broad.mit.edu	37	chr15	89417650	89417650	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctagccaccacctacaaaCgcagactacagaagcggagc	8	15	0	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr15:89417650C>T	uc010upo.1	+	18	7905	c.7531C>T	c.(7531-7533)CGC>TGC	p.R2511C	ACAN_uc010upp.1_Missense_Mutation_p.R2412C|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2511					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CACCTACAAACGCAGACTACA	0.612													T	89417650	T	T	89417650	3	4	65	1	0	0	0	0	1	0	0	0	117	536	19	1	7597	1	ACAN	15	89417650	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	3146968	89417650	13113742	56	4329											
CLCN7	1186	broad.mit.edu	37	chr16	1507256	1507256	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacaagatttcaactcaccTtgaaatctcgtttcagtgac	5	11	4	3			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr16:1507256T>C	uc002clv.2	-	9	931	c.821A>G	c.(820-822)AAG>AGG	p.K274R	CLCN7_uc002clw.2_Missense_Mutation_p.K250R	NM_001287	NP_001278	P51798	CLCN7_HUMAN	chloride channel 7 isoform a	274						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Hepatocellular(780;0.0893)				TCAACTCACCTTGAAATCTCG	0.592													C	1507256	C	C	1507256	3	2	65	1	0	0	0	0	1	0	0	0	3468	1623	56	4	1664	4	CLCN7	16	1507256	Missense_Mutation	SNP	T	TCGA-06-0875-01A-01W-0424-08		1507256	88847497	57	4330											
COG4	25839	broad.mit.edu	37	chr16	70551628	70551628	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tgctttgcatctccctcaatCagctgcagattaggactgga	9	11	3	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr16:70551628C>G	uc002ezc.2	-	3	281	c.270G>C	c.(268-270)CTG>CTC	p.L90L	COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Silent_p.L90L|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	86	Interacts with STX5.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				CTCCCTCAATCAGCTGCAGAT	0.453													G	70551628	G	G	70551628	2	3	65	1	0	0	0	0	0	0	0	1	3660	813	29	5		5	COG4	16	70551628	Silent	SNP	C	TCGA-06-0875-01A-01W-0424-08	69044372	70551628	19803125	58	4331											
TAT	6898	broad.mit.edu	37	chr16	71603782	71603782	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtacatagccccagaagggCggactggccggagtccaggg	17	11	0	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr16:71603782C>T	uc002fap.2	-	10	1199	c.1100G>A	c.(1099-1101)CGC>CAC	p.R367H		NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	367					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CCCAGAAGGGCGGACTGGCCG	0.512													T	71603782	T	T	71603782	3	4	65	1	0	0	0	0	1	0	0	0	15587	768	27	1	276	1	TAT	16	71603782	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	1052154	71603782	18750971	59	4332											
KARS	3735	broad.mit.edu	37	chr16	75665416	75665416	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gggtggggtgaagtcaacatCgtaggcttggccctctgggc	17	9	2	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr16:75665416C>T	uc002feq.2	-	9	1198	c.1150G>A	c.(1150-1152)GAT>AAT	p.D384N	KARS_uc002fer.2_Missense_Mutation_p.D412N|KARS_uc002fes.2_Missense_Mutation_p.D228N	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	384					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	AAGTCAACATCGTAGGCTTGG	0.517													T	75665416	T	T	75665416	3	4	65	1	0	0	0	0	1	0	0	0	7980	884	31	2	667	2	KARS	16	75665416	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	4061634	75665416	14689337	60	4333											
USP10	9100	broad.mit.edu	37	chr16	84812553	84812553	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggccattacactacagacgtCttccagatcggtctgaatgg	10	11	2	3			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr16:84812553C>A	uc002fii.2	+	14	2404	c.2262C>A	c.(2260-2262)GTC>GTA	p.V754V	USP10_uc010voe.1_Silent_p.V758V|USP10_uc010vof.1_Silent_p.V316V|USP10_uc002fij.2_Silent_p.V280V	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	754					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						CTACAGACGTCTTCCAGATCG	0.567													A	84812553	A	A	84812553	2	1	65	1	0	0	0	0	0	0	0	1	17038	900	32	5		5	USP10	16	84812553	Silent	SNP	C	TCGA-06-0875-01A-01W-0424-08	9147137	84812553	5542200	61	4334											
WSCD1	23302	broad.mit.edu	37	chr17	5991317	5991317	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccctttctgcaggcacctaCattggatgcttcagtgacga	9	12	2	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr17:5991317C>T	uc010cli.2	+	3	814	c.435C>T	c.(433-435)TAC>TAT	p.Y145Y	WSCD1_uc002gcn.2_Silent_p.Y145Y|WSCD1_uc002gco.2_Silent_p.Y145Y|WSCD1_uc010clj.2_Intron	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	145	WSC 1.					integral to membrane	sulfotransferase activity				0						CAGGCACCTACATTGGATGCT	0.537													T	5991317	T	T	5991317	2	4	65	1	0	0	0	0	0	0	0	1	17403	489	17	3		3	WSCD1	17	5991317	Silent	SNP	C	TCGA-06-0875-01A-01W-0424-08		5991317	75203893	62	4335											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	9	16	3	0	rs28934574		TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577094	A	A	7577094	3	1	65	1	0	0	0	0	1	0	0	0	16378	1115	39	2	442	2	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	1585777	7577094	73618116	63	4336											
SLC13A2	9058	broad.mit.edu	37	chr17	26816246	26816246	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcaggaggcctactgcgcGtatgccatcatcctcatggc	11	14	2	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr17:26816246G>A	uc002hbh.2	+	2	184	c.117G>A	c.(115-117)GCG>GCA	p.A39A	SLC13A2_uc010wal.1_Intron|SLC13A2_uc010wam.1_5'UTR|SLC13A2_uc010wan.1_Silent_p.A39A|SLC13A2_uc010wao.1_Intron|SLC13A2_uc002hbi.2_5'UTR	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	39						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CCTACTGCGCGTATGCCATCA	0.612													A	26816246	A	A	26816246	2	1	65	1	0	0	0	0	0	0	0	1	14392	1132	40	1		1	SLC13A2	17	26816246	Silent	SNP	G	TCGA-06-0875-01A-01W-0424-08	19239152	26816246	54378964	64	4337											
SLC16A6	9120	broad.mit.edu	37	chr17	66267054	66267054	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagctgcagaagacatcttcTcaatgcccacgacatcatcc	6	15	3	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr17:66267054T>G	uc002jgz.1	-	5	1435	c.1247A>C	c.(1246-1248)GAG>GCG	p.E416A	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Missense_Mutation_p.E416A	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	416	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	AGACATCTTCTCAATGCCCAC	0.458													G	66267054	G	G	66267054	3	3	65	1	0	0	0	0	1	0	0	0	14412	1551	54	5	332	5	SLC16A6	17	66267054	Missense_Mutation	SNP	T	TCGA-06-0875-01A-01W-0424-08	39450808	66267054	14928156	65	4338											
GPS1	2873	broad.mit.edu	37	chr17	80014960	80014960	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaagggagccagggggagcTgactccagccaacagccagt	15	11	0	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr17:80014960T>C	uc002kdl.1	+	13	1478	c.1433T>C	c.(1432-1434)CTG>CCG	p.L478P	GPS1_uc002kdk.1_Missense_Mutation_p.L514P|GPS1_uc010dij.1_Missense_Mutation_p.L513P|GPS1_uc002kdm.1_Missense_Mutation_p.L458P|GPS1_uc002kdn.1_Missense_Mutation_p.L474P|GPS1_uc002kdo.1_Missense_Mutation_p.L477P|GPS1_uc010wvh.1_Missense_Mutation_p.L470P	NM_004127	NP_004118	Q13098	CSN1_HUMAN	G protein pathway suppressor 1 isoform 2	478					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			CAGGGGGAGCTGACTCCAGCC	0.677													C	80014960	C	C	80014960	3	2	65	1	0	0	0	0	1	0	0	0	6732	1580	55	4	1640	4	GPS1	17	80014960	Missense_Mutation	SNP	T	TCGA-06-0875-01A-01W-0424-08	13747906	80014960	1180250	66	4339											
CIDEA	1149	broad.mit.edu	37	chr18	12262928	12262928	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatgacaggagcagccggcGtggggtgatggcaagcagcc	17	11	0	2	rs149949331	byFrequency	TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr18:12262928G>A	uc002kqt.3	+	2	208	c.143G>A	c.(142-144)CGT>CAT	p.R48H	CIDEA_uc002kqu.3_Missense_Mutation_p.R82H|CIDEA_uc010dlc.2_RNA	NM_001279	NP_001270	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a isoform	48	CIDE-N.				DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			ovary(1)|central_nervous_system(1)	2						AGCAGCCGGCGTGGGGTGATG	0.622													A	12262928	A	A	12262928	3	1	65	1	0	0	0	0	1	0	0	0	3425	1145	40	1	293	1	CIDEA	18	12262928	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08		12262928	65814320	67	4340											
MUC16	94025	broad.mit.edu	37	chr19	9046404	9046404	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actagtgatctgtgaagtcaCcatctctggtgcaccaggtg	11	10	3	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr19:9046404C>T	uc002mkp.2	-	5	35431	c.35227G>A	c.(35227-35229)GTG>ATG	p.V11743M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11745	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTGAAGTCACCATCTCTGGT	0.502													T	9046404	T	T	9046404	3	4	65	1	0	0	0	0	1	0	0	0	9973	507	18	3	8616	3	MUC16	19	9046404	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08		9046404	50082579	68	4341											
HPN	3249	broad.mit.edu	37	chr19	35556818	35556818	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaggacagcatctctcggaCgccacgttggcggctgtgtg	15	11	1	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr19:35556818C>T	uc002nxq.1	+	13	1342	c.1097C>T	c.(1096-1098)ACG>ATG	p.T366M	HPN_uc002nxr.1_Missense_Mutation_p.T366M|HPN_uc002nxs.1_Missense_Mutation_p.T208M|HPN_uc010xsh.1_Missense_Mutation_p.T335M|HPN_uc002nxt.1_Missense_Mutation_p.T250M|LOC100128675_uc010xsi.1_Intron	NM_002151	NP_002142	P05981	HEPS_HUMAN	hepsin	366	Extracellular (Potential).|Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	ATCTCTCGGACGCCACGTTGG	0.632													T	35556818	T	T	35556818	3	4	65	1	0	0	0	0	1	0	0	0	7336	536	19	1	1139	1	HPN	19	35556818	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	26510414	35556818	23572165	69	4342											
NUCB1	4924	broad.mit.edu	37	chr19	49414468	49414468	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acctggaccctcagaaccagCatacattcgaggcccgcgac	9	16	1	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr19:49414468C>G	uc002plb.3	+	5	511	c.439C>G	c.(439-441)CAT>GAT	p.H147D	NUCB1_uc002pla.2_Missense_Mutation_p.H147D|NUCB1_uc002plc.2_Missense_Mutation_p.H147D	NM_006184	NP_006175	Q02818	NUCB1_HUMAN	nucleobindin 1 precursor	147						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding				0		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		TCAGAACCAGCATACATTCGA	0.552													G	49414468	G	G	49414468	3	3	65	1	0	0	0	0	1	0	0	0	10718	710	25	5	453	5	NUCB1	19	49414468	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08	13857650	49414468	9714515	70	4343											
ZNF264	9422	broad.mit.edu	37	chr19	57722987	57722987	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttcaaggattggacaggaGcaagtctctccaggagatag	13	7	2	1			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr19:57722987G>A	uc002qob.2	+	4	935	c.522G>A	c.(520-522)GAG>GAA	p.E174E		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		TTGGACAGGAGCAAGTCTCTC	0.463													A	57722987	A	A	57722987	2	1	65	1	0	0	0	0	0	0	0	1	17801	962	34	3		3	ZNF264	19	57722987	Silent	SNP	G	TCGA-06-0875-01A-01W-0424-08	8308519	57722987	1405996	71	4344											
CHGB	1114	broad.mit.edu	37	chr20	5904212	5904212	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacagaaattatctcaactaCggtgaggaaggagccccagg	12	9	1	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr20:5904212C>T	uc002wmg.2	+	4	1728	c.1422C>T	c.(1420-1422)TAC>TAT	p.Y474Y	CHGB_uc010zqz.1_Silent_p.Y157Y	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	474						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						ATCTCAACTACGGTGAGGAAG	0.507													T	5904212	T	T	5904212	2	4	65	1	0	0	0	0	0	0	0	1	3339	547	19	1		1	CHGB	20	5904212	Silent	SNP	C	TCGA-06-0875-01A-01W-0424-08		5904212	57121308	72	4345											
TRPM2	7226	broad.mit.edu	37	chr21	45825917	45825917	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aagatcatcattgtgaagcgGatggtaagggggcgggggca	18	5	2	2			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chr21:45825917G>A	uc002zet.1	+	19	3000	c.2787G>A	c.(2785-2787)CGG>CGA	p.R929R	TRPM2_uc002zeu.1_Silent_p.R929R|TRPM2_uc002zew.1_Silent_p.R929R|TRPM2_uc010gpt.1_Silent_p.R929R|TRPM2_uc002zex.1_Silent_p.R715R|TRPM2_uc002zey.1_Silent_p.R442R	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	929	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTGTGAAGCGGATGGTAAGGG	0.627													A	45825917	A	A	45825917	2	1	65	1	0	0	0	0	0	0	0	1	16583	1161	41	3		3	TRPM2	21	45825917	Silent	SNP	G	TCGA-06-0875-01A-01W-0424-08		45825917	2303978	73	4346											
ASB11	140456	broad.mit.edu	37	chrX	15307657	15307657	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtttcttcacacagtctacCctctggtaggtgcaggccac	9	13	4	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chrX:15307657C>A	uc004cwp.1	-	5	624	c.624G>T	c.(622-624)AGG>AGT	p.R208S	ASB11_uc004cwo.1_Missense_Mutation_p.R187S|ASB11_uc010nes.1_RNA|ASB11_uc010net.1_Missense_Mutation_p.R191S	NM_080873	NP_543149	Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box-containing protein	208	ANK 5.				intracellular signal transduction					breast(2)|skin(1)	3	Hepatocellular(33;0.183)					CACAGTCTACCCTCTGGTAGG	0.408													A	15307657	A	A	15307657	3	1	65	1	0	0	0	0	1	0	0	0	1015	622	22	5	359	5	ASB11	23	15307657	Missense_Mutation	SNP	C	TCGA-06-0875-01A-01W-0424-08		15307657	139962903	74	4347											
GRPR	2925	broad.mit.edu	37	chrX	16170433	16170433	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtgtttgtgggcctgttcGccttctgctggctccccaat	12	12	1	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chrX:16170433G>A	uc004cxj.2	+	3	1473	c.820G>A	c.(820-822)GCC>ACC	p.A274T		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	274	Helical; Name=6; (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					GGGCCTGTTCGCCTTCTGCTG	0.537													A	16170433	A	A	16170433	3	1	65	1	0	0	0	0	1	0	0	0	6808	1087	38	1	830	1	GRPR	23	16170433	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	862776	16170433	139100127	75	4348											
FTHL17	53940	broad.mit.edu	37	chrX	31089888	31089888	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggcatgctccattttgtcGtccgacaggcgcaggaagta	13	10	0	0			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chrX:31089888G>A	uc004dcl.1	-	1	286	c.183C>T	c.(181-183)GAC>GAT	p.D61D		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	61	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0						CCATTTTGTCGTCCGACAGGC	0.577													A	31089888	A	A	31089888	2	1	65	1	0	0	0	0	0	0	0	1	6083	1136	40	1		1	FTHL17	23	31089888	Silent	SNP	G	TCGA-06-0875-01A-01W-0424-08	14919455	31089888	124180672	76	4349											
PAGE2B	389860	broad.mit.edu	37	chrX	55103027	55103027	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagcccactgaggaaaaacGtcaagaagaggaaccaccaa	11	10	1	3			TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chrX:55103027G>A	uc004due.2	+	3	162	c.110G>A	c.(109-111)CGT>CAT	p.R37H		NM_001015038	NP_001015038	Q5JRK9	GGEE3_HUMAN	P antigen family, member 2B	37											0						GAGGAAAAACGTCAAGAAGAG	0.443													A	55103027	A	A	55103027	3	1	65	1	0	0	0	0	1	0	0	0	11391	1145	40	1	116	1	PAGE2B	23	55103027	Missense_Mutation	SNP	G	TCGA-06-0875-01A-01W-0424-08	24013139	55103027	100167533	77	4350											
RPS6KA6	27330	broad.mit.edu	37	chrX	83320106	83320106	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgggtccatatgaagcataTgggaaagcaaatcctaaatt	10	6	0	1	rs149201069	byFrequency	TCGA-06-0875-01A-01W-0424-08	TCGA-06-0875-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	862cc896-a0dc-4f02-9940-8c9a5016027b	bfdef984-b955-4781-a600-ccefd97274ce	g.chrX:83320106T>C	uc004eej.1	-	21	2062	c.1985A>G	c.(1984-1986)CAT>CGT	p.H662R	RPS6KA6_uc011mqt.1_Missense_Mutation_p.H662R|RPS6KA6_uc011mqu.1_Missense_Mutation_p.H559R	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	662	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						ATGAAGCATATGGGAAAGCAA	0.299													C	83320106	C	C	83320106	3	2	65	1	0	0	0	0	1	0	0	0	13655	1464	51	4	260	4	RPS6KA6	23	83320106	Missense_Mutation	SNP	T	TCGA-06-0875-01A-01W-0424-08	28217079	83320106	71950454	78	4351											
CSMD2	114784	broad.mit.edu	37	chr1	34070881	34070881	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggatgagggagcgacataCcttcacacttgggcaggggg	18	8	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr1:34070881C>T	uc001bxn.1	-	43	6567	c.6538_splice	c.e43+1	p.V2180_splice	CSMD2_uc001bxm.1_Splice_Site_p.V2178_splice|CSMD2_uc001bxo.1_Splice_Site_p.V1051_splice	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GAGCGACATACCTTCACACTT	0.587													T	34070881	T	T	34070881	5	4	66	1	0	0	0	0	0	0	1	0	3945	521	18	3	4032	3	CSMD2	1	34070881	Splice_Site	SNP	C	TCGA-06-0876-01A-01W-0424-08		34070881	215179740	1	4352											
CLSPN	63967	broad.mit.edu	37	chr1	36228771	36228775	+	Frame_Shift_Del	DEL	TTTAC	-	-													ctttacttgccttgtgctttTttactttgttttttacagct							TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr1:36228771_36228775delTTTAC	uc001bzi.2	-	4	810_814	c.730_734delGTAAA	c.(730-735)GTAAAAfs	p.V244fs	CLSPN_uc009vux.2_Frame_Shift_Del_p.V244fs	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	244_245					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTTGTGCTTTTTTACTTTGTTTTTT	0.322													-	36228775	-	-	36228771	7	5	66	1	0	1	0	1	0	0	0	0	3560	1841	64	0	3373	0	CLSPN	1	36228771	Frame_Shift_Del	DEL	TTTAC	TCGA-06-0876-01A-01W-0424-08	2157890	36228771	213021850	2	4353											
LRRC8B	23507	broad.mit.edu	37	chr1	90050043	90050043	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tcagcctgaataatttgcatGagttagacctaagggaaaat	9	6	1	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr1:90050043G>A	uc001dni.2	+	7	2341	c.1834G>A	c.(1834-1836)GAG>AAG	p.E612K	LRRC8B_uc001dnh.2_Missense_Mutation_p.E612K|LRRC8B_uc001dnj.2_Missense_Mutation_p.E612K	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	612	LRR 7.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		TAATTTGCATGAGTTAGACCT	0.388													A	90050043	A	A	90050043	3	1	66	1	0	0	0	0	1	0	0	0	9022	1291	45	3	1836	3	LRRC8B	1	90050043	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	53821272	90050043	159200578	3	4354											
EPS8L3	79574	broad.mit.edu	37	chr1	110304367	110304367	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tggctctgctgctgggccttGacatgttgacgctgctgagg	15	10	1	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr1:110304367G>A	uc001dyr.1	-	2	150	c.5C>T	c.(4-6)TCA>TTA	p.S2L	EPS8L3_uc001dys.1_Missense_Mutation_p.S2L|EPS8L3_uc001dyq.1_Missense_Mutation_p.S2L|EPS8L3_uc009wfm.1_Intron|EPS8L3_uc009wfn.1_5'UTR|EPS8L3_uc009wfo.1_Missense_Mutation_p.S2L	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	2						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GCTGGGCCTTGACATGTTGAC	0.612													A	110304367	A	A	110304367	3	1	66	1	0	0	0	0	1	0	0	0	5197	1294	45	3	1851	3	EPS8L3	1	110304367	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	20254324	110304367	138946254	4	4355											
VTCN1	79679	broad.mit.edu	37	chr1	117699295	117699295	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagttgcacgtttttcagccGcaaagaggcattgccaacta	10	10	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr1:117699295G>A	uc001ehb.2	-	3	418	c.346C>T	c.(346-348)CGG>TGG	p.R116W	VTCN1_uc001ehc.2_Missense_Mutation_p.R21W|VTCN1_uc009whf.1_Intron	NM_024626	NP_078902	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation	116	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane					0	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		TTTTTCAGCCGCAAAGAGGCA	0.458													A	117699295	A	A	117699295	3	1	66	1	0	0	0	0	1	0	0	0	17231	1086	38	1	514	1	VTCN1	1	117699295	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	7394928	117699295	131551326	5	4356											
DPT	1805	broad.mit.edu	37	chr1	168670256	168670256	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaggggctgtctttctcaccTttccactgcagagaaagtgg	11	10	2	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr1:168670256T>A	uc001gfp.2	-	3	554	c.538A>T	c.(538-540)AGG>TGG	p.R180W		NM_001937	NP_001928	Q07507	DERM_HUMAN	dermatopontin precursor	180	2 X 53-55 AA tandem repeats.|3 X 6 AA repeats of D-R-[EQ]-W-[NQK]- [FY].				cell adhesion	extracellular space|proteinaceous extracellular matrix				ovary(1)	1	all_hematologic(923;0.208)					CTTTCTCACCTTTCCACTGCA	0.408													A	168670256	A	A	168670256	3	1	66	1	0	0	0	0	1	0	0	0	4739	1623	56	5	75	5	DPT	1	168670256	Missense_Mutation	SNP	T	TCGA-06-0876-01A-01W-0424-08	50970961	168670256	80580365	6	4357											
HHAT	55733	broad.mit.edu	37	chr1	210637955	210637955	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggactcactccacccgccctCccccgctgcgtgagcaccat	8	21	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr1:210637955C>T	uc009xcx.2	+	8	1129	c.963C>T	c.(961-963)CTC>CTT	p.L321L	HHAT_uc010psq.1_Silent_p.L184L|HHAT_uc001hhz.3_Silent_p.L321L|HHAT_uc010psr.1_Silent_p.L322L|HHAT_uc010pss.1_Silent_p.L276L|HHAT_uc009xcy.2_Silent_p.L256L|HHAT_uc010pst.1_Silent_p.L258L|HHAT_uc010psu.1_Silent_p.L256L|HHAT_uc001hia.3_Silent_p.L11L	NM_001122834	NP_001116306	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	321					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		CACCCGCCCTCCCCCGCTGCG	0.592													T	210637955	T	T	210637955	2	4	66	1	0	0	0	0	0	0	0	1	7089	842	30	3		3	HHAT	1	210637955	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	41967699	210637955	38612666	7	4358											
CENPF	1063	broad.mit.edu	37	chr1	214819979	214819979	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggacaaaccaagagcatgcaGctcttgaggcagagaattcc	11	10	1	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr1:214819979G>A	uc001hkm.2	+	13	7240	c.7066G>A	c.(7066-7068)GCT>ACT	p.A2356T		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2452	2-2.|Potential.|2 X 177 AA tandem repeats.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGAGCATGCAGCTCTTGAGGC	0.438													A	214819979	A	A	214819979	3	1	66	1	0	0	0	0	1	0	0	0	3231	971	34	3	7112	3	CENPF	1	214819979	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	4182024	214819979	34430642	8	4359											
TTC13	79573	broad.mit.edu	37	chr1	231059600	231059600	+	Frame_Shift_Del	DEL	T	-	-													ttcgtacctgattaaattaaTgtggttgttaaaacctctgc							TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr1:231059600delT	uc001huf.3	-	15	1832	c.1801delA	c.(1801-1803)ATTfs	p.I601fs	TTC13_uc009xfi.2_Frame_Shift_Del_p.I548fs|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Frame_Shift_Del_p.I548fs|TTC13_uc009xfk.1_Frame_Shift_Del_p.I491fs	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	601							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		ATTAAATTAATGTGGTTGTTA	0.438													-	231059600	-	-	231059600	7	5	66	1	0	1	0	1	0	0	0	0	16677	1464	51	0	817	0	TTC13	1	231059600	Frame_Shift_Del	DEL	T	TCGA-06-0876-01A-01W-0424-08	16239621	231059600	18191021	9	4360											
C2orf65	130951	broad.mit.edu	37	chr2	74787316	74787316	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcccagtgtgggtggagccGcccctgaggcttggcataga	15	12	0	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr2:74787316G>A	uc002smy.2	-	9	1501	c.1384C>T	c.(1384-1386)CGG>TGG	p.R462W	C2orf65_uc010ysa.1_Missense_Mutation_p.R462W|C2orf65_uc010ffp.2_Missense_Mutation_p.R111W|C2orf65_uc002smx.2_Missense_Mutation_p.R218W	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	462					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						GGGTGGAGCCGCCCCTGAGGC	0.473													A	74787316	A	A	74787316	3	1	66	1	0	0	0	0	1	0	0	0	2184	1086	38	1	220	1	C2orf65	2	74787316	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08		74787316	168412057	10	4361											
AMMECR1L	83607	broad.mit.edu	37	chr2	128631554	128631554	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggccggggaagagggctcagCgctcccgatgcgggattcat	17	11	2	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr2:128631554C>A	uc002tpl.2	-	3	506	c.255G>T	c.(253-255)GCG>GCT	p.A85A	AMMECR1L_uc002tpm.2_Silent_p.A85A	NM_031445	NP_113633	Q6DCA0	AMERL_HUMAN	AMME chromosomal region gene 1-like	85										central_nervous_system(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.07)		GAGGGCTCAGCGCTCCCGATG	0.547													A	128631554	A	A	128631554	2	1	66	1	0	0	0	0	0	0	0	1	579	755	27	5		5	AMMECR1L	2	128631554	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	53844238	128631554	114567819	11	4362											
FRAS1	80144	broad.mit.edu	37	chr4	79385647	79385647	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgtcgatgattcgctgccCgtcgtacagaacttaggaat	10	11	0	2	rs150936204	by1000genomes	TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr4:79385647C>T	uc003hlb.2	+	49	7379	c.6939C>T	c.(6937-6939)CCC>CCT	p.P2313P		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2312	CSPG 11.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ATTCGCTGCCCGTCGTACAGA	0.537													T	79385647	T	T	79385647	2	4	66	1	0	0	0	0	0	0	0	1	6042	639	23	2		2	FRAS1	4	79385647	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08		79385647	111768629	12	4363											
POU4F2	5458	broad.mit.edu	37	chr4	147561389	147561389	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccacgccggctcacgcgcCgcacatggccaccatgaacc	10	19	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr4:147561389C>T	uc003ikv.2	+	2	907	c.659C>T	c.(658-660)CCG>CTG	p.P220L		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	220					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					GCTCACGCGCCGCACATGGCC	0.726													T	147561389	T	T	147561389	3	4	66	1	0	0	0	0	1	0	0	0	12279	652	23	2	665	2	POU4F2	4	147561389	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	68175742	147561389	43592887	13	4364											
NR3C2	4306	broad.mit.edu	37	chr4	149357273	149357273	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtgcagggctgtgcgacCtggagcctcgattttcaaca	12	11	1	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr4:149357273C>T	uc003ilj.3	-	2	1074	c.740G>A	c.(739-741)AGG>AAG	p.R247K	NR3C2_uc003ilk.3_Missense_Mutation_p.R247K|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	247	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GCTGTGCGACCTGGAGCCTCG	0.532													T	149357273	T	T	149357273	3	4	66	1	0	0	0	0	1	0	0	0	10631	681	24	3	2246	3	NR3C2	4	149357273	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	1795884	149357273	41797003	14	4365											
FHDC1	85462	broad.mit.edu	37	chr4	153881733	153881733	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttaggtaaagaagttaaaagCgtttagtggcgacgtgtcga	13	4	0	1	rs149221149		TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr4:153881733C>T	uc003inf.2	+	4	755	c.680C>T	c.(679-681)GCG>GTG	p.A227V		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	227	FH2.				actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					AAGTTAAAAGCGTTTAGTGGC	0.363													T	153881733	T	T	153881733	3	4	66	1	0	0	0	0	1	0	0	0	5876	768	27	1	694	1	FHDC1	4	153881733	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	4524460	153881733	37272543	15	4366											
PLEKHG4B	153478	broad.mit.edu	37	chr5	143328	143328	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcccaagcaggtgctggaCgtcagtcaggagctgctgca	15	11	2	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr5:143328C>T	uc003jak.2	+	2	626	c.576C>T	c.(574-576)GAC>GAT	p.D192D		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	192					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGGTGCTGGACGTCAGTCAGG	0.662													T	143328	T	T	143328	2	4	66	1	0	0	0	0	0	0	0	1	12072	535	19	1		1	PLEKHG4B	5	143328	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08		143328	180771932	16	4367											
FTMT	94033	broad.mit.edu	37	chr5	121187738	121187738	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccggtgcgctgctgcttcgCgctcccgctgcgttgggccc	14	18	0	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr5:121187738C>T	uc003kss.2	+	1	89	c.80C>T	c.(79-81)GCG>GTG	p.A27V		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	27					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		TGCTGCTTCGCGCTCCCGCTG	0.741													T	121187738	T	T	121187738	3	4	66	1	0	0	0	0	1	0	0	0	6085	768	27	1	82	1	FTMT	5	121187738	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	121044410	121187738	59727522	17	4368											
PCDHA2	56146	broad.mit.edu	37	chr5	140175903	140175903	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggccgacgtgaacgacaacGcgccggcgttcgcacagcct	13	15	0	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr5:140175903G>A	uc003lhd.2	+	1	1460	c.1354G>A	c.(1354-1356)GCG>ACG	p.A452T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.A452T|PCDHA2_uc011czy.1_Missense_Mutation_p.A452T	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	452	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACGACAACGCGCCGGCGTT	0.647													A	140175903	A	A	140175903	3	1	66	1	0	0	0	0	1	0	0	0	11524	1087	38	1	1356	1	PCDHA2	5	140175903	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	18988165	140175903	40739357	18	4369											
ADRA1B	147	broad.mit.edu	37	chr5	159344026	159344026	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgagcaactccacactgccCcagctggacatcaccagggc	9	17	1	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr5:159344026C>T	uc003lxt.1	+	1	287	c.114C>T	c.(112-114)CCC>CCT	p.P38P		NM_000679	NP_000670	P35368	ADA1B_HUMAN	alpha-1B-adrenergic receptor	38	Extracellular (By similarity).				cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			lung(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	CCACACTGCCCCAGCTGGACA	0.587													T	159344026	T	T	159344026	2	4	66	1	0	0	0	0	0	0	0	1	335	610	22	3		3	ADRA1B	5	159344026	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	19168123	159344026	21571234	19	4370											
RGS14	10636	broad.mit.edu	37	chr5	176795734	176795734	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcagagccaccggaagagccTtgggagcacggagggtgaaa	16	9	1	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr5:176795734T>C	uc003mgf.2	+	9	1048	c.866T>C	c.(865-867)CTT>CCT	p.L289P	RGS14_uc003mgg.1_Missense_Mutation_p.L136P|RGS14_uc003mgh.2_Missense_Mutation_p.L136P|RGS14_uc003mgi.2_Missense_Mutation_p.L59P|RGS14_uc003mgj.2_5'Flank	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	289					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGAAGAGCCTTGGGAGCACG	0.582											OREG0017086	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	176795734	C	C	176795734	3	2	66	1	0	0	0	0	1	0	0	0	13297	1609	56	4	900	4	RGS14	5	176795734	Missense_Mutation	SNP	T	TCGA-06-0876-01A-01W-0424-08	17451708	176795734	4119526	20	4371											
ZKSCAN4	387032	broad.mit.edu	37	chr6	28213024	28213024	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtggattttctgatgttcaAtaagacttctattccgtgtg	9	6	3	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr6:28213024A>G	uc003nks.1	-	5	1752	c.1508T>C	c.(1507-1509)ATT>ACT	p.I503T	ZKSCAN4_uc011dlb.1_Missense_Mutation_p.I348T	NM_019110	NP_061983	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	503	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CTGATGTTCAATAAGACTTCT	0.428													G	28213024	G	G	28213024	3	3	66	1	0	0	0	0	1	0	0	0	17686	101	4	4	133	4	ZKSCAN4	6	28213024	Missense_Mutation	SNP	A	TCGA-06-0876-01A-01W-0424-08		28213024	142902043	21	4372											
SYNE1	23345	broad.mit.edu	37	chr6	152461140	152461140	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcagtgctgagttccagaCgctggagctgttccaactcc	11	12	1	2	rs143049227		TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr6:152461140C>T	uc010kiw.2	-	140	26005	c.25403G>A	c.(25402-25404)CGT>CAT	p.R8468H	SYNE1_uc010kiv.2_Missense_Mutation_p.R2992H|SYNE1_uc003qos.3_Missense_Mutation_p.R2992H|SYNE1_uc003qot.3_Missense_Mutation_p.R8420H|SYNE1_uc003qou.3_Missense_Mutation_p.R8468H|SYNE1_uc003qop.3_Missense_Mutation_p.R653H|SYNE1_uc011eez.1_Missense_Mutation_p.R670H|SYNE1_uc003qoq.3_Missense_Mutation_p.R670H|SYNE1_uc003qor.3_Missense_Mutation_p.R1391H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8468	Cytoplasmic (Potential).|Spectrin 31.		R -> H (in a colorectal cancer sample; somatic mutation).		cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.R8468H(1)		central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAGTTCCAGACGCTGGAGCTG	0.557										HNSCC(10;0.0054)			T	152461140	T	T	152461140	3	4	66	1	0	0	0	0	1	0	0	0	15442	536	19	1	1018	1	SYNE1	6	152461140	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	124248116	152461140	18653927	22	4373											
AHR	196	broad.mit.edu	37	chr7	17367444	17367444	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtcttttatgcttcttctaCtatacaagattatctagggt	7	7	4	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:17367444C>A	uc011jxz.1	+	4	1035	c.422C>A	c.(421-423)ACT>AAT	p.T141N	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	141	PAS 1.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					GCTTCTTCTACTATACAAGAT	0.264													A	17367444	A	A	17367444	3	1	66	1	0	0	0	0	1	0	0	0	416	565	20	5	436	5	AHR	7	17367444	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08		17367444	141771219	23	4374											
RAPGEF5	9771	broad.mit.edu	37	chr7	22165268	22165268	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agggttcggacagtgtctgcGatcatatgctgtaaagtaga	13	6	2	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:22165268G>A	uc003svg.2	-	25	2344	c.2031C>T	c.(2029-2031)ATC>ATT	p.I677I		NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	527	Ras-GEF.				nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						CAGTGTCTGCGATCATATGCT	0.463													A	22165268	A	A	22165268	2	1	66	1	0	0	0	0	0	0	0	1	13047	1048	37	2		2	RAPGEF5	7	22165268	Silent	SNP	G	TCGA-06-0876-01A-01W-0424-08	4797824	22165268	136973395	24	4375											
EGFR	1956	broad.mit.edu	37	chr7	55211080	55211080	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggaaaacctgcagatcatcaGaggaaatatgtactacgaaa	9	7	2	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:55211080G>A	uc003tqk.2	+	3	569	c.323G>A	c.(322-324)AGA>AAA	p.R108K	EGFR_uc003tqh.2_Missense_Mutation_p.R108K|EGFR_uc003tqi.2_Missense_Mutation_p.R108K|EGFR_uc003tqj.2_Missense_Mutation_p.R108K|EGFR_uc010kzg.1_Missense_Mutation_p.R108K|EGFR_uc011kco.1_Missense_Mutation_p.R55K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	108	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R108K(7)|p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGATCATCAGAGGAAATATG	0.423		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55211080	A	A	55211080	3	1	66	1	0	0	0	0	1	0	0	0	4967	942	33	3	333	3	EGFR	7	55211080	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	33045812	55211080	103927583	25	4376											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:55221822C>A	uc003tqk.2	+	7	1112	c.866C>A	c.(865-867)GCC>GAC	p.A289D	EGFR_uc003tqh.2_Missense_Mutation_p.A289D|EGFR_uc003tqi.2_Missense_Mutation_p.A289D|EGFR_uc003tqj.2_Missense_Mutation_p.A289D|EGFR_uc010kzg.1_Missense_Mutation_p.A244D|EGFR_uc011kco.1_Missense_Mutation_p.A236D|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55221822	A	A	55221822	3	1	66	1	0	0	0	0	1	0	0	0	4967	739	26	5	892	5	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	10742	55221822	103916841	26	4377											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	66	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	11221	55233043	103905620	27	4378											
ZKSCAN1	7586	broad.mit.edu	37	chr7	99621816	99621816	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacctgagatgctcgcaaggGggatggtgcctctggatcca	15	10	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:99621816G>A	uc003usk.1	+	3	685	c.466G>A	c.(466-468)GGG>AGG	p.G156R	ZKSCAN1_uc003usj.2_Missense_Mutation_p.G155R|ZKSCAN1_uc003usl.1_Missense_Mutation_p.G120R|ZKSCAN1_uc003usm.1_Intron	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	156					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GCTCGCAAGGGGGATGGTGCC	0.507													A	99621816	A	A	99621816	3	1	66	1	0	0	0	0	1	0	0	0	17683	1232	43	3	472	3	ZKSCAN1	7	99621816	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	44388773	99621816	59516847	28	4379											
DOCK4	9732	broad.mit.edu	37	chr7	111395650	111395650	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataatgacgttctctccaccCagagactctacaaaacacaa	4	13	2	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:111395650C>T	uc003vfx.2	-	41	4579	c.4310G>A	c.(4309-4311)TGG>TAG	p.W1437*	DOCK4_uc011kml.1_Nonsense_Mutation_p.W318*|DOCK4_uc011kmm.1_Nonsense_Mutation_p.W344*|DOCK4_uc003vfw.2_Nonsense_Mutation_p.W887*|DOCK4_uc003vfy.2_Nonsense_Mutation_p.W1482*	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1437	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TCTCTCCACCCAGAGACTCTA	0.453													T	111395650	T	T	111395650	4	4	66	1	0	0	0	0	0	1	0	0	4689	595	21	3	1638	3	DOCK4	7	111395650	Nonsense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	11773834	111395650	47743013	29	4380											
WNT2	7472	broad.mit.edu	37	chr7	116960624	116960624	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaggcaggagacttacttcGgagtaggaccctgccaaaaa	12	9	0	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:116960624G>A	uc003viz.2	-	2	607	c.307C>T	c.(307-309)CGA>TGA	p.R103*	WNT2_uc003vja.2_Missense_Mutation_p.P28L	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	103					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GACTTACTTCGGAGTAGGACC	0.537													A	116960624	A	A	116960624	4	1	66	1	0	0	0	0	0	1	0	0	17383	1124	39	2	791	2	WNT2	7	116960624	Nonsense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	5564974	116960624	42178039	30	4381											
TMEM209	84928	broad.mit.edu	37	chr7	129813714	129813714	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagaagtaaaagtttttccGtcgggatacttcggatgtgg	13	5	0	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:129813714G>A	uc003vpn.2	-	12	1533	c.1410C>T	c.(1408-1410)GAC>GAT	p.D470D	TMEM209_uc010lmc.1_Silent_p.D428D	NM_032842	NP_116231	Q96SK2	TM209_HUMAN	transmembrane protein 209	470						integral to membrane				ovary(2)|large_intestine(1)	3	Melanoma(18;0.0435)					AAGTTTTTCCGTCGGGATACT	0.363													A	129813714	A	A	129813714	2	1	66	1	0	0	0	0	0	0	0	1	16131	1136	40	1		1	TMEM209	7	129813714	Silent	SNP	G	TCGA-06-0876-01A-01W-0424-08	12853090	129813714	29324949	31	4382											
RAB19	401409	broad.mit.edu	37	chr7	140107592	140107592	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgagacacagcagaacaCgattggagtggactttaccg	11	10	0	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr7:140107592C>T	uc010lni.2	+	2	344	c.146C>T	c.(145-147)ACG>ATG	p.T49M	RAB19_uc011krc.1_Missense_Mutation_p.T49M	NM_001008749	NP_001008749	A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	49	Effector region (By similarity).				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0	Melanoma(164;0.0142)					CAGCAGAACACGATTGGAGTG	0.468													T	140107592	T	T	140107592	3	4	66	1	0	0	0	0	1	0	0	0	12904	536	19	1	148	1	RAB19	7	140107592	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	10293878	140107592	19031071	32	4383											
DLGAP2	9228	broad.mit.edu	37	chr8	1496906	1496906	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagccgccgctgtgttccgGgcacacgtgtggtctggcgc	15	15	1	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr8:1496906G>A	uc003wpl.2	+	2	144	c.47G>A	c.(46-48)GGG>GAG	p.G16E	DLGAP2_uc003wpm.2_Missense_Mutation_p.G16E	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	95					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CTGTGTTCCGGGCACACGTGT	0.721													A	1496906	A	A	1496906	3	1	66	1	0	0	0	0	1	0	0	0	4560	1232	43	3	49	3	DLGAP2	8	1496906	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08		1496906	144867116	33	4384											
ADAMDEC1	27299	broad.mit.edu	37	chr8	24254921	24254921	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtggtgtgaagagcactgaCgggaaacaaggcccaattcg	14	8	0	3	rs141288918		TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr8:24254921C>T	uc003xdz.2	+	6	799	c.579C>T	c.(577-579)GAC>GAT	p.D193D	ADAMDEC1_uc010lub.2_Silent_p.D114D|ADAMDEC1_uc011lab.1_Silent_p.D114D	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	193					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		AGAGCACTGACGGGAAACAAG	0.443													T	24254921	T	T	24254921	2	4	66	1	0	0	0	0	0	0	0	1	254	535	19	1		1	ADAMDEC1	8	24254921	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	22758015	24254921	122109101	34	4385											
SDCBP	6386	broad.mit.edu	37	chr8	59492353	59492353	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaatgtcattggattgaaGgtaaggaacagactttgtgc	12	5	1	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr8:59492353G>A	uc003xtn.2	+	7	900	c.750G>A	c.(748-750)AAG>AAA	p.K250K	SDCBP_uc003xto.2_Silent_p.K249K|SDCBP_uc003xtr.2_Silent_p.K249K|SDCBP_uc003xtp.2_Silent_p.K244K|SDCBP_uc003xtq.2_Silent_p.K250K|SDCBP_uc003xts.2_Silent_p.K256K|SDCBP_uc011led.1_Silent_p.K191K	NM_005625	NP_005616	O00560	SDCB1_HUMAN	syntenin isoform 1	250	PDZ 2.				actin cytoskeleton organization|axon guidance|positive regulation of phosphorylation|protein targeting to membrane|substrate-dependent cell migration, cell extension|synaptic transmission	cytoskeleton|cytosol|endoplasmic reticulum membrane|focal adhesion|interleukin-5 receptor complex|melanosome|nucleus	cytoskeletal adaptor activity|frizzled binding|interleukin-5 receptor binding|protein heterodimerization activity|protein N-terminus binding|syndecan binding				0		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TTGGATTGAAGGTAAGGAACA	0.398													A	59492353	A	A	59492353	2	1	66	1	0	0	0	0	0	0	0	1	13955	1014	35	3		3	SDCBP	8	59492353	Silent	SNP	G	TCGA-06-0876-01A-01W-0424-08	35237432	59492353	86871669	35	4386											
DOCK8	81704	broad.mit.edu	37	chr9	396909	396909	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgtggtcacctcggaaattgCagcccttttagtaaaaccac	8	11	1	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr9:396909C>G	uc003zgf.2	+	25	3207	c.3095C>G	c.(3094-3096)GCA>GGA	p.A1032G	DOCK8_uc010mgu.2_Missense_Mutation_p.A334G|DOCK8_uc010mgv.2_Missense_Mutation_p.A932G|DOCK8_uc010mgw.1_Missense_Mutation_p.A334G|DOCK8_uc003zgk.2_Missense_Mutation_p.A490G	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1032					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TCGGAAATTGCAGCCCTTTTA	0.274													G	396909	G	G	396909	3	3	66	1	0	0	0	0	1	0	0	0	4693	710	25	5	3193	5	DOCK8	9	396909	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08		396909	140816522	36	4387											
DOCK8	81704	broad.mit.edu	37	chr9	399200	399200	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggctttcttcttgtatgacCttctctccctcatggatcgg	8	12	4	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr9:399200C>G	uc003zgf.2	+	26	3287	c.3175C>G	c.(3175-3177)CTT>GTT	p.L1059V	DOCK8_uc010mgu.2_Missense_Mutation_p.L361V|DOCK8_uc010mgv.2_Missense_Mutation_p.L959V|DOCK8_uc010mgw.1_Missense_Mutation_p.L361V|DOCK8_uc003zgk.2_Missense_Mutation_p.L517V	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1059					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CTTGTATGACCTTCTCTCCCT	0.493													G	399200	G	G	399200	3	3	66	1	0	0	0	0	1	0	0	0	4693	681	24	5	3277	5	DOCK8	9	399200	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	2291	399200	140814231	37	4388											
DOCK8	81704	broad.mit.edu	37	chr9	439373	439373	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcctcctggagcaggccgcGgagctcttcagcacggtcag	15	14	3	0	rs144172375		TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr9:439373G>A	uc003zgf.2	+	40	5320	c.5208G>A	c.(5206-5208)GCG>GCA	p.A1736A	DOCK8_uc010mgu.2_Silent_p.A1038A|DOCK8_uc010mgv.2_Silent_p.A1636A|DOCK8_uc003zgk.2_Silent_p.A1194A	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1736	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AGCAGGCCGCGGAGCTCTTCA	0.647													A	439373	A	A	439373	2	1	66	1	0	0	0	0	0	0	0	1	4693	1103	39	2		2	DOCK8	9	439373	Silent	SNP	G	TCGA-06-0876-01A-01W-0424-08	40173	439373	140774058	38	4389											
OR2K2	26248	broad.mit.edu	37	chr9	114090506	114090506	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggcagatgtgtaacaaatatCcatgaaagagagatttccaa	9	6	0	4			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr9:114090506C>T	uc011lwp.1	-	1	208	c.208G>A	c.(208-210)GAT>AAT	p.D70N		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	99	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TAACAAATATCCATGAAAGAG	0.418													T	114090506	T	T	114090506	3	4	66	1	0	0	0	0	1	0	0	0	11005	855	30	3	745	3	OR2K2	9	114090506	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	113651133	114090506	27122925	39	4390											
COL27A1	85301	broad.mit.edu	37	chr9	117020836	117020836	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccagggtcctccaggatctCgaggcccaccaggcatgagg	13	15	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr9:117020836C>T	uc011lxl.1	+	28	3157	c.3157C>T	c.(3157-3159)CGA>TGA	p.R1053*	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1053	Pro-rich.|Collagen-like 7.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						TCCAGGATCTCGAGGCCCACC	0.622													T	117020836	T	T	117020836	4	4	66	1	0	0	0	0	0	1	0	0	3685	876	31	2	3267	2	COL27A1	9	117020836	Nonsense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	2930330	117020836	24192595	40	4391											
C9orf171	389799	broad.mit.edu	37	chr9	135374759	135374759	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtctctccctgccctcagCcatcggacgctggaacgtgt	12	15	2	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr9:135374759C>T	uc004cbn.2	+	4	452	c.404C>T	c.(403-405)GCC>GTC	p.A135V	C9orf171_uc004cbo.2_Missense_Mutation_p.A99V	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	135										ovary(4)|large_intestine(1)	5						CTGCCCTCAGCCATCGGACGC	0.647													T	135374759	T	T	135374759	3	4	66	1	0	0	0	0	1	0	0	0	2470	753	26	3	418	3	C9orf171	9	135374759	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	18353923	135374759	5838672	41	4392											
ANKRD30A	91074	broad.mit.edu	37	chr10	37508365	37508365	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaatgttgatgtgagtagtaCgatatataacaatgaggtgc	12	3	0	3	rs116869285	by1000genomes	TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr10:37508365C>T	uc001iza.1	+	34	3656	c.3557C>T	c.(3556-3558)ACG>ATG	p.T1186M		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1242						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GTGAGTAGTACGATATATAAC	0.363													T	37508365	T	T	37508365	3	4	66	1	0	0	0	0	1	0	0	0	658	536	19	1	3691	1	ANKRD30A	10	37508365	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08		37508365	98026382	42	4393											
CHAT	1103	broad.mit.edu	37	chr10	50873009	50873009	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcattgacatgagagacctcTgcagtctgctgccgcctact	9	13	3	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr10:50873009T>C	uc001jhz.2	+	15	2317	c.2164T>C	c.(2164-2166)TGC>CGC	p.C722R	CHAT_uc001jhv.1_Missense_Mutation_p.C604R|CHAT_uc001jhx.1_Missense_Mutation_p.C604R|CHAT_uc001jhy.1_Missense_Mutation_p.C604R|CHAT_uc001jia.2_Missense_Mutation_p.C604R|CHAT_uc010qgs.1_Intron	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	722					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GAGAGACCTCTGCAGTCTGCT	0.502													C	50873009	C	C	50873009	3	2	66	1	0	0	0	0	1	0	0	0	3313	1580	55	4	2266	4	CHAT	10	50873009	Missense_Mutation	SNP	T	TCGA-06-0876-01A-01W-0424-08	13364644	50873009	84661738	43	4394											
DLG5	9231	broad.mit.edu	37	chr10	79577582	79577582	+	Frame_Shift_Del	DEL	A	-	-													tggacccatgggtggctctcAtctcggagtagtcgctgcag							TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr10:79577582delA	uc001jzk.2	-	18	3807	c.3737delT	c.(3736-3738)ATGfs	p.M1246fs	DLG5_uc001jzi.2_Frame_Shift_Del_p.M1fs|DLG5_uc001jzj.2_Frame_Shift_Del_p.M661fs|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Frame_Shift_Del_p.M850fs	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1246					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GGTGGCTCTCATCTCGGAGTA	0.597													-	79577582	-	-	79577582	7	5	66	1	0	1	0	1	0	0	0	0	4558	217	8	0	2082	0	DLG5	10	79577582	Frame_Shift_Del	DEL	A	TCGA-06-0876-01A-01W-0424-08	28704573	79577582	55957165	44	4395											
PTEN	5728	broad.mit.edu	37	chr10	89653838	89653838	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagaaagacttgaaggcgtaTacaggaacaatattgatgat	10	5	0	5			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr10:89653838T>C	uc001kfb.2	+	3	1167	c.136T>C	c.(136-138)TAC>CAC	p.Y46H		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	46	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(4)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G44fs*8(1)|p.Y46*(1)|p.G44fs*11(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGAAGGCGTATACAGGAACAA	0.294		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89653838	C	C	89653838	3	2	66	1	0	0	0	0	1	0	0	0	12738	1406	49	4	142	4	PTEN	10	89653838	Missense_Mutation	SNP	T	TCGA-06-0876-01A-01W-0424-08	10076256	89653838	45880909	45	4396											
OR4X2	119764	broad.mit.edu	37	chr11	48266856	48266856	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggagatctgctactcctcCgctacagcccccaaactcat	6	16	2	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr11:48266856C>T	uc001ngs.1	+	1	201	c.201C>T	c.(199-201)TCC>TCT	p.S67S		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTACTCCTCCGCTACAGCCC	0.502													T	48266856	T	T	48266856	2	4	66	1	0	0	0	0	0	0	0	1	11085	639	23	2		2	OR4X2	11	48266856	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08		48266856	86739660	46	4397											
CTSW	1521	broad.mit.edu	37	chr11	65647754	65647754	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	accggagttacctgagcccaGaaggtatcacagggcacata	11	11	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr11:65647754G>A	uc001ogc.1	+	2	211	c.169G>A	c.(169-171)GAA>AAA	p.E57K	CTSW_uc001ogb.1_Missense_Mutation_p.E57K	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	57					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)		CCTGAGCccagaaggtatcac	0.269													A	65647754	A	A	65647754	3	1	66	1	0	0	0	0	1	0	0	0	4042	943	33	3	175	3	CTSW	11	65647754	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	17380898	65647754	69358762	47	4398											
ATN1	1822	broad.mit.edu	37	chr12	7046515	7046516	+	Frame_Shift_Ins	INS	-	C	C													cgcccaccgtgggacctgggINScccctgccacctgcggggcc							TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr12:7046515_7046516insC	uc001qrw.1	+	5	2322_2323	c.2085_2086insC	c.(2083-2088)GGGCCCfs	p.G695fs	ATN1_uc001qrx.1_Frame_Shift_Ins_p.G695fs	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	695_696					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TGGGACCTGGGCCCCTGCCACC	0.723													C	7046516	C	C	7046515	7	5	66	1	0	1	1	0	0	0	0	0	1111	1190	42	0	2099	0	ATN1	12	7046515	Frame_Shift_Ins	INS	-	TCGA-06-0876-01A-01W-0424-08		7046515	126805380	48	4399											
OR6C70	390327	broad.mit.edu	37	chr12	55863703	55863703	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taggaatctgggaatgcaagCagttgtgaatgaaatttcca	11	5	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr12:55863703C>A	uc010spn.1	-	1	220	c.220G>T	c.(220-222)GCT>TCT	p.A74S		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGAATGCAAGCAGTTGTGAAT	0.398													A	55863703	A	A	55863703	3	1	66	1	0	0	0	0	1	0	0	0	11197	710	25	5	720	5	OR6C70	12	55863703	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	48817188	55863703	77988192	49	4400											
IFNG	3458	broad.mit.edu	37	chr12	68551725	68551725	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcttttcgaagtcatctcGtttctttttgttgctattga	7	8	3	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr12:68551725G>A	uc001stw.1	-	3	460	c.334C>T	c.(334-336)CGA>TGA	p.R112*		NM_000619	NP_000610	P01579	IFNG_HUMAN	interferon, gamma precursor	112					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	AAGTCATCTCGTTTCTTTTTG	0.358													A	68551725	A	A	68551725	4	1	66	1	0	0	0	0	0	1	0	0	7548	1153	40	1	174	1	IFNG	12	68551725	Nonsense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	12688022	68551725	65300170	50	4401											
PXN	5829	broad.mit.edu	37	chr12	120651689	120651689	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccacagcgtgttgagggctgAgatatagttctccaggatgg	14	8	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr12:120651689A>C	uc001txt.2	-	11	1596	c.1465T>G	c.(1465-1467)TCA>GCA	p.S489A	PXN_uc001txu.2_Missense_Mutation_p.S301A|PXN_uc001txv.2_Missense_Mutation_p.S370A|PXN_uc001txx.2_Missense_Mutation_p.S322A|PXN_uc001txy.2_Missense_Mutation_p.S455A|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	489	LIM zinc-binding 3.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTGAGGGCTGAGATATAGTTC	0.617													C	120651689	C	C	120651689	3	2	66	1	0	0	0	0	1	0	0	0	12852	304	11	5	318	5	PXN	12	120651689	Missense_Mutation	SNP	A	TCGA-06-0876-01A-01W-0424-08	52099964	120651689	13200206	51	4402											
N4BP2L2	10443	broad.mit.edu	37	chr13	33017656	33017656	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgacattctgattccatgttGatggcacagaatgggttcat	10	7	2	4			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr13:33017656G>A	uc010abe.1	-	7	1040	c.1018C>T	c.(1018-1020)CAA>TAA	p.Q340*	N4BP2L2_uc001uug.2_Nonsense_Mutation_p.Q223*|N4BP2L2_uc010abd.1_Nonsense_Mutation_p.Q253*|N4BP2L2_uc001uuh.2_Nonsense_Mutation_p.Q171*|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Nonsense_Mutation_p.Q325*	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		ATTCCATGTTGATGGCACAGA	0.353													A	33017656	A	A	33017656	4	1	66	1	0	0	0	0	0	1	0	0	10112	1299	45	3	1252	3	N4BP2L2	13	33017656	Nonsense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08		33017656	82152222	52	4403											
COL4A1	1282	broad.mit.edu	37	chr13	110817226	110817226	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccttgctggcctttcgggCctggcagtccctgaagccct	11	16	0	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr13:110817226C>T	uc001vqw.3	-	46	4255	c.4133G>A	c.(4132-4134)GGC>GAC	p.G1378D	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1378	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GCCTTTCGGGCCTGGCAGTCC	0.642													T	110817226	T	T	110817226	3	4	66	1	0	0	0	0	1	0	0	0	3689	739	26	3	904	3	COL4A1	13	110817226	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	77799570	110817226	4352652	53	4404											
ANKDD1A	348094	broad.mit.edu	37	chr15	65209682	65209682	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgtggacgaggaggatgCggtaggggccctcacagagg	19	8	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr15:65209682C>T	uc002aoa.2	+	3	265	c.236C>T	c.(235-237)GCG>GTG	p.A79V	ANKDD1A_uc002anx.1_Missense_Mutation_p.A79V|ANKDD1A_uc002any.2_5'UTR|ANKDD1A_uc002anz.2_Intron|ANKDD1A_uc002aob.2_Missense_Mutation_p.A49V	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	79					signal transduction					ovary(1)	1						GAGGAGGATGCGGTAGGGGCC	0.592													T	65209682	T	T	65209682	3	4	66	1	0	0	0	0	1	0	0	0	624	768	27	1	246	1	ANKDD1A	15	65209682	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08		65209682	37321710	54	4405											
MAN2A2	4122	broad.mit.edu	37	chr15	91454400	91454400	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttccggctcactgaattccaGgatgacactcgcttaagtca	8	12	2	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr15:91454400G>A	uc010bnz.2	+	13	1991	c.1876_splice	c.e13-1	p.D626_splice	MAN2A2_uc010boa.2_Splice_Site_p.D668_splice|MAN2A2_uc002bqc.2_Splice_Site_p.D626_splice|MAN2A2_uc010uql.1_Splice_Site_p.D288_splice|MAN2A2_uc010uqm.1_Splice_Site_p.D205_splice|MAN2A2_uc010uqn.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2						mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CTGAATTCCAGGATGACACTC	0.612													A	91454400	A	A	91454400	5	1	66	1	0	0	0	0	0	0	1	0	9215	1014	35	3	1921	3	MAN2A2	15	91454400	Splice_Site	SNP	G	TCGA-06-0876-01A-01W-0424-08	26244718	91454400	11076992	55	4406											
CLDN9	9080	broad.mit.edu	37	chr16	3063836	3063836	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggctgaggccctcaagcGggagctgggggcctccctct	17	13	2	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr16:3063836G>A	uc010uwo.1	+	1	1380	c.473G>A	c.(472-474)CGG>CAG	p.R158Q		NM_020982	NP_066192	O95484	CLD9_HUMAN	claudin 9	158	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GCCCTCAAGCGGGAGCTGGGG	0.701													A	3063836	A	A	3063836	3	1	66	1	0	0	0	0	1	0	0	0	3492	1116	39	2	475	2	CLDN9	16	3063836	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08		3063836	87290917	56	4407											
FAM86A	196483	broad.mit.edu	37	chr16	5135684	5135684	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtgctcttcgtagggaaaCagtttctgctcatgacgagg	12	8	3	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr16:5135684C>T	uc002cyo.2	-	8	991	c.942G>A	c.(940-942)CTG>CTA	p.L314L	ALG1_uc002cyj.2_3'UTR|ALG1_uc002cym.2_3'UTR|ALG1_uc002cyn.2_3'UTR|ALG1_uc010bue.2_3'UTR|ALG1_uc010uxy.1_3'UTR|FAM86A_uc002cyp.2_Silent_p.L280L	NM_201400	NP_958802	Q96G04	FA86A_HUMAN	hypothetical protein LOC196483 isoform 1	314											0						CGTAGGGAAACAGTTTCTGCT	0.527													T	5135684	T	T	5135684	2	4	66	1	0	0	0	0	0	0	0	1	5643	465	17	3		3	FAM86A	16	5135684	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	2071848	5135684	85219069	57	4408											
FA2H	79152	broad.mit.edu	37	chr16	74748141	74748141	+	Frame_Shift_Del	DEL	C	-	-													gagggtgtggaaacagtaatCccacaatttagtgctgatac							TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr16:74748141delC	uc002fde.1	-	7	1134	c.1066delG	c.(1066-1068)GATfs	p.D356fs	FA2H_uc002fdd.1_Frame_Shift_Del_p.D129fs|FA2H_uc010vmy.1_RNA	NM_024306	NP_077282	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	356				D -> G (in Ref. 1; BAB71632).	cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity				0						AAACAGTAATCCCACAATTTA	0.582													-	74748141	-	-	74748141	7	5	66	1	0	1	0	1	0	0	0	0	5352	855	30	0	56	0	FA2H	16	74748141	Frame_Shift_Del	DEL	C	TCGA-06-0876-01A-01W-0424-08	69612457	74748141	15606612	58	4409											
AIPL1	23746	broad.mit.edu	37	chr17	6338338	6338338	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccccactcactcgggatccGgtgatgaagtttgggagctc	13	12	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr17:6338338G>A	uc002gcp.2	-	1	182	c.87C>T	c.(85-87)ACC>ACT	p.T29T	AIPL1_uc002gcq.2_Silent_p.T29T|AIPL1_uc002gcr.2_Silent_p.T29T|AIPL1_uc010clk.2_Silent_p.T29T|AIPL1_uc010cll.2_Silent_p.T29T|AIPL1_uc002gcs.2_Silent_p.T29T	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	29					protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)		CTCGGGATCCGGTGATGAAGT	0.597													A	6338338	A	A	6338338	2	1	66	1	0	0	0	0	0	0	0	1	436	1103	39	2		2	AIPL1	17	6338338	Silent	SNP	G	TCGA-06-0876-01A-01W-0424-08		6338338	74856872	59	4410											
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	16	11	1	1	rs121912651		TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577539	A	A	7577539	3	1	66	1	0	0	0	0	1	0	0	0	16378	1115	39	2	548	2	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	1239201	7577539	73617671	60	4411											
KCNJ12	3768	broad.mit.edu	37	chr17	21319710	21319710	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacaagacctatgaggtgccCtctacgccccgctgcagtgc	10	16	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr17:21319710C>T	uc002gyv.1	+	3	1761	c.1056C>T	c.(1054-1056)CCC>CCT	p.P352P		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	352	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	ATGAGGTGCCCTCTACGCCCC	0.567										Prostate(3;0.18)			T	21319710	T	T	21319710	2	4	66	1	0	0	0	0	0	0	0	1	8046	668	24	3		3	KCNJ12	17	21319710	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	13742171	21319710	59875500	61	4412											
C18orf26	284254	broad.mit.edu	37	chr18	52265157	52265157	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ataatatgcttggtgaataaCaaaggatcggccaattcctc	8	8	0	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr18:52265157C>A	uc002lfq.1	+	3	460	c.414C>A	c.(412-414)AAC>AAA	p.N138K	C18orf26_uc002lfp.1_Missense_Mutation_p.N86K	NM_173629	NP_775900	Q8N1N2	CR026_HUMAN	hypothetical protein LOC284254	138						integral to membrane					0				Colorectal(16;0.0193)|READ - Rectum adenocarcinoma(59;0.178)		TGGTGAATAACAAAGGATCGG	0.453													A	52265157	A	A	52265157	3	1	66	1	0	0	0	0	1	0	0	0	1900	477	17	5	424	5	C18orf26	18	52265157	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08		52265157	25812091	62	4413											
SERPINB12	89777	broad.mit.edu	37	chr18	61223463	61223463	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagataggcaaagatgatcGtcataaaaacatatttttct	7	5	2	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr18:61223463G>A	uc010xen.1	+	1	71	c.71G>A	c.(70-72)CGT>CAT	p.R24H	SERPINB12_uc010xeo.1_Missense_Mutation_p.R24H	NM_080474	NP_536722	Q96P63	SPB12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	24					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity				0						AAAGATGATCGTCATAAAAAC	0.393													A	61223463	A	A	61223463	3	1	66	1	0	0	0	0	1	0	0	0	14099	1145	40	1	73	1	SERPINB12	18	61223463	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	8958306	61223463	16853785	63	4414											
ADAMTS10	81794	broad.mit.edu	37	chr19	8661023	8661023	+	Missense_Mutation	SNP	A	G	G													atgggttggtcttcatggtaAtgtgggcagccatgagcttg							TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr19:8661023A>G	uc002mkj.1	-	11	1545	c.1271T>C	c.(1270-1272)ATT>ACT	p.I424T	ADAMTS10_uc002mkk.1_Missense_Mutation_p.I56T	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	424	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						CTTCATGGTAATGTGGGCAGC	0.592													G	8661023	G	G	8661023	3	3	66	1	0	0	0	0	1	0	0	0	256	101	4	4	2104	4	ADAMTS10	19	8661023	Missense_Mutation	SNP	A	TCGA-06-0876-01A-01W-0424-08		8661023	50467960	64	4415	5	2									
ADAMTS10	81794	broad.mit.edu	37	chr19	8661031	8661031	+	Silent	SNP	A	G	G													gtcttcatggtaatgtgggcAgccatgagcttggctgggtc							TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr19:8661031A>G	uc002mkj.1	-	11	1537	c.1263T>C	c.(1261-1263)GCT>GCC	p.A421A	ADAMTS10_uc002mkk.1_Silent_p.A53A	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	421	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TAATGTGGGCAGCCATGAGCT	0.592													G	8661031	G	G	8661031	2	3	66	1	0	0	0	0	0	0	0	1	256	175	7	4		4	ADAMTS10	19	8661031	Silent	SNP	A	TCGA-06-0876-01A-01W-0424-08	8	8661031	50467952	65	4416	5	2									
KLF1	10661	broad.mit.edu	37	chr19	12996209	12996209	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acccgggtgcgcgcacgtgtGcgctgcctgcctcttgcgcg	15	16	1	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr19:12996209G>A	uc002mvo.2	-	2	898	c.835C>T	c.(835-837)CAC>TAC	p.H279Y		NM_006563	NP_006554	Q13351	KLF1_HUMAN	erythroid Kruppel-like factor	279	C2H2-type 1.				erythrocyte differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0		Hepatocellular(1079;0.137)		GBM - Glioblastoma multiforme(1328;0.00016)|Lung(535;0.171)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCACGTGTGCGCTGCCTGC	0.692													A	12996209	A	A	12996209	3	1	66	1	0	0	0	0	1	0	0	0	8337	1319	46	3	261	3	KLF1	19	12996209	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	4335178	12996209	46132774	66	4417											
ZNF208	7757	broad.mit.edu	37	chr19	22155610	22155610	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagggtttctctccagtatgAattaccttatgtttagtaag	8	6	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr19:22155610A>G	uc002nqp.2	-	5	2075	c.1926T>C	c.(1924-1926)ATT>ATC	p.I642I	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTCCAGTATGAATTACCTTAT	0.363													G	22155610	G	G	22155610	2	3	66	1	0	0	0	0	0	0	0	1	17763	242	9	4		4	ZNF208	19	22155610	Silent	SNP	A	TCGA-06-0876-01A-01W-0424-08	9159401	22155610	36973373	67	4418											
RAB4B	53916	broad.mit.edu	37	chr19	41289974	41289974	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggcctcccgctttgcccagGagaatggtgagggctgtgtc	15	11	0	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr19:41289974G>A	uc002opd.1	+	5	534	c.424G>A	c.(424-426)GAG>AAG	p.E142K	RAB4B_uc002opc.1_RNA|RAB4B_uc002ope.1_Intron|EGLN2_uc010ehd.2_5'UTR|RAB4B_uc002opf.1_Missense_Mutation_p.E168K	NM_016154	NP_057238	P61018	RAB4B_HUMAN	ras-related GTP-binding protein 4b	142					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	intracellular|plasma membrane	GTP binding|GTPase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CTTTGCCCAGGAGAATGGTGA	0.627													A	41289974	A	A	41289974	3	1	66	1	0	0	0	0	1	0	0	0	12947	1175	41	3	442	3	RAB4B	19	41289974	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	19134364	41289974	17839009	68	4419											
SIGLEC9	27180	broad.mit.edu	37	chr19	51629378	51629378	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgactgtcttccaaggagaCggcacaggtaggatggagct	14	8	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr19:51629378C>T	uc002pvu.2	+	3	808	c.741C>T	c.(739-741)GAC>GAT	p.D247D	SIGLEC9_uc010yct.1_Silent_p.D247D	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	247	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		TCCAAGGAGACGGCACAGGTA	0.597													T	51629378	T	T	51629378	2	4	66	1	0	0	0	0	0	0	0	1	14315	535	19	1		1	SIGLEC9	19	51629378	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	10339404	51629378	7499605	69	4420											
CD33	945	broad.mit.edu	37	chr19	51728757	51728757	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctccctgagcatcgtagaCgccaggaggagggataatgg	15	9	0	2	rs141721735		TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr19:51728757C>T	uc002pwa.2	+	2	361	c.321C>T	c.(319-321)GAC>GAT	p.D107D	CD33_uc010eos.1_Silent_p.D107D|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	107	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GCATCGTAGACGCCAGGAGGA	0.507													T	51728757	T	T	51728757	2	4	66	1	0	0	0	0	0	0	0	1	3005	535	19	1		1	CD33	19	51728757	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	99379	51728757	7400226	70	4421											
ZNF841	284371	broad.mit.edu	37	chr19	52568811	52568811	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcgaggcctgagcgataaCggaagaccttgccacattca	12	11	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr19:52568811C>T	uc002pyl.1	-	5	2528	c.1976G>A	c.(1975-1977)CGT>CAT	p.R659H	ZNF841_uc010ydh.1_Missense_Mutation_p.R775H|ZNF841_uc010epk.1_Missense_Mutation_p.R351H	NM_001136499	NP_001129971	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	659	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAGCGATAACGGAAGACCTT	0.438													T	52568811	T	T	52568811	3	4	66	1	0	0	0	0	1	0	0	0	18186	536	19	1	454	1	ZNF841	19	52568811	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	840054	52568811	6560172	71	4422											
LPIN3	64900	broad.mit.edu	37	chr20	39977494	39977494	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aggcgctgagagtgagctatCcctgccggaaaagctgaggc	15	10	0	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr20:39977494C>T	uc002xjx.2	+	4	615	c.524C>T	c.(523-525)TCC>TTC	p.S175F	LPIN3_uc010ggh.2_Missense_Mutation_p.S175F|LPIN3_uc010zwf.1_RNA	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	lipin 3	175					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.000739)				AGTGAGCTATCCCTGCCGGAA	0.398													T	39977494	T	T	39977494	3	4	66	1	0	0	0	0	1	0	0	0	8920	855	30	3	534	3	LPIN3	20	39977494	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08		39977494	23048026	72	4423											
SEMG1	6406	broad.mit.edu	37	chr20	43837052	43837052	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagaaagatgtatcccaaCgcagtatttatagccaaact	7	9	0	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr20:43837052C>T	uc002xni.2	+	2	1171	c.1114C>T	c.(1114-1116)CGC>TGC	p.R372C	SEMG1_uc002xnj.2_Missense_Mutation_p.R312C|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	372	58 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				TGTATCCCAACGCAGTATTTA	0.418													T	43837052	T	T	43837052	3	4	66	1	0	0	0	0	1	0	0	0	14044	536	19	1	1120	1	SEMG1	20	43837052	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	3859558	43837052	19188468	73	4424											
ARFGEF2	10564	broad.mit.edu	37	chr20	47605879	47605879	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttagagatggagcaaatggCtaaaacagccaaagctctga	10	8	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr20:47605879C>A	uc002xtx.3	+	19	2743	c.2591C>A	c.(2590-2592)GCT>GAT	p.A864D	ARFGEF2_uc010zyf.1_Missense_Mutation_p.A157D	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	864					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			GAGCAAATGGCTAAAACAGCC	0.468													A	47605879	A	A	47605879	3	1	66	1	0	0	0	0	1	0	0	0	853	797	28	5	2665	5	ARFGEF2	20	47605879	Missense_Mutation	SNP	C	TCGA-06-0876-01A-01W-0424-08	3768827	47605879	15419641	74	4425											
ZNFX1	57169	broad.mit.edu	37	chr20	47865786	47865786	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctggcagcagagccggagcaTggggcctatttgattgttct	14	9	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr20:47865786T>G	uc002xui.2	-	14	4022	c.3775A>C	c.(3775-3777)ATG>CTG	p.M1259L		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1259							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AGCCGGAGCATGGGGCCTATT	0.527													G	47865786	G	G	47865786	3	3	66	1	0	0	0	0	1	0	0	0	18202	1464	51	5	1985	5	ZNFX1	20	47865786	Missense_Mutation	SNP	T	TCGA-06-0876-01A-01W-0424-08	259907	47865786	15159734	75	4426											
MX2	4600	broad.mit.edu	37	chr21	42771150	42771150	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agatgtttaatcaggacatcGaaaagttagtagaaggagaa	11	3	1	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr21:42771150G>A	uc002yzf.1	+	10	1404	c.1300G>A	c.(1300-1302)GAA>AAA	p.E434K	MX2_uc002yzg.1_Missense_Mutation_p.E157K|MX2_uc010gop.1_Intron	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	434					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				TCAGGACATCGAAAAGTTAGT	0.373													A	42771150	A	A	42771150	3	1	66	1	0	0	0	0	1	0	0	0	9998	1059	37	2	1334	2	MX2	21	42771150	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08		42771150	5358745	76	4427											
KRTAP10-8	386681	broad.mit.edu	37	chr21	46032419	46032419	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgcaagcccgtgtgctgCgtgtccatctgctctggagc	13	13	2	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr21:46032419C>T	uc002zfo.1	+	1	424	c.402C>T	c.(400-402)TGC>TGT	p.C134C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198695	NP_941968	P60410	KR108_HUMAN	keratin associated protein 10-8	134	19 X 5 AA repeats of C-C-X(3).|8.					keratin filament				large_intestine(1)|breast(1)	2						CCGTGTGCTGCGTGTCCATCT	0.627													T	46032419	T	T	46032419	2	4	66	1	0	0	0	0	0	0	0	1	8515	776	27	1		1	KRTAP10-8	21	46032419	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	3261269	46032419	2097476	77	4428											
PI4KA	5297	broad.mit.edu	37	chr22	21174060	21174060	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aacaccttcaagctcttccaGgacacggagggaatgaggag	12	10	2	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chr22:21174060G>C	uc002zsz.3	-	6	715	c.484C>G	c.(484-486)CTG>GTG	p.L162V	PI4KA_uc010gsq.1_Missense_Mutation_p.L220V	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	162					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			AGCTCTTCCAGGACACGGAGG	0.522													C	21174060	C	C	21174060	3	2	66	1	0	0	0	0	1	0	0	0	11873	991	35	5	5850	5	PI4KA	22	21174060	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08		21174060	30130506	78	4429											
ARSF	416	broad.mit.edu	37	chrX	3021960	3021960	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaggaggaagtctccctcaGgacaggtgatgtcatataaa	11	8	4	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chrX:3021960G>A	uc004cre.1	+	9	1481	c.1260G>A	c.(1258-1260)CAG>CAA	p.Q420Q	ARSF_uc004crf.1_Silent_p.Q420Q	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	420						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTCTCCCTCAGGACAGGTGAT	0.448													A	3021960	A	A	3021960	2	1	66	1	0	0	0	0	0	0	0	1	991	991	35	3		3	ARSF	23	3021960	Silent	SNP	G	TCGA-06-0876-01A-01W-0424-08		3021960	152248600	79	4430											
BCOR	54880	broad.mit.edu	37	chrX	39930272	39930272	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggcctcctccagggtgacCgactttggctttttgtcctg	11	12	0	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chrX:39930272C>T	uc004den.3	-	6	3484	c.3192G>A	c.(3190-3192)TCG>TCA	p.S1064S	BCOR_uc004dep.3_Silent_p.S1064S|BCOR_uc004deo.3_Silent_p.S1046S|BCOR_uc004dem.3_Silent_p.S1064S	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1064					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CCAGGGTGACCGACTTTGGCT	0.517													T	39930272	T	T	39930272	2	4	66	1	0	0	0	0	0	0	0	1	1386	639	23	2		2	BCOR	23	39930272	Silent	SNP	C	TCGA-06-0876-01A-01W-0424-08	36908312	39930272	115340288	80	4431											
SLC38A5	92745	broad.mit.edu	37	chrX	48319395	48319395	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaaggtgaggtatccaaagGttgctgtgagcccatacatg	13	7	0	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chrX:48319395G>T	uc010nid.2	-	13	1107	c.929C>A	c.(928-930)ACC>AAC	p.T310N	SLC38A5_uc004djk.3_Missense_Mutation_p.T259N	NM_033518	NP_277053	Q8WUX1	S38A5_HUMAN	solute carrier family 38, member 5	310	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				ovary(3)	3						GTATCCAAAGGTTGCTGTGAG	0.522													T	48319395	T	T	48319395	3	4	66	1	0	0	0	0	1	0	0	0	14607	1261	44	5	509	5	SLC38A5	23	48319395	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	8389123	48319395	106951165	81	4432											
HUWE1	10075	broad.mit.edu	37	chrX	53573431	53573431	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggtataacccagatggcgGgctccattcagtagcagctt	12	10	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chrX:53573431G>A	uc004dsp.2	-	70	11283	c.10881C>T	c.(10879-10881)GCC>GCT	p.A3627A	HUWE1_uc004dsn.2_Silent_p.A2435A|HUWE1_uc004dsq.1_5'Flank	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3627					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CCAGATGGCGGGCTCCATTCA	0.403													A	53573431	A	A	53573431	2	1	66	1	0	0	0	0	0	0	0	1	7461	1219	43	3		3	HUWE1	23	53573431	Silent	SNP	G	TCGA-06-0876-01A-01W-0424-08	5254036	53573431	101697129	82	4433											
ARMCX2	9823	broad.mit.edu	37	chrX	100911799	100911799	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtgtgagccccaggggttGctttcttggcagctgatgtt	14	9	1	2			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chrX:100911799G>A	uc004eid.2	-	3	1131	c.776C>T	c.(775-777)GCA>GTA	p.A259V	ARMCX2_uc004eie.3_Missense_Mutation_p.A259V|ARMCX2_uc004eif.3_Missense_Mutation_p.A259V|ARMCX2_uc004eig.3_Missense_Mutation_p.A259V|ARMCX2_uc010nnt.2_Missense_Mutation_p.A259V	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	259	Ala-rich.					integral to membrane	binding			ovary(6)	6						CCCAGGGGTTGCTTTCTTGGC	0.597													A	100911799	A	A	100911799	3	1	66	1	0	0	0	0	1	0	0	0	960	1319	46	3	1126	3	ARMCX2	23	100911799	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	47338368	100911799	54358761	83	4434											
NRK	203447	broad.mit.edu	37	chrX	105153109	105153109	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggcacctaggcttctgcaGgtacagtcccaggtatccaa	11	12	1	0			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chrX:105153109G>A	uc004emd.2	+	13	1779	c.1476G>A	c.(1474-1476)CAG>CAA	p.Q492Q	NRK_uc010npc.1_Silent_p.Q160Q	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	492	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GGCTTCTGCAGGTACAGTCCC	0.537										HNSCC(51;0.14)			A	105153109	A	A	105153109	2	1	66	1	0	0	0	0	0	0	0	1	10655	991	35	3		3	NRK	23	105153109	Silent	SNP	G	TCGA-06-0876-01A-01W-0424-08	4241310	105153109	50117451	84	4435											
DCX	1641	broad.mit.edu	37	chrX	110644367	110644367	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgaggcttcaccccactgcGgatgatggtaaccagcttgg	12	13	1	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chrX:110644367G>A	uc004epd.2	-	3	971	c.799C>T	c.(799-801)CGC>TGC	p.R267C	DCX_uc011msv.1_Missense_Mutation_p.R267C|DCX_uc004epe.2_Missense_Mutation_p.R186C|DCX_uc004epf.2_Missense_Mutation_p.R186C|DCX_uc004epg.2_Missense_Mutation_p.R186C	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	267	Doublecortin 2.		R -> C (in SBHX).		axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						ACCCCACTGCGGATGATGGTA	0.537													A	110644367	A	A	110644367	3	1	66	1	0	0	0	0	1	0	0	0	4318	1116	39	2	561	2	DCX	23	110644367	Missense_Mutation	SNP	G	TCGA-06-0876-01A-01W-0424-08	5491258	110644367	44626193	85	4436											
ANKRD58	347454	broad.mit.edu	37	chrX	118893488	118893488	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaggagagtggcagcgtcGcggaccaaggcgaaggacac	17	10	0	1			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chrX:118893488G>A	uc010nql.2	+	1	913	c.858G>A	c.(856-858)TCG>TCA	p.S286S		NM_001105576	NP_001099046	A6NJG2	ANR58_HUMAN	ankyrin repeat domain 58	286											0						TGGCAGCGTCGCGGACCAAGG	0.642													A	118893488	A	A	118893488	2	1	66	1	0	0	0	0	0	0	0	1	684	1074	38	1		1	ANKRD58	23	118893488	Silent	SNP	G	TCGA-06-0876-01A-01W-0424-08	8249121	118893488	36377072	86	4437											
CNGA2	1260	broad.mit.edu	37	chrX	150912487	150912487	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaactggcagtggtggctgaTgatggtgtgactcagtatgc	15	6	1	3			TCGA-06-0876-01A-01W-0424-08	TCGA-06-0876-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2f27319-4e84-4b12-bce1-623ea20722be	48e076de-da4b-49a6-8054-5b4a0ed77637	g.chrX:150912487T>A	uc004fey.1	+	7	1736	c.1512T>A	c.(1510-1512)GAT>GAA	p.D504E		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	504	cAMP (By similarity).|Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGGTGGCTGATGATGGTGTGA	0.398													A	150912487	A	A	150912487	3	1	66	1	0	0	0	0	1	0	0	0	3597	1461	51	5	1534	5	CNGA2	23	150912487	Missense_Mutation	SNP	T	TCGA-06-0876-01A-01W-0424-08	32018999	150912487	4358073	87	4438											
NPHP4	261734	broad.mit.edu	37	chr1	5965822	5965822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcttccaggtgggagatacCggcctccaacgggaactcct	13	13	0	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr1:5965822C>T	uc001alq.1	-	14	1899	c.1633G>A	c.(1633-1635)GGT>AGT	p.G545S	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_RNA|NPHP4_uc009vlu.1_5'Flank	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	545					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGAGATACCGGCCTCCAAC	0.582													T	5965822	T	T	5965822	3	4	67	1	0	0	0	0	1	0	0	0	10581	652	23	2	2715	2	NPHP4	1	5965822	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08		5965822	243284799	1	4439											
PUM1	9698	broad.mit.edu	37	chr1	31479941	31479941	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcccaaaactttttacctggCaagagctgctgcaaattaaa	6	10	0	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr1:31479941C>G	uc001bsi.1	-	4	554	c.441G>C	c.(439-441)TTG>TTC	p.L147F	PUM1_uc001bsg.1_5'Flank|PUM1_uc001bsh.1_Missense_Mutation_p.L147F|PUM1_uc001bsj.1_Missense_Mutation_p.L147F|PUM1_uc010oga.1_Intron|PUM1_uc001bsk.1_Missense_Mutation_p.L183F|PUM1_uc010ogb.1_Intron	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	147					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TTTTACCTGGCAAGAGCTGCT	0.393													G	31479941	G	G	31479941	3	3	67	1	0	0	0	0	1	0	0	0	12825	709	25	5	3201	5	PUM1	1	31479941	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	25514119	31479941	217770680	2	4440											
POLR3C	10623	broad.mit.edu	37	chr1	145608488	145608488	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttcaacagaagctcctcaaCaatcagctctccagtgtcac	6	14	5	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr1:145608488C>T	uc001eoh.2	-	3	480	c.319G>A	c.(319-321)GTT>ATT	p.V107I	NBPF10_uc001emp.3_Intron|RNF115_uc001eoj.2_5'Flank|RNF115_uc001eok.2_5'Flank|RNF115_uc009wiy.2_5'Flank|POLR3C_uc001eog.2_Missense_Mutation_p.V120I|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Missense_Mutation_p.V107I	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	107					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			AGCTCCTCAACAATCAGCTCT	0.493													T	145608488	T	T	145608488	3	4	67	1	0	0	0	0	1	0	0	0	12230	478	17	3	1337	3	POLR3C	1	145608488	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	114128547	145608488	103642133	3	4441											
C1orf129	80133	broad.mit.edu	37	chr1	170961347	170961347	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggcatgttctcaggcgagCgtggcccctcacgtgctgaa	14	13	2	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr1:170961347C>T	uc001ghg.2	+	12	1201	c.1071C>T	c.(1069-1071)AGC>AGT	p.S357S	C1orf129_uc009wvy.2_Silent_p.S164S|C1orf129_uc010plz.1_Silent_p.S357S	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	357							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTCAGGCGAGCGTGGCCCCTC	0.493													T	170961347	T	T	170961347	2	4	67	1	0	0	0	0	0	0	0	1	1996	767	27	1		1	C1orf129	1	170961347	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	25352859	170961347	78289274	4	4442											
RYR2	6262	broad.mit.edu	37	chr1	237604756	237604756	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtctgtggacgtgaaatcCgtgagaatgggatctataca	12	7	2	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr1:237604756C>T	uc001hyl.1	+	13	1263	c.1143C>T	c.(1141-1143)TCC>TCT	p.S381S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	381	Cytoplasmic (By similarity).|MIR 5.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACGTGAAATCCGTGAGAATGG	0.348													T	237604756	T	T	237604756	2	4	67	1	0	0	0	0	0	0	0	1	13769	639	23	2		2	RYR2	1	237604756	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	66643409	237604756	11645865	5	4443											
PLD5	200150	broad.mit.edu	37	chr1	242383388	242383388	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagccggcccttgttgtaagCggtcatgttcatgtacgtca	11	11	3	0	rs140243407	byFrequency	TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr1:242383388C>T	uc001hzn.1	-	5	764	c.637G>A	c.(637-639)GCT>ACT	p.A213T	PLD5_uc001hzl.3_Missense_Mutation_p.A151T|PLD5_uc001hzm.3_Missense_Mutation_p.A3T|PLD5_uc001hzo.1_Missense_Mutation_p.A121T			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	213						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TTGTTGTAAGCGGTCATGTTC	0.577													T	242383388	T	T	242383388	3	4	67	1	0	0	0	0	1	0	0	0	12049	768	27	1	997	1	PLD5	1	242383388	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	4778632	242383388	6867233	6	4444											
OR2B11	127623	broad.mit.edu	37	chr1	247614785	247614785	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcagaatggcaattgcaccGtcaggaccacctgcacgaag	11	13	1	1	rs149375684	byFrequency	TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr1:247614785G>A	uc010pyx.1	-	1	500	c.500C>T	c.(499-501)ACG>ATG	p.T167M		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CAATTGCACCGTCAGGACCAC	0.592													A	247614785	A	A	247614785	3	1	67	1	0	0	0	0	1	0	0	0	10988	1145	40	1	456	1	OR2B11	1	247614785	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	5231397	247614785	1635836	7	4445											
CLIP4	79745	broad.mit.edu	37	chr2	29386734	29386734	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gagcttgaaaaaccccatggCaagaatgatggttcagttgg	12	7	1	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr2:29386734C>G	uc002rmv.2	+	13	1811	c.1572C>G	c.(1570-1572)GGC>GGG	p.G524G	CLIP4_uc002rmu.2_Silent_p.G524G|CLIP4_uc002rmw.2_RNA	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	524	CAP-Gly 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					AACCCCATGGCAAGAATGATG	0.388													G	29386734	G	G	29386734	2	3	67	1	0	0	0	0	0	0	0	1	3535	697	25	5		5	CLIP4	2	29386734	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08		29386734	213812639	8	4446											
ACTG2	72	broad.mit.edu	37	chr2	74128551	74128551	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcccctccattgtgggccGccctcgccaccaggtgcgtg	11	18	0	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr2:74128551G>A	uc002sjw.2	+	2	235	c.113G>A	c.(112-114)CGC>CAC	p.R38H	ACTG2_uc010fex.1_Missense_Mutation_p.R38H|ACTG2_uc010fey.2_Missense_Mutation_p.R38H|ACTG2_uc010yrn.1_Missense_Mutation_p.R38H	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	38					muscle contraction	cytoskeleton|cytosol	ATP binding				0						ATTGTGGGCCGCCCTCGCCAC	0.637													A	74128551	A	A	74128551	3	1	67	1	0	0	0	0	1	0	0	0	197	1087	38	1	115	1	ACTG2	2	74128551	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	44741817	74128551	169070822	9	4447											
CNTNAP5	129684	broad.mit.edu	37	chr2	125547685	125547685	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gctacctgtgtgattgcaccAattcaccttatgaagggccc	9	12	1	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr2:125547685A>T	uc002tno.2	+	18	3320	c.2956A>T	c.(2956-2958)AAT>TAT	p.N986Y	CNTNAP5_uc010flu.2_Missense_Mutation_p.N987Y	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	986	EGF-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGATTGCACCAATTCACCTTA	0.552													T	125547685	T	T	125547685	3	4	67	1	0	0	0	0	1	0	0	0	3650	130	5	5	3026	5	CNTNAP5	2	125547685	Missense_Mutation	SNP	A	TCGA-06-0877-01A-01W-0424-08	51419134	125547685	117651688	10	4448											
CDCA7	83879	broad.mit.edu	37	chr2	174231123	174231123	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcccctgccttcgaaaccGttatggtgaagaggtcaggg	14	10	1	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr2:174231123G>A	uc002uid.1	+	7	1042	c.911G>A	c.(910-912)CGT>CAT	p.R304H	CDCA7_uc002uic.1_Missense_Mutation_p.R383H|CDCA7_uc010zej.1_Missense_Mutation_p.R339H|CDCA7_uc010zek.1_Missense_Mutation_p.R262H	NM_145810	NP_665809	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7 isoform 2	304	Mediates transcriptional activity.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.116)			CTTCGAAACCGTTATGGTGAA	0.557													A	174231123	A	A	174231123	3	1	67	1	0	0	0	0	1	0	0	0	3090	1145	40	1	1178	1	CDCA7	2	174231123	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	48683438	174231123	68968250	11	4449											
IRS1	3667	broad.mit.edu	37	chr2	227661504	227661504	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cactctctggggatggcgtcTgatgggattgatgatctgct	14	8	3	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr2:227661504T>C	uc002voh.3	-	1	2003	c.1951A>G	c.(1951-1953)AGA>GGA	p.R651G		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	651					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GGATGGCGTCTGATGGGATTG	0.562											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	227661504	C	C	227661504	3	2	67	1	0	0	0	0	1	0	0	0	7840	1588	55	4	1781	4	IRS1	2	227661504	Missense_Mutation	SNP	T	TCGA-06-0877-01A-01W-0424-08	53430381	227661504	15537869	12	4450											
EOMES	8320	broad.mit.edu	37	chr3	27761789	27761789	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgggattgagtccgtttatGttgaagctcaagaaaggaaa	13	4	1	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr3:27761789G>A	uc003cdx.2	-	2	909	c.909C>T	c.(907-909)AAC>AAT	p.N303N	EOMES_uc003cdy.3_Silent_p.N303N|EOMES_uc010hfn.2_Silent_p.N303N|EOMES_uc011axc.1_Silent_p.N8N	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	303	T-box.				CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						GTCCGTTTATGTTGAAGCTCA	0.532													A	27761789	A	A	27761789	2	1	67	1	0	0	0	0	0	0	0	1	5147	1368	48	3		3	EOMES	3	27761789	Silent	SNP	G	TCGA-06-0877-01A-01W-0424-08		27761789	170260641	13	4451											
ZNF197	10168	broad.mit.edu	37	chr3	44685661	44685661	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atccataccattgaggaattCtcttggctacaaaacaccaa	5	11	1	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr3:44685661C>G	uc003cnm.2	+	6	3245	c.3039C>G	c.(3037-3039)TTC>TTG	p.F1013L	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	1013					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		TTGAGGAATTCTCTTGGCTAC	0.363													G	44685661	G	G	44685661	3	3	67	1	0	0	0	0	1	0	0	0	17756	912	32	5	3057	5	ZNF197	3	44685661	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	16923872	44685661	153336769	14	4452											
ITIH3	3699	broad.mit.edu	37	chr3	52840313	52840313	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctaatgtgtcaccagtggaCggggatccccacttcatcat	9	12	4	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr3:52840313C>T	uc003dfv.2	+	18	1983	c.1947C>T	c.(1945-1947)GAC>GAT	p.D649D	ITIH3_uc011bek.1_Intron	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	649					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CACCAGTGGACGGGGATCCCC	0.582													T	52840313	T	T	52840313	2	4	67	1	0	0	0	0	0	0	0	1	7905	535	19	1		1	ITIH3	3	52840313	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	8154652	52840313	145182117	15	4453											
EPHA3	2042	broad.mit.edu	37	chr3	89468496	89468496	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agcaagcattatgggacagtTtgaccaccccaatatcattc	7	11	1	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr3:89468496T>A	uc003dqy.2	+	11	2255	c.2030T>A	c.(2029-2031)TTT>TAT	p.F677Y	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	677	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATGGGACAGTTTGACCACCCC	0.413										TSP Lung(6;0.00050)			A	89468496	A	A	89468496	3	1	67	1	0	0	0	0	1	0	0	0	5168	1841	64	5	2098	5	EPHA3	3	89468496	Missense_Mutation	SNP	T	TCGA-06-0877-01A-01W-0424-08	36628183	89468496	108553934	16	4454											
ADCY5	111	broad.mit.edu	37	chr3	123166426	123166426	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgccctcagaggcgctgcGtggctgcggcagcagcaggc	17	13	1	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr3:123166426G>A	uc003egh.1	-	1	967	c.967C>T	c.(967-969)CGC>TGC	p.R323C		NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	323					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GAGGCGCTGCGTGGCTGCGGC	0.687													A	123166426	A	A	123166426	3	1	67	1	0	0	0	0	1	0	0	0	297	1145	40	1	2902	1	ADCY5	3	123166426	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	33697930	123166426	74856004	17	4455											
TRH	7200	broad.mit.edu	37	chr3	129694827	129694827	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcgcctcctcttcctccgGgaaaacatccagcggctgca	10	16	1	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr3:129694827G>A	uc003enc.2	+	2	729	c.168G>A	c.(166-168)CGG>CGA	p.R56R		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	56					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						TCTTCCTCCGGGAAAACATCC	0.672													A	129694827	A	A	129694827	2	1	67	1	0	0	0	0	0	0	0	1	16475	1219	43	3		3	TRH	3	129694827	Silent	SNP	G	TCGA-06-0877-01A-01W-0424-08	6528401	129694827	68327603	18	4456											
MBNL1	4154	broad.mit.edu	37	chr3	152018103	152018103	+	Frame_Shift_Del	DEL	A	-	-													gtaaatttgcacatccttcgAaaagctgccaagttgaaaat							TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr3:152018103delA	uc003ezm.2	+	1	910	c.121delA	c.(121-123)AAAfs	p.K41fs	MBNL1_uc003ezh.2_Frame_Shift_Del_p.K41fs|MBNL1_uc003ezi.2_Frame_Shift_Del_p.K41fs|MBNL1_uc003ezj.2_Intron|MBNL1_uc003ezl.2_Frame_Shift_Del_p.K41fs|MBNL1_uc003ezp.2_Frame_Shift_Del_p.K41fs|MBNL1_uc003ezn.2_Frame_Shift_Del_p.K41fs|MBNL1_uc003ezo.2_Frame_Shift_Del_p.K41fs|MBNL1_uc003ezg.1_RNA|MBNL1_uc003ezk.1_RNA	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	muscleblind-like 1 isoform c	41	C3H1-type 1.				embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			ACATCCTTCGAAAAGCTGCCA	0.403													-	152018103	-	-	152018103	7	5	67	1	0	1	0	1	0	0	0	0	9353	247	9	0	123	0	MBNL1	3	152018103	Frame_Shift_Del	DEL	A	TCGA-06-0877-01A-01W-0424-08	22323276	152018103	46004327	19	4457											
DGKG	1608	broad.mit.edu	37	chr3	186015248	186015248	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctcgtctgctttggtggcaTtatctgcattctgtatatta	8	9	3	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr3:186015248T>G	uc003fqa.2	-	5	872	c.335A>C	c.(334-336)AAT>ACT	p.N112T	DGKG_uc003fqb.2_Missense_Mutation_p.N112T|DGKG_uc003fqc.2_Missense_Mutation_p.N112T|DGKG_uc011brx.1_Missense_Mutation_p.N112T	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	112					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TTTGGTGGCATTATCTGCATT	0.458													G	186015248	G	G	186015248	3	3	67	1	0	0	0	0	1	0	0	0	4469	1493	52	5	2124	5	DGKG	3	186015248	Missense_Mutation	SNP	T	TCGA-06-0877-01A-01W-0424-08	33997145	186015248	12007182	20	4458											
TLR6	10333	broad.mit.edu	37	chr4	38829222	38829222	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tatgttcctggccctgcgccGagtctgggtccactggcaca	12	14	1	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr4:38829222G>A	uc003gtm.2	-	1	1939	c.1873C>T	c.(1873-1875)CGG>TGG	p.R625W	TLR6_uc010ifg.1_Missense_Mutation_p.R625W	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	625	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						GCCCTGCGCCGAGTCTGGGTC	0.512													A	38829222	A	A	38829222	3	1	67	1	0	0	0	0	1	0	0	0	15952	1057	37	2	521	2	TLR6	4	38829222	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08		38829222	152325054	21	4459											
UGT2B10	7365	broad.mit.edu	37	chr4	69696459	69696459	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gttgcagcccacaacctcacCtggttccagtaccactcttt	6	16	2	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr4:69696459C>G	uc003hee.2	+	6	1474	c.1449C>G	c.(1447-1449)ACC>ACG	p.T483T	UGT2B10_uc011cam.1_Silent_p.T399T	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	483					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						ACAACCTCACCTGGTTCCAGT	0.483													G	69696459	G	G	69696459	2	3	67	1	0	0	0	0	0	0	0	1	16953	668	24	5		5	UGT2B10	4	69696459	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	30867237	69696459	121457817	22	4460											
PROL1	58503	broad.mit.edu	37	chr4	71275346	71275346	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacaacctcgactctttccgGgttatccaaacctacatttc	5	14	1	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr4:71275346G>T	uc003hfi.2	+	3	475	c.301G>T	c.(301-303)GGT>TGT	p.G101C		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	101	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				ACTCTTTCCGGGTTATCCAAA	0.398													T	71275346	T	T	71275346	3	4	67	1	0	0	0	0	1	0	0	0	12554	1232	43	5	307	5	PROL1	4	71275346	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	1578887	71275346	119878930	23	4461											
AFM	173	broad.mit.edu	37	chr4	74365895	74365895	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagatttatttacctttcacGcagacatgtgtcaatctcag	6	9	3	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr4:74365895G>A	uc003hhb.2	+	12	1628	c.1597G>A	c.(1597-1599)GCA>ACA	p.A533T		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	533	Albumin 3.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TACCTTTCACGCAGACATGTG	0.393													A	74365895	A	A	74365895	3	1	67	1	0	0	0	0	1	0	0	0	361	1087	38	1	1643	1	AFM	4	74365895	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	3090549	74365895	116788381	24	4462											
ADAMTS16	170690	broad.mit.edu	37	chr5	5146486	5146486	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taagtctgtgcagactttacCgccagaggacttctgtttct	9	10	3	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr5:5146486C>T	uc003jdl.2	+	3	557	c.419C>T	c.(418-420)CCG>CTG	p.P140L	ADAMTS16_uc003jdk.1_Missense_Mutation_p.P140L|ADAMTS16_uc003jdj.1_Missense_Mutation_p.P140L	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	140					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CAGACTTTACCGCCAGAGGAC	0.522													T	5146486	T	T	5146486	3	4	67	1	0	0	0	0	1	0	0	0	261	652	23	2	429	2	ADAMTS16	5	5146486	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08		5146486	175768774	25	4463											
RICTOR	253260	broad.mit.edu	37	chr5	38972038	38972038	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agactggatcccagaatttcCaggtttacataaattaataa	6	7	0	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr5:38972038C>T	uc003jlp.2	-	11	937	c.913G>A	c.(913-915)GGA>AGA	p.G305R	RICTOR_uc003jlo.2_Missense_Mutation_p.G305R|RICTOR_uc010ivf.2_Missense_Mutation_p.G20R|RICTOR_uc003jlq.1_Missense_Mutation_p.G289R	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	305					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					CCAGAATTTCCAGGTTTACAT	0.299													T	38972038	T	T	38972038	3	4	67	1	0	0	0	0	1	0	0	0	13358	603	21	3	4325	3	RICTOR	5	38972038	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	33825552	38972038	141943222	26	4464											
PIK3R1	5295	broad.mit.edu	37	chr5	67589138	67589138	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attgtttttacaggaaagggGgaaataacaaattaatcaaa	8	3	1	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr5:67589138G>A	uc003jva.2	+	10	1686	c.1126G>A	c.(1126-1128)GGA>AGA	p.G376R	PIK3R1_uc003jvb.2_Missense_Mutation_p.G376R|PIK3R1_uc003jvc.2_Missense_Mutation_p.G76R|PIK3R1_uc003jvd.2_Missense_Mutation_p.G106R|PIK3R1_uc003jve.2_Missense_Mutation_p.G55R|PIK3R1_uc011crb.1_Missense_Mutation_p.G46R	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	376	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.G376R(3)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CAGGAAAGGGGGAAATAACAA	0.308			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			A	67589138	A	A	67589138	3	1	67	1	0	0	0	0	1	0	0	0	11918	1233	43	3	1290	3	PIK3R1	5	67589138	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	28617100	67589138	113326122	27	4465											
ATP10B	23120	broad.mit.edu	37	chr5	160047524	160047524	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaggtgccctggggcaggCgcacagtcacctgctcaggt	16	13	2	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr5:160047524C>T	uc003lym.1	-	15	3093	c.2246G>A	c.(2245-2247)CGC>CAC	p.R749H	ATP10B_uc010jit.1_Missense_Mutation_p.R66H|ATP10B_uc003lyn.2_Missense_Mutation_p.R307H	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	749	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGGGGCAGGCGCACAGTCAC	0.612													T	160047524	T	T	160047524	3	4	67	1	0	0	0	0	1	0	0	0	1117	768	27	1	2187	1	ATP10B	5	160047524	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	92458386	160047524	20867736	28	4466											
ALDH5A1	7915	broad.mit.edu	37	chr6	24502755	24502755	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttatttcttttgcaggagaGgagttcattacttcggaagt	11	5	2	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr6:24502755G>A	uc003neg.2	+	2	387	c.359G>A	c.(358-360)AGG>AAG	p.R120K	ALDH5A1_uc003nef.2_Missense_Mutation_p.R120K	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	120					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TTGCAGGAGAGGAGTTCATTA	0.343													A	24502755	A	A	24502755	3	1	67	1	0	0	0	0	1	0	0	0	502	1000	35	3	365	3	ALDH5A1	6	24502755	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08		24502755	146612312	29	4467											
C6orf138	442213	broad.mit.edu	37	chr6	47976593	47976593	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cttctggccaggatgctggtCttatgaaagtccctccagag	11	11	2	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr6:47976593C>A	uc011dwm.1	-	2	718	c.633G>T	c.(631-633)AAG>AAT	p.K211N	C6orf138_uc011dwn.1_5'UTR|C6orf138_uc003ozf.2_Missense_Mutation_p.K228N	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	228						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						GGATGCTGGTCTTATGAAAGT	0.522													A	47976593	A	A	47976593	3	1	67	1	0	0	0	0	1	0	0	0	2332	912	32	5	1864	5	C6orf138	6	47976593	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	23473838	47976593	123138474	30	4468											
RHAG	6005	broad.mit.edu	37	chr6	49574864	49574864	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttcactttttatgctgaccTgtcatcagacctccaacaac	5	13	3	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr6:49574864T>G	uc003ozk.3	-	8	1199	c.1137A>C	c.(1135-1137)ACA>ACC	p.T379T	RHAG_uc010jzl.2_Silent_p.T379T|RHAG_uc010jzm.2_Silent_p.R339R	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	379	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					TATGCTGACCTGTCATCAGAC	0.398													G	49574864	G	G	49574864	2	3	67	1	0	0	0	0	0	0	0	1	13315	1594	55	5		5	RHAG	6	49574864	Silent	SNP	T	TCGA-06-0877-01A-01W-0424-08	1598271	49574864	121540203	31	4469											
GSTA4	2941	broad.mit.edu	37	chr6	52850344	52850344	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accaacttcatcccgtcaatTtcaaccatgggcacttgttg	6	13	3	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr6:52850344T>G	uc003pbc.2	-	3	241	c.177A>C	c.(175-177)GAA>GAC	p.E59D	GSTA4_uc003pbd.2_5'UTR|GSTA4_uc003pbe.2_Intron|GSTA4_uc003pbf.2_Missense_Mutation_p.E59D	NM_001512	NP_001503	O15217	GSTA4_HUMAN	glutathione S-transferase alpha 4	59	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity				0	Lung NSC(77;0.103)				Glutathione(DB00143)	TCCCGTCAATTTCAACCATGG	0.468													G	52850344	G	G	52850344	3	3	67	1	0	0	0	0	1	0	0	0	6833	1838	64	5	507	5	GSTA4	6	52850344	Missense_Mutation	SNP	T	TCGA-06-0877-01A-01W-0424-08	3275480	52850344	118264723	32	4470											
AMD1	262	broad.mit.edu	37	chr6	111210086	111210086	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tagcatgtttgtctccaagaGacgtttcattttgaagacat	8	7	2	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr6:111210086G>A	uc003puk.1	+	3	546	c.224G>A	c.(223-225)AGA>AAA	p.R75K	AMD1_uc011eay.1_Missense_Mutation_p.R6K|AMD1_uc011eaz.1_Missense_Mutation_p.R46K|AMD1_uc011eba.1_Intron|AMD1_uc003pul.1_Intron	NM_001634	NP_001625	P17707	DCAM_HUMAN	adenosylmethionine decarboxylase 1 isoform 1	75					spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			upper_aerodigestive_tract(1)	1		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)	GTCTCCAAGAGACGTTTCATT	0.393													A	111210086	A	A	111210086	3	1	67	1	0	0	0	0	1	0	0	0	566	942	33	3	234	3	AMD1	6	111210086	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	58359742	111210086	59904981	33	4471											
CCDC129	223075	broad.mit.edu	37	chr7	31614192	31614192	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attttgggagatagatccagTggagattctcttggatctgg	13	5	2	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr7:31614192T>C	uc003tcj.1	+	7	1427	c.434T>C	c.(433-435)GTG>GCG	p.V145A	CCDC129_uc011kad.1_Missense_Mutation_p.V155A|CCDC129_uc003tci.1_Missense_Mutation_p.V144A|CCDC129_uc011kae.1_Missense_Mutation_p.V171A|CCDC129_uc003tck.1_Missense_Mutation_p.V53A	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	145											0						ATAGATCCAGTGGAGATTCTC	0.443													C	31614192	C	C	31614192	3	2	67	1	0	0	0	0	1	0	0	0	2764	1696	59	4	456	4	CCDC129	7	31614192	Missense_Mutation	SNP	T	TCGA-06-0877-01A-01W-0424-08		31614192	127524471	34	4472											
NPTX2	4885	broad.mit.edu	37	chr7	98254242	98254242	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccaacccccaggcaatagcGcctttaagtcaccagatgcg	8	16	1	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr7:98254242G>A	uc003upl.2	+	3	829	c.652G>A	c.(652-654)GCC>ACC	p.A218T		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	218					synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			AGGCAATAGCGCCTTTAAGTC	0.582													A	98254242	A	A	98254242	3	1	67	1	0	0	0	0	1	0	0	0	10603	1087	38	1	662	1	NPTX2	7	98254242	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	66640050	98254242	60884421	35	4473											
SLC26A4	5172	broad.mit.edu	37	chr7	107350617	107350617	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagaaccaagtgaaatctcaAgagggtcaaggttccatttt	9	8	2	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr7:107350617A>G	uc003vep.2	+	19	2432	c.2208A>G	c.(2206-2208)CAA>CAG	p.Q736Q	SLC26A4_uc011kmb.1_Silent_p.Q323Q|SLC26A4_uc011kmc.1_Silent_p.Q297Q|SLC26A4_uc011kmd.1_Silent_p.Q305Q	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	736	Cytoplasmic (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						TGAAATCTCAAGAGGGTCAAG	0.363									Pendred_syndrome				G	107350617	G	G	107350617	2	3	67	1	0	0	0	0	0	0	0	1	14519	69	3	4		4	SLC26A4	7	107350617	Silent	SNP	A	TCGA-06-0877-01A-01W-0424-08	9096375	107350617	51788046	36	4474											
SHH	6469	broad.mit.edu	37	chr7	155599026	155599026	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtggatatgtgccttggactCgtagtacacccagtcgaagc	12	10	0	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr7:155599026C>T	uc003wmk.1	-	2	677	c.526G>A	c.(526-528)GAG>AAG	p.E176K	SHH_uc003wmh.1_RNA|SHH_uc003wmi.1_Missense_Mutation_p.E89K|SHH_uc003wmj.1_Missense_Mutation_p.E89K	NM_000193	NP_000184	Q15465	SHH_HUMAN	sonic hedgehog preproprotein	176			Missing (in HPE3).		androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of T cell differentiation in thymus|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|lung(1)	4	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCTTGGACTCGTAGTACACC	0.652													T	155599026	T	T	155599026	3	4	67	1	0	0	0	0	1	0	0	0	14279	893	31	2	870	2	SHH	7	155599026	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	48248409	155599026	3539637	37	4475			1	14		2	2	16	C		4.312378e-05
SHH	6469	broad.mit.edu	37	chr7	155599041	155599041	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggactcgtagtacacccagtCgaagccggcctccaccgcca	10	17	0	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr7:155599041C>T	uc003wmk.1	-	2	662	c.511G>A	c.(511-513)GAC>AAC	p.D171N	SHH_uc003wmh.1_RNA|SHH_uc003wmi.1_Missense_Mutation_p.D84N|SHH_uc003wmj.1_Missense_Mutation_p.D84N	NM_000193	NP_000184	Q15465	SHH_HUMAN	sonic hedgehog preproprotein	171			D -> H (in HPE3).		androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of T cell differentiation in thymus|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|lung(1)	4	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TACACCCAGTCGAAGCCGGCC	0.652													T	155599041	T	T	155599041	3	4	67	1	0	0	0	0	1	0	0	0	14279	884	31	2	885	2	SHH	7	155599041	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	15	155599041	3539622	38	4476			1	14		2	2	16	C		4.312378e-05
DLC1	10395	broad.mit.edu	37	chr8	12952442	12952442	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcctgaatccgggacttgaCccccgattttctgaagagcc	10	13	1	4			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr8:12952442C>T	uc003wwm.2	-	12	3796	c.3352G>A	c.(3352-3354)GTC>ATC	p.V1118I	DLC1_uc003wwk.1_Missense_Mutation_p.V681I|DLC1_uc003wwl.1_Missense_Mutation_p.V715I|DLC1_uc011kxx.1_Missense_Mutation_p.V607I	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1118	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CGGGACTTGACCCCCGATTTT	0.507													T	12952442	T	T	12952442	3	4	67	1	0	0	0	0	1	0	0	0	4550	507	18	3	1262	3	DLC1	8	12952442	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08		12952442	133411580	39	4477											
ELP3	55140	broad.mit.edu	37	chr8	28017799	28017799	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggctgggaaacattcttGtcatacgaagacccagatca	11	9	3	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr8:28017799G>A	uc003xgo.3	+	13	1459	c.1311G>A	c.(1309-1311)TTG>TTA	p.L437L	ELP3_uc003xgn.3_Silent_p.L422L|ELP3_uc011laq.1_Silent_p.L365L|ELP3_uc011lar.1_Silent_p.L345L|ELP3_uc011las.1_Silent_p.L318L|ELP3_uc011lat.1_Silent_p.L318L	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	elongation protein 3 homolog	437	N-acetyltransferase.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding				0		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		AAACATTCTTGTCATACGAAG	0.383													A	28017799	A	A	28017799	2	1	67	1	0	0	0	0	0	0	0	1	5081	1368	48	3		3	ELP3	8	28017799	Silent	SNP	G	TCGA-06-0877-01A-01W-0424-08	15065357	28017799	118346223	40	4478											
CHD7	55636	broad.mit.edu	37	chr8	61764695	61764695	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcgcagctataaaaggcaacAgatgaggcaagaggccctaa	12	9	0	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr8:61764695A>T	uc003xue.2	+	29	6260	c.5783A>T	c.(5782-5784)CAG>CTG	p.Q1928L		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1928					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAAAGGCAACAGATGAGGCAA	0.527													T	61764695	T	T	61764695	3	4	67	1	0	0	0	0	1	0	0	0	3330	188	7	5	5893	5	CHD7	8	61764695	Missense_Mutation	SNP	A	TCGA-06-0877-01A-01W-0424-08	33746896	61764695	84599327	41	4479											
SLCO5A1	81796	broad.mit.edu	37	chr8	70744582	70744582	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctggagcatggccaaggcGgaggacaccgagaaggtttt	15	9	0	1	rs145247874		TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr8:70744582G>A	uc003xyl.2	-	2	1034	c.327C>T	c.(325-327)TCC>TCT	p.S109S	SLCO5A1_uc010lzb.2_Silent_p.S109S|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Silent_p.S109S|SLCO5A1_uc010lzc.2_Silent_p.S109S	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	109	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TGGCCAAGGCGGAGGACACCG	0.622											OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	70744582	A	A	70744582	2	1	67	1	0	0	0	0	0	0	0	1	14731	1103	39	2		2	SLCO5A1	8	70744582	Silent	SNP	G	TCGA-06-0877-01A-01W-0424-08	8979887	70744582	75619440	42	4480											
RIMS2	9699	broad.mit.edu	37	chr8	105160868	105160868	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaaatgcaaagcagacaaatGggcatatcagggaagaacat	10	6	1	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr8:105160868G>C	uc003yls.2	+	23	3421	c.3180G>C	c.(3178-3180)ATG>ATC	p.M1060I	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.M1049I|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GCAGACAAATGGGCATATCAG	0.433										HNSCC(12;0.0054)			C	105160868	C	C	105160868	3	2	67	1	0	0	0	0	1	0	0	0	13368	1363	47	5		5	RIMS2	8	105160868	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	34416286	105160868	41203154	43	4481											
SLC24A2	25769	broad.mit.edu	37	chr9	19786746	19786746	+	Nonsense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccagacccatgaaaaggcctAagactcgaattaacttcagt	7	11	1	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr9:19786746A>C	uc003zoa.1	-	1	181	c.119T>G	c.(118-120)TTA>TGA	p.L40*	SLC24A2_uc003zob.1_Nonsense_Mutation_p.L40*	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	40					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GAAAAGGCCTAAGACTCGAAT	0.438													C	19786746	C	C	19786746	4	2	67	1	0	0	0	0	0	1	0	0	14466	372	13	5	1906	5	SLC24A2	9	19786746	Nonsense_Mutation	SNP	A	TCGA-06-0877-01A-01W-0424-08		19786746	121426685	44	4482											
TESK1	7016	broad.mit.edu	37	chr9	35609460	35609460	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggctgggctggggagccctgGaaccgggcccagcatagcct	17	13	0	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr9:35609460G>A	uc003zxa.2	+	10	1938	c.1602G>A	c.(1600-1602)TGG>TGA	p.W534*	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Nonsense_Mutation_p.W374*	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	534					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GGGAGCCCTGGAACCGGGCCC	0.692													A	35609460	A	A	35609460	4	1	67	1	0	0	0	0	0	1	0	0	15764	1183	41	3	1640	3	TESK1	9	35609460	Nonsense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	15822714	35609460	105603971	45	4483											
ADAMTS14	140766	broad.mit.edu	37	chr10	72517795	72517795	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaacagcctcgggcattgCgagggggataggccagacac	15	12	0	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr10:72517795C>T	uc001jrh.2	+	20	3015	c.3015C>T	c.(3013-3015)TGC>TGT	p.C1005C	ADAMTS14_uc001jrg.2_Silent_p.C1008C	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1005	TSP type-1 4.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						TCGGGCATTGCGAGGGGGATA	0.667													T	72517795	T	T	72517795	2	4	67	1	0	0	0	0	0	0	0	1	259	776	27	1		1	ADAMTS14	10	72517795	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08		72517795	63016952	46	4484											
EIF3A	8661	broad.mit.edu	37	chr10	120801816	120801816	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggaccccgatcatcatccaaCcctcgcctgggaccccggtc	9	19	2	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr10:120801816C>G	uc001ldu.2	-	19	3362	c.3216G>C	c.(3214-3216)GGG>GGC	p.G1072G	EIF3A_uc010qsu.1_Silent_p.G1038G|EIF3A_uc009xzg.1_Silent_p.G111G	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	1072	15.|Asp-rich.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CATCATCCAACCCTCGCCTGG	0.637													G	120801816	G	G	120801816	2	3	67	1	0	0	0	0	0	0	0	1	5012	494	18	5		5	EIF3A	10	120801816	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	48284021	120801816	14732931	47	4485											
DHX32	55760	broad.mit.edu	37	chr10	127527726	127527726	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ctgagtgctgaacagttgagGaagtaatcacgacaccactt	10	9	1	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr10:127527726G>C	uc001ljf.1	-	9	2216	c.1725C>G	c.(1723-1725)TTC>TTG	p.F575L	BCCIP_uc001ljd.3_Intron|DHX32_uc001lje.1_Missense_Mutation_p.F199L|DHX32_uc001ljg.1_Missense_Mutation_p.F575L|BCCIP_uc010qui.1_Intron|BCCIP_uc001ljc.3_Intron|BCCIP_uc010quj.1_Intron	NM_018180	NP_060650	Q7L7V1	DHX32_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32	575						mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AACAGTTGAGGAAGTAATCAC	0.453													C	127527726	C	C	127527726	3	2	67	1	0	0	0	0	1	0	0	0	4505	1165	41	5	518	5	DHX32	10	127527726	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	6725910	127527726	8007021	48	4486											
ELF5	2001	broad.mit.edu	37	chr11	34515184	34515184	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaacttgtactggtcgcagCagaactggagccactcccac	9	15	0	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr11:34515184C>T	uc001mvo.1	-	3	457	c.227G>A	c.(226-228)TGC>TAC	p.C76Y	ELF5_uc001mvp.1_Missense_Mutation_p.C66Y|ELF5_uc009ykd.1_Intron|ELF5_uc001mvq.1_Missense_Mutation_p.C66Y	NM_198381	NP_938195	Q9UKW6	ELF5_HUMAN	E74-like factor 5 ESE-2a	76	PNT.				cell proliferation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.0087)|all_hematologic(20;0.0384)				CTGGTCGCAGCAGAACTGGAG	0.527											OREG0020879	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	34515184	T	T	34515184	3	4	67	1	0	0	0	0	1	0	0	0	5057	710	25	3	590	3	ELF5	11	34515184	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08		34515184	100491332	49	4487											
OR5D13	390142	broad.mit.edu	37	chr11	55541628	55541628	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaagtgggcgccagaaaActttctccacctgtgcctcc	9	15	1	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr11:55541628A>T	uc010ril.1	+	1	715	c.715A>T	c.(715-717)ACT>TCT	p.T239S		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	239	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				GCGCCAGAAAACTTTCTCCAC	0.418													T	55541628	T	T	55541628	3	4	67	1	0	0	0	0	1	0	0	0	11154	43	2	5	717	5	OR5D13	11	55541628	Missense_Mutation	SNP	A	TCGA-06-0877-01A-01W-0424-08	21026444	55541628	79464888	50	4488											
OR5L2	26338	broad.mit.edu	37	chr11	55594866	55594866	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcagctctcggctccacaccCccgtgtactttttcctcagc	6	18	3	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr11:55594866C>A	uc001nhy.1	+	1	172	c.172C>A	c.(172-174)CCC>ACC	p.P58T		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				GCTCCACACCCCCGTGTACTT	0.468										HNSCC(27;0.073)			A	55594866	A	A	55594866	3	1	67	1	0	0	0	0	1	0	0	0	11171	623	22	5	174	5	OR5L2	11	55594866	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	53238	55594866	79411650	51	4489											
OR5W2	390148	broad.mit.edu	37	chr11	55681471	55681471	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagacggtgaataacactaaCtcattgacctgtgtatctga	8	8	2	4			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr11:55681471C>G	uc010rir.1	-	1	588	c.588G>C	c.(586-588)GAG>GAC	p.E196D		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATAACACTAACTCATTGACCT	0.383													G	55681471	G	G	55681471	3	3	67	1	0	0	0	0	1	0	0	0	11185	564	20	5	346	5	OR5W2	11	55681471	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	86605	55681471	79325045	52	4490											
OR9G9	504191	broad.mit.edu	37	chr11	56468275	56468275	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atgcccaggccatgtccataAagctgtgtgcattgctggta	11	10	0	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr11:56468275A>T	uc010rjn.1	+	1	412	c.412A>T	c.(412-414)AAG>TAG	p.K138*		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATGTCCATAAAGCTGTGTGC	0.493													T	56468275	T	T	56468275	4	4	67	1	0	0	0	0	0	1	0	0	11252	15	1	5	414	5	OR9G9	11	56468275	Nonsense_Mutation	SNP	A	TCGA-06-0877-01A-01W-0424-08	786804	56468275	78538241	53	4491											
OR9G9	504191	broad.mit.edu	37	chr11	56468515	56468515	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgctcatcctggcctcctacCtctttatcatcaccagtgtc	5	16	4	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr11:56468515C>A	uc010rjn.1	+	1	652	c.652C>A	c.(652-654)CTC>ATC	p.L218I		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	218	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCCTCCTACCTCTTTATCAT	0.532													A	56468515	A	A	56468515	3	1	67	1	0	0	0	0	1	0	0	0	11252	681	24	5	654	5	OR9G9	11	56468515	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	240	56468515	78538001	54	4492											
HTR3B	9177	broad.mit.edu	37	chr11	113815368	113815368	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	atcgtgttggtcaaattcctCcatgatgagcagcgtggtgg	13	8	1	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr11:113815368C>G	uc001pok.2	+	8	1048	c.981C>G	c.(979-981)CTC>CTG	p.L327L	HTR3B_uc001pol.2_Silent_p.L316L	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	327	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TCAAATTCCTCCATGATGAGC	0.557													G	113815368	G	G	113815368	2	3	67	1	0	0	0	0	0	0	0	1	7445	842	30	5		5	HTR3B	11	113815368	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	57346853	113815368	21191148	55	4493											
MAP3K12	7786	broad.mit.edu	37	chr12	53875972	53875972	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaaggtagatagtgactggCgcatgttcaggctctgaggc	15	7	2	4	rs149876591		TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr12:53875972C>T	uc001sdm.1	-	14	2332	c.2234G>A	c.(2233-2235)CGC>CAC	p.R745H	MAP3K12_uc001sdn.1_Missense_Mutation_p.R778H	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	745					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						TAGTGACTGGCGCATGTTCAG	0.512											OREG0021873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	53875972	T	T	53875972	3	4	67	1	0	0	0	0	1	0	0	0	9246	768	27	1	353	1	MAP3K12	12	53875972	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08		53875972	79975923	56	4494											
CUX2	23316	broad.mit.edu	37	chr12	111748125	111748125	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccccccagccttctatggCgccaagccccccacagcccc	6	23	1	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr12:111748125C>T	uc001tsa.1	+	15	1692	c.1539C>T	c.(1537-1539)GGC>GGT	p.G513G		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	513	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CCTTCTATGGCGCCAAGCCCC	0.741													T	111748125	T	T	111748125	2	4	67	1	0	0	0	0	0	0	0	1	4065	755	27	1		1	CUX2	12	111748125	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	57872153	111748125	22103770	57	4495											
TMEM132B	114795	broad.mit.edu	37	chr12	125834741	125834741	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttgggagtgtggtggtctacCcaacccaagatgatctgaag	13	8	2	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr12:125834741C>G	uc001uhe.1	+	2	804	c.796C>G	c.(796-798)CCA>GCA	p.P266A		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	266	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GGTGGTCTACCCAACCCAAGA	0.577													G	125834741	G	G	125834741	3	3	67	1	0	0	0	0	1	0	0	0	16043	623	22	5	802	5	TMEM132B	12	125834741	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	14086616	125834741	8017154	58	4496											
TBC1D4	9882	broad.mit.edu	37	chr13	75933904	75933904	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgatatactttgatacataCctgagaacaagaggagatat	8	5	0	5			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr13:75933904C>T	uc001vjl.1	-	3	1517	c.1170_splice	c.e3+1	p.Q390_splice	TBC1D4_uc010aer.2_Splice_Site_p.Q390_splice|TBC1D4_uc010aes.2_Splice_Site_p.Q390_splice	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4							cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		TTGATACATACCTGAGAACAA	0.313													T	75933904	T	T	75933904	5	4	67	1	0	0	0	0	0	0	1	0	15619	521	18	3	2801	3	TBC1D4	13	75933904	Splice_Site	SNP	C	TCGA-06-0877-01A-01W-0424-08		75933904	39235974	59	4497											
SERPINA1	5265	broad.mit.edu	37	chr14	94849558	94849558	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccagcaggaggatgccccacGagacagaagacggcattgtc	13	12	0	3	rs140814100		TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr14:94849558G>A	uc001ycx.3	-	2	278	c.17C>T	c.(16-18)TCG>TTG	p.S6L	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Missense_Mutation_p.S6L|SERPINA1_uc010aux.2_Missense_Mutation_p.S6L|SERPINA1_uc001ycy.3_Missense_Mutation_p.S6L|SERPINA1_uc010auy.2_Missense_Mutation_p.S6L|SERPINA1_uc001ycz.3_Missense_Mutation_p.S6L|SERPINA1_uc010auz.2_Missense_Mutation_p.S6L|SERPINA1_uc010ava.2_Missense_Mutation_p.S6L|SERPINA1_uc001ydb.3_Missense_Mutation_p.S6L|SERPINA1_uc010avb.2_Missense_Mutation_p.S6L|SERPINA1_uc001ydc.3_Missense_Mutation_p.S6L|SERPINA1_uc001yda.1_Missense_Mutation_p.S6L	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	6					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	GATGCCCCACGAGACAGAAGA	0.612									Alpha-1-Antitrypsin_Deficiency				A	94849558	A	A	94849558	3	1	67	1	0	0	0	0	1	0	0	0	14086	1059	37	2	1255	2	SERPINA1	14	94849558	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08		94849558	12499982	60	4498											
SLC12A1	6557	broad.mit.edu	37	chr15	48566793	48566793	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catttgattttgagattggcGtggttatagtcagaatcagc	11	5	2	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr15:48566793G>A	uc001zwn.3	+	20	2644	c.2428G>A	c.(2428-2430)GTG>ATG	p.V810M	SLC12A1_uc010uew.1_Missense_Mutation_p.V616M|SLC12A1_uc001zwq.3_Missense_Mutation_p.V581M|SLC12A1_uc001zwr.3_Missense_Mutation_p.V537M	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	810	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TGAGATTGGCGTGGTTATAGT	0.338													A	48566793	A	A	48566793	3	1	67	1	0	0	0	0	1	0	0	0	14382	1145	40	1	2602	1	SLC12A1	15	48566793	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08		48566793	53964599	61	4499											
ISLR2	57611	broad.mit.edu	37	chr15	74425374	74425374	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcgcaccgtggagccaggCgcactggccgtgctgagtca	16	13	1	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr15:74425374C>T	uc002axd.2	+	4	1048	c.279C>T	c.(277-279)GGC>GGT	p.G93G	ISLR2_uc002axe.2_Silent_p.G93G|ISLR2_uc010bjg.2_Silent_p.G93G|ISLR2_uc010bjf.2_Silent_p.G93G	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	93	Extracellular (Potential).|LRR 2.				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						TGGAGCCAGGCGCACTGGCCG	0.637													T	74425374	T	T	74425374	2	4	67	1	0	0	0	0	0	0	0	1	7859	755	27	1		1	ISLR2	15	74425374	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	25858581	74425374	28106018	62	4500											
PCSK6	5046	broad.mit.edu	37	chr15	101968175	101968175	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agcaacttctcccgcacaacGagtgccgtgtctgaaacaaa	8	13	2	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr15:101968175G>T	uc002bwy.2	-	7	1059	c.745C>A	c.(745-747)CGT>AGT	p.R249S	PCSK6_uc010bpd.2_Missense_Mutation_p.R119S|PCSK6_uc010bpe.2_Missense_Mutation_p.R249S|PCSK6_uc002bxa.2_Missense_Mutation_p.R249S|PCSK6_uc002bxb.2_Missense_Mutation_p.R249S|PCSK6_uc002bxc.1_Missense_Mutation_p.R249S|PCSK6_uc002bxd.1_Missense_Mutation_p.R249S|PCSK6_uc002bxe.2_Missense_Mutation_p.R249S|PCSK6_uc002bxg.1_Missense_Mutation_p.R249S	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	249	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCCGCACAACGAGTGCCGTGT	0.512													T	101968175	T	T	101968175	3	4	67	1	0	0	0	0	1	0	0	0	11604	1058	37	5	2711	5	PCSK6	15	101968175	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	27542801	101968175	563217	63	4501											
UBN1	29855	broad.mit.edu	37	chr16	4909917	4909917	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	taaagaagaagaaaaaagatGacacttatgacaaggagaag	10	3	0	7			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr16:4909917G>A	uc002cyb.2	+	6	958	c.619G>A	c.(619-621)GAC>AAC	p.D207N	UBN1_uc010uxw.1_Missense_Mutation_p.D207N|UBN1_uc002cyc.2_Missense_Mutation_p.D207N	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	207	Lys-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						GAAAAAAGATGACACTTATGA	0.443													A	4909917	A	A	4909917	3	1	67	1	0	0	0	0	1	0	0	0	16889	1290	45	3	637	3	UBN1	16	4909917	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08		4909917	85444836	64	4502											
SLC12A3	6559	broad.mit.edu	37	chr16	56928513	56928513	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaatgcaagatccgtgtgttCgtaggcggccagattaacag	12	8	0	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr16:56928513C>T	uc010ccm.2	+	22	2621	c.2592C>T	c.(2590-2592)TTC>TTT	p.F864F	SLC12A3_uc002ekd.3_Silent_p.F873F|SLC12A3_uc010ccn.2_Silent_p.F872F	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	864	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TCCGTGTGTTCGTAGGCGGCC	0.582													T	56928513	T	T	56928513	2	4	67	1	0	0	0	0	0	0	0	1	14384	883	31	2		2	SLC12A3	16	56928513	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	52018596	56928513	33426240	65	4503											
CPNE7	27132	broad.mit.edu	37	chr16	89656340	89656340	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgctttggggtttggagcccGgatccctcccaagtatgagg	14	11	0	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr16:89656340G>A	uc002fnp.2	+	13	1452	c.1322G>A	c.(1321-1323)CGG>CAG	p.R441Q	CPNE7_uc002fnq.2_Missense_Mutation_p.R366Q	NM_014427	NP_055242	Q9UBL6	CPNE7_HUMAN	copine 7 isoform b	441	VWFA.				lipid metabolic process		transporter activity				0		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		TTTGGAGCCCGGATCCCTCCC	0.622													A	89656340	A	A	89656340	3	1	67	1	0	0	0	0	1	0	0	0	3817	1116	39	2	1372	2	CPNE7	16	89656340	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	32727827	89656340	698413	66	4504											
TRPV2	51393	broad.mit.edu	37	chr17	16321183	16321183	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaaagggaacaggtgccagGtgagacagcaagtgggggca	18	7	0	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr17:16321183G>A	uc002gpy.2	+	2	567	c.200_splice	c.e2+1	p.S67_splice	TRPV2_uc002gpz.2_Splice_Site	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,						sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CAGGTGCCAGGTGAGACAGCA	0.617													A	16321183	A	A	16321183	5	1	67	1	0	0	0	0	0	0	1	0	16593	1275	44	3	203	3	TRPV2	17	16321183	Splice_Site	SNP	G	TCGA-06-0877-01A-01W-0424-08		16321183	64874027	67	4505											
EFCAB5	374786	broad.mit.edu	37	chr17	28434861	28434861	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcctgatgcagatcattcccGaactgaagtatggaaatttg	9	8	1	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr17:28434861G>A	uc002het.2	+	23	4523	c.4331G>A	c.(4330-4332)CGA>CAA	p.R1444Q	EFCAB5_uc010cse.2_Missense_Mutation_p.R1199Q|EFCAB5_uc010csf.2_Missense_Mutation_p.R795Q	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1444							calcium ion binding			ovary(1)|skin(1)	2						GATCATTCCCGAACTGAAGTA	0.308													A	28434861	A	A	28434861	3	1	67	1	0	0	0	0	1	0	0	0	4938	1058	37	2	4588	2	EFCAB5	17	28434861	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	12113678	28434861	52760349	68	4506											
ERBB2	2064	broad.mit.edu	37	chr17	37884124	37884124	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agaaccccgagtacttgacaCcccagggaggagctgcccct	11	15	0	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr17:37884124C>A	uc002hso.2	+	27	3833	c.3595C>A	c.(3595-3597)CCC>ACC	p.P1199T	ERBB2_uc002hsm.2_Missense_Mutation_p.P1169T|ERBB2_uc010cwa.2_Missense_Mutation_p.P1184T|ERBB2_uc002hsp.2_Missense_Mutation_p.P1002T|ERBB2_uc010cwb.2_3'UTR|ERBB2_uc010wek.1_Missense_Mutation_p.P923T	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	1199	Cytoplasmic (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GTACTTGACACCCCAGGGAGG	0.622		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			A	37884124	A	A	37884124	3	1	67	1	0	0	0	0	1	0	0	0	5206	507	18	5	3701	5	ERBB2	17	37884124	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	9449263	37884124	43311086	69	4507											
AOC3	8639	broad.mit.edu	37	chr17	41003669	41003669	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcagtggagttgcagctGcctcccaaggctgcagccct	11	14	1	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr17:41003669G>A	uc002ibv.2	+	1	469	c.309G>A	c.(307-309)CTG>CTA	p.L103L		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	103	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	AGTTGCAGCTGCCTCCCAAGG	0.672													A	41003669	A	A	41003669	2	1	67	1	0	0	0	0	0	0	0	1	728	1306	46	3		3	AOC3	17	41003669	Silent	SNP	G	TCGA-06-0877-01A-01W-0424-08	3119545	41003669	40191541	70	4508											
KIF2B	84643	broad.mit.edu	37	chr17	51901522	51901522	+	Frame_Shift_Del	DEL	C	-	-													tggaagaagaagctgcaagtCcttgaggatggcaatcagca							TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr17:51901522delC	uc002iua.2	+	1	1284	c.1128delC	c.(1126-1128)GTCfs	p.V376fs	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	376	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AGCTGCAAGTCCTTGAGGATG	0.468													-	51901522	-	-	51901522	7	5	67	1	0	1	0	1	0	0	0	0	8298	842	30	0	1130	0	KIF2B	17	51901522	Frame_Shift_Del	DEL	C	TCGA-06-0877-01A-01W-0424-08	10897853	51901522	29293688	71	4509											
GALNT1	2589	broad.mit.edu	37	chr18	33257555	33257555	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcatttgctttgtctctagGtgtaaaacaaaggtgtatcc	10	7	1	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr18:33257555G>A	uc010dmu.2	+	4	368	c.315G>A	c.(313-315)GGG>GGA	p.G105G	GALNT1_uc002kyz.3_Silent_p.G45G|GALNT1_uc002kzb.2_Silent_p.G105G	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	105	Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						TTGTCTCTAGGTGTAAAACAA	0.383													A	33257555	A	A	33257555	2	1	67	1	0	0	0	0	0	0	0	1	6207	1275	44	3		3	GALNT1	18	33257555	Silent	SNP	G	TCGA-06-0877-01A-01W-0424-08		33257555	44819693	72	4510											
PARD6G	84552	broad.mit.edu	37	chr18	77918374	77918374	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatacggggcggaagtcgcgCgggaggccgatgtccaggtg	20	9	0	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr18:77918374C>T	uc002lny.2	-	3	577	c.411G>A	c.(409-411)CCG>CCA	p.P137P	LOC100130522_uc002lnx.2_Intron|LOC100130522_uc010xfn.1_Intron|LOC100130522_uc010xfo.1_Intron	NM_032510	NP_115899	Q9BYG4	PAR6G_HUMAN	PAR-6 gamma protein	137	Pseudo-CRIB.|Interaction with PARD3 and CDC42 (By similarity).				cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding				0		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)		GGAAGTCGCGCGGGAGGCCGA	0.731													T	77918374	T	T	77918374	2	4	67	1	0	0	0	0	0	0	0	1	11447	755	27	1		1	PARD6G	18	77918374	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	44660819	77918374	158874	73	4511											
C3	718	broad.mit.edu	37	chr19	6680227	6680227	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggataagctctacattaaaGtattggtgaactttgaaagc	9	5	1	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:6680227G>T	uc002mfm.2	-	36	4460	c.4398C>A	c.(4396-4398)TAC>TAA	p.Y1466*	C3_uc002mfl.2_Nonsense_Mutation_p.Y202*	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1466					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTACATTAAAGTATTGGTGAA	0.542													T	6680227	T	T	6680227	4	4	67	1	0	0	0	0	0	1	0	0	2204	1024	36	5	617	5	C3	19	6680227	Nonsense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08		6680227	52448756	74	4512											
EMR1	2015	broad.mit.edu	37	chr19	6913826	6913826	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caaatatcactccggctgttCggacggaatacttaggtagg	11	9	1	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:6913826C>T	uc002mfw.2	+	11	1323	c.1285C>T	c.(1285-1287)CGG>TGG	p.R429W	EMR1_uc010dvc.2_Missense_Mutation_p.R429W|EMR1_uc010dvb.2_Missense_Mutation_p.R377W|EMR1_uc010xji.1_Missense_Mutation_p.R288W|EMR1_uc010xjj.1_Missense_Mutation_p.R252W	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	429	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TCCGGCTGTTCGGACGGAATA	0.498													T	6913826	T	T	6913826	3	4	67	1	0	0	0	0	1	0	0	0	5104	875	31	2	1327	2	EMR1	19	6913826	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	233599	6913826	52215157	75	4513											
GMIP	51291	broad.mit.edu	37	chr19	19745707	19745707	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggcacagccgctccacaCggacccgggacccgctgacc	11	20	0	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:19745707C>T	uc002nnd.2	-	17	1898	c.1781G>A	c.(1780-1782)CGT>CAT	p.R594H	GMIP_uc010xrb.1_Missense_Mutation_p.R568H|GMIP_uc010xrc.1_Missense_Mutation_p.R565H	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	594	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						CCGCTCCACACGGACCCGGGA	0.592													T	19745707	T	T	19745707	3	4	67	1	0	0	0	0	1	0	0	0	6491	536	19	1	1151	1	GMIP	19	19745707	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	12831881	19745707	39383276	76	4514											
CD22	933	broad.mit.edu	37	chr19	35837554	35837554	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtttggggtcggggagcGgcctcaggcacaagaaaatg	16	9	1	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:35837554G>A	uc010edt.2	+	14	2575	c.2498G>A	c.(2497-2499)CGG>CAG	p.R833Q	CD22_uc010xst.1_Missense_Mutation_p.R661Q|CD22_uc010edu.2_Missense_Mutation_p.R745Q|CD22_uc010edv.2_3'UTR|CD22_uc002nzb.3_Missense_Mutation_p.R656Q|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	833	Cytoplasmic (Potential).				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GTCGGGGAGCGGCCTCAGGCA	0.547													A	35837554	A	A	35837554	3	1	67	1	0	0	0	0	1	0	0	0	2985	1116	39	2	2548	2	CD22	19	35837554	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	16091847	35837554	23291429	77	4515											
SIPA1L3	23094	broad.mit.edu	37	chr19	38633315	38633315	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agcttctccacccccggttcGgccacctacgtgagatacaa	8	16	1	1	rs142547881		TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:38633315G>T	uc002ohk.2	+	12	4007	c.3498G>T	c.(3496-3498)TCG>TCT	p.S1166S		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1166					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCCCCGGTTCGGCCACCTACG	0.468											OREG0025445	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	38633315	T	T	38633315	2	4	67	1	0	0	0	0	0	0	0	1	14331	1103	39	5		5	SIPA1L3	19	38633315	Silent	SNP	G	TCGA-06-0877-01A-01W-0424-08	2795761	38633315	20495668	78	4516											
LGALS13	29124	broad.mit.edu	37	chr19	40097889	40097889	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcaatggcatacgcatttaCggctttgtccatcgaatccc	8	12	1	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:40097889C>T	uc002omb.2	+	4	370	c.330C>T	c.(328-330)TAC>TAT	p.Y110Y		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13	110	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			TACGCATTTACGGCTTTGTCC	0.463													T	40097889	T	T	40097889	2	4	67	1	0	0	0	0	0	0	0	1	8740	547	19	1		1	LGALS13	19	40097889	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	1464574	40097889	19031094	79	4517											
RUVBL2	10856	broad.mit.edu	37	chr19	49507675	49507675	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaagacggccatcgccatgGgtaagaaacctcccagggca	13	12	0	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:49507675G>A	uc002plr.1	+	4	278	c.265G>A	c.(265-267)GGC>AGC	p.G89S	RUVBL2_uc002plq.1_Missense_Mutation_p.G44S|RUVBL2_uc010yab.1_Missense_Mutation_p.G89S|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Missense_Mutation_p.G44S|RUVBL2_uc010yac.1_Missense_Mutation_p.G44S	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	89					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		CATCGCCATGGGTAAGAAACC	0.468													A	49507675	A	A	49507675	3	1	67	1	0	0	0	0	1	0	0	0	13753	1246	43	3	279	3	RUVBL2	19	49507675	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	9409786	49507675	9621308	80	4518											
ZNF534	147658	broad.mit.edu	37	chr19	52942496	52942496	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcggaattcacaccttgcgCgacataggaaaattcatact	8	10	2	0			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:52942496C>T	uc002pzk.2	+	4	1883	c.1822C>T	c.(1822-1824)CGA>TGA	p.R608*	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Nonsense_Mutation_p.R595*	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	608	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACACCTTGCGCGACATAGGAA	0.423													T	52942496	T	T	52942496	4	4	67	1	0	0	0	0	0	1	0	0	17970	760	27	1	1836	1	ZNF534	19	52942496	Nonsense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	3434821	52942496	6186487	81	4519											
ZSCAN5B	342933	broad.mit.edu	37	chr19	56701664	56701664	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccatctgggtgactgacCgggcccgcagggcctgggga	18	12	1	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:56701664C>T	uc010ygh.1	-	4	1020	c.1020G>A	c.(1018-1020)CCG>CCA	p.P340P		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	340					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGTGACTGACCGGGCCCGCAG	0.542													T	56701664	T	T	56701664	2	4	67	1	0	0	0	0	0	0	0	1	18236	639	23	2		2	ZSCAN5B	19	56701664	Silent	SNP	C	TCGA-06-0877-01A-01W-0424-08	3759168	56701664	2427319	82	4520											
RPS5	6193	broad.mit.edu	37	chr19	58904370	58904370	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgcagtgaaggagaagtatGccaagtacctgcctcacagt	11	9	1	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr19:58904370G>T	uc002qsn.2	+	3	208	c.136G>T	c.(136-138)GCC>TCC	p.A46S	RPS5_uc002qso.2_Missense_Mutation_p.A46S	NM_001009	NP_001000	P46782	RS5_HUMAN	ribosomal protein S5	46					endocrine pancreas development|regulation of translational fidelity|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|structural constituent of ribosome				0		all_cancers(17;1.71e-22)|all_epithelial(17;1.69e-16)|Lung NSC(17;2.25e-06)|all_lung(17;9.97e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Breast(46;0.0194)|Ovarian(87;0.0443)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.171)|GBM - Glioblastoma multiforme(193;0.0323)|Lung(386;0.0543)|LUSC - Lung squamous cell carcinoma(496;0.176)		GGAGAAGTATGCCAAGTACCT	0.557													T	58904370	T	T	58904370	3	4	67	1	0	0	0	0	1	0	0	0	13648	1319	46	5	142	5	RPS5	19	58904370	Missense_Mutation	SNP	G	TCGA-06-0877-01A-01W-0424-08	2202706	58904370	224613	83	4521											
KIF16B	55614	broad.mit.edu	37	chr20	16407806	16407806	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attcacagagcactgggaccCactcaggggtatcagagtca	11	11	4	2			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr20:16407806C>A	uc002wpg.1	-	15	1713	c.1555G>T	c.(1555-1557)GGG>TGG	p.G519W	KIF16B_uc010gch.1_Missense_Mutation_p.G519W|KIF16B_uc010gci.1_Missense_Mutation_p.G519W|KIF16B_uc010gcj.1_Missense_Mutation_p.G519W	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	519	FHA.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CACTGGGACCCACTCAGGGGT	0.428													A	16407806	A	A	16407806	3	1	67	1	0	0	0	0	1	0	0	0	8278	594	21	5	2446	5	KIF16B	20	16407806	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08		16407806	46617714	84	4522											
DIDO1	11083	broad.mit.edu	37	chr20	61542712	61542712	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacaggcatgctcctcctgcCgcggcgccgcgcaatggtca	13	16	1	0	rs138139875		TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr20:61542712C>T	uc002ydr.1	-	3	517	c.253G>A	c.(253-255)GGC>AGC	p.G85S	DIDO1_uc002yds.1_Missense_Mutation_p.G85S|DIDO1_uc002ydt.1_Missense_Mutation_p.G85S|DIDO1_uc002ydu.1_Missense_Mutation_p.G85S|DIDO1_uc002ydv.1_Missense_Mutation_p.G85S|DIDO1_uc002ydw.1_Missense_Mutation_p.G85S|DIDO1_uc002ydx.1_Missense_Mutation_p.G85S|DIDO1_uc011aao.1_Missense_Mutation_p.G85S	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	85					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTCCTCCTGCCGCGGCGCCGC	0.701													T	61542712	T	T	61542712	3	4	67	1	0	0	0	0	1	0	0	0	4522	652	23	2	6655	2	DIDO1	20	61542712	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	45134906	61542712	1482808	85	4523											
COL6A1	1291	broad.mit.edu	37	chr21	47412280	47412280	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtttctcttcatcccaggggAacccaggacctgacggtgcc	11	14	2	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr21:47412280A>T	uc002zhu.1	+	18	1342	c.1240A>T	c.(1240-1242)AAC>TAC	p.N414Y		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	414	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	ATCCCAGGGGAACCCAGGACC	0.637													T	47412280	T	T	47412280	3	4	67	1	0	0	0	0	1	0	0	0	3699	246	9	5	1310	5	COL6A1	21	47412280	Missense_Mutation	SNP	A	TCGA-06-0877-01A-01W-0424-08		47412280	717615	86	4524											
HIRA	7290	broad.mit.edu	37	chr22	19318996	19318996	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggatgtcgagctgttcctgAcactcggtgaagaggcgctg	15	9	0	3			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr22:19318996A>G	uc002zpf.1	-	25	3241	c.3021T>C	c.(3019-3021)TGT>TGC	p.C1007C	HIRA_uc011agx.1_Missense_Mutation_p.S844P|HIRA_uc010grn.1_Silent_p.C800C|HIRA_uc010gro.1_Silent_p.C963C	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	1007	Interaction with histone H4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					GCTGTTCCTGACACTCGGTGA	0.617													G	19318996	G	G	19318996	2	3	67	1	0	0	0	0	0	0	0	1	7120	273	10	4		4	HIRA	22	19318996	Silent	SNP	A	TCGA-06-0877-01A-01W-0424-08		19318996	31985570	87	4525											
VPREB1	7441	broad.mit.edu	37	chr22	22599423	22599423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcccttggaaccacaatcCgcctcacctgcaccctgagg	9	18	1	1			TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chr22:22599423C>T	uc002zvx.1	+	2	138	c.112C>T	c.(112-114)CGC>TGC	p.R38C	LOC96610_uc011aim.1_Intron	NM_007128	NP_009059	P12018	VPREB_HUMAN	immunoglobulin iota chain precursor	38	Framework-1.|Ig-like V-type.				immune response	extracellular region	antigen binding|protein binding				0	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		AACCACAATCCGCCTCACCTG	0.632													T	22599423	T	T	22599423	3	4	67	1	0	0	0	0	1	0	0	0	17183	652	23	2	118	2	VPREB1	22	22599423	Missense_Mutation	SNP	C	TCGA-06-0877-01A-01W-0424-08	3280427	22599423	28705143	88	4526											
P2RY4	5030	broad.mit.edu	37	chrX	69479145	69479145	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caatagaaaagaaagcggacGaacttgcagatctcagtgcc	10	9	1	3	rs146718292	byFrequency	TCGA-06-0877-01A-01W-0424-08	TCGA-06-0877-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	dda2b842-fd8b-4d14-9aa5-3cd3abc0a0e1	623be9ba-8b29-4e70-8378-f89e54c6090a	g.chrX:69479145G>A	uc004dxz.1	-	1	510	c.330C>T	c.(328-330)TTC>TTT	p.F110F		NM_002565	NP_002556	P51582	P2RY4_HUMAN	pyrimidinergic receptor P2Y4	110	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1						GAAAGCGGACGAACTTGCAGA	0.542													A	69479145	A	A	69479145	2	1	67	1	0	0	0	0	0	0	0	1	11353	1049	37	2		2	P2RY4	23	69479145	Silent	SNP	G	TCGA-06-0877-01A-01W-0424-08		69479145	85791415	89	4527											
KAZ	23254	broad.mit.edu	37	chr1	15428142	15428142	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cctttcagaaccacctggttGatgggcggatgctgaattcc	11	11	1	3			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr1:15428142G>A	uc001avm.3	+	11	1932	c.1651G>A	c.(1651-1653)GAT>AAT	p.D551N	KAZ_uc001avs.3_5'UTR	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	551	SAM 2.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						CCACCTGGTTGATGGGCGGAT	0.577													A	15428142	A	A	15428142	3	1	68	1	0	0	0	0	1	0	0	0	7988	1290	45	3	1949	3	KAZ	1	15428142	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08		15428142	233822479	1	4528											
HSPG2	3339	broad.mit.edu	37	chr1	22206668	22206668	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgcaaccagagcaggtgcCcaggtagggcccaccaggca	13	13	0	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr1:22206668C>T	uc001bfj.2	-	17	2315	c.2275G>A	c.(2275-2277)GGC>AGC	p.G759S	HSPG2_uc009vqd.2_Missense_Mutation_p.G760S	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	759	Laminin EGF-like 1; second part.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GAGCAGGTGCCCAGGTAGGGC	0.577													T	22206668	T	T	22206668	3	4	68	1	0	0	0	0	1	0	0	0	7430	623	22	3	11224	3	HSPG2	1	22206668	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08	6778526	22206668	227043953	2	4529											
GBP5	115362	broad.mit.edu	37	chr1	89729595	89729595	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaggatgcttccaggttccGtttacaaatgtcattctgtt	9	9	2	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr1:89729595G>A	uc001dnc.2	-	9	1723	c.1186C>T	c.(1186-1188)CGG>TGG	p.R396W	GBP5_uc001dnd.2_Missense_Mutation_p.R396W|GBP5_uc001dne.1_Missense_Mutation_p.R396W	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	396						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		TCCAGGTTCCGTTTACAAATG	0.378													A	89729595	A	A	89729595	3	1	68	1	0	0	0	0	1	0	0	0	6277	1144	40	1	590	1	GBP5	1	89729595	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08	67522927	89729595	159521026	3	4530											
AMY2B	280	broad.mit.edu	37	chr1	104122114	104122114	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaattcatgctgaatctAaattataaaatttaaaatta	3	4	2	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr1:104122114A>C	uc001duq.2	+	12	2144	c.1528A>C	c.(1528-1530)AAA>CAA	p.K510Q	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.K510Q|AMY2B_uc001dus.1_Intron	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	510					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TGCTGAATCtaaattataaaa	0.284													C	104122114	C	C	104122114	3	2	68	1	0	0	0	0	1	0	0	0	595	363	13	5	1566	5	AMY2B	1	104122114	Missense_Mutation	SNP	A	TCGA-06-0878-01A-01W-0424-08	14392519	104122114	145128507	4	4531											
FCRL3	115352	broad.mit.edu	37	chr1	157667597	157667597	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taactattaggaagctgtttTccatccttgtagtaaacctt	6	8	0	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr1:157667597T>C	uc001frb.2	-	5	703	c.411A>G	c.(409-411)GGA>GGG	p.G137G	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.G137G|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Silent_p.G137G	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	137	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					GAAGCTGTTTTCCATCCTTGT	0.363													C	157667597	C	C	157667597	2	2	68	1	0	0	0	0	0	0	0	1	5796	1770	62	4		4	FCRL3	1	157667597	Silent	SNP	T	TCGA-06-0878-01A-01W-0424-08	53545483	157667597	91583024	5	4532											
ZNF692	55657	broad.mit.edu	37	chr1	249148230	249148230	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gagaaagacttctggtggatGtgctggtactttttgtggtg	15	4	1	2			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr1:249148230G>T	uc001ifc.1	-	10	1226	c.1059C>A	c.(1057-1059)CAC>CAA	p.H353Q	ZNF692_uc001iez.1_Missense_Mutation_p.H75Q|ZNF692_uc001ifa.1_Missense_Mutation_p.H75Q|ZNF692_uc001ifb.1_Missense_Mutation_p.H149Q|ZNF692_uc001ifd.1_Missense_Mutation_p.H352Q|ZNF692_uc001ife.1_RNA|ZNF692_uc001iff.1_Missense_Mutation_p.H308Q|ZNF692_uc010pzr.1_Missense_Mutation_p.H358Q	NM_017865	NP_060335	Q9BU19	ZN692_HUMAN	zinc finger protein 692 isoform 2	353	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			TCTGGTGGATGTGCTGGTACT	0.512													T	249148230	T	T	249148230	3	4	68	1	0	0	0	0	1	0	0	0	18094	1368	48	5	512	5	ZNF692	1	249148230	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08	91480633	249148230	102391	6	4533											
ALLC	55821	broad.mit.edu	37	chr2	3743415	3743415	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	catcgcttttgggggtgtctGtgtaggatttagtaatgcta	13	5	1	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr2:3743415G>T	uc010ewt.2	+	8	781	c.620G>T	c.(619-621)TGT>TTT	p.C207F	ALLC_uc002qyf.2_5'UTR	NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	226							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		GGGGGTGTCTGTGTAGGATTT	0.448										HNSCC(21;0.051)			T	3743415	T	T	3743415	3	4	68	1	0	0	0	0	1	0	0	0	534	1377	48	5	646	5	ALLC	2	3743415	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08		3743415	239455958	7	4534											
TMEM182	130827	broad.mit.edu	37	chr2	103379127	103379133	+	Frame_Shift_Del	DEL	ATTTGGA	-	-													tggaagagaatgactccaatAtttggaagttctggtacagt							TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr2:103379127_103379133delATTTGGA	uc010fjb.2	+	2	401_407	c.214_220delATTTGGA	c.(214-222)ATTTGGAAGfs	p.I72fs	TMEM182_uc002tcc.3_Frame_Shift_Del_p.I29fs|TMEM182_uc002tcd.3_5'UTR	NM_144632	NP_653233	Q6ZP80	TM182_HUMAN	transmembrane protein 182 precursor	72_74	Extracellular (Potential).					integral to membrane					0						TGACTCCAATATTTGGAAGTTCTGGTA	0.362													-	103379133	-	-	103379127	7	5	68	1	0	1	0	1	0	0	0	0	16098	449	16	0	220	0	TMEM182	2	103379127	Frame_Shift_Del	DEL	ATTTGGA	TCGA-06-0878-01A-01W-0424-08	99635712	103379127	139820246	8	4535											
ITGB6	3694	broad.mit.edu	37	chr2	161025770	161025770	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacagcgaagatcaataacaCgttgttttgtaccagtttat	7	7	1	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr2:161025770C>T	uc002ubh.2	-	7	986	c.970G>A	c.(970-972)GTG>ATG	p.V324M	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Missense_Mutation_p.V324M|ITGB6_uc010zcq.1_Missense_Mutation_p.V282M|ITGB6_uc010fov.1_Missense_Mutation_p.V324M	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	324	Extracellular (Potential).|VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						ATCAATAACACGTTGTTTTGT	0.294													T	161025770	T	T	161025770	3	4	68	1	0	0	0	0	1	0	0	0	7899	536	19	1	1432	1	ITGB6	2	161025770	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08	57646643	161025770	82173603	9	4536											
DNAH7	56171	broad.mit.edu	37	chr2	196865488	196865488	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgacagctttaatcatgacGtcataaacatttagaaagat	6	7	2	4			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr2:196865488G>A	uc002utj.3	-	12	1394	c.1293C>T	c.(1291-1293)GAC>GAT	p.D431D		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	431	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TAATCATGACGTCATAAACAT	0.338													A	196865488	A	A	196865488	2	1	68	1	0	0	0	0	0	0	0	1	4606	1136	40	1		1	DNAH7	2	196865488	Silent	SNP	G	TCGA-06-0878-01A-01W-0424-08	35839718	196865488	46333885	10	4537											
IRS1	3667	broad.mit.edu	37	chr2	227660808	227660810	+	In_Frame_Del	DEL	GCT	-	-													ctctggagggtgcagcaaggGctgctgctgctgctgctgct							TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr2:227660808_227660810delGCT	uc002voh.3	-	1	2697_2699	c.2645_2647delAGC	c.(2644-2649)CAGCCC>CCC	p.Q882del		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	882	Poly-Gln.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		TGCAGCAAGGgctgctgctgctg	0.557													-	227660810	-	-	227660808	7	5	68	1	0	1	0	1	0	0	0	0	7840	1203	42	0	1085	0	IRS1	2	227660808	In_Frame_Del	DEL	GCT	TCGA-06-0878-01A-01W-0424-08	30795320	227660808	15538565	11	4538											
FBLN2	2199	broad.mit.edu	37	chr3	13672223	13672223	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatgagtgtgaggcccagcGctgcagccaggagtgtgcca	16	10	0	2			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr3:13672223G>A	uc011avb.1	+	14	2977	c.2852G>A	c.(2851-2853)CGC>CAC	p.R951H	FBLN2_uc011auz.1_Missense_Mutation_p.R977H|FBLN2_uc011ava.1_Missense_Mutation_p.R998H|FBLN2_uc011avc.1_Missense_Mutation_p.R998H	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	951	EGF-like 8; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GAGGCCCAGCGCTGCAGCCAG	0.607													A	13672223	A	A	13672223	3	1	68	1	0	0	0	0	1	0	0	0	5699	1087	38	1	1737	1	FBLN2	3	13672223	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08		13672223	184350207	12	4539											
ATP11B	23200	broad.mit.edu	37	chr3	182585181	182585181	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taggattggtattgtgtttaTtggcaattctgaagaaacta	10	3	1	2			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr3:182585181T>C	uc003flb.2	+	15	1894	c.1637T>C	c.(1636-1638)ATT>ACT	p.I546T	ATP11B_uc003flc.2_Missense_Mutation_p.I130T	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	546	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			ATTGTGTTTATTGGCAATTCT	0.294													C	182585181	C	C	182585181	3	2	68	1	0	0	0	0	1	0	0	0	1120	1493	52	4	1695	4	ATP11B	3	182585181	Missense_Mutation	SNP	T	TCGA-06-0878-01A-01W-0424-08	168912958	182585181	15437249	13	4540											
CTBP1	1487	broad.mit.edu	37	chr4	1206064	1206064	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcgtggtctctatccgcctcGggcttgacggtttggccagg	15	12	1	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr4:1206064G>C	uc003gcv.1	-	9	1452	c.1287C>G	c.(1285-1287)CCC>CCG	p.P429P	uc003gcs.1_RNA|CTBP1_uc003gct.1_Silent_p.P410P|CTBP1_uc003gcu.1_Silent_p.P418P|CTBP1_uc003gcw.2_Silent_p.P104P	NM_001328	NP_001319	Q13363	CTBP1_HUMAN	C-terminal binding protein 1 isoform 1	429					interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		TATCCGCCTCGGGCTTGACGG	0.692													C	1206064	C	C	1206064	2	2	68	1	0	0	0	0	0	0	0	1	3997	1103	39	5		5	CTBP1	4	1206064	Silent	SNP	G	TCGA-06-0878-01A-01W-0424-08		1206064	189948212	14	4541											
CLNK	116449	broad.mit.edu	37	chr4	10515205	10515205	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctctgaggagaacagggctgCatgcctcctctatgatctgg	12	11	3	3			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr4:10515205C>A	uc003gmo.3	-	16	926	c.789G>T	c.(787-789)ATG>ATT	p.M263I		NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	263					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						AACAGGGCTGCATGCCTCCTC	0.502													A	10515205	A	A	10515205	3	1	68	1	0	0	0	0	1	0	0	0	3547	710	25	5	513	5	CLNK	4	10515205	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08	9309141	10515205	180639071	15	4542											
DCHS2	54798	broad.mit.edu	37	chr4	155252747	155252747	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaggtcaccttctcctaattCacagaacagagacttgagaa	7	10	3	3			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr4:155252747C>T	uc003inw.2	-	10	2353	c.2353G>A	c.(2353-2355)GAA>AAA	p.E785K	DCHS2_uc003inx.2_Intron	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	785	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		tctcctaattcacagaaCAGA	0.219													T	155252747	T	T	155252747	3	4	68	1	0	0	0	0	1	0	0	0	4288	835	29	3	6557	3	DCHS2	4	155252747	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08	144737542	155252747	35901529	16	4543											
CTNND2	1501	broad.mit.edu	37	chr5	11022883	11022883	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgtcaccaggtaacttacttAtctcctttgcttttggagat	7	10	2	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr5:11022883A>C	uc003jfa.1	-	17	3142	c.2997T>G	c.(2995-2997)GAT>GAG	p.D999E	CTNND2_uc010itt.2_Missense_Mutation_p.D908E|CTNND2_uc011cmy.1_Missense_Mutation_p.D662E|CTNND2_uc011cmz.1_Missense_Mutation_p.D566E|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.D591E	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	999	ARM 9.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TAACTTACTTATCTCCTTTGC	0.488													C	11022883	C	C	11022883	3	2	68	1	0	0	0	0	1	0	0	0	4020	446	16	5	704	5	CTNND2	5	11022883	Missense_Mutation	SNP	A	TCGA-06-0878-01A-01W-0424-08		11022883	169892377	17	4544											
PCDHA8	56140	broad.mit.edu	37	chr5	140222517	140222517	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagttccaggtgagcgcGcgcgacgcgggcgtgccgcc	17	15	0	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr5:140222517G>A	uc003lhs.2	+	1	1611	c.1611G>A	c.(1609-1611)GCG>GCA	p.A537A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.A537A	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	537	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGAGCGCGCGCGACGCGG	0.667													A	140222517	A	A	140222517	2	1	68	1	0	0	0	0	0	0	0	1	11530	1074	38	1		1	PCDHA8	5	140222517	Silent	SNP	G	TCGA-06-0878-01A-01W-0424-08	129199634	140222517	40692743	18	4545											
DOCK2	1794	broad.mit.edu	37	chr5	169122848	169122848	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aacagggataaaatttacttGatttgtcaaatagtccgggt	9	5	1	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr5:169122848G>T	uc003maf.2	+	10	965	c.885G>T	c.(883-885)TTG>TTT	p.L295F	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	295					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAATTTACTTGATTTGTCAAA	0.463													T	169122848	T	T	169122848	3	4	68	1	0	0	0	0	1	0	0	0	4687	1281	45	5	923	5	DOCK2	5	169122848	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08	28900331	169122848	11792412	19	4546											
HCRTR2	3062	broad.mit.edu	37	chr6	55142306	55142306	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgaaataaagcagatccgAgccagaaggaaaacagcccg	11	10	0	3			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr6:55142306A>G	uc003pcl.2	+	5	1206	c.891A>G	c.(889-891)CGA>CGG	p.R297R	HCRTR2_uc010jzv.2_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	297	Cytoplasmic (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGCAGATCCGAGCCAGAAGGA	0.493													G	55142306	G	G	55142306	2	3	68	1	0	0	0	0	0	0	0	1	7002	291	11	4		4	HCRTR2	6	55142306	Silent	SNP	A	TCGA-06-0878-01A-01W-0424-08		55142306	115972761	20	4547											
GHRHR	2692	broad.mit.edu	37	chr7	31016925	31016925	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gttgccatcctctactgcttCctcaaccaagaggtgtgtga	9	12	2	2			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr7:31016925C>T	uc003tbx.2	+	12	1182	c.1134C>T	c.(1132-1134)TTC>TTT	p.F378F	GHRHR_uc003tby.2_Silent_p.F314F|GHRHR_uc003tbz.2_Missense_Mutation_p.P145S	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	378	Helical; Name=7; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	TCTACTGCTTCCTCAACCAAG	0.552													T	31016925	T	T	31016925	2	4	68	1	0	0	0	0	0	0	0	1	6373	854	30	3		3	GHRHR	7	31016925	Silent	SNP	C	TCGA-06-0878-01A-01W-0424-08		31016925	128121738	21	4548											
EGFR	1956	broad.mit.edu	37	chr7	55221781	55221781	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctacaaccccaccacgtaCcagatggatgtgaaccccga	7	16	1	2			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr7:55221781C>T	uc003tqk.2	+	7	1071	c.825C>T	c.(823-825)TAC>TAT	p.Y275Y	EGFR_uc003tqh.2_Silent_p.Y275Y|EGFR_uc003tqi.2_Silent_p.Y275Y|EGFR_uc003tqj.2_Silent_p.Y275Y|EGFR_uc010kzg.1_Silent_p.Y230Y|EGFR_uc011kco.1_Silent_p.Y222Y|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	275	Approximate.|Extracellular (Potential).			Y->A: Strongly reduced autophosphorylation and activation of down-stream kinases; when associated with A-309.	activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCACCACGTACCAGATGGATG	0.587		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221781	T	T	55221781	2	4	68	1	0	0	0	0	0	0	0	1	4967	518	18	3		3	EGFR	7	55221781	Silent	SNP	C	TCGA-06-0878-01A-01W-0424-08	24204856	55221781	103916882	22	4549			1	15		3	3	41	N	GC_C	2.929978e-09
EGFR	1956	broad.mit.edu	37	chr7	55221796	55221796	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgtaccagatggatgtgaaCcccgagggcaaatacagctt	11	10	0	2			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr7:55221796C>T	uc003tqk.2	+	7	1086	c.840C>T	c.(838-840)AAC>AAT	p.N280N	EGFR_uc003tqh.2_Silent_p.N280N|EGFR_uc003tqi.2_Silent_p.N280N|EGFR_uc003tqj.2_Silent_p.N280N|EGFR_uc010kzg.1_Silent_p.N235N|EGFR_uc011kco.1_Silent_p.N227N|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	280	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGGATGTGAACCCCGAGGGCA	0.587		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221796	T	T	55221796	2	4	68	1	0	0	0	0	0	0	0	1	4967	506	18	3		3	EGFR	7	55221796	Silent	SNP	C	TCGA-06-0878-01A-01W-0424-08	15	55221796	103916867	23	4550			1	15		3	3	41	N	GC_C	2.929978e-09
EGFR	1956	broad.mit.edu	37	chr7	55221821	55221822	+	Missense_Mutation	DNP	GC	AT	AT													agggcaaatacagctttggtGccacctgcgtgaagaagtgt					rs149840192		TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr7:55221821_55221822GC>AT	uc003tqk.2	+	7	1111_1112	c.865_866GC>AT	c.(865-867)GCC>ATC	p.A289I	EGFR_uc003tqh.2_Missense_Mutation_p.A289I|EGFR_uc003tqi.2_Missense_Mutation_p.A289I|EGFR_uc003tqj.2_Missense_Mutation_p.A289I|EGFR_uc010kzg.1_Missense_Mutation_p.A244I|EGFR_uc011kco.1_Missense_Mutation_p.A236I|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTTTGGTGCCACCTGCGTG	0.589		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			AT	55221822	AT	AT	55221821	3	1	68	1	0	0	0	0	1	0	0	0	4967	1319	46	3	891	3	EGFR	7	55221821	Missense_Mutation	DNP	GC	TCGA-06-0878-01A-01W-0424-08	25	55221821	103916842	24	4551			1	15		3	3	41	N	GC_C	2.929978e-09
SEMA3E	9723	broad.mit.edu	37	chr7	82997221	82997221	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctcctcttccactacctccAaggtgattttacggaccgta	6	14	2	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr7:82997221A>C	uc003uhy.1	-	17	2475	c.2009T>G	c.(2008-2010)TTG>TGG	p.L670W		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	670					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				CACTACCTCCAAGGTGATTTT	0.468													C	82997221	C	C	82997221	3	2	68	1	0	0	0	0	1	0	0	0	14028	131	5	5	322	5	SEMA3E	7	82997221	Missense_Mutation	SNP	A	TCGA-06-0878-01A-01W-0424-08	27775400	82997221	76141442	25	4552											
ZAN	7455	broad.mit.edu	37	chr7	100350611	100350611	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcaccatccccacagaaaaAcccaccatctccacggaaaa	3	18	2	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr7:100350611A>G	uc003uwj.2	+	14	3048	c.2883A>G	c.(2881-2883)AAA>AAG	p.K961K	ZAN_uc003uwk.2_Silent_p.K961K|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	961	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCACAGAAAAACCCACCATCT	0.512													G	100350611	G	G	100350611	2	3	68	1	0	0	0	0	0	0	0	1	17510	40	2	4		4	ZAN	7	100350611	Silent	SNP	A	TCGA-06-0878-01A-01W-0424-08	17353390	100350611	58788052	26	4553											
LAMB4	22798	broad.mit.edu	37	chr7	107706946	107706946	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaagtagcctgccaggcagCgatcacagcggcggccagac	13	14	1	1	rs148837121		TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr7:107706946C>T	uc010ljo.1	-	20	2630	c.2546G>A	c.(2545-2547)CGC>CAC	p.R849H	LAMB4_uc003vey.2_Missense_Mutation_p.R849H|LAMB4_uc010ljp.1_5'Flank	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	849	Laminin EGF-like 7.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGCCAGGCAGCGATCACAGCG	0.532													T	107706946	T	T	107706946	3	4	68	1	0	0	0	0	1	0	0	0	8613	768	27	1	2799	1	LAMB4	7	107706946	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08	7356335	107706946	51431717	27	4554											
MLL3	58508	broad.mit.edu	37	chr7	151892993	151892993	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaacagtattcatatataccTgaatgatcaactgattttgc	5	7	2	3			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr7:151892993T>C	uc003wla.2	-	28	4596	c.4377A>G	c.(4375-4377)TCA>TCG	p.S1459S	MLL3_uc003wkz.2_Silent_p.S520S	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1459					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CATATATACCTGAATGATCAA	0.363			N		medulloblastoma								C	151892993	C	C	151892993	2	2	68	1	0	0	0	0	0	0	0	1	9622	1594	55	4		4	MLL3	7	151892993	Silent	SNP	T	TCGA-06-0878-01A-01W-0424-08	44186047	151892993	7245670	28	4555											
PREX2	80243	broad.mit.edu	37	chr8	69104577	69104577	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttttttctgcagctaatgaGgcctctcaacgctttggatg	9	9	2	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr8:69104577G>A	uc003xxv.1	+	37	4448	c.4421G>A	c.(4420-4422)AGG>AAG	p.R1474K		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1474					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CAGCTAATGAGGCCTCTCAAC	0.413													A	69104577	A	A	69104577	3	1	68	1	0	0	0	0	1	0	0	0	12477	1000	35	3	4796	3	PREX2	8	69104577	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08		69104577	77259445	29	4556											
LPAR1	1902	broad.mit.edu	37	chr9	113704320	113704320	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aacatgatgaagatacaaacAgtgattccaagtcccatcac	6	10	1	4			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr9:113704320A>C	uc004bfa.2	-	4	429	c.174T>G	c.(172-174)ACT>ACG	p.T58T	LPAR1_uc011lwm.1_Silent_p.T59T|LPAR1_uc004bfb.2_Silent_p.T58T|LPAR1_uc004bfc.2_Silent_p.T58T|LPAR1_uc011lwn.1_Silent_p.T40T|LPAR1_uc011lwo.1_Silent_p.T59T|LPAR1_uc010mub.2_Silent_p.T58T	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	58	Helical; Name=1; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						AGATACAAACAGTGATTCCAA	0.438													C	113704320	C	C	113704320	2	2	68	1	0	0	0	0	0	0	0	1	8904	175	7	5		5	LPAR1	9	113704320	Silent	SNP	A	TCGA-06-0878-01A-01W-0424-08		113704320	27509111	30	4557											
TRAF1	7185	broad.mit.edu	37	chr9	123675735	123675735	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttctcaaacacacgcagcttCccctccagctcagccagaag	6	17	2	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr9:123675735C>T	uc004bku.1	-	5	1148	c.576G>A	c.(574-576)GGG>GGA	p.G192G	TRAF1_uc011lyg.1_Silent_p.G70G|TRAF1_uc010mvl.1_Silent_p.G192G	NM_005658	NP_005649	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	192					apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			skin(2)|ovary(1)	3						CACGCAGCTTCCCCTCCAGCT	0.612													T	123675735	T	T	123675735	2	4	68	1	0	0	0	0	0	0	0	1	16434	842	30	3		3	TRAF1	9	123675735	Silent	SNP	C	TCGA-06-0878-01A-01W-0424-08	9971415	123675735	17537696	31	4558											
GOLGA1	2800	broad.mit.edu	37	chr9	127670739	127670739	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtatcctccaaattctgctCagcaagtgttttctgtaagt	8	9	3	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr9:127670739C>T	uc004bpc.2	-	12	1324	c.982G>A	c.(982-984)GAG>AAG	p.E328K	GOLGA1_uc010mws.2_RNA	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	328	Potential.					Golgi cisterna membrane				ovary(1)	1						AAATTCTGCTCAGCAAGTGTT	0.343													T	127670739	T	T	127670739	3	4	68	1	0	0	0	0	1	0	0	0	6551	835	29	3	1369	3	GOLGA1	9	127670739	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08	3995004	127670739	13542692	32	4559											
KCNT1	57582	broad.mit.edu	37	chr9	138667205	138667205	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctacatcggcagctccccaAccctgtgccacctcctgcct	6	21	0	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr9:138667205A>C	uc011mdq.1	+	20	2367	c.2293A>C	c.(2293-2295)ACC>CCC	p.T765P	KCNT1_uc011mdr.1_Missense_Mutation_p.T592P|KCNT1_uc010nbf.2_Missense_Mutation_p.T720P|KCNT1_uc004cgo.1_Missense_Mutation_p.T514P	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	765						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CAGCTCCCCAACCCTGTGCCA	0.662													C	138667205	C	C	138667205	3	2	68	1	0	0	0	0	1	0	0	0	8091	43	2	5	2371	5	KCNT1	9	138667205	Missense_Mutation	SNP	A	TCGA-06-0878-01A-01W-0424-08	10996466	138667205	2546226	33	4560											
COL17A1	1308	broad.mit.edu	37	chr10	105823552	105823552	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaaagtgggtgagcaggacGccatgttgtttggaactccg	15	8	0	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr10:105823552G>A	uc001kxr.2	-	11	960	c.791C>T	c.(790-792)GCG>GTG	p.A264V	COL17A1_uc010qqv.1_Missense_Mutation_p.A248V|COL17A1_uc009xxp.1_Missense_Mutation_p.A264V	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	264	Cytoplasmic (Potential).|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGAGCAGGACGCCATGTTGTT	0.517													A	105823552	A	A	105823552	3	1	68	1	0	0	0	0	1	0	0	0	3674	1087	38	1	3886	1	COL17A1	10	105823552	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08		105823552	29711195	34	4561											
OR8H2	390151	broad.mit.edu	37	chr11	55873034	55873034	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgcatttctacgactcaaaCgtaattcatcactttttctg	4	10	5	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr11:55873034C>T	uc010riy.1	+	1	516	c.516C>T	c.(514-516)AAC>AAT	p.N172N		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					ACGACTCAAACGTAATTCATC	0.428										HNSCC(53;0.14)			T	55873034	T	T	55873034	2	4	68	1	0	0	0	0	0	0	0	1	11238	535	19	1		1	OR8H2	11	55873034	Silent	SNP	C	TCGA-06-0878-01A-01W-0424-08		55873034	79133482	35	4562											
SUV420H1	51111	broad.mit.edu	37	chr11	67941367	67941370	+	Frame_Shift_Del	DEL	AAAT	-	-													tgtcagttgcaaacattcgcAaataaataaatacctaaaac							TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr11:67941367_67941370delAAAT	uc001onm.1	-	6	810_813	c.554_557delATTT	c.(553-558)TATTTGfs	p.Y185fs	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_Frame_Shift_Del_p.Y13fs|SUV420H1_uc009ysf.2_5'UTR|SUV420H1_uc001ono.1_Frame_Shift_Del_p.Y185fs|SUV420H1_uc001onp.2_Frame_Shift_Del_p.Y185fs|SUV420H1_uc010rqa.1_Frame_Shift_Del_p.Y162fs|SUV420H1_uc001onq.2_Frame_Shift_Del_p.Y185fs	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	185_186					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						AAACATTCGCAAATAAATAAATAC	0.319													-	67941370	-	-	67941367	7	5	68	1	0	1	0	1	0	0	0	0	15411	131	5	0	2132	0	SUV420H1	11	67941367	Frame_Shift_Del	DEL	AAAT	TCGA-06-0878-01A-01W-0424-08	12068333	67941367	67065149	36	4563											
ADAMTS20	80070	broad.mit.edu	37	chr12	43770043	43770043	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	actgttttcataatacctttAttattcttcccttaatgtta	2	8	2	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr12:43770043A>T	uc010skx.1	-	34	5216	c.5216T>A	c.(5215-5217)ATA>AAA	p.I1739K		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1739	GON.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TAATACCTTTATTATTCTTCC	0.274													T	43770043	T	T	43770043	3	4	68	1	0	0	0	0	1	0	0	0	266	449	16	5	539	5	ADAMTS20	12	43770043	Missense_Mutation	SNP	A	TCGA-06-0878-01A-01W-0424-08		43770043	90081852	37	4564											
NCKAP1L	3071	broad.mit.edu	37	chr12	54913072	54913072	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactcccgaatgctggactcCgtagaaaaattgctggtgga	11	10	0	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr12:54913072C>T	uc001sgc.3	+	16	1660	c.1581C>T	c.(1579-1581)TCC>TCT	p.S527S	NCKAP1L_uc010sox.1_Silent_p.S69S|NCKAP1L_uc010soy.1_Silent_p.S477S	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	527					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TGCTGGACTCCGTAGAAAAAT	0.438													T	54913072	T	T	54913072	2	4	68	1	0	0	0	0	0	0	0	1	10222	639	23	2		2	NCKAP1L	12	54913072	Silent	SNP	C	TCGA-06-0878-01A-01W-0424-08	11143029	54913072	78938823	38	4565											
PPFIA2	8499	broad.mit.edu	37	chr12	81688794	81688794	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcaggctgccacgtaccaCgcaggcattcccaaccaaag	10	16	0	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr12:81688794C>T	uc001szo.1	-	24	2906	c.2745G>A	c.(2743-2745)GCG>GCA	p.A915A	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	841										ovary(3)|lung(2)|pancreas(1)	6						CCACGTACCACGCAGGCATTC	0.353													T	81688794	T	T	81688794	2	4	68	1	0	0	0	0	0	0	0	1	12310	523	19	1		1	PPFIA2	12	81688794	Silent	SNP	C	TCGA-06-0878-01A-01W-0424-08	26775722	81688794	52163101	39	4566											
MYO1H	283446	broad.mit.edu	37	chr12	109843786	109843786	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacattggttttgaagaagaCgaccaaggctgtgccactat	10	8	0	3			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr12:109843786C>T	uc010sxn.1	+	7	861	c.861C>T	c.(859-861)GAC>GAT	p.D287D		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						TTGAAGAAGACGACCAAGGCT	0.498													T	109843786	T	T	109843786	2	4	68	1	0	0	0	0	0	0	0	1	10075	535	19	1		1	MYO1H	12	109843786	Silent	SNP	C	TCGA-06-0878-01A-01W-0424-08	28154992	109843786	24008109	40	4567											
C12orf51	283450	broad.mit.edu	37	chr12	112703783	112703783	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgggagagtccactgtttctCtctcctaacacagaagaaag	9	10	2	3			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr12:112703783C>T	uc009zwc.2	-	8	1119	c.1101G>A	c.(1099-1101)GAG>GAA	p.E367E	C12orf51_uc010syk.1_Silent_p.E190E|C12orf51_uc001tts.2_Silent_p.E190E|C12orf51_uc001ttt.3_Silent_p.E190E	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CACTGTTTCTCTCTCCTAACA	0.418													T	112703783	T	T	112703783	2	4	68	1	0	0	0	0	0	0	0	1	1696	912	32	3		3	C12orf51	12	112703783	Silent	SNP	C	TCGA-06-0878-01A-01W-0424-08	2859997	112703783	21148112	41	4568											
ATP8B4	79895	broad.mit.edu	37	chr15	50254197	50254197	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agttatttctgtcttctgatCcaggtcatcatgtacttcac	6	10	6	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr15:50254197C>A	uc001zxu.2	-	14	1406	c.1264G>T	c.(1264-1266)GAT>TAT	p.D422Y	ATP8B4_uc010ber.2_Missense_Mutation_p.D295Y|ATP8B4_uc010ufd.1_Missense_Mutation_p.D295Y|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	422	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GTCTTCTGATCCAGGTCATCA	0.264													A	50254197	A	A	50254197	3	1	68	1	0	0	0	0	1	0	0	0	1197	855	30	5	2374	5	ATP8B4	15	50254197	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08		50254197	52277195	42	4569											
ITFG3	83986	broad.mit.edu	37	chr16	315011	315012	+	Frame_Shift_Del	DEL	GT	-	-													ctcccggctgcggtaccagaGtgaggcgtagaggcacgcca							TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr16:315011_315012delGT	uc002cgf.2	+	13	1844_1845	c.1649_1650delGT	c.(1648-1650)AGTfs	p.S550fs	ITFG3_uc002cgg.2_Intron|ITFG3_uc010uud.1_Intron|ITFG3_uc002cgh.2_Frame_Shift_Del_p.S550fs	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	550	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				CGGTACCAGAGTGAGGCGTAGA	0.649													-	315012	-	-	315011	7	5	68	1	0	1	0	1	0	0	0	0	7871	1029	36	0	1691	0	ITFG3	16	315011	Frame_Shift_Del	DEL	GT	TCGA-06-0878-01A-01W-0424-08		315011	90039742	43	4570											
UMOD	7369	broad.mit.edu	37	chr16	20357449	20357449	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccactggccaggacgtaccGtcaacactgtcccacagggg	11	16	1	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr16:20357449G>A	uc002dgz.2	-	5	1310	c.1181C>T	c.(1180-1182)ACG>ATG	p.T394M	UMOD_uc002dha.2_Missense_Mutation_p.T394M|UMOD_uc002dhb.2_Missense_Mutation_p.T427M	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	394	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						AGGACGTACCGTCAACACTGT	0.398													A	20357449	A	A	20357449	3	1	68	1	0	0	0	0	1	0	0	0	16976	1159	40	1	769	1	UMOD	16	20357449	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08	20042438	20357449	69997304	44	4571											
NOD2	64127	broad.mit.edu	37	chr16	50731207	50731209	+	In_Frame_Del	DEL	TCC	-	-													tgaggaggaaagagcaagtgTcctcctcggacattctccgg							TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr16:50731207_50731209delTCC	uc002egm.1	+	1	158_160	c.53_55delTCC	c.(52-57)GTCCTC>GTC	p.L20del	NOD2_uc010cbj.1_Intron|NOD2_uc010cbk.1_Intron|NOD2_uc002egl.1_5'UTR	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	20					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				AGAGCAAGTGTCCTCCTCGGACA	0.601													-	50731209	-	-	50731207	7	5	68	1	0	1	0	1	0	0	0	0	10517	1667	58	0	55	0	NOD2	16	50731207	In_Frame_Del	DEL	TCC	TCGA-06-0878-01A-01W-0424-08	30373758	50731207	39623546	45	4572											
ATP2C2	9914	broad.mit.edu	37	chr16	84472802	84472802	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggccattccagagggtctGcccatcgtcgtcatggtgac	13	13	2	2			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr16:84472802G>A	uc002fhx.2	+	12	1106	c.1017G>A	c.(1015-1017)CTG>CTA	p.L339L	ATP2C2_uc010chj.2_Silent_p.L339L|ATP2C2_uc002fhy.2_Silent_p.L356L|ATP2C2_uc002fhz.2_Silent_p.L188L	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	339	Helical; Name=5; (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						CAGAGGGTCTGCCCATCGTCG	0.572													A	84472802	A	A	84472802	2	1	68	1	0	0	0	0	0	0	0	1	1144	1306	46	3		3	ATP2C2	16	84472802	Silent	SNP	G	TCGA-06-0878-01A-01W-0424-08	33741595	84472802	5881951	46	4573											
FCGBP	8857	broad.mit.edu	37	chr19	40395919	40395919	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacgttctcctgcaggacgGcaaaccgatgtaggccaggc	12	14	1	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr19:40395919G>A	uc002omp.3	-	15	7486	c.7478C>T	c.(7477-7479)GCC>GTC	p.A2493V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2493	VWFD 6.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTGCAGGACGGCAAACCGATG	0.627													A	40395919	A	A	40395919	3	1	68	1	0	0	0	0	1	0	0	0	5778	1203	42	3	8827	3	FCGBP	19	40395919	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08		40395919	18733064	47	4574											
RAB4B	53916	broad.mit.edu	37	chr19	41292794	41292794	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggctctggcattcagtacGgggatgcgtccctccgccag	14	13	2	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr19:41292794G>A	uc002opd.1	+	7	678	c.568G>A	c.(568-570)GGG>AGG	p.G190R	RAB4B_uc002opc.1_RNA|RAB4B_uc002ope.1_RNA|EGLN2_uc010ehd.2_5'UTR|RAB4B_uc002opf.1_Missense_Mutation_p.G216R	NM_016154	NP_057238	P61018	RAB4B_HUMAN	ras-related GTP-binding protein 4b	190					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	intracellular|plasma membrane	GTP binding|GTPase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CATTCAGTACGGGGATGCGTC	0.682													A	41292794	A	A	41292794	3	1	68	1	0	0	0	0	1	0	0	0	12947	1116	39	2	594	2	RAB4B	19	41292794	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08	896875	41292794	17836189	48	4575											
AXL	558	broad.mit.edu	37	chr19	41726597	41726597	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagggaatatcacaggtgccCggggactcacgggcaccctt	13	13	2	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr19:41726597C>T	uc010ehj.2	+	2	332	c.142C>T	c.(142-144)CGG>TGG	p.R48W	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Missense_Mutation_p.R48W|AXL_uc010ehk.2_Missense_Mutation_p.R48W	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	48	Extracellular (Potential).|Interaction with GAS6.|Ig-like C2-type 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						CACAGGTGCCCGGGGACTCAC	0.622													T	41726597	T	T	41726597	3	4	68	1	0	0	0	0	1	0	0	0	1238	643	23	2	148	2	AXL	19	41726597	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08	433803	41726597	17402386	49	4576											
ERCC1	2067	broad.mit.edu	37	chr19	45912970	45912970	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agggctcgtgcaggacatcaAacagcctccgggcctggatg	14	12	1	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr19:45912970A>G	uc002pbs.1	-	10	1003	c.857T>C	c.(856-858)TTT>TCT	p.F286S	CD3EAP_uc002pbq.1_3'UTR|CD3EAP_uc002pbr.1_3'UTR|ERCC1_uc002pbt.1_Missense_Mutation_p.F262S|ERCC1_uc002pbu.1_Missense_Mutation_p.F214S	NM_001983	NP_001974	P07992	ERCC1_HUMAN	excision repair cross-complementing 1 isofrom 2	286					mitotic recombination|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to oxidative stress|transcription-coupled nucleotide-excision repair	cytoplasm|nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair complex	damaged DNA binding|endonuclease activity|protein C-terminus binding|protein domain specific binding|single-stranded DNA binding			ovary(2)	2		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0247)		CAGGACATCAAACAGCCTCCG	0.502								NER					G	45912970	G	G	45912970	3	3	68	1	0	0	0	0	1	0	0	0	5212	14	1	4	40	4	ERCC1	19	45912970	Missense_Mutation	SNP	A	TCGA-06-0878-01A-01W-0424-08	4186373	45912970	13216013	50	4577											
NCR1	9437	broad.mit.edu	37	chr19	55420770	55420770	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tacgggaaggtccaggcggaGttccccctgggccctgtgac	15	13	0	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr19:55420770G>C	uc002qib.2	+	4	560	c.522G>C	c.(520-522)GAG>GAC	p.E174D	NCR1_uc002qic.2_Missense_Mutation_p.E174D|NCR1_uc002qie.2_Missense_Mutation_p.E174D|NCR1_uc002qid.2_Missense_Mutation_p.E79D|NCR1_uc002qif.2_Missense_Mutation_p.E79D|NCR1_uc010esj.2_Missense_Mutation_p.E67D	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	174	Extracellular (Potential).|Ig-like 2.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TCCAGGCGGAGTTCCCCCTGG	0.572													C	55420770	C	C	55420770	3	2	68	1	0	0	0	0	1	0	0	0	10237	1020	36	5	536	5	NCR1	19	55420770	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08	9507800	55420770	3708213	51	4578											
CHGB	1114	broad.mit.edu	37	chr20	5903131	5903131	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggggaggaggacatccaagGcccaacaaaggcagacacag	14	10	0	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr20:5903131G>A	uc002wmg.2	+	4	647	c.341G>A	c.(340-342)GGC>GAC	p.G114D	CHGB_uc010zqz.1_Intron	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	114						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GACATCCAAGGCCCAACAAAG	0.607													A	5903131	A	A	5903131	3	1	68	1	0	0	0	0	1	0	0	0	3339	1203	42	3	355	3	CHGB	20	5903131	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08		5903131	57122389	52	4579											
LSM14B	149986	broad.mit.edu	37	chr20	60697790	60697790	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catctccaaggcgcagatccGctacgagggcattctctaca	9	14	2	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr20:60697790G>A	uc010gjy.1	+	1	274	c.68G>A	c.(67-69)CGC>CAC	p.R23H	LSM14B_uc002ybt.2_Missense_Mutation_p.R23H|LSM14B_uc010gjx.1_Missense_Mutation_p.R23H|LSM14B_uc002ybv.2_Missense_Mutation_p.R23H|LSM14B_uc010gjz.1_5'Flank|LSM14B_uc010zzz.1_5'Flank	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	23					multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			GCGCAGATCCGCTACGAGGGC	0.706													A	60697790	A	A	60697790	3	1	68	1	0	0	0	0	1	0	0	0	9055	1087	38	1	70	1	LSM14B	20	60697790	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08	54794659	60697790	2327730	53	4580											
KRTAP19-1	337882	broad.mit.edu	37	chr21	31852408	31852408	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctccattgtacgatgggcGgcagcagccatatccatagc	10	13	0	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr21:31852408G>A	uc011acx.1	-	1	229	c.229C>T	c.(229-231)CGC>TGC	p.R77C		NM_181607	NP_853638	Q8IUB9	KR191_HUMAN	keratin associated protein 19-1	77	26 X 2 AA repeats of G-[YCGS].					intermediate filament					0						TACGATGGGCGGCAGCAGCCA	0.488													A	31852408	A	A	31852408	3	1	68	1	0	0	0	0	1	0	0	0	8528	1116	39	2	45	2	KRTAP19-1	21	31852408	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08		31852408	16277487	54	4581											
KRTAP20-2	337976	broad.mit.edu	37	chr21	32007726	32007726	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggctatggtggctatggataTggctgctgccgcccatcttg	14	10	1	0			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr21:32007726T>A	uc011adg.1	+	1	144	c.144T>A	c.(142-144)TAT>TAA	p.Y48*		NM_181616	NP_853647	Q3LI61	KR202_HUMAN	keratin associated protein 20-2	48						intermediate filament				central_nervous_system(1)	1						GCTATGGATATGGCTGCTGCC	0.557													A	32007726	A	A	32007726	4	1	68	1	0	0	0	0	0	1	0	0	8537	1471	51	5	146	5	KRTAP20-2	21	32007726	Nonsense_Mutation	SNP	T	TCGA-06-0878-01A-01W-0424-08	155318	32007726	16122169	55	4582											
BCL2L13	23786	broad.mit.edu	37	chr22	18178948	18178948	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgggaatgtacactggagaCcacagttcatgccagcggct	12	11	1	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr22:18178948C>T	uc002zmw.2	+	5	646	c.428C>T	c.(427-429)ACC>ATC	p.T143I	BCL2L13_uc002zmu.2_Missense_Mutation_p.T143I|BCL2L13_uc002zmv.2_Missense_Mutation_p.T143I|BCL2L13_uc002zmx.2_5'UTR|BCL2L13_uc002zmy.2_Intron|BCL2L13_uc010gqy.2_Intron|BCL2L13_uc011agk.1_Intron|BCL2L13_uc010gqz.2_Intron|BCL2L13_uc002zmz.2_Intron	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	143					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		ACACTGGAGACCACAGTTCAT	0.383													T	18178948	T	T	18178948	3	4	68	1	0	0	0	0	1	0	0	0	1371	507	18	3	442	3	BCL2L13	22	18178948	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08		18178948	33125618	56	4583											
TMPRSS6	164656	broad.mit.edu	37	chr22	37482392	37482392	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcaggcccttcttccagaCgaccgccatgatggcccccg	11	17	1	2			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr22:37482392C>T	uc003aqs.1	-	8	1045	c.931G>A	c.(931-933)GTC>ATC	p.V311I	TMPRSS6_uc003aqt.1_Missense_Mutation_p.V302I|TMPRSS6_uc003aqu.2_Missense_Mutation_p.V302I	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	311	CUB 1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						TTCTTCCAGACGACCGCCATG	0.667													T	37482392	T	T	37482392	3	4	68	1	0	0	0	0	1	0	0	0	16248	536	19	1	1548	1	TMPRSS6	22	37482392	Missense_Mutation	SNP	C	TCGA-06-0878-01A-01W-0424-08	19303444	37482392	13822174	57	4584											
TBC1D22A	25771	broad.mit.edu	37	chr22	47189513	47189513	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggacgctggggaggacgacGatgagctcctggccatggcg	19	10	0	1			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chr22:47189513G>A	uc003bib.2	+	3	370	c.235G>A	c.(235-237)GAT>AAT	p.D79N	TBC1D22A_uc010haf.2_Missense_Mutation_p.D49N|TBC1D22A_uc003bic.2_Missense_Mutation_p.D79N|TBC1D22A_uc003bie.2_Missense_Mutation_p.D60N|TBC1D22A_uc003bid.2_RNA|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Missense_Mutation_p.D32N	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	79						intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		GGAGGACGACGATGAGCTCCT	0.647													A	47189513	A	A	47189513	3	1	68	1	0	0	0	0	1	0	0	0	15608	1058	37	2	245	2	TBC1D22A	22	47189513	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08	9707121	47189513	4115053	58	4585											
SCML2	10389	broad.mit.edu	37	chrX	18275064	18275064	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttatcacactgcagactgtGgcagaagttctcaagaaagc	10	9	2	3			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chrX:18275064G>A	uc004cyl.2	-	11	1517	c.1360C>T	c.(1360-1362)CAC>TAC	p.H454Y	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.H454Y|SCML2_uc011miz.1_Missense_Mutation_p.H388Y|SCML2_uc010nfc.2_Missense_Mutation_p.H190Y	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	454					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					TGCAGACTGTGGCAGAAGTTC	0.468													A	18275064	A	A	18275064	3	1	68	1	0	0	0	0	1	0	0	0	13910	1348	47	3	762	3	SCML2	23	18275064	Missense_Mutation	SNP	G	TCGA-06-0878-01A-01W-0424-08		18275064	136995496	59	4586											
KLHL13	90293	broad.mit.edu	37	chrX	117054239	117054239	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agtaatcactagcagatgccAtcatgactctatgcacaggg	9	10	3	2			TCGA-06-0878-01A-01W-0424-08	TCGA-06-0878-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	07869e29-9ced-4be5-9a6c-8fd3c29ae487	054e6a05-b5f5-4c0f-bd7d-72a04819a7ab	g.chrX:117054239A>T	uc004eql.2	-	3	397	c.335T>A	c.(334-336)ATG>AAG	p.M112K	KLHL13_uc004eqk.2_Missense_Mutation_p.M61K|KLHL13_uc011mtn.1_5'UTR|KLHL13_uc011mto.1_Missense_Mutation_p.M106K|KLHL13_uc011mtp.1_Missense_Mutation_p.M114K|KLHL13_uc004eqm.2_Missense_Mutation_p.M61K|KLHL13_uc011mtq.1_Missense_Mutation_p.M96K	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	112	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						AGCAGATGCCATCATGACTCT	0.408													T	117054239	T	T	117054239	3	4	68	1	0	0	0	0	1	0	0	0	8369	217	8	5	1652	5	KLHL13	23	117054239	Missense_Mutation	SNP	A	TCGA-06-0878-01A-01W-0424-08	98779175	117054239	38216321	60	4587											
SMPDL3B	27293	broad.mit.edu	37	chr1	28285085	28285085	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgaggcctatggggtgccGgacgccagcgcccactccat	13	16	0	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr1:28285085G>A	uc001bpg.2	+	8	1295	c.1104G>A	c.(1102-1104)CCG>CCA	p.P368P	SMPDL3B_uc010ofq.1_Silent_p.P162P|SMPDL3B_uc010ofr.1_Silent_p.P320P|XKR8_uc001bph.1_5'Flank	NM_014474	NP_055289	Q92485	ASM3B_HUMAN	acid sphingomyelinase-like phosphodiesterase 3B	368					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			ovary(3)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		ATGGGGTGCCGGACGCCAGCG	0.617													A	28285085	A	A	28285085	2	1	69	1	0	0	0	0	0	0	0	1	14809	1103	39	2		2	SMPDL3B	1	28285085	Silent	SNP	G	TCGA-06-0879-01A-01W-0424-08		28285085	220965536	1	4588											
BRDT	676	broad.mit.edu	37	chr1	92479806	92479806	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccttcaaagtgacattatgaCaatgtttgaaaacaactttg	6	7	1	3			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr1:92479806C>A	uc001dok.3	+	19	3168	c.2819C>A	c.(2818-2820)ACA>AAA	p.T940K	BRDT_uc001dol.3_Missense_Mutation_p.T940K|BRDT_uc010osz.1_Missense_Mutation_p.T944K|BRDT_uc009wdf.2_Missense_Mutation_p.T867K|BRDT_uc010ota.1_Missense_Mutation_p.T894K|BRDT_uc010otb.1_Missense_Mutation_p.T894K|BRDT_uc001dom.3_Missense_Mutation_p.T940K	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	940					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GACATTATGACAATGTTTGAA	0.269													A	92479806	A	A	92479806	3	1	69	1	0	0	0	0	1	0	0	0	1508	478	17	5	2889	5	BRDT	1	92479806	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	64194721	92479806	156770815	2	4589											
COL11A1	1301	broad.mit.edu	37	chr1	103345386	103345386	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgatgacagtggtaggtgaaAttttgccgagcagaggcagt	15	5	0	4			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr1:103345386A>G	uc001dul.2	-	66	5445	c.5127T>C	c.(5125-5127)AAT>AAC	p.N1709N	COL11A1_uc001duk.2_Silent_p.N905N|COL11A1_uc001dum.2_Silent_p.N1721N|COL11A1_uc001dun.2_Silent_p.N1670N|COL11A1_uc009weh.2_Silent_p.N1593N	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1709	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGTAGGTGAAATTTTGCCGAG	0.423													G	103345386	G	G	103345386	2	3	69	1	0	0	0	0	0	0	0	1	3667	98	4	4		4	COL11A1	1	103345386	Silent	SNP	A	TCGA-06-0879-01A-01W-0424-08	10865580	103345386	145905235	3	4590											
SLC6A17	388662	broad.mit.edu	37	chr1	110740739	110740739	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttccccaactgggccatggcActcctgatcaccctcatcgt	7	17	2	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr1:110740739A>G	uc009wfq.2	+	12	2318	c.1857A>G	c.(1855-1857)GCA>GCG	p.A619A		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	619	Helical; Name=12; (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GGGCCATGGCACTCCTGATCA	0.657													G	110740739	G	G	110740739	2	3	69	1	0	0	0	0	0	0	0	1	14680	146	6	4		4	SLC6A17	1	110740739	Silent	SNP	A	TCGA-06-0879-01A-01W-0424-08	7395353	110740739	138509882	4	4591											
NCF2	4688	broad.mit.edu	37	chr1	183542320	183542320	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctgagcaatcccacctacCgtcgccttgcctaggtaatc	8	15	0	1	rs147657171		TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr1:183542320C>T	uc001gqj.3	-	5	884	c.609G>A	c.(607-609)ACG>ACA	p.T203T	NCF2_uc010pod.1_Silent_p.T158T|NCF2_uc010poe.1_Intron|NCF2_uc001gqk.3_Silent_p.T203T	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	203					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						TCCCACCTACCGTCGCCTTGC	0.572													T	183542320	T	T	183542320	2	4	69	1	0	0	0	0	0	0	0	1	10217	666	23	2		2	NCF2	1	183542320	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08	72801581	183542320	65708301	5	4592											
GALNT2	2590	broad.mit.edu	37	chr1	230314000	230314000	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttgaccccattaaaaagaaaGaccttcatcacagcaatgga	6	10	2	3			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr1:230314000G>C	uc010pwa.1	+	2	235	c.163G>C	c.(163-165)GAC>CAC	p.D55H	GALNT2_uc010pvy.1_Missense_Mutation_p.D17H|GALNT2_uc010pvz.1_Intron	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	55	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				TAAAAAGAAAGACCTTCATCA	0.473													C	230314000	C	C	230314000	3	2	69	1	0	0	0	0	1	0	0	0	6213	942	33	5	169	5	GALNT2	1	230314000	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	46771680	230314000	18936621	6	4593											
LGALS8	3964	broad.mit.edu	37	chr1	236704996	236704996	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctagtctggaactgacagagAtaagtagagaaaatgtaaat	10	4	1	3			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr1:236704996A>G	uc001hxz.1	+	7	889	c.508A>G	c.(508-510)ATA>GTA	p.I170V	LGALS8_uc001hxw.1_Missense_Mutation_p.I170V|LGALS8_uc001hxy.1_Missense_Mutation_p.I170V|LGALS8_uc009xgg.1_RNA|LGALS8_uc001hya.1_Missense_Mutation_p.I170V|LGALS8_uc001hyb.1_Missense_Mutation_p.I170V|LGALS8_uc001hyc.1_Intron	NM_201543	NP_963837	O00214	LEG8_HUMAN	galectin-8 isoform b	170						cytoplasm|extracellular space	sugar binding			ovary(1)	1	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.0253)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ACTGACAGAGATAAGTAGAGA	0.303													G	236704996	G	G	236704996	3	3	69	1	0	0	0	0	1	0	0	0	8747	333	12	4	526	4	LGALS8	1	236704996	Missense_Mutation	SNP	A	TCGA-06-0879-01A-01W-0424-08	6390996	236704996	12545625	7	4594											
VN1R5	317705	broad.mit.edu	37	chr1	247419512	247419512	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctggttttattaccatataaAtcttcttttatccacaagcc	3	10	2	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr1:247419512A>G	uc010pyu.1	+	2	139	c.139A>G	c.(139-141)ATC>GTC	p.I47V		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	47	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			TACCATATAAATCTTCTTTTA	0.353													G	247419512	G	G	247419512	3	3	69	1	0	0	0	0	1	0	0	0	17178	101	4	4	141	4	VN1R5	1	247419512	Missense_Mutation	SNP	A	TCGA-06-0879-01A-01W-0424-08	10714516	247419512	1831109	8	4595											
FAM136A	84908	broad.mit.edu	37	chr2	70524589	70524589	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctttgtcgttgcaatgcatGgtgcaccgggccaggcggtc	15	11	0	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr2:70524589G>A	uc002sgq.3	-	3	326	c.249C>T	c.(247-249)ACC>ACT	p.T83T	FAM136A_uc010fdp.2_RNA	NM_032822	NP_116211	Q96C01	F136A_HUMAN	hypothetical protein LOC84908	83						mitochondrion	protein binding				0						TGCAATGCATGGTGCACCGGG	0.403													A	70524589	A	A	70524589	2	1	69	1	0	0	0	0	0	0	0	1	5450	1335	47	3		3	FAM136A	2	70524589	Silent	SNP	G	TCGA-06-0879-01A-01W-0424-08		70524589	172674784	9	4596											
TEKT4	150483	broad.mit.edu	37	chr2	95537709	95537709	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagcaacggctggagcgcGccctggacgccacagaggtg	16	12	0	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr2:95537709G>A	uc002stw.1	+	1	478	c.385G>A	c.(385-387)GCC>ACC	p.A129T	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	129	Potential.				cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						GCTGGAGCGCGCCCTGGACGC	0.657													A	95537709	A	A	95537709	3	1	69	1	0	0	0	0	1	0	0	0	15752	1087	38	1	387	1	TEKT4	2	95537709	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	25013120	95537709	147661664	10	4597											
SCN1A	6323	broad.mit.edu	37	chr2	166847871	166847871	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggacatggtcagatcagtttTttctgtaatagagttttcat	9	5	4	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr2:166847871T>A	uc010zcz.1	-	26	5899	c.5881A>T	c.(5881-5883)AAA>TAA	p.K1961*		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1972						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGATCAGTTTTTTCTGTAATA	0.363													A	166847871	A	A	166847871	4	1	69	1	0	0	0	0	0	1	0	0	13914	1850	64	5	119	5	SCN1A	2	166847871	Nonsense_Mutation	SNP	T	TCGA-06-0879-01A-01W-0424-08	71310162	166847871	76351502	11	4598											
OSBPL6	114880	broad.mit.edu	37	chr2	179253861	179253861	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaagcagtgtttgcatttGcaaactcacatttgtcaagg	8	8	2	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr2:179253861G>A	uc002ulx.2	+	21	2660	c.2282G>A	c.(2281-2283)TGC>TAC	p.C761Y	OSBPL6_uc002uly.2_Missense_Mutation_p.C786Y|OSBPL6_uc010zfe.1_Missense_Mutation_p.C730Y|OSBPL6_uc002ulz.2_Missense_Mutation_p.C725Y|OSBPL6_uc002uma.2_Missense_Mutation_p.C765Y	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	761					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			GTTTGCATTTGCAAACTCACA	0.333													A	179253861	A	A	179253861	3	1	69	1	0	0	0	0	1	0	0	0	11281	1319	46	3	2478	3	OSBPL6	2	179253861	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	12405990	179253861	63945512	12	4599											
TTN	7273	broad.mit.edu	37	chr2	179634524	179634524	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agttttccctgcacaactatCttgaacttttcactcatctc	3	13	4	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr2:179634524C>A	uc010zfg.1	-	37	9008	c.8784G>T	c.(8782-8784)AAG>AAT	p.K2928N	TTN_uc010zfh.1_Missense_Mutation_p.K2882N|TTN_uc010zfi.1_Missense_Mutation_p.K2882N|TTN_uc010zfj.1_Missense_Mutation_p.K2882N|TTN_uc002unb.2_Missense_Mutation_p.K2928N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2928							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACAACTATCTTGAACTTTT	0.458													A	179634524	A	A	179634524	3	1	69	1	0	0	0	0	1	0	0	0	16732	912	32	5	102508	5	TTN	2	179634524	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	380663	179634524	63564849	13	4600											
ZSWIM2	151112	broad.mit.edu	37	chr2	187692829	187692829	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	taatttcccccatacagttaCtataccttttagacaaacta	2	11	0	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr2:187692829C>G	uc002upu.1	-	9	1824	c.1784G>C	c.(1783-1785)AGT>ACT	p.S595T		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	595					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			CATACAGTTACTATACCTTTT	0.338													G	187692829	G	G	187692829	3	3	69	1	0	0	0	0	1	0	0	0	18238	565	20	5	121	5	ZSWIM2	2	187692829	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	8058305	187692829	55506544	14	4601											
FAM126B	285172	broad.mit.edu	37	chr2	201846441	201846441	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctttatccttggctgaaCgcccagttgctactttcctt	6	12	1	1	rs138872845		TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr2:201846441C>T	uc002uws.3	-	12	1333	c.1145G>A	c.(1144-1146)CGT>CAT	p.R382H	FAM126B_uc002uwu.2_Missense_Mutation_p.R356H|FAM126B_uc002uwv.2_Missense_Mutation_p.R382H	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	382						intracellular				ovary(1)	1						CTTGGCTGAACGCCCAGTTGC	0.493													T	201846441	T	T	201846441	3	4	69	1	0	0	0	0	1	0	0	0	5430	536	19	1	451	1	FAM126B	2	201846441	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	14153612	201846441	41352932	15	4602											
CHRNG	1146	broad.mit.edu	37	chr2	233405386	233405386	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgctgagggtgccgtccacCatggtgtggcggccggatat	17	10	0	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr2:233405386C>T	uc002vsx.1	+	4	336	c.315C>T	c.(313-315)ACC>ACT	p.T105T	CHRNG_uc010fyd.2_Silent_p.T105T|CHRNG_uc010fye.1_Silent_p.T105T	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	105	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		TGCCGTCCACCATGGTGTGGC	0.652													T	233405386	T	T	233405386	2	4	69	1	0	0	0	0	0	0	0	1	3396	581	21	3		3	CHRNG	2	233405386	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08	31558945	233405386	9793987	16	4603											
ITPR1	3708	broad.mit.edu	37	chr3	4716846	4716846	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttctggccatattggactGtgtacatgtgacaacaatct	8	10	2	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr3:4716846G>A	uc003bqa.2	+	23	3041	c.2693G>A	c.(2692-2694)TGT>TAT	p.C898Y	ITPR1_uc010hca.1_Missense_Mutation_p.C883Y|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.C883Y	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	898	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		ATATTGGACTGTGTACATGTG	0.393													A	4716846	A	A	4716846	3	1	69	1	0	0	0	0	1	0	0	0	7920	1377	48	3	2775	3	ITPR1	3	4716846	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08		4716846	193305584	17	4604											
SRGAP3	9901	broad.mit.edu	37	chr3	9034619	9034619	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccccccaaagccgtaatcCgagatgtgctccgtggggga	12	14	0	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr3:9034619C>T	uc003brf.1	-	20	3205	c.2529G>A	c.(2527-2529)TCG>TCA	p.S843S	SRGAP3_uc003brg.1_Silent_p.S819S	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	843					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		AGCCGTAATCCGAGATGTGCT	0.557			T	RAF1	pilocytic astrocytoma								T	9034619	T	T	9034619	2	4	69	1	0	0	0	0	0	0	0	1	15146	639	23	2		2	SRGAP3	3	9034619	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08	4317773	9034619	188987811	18	4605											
SLC6A6	6533	broad.mit.edu	37	chr3	14509599	14509599	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acatatgtgtaacttagggaCtgtatgctgctgggatgcct	12	7	0	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr3:14509599C>A	uc010heg.2	+	16	1266	c.975C>A	c.(973-975)GAC>GAA	p.D325E	SLC6A6_uc003byq.2_Missense_Mutation_p.D325E|SLC6A6_uc003byr.2_Intron	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	325					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						AACTTAGGGACTGTATGCTGC	0.453											OREG0015421	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	14509599	A	A	14509599	3	1	69	1	0	0	0	0	1	0	0	0	14688	564	20	5	1005	5	SLC6A6	3	14509599	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	5474980	14509599	183512831	19	4606											
ADCY5	111	broad.mit.edu	37	chr3	123003491	123003491	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cctccattgaggaagtaggtCatcatctcgcctttgccctt	8	13	3	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr3:123003491C>A	uc003egh.1	-	21	3750	c.3750G>T	c.(3748-3750)ATG>ATT	p.M1250I	ADCY5_uc003egg.1_Missense_Mutation_p.M908I	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1250	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GGAAGTAGGTCATCATCTCGC	0.607													A	123003491	A	A	123003491	3	1	69	1	0	0	0	0	1	0	0	0	297	826	29	5	39	5	ADCY5	3	123003491	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	108493892	123003491	75018939	20	4607											
ATP2C1	27032	broad.mit.edu	37	chr3	130672707	130672707	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtccagcttgacaggtgagAcaacgccttgttctaaggtg	12	9	1	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr3:130672707A>G	uc003enl.2	+	9	796	c.574A>G	c.(574-576)ACA>GCA	p.T192A	ATP2C1_uc011blg.1_Missense_Mutation_p.T226A|ATP2C1_uc011blh.1_Missense_Mutation_p.T187A|ATP2C1_uc011bli.1_Missense_Mutation_p.T226A|ATP2C1_uc003enk.2_Missense_Mutation_p.T176A|ATP2C1_uc003enm.2_Missense_Mutation_p.T192A|ATP2C1_uc003enn.2_Missense_Mutation_p.T176A|ATP2C1_uc003eno.2_Missense_Mutation_p.T192A|ATP2C1_uc003enp.2_Missense_Mutation_p.T192A|ATP2C1_uc003enq.2_Missense_Mutation_p.T192A|ATP2C1_uc003enr.2_Missense_Mutation_p.T192A|ATP2C1_uc003ens.2_Missense_Mutation_p.T192A|ATP2C1_uc003ent.2_Missense_Mutation_p.T192A	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	192	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	GACAGGTGAGACAACGCCTTG	0.438									Hailey-Hailey_disease				G	130672707	G	G	130672707	3	3	69	1	0	0	0	0	1	0	0	0	1143	275	10	4	604	4	ATP2C1	3	130672707	Missense_Mutation	SNP	A	TCGA-06-0879-01A-01W-0424-08	7669216	130672707	67349723	21	4608											
AADACL2	344752	broad.mit.edu	37	chr3	151475174	151475174	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttacagaatttgccactaaCctatattcttacttgtcaac	4	10	2	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr3:151475174C>T	uc003ezc.2	+	5	1118	c.998C>T	c.(997-999)ACC>ATC	p.T333I	AADACL2_uc010hvn.2_Missense_Mutation_p.T120I	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	333						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TTGCCACTAACCTATATTCTT	0.378													T	151475174	T	T	151475174	3	4	69	1	0	0	0	0	1	0	0	0	11	507	18	3	1016	3	AADACL2	3	151475174	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	20802467	151475174	46547256	22	4609											
PIK3CA	5290	broad.mit.edu	37	chr3	178928081	178928081	+	Missense_Mutation	SNP	A	C	C													ccagtacctcatggattagaAgatttgctgaaccctattgg							TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr3:178928081A>C	uc003fjk.2	+	8	1516	c.1359A>C	c.(1357-1359)GAA>GAC	p.E453D		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	453	C2 PI3K-type.		E -> Q (in cancer; shows an increase in lipid kinase activity; may disrupt the interaction of the C2 PI3K-type domain with the iSH2 region of the p85 regulatory subunit).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E453K(5)|p.E453A(1)|p.P449_L455del(1)|p.G451_L456>V(1)|p.E453del(1)|p.E453Q(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATGGATTAGAAGATTTGCTGA	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			C	178928081	C	C	178928081	3	2	69	1	0	0	0	0	1	0	0	0	11913	69	3	5	1385	5	PIK3CA	3	178928081	Missense_Mutation	SNP	A	TCGA-06-0879-01A-01W-0424-08	27452907	178928081	19094349	23	4610	6	2									
PIK3CA	5290	broad.mit.edu	37	chr3	178928087	178928101	+	In_Frame_Del	DEL	GCTGAACCCTATTGG	-	-													cctcatggattagaagatttGctgaaccctattggtgttac							TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr3:178928087_178928101delGCTGAACCCTATTGG	uc003fjk.2	+	8	1522_1536	c.1365_1379delGCTGAACCCTATTGG	c.(1363-1380)TTGCTGAACCCTATTGGT>TTT	p.455_460LLNPIG>F		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	455_460	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N457K(1)|p.G451_L456>V(1)|p.P449_L455del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TAGAAGATTTGCTGAACCCTATTGGTGTTACTGGA	0.33		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			-	178928101	-	-	178928087	7	5	69	1	0	1	0	1	0	0	0	0	11913	1310	46	0	1391	0	PIK3CA	3	178928087	In_Frame_Del	DEL	GCTGAACCCTATTGG	TCGA-06-0879-01A-01W-0424-08	6	178928087	19094343	24	4611	6	2									
FBN2	2201	broad.mit.edu	37	chr5	127728897	127728897	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccaacgccaggagaaaagcCattgcctccagggatgggga	13	12	0	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr5:127728897C>T	uc003kuu.2	-	10	1835	c.1396G>A	c.(1396-1398)GGC>AGC	p.G466S	FBN2_uc003kuv.2_Missense_Mutation_p.G433S	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	466					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGAGAAAAGCCATTGCCTCCA	0.587													T	127728897	T	T	127728897	3	4	69	1	0	0	0	0	1	0	0	0	5703	594	21	3	7566	3	FBN2	5	127728897	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08		127728897	53186363	25	4612											
PCDHB3	56132	broad.mit.edu	37	chr5	140481943	140481943	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgctgcagaacggctccgcGccctgcaccgagctggtgcc	13	18	0	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr5:140481943G>A	uc003lio.2	+	1	1710	c.1710G>A	c.(1708-1710)GCG>GCA	p.A570A	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	570	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGGCTCCGCGCCCTGCACCG	0.711													A	140481943	A	A	140481943	2	1	69	1	0	0	0	0	0	0	0	1	11543	1074	38	1		1	PCDHB3	5	140481943	Silent	SNP	G	TCGA-06-0879-01A-01W-0424-08	12753046	140481943	40433317	26	4613											
PCDHB8	56128	broad.mit.edu	37	chr5	140558277	140558277	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcactggatggtggctctcCgcccagatctggcactgctc	12	14	2	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr5:140558277C>T	uc011dai.1	+	1	848	c.662C>T	c.(661-663)CCG>CTG	p.P221L	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	221	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGCTCTCCGCCCAGATCT	0.522													T	140558277	T	T	140558277	3	4	69	1	0	0	0	0	1	0	0	0	11548	652	23	2	664	2	PCDHB8	5	140558277	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	76334	140558277	40356983	27	4614											
PCDHB13	56123	broad.mit.edu	37	chr5	140594357	140594357	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcactggatggtggctctcCgcccagatctggcactgctc	12	14	2	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr5:140594357C>T	uc003lja.1	+	1	849	c.662C>T	c.(661-663)CCG>CTG	p.P221L		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	221	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.P221L(1)		skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGCTCTCCGCCCAGATCT	0.532													T	140594357	T	T	140594357	3	4	69	1	0	0	0	0	1	0	0	0	11538	652	23	2	664	2	PCDHB13	5	140594357	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	36080	140594357	40320903	28	4615											
PCDHGA9	56107	broad.mit.edu	37	chr5	140782948	140782948	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtctggaagtaaaaattaaCgaaatcgcggttcctggagc	11	7	1	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr5:140782948C>T	uc003lkh.1	+	1	429	c.429C>T	c.(427-429)AAC>AAT	p.N143N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Silent_p.N143N	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	143	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAAAAATTAACGAAATCGCGG	0.473													T	140782948	T	T	140782948	2	4	69	1	0	0	0	0	0	0	0	1	11561	535	19	1		1	PCDHGA9	5	140782948	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08	188591	140782948	40132312	29	4616											
AFAP1L1	134265	broad.mit.edu	37	chr5	148687124	148687124	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcctgctgcggaaaaagcGtttcgggcagtgggccaagc	14	11	0	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr5:148687124G>A	uc003lqh.2	+	7	826	c.695G>A	c.(694-696)CGT>CAT	p.R232H	AFAP1L1_uc003lqg.3_Missense_Mutation_p.R232H|AFAP1L1_uc010jgy.2_Missense_Mutation_p.R232H	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	232	PH 1.						protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGAAAAAGCGTTTCGGGCAG	0.627													A	148687124	A	A	148687124	3	1	69	1	0	0	0	0	1	0	0	0	354	1145	40	1	721	1	AFAP1L1	5	148687124	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	7904176	148687124	32228136	30	4617											
FAT2	2196	broad.mit.edu	37	chr5	150901299	150901299	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctgccccacatgccacaCgtacacatggaccccagcag	7	19	0	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr5:150901299C>T	uc003lue.3	-	18	10868	c.10855G>A	c.(10855-10857)GTG>ATG	p.V3619M	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.V312M	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3619	Cadherin 32.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACATGCCACACGTACACATGG	0.627													T	150901299	T	T	150901299	3	4	69	1	0	0	0	0	1	0	0	0	5690	536	19	1	2218	1	FAT2	5	150901299	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	2214175	150901299	30013961	31	4618											
MDN1	23195	broad.mit.edu	37	chr6	90387330	90387330	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgctgacgatggacaatgcGctctggagatctaatgggtg	14	8	2	2	rs116003199	by1000genomes	TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr6:90387330G>A	uc003pnn.1	-	76	12614	c.12498C>T	c.(12496-12498)AGC>AGT	p.S4166S		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4166					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TGGACAATGCGCTCTGGAGAT	0.423													A	90387330	A	A	90387330	2	1	69	1	0	0	0	0	0	0	0	1	9415	1078	38	1		1	MDN1	6	90387330	Silent	SNP	G	TCGA-06-0879-01A-01W-0424-08		90387330	80727737	32	4619											
ASCC3	10973	broad.mit.edu	37	chr6	101248186	101248186	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttattacctttgtatccGcaattccttaggatcaaagc	5	10	1	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr6:101248186G>A	uc003pqk.2	-	6	1446	c.1117C>T	c.(1117-1119)CGG>TGG	p.R373W	ASCC3_uc011eai.1_Missense_Mutation_p.R275W|ASCC3_uc003pql.2_Missense_Mutation_p.R373W	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CTTTGTATCCGCAATTCCTTA	0.348													A	101248186	A	A	101248186	3	1	69	1	0	0	0	0	1	0	0	0	1033	1086	38	1	5639	1	ASCC3	6	101248186	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	10860856	101248186	69866881	33	4620											
TMEM200A	114801	broad.mit.edu	37	chr6	130762663	130762663	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaagtcatctatggctctcGgacctggggctggacagctc	12	12	3	0	rs140251464		TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr6:130762663G>A	uc003qca.2	+	3	1967	c.1096G>A	c.(1096-1098)GGA>AGA	p.G366R	TMEM200A_uc010kfh.2_Missense_Mutation_p.G366R|TMEM200A_uc010kfi.2_Missense_Mutation_p.G366R|TMEM200A_uc003qcb.2_Missense_Mutation_p.G366R	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	366	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TATGGCTCTCGGACCTGGGGC	0.522													A	130762663	A	A	130762663	3	1	69	1	0	0	0	0	1	0	0	0	16120	1117	39	2	1098	2	TMEM200A	6	130762663	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	29514477	130762663	40352404	34	4621											
EGFR	1956	broad.mit.edu	37	chr7	55249010	55249011	+	In_Frame_Ins	INS	-	ACAACCCCC	ACAACCCCC													ctacgtgatggccagcgtggINSacaacccccacgtgtgccgc							TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr7:55249010_55249011insACAACCCCC	uc003tqk.2	+	20	2554_2555	c.2308_2309insACAACCCCC	c.(2308-2310)GAC>GACAACCCCCAC	p.773_774insNPH	EGFR_uc010kzg.1_In_Frame_Ins_p.728_729insNPH|EGFR_uc011kco.1_In_Frame_Ins_p.720_721insNPH|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	773_774	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.H773_V774insNPH(12)|p.V769_D770insASV(12)|p.P772_H773insPR(11)|p.H773R(9)|p.H773_V774insPH(3)|p.H773_V774insH(3)|p.P772_H773insYNP(2)|p.P772_H773insX(2)|p.D770>GY(2)|p.H773Y(2)|p.V769_D770insMASVD(2)|p.V769_D770insGVV(2)|p.H773_V774insGH(1)|p.V769_D770insCV(1)|p.H773_V774insG(1)|p.D770N(1)|p.H773_V774insGNPH(1)|p.D770fs*61(1)|p.D770_P772>ASVDNR(1)|p.H773L(1)|p.V769_D770insGSV(1)|p.V769_D770insDNV(1)|p.P772_H773insDHP(1)|p.P772_H773insTHP(1)|p.P772_H773insDNP(1)|p.H773>NPY(1)|p.P772_H773insQV(1)|p.D770_N771insDG(1)|p.H773_V774>LM(1)|p.D770_N771>AGG(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGCCAGCGTGGACAACCCCCAC	0.649		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			ACAACCCCC	55249011	ACAACCCCC	ACAACCCCC	55249010	7	5	69	1	0	1	1	0	0	0	0	0	4967	1174	41	0	2650	0	EGFR	7	55249010	In_Frame_Ins	INS	-	TCGA-06-0879-01A-01W-0424-08		55249010	103889653	35	4622											
KEL	3792	broad.mit.edu	37	chr7	142649600	142649600	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccgctcctctcctcaccatgGgtggttgctctgtcagttcc	9	16	4	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr7:142649600G>T	uc003wcb.2	-	10	1409	c.1199C>A	c.(1198-1200)CCC>CAC	p.P400H		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	400	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					CCTCACCATGGGTGGTTGCTC	0.552													T	142649600	T	T	142649600	3	4	69	1	0	0	0	0	1	0	0	0	8142	1232	43	5	1039	5	KEL	7	142649600	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	87400590	142649600	16489063	36	4623											
ABP1	26	broad.mit.edu	37	chr7	150558187	150558187	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catccagagacactgtgatcGtgtggcctcgggacaacggc	13	12	0	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr7:150558187G>A	uc003why.1	+	6	6364	c.2146G>A	c.(2146-2148)GTG>ATG	p.V716M	ABP1_uc003whz.1_Missense_Mutation_p.V716M|ABP1_uc003wia.1_Missense_Mutation_p.V735M	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	716					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	CACTGTGATCGTGTGGCCTCG	0.602													A	150558187	A	A	150558187	3	1	69	1	0	0	0	0	1	0	0	0	98	1145	40	1	2160	1	ABP1	7	150558187	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	7908587	150558187	8580476	37	4624											
DOCK5	80005	broad.mit.edu	37	chr8	25225732	25225732	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggggacatgagaaaggaaatCggctttagaatccgggacat	14	6	0	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr8:25225732C>T	uc003xeg.2	+	32	3386	c.3249C>T	c.(3247-3249)ATC>ATT	p.I1083I	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Silent_p.I797I|DOCK5_uc003xei.2_Silent_p.I653I|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1083						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GAAAGGAAATCGGCTTTAGAA	0.413													T	25225732	T	T	25225732	2	4	69	1	0	0	0	0	0	0	0	1	4690	874	31	2		2	DOCK5	8	25225732	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08		25225732	121138290	38	4625											
CALML5	51806	broad.mit.edu	37	chr10	5541186	5541186	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggccctggccttcttcgcCgccgtcaggaactcctggaa	11	17	2	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr10:5541186C>T	uc001iic.2	-	1	348	c.216G>A	c.(214-216)GCG>GCA	p.A72A		NM_017422	NP_059118	Q9NZT1	CALL5_HUMAN	calmodulin-like 5	72	EF-hand 2.				epidermis development|signal transduction		calcium ion binding|protein binding				0						CCTTCTTCGCCGCCGTCAGGA	0.662													T	5541186	T	T	5541186	2	4	69	1	0	0	0	0	0	0	0	1	2589	639	23	2		2	CALML5	10	5541186	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08		5541186	129993561	39	4626											
SORCS3	22986	broad.mit.edu	37	chr10	106899184	106899184	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggaagagccagctactaCgtgtcttatcgaagagaggc	13	8	1	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr10:106899184C>T	uc001kyi.1	+	8	1469	c.1242C>T	c.(1240-1242)TAC>TAT	p.Y414Y		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	414	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CCAGCTACTACGTGTCTTATC	0.488													T	106899184	T	T	106899184	2	4	69	1	0	0	0	0	0	0	0	1	14932	547	19	1		1	SORCS3	10	106899184	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08	101357998	106899184	28635563	40	4627											
SPRYD5	84767	broad.mit.edu	37	chr11	55653041	55653041	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtacctcaactggcaagacaCggcagttcttgctcagtgct	10	12	3	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr11:55653041C>T	uc010rip.1	+	2	229	c.137C>T	c.(136-138)ACG>ATG	p.T46M	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	46	RING-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TGGCAAGACACGGCAGTTCTT	0.493													T	55653041	T	T	55653041	3	4	69	1	0	0	0	0	1	0	0	0	15110	536	19	1	139	1	SPRYD5	11	55653041	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08		55653041	79353475	41	4628											
MEN1	4221	broad.mit.edu	37	chr11	64575418	64575418	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcggtcctcgttgcccttgCcgtgccaggtgacctcagct	12	15	1	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr11:64575418C>T	uc001obj.2	-	3	687	c.614G>A	c.(613-615)GGC>GAC	p.G205D	MEN1_uc001obk.2_Missense_Mutation_p.G205D|MEN1_uc001obl.2_Intron|MEN1_uc001obm.2_Missense_Mutation_p.G200D|MEN1_uc001obn.2_Missense_Mutation_p.G205D|MEN1_uc001obo.2_Missense_Mutation_p.G205D|MEN1_uc001obp.2_Missense_Mutation_p.G200D|MEN1_uc001obq.2_Missense_Mutation_p.G205D|MEN1_uc001obr.2_Missense_Mutation_p.G205D	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	205					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						GTTGCCCTTGCCGTGCCAGGT	0.627			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				T	64575418	T	T	64575418	3	4	69	1	0	0	0	0	1	0	0	0	9472	739	26	3	1265	3	MEN1	11	64575418	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	8922377	64575418	70431098	42	4629											
CCDC81	60494	broad.mit.edu	37	chr11	86123501	86123501	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcaagaggaatattcccggAgtctcctgaaacaaatggat	10	8	1	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr11:86123501A>G	uc001pbx.1	+	11	1719	c.1291A>G	c.(1291-1293)AGT>GGT	p.S431G	CCDC81_uc001pbw.1_Missense_Mutation_p.S341G|CCDC81_uc010rtq.1_Missense_Mutation_p.S214G|CCDC81_uc001pby.1_Missense_Mutation_p.S166G	NM_001156474	NP_001149946	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81 isoform 1	431										skin(1)	1		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				ATATTCCCGGAGTCTCCTGAA	0.418													G	86123501	G	G	86123501	3	3	69	1	0	0	0	0	1	0	0	0	2855	304	11	4	1333	4	CCDC81	11	86123501	Missense_Mutation	SNP	A	TCGA-06-0879-01A-01W-0424-08	21548083	86123501	48883015	43	4630											
GLI1	2735	broad.mit.edu	37	chr12	57863263	57863263	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atcctgcagcagtgaccactCcccggcagggagtgcagcca	12	15	0	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr12:57863263C>T	uc001snx.2	+	11	1436	c.1358C>T	c.(1357-1359)TCC>TTC	p.S453F	GLI1_uc009zpq.2_Missense_Mutation_p.S325F	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	453					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			AGTGACCACTCCCCGGCAGGG	0.602													T	57863263	T	T	57863263	3	4	69	1	0	0	0	0	1	0	0	0	6437	855	30	3	1396	3	GLI1	12	57863263	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08		57863263	75988632	44	4631											
CAND1	55832	broad.mit.edu	37	chr12	67691247	67691247	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	acctgtctacttccccagttGaccagccctagacttgcagt	7	15	1	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr12:67691247G>T	uc001stn.2	+	5	989	c.552G>T	c.(550-552)TTG>TTT	p.L184F	CAND1_uc001sto.2_5'Flank	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	184	HEAT 5.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TTCCCCAGTTGACCAGCCCTA	0.368													T	67691247	T	T	67691247	3	4	69	1	0	0	0	0	1	0	0	0	2615	1281	45	5	570	5	CAND1	12	67691247	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	9827984	67691247	66160648	45	4632											
MGAT4C	25834	broad.mit.edu	37	chr12	86374059	86374059	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcctggaccatggcatcacGccaggaagaattaaagtctg	10	10	2	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr12:86374059G>A	uc001tai.3	-	8	1695	c.445C>T	c.(445-447)CGT>TGT	p.R149C	MGAT4C_uc001tal.3_Missense_Mutation_p.R149C|MGAT4C_uc001taj.3_Missense_Mutation_p.R149C|MGAT4C_uc001tak.3_Missense_Mutation_p.R149C|MGAT4C_uc010sum.1_Missense_Mutation_p.R173C|MGAT4C_uc001tah.3_Missense_Mutation_p.R149C	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	149	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						ATGGCATCACGCCAGGAAGAA	0.398													A	86374059	A	A	86374059	3	1	69	1	0	0	0	0	1	0	0	0	9547	1087	38	1	995	1	MGAT4C	12	86374059	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	18682812	86374059	47477836	46	4633											
C12orf63	374467	broad.mit.edu	37	chr12	97087577	97087577	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaagaaatctagaagcaagAatcctcaaggtatgttacaa	7	7	2	3			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr12:97087577A>G	uc001tet.1	+	12	1695	c.1617A>G	c.(1615-1617)AGA>AGG	p.R539R		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	539										skin(6)|ovary(1)	7						TAGAAGCAAGAATCCTCAAGG	0.308													G	97087577	G	G	97087577	2	3	69	1	0	0	0	0	0	0	0	1	1706	243	9	4		4	C12orf63	12	97087577	Silent	SNP	A	TCGA-06-0879-01A-01W-0424-08	10713518	97087577	36764318	47	4634											
RIMBP2	23504	broad.mit.edu	37	chr12	130926697	130926697	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgtccttgcccaccagcagCgtgcactgcagctcatccga	9	17	1	0	rs149109982		TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr12:130926697C>T	uc001uil.2	-	8	1313	c.1149G>A	c.(1147-1149)ACG>ACA	p.T383T	RIMBP2_uc001uim.2_Silent_p.T291T|RIMBP2_uc001uin.1_Silent_p.T42T	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	383						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CCACCAGCAGCGTGCACTGCA	0.637													T	130926697	T	T	130926697	2	4	69	1	0	0	0	0	0	0	0	1	13363	755	27	1		1	RIMBP2	12	130926697	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08	33839120	130926697	2925198	48	4635											
MTUS2	23281	broad.mit.edu	37	chr13	29600822	29600822	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gccaggtggacgcctcgctgGttccagtggggcttccatat	14	12	0	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr13:29600822G>T	uc001usl.3	+	1	2075	c.2017G>T	c.(2017-2019)GTT>TTT	p.V673F		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	663	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						CGCCTCGCTGGTTCCAGTGGG	0.587													T	29600822	T	T	29600822	3	4	69	1	0	0	0	0	1	0	0	0	9966	1261	44	5	2019	5	MTUS2	13	29600822	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08		29600822	85569056	49	4636											
BRCA2	675	broad.mit.edu	37	chr13	32911000	32911000	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aacgttgagctgttgccaccTgaaaaatacatgagagtagc	10	8	0	3			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr13:32911000T>C	uc001uub.1	+	11	2735	c.2508T>C	c.(2506-2508)CCT>CCC	p.P836P		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	836	Interaction with NPM1.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TGTTGCCACCTGAAAAATACA	0.308			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			C	32911000	C	C	32911000	2	2	69	1	0	0	0	0	0	0	0	1	1499	1567	55	4		4	BRCA2	13	32911000	Silent	SNP	T	TCGA-06-0879-01A-01W-0424-08	3310178	32911000	82258878	50	4637											
ARL11	115761	broad.mit.edu	37	chr13	50204952	50204952	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcttggtgctggccaacaaGcaggaggcacctgatgcact	12	11	1	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr13:50204952G>A	uc001vdf.1	+	2	515	c.369G>A	c.(367-369)AAG>AAA	p.K123K		NM_138450	NP_612459	Q969Q4	ARL11_HUMAN	ADP-ribosylation factor-like 11	123	GTP (By similarity).				small GTPase mediated signal transduction	intracellular	GTP binding|protein binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.119)|Kidney(9;0.169)	GBM - Glioblastoma multiforme(99;1.67e-09)		TGGCCAACAAGCAGGAGGCAC	0.602													A	50204952	A	A	50204952	2	1	69	1	0	0	0	0	0	0	0	1	927	962	34	3		3	ARL11	13	50204952	Silent	SNP	G	TCGA-06-0879-01A-01W-0424-08	17293952	50204952	64964926	51	4638											
PROZ	8858	broad.mit.edu	37	chr13	113812987	113812987	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtgggaatggcaggctgcGtcccactgctccagggcctg	17	12	0	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr13:113812987G>A	uc001vta.1	+	1	20	c.13G>A	c.(13-15)GTC>ATC	p.V5I	PROZ_uc010agr.1_Missense_Mutation_p.V5I	NM_003891	NP_003882	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma	5					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	GGCAGGCTGCGTCCCACTGCT	0.657													A	113812987	A	A	113812987	3	1	69	1	0	0	0	0	1	0	0	0	12562	1145	40	1	15	1	PROZ	13	113812987	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	63608035	113812987	1356891	52	4639											
PPP4R4	57718	broad.mit.edu	37	chr14	94703972	94703972	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggatgaaggcagcagtgtaCgacttgcagcttttgaaact	13	7	0	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr14:94703972C>T	uc001ycs.1	+	8	956	c.802C>T	c.(802-804)CGA>TGA	p.R268*		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	268	HEAT 2.					cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						CAGCAGTGTACGACTTGCAGC	0.358													T	94703972	T	T	94703972	4	4	69	1	0	0	0	0	0	1	0	0	12405	528	19	1	905	1	PPP4R4	14	94703972	Nonsense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08		94703972	12645568	53	4640											
AQR	9716	broad.mit.edu	37	chr15	35166951	35166951	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aacaaagcgagtgaagagagActgctccatgtttgagtact	11	7	0	4			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr15:35166951A>G	uc001ziv.2	-	29	3533	c.3352T>C	c.(3352-3354)TCT>CCT	p.S1118P		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	1118						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		GTGAAGAGAGACTGCTCCATG	0.428													G	35166951	G	G	35166951	3	3	69	1	0	0	0	0	1	0	0	0	835	275	10	4	1133	4	AQR	15	35166951	Missense_Mutation	SNP	A	TCGA-06-0879-01A-01W-0424-08		35166951	67364441	54	4641											
KIAA1024	23251	broad.mit.edu	37	chr15	79750063	79750063	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagtgacattttccgatttcTtgatgacatgagcatcagtg	9	8	2	4			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr15:79750063T>C	uc002bew.1	+	2	1649	c.1574T>C	c.(1573-1575)CTT>CCT	p.L525P	KIAA1024_uc010unk.1_Missense_Mutation_p.L525P	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	525						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						TTCCGATTTCTTGATGACATG	0.502													C	79750063	C	C	79750063	3	2	69	1	0	0	0	0	1	0	0	0	8205	1609	56	4	1576	4	KIAA1024	15	79750063	Missense_Mutation	SNP	T	TCGA-06-0879-01A-01W-0424-08	44583112	79750063	22781329	55	4642											
SLC7A5	8140	broad.mit.edu	37	chr16	87873313	87873313	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgggtagcggctcaccacggCcacggcctcggacgacagca	14	16	1	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr16:87873313C>A	uc002fkm.2	-	5	1006	c.934G>T	c.(934-936)GCC>TCC	p.A312S		NM_003486	NP_003477	Q01650	LAT1_HUMAN	solute carrier family 7 (cationic amino acid	312					blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding				0				BRCA - Breast invasive adenocarcinoma(80;0.049)		CTCACCACGGCCACGGCCTCG	0.652													A	87873313	A	A	87873313	3	1	69	1	0	0	0	0	1	0	0	0	14700	739	26	5	613	5	SLC7A5	16	87873313	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08		87873313	2481440	56	4643											
PLSCR3	57048	broad.mit.edu	37	chr17	7296587	7296587	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcgggcgccacagcacagaCgggcgcagcagttgctctcc	15	15	1	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr17:7296587C>T	uc002ggm.1	-	5	592	c.383G>A	c.(382-384)CGT>CAT	p.R128H	PLSCR3_uc002ggl.2_Missense_Mutation_p.R128H|PLSCR3_uc002ggq.1_Intron|PLSCR3_uc002ggn.1_Missense_Mutation_p.R128H|PLSCR3_uc002ggo.1_Missense_Mutation_p.R128H|PLSCR3_uc002ggp.1_Intron|PLSCR3_uc002ggr.1_Missense_Mutation_p.R128H|PLSCR3_uc010cmg.1_Missense_Mutation_p.R128H	NM_020360	NP_065093	Q9NRY6	PLS3_HUMAN	phospholipid scramblase 3	128	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|calcium-dependent protein binding|phospholipid scramblase activity|SH3 domain binding				0		Prostate(122;0.173)				ACAGCACAGACGGGCGCAGCA	0.716													T	7296587	T	T	7296587	3	4	69	1	0	0	0	0	1	0	0	0	12111	536	19	1	520	1	PLSCR3	17	7296587	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08		7296587	73898623	57	4644											
KRT15	3866	broad.mit.edu	37	chr17	39673161	39673161	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctcatccaggactcggcGcaagccgttgatgtcagcct	11	14	2	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr17:39673161G>A	uc002hwy.2	-	3	828	c.637C>T	c.(637-639)CGC>TGC	p.R213C	KRT15_uc002hwz.2_Missense_Mutation_p.R115C|KRT15_uc002hxa.2_Missense_Mutation_p.R48C|KRT15_uc002hxb.1_Missense_Mutation_p.R48C	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	213	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				AGGACTCGGCGCAAGCCGTTG	0.592													A	39673161	A	A	39673161	3	1	69	1	0	0	0	0	1	0	0	0	8452	1087	38	1	757	1	KRT15	17	39673161	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	32376574	39673161	41522049	58	4645											
PITPNC1	26207	broad.mit.edu	37	chr17	65528973	65528973	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccatgaacagagtgaccGgggagaaggggtggaggtcg	19	7	0	4			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr17:65528973G>A	uc002jgc.2	+	2	451	c.104G>A	c.(103-105)CGG>CAG	p.R35Q	PITPNC1_uc002jgb.2_Missense_Mutation_p.R35Q	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	35					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			CAGAGTGACCGGGGAGAAGGG	0.532													A	65528973	A	A	65528973	3	1	69	1	0	0	0	0	1	0	0	0	11949	1116	39	2	110	2	PITPNC1	17	65528973	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	25855812	65528973	15666237	59	4646											
ELAVL1	1994	broad.mit.edu	37	chr19	8028639	8028639	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccggaggaggcgtttcctgGcacgttgacgccagagagcc	16	12	0	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr19:8028639G>A	uc002mjb.2	-	6	876	c.709C>T	c.(709-711)CCA>TCA	p.P237S		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	237					3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						GCGTTTCCTGGCACGTTGACG	0.632													A	8028639	A	A	8028639	3	1	69	1	0	0	0	0	1	0	0	0	5049	1203	42	3	275	3	ELAVL1	19	8028639	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08		8028639	51100344	60	4647											
PDE4A	5141	broad.mit.edu	37	chr19	10574494	10574494	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggaacatggtgcactgtgCcgacctcagcaaccccacca	9	17	1	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr19:10574494C>T	uc002moj.2	+	14	1877	c.1769C>T	c.(1768-1770)GCC>GTC	p.A590V	PDE4A_uc002mok.2_Missense_Mutation_p.A564V|PDE4A_uc002mol.2_Missense_Mutation_p.A529V|PDE4A_uc002mom.2_Missense_Mutation_p.A351V|PDE4A_uc002mon.2_Missense_Mutation_p.A45V|PDE4A_uc002moo.2_Missense_Mutation_p.A256V	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	590	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	GTGCACTGTGCCGACCTCAGC	0.617													T	10574494	T	T	10574494	3	4	69	1	0	0	0	0	1	0	0	0	11639	739	26	3	2280	3	PDE4A	19	10574494	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08	2545855	10574494	48554489	61	4648											
ZNF91	7644	broad.mit.edu	37	chr19	23542219	23542219	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tattttttagtagagaagggGtttcactgtgttagccagga	12	4	1	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr19:23542219G>A	uc002nre.2	-	4	3675	c.3562C>T	c.(3562-3564)CCC>TCC	p.P1188S	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.P1156S	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	1188						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				tagagaaggggtttcactgtg	0.01													A	23542219	A	A	23542219	3	1	69	1	0	0	0	0	1	0	0	0	18197	1261	44	3	17	3	ZNF91	19	23542219	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08	12967725	23542219	35586764	62	4649											
CYP2A13	1553	broad.mit.edu	37	chr19	41597726	41597726	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caagggctggaggacttcatCgccaagaaggtggagcacaa	14	9	1	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr19:41597726C>T	uc002opt.2	+	5	753	c.744C>T	c.(742-744)ATC>ATT	p.I248I		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	248					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	AGGACTTCATCGCCAAGAAGG	0.557													T	41597726	T	T	41597726	2	4	69	1	0	0	0	0	0	0	0	1	4161	874	31	2		2	CYP2A13	19	41597726	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08	18055507	41597726	17531257	63	4650											
PPP1R12C	54776	broad.mit.edu	37	chr19	55624065	55624065	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtagccacaggaggcggcCacgtgcagtggcgtccagcc	16	13	0	0			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr19:55624065C>T	uc002qix.2	-	2	436	c.420G>A	c.(418-420)GTG>GTA	p.V140V	PPP1R12C_uc010yfs.1_Silent_p.V66V|PPP1R12C_uc002qiy.2_Silent_p.V140V	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	140	ANK 2.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		AGGAGGCGGCCACGTGCAGTG	0.667													T	55624065	T	T	55624065	2	4	69	1	0	0	0	0	0	0	0	1	12356	581	21	3		3	PPP1R12C	19	55624065	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08	14026339	55624065	3504918	64	4651											
PREX1	57580	broad.mit.edu	37	chr20	47309262	47309262	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttcagtgttgattcgaccCctgaagatgtagagggagcc	12	9	1	4			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr20:47309262C>T	uc002xtw.1	-	8	1007	c.984G>A	c.(982-984)AGG>AGA	p.R328R		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	328	PH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			TGATTCGACCCCTGAAGATGT	0.458													T	47309262	T	T	47309262	2	4	69	1	0	0	0	0	0	0	0	1	12476	622	22	3		3	PREX1	20	47309262	Silent	SNP	C	TCGA-06-0879-01A-01W-0424-08		47309262	15716258	65	4652											
TPTE	7179	broad.mit.edu	37	chr21	10906987	10906987	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	caaaatctgatggataaattCtccgtgctttttgtttatgt	7	6	2	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr21:10906987C>A	uc002yip.1	-	24	1942	c.1574G>T	c.(1573-1575)AGA>ATA	p.R525I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.R507I|TPTE_uc002yir.1_Missense_Mutation_p.R487I|TPTE_uc010gkv.1_Missense_Mutation_p.R387I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	525	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGATAAATTCTCCGTGCTTT	0.358													A	10906987	A	A	10906987	3	1	69	1	0	0	0	0	1	0	0	0	16427	913	32	5	85	5	TPTE	21	10906987	Missense_Mutation	SNP	C	TCGA-06-0879-01A-01W-0424-08		10906987	37222908	66	4653											
B3GALT5	10317	broad.mit.edu	37	chr21	41033203	41033203	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccaagagcgtcccatacatTaaactggaagacgtgtttgt	9	9	0	2			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr21:41033203T>G	uc002yyb.1	+	5	1309	c.717T>G	c.(715-717)ATT>ATG	p.I239M	B3GALT5_uc002yye.2_Missense_Mutation_p.I239M|B3GALT5_uc002yyi.1_Missense_Mutation_p.I239M|B3GALT5_uc002yyj.1_Missense_Mutation_p.I239M|B3GALT5_uc002yyk.1_Missense_Mutation_p.I239M|B3GALT5_uc002yyl.1_Missense_Mutation_p.I239M|B3GALT5_uc002yym.1_Missense_Mutation_p.I239M	NM_033173	NP_149363	Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta	239	Lumenal (Potential).				protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1		Prostate(19;2.55e-06)				TCCCATACATTAAACTGGAAG	0.562													G	41033203	G	G	41033203	3	3	69	1	0	0	0	0	1	0	0	0	1250	1742	61	5	719	5	B3GALT5	21	41033203	Missense_Mutation	SNP	T	TCGA-06-0879-01A-01W-0424-08	30126216	41033203	7096692	67	4654											
SLC35E4	339665	broad.mit.edu	37	chr22	31032455	31032455	+	Frame_Shift_Del	DEL	G	-	-													cggatgtgccgctgcccgccGgagcaccatgatggcaggat							TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr22:31032455delG	uc003ais.1	+	1	663	c.18delG	c.(16-18)CCGfs	p.P6fs	SLC35E4_uc003ait.2_5'UTR	NM_001001479	NP_001001479	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	6						integral to membrane					0						GCTGCCCGCCGGAGCACCATG	0.701													-	31032455	-	-	31032455	7	5	69	1	0	1	0	1	0	0	0	0	14587	1103	39	0	20	0	SLC35E4	22	31032455	Frame_Shift_Del	DEL	G	TCGA-06-0879-01A-01W-0424-08		31032455	20272111	68	4655											
GTSE1	51512	broad.mit.edu	37	chr22	46708130	46708130	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccctgacaaacctgccccGggtgctgtcaatgtgccggc	11	16	1	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chr22:46708130G>A	uc011aqy.1	+	5	1067	c.855G>A	c.(853-855)CCG>CCA	p.P285P	GTSE1_uc011aqz.1_Silent_p.P132P	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	266					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		AACCTGCCCCGGGTGCTGTCA	0.577													A	46708130	A	A	46708130	2	1	69	1	0	0	0	0	0	0	0	1	6885	1103	39	2		2	GTSE1	22	46708130	Silent	SNP	G	TCGA-06-0879-01A-01W-0424-08	15675675	46708130	4596436	69	4656											
AFF2	2334	broad.mit.edu	37	chrX	148072810	148072810	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcatgaccaatcttgtccGctacgttcgccaaggactgt	9	13	1	1			TCGA-06-0879-01A-01W-0424-08	TCGA-06-0879-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	f96b8966-e0c2-4fb6-b3f6-e76d7953d537	d7f78904-a226-488c-aff8-cbbd2d13882d	g.chrX:148072810G>A	uc004fcp.2	+	21	4363	c.3884G>A	c.(3883-3885)CGC>CAC	p.R1295H	AFF2_uc004fcq.2_Missense_Mutation_p.R1285H|AFF2_uc004fcr.2_Missense_Mutation_p.R1256H|AFF2_uc011mxb.1_Missense_Mutation_p.R1260H|AFF2_uc004fcs.2_Missense_Mutation_p.R1260H|AFF2_uc011mxc.1_Missense_Mutation_p.R936H	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1295					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AATCTTGTCCGCTACGTTCGC	0.527													A	148072810	A	A	148072810	3	1	69	1	0	0	0	0	1	0	0	0	357	1087	38	1	4021	1	AFF2	23	148072810	Missense_Mutation	SNP	G	TCGA-06-0879-01A-01W-0424-08		148072810	7197750	70	4657											
EXTL1	2134	broad.mit.edu	37	chr1	26360290	26360290	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccatggtggctggggctacaCtgctgagaggaccaacgaat	14	10	0	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr1:26360290C>T	uc001blf.2	+	9	2489	c.1622C>T	c.(1621-1623)ACT>ATT	p.T541I		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	541	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGGCTACACTGCTGAGAGG	0.577													T	26360290	T	T	26360290	3	4	70	1	0	0	0	0	1	0	0	0	5325	565	20	3	1656	3	EXTL1	1	26360290	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08		26360290	222890331	1	4658											
COL24A1	255631	broad.mit.edu	37	chr1	86590905	86590905	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgatattgtcagacatgtTtaggagagagctaaatttct	10	4	2	3			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr1:86590905T>G	uc001dlj.2	-	3	1156	c.1114A>C	c.(1114-1116)AAC>CAC	p.N372H	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.N372H	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	372					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCAGACATGTTTAGGAGAGAG	0.378													G	86590905	G	G	86590905	3	3	70	1	0	0	0	0	1	0	0	0	3683	1841	64	5	4262	5	COL24A1	1	86590905	Missense_Mutation	SNP	T	TCGA-06-0881-01A-02W-0424-08	60230615	86590905	162659716	2	4659											
OR2G2	81470	broad.mit.edu	37	chr1	247751819	247751819	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccatcattctggtttctcGtctggaacccaagcttcata	6	13	5	0			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr1:247751819G>A	uc010pyy.1	+	1	158	c.158G>A	c.(157-159)CGT>CAT	p.R53H		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTGGTTTCTCGTCTGGAACCC	0.418													A	247751819	A	A	247751819	3	1	70	1	0	0	0	0	1	0	0	0	10998	1145	40	1	160	1	OR2G2	1	247751819	Missense_Mutation	SNP	G	TCGA-06-0881-01A-02W-0424-08	161160914	247751819	1498802	3	4660											
SCN9A	6335	broad.mit.edu	37	chr2	167141062	167141062	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaaccagggagaccacaccGttgcagtccacagcactgtg	10	14	1	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr2:167141062G>A	uc010fpl.2	-	12	2216	c.1875C>T	c.(1873-1875)AAC>AAT	p.N625N	uc002udp.2_Intron|SCN9A_uc002udr.1_Silent_p.N496N|SCN9A_uc002uds.1_Silent_p.N496N|SCN9A_uc002udt.1_Silent_p.N496N	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	625						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	AGACCACACCGTTGCAGTCCA	0.562													A	167141062	A	A	167141062	2	1	70	1	0	0	0	0	0	0	0	1	13925	1136	40	1		1	SCN9A	2	167141062	Silent	SNP	G	TCGA-06-0881-01A-02W-0424-08		167141062	76058311	4	4661											
TTN	7273	broad.mit.edu	37	chr2	179438641	179438641	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttttatttctaactttgctGtgccttccagctcttttcca	4	11	2	0			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr2:179438641G>C	uc010zfg.1	-	275	64738	c.64514C>G	c.(64513-64515)ACA>AGA	p.T21505R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T15200R|TTN_uc010zfi.1_Missense_Mutation_p.T15133R|TTN_uc010zfj.1_Missense_Mutation_p.T15008R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22432							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACTTTGCTGTGCCTTCCAG	0.413													C	179438641	C	C	179438641	3	2	70	1	0	0	0	0	1	0	0	0	16732	1377	48	5	35909	5	TTN	2	179438641	Missense_Mutation	SNP	G	TCGA-06-0881-01A-02W-0424-08	12297579	179438641	63760732	5	4662											
TTN	7273	broad.mit.edu	37	chr2	179615121	179615121	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgatgatgaacagatgaaagAgttaatattgaatagttttc	9	2	0	7			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr2:179615121A>G	uc002unb.2	-	46	12230	c.12006T>C	c.(12004-12006)ACT>ACC	p.T4002T	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	9818							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGATGAAAGAGTTAATATTG	0.333													G	179615121	G	G	179615121	2	3	70	1	0	0	0	0	0	0	0	1	16732	291	11	4		4	TTN	2	179615121	Silent	SNP	A	TCGA-06-0881-01A-02W-0424-08	176480	179615121	63584252	6	4663											
TTN	7273	broad.mit.edu	37	chr2	179647637	179647637	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgcttcgcgaatcataagaCgagcaattccactctggaag	9	10	2	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr2:179647637C>T	uc010zfg.1	-	18	3220	c.2996G>A	c.(2995-2997)CGT>CAT	p.R999H	TTN_uc010zfh.1_Missense_Mutation_p.R953H|TTN_uc010zfi.1_Missense_Mutation_p.R953H|TTN_uc010zfj.1_Missense_Mutation_p.R953H|TTN_uc002unb.2_Missense_Mutation_p.R999H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	999							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATCATAAGACGAGCAATTCC	0.493													T	179647637	T	T	179647637	3	4	70	1	0	0	0	0	1	0	0	0	16732	536	19	1	108372	1	TTN	2	179647637	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08	32516	179647637	63551736	7	4664											
COL6A3	1293	broad.mit.edu	37	chr2	238245018	238245018	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcaggggccggctttgcagCggctggcttcacagatggct	16	12	1	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr2:238245018C>T	uc002vwl.2	-	40	9010	c.8725G>A	c.(8725-8727)GCT>ACT	p.A2909T	COL6A3_uc002vwo.2_Missense_Mutation_p.A2703T|COL6A3_uc010znj.1_Missense_Mutation_p.A2302T|COL6A3_uc002vwj.2_Missense_Mutation_p.A290T	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2909	Nonhelical region.|Ala-rich.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGCTTTGCAGCGGCTGGCTTC	0.582													T	238245018	T	T	238245018	3	4	70	1	0	0	0	0	1	0	0	0	3701	768	27	1	828	1	COL6A3	2	238245018	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08	58597381	238245018	4954355	8	4665											
DAG1	1605	broad.mit.edu	37	chr3	49570453	49570453	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtaccccaaccagagtgtgCccgagaccactcctctgaac	8	16	1	3			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr3:49570453C>T	uc003cxc.3	+	3	2927	c.2509C>T	c.(2509-2511)CCC>TCC	p.P837S		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	837	Pro-rich.|Required for interaction with CAV3.|Cytoplasmic (Potential).				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CCAGAGTGTGCCCGAGACCAC	0.637													T	49570453	T	T	49570453	3	4	70	1	0	0	0	0	1	0	0	0	4225	739	26	3	2515	3	DAG1	3	49570453	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08		49570453	148451977	9	4666											
ANKRD17	26057	broad.mit.edu	37	chr4	73962983	73962983	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcccttcactgatagtttcTgacaatctttaacaaagaga	6	9	3	3			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr4:73962983T>G	uc003hgp.2	-	27	5145	c.5028A>C	c.(5026-5028)TCA>TCC	p.S1676S	ANKRD17_uc003hgo.2_Silent_p.S1563S|ANKRD17_uc003hgq.2_Silent_p.S1425S|ANKRD17_uc003hgr.2_Silent_p.S1675S	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1676	Ser-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGATAGTTTCTGACAATCTTT	0.333													G	73962983	G	G	73962983	2	3	70	1	0	0	0	0	0	0	0	1	646	1567	55	5		5	ANKRD17	4	73962983	Silent	SNP	T	TCGA-06-0881-01A-02W-0424-08		73962983	117191293	10	4667											
FGA	2243	broad.mit.edu	37	chr4	155506815	155506815	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgtggagtctcctctgttgTaactcgtgctactagtaaat	9	8	2	0			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr4:155506815T>C	uc003iod.1	-	5	1824	c.1766A>G	c.(1765-1767)TAC>TGC	p.Y589C	FGA_uc003ioe.1_Missense_Mutation_p.Y589C|FGA_uc003iof.1_3'UTR	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	589	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCCTCTGTTGTAACTCGTGCT	0.443													C	155506815	C	C	155506815	3	2	70	1	0	0	0	0	1	0	0	0	5830	1638	57	4	886	4	FGA	4	155506815	Missense_Mutation	SNP	T	TCGA-06-0881-01A-02W-0424-08	81543832	155506815	35647461	11	4668											
CDH18	1016	broad.mit.edu	37	chr5	19520824	19520825	+	Missense_Mutation	DNP	GG	AC	AC													attccctggcaagttcgggtGgattgtcattgacatccaga							TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr5:19520824_19520825GG>AC	uc003jgc.2	-	9	1830_1831	c.1453_1454CC>GT	c.(1453-1455)CCA>GTA	p.P485V	CDH18_uc003jgd.2_Missense_Mutation_p.P485V|CDH18_uc011cnm.1_Missense_Mutation_p.P485V	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	485	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AAGTTCGGGTGGATTGTCATTG	0.381													AC	19520825	AC	AC	19520824	3	1	70	1	0	0	0	0	1	0	0	0	3103	1348	47	3	934	3	CDH18	5	19520824	Missense_Mutation	DNP	GG	TCGA-06-0881-01A-02W-0424-08		19520824	161394436	12	4669											
PCDHB16	57717	broad.mit.edu	37	chr5	140563145	140563145	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgcactcttctcctgcaggtGgtggacgtgaatgacaatcc	11	11	2	2			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr5:140563145G>T	uc003liv.2	+	1	2166	c.1011G>T	c.(1009-1011)GTG>GTT	p.V337V	PCDHB16_uc010jfw.1_Silent_p.V9V	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	337	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTGCAGGTGGTGGACGTGA	0.502													T	140563145	T	T	140563145	2	4	70	1	0	0	0	0	0	0	0	1	11541	1335	47	5		5	PCDHB16	5	140563145	Silent	SNP	G	TCGA-06-0881-01A-02W-0424-08	121042321	140563145	40352115	13	4670											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720392	140720392	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgagccgggactcttctcGgtgggtctgcacacgggcga	16	12	3	0			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr5:140720392G>A	uc003ljk.1	+	1	2039	c.1854G>A	c.(1852-1854)TCG>TCA	p.S618S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.S618S	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	618	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTCTTCTCGGTGGGTCTGC	0.677													A	140720392	A	A	140720392	2	1	70	1	0	0	0	0	0	0	0	1	11554	1103	39	2		2	PCDHGA2	5	140720392	Silent	SNP	G	TCGA-06-0881-01A-02W-0424-08	157247	140720392	40194868	14	4671											
TUBB	203068	broad.mit.edu	37	chr6	30690337	30690337	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgggaggtgatcagtgatgaAcatggcatcgaccccaccgg	14	10	1	3			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr6:30690337A>G	uc003nrl.2	+	2	208	c.81A>G	c.(79-81)GAA>GAG	p.E27E	TUBB_uc003nrk.1_Silent_p.E27E|TUBB_uc011dmq.1_5'UTR	NM_178014	NP_821133	P07437	TBB5_HUMAN	tubulin, beta	27					cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding			ovary(1)	1					Colchicine(DB01394)|Vinblastine(DB00570)|Vincristine(DB00541)|Vinorelbine(DB00361)	TCAGTGATGAACATGGCATCG	0.552													G	30690337	G	G	30690337	2	3	70	1	0	0	0	0	0	0	0	1	16749	40	2	4		4	TUBB	6	30690337	Silent	SNP	A	TCGA-06-0881-01A-02W-0424-08		30690337	140424730	15	4672											
DPCR1	135656	broad.mit.edu	37	chr6	30919762	30919762	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaacacccagaaaagaccaCgtcaaccacagagaaaacca	6	13	1	4			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr6:30919762C>T	uc003nsg.2	+	2	3521	c.3521C>T	c.(3520-3522)ACG>ATG	p.T1174M		NM_080870	NP_543146	Q3MIW9	DPCR1_HUMAN	diffuse panbronchiolitis critical region 1	305	Extracellular (Potential).|Thr-rich.					integral to membrane					0						GAAAAGACCACGTCAACCACA	0.468													T	30919762	T	T	30919762	3	4	70	1	0	0	0	0	1	0	0	0	4712	536	19	1	3527	1	DPCR1	6	30919762	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08	229425	30919762	140195305	16	4673											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	70	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08		55221822	103916841	17	4674											
RSBN1L	222194	broad.mit.edu	37	chr7	77378833	77378833	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacacaaagagaatgaaaaaCggaagcgtccgaaaatgtat	9	6	0	2			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr7:77378833C>T	uc010ldt.1	+	3	840	c.796C>T	c.(796-798)CGG>TGG	p.R266W	RSBN1L_uc003ugm.2_Missense_Mutation_p.R48W	NM_198467	NP_940869	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	266	Lys-rich.					nucleus				ovary(1)	1						GAATGAAAAACGGAAGCGTCC	0.353													T	77378833	T	T	77378833	3	4	70	1	0	0	0	0	1	0	0	0	13697	527	19	1	806	1	RSBN1L	7	77378833	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08	22157011	77378833	81759830	18	4675											
SEMA3E	9723	broad.mit.edu	37	chr7	82997239	82997239	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaaggtgattttacggaccGtatggacaaagctatgctct	10	9	1	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr7:82997239G>A	uc003uhy.1	-	17	2457	c.1991C>T	c.(1990-1992)ACG>ATG	p.T664M		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	664	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TTTACGGACCGTATGGACAAA	0.458													A	82997239	A	A	82997239	3	1	70	1	0	0	0	0	1	0	0	0	14028	1145	40	1	340	1	SEMA3E	7	82997239	Missense_Mutation	SNP	G	TCGA-06-0881-01A-02W-0424-08	5618406	82997239	76141424	19	4676											
MYOM2	9172	broad.mit.edu	37	chr8	2040299	2040299	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtggactgctgtgtggccGgaaccaacctctgggagccc	14	13	1	0			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr8:2040299G>A	uc003wpx.3	+	16	2092	c.1954G>A	c.(1954-1956)GGA>AGA	p.G652R	MYOM2_uc011kwi.1_Missense_Mutation_p.G77R	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	652	Fibronectin type-III 3.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTGTGTGGCCGGAACCAACCT	0.607													A	2040299	A	A	2040299	3	1	70	1	0	0	0	0	1	0	0	0	10092	1117	39	2	2012	2	MYOM2	8	2040299	Missense_Mutation	SNP	G	TCGA-06-0881-01A-02W-0424-08		2040299	144323723	20	4677											
CSMD1	64478	broad.mit.edu	37	chr8	2855644	2855644	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaaattcacgacatcattcaGgttgaactcactgccattag	7	10	4	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr8:2855644G>C	uc011kwk.1	-	54	8659	c.8269C>G	c.(8269-8271)CTG>GTG	p.L2757V	CSMD1_uc011kwj.1_Missense_Mutation_p.L2086V|CSMD1_uc010lrg.2_Missense_Mutation_p.L767V	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2757	Extracellular (Potential).|Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACATCATTCAGGTTGAACTCA	0.527													C	2855644	C	C	2855644	3	2	70	1	0	0	0	0	1	0	0	0	3944	991	35	5	2496	5	CSMD1	8	2855644	Missense_Mutation	SNP	G	TCGA-06-0881-01A-02W-0424-08	815345	2855644	143508378	21	4678											
CDH17	1015	broad.mit.edu	37	chr8	95188833	95188833	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaaacgtgggtcgattgtcGttgatgtccttcacttttat	10	7	1	2	rs148638200	byFrequency	TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr8:95188833G>A	uc003ygh.2	-	5	485	c.360C>T	c.(358-360)AAC>AAT	p.N120N	CDH17_uc011lgo.1_Silent_p.N120N|CDH17_uc011lgp.1_Silent_p.N120N	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	120	Extracellular (Potential).|Cadherin 1.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTCGATTGTCGTTGATGTCCT	0.483													A	95188833	A	A	95188833	2	1	70	1	0	0	0	0	0	0	0	1	3102	1136	40	1		1	CDH17	8	95188833	Silent	SNP	G	TCGA-06-0881-01A-02W-0424-08	92333189	95188833	51175189	22	4679											
FAM75C1	441452	broad.mit.edu	37	chr9	90536517	90536517	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagcccttgaggagtgactcAggaagtgatttattaagacg	12	6	1	4			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr9:90536517A>T	uc010mqi.2	+	4	1724	c.1695A>T	c.(1693-1695)TCA>TCT	p.S565S	FAM75C1_uc004apq.3_Silent_p.S548S	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GGAGTGACTCAGGAAGTGATT	0.507													T	90536517	T	T	90536517	2	4	70	1	0	0	0	0	0	0	0	1	5623	175	7	5		5	FAM75C1	9	90536517	Silent	SNP	A	TCGA-06-0881-01A-02W-0424-08		90536517	50676914	23	4680											
OR13C4	138804	broad.mit.edu	37	chr9	107288808	107288808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcttcctgtggccgagttcGttcgcaagatggtgtagagg	15	8	1	2	rs139144967		TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr9:107288808G>A	uc011lvn.1	-	1	683	c.683C>T	c.(682-684)ACG>ATG	p.T228M		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGCCGAGTTCGTTCGCAAGAT	0.403													A	107288808	A	A	107288808	3	1	70	1	0	0	0	0	1	0	0	0	10936	1145	40	1	275	1	OR13C4	9	107288808	Missense_Mutation	SNP	G	TCGA-06-0881-01A-02W-0424-08	16752291	107288808	33924623	24	4681											
PTEN	5728	broad.mit.edu	37	chr10	89692830	89692830	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaacttatcaaacccttttGtgaagatcttgaccaatggc	7	9	2	4			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr10:89692830G>A	uc001kfb.2	+	6	1345	c.314G>A	c.(313-315)TGT>TAT	p.C105Y		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	105	Phosphatase tensin-type.		C -> F (in BZS; loss of phosphatase activity towards Ins(1,3,4,5)P4).|C -> Y (in BZS).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.C105F(6)|p.C105W(4)|p.R55fs*1(4)|p.C105S(3)|p.?(2)|p.Y27fs*1(2)|p.C105Y(2)|p.Y27_N212>Y(2)|p.C105fs*2(1)|p.C105fs*1(1)|p.C105G(1)|p.C105R(1)|p.F56fs*2(1)|p.P103fs*3(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AAACCCTTTTGTGAAGATCTT	0.373		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89692830	A	A	89692830	3	1	70	1	0	0	0	0	1	0	0	0	12738	1377	48	3	332	3	PTEN	10	89692830	Missense_Mutation	SNP	G	TCGA-06-0881-01A-02W-0424-08		89692830	45841917	25	4682											
SYNJ2BP	55333	broad.mit.edu	37	chr14	70839825	70839825	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccccttcacctcgatgtccTataggtccattctgcacctg	6	16	2	0			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr14:70839825T>C	uc001xmc.3	-	4	448	c.321A>G	c.(319-321)ATA>ATG	p.I107M	SYNJ2BP_uc010arc.2_RNA	NM_018373	NP_060843	P57105	SYJ2B_HUMAN	synaptojanin 2 binding protein	107	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane					0				all cancers(60;0.00367)|BRCA - Breast invasive adenocarcinoma(234;0.00716)|OV - Ovarian serous cystadenocarcinoma(108;0.0377)		CTCGATGTCCTATAGGTCCAT	0.473													C	70839825	C	C	70839825	3	2	70	1	0	0	0	0	1	0	0	0	15451	1512	53	4	120	4	SYNJ2BP	14	70839825	Missense_Mutation	SNP	T	TCGA-06-0881-01A-02W-0424-08		70839825	36509715	26	4683											
DNAH3	55567	broad.mit.edu	37	chr16	20994175	20994175	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgaagggaacatccgcaggCggttcctgaaggcatcccct	13	13	0	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr16:20994175C>T	uc010vbe.1	-	49	7727	c.7727G>A	c.(7726-7728)CGC>CAC	p.R2576H	DNAH3_uc010vbd.1_Missense_Mutation_p.R11H	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2576	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CATCCGCAGGCGGTTCCTGAA	0.507													T	20994175	T	T	20994175	3	4	70	1	0	0	0	0	1	0	0	0	4603	768	27	1	4678	1	DNAH3	16	20994175	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08		20994175	69360578	27	4684											
CDH8	1006	broad.mit.edu	37	chr16	61687974	61687974	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attaatggttcatttttatgCcgccgtagagttacaaacag	8	7	1	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr16:61687974C>T	uc002eog.1	-	12	2190	c.1938G>A	c.(1936-1938)CGG>CGA	p.R646R		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	646	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R646Q(1)		ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CATTTTTATGCCGCCGTAGAG	0.388													T	61687974	T	T	61687974	2	4	70	1	0	0	0	0	0	0	0	1	3116	726	26	3		3	CDH8	16	61687974	Silent	SNP	C	TCGA-06-0881-01A-02W-0424-08	40693799	61687974	28666779	28	4685											
FXR2	9513	broad.mit.edu	37	chr17	7507356	7507357	+	Frame_Shift_Ins	INS	-	C	C													atcatccgcacccgggccagINSccaccagccacaaggttcct							TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr17:7507356_7507357insC	uc002gia.1	-	4	497_498	c.270_271insG	c.(268-273)TGGCTGfs	p.W90fs	FXR2_uc010vud.1_Frame_Shift_Ins_p.W90fs	NM_004860	NP_004851	P51116	FXR2_HUMAN	fragile X mental retardation syndrome related	90_91						cytosolic large ribosomal subunit	protein binding|RNA binding	p.?(1)			0				READ - Rectum adenocarcinoma(115;0.17)		ACCCGGGCCAGCCACCAGCCAC	0.441													C	7507357	C	C	7507356	7	5	70	1	0	1	1	0	0	0	0	0	6116	962	34	0	1706	0	FXR2	17	7507356	Frame_Shift_Ins	INS	-	TCGA-06-0881-01A-02W-0424-08		7507356	73687854	29	4686											
MYH3	4621	broad.mit.edu	37	chr17	10537429	10537429	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagctcagtgctcaaggagCgggactccttcagggatgcc	14	11	3	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr17:10537429C>T	uc002gmq.1	-	31	4504	c.4427G>A	c.(4426-4428)CGC>CAC	p.R1476H		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1476	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						GCTCAAGGAGCGGGACTCCTT	0.493													T	10537429	T	T	10537429	3	4	70	1	0	0	0	0	1	0	0	0	10036	768	27	1	1435	1	MYH3	17	10537429	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08	3030073	10537429	70657781	30	4687											
CCDC47	57003	broad.mit.edu	37	chr17	61830101	61830101	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaggacccagaatacttacCattaaatgtaaacaacagtg	6	8	0	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr17:61830101C>T	uc002jbs.3	-	10	1429	c.1093G>A	c.(1093-1095)GTG>ATG	p.V365M	CCDC47_uc010ddx.2_Missense_Mutation_p.V365M|CCDC47_uc002jbt.2_Missense_Mutation_p.V365M	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	365						integral to membrane	protein binding				0						GAATACTTACCATTAAATGTA	0.373											OREG0031500	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	T	61830101	T	T	61830101	3	4	70	1	0	0	0	0	1	0	0	0	2818	608	21	3	374	3	CCDC47	17	61830101	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08	51292672	61830101	19365109	31	4688											
FCGBP	8857	broad.mit.edu	37	chr19	40376323	40376323	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggttcctacctcatagtagAcaccattgtggtagcagcca	9	11	1	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr19:40376323A>G	uc002omp.3	-	25	11989	c.11981T>C	c.(11980-11982)GTC>GCC	p.V3994A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	3994	Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTCATAGTAGACACCATTGTG	0.557													G	40376323	G	G	40376323	3	3	70	1	0	0	0	0	1	0	0	0	5778	275	10	4	4284	4	FCGBP	19	40376323	Missense_Mutation	SNP	A	TCGA-06-0881-01A-02W-0424-08		40376323	18752660	32	4689											
SIGLEC8	27181	broad.mit.edu	37	chr19	51960862	51960862	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggggcccggggaggacaCggaggccccaatccaggaga	18	11	0	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr19:51960862C>T	uc002pwt.2	-	2	653	c.586G>A	c.(586-588)GTG>ATG	p.V196M	SIGLEC8_uc010yda.1_Intron|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Intron	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	196	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GGGGAGGACACGGAGGCCCCA	0.657													T	51960862	T	T	51960862	3	4	70	1	0	0	0	0	1	0	0	0	14314	536	19	1	937	1	SIGLEC8	19	51960862	Missense_Mutation	SNP	C	TCGA-06-0881-01A-02W-0424-08	11584539	51960862	7168121	33	4690											
NLRP8	126205	broad.mit.edu	37	chr19	56459235	56459235	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaatcggttgtctttatcGtggacactgaggtgttctct	10	9	2	1			TCGA-06-0881-01A-02W-0424-08	TCGA-06-0881-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	1069a9d0-9978-4c01-8516-947200264314	8abdb9fd-4a21-4289-932e-1b69c4bb9f1a	g.chr19:56459235G>A	uc002qmh.2	+	1	38	c.-33G>A	c.(-35--31)TCGTG>TCATG		NLRP8_uc010etg.2_Translation_Start_Site	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8							cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TGTCTTTATCGTGGACACTGA	0.448													A	56459235	A	A	56459235	1	1	70	1	0	0	0	0	0	0	0	0	10483	1160	40	1		1	NLRP8	19	56459235	Translation_Start_Site	SNP	G	TCGA-06-0881-01A-02W-0424-08	4498373	56459235	2669748	34	4691											
C1orf177	163747	broad.mit.edu	37	chr1	55280638	55280638	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagagaagaaatgcaaacccGtcaaccagcccccattcctg	7	14	1	2			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr1:55280638G>A	uc001cyb.3	+	8	1030	c.976G>A	c.(976-978)GTC>ATC	p.V326I	C1orf177_uc001cya.3_Missense_Mutation_p.V326I	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	326											0						ATGCAAACCCGTCAACCAGCC	0.552													A	55280638	A	A	55280638	3	1	71	1	0	0	0	0	1	0	0	0	2017	1145	40	1	1006	1	C1orf177	1	55280638	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08		55280638	193969983	1	4692											
FCRL4	83417	broad.mit.edu	37	chr1	157551332	157551332	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcacaaacctgacttcctcCgacgccagcagtgaaacagc	8	15	0	2	rs150354637		TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr1:157551332C>T	uc001fqw.2	-	7	1374	c.1238G>A	c.(1237-1239)CGG>CAG	p.R413Q	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	413	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				TGACTTCCTCCGACGCCAGCA	0.602													T	157551332	T	T	157551332	3	4	71	1	0	0	0	0	1	0	0	0	5797	652	23	2	333	2	FCRL4	1	157551332	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08	102270694	157551332	91699289	2	4693											
PAPPA2	60676	broad.mit.edu	37	chr1	176661413	176661413	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagaccaacaagtccctcacTatccactggctgcctcctat	5	17	1	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr1:176661413T>C	uc001gkz.2	+	6	3747	c.2583T>C	c.(2581-2583)ACT>ACC	p.T861T	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	861					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGTCCCTCACTATCCACTGGC	0.502													C	176661413	C	C	176661413	2	2	71	1	0	0	0	0	0	0	0	1	11433	1509	53	4		4	PAPPA2	1	176661413	Silent	SNP	T	TCGA-06-0882-01A-01W-0424-08	19110081	176661413	72589208	3	4694											
RAB3GAP2	25782	broad.mit.edu	37	chr1	220335581	220335581	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agcagaaaatcttttaactaAgaacgtattccacatcatca	4	9	3	2			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr1:220335581A>C	uc010puk.1	-	28	3348	c.3184T>G	c.(3184-3186)TTA>GTA	p.L1062V	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.L642V|RAB3GAP2_uc001hmh.2_Missense_Mutation_p.L6V	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	1062					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		CTTTTAACTAAGAACGTATTC	0.284													C	220335581	C	C	220335581	3	2	71	1	0	0	0	0	1	0	0	0	12936	69	3	5	1029	5	RAB3GAP2	1	220335581	Missense_Mutation	SNP	A	TCGA-06-0882-01A-01W-0424-08	43674168	220335581	28915040	4	4695											
OTOF	9381	broad.mit.edu	37	chr2	26686908	26686908	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaccaggcggcagcctgcgCgggggatgtcctcccagtgc	16	15	0	0	rs143889717		TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr2:26686908C>T	uc002rhk.2	-	40	5154	c.5027G>A	c.(5026-5028)CGC>CAC	p.R1676H	OTOF_uc010yla.1_Missense_Mutation_p.R406H|OTOF_uc002rhh.2_Missense_Mutation_p.R909H|OTOF_uc002rhi.2_Missense_Mutation_p.R986H|OTOF_uc002rhj.2_Missense_Mutation_p.R909H	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1676	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAGCCTGCGCGGGGGATGTC	0.667													T	26686908	T	T	26686908	3	4	71	1	0	0	0	0	1	0	0	0	11303	768	27	1	1179	1	OTOF	2	26686908	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08		26686908	216512465	5	4696											
TTN	7273	broad.mit.edu	37	chr2	179463526	179463526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcagacttgctggacccaCgccagcagcattgattgcat	11	12	0	2			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr2:179463526C>T	uc010zfg.1	-	240	49431	c.49207G>A	c.(49207-49209)GTG>ATG	p.V16403M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V10098M|TTN_uc010zfi.1_Missense_Mutation_p.V10031M|TTN_uc010zfj.1_Missense_Mutation_p.V9906M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17330							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGGACCCACGCCAGCAGCA	0.428													T	179463526	T	T	179463526	3	4	71	1	0	0	0	0	1	0	0	0	16732	536	19	1	51070	1	TTN	2	179463526	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08	152776618	179463526	63735847	6	4697											
CPS1	1373	broad.mit.edu	37	chr2	211469880	211469880	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agtcagtgacaggttggaaaGaaatagaatatgaagtggtt	13	2	1	4			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr2:211469880G>C	uc002vee.3	+	17	2023	c.1891G>C	c.(1891-1893)GAA>CAA	p.E631Q	CPS1_uc010fur.2_Missense_Mutation_p.E637Q|CPS1_uc010fus.2_Missense_Mutation_p.E180Q	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	631	ATP-grasp 1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AGGTTGGAAAGAAATAGAATA	0.408													C	211469880	C	C	211469880	3	2	71	1	0	0	0	0	1	0	0	0	3823	943	33	5	1979	5	CPS1	2	211469880	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	32006354	211469880	31729493	7	4698											
COL4A4	1286	broad.mit.edu	37	chr2	227917071	227917071	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggtccaggttccccaggtGttcccttttgtgaaatgata	11	9	0	2			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr2:227917071G>A	uc010zlt.1	-	32	3572	c.2918C>T	c.(2917-2919)ACA>ATA	p.T973I		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	973	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTCCCCAGGTGTTCCCTTTTG	0.403													A	227917071	A	A	227917071	3	1	71	1	0	0	0	0	1	0	0	0	3693	1377	48	3	2222	3	COL4A4	2	227917071	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	16447191	227917071	15282302	8	4699											
CNTN6	27255	broad.mit.edu	37	chr3	1427473	1427473	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cccagtcaatgttaccaccaAaaagtctcgtaagtatgcat	6	11	2	0	rs143460057		TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr3:1427473A>G	uc003boz.2	+	20	2963	c.2696A>G	c.(2695-2697)AAA>AGA	p.K899R	CNTN6_uc011asj.1_Missense_Mutation_p.K827R|CNTN6_uc003bpa.2_Missense_Mutation_p.K899R	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	899					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GTTACCACCAAAAAGTCTCGT	0.453													G	1427473	G	G	1427473	3	3	71	1	0	0	0	0	1	0	0	0	3645	14	1	4	2770	4	CNTN6	3	1427473	Missense_Mutation	SNP	A	TCGA-06-0882-01A-01W-0424-08		1427473	196594957	9	4700											
CCR5	1234	broad.mit.edu	37	chr3	46414783	46414783	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atcgataggtacctggctgtCgtccatgctgtgtttgcttt	11	9	0	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr3:46414783C>T	uc003cpo.3	+	3	512	c.390C>T	c.(388-390)GTC>GTT	p.V130V	CCR5_uc010hjd.2_Silent_p.V130V	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	130	Cytoplasmic (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	ACCTGGCTGTCGTCCATGCTG	0.478													T	46414783	T	T	46414783	2	4	71	1	0	0	0	0	0	0	0	1	2944	871	31	2		2	CCR5	3	46414783	Silent	SNP	C	TCGA-06-0882-01A-01W-0424-08	44987310	46414783	151607647	10	4701											
STAB1	23166	broad.mit.edu	37	chr3	52543899	52543899	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catacagactgcggctgtgtCcatggtctctgcgacaaccg	11	13	1	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr3:52543899C>T	uc003dej.2	+	23	2435	c.2361C>T	c.(2359-2361)GTC>GTT	p.V787V		NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	787	Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCGGCTGTGTCCATGGTCTCT	0.632													T	52543899	T	T	52543899	2	4	71	1	0	0	0	0	0	0	0	1	15236	842	30	3		3	STAB1	3	52543899	Silent	SNP	C	TCGA-06-0882-01A-01W-0424-08	6129116	52543899	145478531	11	4702											
KDR	3791	broad.mit.edu	37	chr4	55984940	55984940	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgccactctgattattgggCcaaagccagtccaagtccct	8	14	1	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr4:55984940C>T	uc003has.2	-	3	491	c.189G>A	c.(187-189)TGG>TGA	p.W63*	KDR_uc003hat.1_Nonsense_Mutation_p.W63*|KDR_uc011bzx.1_Nonsense_Mutation_p.W63*	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	63	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GATTATTGGGCCAAAGCCAGT	0.448			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			T	55984940	T	T	55984940	4	4	71	1	0	0	0	0	0	1	0	0	8139	740	26	3	3993	3	KDR	4	55984940	Nonsense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08		55984940	135169336	12	4703											
HELT	391723	broad.mit.edu	37	chr4	185941817	185941817	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagcgcagcagcacagccCcttcctgacaccggtgcagg	11	18	0	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr4:185941817C>T	uc011ckq.1	+	4	875	c.875C>T	c.(874-876)CCC>CTC	p.P292L	HELT_uc011cko.1_Missense_Mutation_p.P207L|HELT_uc003ixa.3_Missense_Mutation_p.P206L|HELT_uc011ckp.1_Missense_Mutation_p.P150L	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	292	Pro-rich.						DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		CAGCACAGCCCCTTCCTGACA	0.736													T	185941817	T	T	185941817	3	4	71	1	0	0	0	0	1	0	0	0	7048	623	22	3	889	3	HELT	4	185941817	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08	129956877	185941817	5212459	13	4704											
KDM1B	221656	broad.mit.edu	37	chr6	18213891	18213891	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctgctcactttgcagattgCcttgcaatttccgtatagat	7	10	2	2			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr6:18213891C>A	uc003nco.1	+	12	1454	c.1379C>A	c.(1378-1380)GCC>GAC	p.A460D	KDM1B_uc003ncn.1_Missense_Mutation_p.A431D|KDM1B_uc003ncp.1_Missense_Mutation_p.A16D|KDM1B_uc003ncq.1_Missense_Mutation_p.A16D	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	663					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						TTGCAGATTGCCTTGCAATTT	0.463													A	18213891	A	A	18213891	3	1	71	1	0	0	0	0	1	0	0	0	8123	739	26	5	1342	5	KDM1B	6	18213891	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08		18213891	152901176	14	4705											
VPS52	6293	broad.mit.edu	37	chr6	33232605	33232605	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgcaatgttacggaaccGgagaacaatgtggatacaga	12	7	0	2			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr6:33232605G>A	uc003odm.1	-	13	1564	c.1354C>T	c.(1354-1356)CGG>TGG	p.R452W	VPS52_uc003odn.1_Missense_Mutation_p.R263W	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	452					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						TTACGGAACCGGAGAACAATG	0.483													A	33232605	A	A	33232605	3	1	71	1	0	0	0	0	1	0	0	0	17211	1115	39	2	849	2	VPS52	6	33232605	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	15018714	33232605	137882462	15	4706											
TFAP2B	7021	broad.mit.edu	37	chr6	50810943	50810943	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcacgcacggcttcggcgcCccggccatttgcgccgcgct	12	18	1	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr6:50810943C>A	uc003pag.2	+	7	1387	c.1221C>A	c.(1219-1221)GCC>GCA	p.A407A		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	407				QLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLIT HGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTS GEGPGSKTGDKEEKHRK -> GNFVKNLRIYWRRTGHR (in Ref. 1; CAA71047).	nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					GCTTCGGCGCCCCGGCCATTT	0.627													A	50810943	A	A	50810943	2	1	71	1	0	0	0	0	0	0	0	1	15785	610	22	5		5	TFAP2B	6	50810943	Silent	SNP	C	TCGA-06-0882-01A-01W-0424-08	17578338	50810943	120304124	16	4707											
TRIP6	7205	broad.mit.edu	37	chr7	100466151	100466151	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccacctcctgcctaccgcaCgggctccctgaagccaaatc	8	19	0	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr7:100466151C>T	uc003uww.2	+	4	568	c.398C>T	c.(397-399)ACG>ATG	p.T133M	TRIP6_uc010lhk.1_RNA	NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	133					focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)					GCCTACCGCACGGGCTCCCTG	0.637													T	100466151	T	T	100466151	3	4	71	1	0	0	0	0	1	0	0	0	16556	536	19	1	412	1	TRIP6	7	100466151	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08		100466151	58672512	17	4708											
GRM8	2918	broad.mit.edu	37	chr7	126086220	126086220	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagttcacttttcacctcGccatttggtctgtcatttcc	6	13	4	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr7:126086220G>A	uc003vlr.2	-	9	2948	c.2637C>T	c.(2635-2637)GGC>GGT	p.G879G	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.G879G|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	879	Cytoplasmic (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TTTTCACCTCGCCATTTGGTC	0.453										HNSCC(24;0.065)			A	126086220	A	A	126086220	2	1	71	1	0	0	0	0	0	0	0	1	6803	1074	38	1		1	GRM8	7	126086220	Silent	SNP	G	TCGA-06-0882-01A-01W-0424-08	25620069	126086220	33052443	18	4709											
RAB11FIP1	80223	broad.mit.edu	37	chr8	37732071	37732071	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctggggagccctcggagaGgaaattggaggtctcggttc	17	8	2	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr8:37732071G>A	uc003xkm.1	-	3	1628	c.1584C>T	c.(1582-1584)TCC>TCT	p.S528S	RAB11FIP1_uc010lvz.1_Silent_p.S376S|RAB11FIP1_uc003xkn.1_Silent_p.S528S|RAB11FIP1_uc003xkl.1_5'Flank|RAB11FIP1_uc003xko.1_5'Flank|RAB11FIP1_uc003xkp.1_Silent_p.S376S	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	528					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CCCTCGGAGAGGAAATTGGAG	0.547													A	37732071	A	A	37732071	2	1	71	1	0	0	0	0	0	0	0	1	12893	987	35	3		3	RAB11FIP1	8	37732071	Silent	SNP	G	TCGA-06-0882-01A-01W-0424-08		37732071	108631951	19	4710											
ARMC3	219681	broad.mit.edu	37	chr10	23297794	23297794	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggatctcccatagaagacaAatcagagccagcttctggac	9	11	3	3			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr10:23297794A>G	uc001irm.3	+	16	2062	c.1979A>G	c.(1978-1980)AAA>AGA	p.K660R	ARMC3_uc010qcv.1_Missense_Mutation_p.K653R|ARMC3_uc010qcw.1_Missense_Mutation_p.K397R	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	660							binding				0						ATAGAAGACAAATCAGAGCCA	0.378													G	23297794	G	G	23297794	3	3	71	1	0	0	0	0	1	0	0	0	952	14	1	4	2037	4	ARMC3	10	23297794	Missense_Mutation	SNP	A	TCGA-06-0882-01A-01W-0424-08		23297794	112236953	20	4711											
PTEN	5728	broad.mit.edu	37	chr10	89711900	89711900	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactattcccagtcagaggcGctatgtgtattattatagct	8	8	1	1	rs121913294		TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr10:89711900G>A	uc001kfb.2	+	7	1549	c.518G>A	c.(517-519)CGC>CAC	p.R173H		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	173	Phosphatase tensin-type.		R -> C (in endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3; retains ability to bind phospholipid membranes).|R -> P (loss of phosphatase activity towards Ins(1,3,4,5)P4).|R -> H (loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R173C(32)|p.R173H(22)|p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.R173fs*10(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G165_K342del(1)|p.G165_*404del(1)|p.R173R(1)|p.R173P(1)|p.R172fs*5(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGTCAGAGGCGCTATGTGTAT	0.348	R173H(RL952_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89711900	A	A	89711900	3	1	71	1	0	0	0	0	1	0	0	0	12738	1087	38	1	540	1	PTEN	10	89711900	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	66414106	89711900	45822847	21	4712											
ST5	6764	broad.mit.edu	37	chr11	8752166	8752166	+	Frame_Shift_Del	DEL	C	-	-													tcctgctcatcctccggaggCccttgaaatcaaaggtcttt							TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr11:8752166delC	uc001mgt.2	-	3	857	c.671delG	c.(670-672)GGCfs	p.G224fs	ST5_uc009yfr.2_Intron|ST5_uc001mgu.2_Intron|ST5_uc001mgv.2_Frame_Shift_Del_p.G224fs|ST5_uc010rbq.1_Intron|ST5_uc001mgw.1_Frame_Shift_Del_p.G224fs	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	224					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CCTCCGGAGGCCCTTGAAATC	0.642													-	8752166	-	-	8752166	7	5	71	1	0	1	0	1	0	0	0	0	15219	739	26	0	2814	0	ST5	11	8752166	Frame_Shift_Del	DEL	C	TCGA-06-0882-01A-01W-0424-08		8752166	126254350	22	4713											
OR8J3	81168	broad.mit.edu	37	chr11	55904404	55904404	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cagtatccagtgagtggttgGtttggggctgcaaatacata	13	6	0	1	rs143365733	byFrequency	TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr11:55904404G>C	uc010riz.1	-	1	791	c.791C>G	c.(790-792)ACC>AGC	p.T264S		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					TGAGTGGTTGGTTTGGGGCTG	0.428													C	55904404	C	C	55904404	3	2	71	1	0	0	0	0	1	0	0	0	11242	1261	44	5	158	5	OR8J3	11	55904404	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	47152238	55904404	79102112	23	4714											
SLC22A20	440044	broad.mit.edu	37	chr11	64981482	64981482	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agaacttcacggccgctgtcCccccccaccactgccggggc	10	20	1	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr11:64981482C>A	uc010roc.1	+	1	136	c.133C>A	c.(133-135)CCC>ACC	p.P45T	SLC22A20_uc010rob.1_Missense_Mutation_p.P45T	NM_001004326	NP_001004326	A6NK97	S22AK_HUMAN	solute carrier family 22, member 20	45	Extracellular (Potential).				ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)	1						GGCCGCTGTCCCCCCCCACCA	0.692													A	64981482	A	A	64981482	3	1	71	1	0	0	0	0	1	0	0	0	14451	623	22	5	141	5	SLC22A20	11	64981482	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08	9077078	64981482	70025034	24	4715											
TIGD3	220359	broad.mit.edu	37	chr11	65124539	65124539	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actgaagacgagaagggggaCagagagggtgcctttgagcc	17	7	0	5			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr11:65124539C>G	uc001odo.3	+	2	1423	c.1260C>G	c.(1258-1260)GAC>GAG	p.D420E		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	420					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						AGAAGGGGGACAGAGAGGGTG	0.587													G	65124539	G	G	65124539	3	3	71	1	0	0	0	0	1	0	0	0	15894	477	17	5	1262	5	TIGD3	11	65124539	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08	143057	65124539	69881977	25	4716											
ITGB7	3695	broad.mit.edu	37	chr12	53590514	53590514	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctgaatggtgactggcagCgctccagccgggtggggcag	18	10	0	2			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr12:53590514C>T	uc009zmv.2	-	5	736	c.665G>A	c.(664-666)CGC>CAC	p.R222H	ITGB7_uc001scc.2_Missense_Mutation_p.R222H|ITGB7_uc010snz.1_RNA|ITGB7_uc010soa.1_3'UTR	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	222	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						TGACTGGCAGCGCTCCAGCCG	0.622													T	53590514	T	T	53590514	3	4	71	1	0	0	0	0	1	0	0	0	7900	768	27	1	1775	1	ITGB7	12	53590514	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08		53590514	80261381	26	4717											
LHFP	10186	broad.mit.edu	37	chr13	40175282	40175282	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaggcataaagaaccccacGcaggaggtggcagcacaaag	12	10	0	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr13:40175282G>A	uc001uxf.2	-	2	583	c.72C>T	c.(70-72)TGC>TGT	p.C24C		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	24						integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		AGAACCCCACGCAGGAGGTGG	0.537			T	HMGA2	lipoma								A	40175282	A	A	40175282	2	1	71	1	0	0	0	0	0	0	0	1	8763	1079	38	1		1	LHFP	13	40175282	Silent	SNP	G	TCGA-06-0882-01A-01W-0424-08		40175282	74994596	27	4718											
C14orf182	283551	broad.mit.edu	37	chr14	50472507	50472507	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttttccagggttgccatcCgacctgtcatttggtctgtg	10	11	2	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr14:50472507C>T	uc001wxi.1	-	1	1732	c.11G>A	c.(10-12)CGG>CAG	p.R4Q		NM_001012706	NP_001012724	A1A4T8	CN182_HUMAN	hypothetical protein LOC283551	4											0						GGTTGCCATCCGACCTGTCAT	0.507													T	50472507	T	T	50472507	3	4	71	1	0	0	0	0	1	0	0	0	1765	652	23	2	324	2	C14orf182	14	50472507	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08		50472507	56877033	28	4719											
TDRD9	122402	broad.mit.edu	37	chr14	104493271	104493271	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcacggaggagtcctacgagTccaaggtgtgtgctttcgcc	13	11	1	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr14:104493271T>C	uc001yom.3	+	28	3307	c.3277T>C	c.(3277-3279)TCC>CCC	p.S1093P	TDRD9_uc001yon.3_Missense_Mutation_p.S831P	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	1093					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				GTCCTACGAGTCCAAGGTGTG	0.582													C	104493271	C	C	104493271	3	2	71	1	0	0	0	0	1	0	0	0	15733	1667	58	4	3387	4	TDRD9	14	104493271	Missense_Mutation	SNP	T	TCGA-06-0882-01A-01W-0424-08	54020764	104493271	2856269	29	4720											
PLCB2	5330	broad.mit.edu	37	chr15	40596215	40596215	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcaccttactttgatacGtccagtataagtagtagccc	6	11	1	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr15:40596215G>A	uc001zld.2	-	2	450	c.149C>T	c.(148-150)ACG>ATG	p.T50M	PLCB2_uc010bbo.2_Missense_Mutation_p.T50M|PLCB2_uc010ucm.1_Missense_Mutation_p.T50M|PLCB2_uc001zle.3_Missense_Mutation_p.T50M	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	50					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		ACTTTGATACGTCCAGTATAA	0.527													A	40596215	A	A	40596215	3	1	71	1	0	0	0	0	1	0	0	0	12028	1145	40	1	3532	1	PLCB2	15	40596215	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08		40596215	61935177	30	4721											
RPAP1	26015	broad.mit.edu	37	chr15	41810014	41810014	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acctcatctgccagcagccaTgttttctgcagcatactcct	6	15	3	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr15:41810014T>C	uc001zod.2	-	24	4138	c.4014A>G	c.(4012-4014)ACA>ACG	p.T1338T	RPAP1_uc001zoc.2_Silent_p.T357T	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1338						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CCAGCAGCCATGTTTTCTGCA	0.562													C	41810014	C	C	41810014	2	2	71	1	0	0	0	0	0	0	0	1	13541	1451	51	4		4	RPAP1	15	41810014	Silent	SNP	T	TCGA-06-0882-01A-01W-0424-08	1213799	41810014	60721378	31	4722											
ABCC1	4363	broad.mit.edu	37	chr16	16225756	16225756	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gaggacctggacttcgttctCaggcacatcaatgtcacgat	10	11	3	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr16:16225756C>T	uc010bvi.2	+	27	4105	c.3930C>T	c.(3928-3930)CTC>CTT	p.L1310L	ABCC1_uc010bvj.2_Silent_p.L1251L|ABCC1_uc010bvk.2_Silent_p.L1254L|ABCC1_uc010bvl.2_Silent_p.L1310L|ABCC1_uc010bvm.2_Silent_p.L1195L|ABCC1_uc002del.3_Silent_p.L1204L	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1310	ABC transporter 2.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ACTTCGTTCTCAGGCACATCA	0.607													T	16225756	T	T	16225756	2	4	71	1	0	0	0	0	0	0	0	1	49	813	29	3		3	ABCC1	16	16225756	Silent	SNP	C	TCGA-06-0882-01A-01W-0424-08		16225756	74128997	32	4723											
RLTPR	146206	broad.mit.edu	37	chr16	67683169	67683169	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccacagggagaccctggaCgacgtcctgcaccggattgt	13	14	0	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr16:67683169C>T	uc002etn.2	+	19	1821	c.1701C>T	c.(1699-1701)GAC>GAT	p.D567D	RLTPR_uc010cel.1_Silent_p.D560D|RLTPR_uc010vjr.1_Silent_p.D531D	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	567	LRR 12.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		AGACCCTGGACGACGTCCTGC	0.637													T	67683169	T	T	67683169	2	4	71	1	0	0	0	0	0	0	0	1	13394	535	19	1		1	RLTPR	16	67683169	Silent	SNP	C	TCGA-06-0882-01A-01W-0424-08	51457413	67683169	22671584	33	4724											
DRG2	1819	broad.mit.edu	37	chr17	18007951	18007951	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagagaggccagacttcAcagacgccatcattctccgg	10	14	3	3			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr17:18007951A>T	uc002gsh.1	+	11	965	c.910A>T	c.(910-912)ACA>TCA	p.T304S	DRG2_uc002gsi.1_RNA|DRG2_uc002gsj.1_Missense_Mutation_p.T304S	NM_001388	NP_001379	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	304					signal transduction		GTP binding			ovary(1)	1	all_neural(463;0.228)					GCCAGACTTCACAGACGCCAT	0.607													T	18007951	T	T	18007951	3	4	71	1	0	0	0	0	1	0	0	0	4762	159	6	5	952	5	DRG2	17	18007951	Missense_Mutation	SNP	A	TCGA-06-0882-01A-01W-0424-08		18007951	63187259	34	4725											
FAM18B	51030	broad.mit.edu	37	chr17	18708852	18708852	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttttttttttgtcttttgcAgaacactggagatgatcaga	8	5	2	4	rs2589696		TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr17:18708852A>G	uc002gum.2	+	7	617	c.592_splice	c.e7-2	p.N198_splice	FAM18B_uc002gun.2_Splice_Site_p.N134_splice	NM_016078	NP_057162	Q9NYZ1	F18B1_HUMAN	hypothetical protein LOC51030							integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (53;0.0872)|READ - Rectum adenocarcinoma(1115;0.0967)		TGTCTTTTGCAGAACACTGGA	0.368													G	18708852	G	G	18708852	5	3	71	1	0	0	0	0	0	0	1	0	5519	202	7	4	616	4	FAM18B	17	18708852	Splice_Site	SNP	A	TCGA-06-0882-01A-01W-0424-08	700901	18708852	62486358	35	4726											
SLFN12	55106	broad.mit.edu	37	chr17	33749828	33749828	+	Missense_Mutation	SNP	C	T	T													ttccaaatctagtcctattcCatcttttgtataactatagt							TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr17:33749828C>T	uc002hji.3	-	2	597	c.220G>A	c.(220-222)GGA>AGA	p.G74R	SLFN12_uc002hjj.3_Missense_Mutation_p.G74R|SLFN12_uc010cts.2_Missense_Mutation_p.G74R	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	74							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTCCTATTCCATCTTTTGTA	0.363													T	33749828	T	T	33749828	3	4	71	1	0	0	0	0	1	0	0	0	14734	603	21	3	1528	3	SLFN12	17	33749828	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08	15040976	33749828	47445382	36	4727	7	2									
SLFN12	55106	broad.mit.edu	37	chr17	33749831	33749831	+	Missense_Mutation	SNP	C	T	T													caaatctagtcctattccatCttttgtataactatagtctt							TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr17:33749831C>T	uc002hji.3	-	2	594	c.217G>A	c.(217-219)GAT>AAT	p.D73N	SLFN12_uc002hjj.3_Missense_Mutation_p.D73N|SLFN12_uc010cts.2_Missense_Mutation_p.D73N	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	73							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCTATTCCATCTTTTGTATAA	0.368													T	33749831	T	T	33749831	3	4	71	1	0	0	0	0	1	0	0	0	14734	913	32	3	1531	3	SLFN12	17	33749831	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08	3	33749831	47445379	37	4728	7	2									
LYZL6	57151	broad.mit.edu	37	chr17	34261842	34261842	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agccagtagaagagtggccgGcctgaacagtgcaacctcca	12	12	0	3			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr17:34261842G>T	uc002hkj.1	-	4	555	c.405C>A	c.(403-405)GGC>GGA	p.G135G	LYZL6_uc002hkk.1_Silent_p.G135G	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor	135					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGAGTGGCCGGCCTGAACAGT	0.537													T	34261842	T	T	34261842	2	4	71	1	0	0	0	0	0	0	0	1	9134	1190	42	5		5	LYZL6	17	34261842	Silent	SNP	G	TCGA-06-0882-01A-01W-0424-08	512011	34261842	46933368	38	4729											
HOXB9	3219	broad.mit.edu	37	chr17	46703491	46703491	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ggctggaagctgcacgagggGaactccaggtgctccgcgtg	17	11	0	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr17:46703491G>C	uc002inx.2	-	1	345	c.141C>G	c.(139-141)TTC>TTG	p.F47L		NM_024017	NP_076922	P17482	HXB9_HUMAN	homeobox B9	47					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TGCACGAGGGGAACTCCAGGT	0.687													C	46703491	C	C	46703491	3	2	71	1	0	0	0	0	1	0	0	0	7308	1165	41	5	619	5	HOXB9	17	46703491	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	12441649	46703491	34491719	39	4730			1	16		2	2	48	G		7.590948e-05
HOXB9	3219	broad.mit.edu	37	chr17	46703538	46703538	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgccgcgagctcgcgtactGgccagaaggaaacttggctg	14	12	0	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr17:46703538G>A	uc002inx.2	-	1	298	c.94C>T	c.(94-96)CAG>TAG	p.Q32*		NM_024017	NP_076922	P17482	HXB9_HUMAN	homeobox B9	32					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTCGCGTACTGGCCAGAAGGA	0.622													A	46703538	A	A	46703538	4	1	71	1	0	0	0	0	0	1	0	0	7308	1357	47	3	666	3	HOXB9	17	46703538	Nonsense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	47	46703538	34491672	40	4731			1	16		2	2	48	G		7.590948e-05
CACNG1	786	broad.mit.edu	37	chr17	65041001	65041001	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcgggcccatcaccctgccCgggggtaacgtacccaccct	11	18	1	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr17:65041001C>T	uc002jfu.2	+	1	296	c.225C>T	c.(223-225)CCC>CCT	p.P75P		NM_000727	NP_000718	Q06432	CCG1_HUMAN	voltage-dependent calcium channel gamma-1	75					muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	TCACCCTGCCCGGGGGTAACG	0.637													T	65041001	T	T	65041001	2	4	71	1	0	0	0	0	0	0	0	1	2556	639	23	2		2	CACNG1	17	65041001	Silent	SNP	C	TCGA-06-0882-01A-01W-0424-08	18337463	65041001	16154209	41	4732											
KIF19	124602	broad.mit.edu	37	chr17	72345359	72345359	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaacgtctcctaccacatcGcccagtacaccagcatcatc	5	17	2	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr17:72345359G>A	uc002jkm.3	+	10	1222	c.1084G>A	c.(1084-1086)GCC>ACC	p.A362T	KIF19_uc002jkj.2_Missense_Mutation_p.A362T|KIF19_uc002jkk.2_Missense_Mutation_p.A320T|KIF19_uc002jkl.2_Missense_Mutation_p.A320T	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	362	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						CTACCACATCGCCCAGTACAC	0.642													A	72345359	A	A	72345359	3	1	71	1	0	0	0	0	1	0	0	0	8282	1087	38	1	1122	1	KIF19	17	72345359	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	7304358	72345359	8849851	42	4733											
LAMA1	284217	broad.mit.edu	37	chr18	6978310	6978310	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccccgccacgtccctcagCgtgctcaccgcgctctggct	10	20	3	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr18:6978310C>T	uc002knm.2	-	43	6169	c.6075G>A	c.(6073-6075)ACG>ACA	p.T2025T	LAMA1_uc010wzj.1_Silent_p.T1501T	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2025	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGTCCCTCAGCGTGCTCACCG	0.537													T	6978310	T	T	6978310	2	4	71	1	0	0	0	0	0	0	0	1	8605	755	27	1		1	LAMA1	18	6978310	Silent	SNP	C	TCGA-06-0882-01A-01W-0424-08		6978310	71098938	43	4734											
SETBP1	26040	broad.mit.edu	37	chr18	42530386	42530386	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggtcaagaatgcccagaaaGcatttgacaatacagaaggg	12	7	1	4	rs146321232		TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr18:42530386G>T	uc010dni.2	+	4	1377	c.1081G>T	c.(1081-1083)GCA>TCA	p.A361S		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	361						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TGCCCAGAAAGCATTTGACAA	0.478									Schinzel-Giedion_syndrome				T	42530386	T	T	42530386	3	4	71	1	0	0	0	0	1	0	0	0	14129	971	34	5	1284	5	SETBP1	18	42530386	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	35552076	42530386	35546862	44	4735											
ZNF254	9534	broad.mit.edu	37	chr19	24309636	24309636	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgaagcttttaatcgatcCtcaaatcttactacacataa	5	9	2	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr19:24309636C>T	uc002nru.2	+	4	968	c.834C>T	c.(832-834)TCC>TCT	p.S278S	ZNF254_uc010xrk.1_Silent_p.S193S	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	278	C2H2-type 3.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				TTAATCGATCCTCAAATCTTA	0.378													T	24309636	T	T	24309636	2	4	71	1	0	0	0	0	0	0	0	1	17795	668	24	3		3	ZNF254	19	24309636	Silent	SNP	C	TCGA-06-0882-01A-01W-0424-08		24309636	34819347	45	4736											
MEGF8	1954	broad.mit.edu	37	chr19	42861568	42861568	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccctcaggccccccagaccGtggagctgccagccgttgct	11	18	1	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr19:42861568G>A	uc002otl.3	+	27	5277	c.4642G>A	c.(4642-4644)GTG>ATG	p.V1548M	MEGF8_uc002otm.3_Missense_Mutation_p.V1156M	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1615	Extracellular (Potential).|Kelch 8.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				CCCCCAGACCGTGGAGCTGCC	0.652													A	42861568	A	A	42861568	3	1	71	1	0	0	0	0	1	0	0	0	9463	1145	40	1	4748	1	MEGF8	19	42861568	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	18551932	42861568	16267415	46	4737											
DUXA	503835	broad.mit.edu	37	chr19	57669795	57669795	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatgccttgatgagagtgtgTaactgagaggcgctgtaggt	15	5	0	3			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr19:57669795T>C	uc002qoa.1	-	4	384	c.339A>G	c.(337-339)TTA>TTG	p.L113L		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	113	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		TGAGAGTGTGTAACTGAGAGG	0.488													C	57669795	C	C	57669795	2	2	71	1	0	0	0	0	0	0	0	1	4834	1635	57	4		4	DUXA	19	57669795	Silent	SNP	T	TCGA-06-0882-01A-01W-0424-08	14808227	57669795	1459188	47	4738											
TASP1	55617	broad.mit.edu	37	chr20	13514755	13514755	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgtggtccacaaccacagCgcctaccgtgtccaaagtgc	9	15	0	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr20:13514755C>T	uc002woi.2	-	9	826	c.709G>A	c.(709-711)GCT>ACT	p.A237T	TASP1_uc010zri.1_Intron|TASP1_uc002woh.2_Missense_Mutation_p.A214T|TASP1_uc010zrj.1_RNA	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	237					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0						ACAACCACAGCGCCTACCGTG	0.507													T	13514755	T	T	13514755	3	4	71	1	0	0	0	0	1	0	0	0	15586	768	27	1	577	1	TASP1	20	13514755	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08		13514755	49510765	48	4739											
REM1	28954	broad.mit.edu	37	chr20	30070268	30070268	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacaaggcagacttggcccGctgccgagaagtctctgtgg	13	12	1	2			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr20:30070268G>A	uc002wwa.2	+	4	886	c.602G>A	c.(601-603)CGC>CAC	p.R201H		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	201					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GACTTGGCCCGCTGCCGAGAA	0.612													A	30070268	A	A	30070268	3	1	71	1	0	0	0	0	1	0	0	0	13222	1087	38	1	612	1	REM1	20	30070268	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08	16555513	30070268	32955252	49	4740											
TRPM2	7226	broad.mit.edu	37	chr21	45826547	45826547	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttcggggtggccaagcaggCcatcctcatccacaacgagc	11	15	1	0			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chr21:45826547C>A	uc002zet.1	+	20	3074	c.2861C>A	c.(2860-2862)GCC>GAC	p.A954D	TRPM2_uc002zeu.1_Missense_Mutation_p.A954D|TRPM2_uc002zew.1_Missense_Mutation_p.A954D|TRPM2_uc010gpt.1_Missense_Mutation_p.A954D|TRPM2_uc002zex.1_Missense_Mutation_p.A740D|TRPM2_uc002zey.1_Missense_Mutation_p.A467D	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	954	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCCAAGCAGGCCATCCTCATC	0.607													A	45826547	A	A	45826547	3	1	71	1	0	0	0	0	1	0	0	0	16583	739	26	5	2935	5	TRPM2	21	45826547	Missense_Mutation	SNP	C	TCGA-06-0882-01A-01W-0424-08		45826547	2303348	50	4741											
MID2	11043	broad.mit.edu	37	chrX	107160914	107160914	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	agttggggcctgtggccagaGataaggaaatgtaaggaagc	16	5	0	1			TCGA-06-0882-01A-01W-0424-08	TCGA-06-0882-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	385a3692-3208-479f-9f39-37fb65501b80	4ed08351-1e32-42e5-b009-e2f723cedfc5	g.chrX:107160914G>T	uc004enl.2	+	7	1953	c.1380G>T	c.(1378-1380)GAG>GAT	p.E460D	MID2_uc004enk.2_Intron	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	460	Fibronectin type-III.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TGTGGCCAGAGATAAGGAAAT	0.468													T	107160914	T	T	107160914	3	4	71	1	0	0	0	0	1	0	0	0	9578	933	33	5	1406	5	MID2	23	107160914	Missense_Mutation	SNP	G	TCGA-06-0882-01A-01W-0424-08		107160914	48109646	51	4742											
FBXO44	93611	broad.mit.edu	37	chr1	11716011	11716011	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagcctctggcgggaccTcatcgacctcgtgaccctct	10	17	3	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:11716011T>C	uc001asm.2	+	2	245	c.119T>C	c.(118-120)CTC>CCC	p.L40P	FBXO2_uc001asj.2_5'Flank|FBXO2_uc009vna.2_5'Flank|FBXO2_uc009vnb.1_5'Flank|FBXO44_uc001ask.2_Missense_Mutation_p.L40P|FBXO44_uc010oaq.1_Missense_Mutation_p.L40P|FBXO44_uc001asl.2_Missense_Mutation_p.L40P|FBXO44_uc001asn.2_Missense_Mutation_p.L40P|FBXO44_uc010oar.1_Missense_Mutation_p.L40P|FBXO44_uc010oas.1_5'UTR	NM_033182	NP_149438	Q9H4M3	FBX44_HUMAN	F-box protein 44 isoform 1	40	F-box.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCGGGACCTCATCGACCTC	0.632													C	11716011	C	C	11716011	3	2	72	1	0	0	0	0	1	0	0	0	5753	1551	54	4	121	4	FBXO44	1	11716011	Missense_Mutation	SNP	T	TCGA-06-0939-01A-01D-1353-08		11716011	237534610	1	4743											
NFIA	4774	broad.mit.edu	37	chr1	61869812	61869812	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accatcgactcttcatttccCgacatcacccattatccagc	3	17	3	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:61869812C>T	uc001czw.2	+	8	1596	c.1112C>T	c.(1111-1113)CCG>CTG	p.P371L	NFIA_uc001czy.2_Missense_Mutation_p.P363L|NFIA_uc010oos.1_Missense_Mutation_p.P416L|NFIA_uc001czv.2_Missense_Mutation_p.P371L|NFIA_uc001czx.2_Missense_Mutation_p.P19L|NFIA_uc009wae.2_5'Flank	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	371					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						CTTCATTTCCCGACATCACCC	0.493													T	61869812	T	T	61869812	3	4	72	1	0	0	0	0	1	0	0	0	10370	652	23	2	1288	2	NFIA	1	61869812	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	50153801	61869812	187380809	2	4744											
LRRC8C	84230	broad.mit.edu	37	chr1	90178321	90178321	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agagtgcagcctgctcagaaCcactcttccctttcgaatgt	8	13	2	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:90178321C>A	uc001dnl.3	+	3	434	c.192C>A	c.(190-192)AAC>AAA	p.N64K		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	64						endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		CTGCTCAGAACCACTCTTCCC	0.433													A	90178321	A	A	90178321	3	1	72	1	0	0	0	0	1	0	0	0	9023	506	18	5	198	5	LRRC8C	1	90178321	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	28308509	90178321	159072300	3	4745											
FLG	2312	broad.mit.edu	37	chr1	152287099	152287099	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gtaaattctcttttctggtaGactcataatatgcttgagcc	7	8	3	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:152287099G>T	uc001ezu.1	-	3	299	c.263C>A	c.(262-264)TCT>TAT	p.S88Y	uc001ezv.2_Splice_Site	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	88					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTTCTGGTAGACTCATAATA	0.358									Ichthyosis				T	152287099	T	T	152287099	3	4	72	1	0	0	0	0	1	0	0	0	5922	942	33	5	11926	5	FLG	1	152287099	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	62108778	152287099	96963522	4	4746											
PBXIP1	57326	broad.mit.edu	37	chr1	154918742	154918742	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcctttccactccactcccTagaattctggaagtgggact	7	13	1	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:154918742T>G	uc001ffr.2	-	10	1467	c.1408A>C	c.(1408-1410)AGG>CGG	p.R470R	PBXIP1_uc001ffs.2_Silent_p.R441R|PBXIP1_uc010pep.1_Silent_p.R315R	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	470					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTCCACTCCCTAGAATTCTGG	0.567													G	154918742	G	G	154918742	2	3	72	1	0	0	0	0	0	0	0	1	11496	1521	53	5		5	PBXIP1	1	154918742	Silent	SNP	T	TCGA-06-0939-01A-01D-1353-08	2631643	154918742	94331879	5	4747											
SPTA1	6708	broad.mit.edu	37	chr1	158615169	158615169	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgcctccatgtcagcacGgtgctcctgtgggaaaaagg	12	12	2	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:158615169G>A	uc001fst.1	-	29	4202	c.4003C>T	c.(4003-4005)CGT>TGT	p.R1335C		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1335	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ATGTCAGCACGGTGCTCCTGT	0.488													A	158615169	A	A	158615169	3	1	72	1	0	0	0	0	1	0	0	0	15115	1116	39	2	3352	2	SPTA1	1	158615169	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	3696427	158615169	90635452	6	4748											
DCAF8	50717	broad.mit.edu	37	chr1	160250017	160250017	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggtagagattcccgatgaCtctgcaaccattctggatac	10	10	2	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:160250017C>T	uc010pjc.1	-	4	445	c.173G>A	c.(172-174)AGT>AAT	p.S58N	PEX19_uc010pje.1_RNA|PEX19_uc001fvs.2_Missense_Mutation_p.S205N|PEX19_uc001fvt.2_Missense_Mutation_p.S115N	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	142						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						TTCCCGATGACTCTGCAACCA	0.418													T	160250017	T	T	160250017	3	4	72	1	0	0	0	0	1	0	0	0	4276	565	20	3		3	DCAF8	1	160250017	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	1634848	160250017	89000604	7	4749											
PAPPA2	60676	broad.mit.edu	37	chr1	176563773	176563773	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcttcttctccctctgcaccGaccgcgtgaagaaagccacc	7	17	4	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:176563773G>A	uc001gkz.2	+	3	2197	c.1033G>A	c.(1033-1035)GAC>AAC	p.D345N	PAPPA2_uc001gky.1_Missense_Mutation_p.D345N|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	345					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCTCTGCACCGACCGCGTGAA	0.592													A	176563773	A	A	176563773	3	1	72	1	0	0	0	0	1	0	0	0	11433	1058	37	2	1039	2	PAPPA2	1	176563773	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	16313756	176563773	72686848	8	4750											
ABL2	27	broad.mit.edu	37	chr1	179090932	179090932	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtaatgttgtcaccagcccaTcagccactgtggagtgatgg	12	10	2	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:179090932T>C	uc001gmj.3	-	5	1045	c.758A>G	c.(757-759)GAT>GGT	p.D253G	ABL2_uc010pnf.1_Missense_Mutation_p.D253G|ABL2_uc010png.1_Missense_Mutation_p.D232G|ABL2_uc010pnh.1_Missense_Mutation_p.D232G|ABL2_uc009wxe.2_Missense_Mutation_p.D232G|ABL2_uc001gmg.3_Missense_Mutation_p.D238G|ABL2_uc001gmi.3_Missense_Mutation_p.D238G|ABL2_uc001gmh.3_Missense_Mutation_p.D217G|ABL2_uc010pne.1_Missense_Mutation_p.D217G|ABL2_uc009wxf.1_Missense_Mutation_p.D238G|ABL2_uc001gmk.2_Missense_Mutation_p.D217G	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	253	SH2.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CACCAGCCCATCAGCCACTGT	0.498			T	ETV6	AML								C	179090932	C	C	179090932	3	2	72	1	0	0	0	0	1	0	0	0	93	1435	50	4	2867	4	ABL2	1	179090932	Missense_Mutation	SNP	T	TCGA-06-0939-01A-01D-1353-08	2527159	179090932	70159689	9	4751											
IL10	3586	broad.mit.edu	37	chr1	206942020	206942020	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcatgtaggcttctatgtaGttgatgaagatgtcaaactc	10	6	3	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:206942020G>A	uc001hen.1	-	5	557	c.498C>T	c.(496-498)AAC>AAT	p.N166N		NM_000572	NP_000563	P22301	IL10_HUMAN	interleukin 10 precursor	166					anti-apoptosis|B cell differentiation|B cell proliferation|cytoplasmic sequestering of NF-kappaB|inflammatory response|leukocyte chemotaxis|negative regulation of B cell proliferation|negative regulation of cytokine secretion involved in immune response|negative regulation of interferon-alpha biosynthetic process|negative regulation of interleukin-6 production|negative regulation of membrane protein ectodomain proteolysis|negative regulation of MHC class II biosynthetic process|negative regulation of T cell proliferation|positive regulation of B cell apoptosis|positive regulation of cytokine secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|receptor biosynthetic process|regulation of isotype switching|response to glucocorticoid stimulus|type 2 immune response	extracellular space	cytokine activity|growth factor activity|interleukin-10 receptor binding				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			CTTCTATGTAGTTGATGAAGA	0.413													A	206942020	A	A	206942020	2	1	72	1	0	0	0	0	0	0	0	1	7619	1020	36	3		3	IL10	1	206942020	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	27851088	206942020	42308601	10	4752											
CD46	4179	broad.mit.edu	37	chr1	207930974	207930974	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttggttatcagatgcactttAtttgtaatgaggggtaagtt	11	3	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:207930974A>G	uc001hgc.2	+	3	532	c.376A>G	c.(376-378)ATT>GTT	p.I126V	CD46_uc001hgd.2_Missense_Mutation_p.I126V|CD46_uc001hge.2_Missense_Mutation_p.I126V|CD46_uc001hgf.2_Missense_Mutation_p.I126V|CD46_uc001hgg.2_Missense_Mutation_p.I126V|CD46_uc001hgh.2_Missense_Mutation_p.I126V|CD46_uc001hgi.2_Missense_Mutation_p.I126V|CD46_uc001hgj.2_Missense_Mutation_p.I126V|CD46_uc001hgk.2_Missense_Mutation_p.I126V|CD46_uc001hgl.2_Missense_Mutation_p.I126V|CD46_uc001hgm.2_Missense_Mutation_p.I126V|CD46_uc001hgn.2_Missense_Mutation_p.I126V|CD46_uc001hgo.2_Missense_Mutation_p.I126V|CD46_uc001hgp.2_Missense_Mutation_p.I126V	NM_002389	NP_002380	P15529	MCP_HUMAN	CD46 antigen, complement regulatory protein	126	Extracellular (Potential).|Sushi 2.				complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			large_intestine(2)|lung(1)|central_nervous_system(1)	4						GATGCACTTTATTTGTAATGA	0.363													G	207930974	G	G	207930974	3	3	72	1	0	0	0	0	1	0	0	0	3018	449	16	4	386	4	CD46	1	207930974	Missense_Mutation	SNP	A	TCGA-06-0939-01A-01D-1353-08	988954	207930974	41319647	11	4753											
CD46	4179	broad.mit.edu	37	chr1	207934671	207934671	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tagaagtatttgagtatcttGatgcagtaacttatagttgt	9	3	1	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr1:207934671G>T	uc001hgc.2	+	5	709	c.553G>T	c.(553-555)GAT>TAT	p.D185Y	CD46_uc001hgd.2_Missense_Mutation_p.D185Y|CD46_uc001hge.2_Missense_Mutation_p.D185Y|CD46_uc001hgf.2_Missense_Mutation_p.D185Y|CD46_uc001hgg.2_Missense_Mutation_p.D185Y|CD46_uc001hgh.2_Missense_Mutation_p.D185Y|CD46_uc001hgi.2_Missense_Mutation_p.D185Y|CD46_uc001hgj.2_Missense_Mutation_p.D185Y|CD46_uc001hgk.2_Missense_Mutation_p.D185Y|CD46_uc001hgl.2_Missense_Mutation_p.D185Y|CD46_uc001hgm.2_Missense_Mutation_p.D185Y|CD46_uc001hgn.2_Missense_Mutation_p.D185Y|CD46_uc001hgo.2_Missense_Mutation_p.D185Y|CD46_uc001hgp.2_Missense_Mutation_p.D185Y	NM_002389	NP_002380	P15529	MCP_HUMAN	CD46 antigen, complement regulatory protein	185	Extracellular (Potential).|Sushi 3.				complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			large_intestine(2)|lung(1)|central_nervous_system(1)	4						TGAGTATCTTGATGCAGTAAC	0.373													T	207934671	T	T	207934671	3	4	72	1	0	0	0	0	1	0	0	0	3018	1290	45	5	571	5	CD46	1	207934671	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	3697	207934671	41315950	12	4754											
PSD4	23550	broad.mit.edu	37	chr2	113940279	113940279	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggagctgggtccatcaggaCgggctggagccttgccagga	18	10	1	0	rs147089589		TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr2:113940279C>T	uc002tjc.2	+	2	429	c.246C>T	c.(244-246)GAC>GAT	p.D82D	PSD4_uc002tjd.2_Translation_Start_Site|PSD4_uc002tje.2_Silent_p.D81D|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	82					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TCCATCAGGACGGGCTGGAGC	0.622													T	113940279	T	T	113940279	2	4	72	1	0	0	0	0	0	0	0	1	12649	535	19	1		1	PSD4	2	113940279	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08		113940279	129259094	13	4755											
MGAT5	4249	broad.mit.edu	37	chr2	135107438	135107438	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttaatcatgcaaattatgCccaatcgaaaggccacaaga	6	9	1	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr2:135107438C>T	uc002ttv.1	+	9	1320	c.1175C>T	c.(1174-1176)GCC>GTC	p.A392V		NM_002410	NP_002401	Q09328	MGT5A_HUMAN	N-acetylglucosaminyltransferase V	392	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0964)		GCAAATTATGCCCAATCGAAA	0.413													T	135107438	T	T	135107438	3	4	72	1	0	0	0	0	1	0	0	0	9548	739	26	3	1209	3	MGAT5	2	135107438	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	21167159	135107438	108091935	14	4756											
XIRP2	129446	broad.mit.edu	37	chr2	168107813	168107813	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaggttgcagtgcctcctcGcctgtcagagcacacacaga	10	14	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr2:168107813G>A	uc002udx.2	+	8	9929	c.9911G>A	c.(9910-9912)CGC>CAC	p.R3304H	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R3129H|XIRP2_uc010fpq.2_Missense_Mutation_p.R3082H|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3129					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTGCCTCCTCGCCTGTCAGAG	0.438													A	168107813	A	A	168107813	3	1	72	1	0	0	0	0	1	0	0	0	17427	1087	38	1	9941	1	XIRP2	2	168107813	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	33000375	168107813	75091560	15	4757											
LRP2	4036	broad.mit.edu	37	chr2	170134318	170134318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagagtcaacccagtaaacaCgcttcgatatcatatccaga	7	11	2	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr2:170134318C>T	uc002ues.2	-	13	1922	c.1709G>A	c.(1708-1710)CGT>CAT	p.R570H	LRP2_uc010zdf.1_Intron	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	570	LDL-receptor class B 4.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCAGTAAACACGCTTCGATAT	0.408													T	170134318	T	T	170134318	3	4	72	1	0	0	0	0	1	0	0	0	8956	536	19	1	12526	1	LRP2	2	170134318	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	2026505	170134318	73065055	16	4758											
TTN	7273	broad.mit.edu	37	chr2	179399105	179399108	+	Frame_Shift_Del	DEL	TCTT	-	-													ctgataactttagtactgacTctttctatcttctgcttcaa							TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr2:179399105_179399108delTCTT	uc010zfg.1	-	307	94754_94757	c.94530_94533delAAGA	c.(94528-94533)GAAAGAfs	p.E31510fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Del_p.E25205fs|TTN_uc010zfi.1_Frame_Shift_Del_p.E25138fs|TTN_uc010zfj.1_Frame_Shift_Del_p.E25013fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32437_32438							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGTACTGACTCTTTCTATCTTCT	0.461													-	179399108	-	-	179399105	7	5	72	1	0	1	0	1	0	0	0	0	16732	1548	54	0	5762	0	TTN	2	179399105	Frame_Shift_Del	DEL	TCTT	TCGA-06-0939-01A-01D-1353-08	9264787	179399105	63800268	17	4759											
TTN	7273	broad.mit.edu	37	chr2	179544077	179544077	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggatgtaccttttgctggcGgaggcttctcctttttagga	12	8	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr2:179544077G>A	uc010zfg.1	-	139	30223	c.29999C>T	c.(29998-30000)CCG>CTG	p.P10000L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6661L|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10927							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTGCTGGCGGAGGCTTCTC	0.413													A	179544077	A	A	179544077	3	1	72	1	0	0	0	0	1	0	0	0	16732	1116	39	2	70682	2	TTN	2	179544077	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	144972	179544077	63655296	18	4760											
SDPR	8436	broad.mit.edu	37	chr2	192711596	192711596	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctcgagggcttttcctgcCgcatgtcagacccagggtgc	14	13	1	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr2:192711596C>T	uc002utb.2	-	1	386	c.56G>A	c.(55-57)CGG>CAG	p.R19Q		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	19						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CTTTTCCTGCCGCATGTCAGA	0.607													T	192711596	T	T	192711596	3	4	72	1	0	0	0	0	1	0	0	0	13970	652	23	2	1229	2	SDPR	2	192711596	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	13167519	192711596	50487777	19	4761											
NGEF	25791	broad.mit.edu	37	chr2	233744299	233744299	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aacattccttgaggttctggGaccggatcttgggattcaag	12	8	3	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr2:233744299G>T	uc002vts.2	-	15	2281	c.2033C>A	c.(2032-2034)TCC>TAC	p.S678Y	NGEF_uc010zmm.1_Missense_Mutation_p.S401Y|NGEF_uc010fyg.1_Missense_Mutation_p.S586Y	NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	678					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GAGGTTCTGGGACCGGATCTT	0.582													T	233744299	T	T	233744299	3	4	72	1	0	0	0	0	1	0	0	0	10394	1174	41	5	103	5	NGEF	2	233744299	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	41032703	233744299	9455074	20	4762											
PPARG	5468	broad.mit.edu	37	chr3	12447429	12447429	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgagaaggagaagctgttggCggagatctccagtgatatcg	15	7	1	4			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr3:12447429C>T	uc003bwx.2	+	5	759	c.668C>T	c.(667-669)GCG>GTG	p.A223V	PPARG_uc003bwr.2_Missense_Mutation_p.A195V|PPARG_uc003bws.2_Missense_Mutation_p.A195V|PPARG_uc003bwu.2_Missense_Mutation_p.A195V|PPARG_uc003bwv.2_Missense_Mutation_p.A195V|PPARG_uc010hea.1_RNA|PPARG_uc003bwq.1_Missense_Mutation_p.A195V|PPARG_uc003bwt.1_Missense_Mutation_p.A195V|PPARG_uc003bww.1_Missense_Mutation_p.A223V	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	223	Interaction with FAM120B (By similarity).				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	AAGCTGTTGGCGGAGATCTCC	0.512			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						T	12447429	T	T	12447429	3	4	72	1	0	0	0	0	1	0	0	0	12299	768	27	1	686	1	PPARG	3	12447429	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08		12447429	185575001	21	4763											
C3orf72	401089	broad.mit.edu	37	chr3	138669148	138669148	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggcagaagccgcccgcgcctCgggcttccggcggcccagct	15	18	0	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr3:138669148C>T	uc003esx.1	+	3	393	c.262C>T	c.(262-264)CGG>TGG	p.R88W	C3orf72_uc011bmr.1_3'UTR	NM_001040061	NP_001035150	Q6ZUU3	CC072_HUMAN	chromosome 3 open reading frame 72	88											0						GCCCGCGCCTCGGGCTTCCGG	0.692													T	138669148	T	T	138669148	3	4	72	1	0	0	0	0	1	0	0	0	2244	875	31	2	272	2	C3orf72	3	138669148	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	126221719	138669148	59353282	22	4764											
SUCNR1	56670	broad.mit.edu	37	chr3	151598459	151598459	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggagtccttggaaataccaTtgttgtttacggctacatct	10	8	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr3:151598459T>C	uc003ezf.1	+	3	227	c.128T>C	c.(127-129)ATT>ACT	p.I43T		NM_033050	NP_149039	Q9BXA5	SUCR1_HUMAN	succinate receptor 1	43	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	GGAAATACCATTGTTGTTTAC	0.433													C	151598459	C	C	151598459	3	2	72	1	0	0	0	0	1	0	0	0	15365	1493	52	4	134	4	SUCNR1	3	151598459	Missense_Mutation	SNP	T	TCGA-06-0939-01A-01D-1353-08	12929311	151598459	46423971	23	4765											
ZNF732	654254	broad.mit.edu	37	chr4	266352	266352	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttctcatatcttcttaatatAagtttgtggaacgaatcttc	5	7	4	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr4:266352A>G	uc011buu.1	-	3	305	c.291T>C	c.(289-291)CTT>CTC	p.L97L	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	98					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCTTAATATAAGTTTGTGGA	0.328													G	266352	G	G	266352	2	3	72	1	0	0	0	0	0	0	0	1	18120	349	13	4		4	ZNF732	4	266352	Silent	SNP	A	TCGA-06-0939-01A-01D-1353-08		266352	190887924	24	4766											
WDR19	57728	broad.mit.edu	37	chr4	39267694	39267694	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attaaacaggttggtcaggcCaaagatgaactgctgaccaa	10	8	1	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr4:39267694C>T	uc003gtv.2	+	29	3349	c.3195C>T	c.(3193-3195)GCC>GCT	p.A1065A	WDR19_uc011byi.1_Silent_p.A905A|WDR19_uc003gtw.1_Silent_p.A662A	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1065					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TTGGTCAGGCCAAAGATGAAC	0.473													T	39267694	T	T	39267694	2	4	72	1	0	0	0	0	0	0	0	1	17276	581	21	3		3	WDR19	4	39267694	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	39001342	39267694	151886582	25	4767											
GUCY1B3	2983	broad.mit.edu	37	chr4	156721201	156721201	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agctcacgttaagagccctgGaagatgaaaagaaaaagaca	10	7	1	5			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr4:156721201G>T	uc003ipc.2	+	9	1317	c.1150G>T	c.(1150-1152)GAA>TAA	p.E384*	GUCY1B3_uc011cio.1_Nonsense_Mutation_p.E406*|GUCY1B3_uc011cip.1_Nonsense_Mutation_p.E364*|GUCY1B3_uc003ipd.2_Nonsense_Mutation_p.E312*|GUCY1B3_uc010iqf.2_Nonsense_Mutation_p.E384*|GUCY1B3_uc010iqg.2_Nonsense_Mutation_p.E312*|GUCY1B3_uc011ciq.1_Nonsense_Mutation_p.E312*	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	384					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AAGAGCCCTGGAAGATGAAAA	0.393													T	156721201	T	T	156721201	4	4	72	1	0	0	0	0	0	1	0	0	6895	1175	41	5	1184	5	GUCY1B3	4	156721201	Nonsense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	117453507	156721201	34433075	26	4768											
KIAA0947	23379	broad.mit.edu	37	chr5	5464090	5464090	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttataactcaaaactagagcCatctggcaaaaataagaatc	5	8	2	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr5:5464090C>G	uc003jdm.3	+	13	4865	c.4643C>G	c.(4642-4644)CCA>CGA	p.P1548R		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1548										ovary(1)|central_nervous_system(1)	2						AAACTAGAGCCATCTGGCAAA	0.358													G	5464090	G	G	5464090	3	3	72	1	0	0	0	0	1	0	0	0	8202	594	21	5	4693	5	KIAA0947	5	5464090	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08		5464090	175451170	27	4769											
BDP1	55814	broad.mit.edu	37	chr5	70806902	70806902	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgagctagaggagaccagtaCctcaagacaaactgacacac	9	12	1	4			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr5:70806902C>A	uc003kbp.1	+	17	4246	c.3983C>A	c.(3982-3984)ACC>AAC	p.T1328N	BDP1_uc003kbn.1_Missense_Mutation_p.T1328N|BDP1_uc003kbo.2_Missense_Mutation_p.T1328N	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1328					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GAGACCAGTACCTCAAGACAA	0.408													A	70806902	A	A	70806902	3	1	72	1	0	0	0	0	1	0	0	0	1395	507	18	5	4049	5	BDP1	5	70806902	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	65342812	70806902	110108358	28	4770											
SV2C	22987	broad.mit.edu	37	chr5	75428010	75428010	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagctgataatccaagaatgCggtcatggtcgttttcagtg	12	7	2	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr5:75428010C>T	uc003kei.1	+	2	569	c.435C>T	c.(433-435)TGC>TGT	p.C145C		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	145	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TCCAAGAATGCGGTCATGGTC	0.537													T	75428010	T	T	75428010	2	4	72	1	0	0	0	0	0	0	0	1	15416	776	27	1		1	SV2C	5	75428010	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	4621108	75428010	105487250	29	4771											
FAM81B	153643	broad.mit.edu	37	chr5	94749868	94749868	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagaccatcaccagcatcGtcaaaaaactcagccaaaat	4	14	3	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr5:94749868G>A	uc003kla.1	+	4	557	c.511G>A	c.(511-513)GTC>ATC	p.V171I	FAM81B_uc010jbe.1_5'UTR	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	171	Potential.									ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		CACCAGCATCGTCAAAAAACT	0.418													A	94749868	A	A	94749868	3	1	72	1	0	0	0	0	1	0	0	0	5629	1145	40	1	525	1	FAM81B	5	94749868	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	19321858	94749868	86165392	30	4772											
PCDHA1	56147	broad.mit.edu	37	chr5	140166149	140166149	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgtgaattctcggatcgatCgcgaggagctgtgccagtgg	15	8	1	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr5:140166149C>T	uc003lhb.2	+	1	274	c.274C>T	c.(274-276)CGC>TGC	p.R92C	PCDHA1_uc003lha.2_Missense_Mutation_p.R92C|PCDHA1_uc003lgz.2_Missense_Mutation_p.R92C	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGATCGATCGCGAGGAGCT	0.567													T	140166149	T	T	140166149	3	4	72	1	0	0	0	0	1	0	0	0	11519	884	31	2	276	2	PCDHA1	5	140166149	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	45416281	140166149	40749111	31	4773											
MED7	9443	broad.mit.edu	37	chr5	156565766	156565766	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtctttcattcatctcatcaAttaggacacacaaggcagca	6	11	5	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr5:156565766A>G	uc010jik.2	-	2	1069	c.677T>C	c.(676-678)ATT>ACT	p.I226T	MED7_uc003lwm.3_Missense_Mutation_p.I226T	NM_001100816	NP_001094286	O43513	MED7_HUMAN	mediator complex subunit 7	226					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity				0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATCTCATCAATTAGGACACA	0.323													G	156565766	G	G	156565766	3	3	72	1	0	0	0	0	1	0	0	0	9452	101	4	4	28	4	MED7	5	156565766	Missense_Mutation	SNP	A	TCGA-06-0939-01A-01D-1353-08	16399617	156565766	24349494	32	4774											
ADAMTS2	9509	broad.mit.edu	37	chr5	178581109	178581109	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtggaagcggtggaaggcGgcctgcaccaggggcgccat	18	11	0	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr5:178581109G>A	uc003mjw.2	-	8	1323	c.1323C>T	c.(1321-1323)GCC>GCT	p.A441A	ADAMTS2_uc011dgm.1_Silent_p.A441A	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	441	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GGTGGAAGGCGGCCTGCACCA	0.711													A	178581109	A	A	178581109	2	1	72	1	0	0	0	0	0	0	0	1	265	1103	39	2		2	ADAMTS2	5	178581109	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	22015343	178581109	2334151	33	4775											
MUT	4594	broad.mit.edu	37	chr6	49419405	49419405	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccattgcttctattgcagtaCggacaatattattgtaggga	9	7	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr6:49419405C>T	uc003ozg.3	-	6	1361	c.1106G>A	c.(1105-1107)CGT>CAT	p.R369H		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	369			R -> H (in MMAM; mut- and mut0).|R -> C (in MMAM; mut0).		fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TATTGCAGTACGGACAATATT	0.348													T	49419405	T	T	49419405	3	4	72	1	0	0	0	0	1	0	0	0	9991	536	19	1	1178	1	MUT	6	49419405	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08		49419405	121695662	34	4776											
ZNF451	26036	broad.mit.edu	37	chr6	56963890	56963890	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgacctgttcttgaatacaTtgatctggtcagcagtgatg	10	8	3	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr6:56963890T>C	uc003pdm.1	+	3	361	c.137T>C	c.(136-138)ATT>ACT	p.I46T	ZNF451_uc003pdl.2_Missense_Mutation_p.I46T|ZNF451_uc003pdn.1_Missense_Mutation_p.I46T|ZNF451_uc011dxn.1_Missense_Mutation_p.I46T|ZNF451_uc003pdk.1_Missense_Mutation_p.I46T|ZNF451_uc003pdo.2_RNA|uc003pdp.2_5'Flank	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CTTGAATACATTGATCTGGTC	0.338													C	56963890	C	C	56963890	3	2	72	1	0	0	0	0	1	0	0	0	17919	1493	52	4	147	4	ZNF451	6	56963890	Missense_Mutation	SNP	T	TCGA-06-0939-01A-01D-1353-08	7544485	56963890	114151177	35	4777											
SIM1	6492	broad.mit.edu	37	chr6	100896122	100896122	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttcgtaccccgtcagctcCgccaccctgaggagagcaat	11	15	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr6:100896122C>T	uc003pqj.3	-	7	957	c.750G>A	c.(748-750)GCG>GCA	p.A250A	SIM1_uc010kcu.2_Silent_p.A250A	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	250	PAS 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CCGTCAGCTCCGCCACCCTGA	0.627													T	100896122	T	T	100896122	2	4	72	1	0	0	0	0	0	0	0	1	14323	639	23	2		2	SIM1	6	100896122	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	43932232	100896122	70218945	36	4778											
AIM1	202	broad.mit.edu	37	chr6	107008787	107008787	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgccaaataggttctctaCgaccttttgttcaggtattt	8	9	2	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr6:107008787C>T	uc003prh.2	+	17	5228	c.4741C>T	c.(4741-4743)CGA>TGA	p.R1581*	AIM1_uc003pri.2_Nonsense_Mutation_p.R385*	NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1581	Beta/gamma crystallin 'Greek key' 12.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGGTTCTCTACGACCTTTTGT	0.378													T	107008787	T	T	107008787	4	4	72	1	0	0	0	0	0	1	0	0	430	528	19	1	4807	1	AIM1	6	107008787	Nonsense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	6112665	107008787	64106280	37	4779											
HECA	51696	broad.mit.edu	37	chr6	139488187	139488187	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgtgcagttccttcggcgGctggacctctccgaactcct	10	17	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr6:139488187G>A	uc003qin.2	+	2	1323	c.1038G>A	c.(1036-1038)CGG>CGA	p.R346R		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	346					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		TCCTTCGGCGGCTGGACCTCT	0.597													A	139488187	A	A	139488187	2	1	72	1	0	0	0	0	0	0	0	1	7038	1190	42	3		3	HECA	6	139488187	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	32479400	139488187	31626880	38	4780											
SNX9	51429	broad.mit.edu	37	chr6	158357061	158357061	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atgaagaaattgccagtctcGtggcagaacaggtactaaca	10	8	1	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr6:158357061G>T	uc003qqv.1	+	14	1605	c.1432G>T	c.(1432-1434)GTG>TTG	p.V478L		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	478	BAR.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		TGCCAGTCTCGTGGCAGAACA	0.348													T	158357061	T	T	158357061	3	4	72	1	0	0	0	0	1	0	0	0	14909	1145	40	5	1486	5	SNX9	6	158357061	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	18868874	158357061	12758006	39	4781											
STK31	56164	broad.mit.edu	37	chr7	23827708	23827708	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtatttgctttaaaccgtgAacaaggaattgttggagatt	10	4	0	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr7:23827708A>G	uc003sws.3	+	21	2664	c.2597A>G	c.(2596-2598)GAA>GGA	p.E866G	STK31_uc003swt.3_Missense_Mutation_p.E843G|STK31_uc011jze.1_Missense_Mutation_p.E866G|STK31_uc010kuq.2_Missense_Mutation_p.E843G|STK31_uc003swv.1_Missense_Mutation_p.E32G	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	866	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TTAAACCGTGAACAAGGAATT	0.353													G	23827708	G	G	23827708	3	3	72	1	0	0	0	0	1	0	0	0	15295	246	9	4	2679	4	STK31	7	23827708	Missense_Mutation	SNP	A	TCGA-06-0939-01A-01D-1353-08		23827708	135310955	40	4782											
C7orf10	79783	broad.mit.edu	37	chr7	40356417	40356417	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtcaaaaggaagcaaaacGttggggtacagctcatggca	13	7	2	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr7:40356417G>A	uc003thn.1	+	9	824	c.779G>A	c.(778-780)CGT>CAT	p.R260H	C7orf10_uc003thm.1_Missense_Mutation_p.R230H|C7orf10_uc003tho.1_Missense_Mutation_p.R212H	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	267							transferase activity			ovary(2)	2						GAAGCAAAACGTTGGGGTACA	0.388													A	40356417	A	A	40356417	3	1	72	1	0	0	0	0	1	0	0	0	2376	1145	40	1	723	1	C7orf10	7	40356417	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	16528709	40356417	118782246	41	4783											
MUC17	140453	broad.mit.edu	37	chr7	100679249	100679249	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaggaagcactgcattaacaAgtatacctgtcagcaccaca	7	11	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr7:100679249A>G	uc003uxp.1	+	3	4605	c.4552A>G	c.(4552-4554)AGT>GGT	p.S1518G	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1518	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|23.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TGCATTAACAAGTATACCTGT	0.483													G	100679249	G	G	100679249	3	3	72	1	0	0	0	0	1	0	0	0	9974	72	3	4	4562	4	MUC17	7	100679249	Missense_Mutation	SNP	A	TCGA-06-0939-01A-01D-1353-08	60322832	100679249	58459414	42	4784											
KCNU1	157855	broad.mit.edu	37	chr8	36768588	36768588	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atcatggcaaccctcaccatCggatccttgcaaattgactc	6	14	2	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr8:36768588C>T	uc010lvw.2	+	22	2559	c.2472C>T	c.(2470-2472)ATC>ATT	p.I824I	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	824	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CCCTCACCATCGGATCCTTGC	0.512													T	36768588	T	T	36768588	2	4	72	1	0	0	0	0	0	0	0	1	8093	874	31	2		2	KCNU1	8	36768588	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08		36768588	109595434	43	4785											
ST18	9705	broad.mit.edu	37	chr8	53085003	53085003	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttacagtctgaacagataCatttttttcaaatttcccca	3	10	2	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr8:53085003C>T	uc003xqz.2	-	5	574	c.418G>A	c.(418-420)GTA>ATA	p.V140I	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.V105I|ST18_uc011lds.1_Missense_Mutation_p.V45I|ST18_uc003xra.2_Missense_Mutation_p.V140I|ST18_uc003xrb.2_Missense_Mutation_p.V140I	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	140						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGAACAGATACATTTTTTTCA	0.383													T	53085003	T	T	53085003	3	4	72	1	0	0	0	0	1	0	0	0	15211	478	17	3	2793	3	ST18	8	53085003	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	16316415	53085003	93279019	44	4786											
NSMAF	8439	broad.mit.edu	37	chr8	59548070	59548070	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatctggttcaaaaatcaccGattttgaacatatttttaag	5	6	3	1	rs35436008		TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr8:59548070G>A	uc003xtt.2	-	3	399	c.185C>T	c.(184-186)TCG>TTG	p.S62L	NSMAF_uc011lee.1_Missense_Mutation_p.S93L|NSMAF_uc003xtu.2_Missense_Mutation_p.S62L	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	62					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				AAAAATCACCGATTTTGAACA	0.323													A	59548070	A	A	59548070	3	1	72	1	0	0	0	0	1	0	0	0	10674	1059	37	2	2684	2	NSMAF	8	59548070	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	6463067	59548070	86815952	45	4787											
SLCO5A1	81796	broad.mit.edu	37	chr8	70744273	70744273	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagatgaagtgaggtaaggcGaagagggctgccccgaaggc	18	7	0	4			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr8:70744273G>A	uc003xyl.2	-	2	1343	c.636C>T	c.(634-636)TTC>TTT	p.F212F	SLCO5A1_uc010lzb.2_Silent_p.F212F|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Silent_p.F212F|SLCO5A1_uc010lzc.2_Silent_p.F212F	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	212	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GAGGTAAGGCGAAGAGGGCTG	0.662													A	70744273	A	A	70744273	2	1	72	1	0	0	0	0	0	0	0	1	14731	1049	37	2		2	SLCO5A1	8	70744273	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	11196203	70744273	75619749	46	4788											
ASAP1	50807	broad.mit.edu	37	chr8	131414154	131414154	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttccatagtgaatctctcgaCgaaaaactggagagcctgga	10	9	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr8:131414154C>A	uc003yta.1	-	1	64	c.36G>T	c.(34-36)TCG>TCT	p.S12S	ASAP1_uc011liw.1_5'UTR	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	12					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						AATCTCTCGACGAAAAACTGG	0.502													A	131414154	A	A	131414154	2	1	72	1	0	0	0	0	0	0	0	1	1010	523	19	5		5	ASAP1	8	131414154	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	60669881	131414154	14949868	47	4789											
SLC45A4	57210	broad.mit.edu	37	chr8	142231734	142231734	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggacgccaacgcagagggcGaggatgaagggccgccggcg	19	11	0	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr8:142231734G>A	uc003ywd.1	-	2	527	c.219C>T	c.(217-219)CTC>CTT	p.L73L	SLC45A4_uc003ywc.1_Silent_p.L73L|SLC45A4_uc010meq.1_Silent_p.L71L	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	124	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CGCAGAGGGCGAGGATGAAGG	0.612													A	142231734	A	A	142231734	2	1	72	1	0	0	0	0	0	0	0	1	14643	1045	37	2		2	SLC45A4	8	142231734	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	10817580	142231734	4132288	48	4790											
LRRC14	9684	broad.mit.edu	37	chr8	145746502	145746502	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttgcatctggagctgactgaGtgtcagctcgcagacaccca	11	12	2	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr8:145746502G>C	uc003zdk.1	+	4	1268	c.1122G>C	c.(1120-1122)GAG>GAC	p.E374D	LRRC14_uc003zdl.1_Missense_Mutation_p.E374D|LRRC14_uc003zdo.2_5'Flank	NM_014665	NP_055480	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	374	LRR 4.										0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			AGCTGACTGAGTGTCAGCTCG	0.597													C	145746502	C	C	145746502	3	2	72	1	0	0	0	0	1	0	0	0	8968	1020	36	5	1132	5	LRRC14	8	145746502	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	3514768	145746502	617520	49	4791											
GDA	9615	broad.mit.edu	37	chr9	74863239	74863239	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcggaaagcaggtggttcCgttttccagctcagtgtaag	15	8	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr9:74863239C>T	uc004aiq.2	+	14	1529	c.1346C>T	c.(1345-1347)CCG>CTG	p.P449L	GDA_uc011lse.1_Missense_Mutation_p.P375L|GDA_uc011lsf.1_Missense_Mutation_p.P375L|GDA_uc004air.2_Missense_Mutation_p.P449L|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Missense_Mutation_p.P371L	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	449					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		CAGGTGGTTCCGTTTTCCAGC	0.443													T	74863239	T	T	74863239	3	4	72	1	0	0	0	0	1	0	0	0	6306	652	23	2	1400	2	GDA	9	74863239	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08		74863239	66350192	50	4792											
OR13C3	138803	broad.mit.edu	37	chr9	107298585	107298585	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagaagccatcaatacataCgccaccttgctcaggatgat	7	12	2	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr9:107298585C>T	uc004bcb.1	-	1	510	c.510G>A	c.(508-510)GCG>GCA	p.A170A		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	170	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TCAATACATACGCCACCTTGC	0.468													T	107298585	T	T	107298585	2	4	72	1	0	0	0	0	0	0	0	1	10935	523	19	1		1	OR13C3	9	107298585	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	32435346	107298585	33914846	51	4793											
SVIL	6840	broad.mit.edu	37	chr10	29776136	29776136	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaactctcctacccacaggaAgcagcagtggggagagagca	12	11	1	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr10:29776136A>G	uc001iut.1	-	24	5194	c.4441T>C	c.(4441-4443)TTC>CTC	p.F1481L	LOC387647_uc001iuq.1_RNA|SVIL_uc010qdw.1_Missense_Mutation_p.F395L|SVIL_uc001iuu.1_Missense_Mutation_p.F1055L|SVIL_uc009xlc.2_Missense_Mutation_p.F273L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1481	Gelsolin-like 1.|Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				ACCCACAGGAAGCAGCAGTGG	0.517													G	29776136	G	G	29776136	3	3	72	1	0	0	0	0	1	0	0	0	15418	72	3	4	2263	4	SVIL	10	29776136	Missense_Mutation	SNP	A	TCGA-06-0939-01A-01D-1353-08		29776136	105758611	52	4794											
C10orf71	118461	broad.mit.edu	37	chr10	50532018	50532018	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacccccaggacagctaaaCggataccaagagaaggagcc	10	13	1	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr10:50532018C>T	uc010qgp.1	+	3	1767	c.1428C>T	c.(1426-1428)AAC>AAT	p.N476N		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	476											0						GACAGCTAAACGGATACCAAG	0.572													T	50532018	T	T	50532018	2	4	72	1	0	0	0	0	0	0	0	1	1614	535	19	1		1	C10orf71	10	50532018	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	20755882	50532018	85002729	53	4795											
PTEN	5728	broad.mit.edu	37	chr10	89717672	89717672	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctccaattcaggacccacaCgacgggaagacaagttcatg	9	13	2	1	rs121909219		TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr10:89717672C>T	uc001kfb.2	+	8	1728	c.697C>T	c.(697-699)CGA>TGA	p.R233*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R233*(61)|p.R233fs*10(4)|p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R233fs*25(1)|p.R233fs*23(1)|p.R233R(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGGACCCACACGACGGGAAGA	0.423	R233*(JHUEM1_ENDOMETRIUM)|R233*(SW1783_CENTRAL_NERVOUS_SYSTEM)|R233*(NCIH1155_LUNG)|R233*(SF295_CENTRAL_NERVOUS_SYSTEM)|R233*(HEC59_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89717672	T	T	89717672	4	4	72	1	0	0	0	0	0	1	0	0	12738	528	19	1	723	1	PTEN	10	89717672	Nonsense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	39185654	89717672	45817075	54	4796											
MICAL2	9645	broad.mit.edu	37	chr11	12244171	12244171	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cgcctccctccagggaaagtCtctaccggctgttacctcag	9	16	2	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr11:12244171C>A	uc001mjz.2	+	11	1618	c.1330C>A	c.(1330-1332)CTC>ATC	p.L444I	MICAL2_uc010rch.1_Missense_Mutation_p.L444I|MICAL2_uc001mka.2_Missense_Mutation_p.L444I|MICAL2_uc010rci.1_Missense_Mutation_p.L444I|MICAL2_uc001mkb.2_Missense_Mutation_p.L444I|MICAL2_uc001mkc.2_Missense_Mutation_p.L444I|MICAL2_uc001mkd.2_Missense_Mutation_p.L273I|MICAL2_uc010rcj.1_5'UTR	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	444						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		CAGGGAAAGTCTCTACCGGCT	0.567													A	12244171	A	A	12244171	3	1	72	1	0	0	0	0	1	0	0	0	9570	913	32	5	1364	5	MICAL2	11	12244171	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08		12244171	122762345	55	4797											
OR5M10	390167	broad.mit.edu	37	chr11	56344526	56344526	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcagaacggatcctgaagatCgctgcaaaaatgaaaagata	10	7	0	5			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr11:56344526C>T	uc001niz.1	-	1	672	c.672G>A	c.(670-672)GCG>GCA	p.A224A		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCTGAAGATCGCTGCAAAAA	0.443													T	56344526	T	T	56344526	2	4	72	1	0	0	0	0	0	0	0	1	11173	871	31	2		2	OR5M10	11	56344526	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	44100355	56344526	78661990	56	4798											
SLC22A10	387775	broad.mit.edu	37	chr11	63072232	63072232	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccctcttgatgaccttaaCggtattttttaccactttgc	5	12	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr11:63072232C>T	uc009yor.2	+	9	1677	c.1469C>T	c.(1468-1470)ACG>ATG	p.T490M	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_3'UTR	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	490	Helical; (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						ATGACCTTAACGGTATTTTTT	0.423													T	63072232	T	T	63072232	3	4	72	1	0	0	0	0	1	0	0	0	14441	536	19	1	1503	1	SLC22A10	11	63072232	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	6727706	63072232	71934284	57	4799											
GRM5	2915	broad.mit.edu	37	chr11	88242179	88242179	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cagcatcatggagttgagctCgctgatgttggccgtgaagc	14	9	1	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr11:88242179C>G	uc001pcq.2	-	9	3420	c.3220G>C	c.(3220-3222)GAG>CAG	p.E1074Q	GRM5_uc009yvm.2_Missense_Mutation_p.E1042Q	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	1074	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GAGTTGAGCTCGCTGATGTTG	0.667													G	88242179	G	G	88242179	3	3	72	1	0	0	0	0	1	0	0	0	6800	893	31	5	422	5	GRM5	11	88242179	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	25169947	88242179	46764337	58	4800											
MAML2	84441	broad.mit.edu	37	chr11	96075000	96075000	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gagccccctccaaggagcccCgccccagaggccccccctag	10	22	0	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr11:96075000C>G	uc001pfw.1	-	1	1345	c.60G>C	c.(58-60)GCG>GCC	p.A20A		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	20					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CAAGGAGCCCCGCCCCAGAGG	0.682			T	MECT1|CRTC3	salivary gland mucoepidermoid						OREG0021305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	96075000	G	G	96075000	2	3	72	1	0	0	0	0	0	0	0	1	9206	639	23	5		5	MAML2	11	96075000	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	7832821	96075000	38931516	59	4801											
PGR	5241	broad.mit.edu	37	chr11	100996783	100996783	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttacagctcccacaggtaaGgacaccataatgacagcctg	8	13	0	1	rs144880156		TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr11:100996783G>A	uc001pgh.2	-	2	2487	c.1744C>T	c.(1744-1746)CTT>TTT	p.L582F	PGR_uc001pgi.2_Missense_Mutation_p.L582F|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	582	NR C4-type.|Nuclear receptor.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CCACAGGTAAGGACACCATAA	0.443													A	100996783	A	A	100996783	3	1	72	1	0	0	0	0	1	0	0	0	11805	1000	35	3	1085	3	PGR	11	100996783	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	4921783	100996783	34009733	60	4802											
ELMOD1	55531	broad.mit.edu	37	chr11	107501263	107501263	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctgttataataccaagccGggagcttctagaaccatgaa	8	9	2	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr11:107501263G>A	uc010rvs.1	+	3	542	c.138G>A	c.(136-138)CCG>CCA	p.P46P	ELMOD1_uc001pjm.2_Silent_p.P46P|ELMOD1_uc010rvt.1_Silent_p.P40P	NM_018712	NP_061182	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1 isoform 1	46					phagocytosis	cytoskeleton	GTPase activator activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		ATACCAAGCCGGGAGCTTCTA	0.398													A	107501263	A	A	107501263	2	1	72	1	0	0	0	0	0	0	0	1	5068	1103	39	2		2	ELMOD1	11	107501263	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	6504480	107501263	27505253	61	4803											
C11orf65	160140	broad.mit.edu	37	chr11	108302504	108302504	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taatatatttcactatctgaCgtggttctccttgtcttctt	5	9	5	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr11:108302504C>T	uc001pkh.2	-	3	213	c.143G>A	c.(142-144)CGT>CAT	p.R48H	C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_RNA	NM_152587	NP_689800	Q8NCR3	CK065_HUMAN	hypothetical protein LOC160140	48										ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		CACTATCTGACGTGGTTCTCC	0.303													T	108302504	T	T	108302504	3	4	72	1	0	0	0	0	1	0	0	0	1655	536	19	1	826	1	C11orf65	11	108302504	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	801241	108302504	26704012	62	4804											
NTF3	4908	broad.mit.edu	37	chr12	5603799	5603799	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcacggcggaaacggtacgCggagcataagagtcaccgag	14	10	2	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr12:5603799C>T	uc001qnl.3	+	1	502	c.419C>T	c.(418-420)GCG>GTG	p.A140V	NTF3_uc001qnk.3_Missense_Mutation_p.A153V	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	140					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						AAACGGTACGCGGAGCATAAG	0.602													T	5603799	T	T	5603799	3	4	72	1	0	0	0	0	1	0	0	0	10696	768	27	1	464	1	NTF3	12	5603799	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08		5603799	128248096	63	4805											
LEPREL2	10536	broad.mit.edu	37	chr12	6946946	6946946	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acccagtgcacgcagacaacTgcgtcctggaccctgacacg	10	16	0	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr12:6946946T>A	uc001qra.1	+	14	1796	c.1762T>A	c.(1762-1764)TGC>AGC	p.C588S	LEPREL2_uc001qqz.1_Missense_Mutation_p.C395S|LEPREL2_uc001qrb.1_Missense_Mutation_p.C395S|GNB3_uc001qrc.2_5'Flank|GNB3_uc001qrd.2_5'Flank	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	588	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CGCAGACAACTGCGTCCTGGA	0.642													A	6946946	A	A	6946946	3	1	72	1	0	0	0	0	1	0	0	0	8731	1580	55	5	1807	5	LEPREL2	12	6946946	Missense_Mutation	SNP	T	TCGA-06-0939-01A-01D-1353-08	1343147	6946946	126904949	64	4806											
CCDC91	55297	broad.mit.edu	37	chr12	28459762	28459762	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtaatggaacaattgcccttGtggatgattctgaggatcct	11	7	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr12:28459762G>A	uc001riq.2	+	4	371	c.355G>A	c.(355-357)GTG>ATG	p.V119M	CCDC91_uc001rio.2_Missense_Mutation_p.V89M|CCDC91_uc009zjk.2_RNA|CCDC91_uc001rip.1_Missense_Mutation_p.V119M|CCDC91_uc001rir.2_Translation_Start_Site|CCDC91_uc009zjl.2_Translation_Start_Site	NM_018318	NP_060788	Q7Z6B0	CCD91_HUMAN	GGA binding partner	119					protein transport	Golgi apparatus|membrane				central_nervous_system(1)	1	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					AATTGCCCTTGTGGATGATTC	0.358													A	28459762	A	A	28459762	3	1	72	1	0	0	0	0	1	0	0	0	2870	1377	48	3	369	3	CCDC91	12	28459762	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	21512816	28459762	105392133	65	4807											
SP7	121340	broad.mit.edu	37	chr12	53722081	53722081	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggggccactgggagggggaCccgggcctggttctccatgg	19	11	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr12:53722081C>G	uc001sct.2	-	2	1252	c.1145G>C	c.(1144-1146)GGT>GCT	p.G382A	SP7_uc001scu.2_Missense_Mutation_p.G364A|SP7_uc001scv.2_Missense_Mutation_p.G382A	NM_152860	NP_690599	Q8TDD2	SP7_HUMAN	osterix	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGAGGGGGACCCGGGCCTGG	0.672											OREG0021867	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	53722081	G	G	53722081	3	3	72	1	0	0	0	0	1	0	0	0	14969	507	18	5	154	5	SP7	12	53722081	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	25262319	53722081	80129814	66	4808											
KSR2	283455	broad.mit.edu	37	chr12	117977618	117977618	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagggagggggggtgctggCgaggagggcgtggaggacgt	27	4	0	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr12:117977618C>T	uc001two.2	-	10	1561	c.1506G>A	c.(1504-1506)TCG>TCA	p.S502S		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	531	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGGTGCTGGCGAGGAGGGCG	0.627													T	117977618	T	T	117977618	2	4	72	1	0	0	0	0	0	0	0	1	8582	755	27	1		1	KSR2	12	117977618	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	64255537	117977618	15874277	67	4809											
FLT1	2321	broad.mit.edu	37	chr13	28971149	28971149	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtcccaactttattggaagcTatgcaaatgtagattccaga	8	8	0	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr13:28971149T>C	uc001usb.3	-	12	1893	c.1608A>G	c.(1606-1608)ATA>ATG	p.I536M	FLT1_uc010aar.1_Missense_Mutation_p.I536M|FLT1_uc001usc.3_Missense_Mutation_p.I536M|FLT1_uc010aas.1_RNA|FLT1_uc010aat.1_Missense_Mutation_p.I19M	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	536	Ig-like C2-type 5.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TATTGGAAGCTATGCAAATGT	0.413													C	28971149	C	C	28971149	3	2	72	1	0	0	0	0	1	0	0	0	5941	1512	53	4	2669	4	FLT1	13	28971149	Missense_Mutation	SNP	T	TCGA-06-0939-01A-01D-1353-08		28971149	86198729	68	4810											
BRCA2	675	broad.mit.edu	37	chr13	32937431	32937431	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgacataatttcattgagcGcaaatatatctgaaacttct	5	8	3	3	rs80359052	by1000genomes	TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr13:32937431G>A	uc001uub.1	+	18	8319	c.8092G>A	c.(8092-8094)GCA>ACA	p.A2698T		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2698					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TTCATTGAGCGCAAATATATC	0.378			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			A	32937431	A	A	32937431	3	1	72	1	0	0	0	0	1	0	0	0	1499	1087	38	1	8158	1	BRCA2	13	32937431	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	3966282	32937431	82232447	69	4811											
RB1	5925	broad.mit.edu	37	chr13	48953730	48953730	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctttttgtttgtttgtagCgatacaaacttggagttcgc	9	6	1	0	rs3092891		TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr13:48953730C>T	uc001vcb.2	+	14	1499	c.1333C>T	c.(1333-1335)CGA>TGA	p.R445*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	445	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.R445*(2)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTTTGTAGCGATACAAACT	0.204		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	48953730	T	T	48953730	4	4	72	1	0	0	0	0	0	1	0	0	13098	782	27	1	1387	1	RB1	13	48953730	Nonsense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	16016299	48953730	66216148	70	4812											
IPO5	3843	broad.mit.edu	37	chr13	98641352	98641352	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccagtggcccgaaggtttgaAgttcctttttgattcagtca	10	9	2	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr13:98641352A>T	uc001vnf.1	+	4	466	c.401A>T	c.(400-402)AAG>ATG	p.K134M	IPO5_uc001vne.2_Missense_Mutation_p.K152M|IPO5_uc010tik.1_Intron|IPO5_uc010til.1_Missense_Mutation_p.K74M	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	134					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						GAAGGTTTGAAGTTCCTTTTT	0.383													T	98641352	T	T	98641352	3	4	72	1	0	0	0	0	1	0	0	0	7796	72	3	5	473	5	IPO5	13	98641352	Missense_Mutation	SNP	A	TCGA-06-0939-01A-01D-1353-08	49687622	98641352	16528526	71	4813											
SLC22A17	51310	broad.mit.edu	37	chr14	23820969	23820969	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacagccctcacctgtctgcGgggtaacccaggaacaggta	12	13	2	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr14:23820969G>A	uc001wjl.2	-	2	419	c.363C>T	c.(361-363)CCC>CCT	p.P121P	SLC22A17_uc010akk.2_5'UTR|SLC22A17_uc001wjn.2_Intron|SLC22A17_uc001wjm.2_Silent_p.P121P|SLC22A17_uc010akl.1_Silent_p.P121P	NM_020372	NP_065105	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17 isoform a	121					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity				0	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		ACCTGTCTGCGGGGTAACCCA	0.617													A	23820969	A	A	23820969	2	1	72	1	0	0	0	0	0	0	0	1	14448	1103	39	2		2	SLC22A17	14	23820969	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08		23820969	83528571	72	4814											
FSCB	84075	broad.mit.edu	37	chr14	44975096	44975096	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctggtggaggcagaatttcAgcaggaggctcttctgaagg	16	7	3	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr14:44975096A>G	uc001wvn.2	-	1	1404	c.1095T>C	c.(1093-1095)GCT>GCC	p.A365A		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	365	Pro-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		GCAGAATTTCAGCAGGAGGCT	0.493													G	44975096	G	G	44975096	2	3	72	1	0	0	0	0	0	0	0	1	6066	175	7	4		4	FSCB	14	44975096	Silent	SNP	A	TCGA-06-0939-01A-01D-1353-08	21154127	44975096	62374444	73	4815											
PCNX	22990	broad.mit.edu	37	chr14	71444226	71444226	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctactgcagtggaacggaccGggacactaacagtactgtca	11	11	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr14:71444226G>A	uc001xmo.2	+	6	1618	c.1172G>A	c.(1171-1173)CGG>CAG	p.R391Q	PCNX_uc001xmn.3_Missense_Mutation_p.R391Q|PCNX_uc010are.1_Missense_Mutation_p.R391Q	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	391						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GGAACGGACCGGGACACTAAC	0.498													A	71444226	A	A	71444226	3	1	72	1	0	0	0	0	1	0	0	0	11591	1116	39	2	1194	2	PCNX	14	71444226	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	26469130	71444226	35905314	74	4816											
ESRRB	2103	broad.mit.edu	37	chr14	76964704	76964704	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgccgctgctgcggcagaCggccgccaaggccgtgcagc	15	16	0	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr14:76964704C>T	uc001xsq.1	+	7	1272	c.1205C>T	c.(1204-1206)ACG>ATG	p.T402M	ESRRB_uc001xsr.2_Missense_Mutation_p.T402M|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	402						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CTGCGGCAGACGGCCGCCAAG	0.627													T	76964704	T	T	76964704	3	4	72	1	0	0	0	0	1	0	0	0	5261	536	19	1	1227	1	ESRRB	14	76964704	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	5520478	76964704	30384836	75	4817											
BCL11B	64919	broad.mit.edu	37	chr14	99640778	99640778	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaacaccttgccgcagtactCgcacgtgtcgctgcggcggc	13	15	0	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr14:99640778C>T	uc001yga.2	-	4	2662	c.2395G>A	c.(2395-2397)GAG>AAG	p.E799K	BCL11B_uc001ygb.2_Missense_Mutation_p.E728K	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	799	C2H2-type 4.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CCGCAGTACTCGCACGTGTCG	0.597			T	TLX3	T-ALL								T	99640778	T	T	99640778	3	4	72	1	0	0	0	0	1	0	0	0	1364	893	31	2	293	2	BCL11B	14	99640778	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	22676074	99640778	7708762	76	4818											
FAM82A2	55177	broad.mit.edu	37	chr15	41046948	41046948	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcaacagtcccagcccggCacgggcaccacccagggctc	11	19	0	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr15:41046948C>T	uc001zmo.1	-	2	178	c.34G>A	c.(34-36)GCC>ACC	p.A12T	FAM82A2_uc001zmp.1_Missense_Mutation_p.A12T|FAM82A2_uc001zmq.1_Missense_Mutation_p.A12T	NM_018145	NP_060615	Q96TC7	RMD3_HUMAN	family with sequence similarity 82, member A2	12					apoptosis|cell differentiation	integral to membrane|microtubule|mitochondrial membrane|nucleus|spindle pole	protein binding				0						CCCAGCCCGGCACGGGCACCA	0.572													T	41046948	T	T	41046948	3	4	72	1	0	0	0	0	1	0	0	0	5631	710	25	3	1426	3	FAM82A2	15	41046948	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08		41046948	61484444	77	4819											
SPINT1	6692	broad.mit.edu	37	chr15	41146113	41146113	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcagctctggggctcaggCgactttcccccagggtgagt	15	12	2	1	rs145193299		TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr15:41146113C>T	uc001zna.2	+	5	1151	c.947C>T	c.(946-948)GCG>GTG	p.A316V	SPINT1_uc001znb.2_Intron|SPINT1_uc001znc.2_Intron|SPINT1_uc010ucs.1_Missense_Mutation_p.A316V	NM_181642	NP_857593	O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	316						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GGGGCTCAGGCGACTTTCCCC	0.592													T	41146113	T	T	41146113	3	4	72	1	0	0	0	0	1	0	0	0	15067	768	27	1	961	1	SPINT1	15	41146113	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	99165	41146113	61385279	78	4820											
TP53BP1	7158	broad.mit.edu	37	chr15	43748820	43748820	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctcagaccctgaagacccCtcctctggatggtgttcttt	8	14	3	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr15:43748820C>T	uc001zrs.2	-	12	2119	c.1971G>A	c.(1969-1971)GAG>GAA	p.E657E	TP53BP1_uc010udp.1_Silent_p.E657E|TP53BP1_uc001zrq.3_Silent_p.E662E|TP53BP1_uc001zrr.3_Silent_p.E662E|TP53BP1_uc010udq.1_Silent_p.E662E	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	657					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CTGAAGACCCCTCCTCTGGAT	0.483								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					T	43748820	T	T	43748820	2	4	72	1	0	0	0	0	0	0	0	1	16380	680	24	3		3	TP53BP1	15	43748820	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	2602707	43748820	58782572	79	4821											
ADAMTS18	170692	broad.mit.edu	37	chr16	77401546	77401546	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgacccgcaggggagctgtaGttgtgttcctgggccagaag	16	9	0	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr16:77401546G>T	uc002ffc.3	-	4	989	c.570C>A	c.(568-570)AAC>AAA	p.N190K	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	190					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GGGAGCTGTAGTTGTGTTCCT	0.502													T	77401546	T	T	77401546	3	4	72	1	0	0	0	0	1	0	0	0	263	1020	36	5	3175	5	ADAMTS18	16	77401546	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08		77401546	12953207	80	4822											
OR1E2	8388	broad.mit.edu	37	chr17	3336801	3336801	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccatggccacaaggaggaagCtctctagatccgaaaaatac	9	11	1	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr17:3336801C>T	uc010vre.1	-	1	335	c.335G>A	c.(334-336)AGC>AAC	p.S112N		NM_003554	NP_003545	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			large_intestine(1)	1						AAGGAGGAAGCTCTCTAGATC	0.522													T	3336801	T	T	3336801	3	4	72	1	0	0	0	0	1	0	0	0	10955	797	28	3	639	3	OR1E2	17	3336801	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08		3336801	77858409	81	4823											
TRPV1	7442	broad.mit.edu	37	chr17	3486725	3486725	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttttccatcttaaagggaggCtgtgagatgcagagaagttg	13	5	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr17:3486725C>G	uc010vrr.1	-	8	1911	c.1384_splice	c.e8-1	p.P462_splice	TRPV1_uc010vro.1_Splice_Site_p.P473_splice|TRPV1_uc010vrp.1_Splice_Site_p.P402_splice|TRPV1_uc010vrq.1_Splice_Site_p.P460_splice|TRPV1_uc010vrs.1_Splice_Site_p.P462_splice|TRPV1_uc010vrt.1_Splice_Site_p.P462_splice|TRPV1_uc010vru.1_Splice_Site_p.P462_splice	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,						cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	TAAAGGGAGGCTGTGAGATGC	0.473													G	3486725	G	G	3486725	5	3	72	1	0	0	0	0	0	0	1	0	16592	811	28	5	841	5	TRPV1	17	3486725	Splice_Site	SNP	C	TCGA-06-0939-01A-01D-1353-08	149924	3486725	77708485	82	4824											
PLXDC1	57125	broad.mit.edu	37	chr17	37295949	37295949	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggcagcgtgtccatggccagGgtgcccccacccaggtcctg	14	16	0	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr17:37295949G>T	uc002hrg.2	-	2	425	c.213C>A	c.(211-213)ACC>ACA	p.T71T	PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	71	Extracellular (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						CCATGGCCAGGGTGCCCCCAC	0.672													T	37295949	T	T	37295949	2	4	72	1	0	0	0	0	0	0	0	1	12117	1219	43	5		5	PLXDC1	17	37295949	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	33809224	37295949	43899261	83	4825											
KRT13	3860	broad.mit.edu	37	chr17	39661434	39661434	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgttggcctcctccagggcGcgcaccttctccaggtagga	13	15	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr17:39661434G>A	uc002hwu.1	-	1	432	c.369C>T	c.(367-369)CGC>CGT	p.R123R	KRT13_uc002hwv.1_Silent_p.R123R|KRT13_uc002hww.2_Silent_p.R16R|KRT13_uc010wfr.1_Silent_p.R16R|KRT13_uc010cxo.2_Silent_p.R123R|KRT13_uc002hwx.1_Silent_p.R111R	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	123	Coil 1A.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				CCTCCAGGGCGCGCACCTTCT	0.532													A	39661434	A	A	39661434	2	1	72	1	0	0	0	0	0	0	0	1	8450	1074	38	1		1	KRT13	17	39661434	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	2365485	39661434	41533776	84	4826											
HLF	3131	broad.mit.edu	37	chr17	53398080	53398080	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catggcagccaagcgctcccGcgacgcccggaggctgaaag	14	15	0	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr17:53398080G>A	uc002iug.1	+	4	1253	c.728G>A	c.(727-729)CGC>CAC	p.R243H	HLF_uc010dce.1_Missense_Mutation_p.R158H|HLF_uc002iuh.2_Missense_Mutation_p.R158H|HLF_uc010wni.1_Missense_Mutation_p.R190H	NM_002126	NP_002117	Q16534	HLF_HUMAN	hepatic leukemia factor	243	Basic motif.				multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						AAGCGCTCCCGCGACGCCCGG	0.547			T	TCF3	ALL								A	53398080	A	A	53398080	3	1	72	1	0	0	0	0	1	0	0	0	7214	1087	38	1	742	1	HLF	17	53398080	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	13736646	53398080	27797130	85	4827											
TLK2	11011	broad.mit.edu	37	chr17	60679467	60679467	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attacagattttggtctttcGaagatcatggatgatgatag	10	4	2	4			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr17:60679467G>A	uc010ddp.2	+	20	2119	c.1851G>A	c.(1849-1851)TCG>TCA	p.S617S	TLK2_uc002izx.3_Silent_p.S443S|TLK2_uc002izz.3_Silent_p.S595S|TLK2_uc002jaa.3_Silent_p.S563S|TLK2_uc010wpd.1_Silent_p.S563S	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	617	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						TTGGTCTTTCGAAGATCATGG	0.383													A	60679467	A	A	60679467	2	1	72	1	0	0	0	0	0	0	0	1	15941	1045	37	2		2	TLK2	17	60679467	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	7281387	60679467	20515743	86	4828											
ABCA10	10349	broad.mit.edu	37	chr17	67181653	67181653	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttaacaggctggtaagaggcGtcttcgggatttgttccaga	13	7	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr17:67181653G>A	uc010dfa.1	-	21	3341	c.2462C>T	c.(2461-2463)ACG>ATG	p.T821M	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.T422M	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	821					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GGTAAGAGGCGTCTTCGGGAT	0.363													A	67181653	A	A	67181653	3	1	72	1	0	0	0	0	1	0	0	0	29	1145	40	1	2249	1	ABCA10	17	67181653	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	6502186	67181653	14013557	87	4829											
P4HB	5034	broad.mit.edu	37	chr17	79804920	79804920	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acagcaggatgtgagtcttgAtttcacctccaaaaatcttc	7	10	3	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr17:79804920A>C	uc002kbn.1	-	6	955	c.758T>G	c.(757-759)ATC>AGC	p.I253S	P4HB_uc002kbl.1_Intron|P4HB_uc002kbm.1_5'UTR	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	253					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			GTGAGTCTTGATTTCACCTCC	0.468													C	79804920	C	C	79804920	3	2	72	1	0	0	0	0	1	0	0	0	11359	333	12	5	792	5	P4HB	17	79804920	Missense_Mutation	SNP	A	TCGA-06-0939-01A-01D-1353-08	12623267	79804920	1390290	88	4830											
LAMA3	3909	broad.mit.edu	37	chr18	21492813	21492813	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagaaaatgggggtactgagAatatgtttgtgatgtacctt	13	3	0	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr18:21492813A>G	uc002kuq.2	+	56	7383	c.7297A>G	c.(7297-7299)AAT>GAT	p.N2433D	LAMA3_uc002kur.2_Missense_Mutation_p.N2377D|LAMA3_uc002kus.3_Missense_Mutation_p.N824D|LAMA3_uc002kut.3_Missense_Mutation_p.N768D	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2433	Laminin G-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGTACTGAGAATATGTTTGT	0.398													G	21492813	G	G	21492813	3	3	72	1	0	0	0	0	1	0	0	0	8607	246	9	4	7694	4	LAMA3	18	21492813	Missense_Mutation	SNP	A	TCGA-06-0939-01A-01D-1353-08		21492813	56584435	89	4831											
TMEM146	257062	broad.mit.edu	37	chr19	5748191	5748191	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcagctcgtcgacaccgtcCgggtgaaaaaaggagaccag	13	11	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr19:5748191C>T	uc002mda.2	+	10	890	c.829C>T	c.(829-831)CGG>TGG	p.R277W	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	277	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CGACACCGTCCGGGTGAAAAA	0.542													T	5748191	T	T	5748191	3	4	72	1	0	0	0	0	1	0	0	0	16057	643	23	2	867	2	TMEM146	19	5748191	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08		5748191	53380792	90	4832											
CATSPERG	57828	broad.mit.edu	37	chr19	38851477	38851477	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccactatgacttggagcGgaaagggtgagaagacaccg	14	9	0	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr19:38851477G>A	uc002oih.3	+	16	1961	c.1874G>A	c.(1873-1875)CGG>CAG	p.R625Q	CATSPERG_uc002oig.3_Missense_Mutation_p.R585Q|CATSPERG_uc002oif.3_Missense_Mutation_p.R265Q|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	625	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						GACTTGGAGCGGAAAGGGTGA	0.403													A	38851477	A	A	38851477	3	1	72	1	0	0	0	0	1	0	0	0	2692	1116	39	2	1932	2	CATSPERG	19	38851477	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	33103286	38851477	20277506	91	4833											
ZNF780A	284323	broad.mit.edu	37	chr19	40580618	40580618	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtttctcaccagtatgcaaTttctgatgtcgaataaggtg	10	7	2	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr19:40580618T>C	uc002omy.2	-	6	1956	c.1731A>G	c.(1729-1731)AAA>AAG	p.K577K	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Silent_p.K577K|ZNF780A_uc010xvh.1_Silent_p.K578K	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	577	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CAGTATGCAATTTCTGATGTC	0.388													C	40580618	C	C	40580618	2	2	72	1	0	0	0	0	0	0	0	1	18149	1490	52	4		4	ZNF780A	19	40580618	Silent	SNP	T	TCGA-06-0939-01A-01D-1353-08	1729141	40580618	18548365	92	4834											
PPFIA3	8541	broad.mit.edu	37	chr19	49633717	49633717	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggccctggagcggcagcgcgCcgaggtgtgccagctgcggg	20	13	0	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr19:49633717C>G	uc002pmr.2	+	7	1072	c.740C>G	c.(739-741)GCC>GGC	p.A247G	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010emt.2_Missense_Mutation_p.A171G|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Missense_Mutation_p.A115G	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	247	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CGGCAGCGCGCCGAGGTGTGC	0.692													G	49633717	G	G	49633717	3	3	72	1	0	0	0	0	1	0	0	0	12311	739	26	5	762	5	PPFIA3	19	49633717	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	9053099	49633717	9495266	93	4835											
ZNF544	27300	broad.mit.edu	37	chr19	58772416	58772416	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttcatggtactcacctcagaGagactgtttgctcaaaggga	10	9	4	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr19:58772416G>C	uc010euo.2	+	7	918	c.444G>C	c.(442-444)GAG>GAC	p.E148D	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.E120D|ZNF544_uc010yhy.1_Missense_Mutation_p.E120D|ZNF544_uc002qrt.3_Missense_Mutation_p.E6D|ZNF544_uc002qru.3_Missense_Mutation_p.E6D|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TCACCTCAGAGAGACTGTTTG	0.448													C	58772416	C	C	58772416	3	2	72	1	0	0	0	0	1	0	0	0	17974	933	33	5	458	5	ZNF544	19	58772416	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	9138699	58772416	356567	94	4836											
MYH7B	57644	broad.mit.edu	37	chr20	33586908	33586908	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaggagggcgtggaggctGccaacgccaagtgctcatcg	16	11	1	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr20:33586908G>A	uc002xbi.1	+	34	4458	c.4366G>A	c.(4366-4368)GCC>ACC	p.A1456T		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1414	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CGTGGAGGCTGCCAACGCCAA	0.607													A	33586908	A	A	33586908	3	1	72	1	0	0	0	0	1	0	0	0	10040	1319	46	3	4500	3	MYH7B	20	33586908	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08		33586908	29438612	95	4837											
SALL4	57167	broad.mit.edu	37	chr20	50407987	50407987	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gccacagtggagaaagggctCtggaagagcaccgagcccgg	16	11	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr20:50407987C>T	uc002xwh.3	-	2	1136	c.1035G>A	c.(1033-1035)CAG>CAA	p.Q345Q	SALL4_uc010gii.2_Silent_p.Q345Q|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	345					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AGAAAGGGCTCTGGAAGAGCA	0.632													T	50407987	T	T	50407987	2	4	72	1	0	0	0	0	0	0	0	1	13813	912	32	3		3	SALL4	20	50407987	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	16821079	50407987	12617533	96	4838											
COL20A1	57642	broad.mit.edu	37	chr20	61942767	61942767	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctctgcctccgccccgggCgctgaccctggccgcagtga	12	19	1	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr20:61942767C>T	uc011aau.1	+	12	1515	c.1415C>T	c.(1414-1416)GCG>GTG	p.A472V	COL20A1_uc011aav.1_Missense_Mutation_p.A293V	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	472	Fibronectin type-III 3.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					CCGCCCCGGGCGCTGACCCTG	0.687													T	61942767	T	T	61942767	3	4	72	1	0	0	0	0	1	0	0	0	3679	768	27	1	1457	1	COL20A1	20	61942767	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	11534780	61942767	1082753	97	4839											
CCT8L2	150160	broad.mit.edu	37	chr22	17072541	17072541	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagtgtgagggtctcctcGtcgacctcccccaacaccac	9	18	1	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr22:17072541G>A	uc002zlp.1	-	1	1160	c.900C>T	c.(898-900)GAC>GAT	p.D300D		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	300					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GGGTCTCCTCGTCGACCTCCC	0.493													A	17072541	A	A	17072541	2	1	72	1	0	0	0	0	0	0	0	1	2961	1136	40	1		1	CCT8L2	22	17072541	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08		17072541	34232025	98	4840											
PARVG	64098	broad.mit.edu	37	chr22	44586519	44586519	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacctctccctcccaaccaaCgtccaggtggaggtcatcac	8	17	3	0	rs3842780	byFrequency	TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chr22:44586519C>T	uc011aqe.1	+	7	901	c.477C>T	c.(475-477)AAC>AAT	p.N159N	PARVG_uc003bep.2_Silent_p.N159N|PARVG_uc011aqf.1_Silent_p.N159N|PARVG_uc003beq.2_RNA|PARVG_uc003ber.2_RNA	NM_001137605	NP_001131077	Q9HBI0	PARVG_HUMAN	parvin, gamma	159					cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding				0		Ovarian(80;0.024)|all_neural(38;0.0299)				TCCCAACCAACGTCCAGGTGG	0.602													T	44586519	T	T	44586519	2	4	72	1	0	0	0	0	0	0	0	1	11470	535	19	1		1	PARVG	22	44586519	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	27513978	44586519	6718047	99	4841											
FIGF	2277	broad.mit.edu	37	chrX	15364311	15364311	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttttctcctttggaaagcGgcaatgctttgcacatgctg	9	11	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:15364311G>A	uc004cwt.1	-	7	1518	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C		NM_004469	NP_004460	O43915	VEGFD_HUMAN	vascular endothelial growth factor D	337					angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					TTTGGAAAGCGGCAATGCTTT	0.478													A	15364311	A	A	15364311	3	1	72	1	0	0	0	0	1	0	0	0	5889	1116	39	2	59	2	FIGF	23	15364311	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08		15364311	139906249	100	4842											
PTCHD1	139411	broad.mit.edu	37	chrX	23397772	23397772	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taattacacgtttgcccataTatgtatcctgaataatgata	5	7	0	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:23397772T>C	uc004dal.3	+	2	424	c.416T>C	c.(415-417)ATA>ACA	p.I139T	PTCHD1_uc010nfu.1_Missense_Mutation_p.I139T	NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	139					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						TTTGCCCATATATGTATCCTG	0.433													C	23397772	C	C	23397772	3	2	72	1	0	0	0	0	1	0	0	0	12732	1406	49	4	422	4	PTCHD1	23	23397772	Missense_Mutation	SNP	T	TCGA-06-0939-01A-01D-1353-08	8033461	23397772	131872788	101	4843											
CYBB	1536	broad.mit.edu	37	chrX	37665738	37665738	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgcaggaaaggaacaatgcCggcttcctcagctacaacat	9	11	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:37665738C>T	uc004ddr.2	+	11	1474	c.1413C>T	c.(1411-1413)GCC>GCT	p.A471A	CYBB_uc011mkf.1_Silent_p.A439A|CYBB_uc011mkg.1_Silent_p.A204A	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	471	Cytoplasmic (Potential).				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GGAACAATGCCGGCTTCCTCA	0.527													T	37665738	T	T	37665738	2	4	72	1	0	0	0	0	0	0	0	1	4133	639	23	2		2	CYBB	23	37665738	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	14267966	37665738	117604822	102	4844											
PAGE1	8712	broad.mit.edu	37	chrX	49455937	49455937	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaagctcacacccagtcttTggctgaaccagttcctggct	8	15	2	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:49455937T>C	uc004dom.2	-	4	340	c.207A>G	c.(205-207)CCA>CCG	p.P69P		NM_003785	NP_003776	O75459	GAGB1_HUMAN	P antigen family, member 1	69					cellular defense response					skin(1)	1	Ovarian(276;0.236)					ACCCAGTCTTTGGCTGAACCA	0.438													C	49455937	C	C	49455937	2	2	72	1	0	0	0	0	0	0	0	1	11389	1799	63	4		4	PAGE1	23	49455937	Silent	SNP	T	TCGA-06-0939-01A-01D-1353-08	11790199	49455937	105814623	103	4845											
FOXR2	139628	broad.mit.edu	37	chrX	55650496	55650496	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcagcccccacaaaaagacGaagggtctaactgctcagag	9	13	3	2			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:55650496G>A	uc004duo.2	+	1	664	c.352G>A	c.(352-354)GAA>AAA	p.E118K		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	118					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						ACAAAAAGACGAAGGGTCTAA	0.527													A	55650496	A	A	55650496	3	1	72	1	0	0	0	0	1	0	0	0	6032	1059	37	2	354	2	FOXR2	23	55650496	Missense_Mutation	SNP	G	TCGA-06-0939-01A-01D-1353-08	6194559	55650496	99620064	104	4846											
SLC7A3	84889	broad.mit.edu	37	chrX	70148360	70148360	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgtagtcctcttctgtgagcTtccagttgtgcacgtccccc	9	15	2	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:70148360T>C	uc004dyn.2	-	4	811	c.653A>G	c.(652-654)AAG>AGG	p.K218R	SLC7A3_uc004dyo.2_Missense_Mutation_p.K218R	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	218	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TTCTGTGAGCTTCCAGTTGTG	0.507													C	70148360	C	C	70148360	3	2	72	1	0	0	0	0	1	0	0	0	14698	1609	56	4	1242	4	SLC7A3	23	70148360	Missense_Mutation	SNP	T	TCGA-06-0939-01A-01D-1353-08	14497864	70148360	85122200	105	4847											
ZCCHC5	203430	broad.mit.edu	37	chrX	77912605	77912605	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataagcggcctttgtgccaaCggacccattcagcttcactg	9	13	2	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:77912605C>T	uc004edc.1	-	2	1609	c.1313G>A	c.(1312-1314)CGT>CAT	p.R438H		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	438							nucleic acid binding|zinc ion binding			ovary(1)	1						TTTGTGCCAACGGACCCATTC	0.547													T	77912605	T	T	77912605	3	4	72	1	0	0	0	0	1	0	0	0	17588	536	19	1	118	1	ZCCHC5	23	77912605	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	7764245	77912605	77357955	106	4848											
RNF113A	7737	broad.mit.edu	37	chrX	119005259	119005259	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcctctggtcccacgggtttCgccgaacgggtggatttata	12	11	1	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:119005259C>T	uc004esb.2	-	1	533	c.318G>A	c.(316-318)GCG>GCA	p.A106A	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	106							nucleic acid binding|zinc ion binding			breast(2)	2						CCACGGGTTTCGCCGAACGGG	0.552													T	119005259	T	T	119005259	2	4	72	1	0	0	0	0	0	0	0	1	13427	871	31	2		2	RNF113A	23	119005259	Silent	SNP	C	TCGA-06-0939-01A-01D-1353-08	41092654	119005259	36265301	107	4849											
ENOX2	10495	broad.mit.edu	37	chrX	129759313	129759313	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcagcttcaagccctcgaagCcacagaatttccatctcttt	5	14	3	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:129759313C>A	uc004evw.2	-	16	2226	c.1808G>T	c.(1807-1809)GGC>GTC	p.G603V	ENOX2_uc004evx.2_Missense_Mutation_p.G574V|ENOX2_uc004evy.2_Missense_Mutation_p.G574V|ENOX2_uc004evv.2_Missense_Mutation_p.G428V	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	603					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						GCCCTCGAAGCCACAGAATTT	0.438													A	129759313	A	A	129759313	3	1	72	1	0	0	0	0	1	0	0	0	5127	739	26	5	28	5	ENOX2	23	129759313	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	10754054	129759313	25511247	108	4850											
SLITRK2	84631	broad.mit.edu	37	chrX	144904765	144904765	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagtgattccagtcagagGggcagccatgctgacaccca	12	13	1	3			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:144904765G>A	uc004fcd.2	+	5	1812	c.822G>A	c.(820-822)AGG>AGA	p.R274R	SLITRK2_uc010nsp.2_Silent_p.R274R|SLITRK2_uc010nso.2_Silent_p.R274R|SLITRK2_uc011mwq.1_Silent_p.R274R|SLITRK2_uc011mwr.1_Silent_p.R274R|SLITRK2_uc011mws.1_Silent_p.R274R|SLITRK2_uc004fcg.2_Silent_p.R274R|SLITRK2_uc011mwt.1_Silent_p.R274R	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	274	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGTCAGAGGGGCAGCCATG	0.557													A	144904765	A	A	144904765	2	1	72	1	0	0	0	0	0	0	0	1	14743	1223	43	3		3	SLITRK2	23	144904765	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	15145452	144904765	10365795	109	4851											
MTM1	4534	broad.mit.edu	37	chrX	149832009	149832009	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatcaatcgagttttatatcCagttgccagtatgcgtcact	7	9	2	0			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:149832009C>T	uc004fef.3	+	14	1647	c.1571C>T	c.(1570-1572)CCA>CTA	p.P524L	MTM1_uc011mxx.1_RNA|MTM1_uc011mxy.1_Missense_Mutation_p.P487L|MTM1_uc011mxz.1_Missense_Mutation_p.P409L|MTM1_uc010nte.2_Missense_Mutation_p.P392L	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	524	Myotubularin phosphatase.				endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GTTTTATATCCAGTTGCCAGT	0.358													T	149832009	T	T	149832009	3	4	72	1	0	0	0	0	1	0	0	0	9937	594	21	3	1621	3	MTM1	23	149832009	Missense_Mutation	SNP	C	TCGA-06-0939-01A-01D-1353-08	4927244	149832009	5438551	110	4852											
HCFC1	3054	broad.mit.edu	37	chrX	153229664	153229664	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	acaagggagaagctgtgcccGagtcgaggacacggaggggg	19	8	0	1			TCGA-06-0939-01A-01D-1353-08	TCGA-06-0939-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca1a0aa7-2b4e-4479-966f-9de854b9dddc	6a8ffcc4-f3eb-4430-a734-8a2a46fbfd95	g.chrX:153229664G>T	uc004fjp.2	-	3	942	c.414C>A	c.(412-414)CTC>CTA	p.L138L		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	138	Kelch 2.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCTGTGCCCGAGTCGAGGAC	0.562													T	153229664	T	T	153229664	2	4	72	1	0	0	0	0	0	0	0	1	6991	1045	37	5		5	HCFC1	23	153229664	Silent	SNP	G	TCGA-06-0939-01A-01D-1353-08	3397655	153229664	2040896	111	4853											
ATP13A2	23400	broad.mit.edu	37	chr1	17316634	17316634	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agcctcaccttaacgccattCacggctgtgggggactccat	10	14	2	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:17316634C>T	uc001baa.2	-	21	2590	c.2400G>A	c.(2398-2400)GTG>GTA	p.V800V	ATP13A2_uc001azz.1_5'Flank|ATP13A2_uc001bab.2_Silent_p.V795V|ATP13A2_uc001bac.2_Silent_p.V795V	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	800	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		TAACGCCATTCACGGCTGTGG	0.642													T	17316634	T	T	17316634	2	4	73	1	0	0	0	0	0	0	0	1	1124	813	29	3		3	ATP13A2	1	17316634	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08		17316634	231933987	1	4854											
TAS1R2	80834	broad.mit.edu	37	chr1	19166669	19166669	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atctggaaagaacgcacggcGatacaggagatgcagattgt	13	7	1	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:19166669G>A	uc001bba.1	-	6	1945	c.1944C>T	c.(1942-1944)ATC>ATT	p.I648I		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	648	Helical; Name=3; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	AACGCACGGCGATACAGGAGA	0.627													A	19166669	A	A	19166669	2	1	73	1	0	0	0	0	0	0	0	1	15560	1048	37	2		2	TAS1R2	1	19166669	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08	1850035	19166669	230083952	2	4855											
KIF17	57576	broad.mit.edu	37	chr1	21009290	21009290	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcttcctgcgctcgtctgcGtagcgcttgcgccgcttgtg	13	14	1	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:21009290G>A	uc001bdr.3	-	11	2437	c.2319C>T	c.(2317-2319)TAC>TAT	p.Y773Y	KIF17_uc001bdp.3_Silent_p.Y51Y|KIF17_uc001bdq.3_Silent_p.Y51Y|KIF17_uc009vpx.2_Silent_p.Y143Y|KIF17_uc001bds.3_Silent_p.Y773Y	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	773	Potential.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GCTCGTCTGCGTAGCGCTTGC	0.622													A	21009290	A	A	21009290	2	1	73	1	0	0	0	0	0	0	0	1	8279	1140	40	1		1	KIF17	1	21009290	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08	1842621	21009290	228241331	3	4856											
GJB4	127534	broad.mit.edu	37	chr1	35227336	35227336	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggattatgacatgccccgcGtggtggcctgctccgtggag	15	11	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:35227336G>A	uc001bxv.1	+	2	851	c.481G>A	c.(481-483)GTG>ATG	p.V161M	GJB4_uc001bxw.3_Missense_Mutation_p.V161M	NM_153212	NP_694944	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4	161	Extracellular (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CATGCCCCGCGTGGTGGCCTG	0.582													A	35227336	A	A	35227336	3	1	73	1	0	0	0	0	1	0	0	0	6410	1145	40	1	483	1	GJB4	1	35227336	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	14218046	35227336	214023285	4	4857											
CD53	963	broad.mit.edu	37	chr1	111439300	111439300	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgttgtggtataaatggcaCgagtgattggaccagtggcc	15	6	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:111439300C>T	uc001dzw.2	+	7	620	c.449C>T	c.(448-450)ACG>ATG	p.T150M	CD53_uc001dzx.2_Missense_Mutation_p.T150M|CD53_uc010owa.1_Intron|CD53_uc001dzy.2_Intron	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	150	Extracellular (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		ATAAATGGCACGAGTGATTGG	0.428													T	111439300	T	T	111439300	3	4	73	1	0	0	0	0	1	0	0	0	3023	536	19	1	467	1	CD53	1	111439300	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	76211964	111439300	137811321	5	4858											
SPAG17	200162	broad.mit.edu	37	chr1	118558655	118558655	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agtctgctattctttctaatCctttggtgccgatccgattt	7	10	3	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:118558655C>A	uc001ehk.2	-	29	4288	c.4220G>T	c.(4219-4221)GGA>GTA	p.G1407V		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1407						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TCTTTCTAATCCTTTGGTGCC	0.448													A	118558655	A	A	118558655	3	1	73	1	0	0	0	0	1	0	0	0	14979	855	30	5	2531	5	SPAG17	1	118558655	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	7119355	118558655	130691966	6	4859											
FLG	2312	broad.mit.edu	37	chr1	152275641	152275641	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtacatgactggctgtatcGcggtgagaggatccggggtg	17	7	0	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:152275641G>A	uc001ezu.1	-	3	11757	c.11721C>T	c.(11719-11721)CGC>CGT	p.R3907R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3907	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCTGTATCGCGGTGAGAGG	0.502									Ichthyosis				A	152275641	A	A	152275641	2	1	73	1	0	0	0	0	0	0	0	1	5922	1074	38	1		1	FLG	1	152275641	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08	33716986	152275641	96974980	7	4860											
MUC1	4582	broad.mit.edu	37	chr1	155161953	155161953	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccggggctgtggctggagagTacgctgctggtcatactcac	15	11	2	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:155161953T>C	uc010pft.1	-	2	246	c.180A>G	c.(178-180)GTA>GTG	p.V60V	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_5'Flank|MUC1_uc001fhz.2_5'Flank|MUC1_uc010pfb.1_Intron|MUC1_uc010pfc.1_Intron|MUC1_uc009wph.2_Intron|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_Intron|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Intron|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Intron|MUC1_uc010pfi.1_Intron|MUC1_uc010pfj.1_Intron|MUC1_uc010pfk.1_Intron|MUC1_uc010pfl.1_Intron|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Intron|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Intron|MUC1_uc009wpo.2_Intron|MUC1_uc009wps.2_Intron|MUC1_uc009wpt.2_Intron|MUC1_uc001fic.2_Intron|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Intron|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Intron|MUC1_uc001fid.2_Intron|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Intron|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Intron|MUC1_uc001fiq.2_Intron|MUC1_uc009wpz.2_Intron|MUC1_uc010pfn.1_Intron|MUC1_uc009wqa.2_Intron|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Intron|MUC1_uc009wqc.2_Intron|MUC1_uc009wqd.2_Intron|MUC1_uc009wqb.2_Intron|MUC1_uc010pfq.1_Intron|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Intron|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Intron|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_Intron|MUC1_uc001fik.2_Intron|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Intron|MUC1_uc001fis.1_Intron|uc009wqh.2_5'Flank|MUC1_uc001fiv.1_Silent_p.V69V|MUC1_uc001fiw.1_Silent_p.V60V			P15941	MUC1_HUMAN	SubName: Full=MUC1 isoform M13;	60	Extracellular (Potential).					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGCTGGAGAGTACGCTGCTGG	0.587			T	IGH@	B-NHL								C	155161953	C	C	155161953	2	2	73	1	0	0	0	0	0	0	0	1	9970	1653	57	4		4	MUC1	1	155161953	Silent	SNP	T	TCGA-06-1804-01A-01D-1696-08	2886312	155161953	94088668	8	4861											
RIT1	6016	broad.mit.edu	37	chr1	155870206	155870206	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	actgaatctttcttcttccgGaatggtgattttagcctctt	7	9	4	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:155870206G>C	uc001fmh.1	-	6	820	c.633C>G	c.(631-633)TTC>TTG	p.F211L	RIT1_uc010pgr.1_Missense_Mutation_p.F175L	NM_006912	NP_008843	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	211					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			breast(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			TCTTCTTCCGGAATGGTGATT	0.423													C	155870206	C	C	155870206	3	2	73	1	0	0	0	0	1	0	0	0	13386	1165	41	5	30	5	RIT1	1	155870206	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	708253	155870206	93380415	9	4862											
IQGAP3	128239	broad.mit.edu	37	chr1	156503843	156503843	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccacggtgatgtacaccatGggtttggccacagccaccat	10	14	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:156503843G>A	uc001fpf.2	-	30	3906	c.3831C>T	c.(3829-3831)CCC>CCT	p.P1277P		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1277					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGTACACCATGGGTTTGGCCA	0.592													A	156503843	A	A	156503843	2	1	73	1	0	0	0	0	0	0	0	1	7816	1335	47	3		3	IQGAP3	1	156503843	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08	633637	156503843	92746778	10	4863											
SLAMF1	6504	broad.mit.edu	37	chr1	160607074	160607074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcctccttcctgctttcccGtatccccagggtgagattct	7	15	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr1:160607074G>A	uc001fwl.3	-	2	668	c.322C>T	c.(322-324)CGG>TGG	p.R108W	SLAMF1_uc010pjk.1_RNA|SLAMF1_uc010pjl.1_RNA|SLAMF1_uc010pjm.1_RNA|SLAMF1_uc001fwm.2_Missense_Mutation_p.R108W	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	108	Extracellular (Potential).				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CTGCTTTCCCGTATCCCCAGG	0.468													A	160607074	A	A	160607074	3	1	73	1	0	0	0	0	1	0	0	0	14367	1144	40	1	709	1	SLAMF1	1	160607074	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	4103231	160607074	88643547	11	4864											
PIKFYVE	200576	broad.mit.edu	37	chr2	209179975	209179975	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agttgctccatagtgactcaCtgtcatcatcttggagggac	10	10	4	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr2:209179975C>G	uc002vcz.2	+	15	2043	c.1885C>G	c.(1885-1887)CTG>GTG	p.L629V	PIKFYVE_uc010fun.1_Missense_Mutation_p.L310V|PIKFYVE_uc002vcy.1_Missense_Mutation_p.L573V	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	629					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TAGTGACTCACTGTCATCATC	0.423													G	209179975	G	G	209179975	3	3	73	1	0	0	0	0	1	0	0	0	11924	564	20	5	1950	5	PIKFYVE	2	209179975	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08		209179975	34019398	12	4865											
TNS1	7145	broad.mit.edu	37	chr2	218749762	218749762	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cactcaaggagcgcacctttGaaagcatcatcaaggtcctc	8	13	3	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr2:218749762G>T	uc002vgt.2	-	14	1265	c.867C>A	c.(865-867)TTC>TTA	p.F289L	TNS1_uc002vgr.2_Missense_Mutation_p.F289L|TNS1_uc002vgs.2_Missense_Mutation_p.F289L|TNS1_uc010zjv.1_Missense_Mutation_p.F289L|TNS1_uc010fvj.1_Missense_Mutation_p.F357L|TNS1_uc010fvk.1_Missense_Mutation_p.F414L|TNS1_uc002vgu.3_Missense_Mutation_p.F320L|TNS1_uc010fvi.1_5'UTR	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	289	C2 tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GCGCACCTTTGAAAGCATCAT	0.572													T	218749762	T	T	218749762	3	4	73	1	0	0	0	0	1	0	0	0	16340	1281	45	5	4420	5	TNS1	2	218749762	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	9569787	218749762	24449611	13	4866											
ITM2C	81618	broad.mit.edu	37	chr2	231740464	231740464	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaactacgagcgcatcaacGtgcctgtgccccagtttggc	11	13	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr2:231740464G>A	uc002vqz.2	+	3	511	c.391G>A	c.(391-393)GTG>ATG	p.V131M	ITM2C_uc002vra.2_Missense_Mutation_p.V84M|ITM2C_uc002vrb.2_Missense_Mutation_p.V131M|ITM2C_uc002vrc.2_Missense_Mutation_p.V20M|ITM2C_uc002vrd.2_Missense_Mutation_p.V20M	NM_030926	NP_112188	Q9NQX7	ITM2C_HUMAN	integral membrane protein 2C isoform 1	131					negative regulation of neuron projection development|neuron differentiation	Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	beta-amyloid binding				0		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;8.47e-12)|all cancers(144;3.44e-09)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		GCGCATCAACGTGCCTGTGCC	0.617													A	231740464	A	A	231740464	3	1	73	1	0	0	0	0	1	0	0	0	7914	1145	40	1	401	1	ITM2C	2	231740464	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	12990702	231740464	11458909	14	4867											
COL6A3	1293	broad.mit.edu	37	chr2	238275697	238275697	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttggcgtgtcttccccctttGtagaccactttgttgatggc	10	11	1	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr2:238275697G>C	uc002vwl.2	-	11	5418	c.5133C>G	c.(5131-5133)TAC>TAG	p.Y1711*	COL6A3_uc002vwo.2_Nonsense_Mutation_p.Y1505*|COL6A3_uc010znj.1_Nonsense_Mutation_p.Y1104*	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1711	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTCCCCCTTTGTAGACCACTT	0.557													C	238275697	C	C	238275697	4	2	73	1	0	0	0	0	0	1	0	0	3701	1372	48	5	4536	5	COL6A3	2	238275697	Nonsense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	6535233	238275697	4923676	15	4868											
ATP2B2	491	broad.mit.edu	37	chr3	10387071	10387071	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctcctgcggacccacctgCgtgatgcaggcgcctgtgaa	13	14	1	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr3:10387071C>T	uc003bvt.2	-	18	3139	c.2700G>A	c.(2698-2700)ACG>ACA	p.T900T	ATP2B2_uc003bvv.2_Silent_p.T855T|ATP2B2_uc003bvw.2_Silent_p.T855T|ATP2B2_uc010hdo.2_Silent_p.T605T	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	900	Extracellular (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GACCCACCTGCGTGATGCAGG	0.627													T	10387071	T	T	10387071	2	4	73	1	0	0	0	0	0	0	0	1	1140	755	27	1		1	ATP2B2	3	10387071	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08		10387071	187635359	16	4869											
CCDC52	152185	broad.mit.edu	37	chr3	113169336	113169336	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccgttcctccatactacctgGtgttagagactgtgctactg	9	12	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr3:113169336G>T	uc003eag.3	-	15	2461	c.2170C>A	c.(2170-2172)CCA>ACA	p.P724T	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Missense_Mutation_p.P620T	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	724					cell division|mitosis	centriole|spindle	protein binding				0						ATACTACCTGGTGTTAGAGAC	0.373													T	113169336	T	T	113169336	3	4	73	1	0	0	0	0	1	0	0	0	2822	1261	44	5	413	5	CCDC52	3	113169336	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	102782265	113169336	84853094	17	4870											
KIAA1257	57501	broad.mit.edu	37	chr3	128696988	128696988	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttggtattctcaatgccctgTtcagataattttctctgatt	6	8	3	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr3:128696988T>C	uc003elj.3	-	5	904	c.708A>G	c.(706-708)GAA>GAG	p.E236E	KIAA1257_uc003elg.1_Silent_p.E236E|KIAA1257_uc003eli.3_Silent_p.E124E	NM_020741	NP_065792	Q9ULG3	K1257_HUMAN	hypothetical protein LOC57501	236											0						CAATGCCCTGTTCAGATAATT	0.358													C	128696988	C	C	128696988	2	2	73	1	0	0	0	0	0	0	0	1	8218	1722	60	4		4	KIAA1257	3	128696988	Silent	SNP	T	TCGA-06-1804-01A-01D-1696-08	15527652	128696988	69325442	18	4871											
CLDN18	51208	broad.mit.edu	37	chr3	137717743	137717743	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcctgtcagggcttggggttCgtggtttcactgattgggat	16	7	2	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr3:137717743C>T	uc003ero.1	+	1	86	c.33C>T	c.(31-33)TTC>TTT	p.F11F		NM_001002026	NP_001002026	P56856	CLD18_HUMAN	claudin 18 isoform 2	11	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCTTGGGGTTCGTGGTTTCAC	0.557													T	137717743	T	T	137717743	2	4	73	1	0	0	0	0	0	0	0	1	3479	883	31	2		2	CLDN18	3	137717743	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	9020755	137717743	60304687	19	4872											
PLCH1	23007	broad.mit.edu	37	chr3	155203313	155203313	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtggcctcggacacagaatCctttatctccaccatttctt	6	13	2	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr3:155203313C>T	uc011bok.1	-	22	3107	c.2830G>A	c.(2830-2832)GAT>AAT	p.D944N	PLCH1_uc011boj.1_Missense_Mutation_p.D944N|PLCH1_uc011bol.1_Missense_Mutation_p.D906N	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	944					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GACACAGAATCCTTTATCTCC	0.522													T	155203313	T	T	155203313	3	4	73	1	0	0	0	0	1	0	0	0	12037	855	30	3	2274	3	PLCH1	3	155203313	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	17485570	155203313	42819117	20	4873											
PEX5L	51555	broad.mit.edu	37	chr3	179526143	179526143	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggaacagaacccctagacCtgtctgcaggtctgggtcga	13	11	2	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr3:179526143C>T	uc003fki.1	-	13	1565	c.1435G>A	c.(1435-1437)GGT>AGT	p.G479S	PEX5L_uc011bqd.1_Missense_Mutation_p.G436S|PEX5L_uc011bqe.1_Missense_Mutation_p.G287S|PEX5L_uc011bqf.1_Missense_Mutation_p.G371S|PEX5L_uc003fkj.1_Missense_Mutation_p.G444S|PEX5L_uc010hxd.1_Missense_Mutation_p.G477S|PEX5L_uc011bqg.1_Missense_Mutation_p.G455S|PEX5L_uc011bqh.1_Missense_Mutation_p.G420S	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	479	TPR 3.				protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			ACCCCTAGACCTGTCTGCAGG	0.458													T	179526143	T	T	179526143	3	4	73	1	0	0	0	0	1	0	0	0	11749	681	24	3	457	3	PEX5L	3	179526143	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	24322830	179526143	18496287	21	4874											
HTR3E	285242	broad.mit.edu	37	chr3	183823993	183823993	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatcacccacctgctgcacGtggccaccacccagccccca	6	22	2	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr3:183823993G>A	uc010hxq.2	+	8	1469	c.1003G>A	c.(1003-1005)GTG>ATG	p.V335M	HTR3E_uc003fml.3_Missense_Mutation_p.V320M|HTR3E_uc003fmm.2_Missense_Mutation_p.V350M|HTR3E_uc010hxr.2_Missense_Mutation_p.V361M|HTR3E_uc003fmn.2_Missense_Mutation_p.V335M	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	335	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CCTGCTGCACGTGGCCACCAC	0.667													A	183823993	A	A	183823993	3	1	73	1	0	0	0	0	1	0	0	0	7448	1145	40	1	1074	1	HTR3E	3	183823993	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	4297850	183823993	14198437	22	4875											
UNC5C	8633	broad.mit.edu	37	chr4	96199412	96199412	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agaattgttgttattcacctCagccactgggatcccttcag	8	11	3	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr4:96199412C>T	uc003htp.1	-	4	746	c.592G>A	c.(592-594)GAG>AAG	p.E198K	UNC5C_uc010ilc.1_Missense_Mutation_p.E198K|UNC5C_uc003htq.2_Missense_Mutation_p.E198K	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	198	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTATTCACCTCAGCCACTGGG	0.453													T	96199412	T	T	96199412	3	4	73	1	0	0	0	0	1	0	0	0	16990	835	29	3	2255	3	UNC5C	4	96199412	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08		96199412	94954864	23	4876											
ANK2	287	broad.mit.edu	37	chr4	114277204	114277204	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagcagccctgttgaaccaaAgatgaaggctggaatttttc	10	8	0	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr4:114277204A>T	uc003ibe.3	+	38	7530	c.7430A>T	c.(7429-7431)AAG>ATG	p.K2477M	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron|ANK2_uc011cgb.1_Missense_Mutation_p.K2492M	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2444					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GTTGAACCAAAGATGAAGGCT	0.502													T	114277204	T	T	114277204	3	4	73	1	0	0	0	0	1	0	0	0	621	72	3	5	7645	5	ANK2	4	114277204	Missense_Mutation	SNP	A	TCGA-06-1804-01A-01D-1696-08	18077792	114277204	76877072	24	4877											
IL2	3558	broad.mit.edu	37	chr4	123374886	123374886	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttagttccagaactattacGttgatattgctgattaagtc	7	6	0	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr4:123374886G>A	uc003ier.2	-	3	385	c.330C>T	c.(328-330)AAC>AAT	p.N110N		NM_000586	NP_000577	P60568	IL2_HUMAN	interleukin 2 precursor	110					anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			skin(1)	1				LUSC - Lung squamous cell carcinoma(721;0.185)		GAACTATTACGTTGATATTGC	0.353			T	TNFRSF17	intestinal T-cell lymphoma								A	123374886	A	A	123374886	2	1	73	1	0	0	0	0	0	0	0	1	7666	1136	40	1		1	IL2	4	123374886	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08	9097682	123374886	67779390	25	4878											
RBM46	166863	broad.mit.edu	37	chr4	155719190	155719190	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcttaataattatgaaattCgaccagggaagtttattggt	8	4	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr4:155719190C>T	uc003ioo.2	+	3	552	c.379C>T	c.(379-381)CGA>TGA	p.R127*	RBM46_uc011cim.1_Nonsense_Mutation_p.R127*|RBM46_uc003iop.1_Nonsense_Mutation_p.R127*	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	127	RRM 1.						nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)				TTATGAAATTCGACCAGGGAA	0.338													T	155719190	T	T	155719190	4	4	73	1	0	0	0	0	0	1	0	0	13140	876	31	2	385	2	RBM46	4	155719190	Nonsense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	32344304	155719190	35435086	26	4879											
GUCY1A3	2982	broad.mit.edu	37	chr4	156632019	156632019	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaacggaagtggaagtgtcGttaatgcctccctgcttcca	11	10	0	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr4:156632019G>A	uc003iov.2	+	7	1238	c.702G>A	c.(700-702)TCG>TCA	p.S234S	GUCY1A3_uc003iou.2_Silent_p.S234S|GUCY1A3_uc010iqc.2_Silent_p.S234S|GUCY1A3_uc003iow.2_Silent_p.S234S|GUCY1A3_uc010iqd.2_Silent_p.S233S|GUCY1A3_uc003iox.2_Silent_p.S234S|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Silent_p.S234S|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Silent_p.S234S	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	234					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TGGAAGTGTCGTTAATGCCTC	0.468													A	156632019	A	A	156632019	2	1	73	1	0	0	0	0	0	0	0	1	6894	1132	40	1		1	GUCY1A3	4	156632019	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08	912829	156632019	34522257	27	4880											
KIAA0947	23379	broad.mit.edu	37	chr5	5464633	5464633	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcacgcacttcctgtgcctgGccgactcccaccctgtgcat	9	18	0	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr5:5464633G>T	uc003jdm.3	+	13	5408	c.5186G>T	c.(5185-5187)GGC>GTC	p.G1729V		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1729	Pro-rich.									ovary(1)|central_nervous_system(1)	2						CCTGTGCCTGGCCGACTCCCA	0.587													T	5464633	T	T	5464633	3	4	73	1	0	0	0	0	1	0	0	0	8202	1203	42	5	5236	5	KIAA0947	5	5464633	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08		5464633	175450627	28	4881											
CDH9	1007	broad.mit.edu	37	chr5	26885950	26885950	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcgactgtagccatctttcCgagtcatgattcctgctgta	9	11	2	1	rs150128137		TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr5:26885950C>T	uc003jgs.1	-	11	1824	c.1655G>A	c.(1654-1656)CGG>CAG	p.R552Q	CDH9_uc011cnv.1_Missense_Mutation_p.R145Q	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	552	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GCCATCTTTCCGAGTCATGAT	0.343													T	26885950	T	T	26885950	3	4	73	1	0	0	0	0	1	0	0	0	3117	652	23	2	722	2	CDH9	5	26885950	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	21421317	26885950	154029310	29	4882											
PCDHA12	56137	broad.mit.edu	37	chr5	140256671	140256671	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagttccaggtgagcgcgcgCgacgccggcgtgccgcctct	15	16	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr5:140256671C>T	uc003lic.2	+	1	1741	c.1614C>T	c.(1612-1614)CGC>CGT	p.R538R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.R538R	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	538	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGCGCGCGCGACGCCGGCG	0.692													T	140256671	T	T	140256671	2	4	73	1	0	0	0	0	0	0	0	1	11522	755	27	1		1	PCDHA12	5	140256671	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	113370721	140256671	40658589	30	4883											
PPP2R2B	5521	broad.mit.edu	37	chr5	146030195	146030195	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtttcatagtcgctgttgacAgatatggagttgatgtgata	12	4	1	4	rs146742970	byFrequency	TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr5:146030195A>T	uc003loe.2	-	5	1065	c.540T>A	c.(538-540)TCT>TCA	p.S180S	PPP2R2B_uc010jgm.2_Silent_p.S169S|PPP2R2B_uc003log.3_Silent_p.S180S|PPP2R2B_uc003lof.3_Silent_p.S180S|PPP2R2B_uc003loi.3_Silent_p.S183S|PPP2R2B_uc003loh.3_Silent_p.S180S|PPP2R2B_uc003loj.3_Silent_p.S160S|PPP2R2B_uc003lok.3_Silent_p.S169S|PPP2R2B_uc011dbu.1_Silent_p.S186S|PPP2R2B_uc011dbv.1_Silent_p.S238S	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	180	WD 3.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGCTGTTGACAGATATGGAGT	0.458													T	146030195	T	T	146030195	2	4	73	1	0	0	0	0	0	0	0	1	12385	175	7	5		5	PPP2R2B	5	146030195	Silent	SNP	A	TCGA-06-1804-01A-01D-1696-08	5773524	146030195	34885065	31	4884											
FAM71B	153745	broad.mit.edu	37	chr5	156589483	156589483	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggatttggtttcaaagacgAtcatctccgtcttctcggat	9	9	5	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr5:156589483A>G	uc003lwn.2	-	2	1893	c.1793T>C	c.(1792-1794)ATC>ACC	p.I598T		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	598						nucleus		p.I598I(1)		ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTCAAAGACGATCATCTCCGT	0.517													G	156589483	G	G	156589483	3	3	73	1	0	0	0	0	1	0	0	0	5608	333	12	4	28	4	FAM71B	5	156589483	Missense_Mutation	SNP	A	TCGA-06-1804-01A-01D-1696-08	10559288	156589483	24325777	32	4885											
ABCC10	89845	broad.mit.edu	37	chr6	43403588	43403588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggccaaagtgtccttggacCggatccagcttttcctcgac	10	13	0	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr6:43403588C>T	uc003ouy.1	+	5	1923	c.1708C>T	c.(1708-1710)CGG>TGG	p.R570W	ABCC10_uc003ouz.1_Missense_Mutation_p.R527W|ABCC10_uc010jyo.1_5'UTR	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	570						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GTCCTTGGACCGGATCCAGCT	0.567													T	43403588	T	T	43403588	3	4	73	1	0	0	0	0	1	0	0	0	50	643	23	2	1589	2	ABCC10	6	43403588	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08		43403588	127711479	33	4886											
PKHD1	5314	broad.mit.edu	37	chr6	51523897	51523897	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgataaggatgaaatcattCcagtgctccttactgttggc	9	8	1	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr6:51523897C>T	uc003pah.1	-	61	11303	c.11027G>A	c.(11026-11028)GGA>GAA	p.G3676E		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3676	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TGAAATCATTCCAGTGCTCCT	0.403													T	51523897	T	T	51523897	3	4	73	1	0	0	0	0	1	0	0	0	11971	855	30	3	1225	3	PKHD1	6	51523897	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	8120309	51523897	119591170	34	4887											
ZNF292	23036	broad.mit.edu	37	chr6	87865454	87865454	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cggccgtggaagcggccaccGactactgtcagcagctgtgc	14	14	1	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr6:87865454G>T	uc003plm.3	+	1	186	c.145G>T	c.(145-147)GAC>TAC	p.D49Y	ZNF292_uc003plk.2_RNA|ZNF292_uc003pll.1_Missense_Mutation_p.D49Y	NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	49					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		AGCGGCCACCGACTACTGTCA	0.726													T	87865454	T	T	87865454	3	4	73	1	0	0	0	0	1	0	0	0	17823	1058	37	5	147	5	ZNF292	6	87865454	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	36341557	87865454	83249613	35	4888											
GPR6	2830	broad.mit.edu	37	chr6	110300407	110300407	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccacagcagcaggggggcCggacacgggcgaatggggac	20	11	0	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr6:110300407C>T	uc011eaw.1	+	2	272	c.92C>T	c.(91-93)CCG>CTG	p.P31L	GPR6_uc011eav.1_Missense_Mutation_p.P46L|GPR6_uc003ptu.2_Missense_Mutation_p.P31L	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	31	Extracellular (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		gcaggggggccggACACGGGC	0.502													T	110300407	T	T	110300407	3	4	73	1	0	0	0	0	1	0	0	0	6701	652	23	2	94	2	GPR6	6	110300407	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	22434953	110300407	60814660	36	4889											
EGFR	1956	broad.mit.edu	37	chr7	55221722	55221722	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aggtctgccgcaaattccgaGacgaagccacgtgcaaggac	12	12	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr7:55221722G>T	uc003tqk.2	+	7	1012	c.766G>T	c.(766-768)GAC>TAC	p.D256Y	EGFR_uc003tqh.2_Missense_Mutation_p.D256Y|EGFR_uc003tqi.2_Missense_Mutation_p.D256Y|EGFR_uc003tqj.2_Missense_Mutation_p.D256Y|EGFR_uc010kzg.1_Missense_Mutation_p.D211Y|EGFR_uc011kco.1_Missense_Mutation_p.D203Y|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	256	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.D256A(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAAATTCCGAGACGAAGCCAC	0.582		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221722	T	T	55221722	3	4	73	1	0	0	0	0	1	0	0	0	4967	942	33	5	792	5	EGFR	7	55221722	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08		55221722	103916941	37	4890											
MYL10	93408	broad.mit.edu	37	chr7	101256837	101256837	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacatctgggggaaatgctGcaaacatctgcttgacctga	10	10	2	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr7:101256837G>A	uc003uyr.2	-	8	777	c.599C>T	c.(598-600)GCA>GTA	p.A200V		NM_138403	NP_612412	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	200	EF-hand 3.					mitochondrion	calcium ion binding			ovary(1)|breast(1)	2						GGGAAATGCTGCAAACATCTG	0.562													A	101256837	A	A	101256837	3	1	73	1	0	0	0	0	1	0	0	0	10044	1319	46	3	85	3	MYL10	7	101256837	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	46035115	101256837	57881826	38	4891											
PTPRZ1	5803	broad.mit.edu	37	chr7	121653409	121653409	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atgacagaggtagtgatggcTtatccattcataagtgtatg	11	5	1	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr7:121653409T>A	uc003vjy.2	+	12	4704	c.4309T>A	c.(4309-4311)TTA>ATA	p.L1437I	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1437	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TAGTGATGGCTTATCCATTCA	0.308													A	121653409	A	A	121653409	3	1	73	1	0	0	0	0	1	0	0	0	12814	1606	56	5	4355	5	PTPRZ1	7	121653409	Missense_Mutation	SNP	T	TCGA-06-1804-01A-01D-1696-08	20396572	121653409	37485254	39	4892											
UBE3C	9690	broad.mit.edu	37	chr7	157046771	157046771	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagcactgcctggctttcCgccagggccttgccaatgtc	11	16	0	0	rs142140245		TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr7:157046771C>T	uc010lqs.2	+	20	3130	c.2818C>T	c.(2818-2820)CGC>TGC	p.R940C	UBE3C_uc003wni.3_Missense_Mutation_p.R303C	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	940	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		CCTGGCTTTCCGCCAGGGCCT	0.562													T	157046771	T	T	157046771	3	4	73	1	0	0	0	0	1	0	0	0	16878	652	23	2	2896	2	UBE3C	7	157046771	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	35393362	157046771	2091892	40	4893											
ADAM28	10863	broad.mit.edu	37	chr8	24200682	24200682	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accaattgctcatctaagtgCaaaggacatgctgtaagttc	8	9	2	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr8:24200682C>A	uc003xdy.2	+	17	1982	c.1899C>A	c.(1897-1899)TGC>TGA	p.C633*	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Nonsense_Mutation_p.C320*	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	633	EGF-like.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CATCTAAGTGCAAAGGACATG	0.358													A	24200682	A	A	24200682	4	1	73	1	0	0	0	0	0	1	0	0	246	718	25	5	2021	5	ADAM28	8	24200682	Nonsense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08		24200682	122163340	41	4894											
DOCK5	80005	broad.mit.edu	37	chr8	25203034	25203034	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgacagaccagctcagCggccagttagatgacaactc	10	13	1	4			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr8:25203034C>T	uc003xeg.2	+	26	2798	c.2661C>T	c.(2659-2661)AGC>AGT	p.S887S	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Silent_p.S601S|DOCK5_uc003xei.2_Silent_p.S457S|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	887						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		ACCAGCTCAGCGGCCAGTTAG	0.557													T	25203034	T	T	25203034	2	4	73	1	0	0	0	0	0	0	0	1	4690	767	27	1		1	DOCK5	8	25203034	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	1002352	25203034	121160988	42	4895											
TGS1	96764	broad.mit.edu	37	chr8	56699365	56699365	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcttcacctattatggttgAtaatgatagctctggtacaa	7	7	3	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr8:56699365A>G	uc003xsj.3	+	4	1295	c.908A>G	c.(907-909)GAT>GGT	p.D303G	TGS1_uc010lyh.2_Missense_Mutation_p.D207G	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	303					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			ATTATGGTTGATAATGATAGC	0.333													G	56699365	G	G	56699365	3	3	73	1	0	0	0	0	1	0	0	0	15834	333	12	4	922	4	TGS1	8	56699365	Missense_Mutation	SNP	A	TCGA-06-1804-01A-01D-1696-08	31496331	56699365	89664657	43	4896											
SYBU	55638	broad.mit.edu	37	chr8	110588241	110588241	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	aagctccacgatttcactttCcctagagtgccaagacaagc	7	13	1	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr8:110588241C>A	uc003ynj.3	-	7	1049	c.886G>T	c.(886-888)GAA>TAA	p.E296*	SYBU_uc003yni.3_Nonsense_Mutation_p.E293*|SYBU_uc003ynk.3_Nonsense_Mutation_p.E177*|SYBU_uc010mco.2_Nonsense_Mutation_p.E295*|SYBU_uc003ynl.3_Nonsense_Mutation_p.E295*|SYBU_uc010mcp.2_Nonsense_Mutation_p.E296*|SYBU_uc010mcq.2_Nonsense_Mutation_p.E296*|SYBU_uc003yno.3_Nonsense_Mutation_p.E177*|SYBU_uc010mcr.2_Nonsense_Mutation_p.E296*|SYBU_uc003ynm.3_Nonsense_Mutation_p.E295*|SYBU_uc003ynn.3_Nonsense_Mutation_p.E295*|SYBU_uc010mcs.2_Nonsense_Mutation_p.E177*|SYBU_uc010mct.2_Nonsense_Mutation_p.E296*|SYBU_uc010mcu.2_Nonsense_Mutation_p.E295*|SYBU_uc003ynp.3_Nonsense_Mutation_p.E228*|SYBU_uc010mcv.2_Nonsense_Mutation_p.E296*|SYBU_uc003ynh.3_Nonsense_Mutation_p.E90*|SYBU_uc011lhw.1_Nonsense_Mutation_p.E166*	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	296	Potential.|Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						ATTTCACTTTCCCTAGAGTGC	0.463													A	110588241	A	A	110588241	4	1	73	1	0	0	0	0	0	1	0	0	15424	869	30	5	1109	5	SYBU	8	110588241	Nonsense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	53888876	110588241	35775781	44	4897											
RFX3	5991	broad.mit.edu	37	chr9	3225104	3225104	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatagtctgagtacttgtgaCaatgtgctcgctgtgaattg	12	6	1	3	rs137899630	byFrequency	TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr9:3225104C>T	uc003zhr.2	-	18	2500	c.2188G>A	c.(2188-2190)GTC>ATC	p.V730I	RFX3_uc010mhd.2_Missense_Mutation_p.V730I	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	730					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		GTACTTGTGACAATGTGCTCG	0.478													T	3225104	T	T	3225104	3	4	73	1	0	0	0	0	1	0	0	0	13264	478	17	3	65	3	RFX3	9	3225104	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08		3225104	137988327	45	4898											
FLJ46321	389763	broad.mit.edu	37	chr9	84609494	84609494	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acccagcatatcatatgaagAacaagaaagttcctgggaaa	8	8	1	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr9:84609494A>G	uc004amn.2	+	4	4156	c.4109A>G	c.(4108-4110)GAA>GGA	p.E1370G		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1370						integral to membrane					0						TCATATGAAGAACAAGAAAGT	0.433													G	84609494	G	G	84609494	3	3	73	1	0	0	0	0	1	0	0	0	5932	246	9	4	4123	4	FLJ46321	9	84609494	Missense_Mutation	SNP	A	TCGA-06-1804-01A-01D-1696-08	81384390	84609494	56603937	46	4899											
CACNA1B	774	broad.mit.edu	37	chr9	140904511	140904511	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgtggacaacctggccaaCgcccaagagctgaccaaggt	12	13	0	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr9:140904511C>T	uc004cog.2	+	17	2287	c.2142C>T	c.(2140-2142)AAC>AAT	p.N714N	CACNA1B_uc011mfd.1_Silent_p.N245N	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	714	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	ACCTGGCCAACGCCCAAGAGC	0.607													T	140904511	T	T	140904511	2	4	73	1	0	0	0	0	0	0	0	1	2539	535	19	1		1	CACNA1B	9	140904511	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	56295017	140904511	308920	47	4900											
MYO3A	53904	broad.mit.edu	37	chr10	26305807	26305807	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacacatccgtaggaacaccGttttggatggctcctgaggt	11	10	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr10:26305807G>A	uc001isn.2	+	7	927	c.567G>A	c.(565-567)CCG>CCA	p.P189P	MYO3A_uc009xko.1_Silent_p.P189P|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Silent_p.P189P|MYO3A_uc001ism.2_Silent_p.P189P	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	189	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TAGGAACACCGTTTTGGATGG	0.448													A	26305807	A	A	26305807	2	1	73	1	0	0	0	0	0	0	0	1	10076	1132	40	1		1	MYO3A	10	26305807	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08		26305807	109228940	48	4901											
PTEN	5728	broad.mit.edu	37	chr10	89653833	89653833	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctgcagaaagacttgaagGcgtatacaggaacaatattg	10	7	0	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr10:89653833G>A	uc001kfb.2	+	3	1162	c.131G>A	c.(130-132)GGC>GAC	p.G44D		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	44	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(4)|p.G44G(3)|p.Y27fs*1(2)|p.G44D(2)|p.Y27_N212>Y(2)|p.G44fs*8(1)|p.G44fs*11(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGACTTGAAGGCGTATACAGG	0.294		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89653833	A	A	89653833	3	1	73	1	0	0	0	0	1	0	0	0	12738	1203	42	3	137	3	PTEN	10	89653833	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	63348026	89653833	45880914	49	4902											
NLRP6	171389	broad.mit.edu	37	chr11	285212	285212	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agtcactacaggagcttcagGctgtgaagagagcaaagccg	13	9	2	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:285212G>T	uc010qvs.1	+	8	2587	c.2587G>T	c.(2587-2589)GCT>TCT	p.A863S	NLRP6_uc010qvt.1_Missense_Mutation_p.A862S	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	863	LRR 5.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		GGAGCTTCAGGCTGTGAAGAG	0.617													T	285212	T	T	285212	3	4	73	1	0	0	0	0	1	0	0	0	10481	1203	42	5	2617	5	NLRP6	11	285212	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08		285212	134721304	50	4903											
OR51A2	401667	broad.mit.edu	37	chr11	4976634	4976634	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgagaatccatgaatgaagaAttcctgggcaaagcaggcac	11	8	0	4			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:4976634A>T	uc010qyt.1	-	1	310	c.310T>A	c.(310-312)TTC>ATC	p.F104I		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAATGAAGAATTCCTGGGCA	0.448													T	4976634	T	T	4976634	3	4	73	1	0	0	0	0	1	0	0	0	11086	101	4	5	633	5	OR51A2	11	4976634	Missense_Mutation	SNP	A	TCGA-06-1804-01A-01D-1696-08	4691422	4976634	130029882	51	4904											
OR52E2	119678	broad.mit.edu	37	chr11	5080295	5080295	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgatgctggcacaagatagaTgagcaagacccatgtgctca	11	9	1	5			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:5080295T>C	uc010qyw.1	-	1	563	c.563A>G	c.(562-564)CAT>CGT	p.H188R		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		ACAAGATAGATGAGCAAGACC	0.388													C	5080295	C	C	5080295	3	2	73	1	0	0	0	0	1	0	0	0	11115	1464	51	4	417	4	OR52E2	11	5080295	Missense_Mutation	SNP	T	TCGA-06-1804-01A-01D-1696-08	103661	5080295	129926221	52	4905											
PAX6	5080	broad.mit.edu	37	chr11	31824337	31824337	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggtggagtccggcagtggcCgcccgttgacaaagacacca	15	12	0	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:31824337C>A	uc001mtd.3	-	4	946	c.56G>T	c.(55-57)CGG>CTG	p.R19L	PAX6_uc001mte.3_Missense_Mutation_p.R19L|PAX6_uc001mtg.3_Missense_Mutation_p.R19L|PAX6_uc001mtf.3_Missense_Mutation_p.R19L|PAX6_uc001mth.3_Missense_Mutation_p.R19L|PAX6_uc009yjr.2_Missense_Mutation_p.R19L	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	19	Paired.		R -> P (in AN).		blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					CGGCAGTGGCCGCCCGTTGAC	0.498									Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				A	31824337	A	A	31824337	3	1	73	1	0	0	0	0	1	0	0	0	11483	652	23	5	1294	5	PAX6	11	31824337	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	26744042	31824337	103182179	53	4906											
OR4D6	219983	broad.mit.edu	37	chr11	59224437	59224437	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agagagtcatccccatcatgGaccagatcaaccacactaat	6	13	3	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:59224437G>T	uc010rku.1	+	1	4	c.4G>T	c.(4-6)GAC>TAC	p.D2Y		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCCCATCATGGACCAGATCAA	0.423													T	59224437	T	T	59224437	3	4	73	1	0	0	0	0	1	0	0	0	11058	1174	41	5	6	5	OR4D6	11	59224437	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	27400100	59224437	75782079	54	4907											
MS4A8B	83661	broad.mit.edu	37	chr11	60470943	60470943	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacctgtctatttcattctaCggaggctttcccttctgggg	9	11	4	0	rs144254483		TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:60470943C>T	uc001npv.2	+	3	515	c.312C>T	c.(310-312)TAC>TAT	p.Y104Y	MS4A8B_uc009yne.1_Silent_p.Y104Y	NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	104	Helical; (Potential).					integral to membrane	receptor activity				0						TTTCATTCTACGGAGGCTTTC	0.567													T	60470943	T	T	60470943	2	4	73	1	0	0	0	0	0	0	0	1	9867	547	19	1		1	MS4A8B	11	60470943	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	1246506	60470943	74535573	55	4908											
CD6	923	broad.mit.edu	37	chr11	60739382	60739382	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggattgctgacggcagccctCtcaggtaggcccccttccct	11	16	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:60739382C>A	uc001nqq.2	+	1	268	c.45C>A	c.(43-45)CTC>CTA	p.L15L	CD6_uc009yni.2_Silent_p.L15L|CD6_uc009ynj.2_Silent_p.L15L|CD6_uc001nqp.2_Silent_p.L15L|CD6_uc001nqr.2_Silent_p.L15L|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Silent_p.L15L	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	15					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						CGGCAGCCCTCTCAGGTAGGC	0.602													A	60739382	A	A	60739382	2	1	73	1	0	0	0	0	0	0	0	1	3028	900	32	5		5	CD6	11	60739382	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	268439	60739382	74267134	56	4909											
DDB1	1642	broad.mit.edu	37	chr11	61079499	61079499	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggaactgtgcgaatgtgcagCttctggatctcatcgatggt	13	8	2	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:61079499C>G	uc001nrc.3	-	17	2353	c.2127G>C	c.(2125-2127)AAG>AAC	p.K709N	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Missense_Mutation_p.K709N	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	709	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						GAATGTGCAGCTTCTGGATCT	0.547								NER					G	61079499	G	G	61079499	3	3	73	1	0	0	0	0	1	0	0	0	4323	796	28	5	1339	5	DDB1	11	61079499	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	340117	61079499	73927017	57	4910											
NPAS4	266743	broad.mit.edu	37	chr11	66190325	66190325	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagaccccgcccaggtcctgGccctggccctggccctgcct	12	20	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:66190325G>A	uc001ohx.1	+	4	787	c.611G>A	c.(610-612)GGC>GAC	p.G204D	NPAS4_uc010rpc.1_Missense_Mutation_p.A31T	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	204	PAS 2.				transcription, DNA-dependent		DNA binding|signal transducer activity				0						CCAGGTCCTGGCCCTGGCCCT	0.632													A	66190325	A	A	66190325	3	1	73	1	0	0	0	0	1	0	0	0	10565	1203	42	3	625	3	NPAS4	11	66190325	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	5110826	66190325	68816191	58	4911											
ODZ4	26011	broad.mit.edu	37	chr11	78380034	78380034	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ctgatggggttgttgtttttGaacatatagagattaaaagg	12	2	0	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:78380034G>C	uc001ozl.3	-	32	7819	c.7356C>G	c.(7354-7356)TTC>TTG	p.F2452L	ODZ4_uc001ozk.3_Missense_Mutation_p.F677L|ODZ4_uc009yvb.1_Missense_Mutation_p.F1036L	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2452	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TGTTGTTTTTGAACATATAGA	0.507													C	78380034	C	C	78380034	3	2	73	1	0	0	0	0	1	0	0	0	10837	1281	45	5	965	5	ODZ4	11	78380034	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	12189709	78380034	56626482	59	4912											
FOLH1B	219595	broad.mit.edu	37	chr11	89405127	89405127	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgaccctcagagtggagcagCtgttgttcatgaaactgtga	12	8	2	4			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr11:89405127C>G	uc001pda.2	+	5	780	c.254C>G	c.(253-255)GCT>GGT	p.A85G		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	85					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						AGTGGAGCAGCTGTTGTTCAT	0.368													G	89405127	G	G	89405127	3	3	73	1	0	0	0	0	1	0	0	0	5980	797	28	5	264	5	FOLH1B	11	89405127	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	11025093	89405127	45601389	60	4913											
ERC1	23085	broad.mit.edu	37	chr12	1291107	1291107	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaggagcggacaattgaacGcttaaaggagcagagggaca	14	7	1	2	rs138512011	byFrequency	TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr12:1291107G>A	uc001qjb.2	+	10	2133	c.1892G>A	c.(1891-1893)CGC>CAC	p.R631H	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.R603H|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Missense_Mutation_p.R631H|ERC1_uc010sdv.1_Missense_Mutation_p.R379H|ERC1_uc009zdp.2_Missense_Mutation_p.R271H	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	631	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			ACAATTGAACGCTTAAAGGAG	0.378													A	1291107	A	A	1291107	3	1	73	1	0	0	0	0	1	0	0	0	5210	1087	38	1	1926	1	ERC1	12	1291107	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08		1291107	132560788	61	4914											
FOXJ2	55810	broad.mit.edu	37	chr12	8192492	8192492	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccccagctgaccctccgaGctaccattgagaagcttgga	9	15	0	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr12:8192492G>A	uc001qtu.2	+	2	1149	c.64G>A	c.(64-66)GCT>ACT	p.A22T	FOXJ2_uc001qtt.1_Missense_Mutation_p.A22T	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	22					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)		GACCCTCCGAGCTACCATTGA	0.582													A	8192492	A	A	8192492	3	1	73	1	0	0	0	0	1	0	0	0	6012	971	34	3	66	3	FOXJ2	12	8192492	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	6901385	8192492	125659403	62	4915											
C12orf35	55196	broad.mit.edu	37	chr12	32138039	32138039	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tagaccaagggaacgtattaGatatggaagtaaagaaaaag	11	3	0	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr12:32138039G>C	uc001rks.2	+	4	4564	c.4150G>C	c.(4150-4152)GAT>CAT	p.D1384H	C12orf35_uc001rkt.2_5'Flank	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1384										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			GAACGTATTAGATATGGAAGT	0.343													C	32138039	C	C	32138039	3	2	73	1	0	0	0	0	1	0	0	0	1682	942	33	5	4152	5	C12orf35	12	32138039	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	23945547	32138039	101713856	63	4916											
LARP4	113251	broad.mit.edu	37	chr12	50831593	50831593	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gcgttgtattgtaattcttaGagagattcctgaaacaacac	8	7	1	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr12:50831593G>A	uc001rwp.1	+	6	755	c.611G>A	c.(610-612)AGA>AAA	p.R204K	LARP4_uc001rwo.1_Missense_Mutation_p.R210K|LARP4_uc001rwq.1_Missense_Mutation_p.R204K|LARP4_uc001rwr.1_Missense_Mutation_p.R204K|LARP4_uc001rws.1_Missense_Mutation_p.R203K|LARP4_uc009zlr.1_Missense_Mutation_p.R23K|LARP4_uc001rwm.2_Missense_Mutation_p.R204K|LARP4_uc001rwn.2_Missense_Mutation_p.R134K	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	204	RRM.						nucleotide binding|RNA binding			ovary(1)	1						GTAATTCTTAGAGAGATTCCT	0.338													A	50831593	A	A	50831593	3	1	73	1	0	0	0	0	1	0	0	0	8630	942	33	3	633	3	LARP4	12	50831593	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	18693554	50831593	83020302	64	4917											
C12orf63	374467	broad.mit.edu	37	chr12	97052014	97052014	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtatacagaacaagtgacaCcacttctggtgtatgcacag	10	9	1	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr12:97052014C>A	uc001tet.1	+	5	703	c.625C>A	c.(625-627)CCA>ACA	p.P209T		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	209										skin(6)|ovary(1)	7						ACAAGTGACACCACTTCTGGT	0.388													A	97052014	A	A	97052014	3	1	73	1	0	0	0	0	1	0	0	0	1706	507	18	5	639	5	C12orf63	12	97052014	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	46220421	97052014	36799881	65	4918											
CHD8	57680	broad.mit.edu	37	chr14	21876716	21876716	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agccaggatgcagttctgccTgcagattcaccatgggaaaa	11	10	2	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr14:21876716T>C	uc001was.1	-	13	1744	c.1650_splice	c.e13-1	p.R550_splice	CHD8_uc001war.1_Splice_Site_p.R446_splice|CHD8_uc001wav.1_Splice_Site	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8						ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CAGTTCTGCCTGCAGATTCAC	0.353													C	21876716	C	C	21876716	5	2	73	1	0	0	0	0	0	0	1	0	3331	1594	55	4	5364	4	CHD8	14	21876716	Splice_Site	SNP	T	TCGA-06-1804-01A-01D-1696-08		21876716	85472824	66	4919											
LRRC16B	90668	broad.mit.edu	37	chr14	24538046	24538046	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaagccagtggctgtgcccAggggccgccagcctccccag	13	18	0	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr14:24538046A>G	uc001wlj.2	+	38	4010	c.3853A>G	c.(3853-3855)AGG>GGG	p.R1285G	LRRC16B_uc001wlk.2_Missense_Mutation_p.R338G|CPNE6_uc010tnv.1_5'Flank|CPNE6_uc001wlm.2_5'Flank|CPNE6_uc001wll.2_5'Flank	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1285										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		GGCTGTGCCCAGGGGCCGCCA	0.637													G	24538046	G	G	24538046	3	3	73	1	0	0	0	0	1	0	0	0	8972	179	7	4	4003	4	LRRC16B	14	24538046	Missense_Mutation	SNP	A	TCGA-06-1804-01A-01D-1696-08	2661330	24538046	82811494	67	4920											
KIAA0284	283638	broad.mit.edu	37	chr14	105353636	105353636	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacttggcccgacggacatGggccgtggagagccggtacg	16	13	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr14:105353636G>A	uc010axb.2	+	12	3284	c.3060G>A	c.(3058-3060)ATG>ATA	p.M1020I	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.M950I|KIAA0284_uc001yps.2_Missense_Mutation_p.M926I|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1020						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		CGACGGACATGGGCCGTGGAG	0.701													A	105353636	A	A	105353636	3	1	73	1	0	0	0	0	1	0	0	0	8166	1348	47	3	3102	3	KIAA0284	14	105353636	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	80815590	105353636	1995904	68	4921											
UNKL	64718	broad.mit.edu	37	chr16	1417320	1417320	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acgggcacgctccttggcctCctgcgcctctcgctgccagg	12	18	1	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr16:1417320C>T	uc010brn.1	-	8	958	c.940G>A	c.(940-942)GAG>AAG	p.E314K	UNKL_uc002cln.2_Missense_Mutation_p.E106K|UNKL_uc002clo.2_Missense_Mutation_p.E103K|UNKL_uc002clp.2_Missense_Mutation_p.E106K			Q9H9P5	UNKL_HUMAN	SubName: Full=Putative ubiquitin-protein ligase;          EC=6.3.2.19; Flags: Fragment;	604	Potential.					cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				TCCTTGGCCTCCTGCGCCTCT	0.667													T	1417320	T	T	1417320	3	4	73	1	0	0	0	0	1	0	0	0	16998	864	30	3	390	3	UNKL	16	1417320	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08		1417320	88937433	69	4922											
ABCA3	21	broad.mit.edu	37	chr16	2369841	2369841	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaagccttcccggatgtacCctgggtgcgggagcagagga	17	10	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr16:2369841C>T	uc002cpy.1	-	8	1326	c.614G>A	c.(613-615)GGG>GAG	p.G205E	ABCA3_uc010bsk.1_Missense_Mutation_p.G205E|ABCA3_uc010bsl.1_Missense_Mutation_p.G205E	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	205					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CCGGATGTACCCTGGGTGCGG	0.657													T	2369841	T	T	2369841	3	4	73	1	0	0	0	0	1	0	0	0	33	637	22	3	4604	3	ABCA3	16	2369841	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	952521	2369841	87984912	70	4923											
GRIN2A	2903	broad.mit.edu	37	chr16	10274212	10274212	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgcgctcggcgccggaccGcgccagaccagaagggccgg	17	17	0	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr16:10274212G>A	uc002czo.3	-	2	605	c.57C>T	c.(55-57)CGC>CGT	p.R19R	GRIN2A_uc010uym.1_Silent_p.R19R|GRIN2A_uc002czr.3_Silent_p.R19R|GRIN2A_uc010buk.2_Silent_p.R19R	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	19					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCGCCGGACCGCGCCAGACCA	0.657													A	10274212	A	A	10274212	2	1	73	1	0	0	0	0	0	0	0	1	6779	1074	38	1		1	GRIN2A	16	10274212	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08	7904371	10274212	80080541	71	4924											
GGA2	23062	broad.mit.edu	37	chr16	23505700	23505700	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagggcgcatgtgtggggCtacagggaaacaaaaagacc	15	9	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr16:23505700C>T	uc002dlq.2	-	3	253	c.177_splice	c.e3-1	p.G59_splice	GGA2_uc010bxo.1_Splice_Site	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2						intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		ATGTGTGGGGCTACAGGGAAA	0.522													T	23505700	T	T	23505700	5	4	73	1	0	0	0	0	0	0	1	0	6353	811	28	3	1725	3	GGA2	16	23505700	Splice_Site	SNP	C	TCGA-06-1804-01A-01D-1696-08	13231488	23505700	66849053	72	4925											
CETP	1071	broad.mit.edu	37	chr16	57017290	57017290	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agcaaaggcgtgagcctcttCgacatcatcaaccctgagat	9	12	3	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr16:57017290C>T	uc002eki.2	+	15	1431	c.1374C>T	c.(1372-1374)TTC>TTT	p.F458F	CETP_uc002ekj.2_Silent_p.F398F	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	458					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						TGAGCCTCTTCGACATCATCA	0.592													T	57017290	T	T	57017290	2	4	73	1	0	0	0	0	0	0	0	1	3277	883	31	2		2	CETP	16	57017290	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	33511590	57017290	33337463	73	4926											
GPR114	221188	broad.mit.edu	37	chr16	57609404	57609404	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgccgctcagaagcagaggCcaaggcacagatagaggcct	14	11	1	4			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr16:57609404C>T	uc002elx.3	+	12	1626	c.1541C>T	c.(1540-1542)GCC>GTC	p.A514V	GPR114_uc010vhr.1_3'UTR|GPR114_uc002ely.2_Missense_Mutation_p.A514V	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	514	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						GAAGCAGAGGCCAAGGCACAG	0.612													T	57609404	T	T	57609404	3	4	73	1	0	0	0	0	1	0	0	0	6631	739	26	3	1583	3	GPR114	16	57609404	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	592114	57609404	32745349	74	4927											
SPDYE4	388333	broad.mit.edu	37	chr17	8658884	8658884	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtattgccacgagaagaggcCggcacggctaaaatacgcta	12	10	0	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr17:8658884C>T	uc010cnz.1	-	4	616	c.439G>A	c.(439-441)GGC>AGC	p.G147S		NM_001128076	NP_001121548	A6NLX3	SPDE4_HUMAN	speedy homolog E4	147											0						GAGAAGAGGCCGGCACGGCTA	0.493													T	8658884	T	T	8658884	3	4	73	1	0	0	0	0	1	0	0	0	15030	652	23	2	286	2	SPDYE4	17	8658884	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08		8658884	72536326	75	4928											
PIK3R5	23533	broad.mit.edu	37	chr17	8784088	8784088	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcttctctggcttgtagcaCggtgagacctcacatctgtg	10	12	4	1	rs141893152	byFrequency	TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr17:8784088C>T	uc002glt.2	-	19	2578	c.2511G>A	c.(2509-2511)CCG>CCA	p.P837P	PIK3R5_uc010vuz.1_Silent_p.P837P|PIK3R5_uc002glu.3_Silent_p.P451P	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	837					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GCTTGTAGCACGGTGAGACCT	0.647													T	8784088	T	T	8784088	2	4	73	1	0	0	0	0	0	0	0	1	11922	523	19	1		1	PIK3R5	17	8784088	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	125204	8784088	72411122	76	4929											
KCNJ12	3768	broad.mit.edu	37	chr17	21318735	21318735	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctggtcaccatgtcgggCgccaacggcttcggcaacgg	13	15	1	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr17:21318735C>T	uc002gyv.1	+	3	786	c.81C>T	c.(79-81)GGC>GGT	p.G27G		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	27	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCATGTCGGGCGCCAACGGCT	0.657										Prostate(3;0.18)			T	21318735	T	T	21318735	2	4	73	1	0	0	0	0	0	0	0	1	8046	755	27	1		1	KCNJ12	17	21318735	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	12534647	21318735	59876475	77	4930											
ERN1	2081	broad.mit.edu	37	chr17	62144066	62144066	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctctgtctccttggggaaCgggtacttccactttgtgat	11	11	2	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr17:62144066C>T	uc002jdz.2	-	8	920	c.807G>A	c.(805-807)CCG>CCA	p.P269P		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	269	Lumenal (Potential).				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						CCTTGGGGAACGGGTACTTCC	0.592													T	62144066	T	T	62144066	2	4	73	1	0	0	0	0	0	0	0	1	5237	523	19	1		1	ERN1	17	62144066	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	40825331	62144066	19051144	78	4931											
SLC16A5	9121	broad.mit.edu	37	chr17	73096774	73096774	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctactgcctggcgtacaGcgtgtccatgagtggcatcg	15	11	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr17:73096774G>A	uc002jmr.2	+	5	1388	c.1016G>A	c.(1015-1017)AGC>AAC	p.S339N	SLC16A5_uc002jms.1_Missense_Mutation_p.S339N|SLC16A5_uc002jmt.2_Missense_Mutation_p.S339N|SLC16A5_uc002jmu.2_Missense_Mutation_p.S339N|SLC16A5_uc010wrt.1_Missense_Mutation_p.S379N	NM_004695	NP_004686	O15375	MOT6_HUMAN	solute carrier family 16, member 5	339	Helical; (Potential).				organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	CTGGCGTACAGCGTGTCCATG	0.592													A	73096774	A	A	73096774	3	1	73	1	0	0	0	0	1	0	0	0	14411	971	34	3	1026	3	SLC16A5	17	73096774	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	10952708	73096774	8098436	79	4932											
ENGASE	64772	broad.mit.edu	37	chr17	77081747	77081747	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgcctgctgctagacctcctCgtttgcttctcacggccgcc	9	17	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr17:77081747C>T	uc002jwv.2	+	13	1754	c.1746C>T	c.(1744-1746)CTC>CTT	p.L582L	ENGASE_uc002jww.2_Silent_p.L287L	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	582						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						TAGACCTCCTCGTTTGCTTCT	0.662													T	77081747	T	T	77081747	2	4	73	1	0	0	0	0	0	0	0	1	5118	871	31	2		2	ENGASE	17	77081747	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	3984973	77081747	4113463	80	4933											
CCDC68	80323	broad.mit.edu	37	chr18	52604167	52604167	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgtttctcagagctgctgctCctgcttctctggaggcttgc	11	13	2	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr18:52604167C>T	uc002lfs.2	-	6	540	c.368G>A	c.(367-369)GGA>GAA	p.G123E	CCDC68_uc002lft.2_Missense_Mutation_p.G123E	NM_001143829	NP_001137301	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	123	Potential.									skin(1)	1				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		AGCTGCTGCTCCTGCTTCTCT	0.418													T	52604167	T	T	52604167	3	4	73	1	0	0	0	0	1	0	0	0	2840	855	30	3	667	3	CCDC68	18	52604167	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08		52604167	25473081	81	4934											
DOK6	220164	broad.mit.edu	37	chr18	67365777	67365777	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggtgatgtggcctctcagcTcactgaggagatacggtcgg	15	9	2	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr18:67365777T>A	uc002lkl.2	+	5	737	c.547T>A	c.(547-549)TCA>ACA	p.S183T		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	183	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GCCTCTCAGCTCACTGAGGAG	0.463													A	67365777	A	A	67365777	3	1	73	1	0	0	0	0	1	0	0	0	4701	1551	54	5	565	5	DOK6	18	67365777	Missense_Mutation	SNP	T	TCGA-06-1804-01A-01D-1696-08	14761610	67365777	10711471	82	4935											
FZR1	51343	broad.mit.edu	37	chr19	3531983	3531983	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctgcagagggacatccgcAccccgccactgcagtcggag	12	16	0	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr19:3531983A>C	uc010dtk.2	+	9	932	c.898A>C	c.(898-900)ACC>CCC	p.T300P	FZR1_uc002lxt.2_Missense_Mutation_p.T300P|FZR1_uc002lxv.2_Missense_Mutation_p.T211P	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	300	WD 3.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACATCCGCACCCCGCCACT	0.711													C	3531983	C	C	3531983	3	2	73	1	0	0	0	0	1	0	0	0	6138	159	6	5	932	5	FZR1	19	3531983	Missense_Mutation	SNP	A	TCGA-06-1804-01A-01D-1696-08		3531983	55597000	83	4936											
ZNF442	79973	broad.mit.edu	37	chr19	12461021	12461021	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccacatttacatttataggGtttctctccagtgtgagttg	8	9	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr19:12461021G>A	uc002mtr.1	-	6	1989	c.1378C>T	c.(1378-1380)CCC>TCC	p.P460S	ZNF442_uc010xmk.1_Missense_Mutation_p.P391S	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						CATTTATAGGGTTTCTCTCCA	0.378													A	12461021	A	A	12461021	3	1	73	1	0	0	0	0	1	0	0	0	17912	1261	44	3	509	3	ZNF442	19	12461021	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	8929038	12461021	46667962	84	4937											
PSG8	440533	broad.mit.edu	37	chr19	43268388	43268388	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggttggctgggcttcaatcGtgacttgggcagtcgtgggt	17	7	1	1	rs142689447		TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr19:43268388G>A	uc002ouo.2	-	2	208	c.110C>T	c.(109-111)ACG>ATG	p.T37M	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Missense_Mutation_p.T37M|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_Translation_Start_Site|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Missense_Mutation_p.T37M|PSG8_uc002oum.3_Missense_Mutation_p.T37M|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.T37M	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	37	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				GGCTTCAATCGTGACTTGGGC	0.463													A	43268388	A	A	43268388	3	1	73	1	0	0	0	0	1	0	0	0	12661	1145	40	1	1207	1	PSG8	19	43268388	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	30807367	43268388	15860595	85	4938											
RTN2	6253	broad.mit.edu	37	chr19	45998164	45998164	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaggagaaggtcagctccCggggggtgccccagtcctgc	16	12	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr19:45998164C>T	uc002pcb.2	-	3	407	c.179G>A	c.(178-180)CGG>CAG	p.R60Q	RTN2_uc002pcc.2_Missense_Mutation_p.R60Q|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	60						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		GGTCAGCTCCCGGGGGGTGCC	0.662													T	45998164	T	T	45998164	3	4	73	1	0	0	0	0	1	0	0	0	13726	652	23	2	1494	2	RTN2	19	45998164	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	2729776	45998164	13130819	86	4939											
TRPM4	54795	broad.mit.edu	37	chr19	49686170	49686170	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctcacccaggccagggcttCggggagagcgtaaggaccgg	16	13	1	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr19:49686170C>T	uc002pmw.2	+	11	1671	c.1599C>T	c.(1597-1599)TTC>TTT	p.F533F	TRPM4_uc010emu.2_Silent_p.F533F|TRPM4_uc010yak.1_Intron|TRPM4_uc002pmx.2_Silent_p.F359F|TRPM4_uc010emv.2_Silent_p.F418F|TRPM4_uc010yal.1_Silent_p.F179F|TRPM4_uc002pmy.2_5'UTR	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	533	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GCCAGGGCTTCGGGGAGAGCG	0.711													T	49686170	T	T	49686170	2	4	73	1	0	0	0	0	0	0	0	1	16585	883	31	2		2	TRPM4	19	49686170	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	3688006	49686170	9442813	87	4940											
SULF2	55959	broad.mit.edu	37	chr20	46318884	46318884	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttacatgtgctgagatgcGtttgggaagaggcgtgaata	15	5	0	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr20:46318884G>A	uc002xto.2	-	5	1053	c.723C>T	c.(721-723)AAC>AAT	p.N241N	SULF2_uc002xtr.2_Silent_p.N241N|SULF2_uc002xtq.2_Silent_p.N241N|SULF2_uc010ghv.1_Silent_p.N241N	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	241					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GCTGAGATGCGTTTGGGAAGA	0.567													A	46318884	A	A	46318884	2	1	73	1	0	0	0	0	0	0	0	1	15370	1136	40	1		1	SULF2	20	46318884	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08		46318884	16706636	88	4941											
HRH3	11255	broad.mit.edu	37	chr20	60791774	60791774	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtgacgctgaggaagggcGtaaagaactccagggtggaa	17	6	0	3			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr20:60791774G>A	uc002ycf.2	-	3	923	c.626C>T	c.(625-627)ACG>ATG	p.T209M	HRH3_uc002ycg.2_Missense_Mutation_p.T209M|HRH3_uc002ych.2_Missense_Mutation_p.T209M|HRH3_uc002yci.2_Missense_Mutation_p.T209M	NM_007232	NP_009163	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	209	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	GAGGAAGGGCGTAAAGAACTC	0.612													A	60791774	A	A	60791774	3	1	73	1	0	0	0	0	1	0	0	0	7357	1145	40	1	715	1	HRH3	20	60791774	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	14472890	60791774	2233746	89	4942											
COL6A2	1292	broad.mit.edu	37	chr21	47535812	47535812	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagggcaacatgggtgagccGggagagcctggccagaaggg	19	8	0	3	rs140790797		TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr21:47535812G>A	uc002zia.1	+	6	910	c.828G>A	c.(826-828)CCG>CCA	p.P276P	COL6A2_uc002zhy.1_Silent_p.P276P|COL6A2_uc002zhz.1_Silent_p.P276P|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	276	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		TGGGTGAGCCGGGAGAGCCTG	0.662													A	47535812	A	A	47535812	2	1	73	1	0	0	0	0	0	0	0	1	3700	1103	39	2		2	COL6A2	21	47535812	Silent	SNP	G	TCGA-06-1804-01A-01D-1696-08		47535812	594083	90	4943											
TRIOBP	11078	broad.mit.edu	37	chr22	38119624	38119624	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagcacccaactggataaccCcagaacctcttctacccagc	5	17	2	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr22:38119624C>A	uc003atr.2	+	7	1332	c.1061C>A	c.(1060-1062)CCC>CAC	p.P354H	TRIOBP_uc003atu.2_Missense_Mutation_p.P182H|TRIOBP_uc003atq.1_Missense_Mutation_p.P354H|TRIOBP_uc003ats.1_Missense_Mutation_p.P182H	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	354					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CTGGATAACCCCAGAACCTCT	0.577													A	38119624	A	A	38119624	3	1	73	1	0	0	0	0	1	0	0	0	16550	623	22	5	1079	5	TRIOBP	22	38119624	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08		38119624	13184942	91	4944											
PNPLA5	150379	broad.mit.edu	37	chr22	44287074	44287074	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggcagagcatcctgcagctgCtgcttgacgtgctcgatggg	15	11	0	2	rs79793310	byFrequency	TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chr22:44287074C>A	uc003beg.2	-	2	391	c.294G>T	c.(292-294)CAG>CAT	p.Q98H	PNPLA5_uc011aqc.1_5'UTR|PNPLA5_uc003beh.2_Intron	NM_138814	NP_620169	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	98	Patatin.				lipid catabolic process		hydrolase activity				0		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				CCTGCAGCTGCTGCTTGACGT	0.662													A	44287074	A	A	44287074	3	1	73	1	0	0	0	0	1	0	0	0	12168	796	28	5	1027	5	PNPLA5	22	44287074	Missense_Mutation	SNP	C	TCGA-06-1804-01A-01D-1696-08	6167450	44287074	7017492	92	4945											
VCX2	51480	broad.mit.edu	37	chrX	8138151	8138151	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tccacctcgctctcctgactCagtggttcttccacctcgct	6	18	3	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chrX:8138151C>T	uc004csb.2	-	3	649	c.342G>A	c.(340-342)CTG>CTA	p.L114L		NM_016378	NP_057462	Q9H322	VCX2_HUMAN	variable charge, X-linked 2	114	2.|2 X 10 AA tandem repeats of L-S-Q-E-S- [EQ]-V-E-E-P.										0		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				TCTCCTGACTCAGTGGTTCTT	0.642													T	8138151	T	T	8138151	2	4	73	1	0	0	0	0	0	0	0	1	17140	813	29	3		3	VCX2	23	8138151	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08		8138151	147132409	93	4946											
PHEX	5251	broad.mit.edu	37	chrX	22112133	22112133	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctttacaagttcatggtggaTactgccgtgcttttaggagc	11	8	1	0			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chrX:22112133T>C	uc004dah.2	+	7	968	c.765T>C	c.(763-765)GAT>GAC	p.D255D	PHEX_uc011mjr.1_Silent_p.D255D|PHEX_uc011mjs.1_Silent_p.D158D	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	255	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						TCATGGTGGATACTGCCGTGC	0.408													C	22112133	C	C	22112133	2	2	73	1	0	0	0	0	0	0	0	1	11819	1403	49	4		4	PHEX	23	22112133	Silent	SNP	T	TCGA-06-1804-01A-01D-1696-08	13973982	22112133	133158427	94	4947											
BCOR	54880	broad.mit.edu	37	chrX	39922999	39923002	+	Frame_Shift_Del	DEL	CTTC	-	-													aggctgagtggcctgggtcaCttccttcctgctttgccggc							TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chrX:39922999_39923002delCTTC	uc004den.3	-	8	3998_4001	c.3706_3709delGAAG	c.(3706-3711)GAAGTGfs	p.E1236fs	BCOR_uc004dep.3_Frame_Shift_Del_p.E1202fs|BCOR_uc004deo.3_Frame_Shift_Del_p.E1184fs|BCOR_uc010nhb.2_5'Flank|BCOR_uc004dem.3_Frame_Shift_Del_p.E1202fs	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1236_1237					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						GCCTGGGTCACTTCCTTCCTGCTT	0.559													-	39923002	-	-	39922999	7	5	73	1	0	1	0	1	0	0	0	0	1386	565	20	0	1590	0	BCOR	23	39922999	Frame_Shift_Del	DEL	CTTC	TCGA-06-1804-01A-01D-1696-08	17810866	39922999	115347561	95	4948											
SLC9A7	84679	broad.mit.edu	37	chrX	46618211	46618211	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgaagagccagatggtgaggAtggtgagcgtgagcagcagg	19	5	0	6			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chrX:46618211A>T	uc004dgu.1	-	1	262	c.254T>A	c.(253-255)ATC>AAC	p.I85N	SLC9A7_uc004dgv.1_Missense_Mutation_p.I85N	NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	85	Helical; (Potential).				regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						GATGGTGAGGATGGTGAGCGT	0.632													T	46618211	T	T	46618211	3	4	73	1	0	0	0	0	1	0	0	0	14719	333	12	5	1991	5	SLC9A7	23	46618211	Missense_Mutation	SNP	A	TCGA-06-1804-01A-01D-1696-08	6695212	46618211	108652349	96	4949											
HUWE1	10075	broad.mit.edu	37	chrX	53600812	53600812	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctgccagaagacgaaggatAgtggaggtaggcattaaagg	15	5	1	2			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chrX:53600812A>G	uc004dsp.2	-	47	6612	c.6210T>C	c.(6208-6210)ACT>ACC	p.T2070T	HUWE1_uc004dsn.2_Silent_p.T894T	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2070					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GACGAAGGATAGTGGAGGTAG	0.502													G	53600812	G	G	53600812	2	3	73	1	0	0	0	0	0	0	0	1	7461	407	15	4		4	HUWE1	23	53600812	Silent	SNP	A	TCGA-06-1804-01A-01D-1696-08	6982601	53600812	101669748	97	4950											
POF1B	79983	broad.mit.edu	37	chrX	84634246	84634246	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagaggggagagcacttcccGtgagttgaaggggtccaagg	18	7	0	4			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chrX:84634246G>A	uc004eer.2	-	2	360	c.214C>T	c.(214-216)CGG>TGG	p.R72W	POF1B_uc004ees.2_Missense_Mutation_p.R72W	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	72							actin binding				0						AGCACTTCCCGTGAGTTGAAG	0.517													A	84634246	A	A	84634246	3	1	73	1	0	0	0	0	1	0	0	0	12182	1144	40	1	1619	1	POF1B	23	84634246	Missense_Mutation	SNP	G	TCGA-06-1804-01A-01D-1696-08	31033434	84634246	70636314	98	4951											
AGTR2	186	broad.mit.edu	37	chrX	115303791	115303791	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agcatatacatcttcaacctCgctgtggctgatttactcct	6	12	2	1	rs13306157		TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chrX:115303791C>T	uc004eqh.3	+	3	465	c.258C>T	c.(256-258)CTC>CTT	p.L86L		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	86	Helical; Name=2; (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						TCTTCAACCTCGCTGTGGCTG	0.378													T	115303791	T	T	115303791	2	4	73	1	0	0	0	0	0	0	0	1	402	871	31	2		2	AGTR2	23	115303791	Silent	SNP	C	TCGA-06-1804-01A-01D-1696-08	30669545	115303791	39966769	99	4952											
MAGEA5	4104	broad.mit.edu	37	chrX	151283685	151283685	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caagtcagccaccttcttacTgagtgctgctcggaacacag	9	13	2	1			TCGA-06-1804-01A-01D-1696-08	TCGA-06-1804-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d9a1ff46-8d28-451e-937f-bdad42bddd64	4302bb44-3440-4b71-8a4a-8d8b6acebcaa	g.chrX:151283685T>A	uc004ffj.2	-	3	533	c.328A>T	c.(328-330)AGT>TGT	p.S110C		NM_021049	NP_066387	P43359	MAGA5_HUMAN	melanoma antigen family A, 5	110	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					ACCTTCTTACTGAGTGCTGCT	0.488													A	151283685	A	A	151283685	3	1	73	1	0	0	0	0	1	0	0	0	9169	1580	55	5	50	5	MAGEA5	23	151283685	Missense_Mutation	SNP	T	TCGA-06-1804-01A-01D-1696-08	35979894	151283685	3986875	100	4953											
ARID1A	8289	broad.mit.edu	37	chr1	27106176	27106176	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accgaggatggagctaagagTtcagaggccatcaaggagag	15	7	2	3			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr1:27106176T>G	uc001bmv.1	+	20	6160	c.5787T>G	c.(5785-5787)AGT>AGG	p.S1929R	ARID1A_uc001bmu.1_Missense_Mutation_p.S1712R|ARID1A_uc001bmx.1_Missense_Mutation_p.S775R|ARID1A_uc009vsm.1_Missense_Mutation_p.S257R|ARID1A_uc009vsn.1_Missense_Mutation_p.S171R	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1929					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GAGCTAAGAGTTCAGAGGCCA	0.532			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								G	27106176	G	G	27106176	3	3	74	1	0	0	0	0	1	0	0	0	913	1722	60	5	5865	5	ARID1A	1	27106176	Missense_Mutation	SNP	T	TCGA-06-1806-01A-02D-1845-08		27106176	222144445	1	4954											
OR2L3	391192	broad.mit.edu	37	chr1	248224277	248224277	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tccttcactgggtgtgggatTcagagtttcttcttctcggc	11	10	5	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr1:248224277T>A	uc001idx.1	+	1	294	c.294T>A	c.(292-294)ATT>ATA	p.I98I	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GGTGTGGGATTCAGAGTTTCT	0.428													A	248224277	A	A	248224277	2	1	74	1	0	0	0	0	0	0	0	1	11008	1771	62	5		5	OR2L3	1	248224277	Silent	SNP	T	TCGA-06-1806-01A-02D-1845-08	221118101	248224277	1026344	2	4955											
ANTXR1	84168	broad.mit.edu	37	chr2	69240637	69240637	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgggctgcgggccatggcCacggcggagcggagagccct	18	15	0	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr2:69240637C>T	uc002sfg.2	+	1	362	c.6C>T	c.(4-6)GCC>GCT	p.A2A	ANTXR1_uc002sfe.2_Silent_p.A2A|ANTXR1_uc002sff.2_Silent_p.A2A|ANTXR1_uc002sfd.2_Silent_p.A2A	NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	2					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						GGGCCATGGCCACGGCGGAGC	0.721									Familial_Infantile_Hemangioma				T	69240637	T	T	69240637	2	4	74	1	0	0	0	0	0	0	0	1	711	581	21	3		3	ANTXR1	2	69240637	Silent	SNP	C	TCGA-06-1806-01A-02D-1845-08		69240637	173958736	3	4956											
IDUA	3425	broad.mit.edu	37	chr4	995272	995272	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaggtaggtacggactggcGcatgtttccaagtggaactt	14	8	0	0			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr4:995272G>A	uc003gby.2	+	5	598	c.510G>A	c.(508-510)GCG>GCA	p.A170A	IDUA_uc003gbz.2_RNA|IDUA_uc003gca.2_Silent_p.A123A	NM_000203	NP_000194	P35475	IDUA_HUMAN	alpha-L-iduronidase precursor	170					disaccharide metabolic process	lysosome	cation binding|L-iduronidase activity				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)		Laronidase(DB00090)	ACGGACTGGCGCATGTTTCCA	0.582													A	995272	A	A	995272	2	1	74	1	0	0	0	0	0	0	0	1	7504	1074	38	1		1	IDUA	4	995272	Silent	SNP	G	TCGA-06-1806-01A-02D-1845-08		995272	190159004	4	4957											
TMEM184C	55751	broad.mit.edu	37	chr4	148545074	148545074	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgggtgatattgcaacacttAgtgcattatacacaacctga	8	8	0	2			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr4:148545074A>G	uc003ila.3	+	2	782	c.213A>G	c.(211-213)TTA>TTG	p.L71L		NM_018241	NP_060711	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	71						integral to membrane					0						TGCAACACTTAGTGCATTATA	0.338													G	148545074	G	G	148545074	2	3	74	1	0	0	0	0	0	0	0	1	16103	417	15	4		4	TMEM184C	4	148545074	Silent	SNP	A	TCGA-06-1806-01A-02D-1845-08	147549802	148545074	42609202	5	4958											
MCC	4163	broad.mit.edu	37	chr5	112824054	112824054	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgctgctgccgctgccgcCgccgccgccgccgctgctgg	15	20	0	0			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr5:112824054C>T	uc003kql.3	-	1	474	c.58G>A	c.(58-60)GGC>AGC	p.G20S		NM_001085377	NP_001078846	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		ccgctgccgccgccgccgccg	0.408													T	112824054	T	T	112824054	3	4	74	1	0	0	0	0	1	0	0	0	9373	652	23	2	3138	2	MCC	5	112824054	Missense_Mutation	SNP	C	TCGA-06-1806-01A-02D-1845-08		112824054	68091206	6	4959											
PCDHB7	56129	broad.mit.edu	37	chr5	140554787	140554787	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcgcccatttcagaataatTtgggtttctgataaagaatg	8	6	2	3			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr5:140554787T>G	uc003lit.2	+	1	2545	c.2371T>G	c.(2371-2373)TTG>GTG	p.L791V	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	791	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAGAATAATTTGGGTTTCTG	0.423													G	140554787	G	G	140554787	3	3	74	1	0	0	0	0	1	0	0	0	11547	1838	64	5	2373	5	PCDHB7	5	140554787	Missense_Mutation	SNP	T	TCGA-06-1806-01A-02D-1845-08	27730733	140554787	40360473	7	4960											
F13A1	2162	broad.mit.edu	37	chr6	6145963	6145963	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcccagagacccagggccgGcacacttcttcccactgcac	9	18	1	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr6:6145963G>A	uc003mwv.2	-	15	2211	c.2088C>T	c.(2086-2088)TGC>TGT	p.C696C	F13A1_uc011dib.1_Missense_Mutation_p.A590V	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	696					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CCCAGGGCCGGCACACTTCTT	0.547													A	6145963	A	A	6145963	2	1	74	1	0	0	0	0	0	0	0	1	5340	1195	42	3		3	F13A1	6	6145963	Silent	SNP	G	TCGA-06-1806-01A-02D-1845-08		6145963	164969104	8	4961											
IQCE	23288	broad.mit.edu	37	chr7	2644610	2644610	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcagagccacccagcgtgccAggcctcccagaccaggtaat	10	16	1	2			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr7:2644610A>G	uc003smo.3	+	19	1912	c.1728A>G	c.(1726-1728)CCA>CCG	p.P576P	IQCE_uc003sml.1_Silent_p.P576P|IQCE_uc011jvy.1_Silent_p.P560P|IQCE_uc011jvz.1_Silent_p.P511P|IQCE_uc003smk.3_Silent_p.P560P|IQCE_uc003smn.3_Silent_p.P511P	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	576											0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		CCAGCGTGCCAGGCCTCCCAG	0.612													G	2644610	G	G	2644610	2	3	74	1	0	0	0	0	0	0	0	1	7806	175	7	4		4	IQCE	7	2644610	Silent	SNP	A	TCGA-06-1806-01A-02D-1845-08		2644610	156494053	9	4962											
CACNA2D1	781	broad.mit.edu	37	chr7	81591237	81591238	+	Missense_Mutation	DNP	CC	AT	AT													agtttccacagtctaatacaCcactgaatgatttactgtcg							TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr7:81591237_81591238CC>AT	uc003uhr.1	-	36	3194_3195	c.2938_2939GG>AT	c.(2938-2940)GGT>ATT	p.G980I	CACNA2D1_uc011kgy.1_Missense_Mutation_p.G192I	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	992	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GTCTAATACACCACTGAATGAT	0.361													AT	81591238	AT	AT	81591237	3	1	74	1	0	0	0	0	1	0	0	0	2548	507	18	5	352	5	CACNA2D1	7	81591237	Missense_Mutation	DNP	CC	TCGA-06-1806-01A-02D-1845-08	78946627	81591237	77547426	10	4963											
NAMPT	10135	broad.mit.edu	37	chr7	105909693	105909693	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctaacaaatatttggccaaTattttcttctgctctctaga	4	9	4	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr7:105909693T>C	uc003vdq.2	-	5	821	c.513A>G	c.(511-513)ATA>ATG	p.I171M	NAMPT_uc003vdr.1_Missense_Mutation_p.I171M|NAMPT_uc011klu.1_Missense_Mutation_p.I84M	NM_005746	NP_005737	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	171					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			large_intestine(1)	1						ATTTGGCCAATATTTTCTTCT	0.363													C	105909693	C	C	105909693	3	2	74	1	0	0	0	0	1	0	0	0	10149	1396	49	4	990	4	NAMPT	7	105909693	Missense_Mutation	SNP	T	TCGA-06-1806-01A-02D-1845-08	24318456	105909693	53228970	11	4964											
BRAF	673	broad.mit.edu	37	chr7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acccactccatcgagatttcActgtagctagaccaaaatca	5	13	2	2			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				T	140453136	T	T	140453136	3	4	74	1	0	0	0	0	1	0	0	0	1496	159	6	5	517	5	BRAF	7	140453136	Missense_Mutation	SNP	A	TCGA-06-1806-01A-02D-1845-08	34543443	140453136	18685527	12	4965											
SLCO5A1	81796	broad.mit.edu	37	chr8	70585394	70585394	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggagtaccaggccagaaaaaTaaaaataaacccaacgaatt	7	8	0	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr8:70585394T>C	uc003xyl.2	-	10	2964	c.2257A>G	c.(2257-2259)ATT>GTT	p.I753V	SLCO5A1_uc010lzb.2_Missense_Mutation_p.I698V|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	753	Helical; Name=12; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GCCAGAAAAATAAAAATAAAC	0.488													C	70585394	C	C	70585394	3	2	74	1	0	0	0	0	1	0	0	0	14731	1406	49	4	293	4	SLCO5A1	8	70585394	Missense_Mutation	SNP	T	TCGA-06-1806-01A-02D-1845-08		70585394	75778628	13	4966											
QSOX2	169714	broad.mit.edu	37	chr9	139108556	139108556	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcttcttgactggcggccGtccagggaacagctgcatga	13	12	1	2			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr9:139108556G>A	uc010nbi.2	-	9	1137	c.1099C>T	c.(1099-1101)CGG>TGG	p.R367W		NM_181701	NP_859052	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2 precursor	367					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		ACTGGCGGCCGTCCAGGGAAC	0.642													A	139108556	A	A	139108556	3	1	74	1	0	0	0	0	1	0	0	0	12884	1144	40	1	1013	1	QSOX2	9	139108556	Missense_Mutation	SNP	G	TCGA-06-1806-01A-02D-1845-08		139108556	2104875	14	4967											
SYT13	57586	broad.mit.edu	37	chr11	45273992	45273992	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttcgctgaagtcttcagctCgccccactgggcagccccta	9	17	2	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr11:45273992C>T	uc001myq.2	-	4	952	c.826G>A	c.(826-828)GAG>AAG	p.E276K	SYT13_uc009yku.1_Missense_Mutation_p.E132K	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	276	Cytoplasmic (Potential).					transport vesicle				ovary(1)	1						GTCTTCAGCTCGCCCCACTGG	0.632											OREG0020928	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	45273992	T	T	45273992	3	4	74	1	0	0	0	0	1	0	0	0	15466	893	31	2	466	2	SYT13	11	45273992	Missense_Mutation	SNP	C	TCGA-06-1806-01A-02D-1845-08		45273992	89732524	15	4968											
MAPK8IP1	9479	broad.mit.edu	37	chr11	45927211	45927211	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggcttctaggagagcattccAgcagttctacaagcagtttg	11	9	2	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr11:45927211A>G	uc001nbr.2	+	12	2245	c.2075A>G	c.(2074-2076)CAG>CGG	p.Q692R		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	692	PID.				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		AGAGCATTCCAGCAGTTCTAC	0.597													G	45927211	G	G	45927211	3	3	74	1	0	0	0	0	1	0	0	0	9284	188	7	4	2121	4	MAPK8IP1	11	45927211	Missense_Mutation	SNP	A	TCGA-06-1806-01A-02D-1845-08	653219	45927211	89079305	16	4969											
PTPRJ	5795	broad.mit.edu	37	chr11	48185118	48185118	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcaacttccggtacctcgttCgtgactacatgaagcagagt	9	11	1	3			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr11:48185118C>T	uc001ngp.3	+	23	4022	c.3667C>T	c.(3667-3669)CGT>TGT	p.R1223C		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1223	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						GTACCTCGTTCGTGACTACAT	0.517													T	48185118	T	T	48185118	3	4	74	1	0	0	0	0	1	0	0	0	12804	884	31	2	3766	2	PTPRJ	11	48185118	Missense_Mutation	SNP	C	TCGA-06-1806-01A-02D-1845-08	2257907	48185118	86821398	17	4970											
ZNF202	7753	broad.mit.edu	37	chr11	123597645	123597645	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaacaggcctgtgtatatccTccaaactcagatcttcctgc	6	13	2	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr11:123597645T>C	uc001pzd.1	-	9	1407	c.1007A>G	c.(1006-1008)GAG>GGG	p.E336G	ZNF202_uc001pzc.1_Missense_Mutation_p.E112G|ZNF202_uc001pze.1_Missense_Mutation_p.E336G|ZNF202_uc001pzf.1_Missense_Mutation_p.E336G	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	336					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		GTGTATATCCTCCAAACTCAG	0.453													C	123597645	C	C	123597645	3	2	74	1	0	0	0	0	1	0	0	0	17760	1551	54	4	943	4	ZNF202	11	123597645	Missense_Mutation	SNP	T	TCGA-06-1806-01A-02D-1845-08	75412527	123597645	11408871	18	4971											
B3GAT1	27087	broad.mit.edu	37	chr11	134253884	134253884	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcagcgtgttggccatgCgcgtcagctcggccttctgc	14	14	2	0			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr11:134253884C>T	uc001qhq.2	-	4	572	c.311G>A	c.(310-312)CGC>CAC	p.R104H	B3GAT1_uc001qhr.2_Missense_Mutation_p.R104H|B3GAT1_uc010scv.1_Missense_Mutation_p.R117H	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	104	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		GTTGGCCATGCGCGTCAGCTC	0.716													T	134253884	T	T	134253884	3	4	74	1	0	0	0	0	1	0	0	0	1253	768	27	1	705	1	B3GAT1	11	134253884	Missense_Mutation	SNP	C	TCGA-06-1806-01A-02D-1845-08	10656239	134253884	752632	19	4972											
PDZRN4	29951	broad.mit.edu	37	chr12	41967365	41967365	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggagtggcatgaccacagaCgatgacaccatgagcgagat	13	10	0	5			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr12:41967365C>T	uc010skn.1	+	10	2255	c.2187C>T	c.(2185-2187)GAC>GAT	p.D729D	PDZRN4_uc001rmq.3_Silent_p.D670D|PDZRN4_uc009zjz.2_Silent_p.D668D|PDZRN4_uc001rmr.2_Silent_p.D555D	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	928							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TGACCACAGACGATGACACCA	0.562													T	41967365	T	T	41967365	2	4	74	1	0	0	0	0	0	0	0	1	11710	535	19	1		1	PDZRN4	12	41967365	Silent	SNP	C	TCGA-06-1806-01A-02D-1845-08		41967365	91884530	20	4973											
LRRIQ1	84125	broad.mit.edu	37	chr12	85459127	85459127	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcagtttctatcccttcgaCgctgtggattaacttctttg	7	10	3	0			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr12:85459127C>T	uc001tac.2	+	9	2590	c.2479C>T	c.(2479-2481)CGC>TGC	p.R827C	LRRIQ1_uc001tab.1_Missense_Mutation_p.R827C	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	827	LRR 1.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ATCCCTTCGACGCTGTGGATT	0.393													T	85459127	T	T	85459127	3	4	74	1	0	0	0	0	1	0	0	0	9029	536	19	1	2509	1	LRRIQ1	12	85459127	Missense_Mutation	SNP	C	TCGA-06-1806-01A-02D-1845-08	43491762	85459127	48392768	21	4974											
LUM	4060	broad.mit.edu	37	chr12	91502172	91502172	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ccagaaggcagtctggctatCtgattgaagctcaagtcaag	11	9	4	3			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr12:91502172C>G	uc001tbm.2	-	2	974	c.585G>C	c.(583-585)CAG>CAC	p.Q195H	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	195	LRR 6.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						GTCTGGCTATCTGATTGAAGC	0.428													G	91502172	G	G	91502172	3	3	74	1	0	0	0	0	1	0	0	0	9085	912	32	5	439	5	LUM	12	91502172	Missense_Mutation	SNP	C	TCGA-06-1806-01A-02D-1845-08	6043045	91502172	42349723	22	4975											
AKAP13	11214	broad.mit.edu	37	chr15	86286791	86286791	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtcctgaggagcccccctcGccatctgcaccttccatagc	8	18	1	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr15:86286791G>A	uc002blv.1	+	36	8297	c.8127G>A	c.(8125-8127)TCG>TCA	p.S2709S	AKAP13_uc002blu.1_Silent_p.S2713S|AKAP13_uc002blw.1_Silent_p.S1174S|AKAP13_uc002blx.1_Silent_p.S954S	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2709	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AGCCCCCCTCGCCATCTGCAC	0.502													A	86286791	A	A	86286791	2	1	74	1	0	0	0	0	0	0	0	1	449	1074	38	1		1	AKAP13	15	86286791	Silent	SNP	G	TCGA-06-1806-01A-02D-1845-08		86286791	16244601	23	4976											
MLST8	64223	broad.mit.edu	37	chr16	2256651	2256651	+	Frame_Shift_Del	DEL	G	-	-													ggactgcacagccaggatctGggacctcaggtgcggtgggg							TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr16:2256651delG	uc002coz.2	+	4	454	c.335delG	c.(334-336)TGGfs	p.W112fs	MLST8_uc002coy.2_Frame_Shift_Del_p.W112fs|MLST8_uc002cpa.2_5'UTR|MLST8_uc002cpb.2_Frame_Shift_Del_p.W111fs|MLST8_uc010uvx.1_Frame_Shift_Del_p.W46fs|MLST8_uc002cpc.2_Frame_Shift_Del_p.W112fs|MLST8_uc002cpd.2_Frame_Shift_Del_p.W46fs|MLST8_uc002cpe.2_Frame_Shift_Del_p.W112fs|MLST8_uc010uvy.1_Frame_Shift_Del_p.W112fs|MLST8_uc002cpg.2_Frame_Shift_Del_p.W131fs|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_Frame_Shift_Del_p.W112fs	NM_022372	NP_071767	Q9BVC4	LST8_HUMAN	G protein beta subunit-like	112	WD 3.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0						GCCAGGATCTGGGACCTCAGG	0.557													-	2256651	-	-	2256651	7	5	74	1	0	1	0	1	0	0	0	0	9634	1357	47	0	345	0	MLST8	16	2256651	Frame_Shift_Del	DEL	G	TCGA-06-1806-01A-02D-1845-08		2256651	88098102	24	4977											
ATP9B	374868	broad.mit.edu	37	chr18	77133909	77133909	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtttttcaggcggcatcctcAtgtatggggccctggtgctc	13	11	2	0			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr18:77133909A>T	uc002lmx.2	+	28	3096	c.3082A>T	c.(3082-3084)ATG>TTG	p.M1028L	ATP9B_uc002lmw.1_Missense_Mutation_p.M1028L|ATP9B_uc002lna.2_Missense_Mutation_p.M54L|ATP9B_uc002lnb.1_Missense_Mutation_p.H126L|ATP9B_uc010drb.2_RNA	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	1028	Helical; (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		CGGCATCCTCATGTATGGGGC	0.567													T	77133909	T	T	77133909	3	4	74	1	0	0	0	0	1	0	0	0	1199	217	8	5	3192	5	ATP9B	18	77133909	Missense_Mutation	SNP	A	TCGA-06-1806-01A-02D-1845-08		77133909	943339	25	4978											
DOT1L	84444	broad.mit.edu	37	chr19	2216705	2216705	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaagattgtgctgaggcgGcacctgagccaggaccacac	13	13	0	3			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr19:2216705G>A	uc002lvb.3	+	20	2385	c.2349G>A	c.(2347-2349)CGG>CGA	p.R783R	DOT1L_uc002lvc.1_Silent_p.R77R|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_Silent_p.R77R	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	783						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCTGAGGCGGCACCTGAGCC	0.687													A	2216705	A	A	2216705	2	1	74	1	0	0	0	0	0	0	0	1	4709	1190	42	3		3	DOT1L	19	2216705	Silent	SNP	G	TCGA-06-1806-01A-02D-1845-08		2216705	56912278	26	4979											
FUT5	2527	broad.mit.edu	37	chr19	5867010	5867010	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctccatcatggtccccttggGcaggggcttgtgggagcgtc	15	12	1	0			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr19:5867010G>C	uc002mdo.3	-	2	815	c.727C>G	c.(727-729)CCC>GCC	p.P243A	FUT5_uc010duo.2_Missense_Mutation_p.P243A	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	243	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						GTCCCCTTGGGCAGGGGCTTG	0.602													C	5867010	C	C	5867010	3	2	74	1	0	0	0	0	1	0	0	0	6107	1203	42	5	401	5	FUT5	19	5867010	Missense_Mutation	SNP	G	TCGA-06-1806-01A-02D-1845-08	3650305	5867010	53261973	27	4980											
NOSIP	51070	broad.mit.edu	37	chr19	50059597	50059597	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagcacgatgatgtcgcGgtctgtgagtttgtctccag	13	10	2	2			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr19:50059597G>A	uc002pok.2	-	9	963	c.811C>T	c.(811-813)CGC>TGC	p.R271C	NOSIP_uc002pol.2_Missense_Mutation_p.R271C	NM_015953	NP_057037	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	271					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		ATGATGTCGCGGTCTGTGAGT	0.383													A	50059597	A	A	50059597	3	1	74	1	0	0	0	0	1	0	0	0	10545	1116	39	2	102	2	NOSIP	19	50059597	Missense_Mutation	SNP	G	TCGA-06-1806-01A-02D-1845-08	44192587	50059597	9069386	28	4981											
ADAM33	80332	broad.mit.edu	37	chr20	3652076	3652076	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggctctcaccccgtggctgTggcaggcagtcaggcagcgc	16	14	2	0			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr20:3652076T>C	uc002wit.2	-	17	2060	c.1973A>G	c.(1972-1974)CAC>CGC	p.H658R	ADAM33_uc002wiq.1_5'Flank|ADAM33_uc002wir.1_Missense_Mutation_p.H658R|ADAM33_uc002wis.2_Intron|ADAM33_uc002wiu.2_Intron|uc002wiv.1_5'Flank|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	658	Extracellular (Potential).|EGF-like.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						CCCGTGGCTGTGGCAGGCAGT	0.612													C	3652076	C	C	3652076	3	2	74	1	0	0	0	0	1	0	0	0	250	1696	59	4	492	4	ADAM33	20	3652076	Missense_Mutation	SNP	T	TCGA-06-1806-01A-02D-1845-08		3652076	59373444	29	4982											
CSRP2BP	57325	broad.mit.edu	37	chr20	18165284	18165284	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtctgcagtacccagacttcAgtgttgttgttctttataaa	8	8	3	1			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr20:18165284A>C	uc002wqj.2	+	10	2645	c.2023A>C	c.(2023-2025)AGT>CGT	p.S675R	CSRP2BP_uc002wqk.2_Missense_Mutation_p.S547R|CSRP2BP_uc010zru.1_Missense_Mutation_p.S546R	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	675	N-acetyltransferase.				histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						CCCAGACTTCAGTGTTGTTGT	0.408													C	18165284	C	C	18165284	3	2	74	1	0	0	0	0	1	0	0	0	3968	188	7	5	2057	5	CSRP2BP	20	18165284	Missense_Mutation	SNP	A	TCGA-06-1806-01A-02D-1845-08	14513208	18165284	44860236	30	4983											
SEMG2	6407	broad.mit.edu	37	chr20	43851863	43851863	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaaggaaagtctggtcaatcTgcagatagcaaacaagacct	9	8	3	2			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr20:43851863T>A	uc010ggz.2	+	2	1647	c.1590T>A	c.(1588-1590)TCT>TCA	p.S530S	SEMG2_uc002xnk.2_Silent_p.S530S|SEMG2_uc002xnl.2_Silent_p.S410S	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	530	Repeat-rich region.|3-2.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CTGGTCAATCTGCAGATAGCA	0.388													A	43851863	A	A	43851863	2	1	74	1	0	0	0	0	0	0	0	1	14045	1567	55	5		5	SEMG2	20	43851863	Silent	SNP	T	TCGA-06-1806-01A-02D-1845-08	25686579	43851863	19173657	31	4984											
ARFGAP1	55738	broad.mit.edu	37	chr20	61910293	61910293	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtttgggaacacgccaccGcctcagaagaaagaagatga	13	9	1	5	rs143521520	byFrequency	TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr20:61910293G>A	uc002yem.2	+	7	685	c.573G>A	c.(571-573)CCG>CCA	p.P191P	ARFGAP1_uc011aas.1_Silent_p.P138P|ARFGAP1_uc011aat.1_Silent_p.P78P|ARFGAP1_uc002yel.2_Silent_p.P191P|ARFGAP1_uc002yen.2_Silent_p.P191P	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	191					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					ACACGCCACCGCCTCAGAAGA	0.597													A	61910293	A	A	61910293	2	1	74	1	0	0	0	0	0	0	0	1	849	1074	38	1		1	ARFGAP1	20	61910293	Silent	SNP	G	TCGA-06-1806-01A-02D-1845-08	18058430	61910293	1115227	32	4985											
IFNGR2	3460	broad.mit.edu	37	chr21	34809223	34809223	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgggactctgtgtccattaTctcgtttccggaaaaggagc	11	10	2	0			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr21:34809223T>C	uc002yrp.3	+	7	1616	c.968T>C	c.(967-969)ATC>ACC	p.I323T	IFNGR2_uc002yrq.3_Missense_Mutation_p.I342T|IFNGR2_uc010gma.2_Missense_Mutation_p.I244T|IFNGR2_uc002yrr.3_Missense_Mutation_p.I244T|TMEM50B_uc002yrs.1_Intron	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	323	Cytoplasmic (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	GTGTCCATTATCTCGTTTCCG	0.502													C	34809223	C	C	34809223	3	2	74	1	0	0	0	0	1	0	0	0	7550	1435	50	4	994	4	IFNGR2	21	34809223	Missense_Mutation	SNP	T	TCGA-06-1806-01A-02D-1845-08		34809223	13320672	33	4986											
SRRD	402055	broad.mit.edu	37	chr22	26887547	26887547	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaacagctctccatagataTttgggagtttcgggaagaac	11	7	1	3			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chr22:26887547T>C	uc010gve.2	+	7	936	c.929T>C	c.(928-930)ATT>ACT	p.I310T	SRRD_uc003acp.3_Missense_Mutation_p.I303T|uc003acu.1_5'Flank	NM_001013694	NP_001013716	Q9UH36	SRR1L_HUMAN	SRR1 domain containing	310					rhythmic process						0						TCCATAGATATTTGGGAGTTT	0.433													C	26887547	C	C	26887547	3	2	74	1	0	0	0	0	1	0	0	0	15166	1493	52	4	955	4	SRRD	22	26887547	Missense_Mutation	SNP	T	TCGA-06-1806-01A-02D-1845-08		26887547	24417019	34	4987											
NHS	4810	broad.mit.edu	37	chrX	17745854	17745854	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagactcttctgcagttgagAtgggaccagataaactacat	9	8	2	3			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chrX:17745854A>G	uc004cxx.2	+	6	3903	c.3565A>G	c.(3565-3567)ATG>GTG	p.M1189V	NHS_uc011mix.1_Missense_Mutation_p.M1210V|NHS_uc004cxy.2_Missense_Mutation_p.M1033V|NHS_uc004cxz.2_Missense_Mutation_p.M1012V|NHS_uc004cya.2_Missense_Mutation_p.M912V	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1189						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					TGCAGTTGAGATGGGACCAGA	0.398													G	17745854	G	G	17745854	3	3	74	1	0	0	0	0	1	0	0	0	10411	333	12	4	3692	4	NHS	23	17745854	Missense_Mutation	SNP	A	TCGA-06-1806-01A-02D-1845-08		17745854	137524706	35	4988											
PGAM4	441531	broad.mit.edu	37	chrX	77224407	77224407	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccctgggcagccacagcttcTatggctttgcacaccgtctc	9	16	2	0			TCGA-06-1806-01A-02D-1845-08	TCGA-06-1806-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	beb40d7c-3861-4efe-9b1d-34ba68a66c9d	0cb9ab6d-0c9e-459b-af28-7f2e3b870ca5	g.chrX:77224407T>C	uc004ecy.1	-	1	729	c.729A>G	c.(727-729)ATA>ATG	p.I243M	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	243					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						CCACAGCTTCTATGGCTTTGC	0.567													C	77224407	C	C	77224407	3	2	74	1	0	0	0	0	1	0	0	0	11775	1512	53	4	39	4	PGAM4	23	77224407	Missense_Mutation	SNP	T	TCGA-06-1806-01A-02D-1845-08	59478553	77224407	78046153	36	4989											
ATP13A2	23400	broad.mit.edu	37	chr1	17314833	17314833	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttacctgatgaccatgggcaCgcactcaatactggccatgc	9	13	1	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr1:17314833C>T	uc001baa.2	-	24	2936	c.2746G>A	c.(2746-2748)GTG>ATG	p.V916M	ATP13A2_uc001azz.1_Missense_Mutation_p.V63M|ATP13A2_uc001bab.2_Missense_Mutation_p.V911M|ATP13A2_uc001bac.2_Missense_Mutation_p.V872M	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	916	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		ACCATGGGCACGCACTCAATA	0.642													T	17314833	T	T	17314833	3	4	75	1	0	0	0	0	1	0	0	0	1124	536	19	1	1056	1	ATP13A2	1	17314833	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08		17314833	231935788	1	4990											
CNKSR1	10256	broad.mit.edu	37	chr1	26507077	26507077	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccaggagctcatcctgggCggggtggaacagctccaggc	15	13	1	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr1:26507077C>T	uc001bln.3	+	2	244	c.186C>T	c.(184-186)GGC>GGT	p.G62G	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Silent_p.G62G|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	62	SAM.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TCATCCTGGGCGGGGTGGAAC	0.657													T	26507077	T	T	26507077	2	4	75	1	0	0	0	0	0	0	0	1	3606	755	27	1		1	CNKSR1	1	26507077	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	9192244	26507077	222743544	2	4991											
GJB4	127534	broad.mit.edu	37	chr1	35227182	35227182	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcaagcaccacctgaaacaCgggcccaatgccccgtccct	8	19	0	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr1:35227182C>T	uc001bxv.1	+	2	697	c.327C>T	c.(325-327)CAC>CAT	p.H109H	GJB4_uc001bxw.3_Silent_p.H109H	NM_153212	NP_694944	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4	109	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				ACCTGAAACACGGGCCCAATG	0.632													T	35227182	T	T	35227182	2	4	75	1	0	0	0	0	0	0	0	1	6410	535	19	1		1	GJB4	1	35227182	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	8720105	35227182	214023439	3	4992											
MYSM1	114803	broad.mit.edu	37	chr1	59132729	59132729	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctggtatttagcttgtgtgTcaatatctcgtaaggaagga	11	6	2	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr1:59132729T>C	uc009wab.1	-	16	2035	c.2012A>G	c.(2011-2013)GAC>GGC	p.D671G	MYSM1_uc009waa.1_Missense_Mutation_p.D77G|MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	671	MPN.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					AGCTTGTGTGTCAATATCTCG	0.373													C	59132729	C	C	59132729	3	2	75	1	0	0	0	0	1	0	0	0	10101	1667	58	4	494	4	MYSM1	1	59132729	Missense_Mutation	SNP	T	TCGA-06-2557-01A-01D-1494-08	23905547	59132729	190117892	4	4993											
LRRC7	57554	broad.mit.edu	37	chr1	70505050	70505050	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcccccaactgataggtaCggcagacccccatatagggg	11	14	0	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr1:70505050C>T	uc001dep.2	+	19	3459	c.3429C>T	c.(3427-3429)TAC>TAT	p.Y1143Y	LRRC7_uc009wbg.2_Silent_p.Y427Y|LRRC7_uc001deq.2_Silent_p.Y384Y	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1143						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CTGATAGGTACGGCAGACCCC	0.557													T	70505050	T	T	70505050	2	4	75	1	0	0	0	0	0	0	0	1	9020	547	19	1		1	LRRC7	1	70505050	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	11372321	70505050	178745571	5	4994											
TTF2	8458	broad.mit.edu	37	chr1	117603105	117603105	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgctttcttaagaccggcgtCcgcgatggcccgaataaagg	12	11	1	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr1:117603105C>T	uc001egy.2	+	2	77	c.57C>T	c.(55-57)GTC>GTT	p.V19V	TTF2_uc001egx.1_Silent_p.V19V	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	19					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		AGACCGGCGTCCGCGATGGCC	0.582													T	117603105	T	T	117603105	2	4	75	1	0	0	0	0	0	0	0	1	16716	842	30	3		3	TTF2	1	117603105	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	47098055	117603105	131647516	6	4995											
AQP10	89872	broad.mit.edu	37	chr1	154294516	154294516	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgttacgatagccatctaCgtgggtggtaacgtctcagg	13	10	2	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr1:154294516C>T	uc001feu.2	+	2	253	c.213C>T	c.(211-213)TAC>TAT	p.Y71Y	AQP10_uc001fev.2_Silent_p.Y71Y	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	71	Helical; (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TAGCCATCTACGTGGGTGGTA	0.557													T	154294516	T	T	154294516	2	4	75	1	0	0	0	0	0	0	0	1	822	547	19	1		1	AQP10	1	154294516	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	36691411	154294516	94956105	7	4996											
PIK3C2B	5287	broad.mit.edu	37	chr1	204410639	204410639	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctcacccaggggatccacaTtttggaaggagagtttgagg	13	8	1	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr1:204410639T>G	uc001haw.2	-	22	3688	c.3209A>C	c.(3208-3210)AAT>ACT	p.N1070T	PIK3C2B_uc010pqv.1_Missense_Mutation_p.N1042T	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1070					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GGGATCCACATTTTGGAAGGA	0.527													G	204410639	G	G	204410639	3	3	75	1	0	0	0	0	1	0	0	0	11910	1493	52	5	1747	5	PIK3C2B	1	204410639	Missense_Mutation	SNP	T	TCGA-06-2557-01A-01D-1494-08	50116123	204410639	44839982	8	4997											
CHRM3	1131	broad.mit.edu	37	chr1	240071079	240071079	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaactacttcctcttaagcCtggcctgtgccgatctgatt	7	13	2	1	rs111407169	byFrequency	TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr1:240071079C>T	uc001hyp.2	+	5	1107	c.328C>T	c.(328-330)CTG>TTG	p.L110L		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	110	Helical; Name=2; (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CCTCTTAAGCCTGGCCTGTGC	0.478													T	240071079	T	T	240071079	2	4	75	1	0	0	0	0	0	0	0	1	3378	680	24	3		3	CHRM3	1	240071079	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	35660440	240071079	9179542	9	4998											
FAM136A	84908	broad.mit.edu	37	chr2	70524463	70524463	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gcctccttcatcttcttggtCatagttgggatgaggtgcat	11	9	4	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr2:70524463C>T	uc002sgq.3	-	3	452	c.375G>A	c.(373-375)ATG>ATA	p.M125I	FAM136A_uc010fdp.2_RNA	NM_032822	NP_116211	Q96C01	F136A_HUMAN	hypothetical protein LOC84908	125						mitochondrion	protein binding				0						TCTTCTTGGTCATAGTTGGGA	0.433													T	70524463	T	T	70524463	3	4	75	1	0	0	0	0	1	0	0	0	5450	826	29	3	45	3	FAM136A	2	70524463	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08		70524463	172674910	10	4999											
NAT8B	51471	broad.mit.edu	37	chr2	73928290	73928290	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagtagggcaagggcccccCcaagtaagagtatgagggtt	16	8	0	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr2:73928290C>T	uc002sjk.1	-	2	178	c.143G>A	c.(142-144)GGG>GAG	p.G48E		NM_016347	NP_057431	Q9UHF3	NAT8B_HUMAN	N-acetyltransferase 8B	48	Helical; (Potential).				gastrulation with mouth forming second	integral to membrane	N-acetyltransferase activity				0						AAGGGCCCCCCCAAGTAAGAG	0.612													T	73928290	T	T	73928290	3	4	75	1	0	0	0	0	1	0	0	0	10180	623	22	3	544	3	NAT8B	2	73928290	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	3403827	73928290	169271083	11	5000											
CCDC138	165055	broad.mit.edu	37	chr2	109410997	109410997	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatgttattttctttgcagtTgccttgccaactaatacgac	6	9	1	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr2:109410997T>C	uc002ten.1	+	5	456	c.396T>C	c.(394-396)GTT>GTC	p.V132V	CCDC138_uc002teo.1_Silent_p.V132V|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	132											0						TCTTTGCAGTTGCCTTGCCAA	0.363													C	109410997	C	C	109410997	2	2	75	1	0	0	0	0	0	0	0	1	2772	1826	63	4		4	CCDC138	2	109410997	Silent	SNP	T	TCGA-06-2557-01A-01D-1494-08	35482707	109410997	133788376	12	5001											
POTEF	728378	broad.mit.edu	37	chr2	130877735	130877735	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatcgtagtctccccaagcGcccaccttgctcttgctgct	7	17	3	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr2:130877735G>A	uc010fmh.2	-	3	754	c.354C>T	c.(352-354)GGC>GGT	p.G118G		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	118						cell cortex	ATP binding			skin(3)|ovary(2)	5						CTCCCCAAGCGCCCACCTTGC	0.587													A	130877735	A	A	130877735	2	1	75	1	0	0	0	0	0	0	0	1	12265	1074	38	1		1	POTEF	2	130877735	Silent	SNP	G	TCGA-06-2557-01A-01D-1494-08	21466738	130877735	112321638	13	5002											
LRP1B	53353	broad.mit.edu	37	chr2	141986959	141986959	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tccattaagatagaaaacctCaattgtttcaaaatttgcaa	4	7	2	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr2:141986959C>A	uc002tvj.1	-	6	1615	c.643G>T	c.(643-645)GAG>TAG	p.E215*	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	215	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAGAAAACCTCAATTGTTTCA	0.284										TSP Lung(27;0.18)			A	141986959	A	A	141986959	4	1	75	1	0	0	0	0	0	1	0	0	8955	835	29	5	13500	5	LRP1B	2	141986959	Nonsense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	11109224	141986959	101212414	14	5003											
PLCL1	5334	broad.mit.edu	37	chr2	198949321	198949321	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttagacatcataaggagataCgaactttctgaagagggacg	11	6	2	4			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr2:198949321C>T	uc010fsp.2	+	2	1371	c.1080C>T	c.(1078-1080)TAC>TAT	p.Y360Y	PLCL1_uc002uuv.3_Silent_p.Y281Y	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	360					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TAAGGAGATACGAACTTTCTG	0.388													T	198949321	T	T	198949321	2	4	75	1	0	0	0	0	0	0	0	1	12039	547	19	1		1	PLCL1	2	198949321	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	56962362	198949321	44250052	15	5004											
SCN5A	6331	broad.mit.edu	37	chr3	38622444	38622444	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttgctggactcctcctccGtgcccaggctgttctcctca	9	17	2	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr3:38622444G>A	uc003cio.2	-	17	3400	c.3206C>T	c.(3205-3207)ACG>ATG	p.T1069M	SCN5A_uc003cin.2_Missense_Mutation_p.T1069M|SCN5A_uc003cil.3_Missense_Mutation_p.T1069M|SCN5A_uc010hhi.2_Missense_Mutation_p.T1069M|SCN5A_uc010hhk.2_Missense_Mutation_p.T1069M|SCN5A_uc011ayr.1_Missense_Mutation_p.T1069M|SCN5A_uc010hhj.1_Missense_Mutation_p.T680M	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1069					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CTCCTCCTCCGTGCCCAGGCT	0.627													A	38622444	A	A	38622444	3	1	75	1	0	0	0	0	1	0	0	0	13922	1145	40	1	2892	1	SCN5A	3	38622444	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08		38622444	159399986	16	5005											
ABI3BP	25890	broad.mit.edu	37	chr3	100645260	100645260	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttacatttggacttggacGcaagaacttcaagaggatgg	11	7	1	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr3:100645260G>A	uc003dun.2	-	2	251	c.166C>T	c.(166-168)CGT>TGT	p.R56C	ABI3BP_uc003duo.2_Missense_Mutation_p.R49C|ABI3BP_uc003dup.3_Missense_Mutation_p.R49C	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	56						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						GGACTTGGACGCAAGAACTTC	0.448													A	100645260	A	A	100645260	3	1	75	1	0	0	0	0	1	0	0	0	91	1087	38	1	3197	1	ABI3BP	3	100645260	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08	62022816	100645260	97377170	17	5006											
ZPLD1	131368	broad.mit.edu	37	chr3	102157373	102157373	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcttctaacaattagagtGcttccggggtctgctcagtt	10	10	3	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr3:102157373G>A	uc003dvs.1	+	9	924	c.42G>A	c.(40-42)GTG>GTA	p.V14V	ZPLD1_uc003dvt.1_Silent_p.V30V|ZPLD1_uc011bhg.1_Silent_p.V14V	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	14						integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						CAATTAGAGTGCTTCCGGGGT	0.433													A	102157373	A	A	102157373	2	1	75	1	0	0	0	0	0	0	0	1	18218	1306	46	3		3	ZPLD1	3	102157373	Silent	SNP	G	TCGA-06-2557-01A-01D-1494-08	1512113	102157373	95865057	18	5007											
CCDC37	348807	broad.mit.edu	37	chr3	126153142	126153142	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tcattgagcaccagctggatGagctgctagagaacctggag	13	9	1	3			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr3:126153142G>A	uc003eiu.1	+	15	1645	c.1546G>A	c.(1546-1548)GAG>AAG	p.E516K	CCDC37_uc010hsg.1_Missense_Mutation_p.E517K	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	516										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		CCAGCTGGATGAGCTGCTAGA	0.622													A	126153142	A	A	126153142	3	1	75	1	0	0	0	0	1	0	0	0	2809	1291	45	3	1600	3	CCDC37	3	126153142	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08	23995769	126153142	71869288	19	5008											
B3GALNT1	8706	broad.mit.edu	37	chr3	160804500	160804500	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gctccatttgagggatctcaGtgacatcctactcggaagga	11	10	1	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr3:160804500G>C	uc003fdv.2	-	5	462	c.43C>G	c.(43-45)CTG>GTG	p.L15V	B3GALNT1_uc003fdw.2_Missense_Mutation_p.L15V|B3GALNT1_uc003fdx.2_Missense_Mutation_p.L15V|B3GALNT1_uc003fdy.2_Missense_Mutation_p.L15V|B3GALNT1_uc003fdz.2_Missense_Mutation_p.L15V|B3GALNT1_uc003fea.2_Missense_Mutation_p.L15V|B3GALNT1_uc011bpa.1_Missense_Mutation_p.L15V	NM_033169	NP_149359	O75752	B3GL1_HUMAN	UDP-Gal:betaGlcNAc beta	15	Cytoplasmic (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			AGGGATCTCAGTGACATCCTA	0.527													C	160804500	C	C	160804500	3	2	75	1	0	0	0	0	1	0	0	0	1245	1020	36	5	956	5	B3GALNT1	3	160804500	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08	34651358	160804500	37217930	20	5009											
ZNF391	346157	broad.mit.edu	37	chr6	27368167	27368167	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcaatggaaagcctcagaggGaatactgctcagggtcctac	12	10	2	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr6:27368167G>A	uc003njf.1	+	3	536	c.18G>A	c.(16-18)GGG>GGA	p.G6G		NM_001076781	NP_001070249	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	6					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(2)|skin(1)	3						GCCTCAGAGGGAATACTGCTC	0.423													A	27368167	A	A	27368167	2	1	75	1	0	0	0	0	0	0	0	1	17876	1161	41	3		3	ZNF391	6	27368167	Silent	SNP	G	TCGA-06-2557-01A-01D-1494-08		27368167	143746900	21	5010											
CCHCR1	54535	broad.mit.edu	37	chr6	31124628	31124628	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatggcctgggggttggaccAggggaatgtctgagagccag	19	7	1	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr6:31124628A>G	uc003nsr.3	-	3	233	c.110T>C	c.(109-111)CTG>CCG	p.L37P	CCHCR1_uc011dne.1_Missense_Mutation_p.L37P|CCHCR1_uc003nsq.3_Intron|CCHCR1_uc003nsp.3_Missense_Mutation_p.L126P|CCHCR1_uc010jsk.1_Missense_Mutation_p.L37P|TCF19_uc003nss.2_5'Flank|TCF19_uc003nst.2_5'Flank	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	37					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						GGGTTGGACCAGGGGAATGTC	0.577													G	31124628	G	G	31124628	3	3	75	1	0	0	0	0	1	0	0	0	2877	188	7	4	2302	4	CCHCR1	6	31124628	Missense_Mutation	SNP	A	TCGA-06-2557-01A-01D-1494-08	3756461	31124628	139990439	22	5011											
TREML2	79865	broad.mit.edu	37	chr6	41166083	41166083	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttgccctccacgcggtttTtgtagcccttataggagcac	9	14	0	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr6:41166083T>C	uc010jxm.1	-	2	319	c.140A>G	c.(139-141)AAA>AGA	p.K47R		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	47	Ig-like V-type.|Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					CACGCGGTTTTTGTAGCCCTT	0.537													C	41166083	C	C	41166083	3	2	75	1	0	0	0	0	1	0	0	0	16470	1841	64	4	841	4	TREML2	6	41166083	Missense_Mutation	SNP	T	TCGA-06-2557-01A-01D-1494-08	10041455	41166083	129948984	23	5012											
C6orf138	442213	broad.mit.edu	37	chr6	47846894	47846894	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttgttattggcactgacGttgctgactttcaggaactg	10	8	1	2	rs147985171	byFrequency	TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr6:47846894G>A	uc011dwm.1	-	3	1720	c.1635C>T	c.(1633-1635)AAC>AAT	p.N545N	C6orf138_uc011dwn.1_Silent_p.N309N	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	562						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						TGGCACTGACGTTGCTGACTT	0.443													A	47846894	A	A	47846894	2	1	75	1	0	0	0	0	0	0	0	1	2332	1136	40	1		1	C6orf138	6	47846894	Silent	SNP	G	TCGA-06-2557-01A-01D-1494-08	6680811	47846894	123268173	24	5013											
SGK1	6446	broad.mit.edu	37	chr6	134493394	134493394	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atgttctccttgcagagtccGaagtcagtaaggacaatgtg	11	8	2	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr6:134493394G>A	uc003qen.3	-	8	812	c.723C>T	c.(721-723)TTC>TTT	p.F241F	SGK1_uc003qeo.3_Silent_p.F336F|SGK1_uc011ect.1_Silent_p.F231F|SGK1_uc011ecu.1_Silent_p.F197F|SGK1_uc011ecv.1_Silent_p.F255F|SGK1_uc011ecw.1_Silent_p.F269F	NM_005627	NP_005618	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1 isoform	241	Protein kinase.				apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(3)|stomach(1)|lung(1)|central_nervous_system(1)	6	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		TGCAGAGTCCGAAGTCAGTAA	0.448													A	134493394	A	A	134493394	2	1	75	1	0	0	0	0	0	0	0	1	14207	1049	37	2		2	SGK1	6	134493394	Silent	SNP	G	TCGA-06-2557-01A-01D-1494-08	86646500	134493394	36621673	25	5014											
KBTBD2	25948	broad.mit.edu	37	chr7	32909459	32909459	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgaagcaaaggacctactaGtctgtctcatggccatttct	8	11	3	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr7:32909459G>T	uc003tdb.2	-	4	2029	c.1370C>A	c.(1369-1371)ACT>AAT	p.T457N	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	457	Kelch 3.										0			GBM - Glioblastoma multiforme(11;0.0499)			GGACCTACTAGTCTGTCTCAT	0.438													T	32909459	T	T	32909459	3	4	75	1	0	0	0	0	1	0	0	0	7993	1029	36	5	505	5	KBTBD2	7	32909459	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08		32909459	126229204	26	5015											
IKZF1	10320	broad.mit.edu	37	chr7	50467932	50467932	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctcggagcgcgaggcgtcCccgagcaacagctgccaaga	13	16	0	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr7:50467932C>T	uc003tow.3	+	9	1335	c.1167C>T	c.(1165-1167)TCC>TCT	p.S389S	IKZF1_uc003tox.3_Silent_p.S347S|IKZF1_uc003toy.3_Silent_p.S347S|IKZF1_uc011kck.1_Silent_p.S302S|IKZF1_uc003toz.3_Silent_p.S359S|IKZF1_uc010kyx.2_Silent_p.S129S|IKZF1_uc003tpa.3_Silent_p.S131S	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	389					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GCGAGGCGTCCCCGAGCAACA	0.672			D		ALL								T	50467932	T	T	50467932	2	4	75	1	0	0	0	0	0	0	0	1	7614	610	22	3		3	IKZF1	7	50467932	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	17558473	50467932	108670731	27	5016											
EGFR	1956	broad.mit.edu	37	chr7	55221821	55221821	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggcaaatacagctttggtGccacctgcgtgaagaagtgt	13	8	0	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr7:55221821G>A	uc003tqk.2	+	7	1111	c.865G>A	c.(865-867)GCC>ACC	p.A289T	EGFR_uc003tqh.2_Missense_Mutation_p.A289T|EGFR_uc003tqi.2_Missense_Mutation_p.A289T|EGFR_uc003tqj.2_Missense_Mutation_p.A289T|EGFR_uc010kzg.1_Missense_Mutation_p.A244T|EGFR_uc011kco.1_Missense_Mutation_p.A236T|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTTTGGTGCCACCTGCGT	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55221821	A	A	55221821	3	1	75	1	0	0	0	0	1	0	0	0	4967	1319	46	3	891	3	EGFR	7	55221821	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08	4753889	55221821	103916842	28	5017											
SEMA3C	10512	broad.mit.edu	37	chr7	80387708	80387708	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggcgcaataagggtcccGcgccaggcagcagtcagcac	13	15	1	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr7:80387708G>A	uc003uhj.2	-	15	2144	c.1582C>T	c.(1582-1584)CGG>TGG	p.R528W	SEMA3C_uc011kgw.1_Missense_Mutation_p.R546W	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	528					immune response|response to drug	membrane	receptor activity			ovary(1)	1						TAAGGGTCCCGCGCCAGGCAG	0.527													A	80387708	A	A	80387708	3	1	75	1	0	0	0	0	1	0	0	0	14026	1086	38	1	689	1	SEMA3C	7	80387708	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08	25165887	80387708	78750955	29	5018											
NPTX2	4885	broad.mit.edu	37	chr7	98257875	98257875	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccgtgggtggacaataacgtCgatgtgttcggaggggcctc	16	9	0	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr7:98257875C>T	uc003upl.2	+	5	1407	c.1230C>T	c.(1228-1230)GTC>GTT	p.V410V		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	410	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			ACAATAACGTCGATGTGTTCG	0.582													T	98257875	T	T	98257875	2	4	75	1	0	0	0	0	0	0	0	1	10603	871	31	2		2	NPTX2	7	98257875	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	17870167	98257875	60880788	30	5019											
C7orf51	222950	broad.mit.edu	37	chr7	100085924	100085924	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gaggggggaacctgcctcttCagcgcctcactagggggtcc	15	13	3	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr7:100085924C>A	uc003uvd.1	+	4	739	c.580C>A	c.(580-582)CAG>AAG	p.Q194K	C7orf51_uc003uve.1_5'UTR	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	194										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCTGCCTCTTCAGCGCCTCAC	0.637													A	100085924	A	A	100085924	3	1	75	1	0	0	0	0	1	0	0	0	2400	827	29	5	590	5	C7orf51	7	100085924	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	1828049	100085924	59052739	31	5020											
MUC17	140453	broad.mit.edu	37	chr7	100678887	100678887	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctagtgaaggaaccactcCgttaacaagtatacctgtca	7	11	1	1	rs141608296		TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr7:100678887C>T	uc003uxp.1	+	3	4243	c.4190C>T	c.(4189-4191)CCG>CTG	p.P1397L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1397	Extracellular (Potential).|59 X approximate tandem repeats.|21.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGAACCACTCCGTTAACAAGT	0.507													T	100678887	T	T	100678887	3	4	75	1	0	0	0	0	1	0	0	0	9974	652	23	2	4200	2	MUC17	7	100678887	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	592963	100678887	58459776	32	5021											
FIS1	51024	broad.mit.edu	37	chr7	100887381	100887381	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgtgctcttggacaccgAgcctgctgccttctcagact	10	15	2	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr7:100887381A>T	uc003uyj.3	-	2	171	c.85T>A	c.(85-87)TCG>ACG	p.S29T	FIS1_uc010lht.2_RNA|FIS1_uc010lhu.2_Intron	NM_016068	NP_057152	Q9Y3D6	FIS1_HUMAN	tetratricopeptide repeat domain 11	29	Cytoplasmic (Potential).				apoptosis|mitochondrial fission|peroxisome fission	integral to mitochondrial outer membrane|integral to peroxisomal membrane	protein binding				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TTGGACACCGAGCCTGCTGCC	0.512											OREG0018218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	100887381	T	T	100887381	3	4	75	1	0	0	0	0	1	0	0	0	5897	304	11	5	389	5	FIS1	7	100887381	Missense_Mutation	SNP	A	TCGA-06-2557-01A-01D-1494-08	208494	100887381	58251282	33	5022											
DUS4L	11062	broad.mit.edu	37	chr7	107214222	107214222	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatgctgctcgtatagtctgTccttatgcgaatggaataga	11	7	1	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr7:107214222T>G	uc003veh.2	+	5	645	c.312T>G	c.(310-312)TGT>TGG	p.C104W	DUS4L_uc003veg.2_Intron|DUS4L_uc011klw.1_Intron|DUS4L_uc011klx.1_5'UTR|DUS4L_uc010ljl.2_5'Flank	NM_181581	NP_853559	O95620	DUS4L_HUMAN	dihydrouridine synthase 4-like	104					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0						GTATAGTCTGTCCTTATGCGA	0.383													G	107214222	G	G	107214222	3	3	75	1	0	0	0	0	1	0	0	0	4808	1673	58	5	322	5	DUS4L	7	107214222	Missense_Mutation	SNP	T	TCGA-06-2557-01A-01D-1494-08	6326841	107214222	51924441	34	5023											
RHOBTB2	23221	broad.mit.edu	37	chr8	22864290	22864290	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagaagggtcgggaggtgGccaaggagctgggcatcccc	18	10	0	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr8:22864290G>A	uc003xcq.2	+	5	1069	c.532G>A	c.(532-534)GCC>ACC	p.A178T	RHOBTB2_uc003xcp.2_Missense_Mutation_p.A200T|RHOBTB2_uc011kzp.1_Missense_Mutation_p.A185T|uc003xcr.2_RNA	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	178	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		TCGGGAGGTGGCCAAGGAGCT	0.577													A	22864290	A	A	22864290	3	1	75	1	0	0	0	0	1	0	0	0	13334	1203	42	3	631	3	RHOBTB2	8	22864290	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08		22864290	123499732	35	5024											
TEX15	56154	broad.mit.edu	37	chr8	30699744	30699744	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctcttcagctgtaaaatctTccttctgttatacagcattt	4	10	4	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr8:30699744T>C	uc003xil.2	-	1	6790	c.6790A>G	c.(6790-6792)AAG>GAG	p.K2264E		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2264										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TGTAAAATCTTCCTTCTGTTA	0.313													C	30699744	C	C	30699744	3	2	75	1	0	0	0	0	1	0	0	0	15776	1792	62	4	1595	4	TEX15	8	30699744	Missense_Mutation	SNP	T	TCGA-06-2557-01A-01D-1494-08	7835454	30699744	115664278	36	5025											
PLEC	5339	broad.mit.edu	37	chr8	144993481	144993481	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtgtcgtcgctggggtccGccaggacgcggttcatctcc	15	13	2	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr8:144993481G>A	uc003zaf.1	-	32	11089	c.10919C>T	c.(10918-10920)GCG>GTG	p.A3640V	PLEC_uc003zab.1_Missense_Mutation_p.A3503V|PLEC_uc003zac.1_Missense_Mutation_p.A3507V|PLEC_uc003zad.2_Missense_Mutation_p.A3503V|PLEC_uc003zae.1_Missense_Mutation_p.A3471V|PLEC_uc003zag.1_Missense_Mutation_p.A3481V|PLEC_uc003zah.2_Missense_Mutation_p.A3489V|PLEC_uc003zaj.2_Missense_Mutation_p.A3530V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3640	Globular 2.|Plectin 16.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCTGGGGTCCGCCAGGACGCG	0.662													A	144993481	A	A	144993481	3	1	75	1	0	0	0	0	1	0	0	0	12052	1087	38	1	3139	1	PLEC	8	144993481	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08	114293737	144993481	1370541	37	5026											
CDKN2A	1029	broad.mit.edu	37	chr9	21971124	21971125	+	Frame_Shift_Del	DEL	GA	-	-													gcgtcgtgcacgggtcgggtGagagtggcggggtcggcgca							TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr9:21971124_21971125delGA	uc003zpk.2	-	2	445_446	c.233_234delTC	c.(232-234)CTCfs	p.L78fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Frame_Shift_Del_p.S133fs	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	78	ANK 3.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.L78fs*41(17)|p.?(13)|p.E61_L94del(1)|p.L78fs*68(1)|p.A76fs*64(1)|p.T79fs*41(1)|p.L65fs*38(1)|p.L78fs*67(1)|p.A68fs*3(1)|p.L78H(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGGGTCGGGTGAGAGTGGCGGG	0.723		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			-	21971125	-	-	21971124	7	5	75	1	0	1	0	1	0	0	0	0	3161	1290	45	0	244	0	CDKN2A	9	21971124	Frame_Shift_Del	DEL	GA	TCGA-06-2557-01A-01D-1494-08		21971124	119242307	38	5027											
AKR1C1	1645	broad.mit.edu	37	chr10	5014817	5014817	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gctcttggaggacccagtccTttgtgccttggcaaaaaagc	11	11	1	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr10:5014817T>A	uc001iho.2	+	12	1563	c.722T>A	c.(721-723)CTT>CAT	p.L241H	AKR1E2_uc001ihl.1_Intron|AKR1C2_uc010qan.1_Intron|AKR1C3_uc001ihr.2_Intron|AKR1C1_uc001ihq.2_Missense_Mutation_p.L241H	NM_001353	NP_001344	Q04828	AK1C1_HUMAN	aldo-keto reductase family 1, member C1	241	NADP (By similarity).				bile acid and bile salt transport|bile acid metabolic process|cholesterol homeostasis|intestinal cholesterol absorption|protein homooligomerization|response to organophosphorus|xenobiotic metabolic process	cytosol	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid binding|indanol dehydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			ovary(2)	2					NADH(DB00157)	GACCCAGTCCTTTGTGCCTTG	0.592													A	5014817	A	A	5014817	3	1	75	1	0	0	0	0	1	0	0	0	469	1609	56	5	748	5	AKR1C1	10	5014817	Missense_Mutation	SNP	T	TCGA-06-2557-01A-01D-1494-08		5014817	130519930	39	5028											
SORCS3	22986	broad.mit.edu	37	chr10	107015536	107015536	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccgggggtacaagtcattgTgtatgtcacacagctgacgt	13	9	2	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr10:107015536T>G	uc001kyi.1	+	24	3541	c.3314T>G	c.(3313-3315)GTG>GGG	p.V1105G		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1105	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAAGTCATTGTGTATGTCACA	0.438													G	107015536	G	G	107015536	3	3	75	1	0	0	0	0	1	0	0	0	14932	1696	59	5	3408	5	SORCS3	10	107015536	Missense_Mutation	SNP	T	TCGA-06-2557-01A-01D-1494-08	102000719	107015536	28519211	40	5029											
MADD	8567	broad.mit.edu	37	chr11	47307122	47307122	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accagcaccgagggcttcggGggcatcatgtcttttgccag	13	12	2	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr11:47307122G>A	uc001ner.1	+	14	2723	c.2532G>A	c.(2530-2532)GGG>GGA	p.G844G	MADD_uc001neq.2_Silent_p.G844G|MADD_uc001nev.1_Silent_p.G801G|MADD_uc001nes.1_Silent_p.G801G|MADD_uc001net.1_Silent_p.G844G|MADD_uc009yln.1_Silent_p.G801G|MADD_uc001neu.1_Silent_p.G801G|MADD_uc001nex.2_Silent_p.G844G|MADD_uc001nez.2_Silent_p.G801G|MADD_uc001new.2_Silent_p.G844G	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	844					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		AGGGCTTCGGGGGCATCATGT	0.532													A	47307122	A	A	47307122	2	1	75	1	0	0	0	0	0	0	0	1	9152	1219	43	3		3	MADD	11	47307122	Silent	SNP	G	TCGA-06-2557-01A-01D-1494-08		47307122	87699394	41	5030											
OR5T3	390154	broad.mit.edu	37	chr11	56019879	56019879	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tttgcaatctatctctttacCttgataggcaatttagggct	7	8	2	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr11:56019879C>A	uc010rjd.1	+	1	204	c.204C>A	c.(202-204)ACC>ACA	p.T68T		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	68	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					ATCTCTTTACCTTGATAGGCA	0.373													A	56019879	A	A	56019879	2	1	75	1	0	0	0	0	0	0	0	1	11183	668	24	5		5	OR5T3	11	56019879	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	8712757	56019879	78986637	42	5031											
MS4A3	932	broad.mit.edu	37	chr11	59834575	59834575	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctatgcaattacatgggctCcatatcaaatgtatgtttct	6	9	2	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr11:59834575C>T	uc001nom.2	+	5	631	c.503C>T	c.(502-504)TCC>TTC	p.S168F	MS4A3_uc001non.2_Missense_Mutation_p.S122F|MS4A3_uc001noo.2_Missense_Mutation_p.S45F	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	168	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				TACATGGGCTCCATATCAAAT	0.343													T	59834575	T	T	59834575	3	4	75	1	0	0	0	0	1	0	0	0	9861	855	30	3	517	3	MS4A3	11	59834575	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	3814696	59834575	75171941	43	5032											
AHNAK	79026	broad.mit.edu	37	chr11	62300927	62300927	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctttggtgtctggcccTcacgccctgttgagacacca	10	15	2	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr11:62300927T>G	uc001ntl.2	-	5	1262	c.962A>C	c.(961-963)GAG>GCG	p.E321A	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	321					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGTCTGGCCCTCACGCCCTGT	0.552													G	62300927	G	G	62300927	3	3	75	1	0	0	0	0	1	0	0	0	414	1551	54	5	16830	5	AHNAK	11	62300927	Missense_Mutation	SNP	T	TCGA-06-2557-01A-01D-1494-08	2466352	62300927	72705589	44	5033											
FLRT1	23769	broad.mit.edu	37	chr11	63884137	63884137	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgctccctccgggagctgcAcctgcaggacaacaatgtgc	11	16	0	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr11:63884137A>G	uc001nyi.1	+	2	739	c.398A>G	c.(397-399)CAC>CGC	p.H133R	MACROD1_uc001nyh.2_Intron	NM_013280	NP_037412	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein	105	LRR 3.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity				0						CGGGAGCTGCACCTGCAGGAC	0.602													G	63884137	G	G	63884137	3	3	75	1	0	0	0	0	1	0	0	0	5938	159	6	4	400	4	FLRT1	11	63884137	Missense_Mutation	SNP	A	TCGA-06-2557-01A-01D-1494-08	1583210	63884137	71122379	45	5034											
KAT5	10524	broad.mit.edu	37	chr11	65482151	65482151	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaactcaccacattgcctgtCctctacctgtgcgagttctg	8	14	3	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr11:65482151C>T	uc001ofi.2	+	8	1027	c.777C>T	c.(775-777)GTC>GTT	p.V259V	KAT5_uc001ofj.2_Silent_p.V207V|KAT5_uc001ofk.2_Silent_p.V292V|KAT5_uc010roo.1_Silent_p.V240V|KAT5_uc001ofl.2_Silent_p.V48V	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	259					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						CATTGCCTGTCCTCTACCTGT	0.582													T	65482151	T	T	65482151	2	4	75	1	0	0	0	0	0	0	0	1	7983	842	30	3		3	KAT5	11	65482151	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	1598014	65482151	69524365	46	5035											
APOBEC1	339	broad.mit.edu	37	chr12	7805333	7805333	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgagcttcgccagatcttcCggctcatgccccacttgatt	8	15	2	3	rs149648198		TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr12:7805333C>T	uc001qtb.2	-	3	177	c.143G>A	c.(142-144)CGG>CAG	p.R48Q	APOBEC1_uc001qtc.2_Missense_Mutation_p.R3Q|APOBEC1_uc010sgf.1_Missense_Mutation_p.R48Q	NM_001644	NP_001635	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme	48					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding				0						CCAGATCTTCCGGCTCATGCC	0.453													T	7805333	T	T	7805333	3	4	75	1	0	0	0	0	1	0	0	0	787	652	23	2	579	2	APOBEC1	12	7805333	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08		7805333	126046562	47	5036											
ATF7IP	55729	broad.mit.edu	37	chr12	14589059	14589059	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gatgaattttctagacgaaaAcgttctaaatcagaagacat	7	6	3	4	rs141409610		TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr12:14589059A>T	uc001rbw.2	+	4	1823	c.1665A>T	c.(1663-1665)AAA>AAT	p.K555N	ATF7IP_uc010shs.1_Missense_Mutation_p.K554N|ATF7IP_uc001rbu.2_Missense_Mutation_p.K555N|ATF7IP_uc001rbv.1_Missense_Mutation_p.K554N|ATF7IP_uc001rbx.2_Missense_Mutation_p.K554N|ATF7IP_uc010sht.1_Missense_Mutation_p.K555N|ATF7IP_uc001rby.3_Missense_Mutation_p.K555N|ATF7IP_uc001rca.2_Missense_Mutation_p.K555N	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	555	Glu-rich.|Nuclear localization signal (By similarity).				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						CTAGACGAAAACGTTCTAAAT	0.348													T	14589059	T	T	14589059	3	4	75	1	0	0	0	0	1	0	0	0	1087	40	2	5	1675	5	ATF7IP	12	14589059	Missense_Mutation	SNP	A	TCGA-06-2557-01A-01D-1494-08	6783726	14589059	119262836	48	5037											
FAM113B	91523	broad.mit.edu	37	chr12	47629951	47629951	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcccatgcaggtttcttcGtcgaagacaattttatggtt	9	9	1	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr12:47629951G>A	uc001rpn.2	+	4	1836	c.1105G>A	c.(1105-1107)GTC>ATC	p.V369I	FAM113B_uc001rpq.2_Missense_Mutation_p.V369I	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	369	Pro-rich.						hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					AGGTTTCTTCGTCGAAGACAA	0.527													A	47629951	A	A	47629951	3	1	75	1	0	0	0	0	1	0	0	0	5402	1145	40	1	1107	1	FAM113B	12	47629951	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08	33040892	47629951	86221944	49	5038											
KRT84	3890	broad.mit.edu	37	chr12	52779219	52779219	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtgatgacactccgactacCaaagctgccaaggccccgga	11	14	0	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr12:52779219C>A	uc001sah.1	-	1	199	c.151G>T	c.(151-153)GGT>TGT	p.G51C		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	51	Head.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CTCCGACTACCAAAGCTGCCA	0.582													A	52779219	A	A	52779219	3	1	75	1	0	0	0	0	1	0	0	0	8498	594	21	5	1687	5	KRT84	12	52779219	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	5149268	52779219	81072676	50	5039											
KRT76	51350	broad.mit.edu	37	chr12	53164870	53164870	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatcagctcctggtagtcaCgcaggagccgagccaggtca	12	13	4	0	rs143394911	byFrequency	TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr12:53164870C>T	uc001sax.2	-	7	1451	c.1397G>A	c.(1396-1398)CGT>CAT	p.R466H		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	466	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						CTGGTAGTCACGCAGGAGCCG	0.602													T	53164870	T	T	53164870	3	4	75	1	0	0	0	0	1	0	0	0	8489	536	19	1	531	1	KRT76	12	53164870	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	385651	53164870	80687025	51	5040											
MMAB	326625	broad.mit.edu	37	chr12	109994906	109994906	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattcccctccttcatggctGcatatctggctagcgtgaag	10	12	2	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr12:109994906G>A	uc001tou.2	-	9	753	c.680C>T	c.(679-681)GCA>GTA	p.A227V	MMAB_uc001tov.2_RNA|MMAB_uc001tow.2_RNA|MMAB_uc010sxq.1_Missense_Mutation_p.A136V|MMAB_uc001tox.2_Missense_Mutation_p.A175V	NM_052845	NP_443077	Q96EY8	MMAB_HUMAN	cob(I)alamin adenosyltransferase precursor	227					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity				0					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTTCATGGCTGCATATCTGGC	0.473													A	109994906	A	A	109994906	3	1	75	1	0	0	0	0	1	0	0	0	9640	1319	46	3	76	3	MMAB	12	109994906	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08	56830036	109994906	23856989	52	5041											
ZNF410	57862	broad.mit.edu	37	chr14	74360573	74360573	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaatcagaagctaaagataTtacttgcttgtccctccttc	6	10	1	3			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr14:74360573T>C	uc001xoz.1	+	3	289	c.107T>C	c.(106-108)ATT>ACT	p.I36T	ZNF410_uc001xoy.1_RNA|ZNF410_uc010ary.1_RNA|ZNF410_uc010tuf.1_RNA|ZNF410_uc010tug.1_5'UTR|ZNF410_uc010tuh.1_Missense_Mutation_p.I36T|ZNF410_uc010tui.1_RNA|ZNF410_uc010arz.1_Missense_Mutation_p.I36T|ZNF410_uc001xpa.1_5'UTR|ZNF410_uc001xpb.1_Missense_Mutation_p.I36T|ZNF410_uc001xpc.1_5'UTR	NM_021188	NP_067011	Q86VK4	ZN410_HUMAN	zinc finger protein 410	36					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00369)		GCTAAAGATATTACTTGCTTG	0.443													C	74360573	C	C	74360573	3	2	75	1	0	0	0	0	1	0	0	0	17887	1493	52	4	113	4	ZNF410	14	74360573	Missense_Mutation	SNP	T	TCGA-06-2557-01A-01D-1494-08		74360573	32988967	53	5042											
GPR65	8477	broad.mit.edu	37	chr14	88478073	88478073	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attctgtactgttttgtaacCgaaacaggaagatatgatat	8	5	1	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr14:88478073C>T	uc001xvv.2	+	2	1412	c.882C>T	c.(880-882)ACC>ACT	p.T294T		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	294	Helical; Name=7; (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						GTTTTGTAACCGAAACAGGAA	0.353													T	88478073	T	T	88478073	2	4	75	1	0	0	0	0	0	0	0	1	6706	639	23	2		2	GPR65	14	88478073	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	14117500	88478073	18871467	54	5043											
DICER1	23405	broad.mit.edu	37	chr14	95557393	95557393	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaatttggcagtttctggttCcatttcaagcaattctcgca	7	9	3	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr14:95557393C>T	uc001ydw.2	-	27	5763	c.5581G>A	c.(5581-5583)GAA>AAA	p.E1861K	DICER1_uc010avh.1_Missense_Mutation_p.E759K|DICER1_uc001ydv.2_Missense_Mutation_p.E1851K|DICER1_uc001ydx.2_Missense_Mutation_p.E1861K	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1861	DRBM.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GTTTCTGGTTCCATTTCAAGC	0.323			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				T	95557393	T	T	95557393	3	4	75	1	0	0	0	0	1	0	0	0	4521	864	30	3	195	3	DICER1	14	95557393	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	7079320	95557393	11792147	55	5044											
ZSCAN2	54993	broad.mit.edu	37	chr15	85164337	85164337	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaggatccacacgggggaaaAgcccttccagtgtgccgagt	14	11	0	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr15:85164337A>G	uc002bkr.2	+	3	1137	c.911A>G	c.(910-912)AAG>AGG	p.K304R	ZSCAN2_uc010bmz.1_Missense_Mutation_p.K302R|ZSCAN2_uc010bna.2_Missense_Mutation_p.K154R|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	304					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		ACGGGGGAAAAGCCCTTCCAG	0.577													G	85164337	G	G	85164337	3	3	75	1	0	0	0	0	1	0	0	0	18228	72	3	4	1007	4	ZSCAN2	15	85164337	Missense_Mutation	SNP	A	TCGA-06-2557-01A-01D-1494-08		85164337	17367055	56	5045											
PDZD9	255762	broad.mit.edu	37	chr16	21995750	21995750	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccctcacttctttcttgtcGtctctgtgaatcatcacgtc	6	14	6	1	rs146108684	byFrequency	TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr16:21995750G>A	uc002dka.1	-	5	764	c.447C>T	c.(445-447)GAC>GAT	p.D149D		NM_173806	NP_776167	Q8IXQ8	PDZD9_HUMAN	hypothetical protein LOC255762	211										pancreas(1)	1						CTTTCTTGTCGTCTCTGTGAA	0.423													A	21995750	A	A	21995750	2	1	75	1	0	0	0	0	0	0	0	1	11706	1136	40	1		1	PDZD9	16	21995750	Silent	SNP	G	TCGA-06-2557-01A-01D-1494-08		21995750	68359003	57	5046											
IL27	246778	broad.mit.edu	37	chr16	28515112	28515112	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcctggcaggtgagattcCgcctggggggcaaggtctgt	16	10	1	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr16:28515112C>T	uc002dqc.2	-	3	230	c.207G>A	c.(205-207)GCG>GCA	p.A69A	uc010vct.1_Intron	NM_145659	NP_663634	Q8NEV9	IL27A_HUMAN	interleukin 27 precursor	69					inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding				0						GGTGAGATTCCGCCTGGGGGG	0.632													T	28515112	T	T	28515112	2	4	75	1	0	0	0	0	0	0	0	1	7680	639	23	2		2	IL27	16	28515112	Silent	SNP	C	TCGA-06-2557-01A-01D-1494-08	6519362	28515112	61839641	58	5047											
HEATR3	55027	broad.mit.edu	37	chr16	50106625	50106625	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgacctggctatttcagtaGgtaagtgaagaaaaggtgat	12	4	1	4			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr16:50106625G>A	uc002efw.2	+	5	784	c.622G>A	c.(622-624)GCA>ACA	p.A208T	HEATR3_uc002efx.2_Missense_Mutation_p.A122T	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	208							binding			ovary(1)|skin(1)	2						TATTTCAGTAGGTAAGTGAAG	0.348													A	50106625	A	A	50106625	3	1	75	1	0	0	0	0	1	0	0	0	7029	1014	35	3	640	3	HEATR3	16	50106625	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08	21591513	50106625	40248128	59	5048											
RABEP1	9135	broad.mit.edu	37	chr17	5286437	5286437	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcagttagagcggatccgGcaagctgactccttggagag	15	9	0	3			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr17:5286437G>A	uc002gbm.3	+	18	2732	c.2508G>A	c.(2506-2508)CGG>CGA	p.R836R	RABEP1_uc010vsw.1_Silent_p.R793R|RABEP1_uc002gbl.3_Silent_p.R803R|NUP88_uc002gbn.2_Intron	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	836					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2						AGCGGATCCGGCAAGCTGACT	0.473													A	5286437	A	A	5286437	2	1	75	1	0	0	0	0	0	0	0	1	12961	1190	42	3		3	RABEP1	17	5286437	Silent	SNP	G	TCGA-06-2557-01A-01D-1494-08		5286437	75908773	60	5049											
MYH13	8735	broad.mit.edu	37	chr17	10215363	10215363	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttccaactcagcctggctttCgtccagcttttgcttccact	6	15	1	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr17:10215363C>T	uc002gmk.1	-	32	4486	c.4396G>A	c.(4396-4398)GAA>AAA	p.E1466K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1466	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GCCTGGCTTTCGTCCAGCTTT	0.517													T	10215363	T	T	10215363	3	4	75	1	0	0	0	0	1	0	0	0	10032	893	31	2	1460	2	MYH13	17	10215363	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	4928926	10215363	70979847	61	5050											
ATG4D	84971	broad.mit.edu	37	chr19	10655709	10655709	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgggacttcccgccccttccTgggggctgcctgacctcgga	13	17	0	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr19:10655709T>G	uc002mov.2	+	3	516	c.396T>G	c.(394-396)CCT>CCG	p.P132P	ATG4D_uc010xlg.1_Silent_p.P155P|ATG4D_uc010xlh.1_Silent_p.P69P|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_5'UTR	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	132					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CGCCCCTTCCTGGGGGCTGCC	0.632													G	10655709	G	G	10655709	2	3	75	1	0	0	0	0	0	0	0	1	1099	1567	55	5		5	ATG4D	19	10655709	Silent	SNP	T	TCGA-06-2557-01A-01D-1494-08		10655709	48473274	62	5051											
ZNF208	7757	broad.mit.edu	37	chr19	22156647	22156647	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccacattcttcacatttgtAgggtttctctccagtatgaa	7	10	3	1			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr19:22156647A>G	uc002nqp.2	-	4	1338	c.1189T>C	c.(1189-1191)TAC>CAC	p.Y397H	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCACATTTGTAGGGTTTCTCT	0.388													G	22156647	G	G	22156647	3	3	75	1	0	0	0	0	1	0	0	0	17763	420	15	4	2657	4	ZNF208	19	22156647	Missense_Mutation	SNP	A	TCGA-06-2557-01A-01D-1494-08	11500938	22156647	36972336	63	5052											
TRPM4	54795	broad.mit.edu	37	chr19	49671909	49671910	+	In_Frame_Ins	INS	-	GCA	GCA													cttcttcctggtggacgacgINSgcacacacggctgcctgggg							TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr19:49671909_49671910insGCA	uc002pmw.2	+	6	784_785	c.712_713insGCA	c.(712-714)GGC>GGCAGC	p.238_239insS	TRPM4_uc010emu.2_In_Frame_Ins_p.238_239insS|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_In_Frame_Ins_p.64_65insS|TRPM4_uc010emv.2_In_Frame_Ins_p.123_124insS|TRPM4_uc010yal.1_5'UTR	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	238_239	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGTGGACGACGGCACACACGGC	0.658													GCA	49671910	GCA	GCA	49671909	7	5	75	1	0	1	1	0	0	0	0	0	16585	1116	39	0	734	0	TRPM4	19	49671909	In_Frame_Ins	INS	-	TCGA-06-2557-01A-01D-1494-08	27515262	49671909	9457074	64	5053											
LENG1	79165	broad.mit.edu	37	chr19	54660572	54660573	+	Frame_Shift_Del	DEL	TC	-	-													ccttcatcaccgccgtgctgTctcttcttccccagatgctt							TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr19:54660572_54660573delTC	uc002qdm.2	-	3	516_517	c.503_504delGA	c.(502-504)AGAfs	p.R168fs		NM_024316	NP_077292	Q96BZ8	LENG1_HUMAN	leukocyte receptor cluster (LRC) member 1	168										ovary(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CGCCGTGCTGTCTCTTCTTCCC	0.634													-	54660573	-	-	54660572	7	5	75	1	0	1	0	1	0	0	0	0	8723	1664	58	0	298	0	LENG1	19	54660572	Frame_Shift_Del	DEL	TC	TCGA-06-2557-01A-01D-1494-08	4988663	54660572	4468411	65	5054											
NAPB	63908	broad.mit.edu	37	chr20	23383673	23383673	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aacatatttgcagctctggtAtacatttcacaagcctcttc	5	11	3	0			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr20:23383673A>T	uc002wta.2	-	2	252	c.135T>A	c.(133-135)TAT>TAA	p.Y45*	NAPB_uc002wtc.2_5'UTR|NAPB_uc002wtb.2_Nonsense_Mutation_p.Y45*|NAPB_uc002wtd.3_RNA|NAPB_uc010zst.1_Nonsense_Mutation_p.Y45*	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	45					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)					CAGCTCTGGTATACATTTCAC	0.338													T	23383673	T	T	23383673	4	4	75	1	0	0	0	0	0	1	0	0	10162	456	16	5	801	5	NAPB	20	23383673	Nonsense_Mutation	SNP	A	TCGA-06-2557-01A-01D-1494-08		23383673	39641847	66	5055											
MOCS3	27304	broad.mit.edu	37	chr20	49576077	49576077	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attcccccaaccacccccagCggagacagtgaccaactgcg	8	18	0	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr20:49576077C>T	uc002xvy.1	+	1	715	c.698C>T	c.(697-699)GCG>GTG	p.A233V	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	233					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						CCACCCCCAGCGGAGACAGTG	0.622													T	49576077	T	T	49576077	3	4	75	1	0	0	0	0	1	0	0	0	9692	768	27	1	700	1	MOCS3	20	49576077	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08	26192404	49576077	13449443	67	5056											
PRDM15	63977	broad.mit.edu	37	chr21	43279747	43279747	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgaccatgaccactgggcCcagctcgggacattcggagt	12	12	0	2			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr21:43279747C>T	uc002yzq.1	-	9	1096	c.985G>A	c.(985-987)GGC>AGC	p.G329S	PRDM15_uc002yzo.2_Missense_Mutation_p.G66S|PRDM15_uc002yzp.2_Missense_Mutation_p.G66S|PRDM15_uc002yzr.1_Missense_Mutation_p.G66S	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCACTGGGCCCAGCTCGGGA	0.597													T	43279747	T	T	43279747	3	4	75	1	0	0	0	0	1	0	0	0	12456	623	22	3	3630	3	PRDM15	21	43279747	Missense_Mutation	SNP	C	TCGA-06-2557-01A-01D-1494-08		43279747	4850148	68	5057											
SEC14L3	266629	broad.mit.edu	37	chr22	30857619	30857619	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgatctgcaccgagtgctcGtactgagtcttcacctggtc	10	12	3	2	rs139964800	byFrequency	TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chr22:30857619G>A	uc003ahy.2	-	10	923	c.834C>T	c.(832-834)TAC>TAT	p.Y278Y	SEC14L3_uc003ahz.2_Silent_p.Y201Y|SEC14L3_uc003aia.2_Silent_p.Y219Y|SEC14L3_uc003aib.2_Silent_p.Y219Y	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	278	GOLD.					integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	CCGAGTGCTCGTACTGAGTCT	0.517													A	30857619	A	A	30857619	2	1	75	1	0	0	0	0	0	0	0	1	13983	1140	40	1		1	SEC14L3	22	30857619	Silent	SNP	G	TCGA-06-2557-01A-01D-1494-08		30857619	20446947	69	5058											
MAGEB6	158809	broad.mit.edu	37	chrX	26212711	26212711	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttggtggtggcctttggcGttgaattgaaagaaatggat	14	3	0	3			TCGA-06-2557-01A-01D-1494-08	TCGA-06-2557-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c27290e4-6835-448a-abdc-df8ddd5f4630	7113eb4c-ea48-40a8-b75f-ed5df7b04ff0	g.chrX:26212711G>A	uc004dbr.2	+	2	897	c.748G>A	c.(748-750)GTT>ATT	p.V250I	MAGEB6_uc010ngc.1_Missense_Mutation_p.V30I	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	250	MAGE.									ovary(3)	3						GGCCTTTGGCGTTGAATTGAA	0.517													A	26212711	A	A	26212711	3	1	75	1	0	0	0	0	1	0	0	0	9179	1145	40	1	750	1	MAGEB6	23	26212711	Missense_Mutation	SNP	G	TCGA-06-2557-01A-01D-1494-08		26212711	129057849	70	5059											
AADACL4	343066	broad.mit.edu	37	chr1	12726621	12726621	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaggaccagggggtccgcGtgacatggtaccacctgtat	15	10	0	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:12726621G>A	uc001auf.2	+	4	1099	c.1099G>A	c.(1099-1101)GTG>ATG	p.V367M		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	367	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GGGGGTCCGCGTGACATGGTA	0.493													A	12726621	A	A	12726621	3	1	76	1	0	0	0	0	1	0	0	0	13	1145	40	1	1113	1	AADACL4	1	12726621	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08		12726621	236524000	1	5060											
CNKSR1	10256	broad.mit.edu	37	chr1	26507045	26507045	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctcgaggctctggctgtgCggtctctgggacaccaggag	16	12	2	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:26507045C>T	uc001bln.3	+	2	212	c.154C>T	c.(154-156)CGG>TGG	p.R52W	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Missense_Mutation_p.R52W|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	52	SAM.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TCTGGCTGTGCGGTCTCTGGG	0.622													T	26507045	T	T	26507045	3	4	76	1	0	0	0	0	1	0	0	0	3606	759	27	1	160	1	CNKSR1	1	26507045	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	13780424	26507045	222743576	2	5061											
CYP4B1	1580	broad.mit.edu	37	chr1	47264924	47264924	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acccactggctttttggacaTgccctcgaggtatgtggagg	13	10	0	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:47264924T>C	uc001cqm.3	+	1	255	c.171T>C	c.(169-171)CAT>CAC	p.H57H	CYP4B1_uc009vyl.1_5'UTR|CYP4B1_uc001cqn.3_Silent_p.H57H|CYP4B1_uc009vym.2_Silent_p.H57H|CYP4B1_uc010omk.1_5'UTR	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	57					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TTTTTGGACATGCCCTCGAGG	0.572													C	47264924	C	C	47264924	2	2	76	1	0	0	0	0	0	0	0	1	4185	1461	51	4		4	CYP4B1	1	47264924	Silent	SNP	T	TCGA-06-2558-01A-01D-1494-08	20757879	47264924	201985697	3	5062											
C1orf175	374977	broad.mit.edu	37	chr1	55166995	55166995	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgccgcacttcagcgaCgtgaggacctcacagagcga	12	14	2	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:55166995C>T	uc010ooe.1	+	19	3609	c.3285C>T	c.(3283-3285)GAC>GAT	p.D1095D	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.D613D|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Silent_p.D297D	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1095	HEAT 3.					integral to membrane	binding				0						ACTTCAGCGACGTGAGGACCT	0.592													T	55166995	T	T	55166995	2	4	76	1	0	0	0	0	0	0	0	1	2016	550	19	1		1	C1orf175	1	55166995	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08	7902071	55166995	194083626	4	5063											
CD101	9398	broad.mit.edu	37	chr1	117552685	117552685	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctcttacgcagtatataCgcagcgggtgcgaagcggag	13	10	1	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:117552685C>T	uc010oxb.1	+	2	315	c.257C>T	c.(256-258)ACG>ATG	p.T86M	CD101_uc009whd.2_Missense_Mutation_p.T86M|CD101_uc010oxc.1_Missense_Mutation_p.T86M|CD101_uc010oxd.1_Missense_Mutation_p.T86M	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	86	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GCAGTATATACGCAGCGGGTG	0.532													T	117552685	T	T	117552685	3	4	76	1	0	0	0	0	1	0	0	0	2962	536	19	1	263	1	CD101	1	117552685	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	62385690	117552685	131697936	5	5064											
ACP6	51205	broad.mit.edu	37	chr1	147119358	147119358	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccatcagggcaacctctcGgcacctgctcctgcagaaga	10	16	2	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:147119358G>A	uc001epr.2	-	10	1618	c.1154C>T	c.(1153-1155)CCG>CTG	p.P385L		NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	385					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					GCAACCTCTCGGCACCTGCTC	0.522													A	147119358	A	A	147119358	3	1	76	1	0	0	0	0	1	0	0	0	165	1116	39	2	136	2	ACP6	1	147119358	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	29566673	147119358	102131263	6	5065											
AQP10	89872	broad.mit.edu	37	chr1	154295505	154295505	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccatgtgcatcgttggaCgcctcccctgggtcaagctc	12	14	1	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:154295505C>T	uc001feu.2	+	3	320	c.280C>T	c.(280-282)CGC>TGC	p.R94C	AQP10_uc001fev.2_Missense_Mutation_p.R94C|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	94	Cytoplasmic (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CATCGTTGGACGCCTCCCCTG	0.468													T	154295505	T	T	154295505	3	4	76	1	0	0	0	0	1	0	0	0	822	536	19	1	290	1	AQP10	1	154295505	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	7176147	154295505	94955116	7	5066											
CAMK1G	57172	broad.mit.edu	37	chr1	209773439	209773439	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gacagcagcctggagaatgaGattgctgtgttgaaaaagtg	14	5	0	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:209773439G>A	uc001hhd.2	+	3	306	c.204G>A	c.(202-204)GAG>GAA	p.E68E	CAMK1G_uc001hhf.3_Silent_p.E68E|CAMK1G_uc001hhe.2_Silent_p.E68E	NM_020439	NP_065172	Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	68	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		TGGAGAATGAGATTGCTGTGT	0.453													A	209773439	A	A	209773439	2	1	76	1	0	0	0	0	0	0	0	1	2598	933	33	3		3	CAMK1G	1	209773439	Silent	SNP	G	TCGA-06-2558-01A-01D-1494-08	55477934	209773439	39477182	8	5067											
GJC2	57165	broad.mit.edu	37	chr1	228345795	228345795	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgagcaggagcggcgccgCgccctccgccgccgcccggg	16	19	1	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:228345795C>T	uc001hsk.2	+	2	511	c.336C>T	c.(334-336)CGC>CGT	p.R112R		NM_020435	NP_065168	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	112	Cytoplasmic (Potential).				cell death	connexon complex|integral to membrane					0		Prostate(94;0.0405)				Agcggcgccgcgccctccgcc	0.537													T	228345795	T	T	228345795	2	4	76	1	0	0	0	0	0	0	0	1	6415	755	27	1		1	GJC2	1	228345795	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08	18572356	228345795	20904826	9	5068											
OR2L8	391190	broad.mit.edu	37	chr1	248112821	248112821	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgttcctatggccaggttcTctttgctgtctaccacatga	8	11	2	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr1:248112821T>C	uc001idt.1	+	1	662	c.662T>C	c.(661-663)CTC>CCC	p.L221P	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GGCCAGGTTCTCTTTGCTGTC	0.463													C	248112821	C	C	248112821	3	2	76	1	0	0	0	0	1	0	0	0	11009	1551	54	4	664	4	OR2L8	1	248112821	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08	19767026	248112821	1137800	10	5069											
TTC15	51112	broad.mit.edu	37	chr2	3482694	3482694	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gatcttaaggatggatccaaGaaacgcagtggtaagatccc	11	8	1	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr2:3482694G>T	uc002qxm.1	+	11	2161	c.1955G>T	c.(1954-1956)AGA>ATA	p.R652I	TTC15_uc002qxn.1_Missense_Mutation_p.R652I|TTC15_uc010ewm.1_Missense_Mutation_p.R658I	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	652	TPR 3.						binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		ATGGATCCAAGAAACGCAGTG	0.532													T	3482694	T	T	3482694	3	4	76	1	0	0	0	0	1	0	0	0	16679	942	33	5	1993	5	TTC15	2	3482694	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08		3482694	239716679	11	5070											
RNF144A	9781	broad.mit.edu	37	chr2	7154885	7154885	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaattatgcaaagatataaaAagctacaatttgaaagaggt	7	3	0	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr2:7154885A>G	uc002qys.2	+	5	725	c.283A>G	c.(283-285)AAG>GAG	p.K95E	RNF144A_uc002qyt.2_Intron	NM_014746	NP_055561	P50876	R144A_HUMAN	ring finger protein 144	95	IBR-type.					Golgi apparatus|integral to membrane	ligase activity|zinc ion binding			ovary(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;0.226)		OV - Ovarian serous cystadenocarcinoma(76;0.195)		AAGATATAAAAAGCTACAATT	0.368													G	7154885	G	G	7154885	3	3	76	1	0	0	0	0	1	0	0	0	13445	15	1	4	293	4	RNF144A	2	7154885	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	3672191	7154885	236044488	12	5071											
THADA	63892	broad.mit.edu	37	chr2	43802136	43802136	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggatgctaagattctagaCagaaacatttccagcgttgg	10	8	1	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr2:43802136C>T	uc002rsw.3	-	11	1420	c.1068G>A	c.(1066-1068)CTG>CTA	p.L356L	THADA_uc002rsx.3_Silent_p.L356L|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Silent_p.L66L|THADA_uc002rta.2_Silent_p.L66L|THADA_uc002rtb.1_Silent_p.L356L|THADA_uc002rtc.3_Silent_p.L356L|THADA_uc002rtd.2_Silent_p.L356L	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	356							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AGATTCTAGACAGAAACATTT	0.373													T	43802136	T	T	43802136	2	4	76	1	0	0	0	0	0	0	0	1	15837	465	17	3		3	THADA	2	43802136	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08	36647251	43802136	199397237	13	5072											
TTC30B	150737	broad.mit.edu	37	chr2	178416069	178416069	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gaaaccaatggcttctttgtAtttgttttcctgcatgaaca	7	8	1	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr2:178416069A>T	uc002uln.2	-	1	1456	c.1423T>A	c.(1423-1425)TAC>AAC	p.Y475N	TTC30B_uc010zfc.1_Missense_Mutation_p.Y247N	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	475	TPR 7.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			GCTTCTTTGTATTTGTTTTCC	0.393													T	178416069	T	T	178416069	3	4	76	1	0	0	0	0	1	0	0	0	16696	449	16	5	578	5	TTC30B	2	178416069	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	134613933	178416069	64783304	14	5073											
MYO1B	4430	broad.mit.edu	37	chr2	192265141	192265141	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcgggaactgaagcatcaaAagcgctgtaaggaagcagtc	13	8	1	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr2:192265141A>G	uc010fsg.2	+	22	2584	c.2329A>G	c.(2329-2331)AAG>GAG	p.K777E	MYO1B_uc002usq.2_Missense_Mutation_p.K777E|MYO1B_uc002usr.2_Missense_Mutation_p.K777E|MYO1B_uc002usu.2_Missense_Mutation_p.K51E|MYO1B_uc002usv.2_5'Flank	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	777	IQ 3.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GAAGCATCAAAAGCGCTGTAA	0.473													G	192265141	G	G	192265141	3	3	76	1	0	0	0	0	1	0	0	0	10069	15	1	4	2411	4	MYO1B	2	192265141	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	13849072	192265141	50934232	15	5074											
DNAH7	56171	broad.mit.edu	37	chr2	196852773	196852773	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actatgattttctgcgaggaAgttatcaacatctcgctcag	8	9	4	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr2:196852773A>G	uc002utj.3	-	13	1635	c.1534T>C	c.(1534-1536)TTC>CTC	p.F512L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	512	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCTGCGAGGAAGTTATCAACA	0.338													G	196852773	G	G	196852773	3	3	76	1	0	0	0	0	1	0	0	0	4606	72	3	4	10752	4	DNAH7	2	196852773	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	4587632	196852773	46346600	16	5075											
CXCR1	3577	broad.mit.edu	37	chr2	219029097	219029097	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcccggccgatgttgttgcGgcgctcacagctctcctgga	14	14	2	0	rs61755739		TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr2:219029097G>A	uc002vhc.2	-	2	957	c.838C>T	c.(838-840)CGC>TGC	p.R280C		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	280	Extracellular (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2						ATGTTGTTGCGGCGCTCACAG	0.572													A	219029097	A	A	219029097	3	1	76	1	0	0	0	0	1	0	0	0	4090	1116	39	2	218	2	CXCR1	2	219029097	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	22176324	219029097	24170276	17	5076											
TRIP12	9320	broad.mit.edu	37	chr2	230724206	230724206	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtctttcttaggcacctgCcccgttttttgtctttctga	7	11	4	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr2:230724206C>T	uc002vpw.1	-	3	292	c.183G>A	c.(181-183)GGG>GGA	p.G61G	TRIP12_uc002vpx.1_Silent_p.G103G|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Silent_p.G61G	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	61					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TAGGCACCTGCCCCGTTTTTT	0.453													T	230724206	T	T	230724206	2	4	76	1	0	0	0	0	0	0	0	1	16553	726	26	3		3	TRIP12	2	230724206	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08	11695109	230724206	12475167	18	5077											
RBMS3	27303	broad.mit.edu	37	chr3	30032579	30032579	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atttgcctccttagggtgttGttgctgatacctctccccag	9	12	1	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr3:30032579G>T	uc003cel.2	+	14	1416	c.1186G>T	c.(1186-1188)GTT>TTT	p.V396F	RBMS3_uc003cek.2_Missense_Mutation_p.V380F|RBMS3_uc010hfq.2_Missense_Mutation_p.V393F|RBMS3_uc003cem.2_Missense_Mutation_p.V378F|RBMS3_uc010hfr.2_Missense_Mutation_p.V380F	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	396						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				TTAGGGTGTTGTTGCTGATAC	0.493													T	30032579	T	T	30032579	3	4	76	1	0	0	0	0	1	0	0	0	13150	1377	48	5	1283	5	RBMS3	3	30032579	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08		30032579	167989851	19	5078											
CLASP2	23122	broad.mit.edu	37	chr3	33584995	33584995	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaccagttagctggtgatcGtggtgttggtcttgtcaaag	15	6	2	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr3:33584995G>A	uc003cfu.2	-	31	3688	c.3334C>T	c.(3334-3336)CGA>TGA	p.R1112*	CLASP2_uc003cfs.2_Nonsense_Mutation_p.R319*|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Nonsense_Mutation_p.R712*	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1121										ovary(3)|central_nervous_system(1)	4						GCTGGTGATCGTGGTGTTGGT	0.373													A	33584995	A	A	33584995	4	1	76	1	0	0	0	0	0	1	0	0	3455	1153	40	1	1218	1	CLASP2	3	33584995	Nonsense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	3552416	33584995	164437435	20	5079											
STAB1	23166	broad.mit.edu	37	chr3	52550236	52550236	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtgagctgggccgctacGggcccaactgcaccggaggt	16	12	0	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr3:52550236G>A	uc003dej.2	+	38	4200	c.4126G>A	c.(4126-4128)GGG>AGG	p.G1376R	STAB1_uc003dek.1_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1376	Laminin EGF-like 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGGCCGCTACGGGCCCAACTG	0.697													A	52550236	A	A	52550236	3	1	76	1	0	0	0	0	1	0	0	0	15236	1116	39	2	4276	2	STAB1	3	52550236	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	18965241	52550236	145472194	21	5080											
FAM116A	201627	broad.mit.edu	37	chr3	57646541	57646541	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttttccctggcactggggcAggccatcgatcaacatcatt	10	12	2	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr3:57646541A>G	uc003dja.2	-	7	716	c.645T>C	c.(643-645)CCT>CCC	p.P215P		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	215										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		GCACTGGGGCAGGCCATCGAT	0.303													G	57646541	G	G	57646541	2	3	76	1	0	0	0	0	0	0	0	1	5407	175	7	4		4	FAM116A	3	57646541	Silent	SNP	A	TCGA-06-2558-01A-01D-1494-08	5096305	57646541	140375889	22	5081											
C3orf67	200844	broad.mit.edu	37	chr3	58739528	58739528	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactttcacaggaatctggaCgctgctcagccggctgttga	11	11	3	1	rs139574013		TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr3:58739528C>T	uc003dkt.1	-	15	1956	c.1547G>A	c.(1546-1548)CGT>CAT	p.R516H	C3orf67_uc003dkr.1_RNA|C3orf67_uc003dks.1_Missense_Mutation_p.R457H	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		GGAATCTGGACGCTGCTCAGC	0.388													T	58739528	T	T	58739528	3	4	76	1	0	0	0	0	1	0	0	0	2241	536	19	1	152	1	C3orf67	3	58739528	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	1092987	58739528	139282902	23	5082											
PPP4R2	151987	broad.mit.edu	37	chr3	73114106	73114106	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggggcatgaggtaaaaagaCtcaggtttgacaaagaaggt	14	4	1	4			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr3:73114106C>T	uc003dph.1	+	8	812	c.742C>T	c.(742-744)CTC>TTC	p.L248F	PPP4R2_uc003dpi.1_Missense_Mutation_p.L191F	NM_174907	NP_777567	Q9NY27	PP4R2_HUMAN	protein phosphatase 4, regulatory subunit 2	248					mRNA processing|protein modification process|regulation of double-strand break repair via homologous recombination|RNA splicing	centrosome|nucleus|protein phosphatase 4 complex	protein binding, bridging|protein phosphatase type 4 regulator activity			lung(1)	1		Prostate(10;0.0187)|Lung SC(41;0.236)		Epithelial(33;1.76e-07)|BRCA - Breast invasive adenocarcinoma(55;9.42e-05)|LUSC - Lung squamous cell carcinoma(21;0.00211)|Lung(16;0.00643)|KIRC - Kidney renal clear cell carcinoma(39;0.0164)|Kidney(39;0.0193)|OV - Ovarian serous cystadenocarcinoma(275;0.031)		GGTAAAAAGACTCAGGTTTGA	0.433													T	73114106	T	T	73114106	3	4	76	1	0	0	0	0	1	0	0	0	12404	565	20	3	772	3	PPP4R2	3	73114106	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	14374578	73114106	124908324	24	5083											
ABCC5	10057	broad.mit.edu	37	chr3	183667646	183667646	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgcgtgatattgtccagaCgcttcagctcccgaatcagg	10	12	2	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr3:183667646C>T	uc003fmg.2	-	22	3287	c.3122G>A	c.(3121-3123)CGT>CAT	p.R1041H	ABCC5_uc011bqt.1_Missense_Mutation_p.R569H|ABCC5_uc010hxl.2_Intron	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1041	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATTGTCCAGACGCTTCAGCTC	0.562													T	183667646	T	T	183667646	3	4	76	1	0	0	0	0	1	0	0	0	56	536	19	1	1227	1	ABCC5	3	183667646	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	110553540	183667646	14354784	25	5084											
HTR3E	285242	broad.mit.edu	37	chr3	183824315	183824315	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgcggaggcagagctgacagGgggctcagaatggacaaggg	19	7	1	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr3:183824315G>T	uc010hxq.2	+	9	1671	c.1205G>T	c.(1204-1206)GGG>GTG	p.G402V	HTR3E_uc003fml.3_Missense_Mutation_p.G387V|HTR3E_uc003fmm.2_Missense_Mutation_p.G417V|HTR3E_uc010hxr.2_Missense_Mutation_p.G428V|HTR3E_uc003fmn.2_Missense_Mutation_p.G402V	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	402	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GAGCTGACAGGGGGCTCAGAA	0.612													T	183824315	T	T	183824315	3	4	76	1	0	0	0	0	1	0	0	0	7448	1232	43	5	1280	5	HTR3E	3	183824315	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	156669	183824315	14198115	26	5085											
RGS12	6002	broad.mit.edu	37	chr4	3427237	3427237	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggcgcccctatatcgagtcTggacggacagcgggttgtct	14	11	2	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr4:3427237T>G	uc003ggw.2	+	14	4185	c.3281T>G	c.(3280-3282)CTG>CGG	p.L1094R	RGS12_uc003ggv.2_Missense_Mutation_p.L1094R|RGS12_uc003ggy.1_Missense_Mutation_p.L492R|RGS12_uc003ggz.2_Missense_Mutation_p.L446R|RGS12_uc010icu.1_Missense_Mutation_p.L293R|RGS12_uc011bvs.1_Missense_Mutation_p.L436R|RGS12_uc003gha.2_Missense_Mutation_p.L436R|RGS12_uc010icv.2_Missense_Mutation_p.L293R|RGS12_uc003ghb.2_Missense_Mutation_p.L293R	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1094	RBD 2.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ATATCGAGTCTGGACGGACAG	0.572													G	3427237	G	G	3427237	3	3	76	1	0	0	0	0	1	0	0	0	13295	1580	55	5	3389	5	RGS12	4	3427237	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08		3427237	187727039	27	5086											
CLNK	116449	broad.mit.edu	37	chr4	10567771	10567771	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caggactgcagcaaagtttcTttcctaagcaggtggtaaca	10	9	1	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr4:10567771T>C	uc003gmo.3	-	6	291	c.154A>G	c.(154-156)AGA>GGA	p.R52G	CLNK_uc003gmp.2_Missense_Mutation_p.R10G	NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	52					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						GCAAAGTTTCTTTCCTAAGCA	0.458													C	10567771	C	C	10567771	3	2	76	1	0	0	0	0	1	0	0	0	3547	1617	56	4	1188	4	CLNK	4	10567771	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08	7140534	10567771	180586505	28	5087											
CORIN	10699	broad.mit.edu	37	chr4	47625643	47625643	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttggcaatgaggacacagcCacagatatgtccactgggtt	11	10	0	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr4:47625643C>A	uc003gxm.2	-	19	2578	c.2485G>T	c.(2485-2487)GGC>TGC	p.G829C	CORIN_uc011bzf.1_Missense_Mutation_p.G690C|CORIN_uc011bzg.1_Missense_Mutation_p.G762C	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	829	Extracellular (Potential).|Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity	p.G829G(1)		ovary(1)|central_nervous_system(1)	2						AGGACACAGCCACAGATATGT	0.527													A	47625643	A	A	47625643	3	1	76	1	0	0	0	0	1	0	0	0	3752	594	21	5	659	5	CORIN	4	47625643	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	37057872	47625643	143528633	29	5088											
PDHA2	5161	broad.mit.edu	37	chr4	96761557	96761557	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtacaaacagaaattcattCgcggtttctgtcacctgtgc	8	10	3	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr4:96761557C>T	uc003htr.3	+	1	319	c.256C>T	c.(256-258)CGC>TGC	p.R86C		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	86					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GAAATTCATTCGCGGTTTCTG	0.517													T	96761557	T	T	96761557	3	4	76	1	0	0	0	0	1	0	0	0	11665	884	31	2	258	2	PDHA2	4	96761557	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	49135914	96761557	94392719	30	5089											
ENPEP	2028	broad.mit.edu	37	chr4	111464226	111464226	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgatgcttttgccttggcaaGgtgcgttttagaatgagact	12	6	0	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr4:111464226G>T	uc003iab.3	+	13	2342	c.2000G>T	c.(1999-2001)AGA>ATA	p.R667I		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	667	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GCCTTGGCAAGGTGCGTTTTA	0.328													T	111464226	T	T	111464226	3	4	76	1	0	0	0	0	1	0	0	0	5128	1014	35	5	2050	5	ENPEP	4	111464226	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	14702669	111464226	79690050	31	5090											
BRIX1	55299	broad.mit.edu	37	chr5	34924991	34924991	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctcttgtagaaataggacctCgttttgtcttaaatctcata	6	8	3	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr5:34924991C>G	uc003jja.2	+	9	727	c.703C>G	c.(703-705)CGT>GGT	p.R235G		NM_018321	NP_060791	Q8TDN6	BRX1_HUMAN	BRIX	235	Brix.				ribosome biogenesis|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|protein binding				0						AATAGGACCTCGTTTTGTCTT	0.358													G	34924991	G	G	34924991	3	3	76	1	0	0	0	0	1	0	0	0	1515	884	31	5	737	5	BRIX1	5	34924991	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08		34924991	145990269	32	5091											
CHSY3	337876	broad.mit.edu	37	chr5	129244015	129244015	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggaagtaggaagatgcgttCgccgttttggtgggactcag	16	6	1	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr5:129244015C>T	uc003kvd.2	+	2	1048	c.1048C>T	c.(1048-1050)CGC>TGC	p.R350C		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	350	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		AAGATGCGTTCGCCGTTTTGG	0.438													T	129244015	T	T	129244015	3	4	76	1	0	0	0	0	1	0	0	0	3413	884	31	2	1054	2	CHSY3	5	129244015	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	94319024	129244015	51671245	33	5092											
CSNK1A1	1452	broad.mit.edu	37	chr5	148929730	148929730	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggccttctgagattctagCttcactgccacttcctgcag	8	14	3	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr5:148929730C>T	uc003lqx.1	-	2	618	c.138G>A	c.(136-138)AAG>AAA	p.K46K	CSNK1A1_uc011dcc.1_5'UTR|CSNK1A1_uc003lqv.1_5'UTR|CSNK1A1_uc003lqw.1_Silent_p.K46K|CSNK1A1_uc003lqy.1_Silent_p.K46K|CSNK1A1_uc010jha.1_Silent_p.K46K	NM_001892	NP_001883	P48729	KC1A_HUMAN	casein kinase 1, alpha 1 isoform 2	46	Protein kinase.	ATP (By similarity).			cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein binding|protein serine/threonine kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GAGATTCTAGCTTCACTGCCA	0.502													T	148929730	T	T	148929730	2	4	76	1	0	0	0	0	0	0	0	1	3950	796	28	3		3	CSNK1A1	5	148929730	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08	19685715	148929730	31985530	34	5093											
DSP	1832	broad.mit.edu	37	chr6	7569463	7569463	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtatcctgaaggacaacaaCgagcgcagcaagtggtacgt	12	9	0	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr6:7569463C>T	uc003mxp.1	+	12	1743	c.1464C>T	c.(1462-1464)AAC>AAT	p.N488N	DSP_uc003mxq.1_Silent_p.N488N	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	488	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGACAACAACGAGCGCAGCA	0.527													T	7569463	T	T	7569463	2	4	76	1	0	0	0	0	0	0	0	1	4781	535	19	1		1	DSP	6	7569463	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08		7569463	163545604	35	5094											
SRPK1	6732	broad.mit.edu	37	chr6	35855829	35855829	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcaaccggatttcatctagtGctgtttcagtgtaatgttca	9	8	4	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr6:35855829G>C	uc003olj.2	-	5	485	c.362C>G	c.(361-363)GCA>GGA	p.A121G	SRPK1_uc011dtg.1_Missense_Mutation_p.A105G|SRPK1_uc003olh.2_Missense_Mutation_p.A14G|SRPK1_uc003oli.2_Missense_Mutation_p.A14G	NM_003137	NP_003128	Q96SB4	SRPK1_HUMAN	SFRS protein kinase 1	121	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						TTCATCTAGTGCTGTTTCAGT	0.338													C	35855829	C	C	35855829	3	2	76	1	0	0	0	0	1	0	0	0	15158	1319	46	5	1653	5	SRPK1	6	35855829	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	28286366	35855829	135259238	36	5095											
CDKN1A	1026	broad.mit.edu	37	chr6	36652137	36652137	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cggggccccggcgaggccggGatgagttgggaggaggcagg	23	9	0	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr6:36652137G>A	uc003omm.3	+	2	381	c.259G>A	c.(259-261)GAT>AAT	p.D87N	CDKN1A_uc011dtq.1_Missense_Mutation_p.D121N|CDKN1A_uc003oml.2_Missense_Mutation_p.D87N|CDKN1A_uc003omn.2_Missense_Mutation_p.D87N	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	87					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GCGAGGCCGGGATGAGTTGGG	0.657									Multiple_Endocrine_Neoplasia_type_1				A	36652137	A	A	36652137	3	1	76	1	0	0	0	0	1	0	0	0	3158	1174	41	3	261	3	CDKN1A	6	36652137	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	796308	36652137	134462930	37	5096											
PKHD1	5314	broad.mit.edu	37	chr6	51910848	51910848	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tctgagtggaccaggacaagGtccacacgtgttcgtagcaa	12	10	1	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr6:51910848G>T	uc003pah.1	-	24	2822	c.2546C>A	c.(2545-2547)ACC>AAC	p.T849N	PKHD1_uc003pai.2_Missense_Mutation_p.T849N	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	849	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCAGGACAAGGTCCACACGTG	0.463													T	51910848	T	T	51910848	3	4	76	1	0	0	0	0	1	0	0	0	11971	1261	44	5	9893	5	PKHD1	6	51910848	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	15258711	51910848	119204219	38	5097											
HCRTR2	3062	broad.mit.edu	37	chr6	55113582	55113582	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actgagacctggttttttggAcagtccctttgcaaagtgat	10	8	0	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr6:55113582A>G	uc003pcl.2	+	2	684	c.369A>G	c.(367-369)GGA>GGG	p.G123G	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Silent_p.G58G	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	123	Extracellular (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GGTTTTTTGGACAGTCCCTTT	0.428													G	55113582	G	G	55113582	2	3	76	1	0	0	0	0	0	0	0	1	7002	262	10	4		4	HCRTR2	6	55113582	Silent	SNP	A	TCGA-06-2558-01A-01D-1494-08	3202734	55113582	116001485	39	5098											
SYNE1	23345	broad.mit.edu	37	chr6	152652051	152652051	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagaactctcattcattaggTtgatttcaggaaatgtaaca	7	7	3	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr6:152652051T>C	uc010kiw.2	-	78	14371	c.13769A>G	c.(13768-13770)AAC>AGC	p.N4590S	SYNE1_uc003qot.3_Missense_Mutation_p.N4519S|SYNE1_uc003qou.3_Missense_Mutation_p.N4590S|SYNE1_uc010kiz.2_Missense_Mutation_p.N345S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4590	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATTCATTAGGTTGATTTCAGG	0.353										HNSCC(10;0.0054)			C	152652051	C	C	152652051	3	2	76	1	0	0	0	0	1	0	0	0	15442	1725	60	4	12973	4	SYNE1	6	152652051	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08	97538469	152652051	18463016	40	5099											
ADCYAP1R1	117	broad.mit.edu	37	chr7	31126052	31126052	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	actgtgttgtgtccaactacTtctggctgttcatcgagggc	11	10	2	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr7:31126052T>A	uc003tca.1	+	10	947	c.724T>A	c.(724-726)TTC>ATC	p.F242I	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.F221I|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.F242I|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.F242I|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.F242I|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	242	Helical; Name=3; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						GTCCAACTACTTCTGGCTGTT	0.542													A	31126052	A	A	31126052	3	1	76	1	0	0	0	0	1	0	0	0	303	1609	56	5	758	5	ADCYAP1R1	7	31126052	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08		31126052	128012611	41	5100											
HECW1	23072	broad.mit.edu	37	chr7	43485123	43485123	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcacgtggaaagaagcccGgaaggtctggaatcccccgt	15	11	1	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr7:43485123G>A	uc003tid.1	+	11	2957	c.2352G>A	c.(2350-2352)CCG>CCA	p.P784P	HECW1_uc011kbi.1_Silent_p.P784P	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	784					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.L784I(1)		ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AAAGAAGCCCGGAAGGTCTGG	0.612													A	43485123	A	A	43485123	2	1	76	1	0	0	0	0	0	0	0	1	7042	1103	39	2		2	HECW1	7	43485123	Silent	SNP	G	TCGA-06-2558-01A-01D-1494-08	12359071	43485123	115653540	42	5101											
GNAT3	346562	broad.mit.edu	37	chr7	80091827	80091827	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttagacttaccacttcttcGtcttccacgaggaccatgtc	6	13	2	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr7:80091827G>A	uc011kgu.1	-	6	711	c.711C>T	c.(709-711)GAC>GAT	p.D237D	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	237					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						CCACTTCTTCGTCTTCCACGA	0.408													A	80091827	A	A	80091827	2	1	76	1	0	0	0	0	0	0	0	1	6513	1136	40	1		1	GNAT3	7	80091827	Silent	SNP	G	TCGA-06-2558-01A-01D-1494-08	36606704	80091827	79046836	43	5102											
SEMA3C	10512	broad.mit.edu	37	chr7	80378254	80378254	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctttctgtaacagccacttgAtagatgcctgcggagacttg	10	10	1	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr7:80378254A>G	uc003uhj.2	-	17	2364	c.1802T>C	c.(1801-1803)ATC>ACC	p.I601T	SEMA3C_uc011kgw.1_Missense_Mutation_p.I619T	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	601	Ig-like C2-type.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						CAGCCACTTGATAGATGCCTG	0.453													G	80378254	G	G	80378254	3	3	76	1	0	0	0	0	1	0	0	0	14026	333	12	4	461	4	SEMA3C	7	80378254	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	286427	80378254	78760409	44	5103											
CACNA2D1	781	broad.mit.edu	37	chr7	81635118	81635118	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gtcttttaatatcttccaaaGacacatctactcccatcaca	2	13	4	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr7:81635118G>C	uc003uhr.1	-	17	1734	c.1478C>G	c.(1477-1479)TCT>TGT	p.S493C		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	493	Extracellular (Potential).|Cache.					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATCTTCCAAAGACACATCTAC	0.328													C	81635118	C	C	81635118	3	2	76	1	0	0	0	0	1	0	0	0	2548	942	33	5	1889	5	CACNA2D1	7	81635118	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	1256864	81635118	77503545	45	5104											
KEL	3792	broad.mit.edu	37	chr7	142658027	142658027	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttcctcacccagtattctccGaagtcggtttttgttctttg	7	11	3	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr7:142658027G>A	uc003wcb.2	-	4	598	c.388C>T	c.(388-390)CGG>TGG	p.R130W		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	130	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					AGTATTCTCCGAAGTCGGTTT	0.502													A	142658027	A	A	142658027	3	1	76	1	0	0	0	0	1	0	0	0	8142	1057	37	2	1874	2	KEL	7	142658027	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	61022909	142658027	16480636	46	5105											
ARHGEF10	9639	broad.mit.edu	37	chr8	1871955	1871955	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcagatctgggcgaccgacGttctttacagctgtgttcaa	12	10	3	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr8:1871955G>A	uc003wpr.2	+	21	2581	c.2403G>A	c.(2401-2403)ACG>ACA	p.T801T	ARHGEF10_uc003wpq.1_Silent_p.T825T|ARHGEF10_uc003wps.2_Silent_p.T763T|ARHGEF10_uc003wpv.2_Silent_p.T534T|ARHGEF10_uc010lre.2_Silent_p.T481T	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	826					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		GGCGACCGACGTTCTTTACAG	0.488													A	1871955	A	A	1871955	2	1	76	1	0	0	0	0	0	0	0	1	894	1132	40	1		1	ARHGEF10	8	1871955	Silent	SNP	G	TCGA-06-2558-01A-01D-1494-08		1871955	144492067	47	5106											
WRN	7486	broad.mit.edu	37	chr8	30977768	30977768	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttgttctcagtgtgtcataGctaccatagcttttggaatg	9	7	2	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr8:30977768G>C	uc003xio.3	+	21	3246	c.2458G>C	c.(2458-2460)GCT>CCT	p.A820P	WRN_uc010lvk.2_Missense_Mutation_p.A287P	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	820	Helicase C-terminal.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		GTGTGTCATAGCTACCATAGC	0.353			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				C	30977768	C	C	30977768	3	2	76	1	0	0	0	0	1	0	0	0	17399	971	34	5	2536	5	WRN	8	30977768	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	29105813	30977768	115386254	48	5107											
SDC2	6383	broad.mit.edu	37	chr8	97614730	97614730	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaaccacgacgctgaatataCagaacaagatacctgctcag	7	11	1	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr8:97614730C>G	uc003yhv.1	+	3	898	c.280C>G	c.(280-282)CAG>GAG	p.Q94E	SDC2_uc011lgu.1_Missense_Mutation_p.Q65E	NM_002998	NP_002989	P34741	SDC2_HUMAN	syndecan 2 precursor	94	Extracellular (Potential).					integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			ovary(2)	2	Breast(36;3.41e-05)				Sargramostim(DB00020)	GCTGAATATACAGAACAAGAT	0.423													G	97614730	G	G	97614730	3	3	76	1	0	0	0	0	1	0	0	0	13952	479	17	5	290	5	SDC2	8	97614730	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	66636962	97614730	48749292	49	5108											
RGS22	26166	broad.mit.edu	37	chr8	101059740	101059740	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctggatacaaaagctcccGcttccaaggcttttgagttg	9	11	0	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr8:101059740G>A	uc003yjb.1	-	11	1969	c.1774C>T	c.(1774-1776)CGG>TGG	p.R592W	RGS22_uc003yja.1_Missense_Mutation_p.R411W|RGS22_uc003yjc.1_Missense_Mutation_p.R580W|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	592					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AAAAGCTCCCGCTTCCAAGGC	0.383													A	101059740	A	A	101059740	3	1	76	1	0	0	0	0	1	0	0	0	13305	1086	38	1	2088	1	RGS22	8	101059740	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	3445010	101059740	45304282	50	5109											
FAM83A	84985	broad.mit.edu	37	chr8	124206323	124206323	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gccaagtcaggcaggaaattCgctggccaaatccgggagaa	13	10	1	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr8:124206323C>T	uc003ypv.2	+	4	2722	c.708C>T	c.(706-708)TTC>TTT	p.F236F	FAM83A_uc003ypw.2_Silent_p.F236F|FAM83A_uc003ypy.2_Silent_p.F180F|FAM83A_uc003ypx.2_Silent_p.F236F|FAM83A_uc003ypz.2_Silent_p.F236F	NM_032899	NP_116288	Q86UY5	FA83A_HUMAN	hypothetical protein LOC84985 isoform a	236										ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GCAGGAAATTCGCTGGCCAAA	0.473													T	124206323	T	T	124206323	2	4	76	1	0	0	0	0	0	0	0	1	5633	883	31	2		2	FAM83A	8	124206323	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08	23146583	124206323	22157699	51	5110											
ZNF322B	387328	broad.mit.edu	37	chr9	99961445	99961445	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgcatgtgttctctgatGtcctgaaagcactaagtgat	9	9	1	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr9:99961445G>A	uc004axd.1	-	1	466	c.349C>T	c.(349-351)CAT>TAT	p.H117Y	uc004axb.2_5'Flank|ZNF322B_uc004axc.1_5'Flank|uc010msl.1_Intron	NM_199005	NP_945356			zinc finger protein 322B												0		Acute lymphoblastic leukemia(62;0.158)				GTTCTCTGATGTCCTGAAAGC	0.408													A	99961445	A	A	99961445	3	1	76	1	0	0	0	0	1	0	0	0	17839	1377	48	3	863	3	ZNF322B	9	99961445	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08		99961445	41251986	52	5111											
OR13C8	138802	broad.mit.edu	37	chr9	107332231	107332231	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcttcttcatgtacgcaaaGcctgagtctaaagcctctgt	7	11	5	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr9:107332231G>A	uc011lvo.1	+	1	783	c.783G>A	c.(781-783)AAG>AAA	p.K261K		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGTACGCAAAGCCTGAGTCTA	0.453													A	107332231	A	A	107332231	2	1	76	1	0	0	0	0	0	0	0	1	10938	962	34	3		3	OR13C8	9	107332231	Silent	SNP	G	TCGA-06-2558-01A-01D-1494-08	7370786	107332231	33881200	53	5112											
CUBN	8029	broad.mit.edu	37	chr10	17083094	17083094	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaatgctaaaaatgtgtagtTcacagtgttgcctgttgttg	10	5	1	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr10:17083094T>C	uc001ioo.2	-	27	4007	c.3955A>G	c.(3955-3957)AAC>GAC	p.N1319D		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1319	CUB 8.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AATGTGTAGTTCACAGTGTTG	0.383													C	17083094	C	C	17083094	3	2	76	1	0	0	0	0	1	0	0	0	4051	1783	62	4	7080	4	CUBN	10	17083094	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08		17083094	118451653	54	5113											
A1CF	29974	broad.mit.edu	37	chr10	52587910	52587910	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cctggtttgatattgttgaaTtccttttcaatcatctcttc	5	9	3	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr10:52587910T>A	uc001jjj.2	-	7	938	c.750A>T	c.(748-750)GAA>GAT	p.E250D	A1CF_uc010qhn.1_Missense_Mutation_p.E258D|A1CF_uc001jji.2_Missense_Mutation_p.E250D|A1CF_uc001jjh.2_Missense_Mutation_p.E258D|A1CF_uc010qho.1_Missense_Mutation_p.E258D|A1CF_uc009xov.2_Missense_Mutation_p.E250D	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	250	RRM 3.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						TATTGTTGAATTCCTTTTCAA	0.234													A	52587910	A	A	52587910	3	1	76	1	0	0	0	0	1	0	0	0	2	1490	52	5	1062	5	A1CF	10	52587910	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08	35504816	52587910	82946837	55	5114											
PTEN	5728	broad.mit.edu	37	chr10	89692904	89692904	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgtaaagctggaaagggaCgaactggtgtaatgatatgt	13	4	0	1	rs121909224		TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr10:89692904C>T	uc001kfb.2	+	6	1419	c.388C>T	c.(388-390)CGA>TGA	p.R130*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).	R->M: Does not affect the ability to inhibit AKT/PKB activation.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130G(65)|p.R130*(61)|p.R130Q(43)|p.R130fs*4(12)|p.R130L(7)|p.R130P(4)|p.R55fs*1(4)|p.K128_R130del(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.K128fs*47(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.R130R(1)|p.F56fs*2(1)|p.G129fs*50(1)|p.G129fs*51(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGGAAAGGGACGAACTGGTGT	0.403	R130G(OV56_OVARY)|R130G(KMBC2_URINARY_TRACT)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89692904	T	T	89692904	4	4	76	1	0	0	0	0	0	1	0	0	12738	528	19	1	406	1	PTEN	10	89692904	Nonsense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	37104994	89692904	45841843	56	5115											
OR51G1	79324	broad.mit.edu	37	chr11	4945014	4945014	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agagcaggccagcttcatgaTctccaggtgaagacaataag	11	9	2	4			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr11:4945014T>A	uc010qyr.1	-	1	556	c.556A>T	c.(556-558)ATC>TTC	p.I186F		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCTTCATGATCTCCAGGTGA	0.522													A	4945014	A	A	4945014	3	1	76	1	0	0	0	0	1	0	0	0	11098	1435	50	5	411	5	OR51G1	11	4945014	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08		4945014	130061502	57	5116											
FADS3	3995	broad.mit.edu	37	chr11	61646097	61646097	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcggaagttccaccagtgggCggagaagccctgtggaggag	18	9	0	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr11:61646097C>G	uc001nsm.2	-	5	787	c.634G>C	c.(634-636)GCC>CCC	p.A212P	FADS3_uc001nsn.2_Missense_Mutation_p.A88P	NM_021727	NP_068373	Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	212	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			ovary(1)|pancreas(1)	2						CACCAGTGGGCGGAGAAGCCC	0.667													G	61646097	G	G	61646097	3	3	76	1	0	0	0	0	1	0	0	0	5367	768	27	5	735	5	FADS3	11	61646097	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	56701083	61646097	73360419	58	5117											
DNAJC4	3338	broad.mit.edu	37	chr11	64001432	64001432	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcatcacagccttctacaaCgaagcccgggcacgggccag	10	15	3	0	rs138996784	by1000genomes	TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr11:64001432C>T	uc001nys.2	+	6	1056	c.594C>T	c.(592-594)AAC>AAT	p.N198N	uc001nyr.1_5'Flank|DNAJC4_uc001nyt.2_Silent_p.N199N|DNAJC4_uc001nyu.2_Silent_p.N198N|VEGFB_uc001nyw.2_5'Flank|VEGFB_uc001nyx.2_5'Flank	NM_005528	NP_005519	Q9NNZ3	DNJC4_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 4	198					protein folding|response to unfolded protein	integral to membrane|membrane fraction	heat shock protein binding|unfolded protein binding				0						CCTTCTACAACGAAGCCCGGG	0.547													T	64001432	T	T	64001432	2	4	76	1	0	0	0	0	0	0	0	1	4649	535	19	1		1	DNAJC4	11	64001432	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08	2355335	64001432	71005084	59	5118											
FAT3	120114	broad.mit.edu	37	chr11	92533806	92533806	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcaatgactttgccaaggatCgattcctcatagacagcaat	7	10	2	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr11:92533806C>T	uc001pdj.3	+	9	7644	c.7627C>T	c.(7627-7629)CGA>TGA	p.R2543*		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2543	Cadherin 23.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGCCAAGGATCGATTCCTCAT	0.488										TCGA Ovarian(4;0.039)			T	92533806	T	T	92533806	4	4	76	1	0	0	0	0	0	1	0	0	5691	876	31	2	7661	2	FAT3	11	92533806	Nonsense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	28532374	92533806	42472710	60	5119											
CNTN5	53942	broad.mit.edu	37	chr11	99690432	99690432	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcttcacccagctggctaggGgcagctcagaattattattc	9	11	3	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr11:99690432G>T	uc001pga.2	+	4	552	c.213G>T	c.(211-213)GGG>GGT	p.G71G	CNTN5_uc009ywv.1_Silent_p.G71G|CNTN5_uc001pfz.2_Silent_p.G71G|CNTN5_uc001pgb.2_Intron	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	71					cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GCTGGCTAGGGGCAGCTCAGA	0.378													T	99690432	T	T	99690432	2	4	76	1	0	0	0	0	0	0	0	1	3644	1219	43	5		5	CNTN5	11	99690432	Silent	SNP	G	TCGA-06-2558-01A-01D-1494-08	7156626	99690432	35316084	61	5120											
CLDN25	644672	broad.mit.edu	37	chr11	113650596	113650596	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgggtctgctcctgtgttAccaccatcctgccccagtgg	11	15	1	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr11:113650596A>G	uc009yyw.1	+	1	79	c.79A>G	c.(79-81)ACC>GCC	p.T27A		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	27	Helical; (Potential).					integral to membrane|tight junction	structural molecule activity				0						CTCCTGTGTTACCACCATCCT	0.557													G	113650596	G	G	113650596	3	3	76	1	0	0	0	0	1	0	0	0	3485	391	14	4	81	4	CLDN25	11	113650596	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	13960164	113650596	21355920	62	5121											
ACSM4	341392	broad.mit.edu	37	chr12	7476137	7476137	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caaacctacacggcccttctGtttcttctctaaatatgtgg	6	12	3	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr12:7476137G>C	uc001qsx.1	+	9	1289	c.1289G>C	c.(1288-1290)TGT>TCT	p.C430S		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	430					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						CGGCCCTTCTGTTTCTTCTCT	0.229													C	7476137	C	C	7476137	3	2	76	1	0	0	0	0	1	0	0	0	186	1377	48	5	1323	5	ACSM4	12	7476137	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08		7476137	126375758	63	5122											
CD163	9332	broad.mit.edu	37	chr12	7636017	7636017	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acactcactatggccccagcGtctggcaggacaatcccaca	8	16	2	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr12:7636017G>A	uc001qsz.3	-	12	3162	c.3034C>T	c.(3034-3036)CGC>TGC	p.R1012C	CD163_uc001qta.3_Missense_Mutation_p.R1012C|CD163_uc009zfw.2_Missense_Mutation_p.R1045C	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1012	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TGGCCCCAGCGTCTGGCAGGA	0.512													A	7636017	A	A	7636017	3	1	76	1	0	0	0	0	1	0	0	0	2967	1145	40	1	456	1	CD163	12	7636017	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	159880	7636017	126215878	64	5123											
KIAA1467	57613	broad.mit.edu	37	chr12	13208635	13208635	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcgccagaacccgactcagAtgctgaggttgcagaggctg	14	11	1	4			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr12:13208635A>G	uc001rbi.2	+	2	211	c.188A>G	c.(187-189)GAT>GGT	p.D63G	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	63						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		CCCGACTCAGATGCTGAGGTT	0.562													G	13208635	G	G	13208635	3	3	76	1	0	0	0	0	1	0	0	0	8235	333	12	4	194	4	KIAA1467	12	13208635	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	5572618	13208635	120643260	65	5124											
PTPRB	5787	broad.mit.edu	37	chr12	70949924	70949924	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggttttgtatcttgtcAggctctaaaggaaacagagg	12	6	3	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr12:70949924A>G	uc001swb.3	-	17	4095	c.4065T>C	c.(4063-4065)CCT>CCC	p.P1355P	PTPRB_uc010sto.1_Silent_p.P1265P|PTPRB_uc010stp.1_Silent_p.P1265P|PTPRB_uc001swc.3_Silent_p.P1573P|PTPRB_uc001swa.3_Silent_p.P1485P	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1355	Fibronectin type-III 16.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTATCTTGTCAGGCTCTAAAG	0.438													G	70949924	G	G	70949924	2	3	76	1	0	0	0	0	0	0	0	1	12796	175	7	4		4	PTPRB	12	70949924	Silent	SNP	A	TCGA-06-2558-01A-01D-1494-08	57741289	70949924	62901971	66	5125											
FSCB	84075	broad.mit.edu	37	chr14	44974610	44974610	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggagcctctatagctgctagAagctgaatttcagcagaggc	12	9	2	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr14:44974610A>T	uc001wvn.2	-	1	1890	c.1581T>A	c.(1579-1581)CTT>CTA	p.L527L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	527	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		TAGCTGCTAGAAGCTGAATTT	0.493													T	44974610	T	T	44974610	2	4	76	1	0	0	0	0	0	0	0	1	6066	233	9	5		5	FSCB	14	44974610	Silent	SNP	A	TCGA-06-2558-01A-01D-1494-08		44974610	62374930	67	5126											
SYT16	83851	broad.mit.edu	37	chr14	62536340	62536340	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcaacagctttggggatgaCgaagagctgtccacatcttc	11	10	2	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr14:62536340C>T	uc001xfu.1	+	2	740	c.543C>T	c.(541-543)GAC>GAT	p.D181D	SYT16_uc010tsd.1_Silent_p.D181D	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	181										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TTGGGGATGACGAAGAGCTGT	0.483													T	62536340	T	T	62536340	2	4	76	1	0	0	0	0	0	0	0	1	15469	535	19	1		1	SYT16	14	62536340	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08	17561730	62536340	44813200	68	5127											
SERPINA5	5104	broad.mit.edu	37	chr14	95054156	95054156	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taagtgccatgaagacgctgTacctggcagacactttccct	9	12	0	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr14:95054156T>C	uc001ydm.2	+	3	667	c.457T>C	c.(457-459)TAC>CAC	p.Y153H	SERPINA5_uc010ave.2_Missense_Mutation_p.Y153H|SERPINA5_uc001ydn.1_Missense_Mutation_p.Y153H	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	153					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GAAGACGCTGTACCTGGCAGA	0.537													C	95054156	C	C	95054156	3	2	76	1	0	0	0	0	1	0	0	0	14092	1638	57	4	459	4	SERPINA5	14	95054156	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08	32517816	95054156	12295384	69	5128											
WDR72	256764	broad.mit.edu	37	chr15	53994476	53994476	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tccaactttggtctaatttcGaagagagaccatgtggatag	10	7	1	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr15:53994476G>A	uc002acj.2	-	12	1466	c.1424C>T	c.(1423-1425)TCG>TTG	p.S475L	WDR72_uc010bfi.1_Missense_Mutation_p.S475L	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	475	WD 6.									lung(1)|skin(1)	2				all cancers(107;0.0511)		GTCTAATTTCGAAGAGAGACC	0.383													A	53994476	A	A	53994476	3	1	76	1	0	0	0	0	1	0	0	0	17319	1059	37	2	1920	2	WDR72	15	53994476	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08		53994476	48536916	70	5129											
HERC1	8925	broad.mit.edu	37	chr15	63948072	63948072	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgttctcttcagcaattcctCggagaaagctgggtagaaac	10	9	2	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr15:63948072C>T	uc002amp.2	-	50	10101	c.9953G>A	c.(9952-9954)CGA>CAA	p.R3318Q		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3318					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						AGCAATTCCTCGGAGAAAGCT	0.448													T	63948072	T	T	63948072	3	4	76	1	0	0	0	0	1	0	0	0	7057	884	31	2	4748	2	HERC1	15	63948072	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	9953596	63948072	38583320	71	5130											
ACSM2B	348158	broad.mit.edu	37	chr16	20548638	20548638	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtctcgaagtttggttcgtTgaattttccctgtgacagtc	10	8	1	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr16:20548638T>C	uc002dhj.3	-	15	1886	c.1676A>G	c.(1675-1677)CAA>CGA	p.Q559R	ACSM2B_uc002dhk.3_Missense_Mutation_p.Q559R	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	559					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TTTGGTTCGTTGAATTTTCCC	0.483													C	20548638	C	C	20548638	3	2	76	1	0	0	0	0	1	0	0	0	184	1812	63	4	61	4	ACSM2B	16	20548638	Missense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08		20548638	69806115	72	5131											
IL21R	50615	broad.mit.edu	37	chr16	27441407	27441407	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcagcatgccgcgtggctgGgccgcccccttgctcctgct	13	17	1	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr16:27441407G>A	uc002doq.1	+	2	248	c.15G>A	c.(13-15)TGG>TGA	p.W5*	IL21R_uc002dor.1_Nonsense_Mutation_p.W5*|IL21R_uc002dos.1_Nonsense_Mutation_p.W5*	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	5					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						CGCGTGGCTGGGCCGCCCCCT	0.716			T	BCL6	NHL								A	27441407	A	A	27441407	4	1	76	1	0	0	0	0	0	1	0	0	7671	1241	43	3	17	3	IL21R	16	27441407	Nonsense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	6892769	27441407	62913346	73	5132											
RILP	83547	broad.mit.edu	37	chr17	1551765	1551765	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgccctgcctccgaggggcGcccgagctgctgcgcggcct	15	18	0	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr17:1551765G>T	uc002ftd.2	-	5	994	c.700C>A	c.(700-702)CGC>AGC	p.R234S	SCARF1_uc002fsy.1_5'Flank|SCARF1_uc002fsz.1_5'Flank|SCARF1_uc002fta.1_5'Flank|SCARF1_uc010cjv.1_5'Flank	NM_031430	NP_113618	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	234					endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TCCGAGGGGCGCCCGAGCTGC	0.637													T	1551765	T	T	1551765	3	4	76	1	0	0	0	0	1	0	0	0	13360	1087	38	5	521	5	RILP	17	1551765	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08		1551765	79643445	74	5133											
TP53	7157	broad.mit.edu	37	chr17	7577097	7577097	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctcttcctctgtgcgccggtCtctcccaggacaggcacaaa	9	16	3	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr17:7577097C>G	uc002gim.2	-	8	1035	c.841G>C	c.(841-843)GAC>CAC	p.D281H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.D281H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.D149H|TP53_uc010cng.1_Missense_Mutation_p.D149H|TP53_uc002gii.1_Missense_Mutation_p.D149H|TP53_uc010cnh.1_Missense_Mutation_p.D281H|TP53_uc010cni.1_Missense_Mutation_p.D281H|TP53_uc002gij.2_Missense_Mutation_p.D281H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	281	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		D -> Y (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> V (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|D -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|D -> G (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|D -> A (in sporadic cancers; somatic mutation).|D -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.D281E(25)|p.D281H(19)|p.D281N(18)|p.D281G(10)|p.0?(7)|p.D281Y(6)|p.D281D(5)|p.D281V(3)|p.D281fs*63(2)|p.?(2)|p.R280_D281delRD(2)|p.D281A(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.D281R(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGCGCCGGTCTCTCCCAGGA	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			G	7577097	G	G	7577097	3	3	76	1	0	0	0	0	1	0	0	0	16378	913	32	5	445	5	TP53	17	7577097	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	6025332	7577097	73618113	75	5134											
KDM6B	23135	broad.mit.edu	37	chr17	7752755	7752755	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccaagccacccacagctcCagcccctccatcagctcctg	7	21	1	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr17:7752755C>T	uc002giw.1	+	11	3525	c.3149C>T	c.(3148-3150)CCA>CTA	p.P1050L	KDM6B_uc002gix.2_Missense_Mutation_p.P352L	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1050	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCCACAGCTCCAGCCCCTCCA	0.677													T	7752755	T	T	7752755	3	4	76	1	0	0	0	0	1	0	0	0	8138	594	21	3	3179	3	KDM6B	17	7752755	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	175658	7752755	73442455	76	5135											
GRB7	2886	broad.mit.edu	37	chr17	37902194	37902194	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgcacccaactctggttccaCgggcgcatttcccgtgagga	11	15	1	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr17:37902194C>A	uc002hsr.2	+	13	1549	c.1299C>A	c.(1297-1299)CAC>CAA	p.H433Q	GRB7_uc002hss.2_Missense_Mutation_p.H433Q|GRB7_uc010cwc.2_Missense_Mutation_p.H433Q|GRB7_uc002hst.2_Intron	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	433	SH2.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCTGGTTCCACGGGCGCATTT	0.617													A	37902194	A	A	37902194	3	1	76	1	0	0	0	0	1	0	0	0	6759	535	19	5	1345	5	GRB7	17	37902194	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	30149439	37902194	43293016	77	5136											
GSDMA	284110	broad.mit.edu	37	chr17	38133285	38133285	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttatgcaggcctctctctcCttcagcagcttaccaaggcc	7	15	3	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr17:38133285C>T	uc002htl.1	+	12	1430	c.1312C>T	c.(1312-1314)CTT>TTT	p.L438F	GSDMA_uc002htm.1_Missense_Mutation_p.L438F	NM_178171	NP_835465	Q96QA5	GSDMA_HUMAN	gasdermin 1	438					apoptosis|induction of apoptosis	perinuclear region of cytoplasm					0						CCTCTCTCTCCTTCAGCAGCT	0.557													T	38133285	T	T	38133285	3	4	76	1	0	0	0	0	1	0	0	0	6816	681	24	3	1354	3	GSDMA	17	38133285	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	231091	38133285	43061925	78	5137											
KRTAP4-9	100132386	broad.mit.edu	37	chr17	39262218	39262218	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caccacttgctatcgcccaaCctgtgtcatctccagctgcc	6	18	2	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr17:39262218C>A	uc010wfp.1	+	1	578	c.578C>A	c.(577-579)ACC>AAC	p.T193N		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	193						keratin filament					0						TATCGCCCAACCTGTGTCATC	0.483													A	39262218	A	A	39262218	3	1	76	1	0	0	0	0	1	0	0	0	8557	507	18	5	580	5	KRTAP4-9	17	39262218	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	1128933	39262218	41932992	79	5138											
MPO	4353	broad.mit.edu	37	chr17	56355275	56355275	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagggcagcagggcccggcCgttgtcttggaagcgctggt	17	10	1	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr17:56355275C>T	uc002ivu.1	-	7	1294	c.1117G>A	c.(1117-1119)GGC>AGC	p.G373S		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	373					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	AGGGCCCGGCCGTTGTCTTGG	0.652													T	56355275	T	T	56355275	3	4	76	1	0	0	0	0	1	0	0	0	9732	652	23	2	1144	2	MPO	17	56355275	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	17093057	56355275	24839935	80	5139											
DNAH17	8632	broad.mit.edu	37	chr17	76420030	76420030	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggctgccaggatccacttcGctgccttctctttggtcttc	9	15	2	0	rs143246806	byFrequency	TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr17:76420030G>A	uc010dhp.1	-	26	4568	c.4346C>T	c.(4345-4347)GCG>GTG	p.A1449V	PGS1_uc002jvm.2_Intron|PGS1_uc010wtt.1_Intron|PGS1_uc010dho.2_Intron|PGS1_uc002jvn.2_Intron|PGS1_uc002jvo.2_Intron|DNAH17_uc002jvq.2_Missense_Mutation_p.A734V|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GATCCACTTCGCTGCCTTCTC	0.279													A	76420030	A	A	76420030	3	1	76	1	0	0	0	0	1	0	0	0	4601	1087	38	1	46	1	DNAH17	17	76420030	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	20064755	76420030	4775180	81	5140											
TCF4	6925	broad.mit.edu	37	chr18	52921829	52921829	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tccaatgattccatgcatgtCcccatgaccaccaggcatag	7	14	0	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr18:52921829C>T	uc002lfz.2	-	15	1861	c.1249G>A	c.(1249-1251)GAC>AAC	p.D417N	TCF4_uc002lfw.3_Missense_Mutation_p.D257N|TCF4_uc010xdu.1_Missense_Mutation_p.D287N|TCF4_uc010xdv.1_Missense_Mutation_p.D287N|TCF4_uc002lfx.2_Missense_Mutation_p.D346N|TCF4_uc010xdw.1_Missense_Mutation_p.D287N|TCF4_uc002lfy.2_Missense_Mutation_p.D375N|TCF4_uc010xdx.1_Missense_Mutation_p.D393N|TCF4_uc010dph.1_Missense_Mutation_p.D417N|TCF4_uc010xdy.1_Missense_Mutation_p.D393N|TCF4_uc002lga.2_Missense_Mutation_p.D519N|TCF4_uc002lgb.1_Missense_Mutation_p.D257N|TCF4_uc010dpi.2_Missense_Mutation_p.D423N|TCF4_uc002lfv.2_Missense_Mutation_p.D200N	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	417					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		CCATGCATGTCCCCATGACCA	0.502													T	52921829	T	T	52921829	3	4	76	1	0	0	0	0	1	0	0	0	15692	855	30	3	786	3	TCF4	18	52921829	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08		52921829	25155419	82	5141											
SOCS6	9306	broad.mit.edu	37	chr18	67992070	67992070	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagatatggccagctgcgatAtcaacggtgaagatgaaaaa	11	6	1	4			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr18:67992070A>G	uc002lkr.1	+	2	482	c.166A>G	c.(166-168)ATC>GTC	p.I56V	SOCS6_uc010dqq.2_Missense_Mutation_p.I56V	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	56					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				CAGCTGCGATATCAACGGTGA	0.428													G	67992070	G	G	67992070	3	3	76	1	0	0	0	0	1	0	0	0	14918	449	16	4	168	4	SOCS6	18	67992070	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	15070241	67992070	10085178	83	5142											
HMHA1	23526	broad.mit.edu	37	chr19	1083208	1083208	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcatcgtgttcgggcccacGctgcttcggccacggcccac	13	17	0	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr19:1083208G>A	uc002lqz.1	+	21	3042	c.2811G>A	c.(2809-2811)ACG>ACA	p.T937T	HMHA1_uc010xgd.1_Silent_p.T953T|HMHA1_uc010xge.1_Silent_p.T805T|HMHA1_uc002lra.1_Silent_p.T777T|HMHA1_uc002lrb.1_Silent_p.T820T|HMHA1_uc002lrc.1_Silent_p.T572T|HMHA1_uc002lrd.1_Silent_p.T13T|HMHA1_uc010dsd.1_Silent_p.T43T	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	937	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGGCCCACGCTGCTTCGGC	0.672													A	1083208	A	A	1083208	2	1	76	1	0	0	0	0	0	0	0	1	7240	1074	38	1		1	HMHA1	19	1083208	Silent	SNP	G	TCGA-06-2558-01A-01D-1494-08		1083208	58045775	84	5143											
FARSA	2193	broad.mit.edu	37	chr19	13035595	13035595	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cggaatacgcggtcgatggaGaagtacttgaccggagtgaa	15	7	0	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr19:13035595G>A	uc002mvs.2	-	10	1101	c.1053C>T	c.(1051-1053)TTC>TTT	p.F351F	FARSA_uc002mvt.2_RNA|FARSA_uc010xmv.1_Silent_p.F320F|FARSA_uc010dyy.1_Silent_p.F272F	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	351					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)	GGTCGATGGAGAAGTACTTGA	0.612													A	13035595	A	A	13035595	2	1	76	1	0	0	0	0	0	0	0	1	5679	933	33	3		3	FARSA	19	13035595	Silent	SNP	G	TCGA-06-2558-01A-01D-1494-08	11952387	13035595	46093388	85	5144											
C20orf54	113278	broad.mit.edu	37	chr20	744614	744614	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggacaagggtgcttccattcCggggagggcggacaccaaag	16	10	0	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr20:744614C>T	uc002wed.3	-	3	940	c.601G>A	c.(601-603)GGA>AGA	p.G201R	C20orf54_uc002wee.2_Missense_Mutation_p.G201R	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	201					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						GCTTCCATTCCGGGGAGGGCG	0.587													T	744614	T	T	744614	3	4	76	1	0	0	0	0	1	0	0	0	2114	661	23	2	820	2	C20orf54	20	744614	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08		744614	62280906	86	5145											
PCSK2	5126	broad.mit.edu	37	chr20	17434509	17434509	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccatcaactcagccatcaaCgacggcaggactgccctgta	8	15	3	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr20:17434509C>T	uc002wpm.2	+	9	1328	c.1008C>T	c.(1006-1008)AAC>AAT	p.N336N	PCSK2_uc002wpl.2_Silent_p.N317N|PCSK2_uc010zrm.1_Silent_p.N301N	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	336	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAGCCATCAACGACGGCAGGA	0.617													T	17434509	T	T	17434509	2	4	76	1	0	0	0	0	0	0	0	1	11601	535	19	1		1	PCSK2	20	17434509	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08	16689895	17434509	45591011	87	5146											
PRIC285	85441	broad.mit.edu	37	chr20	62198633	62198633	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacctgcatgtggtcgcccGccagcacgaggcgggtgccg	16	14	0	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr20:62198633G>A	uc002yfm.2	-	7	2970	c.2078C>T	c.(2077-2079)GCG>GTG	p.A693V	PRIC285_uc002yfl.1_Missense_Mutation_p.A124V	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	693					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GTGGTCGCCCGCCAGCACGAG	0.682													A	62198633	A	A	62198633	3	1	76	1	0	0	0	0	1	0	0	0	12485	1087	38	1	5927	1	PRIC285	20	62198633	Missense_Mutation	SNP	G	TCGA-06-2558-01A-01D-1494-08	44764124	62198633	826887	88	5147											
SAMSN1	64092	broad.mit.edu	37	chr21	15858270	15858270	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgataataatcttatgtaccAtgtcagacagattttcagac	6	7	3	4			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chr21:15858270A>T	uc002yju.1	-	8	1167	c.1085T>A	c.(1084-1086)ATG>AAG	p.M362K	SAMSN1_uc010gky.1_Missense_Mutation_p.M194K|SAMSN1_uc002yjv.1_Missense_Mutation_p.M430K	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	362					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CTTATGTACCATGTCAGACAG	0.398													T	15858270	T	T	15858270	3	4	76	1	0	0	0	0	1	0	0	0	13830	217	8	5	40	5	SAMSN1	21	15858270	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08		15858270	32271625	89	5148											
PIR	8544	broad.mit.edu	37	chrX	15509315	15509315	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccaatgcttctccggaccctCgctccaaccccttccgactg	6	20	1	0			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chrX:15509315C>T	uc004cwu.2	-	2	304	c.66G>A	c.(64-66)GCG>GCA	p.A22A	PIR_uc004cwv.2_Silent_p.A22A|BMX_uc004cww.2_Intron	NM_003662	NP_003653	O00625	PIR_HUMAN	pirin	22					transcription from RNA polymerase II promoter	cytoplasm|nucleus	metal ion binding|protein binding|quercetin 2,3-dioxygenase activity|transcription cofactor activity			ovary(1)	1	Hepatocellular(33;0.183)					TCCGGACCCTCGCTCCAACCC	0.522													T	15509315	T	T	15509315	2	4	76	1	0	0	0	0	0	0	0	1	11944	871	31	2		2	PIR	23	15509315	Silent	SNP	C	TCGA-06-2558-01A-01D-1494-08		15509315	139761245	90	5149											
KLHL34	257240	broad.mit.edu	37	chrX	21675201	21675201	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggccagagcccgagtacaCgcgccgcagtacgtcggcgg	16	14	0	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chrX:21675201C>T	uc004czz.1	-	1	1248	c.706G>A	c.(706-708)GTG>ATG	p.V236M		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	236	BACK.									ovary(1)	1						CCCGAGTACACGCGCCGCAGT	0.667													T	21675201	T	T	21675201	3	4	76	1	0	0	0	0	1	0	0	0	8387	536	19	1	1232	1	KLHL34	23	21675201	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	6165886	21675201	133595359	91	5150											
FAM47B	170062	broad.mit.edu	37	chrX	34962438	34962438	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aacaaccgatcaagaccaaaAgattaagaaggcaaacgagt	8	8	1	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chrX:34962438A>T	uc004ddi.1	+	1	1508	c.1490A>T	c.(1489-1491)AAG>ATG	p.K497M		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	497										ovary(3)|breast(1)	4						CAAGACCAAAAGATTAAGAAG	0.468													T	34962438	T	T	34962438	3	4	76	1	0	0	0	0	1	0	0	0	5570	72	3	5	1492	5	FAM47B	23	34962438	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	13287237	34962438	120308122	92	5151											
CXorf27	25763	broad.mit.edu	37	chrX	37850145	37850145	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tacaaataacaaccagactcAagacccttctagaaatgagc	5	11	2	4			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chrX:37850145A>T	uc004ddt.3	+	1	76	c.53A>T	c.(52-54)CAA>CTA	p.Q18L		NM_012274	NP_036406	O75409	HYPM_HUMAN	Huntingtin interacting protein M	18							DNA binding			central_nervous_system(1)	1						AACCAGACTCAAGACCCTTCT	0.458													T	37850145	T	T	37850145	3	4	76	1	0	0	0	0	1	0	0	0	4105	130	5	5	55	5	CXorf27	23	37850145	Missense_Mutation	SNP	A	TCGA-06-2558-01A-01D-1494-08	2887707	37850145	117420415	93	5152											
BCOR	54880	broad.mit.edu	37	chrX	39921626	39921626	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaactgggctccggccgcttTctgaatctccggacagtcac	11	14	3	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chrX:39921626T>C	uc004den.3	-	10	4486	c.4194A>G	c.(4192-4194)AGA>AGG	p.R1398R	BCOR_uc004dep.3_Silent_p.R1364R|BCOR_uc004deo.3_Silent_p.R1346R|BCOR_uc010nhb.2_Silent_p.R106R|BCOR_uc004dem.3_Silent_p.R1364R	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1398					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CCGGCCGCTTTCTGAATCTCC	0.587													C	39921626	C	C	39921626	2	2	76	1	0	0	0	0	0	0	0	1	1386	1780	62	4		4	BCOR	23	39921626	Silent	SNP	T	TCGA-06-2558-01A-01D-1494-08	2071481	39921626	115348934	94	5153											
DGKK	139189	broad.mit.edu	37	chrX	50134485	50134485	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actctgttgaggatgtccagAggtgacttgcttttgttcca	11	8	1	3			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chrX:50134485A>C	uc010njr.1	-	11	1854	c.1794T>G	c.(1792-1794)CCT>CCG	p.P598P		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	598	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GGATGTCCAGAGGTGACTTGC	0.537													C	50134485	C	C	50134485	2	2	76	1	0	0	0	0	0	0	0	1	4472	291	11	5		5	DGKK	23	50134485	Silent	SNP	A	TCGA-06-2558-01A-01D-1494-08	10212859	50134485	105136075	95	5154											
NAP1L2	4674	broad.mit.edu	37	chrX	72433530	72433530	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttaatatctgtcaggagctTcagaataggctcatcatatt	7	7	5	1			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chrX:72433530T>A	uc004ebi.2	-	1	1155	c.799A>T	c.(799-801)AAG>TAG	p.K267*	NAP1L2_uc011mqj.1_Nonsense_Mutation_p.K125*	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	267					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					GTCAGGAGCTTCAGAATAGGC	0.368													A	72433530	A	A	72433530	4	1	76	1	0	0	0	0	0	1	0	0	10157	1792	62	5	587	5	NAP1L2	23	72433530	Nonsense_Mutation	SNP	T	TCGA-06-2558-01A-01D-1494-08	22299045	72433530	82837030	96	5155											
PCDH11X	27328	broad.mit.edu	37	chrX	91132696	91132696	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctcctggcatccagttgaCgaaagtaagtgcaatggatg	11	9	1	1	rs62621113		TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chrX:91132696C>T	uc004efk.1	+	2	2302	c.1457C>T	c.(1456-1458)ACG>ATG	p.T486M	PCDH11X_uc004efl.1_Missense_Mutation_p.T486M|PCDH11X_uc004efo.1_Missense_Mutation_p.T486M|PCDH11X_uc010nmv.1_Missense_Mutation_p.T486M|PCDH11X_uc004efm.1_Missense_Mutation_p.T486M|PCDH11X_uc004efn.1_Missense_Mutation_p.T486M|PCDH11X_uc004efh.1_Missense_Mutation_p.T486M|PCDH11X_uc004efj.1_Missense_Mutation_p.T486M	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	486	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ATCCAGTTGACGAAAGTAAGT	0.438													T	91132696	T	T	91132696	3	4	76	1	0	0	0	0	1	0	0	0	11508	536	19	1	1463	1	PCDH11X	23	91132696	Missense_Mutation	SNP	C	TCGA-06-2558-01A-01D-1494-08	18699166	91132696	64137864	97	5156											
FAM70A	55026	broad.mit.edu	37	chrX	119410875	119410875	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgctgacatcgatgtattcGtagtacccaccagtgatctc	8	12	1	2			TCGA-06-2558-01A-01D-1494-08	TCGA-06-2558-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	19f41e2f-cff9-4f04-ba65-6d945bf05edd	a699d990-8181-471d-8b54-4b71171c9142	g.chrX:119410875G>A	uc004eso.3	-	8	839	c.612C>T	c.(610-612)TAC>TAT	p.Y204Y	FAM70A_uc004esp.3_Silent_p.Y180Y|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	204						integral to membrane				lung(1)|breast(1)	2						CGATGTATTCGTAGTACCCAC	0.582													A	119410875	A	A	119410875	2	1	76	1	0	0	0	0	0	0	0	1	5605	1140	40	1		1	FAM70A	23	119410875	Silent	SNP	G	TCGA-06-2558-01A-01D-1494-08	28278179	119410875	35859685	98	5157											
MTHFR	4524	broad.mit.edu	37	chr1	11861244	11861244	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcagcgccatgatgttcttcAggcccagctgcttagctttg	11	12	2	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr1:11861244A>G	uc001atc.1	-	3	633	c.449T>C	c.(448-450)CTG>CCG	p.L150P	MTHFR_uc001atb.1_Missense_Mutation_p.L173P	NM_005957	NP_005948	P42898	MTHR_HUMAN	5,10-methylenetetrahydrofolate reductase	150					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	GATGTTCTTCAGGCCCAGCTG	0.602													G	11861244	G	G	11861244	3	3	77	1	0	0	0	0	1	0	0	0	9931	188	7	4	1561	4	MTHFR	1	11861244	Missense_Mutation	SNP	A	TCGA-06-2559-01A-01D-1494-08		11861244	237389377	1	5158											
IFI6	2537	broad.mit.edu	37	chr1	27992966	27992966	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaccaatattacctatgaCgacgctgctgccaccagccc	8	16	0	1	rs74937564		TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr1:27992966C>T	uc001boo.1	-	5	442	c.319G>A	c.(319-321)GTC>ATC	p.V107I	IFI6_uc001bon.1_Missense_Mutation_p.V115I|IFI6_uc001bop.1_Missense_Mutation_p.V111I	NM_002038	NP_002029	P09912	IFI6_HUMAN	interferon, alpha-inducible protein 6 isoform a	107					anti-apoptosis|negative regulation of caspase activity|negative regulation of mitochondrial depolarization|release of cytochrome c from mitochondria|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion	protein binding			ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;7.75e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TTACCTATGACGACGCTGCTG	0.537													T	27992966	T	T	27992966	3	4	77	1	0	0	0	0	1	0	0	0	7519	536	19	1	77	1	IFI6	1	27992966	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	16131722	27992966	221257655	2	5159											
LRRC40	55631	broad.mit.edu	37	chr1	70641517	70641517	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taatatcattgttgcttaggTcaagcctttccaaggaccgt	8	9	2	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr1:70641517T>G	uc001der.1	-	7	1005	c.953A>C	c.(952-954)GAC>GCC	p.D318A		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	318	LRR 11.									ovary(1)	1						GTTGCTTAGGTCAAGCCTTTC	0.289													G	70641517	G	G	70641517	3	3	77	1	0	0	0	0	1	0	0	0	8998	1667	58	5	891	5	LRRC40	1	70641517	Missense_Mutation	SNP	T	TCGA-06-2559-01A-01D-1494-08	42648551	70641517	178609104	3	5160											
NEXN	91624	broad.mit.edu	37	chr1	78392171	78392171	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catctggaaaaatgaaaaagAattttgaggatctagaaaaa	8	3	2	4			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr1:78392171A>T	uc001dic.3	+	7	859	c.562A>T	c.(562-564)AAT>TAT	p.N188Y	NEXN_uc001dia.3_Missense_Mutation_p.N174Y|NEXN_uc009wcb.1_Missense_Mutation_p.N110Y|NEXN_uc001dib.3_Missense_Mutation_p.N124Y|NEXN_uc001did.1_Missense_Mutation_p.N98Y|NEXN_uc001dif.1_Missense_Mutation_p.N80Y	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	188	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		AATGAAAAAGAATTTTGAGGA	0.313													T	78392171	T	T	78392171	3	4	77	1	0	0	0	0	1	0	0	0	10355	246	9	5	584	5	NEXN	1	78392171	Missense_Mutation	SNP	A	TCGA-06-2559-01A-01D-1494-08	7750654	78392171	170858450	4	5161											
WDR63	126820	broad.mit.edu	37	chr1	85560129	85560129	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atcagggctaatagctgtgtCggtagccgtgcgactttctt	12	9	2	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr1:85560129C>T	uc001dkt.2	+	10	1255	c.1064C>T	c.(1063-1065)TCG>TTG	p.S355L	WDR63_uc009wcl.2_Missense_Mutation_p.S316L	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	355										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		ATAGCTGTGTCGGTAGCCGTG	0.418													T	85560129	T	T	85560129	3	4	77	1	0	0	0	0	1	0	0	0	17311	893	31	2	1098	2	WDR63	1	85560129	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	7167958	85560129	163690492	5	5162											
HRNR	388697	broad.mit.edu	37	chr1	152192836	152192836	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccacgctggccgtggcctggAgactggccagatccagagct	14	14	0	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr1:152192836A>G	uc001ezt.1	-	3	1345	c.1269T>C	c.(1267-1269)TCT>TCC	p.S423S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	423	4.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTGGCCTGGAGACTGGCCAG	0.617													G	152192836	G	G	152192836	2	3	77	1	0	0	0	0	0	0	0	1	7359	291	11	4		4	HRNR	1	152192836	Silent	SNP	A	TCGA-06-2559-01A-01D-1494-08	66632707	152192836	97057785	6	5163											
SPTA1	6708	broad.mit.edu	37	chr1	158654966	158654966	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctccatgatccacttccCcagatcatctgcatctcgct	4	16	4	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr1:158654966C>T	uc001fst.1	-	2	395	c.196G>A	c.(196-198)GGG>AGG	p.G66R		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	66	Spectrin 2.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ATCCACTtccccagatcatct	0.299													T	158654966	T	T	158654966	3	4	77	1	0	0	0	0	1	0	0	0	15115	623	22	3	7267	3	SPTA1	1	158654966	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	6462130	158654966	90595655	7	5164											
LTBP1	4052	broad.mit.edu	37	chr2	33335817	33335817	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagttgcggcaccttttcaGcgtgagtatagtcttatcaa	9	9	3	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr2:33335817G>A	uc002ros.2	+	4	1032	c.1032G>A	c.(1030-1032)CAG>CAA	p.Q344Q		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	344					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CACCTTTTCAGCGTGAGTATA	0.423													A	33335817	A	A	33335817	2	1	77	1	0	0	0	0	0	0	0	1	9073	985	34	3		3	LTBP1	2	33335817	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08		33335817	209863556	8	5165											
KRCC1	51315	broad.mit.edu	37	chr2	88327482	88327482	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tacggtttctatttccacctCtgttttctttctttggatgc	6	10	4	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr2:88327482C>T	uc002sso.1	-	4	995	c.601G>A	c.(601-603)GAG>AAG	p.E201K	KRCC1_uc002ssp.1_Missense_Mutation_p.E201K	NM_016618	NP_057702	Q9NPI7	KRCC1_HUMAN	lysine-rich coiled-coil 1	201	Lys-rich.|Potential.									ovary(1)	1						ATTTCCACCTCTGTTTTCTTT	0.398													T	88327482	T	T	88327482	3	4	77	1	0	0	0	0	1	0	0	0	8441	922	32	3	182	3	KRCC1	2	88327482	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	54991665	88327482	154871891	9	5166											
IL18RAP	8807	broad.mit.edu	37	chr2	103057838	103057838	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cacactggaagtagaacttgGtaagctgggcctcatcgcct	11	11	1	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr2:103057838G>T	uc002tbx.2	+	7	1280	c.796_splice	c.e7+1	p.G266_splice	IL18RAP_uc010fiz.2_Splice_Site_p.G124_splice	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein						cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						GTAGAACTTGGTAAGCTGGGC	0.343													T	103057838	T	T	103057838	5	4	77	1	0	0	0	0	0	0	1	0	7648	1275	44	5	815	5	IL18RAP	2	103057838	Splice_Site	SNP	G	TCGA-06-2559-01A-01D-1494-08	14730356	103057838	140141535	10	5167											
LRP2	4036	broad.mit.edu	37	chr2	170009381	170009381	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaggtcaacttcctgcacaAgattattgcggccggattca	9	11	3	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr2:170009381A>G	uc002ues.2	-	67	12602	c.12389T>C	c.(12388-12390)CTT>CCT	p.L4130P		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4130	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTCCTGCACAAGATTATTGCG	0.478													G	170009381	G	G	170009381	3	3	77	1	0	0	0	0	1	0	0	0	8956	72	3	4	1630	4	LRP2	2	170009381	Missense_Mutation	SNP	A	TCGA-06-2559-01A-01D-1494-08	66951543	170009381	73189992	11	5168											
LRP2	4036	broad.mit.edu	37	chr2	170101420	170101420	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccccatggccacaggtgaaCgccgaagatgaacaggtatt	11	11	0	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr2:170101420C>T	uc002ues.2	-	22	3426	c.3213G>A	c.(3211-3213)GCG>GCA	p.A1071A	LRP2_uc010zdf.1_Silent_p.A934A	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1071	LDL-receptor class A 9.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CACAGGTGAACGCCGAAGATG	0.473													T	170101420	T	T	170101420	2	4	77	1	0	0	0	0	0	0	0	1	8956	523	19	1		1	LRP2	2	170101420	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	92039	170101420	73097953	12	5169											
UBR3	130507	broad.mit.edu	37	chr2	170929938	170929940	+	In_Frame_Del	DEL	GAA	-	-													tcctatttcatgtctaaaagGaagaagaagaattttcagtt							TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr2:170929938_170929940delGAA	uc010zdi.1	+	36	5020_5022	c.5020_5022delGAA	c.(5020-5022)GAAdel	p.E1677del	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_In_Frame_Del_p.E498del|UBR3_uc002uft.3_In_Frame_Del_p.E534del|UBR3_uc010zdj.1_In_Frame_Del_p.E368del|UBR3_uc002ufu.3_In_Frame_Del_p.E183del	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1677					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						TGTCTAAAAGGAAGAAGAAGAAT	0.379													-	170929940	-	-	170929938	7	5	77	1	0	1	0	1	0	0	0	0	16900	1188	41	0	5162	0	UBR3	2	170929938	In_Frame_Del	DEL	GAA	TCGA-06-2559-01A-01D-1494-08	828518	170929938	72269435	13	5170											
AOX1	316	broad.mit.edu	37	chr2	201478598	201478598	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtctcccttttgggctcggCgccaggtgggaaagtggagt	16	9	1	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr2:201478598C>T	uc002uvx.2	+	15	1621	c.1520C>T	c.(1519-1521)GCG>GTG	p.A507V	AOX1_uc010zhf.1_Missense_Mutation_p.A63V|AOX1_uc010fsu.2_5'UTR	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	507					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TTGGGCTCGGCGCCAGGTGGG	0.473													T	201478598	T	T	201478598	3	4	77	1	0	0	0	0	1	0	0	0	729	768	27	1	1578	1	AOX1	2	201478598	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	30548660	201478598	41720775	14	5171											
TMPPE	643853	broad.mit.edu	37	chr3	33134390	33134390	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tacccagcctcatgggtatcCcgtagtaggctgtgcctggg	13	12	1	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr3:33134390C>A	uc003cfk.2	-	2	1489	c.1298G>T	c.(1297-1299)GGG>GTG	p.G433V	GLB1_uc003cfh.1_Intron|GLB1_uc003cfi.1_Intron|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Intron|TMPPE_uc011axl.1_Missense_Mutation_p.G296V	NM_001039770	NP_001034859	Q6ZT21	TMPPE_HUMAN	transmembrane protein with	433						integral to membrane	metal ion binding				0						CATGGGTATCCCGTAGTAGGC	0.592													A	33134390	A	A	33134390	3	1	77	1	0	0	0	0	1	0	0	0	16235	623	22	5	67	5	TMPPE	3	33134390	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08		33134390	164888040	15	5172											
TMF1	7110	broad.mit.edu	37	chr3	69075241	69075241	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgctagaaacagaaaatggcTtgcgttccttagggagtaaa	11	6	0	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr3:69075241T>C	uc003dnn.2	-	14	3012	c.2765A>G	c.(2764-2766)AAG>AGG	p.K922R	TMF1_uc011bfx.1_Missense_Mutation_p.K925R	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	922	Potential.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		AGAAAATGGCTTGCGTTCCTT	0.393													C	69075241	C	C	69075241	3	2	77	1	0	0	0	0	1	0	0	0	16225	1609	56	4	532	4	TMF1	3	69075241	Missense_Mutation	SNP	T	TCGA-06-2559-01A-01D-1494-08	35940851	69075241	128947189	16	5173											
CPN2	1370	broad.mit.edu	37	chr3	194062679	194062679	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcggcaggtgcgtgatggcGttgcgttgcagccacagcct	16	11	0	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr3:194062679G>A	uc003fts.2	-	2	843	c.753C>T	c.(751-753)AAC>AAT	p.N251N		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	251	LRR 7.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GCGTGATGGCGTTGCGTTGCA	0.602													A	194062679	A	A	194062679	2	1	77	1	0	0	0	0	0	0	0	1	3810	1136	40	1		1	CPN2	3	194062679	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08	124987438	194062679	3959751	17	5174											
RGS12	6002	broad.mit.edu	37	chr4	3432638	3432638	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccaacagcaccttgctgcCgccgccctccaccccccagg	7	24	0	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr4:3432638C>T	uc003ggw.2	+	17	4974	c.4070C>T	c.(4069-4071)CCG>CTG	p.P1357L	RGS12_uc003ggv.2_Missense_Mutation_p.P1357L|RGS12_uc003ggy.1_3'UTR|RGS12_uc003ggz.2_Missense_Mutation_p.P709L|RGS12_uc011bvs.1_3'UTR|RGS12_uc003gha.2_Missense_Mutation_p.P699L|RGS12_uc010icv.2_Missense_Mutation_p.P556L	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1357						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACCTTGCTGCCGCCGCCCTCC	0.667													T	3432638	T	T	3432638	3	4	77	1	0	0	0	0	1	0	0	0	13295	652	23	2	4190	2	RGS12	4	3432638	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08		3432638	187721638	18	5175											
GABRB1	2560	broad.mit.edu	37	chr4	47405592	47405592	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcaggagcgtatccacgactGtcactaagttttcgtctaaa	8	10	3	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr4:47405592G>T	uc003gxh.2	+	7	1073	c.699G>T	c.(697-699)CTG>CTT	p.L233L	GABRB1_uc011bze.1_Silent_p.L163L	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	233	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATCCACGACTGTCACTAAGTT	0.398													T	47405592	T	T	47405592	2	4	77	1	0	0	0	0	0	0	0	1	6166	1364	48	5		5	GABRB1	4	47405592	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08	43972954	47405592	143748684	19	5176											
PDGFRA	5156	broad.mit.edu	37	chr4	55133901	55133901	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgatgtggaaaagattcagGaaataaggtaaagaaactct	10	4	2	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr4:55133901G>A	uc003han.3	+	7	1445	c.1114G>A	c.(1114-1116)GAA>AAA	p.E372K	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.E266K|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	372	Ig-like C2-type 4.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AAAGATTCAGGAAATAAGGTA	0.463			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			A	55133901	A	A	55133901	3	1	77	1	0	0	0	0	1	0	0	0	11661	1175	41	3	1136	3	PDGFRA	4	55133901	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	7728309	55133901	136020375	20	5177											
PDGFRA	5156	broad.mit.edu	37	chr4	55144136	55144136	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	actcacctggggccacatttGaacattgtaaacttgctggg	10	10	1	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr4:55144136G>C	uc003han.3	+	14	2296	c.1965G>C	c.(1963-1965)TTG>TTC	p.L655F	PDGFRA_uc003haa.2_Missense_Mutation_p.L415F|PDGFRA_uc010igq.1_Missense_Mutation_p.L549F|PDGFRA_uc003ham.2_RNA|PDGFRA_uc003hao.1_Missense_Mutation_p.L34F	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	655	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GGCCACATTTGAACATTGTAA	0.458			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			C	55144136	C	C	55144136	3	2	77	1	0	0	0	0	1	0	0	0	11661	1281	45	5	2015	5	PDGFRA	4	55144136	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	10235	55144136	136010140	21	5178											
CLOCK	9575	broad.mit.edu	37	chr4	56304530	56304532	+	In_Frame_Del	DEL	CTG	-	-													agctgctgctcctgggagctCtgctgctgctgctgctgcgt							TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr4:56304530_56304532delCTG	uc003haz.1	-	23	3204_3206	c.2278_2280delCAG	c.(2278-2280)CAGdel	p.Q760del	CLOCK_uc003hba.1_In_Frame_Del_p.Q760del|CLOCK_uc010igu.1_RNA	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	760	Gln-rich.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			cctgggagctctgctgctgctgc	0.315													-	56304532	-	-	56304530	7	5	77	1	0	1	0	1	0	0	0	0	3549	912	32	0	268	0	CLOCK	4	56304530	In_Frame_Del	DEL	CTG	TCGA-06-2559-01A-01D-1494-08	1160394	56304530	134849746	22	5179											
GRID2	2895	broad.mit.edu	37	chr4	94411879	94411879	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgttatctcatcttacacgGcaaacctcgctgctttcctc	5	14	2	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr4:94411879G>A	uc011cdt.1	+	12	2206	c.1948G>A	c.(1948-1950)GCA>ACA	p.A650T	GRID2_uc011cdu.1_Missense_Mutation_p.A555T	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	650	Helical; (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATCTTACACGGCAAACCTCGC	0.438													A	94411879	A	A	94411879	3	1	77	1	0	0	0	0	1	0	0	0	6772	1203	42	3	1994	3	GRID2	4	94411879	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	38107349	94411879	96742397	23	5180											
NEUROG2	63973	broad.mit.edu	37	chr4	113436257	113436257	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgccgcgttgaggttgtgCatgcggtttcgctcgcggtt	16	9	0	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr4:113436257C>T	uc003ias.2	-	2	702	c.375G>A	c.(373-375)ATG>ATA	p.M125I		NM_024019	NP_076924	Q9H2A3	NGN2_HUMAN	neurogenin 2	125	Helix-loop-helix motif.|Basic motif.				positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			skin(2)|central_nervous_system(1)	3		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		TGAGGTTGTGCATGCGGTTTC	0.672													T	113436257	T	T	113436257	3	4	77	1	0	0	0	0	1	0	0	0	10353	710	25	3	447	3	NEUROG2	4	113436257	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	19024378	113436257	77718019	24	5181											
PRDM9	56979	broad.mit.edu	37	chr5	23526957	23526957	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtctgcagggagtgtgggcGgggctttagctggcagtcag	19	7	2	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr5:23526957G>A	uc003jgo.2	+	11	1942	c.1760G>A	c.(1759-1761)CGG>CAG	p.R587Q		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	587	C2H2-type 4.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GAGTGTGGGCGGGGCTTTAGC	0.607										HNSCC(3;0.000094)			A	23526957	A	A	23526957	3	1	77	1	0	0	0	0	1	0	0	0	12463	1116	39	2	1798	2	PRDM9	5	23526957	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08		23526957	157388303	25	5182											
C5orf39	389289	broad.mit.edu	37	chr5	43040058	43040058	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	aggccacggcccacgatcttCtgaactcacaataggtggag	11	12	3	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr5:43040058C>A	uc003jnf.2	-	1	390	c.91G>T	c.(91-93)GAA>TAA	p.E31*	C5orf39_uc010ivj.1_RNA|LOC153684_uc003jng.2_5'Flank|LOC153684_uc003jni.2_5'Flank	NM_001014279	NP_001014301	Q3ZCQ2	AX2R_HUMAN	annexin II receptor	31							receptor activity				0						CCACGATCTTCTGAACTCACA	0.567											OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	43040058	A	A	43040058	4	1	77	1	0	0	0	0	0	1	0	0	2297	922	32	5	494	5	C5orf39	5	43040058	Nonsense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	19513101	43040058	137875202	26	5183											
MAP3K1	4214	broad.mit.edu	37	chr5	56168506	56168506	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaatagagaacctttaataTgtcccctttgtagatctaag	7	7	1	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr5:56168506T>C	uc003jqw.3	+	8	1963	c.1462T>C	c.(1462-1464)TGT>CGT	p.C488R		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	488	RING-type.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		ACCTTTAATATGTCCCCTTTG	0.279													C	56168506	C	C	56168506	3	2	77	1	0	0	0	0	1	0	0	0	9243	1464	51	4	1492	4	MAP3K1	5	56168506	Missense_Mutation	SNP	T	TCGA-06-2559-01A-01D-1494-08	13128448	56168506	124746754	27	5184											
GPR98	84059	broad.mit.edu	37	chr5	89989726	89989726	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggagggcactttggtcggCtgttgttgttctacagtact	14	8	1	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr5:89989726C>T	uc003kju.2	+	33	7249	c.7153C>T	c.(7153-7155)CTG>TTG	p.L2385L	GPR98_uc003kjt.2_Silent_p.L91L|GPR98_uc003kjv.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2385	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTTGGTCGGCTGTTGTTGTT	0.428													T	89989726	T	T	89989726	2	4	77	1	0	0	0	0	0	0	0	1	6721	796	28	3		3	GPR98	5	89989726	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	33821220	89989726	90925534	28	5185											
FBN2	2201	broad.mit.edu	37	chr5	127728841	127728841	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cacttacttagtccagtgatGataggtccctgtcccccggc	9	14	0	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr5:127728841G>T	uc003kuu.2	-	10	1891	c.1452C>A	c.(1450-1452)ATC>ATA	p.I484I	FBN2_uc003kuv.2_Silent_p.I451I	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	484					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GTCCAGTGATGATAGGTCCCT	0.498													T	127728841	T	T	127728841	2	4	77	1	0	0	0	0	0	0	0	1	5703	1280	45	5		5	FBN2	5	127728841	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08	37739115	127728841	53186419	29	5186											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768969	140768969	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatcctacgtgtccataagCgcggagagcggggtggtgtt	15	9	1	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr5:140768969C>T	uc003lkc.1	+	1	1518	c.1518C>T	c.(1516-1518)AGC>AGT	p.S506S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.S506S	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	506	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCCATAAGCGCGGAGAGCG	0.662													T	140768969	T	T	140768969	2	4	77	1	0	0	0	0	0	0	0	1	11565	767	27	1		1	PCDHGB4	5	140768969	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	13040128	140768969	40146291	30	5187											
UHRF1BP1	54887	broad.mit.edu	37	chr6	34827265	34827265	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacctcaccaaggaagctgtGtccctgactaaggatgcctt	10	12	1	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr6:34827265G>A	uc003oju.3	+	14	3366	c.3132G>A	c.(3130-3132)GTG>GTA	p.V1044V	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1044										ovary(3)	3						AGGAAGCTGTGTCCCTGACTA	0.517													A	34827265	A	A	34827265	2	1	77	1	0	0	0	0	0	0	0	1	16965	1364	48	3		3	UHRF1BP1	6	34827265	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08		34827265	136287802	31	5188											
ZNF735	730291	broad.mit.edu	37	chr7	63680474	63680474	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacataagataattcatactGgagagaaaccctacacatgt	6	9	1	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr7:63680474G>A	uc011kdn.1	+	4	1045	c.1045G>A	c.(1045-1047)GGA>AGA	p.G349R		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AATTCATACTGGAGAGAAACC	0.403													A	63680474	A	A	63680474	3	1	77	1	0	0	0	0	1	0	0	0	18121	1349	47	3	1059	3	ZNF735	7	63680474	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08		63680474	95458189	32	5189											
TAF6	6878	broad.mit.edu	37	chr7	99706049	99706049	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgcagagcagcctgggcccGagccttgaccacctgggagc	14	15	0	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr7:99706049G>A	uc003uti.2	-	13	1480	c.1399C>T	c.(1399-1401)CGG>TGG	p.R467W	AP4M1_uc003utd.2_Intron|TAF6_uc003utg.2_Missense_Mutation_p.R389W|TAF6_uc003uth.2_Missense_Mutation_p.R524W|TAF6_uc003utk.2_Missense_Mutation_p.R467W|TAF6_uc011kji.1_Missense_Mutation_p.R504W|TAF6_uc003utj.2_Missense_Mutation_p.R457W|TAF6_uc003utl.2_Missense_Mutation_p.R467W|TAF6_uc003utm.2_Missense_Mutation_p.R467W	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	467					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCTGGGCCCGAGCCTTGACC	0.642													A	99706049	A	A	99706049	3	1	77	1	0	0	0	0	1	0	0	0	15527	1057	37	2	646	2	TAF6	7	99706049	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	36025575	99706049	59432614	33	5190											
GRM8	2918	broad.mit.edu	37	chr7	126173406	126173406	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagatttcttcccctgctcaAatattcggtggatacggttt	8	10	2	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr7:126173406A>G	uc003vlr.2	-	8	2341	c.2030T>C	c.(2029-2031)TTT>TCT	p.F677S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.F677S|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	677	Cytoplasmic (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCCCTGCTCAAATATTCGGTG	0.502										HNSCC(24;0.065)			G	126173406	G	G	126173406	3	3	77	1	0	0	0	0	1	0	0	0	6803	14	1	4	758	4	GRM8	7	126173406	Missense_Mutation	SNP	A	TCGA-06-2559-01A-01D-1494-08	26467357	126173406	32965257	34	5191											
UBN2	254048	broad.mit.edu	37	chr7	138969015	138969015	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtggaatgaacatcagcagaCagtctcccaccttgaattta	8	10	2	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr7:138969015C>A	uc011kqr.1	+	15	3364	c.3364C>A	c.(3364-3366)CAG>AAG	p.Q1122K		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1122	Ser-rich.									ovary(1)|skin(1)	2						CATCAGCAGACAGTCTCCCAC	0.498													A	138969015	A	A	138969015	3	1	77	1	0	0	0	0	1	0	0	0	16890	479	17	5	3422	5	UBN2	7	138969015	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	12795609	138969015	20169648	35	5192											
ARHGEF10	9639	broad.mit.edu	37	chr8	1871717	1871717	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagatgaaatcagagctgcGgactgctgcagaattcagtt	12	7	2	4			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr8:1871717G>A	uc003wpr.2	+	20	2521	c.2343G>A	c.(2341-2343)GCG>GCA	p.A781A	ARHGEF10_uc003wpq.1_Silent_p.A805A|ARHGEF10_uc003wps.2_Silent_p.A743A|ARHGEF10_uc003wpv.2_Silent_p.A514A|ARHGEF10_uc010lre.2_Silent_p.A461A	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	806					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TCAGAGCTGCGGACTGCTGCA	0.418													A	1871717	A	A	1871717	2	1	77	1	0	0	0	0	0	0	0	1	894	1103	39	2		2	ARHGEF10	8	1871717	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08		1871717	144492305	36	5193											
CTHRC1	115908	broad.mit.edu	37	chr8	104390318	104390318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttttgttcagtggctcacttCggctaaaatgcagaaatgca	9	8	2	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr8:104390318C>T	uc003ylk.2	+	3	535	c.436C>T	c.(436-438)CGG>TGG	p.R146W		NM_138455	NP_612464	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	146						collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			TGGCTCACTTCGGCTAAAATG	0.373													T	104390318	T	T	104390318	3	4	77	1	0	0	0	0	1	0	0	0	4010	875	31	2	446	2	CTHRC1	8	104390318	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	102518601	104390318	41973704	37	5194											
TG	7038	broad.mit.edu	37	chr8	134042090	134042090	+	Frame_Shift_Del	DEL	G	-	-													cggagaggtgagtggcaactGggggctgctggaccaggtgg							TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr8:134042090delG	uc003ytw.2	+	41	7102	c.7061delG	c.(7060-7062)TGGfs	p.W2354fs	TG_uc010mdw.2_Frame_Shift_Del_p.W1113fs|TG_uc011ljb.1_Frame_Shift_Del_p.W723fs|TG_uc011ljc.1_Frame_Shift_Del_p.W487fs	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2354					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGTGGCAACTGGGGGCTGCTG	0.577													-	134042090	-	-	134042090	7	5	77	1	0	1	0	1	0	0	0	0	15810	1357	47	0	7223	0	TG	8	134042090	Frame_Shift_Del	DEL	G	TCGA-06-2559-01A-01D-1494-08	29651772	134042090	12321932	38	5195											
DOCK8	81704	broad.mit.edu	37	chr9	439266	439266	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	atatttcttccaatgtgctgGaggagtctgtggtctctgag	12	7	3	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr9:439266G>C	uc003zgf.2	+	40	5213	c.5101G>C	c.(5101-5103)GAG>CAG	p.E1701Q	DOCK8_uc010mgu.2_Missense_Mutation_p.E1003Q|DOCK8_uc010mgv.2_Missense_Mutation_p.E1601Q|DOCK8_uc003zgk.2_Missense_Mutation_p.E1159Q	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1701	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CAATGTGCTGGAGGAGTCTGT	0.552													C	439266	C	C	439266	3	2	77	1	0	0	0	0	1	0	0	0	4693	1175	41	5	5259	5	DOCK8	9	439266	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08		439266	140774165	39	5196											
KIAA1797	54914	broad.mit.edu	37	chr9	20821058	20821058	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agcagcatcaatcagagataTatgtaagcagaggtatgatg	11	5	2	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr9:20821058T>C	uc003zog.1	+	16	2144	c.1781T>C	c.(1780-1782)ATA>ACA	p.I594T	KIAA1797_uc003zoh.1_Missense_Mutation_p.I30T	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	594						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		ATCAGAGATATATGTAAGCAG	0.363													C	20821058	C	C	20821058	3	2	77	1	0	0	0	0	1	0	0	0	8258	1406	49	4	1831	4	KIAA1797	9	20821058	Missense_Mutation	SNP	T	TCGA-06-2559-01A-01D-1494-08	20381792	20821058	120392373	40	5197											
TAF1L	138474	broad.mit.edu	37	chr9	32630579	32630579	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgtgttggtatcatacatatCaggaggctgagatgtgtagg	14	4	2	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr9:32630579C>T	uc003zrg.1	-	1	5089	c.4999G>A	c.(4999-5001)GAT>AAT	p.D1667N	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1667					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCATACATATCAGGAGGCTGA	0.463													T	32630579	T	T	32630579	3	4	77	1	0	0	0	0	1	0	0	0	15520	826	29	3	485	3	TAF1L	9	32630579	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	11809521	32630579	108582852	41	5198											
ZNF658	26149	broad.mit.edu	37	chr9	40772401	40772401	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gatttctcccctgtgtgaatTctttgatgtactctgagggt	10	8	3	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr9:40772401T>A	uc004abs.2	-	5	3026	c.2874A>T	c.(2872-2874)AGA>AGT	p.R958S	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.R958S	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	958	C2H2-type 21.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CTGTGTGAATTCTTTGATGTA	0.438													A	40772401	A	A	40772401	3	1	77	1	0	0	0	0	1	0	0	0	18066	1780	62	5	309	5	ZNF658	9	40772401	Missense_Mutation	SNP	T	TCGA-06-2559-01A-01D-1494-08	8141822	40772401	100441030	42	5199											
TNFSF8	944	broad.mit.edu	37	chr9	117666360	117666360	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgagagagattctggtataCgtgtttcgtttgcattccag	11	6	1	2	rs145748228		TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr9:117666360C>T	uc004bji.1	-	4	743	c.556G>A	c.(556-558)GTA>ATA	p.V186I		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	186	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						TTCTGGTATACGTGTTTCGTT	0.418													T	117666360	T	T	117666360	3	4	77	1	0	0	0	0	1	0	0	0	16308	536	19	1	152	1	TNFSF8	9	117666360	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	76893959	117666360	23547071	43	5200											
ANKRD30A	91074	broad.mit.edu	37	chr10	37506710	37506710	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaattaggaagaatcgaagaGcagcataggaaagagttaga	13	3	0	4			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr10:37506710G>A	uc001iza.1	+	33	3102	c.3003G>A	c.(3001-3003)GAG>GAA	p.E1001E		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1057	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GAATCGAAGAGCAGCATAGGA	0.328													A	37506710	A	A	37506710	2	1	77	1	0	0	0	0	0	0	0	1	658	962	34	3		3	ANKRD30A	10	37506710	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08		37506710	98028037	44	5201											
ADAMTS14	140766	broad.mit.edu	37	chr10	72495039	72495039	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctttgactttggcagtggCtaccagacctgcttggcagt	12	11	0	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr10:72495039C>T	uc001jrh.2	+	9	1467	c.1467C>T	c.(1465-1467)GGC>GGT	p.G489G	ADAMTS14_uc001jrg.2_Silent_p.G492G|ADAMTS14_uc001jri.1_Silent_p.G12G	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	489	Disintegrin.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						TTGGCAGTGGCTACCAGACCT	0.592													T	72495039	T	T	72495039	2	4	77	1	0	0	0	0	0	0	0	1	259	784	28	3		3	ADAMTS14	10	72495039	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	34988329	72495039	63039708	45	5202											
PTEN	5728	broad.mit.edu	37	chr10	89692993	89692993	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gatttctatggggaagtaagGaccagagacaaaaaggtaag	13	4	1	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr10:89692993G>T	uc001kfb.2	+	6	1508	c.477G>T	c.(475-477)AGG>AGT	p.R159S		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	159	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R159S(4)|p.R55fs*1(4)|p.R159K(4)|p.?(2)|p.Y27fs*1(2)|p.R159fs*8(2)|p.Y27_N212>Y(2)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGGAAGTAAGGACCAGAGACA	0.358		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89692993	T	T	89692993	3	4	77	1	0	0	0	0	1	0	0	0	12738	1165	41	5	495	5	PTEN	10	89692993	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	17197954	89692993	45841754	46	5203											
PTEN	5728	broad.mit.edu	37	chr10	89720852	89720852	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaataaagacaaagccaacCgatacttttctccaaatttt	3	10	1	1	rs121909231		TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr10:89720852C>T	uc001kfb.2	+	9	2034	c.1003C>T	c.(1003-1005)CGA>TGA	p.R335*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	335	C2 tensin-type.			KANKDKANR->AAGADAANA: Reduces growth suppression activity and promotes anchorage-independent growth. Reduces binding to phospholipid membranes in vitro; phosphatase activity towards PtdIns(3,4,5)P3 is not affected.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R335*(21)|p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.R335fs*8(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.R335fs*4(1)|p.R335fs*7(1)|p.W274_F341del(1)|p.R335R(1)|p.D326_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CAAAGCCAACCGATACTTTTC	0.333		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89720852	T	T	89720852	4	4	77	1	0	0	0	0	0	1	0	0	12738	644	23	2	1033	2	PTEN	10	89720852	Nonsense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	27859	89720852	45813895	47	5204											
COL17A1	1308	broad.mit.edu	37	chr10	105798253	105798253	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggcccagggggccctggcGggcctgacacgtacatggta	18	12	0	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr10:105798253G>A	uc001kxr.2	-	45	3150	c.2981C>T	c.(2980-2982)CCG>CTG	p.P994L		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	994	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGGCCCTGGCGGGCCTGACAC	0.597													A	105798253	A	A	105798253	3	1	77	1	0	0	0	0	1	0	0	0	3674	1116	39	2	1560	2	COL17A1	10	105798253	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	16077401	105798253	29736494	48	5205											
NANOS1	340719	broad.mit.edu	37	chr10	120790044	120790044	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcgagtgctgtgtcccgtgcTgcgccgctacacgtgtcccc	13	16	0	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr10:120790044T>A	uc009xzf.1	+	1	817	c.731T>A	c.(730-732)CTG>CAG	p.L244Q		NM_199461	NP_955631	Q8WY41	NANO1_HUMAN	nanos homolog 1	244	Nanos-type.				epithelial cell migration	perinuclear region of cytoplasm	protein binding|RNA binding|translation repressor activity|zinc ion binding				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0193)		TGTCCCGTGCTGCGCCGCTAC	0.577													A	120790044	A	A	120790044	3	1	77	1	0	0	0	0	1	0	0	0	10151	1580	55	5	733	5	NANOS1	10	120790044	Missense_Mutation	SNP	T	TCGA-06-2559-01A-01D-1494-08	14991791	120790044	14744703	49	5206											
OR10S1	219873	broad.mit.edu	37	chr11	123847486	123847486	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcttcacctccttgttccGcaaagtgtaaatgaatgggt	9	9	1	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr11:123847486G>A	uc001pzm.1	-	1	913	c.913C>T	c.(913-915)CGG>TGG	p.R305W		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TCCTTGTTCCGCAAAGTGTAA	0.527													A	123847486	A	A	123847486	3	1	77	1	0	0	0	0	1	0	0	0	10918	1086	38	1	86	1	OR10S1	11	123847486	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08		123847486	11159030	50	5207											
AGAP2	116986	broad.mit.edu	37	chr12	58125706	58125706	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaccaacattcggtgaggaCgggagggaagaagagtagtc	16	6	0	4	rs145122115		TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr12:58125706C>T	uc001spq.2	-	8	1839	c.1839G>A	c.(1837-1839)CCG>CCA	p.P613P	AGAP2_uc001spp.2_Silent_p.P613P|AGAP2_uc001spr.2_Silent_p.P277P	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	613					axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						TCGGTGAGGACGGGAGGGAAG	0.622													T	58125706	T	T	58125706	2	4	77	1	0	0	0	0	0	0	0	1	368	523	19	1		1	AGAP2	12	58125706	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08		58125706	75726189	51	5208											
GPR133	283383	broad.mit.edu	37	chr12	131487809	131487809	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccaacctgcacggcagcaCgccccaggtcaccgtggagg	12	17	1	0	rs142314859		TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr12:131487809C>T	uc001uit.3	+	10	1665	c.1106C>T	c.(1105-1107)ACG>ATG	p.T369M	GPR133_uc010tbm.1_Missense_Mutation_p.T401M	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	369	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CACGGCAGCACGCCCCAGGTC	0.622													T	131487809	T	T	131487809	3	4	77	1	0	0	0	0	1	0	0	0	6643	536	19	1	1144	1	GPR133	12	131487809	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	73362103	131487809	2364086	52	5209											
N6AMT2	221143	broad.mit.edu	37	chr13	21331636	21331636	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgttatatttatcatcctcGcctggctcaatttgttgctt	6	9	2	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr13:21331636G>A	uc001uno.1	-	2	183	c.102C>T	c.(100-102)GGC>GGT	p.G34G	N6AMT2_uc009zzr.1_Silent_p.G34G|N6AMT2_uc001unp.2_RNA	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	34							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TATCATCCTCGCCTGGCTCAA	0.418													A	21331636	A	A	21331636	2	1	77	1	0	0	0	0	0	0	0	1	10115	1074	38	1		1	N6AMT2	13	21331636	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08		21331636	93838242	53	5210											
CHD8	57680	broad.mit.edu	37	chr14	21876530	21876530	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgcctgctggccagactgcCatggtacacaatagtgttca	10	12	1	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr14:21876530C>G	uc001was.1	-	13	1928	c.1834G>C	c.(1834-1836)GGC>CGC	p.G612R	CHD8_uc001war.1_Missense_Mutation_p.G508R|CHD8_uc001wav.1_Missense_Mutation_p.G54R	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	891	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GCCAGACTGCCATGGTACACA	0.438													G	21876530	G	G	21876530	3	3	77	1	0	0	0	0	1	0	0	0	3331	594	21	5	5178	5	CHD8	14	21876530	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08		21876530	85473010	54	5211											
DHRS2	10202	broad.mit.edu	37	chr14	24109023	24109023	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccctggagcactgtgggggCgtcgacttcctggtgtgcag	17	11	0	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr14:24109023C>T	uc001wkt.3	+	4	786	c.339C>T	c.(337-339)GGC>GGT	p.G113G	DHRS2_uc010aku.1_Silent_p.G113G|DHRS2_uc001wku.3_Silent_p.G113G|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Silent_p.G113G	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	91					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		ACTGTGGGGGCGTCGACTTCC	0.637													T	24109023	T	T	24109023	2	4	77	1	0	0	0	0	0	0	0	1	4490	755	27	1		1	DHRS2	14	24109023	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	2232493	24109023	83240517	55	5212											
LRRC16B	90668	broad.mit.edu	37	chr14	24524519	24524519	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcagccacttggagagccGgtaagcagatggggcagaga	15	8	1	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr14:24524519G>A	uc001wlj.2	+	8	762	c.605G>A	c.(604-606)CGA>CAA	p.R202Q		NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	202										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		TTGGAGAGCCGGTAAGCAGAT	0.552													A	24524519	A	A	24524519	3	1	77	1	0	0	0	0	1	0	0	0	8972	1130	39	2	635	2	LRRC16B	14	24524519	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	415496	24524519	82825021	56	5213											
C15orf2	23742	broad.mit.edu	37	chr15	24921169	24921169	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctttccgcggcctgttccGccggaacgcccgtcgcaggc	12	19	0	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr15:24921169G>A	uc001ywo.2	+	1	629	c.155G>A	c.(154-156)CGC>CAC	p.R52H		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	52					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GGCCTGTTCCGCCGGAACGCC	0.756													A	24921169	A	A	24921169	3	1	77	1	0	0	0	0	1	0	0	0	1784	1087	38	1	157	1	C15orf2	15	24921169	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08		24921169	77610223	57	5214											
SOLH	6650	broad.mit.edu	37	chr16	603459	603459	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggacagcctccaaggggacCcacagccccccactcacgcc	9	20	1	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr16:603459C>T	uc002chi.2	+	14	3567	c.3204C>T	c.(3202-3204)ACC>ACT	p.T1068T	SOLH_uc002chj.2_Silent_p.T128T	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	1068					proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				CCAAGGGGACCCACAGCCCCC	0.687													T	603459	T	T	603459	2	4	77	1	0	0	0	0	0	0	0	1	14925	610	22	3		3	SOLH	16	603459	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08		603459	89751294	58	5215											
WDR90	197335	broad.mit.edu	37	chr16	715745	715745	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagtgaggatgggagtgtgCgggtgtgggccttggccagc	21	7	0	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr16:715745C>T	uc002cii.1	+	35	4432	c.4378C>T	c.(4378-4380)CGG>TGG	p.R1460W	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Missense_Mutation_p.R75W|WDR90_uc010uul.1_Missense_Mutation_p.R59W|WDR90_uc002cio.1_Missense_Mutation_p.R59W|WDR90_uc010bqx.1_Missense_Mutation_p.R59W|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1460	WD 17.									ovary(1)	1		Hepatocellular(780;0.0218)				TGGGAGTGTGCGGGTGTGGGC	0.672													T	715745	T	T	715745	3	4	77	1	0	0	0	0	1	0	0	0	17334	759	27	1	4516	1	WDR90	16	715745	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	112286	715745	89639008	59	5216											
OTOA	146183	broad.mit.edu	37	chr16	21698817	21698817	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtgaaccgcagcctgtttctCatcacactggagaggtgttt	11	10	2	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr16:21698817C>T	uc002djh.2	+	7	484	c.483C>T	c.(481-483)CTC>CTT	p.L161L	uc002diq.3_Intron|OTOA_uc010vbj.1_Silent_p.L82L	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	161					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		GCCTGTTTCTCATCACACTGG	0.542													T	21698817	T	T	21698817	2	4	77	1	0	0	0	0	0	0	0	1	11302	813	29	3		3	OTOA	16	21698817	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	20983072	21698817	68655936	60	5217											
SCNN1G	6340	broad.mit.edu	37	chr16	23226433	23226433	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gagatgcttctgtccaacttCggtggccagctgggcctgtg	14	11	1	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr16:23226433C>A	uc002dlm.1	+	13	1732	c.1593C>A	c.(1591-1593)TTC>TTA	p.F531L		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	531	Helical; (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TGTCCAACTTCGGTGGCCAGC	0.547													A	23226433	A	A	23226433	3	1	77	1	0	0	0	0	1	0	0	0	13930	883	31	5	1639	5	SCNN1G	16	23226433	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	1527616	23226433	67128320	61	5218											
ITGAD	3681	broad.mit.edu	37	chr16	31409190	31409190	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctgcctcctgctgggctcGcgctgggagatcatccagac	12	15	1	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr16:31409190G>A	uc002ebv.1	+	5	436	c.387G>A	c.(385-387)TCG>TCA	p.S129S	ITGAD_uc010vfl.1_Silent_p.S129S|ITGAD_uc010cap.1_Silent_p.S129S|ITGAD_uc002ebw.1_5'UTR	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	129	FG-GAP 2.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TGCTGGGCTCGCGCTGGGAGA	0.642													A	31409190	A	A	31409190	2	1	77	1	0	0	0	0	0	0	0	1	7884	1074	38	1		1	ITGAD	16	31409190	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08	8182757	31409190	58945563	62	5219											
NLRC5	84166	broad.mit.edu	37	chr16	57054711	57054711	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagacccagaatggctgaaCgccaagatgaagttcttcct	9	10	1	5			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr16:57054711C>T	uc002ekk.1	+	3	312	c.87C>T	c.(85-87)AAC>AAT	p.N29N	NLRC5_uc010ccq.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	29					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				AATGGCTGAACGCCAAGATGA	0.562													T	57054711	T	T	57054711	2	4	77	1	0	0	0	0	0	0	0	1	10470	535	19	1		1	NLRC5	16	57054711	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	25645521	57054711	33300042	63	5220											
NLRC5	84166	broad.mit.edu	37	chr16	57088674	57088674	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttttcaggctgagccagaCgggactgtccccgaaaagcc	11	14	1	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr16:57088674C>T	uc002ekk.1	+	25	3743	c.3518C>T	c.(3517-3519)ACG>ATG	p.T1173M	NLRC5_uc002ekn.2_Missense_Mutation_p.T892M|NLRC5_uc002ekl.2_Missense_Mutation_p.T978M|NLRC5_uc002ekm.2_Missense_Mutation_p.T948M|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekp.1_Missense_Mutation_p.T89M|NLRC5_uc002ekq.1_Translation_Start_Site|NLRC5_uc002ekr.1_Missense_Mutation_p.T89M	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1173	LRR 12.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CTGAGCCAGACGGGACTGTCC	0.592													T	57088674	T	T	57088674	3	4	77	1	0	0	0	0	1	0	0	0	10470	536	19	1	3608	1	NLRC5	16	57088674	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	33963	57088674	33266079	64	5221											
KCTD19	146212	broad.mit.edu	37	chr16	67325657	67325657	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagccatcgctgcccaccaCgggggggtgagtcactttga	14	12	1	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr16:67325657C>T	uc002esu.2	-	13	2353	c.2302G>A	c.(2302-2304)GTG>ATG	p.V768M	KCTD19_uc002est.2_Missense_Mutation_p.V540M|KCTD19_uc010vjj.1_Missense_Mutation_p.V511M	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	768						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CTGCCCACCACGGGGGGGTGA	0.572													T	67325657	T	T	67325657	3	4	77	1	0	0	0	0	1	0	0	0	8106	536	19	1	494	1	KCTD19	16	67325657	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	10236983	67325657	23029096	65	5222											
PKD1L2	114780	broad.mit.edu	37	chr16	81187697	81187697	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggagtgtcgggatcagccagGtggtggggctctctctctcc	16	11	3	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr16:81187697G>C	uc002fgh.1	-	26	4275	c.4275C>G	c.(4273-4275)CAC>CAG	p.H1425Q	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1425	Cytoplasmic (Potential).|PLAT.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GATCAGCCAGGTGGTGGGGCT	0.607													C	81187697	C	C	81187697	3	2	77	1	0	0	0	0	1	0	0	0	11965	1252	44	5	3175	5	PKD1L2	16	81187697	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	13862040	81187697	9167056	66	5223											
TP53	7157	broad.mit.edu	37	chr17	7578280	7578280	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcggataagatgctgaggaGgggccagacctaagagcaat	14	8	0	4			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr17:7578280G>A	uc002gim.2	-	6	763	c.569C>T	c.(568-570)CCT>CTT	p.P190L	TP53_uc002gig.1_Missense_Mutation_p.P190L|TP53_uc002gih.2_Missense_Mutation_p.P190L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P58L|TP53_uc010cng.1_Missense_Mutation_p.P58L|TP53_uc002gii.1_Missense_Mutation_p.P58L|TP53_uc010cnh.1_Missense_Mutation_p.P190L|TP53_uc010cni.1_Missense_Mutation_p.P190L|TP53_uc002gij.2_Missense_Mutation_p.P190L|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.P97L|TP53_uc002gio.2_Missense_Mutation_p.P58L|TP53_uc010vug.1_Missense_Mutation_p.P151L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	190	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> H (in a sporadic cancer; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P190L(21)|p.P190fs*57(8)|p.0?(7)|p.P190del(6)|p.P190S(6)|p.P190T(4)|p.A189_V197delAPPQHLIRV(4)|p.G187fs*16(2)|p.P190A(2)|p.P190R(2)|p.K164_P219del(1)|p.P58fs*>33(1)|p.A189_Q192>E(1)|p.P191fs*18(1)|p.P190fs*19(1)|p.D186_P191delDGLAPP(1)|p.?(1)|p.A189fs*53(1)|p.P190H(1)|p.P190P(1)|p.L188_P191del(1)|p.P97fs*57(1)|p.A189_P190>X(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGCTGAGGAGGGGCCAGACC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578280	A	A	7578280	3	1	77	1	0	0	0	0	1	0	0	0	16378	1000	35	3	725	3	TP53	17	7578280	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08		7578280	73616930	67	5224											
TP53	7157	broad.mit.edu	37	chr17	7578466	7578466	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggccatggcgcggacgcggGtgccgggcgggggtgtggaa	23	9	0	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr17:7578466G>T	uc002gim.2	-	5	658	c.464C>A	c.(463-465)ACC>AAC	p.T155N	TP53_uc002gig.1_Missense_Mutation_p.T155N|TP53_uc002gih.2_Missense_Mutation_p.T155N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.T23N|TP53_uc010cng.1_Missense_Mutation_p.T23N|TP53_uc002gii.1_Missense_Mutation_p.T23N|TP53_uc010cnh.1_Missense_Mutation_p.T155N|TP53_uc010cni.1_Missense_Mutation_p.T155N|TP53_uc002gij.2_Missense_Mutation_p.T155N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.T62N|TP53_uc002gio.2_Missense_Mutation_p.T23N|TP53_uc010vug.1_Missense_Mutation_p.T116N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	155	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|T -> S (in sporadic cancers; somatic mutation).|T -> P (in sporadic cancers; somatic mutation).|T -> A (in sporadic cancers; somatic mutation).|T -> I (in sporadic cancers; somatic mutation).|T -> M (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T155N(19)|p.T155P(14)|p.T155I(10)|p.0?(7)|p.T155A(7)|p.T155T(5)|p.P152fs*14(3)|p.G154fs*14(2)|p.T155fs*23(2)|p.P153fs*22(2)|p.T155S(2)|p.P151_V173del23(1)|p.G154_R156delGTR(1)|p.T155fs*26(1)|p.T155fs*25(1)|p.R156_A161del(1)|p.D148_T155delDSTPPPGT(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.T155fs*15(1)|p.R156fs*25(1)|p.T155_R156delTR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGGACGCGGGTGCCGGGCGG	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578466	T	T	7578466	3	4	77	1	0	0	0	0	1	0	0	0	16378	1261	44	5	834	5	TP53	17	7578466	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	186	7578466	73616744	68	5225											
ODF4	146852	broad.mit.edu	37	chr17	8243550	8243550	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaacaggtccttgggccagCgccagaactctccgctgccc	11	16	1	1	rs147153349		TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr17:8243550C>T	uc002gle.1	+	1	363	c.181C>T	c.(181-183)CGC>TGC	p.R61C		NM_153007	NP_694552	Q2M2E3	ODFP4_HUMAN	outer dense fiber of sperm tails 4	61					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)	1						CTTGGGCCAGCGCCAGAACTC	0.592													T	8243550	T	T	8243550	3	4	77	1	0	0	0	0	1	0	0	0	10833	768	27	1	183	1	ODF4	17	8243550	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	665084	8243550	72951660	69	5226											
MYH13	8735	broad.mit.edu	37	chr17	10213133	10213133	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcaagatcttgctctcctcGtgttccaaggaaccctgacg	9	14	2	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr17:10213133G>A	uc002gmk.1	-	34	4761	c.4671C>T	c.(4669-4671)CAC>CAT	p.H1557H		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1557	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGCTCTCCTCGTGTTCCAAGG	0.498													A	10213133	A	A	10213133	2	1	77	1	0	0	0	0	0	0	0	1	10032	1136	40	1		1	MYH13	17	10213133	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08	1969583	10213133	70982077	70	5227											
KRT27	342574	broad.mit.edu	37	chr17	38936090	38936090	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgttcacgttgcctccagcCgcgcactgaagagctttcat	9	14	2	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr17:38936090C>T	uc002hvg.2	-	4	749	c.708G>A	c.(706-708)GCG>GCA	p.A236A		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	236	Rod.|Linker 12.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				TGCCTCCAGCCGCGCACTGAA	0.433													T	38936090	T	T	38936090	2	4	77	1	0	0	0	0	0	0	0	1	8464	639	23	2		2	KRT27	17	38936090	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	28722957	38936090	42259120	71	5228											
SEPT4	5414	broad.mit.edu	37	chr17	56599396	56599396	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tcttggatgttctttcggttCaggccactctcgtctcggaa	10	11	5	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr17:56599396C>A	uc002iwm.1	-	6	857	c.729G>T	c.(727-729)CTG>CTT	p.L243L	SEPT4_uc002iwk.1_Silent_p.L96L|SEPT4_uc010wnw.1_Silent_p.L96L|SEPT4_uc002iwl.1_Silent_p.L96L|SEPT4_uc002iwn.1_Silent_p.L144L|SEPT4_uc002iwo.1_Silent_p.L224L|SEPT4_uc002iwp.1_Silent_p.L224L|SEPT4_uc010wnx.1_Silent_p.L258L|SEPT4_uc010wny.1_Silent_p.L235L|SEPT4_uc010dcy.1_Silent_p.L125L	NM_004574	NP_004565	O43236	SEPT4_HUMAN	septin 4 isoform 1	243					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCTTTCGGTTCAGGCCACTCT	0.542													A	56599396	A	A	56599396	2	1	77	1	0	0	0	0	0	0	0	1	14066	813	29	5		5	SEPT4	17	56599396	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	17663306	56599396	24595814	72	5229											
C17orf71	55181	broad.mit.edu	37	chr17	57290240	57290240	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttaaagaaaaagaacctcaaAcccaaggagagagcacgagc	9	9	1	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr17:57290240A>G	uc002ixi.2	+	3	2098	c.2056A>G	c.(2056-2058)ACC>GCC	p.T686A		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	686					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					AGAACCTCAAACCCAAGGAGA	0.453													G	57290240	G	G	57290240	3	3	77	1	0	0	0	0	1	0	0	0	1878	43	2	4	2066	4	C17orf71	17	57290240	Missense_Mutation	SNP	A	TCGA-06-2559-01A-01D-1494-08	690844	57290240	23904970	73	5230											
CASKIN2	57513	broad.mit.edu	37	chr17	73498060	73498062	+	In_Frame_Del	DEL	GGA	-	-													gctggggaaggctagaagctGgaggagactcgccaggagtt					rs150879399		TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr17:73498060_73498062delGGA	uc002joc.2	-	18	3643_3645	c.3093_3095delTCC	c.(3091-3096)CCTCCA>CCA	p.1031_1032PP>P	CASKIN2_uc010wsc.1_In_Frame_Del_p.949_950PP>P	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	1031_1032	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTAGAAGCTGGAGGAGACTCGC	0.69													-	73498062	-	-	73498060	7	5	77	1	0	1	0	1	0	0	0	0	2667	1348	47	0	525	0	CASKIN2	17	73498060	In_Frame_Del	DEL	GGA	TCGA-06-2559-01A-01D-1494-08	16207820	73498060	7697150	74	5231											
PTPRS	5802	broad.mit.edu	37	chr19	5221107	5221107	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgggcttgccgttgagcaggTtgaaggcagtccaggcggtg	18	8	0	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr19:5221107T>C	uc002mbv.2	-	20	3593	c.3359A>G	c.(3358-3360)AAC>AGC	p.N1120S	PTPRS_uc002mbu.1_Missense_Mutation_p.N689S|PTPRS_uc010xin.1_Missense_Mutation_p.N689S|PTPRS_uc002mbw.2_Missense_Mutation_p.N1098S|PTPRS_uc002mbx.2_Missense_Mutation_p.N693S|PTPRS_uc002mby.2_Missense_Mutation_p.N689S	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1120	Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GTTGAGCAGGTTGAAGGCAGT	0.622													C	5221107	C	C	5221107	3	2	77	1	0	0	0	0	1	0	0	0	12811	1725	60	4	2563	4	PTPRS	19	5221107	Missense_Mutation	SNP	T	TCGA-06-2559-01A-01D-1494-08		5221107	53907876	75	5232											
EMR1	2015	broad.mit.edu	37	chr19	6928180	6928180	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctgaatacagagacaggGttcatctggagtttcttggg	14	6	3	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr19:6928180G>A	uc002mfw.2	+	17	2285	c.2247G>A	c.(2245-2247)GGG>GGA	p.G749G	EMR1_uc010dvc.2_Silent_p.G684G|EMR1_uc010dvb.2_Silent_p.G697G|EMR1_uc010xji.1_Silent_p.G608G|EMR1_uc010xjj.1_Silent_p.G572G	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	749	Helical; Name=5; (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					CAGAGACAGGGTTCATCTGGA	0.498													A	6928180	A	A	6928180	2	1	77	1	0	0	0	0	0	0	0	1	5104	1248	44	3		3	EMR1	19	6928180	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08	1707073	6928180	52200803	76	5233											
ZNF333	84449	broad.mit.edu	37	chr19	14829286	14829286	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatacagctctgaccttatcAggcatgagaagactcatact	8	10	3	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr19:14829286A>G	uc002mzn.2	+	12	1281	c.1147A>G	c.(1147-1149)AGG>GGG	p.R383G	ZNF333_uc002mzk.3_Missense_Mutation_p.R274G	NM_032433	NP_115809	Q96JL9	ZN333_HUMAN	zinc finger protein 333	383	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGACCTTATCAGGCATGAGAA	0.453													G	14829286	G	G	14829286	3	3	77	1	0	0	0	0	1	0	0	0	17847	179	7	4	1189	4	ZNF333	19	14829286	Missense_Mutation	SNP	A	TCGA-06-2559-01A-01D-1494-08	7901106	14829286	44299697	77	5234											
OR7A17	26333	broad.mit.edu	37	chr19	14991924	14991924	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgtctggatgttaatgaGcatctttgggattgtagtgg	14	4	2	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr19:14991924G>A	uc010xob.1	-	1	244	c.244C>T	c.(244-246)CTC>TTC	p.L82F		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					ATGTTAATGAGCATCTTTGGG	0.473													A	14991924	A	A	14991924	3	1	77	1	0	0	0	0	1	0	0	0	11215	971	34	3	687	3	OR7A17	19	14991924	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	162638	14991924	44137059	78	5235											
PSG5	5673	broad.mit.edu	37	chr19	43679606	43679606	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaatgaagggtaaatgctgGggaggtctggaccatctgga	16	5	2	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr19:43679606G>A	uc002ovu.2	-	4	856	c.725C>T	c.(724-726)CCC>CTC	p.P242L	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.P117L|PSG5_uc002ovx.2_Missense_Mutation_p.P242L|PSG5_uc002ovv.2_Missense_Mutation_p.P335L|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	242	Ig-like C2-type 2.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				GTAAATGCTGGGGAGGTCTGG	0.498													A	43679606	A	A	43679606	3	1	77	1	0	0	0	0	1	0	0	0	12658	1232	43	3	290	3	PSG5	19	43679606	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	28687682	43679606	15449377	79	5236											
LENG8	114823	broad.mit.edu	37	chr19	54969780	54969780	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctcagaccagctcctggcCgcaggcctcccccagccccc	8	24	1	1			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr19:54969780C>T	uc002qfv.1	+	14	2353	c.2209C>T	c.(2209-2211)CGC>TGC	p.R737C	LENG8_uc002qfw.2_Intron			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		AGCTCCTGGCCGCAGGCCTCC	0.602													T	54969780	T	T	54969780	3	4	77	1	0	0	0	0	1	0	0	0	8724	667	23	2		2	LENG8	19	54969780	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	11290174	54969780	4159203	80	5237											
KIR2DL4	3805	broad.mit.edu	37	chr19	55316286	55316286	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgctctgcctggcccagcGctgtggtgcctcaaggagga	14	13	3	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr19:55316286G>A	uc010yfm.1	+	3	155	c.115G>A	c.(115-117)GCT>ACT	p.A39T	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_Missense_Mutation_p.A34T|KIR2DL4_uc002qhg.2_Missense_Mutation_p.A39T|KIR2DL4_uc002qhi.2_Missense_Mutation_p.A39T|KIR2DL4_uc002qhh.2_Intron|KIR2DL4_uc002qhj.2_Missense_Mutation_p.A39T|KIR2DL4_uc002qhf.2_Intron|KIR2DL4_uc010esd.2_Missense_Mutation_p.A39T|KIR2DL4_uc010ese.2_5'Flank	NM_002255	NP_002246	Q99706	KI2L4_HUMAN	killer cell immunoglobulin-like receptor, two	39	Extracellular (Potential).				cellular defense response|regulation of immune response	integral to plasma membrane	protein binding|transmembrane receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0192)		CTGGCCCAGCGCTGTGGTGCC	0.582													A	55316286	A	A	55316286	3	1	77	1	0	0	0	0	1	0	0	0	8318	1087	38	1	125	1	KIR2DL4	19	55316286	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	346506	55316286	3812697	81	5238											
NLRP4	147945	broad.mit.edu	37	chr19	56369522	56369522	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggtgacttgatggagaaaCggccggtgcaggtgcttctg	17	7	1	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr19:56369522C>T	uc002qmd.3	+	3	1185	c.763C>T	c.(763-765)CGG>TGG	p.R255W	NLRP4_uc002qmf.2_Missense_Mutation_p.R180W|NLRP4_uc010etf.2_Missense_Mutation_p.R86W	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	255	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GATGGAGAAACGGCCGGTGCA	0.577													T	56369522	T	T	56369522	3	4	77	1	0	0	0	0	1	0	0	0	10479	527	19	1	769	1	NLRP4	19	56369522	Missense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08	1053236	56369522	2759461	82	5239											
MAPK1	5594	broad.mit.edu	37	chr22	22142672	22142672	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttcttgtgatggggatccaaGaatacctatcagataaaaaa	8	6	2	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr22:22142672G>A	uc002zvn.2	-	6	970	c.730C>T	c.(730-732)CTT>TTT	p.L244F	MAPK1_uc002zvo.2_Missense_Mutation_p.L244F|MAPK1_uc010gtk.1_Intron	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	244	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	GGGGATCCAAGAATACCTATC	0.353													A	22142672	A	A	22142672	3	1	77	1	0	0	0	0	1	0	0	0	9271	942	33	3	364	3	MAPK1	22	22142672	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08		22142672	29161894	83	5240											
IL2RB	3560	broad.mit.edu	37	chr22	37524496	37524496	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctggggccaccgaggagactGggggagaagagcagcaggtc	19	9	0	3	rs143704470		TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chr22:37524496G>T	uc003aqv.1	-	10	1427	c.1296C>A	c.(1294-1296)CCC>CCA	p.P432P		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	432	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	CGAGGAGACTGGGGGAGAAGA	0.662													T	37524496	T	T	37524496	2	4	77	1	0	0	0	0	0	0	0	1	7687	1335	47	5		5	IL2RB	22	37524496	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08	15381824	37524496	13780070	84	5241											
BCOR	54880	broad.mit.edu	37	chrX	39923055	39923055	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgccgacacctgctgctccCatcgttctctaaggtgcagc	9	16	1	0			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chrX:39923055C>T	uc004den.3	-	8	3945	c.3653G>A	c.(3652-3654)TGG>TAG	p.W1218*	BCOR_uc004dep.3_Nonsense_Mutation_p.W1184*|BCOR_uc004deo.3_Nonsense_Mutation_p.W1166*|BCOR_uc010nhb.2_5'Flank|BCOR_uc004dem.3_Nonsense_Mutation_p.W1184*	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1218					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CTGCTGCTCCCATCGTTCTCT	0.542													T	39923055	T	T	39923055	4	4	77	1	0	0	0	0	0	1	0	0	1386	595	21	3	1646	3	BCOR	23	39923055	Nonsense_Mutation	SNP	C	TCGA-06-2559-01A-01D-1494-08		39923055	115347505	85	5242											
TAF1	6872	broad.mit.edu	37	chrX	70680612	70680612	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgatgtcctatgagggagaCggtggggaggcttcccatgg	17	7	0	3			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chrX:70680612C>T	uc004dzu.3	+	37	5406	c.5355C>T	c.(5353-5355)GAC>GAT	p.D1785D	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Silent_p.D1806D|TAF1_uc004dzv.3_Silent_p.D993D|TAF1_uc010nle.1_RNA|TAF1_uc010nlf.1_Silent_p.D210D|TAF1_uc004dzx.2_RNA|TAF1_uc004dzy.2_RNA|TAF1_uc004dzw.1_RNA|TAF1_uc010nlg.1_RNA	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1785	Asp/Glu-rich (acidic tail).|Protein kinase 2.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				ATGAGGGAGACGGTGGGGAGG	0.507													T	70680612	T	T	70680612	2	4	77	1	0	0	0	0	0	0	0	1	15510	535	19	1		1	TAF1	23	70680612	Silent	SNP	C	TCGA-06-2559-01A-01D-1494-08	30757557	70680612	84589948	86	5243											
CYLC1	1538	broad.mit.edu	37	chrX	83128394	83128394	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaaagaaagatttgaagagGtcaaagactagtaatgatcc	9	6	1	6			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chrX:83128394G>A	uc004eei.1	+	4	699	c.678G>A	c.(676-678)AGG>AGA	p.R226R	CYLC1_uc004eeh.1_Silent_p.R225R	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	226					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						ATTTGAAGAGGTCAAAGACTA	0.318													A	83128394	A	A	83128394	2	1	77	1	0	0	0	0	0	0	0	1	4141	1252	44	3		3	CYLC1	23	83128394	Silent	SNP	G	TCGA-06-2559-01A-01D-1494-08	12447782	83128394	72142166	87	5244											
PCDH11X	27328	broad.mit.edu	37	chrX	91132792	91132792	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaattcagcctggattgtcGtacaggcatgctgactgtag	12	8	1	2			TCGA-06-2559-01A-01D-1494-08	TCGA-06-2559-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8df5560b-9f8f-4636-bdb2-1af8b45df1ba	3b989d83-d6cc-41a8-bf7b-b3e50adb99ea	g.chrX:91132792G>A	uc004efk.1	+	2	2398	c.1553G>A	c.(1552-1554)CGT>CAT	p.R518H	PCDH11X_uc004efl.1_Missense_Mutation_p.R518H|PCDH11X_uc004efo.1_Missense_Mutation_p.R518H|PCDH11X_uc010nmv.1_Missense_Mutation_p.R518H|PCDH11X_uc004efm.1_Missense_Mutation_p.R518H|PCDH11X_uc004efn.1_Missense_Mutation_p.R518H|PCDH11X_uc004efh.1_Missense_Mutation_p.R518H|PCDH11X_uc004efj.1_Missense_Mutation_p.R518H	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	518	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTGGATTGTCGTACAGGCATG	0.433													A	91132792	A	A	91132792	3	1	77	1	0	0	0	0	1	0	0	0	11508	1145	40	1	1559	1	PCDH11X	23	91132792	Missense_Mutation	SNP	G	TCGA-06-2559-01A-01D-1494-08	8004398	91132792	64137768	88	5245											
PUM1	9698	broad.mit.edu	37	chr1	31409615	31409615	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggaccgtcgttcatggtgcAcacctcatcgatgagcacag	12	12	2	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr1:31409615A>C	uc001bsi.1	-	21	3417	c.3304T>G	c.(3304-3306)TGC>GGC	p.C1102G	PUM1_uc001bsf.1_Missense_Mutation_p.C770G|PUM1_uc001bsg.1_Missense_Mutation_p.C836G|PUM1_uc001bsh.1_Missense_Mutation_p.C1104G|PUM1_uc001bsj.1_Missense_Mutation_p.C1078G|PUM1_uc010oga.1_Missense_Mutation_p.C960G|PUM1_uc001bsk.1_Missense_Mutation_p.C1140G|PUM1_uc010ogb.1_Missense_Mutation_p.C1043G|SNORD103A_uc009vts.1_Intron	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	1102	PUM-HD.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TTCATGGTGCACACCTCATCG	0.522													C	31409615	C	C	31409615	3	2	78	1	0	0	0	0	1	0	0	0	12825	159	6	5	264	5	PUM1	1	31409615	Missense_Mutation	SNP	A	TCGA-06-2561-01A-02D-1494-08		31409615	217841006	1	5246											
SOAT1	6646	broad.mit.edu	37	chr1	179304764	179304764	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tcacaaccttttctgttcttGaaggagagaaaaacaaccat	6	9	3	2			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr1:179304764G>A	uc001gml.2	+	4	364	c.301G>A	c.(301-303)GAA>AAA	p.E101K	SOAT1_uc010pni.1_Missense_Mutation_p.E36K|SOAT1_uc001gmm.2_Missense_Mutation_p.E43K|SOAT1_uc010pnj.1_5'UTR|SOAT1_uc010pnk.1_Missense_Mutation_p.E36K	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	101					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	TTCTGTTCTTGAAGGAGAGAA	0.318													A	179304764	A	A	179304764	3	1	78	1	0	0	0	0	1	0	0	0	14910	1291	45	3	311	3	SOAT1	1	179304764	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	147895149	179304764	69945857	2	5247			1	17		2	2	30	G		4.496495e-05
SOAT1	6646	broad.mit.edu	37	chr1	179304793	179304793	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaaaacaaccatagagcgaaGtaagtatgtgctattttctt	7	6	1	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr1:179304793G>C	uc001gml.2	+	4	392	c.329_splice	c.e4+1	p.K110_splice	SOAT1_uc010pni.1_Splice_Site_p.K45_splice|SOAT1_uc001gmm.2_Splice_Site_p.K52_splice|SOAT1_uc010pnj.1_Splice_Site|SOAT1_uc010pnk.1_Splice_Site_p.K45_splice	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1						cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	ATAGAGCGAAGTAAGTATGTG	0.259													C	179304793	C	C	179304793	5	2	78	1	0	0	0	0	0	0	1	0	14910	1043	36	5	340	5	SOAT1	1	179304793	Splice_Site	SNP	G	TCGA-06-2561-01A-02D-1494-08	29	179304793	69945828	3	5248			1	17		2	2	30	G		4.496495e-05
KCNT2	343450	broad.mit.edu	37	chr1	196398829	196398829	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgtcacaatgcagaaataaaGggagtcaaagagattcagct	10	7	3	2			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr1:196398829G>T	uc001gtd.1	-	9	757	c.697C>A	c.(697-699)CTT>ATT	p.L233I	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.L233I|KCNT2_uc001gtf.1_Missense_Mutation_p.L233I|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.L233I|KCNT2_uc009wyv.1_Missense_Mutation_p.L208I	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	233						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CAGAAATAAAGGGAGTCAAAG	0.393													T	196398829	T	T	196398829	3	4	78	1	0	0	0	0	1	0	0	0	8092	1000	35	5	2790	5	KCNT2	1	196398829	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	17094036	196398829	52851792	4	5249											
BCL11A	53335	broad.mit.edu	37	chr2	60679781	60679781	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agctctctgggtactacgccGaatgggggtgtgtgaagaac	15	8	1	2			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr2:60679781G>A	uc002sab.2	-	5	2479	c.2251C>T	c.(2251-2253)CGG>TGG	p.R751W	BCL11A_uc002sac.2_Silent_p.F217F|BCL11A_uc010ypi.1_Missense_Mutation_p.R420W|BCL11A_uc010ypj.1_Silent_p.F767F	NM_018014	NP_060484	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 2	Error:Variant_position_missing_in_Q9H165_after_alignment					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GTACTACGCCGAATGGGGGTG	0.498			T	IGH@	B-CLL								A	60679781	A	A	60679781	3	1	78	1	0	0	0	0	1	0	0	0	1363	1058	37	2	84	2	BCL11A	2	60679781	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08		60679781	182519592	5	5250											
ALMS1	7840	broad.mit.edu	37	chr2	73717955	73717955	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctcaaggtcaggattctataGcttcagaccttccgtctccc	7	14	5	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr2:73717955G>C	uc002sje.1	+	12	8983	c.8872G>C	c.(8872-8874)GCT>CCT	p.A2958P	ALMS1_uc002sjf.1_Missense_Mutation_p.A2914P|ALMS1_uc002sjg.2_Missense_Mutation_p.A2344P|ALMS1_uc002sjh.1_Missense_Mutation_p.A2344P	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2956					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GGATTCTATAGCTTCAGACCT	0.438													C	73717955	C	C	73717955	3	2	78	1	0	0	0	0	1	0	0	0	535	971	34	5	8904	5	ALMS1	2	73717955	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	13038174	73717955	169481418	6	5251			2	18		2	2	31	G		4.651543e-05
ALMS1	7840	broad.mit.edu	37	chr2	73717985	73717985	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttccgtctcccatttctcttGaacaatgccaaagcaaagcg	6	13	2	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr2:73717985G>C	uc002sje.1	+	12	9013	c.8902G>C	c.(8902-8904)GAA>CAA	p.E2968Q	ALMS1_uc002sjf.1_Missense_Mutation_p.E2924Q|ALMS1_uc002sjg.2_Missense_Mutation_p.E2354Q|ALMS1_uc002sjh.1_Missense_Mutation_p.E2354Q	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2966					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CATTTCTCTTGAACAATGCCA	0.428													C	73717985	C	C	73717985	3	2	78	1	0	0	0	0	1	0	0	0	535	1291	45	5	8934	5	ALMS1	2	73717985	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	30	73717985	169481388	7	5252			2	18		2	2	31	G		4.651543e-05
TTN	7273	broad.mit.edu	37	chr2	179623871	179623871	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgagatggcttgattttcttGtctttgctgtaccacgacac	9	10	2	2			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr2:179623871G>T	uc010zfg.1	-	44	10367	c.10143C>A	c.(10141-10143)GAC>GAA	p.D3381E	TTN_uc010zfh.1_Missense_Mutation_p.D3335E|TTN_uc010zfi.1_Missense_Mutation_p.D3335E|TTN_uc010zfj.1_Missense_Mutation_p.D3335E|TTN_uc002umz.1_Missense_Mutation_p.D42E|TTN_uc002unb.2_Missense_Mutation_p.D3381E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATTTTCTTGTCTTTGCTGT	0.368													T	179623871	T	T	179623871	3	4	78	1	0	0	0	0	1	0	0	0	16732	1368	48	5	101121	5	TTN	2	179623871	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	105905886	179623871	63575502	8	5253											
AOX1	316	broad.mit.edu	37	chr2	201527627	201527627	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaggcgaaggccagcccttcGaatactttgtttatggagct	11	9	0	0	rs142723794	byFrequency	TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr2:201527627G>A	uc002uvx.2	+	31	3579	c.3478G>A	c.(3478-3480)GAA>AAA	p.E1160K	AOX1_uc010zhf.1_Missense_Mutation_p.E716K|AOX1_uc010fsu.2_Missense_Mutation_p.E526K	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	1160					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CCAGCCCTTCGAATACTTTGT	0.483													A	201527627	A	A	201527627	3	1	78	1	0	0	0	0	1	0	0	0	729	1059	37	2	3600	2	AOX1	2	201527627	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	21903756	201527627	41671746	9	5254											
CREB1	1385	broad.mit.edu	37	chr2	208434967	208434971	+	Frame_Shift_Del	DEL	GAAGA	-	-													ggattgaagaagagaagtctGaagaggagacttcagcacct							TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr2:208434967_208434971delGAAGA	uc002vcc.2	+	6	720_724	c.469_473delGAAGA	c.(469-474)GAAGAGfs	p.E157fs	CREB1_uc010ziz.1_Frame_Shift_Del_p.E141fs|CREB1_uc002vcd.2_Frame_Shift_Del_p.E143fs|CREB1_uc010zja.1_RNA	NM_134442	NP_604391	P16220	CREB1_HUMAN	cAMP responsive element binding protein 1	157_158	KID.				activation of phospholipase C activity|axon guidance|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein dimerization activity|transcription cofactor activity		EWSR1/CREB1(42)	soft_tissue(42)|breast(1)|central_nervous_system(1)	44				LUSC - Lung squamous cell carcinoma(261;0.0768)|Epithelial(149;0.127)|Lung(261;0.145)	Adenosine monophosphate(DB00131)|Bromocriptine(DB01200)|Naloxone(DB01183)	AGAGAAGTCTGAAGAGGAGACTTCA	0.371			T	EWSR1	clear cell sarcoma|angiomatoid fibrous histiocytoma								-	208434971	-	-	208434967	7	5	78	1	0	1	0	1	0	0	0	0	3854	1291	45	0	487	0	CREB1	2	208434967	Frame_Shift_Del	DEL	GAAGA	TCGA-06-2561-01A-02D-1494-08	6907340	208434967	34764406	10	5255											
XRCC5	7520	broad.mit.edu	37	chr2	216995664	216995664	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggaacaaatgaaatataaatCggaggggaagtgcttctctg	12	5	1	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr2:216995664C>T	uc002vfy.2	+	9	1144	c.1004C>T	c.(1003-1005)TCG>TTG	p.S335L	XRCC5_uc002vfz.2_Missense_Mutation_p.S221L	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	335	Ku.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		AAATATAAATCGGAGGGGAAG	0.368								Direct_reversal_of_damage|NHEJ					T	216995664	T	T	216995664	3	4	78	1	0	0	0	0	1	0	0	0	17453	893	31	2	1038	2	XRCC5	2	216995664	Missense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08	8560697	216995664	26203709	11	5256											
SRGAP3	9901	broad.mit.edu	37	chr3	9055068	9055068	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggggctggggaagatggcttCatgatggatgatgatggttt	18	3	1	4			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr3:9055068C>A	uc003brf.1	-	17	2747	c.2071G>T	c.(2071-2073)GAA>TAA	p.E691*	SRGAP3_uc003brg.1_Nonsense_Mutation_p.E667*	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	691					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		AAGATGGCTTCATGATGGATG	0.512			T	RAF1	pilocytic astrocytoma								A	9055068	A	A	9055068	4	1	78	1	0	0	0	0	0	1	0	0	15146	835	29	5	1252	5	SRGAP3	3	9055068	Nonsense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08		9055068	188967362	12	5257											
FANCD2	2177	broad.mit.edu	37	chr3	10107617	10107617	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	catgtctgctaaagagcgttCattcatgtgttctctcatat	7	9	5	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr3:10107617C>T	uc003buw.2	+	25	2417	c.2339C>T	c.(2338-2340)TCA>TTA	p.S780L	FANCD2_uc003bux.1_Missense_Mutation_p.S780L|FANCD2_uc003buy.1_Missense_Mutation_p.S780L|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	780					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AAAGAGCGTTCATTCATGTGT	0.403			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				T	10107617	T	T	10107617	3	4	78	1	0	0	0	0	1	0	0	0	5665	838	29	3	2433	3	FANCD2	3	10107617	Missense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08	1052549	10107617	187914813	13	5258											
KIAA1211	57482	broad.mit.edu	37	chr4	57189557	57189557	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ccacagagaagccgatgcttCagagcagacactccttagat	9	12	1	4			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr4:57189557C>T	uc003hbk.2	+	9	3593	c.3202C>T	c.(3202-3204)CAG>TAG	p.Q1068*	KIAA1211_uc010iha.2_Nonsense_Mutation_p.Q1061*	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	1068										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCCGATGCTTCAGAGCAGACA	0.468													T	57189557	T	T	57189557	4	4	78	1	0	0	0	0	0	1	0	0	8215	827	29	3	3224	3	KIAA1211	4	57189557	Nonsense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08		57189557	133964719	14	5259											
ALB	213	broad.mit.edu	37	chr4	74283255	74283255	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttctttttttcaggctattaGttcgttacaccaagaaagta	6	7	2	1	rs141626688		TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr4:74283255G>T	uc003hgs.3	+	11	1370	c.1297G>T	c.(1297-1299)GTT>TTT	p.V433F	ALB_uc003hgw.3_Missense_Mutation_p.V241F|ALB_uc011cbe.1_Missense_Mutation_p.V112F|ALB_uc003hgt.3_Missense_Mutation_p.V433F|ALB_uc010iii.2_Missense_Mutation_p.V318F|ALB_uc003hgu.3_Missense_Mutation_p.V283F|ALB_uc003hgv.3_Missense_Mutation_p.V112F|ALB_uc011cbf.1_Missense_Mutation_p.V323F|ALB_uc010iij.2_Intron|ALB_uc003hgx.3_Missense_Mutation_p.V112F	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	433	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CAGGCTATTAGTTCGTTACAC	0.398													T	74283255	T	T	74283255	3	4	78	1	0	0	0	0	1	0	0	0	486	1029	36	5	1339	5	ALB	4	74283255	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	17093698	74283255	116871021	15	5260											
ATP10B	23120	broad.mit.edu	37	chr5	160063304	160063304	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttcttcaaaggtcccattcCagatgctgtgacctgagagg	11	10	2	3			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr5:160063304C>T	uc003lym.1	-	11	1860	c.1013G>A	c.(1012-1014)TGG>TAG	p.W338*	ATP10B_uc003lyp.2_Nonsense_Mutation_p.W338*|ATP10B_uc011deg.1_Nonsense_Mutation_p.W382*|ATP10B_uc003lyn.2_5'Flank|ATP10B_uc003lyo.2_Nonsense_Mutation_p.W310*	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	338	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGTCCCATTCCAGATGCTGTG	0.498													T	160063304	T	T	160063304	4	4	78	1	0	0	0	0	0	1	0	0	1117	595	21	3	3436	3	ATP10B	5	160063304	Nonsense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08		160063304	20851956	16	5261											
CLIC5	53405	broad.mit.edu	37	chr6	45882089	45882089	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgtcaatctcctctggtagaGgggtgttcaggtagtcatcc	12	10	5	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr6:45882089G>C	uc003oxv.3	-	5	1047	c.941C>G	c.(940-942)CCT>CGT	p.P314R	CLIC5_uc003oxu.3_Missense_Mutation_p.P155R|CLIC5_uc003oxw.2_RNA|CLIC5_uc003oxx.2_Missense_Mutation_p.P155R	NM_001114086	NP_001107558	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5 isoform a	314	GST C-terminal.				female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			ovary(1)|skin(1)	2						CTCTGGTAGAGGGGTGTTCAG	0.512													C	45882089	C	C	45882089	3	2	78	1	0	0	0	0	1	0	0	0	3529	1000	35	5	299	5	CLIC5	6	45882089	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08		45882089	125232978	17	5262											
SNAP91	9892	broad.mit.edu	37	chr6	84284736	84284736	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattgctacataccaaaggtGcacttggtggaacgcctgct	11	10	0	0			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr6:84284736G>A	uc011dze.1	-	25	2752	c.2435C>T	c.(2434-2436)GCA>GTA	p.A812V	SNAP91_uc011dzd.1_Missense_Mutation_p.A310V|SNAP91_uc003pkb.2_Missense_Mutation_p.A721V|SNAP91_uc003pkc.2_Missense_Mutation_p.A782V|SNAP91_uc003pkd.2_Missense_Mutation_p.A505V|SNAP91_uc003pka.2_Missense_Mutation_p.A810V	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	812	Pro-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TACCAAAGGTGCACTTGGTGG	0.522													A	84284736	A	A	84284736	3	1	78	1	0	0	0	0	1	0	0	0	14833	1319	46	3	304	3	SNAP91	6	84284736	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	38402647	84284736	86830331	18	5263											
EGFR	1956	broad.mit.edu	37	chr7	55214319	55214319	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatcctgcatggcgccgtgCggttcagcaacaaccctgcc	10	15	1	0			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr7:55214319C>T	uc003tqk.2	+	4	691	c.445C>T	c.(445-447)CGG>TGG	p.R149W	EGFR_uc003tqh.2_Missense_Mutation_p.R149W|EGFR_uc003tqi.2_Missense_Mutation_p.R149W|EGFR_uc003tqj.2_Missense_Mutation_p.R149W|EGFR_uc010kzg.1_Intron|EGFR_uc011kco.1_Missense_Mutation_p.R96W	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	149	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGGCGCCGTGCGGTTCAGCAA	0.532		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55214319	T	T	55214319	3	4	78	1	0	0	0	0	1	0	0	0	4967	759	27	1	459	1	EGFR	7	55214319	Missense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08		55214319	103924344	19	5264											
PIK3CG	5294	broad.mit.edu	37	chr7	106508473	106508473	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttccagcggcagctcacggCgctgattggctatgacgtca	12	13	2	2			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr7:106508473C>T	uc003vdv.3	+	2	552	c.467C>T	c.(466-468)GCG>GTG	p.A156V	PIK3CG_uc003vdu.2_Missense_Mutation_p.A156V|PIK3CG_uc003vdw.2_Missense_Mutation_p.A156V	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	156					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CAGCTCACGGCGCTGATTGGC	0.682													T	106508473	T	T	106508473	3	4	78	1	0	0	0	0	1	0	0	0	11916	768	27	1	469	1	PIK3CG	7	106508473	Missense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08	51294154	106508473	52630190	20	5265											
POLR3D	661	broad.mit.edu	37	chr8	22106786	22106786	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagaggtgcagggcgaggaCggacaggtggtgctcatcaa	17	8	2	1	rs139222181	byFrequency	TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr8:22106786C>T	uc003xbl.2	+	7	968	c.885C>T	c.(883-885)GAC>GAT	p.D295D	POLR3D_uc003xbm.2_Silent_p.D295D|POLR3D_uc011kze.1_Intron	NM_001722	NP_001713	P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	295					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity				0				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		AGGGCGAGGACGGACAGGTGG	0.597													T	22106786	T	T	22106786	2	4	78	1	0	0	0	0	0	0	0	1	12231	535	19	1		1	POLR3D	8	22106786	Silent	SNP	C	TCGA-06-2561-01A-02D-1494-08		22106786	124257236	21	5266											
MLLT3	4300	broad.mit.edu	37	chr9	20448206	20448206	+	Frame_Shift_Del	DEL	G	-	-													agcggaggtgattcactggtGgatggccttcaagatgcagg							TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr9:20448206delG	uc003zoe.2	-	4	594	c.335delC	c.(334-336)CCAfs	p.P112fs	MLLT3_uc011lne.1_Frame_Shift_Del_p.P80fs|MLLT3_uc011lnf.1_Frame_Shift_Del_p.P109fs|MLLT3_uc003zof.2_Intron|MLLT3_uc011lng.1_Frame_Shift_Del_p.P80fs	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	112	YEATS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		ATTCACTGGTGGATGGCCTTC	0.448			T	MLL	ALL								-	20448206	-	-	20448206	7	5	78	1	0	1	0	1	0	0	0	0	9628	1348	47	0	1403	0	MLLT3	9	20448206	Frame_Shift_Del	DEL	G	TCGA-06-2561-01A-02D-1494-08		20448206	120765225	22	5267											
OR1B1	347169	broad.mit.edu	37	chr9	125391091	125391091	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacaggtggagactgctcGgcggcgaccagcagctgaag	15	12	0	2			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr9:125391091G>A	uc011lyz.1	-	1	724	c.724C>T	c.(724-726)CGA>TGA	p.R242*		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	242	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAGACTGCTCGGCGGCGACCA	0.557													A	125391091	A	A	125391091	4	1	78	1	0	0	0	0	0	1	0	0	10951	1124	39	2	235	2	OR1B1	9	125391091	Nonsense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	104942885	125391091	15822340	23	5268											
CBARA1	10367	broad.mit.edu	37	chr10	74234889	74234889	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacatcatgctgcagtttaCgctgaaattcgaggaagttt	10	7	1	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr10:74234889C>T	uc001jtb.1	-	9	1041	c.908G>A	c.(907-909)CGT>CAT	p.R303H	CBARA1_uc010qjw.1_Missense_Mutation_p.R103H|CBARA1_uc010qjx.1_Missense_Mutation_p.R103H|CBARA1_uc009xqo.1_RNA	NM_006077	NP_006068	Q9BPX6	MICU1_HUMAN	calcium binding atopy-related autoantigen 1	301					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			ovary(1)	1						CTGCAGTTTACGCTGAAATTC	0.463													T	74234889	T	T	74234889	3	4	78	1	0	0	0	0	1	0	0	0	2696	536	19	1	548	1	CBARA1	10	74234889	Missense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08		74234889	61299858	24	5269											
PTEN	5728	broad.mit.edu	37	chr10	89720799	89720802	+	Frame_Shift_Del	DEL	TACT	-	-													taatgacaaggaatatctagTacttactttaacaaaaaatg							TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr10:89720799_89720802delTACT	uc001kfb.2	+	9	1981_1984	c.950_953delTACT	c.(949-954)GTACTTfs	p.V317fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	317_318	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.L318fs*2(17)|p.V317fs*3(16)|p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.V317fs*6(2)|p.G165_*404del(1)|p.G165_K342del(1)|p.L316fs*1(1)|p.W274_F341del(1)|p.V317_K322del(1)|p.L318F(1)|p.T318fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GAATATCTAGTACTTACTTTAACA	0.333	V317fs*3(SKUT1_SOFT_TISSUE)|V317fs*3(EVSAT_BREAST)|V317fs*3(IGROV1_OVARY)|V317fs*3(ISHIKAWAHERAKLIO02ER_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89720802	-	-	89720799	7	5	78	1	0	1	0	1	0	0	0	0	12738	1638	57	0	980	0	PTEN	10	89720799	Frame_Shift_Del	DEL	TACT	TCGA-06-2561-01A-02D-1494-08	15485910	89720799	45813948	25	5270											
MEN1	4221	broad.mit.edu	37	chr11	64575552	64575552	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accacagcaaaggccacaccGgagctgtccaatttggtgcc	10	14	0	0			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr11:64575552G>A	uc001obj.2	-	3	553	c.480C>T	c.(478-480)TCC>TCT	p.S160S	MEN1_uc001obk.2_Silent_p.S160S|MEN1_uc001obl.2_Silent_p.S155S|MEN1_uc001obm.2_Silent_p.S155S|MEN1_uc001obn.2_Silent_p.S160S|MEN1_uc001obo.2_Silent_p.S160S|MEN1_uc001obp.2_Silent_p.S155S|MEN1_uc001obq.2_Silent_p.S160S|MEN1_uc001obr.2_Silent_p.S160S	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	160			S -> F (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						AGGCCACACCGGAGCTGTCCA	0.602			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				A	64575552	A	A	64575552	2	1	78	1	0	0	0	0	0	0	0	1	9472	1103	39	2		2	MEN1	11	64575552	Silent	SNP	G	TCGA-06-2561-01A-02D-1494-08		64575552	70430964	26	5271											
MTNR1B	4544	broad.mit.edu	37	chr11	92715286	92715286	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agctacttactggcttatttCaacagctgcctgaatgccat	7	11	1	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr11:92715286C>T	uc001pdk.1	+	2	1000	c.897C>T	c.(895-897)TTC>TTT	p.F299F		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	299	Helical; Name=7; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	TGGCTTATTTCAACAGCTGCC	0.522													T	92715286	T	T	92715286	2	4	78	1	0	0	0	0	0	0	0	1	9952	825	29	3		3	MTNR1B	11	92715286	Silent	SNP	C	TCGA-06-2561-01A-02D-1494-08	28139734	92715286	42291230	27	5272											
KRAS	3845	broad.mit.edu	37	chr12	25398284	25398284	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcactcttgcctacgccaCcagctccaactaccacaagt	6	17	1	0	rs121913529		TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr12:25398284C>T	uc001rgp.1	-	2	216	c.35G>A	c.(34-36)GGT>GAT	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			T	25398284	T	T	25398284	3	4	78	1	0	0	0	0	1	0	0	0	8438	507	18	3	671	3	KRAS	12	25398284	Missense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08		25398284	108453611	28	5273											
ADCY6	112	broad.mit.edu	37	chr12	49169145	49169145	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggcgcacatggtccttccGcagctgatcaatgctgcggg	13	14	1	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr12:49169145G>A	uc001rsh.3	-	10	2581	c.1921C>T	c.(1921-1923)CGG>TGG	p.R641W	ADCY6_uc001rsj.3_Missense_Mutation_p.R641W|ADCY6_uc001rsi.3_Missense_Mutation_p.R641W|ADCY6_uc010slw.1_5'Flank	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	641	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						TGGTCCTTCCGCAGCTGATCA	0.597													A	49169145	A	A	49169145	3	1	78	1	0	0	0	0	1	0	0	0	298	1086	38	1	1633	1	ADCY6	12	49169145	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	23770861	49169145	84682750	29	5274											
SLC5A8	160728	broad.mit.edu	37	chr12	101555815	101555815	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agttccaacagtgctgaagtAcagatatgataaagaatacc	8	7	0	4			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr12:101555815A>G	uc001thz.3	-	13	1957	c.1567T>C	c.(1567-1569)TAC>CAC	p.Y523H		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	523	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						GTGCTGAAGTACAGATATGAT	0.358													G	101555815	G	G	101555815	3	3	78	1	0	0	0	0	1	0	0	0	14671	391	14	4	277	4	SLC5A8	12	101555815	Missense_Mutation	SNP	A	TCGA-06-2561-01A-02D-1494-08	52386670	101555815	32296080	30	5275											
DYX1C1	161582	broad.mit.edu	37	chr15	55790519	55790520	+	Frame_Shift_Del	DEL	AA	-	-													cagctgtaatcgctaacctgAagaggcattccggtagcaac							TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr15:55790519_55790520delAA	uc002adc.2	-	2	376_377	c.8_9delTT	c.(7-9)CTTfs	p.L3fs	CCPG1_uc002acy.2_5'UTR|DYX1C1_uc010ugh.1_RNA|DYX1C1_uc010ugi.1_RNA|DYX1C1_uc002adb.2_Frame_Shift_Del_p.L3fs|DYX1C1_uc002add.2_Frame_Shift_Del_p.L3fs	NM_130810	NP_570722	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1 isoform a	3	CS.				neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			skin(1)	1				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		CGCTAACCTGAAGAGGCATTCC	0.599													-	55790520	-	-	55790519	7	5	78	1	0	1	0	1	0	0	0	0	4862	233	9	0	1392	0	DYX1C1	15	55790519	Frame_Shift_Del	DEL	AA	TCGA-06-2561-01A-02D-1494-08		55790519	46740873	31	5276											
GOLGA6A	342096	broad.mit.edu	37	chr15	74365151	74365151	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctggtggctggcagcttctAggtgctcctaaggggacggg	17	9	2	0			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr15:74365151A>C	uc002axa.1	-	13	1474	c.1433T>G	c.(1432-1434)CTA>CGA	p.L478R		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	478	Potential.										0						GGCAGCTTCTAGGTGCTCCTA	0.612													C	74365151	C	C	74365151	3	2	78	1	0	0	0	0	1	0	0	0	6557	420	15	5	672	5	GOLGA6A	15	74365151	Missense_Mutation	SNP	A	TCGA-06-2561-01A-02D-1494-08	18574632	74365151	28166241	32	5277											
GOLGA6D	653643	broad.mit.edu	37	chr15	75580652	75580652	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	actccttacagcatattcaaGaattggagcgggctctctgt	9	10	2	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr15:75580652G>A	uc010uma.1	+	7	546	c.511G>A	c.(511-513)GAA>AAA	p.E171K	uc010umb.1_5'Flank	NM_001145224	NP_001138696	P0CG33	GOG6D_HUMAN	golgi autoantigen, golgin subfamily a, 6D	171	Potential.										0						GCATATTCAAGAATTGGAGCG	0.557													A	75580652	A	A	75580652	3	1	78	1	0	0	0	0	1	0	0	0	6560	943	33	3	537	3	GOLGA6D	15	75580652	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	1215501	75580652	26950740	33	5278											
TTLL13	440307	broad.mit.edu	37	chr15	90802040	90802040	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gaagtaaaggatgcacttctCtgtgatgctatgacccttgt	10	8	1	2			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr15:90802040C>T	uc002bpd.1	+	10	1521	c.1233C>T	c.(1231-1233)CTC>CTT	p.L411L	TTLL13_uc002bpe.1_RNA	NM_001029964	NP_001025135	A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	411	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			ATGCACTTCTCTGTGATGCTA	0.512													T	90802040	T	T	90802040	2	4	78	1	0	0	0	0	0	0	0	1	16723	900	32	3		3	TTLL13	15	90802040	Silent	SNP	C	TCGA-06-2561-01A-02D-1494-08	15221388	90802040	11729352	34	5279											
DNAH3	55567	broad.mit.edu	37	chr16	21145587	21145587	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agggacttcttactctgcaaAccacagttctttcagcctga	7	12	4	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr16:21145587A>G	uc010vbe.1	-	7	1075	c.1075T>C	c.(1075-1077)TTT>CTT	p.F359L	DNAH3_uc002die.2_Missense_Mutation_p.F330L	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	359	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TACTCTGCAAACCACAGTTCT	0.527													G	21145587	G	G	21145587	3	3	78	1	0	0	0	0	1	0	0	0	4603	43	2	4	11498	4	DNAH3	16	21145587	Missense_Mutation	SNP	A	TCGA-06-2561-01A-02D-1494-08		21145587	69209166	35	5280											
SPAG5	10615	broad.mit.edu	37	chr17	26911445	26911445	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atgggtatgctgactctgtaGctcttttagctggctgtcca	11	9	2	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr17:26911445G>C	uc002hbq.2	-	12	2307	c.2215C>G	c.(2215-2217)CTA>GTA	p.L739V	SGK494_uc010waq.1_Intron	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	739	Gln-rich.				cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					TGACTCTGTAGCTCTTTTAGC	0.512													C	26911445	C	C	26911445	3	2	78	1	0	0	0	0	1	0	0	0	14981	962	34	5	1418	5	SPAG5	17	26911445	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08		26911445	54283765	36	5281											
HNF1B	6928	broad.mit.edu	37	chr17	36065013	36065013	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggagaggctgtggatattcGtcaaggtgctgactgggggc	19	6	1	2			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr17:36065013G>A	uc002hok.3	-	6	1471	c.1250C>T	c.(1249-1251)ACG>ATG	p.T417M	HNF1B_uc010wdi.1_Missense_Mutation_p.T391M	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	417					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GTGGATATTCGTCAAGGTGCT	0.478									Hereditary_Prostate_Cancer				A	36065013	A	A	36065013	3	1	78	1	0	0	0	0	1	0	0	0	7252	1145	40	1	439	1	HNF1B	17	36065013	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	9153568	36065013	45130197	37	5282											
FBXL20	84961	broad.mit.edu	37	chr17	37431297	37431297	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gagcagccagaggcacaaagGgattgtaacttatggcaccc	12	10	0	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr17:37431297G>T	uc010wed.1	-	10	974	c.753C>A	c.(751-753)TCC>TCA	p.S251S	FBXL20_uc002hrt.2_Silent_p.S251S|FBXL20_uc010cvu.2_Silent_p.S219S	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	251	LRR 7.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			AGGCACAAAGGGATTGTAACT	0.403													T	37431297	T	T	37431297	2	4	78	1	0	0	0	0	0	0	0	1	5717	1219	43	5		5	FBXL20	17	37431297	Silent	SNP	G	TCGA-06-2561-01A-02D-1494-08	1366284	37431297	43763913	38	5283											
POTEC	388468	broad.mit.edu	37	chr18	14542851	14542851	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagtgacagcaccacttgcCcatcttgctcctgagcgtct	9	15	2	2			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr18:14542851C>T	uc010dln.2	-	1	749	c.295G>A	c.(295-297)GGC>AGC	p.G99S	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	99										skin(3)	3						CACCACTTGCCCATCTTGCTC	0.622													T	14542851	T	T	14542851	3	4	78	1	0	0	0	0	1	0	0	0	12262	623	22	3	1377	3	POTEC	18	14542851	Missense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08		14542851	63534397	39	5284											
KCNG2	26251	broad.mit.edu	37	chr18	77659449	77659449	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggtgcacctggccgagcGcgagctgggcgcgcgccgcg	18	15	0	0			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr18:77659449G>A	uc010xfl.1	+	2	1034	c.1034G>A	c.(1033-1035)CGC>CAC	p.R345H		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	345					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CTGGCCGAGCGCGAGCTGGGC	0.716													A	77659449	A	A	77659449	3	1	78	1	0	0	0	0	1	0	0	0	8028	1087	38	1	1040	1	KCNG2	18	77659449	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	63116598	77659449	417799	40	5285											
ITGB1BP3	27231	broad.mit.edu	37	chr19	3942189	3942189	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcagccccctccccggctcGcccagccaggacacagggac	10	20	1	0			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr19:3942189G>A	uc002lyz.3	+	8	901	c.611G>A	c.(610-612)CGC>CAC	p.R204H	ITGB1BP3_uc010xia.1_Missense_Mutation_p.R209H	NM_170678	NP_733778	Q9NPI5	NRK2_HUMAN	integrin beta 1 binding protein 3	204					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|protein binding|ribosylnicotinamide kinase activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00463)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCCGGCTCGCCCAGCCAGG	0.647													A	3942189	A	A	3942189	3	1	78	1	0	0	0	0	1	0	0	0	7893	1087	38	1	637	1	ITGB1BP3	19	3942189	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08		3942189	55186794	41	5286											
CCDC105	126402	broad.mit.edu	37	chr19	15132177	15132177	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttgcagcgtgcgccttggCgctaaacgaagccaagcggt	13	11	0	0			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr19:15132177C>T	uc002nae.2	+	4	986	c.887C>T	c.(886-888)GCG>GTG	p.A296V		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	296					microtubule cytoskeleton organization	microtubule				ovary(1)	1						TGCGCCTTGGCGCTAAACGAA	0.597													T	15132177	T	T	15132177	3	4	78	1	0	0	0	0	1	0	0	0	2740	768	27	1	901	1	CCDC105	19	15132177	Missense_Mutation	SNP	C	TCGA-06-2561-01A-02D-1494-08	11189988	15132177	43996806	42	5287											
ZNF208	7757	broad.mit.edu	37	chr19	22155492	22155492	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcggttaaaagctttgccacAttcttcacatttgtagggtt	8	8	2	0			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr19:22155492A>C	uc002nqp.2	-	5	2193	c.2044T>G	c.(2044-2046)TGT>GGT	p.C682G	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GCTTTGCCACATTCTTCACAT	0.358													C	22155492	C	C	22155492	3	2	78	1	0	0	0	0	1	0	0	0	17763	217	8	5	1502	5	ZNF208	19	22155492	Missense_Mutation	SNP	A	TCGA-06-2561-01A-02D-1494-08	7023315	22155492	36973491	43	5288											
LIPI	149998	broad.mit.edu	37	chr21	15561699	15561699	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taaatctctgaaggaatcctTtacacttagctgagagaatt	7	7	1	3			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chr21:15561699T>C	uc002yjm.2	-	2	161	c.151A>G	c.(151-153)AAG>GAG	p.K51E	LIPI_uc010gkw.1_5'UTR	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	30					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		AAGGAATCCTTTACACTTAGC	0.358													C	15561699	C	C	15561699	3	2	78	1	0	0	0	0	1	0	0	0	8825	1850	64	4	1330	4	LIPI	21	15561699	Missense_Mutation	SNP	T	TCGA-06-2561-01A-02D-1494-08		15561699	32568196	44	5289											
NUDT11	55190	broad.mit.edu	37	chrX	51239120	51239120	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctctcggaccgccgcaccGcccggctcctcctcgggctc	10	22	1	0			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chrX:51239120G>A	uc010njt.2	-	1	340	c.177C>T	c.(175-177)GGC>GGT	p.G59G		NM_018159	NP_060629	Q96G61	NUD11_HUMAN	nudix-type motif 11	59	Nudix box.|Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					CCGCCGCACCGCCCGGCTCCT	0.662										HNSCC(48;0.14)			A	51239120	A	A	51239120	2	1	78	1	0	0	0	0	0	0	0	1	10727	1074	38	1		1	NUDT11	23	51239120	Silent	SNP	G	TCGA-06-2561-01A-02D-1494-08		51239120	104031440	45	5290											
STAG2	10735	broad.mit.edu	37	chrX	123197901	123197901	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cttgaagattttctgcaagaGgtatatattataactattac	6	5	1	3			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chrX:123197901G>C	uc004etz.3	+	19	2364	c.2025G>C	c.(2023-2025)GAG>GAC	p.E675D	STAG2_uc004eua.2_Missense_Mutation_p.E675D|STAG2_uc004eub.2_Missense_Mutation_p.E675D|STAG2_uc004euc.2_Missense_Mutation_p.E675D|STAG2_uc004eud.2_Missense_Mutation_p.E675D|STAG2_uc004eue.2_Missense_Mutation_p.E675D	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	675					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TTCTGCAAGAGGTATATATTA	0.358													C	123197901	C	C	123197901	3	2	78	1	0	0	0	0	1	0	0	0	15242	1014	35	5	2095	5	STAG2	23	123197901	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	71958781	123197901	32072659	46	5291											
DDX26B	203522	broad.mit.edu	37	chrX	134679466	134679466	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgatttgttaaatctcaataGattaatatctggaatagaca	6	4	2	3			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chrX:134679466G>A	uc004eyw.3	+	3	671	c.308G>A	c.(307-309)AGA>AAA	p.R103K		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	103	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)					AATCTCAATAGATTAATATCT	0.353													A	134679466	A	A	134679466	3	1	78	1	0	0	0	0	1	0	0	0	4353	942	33	3	318	3	DDX26B	23	134679466	Missense_Mutation	SNP	G	TCGA-06-2561-01A-02D-1494-08	11481565	134679466	20591094	47	5292											
SAGE1	55511	broad.mit.edu	37	chrX	134993470	134993470	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgtcaggagctggtatttcaTgcagaagtaccagggatctg	13	7	3	1			TCGA-06-2561-01A-02D-1494-08	TCGA-06-2561-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f9898ad3-f9b6-4061-90ef-30e0eab0a706	3ba723ff-f198-433e-90f9-7bc0f3a0aa7a	g.chrX:134993470T>A	uc004ezh.2	+	17	2292	c.2125T>A	c.(2125-2127)TGC>AGC	p.C709S	SAGE1_uc010nry.1_Missense_Mutation_p.C678S|SAGE1_uc011mvv.1_Missense_Mutation_p.C333S	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	709										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TGGTATTTCATGCAGAAGTAC	0.453													A	134993470	A	A	134993470	3	1	78	1	0	0	0	0	1	0	0	0	13809	1464	51	5	2187	5	SAGE1	23	134993470	Missense_Mutation	SNP	T	TCGA-06-2561-01A-02D-1494-08	314004	134993470	20277090	48	5293											
FBLIM1	54751	broad.mit.edu	37	chr1	16093947	16093947	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctcccaccccctccaccGccccctccagtgcttctgcc	4	26	1	0	rs138682032		TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:16093947G>A	uc001axd.1	+	5	770	c.327G>A	c.(325-327)CCG>CCA	p.P109P	FBLIM1_uc001axe.1_Silent_p.P109P|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Silent_p.P109P|FBLIM1_uc001axh.1_Intron|FBLIM1_uc001axi.1_Intron	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	109	Pro-rich.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		CCCCTCCACCGCCCCCTCCAG	0.657													A	16093947	A	A	16093947	2	1	79	1	0	0	0	0	0	0	0	1	5697	1074	38	1		1	FBLIM1	1	16093947	Silent	SNP	G	TCGA-06-2562-01A-01D-1494-08		16093947	233156674	1	5294											
AKR7A3	22977	broad.mit.edu	37	chr1	19615062	19615062	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggactggccctcgctgtacaCgaaggccgtgtctatctcgg	13	13	2	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:19615062C>G	uc001bbv.1	-	1	219	c.142G>C	c.(142-144)GTG>CTG	p.V48L		NM_012067	NP_036199	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3	48					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TCGCTGTACACGAAGGCCGTG	0.711													G	19615062	G	G	19615062	3	3	79	1	0	0	0	0	1	0	0	0	476	536	19	5	881	5	AKR7A3	1	19615062	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	3521115	19615062	229635559	2	5295											
C1orf103	55791	broad.mit.edu	37	chr1	111494470	111494470	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aataggcatatttttggatcGcgtcccactaggatcgatgg	11	8	0	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:111494470G>A	uc001eaa.2	-	2	1292	c.1036C>T	c.(1036-1038)CGA>TGA	p.R346*	C1orf103_uc001dzz.2_Intron|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		TTTTTGGATCGCGTCCCACTA	0.353													A	111494470	A	A	111494470	4	1	79	1	0	0	0	0	0	1	0	0	1977	1095	38	1	1285	1	C1orf103	1	111494470	Nonsense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	91879408	111494470	137756151	3	5296											
HIPK1	204851	broad.mit.edu	37	chr1	114508833	114508833	+	Missense_Mutation	SNP	G	T	T													gggtagctctacacaactctGtccagcccacagcaatgatt							TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:114508833G>T	uc001eem.2	+	11	2481	c.2320G>T	c.(2320-2322)GTC>TTC	p.V774F	HIPK1_uc001eel.2_Missense_Mutation_p.V774F|HIPK1_uc001een.2_Missense_Mutation_p.V774F|HIPK1_uc001eeo.2_Missense_Mutation_p.V400F|HIPK1_uc001eep.2_Missense_Mutation_p.V380F|HIPK1_uc001eeq.2_Missense_Mutation_p.V66F	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	774					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACACAACTCTGTCCAGCCCAC	0.542													T	114508833	T	T	114508833	3	4	79	1	0	0	0	0	1	0	0	0	7116	1377	48	5	2376	5	HIPK1	1	114508833	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	3014363	114508833	134741788	4	5297	8	2									
HIPK1	204851	broad.mit.edu	37	chr1	114508840	114508840	+	Missense_Mutation	SNP	C	A	A													tctacacaactctgtccagcCcacagcaatgattccagagg							TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:114508840C>A	uc001eem.2	+	11	2488	c.2327C>A	c.(2326-2328)CCC>CAC	p.P776H	HIPK1_uc001eel.2_Missense_Mutation_p.P776H|HIPK1_uc001een.2_Missense_Mutation_p.P776H|HIPK1_uc001eeo.2_Missense_Mutation_p.P402H|HIPK1_uc001eep.2_Missense_Mutation_p.P382H|HIPK1_uc001eeq.2_Missense_Mutation_p.P68H	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	776					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTGTCCAGCCCACAGCAATG	0.552													A	114508840	A	A	114508840	3	1	79	1	0	0	0	0	1	0	0	0	7116	623	22	5	2383	5	HIPK1	1	114508840	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	7	114508840	134741781	5	5298	8	2									
SMG5	23381	broad.mit.edu	37	chr1	156235769	156235769	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cactggggcccagtgggccaTtgagggaatcgggagcctct	16	11	1	1	rs151295845	byFrequency	TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:156235769T>C	uc001foc.3	-	12	1807	c.1658A>G	c.(1657-1659)AAT>AGT	p.N553S	SMG5_uc009wrv.2_Missense_Mutation_p.N38S	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	553					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					CAGTGGGCCATTGAGGGAATC	0.607													C	156235769	C	C	156235769	3	2	79	1	0	0	0	0	1	0	0	0	14796	1493	52	4	1436	4	SMG5	1	156235769	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	41726929	156235769	93014852	6	5299											
CADM3	57863	broad.mit.edu	37	chr1	159162382	159162382	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccccagcccttcgagataatCgaattcagctggttacctct	7	14	2	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:159162382C>T	uc001ftl.2	+	3	386	c.244C>T	c.(244-246)CGA>TGA	p.R82*	CADM3_uc009wsx.1_Nonsense_Mutation_p.R116*|CADM3_uc009wsy.1_Nonsense_Mutation_p.R82*|CADM3_uc001ftk.2_Nonsense_Mutation_p.R116*	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	82	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					TCGAGATAATCGAATTCAGCT	0.512													T	159162382	T	T	159162382	4	4	79	1	0	0	0	0	0	1	0	0	2568	876	31	2	360	2	CADM3	1	159162382	Nonsense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	2926613	159162382	90088239	7	5300											
PVRL4	81607	broad.mit.edu	37	chr1	161049728	161049728	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaggtctccagctcacccgCggggcaccggcctgcagggg	16	15	2	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:161049728C>T	uc001fxo.2	-	2	390	c.91G>A	c.(91-93)GCG>ACG	p.A31T		NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	31					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			AGCTCACCCGCGGGGCACCGG	0.627													T	161049728	T	T	161049728	3	4	79	1	0	0	0	0	1	0	0	0	12842	768	27	1	1473	1	PVRL4	1	161049728	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	1887346	161049728	88200893	8	5301											
XCL1	6375	broad.mit.edu	37	chr1	168550427	168550427	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gccaacaggaacccagcaatCgaccaatacagctgtgactc	8	14	0	1	rs141027416		TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:168550427C>T	uc001gfo.1	+	3	334	c.314C>T	c.(313-315)TCG>TTG	p.S105L		NM_002995	NP_002986	P47992	XCL1_HUMAN	chemokine (C motif) ligand 1	105					CD4-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell proliferation|cell-cell signaling|cellular response to interleukin-4|cellular response to transforming growth factor beta stimulus|immunoglobulin production in mucosal tissue|lymphocyte chemotaxis|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell cytokine production|negative regulation of T-helper 1 cell activation|negative regulation of transcription, DNA-dependent|neutrophil chemotaxis|positive regulation of activated T cell proliferation|positive regulation of B cell chemotaxis|positive regulation of granzyme A production|positive regulation of granzyme B production|positive regulation of interleukin-10 production|positive regulation of natural killer cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell chemotaxis|positive regulation of T cell cytokine production|positive regulation of T cell mediated cytotoxicity|positive regulation of thymocyte migration|positive regulation of transforming growth factor-beta production|regulation of inflammatory response|release of sequestered calcium ion into cytosol|response to virus|T-helper 1 cell cytokine production|T-helper 2 cell cytokine production	extracellular space	chemokine activity|protein homodimerization activity				0	all_hematologic(923;0.208)					ACCCAGCAATCGACCAATACA	0.522													T	168550427	T	T	168550427	3	4	79	1	0	0	0	0	1	0	0	0	17420	893	31	2	324	2	XCL1	1	168550427	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	7500699	168550427	80700194	9	5302											
SELE	6401	broad.mit.edu	37	chr1	169697312	169697312	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcacagctggacccataaCggaaactgccagaagcacta	8	13	1	1	rs139137736		TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:169697312C>T	uc001ggm.3	-	8	1323	c.1166G>A	c.(1165-1167)CGT>CAT	p.R389H	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	389	Sushi 4.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GGACCCATAACGGAAACTGCC	0.522													T	169697312	T	T	169697312	3	4	79	1	0	0	0	0	1	0	0	0	14013	536	19	1	690	1	SELE	1	169697312	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	1146885	169697312	79553309	10	5303											
OR2M3	127062	broad.mit.edu	37	chr1	248367150	248367150	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctttgttcatgtacataCggcccacatctgatcgctcc	7	14	2	1	rs147728074	byFrequency	TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr1:248367150C>T	uc010pzg.1	+	1	781	c.781C>T	c.(781-783)CGG>TGG	p.R261W		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CATGTACATACGGCCCACATC	0.502													T	248367150	T	T	248367150	3	4	79	1	0	0	0	0	1	0	0	0	11011	527	19	1	783	1	OR2M3	1	248367150	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	78669838	248367150	883471	11	5304											
ADD2	119	broad.mit.edu	37	chr2	70901894	70901894	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggctgaaggggttgggcaCcgtctcctctgaatcgtctt	13	10	3	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr2:70901894C>T	uc002sgz.2	-	14	2122	c.1657G>A	c.(1657-1659)GTG>ATG	p.V553M	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_Missense_Mutation_p.V553M|ADD2_uc002sha.2_Missense_Mutation_p.V247M|ADD2_uc002sgx.2_Missense_Mutation_p.V553M|ADD2_uc010fdt.1_Missense_Mutation_p.V553M	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	553					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						GGGTTGGGCACCGTCTCCTCT	0.507													T	70901894	T	T	70901894	3	4	79	1	0	0	0	0	1	0	0	0	305	507	18	3	625	3	ADD2	2	70901894	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08		70901894	172297479	12	5305											
TTN	7273	broad.mit.edu	37	chr2	179446906	179446906	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atctttggttatgttgctaaTaacaggaggatcacagcgtc	10	7	2	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr2:179446906T>C	uc010zfg.1	-	264	58710	c.58486A>G	c.(58486-58488)ATT>GTT	p.I19496V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I13191V|TTN_uc010zfi.1_Missense_Mutation_p.I13124V|TTN_uc010zfj.1_Missense_Mutation_p.I12999V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20423							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTTGCTAATAACAGGAGGA	0.418													C	179446906	C	C	179446906	3	2	79	1	0	0	0	0	1	0	0	0	16732	1406	49	4	41981	4	TTN	2	179446906	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	108545012	179446906	63752467	13	5306											
OR5H2	79310	broad.mit.edu	37	chr3	98002586	98002586	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gactctgtcttttatacaatCataattcctttgctaaatcc	3	10	3	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr3:98002586C>T	uc003dsj.1	+	1	855	c.855C>T	c.(853-855)ATC>ATT	p.I285I		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						TTTATACAATCATAATTCCTT	0.328													T	98002586	T	T	98002586	2	4	79	1	0	0	0	0	0	0	0	1	11162	816	29	3		3	OR5H2	3	98002586	Silent	SNP	C	TCGA-06-2562-01A-01D-1494-08		98002586	100019844	14	5307											
HCLS1	3059	broad.mit.edu	37	chr3	121350755	121350755	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggccatggcaacgtccccGccaccagccctcgtccacca	9	20	0	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr3:121350755G>A	uc003eeh.3	-	14	1524	c.1399C>T	c.(1399-1401)CGG>TGG	p.R467W	HCLS1_uc011bjj.1_Missense_Mutation_p.R430W	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	467	SH3.				erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		CAACGTCCCCGCCACCAGCCC	0.507													A	121350755	A	A	121350755	3	1	79	1	0	0	0	0	1	0	0	0	6995	1086	38	1	65	1	HCLS1	3	121350755	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	23348169	121350755	76671675	15	5308											
ABTB1	80325	broad.mit.edu	37	chr3	127396603	127396603	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggagccagcgacctcagggGgccccccagccgtcaccctg	13	18	2	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr3:127396603G>T	uc003ejt.2	+	10	1034	c.946G>T	c.(946-948)GGC>TGC	p.G316C	ABTB1_uc003ejr.2_Missense_Mutation_p.G174C|ABTB1_uc003ejs.2_Missense_Mutation_p.G291C|ABTB1_uc003eju.2_Missense_Mutation_p.G174C|ABTB1_uc010hsm.2_Missense_Mutation_p.G43C	NM_172027	NP_742024	Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	316	BTB 2.					cytoplasm|nucleolus|plasma membrane	translation elongation factor activity				0						GACCTCAGGGGGCCCCCCAGC	0.642													T	127396603	T	T	127396603	3	4	79	1	0	0	0	0	1	0	0	0	102	1232	43	5	984	5	ABTB1	3	127396603	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	6045848	127396603	70625827	16	5309											
EPHB1	2047	broad.mit.edu	37	chr3	134967277	134967277	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacagccggccccggtttgcGgagattgtcaacaccctaga	11	13	1	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr3:134967277G>A	uc003eqt.2	+	14	2836	c.2616G>A	c.(2614-2616)GCG>GCA	p.A872A	EPHB1_uc003equ.2_Silent_p.A433A	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	872	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CCCGGTTTGCGGAGATTGTCA	0.582													A	134967277	A	A	134967277	2	1	79	1	0	0	0	0	0	0	0	1	5174	1103	39	2		2	EPHB1	3	134967277	Silent	SNP	G	TCGA-06-2562-01A-01D-1494-08	7570674	134967277	63055153	17	5310											
ZIC4	84107	broad.mit.edu	37	chr3	147108751	147108751	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggcggtacgcgccgccaccGccgccgaggaggccacctgg	16	18	0	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr3:147108751G>A	uc003ewd.1	-	4	1244	c.971C>T	c.(970-972)GCG>GTG	p.A324V	ZIC4_uc003ewc.1_Missense_Mutation_p.A254V|ZIC4_uc011bno.1_Missense_Mutation_p.A374V	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	324						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						CGCCGCCACCGCCGCCGAGGA	0.706													A	147108751	A	A	147108751	3	1	79	1	0	0	0	0	1	0	0	0	17678	1087	38	1	41	1	ZIC4	3	147108751	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	12141474	147108751	50913679	18	5311											
GAK	2580	broad.mit.edu	37	chr4	864620	864620	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcggcctgtccctgggctcCacctccacttccaggttcac	8	19	1	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr4:864620C>T	uc003gbm.3	-	19	2326	c.2127G>A	c.(2125-2127)GTG>GTA	p.V709V	GAK_uc003gbn.3_Silent_p.V630V|GAK_uc010ibk.1_Silent_p.V603V|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Silent_p.V573V	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	709	C2 tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		CCCTGGGCTCCACCTCCACTT	0.557													T	864620	T	T	864620	2	4	79	1	0	0	0	0	0	0	0	1	6195	581	21	3		3	GAK	4	864620	Silent	SNP	C	TCGA-06-2562-01A-01D-1494-08		864620	190289656	19	5312											
ATP8A1	10396	broad.mit.edu	37	chr4	42505527	42505527	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttcttcaacagtttgcaggaGtgtcctgtatccaaacacag	8	10	2	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr4:42505527G>C	uc003gwr.2	-	24	2323	c.2091C>G	c.(2089-2091)CAC>CAG	p.H697Q	ATP8A1_uc003gwq.2_5'UTR|ATP8A1_uc003gws.2_Missense_Mutation_p.H682Q	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	697	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	GTTTGCAGGAGTGTCCTGTAT	0.274													C	42505527	C	C	42505527	3	2	79	1	0	0	0	0	1	0	0	0	1192	1020	36	5	1459	5	ATP8A1	4	42505527	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	41640907	42505527	148648749	20	5313											
SLC4A4	8671	broad.mit.edu	37	chr4	72316924	72316924	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaagaatatgtactcaggtGgagagaatgttcagatgaat	12	3	2	4			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr4:72316924G>A	uc003hfy.2	+	11	1345	c.1228G>A	c.(1228-1230)GGA>AGA	p.G410R	SLC4A4_uc010iic.2_Missense_Mutation_p.G410R|SLC4A4_uc010iib.2_Missense_Mutation_p.G410R|SLC4A4_uc003hfz.2_Missense_Mutation_p.G410R|SLC4A4_uc003hgc.3_Missense_Mutation_p.G366R|SLC4A4_uc010iid.2_5'UTR|SLC4A4_uc003hga.2_Missense_Mutation_p.G288R|SLC4A4_uc003hgb.3_Missense_Mutation_p.G366R	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	410	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GTACTCAGGTGGAGAGAATGT	0.443													A	72316924	A	A	72316924	3	1	79	1	0	0	0	0	1	0	0	0	14656	1349	47	3	1387	3	SLC4A4	4	72316924	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	29811397	72316924	118837352	21	5314											
PPEF2	5470	broad.mit.edu	37	chr4	76797562	76797562	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctgcttgctgccggcaccGctctagctccagttccacgg	11	17	1	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr4:76797562G>A	uc003hix.2	-	11	1555	c.1198C>T	c.(1198-1200)CGG>TGG	p.R400W	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.R400W	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	400	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGCCGGCACCGCTCTAGCTCC	0.667													A	76797562	A	A	76797562	3	1	79	1	0	0	0	0	1	0	0	0	12308	1086	38	1	1091	1	PPEF2	4	76797562	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	4480638	76797562	114356714	22	5315											
SHROOM3	57619	broad.mit.edu	37	chr4	77661370	77661370	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcagcctggagctaggcCggggaacccaggagggttac	16	11	0	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr4:77661370C>T	uc011cbx.1	+	5	2997	c.2044C>T	c.(2044-2046)CGG>TGG	p.R682W	SHROOM3_uc011cbz.1_Missense_Mutation_p.R506W|SHROOM3_uc003hkf.1_Missense_Mutation_p.R557W|SHROOM3_uc003hkg.2_Missense_Mutation_p.R460W	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	682					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GGAGCTAGGCCGGGGAACCCA	0.607													T	77661370	T	T	77661370	3	4	79	1	0	0	0	0	1	0	0	0	14295	643	23	2	2062	2	SHROOM3	4	77661370	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	863808	77661370	113492906	23	5316											
FAM190A	401145	broad.mit.edu	37	chr4	91321221	91321221	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttgggatcttgtgaactggAtgaagatgatctaatgcttg	12	4	2	4			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr4:91321221A>G	uc003hsv.3	+	4	1884	c.1544A>G	c.(1543-1545)GAT>GGT	p.D515G	FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.D515G	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	515										large_intestine(1)|ovary(1)	2						TGTGAACTGGATGAAGATGAT	0.333													G	91321221	G	G	91321221	3	3	79	1	0	0	0	0	1	0	0	0	5521	333	12	4	1554	4	FAM190A	4	91321221	Missense_Mutation	SNP	A	TCGA-06-2562-01A-01D-1494-08	13659851	91321221	99833055	24	5317											
CTNND2	1501	broad.mit.edu	37	chr5	11565132	11565132	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctacgatctgccgttcagCctccagctctcgggtcagcc	11	16	4	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr5:11565132C>T	uc003jfa.1	-	3	356	c.211G>A	c.(211-213)GCT>ACT	p.A71T	CTNND2_uc010itt.2_5'UTR|CTNND2_uc011cmy.1_5'UTR|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	71	Potential.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGCCGTTCAGCCTCCAGCTCT	0.502													T	11565132	T	T	11565132	3	4	79	1	0	0	0	0	1	0	0	0	4020	739	26	3	3546	3	CTNND2	5	11565132	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08		11565132	169350128	25	5318											
PIK3R1	5295	broad.mit.edu	37	chr5	67591125	67591125	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taaaccagaccttatccagcTgagaaagacgagagaccaat	8	10	0	4			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr5:67591125T>C	uc003jva.2	+	13	2278	c.1718T>C	c.(1717-1719)CTG>CCG	p.L573P	PIK3R1_uc003jvb.2_Missense_Mutation_p.L573P|PIK3R1_uc003jvc.2_Missense_Mutation_p.L273P|PIK3R1_uc003jvd.2_Missense_Mutation_p.L303P|PIK3R1_uc003jve.2_Missense_Mutation_p.L252P|PIK3R1_uc011crb.1_Missense_Mutation_p.L243P	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	573					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.L570_D578del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CTTATCCAGCTGAGAAAGACG	0.383			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			C	67591125	C	C	67591125	3	2	79	1	0	0	0	0	1	0	0	0	11918	1580	55	4	1894	4	PIK3R1	5	67591125	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	56025993	67591125	113324135	26	5319											
PRR16	51334	broad.mit.edu	37	chr5	120021968	120021968	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctacgaaatggaggcttacCaggtggacctaacaaaattc	9	9	1	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr5:120021968C>A	uc003ksq.2	+	2	642	c.479C>A	c.(478-480)CCA>CAA	p.P160Q	PRR16_uc003ksp.2_Missense_Mutation_p.P137Q|PRR16_uc003ksr.2_Missense_Mutation_p.P90Q	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	160	Pro-rich.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		GGAGGCTTACCAGGTGGACCT	0.468													A	120021968	A	A	120021968	3	1	79	1	0	0	0	0	1	0	0	0	12589	594	21	5	416	5	PRR16	5	120021968	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	52430843	120021968	60893292	27	5320											
SGCD	6444	broad.mit.edu	37	chr5	156186311	156186311	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggaacgaggcagaaggtcttCgagatctgcgtctgcgccaa	14	10	3	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr5:156186311C>T	uc003lwd.3	+	8	1256	c.780C>T	c.(778-780)TTC>TTT	p.F260F	SGCD_uc003lwc.3_Silent_p.F261F	NM_001128209	NP_001121681	Q92629	SGCD_HUMAN	delta-sarcoglycan isoform 3	260	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAAGGTCTTCGAGATCTGCG	0.488													T	156186311	T	T	156186311	2	4	79	1	0	0	0	0	0	0	0	1	14201	883	31	2		2	SGCD	5	156186311	Silent	SNP	C	TCGA-06-2562-01A-01D-1494-08	36164343	156186311	24728949	28	5321											
ADAMTS2	9509	broad.mit.edu	37	chr5	178552111	178552111	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtagcggctgaatgcagcGcacggagcgcacctgcatgc	15	12	0	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr5:178552111G>A	uc003mjw.2	-	19	2821	c.2821C>T	c.(2821-2823)CGC>TGC	p.R941C		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	941	TSP type-1 3.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TGAATGCAGCGCACGGAGCGC	0.692													A	178552111	A	A	178552111	3	1	79	1	0	0	0	0	1	0	0	0	265	1087	38	1	830	1	ADAMTS2	5	178552111	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	22365800	178552111	2363149	29	5322											
GMDS	2762	broad.mit.edu	37	chr6	1930436	1930436	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaatcttagctactgaccgGctaatttttcgagtaacgaa	7	8	1	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr6:1930436G>A	uc003mtq.2	-	7	862	c.672C>T	c.(670-672)AGC>AGT	p.S224S		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	224					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		CTACTGACCGGCTAATTTTTC	0.428													A	1930436	A	A	1930436	2	1	79	1	0	0	0	0	0	0	0	1	6486	1194	42	3		3	GMDS	6	1930436	Silent	SNP	G	TCGA-06-2562-01A-01D-1494-08		1930436	169184631	30	5323											
ZSCAN23	222696	broad.mit.edu	37	chr6	28402496	28402496	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttgccacaaacactgcactGgtagcgcttctccccagtgt	8	14	1	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr6:28402496G>C	uc003nli.3	-	4	1097	c.916C>G	c.(916-918)CAG>GAG	p.Q306E	ZSCAN23_uc003nlh.2_RNA|ZSCAN23_uc010jrf.1_RNA|ZSCAN23_uc011dli.1_3'UTR	NM_001012455	NP_001012458	Q3MJ62	ZSC23_HUMAN	zinc finger protein 390	306	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACACTGCACTGGTAGCGCTTC	0.542													C	28402496	C	C	28402496	3	2	79	1	0	0	0	0	1	0	0	0	18232	1357	47	5	257	5	ZSCAN23	6	28402496	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	26472060	28402496	142712571	31	5324											
PPP1R10	5514	broad.mit.edu	37	chr6	30570090	30570090	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcatgggggcgatgcccaCttcccatgccaccgccaggg	12	16	1	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr6:30570090C>T	uc003nqn.1	-	19	2888	c.2336G>A	c.(2335-2337)AGT>AAT	p.S779N	PPP1R10_uc010jsc.1_Missense_Mutation_p.S433N	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	779	Gly-rich.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						GCGATGCCCACTTCCCATGCC	0.672													T	30570090	T	T	30570090	3	4	79	1	0	0	0	0	1	0	0	0	12352	565	20	3	494	3	PPP1R10	6	30570090	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	2167594	30570090	140544977	32	5325											
SFRS18	25957	broad.mit.edu	37	chr6	99856145	99856145	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagagtcctgcgttttactgCgtctgtttcacgtgggaaaa	11	8	2	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr6:99856145C>T	uc003ppo.3	-	7	904	c.676G>A	c.(676-678)GCA>ACA	p.A226T	SFRS18_uc003ppp.3_Missense_Mutation_p.A226T|SFRS18_uc011eag.1_Missense_Mutation_p.A226T|SFRS18_uc003ppr.2_Missense_Mutation_p.A226T	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	226						nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)		CGTTTTACTGCGTCTGTTTCA	0.358													T	99856145	T	T	99856145	3	4	79	1	0	0	0	0	1	0	0	0	14174	768	27	1	1765	1	SFRS18	6	99856145	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	69286055	99856145	71258922	33	5326											
ATG5	9474	broad.mit.edu	37	chr6	106764059	106764059	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcgtccaaaccacacatctcGaagcacatctttgtcatctg	5	14	4	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr6:106764059G>A	uc003prf.2	-	2	378	c.25C>T	c.(25-27)CGA>TGA	p.R9*	ATG5_uc010kdb.2_Nonsense_Mutation_p.R9*|ATG5_uc003prg.2_5'UTR|ATG5_uc010kdc.2_Nonsense_Mutation_p.R9*	NM_004849	NP_004840	Q9H1Y0	ATG5_HUMAN	APG5 autophagy 5-like	9					apoptosis|autophagic vacuole assembly|negative regulation of type I interferon production|post-translational protein modification	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			large_intestine(1)	1	Breast(9;0.0296)	all_cancers(87;0.000301)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0612)|Lung NSC(302;0.216)	BRCA - Breast invasive adenocarcinoma(8;0.00802)	OV - Ovarian serous cystadenocarcinoma(136;0.128)|Epithelial(106;0.159)|all cancers(137;0.18)		CACACATCTCGAAGCACATCT	0.368													A	106764059	A	A	106764059	4	1	79	1	0	0	0	0	0	1	0	0	1100	1066	37	2	830	2	ATG5	6	106764059	Nonsense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	6907914	106764059	64351008	34	5327											
TXLNB	167838	broad.mit.edu	37	chr6	139564240	139564240	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cggcggtttggacactattaAcctcctctgcgtcaatctct	8	13	3	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr6:139564240A>T	uc011eds.1	-	10	1643	c.1478T>A	c.(1477-1479)GTT>GAT	p.V493D		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	493						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		GACACTATTAACCTCCTCTGC	0.478													T	139564240	T	T	139564240	3	4	79	1	0	0	0	0	1	0	0	0	16785	43	2	5	580	5	TXLNB	6	139564240	Missense_Mutation	SNP	A	TCGA-06-2562-01A-01D-1494-08	32800181	139564240	31550827	35	5328											
PRPS1L1	221823	broad.mit.edu	37	chr7	18066565	18066565	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tattttggagcaatgcttcaTcttctcatcttgaggtatgg	9	7	4	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr7:18066565T>C	uc003stz.2	-	1	922	c.841A>G	c.(841-843)ATG>GTG	p.M281V		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	281					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					CAATGCTTCATCTTCTCATCT	0.438													C	18066565	C	C	18066565	3	2	79	1	0	0	0	0	1	0	0	0	12579	1435	50	4	119	4	PRPS1L1	7	18066565	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08		18066565	141072098	36	5329											
PKD1L1	168507	broad.mit.edu	37	chr7	47867036	47867036	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tggtggatgcgcccagcgcaGgtggcgagcttgttgtcggg	19	9	0	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr7:47867036G>C	uc003tny.1	-	45	6766	c.6766C>G	c.(6766-6768)CTG>GTG	p.L2256V	C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_5'UTR	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2256	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GCCCAGCGCAGGTGGCGAGCT	0.667													C	47867036	C	C	47867036	3	2	79	1	0	0	0	0	1	0	0	0	11964	991	35	5	1835	5	PKD1L1	7	47867036	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	29800471	47867036	111271627	37	5330											
CALN1	83698	broad.mit.edu	37	chr7	71252855	71252855	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcatatgaggctcttccggaCgcaggtctgtctgttctgct	12	11	4	1	rs144352678	by1000genomes	TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr7:71252855C>T	uc003twa.3	-	6	1092	c.565G>A	c.(565-567)GTC>ATC	p.V189I	CALN1_uc003twb.3_Missense_Mutation_p.V231I|CALN1_uc003twc.3_Missense_Mutation_p.V189I	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	189	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CTCTTCCGGACGCAGGTCTGT	0.537													T	71252855	T	T	71252855	3	4	79	1	0	0	0	0	1	0	0	0	2591	536	19	1	98	1	CALN1	7	71252855	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	23385819	71252855	87885808	38	5331											
ZAN	7455	broad.mit.edu	37	chr7	100336230	100336230	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgatggcgacttctctagcCctggtagtgagtagcggcca	13	11	1	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr7:100336230C>T	uc003uwj.2	+	7	925	c.760C>T	c.(760-762)CCT>TCT	p.P254S	ZAN_uc003uwk.2_Missense_Mutation_p.P254S|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	254	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTTCTCTAGCCCTGGTAGTGA	0.577													T	100336230	T	T	100336230	3	4	79	1	0	0	0	0	1	0	0	0	17510	623	22	3	782	3	ZAN	7	100336230	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	29083375	100336230	58802433	39	5332											
OPN1SW	611	broad.mit.edu	37	chr7	128415497	128415497	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttttcccctgcagtacctgcTacagtgcccaggaagccctc	8	16	0	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr7:128415497T>A	uc003vnt.3	-	1	348	c.348A>T	c.(346-348)GTA>GTT	p.V116V		NM_001708	NP_001699	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	116	Helical; Name=3; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0						CAGTACCTGCTACAGTGCCCA	0.547													A	128415497	A	A	128415497	2	1	79	1	0	0	0	0	0	0	0	1	10880	1509	53	5		5	OPN1SW	7	128415497	Silent	SNP	T	TCGA-06-2562-01A-01D-1494-08	28079267	128415497	30723166	40	5333											
TTC26	79989	broad.mit.edu	37	chr7	138854079	138854079	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagttcttccagttggtgggAggatcagctagtgaatgtgg	15	6	2	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr7:138854079A>G	uc003vus.2	+	12	1164	c.1050A>G	c.(1048-1050)GGA>GGG	p.G350G	TTC26_uc011kqn.1_Silent_p.G350G|TTC26_uc011kqo.1_Silent_p.G319G|TTC26_uc011kqp.1_Silent_p.G245G|TTC26_uc003vut.2_Silent_p.G210G|TTC26_uc011kqq.1_Silent_p.G219G	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	350							binding			ovary(1)	1						AGTTGGTGGGAGGATCAGCTA	0.368													G	138854079	G	G	138854079	2	3	79	1	0	0	0	0	0	0	0	1	16691	291	11	4		4	TTC26	7	138854079	Silent	SNP	A	TCGA-06-2562-01A-01D-1494-08	10438582	138854079	20284584	41	5334											
GIMAP5	55340	broad.mit.edu	37	chr7	150439564	150439564	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctctgccccggggccccacGtcctgcttctggtgatccag	11	17	2	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr7:150439564G>A	uc003whr.1	+	3	689	c.337G>A	c.(337-339)GTC>ATC	p.V113I	GIMAP5_uc010lpu.2_5'UTR	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	113	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGGCCCCACGTCCTGCTTCT	0.587													A	150439564	A	A	150439564	3	1	79	1	0	0	0	0	1	0	0	0	6382	1145	40	1	343	1	GIMAP5	7	150439564	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	11585485	150439564	8699099	42	5335											
PIP5K1B	8395	broad.mit.edu	37	chr9	71606125	71606125	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacttgaccgctgagcccaaCactctggaagtgcaggatga	11	11	1	3			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr9:71606125C>T	uc004agu.2	+	15	1877	c.1572C>T	c.(1570-1572)AAC>AAT	p.N524N	PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	524						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		CTGAGCCCAACACTCTGGAAG	0.428													T	71606125	T	T	71606125	2	4	79	1	0	0	0	0	0	0	0	1	11940	477	17	3		3	PIP5K1B	9	71606125	Silent	SNP	C	TCGA-06-2562-01A-01D-1494-08		71606125	69607306	43	5336											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112694260	112694260	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgccaatcctctgttcaCgaacagcagaaccatcacct	5	16	3	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr9:112694260C>T	uc004bei.2	+	6	640	c.448C>T	c.(448-450)CGA>TGA	p.R150*	PALM2_uc004bef.2_Nonsense_Mutation_p.R152*|PALM2_uc004beg.2_Intron|PALM2_uc004beh.3_Nonsense_Mutation_p.R150*|PALM2-AKAP2_uc004bek.3_Nonsense_Mutation_p.R150*|PALM2-AKAP2_uc004bej.3_Nonsense_Mutation_p.R150*|PALM2-AKAP2_uc004bel.1_Intron	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:Variant_position_missing_in_Q9Y2D5_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CCTCTGTTCACGAACAGCAGA	0.542													T	112694260	T	T	112694260	4	4	79	1	0	0	0	0	0	1	0	0	11410	528	19	1	470	1	PALM2-AKAP2	9	112694260	Nonsense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	41088135	112694260	28519171	44	5337											
SLC46A2	57864	broad.mit.edu	37	chr9	115652657	115652657	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggagatctttcggtggtagCggtcgctgagccatcccagc	14	11	1	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr9:115652657C>T	uc004bgk.2	-	1	537	c.305G>A	c.(304-306)CGC>CAC	p.R102H		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	102	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						TCGGTGGTAGCGGTCGCTGAG	0.607													T	115652657	T	T	115652657	3	4	79	1	0	0	0	0	1	0	0	0	14645	768	27	1	1138	1	SLC46A2	9	115652657	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	2958397	115652657	25560774	45	5338											
SLIT1	6585	broad.mit.edu	37	chr10	98808848	98808848	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccacttgaggttacagtcGcaaatgaaagggttctgcgc	12	9	1	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr10:98808848G>A	uc001kmw.2	-	14	1581	c.1329C>T	c.(1327-1329)TGC>TGT	p.C443C	SLIT1_uc009xvh.1_Silent_p.C453C	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	443	LRRCT 2.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GGTTACAGTCGCAAATGAAAG	0.617													A	98808848	A	A	98808848	2	1	79	1	0	0	0	0	0	0	0	1	14739	1079	38	1		1	SLIT1	10	98808848	Silent	SNP	G	TCGA-06-2562-01A-01D-1494-08		98808848	36725899	46	5339											
RBMXL2	27288	broad.mit.edu	37	chr11	7111073	7111073	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccggagagtacacccaccGcgattacggccactccagtg	11	16	0	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr11:7111073G>A	uc001mfc.2	+	1	909	c.722G>A	c.(721-723)CGC>CAC	p.R241H		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	241	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TACACCCACCGCGATTACGGC	0.662													A	7111073	A	A	7111073	3	1	79	1	0	0	0	0	1	0	0	0	13154	1087	38	1	724	1	RBMXL2	11	7111073	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08		7111073	127895443	47	5340											
ABCC8	6833	broad.mit.edu	37	chr11	17419338	17419338	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagcaccacacatgcaccgaTgtactcctggggagggagag	14	11	0	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr11:17419338T>C	uc001mnc.2	-	31	3886	c.3760A>G	c.(3760-3762)ATC>GTC	p.I1254V		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1254	Helical; Name=16; (By similarity).|ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CATGCACCGATGTACTCCTGG	0.632													C	17419338	C	C	17419338	3	2	79	1	0	0	0	0	1	0	0	0	58	1464	51	4	1021	4	ABCC8	11	17419338	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	10308265	17419338	117587178	48	5341											
MS4A14	84689	broad.mit.edu	37	chr11	60183620	60183620	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcaagacacaccatcccaCgccatgccacctcaagacat	4	18	2	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr11:60183620C>T	uc001npj.2	+	5	1744	c.1179C>T	c.(1177-1179)CAC>CAT	p.H393H	MS4A14_uc001npi.2_Silent_p.H281H|MS4A14_uc001npn.2_Silent_p.H131H|MS4A14_uc001npk.2_Silent_p.H376H|MS4A14_uc001npl.2_Silent_p.H131H|MS4A14_uc001npm.2_Silent_p.H131H	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	393						integral to membrane	receptor activity			breast(1)	1						caccatcccacgccatgccac	0.075													T	60183620	T	T	60183620	2	4	79	1	0	0	0	0	0	0	0	1	9858	535	19	1		1	MS4A14	11	60183620	Silent	SNP	C	TCGA-06-2562-01A-01D-1494-08	42764282	60183620	74822896	49	5342											
LRP5	4041	broad.mit.edu	37	chr11	68177525	68177525	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accaacagaatcgaagtggcGcggctggacgggcagttccg	15	11	0	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr11:68177525G>A	uc001ont.2	+	10	2310	c.2235G>A	c.(2233-2235)GCG>GCA	p.A745A	LRP5_uc009ysg.2_Silent_p.A155A	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	745	LDL-receptor class B 12.|Beta-propeller 3.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						TCGAAGTGGCGCGGCTGGACG	0.617													A	68177525	A	A	68177525	2	1	79	1	0	0	0	0	0	0	0	1	8960	1074	38	1		1	LRP5	11	68177525	Silent	SNP	G	TCGA-06-2562-01A-01D-1494-08	7993905	68177525	66828991	50	5343											
CBL	867	broad.mit.edu	37	chr11	119148932	119148932	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttccaactatgtaaaatatgTgctgaaaatgataaggatgt	8	4	0	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr11:119148932T>G	uc001pwe.2	+	8	1290	c.1152T>G	c.(1150-1152)TGT>TGG	p.C384W		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	384	Asp/Glu-rich (acidic).|RING-type.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.E366_Q409del(13)|p.C384R(7)|p.C384Y(4)|p.E369_D390del(1)|p.E366_K477del(1)		haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		GTAAAATATGTGCTGAAAATG	0.353									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				G	119148932	G	G	119148932	3	3	79	1	0	0	0	0	1	0	0	0	2700	1702	59	5	1182	5	CBL	11	119148932	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	50971407	119148932	15857584	51	5344											
APOF	319	broad.mit.edu	37	chr12	56755294	56755294	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agacccataggcccccctgaCatcccagccatggtcatcag	8	17	2	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr12:56755294C>A	uc001sle.1	-	2	750	c.696G>T	c.(694-696)ATG>ATT	p.M232I		NM_001638	NP_001629	Q13790	APOF_HUMAN	apolipoprotein F precursor	232					cholesterol metabolic process	high-density lipoprotein particle|low-density lipoprotein particle	cholesterol binding|lipid transporter activity|receptor binding				0						GCCCCCCTGACATCCCAGCCA	0.517													A	56755294	A	A	56755294	3	1	79	1	0	0	0	0	1	0	0	0	803	478	17	5	288	5	APOF	12	56755294	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08		56755294	77096601	52	5345											
CAPS2	84698	broad.mit.edu	37	chr12	75678781	75678781	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtattcattcatttcaccaAtaataccacgtttgaattct	3	9	4	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr12:75678781A>G	uc001sxk.3	-	16	1729	c.1532T>C	c.(1531-1533)ATT>ACT	p.I511T	CAPS2_uc001sxm.3_Missense_Mutation_p.I279T|CAPS2_uc009zsa.2_Missense_Mutation_p.I101T|CAPS2_uc001sxi.3_Missense_Mutation_p.I247T|CAPS2_uc001sxj.3_Missense_Mutation_p.I422T|CAPS2_uc001sxl.3_Missense_Mutation_p.I492T	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	511	EF-hand 2.						calcium ion binding			ovary(2)	2						CATTTCACCAATAATACCACG	0.313													G	75678781	G	G	75678781	3	3	79	1	0	0	0	0	1	0	0	0	2638	101	4	4	153	4	CAPS2	12	75678781	Missense_Mutation	SNP	A	TCGA-06-2562-01A-01D-1494-08	18923487	75678781	58173114	53	5346											
TDG	6996	broad.mit.edu	37	chr12	104378553	104378553	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tatgttatgccatcatccagTgcaagatgtgctcagtttcc	8	10	2	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr12:104378553T>A	uc001tkg.2	+	8	1042	c.819T>A	c.(817-819)AGT>AGA	p.S273R	TDG_uc009zuk.2_Missense_Mutation_p.S269R|TDG_uc010swi.1_Missense_Mutation_p.S130R|TDG_uc010swj.1_Missense_Mutation_p.S61R	NM_003211	NP_003202	Q13569	TDG_HUMAN	thymine-DNA glycosylase	273					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			ovary(3)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(302;0.00114)		CATCATCCAGTGCAAGATGTG	0.338								BER_DNA_glycosylases					A	104378553	A	A	104378553	3	1	79	1	0	0	0	0	1	0	0	0	15722	1693	59	5	849	5	TDG	12	104378553	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	28699772	104378553	29473342	54	5347											
TMEM132D	121256	broad.mit.edu	37	chr12	129558525	129558525	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcatcctcgctactcatcacGatggagttcctggtggggta	11	11	3	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr12:129558525G>A	uc009zyl.1	-	9	3523	c.3195C>T	c.(3193-3195)ATC>ATT	p.I1065I	TMEM132D_uc001uia.2_Silent_p.I603I	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	1065	Cytoplasmic (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TACTCATCACGATGGAGTTCC	0.517													A	129558525	A	A	129558525	2	1	79	1	0	0	0	0	0	0	0	1	16044	1048	37	2		2	TMEM132D	12	129558525	Silent	SNP	G	TCGA-06-2562-01A-01D-1494-08	25179972	129558525	4293370	55	5348											
EFNB2	1948	broad.mit.edu	37	chr13	107187195	107187195	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgcggacgccacttacttggAgttcgaggaattccaataga	11	10	0	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr13:107187195A>C	uc001vqi.2	-	1	143	c.118T>G	c.(118-120)TCC>GCC	p.S40A		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	40	Extracellular (Potential).				cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					ACTTACTTGGAGTTCGAGGAA	0.433													C	107187195	C	C	107187195	3	2	79	1	0	0	0	0	1	0	0	0	4956	304	11	5	903	5	EFNB2	13	107187195	Missense_Mutation	SNP	A	TCGA-06-2562-01A-01D-1494-08		107187195	7982683	56	5349											
COL4A2	1284	broad.mit.edu	37	chr13	111134945	111134945	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtttccagggagcaaaggCgaggctggatttttcggaat	16	6	0	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr13:111134945C>T	uc001vqx.2	+	32	3130	c.2841C>T	c.(2839-2841)GGC>GGT	p.G947G		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	947	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGAGCAAAGGCGAGGCTGGAT	0.527													T	111134945	T	T	111134945	2	4	79	1	0	0	0	0	0	0	0	1	3690	755	27	1		1	COL4A2	13	111134945	Silent	SNP	C	TCGA-06-2562-01A-01D-1494-08	3947750	111134945	4034933	57	5350											
KLHL28	54813	broad.mit.edu	37	chr14	45415013	45415013	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gaattttaacatcacctactCgaagaatgatgtcacagagt	7	8	2	3			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr14:45415013C>A	uc001wvq.2	-	2	365	c.119G>T	c.(118-120)CGA>CTA	p.R40L	KLHL28_uc001wvr.2_Missense_Mutation_p.R40L|KLHL28_uc001wvt.3_Missense_Mutation_p.R40L	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	40	BTB.									ovary(1)	1						ATCACCTACTCGAAGAATGAT	0.428													A	45415013	A	A	45415013	3	1	79	1	0	0	0	0	1	0	0	0	8382	884	31	5	1612	5	KLHL28	14	45415013	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08		45415013	61934527	58	5351											
DLGAP5	9787	broad.mit.edu	37	chr14	55650334	55650334	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	taaaagaaaacaaggcatatCaggtctataacgacccactt	6	9	2	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr14:55650334C>G	uc001xbs.2	-	3	593	c.376G>C	c.(376-378)GAT>CAT	p.D126H	DLGAP5_uc001xbt.2_Missense_Mutation_p.D126H	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	126					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						CAAGGCATATCAGGTCTATAA	0.323													G	55650334	G	G	55650334	3	3	79	1	0	0	0	0	1	0	0	0	4563	826	29	5	2327	5	DLGAP5	14	55650334	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	10235321	55650334	51699206	59	5352											
KCNK10	54207	broad.mit.edu	37	chr14	88654322	88654322	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggtcctacctcttcttttgTctttttggacagaacccgta	8	11	3	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr14:88654322T>C	uc001xwo.2	-	6	1442	c.985A>G	c.(985-987)ACA>GCA	p.T329A	KCNK10_uc001xwm.2_Missense_Mutation_p.T334A|KCNK10_uc001xwn.2_Missense_Mutation_p.T334A	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	329	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						TCTTCTTTTGTCTTTTTGGAC	0.493													C	88654322	C	C	88654322	3	2	79	1	0	0	0	0	1	0	0	0	8059	1667	58	4	639	4	KCNK10	14	88654322	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	33003988	88654322	18695218	60	5353											
C15orf52	388115	broad.mit.edu	37	chr15	40629935	40629935	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccacccacgtggacttggCcttgtccaggtcccacgggc	12	16	0	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr15:40629935C>T	uc001zlh.3	-	6	821	c.805G>A	c.(805-807)GCC>ACC	p.A269T	C15orf52_uc001zli.1_Missense_Mutation_p.A201T|C15orf52_uc010ucn.1_Missense_Mutation_p.A59T	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	269										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GTGGACTTGGCCTTGTCCAGG	0.701													T	40629935	T	T	40629935	3	4	79	1	0	0	0	0	1	0	0	0	1800	739	26	3	823	3	C15orf52	15	40629935	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08		40629935	61901457	61	5354											
CYP11A1	1583	broad.mit.edu	37	chr15	74636252	74636252	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtggaacatctggtagatgGcatcaatgaatcgctgggcc	13	8	2	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr15:74636252G>A	uc002axt.2	-	4	862	c.707C>T	c.(706-708)GCC>GTC	p.A236V	CYP11A1_uc002axs.2_Missense_Mutation_p.A78V|CYP11A1_uc010bjm.1_Missense_Mutation_p.A78V|CYP11A1_uc010bjn.1_Intron|CYP11A1_uc010bjo.1_Missense_Mutation_p.A236V|CYP11A1_uc010bjp.1_RNA|CYP11A1_uc010ulj.1_Missense_Mutation_p.A16V	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	236					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	CTGGTAGATGGCATCAATGAA	0.572													A	74636252	A	A	74636252	3	1	79	1	0	0	0	0	1	0	0	0	4144	1203	42	3	882	3	CYP11A1	15	74636252	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	34006317	74636252	27895140	62	5355											
HAPLN3	145864	broad.mit.edu	37	chr15	89421300	89421300	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggggcccacagttaggatgCgggtgaaccacagggtagcg	18	9	0	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr15:89421300C>T	uc002bnc.2	-	5	1112	c.984G>A	c.(982-984)CCG>CCA	p.P328P	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Silent_p.P390P	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	328	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					AGTTAGGATGCGGGTGAACCA	0.642													T	89421300	T	T	89421300	2	4	79	1	0	0	0	0	0	0	0	1	6956	755	27	1		1	HAPLN3	15	89421300	Silent	SNP	C	TCGA-06-2562-01A-01D-1494-08	14785048	89421300	13110092	63	5356											
CASKIN1	57524	broad.mit.edu	37	chr16	2231462	2231462	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggccggtgtgggctcaggcGggggcggcgactcgatggcc	21	12	1	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr16:2231462G>A	uc010bsg.1	-	18	1939	c.1907C>T	c.(1906-1908)CCG>CTG	p.P636L		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	636					signal transduction	cytoplasm				skin(2)	2						GGGCTCAGGCGGGGGCGGCGA	0.657													A	2231462	A	A	2231462	3	1	79	1	0	0	0	0	1	0	0	0	2666	1116	39	2	2400	2	CASKIN1	16	2231462	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08		2231462	88123291	64	5357											
DNAH3	55567	broad.mit.edu	37	chr16	21080807	21080807	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccctcttctggcatctgggCtatgatgtcctctgaactga	9	13	4	3			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr16:21080807C>T	uc010vbe.1	-	23	3310	c.3310G>A	c.(3310-3312)GCC>ACC	p.A1104T		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1104	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GGCATCTGGGCTATGATGTCC	0.428													T	21080807	T	T	21080807	3	4	79	1	0	0	0	0	1	0	0	0	4603	797	28	3	9199	3	DNAH3	16	21080807	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	18849345	21080807	69273946	65	5358											
ITGAX	3687	broad.mit.edu	37	chr16	31382999	31382999	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggccctcgaccctggccGcctgagtccccgtgccacct	10	21	0	1	rs146647978	byFrequency	TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr16:31382999G>A	uc002ebu.1	+	17	2121	c.2054G>A	c.(2053-2055)CGC>CAC	p.R685H	ITGAX_uc002ebt.2_Missense_Mutation_p.R685H	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	685	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GACCCTGGCCGCCTGAGTCCC	0.607													A	31382999	A	A	31382999	3	1	79	1	0	0	0	0	1	0	0	0	7889	1087	38	1	2120	1	ITGAX	16	31382999	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	10302192	31382999	58971754	66	5359											
PDP2	57546	broad.mit.edu	37	chr16	66918530	66918530	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtttgagagcaaccagctgGctgccaattccccagtggag	13	11	0	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr16:66918530G>A	uc002eqk.1	+	2	505	c.343G>A	c.(343-345)GCT>ACT	p.A115T		NM_020786	NP_065837	Q9P2J9	PDP2_HUMAN	pyruvate dehydrogenase phosphatase isoenzyme 2	115					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		CAACCAGCTGGCTGCCAATTC	0.522													A	66918530	A	A	66918530	3	1	79	1	0	0	0	0	1	0	0	0	11686	1203	42	3	345	3	PDP2	16	66918530	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	35535531	66918530	23436223	67	5360											
NF1	4763	broad.mit.edu	37	chr17	29541476	29541476	+	Frame_Shift_Del	DEL	C	-	-													gttttgtttttagagtcttaCatttaaagaaaaagtaacaa							TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr17:29541476delC	uc002hgg.2	+	13	1733	c.1400delC	c.(1399-1401)ACAfs	p.T467fs	NF1_uc002hge.1_Frame_Shift_Del_p.T467fs|NF1_uc002hgf.1_Frame_Shift_Del_p.T467fs|NF1_uc002hgh.2_Frame_Shift_Del_p.T467fs|NF1_uc010csn.1_Frame_Shift_Del_p.T327fs	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	467					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TAGAGTCTTACATTTAAAGAA	0.289			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29541476	-	-	29541476	7	5	79	1	0	1	0	1	0	0	0	0	10356	478	17	0	1450	0	NF1	17	29541476	Frame_Shift_Del	DEL	C	TCGA-06-2562-01A-01D-1494-08		29541476	51653734	68	5361											
NF1	4763	broad.mit.edu	37	chr17	29652976	29652979	+	Frame_Shift_Del	DEL	TCTC	-	-													aatcgctttaaaacagacttTctctctaagtggtttgttgt							TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr17:29652976_29652979delTCTC	uc002hgg.2	+	37	5307_5310	c.4974_4977delTCTC	c.(4972-4977)TTTCTCfs	p.F1658fs	NF1_uc002hgh.2_Frame_Shift_Del_p.F1637fs|NF1_uc002hgi.1_Frame_Shift_Del_p.F670fs|NF1_uc010cso.2_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1658_1659	CRAL-TRIO.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.S1660fs*37(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AAACAGACTTTCTCTCTAAGTGGT	0.422			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29652979	-	-	29652976	7	5	79	1	0	1	0	1	0	0	0	0	10356	1780	62	0	5181	0	NF1	17	29652976	Frame_Shift_Del	DEL	TCTC	TCGA-06-2562-01A-01D-1494-08	111500	29652976	51542234	69	5362											
RNF43	54894	broad.mit.edu	37	chr17	56435337	56435337	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaggggctgctgagttggaTctggtgacttgctgatcagg	17	6	2	3			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr17:56435337T>G	uc002iwf.2	-	8	3756	c.1800A>C	c.(1798-1800)AGA>AGC	p.R600S	RNF43_uc010wnv.1_Missense_Mutation_p.R559S|RNF43_uc002iwh.3_Missense_Mutation_p.R600S|RNF43_uc002iwg.3_Missense_Mutation_p.R600S|RNF43_uc010dcw.2_Missense_Mutation_p.R473S	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	600	Pro-rich.|Cytoplasmic (Potential).			R -> G (in Ref. 1; BAD51435 and 2; BAA91085).		endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGAGTTGGATCTGGTGACTT	0.657													G	56435337	G	G	56435337	3	3	79	1	0	0	0	0	1	0	0	0	13495	1432	50	5	559	5	RNF43	17	56435337	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	26782361	56435337	24759873	70	5363											
RGS9	8787	broad.mit.edu	37	chr17	63173876	63173876	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggacaatgtgctggactaCggcctggaccgagtgaccaa	13	10	0	1	rs61739619		TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr17:63173876C>T	uc002jfe.2	+	9	719	c.609C>T	c.(607-609)TAC>TAT	p.Y203Y	RGS9_uc010dem.2_Silent_p.Y203Y|RGS9_uc002jfd.2_Silent_p.Y203Y|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	203					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						TGCTGGACTACGGCCTGGACC	0.488													T	63173876	T	T	63173876	2	4	79	1	0	0	0	0	0	0	0	1	13313	547	19	1		1	RGS9	17	63173876	Silent	SNP	C	TCGA-06-2562-01A-01D-1494-08	6738539	63173876	18021334	71	5364											
CDH7	1005	broad.mit.edu	37	chr18	63489429	63489429	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggaggactgtcaggaactacAtcagtcactgtgaccctaac	10	11	3	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr18:63489429A>G	uc002ljz.2	+	5	1063	c.738A>G	c.(736-738)ACA>ACG	p.T246T	CDH7_uc002lka.2_Silent_p.T246T|CDH7_uc002lkb.2_Silent_p.T246T	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	246	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CAGGAACTACATCAGTCACTG	0.433													G	63489429	G	G	63489429	2	3	79	1	0	0	0	0	0	0	0	1	3115	204	8	4		4	CDH7	18	63489429	Silent	SNP	A	TCGA-06-2562-01A-01D-1494-08		63489429	14587819	72	5365											
ZNF407	55628	broad.mit.edu	37	chr18	72775604	72775604	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcaggagattttaaacctctCggaggctggagtcgctcccc	12	12	1	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr18:72775604C>T	uc002llw.2	+	8	5984	c.5927C>T	c.(5926-5928)TCG>TTG	p.S1976L		NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1976					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TTAAACCTCTCGGAGGCTGGA	0.617													T	72775604	T	T	72775604	3	4	79	1	0	0	0	0	1	0	0	0	17884	893	31	2	6087	2	ZNF407	18	72775604	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08	9286175	72775604	5301644	73	5366											
ZNF77	58492	broad.mit.edu	37	chr19	2933851	2933851	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagtatgcgtcctcacgtggAttcgaagggaggaggaaaaa	14	7	1	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr19:2933851A>G	uc002lws.3	-	4	1405	c.1274T>C	c.(1273-1275)ATC>ACC	p.I425T		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	425	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCACGTGGATTCGAAGGGA	0.502													G	2933851	G	G	2933851	3	3	79	1	0	0	0	0	1	0	0	0	18139	333	12	4	367	4	ZNF77	19	2933851	Missense_Mutation	SNP	A	TCGA-06-2562-01A-01D-1494-08		2933851	56195132	74	5367											
MAG	4099	broad.mit.edu	37	chr19	35804318	35804318	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggacagctacacgctgacGgaggagctagctgagtatgc	14	9	0	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr19:35804318G>A	uc002nyy.1	+	11	1991	c.1842G>A	c.(1840-1842)ACG>ACA	p.T614T	MAG_uc002nyx.1_3'UTR|MAG_uc010eds.1_Silent_p.T589T|MAG_uc002nyz.1_Silent_p.T614T	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	614	Cytoplasmic (Potential).			T -> S (in Ref. 2).	blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			ACACGCTGACGGAGGAGCTAG	0.657													A	35804318	A	A	35804318	2	1	79	1	0	0	0	0	0	0	0	1	9162	1103	39	2		2	MAG	19	35804318	Silent	SNP	G	TCGA-06-2562-01A-01D-1494-08	32870467	35804318	23324665	75	5368											
IL4I1	259307	broad.mit.edu	37	chr19	50392981	50392981	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agagataactggccttggacTggagggtggctgccttcttc	14	9	1	1			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr19:50392981T>G	uc002pqt.1	-	8	1728	c.1650A>C	c.(1648-1650)CCA>CCC	p.P550P	IL4I1_uc002pqv.1_Silent_p.P559P|IL4I1_uc010eno.1_Silent_p.P558P|IL4I1_uc002pqw.1_Silent_p.P558P|IL4I1_uc002pqu.1_Silent_p.P572P	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	550						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		GGCCTTGGACTGGAGGGTGGC	0.602													G	50392981	G	G	50392981	2	3	79	1	0	0	0	0	0	0	0	1	7697	1567	55	5		5	IL4I1	19	50392981	Silent	SNP	T	TCGA-06-2562-01A-01D-1494-08	14588663	50392981	8736002	76	5369											
PLCB1	23236	broad.mit.edu	37	chr20	8628555	8628559	+	Frame_Shift_Del	DEL	AACTT	-	-													cttctccaacagctatactaAacttaagctgcaagtcactc							TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr20:8628555_8628559delAACTT	uc002wnb.2	+	6	476_480	c.473_477delAACTT	c.(472-477)AAACTTfs	p.K158fs	PLCB1_uc010zrb.1_Frame_Shift_Del_p.K57fs|PLCB1_uc010gbv.1_Frame_Shift_Del_p.K158fs|PLCB1_uc002wmz.1_Frame_Shift_Del_p.K158fs|PLCB1_uc002wna.2_Frame_Shift_Del_p.K158fs|PLCB1_uc002wnc.1_Frame_Shift_Del_p.K57fs	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	158_159					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AGCTATACTAAACTTAAGCTGCAAG	0.259													-	8628559	-	-	8628555	7	5	79	1	0	1	0	1	0	0	0	0	12027	14	1	0	495	0	PLCB1	20	8628555	Frame_Shift_Del	DEL	AACTT	TCGA-06-2562-01A-01D-1494-08		8628555	54396965	77	5370											
SSTR4	6754	broad.mit.edu	37	chr20	23016341	23016341	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcatcttcgtgatccttcGctacgccaagatgaagacgg	11	11	2	4			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr20:23016341G>A	uc002wsr.2	+	1	285	c.221G>A	c.(220-222)CGC>CAC	p.R74H		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	74	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GTGATCCTTCGCTACGCCAAG	0.557													A	23016341	A	A	23016341	3	1	79	1	0	0	0	0	1	0	0	0	15199	1087	38	1	223	1	SSTR4	20	23016341	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	14387786	23016341	40009179	78	5371											
EIF2S2	8894	broad.mit.edu	37	chr20	32677582	32677582	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcttgcccgtgacagccTggaagccggttttgatactg	12	12	0	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr20:32677582T>C	uc002xaf.2	-	9	1125	c.956A>G	c.(955-957)CAG>CGG	p.Q319R	EIF2S2_uc002xag.2_Missense_Mutation_p.Q316R|EIF2S2_uc010ges.2_Missense_Mutation_p.Q259R	NM_003908	NP_003899	P20042	IF2B_HUMAN	eukaryotic translation initiation factor 2 beta	319						cytosol|eukaryotic translation initiation factor 2 complex	metal ion binding|protein binding|translation initiation factor activity			large_intestine(1)	1						CGTGACAGCCTGGAAGCCGGT	0.483													C	32677582	C	C	32677582	3	2	79	1	0	0	0	0	1	0	0	0	5010	1580	55	4	49	4	EIF2S2	20	32677582	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	9661241	32677582	30347938	79	5372											
SLC12A5	57468	broad.mit.edu	37	chr20	44673744	44673744	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccccacgcctgctgcagGccatctcgagggatggcatt	14	14	1	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr20:44673744G>A	uc010zxl.1	+	12	1679	c.1603G>A	c.(1603-1605)GCC>ACC	p.A535T	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.A512T	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	535					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCTGCTGCAGGCCATCTCGAG	0.632													A	44673744	A	A	44673744	3	1	79	1	0	0	0	0	1	0	0	0	14386	1203	42	3	1705	3	SLC12A5	20	44673744	Missense_Mutation	SNP	G	TCGA-06-2562-01A-01D-1494-08	11996162	44673744	18351776	80	5373											
TUBB1	81027	broad.mit.edu	37	chr20	57599544	57599544	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgtcaaggtggctgtctgCgacatcccgccccgggggct	14	14	2	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr20:57599544C>T	uc002yak.2	+	4	1331	c.1062C>T	c.(1060-1062)TGC>TGT	p.C354C		NM_030773	NP_110400	Q9H4B7	TBB1_HUMAN	beta tubulin 1, class VI	354					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			ovary(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	TGGCTGTCTGCGACATCCCGC	0.567													T	57599544	T	T	57599544	2	4	79	1	0	0	0	0	0	0	0	1	16750	776	27	1		1	TUBB1	20	57599544	Silent	SNP	C	TCGA-06-2562-01A-01D-1494-08	12925800	57599544	5425976	81	5374											
DGCR8	54487	broad.mit.edu	37	chr22	20074008	20074008	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttggtgacggggtaggcatAgggggtgagagtgctgataa	20	3	0	3			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr22:20074008A>G	uc002zri.2	+	2	872	c.522A>G	c.(520-522)ATA>ATG	p.I174M	DGCR8_uc010grz.2_Missense_Mutation_p.I174M|DGCR8_uc002zrj.2_5'Flank	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	174	Necessary for nuclear localization and retention.|Necessary for interaction with NCL.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					GGGTAGGCATAGGGGGTGAGA	0.552													G	20074008	G	G	20074008	3	3	79	1	0	0	0	0	1	0	0	0	4464	410	15	4	524	4	DGCR8	22	20074008	Missense_Mutation	SNP	A	TCGA-06-2562-01A-01D-1494-08		20074008	31230558	82	5375											
LZTR1	8216	broad.mit.edu	37	chr22	21340179	21340179	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcgatgtgaaagactgctccTggtgcaggtgggtggccccg	16	10	0	2			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chr22:21340179T>C	uc002zto.2	+	3	416	c.313T>C	c.(313-315)TGG>CGG	p.W105R	LZTR1_uc002ztn.2_Missense_Mutation_p.W64R|LZTR1_uc011ahy.1_Intron|LZTR1_uc010gsr.1_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	105	Kelch 1.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity	p.W105L(1)		ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			AGACTGCTCCTGGTGCAGGTG	0.582													C	21340179	C	C	21340179	3	2	79	1	0	0	0	0	1	0	0	0	9137	1580	55	4	323	4	LZTR1	22	21340179	Missense_Mutation	SNP	T	TCGA-06-2562-01A-01D-1494-08	1266171	21340179	29964387	83	5376											
EDA	1896	broad.mit.edu	37	chrX	69253319	69253319	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtgtttaagctacatcccCgcagcggggagctggaggta	15	9	0	0			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chrX:69253319C>T	uc004dxs.2	+	7	1107	c.865C>T	c.(865-867)CGC>TGC	p.R289C	EDA_uc004dxr.2_Missense_Mutation_p.R289C|EDA_uc011mpj.1_Missense_Mutation_p.R286C	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	289	Extracellular (Potential).				cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						GCTACATCCCCGCAGCGGGGA	0.498											OREG0019847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	69253319	T	T	69253319	3	4	79	1	0	0	0	0	1	0	0	0	4903	652	23	2	1027	2	EDA	23	69253319	Missense_Mutation	SNP	C	TCGA-06-2562-01A-01D-1494-08		69253319	86017241	84	5377											
MCF2	4168	broad.mit.edu	37	chrX	138679647	138679647	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catttattgcaatctgatgcAtagaatcattaactgacttc	5	8	2	3			TCGA-06-2562-01A-01D-1494-08	TCGA-06-2562-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6cb3467e-0ad8-4dd9-8b9b-9103629fd16f	a99131bf-78b4-404b-9146-032998b71c38	g.chrX:138679647A>G	uc004fau.2	-	18	2321	c.2027T>C	c.(2026-2028)ATG>ACG	p.M676T	MCF2_uc004fav.2_Missense_Mutation_p.M692T|MCF2_uc011mwl.1_Missense_Mutation_p.M653T|MCF2_uc010nsh.1_Missense_Mutation_p.M676T|MCF2_uc011mwm.1_Missense_Mutation_p.M637T|MCF2_uc011mwn.1_Missense_Mutation_p.M821T|MCF2_uc004faw.2_Missense_Mutation_p.M736T|MCF2_uc011mwo.1_Missense_Mutation_p.M752T	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	676					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity	p.M676I(1)		lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					AATCTGATGCATAGAATCATT	0.259													G	138679647	G	G	138679647	3	3	79	1	0	0	0	0	1	0	0	0	9378	217	8	4	810	4	MCF2	23	138679647	Missense_Mutation	SNP	A	TCGA-06-2562-01A-01D-1494-08	69426328	138679647	16590913	85	5378											
PLCH2	9651	broad.mit.edu	37	chr1	2411404	2411404	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcctggctcgccgccagcGcaccagggaccaatatcctt	10	17	0	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:2411404G>A	uc001aji.1	+	3	777	c.503G>A	c.(502-504)CGC>CAC	p.R168H	PLCH2_uc010nyz.1_5'Flank|PLCH2_uc009vle.1_5'Flank|PLCH2_uc001ajj.1_5'Flank|PLCH2_uc001ajk.1_5'Flank	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	168					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CGCCGCCAGCGCACCAGGGAC	0.687													A	2411404	A	A	2411404	3	1	80	1	0	0	0	0	1	0	0	0	12038	1087	38	1	513	1	PLCH2	1	2411404	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08		2411404	246839217	1	5379											
NCDN	23154	broad.mit.edu	37	chr1	36028235	36028235	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggccaggagacgctctccgGtgagtctgtagttacagtct	13	10	3	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:36028235G>A	uc001bza.2	+	5	1512	c.1385_splice	c.e5+1	p.R462_splice	NCDN_uc001bzb.2_Splice_Site_p.R462_splice|NCDN_uc001bzc.2_Splice_Site_p.R445_splice	NM_001014839	NP_001014839	Q9UBB6	NCDN_HUMAN	neurochondrin isoform 1						neuron projection development	cytosol|dendrite|neuronal cell body				large_intestine(2)|pancreas(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACGCTCTCCGGTGAGTCTGTA	0.597													A	36028235	A	A	36028235	5	1	80	1	0	0	0	0	0	0	1	0	10214	1275	44	3	1400	3	NCDN	1	36028235	Splice_Site	SNP	G	TCGA-06-2563-01A-01D-1494-08	33616831	36028235	213222386	2	5380											
KIAA0754	643314	broad.mit.edu	37	chr1	39876294	39876294	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgtgccacccagaaggcgGccaaatgcagaacgcaaaga	11	13	0	3			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:39876294G>A	uc009vvt.1	+	1	1119	c.357G>A	c.(355-357)CGG>CGA	p.R119R	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	Error:Variant_position_missing_in_O94854_after_alignment											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCAGAAGGCGGCCAAATGCAG	0.478													A	39876294	A	A	39876294	2	1	80	1	0	0	0	0	0	0	0	1	8192	1190	42	3		3	KIAA0754	1	39876294	Silent	SNP	G	TCGA-06-2563-01A-01D-1494-08	3848059	39876294	209374327	3	5381											
C1orf173	127254	broad.mit.edu	37	chr1	75108729	75108729	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accttaaacctctggattcgCtccttcctagctaaggtctc	6	14	2	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:75108729C>A	uc001dgg.2	-	4	516	c.297G>T	c.(295-297)GAG>GAT	p.E99D		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	99										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCTGGATTCGCTCCTTCCTAG	0.323													A	75108729	A	A	75108729	3	1	80	1	0	0	0	0	1	0	0	0	2014	796	28	5	4339	5	C1orf173	1	75108729	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	35232435	75108729	174141892	4	5382											
ZZZ3	26009	broad.mit.edu	37	chr1	78098001	78098001	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaggttctccggaggctgGcatactctcaagacttgtgt	11	10	3	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:78098001G>A	uc001dhq.2	-	5	1515	c.1039C>T	c.(1039-1041)CCA>TCA	p.P347S	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.P347S|ZZZ3_uc001dhp.2_Missense_Mutation_p.P347S	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						CCGGAGGCTGGCATACTCTCA	0.443													A	78098001	A	A	78098001	3	1	80	1	0	0	0	0	1	0	0	0	18253	1203	42	3	1716	3	ZZZ3	1	78098001	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	2989272	78098001	171152620	5	5383											
ANKRD35	148741	broad.mit.edu	37	chr1	145558841	145558841	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacaatctgtgcaggatggaCgtacacccctgatgatcgca	10	11	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:145558841C>T	uc001eob.1	+	7	568	c.460C>T	c.(460-462)CGT>TGT	p.R154C	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Translation_Start_Site	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	154	ANK 4.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCAGGATGGACGTACACCCCT	0.557													T	145558841	T	T	145558841	3	4	80	1	0	0	0	0	1	0	0	0	664	536	19	1	486	1	ANKRD35	1	145558841	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	67460840	145558841	103691780	6	5384											
SPRR1A	6698	broad.mit.edu	37	chr1	152957774	152957774	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcagcagcagcaggtgaaacAaccttgccagcctccacccc	8	17	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:152957774A>T	uc009wnu.1	+	2	146	c.68A>T	c.(67-69)CAA>CTA	p.Q23L	SPRR1A_uc001faw.2_Missense_Mutation_p.Q23L	NM_005987	NP_005978	P35321	SPR1A_HUMAN	small proline-rich protein 1A	23	2.|2 X 12 AA approximate repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity				0	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGGTGAAACAACCTTGCCAG	0.572													T	152957774	T	T	152957774	3	4	80	1	0	0	0	0	1	0	0	0	15094	130	5	5	70	5	SPRR1A	1	152957774	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08	7398933	152957774	96292847	7	5385											
C1orf116	79098	broad.mit.edu	37	chr1	207195575	207195575	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatcttgtccaagaaggagcCctttcccagagaagtgctgg	12	10	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:207195575C>T	uc001hfd.2	-	4	1793	c.1534G>A	c.(1534-1536)GGC>AGC	p.G512S	C1orf116_uc009xcb.1_Missense_Mutation_p.G266S	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	512						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					AAGAAGGAGCCCTTTCCCAGA	0.567													T	207195575	T	T	207195575	3	4	80	1	0	0	0	0	1	0	0	0	1989	623	22	3	275	3	C1orf116	1	207195575	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	54237801	207195575	42055046	8	5386											
HIST3H3	8290	broad.mit.edu	37	chr1	228612678	228612678	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttaggcatgatggtgacccGtttggcatggatgacacaca	12	9	0	3			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:228612678G>A	uc001hsx.1	-	1	349	c.349C>T	c.(349-351)CGG>TGG	p.R117W		NM_003493	NP_003484	Q16695	H31T_HUMAN	histone cluster 3, H3	117					nucleosome assembly|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		Prostate(94;0.0724)				ATGGTGACCCGTTTGGCATGG	0.627													A	228612678	A	A	228612678	3	1	80	1	0	0	0	0	1	0	0	0	7184	1144	40	1	65	1	HIST3H3	1	228612678	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	21417103	228612678	20637943	9	5387											
HIST3H2A	92815	broad.mit.edu	37	chr1	228645127	228645127	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ccgggggcggcgggcggcctCacttgcccttggccttgtgg	18	14	1	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:228645127C>T	uc001hsy.2	-	1	434	c.392G>A	c.(391-393)TGA>TAA	p.*131*	HIST3H2BB_uc001hsz.2_5'Flank	NM_033445	NP_254280	Q7L7L0	H2A3_HUMAN	histone cluster 3, H2a	131					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1		Prostate(94;0.183)				cgggcggccTCACTTGCCCTT	0.502													T	228645127	T	T	228645127	2	4	80	1	0	0	0	0	0	0	0	1	7182	837	29	3		3	HIST3H2A	1	228645127	Silent	SNP	C	TCGA-06-2563-01A-01D-1494-08	32449	228645127	20605494	10	5388											
OR2C3	81472	broad.mit.edu	37	chr1	247695195	247695195	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccccagaggcaggacaacaaAgacaaagctggccaggtaca	11	12	0	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr1:247695195A>G	uc009xgy.2	-	2	981	c.619T>C	c.(619-621)TTT>CTT	p.F207L	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			AGGACAACAAAGACAAAGCTG	0.532													G	247695195	G	G	247695195	3	3	80	1	0	0	0	0	1	0	0	0	10993	72	3	4	347	4	OR2C3	1	247695195	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08	19050068	247695195	1555426	11	5389											
RNF181	51255	broad.mit.edu	37	chr2	85824255	85824255	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcccttgtgccgctatgAgctgcccactgatgacgaca	10	14	0	3			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr2:85824255A>G	uc002spv.1	+	4	406	c.356A>G	c.(355-357)GAG>GGG	p.E119G		NM_016494	NP_057578	Q9P0P0	RN181_HUMAN	ring finger protein 181	119							ligase activity|zinc ion binding				0						TGCCGCTATGAGCTGCCCACT	0.522													G	85824255	G	G	85824255	3	3	80	1	0	0	0	0	1	0	0	0	13465	304	11	4	370	4	RNF181	2	85824255	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08		85824255	157375118	12	5390											
ANAPC1	64682	broad.mit.edu	37	chr2	112608407	112608407	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttggagtactaacgccatcTagtggagtactgggccgagg	14	8	1	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr2:112608407T>A	uc002thi.2	-	14	1843	c.1596A>T	c.(1594-1596)CTA>CTT	p.L532L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	532					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						TAACGCCATCTAGTGGAGTAC	0.433													A	112608407	A	A	112608407	2	1	80	1	0	0	0	0	0	0	0	1	598	1509	53	5		5	ANAPC1	2	112608407	Silent	SNP	T	TCGA-06-2563-01A-01D-1494-08	26784152	112608407	130590966	13	5391											
LY75	4065	broad.mit.edu	37	chr2	160755444	160755444	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggagtgcaaatgaaagagcCgatgctgggacacccacttc	13	10	0	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr2:160755444C>T	uc002ubc.3	-	2	290	c.221G>A	c.(220-222)CGG>CAG	p.R74Q	LY75_uc002ubb.3_Missense_Mutation_p.R74Q|LY75_uc010fos.2_Missense_Mutation_p.R74Q|LY75_uc010fot.1_Missense_Mutation_p.R74Q	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	74	Extracellular (Potential).|Ricin B-type lectin.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		ATGAAAGAGCCGATGCTGGGA	0.493													T	160755444	T	T	160755444	3	4	80	1	0	0	0	0	1	0	0	0	9099	652	23	2	5083	2	LY75	2	160755444	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	48147037	160755444	82443929	14	5392											
TRIP12	9320	broad.mit.edu	37	chr2	230663714	230663714	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttccccatgtttttggattcAagcttgccaggaaagaagat	9	8	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr2:230663714A>C	uc002vpw.1	-	22	3243	c.3134T>G	c.(3133-3135)TTG>TGG	p.L1045W	TRIP12_uc002vpx.1_Missense_Mutation_p.L1093W|TRIP12_uc002vpy.1_Missense_Mutation_p.L775W|TRIP12_uc010zlz.1_RNA	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1045					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TTTTGGATTCAAGCTTGCCAG	0.448													C	230663714	C	C	230663714	3	2	80	1	0	0	0	0	1	0	0	0	16553	131	5	5	2924	5	TRIP12	2	230663714	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08	69908270	230663714	12535659	15	5393			1	19		3	3	50	N	T_A	1.016105e-08
TRIP12	9320	broad.mit.edu	37	chr2	230663734	230663734	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagcttgccaggaaagaagaTttaggtgactgagtagtggt	14	4	0	4			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr2:230663734T>C	uc002vpw.1	-	22	3223	c.3114A>G	c.(3112-3114)AAA>AAG	p.K1038K	TRIP12_uc002vpx.1_Silent_p.K1086K|TRIP12_uc002vpy.1_Silent_p.K768K|TRIP12_uc010zlz.1_RNA	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1038					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GGAAAGAAGATTTAGGTGACT	0.398													C	230663734	C	C	230663734	2	2	80	1	0	0	0	0	0	0	0	1	16553	1490	52	4		4	TRIP12	2	230663734	Silent	SNP	T	TCGA-06-2563-01A-01D-1494-08	20	230663734	12535639	16	5394			1	19		3	3	50	N	T_A	1.016105e-08
TRIP12	9320	broad.mit.edu	37	chr2	230663763	230663763	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgagtagtggtggggctttTagctatgaaaagaaaaaaga	13	3	0	4			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr2:230663763T>C	uc002vpw.1	-	22	3194	c.3085A>G	c.(3085-3087)AAA>GAA	p.K1029E	TRIP12_uc002vpx.1_Missense_Mutation_p.K1077E|TRIP12_uc002vpy.1_Missense_Mutation_p.K759E|TRIP12_uc010zlz.1_RNA	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1029					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GTGGGGCTTTTAGCTATGAAA	0.343													C	230663763	C	C	230663763	3	2	80	1	0	0	0	0	1	0	0	0	16553	1763	61	4	2973	4	TRIP12	2	230663763	Missense_Mutation	SNP	T	TCGA-06-2563-01A-01D-1494-08	29	230663763	12535610	17	5395			1	19		3	3	50	N	T_A	1.016105e-08
GRIP2	80852	broad.mit.edu	37	chr3	14558595	14558595	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agctcttgtgttcccttcttCgctgcctcctccgccccatt	6	18	2	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr3:14558595C>T	uc011avi.1	-	12	1577	c.1577G>A	c.(1576-1578)CGA>CAA	p.R526Q	GRIP2_uc011avh.1_Missense_Mutation_p.R57Q	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	428					synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						TTCCCTTCTTCGCTGCCTCCT	0.572													T	14558595	T	T	14558595	3	4	80	1	0	0	0	0	1	0	0	0	6788	884	31	2	1903	2	GRIP2	3	14558595	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08		14558595	183463835	18	5396											
TLR9	54106	broad.mit.edu	37	chr3	52255367	52255367	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccagaggaggacactctggcGgcagaggcgctggcgcagcc	17	13	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr3:52255367G>T	uc003dda.1	-	2	3599	c.2965C>A	c.(2965-2967)CGC>AGC	p.R989S	TLR9_uc003ddb.2_Missense_Mutation_p.R1086S	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	989	TIR.|Cytoplasmic (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	ACACTCTGGCGGCAGAGGCGC	0.687													T	52255367	T	T	52255367	3	4	80	1	0	0	0	0	1	0	0	0	15955	1116	39	5	137	5	TLR9	3	52255367	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	37696772	52255367	145767063	19	5397											
TNIP3	79931	broad.mit.edu	37	chr4	122075742	122075742	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atttcacattcgtaatgttcCttttccttgttcgcaagagt	6	9	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr4:122075742C>G	uc010ing.2	-	5	652	c.456G>C	c.(454-456)AAG>AAC	p.K152N	TNIP3_uc010inh.2_Missense_Mutation_p.K152N|TNIP3_uc011cgj.1_Missense_Mutation_p.K210N|TNIP3_uc010ini.2_Missense_Mutation_p.K152N	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	152	Potential.									ovary(1)	1						CGTAATGTTCCTTTTCCTTGT	0.343													G	122075742	G	G	122075742	3	3	80	1	0	0	0	0	1	0	0	0	16313	680	24	5	549	5	TNIP3	4	122075742	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08		122075742	69078534	20	5398											
BRD9	65980	broad.mit.edu	37	chr5	865623	865623	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tccgcctgtgcttcgtgcagGtcctgcaggagcttcgtcgt	13	13	0	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr5:865623G>C	uc003jbq.2	-	15	1766	c.1599C>G	c.(1597-1599)GAC>GAG	p.D533E	BRD9_uc003jbl.2_Missense_Mutation_p.D417E|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Missense_Mutation_p.D480E|BRD9_uc003jbo.2_Missense_Mutation_p.D437E	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	533							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			CTTCGTGCAGGTCCTGCAGGA	0.617													C	865623	C	C	865623	3	2	80	1	0	0	0	0	1	0	0	0	1507	1252	44	5	202	5	BRD9	5	865623	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08		865623	180049637	21	5399											
MARVELD2	153562	broad.mit.edu	37	chr5	68728420	68728420	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttcaaggaactgagaacaGcaaaaatgaaacctgaacta	7	7	1	3			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr5:68728420G>A	uc003jwq.2	+	4	1308	c.1249G>A	c.(1249-1251)GCA>ACA	p.A417T	MARVELD2_uc010ixf.2_Missense_Mutation_p.A405T|MARVELD2_uc003jwr.1_Missense_Mutation_p.A417T|MARVELD2_uc003jws.1_RNA	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	417	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		ACTGAGAACAGCAAAAATGAA	0.448													A	68728420	A	A	68728420	3	1	80	1	0	0	0	0	1	0	0	0	9318	971	34	3	1259	3	MARVELD2	5	68728420	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	67862797	68728420	112186840	22	5400											
SLCO6A1	133482	broad.mit.edu	37	chr5	101816005	101816005	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	actttttttctgtctccataGaatgctataaatattgctac	4	8	2	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr5:101816005G>T	uc003knn.2	-	2	664	c.492C>A	c.(490-492)TTC>TTA	p.F164L	SLCO6A1_uc003kno.2_Missense_Mutation_p.F164L|SLCO6A1_uc003knp.2_Missense_Mutation_p.F164L|SLCO6A1_uc003knq.2_Missense_Mutation_p.F164L	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	164	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TGTCTCCATAGAATGCTATAA	0.338													T	101816005	T	T	101816005	3	4	80	1	0	0	0	0	1	0	0	0	14732	933	33	5	1715	5	SLCO6A1	5	101816005	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	33087585	101816005	79099255	23	5401											
CHSY3	337876	broad.mit.edu	37	chr5	129519964	129519964	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attatgaacacaatcggaagGgttacatccaagaccttcac	7	10	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr5:129519964G>A	uc003kvd.2	+	3	1129	c.1129G>A	c.(1129-1131)GGT>AGT	p.G377S		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	377	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		CAATCGGAAGGGTTACATCCA	0.338													A	129519964	A	A	129519964	3	1	80	1	0	0	0	0	1	0	0	0	3413	1232	43	3	1139	3	CHSY3	5	129519964	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	27703959	129519964	51395296	24	5402											
FBXO38	81545	broad.mit.edu	37	chr5	147784293	147784293	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatcccaatgctaaggcaccTttatatgaagtgggtaagac	9	8	0	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr5:147784293T>G	uc003lpf.1	+	6	758	c.638T>G	c.(637-639)CTT>CGT	p.L213R	FBXO38_uc003lpg.1_Missense_Mutation_p.L213R|FBXO38_uc003lph.2_Missense_Mutation_p.L213R	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	213						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTAAGGCACCTTTATATGAAG	0.348													G	147784293	G	G	147784293	3	3	80	1	0	0	0	0	1	0	0	0	5746	1609	56	5	656	5	FBXO38	5	147784293	Missense_Mutation	SNP	T	TCGA-06-2563-01A-01D-1494-08	18264329	147784293	33130967	25	5403											
SLIT3	6586	broad.mit.edu	37	chr5	168212916	168212916	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaagttcctactcacagcaGctgtagggacaccagcccat	8	14	1	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr5:168212916G>A	uc003mab.2	-	12	1567	c.1147C>T	c.(1147-1149)CTG>TTG	p.L383L	SLIT3_uc010jjg.2_Silent_p.L383L|SLIT3_uc010jji.2_Silent_p.L383L|SLIT3_uc003mac.1_Silent_p.L180L	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	383	LRR 10.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTCACAGCAGCTGTAGGGAC	0.493													A	168212916	A	A	168212916	2	1	80	1	0	0	0	0	0	0	0	1	14741	962	34	3		3	SLIT3	5	168212916	Silent	SNP	G	TCGA-06-2563-01A-01D-1494-08	20428623	168212916	12702344	26	5404											
NSD1	64324	broad.mit.edu	37	chr5	176638305	176638305	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacacaattcagagaaaaagGgagatggcactcagaactcc	9	10	2	3			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr5:176638305G>A	uc003mfr.3	+	5	3043	c.2905G>A	c.(2905-2907)GGA>AGA	p.G969R	NSD1_uc003mft.3_Missense_Mutation_p.G700R|NSD1_uc003mfs.1_Missense_Mutation_p.G866R|NSD1_uc011dfx.1_Missense_Mutation_p.G617R	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	969					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGAGAAAAAGGGAGATGGCAC	0.512			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			A	176638305	A	A	176638305	3	1	80	1	0	0	0	0	1	0	0	0	10669	1233	43	3	2919	3	NSD1	5	176638305	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	8425389	176638305	4276955	27	5405											
PNPLA1	285848	broad.mit.edu	37	chr6	36259268	36259268	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccatgtgagcctcacccGcttaacggacggggagaatg	13	12	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr6:36259268G>A	uc010jwf.2	+	2	377	c.377G>A	c.(376-378)CGC>CAC	p.R126H	PNPLA1_uc003olw.1_Missense_Mutation_p.R31H|PNPLA1_uc010jwe.1_Missense_Mutation_p.R31H	NM_001145717	NP_001139189	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	126	Patatin.				lipid catabolic process		hydrolase activity			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4						AGCCTCACCCGCTTAACGGAC	0.602													A	36259268	A	A	36259268	3	1	80	1	0	0	0	0	1	0	0	0	12164	1087	38	1	383	1	PNPLA1	6	36259268	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08		36259268	134855799	28	5406											
PRICKLE4	29964	broad.mit.edu	37	chr6	41753983	41753983	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttatgccctgcctgggggaAgcccctgctgccccagctgc	13	16	0	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr6:41753983A>G	uc011duf.1	+	7	948	c.700A>G	c.(700-702)AGC>GGC	p.S234G	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_5'Flank|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	194	LIM zinc-binding 2.					nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCCTGGGGGAAGCCCCTGCTG	0.672													G	41753983	G	G	41753983	3	3	80	1	0	0	0	0	1	0	0	0	12489	72	3	4	718	4	PRICKLE4	6	41753983	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08	5494715	41753983	129361084	29	5407											
TIAM2	26230	broad.mit.edu	37	chr6	155572049	155572049	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctgtttttacaatctaggtAacagaactttcgatgggaga	9	7	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr6:155572049A>C	uc003qqb.2	+	24	5227	c.3954A>C	c.(3952-3954)GTA>GTC	p.V1318V	TIAM2_uc003qqe.2_Silent_p.V1318V|TIAM2_uc010kjj.2_Silent_p.V880V|TIAM2_uc003qqf.2_Silent_p.V694V|TIAM2_uc011efl.1_Silent_p.V654V|TIAM2_uc003qqg.2_Silent_p.V630V|TIAM2_uc003qqh.2_Silent_p.V243V	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1318					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CAATCTAGGTAACAGAACTTT	0.423													C	155572049	C	C	155572049	2	2	80	1	0	0	0	0	0	0	0	1	15888	349	13	5		5	TIAM2	6	155572049	Silent	SNP	A	TCGA-06-2563-01A-01D-1494-08	113818066	155572049	15543018	30	5408											
HECW1	23072	broad.mit.edu	37	chr7	43485067	43485067	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acccggagtccacgaacggcGctgggccgtggcaagacgag	16	13	0	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr7:43485067G>A	uc003tid.1	+	11	2901	c.2296G>A	c.(2296-2298)GCT>ACT	p.A766T	HECW1_uc011kbi.1_Missense_Mutation_p.A766T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	766					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CACGAACGGCGCTGGGCCGTG	0.652													A	43485067	A	A	43485067	3	1	80	1	0	0	0	0	1	0	0	0	7042	1087	38	1	2330	1	HECW1	7	43485067	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08		43485067	115653596	31	5409											
ZPBP	11055	broad.mit.edu	37	chr7	50121433	50121433	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctatcagttcagcatttcGcagttgttgcgttacacata	8	9	3	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr7:50121433G>A	uc003tou.2	-	3	341	c.271C>T	c.(271-273)CGA>TGA	p.R91*	ZPBP_uc011kci.1_Nonsense_Mutation_p.R17*|ZPBP_uc010kyw.2_Nonsense_Mutation_p.R91*	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	91					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					TCAGCATTTCGCAGTTGTTGC	0.338													A	50121433	A	A	50121433	4	1	80	1	0	0	0	0	0	1	0	0	18216	1095	38	1	808	1	ZPBP	7	50121433	Nonsense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	6636366	50121433	109017230	32	5410											
EGFR	1956	broad.mit.edu	37	chr7	55221710	55221710	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctctcctccataggtctgcCgcaaattccgagacgaagcc	8	15	2	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr7:55221710C>T	uc003tqk.2	+	7	1000	c.754C>T	c.(754-756)CGC>TGC	p.R252C	EGFR_uc003tqh.2_Missense_Mutation_p.R252C|EGFR_uc003tqi.2_Missense_Mutation_p.R252C|EGFR_uc003tqj.2_Missense_Mutation_p.R252C|EGFR_uc010kzg.1_Missense_Mutation_p.R207C|EGFR_uc011kco.1_Missense_Mutation_p.R199C|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	252	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.R252C(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATAGGTCTGCCGCAAATTCCG	0.582		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221710	T	T	55221710	3	4	80	1	0	0	0	0	1	0	0	0	4967	652	23	2	780	2	EGFR	7	55221710	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	5100277	55221710	103916953	33	5411											
CCDC146	57639	broad.mit.edu	37	chr7	76922321	76922321	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aactgagaaaatgatggctcTtgttgctgagctgtccatga	11	7	1	4			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr7:76922321T>C	uc003uga.2	+	18	2595	c.2468T>C	c.(2467-2469)CTT>CCT	p.L823P	CCDC146_uc010ldp.2_Missense_Mutation_p.L537P|CCDC146_uc003ugc.2_Missense_Mutation_p.L160P	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	823	Potential.									ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				ATGATGGCTCTTGTTGCTGAG	0.398													C	76922321	C	C	76922321	3	2	80	1	0	0	0	0	1	0	0	0	2780	1609	56	4	2534	4	CCDC146	7	76922321	Missense_Mutation	SNP	T	TCGA-06-2563-01A-01D-1494-08	21700611	76922321	82216342	34	5412											
PCLO	27445	broad.mit.edu	37	chr7	82387898	82387898	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagacatgtttcttcaatgcGtttgagtaggactgaccaaa	9	7	2	3			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr7:82387898G>A	uc003uhx.2	-	25	15711	c.15422C>T	c.(15421-15423)ACG>ATG	p.T5141M		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	5064					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCTTCAATGCGTTTGAGTAGG	0.378													A	82387898	A	A	82387898	3	1	80	1	0	0	0	0	1	0	0	0	11583	1145	40	1	10	1	PCLO	7	82387898	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	5465577	82387898	76750765	35	5413											
SLC26A3	1811	broad.mit.edu	37	chr7	107427951	107427951	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttgtgagaatacagagtataGtacctacaattataaaaaca	6	5	0	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr7:107427951G>C	uc003ver.2	-	7	950	c.739C>G	c.(739-741)CTA>GTA	p.L247V	SLC26A3_uc003ves.2_Missense_Mutation_p.L212V	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	247					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						ACAGAGTATAGTACCTACAAT	0.323													C	107427951	C	C	107427951	3	2	80	1	0	0	0	0	1	0	0	0	14518	1020	36	5	1615	5	SLC26A3	7	107427951	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	25040053	107427951	51710712	36	5414											
KEL	3792	broad.mit.edu	37	chr7	142649696	142649696	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagaaagggtcaccaccagcCctaagatcatgtggctctgc	11	12	3	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr7:142649696C>A	uc003wcb.2	-	10	1313	c.1103G>T	c.(1102-1104)GGG>GTG	p.G368V		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	368	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					CACCACCAGCCCTAAGATCAT	0.537													A	142649696	A	A	142649696	3	1	80	1	0	0	0	0	1	0	0	0	8142	623	22	5	1135	5	KEL	7	142649696	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	35221745	142649696	16488967	37	5415											
KCNH2	3757	broad.mit.edu	37	chr7	150649545	150649545	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agagccgaagatgagcaggtCgaaggggatggcggccacca	17	9	0	3			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr7:150649545C>T	uc003wic.2	-	6	1538	c.1525G>A	c.(1525-1527)GAC>AAC	p.D509N	KCNH2_uc003wib.2_Missense_Mutation_p.D169N|KCNH2_uc011kux.1_Missense_Mutation_p.D413N|KCNH2_uc003wid.2_Missense_Mutation_p.D169N|KCNH2_uc003wie.2_Missense_Mutation_p.D509N	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	509	Helical; Name=Segment S3; (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	ATGAGCAGGTCGAAGGGGATG	0.632													T	150649545	T	T	150649545	3	4	80	1	0	0	0	0	1	0	0	0	8032	884	31	2	2263	2	KCNH2	7	150649545	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	7999849	150649545	8489118	38	5416											
CYP7B1	9420	broad.mit.edu	37	chr8	65517309	65517309	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggctaccaagtctccctttCgcacacagtagtccccggtc	8	16	1	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr8:65517309C>T	uc003xvj.2	-	5	1367	c.1163G>A	c.(1162-1164)CGA>CAA	p.R388Q		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	388					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				GTCTCCCTTTCGCACACAGTA	0.453													T	65517309	T	T	65517309	3	4	80	1	0	0	0	0	1	0	0	0	4197	884	31	2	365	2	CYP7B1	8	65517309	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08		65517309	80846713	39	5417											
RIMS2	9699	broad.mit.edu	37	chr8	104922392	104922392	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttacaactggttggatcataCgtcttggcatagcagtgagg	12	7	2	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr8:104922392C>T	uc003yls.2	+	3	1230	c.989C>T	c.(988-990)ACG>ATG	p.T330M	RIMS2_uc003ylp.2_Missense_Mutation_p.T552M|RIMS2_uc003ylw.2_Missense_Mutation_p.T360M|RIMS2_uc003ylq.2_Missense_Mutation_p.T360M|RIMS2_uc003ylr.2_Intron|RIMS2_uc003ylt.2_5'Flank	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TTGGATCATACGTCTTGGCAT	0.388										HNSCC(12;0.0054)			T	104922392	T	T	104922392	3	4	80	1	0	0	0	0	1	0	0	0	13368	536	19	1	1799	1	RIMS2	8	104922392	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	39405083	104922392	41441630	40	5418											
CSMD3	114788	broad.mit.edu	37	chr8	113988286	113988286	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctggatacagtaacatctgcAggtgtgctagcaacagcaat	10	9	1	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr8:113988286A>T	uc003ynu.2	-	7	1281	c.1122T>A	c.(1120-1122)CCT>CCA	p.P374P	CSMD3_uc003ynt.2_Silent_p.P334P|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	374	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAACATCTGCAGGTGTGCTAG	0.493										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			T	113988286	T	T	113988286	2	4	80	1	0	0	0	0	0	0	0	1	3946	175	7	5		5	CSMD3	8	113988286	Silent	SNP	A	TCGA-06-2563-01A-01D-1494-08	9065894	113988286	32375736	41	5419											
COL14A1	7373	broad.mit.edu	37	chr8	121326264	121326264	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctgtccattcaaggaatgCccgtgagttgtgttcaaaca	10	9	3	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr8:121326264C>T	uc003yox.2	+	38	4814	c.4549C>T	c.(4549-4551)CCC>TCC	p.P1517S	COL14A1_uc003yoz.2_Missense_Mutation_p.P482S	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1517	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCAAGGAATGCCCGTGAGTTG	0.468													T	121326264	T	T	121326264	3	4	80	1	0	0	0	0	1	0	0	0	3671	739	26	3	4695	3	COL14A1	8	121326264	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	7337978	121326264	25037758	42	5420											
IDE	3416	broad.mit.edu	37	chr10	94267958	94267958	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccaccaacaagagtattaacCcagcctgcaacattcaaagg	6	13	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr10:94267958C>G	uc001kia.2	-	8	1141	c.1065G>C	c.(1063-1065)TGG>TGC	p.W355C		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	355					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAGTATTAACCCAGCCTGCAA	0.358													G	94267958	G	G	94267958	3	3	80	1	0	0	0	0	1	0	0	0	7493	624	22	5	2066	5	IDE	10	94267958	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08		94267958	41266789	43	5421											
SLK	9748	broad.mit.edu	37	chr10	105762134	105762134	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgtggaggatattaatgaaCatattaccgatgctcagtta	9	6	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr10:105762134C>A	uc001kxo.1	+	9	1232	c.1198C>A	c.(1198-1200)CAT>AAT	p.H400N	SLK_uc001kxp.1_Missense_Mutation_p.H400N	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	400	Glu-rich.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TATTAATGAACATATTACCGA	0.388													A	105762134	A	A	105762134	3	1	80	1	0	0	0	0	1	0	0	0	14748	478	17	5	1232	5	SLK	10	105762134	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	11494176	105762134	29772613	44	5422											
SIRT3	23410	broad.mit.edu	37	chr11	233173	233173	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atggcctcggggtacgggagAtcgtactgctggaggttgct	17	8	0	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr11:233173A>C	uc001lok.3	-	3	550	c.516T>G	c.(514-516)GAT>GAG	p.D172E	SIRT3_uc001loj.3_Missense_Mutation_p.D30E|SIRT3_uc010qvm.1_Missense_Mutation_p.D108E|SIRT3_uc010qvn.1_Missense_Mutation_p.D91E|SIRT3_uc010qvo.1_Missense_Mutation_p.D172E|SIRT3_uc010qvp.1_Missense_Mutation_p.D172E|SIRT3_uc010qvq.1_Missense_Mutation_p.D30E|SIRT3_uc009ybt.1_RNA	NM_012239	NP_036371	Q9NTG7	SIRT3_HUMAN	sirtuin 3 isoform a	172	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			urinary_tract(1)	1		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		GGTACGGGAGATCGTACTGCT	0.532													C	233173	C	C	233173	3	2	80	1	0	0	0	0	1	0	0	0	14339	330	12	5	703	5	SIRT3	11	233173	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08		233173	134773343	45	5423											
OR51M1	390059	broad.mit.edu	37	chr11	5411176	5411176	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ggcttttccctactgtggatCtgtggtcctctcccactcat	8	14	3	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr11:5411176C>G	uc010qzc.1	+	1	548	c.548C>G	c.(547-549)TCT>TGT	p.S183C	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	183						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACTGTGGATCTGTGGTCCTC	0.517													G	5411176	G	G	5411176	3	3	80	1	0	0	0	0	1	0	0	0	11103	913	32	5	550	5	OR51M1	11	5411176	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	5178003	5411176	129595340	46	5424											
VWCE	220001	broad.mit.edu	37	chr11	61048379	61048379	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcggggggactcagggccCctgggtgaggaaggggtccc	20	10	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr11:61048379C>T	uc001nra.2	-	8	1395	c.1116G>A	c.(1114-1116)AGG>AGA	p.R372R	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	372						extracellular region	calcium ion binding			ovary(1)	1						ACTCAGGGCCCCTGGGTGAGG	0.677													T	61048379	T	T	61048379	2	4	80	1	0	0	0	0	0	0	0	1	17242	622	22	3		3	VWCE	11	61048379	Silent	SNP	C	TCGA-06-2563-01A-01D-1494-08	55637203	61048379	73958137	47	5425											
SCNN1A	6337	broad.mit.edu	37	chr12	6463925	6463925	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgggcctcacctgctgtgtGtactttgaagggtaaaggtt	13	7	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr12:6463925G>T	uc001qnx.2	-	7	1522	c.1233C>A	c.(1231-1233)TAC>TAA	p.Y411*	SCNN1A_uc001qnv.2_Nonsense_Mutation_p.Y111*|SCNN1A_uc001qnw.2_Nonsense_Mutation_p.Y470*|SCNN1A_uc010sfb.1_Nonsense_Mutation_p.Y434*	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	411	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	CCTGCTGTGTGTACTTTGAAG	0.557													T	6463925	T	T	6463925	4	4	80	1	0	0	0	0	0	1	0	0	13927	1372	48	5	804	5	SCNN1A	12	6463925	Nonsense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08		6463925	127387970	48	5426											
CLEC1A	51267	broad.mit.edu	37	chr12	10224014	10224014	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccttctctcacagacacaaCgcttcaattctttgcagtcc	4	16	4	1	rs147882348	by1000genomes	TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr12:10224014C>T	uc001qxb.2	-	6	845	c.761G>A	c.(760-762)CGT>CAT	p.R254H	CLEC1A_uc009zhf.2_Missense_Mutation_p.R166H|CLEC1A_uc001qxc.2_Missense_Mutation_p.R166H|CLEC1A_uc001qxd.2_Missense_Mutation_p.R211H|CLEC1A_uc010sgx.1_Missense_Mutation_p.R152H	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1	254	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2						ACAGACACAACGCTTCAATTC	0.488													T	10224014	T	T	10224014	3	4	80	1	0	0	0	0	1	0	0	0	3505	536	19	1	85	1	CLEC1A	12	10224014	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	3760089	10224014	123627881	49	5427											
KRT18	3875	broad.mit.edu	37	chr12	53343221	53343221	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaccatgcaaagcctgaaCgaccgcctggcctcttacct	9	15	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr12:53343221C>T	uc001sbe.2	+	2	333	c.264C>T	c.(262-264)AAC>AAT	p.N88N	KRT18_uc009zmn.1_Silent_p.N88N|KRT18_uc001sbf.1_Translation_Start_Site|KRT18_uc001sbg.2_Silent_p.N88N|KRT18_uc009zmo.2_Silent_p.N88N|KRT8_uc009zml.1_Intron|KRT8_uc009zmm.1_Intron	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	88	Coil 1A.|Rod.|Interaction with TRADD.|Necessary for interaction with PNN.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						AAAGCCTGAACGACCGCCTGG	0.647													T	53343221	T	T	53343221	2	4	80	1	0	0	0	0	0	0	0	1	8455	535	19	1		1	KRT18	12	53343221	Silent	SNP	C	TCGA-06-2563-01A-01D-1494-08	43119207	53343221	80508674	50	5428											
PTPRR	5801	broad.mit.edu	37	chr12	71094985	71094985	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgagaccttgtgagaattcGgctggctgactgcagatact	12	9	0	4			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr12:71094985G>T	uc001swi.1	-	7	1542	c.1126C>A	c.(1126-1128)CGA>AGA	p.R376R	PTPRR_uc001swh.1_Silent_p.R131R|PTPRR_uc009zrs.2_Silent_p.R225R|PTPRR_uc010stq.1_Silent_p.R264R|PTPRR_uc010str.1_Silent_p.R225R	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	376	Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GTGAGAATTCGGCTGGCTGAC	0.458													T	71094985	T	T	71094985	2	4	80	1	0	0	0	0	0	0	0	1	12810	1124	39	5		5	PTPRR	12	71094985	Silent	SNP	G	TCGA-06-2563-01A-01D-1494-08	17751764	71094985	62756910	51	5429											
WSCD2	9671	broad.mit.edu	37	chr12	108600179	108600179	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaggacaactgtgctgaaCggtagggtcccagcatccca	12	13	0	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr12:108600179C>T	uc001tms.2	+	3	1240	c.496C>T	c.(496-498)CGG>TGG	p.R166W	WSCD2_uc001tmt.2_Missense_Mutation_p.R166W	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	166	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						CTGTGCTGAACGGTAGGGTCC	0.527													T	108600179	T	T	108600179	3	4	80	1	0	0	0	0	1	0	0	0	17404	550	19	1	502	1	WSCD2	12	108600179	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	37505194	108600179	25251716	52	5430											
TMEM132D	121256	broad.mit.edu	37	chr12	130184469	130184469	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccacgctgttgtccagaCgcagttctctcagggagggt	14	11	2	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr12:130184469C>T	uc009zyl.1	-	2	1182	c.854G>A	c.(853-855)CGT>CAT	p.R285H		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	285	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GTTGTCCAGACGCAGTTCTCT	0.522													T	130184469	T	T	130184469	3	4	80	1	0	0	0	0	1	0	0	0	16044	536	19	1	2477	1	TMEM132D	12	130184469	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	21584290	130184469	3667426	53	5431											
FAM70B	348013	broad.mit.edu	37	chr13	114502323	114502323	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tttctctaggaaccgaggccCctcaccacgggaagatgcca	10	14	2	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr13:114502323C>G	uc001vuh.2	+	5	381	c.354C>G	c.(352-354)CCC>CCG	p.P118P		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	118						integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			AACCGAGGCCCCTCACCACGG	0.542													G	114502323	G	G	114502323	2	3	80	1	0	0	0	0	0	0	0	1	5606	610	22	5		5	FAM70B	13	114502323	Silent	SNP	C	TCGA-06-2563-01A-01D-1494-08		114502323	667555	54	5432											
OR11H6	122748	broad.mit.edu	37	chr14	20692418	20692418	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctattgttcttatctcccaaCttcccttctgtgggcccaac	5	15	3	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr14:20692418C>A	uc010tlc.1	+	1	550	c.550C>A	c.(550-552)CTT>ATT	p.L184I		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		TATCTCCCAACTTCCCTTCTG	0.507													A	20692418	A	A	20692418	3	1	80	1	0	0	0	0	1	0	0	0	10929	565	20	5	552	5	OR11H6	14	20692418	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08		20692418	86657122	55	5433											
RPL10L	140801	broad.mit.edu	37	chr14	47120841	47120841	+	Frame_Shift_Del	DEL	G	-	-													ttctttctacccaggtcaaaGatgcggatcttggcatcagg							TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr14:47120841delG	uc001wwg.2	-	1	188	c.99delC	c.(97-99)ATCfs	p.I33fs		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	33					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						CCAGGTCAAAGATGCGGATCT	0.537													-	47120841	-	-	47120841	7	5	80	1	0	1	0	1	0	0	0	0	13556	932	33	0	549	0	RPL10L	14	47120841	Frame_Shift_Del	DEL	G	TCGA-06-2563-01A-01D-1494-08	26428423	47120841	60228699	56	5434											
MAPKBP1	23005	broad.mit.edu	37	chr15	42106769	42106769	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgcctcttctctggagtggcGaatgccaggtatccagacac	11	13	2	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr15:42106769G>A	uc001zok.3	+	11	1306	c.1020G>A	c.(1018-1020)GCG>GCA	p.A340A	MAPKBP1_uc001zoj.3_Silent_p.A334A|MAPKBP1_uc010bcj.2_Intron|MAPKBP1_uc010bci.2_Silent_p.A334A|MAPKBP1_uc010udb.1_Silent_p.A222A|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Intron	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	340										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CTGGAGTGGCGAATGCCAGGT	0.488													A	42106769	A	A	42106769	2	1	80	1	0	0	0	0	0	0	0	1	9292	1045	37	2		2	MAPKBP1	15	42106769	Silent	SNP	G	TCGA-06-2563-01A-01D-1494-08		42106769	60424623	57	5435											
MAPKBP1	23005	broad.mit.edu	37	chr15	42111074	42111074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccatcagcatgaggcagcGtctggccgagttgcgccagc	14	13	2	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr15:42111074G>A	uc001zok.3	+	21	2514	c.2228G>A	c.(2227-2229)CGT>CAT	p.R743H	MAPKBP1_uc001zoj.3_Missense_Mutation_p.R737H|MAPKBP1_uc010bcj.2_Missense_Mutation_p.R244H|MAPKBP1_uc010bci.2_Missense_Mutation_p.R737H|MAPKBP1_uc010udb.1_Missense_Mutation_p.R576H|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Missense_Mutation_p.R244H	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	743										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		ATGAGGCAGCGTCTGGCCGAG	0.602													A	42111074	A	A	42111074	3	1	80	1	0	0	0	0	1	0	0	0	9292	1145	40	1	2306	1	MAPKBP1	15	42111074	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	4305	42111074	60420318	58	5436											
ATP8B4	79895	broad.mit.edu	37	chr15	50339659	50339659	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttcgatgtgtggatacgattAtcctggaaaagaaatagcat	10	5	0	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr15:50339659A>T	uc001zxu.2	-	4	232	c.90T>A	c.(88-90)GAT>GAA	p.D30E	ATP8B4_uc010ber.2_5'UTR|ATP8B4_uc010ufd.1_5'UTR|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	30	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.D30D(1)		skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GGATACGATTATCCTGGAAAA	0.373													T	50339659	T	T	50339659	3	4	80	1	0	0	0	0	1	0	0	0	1197	446	16	5	3588	5	ATP8B4	15	50339659	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08	8228585	50339659	52191733	59	5437											
PTX4	390667	broad.mit.edu	37	chr16	1536134	1536134	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacgaaggcctcggagctgtCgaatccgccccccacgctgt	11	17	0	0	rs149572258		TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr16:1536134C>T	uc010uvf.1	-	3	1228	c.1228G>A	c.(1228-1230)GAC>AAC	p.D410N		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	415	Pentaxin.					extracellular region	metal ion binding				0						TCGGAGCTGTCGAATCCGCCC	0.652													T	1536134	T	T	1536134	3	4	80	1	0	0	0	0	1	0	0	0	12823	884	31	2	196	2	PTX4	16	1536134	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08		1536134	88818619	60	5438											
SRRM2	23524	broad.mit.edu	37	chr16	2817214	2817214	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccgcaccagcagccaaccttGccagcaggattcctgcagcc	9	18	0	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr16:2817214G>C	uc002crk.2	+	11	7234	c.6685G>C	c.(6685-6687)GCC>CCC	p.A2229P	SRRM2_uc002crj.1_Missense_Mutation_p.A2133P|SRRM2_uc002crl.1_Missense_Mutation_p.A2229P|SRRM2_uc010bsu.1_Missense_Mutation_p.A2133P	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2229	Ala-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGCCAACCTTGCCAGCAGGAT	0.612													C	2817214	C	C	2817214	3	2	80	1	0	0	0	0	1	0	0	0	15168	1319	46	5	6723	5	SRRM2	16	2817214	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	1281080	2817214	87537539	61	5439											
DNAH3	55567	broad.mit.edu	37	chr16	21033373	21033373	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caacaaatttacaatgaaggCgaccaaattccaggcagggc	9	10	0	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr16:21033373C>T	uc010vbe.1	-	40	5696	c.5696G>A	c.(5695-5697)CGC>CAC	p.R1899H		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1899	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ACAATGAAGGCGACCAAATTC	0.458													T	21033373	T	T	21033373	3	4	80	1	0	0	0	0	1	0	0	0	4603	768	27	1	6745	1	DNAH3	16	21033373	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	18216159	21033373	69321380	62	5440											
POLR2A	5430	broad.mit.edu	37	chr17	7404279	7404279	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtggtggagaatggggaGctgatcatgggcatcctgtg	19	5	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr17:7404279G>A	uc002ghf.3	+	12	2136	c.1902G>A	c.(1900-1902)GAG>GAA	p.E634E		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	634					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				agaatggggagctgatcatgg	0.393													A	7404279	A	A	7404279	2	1	80	1	0	0	0	0	0	0	0	1	12214	962	34	3		3	POLR2A	17	7404279	Silent	SNP	G	TCGA-06-2563-01A-01D-1494-08		7404279	73790931	63	5441											
TP53	7157	broad.mit.edu	37	chr17	7578541	7578541	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttggcaaaacatcttgttgAgggcaggggagtactgtagg	16	5	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr17:7578541A>G	uc002gim.2	-	5	583	c.389T>C	c.(388-390)CTC>CCC	p.L130P	TP53_uc002gig.1_Missense_Mutation_p.L130P|TP53_uc002gih.2_Missense_Mutation_p.L130P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.L130P|TP53_uc010cni.1_Missense_Mutation_p.L130P|TP53_uc002gij.2_Missense_Mutation_p.L130P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.L37P|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.L91P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	130	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> H (in sporadic cancers; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> I (in a sporadic cancer; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L130V(11)|p.L130F(7)|p.L130R(7)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.L130L(4)|p.L130H(3)|p.Y126_N131delYSPALN(3)|p.L130fs*19(2)|p.N131fs*27(2)|p.L130fs*41(2)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.A129_L130insXX(1)|p.A129_N131delALN(1)|p.L130P(1)|p.V73fs*9(1)|p.Y126fs*18(1)|p.L130fs*39(1)|p.L130fs*16(1)|p.A129_K132delALNK(1)|p.L130_M133delLNKM(1)|p.L130fs*40(1)|p.S127fs*36(1)|p.L130del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATCTTGTTGAGGGCAGGGGA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			G	7578541	G	G	7578541	3	3	80	1	0	0	0	0	1	0	0	0	16378	304	11	4	909	4	TP53	17	7578541	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08	174262	7578541	73616669	64	5442											
C17orf39	79018	broad.mit.edu	37	chr17	17943061	17943061	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgagtgtcccccgccggccGgtgcctccgctgcctccgcg	13	21	0	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr17:17943061G>A	uc002gsg.1	+	1	451	c.283G>A	c.(283-285)GGT>AGT	p.G95S	ATPAF2_uc002gsd.1_5'Flank|ATPAF2_uc002gse.1_5'Flank|ATPAF2_uc002gsf.1_5'Flank|ATPAF2_uc010vxf.1_5'Flank	NM_024052	NP_076957	Q8IVV7	CQ039_HUMAN	hypothetical protein LOC79018	95	Pro-rich.									skin(1)	1	all_neural(463;0.228)					CCCGCCGGCCGGTGCCTCCGC	0.766													A	17943061	A	A	17943061	3	1	80	1	0	0	0	0	1	0	0	0	1855	1116	39	2	285	2	C17orf39	17	17943061	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	10364520	17943061	63252149	65	5443											
KCNJ12	3768	broad.mit.edu	37	chr17	21319772	21319772	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gttcctgctgcccagcgccaActccttctgctacgagaacg	9	16	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr17:21319772A>T	uc002gyv.1	+	3	1823	c.1118A>T	c.(1117-1119)AAC>ATC	p.N373I		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	373	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCCAGCGCCAACTCCTTCTGC	0.622										Prostate(3;0.18)			T	21319772	T	T	21319772	3	4	80	1	0	0	0	0	1	0	0	0	8046	43	2	5	1120	5	KCNJ12	17	21319772	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08	3376711	21319772	59875438	66	5444											
ACACA	31	broad.mit.edu	37	chr17	35614745	35614745	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccaaacattcttattgctgCggaaatttagctcctgaact	6	11	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr17:35614745C>T	uc002hnm.2	-	14	1786	c.1595G>A	c.(1594-1596)CGC>CAC	p.R532H	ACACA_uc002hnk.2_Missense_Mutation_p.R454H|ACACA_uc002hnl.2_Missense_Mutation_p.R474H|ACACA_uc002hnn.2_Missense_Mutation_p.R532H|ACACA_uc002hno.2_Missense_Mutation_p.R569H|ACACA_uc010cuz.2_Missense_Mutation_p.R532H	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	532	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTTATTGCTGCGGAAATTTAG	0.413													T	35614745	T	T	35614745	3	4	80	1	0	0	0	0	1	0	0	0	106	768	27	1	5617	1	ACACA	17	35614745	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	14294973	35614745	45580465	67	5445											
KRT33A	3883	broad.mit.edu	37	chr17	39503142	39503142	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctccagggcattgaccgtgCgtctcagctcgatgatctcc	10	14	3	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr17:39503142C>T	uc002hwk.1	-	5	867	c.830G>A	c.(829-831)CGC>CAC	p.R277H		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	277	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				ATTGACCGTGCGTCTCAGCTC	0.582													T	39503142	T	T	39503142	3	4	80	1	0	0	0	0	1	0	0	0	8469	768	27	1	396	1	KRT33A	17	39503142	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	3888397	39503142	41692068	68	5446											
JUP	3728	broad.mit.edu	37	chr17	39681243	39681243	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatgcgcagagcctgttccGtctcaaacctttcaaaggaa	8	12	3	1	rs138005000	byFrequency	TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr17:39681243G>A	uc010wfs.1	-	6	1009	c.1001C>T	c.(1000-1002)ACG>ATG	p.T334M	KRT19_uc002hxd.3_Missense_Mutation_p.T171M	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	Error:Variant_position_missing_in_P14923_after_alignment					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		AGCCTGTTCCGTCTCAAACCT	0.587													A	39681243	A	A	39681243	3	1	80	1	0	0	0	0	1	0	0	0	7972	1145	40	1		1	JUP	17	39681243	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08	178101	39681243	41513967	69	5447											
EPN3	55040	broad.mit.edu	37	chr17	48614388	48614388	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggagcgcatggcactggaGggcatcggcattggcagtgg	18	8	0	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr17:48614388G>A	uc002ira.3	+	2	906	c.471G>A	c.(469-471)GAG>GAA	p.E157E	EPN3_uc010wms.1_Silent_p.E212E|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Silent_p.E157E	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	157						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			TGGCACTGGAGGGCATCGGCA	0.657													A	48614388	A	A	48614388	2	1	80	1	0	0	0	0	0	0	0	1	5187	991	35	3		3	EPN3	17	48614388	Silent	SNP	G	TCGA-06-2563-01A-01D-1494-08	8933145	48614388	32580822	70	5448											
APBA3	9546	broad.mit.edu	37	chr19	3759564	3759564	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggcgggacactcaccctccTggggggcagggtaggaagcc	18	12	1	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr19:3759564T>C	uc002lyp.1	-	3	788	c.611A>G	c.(610-612)CAG>CGG	p.Q204R		NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	204					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCACCCTCCTGGGGGGCAGG	0.632													C	3759564	C	C	3759564	3	2	80	1	0	0	0	0	1	0	0	0	758	1580	55	4	1152	4	APBA3	19	3759564	Missense_Mutation	SNP	T	TCGA-06-2563-01A-01D-1494-08		3759564	55369419	71	5449											
CLPP	8192	broad.mit.edu	37	chr19	6366351	6366351	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taacatctacgccaagcacaCcaaacagagcctgcaggtga	8	13	1	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr19:6366351C>T	uc002mem.1	+	5	761	c.638C>T	c.(637-639)ACC>ATC	p.T213I	CLPP_uc002men.1_Missense_Mutation_p.T15I	NM_006012	NP_006003	Q16740	CLPP_HUMAN	caseinolytic peptidase, ATP-dependent,	213					proteolysis	mitochondrial matrix	ATP binding|protein binding|serine-type endopeptidase activity			ovary(1)	1						GCCAAGCACACCAAACAGAGC	0.557													T	6366351	T	T	6366351	3	4	80	1	0	0	0	0	1	0	0	0	3552	507	18	3	656	3	CLPP	19	6366351	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	2606787	6366351	52762632	72	5450											
VAV1	7409	broad.mit.edu	37	chr19	6772889	6772889	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gccgcccagccaccgcgtgaCctgggatggggctcaggtgt	16	14	1	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr19:6772889C>A	uc002mfu.1	+	1	168	c.71C>A	c.(70-72)ACC>AAC	p.T24N	VAV1_uc010xjh.1_Missense_Mutation_p.T24N|VAV1_uc010dva.1_Missense_Mutation_p.T24N	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	24	CH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CACCGCGTGACCTGGGATGGG	0.662													A	6772889	A	A	6772889	3	1	80	1	0	0	0	0	1	0	0	0	17128	507	18	5	73	5	VAV1	19	6772889	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	406538	6772889	52356094	73	5451											
CYP4F8	11283	broad.mit.edu	37	chr19	15730340	15730340	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catagtcttctacaagacccTgaagccctggctgggtaagt	10	11	2	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr19:15730340T>C	uc002nbi.2	+	4	447	c.383T>C	c.(382-384)CTG>CCG	p.L128P	CYP4F8_uc010xoi.1_3'UTR|CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	128					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TACAAGACCCTGAAGCCCTGG	0.537													C	15730340	C	C	15730340	3	2	80	1	0	0	0	0	1	0	0	0	4191	1580	55	4	393	4	CYP4F8	19	15730340	Missense_Mutation	SNP	T	TCGA-06-2563-01A-01D-1494-08	8957451	15730340	43398643	74	5452											
PSG7	5676	broad.mit.edu	37	chr19	43433692	43433692	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tatagtttgtgacaccaaatAggtagagggtcctgttggtt	12	5	0	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr19:43433692A>T	uc002ovl.3	-	4	713	c.611T>A	c.(610-612)CTA>CAA	p.L204Q	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_5'Flank|PSG7_uc002out.1_Missense_Mutation_p.L23Q|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.L82Q	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	204	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GACACCAAATAGGTAGAGGGT	0.522													T	43433692	T	T	43433692	3	4	80	1	0	0	0	0	1	0	0	0	12660	420	15	5	664	5	PSG7	19	43433692	Missense_Mutation	SNP	A	TCGA-06-2563-01A-01D-1494-08	27703352	43433692	15695291	75	5453											
MYBPC2	4606	broad.mit.edu	37	chr19	50945481	50945481	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcctaccaagtggacagaggCaacaagatcaagttgatggt	12	8	1	3			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr19:50945481C>A	uc002psf.2	+	9	864	c.813C>A	c.(811-813)GGC>GGA	p.G271G		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	271	Ig-like C2-type 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TGGACAGAGGCAACAAGATCA	0.522													A	50945481	A	A	50945481	2	1	80	1	0	0	0	0	0	0	0	1	10012	697	25	5		5	MYBPC2	19	50945481	Silent	SNP	C	TCGA-06-2563-01A-01D-1494-08	7511789	50945481	8183502	76	5454											
TGM3	7053	broad.mit.edu	37	chr20	2298103	2298103	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	actacgaccccatgggaaacCccctggacaagggtagtgat	11	12	0	1	rs147913958		TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr20:2298103C>A	uc002wfx.3	+	7	1052	c.955C>A	c.(955-957)CCC>ACC	p.P319T		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	319					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	CATGGGAAACCCCCTGGACAA	0.507													A	2298103	A	A	2298103	3	1	80	1	0	0	0	0	1	0	0	0	15828	623	22	5	981	5	TGM3	20	2298103	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08		2298103	60727417	77	5455											
FAM65C	140876	broad.mit.edu	37	chr20	49221267	49221267	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgcccatagaaaacttgCccgtggggctgggtgacacc	13	12	0	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr20:49221267C>T	uc002xvm.2	-	12	1307	c.989G>A	c.(988-990)GGC>GAC	p.G330D	FAM65C_uc010zyt.1_Missense_Mutation_p.G334D|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.G330D	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	330										ovary(2)	2						AGAAAACTTGCCCGTGGGGCT	0.592													T	49221267	T	T	49221267	3	4	80	1	0	0	0	0	1	0	0	0	5601	739	26	3	1895	3	FAM65C	20	49221267	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	46923164	49221267	13804253	78	5456											
TRPM2	7226	broad.mit.edu	37	chr21	45789188	45789188	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatcggagtcgccacctggGgcactgtccaccgccgcgag	13	17	0	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr21:45789188G>A	uc002zet.1	+	6	946	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TRPM2_uc002zeu.1_Missense_Mutation_p.G245S|TRPM2_uc002zew.1_Missense_Mutation_p.G245S|TRPM2_uc010gpt.1_Missense_Mutation_p.G245S|TRPM2_uc002zex.1_Missense_Mutation_p.G31S	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	245	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CGCCACCTGGGGCACTGTCCA	0.667													A	45789188	A	A	45789188	3	1	80	1	0	0	0	0	1	0	0	0	16583	1232	43	3	751	3	TRPM2	21	45789188	Missense_Mutation	SNP	G	TCGA-06-2563-01A-01D-1494-08		45789188	2340707	79	5457											
ZBED4	9889	broad.mit.edu	37	chr22	50280049	50280049	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggccattaacgagatgtcCgtcgagtgtaacttccgaga	12	9	0	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chr22:50280049C>T	uc003bix.2	+	2	3209	c.2739C>T	c.(2737-2739)TCC>TCT	p.S913S		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	913						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		ACGAGATGTCCGTCGAGTGTA	0.587													T	50280049	T	T	50280049	2	4	80	1	0	0	0	0	0	0	0	1	17517	639	23	2		2	ZBED4	22	50280049	Silent	SNP	C	TCGA-06-2563-01A-01D-1494-08		50280049	1024517	80	5458											
CXorf23	256643	broad.mit.edu	37	chrX	19968952	19968952	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gccttctttcaatgtcatgtCgtaggtcatttggatctatt	8	8	5	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:19968952C>T	uc004czp.2	-	7	1664	c.1664G>A	c.(1663-1665)CGA>CAA	p.R555Q	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Missense_Mutation_p.R120Q|CXorf23_uc004czo.2_Missense_Mutation_p.R505Q	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	555						mitochondrion				lung(1)|skin(1)	2						AATGTCATGTCGTAGGTCATT	0.368													T	19968952	T	T	19968952	3	4	80	1	0	0	0	0	1	0	0	0	4103	884	31	2	404	2	CXorf23	23	19968952	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08		19968952	135301608	81	5459											
OPHN1	4983	broad.mit.edu	37	chrX	67421527	67421527	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcttccttctcacacagTacttcagtgttaagtccaag	6	13	3	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:67421527T>C	uc004dww.3	-	11	1253	c.959A>G	c.(958-960)TAC>TGC	p.Y320C	OPHN1_uc011mpg.1_Missense_Mutation_p.Y320C	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	320	PH.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						TCTCACACAGTACTTCAGTGT	0.418													C	67421527	C	C	67421527	3	2	80	1	0	0	0	0	1	0	0	0	10875	1638	57	4	1505	4	OPHN1	23	67421527	Missense_Mutation	SNP	T	TCGA-06-2563-01A-01D-1494-08	47452575	67421527	87849033	82	5460											
LPAR4	2846	broad.mit.edu	37	chrX	78011289	78011289	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctgaactgttgttttgaccCtttcatctattacttcaccc	4	12	4	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:78011289C>A	uc010nme.2	+	2	1328	c.923C>A	c.(922-924)CCT>CAT	p.P308H		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	308	Helical; Name=7; (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						TGTTTTGACCCTTTCATCTAT	0.418													A	78011289	A	A	78011289	3	1	80	1	0	0	0	0	1	0	0	0	8907	681	24	5	925	5	LPAR4	23	78011289	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	10589762	78011289	77259271	83	5461											
POF1B	79983	broad.mit.edu	37	chrX	84634326	84634326	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcgctcatacactacatttTtttctggaggctgctgggct	9	11	2	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:84634326T>C	uc004eer.2	-	2	280	c.134A>G	c.(133-135)AAA>AGA	p.K45R	POF1B_uc004ees.2_Missense_Mutation_p.K45R	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	45							actin binding				0						CACTACATTTTTTTCTGGAGG	0.577													C	84634326	C	C	84634326	3	2	80	1	0	0	0	0	1	0	0	0	12182	1841	64	4	1699	4	POF1B	23	84634326	Missense_Mutation	SNP	T	TCGA-06-2563-01A-01D-1494-08	6623037	84634326	70636234	84	5462											
GUCY2F	2986	broad.mit.edu	37	chrX	108673542	108673542	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aagatttctcataccatttcGaacacatcacttgctcttga	4	11	3	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:108673542G>A	uc004eod.3	-	8	2061	c.1785C>T	c.(1783-1785)TTC>TTT	p.F595F	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	595	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						ATACCATTTCGAACACATCAC	0.388													A	108673542	A	A	108673542	2	1	80	1	0	0	0	0	0	0	0	1	6898	1049	37	2		2	GUCY2F	23	108673542	Silent	SNP	G	TCGA-06-2563-01A-01D-1494-08	24039216	108673542	46597018	85	5463											
LAMP2	3920	broad.mit.edu	37	chrX	119565295	119565295	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgggcacaaggaagttgtcGtcatctgcactgcagtcttg	12	9	3	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:119565295G>A	uc004est.3	-	9	1296	c.1116C>T	c.(1114-1116)GAC>GAT	p.D372D	LAMP2_uc004ess.3_Intron|LAMP2_uc011mtz.1_Intron	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	372	Lumenal (Potential).|Second lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						GGAAGTTGTCGTCATCTGCAC	0.438													A	119565295	A	A	119565295	2	1	80	1	0	0	0	0	0	0	0	1	8618	1136	40	1		1	LAMP2	23	119565295	Silent	SNP	G	TCGA-06-2563-01A-01D-1494-08	10891753	119565295	35705265	86	5464											
GRIA3	2892	broad.mit.edu	37	chrX	122532507	122532507	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatacatctgcattgacacaCgacgcaatactggtcatagc	7	11	2	1	rs148850386	byFrequency	TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:122532507C>T	uc004etq.3	+	8	1226	c.933C>T	c.(931-933)CAC>CAT	p.H311H	GRIA3_uc004etr.3_Silent_p.H311H|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Silent_p.H295H	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	311	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	CATTGACACACGACGCAATAC	0.423													T	122532507	T	T	122532507	2	4	80	1	0	0	0	0	0	0	0	1	6769	535	19	1		1	GRIA3	23	122532507	Silent	SNP	C	TCGA-06-2563-01A-01D-1494-08	2967212	122532507	32738053	87	5465											
SMARCA1	6594	broad.mit.edu	37	chrX	128657225	128657225	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggtggcttcggtggccgcGgcggccgctccctcctcctg	16	17	0	0			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:128657225G>A	uc004eun.3	-	1	236	c.123C>T	c.(121-123)GCC>GCT	p.A41A	SMARCA1_uc004eup.3_Silent_p.A41A|SMARCA1_uc011muk.1_Silent_p.A41A|SMARCA1_uc011mul.1_Silent_p.A41A	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	41					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						CGGTGGCCGCGGCGGCCGCTC	0.667													A	128657225	A	A	128657225	2	1	80	1	0	0	0	0	0	0	0	1	14768	1103	39	2		2	SMARCA1	23	128657225	Silent	SNP	G	TCGA-06-2563-01A-01D-1494-08	6124718	128657225	26613335	88	5466											
ZNF280C	55609	broad.mit.edu	37	chrX	129370597	129370598	+	Frame_Shift_Del	DEL	TG	-	-													gaaggatgtttcaacacataTgaagtatttttcatacctac							TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:129370597_129370598delTG	uc004evm.2	-	7	663_664	c.509_510delCA	c.(508-510)TCAfs	p.S170fs	ZNF280C_uc010nrf.1_Frame_Shift_Del_p.S170fs	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	170	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						TCAACACATATGAAGTATTTTT	0.312													-	129370598	-	-	129370597	7	5	80	1	0	1	0	1	0	0	0	0	17813	1451	51	0	1755	0	ZNF280C	23	129370597	Frame_Shift_Del	DEL	TG	TCGA-06-2563-01A-01D-1494-08	713372	129370597	25899963	89	5467											
MAGEC1	9947	broad.mit.edu	37	chrX	140995644	140995644	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcctgtgagctccttcccCtcctccacttcatcgagtct	6	17	2	1			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:140995644C>T	uc004fbt.2	+	4	2740	c.2454C>T	c.(2452-2454)CCC>CCT	p.P818P	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	818							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCCTTCCCCTCCTCCACTT	0.557										HNSCC(15;0.026)			T	140995644	T	T	140995644	2	4	80	1	0	0	0	0	0	0	0	1	9180	668	24	3		3	MAGEC1	23	140995644	Silent	SNP	C	TCGA-06-2563-01A-01D-1494-08	11625047	140995644	14274916	90	5468											
AFF2	2334	broad.mit.edu	37	chrX	148035181	148035181	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttctggcagctccagcgaatCggagagcagctctgagtcgg	14	11	2	2			TCGA-06-2563-01A-01D-1494-08	TCGA-06-2563-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	1d81086c-bf8b-4459-abcf-1ff905c6bf74	ed0e22ef-1560-4911-b27c-76044ec96702	g.chrX:148035181C>T	uc004fcp.2	+	10	1948	c.1469C>T	c.(1468-1470)TCG>TTG	p.S490L	AFF2_uc004fcq.2_Missense_Mutation_p.S480L|AFF2_uc004fcr.2_Missense_Mutation_p.S451L|AFF2_uc011mxb.1_Missense_Mutation_p.S455L|AFF2_uc004fcs.2_Missense_Mutation_p.S457L|AFF2_uc011mxc.1_Missense_Mutation_p.S131L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	490					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGCGAATCGGAGAGCAGC	0.557													T	148035181	T	T	148035181	3	4	80	1	0	0	0	0	1	0	0	0	357	893	31	2	1562	2	AFF2	23	148035181	Missense_Mutation	SNP	C	TCGA-06-2563-01A-01D-1494-08	7039537	148035181	7235379	91	5469											
CELA3A	10136	broad.mit.edu	37	chr1	22333423	22333423	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcccagctgggagatgccGtccagctcgcctcactccct	11	18	1	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr1:22333423G>A	uc001bfl.2	+	5	434	c.415G>A	c.(415-417)GTC>ATC	p.V139I		NM_005747	NP_005738	P09093	CEL3A_HUMAN	elastase 3A, pancreatic preproprotein	139	Peptidase S1.				cholesterol metabolic process|digestion|proteolysis		serine-type endopeptidase activity			haematopoietic_and_lymphoid_tissue(1)	1						GGGAGATGCCGTCCAGCTCGC	0.627													A	22333423	A	A	22333423	3	1	81	1	0	0	0	0	1	0	0	0	3213	1145	40	1	433	1	CELA3A	1	22333423	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08		22333423	226917198	1	5470											
EPB41	2035	broad.mit.edu	37	chr1	29344851	29344851	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtctgaactgggagactacGacccagaactccatggcgtg	12	11	1	3			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr1:29344851G>A	uc001brm.1	+	6	1028	c.1021G>A	c.(1021-1023)GAC>AAC	p.D341N	EPB41_uc001brg.1_Missense_Mutation_p.D132N|EPB41_uc001brh.1_Missense_Mutation_p.D132N|EPB41_uc001bri.1_Missense_Mutation_p.D306N|EPB41_uc001brj.1_Missense_Mutation_p.D132N|EPB41_uc009vtk.1_Missense_Mutation_p.D306N|EPB41_uc001brk.2_Missense_Mutation_p.D341N|EPB41_uc001brl.1_Missense_Mutation_p.D341N|EPB41_uc009vtl.1_Missense_Mutation_p.D132N|EPB41_uc009vtm.1_5'UTR	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	341	FERM.				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		GGGAGACTACGACCCAGAACT	0.468													A	29344851	A	A	29344851	3	1	81	1	0	0	0	0	1	0	0	0	5151	1058	37	2	1043	2	EPB41	1	29344851	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	7011428	29344851	219905770	2	5471											
EIF2C3	192669	broad.mit.edu	37	chr1	36505436	36505436	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagcagatactgtgccacaGtaagagttcagagaccccga	10	11	1	3			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr1:36505436G>A	uc001bzp.2	+	15	2144	c.1888G>A	c.(1888-1890)GTA>ATA	p.V630I	EIF2C3_uc001bzq.2_Missense_Mutation_p.V396I	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	630	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTGTGCCACAGTAAGAGTTCA	0.383													A	36505436	A	A	36505436	3	1	81	1	0	0	0	0	1	0	0	0	5007	1029	36	3	1946	3	EIF2C3	1	36505436	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	7160585	36505436	212745185	3	5472											
EPHA10	284656	broad.mit.edu	37	chr1	38197175	38197175	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccggatctgaaagacgtagCgggtagccggcttcaggttg	15	10	2	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr1:38197175C>T	uc009vvi.2	-	7	1657	c.1571G>A	c.(1570-1572)CGC>CAC	p.R524H	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	524	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AAAGACGTAGCGGGTAGCCGG	0.592													T	38197175	T	T	38197175	3	4	81	1	0	0	0	0	1	0	0	0	5166	768	27	1	1499	1	EPHA10	1	38197175	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	1691739	38197175	211053446	4	5473											
GBP1	2633	broad.mit.edu	37	chr1	89525904	89525904	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctacatctcccagaccctcGgtgtccagcagaactaggat	8	14	2	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr1:89525904G>A	uc001dmx.2	-	3	514	c.294C>T	c.(292-294)ACC>ACT	p.T98T		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	98	GTP.				interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		CCAGACCCTCGGTGTCCAGCA	0.507													A	89525904	A	A	89525904	2	1	81	1	0	0	0	0	0	0	0	1	6273	1103	39	2		2	GBP1	1	89525904	Silent	SNP	G	TCGA-06-2564-01A-01D-1494-08	51328729	89525904	159724717	5	5474											
TXNIP	10628	broad.mit.edu	37	chr1	145440909	145440909	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttcttttctagctcctccCtgctatatggatgtcattcc	5	12	3	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr1:145440909C>T	uc001enn.3	+	7	1337	c.996C>T	c.(994-996)CCC>CCT	p.P332P	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Silent_p.P277P	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	332					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TAGCTCCTCCCTGCTATATGG	0.443													T	145440909	T	T	145440909	2	4	81	1	0	0	0	0	0	0	0	1	16800	668	24	3		3	TXNIP	1	145440909	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08	55915005	145440909	103809712	6	5475											
FLG	2312	broad.mit.edu	37	chr1	152278855	152278855	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacgtgttgttctgcttgcaCttctggatcctgactgccca	9	12	2	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr1:152278855C>T	uc001ezu.1	-	3	8543	c.8507G>A	c.(8506-8508)AGT>AAT	p.S2836N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2836	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGCTTGCACTTCTGGATCC	0.557									Ichthyosis				T	152278855	T	T	152278855	3	4	81	1	0	0	0	0	1	0	0	0	5922	565	20	3	3682	3	FLG	1	152278855	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	6837946	152278855	96971766	7	5476											
NT5C1B	93034	broad.mit.edu	37	chr2	18765378	18765378	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgaagcggaacgccgggccCggggtcaggatgacgttctc	16	12	2	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr2:18765378C>T	uc002rcz.2	-	6	1151	c.1047G>A	c.(1045-1047)CCG>CCA	p.P349P	NT5C1B_uc002rcy.2_Silent_p.P349P|NT5C1B_uc010exr.2_Silent_p.P291P|NT5C1B_uc010yju.1_Silent_p.P289P|NT5C1B_uc002rda.2_Silent_p.P289P|NT5C1B_uc010yjv.1_Silent_p.P366P|NT5C1B_uc010yjw.1_Silent_p.P332P|NT5C1B_uc010exs.2_Silent_p.P351P|NT5C1B_uc002rdb.1_Silent_p.P141P	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	349					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				ACGCCGGGCCCGGGGTCAGGA	0.587													T	18765378	T	T	18765378	2	4	81	1	0	0	0	0	0	0	0	1	10686	639	23	2		2	NT5C1B	2	18765378	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08		18765378	224433995	8	5477											
TBC1D8	11138	broad.mit.edu	37	chr2	101650173	101650173	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tttccccagggactcctccaCcagattcccgtagtaaccag	7	16	0	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr2:101650173C>G	uc010fiv.2	-	10	1737	c.1606G>C	c.(1606-1608)GTG>CTG	p.V536L	TBC1D8_uc010yvw.1_Missense_Mutation_p.V551L|TBC1D8_uc002tau.3_Missense_Mutation_p.V293L	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	536	Rab-GAP TBC.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						GACTCCTCCACCAGATTCCCG	0.542													G	101650173	G	G	101650173	3	3	81	1	0	0	0	0	1	0	0	0	15622	507	18	5	1860	5	TBC1D8	2	101650173	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	82884795	101650173	141549200	9	5478											
SAP130	79595	broad.mit.edu	37	chr2	128707447	128707447	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttctggggaaactaacctttGacccggacgtcactgtacct	9	12	2	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr2:128707447G>C	uc002tpp.2	-	17	2898	c.2766C>G	c.(2764-2766)GTC>GTG	p.V922V	SAP130_uc002tpn.2_Silent_p.V682V|SAP130_uc002tpo.2_Silent_p.V702V|SAP130_uc010fmd.2_Silent_p.V957V	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	922	Interactions with SIN3A and HDAC1.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		ACTAACCTTTGACCCGGACGT	0.433													C	128707447	C	C	128707447	2	2	81	1	0	0	0	0	0	0	0	1	13831	1277	45	5		5	SAP130	2	128707447	Silent	SNP	G	TCGA-06-2564-01A-01D-1494-08	27057274	128707447	114491926	10	5479											
KBTBD10	10324	broad.mit.edu	37	chr2	170382111	170382111	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaggtatgaagatgataaaAaagaatgggctgggatgttg	14	2	1	4			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr2:170382111A>G	uc002ueu.1	+	6	1803	c.1726A>G	c.(1726-1728)AAA>GAA	p.K576E	KBTBD10_uc010zdh.1_Missense_Mutation_p.K514E	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	576	Kelch 5.				striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						AGATGATAAAAAAGAATGGGC	0.373													G	170382111	G	G	170382111	3	3	81	1	0	0	0	0	1	0	0	0	7990	15	1	4	1748	4	KBTBD10	2	170382111	Missense_Mutation	SNP	A	TCGA-06-2564-01A-01D-1494-08	41674664	170382111	72817262	11	5480											
TTN	7273	broad.mit.edu	37	chr2	179419816	179419816	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgccagctctgagcttcacaGatgtacctgctctgtatttg	9	11	3	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr2:179419816G>A	uc010zfg.1	-	280	80890	c.80666C>T	c.(80665-80667)TCT>TTT	p.S26889F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S20584F|TTN_uc010zfi.1_Missense_Mutation_p.S20517F|TTN_uc010zfj.1_Missense_Mutation_p.S20392F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27816							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGCTTCACAGATGTACCTGC	0.373													A	179419816	A	A	179419816	3	1	81	1	0	0	0	0	1	0	0	0	16732	942	33	3	19737	3	TTN	2	179419816	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	9037705	179419816	63779557	12	5481											
PLCL1	5334	broad.mit.edu	37	chr2	198966043	198966043	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggtttctcatagaaatggCggacacagtccaggaaaaga	11	9	1	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr2:198966043C>T	uc010fsp.2	+	4	3245	c.2954C>T	c.(2953-2955)GCG>GTG	p.A985V	PLCL1_uc002uuv.3_Missense_Mutation_p.A906V	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	985					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	ATAGAAATGGCGGACACAGTC	0.318													T	198966043	T	T	198966043	3	4	81	1	0	0	0	0	1	0	0	0	12039	768	27	1	2968	1	PLCL1	2	198966043	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	19546227	198966043	44233330	13	5482											
COL4A4	1286	broad.mit.edu	37	chr2	227872085	227872085	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaccggctgattttctggcGttgggcctggctttctttta	12	10	2	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr2:227872085G>A	uc010zlt.1	-	47	5683	c.5029C>T	c.(5029-5031)CGC>TGC	p.R1677C		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1677	Collagen IV NC1.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ATTTTCTGGCGTTGGGCCTGG	0.493													A	227872085	A	A	227872085	3	1	81	1	0	0	0	0	1	0	0	0	3693	1145	40	1	47	1	COL4A4	2	227872085	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	28906042	227872085	15327288	14	5483											
ATP2B2	491	broad.mit.edu	37	chr3	10387792	10387792	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtcacggccaccacctgccGctgctcagtgtgtgtgctgt	12	15	2	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr3:10387792G>A	uc003bvt.2	-	17	2873	c.2434C>T	c.(2434-2436)CGG>TGG	p.R812W	ATP2B2_uc003bvv.2_Missense_Mutation_p.R767W|ATP2B2_uc003bvw.2_Missense_Mutation_p.R767W|ATP2B2_uc010hdo.2_Missense_Mutation_p.R517W	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	812	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						ACCACCTGCCGCTGCTCAGTG	0.682													A	10387792	A	A	10387792	3	1	81	1	0	0	0	0	1	0	0	0	1140	1086	38	1	1325	1	ATP2B2	3	10387792	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08		10387792	187634638	15	5484											
SLC6A20	54716	broad.mit.edu	37	chr3	45814090	45814090	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcacgcaatagggcagtgaCgccgtgaaatacaccacctg	11	12	0	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr3:45814090C>T	uc011bai.1	-	5	724	c.600G>A	c.(598-600)GCG>GCA	p.A200A	SLC6A20_uc003cow.2_5'Flank|SLC6A20_uc011baj.1_Intron	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	200	Helical; Name=5; (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		AGGGCAGTGACGCCGTGAAAT	0.597													T	45814090	T	T	45814090	2	4	81	1	0	0	0	0	0	0	0	1	14684	523	19	1		1	SLC6A20	3	45814090	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08	35426298	45814090	152208340	16	5485											
GHSR	2693	broad.mit.edu	37	chr3	172165997	172165997	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcgcagctcgcggaagcgCgacaccaccagcatggtgag	15	13	0	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr3:172165997C>T	uc003fib.1	-	1	207	c.207G>A	c.(205-207)TCG>TCA	p.S69S	GHSR_uc011bpv.1_Silent_p.S69S	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	69	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CGCGGAAGCGCGACACCACCA	0.657													T	172165997	T	T	172165997	2	4	81	1	0	0	0	0	0	0	0	1	6375	755	27	1		1	GHSR	3	172165997	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08	126351907	172165997	25856433	17	5486											
SULT1B1	27284	broad.mit.edu	37	chr4	70599914	70599914	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtaccaggaaaaggctgtaaAttattcattaagtcaaaatg	8	5	2	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr4:70599914A>G	uc003hen.2	-	5	742	c.444T>C	c.(442-444)AAT>AAC	p.N148N		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	148					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						AAGGCTGTAAATTATTCATTA	0.353													G	70599914	G	G	70599914	2	3	81	1	0	0	0	0	0	0	0	1	15373	98	4	4		4	SULT1B1	4	70599914	Silent	SNP	A	TCGA-06-2564-01A-01D-1494-08		70599914	120554362	18	5487											
SEPT11	55752	broad.mit.edu	37	chr4	77949846	77949846	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aactgcagaagaaagaagaaGaaatgagacaaatgtttgtt	10	3	0	6			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr4:77949846G>A	uc003hkj.2	+	8	1180	c.1018G>A	c.(1018-1020)GAA>AAA	p.E340K	SEPT11_uc010ijh.1_Missense_Mutation_p.E332K|SEPT11_uc011cca.1_Missense_Mutation_p.E350K	NM_018243	NP_060713	Q9NVA2	SEP11_HUMAN	septin 11	340	Potential.				cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding				0						GAAAGAAGAAGAAATGAGACA	0.403													A	77949846	A	A	77949846	3	1	81	1	0	0	0	0	1	0	0	0	14061	943	33	3	1048	3	SEPT11	4	77949846	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	7349932	77949846	113204430	19	5488											
FAT1	2195	broad.mit.edu	37	chr4	187541182	187541183	+	Frame_Shift_Ins	INS	-	A	A													ctgcaatctctgcactgtagINSaaaggtttttcaaacacagg							TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr4:187541182_187541183insA	uc003izf.2	-	10	6745_6746	c.6557_6558insT	c.(6556-6558)TTCfs	p.F2186fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2186	Extracellular (Potential).|Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CTGCACTGTAGAAAGGTTTTTC	0.51										HNSCC(5;0.00058)			A	187541183	A	A	187541182	7	5	81	1	0	1	1	0	0	0	0	0	5689	933	33	0	7280	0	FAT1	4	187541182	Frame_Shift_Ins	INS	-	TCGA-06-2564-01A-01D-1494-08	109591336	187541182	3613094	20	5489											
FSTL4	23105	broad.mit.edu	37	chr5	132652162	132652162	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatgcccacctgagccagttCggagctgctgaggtggccat	14	12	0	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr5:132652162C>T	uc003kyn.1	-	5	810	c.592G>A	c.(592-594)GAA>AAA	p.E198K		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	198	Potential.|EF-hand.					extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAGCCAGTTCGGAGCTGCTG	0.557													T	132652162	T	T	132652162	3	4	81	1	0	0	0	0	1	0	0	0	6079	893	31	2	1984	2	FSTL4	5	132652162	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08		132652162	48263098	21	5490											
NPM1	4869	broad.mit.edu	37	chr5	170819769	170819769	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggatgtgaaactcttAagtatatctggaaagcggtc	13	5	2	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr5:170819769A>C	uc011dex.1	+	6	543	c.408A>C	c.(406-408)TTA>TTC	p.L136F	NPM1_uc003mbh.2_Missense_Mutation_p.L136F|NPM1_uc003mbi.2_Missense_Mutation_p.L136F|NPM1_uc003mbj.2_Missense_Mutation_p.L136F	NM_002520	NP_002511	P06748	NPM_HUMAN	nucleophosmin 1 isoform 1	136	Required for interaction with SENP3.				anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	haematopoietic_and_lymphoid_tissue(3109)|skin(1)	3110	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGAAACTCTTAAGTATATCTG	0.388			T|F 	ALK|RARA|MLF1	NHL|APL|AML								C	170819769	C	C	170819769	3	2	81	1	0	0	0	0	1	0	0	0	10587	359	13	5	426	5	NPM1	5	170819769	Missense_Mutation	SNP	A	TCGA-06-2564-01A-01D-1494-08	38167607	170819769	10095491	22	5491											
NUP153	9972	broad.mit.edu	37	chr6	17629357	17629357	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagttaataacacctgtacCaaagctaaaacctgcagagg	9	9	0	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr6:17629357C>T	uc003ncd.1	-	18	3273	c.3073G>A	c.(3073-3075)GGT>AGT	p.G1025S	NUP153_uc011dje.1_Missense_Mutation_p.G1056S|NUP153_uc010jpl.1_Missense_Mutation_p.G983S	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	1025					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			ACACCTGTACCAAAGCTAAAA	0.443													T	17629357	T	T	17629357	3	4	81	1	0	0	0	0	1	0	0	0	10755	594	21	3	1374	3	NUP153	6	17629357	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08		17629357	153485710	23	5492											
SLC26A8	116369	broad.mit.edu	37	chr6	35923059	35923059	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctcctcccctggctttccGccacatcaggcagtcctggt	8	17	2	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr6:35923059G>A	uc003olm.2	-	17	2213	c.2102C>T	c.(2101-2103)GCG>GTG	p.A701V	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.A283V|SLC26A8_uc003oln.2_Missense_Mutation_p.A701V|SLC26A8_uc003oll.2_Missense_Mutation_p.A596V	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	701	Interaction with RACGAP1.|STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						CTGGCTTTCCGCCACATCAGG	0.502													A	35923059	A	A	35923059	3	1	81	1	0	0	0	0	1	0	0	0	14523	1087	38	1	826	1	SLC26A8	6	35923059	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	18293702	35923059	135192008	24	5493											
FRK	2444	broad.mit.edu	37	chr6	116263659	116263659	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaacgcagtgtctcaaatGtaggtcgttccttaggctct	9	11	2	0	rs142072444		TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr6:116263659G>A	uc003pwi.1	-	8	1883	c.1436C>T	c.(1435-1437)ACA>ATA	p.T479I		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	479	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TGTCTCAAATGTAGGTCGTTC	0.398													A	116263659	A	A	116263659	3	1	81	1	0	0	0	0	1	0	0	0	6048	1377	48	3	85	3	FRK	6	116263659	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	80340600	116263659	54851408	25	5494											
DFNA5	1687	broad.mit.edu	37	chr7	24742379	24742379	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacctgggaggttgcttacCaagtggcacagtgtgggaat	14	9	0	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr7:24742379C>T	uc010kus.1	-	9	1345	c.1257G>A	c.(1255-1257)TTG>TTA	p.L419L	DFNA5_uc003swz.2_Silent_p.L255L|DFNA5_uc003sxa.1_Silent_p.L419L|DFNA5_uc010kut.1_Silent_p.L255L	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	419					sensory perception of sound					ovary(1)	1						GGTTGCTTACCAAGTGGCACA	0.507													T	24742379	T	T	24742379	2	4	81	1	0	0	0	0	0	0	0	1	4454	608	21	3		3	DFNA5	7	24742379	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08		24742379	134396284	26	5495											
TNS3	64759	broad.mit.edu	37	chr7	47440469	47440469	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaactgcaggcggaaaatgaCgtcacgggtggccgagcggt	16	9	1	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr7:47440469C>T	uc003tnv.2	-	14	1133	c.766G>A	c.(766-768)GTC>ATC	p.V256I	TNS3_uc003tnw.2_Missense_Mutation_p.V256I|TNS3_uc010kyo.1_3'UTR	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	256	C2 tensin-type.					focal adhesion	protein binding			ovary(4)	4						CGGAAAATGACGTCACGGGTG	0.567													T	47440469	T	T	47440469	3	4	81	1	0	0	0	0	1	0	0	0	16341	536	19	1	3643	1	TNS3	7	47440469	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	22698090	47440469	111698194	27	5496											
TFPI2	7980	broad.mit.edu	37	chr7	93516148	93516148	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtttaaaattgcttcttcCgaattttccggattctactg	6	8	2	0	rs12669450		TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr7:93516148C>T	uc003umy.1	-	5	767	c.692G>A	c.(691-693)CGG>CAG	p.R231Q	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_3'UTR|TFPI2_uc003una.1_Missense_Mutation_p.R220Q|TFPI2_uc003unb.1_Missense_Mutation_p.R237Q|TFPI2_uc010lfg.1_Missense_Mutation_p.R107Q	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	231					blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			TTGCTTCTTCCGAATTTTCCG	0.328													T	93516148	T	T	93516148	3	4	81	1	0	0	0	0	1	0	0	0	15806	652	23	2	19	2	TFPI2	7	93516148	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	46075679	93516148	65622515	28	5497											
NRF1	4899	broad.mit.edu	37	chr7	129357140	129357140	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaggccacccaggcggtgGcatcgttggcagaggccgca	16	13	0	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr7:129357140G>A	uc003voz.2	+	9	1264	c.1147G>A	c.(1147-1149)GCA>ACA	p.A383T	NRF1_uc003vpa.2_Missense_Mutation_p.A383T|NRF1_uc011kpa.1_Missense_Mutation_p.A222T|NRF1_uc003vpb.2_Missense_Mutation_p.A383T	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	383	Required for transcriptional activation.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						CCAGGCGGTGGCATCGTTGGC	0.567													A	129357140	A	A	129357140	3	1	81	1	0	0	0	0	1	0	0	0	10646	1203	42	3	1177	3	NRF1	7	129357140	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	35840992	129357140	29781523	29	5498											
ZC3HC1	51530	broad.mit.edu	37	chr7	129662254	129662254	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctctgctggggcgctggcatCtggttcagttccaccattct	11	13	4	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr7:129662254C>T	uc003vpi.2	-	9	1372	c.1345G>A	c.(1345-1347)GAT>AAT	p.D449N	ZC3HC1_uc003vph.2_Missense_Mutation_p.D293N|ZC3HC1_uc010lma.2_Missense_Mutation_p.D265N	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	449					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					GCGCTGGCATCTGGTTCAGTT	0.552													T	129662254	T	T	129662254	3	4	81	1	0	0	0	0	1	0	0	0	17574	913	32	3	171	3	ZC3HC1	7	129662254	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	305114	129662254	29476409	30	5499											
ABCF2	10061	broad.mit.edu	37	chr7	150921937	150921937	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggtgtcactgagcagctcttGaccatgaaaggtaagtgaga	13	7	2	4			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr7:150921937G>A	uc003wjp.2	-	3	403	c.292C>T	c.(292-294)CAA>TAA	p.Q98*	ABCF2_uc003wjo.1_Nonsense_Mutation_p.Q98*	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	98	ABC transporter 1.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCAGCTCTTGACCATGAAAG	0.507													A	150921937	A	A	150921937	4	1	81	1	0	0	0	0	0	1	0	0	66	1299	45	3	1672	3	ABCF2	7	150921937	Nonsense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	21259683	150921937	8216726	31	5500											
RAB11FIP1	80223	broad.mit.edu	37	chr8	37732412	37732412	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttgtggcctctgagtttgCgggggccatgttttccctga	13	9	1	2	rs140686896		TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr8:37732412C>T	uc003xkm.1	-	3	1287	c.1243G>A	c.(1243-1245)GCA>ACA	p.A415T	RAB11FIP1_uc010lvz.1_Missense_Mutation_p.A263T|RAB11FIP1_uc003xkn.1_Missense_Mutation_p.A415T|RAB11FIP1_uc003xkl.1_5'Flank|RAB11FIP1_uc003xko.1_5'Flank|RAB11FIP1_uc003xkp.1_Missense_Mutation_p.A263T	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	415					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TCTGAGTTTGCGGGGGCCATG	0.557													T	37732412	T	T	37732412	3	4	81	1	0	0	0	0	1	0	0	0	12893	768	27	1	2624	1	RAB11FIP1	8	37732412	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08		37732412	108631610	32	5501											
IMPAD1	54928	broad.mit.edu	37	chr8	57878872	57878872	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttctcattgtaggaagagCgggctttcacatttgaacca	9	9	3	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr8:57878872C>T	uc003xte.3	-	4	969	c.686G>A	c.(685-687)CGC>CAC	p.R229H		NM_017813	NP_060283	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	229						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			ovary(1)	1		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				GTAGGAAGAGCGGGCTTTCAC	0.423													T	57878872	T	T	57878872	3	4	81	1	0	0	0	0	1	0	0	0	7725	768	27	1	401	1	IMPAD1	8	57878872	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	20146460	57878872	88485150	33	5502											
MTDH	92140	broad.mit.edu	37	chr8	98735243	98735243	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caagtcaaataccaagcaaaAtagtgtgcctccttcacaga	6	11	2	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr8:98735243A>G	uc003yhz.2	+	11	1986	c.1658A>G	c.(1657-1659)AAT>AGT	p.N553S	MTDH_uc010mbf.2_RNA	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	553	Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			ACCAAGCAAAATAGTGTGCCT	0.363													G	98735243	G	G	98735243	3	3	81	1	0	0	0	0	1	0	0	0	9917	101	4	4	1700	4	MTDH	8	98735243	Missense_Mutation	SNP	A	TCGA-06-2564-01A-01D-1494-08	40856371	98735243	47628779	34	5503											
VPS13B	157680	broad.mit.edu	37	chr8	100732741	100732741	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aaagtgaacaaagttcagatGacctacggacaggtctattt	9	7	2	3			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr8:100732741G>A	uc003yiv.2	+	38	7012	c.6901G>A	c.(6901-6903)GAC>AAC	p.D2301N	VPS13B_uc003yiw.2_Missense_Mutation_p.D2276N	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2301					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAGTTCAGATGACCTACGGAC	0.403													A	100732741	A	A	100732741	3	1	81	1	0	0	0	0	1	0	0	0	17187	1290	45	3	7241	3	VPS13B	8	100732741	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	1997498	100732741	45631281	35	5504											
FBP2	8789	broad.mit.edu	37	chr9	97333780	97333780	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtccacgccttgccctgtGgagagagccaccagggttgc	14	13	0	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr9:97333780G>A	uc004auv.2	-	4	598	c.531C>T	c.(529-531)TCC>TCT	p.S177S	uc004auu.2_Intron	NM_003837	NP_003828	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	177					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)				CTTGCCCTGTGGAGAGAGCCA	0.567													A	97333780	A	A	97333780	2	1	81	1	0	0	0	0	0	0	0	1	5706	1335	47	3		3	FBP2	9	97333780	Silent	SNP	G	TCGA-06-2564-01A-01D-1494-08		97333780	43879651	36	5505											
C9orf102	375748	broad.mit.edu	37	chr9	98669532	98669532	+	Nonsense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aacttatgaaacactacgctTatgcctggatgaacttaaca	6	9	0	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr9:98669532T>G	uc004avt.3	+	4	1188	c.800T>G	c.(799-801)TTA>TGA	p.L267*	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Intron|C9orf102_uc010mry.1_Intron|C9orf102_uc010mrz.2_Nonsense_Mutation_p.L78*	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	267	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				ACACTACGCTTATGCCTGGAT	0.303													G	98669532	G	G	98669532	4	3	81	1	0	0	0	0	0	1	0	0	2445	1764	61	5	814	5	C9orf102	9	98669532	Nonsense_Mutation	SNP	T	TCGA-06-2564-01A-01D-1494-08	1335752	98669532	42543899	37	5506											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112900147	112900147	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gagaaggcgtctccaagtcaTttagtgatcatggtttctat	10	7	4	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr9:112900147T>A	uc004bei.2	+	9	3211	c.3019T>A	c.(3019-3021)TTT>ATT	p.F1007I	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.F775I|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.F775I|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.F585I|AKAP2_uc011lwi.1_Missense_Mutation_p.F633I|AKAP2_uc004bem.2_Missense_Mutation_p.F633I|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.F593I|AKAP2_uc011lwj.1_Missense_Mutation_p.F544I|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.F544I	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	544							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CTCCAAGTCATTTAGTGATCA	0.542													A	112900147	A	A	112900147	3	1	81	1	0	0	0	0	1	0	0	0	11410	1493	52	5	2353	5	PALM2-AKAP2	9	112900147	Missense_Mutation	SNP	T	TCGA-06-2564-01A-01D-1494-08	14230615	112900147	28313284	38	5507											
SVEP1	79987	broad.mit.edu	37	chr9	113189912	113189912	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acggtgttcctgaaagtgaaGttattccccgtaatgacagc	10	9	0	3			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr9:113189912G>T	uc010mtz.2	-	36	6271	c.5934C>A	c.(5932-5934)AAC>AAA	p.N1978K	SVEP1_uc010mty.2_5'UTR	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1978	Sushi 10.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TGAAAGTGAAGTTATTCCCCG	0.527											OREG0019389	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	113189912	T	T	113189912	3	4	81	1	0	0	0	0	1	0	0	0	15417	1020	36	5	4833	5	SVEP1	9	113189912	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	289765	113189912	28023519	39	5508											
ZNF883	169834	broad.mit.edu	37	chr9	115759611	115759611	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgtatgcgtcctctgatgtCgaattagtgatgttctatag	10	7	2	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr9:115759611C>T	uc011lwy.1	-	5	2168	c.929G>A	c.(928-930)CGA>CAA	p.R310Q		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	310	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCTCTGATGTCGAATTAGTGA	0.373													T	115759611	T	T	115759611	3	4	81	1	0	0	0	0	1	0	0	0	18195	884	31	2	212	2	ZNF883	9	115759611	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	2569699	115759611	25453820	40	5509											
NR5A1	2516	broad.mit.edu	37	chr9	127262849	127262849	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccggtgcgggagggggcggCgggggcacccccatcggggg	23	12	0	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr9:127262849C>T	uc004boo.1	-	4	577	c.390G>A	c.(388-390)CCG>CCA	p.P130P		NM_004959	NP_004950	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	130					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						GAGGGGGCGGCGGGGGCACCC	0.697													T	127262849	T	T	127262849	2	4	81	1	0	0	0	0	0	0	0	1	10635	755	27	1		1	NR5A1	9	127262849	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08	11503238	127262849	13950582	41	5510											
PRRG4	79056	broad.mit.edu	37	chr11	32875008	32875008	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagtgtttcaccaccaccaCcatatcctgggcacacaaaa	5	15	1	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr11:32875008C>T	uc001mtx.2	+	6	869	c.616C>T	c.(616-618)CCA>TCA	p.P206S		NM_024081	NP_076986	Q9BZD6	TMG4_HUMAN	proline rich Gla (G-carboxyglutamic acid) 4	206	Cytoplasmic (Potential).|Poly-Pro.					extracellular region|Golgi apparatus|integral to membrane	calcium ion binding				0	Breast(20;0.206)					ACCACCACCACCATATCCTGG	0.438													T	32875008	T	T	32875008	3	4	81	1	0	0	0	0	1	0	0	0	12608	507	18	3	634	3	PRRG4	11	32875008	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08		32875008	102131508	42	5511											
TRIM49	57093	broad.mit.edu	37	chr11	89531694	89531694	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aaacttctaggtgttgcagtGaaatagggtacatcttgatg	11	5	2	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr11:89531694G>A	uc001pdb.2	-	8	1292	c.963C>T	c.(961-963)TTC>TTT	p.F321F		NM_020358	NP_065091	P0CI25	TRI49_HUMAN	ring finger protein 18	321	B30.2/SPRY.					intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GTGTTGCAGTGAAATAGGGTA	0.418													A	89531694	A	A	89531694	2	1	81	1	0	0	0	0	0	0	0	1	16521	1281	45	3		3	TRIM49	11	89531694	Silent	SNP	G	TCGA-06-2564-01A-01D-1494-08	56656686	89531694	45474822	43	5512											
ENO2	2026	broad.mit.edu	37	chr12	7026819	7026819	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggcagctgagcgggaactgCccctgtatcgccacattgct	13	13	0	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr12:7026819C>G	uc001qru.1	+	6	607	c.385C>G	c.(385-387)CCC>GCC	p.P129A	ENO2_uc009zfi.1_Missense_Mutation_p.P129A|ENO2_uc010sfq.1_Missense_Mutation_p.P86A|ENO2_uc001qrv.1_Missense_Mutation_p.P129A	NM_001975	NP_001966	P09104	ENOG_HUMAN	enolase 2	129					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity				0						GCGGGAACTGCCCCTGTATCG	0.617													G	7026819	G	G	7026819	3	3	81	1	0	0	0	0	1	0	0	0	5122	739	26	5	403	5	ENO2	12	7026819	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08		7026819	126825076	44	5513											
MLL2	8085	broad.mit.edu	37	chr12	49448322	49448322	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcactcacctccaggttctCctaggtgggcaggtgtaagg	12	12	3	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr12:49448322C>T	uc001rta.3	-	3	389	c.389G>A	c.(388-390)GGA>GAA	p.G130E		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	130					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCCAGGTTCTCCTAGGTGGGC	0.557			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			T	49448322	T	T	49448322	3	4	81	1	0	0	0	0	1	0	0	0	9621	855	30	3	16432	3	MLL2	12	49448322	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	42421503	49448322	84403573	45	5514											
LRRIQ1	84125	broad.mit.edu	37	chr12	85492269	85492269	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcttactgatgtagagggCgttgaaaattgtggattgct	12	5	1	3			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr12:85492269C>T	uc001tac.2	+	12	3135	c.3024C>T	c.(3022-3024)GGC>GGT	p.G1008G	LRRIQ1_uc001tab.1_Silent_p.G1008G	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1008	LRR 6.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ATGTAGAGGGCGTTGAAAATT	0.343													T	85492269	T	T	85492269	2	4	81	1	0	0	0	0	0	0	0	1	9029	755	27	1		1	LRRIQ1	12	85492269	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08	36043947	85492269	48359626	46	5515											
LRRIQ1	84125	broad.mit.edu	37	chr12	85546073	85546073	+	Frame_Shift_Del	DEL	G	-	-													tgcaggctgccttagaagaaGaatggctagcattagattcc							TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr12:85546073delG	uc001tac.2	+	20	4456	c.4345delG	c.(4345-4347)GAAfs	p.E1449fs		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1449										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CTTAGAAGAAGAATGGCTAGC	0.353													-	85546073	-	-	85546073	7	5	81	1	0	1	0	1	0	0	0	0	9029	943	33	0	4423	0	LRRIQ1	12	85546073	Frame_Shift_Del	DEL	G	TCGA-06-2564-01A-01D-1494-08	53804	85546073	48305822	47	5516											
GPR81	27198	broad.mit.edu	37	chr12	123214178	123214178	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaatagagtctagcagacaCgctgggcaggtagcatgtga	14	7	1	3			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr12:123214178C>T	uc001ucz.2	-	1	952	c.709G>A	c.(709-711)GTG>ATG	p.V237M	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	237	Helical; Name=6; (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		CTAGCAGACACGCTGGGCAGG	0.582													T	123214178	T	T	123214178	3	4	81	1	0	0	0	0	1	0	0	0	6711	536	19	1	335	1	GPR81	12	123214178	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	37668105	123214178	10637717	48	5517											
ZNF10	7556	broad.mit.edu	37	chr12	133732279	133732279	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagagagacatttgaggcaAgtggcattcacccaaaagaa	10	9	1	4			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr12:133732279A>G	uc009zzb.2	+	5	894	c.447A>G	c.(445-447)CAA>CAG	p.Q149Q	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Silent_p.Q149Q	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	149				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		ATTTGAGGCAAGTGGCATTCA	0.428													G	133732279	G	G	133732279	2	3	81	1	0	0	0	0	0	0	0	1	17709	69	3	4		4	ZNF10	12	133732279	Silent	SNP	A	TCGA-06-2564-01A-01D-1494-08	10518101	133732279	119616	49	5518			1	20		3	3	182	N	T_A	1.087566e-07
ZNF10	7556	broad.mit.edu	37	chr12	133732444	133732444	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gatttagttcttaatggtcaTcaggacagttgtgcaagtaa	10	5	3	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr12:133732444T>A	uc009zzb.2	+	5	1059	c.612T>A	c.(610-612)CAT>CAA	p.H204Q	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.H204Q	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	204				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TTAATGGTCATCAGGACAGTT	0.363													A	133732444	A	A	133732444	3	1	81	1	0	0	0	0	1	0	0	0	17709	1432	50	5	626	5	ZNF10	12	133732444	Missense_Mutation	SNP	T	TCGA-06-2564-01A-01D-1494-08	165	133732444	119451	50	5519			1	20		3	3	182	N	T_A	1.087566e-07
ZNF10	7556	broad.mit.edu	37	chr12	133732460	133732460	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcatcaggacagttgtgcaAgtaacagtaatgaatgtggt	12	5	2	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr12:133732460A>G	uc009zzb.2	+	5	1075	c.628A>G	c.(628-630)AGT>GGT	p.S210G	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.S210G	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	210	C2H2-type 1; atypical.			Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CAGTTGTGCAAGTAACAGTAA	0.358													G	133732460	G	G	133732460	3	3	81	1	0	0	0	0	1	0	0	0	17709	72	3	4	642	4	ZNF10	12	133732460	Missense_Mutation	SNP	A	TCGA-06-2564-01A-01D-1494-08	16	133732460	119435	51	5520			1	20		3	3	182	N	T_A	1.087566e-07
POTEG	404785	broad.mit.edu	37	chr14	19553826	19553826	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gccgaggtaccacgtccgtcGagaagatctggacaagctcc	12	13	1	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr14:19553826G>A	uc001vuz.1	+	1	462	c.410G>A	c.(409-411)CGA>CAA	p.R137Q	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	137										ovary(1)	1						CACGTCCGTCGAGAAGATCTG	0.577													A	19553826	A	A	19553826	3	1	81	1	0	0	0	0	1	0	0	0	12266	1058	37	2	412	2	POTEG	14	19553826	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08		19553826	87795714	52	5521											
POTEG	404785	broad.mit.edu	37	chr14	19566060	19566060	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gaaaaacagatgctaaaagtCtcttctgaaaacagcaatcc	6	9	2	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr14:19566060C>G	uc001vuz.1	+	6	1156	c.1104C>G	c.(1102-1104)GTC>GTG	p.V368V	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA|uc001vvb.2_Intron	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	368										ovary(1)	1						TGCTAAAAGTCTCTTCTGAAA	0.214													G	19566060	G	G	19566060	2	3	81	1	0	0	0	0	0	0	0	1	12266	900	32	5		5	POTEG	14	19566060	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08	12234	19566060	87783480	53	5522											
ADCY4	196883	broad.mit.edu	37	chr14	24801072	24801072	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggaacgtggcccgcagggcGcgctccatcagcgccttgtg	15	15	1	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr14:24801072G>A	uc001wov.2	-	4	597	c.591C>T	c.(589-591)CGC>CGT	p.R197R	ADCY4_uc001wow.2_Silent_p.R197R|ADCY4_uc010toh.1_5'UTR|ADCY4_uc001wox.2_Silent_p.R197R|ADCY4_uc001woy.2_Silent_p.R197R	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	197	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		CCCGCAGGGCGCGCTCCATCA	0.667													A	24801072	A	A	24801072	2	1	81	1	0	0	0	0	0	0	0	1	296	1074	38	1		1	ADCY4	14	24801072	Silent	SNP	G	TCGA-06-2564-01A-01D-1494-08	5235012	24801072	82548468	54	5523											
SYT16	83851	broad.mit.edu	37	chr14	62547865	62547865	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcctgtgctgtccgcttccGcctgtacgctgcccggaaga	12	15	0	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr14:62547865G>A	uc001xfu.1	+	4	1504	c.1307G>A	c.(1306-1308)CGC>CAC	p.R436H	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	436	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GTCCGCTTCCGCCTGTACGCT	0.562													A	62547865	A	A	62547865	3	1	81	1	0	0	0	0	1	0	0	0	15469	1087	38	1	1321	1	SYT16	14	62547865	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	37746793	62547865	44801675	55	5524											
C15orf48	84419	broad.mit.edu	37	chr15	45723253	45723253	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggtggagcctcatctttcGctgtgtattctctttggaaa	11	9	3	0	rs143173357		TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr15:45723253G>A	uc001zvg.2	+	3	209	c.91G>A	c.(91-93)GCT>ACT	p.A31T	C15orf48_uc001zvh.2_Missense_Mutation_p.A31T|MIR147B_hsa-mir-147b|MI0005544_5'Flank	NM_197955	NP_922946	Q9C002	NMES1_HUMAN	normal mucosa of esophagus specific 1	31						nucleus		p.A31P(1)		ovary(1)	1		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.67e-16)|GBM - Glioblastoma multiforme(94;1.71e-06)		CTCATCTTTCGCTGTGTATTC	0.413													A	45723253	A	A	45723253	3	1	81	1	0	0	0	0	1	0	0	0	1799	1087	38	1	97	1	C15orf48	15	45723253	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08		45723253	56808139	56	5525											
CCDC33	80125	broad.mit.edu	37	chr15	74564064	74564064	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctttctccggggagtcaaCgagcccctggccaacaaccc	9	16	3	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr15:74564064C>T	uc002axo.2	+	6	961	c.567C>T	c.(565-567)AAC>AAT	p.N189N	CCDC33_uc002axp.2_Silent_p.N11N	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	392							protein binding			ovary(3)|skin(2)	5						GGGGAGTCAACGAGCCCCTGG	0.592													T	74564064	T	T	74564064	2	4	81	1	0	0	0	0	0	0	0	1	2806	535	19	1		1	CCDC33	15	74564064	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08	28840811	74564064	27967328	57	5526											
CCDC33	80125	broad.mit.edu	37	chr15	74573074	74573074	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgttgccgctaaagagcCgtttgtaccagaagatgctg	12	9	0	3			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr15:74573074C>T	uc002axo.2	+	9	1349	c.955C>T	c.(955-957)CGT>TGT	p.R319C	CCDC33_uc002axp.2_Missense_Mutation_p.R141C	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	522							protein binding			ovary(3)|skin(2)	5						GCTAAAGAGCCGTTTGTACCA	0.612													T	74573074	T	T	74573074	3	4	81	1	0	0	0	0	1	0	0	0	2806	652	23	2	989	2	CCDC33	15	74573074	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	9010	74573074	27958318	58	5527											
ITGAX	3687	broad.mit.edu	37	chr16	31374348	31374348	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcggggccccccattactaCgagcagacccgagggggcca	13	15	0	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr16:31374348C>T	uc002ebu.1	+	13	1519	c.1452C>T	c.(1450-1452)TAC>TAT	p.Y484Y	ITGAX_uc002ebt.2_Silent_p.Y484Y|ITGAX_uc010vfk.1_Silent_p.Y134Y	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	484	FG-GAP 5.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCCATTACTACGAGCAGACCC	0.677													T	31374348	T	T	31374348	2	4	81	1	0	0	0	0	0	0	0	1	7889	547	19	1		1	ITGAX	16	31374348	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08		31374348	58980405	59	5528											
MYLK3	91807	broad.mit.edu	37	chr16	46755087	46755087	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgatgtcctgtctgattgaCgcacaatatgttctccggct	9	10	2	3			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr16:46755087C>T	uc002eei.3	-	9	2049	c.1933G>A	c.(1933-1935)GTC>ATC	p.V645I	MYLK3_uc010vge.1_Missense_Mutation_p.V304I	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	645	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GTCTGATTGACGCACAATATG	0.448													T	46755087	T	T	46755087	3	4	81	1	0	0	0	0	1	0	0	0	10058	536	19	1	546	1	MYLK3	16	46755087	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	15380739	46755087	43599666	60	5529											
SLC2A4	6517	broad.mit.edu	37	chr17	7187697	7187697	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctcgaggggcctgccagaaaGagtaagctctcccgctgcag	13	13	1	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr17:7187697G>A	uc002gfp.2	+	6	926	c.726G>A	c.(724-726)AAG>AAA	p.K242K	SLC2A4_uc002gfo.2_Silent_p.K242K|SLC2A4_uc010cmd.2_RNA	NM_001042	NP_001033	P14672	GTR4_HUMAN	glucose transporter 4	242	Cytoplasmic (Potential).				carbohydrate metabolic process|glucose homeostasis|glucose import	external side of plasma membrane|integral to plasma membrane|perinuclear region of cytoplasm	D-glucose transmembrane transporter activity|protein binding				0						CTGCCAGAAAGAGTAAGCTCT	0.632													A	7187697	A	A	7187697	2	1	81	1	0	0	0	0	0	0	0	1	14546	956	33	3		3	SLC2A4	17	7187697	Silent	SNP	G	TCGA-06-2564-01A-01D-1494-08		7187697	74007513	61	5530											
MYOCD	93649	broad.mit.edu	37	chr17	12666835	12666835	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtggctggacctcactccGccaaattccacaccaggctt	9	15	1	0	rs149918258		TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr17:12666835G>A	uc002gnn.2	+	13	2990	c.2691G>A	c.(2689-2691)CCG>CCA	p.P897P	MYOCD_uc002gno.2_Silent_p.P945P|MYOCD_uc002gnq.2_Silent_p.P621P	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	897					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ACCTCACTCCGCCAAATTCCA	0.512													A	12666835	A	A	12666835	2	1	81	1	0	0	0	0	0	0	0	1	10087	1074	38	1		1	MYOCD	17	12666835	Silent	SNP	G	TCGA-06-2564-01A-01D-1494-08	5479138	12666835	68528375	62	5531											
KCNJ12	3768	broad.mit.edu	37	chr17	21319341	21319341	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgtggaggcccatgtgcgCgcgcagctcatcaagccgcg	14	13	2	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr17:21319341C>T	uc002gyv.1	+	3	1392	c.687C>T	c.(685-687)CGC>CGT	p.R229R		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	229	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCCATGTGCGCGCGCAGCTCA	0.642										Prostate(3;0.18)			T	21319341	T	T	21319341	2	4	81	1	0	0	0	0	0	0	0	1	8046	755	27	1		1	KCNJ12	17	21319341	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08	8652506	21319341	59875869	63	5532											
RHBDF2	79651	broad.mit.edu	37	chr17	74473065	74473065	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttggaggcgatgcgcttgCcgcgccggggcccggggact	18	14	0	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr17:74473065C>T	uc002jrq.1	-	9	1342	c.1049G>A	c.(1048-1050)GGC>GAC	p.G350D	RHBDF2_uc002jrp.1_Missense_Mutation_p.G321D|RHBDF2_uc002jrr.1_Missense_Mutation_p.G202D|RHBDF2_uc010wtf.1_Missense_Mutation_p.G321D|RHBDF2_uc002jrs.1_Missense_Mutation_p.G345D	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	350	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						GATGCGCTTGCCGCGCCGGGG	0.647													T	74473065	T	T	74473065	3	4	81	1	0	0	0	0	1	0	0	0	13320	739	26	3	1565	3	RHBDF2	17	74473065	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	53153724	74473065	6722145	64	5533											
POLI	11201	broad.mit.edu	37	chr18	51809324	51809324	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaatttcagttgctcagcGtatccaaaagctcagttttg	9	8	3	0	rs146107490		TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr18:51809324G>A	uc002lfj.3	+	6	982	c.914G>A	c.(913-915)CGT>CAT	p.R305H	POLI_uc010xds.1_Missense_Mutation_p.R226H|POLI_uc002lfk.3_Missense_Mutation_p.R202H|POLI_uc002lfl.1_Missense_Mutation_p.R237H|POLI_uc010dpg.2_5'UTR	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	305					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		GTTGCTCAGCGTATCCAAAAG	0.393								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					A	51809324	A	A	51809324	3	1	81	1	0	0	0	0	1	0	0	0	12203	1145	40	1	936	1	POLI	18	51809324	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08		51809324	26267924	65	5534											
ZNF77	58492	broad.mit.edu	37	chr19	2933838	2933838	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagggcttctctccagtatgCgtcctcacgtggattcgaag	11	11	2	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr19:2933838C>T	uc002lws.3	-	4	1418	c.1287G>A	c.(1285-1287)ACG>ACA	p.T429T		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	429	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCAGTATGCGTCCTCACGT	0.512													T	2933838	T	T	2933838	2	4	81	1	0	0	0	0	0	0	0	1	18139	755	27	1		1	ZNF77	19	2933838	Silent	SNP	C	TCGA-06-2564-01A-01D-1494-08		2933838	56195145	66	5535											
TJP3	27134	broad.mit.edu	37	chr19	3735631	3735631	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcggaaccagatgagcaaCggtcaggtgggtggtgactc	15	9	2	3			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr19:3735631C>T	uc010xhv.1	+	8	1153	c.1153C>T	c.(1153-1155)CGG>TGG	p.R385W	TJP3_uc010xhs.1_Missense_Mutation_p.R352W|TJP3_uc010xht.1_Missense_Mutation_p.R316W|TJP3_uc010xhu.1_Missense_Mutation_p.R361W|TJP3_uc010xhw.1_Missense_Mutation_p.R371W	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	366						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AGATGAGCAACGGTCAGGTGG	0.602													T	3735631	T	T	3735631	3	4	81	1	0	0	0	0	1	0	0	0	15928	527	19	1	1183	1	TJP3	19	3735631	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	801793	3735631	55393352	67	5536											
SH2D3A	10045	broad.mit.edu	37	chr19	6760704	6760704	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgtcctcgctaaagctgcGtcgcagaggcccctgccaag	13	14	0	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr19:6760704G>A	uc002mft.2	-	3	558	c.364C>T	c.(364-366)CGC>TGC	p.R122C	SH2D3A_uc010xjg.1_Intron	NM_005490	NP_005481	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	122					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2						CTAAAGCTGCGTCGCAGAGGC	0.612													A	6760704	A	A	6760704	3	1	81	1	0	0	0	0	1	0	0	0	14233	1145	40	1	1398	1	SH2D3A	19	6760704	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	3025073	6760704	52368279	68	5537											
FBN3	84467	broad.mit.edu	37	chr19	8154483	8154483	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaaagggacactcacagcGgaaggatccatcggtgttga	13	10	1	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr19:8154483G>A	uc002mjf.2	-	50	6343	c.6322C>T	c.(6322-6324)CGC>TGC	p.R2108C	FBN3_uc002mje.2_5'UTR	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2108	EGF-like 33; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CACTCACAGCGGAAGGATCCA	0.607													A	8154483	A	A	8154483	3	1	81	1	0	0	0	0	1	0	0	0	5704	1116	39	2	2163	2	FBN3	19	8154483	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	1393779	8154483	50974500	69	5538											
DDX49	54555	broad.mit.edu	37	chr19	19030579	19030579	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cttcgcggagctcgggctgtCatcgtggctcgtggaacaat	14	11	1	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr19:19030579C>T	uc002nkq.1	+	1	86	c.29C>T	c.(28-30)TCA>TTA	p.S10L	COPE_uc002nkk.2_5'Flank|COPE_uc002nkl.2_5'Flank|COPE_uc002nkm.2_5'Flank|COPE_uc002nkn.2_5'Flank|HOMER3_uc002nko.1_Intron|HOMER3_uc002nkp.1_Intron|DDX49_uc002nkr.1_RNA|DDX49_uc002nks.1_5'UTR|DDX49_uc002nkt.1_5'Flank	NM_019070	NP_061943	Q9Y6V7	DDX49_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	10	Q motif.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			Epithelial(12;0.0289)			CTCGGGCTGTCATCGTGGCTC	0.677													T	19030579	T	T	19030579	3	4	81	1	0	0	0	0	1	0	0	0	4366	838	29	3	31	3	DDX49	19	19030579	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	10876096	19030579	40098404	70	5539											
TSHZ3	57616	broad.mit.edu	37	chr19	31767726	31767726	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgactctaggtgactgatGtacgtggaaggagtcctgat	14	6	1	4			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr19:31767726G>A	uc002nsy.3	-	2	3038	c.2973C>T	c.(2971-2973)TAC>TAT	p.Y991Y		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	991	C2H2-type 4.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GGTGACTGATGTACGTGGAAG	0.488													A	31767726	A	A	31767726	2	1	81	1	0	0	0	0	0	0	0	1	16622	1372	48	3		3	TSHZ3	19	31767726	Silent	SNP	G	TCGA-06-2564-01A-01D-1494-08	12737147	31767726	27361257	71	5540											
VASP	7408	broad.mit.edu	37	chr19	46027874	46027874	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttccgagacccaaccctgcAcgcccagctccagtgattac	7	18	0	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr19:46027874A>G	uc002pcg.2	+	11	1345	c.1003A>G	c.(1003-1005)ACG>GCG	p.T335A	VASP_uc010eki.2_Missense_Mutation_p.T169A|VASP_uc002pci.2_Missense_Mutation_p.T321A	NM_003370	NP_003361	P50552	VASP_HUMAN	vasodilator-stimulated phosphoprotein	335	EVH2.				axon guidance|cell junction assembly|T cell receptor signaling pathway	actin cytoskeleton|cytosol|filopodium membrane|focal adhesion|lamellipodium membrane	actin binding|profilin binding|SH3 domain binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0145)|GBM - Glioblastoma multiforme(486;0.154)		CCAACCCTGCACGCCCAGCTC	0.498													G	46027874	G	G	46027874	3	3	81	1	0	0	0	0	1	0	0	0	17125	159	6	4	1045	4	VASP	19	46027874	Missense_Mutation	SNP	A	TCGA-06-2564-01A-01D-1494-08	14260148	46027874	13101109	72	5541											
CSE1L	1434	broad.mit.edu	37	chr20	47688965	47688965	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggaatttactagttacaaCgggtcaagaggttaaatatg	10	5	1	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr20:47688965C>T	uc002xty.2	+	9	1045	c.911C>T	c.(910-912)ACG>ATG	p.T304M	CSE1L_uc010zyg.1_Missense_Mutation_p.T87M|CSE1L_uc010ghx.2_Intron|CSE1L_uc010ghy.2_Translation_Start_Site|CSE1L_uc010zyh.1_5'Flank	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	304					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			CTAGTTACAACGGGTCAAGAG	0.383													T	47688965	T	T	47688965	3	4	81	1	0	0	0	0	1	0	0	0	3930	536	19	1	941	1	CSE1L	20	47688965	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08		47688965	15336555	73	5542											
UCKL1	54963	broad.mit.edu	37	chr20	62571796	62571796	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgcagtccatgaggatcaCgtggtcatcgctgatgtcct	13	10	2	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr20:62571796C>T	uc010gkn.2	-	13	1388	c.1345G>A	c.(1345-1347)GTG>ATG	p.V449M	UCKL1_uc002yhj.2_Missense_Mutation_p.V92M|UCKL1_uc011abm.1_Missense_Mutation_p.V434M|UCKL1_uc011abn.1_RNA	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	449					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					ATGAGGATCACGTGGTCATCG	0.677													T	62571796	T	T	62571796	3	4	81	1	0	0	0	0	1	0	0	0	16922	536	19	1	313	1	UCKL1	20	62571796	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	14882831	62571796	453724	74	5543											
KRTAP10-4	386672	broad.mit.edu	37	chr21	45993777	45993777	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcgcccccagctgctgcGccccggccccctgcctgagc	12	22	0	1			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr21:45993777G>A	uc002zfk.1	+	1	172	c.142G>A	c.(142-144)GCC>ACC	p.A48T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	48	3.|36 X 5 AA repeats of C-C-X(3).					keratin filament					0						CAGCTGCTGCGCCCCGGCCCC	0.701													A	45993777	A	A	45993777	3	1	81	1	0	0	0	0	1	0	0	0	8511	1087	38	1	144	1	KRTAP10-4	21	45993777	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08		45993777	2136118	75	5544											
BPIL2	254240	broad.mit.edu	37	chr22	32829708	32829708	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaccctgagcacttacccGggagagcacgttgccaaggc	11	14	0	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr22:32829708G>A	uc003amn.2	-	9	976	c.976C>T	c.(976-978)CGG>TGG	p.R326W	BPIL2_uc010gwo.2_Missense_Mutation_p.R140W|BPIL2_uc011amb.1_Missense_Mutation_p.R50W	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	326						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						GCACTTACCCGGGAGAGCACG	0.418													A	32829708	A	A	32829708	3	1	81	1	0	0	0	0	1	0	0	0	1492	1115	39	2	575	2	BPIL2	22	32829708	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08		32829708	18474858	76	5545											
CACNA1I	8911	broad.mit.edu	37	chr22	40080363	40080363	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ctctcctgcccatgccagccGagttcttccaccctgcagtg	8	18	2	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr22:40080363G>T	uc003ayc.2	+	36	5887	c.5887G>T	c.(5887-5889)GAG>TAG	p.E1963*	CACNA1I_uc003ayd.2_Nonsense_Mutation_p.E1928*|CACNA1I_uc003aye.2_Nonsense_Mutation_p.E1878*|CACNA1I_uc003ayf.2_Nonsense_Mutation_p.E1843*	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1963	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CATGCCAGCCGAGTTCTTCCA	0.637													T	40080363	T	T	40080363	4	4	81	1	0	0	0	0	0	1	0	0	2546	1059	37	5	6029	5	CACNA1I	22	40080363	Nonsense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08	7250655	40080363	11224203	77	5546											
CSDC2	27254	broad.mit.edu	37	chr22	41969718	41969718	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctgtaagcagttctcacgctCacagggccatggcttcatca	9	13	4	0			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chr22:41969718C>T	uc003bak.1	+	3	533	c.236C>T	c.(235-237)TCA>TTA	p.S79L		NM_014460	NP_055275	Q9Y534	CSDC2_HUMAN	RNA-binding protein pippin	79	CSD.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|RNA binding				0						TTCTCACGCTCACAGGGCCAT	0.612													T	41969718	T	T	41969718	3	4	81	1	0	0	0	0	1	0	0	0	3928	838	29	3	242	3	CSDC2	22	41969718	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	1889355	41969718	9334848	78	5547											
P2RY8	286530	broad.mit.edu	37	chrX	1584460	1584460	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggcctcggagcgcacggacGtggtcctggcggagaagagg	19	11	0	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chrX:1584460G>A	uc004cpz.2	-	2	1240	c.992C>T	c.(991-993)ACG>ATG	p.T331M		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	331	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCGCACGGACGTGGTCCTGGC	0.701			T	CRLF2	B-ALL|Downs associated ALL								A	1584460	A	A	1584460	3	1	81	1	0	0	0	0	1	0	0	0	11355	1145	40	1	91	1	P2RY8	23	1584460	Missense_Mutation	SNP	G	TCGA-06-2564-01A-01D-1494-08		1584460	153686100	79	5548											
RGAG1	57529	broad.mit.edu	37	chrX	109694900	109694900	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgtccccagcactaatgaCggccctaccctctggagtga	9	14	1	2			TCGA-06-2564-01A-01D-1494-08	TCGA-06-2564-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9225f366-b08b-4c43-a09f-a16b3bcfb5aa	60224709-45d6-4a6f-8b99-9ad6515e80fa	g.chrX:109694900C>T	uc004eor.1	+	3	1301	c.1055C>T	c.(1054-1056)ACG>ATG	p.T352M	RGAG1_uc011msr.1_Missense_Mutation_p.T352M	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	352										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GCACTAATGACGGCCCTACCC	0.537													T	109694900	T	T	109694900	3	4	81	1	0	0	0	0	1	0	0	0	13274	536	19	1	1057	1	RGAG1	23	109694900	Missense_Mutation	SNP	C	TCGA-06-2564-01A-01D-1494-08	108110440	109694900	45575660	80	5549											
KIAA0562	9731	broad.mit.edu	37	chr1	3756341	3756341	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagagatatagtcagatttcCtaaagggaagaaatgcatat	10	4	1	3			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr1:3756341C>T	uc001aky.2	-	7	926	c.567_splice	c.e7-1	p.R189_splice	KIAA0562_uc010nzm.1_Splice_Site|KIAA0562_uc001akz.2_Splice_Site_p.R189_splice	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,							centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		GTCAGATTTCCTAAAGGGAAG	0.423													T	3756341	T	T	3756341	5	4	82	1	0	0	0	0	0	0	1	0	8184	695	24	3	2275	3	KIAA0562	1	3756341	Splice_Site	SNP	C	TCGA-06-2565-01A-01D-1494-08		3756341	245494280	1	5550											
LRRC40	55631	broad.mit.edu	37	chr1	70611582	70611582	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatggatttccatccagtagTaatgttctaaacaaaagaga	7	6	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr1:70611582T>C	uc001der.1	-	15	1762	c.1710A>G	c.(1708-1710)TTA>TTG	p.L570L		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	570	LRR 20.									ovary(1)	1						CATCCAGTAGTAATGTTCTAA	0.313													C	70611582	C	C	70611582	2	2	82	1	0	0	0	0	0	0	0	1	8998	1635	57	4		4	LRRC40	1	70611582	Silent	SNP	T	TCGA-06-2565-01A-01D-1494-08	66855241	70611582	178639039	2	5551											
IQGAP3	128239	broad.mit.edu	37	chr1	156497822	156497822	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactttcctgcctcatctccCggcgtgatgtcaaagatgac	8	13	3	3	rs144640189	byFrequency	TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr1:156497822C>T	uc001fpf.2	-	37	4779	c.4704G>A	c.(4702-4704)CCG>CCA	p.P1568P		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1568					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTCATCTCCCGGCGTGATGT	0.512													T	156497822	T	T	156497822	2	4	82	1	0	0	0	0	0	0	0	1	7816	639	23	2		2	IQGAP3	1	156497822	Silent	SNP	C	TCGA-06-2565-01A-01D-1494-08	85886240	156497822	92752799	3	5552											
SELP	6403	broad.mit.edu	37	chr1	169562878	169562878	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctttcttagcaaagccaggAgcgtcccacccattatcaga	8	13	2	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr1:169562878A>G	uc001ggi.3	-	14	2437	c.2372T>C	c.(2371-2373)CTC>CCC	p.L791P	SELP_uc001ggh.2_Intron|SELP_uc009wvr.2_Missense_Mutation_p.L790P	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	791	Helical; (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CAAAGCCAGGAGCGTCCCACC	0.413													G	169562878	G	G	169562878	3	3	82	1	0	0	0	0	1	0	0	0	14019	304	11	4	132	4	SELP	1	169562878	Missense_Mutation	SNP	A	TCGA-06-2565-01A-01D-1494-08	13065056	169562878	79687743	4	5553											
CRB1	23418	broad.mit.edu	37	chr1	197407699	197407699	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagcagattaccctcaacaGtctgtgggaatgagaagaca	11	8	2	4			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr1:197407699G>A	uc001gtz.2	+	10	3907	c.3772G>A	c.(3772-3774)GTC>ATC	p.V1258I	CRB1_uc010poz.1_Missense_Mutation_p.V1234I|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.V1146I|CRB1_uc010ppb.1_Missense_Mutation_p.V722I|CRB1_uc010ppd.1_Missense_Mutation_p.V739I|CRB1_uc001gub.1_Missense_Mutation_p.V907I	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1258	Extracellular (Potential).|EGF-like 18.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ACCCTCAACAGTCTGTGGGAA	0.413													A	197407699	A	A	197407699	3	1	82	1	0	0	0	0	1	0	0	0	3848	1029	36	3	3810	3	CRB1	1	197407699	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	27844821	197407699	51842922	5	5554											
CACNA1S	779	broad.mit.edu	37	chr1	201028369	201028369	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctccagggtgaagatgataGtgaaggccacattgaggatg	14	6	1	5			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr1:201028369G>A	uc001gvv.2	-	27	3700	c.3473C>T	c.(3472-3474)ACT>ATT	p.T1158I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1158	IV.|Helical; Name=S2 of repeat IV; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GAAGATGATAGTGAAGGCCAC	0.597													A	201028369	A	A	201028369	3	1	82	1	0	0	0	0	1	0	0	0	2547	1029	36	3	2220	3	CACNA1S	1	201028369	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	3620670	201028369	48222252	6	5555											
OBSCN	84033	broad.mit.edu	37	chr1	228473808	228473808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgcacatcatcgaggacctgGaggatgtggatgtgcaggag	16	7	1	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr1:228473808G>A	uc009xez.1	+	34	9078	c.9034G>A	c.(9034-9036)GAG>AAG	p.E3012K	OBSCN_uc001hsn.2_Missense_Mutation_p.E3012K|OBSCN_uc001hsq.1_Missense_Mutation_p.E268K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3012	Ig-like 30.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CGAGGACCTGGAGGATGTGGA	0.647													A	228473808	A	A	228473808	3	1	82	1	0	0	0	0	1	0	0	0	10812	1175	41	3	9164	3	OBSCN	1	228473808	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	27445439	228473808	20776813	7	5556											
TRIM58	25893	broad.mit.edu	37	chr1	248028031	248028031	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtggaaatgcagaggcagCgcttcagattggagtttgag	15	5	1	3			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr1:248028031C>T	uc001ido.2	+	3	589	c.541C>T	c.(541-543)CGC>TGC	p.R181C		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	181						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCAGAGGCAGCGCTTCAGATT	0.592													T	248028031	T	T	248028031	3	4	82	1	0	0	0	0	1	0	0	0	16528	768	27	1	551	1	TRIM58	1	248028031	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	19554223	248028031	1222590	8	5557											
GALNT14	79623	broad.mit.edu	37	chr2	31178570	31178570	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcagagtggtgccctgggCgatgtcagcgccccgaatcc	14	13	2	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr2:31178570C>T	uc002rnr.2	-	6	1187	c.568G>A	c.(568-570)GCC>ACC	p.A190T	GALNT14_uc002rnq.2_Missense_Mutation_p.A170T|GALNT14_uc002rns.2_Missense_Mutation_p.A195T|GALNT14_uc010ymr.1_Missense_Mutation_p.A155T|GALNT14_uc010ezo.1_Missense_Mutation_p.A157T|GALNT14_uc010ezp.1_Missense_Mutation_p.A161T	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	190	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GTGCCCTGGGCGATGTCAGCG	0.597													T	31178570	T	T	31178570	3	4	82	1	0	0	0	0	1	0	0	0	6212	768	27	1	1130	1	GALNT14	2	31178570	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08		31178570	212020803	9	5558											
LTBP1	4052	broad.mit.edu	37	chr2	33482448	33482448	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catgtaggtaaaggacctgtAtttgtcaagccaaagaacac	9	8	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr2:33482448A>G	uc002ros.2	+	12	2265	c.2265A>G	c.(2263-2265)GTA>GTG	p.V755V	LTBP1_uc002rot.2_Silent_p.V429V|LTBP1_uc002rou.2_Silent_p.V429V|LTBP1_uc002rov.2_Intron|LTBP1_uc010ymz.1_Silent_p.V429V|LTBP1_uc010yna.1_Intron	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	755					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGGACCTGTATTTGTCAAGC	0.502													G	33482448	G	G	33482448	2	3	82	1	0	0	0	0	0	0	0	1	9073	436	16	4		4	LTBP1	2	33482448	Silent	SNP	A	TCGA-06-2565-01A-01D-1494-08	2303878	33482448	209716925	10	5559											
ZAP70	7535	broad.mit.edu	37	chr2	98351132	98351132	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgacattgaacttggctgcGgcaactttggctcagtgcgc	12	11	1	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr2:98351132G>A	uc002syd.1	+	9	1246	c.1039G>A	c.(1039-1041)GGC>AGC	p.G347S	ZAP70_uc010yvf.1_3'UTR|ZAP70_uc002sye.1_Missense_Mutation_p.G237S|ZAP70_uc002syf.1_Missense_Mutation_p.G40S	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	347	Protein kinase.|ATP (By similarity).				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						ACTTGGCTGCGGCAACTTTGG	0.622													A	98351132	A	A	98351132	3	1	82	1	0	0	0	0	1	0	0	0	17511	1116	39	2	1065	2	ZAP70	2	98351132	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	64868684	98351132	144848241	11	5560											
GCC2	9648	broad.mit.edu	37	chr2	109092033	109092033	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agaaaaggaggagaaaataaAtaagataaaattagttgccg	10	2	0	3			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr2:109092033A>G	uc002tec.2	+	8	3057	c.2903A>G	c.(2902-2904)AAT>AGT	p.N968S	GCC2_uc002ted.2_Missense_Mutation_p.N867S	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	968	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						GAGAAAATAAATAAGATAAAA	0.299													G	109092033	G	G	109092033	3	3	82	1	0	0	0	0	1	0	0	0	6286	101	4	4	2933	4	GCC2	2	109092033	Missense_Mutation	SNP	A	TCGA-06-2565-01A-01D-1494-08	10740901	109092033	134107340	12	5561											
KIF5C	3800	broad.mit.edu	37	chr2	149866823	149866823	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcgtatcaaggaggccgtgCgggccaagaacatggccaga	14	10	1	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr2:149866823C>A	uc010zbu.1	+	24	3093	c.2725C>A	c.(2725-2727)CGG>AGG	p.R909R	KIF5C_uc002tws.1_RNA|KIF5C_uc002twu.1_Silent_p.R191R	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	909	|Globular.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		GGAGGCCGTGCGGGCCAAGAA	0.632													A	149866823	A	A	149866823	2	1	82	1	0	0	0	0	0	0	0	1	8307	759	27	5		5	KIF5C	2	149866823	Silent	SNP	C	TCGA-06-2565-01A-01D-1494-08	40774790	149866823	93332550	13	5562											
ZNF860	344787	broad.mit.edu	37	chr3	32030908	32030908	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ggaaagatattcatgactttGagtttcaatggcaagaagac	10	5	2	5			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr3:32030908G>C	uc011axg.1	+	2	886	c.337G>C	c.(337-339)GAG>CAG	p.E113Q		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	113					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCATGACTTTGAGTTTCAATG	0.388													C	32030908	C	C	32030908	3	2	82	1	0	0	0	0	1	0	0	0	18191	1291	45	5	339	5	ZNF860	3	32030908	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08		32030908	165991522	14	5563											
SCN5A	6331	broad.mit.edu	37	chr3	38639416	38639416	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaggtagcgctgggcgagaCggttccagcatggtggacac	16	10	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr3:38639416C>T	uc003cio.2	-	14	2260	c.2066G>A	c.(2065-2067)CGT>CAT	p.R689H	SCN5A_uc003cin.2_Missense_Mutation_p.R689H|SCN5A_uc003cil.3_Missense_Mutation_p.R689H|SCN5A_uc010hhi.2_Missense_Mutation_p.R689H|SCN5A_uc010hhk.2_Missense_Mutation_p.R689H|SCN5A_uc011ayr.1_Missense_Mutation_p.R689H|SCN5A_uc010hhj.1_Missense_Mutation_p.R300H	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	689					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CTGGGCGAGACGGTTCCAGCA	0.537													T	38639416	T	T	38639416	3	4	82	1	0	0	0	0	1	0	0	0	13922	536	19	1	4044	1	SCN5A	3	38639416	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	6608508	38639416	159383014	15	5564											
GPR27	2850	broad.mit.edu	37	chr3	71804047	71804047	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaagacggagaagaggctgTgcaagatgttctacgccgtc	13	9	2	4			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr3:71804047T>G	uc011bge.1	+	1	847	c.847T>G	c.(847-849)TGC>GGC	p.C283G	EIF4E3_uc003dox.2_5'Flank|EIF4E3_uc011bgd.1_5'Flank|EIF4E3_uc010hoc.2_5'Flank	NM_018971	NP_061844	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	283	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		GAAGAGGCTGTGCAAGATGTT	0.552													G	71804047	G	G	71804047	3	3	82	1	0	0	0	0	1	0	0	0	6685	1696	59	5	849	5	GPR27	3	71804047	Missense_Mutation	SNP	T	TCGA-06-2565-01A-01D-1494-08	33164631	71804047	126218383	16	5565											
CD96	10225	broad.mit.edu	37	chr3	111356989	111356989	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacaactgccaatggatctaCgaaaactaatcacgtccata	5	12	2	0	rs140955483		TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr3:111356989C>T	uc003dxw.2	+	13	1669	c.1499C>T	c.(1498-1500)ACG>ATG	p.T500M	CD96_uc003dxx.2_Missense_Mutation_p.T484M|CD96_uc010hpy.1_Missense_Mutation_p.T483M	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	500	Extracellular (Potential).|Pro/Ser/Thr-rich.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						AATGGATCTACGAAAACTAAT	0.338									Opitz_Trigonocephaly_syndrome				T	111356989	T	T	111356989	3	4	82	1	0	0	0	0	1	0	0	0	3048	536	19	1	1549	1	CD96	3	111356989	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	39552942	111356989	86665441	17	5566											
TNK2	10188	broad.mit.edu	37	chr3	195599202	195599203	+	Frame_Shift_Del	DEL	CT	-	-													ggggtcactgtcgccatgccCtgtgtggatgaagctgttct							TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr3:195599202_195599203delCT	uc003fvu.1	-	10	1938_1939	c.1395_1396delAG	c.(1393-1398)ACAGGGfs	p.T465fs	TNK2_uc003fvq.1_5'Flank|TNK2_uc003fvr.1_5'UTR|TNK2_uc003fvs.1_Frame_Shift_Del_p.T497fs|TNK2_uc003fvt.1_Frame_Shift_Del_p.T528fs|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Frame_Shift_Del_p.T295fs	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	465_466	CRIB.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	TCGCCATGCCCTGTGTGGATGA	0.673													-	195599203	-	-	195599202	7	5	82	1	0	1	0	1	0	0	0	0	16315	681	24	0	1793	0	TNK2	3	195599202	Frame_Shift_Del	DEL	CT	TCGA-06-2565-01A-01D-1494-08	84242213	195599202	2423228	18	5567											
PKD2	5311	broad.mit.edu	37	chr4	88987002	88987002	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaccgaacatgaacatcagCagatgagagacgacttggag	12	8	1	5			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr4:88987002C>T	uc003hre.2	+	12	2395	c.2329C>T	c.(2329-2331)CAG>TAG	p.Q777*	PKD2_uc011cdf.1_Nonsense_Mutation_p.Q195*|PKD2_uc011cdg.1_Nonsense_Mutation_p.Q103*|PKD2_uc011cdh.1_5'UTR	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	777	EF-hand.|EF-hand domain.|Cytoplasmic (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		TGAACATCAGCAGATGAGAGA	0.443													T	88987002	T	T	88987002	4	4	82	1	0	0	0	0	0	1	0	0	11966	711	25	3	2375	3	PKD2	4	88987002	Nonsense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08		88987002	102167274	19	5568											
TERT	7015	broad.mit.edu	37	chr5	1279521	1279521	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcgcccaggaggccggggCgccgcgcccgctcgtagttg	18	15	0	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr5:1279521C>T	uc003jcb.1	-	5	2073	c.2015G>A	c.(2014-2016)CGC>CAC	p.R672H	TERT_uc003jbz.1_5'UTR|TERT_uc003jca.1_Missense_Mutation_p.R672H|TERT_uc003jcc.1_Missense_Mutation_p.R672H|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	672	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity	p.R672H(1)		lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GAGGCCGGGGCGCCGCGCCCG	0.697									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				T	1279521	T	T	1279521	3	4	82	1	0	0	0	0	1	0	0	0	15761	768	27	1	1431	1	TERT	5	1279521	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08		1279521	179635739	20	5569											
ADAMTS16	170690	broad.mit.edu	37	chr5	5222920	5222920	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggacatctgtaaagccctgTggtgccatcgtattggaagg	13	8	1	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr5:5222920T>G	uc003jdl.2	+	11	1762	c.1624T>G	c.(1624-1626)TGG>GGG	p.W542G	ADAMTS16_uc003jdk.1_Missense_Mutation_p.W542G|ADAMTS16_uc003jdj.1_Missense_Mutation_p.W542G	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	542	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TAAAGCCCTGTGGTGCCATCG	0.358													G	5222920	G	G	5222920	3	3	82	1	0	0	0	0	1	0	0	0	261	1696	59	5	1666	5	ADAMTS16	5	5222920	Missense_Mutation	SNP	T	TCGA-06-2565-01A-01D-1494-08	3943399	5222920	175692340	21	5570											
BASP1	10409	broad.mit.edu	37	chr5	17275820	17275820	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccaggagaccaaaagtgaCggggccccagcttcagactc	12	14	1	3			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr5:17275820C>T	uc003jfx.2	+	2	674	c.495C>T	c.(493-495)GAC>GAT	p.D165D		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	165					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						CCAAAAGTGACGGGGCCCCAG	0.582													T	17275820	T	T	17275820	2	4	82	1	0	0	0	0	0	0	0	1	1317	535	19	1		1	BASP1	5	17275820	Silent	SNP	C	TCGA-06-2565-01A-01D-1494-08	12052900	17275820	163639440	22	5571											
FBN2	2201	broad.mit.edu	37	chr5	127728882	127728882	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccacaccggctcccccaaCgccaggagaaaagccattgc	8	19	0	1	rs138046782		TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr5:127728882C>T	uc003kuu.2	-	10	1850	c.1411G>A	c.(1411-1413)GTT>ATT	p.V471I	FBN2_uc003kuv.2_Missense_Mutation_p.V438I	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	471					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCTCCCCCAACGCCAGGAGAA	0.577													T	127728882	T	T	127728882	3	4	82	1	0	0	0	0	1	0	0	0	5703	536	19	1	7551	1	FBN2	5	127728882	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	110453062	127728882	53186378	23	5572											
PCDHGA1	56114	broad.mit.edu	37	chr5	140711985	140711985	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctaccggcgtggagctggcGcccctctccgcagagcccgg	14	17	2	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr5:140711985G>A	uc003lji.1	+	1	1734	c.1734G>A	c.(1732-1734)GCG>GCA	p.A578A	PCDHGA1_uc011dan.1_Silent_p.A578A	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	578	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGCTGGCGCCCCTCTCCG	0.657													A	140711985	A	A	140711985	2	1	82	1	0	0	0	0	0	0	0	1	11550	1074	38	1		1	PCDHGA1	5	140711985	Silent	SNP	G	TCGA-06-2565-01A-01D-1494-08	12983103	140711985	40203275	24	5573											
SPINK6	404203	broad.mit.edu	37	chr5	147585617	147585617	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggtgtcttcagtcagggagGacaggtcagtgcctattttt	13	7	4	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr5:147585617G>A	uc003lpa.2	+	2	333	c.77G>A	c.(76-78)GGA>GAA	p.G26E		NM_205841	NP_995313	Q6UWN8	ISK6_HUMAN	serine protease inhibitor, Kazal type 6	26	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCAGGGAGGACAGGTCAGT	0.383													A	147585617	A	A	147585617	3	1	82	1	0	0	0	0	1	0	0	0	15062	1174	41	3	83	3	SPINK6	5	147585617	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	6873632	147585617	33329643	25	5574											
GPR116	221395	broad.mit.edu	37	chr6	46826170	46826170	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaacagacattcttcctcGtatagacttcccggggctgg	10	13	1	2	rs141322343	byFrequency	TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr6:46826170G>A	uc003oyo.3	-	17	3759	c.3470C>T	c.(3469-3471)ACG>ATG	p.T1157M	GPR116_uc011dwj.1_Missense_Mutation_p.T712M|GPR116_uc011dwk.1_Missense_Mutation_p.T586M|GPR116_uc003oyp.3_Missense_Mutation_p.T1015M|GPR116_uc003oyq.3_Missense_Mutation_p.T1157M|GPR116_uc010jzi.1_Missense_Mutation_p.T829M	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1157	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			ATTCTTCCTCGTATAGACTTC	0.557													A	46826170	A	A	46826170	3	1	82	1	0	0	0	0	1	0	0	0	6633	1145	40	1	590	1	GPR116	6	46826170	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08		46826170	124288897	26	5575											
EGFR	1956	broad.mit.edu	37	chr7	55211080	55211080	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggaaaacctgcagatcatcaGaggaaatatgtactacgaaa	9	7	2	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr7:55211080G>A	uc003tqk.2	+	3	569	c.323G>A	c.(322-324)AGA>AAA	p.R108K	EGFR_uc003tqh.2_Missense_Mutation_p.R108K|EGFR_uc003tqi.2_Missense_Mutation_p.R108K|EGFR_uc003tqj.2_Missense_Mutation_p.R108K|EGFR_uc010kzg.1_Missense_Mutation_p.R108K|EGFR_uc011kco.1_Missense_Mutation_p.R55K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	108	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R108K(7)|p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGATCATCAGAGGAAATATG	0.423		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55211080	A	A	55211080	3	1	82	1	0	0	0	0	1	0	0	0	4967	942	33	3	333	3	EGFR	7	55211080	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08		55211080	103927583	27	5576											
EGFR	1956	broad.mit.edu	37	chr7	55240690	55240690	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ttccaggcctaagatcccgtCcatcgccactgggatggtgg	12	13	0	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr7:55240690C>G	uc003tqk.2	+	17	2180	c.1934C>G	c.(1933-1935)TCC>TGC	p.S645C	EGFR_uc010kzg.1_Missense_Mutation_p.S600C|EGFR_uc011kco.1_Missense_Mutation_p.S592C	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	645	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAGATCCCGTCCATCGCCACT	0.612		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			G	55240690	G	G	55240690	3	3	82	1	0	0	0	0	1	0	0	0	4967	855	30	5	2264	5	EGFR	7	55240690	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	29610	55240690	103897973	28	5577											
TYW1	55253	broad.mit.edu	37	chr7	66482862	66482862	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcaaaaatgttgacaagtGgctctggatgcttggcgcgc	14	8	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr7:66482862G>A	uc003tvn.2	+	6	742	c.593G>A	c.(592-594)TGG>TAG	p.W198*	TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	198	FMN (By similarity).|Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				GTTGACAAGTGGCTCTGGATG	0.512													A	66482862	A	A	66482862	4	1	82	1	0	0	0	0	0	1	0	0	16815	1357	47	3	615	3	TYW1	7	66482862	Nonsense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	11242172	66482862	92655801	29	5578											
CD36	948	broad.mit.edu	37	chr7	80290463	80290463	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagcccaatggtgccatcttCgaaccttcactatcagttgg	8	13	3	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr7:80290463C>T	uc003uhc.2	+	8	1050	c.366C>T	c.(364-366)TTC>TTT	p.F122F	CD36_uc003uhd.3_Silent_p.F122F|CD36_uc011kgv.1_Silent_p.F46F|CD36_uc003uhe.3_Silent_p.F122F|CD36_uc003uhf.3_Silent_p.F122F|CD36_uc003uhg.3_Silent_p.F122F|CD36_uc003uhh.3_Silent_p.F122F	NM_001127444	NP_001120916	P16671	CD36_HUMAN	CD36 antigen	122	Extracellular (Potential).				cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			ovary(1)	1						GTGCCATCTTCGAACCTTCAC	0.428													T	80290463	T	T	80290463	2	4	82	1	0	0	0	0	0	0	0	1	3007	883	31	2		2	CD36	7	80290463	Silent	SNP	C	TCGA-06-2565-01A-01D-1494-08	13807601	80290463	78848200	30	5579											
SEMA3E	9723	broad.mit.edu	37	chr7	83034830	83034830	+	Frame_Shift_Del	DEL	C	-	-													tctggtaggtagcaaaaaaaCgtcctctgaaaaattaaagg							TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr7:83034830delC	uc003uhy.1	-	9	1400	c.934delG	c.(934-936)GTTfs	p.V312fs		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	312	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				AGCAAAAAAACGTCCTCTGAA	0.313													-	83034830	-	-	83034830	7	5	82	1	0	1	0	1	0	0	0	0	14028	536	19	0	1429	0	SEMA3E	7	83034830	Frame_Shift_Del	DEL	C	TCGA-06-2565-01A-01D-1494-08	2744367	83034830	76103833	31	5580											
ANK1	286	broad.mit.edu	37	chr8	41521227	41521227	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtgaattgctcctctgtcaCctgctcccctggaatattct	7	14	3	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr8:41521227C>T	uc003xok.2	-	40	5512	c.5428G>A	c.(5428-5430)GTG>ATG	p.V1810M	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.V964M|ANK1_uc003xoi.2_Missense_Mutation_p.V1810M|ANK1_uc003xoj.2_Missense_Mutation_p.V1810M|ANK1_uc003xol.2_Missense_Mutation_p.V1648M|ANK1_uc003xom.2_Missense_Mutation_p.V1851M|ANK1_uc011lcl.1_Missense_Mutation_p.V85M|ANK1_uc003xod.2_Missense_Mutation_p.V85M|ANK1_uc003xoc.2_Missense_Mutation_p.V85M|ANK1_uc003xof.2_Missense_Mutation_p.V85M	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1810	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCCTCTGTCACCTGCTCCCCT	0.537													T	41521227	T	T	41521227	3	4	82	1	0	0	0	0	1	0	0	0	620	507	18	3	332	3	ANK1	8	41521227	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08		41521227	104842795	32	5581											
RP1	6101	broad.mit.edu	37	chr8	55537454	55537454	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgacagttgagatgaaagttCgattcagaataaaagaggaa	11	3	1	5			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr8:55537454C>T	uc003xsd.1	+	4	1160	c.1012C>T	c.(1012-1014)CGA>TGA	p.R338*	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	338					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GATGAAAGTTCGATTCAGAAT	0.328													T	55537454	T	T	55537454	4	4	82	1	0	0	0	0	0	1	0	0	13532	876	31	2	1022	2	RP1	8	55537454	Nonsense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	14016227	55537454	90826568	33	5582											
SLCO5A1	81796	broad.mit.edu	37	chr8	70650427	70650427	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgcttaagatcctgacagctGctcttggtaggtctacaaaa	9	9	2	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr8:70650427G>T	uc003xyl.2	-	5	1978	c.1271C>A	c.(1270-1272)GCA>GAA	p.A424E	SLCO5A1_uc010lzb.2_Intron|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.A424E|SLCO5A1_uc010lzc.2_Intron	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	424	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCTGACAGCTGCTCTTGGTAG	0.348													T	70650427	T	T	70650427	3	4	82	1	0	0	0	0	1	0	0	0	14731	1319	46	5	1299	5	SLCO5A1	8	70650427	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	15112973	70650427	75713595	34	5583											
KLF10	7071	broad.mit.edu	37	chr8	103662460	103662460	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctgatagatggcgccggGcatgcttggtcaaatggtca	15	8	2	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr8:103662460G>A	uc011lhk.1	-	4	1497	c.1343C>T	c.(1342-1344)GCC>GTC	p.A448V	KLF10_uc011lhj.1_Missense_Mutation_p.A437V	NM_005655	NP_005646	Q13118	KLF10_HUMAN	Kruppel-like factor 10 isoform a	448	C2H2-type 3.				cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			ATGGCGCCGGGCATGCTTGGT	0.542													A	103662460	A	A	103662460	3	1	82	1	0	0	0	0	1	0	0	0	8338	1203	42	3	103	3	KLF10	8	103662460	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	33012033	103662460	42701562	35	5584											
HEMGN	55363	broad.mit.edu	37	chr9	100698486	100698486	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgatgtttccttttcatgcActtcagcttttctttttcta	5	9	4	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr9:100698486A>G	uc004axy.2	-	2	248	c.140T>C	c.(139-141)GTG>GCG	p.V47A	HEMGN_uc004axz.2_Missense_Mutation_p.V47A	NM_197978	NP_932095	Q9BXL5	HEMGN_HUMAN	hemogen	47	Necessary for nuclear localization.				cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CTTTTCATGCACTTCAGCTTT	0.299													G	100698486	G	G	100698486	3	3	82	1	0	0	0	0	1	0	0	0	7050	159	6	4	1326	4	HEMGN	9	100698486	Missense_Mutation	SNP	A	TCGA-06-2565-01A-01D-1494-08		100698486	40514945	36	5585											
BMI1	648	broad.mit.edu	37	chr10	22617609	22617609	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctcagaagtaaaatggaCatacctaatactttccaggt	6	8	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr10:22617609C>T	uc001irh.2	+	8	1191	c.552C>T	c.(550-552)GAC>GAT	p.D184D	BMI1_uc009xkg.2_Silent_p.D327D	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	184	Interaction with E4F1.				hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						GTAAAATGGACATACCTAATA	0.299													T	22617609	T	T	22617609	2	4	82	1	0	0	0	0	0	0	0	1	1455	477	17	3		3	BMI1	10	22617609	Silent	SNP	C	TCGA-06-2565-01A-01D-1494-08		22617609	112917138	37	5586											
PTCHD3	374308	broad.mit.edu	37	chr10	27702648	27702648	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagcgccgctccgccttggCcgggctccccacaggggtgt	15	16	0	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr10:27702648C>T	uc001itu.2	-	1	650	c.532G>A	c.(532-534)GCC>ACC	p.A178T		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	178					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TCCGCCTTGGCCGGGCTCCCC	0.632													T	27702648	T	T	27702648	3	4	82	1	0	0	0	0	1	0	0	0	12734	739	26	3	1787	3	PTCHD3	10	27702648	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	5085039	27702648	107832099	38	5587											
DNA2	1763	broad.mit.edu	37	chr10	70196997	70196997	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aatgcaactgccactcttctCcctatgaaaagaccaaagag	6	12	2	3			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr10:70196997C>T	uc001jof.2	-	10	1675	c.1675G>A	c.(1675-1677)GAG>AAG	p.E559K	DNA2_uc001jog.1_Missense_Mutation_p.E473K|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	473					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						CCACTCTTCTCCCTATGAAAA	0.343													T	70196997	T	T	70196997	3	4	82	1	0	0	0	0	1	0	0	0	4596	869	30	3	1813	3	DNA2	10	70196997	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	42494349	70196997	65337750	39	5588											
PTEN	5728	broad.mit.edu	37	chr10	89692818	89692818	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cccaccacagctagaacttaTcaaacccttttgtgaagatc	5	13	1	3			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr10:89692818T>C	uc001kfb.2	+	6	1333	c.302T>C	c.(301-303)ATC>ACC	p.I101T		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	101	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.I101T(7)|p.R55fs*1(4)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.H93fs*5(1)|p.I101M(1)|p.I101del(1)|p.I101N(1)|p.I101I(1)|p.I101fs*10(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTAGAACTTATCAAACCCTTT	0.368		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89692818	C	C	89692818	3	2	82	1	0	0	0	0	1	0	0	0	12738	1435	50	4	320	4	PTEN	10	89692818	Missense_Mutation	SNP	T	TCGA-06-2565-01A-01D-1494-08	19495821	89692818	45841929	40	5589											
FAM178A	55719	broad.mit.edu	37	chr10	102697209	102697209	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgcagattttaagtacAttgatggaaataacaattag	8	4	1	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr10:102697209A>G	uc001krt.3	+	10	3029	c.2487A>G	c.(2485-2487)ACA>ACG	p.T829T	FAM178A_uc001krs.2_Silent_p.T829T	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	829											0						TTTTAAGTACATTGATGGAAA	0.308													G	102697209	G	G	102697209	2	3	82	1	0	0	0	0	0	0	0	1	5503	204	8	4		4	FAM178A	10	102697209	Silent	SNP	A	TCGA-06-2565-01A-01D-1494-08	13004391	102697209	32837538	41	5590											
OR56A3	390083	broad.mit.edu	37	chr11	5969282	5969282	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgagactcaaggcagagGgtgccgtggcaaaggcccta	15	10	1	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr11:5969282G>A	uc010qzt.1	+	1	706	c.706G>A	c.(706-708)GGT>AGT	p.G236S		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAAGGCAGAGGGTGCCGTGGC	0.522													A	5969282	A	A	5969282	3	1	82	1	0	0	0	0	1	0	0	0	11134	1232	43	3	708	3	OR56A3	11	5969282	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08		5969282	129037234	42	5591											
MLL	4297	broad.mit.edu	37	chr11	118376191	118376191	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tattggggttcagcctcctcCggatccccaacttttggttt	9	12	1	0	rs147412214		TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr11:118376191C>T	uc001pta.2	+	27	9598	c.9575C>T	c.(9574-9576)CCG>CTG	p.P3192L	MLL_uc001ptb.2_Missense_Mutation_p.P3195L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3192					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CAGCCTCCTCCGGATCCCCAA	0.507			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								T	118376191	T	T	118376191	3	4	82	1	0	0	0	0	1	0	0	0	9620	652	23	2	9681	2	MLL	11	118376191	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	112406909	118376191	16630325	43	5592											
CD163L1	283316	broad.mit.edu	37	chr12	7531814	7531814	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attagcacacagaattcccaCggcaccctggacattcacct	6	15	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr12:7531814C>T	uc001qsy.2	-	9	2157	c.2131G>A	c.(2131-2133)GTG>ATG	p.V711M	CD163L1_uc010sge.1_Missense_Mutation_p.V721M	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	711	SRCR 7.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						AGAATTCCCACGGCACCCTGG	0.502													T	7531814	T	T	7531814	3	4	82	1	0	0	0	0	1	0	0	0	2968	536	19	1	2274	1	CD163L1	12	7531814	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08		7531814	126320081	44	5593											
NCKAP1L	3071	broad.mit.edu	37	chr12	54914540	54914540	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggaatctgccatgttgcGttatgccattgctttccccc	10	12	1	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr12:54914540G>A	uc001sgc.3	+	17	1767	c.1688G>A	c.(1687-1689)CGT>CAT	p.R563H	NCKAP1L_uc010sox.1_Missense_Mutation_p.R105H|NCKAP1L_uc010soy.1_Missense_Mutation_p.R513H	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	563					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GCCATGTTGCGTTATGCCATT	0.458													A	54914540	A	A	54914540	3	1	82	1	0	0	0	0	1	0	0	0	10222	1145	40	1	1754	1	NCKAP1L	12	54914540	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	47382726	54914540	78937355	45	5594											
CCT2	10576	broad.mit.edu	37	chr12	69987309	69987309	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggcaattaatttataattatCctgaacagctctttggtgct	7	7	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr12:69987309C>T	uc001svb.1	+	10	992	c.898C>T	c.(898-900)CCT>TCT	p.P300S	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Missense_Mutation_p.P300S|CCT2_uc010stl.1_Missense_Mutation_p.P253S	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	300					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TTATAATTATCCTGAACAGCT	0.264													T	69987309	T	T	69987309	3	4	82	1	0	0	0	0	1	0	0	0	2953	855	30	3	936	3	CCT2	12	69987309	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	15072769	69987309	63864586	46	5595											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100478382	100478382	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gcaataactcattggcccatCcattttttgttttggttgca	7	9	1	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr12:100478382C>G	uc001tgq.2	-	10	1389	c.1160G>C	c.(1159-1161)GGA>GCA	p.G387A	UHRF1BP1L_uc001tgr.2_Missense_Mutation_p.G387A|UHRF1BP1L_uc001tgp.2_Missense_Mutation_p.G37A	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	387										ovary(2)	2						ATTGGCCCATCCATTTTTTGT	0.353													G	100478382	G	G	100478382	3	3	82	1	0	0	0	0	1	0	0	0	16966	855	30	5	3306	5	UHRF1BP1L	12	100478382	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	30491073	100478382	33373513	47	5596											
NOS1	4842	broad.mit.edu	37	chr12	117655934	117655934	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	acttcgtacgttcgcagggtGactccaaaaatatcctcatg	8	11	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr12:117655934G>A	uc001twm.1	-	28	4892	c.4206C>T	c.(4204-4206)GTC>GTT	p.V1402V		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1402					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTCGCAGGGTGACTCCAAAAA	0.483													A	117655934	A	A	117655934	2	1	82	1	0	0	0	0	0	0	0	1	10541	1277	45	3		3	NOS1	12	117655934	Silent	SNP	G	TCGA-06-2565-01A-01D-1494-08	17177552	117655934	16195961	48	5597											
SOCS4	122809	broad.mit.edu	37	chr14	55510054	55510054	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacagaaactgcaagatgccGtggggcagtgttttccaata	11	8	0	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr14:55510054G>A	uc001xbo.2	+	3	860	c.295G>A	c.(295-297)GTG>ATG	p.V99M	SOCS4_uc001xbp.2_Missense_Mutation_p.V99M	NM_199421	NP_955453	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	99					intracellular signal transduction|negative regulation of signal transduction|regulation of growth					ovary(1)|kidney(1)	2						GCAAGATGCCGTGGGGCAGTG	0.423													A	55510054	A	A	55510054	3	1	82	1	0	0	0	0	1	0	0	0	14916	1145	40	1	297	1	SOCS4	14	55510054	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08		55510054	51839486	49	5598											
DACT1	51339	broad.mit.edu	37	chr14	59113060	59113060	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtcaggctccaccggggccaCaggaacatgggcgtcgtgaa	15	12	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr14:59113060C>A	uc001xdw.2	+	4	1883	c.1719C>A	c.(1717-1719)CAC>CAA	p.H573Q	DACT1_uc010trv.1_Missense_Mutation_p.H292Q|DACT1_uc001xdx.2_Missense_Mutation_p.H536Q|DACT1_uc010trw.1_Missense_Mutation_p.H292Q	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	573					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						ACCGGGGCCACAGGAACATGG	0.657													A	59113060	A	A	59113060	3	1	82	1	0	0	0	0	1	0	0	0	4222	477	17	5	1733	5	DACT1	14	59113060	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	3603006	59113060	48236480	50	5599											
ZFYVE26	23503	broad.mit.edu	37	chr14	68274397	68274397	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcagggccctgcaaagcccGcaatgcctttcgaatgaggt	11	12	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr14:68274397G>A	uc001xka.2	-	5	743	c.604C>T	c.(604-606)CGG>TGG	p.R202W	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.R202W|ZFYVE26_uc010tta.1_Missense_Mutation_p.R202W	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	202					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TGCAAAGCCCGCAATGCCTTT	0.612													A	68274397	A	A	68274397	3	1	82	1	0	0	0	0	1	0	0	0	17665	1086	38	1	7167	1	ZFYVE26	14	68274397	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	9161337	68274397	39075143	51	5600											
CKB	1152	broad.mit.edu	37	chr14	103986328	103986328	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctctgagaagcccaggcggTcagcgttggagacgtcgaag	15	11	2	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr14:103986328T>G	uc001ynf.1	-	8	1099	c.1019A>C	c.(1018-1020)GAC>GCC	p.D340A	CKB_uc001yne.1_Missense_Mutation_p.D162A|CKB_uc010awr.1_Missense_Mutation_p.D271A	NM_001823	NP_001814	P12277	KCRB_HUMAN	brain creatine kinase	340	Phosphagen kinase C-terminal.			D->E: No change in activity.	creatine metabolic process	cytosol	ATP binding|creatine kinase activity				0		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	GCCCAGGCGGTCAGCGTTGGA	0.662													G	103986328	G	G	103986328	3	3	82	1	0	0	0	0	1	0	0	0	3446	1667	58	5	130	5	CKB	14	103986328	Missense_Mutation	SNP	T	TCGA-06-2565-01A-01D-1494-08	35711931	103986328	3363212	52	5601											
GJD2	57369	broad.mit.edu	37	chr15	35044812	35044812	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacagccagcttgatcttgCgccatcccaggtggttgagt	12	12	1	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr15:35044812C>T	uc001zis.1	-	2	833	c.833G>A	c.(832-834)CGC>CAC	p.R278H	uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	278	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		CTTGATCTTGCGCCATCCCAG	0.512													T	35044812	T	T	35044812	3	4	82	1	0	0	0	0	1	0	0	0	6417	768	27	1	136	1	GJD2	15	35044812	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08		35044812	67486580	53	5602											
THSD4	79875	broad.mit.edu	37	chr15	71535188	71535188	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaccaggtcccccaacatgGgcctttgtaccaaagtgaca	8	15	0	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr15:71535188G>A	uc002atb.1	+	4	744	c.665G>A	c.(664-666)GGG>GAG	p.G222E	THSD4_uc002atd.1_5'UTR	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	222	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						CCCCAACATGGGCCTTTGTAC	0.597													A	71535188	A	A	71535188	3	1	82	1	0	0	0	0	1	0	0	0	15875	1232	43	3	679	3	THSD4	15	71535188	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	36490376	71535188	30996204	54	5603											
KRT27	342574	broad.mit.edu	37	chr17	38938701	38938701	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcacagagccagtgcccccGcaagagccaagtctcctgga	10	16	2	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr17:38938701G>A	uc002hvg.2	-	1	86	c.45C>T	c.(43-45)TGC>TGT	p.C15C		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	15	Head.|Gly-rich.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				CAGTGCCCCCGCAAGAGCCAA	0.582													A	38938701	A	A	38938701	2	1	82	1	0	0	0	0	0	0	0	1	8464	1079	38	1		1	KRT27	17	38938701	Silent	SNP	G	TCGA-06-2565-01A-01D-1494-08		38938701	42256509	55	5604											
MYO5B	4645	broad.mit.edu	37	chr18	47352977	47352977	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagttgctgagggtcattcCgctcttgtagttgtgcctat	12	9	2	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr18:47352977C>T	uc002leb.2	-	40	5699	c.5411G>A	c.(5410-5412)CGG>CAG	p.R1804Q	MYO5B_uc002ldz.2_Missense_Mutation_p.R374Q|MYO5B_uc002lea.2_Missense_Mutation_p.R919Q	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1804					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		AGGGTCATTCCGCTCTTGTAG	0.408													T	47352977	T	T	47352977	3	4	82	1	0	0	0	0	1	0	0	0	10079	652	23	2	139	2	MYO5B	18	47352977	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08		47352977	30724271	56	5605											
RNF152	220441	broad.mit.edu	37	chr18	59483671	59483672	+	Frame_Shift_Del	DEL	AG	-	-													aacagatctgacattccagcAgagagtcctgggacagcgtc							TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr18:59483671_59483672delAG	uc002lih.1	-	2	437_438	c.25_26delCT	c.(25-27)CTGfs	p.L9fs		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	9					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)				ACATTCCAGCAGAGAGTCCTGG	0.594													-	59483672	-	-	59483671	7	5	82	1	0	1	0	1	0	0	0	0	13453	188	7	0	589	0	RNF152	18	59483671	Frame_Shift_Del	DEL	AG	TCGA-06-2565-01A-01D-1494-08	12130694	59483671	18593577	57	5606											
ZNF407	55628	broad.mit.edu	37	chr18	72345779	72345779	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaagctggtaaaaagaatgCtggctcagcagtgaccatgt	12	7	1	3			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr18:72345779C>T	uc002llw.2	+	1	2861	c.2804C>T	c.(2803-2805)GCT>GTT	p.A935V	ZNF407_uc010xfc.1_Missense_Mutation_p.A935V|ZNF407_uc010dqu.1_Missense_Mutation_p.A935V|ZNF407_uc002llu.2_Missense_Mutation_p.A934V	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	935					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AAAAAGAATGCTGGCTCAGCA	0.453													T	72345779	T	T	72345779	3	4	82	1	0	0	0	0	1	0	0	0	17884	797	28	3	2806	3	ZNF407	18	72345779	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	12862108	72345779	5731469	58	5607											
TCF3	6929	broad.mit.edu	37	chr19	1623996	1623996	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccggaccttcttgggctgcGtgtctgttagaagcaaaagg	13	9	2	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr19:1623996G>A	uc002ltr.2	-	8	570	c.503C>T	c.(502-504)ACG>ATG	p.T168M	TCF3_uc002lto.2_5'Flank|TCF3_uc002ltt.3_Missense_Mutation_p.T168M|TCF3_uc002ltq.2_Missense_Mutation_p.T117M|TCF3_uc002lts.1_Missense_Mutation_p.T84M	NM_003200	NP_003191	P15923	TFE2_HUMAN	transcription factor 3 isoform E12	168					B cell lineage commitment|B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			lung(2)|breast(2)|ovary(1)|large_intestine(1)|skin(1)	7		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTGGGCTGCGTGTCTGTTAG	0.612			T	PBX1|HLF|TFPT	pre B-ALL								A	1623996	A	A	1623996	3	1	82	1	0	0	0	0	1	0	0	0	15691	1145	40	1	1740	1	TCF3	19	1623996	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08		1623996	57504987	59	5608											
ZNF506	440515	broad.mit.edu	37	chr19	19905675	19905675	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccacattcgtcacatttgtAgggtacatctccagtatgaa	8	10	2	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr19:19905675A>G	uc010eci.2	-	4	1169	c.1021T>C	c.(1021-1023)TAC>CAC	p.Y341H	ZNF506_uc002nog.2_Intron|ZNF506_uc002noh.3_Missense_Mutation_p.Y309H	NM_001099269	NP_001092739	Q5JVG8	ZN506_HUMAN	zinc finger protein 506 isoform 1	341	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding				0						TCACATTTGTAGGGTACATCT	0.408													G	19905675	G	G	19905675	3	3	82	1	0	0	0	0	1	0	0	0	17949	420	15	4	317	4	ZNF506	19	19905675	Missense_Mutation	SNP	A	TCGA-06-2565-01A-01D-1494-08	18281679	19905675	39223308	60	5609											
CEACAM20	125931	broad.mit.edu	37	chr19	45015149	45015149	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atctgagtgggggcatcagaGgtttgggtggtggcttccag	18	6	2	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr19:45015149G>T	uc010ejn.1	-	12	1692	c.1676C>A	c.(1675-1677)CCT>CAT	p.P559H	CEACAM20_uc010ejo.1_Missense_Mutation_p.P547H|CEACAM20_uc010ejp.1_Missense_Mutation_p.P466H|CEACAM20_uc010ejq.1_Missense_Mutation_p.P454H	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	559	Cytoplasmic (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				GGGCATCAGAGGTTTGGGTGG	0.507													T	45015149	T	T	45015149	3	4	82	1	0	0	0	0	1	0	0	0	3191	1000	35	5	122	5	CEACAM20	19	45015149	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08	25109474	45015149	14113834	61	5610											
TFPT	29844	broad.mit.edu	37	chr19	54617886	54617886	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcgatttaattcccgctggCgccgccgccgaccccgggct	12	17	0	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr19:54617886C>T	uc010yej.1	-	2	624	c.218G>A	c.(217-219)CGC>CAC	p.R73H	TFPT_uc010erd.2_Missense_Mutation_p.R73H|PRPF31_uc002qdh.2_5'Flank|PRPF31_uc010yek.1_5'Flank	NM_013342	NP_037474	P0C1Z6	TFPT_HUMAN	TCF3 (E2A) fusion partner	73					apoptosis|DNA recombination|DNA repair|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex	DNA binding|protein binding				0	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)					TTCCCGCTGGCGCCGCCGCCG	0.652			T	TCF3	pre-B ALL								T	54617886	T	T	54617886	3	4	82	1	0	0	0	0	1	0	0	0	15807	768	27	1	563	1	TFPT	19	54617886	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	9602737	54617886	4511097	62	5611											
DNTTIP1	116092	broad.mit.edu	37	chr20	44431987	44431987	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agcagatggaaaccaaaatcCtgtgaaccaattcgccggga	10	10	0	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr20:44431987C>A	uc002xpk.2	+	8	641	c.573C>A	c.(571-573)TCC>TCA	p.S191S		NM_052951	NP_443183	Q9H147	TDIF1_HUMAN	terminal deoxynucleotidyltransferase interacting	191						nucleus				ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.0122)				AACCAAAATCCTGTGAACCAA	0.493													A	44431987	A	A	44431987	2	1	82	1	0	0	0	0	0	0	0	1	4681	668	24	5		5	DNTTIP1	20	44431987	Silent	SNP	C	TCGA-06-2565-01A-01D-1494-08		44431987	18593533	63	5612											
UMODL1	89766	broad.mit.edu	37	chr21	43539379	43539379	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtcagctgcatttctcacCgccttccagaccgtgcctct	8	16	3	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr21:43539379C>T	uc002zaf.1	+	15	2634	c.2634C>T	c.(2632-2634)ACC>ACT	p.T878T	UMODL1_uc002zad.1_Silent_p.T806T|UMODL1_uc002zae.1_Silent_p.T934T|UMODL1_uc002zag.1_Silent_p.T1006T|UMODL1_uc002zal.1_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	878	Extracellular (Potential).|SEA 2.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CATTTCTCACCGCCTTCCAGA	0.567													T	43539379	T	T	43539379	2	4	82	1	0	0	0	0	0	0	0	1	16977	639	23	2		2	UMODL1	21	43539379	Silent	SNP	C	TCGA-06-2565-01A-01D-1494-08		43539379	4590516	64	5613											
DNMT3L	29947	broad.mit.edu	37	chr21	45679526	45679526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgcctaccttacatggggCgcagatccctccctcaaaca	7	17	1	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr21:45679526C>T	uc002zeg.1	-	4	704	c.220G>A	c.(220-222)GCC>ACC	p.A74T	DNMT3L_uc002zeh.1_Missense_Mutation_p.A74T	NM_175867	NP_787063	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	74	GATA-type; atypical.|ADD.				DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			skin(2)	2				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		TTACATGGGGCGCAGATCCCT	0.507													T	45679526	T	T	45679526	3	4	82	1	0	0	0	0	1	0	0	0	4678	768	27	1	979	1	DNMT3L	21	45679526	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	2140147	45679526	2450369	65	5614											
INPP5J	27124	broad.mit.edu	37	chr22	31523358	31523358	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctagggtaacaagggtggcGtgagcgtgcgcctggcggcc	18	11	0	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr22:31523358G>A	uc003aju.3	+	6	1719	c.1627G>A	c.(1627-1629)GTG>ATG	p.V543M	INPP5J_uc003ajv.3_Missense_Mutation_p.V176M|INPP5J_uc003ajs.3_Missense_Mutation_p.V176M|INPP5J_uc011alk.1_Missense_Mutation_p.V476M|INPP5J_uc010gwg.2_Missense_Mutation_p.V108M|INPP5J_uc003ajw.2_Translation_Start_Site|INPP5J_uc003ajt.3_Missense_Mutation_p.V175M|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	543	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						CAAGGGTGGCGTGAGCGTGCG	0.632													A	31523358	A	A	31523358	3	1	82	1	0	0	0	0	1	0	0	0	7759	1145	40	1	545	1	INPP5J	22	31523358	Missense_Mutation	SNP	G	TCGA-06-2565-01A-01D-1494-08		31523358	19781208	66	5615											
SFI1	9814	broad.mit.edu	37	chr22	31957290	31957290	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacagggtgtggtggagcaCgtggaggcagcgactaggac	18	8	1	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr22:31957290C>T	uc003ale.2	+	8	1070	c.677C>T	c.(676-678)ACG>ATG	p.T226M	SFI1_uc003ald.1_Missense_Mutation_p.T202M|SFI1_uc003alf.2_Missense_Mutation_p.T226M|SFI1_uc003alg.2_Missense_Mutation_p.T144M|SFI1_uc011alp.1_Missense_Mutation_p.T144M|SFI1_uc011alq.1_Missense_Mutation_p.T202M|SFI1_uc003alh.2_RNA	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	226					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						TGGTGGAGCACGTGGAGGCAG	0.572											OREG0026480	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	31957290	T	T	31957290	3	4	82	1	0	0	0	0	1	0	0	0	14156	536	19	1	703	1	SFI1	22	31957290	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	433932	31957290	19347276	67	5616											
GTSE1	51512	broad.mit.edu	37	chr22	46725343	46725343	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaccttcctctcatcgactTctgcgataccccagaagcac	6	16	2	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chr22:46725343T>C	uc011aqy.1	+	11	2227	c.2015T>C	c.(2014-2016)TTC>TCC	p.F672S	GTSE1_uc011aqz.1_Missense_Mutation_p.F519S|GTSE1_uc003bhn.2_RNA|uc011ara.1_5'Flank|uc003bho.3_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	653					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CTCATCGACTTCTGCGATACC	0.498													C	46725343	C	C	46725343	3	2	82	1	0	0	0	0	1	0	0	0	6885	1783	62	4	2053	4	GTSE1	22	46725343	Missense_Mutation	SNP	T	TCGA-06-2565-01A-01D-1494-08	14768053	46725343	4579223	68	5617											
CNKSR2	22866	broad.mit.edu	37	chrX	21450738	21450739	+	Frame_Shift_Ins	INS	-	T	T													ttataattcagaattatggcINSttggaaacagaaaatctaaa							TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chrX:21450738_21450739insT	uc004czx.1	+	3	273_274	c.237_238insT	c.(235-240)GGCTTGfs	p.G79fs	CNKSR2_uc004czw.2_Frame_Shift_Ins_p.G79fs|CNKSR2_uc011mjn.1_Frame_Shift_Ins_p.G79fs|CNKSR2_uc011mjo.1_Frame_Shift_Ins_p.G79fs	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	79_80					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						AGAATTATGGCTTGGAAACAGA	0.243													T	21450739	T	T	21450738	7	5	82	1	0	1	1	0	0	0	0	0	3607	784	28	0	247	0	CNKSR2	23	21450738	Frame_Shift_Ins	INS	-	TCGA-06-2565-01A-01D-1494-08		21450738	133819822	69	5618											
SMC1A	8243	broad.mit.edu	37	chrX	53430549	53430549	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttttcttcctcaaactccCggatgttgcgcacaccaatc	5	16	2	0			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chrX:53430549C>T	uc004dsg.2	-	15	2438	c.2369G>A	c.(2368-2370)CGG>CAG	p.R790Q	SMC1A_uc011moe.1_Missense_Mutation_p.R768Q	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	790	Potential.		R -> Q (in CDLS2).		cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CTCAAACTCCCGGATGTTGCG	0.517													T	53430549	T	T	53430549	3	4	82	1	0	0	0	0	1	0	0	0	14781	652	23	2	1376	2	SMC1A	23	53430549	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	31979811	53430549	101840011	70	5619											
SMC1A	8243	broad.mit.edu	37	chrX	53438785	53438785	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctggtctcgattgaatttctCcagctcctgggccagggtag	12	11	2	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chrX:53438785C>T	uc004dsg.2	-	7	1249	c.1180G>A	c.(1180-1182)GAG>AAG	p.E394K	SMC1A_uc011moe.1_Missense_Mutation_p.E372K|SMC1A_uc011mof.1_Missense_Mutation_p.E160K	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	394	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						TTGAATTTCTCCAGCTCCTGG	0.498													T	53438785	T	T	53438785	3	4	82	1	0	0	0	0	1	0	0	0	14781	864	30	3	2597	3	SMC1A	23	53438785	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	8236	53438785	101831775	71	5620											
FRMD7	90167	broad.mit.edu	37	chrX	131212246	131212246	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attctgacccaaaaggaaaaCgaatagttttcatgtctgat	7	7	3	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chrX:131212246C>T	uc004ewn.2	-	12	1977	c.1799G>A	c.(1798-1800)CGT>CAT	p.R600H	FRMD7_uc011muy.1_Missense_Mutation_p.R585H	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	600					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AAAAGGAAAACGAATAGTTTT	0.428													T	131212246	T	T	131212246	3	4	82	1	0	0	0	0	1	0	0	0	6055	536	19	1	349	1	FRMD7	23	131212246	Missense_Mutation	SNP	C	TCGA-06-2565-01A-01D-1494-08	77773461	131212246	24058314	72	5621											
MAP7D3	79649	broad.mit.edu	37	chrX	135301831	135301831	+	Splice_Site	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcattcttttggaagatggtCtggaaagagacagtttggtt	12	4	3	2			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chrX:135301831C>T	uc004ezt.2	-	17	2578	c.2487_splice	c.e17-1	p.R829_splice	MAP7D3_uc004ezs.2_Splice_Site_p.R793_splice|MAP7D3_uc011mwc.1_Splice_Site_p.R811_splice|MAP7D3_uc010nsa.1_Intron	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3							cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					GGAAGATGGTCTGGAAAGAGA	0.418													T	135301831	T	T	135301831	5	4	82	1	0	0	0	0	0	0	1	0	9269	927	32	3	152	3	MAP7D3	23	135301831	Splice_Site	SNP	C	TCGA-06-2565-01A-01D-1494-08	4089585	135301831	19968729	73	5622											
AFF2	2334	broad.mit.edu	37	chrX	148038125	148038125	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggagaaaccagcccctaaGggcaaacgtaagcacaaggt	12	10	0	1			TCGA-06-2565-01A-01D-1494-08	TCGA-06-2565-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c866726d-2d95-4d23-b3d4-0e28a0b3da00	0dbed582-3fce-4c02-a12d-23da05d43a3e	g.chrX:148038125G>A	uc004fcp.2	+	11	3029	c.2550G>A	c.(2548-2550)AAG>AAA	p.K850K	AFF2_uc004fcq.2_Silent_p.K840K|AFF2_uc004fcr.2_Silent_p.K811K|AFF2_uc011mxb.1_Silent_p.K815K|AFF2_uc004fcs.2_Silent_p.K817K|AFF2_uc011mxc.1_Silent_p.K491K	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	850					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCCCCTAAGGGCAAACGTA	0.517													A	148038125	A	A	148038125	2	1	82	1	0	0	0	0	0	0	0	1	357	991	35	3		3	AFF2	23	148038125	Silent	SNP	G	TCGA-06-2565-01A-01D-1494-08	12736294	148038125	7232435	74	5623											
GBP4	115361	broad.mit.edu	37	chr1	89655829	89655829	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgtccagcagctcctggagCgtgtctgtggggagcctcag	15	12	2	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr1:89655829C>T	uc001dnb.2	-	7	1205	c.1089G>A	c.(1087-1089)ACG>ACA	p.T363T		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	363						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		GCTCCTGGAGCGTGTCTGTGG	0.577													T	89655829	T	T	89655829	2	4	83	1	0	0	0	0	0	0	0	1	6276	755	27	1		1	GBP4	1	89655829	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08		89655829	159594792	1	5624											
NBPF9	400818	broad.mit.edu	37	chr1	144825416	144825416	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caggactcactgggtagatgGtattcgactccttcaggtta	11	9	2	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr1:144825416G>T	uc009wig.1	+	19	2218	c.2142G>T	c.(2140-2142)TGG>TGT	p.W714C	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.W639C|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.W515C|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Missense_Mutation_p.W374C	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	714	NBPF 5.					cytoplasm					0						TGGGTAGATGGTATTCGACTC	0.498													T	144825416	T	T	144825416	3	4	83	1	0	0	0	0	1	0	0	0	10199	1270	44	5	2202	5	NBPF9	1	144825416	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	55169587	144825416	104425205	2	5625											
TCHH	7062	broad.mit.edu	37	chr1	152082760	152082760	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggcgccttctcttctccGgttcctctcccagcagctgc	8	19	3	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr1:152082760G>A	uc001ezp.2	-	2	2933	c.2933C>T	c.(2932-2934)CCG>CTG	p.P978L	TCHH_uc009wne.1_Missense_Mutation_p.P978L	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	978	10 X 30 AA tandem repeats.|4-3.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			tctcttctccggttcctctcc	0.134													A	152082760	A	A	152082760	3	1	83	1	0	0	0	0	1	0	0	0	15697	1116	39	2	2902	2	TCHH	1	152082760	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	7257344	152082760	97167861	3	5626											
TOMM20	9804	broad.mit.edu	37	chr1	235291954	235291954	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggggtcacttcgtcttttgCggtcgaagtagatgcagtac	13	8	2	1	rs1130507		TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr1:235291954C>T	uc001hwl.2	-	1	303	c.77G>A	c.(76-78)CGC>CAC	p.R26H	SNORA14B_uc001hwm.1_5'Flank	NM_014765	NP_055580	Q15388	TOM20_HUMAN	translocase of outer mitochondrial membrane 20	26	Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|unfolded protein binding				0	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;6.33e-05)|Epithelial(3;8.26e-05)			TCGTCTTTTGCGGTCGAAGTA	0.597													T	235291954	T	T	235291954	3	4	83	1	0	0	0	0	1	0	0	0	16351	768	27	1	380	1	TOMM20	1	235291954	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	83209194	235291954	13958667	4	5627											
OR2M5	127059	broad.mit.edu	37	chr1	248308935	248308935	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcaatcattgatgctgtagcGacattttccttctcctactg	7	11	2	1	rs138472974	byFrequency	TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr1:248308935G>A	uc010pze.1	+	1	486	c.486G>A	c.(484-486)GCG>GCA	p.A162A		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ATGCTGTAGCGACATTTTCCT	0.448													A	248308935	A	A	248308935	2	1	83	1	0	0	0	0	0	0	0	1	11013	1045	37	2		2	OR2M5	1	248308935	Silent	SNP	G	TCGA-06-2567-01A-01D-1494-08	13016981	248308935	941686	5	5628											
OR2M3	127062	broad.mit.edu	37	chr1	248367072	248367072	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgggatctggagagggtcgtCgcaaagcttttactacttgt	13	7	1	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr1:248367072C>T	uc010pzg.1	+	1	703	c.703C>T	c.(703-705)CGC>TGC	p.R235C		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGAGGGTCGTCGCAAAGCTTT	0.473													T	248367072	T	T	248367072	3	4	83	1	0	0	0	0	1	0	0	0	11011	884	31	2	705	2	OR2M3	1	248367072	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	58137	248367072	883549	6	5629											
PROC	5624	broad.mit.edu	37	chr2	128177527	128177527	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgcctccagaatgtggcaGctcacaagcctcctgctgtt	10	13	1	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr2:128177527G>A	uc002tok.2	+	2	82	c.9G>A	c.(7-9)CAG>CAA	p.Q3Q	PROC_uc002tol.2_Silent_p.Q24Q|PROC_uc010yzi.1_Silent_p.Q24Q|PROC_uc010yzj.1_5'UTR|PROC_uc010yzk.1_Silent_p.Q24Q|PROC_uc002tom.2_Silent_p.Q3Q	NM_000312	NP_000303	P04070	PROC_HUMAN	protein C	3					blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	GAATGTGGCAGCTCACAAGCC	0.652													A	128177527	A	A	128177527	2	1	83	1	0	0	0	0	0	0	0	1	12545	962	34	3		3	PROC	2	128177527	Silent	SNP	G	TCGA-06-2567-01A-01D-1494-08		128177527	115021846	7	5630											
SPEG	10290	broad.mit.edu	37	chr2	220349266	220349266	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcgcgctcggaggagcgcGgccccttccgtggggccgag	18	14	0	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr2:220349266G>A	uc010fwg.2	+	30	7081	c.7081G>A	c.(7081-7083)GGC>AGC	p.G2361S		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2361	Arg-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GGAGGAGCGCGGCCCCTTCCG	0.731													A	220349266	A	A	220349266	3	1	83	1	0	0	0	0	1	0	0	0	15035	1116	39	2	7211	2	SPEG	2	220349266	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	92171739	220349266	22850107	8	5631											
IQCA1	79781	broad.mit.edu	37	chr2	237374203	237374203	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggttctccttgatatccaCgccttctatcaactttaggt	6	11	3	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr2:237374203C>T	uc002vvz.1	-	6	1053	c.871G>A	c.(871-873)GTG>ATG	p.V291M	IQCA1_uc002vwb.2_Missense_Mutation_p.V298M|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Missense_Mutation_p.V291M	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	291							ATP binding			ovary(1)	1						TTGATATCCACGCCTTCTATC	0.473													T	237374203	T	T	237374203	3	4	83	1	0	0	0	0	1	0	0	0	7802	536	19	1	1653	1	IQCA1	2	237374203	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	17024937	237374203	5825170	9	5632											
CSPG5	10675	broad.mit.edu	37	chr3	47619240	47619240	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggtgccggtcaccgcagcCgactcctgcagcacctcttc	11	18	2	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr3:47619240C>T	uc003crp.3	-	2	452	c.276G>A	c.(274-276)TCG>TCA	p.S92S	CSPG5_uc003crn.2_5'UTR|CSPG5_uc003cro.3_Silent_p.S92S|CSPG5_uc011bbb.1_5'UTR	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	92	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCACCGCAGCCGACTCCTGCA	0.726													T	47619240	T	T	47619240	2	4	83	1	0	0	0	0	0	0	0	1	3961	639	23	2		2	CSPG5	3	47619240	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08		47619240	150403190	10	5633											
OR5K1	26339	broad.mit.edu	37	chr3	98188663	98188663	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgctattacccccaaaatGttagagaacttcttttctga	6	9	2	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr3:98188663G>A	uc003dsm.2	+	1	243	c.243G>A	c.(241-243)ATG>ATA	p.M81I		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						CCCCCAAAATGTTAGAGAACT	0.413													A	98188663	A	A	98188663	3	1	83	1	0	0	0	0	1	0	0	0	11166	1377	48	3	245	3	OR5K1	3	98188663	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	50569423	98188663	99833767	11	5634											
SLC15A2	6565	broad.mit.edu	37	chr3	121647354	121647354	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaggtgaaggtgacagtggtGggaaatgaaaacaattctct	14	4	1	3			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr3:121647354G>T	uc003eep.2	+	15	1446	c.1293G>T	c.(1291-1293)GTG>GTT	p.V431V	SLC15A2_uc011bjn.1_Silent_p.V400V	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	431					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TGACAGTGGTGGGAAATGAAA	0.443													T	121647354	T	T	121647354	2	4	83	1	0	0	0	0	0	0	0	1	14399	1335	47	5		5	SLC15A2	3	121647354	Silent	SNP	G	TCGA-06-2567-01A-01D-1494-08	23458691	121647354	76375076	12	5635											
COPB2	9276	broad.mit.edu	37	chr3	139098010	139098010	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaacactctaatctgcatGtcatcctagaaacagaaatt	5	9	3	3			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr3:139098010G>A	uc003etf.3	-	4	364	c.234C>T	c.(232-234)GAC>GAT	p.D78D	COPB2_uc011bmv.1_Silent_p.D49D|COPB2_uc010hui.2_Silent_p.D49D|COPB2_uc011bmw.1_Silent_p.D78D	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	78	WD 2.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						TAATCTGCATGTCATCCTAGA	0.363													A	139098010	A	A	139098010	2	1	83	1	0	0	0	0	0	0	0	1	3729	1368	48	3		3	COPB2	3	139098010	Silent	SNP	G	TCGA-06-2567-01A-01D-1494-08	17450656	139098010	58924420	13	5636											
BST1	683	broad.mit.edu	37	chr4	15717416	15717416	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tatgcatgaaattgggggacCcaatgtgtaagttatggtga	13	4	0	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr4:15717416C>G	uc003goh.3	+	6	893	c.698C>G	c.(697-699)CCC>CGC	p.P233R	BST1_uc003goi.2_Missense_Mutation_p.P44R	NM_004334	NP_004325	Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1 precursor	233					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)	1						ATTGGGGGACCCAATGTGTAA	0.328													G	15717416	G	G	15717416	3	3	83	1	0	0	0	0	1	0	0	0	1533	623	22	5	720	5	BST1	4	15717416	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08		15717416	175436860	14	5637											
AREG	374	broad.mit.edu	37	chr4	75312298	75312298	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgacacctactctgggaagCgtgaaccattttctggggac	11	10	2	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr4:75312298C>T	uc011cbl.1	+	2	319	c.109C>T	c.(109-111)CGT>TGT	p.R37C		NM_001657	NP_001648	P15514	AREG_HUMAN	amphiregulin preproprotein	37					cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity				0			Lung(101;0.196)			CTCTGGGAAGCGTGAACCATT	0.483													T	75312298	T	T	75312298	3	4	83	1	0	0	0	0	1	0	0	0	843	768	27	1	115	1	AREG	4	75312298	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	59594882	75312298	115841978	15	5638											
ADH6	130	broad.mit.edu	37	chr4	100130080	100130080	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acagcacaggtagaacctggAgtcacctaaacacatacagg	9	11	1	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr4:100130080A>G	uc003hup.3	-	6	667	c.573T>C	c.(571-573)ACT>ACC	p.T191T	uc003hum.1_Intron|ADH6_uc003huo.2_Silent_p.T191T|ADH6_uc011cef.1_5'UTR|ADH6_uc010ile.2_Silent_p.T191T	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	191					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TAGAACCTGGAGTCACCTAAA	0.458													G	100130080	G	G	100130080	2	3	83	1	0	0	0	0	0	0	0	1	312	291	11	4		4	ADH6	4	100130080	Silent	SNP	A	TCGA-06-2567-01A-01D-1494-08	24817782	100130080	91024196	16	5639											
ITGA1	3672	broad.mit.edu	37	chr5	52183784	52183784	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaagatgaaaacattcaacGgttttccatagctgtaagtg	9	6	1	3			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr5:52183784G>A	uc003jou.2	+	8	963	c.911G>A	c.(910-912)CGG>CAG	p.R304Q	ITGA1_uc003jov.2_RNA	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	304	Extracellular (Potential).|VWFA.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				AACATTCAACGGTTTTCCATA	0.388													A	52183784	A	A	52183784	3	1	83	1	0	0	0	0	1	0	0	0	7872	1116	39	2	941	2	ITGA1	5	52183784	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08		52183784	128731476	17	5640											
DSP	1832	broad.mit.edu	37	chr6	7569486	7569486	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgcagcaagtggtacgtgaCgggcccgggaggcgttgaca	18	10	0	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr6:7569486C>T	uc003mxp.1	+	12	1766	c.1487C>T	c.(1486-1488)ACG>ATG	p.T496M	DSP_uc003mxq.1_Missense_Mutation_p.T496M	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	496	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGGTACGTGACGGGCCCGGGA	0.552													T	7569486	T	T	7569486	3	4	83	1	0	0	0	0	1	0	0	0	4781	536	19	1	1533	1	DSP	6	7569486	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08		7569486	163545581	18	5641											
COL11A2	1302	broad.mit.edu	37	chr6	33153497	33153497	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgataatcaggggttgtcCccgtagtcatcacatcataa	8	11	4	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr6:33153497C>T	uc003ocx.1	-	6	1085	c.857G>A	c.(856-858)GGG>GAG	p.G286E	COL11A2_uc003ocy.1_Intron|COL11A2_uc003ocz.1_Intron	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	286	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						AGGGGTTGTCCCCGTAGTCAT	0.493													T	33153497	T	T	33153497	3	4	83	1	0	0	0	0	1	0	0	0	3668	623	22	3	4597	3	COL11A2	6	33153497	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	25584011	33153497	137961570	19	5642											
ASCC3	10973	broad.mit.edu	37	chr6	101054729	101054729	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggctaatgtgcttgtagcaAtaagaacctaaaaagcaaaa	8	6	0	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr6:101054729A>G	uc003pqk.2	-	32	5260	c.4931T>C	c.(4930-4932)ATT>ACT	p.I1644T		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1644	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GCTTGTAGCAATAAGAACCTA	0.294													G	101054729	G	G	101054729	3	3	83	1	0	0	0	0	1	0	0	0	1033	101	4	4	1721	4	ASCC3	6	101054729	Missense_Mutation	SNP	A	TCGA-06-2567-01A-01D-1494-08	67901232	101054729	70060338	20	5643											
CITED2	10370	broad.mit.edu	37	chr6	139694947	139694947	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attagggcgttgaaggcgtgCtggggctgctgctgctggtg	19	7	0	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr6:139694947C>T	uc003qip.1	-	2	379	c.135G>A	c.(133-135)CAG>CAA	p.Q45Q		NM_006079	NP_006070	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with	45	His-rich.				adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity				0	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		TGAAGGCGTGCTGGGGCTGCT	0.662													T	139694947	T	T	139694947	2	4	83	1	0	0	0	0	0	0	0	1	3440	796	28	3		3	CITED2	6	139694947	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08	38640218	139694947	31420120	21	5644											
HOXA6	3203	broad.mit.edu	37	chr7	27185382	27185382	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cggttctggaaccagatcttGatctggcgctcggtgaggca	14	10	3	3			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr7:27185382G>C	uc003syo.1	-	2	597	c.597C>G	c.(595-597)ATC>ATG	p.I199M	HOXA5_uc003syn.1_5'Flank|uc003syp.1_5'Flank	NM_024014	NP_076919	P31267	HXA6_HUMAN	homeobox A6	199	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						ACCAGATCTTGATCTGGCGCT	0.597													C	27185382	C	C	27185382	3	2	83	1	0	0	0	0	1	0	0	0	7296	1280	45	5	108	5	HOXA6	7	27185382	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08		27185382	131953281	22	5645											
TXNDC3	51314	broad.mit.edu	37	chr7	37934142	37934142	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatgttcctaactcctgagCaaatagagaaaatttatcca	5	8	0	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr7:37934142C>T	uc003tfn.2	+	16	1846	c.1474C>T	c.(1474-1476)CAA>TAA	p.Q492*		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	492	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						AACTCCTGAGCAAATAGAGAA	0.303									Kartagener_syndrome				T	37934142	T	T	37934142	4	4	83	1	0	0	0	0	0	1	0	0	16795	711	25	3	1528	3	TXNDC3	7	37934142	Nonsense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	10748760	37934142	121204521	23	5646											
COBL	23242	broad.mit.edu	37	chr7	51096735	51096735	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggcctcgttggtgccatgaTgttggtgccaaggcagcgtt	15	9	0	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr7:51096735T>C	uc003tpr.3	-	10	2243	c.2058A>G	c.(2056-2058)ACA>ACG	p.T686T	COBL_uc003tps.2_Silent_p.T743T|COBL_uc011kcl.1_Silent_p.T686T|COBL_uc003tpp.3_Silent_p.T472T|COBL_uc003tpq.3_Silent_p.T627T|COBL_uc003tpo.3_Silent_p.T228T	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	686										skin(3)|ovary(2)	5	Glioma(55;0.08)					GGTGCCATGATGTTGGTGCCA	0.498													C	51096735	C	C	51096735	2	2	83	1	0	0	0	0	0	0	0	1	3653	1451	51	4		4	COBL	7	51096735	Silent	SNP	T	TCGA-06-2567-01A-01D-1494-08	13162593	51096735	108041928	24	5647											
POM121L12	285877	broad.mit.edu	37	chr7	53104084	53104084	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gggcctctgaagccgagcctCggcccctggagcctcagttt	13	15	2	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr7:53104084C>T	uc003tpz.2	+	1	736	c.720C>T	c.(718-720)CTC>CTT	p.L240L		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	240											0						AGCCGAGCCTCGGCCCCTGGA	0.647													T	53104084	T	T	53104084	2	4	83	1	0	0	0	0	0	0	0	1	12241	871	31	2		2	POM121L12	7	53104084	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08	2007349	53104084	106034579	25	5648											
EGFR	1956	broad.mit.edu	37	chr7	55233036	55233036	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccactgcgtcaagacctgcCcggcaggagtcatgggagaa	13	13	2	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr7:55233036C>T	uc003tqk.2	+	15	2032	c.1786C>T	c.(1786-1788)CCG>TCG	p.P596S	EGFR_uc003tqi.2_Missense_Mutation_p.P596S|EGFR_uc003tqj.2_Missense_Mutation_p.P596S|EGFR_uc010kzg.1_Missense_Mutation_p.P551S|EGFR_uc011kco.1_Missense_Mutation_p.P543S|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	596	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.P596L(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAAGACCTGCCCGGCAGGAGT	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233036	T	T	55233036	3	4	83	1	0	0	0	0	1	0	0	0	4967	623	22	3	1855	3	EGFR	7	55233036	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	2128952	55233036	103905627	26	5649											
CALN1	83698	broad.mit.edu	37	chr7	71571150	71571150	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttaccgtccatgtccaagCgctgcatgatgatggccagc	10	13	1	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr7:71571150C>T	uc003twa.3	-	3	775	c.248G>A	c.(247-249)CGC>CAC	p.R83H	CALN1_uc003twb.3_Missense_Mutation_p.R125H|CALN1_uc003twc.3_Missense_Mutation_p.R83H	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	83	EF-hand 2.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CATGTCCAAGCGCTGCATGAT	0.587													T	71571150	T	T	71571150	3	4	83	1	0	0	0	0	1	0	0	0	2591	768	27	1	427	1	CALN1	7	71571150	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	16338114	71571150	87567513	27	5650											
SLC26A5	375611	broad.mit.edu	37	chr7	103050930	103050930	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cacagctgctgcggtggtaaAcccacggaccagaggctctg	13	13	1	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr7:103050930A>T	uc003vbz.2	-	7	873	c.637T>A	c.(637-639)TTT>ATT	p.F213I	SLC26A5_uc003vbt.1_Missense_Mutation_p.F213I|SLC26A5_uc003vbu.1_Missense_Mutation_p.F213I|SLC26A5_uc003vbv.1_Missense_Mutation_p.F213I|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.F213I|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	213	Helical; Name=5; (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						GCGGTGGTAAACCCACGGACC	0.408													T	103050930	T	T	103050930	3	4	83	1	0	0	0	0	1	0	0	0	14520	43	2	5	1694	5	SLC26A5	7	103050930	Missense_Mutation	SNP	A	TCGA-06-2567-01A-01D-1494-08	31479780	103050930	56087733	28	5651											
COPG2	26958	broad.mit.edu	37	chr7	130297070	130297070	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agcttcttgggcttcattgaTccagcgcttaaccacatcat	7	12	3	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr7:130297070T>C	uc003vqh.1	-	8	622	c.532A>G	c.(532-534)ATC>GTC	p.I178V		NM_012133	NP_036265	Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2	178					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)					GCTTCATTGATCCAGCGCTTA	0.353													C	130297070	C	C	130297070	3	2	83	1	0	0	0	0	1	0	0	0	3732	1435	50	4	698	4	COPG2	7	130297070	Missense_Mutation	SNP	T	TCGA-06-2567-01A-01D-1494-08	27246140	130297070	28841593	29	5652											
SH2D4A	63898	broad.mit.edu	37	chr8	19177081	19177081	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgaaacagatactgtcggAgatgtacatagatcctgatc	10	8	0	5			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr8:19177081A>G	uc003wzb.2	+	2	359	c.23A>G	c.(22-24)GAG>GGG	p.E8G	SH2D4A_uc011kym.1_Intron|SH2D4A_uc003wzc.2_Missense_Mutation_p.E8G	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	8						cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)		ATACTGTCGGAGATGTACATA	0.463													G	19177081	G	G	19177081	3	3	83	1	0	0	0	0	1	0	0	0	14235	304	11	4	75	4	SH2D4A	8	19177081	Missense_Mutation	SNP	A	TCGA-06-2567-01A-01D-1494-08		19177081	127186941	30	5653											
PREX2	80243	broad.mit.edu	37	chr8	69030839	69030839	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttcaccagcatctgcagcagCcagtgcagctcgtatttcca	8	14	2	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr8:69030839C>A	uc003xxv.1	+	27	3408	c.3381C>A	c.(3379-3381)AGC>AGA	p.S1127R		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1127					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TCTGCAGCAGCCAGTGCAGCT	0.463													A	69030839	A	A	69030839	3	1	83	1	0	0	0	0	1	0	0	0	12477	738	26	5	3716	5	PREX2	8	69030839	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	49853758	69030839	77333183	31	5654											
CSMD3	114788	broad.mit.edu	37	chr8	113529374	113529374	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtcacattgaaaaacaacagTgtccccaggttctcttccat	6	12	2	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr8:113529374T>A	uc003ynu.2	-	28	4804	c.4645A>T	c.(4645-4647)ACT>TCT	p.T1549S	CSMD3_uc003yns.2_Missense_Mutation_p.T821S|CSMD3_uc003ynt.2_Missense_Mutation_p.T1509S|CSMD3_uc011lhx.1_Missense_Mutation_p.T1445S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1549	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAAACAACAGTGTCCCCAGGT	0.498										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			A	113529374	A	A	113529374	3	1	83	1	0	0	0	0	1	0	0	0	3946	1696	59	5	6654	5	CSMD3	8	113529374	Missense_Mutation	SNP	T	TCGA-06-2567-01A-01D-1494-08	44498535	113529374	32834648	32	5655											
SAMD12	401474	broad.mit.edu	37	chr8	119391929	119391929	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttttgtcagtaagtctcagCagggctcgccctgcagggtt	12	10	2	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr8:119391929C>T	uc003yom.2	-	4	462	c.333G>A	c.(331-333)CTG>CTA	p.L111L	SAMD12_uc010mda.1_Silent_p.L111L|SAMD12_uc010mdb.1_RNA	NM_207506	NP_997389	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12 isoform	111	SAM.									ovary(1)	1	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)			TAAGTCTCAGCAGGGCTCGCC	0.488													T	119391929	T	T	119391929	2	4	83	1	0	0	0	0	0	0	0	1	13817	697	25	3		3	SAMD12	8	119391929	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08	5862555	119391929	26972093	33	5656											
COL22A1	169044	broad.mit.edu	37	chr8	139791753	139791753	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctcacagcaacactcaccCgcatgccgacctcacccggc	7	20	3	0	rs149163176	byFrequency	TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr8:139791753C>T	uc003yvd.2	-	14	2150	c.1703G>A	c.(1702-1704)CGG>CAG	p.R568Q		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	568	Pro-rich.|Gly-rich.|Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AACACTCACCCGCATGCCGAC	0.592										HNSCC(7;0.00092)			T	139791753	T	T	139791753	3	4	83	1	0	0	0	0	1	0	0	0	3681	666	23	2	3385	2	COL22A1	8	139791753	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	20399824	139791753	6572269	34	5657											
DMRT1	1761	broad.mit.edu	37	chr9	842164	842164	+	Frame_Shift_Del	DEL	C	-	-													caagaagtgcaacctgatcgCcgagaggcagcgcgtgatgg							TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr9:842164delC	uc003zgv.2	+	1	475	c.326delC	c.(325-327)GCCfs	p.A109fs	DMRT1_uc003zgu.1_Frame_Shift_Del_p.A109fs	NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	109	DM.				cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		AACCTGATCGCCGAGAGGCAG	0.567													-	842164	-	-	842164	7	5	83	1	0	1	0	1	0	0	0	0	4585	739	26	0	328	0	DMRT1	9	842164	Frame_Shift_Del	DEL	C	TCGA-06-2567-01A-01D-1494-08		842164	140371267	35	5658											
CNTNAP3	79937	broad.mit.edu	37	chr9	39078395	39078396	+	Frame_Shift_Del	DEL	AG	-	-													ttgttacctccgatgacagcAgagtctcttctgtctgcatt							TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr9:39078395_39078396delAG	uc004abi.2	-	23	3970_3971	c.3731_3732delCT	c.(3730-3732)TCTfs	p.S1244fs	CNTNAP3_uc004abj.2_Frame_Shift_Del_p.S1163fs|CNTNAP3_uc011lqr.1_RNA	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	1244	Extracellular (Potential).				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CGATGACAGCAGAGTCTCTTCT	0.416													-	39078396	-	-	39078395	7	5	83	1	0	1	0	1	0	0	0	0	3648	175	7	0	142	0	CNTNAP3	9	39078395	Frame_Shift_Del	DEL	AG	TCGA-06-2567-01A-01D-1494-08	38236231	39078395	102135036	36	5659											
OR1N1	138883	broad.mit.edu	37	chr9	125289116	125289116	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacgtgtgagtcagggcaaCgatattggtgaggacccagc	15	8	1	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr9:125289116C>T	uc004bmn.1	-	1	457	c.457G>A	c.(457-459)GTT>ATT	p.V153I		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						GTCAGGGCAACGATATTGGTG	0.537													T	125289116	T	T	125289116	3	4	83	1	0	0	0	0	1	0	0	0	10969	536	19	1	482	1	OR1N1	9	125289116	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	86210721	125289116	15924315	37	5660											
DBH	1621	broad.mit.edu	37	chr9	136508597	136508597	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacatggaagtcttccagtgCgcccccgagatggacagcgt	12	13	1	1	rs141816448		TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr9:136508597C>T	uc004cel.2	+	4	816	c.807C>T	c.(805-807)TGC>TGT	p.C269C		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	269	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	TCTTCCAGTGCGCCCCCGAGA	0.662													T	136508597	T	T	136508597	2	4	83	1	0	0	0	0	0	0	0	1	4250	776	27	1		1	DBH	9	136508597	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08	11219481	136508597	4704834	38	5661											
DLG5	9231	broad.mit.edu	37	chr10	79581860	79581860	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaggagctctgagggaatacCtaggcagggattgcagagga	17	6	1	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr10:79581860C>G	uc001jzk.2	-	15	2453	c.2383_splice	c.e15-1	p.V795_splice	DLG5_uc001jzi.2_5'Flank|DLG5_uc001jzj.2_Intron|DLG5_uc009xru.1_Splice_Site|DLG5_uc001jzl.3_Splice_Site_p.V399_splice	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5						cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GAGGGAATACCTAGGCAGGGA	0.512													G	79581860	G	G	79581860	5	3	83	1	0	0	0	0	0	0	1	0	4558	695	24	5	3449	5	DLG5	10	79581860	Splice_Site	SNP	C	TCGA-06-2567-01A-01D-1494-08		79581860	55952887	39	5662											
HSPA12A	259217	broad.mit.edu	37	chr10	118464692	118464692	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatgcattccggctccttgGtgaagctgtaggcatagcca	13	10	0	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr10:118464692G>A	uc001lct.2	-	3	329	c.224C>T	c.(223-225)ACC>ATC	p.T75I	HSPA12A_uc001lcu.2_5'UTR	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	75							ATP binding			ovary(1)	1				all cancers(201;0.0158)		CGGCTCCTTGGTGAAGCTGTA	0.582													A	118464692	A	A	118464692	3	1	83	1	0	0	0	0	1	0	0	0	7404	1261	44	3	1843	3	HSPA12A	10	118464692	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	38882832	118464692	17070055	40	5663											
DNHD1	144132	broad.mit.edu	37	chr11	6589084	6589084	+	Nonsense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagaaactggctgccaagtaTcagcaggtttgaacctagtt	10	9	1	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr11:6589084T>G	uc001mdw.3	+	36	12909	c.12345T>G	c.(12343-12345)TAT>TAG	p.Y4115*	DNHD1_uc001mea.3_Nonsense_Mutation_p.Y384*|DNHD1_uc001meb.2_Nonsense_Mutation_p.Y383*|DNHD1_uc001mec.2_Nonsense_Mutation_p.Y383*|DNHD1_uc010rao.1_Nonsense_Mutation_p.Y373*|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4115					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CTGCCAAGTATCAGCAGGTTT	0.562													G	6589084	G	G	6589084	4	3	83	1	0	0	0	0	0	1	0	0	4668	1442	50	5	12488	5	DNHD1	11	6589084	Nonsense_Mutation	SNP	T	TCGA-06-2567-01A-01D-1494-08		6589084	128417432	41	5664											
OR5M1	390168	broad.mit.edu	37	chr11	56380101	56380101	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaggattacatctgtgttcCgtaggctatagatcaatggg	11	7	2	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr11:56380101C>T	uc001nja.1	-	1	878	c.878G>A	c.(877-879)CGG>CAG	p.R293Q		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						ATCTGTGTTCCGTAGGCTATA	0.398													T	56380101	T	T	56380101	3	4	83	1	0	0	0	0	1	0	0	0	11172	652	23	2	73	2	OR5M1	11	56380101	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	49791017	56380101	78626415	42	5665											
OR5AR1	219493	broad.mit.edu	37	chr11	56431862	56431862	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgcgttcagctgaaggccGccttaaggctttctccacct	9	13	2	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr11:56431862G>A	uc010rjm.1	+	1	701	c.701G>A	c.(700-702)CGC>CAC	p.R234H		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTGAAGGCCGCCTTAAGGCT	0.483													A	56431862	A	A	56431862	3	1	83	1	0	0	0	0	1	0	0	0	11145	1087	38	1	703	1	OR5AR1	11	56431862	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	51761	56431862	78574654	43	5666											
SORL1	6653	broad.mit.edu	37	chr11	121444999	121444999	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttcgttgccaggagtctggGacttgtatcccactgtccta	10	11	1	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr11:121444999G>A	uc001pxx.2	+	24	3467	c.3387G>A	c.(3385-3387)GGG>GGA	p.G1129G	SORL1_uc010rzp.1_5'Flank	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1129	Extracellular (Potential).|LDL-receptor class A 2.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AGGAGTCTGGGACTTGTATCC	0.453													A	121444999	A	A	121444999	2	1	83	1	0	0	0	0	0	0	0	1	14934	1161	41	3		3	SORL1	11	121444999	Silent	SNP	G	TCGA-06-2567-01A-01D-1494-08	65013137	121444999	13561517	44	5667											
PIP4K2C	79837	broad.mit.edu	37	chr12	57988971	57988971	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggtcttcaggaacctccGtgatcgatttggcattgatg	11	10	2	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr12:57988971G>A	uc001sou.2	+	3	466	c.335G>A	c.(334-336)CGT>CAT	p.R112H	PIP4K2C_uc001sot.2_Missense_Mutation_p.R112H|PIP4K2C_uc010srs.1_Missense_Mutation_p.R94H|PIP4K2C_uc010srt.1_Missense_Mutation_p.R112H	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	112	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					AGGAACCTCCGTGATCGATTT	0.438													A	57988971	A	A	57988971	3	1	83	1	0	0	0	0	1	0	0	0	11938	1145	40	1	345	1	PIP4K2C	12	57988971	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08		57988971	75862924	45	5668											
KCNC2	3747	broad.mit.edu	37	chr12	75441962	75441962	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccctccatcagaagcacacGtgtaatcacctgtcgtcagt	7	14	3	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr12:75441962G>A	uc001sxg.1	-	4	2295	c.1751C>T	c.(1750-1752)ACG>ATG	p.T584M	KCNC2_uc009zry.2_Missense_Mutation_p.T584M|KCNC2_uc001sxe.2_Missense_Mutation_p.T584M|KCNC2_uc001sxf.2_Intron|KCNC2_uc010stw.1_Intron	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	584	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						AGAAGCACACGTGTAATCACC	0.448													A	75441962	A	A	75441962	3	1	83	1	0	0	0	0	1	0	0	0	8015	1145	40	1	239	1	KCNC2	12	75441962	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	17452991	75441962	58409933	46	5669											
SCYL2	55681	broad.mit.edu	37	chr12	100711649	100711649	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcctgatgagataaagaaCagtgttctacccatggttta	8	9	1	3			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr12:100711649C>T	uc001thn.2	+	10	1391	c.1341C>T	c.(1339-1341)AAC>AAT	p.N447N	SCYL2_uc009ztw.1_Silent_p.N274N|SCYL2_uc001thm.1_Silent_p.N447N	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	447	HEAT.				endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						AGATAAAGAACAGTGTTCTAC	0.333													T	100711649	T	T	100711649	2	4	83	1	0	0	0	0	0	0	0	1	13948	477	17	3		3	SCYL2	12	100711649	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08	25269687	100711649	33140246	47	5670											
KSR2	283455	broad.mit.edu	37	chr12	117977605	117977605	+	Frame_Shift_Del	DEL	G	-	-													cggcgtggcactaggagggaGggggggtgctggcgaggagg							TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr12:117977605delG	uc001two.2	-	10	1574	c.1519delC	c.(1519-1521)CTCfs	p.L507fs		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	536	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTAGGAGGGAGGGGGGGTGCT	0.632													-	117977605	-	-	117977605	7	5	83	1	0	1	0	1	0	0	0	0	8582	1000	35	0	1290	0	KSR2	12	117977605	Frame_Shift_Del	DEL	G	TCGA-06-2567-01A-01D-1494-08	17265956	117977605	15874290	48	5671											
PIWIL1	9271	broad.mit.edu	37	chr12	130841563	130841563	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctggctgttgatctatacgcGaagaaattatgaagcagcca	10	8	1	3			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr12:130841563G>A	uc001uik.2	+	13	1595	c.1505G>A	c.(1504-1506)CGA>CAA	p.R502Q	PIWIL1_uc001uij.1_Missense_Mutation_p.R502Q	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	502					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATCTATACGCGAAGAAATTAT	0.348													A	130841563	A	A	130841563	3	1	83	1	0	0	0	0	1	0	0	0	11957	1058	37	2	1551	2	PIWIL1	12	130841563	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	12863958	130841563	3010332	49	5672											
HEATR4	399671	broad.mit.edu	37	chr14	73974950	73974950	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacagggtaagtagcagtaCcttccagagccaagcactga	10	11	1	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr14:73974950C>T	uc010tub.1	-	9	2091	c.1769G>A	c.(1768-1770)GGT>GAT	p.G590D	HEATR4_uc010tua.1_Missense_Mutation_p.G543D	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		AGTAGCAGTACCTTCCAGAGC	0.478													T	73974950	T	T	73974950	3	4	83	1	0	0	0	0	1	0	0	0	7030	507	18	3	1351	3	HEATR4	14	73974950	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08		73974950	33374590	50	5673											
B2M	567	broad.mit.edu	37	chr15	45007798	45007801	+	Frame_Shift_Del	DEL	TCTA	-	-													tttcagcaaggactggtcttTctatctcttgtactacactg							TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr15:45007798_45007801delTCTA	uc001zuc.2	+	2	305_308	c.245_248delTCTA	c.(244-249)TTCTATfs	p.F82fs	B2M_uc010uek.1_Frame_Shift_Del_p.F82fs|B2M_uc010bdx.1_Intron	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	82_83	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GACTGGTCTTTCTATCTCTTGTAC	0.436													-	45007801	-	-	45007798	7	5	83	1	0	1	0	1	0	0	0	0	1244	1783	62	0	251	0	B2M	15	45007798	Frame_Shift_Del	DEL	TCTA	TCGA-06-2567-01A-01D-1494-08		45007798	57523594	51	5674											
C15orf43	145645	broad.mit.edu	37	chr15	45249150	45249150	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ccgacttcttgttcagctgtGatgcctcgcacccagacacg	9	15	2	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr15:45249150G>C	uc001zuk.2	+	2	138	c.121G>C	c.(121-123)GAT>CAT	p.D41H		NM_152448	NP_689661	Q8NHR7	CO043_HUMAN	hypothetical protein LOC145645	41											0		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		GTTCAGCTGTGATGCCTCGCA	0.577													C	45249150	C	C	45249150	3	2	83	1	0	0	0	0	1	0	0	0	1797	1290	45	5	127	5	C15orf43	15	45249150	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	241352	45249150	57282242	52	5675											
CYP11A1	1583	broad.mit.edu	37	chr15	74637444	74637444	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgagtaatttccggagcccGccttcttgatgcgcctgtgc	11	14	1	1	rs121912811		TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr15:74637444G>A	uc002axt.2	-	3	721	c.566C>T	c.(565-567)GCG>GTG	p.A189V	CYP11A1_uc002axs.2_Missense_Mutation_p.A31V|CYP11A1_uc010bjm.1_Missense_Mutation_p.A31V|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Missense_Mutation_p.A189V|CYP11A1_uc010bjp.1_5'Flank|CYP11A1_uc010ulj.1_Intron|CYP11A1_uc010bjq.2_Missense_Mutation_p.A189V	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	189			A -> V (in AICSR; no loss of activity).		C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	TCCGGAGCCCGCCTTCTTGAT	0.587													A	74637444	A	A	74637444	3	1	83	1	0	0	0	0	1	0	0	0	4144	1087	38	1	1027	1	CYP11A1	15	74637444	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	29388294	74637444	27893948	53	5676											
ZNF213	7760	broad.mit.edu	37	chr16	3187509	3187509	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgccgctggctgcggccCgagctgcgtaccaaggagca	15	14	0	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr16:3187509C>T	uc010uws.1	+	2	675	c.228C>T	c.(226-228)CCC>CCT	p.P76P	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_Silent_p.P76P|ZNF213_uc010bth.2_Silent_p.P76P|ZNF213_uc010uwt.1_Silent_p.P76P	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	76	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGCTGCGGCCCGAGCTGCGTA	0.662													T	3187509	T	T	3187509	2	4	83	1	0	0	0	0	0	0	0	1	17766	639	23	2		2	ZNF213	16	3187509	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08		3187509	87167244	54	5677											
CLN3	1201	broad.mit.edu	37	chr16	28489096	28489096	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaggtgttcacgtaggctgCgcctcccaggagcccctcat	12	14	2	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr16:28489096C>T	uc002dpo.2	-	14	1482	c.1159G>A	c.(1159-1161)GCA>ACA	p.A387T	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.A309T|CLN3_uc010vcu.1_Missense_Mutation_p.A287T|CLN3_uc002dpn.2_Missense_Mutation_p.A288T|CLN3_uc002dpm.2_Missense_Mutation_p.A333T|CLN3_uc010vcv.1_Missense_Mutation_p.A363T|CLN3_uc010byd.2_Intron|CLN3_uc002dpp.2_Missense_Mutation_p.A387T|CLN3_uc002dpt.1_Missense_Mutation_p.A287T|CLN3_uc002dpq.1_Missense_Mutation_p.A339T|CLN3_uc010bye.1_Missense_Mutation_p.A370T|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.A260T|CLN3_uc002dpu.1_Missense_Mutation_p.A285T	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	387					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						ACGTAGGCTGCGCCTCCCAGG	0.612													T	28489096	T	T	28489096	3	4	83	1	0	0	0	0	1	0	0	0	3543	768	27	1	165	1	CLN3	16	28489096	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	25301587	28489096	61865657	55	5678											
ORAI3	93129	broad.mit.edu	37	chr16	30960835	30960835	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccttgctctcgggcttcgcCatggtgaggggccgggaggg	19	11	1	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr16:30960835C>T	uc002eac.2	+	1	431	c.225C>T	c.(223-225)GCC>GCT	p.A75A		NM_152288	NP_689501	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator	75	Helical; (Potential).					integral to membrane	protein binding				0						CGGGCTTCGCCATGGTGAGGG	0.692													T	30960835	T	T	30960835	2	4	83	1	0	0	0	0	0	0	0	1	11259	581	21	3		3	ORAI3	16	30960835	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08	2471739	30960835	59393918	56	5679											
CHST5	23563	broad.mit.edu	37	chr16	75563755	75563755	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaggctgaatggctgccgCgtgcacagtgtcttgcatac	13	12	1	1	rs77436937		TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr16:75563755C>T	uc002fei.2	-	3	1923	c.528G>A	c.(526-528)ACG>ACA	p.T176T	CHST5_uc002fej.1_Silent_p.T182T	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	176	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						ATGGCTGCCGCGTGCACAGTG	0.667													T	75563755	T	T	75563755	2	4	83	1	0	0	0	0	0	0	0	1	3407	755	27	1		1	CHST5	16	75563755	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08	44602920	75563755	14790998	57	5680											
TP53	7157	broad.mit.edu	37	chr17	7577127	7577127	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	acaggcacaaacacgcacctCaaagctgttccgtcccagta	7	15	1	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr17:7577127C>T	uc002gim.2	-	8	1005	c.811G>A	c.(811-813)GAG>AAG	p.E271K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E271K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E139K|TP53_uc010cng.1_Missense_Mutation_p.E139K|TP53_uc002gii.1_Missense_Mutation_p.E139K|TP53_uc010cnh.1_Missense_Mutation_p.E271K|TP53_uc010cni.1_Missense_Mutation_p.E271K|TP53_uc002gij.2_Missense_Mutation_p.E271K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	271	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> A (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(22)|p.E271*(14)|p.0?(7)|p.E271V(5)|p.E271Q(3)|p.E271G(3)|p.E271D(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.E271E(2)|p.E271fs*73(1)|p.E258fs*71(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269fs*21(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.E271P(1)|p.E271del(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577127	T	T	7577127	3	4	83	1	0	0	0	0	1	0	0	0	16378	835	29	3	475	3	TP53	17	7577127	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08		7577127	73618083	58	5681											
TP53	7157	broad.mit.edu	37	chr17	7578263	7578263	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgcaaatttccttccactcGgataagatgctgaggagggg	12	9	0	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr17:7578263G>A	uc002gim.2	-	6	780	c.586C>T	c.(586-588)CGA>TGA	p.R196*	TP53_uc002gig.1_Nonsense_Mutation_p.R196*|TP53_uc002gih.2_Nonsense_Mutation_p.R196*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R64*|TP53_uc010cng.1_Nonsense_Mutation_p.R64*|TP53_uc002gii.1_Nonsense_Mutation_p.R64*|TP53_uc010cnh.1_Nonsense_Mutation_p.R196*|TP53_uc010cni.1_Nonsense_Mutation_p.R196*|TP53_uc002gij.2_Nonsense_Mutation_p.R196*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R103*|TP53_uc002gio.2_Nonsense_Mutation_p.R64*|TP53_uc010vug.1_Nonsense_Mutation_p.R157*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(125)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.R196L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R64*(1)|p.I195fs*12(1)|p.R103*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578263	A	A	7578263	4	1	83	1	0	0	0	0	0	1	0	0	16378	1124	39	2	708	2	TP53	17	7578263	Nonsense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	1136	7578263	73616947	59	5682											
MYH13	8735	broad.mit.edu	37	chr17	10206539	10206539	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcagcctgcctcttgtaagActtcactttggcctgcagct	8	14	3	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr17:10206539A>G	uc002gmk.1	-	39	5731	c.5641T>C	c.(5641-5643)TCT>CCT	p.S1881P		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1881	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CTCTTGTAAGACTTCACTTTG	0.612													G	10206539	G	G	10206539	3	3	83	1	0	0	0	0	1	0	0	0	10032	275	10	4	187	4	MYH13	17	10206539	Missense_Mutation	SNP	A	TCGA-06-2567-01A-01D-1494-08	2628276	10206539	70988671	60	5683											
CCDC144A	9720	broad.mit.edu	37	chr17	16593762	16593762	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggaggggctgaggggtctccGaagccggcagtctacgccac	17	12	2	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr17:16593762G>A	uc002gqk.1	+	1	124	c.48G>A	c.(46-48)CCG>CCA	p.P16P		NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	16											0						AGGGGTCTCCGAAGCCGGCAG	0.672													A	16593762	A	A	16593762	2	1	83	1	0	0	0	0	0	0	0	1	2777	1045	37	2		2	CCDC144A	17	16593762	Silent	SNP	G	TCGA-06-2567-01A-01D-1494-08	6387223	16593762	64601448	61	5684											
HELZ	9931	broad.mit.edu	37	chr17	65104714	65104714	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggctgaggaagatgctggaGgtgaggatggtgatggtgtg	21	3	0	4			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr17:65104714G>A	uc010wqk.1	-	30	4808	c.4621C>T	c.(4621-4623)CTC>TTC	p.L1541F	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.L1540F|HELZ_uc010der.2_Missense_Mutation_p.L84F	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGATGCTGGAGGTGAGGATGG	0.577													A	65104714	A	A	65104714	3	1	83	1	0	0	0	0	1	0	0	0	7049	1000	35	3	1226	3	HELZ	17	65104714	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	48510952	65104714	16090496	62	5685											
DSG1	1828	broad.mit.edu	37	chr18	28934952	28934952	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagtaatccaaccaacttcCggcatgataggtagtctgag	10	9	1	3	rs147922509	byFrequency	TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr18:28934952C>T	uc002kwp.2	+	15	3005	c.2793C>T	c.(2791-2793)TCC>TCT	p.S931S	DSG1_uc010xbp.1_Silent_p.S290S	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	931	Desmoglein repeat 5.|Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AACCAACTTCCGGCATGATAG	0.463													T	28934952	T	T	28934952	2	4	83	1	0	0	0	0	0	0	0	1	4776	639	23	2		2	DSG1	18	28934952	Silent	SNP	C	TCGA-06-2567-01A-01D-1494-08		28934952	49142296	63	5686											
STXBP2	6813	broad.mit.edu	37	chr19	7707328	7707328	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccccaggtatgagaccaccGggctgagcgaggcgcgggag	17	12	0	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr19:7707328G>A	uc002mha.3	+	10	853	c.808G>A	c.(808-810)GGG>AGG	p.G270R	STXBP2_uc002mhb.3_Missense_Mutation_p.G267R|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Missense_Mutation_p.G281R|STXBP2_uc010dvk.2_Missense_Mutation_p.G238R|STXBP2_uc002mhc.3_Missense_Mutation_p.G38R|STXBP2_uc002mhe.1_5'Flank	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	270					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						TGAGACCACCGGGCTGAGCGA	0.632													A	7707328	A	A	7707328	3	1	83	1	0	0	0	0	1	0	0	0	15352	1116	39	2	846	2	STXBP2	19	7707328	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08		7707328	51421655	64	5687											
ATG4D	84971	broad.mit.edu	37	chr19	10659590	10659590	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccctccagtgtacaaggcGgatgtggcacgcctggtggc	15	12	0	0			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr19:10659590G>A	uc002mov.2	+	6	966	c.846G>A	c.(844-846)GCG>GCA	p.A282A	ATG4D_uc010xlh.1_Silent_p.A219A|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_Intron	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	282					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			TGTACAAGGCGGATGTGGCAC	0.647													A	10659590	A	A	10659590	2	1	83	1	0	0	0	0	0	0	0	1	1099	1103	39	2		2	ATG4D	19	10659590	Silent	SNP	G	TCGA-06-2567-01A-01D-1494-08	2952262	10659590	48469393	65	5688											
ZNF676	163223	broad.mit.edu	37	chr19	22363176	22363176	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cacattcttcacatttgtagGgtttctctccagcatgaatt	6	10	3	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr19:22363176G>T	uc002nqs.1	-	3	1661	c.1343C>A	c.(1342-1344)CCC>CAC	p.P448H		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ACATTTGTAGGGTTTCTCTCC	0.433													T	22363176	T	T	22363176	3	4	83	1	0	0	0	0	1	0	0	0	18080	1232	43	5	427	5	ZNF676	19	22363176	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	11703586	22363176	36765807	66	5689											
GRIK5	2901	broad.mit.edu	37	chr19	42558502	42558502	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagttcatgaggctggtcccGtggggccaaatgttggccga	15	9	1	1	rs140981334	by1000genomes	TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr19:42558502G>A	uc002osj.1	-	8	1061	c.1026C>T	c.(1024-1026)CAC>CAT	p.H342H	GRIK5_uc010eib.1_Silent_p.H261H	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	342	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GGCTGGTCCCGTGGGGCCAAA	0.652													A	42558502	A	A	42558502	2	1	83	1	0	0	0	0	0	0	0	1	6777	1136	40	1		1	GRIK5	19	42558502	Silent	SNP	G	TCGA-06-2567-01A-01D-1494-08	20195326	42558502	16570481	67	5690											
ZNF28	7576	broad.mit.edu	37	chr19	53303413	53303413	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctttccatgtgtgatttgCgactgaaaactttctcacat	7	9	2	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr19:53303413C>T	uc002qad.2	-	4	1805	c.1685G>A	c.(1684-1686)CGC>CAC	p.R562H	ZNF28_uc002qac.2_Missense_Mutation_p.R509H|ZNF28_uc010eqe.2_Missense_Mutation_p.R508H	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	562	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		GTGTGATTTGCGACTGAAAAC	0.413													T	53303413	T	T	53303413	3	4	83	1	0	0	0	0	1	0	0	0	17810	768	27	1	475	1	ZNF28	19	53303413	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08	10744911	53303413	5825570	68	5691											
CACNG8	59283	broad.mit.edu	37	chr19	54466519	54466519	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgaccatcgccatcagcacTgactactggctctacacgcg	8	15	2	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr19:54466519T>G	uc002qcs.1	+	1	226	c.120T>G	c.(118-120)ACT>ACG	p.T40T		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	41					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CCATCAGCACTGACTACTGGC	0.711													G	54466519	G	G	54466519	2	3	83	1	0	0	0	0	0	0	0	1	2563	1567	55	5		5	CACNG8	19	54466519	Silent	SNP	T	TCGA-06-2567-01A-01D-1494-08	1163106	54466519	4662464	69	5692											
NLRP4	147945	broad.mit.edu	37	chr19	56370584	56370584	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgtttttccgttcaaaatGtctttaagaaagaggatgaa	8	5	3	3			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr19:56370584G>A	uc002qmd.3	+	3	2247	c.1825G>A	c.(1825-1827)GTC>ATC	p.V609I	NLRP4_uc002qmf.2_Missense_Mutation_p.V534I|NLRP4_uc010etf.2_Missense_Mutation_p.V440I	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	609							ATP binding	p.V609F(1)		ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CGTTCAAAATGTCTTTAAGAA	0.408													A	56370584	A	A	56370584	3	1	83	1	0	0	0	0	1	0	0	0	10479	1377	48	3	1831	3	NLRP4	19	56370584	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08	1904065	56370584	2758399	70	5693											
DYNLRB1	83658	broad.mit.edu	37	chr20	33122583	33122583	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	attcgctccaagaaaaatgaAattatggttgcaccaggtaa	8	7	0	2			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr20:33122583A>T	uc002xal.2	+	3	291	c.231A>T	c.(229-231)GAA>GAT	p.E77D	DYNLRB1_uc010zuk.1_Missense_Mutation_p.E77D|DYNLRB1_uc002xam.2_RNA|DYNLRB1_uc002xan.2_RNA	NM_014183	NP_054902	Q9NP97	DLRB1_HUMAN	Roadblock-1	77					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity				0						AGAAAAATGAAATTATGGTTG	0.532													T	33122583	T	T	33122583	3	4	83	1	0	0	0	0	1	0	0	0	4850	11	1	5	241	5	DYNLRB1	20	33122583	Missense_Mutation	SNP	A	TCGA-06-2567-01A-01D-1494-08		33122583	29902937	71	5694											
C21orf91	54149	broad.mit.edu	37	chr21	19169012	19169012	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggccacaatacactgttaCgacataaagtggcacctgaa	9	10	0	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr21:19169012C>T	uc002yko.3	-	3	642	c.551G>A	c.(550-552)CGT>CAT	p.R184H	C21orf91_uc002ykq.3_Missense_Mutation_p.R184H|C21orf91_uc002ykp.3_Missense_Mutation_p.R184H	NM_001100420	NP_001093890	Q9NYK6	EURL_HUMAN	early undifferentiated retina and lens isoform	184										ovary(1)	1				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		TACACTGTTACGACATAAAGT	0.433													T	19169012	T	T	19169012	3	4	83	1	0	0	0	0	1	0	0	0	2134	536	19	1	354	1	C21orf91	21	19169012	Missense_Mutation	SNP	C	TCGA-06-2567-01A-01D-1494-08		19169012	28960883	72	5695											
WDR4	10785	broad.mit.edu	37	chr21	44296865	44296865	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagtcatagatgaagagGctgtcatcatcactaaagag	10	8	4	4			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr21:44296865G>A	uc002zci.2	-	2	175	c.102C>T	c.(100-102)AGC>AGT	p.S34S	WDR4_uc002zck.1_Silent_p.S34S|WDR4_uc002zcl.1_5'UTR|WDR4_uc010gpg.1_Silent_p.S34S|WDR4_uc011aew.1_5'UTR|WDR4_uc010gph.1_5'UTR	NM_033661	NP_387510	P57081	WDR4_HUMAN	WD repeat domain 4 protein	34					tRNA modification	cytoplasm|nucleoplasm	protein binding			ovary(1)	1				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		AGATGAAGAGGCTGTCATCAT	0.303													A	44296865	A	A	44296865	2	1	83	1	0	0	0	0	0	0	0	1	17290	1194	42	3		3	WDR4	21	44296865	Silent	SNP	G	TCGA-06-2567-01A-01D-1494-08	25127853	44296865	3833030	73	5696											
RFPL3	10738	broad.mit.edu	37	chr22	32756314	32756314	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcaggagcgtccgaagtgGgctcatcacacagaatcggc	12	13	3	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chr22:32756314G>A	uc003amj.2	+	2	654	c.449G>A	c.(448-450)GGG>GAG	p.G150E	RFPL3_uc010gwn.2_Missense_Mutation_p.G121E|RFPL3S_uc003amk.2_RNA|RFPL3S_uc003aml.2_RNA	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	150	B30.2/SPRY.						zinc ion binding			ovary(1)	1						GTCCGAAGTGGGCTCATCACA	0.542													A	32756314	A	A	32756314	3	1	83	1	0	0	0	0	1	0	0	0	13255	1232	43	3	455	3	RFPL3	22	32756314	Missense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08		32756314	18548252	74	5697											
WWC3	55841	broad.mit.edu	37	chrX	10096666	10096666	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tggagagggaactggccgagGagcgggccaagctggagtac	19	8	0	1			TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chrX:10096666G>T	uc004csx.3	+	17	2548	c.2350G>T	c.(2350-2352)GAG>TAG	p.E784*	WWC3_uc010nds.2_Nonsense_Mutation_p.E448*|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	784	Potential.									ovary(4)	4						ACTGGCCGAGGAGCGGGCCAA	0.662													T	10096666	T	T	10096666	4	4	83	1	0	0	0	0	0	1	0	0	17410	1175	41	5	2412	5	WWC3	23	10096666	Nonsense_Mutation	SNP	G	TCGA-06-2567-01A-01D-1494-08		10096666	145173894	75	5698											
MSL3	10943	broad.mit.edu	37	chrX	11780954	11780957	+	Splice_Site	DEL	AGTT	-	-													atgtctatgtttttgttaacAgttagtgaaacttccatgcc							TCGA-06-2567-01A-01D-1494-08	TCGA-06-2567-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d40a4861-b8c4-4fb8-815a-4e82801eedca	2017d04a-d545-43f6-973c-e6e40cfdb176	g.chrX:11780954_11780957delAGTT	uc004cuw.2	+	7	694	c.589_splice	c.e7-1	p.L197_splice	MSL3_uc004cuv.1_Splice_Site_p.L197_splice|MSL3_uc004cux.2_Splice_Site_p.L138_splice|MSL3_uc011mig.1_Splice_Site_p.L48_splice|MSL3_uc011mih.1_Splice_Site_p.L185_splice|MSL3_uc004cuy.2_Splice_Site_p.L31_splice|MSL3_uc011mii.1_Splice_Site_p.L31_splice	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a						histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTTTGTTAACAGTTAGTGAAACTT	0.368													-	11780957	-	-	11780954	8	5	83	1	0	1	0	1	0	0	1	0	9879	202	7	0	613	0	MSL3	23	11780954	Splice_Site	DEL	AGTT	TCGA-06-2567-01A-01D-1494-08	1684288	11780954	143489606	76	5699											
GLIS1	148979	broad.mit.edu	37	chr1	54060499	54060499	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggcgaggcttcggcccgggAggtccaggtctgggtgcagg	20	10	1	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr1:54060499A>G	uc001cvr.1	-	3	644	c.77T>C	c.(76-78)CTC>CCC	p.L26P		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	26					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						TCGGCCCGGGAGGTCCAGGTC	0.706													G	54060499	G	G	54060499	3	3	84	1	0	0	0	0	1	0	0	0	6445	304	11	4	1817	4	GLIS1	1	54060499	Missense_Mutation	SNP	A	TCGA-06-2569-01A-01D-1494-08		54060499	195190122	1	5700											
TRIM46	80128	broad.mit.edu	37	chr1	155150608	155150608	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagcggctggcccgtctcaGcgcccagatccaggagcacc	14	16	1	1			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr1:155150608G>A	uc001fhs.1	+	6	1123	c.1040G>A	c.(1039-1041)AGC>AAC	p.S347N	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.S347N|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.S221N|TRIM46_uc001fhu.1_Missense_Mutation_p.S324N|TRIM46_uc009wpg.1_Missense_Mutation_p.S334N|TRIM46_uc001fhv.3_Missense_Mutation_p.S334N|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	347	Potential.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCCCGTCTCAGCGCCCAGATC	0.622													A	155150608	A	A	155150608	3	1	84	1	0	0	0	0	1	0	0	0	16518	971	34	3	1062	3	TRIM46	1	155150608	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08	101090109	155150608	94100013	2	5701											
IGSF8	93185	broad.mit.edu	37	chr1	160063842	160063842	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctgtgtgcttgtcctcgCcaggcagcccagtgccagct	11	15	1	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr1:160063842C>T	uc001fva.2	-	3	607	c.562G>A	c.(562-564)GCG>ACG	p.A188T	IGSF8_uc001fuz.2_Missense_Mutation_p.A188T|IGSF8_uc009wtf.2_Missense_Mutation_p.A188T	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	188	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CTTGTCCTCGCCAGGCAGCCC	0.677													T	160063842	T	T	160063842	3	4	84	1	0	0	0	0	1	0	0	0	7604	739	26	3	1295	3	IGSF8	1	160063842	Missense_Mutation	SNP	C	TCGA-06-2569-01A-01D-1494-08	4913234	160063842	89186779	3	5702											
OBSCN	84033	broad.mit.edu	37	chr1	228511139	228511139	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccagtgtgcgctggttcaagGatgggaagttgttggaggag	18	5	1	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr1:228511139G>A	uc009xez.1	+	56	15528	c.15484G>A	c.(15484-15486)GAT>AAT	p.D5162N	OBSCN_uc001hsn.2_Missense_Mutation_p.D5162N	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5162	Ig-like 49.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTGGTTCAAGGATGGGAAGTT	0.537													A	228511139	A	A	228511139	3	1	84	1	0	0	0	0	1	0	0	0	10812	1174	41	3	15702	3	OBSCN	1	228511139	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08	68447297	228511139	20739482	4	5703											
OBSCN	84033	broad.mit.edu	37	chr1	228511261	228511261	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gtctaccgctgcctggccgaGaacagcatgggtgtctcctc	12	14	2	1			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr1:228511261G>A	uc009xez.1	+	56	15650	c.15606G>A	c.(15604-15606)GAG>GAA	p.E5202E	OBSCN_uc001hsn.2_Silent_p.E5202E	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5202	Ig-like 49.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCCTGGCCGAGAACAGCATGG	0.577													A	228511261	A	A	228511261	2	1	84	1	0	0	0	0	0	0	0	1	10812	933	33	3		3	OBSCN	1	228511261	Silent	SNP	G	TCGA-06-2569-01A-01D-1494-08	122	228511261	20739360	5	5704											
HOXD8	3234	broad.mit.edu	37	chr2	176996300	176996301	+	Frame_Shift_Del	DEL	AA	-	-													ggaaacgaaaaaggaagcccAagagctggaggaagacagag							TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr2:176996300_176996301delAA	uc002uko.2	+	2	1451_1452	c.833_834delAA	c.(832-834)CAAfs	p.Q278fs	uc002ukm.1_5'Flank|HOXD8_uc002ukn.2_Frame_Shift_Del_p.Q94fs|HOXD8_uc002ukp.2_Frame_Shift_Del_p.Q277fs	NM_019558	NP_062458	P13378	HXD8_HUMAN	homeobox D8	278					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		AAGGAAGCCCAAGAGCTGGAGG	0.426													-	176996301	-	-	176996300	7	5	84	1	0	1	0	1	0	0	0	0	7325	130	5	0	839	0	HOXD8	2	176996300	Frame_Shift_Del	DEL	AA	TCGA-06-2569-01A-01D-1494-08		176996300	66203073	6	5705											
TMPRSS7	344805	broad.mit.edu	37	chr3	111766626	111766626	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttctatgcagagcatctgtcTctccactacccgctggagat	8	13	3	2			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr3:111766626T>G	uc010hqb.2	+	5	563	c.393T>G	c.(391-393)TCT>TCG	p.S131S	TMPRSS7_uc011bhr.1_5'UTR	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	257	Extracellular (Potential).|CUB 1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						AGCATCTGTCTCTCCACTACC	0.448													G	111766626	G	G	111766626	2	3	84	1	0	0	0	0	0	0	0	1	16249	1538	54	5		5	TMPRSS7	3	111766626	Silent	SNP	T	TCGA-06-2569-01A-01D-1494-08		111766626	86255804	7	5706											
MUC20	200958	broad.mit.edu	37	chr3	195456549	195456549	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggtttcctcctcctgcggcTgagtgtggcttccccggaag	13	13	0	1			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr3:195456549T>C	uc010hzo.2	+	4	1613	c.1487T>C	c.(1486-1488)CTG>CCG	p.L496P	MUC20_uc010hzp.2_Missense_Mutation_p.L461P	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	667	Interaction with MET.				protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CTCCTGCGGCTGAGTGTGGCT	0.453													C	195456549	C	C	195456549	3	2	84	1	0	0	0	0	1	0	0	0	9976	1580	55	4	1501	4	MUC20	3	195456549	Missense_Mutation	SNP	T	TCGA-06-2569-01A-01D-1494-08	83689923	195456549	2565881	8	5707											
ATP5I	521	broad.mit.edu	37	chr4	666298	666298	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgcagggtcactcactttaaTatgctgtcatcttgggccgg	11	11	4	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr4:666298T>C	uc003gas.2	-	4	287	c.201A>G	c.(199-201)ATA>ATG	p.I67M	ATP5I_uc003gar.2_RNA|MYL5_uc003gat.2_5'Flank|MYL5_uc003gau.2_5'Flank	NM_007100	NP_009031	P56385	ATP5I_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	67					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity				0						CTCACTTTAATATGCTGTCAT	0.448													C	666298	C	C	666298	3	2	84	1	0	0	0	0	1	0	0	0	1157	1396	49	4	12	4	ATP5I	4	666298	Missense_Mutation	SNP	T	TCGA-06-2569-01A-01D-1494-08		666298	190487978	9	5708											
ATP10D	57205	broad.mit.edu	37	chr4	47538903	47538903	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	accctcactgagaataagatGgtttttcgaagatgtagtgt	10	6	1	3			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr4:47538903G>T	uc003gxk.1	+	9	1508	c.1344G>T	c.(1342-1344)ATG>ATT	p.M448I	ATP10D_uc003gxl.1_5'UTR|ATP10D_uc003gxj.3_Missense_Mutation_p.M433I	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	448	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						AGAATAAGATGGTTTTTCGAA	0.433													T	47538903	T	T	47538903	3	4	84	1	0	0	0	0	1	0	0	0	1118	1348	47	5	1374	5	ATP10D	4	47538903	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08	46872605	47538903	143615373	10	5709											
CCDC99	54908	broad.mit.edu	37	chr5	169031191	169031191	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttctaaatctactccagagAcccagtgccctcaacagtaa	5	14	3	1			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr5:169031191A>G	uc003mae.3	+	12	2077	c.1798A>G	c.(1798-1800)ACC>GCC	p.T600A	CCDC99_uc011deq.1_Missense_Mutation_p.T417A|CCDC99_uc010jjk.2_Missense_Mutation_p.T326A	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	600					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TACTCCAGAGACCCAGTGCCC	0.358													G	169031191	G	G	169031191	3	3	84	1	0	0	0	0	1	0	0	0	2876	275	10	4	1840	4	CCDC99	5	169031191	Missense_Mutation	SNP	A	TCGA-06-2569-01A-01D-1494-08		169031191	11884069	11	5710											
COL19A1	1310	broad.mit.edu	37	chr6	70916651	70916651	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgaacctggaattgggctGccagggagtccaggtcttcc	15	10	1	1			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr6:70916651G>A	uc003pfc.1	+	50	3387	c.3270G>A	c.(3268-3270)CTG>CTA	p.L1090L		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	1090	Triple-helical region 6 (COL6).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GAATTGGGCTGCCAGGGAGTC	0.458													A	70916651	A	A	70916651	2	1	84	1	0	0	0	0	0	0	0	1	3676	1306	46	3		3	COL19A1	6	70916651	Silent	SNP	G	TCGA-06-2569-01A-01D-1494-08		70916651	100198416	12	5711											
SDK1	221935	broad.mit.edu	37	chr7	4153059	4153059	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gccagtgagaccagcctgcgGcttcgctgggtggtgagtgg	18	10	0	2			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr7:4153059G>T	uc003smx.2	+	24	3712	c.3573G>T	c.(3571-3573)CGG>CGT	p.R1191R	SDK1_uc010kso.2_Silent_p.R467R	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1191	Fibronectin type-III 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCAGCCTGCGGCTTCGCTGGG	0.637													T	4153059	T	T	4153059	2	4	84	1	0	0	0	0	0	0	0	1	13968	1190	42	5		5	SDK1	7	4153059	Silent	SNP	G	TCGA-06-2569-01A-01D-1494-08		4153059	154985604	13	5712											
LOC402644	402644	broad.mit.edu	37	chr7	28319007	28319007	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acggaacagtttgtgttgggTccagaatttgccatggacaa	12	7	0	1	rs177483	by1000genomes	TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr7:28319007T>A	uc010kuz.1	-	1	312	c.312A>T	c.(310-312)GGA>GGT	p.G104G		NM_001126493	NP_001119965			hypothetical protein LOC402644												0						TTGTGTTGGGTCCAGAATTTG	0.463													A	28319007	A	A	28319007	2	1	84	1	0	0	0	0	0	0	0	1	8878	1654	58	5		5	LOC402644	7	28319007	Silent	SNP	T	TCGA-06-2569-01A-01D-1494-08	24165948	28319007	130819656	14	5713											
KBTBD2	25948	broad.mit.edu	37	chr7	32909138	32909138	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgttcagatatatgctgcCgcagagaccaccggtcaagt	10	12	2	2			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr7:32909138C>T	uc003tdb.2	-	4	2350	c.1691G>A	c.(1690-1692)CGG>CAG	p.R564Q	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	564	Kelch 5.										0			GBM - Glioblastoma multiforme(11;0.0499)			TATATGCTGCCGCAGAGACCA	0.463													T	32909138	T	T	32909138	3	4	84	1	0	0	0	0	1	0	0	0	7993	652	23	2	184	2	KBTBD2	7	32909138	Missense_Mutation	SNP	C	TCGA-06-2569-01A-01D-1494-08	4590131	32909138	126229525	15	5714											
ELN	2006	broad.mit.edu	37	chr7	73474491	73474491	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcagcaaaatccgctgccaAggtggctgccaaagcccagc	11	14	0	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr7:73474491A>G	uc003tzw.2	+	24	1707	c.1616A>G	c.(1615-1617)AAG>AGG	p.K539R	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Missense_Mutation_p.K533R|ELN_uc003tzz.2_Missense_Mutation_p.K452R|ELN_uc003tzo.2_Intron|ELN_uc003tzp.2_Missense_Mutation_p.K444R|ELN_uc003tzq.2_Missense_Mutation_p.K397R|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Missense_Mutation_p.K514R|ELN_uc003tzt.2_Missense_Mutation_p.K538R|ELN_uc003tzu.2_Missense_Mutation_p.K519R|ELN_uc003tzv.2_Missense_Mutation_p.K504R|ELN_uc003tzx.2_Missense_Mutation_p.K523R|ELN_uc011kff.1_Missense_Mutation_p.K533R|ELN_uc003tzy.2_Missense_Mutation_p.K509R	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	562	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding	p.Q539Q(1)		ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TCCGCTGCCAAGGTGGCTGCC	0.637			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						G	73474491	G	G	73474491	3	3	84	1	0	0	0	0	1	0	0	0	5071	72	3	4	1707	4	ELN	7	73474491	Missense_Mutation	SNP	A	TCGA-06-2569-01A-01D-1494-08	40565353	73474491	85664172	16	5715											
TRPV5	56302	broad.mit.edu	37	chr7	142625890	142625890	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cccatgtccatcgtaggacaGcagcaggttgtacatctggc	11	12	1	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr7:142625890G>T	uc003wby.1	-	6	922	c.658C>A	c.(658-660)CTG>ATG	p.L220M	TRPV5_uc003wbz.2_Missense_Mutation_p.L220M	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	220	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					TCGTAGGACAGCAGCAGGTTG	0.572													T	142625890	T	T	142625890	3	4	84	1	0	0	0	0	1	0	0	0	16596	962	34	5	1571	5	TRPV5	7	142625890	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08	69151399	142625890	16512773	17	5716											
WNK2	65268	broad.mit.edu	37	chr9	96030181	96030181	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgccacacctcagcacctgcGgcctgggcaccggggaggtg	15	16	1	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr9:96030181G>T	uc004ati.1	+	16	3850	c.3850G>T	c.(3850-3852)GGC>TGC	p.G1284C	WNK2_uc011lud.1_Missense_Mutation_p.G1284C|WNK2_uc004atj.2_Missense_Mutation_p.G1284C|WNK2_uc004atk.2_Missense_Mutation_p.G921C	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1284					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CAGCACCTGCGGCCTGGGCAC	0.657													T	96030181	T	T	96030181	3	4	84	1	0	0	0	0	1	0	0	0	17375	1116	39	5	3912	5	WNK2	9	96030181	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08		96030181	45183250	18	5717											
ANAPC2	29882	broad.mit.edu	37	chr9	140074735	140074735	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggcggccagaactcactggaCaggatgacagcgtagacccc	13	13	1	3			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr9:140074735C>A	uc004clr.1	-	10	1861	c.1788G>T	c.(1786-1788)CTG>CTT	p.L596L	ANAPC2_uc004clq.1_Silent_p.L452L	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	596					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		ACTCACTGGACAGGATGACAG	0.607													A	140074735	A	A	140074735	2	1	84	1	0	0	0	0	0	0	0	1	603	465	17	5		5	ANAPC2	9	140074735	Silent	SNP	C	TCGA-06-2569-01A-01D-1494-08	44044554	140074735	1138696	19	5718											
LHPP	64077	broad.mit.edu	37	chr10	126172716	126172716	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccctgccgcagactgaagcGttcccggctgaaggtgaggt	14	13	0	4			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr10:126172716G>A	uc001lhs.1	+	2	154	c.134G>A	c.(133-135)CGT>CAT	p.R45H	LHPP_uc001lht.1_Missense_Mutation_p.R45H|LHPP_uc009yai.1_Missense_Mutation_p.R45H	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	45					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		AGACTGAAGCGTTCCCGGCTG	0.617													A	126172716	A	A	126172716	3	1	84	1	0	0	0	0	1	0	0	0	8769	1145	40	1	140	1	LHPP	10	126172716	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08		126172716	9362031	20	5719											
RAG1	5896	broad.mit.edu	37	chr11	36596029	36596029	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttttgtgcacattaataaagGgggccggccccgccaacatc	10	12	0	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr11:36596029G>T	uc001mwu.3	+	2	1299	c.1175G>T	c.(1174-1176)GGG>GTG	p.G392V	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	392	NBD.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				ATTAATAAAGGGGGCCGGCCC	0.478									Familial_Hemophagocytic_Lymphohistiocytosis				T	36596029	T	T	36596029	3	4	84	1	0	0	0	0	1	0	0	0	13003	1232	43	5	1177	5	RAG1	11	36596029	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08		36596029	98410487	21	5720											
MAP6	4135	broad.mit.edu	37	chr11	75316902	75316902	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctctttgctttgctccttgtCgtctggcttggtggtactcg	11	11	2	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr11:75316902C>T	uc001owu.2	-	3	1332	c.1267G>A	c.(1267-1269)GAC>AAC	p.D423N	MAP6_uc001owv.2_Missense_Mutation_p.D423N	NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	423						Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					TGCTCCTTGTCGTCTGGCTTG	0.542													T	75316902	T	T	75316902	3	4	84	1	0	0	0	0	1	0	0	0	9264	884	31	2	1186	2	MAP6	11	75316902	Missense_Mutation	SNP	C	TCGA-06-2569-01A-01D-1494-08	38720873	75316902	59689614	22	5721											
CLEC4C	170482	broad.mit.edu	37	chr12	7882275	7882280	+	In_Frame_Del	DEL	AACGGA	-	-													ccagccccattcttctgaagAacggaaatttattatcgcac							TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr12:7882275_7882280delAACGGA	uc001qtg.1	-	6	728_733	c.554_559delTCCGTT	c.(553-561)TTCCGTTCT>TCT	p.FR185del	CLEC4C_uc001qth.1_In_Frame_Del_p.FR185del|CLEC4C_uc001qti.1_In_Frame_Del_p.FR154del	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	185_186	Extracellular (Potential).|C-type lectin.				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		TCTTCTGAAGAACGGAAATTTATTAT	0.398													-	7882280	-	-	7882275	7	5	84	1	0	1	0	1	0	0	0	0	3513	246	9	0	86	0	CLEC4C	12	7882275	In_Frame_Del	DEL	AACGGA	TCGA-06-2569-01A-01D-1494-08		7882275	125969620	23	5722											
TMBIM4	51643	broad.mit.edu	37	chr12	66547227	66547227	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtagacttttctcagaaaGgctaaaagagaaaaaaaatt	7	5	1	3			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr12:66547227G>A	uc001stc.2	-	2	175	c.99C>T	c.(97-99)GCC>GCT	p.A33A	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Intron|TMBIM4_uc009zqr.2_Silent_p.T80T|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_Silent_p.A33A|TMBIM4_uc009zqs.2_Silent_p.A33A	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	33						integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		TTCTCAGAAAGGCTAAAAGAG	0.289													A	66547227	A	A	66547227	2	1	84	1	0	0	0	0	0	0	0	1	15979	1014	35	3		3	TMBIM4	12	66547227	Silent	SNP	G	TCGA-06-2569-01A-01D-1494-08	58664952	66547227	67304668	24	5723											
WDFY2	115825	broad.mit.edu	37	chr13	52234797	52234797	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagcgtataccatgcaatgcCttgtaagtatccaaatcgct	7	10	0	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr13:52234797C>G	uc001vfp.2	+	2	543	c.203C>G	c.(202-204)CCT>CGT	p.P68R	WDFY2_uc010ads.1_Missense_Mutation_p.P68R|WDFY2_uc010adt.1_RNA	NM_052950	NP_443182	Q96P53	WDFY2_HUMAN	WD repeat and FYVE domain containing 2	68	WD 2.						metal ion binding				0		Breast(56;0.000208)|Lung NSC(96;0.000517)|Prostate(109;0.0041)|Hepatocellular(98;0.0652)|Myeloproliferative disorder(33;0.164)|all_neural(104;0.191)		GBM - Glioblastoma multiforme(99;9e-08)		CATGCAATGCCTTGTAAGTAT	0.403													G	52234797	G	G	52234797	3	3	84	1	0	0	0	0	1	0	0	0	17266	681	24	5	209	5	WDFY2	13	52234797	Missense_Mutation	SNP	C	TCGA-06-2569-01A-01D-1494-08		52234797	62935081	25	5724											
DICER1	23405	broad.mit.edu	37	chr14	95560476	95560476	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aatcgcatctcccaggaattCtaagcgctggtaacaatctg	8	11	3	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr14:95560476C>G	uc001ydw.2	-	25	5295	c.5113G>C	c.(5113-5115)GAA>CAA	p.E1705Q	DICER1_uc010avh.1_Missense_Mutation_p.E603Q|DICER1_uc001ydv.2_Missense_Mutation_p.E1695Q|DICER1_uc001ydx.2_Missense_Mutation_p.E1705Q	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1705	RNase III 2.	Magnesium or manganese 2.			negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CCCAGGAATTCTAAGCGCTGG	0.527			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				G	95560476	G	G	95560476	3	3	84	1	0	0	0	0	1	0	0	0	4521	922	32	5	671	5	DICER1	14	95560476	Missense_Mutation	SNP	C	TCGA-06-2569-01A-01D-1494-08		95560476	11789064	26	5725											
DICER1	23405	broad.mit.edu	37	chr14	95571502	95571519	+	In_Frame_Del	DEL	AAAGTATGCTGGGGAGAC	-	-													caaaaggcagtgaaggcgatAaagtatgctggggagacaaa							TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr14:95571502_95571519delAAAGTATGCTGGGGAGAC	uc001ydw.2	-	21	3340_3357	c.3158_3175delGTCTCCCCAGCATACTTT	c.(3157-3177)TGTCTCCCCAGCATACTTTAT>TAT	p.CLPSIL1053del	DICER1_uc010avh.1_5'UTR|DICER1_uc001ydv.2_In_Frame_Del_p.CLPSIL1043del|DICER1_uc001ydx.2_In_Frame_Del_p.CLPSIL1053del|DICER1_uc001ydy.1_5'Flank	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1053_1058					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TGAAGGCGATAAAGTATGCTGGGGAGACAAACAGCTTT	0.468			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				-	95571519	-	-	95571502	7	5	84	1	0	1	0	1	0	0	0	0	4521	362	13	0	2625	0	DICER1	14	95571502	In_Frame_Del	DEL	AAAGTATGCTGGGGAGAC	TCGA-06-2569-01A-01D-1494-08	11026	95571502	11778038	27	5726											
ITGAD	3681	broad.mit.edu	37	chr16	31422097	31422097	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgtggaagggggtacagaaCctggtcctgggggccccccg	17	12	0	1			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr16:31422097C>A	uc002ebv.1	+	12	1303	c.1254C>A	c.(1252-1254)AAC>AAA	p.N418K	ITGAD_uc010cap.1_Missense_Mutation_p.N418K	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	418	FG-GAP 4.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						GGGTACAGAACCTGGTCCTGG	0.647													A	31422097	A	A	31422097	3	1	84	1	0	0	0	0	1	0	0	0	7884	506	18	5	1300	5	ITGAD	16	31422097	Missense_Mutation	SNP	C	TCGA-06-2569-01A-01D-1494-08		31422097	58932656	28	5727											
TP53	7157	broad.mit.edu	37	chr17	7578456	7578467	+	In_Frame_Del	DEL	GCGGACGCGGGT	-	-													tgcttgtagatggccatggcGcggacgcgggtgccgggcgg					rs139200646		TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr17:7578456_7578467delGCGGACGCGGGT	uc002gim.2	-	5	657_668	c.463_474delACCCGCGTCCGC	c.(463-474)ACCCGCGTCCGCdel	p.TRVR155del	TP53_uc002gig.1_In_Frame_Del_p.TRVR155del|TP53_uc002gih.2_In_Frame_Del_p.TRVR155del|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_In_Frame_Del_p.TRVR23del|TP53_uc010cng.1_In_Frame_Del_p.TRVR23del|TP53_uc002gii.1_In_Frame_Del_p.TRVR23del|TP53_uc010cnh.1_In_Frame_Del_p.TRVR155del|TP53_uc010cni.1_In_Frame_Del_p.TRVR155del|TP53_uc002gij.2_In_Frame_Del_p.TRVR155del|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_In_Frame_Del_p.TRVR62del|TP53_uc002gio.2_In_Frame_Del_p.TRVR23del|TP53_uc010vug.1_In_Frame_Del_p.TRVR116del	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	155_158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(139)|p.R158H(58)|p.R158L(55)|p.R156P(24)|p.T155N(19)|p.R158C(17)|p.T155P(14)|p.T155I(10)|p.V157I(10)|p.R156H(10)|p.R158G(10)|p.R158P(9)|p.V157D(8)|p.R156fs*14(8)|p.T155A(7)|p.V157G(7)|p.0?(7)|p.V157L(6)|p.R158R(6)|p.V157V(5)|p.T155T(5)|p.R158fs*12(5)|p.P152fs*14(4)|p.R158_A159insX(4)|p.V157fs*13(3)|p.R156R(3)|p.R156S(3)|p.R156fs*25(3)|p.R156L(3)|p.R156G(3)|p.T155S(2)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.G154fs*14(2)|p.R158fs*11(2)|p.R156C(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.A159fs*11(1)|p.R65L(1)|p.D148fs*23(1)|p.V157A(1)|p.A159fs*21(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.T155fs*25(1)|p.R156_A161del(1)|p.D148_T155delDSTPPPGT(1)|p.G154_R156delGTR(1)|p.V157_M160delVRAM(1)|p.R156fs*12(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.R158_A159insXX(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156del(1)|p.T155fs*15(1)|p.T155_R156delTR(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*25(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.R158fs*8(1)|p.T155fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGCCATGGCGCGGACGCGGGTGCCGGGCGGG	0.623		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			-	7578467	-	-	7578456	7	5	84	1	0	1	0	1	0	0	0	0	16378	1074	38	0	824	0	TP53	17	7578456	In_Frame_Del	DEL	GCGGACGCGGGT	TCGA-06-2569-01A-01D-1494-08		7578456	73616754	29	5728											
EVI2B	2124	broad.mit.edu	37	chr17	29631684	29631684	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cagcactatcttctgatgtaCcatttacttgatcttttatt	4	9	3	2			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr17:29631684C>G	uc002hgk.2	-	2	1099	c.944G>C	c.(943-945)GGT>GCT	p.G315A	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.G330A	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	315	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TTCTGATGTACCATTTACTTG	0.388													G	29631684	G	G	29631684	3	3	84	1	0	0	0	0	1	0	0	0	5288	507	18	5	406	5	EVI2B	17	29631684	Missense_Mutation	SNP	C	TCGA-06-2569-01A-01D-1494-08	22053228	29631684	51563526	30	5729											
NF1	4763	broad.mit.edu	37	chr17	29653042	29653043	+	Frame_Shift_Ins	INS	-	A	A													tctccgcagtctatatctatINSaactgtaactcctgggtcag							TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr17:29653042_29653043insA	uc002hgg.2	+	37	5373_5374	c.5040_5041insA	c.(5038-5043)TATAACfs	p.Y1680fs	NF1_uc002hgh.2_Frame_Shift_Ins_p.Y1659fs|NF1_uc002hgi.1_Frame_Shift_Ins_p.Y692fs|NF1_uc010cso.2_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1680_1681	CRAL-TRIO.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCTATATCTATAACTGTAACTC	0.46			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29653043	A	A	29653042	7	5	84	1	0	1	1	0	0	0	0	0	10356	1413	49	0	5247	0	NF1	17	29653042	Frame_Shift_Ins	INS	-	TCGA-06-2569-01A-01D-1494-08	21358	29653042	51542168	31	5730											
GAS2L2	246176	broad.mit.edu	37	chr17	34073121	34073121	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcctgaggcccaggcactcGgctgggccaaaggaacgagg	16	12	0	1			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr17:34073121G>A	uc002hjv.1	-	6	1423	c.1395C>T	c.(1393-1395)GCC>GCT	p.A465A		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	465					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCAGGCACTCGGCTGGGCCAA	0.622													A	34073121	A	A	34073121	2	1	84	1	0	0	0	0	0	0	0	1	6247	1103	39	2		2	GAS2L2	17	34073121	Silent	SNP	G	TCGA-06-2569-01A-01D-1494-08	4420079	34073121	47122089	32	5731											
ACACA	31	broad.mit.edu	37	chr17	35444255	35444255	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcaggaagctcttcctacGtggaaggggaatccattgtg	14	8	1	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr17:35444255G>A	uc002hnm.2	-	56	7228	c.7037C>T	c.(7036-7038)ACG>ATG	p.T2346M	ACACA_uc002hnk.2_Missense_Mutation_p.T2268M|ACACA_uc002hnl.2_Missense_Mutation_p.T2288M|ACACA_uc002hnn.2_Missense_Mutation_p.T2346M|ACACA_uc002hno.2_Missense_Mutation_p.T2383M|ACACA_uc010cuy.2_Missense_Mutation_p.T991M|ACACA_uc010wdb.1_Missense_Mutation_p.T384M|ACACA_uc010wdc.1_Missense_Mutation_p.T472M	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	2346					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTCTTCCTACGTGGAAGGGGA	0.517													A	35444255	A	A	35444255	3	1	84	1	0	0	0	0	1	0	0	0	106	1145	40	1	7	1	ACACA	17	35444255	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08	1371134	35444255	45750955	33	5732											
FADS6	283985	broad.mit.edu	37	chr17	72875610	72875610	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgatgatcgagtggccgaacGcccagtccagcacgggcagc	14	13	0	2			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr17:72875610G>C	uc002jmd.1	-	5	842	c.830C>G	c.(829-831)GCG>GGG	p.A277G	FADS6_uc010wrn.1_Missense_Mutation_p.A131G	NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	283	Helical; (Potential).				fatty acid biosynthetic process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)					GTGGCCGAACGCCCAGTCCAG	0.612													C	72875610	C	C	72875610	3	2	84	1	0	0	0	0	1	0	0	0	5368	1087	38	5	230	5	FADS6	17	72875610	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08	37431355	72875610	8319600	34	5733											
KLK15	55554	broad.mit.edu	37	chr19	51330190	51330190	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgtgggacaccaggccccagCcagacaccacacaggcctcc	10	18	0	1			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr19:51330190C>A	uc002ptl.2	-	3	456	c.425G>T	c.(424-426)GGC>GTC	p.G142V	KLK15_uc002ptm.2_Intron|KLK15_uc002ptn.2_Missense_Mutation_p.G142V|KLK15_uc002pto.2_Missense_Mutation_p.G141V|KLK15_uc010ych.1_Intron|KLK15_uc010yci.1_Missense_Mutation_p.G141V|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	142	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CAGGCCCCAGCCAGACACCAC	0.692													A	51330190	A	A	51330190	3	1	84	1	0	0	0	0	1	0	0	0	8403	739	26	5	357	5	KLK15	19	51330190	Missense_Mutation	SNP	C	TCGA-06-2569-01A-01D-1494-08		51330190	7798793	35	5734											
CD93	22918	broad.mit.edu	37	chr20	23065723	23065723	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccggctcatagccaacccaGcattcgcagcggaagccccc	9	19	1	0			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr20:23065723G>A	uc002wsv.2	-	1	1255	c.1107C>T	c.(1105-1107)TGC>TGT	p.C369C		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	369	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					AGCCAACCCAGCATTCGCAGC	0.642													A	23065723	A	A	23065723	2	1	84	1	0	0	0	0	0	0	0	1	3047	963	34	3		3	CD93	20	23065723	Silent	SNP	G	TCGA-06-2569-01A-01D-1494-08		23065723	39959797	36	5735											
MANBAL	63905	broad.mit.edu	37	chr20	35944753	35944753	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaagtgctgaggtgacgaggAagcccaaggctgctgttcct	15	9	0	2			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chr20:35944753A>G	uc002xgu.2	+	4	405	c.193A>G	c.(193-195)AAG>GAG	p.K65E	MANBAL_uc002xgv.2_Missense_Mutation_p.K65E|MANBAL_uc002xgw.2_RNA|MANBAL_uc010gfx.2_RNA|MANBAL_uc010gfy.2_RNA	NM_022077	NP_071360	Q9NQG1	MANBL_HUMAN	mannosidase, beta A, lysosomal-like	65						integral to membrane					0		Myeloproliferative disorder(115;0.00878)				GGTGACGAGGAAGCCCAAGGC	0.552													G	35944753	G	G	35944753	3	3	84	1	0	0	0	0	1	0	0	0	9220	247	9	4	199	4	MANBAL	20	35944753	Missense_Mutation	SNP	A	TCGA-06-2569-01A-01D-1494-08	12879030	35944753	27080767	37	5736											
PCDH19	57526	broad.mit.edu	37	chrX	99663291	99663291	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agctggacatgacctcgagcGagatgatgcacttggggctc	14	10	0	3			TCGA-06-2569-01A-01D-1494-08	TCGA-06-2569-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	617eec0b-78e9-4663-946c-c01e7e00a7de	586ddb97-949c-4bd1-97e0-d4db231b9828	g.chrX:99663291G>A	uc010nmz.2	-	1	1981	c.305C>T	c.(304-306)TCG>TTG	p.S102L	PCDH19_uc004efw.3_Missense_Mutation_p.S102L|PCDH19_uc004efx.3_Missense_Mutation_p.S102L	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	102	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GACCTCGAGCGAGATGATGCA	0.557													A	99663291	A	A	99663291	3	1	84	1	0	0	0	0	1	0	0	0	11514	1059	37	2	3165	2	PCDH19	23	99663291	Missense_Mutation	SNP	G	TCGA-06-2569-01A-01D-1494-08		99663291	55607269	38	5737											
WDR78	79819	broad.mit.edu	37	chr1	67313167	67313167	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtttattttttttaaatacCttttaaaacaggaagctgac	5	5	0	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr1:67313167C>T	uc001dcx.2	-	8	1347	c.1291G>A	c.(1291-1293)GAA>AAA	p.E431K	WDR78_uc001dcy.2_Missense_Mutation_p.E431K|WDR78_uc009waw.2_Missense_Mutation_p.E177K|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	431	Glu-rich.									ovary(2)	2						TTTTAAATACCTTTTAAAACA	0.199													T	67313167	T	T	67313167	3	4	85	1	0	0	0	0	1	0	0	0	17325	695	24	3	1352	3	WDR78	1	67313167	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08		67313167	181937454	1	5738											
FLG	2312	broad.mit.edu	37	chr1	152278655	152278655	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cccagaccacctctcagagtCttctgaatgtccctcactgt	6	16	4	3			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr1:152278655C>T	uc001ezu.1	-	3	8743	c.8707G>A	c.(8707-8709)GAC>AAC	p.D2903N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2903	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTCAGAGTCTTCTGAATGT	0.562									Ichthyosis				T	152278655	T	T	152278655	3	4	85	1	0	0	0	0	1	0	0	0	5922	913	32	3	3482	3	FLG	1	152278655	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	84965488	152278655	96971966	2	5739											
OR2W3	343171	broad.mit.edu	37	chr1	248059605	248059605	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaggcagaaggccttcggCacctgcggctcccatctcac	12	15	1	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr1:248059605C>T	uc001idp.1	+	3	986	c.717C>T	c.(715-717)GGC>GGT	p.G239G	OR2W3_uc010pzb.1_Silent_p.G239G	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	239	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGGCCTTCGGCACCTGCGGCT	0.522													T	248059605	T	T	248059605	2	4	85	1	0	0	0	0	0	0	0	1	11033	697	25	3		3	OR2W3	1	248059605	Silent	SNP	C	TCGA-06-2570-01A-01D-1495-08	95780950	248059605	1191016	3	5740											
C2orf55	343990	broad.mit.edu	37	chr2	99438353	99438353	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagcggccttttctccgccgTcctgggctccttcctgggtt	11	16	1	0			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr2:99438353T>C	uc002szf.1	-	7	2677	c.2383A>G	c.(2383-2385)ACG>GCG	p.T795A		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	795	Pro-rich.										0						TTCTCCGCCGTCCTGGGCTCC	0.721													C	99438353	C	C	99438353	3	2	85	1	0	0	0	0	1	0	0	0	2176	1667	58	4	521	4	C2orf55	2	99438353	Missense_Mutation	SNP	T	TCGA-06-2570-01A-01D-1495-08		99438353	143761020	4	5741											
RIF1	55183	broad.mit.edu	37	chr2	152322631	152322631	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaatctcatcacctgttaaTaaggtaaggggaatgaggct	11	6	2	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr2:152322631T>C	uc002txm.2	+	30	6727	c.6597T>C	c.(6595-6597)AAT>AAC	p.N2199N	RIF1_uc002txl.2_Silent_p.N2199N|RIF1_uc002txn.2_Silent_p.N2199N|RIF1_uc002txo.2_Silent_p.N2199N|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	2199	Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		CACCTGTTAATAAGGTAAGGG	0.398													C	152322631	C	C	152322631	2	2	85	1	0	0	0	0	0	0	0	1	13359	1403	49	4		4	RIF1	2	152322631	Silent	SNP	T	TCGA-06-2570-01A-01D-1495-08	52884278	152322631	90876742	5	5742											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	85	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	56790481	209113112	34086261	6	5743											
RUFY4	285180	broad.mit.edu	37	chr2	218940356	218940356	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgggtccttcagggacacGcaacaaaggaagactctacc	10	13	2	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr2:218940356G>A	uc002vgw.2	+	10	2466	c.622G>A	c.(622-624)GCA>ACA	p.A208T	RUFY4_uc002vgy.1_RNA|RUFY4_uc010fvl.1_Missense_Mutation_p.A208T	NM_198483	NP_940885	Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	381							metal ion binding			pancreas(1)	1		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TCAGGGACACGCAACAAAGGA	0.622													A	218940356	A	A	218940356	3	1	85	1	0	0	0	0	1	0	0	0	13741	1087	38	1	1167	1	RUFY4	2	218940356	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08	9827244	218940356	24259017	7	5744											
CHRND	1144	broad.mit.edu	37	chr2	233392979	233392979	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tttgggattccagggctggaCagacaaccggctgaagtgga	15	8	0	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr2:233392979C>A	uc002vsw.2	+	4	255	c.251C>A	c.(250-252)ACA>AAA	p.T84K	CHRND_uc010zmg.1_Missense_Mutation_p.T69K|CHRND_uc010fyc.2_5'UTR|CHRND_uc010zmh.1_5'UTR	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	84	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		CAGGGCTGGACAGACAACCGG	0.577													A	233392979	A	A	233392979	3	1	85	1	0	0	0	0	1	0	0	0	3394	478	17	5	265	5	CHRND	2	233392979	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	14452623	233392979	9806394	8	5745											
FARP2	9855	broad.mit.edu	37	chr2	242423744	242423744	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttcccctccaaggcatgCtggtgagtggtcttgcaccc	10	15	1	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr2:242423744C>T	uc002wbi.1	+	21	2536	c.2419C>T	c.(2419-2421)CTG>TTG	p.L807L		NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	807	PH 1.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		CCAAGGCATGCTGGTGAGTGG	0.587													T	242423744	T	T	242423744	2	4	85	1	0	0	0	0	0	0	0	1	5677	796	28	3		3	FARP2	2	242423744	Silent	SNP	C	TCGA-06-2570-01A-01D-1495-08	9030765	242423744	775629	9	5746											
CCR3	1232	broad.mit.edu	37	chr3	46307517	46307517	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctggtgacagaggtgatcGcctactcccactgctgcatg	12	12	0	3			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr3:46307517G>A	uc003cpg.1	+	4	1411	c.868G>A	c.(868-870)GCC>ACC	p.A290T	CCR3_uc003cpi.1_Missense_Mutation_p.A290T|CCR3_uc003cpj.1_Missense_Mutation_p.A290T|CCR3_uc003cpk.1_Missense_Mutation_p.A311T|CCR3_uc010hjb.1_Missense_Mutation_p.A308T|CCR3_uc003cpl.1_Missense_Mutation_p.A323T	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	290	Helical; Name=7; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		AGAGGTGATCGCCTACTCCCA	0.522													A	46307517	A	A	46307517	3	1	85	1	0	0	0	0	1	0	0	0	2942	1087	38	1	937	1	CCR3	3	46307517	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08		46307517	151714913	10	5747											
DNAH1	25981	broad.mit.edu	37	chr3	52417902	52417902	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggagaggtcttccgagctcGtctgaggcagtttccctccc	12	14	2	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr3:52417902G>A	uc011bef.1	+	52	8438	c.8177G>A	c.(8176-8178)CGT>CAT	p.R2726H	DNAH1_uc003ddv.2_5'Flank	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2726	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TTCCGAGCTCGTCTGAGGCAG	0.587													A	52417902	A	A	52417902	3	1	85	1	0	0	0	0	1	0	0	0	4597	1145	40	1	8379	1	DNAH1	3	52417902	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08	6110385	52417902	145604528	11	5748											
PPP2R3A	5523	broad.mit.edu	37	chr3	135721982	135721982	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atagtcacagtcagttgaccGgtcagacccttgtagatctt	9	10	4	3			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr3:135721982G>A	uc003eqv.1	+	2	2207	c.1642G>A	c.(1642-1644)GGT>AGT	p.G548S	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	548					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						TCAGTTGACCGGTCAGACCCT	0.398													A	135721982	A	A	135721982	3	1	85	1	0	0	0	0	1	0	0	0	12388	1116	39	2	1644	2	PPP2R3A	3	135721982	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08	83304080	135721982	62300448	12	5749											
PIK3CA	5290	broad.mit.edu	37	chr3	178936083	178936083	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tacacgagatcctctctctgAaatcactgagcaggagaaag	9	10	3	4			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr3:178936083A>T	uc003fjk.2	+	10	1782	c.1625A>T	c.(1624-1626)GAA>GTA	p.E542V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCTCTCTCTGAAATCACTGAG	0.333		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			T	178936083	T	T	178936083	3	4	85	1	0	0	0	0	1	0	0	0	11913	246	9	5	1659	5	PIK3CA	3	178936083	Missense_Mutation	SNP	A	TCGA-06-2570-01A-01D-1495-08	43214101	178936083	19086347	13	5750											
LEPREL1	55214	broad.mit.edu	37	chr3	189681756	189681756	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagaaactcaccaattctctAtaaagtgggtccaaggtgaa	9	8	2	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr3:189681756A>G	uc011bsk.1	-	14	2413	c.2025T>C	c.(2023-2025)TAT>TAC	p.Y675Y	LEPREL1_uc003fsg.2_Silent_p.Y494Y	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	675					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CCAATTCTCTATAAAGTGGGT	0.483													G	189681756	G	G	189681756	2	3	85	1	0	0	0	0	0	0	0	1	8730	456	16	4		4	LEPREL1	3	189681756	Silent	SNP	A	TCGA-06-2570-01A-01D-1495-08	10745673	189681756	8340674	14	5751											
ADAMTS16	170690	broad.mit.edu	37	chr5	5239938	5239938	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccgtggactggcccggccGgtacaaattttcgggcacta	13	12	0	0			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr5:5239938G>A	uc003jdl.2	+	16	2561	c.2423G>A	c.(2422-2424)CGG>CAG	p.R808Q	ADAMTS16_uc003jdk.1_Missense_Mutation_p.R808Q	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	808	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TGGCCCGGCCGGTACAAATTT	0.512													A	5239938	A	A	5239938	3	1	85	1	0	0	0	0	1	0	0	0	261	1116	39	2	2485	2	ADAMTS16	5	5239938	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08		5239938	175675322	15	5752											
SKP2	6502	broad.mit.edu	37	chr5	36171807	36171807	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcacccagctgaatcttagCggctacagaaagaatctcca	7	12	3	3			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr5:36171807C>A	uc003jkc.1	+	7	1055	c.873C>A	c.(871-873)AGC>AGA	p.S291R	SKP2_uc011cou.1_Missense_Mutation_p.S77R|SKP2_uc003jkd.2_Missense_Mutation_p.S291R	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	291	LRR 6.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGAATCTTAGCGGCTACAGAA	0.463													A	36171807	A	A	36171807	3	1	85	1	0	0	0	0	1	0	0	0	14362	767	27	5	899	5	SKP2	5	36171807	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	30931869	36171807	144743453	16	5753											
HCN1	348980	broad.mit.edu	37	chr5	45695974	45695974	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aagccccccgccggctcctcGccgccgccgccgccgccgcc	11	26	0	0			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr5:45695974G>C	uc003jok.2	-	1	247	c.222C>G	c.(220-222)GGC>GGG	p.G74G		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	74	Cytoplasmic (Potential).|Gly-rich.					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CCGGCTCCTcgccgccgccgc	0.423													C	45695974	C	C	45695974	2	2	85	1	0	0	0	0	0	0	0	1	6996	1074	38	5		5	HCN1	5	45695974	Silent	SNP	G	TCGA-06-2570-01A-01D-1495-08	9524167	45695974	135219286	17	5754											
MAP3K1	4214	broad.mit.edu	37	chr5	56177898	56177898	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaccaaagccaatggttcaAacaaaaggcagaccccacag	7	13	1	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr5:56177898A>G	uc003jqw.3	+	14	3372	c.2871A>G	c.(2869-2871)CAA>CAG	p.Q957Q		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	957					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		CAATGGTTCAAACAAAAGGCA	0.398													G	56177898	G	G	56177898	2	3	85	1	0	0	0	0	0	0	0	1	9243	11	1	4		4	MAP3K1	5	56177898	Silent	SNP	A	TCGA-06-2570-01A-01D-1495-08	10481924	56177898	124737362	18	5755											
ELOVL7	79993	broad.mit.edu	37	chr5	60053463	60053463	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttagaagggcatggaatgttCccaaaccacctggaaaataa	9	8	0	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr5:60053463C>T	uc003jsi.3	-	8	709	c.509G>A	c.(508-510)GGA>GAA	p.G170E	ELOVL7_uc011cqo.1_Missense_Mutation_p.G83E|ELOVL7_uc010iwk.2_Missense_Mutation_p.G170E|ELOVL7_uc003jsj.3_Missense_Mutation_p.G157E	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	170					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				ATGGAATGTTCCCAAACCACC	0.378													T	60053463	T	T	60053463	3	4	85	1	0	0	0	0	1	0	0	0	5079	855	30	3	344	3	ELOVL7	5	60053463	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	3875565	60053463	120861797	19	5756											
KCNK16	83795	broad.mit.edu	37	chr6	39285601	39285601	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcccatctttcaatggcGgccagatgggcacgcagccc	10	16	2	1	rs79043904		TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr6:39285601G>A	uc003ooq.2	-	3	470	c.456C>T	c.(454-456)GCC>GCT	p.A152A	KCNK16_uc003oor.3_Silent_p.A152A|KCNK16_uc010jwy.2_Silent_p.A152A|KCNK16_uc011dtz.1_Silent_p.A152A	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	152	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						TTTCAATGGCGGCCAGATGGG	0.552													A	39285601	A	A	39285601	2	1	85	1	0	0	0	0	0	0	0	1	8063	1103	39	2		2	KCNK16	6	39285601	Silent	SNP	G	TCGA-06-2570-01A-01D-1495-08		39285601	131829466	20	5757											
AVL9	23080	broad.mit.edu	37	chr7	32598232	32598232	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actgatgactgtgttatcccTttttccaggtaagaaaacag	8	8	0	3			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr7:32598232T>C	uc003tcv.1	+	9	817	c.671T>C	c.(670-672)CTT>CCT	p.L224P	AVL9_uc011kai.1_Missense_Mutation_p.L224P|AVL9_uc010kwj.1_Missense_Mutation_p.L65P	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	224	Helical; (Potential).					integral to membrane					0						GTGTTATCCCTTTTTCCAGGT	0.328													C	32598232	C	C	32598232	3	2	85	1	0	0	0	0	1	0	0	0	1228	1609	56	4	705	4	AVL9	7	32598232	Missense_Mutation	SNP	T	TCGA-06-2570-01A-01D-1495-08		32598232	126540431	21	5758											
ABCB4	5244	broad.mit.edu	37	chr7	87069034	87069034	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttctgtgtccaatgctgaCgtggcctcatccagcagaag	10	12	2	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr7:87069034C>T	uc003uiv.1	-	14	1756	c.1680G>A	c.(1678-1680)ACG>ACA	p.T560T	ABCB4_uc003uiw.1_Silent_p.T560T|ABCB4_uc003uix.1_Silent_p.T560T	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	560	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CCAATGCTGACGTGGCCTCAT	0.537													T	87069034	T	T	87069034	2	4	85	1	0	0	0	0	0	0	0	1	43	523	19	1		1	ABCB4	7	87069034	Silent	SNP	C	TCGA-06-2570-01A-01D-1495-08	54470802	87069034	72069629	22	5759											
ABCB1	5243	broad.mit.edu	37	chr7	87133728	87133728	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagcaatcacaatgcaggtgCggccttctctggctttgtcc	11	12	2	0			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr7:87133728C>T	uc003uiz.1	-	29	4092	c.3674G>A	c.(3673-3675)CGC>CAC	p.R1225H	ABCB1_uc011khc.1_Missense_Mutation_p.R1161H	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	1225	Cytoplasmic (Potential).|ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AATGCAGGTGCGGCCTTCTCT	0.453													T	87133728	T	T	87133728	3	4	85	1	0	0	0	0	1	0	0	0	40	768	27	1	172	1	ABCB1	7	87133728	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	64694	87133728	72004935	23	5760											
LRRC6	23639	broad.mit.edu	37	chr8	133584685	133584685	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gttagtcacatcagggaatgAgtgcttgctagggtctactt	12	7	3	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr8:133584685A>T	uc003ytk.2	-	12	1344	c.1270T>A	c.(1270-1272)TCA>ACA	p.S424T	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	424						cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TCAGGGAATGAGTGCTTGCTA	0.373													T	133584685	T	T	133584685	3	4	85	1	0	0	0	0	1	0	0	0	9016	304	11	5	134	5	LRRC6	8	133584685	Missense_Mutation	SNP	A	TCGA-06-2570-01A-01D-1495-08		133584685	12779337	24	5761											
NDRG1	10397	broad.mit.edu	37	chr8	134258899	134258899	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgggtccaattttgagttgCactccacctgcacaagaggg	11	10	0	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr8:134258899C>T	uc003yuh.2	-	13	1401	c.815G>A	c.(814-816)TGC>TAC	p.C272Y	NDRG1_uc003yue.1_5'Flank|NDRG1_uc003yuf.1_Missense_Mutation_p.C83Y|NDRG1_uc003yug.2_Missense_Mutation_p.C272Y|NDRG1_uc010mee.2_Missense_Mutation_p.C191Y|NDRG1_uc010mef.2_Missense_Mutation_p.C206Y|NDRG1_uc011ljh.1_Missense_Mutation_p.C100Y|NDRG1_uc011lji.1_Missense_Mutation_p.C19Y	NM_001135242	NP_001128714	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	272					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			TTTTGAGTTGCACTCCACCTG	0.473													T	134258899	T	T	134258899	3	4	85	1	0	0	0	0	1	0	0	0	10251	710	25	3	385	3	NDRG1	8	134258899	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	674214	134258899	12105123	25	5762											
RASEF	158158	broad.mit.edu	37	chr9	85615141	85615141	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcaaagtctcatgaggaaacTagacttccccactgcagcgt	9	12	1	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr9:85615141T>C	uc004amo.1	-	12	1927	c.1666A>G	c.(1666-1668)AGT>GGT	p.S556G		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	556					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						ATGAGGAAACTAGACTTCCCC	0.458													C	85615141	C	C	85615141	3	2	85	1	0	0	0	0	1	0	0	0	13068	1522	53	4	580	4	RASEF	9	85615141	Missense_Mutation	SNP	T	TCGA-06-2570-01A-01D-1495-08		85615141	55598290	26	5763											
GYLTL1B	120071	broad.mit.edu	37	chr11	45945056	45945056	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccatcgtgtgtgcggggcaTaactccagccgagacgtcat	13	12	1	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr11:45945056T>C	uc001nbv.1	+	3	429	c.318T>C	c.(316-318)CAT>CAC	p.H106H	GYLTL1B_uc001nbw.1_Silent_p.H75H|GYLTL1B_uc001nbx.1_Silent_p.H106H|GYLTL1B_uc001nby.1_5'Flank	NM_152312	NP_689525	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	106	Lumenal (Potential).				muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.226)		GTGCGGGGCATAACTCCAGCC	0.627													C	45945056	C	C	45945056	2	2	85	1	0	0	0	0	0	0	0	1	6907	1403	49	4		4	GYLTL1B	11	45945056	Silent	SNP	T	TCGA-06-2570-01A-01D-1495-08		45945056	89061460	27	5764											
AMBRA1	55626	broad.mit.edu	37	chr11	46568697	46568697	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcctaacctccccatctaggCagccagaagcaataaggcct	7	15	1	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr11:46568697C>A	uc010rgu.1	-	4	704	c.344G>T	c.(343-345)TGC>TTC	p.C115F	AMBRA1_uc009ylc.1_Missense_Mutation_p.C115F|AMBRA1_uc001ncu.1_Missense_Mutation_p.C115F|AMBRA1_uc001ncv.2_Missense_Mutation_p.C115F|AMBRA1_uc001ncw.2_Missense_Mutation_p.C115F|AMBRA1_uc001ncx.2_Missense_Mutation_p.C115F	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	115	WD 2.				autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		CCCATCTAGGCAGCCAGAAGC	0.408													A	46568697	A	A	46568697	3	1	85	1	0	0	0	0	1	0	0	0	565	710	25	5	3346	5	AMBRA1	11	46568697	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	623641	46568697	88437819	28	5765											
DDB2	1643	broad.mit.edu	37	chr11	47254492	47254492	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caacattctacgagtttttgCcagctcagacaccatcaagt	6	12	3	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr11:47254492C>T	uc001neb.2	+	4	779	c.584C>T	c.(583-585)GCC>GTC	p.A195V	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Missense_Mutation_p.A131V|DDB2_uc001ned.2_Intron|DDB2_uc001nee.2_Intron|DDB2_uc001nef.2_Intron|DDB2_uc001neg.2_Missense_Mutation_p.A59V|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	195	WD 2.				nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						CGAGTTTTTGCCAGCTCAGAC	0.453			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				T	47254492	T	T	47254492	3	4	85	1	0	0	0	0	1	0	0	0	4324	739	26	3	598	3	DDB2	11	47254492	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	685795	47254492	87752024	29	5766											
INTS5	80789	broad.mit.edu	37	chr11	62416142	62416142	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agcgcatctaaaaagggcacCaagcggggaggtgggggcgg	19	8	1	0			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr11:62416142C>A	uc001nud.2	-	2	1463	c.1410G>T	c.(1408-1410)TTG>TTT	p.L470F	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	470					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						AAAAGGGCACCAAGCGGGGAG	0.592													A	62416142	A	A	62416142	3	1	85	1	0	0	0	0	1	0	0	0	7781	593	21	5	1653	5	INTS5	11	62416142	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	15161650	62416142	72590374	30	5767											
KCNK4	50801	broad.mit.edu	37	chr11	64064379	64064379	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgccctgggagggggtgcGgacccagaaaccaactcgac	15	12	0	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr11:64064379G>A	uc001nzj.1	+	3	542	c.219G>A	c.(217-219)GCG>GCA	p.A73A	KCNK4_uc009ypl.1_Missense_Mutation_p.R7Q|KCNK4_uc001nzk.1_Missense_Mutation_p.R7Q|KCNK4_uc010rnk.1_5'UTR|KCNK4_uc001nzl.1_Missense_Mutation_p.R7Q|KCNK4_uc001nzm.3_RNA|KCNK4_uc001nzn.1_Silent_p.A73A|KCNK4_uc001nzo.2_Silent_p.A73A|KCNK4_uc001nzp.1_5'UTR	NM_033310	NP_201567	Q9NYG8	KCNK4_HUMAN	TRAAK	73						integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						GAGGGGGTGCGGACCCAGAAA	0.617													A	64064379	A	A	64064379	2	1	85	1	0	0	0	0	0	0	0	1	8068	1103	39	2		2	KCNK4	11	64064379	Silent	SNP	G	TCGA-06-2570-01A-01D-1495-08	1648237	64064379	70942137	31	5768											
IRAK3	11213	broad.mit.edu	37	chr12	66597538	66597538	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgttcgtcatattgaaaagTatgtagaccaaggtaaaagt	9	4	1	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr12:66597538T>C	uc001sth.2	+	2	283	c.181T>C	c.(181-183)TAT>CAT	p.Y61H	IRAK3_uc010ssy.1_Intron	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	61	Death.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		TATTGAAAAGTATGTAGACCA	0.398													C	66597538	C	C	66597538	3	2	85	1	0	0	0	0	1	0	0	0	7824	1638	57	4	187	4	IRAK3	12	66597538	Missense_Mutation	SNP	T	TCGA-06-2570-01A-01D-1495-08		66597538	67254357	32	5769											
STK24	8428	broad.mit.edu	37	chr13	99127230	99127230	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcagacagcaggacgttggCcgctgcaaaagaaagccaag	12	11	1	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr13:99127230C>T	uc001vnm.1	-	5	713	c.478G>A	c.(478-480)GCC>ACC	p.A160T	STK24_uc001vnn.1_Missense_Mutation_p.A148T|STK24_uc010tim.1_Missense_Mutation_p.A129T	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	160	Protein kinase.				cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGGACGTTGGCCGCTGCAAAA	0.627													T	99127230	T	T	99127230	3	4	85	1	0	0	0	0	1	0	0	0	15292	739	26	3	881	3	STK24	13	99127230	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08		99127230	16042648	33	5770											
POTEG	404785	broad.mit.edu	37	chr14	19566050	19566050	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgactacaaagaaaaacagaTgctaaaagtctcttctgaaa	6	7	2	4			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr14:19566050T>C	uc001vuz.1	+	6	1146	c.1094T>C	c.(1093-1095)ATG>ACG	p.M365T	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA|uc001vvb.2_Intron	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	365				M -> I (in Ref. 1; AAS58868).						ovary(1)	1						GAAAAACAGATGCTAAAAGTC	0.229													C	19566050	C	C	19566050	3	2	85	1	0	0	0	0	1	0	0	0	12266	1464	51	4	1116	4	POTEG	14	19566050	Missense_Mutation	SNP	T	TCGA-06-2570-01A-01D-1495-08		19566050	87783490	34	5771											
NFATC4	4776	broad.mit.edu	37	chr14	24838971	24838971	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tccgcatcacctccatctctCccacgccggagccgccagca	7	21	2	0			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr14:24838971C>T	uc001wpc.2	+	2	688	c.367C>T	c.(367-369)CCC>TCC	p.P123S	NFATC4_uc010tok.1_Missense_Mutation_p.P186S|NFATC4_uc010tol.1_Missense_Mutation_p.P186S|NFATC4_uc010alr.2_Missense_Mutation_p.P186S|NFATC4_uc010als.2_Missense_Mutation_p.P136S|NFATC4_uc010tom.1_Missense_Mutation_p.P136S|NFATC4_uc010ton.1_Missense_Mutation_p.P136S|NFATC4_uc010too.1_Missense_Mutation_p.P136S|NFATC4_uc010alt.2_Missense_Mutation_p.P155S|NFATC4_uc010top.1_Missense_Mutation_p.P155S|NFATC4_uc010toq.1_Missense_Mutation_p.P155S|NFATC4_uc010alu.2_Intron|NFATC4_uc010tor.1_Missense_Mutation_p.P123S|NFATC4_uc010tos.1_Missense_Mutation_p.P53S|NFATC4_uc010tot.1_Missense_Mutation_p.P111S|NFATC4_uc010tou.1_Missense_Mutation_p.P53S|NFATC4_uc010tov.1_Missense_Mutation_p.P111S|NFATC4_uc010tow.1_Missense_Mutation_p.P53S|NFATC4_uc010alv.2_Missense_Mutation_p.P111S|NFATC4_uc010tox.1_Missense_Mutation_p.P53S	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	123	Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		CTCCATCTCTCCCACGCCGGA	0.577													T	24838971	T	T	24838971	3	4	85	1	0	0	0	0	1	0	0	0	10365	855	30	3	566	3	NFATC4	14	24838971	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	5272921	24838971	82510569	35	5772											
MLH3	27030	broad.mit.edu	37	chr14	75514227	75514227	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ggaaagagggggatgtatcaGataatatgcaatctgtttgt	13	3	2	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr14:75514227G>C	uc001xrd.1	-	2	2348	c.2132C>G	c.(2131-2133)TCT>TGT	p.S711C	MLH3_uc001xre.1_Missense_Mutation_p.S711C|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	711					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		GGATGTATCAGATAATATGCA	0.363								MMR					C	75514227	C	C	75514227	3	2	85	1	0	0	0	0	1	0	0	0	9618	942	33	5	2277	5	MLH3	14	75514227	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08	50675256	75514227	31835313	36	5773											
PKD1L2	114780	broad.mit.edu	37	chr16	81134885	81134885	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctacgatctccccttcctccGacagctgcaagagaaagaac	7	15	1	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr16:81134885G>A	uc002fgh.1	-	45	7223	c.7223C>T	c.(7222-7224)TCG>TTG	p.S2408L	PKD1L2_uc002fgf.1_Missense_Mutation_p.S208L|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2408	Extracellular (Potential).|Interaction with GNAS and GNAI1.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCCTTCCTCCGACAGCTGCAA	0.443													A	81134885	A	A	81134885	3	1	85	1	0	0	0	0	1	0	0	0	11965	1059	37	2	160	2	PKD1L2	16	81134885	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08		81134885	9219868	37	5774											
TP53	7157	broad.mit.edu	37	chr17	7578524	7578524	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agggcaggtcttggccagttGgcaaaacatcttgttgaggg	15	7	2	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr17:7578524G>C	uc002gim.2	-	5	600	c.406C>G	c.(406-408)CAA>GAA	p.Q136E	TP53_uc002gig.1_Missense_Mutation_p.Q136E|TP53_uc002gih.2_Missense_Mutation_p.Q136E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Q4E|TP53_uc010cng.1_Missense_Mutation_p.Q4E|TP53_uc002gii.1_Missense_Mutation_p.Q4E|TP53_uc010cnh.1_Missense_Mutation_p.Q136E|TP53_uc010cni.1_Missense_Mutation_p.Q136E|TP53_uc002gij.2_Missense_Mutation_p.Q136E|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Q43E|TP53_uc002gio.2_Missense_Mutation_p.Q4E|TP53_uc010vug.1_Missense_Mutation_p.Q97E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	136	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q136*(28)|p.0?(7)|p.Q136H(5)|p.Q136Q(4)|p.Q136P(3)|p.Q136E(3)|p.N131fs*27(2)|p.Q136fs*13(2)|p.Q136R(2)|p.Q136fs*34(2)|p.V73fs*9(1)|p.F134_T140>S(1)|p.C135_T140delCQLAKT(1)|p.Q136K(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.Q136_K139delQLAK(1)|p.C135_Q136insX(1)|p.C135_Q136insXXXXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGCCAGTTGGCAAAACATC	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578524	C	C	7578524	3	2	85	1	0	0	0	0	1	0	0	0	16378	1357	47	5	892	5	TP53	17	7578524	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08		7578524	73616686	38	5775											
AMAC1	146861	broad.mit.edu	37	chr17	33520927	33520927	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gacggtggaagaacctttgcGaacagtggcagcgttgccag	15	9	0	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr17:33520927G>A	uc002hjd.2	-	1	486	c.400C>T	c.(400-402)CGC>TGC	p.R134C		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	134	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		GAACCTTTGCGAACAGTGGCA	0.607													A	33520927	A	A	33520927	3	1	85	1	0	0	0	0	1	0	0	0	559	1058	37	2	620	2	AMAC1	17	33520927	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08	25942403	33520927	47674283	39	5776											
SPATA20	64847	broad.mit.edu	37	chr17	48626428	48626428	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcagcggcgggggctggCccatgaatgtgtggctgact	17	11	0	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr17:48626428C>T	uc002irf.2	+	5	634	c.493C>T	c.(493-495)CCC>TCC	p.P165S	SPATA20_uc002irc.2_5'UTR|SPATA20_uc002ire.2_Missense_Mutation_p.P121S|SPATA20_uc002ird.2_Missense_Mutation_p.P181S|SPATA20_uc010wmv.1_Missense_Mutation_p.P191S|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	165					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CGGGGGCTGGCCCATGAATGT	0.657													T	48626428	T	T	48626428	3	4	85	1	0	0	0	0	1	0	0	0	15005	739	26	3	563	3	SPATA20	17	48626428	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	15105501	48626428	32568782	40	5777											
TYK2	7297	broad.mit.edu	37	chr19	10473108	10473108	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatggggaactttcggagccGcaagctctgcatgccgtctg	13	11	2	0			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr19:10473108G>A	uc002moc.3	-	11	1879	c.1501C>T	c.(1501-1503)CGG>TGG	p.R501W	TYK2_uc010dxe.2_Missense_Mutation_p.R316W|TYK2_uc002mod.2_Missense_Mutation_p.R501W	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	501	SH2; atypical.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TTTCGGAGCCGCAAGCTCTGC	0.597													A	10473108	A	A	10473108	3	1	85	1	0	0	0	0	1	0	0	0	16807	1086	38	1	2122	1	TYK2	19	10473108	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08		10473108	48655875	41	5778											
CDH4	1002	broad.mit.edu	37	chr20	60504710	60504710	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcatcctgtacctggaggcCgggatgtatgacgtccccat	12	13	0	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr20:60504710C>T	uc002ybn.1	+	13	2063	c.2049C>T	c.(2047-2049)GCC>GCT	p.A683A	CDH4_uc002ybp.1_Silent_p.A609A	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	683	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			ACCTGGAGGCCGGGATGTATG	0.547													T	60504710	T	T	60504710	2	4	85	1	0	0	0	0	0	0	0	1	3112	639	23	2		2	CDH4	20	60504710	Silent	SNP	C	TCGA-06-2570-01A-01D-1495-08		60504710	2520810	42	5779											
C21orf29	54084	broad.mit.edu	37	chr21	45987844	45987845	+	Missense_Mutation	DNP	CC	AG	AG													tcctgatcccgcttgtggcgCcatcagaagggaccacttcc							TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr21:45987844_45987845CC>AG	uc002zfe.1	-	2	193_194	c.127_128GG>CT	c.(127-129)GGC>CTC	p.G43L	C21orf29_uc010gpv.1_5'UTR	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	43					cell adhesion	extracellular region	structural molecule activity				0						GCTTGTGGCGCCATCAGAAGGG	0.604													AG	45987845	AG	AG	45987844	3	1	85	1	0	0	0	0	1	0	0	0	2124	739	26	5	1925	5	C21orf29	21	45987844	Missense_Mutation	DNP	CC	TCGA-06-2570-01A-01D-1495-08		45987844	2142051	43	5780											
KRTAP12-4	386684	broad.mit.edu	37	chr21	46074201	46074201	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggccacctgctcagcagcCagtgggggtgctccaggtga	16	12	1	1			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chr21:46074201C>T	uc002zfs.1	-	1	376	c.331G>A	c.(331-333)GGC>AGC	p.G111S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198698	NP_941971	P60329	KR124_HUMAN	keratin associated protein 12-4	111						keratin filament				ovary(1)	1						GCTCAGCAGCCAGTGGGGGTG	0.622													T	46074201	T	T	46074201	3	4	85	1	0	0	0	0	1	0	0	0	8521	594	21	3	11	3	KRTAP12-4	21	46074201	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	86357	46074201	2055694	44	5781											
CDKL5	6792	broad.mit.edu	37	chrX	18597977	18597977	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttaatttttagaatatgctcGaattgctggaagaaatgcca	8	5	0	2			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chrX:18597977G>A	uc004cym.2	+	6	545	c.292G>A	c.(292-294)GAA>AAA	p.E98K	CDKL5_uc004cyn.2_Missense_Mutation_p.E98K	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	98	Protein kinase.				neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					GAATATGCTCGAATTGCTGGA	0.328													A	18597977	A	A	18597977	3	1	85	1	0	0	0	0	1	0	0	0	3157	1059	37	2	310	2	CDKL5	23	18597977	Missense_Mutation	SNP	G	TCGA-06-2570-01A-01D-1495-08		18597977	136672583	45	5782											
ZNF81	347344	broad.mit.edu	37	chrX	47775519	47775519	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tccagatgcataagagaattCatacaggagagaaaccctat	8	8	1	3			TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chrX:47775519C>A	uc010nhy.1	+	6	1842	c.1474C>A	c.(1474-1476)CAT>AAT	p.H492N		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	492	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				TAAGAGAATTCATACAGGAGA	0.413													A	47775519	A	A	47775519	3	1	85	1	0	0	0	0	1	0	0	0	18171	826	29	5	1488	5	ZNF81	23	47775519	Missense_Mutation	SNP	C	TCGA-06-2570-01A-01D-1495-08	29177542	47775519	107495041	46	5783											
ATRX	546	broad.mit.edu	37	chrX	76909633	76909636	+	Frame_Shift_Del	DEL	TTTC	-	-													tgaaccttaatacgtcgcctTttctttttctgtttatagct							TCGA-06-2570-01A-01D-1495-08	TCGA-06-2570-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	04339769-517c-448d-a7ca-951f83608c60	abef86c9-df6a-477e-99e9-b8d2ac0641d0	g.chrX:76909633_76909636delTTTC	uc004ecp.3	-	14	4501_4504	c.4269_4272delGAAA	c.(4267-4272)AAGAAAfs	p.K1423fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.K1385fs|ATRX_uc004eco.3_Frame_Shift_Del_p.K1208fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.K1355fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1423_1424					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TACGTCGCCTTTTCTTTTTCTGTT	0.328			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						-	76909636	-	-	76909633	7	5	85	1	0	1	0	1	0	0	0	0	1208	1838	64	0	3294	0	ATRX	23	76909633	Frame_Shift_Del	DEL	TTTC	TCGA-06-2570-01A-01D-1495-08	29134114	76909633	78360927	47	5784											
TRIM62	55223	broad.mit.edu	37	chr1	33625475	33625475	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctctagcatggccttctggCgttcacgcagcagccggtgc	12	15	3	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr1:33625475C>T	uc001bxb.2	-	3	1213	c.575G>A	c.(574-576)CGC>CAC	p.R192H		NM_018207	NP_060677	Q9BVG3	TRI62_HUMAN	tripartite motif-containing 62	192	Potential.					intracellular	zinc ion binding				0		Myeloproliferative disorder(586;0.0393)				GGCCTTCTGGCGTTCACGCAG	0.652													T	33625475	T	T	33625475	3	4	86	1	0	0	0	0	1	0	0	0	16534	768	27	1	864	1	TRIM62	1	33625475	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08		33625475	215625146	1	5785											
TIE1	7075	broad.mit.edu	37	chr1	43779028	43779028	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcacgcgctacctcttccGcatgcgggccagcattcagg	11	16	2	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr1:43779028G>A	uc001ciu.2	+	13	2229	c.2150G>A	c.(2149-2151)CGC>CAC	p.R717H	TIE1_uc010okd.1_Missense_Mutation_p.R717H|TIE1_uc010oke.1_Missense_Mutation_p.R672H|TIE1_uc009vwq.2_Missense_Mutation_p.R673H|TIE1_uc010okf.1_Missense_Mutation_p.R362H|TIE1_uc010okg.1_Missense_Mutation_p.R362H	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	717	Fibronectin type-III 3.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TACCTCTTCCGCATGCGGGCC	0.657													A	43779028	A	A	43779028	3	1	86	1	0	0	0	0	1	0	0	0	15890	1087	38	1	2200	1	TIE1	1	43779028	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	10153553	43779028	205471593	2	5786											
ZNHIT6	54680	broad.mit.edu	37	chr1	86173500	86173504	+	Frame_Shift_Del	DEL	CTTCT	-	-													tgttttatctccaagttatcCttctcttccttcacttctga							TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr1:86173500_86173504delCTTCT	uc001dlh.2	-	1	598_602	c.464_468delAGAAG	c.(463-468)GAGAAGfs	p.E155fs	ZNHIT6_uc010osc.1_Frame_Shift_Del_p.E116fs	NM_017953	NP_060423	Q9NWK9	BCD1_HUMAN	zinc finger, HIT type 6	155_156	Glu-rich.				box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			large_intestine(1)	1						CCAAGTTATCCTTCTCTTCCTTCAC	0.41													-	86173504	-	-	86173500	7	5	86	1	0	1	0	1	0	0	0	0	18206	680	24	0	984	0	ZNHIT6	1	86173500	Frame_Shift_Del	DEL	CTTCT	TCGA-06-5408-01A-01D-1696-08	42394472	86173500	163077121	3	5787											
FLG2	388698	broad.mit.edu	37	chr1	152325024	152325024	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctggcttggccatgagtgtgTcctgaatgtgtatgtgagac	14	7	0	3			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr1:152325024T>C	uc001ezw.3	-	3	5311	c.5238A>G	c.(5236-5238)GGA>GGG	p.G1746G	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1746							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGAGTGTGTCCTGAATGTG	0.502													C	152325024	C	C	152325024	2	2	86	1	0	0	0	0	0	0	0	1	5923	1654	58	4		4	FLG2	1	152325024	Silent	SNP	T	TCGA-06-5408-01A-01D-1696-08	66151524	152325024	96925597	4	5788											
F5	2153	broad.mit.edu	37	chr1	169484809	169484809	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccctgtgttataattgccGttatcttcttgatcttgagt	8	8	3	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr1:169484809G>A	uc001ggg.1	-	24	6546	c.6401C>T	c.(6400-6402)ACG>ATG	p.T2134M		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2134	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TATAATTGCCGTTATCTTCTT	0.388													A	169484809	A	A	169484809	3	1	86	1	0	0	0	0	1	0	0	0	5348	1145	40	1	281	1	F5	1	169484809	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	17159785	169484809	79765812	5	5789											
SELE	6401	broad.mit.edu	37	chr1	169698774	169698774	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggttttggaaacattccacGaacccattggctggatttgt	11	8	0	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr1:169698774G>A	uc001ggm.3	-	6	913	c.756C>T	c.(754-756)TTC>TTT	p.F252F	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	252	Sushi 2.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					AACATTCCACGAACCCATTGG	0.428													A	169698774	A	A	169698774	2	1	86	1	0	0	0	0	0	0	0	1	14013	1049	37	2		2	SELE	1	169698774	Silent	SNP	G	TCGA-06-5408-01A-01D-1696-08	213965	169698774	79551847	6	5790											
CAD	790	broad.mit.edu	37	chr2	27459352	27459352	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgctgacttctccgtgccCctaatcatcgatatcaagtg	8	14	3	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr2:27459352C>T	uc002rji.2	+	26	4437	c.4275C>T	c.(4273-4275)CCC>CCT	p.P1425P	CAD_uc010eyw.2_Silent_p.P1362P	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1425	CPSase B.|CPSase (Carbamoyl-phosphate synthase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TCTCCGTGCCCCTAATCATCG	0.557													T	27459352	T	T	27459352	2	4	86	1	0	0	0	0	0	0	0	1	2565	610	22	3		3	CAD	2	27459352	Silent	SNP	C	TCGA-06-5408-01A-01D-1696-08		27459352	215740021	7	5791											
STRN	6801	broad.mit.edu	37	chr2	37078198	37078198	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcatgagcagtgatgctgatCggaagagtaggatgactgat	14	5	1	6			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr2:37078198C>T	uc002rpn.2	-	16	2040	c.2031G>A	c.(2029-2031)CCG>CCA	p.P677P	STRN_uc010ezx.2_Silent_p.P640P	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	677	WD 4.			P -> S (in Ref. 1; CAA11560).	dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TGATGCTGATCGGAAGAGTAG	0.303													T	37078198	T	T	37078198	2	4	86	1	0	0	0	0	0	0	0	1	15328	871	31	2		2	STRN	2	37078198	Silent	SNP	C	TCGA-06-5408-01A-01D-1696-08	9618846	37078198	206121175	8	5792											
XIRP2	129446	broad.mit.edu	37	chr2	167760222	167760222	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtggagttcgaagccggaagAgaaggattctgtggacaaga	16	5	1	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr2:167760222A>G	uc002udx.2	+	1	248	c.230A>G	c.(229-231)GAG>GGG	p.E77G	XIRP2_uc010fpn.2_Missense_Mutation_p.E77G|XIRP2_uc010fpo.2_Missense_Mutation_p.E77G|XIRP2_uc010fpp.2_Missense_Mutation_p.E77G	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAGCCGGAAGAGAAGGATTCT	0.522													G	167760222	G	G	167760222	3	3	86	1	0	0	0	0	1	0	0	0	17427	304	11	4	232	4	XIRP2	2	167760222	Missense_Mutation	SNP	A	TCGA-06-5408-01A-01D-1696-08	130682024	167760222	75439151	9	5793											
TRAK2	66008	broad.mit.edu	37	chr2	202252532	202252532	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtgcagagagaggcaagGctctctgtcggggtgacaca	17	8	1	3			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr2:202252532G>A	uc002uyb.3	-	13	2036	c.1590C>T	c.(1588-1590)AGC>AGT	p.S530S		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	530				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0						GAGAGGCAAGGCTCTCTGTCG	0.512													A	202252532	A	A	202252532	2	1	86	1	0	0	0	0	0	0	0	1	16447	1194	42	3		3	TRAK2	2	202252532	Silent	SNP	G	TCGA-06-5408-01A-01D-1696-08	34492310	202252532	40946841	10	5794											
CXCR2	3579	broad.mit.edu	37	chr2	218999840	218999840	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaccttgcccatctgggccGcctccaaggtgaatggctgg	13	13	1	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr2:218999840G>A	uc002vgz.1	+	4	541	c.316G>A	c.(316-318)GCC>ACC	p.A106T	CXCR2_uc002vha.1_Missense_Mutation_p.A106T|CXCR2_uc002vhb.1_Missense_Mutation_p.A106T	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	106	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						CATCTGGGCCGCCTCCAAGGT	0.552													A	218999840	A	A	218999840	3	1	86	1	0	0	0	0	1	0	0	0	4091	1087	38	1	318	1	CXCR2	2	218999840	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	16747308	218999840	24199533	11	5795											
SCN10A	6336	broad.mit.edu	37	chr3	38770174	38770174	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaaagagtggaagaagtcGtgcatgtgccagcggggcca	17	7	0	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr3:38770174G>A	uc003ciq.2	-	15	2499	c.2499C>T	c.(2497-2499)CAC>CAT	p.H833H		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	833	II.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGAAGAAGTCGTGCATGTGCC	0.512													A	38770174	A	A	38770174	2	1	86	1	0	0	0	0	0	0	0	1	13912	1136	40	1		1	SCN10A	3	38770174	Silent	SNP	G	TCGA-06-5408-01A-01D-1696-08		38770174	159252256	12	5796											
CCR1	1230	broad.mit.edu	37	chr3	46245393	46245393	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcccgcaaggcaaacacggCgtggacgatggccaggtacc	14	13	0	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr3:46245393C>T	uc003cph.1	-	2	483	c.412G>A	c.(412-414)GCC>ACC	p.A138T	CCR3_uc003cpg.1_Intron	NM_001295	NP_001286	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	138	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			skin(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GCAAACACGGCGTGGACGATG	0.512													T	46245393	T	T	46245393	3	4	86	1	0	0	0	0	1	0	0	0	2939	768	27	1	659	1	CCR1	3	46245393	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	7475219	46245393	151777037	13	5797											
PRR23B	389151	broad.mit.edu	37	chr3	138739096	138739096	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcgcagaattccagctcgacGacgacgtcctccctgacagc	10	16	0	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr3:138739096G>A	uc003esy.1	-	1	673	c.408C>T	c.(406-408)GTC>GTT	p.V136V		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	136										breast(1)	1						CCAGCTCGACGACGACGTCCT	0.652													A	138739096	A	A	138739096	2	1	86	1	0	0	0	0	0	0	0	1	12595	1045	37	2		2	PRR23B	3	138739096	Silent	SNP	G	TCGA-06-5408-01A-01D-1696-08	92493703	138739096	59283334	14	5798											
MFSD7	84179	broad.mit.edu	37	chr4	680063	680063	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatgcgtagcacactcccgGcaaagttcagccacgcaccc	8	18	1	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr4:680063G>A	uc003gay.2	-	3	380	c.323C>T	c.(322-324)GCC>GTC	p.A108V	MFSD7_uc003gaw.2_5'Flank|MFSD7_uc003gax.2_Missense_Mutation_p.A108V|MFSD7_uc003gaz.2_Intron|MFSD7_uc003gba.2_Intron|MFSD7_uc003gbb.1_Missense_Mutation_p.A44V	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	108	Helical; (Potential).				transmembrane transport	integral to membrane					0						CACACTCCCGGCAAAGTTCAG	0.657													A	680063	A	A	680063	3	1	86	1	0	0	0	0	1	0	0	0	9537	1203	42	3	1388	3	MFSD7	4	680063	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08		680063	190474213	15	5799											
LPHN3	23284	broad.mit.edu	37	chr4	62598628	62598628	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagaactgataccctgactgAgtattcatccaaggatgact	8	10	1	5			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr4:62598628A>G	uc010ihh.2	+	5	724	c.551A>G	c.(550-552)GAG>GGG	p.E184G	LPHN3_uc003hcq.3_Missense_Mutation_p.E184G|LPHN3_uc010ihg.1_Missense_Mutation_p.E252G|LPHN3_uc003hcs.1_Missense_Mutation_p.E13G	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	184	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ACCCTGACTGAGTATTCATCC	0.493													G	62598628	G	G	62598628	3	3	86	1	0	0	0	0	1	0	0	0	8917	304	11	4	569	4	LPHN3	4	62598628	Missense_Mutation	SNP	A	TCGA-06-5408-01A-01D-1696-08	61918565	62598628	128555648	16	5800											
NHEDC2	133308	broad.mit.edu	37	chr4	103947532	103947532	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tctctcttttcacctctaaaCttgcacagaagtctctcctt	3	14	5	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr4:103947532C>G	uc003hwx.3	-	12	2481	c.1609G>C	c.(1609-1611)GTT>CTT	p.V537L	NHEDC2_uc010iln.1_Intron|NHEDC2_uc003hwy.2_Missense_Mutation_p.V537L|NHEDC2_uc011cew.1_Missense_Mutation_p.V480L|NHEDC2_uc011cex.1_3'UTR	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Na+/H+ exchanger domain containing 2	537					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity				0				OV - Ovarian serous cystadenocarcinoma(123;2.3e-08)		CACCTCTAAACTTGCACAGAA	0.353													G	103947532	G	G	103947532	3	3	86	1	0	0	0	0	1	0	0	0	10401	565	20	5	8	5	NHEDC2	4	103947532	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	41348904	103947532	87206744	17	5801											
CARD6	84674	broad.mit.edu	37	chr5	40852866	40852866	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaacacacttctcagccctGcccagttgaaattacacaaa	4	14	2	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr5:40852866G>A	uc003jmg.2	+	3	1507	c.1432G>A	c.(1432-1434)GCC>ACC	p.A478T		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	478					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						TCTCAGCCCTGCCCAGTTGAA	0.433													A	40852866	A	A	40852866	3	1	86	1	0	0	0	0	1	0	0	0	2650	1319	46	3	1442	3	CARD6	5	40852866	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08		40852866	140062394	18	5802											
ATOX1	475	broad.mit.edu	37	chr5	151125916	151125916	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaaggtaggaaacagtcttTcctgttttcttcagggttgc	10	9	3	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr5:151125916T>C	uc003luk.2	-	3	275	c.177A>G	c.(175-177)GGA>GGG	p.G59G		NM_004045	NP_004036	O00244	ATOX1_HUMAN	antioxidant protein 1	59	HMA.				cellular copper ion homeostasis|copper ion transport|response to oxidative stress	cytosol	copper chaperone activity|copper-dependent protein binding				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			AAACAGTCTTTCCTGTTTTCT	0.542													C	151125916	C	C	151125916	2	2	86	1	0	0	0	0	0	0	0	1	1115	1770	62	4		4	ATOX1	5	151125916	Silent	SNP	T	TCGA-06-5408-01A-01D-1696-08	110273050	151125916	29789344	19	5803											
MBOAT1	154141	broad.mit.edu	37	chr6	20118736	20118736	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cccattcttatccactccgcTgaacccaaagccagctgcgt	6	17	1	1	rs150163538		TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr6:20118736T>C	uc003ncx.1	-	9	1148	c.943A>G	c.(943-945)AGC>GGC	p.S315G	MBOAT1_uc011dji.1_Missense_Mutation_p.S166G	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain	315	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			TCCACTCCGCTGAACCCAAAG	0.393													C	20118736	C	C	20118736	3	2	86	1	0	0	0	0	1	0	0	0	9356	1580	55	4	564	4	MBOAT1	6	20118736	Missense_Mutation	SNP	T	TCGA-06-5408-01A-01D-1696-08		20118736	150996331	20	5804											
GRM4	2914	broad.mit.edu	37	chr6	34008523	34008523	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcctgcccaattcgctcacGgtctgcaatgaaacaccagg	8	14	2	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr6:34008523G>A	uc003oir.3	-	6	1341	c.1171C>T	c.(1171-1173)CGT>TGT	p.R391C	GRM4_uc011dsn.1_Missense_Mutation_p.R344C|GRM4_uc010jvh.2_Missense_Mutation_p.R391C|GRM4_uc010jvi.2_Missense_Mutation_p.R83C|GRM4_uc003oio.2_Missense_Mutation_p.R83C|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Missense_Mutation_p.R251C|GRM4_uc003oiq.2_Missense_Mutation_p.R258C|GRM4_uc011dsm.1_Missense_Mutation_p.R222C	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	391	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	ATTCGCTCACGGTCTGCAATG	0.597													A	34008523	A	A	34008523	3	1	86	1	0	0	0	0	1	0	0	0	6799	1116	39	2	1587	2	GRM4	6	34008523	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	13889787	34008523	137106544	21	5805											
VEGFA	7422	broad.mit.edu	37	chr6	43752359	43752359	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	accagatctctcaccaggaaAgactgatacagaacgatcga	8	11	2	4			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr6:43752359A>T	uc003owi.2	+	7	1601	c.1110A>T	c.(1108-1110)AAA>AAT	p.K370N	VEGFA_uc003owd.2_3'UTR|VEGFA_uc003owf.2_3'UTR|VEGFA_uc003owe.2_3'UTR|VEGFA_uc003owg.2_3'UTR|VEGFA_uc003owh.2_3'UTR|VEGFA_uc003owj.2_3'UTR|VEGFA_uc010jyx.2_3'UTR|VEGFA_uc003owk.2_RNA	NM_001033756	NP_001028928	P15692	VEGFA_HUMAN	vascular endothelial growth factor A isoform g	Error:Variant_position_missing_in_P15692_after_alignment					basophil chemotaxis|cellular response to hypoxia|induction of positive chemotaxis|induction of positive chemotaxis|platelet activation|platelet degranulation|platelet-derived growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of leukocyte migration|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular permeability|regulation of cell shape|vascular endothelial growth factor receptor signaling pathway|vasculogenesis	cell surface|extracellular space|membrane|platelet alpha granule lumen	cell surface binding|chemoattractant activity|cytokine activity|fibronectin binding|growth factor activity|heparin binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor binding			ovary(1)|breast(1)	2	all_cancers(18;5.46e-07)|all_epithelial(2;5.96e-08)|Lung NSC(15;0.000157)|all_lung(25;0.000486)|Hepatocellular(11;0.00309)		all cancers(41;0.000413)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0742)|OV - Ovarian serous cystadenocarcinoma(102;0.196)		Atorvastatin(DB01076)|Bevacizumab(DB00112)|Carvedilol(DB01136)|Ginkgo biloba(DB01381)|Gliclazide(DB01120)|Minocycline(DB01017)|Ranibizumab(DB01270)|Simvastatin(DB00641)	TCACCAGGAAAGACTGATACA	0.527													T	43752359	T	T	43752359	3	4	86	1	0	0	0	0	1	0	0	0	17147	69	3	5	1289	5	VEGFA	6	43752359	Missense_Mutation	SNP	A	TCGA-06-5408-01A-01D-1696-08	9743836	43752359	127362708	22	5806											
ZNF92	168374	broad.mit.edu	37	chr7	64864755	64864755	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggcagagcctttaacaaatcCtcaaattatactaaagagaa	6	8	1	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr7:64864755C>A	uc003ttz.2	+	4	1871	c.1728C>A	c.(1726-1728)TCC>TCA	p.S576S	ZNF92_uc003tua.2_Silent_p.S507S|ZNF92_uc010kzu.2_Silent_p.S544S|ZNF92_uc003tub.2_Silent_p.S500S	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	576	C2H2-type 16; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				TTAACAAATCCTCAAATTATA	0.348													A	64864755	A	A	64864755	2	1	86	1	0	0	0	0	0	0	0	1	18198	668	24	5		5	ZNF92	7	64864755	Silent	SNP	C	TCGA-06-5408-01A-01D-1696-08		64864755	94273908	23	5807											
MTERF	7978	broad.mit.edu	37	chr7	91503564	91503564	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caatccaactgagtagaggaActttatattattctctaagt	6	7	1	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr7:91503564A>G	uc003ulb.1	-	2	588	c.544T>C	c.(544-546)TTC>CTC	p.F182L	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Missense_Mutation_p.F182L|MTERF_uc011khm.1_Missense_Mutation_p.F162L|MTERF_uc010leu.1_Missense_Mutation_p.F162L	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	182					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			GAGTAGAGGAACTTTATATTA	0.378													G	91503564	G	G	91503564	3	3	86	1	0	0	0	0	1	0	0	0	9918	43	2	4	659	4	MTERF	7	91503564	Missense_Mutation	SNP	A	TCGA-06-5408-01A-01D-1696-08	26638809	91503564	67635099	24	5808											
CCDC132	55610	broad.mit.edu	37	chr7	92883220	92883220	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaattagaggcgtatagagaCaaattgaaacaacagcaagc	10	6	0	3			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr7:92883220C>G	uc003umo.2	+	4	401	c.273C>G	c.(271-273)GAC>GAG	p.D91E	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.D61E|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Missense_Mutation_p.D91E	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	91	Potential.										0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			CGTATAGAGACAAATTGAAAC	0.323													G	92883220	G	G	92883220	3	3	86	1	0	0	0	0	1	0	0	0	2767	477	17	5	287	5	CCDC132	7	92883220	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	1379656	92883220	66255443	25	5809											
WNT2	7472	broad.mit.edu	37	chr7	116960744	116960744	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacgccctggctaatggcacGcatcacatctggatgtcggt	11	13	2	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr7:116960744G>A	uc003viz.2	-	2	487	c.187C>T	c.(187-189)CGT>TGT	p.R63C	WNT2_uc003vja.2_5'UTR	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	63					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CTAATGGCACGCATCACATCT	0.607													A	116960744	A	A	116960744	3	1	86	1	0	0	0	0	1	0	0	0	17383	1087	38	1	911	1	WNT2	7	116960744	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	24077524	116960744	42177919	26	5810											
UBN2	254048	broad.mit.edu	37	chr7	138978177	138978177	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacaaccacctcgggatctaCctcagccgctttccaccata	6	17	2	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr7:138978177C>T	uc011kqr.1	+	16	3869	c.3869C>T	c.(3868-3870)ACC>ATC	p.T1290I		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1290										ovary(1)|skin(1)	2						TCGGGATCTACCTCAGCCGCT	0.502													T	138978177	T	T	138978177	3	4	86	1	0	0	0	0	1	0	0	0	16890	507	18	3	3931	3	UBN2	7	138978177	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	22017433	138978177	20160486	27	5811											
KEL	3792	broad.mit.edu	37	chr7	142651272	142651272	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcccccagttccaggcaccTtgagctggtcgatagtgacc	12	14	0	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr7:142651272T>C	uc003wcb.2	-	8	1133	c.923A>G	c.(922-924)AAG>AGG	p.K308R		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	308	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TCCAGGCACCTTGAGCTGGTC	0.547													C	142651272	C	C	142651272	3	2	86	1	0	0	0	0	1	0	0	0	8142	1623	56	4	1323	4	KEL	7	142651272	Missense_Mutation	SNP	T	TCGA-06-5408-01A-01D-1696-08	3673095	142651272	16487391	28	5812											
XKR4	114786	broad.mit.edu	37	chr8	56436491	56436491	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acggtccatctccaacaaccGcagtgttgtcagcgaccgcg	10	15	2	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr8:56436491G>A	uc003xsf.2	+	3	1690	c.1658G>A	c.(1657-1659)CGC>CAC	p.R553H		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	553						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TCCAACAACCGCAGTGTTGTC	0.592													A	56436491	A	A	56436491	3	1	86	1	0	0	0	0	1	0	0	0	17430	1087	38	1	1668	1	XKR4	8	56436491	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08		56436491	89927531	29	5813											
JPH1	56704	broad.mit.edu	37	chr8	75171693	75171693	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactcctggcgagcggccagCgcggcctggtcggcggcatc	16	16	0	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr8:75171693C>T	uc003yae.2	-	3	1225	c.1185G>A	c.(1183-1185)GCG>GCA	p.A395A	JPH1_uc003yaf.2_Silent_p.A395A|JPH1_uc003yag.1_Silent_p.A259A	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	395	Ala-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GAGCGGCCAGCGCGGCCTGGT	0.592													T	75171693	T	T	75171693	2	4	86	1	0	0	0	0	0	0	0	1	7960	755	27	1		1	JPH1	8	75171693	Silent	SNP	C	TCGA-06-5408-01A-01D-1696-08	18735202	75171693	71192329	30	5814											
GEM	2669	broad.mit.edu	37	chr8	95262754	95262754	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacagctccttcacgttgtgCtggacagctgcagaggtctc	11	12	2	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr8:95262754C>T	uc003ygj.2	-	5	924	c.675G>A	c.(673-675)CAG>CAA	p.Q225Q	GEM_uc003ygi.2_Silent_p.Q225Q	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	225					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			TCACGTTGTGCTGGACAGCTG	0.562													T	95262754	T	T	95262754	2	4	86	1	0	0	0	0	0	0	0	1	6329	796	28	3		3	GEM	8	95262754	Silent	SNP	C	TCGA-06-5408-01A-01D-1696-08	20091061	95262754	51101268	31	5815											
TTC18	118491	broad.mit.edu	37	chr10	75051125	75051125	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacttgtgcctgaagcatccGtgcctgaagctgtttggagg	13	9	0	2	rs141991496		TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr10:75051125G>A	uc009xrc.2	-	20	2429	c.2308C>T	c.(2308-2310)CGG>TGG	p.R770W	TTC18_uc001jty.2_Missense_Mutation_p.R770W|TTC18_uc001jtv.3_Translation_Start_Site|TTC18_uc001jtw.3_Translation_Start_Site|TTC18_uc001jtx.2_Missense_Mutation_p.R151W	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	770							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					TGAAGCATCCGTGCCTGAAGC	0.423													A	75051125	A	A	75051125	3	1	86	1	0	0	0	0	1	0	0	0	16682	1144	40	1	1093	1	TTC18	10	75051125	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08		75051125	60483622	32	5816											
MMP21	118856	broad.mit.edu	37	chr10	127462500	127462500	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccacatcctgaaggccagCgccacaatgcgccgctggtc	10	17	0	1	rs138636566		TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr10:127462500C>T	uc001liu.2	-	2	597	c.597G>A	c.(595-597)GCG>GCA	p.A199A		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	199					proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGAAGGCCAGCGCCACAATGC	0.701													T	127462500	T	T	127462500	2	4	86	1	0	0	0	0	0	0	0	1	9660	755	27	1		1	MMP21	10	127462500	Silent	SNP	C	TCGA-06-5408-01A-01D-1696-08	52411375	127462500	8072247	33	5817											
CNGA4	1262	broad.mit.edu	37	chr11	6261559	6261559	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatgctttacatttttgtcGtcatccattggaacagctgc	8	9	1	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr11:6261559G>A	uc001mco.2	+	4	642	c.535G>A	c.(535-537)GTC>ATC	p.V179I	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.V139I	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	179	Helical; Name=H4; (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATTTTTGTCGTCATCCATTG	0.597													A	6261559	A	A	6261559	3	1	86	1	0	0	0	0	1	0	0	0	3599	1145	40	1	549	1	CNGA4	11	6261559	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08		6261559	128744957	34	5818											
RAG2	5897	broad.mit.edu	37	chr11	36614338	36614338	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gatgagtgtgcgttctgccaGatccatgcactgagcatgga	13	9	1	3			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr11:36614338G>T	uc001mwv.3	-	2	1569	c.1381C>A	c.(1381-1383)CTG>ATG	p.L461M	RAG1_uc001mwt.2_Intron|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	461	PHD-type; atypical.				chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				CGTTCTGCCAGATCCATGCAC	0.498									Familial_Hemophagocytic_Lymphohistiocytosis				T	36614338	T	T	36614338	3	4	86	1	0	0	0	0	1	0	0	0	13005	933	33	5	206	5	RAG2	11	36614338	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	30352779	36614338	98392178	35	5819											
ACCS	84680	broad.mit.edu	37	chr11	44105037	44105037	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgctttttggacaacaagGtgctgctgtcctttggcaag	12	10	0	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr11:44105037G>A	uc009yks.1	+	14	1462	c.1318G>A	c.(1318-1320)GTG>ATG	p.V440M	EXT2_uc010rfo.1_Intron|ACCS_uc001mxx.2_Missense_Mutation_p.V440M	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	440							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						GGACAACAAGGTGCTGCTGTC	0.572													A	44105037	A	A	44105037	3	1	86	1	0	0	0	0	1	0	0	0	133	1261	44	3	1368	3	ACCS	11	44105037	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	7490699	44105037	90901479	36	5820											
OR5L2	26338	broad.mit.edu	37	chr11	55594870	55594870	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctctcggctccacacccccgTgtactttttcctcagccact	5	19	2	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr11:55594870T>A	uc001nhy.1	+	1	176	c.176T>A	c.(175-177)GTG>GAG	p.V59E		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CACACCCCCGTGTACTTTTTC	0.468										HNSCC(27;0.073)			A	55594870	A	A	55594870	3	1	86	1	0	0	0	0	1	0	0	0	11171	1696	59	5	178	5	OR5L2	11	55594870	Missense_Mutation	SNP	T	TCGA-06-5408-01A-01D-1696-08	11489833	55594870	79411646	37	5821											
SLC22A9	114571	broad.mit.edu	37	chr11	63174115	63174115	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actgaaatacatgaaccgtcGagcaagccagatgcttctca	8	11	1	3			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr11:63174115G>A	uc001nww.2	+	7	1488	c.1220G>A	c.(1219-1221)CGA>CAA	p.R407Q	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	407	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						ATGAACCGTCGAGCAAGCCAG	0.483													A	63174115	A	A	63174115	3	1	86	1	0	0	0	0	1	0	0	0	14461	1058	37	2	1246	2	SLC22A9	11	63174115	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	7579245	63174115	71832401	38	5822											
STYK1	55359	broad.mit.edu	37	chr12	10772903	10772903	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagctctctaggtgaggggCggtcagcctcacgccagcgc	15	14	3	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr12:10772903C>T	uc001qys.2	-	11	1630	c.1109G>A	c.(1108-1110)CGC>CAC	p.R370H		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	370	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						AGGTGAGGGGCGGTCAGCCTC	0.527										HNSCC(73;0.22)			T	10772903	T	T	10772903	3	4	86	1	0	0	0	0	1	0	0	0	15358	768	27	1	163	1	STYK1	12	10772903	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08		10772903	123078992	39	5823											
TMEM5	10329	broad.mit.edu	37	chr12	64202634	64202634	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctggcaactgtgggaataCatctgtgcaccacggtgctc	12	11	1	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr12:64202634C>T	uc001srq.1	+	6	1198	c.1094C>T	c.(1093-1095)ACA>ATA	p.T365I	TMEM5_uc001srr.1_Missense_Mutation_p.T262I|TMEM5_uc001srs.1_Missense_Mutation_p.T105I	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	365	Extracellular (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		TGTGGGAATACATCTGTGCAC	0.478													T	64202634	T	T	64202634	3	4	86	1	0	0	0	0	1	0	0	0	16171	478	17	3	1116	3	TMEM5	12	64202634	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	53429731	64202634	69649261	40	5824											
OAS2	4939	broad.mit.edu	37	chr12	113447011	113447011	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctctccctgcttcaaggatgGgactggaaacccaataccac	8	14	2	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr12:113447011G>T	uc001tuj.2	+	10	2155	c.2015G>T	c.(2014-2016)GGG>GTG	p.G672V	OAS2_uc001tui.1_Missense_Mutation_p.G672V	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	672	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						TTCAAGGATGGGACTGGAAAC	0.502													T	113447011	T	T	113447011	3	4	86	1	0	0	0	0	1	0	0	0	10800	1232	43	5	2124	5	OAS2	12	113447011	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	49244377	113447011	20404884	41	5825											
FREM2	341640	broad.mit.edu	37	chr13	39422735	39422735	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agaaatttgaactggtgcttCgcatgcctatgaacgcagcc	10	10	0	3			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr13:39422735C>T	uc001uwv.2	+	8	6616	c.6307C>T	c.(6307-6309)CGC>TGC	p.R2103C	FREM2_uc001uww.2_Missense_Mutation_p.R189C	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2103	Extracellular (Potential).|Calx-beta 3.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ACTGGTGCTTCGCATGCCTAT	0.463													T	39422735	T	T	39422735	3	4	86	1	0	0	0	0	1	0	0	0	6045	884	31	2	6337	2	FREM2	13	39422735	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08		39422735	75747143	42	5826											
MED4	29079	broad.mit.edu	37	chr13	48669208	48669208	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctcaccactcgaagacgCagccattttccccagagtcc	6	17	1	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr13:48669208C>T	uc001vby.1	-	1	33	c.7G>A	c.(7-9)GCG>ACG	p.A3T	MED4_uc010tge.1_Missense_Mutation_p.A3T|MED4_uc010tgf.1_5'UTR	NM_014166	NP_054885	Q9NPJ6	MED4_HUMAN	mediator complex subunit 4	3					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		all_cancers(8;2.93e-25)|all_epithelial(8;4.38e-13)|all_lung(13;7.37e-06)|all_hematologic(8;8.61e-05)|Breast(56;0.000141)|Lung NSC(96;0.000518)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.00559)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;5.18e-07)		CTCGAAGACGCAGCCATTTTC	0.662											OREG0022406	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	48669208	T	T	48669208	3	4	86	1	0	0	0	0	1	0	0	0	9450	710	25	3	833	3	MED4	13	48669208	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	9246473	48669208	66500670	43	5827											
ABCC4	10257	broad.mit.edu	37	chr13	95715015	95715015	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agtccaatttcagttgtcaaGatcttatcaatccaaatttt	4	8	4	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr13:95715015G>C	uc001vmd.3	-	26	3428	c.3309C>G	c.(3307-3309)ATC>ATG	p.I1103M	ABCC4_uc010afj.2_Translation_Start_Site|ABCC4_uc010afk.2_Missense_Mutation_p.I1056M	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	1103	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CAGTTGTCAAGATCTTATCAA	0.423													C	95715015	C	C	95715015	3	2	86	1	0	0	0	0	1	0	0	0	55	932	33	5	692	5	ABCC4	13	95715015	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	47045807	95715015	19454863	44	5828											
RTN1	6252	broad.mit.edu	37	chr14	60212584	60212584	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacagaaggttctatttccGtcagtgtgattttgacaggg	11	7	2	3			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr14:60212584G>A	uc001xen.1	-	2	1066	c.857C>T	c.(856-858)ACG>ATG	p.T286M		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	286					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TTCTATTTCCGTCAGTGTGAT	0.458													A	60212584	A	A	60212584	3	1	86	1	0	0	0	0	1	0	0	0	13725	1145	40	1	1570	1	RTN1	14	60212584	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08		60212584	47136956	45	5829											
C14orf68	283600	broad.mit.edu	37	chr14	100795869	100795869	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgttcgagaggagggacccCgggtccttttcaaggggctg	17	10	1	1	rs145556108	byFrequency	TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr14:100795869C>T	uc001yhc.2	+	6	887	c.814C>T	c.(814-816)CGG>TGG	p.R272W	C14orf68_uc001yhd.2_Missense_Mutation_p.R126W	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	272	Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				GGAGGGACCCCGGGTCCTTTT	0.637													T	100795869	T	T	100795869	3	4	86	1	0	0	0	0	1	0	0	0	1778	643	23	2	836	2	C14orf68	14	100795869	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	40583285	100795869	6553671	46	5830											
AHNAK2	113146	broad.mit.edu	37	chr14	105417146	105417146	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcctggacctccaggtcagCagaagggggctgtatgctca	14	11	2	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr14:105417146C>T	uc010axc.1	-	7	4762	c.4642G>A	c.(4642-4644)GCT>ACT	p.A1548T	AHNAK2_uc001ypx.2_Missense_Mutation_p.A1448T	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1548						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCCAGGTCAGCAGAAGGGGGC	0.642													T	105417146	T	T	105417146	3	4	86	1	0	0	0	0	1	0	0	0	415	710	25	3	12749	3	AHNAK2	14	105417146	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	4621277	105417146	1932394	47	5831											
ATP10A	57194	broad.mit.edu	37	chr15	25966826	25966827	+	Frame_Shift_Ins	INS	-	AC	AC													ttgcatcatgagaatattctINSacaccagacacagtgcatct							TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr15:25966826_25966827insAC	uc010ayu.2	-	7	1446_1447	c.1340_1341insGT	c.(1339-1341)GTAfs	p.V447fs		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	447	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GAGAATATTCTACACCAGACAC	0.446													AC	25966827	AC	AC	25966826	7	5	86	1	0	1	1	0	0	0	0	0	1116	1509	53	0	3218	0	ATP10A	15	25966826	Frame_Shift_Ins	INS	-	TCGA-06-5408-01A-01D-1696-08		25966826	76564566	48	5832											
CYP11A1	1583	broad.mit.edu	37	chr15	74635350	74635350	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgccagcatctctgtgaCgttggccttgatgtcctcga	10	13	1	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr15:74635350C>T	uc002axt.2	-	5	1113	c.958G>A	c.(958-960)GTC>ATC	p.V320I	CYP11A1_uc002axs.2_Missense_Mutation_p.V162I|CYP11A1_uc010bjm.1_Missense_Mutation_p.V162I|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Missense_Mutation_p.V320I|CYP11A1_uc010bjp.1_Intron|CYP11A1_uc010ulj.1_Missense_Mutation_p.V100I	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	320					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	ATCTCTGTGACGTTGGCCTTG	0.602													T	74635350	T	T	74635350	3	4	86	1	0	0	0	0	1	0	0	0	4144	536	19	1	627	1	CYP11A1	15	74635350	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	48668524	74635350	27896042	49	5833											
WDR90	197335	broad.mit.edu	37	chr16	703407	703407	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggtcatcgtcgtcctgctcGtggacacgggggagcagcgc	16	13	1	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr16:703407G>A	uc002cii.1	+	11	1243	c.1189G>A	c.(1189-1191)GTG>ATG	p.V397M	WDR90_uc002cig.1_Missense_Mutation_p.V397M|WDR90_uc002cih.1_Missense_Mutation_p.V398M|WDR90_uc002cij.1_RNA|WDR90_uc002cik.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	397										ovary(1)	1		Hepatocellular(780;0.0218)				CGTCCTGCTCGTGGACACGGG	0.701													A	703407	A	A	703407	3	1	86	1	0	0	0	0	1	0	0	0	17334	1145	40	1	1231	1	WDR90	16	703407	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08		703407	89651346	50	5834											
TMEM186	25880	broad.mit.edu	37	chr16	8890029	8890029	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaagttcagatgggccaccCgcagcatggtgccagactca	12	12	2	3			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr16:8890029C>T	uc002cze.2	-	2	456	c.422G>A	c.(421-423)CGG>CAG	p.R141Q	PMM2_uc002czf.3_5'Flank|PMM2_uc010uyf.1_5'Flank|PMM2_uc010uyg.1_5'Flank|PMM2_uc010uyh.1_5'Flank|PMM2_uc010buj.2_5'Flank|PMM2_uc010uyi.1_5'Flank|PMM2_uc010uye.1_5'Flank	NM_015421	NP_056236	Q96B77	TM186_HUMAN	transmembrane protein 186	141						integral to membrane|mitochondrion				ovary(1)	1						ATGGGCCACCCGCAGCATGGT	0.557													T	8890029	T	T	8890029	3	4	86	1	0	0	0	0	1	0	0	0	16105	652	23	2	223	2	TMEM186	16	8890029	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08	8186622	8890029	81464724	51	5835											
MMP2	4313	broad.mit.edu	37	chr16	55525753	55525753	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcccacgagtttggccaCgccatggggctggagcactc	14	14	0	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr16:55525753C>T	uc002ehz.3	+	8	1532	c.1221C>T	c.(1219-1221)CAC>CAT	p.H407H	MMP2_uc010vhd.1_Silent_p.H331H|MMP2_uc010ccc.2_Silent_p.H357H|MMP2_uc002eia.3_5'Flank	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	407	Collagenase-like 2.	Zinc 2; catalytic (By similarity).			angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	AGTTTGGCCACGCCATGGGGC	0.577													T	55525753	T	T	55525753	2	4	86	1	0	0	0	0	0	0	0	1	9658	535	19	1		1	MMP2	16	55525753	Silent	SNP	C	TCGA-06-5408-01A-01D-1696-08	46635724	55525753	34829000	52	5836											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	8	15	1	0	rs28934576	by1000genomes	TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577120	T	T	7577120	3	4	86	1	0	0	0	0	1	0	0	0	16378	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-06-5408-01A-01D-1696-08		7577120	73618090	53	5837											
GAS7	8522	broad.mit.edu	37	chr17	9822945	9822945	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acatccctgcccgcttaccaAtgtggtggtcaccatctctt	7	15	2	0			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr17:9822945A>G	uc002gmg.1	-	12	1377	c.1216T>C	c.(1216-1218)TTG>CTG	p.L406L	GAS7_uc010vvc.1_Silent_p.L220L|GAS7_uc002gmh.1_Silent_p.L266L|GAS7_uc010vvd.1_Silent_p.L358L|GAS7_uc002gmi.2_Silent_p.L342L|GAS7_uc002gmj.1_Silent_p.L346L|GAS7_uc010coh.1_Silent_p.L346L	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	406	Potential.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						CCGCTTACCAATGTGGTGGTC	0.567			T	MLL	AML*								G	9822945	G	G	9822945	2	3	86	1	0	0	0	0	0	0	0	1	6250	98	4	4		4	GAS7	17	9822945	Silent	SNP	A	TCGA-06-5408-01A-01D-1696-08	2245825	9822945	71372265	54	5838											
NF1	4763	broad.mit.edu	37	chr17	29587504	29587504	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctactctggaacaatcaggaGaaaattgggcagtatctttc	9	8	3	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr17:29587504G>A	uc002hgg.2	+	34	4881	c.4548G>A	c.(4546-4548)GAG>GAA	p.E1516E	NF1_uc002hgh.2_Silent_p.E1495E|NF1_uc002hgi.1_Silent_p.E528E	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1516					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(3)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ACAATCAGGAGAAAATTGGGC	0.388			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29587504	A	A	29587504	2	1	86	1	0	0	0	0	0	0	0	1	10356	933	33	3		3	NF1	17	29587504	Silent	SNP	G	TCGA-06-5408-01A-01D-1696-08	19764559	29587504	51607706	55	5839											
KRT9	3857	broad.mit.edu	37	chr17	39724810	39724810	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caactcctggacaccgtgccGgagctgggtcacctccttgg	12	15	1	0	rs116216460	byFrequency	TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr17:39724810G>A	uc002hxe.3	-	5	1186	c.1120C>T	c.(1120-1122)CGG>TGG	p.R374W	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	374	Rod.|Coil 2.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				ACACCGTGCCGGAGCTGGGTC	0.547													A	39724810	A	A	39724810	3	1	86	1	0	0	0	0	1	0	0	0	8501	1115	39	2	763	2	KRT9	17	39724810	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	10137306	39724810	41470400	56	5840											
MUC16	94025	broad.mit.edu	37	chr19	9088857	9088857	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gagagagaagtggcagaggtTgaaacagtggttgttgctga	17	3	0	5			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr19:9088857T>A	uc002mkp.2	-	1	3162	c.2958A>T	c.(2956-2958)TCA>TCT	p.S986S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	986	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGCAGAGGTTGAAACAGTGG	0.463													A	9088857	A	A	9088857	2	1	86	1	0	0	0	0	0	0	0	1	9973	1799	63	5		5	MUC16	19	9088857	Silent	SNP	T	TCGA-06-5408-01A-01D-1696-08		9088857	50040126	57	5841											
CYP4F12	66002	broad.mit.edu	37	chr19	15791225	15791225	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagggatactgctgagtggcGgtgacaagtggagccgccac	16	9	0	2			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr19:15791225G>A	uc002nbl.2	+	5	482	c.421G>A	c.(421-423)GGT>AGT	p.G141S	CYP4F12_uc010xoo.1_Missense_Mutation_p.G141S|CYP4F12_uc010xop.1_Missense_Mutation_p.R172Q	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GCTGAGTGGCGGTGACAAGTG	0.552													A	15791225	A	A	15791225	3	1	86	1	0	0	0	0	1	0	0	0	4187	1116	39	2	435	2	CYP4F12	19	15791225	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	6702368	15791225	43337758	58	5842											
SLC5A4	6527	broad.mit.edu	37	chr22	32634986	32634986	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acttaccagtggtggtgtaaAcagcagtcatagccaagagg	12	8	1	1			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr22:32634986A>G	uc003ami.2	-	6	571	c.569T>C	c.(568-570)GTT>GCT	p.V190A		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	190	Helical; (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						GGTGGTGTAAACAGCAGTCAT	0.448													G	32634986	G	G	32634986	3	3	86	1	0	0	0	0	1	0	0	0	14667	43	2	4	1450	4	SLC5A4	22	32634986	Missense_Mutation	SNP	A	TCGA-06-5408-01A-01D-1696-08		32634986	18669580	59	5843											
DNAJB7	150353	broad.mit.edu	37	chr22	41257669	41257669	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcaagcgagtcttcaaagaaGtgaaaagaaaatggatccct	9	7	3	3			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chr22:41257669G>T	uc003azj.2	-	1	462	c.330C>A	c.(328-330)CAC>CAA	p.H110Q	XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azh.2_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_5'Flank|XPNPEP3_uc003azg.1_RNA|XPNPEP3_uc003azf.1_RNA|XPNPEP3_uc010gyh.1_5'Flank	NM_145174	NP_660157	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	110					protein folding		heat shock protein binding|unfolded protein binding	p.H110Q(1)		ovary(1)	1						CTTCAAAGAAGTGAAAAGAAA	0.388													T	41257669	T	T	41257669	3	4	86	1	0	0	0	0	1	0	0	0	4625	1020	36	5	603	5	DNAJB7	22	41257669	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08	8622683	41257669	10046897	60	5844											
MST4	51765	broad.mit.edu	37	chrX	131205232	131205232	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtgatgatgaatctgattccGagggctctgattcgtatgta	12	6	2	5			TCGA-06-5408-01A-01D-1696-08	TCGA-06-5408-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	ed8ca267-0153-475b-9154-361af62ff767	c32ea847-5a65-471c-a41b-6eecc1dc8242	g.chrX:131205232G>A	uc004ewk.1	+	8	1220	c.919G>A	c.(919-921)GAG>AAG	p.E307K	MST4_uc004ewl.1_Missense_Mutation_p.E230K|MST4_uc011mux.1_Missense_Mutation_p.E329K|MST4_uc010nrj.1_Missense_Mutation_p.E307K|MST4_uc004ewm.1_Missense_Mutation_p.E245K	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	307					cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					ATCTGATTCCGAGGGCTCTGA	0.348													A	131205232	A	A	131205232	3	1	86	1	0	0	0	0	1	0	0	0	9892	1059	37	2	945	2	MST4	23	131205232	Missense_Mutation	SNP	G	TCGA-06-5408-01A-01D-1696-08		131205232	24065328	61	5845											
C1orf112	55732	broad.mit.edu	37	chr1	169772375	169772375	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctgtgccacacaggaatcCatcattttggaaaatattca	6	9	3	0			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr1:169772375C>T	uc001ggp.2	+	6	547	c.237C>T	c.(235-237)TCC>TCT	p.S79S	C1orf112_uc001ggj.2_RNA|C1orf112_uc001ggo.2_Silent_p.S79S|C1orf112_uc001ggq.2_Silent_p.S79S|C1orf112_uc009wvt.2_5'UTR|C1orf112_uc010plu.1_Silent_p.S50S|C1orf112_uc009wvu.1_Silent_p.S50S|C1orf112_uc001ggr.2_5'UTR|C1orf112_uc010plv.1_Silent_p.S21S	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	hypothetical protein LOC55732	79											0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CACAGGAATCCATCATTTTGG	0.363													T	169772375	T	T	169772375	2	4	87	1	0	0	0	0	0	0	0	1	1985	581	21	3		3	C1orf112	1	169772375	Silent	SNP	C	TCGA-06-5410-01A-01D-1696-08		169772375	79478246	1	5846											
LY75	4065	broad.mit.edu	37	chr2	160755280	160755280	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttgagattgctgtgccatGtccatccttcagagccagcc	9	12	1	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr2:160755280G>A	uc002ubc.3	-	2	454	c.385C>T	c.(385-387)CAT>TAT	p.H129Y	LY75_uc002ubb.3_Missense_Mutation_p.H129Y|LY75_uc010fos.2_Missense_Mutation_p.H129Y|LY75_uc010fot.1_Missense_Mutation_p.H129Y	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	129	Extracellular (Potential).|Ricin B-type lectin.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		GCTGTGCCATGTCCATCCTTC	0.522													A	160755280	A	A	160755280	3	1	87	1	0	0	0	0	1	0	0	0	9099	1377	48	3	4919	3	LY75	2	160755280	Missense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08		160755280	82444093	2	5847											
SI	6476	broad.mit.edu	37	chr3	164786544	164786544	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gattgggtgtctgattttgaGttgtgaagagaacactgttg	14	3	1	4			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr3:164786544G>T	uc003fei.2	-	5	511	c.449C>A	c.(448-450)ACT>AAT	p.T150N		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	150	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTGATTTTGAGTTGTGAAGAG	0.323										HNSCC(35;0.089)			T	164786544	T	T	164786544	3	4	87	1	0	0	0	0	1	0	0	0	14297	1029	36	5	5210	5	SI	3	164786544	Missense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08		164786544	33235886	3	5848											
PYDC2	152138	broad.mit.edu	37	chr3	191179074	191179074	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggaaaggagctacagacCgtcccccagacagaggtaga	13	11	0	4	rs141891926	by1000genomes	TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr3:191179074C>T	uc011bso.1	+	1	123	c.123C>T	c.(121-123)ACC>ACT	p.T41T		NM_001083308	NP_001076777	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	41	DAPIN.					cytoplasm|nucleus					0						AGCTACAGACCGTCCCCCAGA	0.542													T	191179074	T	T	191179074	2	4	87	1	0	0	0	0	0	0	0	1	12859	639	23	2		2	PYDC2	3	191179074	Silent	SNP	C	TCGA-06-5410-01A-01D-1696-08	26392530	191179074	6843356	4	5849											
KLHL5	51088	broad.mit.edu	37	chr4	39116788	39116788	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttttcttacagatatgatccCaaaacagacatgtggactgc	7	9	1	3			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr4:39116788C>G	uc003gts.2	+	10	2124	c.2049C>G	c.(2047-2049)CCC>CCG	p.P683P	KLHL5_uc003gtp.2_Silent_p.P637P|KLHL5_uc003gtq.2_Silent_p.P496P|KLHL5_uc003gtr.1_Silent_p.P683P|KLHL5_uc003gtt.2_Silent_p.P622P	NM_015990	NP_057074	Q96PQ7	KLHL5_HUMAN	kelch-like 5 isoform 1	683	Kelch 5.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1						GATATGATCCCAAAACAGACA	0.383													G	39116788	G	G	39116788	2	3	87	1	0	0	0	0	0	0	0	1	8392	581	21	5		5	KLHL5	4	39116788	Silent	SNP	C	TCGA-06-5410-01A-01D-1696-08		39116788	152037488	5	5850											
GPRIN3	285513	broad.mit.edu	37	chr4	90170302	90170302	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcgccactgcctgcacctcCgcatcttgccaagccctgct	7	20	1	0	rs145721148	byFrequency	TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr4:90170302C>T	uc003hsm.1	-	2	1479	c.960G>A	c.(958-960)GCG>GCA	p.A320A		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	320										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		CCTGCACCTCCGCATCTTGCC	0.537													T	90170302	T	T	90170302	2	4	87	1	0	0	0	0	0	0	0	1	6731	639	23	2		2	GPRIN3	4	90170302	Silent	SNP	C	TCGA-06-5410-01A-01D-1696-08	51053514	90170302	100983974	6	5851											
HEATR7B2	133558	broad.mit.edu	37	chr5	41048449	41048449	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagaggctgcagaagctcaGgtaaacgtgttttccatagg	12	9	1	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr5:41048449G>A	uc003jmj.3	-	16	2151	c.1661C>T	c.(1660-1662)CCT>CTT	p.P554L	HEATR7B2_uc003jmi.3_Missense_Mutation_p.P109L	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	554	HEAT 6.						binding			ovary(6)|central_nervous_system(2)	8						CAGAAGCTCAGGTAAACGTGT	0.468													A	41048449	A	A	41048449	3	1	87	1	0	0	0	0	1	0	0	0	7035	1000	35	3	3204	3	HEATR7B2	5	41048449	Missense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08		41048449	139866811	7	5852											
KCTD16	57528	broad.mit.edu	37	chr5	143853547	143853547	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagcaaaaaaaaagctgttaAagaaaagctctcaattgagg	8	6	1	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr5:143853547A>C	uc003lnm.1	+	4	1786	c.1157A>C	c.(1156-1158)AAA>ACA	p.K386T	KCTD16_uc003lnn.1_Missense_Mutation_p.K386T	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	386						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			AAAGCTGTTAAAGAAAAGCTC	0.443													C	143853547	C	C	143853547	3	2	87	1	0	0	0	0	1	0	0	0	8103	14	1	5	1163	5	KCTD16	5	143853547	Missense_Mutation	SNP	A	TCGA-06-5410-01A-01D-1696-08	102805098	143853547	37061713	8	5853											
UNC5A	90249	broad.mit.edu	37	chr5	176301527	176301527	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcaacatgacctatgggacCttcaacttcctcgggggccg	11	13	1	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr5:176301527C>T	uc003mey.2	+	8	1530	c.1338C>T	c.(1336-1338)ACC>ACT	p.T446T	UNC5A_uc010jkg.1_Silent_p.T406T	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	446	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTATGGGACCTTCAACTTCC	0.627													T	176301527	T	T	176301527	2	4	87	1	0	0	0	0	0	0	0	1	16988	668	24	3		3	UNC5A	5	176301527	Silent	SNP	C	TCGA-06-5410-01A-01D-1696-08	32447980	176301527	4613733	9	5854											
GRM3	2913	broad.mit.edu	37	chr7	86469103	86469103	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgtgtacgccttcaaaaCgcggaagtgcccagaaaatt	9	11	1	1	rs141671463		TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr7:86469103C>T	uc003uid.2	+	4	3372	c.2273C>T	c.(2272-2274)ACG>ATG	p.T758M	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.T630M|GRM3_uc010leh.2_Missense_Mutation_p.T350M	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	758	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane		p.T758M(1)		lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCCTTCAAAACGCGGAAGTGC	0.428													T	86469103	T	T	86469103	3	4	87	1	0	0	0	0	1	0	0	0	6798	536	19	1	2283	1	GRM3	7	86469103	Missense_Mutation	SNP	C	TCGA-06-5410-01A-01D-1696-08		86469103	72669560	10	5855											
CYP3A5	1577	broad.mit.edu	37	chr7	99262902	99262902	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgttcactccaaatgatgtgCcagtaatcacatccatgctg	7	11	2	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr7:99262902C>G	uc003urq.2	-	7	644	c.557G>C	c.(556-558)GGC>GCC	p.G186A	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Missense_Mutation_p.G6A|CYP3A5_uc003urr.2_Missense_Mutation_p.G73A|CYP3A5_uc011kiy.1_Missense_Mutation_p.G176A|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	186					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	AAATGATGTGCCAGTAATCAC	0.418													G	99262902	G	G	99262902	3	3	87	1	0	0	0	0	1	0	0	0	4180	739	26	5	979	5	CYP3A5	7	99262902	Missense_Mutation	SNP	C	TCGA-06-5410-01A-01D-1696-08	12793799	99262902	59875761	11	5856											
PIP	5304	broad.mit.edu	37	chr7	142836647	142836647	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccgtcgttgatgttattcGggaattaggcatctgccctg	12	9	1	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr7:142836647G>A	uc003wcf.1	+	4	389	c.353G>A	c.(352-354)CGG>CAG	p.R118Q		NM_002652	NP_002643	P12273	PIP_HUMAN	prolactin-induced protein precursor	118						extracellular region	actin binding			ovary(1)	1	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		GATGTTATTCGGGAATTAGGC	0.453													A	142836647	A	A	142836647	3	1	87	1	0	0	0	0	1	0	0	0	11935	1116	39	2	367	2	PIP	7	142836647	Missense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08	43573745	142836647	16302016	12	5857											
DMRT3	58524	broad.mit.edu	37	chr9	990484	990484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggagcagagcgaacttccGcagaacctgagagtctagcg	14	11	1	3			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr9:990484G>A	uc003zgw.1	+	2	936	c.898G>A	c.(898-900)GCA>ACA	p.A300T		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	300					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GCGAACTTCCGCAGAACCTGA	0.582													A	990484	A	A	990484	3	1	87	1	0	0	0	0	1	0	0	0	4587	1087	38	1	904	1	DMRT3	9	990484	Missense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08		990484	140222947	13	5858											
DLG5	9231	broad.mit.edu	37	chr10	79566617	79566617	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccctggggtaaggtgtcatcCacgtagaggatgtcgtcctt	13	10	1	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr10:79566617C>A	uc001jzk.2	-	26	4936	c.4866G>T	c.(4864-4866)GTG>GTT	p.V1622V	DLG5_uc001jzi.2_Silent_p.V377V|DLG5_uc001jzj.2_Silent_p.V1037V|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1622	SH3.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			AGGTGTCATCCACGTAGAGGA	0.572													A	79566617	A	A	79566617	2	1	87	1	0	0	0	0	0	0	0	1	4558	581	21	5		5	DLG5	10	79566617	Silent	SNP	C	TCGA-06-5410-01A-01D-1696-08		79566617	55968130	14	5859											
OR8H2	390151	broad.mit.edu	37	chr11	55873242	55873242	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaaagctttctctacttgcGtctctcatctcttgggagtc	8	11	4	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr11:55873242G>A	uc010riy.1	+	1	724	c.724G>A	c.(724-726)GTC>ATC	p.V242I		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CTCTACTTGCGTCTCTCATCT	0.383										HNSCC(53;0.14)			A	55873242	A	A	55873242	3	1	87	1	0	0	0	0	1	0	0	0	11238	1145	40	1	726	1	OR8H2	11	55873242	Missense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08		55873242	79133274	15	5860											
GLYATL2	219970	broad.mit.edu	37	chr11	58602091	58602091	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacatgttgccttggtgtctGtatttggggacagtataacc	11	7	1	0			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr11:58602091G>A	uc001nnd.3	-	6	827	c.696C>T	c.(694-696)TAC>TAT	p.Y232Y	GLYATL2_uc009ymq.2_Silent_p.Y232Y	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	232						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	CTTGGTGTCTGTATTTGGGGA	0.413													A	58602091	A	A	58602091	2	1	87	1	0	0	0	0	0	0	0	1	6481	1372	48	3		3	GLYATL2	11	58602091	Silent	SNP	G	TCGA-06-5410-01A-01D-1696-08	2728849	58602091	76404425	16	5861											
CTTN	2017	broad.mit.edu	37	chr11	70279266	70279266	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgtgagtgggacggagccGgagcccgtgtacagcatgga	17	10	0	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr11:70279266G>A	uc001opv.3	+	16	1532	c.1326G>A	c.(1324-1326)CCG>CCA	p.P442P	CTTN_uc001opu.2_Silent_p.P405P|CTTN_uc001opw.3_Silent_p.P405P|CTTN_uc010rqm.1_Silent_p.P126P|CTTN_uc001opx.2_Silent_p.P126P	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	442						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GGACGGAGCCGGAGCCCGTGT	0.652													A	70279266	A	A	70279266	2	1	87	1	0	0	0	0	0	0	0	1	4044	1103	39	2		2	CTTN	11	70279266	Silent	SNP	G	TCGA-06-5410-01A-01D-1696-08	11677175	70279266	64727250	17	5862											
DYNC2H1	79659	broad.mit.edu	37	chr11	103014114	103014114	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taaaggggaaagaagtagaaCgacttccaaggtattggagg	14	4	0	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr11:103014114C>T	uc001pho.2	+	18	2836	c.2692C>T	c.(2692-2694)CGA>TGA	p.R898*	DYNC2H1_uc001phn.1_Nonsense_Mutation_p.R898*|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	898	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGAAGTAGAACGACTTCCAAG	0.363													T	103014114	T	T	103014114	4	4	87	1	0	0	0	0	0	1	0	0	4846	528	19	1	2762	1	DYNC2H1	11	103014114	Nonsense_Mutation	SNP	C	TCGA-06-5410-01A-01D-1696-08	32734848	103014114	31992402	18	5863											
BCL2L14	79370	broad.mit.edu	37	chr12	12232401	12232401	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgagaacaagaagtttgtcCcagaggggcctggggaattg	15	7	0	3			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr12:12232401C>T	uc001rac.2	+	2	363	c.162C>T	c.(160-162)TCC>TCT	p.S54S	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_RNA|BCL2L14_uc001rad.2_Silent_p.S54S|BCL2L14_uc001rae.2_Silent_p.S54S	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	54					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding	p.S54S(1)		skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		GAAGTTTGTCCCAGAGGGGCC	0.488													T	12232401	T	T	12232401	2	4	87	1	0	0	0	0	0	0	0	1	1372	610	22	3		3	BCL2L14	12	12232401	Silent	SNP	C	TCGA-06-5410-01A-01D-1696-08		12232401	121619494	19	5864											
LIMA1	51474	broad.mit.edu	37	chr12	50575756	50575756	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgctggttggccaagagaCgctccattggatagactgtc	12	11	0	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr12:50575756C>T	uc001rwj.3	-	10	1379	c.1205G>A	c.(1204-1206)CGT>CAT	p.R402H	LIMA1_uc001rwg.3_Missense_Mutation_p.R100H|LIMA1_uc001rwh.3_Missense_Mutation_p.R241H|LIMA1_uc001rwi.3_Missense_Mutation_p.R243H|LIMA1_uc001rwk.3_Missense_Mutation_p.R403H|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	402	LIM zinc-binding.				actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						GGCCAAGAGACGCTCCATTGG	0.473													T	50575756	T	T	50575756	3	4	87	1	0	0	0	0	1	0	0	0	8796	536	19	1	1082	1	LIMA1	12	50575756	Missense_Mutation	SNP	C	TCGA-06-5410-01A-01D-1696-08	38343355	50575756	83276139	20	5865											
DGKA	1606	broad.mit.edu	37	chr12	56330335	56330335	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccagtgattttgcccagctGcaaaaatacatggaatgtga	9	9	0	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr12:56330335G>A	uc001sij.2	+	2	312	c.48G>A	c.(46-48)CTG>CTA	p.L16L	DGKA_uc009zoc.1_Silent_p.L16L|DGKA_uc001sih.1_5'UTR|DGKA_uc001sii.1_5'UTR|DGKA_uc009zod.1_Silent_p.L16L|DGKA_uc009zoe.1_Silent_p.L16L|DGKA_uc001sik.2_Silent_p.L16L|DGKA_uc001sil.2_Silent_p.L16L|DGKA_uc001sim.2_Silent_p.L16L|DGKA_uc001sin.2_Silent_p.L16L|DGKA_uc009zof.2_5'UTR|DGKA_uc001sio.2_5'UTR	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	16					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	TTGCCCAGCTGCAAAAATACA	0.527													A	56330335	A	A	56330335	2	1	87	1	0	0	0	0	0	0	0	1	4465	1306	46	3		3	DGKA	12	56330335	Silent	SNP	G	TCGA-06-5410-01A-01D-1696-08	5754579	56330335	77521560	21	5866											
FREM2	341640	broad.mit.edu	37	chr13	39266205	39266205	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaattcactatcacccaggTgcctattcatggccatctcc	6	14	4	0			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr13:39266205T>G	uc001uwv.2	+	1	5033	c.4724T>G	c.(4723-4725)GTG>GGG	p.V1575G		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1575	Extracellular (Potential).|CSPG 11.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ATCACCCAGGTGCCTATTCAT	0.418													G	39266205	G	G	39266205	3	3	87	1	0	0	0	0	1	0	0	0	6045	1696	59	5	4726	5	FREM2	13	39266205	Missense_Mutation	SNP	T	TCGA-06-5410-01A-01D-1696-08		39266205	75903673	22	5867											
CHD8	57680	broad.mit.edu	37	chr14	21871325	21871325	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagcggtcaatggcagcctGtcgaaggttgcctctaactc	12	11	2	0			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr14:21871325G>A	uc001was.1	-	18	2822	c.2728C>T	c.(2728-2730)CAG>TAG	p.Q910*	CHD8_uc001war.1_Nonsense_Mutation_p.Q806*|CHD8_uc001wav.1_Nonsense_Mutation_p.Q352*	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1189	Helicase C-terminal.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ATGGCAGCCTGTCGAAGGTTG	0.478													A	21871325	A	A	21871325	4	1	87	1	0	0	0	0	0	1	0	0	3331	1386	48	3	4264	3	CHD8	14	21871325	Nonsense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08		21871325	85478215	23	5868											
LRFN5	145581	broad.mit.edu	37	chr14	42360496	42360496	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cttttctggtcaataatctgGctgctggaactatgtatgac	9	8	3	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr14:42360496G>C	uc001wvm.2	+	4	2627	c.1429G>C	c.(1429-1431)GCT>CCT	p.A477P	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	477	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CAATAATCTGGCTGCTGGAAC	0.403										HNSCC(30;0.082)			C	42360496	C	C	42360496	3	2	87	1	0	0	0	0	1	0	0	0	8941	1203	42	5	1435	5	LRFN5	14	42360496	Missense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08	20489171	42360496	64989044	24	5869											
ZNF263	10127	broad.mit.edu	37	chr16	3339555	3339555	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggattgggcgcctcccccagAgggtggaatggagcaggcct	17	11	0	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr16:3339555A>G	uc002cuq.2	+	6	1381	c.1049A>G	c.(1048-1050)GAG>GGG	p.E350G	ZNF263_uc010uww.1_5'UTR|ZNF263_uc002cur.2_5'UTR	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	350					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						CCTCCCCCAGAGGGTGGAATG	0.617													G	3339555	G	G	3339555	3	3	87	1	0	0	0	0	1	0	0	0	17800	304	11	4	1071	4	ZNF263	16	3339555	Missense_Mutation	SNP	A	TCGA-06-5410-01A-01D-1696-08		3339555	87015198	25	5870											
ADCY9	115	broad.mit.edu	37	chr16	4016471	4016471	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgccgtcctgggcctgcgCggtgttcagccctgacgccg	15	16	1	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr16:4016471C>T	uc002cvx.2	-	11	3906	c.3367G>A	c.(3367-3369)GCG>ACG	p.A1123T		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	1123	Guanylate cyclase 2.|Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						TGGGCCTGCGCGGTGTTCAGC	0.602													T	4016471	T	T	4016471	3	4	87	1	0	0	0	0	1	0	0	0	301	768	27	1	698	1	ADCY9	16	4016471	Missense_Mutation	SNP	C	TCGA-06-5410-01A-01D-1696-08	676916	4016471	86338282	26	5871											
NF1	4763	broad.mit.edu	37	chr17	29533304	29533304	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tgatgctgtgtattgtcactCggttgaacttcgaaatatgt	10	6	1	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr17:29533304C>A	uc002hgg.2	+	12	1640	c.1307C>A	c.(1306-1308)TCG>TAG	p.S436*	NF1_uc002hge.1_Nonsense_Mutation_p.S436*|NF1_uc002hgf.1_Nonsense_Mutation_p.S436*|NF1_uc002hgh.2_Nonsense_Mutation_p.S436*|NF1_uc010csn.1_Nonsense_Mutation_p.S296*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	436					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TATTGTCACTCGGTTGAACTT	0.413			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29533304	A	A	29533304	4	1	87	1	0	0	0	0	0	1	0	0	10356	893	31	5	1353	5	NF1	17	29533304	Nonsense_Mutation	SNP	C	TCGA-06-5410-01A-01D-1696-08		29533304	51661906	27	5872											
CYP4F11	57834	broad.mit.edu	37	chr19	16034748	16034748	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgacggcatctgtgaagtcGtgcaccaggtggcaggccct	14	11	1	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr19:16034748G>A	uc002nbu.2	-	7	828	c.792C>T	c.(790-792)CAC>CAT	p.H264H	CYP4F11_uc010eab.1_Silent_p.H264H|CYP4F11_uc002nbt.2_Silent_p.H264H	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	264					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						CTGTGAAGTCGTGCACCAGGT	0.527													A	16034748	A	A	16034748	2	1	87	1	0	0	0	0	0	0	0	1	4186	1136	40	1		1	CYP4F11	19	16034748	Silent	SNP	G	TCGA-06-5410-01A-01D-1696-08		16034748	43094235	28	5873											
USE1	55850	broad.mit.edu	37	chr19	17329200	17329200	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatggacgtaaggaagagaaCgtgagtgtctgcggccctgg	17	7	1	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr19:17329200C>T	uc002nfo.2	+	6	482	c.422C>T	c.(421-423)ACT>ATT	p.T141I	USE1_uc002nfn.2_3'UTR|USE1_uc010eal.1_Missense_Mutation_p.T141I	NM_018467	NP_060937	Q9NZ43	USE1_HUMAN	unconventional SNARE in the ER 1 homolog	141	Cytoplasmic (Potential).				lysosomal transport|protein catabolic process|protein transport|secretion by cell|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	protein binding				0						AGGAAGAGAACGTGAGTGTCT	0.582													T	17329200	T	T	17329200	3	4	87	1	0	0	0	0	1	0	0	0	17028	550	19	1	444	1	USE1	19	17329200	Missense_Mutation	SNP	C	TCGA-06-5410-01A-01D-1696-08	1294452	17329200	41799783	29	5874											
PSG1	5669	broad.mit.edu	37	chr19	43382389	43382389	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctcggcttcaatcgtgaCttgggcagtggtgggcaggt	17	8	1	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr19:43382389C>T	uc002ovb.2	-	2	244	c.106G>A	c.(106-108)GTC>ATC	p.V36I	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.V36I|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.V36I|PSG1_uc010eio.1_Missense_Mutation_p.V36I|PSG1_uc002oux.1_5'UTR|PSG1_uc002ouy.1_Missense_Mutation_p.V36I|PSG1_uc002ouz.1_Missense_Mutation_p.V36I|PSG1_uc002ova.1_Missense_Mutation_p.V36I|PSG1_uc002ovc.2_Missense_Mutation_p.V36I|PSG1_uc002ovd.1_Missense_Mutation_p.V36I	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	36	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TCAATCGTGACTTGGGCAGTG	0.463													T	43382389	T	T	43382389	3	4	87	1	0	0	0	0	1	0	0	0	12653	565	20	3	1226	3	PSG1	19	43382389	Missense_Mutation	SNP	C	TCGA-06-5410-01A-01D-1696-08	26053189	43382389	15746594	30	5875											
CACNG6	59285	broad.mit.edu	37	chr19	54503003	54503003	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagttcctgctccgagttggAgccgtctgctttggcctctc	12	13	2	0			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr19:54503003A>G	uc002qct.2	+	3	1112	c.522A>G	c.(520-522)GGA>GGG	p.G174G	CACNG6_uc002qcu.2_Intron|CACNG6_uc002qcv.2_Intron	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	174	Helical; (Potential).					voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		TCCGAGTTGGAGCCGTCTGCT	0.587													G	54503003	G	G	54503003	2	3	87	1	0	0	0	0	0	0	0	1	2561	291	11	4		4	CACNG6	19	54503003	Silent	SNP	A	TCGA-06-5410-01A-01D-1696-08	11120614	54503003	4625980	31	5876											
SYN3	8224	broad.mit.edu	37	chr22	32937634	32937634	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgaaggcctcggtggtggcGtaggttttggccatggcgac	17	8	0	1	rs148217218		TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chr22:32937634G>A	uc003amx.2	-	7	999	c.840C>T	c.(838-840)TAC>TAT	p.Y280Y	SYN3_uc003amy.2_Silent_p.Y280Y|SYN3_uc003amz.2_Silent_p.Y279Y	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	280	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						CGGTGGTGGCGTAGGTTTTGG	0.552													A	32937634	A	A	32937634	2	1	87	1	0	0	0	0	0	0	0	1	15439	1140	40	1		1	SYN3	22	32937634	Silent	SNP	G	TCGA-06-5410-01A-01D-1696-08		32937634	18366932	32	5877											
ZBED1	9189	broad.mit.edu	37	chrX	2407462	2407462	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcggtctccttgatgttgagCgtggtgttcaggagcatgtg	15	7	2	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chrX:2407462C>T	uc004cqg.2	-	2	1500	c.1299G>A	c.(1297-1299)ACG>ACA	p.T433T	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Silent_p.T433T	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	433						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGATGTTGAGCGTGGTGTTCA	0.597													T	2407462	T	T	2407462	2	4	87	1	0	0	0	0	0	0	0	1	17514	755	27	1		1	ZBED1	23	2407462	Silent	SNP	C	TCGA-06-5410-01A-01D-1696-08		2407462	152863098	33	5878											
RAI2	10742	broad.mit.edu	37	chrX	17818684	17818684	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcccatggactcttccccttGgctgttgatgtcatagccct	8	14	2	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chrX:17818684G>C	uc004cyf.2	-	3	2017	c.1447C>G	c.(1447-1449)CAA>GAA	p.Q483E	RAI2_uc004cyg.2_Missense_Mutation_p.Q483E|RAI2_uc010nfa.2_Missense_Mutation_p.Q483E|RAI2_uc004cyh.3_Missense_Mutation_p.Q483E|RAI2_uc011miy.1_Missense_Mutation_p.Q433E	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	483					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					TCTTCCCCTTGGCTGTTGATG	0.468													C	17818684	C	C	17818684	3	2	87	1	0	0	0	0	1	0	0	0	13009	1357	47	5	149	5	RAI2	23	17818684	Missense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08	15411222	17818684	137451876	34	5879											
EIF2S3	1968	broad.mit.edu	37	chrX	24073154	24073154	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtcaggatctcaccaccttGgtgaggttttgcttggggag	14	9	2	1			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chrX:24073154G>A	uc004dbc.2	+	1	90	c.69G>A	c.(67-69)TTG>TTA	p.L23L		NM_001415	NP_001406	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2,	23						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			lung(1)	1						TCACCACCTTGGTGAGGTTTT	0.587											OREG0019714	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	24073154	A	A	24073154	2	1	87	1	0	0	0	0	0	0	0	1	5011	1362	47	3		3	EIF2S3	23	24073154	Silent	SNP	G	TCGA-06-5410-01A-01D-1696-08	6254470	24073154	131197406	35	5880											
PORCN	64840	broad.mit.edu	37	chrX	48368320	48368320	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctccttgccatctgcctcGcctgccgcctcctctggagg	10	18	2	0			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chrX:48368320G>A	uc010nie.1	+	2	270	c.112G>A	c.(112-114)GCC>ACC	p.A38T	PORCN_uc004djq.1_Missense_Mutation_p.A151T|PORCN_uc004djr.1_Missense_Mutation_p.A38T|PORCN_uc004djs.1_Missense_Mutation_p.A38T|PORCN_uc004djt.1_5'UTR|PORCN_uc011mlx.1_5'UTR|PORCN_uc004dju.1_5'UTR|PORCN_uc004djv.1_Missense_Mutation_p.A38T|PORCN_uc004djw.1_Missense_Mutation_p.A38T	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	38	Helical; (Potential).|Leu-rich.				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						CATCTGCCTCGCCTGCCGCCT	0.413													A	48368320	A	A	48368320	3	1	87	1	0	0	0	0	1	0	0	0	12258	1087	38	1	114	1	PORCN	23	48368320	Missense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08	24295166	48368320	106902240	36	5881											
WNK3	65267	broad.mit.edu	37	chrX	54276526	54276526	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtctgattgatacagaatcGccaccgaccaactggggatg	11	11	1	3			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chrX:54276526G>A	uc004dtd.1	-	16	3053	c.2614C>T	c.(2614-2616)CGA>TGA	p.R872*	WNK3_uc004dtc.1_Nonsense_Mutation_p.R872*	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	872					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						ATACAGAATCGCCACCGACCA	0.423													A	54276526	A	A	54276526	4	1	87	1	0	0	0	0	0	1	0	0	17376	1095	38	1	2824	1	WNK3	23	54276526	Nonsense_Mutation	SNP	G	TCGA-06-5410-01A-01D-1696-08	5908206	54276526	100994034	37	5882											
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011568	105011568	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctaccccttaataacaccCtgaaagatacccaggaattt	5	12	0	2			TCGA-06-5410-01A-01D-1696-08	TCGA-06-5410-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	67244284-dc40-46cb-a2ac-3f4a38f7bbe4	2df41e20-041f-4e1e-86d9-3c38e36c9b33	g.chrX:105011568C>T	uc004elz.1	+	11	2731	c.1975C>T	c.(1975-1977)CTG>TTG	p.L659L		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	659	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						TAATAACACCCTGAAAGATAC	0.448													T	105011568	T	T	105011568	2	4	87	1	0	0	0	0	0	0	0	1	7662	680	24	3		3	IL1RAPL2	23	105011568	Silent	SNP	C	TCGA-06-5410-01A-01D-1696-08	50735042	105011568	50258992	38	5883											
MASP2	10747	broad.mit.edu	37	chr1	11087589	11087589	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacccagttgtcatataaaaGtgcacctgctgctgtggttc	10	10	1	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr1:11087589G>A	uc001aru.2	-	11	1435	c.1414C>T	c.(1414-1416)CTT>TTT	p.L472F		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	472	Peptidase S1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		TCATATAAAAGTGCACCTGCT	0.493													A	11087589	A	A	11087589	3	1	88	1	0	0	0	0	1	0	0	0	9323	1029	36	3	650	3	MASP2	1	11087589	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08		11087589	238163032	1	5884											
RNF2	6045	broad.mit.edu	37	chr1	185069006	185069006	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctttagaagaacttcgaaGcaaaggtgaatcaaaccaga	9	7	1	4			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr1:185069006G>A	uc001grc.1	+	6	1054	c.821G>A	c.(820-822)AGC>AAC	p.S274N	RNF2_uc001grd.1_Missense_Mutation_p.S202N|RNF2_uc001gre.1_RNA	NM_007212	NP_009143	Q99496	RING2_HUMAN	ring finger protein 2	274					histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(1)	1		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		GAACTTCGAAGCAAAGGTGAA	0.393													A	185069006	A	A	185069006	3	1	88	1	0	0	0	0	1	0	0	0	13472	971	34	3	839	3	RNF2	1	185069006	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08	173981417	185069006	64181615	2	5885											
SOX13	9580	broad.mit.edu	37	chr1	204085764	204085766	+	In_Frame_Del	DEL	AGC	-	-													ggctgccatgctgtttgagaAgcagcagcagcagatggagc							TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr1:204085764_204085766delAGC	uc001ham.2	+	5	1143_1145	c.548_550delAGC	c.(547-552)AAGCAG>AAG	p.Q187del	SOX13_uc001hal.2_In_Frame_Del_p.Q187del|SOX13_uc010pqp.1_In_Frame_Del_p.Q187del|SOX13_uc010pqq.1_In_Frame_Del_p.Q54del	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	187	Gln-rich.				anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			CTGTTTGAGAAGCAGCAGCAGCA	0.576													-	204085766	-	-	204085764	7	5	88	1	0	1	0	1	0	0	0	0	14944	72	3	0	562	0	SOX13	1	204085764	In_Frame_Del	DEL	AGC	TCGA-06-5411-01A-01D-1696-08	19016758	204085764	45164857	3	5886											
REN	5972	broad.mit.edu	37	chr1	204135375	204135377	+	In_Frame_Del	DEL	AGC	-	-													caaaggtacaggagccccagAgcagcagcagcagtccccag					rs121917743		TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr1:204135375_204135377delAGC	uc001haq.2	-	1	89_91	c.45_47delGCT	c.(43-48)CTGCTC>CTC	p.15_16LL>L		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	15_16			L -> R (in HNFJ2; affects ER translocation and processing of nascent preprorenin, resulting in abolished prorenin and renin biosynthesis and secretion).		angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGAGCCCCAGAGCAGCAGCAGCA	0.581													-	204135377	-	-	204135375	7	5	88	1	0	1	0	1	0	0	0	0	13224	304	11	0	1213	0	REN	1	204135375	In_Frame_Del	DEL	AGC	TCGA-06-5411-01A-01D-1696-08	49611	204135375	45115246	4	5887											
OR2C3	81472	broad.mit.edu	37	chr1	247695277	247695277	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ataatgaggggcatctcgcaAaagaagtggtcgatgcaatt	12	6	1	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr1:247695277A>G	uc009xgy.2	-	2	899	c.537T>C	c.(535-537)TTT>TTC	p.F179F	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			GCATCTCGCAAAAGAAGTGGT	0.557													G	247695277	G	G	247695277	2	3	88	1	0	0	0	0	0	0	0	1	10993	11	1	4		4	OR2C3	1	247695277	Silent	SNP	A	TCGA-06-5411-01A-01D-1696-08	43559902	247695277	1555344	5	5888											
PIGF	5281	broad.mit.edu	37	chr2	46808672	46808672	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtatatccagagtggtgaaAtaacaaggccagccacgtag	11	8	0	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr2:46808672A>G	uc002rvd.2	-	6	769	c.605T>C	c.(604-606)ATT>ACT	p.I202T	RHOQ_uc002rva.2_3'UTR|uc002rvb.2_5'Flank|PIGF_uc002rvc.2_3'UTR	NM_002643	NP_002634	Q07326	PIGF_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	202	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	ethanolaminephosphotransferase activity				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GAGTGGTGAAATAACAAGGCC	0.418													G	46808672	G	G	46808672	3	3	88	1	0	0	0	0	1	0	0	0	11887	101	4	4	58	4	PIGF	2	46808672	Missense_Mutation	SNP	A	TCGA-06-5411-01A-01D-1696-08		46808672	196390701	6	5889											
LBX2	85474	broad.mit.edu	37	chr2	74729804	74729804	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttcgtgactttgggggcgGcaggcctgtgagttgttttc	16	7	0	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr2:74729804G>A	uc002slw.2	-	1	640	c.183C>T	c.(181-183)TGC>TGT	p.C61C	LOC151534_uc002slx.2_RNA	NM_001009812	NP_001009812	Q6XYB7	LBX2_HUMAN	ladybird homeobox 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTTGGGGGCGGCAGGCCTGTG	0.602													A	74729804	A	A	74729804	2	1	88	1	0	0	0	0	0	0	0	1	8654	1195	42	3		3	LBX2	2	74729804	Silent	SNP	G	TCGA-06-5411-01A-01D-1696-08	27921132	74729804	168469569	7	5890											
FAM176A	84141	broad.mit.edu	37	chr2	75720689	75720689	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gccagggtcagcaccagcccGatgcacacgccagaaacaaa	10	15	1	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr2:75720689G>A	uc002sni.2	-	4	610	c.132C>T	c.(130-132)ATC>ATT	p.I44I	FAM176A_uc002snj.1_Silent_p.I31I|FAM176A_uc002snk.1_Silent_p.I44I	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	44	Necessary for the localization and biological activity.|Helical; (Potential).				apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						GCACCAGCCCGATGCACACGC	0.537													A	75720689	A	A	75720689	2	1	88	1	0	0	0	0	0	0	0	1	5499	1048	37	2		2	FAM176A	2	75720689	Silent	SNP	G	TCGA-06-5411-01A-01D-1696-08	990885	75720689	167478684	8	5891											
DNAH7	56171	broad.mit.edu	37	chr2	196689149	196689149	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caaaataggatctagttcttCgccaacattttctagcaaca	5	10	3	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr2:196689149C>T	uc002utj.3	-	49	9222	c.9121G>A	c.(9121-9123)GAA>AAA	p.E3041K		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3041	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCTAGTTCTTCGCCAACATTT	0.338													T	196689149	T	T	196689149	3	4	88	1	0	0	0	0	1	0	0	0	4606	893	31	2	3021	2	DNAH7	2	196689149	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08	120968460	196689149	46510224	9	5892											
ABI2	10152	broad.mit.edu	37	chr2	204260428	204260428	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caagtagtcggagcagcagtCgagagaacagtggaagtggt	16	6	0	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr2:204260428C>T	uc002vaa.2	+	7	1010	c.775C>T	c.(775-777)CGA>TGA	p.R259*	ABI2_uc010zig.1_RNA|ABI2_uc002uzz.2_Nonsense_Mutation_p.R253*|ABI2_uc010zih.1_Intron|ABI2_uc010zii.1_Nonsense_Mutation_p.R253*|ABI2_uc010zij.1_Nonsense_Mutation_p.R197*|ABI2_uc002vab.2_Nonsense_Mutation_p.R208*|ABI2_uc010zik.1_Nonsense_Mutation_p.R45*|ABI2_uc010zil.1_Nonsense_Mutation_p.R94*|ABI2_uc010zim.1_Nonsense_Mutation_p.R45*|ABI2_uc002vac.2_Nonsense_Mutation_p.R45*|ABI2_uc010zin.1_Intron	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	259	Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0						GAGCAGCAGTCGAGAGAACAG	0.478													T	204260428	T	T	204260428	4	4	88	1	0	0	0	0	0	1	0	0	89	876	31	2	779	2	ABI2	2	204260428	Nonsense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08	7571279	204260428	38938945	10	5893											
RAF1	5894	broad.mit.edu	37	chr3	12632402	12632402	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggctgctgccctcgcaccacTgggtcacaattgccaggttg	12	14	1	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr3:12632402T>C	uc003bxf.3	-	12	1680	c.1265A>G	c.(1264-1266)CAG>CGG	p.Q422R	RAF1_uc011aut.1_Missense_Mutation_p.Q207R|RAF1_uc011auu.1_Missense_Mutation_p.Q340R	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	422	Protein kinase.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	CTCGCACCACTGGGTCACAAT	0.448			T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				C	12632402	C	C	12632402	3	2	88	1	0	0	0	0	1	0	0	0	13002	1580	55	4	705	4	RAF1	3	12632402	Missense_Mutation	SNP	T	TCGA-06-5411-01A-01D-1696-08		12632402	185390028	11	5894											
SCN5A	6331	broad.mit.edu	37	chr3	38591931	38591931	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ggtggctctagtgacactgtCataggagggtgggaaggaag	18	5	2	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr3:38591931C>G	uc003cio.2	-	28	6126	c.5932G>C	c.(5932-5934)GAC>CAC	p.D1978H	SCN5A_uc003cin.2_Missense_Mutation_p.D1977H|SCN5A_uc003cil.3_Missense_Mutation_p.D1978H|SCN5A_uc010hhi.2_Missense_Mutation_p.D1960H|SCN5A_uc010hhk.2_Missense_Mutation_p.D1945H|SCN5A_uc011ayr.1_Missense_Mutation_p.D1924H	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1978				D->A: No effect on interaction with NEDD4, NEDD4L or WWP2.	blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTGACACTGTCATAGGAGGGT	0.602													G	38591931	G	G	38591931	3	3	88	1	0	0	0	0	1	0	0	0	13922	826	29	5	122	5	SCN5A	3	38591931	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08	25959529	38591931	159430499	12	5895											
SLC9A9	285195	broad.mit.edu	37	chr3	143212496	143212496	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tataacatagttcacataccTgaaaacatcatcatgtgctg	5	9	3	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr3:143212496T>C	uc003evn.2	-	11	1496	c.1314A>G	c.(1312-1314)TCA>TCG	p.S438S		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	438	Helical; (Potential).				regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						TTCACATACCTGAAAACATCA	0.403													C	143212496	C	C	143212496	2	2	88	1	0	0	0	0	0	0	0	1	14721	1594	55	4		4	SLC9A9	3	143212496	Silent	SNP	T	TCGA-06-5411-01A-01D-1696-08	104620565	143212496	54809934	13	5896											
KIT	3815	broad.mit.edu	37	chr4	55597497	55597497	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtttcatctctcccagcagCgatagtactaatgagtacat	7	10	2	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr4:55597497C>T	uc010igr.2	+	15	2232	c.2145C>T	c.(2143-2145)AGC>AGT	p.S715S	KIT_uc010igs.2_Silent_p.S711S|KIT_uc010igt.1_Silent_p.C163C	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	715	Protein kinase.|Cytoplasmic (Potential).				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.S715del(7)		soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTCCCAGCAGCGATAGTACTA	0.458		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				T	55597497	T	T	55597497	2	4	88	1	0	0	0	0	0	0	0	1	8329	767	27	1		1	KIT	4	55597497	Silent	SNP	C	TCGA-06-5411-01A-01D-1696-08		55597497	135556779	14	5897											
ARL9	132946	broad.mit.edu	37	chr4	57389924	57389924	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttggcattatctgaagtggGaaatgacaggaagatgttct	12	4	2	3			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr4:57389924G>A	uc003hby.1	+	4	702	c.254G>A	c.(253-255)GGA>GAA	p.G85E		NM_206919	NP_996802	Q6T311	ARL9_HUMAN	ADP-ribosylation factor-like 9	149							GTP binding				0	Glioma(25;0.08)|all_neural(26;0.101)					TCTGAAGTGGGAAATGACAGG	0.433													A	57389924	A	A	57389924	3	1	88	1	0	0	0	0	1	0	0	0	948	1174	41	3	264	3	ARL9	4	57389924	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08	1792427	57389924	133764352	15	5898											
UGT2B10	7365	broad.mit.edu	37	chr4	69885591	69885591	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agccaggagtgaagctgtgaCtgtacacaaagggtatgtta	13	6	0	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr4:69885591C>G	uc011cao.1	-	4	534	c.398G>C	c.(397-399)AGT>ACT	p.S133T	UGT2B10_uc011can.1_Intron			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	170					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GAAGCTGTGACTGTACACAAA	0.408													G	69885591	G	G	69885591	3	3	88	1	0	0	0	0	1	0	0	0	16953	564	20	5	2712	5	UGT2B10	4	69885591	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08	12495667	69885591	121268685	16	5899											
MUC7	4589	broad.mit.edu	37	chr4	71346617	71346617	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccacattatcctggactgctAgctcaccagaagccgttcat	7	14	2	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr4:71346617A>G	uc011cat.1	+	4	444	c.156A>G	c.(154-156)CTA>CTG	p.L52L	MUC7_uc011cau.1_Silent_p.L52L|MUC7_uc003hfj.2_Silent_p.L52L|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	52						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CTGGACTGCTAGCTCACCAGA	0.453													G	71346617	G	G	71346617	2	3	88	1	0	0	0	0	0	0	0	1	9981	407	15	4		4	MUC7	4	71346617	Silent	SNP	A	TCGA-06-5411-01A-01D-1696-08	1461026	71346617	119807659	17	5900											
CARD6	84674	broad.mit.edu	37	chr5	40853218	40853218	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggagagtgaagaggctcaaaTttttcagaggatactgaact	12	5	2	5			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr5:40853218T>A	uc003jmg.2	+	3	1859	c.1784T>A	c.(1783-1785)ATT>AAT	p.I595N		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	595					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						GAGGCTCAAATTTTTCAGAGG	0.483													A	40853218	A	A	40853218	3	1	88	1	0	0	0	0	1	0	0	0	2650	1493	52	5	1794	5	CARD6	5	40853218	Missense_Mutation	SNP	T	TCGA-06-5411-01A-01D-1696-08		40853218	140062042	18	5901											
RGNEF	64283	broad.mit.edu	37	chr5	73045681	73045681	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggcagatgatgatctatgCgaagtttgacaaaaatgtgt	13	4	1	4			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr5:73045681C>T	uc011csq.1	+	2	64	c.53C>T	c.(52-54)GCG>GTG	p.A18V	RGNEF_uc003kcx.2_Missense_Mutation_p.A18V|RGNEF_uc003kcy.1_Missense_Mutation_p.A18V|RGNEF_uc010izf.2_Missense_Mutation_p.A18V	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	18					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		ATGATCTATGCGAAGTTTGAC	0.443													T	73045681	T	T	73045681	3	4	88	1	0	0	0	0	1	0	0	0	13283	768	27	1	59	1	RGNEF	5	73045681	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08	32192463	73045681	107869579	19	5902											
GABRA6	2559	broad.mit.edu	37	chr5	161119124	161119124	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatcttcagacacagaaggCcaaaaggaaggcacagtttg	10	9	2	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr5:161119124C>T	uc003lyu.2	+	8	1342	c.1004C>T	c.(1003-1005)GCC>GTC	p.A335V	GABRA6_uc003lyv.2_Missense_Mutation_p.A106V	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	335	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACACAGAAGGCCAAAAGGAAG	0.438										TCGA Ovarian(5;0.080)			T	161119124	T	T	161119124	3	4	88	1	0	0	0	0	1	0	0	0	6165	739	26	3	1034	3	GABRA6	5	161119124	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08	88073443	161119124	19796136	20	5903											
TLX3	30012	broad.mit.edu	37	chr5	170736674	170736674	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcccggggccgtgccacCgcctctgccaagcgcgctac	13	19	1	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr5:170736674C>T	uc003mbf.2	+	1	387	c.305C>T	c.(304-306)CCG>CTG	p.P102L	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	102						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCCGTGCCACCGCCTCTGCCA	0.701			T	BCL11B	T-ALL								T	170736674	T	T	170736674	3	4	88	1	0	0	0	0	1	0	0	0	15959	652	23	2	307	2	TLX3	5	170736674	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08	9617550	170736674	10178586	21	5904											
DNAH11	8701	broad.mit.edu	37	chr7	21784532	21784532	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caacagcccctcatttattgCcactttgctgatagagggaa	8	11	1	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr7:21784532C>T	uc003svc.2	+	52	8413	c.8382C>T	c.(8380-8382)TGC>TGT	p.C2794C		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2794					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCATTTATTGCCACTTTGCTG	0.448									Kartagener_syndrome				T	21784532	T	T	21784532	2	4	88	1	0	0	0	0	0	0	0	1	4599	747	26	3		3	DNAH11	7	21784532	Silent	SNP	C	TCGA-06-5411-01A-01D-1696-08		21784532	137354131	22	5905											
OR6V1	346517	broad.mit.edu	37	chr7	142749846	142749846	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atggcactctgatgagccggGctatgtgtgtccagctggct	14	10	1	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr7:142749846G>T	uc011ksv.1	+	1	409	c.409G>T	c.(409-411)GCT>TCT	p.A137S		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					GATGAGCCGGGCTATGTGTGT	0.597													T	142749846	T	T	142749846	3	4	88	1	0	0	0	0	1	0	0	0	11211	1203	42	5	411	5	OR6V1	7	142749846	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08	120965314	142749846	16388817	23	5906											
TEX15	56154	broad.mit.edu	37	chr8	30695499	30695499	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcatttcaaccttttttggCgttaaatgatttcttttcag	6	7	3	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr8:30695499C>T	uc003xil.2	-	3	7152	c.7152G>A	c.(7150-7152)ACG>ACA	p.T2384T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2384										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CCTTTTTTGGCGTTAAATGAT	0.388													T	30695499	T	T	30695499	2	4	88	1	0	0	0	0	0	0	0	1	15776	755	27	1		1	TEX15	8	30695499	Silent	SNP	C	TCGA-06-5411-01A-01D-1696-08		30695499	115668523	24	5907											
GPR124	25960	broad.mit.edu	37	chr8	37697018	37697018	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgagactgtttccgggcagcTccatccgtgtgtcccggaaa	12	13	0	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr8:37697018T>C	uc003xkj.2	+	16	2752	c.2389T>C	c.(2389-2391)TCC>CCC	p.S797P	GPR124_uc010lvy.2_Missense_Mutation_p.S580P	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	797	Cytoplasmic (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TCCGGGCAGCTCCATCCGTGT	0.592													C	37697018	C	C	37697018	3	2	88	1	0	0	0	0	1	0	0	0	6638	1565	54	4	2430	4	GPR124	8	37697018	Missense_Mutation	SNP	T	TCGA-06-5411-01A-01D-1696-08	7001519	37697018	108667004	25	5908											
TBC1D2	55357	broad.mit.edu	37	chr9	101014108	101014108	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccattcccagccagggcgGcatcaggggtggcaggaggt	17	12	1	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr9:101014108G>A	uc011lvb.1	-	2	650	c.470C>T	c.(469-471)GCC>GTC	p.A157V	TBC1D2_uc004ayq.2_Missense_Mutation_p.A157V|TBC1D2_uc004ayr.2_Intron|TBC1D2_uc004ayo.3_Missense_Mutation_p.A157V	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	157	Interaction with CADH1.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		AGCCAGGGCGGCATCAGGGGT	0.637													A	101014108	A	A	101014108	3	1	88	1	0	0	0	0	1	0	0	0	15605	1203	42	3	2331	3	TBC1D2	9	101014108	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08		101014108	40199323	26	5909											
TTLL11	158135	broad.mit.edu	37	chr9	124751932	124751932	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgctctggagggtccctgCcaggcggatgtcactggggt	16	12	2	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr9:124751932C>T	uc004blt.1	-	4	1269	c.1081G>A	c.(1081-1083)GCA>ACA	p.A361T	TTLL11_uc011lyl.1_Missense_Mutation_p.A361T|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Missense_Mutation_p.A38T|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	361	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						AGGGTCCCTGCCAGGCGGATG	0.517													T	124751932	T	T	124751932	3	4	88	1	0	0	0	0	1	0	0	0	16721	739	26	3	1423	3	TTLL11	9	124751932	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08	23737824	124751932	16461499	27	5910											
TTLL11	158135	broad.mit.edu	37	chr9	124794081	124794081	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	actcctcaggaaagagattcTgcatggttctcactgctctg	9	11	4	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr9:124794081T>A	uc004blt.1	-	3	1072	c.884A>T	c.(883-885)CAG>CTG	p.Q295L	TTLL11_uc011lyl.1_Missense_Mutation_p.Q295L|TTLL11_uc004blr.2_Intron|TTLL11_uc011lym.1_Intron|TTLL11_uc004blu.1_Intron	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	295	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						AAAGAGATTCTGCATGGTTCT	0.507													A	124794081	A	A	124794081	3	1	88	1	0	0	0	0	1	0	0	0	16721	1580	55	5	1624	5	TTLL11	9	124794081	Missense_Mutation	SNP	T	TCGA-06-5411-01A-01D-1696-08	42149	124794081	16419350	28	5911											
PTEN	5728	broad.mit.edu	37	chr10	89692904	89692904	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgtaaagctggaaagggaCgaactggtgtaatgatatgt	13	4	0	1	rs121909224		TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr10:89692904C>T	uc001kfb.2	+	6	1419	c.388C>T	c.(388-390)CGA>TGA	p.R130*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).	R->M: Does not affect the ability to inhibit AKT/PKB activation.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130G(65)|p.R130*(61)|p.R130Q(43)|p.R130fs*4(12)|p.R130L(7)|p.R130P(4)|p.R55fs*1(4)|p.K128_R130del(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.K128fs*47(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.R130R(1)|p.F56fs*2(1)|p.G129fs*50(1)|p.G129fs*51(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGGAAAGGGACGAACTGGTGT	0.403	R130G(OV56_OVARY)|R130G(KMBC2_URINARY_TRACT)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89692904	T	T	89692904	4	4	88	1	0	0	0	0	0	1	0	0	12738	528	19	1	406	1	PTEN	10	89692904	Nonsense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08		89692904	45841843	29	5912											
ANO9	338440	broad.mit.edu	37	chr11	420528	420528	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccatcttgatggcgtccaggCggatctccacgaggttgctg	13	12	2	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr11:420528C>T	uc001lpi.2	-	19	1806	c.1721G>A	c.(1720-1722)CGC>CAC	p.R574H	ANO9_uc001lph.2_Missense_Mutation_p.R267H|ANO9_uc010qvv.1_Missense_Mutation_p.R430H	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	574	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GGCGTCCAGGCGGATCTCCAC	0.682													T	420528	T	T	420528	3	4	88	1	0	0	0	0	1	0	0	0	704	768	27	1	647	1	ANO9	11	420528	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08		420528	134585988	30	5913											
OR4D11	219986	broad.mit.edu	37	chr11	59271634	59271634	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gcactgacacttttgctcttGagttcttgatgatttccaac	7	10	2	4			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr11:59271634G>T	uc001noa.1	+	1	586	c.586G>T	c.(586-588)GAG>TAG	p.E196*		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTTTGCTCTTGAGTTCTTGAT	0.493													T	59271634	T	T	59271634	4	4	88	1	0	0	0	0	0	1	0	0	11055	1291	45	5	588	5	OR4D11	11	59271634	Nonsense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08	58851106	59271634	75734882	31	5914											
CTTN	2017	broad.mit.edu	37	chr11	70255986	70255986	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aagagcatcagacccttaagGagaaggaacttgaaacagga	11	7	1	4			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr11:70255986G>A	uc001opv.3	+	5	417	c.211G>A	c.(211-213)GAG>AAG	p.E71K	CTTN_uc001opu.2_Missense_Mutation_p.E71K|CTTN_uc001opw.3_Missense_Mutation_p.E71K	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	71						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GACCCTTAAGGAGAAGGAACT	0.468													A	70255986	A	A	70255986	3	1	88	1	0	0	0	0	1	0	0	0	4044	1175	41	3	221	3	CTTN	11	70255986	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08	10984352	70255986	64750530	32	5915											
PRB3	5544	broad.mit.edu	37	chr12	11420518	11420518	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtccttctggctttcccGgacgaggtgggggaccttgg	17	10	1	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr12:11420518G>A	uc001qzs.2	-	3	703	c.665C>T	c.(664-666)CCA>CTA	p.P222L	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	222	9.|10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.					extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TGGCTTTCCCGGACGAGGTGG	0.617													A	11420518	A	A	11420518	3	1	88	1	0	0	0	0	1	0	0	0	12444	1116	39	2	272	2	PRB3	12	11420518	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08		11420518	122431377	33	5916			1	21		2	2	64	G		9.97148e-05
PRB3	5544	broad.mit.edu	37	chr12	11420581	11420581	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtccttctggctttcccGgacgaggtgggggaccttgg	17	10	1	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr12:11420581G>A	uc001qzs.2	-	3	640	c.602C>T	c.(601-603)CCG>CTG	p.P201L	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	201	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|8.|Pro-rich.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TGGCTTTCCCGGACGAGGTGG	0.632													A	11420581	A	A	11420581	3	1	88	1	0	0	0	0	1	0	0	0	12444	1116	39	2	335	2	PRB3	12	11420581	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08	63	11420581	122431314	34	5917			1	21		2	2	64	G		9.97148e-05
MYF6	4618	broad.mit.edu	37	chr12	81101720	81101720	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagcctccacactgcccCggccagtgtctgatctgggc	11	17	2	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr12:81101720C>T	uc001szf.1	+	1	275	c.222C>T	c.(220-222)CCC>CCT	p.P74P		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	74					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CACACTGCCCCGGCCAGTGTC	0.652													T	81101720	T	T	81101720	2	4	88	1	0	0	0	0	0	0	0	1	10028	639	23	2		2	MYF6	12	81101720	Silent	SNP	C	TCGA-06-5411-01A-01D-1696-08	69681139	81101720	52750175	35	5918											
UBC	7316	broad.mit.edu	37	chr12	125397269	125397269	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcttccagctgttttccgGcaaagatcaacctctgctgg	8	13	3	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr12:125397269G>A	uc001ugs.3	-	2	1497	c.1049C>T	c.(1048-1050)GCC>GTC	p.A350V	UBC_uc001ugr.2_Intron|UBC_uc001ugu.1_Missense_Mutation_p.A350V|UBC_uc001ugt.2_Missense_Mutation_p.A350V|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Missense_Mutation_p.A198V	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	350	Ubiquitin-like 5.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CTGTTTTCCGGCAAAGATCAA	0.522													A	125397269	A	A	125397269	3	1	88	1	0	0	0	0	1	0	0	0	16839	1203	42	3	1012	3	UBC	12	125397269	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08	44295549	125397269	8454626	36	5919											
CCNA1	8900	broad.mit.edu	37	chr13	37011790	37011790	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcacaagaatcaggtgttatTctggatcagaaaatgccttc	8	8	4	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr13:37011790T>A	uc001uvr.3	+	3	672	c.322T>A	c.(322-324)TCT>ACT	p.S108T	CCNA1_uc010teo.1_Missense_Mutation_p.S64T|CCNA1_uc010abq.2_Missense_Mutation_p.S64T|CCNA1_uc010abp.2_Missense_Mutation_p.S64T|CCNA1_uc001uvs.3_Missense_Mutation_p.S107T|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	108					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		CAGGTGTTATTCTGGATCAGA	0.468													A	37011790	A	A	37011790	3	1	88	1	0	0	0	0	1	0	0	0	2909	1783	62	5	332	5	CCNA1	13	37011790	Missense_Mutation	SNP	T	TCGA-06-5411-01A-01D-1696-08		37011790	78158088	37	5920											
C15orf2	23742	broad.mit.edu	37	chr15	24921520	24921520	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggatgaggatccggtgcagaTcgaaggggaggatgacgaga	19	5	0	4			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr15:24921520T>C	uc001ywo.2	+	1	980	c.506T>C	c.(505-507)ATC>ACC	p.I169T		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	169					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCGGTGCAGATCGAAGGGGAG	0.612													C	24921520	C	C	24921520	3	2	88	1	0	0	0	0	1	0	0	0	1784	1435	50	4	508	4	C15orf2	15	24921520	Missense_Mutation	SNP	T	TCGA-06-5411-01A-01D-1696-08		24921520	77609872	38	5921											
MYO15A	51168	broad.mit.edu	37	chr17	18024801	18024801	+	Frame_Shift_Del	DEL	G	-	-													gcccttccaccgaccgcccaGggccggggcctggcgggcgc							TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr17:18024801delG	uc010vxh.1	+	2	3025	c.2687delG	c.(2686-2688)AGGfs	p.R896fs		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	896	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CGACCGCCCAGGGCCGGGGCC	0.741													-	18024801	-	-	18024801	7	5	88	1	0	1	0	1	0	0	0	0	10063	1000	35	0	2689	0	MYO15A	17	18024801	Frame_Shift_Del	DEL	G	TCGA-06-5411-01A-01D-1696-08		18024801	63170409	39	5922											
DSG4	147409	broad.mit.edu	37	chr18	28992962	28992962	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tagatccaaaatttaggactCttgctgagatctgcttaaac	7	8	2	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr18:28992962C>T	uc002kwq.2	+	16	2662	c.2527C>T	c.(2527-2529)CTT>TTT	p.L843F	DSG4_uc002kwr.2_Missense_Mutation_p.L862F	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	843	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ATTTAGGACTCTTGCTGAGAT	0.438													T	28992962	T	T	28992962	3	4	88	1	0	0	0	0	1	0	0	0	4779	913	32	3	2710	3	DSG4	18	28992962	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08		28992962	49084286	40	5923											
LMAN1	3998	broad.mit.edu	37	chr18	57014768	57014768	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcttttccaggttcagtcaActggaaagtcagaaaagaaa	8	8	4	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr18:57014768A>G	uc002lhz.2	-	7	831	c.799T>C	c.(799-801)TTG>CTG	p.L267L		NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor	267	Lumenal (Potential).|L-type lectin-like.				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	GGTTCAGTCAACTGGAAAGTC	0.279													G	57014768	G	G	57014768	2	3	88	1	0	0	0	0	0	0	0	1	8836	40	2	4		4	LMAN1	18	57014768	Silent	SNP	A	TCGA-06-5411-01A-01D-1696-08	28021806	57014768	21062480	41	5924											
CEACAM20	125931	broad.mit.edu	37	chr19	45016954	45016954	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctctgtggggtgctcctcCttcgggatgggttgtgaggt	18	8	1	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr19:45016954C>T	uc010ejn.1	-	9	1501	c.1485G>A	c.(1483-1485)AAG>AAA	p.K495K	CEACAM20_uc010ejo.1_Silent_p.K495K|CEACAM20_uc010ejp.1_Silent_p.K402K|CEACAM20_uc010ejq.1_Silent_p.K402K	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	495	Cytoplasmic (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				GGTGCTCCTCCTTCGGGATGG	0.388											OREG0025538	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	45016954	T	T	45016954	2	4	88	1	0	0	0	0	0	0	0	1	3191	690	24	3		3	CEACAM20	19	45016954	Silent	SNP	C	TCGA-06-5411-01A-01D-1696-08		45016954	14112029	42	5925											
A1BG	1	broad.mit.edu	37	chr19	58858802	58858802	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtagcggcacctgtagttgCcggcgtgctggggccccacg	17	13	0	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr19:58858802C>T	uc002qsd.3	-	7	1459	c.1397G>A	c.(1396-1398)GGC>GAC	p.G466D	NCRNA00181_uc002qse.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	466	Ig-like V-type 5.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CCTGTAGTTGCCGGCGTGCTG	0.692													T	58858802	T	T	58858802	3	4	88	1	0	0	0	0	1	0	0	0	1	739	26	3	98	3	A1BG	19	58858802	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08	13841848	58858802	270181	43	5926											
KIF16B	55614	broad.mit.edu	37	chr20	16337022	16337022	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttccttgcccgcagaggaCgtagcgtgggatactaattt	11	10	0	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr20:16337022C>T	uc002wpg.1	-	23	3732	c.3574G>A	c.(3574-3576)GTC>ATC	p.V1192I	KIF16B_uc002wpe.1_Missense_Mutation_p.V574I|KIF16B_uc002wpf.1_Intron|KIF16B_uc010gch.1_Missense_Mutation_p.V1141I	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1192	PX.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CCGCAGAGGACGTAGCGTGGG	0.498													T	16337022	T	T	16337022	3	4	88	1	0	0	0	0	1	0	0	0	8278	536	19	1	395	1	KIF16B	20	16337022	Missense_Mutation	SNP	C	TCGA-06-5411-01A-01D-1696-08		16337022	46688498	44	5927											
PCK1	5105	broad.mit.edu	37	chr20	56137841	56137841	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgacggattcaccctacGtggtggccagcatgcggatc	13	12	1	1			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr20:56137841G>A	uc002xyn.3	+	4	659	c.496G>A	c.(496-498)GTG>ATG	p.V166M	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	166					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TTCACCCTACGTGGTGGCCAG	0.617													A	56137841	A	A	56137841	3	1	88	1	0	0	0	0	1	0	0	0	11581	1145	40	1	506	1	PCK1	20	56137841	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08	39800819	56137841	6887679	45	5928											
NRIP1	8204	broad.mit.edu	37	chr21	16340303	16340303	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagacccctgatatgtatGtgtattgagaactggaccat	10	9	0	3			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr21:16340303G>A	uc002yjx.2	-	4	809	c.211C>T	c.(211-213)CAT>TAT	p.H71Y		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	71					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TGATATGTATGTGTATTGAGA	0.458													A	16340303	A	A	16340303	3	1	88	1	0	0	0	0	1	0	0	0	10652	1377	48	3	3269	3	NRIP1	21	16340303	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08		16340303	31789592	46	5929											
TIAM1	7074	broad.mit.edu	37	chr21	32639088	32639088	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tccaggccattttcagccagGgactgggggatgctgggggt	17	9	1	0			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr21:32639088G>C	uc002yow.1	-	5	673	c.201C>G	c.(199-201)TCC>TCG	p.S67S	TIAM1_uc011adk.1_Silent_p.S67S|TIAM1_uc011adl.1_Silent_p.S67S|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	67					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TTTCAGCCAGGGACTGGGGGA	0.617													C	32639088	C	C	32639088	2	2	88	1	0	0	0	0	0	0	0	1	15887	1219	43	5		5	TIAM1	21	32639088	Silent	SNP	G	TCGA-06-5411-01A-01D-1696-08	16298785	32639088	15490807	47	5930											
CBR1	873	broad.mit.edu	37	chr21	37445093	37445093	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	agcccagaagaaggtgcagaGacccctgtgtacttggccct	12	12	0	3			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr21:37445093G>T	uc002yvb.1	+	3	876	c.747G>T	c.(745-747)GAG>GAT	p.E249D	uc011aea.1_Intron|SETD4_uc002yva.2_Intron|CBR1_uc010gmy.1_3'UTR	NM_001757	NP_001748	P16152	CBR1_HUMAN	carbonyl reductase 1	249					drug metabolic process|vitamin K metabolic process	cytoplasm	15-hydroxyprostaglandin dehydrogenase (NADP+) activity|carbonyl reductase (NADPH) activity|prostaglandin-E2 9-reductase activity|protein binding				0					Acetohexamide(DB00414)|Lubiprostone(DB01046)	AAGGTGCAGAGACCCCTGTGT	0.572													T	37445093	T	T	37445093	3	4	88	1	0	0	0	0	1	0	0	0	2708	933	33	5	757	5	CBR1	21	37445093	Missense_Mutation	SNP	G	TCGA-06-5411-01A-01D-1696-08	4806005	37445093	10684802	48	5931											
C21orf29	54084	broad.mit.edu	37	chr21	45953585	45953585	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacatgtccaccgggaggccGcagtccgtggtgagggagaa	16	10	0	2			TCGA-06-5411-01A-01D-1696-08	TCGA-06-5411-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2fdab641-d73b-4f9a-aa4c-c1944f131a69	0f88c693-5a30-43b1-be9e-c96a791d984c	g.chr21:45953585G>A	uc002zfe.1	-	3	591	c.525C>T	c.(523-525)TGC>TGT	p.C175C	C21orf29_uc010gpv.1_Silent_p.C107C	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	175	TSP N-terminal.				cell adhesion	extracellular region	structural molecule activity				0						CCGGGAGGCCGCAGTCCGTGG	0.682													A	45953585	A	A	45953585	2	1	88	1	0	0	0	0	0	0	0	1	2124	1079	38	1		1	C21orf29	21	45953585	Silent	SNP	G	TCGA-06-5411-01A-01D-1696-08	8508492	45953585	2176310	49	5932											
CASZ1	54897	broad.mit.edu	37	chr1	10713867	10713867	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagtggcggcagccagggaCgcagaggactgctggctggt	19	10	0	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr1:10713867C>T	uc001aro.2	-	11	2567	c.2247G>A	c.(2245-2247)GCG>GCA	p.A749A	CASZ1_uc001arp.1_Silent_p.A749A|CASZ1_uc009vmx.2_Silent_p.A773A	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	749					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CAGCCAGGGACGCAGAGGACT	0.667													T	10713867	T	T	10713867	2	4	89	1	0	0	0	0	0	0	0	1	2685	523	19	1		1	CASZ1	1	10713867	Silent	SNP	C	TCGA-06-5412-01A-01D-1696-08		10713867	238536754	1	5933											
GLIS1	148979	broad.mit.edu	37	chr1	54059816	54059816	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctcgcccgagtgcactcGcatgtggatgagcagcttgt	12	12	1	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr1:54059816G>A	uc001cvr.1	-	3	1327	c.760C>T	c.(760-762)CGA>TGA	p.R254*		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	254	C2H2-type 2; atypical.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						GAGTGCACTCGCATGTGGATG	0.652													A	54059816	A	A	54059816	4	1	89	1	0	0	0	0	0	1	0	0	6445	1095	38	1	1134	1	GLIS1	1	54059816	Nonsense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	43345949	54059816	195190805	2	5934											
INADL	10207	broad.mit.edu	37	chr1	62228837	62228837	+	Frame_Shift_Del	DEL	C	-	-													cacttcagcagtccatcaagCaactgaagggtcaagtaagt							TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr1:62228837delC	uc001dab.2	+	3	289	c.175delC	c.(175-177)CAAfs	p.Q59fs	INADL_uc009waf.1_Frame_Shift_Del_p.Q59fs|INADL_uc001daa.2_Frame_Shift_Del_p.Q59fs	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	59	L27.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						GTCCATCAAGCAACTGAAGGG	0.363													-	62228837	-	-	62228837	7	5	89	1	0	1	0	1	0	0	0	0	7731	711	25	0	181	0	INADL	1	62228837	Frame_Shift_Del	DEL	C	TCGA-06-5412-01A-01D-1696-08	8169021	62228837	187021784	3	5935											
ITGA10	8515	broad.mit.edu	37	chr1	145532131	145532131	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcagcacagaagggttcagtCagtcccatgggggccgaccc	13	13	3	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr1:145532131C>T	uc001eoa.2	+	8	851	c.775C>T	c.(775-777)CAG>TAG	p.Q259*	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Nonsense_Mutation_p.Q128*|ITGA10_uc009wiw.2_Nonsense_Mutation_p.Q116*|ITGA10_uc010oyw.1_Nonsense_Mutation_p.Q204*	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	259	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AGGGTTCAGTCAGTCCCATGG	0.443													T	145532131	T	T	145532131	4	4	89	1	0	0	0	0	0	1	0	0	7873	827	29	3	805	3	ITGA10	1	145532131	Nonsense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	83303294	145532131	103718490	4	5936											
CRTC2	200186	broad.mit.edu	37	chr1	153923904	153923904	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagcagggtaagagggggcGcccaaaacaggagatgaagt	17	6	0	3			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr1:153923904G>A	uc010ped.1	-	11	1306	c.1236C>T	c.(1234-1236)GGC>GGT	p.G412G	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Intron	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	412					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AAGAGGGGGCGCCCAAAACAG	0.592													A	153923904	A	A	153923904	2	1	89	1	0	0	0	0	0	0	0	1	3900	1074	38	1		1	CRTC2	1	153923904	Silent	SNP	G	TCGA-06-5412-01A-01D-1696-08	8391773	153923904	95326717	5	5937											
C1orf69	200205	broad.mit.edu	37	chr1	228362896	228362896	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccaacctggccttcatgaaCggcgtgagcttcaccaaagg	10	13	2	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr1:228362896C>T	uc001hsl.3	+	3	842	c.753C>T	c.(751-753)AAC>AAT	p.N251N	C1orf69_uc010pvw.1_Silent_p.N58N	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	251					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CCTTCATGAACGGCGTGAGCT	0.647													T	228362896	T	T	228362896	2	4	89	1	0	0	0	0	0	0	0	1	2057	535	19	1		1	C1orf69	1	228362896	Silent	SNP	C	TCGA-06-5412-01A-01D-1696-08	74438992	228362896	20887725	6	5938											
ZNF496	84838	broad.mit.edu	37	chr1	247464120	247464120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctccaccggctggagtctgtCcggctgcaggtgtatccgcc	13	15	1	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr1:247464120C>T	uc001ico.2	-	9	1930	c.1465G>A	c.(1465-1467)GAC>AAC	p.D489N	ZNF496_uc009xgv.2_Missense_Mutation_p.D525N|ZNF496_uc001icp.2_Missense_Mutation_p.D489N	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	489					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			TGGAGTCTGTCCGGCTGCAGG	0.642													T	247464120	T	T	247464120	3	4	89	1	0	0	0	0	1	0	0	0	17942	855	30	3	302	3	ZNF496	1	247464120	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	19101224	247464120	1786501	7	5939											
OR2G6	391211	broad.mit.edu	37	chr1	248685052	248685052	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccatcattttgtacttctaCgtcttgagccttctggggaa	9	10	4	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr1:248685052C>T	uc001ien.1	+	1	105	c.105C>T	c.(103-105)TAC>TAT	p.Y35Y		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTACTTCTACGTCTTGAGCC	0.463													T	248685052	T	T	248685052	2	4	89	1	0	0	0	0	0	0	0	1	11000	547	19	1		1	OR2G6	1	248685052	Silent	SNP	C	TCGA-06-5412-01A-01D-1696-08	1220932	248685052	565569	8	5940											
DPP10	57628	broad.mit.edu	37	chr2	116593818	116593818	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgtggttgcacctatcacagActtgaaattgtatggtgagt	11	7	1	3			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr2:116593818A>T	uc002tla.1	+	22	2493	c.2036A>T	c.(2035-2037)GAC>GTC	p.D679V	DPP10_uc002tlb.1_Missense_Mutation_p.D629V|DPP10_uc002tlc.1_Missense_Mutation_p.D675V|DPP10_uc002tle.2_Missense_Mutation_p.D683V|DPP10_uc002tlf.1_Missense_Mutation_p.D672V	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	679	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CCTATCACAGACTTGAAATTG	0.368													T	116593818	T	T	116593818	3	4	89	1	0	0	0	0	1	0	0	0	4727	275	10	5	2293	5	DPP10	2	116593818	Missense_Mutation	SNP	A	TCGA-06-5412-01A-01D-1696-08		116593818	126605555	9	5941											
WDR33	55339	broad.mit.edu	37	chr2	128484320	128484320	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actaaccctttggttggatgCcagtctacacatttcacatc	6	12	2	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr2:128484320C>T	uc002tpg.1	-	8	939	c.756G>A	c.(754-756)TGG>TGA	p.W252*		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	252	WD 4.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TGGTTGGATGCCAGTCTACAC	0.408													T	128484320	T	T	128484320	4	4	89	1	0	0	0	0	0	1	0	0	17284	740	26	3	3314	3	WDR33	2	128484320	Nonsense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	11890502	128484320	114715053	10	5942											
HOXD10	3236	broad.mit.edu	37	chr2	176981726	176981726	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaacctgtggactgctcccGtctctggccaaaagagaagt	10	12	1	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr2:176981726G>A	uc002ukj.2	+	1	235	c.165G>A	c.(163-165)CCG>CCA	p.P55P		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	55						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GACTGCTCCCGTCTCTGGCCA	0.488													A	176981726	A	A	176981726	2	1	89	1	0	0	0	0	0	0	0	1	7319	1132	40	1		1	HOXD10	2	176981726	Silent	SNP	G	TCGA-06-5412-01A-01D-1696-08	48497406	176981726	66217647	11	5943											
PLEKHM3	389072	broad.mit.edu	37	chr2	208841462	208841462	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggtagtcacagattggcGtttgttcttcctgagttcat	11	8	3	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr2:208841462G>A	uc002vcl.2	-	3	1949	c.1459C>T	c.(1459-1461)CGC>TGC	p.R487C	PLEKHM3_uc002vcm.2_Missense_Mutation_p.R487C	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	487					intracellular signal transduction		metal ion binding			ovary(1)	1						ACAGATTGGCGTTTGTTCTTC	0.478													A	208841462	A	A	208841462	3	1	89	1	0	0	0	0	1	0	0	0	12082	1145	40	1	850	1	PLEKHM3	2	208841462	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	31859736	208841462	34357911	12	5944											
CCDC108	255101	broad.mit.edu	37	chr2	219874081	219874081	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gttcctaccttgcataccagGtctgcactgtagaagctggc	10	12	1	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr2:219874081G>C	uc002vjl.1	-	28	4638	c.4554C>G	c.(4552-4554)GAC>GAG	p.D1518E		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1518						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCATACCAGGTCTGCACTGT	0.587													C	219874081	C	C	219874081	3	2	89	1	0	0	0	0	1	0	0	0	2743	1252	44	5	1255	5	CCDC108	2	219874081	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	11032619	219874081	23325292	13	5945											
RBM44	375316	broad.mit.edu	37	chr2	238738022	238738022	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatgggaatagaattagttcGaataatttagagaaaagcac	9	3	0	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr2:238738022G>A	uc002vxi.3	+	13	2898	c.2766G>A	c.(2764-2766)TCG>TCA	p.S922S		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	921							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		GAATTAGTTCGAATAATTTAG	0.388													A	238738022	A	A	238738022	2	1	89	1	0	0	0	0	0	0	0	1	13138	1045	37	2		2	RBM44	2	238738022	Silent	SNP	G	TCGA-06-5412-01A-01D-1696-08	18863941	238738022	4461351	14	5946											
CAND2	23066	broad.mit.edu	37	chr3	12858462	12858462	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccacactggcagccctggaCgccctggcccagagccaggg	14	17	0	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr3:12858462C>T	uc003bxk.2	+	10	2080	c.2031C>T	c.(2029-2031)GAC>GAT	p.D677D	CAND2_uc003bxj.2_Silent_p.D584D	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	677	HEAT 14.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						CAGCCCTGGACGCCCTGGCCC	0.662													T	12858462	T	T	12858462	2	4	89	1	0	0	0	0	0	0	0	1	2616	535	19	1		1	CAND2	3	12858462	Silent	SNP	C	TCGA-06-5412-01A-01D-1696-08		12858462	185163968	15	5947											
ZIC4	84107	broad.mit.edu	37	chr3	147113783	147113783	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tttggctttgaagggctttcCctggcgcggacactcctccc	11	14	0	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr3:147113783C>G	uc003ewd.1	-	3	817	c.544G>C	c.(544-546)GGA>CGA	p.G182R	ZIC4_uc003ewc.1_Missense_Mutation_p.G112R|ZIC4_uc011bno.1_Missense_Mutation_p.G232R	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	182	C2H2-type 2; atypical.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AAGGGCTTTCCCTGGCGCGGA	0.597													G	147113783	G	G	147113783	3	3	89	1	0	0	0	0	1	0	0	0	17678	632	22	5	472	5	ZIC4	3	147113783	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	134255321	147113783	50908647	16	5948											
MECOM	2122	broad.mit.edu	37	chr3	168834185	168834185	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccggaaggaaacagaccaGggaagctaaaagaaaatcca	11	8	0	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr3:168834185G>A	uc003ffi.3	-	7	1180	c.911C>T	c.(910-912)CCT>CTT	p.P304L	MECOM_uc010hwk.1_Missense_Mutation_p.P327L|MECOM_uc003ffj.3_Missense_Mutation_p.P369L|MECOM_uc011bpi.1_Missense_Mutation_p.P305L|MECOM_uc003ffn.3_Missense_Mutation_p.P304L|MECOM_uc003ffk.2_Missense_Mutation_p.P304L|MECOM_uc003ffl.2_Missense_Mutation_p.P464L|MECOM_uc011bpj.1_Missense_Mutation_p.P492L|MECOM_uc011bpk.1_Missense_Mutation_p.P294L|MECOM_uc010hwn.2_Missense_Mutation_p.P492L	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	304					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						AAACAGACCAGGGAAGCTAAA	0.473													A	168834185	A	A	168834185	3	1	89	1	0	0	0	0	1	0	0	0	9422	1000	35	3	2284	3	MECOM	3	168834185	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	21720402	168834185	29188245	17	5949											
NAALADL2	254827	broad.mit.edu	37	chr3	174951839	174951839	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	taaattactctgtgctgcttGatctgccaggcccttctccc	7	14	3	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr3:174951839G>A	uc003fit.2	+	3	751	c.664G>A	c.(664-666)GAT>AAT	p.D222N	NAALADL2_uc003fiu.1_Missense_Mutation_p.D215N|NAALADL2_uc010hwy.1_Missense_Mutation_p.D44N	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	222	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TGTGCTGCTTGATCTGCCAGG	0.443													A	174951839	A	A	174951839	3	1	89	1	0	0	0	0	1	0	0	0	10130	1290	45	3	674	3	NAALADL2	3	174951839	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	6117654	174951839	23070591	18	5950											
GNRHR	2798	broad.mit.edu	37	chr4	68606377	68606377	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatgaagtggcaaatgcaaCcgtcatttttagagtcttca	8	7	3	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr4:68606377C>T	uc003hdn.2	-	3	2559	c.808G>A	c.(808-810)GTT>ATT	p.V270I	LOC550112_uc003hdl.3_Intron|GNRHR_uc003hdm.2_Missense_Mutation_p.G227D|uc003hdo.1_5'Flank	NM_000406	NP_000397	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor isoform	270	Cytoplasmic (Potential).				multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			ovary(1)	1					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	GCAAATGCAACCGTCATTTTT	0.408													T	68606377	T	T	68606377	3	4	89	1	0	0	0	0	1	0	0	0	6549	507	18	3	182	3	GNRHR	4	68606377	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08		68606377	122547899	19	5951											
PITX2	5308	broad.mit.edu	37	chr4	111539460	111539460	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgcgtaaggacaggcaggcgTcggcaccgcggaattcagcg	16	12	1	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr4:111539460T>C	uc003iad.2	-	5	1357	c.775A>G	c.(775-777)ACG>GCG	p.T259A	PITX2_uc003iac.2_Missense_Mutation_p.T266A|PITX2_uc003iae.2_Missense_Mutation_p.T213A|PITX2_uc010iml.2_Missense_Mutation_p.T130A|PITX2_uc003iaf.2_Missense_Mutation_p.T259A	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	259					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CAGGCAGGCGTCGGCACCGCG	0.592													C	111539460	C	C	111539460	3	2	89	1	0	0	0	0	1	0	0	0	11955	1667	58	4	182	4	PITX2	4	111539460	Missense_Mutation	SNP	T	TCGA-06-5412-01A-01D-1696-08	42933083	111539460	79614816	20	5952											
PCDHGB1	56104	broad.mit.edu	37	chr5	140730012	140730012	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtccgggagttgccaactcGaaaactgcgggttagtgcag	14	9	0	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr5:140730012G>A	uc003ljo.1	+	1	185	c.185G>A	c.(184-186)CGA>CAA	p.R62Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.R62Q	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	62	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGCCAACTCGAAAACTGCGG	0.522											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	140730012	A	A	140730012	3	1	89	1	0	0	0	0	1	0	0	0	11562	1058	37	2	187	2	PCDHGB1	5	140730012	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08		140730012	40185248	21	5953											
MFAP3	4238	broad.mit.edu	37	chr5	153432941	153432941	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	taaactgtcgagcctttgttGaggagatgtttgaggctgtg	14	5	0	3			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr5:153432941G>A	uc003lvf.2	+	3	1273	c.757G>A	c.(757-759)GAG>AAG	p.E253K	MFAP3_uc010jib.2_Missense_Mutation_p.E253K|MFAP3_uc011ddb.1_Missense_Mutation_p.E107K	NM_001135037	NP_001128509	P55082	MFAP3_HUMAN	microfibrillar-associated protein 3 isoform 2	253	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	Renal(175;0.00488)	Lung NSC(249;0.00145)|all_lung(500;0.00226)|all_neural(177;0.122)|Breast(839;0.14)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;9.69e-06)|GBM - Glioblastoma multiforme(465;0.0201)		AGCCTTTGTTGAGGAGATGTT	0.453													A	153432941	A	A	153432941	3	1	89	1	0	0	0	0	1	0	0	0	9515	1291	45	3	763	3	MFAP3	5	153432941	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	12702929	153432941	27482319	22	5954											
EBF1	1879	broad.mit.edu	37	chr5	158140123	158140123	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaacactgtacagggcctcGgcaatgtcggccgctctctt	12	13	1	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr5:158140123G>A	uc010jip.2	-	13	1526	c.1224C>T	c.(1222-1224)GCC>GCT	p.A408A	EBF1_uc011ddw.1_Silent_p.A276A|EBF1_uc011ddx.1_Silent_p.A409A|EBF1_uc003lxl.3_Silent_p.A377A	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	408					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACAGGGCCTCGGCAATGTCGG	0.522			T	HMGA2	lipoma								A	158140123	A	A	158140123	2	1	89	1	0	0	0	0	0	0	0	1	4880	1103	39	2		2	EBF1	5	158140123	Silent	SNP	G	TCGA-06-5412-01A-01D-1696-08	4707182	158140123	22775137	23	5955											
BTNL3	10917	broad.mit.edu	37	chr5	180432547	180432547	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtatgtgggagtgtgtcGggatgacgtagacaggggga	21	3	0	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr5:180432547G>A	uc003mmr.2	+	8	1204	c.1076G>A	c.(1075-1077)CGG>CAG	p.R359Q	BTNL3_uc010jlp.2_Missense_Mutation_p.R144Q	NM_197975	NP_932079	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3 precursor	359	B30.2/SPRY.|Cytoplasmic (Potential).				lipid metabolic process	integral to membrane					0	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GGAGTGTGTCGGGATGACGTA	0.478													A	180432547	A	A	180432547	3	1	89	1	0	0	0	0	1	0	0	0	1566	1116	39	2	1106	2	BTNL3	5	180432547	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	22292424	180432547	482713	24	5956											
ROS1	6098	broad.mit.edu	37	chr6	117679033	117679033	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtgaatcttcacctctctgGgatatttcaccttgtgttca	7	10	5	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr6:117679033G>T	uc003pxp.1	-	24	3987	c.3788C>A	c.(3787-3789)CCC>CAC	p.P1263H	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1263	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CACCTCTCTGGGATATTTCAC	0.318			T	GOPC|ROS1	glioblastoma|NSCLC								T	117679033	T	T	117679033	3	4	89	1	0	0	0	0	1	0	0	0	13531	1232	43	5	3335	5	ROS1	6	117679033	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08		117679033	53436034	25	5957											
CRHR2	1395	broad.mit.edu	37	chr7	30693212	30693212	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctcttcctcacggctgagCgcacctgtggggaaggcaga	13	13	2	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr7:30693212C>T	uc003tbn.2	-	12	1344	c.1100G>A	c.(1099-1101)CGC>CAC	p.R367H	CRHR2_uc010kvw.1_3'UTR|CRHR2_uc010kvx.1_Missense_Mutation_p.R366H|CRHR2_uc010kvy.1_Missense_Mutation_p.R203H|CRHR2_uc003tbo.2_Missense_Mutation_p.R353H|CRHR2_uc003tbp.2_Missense_Mutation_p.R394H	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	367	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						CACGGCTGAGCGCACCTGTGG	0.642													T	30693212	T	T	30693212	3	4	89	1	0	0	0	0	1	0	0	0	3872	768	27	1	139	1	CRHR2	7	30693212	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08		30693212	128445451	26	5958											
DDX56	54606	broad.mit.edu	37	chr7	44611162	44611162	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgttccaagaacaggcgtagCcggtaactccgttctagagt	11	10	1	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr7:44611162C>A	uc003tlg.2	-	6	1462	c.819G>T	c.(817-819)CGG>CGT	p.R273R	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Silent_p.R209R|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Silent_p.R273R|DDX56_uc010kyh.1_RNA	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	273	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						ACAGGCGTAGCCGGTAACTCC	0.522													A	44611162	A	A	44611162	2	1	89	1	0	0	0	0	0	0	0	1	4374	726	26	5		5	DDX56	7	44611162	Silent	SNP	C	TCGA-06-5412-01A-01D-1696-08	13917950	44611162	114527501	27	5959											
GTF2IRD2	84163	broad.mit.edu	37	chr7	74212399	74212399	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tttttcagctcgtgaagcttCtcgtcacgcattctttccat	6	12	4	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr7:74212399C>T	uc003ubd.1	-	16	1636	c.1452G>A	c.(1450-1452)GAG>GAA	p.E484E	GTF2IRD2_uc010lbt.1_Silent_p.E31E	NM_173537	NP_775808	Q86UP8	GTD2A_HUMAN	GTF2I repeat domain containing 2	484					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						cgtgaagcttctcgtcacgca	0													T	74212399	T	T	74212399	2	4	89	1	0	0	0	0	0	0	0	1	6869	912	32	3		3	GTF2IRD2	7	74212399	Silent	SNP	C	TCGA-06-5412-01A-01D-1696-08	29601237	74212399	84926264	28	5960											
CCL24	6369	broad.mit.edu	37	chr7	75442664	75442664	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgtgctcctgctggacagctGgtagctgaccactcggttct	12	12	1	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr7:75442664G>C	uc011kga.1	-	2	151	c.151C>G	c.(151-153)CAG>GAG	p.Q51E		NM_002991	NP_002982	O00175	CCL24_HUMAN	small inducible cytokine A24 precursor	51					cell-cell signaling|chemotaxis|immune response|inflammatory response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|signal transduction	extracellular space	chemokine activity				0						CTGGACAGCTGGTAGCTGACC	0.562													C	75442664	C	C	75442664	3	2	89	1	0	0	0	0	1	0	0	0	2896	1357	47	5	214	5	CCL24	7	75442664	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	1230265	75442664	83695999	29	5961											
CDHR3	222256	broad.mit.edu	37	chr7	105660961	105660961	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taccgaccttgattccagccCcagatctttccgttattcca	5	15	1	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr7:105660961C>T	uc003vdl.3	+	13	1904	c.1796C>T	c.(1795-1797)CCC>CTC	p.P599L	CDHR3_uc003vdk.2_Intron|CDHR3_uc003vdm.3_Missense_Mutation_p.P586L|CDHR3_uc011klt.1_Missense_Mutation_p.P511L|CDHR3_uc003vdn.2_Intron	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	599	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GATTCCAGCCCCAGATCTTTC	0.488													T	105660961	T	T	105660961	3	4	89	1	0	0	0	0	1	0	0	0	3120	623	22	3	1846	3	CDHR3	7	105660961	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	30218297	105660961	53477702	30	5962											
SND1	27044	broad.mit.edu	37	chr7	127334947	127334948	+	Frame_Shift_Ins	INS	-	A	A													ggaaggaagtctgtttcacgINSatagaaaacaagactcccca							TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr7:127334947_127334948insA	uc003vmi.2	+	3	520_521	c.294_295insA	c.(292-297)ACGATAfs	p.T98fs		NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	98_99	TNase-like 1.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						TCTGTTTCACGATAGAAAACAA	0.465													A	127334948	A	A	127334947	7	5	89	1	0	1	1	0	0	0	0	0	14844	1045	37	0	304	0	SND1	7	127334947	Frame_Shift_Ins	INS	-	TCGA-06-5412-01A-01D-1696-08	21673986	127334947	31803716	31	5963											
KEL	3792	broad.mit.edu	37	chr7	142643377	142643377	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacgtgcctgtctcctccaCgcacttcatccatcgtgggc	9	16	2	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr7:142643377C>T	uc003wcb.2	-	11	1441	c.1231G>A	c.(1231-1233)GTG>ATG	p.V411M		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	411	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GTCTCCTCCACGCACTTCATC	0.567													T	142643377	T	T	142643377	3	4	89	1	0	0	0	0	1	0	0	0	8142	536	19	1	1003	1	KEL	7	142643377	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	15308430	142643377	16495286	32	5964											
SOX7	83595	broad.mit.edu	37	chr8	10583649	10583649	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagggccagggagcccagggGgtggctacagtggagagggc	21	8	0	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr8:10583649G>A	uc003wtf.2	-	2	845	c.766C>T	c.(766-768)CCC>TCC	p.P256S	SOX7_uc011kwz.1_Missense_Mutation_p.P308S	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	256					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GAGCCCAGGGGGTGGCTACAG	0.692													A	10583649	A	A	10583649	3	1	89	1	0	0	0	0	1	0	0	0	14956	1232	43	3	404	3	SOX7	8	10583649	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08		10583649	135780373	33	5965											
HGSNAT	138050	broad.mit.edu	37	chr8	43048945	43048945	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atgaccccgagggcatcctgGgcaccatcaactccatcgtg	10	15	1	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr8:43048945G>C	uc003xpx.3	+	14	1471	c.1423G>C	c.(1423-1425)GGC>CGC	p.G475R		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	503	Helical; (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			GGGCATCCTGGGCACCATCAA	0.428													C	43048945	C	C	43048945	3	2	89	1	0	0	0	0	1	0	0	0	7088	1232	43	5	1477	5	HGSNAT	8	43048945	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	32465296	43048945	103315077	34	5966											
ENPP2	5168	broad.mit.edu	37	chr8	120628516	120628516	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaacttaccggttgacctcCccaccatctatgattaaatt	4	12	1	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr8:120628516C>T	uc003yot.1	-	8	852	c.766G>A	c.(766-768)GGA>AGA	p.G256R	ENPP2_uc003yos.1_Missense_Mutation_p.G256R|ENPP2_uc010mdd.1_Missense_Mutation_p.G256R	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	256					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GGTTGACCTCCCCACCATCTA	0.378													T	120628516	T	T	120628516	3	4	89	1	0	0	0	0	1	0	0	0	5130	632	22	3	2136	3	ENPP2	8	120628516	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	77579571	120628516	25735506	35	5967											
HAS2	3037	broad.mit.edu	37	chr8	122626452	122626452	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcatgacccaatagcatgcaTagagcaacgttccaacaatt	7	11	0	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr8:122626452T>C	uc003yph.2	-	4	2094	c.1556A>G	c.(1555-1557)TAT>TGT	p.Y519C		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	519	Helical; Name=7; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			ATAGCATGCATAGAGCAACGT	0.418													C	122626452	C	C	122626452	3	2	89	1	0	0	0	0	1	0	0	0	6962	1406	49	4	106	4	HAS2	8	122626452	Missense_Mutation	SNP	T	TCGA-06-5412-01A-01D-1696-08	1997936	122626452	23737570	36	5968											
FAM49B	51571	broad.mit.edu	37	chr8	130866513	130866513	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attcaaagcattaacttaccGgtacattgttaatcctcata	4	9	2	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr8:130866513G>A	uc003yss.2	-	10	1064	c.515C>T	c.(514-516)CCG>CTG	p.P172L	FAM49B_uc003yst.2_Missense_Mutation_p.P172L|FAM49B_uc003ysu.2_Missense_Mutation_p.P172L|FAM49B_uc003ysv.2_Missense_Mutation_p.P26L|FAM49B_uc003ysw.2_Missense_Mutation_p.P172L|FAM49B_uc003ysx.2_Missense_Mutation_p.P172L|FAM49B_uc003ysy.1_Missense_Mutation_p.P172L	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	172											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TTAACTTACCGGTACATTGTT	0.348													A	130866513	A	A	130866513	3	1	89	1	0	0	0	0	1	0	0	0	5576	1130	39	2	483	2	FAM49B	8	130866513	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	8240061	130866513	15497509	37	5969											
GSN	2934	broad.mit.edu	37	chr9	124062285	124062285	+	Splice_Site	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcgggtgcccgaggcgcgggTgagtgcccggggggccccgg	23	13	0	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr9:124062285T>G	uc004blf.1	+	1	205	c.144_splice	c.e1+2	p.R48_splice	GSN_uc004bld.1_Intron|GSN_uc010mvq.1_Intron|GSN_uc010mvr.1_Intron|GSN_uc010mvu.1_Intron|GSN_uc010mvt.1_Intron|GSN_uc010mvs.1_Intron|GSN_uc004ble.1_Intron|GSN_uc010mvv.1_Intron|GSN_uc011lyh.1_Intron|GSN_uc011lyi.1_Intron|GSN_uc011lyj.1_5'Flank	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor						actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						gaggcgcgggtgagtgcccgg	0.348													G	124062285	G	G	124062285	5	3	89	1	0	0	0	0	0	0	1	0	6825	1710	59	5	148	5	GSN	9	124062285	Splice_Site	SNP	T	TCGA-06-5412-01A-01D-1696-08		124062285	17151146	38	5970											
ABL1	25	broad.mit.edu	37	chr9	133760582	133760582	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccactccaaagccacagtccGccaagccgtcggggaccccc	9	20	0	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr9:133760582G>A	uc004bzw.2	+	11	2908	c.2905G>A	c.(2905-2907)GCC>ACC	p.A969T	ABL1_uc004bzv.2_Missense_Mutation_p.A988T	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	969	F-actin-binding.|Pro-rich.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GCCACAGTCCGCCAAGCCGTC	0.667			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								A	133760582	A	A	133760582	3	1	89	1	0	0	0	0	1	0	0	0	92	1087	38	1	3087	1	ABL1	9	133760582	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	9698297	133760582	7452849	39	5971											
RXRA	6256	broad.mit.edu	37	chr9	137300840	137300840	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagggcttcttcaagcggaCggtgcgcaaggacctgacct	13	12	2	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr9:137300840C>T	uc004cfb.2	+	4	647	c.485C>T	c.(484-486)ACG>ATG	p.T162M	RXRA_uc004cfc.1_Missense_Mutation_p.T65M	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	162	Nuclear receptor.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	TTCAAGCGGACGGTGCGCAAG	0.647													T	137300840	T	T	137300840	3	4	89	1	0	0	0	0	1	0	0	0	13763	536	19	1	499	1	RXRA	9	137300840	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	3540258	137300840	3912591	40	5972											
PTEN	5728	broad.mit.edu	37	chr10	89720831	89720831	+	Frame_Shift_Del	DEL	G	-	-													caaaaaatgatcttgacaaaGcaaataaagacaaagccaac							TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr10:89720831delG	uc001kfb.2	+	9	2013	c.982delG	c.(982-984)GCAfs	p.A328fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	328	C2 tensin-type.			KANKDKANR->AAGADAANA: Reduces growth suppression activity and promotes anchorage-independent growth. Reduces binding to phospholipid membranes in vitro; phosphatase activity towards PtdIns(3,4,5)P3 is not affected.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.T319_K332del(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.A328fs*15(1)|p.W274_F341del(1)|p.A328fs*1(1)|p.D326_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TCTTGACAAAGCAAATAAAGA	0.333		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89720831	-	-	89720831	7	5	89	1	0	1	0	1	0	0	0	0	12738	971	34	0	1012	0	PTEN	10	89720831	Frame_Shift_Del	DEL	G	TCGA-06-5412-01A-01D-1696-08		89720831	45813916	41	5973											
MUC5B	727897	broad.mit.edu	37	chr11	1283520	1283520	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catccggggggcagtccaggAcccccagcagccactgaagg	14	15	0	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr11:1283520A>C	uc009ycr.1	+	72	18404	c.18278A>C	c.(18277-18279)GAC>GCC	p.D6093A		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:Variant_position_missing_in_Q9HC84_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCAGTCCAGGACCCCCAGCAG	0.657													C	1283520	C	C	1283520	3	2	89	1	0	0	0	0	1	0	0	0	9979	290	10	5		5	MUC5B	11	1283520	Missense_Mutation	SNP	A	TCGA-06-5412-01A-01D-1696-08		1283520	133722996	42	5974											
LRRC32	2615	broad.mit.edu	37	chr11	76371805	76371805	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtggccctgtggggagccGgatgaggttgttggacaagt	20	6	0	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr11:76371805G>A	uc001oxq.3	-	3	1075	c.832C>T	c.(832-834)CGG>TGG	p.R278W	LRRC32_uc001oxr.3_Missense_Mutation_p.R278W|LRRC32_uc010rsf.1_Missense_Mutation_p.R278W	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	278	LRR 10.|Extracellular (Potential).					integral to plasma membrane					0						GTGGGGAGCCGGATGAGGTTG	0.652													A	76371805	A	A	76371805	3	1	89	1	0	0	0	0	1	0	0	0	8987	1115	39	2	1160	2	LRRC32	11	76371805	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	75088285	76371805	58634711	43	5975											
GRAMD1B	57476	broad.mit.edu	37	chr11	123485469	123485469	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaggttccacacagacgcgGcatatcccggaggacacccc	10	16	0	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr11:123485469G>A	uc001pyx.2	+	16	2144	c.1815G>A	c.(1813-1815)CGG>CGA	p.R605R	GRAMD1B_uc001pyw.2_Silent_p.R612R|GRAMD1B_uc010rzw.1_Silent_p.R565R|GRAMD1B_uc010rzx.1_Silent_p.R565R|GRAMD1B_uc001pyy.2_Silent_p.R296R	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	605						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		CACAGACGCGGCATATCCCGG	0.537													A	123485469	A	A	123485469	2	1	89	1	0	0	0	0	0	0	0	1	6748	1190	42	3		3	GRAMD1B	11	123485469	Silent	SNP	G	TCGA-06-5412-01A-01D-1696-08	47113664	123485469	11521047	44	5976											
DDX11	1663	broad.mit.edu	37	chr12	31236988	31236988	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agagagggacctggtggaccGactaaaggtgagacctgggg	18	7	0	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr12:31236988G>T	uc001rjt.1	+	3	637	c.386G>T	c.(385-387)CGA>CTA	p.R129L	DDX11_uc010sjw.1_Missense_Mutation_p.R129L|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Missense_Mutation_p.R129L|DDX11_uc001rjs.1_Missense_Mutation_p.R129L|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.R129L|DDX11_uc001rjw.1_Missense_Mutation_p.R103L	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	129	Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CTGGTGGACCGACTAAAGGTG	0.587										Multiple Myeloma(12;0.14)			T	31236988	T	T	31236988	3	4	89	1	0	0	0	0	1	0	0	0	4343	1058	37	5	392	5	DDX11	12	31236988	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08		31236988	102614907	45	5977											
PTPN11	5781	broad.mit.edu	37	chr12	112926909	112926909	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gatggtccagacagaagcacAgtaccgatttatctatatgg	10	8	1	2	rs121918470		TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr12:112926909A>T	uc001ttx.2	+	13	1909	c.1529A>T	c.(1528-1530)CAG>CTG	p.Q510L		NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	514	Tyrosine-protein phosphatase.		Q -> P (in LEOPARD1).		axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding	p.Q510K(2)|p.Q510H(1)		haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						ACAGAAGCACAGTACCGATTT	0.498			Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				T	112926909	T	T	112926909	3	4	89	1	0	0	0	0	1	0	0	0	12780	188	7	5	1579	5	PTPN11	12	112926909	Missense_Mutation	SNP	A	TCGA-06-5412-01A-01D-1696-08	81689921	112926909	20924986	46	5978											
DIAPH3	81624	broad.mit.edu	37	chr13	60686198	60686198	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tctgacagtggctttggaaaGttctccatcatctctaaagg	9	9	4	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr13:60686198G>T	uc001vht.2	-	3	555	c.336C>A	c.(334-336)AAC>AAA	p.N112K	DIAPH3_uc001vhw.1_Missense_Mutation_p.N101K|DIAPH3_uc010aed.1_Missense_Mutation_p.N101K|DIAPH3_uc010aee.1_Intron	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	112					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GCTTTGGAAAGTTCTCCATCA	0.403													T	60686198	T	T	60686198	3	4	89	1	0	0	0	0	1	0	0	0	4520	1020	36	5	3369	5	DIAPH3	13	60686198	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08		60686198	54483680	47	5979											
MAP3K9	4293	broad.mit.edu	37	chr14	71205013	71205013	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagcgtccctggcccccacGtccgtcccttcttctttggg	9	18	2	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr14:71205013G>A	uc001xmm.2	-	8	1793	c.1793C>T	c.(1792-1794)ACG>ATG	p.T598M	MAP3K9_uc010ttk.1_Missense_Mutation_p.T335M|MAP3K9_uc001xmk.2_Missense_Mutation_p.T340M|MAP3K9_uc001xml.2_Missense_Mutation_p.T598M	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	598					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TGGCCCCCACGTCCGTCCCTT	0.488													A	71205013	A	A	71205013	3	1	89	1	0	0	0	0	1	0	0	0	9257	1145	40	1	1587	1	MAP3K9	14	71205013	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08		71205013	36144527	48	5980											
AHSA1	10598	broad.mit.edu	37	chr14	77930956	77930956	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttcagagttcacccagggcaTgatcttacctacaatgaatg	8	10	3	3			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr14:77930956T>A	uc001xtw.2	+	5	648	c.488T>A	c.(487-489)ATG>AAG	p.M163K	AHSA1_uc010tvk.1_Missense_Mutation_p.M163K	NM_012111	NP_036243	O95433	AHSA1_HUMAN	activator of heat shock 90kDa protein ATPase	163					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		ACCCAGGGCATGATCTTACCT	0.468													A	77930956	A	A	77930956	3	1	89	1	0	0	0	0	1	0	0	0	418	1464	51	5	506	5	AHSA1	14	77930956	Missense_Mutation	SNP	T	TCGA-06-5412-01A-01D-1696-08	6725943	77930956	29418584	49	5981			1	22		2	2	42	N	T_G	9.800294e-05
AHSA1	10598	broad.mit.edu	37	chr14	77930997	77930997	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagagtcagtagacccagtgGggcagccagcactgaaaact	13	10	1	3			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr14:77930997G>A	uc001xtw.2	+	5	689	c.529G>A	c.(529-531)GGG>AGG	p.G177R	AHSA1_uc010tvk.1_Missense_Mutation_p.G177R	NM_012111	NP_036243	O95433	AHSA1_HUMAN	activator of heat shock 90kDa protein ATPase	177					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		AGACCCAGTGGGGCAGCCAGC	0.473													A	77930997	A	A	77930997	3	1	89	1	0	0	0	0	1	0	0	0	418	1232	43	3	547	3	AHSA1	14	77930997	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	41	77930997	29418543	50	5982			1	22		2	2	42	N	T_G	9.800294e-05
RPS6KA5	9252	broad.mit.edu	37	chr14	91372576	91372576	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggatctttcatcaaaagacGctgaattaggtctttcgcta	9	8	4	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr14:91372576G>A	uc001xys.2	-	8	1089	c.874C>T	c.(874-876)CGT>TGT	p.R292C	RPS6KA5_uc010twi.1_Missense_Mutation_p.R213C|RPS6KA5_uc001xyt.2_Missense_Mutation_p.R292C|RPS6KA5_uc010att.1_RNA	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	292	Protein kinase 1.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		ATCAAAAGACGCTGAATTAGG	0.383													A	91372576	A	A	91372576	3	1	89	1	0	0	0	0	1	0	0	0	13654	1087	38	1	1580	1	RPS6KA5	14	91372576	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	13441579	91372576	15976964	51	5983											
SENP8	123228	broad.mit.edu	37	chr15	72432087	72432090	+	Frame_Shift_Del	DEL	CAGT	-	-													gcgtttgagtactttgccaaCagtcagtttcatgactgctc							TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr15:72432087_72432090delCAGT	uc002atp.2	+	2	222_225	c.123_126delCAGT	c.(121-126)AACAGTfs	p.N41fs		NM_145204	NP_660205	Q96LD8	SENP8_HUMAN	SUMO/sentrin specific peptidase family member 8	41_42	Protease.				proteolysis		cysteine-type peptidase activity|protein binding			ovary(1)|skin(1)	2						ACTTTGCCAACAGTCAGTTTCATG	0.475													-	72432090	-	-	72432087	7	5	89	1	0	1	0	1	0	0	0	0	14052	477	17	0	125	0	SENP8	15	72432087	Frame_Shift_Del	DEL	CAGT	TCGA-06-5412-01A-01D-1696-08		72432087	30099305	52	5984											
RHBDL1	9028	broad.mit.edu	37	chr16	726867	726867	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgcagctgcccaccccccGtgttcatggcctcggtcact	9	19	2	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr16:726867G>A	uc002cis.1	+	2	619	c.592G>A	c.(592-594)GTG>ATG	p.V198M	RHBDL1_uc002cir.1_Missense_Mutation_p.V133M|RHBDL1_uc010uun.1_Missense_Mutation_p.V133M	NM_003961	NP_003952	O75783	RHBL1_HUMAN	rhomboid protease 1	198	Helical; (Potential).				proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)				CCCACCCCCCGTGTTCATGGC	0.667													A	726867	A	A	726867	3	1	89	1	0	0	0	0	1	0	0	0	13321	1145	40	1	598	1	RHBDL1	16	726867	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08		726867	89627886	53	5985											
NOD2	64127	broad.mit.edu	37	chr16	50733737	50733737	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cccgagacctgcagagtcacCggccagccattgtcaggagg	13	14	2	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr16:50733737C>G	uc002egm.1	+	2	517	c.412C>G	c.(412-414)CGG>GGG	p.R138G	NOD2_uc010cbj.1_Missense_Mutation_p.R111G|NOD2_uc010cbk.1_Missense_Mutation_p.R111G|NOD2_uc002egl.1_5'UTR	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	138	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				GCAGAGTCACCGGCCAGCCAT	0.632													G	50733737	G	G	50733737	3	3	89	1	0	0	0	0	1	0	0	0	10517	643	23	5	418	5	NOD2	16	50733737	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	50006870	50733737	39621016	54	5986											
GPR56	9289	broad.mit.edu	37	chr16	57688009	57688009	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaagctccagcccacagcCggcctccaggacctgcacat	10	17	0	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr16:57688009C>T	uc002emb.2	+	6	1024	c.732C>T	c.(730-732)GCC>GCT	p.A244A	GPR56_uc002elz.1_Silent_p.A74A|GPR56_uc002ema.1_Silent_p.A69A|GPR56_uc002emc.2_Silent_p.A244A|GPR56_uc002emf.2_Silent_p.A244A|GPR56_uc010vhs.1_Silent_p.A244A|GPR56_uc002emd.2_Silent_p.A244A|GPR56_uc002eme.2_Silent_p.A244A|GPR56_uc010vht.1_Silent_p.A249A|GPR56_uc002emg.3_Silent_p.A244A|GPR56_uc010vhu.1_Silent_p.A69A	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	244	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						AGCCCACAGCCGGCCTCCAGG	0.662													T	57688009	T	T	57688009	2	4	89	1	0	0	0	0	0	0	0	1	6700	639	23	2		2	GPR56	16	57688009	Silent	SNP	C	TCGA-06-5412-01A-01D-1696-08	6954272	57688009	32666744	55	5987											
NF1	4763	broad.mit.edu	37	chr17	29652976	29652979	+	Frame_Shift_Del	DEL	TCTC	-	-													aatcgctttaaaacagacttTctctctaagtggtttgttgt							TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr17:29652976_29652979delTCTC	uc002hgg.2	+	37	5307_5310	c.4974_4977delTCTC	c.(4972-4977)TTTCTCfs	p.F1658fs	NF1_uc002hgh.2_Frame_Shift_Del_p.F1637fs|NF1_uc002hgi.1_Frame_Shift_Del_p.F670fs|NF1_uc010cso.2_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1658_1659	CRAL-TRIO.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.S1660fs*37(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AAACAGACTTTCTCTCTAAGTGGT	0.422			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29652979	-	-	29652976	7	5	89	1	0	1	0	1	0	0	0	0	10356	1780	62	0	5181	0	NF1	17	29652976	Frame_Shift_Del	DEL	TCTC	TCGA-06-5412-01A-01D-1696-08		29652976	51542234	56	5988											
KRT35	3886	broad.mit.edu	37	chr17	39637191	39637191	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctgcttctgcccagacccacTgagcaggcagagaaacttct	9	14	2	3			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr17:39637191T>A	uc002hws.2	-	1	202	c.159A>T	c.(157-159)TCA>TCT	p.S53S		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	53	Head.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				CCAGACCCACTGAGCAGGCAG	0.632													A	39637191	A	A	39637191	2	1	89	1	0	0	0	0	0	0	0	1	8472	1567	55	5		5	KRT35	17	39637191	Silent	SNP	T	TCGA-06-5412-01A-01D-1696-08	9984215	39637191	41558019	57	5989											
PTPRM	5797	broad.mit.edu	37	chr18	8244151	8244151	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagagctatgctgagcaggGcacaaactgcgacgaggctt	13	10	0	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr18:8244151G>A	uc002knn.3	+	15	2899	c.2396G>A	c.(2395-2397)GGC>GAC	p.G799D	PTPRM_uc010dkv.2_Missense_Mutation_p.G799D|PTPRM_uc010wzl.1_Missense_Mutation_p.G586D	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	799	Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCTGAGCAGGGCACAAACTGC	0.483													A	8244151	A	A	8244151	3	1	89	1	0	0	0	0	1	0	0	0	12806	1203	42	3	2454	3	PTPRM	18	8244151	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08		8244151	69833097	58	5990											
PPP4R1	9989	broad.mit.edu	37	chr18	9570482	9570482	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcattactagctgcttcctGgtgagattctgaggacaaag	10	9	2	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr18:9570482G>A	uc002koe.1	-	11	1364	c.1246C>T	c.(1246-1248)CAG>TAG	p.Q416*	PPP4R1_uc002kof.2_5'UTR|PPP4R1_uc010wzo.1_Nonsense_Mutation_p.Q262*|PPP4R1_uc002kod.1_Nonsense_Mutation_p.Q399*|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	416					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						GCTGCTTCCTGGTGAGATTCT	0.443													A	9570482	A	A	9570482	4	1	89	1	0	0	0	0	0	1	0	0	12403	1357	47	3	1646	3	PPP4R1	18	9570482	Nonsense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	1326331	9570482	68506766	59	5991											
NPC1	4864	broad.mit.edu	37	chr18	21120489	21120489	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgaatgacagaacacccaCaaatattgctatctggaaca	7	10	1	3			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr18:21120489C>T	uc002kum.3	-	17	2801	c.2527G>A	c.(2527-2529)GTG>ATG	p.V843M	NPC1_uc010xaz.1_Missense_Mutation_p.V576M|NPC1_uc010xba.1_Missense_Mutation_p.V688M	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	843	Helical; (Potential).				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGAACACCCACAAATATTGCT	0.363													T	21120489	T	T	21120489	3	4	89	1	0	0	0	0	1	0	0	0	10570	478	17	3	1345	3	NPC1	18	21120489	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	11550007	21120489	56956759	60	5992											
KIAA1012	22878	broad.mit.edu	37	chr18	29487454	29487454	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcataaagcattgcttgaTcattaagaaaatctttcttt	5	7	3	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr18:29487454T>G	uc002kxc.3	-	9	1722	c.1358A>C	c.(1357-1359)GAT>GCT	p.D453A	KIAA1012_uc002kxb.3_Missense_Mutation_p.D399A|KIAA1012_uc002kxd.3_RNA|KIAA1012_uc002kxe.2_Missense_Mutation_p.D453A	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	453					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						CATTGCTTGATCATTAAGAAA	0.338													G	29487454	G	G	29487454	3	3	89	1	0	0	0	0	1	0	0	0	8204	1435	50	5	3033	5	KIAA1012	18	29487454	Missense_Mutation	SNP	T	TCGA-06-5412-01A-01D-1696-08	8366965	29487454	48589794	61	5993											
CREB3L3	84699	broad.mit.edu	37	chr19	4164609	4164609	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctggctaaagaaggcatcaCcctgcccactcagctgcccc	9	17	2	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr19:4164609C>T	uc002lzl.2	+	5	802	c.686C>T	c.(685-687)ACC>ATC	p.T229I	CREB3L3_uc002lzm.2_Missense_Mutation_p.T219I|CREB3L3_uc010xib.1_Missense_Mutation_p.T218I|CREB3L3_uc010xic.1_Missense_Mutation_p.T220I	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	229	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGGCATCACCCTGCCCACT	0.617													T	4164609	T	T	4164609	3	4	89	1	0	0	0	0	1	0	0	0	3858	507	18	3	704	3	CREB3L3	19	4164609	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08		4164609	54964374	62	5994											
DNAJB1	3337	broad.mit.edu	37	chr19	14627500	14627500	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgctctttccgtcggggttTagccgcttgtgggagatttt	13	8	1	1	rs143985567	byFrequency	TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr19:14627500T>C	uc002myz.1	-	2	610	c.570A>G	c.(568-570)CTA>CTG	p.L190L	DNAJB1_uc010xnr.1_Silent_p.L90L	NM_006145	NP_006136	P25685	DNJB1_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 1	190					chaperone cofactor-dependent protein refolding|response to unfolded protein	cytoplasm|nucleolus	heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(1328;0.0476)		CGTCGGGGTTTAGCCGCTTGT	0.483													C	14627500	C	C	14627500	2	2	89	1	0	0	0	0	0	0	0	1	4615	1741	61	4		4	DNAJB1	19	14627500	Silent	SNP	T	TCGA-06-5412-01A-01D-1696-08	10462891	14627500	44501483	63	5995											
NOP56	10528	broad.mit.edu	37	chr20	2633552	2633552	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gctggcgctgaaggaagtggAggagatcagtctgctgcagc	17	8	2	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr20:2633552A>T	uc002wgh.2	+	2	121	c.68A>T	c.(67-69)GAG>GTG	p.E23V	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_5'Flank|SNORD110_uc002wgj.2_5'Flank|SNORA51_uc002wgk.1_5'Flank|NOP56_uc002wgm.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	23					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						AAGGAAGTGGAGGAGATCAGT	0.677													T	2633552	T	T	2633552	3	4	89	1	0	0	0	0	1	0	0	0	10539	304	11	5	74	5	NOP56	20	2633552	Missense_Mutation	SNP	A	TCGA-06-5412-01A-01D-1696-08		2633552	60391968	64	5996											
LBP	3929	broad.mit.edu	37	chr20	36992652	36992652	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacagagattgacagtttcGccgacattgattatagctta	8	8	0	3			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr20:36992652G>A	uc002xic.1	+	7	711	c.676G>A	c.(676-678)GCC>ACC	p.A226T		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	226					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				TGACAGTTTCGCCGACATTGA	0.562													A	36992652	A	A	36992652	3	1	89	1	0	0	0	0	1	0	0	0	8651	1087	38	1	702	1	LBP	20	36992652	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	34359100	36992652	26032868	65	5997											
WFDC9	259240	broad.mit.edu	37	chr20	44237357	44237357	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcatgtatgatttggacGtacacaagtcattattttag	9	6	1	1	rs139643257	byFrequency	TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr20:44237357G>A	uc002xoy.2	-	4	402	c.184C>T	c.(184-186)CGT>TGT	p.R62C		NM_147198	NP_671731	Q8NEX5	WFDC9_HUMAN	protease inhibitor WAP9 precursor	62						extracellular region					0		Myeloproliferative disorder(115;0.0122)				TGATTTGGACGTACACAAGTC	0.453													A	44237357	A	A	44237357	3	1	89	1	0	0	0	0	1	0	0	0	17354	1145	40	1	93	1	WFDC9	20	44237357	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	7244705	44237357	18788163	66	5998											
TP53RK	112858	broad.mit.edu	37	chr20	45315631	45315631	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gagcacaatgttcagctgttCcagggggggtttcaggagca	15	8	2	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr20:45315631C>A	uc002xsk.2	-	2	746	c.523G>T	c.(523-525)GAA>TAA	p.E175*	SLC13A3_uc002xsg.1_5'Flank|SLC13A3_uc010gho.1_5'Flank|TP53RK_uc002xsj.2_3'UTR	NM_033550	NP_291028	Q96S44	PRPK_HUMAN	p53-related protein kinase	175	Protein kinase.				lipopolysaccharide biosynthetic process	membrane|nucleus	ATP binding|p53 binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Myeloproliferative disorder(115;0.0122)				TTCAGCTGTTCCAGGGGGGGT	0.498													A	45315631	A	A	45315631	4	1	89	1	0	0	0	0	0	1	0	0	16387	864	30	5	242	5	TP53RK	20	45315631	Nonsense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	1078274	45315631	17709889	67	5999											
SFRS15	57466	broad.mit.edu	37	chr21	33074598	33074598	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctactggggctgcattaCtggttcccgctgccatgtcc	11	14	0	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chr21:33074598C>T	uc002ypd.2	-	5	842	c.416G>A	c.(415-417)AGT>AAT	p.S139N	SFRS15_uc002ype.2_Missense_Mutation_p.S139N|SFRS15_uc010glu.2_Missense_Mutation_p.S124N|SFRS15_uc002ypf.1_5'Flank|SFRS15_uc002ypg.2_Missense_Mutation_p.S139N	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	139	CID.					nucleus	nucleotide binding|RNA binding				0						GGCTGCATTACTGGTTCCCGC	0.388													T	33074598	T	T	33074598	3	4	89	1	0	0	0	0	1	0	0	0	14171	565	20	3	3091	3	SFRS15	21	33074598	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08		33074598	15055297	68	6000											
VCX3B	425054	broad.mit.edu	37	chrX	8433593	8433593	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccagtgacccgaagaagaaGgtgagtgaccctcccaagct	11	13	0	5			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chrX:8433593G>C	uc010ndo.2	+	2	409	c.102G>C	c.(100-102)AAG>AAC	p.K34N	VCX3B_uc011mht.1_Missense_Mutation_p.K34N|VCX3B_uc004csd.1_Missense_Mutation_p.K34N	NM_001001888	NP_001001888	Q9H321	VCX3B_HUMAN	variable charge, X-linked 3B	34						nucleolus					0						CGAAGAAGAAGGTGAGTGACC	0.632													C	8433593	C	C	8433593	3	2	89	1	0	0	0	0	1	0	0	0	17142	1014	35	5	104	5	VCX3B	23	8433593	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08		8433593	146836967	69	6001											
USP9X	8239	broad.mit.edu	37	chrX	41075424	41075424	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatacagacttgtgggtgtGctcgtacacagtggtcaagc	12	8	1	1			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chrX:41075424G>A	uc004dfb.2	+	35	6237	c.5604G>A	c.(5602-5604)GTG>GTA	p.V1868V	USP9X_uc004dfc.2_Silent_p.V1868V	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1868					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTGTGGGTGTGCTCGTACACA	0.448													A	41075424	A	A	41075424	2	1	89	1	0	0	0	0	0	0	0	1	17087	1306	46	3		3	USP9X	23	41075424	Silent	SNP	G	TCGA-06-5412-01A-01D-1696-08	32641831	41075424	114195136	70	6002											
TEX11	56159	broad.mit.edu	37	chrX	69902635	69902635	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attttccgatgacttaaaacGttcatgaataatcgtcagga	7	7	2	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chrX:69902635G>A	uc004dyl.2	-	15	1252	c.1090C>T	c.(1090-1092)CGT>TGT	p.R364C	TEX11_uc004dyk.2_Missense_Mutation_p.R39C|TEX11_uc004dym.2_Missense_Mutation_p.R349C	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	364							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					GACTTAAAACGTTCATGAATA	0.358													A	69902635	A	A	69902635	3	1	89	1	0	0	0	0	1	0	0	0	15771	1145	40	1	1800	1	TEX11	23	69902635	Missense_Mutation	SNP	G	TCGA-06-5412-01A-01D-1696-08	28827211	69902635	85367925	71	6003											
FHL1	2273	broad.mit.edu	37	chrX	135291466	135291466	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggaagcccccagtgtgccaCgggaaacgcttgcctctcac	11	15	1	0			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chrX:135291466C>T	uc004ezo.2	+	6	853	c.753C>T	c.(751-753)CAC>CAT	p.H251H	FHL1_uc010nrz.2_Intron|FHL1_uc004ezm.2_Intron|FHL1_uc004ezl.2_Intron|FHL1_uc004ezq.2_Intron|FHL1_uc011mvy.1_Intron|FHL1_uc011mvz.1_Intron|FHL1_uc004ezn.2_Intron|FHL1_uc011mwa.1_Intron|FHL1_uc011mwb.1_Intron|FHL1_uc004ezp.2_Intron|FHL1_uc004ezr.2_Intron	NM_001159702	NP_001153174	Q13642	FHL1_HUMAN	four and a half LIM domains 1 isoform 1	251					cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)					CAGTGTGCCACGGGAAACGCT	0.552											OREG0019943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	135291466	T	T	135291466	2	4	89	1	0	0	0	0	0	0	0	1	5878	535	19	1		1	FHL1	23	135291466	Silent	SNP	C	TCGA-06-5412-01A-01D-1696-08	65388831	135291466	19979094	72	6004											
SLITRK2	84631	broad.mit.edu	37	chrX	144905002	144905002	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acctctcagagctcagacaaTggtctgaatgtaaactgcca	8	11	3	3			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chrX:144905002T>C	uc004fcd.2	+	5	2049	c.1059T>C	c.(1057-1059)AAT>AAC	p.N353N	SLITRK2_uc010nsp.2_Silent_p.N353N|SLITRK2_uc010nso.2_Silent_p.N353N|SLITRK2_uc011mwq.1_Silent_p.N353N|SLITRK2_uc011mwr.1_Silent_p.N353N|SLITRK2_uc011mws.1_Silent_p.N353N|SLITRK2_uc004fcg.2_Silent_p.N353N|SLITRK2_uc011mwt.1_Silent_p.N353N	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	353	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCAGACAATGGTCTGAATG	0.493													C	144905002	C	C	144905002	2	2	89	1	0	0	0	0	0	0	0	1	14743	1461	51	4		4	SLITRK2	23	144905002	Silent	SNP	T	TCGA-06-5412-01A-01D-1696-08	9613536	144905002	10365558	73	6005											
PLXNA3	55558	broad.mit.edu	37	chrX	153689599	153689599	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccagcagacgctgttggacaCagcgggcgagaaatttttca	12	10	1	2			TCGA-06-5412-01A-01D-1696-08	TCGA-06-5412-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b6be0866-b8ae-4767-8cdc-e1dd4f78f440	4cb53c96-2d07-4a8e-9749-89a4d29acc17	g.chrX:153689599C>A	uc004flm.2	+	3	928	c.755C>A	c.(754-756)ACA>AAA	p.T252K		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	252	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGTTGGACACAGCGGGCGAG	0.567													A	153689599	A	A	153689599	3	1	89	1	0	0	0	0	1	0	0	0	12121	478	17	5	761	5	PLXNA3	23	153689599	Missense_Mutation	SNP	C	TCGA-06-5412-01A-01D-1696-08	8784597	153689599	1580961	74	6006											
KIAA1751	85452	broad.mit.edu	37	chr1	1918455	1918455	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gatcaggtcccgcctctgccGacaggcgcgcagctcccctc	11	19	2	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr1:1918455G>A	uc001aim.1	-	5	472	c.316C>T	c.(316-318)CGG>TGG	p.R106W	KIAA1751_uc009vkz.1_Missense_Mutation_p.R106W|KIAA1751_uc001ain.1_Missense_Mutation_p.R106W	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	106										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CGCCTCTGCCGACAGGCGCGC	0.632													A	1918455	A	A	1918455	3	1	90	1	0	0	0	0	1	0	0	0	8256	1057	37	2	2028	2	KIAA1751	1	1918455	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08		1918455	247332166	1	6007											
EIF4G3	8672	broad.mit.edu	37	chr1	21268743	21268743	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttcagatgtctggccttcttGttctttcttctctccactga	6	12	6	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr1:21268743G>C	uc001bec.2	-	9	992	c.736C>G	c.(736-738)CAA>GAA	p.Q246E	EIF4G3_uc010odi.1_5'UTR|EIF4G3_uc010odj.1_Missense_Mutation_p.Q245E|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Missense_Mutation_p.Q246E|EIF4G3_uc001bef.2_Missense_Mutation_p.Q245E|EIF4G3_uc001bee.2_Missense_Mutation_p.Q252E|EIF4G3_uc001beg.2_Missense_Mutation_p.Q245E|EIF4G3_uc010odk.1_Missense_Mutation_p.Q246E|EIF4G3_uc001beh.2_Missense_Mutation_p.Q257E	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	246					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TGGCCTTCTTGTTCTTTCTTC	0.448													C	21268743	C	C	21268743	3	2	90	1	0	0	0	0	1	0	0	0	5038	1386	48	5	4117	5	EIF4G3	1	21268743	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	19350288	21268743	227981878	2	6008											
RPL5	6125	broad.mit.edu	37	chr1	93298955	93298955	+	Frame_Shift_Del	DEL	A	-	-													ttttctttaaggggtttgttAaagttgttaagaataaggcc							TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr1:93298955delA	uc001doz.2	+	2	91	c.13delA	c.(13-15)AAAfs	p.K5fs	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_RNA|RPL5_uc001dpb.2_5'UTR|RPL5_uc001dpd.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5	5					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		GGGGTTTGTTAAAGTTGTTAA	0.299													-	93298955	-	-	93298955	7	5	90	1	0	1	0	1	0	0	0	0	13597	363	13	0	19	0	RPL5	1	93298955	Frame_Shift_Del	DEL	A	TCGA-06-5413-01A-01D-1696-08	72030212	93298955	155951666	3	6009											
OVGP1	5016	broad.mit.edu	37	chr1	111957411	111957411	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggggacagtcaccttttcaCgggccacagccttccttcta	9	14	3	0	rs150120731	byFrequency	TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr1:111957411C>T	uc001eba.2	-	11	1768	c.1712G>A	c.(1711-1713)CGT>CAT	p.R571H	OVGP1_uc001eaz.2_Missense_Mutation_p.R533H|OVGP1_uc010owb.1_Missense_Mutation_p.R219H	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	571					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CACCTTTTCACGGGCCACAGC	0.527													T	111957411	T	T	111957411	3	4	90	1	0	0	0	0	1	0	0	0	11325	536	19	1	328	1	OVGP1	1	111957411	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	18658456	111957411	137293210	4	6010											
SH2D1B	117157	broad.mit.edu	37	chr1	162368789	162368789	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctttattggctttaaaaggTgaaccaccatcccctgattt	6	10	1	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr1:162368789T>C	uc001gbz.1	-	3	409	c.287A>G	c.(286-288)CAC>CGC	p.H96R	SH2D1B_uc001gca.1_Intron	NM_053282	NP_444512	O14796	SH21B_HUMAN	SH2 domain containing 1B	96	SH2.									pancreas(1)	1	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			CTTTAAAAGGTGAACCACCAT	0.423													C	162368789	C	C	162368789	3	2	90	1	0	0	0	0	1	0	0	0	14231	1696	59	4	119	4	SH2D1B	1	162368789	Missense_Mutation	SNP	T	TCGA-06-5413-01A-01D-1696-08	50411378	162368789	86881832	5	6011											
RYR2	6262	broad.mit.edu	37	chr1	237947200	237947200	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcactacacgcagtcagaaaCggaatttcttttgtcttgtg	9	9	3	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr1:237947200C>T	uc001hyl.1	+	90	12308	c.12188C>T	c.(12187-12189)ACG>ATG	p.T4063M	RYR2_uc010pya.1_Missense_Mutation_p.T478M	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4063					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGTCAGAAACGGAATTTCTT	0.483													T	237947200	T	T	237947200	3	4	90	1	0	0	0	0	1	0	0	0	13769	536	19	1	12546	1	RYR2	1	237947200	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	75578411	237947200	11303421	6	6012											
OR2T3	343173	broad.mit.edu	37	chr1	248637275	248637275	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acgctcatgtacctgtgctgCatcctcatgcttctcgcccc	7	17	3	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr1:248637275C>A	uc001iel.1	+	1	624	c.624C>A	c.(622-624)TGC>TGA	p.C208*		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTGTGCTGCATCCTCATGC	0.532													A	248637275	A	A	248637275	4	1	90	1	0	0	0	0	0	1	0	0	11023	718	25	5	626	5	OR2T3	1	248637275	Nonsense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	10690075	248637275	613346	7	6013											
APOB	338	broad.mit.edu	37	chr2	21228712	21228712	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcttgtcatagactggtagGatgatatttttgaggaacct	10	6	2	3			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr2:21228712G>A	uc002red.2	-	26	11156	c.11028C>T	c.(11026-11028)ATC>ATT	p.I3676I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3676					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGACTGGTAGGATGATATTTT	0.453													A	21228712	A	A	21228712	2	1	90	1	0	0	0	0	0	0	0	1	785	1164	41	3		3	APOB	2	21228712	Silent	SNP	G	TCGA-06-5413-01A-01D-1696-08		21228712	221970661	8	6014											
NLRC4	58484	broad.mit.edu	37	chr2	32460481	32460481	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtacctacctaaaattctaAtctctgtatctgtgagtctc	5	10	4	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr2:32460481A>C	uc002roi.2	-	8	3017	c.2771T>G	c.(2770-2772)ATT>AGT	p.I924S	NLRC4_uc002roj.1_Missense_Mutation_p.I924S|NLRC4_uc010ezt.1_Missense_Mutation_p.I259S	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	924	LRR 11.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TAAAATTCTAATCTCTGTATC	0.428													C	32460481	C	C	32460481	3	2	90	1	0	0	0	0	1	0	0	0	10469	101	4	5	311	5	NLRC4	2	32460481	Missense_Mutation	SNP	A	TCGA-06-5413-01A-01D-1696-08	11231769	32460481	210738892	9	6015											
CEP68	23177	broad.mit.edu	37	chr2	65296848	65296848	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtgatgccaacagagagccCgtagctgagaggtctgagcc	14	10	1	4	rs112673076		TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr2:65296848C>A	uc002sdl.3	+	2	484	c.270C>A	c.(268-270)CCC>CCA	p.P90P	CEP68_uc002sdj.2_Silent_p.P90P|CEP68_uc010yqb.1_Silent_p.P90P|CEP68_uc002sdk.3_Silent_p.P90P|CEP68_uc010yqc.1_Silent_p.P90P|CEP68_uc010yqd.1_Silent_p.P90P	NM_015147	NP_055962	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	90					centrosome organization	centrosome				skin(1)	1						ACAGAGAGCCCGTAGCTGAGA	0.627													A	65296848	A	A	65296848	2	1	90	1	0	0	0	0	0	0	0	1	3258	639	23	5		5	CEP68	2	65296848	Silent	SNP	C	TCGA-06-5413-01A-01D-1696-08	32836367	65296848	177902525	10	6016											
FAM123C	205147	broad.mit.edu	37	chr2	131520873	131520873	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagcccaggcactcctgccGccaccttcccacgggacagc	10	19	0	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr2:131520873G>A	uc002trw.2	+	2	1418	c.1228G>A	c.(1228-1230)GCC>ACC	p.A410T	FAM123C_uc010fmv.2_Missense_Mutation_p.A410T|FAM123C_uc010fms.1_Missense_Mutation_p.A410T|FAM123C_uc010fmt.1_Missense_Mutation_p.A410T|FAM123C_uc010fmu.1_Missense_Mutation_p.A410T	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	410										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CACTCCTGCCGCCACCTTCCC	0.617													A	131520873	A	A	131520873	3	1	90	1	0	0	0	0	1	0	0	0	5424	1087	38	1	1230	1	FAM123C	2	131520873	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	66224025	131520873	111678500	11	6017											
SCN3A	6328	broad.mit.edu	37	chr2	165997260	165997260	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgctgtgcatcttcccattTgctggaagccctggcaccat	10	13	1	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr2:165997260T>C	uc002ucx.2	-	13	2412	c.1920A>G	c.(1918-1920)GCA>GCG	p.A640A	SCN3A_uc002ucy.2_Intron|SCN3A_uc002ucz.2_Intron|SCN3A_uc002uda.1_Intron|SCN3A_uc002udb.1_Intron	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	640						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TCTTCCCATTTGCTGGAAGCC	0.542													C	165997260	C	C	165997260	2	2	90	1	0	0	0	0	0	0	0	1	13918	1799	63	4		4	SCN3A	2	165997260	Silent	SNP	T	TCGA-06-5413-01A-01D-1696-08	34476387	165997260	77202113	12	6018											
TTN	7273	broad.mit.edu	37	chr2	179647077	179647077	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttttgtaataaagtaaggcGcggcaggttctccaggccct	12	9	1	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr2:179647077G>A	uc010zfg.1	-	20	3466	c.3242C>T	c.(3241-3243)GCG>GTG	p.A1081V	TTN_uc010zfh.1_Missense_Mutation_p.A1035V|TTN_uc010zfi.1_Missense_Mutation_p.A1035V|TTN_uc010zfj.1_Missense_Mutation_p.A1035V|TTN_uc002unb.2_Missense_Mutation_p.A1081V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1081							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAGTAAGGCGCGGCAGGTTC	0.502													A	179647077	A	A	179647077	3	1	90	1	0	0	0	0	1	0	0	0	16732	1087	38	1	108118	1	TTN	2	179647077	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	13649817	179647077	63552296	13	6019											
MARS2	92935	broad.mit.edu	37	chr2	198570303	198570303	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctacgtgaacgcggcgccGcacatcgggcacctgtactc	11	15	1	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr2:198570303G>A	uc002uuq.2	+	1	217	c.174G>A	c.(172-174)CCG>CCA	p.P58P	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	58	HIGH region.				methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	ACGCGGCGCCGCACATCGGGC	0.642													A	198570303	A	A	198570303	2	1	90	1	0	0	0	0	0	0	0	1	9317	1074	38	1		1	MARS2	2	198570303	Silent	SNP	G	TCGA-06-5413-01A-01D-1696-08	18923226	198570303	44629070	14	6020											
HDLBP	3069	broad.mit.edu	37	chr2	242202197	242202197	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagctttcctgacaccatgaTggagaggccttggtctttgg	12	10	1	3			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr2:242202197T>C	uc002waz.2	-	5	607	c.379A>G	c.(379-381)ATC>GTC	p.I127V	HDLBP_uc002wba.2_Missense_Mutation_p.I127V|HDLBP_uc002wbb.2_Missense_Mutation_p.I148V|HDLBP_uc010fzn.1_Intron|uc010zoo.1_5'Flank	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	127					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		GACACCATGATGGAGAGGCCT	0.512													C	242202197	C	C	242202197	3	2	90	1	0	0	0	0	1	0	0	0	7025	1464	51	4	3523	4	HDLBP	2	242202197	Missense_Mutation	SNP	T	TCGA-06-5413-01A-01D-1696-08	43631894	242202197	997176	15	6021											
SLC6A20	54716	broad.mit.edu	37	chr3	45800488	45800488	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcaggccacggggtctgcGtctcccctcttgaggcgacg	13	15	4	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr3:45800488G>A	uc011bai.1	-	11	1885	c.1761C>T	c.(1759-1761)GAC>GAT	p.D587D	SLC6A20_uc003cow.2_Silent_p.D237D|SLC6A20_uc011baj.1_Silent_p.D550D	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	587	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CGGGGTCTGCGTCTCCCCTCT	0.577													A	45800488	A	A	45800488	2	1	90	1	0	0	0	0	0	0	0	1	14684	1136	40	1		1	SLC6A20	3	45800488	Silent	SNP	G	TCGA-06-5413-01A-01D-1696-08		45800488	152221942	16	6022											
NISCH	11188	broad.mit.edu	37	chr3	52525480	52525480	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggaacgcacgccctcgccGgagcctgttgacaaggactt	12	14	0	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr3:52525480G>A	uc011beg.1	+	21	3927	c.3855G>A	c.(3853-3855)CCG>CCA	p.P1285P	NISCH_uc003ded.3_Silent_p.P1285P|NISCH_uc003dee.3_Silent_p.P774P|NISCH_uc003deg.1_RNA|NISCH_uc003deh.3_Silent_p.P34P	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1285					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CGCCCTCGCCGGAGCCTGTTG	0.602													A	52525480	A	A	52525480	2	1	90	1	0	0	0	0	0	0	0	1	10432	1103	39	2		2	NISCH	3	52525480	Silent	SNP	G	TCGA-06-5413-01A-01D-1696-08	6724992	52525480	145496950	17	6023											
IL17RD	54756	broad.mit.edu	37	chr3	57132318	57132318	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggcgataaacttgctgagCgccgcggacgaactctgctt	12	12	1	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr3:57132318C>T	uc003dil.2	-	12	1502	c.1413G>A	c.(1411-1413)GCG>GCA	p.A471A	IL17RD_uc003dik.2_Silent_p.A447A|IL17RD_uc010hna.2_Silent_p.A327A|IL17RD_uc011bex.1_Silent_p.A327A	NM_017563	NP_060033	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D precursor	471	SEFIR.|Cytoplasmic (Potential).					Golgi membrane|integral to membrane|plasma membrane	receptor activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		ACTTGCTGAGCGCCGCGGACG	0.572													T	57132318	T	T	57132318	2	4	90	1	0	0	0	0	0	0	0	1	7642	755	27	1		1	IL17RD	3	57132318	Silent	SNP	C	TCGA-06-5413-01A-01D-1696-08	4606838	57132318	140890112	18	6024											
CD86	942	broad.mit.edu	37	chr3	121828238	121828238	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagaagaagaagcggcctcGcaactcttataaatgtggtg	12	7	1	3			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr3:121828238G>A	uc003eet.2	+	5	946	c.830G>A	c.(829-831)CGC>CAC	p.R277H	CD86_uc011bjo.1_Missense_Mutation_p.R195H|CD86_uc011bjp.1_Missense_Mutation_p.R165H|CD86_uc003eeu.2_Missense_Mutation_p.R271H	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	277	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	AAGCGGCCTCGCAACTCTTAT	0.468													A	121828238	A	A	121828238	3	1	90	1	0	0	0	0	1	0	0	0	3043	1087	38	1	848	1	CD86	3	121828238	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	64695920	121828238	76194192	19	6025											
PIK3CA	5290	broad.mit.edu	37	chr3	178916728	178916728	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgactttagaatgcctccgtGaggctacattaataaccata	7	9	0	3			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr3:178916728G>A	uc003fjk.2	+	2	272	c.115G>A	c.(115-117)GAG>AAG	p.E39K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	39	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E39K(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATGCCTCCGTGAGGCTACATT	0.388		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178916728	A	A	178916728	3	1	90	1	0	0	0	0	1	0	0	0	11913	1291	45	3	117	3	PIK3CA	3	178916728	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	57088490	178916728	19105702	20	6026											
SLC4A4	8671	broad.mit.edu	37	chr4	72399971	72399971	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccaaaccgaggttggttcGttccaccgtttggagaaaac	11	10	0	1	rs150967020		TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr4:72399971G>A	uc003hfy.2	+	18	2425	c.2308G>A	c.(2308-2310)GTT>ATT	p.V770I	SLC4A4_uc010iic.2_Missense_Mutation_p.V770I|SLC4A4_uc010iib.2_Missense_Mutation_p.V770I|SLC4A4_uc003hfz.2_Missense_Mutation_p.V770I|SLC4A4_uc003hgc.3_Missense_Mutation_p.V726I|SLC4A4_uc010iid.2_5'UTR	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	770	Interaction with CA4.|Extracellular (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AGGTTGGTTCGTTCCACCGTT	0.423													A	72399971	A	A	72399971	3	1	90	1	0	0	0	0	1	0	0	0	14656	1145	40	1	2495	1	SLC4A4	4	72399971	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08		72399971	118754305	21	6027											
PPEF2	5470	broad.mit.edu	37	chr4	76797822	76797822	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttgcacctcatggtggaaActatctaaacacgtccagaa	7	10	2	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr4:76797822A>G	uc003hix.2	-	11	1295	c.938T>C	c.(937-939)GTT>GCT	p.V313A	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.V313A	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	313	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CATGGTGGAAACTATCTAAAC	0.388													G	76797822	G	G	76797822	3	3	90	1	0	0	0	0	1	0	0	0	12308	43	2	4	1351	4	PPEF2	4	76797822	Missense_Mutation	SNP	A	TCGA-06-5413-01A-01D-1696-08	4397851	76797822	114356454	22	6028											
MAPK10	5602	broad.mit.edu	37	chr4	87028499	87028499	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtcaaggacagcatcataCgcggcactgtagagatccaa	10	11	2	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr4:87028499C>T	uc003hpq.2	-	4	310	c.243G>A	c.(241-243)GCG>GCA	p.A81A	MAPK10_uc010ikg.2_Silent_p.A43A|MAPK10_uc003hpr.2_Silent_p.A43A|MAPK10_uc003hps.2_Silent_p.A81A|MAPK10_uc003hpt.2_Silent_p.A81A|MAPK10_uc003hpu.2_Silent_p.A81A|MAPK10_uc003hpv.2_5'UTR|MAPK10_uc010ikh.1_RNA|MAPK10_uc003hpo.2_5'UTR|MAPK10_uc011ccw.1_5'UTR|MAPK10_uc003hpp.2_5'UTR	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	81	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		CAGCATCATACGCGGCACTGT	0.443													T	87028499	T	T	87028499	2	4	90	1	0	0	0	0	0	0	0	1	9272	523	19	1		1	MAPK10	4	87028499	Silent	SNP	C	TCGA-06-5413-01A-01D-1696-08	10230677	87028499	104125777	23	6029											
BBS12	166379	broad.mit.edu	37	chr4	123665161	123665161	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gataaattcacaggaattaaCgggctttctatttttgtagt	8	5	2	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr4:123665161C>T	uc003ieu.2	+	2	2307	c.2114C>T	c.(2113-2115)ACG>ATG	p.T705M		NM_152618	NP_689831	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	705					cellular protein metabolic process	cilium	ATP binding			ovary(2)	2						CAGGAATTAACGGGCTTTCTA	0.348									Bardet-Biedl_syndrome				T	123665161	T	T	123665161	3	4	90	1	0	0	0	0	1	0	0	0	1337	536	19	1	2116	1	BBS12	4	123665161	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	36636662	123665161	67489115	24	6030											
PLK4	10733	broad.mit.edu	37	chr4	128807278	128807278	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttacttcgtagaaatccagcAgatcgtttaagtctgtcttc	7	9	2	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr4:128807278A>T	uc003ifo.2	+	5	998	c.753A>T	c.(751-753)GCA>GCT	p.A251A	PLK4_uc011cgs.1_Silent_p.A219A|PLK4_uc011cgt.1_Silent_p.A210A	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	251	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						GAAATCCAGCAGATCGTTTAA	0.353													T	128807278	T	T	128807278	2	4	90	1	0	0	0	0	0	0	0	1	12098	175	7	5		5	PLK4	4	128807278	Silent	SNP	A	TCGA-06-5413-01A-01D-1696-08	5142117	128807278	62346998	25	6031											
NEK1	4750	broad.mit.edu	37	chr4	170398275	170398275	+	Frame_Shift_Del	DEL	T	-	-													taatatactactatacatacTttcagttgtagagaaggatg							TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr4:170398275delT	uc003isb.1	-	24	2842	c.2350delA	c.(2350-2352)AGAfs	p.R784fs	NEK1_uc003isc.1_Frame_Shift_Del_p.R740fs|NEK1_uc003isd.1_Frame_Shift_Del_p.R812fs|NEK1_uc003ise.1_Frame_Shift_Del_p.R768fs|NEK1_uc003isf.1_Frame_Shift_Del_p.R715fs	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	784					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		CTATACATACTTTCAGTTGTA	0.343													-	170398275	-	-	170398275	7	5	90	1	0	1	0	1	0	0	0	0	10321	1623	56	0	1470	0	NEK1	4	170398275	Frame_Shift_Del	DEL	T	TCGA-06-5413-01A-01D-1696-08	41590997	170398275	20756001	26	6032											
ADAMTS12	81792	broad.mit.edu	37	chr5	33549384	33549384	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgctcaatgggggaggaatGccggccaggaactggcagtg	17	8	1	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr5:33549384G>A	uc003jia.1	-	21	4393	c.4230C>T	c.(4228-4230)GGC>GGT	p.G1410G	ADAMTS12_uc010iuq.1_Silent_p.G1325G	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1410	TSP type-1 6.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGGGAGGAATGCCGGCCAGGA	0.612										HNSCC(64;0.19)			A	33549384	A	A	33549384	2	1	90	1	0	0	0	0	0	0	0	1	257	1306	46	3		3	ADAMTS12	5	33549384	Silent	SNP	G	TCGA-06-5413-01A-01D-1696-08		33549384	147365876	27	6033											
IL3	3562	broad.mit.edu	37	chr5	131396547	131396547	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taacacacttaaagcagccaCctttgcctttgctggtgagt	8	11	0	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr5:131396547C>T	uc003kwe.1	+	1	201	c.148C>T	c.(148-150)CCT>TCT	p.P50S		NM_000588	NP_000579	P08700	IL3_HUMAN	interleukin 3 precursor	50					cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			ovary(2)|central_nervous_system(1)	3		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)	AAAGCAGCCACCTTTGCCTTT	0.522													T	131396547	T	T	131396547	3	4	90	1	0	0	0	0	1	0	0	0	7689	507	18	3	150	3	IL3	5	131396547	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	97847163	131396547	49518713	28	6034											
FAT2	2196	broad.mit.edu	37	chr5	150947262	150947262	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggtggtgatcaacccagttcGagcattaagtttaaatccta	9	8	1	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr5:150947262G>A	uc003lue.3	-	1	1244	c.1231C>T	c.(1231-1233)CGA>TGA	p.R411*	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Nonsense_Mutation_p.R411*	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	411	Extracellular (Potential).|Cadherin 3.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACCCAGTTCGAGCATTAAGT	0.532													A	150947262	A	A	150947262	4	1	90	1	0	0	0	0	0	1	0	0	5690	1066	37	2	11910	2	FAT2	5	150947262	Nonsense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	19550715	150947262	29967998	29	6035											
BRPF3	27154	broad.mit.edu	37	chr6	36185728	36185728	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggaaaacacaccgaaagCgggtctgactctgaatgtag	11	8	2	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr6:36185728C>T	uc003olv.3	+	9	3248	c.3024C>T	c.(3022-3024)AGC>AGT	p.S1008S	BRPF3_uc010jwb.2_Silent_p.S738S|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Intron|BRPF3_uc010jwd.2_5'UTR	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	1008					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						ACACCGAAAGCGGGTCTGACT	0.512													T	36185728	T	T	36185728	2	4	90	1	0	0	0	0	0	0	0	1	1521	767	27	1		1	BRPF3	6	36185728	Silent	SNP	C	TCGA-06-5413-01A-01D-1696-08		36185728	134929339	30	6036											
LGSN	51557	broad.mit.edu	37	chr6	63990385	63990385	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaacagaaggcgccatcagGcagctgagcgcagcagagtg	14	11	1	3			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr6:63990385G>A	uc003peh.2	-	4	1105	c.1071C>T	c.(1069-1071)TGC>TGT	p.C357C	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	357					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	GCGCCATCAGGCAGCTGAGCG	0.498													A	63990385	A	A	63990385	2	1	90	1	0	0	0	0	0	0	0	1	8759	1195	42	3		3	LGSN	6	63990385	Silent	SNP	G	TCGA-06-5413-01A-01D-1696-08	27804657	63990385	107124682	31	6037											
PPIL6	285755	broad.mit.edu	37	chr6	109752404	109752404	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaaaatcctcagtgagtgCgtcataaagtgcagagggtt	13	6	2	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr6:109752404C>T	uc003ptg.3	-	3	430	c.376G>A	c.(376-378)GCA>ACA	p.A126T	PPIL6_uc010kdo.2_Missense_Mutation_p.A94T|PPIL6_uc010kdp.2_Missense_Mutation_p.A126T	NM_173672	NP_775943	Q8IXY8	PPIL6_HUMAN	peptidylprolyl isomerase-like 6 isoform 1	126					protein folding		peptidyl-prolyl cis-trans isomerase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.00684)|BRCA - Breast invasive adenocarcinoma(108;0.00889)|all cancers(137;0.0106)|OV - Ovarian serous cystadenocarcinoma(136;0.0259)		TCAGTGAGTGCGTCATAAAGT	0.393													T	109752404	T	T	109752404	3	4	90	1	0	0	0	0	1	0	0	0	12331	768	27	1	665	1	PPIL6	6	109752404	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	45762019	109752404	61362663	32	6038											
UNC93A	54346	broad.mit.edu	37	chr6	167704889	167704889	+	Translation_Start_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagaatgggacttcttggtaCtgattgtttttcccatgcct	10	8	1	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr6:167704889C>A	uc003qvq.2	+	1	87	c.-88C>A	c.(-90--86)TACTG>TAATG		UNC93A_uc003qvr.2_Translation_Start_Site	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1							integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CTTCTTGGTACTGATTGTTTT	0.398													A	167704889	A	A	167704889	1	1	90	1	0	0	0	0	0	0	0	0	16993	580	20	5		5	UNC93A	6	167704889	Translation_Start_Site	SNP	C	TCGA-06-5413-01A-01D-1696-08	57952485	167704889	3410178	33	6039											
DAGLB	221955	broad.mit.edu	37	chr7	6476110	6476110	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctggaaaaaacagcgccaggCggatgtaaagcagcttagac	12	9	0	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr7:6476110C>A	uc003sqa.2	-	3	472	c.302G>T	c.(301-303)CGC>CTC	p.R101L	DAGLB_uc011jwt.1_5'Flank|DAGLB_uc011jwu.1_Missense_Mutation_p.R101L|DAGLB_uc003sqb.2_Intron|DAGLB_uc003sqc.2_Intron|DAGLB_uc011jwv.1_Intron|DAGLB_uc003sqd.3_Missense_Mutation_p.R60L|DAGLB_uc011jww.1_Intron	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	101	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CAGCGCCAGGCGGATGTAAAG	0.522													A	6476110	A	A	6476110	3	1	90	1	0	0	0	0	1	0	0	0	4227	768	27	5	1768	5	DAGLB	7	6476110	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08		6476110	152662553	34	6040											
FAM188B	84182	broad.mit.edu	37	chr7	30915152	30915152	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggaaagctgtgtccaacGttttcaacgatgtggttgag	13	7	1	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr7:30915152G>A	uc003tbt.2	+	15	1929	c.1852G>A	c.(1852-1854)GTT>ATT	p.V618I	FAM188B_uc010kwe.2_Missense_Mutation_p.V589I|AQP1_uc011kac.1_5'UTR|FAM188B_uc003tbu.2_Missense_Mutation_p.V138I	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	618											0						TGTGTCCAACGTTTTCAACGA	0.448													A	30915152	A	A	30915152	3	1	90	1	0	0	0	0	1	0	0	0	5515	1145	40	1	1910	1	FAM188B	7	30915152	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	24439042	30915152	128223511	35	6041											
EGFR	1956	broad.mit.edu	37	chr7	55259469	55259469	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcgacctggcagccaggaacGtactggtgaaaacaccgcag	13	12	0	1	rs146795390		TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr7:55259469G>C	uc003tqk.2	+	21	2773	c.2527G>C	c.(2527-2529)GTA>CTA	p.V843L	EGFR_uc010kzg.1_Missense_Mutation_p.V798L|EGFR_uc011kco.1_Missense_Mutation_p.V790L|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	843	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V843I(6)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCCAGGAACGTACTGGTGAA	0.537		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			C	55259469	C	C	55259469	3	2	90	1	0	0	0	0	1	0	0	0	4967	1145	40	5	2873	5	EGFR	7	55259469	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	24344317	55259469	103879194	36	6042											
SERPINE1	5054	broad.mit.edu	37	chr7	100771685	100771685	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttgctctaggatgcagatgtCtccagccctcacctgcctag	9	14	3	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr7:100771685C>G	uc003uxt.2	+	2	159	c.11C>G	c.(10-12)TCT>TGT	p.S4C	SERPINE1_uc011kkj.1_Missense_Mutation_p.S4C	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	4					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	ATGCAGATGTCTCCAGCCCTC	0.622													G	100771685	G	G	100771685	3	3	90	1	0	0	0	0	1	0	0	0	14111	913	32	5	13	5	SERPINE1	7	100771685	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	45512216	100771685	58366978	37	6043											
OR2A1	346528	broad.mit.edu	37	chr7	144015519	144015519	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggctgcatgacgcagacctTtctctgtttgagttttggac	11	9	1	3			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr7:144015519T>G	uc011kud.1	+	1	284	c.284T>G	c.(283-285)TTT>TGT	p.F95C	OR2A9P_uc003wec.1_Intron	NM_001001802	NP_001001802	Q8NGT9	OR2A1_HUMAN	olfactory receptor, family 2, subfamily A,	101	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.14)					ACGCAGACCTTTCTCTGTTTG	0.572													G	144015519	G	G	144015519	3	3	90	1	0	0	0	0	1	0	0	0	10974	1841	64	5	304	5	OR2A1	7	144015519	Missense_Mutation	SNP	T	TCGA-06-5413-01A-01D-1696-08	43243834	144015519	15123144	38	6044											
SSPO	23145	broad.mit.edu	37	chr7	149493793	149493793	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggactgcgaggatggctcGgatgaggagggctgtgtgtt	19	6	0	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr7:149493793G>A	uc010lpk.2	+	46	6789	c.6789G>A	c.(6787-6789)TCG>TCA	p.S2263S		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2263	LDL-receptor class A 8.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGGATGGCTCGGATGAGGAGG	0.652													A	149493793	A	A	149493793	2	1	90	1	0	0	0	0	0	0	0	1	15188	1103	39	2		2	SSPO	7	149493793	Silent	SNP	G	TCGA-06-5413-01A-01D-1696-08	5478274	149493793	9644870	39	6045											
UBE3C	9690	broad.mit.edu	37	chr7	157046788	157046788	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttccgccagggccttgccaaTgtcgtcagcctcgagtggct	12	14	1	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr7:157046788T>C	uc010lqs.2	+	20	3147	c.2835T>C	c.(2833-2835)AAT>AAC	p.N945N	UBE3C_uc003wni.3_Silent_p.N308N	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	945	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		GCCTTGCCAATGTCGTCAGCC	0.562													C	157046788	C	C	157046788	2	2	90	1	0	0	0	0	0	0	0	1	16878	1461	51	4		4	UBE3C	7	157046788	Silent	SNP	T	TCGA-06-5413-01A-01D-1696-08	7552995	157046788	2091875	40	6046											
GCNT1	2650	broad.mit.edu	37	chr9	79118132	79118132	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tcaaaatgcttcctccactcGaaacacctctcttttctggc	4	15	3	0	rs656106		TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr9:79118132G>T	uc010mpf.2	+	3	1176	c.835G>T	c.(835-837)GAA>TAA	p.E279*	GCNT1_uc010mpg.2_Nonsense_Mutation_p.E279*|GCNT1_uc010mph.2_Nonsense_Mutation_p.E279*|GCNT1_uc004akf.3_Nonsense_Mutation_p.E279*|GCNT1_uc010mpi.2_Nonsense_Mutation_p.E279*|GCNT1_uc004akh.3_Nonsense_Mutation_p.E279*	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	279	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						TCCTCCACTCGAAACACCTCT	0.463													T	79118132	T	T	79118132	4	4	90	1	0	0	0	0	0	1	0	0	6300	1059	37	5	837	5	GCNT1	9	79118132	Nonsense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08		79118132	62095299	41	6047											
MRC1	4360	broad.mit.edu	37	chr10	17949554	17949554	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttatctgatgaccagggacGtggctgtggataaataacag	12	6	1	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr10:17949554G>A	uc001ipk.2	+	28	4021	c.3918G>A	c.(3916-3918)ACG>ACA	p.T1306T		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	1306	Extracellular (Potential).|C-type lectin 8.				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						GACCAGGGACGTGGCTGTGGA	0.383													A	17949554	A	A	17949554	2	1	90	1	0	0	0	0	0	0	0	1	9756	1132	40	1		1	MRC1	10	17949554	Silent	SNP	G	TCGA-06-5413-01A-01D-1696-08		17949554	117585193	42	6048											
CTNNA3	29119	broad.mit.edu	37	chr10	69407205	69407205	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctccagtagcttctccaCggtgaatgtttggacctgca	11	11	1	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr10:69407205C>T	uc009xpn.1	-	2	190	c.67G>A	c.(67-69)GTG>ATG	p.V23M	CTNNA3_uc001jmw.2_Missense_Mutation_p.V23M|CTNNA3_uc001jmx.3_Missense_Mutation_p.V23M|CTNNA3_uc009xpo.1_Translation_Start_Site|CTNNA3_uc001jna.2_Missense_Mutation_p.V35M	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	23					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						AGCTTCTCCACGGTGAATGTT	0.393													T	69407205	T	T	69407205	3	4	90	1	0	0	0	0	1	0	0	0	4014	536	19	1	2688	1	CTNNA3	10	69407205	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	51457651	69407205	66127542	43	6049											
TTC17	55761	broad.mit.edu	37	chr11	43411222	43411222	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaacaattagttgctcaaaaAattcacatagaagagaatga	6	5	2	3			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr11:43411222A>C	uc001mxi.2	+	3	284	c.270A>C	c.(268-270)AAA>AAC	p.K90N	TTC17_uc001mxh.2_Missense_Mutation_p.K90N|TTC17_uc010rfj.1_Missense_Mutation_p.K33N	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	90							binding			ovary(5)	5						TTGCTCAAAAAATTCACATAG	0.393													C	43411222	C	C	43411222	3	2	90	1	0	0	0	0	1	0	0	0	16681	11	1	5	280	5	TTC17	11	43411222	Missense_Mutation	SNP	A	TCGA-06-5413-01A-01D-1696-08		43411222	91595294	44	6050											
OR4D9	390199	broad.mit.edu	37	chr11	59282555	59282555	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgaatctcaccttcataCgcccatgtacttcctgctcc	5	16	2	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr11:59282555C>T	uc010rkv.1	+	1	170	c.170C>T	c.(169-171)ACG>ATG	p.T57M		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	57	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACCTTCATACGCCCATGTAC	0.433													T	59282555	T	T	59282555	3	4	90	1	0	0	0	0	1	0	0	0	11059	536	19	1	172	1	OR4D9	11	59282555	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	15871333	59282555	75723961	45	6051											
GLB1L3	112937	broad.mit.edu	37	chr11	134182345	134182345	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgagaagtccatctgctccGgaggccgcctccgtgcccac	11	16	1	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr11:134182345G>A	uc009zdf.2	+	14	1750	c.1390G>A	c.(1390-1392)GGA>AGA	p.G464R	GLB1L3_uc001qho.3_RNA	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	464					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CATCTGCTCCGGAGGCCGCCT	0.607													A	134182345	A	A	134182345	3	1	90	1	0	0	0	0	1	0	0	0	6430	1117	39	2	1444	2	GLB1L3	11	134182345	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	74899790	134182345	824171	46	6052											
KLRD1	3824	broad.mit.edu	37	chr12	10466085	10466085	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcacaccgcctggttgtgggAgaatggctctgcactctccc	12	14	2	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr12:10466085A>T	uc001qxw.3	+	6	589	c.392A>T	c.(391-393)GAG>GTG	p.E131V	KLRD1_uc001qxx.3_Missense_Mutation_p.E131V|KLRD1_uc001qxy.3_Missense_Mutation_p.E100V|KLRD1_uc009zhh.2_Missense_Mutation_p.E110V|KLRD1_uc009zhi.2_3'UTR|KLRD1_uc001qxz.3_Missense_Mutation_p.E132V	NM_001114396	NP_001107868	Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D,	131	Extracellular (Potential).|C-type lectin.				cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0						TGGTTGTGGGAGAATGGCTCT	0.418													T	10466085	T	T	10466085	3	4	90	1	0	0	0	0	1	0	0	0	8419	304	11	5	410	5	KLRD1	12	10466085	Missense_Mutation	SNP	A	TCGA-06-5413-01A-01D-1696-08		10466085	123385810	47	6053											
TEP1	7011	broad.mit.edu	37	chr14	20848171	20848171	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcccattggtggagaaggccAcagcagtaggggatgaggaa	17	7	0	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr14:20848171A>G	uc001vxe.2	-	35	5085	c.5045T>C	c.(5044-5046)GTG>GCG	p.V1682A	TEP1_uc010ahk.2_Missense_Mutation_p.V1025A|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.V1574A|TEP1_uc010tlh.1_Missense_Mutation_p.V20A	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1682	WD 2.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGAGAAGGCCACAGCAGTAGG	0.507													G	20848171	G	G	20848171	3	3	90	1	0	0	0	0	1	0	0	0	15756	159	6	4	2922	4	TEP1	14	20848171	Missense_Mutation	SNP	A	TCGA-06-5413-01A-01D-1696-08		20848171	86501369	48	6054											
CHD8	57680	broad.mit.edu	37	chr14	21860822	21860832	+	Frame_Shift_Del	DEL	AGGAGTCAATG	-	-													ggagagtcaccatattctccAggagtcaatgagggactgtc							TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr14:21860822_21860832delAGGAGTCAATG	uc001was.1	-	34	5862_5872	c.5768_5778delCATTGACTCCT	c.(5767-5778)TCATTGACTCCTfs	p.S1923fs	CHD8_uc001war.1_Frame_Shift_Del_p.S1819fs|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2202_2205					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CATATTCTCCAGGAGTCAATGAGGGACTGTC	0.555													-	21860832	-	-	21860822	7	5	90	1	0	1	0	1	0	0	0	0	3331	175	7	0	1150	0	CHD8	14	21860822	Frame_Shift_Del	DEL	AGGAGTCAATG	TCGA-06-5413-01A-01D-1696-08	1012651	21860822	85488718	49	6055											
TMEM229B	161145	broad.mit.edu	37	chr14	67940502	67940502	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagatgaagagggcccacaCgctcgtgaccccagggaact	13	12	0	4			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr14:67940502C>T	uc001xjk.2	-	3	549	c.139G>A	c.(139-141)GTG>ATG	p.V47M	TMEM229B_uc001xjj.1_RNA	NM_182526	NP_872332	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	47	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						AGGGCCCACACGCTCGTGACC	0.617													T	67940502	T	T	67940502	3	4	90	1	0	0	0	0	1	0	0	0	16145	536	19	1	368	1	TMEM229B	14	67940502	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	46079680	67940502	39409038	50	6056											
PTX4	390667	broad.mit.edu	37	chr16	1537571	1537571	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggcccgagggctgcagtgCcagggtgggccacgggcagc	19	14	0	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr16:1537571C>T	uc010uvf.1	-	2	527	c.527G>A	c.(526-528)GGC>GAC	p.G176D		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	181						extracellular region	metal ion binding				0						GGCTGCAGTGCCAGGGTGGGC	0.726													T	1537571	T	T	1537571	3	4	90	1	0	0	0	0	1	0	0	0	12823	739	26	3	901	3	PTX4	16	1537571	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08		1537571	88817182	51	6057											
PRKCB	5579	broad.mit.edu	37	chr16	24104126	24104126	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tttcagtaagagatgctaaaAaccttgtacctatggacccc	7	10	1	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr16:24104126A>T	uc002dmd.2	+	6	741	c.544A>T	c.(544-546)AAC>TAC	p.N182Y	PRKCB_uc002dme.2_Missense_Mutation_p.N182Y	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	182	C2.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	AGATGCTAAAAACCTTGTACC	0.418													T	24104126	T	T	24104126	3	4	90	1	0	0	0	0	1	0	0	0	12508	14	1	5	566	5	PRKCB	16	24104126	Missense_Mutation	SNP	A	TCGA-06-5413-01A-01D-1696-08	22566555	24104126	66250627	52	6058											
SPNS1	83985	broad.mit.edu	37	chr16	28992797	28992797	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctctgtctcccaggtgacaCcgggtctaggagtggtggcc	14	13	3	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr16:28992797C>A	uc010vdi.1	+	7	810	c.670C>A	c.(670-672)CCG>ACG	p.P224T	uc010vct.1_Intron|SPNS1_uc002drx.2_Missense_Mutation_p.P151T|SPNS1_uc002dsa.2_Missense_Mutation_p.P224T|SPNS1_uc002drz.2_Missense_Mutation_p.P224T|SPNS1_uc010byp.2_Missense_Mutation_p.P202T|SPNS1_uc010byq.1_Missense_Mutation_p.P156T	NM_001142448	NP_001135920	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 isoform 1	224	Helical; (Potential).				lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding				0						CCAGGTGACACCGGGTCTAGG	0.622											OREG0023712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	28992797	A	A	28992797	3	1	90	1	0	0	0	0	1	0	0	0	15073	507	18	5	692	5	SPNS1	16	28992797	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	4888671	28992797	61361956	53	6059											
SETD1A	9739	broad.mit.edu	37	chr16	30970183	30970183	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaaggtgtaccgctatgatgGagtccacttcagtgtcaacg	12	9	2	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr16:30970183G>A	uc002ead.1	+	2	817	c.131G>A	c.(130-132)GGA>GAA	p.G44E	SETD1A_uc002eae.1_Missense_Mutation_p.G44E	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	44					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CGCTATGATGGAGTCCACTTC	0.597													A	30970183	A	A	30970183	3	1	90	1	0	0	0	0	1	0	0	0	14130	1174	41	3	133	3	SETD1A	16	30970183	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	1977386	30970183	59384570	54	6060											
ZPBP2	124626	broad.mit.edu	37	chr17	38027064	38027064	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gattgggcctaatgaaaagaCgttaacaggtaaatttgatt	10	4	0	3			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr17:38027064C>T	uc002hte.2	+	3	389	c.236C>T	c.(235-237)ACG>ATG	p.T79M	ZPBP2_uc002htf.2_Missense_Mutation_p.T57M	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	79					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			AATGAAAAGACGTTAACAGGT	0.284													T	38027064	T	T	38027064	3	4	90	1	0	0	0	0	1	0	0	0	18217	536	19	1	246	1	ZPBP2	17	38027064	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08		38027064	43168146	55	6061											
AKAP1	8165	broad.mit.edu	37	chr17	55189944	55189944	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tctacgctcccccattgcctTcactggcactgccttctctg	6	18	3	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr17:55189944T>A	uc002iux.2	+	5	2299	c.2068T>A	c.(2068-2070)TCA>ACA	p.S690T	AKAP1_uc010wnl.1_Missense_Mutation_p.S690T|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Missense_Mutation_p.S690T	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	690					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					CCCATTGCCTTCACTGGCACT	0.502													A	55189944	A	A	55189944	3	1	90	1	0	0	0	0	1	0	0	0	445	1783	62	5	2082	5	AKAP1	17	55189944	Missense_Mutation	SNP	T	TCGA-06-5413-01A-01D-1696-08	17162880	55189944	26005266	56	6062											
MPO	4353	broad.mit.edu	37	chr17	56352985	56352985	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggttcaggctcttgagctctGtggccagccggttgtgctcc	14	12	3	1			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr17:56352985G>C	uc002ivu.1	-	8	1460	c.1283C>G	c.(1282-1284)ACA>AGA	p.T428R		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	428					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CTTGAGCTCTGTGGCCAGCCG	0.617													C	56352985	C	C	56352985	3	2	90	1	0	0	0	0	1	0	0	0	9732	1377	48	5	974	5	MPO	17	56352985	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08	1163041	56352985	24842225	57	6063											
LRP3	4037	broad.mit.edu	37	chr19	33696170	33696170	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	agggaagctgggccaggcatCctgccaggcagatgagttcc	15	11	0	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr19:33696170C>G	uc010edh.2	+	5	587	c.494C>G	c.(493-495)TCC>TGC	p.S165C	LRP3_uc010xrp.1_Missense_Mutation_p.S39C|LRP3_uc002nuk.3_Missense_Mutation_p.S39C	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	165	Extracellular (Potential).|LDL-receptor class A 1.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)					GGCCAGGCATCCTGCCAGGCA	0.662													G	33696170	G	G	33696170	3	3	90	1	0	0	0	0	1	0	0	0	8958	855	30	5	512	5	LRP3	19	33696170	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08		33696170	25432813	58	6064											
ZNF540	163255	broad.mit.edu	37	chr19	38103381	38103381	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcgtggacagcttaatcgGcataaaacaatccatactgg	10	9	0	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr19:38103381G>A	uc002ogq.2	+	5	1532	c.1200G>A	c.(1198-1200)CGG>CGA	p.R400R	ZNF540_uc002ogu.2_Silent_p.R400R|ZNF540_uc010efq.2_Silent_p.R368R	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	400	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGCTTAATCGGCATAAAACAA	0.373													A	38103381	A	A	38103381	2	1	90	1	0	0	0	0	0	0	0	1	17972	1190	42	3		3	ZNF540	19	38103381	Silent	SNP	G	TCGA-06-5413-01A-01D-1696-08	4407211	38103381	21025602	59	6065											
NCR1	9437	broad.mit.edu	37	chr19	55420766	55420766	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggatacgggaaggtccaggCggagttccccctgggccctg	16	13	0	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr19:55420766C>T	uc002qib.2	+	4	556	c.518C>T	c.(517-519)GCG>GTG	p.A173V	NCR1_uc002qic.2_Missense_Mutation_p.A173V|NCR1_uc002qie.2_Missense_Mutation_p.A173V|NCR1_uc002qid.2_Missense_Mutation_p.A78V|NCR1_uc002qif.2_Missense_Mutation_p.A78V|NCR1_uc010esj.2_Missense_Mutation_p.A66V	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	173	Extracellular (Potential).|Ig-like 2.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		AAGGTCCAGGCGGAGTTCCCC	0.572													T	55420766	T	T	55420766	3	4	90	1	0	0	0	0	1	0	0	0	10237	768	27	1	532	1	NCR1	19	55420766	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08	17317385	55420766	3708217	60	6066											
HM13	81502	broad.mit.edu	37	chr20	30136902	30136902	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agcagcatcgttggcgtctgGtacctgctgaggaaggtgag	16	8	1	2			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr20:30136902G>T	uc002wwe.2	+	5	639	c.525G>T	c.(523-525)TGG>TGT	p.W175C	HM13_uc002wwc.2_Missense_Mutation_p.W175C|HM13_uc002wwd.2_Missense_Mutation_p.W175C|HM13_uc002wwf.2_Missense_Mutation_p.W51C|HM13_uc010gdu.2_Missense_Mutation_p.W51C	NM_030789	NP_110416	Q8TCT9	HM13_HUMAN	minor histocompatibility antigen 13 isoform 1	175	Cytoplasmic (Potential).				membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)	1	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			TTGGCGTCTGGTACCTGCTGA	0.577													T	30136902	T	T	30136902	3	4	90	1	0	0	0	0	1	0	0	0	7217	1270	44	5	610	5	HM13	20	30136902	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08		30136902	32888618	61	6067											
HUNK	30811	broad.mit.edu	37	chr21	33296873	33296873	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcagatccagcagatgatcCgccaccccaatatcactcag	7	15	3	3			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr21:33296873C>T	uc002yph.2	+	2	715	c.355C>T	c.(355-357)CGC>TGC	p.R119C		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	119	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						GCAGATGATCCGCCACCCCAA	0.488													T	33296873	T	T	33296873	3	4	90	1	0	0	0	0	1	0	0	0	7458	652	23	2	361	2	HUNK	21	33296873	Missense_Mutation	SNP	C	TCGA-06-5413-01A-01D-1696-08		33296873	14833022	62	6068											
LZTR1	8216	broad.mit.edu	37	chr22	21344765	21344765	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtattctctgggcaaagcGgagccaaaataaccaacaac	8	10	1	0			TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr22:21344765G>A	uc002zto.2	+	8	845	c.742G>A	c.(742-744)GGA>AGA	p.G248R	LZTR1_uc002ztn.2_Missense_Mutation_p.G207R|LZTR1_uc011ahy.1_Missense_Mutation_p.G229R|LZTR1_uc010gsr.1_Missense_Mutation_p.G119R	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	248	Kelch 4.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGGGCAAAGCGGAGCCAAAAT	0.562													A	21344765	A	A	21344765	3	1	90	1	0	0	0	0	1	0	0	0	9137	1117	39	2	772	2	LZTR1	22	21344765	Missense_Mutation	SNP	G	TCGA-06-5413-01A-01D-1696-08		21344765	29959801	63	6069											
DEPDC5	9681	broad.mit.edu	37	chr22	32198714	32198715	+	Frame_Shift_Ins	INS	-	C	C													gataagcactacatcaaccgINScaactttgaccgaactgggc							TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr22:32198714_32198715insC	uc003als.2	+	15	1113_1114	c.971_972insC	c.(970-972)CGCfs	p.R324fs	DEPDC5_uc011als.1_Frame_Shift_Ins_p.R324fs|DEPDC5_uc011alu.1_Frame_Shift_Ins_p.R324fs|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Frame_Shift_Ins_p.R324fs|DEPDC5_uc003alr.1_Frame_Shift_Ins_p.R324fs|DEPDC5_uc011alt.1_Frame_Shift_Ins_p.R296fs	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	324					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						TACATCAACCGCAACTTTGACC	0.446													C	32198715	C	C	32198714	7	5	90	1	0	1	1	0	0	0	0	0	4442	1087	38	0	1025	0	DEPDC5	22	32198714	Frame_Shift_Ins	INS	-	TCGA-06-5413-01A-01D-1696-08	10853949	32198714	19105852	64	6070											
SBF1	6305	broad.mit.edu	37	chr22	50895482	50895483	+	In_Frame_Ins	INS	-	GAGGCC	GAGGCC													ctcggggtgcggtccgtctgINSgaggccgaggccgccatggg							TCGA-06-5413-01A-01D-1696-08	TCGA-06-5413-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	72c13e51-0dd2-4e96-af37-aa471407436f	2c0bbd3a-7384-4957-9516-5d34f8280208	g.chr22:50895482_50895483insGAGGCC	uc003blh.2	-	29	4079_4080	c.3884_3885insGGCCTC	c.(3883-3885)TCC>TCGGCCTCC	p.1295_1295S>SAS	SBF1_uc003ble.2_5'Flank|SBF1_uc003blf.2_5'Flank|SBF1_uc011arx.1_Intron	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGGTCCGTCTGGAGGCCGAGGC	0.678													GAGGCC	50895483	GAGGCC	GAGGCC	50895482	7	5	90	1	0	1	1	0	0	0	0	0	13858	1335	47	0	1848	0	SBF1	22	50895482	In_Frame_Ins	INS	-	TCGA-06-5413-01A-01D-1696-08	18696768	50895482	409084	65	6071											
CYP4B1	1580	broad.mit.edu	37	chr1	47278284	47278284	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgtgttcactgagtctacaCgtatcatgctggtgagctcc	10	12	3	2			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr1:47278284C>T	uc001cqm.3	+	4	568	c.484C>T	c.(484-486)CGT>TGT	p.R162C	CYP4B1_uc009vyl.1_Translation_Start_Site|CYP4B1_uc001cqn.3_Missense_Mutation_p.R162C|CYP4B1_uc009vym.2_Missense_Mutation_p.R147C|CYP4B1_uc010omk.1_Translation_Start_Site|CYP4B1_uc010oml.1_Translation_Start_Site	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	162					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TGAGTCTACACGTATCATGCT	0.567													T	47278284	T	T	47278284	3	4	91	1	0	0	0	0	1	0	0	0	4185	536	19	1	498	1	CYP4B1	1	47278284	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08		47278284	201972337	1	6072											
HRNR	388697	broad.mit.edu	37	chr1	152187706	152187706	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatctagagccgtgttgtccGtagccagaggagtgacctga	14	9	1	4			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr1:152187706G>A	uc001ezt.1	-	3	6475	c.6399C>T	c.(6397-6399)TAC>TAT	p.Y2133Y		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2133					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTGTTGTCCGTAGCCAGAGG	0.567													A	152187706	A	A	152187706	2	1	91	1	0	0	0	0	0	0	0	1	7359	1140	40	1		1	HRNR	1	152187706	Silent	SNP	G	TCGA-06-5414-01A-01D-1486-08	104909422	152187706	97062915	2	6073											
S100A8	6279	broad.mit.edu	37	chr1	153362715	153362715	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaaccagacgtctgcacccTttttctgtcaagattgagga	9	10	3	4			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr1:153362715T>C	uc001fbs.2	-	3	201	c.146A>G	c.(145-147)AAG>AGG	p.K49R		NM_002964	NP_002955	P05109	S10A8_HUMAN	S100 calcium-binding protein A8	49	EF-hand 2.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCTGCACCCTTTTTCTGTCA	0.507													C	153362715	C	C	153362715	3	2	91	1	0	0	0	0	1	0	0	0	13786	1609	56	4	139	4	S100A8	1	153362715	Missense_Mutation	SNP	T	TCGA-06-5414-01A-01D-1486-08	1175009	153362715	95887906	3	6074											
CYTIP	9595	broad.mit.edu	37	chr2	158300464	158300464	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgtggagtaagagctataCgctggcccagcgcagaagtc	14	9	0	2			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr2:158300464C>T	uc002tzj.1	-	1	141	c.69G>A	c.(67-69)GCG>GCA	p.A23A	CYTIP_uc010zcl.1_Intron	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	23					regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						AAGAGCTATACGCTGGCCCAG	0.512													T	158300464	T	T	158300464	2	4	91	1	0	0	0	0	0	0	0	1	4207	523	19	1		1	CYTIP	2	158300464	Silent	SNP	C	TCGA-06-5414-01A-01D-1486-08		158300464	84898909	4	6075											
SGOL2	151246	broad.mit.edu	37	chr2	201434569	201434569	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatcaaaatgtatatggtttAgatgattcagaacatatttc	6	4	2	3			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr2:201434569A>G	uc002uvw.2	+	6	770	c.657A>G	c.(655-657)TTA>TTG	p.L219L	SGOL2_uc002uvv.3_Silent_p.L219L|SGOL2_uc010zhd.1_Silent_p.L219L|SGOL2_uc010zhe.1_Silent_p.L219L	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	219					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						TATATGGTTTAGATGATTCAG	0.303													G	201434569	G	G	201434569	2	3	91	1	0	0	0	0	0	0	0	1	14217	417	15	4		4	SGOL2	2	201434569	Silent	SNP	A	TCGA-06-5414-01A-01D-1486-08	43134105	201434569	41764804	5	6076											
COL4A3	1285	broad.mit.edu	37	chr2	228118844	228118844	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcaggacctcaagggggaaaAgggagacaagggagcaatgg	18	6	1	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr2:228118844A>G	uc002vom.1	+	14	944	c.782A>G	c.(781-783)AAG>AGG	p.K261R	COL4A3_uc002von.1_Missense_Mutation_p.K261R|COL4A3_uc002voo.1_Missense_Mutation_p.K261R|COL4A3_uc002vop.1_Missense_Mutation_p.K261R|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	261	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AAGGGGGAAAAGGGAGACAAG	0.433													G	228118844	G	G	228118844	3	3	91	1	0	0	0	0	1	0	0	0	3691	72	3	4	836	4	COL4A3	2	228118844	Missense_Mutation	SNP	A	TCGA-06-5414-01A-01D-1486-08	26684275	228118844	15080529	6	6077											
SPHKAP	80309	broad.mit.edu	37	chr2	228884217	228884217	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccatctggactctgaacaacGacgattttggggagctcatt	10	10	3	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr2:228884217G>A	uc002vpq.2	-	7	1400	c.1353C>T	c.(1351-1353)GTC>GTT	p.V451V	SPHKAP_uc002vpp.2_Silent_p.V451V|SPHKAP_uc010zlx.1_Silent_p.V451V	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	451						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCTGAACAACGACGATTTTGG	0.507													A	228884217	A	A	228884217	2	1	91	1	0	0	0	0	0	0	0	1	15047	1045	37	2		2	SPHKAP	2	228884217	Silent	SNP	G	TCGA-06-5414-01A-01D-1486-08	765373	228884217	14315156	7	6078											
DPPA4	55211	broad.mit.edu	37	chr3	109050752	109050752	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagcttcaattgttggcacCaggcccgcagaatgtcccgg	11	13	2	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr3:109050752C>T	uc003dxq.3	-	3	360	c.305G>A	c.(304-306)TGG>TAG	p.W102*	DPPA4_uc011bho.1_Nonsense_Mutation_p.W102*|DPPA4_uc011bhp.1_Nonsense_Mutation_p.W102*	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	102						nucleus	protein binding			upper_aerodigestive_tract(1)	1						TTGTTGGCACCAGGCCCGCAG	0.532													T	109050752	T	T	109050752	4	4	91	1	0	0	0	0	0	1	0	0	4736	595	21	3	629	3	DPPA4	3	109050752	Nonsense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08		109050752	88971678	8	6079											
FNDC3B	64778	broad.mit.edu	37	chr3	172096080	172096080	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtttatttcaatctacagagGacccagccacacctacaagg	7	12	2	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr3:172096080G>A	uc003fhy.2	+	24	3201	c.3029G>A	c.(3028-3030)GGA>GAA	p.G1010E	FNDC3B_uc003fhz.3_Missense_Mutation_p.G1010E	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	1010	Fibronectin type-III 8.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ATCTACAGAGGACCCAGCCAC	0.448													A	172096080	A	A	172096080	3	1	91	1	0	0	0	0	1	0	0	0	5970	1174	41	3	3119	3	FNDC3B	3	172096080	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08	63045328	172096080	25926350	9	6080											
CPZ	8532	broad.mit.edu	37	chr4	8621243	8621243	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacggagcccgacccgctcCgggcgcgcaggcagccctcg	14	20	0	0	rs143690050		TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr4:8621243C>T	uc003glm.2	+	11	1984	c.1858C>T	c.(1858-1860)CGG>TGG	p.R620W	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.R483W|CPZ_uc003glo.2_Missense_Mutation_p.R609W|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	620					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						CGACCCGCTCCGGGCGCGCAG	0.667													T	8621243	T	T	8621243	3	4	91	1	0	0	0	0	1	0	0	0	3839	643	23	2	1900	2	CPZ	4	8621243	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08		8621243	182533033	10	6081											
ADH1C	126	broad.mit.edu	37	chr4	100268910	100268910	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaagtatttcaccttaatgcGaacttcatgagccttaggag	8	8	2	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr4:100268910G>A	uc003huu.2	-	2	197	c.112C>T	c.(112-114)CGC>TGC	p.R38C		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	38					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	ACCTTAATGCGAACTTCATGA	0.338									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				A	100268910	A	A	100268910	3	1	91	1	0	0	0	0	1	0	0	0	309	1058	37	2	1047	2	ADH1C	4	100268910	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08	91647667	100268910	90885366	11	6082											
LRBA	987	broad.mit.edu	37	chr4	151791721	151791725	+	Frame_Shift_Del	DEL	TTATG	-	-													aatcaggatctggatgctgtTtatgtatcacctgagtacca							TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr4:151791721_151791725delTTATG	uc010ipj.2	-	20	2875_2879	c.2401_2405delCATAA	c.(2401-2406)CATAAAfs	p.H801fs	LRBA_uc003ilu.3_Frame_Shift_Del_p.H801fs	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	801_802						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TGGATGCTGTTTATGTATCACCTGA	0.312													-	151791725	-	-	151791721	7	5	91	1	0	1	0	1	0	0	0	0	8931	1841	64	0	6342	0	LRBA	4	151791721	Frame_Shift_Del	DEL	TTATG	TCGA-06-5414-01A-01D-1486-08	51522811	151791721	39362555	12	6083											
DCHS2	54798	broad.mit.edu	37	chr4	155249289	155249289	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcattatttccttcatcaGgatcctttgcaaacacagtt	5	11	2	0	rs111557030	byFrequency	TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr4:155249289G>A	uc003inw.2	-	12	2609	c.2609C>T	c.(2608-2610)CCT>CTT	p.P870L	DCHS2_uc003inx.2_Missense_Mutation_p.P1325L	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	870	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCCTTCATCAGGATCCTTTGC	0.348													A	155249289	A	A	155249289	3	1	91	1	0	0	0	0	1	0	0	0	4288	1000	35	3	6293	3	DCHS2	4	155249289	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08	3457568	155249289	35904987	13	6084											
ADAMTS16	170690	broad.mit.edu	37	chr5	5146447	5146447	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctggctttattgtgcagaCgttgggaaagacaggcacta	12	8	0	2			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr5:5146447C>T	uc003jdl.2	+	3	518	c.380C>T	c.(379-381)ACG>ATG	p.T127M	ADAMTS16_uc003jdk.1_Missense_Mutation_p.T127M|ADAMTS16_uc003jdj.1_Missense_Mutation_p.T127M	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	127					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ATTGTGCAGACGTTGGGAAAG	0.522													T	5146447	T	T	5146447	3	4	91	1	0	0	0	0	1	0	0	0	261	536	19	1	390	1	ADAMTS16	5	5146447	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08		5146447	175768813	14	6085											
ADAMTS16	170690	broad.mit.edu	37	chr5	5190212	5190212	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgactggtctggatatatgTtcctggaagaatgagccctg	12	8	1	3			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr5:5190212T>C	uc003jdl.2	+	7	1314	c.1176T>C	c.(1174-1176)TGT>TGC	p.C392C	ADAMTS16_uc003jdk.1_Silent_p.C392C|ADAMTS16_uc003jdj.1_Silent_p.C392C	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	392	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TGGATATATGTTCCTGGAAGA	0.527													C	5190212	C	C	5190212	2	2	91	1	0	0	0	0	0	0	0	1	261	1731	60	4		4	ADAMTS16	5	5190212	Silent	SNP	T	TCGA-06-5414-01A-01D-1486-08	43765	5190212	175725048	15	6086											
RASGRF2	5924	broad.mit.edu	37	chr5	80408515	80408515	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgccccagatccgttatgCcagcgtggagcgcctcttgg	13	13	1	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr5:80408515C>T	uc003kha.1	+	14	1925	c.1925C>T	c.(1924-1926)GCC>GTC	p.A642V	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	642	N-terminal Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		ATCCGTTATGCCAGCGTGGAG	0.483													T	80408515	T	T	80408515	3	4	91	1	0	0	0	0	1	0	0	0	13073	739	26	3	1979	3	RASGRF2	5	80408515	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08	75218303	80408515	100506745	16	6087											
PCDHGB2	56103	broad.mit.edu	37	chr5	140741338	140741338	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcccgcgctcagcgccaacGtgagcctgcgcgtgttagtg	14	15	1	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr5:140741338G>A	uc003ljs.1	+	1	1636	c.1636G>A	c.(1636-1638)GTG>ATG	p.V546M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.V546M|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	546	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCGCCAACGTGAGCCTGCG	0.682													A	140741338	A	A	140741338	3	1	91	1	0	0	0	0	1	0	0	0	11563	1145	40	1	1638	1	PCDHGB2	5	140741338	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08	60332823	140741338	40173922	17	6088											
TIMD4	91937	broad.mit.edu	37	chr5	156346519	156346519	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cttccatgctgcacgtcattGaggacatttttactatctcc	6	12	2	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr5:156346519G>T	uc003lwh.2	-	9	1143	c.1086C>A	c.(1084-1086)CTC>CTA	p.L362L	TIMD4_uc010jii.2_Silent_p.L334L|TIMD4_uc003lwg.2_Silent_p.L64L	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	362	Cytoplasmic (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCACGTCATTGAGGACATTTT	0.438													T	156346519	T	T	156346519	2	4	91	1	0	0	0	0	0	0	0	1	15900	1277	45	5		5	TIMD4	5	156346519	Silent	SNP	G	TCGA-06-5414-01A-01D-1486-08	15605181	156346519	24568741	18	6089											
GABRA6	2559	broad.mit.edu	37	chr5	161116076	161116076	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taaaatctggacgcctgacaCctttttcagaaatggtaaaa	7	8	2	2			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr5:161116076C>A	uc003lyu.2	+	4	685	c.347C>A	c.(346-348)ACC>AAC	p.T116N	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	116	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACGCCTGACACCTTTTTCAGA	0.418										TCGA Ovarian(5;0.080)			A	161116076	A	A	161116076	3	1	91	1	0	0	0	0	1	0	0	0	6165	507	18	5	361	5	GABRA6	5	161116076	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08	4769557	161116076	19799184	19	6090											
TMEM63B	55362	broad.mit.edu	37	chr6	44107303	44107303	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggttgtgggcgtcctctcCgtaggcatcgtgctgcctgt	15	11	1	0	rs145356402		TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr6:44107303C>T	uc003owr.2	+	7	571	c.507C>T	c.(505-507)TCC>TCT	p.S169S	TMEM63B_uc003owq.1_Silent_p.S169S|TMEM63B_uc010jyy.1_Silent_p.S72S|TMEM63B_uc003ows.2_Silent_p.S72S|TMEM63B_uc010jyz.2_5'Flank	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	169	Helical; (Potential).					integral to membrane	nucleotide binding|protein binding	p.S169S(1)		pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			GCGTCCTCTCCGTAGGCATCG	0.627													T	44107303	T	T	44107303	2	4	91	1	0	0	0	0	0	0	0	1	16188	639	23	2		2	TMEM63B	6	44107303	Silent	SNP	C	TCGA-06-5414-01A-01D-1486-08		44107303	127007764	20	6091											
VNN2	8875	broad.mit.edu	37	chr6	133078573	133078573	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgtgggggtcttgacacGgaatccagttcacctgaggg	14	10	2	2	rs149351884		TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr6:133078573G>A	uc003qdt.2	-	2	337	c.326C>T	c.(325-327)CCG>CTG	p.P109L	VNN2_uc003qds.2_5'UTR|VNN2_uc010kgb.2_Missense_Mutation_p.P109L|VNN2_uc003qdv.2_Missense_Mutation_p.P56L	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	109	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		GTCTTGACACGGAATCCAGTT	0.418													A	133078573	A	A	133078573	3	1	91	1	0	0	0	0	1	0	0	0	17180	1116	39	2	1260	2	VNN2	6	133078573	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08	88971270	133078573	38036494	21	6092											
GRM3	2913	broad.mit.edu	37	chr7	86468833	86468833	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagacaaactgcattgcccGcatcttcgatggggtcaaga	10	11	2	2			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr7:86468833G>A	uc003uid.2	+	4	3102	c.2003G>A	c.(2002-2004)CGC>CAC	p.R668H	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.R540H|GRM3_uc010leh.2_Missense_Mutation_p.R260H	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	668	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGCATTGCCCGCATCTTCGAT	0.537													A	86468833	A	A	86468833	3	1	91	1	0	0	0	0	1	0	0	0	6798	1087	38	1	2013	1	GRM3	7	86468833	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08		86468833	72669830	22	6093											
ZKSCAN5	23660	broad.mit.edu	37	chr7	99123821	99123821	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggaagagctacaatcagcgGgtgcacctcacccagcacca	11	14	2	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr7:99123821G>T	uc003uqv.2	+	6	1282	c.1158G>T	c.(1156-1158)CGG>CGT	p.R386R	ZKSCAN5_uc010lfx.2_Silent_p.R386R|ZKSCAN5_uc003uqw.2_Silent_p.R386R|ZKSCAN5_uc003uqx.2_Silent_p.R313R|ZKSCAN5_uc003uqy.2_Silent_p.R122R	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	386	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					ACAATCAGCGGGTGCACCTCA	0.537													T	99123821	T	T	99123821	2	4	91	1	0	0	0	0	0	0	0	1	17687	1219	43	5		5	ZKSCAN5	7	99123821	Silent	SNP	G	TCGA-06-5414-01A-01D-1486-08	12654988	99123821	60014842	23	6094											
KEL	3792	broad.mit.edu	37	chr7	142658590	142658590	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcctctcttctggagtgctcTgtgggaggaaccaagaggtg	15	9	3	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr7:142658590T>C	uc003wcb.2	-	3	292	c.82_splice	c.e3-1	p.S28_splice		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase						proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TGGAGTGCTCTGTGGGAGGAA	0.552													C	142658590	C	C	142658590	5	2	91	1	0	0	0	0	0	0	1	0	8142	1594	55	4	2186	4	KEL	7	142658590	Splice_Site	SNP	T	TCGA-06-5414-01A-01D-1486-08	43534769	142658590	16480073	24	6095											
DLC1	10395	broad.mit.edu	37	chr8	12956045	12956045	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatacagagttgaggcttggCcgatgtgagctctggaaact	14	7	1	3			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr8:12956045C>T	uc003wwm.2	-	10	3474	c.3030G>A	c.(3028-3030)CGG>CGA	p.R1010R	DLC1_uc003wwk.1_Silent_p.R573R|DLC1_uc003wwl.1_Silent_p.R607R|DLC1_uc011kxx.1_Silent_p.R499R	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1010					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TGAGGCTTGGCCGATGTGAGC	0.463													T	12956045	T	T	12956045	2	4	91	1	0	0	0	0	0	0	0	1	4550	726	26	3		3	DLC1	8	12956045	Silent	SNP	C	TCGA-06-5414-01A-01D-1486-08		12956045	133407977	25	6096											
TUSC3	7991	broad.mit.edu	37	chr8	15519787	15519787	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcatctataacaagactggTtgggccatggtgtctctggt	11	8	3	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr8:15519787T>G	uc003wwt.2	+	5	900	c.690T>G	c.(688-690)GGT>GGG	p.G230G	TUSC3_uc003wwr.2_Silent_p.G230G|TUSC3_uc003wws.2_Silent_p.G230G|TUSC3_uc003wwu.2_Silent_p.G230G|TUSC3_uc003wwv.2_Silent_p.G230G|TUSC3_uc003www.2_Silent_p.G230G|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Silent_p.G230G	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	230	Helical; (Potential).				cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		ACAAGACTGGTTGGGCCATGG	0.368													G	15519787	G	G	15519787	2	3	91	1	0	0	0	0	0	0	0	1	16775	1712	60	5		5	TUSC3	8	15519787	Silent	SNP	T	TCGA-06-5414-01A-01D-1486-08	2563742	15519787	130844235	26	6097											
SFTPC	6440	broad.mit.edu	37	chr8	22020183	22020183	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtggtggtggtcctcatcGtcgtggtgattgtgggagcc	18	7	1	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr8:22020183G>A	uc003xax.3	+	2	297	c.139G>A	c.(139-141)GTC>ATC	p.V47I	SFTPC_uc003xaw.3_Missense_Mutation_p.V96I|SFTPC_uc011kza.1_Missense_Mutation_p.V47I|SFTPC_uc003xaz.2_Missense_Mutation_p.V47I|SFTPC_uc003xay.3_Missense_Mutation_p.V47I|BMP1_uc011kzb.1_5'Flank|BMP1_uc003xba.2_5'Flank|BMP1_uc003xbb.2_5'Flank|BMP1_uc003xbe.2_5'Flank|BMP1_uc003xbc.2_5'Flank|BMP1_uc003xbd.2_5'Flank|BMP1_uc003xbf.2_5'Flank|BMP1_uc003xbg.2_5'Flank|BMP1_uc011kzc.1_5'Flank|BMP1_uc003xbh.2_5'Flank|BMP1_uc003xbi.2_5'Flank	NM_003018	NP_003009	P11686	PSPC_HUMAN	surfactant protein C precursor	47					respiratory gaseous exchange	extracellular space					0				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGTCCTCATCGTCGTGGTGAT	0.597													A	22020183	A	A	22020183	3	1	91	1	0	0	0	0	1	0	0	0	14192	1145	40	1	145	1	SFTPC	8	22020183	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08	6500396	22020183	124343839	27	6098											
PHYHIP	9796	broad.mit.edu	37	chr8	22079267	22079267	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ccagcggccgtagggggagtCctgcgggggctggcccgtgt	20	12	0	0			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr8:22079267C>G	uc003xbk.3	-	6	1286	c.592G>C	c.(592-594)GAC>CAC	p.D198H	PHYHIP_uc003xbj.3_Missense_Mutation_p.D198H	NM_001099335	NP_001092805	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	198											0				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		TAGGGGGAGTCCTGCGGGGGC	0.627													G	22079267	G	G	22079267	3	3	91	1	0	0	0	0	1	0	0	0	11866	855	30	5	404	5	PHYHIP	8	22079267	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08	59084	22079267	124284755	28	6099											
PCMTD1	115294	broad.mit.edu	37	chr8	52733107	52733107	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaggctgaggaataagctgaTtacccacaaatacgtaagtg	11	7	0	2			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr8:52733107T>C	uc003xqx.3	-	6	1219	c.878A>G	c.(877-879)AAT>AGT	p.N293S	PCMTD1_uc011ldm.1_Missense_Mutation_p.N163S|PCMTD1_uc003xqw.3_Missense_Mutation_p.N293S|PCMTD1_uc011ldn.1_Missense_Mutation_p.N105S|PCMTD1_uc010lya.2_Missense_Mutation_p.N217S	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	293						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				AATAAGCTGATTACCCACAAA	0.318													C	52733107	C	C	52733107	3	2	91	1	0	0	0	0	1	0	0	0	11586	1493	52	4	199	4	PCMTD1	8	52733107	Missense_Mutation	SNP	T	TCGA-06-5414-01A-01D-1486-08	30653840	52733107	93630915	29	6100											
KCNB2	9312	broad.mit.edu	37	chr8	73848231	73848231	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattgctttgtctctcaataCgctgccggagctgcaggaaa	10	11	2	0			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr8:73848231C>T	uc003xzb.2	+	3	1229	c.641C>T	c.(640-642)ACG>ATG	p.T214M		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	214					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TCTCTCAATACGCTGCCGGAG	0.478													T	73848231	T	T	73848231	3	4	91	1	0	0	0	0	1	0	0	0	8013	536	19	1	647	1	KCNB2	8	73848231	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08	21115124	73848231	72515791	30	6101											
KCNK18	338567	broad.mit.edu	37	chr10	118969028	118969028	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctatggctacatctaccccGtcaccaggcttggcaagtac	9	14	2	0	rs141958329		TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr10:118969028G>A	uc010qsr.1	+	3	373	c.373G>A	c.(373-375)GTC>ATC	p.V125I		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	125						integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CATCTACCCCGTCACCAGGCT	0.507													A	118969028	A	A	118969028	3	1	91	1	0	0	0	0	1	0	0	0	8065	1145	40	1	383	1	KCNK18	10	118969028	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08		118969028	16565719	31	6102											
ZNF215	7762	broad.mit.edu	37	chr11	6964441	6964441	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taggaacctgaattcattgcGtaaaggtggtttctatatgt	10	5	2	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr11:6964441G>A	uc001mey.2	+	5	1199	c.611G>A	c.(610-612)CGT>CAT	p.R204H	ZNF215_uc010raw.1_Intron|ZNF215_uc010rax.1_Intron|ZNF215_uc001mez.1_Missense_Mutation_p.R204H	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	204	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		AATTCATTGCGTAAAGGTGGT	0.418													A	6964441	A	A	6964441	3	1	91	1	0	0	0	0	1	0	0	0	17768	1145	40	1	621	1	ZNF215	11	6964441	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08		6964441	128042075	32	6103											
OLFML1	283298	broad.mit.edu	37	chr11	7509544	7509544	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgactacatacaataccttCgagaggctgacgagtgcatc	9	10	0	3			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr11:7509544C>T	uc001mfi.2	+	2	668	c.316C>T	c.(316-318)CGA>TGA	p.R106*	uc001mff.1_Intron|OLFML1_uc001mfh.1_Nonsense_Mutation_p.R106*|OLFML1_uc010raz.1_Intron|OLFML1_uc010rba.1_Nonsense_Mutation_p.R106*	NM_198474	NP_940876	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1 precursor	106	Potential.					extracellular region				ovary(2)	2				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		ACAATACCTTCGAGAGGCTGA	0.478													T	7509544	T	T	7509544	4	4	91	1	0	0	0	0	0	1	0	0	10856	876	31	2	322	2	OLFML1	11	7509544	Nonsense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08	545103	7509544	127496972	33	6104											
OR4P4	81300	broad.mit.edu	37	chr11	55406751	55406751	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tggtgttgtcaaatactcctGaaaagaaatcaacttttctg	7	7	3	2			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr11:55406751G>T	uc010rij.1	+	1	918	c.918G>T	c.(916-918)CTG>CTT	p.L306L		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AAATACTCCTGAAAAGAAATC	0.398													T	55406751	T	T	55406751	2	4	91	1	0	0	0	0	0	0	0	1	11080	1277	45	5		5	OR4P4	11	55406751	Silent	SNP	G	TCGA-06-5414-01A-01D-1486-08	47897207	55406751	79599765	34	6105											
LRRC55	219527	broad.mit.edu	37	chr11	56950136	56950136	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgaagtggctgcgaaacCggatccagcgctgtacagca	13	11	0	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr11:56950136C>T	uc001njl.1	+	1	916	c.769C>T	c.(769-771)CGG>TGG	p.R257W		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	227	LRRCT.					integral to membrane					0						GCTGCGAAACCGGATCCAGCG	0.617													T	56950136	T	T	56950136	3	4	91	1	0	0	0	0	1	0	0	0	9011	643	23	2	771	2	LRRC55	11	56950136	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08	1543385	56950136	78056380	35	6106											
LRP5	4041	broad.mit.edu	37	chr11	68206026	68206026	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgtctattttgtgtgccaGcgcgtggtgtgccagcgcta	15	9	1	0			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr11:68206026G>A	uc001ont.2	+	20	4299	c.4224G>A	c.(4222-4224)CAG>CAA	p.Q1408Q	LRP5_uc009ysg.2_Silent_p.Q818Q	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1408	Cytoplasmic (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						TTGTGTGCCAGCGCGTGGTGT	0.652													A	68206026	A	A	68206026	2	1	91	1	0	0	0	0	0	0	0	1	8960	962	34	3		3	LRP5	11	68206026	Silent	SNP	G	TCGA-06-5414-01A-01D-1486-08	11255890	68206026	66800490	36	6107											
KDELC2	143888	broad.mit.edu	37	chr11	108350192	108350192	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggatatctgtaagcagccaCggtcccatccacatttactt	7	12	1	0			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr11:108350192C>T	uc001pkj.2	-	6	1195	c.1129G>A	c.(1129-1131)GTG>ATG	p.V377M	KDELC2_uc001pki.2_Missense_Mutation_p.V321M	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	377						endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		TAAGCAGCCACGGTCCCATCC	0.408													T	108350192	T	T	108350192	3	4	91	1	0	0	0	0	1	0	0	0	8118	536	19	1	406	1	KDELC2	11	108350192	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08	40144166	108350192	26656324	37	6108											
USP2	9099	broad.mit.edu	37	chr11	119229846	119229846	+	Splice_Site	DEL	T	-	-													ctcctgagcatcctgctgacTgaacccaaaggaaggagggt							TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr11:119229846delT	uc001pwm.3	-	6	1357	c.1062_splice	c.e6-1	p.N354_splice	USP2_uc001pwl.3_Splice_Site_p.N145_splice|USP2_uc001pwn.3_Splice_Site_p.N111_splice	NM_004205	NP_004196	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2 isoform a						cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			ovary(2)|urinary_tract(1)|skin(1)	4		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		TCCTGCTGACTGAACCCAAAG	0.527													-	119229846	-	-	119229846	8	5	91	1	0	1	0	1	0	0	1	0	17048	1594	55	0	789	0	USP2	11	119229846	Splice_Site	DEL	T	TCGA-06-5414-01A-01D-1486-08	10879654	119229846	15776670	38	6109											
DIAPH3	81624	broad.mit.edu	37	chr13	60545255	60545256	+	Missense_Mutation	DNP	GA	AT	AT													agttccaccttctttagaggGaggcaaaggaatattacaat							TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr13:60545255_60545256GA>AT	uc001vht.2	-	16	1908_1909	c.1689_1690TC>AT	c.(1687-1692)CCTCCC>CCATCC	p.P564S	DIAPH3_uc001vhu.2_Missense_Mutation_p.P301S|DIAPH3_uc001vhv.2_Missense_Mutation_p.P142S	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	564	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TCTTTAGAGGGAGGCAAAGGAA	0.495													AT	60545256	AT	AT	60545255	3	1	91	1	0	0	0	0	1	0	0	0	4520	1174	41	3	1963	3	DIAPH3	13	60545255	Missense_Mutation	DNP	GA	TCGA-06-5414-01A-01D-1486-08		60545255	54624623	39	6110											
SLITRK1	114798	broad.mit.edu	37	chr13	84455310	84455310	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcttgttgttgttgatgtgCagccttttcaccagctgcag	10	9	2	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr13:84455310C>A	uc001vlk.2	-	1	1219	c.333G>T	c.(331-333)CTG>CTT	p.L111L		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	111	Extracellular (Potential).|LRR 3.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TGTTGATGTGCAGCCTTTTCA	0.433													A	84455310	A	A	84455310	2	1	91	1	0	0	0	0	0	0	0	1	14742	697	25	5		5	SLITRK1	13	84455310	Silent	SNP	C	TCGA-06-5414-01A-01D-1486-08	23910055	84455310	30714568	40	6111											
SLC39A9	55334	broad.mit.edu	37	chr14	69920026	69920026	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctggttgtccatgctgcaGgtagggttggattgcagtgg	17	6	1	0			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr14:69920026G>A	uc001xle.2	+	4	1152	c.472G>A	c.(472-474)GCT>ACT	p.A158T	SLC39A9_uc010aqx.2_Intron|SLC39A9_uc001xlf.3_Missense_Mutation_p.A158T|SLC39A9_uc001xlg.3_RNA	NM_018375	NP_060845	Q9NUM3	S39A9_HUMAN	solute carrier family 39 (zinc transporter),	158	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		CCATGCTGCAGGTAGGGTTGG	0.463													A	69920026	A	A	69920026	3	1	91	1	0	0	0	0	1	0	0	0	14625	1014	35	3	486	3	SLC39A9	14	69920026	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08		69920026	37429514	41	6112											
TCF12	6938	broad.mit.edu	37	chr15	57524624	57524624	+	Frame_Shift_Del	DEL	G	-	-													caaccttcattcacatgaccGcttggtaggctataacacgt							TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr15:57524624delG	uc002aec.2	+	10	1105	c.821delG	c.(820-822)CGCfs	p.R274fs	TCF12_uc010ugm.1_Frame_Shift_Del_p.R326fs|TCF12_uc010ugn.1_Frame_Shift_Del_p.R270fs|TCF12_uc002aea.2_Frame_Shift_Del_p.R274fs|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Frame_Shift_Del_p.R274fs|TCF12_uc002aed.2_Frame_Shift_Del_p.R274fs|TCF12_uc002aee.2_Frame_Shift_Del_p.R104fs|TCF12_uc010bft.2_Frame_Shift_Del_p.R104fs|TCF12_uc010ugo.1_Intron	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	274					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		TCACATGACCGCTTGGTAGGC	0.443			T	TEC	extraskeletal myxoid chondrosarcoma								-	57524624	-	-	57524624	7	5	91	1	0	1	0	1	0	0	0	0	15684	1087	38	0	928	0	TCF12	15	57524624	Frame_Shift_Del	DEL	G	TCGA-06-5414-01A-01D-1486-08		57524624	45006768	42	6113											
KRT13	3860	broad.mit.edu	37	chr17	39659673	39659673	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcggcctccacgctctggcGcagggccagctcattctcat	11	16	3	0			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr17:39659673G>A	uc002hwu.1	-	3	664	c.601C>T	c.(601-603)CGC>TGC	p.R201C	KRT13_uc002hwv.1_Missense_Mutation_p.R201C|KRT13_uc002hww.2_Missense_Mutation_p.R94C|KRT13_uc010wfr.1_Missense_Mutation_p.R94C|KRT13_uc010cxo.2_Missense_Mutation_p.R201C|KRT13_uc002hwx.1_Missense_Mutation_p.R189C	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	201	Coil 1B.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				ACGCTCTGGCGCAGGGCCAGC	0.483													A	39659673	A	A	39659673	3	1	91	1	0	0	0	0	1	0	0	0	8450	1087	38	1	799	1	KRT13	17	39659673	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08		39659673	41535537	43	6114											
CNDP2	55748	broad.mit.edu	37	chr18	72178127	72178127	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctagacgagctgatttttgCccggaaagacacattcttta	8	10	1	3			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr18:72178127C>T	uc002llm.1	+	6	698	c.536C>T	c.(535-537)GCC>GTC	p.A179V	CNDP2_uc002lln.1_Missense_Mutation_p.A95V|CNDP2_uc010dqs.2_Missense_Mutation_p.A15V	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	179						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CTGATTTTTGCCCGGAAAGAC	0.527													T	72178127	T	T	72178127	3	4	91	1	0	0	0	0	1	0	0	0	3594	739	26	3	554	3	CNDP2	18	72178127	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08		72178127	5899121	44	6115											
ATG4D	84971	broad.mit.edu	37	chr19	10657548	10657548	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgagggcatgggcctgggccCccctgagctgtcagggtcag	17	13	2	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr19:10657548C>T	uc002mov.2	+	4	647	c.527C>T	c.(526-528)CCC>CTC	p.P176L	ATG4D_uc010xlg.1_Missense_Mutation_p.P199L|ATG4D_uc010xlh.1_Missense_Mutation_p.P113L|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_Intron|ATG4D_uc010dxj.2_Intron	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	176					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GGCCTGGGCCCCCCTGAGCTG	0.657													T	10657548	T	T	10657548	3	4	91	1	0	0	0	0	1	0	0	0	1099	623	22	3	541	3	ATG4D	19	10657548	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08		10657548	48471435	45	6116											
NWD1	284434	broad.mit.edu	37	chr19	16883984	16883984	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggccagactccatttcttcGccacctcacatccagcactg	6	17	2	1	rs139109286	by1000genomes	TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr19:16883984G>A	uc002neu.3	+	11	2880	c.2458G>A	c.(2458-2460)GCC>ACC	p.A820T	NWD1_uc002net.3_Missense_Mutation_p.A685T|NWD1_uc002nev.3_Missense_Mutation_p.A614T			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	820							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CCATTTCTTCGCCACCTCACA	0.577													A	16883984	A	A	16883984	3	1	91	1	0	0	0	0	1	0	0	0	10781	1087	38	1	2079	1	NWD1	19	16883984	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08	6226436	16883984	42244999	46	6117											
MEGF8	1954	broad.mit.edu	37	chr19	42879827	42879827	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgcactgtcctctttggcGtgcagcccaaattcaccaac	8	16	2	0			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr19:42879827G>A	uc002otl.3	+	41	7872	c.7237G>A	c.(7237-7239)GTG>ATG	p.V2413M	MEGF8_uc002otm.3_Missense_Mutation_p.V2021M|MEGF8_uc002otn.3_Missense_Mutation_p.V74M	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2480	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				CCTCTTTGGCGTGCAGCCCAA	0.637													A	42879827	A	A	42879827	3	1	91	1	0	0	0	0	1	0	0	0	9463	1145	40	1	7399	1	MEGF8	19	42879827	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08	25995843	42879827	16249156	47	6118											
ZNF665	79788	broad.mit.edu	37	chr19	53668521	53668521	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atactgagtgaaaaccttgaCgcattcattacatttgaaag	7	7	1	4			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr19:53668521C>T	uc010eqm.1	-	4	1322	c.1222G>A	c.(1222-1224)GTC>ATC	p.V408I		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	343	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		AAAACCTTGACGCATTCATTA	0.398													T	53668521	T	T	53668521	3	4	91	1	0	0	0	0	1	0	0	0	18070	536	19	1	818	1	ZNF665	19	53668521	Missense_Mutation	SNP	C	TCGA-06-5414-01A-01D-1486-08	10788694	53668521	5460462	48	6119											
HCK	3055	broad.mit.edu	37	chr20	30674471	30674471	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aaggtggcagtgaagacgatGaagccagggagcatgtcggt	17	6	0	3			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr20:30674471G>A	uc002wxh.2	+	9	1047	c.876G>A	c.(874-876)ATG>ATA	p.M292I	HCK_uc010gdy.2_Missense_Mutation_p.M271I|HCK_uc002wxi.2_Missense_Mutation_p.M270I	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	292	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TGAAGACGATGAAGCCAGGGA	0.577													A	30674471	A	A	30674471	3	1	91	1	0	0	0	0	1	0	0	0	6994	1290	45	3	916	3	HCK	20	30674471	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08		30674471	32351049	49	6120											
PPARA	5465	broad.mit.edu	37	chr22	46594404	46594404	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagagatttcgcaatccatcGgcgaggatagttctggaagc	12	8	1	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chr22:46594404G>A	uc003bgw.1	+	4	390	c.124G>A	c.(124-126)GGC>AGC	p.G42S	PPARA_uc003bgx.1_Missense_Mutation_p.G42S|PPARA_uc010hab.1_Missense_Mutation_p.G42S|PPARA_uc003bgy.1_RNA|PPARA_uc003bgz.1_RNA|PPARA_uc003bha.2_Missense_Mutation_p.G42S|PPARA_uc003bhb.1_Missense_Mutation_p.G42S|PPARA_uc010hac.1_5'UTR	NM_005036	NP_005027	Q07869	PPARA_HUMAN	peroxisome proliferative activated receptor,	42					fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	GCAATCCATCGGCGAGGATAG	0.527													A	46594404	A	A	46594404	3	1	91	1	0	0	0	0	1	0	0	0	12297	1116	39	2	126	2	PPARA	22	46594404	Missense_Mutation	SNP	G	TCGA-06-5414-01A-01D-1486-08		46594404	4710162	50	6121											
CNKSR2	22866	broad.mit.edu	37	chrX	21508621	21508621	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaccacatcatatccctgtcGtcagatcctctggtttcaca	6	14	4	1			TCGA-06-5414-01A-01D-1486-08	TCGA-06-5414-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	7aa16ff4-169a-4206-83d1-a2495fb56f62	0489fea8-8d1b-4258-b083-e6f646246abc	g.chrX:21508621G>T	uc004czx.1	+	6	642	c.606G>T	c.(604-606)TCG>TCT	p.S202S	CNKSR2_uc004czw.2_Silent_p.S202S|CNKSR2_uc011mjn.1_Silent_p.S202S|CNKSR2_uc011mjo.1_Silent_p.S202S	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	202					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						TATCCCTGTCGTCAGATCCTC	0.398													T	21508621	T	T	21508621	2	4	91	1	0	0	0	0	0	0	0	1	3607	1132	40	5		5	CNKSR2	23	21508621	Silent	SNP	G	TCGA-06-5414-01A-01D-1486-08		21508621	133761939	51	6122											
MIB2	142678	broad.mit.edu	37	chr1	1563750	1563750	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctgccctcaacaaccacCgcgaggtggcccagatcctc	10	17	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:1563750C>T	uc001agg.2	+	15	2240	c.2113C>T	c.(2113-2115)CGC>TGC	p.R705C	MIB2_uc001agh.2_Missense_Mutation_p.R691C|MIB2_uc001agi.2_Missense_Mutation_p.R701C|MIB2_uc001agj.2_Missense_Mutation_p.R546C|MIB2_uc001agk.2_Missense_Mutation_p.R640C|MIB2_uc001agl.1_Missense_Mutation_p.R661C|MIB2_uc001agm.2_Missense_Mutation_p.R582C|MIB2_uc010nyq.1_Missense_Mutation_p.R661C|MIB2_uc009vkh.2_Missense_Mutation_p.R511C|MIB2_uc001agn.2_Missense_Mutation_p.R337C|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	705	ANK 6.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAACAACCACCGCGAGGTGGC	0.692													T	1563750	T	T	1563750	3	4	92	1	0	0	0	0	1	0	0	0	9567	652	23	2	2342	2	MIB2	1	1563750	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		1563750	247686871	1	6123											
PLEKHG5	57449	broad.mit.edu	37	chr1	6537601	6537601	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtgctcaccttgtgggggaaGgtcgaagcggacatgcccat	15	10	1	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:6537601G>C	uc001ano.1	-	3	300	c.199C>G	c.(199-201)CTT>GTT	p.L67V	PLEKHG5_uc001ann.1_Missense_Mutation_p.L48V|PLEKHG5_uc001anq.1_Missense_Mutation_p.L88V|PLEKHG5_uc001anp.1_Missense_Mutation_p.L88V|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_Missense_Mutation_p.L80V|PLEKHG5_uc001ank.1_Missense_Mutation_p.L11V|PLEKHG5_uc009vmb.1_Missense_Mutation_p.L11V|PLEKHG5_uc001anl.1_Missense_Mutation_p.L11V|PLEKHG5_uc001anm.1_Missense_Mutation_p.L11V	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	67					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		TGTGGGGGAAGGTCGAAGCGG	0.537													C	6537601	C	C	6537601	3	2	92	1	0	0	0	0	1	0	0	0	12073	1000	35	5	3069	5	PLEKHG5	1	6537601	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	4973851	6537601	242713020	2	6124											
CD53	963	broad.mit.edu	37	chr1	111435024	111435024	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgatccacaacaacttcGgagtgctcttccataacctc	6	14	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:111435024G>A	uc001dzw.2	+	4	292	c.121G>A	c.(121-123)GGA>AGA	p.G41R	CD53_uc001dzx.2_Missense_Mutation_p.G41R|CD53_uc010owa.1_Missense_Mutation_p.G41R|CD53_uc001dzy.2_Missense_Mutation_p.G41R	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	41	Extracellular (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		CAACAACTTCGGAGTGCTCTT	0.507													A	111435024	A	A	111435024	3	1	92	1	0	0	0	0	1	0	0	0	3023	1117	39	2	127	2	CD53	1	111435024	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	104897423	111435024	137815597	3	6125											
HSD3B2	3284	broad.mit.edu	37	chr1	119985580	119985580	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgaagagagcctgccaggaCgtgtcggtcgtcatccacac	12	13	1	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:119985580C>T	uc001ehu.2	+	4	529	c.387C>T	c.(385-387)GAC>GAT	p.D129D				P26439	3BHS2_HUMAN	RecName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; AltName: Full=3-beta-HSD II; Includes:   RecName: Full=3-beta-hydroxy-Delta(5)-steroid dehydrogenase;            EC=1.1.1.145;   AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase;   AltName: Full=Progesterone reductase; Includes:   RecName: Full=Steroid Delta-isomerase;            EC=5.3.3.1;   AltName: Full=Delta-5-3-ketosteroid isomerase;	Error:Variant_position_missing_in_P26439_after_alignment					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CCTGCCAGGACGTGTCGGTCG	0.507													T	119985580	T	T	119985580	2	4	92	1	0	0	0	0	0	0	0	1	7391	551	19	1		1	HSD3B2	1	119985580	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	8550556	119985580	129265041	4	6126											
HRNR	388697	broad.mit.edu	37	chr1	152188024	152188024	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gctccatgttggccacagctCgatgactgtcctgatgcaga	11	12	0	3	rs142170860		TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:152188024C>G	uc001ezt.1	-	3	6157	c.6081G>C	c.(6079-6081)TCG>TCC	p.S2027S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2027	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCACAGCTCGATGACTGTC	0.562													G	152188024	G	G	152188024	2	3	92	1	0	0	0	0	0	0	0	1	7359	871	31	5		5	HRNR	1	152188024	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	32202444	152188024	97062597	5	6127											
NUP210L	91181	broad.mit.edu	37	chr1	154090286	154090286	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctgacctgcagtcaccactCctttcgtggttactatgacc	7	15	1	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:154090286C>T	uc001fdw.2	-	12	1607	c.1535G>A	c.(1534-1536)GGA>GAA	p.G512E	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.G512E	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	512						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AGTCACCACTCCTTTCGTGGT	0.433													T	154090286	T	T	154090286	3	4	92	1	0	0	0	0	1	0	0	0	10761	855	30	3	4247	3	NUP210L	1	154090286	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08	1902262	154090286	95160335	6	6128											
TIPRL	261726	broad.mit.edu	37	chr1	168165850	168165850	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agaattgatggggtgcttatCagaatgaatgacacgagact	12	5	1	6			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:168165850C>A	uc001gfg.2	+	5	727	c.582C>A	c.(580-582)ATC>ATA	p.I194I	TIPRL_uc001gfh.2_Silent_p.I194I	NM_152902	NP_690866	O75663	TIPRL_HUMAN	TIP41, TOR signalling pathway regulator-like	194	Interaction with PPP2CA.				DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			ovary(1)	1	all_hematologic(923;0.215)					GGGTGCTTATCAGAATGAATG	0.323													A	168165850	A	A	168165850	2	1	92	1	0	0	0	0	0	0	0	1	15923	816	29	5		5	TIPRL	1	168165850	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	14075564	168165850	81084771	7	6129											
USH2A	7399	broad.mit.edu	37	chr1	215933077	215933077	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaaagcaagtttccattaCgactcaattgatattgagaa	8	6	1	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:215933077C>T	uc001hku.1	-	57	11543	c.11156G>A	c.(11155-11157)CGT>CAT	p.R3719H		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3719	Fibronectin type-III 22.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTTCCATTACGACTCAATTG	0.408										HNSCC(13;0.011)			T	215933077	T	T	215933077	3	4	92	1	0	0	0	0	1	0	0	0	17033	536	19	1	4516	1	USH2A	1	215933077	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08	47767227	215933077	33317544	8	6130											
EPHX1	2052	broad.mit.edu	37	chr1	226027611	226027611	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcctcctgggacagcgtttCgggaggtttcttggcctcac	12	13	2	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:226027611C>T	uc001hpk.2	+	6	884	c.804C>T	c.(802-804)TTC>TTT	p.F268F	EPHX1_uc001hpl.2_Silent_p.F268F	NM_001136018	NP_001129490	P07099	HYEP_HUMAN	epoxide hydrolase 1	268					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			ovary(3)|lung(1)	4	Breast(184;0.197)					GACAGCGTTTCGGGAGGTTTC	0.552													T	226027611	T	T	226027611	2	4	92	1	0	0	0	0	0	0	0	1	5179	883	31	2		2	EPHX1	1	226027611	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	10094534	226027611	23223010	9	6131											
RYR2	6262	broad.mit.edu	37	chr1	237838075	237838075	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cacgccttctattgagaaacGatttgcctatagtttcctcc	6	12	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr1:237838075G>A	uc001hyl.1	+	60	8879	c.8759G>A	c.(8758-8760)CGA>CAA	p.R2920Q	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2920	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.|4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATTGAGAAACGATTTGCCTAT	0.423													A	237838075	A	A	237838075	3	1	92	1	0	0	0	0	1	0	0	0	13769	1058	37	2	8997	2	RYR2	1	237838075	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	11810464	237838075	11412546	10	6132											
SNTG2	54221	broad.mit.edu	37	chr2	1271318	1271318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagtccttccaaagagccaCgttcatggaagttcagagaa	10	9	2	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr2:1271318C>T	uc002qwq.2	+	14	1387	c.1259C>T	c.(1258-1260)ACG>ATG	p.T420M	SNTG2_uc010ewi.2_Missense_Mutation_p.T293M	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	420	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CAAAGAGCCACGTTCATGGAA	0.527													T	1271318	T	T	1271318	3	4	92	1	0	0	0	0	1	0	0	0	14875	536	19	1	1313	1	SNTG2	2	1271318	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		1271318	241928055	11	6133											
TTN	7273	broad.mit.edu	37	chr2	179425883	179425883	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcattccttgcaaaaacccGgaattcataacgctgatctt	6	11	2	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr2:179425883G>A	uc010zfg.1	-	275	77496	c.77272C>T	c.(77272-77274)CGG>TGG	p.R25758W	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R19453W|TTN_uc010zfi.1_Missense_Mutation_p.R19386W|TTN_uc010zfj.1_Missense_Mutation_p.R19261W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26685							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAAAAACCCGGAATTCATAA	0.403													A	179425883	A	A	179425883	3	1	92	1	0	0	0	0	1	0	0	0	16732	1115	39	2	23151	2	TTN	2	179425883	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	178154565	179425883	63773490	12	6134											
NMUR1	10316	broad.mit.edu	37	chr2	232393454	232393454	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggtagtagttggtaggcGtgcgcatggccttgtggcgc	18	7	0	1	rs143358901	by1000genomes	TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr2:232393454G>A	uc002vry.3	-	2	388	c.278C>T	c.(277-279)ACG>ATG	p.T93M		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	93	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		GTTGGTAGGCGTGCGCATGGC	0.612													A	232393454	A	A	232393454	3	1	92	1	0	0	0	0	1	0	0	0	10506	1145	40	1	1010	1	NMUR1	2	232393454	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	52967571	232393454	10805919	13	6135											
PTPRG	5793	broad.mit.edu	37	chr3	62188854	62188854	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaccctttccagcccacagCgtctcctgcctcttcagccg	7	19	3	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr3:62188854C>T	uc003dlb.2	+	12	2104	c.1385C>T	c.(1384-1386)GCG>GTG	p.A462V	PTPRG_uc003dlc.2_Missense_Mutation_p.A462V	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	462	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CAGCCCACAGCGTCTCCTGCC	0.547													T	62188854	T	T	62188854	3	4	92	1	0	0	0	0	1	0	0	0	12802	768	27	1	1431	1	PTPRG	3	62188854	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		62188854	135833576	14	6136											
STAG1	10274	broad.mit.edu	37	chr3	136076625	136076625	+	Frame_Shift_Del	DEL	A	-	-													ttagtacttcaagaaaagccAgattaggaggtggatactct							TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr3:136076625delA	uc003era.1	-	28	3294	c.3002delT	c.(3001-3003)CTGfs	p.L1001fs	STAG1_uc003erb.1_Frame_Shift_Del_p.L1001fs	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1001					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						AAGAAAAGCCAGATTAGGAGG	0.333													-	136076625	-	-	136076625	7	5	92	1	0	1	0	1	0	0	0	0	15241	188	7	0	802	0	STAG1	3	136076625	Frame_Shift_Del	DEL	A	TCGA-06-5415-01A-01D-1486-08	73887771	136076625	61945805	15	6137											
BMP3	651	broad.mit.edu	37	chr4	81952456	81952456	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccatggctggggcgagcagGctgctctttctgtggctggg	18	10	2	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr4:81952456G>A	uc003hmg.3	+	1	338	c.18G>A	c.(16-18)AGG>AGA	p.R6R		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	6					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						GGGCGAGCAGGCTGCTCTTTC	0.706													A	81952456	A	A	81952456	2	1	92	1	0	0	0	0	0	0	0	1	1461	1194	42	3		3	BMP3	4	81952456	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08		81952456	109201820	16	6138											
MTTP	4547	broad.mit.edu	37	chr4	100534247	100534247	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaatgctgtcagcatctggcGaccctatcagtgtggtgaaa	11	9	3	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr4:100534247G>A	uc003hvc.3	+	16	2423	c.2167G>A	c.(2167-2169)GAC>AAC	p.D723N	MTTP_uc011cej.1_Missense_Mutation_p.D750N	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	723					lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	AGCATCTGGCGACCCTATCAG	0.338													A	100534247	A	A	100534247	3	1	92	1	0	0	0	0	1	0	0	0	9964	1058	37	2	2225	2	MTTP	4	100534247	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	18581791	100534247	90620029	17	6139											
TLL1	7092	broad.mit.edu	37	chr4	166915601	166915601	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagggcaaaatgagaaaaatCgagttcccagagccgctaca	10	10	0	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr4:166915601C>T	uc003irh.1	+	4	1077	c.430C>T	c.(430-432)CGA>TGA	p.R144*	TLL1_uc011cjn.1_Nonsense_Mutation_p.R144*|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	144					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGAGAAAAATCGAGTTCCCAG	0.423													T	166915601	T	T	166915601	4	4	92	1	0	0	0	0	0	1	0	0	15942	876	31	2	444	2	TLL1	4	166915601	Nonsense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08	66381354	166915601	24238675	18	6140											
PDE8B	8622	broad.mit.edu	37	chr5	76640735	76640735	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catgaagccatagaaataacAagcgatgaccacgtgattca	8	9	1	4			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr5:76640735A>G	uc003kfa.2	+	7	900	c.855A>G	c.(853-855)ACA>ACG	p.T285T	PDE8B_uc003kfb.2_Silent_p.T265T|PDE8B_uc003kfc.2_Silent_p.T285T|PDE8B_uc003kfd.2_Silent_p.T285T|PDE8B_uc003kfe.2_Silent_p.T285T	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	285	PAS.				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		TAGAAATAACAAGCGATGACC	0.353													G	76640735	G	G	76640735	2	3	92	1	0	0	0	0	0	0	0	1	11654	117	5	4		4	PDE8B	5	76640735	Silent	SNP	A	TCGA-06-5415-01A-01D-1486-08		76640735	104274525	19	6141											
RASA1	5921	broad.mit.edu	37	chr5	86659220	86659220	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttagagggtagtgatgcccaActtatttattttgaaagcga	10	5	0	3			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr5:86659220A>G	uc003kiw.2	+	11	1627	c.1509A>G	c.(1507-1509)CAA>CAG	p.Q503Q	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Silent_p.Q326Q|RASA1_uc011ctv.1_Silent_p.Q336Q|RASA1_uc011ctw.1_Silent_p.Q337Q|RASA1_uc010jaw.2_Silent_p.Q325Q	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	503	PH.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GTGATGCCCAACTTATTTATT	0.323													G	86659220	G	G	86659220	2	3	92	1	0	0	0	0	0	0	0	1	13060	40	2	4		4	RASA1	5	86659220	Silent	SNP	A	TCGA-06-5415-01A-01D-1486-08	10018485	86659220	94256040	20	6142											
GPR98	84059	broad.mit.edu	37	chr5	89986845	89986845	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcctggctgacgacgttcCggagattgaagaggtgagag	17	7	0	5			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr5:89986845C>T	uc003kju.2	+	31	7034	c.6938C>T	c.(6937-6939)CCG>CTG	p.P2313L	GPR98_uc003kjt.2_Intron|GPR98_uc003kjv.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2313	Calx-beta 16.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GACGACGTTCCGGAGATTGAA	0.468													T	89986845	T	T	89986845	3	4	92	1	0	0	0	0	1	0	0	0	6721	652	23	2	7060	2	GPR98	5	89986845	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08	3327625	89986845	90928415	21	6143											
TRPC7	57113	broad.mit.edu	37	chr5	135583350	135583350	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtatgcaatgcgagagaaGctcagcacgacggctatcgc	12	10	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr5:135583350G>A	uc003lbn.1	-	6	1653	c.1650C>T	c.(1648-1650)AGC>AGT	p.S550S	TRPC7_uc010jef.1_Silent_p.S487S|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Silent_p.S481S|TRPC7_uc010jei.1_Silent_p.S426S|TRPC7_uc010jej.1_Silent_p.S102S	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	551	Helical; (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGCGAGAGAAGCTCAGCACGA	0.502													A	135583350	A	A	135583350	2	1	92	1	0	0	0	0	0	0	0	1	16581	962	34	3		3	TRPC7	5	135583350	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08	45596505	135583350	45331910	22	6144											
GABRA1	2554	broad.mit.edu	37	chr5	161324264	161324264	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aacctaaagaggtcaagcccGaaacaaaaccaccagaaccc	6	14	1	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr5:161324264G>A	uc010jiw.2	+	11	1675	c.1207G>A	c.(1207-1209)GAA>AAA	p.E403K	GABRA1_uc010jix.2_Missense_Mutation_p.E403K|GABRA1_uc010jiy.2_Missense_Mutation_p.E403K|GABRA1_uc003lyx.3_Missense_Mutation_p.E403K|GABRA1_uc010jiz.2_Missense_Mutation_p.E403K|GABRA1_uc010jja.2_Missense_Mutation_p.E403K|GABRA1_uc010jjb.2_Missense_Mutation_p.E403K	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	403	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	GGTCAAGCCCGAAACAAAACC	0.473													A	161324264	A	A	161324264	3	1	92	1	0	0	0	0	1	0	0	0	6160	1059	37	2	1241	2	GABRA1	5	161324264	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	25740914	161324264	19590996	23	6145											
CUL9	23113	broad.mit.edu	37	chr6	43181519	43181519	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtggctgatacctccccagGcatacctgaacgtagagaag	11	11	0	3			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr6:43181519G>A	uc003ouk.2	+	29	5632	c.5557G>A	c.(5557-5559)GCA>ACA	p.A1853T	CUL9_uc003oul.2_Intron|CUL9_uc010jyk.2_Missense_Mutation_p.A1005T|CUL9_uc003oun.2_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1853				Missing (in Ref. 3; CAH18696).	ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						ACCTCCCCAGGCATACCTGAA	0.577													A	43181519	A	A	43181519	3	1	92	1	0	0	0	0	1	0	0	0	4061	1203	42	3	5667	3	CUL9	6	43181519	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08		43181519	127933548	24	6146											
CLIC5	53405	broad.mit.edu	37	chr6	45882070	45882070	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttccccacaagtgttggcGtcaatctcctctggtagagg	10	12	4	1	rs146052023		TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr6:45882070G>A	uc003oxv.3	-	5	1066	c.960C>T	c.(958-960)GAC>GAT	p.D320D	CLIC5_uc003oxu.3_Silent_p.D161D|CLIC5_uc003oxw.2_RNA|CLIC5_uc003oxx.2_Silent_p.D161D	NM_001114086	NP_001107558	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5 isoform a	320	GST C-terminal.				female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			ovary(1)|skin(1)	2						AAGTGTTGGCGTCAATCTCCT	0.537													A	45882070	A	A	45882070	2	1	92	1	0	0	0	0	0	0	0	1	3529	1136	40	1		1	CLIC5	6	45882070	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08	2700551	45882070	125232997	25	6147											
STX7	8417	broad.mit.edu	37	chr6	132792715	132792715	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtgaactctgccactaagcGatccttctgtattttccttt	6	11	2	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr6:132792715G>A	uc003qdg.2	-	5	524	c.274C>T	c.(274-276)CGC>TGC	p.R92C	STX7_uc011ecg.1_Intron|STX7_uc011ech.1_Intron	NM_003569	NP_003560	O15400	STX7_HUMAN	syntaxin 7	92	Cytoplasmic (Potential).				intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity				0	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		GCCACTAAGCGATCCTTCTGT	0.453													A	132792715	A	A	132792715	3	1	92	1	0	0	0	0	1	0	0	0	15349	1058	37	2	535	2	STX7	6	132792715	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	86910645	132792715	38322352	26	6148											
PDE1C	5137	broad.mit.edu	37	chr7	31890345	31890345	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagcaaagatctccagctccGtcagccagttctgaaaggag	10	11	3	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:31890345G>A	uc003tcm.1	-	8	1230	c.761C>T	c.(760-762)ACG>ATG	p.T254M	PDE1C_uc003tcn.1_Missense_Mutation_p.T254M|PDE1C_uc003tco.1_Missense_Mutation_p.T314M|PDE1C_uc003tcr.2_Missense_Mutation_p.T254M|PDE1C_uc003tcs.2_Missense_Mutation_p.T254M	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	254	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CTCCAGCTCCGTCAGCCAGTT	0.463													A	31890345	A	A	31890345	3	1	92	1	0	0	0	0	1	0	0	0	11635	1145	40	1	1183	1	PDE1C	7	31890345	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08		31890345	127248318	27	6149											
ABCA13	154664	broad.mit.edu	37	chr7	48556332	48556332	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acttttcagatatgcaactcTtccatggatgtacctgatgt	7	9	2	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:48556332T>C	uc003toq.2	+	52	13677	c.13652T>C	c.(13651-13653)CTT>CCT	p.L4551P	ABCA13_uc010kys.1_Missense_Mutation_p.L1626P|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.L281P	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4551	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TATGCAACTCTTCCATGGATG	0.294													C	48556332	C	C	48556332	3	2	92	1	0	0	0	0	1	0	0	0	31	1609	56	4	13687	4	ABCA13	7	48556332	Missense_Mutation	SNP	T	TCGA-06-5415-01A-01D-1486-08	16665987	48556332	110582331	28	6150											
STEAP2	261729	broad.mit.edu	37	chr7	89856794	89856794	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcagagagatatttgtttctCaacatggcttatcagcaggt	9	7	3	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:89856794C>T	uc003ujz.2	+	3	1395	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L	STEAP2_uc003ujy.2_Silent_p.L376L|STEAP2_uc010len.2_Silent_p.L334L|STEAP2_uc003uka.2_Silent_p.L334L|STEAP2_uc003ukb.2_Silent_p.L334L|STEAP2_uc003ukc.2_Silent_p.L334L|STEAP2_uc003ukd.2_Silent_p.L334L	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	334	Ferric oxidoreductase.				electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					ATTTGTTTCTCAACATGGCTT	0.338													T	89856794	T	T	89856794	2	4	92	1	0	0	0	0	0	0	0	1	15277	813	29	3		3	STEAP2	7	89856794	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	41300462	89856794	69281869	29	6151											
ZAN	7455	broad.mit.edu	37	chr7	100382333	100382333	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggatggccggtgtgagggCgccaaagtcccctctgcctg	15	13	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:100382333C>T	uc003uwj.2	+	37	6876	c.6711C>T	c.(6709-6711)GGC>GGT	p.G2237G	ZAN_uc003uwk.2_Silent_p.G2237G|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.G287G	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2237	Extracellular (Potential).|TIL 4.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GGTGTGAGGGCGCCAAAGTCC	0.612													T	100382333	T	T	100382333	2	4	92	1	0	0	0	0	0	0	0	1	17510	755	27	1		1	ZAN	7	100382333	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	10525539	100382333	58756330	30	6152											
IFRD1	3475	broad.mit.edu	37	chr7	112097053	112097053	+	Frame_Shift_Del	DEL	A	-	-													gaatttattctggaaaggagAatgactttaactgatagcat							TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:112097053delA	uc003vgh.2	+	5	812	c.369delA	c.(367-369)AGAfs	p.R123fs	IFRD1_uc011kmn.1_Frame_Shift_Del_p.R73fs|IFRD1_uc003vgi.2_Frame_Shift_Del_p.R123fs|IFRD1_uc003vgj.2_Frame_Shift_Del_p.R123fs|IFRD1_uc011kmo.1_RNA|IFRD1_uc011kmp.1_Frame_Shift_Del_p.R73fs	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	123					multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2						TGGAAAGGAGAATGACTTTAA	0.368													-	112097053	-	-	112097053	7	5	92	1	0	1	0	1	0	0	0	0	7553	243	9	0	383	0	IFRD1	7	112097053	Frame_Shift_Del	DEL	A	TCGA-06-5415-01A-01D-1486-08	11714720	112097053	47041610	31	6153											
FLNC	2318	broad.mit.edu	37	chr7	128490536	128490536	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgcagaaaggggagctcacAggtactgccctgtggctccc	14	12	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:128490536A>G	uc003vnz.3	+	32	5606	c.5397A>G	c.(5395-5397)ACA>ACG	p.T1799T	FLNC_uc003voa.3_Silent_p.T1766T	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1799	Filamin 16.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GGGAGCTCACAGGTACTGCCC	0.463													G	128490536	G	G	128490536	2	3	92	1	0	0	0	0	0	0	0	1	5935	202	7	4		4	FLNC	7	128490536	Silent	SNP	A	TCGA-06-5415-01A-01D-1486-08	16393483	128490536	30648127	32	6154											
FLNC	2318	broad.mit.edu	37	chr7	128493857	128493857	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcaccttccatcgccaccatCggcagcacctgtgacctcaa	7	18	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:128493857C>T	uc003vnz.3	+	39	6659	c.6450C>T	c.(6448-6450)ATC>ATT	p.I2150I	FLNC_uc003voa.3_Silent_p.I2117I	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2150					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TCGCCACCATCGGCAGCACCT	0.662													T	128493857	T	T	128493857	2	4	92	1	0	0	0	0	0	0	0	1	5935	874	31	2		2	FLNC	7	128493857	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	3321	128493857	30644806	33	6155											
C7orf49	78996	broad.mit.edu	37	chr7	134851619	134851619	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcaggccttttcctgtttgCggctctgtggagtacgggaa	14	10	1	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:134851619C>T	uc003vsl.2	-	4	485	c.218G>A	c.(217-219)CGC>CAC	p.R73H	C7orf49_uc003vsh.2_Intron|C7orf49_uc003vsj.2_Missense_Mutation_p.R44H|C7orf49_uc003vsk.2_RNA|C7orf49_uc003vsm.2_RNA|C7orf49_uc003vsn.2_Missense_Mutation_p.R72H|C7orf49_uc003vso.2_Missense_Mutation_p.R18H	NM_024033	NP_076938	Q9BWK5	MRI_HUMAN	modulator of retrovirus infection	73						cytoplasm				large_intestine(1)|ovary(1)	2						TTCCTGTTTGCGGCTCTGTGG	0.552													T	134851619	T	T	134851619	3	4	92	1	0	0	0	0	1	0	0	0	2398	768	27	1	259	1	C7orf49	7	134851619	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08	6357762	134851619	24287044	34	6156											
ATP6V0A4	50617	broad.mit.edu	37	chr7	138453573	138453573	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggggtcagtgggcttttctcGagcaactgaactacaatctc	11	10	3	1	rs137955459		TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:138453573G>A	uc003vuf.2	-	4	481	c.243C>T	c.(241-243)CTC>CTT	p.L81L	ATP6V0A4_uc003vug.2_Silent_p.L81L|ATP6V0A4_uc003vuh.2_Silent_p.L81L	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	81	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						GGCTTTTCTCGAGCAACTGAA	0.483													A	138453573	A	A	138453573	2	1	92	1	0	0	0	0	0	0	0	1	1170	1045	37	2		2	ATP6V0A4	7	138453573	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08	3601954	138453573	20685090	35	6157											
KEL	3792	broad.mit.edu	37	chr7	142658446	142658446	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggtctgggatcttgcttaCgagggccacagttctggaag	16	8	3	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr7:142658446C>T	uc003wcb.2	-	3	433	c.223_splice	c.e3+1	p.R75_splice		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase						proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					ATCTTGCTTACGAGGGCCACA	0.602													T	142658446	T	T	142658446	5	4	92	1	0	0	0	0	0	0	1	0	8142	550	19	1	2042	1	KEL	7	142658446	Splice_Site	SNP	C	TCGA-06-5415-01A-01D-1486-08	4204873	142658446	16480217	36	6158											
FAM83H	286077	broad.mit.edu	37	chr8	144810766	144810766	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccatgcgggccagggccgCggccgagggcacaagcggct	18	14	0	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr8:144810766C>T	uc003yzk.2	-	5	934	c.865G>A	c.(865-867)GCG>ACG	p.A289T	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	289					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCCAGGGCCGCGGCCGAGGGC	0.711													T	144810766	T	T	144810766	3	4	92	1	0	0	0	0	1	0	0	0	5640	768	27	1	2678	1	FAM83H	8	144810766	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		144810766	1553256	37	6159											
EPPK1	83481	broad.mit.edu	37	chr8	144940597	144940597	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacagcctcaggttgcgcacGgggtcgatgacgaagccggt	16	11	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr8:144940597G>A	uc003zaa.1	-	2	14848	c.14835C>T	c.(14833-14835)CCC>CCT	p.P4945P		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4945	Plectin 62.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTTGCGCACGGGGTCGATGA	0.721													A	144940597	A	A	144940597	2	1	92	1	0	0	0	0	0	0	0	1	5190	1103	39	2		2	EPPK1	8	144940597	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08	129831	144940597	1423425	38	6160											
MKX	283078	broad.mit.edu	37	chr10	27964299	27964299	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccatagctgcgttgatctcCttccaatacgtgtcatcctt	7	13	2	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr10:27964299C>T	uc001ity.3	-	7	1143	c.918G>A	c.(916-918)AAG>AAA	p.K306K	MKX_uc001itx.3_Silent_p.K306K	NM_173576	NP_775847	Q8IYA7	MKX_HUMAN	mohawk homeobox	306					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CGTTGATCTCCTTCCAATACG	0.458													T	27964299	T	T	27964299	2	4	92	1	0	0	0	0	0	0	0	1	9610	680	24	3		3	MKX	10	27964299	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08		27964299	107570448	39	6161											
C10orf12	26148	broad.mit.edu	37	chr10	98741746	98741746	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atactttttcaatggtgactGttgtgagctgccaactgttc	9	8	1	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr10:98741746G>A	uc001kmv.2	+	1	706	c.599G>A	c.(598-600)TGT>TAT	p.C200Y	C10orf12_uc009xvg.1_Missense_Mutation_p.C510Y	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	200										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AATGGTGACTGTTGTGAGCTG	0.423													A	98741746	A	A	98741746	3	1	92	1	0	0	0	0	1	0	0	0	1589	1377	48	3	601	3	C10orf12	10	98741746	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	70777447	98741746	36793001	40	6162											
MMP10	4319	broad.mit.edu	37	chr11	102647144	102647144	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggggttcctcagtagaggCagggggaggtcctaaaggaa	17	7	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr11:102647144C>T	uc001phg.1	-	6	821	c.799G>A	c.(799-801)GCC>ACC	p.A267T		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	267					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		TCAGTAGAGGCAGGGGGAGGT	0.468													T	102647144	T	T	102647144	3	4	92	1	0	0	0	0	1	0	0	0	9649	710	25	3	651	3	MMP10	11	102647144	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		102647144	32359372	41	6163											
DDX25	29118	broad.mit.edu	37	chr11	125787056	125787056	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacaacatccggcaatattaCgtgctgtgtgagcacaggaa	10	9	0	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr11:125787056C>T	uc001qcz.3	+	9	1089	c.948C>T	c.(946-948)TAC>TAT	p.Y316Y	DDX25_uc010sbk.1_Silent_p.Y316Y	NM_013264	NP_037396	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 25	316	Helicase C-terminal.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(1)	1	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		GGCAATATTACGTGCTGTGTG	0.478													T	125787056	T	T	125787056	2	4	92	1	0	0	0	0	0	0	0	1	4352	547	19	1		1	DDX25	11	125787056	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	23139912	125787056	9219460	42	6164											
ITPR2	3709	broad.mit.edu	37	chr12	26864181	26864181	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactgtcctgcacccccacgGcatgggtcatgatgaaccac	9	16	1	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr12:26864181G>A	uc001rhg.2	-	9	1293	c.876C>T	c.(874-876)TGC>TGT	p.C292C		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	292	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CACCCCCACGGCATGGGTCAT	0.433													A	26864181	A	A	26864181	2	1	92	1	0	0	0	0	0	0	0	1	7921	1195	42	3		3	ITPR2	12	26864181	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08		26864181	106987714	43	6165											
PRPF40B	25766	broad.mit.edu	37	chr12	50028946	50028946	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	acaaggcgcagcgggagaagGaggagaaggaggaggcccgg	21	7	0	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr12:50028946G>C	uc001rur.1	+	12	1064	c.1000G>C	c.(1000-1002)GAG>CAG	p.E334Q	PRPF40B_uc001rup.1_Missense_Mutation_p.E356Q|PRPF40B_uc001ruq.1_Missense_Mutation_p.E328Q|PRPF40B_uc001rus.1_Missense_Mutation_p.E277Q	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	334					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GCGGGAGAAGGAGGAGAAGGA	0.582													C	50028946	C	C	50028946	3	2	92	1	0	0	0	0	1	0	0	0	12572	1175	41	5	1046	5	PRPF40B	12	50028946	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	23164765	50028946	83822949	44	6166											
CAPS2	84698	broad.mit.edu	37	chr12	75692734	75692734	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaatgagctctctgcaagcAtcacgtccattactggaaaa	7	12	2	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr12:75692734A>C	uc001sxk.3	-	11	1121	c.924T>G	c.(922-924)GAT>GAG	p.D308E	CAPS2_uc001sxm.3_Missense_Mutation_p.D76E|CAPS2_uc009zsa.2_Intron|CAPS2_uc001sxi.3_Intron|CAPS2_uc001sxj.3_Intron|CAPS2_uc001sxl.3_Missense_Mutation_p.D289E	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	308							calcium ion binding			ovary(2)	2						CTCTGCAAGCATCACGTCCAT	0.308													C	75692734	C	C	75692734	3	2	92	1	0	0	0	0	1	0	0	0	2638	214	8	5	781	5	CAPS2	12	75692734	Missense_Mutation	SNP	A	TCGA-06-5415-01A-01D-1486-08	25663788	75692734	58159161	45	6167											
NT5DC3	51559	broad.mit.edu	37	chr12	104186945	104186945	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaaataaacactcacctcCgcttatcattaaagaagttt	4	9	2	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr12:104186945C>T	uc010swe.1	-	9	1057	c.1016G>A	c.(1015-1017)CGG>CAG	p.R339Q		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	339							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						CACTCACCTCCGCTTATCATT	0.403													T	104186945	T	T	104186945	3	4	92	1	0	0	0	0	1	0	0	0	10692	652	23	2	654	2	NT5DC3	12	104186945	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08	28494211	104186945	29664950	46	6168											
NOS1	4842	broad.mit.edu	37	chr12	117710315	117710315	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctaggagcatgttggacaCggcggggaggccgtaccact	15	11	1	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr12:117710315C>T	uc001twm.1	-	10	2400	c.1714G>A	c.(1714-1716)GTG>ATG	p.V572M		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	572					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	ATGTTGGACACGGCGGGGAGG	0.617													T	117710315	T	T	117710315	3	4	92	1	0	0	0	0	1	0	0	0	10541	536	19	1	2670	1	NOS1	12	117710315	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08	13523370	117710315	16141580	47	6169											
TMEM132D	121256	broad.mit.edu	37	chr12	130015732	130015732	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcacgccgatgatgttcacGcctttcttcacctttgccct	7	16	3	1	rs147002439		TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr12:130015732G>A	uc009zyl.1	-	3	1315	c.987C>T	c.(985-987)GGC>GGT	p.G329G		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	329	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TGATGTTCACGCCTTTCTTCA	0.557													A	130015732	A	A	130015732	2	1	92	1	0	0	0	0	0	0	0	1	16044	1074	38	1		1	TMEM132D	12	130015732	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08	12305417	130015732	3836163	48	6170											
SERPINA10	51156	broad.mit.edu	37	chr14	94756360	94756360	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgcgaaaattcataggcaCgcactctgtatcaaaatacc	6	10	3	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr14:94756360C>T	uc001yct.2	-	2	1037	c.571G>A	c.(571-573)GTG>ATG	p.V191M	SERPINA10_uc001ycu.3_Missense_Mutation_p.V191M	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	191					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TTCATAGGCACGCACTCTGTA	0.418													T	94756360	T	T	94756360	3	4	92	1	0	0	0	0	1	0	0	0	14087	536	19	1	779	1	SERPINA10	14	94756360	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		94756360	12593180	49	6171											
CILP	8483	broad.mit.edu	37	chr15	65489345	65489345	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatgtgccatcaaagcaccgGccgagcgcgatctccttggc	12	14	2	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr15:65489345G>T	uc002aon.2	-	9	3460	c.3279C>A	c.(3277-3279)GGC>GGA	p.G1093G		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	1093					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CAAAGCACCGGCCGAGCGCGA	0.582													T	65489345	T	T	65489345	2	4	92	1	0	0	0	0	0	0	0	1	3429	1190	42	5		5	CILP	15	65489345	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08		65489345	37042047	50	6172											
SV2B	9899	broad.mit.edu	37	chr15	91835641	91835641	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatggattatgcaaatttggCgccatcctgggaaacaccat	9	9	0	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr15:91835641C>T	uc002bqv.2	+	12	2302	c.1911C>T	c.(1909-1911)GGC>GGT	p.G637G	SV2B_uc010uqv.1_Silent_p.G486G|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	637	Helical; (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GCAAATTTGGCGCCATCCTGG	0.463													T	91835641	T	T	91835641	2	4	92	1	0	0	0	0	0	0	0	1	15415	755	27	1		1	SV2B	15	91835641	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	26346296	91835641	10695751	51	6173											
MSLNL	401827	broad.mit.edu	37	chr16	822701	822701	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caccggagctcctggggatgGatggtctggatctggtgagg	18	8	2	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr16:822701G>A	uc002cjz.1	-	12	2406	c.2406C>T	c.(2404-2406)ATC>ATT	p.I802I		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	451	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						CCTGGGGATGGATGGTCTGGA	0.647													A	822701	A	A	822701	2	1	92	1	0	0	0	0	0	0	0	1	9882	1164	41	3		3	MSLNL	16	822701	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08		822701	89532052	52	6174											
ERCC4	2072	broad.mit.edu	37	chr16	14024621	14024621	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agcttggagccaagactaaaTccttagttcaggatttgaag	10	7	1	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr16:14024621T>A	uc002dce.2	+	5	856	c.847T>A	c.(847-849)TCC>ACC	p.S283T	ERCC4_uc010bva.2_Missense_Mutation_p.S283T	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	283	Leucine-zipper 2.				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						CAAGACTAAATCCTTAGTTCA	0.363			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				A	14024621	A	A	14024621	3	1	92	1	0	0	0	0	1	0	0	0	5215	1435	50	5	865	5	ERCC4	16	14024621	Missense_Mutation	SNP	T	TCGA-06-5415-01A-01D-1486-08	13201920	14024621	76330132	53	6175											
ITPRIPL2	162073	broad.mit.edu	37	chr16	19126333	19126333	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggtgccactgcgcctcccgCcgcttgtggcgctggagcca	14	16	0	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr16:19126333C>G	uc002dfu.3	+	1	1080	c.550C>G	c.(550-552)CCG>GCG	p.P184A	ITPRIPL2_uc002dft.2_5'UTR	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	184	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GCGCCTCCCGCCGCTTGTGGC	0.697											OREG0023657	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	19126333	G	G	19126333	3	3	92	1	0	0	0	0	1	0	0	0	7925	739	26	5	552	5	ITPRIPL2	16	19126333	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08	5101712	19126333	71228420	54	6176											
RANBP10	57610	broad.mit.edu	37	chr16	67763893	67763893	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cagcagccctgggtagaagcGctgggtggtctcgatggcct	16	11	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr16:67763893G>C	uc002eud.2	-	8	1062	c.946C>G	c.(946-948)CGC>GGC	p.R316G	RANBP10_uc010ceo.2_Missense_Mutation_p.R87G|RANBP10_uc010vju.1_Missense_Mutation_p.R260G|RANBP10_uc010vjv.1_Missense_Mutation_p.R199G|RANBP10_uc010vjw.1_5'UTR	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	316	CTLH.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		GGGTAGAAGCGCTGGGTGGTC	0.632													C	67763893	C	C	67763893	3	2	92	1	0	0	0	0	1	0	0	0	13026	1087	38	5	944	5	RANBP10	16	67763893	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	48637560	67763893	22590860	55	6177											
DNAH2	146754	broad.mit.edu	37	chr17	7671485	7671485	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccaacttttgctcaggacCgaaactgggaaattattgaa	8	10	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr17:7671485C>T	uc002giu.1	+	23	3855	c.3841C>T	c.(3841-3843)CGA>TGA	p.R1281*		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1281	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGCTCAGGACCGAAACTGGGA	0.547													T	7671485	T	T	7671485	4	4	92	1	0	0	0	0	0	1	0	0	4602	644	23	2	3931	2	DNAH2	17	7671485	Nonsense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		7671485	73523725	56	6178											
DSG1	1828	broad.mit.edu	37	chr18	28913591	28913591	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgctgtaagaggctctgacCgagatggcggggcagatggc	17	8	1	4			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr18:28913591C>T	uc002kwp.2	+	7	936	c.724C>T	c.(724-726)CGA>TGA	p.R242*		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	242	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AGGCTCTGACCGAGATGGCGG	0.428													T	28913591	T	T	28913591	4	4	92	1	0	0	0	0	0	1	0	0	4776	644	23	2	750	2	DSG1	18	28913591	Nonsense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		28913591	49163657	57	6179											
MUC16	94025	broad.mit.edu	37	chr19	8996490	8996490	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtggctgtcccatccttttcAggcctggagagggcaggtga	15	10	1	2			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:8996490A>G	uc002mkp.2	-	61	41286	c.41082T>C	c.(41080-41082)CCT>CCC	p.P13694P	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.P511P|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13696	Extracellular (Potential).|SEA 11.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CATCCTTTTCAGGCCTGGAGA	0.542													G	8996490	G	G	8996490	2	3	92	1	0	0	0	0	0	0	0	1	9973	175	7	4		4	MUC16	19	8996490	Silent	SNP	A	TCGA-06-5415-01A-01D-1486-08		8996490	50132493	58	6180											
RASAL3	64926	broad.mit.edu	37	chr19	15571922	15571922	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtctccggttctgtttttccAggcatccgatctgtgggtcg	12	11	3	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:15571922A>G	uc002nbe.2	-	5	641	c.555T>C	c.(553-555)CCT>CCC	p.P185P		NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	185					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						CTGTTTTTCCAGGCATCCGAT	0.582													G	15571922	G	G	15571922	2	3	92	1	0	0	0	0	0	0	0	1	13065	175	7	4		4	RASAL3	19	15571922	Silent	SNP	A	TCGA-06-5415-01A-01D-1486-08	6575432	15571922	43557061	59	6181											
ZNF507	22847	broad.mit.edu	37	chr19	32847587	32847609	+	Frame_Shift_Del	DEL	TAATGAGCCAAGAATTTCCAGTG	-	-													accttgtcaatagcaacttcTaatgagccaagaatttccag							TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:32847587_32847609delTAATGAGCCAAGAATTTCCAGTG	uc002nte.2	+	4	2465_2487	c.2193_2215delTAATGAGCCAAGAATTTCCAGTG	c.(2191-2217)TCTAATGAGCCAAGAATTTCCAGTGATfs	p.S731fs	ZNF507_uc002ntc.2_Frame_Shift_Del_p.S731fs|ZNF507_uc010xrn.1_Frame_Shift_Del_p.S731fs|ZNF507_uc002ntd.2_Frame_Shift_Del_p.S731fs	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	731_739					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					TAGCAACTTCTAATGAGCCAAGAATTTCCAGTGATACAGCTGA	0.381													-	32847609	-	-	32847587	7	5	92	1	0	1	0	1	0	0	0	0	17950	1509	53	0	2199	0	ZNF507	19	32847587	Frame_Shift_Del	DEL	TAATGAGCCAAGAATTTCCAGTG	TCGA-06-5415-01A-01D-1486-08	17275665	32847587	26281396	60	6182											
OPA3	80207	broad.mit.edu	37	chr19	46056784	46056784	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaagctcctatttcttggaCgcaggcactgcgtgggaagc	13	11	1	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:46056784C>T	uc002pck.3	-	2	628	c.528G>A	c.(526-528)GCG>GCA	p.A176A	OPA3_uc002pcj.3_Intron|OPA3_uc010xxk.1_Silent_p.A123A	NM_025136	NP_079412	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform b	176					response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		ATTTCTTGGACGCAGGCACTG	0.637													T	46056784	T	T	46056784	2	4	92	1	0	0	0	0	0	0	0	1	10872	523	19	1		1	OPA3	19	46056784	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	13209197	46056784	13072199	61	6183											
CCDC114	93233	broad.mit.edu	37	chr19	48805978	48805978	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcttctccagctgtccccGcacatcctggaagcgggcct	11	16	1	0			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:48805978G>A	uc002pir.2	-	10	1785	c.1102C>T	c.(1102-1104)CGG>TGG	p.R368W	CCDC114_uc002piq.2_Missense_Mutation_p.R177W|CCDC114_uc002pio.2_Missense_Mutation_p.R405W|CCDC114_uc002pis.1_Missense_Mutation_p.R48W|CCDC114_uc002pit.1_Missense_Mutation_p.R405W	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	368	Potential.									ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		AGCTGTCCCCGCACATCCTGG	0.647													A	48805978	A	A	48805978	3	1	92	1	0	0	0	0	1	0	0	0	2751	1086	38	1	930	1	CCDC114	19	48805978	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	2749194	48805978	10323005	62	6184											
CA11	770	broad.mit.edu	37	chr19	49143426	49143426	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agctccaaacagcagccgcaGttcactgagtcggtggctgt	12	12	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:49143426G>C	uc002pjz.1	-	4	959	c.397C>G	c.(397-399)CTG>GTG	p.L133V	SEC1_uc010xzv.1_Intron|SEC1_uc002pka.2_Intron|SEC1_uc010xzw.1_Intron|SEC1_uc010ema.2_Intron|DBP_uc002pjx.3_5'Flank|DBP_uc002pjy.2_5'Flank|DBP_uc010elz.1_5'Flank	NM_001217	NP_001208	O75493	CAH11_HUMAN	carbonic anhydrase XI precursor	133						extracellular region					0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000103)|all cancers(93;0.000119)|GBM - Glioblastoma multiforme(486;0.00634)|Epithelial(262;0.016)		AGCAGCCGCAGTTCACTGAGT	0.592													C	49143426	C	C	49143426	3	2	92	1	0	0	0	0	1	0	0	0	2512	1020	36	5	613	5	CA11	19	49143426	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	337448	49143426	9985557	63	6185											
SIGLEC10	89790	broad.mit.edu	37	chr19	51919569	51919569	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacggccctcagtacctggcGtgttgtcacgtgaaatgctg	13	11	2	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:51919569G>A	uc002pwo.2	-	4	1365	c.749C>T	c.(748-750)ACG>ATG	p.T250M	SIGLEC10_uc002pwp.2_Missense_Mutation_p.T192M|SIGLEC10_uc002pwq.2_Missense_Mutation_p.T192M|SIGLEC10_uc002pwr.2_Missense_Mutation_p.T250M|SIGLEC10_uc010ycy.1_Missense_Mutation_p.T250M|SIGLEC10_uc010ycz.1_Missense_Mutation_p.T202M|SIGLEC10_uc010eow.2_Missense_Mutation_p.R15C|SIGLEC10_uc002pws.1_Missense_Mutation_p.T176M	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	250	Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AGTACCTGGCGTGTTGTCACG	0.483													A	51919569	A	A	51919569	3	1	92	1	0	0	0	0	1	0	0	0	14306	1145	40	1	1376	1	SIGLEC10	19	51919569	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	2776143	51919569	7209414	64	6186											
LILRB4	11006	broad.mit.edu	37	chr19	55175317	55175317	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggaggctcgggagtaccGtctggataaagaggaaagcc	15	9	1	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:55175317G>A	uc002qgp.2	+	3	538	c.176G>A	c.(175-177)CGT>CAT	p.R59H	LILRB4_uc002qgo.1_Missense_Mutation_p.R100H|LILRB4_uc002qgq.2_Missense_Mutation_p.R59H|LILRB4_uc010ers.1_5'UTR|LILRB4_uc002qgr.2_Missense_Mutation_p.R100H|LILRB4_uc010ert.2_Missense_Mutation_p.R100H|LILRB4_uc010eru.2_Missense_Mutation_p.R88H	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	59	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		CGGGAGTACCGTCTGGATAAA	0.587													A	55175317	A	A	55175317	3	1	92	1	0	0	0	0	1	0	0	0	8793	1145	40	1	186	1	LILRB4	19	55175317	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	3255748	55175317	3953666	65	6187											
NLRP7	199713	broad.mit.edu	37	chr19	55450816	55450816	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagcagcctttggagactctGtcctggcggaggatgtctcc	13	11	2	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:55450816G>A	uc002qih.3	-	4	1447	c.1371C>T	c.(1369-1371)GAC>GAT	p.D457D	NLRP7_uc002qig.3_Silent_p.D457D|NLRP7_uc002qii.3_Silent_p.D457D|NLRP7_uc010esk.2_Silent_p.D457D|NLRP7_uc010esl.2_Silent_p.D485D	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	457	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TGGAGACTCTGTCCTGGCGGA	0.617													A	55450816	A	A	55450816	2	1	92	1	0	0	0	0	0	0	0	1	10482	1368	48	3		3	NLRP7	19	55450816	Silent	SNP	G	TCGA-06-5415-01A-01D-1486-08	275499	55450816	3678167	66	6188											
PTPRH	5794	broad.mit.edu	37	chr19	55708508	55708508	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggacgcacagaggctctgcGtggaactggctacgtcattc	13	11	2	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr19:55708508G>A	uc002qjq.2	-	9	2040	c.1967C>T	c.(1966-1968)ACG>ATG	p.T656M	PTPRH_uc010esv.2_Missense_Mutation_p.T478M|PTPRH_uc002qjs.2_Missense_Mutation_p.T663M	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	656	Extracellular (Potential).|Fibronectin type-III 7.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GAGGCTCTGCGTGGAACTGGC	0.547													A	55708508	A	A	55708508	3	1	92	1	0	0	0	0	1	0	0	0	12803	1145	40	1	1428	1	PTPRH	19	55708508	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	257692	55708508	3420475	67	6189											
PCSK2	5126	broad.mit.edu	37	chr20	17445987	17445987	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcctgggtctgacctggCgggacatgcagcatctgact	13	13	2	2	rs138900084		TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr20:17445987C>T	uc002wpm.2	+	11	1539	c.1219C>T	c.(1219-1221)CGG>TGG	p.R407W	PCSK2_uc002wpl.2_Missense_Mutation_p.R388W|PCSK2_uc010zrm.1_Missense_Mutation_p.R372W|PCSK2_uc002wpn.2_Missense_Mutation_p.R61W	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	407	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTGACCTGGCGGGACATGCA	0.552													T	17445987	T	T	17445987	3	4	92	1	0	0	0	0	1	0	0	0	11601	759	27	1	1261	1	PCSK2	20	17445987	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		17445987	45579533	68	6190											
TPX2	22974	broad.mit.edu	37	chr20	30371716	30371716	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gccctactaagattttggaaGatgttgtggtaaggttgagg	14	4	0	3			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr20:30371716G>T	uc002wwp.1	+	12	2103	c.1405G>T	c.(1405-1407)GAT>TAT	p.D469Y	TPX2_uc010gdv.1_Missense_Mutation_p.D505Y	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	469					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GATTTTGGAAGATGTTGTGGT	0.333													T	30371716	T	T	30371716	3	4	92	1	0	0	0	0	1	0	0	0	16429	942	33	5	1443	5	TPX2	20	30371716	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	12925729	30371716	32653804	69	6191											
BPI	671	broad.mit.edu	37	chr20	36932646	36932646	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggccaggggcccttgcaaCgcgccgagatgggcgtccct	15	14	0	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr20:36932646C>T	uc002xib.2	+	1	95	c.33C>T	c.(31-33)AAC>AAT	p.N11N		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	11					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				GCCCTTGCAACGCGCCGAGAT	0.627													T	36932646	T	T	36932646	2	4	92	1	0	0	0	0	0	0	0	1	1490	535	19	1		1	BPI	20	36932646	Silent	SNP	C	TCGA-06-5415-01A-01D-1486-08	6560930	36932646	26092874	70	6192											
KRTAP10-9	386676	broad.mit.edu	37	chr21	46047200	46047200	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcgccaccagctgctgcGccccggccccctgcctgacc	11	22	0	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr21:46047200G>A	uc002zfp.3	+	1	161	c.112G>A	c.(112-114)GCC>ACC	p.A38T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	38	3.|25 X 5 AA repeats of C-C-X(3).					keratin filament					0						CAGCTGCTGCGCCCCGGCCCC	0.687													A	46047200	A	A	46047200	3	1	92	1	0	0	0	0	1	0	0	0	8516	1087	38	1	114	1	KRTAP10-9	21	46047200	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08		46047200	2082695	71	6193											
KRTAP10-11	386678	broad.mit.edu	37	chr21	46066382	46066382	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccccaccccagcatggccGcgtccaccatgtctgtctgc	8	20	2	0	rs150246805	by1000genomes	TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr21:46066382G>A	uc002zfr.3	+	1	52	c.7G>A	c.(7-9)GCG>ACG	p.A3T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	3						keratin filament				ovary(1)	1						CAGCATGGCCGCGTCCACCAT	0.542													A	46066382	A	A	46066382	3	1	92	1	0	0	0	0	1	0	0	0	8507	1087	38	1	9	1	KRTAP10-11	21	46066382	Missense_Mutation	SNP	G	TCGA-06-5415-01A-01D-1486-08	19182	46066382	2063513	72	6194											
TMPRSS6	164656	broad.mit.edu	37	chr22	37491997	37491997	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtactcggccctgtaggggaCggcagccgagctgttgactg	16	11	0	1			TCGA-06-5415-01A-01D-1486-08	TCGA-06-5415-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	fca08ee9-b480-4dc7-be56-f1eb03b56f7c	e09e94f5-bd10-4523-bc83-d441a285c37c	g.chr22:37491997C>T	uc003aqs.1	-	5	679	c.565G>A	c.(565-567)GTC>ATC	p.V189I	TMPRSS6_uc003aqt.1_Missense_Mutation_p.V180I|TMPRSS6_uc003aqu.2_Missense_Mutation_p.V180I	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	189	Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						CTGTAGGGGACGGCAGCCGAG	0.642													T	37491997	T	T	37491997	3	4	92	1	0	0	0	0	1	0	0	0	16248	536	19	1	1926	1	TMPRSS6	22	37491997	Missense_Mutation	SNP	C	TCGA-06-5415-01A-01D-1486-08		37491997	13812569	73	6195											
HSPG2	3339	broad.mit.edu	37	chr1	22154901	22154901	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgtaggtgaggtccagccGtttgccattcactgacacct	10	12	1	2	rs146179360	byFrequency	TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr1:22154901G>A	uc001bfj.2	-	89	12296	c.12256C>T	c.(12256-12258)CGG>TGG	p.R4086W	HSPG2_uc001bfi.2_Missense_Mutation_p.R103W|HSPG2_uc009vqd.2_Missense_Mutation_p.R4087W	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	4086	Laminin G-like 2.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGGTCCAGCCGTTTGCCATTC	0.597													A	22154901	A	A	22154901	3	1	93	1	0	0	0	0	1	0	0	0	7430	1144	40	1	955	1	HSPG2	1	22154901	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08		22154901	227095720	1	6196											
GRHL3	57822	broad.mit.edu	37	chr1	24661135	24661135	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttcctttctctcttctcagGgtcccaaggagaagcggata	9	12	3	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr1:24661135G>T	uc001biy.2	+	3	266	c.220G>T	c.(220-222)GGT>TGT	p.G74C	GRHL3_uc001bix.2_Missense_Mutation_p.G69C|GRHL3_uc001biz.2_5'UTR	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	69	Transcription activation.				regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CTCTTCTCAGGGTCCCAAGGA	0.552													T	24661135	T	T	24661135	3	4	93	1	0	0	0	0	1	0	0	0	6765	1246	43	5	251	5	GRHL3	1	24661135	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	2506234	24661135	224589486	2	6197											
FAM73A	374986	broad.mit.edu	37	chr1	78338781	78338781	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttgggtcctagaaattctctGtatgatttatgttgcttttt	8	5	1	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr1:78338781G>C	uc001dhx.2	+	15	1688	c.1656G>C	c.(1654-1656)CTG>CTC	p.L552L	FAM73A_uc010ork.1_Silent_p.L553L|FAM73A_uc010orl.1_Silent_p.L515L	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	552						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		GAAATTCTCTGTATGATTTAT	0.358													C	78338781	C	C	78338781	2	2	93	1	0	0	0	0	0	0	0	1	5617	1364	48	5		5	FAM73A	1	78338781	Silent	SNP	G	TCGA-06-5417-01A-01D-1486-08	53677646	78338781	170911840	3	6198											
TTLL7	79739	broad.mit.edu	37	chr1	84408356	84408356	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcaccatttcttatcaaAgaaatcctatgtttaaagaa	4	7	3	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr1:84408356A>T	uc001djc.2	-	7	909	c.513T>A	c.(511-513)TCT>TCA	p.S171S	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_Intron|TTLL7_uc001djf.2_Intron|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	171	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TTCTTATCAAAGAAATCCTAT	0.269													T	84408356	T	T	84408356	2	4	93	1	0	0	0	0	0	0	0	1	16729	59	3	5		5	TTLL7	1	84408356	Silent	SNP	A	TCGA-06-5417-01A-01D-1486-08	6069575	84408356	164842265	4	6199											
KCNA10	3744	broad.mit.edu	37	chr1	111060530	111060530	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagaagtcagtcttgctggGgcagaccacgaaccggagca	14	10	2	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr1:111060530G>A	uc001dzt.1	-	1	1268	c.880C>T	c.(880-882)CCC>TCC	p.P294S		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	294						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GTCTTGCTGGGGCAGACCACG	0.512													A	111060530	A	A	111060530	3	1	93	1	0	0	0	0	1	0	0	0	8002	1232	43	3	659	3	KCNA10	1	111060530	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	26652174	111060530	138190091	5	6200											
FLG2	388698	broad.mit.edu	37	chr1	152326101	152326101	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtccataagtagtttcatgTctctcatgaactgtggattc	8	8	3	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr1:152326101T>C	uc001ezw.3	-	3	4234	c.4161A>G	c.(4159-4161)AGA>AGG	p.R1387R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1387							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGTTTCATGTCTCTCATGAA	0.507													C	152326101	C	C	152326101	2	2	93	1	0	0	0	0	0	0	0	1	5923	1664	58	4		4	FLG2	1	152326101	Silent	SNP	T	TCGA-06-5417-01A-01D-1486-08	41265571	152326101	96924520	6	6201											
RNPEP	6051	broad.mit.edu	37	chr1	201966632	201966632	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctggggtgaattctggctcaAtgaaggtttcaccatgtacg	12	8	3	2	rs114130028		TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr1:201966632A>T	uc001gxd.2	+	5	1069	c.1040A>T	c.(1039-1041)AAT>ATT	p.N347I	RNPEP_uc001gxe.2_Missense_Mutation_p.N48I|RNPEP_uc001gxf.2_Missense_Mutation_p.N216I	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase	347					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		TTCTGGCTCAATGAAGGTTTC	0.542													T	201966632	T	T	201966632	3	4	93	1	0	0	0	0	1	0	0	0	13509	101	4	5	1058	5	RNPEP	1	201966632	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08	49640531	201966632	47283989	7	6202											
RPS6KC1	26750	broad.mit.edu	37	chr1	213414537	213414537	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agctcacgagctgaagttctTccccaacgatgacccagaag	9	13	2	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr1:213414537T>C	uc010ptr.1	+	11	1877	c.1718T>C	c.(1717-1719)TTC>TCC	p.F573S	RPS6KC1_uc001hkd.2_Missense_Mutation_p.F561S|RPS6KC1_uc010pts.1_Missense_Mutation_p.F361S|RPS6KC1_uc010ptt.1_Missense_Mutation_p.F361S|RPS6KC1_uc010ptu.1_Missense_Mutation_p.F392S|RPS6KC1_uc010ptv.1_Missense_Mutation_p.F108S|RPS6KC1_uc001hke.2_Missense_Mutation_p.F392S	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	573					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CTGAAGTTCTTCCCCAACGAT	0.458													C	213414537	C	C	213414537	3	2	93	1	0	0	0	0	1	0	0	0	13658	1783	62	4	1760	4	RPS6KC1	1	213414537	Missense_Mutation	SNP	T	TCGA-06-5417-01A-01D-1486-08	11447905	213414537	35836084	8	6203											
EPAS1	2034	broad.mit.edu	37	chr2	46603736	46603736	+	Frame_Shift_Del	DEL	C	-	-													agactgaatccctgttcaagCcccacctgatggccatgaac							TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr2:46603736delC	uc002ruv.2	+	9	1581	c.1093delC	c.(1093-1095)CCCfs	p.P365fs		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	365					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CCTGTTCAAGCCCCACCTGAT	0.493													-	46603736	-	-	46603736	7	5	93	1	0	1	0	1	0	0	0	0	5150	739	26	0	1127	0	EPAS1	2	46603736	Frame_Shift_Del	DEL	C	TCGA-06-5417-01A-01D-1486-08		46603736	196595637	9	6204											
SPTBN1	6711	broad.mit.edu	37	chr2	54856159	54856159	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgccagctggcggctgagCgcagggcccgtctggaagag	17	11	1	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr2:54856159C>T	uc002rxu.2	+	14	2137	c.1888C>T	c.(1888-1890)CGC>TGC	p.R630C	SPTBN1_uc002rxv.1_Missense_Mutation_p.R630C|SPTBN1_uc002rxx.2_Missense_Mutation_p.R617C	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	630	Spectrin 4.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GGCGGCTGAGCGCAGGGCCCG	0.582													T	54856159	T	T	54856159	3	4	93	1	0	0	0	0	1	0	0	0	15118	768	27	1	2051	1	SPTBN1	2	54856159	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08	8252423	54856159	188343214	10	6205											
GALNT13	114805	broad.mit.edu	37	chr2	155099286	155099286	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aattattaggatggaagaacGctctgggttaatacgtgccc	11	7	1	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr2:155099286G>A	uc002tyr.3	+	6	1121	c.554G>A	c.(553-555)CGC>CAC	p.R185H	GALNT13_uc002tyt.3_Missense_Mutation_p.R185H|GALNT13_uc010foc.1_Missense_Mutation_p.R4H	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	185	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						ATGGAAGAACGCTCTGGGTTA	0.388													A	155099286	A	A	155099286	3	1	93	1	0	0	0	0	1	0	0	0	6211	1087	38	1	568	1	GALNT13	2	155099286	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	100243127	155099286	88100087	11	6206											
MDH1B	130752	broad.mit.edu	37	chr2	207615789	207615789	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atattaccccaaatgatcacGtctttaatgtctgtgaagaa	6	8	3	3	rs146327472	byFrequency	TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr2:207615789G>A	uc002vbs.2	-	6	976	c.921C>T	c.(919-921)GAC>GAT	p.D307D	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Silent_p.D307D|MDH1B_uc010fuj.2_Silent_p.D209D|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	307					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		AAATGATCACGTCTTTAATGT	0.308													A	207615789	A	A	207615789	2	1	93	1	0	0	0	0	0	0	0	1	9409	1136	40	1		1	MDH1B	2	207615789	Silent	SNP	G	TCGA-06-5417-01A-01D-1486-08	52516503	207615789	35583584	12	6207											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	93	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08	1497323	209113112	34086261	13	6208											
ROBO1	6091	broad.mit.edu	37	chr3	78656067	78656070	+	Frame_Shift_Del	DEL	TCTG	-	-													cttccttttctgtctgatgaTctgtctgttcttgcatccat							TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr3:78656067_78656070delTCTG	uc003dqe.2	-	29	4765_4768	c.4557_4560delCAGA	c.(4555-4560)GACAGAfs	p.D1519fs	ROBO1_uc003dqb.2_Frame_Shift_Del_p.D1480fs|ROBO1_uc003dqc.2_Frame_Shift_Del_p.D1419fs|ROBO1_uc003dqd.2_Frame_Shift_Del_p.D1474fs|ROBO1_uc010hoh.2_Frame_Shift_Del_p.D711fs|ROBO1_uc011bgl.1_Frame_Shift_Del_p.D1091fs	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1519_1520	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TGTCTGATGATCTGTCTGTTCTTG	0.485													-	78656070	-	-	78656067	7	5	93	1	0	1	0	1	0	0	0	0	13513	1432	50	0	407	0	ROBO1	3	78656067	Frame_Shift_Del	DEL	TCTG	TCGA-06-5417-01A-01D-1486-08		78656067	119366363	14	6209											
POLQ	10721	broad.mit.edu	37	chr3	121230744	121230744	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tctctcttacctccagaataGctcgtatcatgctgccagtt	6	13	3	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr3:121230744G>C	uc003eee.3	-	10	1730	c.1601C>G	c.(1600-1602)GCT>GGT	p.A534G		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	534	Helicase C-terminal.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CTCCAGAATAGCTCGTATCAT	0.358								DNA_polymerases_(catalytic_subunits)					C	121230744	C	C	121230744	3	2	93	1	0	0	0	0	1	0	0	0	12208	971	34	5	6255	5	POLQ	3	121230744	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	42574677	121230744	76791686	15	6210											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178936091	A	A	178936091	3	1	93	1	0	0	0	0	1	0	0	0	11913	1291	45	3	1667	3	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	57705347	178936091	19086339	16	6211											
EIF4G1	1981	broad.mit.edu	37	chr3	184052651	184052651	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cttaaatctgtcacagccttCttcaagtggctccgtgaagc	8	12	4	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr3:184052651C>G	uc003fnp.2	+	33	4953	c.4755C>G	c.(4753-4755)TTC>TTG	p.F1585L	EIF4G1_uc003fnt.2_Missense_Mutation_p.F1296L|EIF4G1_uc003fnq.2_Missense_Mutation_p.F1498L|EIF4G1_uc003fnr.2_Missense_Mutation_p.F1421L|EIF4G1_uc010hxx.2_Missense_Mutation_p.F1592L|EIF4G1_uc003fns.2_Missense_Mutation_p.F1545L|EIF4G1_uc010hxy.2_Missense_Mutation_p.F1592L|EIF4G1_uc003fnv.3_Missense_Mutation_p.F1586L|EIF4G1_uc003fnu.3_Missense_Mutation_p.F1585L|EIF4G1_uc003fnw.2_Missense_Mutation_p.F1592L|EIF4G1_uc003fny.3_Missense_Mutation_p.F1389L|EIF4G1_uc003foa.2_Missense_Mutation_p.F257L|FAM131A_uc003fob.1_5'Flank|FAM131A_uc003foc.2_5'Flank|FAM131A_uc003fod.1_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1585	W2.|Necessary but not sufficient for MKNK1- binding.|EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCACAGCCTTCTTCAAGTGGC	0.607													G	184052651	G	G	184052651	3	3	93	1	0	0	0	0	1	0	0	0	5036	912	32	5	4877	5	EIF4G1	3	184052651	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08	5116560	184052651	13969779	17	6212											
SEL1L3	23231	broad.mit.edu	37	chr4	25819779	25819779	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggtcagcagatccatctcCagcaatgcctggaacaagct	9	14	2	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr4:25819779C>T	uc003gru.3	-	9	1697	c.1545G>A	c.(1543-1545)CTG>CTA	p.L515L		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	515						integral to membrane	binding				0						GATCCATCTCCAGCAATGCCT	0.537													T	25819779	T	T	25819779	2	4	93	1	0	0	0	0	0	0	0	1	14012	581	21	3		3	SEL1L3	4	25819779	Silent	SNP	C	TCGA-06-5417-01A-01D-1486-08		25819779	165334497	18	6213											
WDR19	57728	broad.mit.edu	37	chr4	39218764	39218764	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	attgctacagctgtgaaaaaAttgaaagatatggagtatct	9	4	1	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr4:39218764A>T	uc003gtv.2	+	13	1414	c.1260A>T	c.(1258-1260)AAA>AAT	p.K420N	WDR19_uc003gtu.1_Missense_Mutation_p.K420N|WDR19_uc011byi.1_Missense_Mutation_p.K260N|WDR19_uc003gtw.1_Missense_Mutation_p.K17N	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	420					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						CTGTGAAAAAATTGAAAGATA	0.343													T	39218764	T	T	39218764	3	4	93	1	0	0	0	0	1	0	0	0	17276	98	4	5	1310	5	WDR19	4	39218764	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08	13398985	39218764	151935512	19	6214											
ZAR1	326340	broad.mit.edu	37	chr4	48494815	48494815	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaatatggctattaccactgCaaggactgcaacatccgctg	8	11	0	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr4:48494815C>G	uc003gyd.2	+	2	996	c.996C>G	c.(994-996)TGC>TGG	p.C332W		NM_175619	NP_783318	Q86SH2	ZAR1_HUMAN	zygote arrest 1	332					multicellular organismal development	cytoplasm|membrane	bile acid:sodium symporter activity				0						ATTACCACTGCAAGGACTGCA	0.418													G	48494815	G	G	48494815	3	3	93	1	0	0	0	0	1	0	0	0	17512	718	25	5	1002	5	ZAR1	4	48494815	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08	9276051	48494815	142659461	20	6215											
POLR2B	5431	broad.mit.edu	37	chr4	57890238	57890238	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccccatgccatcccctctcGtatgactattggtcacttaa	5	15	2	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr4:57890238G>A	uc003hcl.1	+	21	2967	c.2924G>A	c.(2923-2925)CGT>CAT	p.R975H	POLR2B_uc011cae.1_Missense_Mutation_p.R968H|POLR2B_uc011caf.1_Missense_Mutation_p.R900H|POLR2B_uc003hcm.1_Missense_Mutation_p.R468H	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	975					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					ATCCCCTCTCGTATGACTATT	0.378													A	57890238	A	A	57890238	3	1	93	1	0	0	0	0	1	0	0	0	12215	1145	40	1	3006	1	POLR2B	4	57890238	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	9395423	57890238	133264038	21	6216											
WWC2	80014	broad.mit.edu	37	chr4	184210574	184210574	+	Frame_Shift_Del	DEL	C	-	-													ccagtcagtccttagaagaaCaacacaggaatgcccagtgc							TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr4:184210574delC	uc010irx.2	+	21	3352	c.3170delC	c.(3169-3171)ACAfs	p.T1057fs	WWC2_uc003ivk.3_Frame_Shift_Del_p.T852fs|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Frame_Shift_Del_p.T739fs|WWC2_uc003ivn.3_Frame_Shift_Del_p.T572fs|WWC2_uc010irz.2_Frame_Shift_Del_p.T398fs|WWC2_uc003ivo.3_Frame_Shift_Del_p.T185fs	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1057										ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		CTTAGAAGAACAACACAGGAA	0.498													-	184210574	-	-	184210574	7	5	93	1	0	1	0	1	0	0	0	0	17409	478	17	0	3252	0	WWC2	4	184210574	Frame_Shift_Del	DEL	C	TCGA-06-5417-01A-01D-1486-08	126320336	184210574	6943702	22	6217											
MARCH6	10299	broad.mit.edu	37	chr5	10387160	10387160	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gagctcactactgacgctgcCattagatatgctgtcaacgt	9	11	2	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr5:10387160C>G	uc003jet.1	+	5	572	c.389C>G	c.(388-390)CCA>CGA	p.P130R	MARCH6_uc011cmu.1_Missense_Mutation_p.P82R|MARCH6_uc003jeu.1_5'UTR|MARCH6_uc011cmv.1_Missense_Mutation_p.P25R	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	130	Extracellular (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						CTGACGCTGCCATTAGATATG	0.423													G	10387160	G	G	10387160	3	3	93	1	0	0	0	0	1	0	0	0	9305	594	21	5	407	5	MARCH6	5	10387160	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08		10387160	170528100	23	6218											
ACOT12	134526	broad.mit.edu	37	chr5	80643615	80643615	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcagaaatagtagccactgTctccatccacgccataatct	6	13	2	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr5:80643615T>C	uc003khl.3	-	6	686	c.631A>G	c.(631-633)ACA>GCA	p.T211A	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	211	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		GTAGCCACTGTCTCCATCCAC	0.498													C	80643615	C	C	80643615	3	2	93	1	0	0	0	0	1	0	0	0	150	1667	58	4	1076	4	ACOT12	5	80643615	Missense_Mutation	SNP	T	TCGA-06-5417-01A-01D-1486-08	70256455	80643615	100271645	24	6219											
STARD4	134429	broad.mit.edu	37	chr5	110842033	110842033	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaaaagttacttacagataTccattaaattcttctgaggg	6	6	2	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr5:110842033T>G	uc003kph.1	-	3	234	c.150A>C	c.(148-150)GGA>GGC	p.G50G	STARD4_uc010jbw.1_5'UTR|STARD4_uc010jbx.1_5'UTR|STARD4_uc003kpi.1_RNA|STARD4_uc003kpj.2_Silent_p.G50G	NM_139164	NP_631903	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain	50	START.				lipid transport		lipid binding			ovary(1)	1		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		CTTACAGATATCCATTAAATT	0.303													G	110842033	G	G	110842033	2	3	93	1	0	0	0	0	0	0	0	1	15258	1422	50	5		5	STARD4	5	110842033	Silent	SNP	T	TCGA-06-5417-01A-01D-1486-08	30198418	110842033	70073227	25	6220											
SOX4	6659	broad.mit.edu	37	chr6	21595085	21595085	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaagacagcgacaagatccCtttcattcgagaggcggagc	11	11	1	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr6:21595085C>T	uc003ndi.2	+	1	1114	c.320C>T	c.(319-321)CCT>CTT	p.P107L		NM_003107	NP_003098	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	107	HMG box.				canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity				0	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			GACAAGATCCCTTTCATTCGA	0.602													T	21595085	T	T	21595085	3	4	93	1	0	0	0	0	1	0	0	0	14953	681	24	3	322	3	SOX4	6	21595085	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08		21595085	149519982	26	6221											
VARS2	57176	broad.mit.edu	37	chr6	30893483	30893483	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagtgacacggctcaagtctAcatggagctgcaggtgacca	12	11	2	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr6:30893483A>G	uc003nsc.1	+	27	3580	c.2948A>G	c.(2947-2949)TAC>TGC	p.Y983C	VARS2_uc011dmx.1_Missense_Mutation_p.Y983C|VARS2_uc011dmy.1_Missense_Mutation_p.Y843C|VARS2_uc011dmz.1_Missense_Mutation_p.Y1013C|VARS2_uc011dna.1_Missense_Mutation_p.Y981C|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_Missense_Mutation_p.Y421C|VARS2_uc010jsg.1_Missense_Mutation_p.Y355C|VARS2_uc010jsh.1_Missense_Mutation_p.Y127C	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	983					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						GCTCAAGTCTACATGGAGCTG	0.647													G	30893483	G	G	30893483	3	3	93	1	0	0	0	0	1	0	0	0	17121	391	14	4	3148	4	VARS2	6	30893483	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08	9298398	30893483	140221584	27	6222											
PHF1	5252	broad.mit.edu	37	chr6	33382595	33382595	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagccccctactggagatggAgcactcaccaggtcactggt	12	13	2	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr6:33382595A>G	uc003oeh.2	+	11	1274	c.1038A>G	c.(1036-1038)GGA>GGG	p.G346G	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Silent_p.G346G|PHF1_uc010jux.2_Silent_p.G146G	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	346					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				CTGGAGATGGAGCACTCACCA	0.552											OREG0017346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	33382595	G	G	33382595	2	3	93	1	0	0	0	0	0	0	0	1	11820	291	11	4		4	PHF1	6	33382595	Silent	SNP	A	TCGA-06-5417-01A-01D-1486-08	2489112	33382595	137732472	28	6223											
LMBRD1	55788	broad.mit.edu	37	chr6	70411840	70411840	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aagatgaaaaatattccccaGacgatctaaaagcaaaaata	5	7	1	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr6:70411840G>C	uc003pfa.2	-	10	1036	c.921C>G	c.(919-921)GTC>GTG	p.V307V	LMBRD1_uc003pey.2_Silent_p.V103V|LMBRD1_uc003pez.2_Silent_p.V234V|LMBRD1_uc010kal.2_Silent_p.V234V|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	307	Helical; Name=6; (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						ATATTCCCCAGACGATCTAAA	0.269													C	70411840	C	C	70411840	2	2	93	1	0	0	0	0	0	0	0	1	8842	929	33	5		5	LMBRD1	6	70411840	Silent	SNP	G	TCGA-06-5417-01A-01D-1486-08	37029245	70411840	100703227	29	6224											
SYNE1	23345	broad.mit.edu	37	chr6	152737569	152737569	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctttcaatcgctctttgtcAgtcctttcttcaatgtcctc	4	13	6	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr6:152737569A>G	uc010kiw.2	-	41	6605	c.6003T>C	c.(6001-6003)ACT>ACC	p.T2001T	SYNE1_uc003qot.3_Silent_p.T2008T|SYNE1_uc003qou.3_Silent_p.T2001T|SYNE1_uc010kjb.1_Silent_p.T1984T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2001	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCTCTTTGTCAGTCCTTTCTT	0.448										HNSCC(10;0.0054)			G	152737569	G	G	152737569	2	3	93	1	0	0	0	0	0	0	0	1	15442	175	7	4		4	SYNE1	6	152737569	Silent	SNP	A	TCGA-06-5417-01A-01D-1486-08	82325729	152737569	18377498	30	6225											
CTTNBP2	83992	broad.mit.edu	37	chr7	117431218	117431218	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggctgtctgaggcacctgGtctacaggatgaggcactaa	14	9	2	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr7:117431218G>A	uc003vjf.2	-	4	2124	c.2032C>T	c.(2032-2034)CCA>TCA	p.P678S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	678										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GAGGCACCTGGTCTACAGGAT	0.468													A	117431218	A	A	117431218	3	1	93	1	0	0	0	0	1	0	0	0	4045	1261	44	3	3039	3	CTTNBP2	7	117431218	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08		117431218	41707445	31	6226											
XKR9	389668	broad.mit.edu	37	chr8	71593354	71593354	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gcattataatctacgtaactGatttaattgtggacatatgg	8	5	1	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr8:71593354G>T	uc003xyq.2	+	3	595	c.61G>T	c.(61-63)GAT>TAT	p.D21Y	XKR9_uc010lze.2_Missense_Mutation_p.D21Y|XKR9_uc010lzd.2_5'UTR	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	21	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			CTACGTAACTGATTTAATTGT	0.318													T	71593354	T	T	71593354	3	4	93	1	0	0	0	0	1	0	0	0	17435	1290	45	5	63	5	XKR9	8	71593354	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08		71593354	74770668	32	6227											
EFR3A	23167	broad.mit.edu	37	chr8	132966108	132966108	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtattcaaggtgtggttcgcAaaacagtcaacgatgaactt	10	7	2	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr8:132966108A>G	uc003yte.2	+	6	733	c.532A>G	c.(532-534)AAA>GAA	p.K178E		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	178						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TGTGGTTCGCAAAACAGTCAA	0.353													G	132966108	G	G	132966108	3	3	93	1	0	0	0	0	1	0	0	0	4958	131	5	4	554	4	EFR3A	8	132966108	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08	61372754	132966108	13397914	33	6228											
FBXO10	26267	broad.mit.edu	37	chr9	37522884	37522884	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccacaaccacaccatctgaaTagccaaagcagatgaggtta	7	12	1	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr9:37522884T>C	uc004aab.2	-	7	1917	c.1868A>G	c.(1867-1869)TAT>TGT	p.Y623C	FBXO10_uc004aac.2_Missense_Mutation_p.Y639C|FBXO10_uc004aad.2_Missense_Mutation_p.Y173C	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	623	PbH1 10.					ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		ACCATCTGAATAGCCAAAGCA	0.468													C	37522884	C	C	37522884	3	2	93	1	0	0	0	0	1	0	0	0	5726	1406	49	4	1022	4	FBXO10	9	37522884	Missense_Mutation	SNP	T	TCGA-06-5417-01A-01D-1486-08		37522884	103690547	34	6229											
OR13C8	138802	broad.mit.edu	37	chr9	107332296	107332296	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaggccctcatctccctttTctatggagtgatgactccca	8	13	3	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr9:107332296T>C	uc011lvo.1	+	1	848	c.848T>C	c.(847-849)TTC>TCC	p.F283S		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATCTCCCTTTTCTATGGAGTG	0.408													C	107332296	C	C	107332296	3	2	93	1	0	0	0	0	1	0	0	0	10938	1783	62	4	850	4	OR13C8	9	107332296	Missense_Mutation	SNP	T	TCGA-06-5417-01A-01D-1486-08	69809412	107332296	33881135	35	6230											
OR4S1	256148	broad.mit.edu	37	chr11	48328474	48328474	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	catctgaggaccggcgtaagGctgtctccacatgtggctca	12	12	3	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr11:48328474G>T	uc010rhu.1	+	1	700	c.700G>T	c.(700-702)GCT>TCT	p.A234S		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S,	234	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCGGCGTAAGGCTGTCTCCAC	0.468													T	48328474	T	T	48328474	3	4	93	1	0	0	0	0	1	0	0	0	11082	1203	42	5	702	5	OR4S1	11	48328474	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08		48328474	86678042	36	6231											
CD5	921	broad.mit.edu	37	chr11	60890382	60890382	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctccttccccaggccAggatccaaaccccgcaggcc	7	20	1	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr11:60890382A>G	uc009ynk.2	+	7	1206	c.1103A>G	c.(1102-1104)CAG>CGG	p.Q368R		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	368	Extracellular (Potential).|SRCR 3.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		TCCCCAGGCCAGGATCCAAAC	0.657													G	60890382	G	G	60890382	3	3	93	1	0	0	0	0	1	0	0	0	3021	188	7	4	1129	4	CD5	11	60890382	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08	12561908	60890382	74116134	37	6232											
TUT1	64852	broad.mit.edu	37	chr11	62343579	62343579	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggtcctggagattcagggGgccaaggcgcagaccctccc	15	13	1	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr11:62343579G>A	uc001nto.2	-	9	1764	c.1726C>T	c.(1726-1728)CCC>TCC	p.P576S	EEF1G_uc001ntm.1_5'Flank|EEF1G_uc010rlw.1_5'Flank|TUT1_uc001ntp.1_Missense_Mutation_p.P72S	NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	538	PAP-associated.				mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						AGATTCAGGGGGCCAAGGCGC	0.637													A	62343579	A	A	62343579	3	1	93	1	0	0	0	0	1	0	0	0	16777	1232	43	3	1016	3	TUT1	11	62343579	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	1453197	62343579	72662937	38	6233											
C11orf92	399948	broad.mit.edu	37	chr11	111166838	111166838	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accaaaactcattaatgttgAgctacaaaccagagggaagc	8	9	1	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr11:111166838A>G	uc001pld.2	-	2	2775	c.366T>C	c.(364-366)GCT>GCC	p.A122A	C11orf92_uc001ple.2_RNA	NM_207429	NP_997312			hypothetical protein LOC399948											lung(1)	1						ATTAATGTTGAGCTACAAACC	0.433													G	111166838	G	G	111166838	2	3	93	1	0	0	0	0	0	0	0	1	1672	291	11	4		4	C11orf92	11	111166838	Silent	SNP	A	TCGA-06-5417-01A-01D-1486-08	48823259	111166838	23839678	39	6234											
BUD13	84811	broad.mit.edu	37	chr11	116627935	116627935	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggtgctggaccactgtagcGaggtctcactaatgagagga	14	8	1	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr11:116627935G>A	uc001ppn.2	-	9	1727	c.1693C>T	c.(1693-1695)CGC>TGC	p.R565C	BUD13_uc001ppo.2_Missense_Mutation_p.R431C	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	565										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		CCACTGTAGCGAGGTCTCACT	0.398													A	116627935	A	A	116627935	3	1	93	1	0	0	0	0	1	0	0	0	1573	1058	37	2	174	2	BUD13	11	116627935	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	5461097	116627935	18378581	40	6235											
PLEKHG6	55200	broad.mit.edu	37	chr12	6424277	6424277	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcactgggagataggagaggGtggcgacagtggcctgacca	18	8	0	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr12:6424277G>A	uc001qnr.2	+	4	549	c.401G>A	c.(400-402)GGT>GAT	p.G134D	PLEKHG6_uc001qns.2_Missense_Mutation_p.G134D|PLEKHG6_uc010sew.1_Missense_Mutation_p.G134D|PLEKHG6_uc010sex.1_Missense_Mutation_p.G102D	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	134					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						ATAGGAGAGGGTGGCGACAGT	0.632													A	6424277	A	A	6424277	3	1	93	1	0	0	0	0	1	0	0	0	12074	1261	44	3	457	3	PLEKHG6	12	6424277	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08		6424277	127427618	41	6236											
LRP1	4035	broad.mit.edu	37	chr12	57563089	57563089	+	Frame_Shift_Del	DEL	G	-	-													cacgccaactgcaccaaccaGggtgggcaccaggggcccgt							TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr12:57563089delG	uc001snd.2	+	20	3628	c.3162delG	c.(3160-3162)CAGfs	p.Q1054fs	LRP1_uc009zpi.1_RNA	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1054	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCACCAACCAGGGTGGGCACC	0.557													-	57563089	-	-	57563089	7	5	93	1	0	1	0	1	0	0	0	0	8951	1014	35	0	3240	0	LRP1	12	57563089	Frame_Shift_Del	DEL	G	TCGA-06-5417-01A-01D-1486-08	51138812	57563089	76288806	42	6237											
LRRIQ1	84125	broad.mit.edu	37	chr12	85450521	85450521	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagaacccaaaagacaatgcTtggaatagtggcattgtgat	11	6	0	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr12:85450521T>C	uc001tac.2	+	8	2061	c.1950T>C	c.(1948-1950)GCT>GCC	p.A650A	LRRIQ1_uc001tab.1_Silent_p.A650A|LRRIQ1_uc001taa.1_Silent_p.A625A	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	650										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		AAGACAATGCTTGGAATAGTG	0.313													C	85450521	C	C	85450521	2	2	93	1	0	0	0	0	0	0	0	1	9029	1596	56	4		4	LRRIQ1	12	85450521	Silent	SNP	T	TCGA-06-5417-01A-01D-1486-08	27887432	85450521	48401374	43	6238											
NR2C1	7181	broad.mit.edu	37	chr12	95442924	95442924	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgaatctccagtgattaggtGtacacttccttccatgcccg	8	12	1	2	rs149986233		TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr12:95442924G>T	uc001tdm.3	-	9	1307	c.1051C>A	c.(1051-1053)CAC>AAC	p.H351N	NR2C1_uc010suu.1_Missense_Mutation_p.H351N|NR2C1_uc001tdo.3_Missense_Mutation_p.H351N|NR2C1_uc001tdn.3_Missense_Mutation_p.H351N	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	351					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1						GTGATTAGGTGTACACTTCCT	0.443													T	95442924	T	T	95442924	3	4	93	1	0	0	0	0	1	0	0	0	10622	1377	48	5	862	5	NR2C1	12	95442924	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	9992403	95442924	38408971	44	6239											
ELK3	2004	broad.mit.edu	37	chr12	96640864	96640864	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaaggcgtctccggagggCcgcgaggcccacaaacacgg	15	14	1	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr12:96640864C>T	uc001teo.1	+	3	633	c.354C>T	c.(352-354)GGC>GGT	p.G118G		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	118					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)					CTCCGGAGGGCCGCGAGGCCC	0.612													T	96640864	T	T	96640864	2	4	93	1	0	0	0	0	0	0	0	1	5060	726	26	3		3	ELK3	12	96640864	Silent	SNP	C	TCGA-06-5417-01A-01D-1486-08	1197940	96640864	37211031	45	6240											
TPTE2	93492	broad.mit.edu	37	chr13	20039439	20039439	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caaatccatcccttgtgtatCgccttttgttttctgaaacc	5	12	1	1	rs146223410		TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr13:20039439C>T	uc001umd.2	-	10	843	c.632G>A	c.(631-633)CGA>CAA	p.R211Q	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.R100Q|TPTE2_uc001ume.2_Missense_Mutation_p.R134Q|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	211	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CCTTGTGTATCGCCTTTTGTT	0.308													T	20039439	T	T	20039439	3	4	93	1	0	0	0	0	1	0	0	0	16428	884	31	2	984	2	TPTE2	13	20039439	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08		20039439	95130439	46	6241											
GZMB	3002	broad.mit.edu	37	chr14	25102156	25102156	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagctgtcagcacgaagtcGtctcgtatcaggaagccacc	11	13	3	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr14:25102156G>A	uc001wps.2	-	2	234	c.168C>T	c.(166-168)GAC>GAT	p.D56D	GZMB_uc010ama.2_Silent_p.D44D|GZMB_uc010amb.2_RNA	NM_004131	NP_004122	P10144	GRAB_HUMAN	granzyme B precursor	56	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.028)		GCACGAAGTCGTCTCGTATCA	0.572													A	25102156	A	A	25102156	2	1	93	1	0	0	0	0	0	0	0	1	6916	1136	40	1		1	GZMB	14	25102156	Silent	SNP	G	TCGA-06-5417-01A-01D-1486-08		25102156	82247384	47	6242											
RYR3	6263	broad.mit.edu	37	chr15	34137199	34137199	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtatatggcaccaaccctgcGtgccctggccatcatccata	8	15	1	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr15:34137199G>T	uc001zhi.2	+	93	13503	c.13433G>T	c.(13432-13434)CGT>CTT	p.R4478L	RYR3_uc010bar.2_Missense_Mutation_p.R4473L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4478					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCAACCCTGCGTGCCCTGGCC	0.502													T	34137199	T	T	34137199	3	4	93	1	0	0	0	0	1	0	0	0	13770	1145	40	5	13803	5	RYR3	15	34137199	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08		34137199	68394193	48	6243											
LACTB	114294	broad.mit.edu	37	chr15	63433763	63433763	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatggcgtggggtgttgtggAaaggaaacaaacgtatggtt	16	3	0	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr15:63433763A>G	uc002alw.2	+	6	1442	c.1403A>G	c.(1402-1404)GAA>GGA	p.E468G		NM_032857	NP_116246	P83111	LACTB_HUMAN	lactamase, beta isoform a	468						mitochondrion	hydrolase activity				0						GGTGTTGTGGAAAGGAAACAA	0.483													G	63433763	G	G	63433763	3	3	93	1	0	0	0	0	1	0	0	0	8597	246	9	4	1429	4	LACTB	15	63433763	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08	29296564	63433763	39097629	49	6244											
BAIAP3	8938	broad.mit.edu	37	chr16	1392020	1392020	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgtatccctggtagaagcGtgcaggaagctgaatgaagt	14	6	0	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr16:1392020G>A	uc002clk.1	+	10	915	c.915G>A	c.(913-915)GCG>GCA	p.A305A	BAIAP3_uc002clj.2_Silent_p.A287A|BAIAP3_uc010uuz.1_Silent_p.A270A|BAIAP3_uc010uva.1_Silent_p.A242A|BAIAP3_uc010uvb.1_Silent_p.A322A|BAIAP3_uc010uvc.1_Silent_p.A270A	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	305	C2 1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				TGGTAGAAGCGTGCAGGAAGC	0.617													A	1392020	A	A	1392020	2	1	93	1	0	0	0	0	0	0	0	1	1304	1132	40	1		1	BAIAP3	16	1392020	Silent	SNP	G	TCGA-06-5417-01A-01D-1486-08		1392020	88962733	50	6245											
PPL	5493	broad.mit.edu	37	chr16	4952435	4952435	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctccaccagtgccgcccagTtgacctgtggatccacttcc	8	18	0	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr16:4952435T>C	uc002cyd.1	-	4	500	c.410A>G	c.(409-411)AAC>AGC	p.N137S		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	137					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TGCCGCCCAGTTGACCTGTGG	0.637													C	4952435	C	C	4952435	3	2	93	1	0	0	0	0	1	0	0	0	12334	1725	60	4	4936	4	PPL	16	4952435	Missense_Mutation	SNP	T	TCGA-06-5417-01A-01D-1486-08	3560415	4952435	85402318	51	6246											
TP53	7157	broad.mit.edu	37	chr17	7577517	7577517	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acctggagtcttccagtgtgAtgatggtgaggatgggcctc	15	8	1	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr17:7577517A>C	uc002gim.2	-	7	958	c.764T>G	c.(763-765)ATC>AGC	p.I255S	TP53_uc002gig.1_Missense_Mutation_p.I255S|TP53_uc002gih.2_Missense_Mutation_p.I255S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.I123S|TP53_uc010cng.1_Missense_Mutation_p.I123S|TP53_uc002gii.1_Missense_Mutation_p.I123S|TP53_uc010cnh.1_Missense_Mutation_p.I255S|TP53_uc010cni.1_Missense_Mutation_p.I255S|TP53_uc002gij.2_Missense_Mutation_p.I255S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.I162S|TP53_uc002gio.2_Missense_Mutation_p.I123S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	255	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> T (in sporadic cancers; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> M (in sporadic cancers; somatic mutation).|I -> V (in sporadic cancers; somatic mutation).|I -> N (in sporadic cancers; somatic mutation).|I -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I255F(16)|p.0?(7)|p.I255T(7)|p.I255del(7)|p.I255S(7)|p.I255N(7)|p.I255fs*90(4)|p.I255fs*9(3)|p.I255V(3)|p.T253_I255del(2)|p.I255I(2)|p.I255fs*8(1)|p.?(1)|p.I254fs*7(1)|p.I255M(1)|p.I254_T256del(1)|p.R249_T256delRPILTIIT(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCCAGTGTGATGATGGTGAG	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7577517	C	C	7577517	3	2	93	1	0	0	0	0	1	0	0	0	16378	333	12	5	526	5	TP53	17	7577517	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08		7577517	73617693	52	6247											
TP53	7157	broad.mit.edu	37	chr17	7578263	7578263	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgcaaatttccttccactcGgataagatgctgaggagggg	12	9	0	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr17:7578263G>A	uc002gim.2	-	6	780	c.586C>T	c.(586-588)CGA>TGA	p.R196*	TP53_uc002gig.1_Nonsense_Mutation_p.R196*|TP53_uc002gih.2_Nonsense_Mutation_p.R196*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R64*|TP53_uc010cng.1_Nonsense_Mutation_p.R64*|TP53_uc002gii.1_Nonsense_Mutation_p.R64*|TP53_uc010cnh.1_Nonsense_Mutation_p.R196*|TP53_uc010cni.1_Nonsense_Mutation_p.R196*|TP53_uc002gij.2_Nonsense_Mutation_p.R196*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R103*|TP53_uc002gio.2_Nonsense_Mutation_p.R64*|TP53_uc010vug.1_Nonsense_Mutation_p.R157*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(125)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.R196L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R64*(1)|p.I195fs*12(1)|p.R103*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578263	A	A	7578263	4	1	93	1	0	0	0	0	0	1	0	0	16378	1124	39	2	708	2	TP53	17	7578263	Nonsense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	746	7578263	73616947	53	6248											
POLDIP2	26073	broad.mit.edu	37	chr17	26675209	26675209	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tccagggagaagggaggaatCcgaacatcaaagtgggagcc	15	8	1	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr17:26675209C>A	uc002haz.2	-	14	1173	c.1041G>T	c.(1039-1041)CGG>CGT	p.R347R	POLDIP2_uc010wag.1_RNA	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2	347	ApaG.					mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGGGAGGAATCCGAACATCAA	0.547													A	26675209	A	A	26675209	2	1	93	1	0	0	0	0	0	0	0	1	12194	842	30	5		5	POLDIP2	17	26675209	Silent	SNP	C	TCGA-06-5417-01A-01D-1486-08	19096946	26675209	54520001	54	6249											
CDK12	51755	broad.mit.edu	37	chr17	37618715	37618716	+	Frame_Shift_Ins	INS	-	A	A													agctaaacagaccgaaaaagINSaaaaaagccaagaagtctcc							TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr17:37618715_37618716insA	uc010cvv.2	+	1	977_978	c.391_392insA	c.(391-393)GAAfs	p.E131fs	CDK12_uc010wef.1_Frame_Shift_Ins_p.E131fs|CDK12_uc002hrw.3_Frame_Shift_Ins_p.E131fs	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	131					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GACCGAAAAAGAAAAAAGCCAA	0.52										TCGA Ovarian(9;0.13)			A	37618716	A	A	37618715	7	5	93	1	0	1	1	0	0	0	0	0	3128	943	33	0	393	0	CDK12	17	37618715	Frame_Shift_Ins	INS	-	TCGA-06-5417-01A-01D-1486-08	10943506	37618715	43576495	55	6250											
ZNF544	27300	broad.mit.edu	37	chr19	58772645	58772645	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgctagagctttctgtcagAgtatttacttgagtaaactt	9	6	2	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr19:58772645A>C	uc010euo.2	+	7	1147	c.673A>C	c.(673-675)AGT>CGT	p.S225R	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.S197R|ZNF544_uc010yhy.1_Missense_Mutation_p.S197R|ZNF544_uc002qrt.3_Missense_Mutation_p.S83R|ZNF544_uc002qru.3_Missense_Mutation_p.S83R|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TTTCTGTCAGAGTATTTACTT	0.378													C	58772645	C	C	58772645	3	2	93	1	0	0	0	0	1	0	0	0	17974	304	11	5	687	5	ZNF544	19	58772645	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08		58772645	356338	56	6251											
PANX2	56666	broad.mit.edu	37	chr22	50615879	50615879	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtgcccatctcctacctgtgCacctactacgccacgcagaa	7	17	1	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chr22:50615879C>A	uc003bjn.3	+	2	738	c.738C>A	c.(736-738)TGC>TGA	p.C246*	PANX2_uc003bjp.3_Nonsense_Mutation_p.C112*|PANX2_uc003bjo.3_Nonsense_Mutation_p.C246*	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	246	Helical; (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		CCTACCTGTGCACCTACTACG	0.706													A	50615879	A	A	50615879	4	1	93	1	0	0	0	0	0	1	0	0	11421	718	25	5	744	5	PANX2	22	50615879	Nonsense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08		50615879	688687	57	6252											
GEMIN8	54960	broad.mit.edu	37	chrX	14027172	14027172	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgcttcatctcggcctggcGccgctcaccaggcctctcag	10	18	4	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:14027172G>A	uc004cwb.2	-	5	932	c.589C>T	c.(589-591)CGC>TGC	p.R197C	GEMIN8_uc004cwc.2_Missense_Mutation_p.R197C|GEMIN8_uc004cwd.2_Missense_Mutation_p.R197C	NM_017856	NP_060326	Q9NWZ8	GEMI8_HUMAN	gem (nuclear organelle) associated protein 8	197					spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding				0						TCGGCCTGGCGCCGCTCACCA	0.612													A	14027172	A	A	14027172	3	1	93	1	0	0	0	0	1	0	0	0	6334	1087	38	1	143	1	GEMIN8	23	14027172	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08		14027172	141243388	58	6253											
ZNF645	158506	broad.mit.edu	37	chrX	22292090	22292090	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atccatcatctggatatattAttgtaaaggtgccacctgat	7	8	2	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:22292090A>T	uc004dai.1	+	1	1031	c.982A>T	c.(982-984)ATT>TTT	p.I328F		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	328	Pro-rich.					intracellular	zinc ion binding			lung(1)|pancreas(1)	2						TGGATATATTATTGTAAAGGT	0.438													T	22292090	T	T	22292090	3	4	93	1	0	0	0	0	1	0	0	0	18058	449	16	5	984	5	ZNF645	23	22292090	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08	8264918	22292090	132978470	59	6254											
CXorf22	170063	broad.mit.edu	37	chrX	35985840	35985840	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcttcaatcagccatgacaCgcactcacaatcatcgctca	5	15	5	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:35985840C>T	uc004ddj.2	+	10	1764	c.1705C>T	c.(1705-1707)CGC>TGC	p.R569C	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	569										large_intestine(1)|lung(1)|ovary(1)	3						AGCCATGACACGCACTCACAA	0.453													T	35985840	T	T	35985840	3	4	93	1	0	0	0	0	1	0	0	0	4102	536	19	1	1743	1	CXorf22	23	35985840	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08	13693750	35985840	119284720	60	6255											
EFHC2	80258	broad.mit.edu	37	chrX	44037748	44037748	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctcaggcacacggtagtgaCgtgcaatggttacaaattct	10	10	2	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:44037748C>A	uc004dgb.3	-	13	1904	c.1814G>T	c.(1813-1815)CGT>CTT	p.R605L		NM_025184	NP_079460	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	605							calcium ion binding			breast(3)|ovary(2)|central_nervous_system(1)	6						ACGGTAGTGACGTGCAATGGT	0.373													A	44037748	A	A	44037748	3	1	93	1	0	0	0	0	1	0	0	0	4947	536	19	5	451	5	EFHC2	23	44037748	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08	8051908	44037748	111232812	61	6256											
ZNF674	641339	broad.mit.edu	37	chrX	46388335	46388335	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacaaacacgtccttgaaggTcaatgattcctgtaacggca	8	11	1	2			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:46388335T>C	uc004dgr.2	-	4	252	c.25A>G	c.(25-27)ACC>GCC	p.T9A	ZNF674_uc011mlg.1_Missense_Mutation_p.T9A|ZNF674_uc010nhm.2_Missense_Mutation_p.T9A	NM_001039891	NP_001034980	Q2M3X9	ZN674_HUMAN	zinc finger family member 674 isoform 1	9	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)	2						TCCTTGAAGGTCAATGATTCC	0.498													C	46388335	C	C	46388335	3	2	93	1	0	0	0	0	1	0	0	0	18078	1667	58	4	1732	4	ZNF674	23	46388335	Missense_Mutation	SNP	T	TCGA-06-5417-01A-01D-1486-08	2350587	46388335	108882225	62	6257											
CCDC120	90060	broad.mit.edu	37	chrX	48920041	48920041	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccccaggtgaagtcagagcGtctgcgggggctgcttgacc	15	13	2	3	rs147084360		TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:48920041G>A	uc010nik.2	+	4	599	c.92G>A	c.(91-93)CGT>CAT	p.R31H	CCDC120_uc011mmq.1_Missense_Mutation_p.R19H|CCDC120_uc004dmf.2_Missense_Mutation_p.R31H|CCDC120_uc010nil.2_Missense_Mutation_p.R31H|CCDC120_uc011mmr.1_Missense_Mutation_p.R31H|CCDC120_uc011mms.1_Missense_Mutation_p.R19H|CCDC120_uc004dmg.1_Silent_p.A109A	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	31							protein binding			pancreas(1)	1						AAGTCAGAGCGTCTGCGGGGG	0.647													A	48920041	A	A	48920041	3	1	93	1	0	0	0	0	1	0	0	0	2756	1145	40	1	98	1	CCDC120	23	48920041	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	2531706	48920041	106350519	63	6258											
LAS1L	81887	broad.mit.edu	37	chrX	64737941	64737941	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcctagcattctcggcagtgGgggactcttgccctgtagag	14	11	2	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:64737941G>T	uc004dwa.1	-	12	1925	c.1853C>A	c.(1852-1854)CCC>CAC	p.P618H	LAS1L_uc004dwc.1_Missense_Mutation_p.P601H|LAS1L_uc004dwd.1_Missense_Mutation_p.P559H|LAS1L_uc004dvy.1_Missense_Mutation_p.P131H|LAS1L_uc004dvz.1_Missense_Mutation_p.P131H	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	618						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						CTCGGCAGTGGGGGACTCTTG	0.393													T	64737941	T	T	64737941	3	4	93	1	0	0	0	0	1	0	0	0	8636	1232	43	5	363	5	LAS1L	23	64737941	Missense_Mutation	SNP	G	TCGA-06-5417-01A-01D-1486-08	15817900	64737941	90532619	64	6259											
STARD8	9754	broad.mit.edu	37	chrX	67943638	67943638	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gtggagctgtaccactatgtCaccgacagcatggcacccca	10	14	1	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:67943638C>G	uc004dxa.2	+	12	3102	c.2730C>G	c.(2728-2730)GTC>GTG	p.V910V	STARD8_uc004dxb.2_Silent_p.V990V|STARD8_uc004dxc.3_Silent_p.V910V	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	910	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						ACCACTATGTCACCGACAGCA	0.652													G	67943638	G	G	67943638	2	3	93	1	0	0	0	0	0	0	0	1	15262	813	29	5		5	STARD8	23	67943638	Silent	SNP	C	TCGA-06-5417-01A-01D-1486-08	3205697	67943638	87326922	65	6260											
ZMYM3	9203	broad.mit.edu	37	chrX	70469372	70469372	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttgttggccctcgtggaagAggagctcagggccaggactc	15	10	1	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:70469372A>G	uc004dzh.1	-	7	1496	c.1409T>C	c.(1408-1410)CTC>CCC	p.L470P	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.L470P|ZMYM3_uc004dzj.1_Missense_Mutation_p.L470P|ZMYM3_uc011mpu.1_Missense_Mutation_p.L201P|ZMYM3_uc004dzk.3_Missense_Mutation_p.L470P|ZMYM3_uc004dzl.3_Missense_Mutation_p.L470P|ZMYM3_uc004dzm.3_Missense_Mutation_p.L470P	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	470					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CTCGTGGAAGAGGAGCTCAGG	0.562													G	70469372	G	G	70469372	3	3	93	1	0	0	0	0	1	0	0	0	17698	304	11	4	2797	4	ZMYM3	23	70469372	Missense_Mutation	SNP	A	TCGA-06-5417-01A-01D-1486-08	2525734	70469372	84801188	66	6261											
ATRX	546	broad.mit.edu	37	chrX	76778818	76778818	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtccaaaagagaatcaTgttcatggtatcctacaatg	9	7	2	1			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:76778818T>C	uc004ecp.3	-	31	6993	c.6761A>G	c.(6760-6762)CAT>CGT	p.H2254R	ATRX_uc004ecq.3_Missense_Mutation_p.H2216R|ATRX_uc004eco.3_Missense_Mutation_p.H2039R	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2254					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AAGAGAATCATGTTCATGGTA	0.388			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						C	76778818	C	C	76778818	3	2	93	1	0	0	0	0	1	0	0	0	1208	1464	51	4	737	4	ATRX	23	76778818	Missense_Mutation	SNP	T	TCGA-06-5417-01A-01D-1486-08	6309446	76778818	78491742	67	6262											
HDX	139324	broad.mit.edu	37	chrX	83724095	83724095	+	Frame_Shift_Del	DEL	C	-	-													ggtcggtggcacacagaaggCttttgaggtactgtcatttc							TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:83724095delC	uc004eek.1	-	3	745	c.636delG	c.(634-636)AAGfs	p.K212fs	HDX_uc011mqv.1_Frame_Shift_Del_p.K212fs|HDX_uc004eel.1_Frame_Shift_Del_p.K154fs	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	212						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						ACACAGAAGGCTTTTGAGGTA	0.418													-	83724095	-	-	83724095	7	5	93	1	0	1	0	1	0	0	0	0	7026	796	28	0	1468	0	HDX	23	83724095	Frame_Shift_Del	DEL	C	TCGA-06-5417-01A-01D-1486-08	6945277	83724095	71546465	68	6263											
COL4A5	1287	broad.mit.edu	37	chrX	107840792	107840792	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggcttcctggcccgaaaggAgagcctgtgagttggtttga	16	8	0	3			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:107840792A>G	uc004enz.1	+	24	1975	c.1773A>G	c.(1771-1773)GGA>GGG	p.G591G	COL4A5_uc011mso.1_Silent_p.G591G|COL4A5_uc004eob.1_Silent_p.G199G	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	591	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GCCCGAAAGGAGAGCCTGTGA	0.463									Alport_syndrome_with_Diffuse_Leiomyomatosis				G	107840792	G	G	107840792	2	3	93	1	0	0	0	0	0	0	0	1	3694	291	11	4		4	COL4A5	23	107840792	Silent	SNP	A	TCGA-06-5417-01A-01D-1486-08	24116697	107840792	47429768	69	6264											
GUCY2F	2986	broad.mit.edu	37	chrX	108708484	108708484	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcaacactgcatcataggCttcccggagctttgggttgt	12	10	2	0			TCGA-06-5417-01A-01D-1486-08	TCGA-06-5417-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	66350d36-6662-4d4c-9cf8-e052a17cddba	07503119-3ce1-41af-85e6-3f90b92a8c62	g.chrX:108708484C>T	uc004eod.3	-	3	1195	c.919G>A	c.(919-921)GCC>ACC	p.A307T	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	307	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						GCATCATAGGCTTCCCGGAGC	0.488													T	108708484	T	T	108708484	3	4	93	1	0	0	0	0	1	0	0	0	6898	797	28	3	2475	3	GUCY2F	23	108708484	Missense_Mutation	SNP	C	TCGA-06-5417-01A-01D-1486-08	867692	108708484	46562076	70	6265											
GPR153	387509	broad.mit.edu	37	chr1	6311445	6311445	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagggccatgcacttctccCggacagctttgaggtcagcc	12	13	2	2	rs139457263		TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr1:6311445C>T	uc001amp.1	-	4	1192	c.932G>A	c.(931-933)CGG>CAG	p.R311Q	GPR153_uc001amo.1_5'Flank	NM_207370	NP_997253	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	311	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		GCACTTCTCCCGGACAGCTTT	0.637													T	6311445	T	T	6311445	3	4	94	1	0	0	0	0	1	0	0	0	6659	652	23	2	909	2	GPR153	1	6311445	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08		6311445	242939176	1	6266											
DMBX1	127343	broad.mit.edu	37	chr1	46976764	46976764	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggacactgagcagcccccacGtctgcctggcagcgaccccc	11	19	1	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr1:46976764G>A	uc001cpx.2	+	3	521	c.506G>A	c.(505-507)CGT>CAT	p.R169H	DMBX1_uc001cpw.2_Missense_Mutation_p.R164H	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	169					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CAGCCCCCACGTCTGCCTGGC	0.652													A	46976764	A	A	46976764	3	1	94	1	0	0	0	0	1	0	0	0	4578	1145	40	1	516	1	DMBX1	1	46976764	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08	40665319	46976764	202273857	2	6267											
TCHH	7062	broad.mit.edu	37	chr1	152081245	152081245	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctccaggaattttctgtcaCgctcttggcggtgcagctgc	11	13	3	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr1:152081245C>T	uc001ezp.2	-	2	4448	c.4448G>A	c.(4447-4449)CGT>CAT	p.R1483H	TCHH_uc009wne.1_Missense_Mutation_p.R1483H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1483	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTTCTGTCACGCTCTTGGCG	0.557													T	152081245	T	T	152081245	3	4	94	1	0	0	0	0	1	0	0	0	15697	536	19	1	1387	1	TCHH	1	152081245	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	105104481	152081245	97169376	3	6268											
F5	2153	broad.mit.edu	37	chr1	169509611	169509611	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgtttccattgttgctgcGgaggtaccatgctgcaatgt	11	9	1	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr1:169509611G>A	uc001ggg.1	-	13	4862	c.4717C>T	c.(4717-4719)CGC>TGC	p.R1573C		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1573	B.	Cleavage; by thrombin.			cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTGTTGCTGCGGAGGTACCAT	0.398													A	169509611	A	A	169509611	3	1	94	1	0	0	0	0	1	0	0	0	5348	1116	39	2	2009	2	F5	1	169509611	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08	17428366	169509611	79741010	4	6269											
IPO9	55705	broad.mit.edu	37	chr1	201823997	201823997	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccaaagcacatggtgtcctCcatgcagcagattctgccta	8	14	1	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr1:201823997C>T	uc001gwz.2	+	8	907	c.857C>T	c.(856-858)TCC>TTC	p.S286F		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	286					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						ATGGTGTCCTCCATGCAGCAG	0.403													T	201823997	T	T	201823997	3	4	94	1	0	0	0	0	1	0	0	0	7799	855	30	3	887	3	IPO9	1	201823997	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	32314386	201823997	47426624	5	6270											
ABCG5	64240	broad.mit.edu	37	chr2	44065792	44065792	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagacccatggaccctccGggggtcaaagatgagaggtc	15	10	1	3	rs72542428		TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr2:44065792G>A	uc002rtn.2	-	1	167	c.27C>T	c.(25-27)CCC>CCT	p.P9P	ABCG5_uc002rto.2_5'UTR|ABCG5_uc002rtp.2_5'UTR|ABCG8_uc002rtq.2_5'Flank|ABCG8_uc010yoa.1_5'Flank	NM_022436	NP_071881	Q9H222	ABCG5_HUMAN	ATP-binding cassette sub-family G member 5	9	Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGGACCCTCCGGGGGTCAAAG	0.637													A	44065792	A	A	44065792	2	1	94	1	0	0	0	0	0	0	0	1	71	1103	39	2		2	ABCG5	2	44065792	Silent	SNP	G	TCGA-06-5418-01A-01D-1486-08		44065792	199133581	6	6271											
SPTBN1	6711	broad.mit.edu	37	chr2	54856719	54856719	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcccccaggagcatgccgaGtctccagacgtgaggggcag	14	14	1	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr2:54856719G>A	uc002rxu.2	+	14	2697	c.2448G>A	c.(2446-2448)GAG>GAA	p.E816E	SPTBN1_uc002rxv.1_Silent_p.E816E|SPTBN1_uc002rxx.2_Silent_p.E803E	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	816	Spectrin 5.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGCATGCCGAGTCTCCAGACG	0.627													A	54856719	A	A	54856719	2	1	94	1	0	0	0	0	0	0	0	1	15118	1020	36	3		3	SPTBN1	2	54856719	Silent	SNP	G	TCGA-06-5418-01A-01D-1486-08	10790927	54856719	188342654	7	6272											
GTDC1	79712	broad.mit.edu	37	chr2	144899603	144899603	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attaaaaactgagttgaataCaaccacatcagccaccaggc	6	11	1	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr2:144899603C>T	uc002tvp.2	-	6	646	c.367G>A	c.(367-369)GTA>ATA	p.V123I	GTDC1_uc002tvo.2_Missense_Mutation_p.V123I|GTDC1_uc002tvq.2_Missense_Mutation_p.V123I|GTDC1_uc002tvr.2_Missense_Mutation_p.V123I|GTDC1_uc010fnn.2_Missense_Mutation_p.V123I|GTDC1_uc002tvs.2_Missense_Mutation_p.V91I|GTDC1_uc010fno.2_5'UTR|GTDC1_uc002tvt.1_Missense_Mutation_p.V123I	NM_001006636	NP_001006637	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	123					biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)		GAGTTGAATACAACCACATCA	0.383													T	144899603	T	T	144899603	3	4	94	1	0	0	0	0	1	0	0	0	6851	478	17	3	1037	3	GTDC1	2	144899603	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	90042884	144899603	98299770	8	6273											
GALNT3	2591	broad.mit.edu	37	chr2	166627133	166627133	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actattataaagaaaaaaatTactgcaccaagcttccagaa	4	8	0	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr2:166627133T>C	uc010fph.1	-	2	465	c.78A>G	c.(76-78)GTA>GTG	p.V26V	GALNT3_uc010fpi.1_Silent_p.V26V|GALNT3_uc002udi.2_Silent_p.V26V	NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	26	Helical; Signal-anchor for type II membrane protein; (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						AGAAAAAAATTACTGCACCAA	0.313													C	166627133	C	C	166627133	2	2	94	1	0	0	0	0	0	0	0	1	6214	1741	61	4		4	GALNT3	2	166627133	Silent	SNP	T	TCGA-06-5418-01A-01D-1486-08	21727530	166627133	76572240	9	6274											
TLK1	9874	broad.mit.edu	37	chr2	171902709	171902710	+	Frame_Shift_Ins	INS	-	GG	GG													ggtaaatttggtctaacaaaINSgggatcattctctgctccat							TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr2:171902709_171902710insGG	uc002ugn.2	-	11	1615_1616	c.1143_1144insCC	c.(1141-1146)CCCTTTfs	p.P381fs	TLK1_uc002ugo.2_Frame_Shift_Ins_p.P402fs|TLK1_uc002ugp.2_Frame_Shift_Ins_p.P333fs|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Frame_Shift_Ins_p.P285fs|TLK1_uc002ugr.1_Frame_Shift_Ins_p.P164fs	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	381_382					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						GGTCTAACAAAGGGATCATTCT	0.366													GG	171902710	GG	GG	171902709	7	5	94	1	0	1	1	0	0	0	0	0	15940	72	3	0	1200	0	TLK1	2	171902709	Frame_Shift_Ins	INS	-	TCGA-06-5418-01A-01D-1486-08	5275576	171902709	71296664	10	6275											
CAMK1	8536	broad.mit.edu	37	chr3	9799491	9799491	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgcccagctgcagttTcctcatgtgccgcaccacag	11	15	1	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr3:9799491T>A	uc003bst.2	-	11	1130	c.952A>T	c.(952-954)AAA>TAA	p.K318*	OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|CAMK1_uc003bsu.2_RNA|CAMK1_uc003bss.2_Nonsense_Mutation_p.K92*|uc003bsv.1_5'Flank	NM_003656	NP_003647	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	318	Nuclear export signal (By similarity).				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|skin(1)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		AGCTGCAGTTTCCTCATGTGC	0.612													A	9799491	A	A	9799491	4	1	94	1	0	0	0	0	0	1	0	0	2596	1792	62	5	168	5	CAMK1	3	9799491	Nonsense_Mutation	SNP	T	TCGA-06-5418-01A-01D-1486-08		9799491	188222939	11	6276											
VHL	7428	broad.mit.edu	37	chr3	10183867	10183867	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccgccgcatccacagctaCcgaggtacgggcccggcgct	14	17	0	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr3:10183867C>T	uc003bvc.2	+	1	549	c.336C>T	c.(334-336)TAC>TAT	p.Y112Y	VHL_uc003bvd.2_Silent_p.Y112Y	NM_000551	NP_000542	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor isoform 1	112	Involved in binding to CCT complex.		Y -> H (in VHLD; type IIA).|Y -> N (in VHLD).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.?(1)|p.Y112*(1)|p.Y112D(1)|p.I109_R113del(1)|p.S111fs*45(1)|p.R113fs*46(1)|p.Y112fs*1(1)|p.S111_Y112del(1)|p.Y112fs*47(1)		kidney(1273)|soft_tissue(24)|adrenal_gland(15)|large_intestine(13)|pancreas(5)|endometrium(4)|thyroid(3)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|pleura(1)|paratesticular_tissues(1)	1346				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		TCCACAGCTACCGAGGTACGG	0.637		1	D|Mis|N|F|S		renal|hemangioma|pheochromocytoma	renal|hemangioma|pheochromocytoma			von_Hippel-Lindau_disease|Chuvash_Polycythemia_|Pheochromocytoma_(Adrenal)_Familial				T	10183867	T	T	10183867	2	4	94	1	0	0	0	0	0	0	0	1	17159	518	18	3		3	VHL	3	10183867	Silent	SNP	C	TCGA-06-5418-01A-01D-1486-08	384376	10183867	187838563	12	6277											
OR5K1	26339	broad.mit.edu	37	chr3	98188932	98188932	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	taggttagttttctgtggatCgaatcacatcaaccactttt	7	8	3	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr3:98188932C>T	uc003dsm.2	+	1	512	c.512C>T	c.(511-513)TCG>TTG	p.S171L		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						TTCTGTGGATCGAATCACATC	0.398													T	98188932	T	T	98188932	3	4	94	1	0	0	0	0	1	0	0	0	11166	893	31	2	514	2	OR5K1	3	98188932	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	88005065	98188932	99833498	13	6278											
FSTL1	11167	broad.mit.edu	37	chr3	120123732	120123732	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgttctcctggtctggataCgttgtaatattgatggcagt	11	6	2	1	rs138829728	by1000genomes	TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr3:120123732C>T	uc003eds.2	-	7	724	c.549G>A	c.(547-549)ACG>ACA	p.T183T	FSTL1_uc011bjh.1_Silent_p.T148T	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor	183					BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		GGTCTGGATACGTTGTAATAT	0.448													T	120123732	T	T	120123732	2	4	94	1	0	0	0	0	0	0	0	1	6077	523	19	1		1	FSTL1	3	120123732	Silent	SNP	C	TCGA-06-5418-01A-01D-1486-08	21934800	120123732	77898698	14	6279											
IGSF10	285313	broad.mit.edu	37	chr3	151166049	151166049	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccattttcctgataggcttCgaccaaaggttctaccacag	7	13	1	1	rs116716539	byFrequency	TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr3:151166049C>T	uc011bod.1	-	4	1720	c.1720G>A	c.(1720-1722)GAA>AAA	p.E574K		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	574	Ig-like C2-type 2.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGATAGGCTTCGACCAAAGGT	0.413													T	151166049	T	T	151166049	3	4	94	1	0	0	0	0	1	0	0	0	7597	893	31	2	6211	2	IGSF10	3	151166049	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	31042317	151166049	46856381	15	6280											
TMEM156	80008	broad.mit.edu	37	chr4	39000377	39000377	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcaagtcctggtgaagttacGaaaattggagggatttagaa	13	4	0	2	rs13118782		TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr4:39000377G>A	uc003gto.2	-	2	349	c.241C>T	c.(241-243)CGT>TGT	p.R81C	TMEM156_uc010ifj.2_Missense_Mutation_p.R81C	NM_024943	NP_079219	Q8N614	TM156_HUMAN	transmembrane protein 156	81	Extracellular (Potential).					integral to membrane				skin(1)	1						GTGAAGTTACGAAAATTGGAG	0.368													A	39000377	A	A	39000377	3	1	94	1	0	0	0	0	1	0	0	0	16070	1058	37	2	669	2	TMEM156	4	39000377	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08		39000377	152153899	16	6281											
UGT2B7	7364	broad.mit.edu	37	chr4	69973993	69973993	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtggacttcaacacaatgtcGagtacagacttgctgaatgc	10	9	1	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr4:69973993G>A	uc003heg.3	+	5	1309	c.1263G>A	c.(1261-1263)TCG>TCA	p.S421S	UGT2B7_uc010ihq.2_Intron	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	421					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						ACACAATGTCGAGTACAGACT	0.423													A	69973993	A	A	69973993	2	1	94	1	0	0	0	0	0	0	0	1	16959	1045	37	2		2	UGT2B7	4	69973993	Silent	SNP	G	TCGA-06-5418-01A-01D-1486-08	30973616	69973993	121180283	17	6282											
TRPC3	7222	broad.mit.edu	37	chr4	122833104	122833104	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	caccctgaagatctgtttggGatagtcagtaactgtgatat	10	7	2	3			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr4:122833104G>C	uc003ieg.2	-	5	1560	c.1486C>G	c.(1486-1488)CCC>GCC	p.P496A	TRPC3_uc010inr.2_Missense_Mutation_p.P368A|TRPC3_uc003ief.2_Missense_Mutation_p.P423A|TRPC3_uc011cgl.1_Missense_Mutation_p.P160A	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	411	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						ATCTGTTTGGGATAGTCAGTA	0.423													C	122833104	C	C	122833104	3	2	94	1	0	0	0	0	1	0	0	0	16576	1174	41	5	1311	5	TRPC3	4	122833104	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08	52859111	122833104	68321172	18	6283											
TBC1D9	23158	broad.mit.edu	37	chr4	141600954	141600954	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	taaacttctccgtgtcatcaTcttcctttacatcattgatt	3	11	5	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr4:141600954T>A	uc010ioj.2	-	4	676	c.404A>T	c.(403-405)GAT>GTT	p.D135V		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	135						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CGTGTCATCATCTTCCTTTAC	0.368													A	141600954	A	A	141600954	3	1	94	1	0	0	0	0	1	0	0	0	15624	1435	50	5	3468	5	TBC1D9	4	141600954	Missense_Mutation	SNP	T	TCGA-06-5418-01A-01D-1486-08	18767850	141600954	49553322	19	6284											
TERT	7015	broad.mit.edu	37	chr5	1260707	1260707	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactggctctgatggaggtcCgggcatagctgagacacagg	16	9	1	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr5:1260707C>T	uc003jcb.1	-	12	2910	c.2852G>A	c.(2851-2853)CGG>CAG	p.R951Q	TERT_uc003jbz.1_Missense_Mutation_p.R147Q|TERT_uc003jca.1_Missense_Mutation_p.R939Q|TERT_uc003jcc.1_Missense_Mutation_p.R888Q|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	951	CTE.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GATGGAGGTCCGGGCATAGCT	0.602									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				T	1260707	T	T	1260707	3	4	94	1	0	0	0	0	1	0	0	0	15761	652	23	2	566	2	TERT	5	1260707	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08		1260707	179654553	20	6285											
ZNF366	167465	broad.mit.edu	37	chr5	71752388	71752388	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccagcagggtgaactccCgcccacaaatcccacactta	8	16	0	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr5:71752388C>T	uc003kce.1	-	3	1553	c.1367G>A	c.(1366-1368)CGG>CAG	p.R456Q		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	456	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GGTGAACTCCCGCCCACAAAT	0.527													T	71752388	T	T	71752388	3	4	94	1	0	0	0	0	1	0	0	0	17867	652	23	2	879	2	ZNF366	5	71752388	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	70491681	71752388	109162872	21	6286											
GABRB2	2561	broad.mit.edu	37	chr5	160753407	160753407	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaatcgtaattggtagtccGtctagttggggagaggtttc	14	5	1	1	rs140795978		TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr5:160753407G>A	uc003lys.1	-	10	1377	c.1159C>T	c.(1159-1161)CGG>TGG	p.R387W	GABRB2_uc011deh.1_Intron|GABRB2_uc003lyr.1_Intron|GABRB2_uc003lyt.1_Intron|GABRB2_uc010jiu.1_Intron	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	387	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ttggtagtccgtctagttggg	0.159													A	160753407	A	A	160753407	3	1	94	1	0	0	0	0	1	0	0	0	6167	1144	40	1	387	1	GABRB2	5	160753407	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08	89001019	160753407	20161853	22	6287											
PKHD1	5314	broad.mit.edu	37	chr6	51941108	51941108	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggtggataaacttggtgaacGatgggtgtctgcgccttgga	16	6	1	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr6:51941108G>A	uc003pah.1	-	6	690	c.414C>T	c.(412-414)ATC>ATT	p.I138I	PKHD1_uc003pai.2_Silent_p.I138I	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	138	IPT/TIG 2.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTTGGTGAACGATGGGTGTCT	0.393													A	51941108	A	A	51941108	2	1	94	1	0	0	0	0	0	0	0	1	11971	1048	37	2		2	PKHD1	6	51941108	Silent	SNP	G	TCGA-06-5418-01A-01D-1486-08		51941108	119173959	23	6288											
KCNQ5	56479	broad.mit.edu	37	chr6	73843328	73843328	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgcttccggccctcgctgCgcctcaaaagttctcagcca	8	19	2	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr6:73843328C>T	uc003pgk.2	+	10	1779	c.1432C>T	c.(1432-1434)CGC>TGC	p.R478C	KCNQ5_uc011dyh.1_Missense_Mutation_p.R497C|KCNQ5_uc011dyi.1_Missense_Mutation_p.R488C|KCNQ5_uc010kat.2_Missense_Mutation_p.R469C|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Missense_Mutation_p.R228C	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	478					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GCCCTCGCTGCGCCTCAAAAG	0.512													T	73843328	T	T	73843328	3	4	94	1	0	0	0	0	1	0	0	0	8086	768	27	1	1531	1	KCNQ5	6	73843328	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	21902220	73843328	97271739	24	6289											
MACC1	346389	broad.mit.edu	37	chr7	20199376	20199376	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	caagttgtgtctgggcccatCcagggctctgactaattgta	11	10	2	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr7:20199376C>G	uc003sus.3	-	5	917	c.608G>C	c.(607-609)GGA>GCA	p.G203A	MACC1_uc010kug.2_Missense_Mutation_p.G203A	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	203					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						CTGGGCCCATCCAGGGCTCTG	0.473													G	20199376	G	G	20199376	3	3	94	1	0	0	0	0	1	0	0	0	9143	855	30	5	1962	5	MACC1	7	20199376	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08		20199376	138939287	25	6290											
AMPH	273	broad.mit.edu	37	chr7	38471801	38471801	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcttaccgtccataggtcCcagggcaatgtctgaaagca	11	11	1	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr7:38471801C>T	uc003tgu.2	-	13	1215	c.1146G>A	c.(1144-1146)TGG>TGA	p.W382*	AMPH_uc003tgv.2_Nonsense_Mutation_p.W382*|AMPH_uc003tgt.2_Nonsense_Mutation_p.W135*|AMPH_uc003tgw.1_5'Flank|AMPH_uc010kxl.1_5'Flank	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	382					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TCCATAGGTCCCAGGGCAATG	0.318													T	38471801	T	T	38471801	4	4	94	1	0	0	0	0	0	1	0	0	588	624	22	3	977	3	AMPH	7	38471801	Nonsense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	18272425	38471801	120666862	26	6291											
ADCY1	107	broad.mit.edu	37	chr7	45717648	45717648	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccctgaagtacaaacatgtcGaacgggagcaaaaggtaagc	11	9	0	1	rs147187783		TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr7:45717648G>A	uc003tne.3	+	9	1804	c.1786G>A	c.(1786-1788)GAA>AAA	p.E596K		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	596	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CAAACATGTCGAACGGGAGCA	0.557													A	45717648	A	A	45717648	3	1	94	1	0	0	0	0	1	0	0	0	292	1059	37	2	1820	2	ADCY1	7	45717648	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08	7245847	45717648	113421015	27	6292											
POM121L12	285877	broad.mit.edu	37	chr7	53103406	53103406	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtccgcagacctcgggaaCttctggaaggcgggagaacc	15	11	1	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr7:53103406C>T	uc003tpz.2	+	1	58	c.42C>T	c.(40-42)AAC>AAT	p.N14N		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	14											0						ACCTCGGGAACTTCTGGAAGG	0.706													T	53103406	T	T	53103406	2	4	94	1	0	0	0	0	0	0	0	1	12241	564	20	3		3	POM121L12	7	53103406	Silent	SNP	C	TCGA-06-5418-01A-01D-1486-08	7385758	53103406	106035257	28	6293											
FKBP6	8468	broad.mit.edu	37	chr7	72744235	72744235	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctgttcaaaccgaactaCgcctatggaacgctgggctg	10	11	2	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr7:72744235C>T	uc003tya.2	+	4	480	c.348C>T	c.(346-348)TAC>TAT	p.Y116Y	FKBP6_uc003twz.2_Intron|FKBP6_uc011kew.1_Silent_p.Y111Y|FKBP6_uc010lbe.1_RNA|TRIM50_uc003txy.1_5'Flank|TRIM50_uc003txz.1_5'Flank	NM_003602	NP_003593	O75344	FKBP6_HUMAN	FK506 binding protein 6 isoform a	116	PPIase FKBP-type.				protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				AACCGAACTACGCCTATGGAA	0.537													T	72744235	T	T	72744235	2	4	94	1	0	0	0	0	0	0	0	1	5912	547	19	1		1	FKBP6	7	72744235	Silent	SNP	C	TCGA-06-5418-01A-01D-1486-08	19640829	72744235	86394428	29	6294											
MUC17	140453	broad.mit.edu	37	chr7	100680821	100680821	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacctcaactcctagtgaaCggaccactccattagcaggt	7	13	1	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr7:100680821C>T	uc003uxp.1	+	3	6177	c.6124C>T	c.(6124-6126)CGG>TGG	p.R2042W	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2042	Extracellular (Potential).|32.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCTAGTGAACGGACCACTCC	0.502													T	100680821	T	T	100680821	3	4	94	1	0	0	0	0	1	0	0	0	9974	527	19	1	6134	1	MUC17	7	100680821	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	27936586	100680821	58457842	30	6295											
PIK3CG	5294	broad.mit.edu	37	chr7	106508855	106508855	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggatgagtacctggtgggCgaaacgcccatcaaaaactt	12	10	1	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr7:106508855C>T	uc003vdv.3	+	2	934	c.849C>T	c.(847-849)GGC>GGT	p.G283G	PIK3CG_uc003vdu.2_Silent_p.G283G|PIK3CG_uc003vdw.2_Silent_p.G283G	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	283					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						ACCTGGTGGGCGAAACGCCCA	0.552													T	106508855	T	T	106508855	2	4	94	1	0	0	0	0	0	0	0	1	11916	755	27	1		1	PIK3CG	7	106508855	Silent	SNP	C	TCGA-06-5418-01A-01D-1486-08	5828034	106508855	52629808	31	6296											
PTDSS1	9791	broad.mit.edu	37	chr8	97345772	97345772	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcattccaagtcaaaagtcaCcaatggcgttggaaagaaat	9	8	2	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr8:97345772C>G	uc003yht.1	+	13	1502	c.1400C>G	c.(1399-1401)ACC>AGC	p.T467S	PTDSS1_uc003yhu.1_Missense_Mutation_p.T321S	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	467					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TCAAAAGTCACCAATGGCGTT	0.473											OREG0018880	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	97345772	G	G	97345772	3	3	94	1	0	0	0	0	1	0	0	0	12736	507	18	5	1450	5	PTDSS1	8	97345772	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08		97345772	49018250	32	6297											
ACTL7B	10880	broad.mit.edu	37	chr9	111617172	111617172	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcggggaagccatccagcaTagtgcagccgccacacagta	11	14	0	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr9:111617172T>C	uc004bdi.2	-	1	1104	c.1039A>G	c.(1039-1041)ATG>GTG	p.M347V		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	347						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						CCATCCAGCATAGTGCAGCCG	0.682													C	111617172	C	C	111617172	3	2	94	1	0	0	0	0	1	0	0	0	201	1406	49	4	212	4	ACTL7B	9	111617172	Missense_Mutation	SNP	T	TCGA-06-5418-01A-01D-1486-08		111617172	29596259	33	6298											
ZNF618	114991	broad.mit.edu	37	chr9	116798608	116798608	+	Frame_Shift_Del	DEL	C	-	-													acctgcggcgcctgtgggatCcagttccagttctacaacaa							TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr9:116798608delC	uc004bid.2	+	13	1296	c.1197delC	c.(1195-1197)ATCfs	p.I399fs	ZNF618_uc004bic.2_Frame_Shift_Del_p.I306fs|ZNF618_uc011lxi.1_Frame_Shift_Del_p.I366fs|ZNF618_uc011lxj.1_Frame_Shift_Del_p.I367fs|ZNF618_uc010mvb.2_5'UTR	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	399	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCTGTGGGATCCAGTTCCAGT	0.582													-	116798608	-	-	116798608	7	5	94	1	0	1	0	1	0	0	0	0	18039	845	30	0	964	0	ZNF618	9	116798608	Frame_Shift_Del	DEL	C	TCGA-06-5418-01A-01D-1486-08	5181436	116798608	24414823	34	6299											
SCAI	286205	broad.mit.edu	37	chr9	127781214	127781214	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggtattatcatcatttaatAccattacaggatccgcctaa	5	9	2	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr9:127781214A>G	uc004bpe.2	-	9	806	c.725T>C	c.(724-726)GTA>GCA	p.V242A	SCAI_uc004bpd.2_Missense_Mutation_p.V265A|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	242					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						ATCATTTAATACCATTACAGG	0.393													G	127781214	G	G	127781214	3	3	94	1	0	0	0	0	1	0	0	0	13869	391	14	4	1135	4	SCAI	9	127781214	Missense_Mutation	SNP	A	TCGA-06-5418-01A-01D-1486-08	10982606	127781214	13432217	35	6300											
LAMC3	10319	broad.mit.edu	37	chr9	133943586	133943586	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agccgctgctaccctggcttCttcgacctccagcctgggag	11	16	1	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr9:133943586C>T	uc004caa.1	+	15	2813	c.2715C>T	c.(2713-2715)TTC>TTT	p.F905F		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	905	Laminin EGF-like 9.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		ACCCTGGCTTCTTCGACCTCC	0.667													T	133943586	T	T	133943586	2	4	94	1	0	0	0	0	0	0	0	1	8616	912	32	3		3	LAMC3	9	133943586	Silent	SNP	C	TCGA-06-5418-01A-01D-1486-08	6162372	133943586	7269845	36	6301											
COL5A1	1289	broad.mit.edu	37	chr9	137623922	137623922	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttatcacccccagattggAggacctcggggcgagaaagg	13	10	1	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr9:137623922A>G	uc004cfe.2	+	9	1720	c.1338A>G	c.(1336-1338)GGA>GGG	p.G446G		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	446	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCCAGATTGGAGGACCTCGGG	0.532													G	137623922	G	G	137623922	2	3	94	1	0	0	0	0	0	0	0	1	3696	291	11	4		4	COL5A1	9	137623922	Silent	SNP	A	TCGA-06-5418-01A-01D-1486-08	3680336	137623922	3589509	37	6302											
ADARB2	105	broad.mit.edu	37	chr10	1284215	1284215	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaggtgcagctccagctgcGtgtagaggaagtgcaggaac	15	9	1	1			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr10:1284215G>A	uc009xhq.2	-	5	1714	c.1340C>T	c.(1339-1341)ACG>ATG	p.T447M		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	447	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CTCCAGCTGCGTGTAGAGGAA	0.701													A	1284215	A	A	1284215	3	1	94	1	0	0	0	0	1	0	0	0	283	1145	40	1	903	1	ADARB2	10	1284215	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08		1284215	134250532	38	6303											
PFKFB3	5209	broad.mit.edu	37	chr10	6265943	6265943	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagatgccctacctgaaatgCcctcttcacaccgtcctgaa	7	15	2	3			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr10:6265943C>T	uc001ije.2	+	12	1620	c.1236C>T	c.(1234-1236)TGC>TGT	p.C412C	PFKFB3_uc001ijd.2_Silent_p.C392C|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Silent_p.C426C|PFKFB3_uc001ijf.2_Silent_p.C412C|PFKFB3_uc001ijg.2_5'Flank|PFKFB3_uc009xij.2_5'Flank|PFKFB3_uc009xik.2_5'Flank|PFKFB3_uc009xil.2_5'Flank	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	412	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						ACCTGAAATGCCCTCTTCACA	0.423													T	6265943	T	T	6265943	2	4	94	1	0	0	0	0	0	0	0	1	11762	747	26	3		3	PFKFB3	10	6265943	Silent	SNP	C	TCGA-06-5418-01A-01D-1486-08	4981728	6265943	129268804	39	6304											
PTEN	5728	broad.mit.edu	37	chr10	89711993	89711993	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgatgtttgaaactattcCaatgttcagtggcggaactt	10	6	1	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr10:89711993C>T	uc001kfb.2	+	7	1642	c.611C>T	c.(610-612)CCA>CTA	p.P204L		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	204	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(3)|p.G165fs*9(3)|p.P204T(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G165_K342del(1)|p.G165_*404del(1)|p.P204S(1)|p.P204fs*17(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GAAACTATTCCAATGTTCAGT	0.358		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89711993	T	T	89711993	3	4	94	1	0	0	0	0	1	0	0	0	12738	594	21	3	633	3	PTEN	10	89711993	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08	83446050	89711993	45822754	40	6305											
DCLRE1A	9937	broad.mit.edu	37	chr10	115610208	115610208	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaaccgagttatcagttTggttctgatacgaagaccat	9	7	2	3			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr10:115610208T>C	uc001law.2	-	2	1574	c.656A>G	c.(655-657)CAA>CGA	p.Q219R		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	219					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		GTTATCAGTTTGGTTCTGATA	0.433								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					C	115610208	C	C	115610208	3	2	94	1	0	0	0	0	1	0	0	0	4294	1812	63	4	2498	4	DCLRE1A	10	115610208	Missense_Mutation	SNP	T	TCGA-06-5418-01A-01D-1486-08	25898215	115610208	19924539	41	6306											
METTL12	751071	broad.mit.edu	37	chr11	62434124	62434124	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatgtgctgggggtggacttTtctcctgtggctgtggccca	16	9	1	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr11:62434124T>C	uc001nug.1	+	3	583	c.324T>C	c.(322-324)TTT>TTC	p.F108F	C11orf48_uc001nue.2_Intron|C11orf48_uc001nuf.2_Intron|METTL12_uc001nuh.2_Missense_Mutation_p.F150S|METTL12_uc010rmc.1_RNA	NM_001043229	NP_001036694	A8MUP2	MTL12_HUMAN	methyltransferase like 12 precursor	108						mitochondrion	methyltransferase activity				0						GGGTGGACTTTTCTCCTGTGG	0.592													C	62434124	C	C	62434124	2	2	94	1	0	0	0	0	0	0	0	1	9496	1838	64	4		4	METTL12	11	62434124	Silent	SNP	T	TCGA-06-5418-01A-01D-1486-08		62434124	72572392	42	6307											
AICDA	57379	broad.mit.edu	37	chr12	8758006	8758006	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggaggtgaaccaggtgaCgcggtagcagcggccagggt	18	10	0	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr12:8758006C>T	uc001qur.2	-	3	311	c.232G>A	c.(232-234)GTC>ATC	p.V78I	AICDA_uc001qup.1_Missense_Mutation_p.V73I|AICDA_uc001quq.1_Missense_Mutation_p.V73I|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	78					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					AACCAGGTGACGCGGTAGCAG	0.617									Immune_Deficiency_with_Hyper-IgM				T	8758006	T	T	8758006	3	4	94	1	0	0	0	0	1	0	0	0	422	536	19	1	376	1	AICDA	12	8758006	Missense_Mutation	SNP	C	TCGA-06-5418-01A-01D-1486-08		8758006	125093889	43	6308											
AGAP2	116986	broad.mit.edu	37	chr12	58120988	58120988	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtagctgctcgtacttggcGcgaatccacgactcgcgctc	11	14	0	0	rs145154021		TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr12:58120988G>A	uc001spq.2	-	18	3105	c.3105C>T	c.(3103-3105)CGC>CGT	p.R1035R	AGAP2_uc001spo.1_5'Flank|AGAP2_uc001spp.2_Silent_p.R1034R|AGAP2_uc001spr.2_Silent_p.R679R|LOC100130776_uc001sps.3_Silent_p.A71A	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	1035	Arf-GAP.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						CGTACTTGGCGCGAATCCACG	0.677											OREG0021951	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	58120988	A	A	58120988	2	1	94	1	0	0	0	0	0	0	0	1	368	1074	38	1		1	AGAP2	12	58120988	Silent	SNP	G	TCGA-06-5418-01A-01D-1486-08	49362982	58120988	75730907	44	6309											
USP15	9958	broad.mit.edu	37	chr12	62785633	62785634	+	Frame_Shift_Ins	INS	-	A	A													tggattgggatcctgatttgINSaaaaaaagatattttgatga							TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr12:62785633_62785634insA	uc001src.1	+	17	2280_2281	c.2271_2272insA	c.(2269-2274)TTGAAAfs	p.L757fs	USP15_uc001srb.1_Frame_Shift_Ins_p.L728fs	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	757_758					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		ATCCTGATTTGAAAAAAAGATA	0.277													A	62785634	A	A	62785633	7	5	94	1	0	1	1	0	0	0	0	0	17043	1281	45	0	2246	0	USP15	12	62785633	Frame_Shift_Ins	INS	-	TCGA-06-5418-01A-01D-1486-08	4664645	62785633	71066262	45	6310											
ZFHX3	463	broad.mit.edu	37	chr16	72832031	72832031	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctctctttggctctgagcccGagtcttcttgtactgaccca	8	14	4	2	rs144091993	byFrequency	TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr16:72832031G>A	uc002fck.2	-	9	5223	c.4550C>T	c.(4549-4551)TCG>TTG	p.S1517L	ZFHX3_uc002fcl.2_Missense_Mutation_p.S603L	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1517					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CTCTGAGCCCGAGTCTTCTTG	0.483													A	72832031	A	A	72832031	3	1	94	1	0	0	0	0	1	0	0	0	17631	1059	37	2	6569	2	ZFHX3	16	72832031	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08		72832031	17522722	46	6311											
GEMIN4	50628	broad.mit.edu	37	chr17	649261	649261	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tttgcctctagagtctggatGaagatcctcagactgaggtc	11	9	3	5			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr17:649261G>T	uc002frs.1	-	2	2141	c.2022C>A	c.(2020-2022)TTC>TTA	p.F674L		NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	674					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		GAGTCTGGATGAAGATCCTCA	0.537													T	649261	T	T	649261	3	4	94	1	0	0	0	0	1	0	0	0	6330	1281	45	5	1158	5	GEMIN4	17	649261	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08		649261	80545949	47	6312											
DNAH2	146754	broad.mit.edu	37	chr17	7702526	7702526	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagaacaacctgcacatcGtgctctgcctcagccccatg	8	16	2	1	rs147918283		TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr17:7702526G>A	uc002giu.1	+	55	8679	c.8665G>A	c.(8665-8667)GTG>ATG	p.V2889M		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2889	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCTGCACATCGTGCTCTGCCT	0.597													A	7702526	A	A	7702526	3	1	94	1	0	0	0	0	1	0	0	0	4602	1145	40	1	8883	1	DNAH2	17	7702526	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08	7053265	7702526	73492684	48	6313											
WNK4	65266	broad.mit.edu	37	chr17	40945618	40945618	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccctcgcaaggtatataaCgagttcattctgccttcgga	9	11	2	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr17:40945618C>T	uc002ibj.2	+	12	2187	c.2166C>T	c.(2164-2166)AAC>AAT	p.N722N	WNK4_uc010wgx.1_Silent_p.N386N|WNK4_uc002ibk.1_Silent_p.N494N|WNK4_uc010wgy.1_Silent_p.N66N	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	722					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		AGGTATATAACGAGTTCATTC	0.488													T	40945618	T	T	40945618	2	4	94	1	0	0	0	0	0	0	0	1	17377	535	19	1		1	WNK4	17	40945618	Silent	SNP	C	TCGA-06-5418-01A-01D-1486-08	33243092	40945618	40249592	49	6314											
TUBB4	10382	broad.mit.edu	37	chr19	6495886	6495886	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggtgcggaaacagatgtcGtagagtgcctcgttgtcgat	15	7	0	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr19:6495886G>A	uc002mfg.1	-	4	731	c.624C>T	c.(622-624)TAC>TAT	p.Y208Y	TUBB4_uc002mff.1_Silent_p.Y136Y|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	208					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		AACAGATGTCGTAGAGTGCCT	0.612													A	6495886	A	A	6495886	2	1	94	1	0	0	0	0	0	0	0	1	16755	1140	40	1		1	TUBB4	19	6495886	Silent	SNP	G	TCGA-06-5418-01A-01D-1486-08		6495886	52633097	50	6315											
KIF16B	55614	broad.mit.edu	37	chr20	16337074	16337074	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaggtcatctggatttgcGcccaaagagcgagaaaccat	10	10	3	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr20:16337074G>A	uc002wpg.1	-	23	3680	c.3522C>T	c.(3520-3522)GGC>GGT	p.G1174G	KIF16B_uc002wpe.1_Silent_p.G556G|KIF16B_uc002wpf.1_Intron|KIF16B_uc010gch.1_Silent_p.G1123G	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1174					cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CTGGATTTGCGCCCAAAGAGC	0.493													A	16337074	A	A	16337074	2	1	94	1	0	0	0	0	0	0	0	1	8278	1074	38	1		1	KIF16B	20	16337074	Silent	SNP	G	TCGA-06-5418-01A-01D-1486-08		16337074	46688446	51	6316											
PARD6B	84612	broad.mit.edu	37	chr20	49366651	49366651	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatcataacagtgagaccgGcaaaccagaggaataatgtt	9	8	2	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr20:49366651G>A	uc002xvo.2	+	3	988	c.745G>A	c.(745-747)GCA>ACA	p.A249T		NM_032521	NP_115910	Q9BYG5	PAR6B_HUMAN	PAR-6 beta	249	PDZ.|Interaction with PARD3 and CDC42 (By similarity).				axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			kidney(1)	1						AGTGAGACCGGCAAACCAGAG	0.448													A	49366651	A	A	49366651	3	1	94	1	0	0	0	0	1	0	0	0	11446	1203	42	3	755	3	PARD6B	20	49366651	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08	33029577	49366651	13658869	52	6317											
ITGB2	3689	broad.mit.edu	37	chr21	46311847	46311847	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctatgtccgtgaagcccagcGcccggatgacaaacgactgc	11	14	0	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr21:46311847G>A	uc002zgd.2	-	10	1333	c.1289C>T	c.(1288-1290)GCG>GTG	p.A430V	ITGB2_uc002zge.2_Missense_Mutation_p.A430V|ITGB2_uc002zgf.3_Missense_Mutation_p.A430V|ITGB2_uc011afl.1_Missense_Mutation_p.A352V|ITGB2_uc010gpw.2_Missense_Mutation_p.A373V|ITGB2_uc002zgg.2_Missense_Mutation_p.A430V	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	430	Extracellular (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GAAGCCCAGCGCCCGGATGAC	0.642													A	46311847	A	A	46311847	3	1	94	1	0	0	0	0	1	0	0	0	7894	1087	38	1	1044	1	ITGB2	21	46311847	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08		46311847	1818048	53	6318											
PCBP3	54039	broad.mit.edu	37	chr21	47355174	47355174	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggtatacccaggtctggaCgccagcccaccggccagcac	11	16	1	0			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chr21:47355174C>T	uc002zhq.1	+	12	989	c.864C>T	c.(862-864)GAC>GAT	p.D288D	PCBP3_uc010gqb.2_Silent_p.D288D|PCBP3_uc002zhp.1_Silent_p.D268D|PCBP3_uc002zhs.1_Silent_p.D262D|PCBP3_uc002zhr.1_Silent_p.D287D|PCBP3_uc002zht.1_Silent_p.D278D	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	288					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		CAGGTCTGGACGCCAGCCCAC	0.577													T	47355174	T	T	47355174	2	4	94	1	0	0	0	0	0	0	0	1	11502	535	19	1		1	PCBP3	21	47355174	Silent	SNP	C	TCGA-06-5418-01A-01D-1486-08	1043327	47355174	774721	54	6319											
IL3RA	3563	broad.mit.edu	37	chrX	1464293	1464293	+	Frame_Shift_Del	DEL	T	-	-													taacagaaatgtgaccgataTcgagtgtgttaaagacgccg							TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chrX:1464293delT	uc004cps.2	+	3	498	c.149delT	c.(148-150)ATCfs	p.I50fs	IL3RA_uc011mhd.1_Intron	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	50	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GTGACCGATATCGAGTGTGTT	0.348													-	1464293	-	-	1464293	7	5	94	1	0	1	0	1	0	0	0	0	7695	1435	50	0	155	0	IL3RA	23	1464293	Frame_Shift_Del	DEL	T	TCGA-06-5418-01A-01D-1486-08		1464293	153806267	55	6320											
PCDH19	57526	broad.mit.edu	37	chrX	99662549	99662551	+	In_Frame_Del	DEL	CAG	-	-													acaagctcactgttgactgaCagcaggttgatgaccggcgg							TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chrX:99662549_99662551delCAG	uc010nmz.2	-	1	2721_2723	c.1045_1047delCTG	c.(1045-1047)CTGdel	p.L349del	PCDH19_uc004efw.3_In_Frame_Del_p.L349del|PCDH19_uc004efx.3_In_Frame_Del_p.L349del	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	349	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						TGTTGACTGACAGCAGGTTGATG	0.616													-	99662551	-	-	99662549	7	5	94	1	0	1	0	1	0	0	0	0	11514	465	17	0	2423	0	PCDH19	23	99662549	In_Frame_Del	DEL	CAG	TCGA-06-5418-01A-01D-1486-08	98198256	99662549	55608011	56	6321											
TBC1D8B	54885	broad.mit.edu	37	chrX	106097468	106097468	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaagatatacatagtatgcGctgtcgaaataggttgtatg	11	4	0	2			TCGA-06-5418-01A-01D-1486-08	TCGA-06-5418-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ae28fd78-d254-46fa-aba1-1353931aa414	b22fa0ee-e512-4b27-84ce-10bc0af1dcab	g.chrX:106097468G>A	uc004emo.2	+	14	2459	c.2294G>A	c.(2293-2295)CGC>CAC	p.R765H	MORC4_uc004emp.3_Intron	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	765						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CATAGTATGCGCTGTCGAAAT	0.348													A	106097468	A	A	106097468	3	1	94	1	0	0	0	0	1	0	0	0	15623	1087	38	1	2414	1	TBC1D8B	23	106097468	Missense_Mutation	SNP	G	TCGA-06-5418-01A-01D-1486-08	6434919	106097468	49173092	57	6322											
ZMYM1	79830	broad.mit.edu	37	chr1	35580838	35580841	+	Frame_Shift_Del	DEL	TCAG	-	-													tgaaattgtggaaaagtttaTcagtcagatgaaagaaatat							TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr1:35580838_35580841delTCAG	uc001bym.2	+	11	3555_3558	c.3407_3410delTCAG	c.(3406-3411)ATCAGTfs	p.I1136fs	ZMYM1_uc001byn.2_Frame_Shift_Del_p.I1136fs|ZMYM1_uc010ohu.1_Frame_Shift_Del_p.I1117fs|ZMYM1_uc001byo.2_Frame_Shift_Del_p.I776fs|ZMYM1_uc009vut.2_Frame_Shift_Del_p.I1061fs	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	1136_1137						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GAAAAGTTTATCAGTCAGATGAAA	0.348													-	35580841	-	-	35580838	7	5	95	1	0	1	0	1	0	0	0	0	17696	1435	50	0	3441	0	ZMYM1	1	35580838	Frame_Shift_Del	DEL	TCAG	TCGA-06-5856-01A-01D-1696-08		35580838	213669783	1	6323											
GNG5	2787	broad.mit.edu	37	chr1	84967630	84967630	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ttctgcagacagaactgtttCaagtctgcagctgcctggga	11	10	3	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr1:84967630C>A	uc001djw.3	-	3	459	c.105G>T	c.(103-105)TTG>TTT	p.L35F		NM_005274	NP_005265	P63218	GBG5_HUMAN	guanine nucleotide binding protein (G protein),	35					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0				all cancers(265;0.00634)|Epithelial(280;0.0175)|OV - Ovarian serous cystadenocarcinoma(397;0.159)		AGAACTGTTTCAAGTCTGCAG	0.433													A	84967630	A	A	84967630	3	1	95	1	0	0	0	0	1	0	0	0	6530	825	29	5	105	5	GNG5	1	84967630	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	49386792	84967630	164282991	2	6324											
SPAG17	200162	broad.mit.edu	37	chr1	118539227	118539227	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tattattcttttacctggggAcatgttcaccatagatttgc	7	8	2	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr1:118539227A>T	uc001ehk.2	-	33	4984	c.4916T>A	c.(4915-4917)GTC>GAC	p.V1639D		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1639						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTACCTGGGGACATGTTCACC	0.299													T	118539227	T	T	118539227	3	4	95	1	0	0	0	0	1	0	0	0	14979	275	10	5	1819	5	SPAG17	1	118539227	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08	33571597	118539227	130711394	3	6325											
BCL9	607	broad.mit.edu	37	chr1	147092093	147092093	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcgggaacttgagtttgggaTggttcctagtgggatgaagg	17	4	0	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr1:147092093T>G	uc001epq.2	+	8	2872	c.2132T>G	c.(2131-2133)ATG>AGG	p.M711R	BCL9_uc010ozr.1_Missense_Mutation_p.M637R	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	711	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					GAGTTTGGGATGGTTCCTAGT	0.527			T	IGH@|IGL@	B-ALL								G	147092093	G	G	147092093	3	3	95	1	0	0	0	0	1	0	0	0	1381	1464	51	5	2150	5	BCL9	1	147092093	Missense_Mutation	SNP	T	TCGA-06-5856-01A-01D-1696-08	28552866	147092093	102158528	4	6326											
KPRP	448834	broad.mit.edu	37	chr1	152732521	152732521	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagaatgcccagtccagaacTatgtaccctgtccagctcct	7	14	0	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr1:152732521T>G	uc001fal.1	+	2	515	c.457T>G	c.(457-459)TAT>GAT	p.Y153D		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	153	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTCCAGAACTATGTACCCTG	0.512													G	152732521	G	G	152732521	3	3	95	1	0	0	0	0	1	0	0	0	8436	1522	53	5	459	5	KPRP	1	152732521	Missense_Mutation	SNP	T	TCGA-06-5856-01A-01D-1696-08	5640428	152732521	96518100	5	6327											
NPR1	4881	broad.mit.edu	37	chr1	153657481	153657481	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggcctcggagctgtggcGggtgcgctgggaggacgttg	20	9	0	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr1:153657481G>A	uc001fcs.3	+	8	1947	c.1526G>A	c.(1525-1527)CGG>CAG	p.R509Q	NPR1_uc010pdz.1_Missense_Mutation_p.R255Q|NPR1_uc010pea.1_Missense_Mutation_p.R13Q	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	509	Cytoplasmic (Potential).				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GAGCTGTGGCGGGTGCGCTGG	0.647													A	153657481	A	A	153657481	3	1	95	1	0	0	0	0	1	0	0	0	10594	1116	39	2	1556	2	NPR1	1	153657481	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08	924960	153657481	95593140	6	6328											
C1orf198	84886	broad.mit.edu	37	chr1	230979428	230979428	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcggcctcaggcccctccCctcgggaccgctcagcattg	10	19	2	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr1:230979428C>T	uc001hub.2	-	3	643	c.599G>A	c.(598-600)GGG>GAG	p.G200E	C1orf198_uc009xfh.1_Missense_Mutation_p.G70E|C1orf198_uc001huc.1_5'UTR|C1orf198_uc001hud.1_Missense_Mutation_p.G162E	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	200											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				AGGCCCCTCCCCTCGGGACCG	0.632													T	230979428	T	T	230979428	3	4	95	1	0	0	0	0	1	0	0	0	2026	623	22	3	392	3	C1orf198	1	230979428	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	77321947	230979428	18271193	7	6329											
OR2M3	127062	broad.mit.edu	37	chr1	248366725	248366725	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctttcttttggctgttatggCttatgaccgctacactgcca	8	11	1	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr1:248366725C>A	uc010pzg.1	+	1	356	c.356C>A	c.(355-357)GCT>GAT	p.A119D		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCTGTTATGGCTTATGACCGC	0.463													A	248366725	A	A	248366725	3	1	95	1	0	0	0	0	1	0	0	0	11011	797	28	5	358	5	OR2M3	1	248366725	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	17387297	248366725	883896	8	6330											
C2orf16	84226	broad.mit.edu	37	chr2	27799823	27799823	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccctagaccagggcatcaGtttgcaaaatatgcagagat	9	9	1	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr2:27799823G>A	uc002rkz.3	+	1	435	c.384G>A	c.(382-384)CAG>CAA	p.Q128Q		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	128										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CAGGGCATCAGTTTGCAAAAT	0.403													A	27799823	A	A	27799823	2	1	95	1	0	0	0	0	0	0	0	1	2157	1020	36	3		3	C2orf16	2	27799823	Silent	SNP	G	TCGA-06-5856-01A-01D-1696-08		27799823	215399550	9	6331											
MAP4K3	8491	broad.mit.edu	37	chr2	39560698	39560698	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcacatgaccattatccgtTaatagaatgttagctccctt	5	10	1	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr2:39560698T>G	uc002rro.2	-	7	523	c.432A>C	c.(430-432)TTA>TTC	p.L144F	MAP4K3_uc002rrp.2_Missense_Mutation_p.L144F	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	144	Protein kinase.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				CATTATCCGTTAATAGAATGT	0.269													G	39560698	G	G	39560698	3	3	95	1	0	0	0	0	1	0	0	0	9261	1751	61	5	2364	5	MAP4K3	2	39560698	Missense_Mutation	SNP	T	TCGA-06-5856-01A-01D-1696-08	11760875	39560698	203638675	10	6332											
BCL11A	53335	broad.mit.edu	37	chr2	60688972	60688972	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggattgcagaggagggagggGgggcgtcgccaggaagggcg	24	6	0	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr2:60688972G>C	uc002sae.1	-	4	1303	c.1075C>G	c.(1075-1077)CCC>GCC	p.P359A	BCL11A_uc002sab.2_Missense_Mutation_p.P359A|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Missense_Mutation_p.P325A|BCL11A_uc002sad.1_Missense_Mutation_p.P207A|BCL11A_uc002saf.1_Missense_Mutation_p.P325A	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	359	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GGAGGGAGGGGGGGCGTCGCC	0.632			T	IGH@	B-CLL								C	60688972	C	C	60688972	3	2	95	1	0	0	0	0	1	0	0	0	1363	1232	43	5	1542	5	BCL11A	2	60688972	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08	21128274	60688972	182510401	11	6333											
GPR45	11250	broad.mit.edu	37	chr2	105859160	105859160	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctccctctgctggctgcCccactccgtctacagcctcc	6	21	3	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr2:105859160C>T	uc002tco.1	+	1	961	c.845C>T	c.(844-846)CCC>CTC	p.P282L		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	282	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TGCTGGCTGCCCCACTCCGTC	0.592													T	105859160	T	T	105859160	3	4	95	1	0	0	0	0	1	0	0	0	6696	623	22	3	847	3	GPR45	2	105859160	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	45170188	105859160	137340213	12	6334											
PRRT3	285368	broad.mit.edu	37	chr3	9989638	9989638	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgagggggcctggactggggGtgctgggggatggctttggg	24	6	0	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr3:9989638G>A	uc003bul.2	-	4	1349	c.1219C>T	c.(1219-1221)CCC>TCC	p.P407S	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	407	Extracellular (Potential).|Pro-rich.					integral to membrane					0						TGGACTGGGGGTGCTGGGGGA	0.607													A	9989638	A	A	9989638	3	1	95	1	0	0	0	0	1	0	0	0	12611	1261	44	3	1730	3	PRRT3	3	9989638	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08		9989638	188032792	13	6335											
MUC7	4589	broad.mit.edu	37	chr4	71346565	71346565	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actacgtcacagaaggcatcAtcaccaatcacccaaatctc	4	15	5	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr4:71346565A>G	uc011cat.1	+	4	392	c.104A>G	c.(103-105)CAT>CGT	p.H35R	MUC7_uc011cau.1_Missense_Mutation_p.H35R|MUC7_uc003hfj.2_Missense_Mutation_p.H35R|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	35						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			AGAAGGCATCATCACCAATCA	0.318													G	71346565	G	G	71346565	3	3	95	1	0	0	0	0	1	0	0	0	9981	217	8	4	110	4	MUC7	4	71346565	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08		71346565	119807711	14	6336											
RASGEF1B	153020	broad.mit.edu	37	chr4	82380500	82380500	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	acctacatctggatagtaatCcacattaggtactaagtgct	7	9	1	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr4:82380500C>A	uc003hmi.1	-	2	307	c.163G>T	c.(163-165)GAT>TAT	p.D55Y	RASGEF1B_uc003hmj.1_Missense_Mutation_p.D55Y|RASGEF1B_uc010ijq.1_Missense_Mutation_p.D55Y|RASGEF1B_uc003hmk.2_Missense_Mutation_p.D55Y	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	55	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						GGATAGTAATCCACATTAGGT	0.443													A	82380500	A	A	82380500	3	1	95	1	0	0	0	0	1	0	0	0	13070	855	30	5	1310	5	RASGEF1B	4	82380500	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	11033935	82380500	108773776	15	6337											
FNIP2	57600	broad.mit.edu	37	chr4	159790265	159790265	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggcacagcctcccacggtgCaggaggaacgggagggagga	19	10	0	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr4:159790265C>G	uc003iqe.3	+	13	2660	c.2477C>G	c.(2476-2478)GCA>GGA	p.A826G		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	826	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		TCCCACGGTGCAGGAGGAACG	0.607													G	159790265	G	G	159790265	3	3	95	1	0	0	0	0	1	0	0	0	5976	710	25	5	2527	5	FNIP2	4	159790265	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	77409765	159790265	31364011	16	6338											
NEK1	4750	broad.mit.edu	37	chr4	170345795	170345795	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gtggtaaatgcgagtgagatCgaaatgcaaaggattcttct	12	5	2	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr4:170345795C>A	uc003isb.1	-	29	3539	c.3047G>T	c.(3046-3048)CGA>CTA	p.R1016L	NEK1_uc003isc.1_Missense_Mutation_p.R972L|NEK1_uc003isd.1_Missense_Mutation_p.R1044L|NEK1_uc003ise.1_Missense_Mutation_p.R1000L|NEK1_uc003isf.1_Missense_Mutation_p.R947L	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1016					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		CGAGTGAGATCGAAATGCAAA	0.398													A	170345795	A	A	170345795	3	1	95	1	0	0	0	0	1	0	0	0	10321	884	31	5	753	5	NEK1	4	170345795	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	10555530	170345795	20808481	17	6339											
SLC9A3	6550	broad.mit.edu	37	chr5	481703	481703	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctctgagataattgtgcccGatctgtccggatatgtcctc	9	11	2	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr5:481703G>A	uc003jbe.2	-	9	1606	c.1494C>T	c.(1492-1494)ATC>ATT	p.I498I	SLC9A3_uc011clx.1_Silent_p.I489I	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	498	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AATTGTGCCCGATCTGTCCGG	0.582													A	481703	A	A	481703	2	1	95	1	0	0	0	0	0	0	0	1	14713	1048	37	2		2	SLC9A3	5	481703	Silent	SNP	G	TCGA-06-5856-01A-01D-1696-08		481703	180433557	18	6340											
NSUN2	54888	broad.mit.edu	37	chr5	6600309	6600309	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggcctttccccgccatccGcataagacgatgggacactg	11	14	0	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr5:6600309G>A	uc003jdu.2	-	19	2099	c.2034C>T	c.(2032-2034)TGC>TGT	p.C678C	NSUN2_uc003jds.2_Silent_p.C124C|NSUN2_uc003jdt.2_Silent_p.C442C|NSUN2_uc011cmk.1_Silent_p.C643C|NSUN2_uc003jdv.2_Silent_p.C442C	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	678						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						CCCGCCATCCGCATAAGACGA	0.458													A	6600309	A	A	6600309	2	1	95	1	0	0	0	0	0	0	0	1	10678	1079	38	1		1	NSUN2	5	6600309	Silent	SNP	G	TCGA-06-5856-01A-01D-1696-08	6118606	6600309	174314951	19	6341											
MYO10	4651	broad.mit.edu	37	chr5	16668401	16668401	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cttacctcactggtttcaaaGagcagctccctctcatcgac	6	15	3	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr5:16668401G>A	uc003jft.3	-	40	6528	c.6060C>T	c.(6058-6060)CTC>CTT	p.L2020L	MYO10_uc011cnb.1_Silent_p.L649L|MYO10_uc011cnc.1_Silent_p.L899L|MYO10_uc011cnd.1_Silent_p.L1377L|MYO10_uc011cne.1_Silent_p.L1377L|MYO10_uc010itx.2_Silent_p.L1642L	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	2020	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TGGTTTCAAAGAGCAGCTCCC	0.463													A	16668401	A	A	16668401	2	1	95	1	0	0	0	0	0	0	0	1	10062	929	33	3		3	MYO10	5	16668401	Silent	SNP	G	TCGA-06-5856-01A-01D-1696-08	10068092	16668401	164246859	20	6342											
HIST1H2AA	221613	broad.mit.edu	37	chr6	25726579	25726579	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	agctcaaggatttctgctgtGagatactctaacactgccgc	9	11	3	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr6:25726579G>T	uc003nfc.2	-	1	212	c.177C>A	c.(175-177)CTC>CTA	p.L59L	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	59					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TTTCTGCTGTGAGATACTCTA	0.537													T	25726579	T	T	25726579	2	4	95	1	0	0	0	0	0	0	0	1	7128	1277	45	5		5	HIST1H2AA	6	25726579	Silent	SNP	G	TCGA-06-5856-01A-01D-1696-08		25726579	145388488	21	6343											
PSMB8	5696	broad.mit.edu	37	chr6	32811722	32811722	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttcccgcaaccgggagagCcgattccggccgctgccctc	12	18	0	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr6:32811722C>T	uc003oce.2	-	1	95	c.52G>A	c.(52-54)GCT>ACT	p.A18T	PSMB8_uc003ocf.2_Intron|PSMB8_uc011dqh.1_Missense_Mutation_p.A18T	NM_148919	NP_683720	P28062	PSB8_HUMAN	proteasome beta 8 subunit isoform E2 proprotein	18					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			skin(1)	1						ACCGGGAGAGCCGATTCCGGC	0.637													T	32811722	T	T	32811722	3	4	95	1	0	0	0	0	1	0	0	0	12683	739	26	3	802	3	PSMB8	6	32811722	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	7085143	32811722	138303345	22	6344											
SCUBE3	222663	broad.mit.edu	37	chr6	35210070	35210072	+	In_Frame_Del	DEL	GAG	-	-													tgcgaaacaaaggcaaaacaGaggaggctggcagaatcaca							TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr6:35210070_35210072delGAG	uc003okf.1	+	13	1513_1515	c.1507_1509delGAG	c.(1507-1509)GAGdel	p.E504del	SCUBE3_uc003okg.1_In_Frame_Del_p.E503del|SCUBE3_uc003okh.1_In_Frame_Del_p.E391del	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	504					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						AGGCAAAACAGAGGAGGCTGGCA	0.547													-	35210072	-	-	35210070	7	5	95	1	0	1	0	1	0	0	0	0	13946	943	33	0	1557	0	SCUBE3	6	35210070	In_Frame_Del	DEL	GAG	TCGA-06-5856-01A-01D-1696-08	2398348	35210070	135904997	23	6345											
CPVL	54504	broad.mit.edu	37	chr7	29152433	29152433	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agggccgaccaaactcaattCtcttcctagtgggggaaaaa	10	10	2	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr7:29152433C>T	uc003szv.2	-	3	294	c.175G>A	c.(175-177)GAA>AAA	p.E59K	CPVL_uc003szw.2_Missense_Mutation_p.E59K|CPVL_uc003szx.2_Missense_Mutation_p.E59K	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	59					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						AAACTCAATTCTCTTCCTAGT	0.418													T	29152433	T	T	29152433	3	4	95	1	0	0	0	0	1	0	0	0	3835	922	32	3	1299	3	CPVL	7	29152433	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08		29152433	129986230	24	6346											
MYO1G	64005	broad.mit.edu	37	chr7	45016656	45016656	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccgatgtaggtgtagatgCggcccttctcgaacctggac	12	12	1	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr7:45016656C>T	uc003tmh.2	-	2	254	c.110G>A	c.(109-111)CGC>CAC	p.R37H	MYO1G_uc003tmg.2_5'Flank|MYO1G_uc010kym.2_Intron|MYO1G_uc003tmi.1_5'UTR|MYO1G_uc003tmj.2_5'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	37	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						GGTGTAGATGCGGCCCTTCTC	0.637													T	45016656	T	T	45016656	3	4	95	1	0	0	0	0	1	0	0	0	10074	768	27	1	3030	1	MYO1G	7	45016656	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	15864223	45016656	114122007	25	6347											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	95	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	10205166	55221822	103916841	26	6348											
POM121	9883	broad.mit.edu	37	chr7	72413475	72413475	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgaggggcagccaccgggGgccgccaagccggcccttgc	17	16	0	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr7:72413475G>A	uc003twk.2	+	11	2943	c.2943G>A	c.(2941-2943)GGG>GGA	p.G981G	POM121_uc003twj.2_Silent_p.G716G|POM121_uc010lam.1_Silent_p.G716G	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	981	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				AGCCACCGGGGGCCGCCAAGC	0.652													A	72413475	A	A	72413475	2	1	95	1	0	0	0	0	0	0	0	1	12239	1219	43	3		3	POM121	7	72413475	Silent	SNP	G	TCGA-06-5856-01A-01D-1696-08	17191653	72413475	86725188	27	6349											
ZC3HAV1L	92092	broad.mit.edu	37	chr7	138719356	138719356	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggttttcattgagaccaaaaAgtccatggcttttcaggacc	9	9	2	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr7:138719356A>G	uc003vum.1	-	2	446	c.434T>C	c.(433-435)CTT>CCT	p.L145P		NM_080660	NP_542391	Q96H79	ZCCHL_HUMAN	zinc finger CCCH-type, antiviral 1-like	145											0						GAGACCAAAAAGTCCATGGCT	0.483													G	138719356	G	G	138719356	3	3	95	1	0	0	0	0	1	0	0	0	17573	72	3	4	484	4	ZC3HAV1L	7	138719356	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08	66305881	138719356	20419307	28	6350											
RP1L1	94137	broad.mit.edu	37	chr8	10467546	10467546	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcaatttcctctaactgCgcctcttcttcttgctgtcc	4	15	6	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr8:10467546C>T	uc003wtc.2	-	4	4291	c.4062G>A	c.(4060-4062)GCG>GCA	p.A1354A		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1354					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		cctctaactgcgcctcttctt	0.179													T	10467546	T	T	10467546	2	4	95	1	0	0	0	0	0	0	0	1	13533	755	27	1		1	RP1L1	8	10467546	Silent	SNP	C	TCGA-06-5856-01A-01D-1696-08		10467546	135896476	29	6351											
CDC37L1	55664	broad.mit.edu	37	chr9	4679887	4679887	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgctgcccgcagctgccaggCggcggcgcccaggtgagaag	17	15	0	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr9:4679887C>G	uc003zio.2	+	1	330	c.120C>G	c.(118-120)GGC>GGG	p.G40G		NM_017913	NP_060383	Q7L3B6	CD37L_HUMAN	cell division cycle 37 homolog (S.	40	Self-association.					cytoplasm					0	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)		AGCTGCCAGGCGGCGGCGCCC	0.682											OREG0019085	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	4679887	G	G	4679887	2	3	95	1	0	0	0	0	0	0	0	1	3069	755	27	5		5	CDC37L1	9	4679887	Silent	SNP	C	TCGA-06-5856-01A-01D-1696-08		4679887	136533544	30	6352											
KIAA2026	158358	broad.mit.edu	37	chr9	5922764	5922764	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ctttacagagctattttgaaGatctattggcaaccactggc	8	9	1	3			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr9:5922764G>T	uc003zjq.3	-	8	3448	c.3232C>A	c.(3232-3234)CTT>ATT	p.L1078I	KIAA2026_uc010mht.2_Missense_Mutation_p.L253I	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1078										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CTATTTTGAAGATCTATTGGC	0.418													T	5922764	T	T	5922764	3	4	95	1	0	0	0	0	1	0	0	0	8270	942	33	5	3083	5	KIAA2026	9	5922764	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08	1242877	5922764	135290667	31	6353											
C9orf131	138724	broad.mit.edu	37	chr9	35044886	35044886	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtctacccaagggagtaacgTgcccaggggttaaggcagag	15	9	1	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr9:35044886T>C	uc003zvw.2	+	2	2289	c.2260T>C	c.(2260-2262)TGC>CGC	p.C754R	C9orf131_uc003zvu.2_Missense_Mutation_p.C706R|C9orf131_uc003zvv.2_Missense_Mutation_p.C681R|C9orf131_uc003zvx.2_Missense_Mutation_p.C719R	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	754											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			GGGAGTAACGTGCCCAGGGGT	0.587													C	35044886	C	C	35044886	3	2	95	1	0	0	0	0	1	0	0	0	2457	1696	59	4	2282	4	C9orf131	9	35044886	Missense_Mutation	SNP	T	TCGA-06-5856-01A-01D-1696-08	29122122	35044886	106168545	32	6354											
FBP1	2203	broad.mit.edu	37	chr9	97380079	97380079	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgccaaaaatggttccaaCggacacaaggcaatcgatgt	10	9	0	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr9:97380079C>T	uc004auw.3	-	3	728	c.397G>A	c.(397-399)GTT>ATT	p.V133I	FBP1_uc010mrl.2_Missense_Mutation_p.V133I	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	133					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	ATGGTTCCAACGGACACAAGG	0.388													T	97380079	T	T	97380079	3	4	95	1	0	0	0	0	1	0	0	0	5705	536	19	1	639	1	FBP1	9	97380079	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	62335193	97380079	43833352	33	6355											
CDHR1	92211	broad.mit.edu	37	chr10	85962739	85962739	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctccgattcttctgcaggatGgcggtgggaggcttcatggg	16	9	3	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr10:85962739G>T	uc001kcv.2	+	8	643	c.643G>T	c.(643-645)GGC>TGC	p.G215C	CDHR1_uc001kcw.2_Missense_Mutation_p.G215C|CDHR1_uc009xst.2_5'UTR	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	215	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						TCTGCAGGATGGCGGTGGGAG	0.393													T	85962739	T	T	85962739	3	4	95	1	0	0	0	0	1	0	0	0	3118	1348	47	5	673	5	CDHR1	10	85962739	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08		85962739	49572008	34	6356											
AHNAK	79026	broad.mit.edu	37	chr11	62286891	62286891	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gttcagctctgcctcaggaaCagtgacatccagtgaaggtg	12	10	3	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr11:62286891C>G	uc001ntl.2	-	5	15298	c.14998G>C	c.(14998-15000)GTT>CTT	p.V5000L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5000					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GCCTCAGGAACAGTGACATCC	0.433													G	62286891	G	G	62286891	3	3	95	1	0	0	0	0	1	0	0	0	414	478	17	5	2794	5	AHNAK	11	62286891	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08		62286891	72719625	35	6357											
MTMR2	8898	broad.mit.edu	37	chr11	95580911	95580911	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccaatgagtagattccaaGttagacaaccagtgggtttc	10	8	0	3			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr11:95580911G>A	uc001pfu.2	-	10	1399	c.1146C>T	c.(1144-1146)AAC>AAT	p.N382N	MTMR2_uc001pfv.2_Silent_p.N310N|MTMR2_uc001pfs.2_Silent_p.N310N|MTMR2_uc001pft.2_Silent_p.N310N|MTMR2_uc010ruj.1_Silent_p.N365N	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	382	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TAGATTCCAAGTTAGACAACC	0.368													A	95580911	A	A	95580911	2	1	95	1	0	0	0	0	0	0	0	1	9944	1020	36	3		3	MTMR2	11	95580911	Silent	SNP	G	TCGA-06-5856-01A-01D-1696-08	33294020	95580911	39425605	36	6358											
SCN3B	55800	broad.mit.edu	37	chr11	123513193	123513193	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggggatcagccgcgtcgtctTcacaaagggccgatgcgcct	14	13	3	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr11:123513193T>C	uc001pza.1	-	4	813	c.406A>G	c.(406-408)AAG>GAG	p.K136E	SCN3B_uc001pzb.1_Missense_Mutation_p.K136E	NM_001040151	NP_001035241	Q9NY72	SCN3B_HUMAN	voltage-gated sodium channel beta-3 subunit	136	Ig-like C2-type.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		CGCGTCGTCTTCACAAAGGGC	0.592													C	123513193	C	C	123513193	3	2	95	1	0	0	0	0	1	0	0	0	13919	1792	62	4	253	4	SCN3B	11	123513193	Missense_Mutation	SNP	T	TCGA-06-5856-01A-01D-1696-08	27932282	123513193	11493323	37	6359											
EFCAB4B	84766	broad.mit.edu	37	chr12	3788105	3788105	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaacaccttttgggctccaAgtctgtccatcagcatccgg	8	15	2	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:3788105A>G	uc001qmj.2	-	6	1072	c.500T>C	c.(499-501)CTT>CCT	p.L167P	EFCAB4B_uc010sen.1_Missense_Mutation_p.L167P|EFCAB4B_uc010seo.1_Missense_Mutation_p.L167P	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	167					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TTGGGCTCCAAGTCTGTCCAT	0.517													G	3788105	G	G	3788105	3	3	95	1	0	0	0	0	1	0	0	0	4937	72	3	4	1947	4	EFCAB4B	12	3788105	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08		3788105	130063790	38	6360											
NDUFA9	4704	broad.mit.edu	37	chr12	4771765	4771765	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcgtaaagccgtcggacatcTttggaagagaggatagattc	12	7	1	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:4771765T>C	uc001qnc.2	+	6	629	c.619T>C	c.(619-621)TTT>CTT	p.F207L	NDUFA9_uc009zei.1_Missense_Mutation_p.F207L|NDUFA9_uc010ses.1_5'UTR	NM_005002	NP_004993	Q16795	NDUA9_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	207					mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	GTCGGACATCTTTGGAAGAGA	0.393													C	4771765	C	C	4771765	3	2	95	1	0	0	0	0	1	0	0	0	10272	1609	56	4	641	4	NDUFA9	12	4771765	Missense_Mutation	SNP	T	TCGA-06-5856-01A-01D-1696-08	983660	4771765	129080130	39	6361											
PLEKHA5	54477	broad.mit.edu	37	chr12	19285373	19285373	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tatacttttgaaggtgcaagAtactatataaagtgagtttt	8	3	0	3			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:19285373A>T	uc001reb.2	+	3	302	c.216A>T	c.(214-216)AGA>AGT	p.R72S	PLEKHA5_uc010sie.1_Missense_Mutation_p.R72S|PLEKHA5_uc001rea.2_Missense_Mutation_p.R72S|PLEKHA5_uc009zin.2_5'UTR|PLEKHA5_uc001rdz.3_Missense_Mutation_p.R72S	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	72	WW 2.						1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					AAGGTGCAAGATACTATATAA	0.313													T	19285373	T	T	19285373	3	4	95	1	0	0	0	0	1	0	0	0	12059	330	12	5	226	5	PLEKHA5	12	19285373	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08	14513608	19285373	114566522	40	6362											
H3F3C	440093	broad.mit.edu	37	chr12	31944878	31944878	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcagtgttgaaatcctgcgCgatctccctcaccaacctct	7	15	4	1	rs141415515		TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:31944878C>T	uc001rkr.2	-	1	298	c.223G>A	c.(223-225)GCG>ACG	p.A75T		NM_001013699	NP_001013721	Q6NXT2	H3C_HUMAN	histone H3-like	75					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AAATCCTGCGCGATCTCCCTC	0.587										HNSCC(67;0.2)			T	31944878	T	T	31944878	3	4	95	1	0	0	0	0	1	0	0	0	6935	768	27	1	188	1	H3F3C	12	31944878	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	12659505	31944878	101907017	41	6363											
OR6C75	390323	broad.mit.edu	37	chr12	55759176	55759176	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaaccatttcttataatggGtgtgtggctcagctattttt	9	6	2	1	rs113253007		TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:55759176G>T	uc010spk.1	+	1	282	c.282G>T	c.(280-282)GGG>GGT	p.G94G		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						CTTATAATGGGTGTGTGGCTC	0.448													T	55759176	T	T	55759176	2	4	95	1	0	0	0	0	0	0	0	1	11199	1248	44	5		5	OR6C75	12	55759176	Silent	SNP	G	TCGA-06-5856-01A-01D-1696-08	23814298	55759176	78092719	42	6364											
SMARCC2	6601	broad.mit.edu	37	chr12	56578637	56578637	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	agaccatttacctggtgtctCttgataatgtcctttaattt	6	8	1	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:56578637C>G	uc001skb.2	-	5	589	c.483G>C	c.(481-483)AAG>AAC	p.K161N	SMARCC2_uc001skd.2_Missense_Mutation_p.K161N|SMARCC2_uc001ska.2_Missense_Mutation_p.K161N|SMARCC2_uc001skc.2_Missense_Mutation_p.K161N|SMARCC2_uc010sqf.1_Missense_Mutation_p.K50N	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	161					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			CCTGGTGTCTCTTGATAATGT	0.418													G	56578637	G	G	56578637	3	3	95	1	0	0	0	0	1	0	0	0	14776	912	32	5	3354	5	SMARCC2	12	56578637	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	819461	56578637	77273258	43	6365											
MARCH9	92979	broad.mit.edu	37	chr12	58152353	58152353	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tcctattgctcaggcctcatCatccatgaaggctcctctgt	7	14	4	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:58152353C>A	uc001spx.1	+	4	1126	c.714C>A	c.(712-714)ATC>ATA	p.I238I	MARCH9_uc001spy.2_Silent_p.I125I	NM_138396	NP_612405	Q86YJ5	MARH9_HUMAN	membrane-associated RING-CH protein IX	238	Helical; (Potential).					Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding				0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CAGGCCTCATCATCCATGAAG	0.478													A	58152353	A	A	58152353	2	1	95	1	0	0	0	0	0	0	0	1	9308	816	29	5		5	MARCH9	12	58152353	Silent	SNP	C	TCGA-06-5856-01A-01D-1696-08	1573716	58152353	75699542	44	6366											
IFNG	3458	broad.mit.edu	37	chr12	68552011	68552011	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcctaagaaaagagttccaTtatccgctacatctgaatga	7	9	1	4			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:68552011T>C	uc001stw.1	-	2	269	c.143A>G	c.(142-144)AAT>AGT	p.N48S		NM_000619	NP_000610	P01579	IFNG_HUMAN	interferon, gamma precursor	48					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	AAGAGTTCCATTATCCGCTAC	0.308													C	68552011	C	C	68552011	3	2	95	1	0	0	0	0	1	0	0	0	7548	1493	52	4	369	4	IFNG	12	68552011	Missense_Mutation	SNP	T	TCGA-06-5856-01A-01D-1696-08	10399658	68552011	65299884	45	6367											
CNOT2	4848	broad.mit.edu	37	chr12	70732228	70732228	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tttttttcatgctagaatttGaatacatctggcaagacaac	6	7	2	3			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:70732228G>C	uc001svv.2	+	10	1485	c.906G>C	c.(904-906)TTG>TTC	p.L302F	CNOT2_uc009zro.2_Missense_Mutation_p.L302F|CNOT2_uc009zrp.2_Missense_Mutation_p.L282F|CNOT2_uc009zrq.2_Missense_Mutation_p.L302F|CNOT2_uc001svw.1_Missense_Mutation_p.L42F	NM_014515	NP_055330	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	302					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity				0	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			GCTAGAATTTGAATACATCTG	0.294													C	70732228	C	C	70732228	3	2	95	1	0	0	0	0	1	0	0	0	3619	1281	45	5	940	5	CNOT2	12	70732228	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08	2180217	70732228	63119667	46	6368											
CNOT2	4848	broad.mit.edu	37	chr12	70732315	70732315	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acacaaaataataaccagcaGaaaaaagggatccaggtgtt	8	7	0	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr12:70732315G>C	uc001svv.2	+	10	1572	c.993G>C	c.(991-993)CAG>CAC	p.Q331H	CNOT2_uc009zro.2_Missense_Mutation_p.Q331H|CNOT2_uc009zrp.2_Missense_Mutation_p.Q311H|CNOT2_uc009zrq.2_Missense_Mutation_p.Q331H|CNOT2_uc001svw.1_Missense_Mutation_p.Q71H	NM_014515	NP_055330	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	331					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity				0	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			ATAACCAGCAGAAAAAAGGGA	0.338													C	70732315	C	C	70732315	3	2	95	1	0	0	0	0	1	0	0	0	3619	933	33	5	1027	5	CNOT2	12	70732315	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08	87	70732315	63119580	47	6369											
FSCB	84075	broad.mit.edu	37	chr14	44974567	44974567	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctcagatagtggagactgagCttcagcaggagtttcatctg	12	8	4	3			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr14:44974567C>A	uc001wvn.2	-	1	1933	c.1624G>T	c.(1624-1626)GCT>TCT	p.A542S		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	542	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		GGAGACTGAGCTTCAGCAGGA	0.493													A	44974567	A	A	44974567	3	1	95	1	0	0	0	0	1	0	0	0	6066	797	28	5	857	5	FSCB	14	44974567	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08		44974567	62374973	48	6370											
ACTN1	87	broad.mit.edu	37	chr14	69349203	69349203	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggtctggatccagggcccgAtgacattggcctgggctcca	14	12	1	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr14:69349203A>C	uc001xkl.2	-	16	2235	c.1925T>G	c.(1924-1926)ATC>AGC	p.I642S	ACTN1_uc001xkk.2_Missense_Mutation_p.I238S|ACTN1_uc010ttb.1_Missense_Mutation_p.I577S|ACTN1_uc001xkm.2_Missense_Mutation_p.I642S|ACTN1_uc001xkn.2_Missense_Mutation_p.I642S|ACTN1_uc010ttc.1_Missense_Mutation_p.I227S	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	642	Spectrin 4.|Interaction with DDN.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CCAGGGCCCGATGACATTGGC	0.642													C	69349203	C	C	69349203	3	2	95	1	0	0	0	0	1	0	0	0	204	333	12	5	847	5	ACTN1	14	69349203	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08	24374636	69349203	38000337	49	6371											
ACOT4	122970	broad.mit.edu	37	chr14	74060458	74060458	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tttggtattggagggggcctCttggaatatcgagccagcct	14	8	1	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr14:74060458C>A	uc001xoo.2	+	2	764	c.510C>A	c.(508-510)CTC>CTA	p.L170L		NM_152331	NP_689544	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	170					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)		GAGGGGGCCTCTTGGAATATC	0.423													A	74060458	A	A	74060458	2	1	95	1	0	0	0	0	0	0	0	1	153	900	32	5		5	ACOT4	14	74060458	Silent	SNP	C	TCGA-06-5856-01A-01D-1696-08	4711255	74060458	33289082	50	6372											
MAPKBP1	23005	broad.mit.edu	37	chr15	42107465	42107465	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcctcttcaggtctacccCgaggtgaaggatagtaacca	11	12	3	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr15:42107465C>T	uc001zok.3	+	12	1483	c.1197C>T	c.(1195-1197)CCC>CCT	p.P399P	MAPKBP1_uc001zoj.3_Silent_p.P393P|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Silent_p.P393P|MAPKBP1_uc010udb.1_Intron|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	399	WD 6.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AGGTCTACCCCGAGGTGAAGG	0.572													T	42107465	T	T	42107465	2	4	95	1	0	0	0	0	0	0	0	1	9292	639	23	2		2	MAPKBP1	15	42107465	Silent	SNP	C	TCGA-06-5856-01A-01D-1696-08		42107465	60423927	51	6373											
CAMKK1	84254	broad.mit.edu	37	chr17	3772866	3772866	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgctgcagtgctcctcctccGaaggaaggggctcctccccg	12	17	0	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr17:3772866G>A	uc002fwt.2	-	14	1350	c.1256C>T	c.(1255-1257)TCG>TTG	p.S419L	CAMKK1_uc002fwu.2_Missense_Mutation_p.S419L|CAMKK1_uc002fwv.2_Missense_Mutation_p.S457L	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	419					synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		CTCCTCCTCCGAAGGAAGGGG	0.632													A	3772866	A	A	3772866	3	1	95	1	0	0	0	0	1	0	0	0	2606	1059	37	2	277	2	CAMKK1	17	3772866	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08		3772866	77422344	52	6374											
MED13	9969	broad.mit.edu	37	chr17	60061549	60061549	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tacccctctttgatgaatggCattgaaggccctgaagaaag	10	9	1	5			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr17:60061549C>A	uc002izo.2	-	15	2948	c.2871G>T	c.(2869-2871)ATG>ATT	p.M957I		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	957					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TGATGAATGGCATTGAAGGCC	0.378													A	60061549	A	A	60061549	3	1	95	1	0	0	0	0	1	0	0	0	9430	710	25	5	3717	5	MED13	17	60061549	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	56288683	60061549	21133661	53	6375											
CBX8	57332	broad.mit.edu	37	chr17	77769275	77769275	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggaggccaggtcctggggcGagcggccagggtaggggatc	21	9	0	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr17:77769275G>A	uc002jxd.1	-	5	422	c.329C>T	c.(328-330)TCG>TTG	p.S110L		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	110					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GTCCTGGGGCGAGCGGCCAGG	0.657													A	77769275	A	A	77769275	3	1	95	1	0	0	0	0	1	0	0	0	2724	1045	37	2	819	2	CBX8	17	77769275	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08	17707726	77769275	3425935	54	6376											
INO80C	125476	broad.mit.edu	37	chr18	33077703	33077703	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgcaaagctggaagcggAcgcttttttcttcttactgg	11	10	2	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr18:33077703A>T	uc002kyy.3	-	1	253	c.136T>A	c.(136-138)TCC>ACC	p.S46T	INO80C_uc002kyw.1_Missense_Mutation_p.S46T|INO80C_uc002kyx.3_5'Flank|INO80C_uc010dmt.2_Missense_Mutation_p.S46T	NM_194281	NP_919257	Q6PI98	IN80C_HUMAN	Ies6-similar protein isoform 2	46					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|MLL1 complex					0						CTGGAAGCGGACGCTTTTTTC	0.672													T	33077703	T	T	33077703	3	4	95	1	0	0	0	0	1	0	0	0	7748	275	10	5	578	5	INO80C	18	33077703	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08		33077703	44999545	55	6377											
POLI	11201	broad.mit.edu	37	chr18	51820790	51820790	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtacaaaaggaactgctgGcagagtggaagagagcagga	15	6	0	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr18:51820790G>A	uc002lfj.3	+	10	2244	c.2176G>A	c.(2176-2178)GCA>ACA	p.A726T	POLI_uc010xds.1_Missense_Mutation_p.A647T|POLI_uc002lfk.3_Missense_Mutation_p.A623T|POLI_uc010dpg.2_Missense_Mutation_p.A322T	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	726					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		GGAACTGCTGGCAGAGTGGAA	0.388								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					A	51820790	A	A	51820790	3	1	95	1	0	0	0	0	1	0	0	0	12203	1203	42	3	2214	3	POLI	18	51820790	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08	18743087	51820790	26256458	56	6378											
DUS3L	56931	broad.mit.edu	37	chr19	5790075	5790075	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcctggattagggagggacAcagcctgttcttgtcgtagt	14	8	1	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr19:5790075A>C	uc002mdc.2	-	2	467	c.370T>G	c.(370-372)TGT>GGT	p.C124G	DUS3L_uc002mdd.2_Intron|DUS3L_uc010duk.2_5'UTR|DUS3L_uc010xiw.1_Intron	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	124	C3H1-type 1.				tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						AGGGAGGGACACAGCCTGTTC	0.607													C	5790075	C	C	5790075	3	2	95	1	0	0	0	0	1	0	0	0	4807	159	6	5	1630	5	DUS3L	19	5790075	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08		5790075	53338908	57	6379											
ADAMTS10	81794	broad.mit.edu	37	chr19	8651442	8651442	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcccccagtctccctgttacCatgacgatgagagatgcatt	9	13	1	3			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr19:8651442C>A	uc002mkj.1	-	20	2677	c.2403G>T	c.(2401-2403)ATG>ATT	p.M801I	ADAMTS10_uc002mki.1_Missense_Mutation_p.M288I|ADAMTS10_uc002mkk.1_Missense_Mutation_p.M433I	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	801	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TCCCTGTTACCATGACGATGA	0.597											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	8651442	A	A	8651442	3	1	95	1	0	0	0	0	1	0	0	0	256	608	21	5	936	5	ADAMTS10	19	8651442	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	2861367	8651442	50477541	58	6380											
CDC37	11140	broad.mit.edu	37	chr19	10506731	10506731	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gctgctgtgcctcggcctgcAggcgctccagctctgccttg	13	16	1	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr19:10506731A>T	uc002mof.1	-	2	367	c.251T>A	c.(250-252)CTG>CAG	p.L84Q	CDC37_uc002moe.1_5'Flank|CDC37_uc010dxf.1_5'UTR|CDC37_uc002mog.1_Missense_Mutation_p.L84Q|CDC37_uc002moh.2_Missense_Mutation_p.L84Q	NM_007065	NP_008996	Q16543	CDC37_HUMAN	cell division cycle 37 protein	84					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		CTCGGCCTGCAGGCGCTCCAG	0.662													T	10506731	T	T	10506731	3	4	95	1	0	0	0	0	1	0	0	0	3068	188	7	5	913	5	CDC37	19	10506731	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08	1855289	10506731	48622252	59	6381											
CC2D1A	54862	broad.mit.edu	37	chr19	14029731	14029731	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctgtccggcccagaggtgcCcccacccccgaggaccctgc	11	21	0	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr19:14029731C>A	uc002mxo.2	+	10	1324	c.1025C>A	c.(1024-1026)CCC>CAC	p.P342H	CC2D1A_uc002mxn.2_Missense_Mutation_p.P241H|CC2D1A_uc002mxp.2_Missense_Mutation_p.P342H|CC2D1A_uc010dzh.2_5'UTR|CC2D1A_uc002mxq.1_5'UTR	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	342	Pro-rich.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			CCAGAGGTGCCCCCACCCCCG	0.672													A	14029731	A	A	14029731	3	1	95	1	0	0	0	0	1	0	0	0	2726	623	22	5	1063	5	CC2D1A	19	14029731	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	3523000	14029731	45099252	60	6382											
MYO9B	4650	broad.mit.edu	37	chr19	17212559	17212559	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggcaggcagctcgggccGccgggagcaggcggcctacc	18	14	0	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr19:17212559G>A	uc010eak.2	+	2	184	c.32G>A	c.(31-33)CGC>CAC	p.R11H	MYO9B_uc002nfi.2_Missense_Mutation_p.R11H|MYO9B_uc002nfj.1_Missense_Mutation_p.R11H	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	11	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						AGCTCGGGCCGCCGGGAGCAG	0.692													A	17212559	A	A	17212559	3	1	95	1	0	0	0	0	1	0	0	0	10085	1087	38	1	34	1	MYO9B	19	17212559	Missense_Mutation	SNP	G	TCGA-06-5856-01A-01D-1696-08	3182828	17212559	41916424	61	6383											
HCK	3055	broad.mit.edu	37	chr20	30661155	30661155	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acaacagcaacacaccaggaAtcagggagggtaagtatcta	10	9	2	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr20:30661155A>T	uc002wxh.2	+	3	388	c.217A>T	c.(217-219)ATC>TTC	p.I73F	HCK_uc010gdy.2_Missense_Mutation_p.I52F|HCK_uc002wxi.2_Missense_Mutation_p.I52F	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	73					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CACACCAGGAATCAGGGAGGG	0.468													T	30661155	T	T	30661155	3	4	95	1	0	0	0	0	1	0	0	0	6994	101	4	5	233	5	HCK	20	30661155	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08		30661155	32364365	62	6384											
R3HDML	140902	broad.mit.edu	37	chr20	42973947	42973947	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggctgtgccatccacacCtgtagtagcatcagtgtctg	11	12	2	0			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr20:42973947C>T	uc002xls.1	+	4	730	c.558C>T	c.(556-558)ACC>ACT	p.T186T		NM_178491	NP_848586	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like precursor	186						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CCATCCACACCTGTAGTAGCA	0.582													T	42973947	T	T	42973947	2	4	95	1	0	0	0	0	0	0	0	1	12889	668	24	3		3	R3HDML	20	42973947	Silent	SNP	C	TCGA-06-5856-01A-01D-1696-08	12312792	42973947	20051573	63	6385											
SEMG2	6407	broad.mit.edu	37	chr20	43851147	43851147	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatatcatacccgtcttcaCgtacagaagaaagacaactt	5	10	3	3	rs140069155		TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr20:43851147C>T	uc010ggz.2	+	2	931	c.874C>T	c.(874-876)CGT>TGT	p.R292C	SEMG2_uc002xnk.2_Missense_Mutation_p.R292C|SEMG2_uc002xnl.2_Missense_Mutation_p.R292C	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	292	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CCCGTCTTCACGTACAGAAGA	0.393													T	43851147	T	T	43851147	3	4	95	1	0	0	0	0	1	0	0	0	14045	536	19	1	880	1	SEMG2	20	43851147	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	877200	43851147	19174373	64	6386											
LZTR1	8216	broad.mit.edu	37	chr22	21349003	21349003	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagtgccgcccggctgcagcTgagccaactcaaggtgtggg	16	12	1	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr22:21349003T>G	uc002zto.2	+	15	1875	c.1772T>G	c.(1771-1773)CTG>CGG	p.L591R	LZTR1_uc002ztn.2_Missense_Mutation_p.L550R|LZTR1_uc011ahy.1_Missense_Mutation_p.L572R|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	591					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CGGCTGCAGCTGAGCCAACTC	0.667													G	21349003	G	G	21349003	3	3	95	1	0	0	0	0	1	0	0	0	9137	1580	55	5	1830	5	LZTR1	22	21349003	Missense_Mutation	SNP	T	TCGA-06-5856-01A-01D-1696-08		21349003	29955563	65	6387											
PPIL2	23759	broad.mit.edu	37	chr22	22042378	22042378	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acagatccaagggggcgaccCcacaggcacaggcacgggta	14	13	0	1			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chr22:22042378C>A	uc010gtj.1	+	14	1120	c.1004C>A	c.(1003-1005)CCC>CAC	p.P335H	PPIL2_uc002zvh.3_Missense_Mutation_p.P335H|PPIL2_uc002zvi.3_Missense_Mutation_p.P335H|PPIL2_uc002zvg.3_Missense_Mutation_p.P335H|PPIL2_uc011aij.1_Missense_Mutation_p.P314H|PPIL2_uc002zvk.3_Missense_Mutation_p.P81H	NM_148175	NP_680480	Q13356	PPIL2_HUMAN	peptidylprolyl isomerase-like 2 isoform a	335	PPIase cyclophilin-type.				blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			ovary(2)	2	Colorectal(54;0.105)					GGGGGCGACCCCACAGGCACA	0.642													A	22042378	A	A	22042378	3	1	95	1	0	0	0	0	1	0	0	0	12327	623	22	5	1058	5	PPIL2	22	22042378	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	693375	22042378	29262188	66	6388											
ZFX	7543	broad.mit.edu	37	chrX	24229156	24229156	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaaatgcaccagtgtagacAttgtgactttaagattgcag	9	6	0	3			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chrX:24229156A>C	uc004dbf.2	+	9	2339	c.2081A>C	c.(2080-2082)CAT>CCT	p.H694P	ZFX_uc004dbe.2_3'UTR|ZFX_uc011mjv.1_Missense_Mutation_p.H733P|ZFX_uc010nfz.2_Missense_Mutation_p.H350P	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	694	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2						CAGTGTAGACATTGTGACTTT	0.433													C	24229156	C	C	24229156	3	2	95	1	0	0	0	0	1	0	0	0	17658	217	8	5	2166	5	ZFX	23	24229156	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08		24229156	131041404	67	6389											
HDAC6	10013	broad.mit.edu	37	chrX	48681101	48681101	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccctccttggagacccaccAcccctgctgaccctgccacg	7	21	0	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chrX:48681101A>C	uc011mmi.1	+	24	2504	c.2409A>C	c.(2407-2409)CCA>CCC	p.P803P	HDAC6_uc004dks.1_Silent_p.P803P|HDAC6_uc010nig.1_Silent_p.P651P|HDAC6_uc004dkt.1_Silent_p.P803P|HDAC6_uc011mmk.1_Silent_p.P784P|HDAC6_uc004dkv.1_Silent_p.P451P|HDAC6_uc004dkw.1_Silent_p.P451P|HDAC6_uc004dkx.1_Silent_p.P166P	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	803					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	GAGACCCACCACCCCTGCTGA	0.587													C	48681101	C	C	48681101	2	2	95	1	0	0	0	0	0	0	0	1	7011	146	6	5		5	HDAC6	23	48681101	Silent	SNP	A	TCGA-06-5856-01A-01D-1696-08	24451945	48681101	106589459	68	6390											
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011638	105011638	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccaaagagcttagctttaCcagtgatatttggtagtgaa	9	7	0	3			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chrX:105011638C>T	uc004elz.1	+	11	2801	c.2045C>T	c.(2044-2046)ACC>ATC	p.T682I		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	682	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						CTTAGCTTTACCAGTGATATT	0.393													T	105011638	T	T	105011638	3	4	95	1	0	0	0	0	1	0	0	0	7662	507	18	3	2083	3	IL1RAPL2	23	105011638	Missense_Mutation	SNP	C	TCGA-06-5856-01A-01D-1696-08	56330537	105011638	50258922	69	6391											
L1CAM	3897	broad.mit.edu	37	chrX	153141260	153141260	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcaggggctgcagaggaggAgaggccacacgtaccgcagc	18	11	0	2			TCGA-06-5856-01A-01D-1696-08	TCGA-06-5856-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0bd9b573-712b-4da1-9c33-7b7f43d4af31	3c9bd859-2b0c-44d7-bfb2-eea6ae9c4de9	g.chrX:153141260A>C	uc004fjb.2	-	1	140	c.32T>G	c.(31-33)CTC>CGC	p.L11R	L1CAM_uc004fjc.2_Missense_Mutation_p.L11R|L1CAM_uc010nuo.2_Missense_Mutation_p.L11R|L1CAM_uc004fje.1_Missense_Mutation_p.L11R	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	11					axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCAGAGGAGGAGAGGCCACAC	0.627											OREG0003586	type=REGULATORY REGION|Gene=L1CAM|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	C	153141260	C	C	153141260	3	2	95	1	0	0	0	0	1	0	0	0	8588	304	11	5	3853	5	L1CAM	23	153141260	Missense_Mutation	SNP	A	TCGA-06-5856-01A-01D-1696-08	48129622	153141260	2129300	70	6392											
NOC2L	26155	broad.mit.edu	37	chr1	887446	887446	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagggcttcgctggggcccGcagtgctcaggacccggcac	17	14	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:887446G>A	uc001abz.3	-	11	1324	c.1265C>T	c.(1264-1266)GCG>GTG	p.A422V	NOC2L_uc001aby.3_Missense_Mutation_p.A219V|NOC2L_uc009vjq.2_Missense_Mutation_p.A422V	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	422						nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GCTGGGGCCCGCAGTGCTCAG	0.592													A	887446	A	A	887446	3	1	96	1	0	0	0	0	1	0	0	0	10513	1087	38	1	1020	1	NOC2L	1	887446	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		887446	248363175	1	6393											
PRDM16	63976	broad.mit.edu	37	chr1	3328828	3328828	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgactgcaacgggcgccgcCggggactccatcaaggccat	13	15	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:3328828C>T	uc001akf.2	+	9	2147	c.2067C>T	c.(2065-2067)GCC>GCT	p.A689A	PRDM16_uc001akc.2_Silent_p.A689A|PRDM16_uc001akd.2_Silent_p.A689A|PRDM16_uc001ake.2_Silent_p.A689A|PRDM16_uc009vlh.2_Silent_p.A390A	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	689	Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CGGGCGCCGCCGGGGACTCCA	0.642			T	EVI1	MDS|AML								T	3328828	T	T	3328828	2	4	96	1	0	0	0	0	0	0	0	1	12457	639	23	2		2	PRDM16	1	3328828	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	2441382	3328828	245921793	2	6394											
GPR153	387509	broad.mit.edu	37	chr1	6314021	6314021	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgcccatggccacgctgccGcccaccagcagcaggaagca	11	18	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:6314021G>A	uc001amp.1	-	3	803	c.543C>T	c.(541-543)GGC>GGT	p.G181G		NM_207370	NP_997253	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	181	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		CCACGCTGCCGCCCACCAGCA	0.692													A	6314021	A	A	6314021	2	1	96	1	0	0	0	0	0	0	0	1	6659	1074	38	1		1	GPR153	1	6314021	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	2985193	6314021	242936600	3	6395											
CLCN6	1185	broad.mit.edu	37	chr1	11893604	11893605	+	Frame_Shift_Ins	INS	-	T	T													tgaattcaagtatcaagacaINStttttttgtcccaatgatac							TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:11893604_11893605insT	uc001ate.3	+	14	1394_1395	c.1281_1282insT	c.(1279-1284)ACATTTfs	p.T427fs	CLCN6_uc010oat.1_Frame_Shift_Ins_p.T143fs|CLCN6_uc010oau.1_Frame_Shift_Ins_p.T405fs	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	427_428					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GTATCAAGACATTTTTTTGTCC	0.455													T	11893605	T	T	11893604	7	5	96	1	0	1	1	0	0	0	0	0	3467	204	8	0	1345	0	CLCN6	1	11893604	Frame_Shift_Ins	INS	-	TCGA-06-5858-01A-01D-1696-08	5579583	11893604	237357017	4	6396											
DNAJC16	23341	broad.mit.edu	37	chr1	15870908	15870908	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcaggtgtaggaattggcGtggtccatgctgggtatgag	16	5	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:15870908G>A	uc001aws.2	+	5	709	c.589G>A	c.(589-591)GTG>ATG	p.V197M	DNAJC16_uc001awr.1_Missense_Mutation_p.V197M|DNAJC16_uc001awt.2_Translation_Start_Site	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	197	Cytoplasmic (Potential).|Thioredoxin.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AGGAATTGGCGTGGTCCATGC	0.463													A	15870908	A	A	15870908	3	1	96	1	0	0	0	0	1	0	0	0	4635	1145	40	1	603	1	DNAJC16	1	15870908	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	3977304	15870908	233379713	5	6397											
NUDC	10726	broad.mit.edu	37	chr1	27268025	27268025	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagagagcccggcaggaggcCgagcggcgggagaaggcgga	21	9	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:27268025C>T	uc001bng.1	+	3	353	c.237C>T	c.(235-237)GCC>GCT	p.A79A	NUDC_uc001bnh.1_Silent_p.A136A|NUDC_uc009vsq.1_Silent_p.A53A	NM_006600	NP_006591	Q9Y266	NUDC_HUMAN	nuclear distribution gene C homolog	79	Potential.				cell proliferation|cytokinesis|mitotic prometaphase|multicellular organismal development	cytosol|microtubule|nucleoplasm	protein binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;6.1e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.87e-29)|Colorectal(126;5.74e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000281)|STAD - Stomach adenocarcinoma(196;0.000604)|KIRC - Kidney renal clear cell carcinoma(1967;0.000739)|READ - Rectum adenocarcinoma(331;0.0421)		GGCAGGAGGCCGAGCGGCGGG	0.617													T	27268025	T	T	27268025	2	4	96	1	0	0	0	0	0	0	0	1	10721	639	23	2		2	NUDC	1	27268025	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	11397117	27268025	221982596	6	6398											
EPS15	2060	broad.mit.edu	37	chr1	51829678	51829678	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagagctcgatgtggctgaaCgaaaaggatcttcattgttg	12	7	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:51829678C>T	uc001csq.1	-	23	2311	c.2219G>A	c.(2218-2220)CGT>CAT	p.R740H	EPS15_uc009vyz.1_Missense_Mutation_p.R606H|EPS15_uc001csp.3_Missense_Mutation_p.R426H	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	740	15 X 3 AA repeats of D-P-F.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						TGTGGCTGAACGAAAAGGATC	0.388			T	MLL	ALL								T	51829678	T	T	51829678	3	4	96	1	0	0	0	0	1	0	0	0	5192	536	19	1	483	1	EPS15	1	51829678	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	24561653	51829678	197420943	7	6399											
C1orf103	55791	broad.mit.edu	37	chr1	111490908	111490908	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcttaggagttgggaaccGgtgacattagcttccccatt	11	10	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:111490908G>A	uc001eaa.2	-	4	2239	c.1983C>T	c.(1981-1983)ACC>ACT	p.T661T	C1orf103_uc001dzz.2_Silent_p.T125T|C1orf103_uc001eab.2_Silent_p.T125T|C1orf103_uc001eac.1_Silent_p.T124T	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	661					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		GTTGGGAACCGGTGACATTAG	0.368													A	111490908	A	A	111490908	2	1	96	1	0	0	0	0	0	0	0	1	1977	1103	39	2		2	C1orf103	1	111490908	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	59661230	111490908	137759713	8	6400											
DENND2D	79961	broad.mit.edu	37	chr1	111730833	111730833	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcacaaacttcttcacaaatCggcggttggtcttggaggtc	10	10	4	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:111730833C>T	uc001eak.1	-	11	1459	c.1259G>A	c.(1258-1260)CGA>CAA	p.R420Q	DENND2D_uc001eal.1_Missense_Mutation_p.R417Q	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	420	dDENN.									ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		CTTCACAAATCGGCGGTTGGT	0.498													T	111730833	T	T	111730833	3	4	96	1	0	0	0	0	1	0	0	0	4431	884	31	2	164	2	DENND2D	1	111730833	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	239925	111730833	137519788	9	6401											
VANGL1	81839	broad.mit.edu	37	chr1	116226676	116226676	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agaggccgaacatgaacggcGagtaaagaagcggaaagcaa	14	7	0	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:116226676G>A	uc001efv.1	+	6	1329	c.1058G>A	c.(1057-1059)CGA>CAA	p.R353Q	VANGL1_uc009wgy.1_Missense_Mutation_p.R351Q	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	353	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane	protein binding			central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CATGAACGGCGAGTAAAGAAG	0.438													A	116226676	A	A	116226676	3	1	96	1	0	0	0	0	1	0	0	0	17116	1058	37	2	1076	2	VANGL1	1	116226676	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	4495843	116226676	133023945	10	6402											
NOTCH2NL	388677	broad.mit.edu	37	chr1	145273241	145273241	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcgagacccctgtgagaagaAccgctgccagaatggtggga	14	10	0	4			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:145273241A>G	uc001emn.3	+	3	465	c.95A>G	c.(94-96)AAC>AGC	p.N32S	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Missense_Mutation_p.N32S|NOTCH2NL_uc001emo.2_Missense_Mutation_p.N32S|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	32	EGF-like 2.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						TGTGAGAAGAACCGCTGCCAG	0.532													G	145273241	G	G	145273241	3	3	96	1	0	0	0	0	1	0	0	0	10549	43	2	4	101	4	NOTCH2NL	1	145273241	Missense_Mutation	SNP	A	TCGA-06-5858-01A-01D-1696-08	29046565	145273241	103977380	11	6403											
CHD1L	9557	broad.mit.edu	37	chr1	146766154	146766154	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	taactggtatggtactgagcGacttattcggaaacatctgg	11	7	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:146766154G>A	uc001epm.3	+	22	2633	c.2570G>A	c.(2569-2571)CGA>CAA	p.R857Q	uc001epp.2_Intron|CHD1L_uc001epn.3_Missense_Mutation_p.R744Q|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.R763Q|CHD1L_uc010ozp.1_Missense_Mutation_p.R576Q|CHD1L_uc001epo.3_Missense_Mutation_p.R653Q|CHD1L_uc009wji.2_Missense_Mutation_p.R576Q	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	857	Macro.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					GGTACTGAGCGACTTATTCGG	0.423													A	146766154	A	A	146766154	3	1	96	1	0	0	0	0	1	0	0	0	3324	1058	37	2	2656	2	CHD1L	1	146766154	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	1492913	146766154	102484467	12	6404											
INSRR	3645	broad.mit.edu	37	chr1	156823811	156823811	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaggcagtgccacgtcacGcagatgtggcatctcaaaga	12	11	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:156823811G>A	uc010pht.1	-	2	624	c.370C>T	c.(370-372)CGT>TGT	p.R124C	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Missense_Mutation_p.R124C	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	124					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCACGTCACGCAGATGTGGC	0.622													A	156823811	A	A	156823811	3	1	96	1	0	0	0	0	1	0	0	0	7774	1087	38	1	3606	1	INSRR	1	156823811	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	10057657	156823811	92426810	13	6405											
CD84	8832	broad.mit.edu	37	chr1	160535290	160535290	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgcgtcttccatcctcagatCgctaatgaccagattgtagt	8	11	2	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:160535290C>T	uc001fwh.3	-	2	316	c.292G>A	c.(292-294)GAT>AAT	p.D98N	CD84_uc001fwf.3_Missense_Mutation_p.D98N|CD84_uc001fwg.3_Missense_Mutation_p.D98N|CD84_uc009wtn.2_Missense_Mutation_p.D98N|CD84_uc001fwi.3_Intron|CD84_uc001fwj.2_Missense_Mutation_p.D98N|CD84_uc001fwk.2_Missense_Mutation_p.D98N	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	98	Extracellular (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATCCTCAGATCGCTAATGACC	0.463													T	160535290	T	T	160535290	3	4	96	1	0	0	0	0	1	0	0	0	3042	884	31	2	773	2	CD84	1	160535290	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	3711479	160535290	88715331	14	6406											
BLZF1	8548	broad.mit.edu	37	chr1	169347745	169347745	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatacagtgtgatgtatggCgaagtaaattccttgcaagc	10	7	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:169347745C>T	uc001gfx.1	+	4	1083	c.646C>T	c.(646-648)CGA>TGA	p.R216*	BLZF1_uc001gfy.2_Nonsense_Mutation_p.R216*|BLZF1_uc009wvp.1_Nonsense_Mutation_p.R193*	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	216					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					TGATGTATGGCGAAGTAAATT	0.363													T	169347745	T	T	169347745	4	4	96	1	0	0	0	0	0	1	0	0	1453	760	27	1	656	1	BLZF1	1	169347745	Nonsense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	8812455	169347745	79902876	15	6407											
CENPF	1063	broad.mit.edu	37	chr1	214837072	214837072	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctgagggtcaagcgaggcCgacttgtccccagccccaaa	12	15	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:214837072C>T	uc001hkm.2	+	20	9454	c.9280C>T	c.(9280-9282)CGA>TGA	p.R3094*		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	3190					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CAAGCGAGGCCGACTTGTCCC	0.582													T	214837072	T	T	214837072	4	4	96	1	0	0	0	0	0	1	0	0	3231	644	23	2	9354	2	CENPF	1	214837072	Nonsense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	45489327	214837072	34413549	16	6408											
GNPAT	8443	broad.mit.edu	37	chr1	231401503	231401503	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctcgaagggacaagaagcCgctctgccaagacattgact	10	12	1	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:231401503C>T	uc001hup.3	+	6	948	c.742C>T	c.(742-744)CGC>TGC	p.R248C	GNPAT_uc009xfo.1_Missense_Mutation_p.R139C|GNPAT_uc009xfp.2_Missense_Mutation_p.R187C	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	248					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				GACAAGAAGCCGCTCTGCCAA	0.378													T	231401503	T	T	231401503	3	4	96	1	0	0	0	0	1	0	0	0	6541	652	23	2	764	2	GNPAT	1	231401503	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	16564431	231401503	17849118	17	6409											
RYR2	6262	broad.mit.edu	37	chr1	237729890	237729890	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagagccgaagtgtgcagcGgcaccggggaaaggttccga	16	11	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:237729890G>A	uc001hyl.1	+	28	3358	c.3238G>A	c.(3238-3240)GGC>AGC	p.G1080S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1080	Cytoplasmic (By similarity).|2.|B30.2/SPRY 2.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGTGTGCAGCGGCACCGGGGA	0.502													A	237729890	A	A	237729890	3	1	96	1	0	0	0	0	1	0	0	0	13769	1116	39	2	3348	2	RYR2	1	237729890	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	6328387	237729890	11520731	18	6410											
WDR64	128025	broad.mit.edu	37	chr1	241946599	241946599	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagcagctgctttcctggcGtgctcattctttggaaatta	9	10	2	0	rs141496101	by1000genomes	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr1:241946599G>A	uc001hzf.1	+	12	1403	c.1250G>A	c.(1249-1251)CGT>CAT	p.R417H	WDR64_uc001hzg.1_Missense_Mutation_p.R330H	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	864										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CTTTCCTGGCGTGCTCATTCT	0.373													A	241946599	A	A	241946599	3	1	96	1	0	0	0	0	1	0	0	0	17312	1145	40	1	2677	1	WDR64	1	241946599	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	4216709	241946599	7304022	19	6411											
ASAP2	8853	broad.mit.edu	37	chr2	9517083	9517083	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgcagtcagatccgtggatcGaacctctcttcacattgtag	9	11	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:9517083G>A	uc002qzh.2	+	18	2133	c.1793G>A	c.(1792-1794)CGA>CAA	p.R598Q	ASAP2_uc002qzi.2_Missense_Mutation_p.R598Q	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	598	ANK 1.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						TCCGTGGATCGAACCTCTCTT	0.448													A	9517083	A	A	9517083	3	1	96	1	0	0	0	0	1	0	0	0	1011	1058	37	2	1863	2	ASAP2	2	9517083	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		9517083	233682290	20	6412											
GALNT14	79623	broad.mit.edu	37	chr2	31167749	31167749	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctccgtggggtccaggcGccgagccttctgctctgggg	18	13	2	0	rs143143842	by1000genomes	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:31167749G>A	uc002rnr.2	-	8	1421	c.802C>T	c.(802-804)CGC>TGC	p.R268C	GALNT14_uc002rnq.2_Missense_Mutation_p.R248C|GALNT14_uc002rns.2_Missense_Mutation_p.R273C|GALNT14_uc010ymr.1_Missense_Mutation_p.R233C|GALNT14_uc010ezo.1_Missense_Mutation_p.R235C|GALNT14_uc010ezp.1_Intron	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	268	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GGGTCCAGGCGCCGAGCCTTC	0.587													A	31167749	A	A	31167749	3	1	96	1	0	0	0	0	1	0	0	0	6212	1087	38	1	888	1	GALNT14	2	31167749	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	21650666	31167749	212031624	21	6413											
ARHGAP25	9938	broad.mit.edu	37	chr2	69034467	69034467	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaaattcggcccccatctgGtgcccatcctggtggagaaa	11	12	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:69034467G>A	uc002seu.2	+	5	890	c.526G>A	c.(526-528)GTG>ATG	p.V176M	ARHGAP25_uc010yqk.1_Missense_Mutation_p.V151M|ARHGAP25_uc010fdg.2_Missense_Mutation_p.V177M|ARHGAP25_uc010yql.1_Missense_Mutation_p.V137M|ARHGAP25_uc002sev.2_Missense_Mutation_p.V170M|ARHGAP25_uc002sew.2_Missense_Mutation_p.V169M|ARHGAP25_uc002sex.2_Missense_Mutation_p.V170M|ARHGAP25_uc010fdh.1_RNA|ARHGAP25_uc002sey.2_Translation_Start_Site	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	176	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						CCCCCATCTGGTGCCCATCCT	0.562													A	69034467	A	A	69034467	3	1	96	1	0	0	0	0	1	0	0	0	874	1261	44	3	587	3	ARHGAP25	2	69034467	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	37866718	69034467	174164906	22	6414											
C2orf68	388969	broad.mit.edu	37	chr2	85836146	85836146	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcatgggtggatccagaggCgtgtgtgccgacaccttctc	14	12	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:85836146C>T	uc002sqc.2	-	4	495	c.423G>A	c.(421-423)ACG>ACA	p.T141T	USP39_uc002sqb.2_Intron	NM_001013649	NP_001013671	Q2NKX9	CB068_HUMAN	hypothetical protein LOC388969	141										central_nervous_system(1)	1						GATCCAGAGGCGTGTGTGCCG	0.572													T	85836146	T	T	85836146	2	4	96	1	0	0	0	0	0	0	0	1	2187	755	27	1		1	C2orf68	2	85836146	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	16801679	85836146	157363227	23	6415											
TBC1D8	11138	broad.mit.edu	37	chr2	101656773	101656773	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagcgaacagtccacaaccGcgtgcagcttctccttcctc	8	16	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:101656773G>A	uc010fiv.2	-	6	1033	c.902C>T	c.(901-903)GCG>GTG	p.A301V	TBC1D8_uc010yvw.1_Missense_Mutation_p.A316V|TBC1D8_uc002tau.3_Missense_Mutation_p.A58V	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	301	GRAM 2.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						GTCCACAACCGCGTGCAGCTT	0.577													A	101656773	A	A	101656773	3	1	96	1	0	0	0	0	1	0	0	0	15622	1087	38	1	2580	1	TBC1D8	2	101656773	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	15820627	101656773	141542600	24	6416											
TUBA3D	113457	broad.mit.edu	37	chr2	132238322	132238322	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggtgcccgactggatttaaGgtatgactgggtgatgtgga	16	5	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:132238322G>T	uc002tsu.3	+	4	1163	c.1056G>T	c.(1054-1056)AAG>AAT	p.K352N		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	352					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CTGGATTTAAGGTATGACTGG	0.552													T	132238322	T	T	132238322	3	4	96	1	0	0	0	0	1	0	0	0	16744	1014	35	5	1070	5	TUBA3D	2	132238322	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	30581549	132238322	110961051	25	6417											
TANC1	85461	broad.mit.edu	37	chr2	160074082	160074082	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcatggagctgctgtgtcgCggacaaacaggagaggggtt	18	7	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:160074082C>T	uc002uag.2	+	20	3593	c.3319C>T	c.(3319-3321)CGG>TGG	p.R1107W	TANC1_uc010zcm.1_Missense_Mutation_p.R1099W|TANC1_uc010fom.1_Missense_Mutation_p.R913W|TANC1_uc010fon.2_5'UTR	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1107	ANK 6.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TGCTGTGTCGCGGACAAACAG	0.597													T	160074082	T	T	160074082	3	4	96	1	0	0	0	0	1	0	0	0	15541	759	27	1	3389	1	TANC1	2	160074082	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	27835760	160074082	83125291	26	6418											
TTN	7273	broad.mit.edu	37	chr2	179396884	179396884	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgagcatgttttgagatttCgtattcttcctcaatttctg	7	7	3	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:179396884C>T	uc010zfg.1	-	307	96978	c.96754G>A	c.(96754-96756)GAA>AAA	p.E32252K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25947K|TTN_uc010zfi.1_Missense_Mutation_p.E25880K|TTN_uc010zfj.1_Missense_Mutation_p.E25755K|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33179							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGAGATTTCGTATTCTTCC	0.413													T	179396884	T	T	179396884	3	4	96	1	0	0	0	0	1	0	0	0	16732	893	31	2	3541	2	TTN	2	179396884	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	19322802	179396884	63802489	27	6419											
SPATS2L	26010	broad.mit.edu	37	chr2	201337625	201337625	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcctctgctgaatgcgcaCgcagcaacctctgggaaaca	10	14	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:201337625C>T	uc002uvn.3	+	12	1483	c.1131C>T	c.(1129-1131)CAC>CAT	p.H377H	SPATS2L_uc010fst.2_Silent_p.H377H|SPATS2L_uc002uvo.3_Silent_p.H317H|SPATS2L_uc002uvp.3_Silent_p.H377H|SPATS2L_uc002uvq.3_Silent_p.H308H|SPATS2L_uc002uvr.3_Silent_p.H377H|SPATS2L_uc010zhc.1_Silent_p.H407H	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	377						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						TGAATGCGCACGCAGCAACCT	0.483													T	201337625	T	T	201337625	2	4	96	1	0	0	0	0	0	0	0	1	15019	535	19	1		1	SPATS2L	2	201337625	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	21940741	201337625	41861748	28	6420											
PID1	55022	broad.mit.edu	37	chr2	230020577	230020577	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcatcagcggtgtggtcGtgcacagctcaatggcctcc	11	13	4	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:230020577G>A	uc002vpr.3	-	2	271	c.233C>T	c.(232-234)ACG>ATG	p.T78M	PID1_uc002vps.3_Missense_Mutation_p.T76M|PID1_uc002vpt.3_Missense_Mutation_p.T45M|PID1_uc002vpu.3_Intron	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	78						cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		CGGTGTGGTCGTGCACAGCTC	0.517													A	230020577	A	A	230020577	3	1	96	1	0	0	0	0	1	0	0	0	11882	1145	40	1	527	1	PID1	2	230020577	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	28682952	230020577	13178796	29	6421											
UGT1A9	54600	broad.mit.edu	37	chr2	234580843	234580843	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccctggaggatctggaccGggagttcaaggcttttgccc	13	11	2	0	rs148603525	by1000genomes	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:234580843G>A	uc002vus.2	+	1	300	c.263G>A	c.(262-264)CGG>CAG	p.R88Q	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Missense_Mutation_p.R88Q	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	88					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	GATCTGGACCGGGAGTTCAAG	0.408													A	234580843	A	A	234580843	3	1	96	1	0	0	0	0	1	0	0	0	16949	1116	39	2	265	2	UGT1A9	2	234580843	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	4560266	234580843	8618530	30	6422											
TRPM8	79054	broad.mit.edu	37	chr2	234851383	234851383	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacaccctcatcaggaattgCgatgctgaggtaccggtggg	14	10	2	1	rs147774253		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:234851383C>T	uc002vvh.2	+	6	730	c.690C>T	c.(688-690)TGC>TGT	p.C230C	TRPM8_uc010fyj.2_5'UTR|TRPM8_uc002vvi.3_Silent_p.C180C|TRPM8_uc002vvj.3_Silent_p.C153C	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	230	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TCAGGAATTGCGATGCTGAGG	0.562													T	234851383	T	T	234851383	2	4	96	1	0	0	0	0	0	0	0	1	16589	776	27	1		1	TRPM8	2	234851383	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	270540	234851383	8347990	31	6423											
KIF1A	547	broad.mit.edu	37	chr2	241728662	241728662	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccggcttactgaggtgtgCgaccagtaggagtagtcaaa	13	9	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr2:241728662C>T	uc002vzy.2	-	3	320	c.174G>A	c.(172-174)TCG>TCA	p.S58S	KIF1A_uc010fzk.2_Silent_p.S58S|KIF1A_uc002vzz.1_Silent_p.S58S	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	58	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CTGAGGTGTGCGACCAGTAGG	0.612													T	241728662	T	T	241728662	2	4	96	1	0	0	0	0	0	0	0	1	8283	755	27	1		1	KIF1A	2	241728662	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	6877279	241728662	1470711	32	6424											
IL5RA	3568	broad.mit.edu	37	chr3	3139680	3139680	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcctgggaaaccagcatgCgatatttctccccagtgtgt	10	11	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:3139680C>T	uc011ask.1	-	8	1227	c.583G>A	c.(583-585)GCA>ACA	p.A195T	IL5RA_uc010hbq.2_Missense_Mutation_p.A195T|IL5RA_uc010hbr.2_Intron|IL5RA_uc010hbs.2_Missense_Mutation_p.A195T|IL5RA_uc011asl.1_Missense_Mutation_p.A195T|IL5RA_uc011asm.1_Missense_Mutation_p.A195T|IL5RA_uc010hbt.2_Missense_Mutation_p.A195T|IL5RA_uc011asn.1_Missense_Mutation_p.A195T|IL5RA_uc010hbu.2_Missense_Mutation_p.A195T	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	195	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		AACCAGCATGCGATATTTCTC	0.483													T	3139680	T	T	3139680	3	4	96	1	0	0	0	0	1	0	0	0	7700	768	27	1	729	1	IL5RA	3	3139680	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08		3139680	194882750	33	6425											
SCN5A	6331	broad.mit.edu	37	chr3	38620857	38620857	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggggcctggggttccgcttTccactgctgccgccagtcgg	15	14	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:38620857T>C	uc003cio.2	-	18	3552	c.3358A>G	c.(3358-3360)AAA>GAA	p.K1120E	SCN5A_uc003cin.2_Missense_Mutation_p.K1119E|SCN5A_uc003cil.3_Missense_Mutation_p.K1120E|SCN5A_uc010hhi.2_Missense_Mutation_p.K1120E|SCN5A_uc010hhk.2_Missense_Mutation_p.K1119E|SCN5A_uc011ayr.1_Intron|SCN5A_uc010hhj.1_Missense_Mutation_p.K730E	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1120					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGTTCCGCTTTCCACTGCTGC	0.662													C	38620857	C	C	38620857	3	2	96	1	0	0	0	0	1	0	0	0	13922	1792	62	4	2736	4	SCN5A	3	38620857	Missense_Mutation	SNP	T	TCGA-06-5858-01A-01D-1696-08	35481177	38620857	159401573	34	6426											
TTC21A	199223	broad.mit.edu	37	chr3	39152446	39152446	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttcctctggctcataggcCgccatgacaaggccaaagag	10	12	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:39152446C>T	uc003cjc.2	+	4	550	c.373C>T	c.(373-375)CGC>TGC	p.R125C	TTC21A_uc003cja.2_Missense_Mutation_p.R125C|TTC21A_uc010hho.1_Missense_Mutation_p.R88C|TTC21A_uc003cjb.2_Intron|TTC21A_uc003cje.2_Missense_Mutation_p.R125C|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.R125C	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	125	TPR 2.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GCTCATAGGCCGCCATGACAA	0.502													T	39152446	T	T	39152446	3	4	96	1	0	0	0	0	1	0	0	0	16684	652	23	2	387	2	TTC21A	3	39152446	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	531589	39152446	158869984	35	6427											
NBEAL2	23218	broad.mit.edu	37	chr3	47040042	47040042	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtttatcttggatgctctgCgcacccactacaggtgaggc	11	11	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:47040042C>T	uc003cqp.2	+	22	3387	c.3208C>T	c.(3208-3210)CGC>TGC	p.R1070C	NBEAL2_uc010hjm.1_Missense_Mutation_p.R631C	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1070							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GGATGCTCTGCGCACCCACTA	0.612											OREG0015546	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	47040042	T	T	47040042	3	4	96	1	0	0	0	0	1	0	0	0	10189	768	27	1	3294	1	NBEAL2	3	47040042	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	7887596	47040042	150982388	36	6428											
NCKIPSD	51517	broad.mit.edu	37	chr3	48719898	48719898	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcagcagcatccaagtggtgGtcactggttgatgaggtcat	14	8	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:48719898G>C	uc003cun.2	-	3	463	c.369C>G	c.(367-369)GAC>GAG	p.D123E	NCKIPSD_uc003cum.2_Missense_Mutation_p.D123E|NCKIPSD_uc010hkh.1_Missense_Mutation_p.D123E	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	123					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCAAGTGGTGGTCACTGGTTG	0.592													C	48719898	C	C	48719898	3	2	96	1	0	0	0	0	1	0	0	0	10225	1252	44	5	1843	5	NCKIPSD	3	48719898	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	1679856	48719898	149302532	37	6429											
P4HTM	54681	broad.mit.edu	37	chr3	49043241	49043241	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgttttatttgaacaacGtcactggtgggggcgagact	13	7	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:49043241G>A	uc003cvg.2	+	7	1454	c.1105G>A	c.(1105-1107)GTC>ATC	p.V369I	P4HTM_uc003cvh.2_Missense_Mutation_p.V430I|WDR6_uc011bbx.1_5'Flank|WDR6_uc003cvj.2_5'Flank|WDR6_uc011bby.1_5'Flank|WDR6_uc010hkn.2_5'Flank|WDR6_uc011bbz.1_5'Flank	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	369	Lumenal (Potential).|Fe2OG dioxygenase.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	TTTGAACAACGTCACTGGTGG	0.542													A	49043241	A	A	49043241	3	1	96	1	0	0	0	0	1	0	0	0	11360	1145	40	1	1314	1	P4HTM	3	49043241	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	323343	49043241	148979189	38	6430											
TMF1	7110	broad.mit.edu	37	chr3	69097037	69097037	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtagtctcttgtctcgagctCgctgagctctcacttattac	8	12	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:69097037C>T	uc003dnn.2	-	2	1066	c.819G>A	c.(817-819)GCG>GCA	p.A273A	TMF1_uc011bfx.1_Silent_p.A273A	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	273					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		GTCTCGAGCTCGCTGAGCTCT	0.398													T	69097037	T	T	69097037	2	4	96	1	0	0	0	0	0	0	0	1	16225	871	31	2		2	TMF1	3	69097037	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	20053796	69097037	128925393	39	6431											
FILIP1L	11259	broad.mit.edu	37	chr3	99568062	99568062	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaccattgatgactgcacGttccagaggaatgaggctct	11	10	1	5			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:99568062G>A	uc003dtm.2	-	5	2921	c.2458C>T	c.(2458-2460)CGT>TGT	p.R820C	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.R820C|FILIP1L_uc010hpf.2_Missense_Mutation_p.R396C|FILIP1L_uc010hpg.2_Missense_Mutation_p.R580C|FILIP1L_uc003dtn.2_Missense_Mutation_p.R580C|FILIP1L_uc003dtp.1_Missense_Mutation_p.R580C	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	820						cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						ATGACTGCACGTTCCAGAGGA	0.438													A	99568062	A	A	99568062	3	1	96	1	0	0	0	0	1	0	0	0	5895	1145	40	1	978	1	FILIP1L	3	99568062	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	30471025	99568062	98454368	40	6432											
KALRN	8997	broad.mit.edu	37	chr3	124017688	124017688	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttattcctccagagccacacGgagatcggagtcagctacca	9	13	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:124017688G>A	uc003ehg.2	+	6	1141	c.1014G>A	c.(1012-1014)ACG>ACA	p.T338T	KALRN_uc010hrv.1_Silent_p.T338T|KALRN_uc003ehf.1_Silent_p.T338T|KALRN_uc011bjy.1_Silent_p.T338T	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	338	Spectrin 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGAGCCACACGGAGATCGGAG	0.512													A	124017688	A	A	124017688	2	1	96	1	0	0	0	0	0	0	0	1	7975	1103	39	2		2	KALRN	3	124017688	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	24449626	124017688	74004742	41	6433											
ZNF148	7707	broad.mit.edu	37	chr3	124951615	124951615	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctattgatgggcatggtgGcatagacctgcttgtctatg	13	7	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:124951615G>A	uc003ehx.3	-	9	2441	c.1955C>T	c.(1954-1956)GCC>GTC	p.A652V	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Missense_Mutation_p.A652V|ZNF148_uc010hsa.2_Missense_Mutation_p.A652V|ZNF148_uc003eia.3_Missense_Mutation_p.A652V|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	652					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						GGGCATGGTGGCATAGACCTG	0.443													A	124951615	A	A	124951615	3	1	96	1	0	0	0	0	1	0	0	0	17731	1203	42	3	433	3	ZNF148	3	124951615	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	933927	124951615	73070815	42	6434											
CCDC37	348807	broad.mit.edu	37	chr3	126153184	126153184	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acgtgccccaggtcaagatcGagcaggccgagagggcaaag	15	11	1	2	rs141942694	by1000genomes	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:126153184G>A	uc003eiu.1	+	15	1687	c.1588G>A	c.(1588-1590)GAG>AAG	p.E530K	CCDC37_uc010hsg.1_Missense_Mutation_p.E531K	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	530	Potential.									ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		GGTCAAGATCGAGCAGGCCGA	0.637													A	126153184	A	A	126153184	3	1	96	1	0	0	0	0	1	0	0	0	2809	1059	37	2	1642	2	CCDC37	3	126153184	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	1201569	126153184	71869246	43	6435											
IFT122	55764	broad.mit.edu	37	chr3	129195512	129195512	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctcaccccgcaggtggtcGgctgccaggacggcaccatt	12	16	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:129195512G>A	uc003emm.2	+	11	1221	c.1015G>A	c.(1015-1017)GGC>AGC	p.G339S	IFT122_uc003eml.2_Missense_Mutation_p.G390S|IFT122_uc003emn.2_Missense_Mutation_p.G280S|IFT122_uc003emo.2_Missense_Mutation_p.G228S|IFT122_uc003emp.2_Missense_Mutation_p.G189S|IFT122_uc010htc.2_Missense_Mutation_p.G331S|IFT122_uc011bky.1_Missense_Mutation_p.G130S|IFT122_uc003emq.2_Missense_Mutation_p.G179S|IFT122_uc003emr.2_Missense_Mutation_p.G130S|IFT122_uc011bla.1_Missense_Mutation_p.G130S|IFT122_uc011bkx.1_Missense_Mutation_p.G179S|IFT122_uc011bkz.1_RNA	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	339	WD 6.				camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						GCAGGTGGTCGGCTGCCAGGA	0.527													A	129195512	A	A	129195512	3	1	96	1	0	0	0	0	1	0	0	0	7555	1116	39	2	1214	2	IFT122	3	129195512	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	3042328	129195512	68826918	44	6436											
CEP63	80254	broad.mit.edu	37	chr3	134226076	134226076	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaaacttgcttgaaaatccGtgaacaggaacttaagagtc	9	7	0	4			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:134226076G>A	uc003eqo.1	+	4	619	c.170G>A	c.(169-171)CGT>CAT	p.R57H	CEP63_uc003eql.1_Missense_Mutation_p.R57H|CEP63_uc003eqm.2_Missense_Mutation_p.R57H|CEP63_uc003eqn.1_Missense_Mutation_p.R57H	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	57	Potential.				cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						TTGAAAATCCGTGAACAGGAA	0.368													A	134226076	A	A	134226076	3	1	96	1	0	0	0	0	1	0	0	0	3257	1145	40	1	176	1	CEP63	3	134226076	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	5030564	134226076	63796354	45	6437											
CPB1	1360	broad.mit.edu	37	chr3	148545842	148545842	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatcacattaacataatccGcgagttggccagcacgaccc	7	13	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:148545842G>A	uc003ewl.2	+	2	148	c.125G>A	c.(124-126)CGC>CAC	p.R42H		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	42					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			AACATAATCCGCGAGTTGGCC	0.363													A	148545842	A	A	148545842	3	1	96	1	0	0	0	0	1	0	0	0	3796	1087	38	1	131	1	CPB1	3	148545842	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	14319766	148545842	49476588	46	6438											
EPHB3	2049	broad.mit.edu	37	chr3	184298249	184298249	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgttgcggggcattgctgcCggcatgaagtacctgtccga	14	10	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:184298249C>T	uc003foz.2	+	12	2669	c.2232C>T	c.(2230-2232)GCC>GCT	p.A744A		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	744	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCATTGCTGCCGGCATGAAGT	0.572													T	184298249	T	T	184298249	2	4	96	1	0	0	0	0	0	0	0	1	5176	639	23	2		2	EPHB3	3	184298249	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	35752407	184298249	13724181	47	6439											
LIPH	200879	broad.mit.edu	37	chr3	185245282	185245282	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagcgttaccatcagtgtcGgaatggatgacatcaacaaa	11	8	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:185245282G>A	uc003fpm.2	-	4	728	c.618C>T	c.(616-618)TCC>TCT	p.S206S	LIPH_uc010hyh.2_Intron	NM_139248	NP_640341	Q8WWY8	LIPH_HUMAN	lipase, member H precursor	206					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			ovary(1)|pancreas(1)	2	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			CATCAGTGTCGGAATGGATGA	0.527													A	185245282	A	A	185245282	2	1	96	1	0	0	0	0	0	0	0	1	8824	1103	39	2		2	LIPH	3	185245282	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	947033	185245282	12777148	48	6440											
BCL6	604	broad.mit.edu	37	chr3	187442788	187442788	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcagagtctgaaggtgccGgaaacgggtgccacagattt	13	9	2	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:187442788G>A	uc003frp.3	-	9	2375	c.1918C>T	c.(1918-1920)CGG>TGG	p.R640W	BCL6_uc011bsf.1_Missense_Mutation_p.R584W|BCL6_uc010hza.2_Missense_Mutation_p.R538W|BCL6_uc003frq.1_Missense_Mutation_p.R640W	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	640	C2H2-type 5.				negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		TGAAGGTGCCGGAAACGGGTG	0.557			T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								A	187442788	A	A	187442788	3	1	96	1	0	0	0	0	1	0	0	0	1376	1115	39	2	210	2	BCL6	3	187442788	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	2197506	187442788	10579642	49	6441											
TP63	8626	broad.mit.edu	37	chr3	189582118	189582118	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcagggagctgttatccGcgccatgcctgtctacaaaa	9	13	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr3:189582118G>A	uc003fry.2	+	5	766	c.677G>A	c.(676-678)CGC>CAC	p.R226H	TP63_uc003frx.2_Missense_Mutation_p.R226H|TP63_uc003frz.2_Missense_Mutation_p.R226H|TP63_uc010hzc.1_Missense_Mutation_p.R226H|TP63_uc003fsa.2_Missense_Mutation_p.R132H|TP63_uc003fsb.2_Missense_Mutation_p.R132H|TP63_uc003fsc.2_Missense_Mutation_p.R132H|TP63_uc003fsd.2_Missense_Mutation_p.R132H|TP63_uc010hzd.1_Missense_Mutation_p.R47H|TP63_uc003fse.1_Missense_Mutation_p.R107H	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	226					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GCTGTTATCCGCGCCATGCCT	0.522									Hay-Wells_syndrome	HNSCC(45;0.13)			A	189582118	A	A	189582118	3	1	96	1	0	0	0	0	1	0	0	0	16389	1087	38	1	741	1	TP63	3	189582118	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	2139330	189582118	8440312	50	6442											
ADD1	118	broad.mit.edu	37	chr4	2877779	2877779	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacatggcaccagaccttcGccaggacttcaacatgatgg	10	12	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr4:2877779G>A	uc003gfr.2	+	2	325	c.137G>A	c.(136-138)CGC>CAC	p.R46H	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Missense_Mutation_p.R46H|ADD1_uc003gfo.2_Missense_Mutation_p.R46H|ADD1_uc003gfp.2_Missense_Mutation_p.R46H|ADD1_uc003gfq.2_Missense_Mutation_p.R46H|ADD1_uc003gfs.2_Missense_Mutation_p.R46H|ADD1_uc003gft.3_Missense_Mutation_p.R46H	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	46					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCAGACCTTCGCCAGGACTTC	0.517													A	2877779	A	A	2877779	3	1	96	1	0	0	0	0	1	0	0	0	304	1087	38	1	139	1	ADD1	4	2877779	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		2877779	188276497	51	6443											
TMPRSS11F	389208	broad.mit.edu	37	chr4	68964683	68964683	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taatgtgaaaagagctagccGtactgagtcccaaaattgct	9	8	0	3	rs140054355	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr4:68964683G>A	uc003hdt.1	-	2	134	c.85C>T	c.(85-87)CGG>TGG	p.R29W		NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	29	Cytoplasmic (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AGAGCTAGCCGTACTGAGTCC	0.378													A	68964683	A	A	68964683	3	1	96	1	0	0	0	0	1	0	0	0	16240	1144	40	1	1267	1	TMPRSS11F	4	68964683	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	66086904	68964683	122189593	52	6444											
RXFP1	59350	broad.mit.edu	37	chr4	159567947	159567947	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actatgactcctctaggtgcCgactgcttaatgggaatata	9	9	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr4:159567947C>T	uc003ipz.2	+	16	1432	c.1350C>T	c.(1348-1350)GCC>GCT	p.A450A	RXFP1_uc011cja.1_Silent_p.A345A|RXFP1_uc010iqo.2_Silent_p.A402A|RXFP1_uc011cjb.1_Silent_p.A348A|RXFP1_uc010iqk.2_Silent_p.A318A|RXFP1_uc011cjc.1_Silent_p.A369A|RXFP1_uc011cjd.1_Silent_p.A369A|RXFP1_uc010iql.2_Silent_p.A294A|RXFP1_uc011cje.1_Silent_p.A477A|RXFP1_uc010iqm.2_Silent_p.A417A|RXFP1_uc011cjf.1_Silent_p.A319A|RXFP1_uc010iqn.2_Silent_p.A395A	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	450	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		CTCTAGGTGCCGACTGCTTAA	0.348													T	159567947	T	T	159567947	2	4	96	1	0	0	0	0	0	0	0	1	13759	639	23	2		2	RXFP1	4	159567947	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	90603264	159567947	31586329	53	6445											
ASB5	140458	broad.mit.edu	37	chr4	177143569	177143569	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttactgcatttacattataAccctaaatgtggcataattt	5	7	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr4:177143569A>G	uc003iuq.1	-	3	295	c.279T>C	c.(277-279)GGT>GGC	p.G93G	ASB5_uc003iup.1_Silent_p.G40G	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	93	ANK 1.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TTACATTATAACCCTAAATGT	0.398													G	177143569	G	G	177143569	2	3	96	1	0	0	0	0	0	0	0	1	1026	30	2	4		4	ASB5	4	177143569	Silent	SNP	A	TCGA-06-5858-01A-01D-1696-08	17575622	177143569	14010707	54	6446											
ZFP42	132625	broad.mit.edu	37	chr4	188924752	188924752	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggactttaatttgcgtaCgcacgtgcgcatccacacgg	10	12	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr4:188924752C>T	uc003izg.1	+	3	1036	c.791C>T	c.(790-792)ACG>ATG	p.T264M	ZFP42_uc003izh.1_Missense_Mutation_p.T264M|ZFP42_uc003izi.1_Missense_Mutation_p.T264M	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	264	C2H2-type 3.				female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AATTTGCGTACGCACGTGCGC	0.483													T	188924752	T	T	188924752	3	4	96	1	0	0	0	0	1	0	0	0	17647	536	19	1	793	1	ZFP42	4	188924752	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	11781183	188924752	2229524	55	6447											
NIPBL	25836	broad.mit.edu	37	chr5	36984865	36984865	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagaccagcttctcaggagaCgggttctacgggaaatgggt	14	8	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:36984865C>T	uc003jkl.3	+	10	2082	c.1583C>T	c.(1582-1584)ACG>ATG	p.T528M	NIPBL_uc003jkk.3_Missense_Mutation_p.T528M|NIPBL_uc003jkm.1_Missense_Mutation_p.T407M	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	528					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TCTCAGGAGACGGGTTCTACG	0.448													T	36984865	T	T	36984865	3	4	96	1	0	0	0	0	1	0	0	0	10428	536	19	1	1617	1	NIPBL	5	36984865	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08		36984865	143930395	56	6448											
MAST4	375449	broad.mit.edu	37	chr5	66416869	66416869	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctaatgcctccctgaaacttCgaaggaaacctcgggaaagt	9	11	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:66416869C>T	uc003jut.1	+	13	1185	c.1117C>T	c.(1117-1119)CGA>TGA	p.R373*	MAST4_uc003juu.1_Nonsense_Mutation_p.R383*|MAST4_uc011cra.1_Nonsense_Mutation_p.R356*|MAST4_uc003juv.2_Nonsense_Mutation_p.R368*|MAST4_uc003juw.2_Nonsense_Mutation_p.R368*	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	565						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CCTGAAACTTCGAAGGAAACC	0.313													T	66416869	T	T	66416869	4	4	96	1	0	0	0	0	0	1	0	0	9327	876	31	2	1868	2	MAST4	5	66416869	Nonsense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	29432004	66416869	114498391	57	6449											
PDE8B	8622	broad.mit.edu	37	chr5	76709099	76709099	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgctgccgacgtcctgcacGccaccgctttctttcttgga	9	15	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:76709099G>A	uc003kfa.2	+	17	1921	c.1876G>A	c.(1876-1878)GCC>ACC	p.A626T	PDE8B_uc003kfb.2_Missense_Mutation_p.A606T|PDE8B_uc003kfc.2_Missense_Mutation_p.A571T|PDE8B_uc003kfd.2_Missense_Mutation_p.A579T|PDE8B_uc003kfe.2_Missense_Mutation_p.A529T	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	626	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		CGTCCTGCACGCCACCGCTTT	0.478													A	76709099	A	A	76709099	3	1	96	1	0	0	0	0	1	0	0	0	11654	1087	38	1	1942	1	PDE8B	5	76709099	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	10292230	76709099	104206161	58	6450											
FBXL17	64839	broad.mit.edu	37	chr5	107684192	107684192	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagatcttgtaacactggcCgaaatgaatatctttgagtt	9	6	2	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:107684192C>T	uc011cvc.1	-	4	1821	c.1414G>A	c.(1414-1416)GGC>AGC	p.G472S	FBXL17_uc003kon.3_Missense_Mutation_p.G74S	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	472											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		TAACACTGGCCGAAATGAATA	0.368													T	107684192	T	T	107684192	3	4	96	1	0	0	0	0	1	0	0	0	5713	652	23	2	715	2	FBXL17	5	107684192	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	30975093	107684192	73231068	59	6451											
KCNN2	3781	broad.mit.edu	37	chr5	113740527	113740527	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctcattatggataattgcCgcatggactgtccgagcttg	10	9	1	0	rs147034356	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:113740527C>T	uc003kqo.2	+	3	1432	c.975C>T	c.(973-975)GCC>GCT	p.A325A		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	325	Helical; Name=Segment S5; (Potential).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		GGATAATTGCCGCATGGACTG	0.328													T	113740527	T	T	113740527	2	4	96	1	0	0	0	0	0	0	0	1	8079	639	23	2		2	KCNN2	5	113740527	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	6056335	113740527	67174733	60	6452											
PCDHA3	56145	broad.mit.edu	37	chr5	140180853	140180853	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcttctgctcctcgcagcctCggaggtggggagcggccagc	15	14	2	0	rs147990915		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:140180853C>T	uc003lhf.2	+	1	71	c.71C>T	c.(70-72)TCG>TTG	p.S24L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.S24L	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	24					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCGCAGCCTCGGAGGTGGGG	0.597													T	140180853	T	T	140180853	3	4	96	1	0	0	0	0	1	0	0	0	11525	893	31	2	73	2	PCDHA3	5	140180853	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	26440326	140180853	40734407	61	6453											
PCDHA4	56144	broad.mit.edu	37	chr5	140188279	140188279	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcggcgggtaggggagcgcGcgctgtcgagctacgtttcg	19	10	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:140188279G>A	uc003lhi.2	+	1	1608	c.1507G>A	c.(1507-1509)GCG>ACG	p.A503T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.A503T|PCDHA4_uc011daa.1_Missense_Mutation_p.A503T	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGGGAGCGCGCGCTGTCGAG	0.662													A	140188279	A	A	140188279	3	1	96	1	0	0	0	0	1	0	0	0	11526	1087	38	1	1509	1	PCDHA4	5	140188279	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	7426	140188279	40726981	62	6454											
PCDHB4	56131	broad.mit.edu	37	chr5	140502471	140502471	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcaataaatgaagtcacGggagaaatactgttgaaaaa	8	5	2	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:140502471G>A	uc003lip.1	+	1	891	c.891G>A	c.(889-891)ACG>ACA	p.T297T		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	297	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGAAGTCACGGGAGAAATAC	0.358													A	140502471	A	A	140502471	2	1	96	1	0	0	0	0	0	0	0	1	11544	1103	39	2		2	PCDHB4	5	140502471	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	314192	140502471	40412789	63	6455											
PCDHGA1	56114	broad.mit.edu	37	chr5	140712338	140712338	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactctgtacctggtggtggCggcggccgcggtctcctgcg	16	14	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:140712338C>T	uc003lji.1	+	1	2087	c.2087C>T	c.(2086-2088)GCG>GTG	p.A696V	PCDHGA1_uc011dan.1_Missense_Mutation_p.A696V	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	696	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGTGGTGGCGGCGGCCGCG	0.672													T	140712338	T	T	140712338	3	4	96	1	0	0	0	0	1	0	0	0	11550	768	27	1	2089	1	PCDHGA1	5	140712338	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	209867	140712338	40202922	64	6456											
PCDHGB6	56100	broad.mit.edu	37	chr5	140789386	140789386	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggcccgcgaccacggctcGcccacgctcagcgccaacgt	11	20	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:140789386G>A	uc003lkj.1	+	1	1617	c.1617G>A	c.(1615-1617)TCG>TCA	p.S539S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.S539S	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	539	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCACGGCTCGCCCACGCTCA	0.701													A	140789386	A	A	140789386	2	1	96	1	0	0	0	0	0	0	0	1	11567	1074	38	1		1	PCDHGB6	5	140789386	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	77048	140789386	40125874	65	6457											
PCDHGA11	56105	broad.mit.edu	37	chr5	140802272	140802272	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggtcacttactctctgaCggatgacactgtccaggggg	12	12	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:140802272C>T	uc003lkq.1	+	1	1736	c.1478C>T	c.(1477-1479)ACG>ATG	p.T493M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.T493M|PCDHGA11_uc003lkp.1_Missense_Mutation_p.T493M	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	493	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACTCTCTGACGGATGACACT	0.532													T	140802272	T	T	140802272	3	4	96	1	0	0	0	0	1	0	0	0	11552	536	19	1	1480	1	PCDHGA11	5	140802272	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	12886	140802272	40112988	66	6458											
PDGFRB	5159	broad.mit.edu	37	chr5	149497261	149497261	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcagggggatgatatagtcGttgtcaccctcattgggctg	15	8	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:149497261G>A	uc003lro.2	-	22	3526	c.3057C>T	c.(3055-3057)AAC>AAT	p.N1019N	PDGFRB_uc010jhd.2_Silent_p.N858N	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	1019	Cytoplasmic (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TGATATAGTCGTTGTCACCCT	0.642			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								A	149497261	A	A	149497261	2	1	96	1	0	0	0	0	0	0	0	1	11662	1136	40	1		1	PDGFRB	5	149497261	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	8694989	149497261	31417999	67	6459											
FGF18	8817	broad.mit.edu	37	chr5	170883601	170883601	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttctggagaacaactacaCggccctgatgtcggctaagt	12	10	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:170883601C>T	uc003mbk.2	+	5	953	c.416C>T	c.(415-417)ACG>ATG	p.T139M		NM_003862	NP_003853	O76093	FGF18_HUMAN	fibroblast growth factor 18 precursor	139					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AACAACTACACGGCCCTGATG	0.562													T	170883601	T	T	170883601	3	4	96	1	0	0	0	0	1	0	0	0	5846	536	19	1	434	1	FGF18	5	170883601	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	21386340	170883601	10031659	68	6460											
TSPAN17	26262	broad.mit.edu	37	chr5	176078841	176078841	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagttggaggcgtcatgtcGgtgctgggctttgctggctg	18	7	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr5:176078841G>A	uc003met.2	+	3	454	c.225G>A	c.(223-225)TCG>TCA	p.S75S	TSPAN17_uc003mes.3_Intron|TSPAN17_uc003meu.2_Silent_p.S75S|TSPAN17_uc003mev.2_Silent_p.S75S|TSPAN17_uc003mew.2_Silent_p.S75S	NM_012171	NP_036303	Q96FV3	TSN17_HUMAN	transmembrane 4 superfamily member 17 isoform a	75	Helical; (Potential).					integral to membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0	all_cancers(89;0.00141)|Renal(175;0.000269)|Lung NSC(126;0.00814)|all_lung(126;0.0133)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGTCATGTCGGTGCTGGGCT	0.612													A	176078841	A	A	176078841	2	1	96	1	0	0	0	0	0	0	0	1	16638	1103	39	2		2	TSPAN17	5	176078841	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	5195240	176078841	4836419	69	6461											
WRNIP1	56897	broad.mit.edu	37	chr6	2770518	2770518	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	actattttaatgcgagcgatCaactccctgggaatccacgt	8	11	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:2770518C>T	uc003mtz.2	+	3	1370	c.1179C>T	c.(1177-1179)ATC>ATT	p.I393I	WRNIP1_uc003mua.2_Silent_p.I368I	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	393					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				TGCGAGCGATCAACTCCCTGG	0.532													T	2770518	T	T	2770518	2	4	96	1	0	0	0	0	0	0	0	1	17400	816	29	3		3	WRNIP1	6	2770518	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08		2770518	168344549	70	6462											
SLC35B3	51000	broad.mit.edu	37	chr6	8422856	8422856	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catgtaggtttttcctggtaTtctgtaaaagacaattttta	7	5	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:8422856T>C	uc010joe.2	-	5	587	c.421A>G	c.(421-423)ATA>GTA	p.I141V	SLC35B3_uc003mya.2_Missense_Mutation_p.I109V|SLC35B3_uc003myc.2_Intron|SLC35B3_uc003myb.2_Missense_Mutation_p.I141V|SLC35B3_uc011did.1_Missense_Mutation_p.I141V|SLC35B3_uc003myd.2_RNA	NM_001142541	NP_001136013	Q9H1N7	S35B3_HUMAN	solute carrier family 35, member B3	141					transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)					TTTCCTGGTATTCTGTAAAAG	0.338													C	8422856	C	C	8422856	3	2	96	1	0	0	0	0	1	0	0	0	14577	1507	52	4	812	4	SLC35B3	6	8422856	Missense_Mutation	SNP	T	TCGA-06-5858-01A-01D-1696-08	5652338	8422856	162692211	71	6463											
HIVEP1	3096	broad.mit.edu	37	chr6	12124017	12124017	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catagaggacgtttctaaaaCggaggcttcccccaaaatcg	9	11	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:12124017C>T	uc003nac.2	+	4	4168	c.3989C>T	c.(3988-3990)ACG>ATG	p.T1330M	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1330					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GTTTCTAAAACGGAGGCTTCC	0.433													T	12124017	T	T	12124017	3	4	96	1	0	0	0	0	1	0	0	0	7186	536	19	1	3999	1	HIVEP1	6	12124017	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	3701161	12124017	158991050	72	6464											
SIRT5	23408	broad.mit.edu	37	chr6	13588650	13588650	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagtgcagaaagtggtgttcCgaccttcagaggagctggag	15	7	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:13588650C>T	uc003nay.2	+	4	499	c.203C>T	c.(202-204)CCG>CTG	p.P68L	SIRT5_uc003naw.2_Missense_Mutation_p.P68L|SIRT5_uc003nax.2_Intron|SIRT5_uc011dit.1_Missense_Mutation_p.P68L	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	68	NAD.|Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	AGTGGTGTTCCGACCTTCAGA	0.423													T	13588650	T	T	13588650	3	4	96	1	0	0	0	0	1	0	0	0	14341	652	23	2	209	2	SIRT5	6	13588650	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	1464633	13588650	157526417	73	6465											
SCAND3	114821	broad.mit.edu	37	chr6	28554340	28554340	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaactgcctgaagcgctgaCgagagagttccctggtataa	12	9	0	4			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:28554340C>T	uc003nlo.2	-	1	773	c.155G>A	c.(154-156)CGT>CAT	p.R52H	uc003nlp.1_5'Flank	NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	52	SCAN box.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GAAGCGCTGACGAGAGAGTTC	0.507													T	28554340	T	T	28554340	3	4	96	1	0	0	0	0	1	0	0	0	13876	536	19	1	3838	1	SCAND3	6	28554340	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	14965690	28554340	142560727	74	6466											
CSNK2B	1460	broad.mit.edu	37	chr6	31637206	31637206	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacggatggcgcctacttcGgcactggtttccctcacatg	10	14	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:31637206G>A	uc003nvr.1	+	6	818	c.478G>A	c.(478-480)GGC>AGC	p.G160S	CSNK2B_uc003nvs.1_Missense_Mutation_p.G160S|LY6G5B_uc003nvt.1_5'Flank	NM_001320	NP_001311	P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	160					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding				0						CGCCTACTTCGGCACTGGTTT	0.562													A	31637206	A	A	31637206	3	1	96	1	0	0	0	0	1	0	0	0	3959	1116	39	2	496	2	CSNK2B	6	31637206	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	3082866	31637206	139477861	75	6467											
EHMT2	10919	broad.mit.edu	37	chr6	31852241	31852241	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttgcggttgagttgaagcGcaaaccacacgtcggagcgc	14	11	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:31852241G>A	uc003nxz.1	-	21	2709	c.2699C>T	c.(2698-2700)GCG>GTG	p.A900V	EHMT2_uc003nxv.1_5'UTR|EHMT2_uc003nxw.1_5'UTR|EHMT2_uc003nxx.1_Missense_Mutation_p.A98V|EHMT2_uc003nxy.1_Missense_Mutation_p.A698V|EHMT2_uc011don.1_Missense_Mutation_p.A923V|EHMT2_uc003nya.1_Missense_Mutation_p.A866V	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	900					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GAGTTGAAGCGCAAACCACAC	0.612													A	31852241	A	A	31852241	3	1	96	1	0	0	0	0	1	0	0	0	4984	1087	38	1	965	1	EHMT2	6	31852241	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	215035	31852241	139262826	76	6468											
CYP21A2	1589	broad.mit.edu	37	chr6	32008215	32008215	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcaggaggagctagaccaCgaactgggccctggtgcctc	14	13	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:32008215C>T	uc003nze.1	+	8	1090	c.972C>T	c.(970-972)CAC>CAT	p.H324H	CYP21A2_uc003nzf.1_Silent_p.H294H	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	323					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						AGCTAGACCACGAACTGGGCC	0.677													T	32008215	T	T	32008215	2	4	96	1	0	0	0	0	0	0	0	1	4153	535	19	1		1	CYP21A2	6	32008215	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	155974	32008215	139106852	77	6469											
USP49	25862	broad.mit.edu	37	chr6	41773646	41773646	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaagagggtgtgcagttcaCggcagagggaaatgtgcttt	17	5	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:41773646C>T	uc003ori.2	-	4	1298	c.1076G>A	c.(1075-1077)CGT>CAT	p.R359H		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	359					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GTGCAGTTCACGGCAGAGGGA	0.602													T	41773646	T	T	41773646	3	4	96	1	0	0	0	0	1	0	0	0	17077	536	19	1	862	1	USP49	6	41773646	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	9765431	41773646	129341421	78	6470											
GPR116	221395	broad.mit.edu	37	chr6	46836637	46836637	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caccattccactccctggtcGaggtcttgactgtcagtact	8	14	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:46836637G>A	uc003oyo.3	-	12	1893	c.1604C>T	c.(1603-1605)TCG>TTG	p.S535L	GPR116_uc011dwj.1_Missense_Mutation_p.S90L|GPR116_uc011dwk.1_5'UTR|GPR116_uc003oyp.3_Missense_Mutation_p.S393L|GPR116_uc003oyq.3_Missense_Mutation_p.S535L|GPR116_uc010jzi.1_Missense_Mutation_p.S207L	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	535	Ig-like 3.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CTCCCTGGTCGAGGTCTTGAC	0.393													A	46836637	A	A	46836637	3	1	96	1	0	0	0	0	1	0	0	0	6633	1059	37	2	2476	2	GPR116	6	46836637	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	5062991	46836637	124278430	79	6471											
GPR116	221395	broad.mit.edu	37	chr6	46836810	46836810	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagaaacagaaattgggtcCggggttattgttagattggc	13	5	1	3	rs150327469		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:46836810C>T	uc003oyo.3	-	12	1720	c.1431G>A	c.(1429-1431)CCG>CCA	p.P477P	GPR116_uc011dwj.1_Silent_p.P32P|GPR116_uc011dwk.1_5'UTR|GPR116_uc003oyp.3_Silent_p.P335P|GPR116_uc003oyq.3_Silent_p.P477P|GPR116_uc010jzi.1_Silent_p.P149P	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	477	Ig-like 3.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			AAATTGGGTCCGGGGTTATTG	0.363													T	46836810	T	T	46836810	2	4	96	1	0	0	0	0	0	0	0	1	6633	639	23	2		2	GPR116	6	46836810	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	173	46836810	124278257	80	6472											
TAB2	23118	broad.mit.edu	37	chr6	149699411	149699411	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtggccagtccaatagtgaActatttcagcaggagccaca	11	10	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:149699411A>G	uc003qmj.2	+	3	538	c.360A>G	c.(358-360)GAA>GAG	p.E120E	TAB2_uc011eec.1_Silent_p.E88E|TAB2_uc010kia.1_Silent_p.E120E|TAB2_uc010kib.1_Silent_p.E120E|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	120					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						CCAATAGTGAACTATTTCAGC	0.458													G	149699411	G	G	149699411	2	3	96	1	0	0	0	0	0	0	0	1	15493	40	2	4		4	TAB2	6	149699411	Silent	SNP	A	TCGA-06-5858-01A-01D-1696-08	102862601	149699411	21415656	81	6473											
MLLT4	4301	broad.mit.edu	37	chr6	168348980	168348980	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacattttacaggagcagaCgcctccgcctagacctgaag	9	13	1	3	rs145954704	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr6:168348980C>T	uc003qwd.2	+	28	3771	c.3629C>T	c.(3628-3630)ACG>ATG	p.T1210M	MLLT4_uc003qwb.1_Missense_Mutation_p.T1195M|MLLT4_uc003qwc.1_Missense_Mutation_p.T1211M|MLLT4_uc003qwg.1_Missense_Mutation_p.T520M	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1211					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CAGGAGCAGACGCCTCCGCCT	0.418			T	MLL	AL								T	168348980	T	T	168348980	3	4	96	1	0	0	0	0	1	0	0	0	9629	536	19	1	3742	1	MLLT4	6	168348980	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	18649569	168348980	2766087	82	6474											
SDK1	221935	broad.mit.edu	37	chr7	4091337	4091337	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tattgccccagatttccacgGagtccaccatggacacataa	7	13	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:4091337G>A	uc003smx.2	+	19	2925	c.2786G>A	c.(2785-2787)GGA>GAA	p.G929E	SDK1_uc010kso.2_Missense_Mutation_p.G205E	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	929	Fibronectin type-III 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GATTTCCACGGAGTCCACCAT	0.567													A	4091337	A	A	4091337	3	1	96	1	0	0	0	0	1	0	0	0	13968	1174	41	3	2860	3	SDK1	7	4091337	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		4091337	155047326	83	6475											
PAPOLB	56903	broad.mit.edu	37	chr7	4900644	4900644	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatttccgtacaagagttgaCgctactgcatttggataaag	9	7	0	2	rs112213840		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:4900644C>T	uc003snk.2	-	1	982	c.798G>A	c.(796-798)GCG>GCA	p.A266A	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	265					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		CAAGAGTTGACGCTACTGCAT	0.428													T	4900644	T	T	4900644	2	4	96	1	0	0	0	0	0	0	0	1	11430	523	19	1		1	PAPOLB	7	4900644	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	809307	4900644	154238019	84	6476											
FBXL18	80028	broad.mit.edu	37	chr7	5521489	5521489	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgcaccagggggacgtcccGgatgacgtcggtcaggccct	16	13	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:5521489G>T	uc003son.3	-	5	2168	c.2074C>A	c.(2074-2076)CGG>AGG	p.R692R		NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	Error:Variant_position_missing_in_Q96ME1_after_alignment										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GGGACGTCCCGGATGACGTCG	0.642													T	5521489	T	T	5521489	2	4	96	1	0	0	0	0	0	0	0	1	5714	1115	39	5		5	FBXL18	7	5521489	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	620845	5521489	153617174	85	6477											
FBXL18	80028	broad.mit.edu	37	chr7	5540355	5540355	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtccccgacactctgtgcGcggctgcagggtgggagcga	17	12	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:5540355G>A	uc003soo.2	-	3	1639	c.1545C>T	c.(1543-1545)CGC>CGT	p.R515R	FBXL18_uc003son.3_Silent_p.R515R	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	515										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		CACTCTGTGCGCGGCTGCAGG	0.687													A	5540355	A	A	5540355	2	1	96	1	0	0	0	0	0	0	0	1	5714	1074	38	1		1	FBXL18	7	5540355	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	18866	5540355	153598308	86	6478											
MRPL32	64983	broad.mit.edu	37	chr7	42974713	42974713	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggtgtaggagaagaaatcCgcagaagcttattaaagtta	11	6	0	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:42974713C>T	uc003tia.2	+	2	337	c.290C>T	c.(289-291)CCG>CTG	p.P97L	C7orf25_uc010kxr.2_5'Flank|PSMA2_uc003thy.2_5'Flank|PSMA2_uc010kxt.2_5'Flank|PSMA2_uc003thz.1_5'Flank|MRPL32_uc003tib.2_RNA|MRPL32_uc003tic.2_Missense_Mutation_p.P44L	NM_031903	NP_114109	Q9BYC8	RM32_HUMAN	mitochondrial ribosomal protein L32 precursor	97					translation	large ribosomal subunit|mitochondrial ribosome	structural constituent of ribosome				0						AGAAGAAATCCGCAGAAGCTT	0.408													T	42974713	T	T	42974713	3	4	96	1	0	0	0	0	1	0	0	0	9795	652	23	2	296	2	MRPL32	7	42974713	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	37434358	42974713	116163950	87	6479											
ZMIZ2	83637	broad.mit.edu	37	chr7	44806136	44806136	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattcaaaccctcccccagcGtcccggcagtccttgggcca	8	19	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:44806136G>A	uc003tlr.2	+	18	2652	c.2529G>A	c.(2527-2529)GCG>GCA	p.A843A	ZMIZ2_uc003tlq.2_Silent_p.A785A|ZMIZ2_uc003tls.2_Silent_p.A817A|ZMIZ2_uc003tlt.2_Silent_p.A466A|ZMIZ2_uc010kyj.2_Silent_p.A365A|ZMIZ2_uc003tlu.2_Silent_p.A124A|ZMIZ2_uc010kyk.1_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	843	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CTCCCCCAGCGTCCCGGCAGT	0.647													A	44806136	A	A	44806136	2	1	96	1	0	0	0	0	0	0	0	1	17694	1132	40	1		1	ZMIZ2	7	44806136	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	1831423	44806136	114332527	88	6480											
TNS3	64759	broad.mit.edu	37	chr7	47342939	47342939	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttcccactggggcggtgccGaagcccaggaaggcctggct	15	14	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:47342939G>A	uc003tnv.2	-	22	3433	c.3066C>T	c.(3064-3066)TTC>TTT	p.F1022F	TNS3_uc003tnw.2_Silent_p.F1022F	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	1022						focal adhesion	protein binding			ovary(4)	4						GGGCGGTGCCGAAGCCCAGGA	0.682													A	47342939	A	A	47342939	2	1	96	1	0	0	0	0	0	0	0	1	16341	1049	37	2		2	TNS3	7	47342939	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	2536803	47342939	111795724	89	6481											
POM121L12	285877	broad.mit.edu	37	chr7	53104043	53104043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgagcaaaaatggagcggttGcttccttcgtgcccaggcca	12	11	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:53104043G>T	uc003tpz.2	+	1	695	c.679G>T	c.(679-681)GCT>TCT	p.A227S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	227											0						TGGAGCGGTTGCTTCCTTCGT	0.647													T	53104043	T	T	53104043	3	4	96	1	0	0	0	0	1	0	0	0	12241	1319	46	5	681	5	POM121L12	7	53104043	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	5761104	53104043	106034620	90	6482											
ZNF107	51427	broad.mit.edu	37	chr7	64168851	64168851	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagaaaccctacaaatgtgaAgaatgtggcaaatcctttaa	8	7	0	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:64168851A>G	uc003ttd.2	+	7	2955	c.2169A>G	c.(2167-2169)GAA>GAG	p.E723E	ZNF107_uc003tte.2_Silent_p.E723E	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	723	C2H2-type 24.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				ACAAATGTGAAGAATGTGGCA	0.348													G	64168851	G	G	64168851	2	3	96	1	0	0	0	0	0	0	0	1	17712	69	3	4		4	ZNF107	7	64168851	Silent	SNP	A	TCGA-06-5858-01A-01D-1696-08	11064808	64168851	94969812	91	6483											
CALN1	83698	broad.mit.edu	37	chr7	71252795	71252795	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggagtatctggttggctgCaatcagcatgacactgatga	12	9	2	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:71252795C>T	uc003twa.3	-	6	1152	c.625G>A	c.(625-627)GCA>ACA	p.A209T	CALN1_uc003twb.3_Missense_Mutation_p.A251T|CALN1_uc003twc.3_Missense_Mutation_p.A209T	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	209	Helical; Anchor for type IV membrane protein; (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TGGTTGGCTGCAATCAGCATG	0.587													T	71252795	T	T	71252795	3	4	96	1	0	0	0	0	1	0	0	0	2591	710	25	3	38	3	CALN1	7	71252795	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	7083944	71252795	87885868	92	6484											
RHBDD2	57414	broad.mit.edu	37	chr7	75511205	75511205	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccatctccctgctctgcggCgctatcatcatctggcgctt	8	17	5	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:75511205C>T	uc003udw.1	+	2	321	c.237C>T	c.(235-237)GGC>GGT	p.G79G	RHBDD2_uc003udv.1_5'UTR	NM_001040456	NP_001035546	Q6NTF9	RHBD2_HUMAN	rhomboid domain containing 2 isoform a	79	Helical; (Potential).					integral to membrane	serine-type endopeptidase activity				0						TGCTCTGCGGCGCTATCATCA	0.567													T	75511205	T	T	75511205	2	4	96	1	0	0	0	0	0	0	0	1	13317	755	27	1		1	RHBDD2	7	75511205	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	4258410	75511205	83627458	93	6485											
ZAN	7455	broad.mit.edu	37	chr7	100350423	100350423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctaccatctccacagaaaaaCtcaccatccccacagaaaaa	2	16	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:100350423C>T	uc003uwj.2	+	14	2860	c.2695C>T	c.(2695-2697)CTC>TTC	p.L899F	ZAN_uc003uwk.2_Missense_Mutation_p.L899F|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	899	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CACAGAAAAACTCACCATCCC	0.517													T	100350423	T	T	100350423	3	4	96	1	0	0	0	0	1	0	0	0	17510	565	20	3	2745	3	ZAN	7	100350423	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	24839218	100350423	58788240	94	6486											
SLC26A5	375611	broad.mit.edu	37	chr7	103014906	103014906	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcctcctgggaagggggagcCgaggcttcctgttcagcaag	15	11	1	0	rs138320783	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:103014906C>A	uc003vbz.2	-	20	2411	c.2175G>T	c.(2173-2175)TCG>TCT	p.S725S	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Silent_p.S693S|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	725	Cytoplasmic (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						AAGGGGGAGCCGAGGCTTCCT	0.532													A	103014906	A	A	103014906	2	1	96	1	0	0	0	0	0	0	0	1	14520	639	23	5		5	SLC26A5	7	103014906	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	2664483	103014906	56123757	95	6487											
RELN	5649	broad.mit.edu	37	chr7	103162532	103162532	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgtactcaatttccctccGttcacagtcagccagttctg	6	14	4	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:103162532G>A	uc003vca.2	-	48	7765	c.7605C>T	c.(7603-7605)AAC>AAT	p.N2535N	RELN_uc010liz.2_Silent_p.N2535N	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2535					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATTTCCCTCCGTTCACAGTCA	0.532													A	103162532	A	A	103162532	2	1	96	1	0	0	0	0	0	0	0	1	13220	1136	40	1		1	RELN	7	103162532	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	147626	103162532	55976131	96	6488											
CTTNBP2	83992	broad.mit.edu	37	chr7	117375046	117375046	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccaccgcagctgcacccagCggaaatgctgctgcaccagc	10	18	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:117375046C>T	uc003vjf.2	-	16	3889	c.3797G>A	c.(3796-3798)CGC>CAC	p.R1266H		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1266										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CTGCACCCAGCGGAAATGCTG	0.493													T	117375046	T	T	117375046	3	4	96	1	0	0	0	0	1	0	0	0	4045	768	27	1	1226	1	CTTNBP2	7	117375046	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	14212514	117375046	41763617	97	6489											
AASS	10157	broad.mit.edu	37	chr7	121773679	121773679	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggcccttctctcccaggcGttcacatcctccctccggac	9	19	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:121773679G>A	uc003vka.2	-	1	198	c.102C>T	c.(100-102)AAC>AAT	p.N34N	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.N34N|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	34	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	TCTCCCAGGCGTTCACATCCT	0.582													A	121773679	A	A	121773679	2	1	96	1	0	0	0	0	0	0	0	1	24	1136	40	1		1	AASS	7	121773679	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	4398633	121773679	37364984	98	6490											
NRF1	4899	broad.mit.edu	37	chr7	129357145	129357145	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacccaggcggtggcatcGttggcagaggccgcagtggc	17	13	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:129357145G>A	uc003voz.2	+	9	1269	c.1152G>A	c.(1150-1152)TCG>TCA	p.S384S	NRF1_uc003vpa.2_Silent_p.S384S|NRF1_uc011kpa.1_Silent_p.S223S|NRF1_uc003vpb.2_Silent_p.S384S	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	384	Required for transcriptional activation.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						CGGTGGCATCGTTGGCAGAGG	0.572													A	129357145	A	A	129357145	2	1	96	1	0	0	0	0	0	0	0	1	10646	1132	40	1		1	NRF1	7	129357145	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	7583466	129357145	29781518	99	6491											
CPA1	1357	broad.mit.edu	37	chr7	130021608	130021608	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgatcgaggacgtgcagtcGctgctggacgaggagcagga	17	8	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:130021608G>A	uc003vpx.2	+	3	357	c.285G>A	c.(283-285)TCG>TCA	p.S95S	CPA1_uc011kpf.1_Silent_p.S7S|CPA1_uc003vpw.2_Intron	NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	95					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					ACGTGCAGTCGCTGCTGGACG	0.612											OREG0018314	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	130021608	A	A	130021608	2	1	96	1	0	0	0	0	0	0	0	1	3789	1074	38	1		1	CPA1	7	130021608	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	664463	130021608	29117055	100	6492											
HIPK2	28996	broad.mit.edu	37	chr7	139259877	139259877	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccagctgtggggcttacctgGctgagattgagtggctgctg	16	9	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:139259877G>C	uc003vvf.3	-	14	3297	c.3123C>G	c.(3121-3123)AGC>AGG	p.S1041R	HIPK2_uc003vvd.3_Missense_Mutation_p.S1014R	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	1041	Autoinhibitory domain (AID).|Interaction with AXIN1 (By similarity).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					GGCTTACCTGGCTGAGATTGA	0.672													C	139259877	C	C	139259877	3	2	96	1	0	0	0	0	1	0	0	0	7117	1194	42	5	481	5	HIPK2	7	139259877	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	9238269	139259877	19878786	101	6493											
ZNF425	155054	broad.mit.edu	37	chr7	148815402	148815402	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggatctcccactcttgttcCgaaaaatataaggccacatc	6	12	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:148815402C>T	uc003wfj.2	-	2	130	c.57G>A	c.(55-57)TCG>TCA	p.S19S		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	19	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			ACTCTTGTTCCGAAAAATATA	0.393													T	148815402	T	T	148815402	2	4	96	1	0	0	0	0	0	0	0	1	17896	639	23	2		2	ZNF425	7	148815402	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	9555525	148815402	10323261	102	6494											
SLC4A2	6522	broad.mit.edu	37	chr7	150771186	150771186	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagctcagaggtggacggcGgtgagaacatgacatgggcc	16	9	1	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:150771186G>A	uc003wit.3	+	17	2852	c.2596G>A	c.(2596-2598)GGT>AGT	p.G866S	SLC4A2_uc011kve.1_Missense_Mutation_p.G857S|SLC4A2_uc003wiu.3_Missense_Mutation_p.G852S|SLC4A2_uc003wiv.3_Missense_Mutation_p.G60S	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	866	Membrane (anion exchange).|Extracellular (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGTGGACGGCGGTGAGAACAT	0.677													A	150771186	A	A	150771186	3	1	96	1	0	0	0	0	1	0	0	0	14654	1116	39	2	2658	2	SLC4A2	7	150771186	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	1955784	150771186	8367477	103	6495											
MLL3	58508	broad.mit.edu	37	chr7	151878185	151878185	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctggtcctcggttttgtgCtgcttgcaggaaaggatcct	13	9	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:151878185C>T	uc003wla.2	-	36	6979	c.6760G>A	c.(6760-6762)GCA>ACA	p.A2254T	MLL3_uc003wkz.2_Missense_Mutation_p.A1315T	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2254	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CGGTTTTGTGCTGCTTGCAGG	0.527			N		medulloblastoma								T	151878185	T	T	151878185	3	4	96	1	0	0	0	0	1	0	0	0	9622	797	28	3	8071	3	MLL3	7	151878185	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	1106999	151878185	7260478	104	6496											
HTR5A	3361	broad.mit.edu	37	chr7	154863298	154863298	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacaaggctgccaagttccGcgtgggctccaggaagacca	12	13	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:154863298G>A	uc003wlu.1	+	1	753	c.689G>A	c.(688-690)CGC>CAC	p.R230H	uc011kvt.1_5'Flank|uc003wlt.2_5'Flank	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	230	Cytoplasmic (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GCCAAGTTCCGCGTGGGCTCC	0.542													A	154863298	A	A	154863298	3	1	96	1	0	0	0	0	1	0	0	0	7450	1087	38	1	691	1	HTR5A	7	154863298	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	2985113	154863298	4275365	105	6497											
PTPRN2	5799	broad.mit.edu	37	chr7	157370776	157370776	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtagcactgccggacgccGttctccgcgaggggtgtcag	16	12	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:157370776G>A	uc003wno.2	-	18	2674	c.2553C>T	c.(2551-2553)AAC>AAT	p.N851N	PTPRN2_uc003wnp.2_Silent_p.N834N|PTPRN2_uc003wnq.2_Silent_p.N822N|PTPRN2_uc003wnr.2_Silent_p.N813N|PTPRN2_uc011kwa.1_Silent_p.N874N	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	851	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GCCGGACGCCGTTCTCCGCGA	0.622													A	157370776	A	A	157370776	2	1	96	1	0	0	0	0	0	0	0	1	12808	1136	40	1		1	PTPRN2	7	157370776	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	2507478	157370776	1767887	106	6498											
VIPR2	7434	broad.mit.edu	37	chr7	158896531	158896531	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatccgtcactcgtacagtTtttgcttatgtttcctggaa	7	11	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr7:158896531T>C	uc003woh.2	-	4	460	c.274A>G	c.(274-276)AAC>GAC	p.N92D	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	92	Extracellular (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CTCGTACAGTTTTTGCTTATG	0.512													C	158896531	C	C	158896531	3	2	96	1	0	0	0	0	1	0	0	0	17167	1841	64	4	1082	4	VIPR2	7	158896531	Missense_Mutation	SNP	T	TCGA-06-5858-01A-01D-1696-08	1525755	158896531	242132	107	6499											
KIAA1429	25962	broad.mit.edu	37	chr8	95521969	95521969	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atattcaacacactgttggcGaataacactgtctccaggag	8	10	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr8:95521969G>A	uc003ygo.1	-	15	3839	c.3826C>T	c.(3826-3828)CGC>TGC	p.R1276C	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1276					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CACTGTTGGCGAATAACACTG	0.348													A	95521969	A	A	95521969	3	1	96	1	0	0	0	0	1	0	0	0	8231	1058	37	2	1652	2	KIAA1429	8	95521969	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		95521969	50842053	108	6500											
TG	7038	broad.mit.edu	37	chr8	133880437	133880437	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctgaagcaagcagactacGtgccccagtgtgcagaggat	12	10	1	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr8:133880437G>A	uc003ytw.2	+	2	186	c.145G>A	c.(145-147)GTG>ATG	p.V49M		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	49	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCAGACTACGTGCCCCAGTG	0.532													A	133880437	A	A	133880437	3	1	96	1	0	0	0	0	1	0	0	0	15810	1145	40	1	151	1	TG	8	133880437	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	38358468	133880437	12483585	109	6501											
ZNF623	9831	broad.mit.edu	37	chr8	144732159	144732159	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgacgtcagacagactcacGgtgatggagctcccctctcc	10	15	3	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr8:144732159G>A	uc003yzd.2	+	1	206	c.117G>A	c.(115-117)ACG>ACA	p.T39T	ZNF623_uc011lkp.1_5'UTR|ZNF623_uc003yzc.2_5'UTR	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	39					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			ACAGACTCACGGTGATGGAGC	0.522													A	144732159	A	A	144732159	2	1	96	1	0	0	0	0	0	0	0	1	18044	1103	39	2		2	ZNF623	8	144732159	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	10851722	144732159	1631863	110	6502											
KIAA2026	158358	broad.mit.edu	37	chr9	5988438	5988438	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgtcaagcctgccaaacttCgcggtgttgaccgacgcctt	10	13	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:5988438C>T	uc003zjq.3	-	2	917	c.701G>A	c.(700-702)CGA>CAA	p.R234Q		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	234										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TGCCAAACTTCGCGGTGTTGA	0.423													T	5988438	T	T	5988438	3	4	96	1	0	0	0	0	1	0	0	0	8270	884	31	2	5638	2	KIAA2026	9	5988438	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08		5988438	135224993	111	6503											
ACER2	340485	broad.mit.edu	37	chr9	19423911	19423911	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccatctgcatgtgcttgtttCgtcagtatgcaacatgcttc	8	11	2	0	rs145427232		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:19423911C>T	uc003zny.1	+	2	318	c.160C>T	c.(160-162)CGT>TGT	p.R54C	ACER2_uc003znx.1_RNA|ACER2_uc003znz.1_Missense_Mutation_p.R5C	NM_001010887	NP_001010887	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2	54	Cytoplasmic (Potential).				ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity	p.R54C(1)		haematopoietic_and_lymphoid_tissue(1)|skin(1)	2						GTGCTTGTTTCGTCAGTATGC	0.398													T	19423911	T	T	19423911	3	4	96	1	0	0	0	0	1	0	0	0	139	884	31	2	166	2	ACER2	9	19423911	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	13435473	19423911	121789520	112	6504											
CCIN	881	broad.mit.edu	37	chr9	36169599	36169599	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgggacatggccctgagtGtggacaaccacgtcttcttt	11	11	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:36169599G>A	uc003zzb.3	+	1	211	c.100G>A	c.(100-102)GTG>ATG	p.V34M		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	34	BTB.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			GGCCCTGAGTGTGGACAACCA	0.502													A	36169599	A	A	36169599	3	1	96	1	0	0	0	0	1	0	0	0	2878	1377	48	3	102	3	CCIN	9	36169599	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	16745688	36169599	105043832	113	6505											
KIAA1529	57653	broad.mit.edu	37	chr9	100126341	100126341	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgtcccacagcttcacacCgcaccccaagcccaacaaaa	4	18	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:100126341C>T	uc011lut.1	+	41	5233	c.4460C>T	c.(4459-4461)CCG>CTG	p.P1487L	KIAA1529_uc004axe.1_Missense_Mutation_p.P1293L|KIAA1529_uc004axg.1_Missense_Mutation_p.P1348L|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Intron|MIR1302-8_hsa-mir-1302-8|MI0006369_5'Flank	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				AGCTTCACACCGCACCCCAAG	0.592													T	100126341	T	T	100126341	3	4	96	1	0	0	0	0	1	0	0	0	8240	652	23	2	3996	2	KIAA1529	9	100126341	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	63956742	100126341	41087090	114	6506											
SVEP1	79987	broad.mit.edu	37	chr9	113228166	113228166	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccacatgcagaaatgttcaCggctcctcttttcacagttg	7	12	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:113228166C>T	uc010mtz.2	-	18	3638	c.3301G>A	c.(3301-3303)GTG>ATG	p.V1101M	SVEP1_uc010mua.1_Missense_Mutation_p.V1101M	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1101					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GAAATGTTCACGGCTCCTCTT	0.438													T	113228166	T	T	113228166	3	4	96	1	0	0	0	0	1	0	0	0	15417	536	19	1	7538	1	SVEP1	9	113228166	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	13101825	113228166	27985265	115	6507											
COL27A1	85301	broad.mit.edu	37	chr9	116994128	116994128	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgggcagcgtgggggagccCggactgaaaggtgataaggt	19	6	0	2	rs144760825		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:116994128C>T	uc011lxl.1	+	16	2547	c.2547C>T	c.(2545-2547)CCC>CCT	p.P849P	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	849	Pro-rich.|Triple-helical region.|Collagen-like 4.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						TGGGGGAGCCCGGACTGAAAG	0.522													T	116994128	T	T	116994128	2	4	96	1	0	0	0	0	0	0	0	1	3685	639	23	2		2	COL27A1	9	116994128	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	3765962	116994128	24219303	116	6508											
DAB2IP	153090	broad.mit.edu	37	chr9	124528842	124528842	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagcagtcgcggccgcccGgacatcagtgagcggctcat	14	14	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:124528842G>A	uc004bln.2	+	9	1515	c.1446G>A	c.(1444-1446)CCG>CCA	p.P482P	DAB2IP_uc004blo.2_Silent_p.P386P|DAB2IP_uc004blp.2_5'Flank	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	510	Ras-GAP.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						GCGGCCGCCCGGACATCAGTG	0.617													A	124528842	A	A	124528842	2	1	96	1	0	0	0	0	0	0	0	1	4219	1103	39	2		2	DAB2IP	9	124528842	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	7534714	124528842	16684589	117	6509											
RC3H2	54542	broad.mit.edu	37	chr9	125617558	125617558	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacgggaagatctggaaatcGcaccccattttgagatgatg	11	8	1	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:125617558G>A	uc010mwc.1	-	15	2961	c.2720C>T	c.(2719-2721)GCG>GTG	p.A907V	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.A907V|RC3H2_uc004bne.3_Missense_Mutation_p.A907V	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	907						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						TCTGGAAATCGCACCCCATTT	0.443													A	125617558	A	A	125617558	3	1	96	1	0	0	0	0	1	0	0	0	13167	1087	38	1	961	1	RC3H2	9	125617558	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	1088716	125617558	15595873	118	6510											
STRBP	55342	broad.mit.edu	37	chr9	125922701	125922701	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcacaaatcacgcagaatgCggaggacaattacacatgat	9	9	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:125922701C>T	uc004bns.2	-	8	1098	c.668G>A	c.(667-669)CGC>CAC	p.R223H	STRBP_uc004bnt.2_Missense_Mutation_p.R41H|STRBP_uc004bnu.2_Missense_Mutation_p.R209H|STRBP_uc004bnv.2_Missense_Mutation_p.R223H	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	223	DZF.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						ACGCAGAATGCGGAGGACAAT	0.393													T	125922701	T	T	125922701	3	4	96	1	0	0	0	0	1	0	0	0	15326	768	27	1	1398	1	STRBP	9	125922701	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	305143	125922701	15290730	119	6511											
NTNG2	84628	broad.mit.edu	37	chr9	135073844	135073844	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacatggacaacctctacacGcggctggagagcgccaaggg	13	12	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:135073844G>A	uc004cbh.2	+	3	1481	c.705G>A	c.(703-705)ACG>ACA	p.T235T		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	235	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		ACCTCTACACGCGGCTGGAGA	0.677													A	135073844	A	A	135073844	2	1	96	1	0	0	0	0	0	0	0	1	10705	1074	38	1		1	NTNG2	9	135073844	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	9151143	135073844	6139587	120	6512											
SEC16A	9919	broad.mit.edu	37	chr9	139350207	139350207	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagtgccaggacactgctgCgggagggctccatcctgatg	16	11	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:139350207C>T	uc004chx.2	-	20	6012	c.5703G>A	c.(5701-5703)CCG>CCA	p.P1901P	SEC16A_uc004chs.2_5'Flank|SEC16A_uc004cht.2_5'Flank|SEC16A_uc004chu.2_Silent_p.P86P|SEC16A_uc004chv.3_Silent_p.P1291P|SEC16A_uc004chw.2_Silent_p.P1901P|SEC16A_uc010nbn.2_Silent_p.P1901P	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1723					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GACACTGCTGCGGGAGGGCTC	0.667													T	139350207	T	T	139350207	2	4	96	1	0	0	0	0	0	0	0	1	13986	755	27	1		1	SEC16A	9	139350207	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	4276363	139350207	1863224	121	6513											
SLC34A3	142680	broad.mit.edu	37	chr9	140128881	140128881	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccacagacttccccttcccGctgggctggctcggcggcta	11	18	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:140128881G>A	uc004cmf.1	+	11	1293	c.1107G>A	c.(1105-1107)CCG>CCA	p.P369P	SLC34A3_uc011met.1_Silent_p.P369P	NM_080877	NP_543153	Q8N130	NPT2C_HUMAN	solute carrier family 34 (sodium phosphate),	369	Helical; Name=M5; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TCCCCTTCCCGCTGGGCTGGC	0.716													A	140128881	A	A	140128881	2	1	96	1	0	0	0	0	0	0	0	1	14569	1074	38	1		1	SLC34A3	9	140128881	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	778674	140128881	1084550	122	6514											
PNPLA7	375775	broad.mit.edu	37	chr9	140356687	140356687	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagctgtcgatgggggggcGcaggtactcgcagtagtcac	17	9	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:140356687G>A	uc004cnf.2	-	30	3851	c.3514C>T	c.(3514-3516)CGC>TGC	p.R1172C	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_Missense_Mutation_p.R419C|PNPLA7_uc004cne.1_Missense_Mutation_p.R438C|PNPLA7_uc011mfa.1_Missense_Mutation_p.R580C|PNPLA7_uc010ncj.1_Missense_Mutation_p.R1197C|NELF_uc004cna.2_5'Flank|NELF_uc011mez.1_5'Flank|NELF_uc004cmz.2_5'Flank|NELF_uc004cnc.2_5'Flank|NELF_uc004cnb.2_5'Flank	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1172					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		ATGGGGGGGCGCAGGTACTCG	0.647													A	140356687	A	A	140356687	3	1	96	1	0	0	0	0	1	0	0	0	12170	1087	38	1	459	1	PNPLA7	9	140356687	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	227806	140356687	856744	123	6515											
PNPLA7	375775	broad.mit.edu	37	chr9	140361890	140361890	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacagggatgccgcactccGccaaggccttgagaacgccc	11	17	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr9:140361890G>A	uc004cnf.2	-	25	3180	c.2843C>T	c.(2842-2844)GCG>GTG	p.A948V	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_Missense_Mutation_p.A214V|PNPLA7_uc004cne.1_Missense_Mutation_p.A214V|PNPLA7_uc011mfa.1_Missense_Mutation_p.A356V|PNPLA7_uc010ncj.1_Missense_Mutation_p.A973V	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	948	Patatin.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GCCGCACTCCGCCAAGGCCTT	0.652													A	140361890	A	A	140361890	3	1	96	1	0	0	0	0	1	0	0	0	12170	1087	38	1	1150	1	PNPLA7	9	140361890	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	5203	140361890	851541	124	6516											
MYO3A	53904	broad.mit.edu	37	chr10	26243811	26243811	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttgaaactaggatattgaCgaagagattgaagcagaata	10	3	0	5	rs139958275	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr10:26243811C>T	uc001isn.2	+	4	537	c.177C>T	c.(175-177)GAC>GAT	p.D59D	MYO3A_uc009xko.1_Silent_p.D59D|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Silent_p.D59D|MYO3A_uc001ism.2_Silent_p.D59D	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	59	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AGGATATTGACGAAGAGATTG	0.313													T	26243811	T	T	26243811	2	4	96	1	0	0	0	0	0	0	0	1	10076	535	19	1		1	MYO3A	10	26243811	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08		26243811	109290936	125	6517											
HNRNPH3	3189	broad.mit.edu	37	chr10	70097039	70097039	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtgatgggacagtacgacttCgtggactaccatttggttgc	13	8	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr10:70097039C>T	uc001jnw.3	+	2	290	c.61C>T	c.(61-63)CGT>TGT	p.R21C	HNRNPH3_uc001jnx.3_Missense_Mutation_p.R21C|HNRNPH3_uc009xpu.2_5'UTR|HNRNPH3_uc010qiv.1_Missense_Mutation_p.R21C|HNRNPH3_uc001jny.3_5'Flank	NM_012207	NP_036339	P31942	HNRH3_HUMAN	heterogeneous nuclear ribonucleoprotein H3	21	RRM 1.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2						AGTACGACTTCGTGGACTACC	0.338													T	70097039	T	T	70097039	3	4	96	1	0	0	0	0	1	0	0	0	7268	884	31	2	63	2	HNRNPH3	10	70097039	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	43853228	70097039	65437708	126	6518											
RGR	5995	broad.mit.edu	37	chr10	86008738	86008738	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttccagggctttgtgacagcGttggccagcatctgcagcag	13	11	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr10:86008738G>A	uc001kdc.1	+	3	335	c.297G>A	c.(295-297)GCG>GCA	p.A99A	RGR_uc001kdb.1_Missense_Mutation_p.V87I|RGR_uc001kdd.1_Silent_p.A103A|RGR_uc001kde.1_Silent_p.A99A	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	99	Helical; Name=3; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding	p.A103A(1)		ovary(1)	1						TTGTGACAGCGTTGGCCAGCA	0.637													A	86008738	A	A	86008738	2	1	96	1	0	0	0	0	0	0	0	1	13291	1132	40	1		1	RGR	10	86008738	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	15911699	86008738	49526009	127	6519											
PTEN	5728	broad.mit.edu	37	chr10	89717672	89717672	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctccaattcaggacccacaCgacgggaagacaagttcatg	9	13	2	1	rs121909219		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr10:89717672C>T	uc001kfb.2	+	8	1728	c.697C>T	c.(697-699)CGA>TGA	p.R233*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R233*(61)|p.R233fs*10(4)|p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R233fs*25(1)|p.R233fs*23(1)|p.R233R(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGGACCCACACGACGGGAAGA	0.423	R233*(JHUEM1_ENDOMETRIUM)|R233*(SW1783_CENTRAL_NERVOUS_SYSTEM)|R233*(NCIH1155_LUNG)|R233*(SF295_CENTRAL_NERVOUS_SYSTEM)|R233*(HEC59_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89717672	T	T	89717672	4	4	96	1	0	0	0	0	0	1	0	0	12738	528	19	1	723	1	PTEN	10	89717672	Nonsense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	3708934	89717672	45817075	128	6520											
PLCE1	51196	broad.mit.edu	37	chr10	95995711	95995711	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacaagataatttcttacaaCgagtgggacaaaatggctta	9	6	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr10:95995711C>T	uc001kjk.2	+	7	2888	c.2254C>T	c.(2254-2256)CGA>TGA	p.R752*	PLCE1_uc010qnx.1_Nonsense_Mutation_p.R752*|PLCE1_uc001kjm.2_Nonsense_Mutation_p.R444*	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	752	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TTTCTTACAACGAGTGGGACA	0.408													T	95995711	T	T	95995711	4	4	96	1	0	0	0	0	0	1	0	0	12034	528	19	1	2562	1	PLCE1	10	95995711	Nonsense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	6278039	95995711	39539036	129	6521											
SORCS1	114815	broad.mit.edu	37	chr10	108923845	108923845	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggaagcgggtggctttgtccGggtcccgctcccgagtccca	15	14	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr10:108923845G>T	uc001kym.2	-	1	448	c.440C>A	c.(439-441)CCG>CAG	p.P147Q	SORCS1_uc001kyl.2_Missense_Mutation_p.P147Q|SORCS1_uc009xxs.2_Missense_Mutation_p.P147Q|SORCS1_uc001kyn.1_Missense_Mutation_p.P147Q|SORCS1_uc001kyo.2_Missense_Mutation_p.P147Q	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	147	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GGCTTTGTCCGGGTCCCGCTC	0.652													T	108923845	T	T	108923845	3	4	96	1	0	0	0	0	1	0	0	0	14930	1116	39	5	3404	5	SORCS1	10	108923845	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	12928134	108923845	26610902	130	6522											
SEC23IP	11196	broad.mit.edu	37	chr10	121663608	121663608	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctctagttcagccagatcCggagagcgtggttcttggca	12	10	3	2	rs147722288	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr10:121663608C>T	uc001leu.1	+	4	992	c.920C>T	c.(919-921)CCG>CTG	p.P307L	SEC23IP_uc010qtc.1_Missense_Mutation_p.P96L	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	307	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CAGCCAGATCCGGAGAGCGTG	0.408													T	121663608	T	T	121663608	3	4	96	1	0	0	0	0	1	0	0	0	13993	652	23	2	934	2	SEC23IP	10	121663608	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	12739763	121663608	13871139	131	6523											
CPXM2	119587	broad.mit.edu	37	chr10	125506288	125506288	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcccaggagggtcacccacGctgtcgtctcttctgccccc	11	18	3	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr10:125506288G>A	uc001lhk.1	-	14	2588	c.2263C>T	c.(2263-2265)CGT>TGT	p.R755C	CPXM2_uc001lhj.2_Intron	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	755					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GGTCACCCACGCTGTCGTCTC	0.577													A	125506288	A	A	125506288	3	1	96	1	0	0	0	0	1	0	0	0	3838	1087	38	1	11	1	CPXM2	10	125506288	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	3842680	125506288	10028459	132	6524											
CPXM2	119587	broad.mit.edu	37	chr10	125622179	125622179	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggccatagcgcttcaccGtggaggcatggagctggaag	15	11	1	0	rs146535848		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr10:125622179G>A	uc001lhk.1	-	3	789	c.464C>T	c.(463-465)ACG>ATG	p.T155M	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	155	F5/8 type C.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GCGCTTCACCGTGGAGGCATG	0.507													A	125622179	A	A	125622179	3	1	96	1	0	0	0	0	1	0	0	0	3838	1145	40	1	1854	1	CPXM2	10	125622179	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	115891	125622179	9912568	133	6525											
MRGPRE	116534	broad.mit.edu	37	chr11	3249728	3249728	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtagcagaagaagcgcagcGttgccaggctggtctgcacg	15	10	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:3249728G>A	uc001lxq.3	-	2	609	c.299C>T	c.(298-300)ACG>ATG	p.T100M		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	100	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAAGCGCAGCGTTGCCAGGCT	0.662													A	3249728	A	A	3249728	3	1	96	1	0	0	0	0	1	0	0	0	9764	1145	40	1	640	1	MRGPRE	11	3249728	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		3249728	131756788	134	6526											
SOX6	55553	broad.mit.edu	37	chr11	16036504	16036504	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaccctctgcatcttctggCcgagtaaggtcgatgacacc	9	14	4	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:16036504C>T	uc001mme.2	-	13	1788	c.1755G>A	c.(1753-1755)CGG>CGA	p.R585R	SOX6_uc001mmd.2_Silent_p.R548R|SOX6_uc001mmf.2_Silent_p.R545R|SOX6_uc001mmg.2_Silent_p.R572R	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	572					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						CATCTTCTGGCCGAGTAAGGT	0.463													T	16036504	T	T	16036504	2	4	96	1	0	0	0	0	0	0	0	1	14955	726	26	3		3	SOX6	11	16036504	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	12786776	16036504	118970012	135	6527											
PLEKHA7	144100	broad.mit.edu	37	chr11	16847767	16847767	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttggtcctgggaggaaaggCccgctggtacccaccagtcc	14	13	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:16847767C>T	uc001mmo.2	-	10	1258	c.1243G>A	c.(1243-1245)GCC>ACC	p.A415T	PLEKHA7_uc010rcu.1_Missense_Mutation_p.A415T|PLEKHA7_uc001mmn.2_Missense_Mutation_p.A123T	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	415					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						GGAGGAAAGGCCCGCTGGTAC	0.592													T	16847767	T	T	16847767	3	4	96	1	0	0	0	0	1	0	0	0	12061	739	26	3	2178	3	PLEKHA7	11	16847767	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	811263	16847767	118158749	136	6528											
NELL1	4745	broad.mit.edu	37	chr11	20959373	20959373	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagttcttgcagaaggccagCggattttaaccaagagctgt	11	8	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:20959373C>T	uc001mqe.2	+	10	1192	c.1039C>T	c.(1039-1041)CGG>TGG	p.R347W	NELL1_uc001mqf.2_Missense_Mutation_p.R347W|NELL1_uc009yid.2_Missense_Mutation_p.R375W|NELL1_uc010rdo.1_Missense_Mutation_p.R290W|NELL1_uc010rdp.1_Missense_Mutation_p.R107W	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	347	VWFC 2.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						AGAAGGCCAGCGGATTTTAAC	0.408													T	20959373	T	T	20959373	3	4	96	1	0	0	0	0	1	0	0	0	10333	759	27	1	1077	1	NELL1	11	20959373	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	4111606	20959373	114047143	137	6529											
GYLTL1B	120071	broad.mit.edu	37	chr11	45950278	45950278	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgctccagccccacctatcGtgactgcctccaggccctca	7	21	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:45950278G>A	uc001nbv.1	+	14	2159	c.2048G>A	c.(2047-2049)CGT>CAT	p.R683H	GYLTL1B_uc001nbw.1_Missense_Mutation_p.R652H|GYLTL1B_uc001nbx.1_Missense_Mutation_p.R683H|GYLTL1B_uc001nby.1_Missense_Mutation_p.R366H|GYLTL1B_uc001nbz.1_Missense_Mutation_p.V32M	NM_152312	NP_689525	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	683	Lumenal (Potential).				muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.226)		CCCACCTATCGTGACTGCCTC	0.637													A	45950278	A	A	45950278	3	1	96	1	0	0	0	0	1	0	0	0	6907	1145	40	1	2098	1	GYLTL1B	11	45950278	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	24990905	45950278	89056238	138	6530											
CHRM4	1132	broad.mit.edu	37	chr11	46406690	46406690	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctggcagtgccgatgttcCgatactggcacagcagcagg	13	12	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:46406690C>T	uc001nct.1	-	1	1418	c.1418G>A	c.(1417-1419)CGG>CAG	p.R473Q		NM_000741	NP_000732	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	473	Cytoplasmic (By similarity).				cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity				0				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	GCCGATGTTCCGATACTGGCA	0.602													T	46406690	T	T	46406690	3	4	96	1	0	0	0	0	1	0	0	0	3379	652	23	2	25	2	CHRM4	11	46406690	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	456412	46406690	88599826	139	6531											
P2RX3	5024	broad.mit.edu	37	chr11	57137380	57137380	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	aatgagactacgctgaaaatCgcggctttgaccaacccagt	9	11	0	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:57137380C>A	uc001nju.2	+	12	1180	c.1104C>A	c.(1102-1104)ATC>ATA	p.I368I		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	368	Cytoplasmic (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						CGCTGAAAATCGCGGCTTTGA	0.547													A	57137380	A	A	57137380	2	1	96	1	0	0	0	0	0	0	0	1	11341	874	31	5		5	P2RX3	11	57137380	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	10730690	57137380	77869136	140	6532											
RASGRP2	10235	broad.mit.edu	37	chr11	64496457	64496457	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctcacactctgggccctgCgccgacactcaactgacagg	11	16	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:64496457C>T	uc009ypu.2	-	15	1876	c.1649G>A	c.(1648-1650)CGC>CAC	p.R550H	RASGRP2_uc001oat.2_Missense_Mutation_p.R452H|RASGRP2_uc001oau.2_Missense_Mutation_p.R405H|RASGRP2_uc009ypv.2_Missense_Mutation_p.R550H|RASGRP2_uc009ypw.2_Missense_Mutation_p.R550H	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	550					platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						CTGGGCCCTGCGCCGACACTC	0.637													T	64496457	T	T	64496457	3	4	96	1	0	0	0	0	1	0	0	0	13075	768	27	1	188	1	RASGRP2	11	64496457	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	7359077	64496457	70510059	141	6533											
INPPL1	3636	broad.mit.edu	37	chr11	71942122	71942123	+	Frame_Shift_Ins	INS	-	C	C													acgaggtcacagtgaccataINSccccatgacatctatgtctt							TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:71942122_71942123insC	uc001osf.2	+	12	1533_1534	c.1386_1387insC	c.(1384-1389)ATACCCfs	p.I462fs	INPPL1_uc001osg.2_Frame_Shift_Ins_p.I220fs	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	462_463					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						CAGTGACCATACCCCATGACAT	0.579													C	71942123	C	C	71942122	7	5	96	1	0	1	1	0	0	0	0	0	7761	381	14	0	1432	0	INPPL1	11	71942122	Frame_Shift_Ins	INS	-	TCGA-06-5858-01A-01D-1696-08	7445665	71942122	63064394	142	6534											
INPPL1	3636	broad.mit.edu	37	chr11	71943788	71943788	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtttggggacctcaactacCgcctggacatggatatccag	12	11	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:71943788C>T	uc001osf.2	+	15	1978	c.1831C>T	c.(1831-1833)CGC>TGC	p.R611C	INPPL1_uc001osg.2_Missense_Mutation_p.R369C	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	611					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						CCTCAACTACCGCCTGGACAT	0.612													T	71943788	T	T	71943788	3	4	96	1	0	0	0	0	1	0	0	0	7761	652	23	2	1889	2	INPPL1	11	71943788	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	1666	71943788	63062728	143	6535											
ATG16L2	89849	broad.mit.edu	37	chr11	72528883	72528883	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggaggaggaggaggggctcCggctggtctgtggtgaggta	22	5	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:72528883C>T	uc001otd.2	+	3	341	c.301C>T	c.(301-303)CGG>TGG	p.R101W	ATG16L2_uc001otc.1_Missense_Mutation_p.R101W|ATG16L2_uc010rrf.1_Missense_Mutation_p.R101W|ATG16L2_uc001ote.2_5'UTR|ATG16L2_uc009ytj.1_Missense_Mutation_p.R101W	NM_033388	NP_203746	Q8NAA4	A16L2_HUMAN	ATG16 autophagy related 16-like 2	101					autophagy|protein transport	cytoplasm	protein binding				0			BRCA - Breast invasive adenocarcinoma(5;2.73e-06)			GGAGGGGCTCCGGCTGGTCTG	0.577													T	72528883	T	T	72528883	3	4	96	1	0	0	0	0	1	0	0	0	1092	643	23	2	311	2	ATG16L2	11	72528883	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	585095	72528883	62477633	144	6536											
RNF26	79102	broad.mit.edu	37	chr11	119206097	119206097	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtgtactctgctgtatAgctgctgctctggcctagag	11	11	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:119206097A>G	uc001pwh.2	+	1	861	c.265A>G	c.(265-267)AGC>GGC	p.S89G		NM_032015	NP_114404	Q9BY78	RNF26_HUMAN	ring finger protein 26	89	Leu-rich.						zinc ion binding			ovary(1)	1		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)		TCTGCTGTATAGCTGCTGCTC	0.607													G	119206097	G	G	119206097	3	3	96	1	0	0	0	0	1	0	0	0	13486	420	15	4	267	4	RNF26	11	119206097	Missense_Mutation	SNP	A	TCGA-06-5858-01A-01D-1696-08	46677214	119206097	15800419	145	6537											
TMEM136	219902	broad.mit.edu	37	chr11	120201174	120201174	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accatgcttggagaagcaggCggagtgaggaacggcagctg	17	8	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:120201174C>T	uc001pxh.1	+	3	751	c.688C>T	c.(688-690)CGG>TGG	p.R230W	TMEM136_uc001pxg.2_Missense_Mutation_p.R133W|TMEM136_uc010rzm.1_Missense_Mutation_p.R111W|TMEM136_uc001pxj.2_Missense_Mutation_p.R252W|TMEM136_uc009zas.1_Missense_Mutation_p.R116W|TMEM136_uc001pxi.1_Missense_Mutation_p.R116W	NM_174926	NP_777586	Q6ZRR5	TM136_HUMAN	transmembrane protein 136	230						integral to membrane				ovary(1)	1		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Hepatocellular(160;0.206)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.07e-06)		GAGAAGCAGGCGGAGTGAGGA	0.493													T	120201174	T	T	120201174	3	4	96	1	0	0	0	0	1	0	0	0	16049	759	27	1	407	1	TMEM136	11	120201174	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	995077	120201174	14805342	146	6538											
FOXRED1	55572	broad.mit.edu	37	chr11	126143242	126143242	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcacacaggagtacctggcCgtagtcgatgctcctcccct	10	15	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:126143242C>T	uc001qdi.2	+	4	476	c.429C>T	c.(427-429)GCC>GCT	p.A143A	FOXRED1_uc010sbn.1_5'UTR|FOXRED1_uc010sbo.1_RNA|FOXRED1_uc010sbp.1_5'UTR|FOXRED1_uc010sbq.1_Missense_Mutation_p.R12C|FOXRED1_uc001qdj.2_5'UTR|FOXRED1_uc010sbr.1_Silent_p.A129A|FOXRED1_uc001qdk.2_5'UTR	NM_017547	NP_060017	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing	143						integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		AGTACCTGGCCGTAGTCGATG	0.557													T	126143242	T	T	126143242	2	4	96	1	0	0	0	0	0	0	0	1	6033	639	23	2		2	FOXRED1	11	126143242	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	5942068	126143242	8863274	147	6539											
ADAMTS15	170689	broad.mit.edu	37	chr11	130343095	130343095	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacgggcatttcgtggtgtcGgcggtggagcgggacctggt	19	8	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr11:130343095G>A	uc010scd.1	+	8	2232	c.2232G>A	c.(2230-2232)TCG>TCA	p.S744S		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	744	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		TCGTGGTGTCGGCGGTGGAGC	0.642													A	130343095	A	A	130343095	2	1	96	1	0	0	0	0	0	0	0	1	260	1103	39	2		2	ADAMTS15	11	130343095	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	4199853	130343095	4663421	148	6540											
WBP11	51729	broad.mit.edu	37	chr12	14946750	14946750	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttctccatctgatttgtcGgtgtcactgtcatcagtact	7	11	5	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr12:14946750G>A	uc001rci.2	-	8	989	c.828C>T	c.(826-828)ACC>ACT	p.T276T		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	276	Asp-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						CTGATTTGTCGGTGTCACTGT	0.433													A	14946750	A	A	14946750	2	1	96	1	0	0	0	0	0	0	0	1	17255	1103	39	2		2	WBP11	12	14946750	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08		14946750	118905145	149	6541											
TXNRD1	7296	broad.mit.edu	37	chr12	104714974	104714974	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgctggtattggtttagaCgtcactgttatggttaggtc	12	6	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr12:104714974C>T	uc010swk.1	+	10	1117	c.1095C>T	c.(1093-1095)GAC>GAT	p.D365D	TXNRD1_uc010swl.1_Silent_p.D215D|TXNRD1_uc010swm.1_Silent_p.D267D|TXNRD1_uc010swn.1_Silent_p.D215D|TXNRD1_uc010swo.1_Silent_p.D215D|TXNRD1_uc010swp.1_Silent_p.D177D|TXNRD1_uc010swq.1_Silent_p.D265D|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Silent_p.D281D	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	365				D -> N (in Ref. 3; AAC69621).	cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						TTGGTTTAGACGTCACTGTTA	0.448													T	104714974	T	T	104714974	2	4	96	1	0	0	0	0	0	0	0	1	16804	535	19	1		1	TXNRD1	12	104714974	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	89768224	104714974	29136921	150	6542											
ULK1	8408	broad.mit.edu	37	chr12	132397780	132397780	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcccagtgccaaacccccGccagacagcctgatgtgcag	11	17	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr12:132397780G>A	uc001uje.2	+	14	1402	c.1134G>A	c.(1132-1134)CCG>CCA	p.P378P		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	378	Interaction with GABARAP and GABARAPL2.				autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CCAAACCCCCGCCAGACAGCC	0.617													A	132397780	A	A	132397780	2	1	96	1	0	0	0	0	0	0	0	1	16972	1074	38	1		1	ULK1	12	132397780	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	27682806	132397780	1454115	151	6543											
TPTE2	93492	broad.mit.edu	37	chr13	20067042	20067042	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttaaattcacttgtgtgtgGgctagaggatgataaaagaa	11	3	1	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr13:20067042G>A	uc001umd.2	-	4	278	c.67C>T	c.(67-69)CCA>TCA	p.P23S	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.P23S|TPTE2_uc001ume.2_Missense_Mutation_p.P23S|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	23						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CTTGTGTGTGGGCTAGAGGAT	0.353													A	20067042	A	A	20067042	3	1	96	1	0	0	0	0	1	0	0	0	16428	1246	43	3	1573	3	TPTE2	13	20067042	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		20067042	95102836	152	6544											
PARP4	143	broad.mit.edu	37	chr13	25023906	25023906	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attaaaatattcaaatactcCggcaccacactgggacaaaa	5	10	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr13:25023906C>T	uc001upl.2	-	25	3170	c.3064G>A	c.(3064-3066)GGA>AGA	p.G1022R		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1022	VWFA.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TCAAATACTCCGGCACCACAC	0.308													T	25023906	T	T	25023906	3	4	96	1	0	0	0	0	1	0	0	0	11463	661	23	2	2150	2	PARP4	13	25023906	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	4956864	25023906	90145972	153	6545											
STARD13	90627	broad.mit.edu	37	chr13	33704214	33704214	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgctgcctccactgctttcGctgtgaatggagcagacctc	10	14	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr13:33704214G>A	uc001uuw.2	-	5	726	c.600C>T	c.(598-600)AGC>AGT	p.S200S	STARD13_uc001uuu.2_Silent_p.S192S|STARD13_uc001uuv.2_Silent_p.S82S|STARD13_uc001uux.2_Silent_p.S165S|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Silent_p.S185S	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	200					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		CACTGCTTTCGCTGTGAATGG	0.627													A	33704214	A	A	33704214	2	1	96	1	0	0	0	0	0	0	0	1	15255	1078	38	1		1	STARD13	13	33704214	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	8680308	33704214	81465664	154	6546											
RB1	5925	broad.mit.edu	37	chr13	48947629	48947629	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctgatttcctattttaacGtaagccatatatgaaacatt	4	7	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr13:48947629G>A	uc001vcb.2	+	12	1381	c.1215_splice	c.e12+1	p.N405_splice	RB1_uc010act.1_Splice_Site_p.N106_splice	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(14)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTATTTTAACGTAAGCCATAT	0.264		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			A	48947629	A	A	48947629	5	1	96	1	0	0	0	0	0	0	1	0	13098	1159	40	1	1262	1	RB1	13	48947629	Splice_Site	SNP	G	TCGA-06-5858-01A-01D-1696-08	15243415	48947629	66222249	155	6547											
TGDS	23483	broad.mit.edu	37	chr13	95233375	95233375	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcccagtaagactgtacaaaAcattcagcagctgctttaga	7	10	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr13:95233375A>C	uc001vlw.2	-	6	646	c.525T>G	c.(523-525)TGT>TGG	p.C175W	TGDS_uc001vlx.2_RNA	NM_014305	NP_055120	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	175					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					ACTGTACAAAACATTCAGCAG	0.318													C	95233375	C	C	95233375	3	2	96	1	0	0	0	0	1	0	0	0	15811	41	2	5	555	5	TGDS	13	95233375	Missense_Mutation	SNP	A	TCGA-06-5858-01A-01D-1696-08	46285746	95233375	19936503	156	6548											
ABCC4	10257	broad.mit.edu	37	chr13	95673860	95673860	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctcgaaaatagttaaggtcGagggctgtccattggaagtg	13	6	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr13:95673860G>A	uc001vmd.3	-	31	4066	c.3947C>T	c.(3946-3948)TCG>TTG	p.S1316L	ABCC4_uc010afj.2_Missense_Mutation_p.S107L|ABCC4_uc010afk.2_Missense_Mutation_p.S1269L	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	1316					platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	AGTTAAGGTCGAGGGCTGTCC	0.383													A	95673860	A	A	95673860	3	1	96	1	0	0	0	0	1	0	0	0	55	1059	37	2	34	2	ABCC4	13	95673860	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	440485	95673860	19496018	157	6549											
COL4A2	1284	broad.mit.edu	37	chr13	111088642	111088642	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagggcagccgggacccaaCgggattccatcagacaccct	12	14	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr13:111088642C>T	uc001vqx.2	+	13	1042	c.753C>T	c.(751-753)AAC>AAT	p.N251N		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	251	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CGGGACCCAACGGGATTCCAT	0.463													T	111088642	T	T	111088642	2	4	96	1	0	0	0	0	0	0	0	1	3690	535	19	1		1	COL4A2	13	111088642	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	15414782	111088642	4081236	158	6550											
ING1	3621	broad.mit.edu	37	chr13	111371669	111371669	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcactgtgtgcagcgcgCgctgatccgcagccaggagc	15	14	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr13:111371669C>T	uc001vri.2	+	2	1091	c.659C>T	c.(658-660)GCG>GTG	p.A220V	ING1_uc001vrf.2_Missense_Mutation_p.A33V|ING1_uc001vrg.2_Missense_Mutation_p.A8V|ING1_uc001vrh.2_Missense_Mutation_p.A77V	NM_005537	NP_005528	Q9UK53	ING1_HUMAN	inhibitor of growth family, member 1 isoform D	220					cell cycle|negative regulation of cell growth|negative regulation of cell proliferation	nucleus	zinc ion binding			ovary(1)	1	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.188)			GTGCAGCGCGCGCTGATCCGC	0.652													T	111371669	T	T	111371669	3	4	96	1	0	0	0	0	1	0	0	0	7735	768	27	1	813	1	ING1	13	111371669	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	283027	111371669	3798209	159	6551											
ARHGEF7	8874	broad.mit.edu	37	chr13	111870210	111870210	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttccccagcaactacgtgcGcgaggtcaaggccagcggta	13	13	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr13:111870210G>A	uc001vrs.2	+	6	966	c.716G>A	c.(715-717)CGC>CAC	p.R239H	ARHGEF7_uc001vrr.2_Missense_Mutation_p.R218H|ARHGEF7_uc001vrt.2_Missense_Mutation_p.R189H|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Missense_Mutation_p.R61H|ARHGEF7_uc001vrv.3_Missense_Mutation_p.R61H|ARHGEF7_uc001vrw.3_Missense_Mutation_p.R61H|ARHGEF7_uc001vrx.3_Missense_Mutation_p.R61H|ARHGEF7_uc010tjo.1_Missense_Mutation_p.R136H	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	239	SH3.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			AACTACGTGCGCGAGGTCAAG	0.567													A	111870210	A	A	111870210	3	1	96	1	0	0	0	0	1	0	0	0	911	1087	38	1	738	1	ARHGEF7	13	111870210	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	498541	111870210	3299668	160	6552											
SDCCAG1	9147	broad.mit.edu	37	chr14	50267402	50267402	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttatcctcatcactgctcGtgtcacctccatctgtagaa	5	14	4	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr14:50267402G>A	uc001wxc.2	-	23	2176	c.2108C>T	c.(2107-2109)ACG>ATG	p.T703M	SDCCAG1_uc010anj.1_Missense_Mutation_p.T703M|SDCCAG1_uc001wwz.2_5'Flank|SDCCAG1_uc001wxa.2_Translation_Start_Site|SDCCAG1_uc010tqi.1_Missense_Mutation_p.T682M|SDCCAG1_uc001wxe.2_Missense_Mutation_p.T661M|SDCCAG1_uc001wxd.1_Missense_Mutation_p.T108M	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	703						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		ATCACTGCTCGTGTCACCTCC	0.413													A	50267402	A	A	50267402	3	1	96	1	0	0	0	0	1	0	0	0	13957	1145	40	1	1166	1	SDCCAG1	14	50267402	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		50267402	57082138	161	6553											
BMP4	652	broad.mit.edu	37	chr14	54418835	54418835	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcgtggccctgaatctcggCgacttttttcttccccgtct	9	15	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr14:54418835C>T	uc001xal.3	-	2	293	c.106G>A	c.(106-108)GCC>ACC	p.A36T	BMP4_uc010aoh.2_Missense_Mutation_p.A36T|BMP4_uc001xao.3_Missense_Mutation_p.A36T|BMP4_uc001xan.3_Missense_Mutation_p.A36T	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	36					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						TGAATCTCGGCGACTTTTTTC	0.582													T	54418835	T	T	54418835	3	4	96	1	0	0	0	0	1	0	0	0	1462	768	27	1	1128	1	BMP4	14	54418835	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	4151433	54418835	52930705	162	6554											
PLEKHG3	26030	broad.mit.edu	37	chr14	65208866	65208866	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccactgaggggcgcagcccGgcccacctggcccgggagct	15	18	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr14:65208866G>A	uc001xho.1	+	16	2900	c.2631G>A	c.(2629-2631)CCG>CCA	p.P877P	PLEKHG3_uc001xhn.1_Silent_p.P821P|PLEKHG3_uc001xhp.2_Silent_p.P998P|PLEKHG3_uc010aqh.1_Silent_p.P419P|PLEKHG3_uc001xhq.1_Silent_p.P382P	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	877					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		GGCGCAGCCCGGCCCACCTGG	0.667													A	65208866	A	A	65208866	2	1	96	1	0	0	0	0	0	0	0	1	12070	1103	39	2		2	PLEKHG3	14	65208866	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	10790031	65208866	42140674	163	6555											
ADCK1	57143	broad.mit.edu	37	chr14	78390916	78390916	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccccggcacgggaaaggcGgagattgtcctgttggacca	14	12	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr14:78390916G>A	uc001xui.2	+	8	1074	c.975G>A	c.(973-975)GCG>GCA	p.A325A	ADCK1_uc010tvo.1_RNA|ADCK1_uc001xuj.2_Silent_p.A257A|ADCK1_uc001xuk.1_Silent_p.A199A|ADCK1_uc001xul.2_Silent_p.A32A	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	332	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		CGGGAAAGGCGGAGATTGTCC	0.557													A	78390916	A	A	78390916	2	1	96	1	0	0	0	0	0	0	0	1	288	1103	39	2		2	ADCK1	14	78390916	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	13182050	78390916	28958624	164	6556											
EML5	161436	broad.mit.edu	37	chr14	89160659	89160659	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcactttcttacctgctttaCgccaaaatttcatgtgttta	5	10	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr14:89160659C>T	uc001xxg.2	-	18	2717	c.2531G>A	c.(2530-2532)CGT>CAT	p.R844H	EML5_uc001xxh.1_Missense_Mutation_p.R21H	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	844	WD 13.					cytoplasm|microtubule				ovary(3)	3						ACCTGCTTTACGCCAAAATTT	0.259													T	89160659	T	T	89160659	3	4	96	1	0	0	0	0	1	0	0	0	5100	536	19	1	3510	1	EML5	14	89160659	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	10769743	89160659	18188881	165	6557											
RIN3	79890	broad.mit.edu	37	chr14	93119291	93119291	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcctggagatgatggcgCgccagacctccagcacggag	14	13	0	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr14:93119291C>T	uc001yap.2	+	6	2049	c.1897C>T	c.(1897-1899)CGC>TGC	p.R633C	RIN3_uc010auk.2_Missense_Mutation_p.R295C|RIN3_uc001yaq.2_Missense_Mutation_p.R558C|RIN3_uc001yar.1_Missense_Mutation_p.R295C|RIN3_uc001yas.1_Missense_Mutation_p.R295C	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	633	Interaction with RAB5B.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				GATGATGGCGCGCCAGACCTC	0.597													T	93119291	T	T	93119291	3	4	96	1	0	0	0	0	1	0	0	0	13373	768	27	1	1919	1	RIN3	14	93119291	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	3958632	93119291	14230249	166	6558											
SERPINA5	5104	broad.mit.edu	37	chr14	95058444	95058444	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtcgggaaccagagcagcGgcagccacggggacaatatt	15	10	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr14:95058444G>A	uc001ydm.2	+	6	1299	c.1089G>A	c.(1087-1089)GCG>GCA	p.A363A	SERPINA3_uc001ydo.3_5'UTR	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	363					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CCAGAGCAGCGGCAGCCACGG	0.567													A	95058444	A	A	95058444	2	1	96	1	0	0	0	0	0	0	0	1	14092	1103	39	2		2	SERPINA5	14	95058444	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	1939153	95058444	12291096	167	6559											
C14orf49	161176	broad.mit.edu	37	chr14	95922000	95922000	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtgttccgaatgacacccGcagactgctcctccagcgtc	10	15	0	2	rs143391386		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr14:95922000G>A	uc001yei.3	-	5	866	c.851C>T	c.(850-852)GCG>GTG	p.A284V	C14orf49_uc010avi.2_Missense_Mutation_p.A284V|C14orf49_uc001yej.1_Missense_Mutation_p.A284V	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	284	Spectrin 1.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		AATGACACCCGCAGACTGCTC	0.567													A	95922000	A	A	95922000	3	1	96	1	0	0	0	0	1	0	0	0	1776	1087	38	1	2128	1	C14orf49	14	95922000	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	863556	95922000	11427540	168	6560											
CDC42BPB	9578	broad.mit.edu	37	chr14	103412980	103412980	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttctgtcagaatgagcagCgagctggtcttagaaggtgc	13	7	3	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr14:103412980C>T	uc001ymi.1	-	28	3805	c.3573G>A	c.(3571-3573)TCG>TCA	p.S1191S	CDC42BPB_uc001ymj.1_Silent_p.S293S	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1191	PH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GAATGAGCAGCGAGCTGGTCT	0.488													T	103412980	T	T	103412980	2	4	96	1	0	0	0	0	0	0	0	1	3073	755	27	1		1	CDC42BPB	14	103412980	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	7490980	103412980	3936560	169	6561											
HERC2	8924	broad.mit.edu	37	chr15	28421858	28421858	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcggtcagagccagggtctgCgcgtctctactcccacatgc	11	15	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:28421858C>T	uc001zbj.2	-	62	9595	c.9489G>A	c.(9487-9489)GCG>GCA	p.A3163A		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3163	RCC1 9.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CCAGGGTCTGCGCGTCTCTAC	0.493													T	28421858	T	T	28421858	2	4	96	1	0	0	0	0	0	0	0	1	7058	755	27	1		1	HERC2	15	28421858	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08		28421858	74109534	170	6562											
SPTBN5	51332	broad.mit.edu	37	chr15	42151139	42151139	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgccggagctcctccaggcgAtggcggcgggtcccggcttg	17	14	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:42151139A>G	uc001zos.2	-	48	8256	c.7923T>C	c.(7921-7923)CAT>CAC	p.H2641H		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2676	Spectrin 23.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CCTCCAGGCGATGGCGGCGGG	0.706													G	42151139	G	G	42151139	2	3	96	1	0	0	0	0	0	0	0	1	15121	330	12	4		4	SPTBN5	15	42151139	Silent	SNP	A	TCGA-06-5858-01A-01D-1696-08	13729281	42151139	60380253	171	6563											
SLC27A2	11001	broad.mit.edu	37	chr15	50528151	50528151	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactggaacttttaaacaccGcaaaatgaccctggtggagg	10	10	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:50528151G>A	uc001zxw.2	+	10	1953	c.1721G>A	c.(1720-1722)CGC>CAC	p.R574H	SLC27A2_uc010bes.2_Missense_Mutation_p.R521H|SLC27A2_uc001zxx.2_Missense_Mutation_p.R339H	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	574	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		TTTAAACACCGCAAAATGACC	0.418													A	50528151	A	A	50528151	3	1	96	1	0	0	0	0	1	0	0	0	14526	1087	38	1	1759	1	SLC27A2	15	50528151	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	8377012	50528151	52003241	172	6564											
ARID3B	10620	broad.mit.edu	37	chr15	74888087	74888087	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcccggggcacccccagcgCagagccctccaccagctggt	11	19	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:74888087C>T	uc002aye.2	+	9	1859	c.1658C>T	c.(1657-1659)GCA>GTA	p.A553V	ARID3B_uc002ayd.2_Missense_Mutation_p.A552V|CLK3_uc002ayf.1_5'Flank	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	553	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						ACCCCCAGCGCAGAGCCCTCC	0.522													T	74888087	T	T	74888087	3	4	96	1	0	0	0	0	1	0	0	0	917	710	25	3	1685	3	ARID3B	15	74888087	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	24359936	74888087	27643305	173	6565											
COMMD4	54939	broad.mit.edu	37	chr15	75631625	75631625	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcacgcggccagcctgtgcCgctgttatgaggagaagcaa	14	11	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:75631625C>T	uc002azy.2	+	6	379	c.322C>T	c.(322-324)CGC>TGC	p.R108C	COMMD4_uc010umf.1_3'UTR|COMMD4_uc002azz.2_Silent_p.A90A|COMMD4_uc002baa.2_Missense_Mutation_p.R108C|COMMD4_uc010umg.1_3'UTR|COMMD4_uc010umh.1_RNA	NM_017828	NP_060298	Q9H0A8	COMD4_HUMAN	COMM domain containing 4	108						cytoplasm	protein binding				0						CAGCCTGTGCCGCTGTTATGA	0.612													T	75631625	T	T	75631625	3	4	96	1	0	0	0	0	1	0	0	0	3718	652	23	2	344	2	COMMD4	15	75631625	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	743538	75631625	26899767	174	6566											
SIN3A	25942	broad.mit.edu	37	chr15	75722661	75722661	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctctgtgctgccagggatcCgacgctgctgggctgcatac	13	14	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:75722661C>T	uc002bai.2	-	2	315	c.56G>A	c.(55-57)CGG>CAG	p.R19Q	SIN3A_uc002baj.2_Missense_Mutation_p.R19Q|SIN3A_uc010uml.1_Missense_Mutation_p.R19Q|SIN3A_uc002bak.3_Missense_Mutation_p.R19Q	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	19					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						GCCAGGGATCCGACGCTGCTG	0.577													T	75722661	T	T	75722661	3	4	96	1	0	0	0	0	1	0	0	0	14325	652	23	2	3845	2	SIN3A	15	75722661	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	91036	75722661	26808731	175	6567											
WDR61	80349	broad.mit.edu	37	chr15	78578420	78578420	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcatcaggacagaatgcaaCgttcagcacccaggaggcat	11	11	3	1	rs148690647	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:78578420C>T	uc002bdn.2	-	9	788	c.712G>A	c.(712-714)GTT>ATT	p.V238I	WDR61_uc002bdo.2_Missense_Mutation_p.V238I	NM_025234	NP_079510	Q9GZS3	WDR61_HUMAN	WD repeat domain 61	238	WD 6.						protein binding			ovary(1)|skin(1)	2						CAGAATGCAACGTTCAGCACC	0.433													T	78578420	T	T	78578420	3	4	96	1	0	0	0	0	1	0	0	0	17309	536	19	1	217	1	WDR61	15	78578420	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	2855759	78578420	23952972	176	6568											
MESDC1	59274	broad.mit.edu	37	chr15	81295114	81295114	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcagggttgcgccgtgctgCgcgccacgccgctggccgac	16	16	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:81295114C>T	uc002bfz.2	+	1	1820	c.502C>T	c.(502-504)CGC>TGC	p.R168C		NM_022566	NP_072088	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	168											0						CGCCGTGCTGCGCGCCACGCC	0.746													T	81295114	T	T	81295114	3	4	96	1	0	0	0	0	1	0	0	0	9480	768	27	1	504	1	MESDC1	15	81295114	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	2716694	81295114	21236278	177	6569											
WDR73	84942	broad.mit.edu	37	chr15	85189474	85189474	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgcagacttcggagcctcGccccatggaggactccgggt	13	15	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:85189474G>A	uc002bkw.2	-	6	474	c.458C>T	c.(457-459)GCG>GTG	p.A153V	WDR73_uc002bkv.2_RNA|WDR73_uc002bkx.2_RNA|WDR73_uc010upa.1_Missense_Mutation_p.A153V|uc002bky.1_3'UTR	NM_032856	NP_116245	Q6P4I2	WDR73_HUMAN	WD repeat domain 73	153											0						TCGGAGCCTCGCCCCATGGAG	0.582													A	85189474	A	A	85189474	3	1	96	1	0	0	0	0	1	0	0	0	17320	1087	38	1	690	1	WDR73	15	85189474	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	3894360	85189474	17341918	178	6570											
LRRK1	79705	broad.mit.edu	37	chr15	101567914	101567914	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccgcagccgggacgacgaCgtgcagtacctgacggacag	15	14	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr15:101567914C>T	uc002bwr.2	+	19	2917	c.2598C>T	c.(2596-2598)GAC>GAT	p.D866D	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	866					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GGGACGACGACGTGCAGTACC	0.667													T	101567914	T	T	101567914	2	4	96	1	0	0	0	0	0	0	0	1	9032	535	19	1		1	LRRK1	15	101567914	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	16378440	101567914	963478	179	6571											
HS3ST2	9956	broad.mit.edu	37	chr16	22926622	22926622	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcgactcatcactgacccGgccggcgagatggggcgagt	16	12	2	2	rs148264643		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr16:22926622G>A	uc002dli.2	+	2	915	c.843G>A	c.(841-843)CCG>CCA	p.P281P	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	281	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		TCACTGACCCGGCCGGCGAGA	0.552													A	22926622	A	A	22926622	2	1	96	1	0	0	0	0	0	0	0	1	7364	1103	39	2		2	HS3ST2	16	22926622	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08		22926622	67428131	180	6572											
C16orf54	283897	broad.mit.edu	37	chr16	29756241	29756241	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgcggggggcccctccacgCgcccagagggcggctctgga	17	15	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr16:29756241C>T	uc002dtp.2	-	2	141	c.32G>A	c.(31-33)CGC>CAC	p.R11H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002dtq.1_5'Flank	NM_175900	NP_787096	Q6UWD8	CP054_HUMAN	hypothetical protein LOC283897	11						integral to membrane					0						CCCCTCCACGCGCCCAGAGGG	0.652													T	29756241	T	T	29756241	3	4	96	1	0	0	0	0	1	0	0	0	1819	768	27	1	646	1	C16orf54	16	29756241	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	6829619	29756241	60598512	181	6573											
ZNF689	115509	broad.mit.edu	37	chr16	30616193	30616193	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgagggccgtgcgctggcGgaagcggcggttgcactcga	19	11	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr16:30616193G>A	uc002dyx.2	-	3	1215	c.895C>T	c.(895-897)CGC>TGC	p.R299C	ZNF689_uc010bzy.2_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	299	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GTGCGCTGGCGGAAGCGGCGG	0.672													A	30616193	A	A	30616193	3	1	96	1	0	0	0	0	1	0	0	0	18091	1116	39	2	611	2	ZNF689	16	30616193	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	859952	30616193	59738560	182	6574											
FBXL19	54620	broad.mit.edu	37	chr16	30958480	30958480	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcacccgaagcttgtgccCggctggcagctgccgggccc	13	17	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr16:30958480C>T	uc002eab.2	+	11	2172	c.2014C>T	c.(2014-2016)CGG>TGG	p.R672W	FBXL19_uc002dzz.1_Missense_Mutation_p.R360W|FBXL19_uc002eaa.1_Missense_Mutation_p.R571W|ORAI3_uc002eac.2_5'Flank	NM_001099784	NP_001093254	Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	672	LRR 6.						DNA binding|zinc ion binding			ovary(2)|lung(1)|breast(1)	4						AGCTTGTGCCCGGCTGGCAGC	0.711													T	30958480	T	T	30958480	3	4	96	1	0	0	0	0	1	0	0	0	5715	643	23	2	2056	2	FBXL19	16	30958480	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	342287	30958480	59396273	183	6575											
CCDC102A	92922	broad.mit.edu	37	chr16	57546730	57546730	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggcctcctcggtgccaaagcGagcactgcggatcttcccga	12	15	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr16:57546730G>A	uc002elw.2	-	9	1789	c.1576C>T	c.(1576-1578)CGC>TGC	p.R526C		NM_033212	NP_149989	Q96A19	C102A_HUMAN	coiled-coil domain containing 102A	526										ovary(1)	1						GTGCCAAAGCGAGCACTGCGG	0.637													A	57546730	A	A	57546730	3	1	96	1	0	0	0	0	1	0	0	0	2736	1058	37	2	80	2	CCDC102A	16	57546730	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	26588250	57546730	32808023	184	6576											
FAM65A	79567	broad.mit.edu	37	chr16	67578997	67578997	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtgcccgcctctccctgcGccagccaggcttggctgagg	14	16	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr16:67578997G>A	uc010vjp.1	+	17	3164	c.3068G>A	c.(3067-3069)CGC>CAC	p.R1023H	FAM65A_uc002eth.2_Missense_Mutation_p.R1003H|FAM65A_uc010cej.2_Missense_Mutation_p.R1006H|FAM65A_uc010vjq.1_Missense_Mutation_p.R1017H|FAM65A_uc002etk.2_Missense_Mutation_p.R1001H	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	1007						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CTCTCCCTGCGCCAGCCAGGC	0.627													A	67578997	A	A	67578997	3	1	96	1	0	0	0	0	1	0	0	0	5599	1087	38	1	3070	1	FAM65A	16	67578997	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	10032267	67578997	22775756	185	6577											
PKD1L2	114780	broad.mit.edu	37	chr16	81236192	81236192	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcctgactgggacaggccGgagcatgcagtcacactgag	14	12	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr16:81236192G>A	uc002fgh.1	-	6	1056	c.1056C>T	c.(1054-1056)TCC>TCT	p.S352S	PKD1L2_uc002fgj.2_Silent_p.S352S	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	352	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGGACAGGCCGGAGCATGCAG	0.582													A	81236192	A	A	81236192	2	1	96	1	0	0	0	0	0	0	0	1	11965	1103	39	2		2	PKD1L2	16	81236192	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	13657195	81236192	9118561	186	6578											
SLC7A5	8140	broad.mit.edu	37	chr16	87873310	87873310	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcgggtagcggctcaccaCggccacggcctcggacgaca	15	15	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr16:87873310C>T	uc002fkm.2	-	5	1009	c.937G>A	c.(937-939)GTG>ATG	p.V313M		NM_003486	NP_003477	Q01650	LAT1_HUMAN	solute carrier family 7 (cationic amino acid	313					blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding				0				BRCA - Breast invasive adenocarcinoma(80;0.049)		CGGCTCACCACGGCCACGGCC	0.662													T	87873310	T	T	87873310	3	4	96	1	0	0	0	0	1	0	0	0	14700	536	19	1	610	1	SLC7A5	16	87873310	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	6637118	87873310	2481443	187	6579											
RPA1	6117	broad.mit.edu	37	chr17	1780602	1780602	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctccctagaactggttgaCgaaagtgtgagtgtttgtca	11	7	2	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:1780602C>T	uc002fto.2	+	8	799	c.684C>T	c.(682-684)GAC>GAT	p.D228D		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	228					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						AACTGGTTGACGAAAGTGTGA	0.562								NER					T	1780602	T	T	1780602	2	4	96	1	0	0	0	0	0	0	0	1	13536	535	19	1		1	RPA1	17	1780602	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08		1780602	79414608	188	6580											
PLD2	5338	broad.mit.edu	37	chr17	4713214	4713214	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcctgctgtacatgtgcctCgagacaggtgccatctcatt	9	12	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:4713214C>T	uc002fzc.2	+	9	851	c.750C>T	c.(748-750)CTC>CTT	p.L250L	PLD2_uc010vsj.1_Silent_p.L107L|PLD2_uc002fzd.2_Silent_p.L250L	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	250	PH.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	ACATGTGCCTCGAGACAGGTG	0.562													T	4713214	T	T	4713214	2	4	96	1	0	0	0	0	0	0	0	1	12046	871	31	2		2	PLD2	17	4713214	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	2932612	4713214	76481996	189	6581											
WSCD1	23302	broad.mit.edu	37	chr17	6023636	6023636	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcctcactctagagtggccGgactttgtcaacagctacgc	10	13	3	1	rs146617432		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:6023636G>A	uc010cli.2	+	9	1762	c.1383G>A	c.(1381-1383)CCG>CCA	p.P461P	WSCD1_uc002gcn.2_Silent_p.P461P|WSCD1_uc002gco.2_Silent_p.P461P|WSCD1_uc010clj.2_Silent_p.P152P	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	461						integral to membrane	sulfotransferase activity				0						TAGAGTGGCCGGACTTTGTCA	0.672													A	6023636	A	A	6023636	2	1	96	1	0	0	0	0	0	0	0	1	17403	1103	39	2		2	WSCD1	17	6023636	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	1310422	6023636	75171574	190	6582											
DLG4	1742	broad.mit.edu	37	chr17	7097030	7097030	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agctcagaaccgagtcttctCgacctggtgggaggtggggc	16	10	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:7097030C>T	uc002get.3	-	17	2877	c.1676G>A	c.(1675-1677)CGA>CAA	p.R559Q	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Missense_Mutation_p.R456Q|DLG4_uc010cly.2_Missense_Mutation_p.R513Q|DLG4_uc010vto.1_Missense_Mutation_p.R556Q	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	516					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						CGAGTCTTCTCGACCTGGTGG	0.612													T	7097030	T	T	7097030	3	4	96	1	0	0	0	0	1	0	0	0	4557	884	31	2	651	2	DLG4	17	7097030	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	1073394	7097030	74098180	191	6583											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	13	14	3	0	rs28934578		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578406	T	T	7578406	3	4	96	1	0	0	0	0	1	0	0	0	16378	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	481376	7578406	73616804	192	6584											
KDM6B	23135	broad.mit.edu	37	chr17	7752152	7752152	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcaggtgctaccgccctgcCgcccacctcagcggccccta	9	20	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:7752152C>T	uc002giw.1	+	11	2922	c.2546C>T	c.(2545-2547)CCG>CTG	p.P849L	KDM6B_uc002gix.2_Missense_Mutation_p.P151L	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	849	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						ACCGCCCTGCCGCCCACCTCA	0.687													T	7752152	T	T	7752152	3	4	96	1	0	0	0	0	1	0	0	0	8138	652	23	2	2576	2	KDM6B	17	7752152	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	173746	7752152	73443058	193	6585											
C17orf76	388341	broad.mit.edu	37	chr17	16347362	16347362	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgtaggtagctggtcaccCgctccaggtctcgggaggtc	15	12	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:16347362C>T	uc010cph.1	-	4	751	c.575G>A	c.(574-576)CGG>CAG	p.R192Q	C17orf76_uc002gqh.2_Silent_p.A153A|NCRNA00188_uc010vwl.1_Intron|NCRNA00188_uc010vwm.1_Intron|NCRNA00188_uc010vwn.1_Intron|NCRNA00188_uc010cpe.2_Intron|NCRNA00188_uc010vwo.1_Intron|NCRNA00188_uc010vwp.1_Intron|C17orf76_uc002gqg.1_3'UTR	NM_001113567	NP_001107039	Q8NAA5	CQ076_HUMAN	hypothetical protein LOC388341 isoform 1	192											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)		GCTGGTCACCCGCTCCAGGTC	0.632													T	16347362	T	T	16347362	3	4	96	1	0	0	0	0	1	0	0	0	1881	652	23	2	463	2	C17orf76	17	16347362	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	8595210	16347362	64847848	194	6586											
NOS2	4843	broad.mit.edu	37	chr17	26116655	26116655	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtctccacgaggggctgcGgggactcattctgctgcttg	14	13	3	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:26116655G>A	uc002gzu.2	-	3	434	c.170C>T	c.(169-171)CCG>CTG	p.P57L	NOS2_uc010crh.1_Missense_Mutation_p.P57L|NOS2_uc010wab.1_Missense_Mutation_p.P57L	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	57					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GAGGGGCTGCGGGGACTCATT	0.537													A	26116655	A	A	26116655	3	1	96	1	0	0	0	0	1	0	0	0	10543	1116	39	2	3391	2	NOS2	17	26116655	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	9769293	26116655	55078555	195	6587											
SRCIN1	80725	broad.mit.edu	37	chr17	36704805	36704805	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgacctacctctagctctgcGatgatgcgatcctcgtcatc	8	14	3	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:36704805G>A	uc002hqd.2	-	17	3483	c.3258C>T	c.(3256-3258)ATC>ATT	p.I1086I	SRCIN1_uc002hqf.1_Silent_p.I958I|SRCIN1_uc002hqe.2_Silent_p.I940I	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	958				I -> L (in Ref. 6; AA sequence).	exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CTAGCTCTGCGATGATGCGAT	0.667													A	36704805	A	A	36704805	2	1	96	1	0	0	0	0	0	0	0	1	15135	1048	37	2		2	SRCIN1	17	36704805	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	10588150	36704805	44490405	196	6588											
SC65	10609	broad.mit.edu	37	chr17	39966036	39966036	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtagccacccacattgggggTcaaattggcctcacagtcca	10	13	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:39966036T>C	uc002hxt.2	-	4	1122	c.838A>G	c.(838-840)ACC>GCC	p.T280A	FKBP10_uc002hxv.2_5'Flank|SC65_uc002hxu.2_Missense_Mutation_p.T371A	NM_006455	NP_006446	Q92791	SC65_HUMAN	synaptonemal complex protein SC65	280					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.149)		ACATTGGGGGTCAAATTGGCC	0.562													C	39966036	C	C	39966036	3	2	96	1	0	0	0	0	1	0	0	0	13867	1667	58	4	495	4	SC65	17	39966036	Missense_Mutation	SNP	T	TCGA-06-5858-01A-01D-1696-08	3261231	39966036	41229174	197	6589											
BRCA1	672	broad.mit.edu	37	chr17	41243940	41243940	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctaatttcttggcccctcttCggtaaccctgagccaaatgt	7	13	2	1	rs55930959		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:41243940C>T	uc002icq.2	-	10	3840	c.3608G>A	c.(3607-3609)CGA>CAA	p.R1203Q	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.R1132Q|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.R1156Q|BRCA1_uc002ict.2_Missense_Mutation_p.R1203Q|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.R1203Q|BRCA1_uc002ide.1_Missense_Mutation_p.R1034Q|BRCA1_uc010cyy.1_Missense_Mutation_p.R1203Q|BRCA1_uc010whs.1_Missense_Mutation_p.R1203Q|BRCA1_uc010cyz.2_Missense_Mutation_p.R1156Q|BRCA1_uc010cza.2_Missense_Mutation_p.R1177Q|BRCA1_uc010wht.1_Missense_Mutation_p.R907Q	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1203					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGCCCCTCTTCGGTAACCCTG	0.433			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			T	41243940	T	T	41243940	3	4	96	1	0	0	0	0	1	0	0	0	1498	884	31	2	2109	2	BRCA1	17	41243940	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	1277904	41243940	39951270	198	6590											
MYCBPAP	84073	broad.mit.edu	37	chr17	48597088	48597088	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaccaagacaaaaactcagCgtggcctcatggagcccatc	9	13	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:48597088C>T	uc010wmr.1	+	7	1147	c.985C>T	c.(985-987)CGT>TGT	p.R329C	MYCBPAP_uc002iqx.2_Missense_Mutation_p.R329C|MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	292					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			AAAAACTCAGCGTGGCCTCAT	0.562													T	48597088	T	T	48597088	3	4	96	1	0	0	0	0	1	0	0	0	10019	768	27	1	1011	1	MYCBPAP	17	48597088	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	7353148	48597088	32598122	199	6591											
AMZ2	51321	broad.mit.edu	37	chr17	66246475	66246475	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagccagtgatctctttggAcccattaccttgcattctcc	6	15	2	1	rs138991707		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:66246475A>G	uc002jgs.1	+	3	264	c.147A>G	c.(145-147)GGA>GGG	p.G49G	AMZ2_uc002jgr.1_Silent_p.G49G|AMZ2_uc002jgt.1_Silent_p.G49G|AMZ2_uc002jgu.1_Silent_p.G49G|AMZ2_uc002jgv.1_Silent_p.G49G|AMZ2_uc002jgw.1_Silent_p.G49G|AMZ2_uc002jgx.1_Silent_p.G49G|AMZ2_uc002jgy.1_Silent_p.G49G	NM_001033572	NP_001028744	Q86W34	AMZ2_HUMAN	archaemetzincins-2 isoform 1	49							metallopeptidase activity|zinc ion binding				0	all_cancers(12;1.12e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATCTCTTTGGACCCATTACCT	0.458													G	66246475	G	G	66246475	2	3	96	1	0	0	0	0	0	0	0	1	597	262	10	4		4	AMZ2	17	66246475	Silent	SNP	A	TCGA-06-5858-01A-01D-1696-08	17649387	66246475	14948735	200	6592											
QRICH2	84074	broad.mit.edu	37	chr17	74287140	74287140	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttctccaagtcggtttggCcggcctgctcctcatccaga	9	15	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:74287140C>T	uc002jrd.1	-	4	3350	c.3170G>A	c.(3169-3171)GGC>GAC	p.G1057D	QRICH2_uc010wsz.1_Missense_Mutation_p.G983D|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1057							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						GTCGGTTTGGCCGGCCTGCTC	0.532													T	74287140	T	T	74287140	3	4	96	1	0	0	0	0	1	0	0	0	12880	739	26	3	1885	3	QRICH2	17	74287140	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	8040665	74287140	6908070	201	6593											
UBE2O	63893	broad.mit.edu	37	chr17	74395033	74395033	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagccatcctgccacatcacGtcggctgaggtcatcgtggt	12	13	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:74395033G>A	uc002jrm.3	-	10	1733	c.1668C>T	c.(1666-1668)GAC>GAT	p.D556D	UBE2O_uc002jrn.3_Silent_p.D556D|UBE2O_uc002jrl.3_Silent_p.D159D	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	556							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						GCCACATCACGTCGGCTGAGG	0.627													A	74395033	A	A	74395033	2	1	96	1	0	0	0	0	0	0	0	1	16865	1136	40	1		1	UBE2O	17	74395033	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	107893	74395033	6800177	202	6594											
AATK	9625	broad.mit.edu	37	chr17	79094804	79094804	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgagggaggtggagagccGtgtctcgggcccggggccct	19	11	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:79094804G>A	uc010dia.2	-	11	3012	c.2932C>T	c.(2932-2934)CGG>TGG	p.R978W	AATK_uc010dhz.2_Intron	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	978						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GTGGAGAGCCGTGTCTCGGGC	0.652													A	79094804	A	A	79094804	3	1	96	1	0	0	0	0	1	0	0	0	26	1144	40	1	1208	1	AATK	17	79094804	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	4699771	79094804	2100406	203	6595											
NPLOC4	55666	broad.mit.edu	37	chr17	79556036	79556036	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgtagccaagctccggggcGtccttgcatggcagcaaaca	13	13	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:79556036G>A	uc002kat.3	-	12	1397	c.1215C>T	c.(1213-1215)GAC>GAT	p.D405D	NPLOC4_uc002kau.3_Silent_p.D405D|NPLOC4_uc010wur.1_Silent_p.D244D	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	405					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GCTCCGGGGCGTCCTTGCATG	0.493													A	79556036	A	A	79556036	2	1	96	1	0	0	0	0	0	0	0	1	10586	1136	40	1		1	NPLOC4	17	79556036	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	461232	79556036	1639174	204	6596											
ARHGDIA	396	broad.mit.edu	37	chr17	79826780	79826780	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccagtccttcttgatggtgAgattccactcccaggacagg	10	12	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr17:79826780A>C	uc002kbp.2	-	5	626	c.587T>G	c.(586-588)CTC>CGC	p.L196R	ARHGDIA_uc002kjk.1_Missense_Mutation_p.L71R|ARHGDIA_uc002kbq.2_Missense_Mutation_p.L196R|ARHGDIA_uc002kbr.2_Missense_Mutation_p.S169A|ARHGDIA_uc002kbs.1_Intron|ARHGDIA_uc002kbt.1_Intron	NM_004309	NP_004300	P52565	GDIR1_HUMAN	Rho GDP dissociation inhibitor (GDI) alpha	196					anti-apoptosis|cellular component movement|negative regulation of axonogenesis|negative regulation of cell adhesion|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoskeleton|cytosol	GTPase activator activity|identical protein binding|Rho GDP-dissociation inhibitor activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CTTGATGGTGAGATTCCACTC	0.642													C	79826780	C	C	79826780	3	2	96	1	0	0	0	0	1	0	0	0	890	304	11	5	31	5	ARHGDIA	17	79826780	Missense_Mutation	SNP	A	TCGA-06-5858-01A-01D-1696-08	270744	79826780	1368430	205	6597											
MC2R	4158	broad.mit.edu	37	chr18	13885086	13885086	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcaccaccacagtgcggcgCatggtcacgatgctgtggta	13	12	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:13885086C>T	uc002ksp.1	-	2	609	c.432G>A	c.(430-432)ATG>ATA	p.M144I		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	144	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	CAGTGCGGCGCATGGTCACGA	0.577													T	13885086	T	T	13885086	3	4	96	1	0	0	0	0	1	0	0	0	9364	710	25	3	465	3	MC2R	18	13885086	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08		13885086	64192162	206	6598											
NPC1	4864	broad.mit.edu	37	chr18	21119357	21119357	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggtcagtgatattgtccactCgacagcaagacgactgtggc	12	10	1	2	rs120074132		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:21119357C>T	uc002kum.3	-	19	3147	c.2873G>A	c.(2872-2874)CGA>CAA	p.R958Q	NPC1_uc010xaz.1_Missense_Mutation_p.R691Q	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	958			R -> L (in NPC1).|R -> Q (in NPC1).		autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ATTGTCCACTCGACAGCAAGA	0.448													T	21119357	T	T	21119357	3	4	96	1	0	0	0	0	1	0	0	0	10570	884	31	2	991	2	NPC1	18	21119357	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	7234271	21119357	56957891	207	6599											
NPC1	4864	broad.mit.edu	37	chr18	21119839	21119839	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcattgttgcagcccatgcCgccgcacaccatgttctgcc	8	16	2	0	rs34302553	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:21119839C>T	uc002kum.3	-	18	3005	c.2731G>A	c.(2731-2733)GGC>AGC	p.G911S	NPC1_uc010xaz.1_Missense_Mutation_p.G644S|NPC1_uc010xba.1_Missense_Mutation_p.G756S	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	911					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CAGCCCATGCCGCCGCACACC	0.547													T	21119839	T	T	21119839	3	4	96	1	0	0	0	0	1	0	0	0	10570	652	23	2	1137	2	NPC1	18	21119839	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	482	21119839	56957409	208	6600											
NPC1	4864	broad.mit.edu	37	chr18	21136387	21136387	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgagcctggctgctgggggcTgaccagaggtcaactggatt	16	10	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:21136387T>C	uc002kum.3	-	8	1420	c.1146A>G	c.(1144-1146)TCA>TCG	p.S382S	NPC1_uc010xaz.1_Silent_p.S183S|NPC1_uc010xba.1_Silent_p.S227S	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	382					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TGCTGGGGGCTGACCAGAGGT	0.567													C	21136387	C	C	21136387	2	2	96	1	0	0	0	0	0	0	0	1	10570	1567	55	4		4	NPC1	18	21136387	Silent	SNP	T	TCGA-06-5858-01A-01D-1696-08	16548	21136387	56940861	209	6601											
DSG1	1828	broad.mit.edu	37	chr18	28908192	28908192	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaccagcaagttacataccGcatctctggagtaggaattg	9	9	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:28908192G>A	uc002kwp.2	+	4	469	c.257G>A	c.(256-258)CGC>CAC	p.R86H		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	86	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GTTACATACCGCATCTCTGGA	0.373													A	28908192	A	A	28908192	3	1	96	1	0	0	0	0	1	0	0	0	4776	1087	38	1	271	1	DSG1	18	28908192	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	7771805	28908192	49169056	210	6602											
KIAA1012	22878	broad.mit.edu	37	chr18	29447379	29447379	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aattaccacttttgattcttCgccattaattaagaactctg	4	9	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:29447379C>T	uc002kxc.3	-	17	2813	c.2449G>A	c.(2449-2451)GAA>AAA	p.E817K	KIAA1012_uc002kxb.3_Missense_Mutation_p.E763K|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	817					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TTTGATTCTTCGCCATTAATT	0.259													T	29447379	T	T	29447379	3	4	96	1	0	0	0	0	1	0	0	0	8204	893	31	2	1910	2	KIAA1012	18	29447379	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	539187	29447379	48629869	211	6603											
RNF165	494470	broad.mit.edu	37	chr18	44036518	44036518	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catctctttcaccaactgtgCgtggaccagtggctcgccat	9	14	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:44036518C>T	uc002lcb.1	+	8	1011	c.960C>T	c.(958-960)TGC>TGT	p.C320C	RNF165_uc002lby.1_Silent_p.C253C|RNF165_uc010dnn.1_Silent_p.C116C	NM_152470	NP_689683	Q6ZSG1	RN165_HUMAN	ring finger protein 165	320	RING-type; atypical.						zinc ion binding				0				READ - Rectum adenocarcinoma(1;0.0873)		ACCAACTGTGCGTGGACCAGT	0.587													T	44036518	T	T	44036518	2	4	96	1	0	0	0	0	0	0	0	1	13456	776	27	1		1	RNF165	18	44036518	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	14589139	44036518	34040730	212	6604											
TCEB3C	162699	broad.mit.edu	37	chr18	44554670	44554670	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcgggttttgtccgcgggcGccgcgtgccggttgctgctg	17	12	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:44554670G>A	uc010xdb.1	-	1	1780	c.1544C>T	c.(1543-1545)GCG>GTG	p.A515V	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						GTccgcgggcgccgcgtgccg	0.373													A	44554670	A	A	44554670	3	1	96	1	0	0	0	0	1	0	0	0	15680	1087	38	1	1743	1	TCEB3C	18	44554670	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	518152	44554670	33522578	213	6605											
MAPK4	5596	broad.mit.edu	37	chr18	48252336	48252336	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gctttgctccctgcagccatCgactttctggagaagatcct	9	13	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:48252336C>T	uc002lev.2	+	5	1858	c.858C>T	c.(856-858)ATC>ATT	p.I286I	MAPK4_uc010xdm.1_Silent_p.I75I|MAPK4_uc010doz.2_Intron	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	286	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		CTGCAGCCATCGACTTTCTGG	0.542													T	48252336	T	T	48252336	2	4	96	1	0	0	0	0	0	0	0	1	9280	874	31	2		2	MAPK4	18	48252336	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	3697666	48252336	29824912	214	6606											
KCNG2	26251	broad.mit.edu	37	chr18	77624216	77624216	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagctcttcgcctgcgtgtcCgtgtccttcgtggccgtcac	11	15	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr18:77624216C>T	uc010xfl.1	+	1	549	c.549C>T	c.(547-549)TCC>TCT	p.S183S		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	183	Helical; Name=Segment S1; (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CCTGCGTGTCCGTGTCCTTCG	0.458													T	77624216	T	T	77624216	2	4	96	1	0	0	0	0	0	0	0	1	8028	639	23	2		2	KCNG2	18	77624216	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	29371880	77624216	453032	215	6607											
LPPR3	79948	broad.mit.edu	37	chr19	813085	813085	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccgccttggggcccggcgCgcccggagccttggacatgg	18	15	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:813085C>T	uc002lpx.1	-	8	1706	c.1642G>A	c.(1642-1644)GCG>ACG	p.A548T	LPPR3_uc010dru.1_Intron|LPPR3_uc002lpw.1_Missense_Mutation_p.A576T|LPPR3_uc002lpy.1_Missense_Mutation_p.A329T|hsa-mir-3187|MI0014231_5'Flank	NM_024888	NP_079164	Q6T4P5	LPPR3_HUMAN	plasticity-related protein 2	548						integral to membrane	phosphatidate phosphatase activity				0						GGGCCCGGCGCGCCCGGAGCC	0.726													T	813085	T	T	813085	3	4	96	1	0	0	0	0	1	0	0	0	8926	768	27	1	518	1	LPPR3	19	813085	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08		813085	58315898	216	6608											
MLLT1	4298	broad.mit.edu	37	chr19	6222504	6222504	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttgaaggcagccttgggCggtggcgccttctcctcctt	12	14	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:6222504C>T	uc002mek.2	-	6	902	c.738G>A	c.(736-738)CCG>CCA	p.P246P		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	246					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						CAGCCTTGGGCGGTGGCGCCT	0.567			T	MLL	AL								T	6222504	T	T	6222504	2	4	96	1	0	0	0	0	0	0	0	1	9625	755	27	1		1	MLLT1	19	6222504	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	5409419	6222504	52906479	217	6609											
MUC16	94025	broad.mit.edu	37	chr19	9008202	9008202	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagactgttccggtccaggGtgtaggggcccagctctttg	15	10	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:9008202G>A	uc002mkp.2	-	41	39554	c.39350C>T	c.(39349-39351)ACC>ATC	p.T13117I	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13119	Extracellular (Potential).|SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCGGTCCAGGGTGTAGGGGCC	0.547													A	9008202	A	A	9008202	3	1	96	1	0	0	0	0	1	0	0	0	9973	1261	44	3	4349	3	MUC16	19	9008202	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	2785698	9008202	50120781	218	6610											
DNM2	1785	broad.mit.edu	37	chr19	10886407	10886407	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaccctcatcgacctcccGggtatcaccaaggtgcctgt	9	15	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:10886407G>A	uc002mps.1	+	4	578	c.414G>A	c.(412-414)CCG>CCA	p.P138P	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.P138P|DNM2_uc002mpv.1_Silent_p.P138P|DNM2_uc002mpu.1_Silent_p.P138P|DNM2_uc010dxl.1_Silent_p.P138P	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	138	GTP (By similarity).				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TCGACCTCCCGGGTATCACCA	0.587													A	10886407	A	A	10886407	2	1	96	1	0	0	0	0	0	0	0	1	4672	1103	39	2		2	DNM2	19	10886407	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	1878205	10886407	48242576	219	6611											
CARM1	10498	broad.mit.edu	37	chr19	11018751	11018751	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacatcctgaaaacctgccGgggccacaccctggagcggt	11	15	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:11018751G>A	uc002mpz.2	+	3	509	c.383G>A	c.(382-384)CGG>CAG	p.R128Q	CARM1_uc010dxn.2_RNA	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	128					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						AAAACCTGCCGGGGCCACACC	0.617													A	11018751	A	A	11018751	3	1	96	1	0	0	0	0	1	0	0	0	2655	1116	39	2	393	2	CARM1	19	11018751	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	132344	11018751	48110232	220	6612											
MAST1	22983	broad.mit.edu	37	chr19	12975736	12975736	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttgcacaactatggcatcGtgcaccgcgacctcaagcct	8	14	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:12975736G>A	uc002mvm.2	+	13	1608	c.1480G>A	c.(1480-1482)GTG>ATG	p.V494M		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	494	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CTATGGCATCGTGCACCGCGA	0.572													A	12975736	A	A	12975736	3	1	96	1	0	0	0	0	1	0	0	0	9324	1145	40	1	1530	1	MAST1	19	12975736	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	1956985	12975736	46153247	221	6613											
TRMT1	55621	broad.mit.edu	37	chr19	13216154	13216154	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcttccggcggctccttcCgcttgttctgaagcagcctg	10	15	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:13216154C>T	uc002mwj.2	-	15	2010	c.1760G>A	c.(1759-1761)CGG>CAG	p.R587Q	LYL1_uc002mwi.2_5'Flank|TRMT1_uc010xmy.1_Missense_Mutation_p.R191Q|TRMT1_uc002mwk.2_Missense_Mutation_p.R558Q|TRMT1_uc002mwl.3_Missense_Mutation_p.R587Q|TRMT1_uc010xmz.1_3'UTR	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	587							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		CGGCTCCTTCCGCTTGTTCTG	0.622											OREG0025289	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	13216154	T	T	13216154	3	4	96	1	0	0	0	0	1	0	0	0	16558	652	23	2	227	2	TRMT1	19	13216154	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	240418	13216154	45912829	222	6614											
IL27RA	9466	broad.mit.edu	37	chr19	14150709	14150709	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctaccgaagatgtcaggaggCggcctggaccctggtgagtg	16	10	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:14150709C>T	uc002mxx.2	+	4	944	c.521C>T	c.(520-522)GCG>GTG	p.A174V		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	174	Extracellular (Potential).|Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						TGTCAGGAGGCGGCCTGGACC	0.592													T	14150709	T	T	14150709	3	4	96	1	0	0	0	0	1	0	0	0	7681	768	27	1	535	1	IL27RA	19	14150709	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	934555	14150709	44978274	223	6615											
SLC27A1	376497	broad.mit.edu	37	chr19	17612106	17612106	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagggtaaggcagggatggCggccgtcgcagacccccaca	17	12	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:17612106C>T	uc002ngu.1	+	11	1711	c.1661C>T	c.(1660-1662)GCG>GTG	p.A554V	SLC27A1_uc010xpp.1_Missense_Mutation_p.A375V|SLC27A1_uc002ngv.1_Missense_Mutation_p.A156V	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	554	Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						GCAGGGATGGCGGCCGTCGCA	0.647													T	17612106	T	T	17612106	3	4	96	1	0	0	0	0	1	0	0	0	14525	768	27	1	1703	1	SLC27A1	19	17612106	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	3461397	17612106	41516877	224	6616											
NCAN	1463	broad.mit.edu	37	chr19	19356151	19356151	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactggcgagagaaccagccGgacaatttcttcgcgggtgg	14	10	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:19356151G>A	uc002nlz.2	+	13	3621	c.3522G>A	c.(3520-3522)CCG>CCA	p.P1174P	NCAN_uc002nma.2_Intron	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1174	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			AGAACCAGCCGGACAATTTCT	0.572													A	19356151	A	A	19356151	2	1	96	1	0	0	0	0	0	0	0	1	10204	1103	39	2		2	NCAN	19	19356151	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	1744045	19356151	39772832	225	6617											
NPHS1	4868	broad.mit.edu	37	chr19	36340484	36340484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggtgaatgaggccttgatgGgggcctccagtgctgggcta	17	9	0	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:36340484G>A	uc002oby.2	-	6	680	c.680C>T	c.(679-681)CCC>CTC	p.P227L		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	227	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGCCTTGATGGGGGCCTCCAG	0.587													A	36340484	A	A	36340484	3	1	96	1	0	0	0	0	1	0	0	0	10582	1232	43	3	3141	3	NPHS1	19	36340484	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	16984333	36340484	22788499	226	6618											
SIPA1L3	23094	broad.mit.edu	37	chr19	38590640	38590640	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccatcctggaagatgctacGcccacagccaccaagcatgg	9	15	0	1	rs142598144		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:38590640G>A	uc002ohk.2	+	5	2213	c.1704G>A	c.(1702-1704)ACG>ACA	p.T568T		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	568					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AAGATGCTACGCCCACAGCCA	0.607													A	38590640	A	A	38590640	2	1	96	1	0	0	0	0	0	0	0	1	14331	1074	38	1		1	SIPA1L3	19	38590640	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	2250156	38590640	20538343	227	6619											
SPTBN4	57731	broad.mit.edu	37	chr19	41009787	41009787	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggcagccatgaagaaacaCgaagcgatcgaggcagacat	13	9	0	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:41009787C>T	uc002ony.2	+	12	1499	c.1413C>T	c.(1411-1413)CAC>CAT	p.H471H	SPTBN4_uc002onx.2_Silent_p.H471H|SPTBN4_uc002onz.2_Silent_p.H471H	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	471	Spectrin 3.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGAAGAAACACGAAGCGATCG	0.622													T	41009787	T	T	41009787	2	4	96	1	0	0	0	0	0	0	0	1	15120	535	19	1		1	SPTBN4	19	41009787	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	2419147	41009787	18119196	228	6620											
ARHGEF1	9138	broad.mit.edu	37	chr19	42398544	42398544	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgatggggaaccggcggtcGgacgagcctgccaagaccaa	16	11	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:42398544G>A	uc002orx.2	+	10	874	c.765G>A	c.(763-765)TCG>TCA	p.S255S	ARHGEF1_uc002orw.1_Silent_p.S255S|ARHGEF1_uc002ory.2_Silent_p.S222S|ARHGEF1_uc002orz.2_Silent_p.S93S|ARHGEF1_uc002osa.2_Silent_p.S270S|ARHGEF1_uc002osb.2_Silent_p.S237S|ARHGEF1_uc002osc.2_5'Flank|ARHGEF1_uc002osd.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	255					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		ACCGGCGGTCGGACGAGCCTG	0.622													A	42398544	A	A	42398544	2	1	96	1	0	0	0	0	0	0	0	1	893	1103	39	2		2	ARHGEF1	19	42398544	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	1388757	42398544	16730439	229	6621											
DEDD2	162989	broad.mit.edu	37	chr19	42703643	42703643	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctccatcagcaacaggcGgcgccggccagcctcatagt	10	17	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:42703643G>A	uc002osu.1	-	5	996	c.928C>T	c.(928-930)CGC>TGC	p.R310C	DEDD2_uc002osv.1_RNA|DEDD2_uc002osw.1_Missense_Mutation_p.R305C|DEDD2_uc002osx.1_3'UTR|DEDD2_uc002osy.1_Missense_Mutation_p.R310C	NM_133328	NP_579874	Q8WXF8	DEDD2_HUMAN	death effector domain-containing  DNA binding	310					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity				0		Prostate(69;0.0704)				AGCAACAGGCGGCGCCGGCCA	0.672													A	42703643	A	A	42703643	3	1	96	1	0	0	0	0	1	0	0	0	4385	1116	39	2	56	2	DEDD2	19	42703643	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	305099	42703643	16425340	230	6622											
PSG8	440533	broad.mit.edu	37	chr19	43259226	43259226	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggtcctgtttcatttctcGtgacactgggtagaatgagg	13	7	2	3	rs150991804		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:43259226G>A	uc002ouo.2	-	4	1000	c.902C>T	c.(901-903)ACG>ATG	p.T301M	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_Intron|PSG8_uc002oui.2_Missense_Mutation_p.T140M|PSG8_uc002ouh.2_Missense_Mutation_p.T301M|PSG8_uc010ein.2_Missense_Mutation_p.T179M|PSG8_uc002ouj.3_Missense_Mutation_p.T83M|PSG8_uc002ouk.3_Missense_Mutation_p.T140M|PSG8_uc002oul.3_Missense_Mutation_p.T301M|PSG8_uc002oum.3_Missense_Mutation_p.T208M|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.T208M	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	301	Ig-like C2-type 2.					extracellular region					0		Prostate(69;0.00899)				TTCATTTCTCGTGACACTGGG	0.478													A	43259226	A	A	43259226	3	1	96	1	0	0	0	0	1	0	0	0	12661	1145	40	1	407	1	PSG8	19	43259226	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	555583	43259226	15869757	231	6623											
EML2	24139	broad.mit.edu	37	chr19	46137650	46137650	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgctgtatagcacggctaCggaggccacaaagtacacta	10	12	0	0	rs143778766		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:46137650C>T	uc002pcn.2	-	4	294	c.259G>A	c.(259-261)GTA>ATA	p.V87I	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Intron|EML2_uc010xxl.1_Missense_Mutation_p.V234I|EML2_uc010xxm.1_Missense_Mutation_p.V288I|EML2_uc010xxn.1_RNA|EML2_uc010xxo.1_Missense_Mutation_p.V87I|EML2_uc010ekj.2_Missense_Mutation_p.V87I	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	87					sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		AGCACGGCTACGGAGGCCACA	0.607													T	46137650	T	T	46137650	3	4	96	1	0	0	0	0	1	0	0	0	5097	536	19	1	1754	1	EML2	19	46137650	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	2878424	46137650	12991333	232	6624											
SYMPK	8189	broad.mit.edu	37	chr19	46345702	46345702	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgcagcttcagattcttaCgcacactgctcacctgcgat	9	13	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:46345702C>T	uc002pdn.2	-	9	1138	c.893G>A	c.(892-894)CGT>CAT	p.R298H	SYMPK_uc002pdo.1_Missense_Mutation_p.R298H|SYMPK_uc002pdp.1_Missense_Mutation_p.R298H|SYMPK_uc002pdq.1_Missense_Mutation_p.R298H	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	298					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CAGATTCTTACGCACACTGCT	0.592													T	46345702	T	T	46345702	3	4	96	1	0	0	0	0	1	0	0	0	15436	536	19	1	3007	1	SYMPK	19	46345702	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	208052	46345702	12783281	233	6625											
SYMPK	8189	broad.mit.edu	37	chr19	46351088	46351088	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gcgtcggggtatctctgagtCagccatgcggggtgacaggg	18	9	2	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:46351088C>T	uc002pdn.2	-	7	843	c.598G>A	c.(598-600)GAC>AAC	p.D200N	SYMPK_uc002pdo.1_Missense_Mutation_p.D200N|SYMPK_uc002pdp.1_Missense_Mutation_p.D200N|SYMPK_uc002pdq.1_Missense_Mutation_p.D200N	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	200					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		ATCTCTGAGTCAGCCATGCGG	0.577													T	46351088	T	T	46351088	3	4	96	1	0	0	0	0	1	0	0	0	15436	826	29	3	3310	3	SYMPK	19	46351088	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	5386	46351088	12777895	234	6626											
GRIN2D	2906	broad.mit.edu	37	chr19	48945047	48945047	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagctggacgccttcatctaCgatgctgcagtgctcaatta	9	11	3	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:48945047C>T	uc002pjc.3	+	11	2362	c.2274C>T	c.(2272-2274)TAC>TAT	p.Y758Y	GRIN2D_uc010elx.2_Translation_Start_Site	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	758	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CCTTCATCTACGATGCTGCAG	0.622													T	48945047	T	T	48945047	2	4	96	1	0	0	0	0	0	0	0	1	6782	547	19	1		1	GRIN2D	19	48945047	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	2593959	48945047	10183936	235	6627											
TSKS	60385	broad.mit.edu	37	chr19	50243103	50243103	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcctccccccattgttcccGtggacccctcaagtggcagg	10	17	1	0	rs141726866	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:50243103G>A	uc002ppm.2	-	11	1720	c.1709C>T	c.(1708-1710)ACG>ATG	p.T570M		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	570							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CATTGTTCCCGTGGACCCCTC	0.562													A	50243103	A	A	50243103	3	1	96	1	0	0	0	0	1	0	0	0	16623	1145	40	1	73	1	TSKS	19	50243103	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	1298056	50243103	8885880	236	6628											
SIGLEC6	946	broad.mit.edu	37	chr19	52034117	52034117	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggagaagatggggggcgtcCcctgctcacagacccagggc	16	12	1	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:52034117C>T	uc002pwy.2	-	3	686	c.524G>A	c.(523-525)GGG>GAG	p.G175E	SIGLEC6_uc002pwz.2_Missense_Mutation_p.G175E|SIGLEC6_uc002pxa.2_Missense_Mutation_p.G175E|SIGLEC6_uc010ydb.1_Missense_Mutation_p.G128E|SIGLEC6_uc010ydc.1_Missense_Mutation_p.G164E|SIGLEC6_uc010eoz.1_Missense_Mutation_p.G153E|SIGLEC6_uc010epb.1_Missense_Mutation_p.G128E|SIGLEC6_uc010epa.1_Missense_Mutation_p.G164E	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	175	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GGGGGGCGTCCCCTGCTCACA	0.667													T	52034117	T	T	52034117	3	4	96	1	0	0	0	0	1	0	0	0	14312	623	22	3	894	3	SIGLEC6	19	52034117	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	1791014	52034117	7094866	237	6629											
FPR1	2357	broad.mit.edu	37	chr19	52249297	52249297	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggccctctccagactggcGggaagggcgtggatcagcct	16	12	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr19:52249297G>A	uc002pxq.2	-	2	1046	c.951C>T	c.(949-951)CCC>CCT	p.P317P		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	317	Cytoplasmic (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CCAGACTGGCGGGAAGGGCGT	0.557													A	52249297	A	A	52249297	2	1	96	1	0	0	0	0	0	0	0	1	6038	1103	39	2		2	FPR1	19	52249297	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	215180	52249297	6879686	238	6630											
PREX1	57580	broad.mit.edu	37	chr20	47249039	47249039	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcctgaagctcacctttcGtgaacagcgctgtgtgcagc	12	12	1	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr20:47249039G>A	uc002xtw.1	-	34	4429	c.4406C>T	c.(4405-4407)ACG>ATG	p.T1469M	PREX1_uc002xtv.1_Missense_Mutation_p.T766M	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1469					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CTCACCTTTCGTGAACAGCGC	0.677													A	47249039	A	A	47249039	3	1	96	1	0	0	0	0	1	0	0	0	12476	1145	40	1	601	1	PREX1	20	47249039	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		47249039	15776481	239	6631											
EEF1A2	1917	broad.mit.edu	37	chr20	62126254	62126254	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgatcttcttgatgtaggcGctgacttccttgacgatctc	9	12	3	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr20:62126254G>A	uc002yfd.1	-	3	626	c.525C>T	c.(523-525)AGC>AGT	p.S175S	EEF1A2_uc002yfe.1_Silent_p.S175S|EEF1A2_uc010gkg.1_Silent_p.S175S	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	175						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			TGATGTAGGCGCTGACTTCCT	0.602													A	62126254	A	A	62126254	2	1	96	1	0	0	0	0	0	0	0	1	4924	1078	38	1		1	EEF1A2	20	62126254	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	14877215	62126254	899266	240	6632											
ADAMTS5	11096	broad.mit.edu	37	chr21	28338467	28338467	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcccaccttgccgccgccggAgtagagttggtcgatgttct	13	13	1	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr21:28338467A>C	uc002ymg.2	-	1	973	c.244T>G	c.(244-246)TCC>GCC	p.S82A		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	82					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CCGCCGCCGGAGTAGAGTTGG	0.697													C	28338467	C	C	28338467	3	2	96	1	0	0	0	0	1	0	0	0	269	304	11	5	2580	5	ADAMTS5	21	28338467	Missense_Mutation	SNP	A	TCGA-06-5858-01A-01D-1696-08		28338467	19791428	241	6633											
HSF2BP	11077	broad.mit.edu	37	chr21	44949729	44949729	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttggacattgccaggatgcGttgcaggggcagggagctcc	16	10	0	0	rs138290442	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr21:44949729G>A	uc002zdi.2	-	9	1242	c.910C>T	c.(910-912)CGC>TGC	p.R304C	HSF2BP_uc011aey.1_Missense_Mutation_p.R229C	NM_007031	NP_008962	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding	304					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)		GCCAGGATGCGTTGCAGGGGC	0.587													A	44949729	A	A	44949729	3	1	96	1	0	0	0	0	1	0	0	0	7397	1145	40	1	98	1	HSF2BP	21	44949729	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	16611262	44949729	3180166	242	6634											
ICOSLG	23308	broad.mit.edu	37	chr21	45657075	45657075	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tccacgtcgctgcctaccatCgctctgacttccttctcctg	6	18	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr21:45657075C>T	uc002zee.2	-	3	215	c.81G>A	c.(79-81)GCG>GCA	p.A27A	ICOSLG_uc011afc.1_Intron|ICOSLG_uc002zef.2_Intron|ICOSLG_uc010gpp.1_Silent_p.A27A	NM_015259	NP_056074	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand precursor	27	Ig-like V-type.|Extracellular (Potential).				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding				0				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		TGCCTACCATCGCTCTGACTT	0.498													T	45657075	T	T	45657075	2	4	96	1	0	0	0	0	0	0	0	1	7487	871	31	2		2	ICOSLG	21	45657075	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	707346	45657075	2472820	243	6635											
PFKL	5211	broad.mit.edu	37	chr21	45732042	45732042	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctttaccaccagggaggggCgccgggcagcggcctacaac	14	15	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr21:45732042C>T	uc002zel.2	+	4	351	c.292C>T	c.(292-294)CGC>TGC	p.R98C	PFKL_uc002zek.2_Missense_Mutation_p.R145C|PFKL_uc011afd.1_Missense_Mutation_p.R145C	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	98					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		CAGGGAGGGGCGCCGGGCAGC	0.642													T	45732042	T	T	45732042	3	4	96	1	0	0	0	0	1	0	0	0	11764	768	27	1	306	1	PFKL	21	45732042	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	74967	45732042	2397853	244	6636											
MICAL3	57553	broad.mit.edu	37	chr22	18301786	18301786	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtgcacagctttcagatccGagggggcatcagctttgggc	14	10	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr22:18301786G>A	uc002zng.3	-	26	3994	c.3641C>T	c.(3640-3642)TCG>TTG	p.S1214L	MICAL3_uc011agl.1_Missense_Mutation_p.S1130L	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1214	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		TTTCAGATCCGAGGGGGCATC	0.622													A	18301786	A	A	18301786	3	1	96	1	0	0	0	0	1	0	0	0	9571	1059	37	2	2395	2	MICAL3	22	18301786	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		18301786	33002780	245	6637											
TSSK2	23617	broad.mit.edu	37	chr22	19119833	19119833	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accaagacaggcttgaggccCgaccaccggcccgaccacaa	10	17	0	2	rs150037057		TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr22:19119833C>T	uc002zow.2	+	1	1513	c.921C>T	c.(919-921)CCC>CCT	p.P307P	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	307					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					GCTTGAGGCCCGACCACCGGC	0.637													T	19119833	T	T	19119833	2	4	96	1	0	0	0	0	0	0	0	1	16666	639	23	2		2	TSSK2	22	19119833	Silent	SNP	C	TCGA-06-5858-01A-01D-1696-08	818047	19119833	32184733	246	6638											
HIRA	7290	broad.mit.edu	37	chr22	19398254	19398254	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cataccttgtcctccagttgCgaacttggtcccgtcagggt	10	13	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr22:19398254C>T	uc002zpf.1	-	2	305	c.85G>A	c.(85-87)GCA>ACA	p.A29T	HIRA_uc011agx.1_5'UTR|HIRA_uc010grn.1_Missense_Mutation_p.A29T|HIRA_uc010gro.1_5'UTR|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	29	WD 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					CCTCCAGTTGCGAACTTGGTC	0.408													T	19398254	T	T	19398254	3	4	96	1	0	0	0	0	1	0	0	0	7120	768	27	1	3064	1	HIRA	22	19398254	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	278421	19398254	31906312	247	6639											
TFIP11	24144	broad.mit.edu	37	chr22	26906086	26906086	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcgctctgcccacaccccGtaggtggcttcttccttggt	9	16	3	0	rs150326842	byFrequency	TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr22:26906086G>A	uc003acr.2	-	3	527	c.153C>T	c.(151-153)TAC>TAT	p.Y51Y	TFIP11_uc003acs.2_Silent_p.Y51Y|TFIP11_uc003act.2_Silent_p.Y51Y	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	51					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						CCCACACCCCGTAGGTGGCTT	0.567													A	26906086	A	A	26906086	2	1	96	1	0	0	0	0	0	0	0	1	15804	1140	40	1		1	TFIP11	22	26906086	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	7507832	26906086	24398480	248	6640											
MCM5	4174	broad.mit.edu	37	chr22	35802697	35802697	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctggcctcgagggctatgCcctgcccaggaagtgcaaca	12	15	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr22:35802697C>T	uc003anu.3	+	5	669	c.575C>T	c.(574-576)GCC>GTC	p.A192V	MCM5_uc010gwr.2_Missense_Mutation_p.P2S|MCM5_uc003anv.3_Missense_Mutation_p.A149V|MCM5_uc010gws.1_5'Flank	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	192					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						GAGGGCTATGCCCTGCCCAGG	0.602													T	35802697	T	T	35802697	3	4	96	1	0	0	0	0	1	0	0	0	9390	739	26	3	589	3	MCM5	22	35802697	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	8896611	35802697	15501869	249	6641											
CSF2RB	1439	broad.mit.edu	37	chr22	37328885	37328885	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgggaaacaatgaaaatgcGatacgaacacatagaccaca	8	9	0	2			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr22:37328885G>A	uc003aqa.3	+	9	1308	c.1091G>A	c.(1090-1092)CGA>CAA	p.R364Q	CSF2RB_uc003aqc.3_Missense_Mutation_p.R370Q	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	364	Extracellular (Potential).|Fibronectin type-III 2.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	ATGAAAATGCGATACGAACAC	0.552													A	37328885	A	A	37328885	3	1	96	1	0	0	0	0	1	0	0	0	3935	1058	37	2	1121	2	CSF2RB	22	37328885	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	1526188	37328885	13975681	250	6642											
FAM19A5	25817	broad.mit.edu	37	chr22	49042484	49042484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctcggaggacgatcgcccGgcagaccgcccgctgtgcgt	15	16	0	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr22:49042484G>A	uc003bim.3	+	2	305	c.188G>A	c.(187-189)CGG>CAG	p.R63Q	FAM19A5_uc003bio.3_Missense_Mutation_p.R56Q	NM_001082967	NP_001076436	Q7Z5A7	F19A5_HUMAN	family with sequence similarity 19 (chemokine	63						extracellular region|integral to membrane				large_intestine(1)	1		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)		ACGATCGCCCGGCAGACCGCC	0.692													A	49042484	A	A	49042484	3	1	96	1	0	0	0	0	1	0	0	0	5535	1116	39	2	289	2	FAM19A5	22	49042484	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	11713599	49042484	2262082	251	6643											
MOV10L1	54456	broad.mit.edu	37	chr22	50596540	50596540	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttcaacccggccgaggccGtccaggtcctgcgctactgc	13	16	1	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr22:50596540G>A	uc003bjj.2	+	23	3204	c.3121G>A	c.(3121-3123)GTC>ATC	p.V1041I	MOV10L1_uc003bjk.3_Missense_Mutation_p.V1041I|MOV10L1_uc011arp.1_Missense_Mutation_p.V1021I|MOV10L1_uc003bjl.2_Missense_Mutation_p.V168I|MOV10L1_uc003bjm.1_Missense_Mutation_p.V84I	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	1041					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GGCCGAGGCCGTCCAGGTCCT	0.567													A	50596540	A	A	50596540	3	1	96	1	0	0	0	0	1	0	0	0	9719	1145	40	1	3264	1	MOV10L1	22	50596540	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	1554056	50596540	708026	252	6644											
NCAPH2	29781	broad.mit.edu	37	chr22	50957116	50957116	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcagccaatggaagtttccGtgtgcaggagccctgtccca	12	12	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chr22:50957116G>A	uc003blr.3	+	8	807	c.685G>A	c.(685-687)GTG>ATG	p.V229M	NCAPH2_uc003blq.3_Missense_Mutation_p.V229M|NCAPH2_uc003blv.2_Missense_Mutation_p.V229M|NCAPH2_uc010hbb.2_Missense_Mutation_p.V80M|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.V229M|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	229					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		GGAAGTTTCCGTGTGCAGGAG	0.647													A	50957116	A	A	50957116	3	1	96	1	0	0	0	0	1	0	0	0	10210	1145	40	1	715	1	NCAPH2	22	50957116	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	360576	50957116	347450	253	6645											
ZBED1	9189	broad.mit.edu	37	chrX	2408513	2408513	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcttcacgcatctgctccGtgttgctcttgacgaactcg	10	13	3	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chrX:2408513G>A	uc004cqg.2	-	2	449	c.248C>T	c.(247-249)ACG>ATG	p.T83M	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.T83M	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	83						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CATCTGCTCCGTGTTGCTCTT	0.632													A	2408513	A	A	2408513	3	1	96	1	0	0	0	0	1	0	0	0	17514	1145	40	1	1840	1	ZBED1	23	2408513	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08		2408513	152862047	254	6646											
HDHD1A	8226	broad.mit.edu	37	chrX	6995419	6995419	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcttcatatcgaacgacgCggaccccgagctggtggcca	12	13	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chrX:6995419C>T	uc004crv.2	-	3	429	c.352G>A	c.(352-354)GCG>ACG	p.A118T	HDHD1A_uc011mhm.1_Missense_Mutation_p.A141T|HDHD1A_uc011mhn.1_Missense_Mutation_p.A75T|HDHD1A_uc010ndl.2_Intron|HDHD1A_uc011mho.1_Missense_Mutation_p.A118T	NM_012080	NP_036212	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain	118					nucleotide metabolic process		metal ion binding|phosphatase activity				0		Colorectal(8;0.0114)|Medulloblastoma(8;0.184)				TCGAACGACGCGGACCCCGAG	0.582													T	6995419	T	T	6995419	3	4	96	1	0	0	0	0	1	0	0	0	7022	768	27	1	463	1	HDHD1A	23	6995419	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	4586906	6995419	148275141	255	6647											
CXorf22	170063	broad.mit.edu	37	chrX	35993898	35993898	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgagctagtattgagaccaCgaggcttcttcatgaaaaca	9	8	2	3			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chrX:35993898C>T	uc004ddj.2	+	15	2640	c.2581C>T	c.(2581-2583)CGA>TGA	p.R861*	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	861										large_intestine(1)|lung(1)|ovary(1)	3						ATTGAGACCACGAGGCTTCTT	0.438													T	35993898	T	T	35993898	4	4	96	1	0	0	0	0	0	1	0	0	4102	528	19	1	2639	1	CXorf22	23	35993898	Nonsense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	28998479	35993898	119276662	256	6648											
BMP15	9210	broad.mit.edu	37	chrX	50659329	50659329	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accctttccaaatcagcttcCgccagctgggttgggatcac	9	14	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chrX:50659329C>T	uc011mnw.1	+	2	901	c.901C>T	c.(901-903)CGC>TGC	p.R301C		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	301					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					AATCAGCTTCCGCCAGCTGGG	0.498													T	50659329	T	T	50659329	3	4	96	1	0	0	0	0	1	0	0	0	1458	652	23	2	907	2	BMP15	23	50659329	Missense_Mutation	SNP	C	TCGA-06-5858-01A-01D-1696-08	14665431	50659329	104611231	257	6649											
ATRX	546	broad.mit.edu	37	chrX	76814187	76814187	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggcttagtttgtccaaagcGataaactctgaatatactct	7	8	2	1			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chrX:76814187G>A	uc004ecp.3	-	29	6689	c.6457C>T	c.(6457-6459)CGC>TGC	p.R2153C	ATRX_uc004ecq.3_Missense_Mutation_p.R2115C|ATRX_uc004eco.3_Missense_Mutation_p.R1938C	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2153	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TGTCCAAAGCGATAAACTCTG	0.333			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						A	76814187	A	A	76814187	3	1	96	1	0	0	0	0	1	0	0	0	1208	1058	37	2	1049	2	ATRX	23	76814187	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	26154858	76814187	78456373	258	6650											
PCDH19	57526	broad.mit.edu	37	chrX	99662086	99662086	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggattgatggagacataggTgaagacaggcatgtcccgca	15	7	0	4			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chrX:99662086T>C	uc010nmz.2	-	1	3186	c.1510A>G	c.(1510-1512)ACC>GCC	p.T504A	PCDH19_uc004efw.3_Missense_Mutation_p.T504A|PCDH19_uc004efx.3_Missense_Mutation_p.T504A	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	504	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GAGACATAGGTGAAGACAGGC	0.577													C	99662086	C	C	99662086	3	2	96	1	0	0	0	0	1	0	0	0	11514	1696	59	4	1960	4	PCDH19	23	99662086	Missense_Mutation	SNP	T	TCGA-06-5858-01A-01D-1696-08	22847899	99662086	55608474	259	6651											
FLNA	2316	broad.mit.edu	37	chrX	153580717	153580717	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catctcagcgggaacaaagcGgatgcagtaggtgtggttct	14	8	2	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chrX:153580717G>A	uc004fkk.2	-	41	6850	c.6601C>T	c.(6601-6603)CGC>TGC	p.R2201C	FLNA_uc004fki.2_Missense_Mutation_p.R244C|FLNA_uc011mzn.1_Missense_Mutation_p.R334C|FLNA_uc010nuu.1_Missense_Mutation_p.R2193C	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2201	Filamin 20.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGAACAAAGCGGATGCAGTAG	0.597													A	153580717	A	A	153580717	3	1	96	1	0	0	0	0	1	0	0	0	5933	1116	39	2	1374	2	FLNA	23	153580717	Missense_Mutation	SNP	G	TCGA-06-5858-01A-01D-1696-08	53918631	153580717	1689843	260	6652											
FLNA	2316	broad.mit.edu	37	chrX	153587696	153587696	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactcgaccgagcagctgccGtccttgttatccatgcagga	10	13	0	0			TCGA-06-5858-01A-01D-1696-08	TCGA-06-5858-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	951799e6-12f0-4cf6-8732-f2e044db7210	a82d9e52-3c42-4897-b2e5-52af338c2196	g.chrX:153587696G>A	uc004fkk.2	-	25	4470	c.4221C>T	c.(4219-4221)GAC>GAT	p.D1407D	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Silent_p.D1407D	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1407	Filamin 12.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGCAGCTGCCGTCCTTGTTAT	0.632													A	153587696	A	A	153587696	2	1	96	1	0	0	0	0	0	0	0	1	5933	1136	40	1		1	FLNA	23	153587696	Silent	SNP	G	TCGA-06-5858-01A-01D-1696-08	6979	153587696	1682864	261	6653											
EPHA8	2046	broad.mit.edu	37	chr1	22902985	22902985	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaaagccagttcctcaaaatCgacaccattgcggccgacga	9	13	1	0	rs142515766	byFrequency	TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr1:22902985C>T	uc001bfx.1	+	3	560	c.435C>T	c.(433-435)ATC>ATT	p.I145I	EPHA8_uc001bfw.2_Silent_p.I145I	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	145	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCCTCAAAATCGACACCATTG	0.612													T	22902985	T	T	22902985	2	4	97	1	0	0	0	0	0	0	0	1	5173	874	31	2		2	EPHA8	1	22902985	Silent	SNP	C	TCGA-06-5859-01A-01D-1696-08		22902985	226347636	1	6654											
FAM129A	116496	broad.mit.edu	37	chr1	184764446	184764446	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggcagtgagtgtgcaggcctCtcctgggagctccccctcca	13	15	1	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr1:184764446C>T	uc001gra.2	-	14	2646	c.2452G>A	c.(2452-2454)GAG>AAG	p.E818K	FAM129A_uc001grb.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	818	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						GTGCAGGCCTCTCCTGGGAGC	0.647													T	184764446	T	T	184764446	3	4	97	1	0	0	0	0	1	0	0	0	5436	922	32	3	338	3	FAM129A	1	184764446	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	161861461	184764446	64486175	2	6655											
CACNA1S	779	broad.mit.edu	37	chr1	201052298	201052298	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttccgcctcaccttgcaaaCgggtcagccagagaggctgg	13	13	2	1	rs146696298		TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr1:201052298C>T	uc001gvv.2	-	10	1612	c.1385G>A	c.(1384-1386)CGT>CAT	p.R462H		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	462	Extracellular (Potential).|II.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ACCTTGCAAACGGGTCAGCCA	0.557													T	201052298	T	T	201052298	3	4	97	1	0	0	0	0	1	0	0	0	2547	536	19	1	4376	1	CACNA1S	1	201052298	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	16287852	201052298	48198323	3	6656											
KLHL12	59349	broad.mit.edu	37	chr1	202862387	202862387	+	Frame_Shift_Del	DEL	C	-	-													cctgcaattgcatagagtctCccccgaagcactgtggcccc							TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr1:202862387delC	uc001gyo.1	-	11	1760	c.1560delG	c.(1558-1560)GGGfs	p.G520fs	KLHL12_uc001gym.1_Intron|KLHL12_uc001gyn.1_Intron|KLHL12_uc010pqc.1_Frame_Shift_Del_p.G558fs|KLHL12_uc009xah.1_Frame_Shift_Del_p.G419fs	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	520	Interaction with DVL3.|Kelch 5.				Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			CATAGAGTCTCCCCCGAAGCA	0.468													-	202862387	-	-	202862387	7	5	97	1	0	1	0	1	0	0	0	0	8368	842	30	0	154	0	KLHL12	1	202862387	Frame_Shift_Del	DEL	C	TCGA-06-5859-01A-01D-1696-08	1810089	202862387	46388234	4	6657											
CCDC85A	114800	broad.mit.edu	37	chr2	56599613	56599613	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgatgcctgcctactctcccGgtgagtgaagatgagtcagc	12	12	2	4			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr2:56599613G>A	uc002rzn.2	+	4	1954	c.1452G>A	c.(1450-1452)CCG>CCA	p.P484P		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	484										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTACTCTCCCGGTGAGTGAAG	0.517													A	56599613	A	A	56599613	2	1	97	1	0	0	0	0	0	0	0	1	2859	1130	39	2		2	CCDC85A	2	56599613	Silent	SNP	G	TCGA-06-5859-01A-01D-1696-08		56599613	186599760	5	6658											
BCL11A	53335	broad.mit.edu	37	chr2	60688423	60688423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcatgacgtcgggcagggCgcggctctcgtcgcccacgc	15	16	1	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr2:60688423C>T	uc002sae.1	-	4	1852	c.1624G>A	c.(1624-1626)GCC>ACC	p.A542T	BCL11A_uc002sab.2_Missense_Mutation_p.A542T|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.A211T|BCL11A_uc010ypj.1_Missense_Mutation_p.A508T|BCL11A_uc002sad.1_Missense_Mutation_p.A390T|BCL11A_uc002saf.1_Missense_Mutation_p.A508T	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	542					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TCGGGCAGGGCGCGGCTCTCG	0.701			T	IGH@	B-CLL								T	60688423	T	T	60688423	3	4	97	1	0	0	0	0	1	0	0	0	1363	768	27	1	993	1	BCL11A	2	60688423	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	4088810	60688423	182510950	6	6659											
SGPP2	130367	broad.mit.edu	37	chr2	223423423	223423423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtgggaattgtgttgatcCtcttggttcgtcagcttgta	12	7	2	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr2:223423423C>T	uc010zlo.1	+	5	1006	c.1006C>T	c.(1006-1008)CTC>TTC	p.L336F	SGPP2_uc010zlp.1_Missense_Mutation_p.L208F	NM_152386	NP_689599	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphotase 2	336	Helical; (Potential).				sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|skin(1)	2		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TGTGTTGATCCTCTTGGTTCG	0.478													T	223423423	T	T	223423423	3	4	97	1	0	0	0	0	1	0	0	0	14220	681	24	3	1024	3	SGPP2	2	223423423	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	162735000	223423423	19775950	7	6660											
LHFPL4	375323	broad.mit.edu	37	chr3	9594193	9594193	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tagtggaagaggccgaagtaGccaggcttgggggtgctcac	17	8	1	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr3:9594193G>T	uc003bry.2	-	2	457	c.171C>A	c.(169-171)GGC>GGA	p.G57G		NM_198560	NP_940962	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4	57						integral to membrane				ovary(2)|skin(1)	3	Medulloblastoma(99;0.227)					GGCCGAAGTAGCCAGGCTTGG	0.652													T	9594193	T	T	9594193	2	4	97	1	0	0	0	0	0	0	0	1	8767	958	34	5		5	LHFPL4	3	9594193	Silent	SNP	G	TCGA-06-5859-01A-01D-1696-08		9594193	188428237	8	6661											
NPRL2	10641	broad.mit.edu	37	chr3	50386328	50386328	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtgtagtgaggtcccactGtgagttgaagaaatcctcct	11	8	0	4			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr3:50386328G>A	uc003daj.1	-	5	965	c.562C>T	c.(562-564)CAG>TAG	p.Q188*	NPRL2_uc003dai.1_Nonsense_Mutation_p.Q68*|CYB561D2_uc003dak.2_5'Flank|CYB561D2_uc003dal.2_5'Flank|CYB561D2_uc003dam.2_5'Flank	NM_006545	NP_006536	Q8WTW4	NPRL2_HUMAN	tumor suppressor candidate 4	188					negative regulation of kinase activity		protein binding|protein kinase activity			lung(1)	1						AGGTCCCACTGTGAGTTGAAG	0.537													A	50386328	A	A	50386328	4	1	97	1	0	0	0	0	0	1	0	0	10597	1386	48	3	608	3	NPRL2	3	50386328	Nonsense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	40792135	50386328	147636102	9	6662											
NPRL2	10641	broad.mit.edu	37	chr3	50387415	50387416	+	Frame_Shift_Del	DEL	TG	-	-													gtgatgatgtacacttggacTgtgtcaaacagctctcggga							TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr3:50387415_50387416delTG	uc003daj.1	-	2	519_520	c.116_117delCA	c.(115-117)ACAfs	p.T39fs	NPRL2_uc003dai.1_5'UTR|CYB561D2_uc003dak.2_5'Flank|CYB561D2_uc003dal.2_5'Flank|CYB561D2_uc003dam.2_5'Flank	NM_006545	NP_006536	Q8WTW4	NPRL2_HUMAN	tumor suppressor candidate 4	39	Interaction with PDPK1.				negative regulation of kinase activity		protein binding|protein kinase activity			lung(1)	1						ACACTTGGACTGTGTCAAACAG	0.559													-	50387416	-	-	50387415	7	5	97	1	0	1	0	1	0	0	0	0	10597	1567	55	0	1065	0	NPRL2	3	50387415	Frame_Shift_Del	DEL	TG	TCGA-06-5859-01A-01D-1696-08	1087	50387415	147635015	10	6663											
KLHL6	89857	broad.mit.edu	37	chr3	183226008	183226008	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ataggggagtaagcagagtcGttctgatggcttgtgccgga	16	6	1	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr3:183226008G>A	uc003flr.2	-	3	806	c.748C>T	c.(748-750)CGA>TGA	p.R250*	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Nonsense_Mutation_p.R248*	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	250	BACK.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			AAGCAGAGTCGTTCTGATGGC	0.418													A	183226008	A	A	183226008	4	1	97	1	0	0	0	0	0	1	0	0	8393	1153	40	1	1137	1	KLHL6	3	183226008	Nonsense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	132838593	183226008	14796422	11	6664											
PDS5A	23244	broad.mit.edu	37	chr4	39865056	39865056	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggcactaccagcagctaatCgcaagcgagacatatcagat	9	11	1	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr4:39865056C>T	uc003guv.3	-	24	3206	c.2666G>A	c.(2665-2667)CGA>CAA	p.R889Q	PDS5A_uc010ifo.2_Missense_Mutation_p.R849Q	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	889					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						AGCAGCTAATCGCAAGCGAGA	0.348													T	39865056	T	T	39865056	3	4	97	1	0	0	0	0	1	0	0	0	11691	884	31	2	1387	2	PDS5A	4	39865056	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08		39865056	151289220	12	6665											
FRAS1	80144	broad.mit.edu	37	chr4	79350365	79350365	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctggcggtcagcccaggaGgcagcacttctgtaggtaag	16	10	2	0			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr4:79350365G>A	uc003hlb.2	+	36	5268	c.4828G>A	c.(4828-4830)GGC>AGC	p.G1610S	FRAS1_uc003hkw.2_Missense_Mutation_p.G1610S|FRAS1_uc010ijj.1_Missense_Mutation_p.G30S	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1609	CSPG 5.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CAGCCCAGGAGGCAGCACTTC	0.527													A	79350365	A	A	79350365	3	1	97	1	0	0	0	0	1	0	0	0	6042	1000	35	3	4970	3	FRAS1	4	79350365	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	39485309	79350365	111803911	13	6666											
TRIML1	339976	broad.mit.edu	37	chr4	189068102	189068102	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaagatttgaccagtctgCgactgtgctgggtactcaga	13	8	2	3	rs147254109		TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr4:189068102C>T	uc003izm.1	+	6	1098	c.983C>T	c.(982-984)GCG>GTG	p.A328V	TRIML1_uc003izn.1_Missense_Mutation_p.A52V	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	328	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GACCAGTCTGCGACTGTGCTG	0.537													T	189068102	T	T	189068102	3	4	97	1	0	0	0	0	1	0	0	0	16547	768	27	1	1005	1	TRIML1	4	189068102	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	109717737	189068102	2086174	14	6667											
DNAH5	1767	broad.mit.edu	37	chr5	13762882	13762882	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aagaaggaagccatagctttCgtccaggaacaaagaccagc	10	10	0	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr5:13762882C>T	uc003jfd.2	-	60	10272	c.10230G>A	c.(10228-10230)ACG>ACA	p.T3410T	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3410	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCATAGCTTTCGTCCAGGAAC	0.453									Kartagener_syndrome				T	13762882	T	T	13762882	2	4	97	1	0	0	0	0	0	0	0	1	4604	871	31	2		2	DNAH5	5	13762882	Silent	SNP	C	TCGA-06-5859-01A-01D-1696-08		13762882	167152378	15	6668											
OCLN	4950	broad.mit.edu	37	chr5	68805301	68805301	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatggttatggctatggctaCggaggctatacagacccaag	12	8	0	1	rs150730577	byFrequency	TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr5:68805301C>T	uc003jwu.2	+	3	820	c.384C>T	c.(382-384)TAC>TAT	p.Y128Y	OCLN_uc003jwv.3_Silent_p.Y128Y	NM_002538	NP_002529			occludin												0		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		gctatggctaCGGAGGCTATA	0.403													T	68805301	T	T	68805301	2	4	97	1	0	0	0	0	0	0	0	1	10820	547	19	1		1	OCLN	5	68805301	Silent	SNP	C	TCGA-06-5859-01A-01D-1696-08	55042419	68805301	112109959	16	6669											
ADAMTS19	171019	broad.mit.edu	37	chr5	129015540	129015540	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaatttggctggaactaccGttcattatgtaagacgaggc	10	8	2	1	rs149851287		TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr5:129015540G>A	uc003kvb.1	+	17	2572	c.2572G>A	c.(2572-2574)GTT>ATT	p.V858I	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	858	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TGGAACTACCGTTCATTATGT	0.433													A	129015540	A	A	129015540	3	1	97	1	0	0	0	0	1	0	0	0	264	1145	40	1	2638	1	ADAMTS19	5	129015540	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	60210239	129015540	51899720	17	6670											
CARD11	84433	broad.mit.edu	37	chr7	2983971	2983971	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgtcattgtagctgtcccGctcttccttcatcttgtagt	7	13	4	0			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr7:2983971G>A	uc003smv.2	-	5	963	c.559C>T	c.(559-561)CGG>TGG	p.R187W		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	187	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TAGCTGTCCCGCTCTTCCTTC	0.557			Mis		DLBCL								A	2983971	A	A	2983971	3	1	97	1	0	0	0	0	1	0	0	0	2645	1086	38	1	2989	1	CARD11	7	2983971	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08		2983971	156154692	18	6671											
HERPUD2	64224	broad.mit.edu	37	chr7	35712865	35712865	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaagcagtctgcccgaataCaccaatctctgatccttcgt	8	13	2	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr7:35712865C>T	uc003tet.2	-	2	976	c.171G>A	c.(169-171)GTG>GTA	p.V57V	HERPUD2_uc003tes.3_Silent_p.V57V	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	57	Ubiquitin-like.				response to unfolded protein	integral to membrane				ovary(3)	3						TGCCCGAATACACCAATCTCT	0.373													T	35712865	T	T	35712865	2	4	97	1	0	0	0	0	0	0	0	1	7064	465	17	3		3	HERPUD2	7	35712865	Silent	SNP	C	TCGA-06-5859-01A-01D-1696-08	32728894	35712865	123425798	19	6672											
FAM40B	57464	broad.mit.edu	37	chr7	129104580	129104580	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactcaaccatatctaccagGtgagcagctaggagcacttc	8	12	2	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr7:129104580G>A	uc011koy.1	+	16	1816	c.1776_splice	c.e16+1	p.Q592_splice	FAM40B_uc003vow.2_Splice_Site_p.Q592_splice|FAM40B_uc011koz.1_Splice_Site_p.Q84_splice	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a												0						TATCTACCAGGTGAGCAGCTA	0.468													A	129104580	A	A	129104580	5	1	97	1	0	0	0	0	0	0	1	0	5561	1275	44	3	1839	3	FAM40B	7	129104580	Splice_Site	SNP	G	TCGA-06-5859-01A-01D-1696-08	93391715	129104580	30034083	20	6673											
CREB3L2	64764	broad.mit.edu	37	chr7	137686380	137686380	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgagggcctcgccgtccccGggctctgacagctcgctcag	13	16	2	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr7:137686380G>A	uc003vtw.2	-	1	467	c.72C>T	c.(70-72)CCC>CCT	p.P24P	CREB3L2_uc003vtx.1_Silent_p.P24P|CREB3L2_uc003vty.3_Silent_p.P24P|AKR1D1_uc011kqb.1_5'Flank|AKR1D1_uc011kqc.1_5'Flank|AKR1D1_uc011kqd.1_5'Flank	NM_194071	NP_919047	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like	24	Cytoplasmic (Potential).				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160						CGCCGTCCCCGGGCTCTGACA	0.706			T	FUS	fibromyxoid sarcoma								A	137686380	A	A	137686380	2	1	97	1	0	0	0	0	0	0	0	1	3857	1103	39	2		2	CREB3L2	7	137686380	Silent	SNP	G	TCGA-06-5859-01A-01D-1696-08	8581800	137686380	21452283	21	6674											
TAS2R60	338398	broad.mit.edu	37	chr7	143140562	143140562	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agagatgaatggagaccacaTggttctaggatcttcggtga	13	6	2	4			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr7:143140562T>C	uc011ktg.1	+	1	17	c.17T>C	c.(16-18)ATG>ACG	p.M6T	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	6	Extracellular (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					GGAGACCACATGGTTCTAGGA	0.468													C	143140562	C	C	143140562	3	2	97	1	0	0	0	0	1	0	0	0	15582	1464	51	4	19	4	TAS2R60	7	143140562	Missense_Mutation	SNP	T	TCGA-06-5859-01A-01D-1696-08	5454182	143140562	15998101	22	6675											
SSPO	23145	broad.mit.edu	37	chr7	149509076	149509076	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcccggtgccatcggcacCggttctgtgccaggtccccc	12	18	1	0	rs139588484	by1000genomes	TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr7:149509076C>T	uc010lpk.2	+	69	9622	c.9622C>T	c.(9622-9624)CGG>TGG	p.R3208W		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3208	TSP type-1 11.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCATCGGCACCGGTTCTGTGC	0.687													T	149509076	T	T	149509076	3	4	97	1	0	0	0	0	1	0	0	0	15188	643	23	2	9886	2	SSPO	7	149509076	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	6368514	149509076	9629587	23	6676											
DOCK5	80005	broad.mit.edu	37	chr8	25181427	25181427	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gctgatgaacccggatggcaCcactctgcaggatgggaggc	15	11	1	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr8:25181427C>A	uc003xeg.2	+	17	1816	c.1679C>A	c.(1678-1680)ACC>AAC	p.T560N	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.T274N|DOCK5_uc003xei.2_Missense_Mutation_p.T130N|DOCK5_uc003xej.2_5'Flank	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	560	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CCGGATGGCACCACTCTGCAG	0.488													A	25181427	A	A	25181427	3	1	97	1	0	0	0	0	1	0	0	0	4690	507	18	5	1745	5	DOCK5	8	25181427	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08		25181427	121182595	24	6677											
TEX15	56154	broad.mit.edu	37	chr8	30700338	30700338	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aattgtttctgagaccatgaCgatttcaatatacatttcaa	5	7	3	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr8:30700338C>T	uc003xil.2	-	1	6196	c.6196G>A	c.(6196-6198)GTC>ATC	p.V2066I		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2066										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GAGACCATGACGATTTCAATA	0.338													T	30700338	T	T	30700338	3	4	97	1	0	0	0	0	1	0	0	0	15776	536	19	1	2189	1	TEX15	8	30700338	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	5518911	30700338	115663684	25	6678											
PCMTD1	115294	broad.mit.edu	37	chr8	52733200	52733200	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaatccccttggcctgcatcTcatcatttatgaaatttcta	5	11	3	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr8:52733200T>A	uc003xqx.3	-	6	1126	c.785A>T	c.(784-786)GAG>GTG	p.E262V	PCMTD1_uc011ldm.1_Missense_Mutation_p.E132V|PCMTD1_uc003xqw.3_Missense_Mutation_p.E262V|PCMTD1_uc011ldn.1_Missense_Mutation_p.E74V|PCMTD1_uc010lya.2_Missense_Mutation_p.E186V	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	262						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				GGCCTGCATCTCATCATTTAT	0.408													A	52733200	A	A	52733200	3	1	97	1	0	0	0	0	1	0	0	0	11586	1551	54	5	292	5	PCMTD1	8	52733200	Missense_Mutation	SNP	T	TCGA-06-5859-01A-01D-1696-08	22032862	52733200	93630822	26	6679											
TCEA1	6917	broad.mit.edu	37	chr8	54897020	54897020	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catctttaagatttgatatcCtacttcgtactctatttttg	4	8	2	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr8:54897020C>T	uc003xru.2	-	7	904	c.581G>A	c.(580-582)AGG>AAG	p.R194K	TCEA1_uc003xrv.2_Missense_Mutation_p.R173K|TCEA1_uc011ldw.1_Intron|TCEA1_uc010lyg.2_RNA	NM_006756	NP_006747	P23193	TCEA1_HUMAN	transcription elongation factor A 1 isoform 1	194	TFIIS central.				positive regulation of viral transcription|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	nucleoplasm	DNA binding|translation elongation factor activity|zinc ion binding				0		Lung NSC(129;0.109)|all_epithelial(80;0.11)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;9.1e-07)|Epithelial(17;9.44e-05)|all cancers(17;0.000699)			ATTTGATATCCTACTTCGTAC	0.333			T	PLAG1	salivary adenoma								T	54897020	T	T	54897020	3	4	97	1	0	0	0	0	1	0	0	0	15664	681	24	3	340	3	TCEA1	8	54897020	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	2163820	54897020	91467002	27	6680											
OPLAH	26873	broad.mit.edu	37	chr8	145108275	145108275	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agttggggaccttgcctggcGcccgcagggcctccgtcacc	14	16	1	0			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr8:145108275G>A	uc003zar.3	-	20	2790	c.2708C>T	c.(2707-2709)GCG>GTG	p.A903V	OPLAH_uc003zas.1_Silent_p.G177G	NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	903							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CTTGCCTGGCGCCCGCAGGGC	0.642													A	145108275	A	A	145108275	3	1	97	1	0	0	0	0	1	0	0	0	10876	1087	38	1	1192	1	OPLAH	8	145108275	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	90211255	145108275	1255747	28	6681											
TLE4	7091	broad.mit.edu	37	chr9	82333807	82333807	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccacgagacacgtgtacaCgggtgggaagggctgcgtca	15	12	1	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr9:82333807C>T	uc004ald.2	+	16	2435	c.1586C>T	c.(1585-1587)ACG>ATG	p.T529M	TLE4_uc004alc.2_Missense_Mutation_p.T504M|TLE4_uc010mpr.2_Missense_Mutation_p.T383M|TLE4_uc004ale.2_Missense_Mutation_p.T141M|TLE4_uc011lsq.1_Missense_Mutation_p.T472M|TLE4_uc010mps.2_Missense_Mutation_p.T428M|TLE4_uc004alf.2_Missense_Mutation_p.T443M	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CACGTGTACACGGGTGGGAAG	0.602													T	82333807	T	T	82333807	3	4	97	1	0	0	0	0	1	0	0	0	15938	536	19	1	1569	1	TLE4	9	82333807	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08		82333807	58879624	29	6682											
ABL1	25	broad.mit.edu	37	chr9	133750310	133750310	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	accacttggtgaaggtagctGattttggcctgagcaggttg	14	7	0	3			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr9:133750310G>T	uc004bzw.2	+	7	1144	c.1141G>T	c.(1141-1143)GAT>TAT	p.D381Y	ABL1_uc004bzv.2_Missense_Mutation_p.D400Y	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	381	Kinase activation loop.|Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GAAGGTAGCTGATTTTGGCCT	0.537			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								T	133750310	T	T	133750310	3	4	97	1	0	0	0	0	1	0	0	0	92	1290	45	5	1307	5	ABL1	9	133750310	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	51416503	133750310	7463121	30	6683											
LHX3	8022	broad.mit.edu	37	chr9	139091685	139091685	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgcaccacctgcgtgggcGggatgcccagctggcacgcg	17	15	0	0			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr9:139091685G>A	uc004cha.2	-	3	390	c.293C>T	c.(292-294)CCG>CTG	p.P98L	LHX3_uc004cgz.2_Missense_Mutation_p.P103L	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	98	LIM zinc-binding 2.				inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		CTGCGTGGGCGGGATGCCCAG	0.716													A	139091685	A	A	139091685	3	1	97	1	0	0	0	0	1	0	0	0	8772	1116	39	2	916	2	LHX3	9	139091685	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	5341375	139091685	2121746	31	6684											
PPME1	51400	broad.mit.edu	37	chr11	73914828	73914828	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggagtcagtattttgagtccAtggaagatgtagaagtagag	14	3	1	4			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr11:73914828A>T	uc001ouw.2	+	2	256	c.157A>T	c.(157-159)ATG>TTG	p.M53L	PPME1_uc009yty.2_5'Flank	NM_016147	NP_057231	Q9Y570	PPME1_HUMAN	protein phosphatase methylesterase 1	53					protein demethylation		carboxylesterase activity|protein C-terminal methylesterase activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0	Breast(11;3.29e-05)					TTTTGAGTCCATGGAAGATGT	0.373													T	73914828	T	T	73914828	3	4	97	1	0	0	0	0	1	0	0	0	12347	217	8	5	163	5	PPME1	11	73914828	Missense_Mutation	SNP	A	TCGA-06-5859-01A-01D-1696-08		73914828	61091688	32	6685											
CLECL1	160365	broad.mit.edu	37	chr12	9885637	9885637	+	Frame_Shift_Del	DEL	A	-	-													ctccagccattgcacagatcAaaaagagagagaagaccaca							TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr12:9885637delA	uc001qwj.2	-	1	224	c.224delT	c.(223-225)TTGfs	p.L75fs		NM_172004	NP_742001	Q8IZS7	CLCL1_HUMAN	type II transmembrane protein DCAL1	75	Helical; Signal-anchor for type II membrane protein; (Potential).					integral to membrane|plasma membrane	sugar binding				0						TGCACAGATCAAAAAGAGAGA	0.423													-	9885637	-	-	9885637	7	5	97	1	0	1	0	1	0	0	0	0	3523	131	5	0	287	0	CLECL1	12	9885637	Frame_Shift_Del	DEL	A	TCGA-06-5859-01A-01D-1696-08		9885637	123966258	33	6686											
C12orf40	283461	broad.mit.edu	37	chr12	40040162	40040162	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aaaccaacccatgtgaacatGaatagagacataaaaatgcc	6	9	0	3			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr12:40040162G>C	uc001rmc.2	+	4	401	c.234G>C	c.(232-234)ATG>ATC	p.M78I	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	78										ovary(6)	6						ATGTGAACATGAATAGAGACA	0.274													C	40040162	C	C	40040162	3	2	97	1	0	0	0	0	1	0	0	0	1686	1290	45	5	248	5	C12orf40	12	40040162	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	30154525	40040162	93811733	34	6687											
DHRS2	10202	broad.mit.edu	37	chr14	24108199	24108199	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaccgggtagccgtggtcacGgggtccaccagtgggtgagt	17	10	1	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr14:24108199G>A	uc001wkt.3	+	2	573	c.126G>A	c.(124-126)ACG>ACA	p.T42T	DHRS2_uc010aku.1_Silent_p.T42T|DHRS2_uc001wku.3_Silent_p.T42T|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Silent_p.T42T	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	20	NAD or NADP (By similarity).				C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		CCGTGGTCACGGGGTCCACCA	0.597													A	24108199	A	A	24108199	2	1	97	1	0	0	0	0	0	0	0	1	4490	1103	39	2		2	DHRS2	14	24108199	Silent	SNP	G	TCGA-06-5859-01A-01D-1696-08		24108199	83241341	35	6688											
C15orf42	90381	broad.mit.edu	37	chr15	90168464	90168464	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaagagcagggggcaaacCtacatctgccaggcctgtac	13	12	1	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr15:90168464C>T	uc002boe.2	+	20	4923	c.4923C>T	c.(4921-4923)ACC>ACT	p.T1641T	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1641					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GGGGGCAAACCTACATCTGCC	0.612													T	90168464	T	T	90168464	2	4	97	1	0	0	0	0	0	0	0	1	1796	668	24	3		3	C15orf42	15	90168464	Silent	SNP	C	TCGA-06-5859-01A-01D-1696-08		90168464	12362928	36	6689											
MSLN	10232	broad.mit.edu	37	chr16	816982	816982	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tccagaacatgaacgggtccGaatacttcgtgaagatccag	10	10	0	4			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr16:816982G>A	uc002cjw.1	+	14	1546	c.1495G>A	c.(1495-1497)GAA>AAA	p.E499K	MSLN_uc002cjt.1_Missense_Mutation_p.E491K|MSLN_uc002cju.1_Missense_Mutation_p.E491K|MSLN_uc010brd.1_Missense_Mutation_p.E490K|MSLN_uc002cjv.1_Missense_Mutation_p.E491K|MSLN_uc002cjx.1_Missense_Mutation_p.E491K|MSLN_uc002cjy.1_Missense_Mutation_p.E156K	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	499					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				GAACGGGTCCGAATACTTCGT	0.632													A	816982	A	A	816982	3	1	97	1	0	0	0	0	1	0	0	0	9881	1059	37	2	1545	2	MSLN	16	816982	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08		816982	89537771	37	6690											
PPL	5493	broad.mit.edu	37	chr16	4945705	4945705	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctcctgagcgtccttcaCgtcttcgtgaaactagggga	11	12	2	2	rs142355114		TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr16:4945705C>T	uc002cyd.1	-	10	1075	c.985G>A	c.(985-987)GTG>ATG	p.V329M		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	329	Potential.|Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GCGTCCTTCACGTCTTCGTGA	0.577													T	4945705	T	T	4945705	3	4	97	1	0	0	0	0	1	0	0	0	12334	536	19	1	4337	1	PPL	16	4945705	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	4128723	4945705	85409048	38	6691											
SRCAP	10847	broad.mit.edu	37	chr16	30721206	30721206	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccaagaggatgaggaagaGgatgatgaggaaacgattga	15	5	0	6			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr16:30721206G>A	uc002dze.1	+	8	1276	c.891G>A	c.(889-891)GAG>GAA	p.E297E	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.E154E|SRCAP_uc010bzz.1_5'UTR|SNORA30_uc002dzh.1_5'Flank	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	297	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			ATGAGGAAGAGGATGATGAGG	0.522													A	30721206	A	A	30721206	2	1	97	1	0	0	0	0	0	0	0	1	15134	991	35	3		3	SRCAP	16	30721206	Silent	SNP	G	TCGA-06-5859-01A-01D-1696-08	25775501	30721206	59633547	39	6692											
ZNF99	7652	broad.mit.edu	37	chr19	22941588	22941588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaattgctaaaagctttgcCgcattcttcatatttgtagg	7	8	2	0			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr19:22941588C>T	uc010xrh.1	-	5	850	c.850G>A	c.(850-852)GGC>AGC	p.G284S		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAAGCTTTGCCGCATTCTTCA	0.368													T	22941588	T	T	22941588	3	4	97	1	0	0	0	0	1	0	0	0	18201	652	23	2	2274	2	ZNF99	19	22941588	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08		22941588	36187395	40	6693											
MAP4K1	11184	broad.mit.edu	37	chr19	39104548	39104548	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcccaatgaaagagaggcGtctggccagtgtagccccaa	12	11	1	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr19:39104548G>A	uc002oix.1	-	8	613	c.505C>T	c.(505-507)CGC>TGC	p.R169C	MAP4K1_uc002oiy.1_Missense_Mutation_p.R169C|MAP4K1_uc010xug.1_Translation_Start_Site	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	169	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AAAGAGAGGCGTCTGGCCAGT	0.627													A	39104548	A	A	39104548	3	1	97	1	0	0	0	0	1	0	0	0	9259	1145	40	1	2158	1	MAP4K1	19	39104548	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	16162960	39104548	20024435	41	6694											
ACTN4	81	broad.mit.edu	37	chr19	39219650	39219650	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttgcagggtgaggccgagttCaaccgcatcatgagcctggt	14	10	2	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr19:39219650C>T	uc002oja.1	+	20	2492	c.2433C>T	c.(2431-2433)TTC>TTT	p.F811F	ACTN4_uc002ojb.1_Silent_p.F133F	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	811	EF-hand 2.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGGCCGAGTTCAACCGCATCA	0.632													T	39219650	T	T	39219650	2	4	97	1	0	0	0	0	0	0	0	1	207	825	29	3		3	ACTN4	19	39219650	Silent	SNP	C	TCGA-06-5859-01A-01D-1696-08	115102	39219650	19909333	42	6695											
NCCRP1	342897	broad.mit.edu	37	chr19	39691346	39691346	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcatggagcctggtgggctgCggcggacacgggtgaccgac	19	11	0	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr19:39691346C>T	uc002okq.1	+	6	797	c.778C>T	c.(778-780)CGG>TGG	p.R260W		NM_001001414	NP_001001414	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1	260	FBA.				protein catabolic process					ovary(1)	1						TGGTGGGCTGCGGCGGACACG	0.622													T	39691346	T	T	39691346	3	4	97	1	0	0	0	0	1	0	0	0	10213	759	27	1	800	1	NCCRP1	19	39691346	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	471696	39691346	19437637	43	6696											
FCGBP	8857	broad.mit.edu	37	chr19	40396029	40396029	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggtgtagtggggatctccCgacgcctggcaggtggtaga	18	8	1	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr19:40396029C>T	uc002omp.3	-	15	7376	c.7368G>A	c.(7366-7368)TCG>TCA	p.S2456S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2456	VWFD 6.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGGGATCTCCCGACGCCTGGC	0.682													T	40396029	T	T	40396029	2	4	97	1	0	0	0	0	0	0	0	1	5778	639	23	2		2	FCGBP	19	40396029	Silent	SNP	C	TCGA-06-5859-01A-01D-1696-08	704683	40396029	18732954	44	6697											
ZNF526	116115	broad.mit.edu	37	chr19	42730234	42730234	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcgcctttgcccgcgcccCccgcctccccatcactggtc	8	22	1	0			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr19:42730234C>T	uc002osz.1	+	3	1835	c.1679C>T	c.(1678-1680)CCC>CTC	p.P560L		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				GCCCGCGCCCCCCGCCTCCCC	0.652													T	42730234	T	T	42730234	3	4	97	1	0	0	0	0	1	0	0	0	17964	623	22	3	1681	3	ZNF526	19	42730234	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	2334205	42730234	16398749	45	6698											
NCOA6	23054	broad.mit.edu	37	chr20	33364240	33364240	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctccaccttctgtacttttaGcttgctggactcttgattgt	7	11	2	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr20:33364240G>T	uc002xav.2	-	5	2818	c.247C>A	c.(247-249)CTA>ATA	p.L83I	NCOA6_uc002xaw.2_Missense_Mutation_p.L83I|NCOA6_uc010gew.1_Missense_Mutation_p.L83I	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	83	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						TGTACTTTTAGCTTGCTGGAC	0.438													T	33364240	T	T	33364240	3	4	97	1	0	0	0	0	1	0	0	0	10233	962	34	5	5992	5	NCOA6	20	33364240	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08		33364240	29661280	46	6699											
SPO11	23626	broad.mit.edu	37	chr20	55908298	55908298	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cattgcaccaccagaaagatCaaaagtgattcaccaaaatc	5	11	2	3			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr20:55908298C>G	uc002xye.2	+	3	393	c.300C>G	c.(298-300)ATC>ATG	p.I100M	SPO11_uc002xyf.2_Missense_Mutation_p.I62M	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	100					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			CCAGAAAGATCAAAAGTGATT	0.303								Editing_and_processing_nucleases					G	55908298	G	G	55908298	3	3	97	1	0	0	0	0	1	0	0	0	15076	816	29	5	310	5	SPO11	20	55908298	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	22544058	55908298	7117222	47	6700											
OSBPL2	9885	broad.mit.edu	37	chr20	60831247	60831247	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggctgctgaaggatgaacGgagaggaagaattctttgat	14	5	1	5			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr20:60831247G>A	uc002yck.1	+	2	209	c.7G>A	c.(7-9)GGA>AGA	p.G3R	OSBPL2_uc002ycl.1_Missense_Mutation_p.G3R|OSBPL2_uc011aah.1_5'UTR	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	3					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			AAGGATGAACGGAGAGGAAGA	0.483													A	60831247	A	A	60831247	3	1	97	1	0	0	0	0	1	0	0	0	11278	1117	39	2	9	2	OSBPL2	20	60831247	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	4922949	60831247	2194273	48	6701											
PIWIL3	440822	broad.mit.edu	37	chr22	25150829	25150829	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaatccagcagcttgaaaGttctggaaatggaaagaata	9	6	1	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr22:25150829G>A	uc003abd.1	-	7	1112	c.695C>T	c.(694-696)ACT>ATT	p.T232I	PIWIL3_uc011ajx.1_Missense_Mutation_p.T123I|PIWIL3_uc011ajy.1_Missense_Mutation_p.T123I|PIWIL3_uc010gut.1_Missense_Mutation_p.T232I	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	232					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						CAGCTTGAAAGTTCTGGAAAT	0.333													A	25150829	A	A	25150829	3	1	97	1	0	0	0	0	1	0	0	0	11959	1029	36	3	2013	3	PIWIL3	22	25150829	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08		25150829	26153737	49	6702											
PKDREJ	10343	broad.mit.edu	37	chr22	46655574	46655574	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtagaactatcacatgccCccgaagatgctggtccattt	9	11	1	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chr22:46655574C>T	uc003bhh.2	-	1	3646	c.3646G>A	c.(3646-3648)GGG>AGG	p.G1216R		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1216	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATCACATGCCCCCGAAGATGC	0.448													T	46655574	T	T	46655574	3	4	97	1	0	0	0	0	1	0	0	0	11970	623	22	3	3119	3	PKDREJ	22	46655574	Missense_Mutation	SNP	C	TCGA-06-5859-01A-01D-1696-08	21504745	46655574	4648992	50	6703											
P2RY8	286530	broad.mit.edu	37	chrX	1584486	1584486	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggcggagaagaggctctcGcggcgcgtgtccagggtgtc	18	11	1	2			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chrX:1584486G>A	uc004cpz.2	-	2	1214	c.966C>T	c.(964-966)CGC>CGT	p.R322R		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	322	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGAGGCTCTCGCGGCGCGTGT	0.672			T	CRLF2	B-ALL|Downs associated ALL								A	1584486	A	A	1584486	2	1	97	1	0	0	0	0	0	0	0	1	11355	1074	38	1		1	P2RY8	23	1584486	Silent	SNP	G	TCGA-06-5859-01A-01D-1696-08		1584486	153686074	51	6704											
FAM47A	158724	broad.mit.edu	37	chrX	34149408	34149408	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	atgggactctccagtctccgGaggctccgggcggagactgg	16	12	2	1			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chrX:34149408G>T	uc004ddg.2	-	1	1021	c.988C>A	c.(988-990)CCG>ACG	p.P330T		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	330										ovary(4)|central_nervous_system(1)	5						CCAGTCTCCGGAGGCTCCGGG	0.637													T	34149408	T	T	34149408	3	4	97	1	0	0	0	0	1	0	0	0	5569	1174	41	5	1391	5	FAM47A	23	34149408	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	32564922	34149408	121121152	52	6705											
L1CAM	3897	broad.mit.edu	37	chrX	153130626	153130626	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcagcagcaggctggtgttcGactggcactccaggtgcaac	14	12	0	0			TCGA-06-5859-01A-01D-1696-08	TCGA-06-5859-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bb404507-ab63-4d82-99c6-f3297bffc46f	27396ca9-1e69-46d5-95e5-339bab1b003e	g.chrX:153130626G>A	uc004fjb.2	-	21	2897	c.2789C>T	c.(2788-2790)TCG>TTG	p.S930L	L1CAM_uc004fjc.2_Missense_Mutation_p.S930L|L1CAM_uc010nuo.2_Missense_Mutation_p.S925L	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	930	Extracellular (Potential).|Fibronectin type-III 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCTGGTGTTCGACTGGCACTC	0.701													A	153130626	A	A	153130626	3	1	97	1	0	0	0	0	1	0	0	0	8588	1059	37	2	1016	2	L1CAM	23	153130626	Missense_Mutation	SNP	G	TCGA-06-5859-01A-01D-1696-08	118981218	153130626	2139934	53	6706											
TNFRSF8	943	broad.mit.edu	37	chr1	12172031	12172031	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagcccgactactacctggaCgaggccggccgctgcacggc	14	16	0	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:12172031C>T	uc001atq.2	+	7	975	c.753C>T	c.(751-753)GAC>GAT	p.D251D	TNFRSF8_uc010obc.1_Silent_p.D140D	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	251	TNFR-Cys 5.|Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		ACTACCTGGACGAGGCCGGCC	0.602													T	12172031	T	T	12172031	2	4	98	1	0	0	0	0	0	0	0	1	16296	535	19	1		1	TNFRSF8	1	12172031	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08		12172031	237078590	1	6707											
NT5C1A	84618	broad.mit.edu	37	chr1	40131873	40131873	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcgaaacaaggctcgggaGgacacagcgatggtgactgc	15	9	0	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:40131873G>A	uc001cdq.1	-	2	171	c.171C>T	c.(169-171)TCC>TCT	p.S57S		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	57					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AGGCTCGGGAGGACACAGCGA	0.582													A	40131873	A	A	40131873	2	1	98	1	0	0	0	0	0	0	0	1	10685	987	35	3		3	NT5C1A	1	40131873	Silent	SNP	G	TCGA-06-6388-01A-12D-1845-08	27959842	40131873	209118748	2	6708											
MSH4	4438	broad.mit.edu	37	chr1	76272802	76272802	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caaattatactatcccagttTgcagacaacacaacatatgc	4	11	0	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:76272802T>C	uc001dhd.1	+	3	605	c.564T>C	c.(562-564)TTT>TTC	p.F188F		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	188					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TATCCCAGTTTGCAGACAACA	0.373								MMR					C	76272802	C	C	76272802	2	2	98	1	0	0	0	0	0	0	0	1	9872	1809	63	4		4	MSH4	1	76272802	Silent	SNP	T	TCGA-06-6388-01A-12D-1845-08	36140929	76272802	172977819	3	6709											
ELTD1	64123	broad.mit.edu	37	chr1	79392712	79392712	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttttgaggtttcaataagaaGttgtcagatgatgaaagcaa	10	3	2	5			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:79392712G>T	uc001diq.3	-	8	1098	c.942C>A	c.(940-942)AAC>AAA	p.N314K		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	314	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TCAATAAGAAGTTGTCAGATG	0.318													T	79392712	T	T	79392712	3	4	98	1	0	0	0	0	1	0	0	0	5084	1020	36	5	1162	5	ELTD1	1	79392712	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	3119910	79392712	169857909	4	6710											
CCDC76	54482	broad.mit.edu	37	chr1	100602642	100602643	+	Splice_Site	INS	-	T	T													aagagagaaaccaaaacctgINStaagtgtttgatcagtaaaa							TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:100602642_100602643insT	uc001dsv.2	+	3	280	c.261_splice	c.e3+1	p.P87_splice	CCDC76_uc010ouf.1_Splice_Site|CCDC76_uc009wea.2_Splice_Site_p.P87_splice	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76						tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		ACCAAAACCTGTAAGTGTTTGA	0.238													T	100602643	T	T	100602642	8	5	98	1	0	1	1	0	0	0	1	0	2850	1391	48	0	272	0	CCDC76	1	100602642	Splice_Site	INS	-	TCGA-06-6388-01A-12D-1845-08	21209930	100602642	148647979	5	6711											
KCND3	3752	broad.mit.edu	37	chr1	112524445	112524445	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcaggccctgggagtggcGggaaaacttgaagatcctga	15	10	0	3			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:112524445G>A	uc001ebu.1	-	2	1384	c.904C>T	c.(904-906)CGC>TGC	p.R302C	KCND3_uc001ebv.1_Missense_Mutation_p.R302C	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	302	Helical; Voltage-sensor; Name=Segment S4; (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		TGGGAGTGGCGGGAAAACTTG	0.582													A	112524445	A	A	112524445	3	1	98	1	0	0	0	0	1	0	0	0	8020	1116	39	2	1091	2	KCND3	1	112524445	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	11921803	112524445	136726176	6	6712											
FLG	2312	broad.mit.edu	37	chr1	152283656	152283656	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggcagcttcatggtgacGtgaccctgagtgcctggagc	15	10	1	4	rs144184134	byFrequency	TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:152283656G>A	uc001ezu.1	-	3	3742	c.3706C>T	c.(3706-3708)CGT>TGT	p.R1236C	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1236	Ser-rich.|Filaggrin 7.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCATGGTGACGTGACCCTGAG	0.562									Ichthyosis				A	152283656	A	A	152283656	3	1	98	1	0	0	0	0	1	0	0	0	5922	1145	40	1	8483	1	FLG	1	152283656	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	39759211	152283656	96966965	7	6713											
FLG2	388698	broad.mit.edu	37	chr1	152328935	152328935	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgagccacatacatgttgttCgaacccagaggactgactca	9	11	1	3			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:152328935C>T	uc001ezw.3	-	3	1400	c.1327G>A	c.(1327-1329)GAA>AAA	p.E443K	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	443	Filaggrin 2.|Ser-rich.						calcium ion binding|structural molecule activity	p.E443V(1)		ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACATGTTGTTCGAACCCAGAG	0.448													T	152328935	T	T	152328935	3	4	98	1	0	0	0	0	1	0	0	0	5923	893	31	2	5852	2	FLG2	1	152328935	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08	45279	152328935	96921686	8	6714											
SMCP	4184	broad.mit.edu	37	chr1	152857174	152857174	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtctgagcccaactcaccGcaaactcaggacaagggctg	11	13	3	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:152857174G>A	uc001fat.2	+	2	421	c.276G>A	c.(274-276)CCG>CCA	p.P92P		NM_030663	NP_109588	P49901	MCSP_HUMAN	sperm mitochondria-associated cysteine-rich	92					penetration of zona pellucida|sperm motility	mitochondrial membrane					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCAACTCACCGCAAACTCAGG	0.537													A	152857174	A	A	152857174	2	1	98	1	0	0	0	0	0	0	0	1	14789	1074	38	1		1	SMCP	1	152857174	Silent	SNP	G	TCGA-06-6388-01A-12D-1845-08	528239	152857174	96393447	9	6715											
USH2A	7399	broad.mit.edu	37	chr1	215799138	215799138	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atcctttacaggtgggtgtcTgtgaatgtggtgcgttcctt	13	7	1	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:215799138T>C	uc001hku.1	-	72	15981	c.15594A>G	c.(15592-15594)ACA>ACG	p.T5198T		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	5198	Cytoplasmic (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGTGGGTGTCTGTGAATGTGG	0.463										HNSCC(13;0.011)			C	215799138	C	C	215799138	2	2	98	1	0	0	0	0	0	0	0	1	17033	1567	55	4		4	USH2A	1	215799138	Silent	SNP	T	TCGA-06-6388-01A-12D-1845-08	62941964	215799138	33451483	10	6716											
RYR2	6262	broad.mit.edu	37	chr1	237806746	237806746	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cagatgccaacaatagccaaAggtaaggccaacttcaattt	7	10	1	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr1:237806746A>T	uc001hyl.1	+	48	7461	c.7341A>T	c.(7339-7341)AAA>AAT	p.K2447N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2447	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAATAGCCAAAGGTAAGGCCA	0.438													T	237806746	T	T	237806746	3	4	98	1	0	0	0	0	1	0	0	0	13769	86	3	5	7531	5	RYR2	1	237806746	Missense_Mutation	SNP	A	TCGA-06-6388-01A-12D-1845-08	22007608	237806746	11443875	11	6717											
RAD51AP2	729475	broad.mit.edu	37	chr2	17692095	17692095	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaattttcttttaagtttccGtaacacatttgtttcagata	4	6	2	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr2:17692095G>A	uc002rcl.1	-	3	3480	c.3456C>T	c.(3454-3456)TAC>TAT	p.Y1152Y	RAD51AP2_uc010exn.1_Silent_p.Y1143Y	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	1152	Interaction with RAD51.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTAAGTTTCCGTAACACATTT	0.338													A	17692095	A	A	17692095	2	1	98	1	0	0	0	0	0	0	0	1	12987	1140	40	1		1	RAD51AP2	2	17692095	Silent	SNP	G	TCGA-06-6388-01A-12D-1845-08		17692095	225507278	12	6718											
TMEM17	200728	broad.mit.edu	37	chr2	62728426	62728426	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaagtcttggaggtggaaaCgaactgccaactgattaacc	10	9	1	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr2:62728426C>T	uc002sbt.2	-	4	855	c.515G>A	c.(514-516)CGT>CAT	p.R172H	TMEM17_uc002sbu.2_3'UTR|TMEM17_uc002sbv.1_3'UTR	NM_198276	NP_938017	Q86X19	TMM17_HUMAN	transmembrane protein 17	172						integral to membrane					0	Lung NSC(7;0.0274)|all_lung(7;0.0568)		LUSC - Lung squamous cell carcinoma(7;1.31e-05)|Epithelial(17;0.169)			GAGGTGGAAACGAACTGCCAA	0.423													T	62728426	T	T	62728426	3	4	98	1	0	0	0	0	1	0	0	0	16082	536	19	1	85	1	TMEM17	2	62728426	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08	45036331	62728426	180470947	13	6719											
TGFA	7039	broad.mit.edu	37	chr2	70683568	70683568	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctggctggcagccaccaCggccaggaggtccgcatgct	13	15	1	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr2:70683568C>T	uc002sgs.3	-	4	474	c.268G>A	c.(268-270)GTG>ATG	p.V90M	TGFA_uc010fdq.2_Missense_Mutation_p.V96M|TGFA_uc010fdr.2_Missense_Mutation_p.V95M|TGFA_uc002sgt.3_Missense_Mutation_p.V89M|TGFA_uc002sgu.2_Missense_Mutation_p.V89M|TGFA_uc002sgv.2_Missense_Mutation_p.V90M|TGFA_uc002sgw.2_Missense_Mutation_p.V89M	NM_003236	NP_003227	P01135	TGFA_HUMAN	transforming growth factor, alpha isoform 1	90	Extracellular (Potential).				activation of MAPK activity|cell proliferation|positive regulation of cell division|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	cell surface|extracellular space|integral to membrane|plasma membrane	epidermal growth factor receptor binding|growth factor activity|MAP kinase kinase activity|signal transducer activity	p.V90M(1)		prostate(1)	1						GCAGCCACCACGGCCAGGAGG	0.577													T	70683568	T	T	70683568	3	4	98	1	0	0	0	0	1	0	0	0	15812	536	19	1	226	1	TGFA	2	70683568	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08	7955142	70683568	172515805	14	6720											
RGPD3	653489	broad.mit.edu	37	chr2	107040566	107040566	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tagatcctgttgttgactcaTcaaagtggaaaagatttttt	8	5	2	3			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr2:107040566T>A	uc010ywi.1	-	20	3914	c.3857A>T	c.(3856-3858)GAT>GTT	p.D1286V		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1286					intracellular transport		binding			ovary(1)	1						TGTTGACTCATCAAAGTGGAA	0.408													A	107040566	A	A	107040566	3	1	98	1	0	0	0	0	1	0	0	0	13287	1435	50	5	1435	5	RGPD3	2	107040566	Missense_Mutation	SNP	T	TCGA-06-6388-01A-12D-1845-08	36356998	107040566	136158807	15	6721											
MME	4311	broad.mit.edu	37	chr3	154832945	154832945	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actagaagtcgttttgaaagGttagtagagattgtgtctgt	12	3	1	3			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr3:154832945G>A	uc010hvr.1	+	4	569	c.358_splice	c.e4+1	p.D120_splice	MME_uc003fab.1_Splice_Site_p.D120_splice|MME_uc003fac.1_Splice_Site_p.D120_splice|MME_uc003fad.1_Splice_Site_p.D120_splice|MME_uc003fae.1_Splice_Site_p.D120_splice	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase						cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GTTTTGAAAGGTTAGTAGAGA	0.378													A	154832945	A	A	154832945	5	1	98	1	0	0	0	0	0	0	1	0	9645	1275	44	3	369	3	MME	3	154832945	Splice_Site	SNP	G	TCGA-06-6388-01A-12D-1845-08		154832945	43189485	16	6722											
PLD1	5337	broad.mit.edu	37	chr3	171330189	171330189	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ccatttcactgtcacgctttCccagcatgctgcggtcattt	7	14	3	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr3:171330189C>G	uc003fhs.2	-	25	2878	c.2762G>C	c.(2761-2763)GGA>GCA	p.G921A	PLD1_uc003fht.2_Missense_Mutation_p.G883A|PLD1_uc003fhu.3_Missense_Mutation_p.G215A	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	921	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GTCACGCTTTCCCAGCATGCT	0.423													G	171330189	G	G	171330189	3	3	98	1	0	0	0	0	1	0	0	0	12045	855	30	5	474	5	PLD1	3	171330189	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08	16497244	171330189	26692241	17	6723											
LPHN3	23284	broad.mit.edu	37	chr4	62452954	62452954	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttttggcagctttcagccGtgccccaattccaatggctg	9	14	1	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr4:62452954G>A	uc010ihh.2	+	2	238	c.65G>A	c.(64-66)CGT>CAT	p.R22H	LPHN3_uc003hcq.3_Missense_Mutation_p.R22H|LPHN3_uc010ihg.1_Missense_Mutation_p.R90H	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	22	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GCTTTCAGCCGTGCCCCAATT	0.453													A	62452954	A	A	62452954	3	1	98	1	0	0	0	0	1	0	0	0	8917	1145	40	1	71	1	LPHN3	4	62452954	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08		62452954	128701322	18	6724											
CXCL1	2919	broad.mit.edu	37	chr4	74735288	74735288	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgctggccggcgcgcagcagGtgggtaccggcgccctgggg	20	14	0	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr4:74735288G>T	uc003hhh.1	+	1	179	c.100_splice	c.e1+1	p.G34_splice		NM_001511	NP_001502	P09341	GROA_HUMAN	chemokine (C-X-C motif) ligand 1						actin cytoskeleton organization|cell proliferation|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|intracellular signal transduction|negative regulation of cell proliferation|nervous system development	extracellular space|intracellular	chemokine activity|enzyme activator activity|growth factor activity				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CGCGCAGCAGGTGGGTACCGG	0.726													T	74735288	T	T	74735288	5	4	98	1	0	0	0	0	0	0	1	0	4077	1275	44	5	103	5	CXCL1	4	74735288	Splice_Site	SNP	G	TCGA-06-6388-01A-12D-1845-08	12282334	74735288	116418988	19	6725											
EPGN	255324	broad.mit.edu	37	chr4	75174232	75174232	+	Translation_Start_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tagaaggataagagaaagaaAgttaagcaactacaggaaat	10	3	0	3			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr4:75174232A>T	uc003hic.1	+	1	29	c.-18A>T	c.(-20--16)AAAGT>AATGT		uc003hhv.1_Intron|EPGN_uc003hhw.2_Translation_Start_Site|EPGN_uc003hhx.1_RNA|EPGN_uc003hhy.1_Translation_Start_Site|EPGN_uc003hhz.1_Translation_Start_Site|EPGN_uc010iin.1_Translation_Start_Site|EPGN_uc003hia.1_Translation_Start_Site|EPGN_uc003hib.1_Translation_Start_Site			Q6UW88	EPGN_HUMAN	SubName: Full=cDNA FLJ75542;						activation of MAPK activity|angiogenesis|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	extracellular region|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity|MAP kinase kinase activity				0			Lung(101;0.196)			AGAGAAAGAAAGTTAAGCAAC	0.363													T	75174232	T	T	75174232	1	4	98	1	0	0	0	0	0	0	0	0	5164	87	3	5		5	EPGN	4	75174232	Translation_Start_Site	SNP	A	TCGA-06-6388-01A-12D-1845-08	438944	75174232	115980044	20	6726											
PDHA2	5161	broad.mit.edu	37	chr4	96761394	96761394	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccgtaactcctcaaatgaCgctacatttgaaattaagaa	5	10	1	3	rs143281239		TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr4:96761394C>T	uc003htr.3	+	1	156	c.93C>T	c.(91-93)GAC>GAT	p.D31D		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	31					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CCTCAAATGACGCTACATTTG	0.502													T	96761394	T	T	96761394	2	4	98	1	0	0	0	0	0	0	0	1	11665	535	19	1		1	PDHA2	4	96761394	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08	21587162	96761394	94392882	21	6727											
PRMT10	90826	broad.mit.edu	37	chr4	148591889	148591889	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagtttctgttacaactaggGacactctatagaatgatttt	7	7	2	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr4:148591889G>A	uc003ilc.2	-	5	891	c.749C>T	c.(748-750)TCC>TTC	p.S250F	PRMT10_uc003ild.2_Missense_Mutation_p.S137F	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	250						cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						TACAACTAGGGACACTCTATA	0.328													A	148591889	A	A	148591889	3	1	98	1	0	0	0	0	1	0	0	0	12536	1174	41	3	1820	3	PRMT10	4	148591889	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	51830495	148591889	42562387	22	6728											
PIK3R1	5295	broad.mit.edu	37	chr5	67592121	67592121	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agggaagcgagatggcacttTtcttgtccgggagagcagta	15	7	1	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr5:67592121T>C	uc003jva.2	+	15	2497	c.1937T>C	c.(1936-1938)TTT>TCT	p.F646S	PIK3R1_uc003jvb.2_Missense_Mutation_p.F646S|PIK3R1_uc003jvc.2_Missense_Mutation_p.F346S|PIK3R1_uc003jvd.2_Missense_Mutation_p.F376S|PIK3R1_uc003jve.2_Missense_Mutation_p.F325S	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	646	SH2 2.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GATGGCACTTTTCTTGTCCGG	0.453			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			C	67592121	C	C	67592121	3	2	98	1	0	0	0	0	1	0	0	0	11918	1841	64	4	2121	4	PIK3R1	5	67592121	Missense_Mutation	SNP	T	TCGA-06-6388-01A-12D-1845-08		67592121	113323139	23	6729											
LNPEP	4012	broad.mit.edu	37	chr5	96320900	96320900	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cataagggatgagcaatacaCcgctttatcaaatatgccta	7	9	1	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr5:96320900C>T	uc003kmv.1	+	3	1491	c.977C>T	c.(976-978)ACC>ATC	p.T326I	LNPEP_uc003kmw.1_Missense_Mutation_p.T312I	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	326	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		GAGCAATACACCGCTTTATCA	0.378													T	96320900	T	T	96320900	3	4	98	1	0	0	0	0	1	0	0	0	8864	507	18	3	987	3	LNPEP	5	96320900	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08	28728779	96320900	84594360	24	6730											
FAT2	2196	broad.mit.edu	37	chr5	150925630	150925630	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcataggtaacttcagagggGctcatagcagagacaaggag	13	7	3	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr5:150925630G>A	uc003lue.3	-	9	5071	c.5058C>T	c.(5056-5058)AGC>AGT	p.S1686S	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1686	Cadherin 15.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTCAGAGGGGCTCATAGCAG	0.443													A	150925630	A	A	150925630	2	1	98	1	0	0	0	0	0	0	0	1	5690	1194	42	3		3	FAT2	5	150925630	Silent	SNP	G	TCGA-06-6388-01A-12D-1845-08	54604730	150925630	29989630	25	6731											
ENPP4	22875	broad.mit.edu	37	chr6	46107513	46107513	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtagagcatgttaaaaatGtttttatcacaaaaacattt	6	4	1	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr6:46107513G>A	uc003oxy.2	+	2	452	c.193G>A	c.(193-195)GTT>ATT	p.V65I		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	65	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						TGTTAAAAATGTTTTTATCAC	0.363													A	46107513	A	A	46107513	3	1	98	1	0	0	0	0	1	0	0	0	5132	1377	48	3	195	3	ENPP4	6	46107513	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08		46107513	125007554	26	6732											
KIF25	3834	broad.mit.edu	37	chr6	168443353	168443353	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcaccgtggccatgccccGtaccggaacagcaggctcac	12	16	1	0	rs147561163		TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr6:168443353G>A	uc003qwk.1	+	8	1204	c.942G>A	c.(940-942)CCG>CCA	p.P314P	KIF25_uc003qwl.1_Intron	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	314					microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GCCATGCCCCGTACCGGAACA	0.652													A	168443353	A	A	168443353	2	1	98	1	0	0	0	0	0	0	0	1	8293	1132	40	1		1	KIF25	6	168443353	Silent	SNP	G	TCGA-06-6388-01A-12D-1845-08	122335840	168443353	2671714	27	6733											
SDK1	221935	broad.mit.edu	37	chr7	4153898	4153898	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggtgcggggccggacgcGggagtcaggtgaggggaagg	25	6	1	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr7:4153898G>A	uc003smx.2	+	25	3954	c.3815G>A	c.(3814-3816)CGG>CAG	p.R1272Q	SDK1_uc010kso.2_Missense_Mutation_p.R548Q	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1272					cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGCCGGACGCGGGAGTCAGGT	0.652													A	4153898	A	A	4153898	3	1	98	1	0	0	0	0	1	0	0	0	13968	1116	39	2	3913	2	SDK1	7	4153898	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08		4153898	154984765	28	6734											
HGF	3082	broad.mit.edu	37	chr7	81386513	81386513	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactgttcttacctgtgttcGtgtggtatcatggaactcca	9	9	2	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr7:81386513G>A	uc003uhl.2	-	4	639	c.474C>T	c.(472-474)CAC>CAT	p.H158H	HGF_uc003uhm.2_Silent_p.H158H|HGF_uc003uhn.1_Silent_p.H158H|HGF_uc003uho.1_Silent_p.H158H|HGF_uc003uhp.2_Silent_p.H158H	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	158	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						ACCTGTGTTCGTGTGGTATCA	0.393													A	81386513	A	A	81386513	2	1	98	1	0	0	0	0	0	0	0	1	7085	1136	40	1		1	HGF	7	81386513	Silent	SNP	G	TCGA-06-6388-01A-12D-1845-08	77232615	81386513	77752150	29	6735											
SAMD12	401474	broad.mit.edu	37	chr8	119452171	119452171	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcctgctgggtccatagagcCaccggtttagatagcttcac	10	12	1	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr8:119452171C>G	uc003yom.2	-	3	351	c.222G>C	c.(220-222)GTG>GTC	p.V74V	SAMD12_uc010mda.1_Silent_p.V74V|SAMD12_uc010mdb.1_RNA	NM_207506	NP_997389	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12 isoform	74										ovary(1)	1	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)			TCCATAGAGCCACCGGTTTAG	0.428													G	119452171	G	G	119452171	2	3	98	1	0	0	0	0	0	0	0	1	13817	581	21	5		5	SAMD12	8	119452171	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08		119452171	26911851	30	6736											
C10orf79	80217	broad.mit.edu	37	chr10	105928529	105928529	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gctcgacctttcacagccatCgaattccaacattcttcttt	4	14	3	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr10:105928529C>T	uc001kxw.2	-	21	2780	c.2664G>A	c.(2662-2664)TCG>TCA	p.S888S	C10orf79_uc009xxq.2_Silent_p.S196S|C10orf79_uc001kxx.3_Silent_p.S889S	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	888											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TCACAGCCATCGAATTCCAAC	0.373													T	105928529	T	T	105928529	2	4	98	1	0	0	0	0	0	0	0	1	1618	871	31	2		2	C10orf79	10	105928529	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08		105928529	29606218	31	6737											
ADRB1	153	broad.mit.edu	37	chr10	115804336	115804336	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgacggccagcatcgagaccCtgtgtgtcattgccctggac	12	13	1	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr10:115804336C>T	uc001lba.2	+	1	531	c.445C>T	c.(445-447)CTG>TTG	p.L149L		NM_000684	NP_000675	P08588	ADRB1_HUMAN	beta-1-adrenergic receptor	149	Helical; Name=3; (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	CATCGAGACCCTGTGTGTCAT	0.577													T	115804336	T	T	115804336	2	4	98	1	0	0	0	0	0	0	0	1	340	680	24	3		3	ADRB1	10	115804336	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08	9875807	115804336	19730411	32	6738											
CD6	923	broad.mit.edu	37	chr11	60780934	60780934	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatagagaacaaggaatctcGggagctaatgctcctcatcc	9	10	2	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr11:60780934G>A	uc001nqq.2	+	7	1413	c.1190G>A	c.(1189-1191)CGG>CAG	p.R397Q	CD6_uc009yni.2_Missense_Mutation_p.R296Q|CD6_uc009ynj.2_Missense_Mutation_p.R274Q|CD6_uc001nqp.2_Missense_Mutation_p.R397Q|CD6_uc001nqr.2_Missense_Mutation_p.R397Q|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.R397Q	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	397	Extracellular (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						AAGGAATCTCGGGAGCTAATG	0.443													A	60780934	A	A	60780934	3	1	98	1	0	0	0	0	1	0	0	0	3028	1116	39	2	1216	2	CD6	11	60780934	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08		60780934	74225582	33	6739											
PPP2R5B	5526	broad.mit.edu	37	chr11	64695622	64695622	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatatgtggatcaaaagtttGtcctgatggtgaagtgggga	15	3	1	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr11:64695622G>T	uc001oby.2	+	5	1168	c.583G>T	c.(583-585)GTC>TTC	p.V195F	PPP2R5B_uc001obz.2_Missense_Mutation_p.V195F	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	195					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						TCAAAAGTTTGTCCTGATGGT	0.582													T	64695622	T	T	64695622	3	4	98	1	0	0	0	0	1	0	0	0	12393	1377	48	5	597	5	PPP2R5B	11	64695622	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	3914688	64695622	70310894	34	6740											
SNX32	254122	broad.mit.edu	37	chr11	65617743	65617744	+	Splice_Site	INS	-	T	T													tgaagcaggagctggaagcgINStgagtgccccctcctttccc							TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr11:65617743_65617744insT	uc001ofr.2	+	4	501	c.374_splice	c.e4+1	p.A125_splice	SNX32_uc010rop.1_3'UTR	NM_152760	NP_689973	Q86XE0	SNX32_HUMAN	sorting nexin 6B						cell communication|protein transport		phosphatidylinositol binding				0				READ - Rectum adenocarcinoma(159;0.171)		AGCTGGAAGCGTGAGTGCCCCC	0.554													T	65617744	T	T	65617743	8	5	98	1	0	1	1	0	0	0	1	0	14902	1159	40	0	389	0	SNX32	11	65617743	Splice_Site	INS	-	TCGA-06-6388-01A-12D-1845-08	922121	65617743	69388773	35	6741											
CABP4	57010	broad.mit.edu	37	chr11	67222962	67222962	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccgtcagaagccccctgCgggggttgtgactcccaaga	14	13	1	3			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr11:67222962C>T	uc001olo.2	+	1	145	c.68C>T	c.(67-69)GCG>GTG	p.A23V	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_Intron	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	23					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AAGCCCCCTGCGGGGGTTGTG	0.632													T	67222962	T	T	67222962	3	4	98	1	0	0	0	0	1	0	0	0	2533	768	27	1	70	1	CABP4	11	67222962	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08	1605219	67222962	67783554	36	6742											
AMOTL1	154810	broad.mit.edu	37	chr11	94554698	94554698	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttccattgccttgcagccGcccatgccaacttccgttcc	6	19	0	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr11:94554698G>A	uc001pfb.2	+	4	1294	c.1124G>A	c.(1123-1125)CGC>CAC	p.R375H	AMOTL1_uc001pfc.2_Missense_Mutation_p.R325H	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	375						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CCTTGCAGCCGCCCATGCCAA	0.602													A	94554698	A	A	94554698	3	1	98	1	0	0	0	0	1	0	0	0	583	1087	38	1	1138	1	AMOTL1	11	94554698	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	27331736	94554698	40451818	37	6743											
IL26	55801	broad.mit.edu	37	chr12	68619233	68619233	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttctgacttaccataaactgCttttttgttttcttttttaa	3	7	2	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr12:68619233C>G	uc001stx.1	-	2	254	c.219G>C	c.(217-219)AAG>AAC	p.K73N		NM_018402	NP_060872	Q9NPH9	IL26_HUMAN	interleukin 26 precursor	73					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		CCATAAACTGCTTTTTTGTTT	0.274													G	68619233	G	G	68619233	3	3	98	1	0	0	0	0	1	0	0	0	7679	796	28	5	312	5	IL26	12	68619233	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08		68619233	65232662	38	6744											
RCBTB1	55213	broad.mit.edu	37	chr13	50140816	50140816	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcttttaatcttctttccaCataagccttctagctttttg	5	10	3	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr13:50140816C>T	uc001vde.1	-	4	476	c.215G>A	c.(214-216)TGT>TAT	p.C72Y		NM_018191	NP_060661	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and	72	RCC1 1.				cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		CTTCTTTCCACATAAGCCTTC	0.408													T	50140816	T	T	50140816	3	4	98	1	0	0	0	0	1	0	0	0	13171	478	17	3	1420	3	RCBTB1	13	50140816	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08		50140816	65029062	39	6745											
ABCC4	10257	broad.mit.edu	37	chr13	95715080	95715080	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagggctgagatgagggaacTttttccagctccggttcttc	12	9	1	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr13:95715080T>C	uc001vmd.3	-	26	3363	c.3244A>G	c.(3244-3246)AGT>GGT	p.S1082G	ABCC4_uc010afj.2_5'UTR|ABCC4_uc010afk.2_Missense_Mutation_p.S1035G	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	1082	ABC transporter 2.|ATP 2 (Potential).				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	ATGAGGGAACTTTTTCCAGCT	0.398													C	95715080	C	C	95715080	3	2	98	1	0	0	0	0	1	0	0	0	55	1609	56	4	757	4	ABCC4	13	95715080	Missense_Mutation	SNP	T	TCGA-06-6388-01A-12D-1845-08	45574264	95715080	19454798	40	6746											
RYR3	6263	broad.mit.edu	37	chr15	33873724	33873724	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcagggaatgttggcccttGtcttaaattgcattgaccgc	10	10	2	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr15:33873724G>T	uc001zhi.2	+	14	1523	c.1453G>T	c.(1453-1455)GTC>TTC	p.V485F	RYR3_uc010bar.2_Missense_Mutation_p.V485F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	485	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTTGGCCCTTGTCTTAAATTG	0.438													T	33873724	T	T	33873724	3	4	98	1	0	0	0	0	1	0	0	0	13770	1377	48	5	1507	5	RYR3	15	33873724	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08		33873724	68657668	41	6747											
SLTM	79811	broad.mit.edu	37	chr15	59181723	59181723	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tctgagttcctctctttctcGagcaatccgttcagcttcct	6	14	4	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr15:59181723G>C	uc002afp.2	-	16	2198	c.2110C>G	c.(2110-2112)CGA>GGA	p.R704G	SLTM_uc002afn.2_Missense_Mutation_p.R246G|SLTM_uc002afo.2_Missense_Mutation_p.R686G|SLTM_uc002afq.2_Missense_Mutation_p.R273G|SLTM_uc010bgd.2_Missense_Mutation_p.R273G	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	704	Arg/Glu-rich.|Potential.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TCTCTTTCTCGAGCAATCCGT	0.413													C	59181723	C	C	59181723	3	2	98	1	0	0	0	0	1	0	0	0	14754	1066	37	5	1018	5	SLTM	15	59181723	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	25307999	59181723	43349669	42	6748											
CYP1A2	1544	broad.mit.edu	37	chr15	75042328	75042328	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagatccgcattggctccacGcccgtgctggtgctgagccg	13	15	0	2	rs17861153	byFrequency	TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr15:75042328G>A	uc002ayr.1	+	2	313	c.249G>A	c.(247-249)ACG>ACA	p.T83T		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	83			T -> M (in allele CYP1A2*9).		alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	TTGGCTCCACGCCCGTGCTGG	0.667													A	75042328	A	A	75042328	2	1	98	1	0	0	0	0	0	0	0	1	4150	1074	38	1		1	CYP1A2	15	75042328	Silent	SNP	G	TCGA-06-6388-01A-12D-1845-08	15860605	75042328	27489064	43	6749											
IL4R	3566	broad.mit.edu	37	chr16	27374339	27374339	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgggagcagatcctccgcCgaaatgtcctccagcatggg	12	14	0	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr16:27374339C>T	uc002don.2	+	11	1908	c.1666C>T	c.(1666-1668)CGA>TGA	p.R556*	IL4R_uc002dop.3_Nonsense_Mutation_p.R541*|IL4R_uc010bxy.2_Nonsense_Mutation_p.R556*|IL4R_uc002doo.2_Nonsense_Mutation_p.R396*	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	556	Cytoplasmic (Potential).|Required for IRS1 activation and IL4- induced cell growth.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						GATCCTCCGCCGAAATGTCCT	0.637													T	27374339	T	T	27374339	4	4	98	1	0	0	0	0	0	1	0	0	7698	644	23	2	1718	2	IL4R	16	27374339	Nonsense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08		27374339	62980414	44	6750											
IRX6	79190	broad.mit.edu	37	chr16	55361572	55361572	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccaccagtacactcaaggCctggctcaacgagcaccgca	9	16	2	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr16:55361572C>T	uc002ehy.2	+	4	1021	c.488C>T	c.(487-489)GCC>GTC	p.A163V	IRX6_uc002ehx.2_Missense_Mutation_p.A163V|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	163	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						ACACTCAAGGCCTGGCTCAAC	0.592													T	55361572	T	T	55361572	3	4	98	1	0	0	0	0	1	0	0	0	7848	739	26	3	502	3	IRX6	16	55361572	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08	27987233	55361572	34993181	45	6751											
SOX9	6662	broad.mit.edu	37	chr17	70118954	70118954	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccggattacaagtaccagCcgcggcggaggaagtcggtg	15	11	0	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr17:70118954C>T	uc002jiw.2	+	2	898	c.526C>T	c.(526-528)CCG>TCG	p.P176S	uc002jiv.2_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	176					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CAAGTACCAGCCGCGGCGGAG	0.652													T	70118954	T	T	70118954	3	4	98	1	0	0	0	0	1	0	0	0	14958	739	26	3	532	3	SOX9	17	70118954	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08		70118954	11076256	46	6752											
OTOP3	347741	broad.mit.edu	37	chr17	72943010	72943010	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgctggcaggtgtgtgcGtctttgtgctcttccaaatc	12	10	2	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr17:72943010G>A	uc010wrr.1	+	6	1060	c.1060G>A	c.(1060-1062)GTC>ATC	p.V354I	OTOP3_uc010wrq.1_Missense_Mutation_p.V336I	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	354	Helical; (Potential).					integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					AGGTGTGTGCGTCTTTGTGCT	0.627													A	72943010	A	A	72943010	3	1	98	1	0	0	0	0	1	0	0	0	11307	1145	40	1	1082	1	OTOP3	17	72943010	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	2824056	72943010	8252200	47	6753											
EPB41L3	23136	broad.mit.edu	37	chr18	5395093	5395093	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggtcaatgtctgcatccccCgtgatgactattcgcttctc	8	13	3	2	rs144676596		TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr18:5395093C>A	uc002kmt.1	-	21	3212	c.3126G>T	c.(3124-3126)ACG>ACT	p.T1042T	EPB41L3_uc010wzh.1_Silent_p.T873T|EPB41L3_uc002kmu.1_Silent_p.T820T|EPB41L3_uc010dkq.1_Silent_p.T711T|EPB41L3_uc002kms.1_Silent_p.T277T|EPB41L3_uc010wze.1_Silent_p.T347T|EPB41L3_uc010wzf.1_Silent_p.T339T|EPB41L3_uc010wzg.1_Silent_p.T314T|EPB41L3_uc010dkr.2_Silent_p.T434T	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1042	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CTGCATCCCCCGTGATGACTA	0.448													A	5395093	A	A	5395093	2	1	98	1	0	0	0	0	0	0	0	1	5154	639	23	5		5	EPB41L3	18	5395093	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08		5395093	72682155	48	6754											
FBXO15	201456	broad.mit.edu	37	chr18	71791770	71791770	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ctccacaaggtgatgaaaatGaagatttgccataacaaaag	8	7	0	4			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr18:71791770G>C	uc002lle.2	-	7	1057	c.721C>G	c.(721-723)CAT>GAT	p.H241D	FBXO15_uc002llf.2_Missense_Mutation_p.H317D	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	241										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		TGATGAAAATGAAGATTTGCC	0.328													C	71791770	C	C	71791770	3	2	98	1	0	0	0	0	1	0	0	0	5728	1290	45	5	599	5	FBXO15	18	71791770	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	66396677	71791770	6285478	49	6755											
FUT5	2527	broad.mit.edu	37	chr19	5867028	5867028	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcaggggcttgtgggagcGtccgtacacgtccaccttga	16	11	0	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr19:5867028G>A	uc002mdo.3	-	2	797	c.709C>T	c.(709-711)CGC>TGC	p.R237C	FUT5_uc010duo.2_Missense_Mutation_p.R237C	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	237	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						TTGTGGGAGCGTCCGTACACG	0.622													A	5867028	A	A	5867028	3	1	98	1	0	0	0	0	1	0	0	0	6107	1145	40	1	419	1	FUT5	19	5867028	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08		5867028	53261955	50	6756											
MUC16	94025	broad.mit.edu	37	chr19	9091524	9091524	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgggctggttctttgctcGgagtgtgtcattcctctaga	13	8	3	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr19:9091524G>A	uc002mkp.2	-	1	495	c.291C>T	c.(289-291)TCC>TCT	p.S97S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	97	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCTTTGCTCGGAGTGTGTCA	0.537													A	9091524	A	A	9091524	2	1	98	1	0	0	0	0	0	0	0	1	9973	1103	39	2		2	MUC16	19	9091524	Silent	SNP	G	TCGA-06-6388-01A-12D-1845-08	3224496	9091524	50037459	51	6757											
LYPD4	147719	broad.mit.edu	37	chr19	42342222	42342222	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagagataagaccggcagaCgcgactgtaggaggcaatgg	16	8	0	3	rs142442476	byFrequency	TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr19:42342222C>T	uc002orp.1	-	4	1309	c.325G>A	c.(325-327)GTC>ATC	p.V109I	LYPD4_uc002orq.1_Missense_Mutation_p.V74I	NM_173506	NP_775777	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4 precursor	109						anchored to membrane|plasma membrane				ovary(1)	1						GACCGGCAGACGCGACTGTAG	0.522													T	42342222	T	T	42342222	3	4	98	1	0	0	0	0	1	0	0	0	9112	536	19	1	423	1	LYPD4	19	42342222	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08	33250698	42342222	16786761	52	6758											
PSG2	5670	broad.mit.edu	37	chr19	43576027	43576027	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtgccggtgggttagagttCgcgaagcaagacaagtagag	16	6	0	3			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr19:43576027C>T	uc002ovr.2	-	4	882	c.789G>A	c.(787-789)GCG>GCA	p.A263A	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Silent_p.A263A|PSG2_uc010eiq.1_Silent_p.A263A|PSG2_uc002ovs.3_Silent_p.A263A|PSG2_uc002ovt.3_Silent_p.A263A	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	263	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				GGTTAGAGTTCGCGAAGCAAG	0.443													T	43576027	T	T	43576027	2	4	98	1	0	0	0	0	0	0	0	1	12655	871	31	2		2	PSG2	19	43576027	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08	1233805	43576027	15552956	53	6759											
PSG4	5672	broad.mit.edu	37	chr19	43708378	43708378	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgacttgggcagttgtgggCggattccagaagtttaaaag	15	5	0	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr19:43708378C>T	uc002ovy.2	-	2	192	c.90G>A	c.(88-90)CCG>CCA	p.P30P	PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Silent_p.P30P|PSG4_uc002ovz.2_Silent_p.P30P	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	30					defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				CAGTTGTGGGCGGATTCCAGA	0.468													T	43708378	T	T	43708378	2	4	98	1	0	0	0	0	0	0	0	1	12657	755	27	1		1	PSG4	19	43708378	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08	132351	43708378	15420605	54	6760											
NLRP4	147945	broad.mit.edu	37	chr19	56370207	56370207	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgtgagatgtgtacaggaatTgctagttgccaattttgaaa	11	4	0	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr19:56370207T>A	uc002qmd.3	+	3	1870	c.1448T>A	c.(1447-1449)TTG>TAG	p.L483*	NLRP4_uc002qmf.2_Nonsense_Mutation_p.L408*|NLRP4_uc010etf.2_Nonsense_Mutation_p.L314*	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	483							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GTACAGGAATTGCTAGTTGCC	0.423													A	56370207	A	A	56370207	4	1	98	1	0	0	0	0	0	1	0	0	10479	1821	63	5	1454	5	NLRP4	19	56370207	Nonsense_Mutation	SNP	T	TCGA-06-6388-01A-12D-1845-08	12661829	56370207	2758776	55	6761											
JAG1	182	broad.mit.edu	37	chr20	10644609	10644612	+	Splice_Site	DEL	ACGA	-	-													agtccacagaagcgatacttAcgaacggtgtcattactgga							TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr20:10644609_10644612delACGA	uc002wnw.2	-	3	955	c.439_splice	c.e3+1	p.Q147_splice		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor						angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						AGCGATACTTACGAACGGTGTCAT	0.466									Alagille_Syndrome				-	10644612	-	-	10644609	8	5	98	1	0	1	0	1	0	0	1	0	7934	405	14	0	3311	0	JAG1	20	10644609	Splice_Site	DEL	ACGA	TCGA-06-6388-01A-12D-1845-08		10644609	52380911	56	6762											
RALGAPA2	57186	broad.mit.edu	37	chr20	20493785	20493785	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctcggagccttccacatGggcattgtcatggttctcgc	11	13	2	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr20:20493785G>A	uc002wrz.2	-	32	4371	c.4228C>T	c.(4228-4230)CAT>TAT	p.H1410Y	RALGAPA2_uc010gcx.2_Missense_Mutation_p.H1114Y|RALGAPA2_uc010zsg.1_Missense_Mutation_p.H858Y|RALGAPA2_uc002wsa.1_Missense_Mutation_p.H182Y	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1410					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CCTTCCACATGGGCATTGTCA	0.547													A	20493785	A	A	20493785	3	1	98	1	0	0	0	0	1	0	0	0	13014	1348	47	3	1425	3	RALGAPA2	20	20493785	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	9849176	20493785	42531735	57	6763											
MYH7B	57644	broad.mit.edu	37	chr20	33584258	33584258	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaggccctgggtgacctgcAggccgaggaggaccgtgtga	17	11	0	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr20:33584258A>G	uc002xbi.1	+	27	3271	c.3179A>G	c.(3178-3180)CAG>CGG	p.Q1060R		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1018	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GGTGACCTGCAGGCCGAGGAG	0.672													G	33584258	G	G	33584258	3	3	98	1	0	0	0	0	1	0	0	0	10040	188	7	4	3285	4	MYH7B	20	33584258	Missense_Mutation	SNP	A	TCGA-06-6388-01A-12D-1845-08	13090473	33584258	29441262	58	6764											
NPBWR2	2832	broad.mit.edu	37	chr20	62737704	62737704	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggcgaccttcgccccccGgtaggtgcgccagggcatgt	15	15	0	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chr20:62737704G>A	uc011abt.1	-	1	481	c.481C>T	c.(481-483)CGG>TGG	p.R161W		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	161	Cytoplasmic (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					TTCGCCCCCCGGTAGGTGCGC	0.632													A	62737704	A	A	62737704	3	1	98	1	0	0	0	0	1	0	0	0	10569	1115	39	2	523	2	NPBWR2	20	62737704	Missense_Mutation	SNP	G	TCGA-06-6388-01A-12D-1845-08	29153446	62737704	287816	59	6765											
WWC3	55841	broad.mit.edu	37	chrX	10106937	10106937	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccctgggtgcttcgggaCgagcggctccgtggcctgct	15	15	0	0			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chrX:10106937C>T	uc004csx.3	+	21	3243	c.3045C>T	c.(3043-3045)GAC>GAT	p.D1015D	WWC3_uc010nds.2_Silent_p.D679D|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	1015	Potential.									ovary(4)	4						TGCTTCGGGACGAGCGGCTCC	0.711													T	10106937	T	T	10106937	2	4	98	1	0	0	0	0	0	0	0	1	17410	535	19	1		1	WWC3	23	10106937	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08		10106937	145163623	60	6766											
MAGED2	10916	broad.mit.edu	37	chrX	54841851	54841851	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgggccctgcaactgggaCgaagctgatatcggaccctg	14	13	0	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chrX:54841851C>T	uc004dtk.1	+	12	1651	c.1557C>T	c.(1555-1557)GAC>GAT	p.D519D	MAGED2_uc004dtl.1_Silent_p.D519D|MAGED2_uc004dtm.1_Silent_p.D434D|MAGED2_uc010nkc.1_Intron|MAGED2_uc004dtn.1_Silent_p.D519D|MAGED2_uc004dto.1_Silent_p.D493D	NM_177433	NP_803182	Q9UNF1	MAGD2_HUMAN	melanoma antigen family D, 2	519										ovary(2)|breast(1)	3						GCAACTGGGACGAAGCTGATA	0.488													T	54841851	T	T	54841851	2	4	98	1	0	0	0	0	0	0	0	1	9184	535	19	1		1	MAGED2	23	54841851	Silent	SNP	C	TCGA-06-6388-01A-12D-1845-08	44734914	54841851	100428709	61	6767											
NLGN3	54413	broad.mit.edu	37	chrX	70368006	70368006	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtcgctacttacatccaggAgcccaacgaagactgtctct	8	14	1	1			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chrX:70368006A>G	uc004dzd.1	+	1	607	c.407A>G	c.(406-408)GAG>GGG	p.E136G	NLGN3_uc010nlb.1_Missense_Mutation_p.E136G|NLGN3_uc004dzb.2_Missense_Mutation_p.E136G|NLGN3_uc004dzc.2_Missense_Mutation_p.E19G|NLGN3_uc011mps.1_Missense_Mutation_p.E136G|NLGN3_uc011mpr.1_Missense_Mutation_p.E136G	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	136	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					TACATCCAGGAGCCCAACGAA	0.612													G	70368006	G	G	70368006	3	3	98	1	0	0	0	0	1	0	0	0	10463	304	11	4	409	4	NLGN3	23	70368006	Missense_Mutation	SNP	A	TCGA-06-6388-01A-12D-1845-08	15526155	70368006	84902554	62	6768											
ATRX	546	broad.mit.edu	37	chrX	76937694	76937694	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atttcttctcgctcaggtaaCttttcagtgccatcagatga	7	10	5	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chrX:76937694C>A	uc004ecp.3	-	9	3286	c.3054G>T	c.(3052-3054)AAG>AAT	p.K1018N	ATRX_uc004ecq.3_Missense_Mutation_p.K980N|ATRX_uc004eco.3_Missense_Mutation_p.K803N|ATRX_uc004ecr.2_Missense_Mutation_p.K950N|ATRX_uc010nlx.1_Missense_Mutation_p.K989N|ATRX_uc010nly.1_Missense_Mutation_p.K963N	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1018					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GCTCAGGTAACTTTTCAGTGC	0.308			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						A	76937694	A	A	76937694	3	1	98	1	0	0	0	0	1	0	0	0	1208	564	20	5	4532	5	ATRX	23	76937694	Missense_Mutation	SNP	C	TCGA-06-6388-01A-12D-1845-08	6569688	76937694	78332866	63	6769											
STAG2	10735	broad.mit.edu	37	chrX	123205085	123205085	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atgttagagccattagtgtaTacccctgattcttcattgca	7	9	2	2			TCGA-06-6388-01A-12D-1845-08	TCGA-06-6388-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	c9214f8b-6684-4e29-812c-2a44963e8914	4c5eb4d1-3046-4691-99de-dd448adc1dfc	g.chrX:123205085T>A	uc004etz.3	+	24	2784	c.2445T>A	c.(2443-2445)TAT>TAA	p.Y815*	STAG2_uc004eua.2_Nonsense_Mutation_p.Y815*|STAG2_uc004eub.2_Nonsense_Mutation_p.Y815*|STAG2_uc004euc.2_Nonsense_Mutation_p.Y815*|STAG2_uc004eud.2_Nonsense_Mutation_p.Y815*|STAG2_uc004eue.2_Nonsense_Mutation_p.Y815*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	815					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CATTAGTGTATACCCCTGATT	0.363													A	123205085	A	A	123205085	4	1	98	1	0	0	0	0	0	1	0	0	15242	1413	49	5	2535	5	STAG2	23	123205085	Nonsense_Mutation	SNP	T	TCGA-06-6388-01A-12D-1845-08	46267391	123205085	32065475	64	6770											
C1orf172	126695	broad.mit.edu	37	chr1	27278819	27278819	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctctgttggccgctcccacGgtcccaagcgtggaggccca	13	16	1	0	rs145806681	byFrequency	TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr1:27278819G>A	uc001bni.1	-	2	142	c.53C>T	c.(52-54)CCG>CTG	p.P18L		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	18	Pro-rich.									large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		CCGCTCCCACGGTCCCAAGCG	0.652													A	27278819	A	A	27278819	3	1	99	1	0	0	0	0	1	0	0	0	2013	1116	39	2	1155	2	C1orf172	1	27278819	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08		27278819	221971802	1	6771											
AHDC1	27245	broad.mit.edu	37	chr1	27876436	27876436	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttcccagtcacagcgtctaCctccccccggccccgtttgc	7	21	2	0			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr1:27876436C>A	uc009vsy.2	-	6	3160	c.2191G>T	c.(2191-2193)GTA>TTA	p.V731L	AHDC1_uc009vsz.1_Missense_Mutation_p.V731L	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	731	Gly-rich.						DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		ACAGCGTCTACCTCCCCCCGG	0.662													A	27876436	A	A	27876436	3	1	99	1	0	0	0	0	1	0	0	0	412	507	18	5	2624	5	AHDC1	1	27876436	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08	597617	27876436	221374185	2	6772											
LAMC2	3918	broad.mit.edu	37	chr1	183177131	183177131	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacactgatggcattcactgCgagaagtgcaagaatggctt	11	8	1	3			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr1:183177131C>T	uc001gqa.2	+	2	509	c.195C>T	c.(193-195)TGC>TGT	p.C65C	LAMC2_uc001gpz.3_Silent_p.C65C|LAMC2_uc010poa.1_5'UTR	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	65	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						GCATTCACTGCGAGAAGTGCA	0.493													T	183177131	T	T	183177131	2	4	99	1	0	0	0	0	0	0	0	1	8615	776	27	1		1	LAMC2	1	183177131	Silent	SNP	C	TCGA-06-6389-01A-11D-1696-08	155300695	183177131	66073490	3	6773											
NEK2	4751	broad.mit.edu	37	chr1	211836944	211836944	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgttctctttactttcccCactgaaatgaactttcttct	4	11	3	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr1:211836944C>T	uc001hir.1	-	8	1308	c.1162G>A	c.(1162-1164)GGG>AGG	p.G388R	NEK2_uc001hiq.1_Missense_Mutation_p.G380R	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	388	Necessary for interaction with MAD1L1.|Interaction with PCNT.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		TTACTTTCCCCACTGAAATGA	0.403													T	211836944	T	T	211836944	3	4	99	1	0	0	0	0	1	0	0	0	10324	594	21	3	179	3	NEK2	1	211836944	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08	28659813	211836944	37413677	4	6774											
OR2W5	441932	broad.mit.edu	37	chr1	247655038	247655038	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgattcacctttgccctggGggtggctctcctcctggtgc	13	14	2	0			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr1:247655038G>A	uc001icz.1	+	1	609	c.609G>A	c.(607-609)GGG>GGA	p.G203G		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TTTGCCCTGGGGGTGGCTCTC	0.572													A	247655038	A	A	247655038	2	1	99	1	0	0	0	0	0	0	0	1	11034	1219	43	3		3	OR2W5	1	247655038	Silent	SNP	G	TCGA-06-6389-01A-11D-1696-08	35818094	247655038	1595583	5	6775											
OR2L2	26246	broad.mit.edu	37	chr1	248202130	248202130	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccagctatgttgacgctagcCtgcacagacacttgggtcta	10	12	1	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr1:248202130C>G	uc001idw.2	+	1	657	c.561C>G	c.(559-561)GCC>GCG	p.A187A	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGACGCTAGCCTGCACAGACA	0.458													G	248202130	G	G	248202130	2	3	99	1	0	0	0	0	0	0	0	1	11007	668	24	5		5	OR2L2	1	248202130	Silent	SNP	C	TCGA-06-6389-01A-11D-1696-08	547092	248202130	1048491	6	6776											
IFT172	26160	broad.mit.edu	37	chr2	27669199	27669200	+	Frame_Shift_Del	DEL	AG	-	-													gtgtgacgcaagagtgaaacAgaaagcctggcagccacggt							TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr2:27669199_27669200delAG	uc002rku.2	-	43	4733_4734	c.4682_4683delCT	c.(4681-4683)TCTfs	p.S1561fs	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1561					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					AGAGTGAAACAGAAAGCCTGGC	0.505													-	27669200	-	-	27669199	7	5	99	1	0	1	0	1	0	0	0	0	7557	175	7	0	590	0	IFT172	2	27669199	Frame_Shift_Del	DEL	AG	TCGA-06-6389-01A-11D-1696-08		27669199	215530174	7	6777											
FABP1	2168	broad.mit.edu	37	chr2	88425819	88425819	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcccattctgcacgatttccGacacccccttgatatccttc	4	17	1	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr2:88425819G>A	uc002sst.1	-	2	158	c.116C>T	c.(115-117)TCG>TTG	p.S39L	FABP1_uc002ssu.2_Missense_Mutation_p.S39L	NM_001443	NP_001434	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	39					organ morphogenesis						0						CACGATTTCCGACACCCCCTT	0.527													A	88425819	A	A	88425819	3	1	99	1	0	0	0	0	1	0	0	0	5355	1059	37	2	279	2	FABP1	2	88425819	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08	60756620	88425819	154773554	8	6778											
NCAPH	23397	broad.mit.edu	37	chr2	97007486	97007486	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcccctgcccaggaaggcGcctctcaatattcctggcac	9	16	1	0	rs139287054		TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr2:97007486G>A	uc002svz.1	+	2	210	c.126G>A	c.(124-126)GCG>GCA	p.A42A	NCAPH_uc010fhu.1_Silent_p.A18A|NCAPH_uc010fhv.1_Silent_p.A31A|NCAPH_uc010yum.1_Silent_p.A18A|NCAPH_uc010fhw.1_Silent_p.A31A|NCAPH_uc010yun.1_Intron|NCAPH_uc002swa.1_Intron	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	42					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				CCAGGAAGGCGCCTCTCAATA	0.582													A	97007486	A	A	97007486	2	1	99	1	0	0	0	0	0	0	0	1	10209	1074	38	1		1	NCAPH	2	97007486	Silent	SNP	G	TCGA-06-6389-01A-11D-1696-08	8581667	97007486	146191887	9	6779											
INHBB	3625	broad.mit.edu	37	chr2	121107075	121107075	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggtgcaggctcggctgggCgacagcaggcaccgcattcg	17	12	0	0	rs61737548	byFrequency	TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr2:121107075C>T	uc002tmn.2	+	2	895	c.849C>T	c.(847-849)GGC>GGT	p.G283G		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	283					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity	p.G283G(1)		pancreas(2)|skin(1)	3		Prostate(154;0.122)				CTCGGCTGGGCGACAGCAGGC	0.642													T	121107075	T	T	121107075	2	4	99	1	0	0	0	0	0	0	0	1	7742	755	27	1		1	INHBB	2	121107075	Silent	SNP	C	TCGA-06-6389-01A-11D-1696-08	24099589	121107075	122092298	10	6780											
KCNH7	90134	broad.mit.edu	37	chr2	163302846	163302846	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atgaccaacagcaggataagCcagtcccagactgccttgaa	9	12	0	3			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr2:163302846C>G	uc002uch.1	-	7	1448	c.1236G>C	c.(1234-1236)TGG>TGC	p.W412C	KCNH7_uc002uci.2_Missense_Mutation_p.W405C	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	412	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	GCAGGATAAGCCAGTCCCAGA	0.458													G	163302846	G	G	163302846	3	3	99	1	0	0	0	0	1	0	0	0	8037	740	26	5	2460	5	KCNH7	2	163302846	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08	42195771	163302846	79896527	11	6781											
XIRP2	129446	broad.mit.edu	37	chr2	168103799	168103799	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcagaaaacagatattcatcAggttgctgtccagaggaaca	10	8	2	3			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr2:168103799A>G	uc002udx.2	+	8	5915	c.5897A>G	c.(5896-5898)CAG>CGG	p.Q1966R	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.Q1791R|XIRP2_uc010fpq.2_Missense_Mutation_p.Q1744R|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1791					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GATATTCATCAGGTTGCTGTC	0.448													G	168103799	G	G	168103799	3	3	99	1	0	0	0	0	1	0	0	0	17427	188	7	4	5927	4	XIRP2	2	168103799	Missense_Mutation	SNP	A	TCGA-06-6389-01A-11D-1696-08	4800953	168103799	75095574	12	6782											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	99	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08	41009313	209113112	34086261	13	6783											
KIF9	64147	broad.mit.edu	37	chr3	47284680	47284680	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtcttggaggtggaaacgtAatccaagtccttcccattca	10	10	2	0			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr3:47284680A>G	uc010hjp.2	-	17	2174	c.1570T>C	c.(1570-1572)TAC>CAC	p.Y524H	KIF9_uc003cqx.2_Missense_Mutation_p.Y524H|KIF9_uc003cqy.2_Intron|KIF9_uc011bat.1_Intron|uc003cqw.1_RNA	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	524					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GTGGAAACGTAATCCAAGTCC	0.557													G	47284680	G	G	47284680	3	3	99	1	0	0	0	0	1	0	0	0	8310	362	13	4	826	4	KIF9	3	47284680	Missense_Mutation	SNP	A	TCGA-06-6389-01A-11D-1696-08		47284680	150737750	14	6784											
CACNA2D2	9254	broad.mit.edu	37	chr3	50405101	50405101	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagactcgggtgatgccacCgtctgtggcagcgaacacgg	15	11	1	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr3:50405101C>T	uc003daq.2	-	27	2328	c.2290G>A	c.(2290-2292)GGT>AGT	p.G764S	CACNA2D2_uc003dap.2_Missense_Mutation_p.G757S|CACNA2D2_uc003dao.2_5'Flank	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	764	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	GTGATGCCACCGTCTGTGGCA	0.642													T	50405101	T	T	50405101	3	4	99	1	0	0	0	0	1	0	0	0	2549	652	23	2	1220	2	CACNA2D2	3	50405101	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08	3120421	50405101	147617329	15	6785											
HPS3	84343	broad.mit.edu	37	chr3	148877986	148877986	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctgggttttcatcgatcttaGtgacattgaccaaggcagca	10	9	2	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr3:148877986G>C	uc003ewu.1	+	11	2166	c.2026G>C	c.(2026-2028)GTG>CTG	p.V676L	HPS3_uc011bnq.1_Missense_Mutation_p.V511L|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	676						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			ATCGATCTTAGTGACATTGAC	0.438									Hermansky-Pudlak_syndrome				C	148877986	C	C	148877986	3	2	99	1	0	0	0	0	1	0	0	0	7340	1029	36	5	2068	5	HPS3	3	148877986	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08	98472885	148877986	49144444	16	6786											
IL7R	3575	broad.mit.edu	37	chr5	35871249	35871249	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aatacatcacacttgcaaaaGaagtatgtaaaagttttaat	5	5	1	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr5:35871249G>C	uc003jjs.2	+	4	560	c.471G>C	c.(469-471)AAG>AAC	p.K157N	IL7R_uc011coo.1_Missense_Mutation_p.K157N|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	157	Extracellular (Potential).|Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ACTTGCAAAAGAAGTATGTAA	0.378													C	35871249	C	C	35871249	3	2	99	1	0	0	0	0	1	0	0	0	7705	933	33	5	485	5	IL7R	5	35871249	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08		35871249	145044011	17	6787											
PLCXD3	345557	broad.mit.edu	37	chr5	41382006	41382006	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tgggggtcagcaccacctgaGatataaaaaacgatcccttc	9	11	1	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr5:41382006G>T	uc003jmm.1	-	2	836	c.734C>A	c.(733-735)TCT>TAT	p.S245Y		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	245					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						CACCACCTGAGATATAAAAAA	0.483													T	41382006	T	T	41382006	3	4	99	1	0	0	0	0	1	0	0	0	12043	942	33	5	239	5	PLCXD3	5	41382006	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08	5510757	41382006	139533254	18	6788											
IL17B	27190	broad.mit.edu	37	chr5	148754111	148754111	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcacacagcccagacacaGgcaccgtgcctccggcaggt	11	16	1	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr5:148754111G>A	uc003lqo.2	-	3	414	c.364C>T	c.(364-366)CTG>TTG	p.L122L		NM_014443	NP_055258	Q9UHF5	IL17B_HUMAN	interleukin 17B precursor	122					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCAGACACAGGCACCGTGCC	0.647													A	148754111	A	A	148754111	2	1	99	1	0	0	0	0	0	0	0	1	7635	991	35	3		3	IL17B	5	148754111	Silent	SNP	G	TCGA-06-6389-01A-11D-1696-08	107372105	148754111	32161149	19	6789											
EHMT2	10919	broad.mit.edu	37	chr6	31847948	31847948	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agacggctctgctccagggcAatggcttcggctgagtgctt	14	11	1	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr6:31847948A>T	uc003nxz.1	-	28	3556	c.3546T>A	c.(3544-3546)ATT>ATA	p.I1182I	EHMT2_uc003nxv.1_Silent_p.I221I|EHMT2_uc003nxw.1_Silent_p.I221I|EHMT2_uc003nxx.1_Silent_p.I380I|EHMT2_uc003nxy.1_Silent_p.I980I|EHMT2_uc011don.1_Silent_p.I1205I|EHMT2_uc003nya.1_Silent_p.I1148I|SLC44A4_uc010jti.2_5'Flank|SLC44A4_uc011dol.1_5'Flank|SLC44A4_uc011dom.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1182					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GCTCCAGGGCAATGGCTTCGG	0.592													T	31847948	T	T	31847948	2	4	99	1	0	0	0	0	0	0	0	1	4984	126	5	5		5	EHMT2	6	31847948	Silent	SNP	A	TCGA-06-6389-01A-11D-1696-08		31847948	139267119	20	6790											
AMD1	262	broad.mit.edu	37	chr6	111214026	111214026	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcgatgaatggaatgaaatCggatgtgagtagttatatat	11	2	0	3			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr6:111214026C>T	uc003puk.1	+	7	1026	c.704C>T	c.(703-705)TCG>TTG	p.S235L	AMD1_uc011eay.1_Missense_Mutation_p.S166L|AMD1_uc011eaz.1_Missense_Mutation_p.S206L|AMD1_uc011eba.1_Missense_Mutation_p.S115L|AMD1_uc003pul.1_Missense_Mutation_p.S87L	NM_001634	NP_001625	P17707	DCAM_HUMAN	adenosylmethionine decarboxylase 1 isoform 1	235					spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			upper_aerodigestive_tract(1)	1		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)	GGAATGAAATCGGATGTGAGT	0.388													T	111214026	T	T	111214026	3	4	99	1	0	0	0	0	1	0	0	0	566	893	31	2	730	2	AMD1	6	111214026	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08	79366078	111214026	59901041	21	6791											
RNF148	378925	broad.mit.edu	37	chr7	122342705	122342705	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctgtccaaatggcttttcCgtttgagtcaggaaagctaa	10	8	1	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr7:122342705C>T	uc003vkk.1	-	1	317	c.100G>A	c.(100-102)GGA>AGA	p.G34R	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF148_uc010lkr.1_Missense_Mutation_p.G34R	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	34						integral to membrane	zinc ion binding				0						ATGGCTTTTCCGTTTGAGTCA	0.423													T	122342705	T	T	122342705	3	4	99	1	0	0	0	0	1	0	0	0	13449	661	23	2	821	2	RNF148	7	122342705	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08		122342705	36795958	22	6792											
TEX15	56154	broad.mit.edu	37	chr8	30705338	30705338	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctatgttataagatgaaataActgtatcaatgaacatttct	5	5	2	3			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr8:30705338A>T	uc003xil.2	-	1	1196	c.1196T>A	c.(1195-1197)GTT>GAT	p.V399D		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	399										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGATGAAATAACTGTATCAAT	0.333													T	30705338	T	T	30705338	3	4	99	1	0	0	0	0	1	0	0	0	15776	43	2	5	7189	5	TEX15	8	30705338	Missense_Mutation	SNP	A	TCGA-06-6389-01A-11D-1696-08		30705338	115658684	23	6793											
SYBU	55638	broad.mit.edu	37	chr8	110587269	110587269	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatgcccacagaaccgtggGgaccacgggggcagccacag	15	13	0	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr8:110587269G>A	uc003ynj.3	-	7	2021	c.1858C>T	c.(1858-1860)CCC>TCC	p.P620S	SYBU_uc003yni.3_Missense_Mutation_p.P617S|SYBU_uc003ynk.3_Missense_Mutation_p.P501S|SYBU_uc010mco.2_Missense_Mutation_p.P619S|SYBU_uc003ynl.3_Missense_Mutation_p.P619S|SYBU_uc010mcp.2_Missense_Mutation_p.P620S|SYBU_uc010mcq.2_Missense_Mutation_p.P620S|SYBU_uc003yno.3_Missense_Mutation_p.P501S|SYBU_uc010mcr.2_Missense_Mutation_p.P620S|SYBU_uc003ynm.3_Missense_Mutation_p.P619S|SYBU_uc003ynn.3_Missense_Mutation_p.P619S|SYBU_uc010mcs.2_Missense_Mutation_p.P501S|SYBU_uc010mct.2_Missense_Mutation_p.P620S|SYBU_uc010mcu.2_Missense_Mutation_p.P619S|SYBU_uc003ynp.3_Missense_Mutation_p.P552S|SYBU_uc010mcv.2_Missense_Mutation_p.P620S|SYBU_uc003ynh.3_Missense_Mutation_p.P414S|SYBU_uc011lhw.1_Missense_Mutation_p.P490S	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	620	Helical; (Potential).					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						AGAACCGTGGGGACCACGGGG	0.622													A	110587269	A	A	110587269	3	1	99	1	0	0	0	0	1	0	0	0	15424	1232	43	3	137	3	SYBU	8	110587269	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08	79881931	110587269	35776753	24	6794											
HAS2	3037	broad.mit.edu	37	chr8	122641322	122641322	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgataggcagcgatgcaaaGggcaactgttttgttcaact	11	7	1	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr8:122641322G>A	uc003yph.2	-	2	797	c.259C>T	c.(259-261)CTT>TTT	p.L87F		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	87	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GCGATGCAAAGGGCAACTGTT	0.423													A	122641322	A	A	122641322	3	1	99	1	0	0	0	0	1	0	0	0	6962	1000	35	3	1411	3	HAS2	8	122641322	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08	12054053	122641322	23722700	25	6795											
C9orf152	401546	broad.mit.edu	37	chr9	112963591	112963591	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacaatgcatctccaggtgCgtgtgccatggagacttggg	13	9	1	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr9:112963591C>T	uc011lwk.1	-	2	911	c.357G>A	c.(355-357)ACG>ACA	p.T119T		NM_001012993	NP_001013011	Q5JTZ5	CI152_HUMAN	hypothetical protein LOC401546	119											0						TCTCCAGGTGCGTGTGCCATG	0.587													T	112963591	T	T	112963591	2	4	99	1	0	0	0	0	0	0	0	1	2463	755	27	1		1	C9orf152	9	112963591	Silent	SNP	C	TCGA-06-6389-01A-11D-1696-08		112963591	28249840	26	6796											
FCN1	2219	broad.mit.edu	37	chr9	137801822	137801822	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggaacttctcagcacaattcGaagaactcacatcattgtct	6	11	4	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr9:137801822G>A	uc004cfi.2	-	9	895	c.803C>T	c.(802-804)TCG>TTG	p.S268L		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	268	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		AGCACAATTCGAAGAACTCAC	0.488													A	137801822	A	A	137801822	3	1	99	1	0	0	0	0	1	0	0	0	5791	1059	37	2	181	2	FCN1	9	137801822	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08	24838231	137801822	3411609	27	6797											
CDH23	64072	broad.mit.edu	37	chr10	73544851	73544851	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagcgggccttcttcatcaaTgccacggtagggcctagact	12	12	3	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr10:73544851T>C	uc001jrx.3	+	41	6083	c.5706T>C	c.(5704-5706)AAT>AAC	p.N1902N		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1902	Cadherin 18.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						TCTTCATCAATGCCACGGTAG	0.597													C	73544851	C	C	73544851	2	2	99	1	0	0	0	0	0	0	0	1	3108	1461	51	4		4	CDH23	10	73544851	Silent	SNP	T	TCGA-06-6389-01A-11D-1696-08		73544851	61989896	28	6798											
RGR	5995	broad.mit.edu	37	chr10	86017694	86017694	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctgctgctcggctggggcCcctatgccatcctgtatcta	11	15	1	0			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr10:86017694C>T	uc001kdc.1	+	6	714	c.676C>T	c.(676-678)CCC>TCC	p.P226S	RGR_uc001kdd.1_Missense_Mutation_p.P230S|RGR_uc001kde.1_Intron	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	226	Helical; Name=6; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						CGGCTGGGGCCCCTATGCCAT	0.542													T	86017694	T	T	86017694	3	4	99	1	0	0	0	0	1	0	0	0	13291	623	22	3	710	3	RGR	10	86017694	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08	12472843	86017694	49517053	29	6799											
ABCC9	10060	broad.mit.edu	37	chr12	21968799	21968799	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcttgatctccccttcttgTggccaatgttctggaacttg	8	11	4	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr12:21968799T>G	uc001rfi.1	-	32	3941	c.3921A>C	c.(3919-3921)CCA>CCC	p.P1307P	ABCC9_uc001rfh.2_Silent_p.P1307P|ABCC9_uc001rfj.1_Silent_p.P1271P	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1307	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCCCTTCTTGTGGCCAATGTT	0.383													G	21968799	G	G	21968799	2	3	99	1	0	0	0	0	0	0	0	1	59	1683	59	5		5	ABCC9	12	21968799	Silent	SNP	T	TCGA-06-6389-01A-11D-1696-08		21968799	111883096	30	6800											
CYP1A2	1544	broad.mit.edu	37	chr15	75042134	75042134	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagcttctcctggcctctGccatcttctgcctggtattc	8	15	4	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr15:75042134G>A	uc002ayr.1	+	2	119	c.55G>A	c.(55-57)GCC>ACC	p.A19T		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	19					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CCTGGCCTCTGCCATCTTCTG	0.587													A	75042134	A	A	75042134	3	1	99	1	0	0	0	0	1	0	0	0	4150	1319	46	3	57	3	CYP1A2	15	75042134	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08		75042134	27489258	31	6801											
DNAH3	55567	broad.mit.edu	37	chr16	21080790	21080790	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaatgccaaatttcctcccCtcttctggcatctgggctat	6	14	3	0			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr16:21080790C>T	uc010vbe.1	-	23	3327	c.3327G>A	c.(3325-3327)GAG>GAA	p.E1109E		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1109	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATTTCCTCCCCTCTTCTGGCA	0.428													T	21080790	T	T	21080790	2	4	99	1	0	0	0	0	0	0	0	1	4603	680	24	3		3	DNAH3	16	21080790	Silent	SNP	C	TCGA-06-6389-01A-11D-1696-08		21080790	69273963	32	6802											
HYDIN	54768	broad.mit.edu	37	chr16	70977832	70977832	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcggtggatgggccccggGgggagagggctggaggaaat	22	7	0	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr16:70977832G>A	uc002ezr.2	-	42	6677	c.6549C>T	c.(6547-6549)CCC>CCT	p.P2183P		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2184										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TGGGCCCCGGGGGGAGAGGGC	0.368													A	70977832	A	A	70977832	2	1	99	1	0	0	0	0	0	0	0	1	7467	1219	43	3		3	HYDIN	16	70977832	Silent	SNP	G	TCGA-06-6389-01A-11D-1696-08	49897042	70977832	19376921	33	6803											
C16orf3	750	broad.mit.edu	37	chr16	90095609	90095609	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaggctatggggcagcctaCggggcaggctacggggcagg	20	10	0	0	rs76322535		TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr16:90095609C>T	uc002fqk.1	-	1	701	c.142G>A	c.(142-144)GTA>ATA	p.V48I	GAS8_uc010vps.1_Intron|GAS8_uc002fqh.2_Intron|GAS8_uc010vpt.1_Intron|GAS8_uc010vpu.1_Intron|GAS8_uc010vpv.1_Intron|GAS8_uc010cjc.1_Intron|GAS8_uc002fqi.1_Intron|GAS8_uc010vpw.1_Intron|GAS8_uc002fqj.1_Intron	NM_001214	NP_001205	O95177	CP003_HUMAN	hypothetical protein LOC750	48											0		all_cancers(9;9.01e-08)|Hepatocellular(780;0.000325)|Lung NSC(15;0.0104)|all_lung(18;0.0239)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		gggcagcctacggggcaggct	0.303													T	90095609	T	T	90095609	3	4	99	1	0	0	0	0	1	0	0	0	1812	536	19	1	215	1	C16orf3	16	90095609	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08	19117777	90095609	259144	34	6804											
TP53	7157	broad.mit.edu	37	chr17	7578190	7578190	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accagacctcaggcggctcaTagggcaccaccacactatgt	9	15	2	1	rs121912666		TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr17:7578190T>C	uc002gim.2	-	6	853	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(205)|p.Y220N(12)|p.Y220H(9)|p.Y220S(9)|p.0?(7)|p.Y220fs*27(4)|p.Y220*(3)|p.Y220D(2)|p.Y127C(2)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*1(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578190	C	C	7578190	3	2	99	1	0	0	0	0	1	0	0	0	16378	1406	49	4	635	4	TP53	17	7578190	Missense_Mutation	SNP	T	TCGA-06-6389-01A-11D-1696-08		7578190	73617020	35	6805											
MFSD6L	162387	broad.mit.edu	37	chr17	8700984	8700984	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcagagccctctccatgcgGggagtggccaggtcctctac	12	15	3	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr17:8700984G>A	uc002glp.1	-	1	1603	c.1455C>T	c.(1453-1455)CCC>CCT	p.P485P		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	485						integral to membrane				central_nervous_system(1)	1						TCTCCATGCGGGGAGTGGCCA	0.607													A	8700984	A	A	8700984	2	1	99	1	0	0	0	0	0	0	0	1	9536	1219	43	3		3	MFSD6L	17	8700984	Silent	SNP	G	TCGA-06-6389-01A-11D-1696-08	1122794	8700984	72494226	36	6806											
PAK4	10298	broad.mit.edu	37	chr19	39663979	39663979	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggccctttaacacctaccCgagggctgacacggaccacc	9	18	0	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr19:39663979C>T	uc002okj.1	+	5	1087	c.626C>T	c.(625-627)CCG>CTG	p.P209L	PAK4_uc002okl.1_Missense_Mutation_p.P209L|PAK4_uc002okn.1_Missense_Mutation_p.P209L|PAK4_uc002okm.1_Intron|PAK4_uc002oko.1_Intron|PAK4_uc002okp.1_Intron	NM_001014831	NP_001014831	O96013	PAK4_HUMAN	p21-activated kinase 4 isoform 1	209	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			AACACCTACCCGAGGGCTGAC	0.701													T	39663979	T	T	39663979	3	4	99	1	0	0	0	0	1	0	0	0	11403	652	23	2	632	2	PAK4	19	39663979	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08		39663979	19465004	37	6807											
SIRPB1	10326	broad.mit.edu	37	chr20	1600539	1600539	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gagtctccccagcagtagcgTcatcagcaggaaaggactag	12	11	3	0			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr20:1600539T>A	uc010gai.2	-	1	151	c.52A>T	c.(52-54)ACG>TCG	p.T18S	SIRPB1_uc002wfk.3_Missense_Mutation_p.T18S|SIRPB1_uc002wfl.3_Missense_Mutation_p.T18S	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	18					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						AGCAGTAGCGTCATCAGCAGG	0.567													A	1600539	A	A	1600539	3	1	99	1	0	0	0	0	1	0	0	0	14333	1667	58	5	2301	5	SIRPB1	20	1600539	Missense_Mutation	SNP	T	TCGA-06-6389-01A-11D-1696-08		1600539	61424981	38	6808											
PLAGL2	5326	broad.mit.edu	37	chr20	30785118	30785118	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acggcctgtgtgcaccactaGgtgccgccgtacatccttac	10	15	0	0			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr20:30785118G>C	uc002wxn.2	-	3	845	c.628C>G	c.(628-630)CTA>GTA	p.L210V		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	210	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TGCACCACTAGGTGCCGCCGT	0.612													C	30785118	C	C	30785118	3	2	99	1	0	0	0	0	1	0	0	0	12020	991	35	5	866	5	PLAGL2	20	30785118	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08	29184579	30785118	32240402	39	6809											
PPDPF	79144	broad.mit.edu	37	chr20	62153045	62153045	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccccaaggctgacccgggtcAttggtgggccagcttctttt	12	13	2	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr20:62153045A>C	uc002yff.2	+	4	298	c.158A>C	c.(157-159)CAT>CCT	p.H53P		NM_024299	NP_077275	Q9H3Y8	PPDPF_HUMAN	pancreatic progenitor cell differentiation and	53					cell differentiation|multicellular organismal development						0						GACCCGGGTCATTGGTGGGCC	0.637													C	62153045	C	C	62153045	3	2	99	1	0	0	0	0	1	0	0	0	12306	217	8	5	168	5	PPDPF	20	62153045	Missense_Mutation	SNP	A	TCGA-06-6389-01A-11D-1696-08	31367927	62153045	872475	40	6810											
C21orf91	54149	broad.mit.edu	37	chr21	19169182	19169182	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtgggagtaatttttcttcTggcttatgcctgaaattaaa	9	5	2	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr21:19169182T>C	uc002yko.3	-	3	472	c.381A>G	c.(379-381)CCA>CCG	p.P127P	C21orf91_uc002ykq.3_Silent_p.P127P|C21orf91_uc002ykp.3_Silent_p.P127P	NM_001100420	NP_001093890	Q9NYK6	EURL_HUMAN	early undifferentiated retina and lens isoform	127										ovary(1)	1				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		ATTTTTCTTCTGGCTTATGCC	0.383													C	19169182	C	C	19169182	2	2	99	1	0	0	0	0	0	0	0	1	2134	1567	55	4		4	C21orf91	21	19169182	Silent	SNP	T	TCGA-06-6389-01A-11D-1696-08		19169182	28960713	41	6811											
KRTAP22-1	337979	broad.mit.edu	37	chr21	31973461	31973461	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagctttgataacaactacCatggtggccagggctatgcc	11	10	0	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr21:31973461C>T	uc011add.1	+	1	22	c.22C>T	c.(22-24)CAT>TAT	p.H8Y	KRTAP6-2_uc011adc.1_5'Flank	NM_181620	NP_853651	Q3MIV0	KR221_HUMAN	keratin associated protein 22-1	8						intermediate filament					0						TAACAACTACCATGGTGGCCA	0.423													T	31973461	T	T	31973461	3	4	99	1	0	0	0	0	1	0	0	0	8540	594	21	3	24	3	KRTAP22-1	21	31973461	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08	12804279	31973461	16156434	42	6812											
APOBEC3B	9582	broad.mit.edu	37	chr22	39382073	39382073	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgagtcaggcaggagcccGcgtgacgatcatggactatg	15	10	2	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr22:39382073G>A	uc003awo.1	+	3	485	c.431G>A	c.(430-432)CGC>CAC	p.R144H	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Missense_Mutation_p.R144H|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	144					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					GCAGGAGCCCGCGTGACGATC	0.587													A	39382073	A	A	39382073	3	1	99	1	0	0	0	0	1	0	0	0	790	1087	38	1	441	1	APOBEC3B	22	39382073	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08		39382073	11922493	43	6813											
CELSR1	9620	broad.mit.edu	37	chr22	46805742	46805742	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgcctccattctgacaccGcctcccatcgcagaagttcc	8	17	1	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chr22:46805742G>A	uc003bhw.1	-	8	4969	c.4969C>T	c.(4969-4971)CGG>TGG	p.R1657W	CELSR1_uc011arc.1_5'Flank	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1657	Extracellular (Potential).|EGF-like 4; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TTCTGACACCGCCTCCCATCG	0.622													A	46805742	A	A	46805742	3	1	99	1	0	0	0	0	1	0	0	0	3221	1086	38	1	4187	1	CELSR1	22	46805742	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08	7423669	46805742	4498824	44	6814											
ACE2	59272	broad.mit.edu	37	chrX	15589843	15589843	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagttgagcagtggccttaCattcatgttctttgctccta	9	9	2	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chrX:15589843C>T	uc004cxa.1	-	13	1909	c.1741G>A	c.(1741-1743)GTA>ATA	p.V581I	ACE2_uc004cxb.2_Missense_Mutation_p.V581I	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	581	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	AGTGGCCTTACATTCATGTTC	0.448													T	15589843	T	T	15589843	3	4	99	1	0	0	0	0	1	0	0	0	137	478	17	3	700	3	ACE2	23	15589843	Missense_Mutation	SNP	C	TCGA-06-6389-01A-11D-1696-08		15589843	139680717	45	6815											
DMD	1756	broad.mit.edu	37	chrX	32490283	32490283	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	attcaaatattcacagacctGcaattccccgagtctctgct	5	13	3	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chrX:32490283G>C	uc004dda.1	-	22	3191	c.2947C>G	c.(2947-2949)CAG>GAG	p.Q983E	DMD_uc004dcz.2_Missense_Mutation_p.Q860E|DMD_uc004dcy.1_Missense_Mutation_p.Q979E|DMD_uc004ddb.1_Missense_Mutation_p.Q975E|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	983	Spectrin 6.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCACAGACCTGCAATTCCCCG	0.388													C	32490283	C	C	32490283	3	2	99	1	0	0	0	0	1	0	0	0	4580	1328	46	5	8585	5	DMD	23	32490283	Missense_Mutation	SNP	G	TCGA-06-6389-01A-11D-1696-08	16900440	32490283	122780277	46	6816											
PHKA1	5255	broad.mit.edu	37	chrX	71843109	71843109	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgttgtcaaaaactctgacaAtttacctgtttgaaccctaa	5	9	2	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chrX:71843109A>G	uc004eax.3	-	18	2111	c.1810T>C	c.(1810-1812)TTG>CTG	p.L604L	PHKA1_uc004eay.3_Silent_p.L604L|PHKA1_uc011mqi.1_Silent_p.L604L	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	604					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					AACTCTGACAATTTACCTGTT	0.383													G	71843109	G	G	71843109	2	3	99	1	0	0	0	0	0	0	0	1	11843	98	4	4		4	PHKA1	23	71843109	Silent	SNP	A	TCGA-06-6389-01A-11D-1696-08	39352826	71843109	83427451	47	6817											
P2RY10	27334	broad.mit.edu	37	chrX	78216344	78216344	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagccctttgcctgctctgCttctacctgaagtatctcaa	7	13	3	2			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chrX:78216344C>T	uc004ede.2	+	4	696	c.327C>T	c.(325-327)TGC>TGT	p.C109C	P2RY10_uc004edf.2_Silent_p.C109C	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	109	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						GCCTGCTCTGCTTCTACCTGA	0.483													T	78216344	T	T	78216344	2	4	99	1	0	0	0	0	0	0	0	1	11347	805	28	3		3	P2RY10	23	78216344	Silent	SNP	C	TCGA-06-6389-01A-11D-1696-08	6373235	78216344	77054216	48	6818											
COL4A6	1288	broad.mit.edu	37	chrX	107435807	107435807	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtacaccaggatctccaggaTtacctggcattgtaatgaaa	9	9	1	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chrX:107435807T>C	uc004enw.3	-	18	1182	c.1079A>G	c.(1078-1080)AAT>AGT	p.N360S	COL4A6_uc004env.3_Missense_Mutation_p.N359S|COL4A6_uc011msn.1_Missense_Mutation_p.N359S|COL4A6_uc010npk.2_Missense_Mutation_p.N359S	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	360	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						ATCTCCAGGATTACCTGGCAT	0.502									Alport_syndrome_with_Diffuse_Leiomyomatosis				C	107435807	C	C	107435807	3	2	99	1	0	0	0	0	1	0	0	0	3695	1493	52	4	4108	4	COL4A6	23	107435807	Missense_Mutation	SNP	T	TCGA-06-6389-01A-11D-1696-08	29219463	107435807	47834753	49	6819											
GABRQ	55879	broad.mit.edu	37	chrX	151820028	151820028	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctgaccaccatcgactcacAtctgcgggataagctcccca	7	17	2	1			TCGA-06-6389-01A-11D-1696-08	TCGA-06-6389-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	10911471-5404-42d5-817e-f9616e7dacfc	82fae444-2e87-4c4b-b657-614c55211ed6	g.chrX:151820028A>C	uc004ffp.1	+	8	961	c.941A>C	c.(940-942)CAT>CCT	p.H314P		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	314						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATCGACTCACATCTGCGGGAT	0.468													C	151820028	C	C	151820028	3	2	99	1	0	0	0	0	1	0	0	0	6175	217	8	5	971	5	GABRQ	23	151820028	Missense_Mutation	SNP	A	TCGA-06-6389-01A-11D-1696-08	44384221	151820028	3450532	50	6820											
SLC30A7	148867	broad.mit.edu	37	chr1	101379278	101379278	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	atcaggcacatggccatgtcGatcattgccatagccatgaa	9	11	2	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr1:101379278G>T	uc001dtn.2	+	6	758	c.571G>T	c.(571-573)GAT>TAT	p.D191Y	SLC30A7_uc001dto.2_Missense_Mutation_p.D191Y	NM_001144884	NP_001138356	Q8NEW0	ZNT7_HUMAN	zinc transporter like 2	191	Cytoplasmic (Potential).|His-rich loop.				zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)		TGGCCATGTCGATCATTGCCA	0.443													T	101379278	T	T	101379278	3	4	100	1	0	0	0	0	1	0	0	0	14560	1058	37	5	593	5	SLC30A7	1	101379278	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08		101379278	147871343	1	6821											
NPL	80896	broad.mit.edu	37	chr1	182787959	182787959	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctgattagcaactgttgagTgctctggtgatgggagcaac	13	7	2	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr1:182787959T>G	uc009wyb.2	+	10	758	c.618T>G	c.(616-618)AGT>AGG	p.S206R	NPL_uc010pnx.1_Intron|NPL_uc010pny.1_RNA|NPL_uc001gpo.1_Missense_Mutation_p.S187R|NPL_uc009wyc.2_Intron|NPL_uc001gpp.3_Missense_Mutation_p.S206R|NPL_uc001gpq.1_Missense_Mutation_p.S206R	NM_030769	NP_110396	Q9BXD5	NPL_HUMAN	N-acetylneuraminate pyruvate lyase	206					carbohydrate metabolic process	cytoplasm	N-acetylneuraminate lyase activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AACTGTTGAGTGCTCTGGTGA	0.393													G	182787959	G	G	182787959	3	3	100	1	0	0	0	0	1	0	0	0	10585	1693	59	5	648	5	NPL	1	182787959	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08	81408681	182787959	66462662	2	6822											
AHCTF1	25909	broad.mit.edu	37	chr1	247024397	247024397	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aaggtagtctcatcggatgtGattgaaacactgctgtttcc	10	8	1	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr1:247024397G>A	uc001ibu.1	-	28	3943	c.3936C>T	c.(3934-3936)ATC>ATT	p.I1312I	AHCTF1_uc001ibv.1_Silent_p.I1321I|AHCTF1_uc009xgs.1_Silent_p.I173I|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1312	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CATCGGATGTGATTGAAACAC	0.463													A	247024397	A	A	247024397	2	1	100	1	0	0	0	0	0	0	0	1	408	1280	45	3		3	AHCTF1	1	247024397	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08	64236438	247024397	2226224	3	6823											
NLRP3	114548	broad.mit.edu	37	chr1	247586553	247586553	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcagataatgcacgtgtttCgaatcccactgtgatatgcc	8	10	1	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr1:247586553C>T	uc001icr.2	+	4	443	c.305C>T	c.(304-306)TCG>TTG	p.S102L	NLRP3_uc001ics.2_Missense_Mutation_p.S102L|NLRP3_uc001icu.2_Missense_Mutation_p.S102L|NLRP3_uc001icw.2_Missense_Mutation_p.S102L|NLRP3_uc001icv.2_Missense_Mutation_p.S102L|NLRP3_uc010pyw.1_Missense_Mutation_p.S100L|NLRP3_uc001ict.1_Missense_Mutation_p.S100L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	102					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding	p.S102S(1)		lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCACGTGTTTCGAATCCCACT	0.403													T	247586553	T	T	247586553	3	4	100	1	0	0	0	0	1	0	0	0	10478	893	31	2	311	2	NLRP3	1	247586553	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08	562156	247586553	1664068	4	6824											
TTN	7273	broad.mit.edu	37	chr2	179596192	179596192	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgtcttcagtgatttcatcGctgtcttttagccaagtcac	7	11	5	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr2:179596192G>A	uc010zfg.1	-	56	13793	c.13569C>T	c.(13567-13569)AGC>AGT	p.S4523S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.S1184S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5450							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATTTCATCGCTGTCTTTTA	0.483													A	179596192	A	A	179596192	2	1	100	1	0	0	0	0	0	0	0	1	16732	1078	38	1		1	TTN	2	179596192	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08		179596192	63603181	5	6825											
QARS	5859	broad.mit.edu	37	chr3	49142151	49142151	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctagtgaagagcgacagggAgtctagagccgccattgcag	15	9	1	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr3:49142151A>G	uc003cvx.2	-	1	21	c.16T>C	c.(16-18)TCC>CCC	p.S6P	QARS_uc011bcd.1_5'Flank|QARS_uc003cvy.2_5'UTR|QARS_uc011bce.1_Missense_Mutation_p.S6P|QARS_uc011bcf.1_Missense_Mutation_p.S6P	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	6					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AGCGACAGGGAGTCTAGAGCC	0.602													G	49142151	G	G	49142151	3	3	100	1	0	0	0	0	1	0	0	0	12871	304	11	4	2407	4	QARS	3	49142151	Missense_Mutation	SNP	A	TCGA-06-6390-01A-11D-1696-08		49142151	148880279	6	6826											
UBA7	7318	broad.mit.edu	37	chr3	49847050	49847050	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccagtggccaagagcccaCgccacacagtcttgccagtt	9	15	1	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr3:49847050C>T	uc003cxr.2	-	16	2184	c.2013G>A	c.(2011-2013)GCG>GCA	p.A671A		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	671					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		CAAGAGCCCACGCCACACAGT	0.547													T	49847050	T	T	49847050	2	4	100	1	0	0	0	0	0	0	0	1	16830	523	19	1		1	UBA7	3	49847050	Silent	SNP	C	TCGA-06-6390-01A-11D-1696-08	704899	49847050	148175380	7	6827											
ABCC5	10057	broad.mit.edu	37	chr3	183677612	183677612	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtgaaccactggtttccttTtttgaattgatctaataata	6	6	1	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr3:183677612T>C	uc003fmg.2	-	17	2556	c.2391A>G	c.(2389-2391)AAA>AAG	p.K797K	ABCC5_uc011bqt.1_Silent_p.K325K|ABCC5_uc010hxl.2_Silent_p.K797K	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	797						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGGTTTCCTTTTTTGAATTGA	0.363													C	183677612	C	C	183677612	2	2	100	1	0	0	0	0	0	0	0	1	56	1838	64	4		4	ABCC5	3	183677612	Silent	SNP	T	TCGA-06-6390-01A-11D-1696-08	133830562	183677612	14344818	8	6828											
ZNF595	152687	broad.mit.edu	37	chr4	85691	85691	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agattcattccacaaacttaTactgaaaagatacgagaaat	5	7	1	4			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr4:85691T>C	uc003fzv.1	+	4	452	c.296T>C	c.(295-297)ATA>ACA	p.I99T	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_5'UTR	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	99					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		CACAAACTTATACTGAAAAGA	0.353													C	85691	C	C	85691	3	2	100	1	0	0	0	0	1	0	0	0	18022	1406	49	4	310	4	ZNF595	4	85691	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08		85691	191068585	9	6829											
FAM193A	8603	broad.mit.edu	37	chr4	2733554	2733554	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaagactgtctatcaactggTccaattttagcttgaaaaaa	6	7	2	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr4:2733554T>C	uc010icl.2	+	20	4108	c.3757T>C	c.(3757-3759)TCC>CCC	p.S1253P	FAM193A_uc010ick.2_Missense_Mutation_p.S1412P|FAM193A_uc003gfd.2_Missense_Mutation_p.S1212P|FAM193A_uc011bvm.1_Missense_Mutation_p.S1234P|FAM193A_uc011bvn.1_3'UTR|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	1253										ovary(3)	3						TATCAACTGGTCCAATTTTAG	0.517													C	2733554	C	C	2733554	3	2	100	1	0	0	0	0	1	0	0	0	5524	1667	58	4	3700	4	FAM193A	4	2733554	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08	2647863	2733554	188420722	10	6830											
PRKG2	5593	broad.mit.edu	37	chr4	82063966	82063966	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acaagctcaactcttccgaaCccaccaacgcccagtgttgc	6	17	2	0			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr4:82063966C>A	uc003hmh.2	-	10	1403	c.1389G>T	c.(1387-1389)GGG>GGT	p.G463G	PRKG2_uc011ccf.1_Silent_p.G43G|PRKG2_uc011ccg.1_Silent_p.G43G|PRKG2_uc011cch.1_Intron	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	463	Protein kinase.|ATP (By similarity).				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						CTCTTCCGAACCCACCAACGC	0.428													A	82063966	A	A	82063966	2	1	100	1	0	0	0	0	0	0	0	1	12523	494	18	5		5	PRKG2	4	82063966	Silent	SNP	C	TCGA-06-6390-01A-11D-1696-08	79330412	82063966	109090310	11	6831											
FAT1	2195	broad.mit.edu	37	chr4	187630082	187630082	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ctcactgttctaaactgctgGagaaggtcacctgccacgat	9	12	3	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr4:187630082G>T	uc003izf.2	-	2	1088	c.900C>A	c.(898-900)CTC>CTA	p.L300L	FAT1_uc010iso.1_Silent_p.L300L	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	300	Extracellular (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TAAACTGCTGGAGAAGGTCAC	0.493										HNSCC(5;0.00058)			T	187630082	T	T	187630082	2	4	100	1	0	0	0	0	0	0	0	1	5689	1161	41	5		5	FAT1	4	187630082	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08	105566116	187630082	3524194	12	6832											
GABRA6	2559	broad.mit.edu	37	chr5	161119060	161119060	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagctgtttgctttgcattcGtcttctctgcgcttatcgag	9	10	2	0			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr5:161119060G>A	uc003lyu.2	+	8	1278	c.940G>A	c.(940-942)GTC>ATC	p.V314I	GABRA6_uc003lyv.2_Missense_Mutation_p.V85I	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	314	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity	p.V314I(1)		ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTTTGCATTCGTCTTCTCTGC	0.478										TCGA Ovarian(5;0.080)			A	161119060	A	A	161119060	3	1	100	1	0	0	0	0	1	0	0	0	6165	1145	40	1	970	1	GABRA6	5	161119060	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08		161119060	19796200	13	6833											
ZNF354C	30832	broad.mit.edu	37	chr5	178506220	178506220	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gatcatcccttctttctcatCagagaattcatactggagag	7	10	5	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr5:178506220C>G	uc003mju.2	+	5	902	c.787C>G	c.(787-789)CAG>GAG	p.Q263E		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	263	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		TCTTTCTCATCAGAGAATTCA	0.388													G	178506220	G	G	178506220	3	3	100	1	0	0	0	0	1	0	0	0	17863	827	29	5	801	5	ZNF354C	5	178506220	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08	17387160	178506220	2409040	14	6834			1	23		3	3	346	C		1.941031e-07
ZNF354C	30832	broad.mit.edu	37	chr5	178506472	178506472	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gagcaaaacttcacaggcatCaaagaatccatacaggtgag	9	9	2	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr5:178506472C>G	uc003mju.2	+	5	1154	c.1039C>G	c.(1039-1041)CAA>GAA	p.Q347E		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	347	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		TCACAGGCATCAAAGAATCCA	0.428													G	178506472	G	G	178506472	3	3	100	1	0	0	0	0	1	0	0	0	17863	827	29	5	1053	5	ZNF354C	5	178506472	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08	252	178506472	2408788	15	6835			1	23		3	3	346	C		1.941031e-07
ZNF354C	30832	broad.mit.edu	37	chr5	178506565	178506565	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tagctgaacatcagaggtttCatactggagaacaactgtat	9	7	2	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr5:178506565C>A	uc003mju.2	+	5	1247	c.1132C>A	c.(1132-1134)CAT>AAT	p.H378N		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	378	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		TCAGAGGTTTCATACTGGAGA	0.428													A	178506565	A	A	178506565	3	1	100	1	0	0	0	0	1	0	0	0	17863	826	29	5	1146	5	ZNF354C	5	178506565	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08	93	178506565	2408695	16	6836			1	23		3	3	346	C		1.941031e-07
FTSJD2	23070	broad.mit.edu	37	chr6	37446254	37446254	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacacagggcgtgatgaccgGcactttgtacccatgggcct	12	12	0	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr6:37446254G>A	uc003ons.2	+	22	2476	c.2223G>A	c.(2221-2223)CGG>CGA	p.R741R		NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	741	Interaction with POLR2A.				mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GTGATGACCGGCACTTTGTAC	0.587													A	37446254	A	A	37446254	2	1	100	1	0	0	0	0	0	0	0	1	6091	1190	42	3		3	FTSJD2	6	37446254	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08		37446254	133668813	17	6837											
IGFBP1	3484	broad.mit.edu	37	chr7	45930223	45930223	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gataatttccatctgatggcCccttctgaagaggatcattc	8	10	3	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr7:45930223C>T	uc003tnp.2	+	2	719	c.426C>T	c.(424-426)GCC>GCT	p.A142A	IGFBP1_uc003tno.3_Silent_p.A142A|IGFBP1_uc010kyn.2_Silent_p.A142A	NM_000596	NP_000587	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	142						extracellular space	insulin-like growth factor binding			lung(1)	1						ATCTGATGGCCCCTTCTGAAG	0.517											OREG0018048	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	45930223	T	T	45930223	2	4	100	1	0	0	0	0	0	0	0	1	7578	610	22	3		3	IGFBP1	7	45930223	Silent	SNP	C	TCGA-06-6390-01A-11D-1696-08		45930223	113208440	18	6838											
SEPT14	346288	broad.mit.edu	37	chr7	55910809	55910809	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgggcatctatgtagtcaacTattggttggtagctaaaaaa	10	5	2	0			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr7:55910809T>C	uc003tqz.2	-	5	501	c.384A>G	c.(382-384)ATA>ATG	p.I128M		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	128					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGTAGTCAACTATTGGTTGGT	0.358													C	55910809	C	C	55910809	3	2	100	1	0	0	0	0	1	0	0	0	14063	1512	53	4	938	4	SEPT14	7	55910809	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08	9980586	55910809	103227854	19	6839											
KIAA1324L	222223	broad.mit.edu	37	chr7	86526910	86526910	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagcactctcccacaggaaaTagaacgtacacccatcacag	6	15	2	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr7:86526910T>C	uc011kha.1	-	19	2782	c.2597A>G	c.(2596-2598)TAT>TGT	p.Y866C	KIAA1324L_uc003uif.1_Missense_Mutation_p.Y626C|KIAA1324L_uc011kgz.1_Missense_Mutation_p.Y752C|KIAA1324L_uc003uie.2_Missense_Mutation_p.Y699C	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	866	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					CCACAGGAAATAGAACGTACA	0.453													C	86526910	C	C	86526910	3	2	100	1	0	0	0	0	1	0	0	0	8224	1406	49	4	508	4	KIAA1324L	7	86526910	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08	30616101	86526910	72611753	20	6840											
LY96	23643	broad.mit.edu	37	chr8	74941281	74941281	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatcctacaccaacctaatTcaaattagaataaattgagt	3	9	2	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr8:74941281T>C	uc003yad.2	+	5	566	c.475T>C	c.(475-477)TCA>CCA	p.S159P		NM_015364	NP_056179	Q9Y6Y9	LY96_HUMAN	MD-2 protein precursor	159					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			CCAACCTAATTCAAATTAGAA	0.234													C	74941281	C	C	74941281	3	2	100	1	0	0	0	0	1	0	0	0	9102	1783	62	4	493	4	LY96	8	74941281	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08		74941281	71422741	21	6841											
RUNX1T1	862	broad.mit.edu	37	chr8	93017373	93017373	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcgcctcttcccgttttcGttcacatcgagaagcagctc	8	14	2	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr8:93017373G>A	uc003yfd.2	-	5	795	c.711C>T	c.(709-711)AAC>AAT	p.N237N	RUNX1T1_uc003yfc.1_Silent_p.N210N|RUNX1T1_uc003yfe.1_Silent_p.N200N|RUNX1T1_uc010mao.2_Silent_p.N210N|RUNX1T1_uc011lgi.1_Silent_p.N248N|RUNX1T1_uc003yfb.1_Silent_p.N200N|RUNX1T1_uc003yff.1_Silent_p.N200N	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	237					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCCCGTTTTCGTTCACATCGA	0.537													A	93017373	A	A	93017373	2	1	100	1	0	0	0	0	0	0	0	1	13747	1136	40	1		1	RUNX1T1	8	93017373	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08	18076092	93017373	53346649	22	6842											
DENND3	22898	broad.mit.edu	37	chr8	142186755	142186755	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actttaaaaatcagagtggcGtccaagaaagaagtcttcga	9	7	2	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr8:142186755G>A	uc003yvy.2	+	15	2639	c.2361G>A	c.(2359-2361)GCG>GCA	p.A787A	DENND3_uc010mep.2_Silent_p.A748A	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	787										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TCAGAGTGGCGTCCAAGAAAG	0.483													A	142186755	A	A	142186755	2	1	100	1	0	0	0	0	0	0	0	1	4432	1132	40	1		1	DENND3	8	142186755	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08	49169382	142186755	4177267	23	6843											
EPPK1	83481	broad.mit.edu	37	chr8	144945189	144945189	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgatcgaagtagccgcgccGgtaggccacgtccacgggca	14	14	0	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr8:144945189G>A	uc003zaa.1	-	1	2246	c.2233C>T	c.(2233-2235)CGG>TGG	p.R745W		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	745	Plectin 14.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TAGCCGCGCCGGTAGGCCACG	0.652													A	144945189	A	A	144945189	3	1	100	1	0	0	0	0	1	0	0	0	5190	1115	39	2	5033	2	EPPK1	8	144945189	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08	2758434	144945189	1418833	24	6844											
SH3GL2	6456	broad.mit.edu	37	chr9	17791242	17791242	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgcagattgaacaagtgaGccagctctctgcacttgtgc	10	11	2	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr9:17791242G>A	uc003zna.2	+	7	926	c.638G>A	c.(637-639)AGC>AAC	p.S213N	SH3GL2_uc011lmy.1_Missense_Mutation_p.S166N	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	213	BAR.|Potential.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GAACAAGTGAGCCAGCTCTCT	0.478													A	17791242	A	A	17791242	3	1	100	1	0	0	0	0	1	0	0	0	14251	971	34	3	664	3	SH3GL2	9	17791242	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08		17791242	123422189	25	6845											
CYLC2	1539	broad.mit.edu	37	chr9	105767006	105767006	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaagaacaattaagaggagaTcgtagacaaccattatggat	10	5	0	4			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr9:105767006T>C	uc004bbs.2	+	4	280	c.210T>C	c.(208-210)GAT>GAC	p.D70D		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	70	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				TAAGAGGAGATCGTAGACAAC	0.358													C	105767006	C	C	105767006	2	2	100	1	0	0	0	0	0	0	0	1	4142	1432	50	4		4	CYLC2	9	105767006	Silent	SNP	T	TCGA-06-6390-01A-11D-1696-08	87975764	105767006	35446425	26	6846											
OR9I1	219954	broad.mit.edu	37	chr11	57886023	57886023	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcgacctttctgaaggcgtcTtttacatctttgtttcttaa	7	9	4	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr11:57886023T>A	uc001nml.1	-	1	894	c.894A>T	c.(892-894)AAA>AAT	p.K298N	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				TGAAGGCGTCTTTTACATCTT	0.438													A	57886023	A	A	57886023	3	1	100	1	0	0	0	0	1	0	0	0	11253	1606	56	5	54	5	OR9I1	11	57886023	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08		57886023	77120493	27	6847											
C11orf20	25858	broad.mit.edu	37	chr11	64070987	64070987	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgtcatcactcaatattgCgaagcacatgccccatcgag	7	12	3	0			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr11:64070987C>T	uc009ypm.2	+	3	406	c.386C>T	c.(385-387)GCG>GTG	p.A129V	KCNK4_uc001nzm.3_RNA|ESRRA_uc001nzq.1_5'Flank|ESRRA_uc001nzr.1_5'Flank|ESRRA_uc001nzs.1_5'Flank	NM_001039496	NP_001034585	Q9NTU4	CK020_HUMAN	hypothetical protein LOC25858	129					cell differentiation|spermatogenesis	cytoplasm					0						CTCAATATTGCGAAGCACATG	0.552													T	64070987	T	T	64070987	3	4	100	1	0	0	0	0	1	0	0	0	1634	768	27	1	396	1	C11orf20	11	64070987	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08	6184964	64070987	70935529	28	6848											
OR10G8	219869	broad.mit.edu	37	chr11	123901241	123901243	+	In_Frame_Del	DEL	AGT	-	-													ctgttgaagctgaaagacaaAgtagcacattctcagagcaa							TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr11:123901241_123901243delAGT	uc001pzp.1	+	1	912_914	c.912_914delAGT	c.(910-915)AAAGTA>AAA	p.V305del		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGAAAGACAAAGTAGCACATTCT	0.291													-	123901243	-	-	123901241	7	5	100	1	0	1	0	1	0	0	0	0	10903	69	3	0	914	0	OR10G8	11	123901241	In_Frame_Del	DEL	AGT	TCGA-06-6390-01A-11D-1696-08	59830254	123901241	11105275	29	6849											
KIRREL3	84623	broad.mit.edu	37	chr11	126299112	126299112	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggagtgctcctcaccctcccGaccagaggctggttccttgt	11	15	1	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr11:126299112G>A	uc001qea.2	-	15	2129	c.1768C>T	c.(1768-1770)CGG>TGG	p.R590W	KIRREL3_uc001qeb.2_Missense_Mutation_p.R578W|ST3GAL4_uc001qdx.1_Intron	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	590	Cytoplasmic (Potential).				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		TCACCCTCCCGACCAGAGGCT	0.488													A	126299112	A	A	126299112	3	1	100	1	0	0	0	0	1	0	0	0	8326	1057	37	2	580	2	KIRREL3	11	126299112	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08	2397871	126299112	8707404	30	6850											
TAS2R20	259295	broad.mit.edu	37	chr12	11150018	11150018	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttcacattcttctgtccacaCatttatatacgtgtgtttca	4	10	4	0			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr12:11150018C>G	uc001qzm.2	-	1	457	c.457G>C	c.(457-459)GTG>CTG	p.V153L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176889	NP_795370	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	153	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						TCTGTCCACACATTTATATAC	0.398													G	11150018	G	G	11150018	3	3	100	1	0	0	0	0	1	0	0	0	15568	478	17	5	476	5	TAS2R20	12	11150018	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08		11150018	122701877	31	6851											
EPS8	2059	broad.mit.edu	37	chr12	15807133	15807133	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acagctgccgttcatcaccaTtgacagtataatttaagaaa	6	9	2	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr12:15807133T>C	uc009zif.2	-	13	1290	c.1196A>G	c.(1195-1197)AAT>AGT	p.N399S	EPS8_uc001rdb.2_Missense_Mutation_p.N399S|EPS8_uc009zig.2_Missense_Mutation_p.N139S|EPS8_uc010shv.1_Missense_Mutation_p.N139S	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	399	PH; second part.				cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		TTCATCACCATTGACAGTATA	0.418													C	15807133	C	C	15807133	3	2	100	1	0	0	0	0	1	0	0	0	5194	1493	52	4	1308	4	EPS8	12	15807133	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08	4657115	15807133	118044762	32	6852											
PA2G4	5036	broad.mit.edu	37	chr12	56501039	56501039	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttgtggttgatgtagctcAggtaggtggcctgcttttga	14	5	1	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr12:56501039A>G	uc001sjm.2	+	4	811	c.392A>G	c.(391-393)CAG>CGG	p.Q131R	PA2G4_uc009zol.2_Missense_Mutation_p.Q131R|PA2G4_uc009zom.2_Missense_Mutation_p.Q131R	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	131					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			GATGTAGCTCAGGTAGGTGGC	0.488													G	56501039	G	G	56501039	3	3	100	1	0	0	0	0	1	0	0	0	11361	202	7	4	406	4	PA2G4	12	56501039	Missense_Mutation	SNP	A	TCGA-06-6390-01A-11D-1696-08	40693906	56501039	77350856	33	6853											
USP15	9958	broad.mit.edu	37	chr12	62778015	62778015	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gttacttgacacttccattgCccatgaaaaaagaacgcacc	6	12	0	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr12:62778015C>G	uc001src.1	+	11	1414	c.1405C>G	c.(1405-1407)CCC>GCC	p.P469A	USP15_uc001srb.1_Missense_Mutation_p.P440A	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	469					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		ACTTCCATTGCCCATGAAAAA	0.338													G	62778015	G	G	62778015	3	3	100	1	0	0	0	0	1	0	0	0	17043	739	26	5	1356	5	USP15	12	62778015	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08	6276976	62778015	71073880	34	6854											
NAV3	89795	broad.mit.edu	37	chr12	78415582	78415582	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cggctgactcctgtaccagtCctacaaagatggacttatca	8	12	1	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr12:78415582C>G	uc001syp.2	+	9	2136	c.1963C>G	c.(1963-1965)CCT>GCT	p.P655A	NAV3_uc001syo.2_Missense_Mutation_p.P655A	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	655						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTGTACCAGTCCTACAAAGAT	0.413										HNSCC(70;0.22)			G	78415582	G	G	78415582	3	3	100	1	0	0	0	0	1	0	0	0	10185	855	30	5	1997	5	NAV3	12	78415582	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08	15637567	78415582	55436313	35	6855											
TPTE2	93492	broad.mit.edu	37	chr13	20039678	20039678	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcttatcagaataataagtCgtagaagtcgaactaaatgt	7	5	2	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr13:20039678C>T	uc001umd.2	-	9	750	c.539G>A	c.(538-540)CGA>CAA	p.R180Q	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.R69Q|TPTE2_uc001ume.2_Missense_Mutation_p.R103Q|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	180						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		AATAATAAGTCGTAGAAGTCG	0.303													T	20039678	T	T	20039678	3	4	100	1	0	0	0	0	1	0	0	0	16428	884	31	2	1081	2	TPTE2	13	20039678	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08		20039678	95130200	36	6856											
SACS	26278	broad.mit.edu	37	chr13	23908157	23908157	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agctggttggctgaaacagtAaactttgttcctggaagcaa	11	7	0	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr13:23908157A>C	uc001uon.2	-	10	10447	c.9858T>G	c.(9856-9858)TTT>TTG	p.F3286L	SACS_uc001uoo.2_Missense_Mutation_p.F3139L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3286					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTGAAACAGTAAACTTTGTTC	0.408													C	23908157	C	C	23908157	3	2	100	1	0	0	0	0	1	0	0	0	13804	359	13	5	3885	5	SACS	13	23908157	Missense_Mutation	SNP	A	TCGA-06-6390-01A-11D-1696-08	3868479	23908157	91261721	37	6857											
SPATA13	221178	broad.mit.edu	37	chr13	24871773	24871773	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcgtcagtaggaccacagaCgaggtttatttgttttgtgc	11	8	1	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr13:24871773C>T	uc001upg.1	+	10	2015	c.1608C>T	c.(1606-1608)GAC>GAT	p.D536D	SPATA13_uc001upd.1_Silent_p.D1161D|C1QTNF9_uc001upe.2_RNA|SPATA13_uc010tcy.1_Silent_p.D482D|SPATA13_uc010tcz.1_Silent_p.D420D|SPATA13_uc010tda.1_Silent_p.D480D|SPATA13_uc001uph.2_Silent_p.D458D|SPATA13_uc010tdb.1_Silent_p.D396D|SPATA13_uc009zzz.1_Intron|SPATA13_uc001upi.1_Silent_p.D42D	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	536	PH.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GGACCACAGACGAGGTTTATT	0.532													T	24871773	T	T	24871773	2	4	100	1	0	0	0	0	0	0	0	1	14999	535	19	1		1	SPATA13	13	24871773	Silent	SNP	C	TCGA-06-6390-01A-11D-1696-08	963616	24871773	90298105	38	6858											
SLC46A3	283537	broad.mit.edu	37	chr13	29287613	29287613	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctaatagacaaaagtatgaaTgtagacactagaccaggaat	8	6	0	4			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr13:29287613T>A	uc001usi.2	-	2	1234	c.264A>T	c.(262-264)ACA>ACT	p.T88T	SLC46A3_uc001usg.2_Silent_p.T13T|SLC46A3_uc001usj.2_Silent_p.T88T|SLC46A3_uc001ush.2_Silent_p.T88T|SLC46A3_uc001usk.2_Silent_p.T13T	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	88	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		AAAGTATGAATGTAGACACTA	0.378													A	29287613	A	A	29287613	2	1	100	1	0	0	0	0	0	0	0	1	14646	1451	51	5		5	SLC46A3	13	29287613	Silent	SNP	T	TCGA-06-6390-01A-11D-1696-08	4415840	29287613	85882265	39	6859											
VPS18	57617	broad.mit.edu	37	chr15	41191638	41191638	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccagcacctgtgtgctccCttgaggccgagcggggccct	14	15	0	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr15:41191638C>T	uc001zne.2	+	4	961	c.622C>T	c.(622-624)CTT>TTT	p.L208F		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	208					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		TGTGTGCTCCCTTGAGGCCGA	0.617													T	41191638	T	T	41191638	3	4	100	1	0	0	0	0	1	0	0	0	17191	681	24	3	636	3	VPS18	15	41191638	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08		41191638	61339754	40	6860											
UBR1	197131	broad.mit.edu	37	chr15	43317593	43317593	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttaccttcatctttgtttTcttgttttctccttttcttc	2	10	5	0			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr15:43317593T>C	uc001zqq.2	-	24	2636	c.2570A>G	c.(2569-2571)GAA>GGA	p.E857G	UBR1_uc010udk.1_Missense_Mutation_p.E857G	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	857					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ATCTTTGTTTTCTTGTTTTCT	0.299													C	43317593	C	C	43317593	3	2	100	1	0	0	0	0	1	0	0	0	16898	1783	62	4	2775	4	UBR1	15	43317593	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08	2125955	43317593	59213799	41	6861											
GABPB1	2553	broad.mit.edu	37	chr15	50593079	50593079	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaagagtttccaaactgaaCagcagatacacccgtttcat	7	10	1	4	rs147105901	byFrequency	TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr15:50593079C>T	uc001zyb.2	-	6	1064	c.640G>A	c.(640-642)GTT>ATT	p.V214I	GABPB1_uc001zya.2_Missense_Mutation_p.V202I|GABPB1_uc010ufg.1_Missense_Mutation_p.V138I|GABPB1_uc001zyc.2_Missense_Mutation_p.V202I|GABPB1_uc001zyd.2_Missense_Mutation_p.V202I|GABPB1_uc001zye.2_Missense_Mutation_p.V214I|GABPB1_uc001zyf.2_Missense_Mutation_p.V202I	NM_005254	NP_005245	Q06547	GABP1_HUMAN	GA binding protein transcription factor, beta	214					positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)	1						CCAAACTGAACAGCAGATACA	0.348													T	50593079	T	T	50593079	3	4	100	1	0	0	0	0	1	0	0	0	6158	478	17	3	611	3	GABPB1	15	50593079	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08	7275486	50593079	51938313	42	6862											
MEFV	4210	broad.mit.edu	37	chr16	3299649	3299649	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgggggcagccaggtgagcGgctgcctgaggcctgggggt	21	11	0	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr16:3299649G>A	uc002cun.1	-	3	1082	c.1042C>T	c.(1042-1044)CGC>TGC	p.R348C		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	348					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding	p.R348H(1)		central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	CCAGGTGAGCGGCTGCCTGAG	0.657													A	3299649	A	A	3299649	3	1	100	1	0	0	0	0	1	0	0	0	9459	1116	39	2	1335	2	MEFV	16	3299649	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08		3299649	87055104	43	6863											
IL21R	50615	broad.mit.edu	37	chr16	27460197	27460197	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acggctacccagccctggacCtggatgctggcctggagccc	13	16	0	0			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr16:27460197C>A	uc002doq.1	+	9	1443	c.1210C>A	c.(1210-1212)CTG>ATG	p.L404M	IL21R_uc002dor.1_Missense_Mutation_p.L404M|IL21R_uc002dos.1_Missense_Mutation_p.L404M|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	404	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						AGCCCTGGACCTGGATGCTGG	0.632			T	BCL6	NHL								A	27460197	A	A	27460197	3	1	100	1	0	0	0	0	1	0	0	0	7671	680	24	5	1240	5	IL21R	16	27460197	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08	24160548	27460197	62894556	44	6864											
CLEC10A	10462	broad.mit.edu	37	chr17	6978469	6978469	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttccacctgccgtctggatgGaagtgagcacagtcctcgcc	11	14	1	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr17:6978469G>A	uc002gek.2	-	9	1158	c.855C>T	c.(853-855)TTC>TTT	p.F285F	CLEC10A_uc002gej.2_Silent_p.F261F|CLEC10A_uc002gel.2_Silent_p.F258F|CLEC10A_uc010clv.1_3'UTR	NM_182906	NP_878910	Q8IUN9	CLC10_HUMAN	C-type lectin, superfamily member 14 isoform 1	285	C-type lectin.|Extracellular (Potential).				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding				0						CGTCTGGATGGAAGTGAGCAC	0.627													A	6978469	A	A	6978469	2	1	100	1	0	0	0	0	0	0	0	1	3495	1165	41	3		3	CLEC10A	17	6978469	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08		6978469	74216741	45	6865											
DNAH2	146754	broad.mit.edu	37	chr17	7721011	7721011	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccactgagaatggcatcatcGtcacccgaggcaacaggtga	11	12	2	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr17:7721011G>A	uc002giu.1	+	65	10167	c.10153G>A	c.(10153-10155)GTC>ATC	p.V3385I	DNAH2_uc010cnm.1_Missense_Mutation_p.V323I	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3385	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGGCATCATCGTCACCCGAGG	0.597													A	7721011	A	A	7721011	3	1	100	1	0	0	0	0	1	0	0	0	4602	1145	40	1	10411	1	DNAH2	17	7721011	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08	742542	7721011	73474199	46	6866											
MYO15A	51168	broad.mit.edu	37	chr17	18058720	18058720	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggccaggaggccggcggGcagctgcgggtcctgcgtgc	21	12	0	0			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr17:18058720G>A	uc010vxh.1	+	46	8771	c.8433G>A	c.(8431-8433)GGG>GGA	p.G2811G	MYO15A_uc010vxi.1_Silent_p.G75G|MYO15A_uc010vxj.1_Silent_p.G10G|MYO15A_uc010vxk.1_Intron|MYO15A_uc010vxl.1_5'Flank|MYO15A_uc002gsl.2_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2811	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					AGGCCGGCGGGCAGCTGCGGG	0.637													A	18058720	A	A	18058720	2	1	100	1	0	0	0	0	0	0	0	1	10063	1190	42	3		3	MYO15A	17	18058720	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08	10337709	18058720	63136490	47	6867											
RNF213	57674	broad.mit.edu	37	chr17	78349658	78349658	+	Frame_Shift_Del	DEL	C	-	-													tcccacaatgcaagcctccaCcccacgccagaggtgagtaa							TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr17:78349658delC	uc002jyh.1	+	26	7615	c.7392delC	c.(7390-7392)CACfs	p.H2464fs	uc002jyi.1_Intron|RNF213_uc010dhw.1_Frame_Shift_Del_p.H846fs	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CAAGCCTCCACCCCACGCCAG	0.473													-	78349658	-	-	78349658	7	5	100	1	0	1	0	1	0	0	0	0	13477	506	18	0	13690	0	RNF213	17	78349658	Frame_Shift_Del	DEL	C	TCGA-06-6390-01A-11D-1696-08	60290938	78349658	2845552	48	6868											
C18orf55	29090	broad.mit.edu	37	chr18	71825425	71825425	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ggttcactgaatatgtaaaaGatgggctgaaacacacgtgt	11	6	1	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr18:71825425G>C	uc010dqr.1	+	5	854	c.556G>C	c.(556-558)GAT>CAT	p.D186H		NM_014177	NP_054896	Q9BVV7	TI21L_HUMAN	hypothetical protein LOC29090 precursor	186					protein transport|transmembrane transport	integral to membrane|mitochondrial membrane					0		Esophageal squamous(42;0.0746)|Prostate(75;0.157)|Melanoma(33;0.211)				ATATGTAAAAGATGGGCTGAA	0.448													C	71825425	C	C	71825425	3	2	100	1	0	0	0	0	1	0	0	0	1905	942	33	5	574	5	C18orf55	18	71825425	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08		71825425	6251823	49	6869											
POLRMT	5442	broad.mit.edu	37	chr19	629657	629657	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gcgaggggcagctggtcagtGagcaggcagcacttgaagaa	17	8	1	3			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr19:629657G>A	uc002lpf.1	-	3	761	c.705C>T	c.(703-705)CTC>CTT	p.L235L		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	235					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGTCAGTGAGCAGGCAGC	0.662													A	629657	A	A	629657	2	1	100	1	0	0	0	0	0	0	0	1	12238	1277	45	3		3	POLRMT	19	629657	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08		629657	58499326	50	6870											
MUC16	94025	broad.mit.edu	37	chr19	9056794	9056794	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggaatttcagtatactgtgAggctggaggccagtctgggg	16	6	2	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr19:9056794A>G	uc002mkp.2	-	3	30856	c.30652T>C	c.(30652-30654)TCA>CCA	p.S10218P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10220	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTATACTGTGAGGCTGGAGGC	0.463													G	9056794	G	G	9056794	3	3	100	1	0	0	0	0	1	0	0	0	9973	304	11	4	13199	4	MUC16	19	9056794	Missense_Mutation	SNP	A	TCGA-06-6390-01A-11D-1696-08	8427137	9056794	50072189	51	6871											
EPS15L1	58513	broad.mit.edu	37	chr19	16528878	16528878	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agctaacgcgaattggtcttTgcttaacttccccgtttgcc	8	12	1	0			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr19:16528878T>C	uc002ndz.1	-	11	994	c.988A>G	c.(988-990)AAA>GAA	p.K330E	EPS15L1_uc002ndx.2_Missense_Mutation_p.K330E|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.K220E|EPS15L1_uc010xpf.1_Missense_Mutation_p.K233E|EPS15L1_uc002nea.1_Missense_Mutation_p.K330E|EPS15L1_uc010eah.1_Missense_Mutation_p.K330E|EPS15L1_uc002neb.1_Missense_Mutation_p.K176E|EPS15L1_uc002nec.1_Missense_Mutation_p.K330E	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	330	EH 3.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						AATTGGTCTTTGCTTAACTTC	0.547											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	16528878	C	C	16528878	3	2	100	1	0	0	0	0	1	0	0	0	5193	1821	63	4	1658	4	EPS15L1	19	16528878	Missense_Mutation	SNP	T	TCGA-06-6390-01A-11D-1696-08	7472084	16528878	42600105	52	6872											
USHBP1	83878	broad.mit.edu	37	chr19	17362437	17362437	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctcggcactctgagaccGtctggctcgccccttctgag	11	16	3	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr19:17362437G>A	uc002nfs.1	-	12	1989	c.1876C>T	c.(1876-1878)CGG>TGG	p.R626W	USHBP1_uc002nfr.1_Missense_Mutation_p.R252W|USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Missense_Mutation_p.R562W	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	626	Potential.						PDZ domain binding			ovary(1)	1						CTCTGAGACCGTCTGGCTCGC	0.607													A	17362437	A	A	17362437	3	1	100	1	0	0	0	0	1	0	0	0	17034	1144	40	1	243	1	USHBP1	19	17362437	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08	833559	17362437	41766546	53	6873											
MAG	4099	broad.mit.edu	37	chr19	35786610	35786610	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctgccgctttgacttcccGgatgagctgcggcccgctgt	12	16	0	2			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr19:35786610G>A	uc002nyy.1	+	4	290	c.141G>A	c.(139-141)CCG>CCA	p.P47P	MAG_uc002nyx.1_Silent_p.P47P|MAG_uc010eds.1_Silent_p.P22P|MAG_uc002nyz.1_Silent_p.P47P	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	47	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTGACTTCCCGGATGAGCTGC	0.642													A	35786610	A	A	35786610	2	1	100	1	0	0	0	0	0	0	0	1	9162	1103	39	2		2	MAG	19	35786610	Silent	SNP	G	TCGA-06-6390-01A-11D-1696-08	18424173	35786610	23342373	54	6874											
PRDM15	63977	broad.mit.edu	37	chr21	43246405	43246405	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcctctcgcttcactcgccGcactcctgaaattgccaacc	6	18	2	1	rs139958739	by1000genomes	TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr21:43246405G>A	uc002yzq.1	-	20	2749	c.2638C>T	c.(2638-2640)CGG>TGG	p.R880W	PRDM15_uc002yzo.2_Missense_Mutation_p.R551W|PRDM15_uc002yzp.2_Missense_Mutation_p.R571W|PRDM15_uc002yzr.1_Missense_Mutation_p.R571W	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	880					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCACTCGCCGCACTCCTGAA	0.577													A	43246405	A	A	43246405	3	1	100	1	0	0	0	0	1	0	0	0	12456	1086	38	1	1933	1	PRDM15	21	43246405	Missense_Mutation	SNP	G	TCGA-06-6390-01A-11D-1696-08		43246405	4883490	55	6875											
PIWIL3	440822	broad.mit.edu	37	chr22	25155854	25155854	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttgagactgtgctcctcCtcctgctcctcctcttgctg	7	17	1	1			TCGA-06-6390-01A-11D-1696-08	TCGA-06-6390-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	f04b6bde-63e0-41c9-89f7-07673f9de0f6	6c5cfe7c-84fa-4bfb-84f8-eebe7cb9bc0e	g.chr22:25155854C>T	uc003abd.1	-	3	622	c.205G>A	c.(205-207)GGA>AGA	p.G69R	PIWIL3_uc011ajx.1_5'UTR|PIWIL3_uc011ajy.1_5'UTR|PIWIL3_uc010gut.1_Missense_Mutation_p.G69R	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	69					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						TGTGCTCCTCCTCCTGCTCCT	0.582													T	25155854	T	T	25155854	3	4	100	1	0	0	0	0	1	0	0	0	11959	690	24	3	2519	3	PIWIL3	22	25155854	Missense_Mutation	SNP	C	TCGA-06-6390-01A-11D-1696-08		25155854	26148712	56	6876											
HTR1D	3352	broad.mit.edu	37	chr1	23520158	23520158	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgttcaccagacagtccgaCatctcctcctgggccttggc	10	15	2	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr1:23520158C>T	uc001bgn.2	-	1	1065	c.555G>A	c.(553-555)ATG>ATA	p.M185I		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	185	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	GACAGTCCGACATCTCCTCCT	0.592													T	23520158	T	T	23520158	3	4	101	1	0	0	0	0	1	0	0	0	7438	478	17	3	582	3	HTR1D	1	23520158	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08		23520158	225730463	1	6877											
MTF1	4520	broad.mit.edu	37	chr1	38305766	38305766	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggtgagtcttctggtgggttCgcaggttgcctgctgtgctg	17	8	2	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr1:38305766C>T	uc001cce.1	-	3	614	c.473G>A	c.(472-474)CGA>CAA	p.R158Q	MTF1_uc009vvj.1_5'UTR	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	158	C2H2-type 1.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CTGGTGGGTTCGCAGGTTGCC	0.527													T	38305766	T	T	38305766	3	4	101	1	0	0	0	0	1	0	0	0	9922	884	31	2	1824	2	MTF1	1	38305766	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	14785608	38305766	210944855	2	6878											
IL12RB2	3595	broad.mit.edu	37	chr1	67861543	67861543	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacccagcctgtccctggaCggtgctcccagcaggtgacc	11	16	0	1	rs141507006		TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr1:67861543C>T	uc001ddu.2	+	16	3000	c.2360C>T	c.(2359-2361)ACG>ATG	p.T787M	IL12RB2_uc010oqi.1_3'UTR|IL12RB2_uc010oqj.1_3'UTR|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.T701M|IL12RB2_uc010oqm.1_3'UTR|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	787	Cytoplasmic (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						TGTCCCTGGACGGTGCTCCCA	0.582													T	67861543	T	T	67861543	3	4	101	1	0	0	0	0	1	0	0	0	7627	536	19	1	2418	1	IL12RB2	1	67861543	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	29555777	67861543	181389078	3	6879											
LRRC8D	55144	broad.mit.edu	37	chr1	90400304	90400304	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cctgcctgggtgtatttgctCaaaaaccttcgagagttgta	10	9	1	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr1:90400304C>G	uc001dnm.2	+	3	2102	c.1677C>G	c.(1675-1677)CTC>CTG	p.L559L	LRRC8D_uc001dnn.2_Silent_p.L559L	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	559	LRR 2.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		TGTATTTGCTCAAAAACCTTC	0.418													G	90400304	G	G	90400304	2	3	101	1	0	0	0	0	0	0	0	1	9024	813	29	5		5	LRRC8D	1	90400304	Silent	SNP	C	TCGA-06-6391-01A-11D-1696-08	22538761	90400304	158850317	4	6880											
C1orf85	112770	broad.mit.edu	37	chr1	156264001	156264001	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aggcgagggggttgggctggTcggctggacctggaaaaggc	21	7	0	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr1:156264001T>A	uc001foh.2	-	4	619	c.606A>T	c.(604-606)CGA>CGT	p.R202R	C1orf85_uc001fof.3_5'Flank|C1orf85_uc001fog.1_Intron|C1orf85_uc001foi.2_Silent_p.R202R|C1orf85_uc009wrx.2_Silent_p.R135R|C1orf85_uc001foj.2_Silent_p.R116R	NM_144580	NP_653181	Q8WWB7	NCUG1_HUMAN	kidney predominant protein NCU-G1 precursor	202	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2	Hepatocellular(266;0.158)					GTTGGGCTGGTCGGCTGGACC	0.592													A	156264001	A	A	156264001	2	1	101	1	0	0	0	0	0	0	0	1	2062	1654	58	5		5	C1orf85	1	156264001	Silent	SNP	T	TCGA-06-6391-01A-11D-1696-08	65863697	156264001	92986620	5	6881											
NTRK1	4914	broad.mit.edu	37	chr1	156841494	156841494	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggaagaacgtgacgtgctGggcagagaacgatgtgggcc	17	8	0	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr1:156841494G>A	uc001fqh.1	+	7	853	c.797G>A	c.(796-798)TGG>TAG	p.W266*	NTRK1_uc001fqf.1_Nonsense_Mutation_p.W236*|NTRK1_uc009wsi.1_Intron|NTRK1_uc001fqi.1_Nonsense_Mutation_p.W266*|NTRK1_uc009wsk.1_Nonsense_Mutation_p.W266*	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	266	Ig-like C2-type 1.|Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GTGACGTGCTGGGCAGAGAAC	0.592			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			A	156841494	A	A	156841494	4	1	101	1	0	0	0	0	0	1	0	0	10706	1357	47	3	953	3	NTRK1	1	156841494	Nonsense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	577493	156841494	92409127	6	6882											
SIPA1L2	57568	broad.mit.edu	37	chr1	232574923	232574923	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cactgccggcggagatggtgGacgcgtagccatgcacagaa	15	11	0	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr1:232574923G>A	uc001hvg.2	-	13	4120	c.3962C>T	c.(3961-3963)TCC>TTC	p.S1321F	SIPA1L2_uc001hvf.2_Missense_Mutation_p.S395F	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1321	Ser-rich.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GGAGATGGTGGACGCGTAGCC	0.602													A	232574923	A	A	232574923	3	1	101	1	0	0	0	0	1	0	0	0	14330	1174	41	3	1242	3	SIPA1L2	1	232574923	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	75733429	232574923	16675698	7	6883											
APOB	338	broad.mit.edu	37	chr2	21229086	21229086	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcgttggagtgtggcttctcCagcaaaattttcttttactt	9	8	2	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr2:21229086C>G	uc002red.2	-	26	10782	c.10654G>C	c.(10654-10656)GGA>CGA	p.G3552R		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3552					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTGGCTTCTCCAGCAAAATTT	0.443													G	21229086	G	G	21229086	3	3	101	1	0	0	0	0	1	0	0	0	785	603	21	5	3053	5	APOB	2	21229086	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08		21229086	221970287	8	6884											
APOB	338	broad.mit.edu	37	chr2	21245793	21245793	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caacatgagcctccagacccGactcgtggaagaagttggtg	12	11	0	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr2:21245793G>A	uc002red.2	-	18	2854	c.2726C>T	c.(2725-2727)TCG>TTG	p.S909L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	909	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTCCAGACCCGACTCGTGGAA	0.498													A	21245793	A	A	21245793	3	1	101	1	0	0	0	0	1	0	0	0	785	1059	37	2	11013	2	APOB	2	21245793	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	16707	21245793	221953580	9	6885											
NEB	4703	broad.mit.edu	37	chr2	152476016	152476016	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaatgatgtcattctggtcGggcaggcagatccattcatg	12	8	3	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr2:152476016G>A	uc010fnx.2	-	69	10283	c.10092C>T	c.(10090-10092)CCC>CCT	p.P3364P		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3364	Nebulin 92.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATTCTGGTCGGGCAGGCAGA	0.483													A	152476016	A	A	152476016	2	1	101	1	0	0	0	0	0	0	0	1	10302	1103	39	2		2	NEB	2	152476016	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	131230223	152476016	90723357	10	6886											
ZNF142	7701	broad.mit.edu	37	chr2	219509392	219509392	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgttgggccctgcatggccCcttctggctcctggcttgca	13	14	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr2:219509392C>T	uc002vin.2	-	8	2283	c.1847G>A	c.(1846-1848)GGG>GAG	p.G616E	ZNF142_uc002vil.2_Missense_Mutation_p.G577E|ZNF142_uc010fvt.2_Missense_Mutation_p.G453E|ZNF142_uc002vim.2_Missense_Mutation_p.G453E	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CTGCATGGCCCCTTCTGGCTC	0.607													T	219509392	T	T	219509392	3	4	101	1	0	0	0	0	1	0	0	0	17728	623	22	3	3228	3	ZNF142	2	219509392	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	67033376	219509392	23689981	11	6887											
ASB18	401036	broad.mit.edu	37	chr2	237103656	237103656	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatgctgcaggcagcgtggGgtgagggccaaggcaaagag	19	7	0	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr2:237103656G>A	uc010znh.1	-	6	1260	c.1260C>T	c.(1258-1260)ACC>ACT	p.T420T		NM_212556	NP_997721	Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box-containing 18	420	SOCS box.				intracellular signal transduction					ovary(1)	1		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		GGCAGCGTGGGGTGAGGGCCA	0.557													A	237103656	A	A	237103656	2	1	101	1	0	0	0	0	0	0	0	1	1022	1219	43	3		3	ASB18	2	237103656	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	17594264	237103656	6095717	12	6888											
SCN10A	6336	broad.mit.edu	37	chr3	38743393	38743393	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccatttgtgaagtagtactGcctcaaagcgaacatcttca	8	10	3	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr3:38743393G>A	uc003ciq.2	-	26	4594	c.4594C>T	c.(4594-4596)CAG>TAG	p.Q1532*		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1532	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AAGTAGTACTGCCTCAAAGCG	0.483													A	38743393	A	A	38743393	4	1	101	1	0	0	0	0	0	1	0	0	13912	1328	46	3	1284	3	SCN10A	3	38743393	Nonsense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08		38743393	159279037	13	6889											
CCR5	1234	broad.mit.edu	37	chr3	46414869	46414869	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgggtggtggctgtgtttgCgtctctcccaggaatcatct	13	9	3	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr3:46414869C>T	uc003cpo.3	+	3	598	c.476C>T	c.(475-477)GCG>GTG	p.A159V	CCR5_uc010hjd.2_Missense_Mutation_p.A159V	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	159	Helical; Name=4; (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	GCTGTGTTTGCGTCTCTCCCA	0.468													T	46414869	T	T	46414869	3	4	101	1	0	0	0	0	1	0	0	0	2944	768	27	1	478	1	CCR5	3	46414869	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	7671476	46414869	151607561	14	6890											
SEMA3G	56920	broad.mit.edu	37	chr3	52469856	52469856	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggatgtccttgtaccaggcCttgggtggggtggaagccag	17	8	0	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr3:52469856C>T	uc003dea.1	-	16	2112	c.2112G>A	c.(2110-2112)AAG>AAA	p.K704K		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	704					multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		TGTACCAGGCCTTGGGTGGGG	0.642													T	52469856	T	T	52469856	2	4	101	1	0	0	0	0	0	0	0	1	14030	680	24	3		3	SEMA3G	3	52469856	Silent	SNP	C	TCGA-06-6391-01A-11D-1696-08	6054987	52469856	145552574	15	6891											
EAF2	55840	broad.mit.edu	37	chr3	121573665	121573665	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agcaacatcactgtaaaaaaAacaaggtatgtggtttaatg	8	5	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr3:121573665A>T	uc003een.2	+	3	432	c.333A>T	c.(331-333)AAA>AAT	p.K111N	EAF2_uc003eeo.2_Intron	NM_018456	NP_060926	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	111					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding				0				GBM - Glioblastoma multiforme(114;0.0972)		CTGTAAAAAAAACAAGGTATG	0.249													T	121573665	T	T	121573665	3	4	101	1	0	0	0	0	1	0	0	0	4876	11	1	5	343	5	EAF2	3	121573665	Missense_Mutation	SNP	A	TCGA-06-6391-01A-11D-1696-08	69103809	121573665	76448765	16	6892											
MBNL1	4154	broad.mit.edu	37	chr3	152163096	152163096	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcgagagtaccaacgtggcaAttgcaaccgaggagaaaatg	12	8	0	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr3:152163096A>T	uc003ezm.2	+	4	1364	c.575A>T	c.(574-576)AAT>ATT	p.N192I	MBNL1_uc003ezh.2_Missense_Mutation_p.N192I|MBNL1_uc003ezi.2_Missense_Mutation_p.N192I|MBNL1_uc003ezj.2_Missense_Mutation_p.N135I|MBNL1_uc003ezl.2_Missense_Mutation_p.N192I|MBNL1_uc003ezp.2_Missense_Mutation_p.N192I|MBNL1_uc003ezn.2_Missense_Mutation_p.N124I|MBNL1_uc003ezo.2_Missense_Mutation_p.N124I|MBNL1_uc010hvp.2_Missense_Mutation_p.N100I	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	muscleblind-like 1 isoform c	192	C3H1-type 3.				embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CAACGTGGCAATTGCAACCGA	0.403													T	152163096	T	T	152163096	3	4	101	1	0	0	0	0	1	0	0	0	9353	101	4	5	589	5	MBNL1	3	152163096	Missense_Mutation	SNP	A	TCGA-06-6391-01A-11D-1696-08	30589431	152163096	45859334	17	6893											
PIK3CA	5290	broad.mit.edu	37	chr3	178916876	178916876	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attttttgatgaaacaagacGactttgtgaccttcggcttt	8	7	0	4	rs121913287		TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr3:178916876G>A	uc003fjk.2	+	2	420	c.263G>A	c.(262-264)CGA>CAA	p.R88Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	88	PI3K-ABD.		R -> Q (in cancer; may disrupt the interaction between the PI3K-ABD domain and the N-terminal lobe of PI3K/PI4K kinase domain possibly affecting the conformation of the kinase domain).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R88Q(26)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAACAAGACGACTTTGTGAC	0.363	R88Q(SKUT1_SOFT_TISSUE)|R88Q(JHUEM1_ENDOMETRIUM)|R88Q(SNGM_ENDOMETRIUM)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178916876	A	A	178916876	3	1	101	1	0	0	0	0	1	0	0	0	11913	1058	37	2	265	2	PIK3CA	3	178916876	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	26753780	178916876	19105554	18	6894											
TXK	7294	broad.mit.edu	37	chr4	48106929	48106929	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgaattacctcttgtctcaAtagatgttctgcctgatttc	6	9	3	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr4:48106929A>G	uc003gxx.3	-	6	576	c.490T>C	c.(490-492)TTG>CTG	p.L164L	TXK_uc003gxy.1_Silent_p.L164L	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	164	SH2.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TCTTGTCTCAATAGATGTTCT	0.244													G	48106929	G	G	48106929	2	3	101	1	0	0	0	0	0	0	0	1	16783	98	4	4		4	TXK	4	48106929	Silent	SNP	A	TCGA-06-6391-01A-11D-1696-08		48106929	143047347	19	6895											
CCDC158	339965	broad.mit.edu	37	chr4	77283442	77283442	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctggcctcaagctcccggatCtttgcatcttttttatcttt	6	12	4	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr4:77283442C>A	uc003hkb.3	-	12	2010	c.1857G>T	c.(1855-1857)AAG>AAT	p.K619N		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	619	Potential.									skin(3)|ovary(2)|pancreas(1)	6						GCTCCCGGATCTTTGCATCTT	0.393													A	77283442	A	A	77283442	3	1	101	1	0	0	0	0	1	0	0	0	2790	912	32	5	1536	5	CCDC158	4	77283442	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	29176513	77283442	113870834	20	6896											
DNAH5	1767	broad.mit.edu	37	chr5	13871097	13871097	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttgtctcagcagtcagggCgaacttcaagtcagctgtaa	10	10	4	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr5:13871097C>T	uc003jfd.2	-	24	3655	c.3613G>A	c.(3613-3615)GCC>ACC	p.A1205T		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1205	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCAGTCAGGGCGAACTTCAAG	0.403									Kartagener_syndrome				T	13871097	T	T	13871097	3	4	101	1	0	0	0	0	1	0	0	0	4604	768	27	1	10485	1	DNAH5	5	13871097	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08		13871097	167044163	21	6897											
HEATR7B2	133558	broad.mit.edu	37	chr5	41051145	41051145	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggcttgtttctcggacagaTtcctcttccttttcattctc	6	12	4	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr5:41051145T>C	uc003jmj.3	-	13	1768	c.1278A>G	c.(1276-1278)GAA>GAG	p.E426E	HEATR7B2_uc003jmi.3_5'UTR	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	426	HEAT 5.						binding			ovary(6)|central_nervous_system(2)	8						CTCGGACAGATTCCTCTTCCT	0.423													C	41051145	C	C	41051145	2	2	101	1	0	0	0	0	0	0	0	1	7035	1490	52	4		4	HEATR7B2	5	41051145	Silent	SNP	T	TCGA-06-6391-01A-11D-1696-08	27180048	41051145	139864115	22	6898											
PCDHA3	56145	broad.mit.edu	37	chr5	140181903	140181903	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtcatcgctctgatcagcgTgtccgaccgcgactcaggag	12	13	4	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr5:140181903T>C	uc003lhf.2	+	1	1121	c.1121T>C	c.(1120-1122)GTG>GCG	p.V374A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.V374A	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	374	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGATCAGCGTGTCCGACCGC	0.483													C	140181903	C	C	140181903	3	2	101	1	0	0	0	0	1	0	0	0	11525	1696	59	4	1123	4	PCDHA3	5	140181903	Missense_Mutation	SNP	T	TCGA-06-6391-01A-11D-1696-08	99130758	140181903	40733357	23	6899											
GLRA1	2741	broad.mit.edu	37	chr5	151230995	151230995	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggagctctgggtggtcatggTgagcacagtggtgatgccta	17	7	2	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr5:151230995T>A	uc003lut.2	-	7	1155	c.868A>T	c.(868-870)ACC>TCC	p.T290S	GLRA1_uc003lur.2_Missense_Mutation_p.T290S|GLRA1_uc003lus.2_Missense_Mutation_p.T207S	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	290	Helical; (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GTGGTCATGGTGAGCACAGTG	0.547													A	151230995	A	A	151230995	3	1	101	1	0	0	0	0	1	0	0	0	6454	1696	59	5	517	5	GLRA1	5	151230995	Missense_Mutation	SNP	T	TCGA-06-6391-01A-11D-1696-08	11049092	151230995	29684265	24	6900											
ZNF165	7718	broad.mit.edu	37	chr6	28056507	28056507	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtaaagagacaatgggaaaaAgaatcaggggagtctcagag	14	4	2	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr6:28056507A>G	uc003nkg.2	+	5	1801	c.717A>G	c.(715-717)AAA>AAG	p.K239K	ZNF165_uc003nkh.2_Silent_p.K239K|ZNF165_uc003nki.3_Silent_p.K239K|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	239					viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AATGGGAAAAAGAATCAGGGG	0.433													G	28056507	G	G	28056507	2	3	101	1	0	0	0	0	0	0	0	1	17737	69	3	4		4	ZNF165	6	28056507	Silent	SNP	A	TCGA-06-6391-01A-11D-1696-08		28056507	143058560	25	6901											
SLC26A8	116369	broad.mit.edu	37	chr6	35922972	35922972	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtgaatccacgtagtgtaccAtggagaaatccaggatgatg	12	7	0	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr6:35922972A>T	uc003olm.2	-	17	2300	c.2189T>A	c.(2188-2190)ATG>AAG	p.M730K	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.M312K|SLC26A8_uc003oln.2_Missense_Mutation_p.M730K|SLC26A8_uc003oll.2_Missense_Mutation_p.M625K	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	730	Interaction with RACGAP1.|STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						GTAGTGTACCATGGAGAAATC	0.547													T	35922972	T	T	35922972	3	4	101	1	0	0	0	0	1	0	0	0	14523	217	8	5	739	5	SLC26A8	6	35922972	Missense_Mutation	SNP	A	TCGA-06-6391-01A-11D-1696-08	7866465	35922972	135192095	26	6902											
EPM2A	7957	broad.mit.edu	37	chr6	145948736	145948736	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacagccgcggtggagcggCccaccccagcgttgcagtgc	15	15	0	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr6:145948736C>T	uc003qkw.2	-	4	1169	c.812G>A	c.(811-813)GGC>GAC	p.G271D	EPM2A_uc003qkv.2_Missense_Mutation_p.G271D|EPM2A_uc010khr.2_Silent_p.G190G|EPM2A_uc003qkx.2_Missense_Mutation_p.G133D|EPM2A_uc003qku.2_Missense_Mutation_p.G117D	NM_005670	NP_005661	O95278	EPM2A_HUMAN	laforin isoform a	271	Tyrosine-protein phosphatase.				glycogen metabolic process	cytosol|endoplasmic reticulum|nucleus|plasma membrane|polysome	carbohydrate binding|identical protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Ovarian(120;0.162)		OV - Ovarian serous cystadenocarcinoma(155;3.38e-07)|GBM - Glioblastoma multiforme(68;0.0203)		GGTGGAGCGGCCCACCCCAGC	0.632													T	145948736	T	T	145948736	3	4	101	1	0	0	0	0	1	0	0	0	5183	739	26	3	221	3	EPM2A	6	145948736	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	110025764	145948736	25166331	27	6903											
C7orf10	79783	broad.mit.edu	37	chr7	40899925	40899925	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cctttggcaggcccagctgtGagatacagtaagttcaagat	11	9	1	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr7:40899925G>C	uc003thn.1	+	14	1209	c.1164G>C	c.(1162-1164)GTG>GTC	p.V388V	C7orf10_uc003thm.1_Silent_p.V384V|C7orf10_uc003tho.1_Silent_p.V340V|C7orf10_uc003thp.1_RNA	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	395							transferase activity			ovary(2)	2						GCCCAGCTGTGAGATACAGTA	0.527													C	40899925	C	C	40899925	2	2	101	1	0	0	0	0	0	0	0	1	2376	1277	45	5		5	C7orf10	7	40899925	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08		40899925	118238738	28	6904			1	24		2	2	26	G		6.298915e-05
C7orf10	79783	broad.mit.edu	37	chr7	40899950	40899950	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acagtaagttcaagatgtcaGaggccaggccgcccccgctg	12	13	2	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr7:40899950G>C	uc003thn.1	+	14	1234	c.1189G>C	c.(1189-1191)GAG>CAG	p.E397Q	C7orf10_uc003thm.1_Missense_Mutation_p.E393Q|C7orf10_uc003tho.1_Missense_Mutation_p.E349Q|C7orf10_uc003thp.1_RNA	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	404							transferase activity			ovary(2)	2						CAAGATGTCAGAGGCCAGGCC	0.552													C	40899950	C	C	40899950	3	2	101	1	0	0	0	0	1	0	0	0	2376	943	33	5	1235	5	C7orf10	7	40899950	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	25	40899950	118238713	29	6905			1	24		2	2	26	G		6.298915e-05
STEAP4	79689	broad.mit.edu	37	chr7	87912074	87912074	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccaagccaagctgctttcggCaaagcatccagtggtcaagc	10	13	1	0	rs79363691		TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr7:87912074C>A	uc003ujs.2	-	3	971	c.866G>T	c.(865-867)TGC>TTC	p.C289F	STEAP4_uc010lek.2_Intron|STEAP4_uc003ujt.2_Missense_Mutation_p.C289F	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	289	Ferric oxidoreductase.				fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					CTGCTTTCGGCAAAGCATCCA	0.478													A	87912074	A	A	87912074	3	1	101	1	0	0	0	0	1	0	0	0	15279	710	25	5	525	5	STEAP4	7	87912074	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	47012124	87912074	71226589	30	6906											
EZH2	2146	broad.mit.edu	37	chr7	148506237	148506237	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctatcctgtgatcaccgttAaccatcataactgcaaagag	6	12	2	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr7:148506237A>T	uc003wfd.1	-	19	2272	c.2106T>A	c.(2104-2106)GTT>GTA	p.V702V	EZH2_uc011kug.1_Silent_p.V651V|EZH2_uc003wfb.1_Silent_p.V707V|EZH2_uc003wfc.1_Silent_p.V663V|EZH2_uc011kuh.1_Silent_p.V693V	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	702	SET.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			GATCACCGTTAACCATCATAA	0.443			Mis		DLBCL								T	148506237	T	T	148506237	2	4	101	1	0	0	0	0	0	0	0	1	5334	349	13	5		5	EZH2	7	148506237	Silent	SNP	A	TCGA-06-6391-01A-11D-1696-08	60594163	148506237	10632426	31	6907											
ZFHX4	79776	broad.mit.edu	37	chr8	77766549	77766549	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttatcggaagacctccctcGgcctctcaaacaccggtccc	7	18	1	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr8:77766549G>A	uc003yav.2	+	10	7644	c.7257G>A	c.(7255-7257)TCG>TCA	p.S2419S	ZFHX4_uc003yau.1_Silent_p.S2464S|ZFHX4_uc003yaw.1_Silent_p.S2419S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2419	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GACCTCCCTCGGCCTCTCAAA	0.423										HNSCC(33;0.089)			A	77766549	A	A	77766549	2	1	101	1	0	0	0	0	0	0	0	1	17632	1103	39	2		2	ZFHX4	8	77766549	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08		77766549	68597473	32	6908											
IARS	3376	broad.mit.edu	37	chr9	95050515	95050515	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtacccgcaagtatatgtcCatagtgaggcagtccagttg	11	9	0	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr9:95050515C>T	uc004art.1	-	3	426	c.169G>A	c.(169-171)GGA>AGA	p.G57R	IARS_uc004ars.1_5'UTR|IARS_uc004aru.3_Missense_Mutation_p.G57R|IARS_uc010mqr.2_Intron|IARS_uc010mqt.2_Missense_Mutation_p.M12I	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	57	HIGH region.				isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	AGTATATGTCCATAGTGAGGC	0.368													T	95050515	T	T	95050515	3	4	101	1	0	0	0	0	1	0	0	0	7473	603	21	3	3747	3	IARS	9	95050515	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08		95050515	46162916	33	6909											
DNM1	1759	broad.mit.edu	37	chr9	130965824	130965824	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gccttctctgccatcggccaGaacgcggacctcgacctgcc	10	18	1	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr9:130965824G>A	uc011mau.1	+	1	162	c.75G>A	c.(73-75)CAG>CAA	p.Q25Q	CIZ1_uc004btw.2_Intron|CIZ1_uc004btv.2_Intron|DNM1_uc010mxr.2_Silent_p.Q25Q|DNM1_uc011mat.1_Silent_p.Q25Q	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	25					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						CCATCGGCCAGAACGCGGACC	0.692													A	130965824	A	A	130965824	2	1	101	1	0	0	0	0	0	0	0	1	4670	933	33	3		3	DNM1	9	130965824	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	35915309	130965824	10247607	34	6910											
SORBS1	10580	broad.mit.edu	37	chr10	97096883	97096883	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	agtgttatagatagaagcctCtggcagaggaggcaagggtg	16	5	1	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr10:97096883C>G	uc001kkp.2	-	28	3079	c.3034G>C	c.(3034-3036)GAG>CAG	p.E1012Q	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.E966Q|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1012					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		ATAGAAGCCTCTGGCAGAGGA	0.607													G	97096883	G	G	97096883	3	3	101	1	0	0	0	0	1	0	0	0	14927	922	32	5	924	5	SORBS1	10	97096883	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08		97096883	38437864	35	6911											
OR10Q1	219960	broad.mit.edu	37	chr11	57996044	57996044	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagaagaacatttgggcccCacatccagccaacgaaatgg	9	11	0	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr11:57996044C>T	uc010rkd.1	-	1	304	c.304G>A	c.(304-306)GGG>AGG	p.G102R		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	102	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				ATTTGGGCCCCACATCCAGCC	0.547													T	57996044	T	T	57996044	3	4	101	1	0	0	0	0	1	0	0	0	10916	594	21	3	659	3	OR10Q1	11	57996044	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08		57996044	77010472	36	6912											
GAB2	9846	broad.mit.edu	37	chr11	77934481	77934481	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgatcaggtttgaggttgCggttgacagggggtggctga	18	6	1	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr11:77934481C>T	uc001ozh.2	-	6	1544	c.1544G>A	c.(1543-1545)CGC>CAC	p.R515H	GAB2_uc001ozg.2_Missense_Mutation_p.R477H	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	515	SH3-binding.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TTTGAGGTTGCGGTTGACAGG	0.547													T	77934481	T	T	77934481	3	4	101	1	0	0	0	0	1	0	0	0	6149	768	27	1	506	1	GAB2	11	77934481	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	19938437	77934481	57072035	37	6913											
PDGFD	80310	broad.mit.edu	37	chr11	103797801	103797801	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcttatattgaccgagtaatTcctgggagtgcaactgtaac	9	8	1	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr11:103797801T>C	uc001phq.2	-	6	1198	c.826A>G	c.(826-828)AAT>GAT	p.N276D	PDGFD_uc001php.2_Missense_Mutation_p.N270D	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	276					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		ACCGAGTAATTCCTGGGAGTG	0.478													C	103797801	C	C	103797801	3	2	101	1	0	0	0	0	1	0	0	0	11660	1783	62	4	294	4	PDGFD	11	103797801	Missense_Mutation	SNP	T	TCGA-06-6391-01A-11D-1696-08	25863320	103797801	31208715	38	6914											
CD163	9332	broad.mit.edu	37	chr12	7639374	7639374	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctctactctcccagcacagcGacctcctccatttaccaggc	5	19	2	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:7639374G>A	uc001qsz.3	-	10	2307	c.2179C>T	c.(2179-2181)CGC>TGC	p.R727C	CD163_uc001qta.3_Missense_Mutation_p.R727C|CD163_uc009zfw.2_Missense_Mutation_p.R760C	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	727	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CCAGCACAGCGACCTCCTCCA	0.458													A	7639374	A	A	7639374	3	1	101	1	0	0	0	0	1	0	0	0	2967	1058	37	2	1319	2	CD163	12	7639374	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08		7639374	126212521	39	6915											
GUCY2C	2984	broad.mit.edu	37	chr12	14840978	14840978	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccgaatacatgaaagtagcGttcacagtcacatttaggcc	8	10	2	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:14840978G>A	uc001rcd.2	-	2	374	c.237C>T	c.(235-237)AAC>AAT	p.N79N	GUCY2C_uc009zhz.2_Silent_p.N79N	NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	79	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TGAAAGTAGCGTTCACAGTCA	0.433													A	14840978	A	A	14840978	2	1	101	1	0	0	0	0	0	0	0	1	6896	1136	40	1		1	GUCY2C	12	14840978	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	7201604	14840978	119010917	40	6916											
RERGL	79785	broad.mit.edu	37	chr12	18237578	18237578	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccagtgaagctcacttgtgaGggagaattttgctttctgtg	12	7	2	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:18237578G>T	uc001rdq.2	-	5	402	c.208C>A	c.(208-210)CTC>ATC	p.L70I	RERGL_uc001rdr.2_Missense_Mutation_p.L69I	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	70	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						TCACTTGTGAGGGAGAATTTT	0.383													T	18237578	T	T	18237578	3	4	101	1	0	0	0	0	1	0	0	0	13233	1000	35	5	417	5	RERGL	12	18237578	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	3396600	18237578	115614317	41	6917											
C12orf40	283461	broad.mit.edu	37	chr12	40114778	40114778	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accagttctcagtgaaaaatAatacagatcagtttccacag	6	9	2	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:40114778A>G	uc001rmc.2	+	13	1851	c.1684A>G	c.(1684-1686)AAT>GAT	p.N562D	C12orf40_uc009zjv.1_Intron	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	562										ovary(6)	6						AGTGAAAAATAATACAGATCA	0.393													G	40114778	G	G	40114778	3	3	101	1	0	0	0	0	1	0	0	0	1686	362	13	4	1734	4	C12orf40	12	40114778	Missense_Mutation	SNP	A	TCGA-06-6391-01A-11D-1696-08	21877200	40114778	93737117	42	6918			2	25		3	3	206	A		1.327039e-07
C12orf40	283461	broad.mit.edu	37	chr12	40114932	40114932	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaattagatgttgccatacAgtgtgatctaatttcaaaat	6	5	2	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:40114932A>G	uc001rmc.2	+	13	2005	c.1838A>G	c.(1837-1839)CAG>CGG	p.Q613R	C12orf40_uc009zjv.1_Intron	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	613										ovary(6)	6						GTTGCCATACAGTGTGATCTA	0.408													G	40114932	G	G	40114932	3	3	101	1	0	0	0	0	1	0	0	0	1686	188	7	4	1888	4	C12orf40	12	40114932	Missense_Mutation	SNP	A	TCGA-06-6391-01A-11D-1696-08	154	40114932	93736963	43	6919			2	25		3	3	206	A		1.327039e-07
C12orf40	283461	broad.mit.edu	37	chr12	40114983	40114983	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagtgatgtttctctttgcaAccttgaaaggtgcagtggaa	11	6	1	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:40114983A>C	uc001rmc.2	+	13	2056	c.1889A>C	c.(1888-1890)AAC>ACC	p.N630T	C12orf40_uc009zjv.1_Intron	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	630										ovary(6)	6						TCTCTTTGCAACCTTGAAAGG	0.363													C	40114983	C	C	40114983	3	2	101	1	0	0	0	0	1	0	0	0	1686	43	2	5	1939	5	C12orf40	12	40114983	Missense_Mutation	SNP	A	TCGA-06-6391-01A-11D-1696-08	51	40114983	93736912	44	6920			2	25		3	3	206	A		1.327039e-07
SLC2A13	114134	broad.mit.edu	37	chr12	40153845	40153845	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaattattccacatcagaagCatcattgtcagaaagatgat	6	7	3	4			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:40153845C>T	uc010skm.1	-	10	1981	c.1930G>A	c.(1930-1932)GCT>ACT	p.A644T	C12orf40_uc009zjv.1_Intron	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	644	Cytoplasmic (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				ACATCAGAAGCATCATTGTCA	0.383										HNSCC(50;0.14)			T	40153845	T	T	40153845	3	4	101	1	0	0	0	0	1	0	0	0	14542	710	25	3	20	3	SLC2A13	12	40153845	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	38862	40153845	93698050	45	6921											
R3HDM2	22864	broad.mit.edu	37	chr12	57677642	57677642	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttcccgcactgccgcctttaCtgctgccgatgctgtcacct	8	17	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:57677642C>G	uc009zpm.1	-	11	1129	c.1094G>C	c.(1093-1095)AGT>ACT	p.S365T	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Missense_Mutation_p.S26T|R3HDM2_uc001snr.2_Missense_Mutation_p.S92T|R3HDM2_uc001sns.2_Missense_Mutation_p.S365T|R3HDM2_uc001snt.2_Missense_Mutation_p.S379T	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	365	Ser-rich.					nucleus	nucleic acid binding			ovary(2)	2						GCCGCCTTTACTGCTGCCGAT	0.532													G	57677642	G	G	57677642	3	3	101	1	0	0	0	0	1	0	0	0	12888	565	20	5	1884	5	R3HDM2	12	57677642	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	17523797	57677642	76174253	46	6922											
PTPRR	5801	broad.mit.edu	37	chr12	71286523	71286523	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagatcttgaccatccatgGccagcagattgagagacggg	12	10	1	5			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:71286523G>A	uc001swi.1	-	2	709	c.293C>T	c.(292-294)GCC>GTC	p.A98V		NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	98	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		ACCATCCATGGCCAGCAGATT	0.458													A	71286523	A	A	71286523	3	1	101	1	0	0	0	0	1	0	0	0	12810	1203	42	3	1732	3	PTPRR	12	71286523	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	13608881	71286523	62565372	47	6923											
MYF5	4617	broad.mit.edu	37	chr12	81110965	81110965	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgagtggctgccttcggagcGcacaaagcagagctgcaggg	16	11	0	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:81110965G>A	uc001szg.2	+	1	258	c.123G>A	c.(121-123)GCG>GCA	p.A41A		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	41					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CCTTCGGAGCGCACAAAGCAG	0.617													A	81110965	A	A	81110965	2	1	101	1	0	0	0	0	0	0	0	1	10027	1074	38	1		1	MYF5	12	81110965	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	9824442	81110965	52740930	48	6924											
ALX1	8092	broad.mit.edu	37	chr12	85695019	85695019	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cgtgacacttcctcctgtatGacaccttattctcactcgcc	5	16	1	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:85695019G>A	uc001tae.3	+	4	751	c.747G>A	c.(745-747)ATG>ATA	p.M249I		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	249					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		CCTCCTGTATGACACCTTATT	0.453													A	85695019	A	A	85695019	3	1	101	1	0	0	0	0	1	0	0	0	556	1290	45	3	761	3	ALX1	12	85695019	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	4584054	85695019	48156876	49	6925											
HAL	3034	broad.mit.edu	37	chr12	96389510	96389510	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgttgtccagcaggcccaggCccttgcaccggcgcacaagg	13	16	0	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr12:96389510C>T	uc001tem.1	-	2	476	c.179G>A	c.(178-180)GGC>GAC	p.G60D	HAL_uc009zti.1_RNA|HAL_uc010suw.1_5'UTR|HAL_uc010sux.1_Missense_Mutation_p.G60D	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	60					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	CAGGCCCAGGCCCTTGCACCG	0.642													T	96389510	T	T	96389510	3	4	101	1	0	0	0	0	1	0	0	0	6947	739	26	3	1874	3	HAL	12	96389510	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	10694491	96389510	37462385	50	6926											
KL	9365	broad.mit.edu	37	chr13	33629339	33629339	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgccaaagtcttcagccttgTtctaccaaaagctgatagag	8	10	3	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr13:33629339T>C	uc001uus.2	+	3	1494	c.1486T>C	c.(1486-1488)TTC>CTC	p.F496L	KL_uc001uur.1_Missense_Mutation_p.F189L	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	496	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TTCAGCCTTGTTCTACCAAAA	0.463													C	33629339	C	C	33629339	3	2	101	1	0	0	0	0	1	0	0	0	8331	1725	60	4	1496	4	KL	13	33629339	Missense_Mutation	SNP	T	TCGA-06-6391-01A-11D-1696-08		33629339	81540539	51	6927											
MYO16	23026	broad.mit.edu	37	chr13	109859183	109859183	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gctctgggacaccaccatttGatgtggcctgaactgcagac	11	12	1	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr13:109859183G>A	uc001vqt.1	+	35	5702	c.5576G>A	c.(5575-5577)TGA>TAA	p.*1859*	MYO16_uc010agk.1_Silent_p.*1881*	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1859					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ACCACCATTTGATGTGGCCTG	0.572													A	109859183	A	A	109859183	2	1	101	1	0	0	0	0	0	0	0	1	10064	1285	45	3		3	MYO16	13	109859183	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	76229844	109859183	5310695	52	6928											
OR5AU1	390445	broad.mit.edu	37	chr14	21623219	21623219	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagatgacagcaactgtgcgGtcctgggtcaaggagtagct	14	8	1	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr14:21623219G>A	uc010tlp.1	-	1	966	c.966C>T	c.(964-966)GAC>GAT	p.D322D		NM_001004731	NP_001004731	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU,	322	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		CAACTGTGCGGTCCTGGGTCA	0.493													A	21623219	A	A	21623219	2	1	101	1	0	0	0	0	0	0	0	1	11147	1252	44	3		3	OR5AU1	14	21623219	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08		21623219	85726321	53	6929											
HEATR5A	25938	broad.mit.edu	37	chr14	31782317	31782317	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctgatgaacatgatccatttCtgataccgtcttctaaacag	6	10	3	4			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr14:31782317C>T	uc001wrf.3	-	22	3496	c.3419G>A	c.(3418-3420)AGA>AAA	p.R1140K	HEATR5A_uc010ami.2_Missense_Mutation_p.R1038K	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1427							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		TGATCCATTTCTGATACCGTC	0.398													T	31782317	T	T	31782317	3	4	101	1	0	0	0	0	1	0	0	0	7031	913	32	3	1878	3	HEATR5A	14	31782317	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	10159098	31782317	75567223	54	6930											
SRP54	6729	broad.mit.edu	37	chr14	35470222	35470222	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtatttaaagaacttgTgaaggtaaaagtatatgaag	10	2	0	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr14:35470222T>C	uc001wso.2	+	4	602	c.251T>C	c.(250-252)GTG>GCG	p.V84A	SRP54_uc010tpp.1_Missense_Mutation_p.V35A|SRP54_uc010tpq.1_Missense_Mutation_p.V20A	NM_003136	NP_003127	P61011	SRP54_HUMAN	signal recognition particle 54kDa isoform 1	84	G-domain.				GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)		AAAGAACTTGTGAAGGTAAAA	0.313													C	35470222	C	C	35470222	3	2	101	1	0	0	0	0	1	0	0	0	15154	1696	59	4	261	4	SRP54	14	35470222	Missense_Mutation	SNP	T	TCGA-06-6391-01A-11D-1696-08	3687905	35470222	71879318	55	6931											
SPINT1	6692	broad.mit.edu	37	chr15	41137192	41137192	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcacgagggaagtgtaccGctcctaccgccagctgcgga	12	15	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr15:41137192G>A	uc001zna.2	+	2	644	c.440G>A	c.(439-441)CGC>CAC	p.R147H	SPINT1_uc001znb.2_Missense_Mutation_p.R147H|SPINT1_uc001znc.2_Missense_Mutation_p.R147H|SPINT1_uc010ucs.1_Missense_Mutation_p.R147H	NM_181642	NP_857593	O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	147						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GAAGTGTACCGCTCCTACCGC	0.582													A	41137192	A	A	41137192	3	1	101	1	0	0	0	0	1	0	0	0	15067	1087	38	1	442	1	SPINT1	15	41137192	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08		41137192	61394200	56	6932											
TPSAB1	7177	broad.mit.edu	37	chr16	1291199	1291199	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggcatcgtcgggggtcaggAggcccccaggagcaagtggc	19	11	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr16:1291199A>G	uc002ckz.2	+	3	159	c.107A>G	c.(106-108)GAG>GGG	p.E36G	TPSAB1_uc010uux.1_5'UTR	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	36	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GGGGGTCAGGAGGCCCCCAGG	0.711													G	1291199	G	G	1291199	3	3	101	1	0	0	0	0	1	0	0	0	16420	304	11	4	113	4	TPSAB1	16	1291199	Missense_Mutation	SNP	A	TCGA-06-6391-01A-11D-1696-08		1291199	89063554	57	6933											
MYH11	4629	broad.mit.edu	37	chr16	15813552	15813552	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ggcatcttccagctctctttGaaagtccttcatctgagcct	7	13	4	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr16:15813552G>C	uc002ddy.2	-	35	5079	c.4972C>G	c.(4972-4974)CAA>GAA	p.Q1658E	MYH11_uc002ddv.2_Missense_Mutation_p.Q1665E|MYH11_uc002ddw.2_Missense_Mutation_p.Q1658E|MYH11_uc002ddx.2_Missense_Mutation_p.Q1665E|MYH11_uc010bvg.2_Missense_Mutation_p.Q1490E|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.Q364E|NDE1_uc002ddz.1_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1658	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						AGCTCTCTTTGAAAGTCCTTC	0.517			T	CBFB	AML								C	15813552	C	C	15813552	3	2	101	1	0	0	0	0	1	0	0	0	10031	1299	45	5	1009	5	MYH11	16	15813552	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	14522353	15813552	74541201	58	6934											
SMG1	23049	broad.mit.edu	37	chr16	18830977	18830977	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaagtgcagctagcttctcCtataaaagccagcagaatct	7	11	3	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr16:18830977C>T	uc002dfm.2	-	56	10105	c.9742_splice	c.e56-1	p.E3248_splice	SMG1_uc010bwb.2_Splice_Site_p.E3108_splice|SMG1_uc010bwa.2_Splice_Site_p.E1979_splice	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1						DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CTAGCTTCTCCTATAAAAGCC	0.413													T	18830977	T	T	18830977	5	4	101	1	0	0	0	0	0	0	1	0	14795	695	24	3	1276	3	SMG1	16	18830977	Splice_Site	SNP	C	TCGA-06-6391-01A-11D-1696-08	3017425	18830977	71523776	59	6935											
DNAH3	55567	broad.mit.edu	37	chr16	21123036	21123036	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacagagatcatgatttagGgccgtagcatcaaggcagaa	11	8	3	3			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr16:21123036G>A	uc010vbe.1	-	14	2010	c.2010C>T	c.(2008-2010)GCC>GCT	p.A670A	DNAH3_uc002die.2_Silent_p.A610A	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	670	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CATGATTTAGGGCCGTAGCAT	0.418													A	21123036	A	A	21123036	2	1	101	1	0	0	0	0	0	0	0	1	4603	1219	43	3		3	DNAH3	16	21123036	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	2292059	21123036	69231717	60	6936											
PRKCB	5579	broad.mit.edu	37	chr16	24166173	24166173	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctccactcctgcttccagAccatggtaacttgtcccatg	7	15	0	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr16:24166173A>G	uc002dmd.2	+	10	1431	c.1234A>G	c.(1234-1236)ACC>GCC	p.T412A	PRKCB_uc002dme.2_Missense_Mutation_p.T412A	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	412	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CTGCTTCCAGACCATGGTAAC	0.582													G	24166173	G	G	24166173	3	3	101	1	0	0	0	0	1	0	0	0	12508	275	10	4	1272	4	PRKCB	16	24166173	Missense_Mutation	SNP	A	TCGA-06-6391-01A-11D-1696-08	3043137	24166173	66188580	61	6937											
OR3A2	4995	broad.mit.edu	37	chr17	3181702	3181702	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acctcattggggccacagaaGttgagcgtggacatggccac	13	11	1	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr17:3181702G>C	uc002fvg.2	-	1	567	c.528C>G	c.(526-528)AAC>AAG	p.N176K		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	176	Extracellular (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GGCCACAGAAGTTGAGCGTGG	0.567													C	3181702	C	C	3181702	3	2	101	1	0	0	0	0	1	0	0	0	11038	1020	36	5	441	5	OR3A2	17	3181702	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08		3181702	78013508	62	6938											
KRT40	125115	broad.mit.edu	37	chr17	39140113	39140113	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcaatggtgttgaagtaaCgctgataatccgggcacacc	10	10	1	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr17:39140113C>T	uc010cxh.1	-	3	574	c.413G>A	c.(412-414)CGT>CAT	p.R138H	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	138	Rod.|Coil 1B.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				GTTGAAGTAACGCTGATAATC	0.483													T	39140113	T	T	39140113	3	4	101	1	0	0	0	0	1	0	0	0	8478	536	19	1	910	1	KRT40	17	39140113	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	35958411	39140113	42055097	63	6939											
SERPINB4	6318	broad.mit.edu	37	chr18	61309010	61309010	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttacctgtaaaaattgatacGtcttttctccgaagagcttg	7	8	2	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr18:61309010G>A	uc002ljf.2	-	4	421	c.335C>T	c.(334-336)ACG>ATG	p.T112M	SERPINB4_uc002lje.2_Missense_Mutation_p.T112M|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	112					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						AAATTGATACGTCTTTTCTCC	0.423													A	61309010	A	A	61309010	3	1	101	1	0	0	0	0	1	0	0	0	14103	1145	40	1	857	1	SERPINB4	18	61309010	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08		61309010	16768238	64	6940											
BEST2	54831	broad.mit.edu	37	chr19	12863444	12863444	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcccgagtggcgaacgcccGcttcggtggcttctcccagc	13	16	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr19:12863444G>A	uc002mux.2	+	1	38	c.38G>A	c.(37-39)CGC>CAC	p.R13H		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	13	Cytoplasmic (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						GCGAACGCCCGCTTCGGTGGC	0.657													A	12863444	A	A	12863444	3	1	101	1	0	0	0	0	1	0	0	0	1405	1087	38	1	40	1	BEST2	19	12863444	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08		12863444	46265539	65	6941											
SLC35E1	79939	broad.mit.edu	37	chr19	16664592	16664592	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggccgtactgatagtccccGtgctgggggaagaggaggcc	17	11	0	2	rs139815009		TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr19:16664592G>A	uc010xph.1	-	6	1149	c.1131C>T	c.(1129-1131)CAC>CAT	p.H377H	MED26_uc002nee.2_RNA	NM_024881	NP_079157	Q96K37	S35E1_HUMAN	solute carrier family 35, member E1	377					transport	integral to membrane				ovary(1)|central_nervous_system(1)	2						GATAGTCCCCGTGCTGGGGGA	0.582													A	16664592	A	A	16664592	2	1	101	1	0	0	0	0	0	0	0	1	14584	1136	40	1		1	SLC35E1	19	16664592	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	3801148	16664592	42464391	66	6942											
FCGBP	8857	broad.mit.edu	37	chr19	40411954	40411954	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcggtccgcagctggaggacTcacaggacaccaggccgccc	14	16	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr19:40411954T>C	uc002omp.3	-	7	3682	c.3674A>G	c.(3673-3675)GAG>GGG	p.E1225G		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1225	Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCTGGAGGACTCACAGGACAC	0.677													C	40411954	C	C	40411954	3	2	101	1	0	0	0	0	1	0	0	0	5778	1551	54	4	12663	4	FCGBP	19	40411954	Missense_Mutation	SNP	T	TCGA-06-6391-01A-11D-1696-08	23747362	40411954	18717029	67	6943											
CYP2B6	1555	broad.mit.edu	37	chr19	41515193	41515193	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaagtttacaaaaacctgCaggaaatcaatgcttacatt	7	8	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr19:41515193C>T	uc002opr.1	+	5	722	c.715C>T	c.(715-717)CAG>TAG	p.Q239*	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	239					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CAAAAACCTGCAGGAAATCAA	0.522													T	41515193	T	T	41515193	4	4	101	1	0	0	0	0	0	1	0	0	4164	711	25	3	733	3	CYP2B6	19	41515193	Nonsense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	1103239	41515193	17613790	68	6944											
C20orf71	128861	broad.mit.edu	37	chr20	31811632	31811632	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccagttattgctcagggccTcataaagcacaacgcagaaa	8	11	2	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr20:31811632T>C	uc002wyr.2	+	2	351	c.143T>C	c.(142-144)CTC>CCC	p.L48P	C20orf71_uc002wys.2_Missense_Mutation_p.L48P	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium	48						extracellular region	lipid binding			ovary(1)|skin(1)	2						GCTCAGGGCCTCATAAAGCAC	0.373													C	31811632	C	C	31811632	3	2	101	1	0	0	0	0	1	0	0	0	2117	1551	54	4	149	4	C20orf71	20	31811632	Missense_Mutation	SNP	T	TCGA-06-6391-01A-11D-1696-08		31811632	31213888	69	6945											
CASS4	57091	broad.mit.edu	37	chr20	55021057	55021057	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggggccccgtggtcctgaaGgtgagccttgttcaggggcc	17	12	1	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chr20:55021057G>A	uc002xxp.2	+	4	786	c.561G>A	c.(559-561)AAG>AAA	p.K187K	CASS4_uc002xxq.3_Silent_p.K187K|CASS4_uc002xxr.2_Silent_p.K187K|CASS4_uc010zze.1_Silent_p.K133K|CASS4_uc010gio.2_Silent_p.K187K	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	187					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						TGGTCCTGAAGGTGAGCCTTG	0.622													A	55021057	A	A	55021057	2	1	101	1	0	0	0	0	0	0	0	1	2683	1014	35	3		3	CASS4	20	55021057	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	23209425	55021057	8004463	70	6946											
CDKL5	6792	broad.mit.edu	37	chrX	18622176	18622176	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ttgctggagctagtcttagtCcactgcacaccaaaacctac	7	13	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chrX:18622176C>G	uc004cym.2	+	12	1385	c.1132C>G	c.(1132-1134)CCA>GCA	p.P378A	CDKL5_uc004cyn.2_Missense_Mutation_p.P378A	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	378					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					TAGTCTTAGTCCACTGCACAC	0.522													G	18622176	G	G	18622176	3	3	101	1	0	0	0	0	1	0	0	0	3157	855	30	5	1174	5	CDKL5	23	18622176	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08		18622176	136648384	71	6947											
PHEX	5251	broad.mit.edu	37	chrX	22051086	22051086	+	Translation_Start_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccagccaccaaaccacgaaaAgtgactttcttctcgtgtgc	7	14	2	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chrX:22051086A>T	uc004dah.2	+	1	166	c.-37A>T	c.(-39--35)AAAGT>AATGT		PHEX_uc011mjr.1_Translation_Start_Site	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase						biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						AACCACGAAAAGTGACTTTCT	0.502													T	22051086	T	T	22051086	1	4	101	1	0	0	0	0	0	0	0	0	11819	87	3	5		5	PHEX	23	22051086	Translation_Start_Site	SNP	A	TCGA-06-6391-01A-11D-1696-08	3428910	22051086	133219474	72	6948											
DCAF8L1	139425	broad.mit.edu	37	chrX	27998447	27998447	+	Silent	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	atagagattgtatacagtccGactttcttatcattttctct	5	8	3	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chrX:27998447G>C	uc004dbx.1	-	1	1120	c.1005C>G	c.(1003-1005)GTC>GTG	p.V335V		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	335	WD 4.									ovary(3)|skin(1)	4						TATACAGTCCGACTTTCTTAT	0.418													C	27998447	C	C	27998447	2	2	101	1	0	0	0	0	0	0	0	1	4277	1045	37	5		5	DCAF8L1	23	27998447	Silent	SNP	G	TCGA-06-6391-01A-11D-1696-08	5947361	27998447	127272113	73	6949											
CXorf22	170063	broad.mit.edu	37	chrX	35966473	35966473	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cggccaattacccatcctcaTttttccaactagtggtatcg	6	13	1	0			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chrX:35966473T>A	uc004ddj.2	+	4	619	c.560T>A	c.(559-561)ATT>AAT	p.I187N	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	187										large_intestine(1)|lung(1)|ovary(1)	3						CCCATCCTCATTTTTCCAACT	0.403													A	35966473	A	A	35966473	3	1	101	1	0	0	0	0	1	0	0	0	4102	1493	52	5	574	5	CXorf22	23	35966473	Missense_Mutation	SNP	T	TCGA-06-6391-01A-11D-1696-08	7968026	35966473	119304087	74	6950											
OTC	5009	broad.mit.edu	37	chrX	38260563	38260563	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ggcagatgcagtattggctcGagtgtataaacaatcagatt	11	6	1	2	rs68026851		TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chrX:38260563G>C	uc004def.3	+	5	636	c.422G>C	c.(421-423)CGA>CCA	p.R141P		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor	141		Ornithine.|Carbamoyl phosphate.	R -> Q (in OTCD; activity is 100-fold lower; most common point mutation).|R -> P (in OTCD).		arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	GTATTGGCTCGAGTGTATAAA	0.378													C	38260563	C	C	38260563	3	2	101	1	0	0	0	0	1	0	0	0	11301	1058	37	5	440	5	OTC	23	38260563	Missense_Mutation	SNP	G	TCGA-06-6391-01A-11D-1696-08	2294090	38260563	117009997	75	6951											
MAOB	4129	broad.mit.edu	37	chrX	43626865	43626865	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gatgggctgtgcagggacatCctaggttcagaaaacattgg	14	7	1	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chrX:43626865C>G	uc004dfz.3	-	15	1587	c.1411G>C	c.(1411-1413)GAT>CAT	p.D471H	MAOB_uc011mkx.1_3'UTR|MAOB_uc011mky.1_Missense_Mutation_p.D455H	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	471	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	GCAGGGACATCCTAGGTTCAG	0.348													G	43626865	G	G	43626865	3	3	101	1	0	0	0	0	1	0	0	0	9226	869	30	5	155	5	MAOB	23	43626865	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	5366302	43626865	111643695	76	6952											
ATRX	546	broad.mit.edu	37	chrX	76938530	76938530	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gtgactcatcctgctcacctCtttgaggattgctagcattt	8	11	3	2			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chrX:76938530C>A	uc004ecp.3	-	9	2450	c.2218G>T	c.(2218-2220)GAG>TAG	p.E740*	ATRX_uc004ecq.3_Nonsense_Mutation_p.E702*|ATRX_uc004eco.3_Nonsense_Mutation_p.E525*|ATRX_uc004ecr.2_Nonsense_Mutation_p.E672*|ATRX_uc010nlx.1_Nonsense_Mutation_p.E711*|ATRX_uc010nly.1_Nonsense_Mutation_p.E685*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	740					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CTGCTCACCTCTTTGAGGATT	0.358			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						A	76938530	A	A	76938530	4	1	101	1	0	0	0	0	0	1	0	0	1208	922	32	5	5368	5	ATRX	23	76938530	Nonsense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	33311665	76938530	78332030	77	6953											
RPL36A	6173	broad.mit.edu	37	chrX	100646547	100646547	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaggattctctgtacgCccagggtaagatggattccg	14	9	1	1			TCGA-06-6391-01A-11D-1696-08	TCGA-06-6391-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	40fc77dc-46df-4487-925f-1d87c5326661	db316976-37ef-47d9-b41d-895875794399	g.chrX:100646547C>T	uc004ehk.2	+	2	188	c.104C>T	c.(103-105)GCC>GTC	p.A35V	BTK_uc010nno.2_5'Flank|RPL36A_uc004ehj.1_Missense_Mutation_p.A35V	NM_021029	NP_066357	P83881	RL36A_HUMAN	ribosomal protein L36a	35					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						TCTCTGTACGCCCAGGGTAAG	0.483													T	100646547	T	T	100646547	3	4	101	1	0	0	0	0	1	0	0	0	13587	739	26	3	110	3	RPL36A	23	100646547	Missense_Mutation	SNP	C	TCGA-06-6391-01A-11D-1696-08	23708017	100646547	54624013	78	6954											
AGRN	375790	broad.mit.edu	37	chr1	985841	985841	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaggtcgtgttcctggcaCgaggccccagcggcctcctg	15	14	0	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr1:985841C>T	uc001ack.1	+	29	5061	c.5011C>T	c.(5011-5013)CGA>TGA	p.R1671*		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1671	Laminin G-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GTTCCTGGCACGAGGCCCCAG	0.677													T	985841	T	T	985841	4	4	102	1	0	0	0	0	0	1	0	0	397	528	19	1	5125	1	AGRN	1	985841	Nonsense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08		985841	248264780	1	6955											
ARHGEF11	9826	broad.mit.edu	37	chr1	156917716	156917716	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggggaaggagggtatctGtgcagaaccccaaactgggg	18	7	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr1:156917716G>A	uc001fqo.2	-	24	3106	c.2066C>T	c.(2065-2067)ACA>ATA	p.T689I	ARHGEF11_uc010phu.1_Missense_Mutation_p.T105I|ARHGEF11_uc001fqn.2_Missense_Mutation_p.T729I	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	689					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GAGGGTATCTGTGCAGAACCC	0.562													A	156917716	A	A	156917716	3	1	102	1	0	0	0	0	1	0	0	0	896	1377	48	3	2570	3	ARHGEF11	1	156917716	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	155931875	156917716	92332905	2	6956											
OBSCN	84033	broad.mit.edu	37	chr1	228494214	228494214	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagctgcaggccaatgggcGccgggagccacggcttcagg	17	13	1	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr1:228494214G>A	uc009xez.1	+	44	11845	c.11801G>A	c.(11800-11802)CGC>CAC	p.R3934H	OBSCN_uc001hsn.2_Missense_Mutation_p.R3934H	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3934	Ig-like 40.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCCAATGGGCGCCGGGAGCCA	0.652													A	228494214	A	A	228494214	3	1	102	1	0	0	0	0	1	0	0	0	10812	1087	38	1	11971	1	OBSCN	1	228494214	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	71576498	228494214	20756407	3	6957											
SH3RF3	344558	broad.mit.edu	37	chr2	110015136	110015136	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctccctgccctctgactccGgcgctgtggccagcgtggcc	12	19	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr2:110015136G>A	uc010ywt.1	+	4	1036	c.1036G>A	c.(1036-1038)GGC>AGC	p.G346S		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	346							zinc ion binding			ovary(1)	1						CTCTGACTCCGGCGCTGTGGC	0.602													A	110015136	A	A	110015136	3	1	102	1	0	0	0	0	1	0	0	0	14260	1116	39	2	1050	2	SH3RF3	2	110015136	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08		110015136	133184237	4	6958											
TMEM163	81615	broad.mit.edu	37	chr2	135470799	135470799	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaccgcgagggccagggtgAcaatgatggagaaccaggac	15	11	0	3			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr2:135470799A>G	uc002ttx.2	-	2	359	c.293T>C	c.(292-294)GTC>GCC	p.V98A	TMEM163_uc002tty.2_RNA	NM_030923	NP_112185	Q8TC26	TM163_HUMAN	transmembrane protein 163	98	Helical; (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(221;0.154)		GGCCAGGGTGACAATGATGGA	0.517													G	135470799	G	G	135470799	3	3	102	1	0	0	0	0	1	0	0	0	16075	275	10	4	604	4	TMEM163	2	135470799	Missense_Mutation	SNP	A	TCGA-06-6693-01A-11D-1845-08	25455663	135470799	107728574	5	6959											
PROS1	5627	broad.mit.edu	37	chr3	93646100	93646100	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccataaatgcttaccgtttcCgggtcattttcaaagacctc	6	12	2	1	rs6121	by1000genomes	TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr3:93646100C>T	uc003drb.3	-	2	569	c.228G>A	c.(226-228)CCG>CCA	p.P76P	PROS1_uc010hoo.2_5'UTR|PROS1_uc003dqz.3_5'UTR	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	76	Gla.		P -> L.		leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTACCGTTTCCGGGTCATTTT	0.388													T	93646100	T	T	93646100	2	4	102	1	0	0	0	0	0	0	0	1	12558	639	23	2		2	PROS1	3	93646100	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08		93646100	104376330	6	6960											
TNIK	23043	broad.mit.edu	37	chr3	170819385	170819385	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcggtttgtttcttcaatcCggagttctcttagttctttg	10	8	4	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr3:170819385C>T	uc003fhh.2	-	22	2789	c.2444G>A	c.(2443-2445)CGG>CAG	p.R815Q	TNIK_uc003fhi.2_Missense_Mutation_p.R760Q|TNIK_uc003fhj.2_Missense_Mutation_p.R786Q|TNIK_uc003fhk.2_Missense_Mutation_p.R807Q|TNIK_uc003fhl.2_Missense_Mutation_p.R731Q|TNIK_uc003fhm.2_Missense_Mutation_p.R752Q|TNIK_uc003fhn.2_Missense_Mutation_p.R778Q|TNIK_uc003fho.2_Missense_Mutation_p.R723Q|TNIK_uc003fhg.2_5'UTR	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	815	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TTCTTCAATCCGGAGTTCTCT	0.453													T	170819385	T	T	170819385	3	4	102	1	0	0	0	0	1	0	0	0	16310	652	23	2	1686	2	TNIK	3	170819385	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08	77173285	170819385	27203045	7	6961											
ARAP2	116984	broad.mit.edu	37	chr4	36085016	36085016	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggaggcttcattttctttttCactccacgataaaacttcat	5	10	4	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr4:36085016C>T	uc003gsq.1	-	29	4820	c.4482G>A	c.(4480-4482)GTG>GTA	p.V1494V		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1494	PH 5.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TTTTCTTTTTCACTCCACGAT	0.313													T	36085016	T	T	36085016	2	4	102	1	0	0	0	0	0	0	0	1	839	813	29	3		3	ARAP2	4	36085016	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08		36085016	155069260	8	6962											
FRAS1	80144	broad.mit.edu	37	chr4	79204019	79204019	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgcaaggtgtgtgagtgcCgaggggctcaggtaacttgc	16	8	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr4:79204019C>T	uc003hlb.2	+	12	1593	c.1153C>T	c.(1153-1155)CGA>TGA	p.R385*	FRAS1_uc003hkw.2_Nonsense_Mutation_p.R385*|FRAS1_uc003hky.1_Nonsense_Mutation_p.R89*|FRAS1_uc003hkz.2_Nonsense_Mutation_p.R89*	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	385	VWFC 6.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GTGTGAGTGCCGAGGGGCTCA	0.537													T	79204019	T	T	79204019	4	4	102	1	0	0	0	0	0	1	0	0	6042	644	23	2	1199	2	FRAS1	4	79204019	Nonsense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08	43119003	79204019	111950257	9	6963											
HPGD	3248	broad.mit.edu	37	chr4	175439163	175439163	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttcccagtttttctcattatTcactccagcattattgacca	3	12	2	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr4:175439163T>A	uc003itu.2	-	3	473	c.283A>T	c.(283-285)AAT>TAT	p.N95Y	HPGD_uc003itv.2_Missense_Mutation_p.N95Y|HPGD_uc011ckf.1_Intron|HPGD_uc010irp.2_5'UTR|HPGD_uc010irq.2_Missense_Mutation_p.N95Y|HPGD_uc011ckg.1_Intron|HPGD_uc011ckh.1_5'UTR|HPGD_uc003itw.2_Missense_Mutation_p.N95Y|HPGD_uc003itx.2_Missense_Mutation_p.N95Y	NM_000860	NP_000851	P15428	PGDH_HUMAN	hydroxyprostaglandin dehydrogenase 15-(NAD)	95					female pregnancy|lipoxygenase pathway|negative regulation of cell cycle|parturition|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|NAD+ binding|prostaglandin E receptor activity|protein homodimerization activity				0		Prostate(90;0.00763)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;2.6e-18)|Epithelial(43;4.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.23e-09)|GBM - Glioblastoma multiforme(59;0.00176)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.0253)	NADH(DB00157)	TTCTCATTATTCACTCCAGCA	0.279													A	175439163	A	A	175439163	3	1	102	1	0	0	0	0	1	0	0	0	7334	1783	62	5	537	5	HPGD	4	175439163	Missense_Mutation	SNP	T	TCGA-06-6693-01A-11D-1845-08	96235144	175439163	15715113	10	6964											
PLCXD3	345557	broad.mit.edu	37	chr5	41382349	41382349	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttatggtgatctgtgaggaAtgcattgatctcctcaaggc	11	8	3	3			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr5:41382349A>G	uc003jmm.1	-	2	493	c.391T>C	c.(391-393)TTC>CTC	p.F131L		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	131	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						TCTGTGAGGAATGCATTGATC	0.433													G	41382349	G	G	41382349	3	3	102	1	0	0	0	0	1	0	0	0	12043	101	4	4	582	4	PLCXD3	5	41382349	Missense_Mutation	SNP	A	TCGA-06-6693-01A-11D-1845-08		41382349	139532911	11	6965											
RSPO3	84870	broad.mit.edu	37	chr6	127469958	127469958	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aagtggatattatggaactcGatatccagatataaataagt	8	4	0	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr6:127469958G>A	uc003qar.2	+	2	553	c.263G>A	c.(262-264)CGA>CAA	p.R88Q	RSPO3_uc003qas.1_Missense_Mutation_p.R88Q	NM_032784	NP_116173	Q9BXY4	RSPO3_HUMAN	R-spondin 3 precursor	88						extracellular region	heparin binding				0				GBM - Glioblastoma multiforme(226;0.0555)		TATGGAACTCGATATCCAGAT	0.363													A	127469958	A	A	127469958	3	1	102	1	0	0	0	0	1	0	0	0	13711	1058	37	2	269	2	RSPO3	6	127469958	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08		127469958	43645109	12	6966											
ZBTB2	57621	broad.mit.edu	37	chr6	151687542	151687542	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggaagatgcttccagattgGtctcctccccgggaggaggg	15	10	1	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr6:151687542G>T	uc003qoh.2	-	3	794	c.659C>A	c.(658-660)ACC>AAC	p.T220N		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		TTCCAGATTGGTCTCCTCCCC	0.552													T	151687542	T	T	151687542	3	4	102	1	0	0	0	0	1	0	0	0	17525	1261	44	5	889	5	ZBTB2	6	151687542	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	24217584	151687542	19427525	13	6967											
MACC1	346389	broad.mit.edu	37	chr7	20180649	20180649	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tattaaaactccagttaattCtctccagtgtttagtcacag	5	9	2	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr7:20180649C>A	uc003sus.3	-	7	2788	c.2479G>T	c.(2479-2481)GAA>TAA	p.E827*	MACC1_uc010kug.2_Nonsense_Mutation_p.E827*	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	827					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						CCAGTTAATTCTCTCCAGTGT	0.383													A	20180649	A	A	20180649	4	1	102	1	0	0	0	0	0	1	0	0	9143	922	32	5	83	5	MACC1	7	20180649	Nonsense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08		20180649	138958014	14	6968											
EGFR	1956	broad.mit.edu	37	chr7	55221763	55221763	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	acctgccccccactcatgctCtacaaccccaccacgtacca	3	22	2	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr7:55221763C>G	uc003tqk.2	+	7	1053	c.807C>G	c.(805-807)CTC>CTG	p.L269L	EGFR_uc003tqh.2_Silent_p.L269L|EGFR_uc003tqi.2_Silent_p.L269L|EGFR_uc003tqj.2_Silent_p.L269L|EGFR_uc010kzg.1_Silent_p.L224L|EGFR_uc011kco.1_Silent_p.L216L|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	269	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CACTCATGCTCTACAACCCCA	0.577		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			G	55221763	G	G	55221763	2	3	102	1	0	0	0	0	0	0	0	1	4967	900	32	5		5	EGFR	7	55221763	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08	35041114	55221763	103916900	15	6969											
EPHA1	2041	broad.mit.edu	37	chr7	143097029	143097029	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcacccgggttgtggaaagCgaggtagaggccacggcggg	20	9	0	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr7:143097029C>T	uc003wcz.2	-	4	637	c.550G>A	c.(550-552)GCT>ACT	p.A184T		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	184	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TTGTGGAAAGCGAGGTAGAGG	0.617													T	143097029	T	T	143097029	3	4	102	1	0	0	0	0	1	0	0	0	5165	768	27	1	2440	1	EPHA1	7	143097029	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08	87875266	143097029	16041634	16	6970											
BNC2	54796	broad.mit.edu	37	chr9	16437497	16437497	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcgagacatgatggcccagCggtccagcaccttgccagca	11	15	0	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr9:16437497C>T	uc003zml.2	-	6	835	c.695G>A	c.(694-696)CGC>CAC	p.R232H	BNC2_uc011lmw.1_Missense_Mutation_p.R137H|BNC2_uc003zmm.2_Missense_Mutation_p.R190H|BNC2_uc003zmq.1_Missense_Mutation_p.R246H|BNC2_uc003zmr.1_Missense_Mutation_p.R269H|BNC2_uc003zmp.1_Missense_Mutation_p.R260H|BNC2_uc010mij.1_Missense_Mutation_p.R154H|BNC2_uc011lmv.1_Missense_Mutation_p.R58H|BNC2_uc003zmo.1_Missense_Mutation_p.R154H|BNC2_uc003zmj.2_5'UTR|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_5'UTR|BNC2_uc003zmn.1_5'UTR	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GATGGCCCAGCGGTCCAGCAC	0.448													T	16437497	T	T	16437497	3	4	102	1	0	0	0	0	1	0	0	0	1475	768	27	1	2612	1	BNC2	9	16437497	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08		16437497	124775934	17	6971											
NOL8	55035	broad.mit.edu	37	chr9	95078415	95078415	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tattttgagggatcatatttGatgatgttacgcaagtcaag	10	4	2	3			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr9:95078415G>C	uc004arv.2	-	7	829	c.492C>G	c.(490-492)ATC>ATG	p.I164M	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.I96M	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	164					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						GATCATATTTGATGATGTTAC	0.338													C	95078415	C	C	95078415	3	2	102	1	0	0	0	0	1	0	0	0	10527	1280	45	5	3055	5	NOL8	9	95078415	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	78640918	95078415	46135016	18	6972											
KIAA0368	23392	broad.mit.edu	37	chr9	114145511	114145511	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctgagggctcgaacttccgtCacggtgctcatcattccttt	9	13	3	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr9:114145511C>T	uc004bfe.1	-	36	4317	c.4317G>A	c.(4315-4317)GTG>GTA	p.V1439V		NM_001080398	NP_001073867			KIAA0368 protein												0						GAACTTCCGTCACGGTGCTCA	0.483													T	114145511	T	T	114145511	2	4	102	1	0	0	0	0	0	0	0	1	8171	813	29	3		3	KIAA0368	9	114145511	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08	19067096	114145511	27067920	19	6973											
DIP2C	22982	broad.mit.edu	37	chr10	395316	395316	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgccgtcctgaaggtggcCcctctccatcagcatcacgg	11	16	3	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr10:395316C>T	uc001ifp.2	-	25	3154	c.3064G>A	c.(3064-3066)GGC>AGC	p.G1022S	DIP2C_uc009xhi.1_Missense_Mutation_p.G408S	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	1022						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		TGAAGGTGGCCCCTCTCCATC	0.652													T	395316	T	T	395316	3	4	102	1	0	0	0	0	1	0	0	0	4529	623	22	3	1658	3	DIP2C	10	395316	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08		395316	135139431	20	6974											
CALY	50632	broad.mit.edu	37	chr10	135142374	135142374	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcacctggtcagggagtggCggctggagctggctgatgtc	17	10	2	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr10:135142374C>T	uc001lmo.2	-	2	278	c.120G>A	c.(118-120)CCG>CCA	p.P40P		NM_015722	NP_056537	Q9NYX4	CALY_HUMAN	dopamine receptor D1 interacting protein	40	Extracellular (Potential).				clathrin coat assembly|dopamine receptor signaling pathway|endocytosis|positive regulation of endocytosis	cytoplasmic vesicle membrane|integral to plasma membrane	clathrin light chain binding|dopamine receptor binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;6.94e-06)|OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)	Apomorphine(DB00714)|Clozapine(DB00363)|Flupenthixol(DB00875)|Trifluoperazine(DB00831)	CAGGGAGTGGCGGCTGGAGCT	0.637													T	135142374	T	T	135142374	2	4	102	1	0	0	0	0	0	0	0	1	2595	755	27	1		1	CALY	10	135142374	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08	134747058	135142374	392373	21	6975											
ANO9	338440	broad.mit.edu	37	chr11	419726	419726	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tctccagcacctgcagccagGtccctgcaccagagcagtgg	11	16	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr11:419726G>T	uc001lpi.2	-	20	1875	c.1790C>A	c.(1789-1791)ACC>AAC	p.T597N	SIGIRR_uc001lpf.2_5'Flank|SIGIRR_uc001lpe.1_5'Flank|ANO9_uc001lph.2_Missense_Mutation_p.T290N|ANO9_uc010qvv.1_Missense_Mutation_p.T453N	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	597	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CTGCAGCCAGGTCCCTGCACC	0.637													T	419726	T	T	419726	3	4	102	1	0	0	0	0	1	0	0	0	704	1261	44	5	574	5	ANO9	11	419726	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08		419726	134586790	22	6976											
CHRNA10	57053	broad.mit.edu	37	chr11	3688571	3688571	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacaccttctcgcctgagtcGgcaggcaggtggaaggcgag	16	11	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr11:3688571G>A	uc001lyf.2	-	4	858	c.786C>T	c.(784-786)GCC>GCT	p.A262A	CHRNA10_uc010qxt.1_Silent_p.A56A|CHRNA10_uc010qxu.1_Silent_p.A56A	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	262					elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	CGCCTGAGTCGGCAGGCAGGT	0.706													A	3688571	A	A	3688571	2	1	102	1	0	0	0	0	0	0	0	1	3382	1103	39	2		2	CHRNA10	11	3688571	Silent	SNP	G	TCGA-06-6693-01A-11D-1845-08	3268845	3688571	131317945	23	6977											
OR52E4	390081	broad.mit.edu	37	chr11	5906315	5906315	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttcttttatgacacatcgtTttggccaaaacattccccac	4	12	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr11:5906315T>A	uc010qzs.1	+	1	793	c.793T>A	c.(793-795)TTT>ATT	p.F265I	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GACACATCGTTTTGGCCAAAA	0.423													A	5906315	A	A	5906315	3	1	102	1	0	0	0	0	1	0	0	0	11116	1841	64	5	795	5	OR52E4	11	5906315	Missense_Mutation	SNP	T	TCGA-06-6693-01A-11D-1845-08	2217744	5906315	129100201	24	6978											
OR5L1	219437	broad.mit.edu	37	chr11	55579782	55579782	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gccaccgtgttctacacagtCgtgattcctatgctgaactc	8	13	1	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr11:55579782C>T	uc001nhw.1	+	1	840	c.840C>T	c.(838-840)GTC>GTT	p.V280V		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TCTACACAGTCGTGATTCCTA	0.453													T	55579782	T	T	55579782	2	4	102	1	0	0	0	0	0	0	0	1	11170	871	31	2		2	OR5L1	11	55579782	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08	49673467	55579782	79426734	25	6979											
PACS1	55690	broad.mit.edu	37	chr11	65977846	65977846	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtttcagggttcaaaaagaaTtcttcgctccaacgagatcg	9	9	3	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr11:65977846T>C	uc001oha.1	+	3	592	c.458T>C	c.(457-459)ATT>ACT	p.I153T	PACS1_uc001ogz.1_Missense_Mutation_p.I153T	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	153					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TCAAAAAGAATTCTTCGCTCC	0.318													C	65977846	C	C	65977846	3	2	102	1	0	0	0	0	1	0	0	0	11372	1493	52	4	468	4	PACS1	11	65977846	Missense_Mutation	SNP	T	TCGA-06-6693-01A-11D-1845-08	10398064	65977846	69028670	26	6980											
KIAA1377	57562	broad.mit.edu	37	chr11	101818772	101818772	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atctctttagtttcccgaaaAccagttcctccattagaaga	5	11	1	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr11:101818772A>G	uc001pgm.2	+	4	675	c.405A>G	c.(403-405)AAA>AAG	p.K135K	KIAA1377_uc001pgn.2_Silent_p.K91K|KIAA1377_uc009yxa.1_5'UTR	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	135							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TTTCCCGAAAACCAGTTCCTC	0.343													G	101818772	G	G	101818772	2	3	102	1	0	0	0	0	0	0	0	1	8227	40	2	4		4	KIAA1377	11	101818772	Silent	SNP	A	TCGA-06-6693-01A-11D-1845-08	35840926	101818772	33187744	27	6981											
OR6M1	390261	broad.mit.edu	37	chr11	123676994	123676994	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaccacgaagagagatattcGaatctccaggagagctggga	12	8	1	3	rs150135307		TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr11:123676994G>A	uc010rzz.1	-	1	64	c.64C>T	c.(64-66)CGA>TGA	p.R22*		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		AGAGATATTCGAATCTCCAGG	0.458													A	123676994	A	A	123676994	4	1	102	1	0	0	0	0	0	1	0	0	11205	1066	37	2	880	2	OR6M1	11	123676994	Nonsense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	21858222	123676994	11329522	28	6982											
PPP1R12A	4659	broad.mit.edu	37	chr12	80191152	80191152	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctattgttttctcagcttcTtgaagatcagttaatgtcac	6	9	4	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr12:80191152T>C	uc001syz.2	-	16	2382	c.2115A>G	c.(2113-2115)CAA>CAG	p.Q705Q	PPP1R12A_uc010suc.1_Silent_p.Q618Q|PPP1R12A_uc001sza.2_Silent_p.Q649Q|PPP1R12A_uc010sud.1_Silent_p.Q705Q|PPP1R12A_uc001szb.2_Silent_p.Q705Q|PPP1R12A_uc001szc.2_Silent_p.Q646Q	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	705	Interaction with ROCK2.					contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						TCTCAGCTTCTTGAAGATCAG	0.244													C	80191152	C	C	80191152	2	2	102	1	0	0	0	0	0	0	0	1	12354	1606	56	4		4	PPP1R12A	12	80191152	Silent	SNP	T	TCGA-06-6693-01A-11D-1845-08		80191152	53660743	29	6983											
GPR109A	338442	broad.mit.edu	37	chr12	123187006	123187006	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagctgagagtgataaagaaCgccaggtccaccgagcggta	13	9	0	3			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr12:123187006C>T	uc001ucx.1	-	1	899	c.825G>A	c.(823-825)GCG>GCA	p.A275A	GPR81_uc001ucw.1_Intron	NM_177551	NP_808219	Q8TDS4	HCAR2_HUMAN	G protein-coupled receptor 109A	275	Helical; Name=7; (Potential).				negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	TGATAAAGAACGCCAGGTCCA	0.542													T	123187006	T	T	123187006	2	4	102	1	0	0	0	0	0	0	0	1	6625	523	19	1		1	GPR109A	12	123187006	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08	42995854	123187006	10664889	30	6984											
CLEC14A	161198	broad.mit.edu	37	chr14	38724093	38724093	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggaagtcgtagaattaaactTggaaatcacgctccctgatg	10	8	1	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr14:38724093T>A	uc001wum.1	-	1	1482	c.1135A>T	c.(1135-1137)AAG>TAG	p.K379*		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	379	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GAATTAAACTTGGAAATCACG	0.502													A	38724093	A	A	38724093	4	1	102	1	0	0	0	0	0	1	0	0	3499	1821	63	5	341	5	CLEC14A	14	38724093	Nonsense_Mutation	SNP	T	TCGA-06-6693-01A-11D-1845-08		38724093	68625447	31	6985											
CLEC14A	161198	broad.mit.edu	37	chr14	38724649	38724649	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgcagctggaagggcgcGcgatagctcaagttagaggc	16	9	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr14:38724649G>A	uc001wum.1	-	1	926	c.579C>T	c.(577-579)CGC>CGT	p.R193R		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	193	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GGAAGGGCGCGCGATAGCTCA	0.542													A	38724649	A	A	38724649	2	1	102	1	0	0	0	0	0	0	0	1	3499	1074	38	1		1	CLEC14A	14	38724649	Silent	SNP	G	TCGA-06-6693-01A-11D-1845-08	556	38724649	68624891	32	6986											
NIN	51199	broad.mit.edu	37	chr14	51227078	51227078	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgcttttcataatggcgcacCtgaaggcacagagtgacacc	10	11	1	3			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr14:51227078C>G	uc001wym.2	-	17	2088	c.1897_splice	c.e17-1	p.V633_splice	NIN_uc001wyi.2_Splice_Site_p.V633_splice|NIN_uc001wyj.2_Splice_Site|NIN_uc001wyk.2_Splice_Site_p.V633_splice|NIN_uc010tqp.1_Splice_Site_p.V639_splice|NIN_uc001wyo.2_Splice_Site_p.V633_splice	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5						centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					AATGGCGCACCTGAAGGCACA	0.453			T	PDGFRB	MPD								G	51227078	G	G	51227078	5	3	102	1	0	0	0	0	0	0	1	0	10417	695	24	5	4713	5	NIN	14	51227078	Splice_Site	SNP	C	TCGA-06-6693-01A-11D-1845-08	12502429	51227078	56122462	33	6987											
SIX4	51804	broad.mit.edu	37	chr14	61180418	61180418	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgtaggaactatttccccaaGggcagcctgagtcataggga	12	9	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr14:61180418G>C	uc001xfc.2	-	3	2053	c.2053C>G	c.(2053-2055)CTT>GTT	p.L685V		NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	685						nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		ATTTCCCCAAGGGCAGCCTGA	0.473													C	61180418	C	C	61180418	3	2	102	1	0	0	0	0	1	0	0	0	14349	1000	35	5	296	5	SIX4	14	61180418	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	9953340	61180418	46169122	34	6988											
YY1	7528	broad.mit.edu	37	chr14	100705804	100705804	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccggccaccaccaccaccacCatcaccaccaccaccacccg	3	26	1	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr14:100705804C>G	uc001ygy.1	+	1	703	c.223C>G	c.(223-225)CAT>GAT	p.H75D		NM_003403	NP_003394	P25490	TYY1_HUMAN	YY1 transcription factor	75	Poly-His.				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)				ccaccaccaccatcaccacca	0.313													G	100705804	G	G	100705804	3	3	102	1	0	0	0	0	1	0	0	0	17504	594	21	5	225	5	YY1	14	100705804	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08	39525386	100705804	6643736	35	6989											
BAHD1	22893	broad.mit.edu	37	chr15	40751318	40751318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctaaaactgagccaggagCgggagctacccctgcggctg	13	13	0	1	rs143744499		TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr15:40751318C>T	uc001zlu.2	+	2	726	c.655C>T	c.(655-657)CGG>TGG	p.R219W	BAHD1_uc001zlt.2_Missense_Mutation_p.R219W|BAHD1_uc010bbp.1_Missense_Mutation_p.R219W|BAHD1_uc001zlv.2_Missense_Mutation_p.R219W	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	219					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		GAGCCAGGAGCGGGAGCTACC	0.642													T	40751318	T	T	40751318	3	4	102	1	0	0	0	0	1	0	0	0	1297	759	27	1	657	1	BAHD1	15	40751318	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08		40751318	61780074	36	6990											
VPS13C	54832	broad.mit.edu	37	chr15	62300907	62300907	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcttgtatttcctataaggCgcattcctaaccatataatc	6	10	0	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr15:62300907C>T	uc002agz.2	-	14	1139	c.1065G>A	c.(1063-1065)GCG>GCA	p.A355A	VPS13C_uc002aha.2_Silent_p.A312A|VPS13C_uc002ahb.1_Silent_p.A355A|VPS13C_uc002ahc.1_Silent_p.A312A	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	355					protein localization					ovary(2)	2						TCCTATAAGGCGCATTCCTAA	0.274													T	62300907	T	T	62300907	2	4	102	1	0	0	0	0	0	0	0	1	17188	755	27	1		1	VPS13C	15	62300907	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08	21549589	62300907	40230485	37	6991											
THSD4	79875	broad.mit.edu	37	chr15	72037463	72037463	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggatcgcagtaccctatttTccgctgtgtgcacagaagca	10	11	0	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr15:72037463T>C	uc002atb.1	+	11	2004	c.1925T>C	c.(1924-1926)TTC>TCC	p.F642S	THSD4_uc002ate.2_Missense_Mutation_p.F282S	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	642						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TACCCTATTTTCCGCTGTGTG	0.547													C	72037463	C	C	72037463	3	2	102	1	0	0	0	0	1	0	0	0	15875	1783	62	4	1967	4	THSD4	15	72037463	Missense_Mutation	SNP	T	TCGA-06-6693-01A-11D-1845-08	9736556	72037463	30493929	38	6992											
LRRK1	79705	broad.mit.edu	37	chr15	101569415	101569415	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctggccaagtttgagatcGccctgcccgtcgccaatgac	10	15	0	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr15:101569415G>A	uc002bwr.2	+	20	3260	c.2941G>A	c.(2941-2943)GCC>ACC	p.A981T	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	981					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTTTGAGATCGCCCTGCCCGT	0.592													A	101569415	A	A	101569415	3	1	102	1	0	0	0	0	1	0	0	0	9032	1087	38	1	3015	1	LRRK1	15	101569415	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	29531952	101569415	961977	39	6993											
SRL	6345	broad.mit.edu	37	chr16	4245578	4245578	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcttgctgcttgcggttctCgatgatgcctggtgtatcca	11	10	2	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr16:4245578C>T	uc002cvz.3	-	5	599	c.586G>A	c.(586-588)GAG>AAG	p.E196K	SRL_uc002cvy.3_RNA	NM_001098814	NP_001092284	Q86TD4	SRCA_HUMAN	sarcalumenin	655						sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5						TTGCGGTTCTCGATGATGCCT	0.378													T	4245578	T	T	4245578	3	4	102	1	0	0	0	0	1	0	0	0	15149	893	31	2	843	2	SRL	16	4245578	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08		4245578	86109175	40	6994											
CETP	1071	broad.mit.edu	37	chr16	57016107	57016107	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtccgtccagagcttcctgCagtcaatgatcaccgctgtg	10	13	2	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr16:57016107C>T	uc002eki.2	+	14	1336	c.1279C>T	c.(1279-1281)CAG>TAG	p.Q427*	CETP_uc002ekj.2_Nonsense_Mutation_p.Q367*	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	427					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						GAGCTTCCTGCAGTCAATGAT	0.582													T	57016107	T	T	57016107	4	4	102	1	0	0	0	0	0	1	0	0	3277	711	25	3	1333	3	CETP	16	57016107	Nonsense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08	52770529	57016107	33338646	41	6995											
GALNS	2588	broad.mit.edu	37	chr16	88891241	88891241	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtgctgcccgagggtggcCgccatcagcgtgtcgccacg	15	14	1	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr16:88891241C>T	uc002fly.3	-	11	1265	c.1176G>A	c.(1174-1176)GCG>GCA	p.A392A	GALNS_uc002flx.2_5'Flank|GALNS_uc010cid.2_Silent_p.A398A|GALNS_uc002flz.3_Silent_p.A75A	NM_000512	NP_000503	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	392			A -> V (in MPS4A).			lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			large_intestine(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	CGAGGGTGGCCGCCATCAGCG	0.627													T	88891241	T	T	88891241	2	4	102	1	0	0	0	0	0	0	0	1	6206	639	23	2		2	GALNS	16	88891241	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08	31875134	88891241	1463512	42	6996											
DNAH2	146754	broad.mit.edu	37	chr17	7644166	7644166	+	Frame_Shift_Del	DEL	C	-	-													gacaagaaggcggtggatctCtacatgctgttcaatagcga							TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr17:7644166delC	uc002giu.1	+	10	1559	c.1545delC	c.(1543-1545)CTCfs	p.L515fs	DNAH2_uc002git.2_Frame_Shift_Del_p.L597fs|DNAH2_uc010vuk.1_Frame_Shift_Del_p.L515fs	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	515	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CGGTGGATCTCTACATGCTGT	0.587													-	7644166	-	-	7644166	7	5	102	1	0	1	0	1	0	0	0	0	4602	900	32	0	1583	0	DNAH2	17	7644166	Frame_Shift_Del	DEL	C	TCGA-06-6693-01A-11D-1845-08		7644166	73551044	43	6997											
CRLF3	51379	broad.mit.edu	37	chr17	29119557	29119557	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtgctatatttcttcgactgCtcagactgtacccctcaaaa	6	12	3	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr17:29119557C>G	uc002hfr.3	-	6	969	c.860G>C	c.(859-861)AGC>ACC	p.S287T	CRLF3_uc010wbr.1_Missense_Mutation_p.S171T	NM_015986	NP_057070	Q8IUI8	CRLF3_HUMAN	cytokine receptor-like factor 3	287					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm					0		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				TCTTCGACTGCTCAGACTGTA	0.423													G	29119557	G	G	29119557	3	3	102	1	0	0	0	0	1	0	0	0	3888	797	28	5	480	5	CRLF3	17	29119557	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08	21475391	29119557	52075653	44	6998											
TMEM106A	113277	broad.mit.edu	37	chr17	41365143	41365143	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccaaaccagccattggcaGcaaggctgtcaactactcca	7	15	1	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr17:41365143G>A	uc002idn.1	+	3	320	c.83G>A	c.(82-84)AGC>AAC	p.S28N	TMEM106A_uc010why.1_Intron|TMEM106A_uc010cze.1_Missense_Mutation_p.S28N|TMEM106A_uc010whz.1_Missense_Mutation_p.S28N	NM_145041	NP_659478	Q96A25	T106A_HUMAN	transmembrane protein 106A	28						integral to membrane					0		Breast(137;0.0164)		BRCA - Breast invasive adenocarcinoma(366;0.0917)		GCCATTGGCAGCAAGGCTGTC	0.547													A	41365143	A	A	41365143	3	1	102	1	0	0	0	0	1	0	0	0	16017	971	34	3	85	3	TMEM106A	17	41365143	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	12245586	41365143	39830067	45	6999											
CSH2	1443	broad.mit.edu	37	chr17	61949661	61949661	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttgaggatctgcccagtcCggcggctgccgtcttccagc	13	15	2	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr17:61949661C>T	uc002jch.2	-	5	594	c.479G>A	c.(478-480)CGG>CAG	p.R160Q	CSH2_uc002jcg.2_Missense_Mutation_p.R65Q|CSH2_uc002jci.2_3'UTR|GH2_uc002jcj.2_Missense_Mutation_p.G159R|CSH2_uc002jck.2_Missense_Mutation_p.R160Q	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	160					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						CTGCCCAGTCCGGCGGCTGCC	0.547													T	61949661	T	T	61949661	3	4	102	1	0	0	0	0	1	0	0	0	3941	652	23	2	178	2	CSH2	17	61949661	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08	20584518	61949661	19245549	46	7000											
PDE4A	5141	broad.mit.edu	37	chr19	10561526	10561526	+	Frame_Shift_Del	DEL	C	-	-													agaaacgtgtcagcagttggCccgggagactctggaggagc							TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr19:10561526delC	uc002moj.2	+	6	800	c.692delC	c.(691-693)GCCfs	p.A231fs	PDE4A_uc002mok.2_Frame_Shift_Del_p.A205fs|PDE4A_uc002mol.2_Frame_Shift_Del_p.A170fs|PDE4A_uc002mom.2_5'Flank|PDE4A_uc002mon.2_5'Flank	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	231					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CAGCAGTTGGCCCGGGAGACT	0.612													-	10561526	-	-	10561526	7	5	102	1	0	1	0	1	0	0	0	0	11639	739	26	0	1101	0	PDE4A	19	10561526	Frame_Shift_Del	DEL	C	TCGA-06-6693-01A-11D-1845-08		10561526	48567457	47	7001											
FAM129C	199786	broad.mit.edu	37	chr19	17653014	17653014	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctaccgtgaggccgagcggAgccgggggcgcttggggcag	21	11	0	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr19:17653014A>G	uc010xpr.1	+	11	1471	c.1333A>G	c.(1333-1335)AGC>GGC	p.S445G	FAM129C_uc010xpq.1_Missense_Mutation_p.S445G|FAM129C_uc002ngy.3_Missense_Mutation_p.S171G|FAM129C_uc010xpu.1_Missense_Mutation_p.S171G|FAM129C_uc002ngz.3_RNA|FAM129C_uc010eaw.2_Missense_Mutation_p.S171G|FAM129C_uc002nhb.2_Missense_Mutation_p.S44G	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	445											0						GGCCGAGCGGAGCCGGGGGCG	0.612													G	17653014	G	G	17653014	3	3	102	1	0	0	0	0	1	0	0	0	5438	304	11	4	1375	4	FAM129C	19	17653014	Missense_Mutation	SNP	A	TCGA-06-6693-01A-11D-1845-08	7091488	17653014	41475969	48	7002											
ZNF208	7757	broad.mit.edu	37	chr19	22155056	22155056	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tactaaagactgacaaccagCtgaaggctttgccacattct	7	11	1	3			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr19:22155056C>T	uc002nqp.2	-	5	2629	c.2480G>A	c.(2479-2481)AGC>AAC	p.S827N	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGACAACCAGCTGAAGGCTTT	0.393													T	22155056	T	T	22155056	3	4	102	1	0	0	0	0	1	0	0	0	17763	797	28	3	1066	3	ZNF208	19	22155056	Missense_Mutation	SNP	C	TCGA-06-6693-01A-11D-1845-08	4502042	22155056	36973927	49	7003											
ZNF180	7733	broad.mit.edu	37	chr19	44981361	44981361	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taagtttatagctctgcctgAatgactttccacattgattg	7	8	1	3			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr19:44981361A>C	uc002ozf.3	-	5	1619	c.1337T>G	c.(1336-1338)TTC>TGC	p.F446C	ZNF180_uc002ozh.3_Missense_Mutation_p.F103C|ZNF180_uc002ozi.3_Missense_Mutation_p.F419C|ZNF180_uc002ozg.3_Missense_Mutation_p.F445C|ZNF180_uc010ejm.2_Missense_Mutation_p.F421C	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	446	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				GCTCTGCCTGAATGACTTTCC	0.393													C	44981361	C	C	44981361	3	2	102	1	0	0	0	0	1	0	0	0	17745	246	9	5	745	5	ZNF180	19	44981361	Missense_Mutation	SNP	A	TCGA-06-6693-01A-11D-1845-08	22826305	44981361	14147622	50	7004											
TMC2	117532	broad.mit.edu	37	chr20	2616589	2616589	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagcttggccatttactaccTgaactcagtttccaaaagcc	6	13	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr20:2616589T>A	uc002wgf.1	+	18	2339	c.2324T>A	c.(2323-2325)CTG>CAG	p.L775Q	TMC2_uc002wgg.1_Missense_Mutation_p.L759Q	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	775	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						ATTTACTACCTGAACTCAGTT	0.502													A	2616589	A	A	2616589	3	1	102	1	0	0	0	0	1	0	0	0	15982	1580	55	5	2394	5	TMC2	20	2616589	Missense_Mutation	SNP	T	TCGA-06-6693-01A-11D-1845-08		2616589	60408931	51	7005											
PLTP	5360	broad.mit.edu	37	chr20	44528299	44528299	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccccaatctgcagcatggtcTtcagaggggcctgtaatggg	13	11	3	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr20:44528299T>C	uc002xqn.1	-	14	1324	c.1244A>G	c.(1243-1245)AAG>AGG	p.K415R	PLTP_uc002xql.1_Missense_Mutation_p.K327R|PLTP_uc002xqm.1_Missense_Mutation_p.K435R|PLTP_uc002xqo.1_Missense_Mutation_p.K363R|PLTP_uc002xqp.1_Missense_Mutation_p.K410R|PLTP_uc002xqq.1_Missense_Mutation_p.K384R|PLTP_uc010zxj.1_Missense_Mutation_p.K320R|PLTP_uc010ghj.1_Intron	NM_006227	NP_006218	P55058	PLTP_HUMAN	phospholipid transfer protein isoform a	415					cellular lipid metabolic process|lipid transport	extracellular region	lipid binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CAGCATGGTCTTCAGAGGGGC	0.602													C	44528299	C	C	44528299	3	2	102	1	0	0	0	0	1	0	0	0	12114	1609	56	4	249	4	PLTP	20	44528299	Missense_Mutation	SNP	T	TCGA-06-6693-01A-11D-1845-08	41911710	44528299	18497221	52	7006											
ZGPAT	84619	broad.mit.edu	37	chr20	62367145	62367145	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccgcaggcatagcgtggcGtcagcccagctgcaggagaa	14	13	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr20:62367145G>A	uc002ygk.2	+	7	1648	c.1470G>A	c.(1468-1470)GCG>GCA	p.A490A	ZGPAT_uc002ygi.2_Silent_p.A470A|ZGPAT_uc002ygj.2_Silent_p.A470A|ZGPAT_uc010gkk.1_Silent_p.A47A|ZGPAT_uc010gkl.1_Silent_p.A470A|ZGPAT_uc002ygm.2_Silent_p.A461A|ZGPAT_uc002ygn.3_RNA|LIME1_uc011abi.1_5'UTR|LIME1_uc002ygp.3_5'Flank	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	490					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					ATAGCGTGGCGTCAGCCCAGC	0.692													A	62367145	A	A	62367145	2	1	102	1	0	0	0	0	0	0	0	1	17671	1132	40	1		1	ZGPAT	20	62367145	Silent	SNP	G	TCGA-06-6693-01A-11D-1845-08	17838846	62367145	658375	53	7007											
UMODL1	89766	broad.mit.edu	37	chr21	43524008	43524008	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ccttcccaccagtggtgtctGacttgtaccgaagtgggaag	12	11	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr21:43524008G>C	uc002zaf.1	+	9	1330	c.1330G>C	c.(1330-1332)GAC>CAC	p.D444H	UMODL1_uc002zad.1_Missense_Mutation_p.D372H|UMODL1_uc002zae.1_Missense_Mutation_p.D372H|UMODL1_uc002zag.1_Missense_Mutation_p.D444H|UMODL1_uc010gow.1_Missense_Mutation_p.D236H|UMODL1_uc002zai.1_Missense_Mutation_p.D95H|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Missense_Mutation_p.D95H|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.D189H|C21orf128_uc002zak.2_Silent_p.V75V	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	444	Extracellular (Potential).|SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						AGTGGTGTCTGACTTGTACCG	0.567													C	43524008	C	C	43524008	3	2	102	1	0	0	0	0	1	0	0	0	16977	1290	45	5	1364	5	UMODL1	21	43524008	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08		43524008	4605887	54	7008											
UMODL1	89766	broad.mit.edu	37	chr21	43524114	43524114	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggaccccgggtttcccatggGcatctccacgctggccccca	11	18	1	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr21:43524114G>C	uc002zaf.1	+	9	1436	c.1436G>C	c.(1435-1437)GGC>GCC	p.G479A	UMODL1_uc002zad.1_Missense_Mutation_p.G407A|UMODL1_uc002zae.1_Missense_Mutation_p.G407A|UMODL1_uc002zag.1_Missense_Mutation_p.G479A|UMODL1_uc010gow.1_Missense_Mutation_p.G271A|UMODL1_uc002zai.1_Missense_Mutation_p.G130A|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Missense_Mutation_p.G130A|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.G224A|C21orf128_uc002zak.2_Missense_Mutation_p.A40G	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	479	Extracellular (Potential).|SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TTTCCCATGGGCATCTCCACG	0.622													C	43524114	C	C	43524114	3	2	102	1	0	0	0	0	1	0	0	0	16977	1203	42	5	1470	5	UMODL1	21	43524114	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	106	43524114	4605781	55	7009											
TRPM2	7226	broad.mit.edu	37	chr21	45817635	45817635	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcctctggtccccagagccaGgactgcatcgcagcggcctt	11	16	1	1			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chr21:45817635G>C	uc002zet.1	+	14	2151	c.1938G>C	c.(1936-1938)CAG>CAC	p.Q646H	TRPM2_uc002zeu.1_Missense_Mutation_p.Q646H|TRPM2_uc002zew.1_Missense_Mutation_p.Q646H|TRPM2_uc010gpt.1_Missense_Mutation_p.Q646H|TRPM2_uc002zex.1_Missense_Mutation_p.Q432H|TRPM2_uc002zey.1_Missense_Mutation_p.Q159H	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	646	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCCAGAGCCAGGACTGCATCG	0.627													C	45817635	C	C	45817635	3	2	102	1	0	0	0	0	1	0	0	0	16583	991	35	5	1988	5	TRPM2	21	45817635	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	2293521	45817635	2312260	56	7010											
PHEX	5251	broad.mit.edu	37	chrX	22132590	22132590	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccacaggtaatccaggggacCacaactttgctgcctcaatg	9	13	1	0			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chrX:22132590C>G	uc004dah.2	+	11	1391	c.1188C>G	c.(1186-1188)ACC>ACG	p.T396T	PHEX_uc011mjr.1_Silent_p.T396T|PHEX_uc011mjs.1_Silent_p.T299T	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	396	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						TCCAGGGGACCACAACTTTGC	0.398													G	22132590	G	G	22132590	2	3	102	1	0	0	0	0	0	0	0	1	11819	581	21	5		5	PHEX	23	22132590	Silent	SNP	C	TCGA-06-6693-01A-11D-1845-08		22132590	133137970	57	7011											
DCAF8L1	139425	broad.mit.edu	37	chrX	27999308	27999308	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggtatcaccaccatctccGgtcgatggctctgtggctgc	11	14	3	0	rs147579544	byFrequency	TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chrX:27999308G>A	uc004dbx.1	-	1	259	c.144C>T	c.(142-144)ACC>ACT	p.T48T		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	48										ovary(3)|skin(1)	4						CACCATCTCCGGTCGATGGCT	0.532													A	27999308	A	A	27999308	2	1	102	1	0	0	0	0	0	0	0	1	4277	1103	39	2		2	DCAF8L1	23	27999308	Silent	SNP	G	TCGA-06-6693-01A-11D-1845-08	5866718	27999308	127271252	58	7012											
MAGEB16	139604	broad.mit.edu	37	chrX	35821053	35821053	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cttcatctttggagagcccaGaatgctcatcaccaaagatt	7	11	4	3			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chrX:35821053G>A	uc010ngt.1	+	2	1019	c.740G>A	c.(739-741)AGA>AAA	p.R247K		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	247	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						GGAGAGCCCAGAATGCTCATC	0.493													A	35821053	A	A	35821053	3	1	102	1	0	0	0	0	1	0	0	0	9174	942	33	3	742	3	MAGEB16	23	35821053	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	7821745	35821053	119449507	59	7013											
GPR82	27197	broad.mit.edu	37	chrX	41587247	41587247	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caagaagacactatataatcTctttacaaagtctaattcag	4	8	3	2	rs144887525		TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chrX:41587247T>G	uc004dfs.1	+	3	1208	c.968T>G	c.(967-969)CTC>CGC	p.L323R	CASK_uc004dfl.3_Intron|CASK_uc004dfm.3_Intron|CASK_uc004dfn.3_Intron|GPR82_uc004dft.2_Missense_Mutation_p.L323R|GPR82_uc004dfu.1_RNA	NM_080817	NP_543007	Q96P67	GPR82_HUMAN	G protein-coupled receptor 82	323	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						CTATATAATCTCTTTACAAAG	0.333													G	41587247	G	G	41587247	3	3	102	1	0	0	0	0	1	0	0	0	6712	1551	54	5	970	5	GPR82	23	41587247	Missense_Mutation	SNP	T	TCGA-06-6693-01A-11D-1845-08	5766194	41587247	113683313	60	7014											
MAGIX	79917	broad.mit.edu	37	chrX	49021421	49021421	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccagcacagcgctgtggtcGtttggaggtgagccctgaag	15	11	0	2			TCGA-06-6693-01A-11D-1845-08	TCGA-06-6693-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45ca8f53-6d0e-4659-a81f-258184b7a70e	244e9dd6-f856-48eb-8288-66cad9fd3ea2	g.chrX:49021421G>A	uc010nin.1	+	4	547	c.500G>A	c.(499-501)CGT>CAT	p.R167H	MAGIX_uc010nio.1_Intron|MAGIX_uc004dmt.2_Intron|MAGIX_uc004dmu.2_Missense_Mutation_p.R108H|MAGIX_uc004dmw.2_Missense_Mutation_p.R100H	NM_024859	NP_079135	Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked isoform a	167	PDZ.										0						CGCTGTGGTCGTTTGGAGGTG	0.622													A	49021421	A	A	49021421	3	1	102	1	0	0	0	0	1	0	0	0	9193	1145	40	1	554	1	MAGIX	23	49021421	Missense_Mutation	SNP	G	TCGA-06-6693-01A-11D-1845-08	7434174	49021421	106249139	61	7015											
TNFRSF8	943	broad.mit.edu	37	chr1	12172043	12172043	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacctggacgaggccggccgCtgcacggcctgcgtgagctg	16	14	0	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:12172043C>T	uc001atq.2	+	7	987	c.765C>T	c.(763-765)CGC>CGT	p.R255R	TNFRSF8_uc010obc.1_Silent_p.R144R	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	255	TNFR-Cys 5.|Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		AGGCCGGCCGCTGCACGGCCT	0.587													T	12172043	T	T	12172043	2	4	103	1	0	0	0	0	0	0	0	1	16296	784	28	3		3	TNFRSF8	1	12172043	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08		12172043	237078578	1	7016											
LOC440563	440563	broad.mit.edu	37	chr1	13183578	13183578	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtacatctccgctgcggatcGtttcacacctgcgtttcctc	8	15	2	0	rs115194400	by1000genomes	TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:13183578G>A	uc010obg.1	-	1	390	c.295C>T	c.(295-297)CGA>TGA	p.R99*		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	99						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						GCTGCGGATCGTTTCACACCT	0.502													A	13183578	A	A	13183578	4	1	103	1	0	0	0	0	0	1	0	0	8879	1153	40	1	590	1	LOC440563	1	13183578	Nonsense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	1011535	13183578	236067043	2	7017											
EPHA10	284656	broad.mit.edu	37	chr1	38227194	38227194	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggggctgccaggctccccttCcgagtgcgccacgcacgttc	13	17	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:38227194C>T	uc009vvi.2	-	3	819	c.733G>A	c.(733-735)GAA>AAA	p.E245K	EPHA10_uc001cbw.3_Missense_Mutation_p.E245K	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	245	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGCTCCCCTTCCGAGTGCGCC	0.736													T	38227194	T	T	38227194	3	4	103	1	0	0	0	0	1	0	0	0	5166	864	30	3	2391	3	EPHA10	1	38227194	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	25043616	38227194	211023427	3	7018											
MACF1	23499	broad.mit.edu	37	chr1	39924911	39924911	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgaatgatgccttggatcGgctggaggaggtaatgccct	14	8	0	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:39924911G>A	uc010oiu.1	+	56	16810	c.16679G>A	c.(16678-16680)CGG>CAG	p.R5560Q	MACF1_uc010ois.1_Missense_Mutation_p.R5058Q|MACF1_uc001cde.1_5'Flank|MACF1_uc001cdf.1_5'Flank	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7016					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCCTTGGATCGGCTGGAGGAG	0.512													A	39924911	A	A	39924911	3	1	103	1	0	0	0	0	1	0	0	0	9144	1116	39	2	21670	2	MACF1	1	39924911	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	1697717	39924911	209325710	4	7019											
KIAA0467	23334	broad.mit.edu	37	chr1	43912755	43912755	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccatctggtgctgcggcacGgctaccacctcaccaccttt	8	18	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:43912755G>A	uc001cjk.1	+	51	6967	c.6505G>A	c.(6505-6507)GGC>AGC	p.G2169S	KIAA0467_uc001cjl.1_Missense_Mutation_p.G157S	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	3068						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCTGCGGCACGGCTACCACCT	0.607													A	43912755	A	A	43912755	3	1	103	1	0	0	0	0	1	0	0	0	8178	1116	39	2	6699	2	KIAA0467	1	43912755	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	3987844	43912755	205337866	5	7020											
JUN	3725	broad.mit.edu	37	chr1	59248392	59248392	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctgtgcagttcggccagGgcgcgcacgaagccctcggc	16	14	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:59248392G>A	uc001cze.2	-	1	1394	c.351C>T	c.(349-351)GCC>GCT	p.A117A	uc001czf.2_5'Flank|uc010oop.1_5'Flank	NM_002228	NP_002219	P05412	JUN_HUMAN	jun oncogene	117					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation by host of viral transcription|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein import into nucleus|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway		R-SMAD binding|Rho GTPase activator activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity|transcription factor binding|transcription regulatory region DNA binding				0	all_cancers(7;8.55e-07)				Arsenic trioxide(DB01169)|Irbesartan(DB01029)|Vinblastine(DB00570)	GTTCGGCCAGGGCGCGCACGA	0.697			A		sarcoma								A	59248392	A	A	59248392	2	1	103	1	0	0	0	0	0	0	0	1	7969	1219	43	3		3	JUN	1	59248392	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	15335637	59248392	190002229	6	7021											
CTSS	1520	broad.mit.edu	37	chr1	150730364	150730364	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtggttcatgcccagatcGtatgagtgcattcccattga	11	9	1	3	rs139535421		TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:150730364G>A	uc001evn.2	-	3	352	c.219C>T	c.(217-219)TAC>TAT	p.Y73Y	CTSS_uc010pcj.1_Silent_p.Y73Y|CTSS_uc001evo.1_Silent_p.Y73Y	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	73					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			TGCCCAGATCGTATGAGTGCA	0.428													A	150730364	A	A	150730364	2	1	103	1	0	0	0	0	0	0	0	1	4041	1140	40	1		1	CTSS	1	150730364	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	91481972	150730364	98520257	7	7022											
FLG	2312	broad.mit.edu	37	chr1	152285059	152285059	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctctgctgatggtgaccaGcctgtccatggcctgacact	12	13	1	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:152285059G>A	uc001ezu.1	-	3	2339	c.2303C>T	c.(2302-2304)GCT>GTT	p.A768V	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	768	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGTGACCAGCCTGTCCATG	0.562									Ichthyosis				A	152285059	A	A	152285059	3	1	103	1	0	0	0	0	1	0	0	0	5922	971	34	3	9886	3	FLG	1	152285059	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	1554695	152285059	96965562	8	7023											
NUF2	83540	broad.mit.edu	37	chr1	163315530	163315530	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gactgcctgccttcatgtcaGttggaagtgcagttatatca	10	9	3	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:163315530G>T	uc001gcq.1	+	11	1170	c.870G>T	c.(868-870)CAG>CAT	p.Q290H	NUF2_uc001gcp.2_Missense_Mutation_p.Q290H|NUF2_uc001gcr.1_Missense_Mutation_p.Q290H|NUF2_uc009wvc.1_Intron	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	290	Interaction with the N-terminus of NDC80.|Potential.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					CTTCATGTCAGTTGGAAGTGC	0.358													T	163315530	T	T	163315530	3	4	103	1	0	0	0	0	1	0	0	0	10747	1020	36	5	908	5	NUF2	1	163315530	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	11030471	163315530	85935091	9	7024											
HMCN1	83872	broad.mit.edu	37	chr1	186092310	186092310	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacgtgcatggcagccaatGtagcaggatcaagcagcaca	11	11	1	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:186092310G>A	uc001grq.1	+	81	12686	c.12457G>A	c.(12457-12459)GTA>ATA	p.V4153I		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4153	Ig-like C2-type 40.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GGCAGCCAATGTAGCAGGATC	0.498													A	186092310	A	A	186092310	3	1	103	1	0	0	0	0	1	0	0	0	7220	1377	48	3	12779	3	HMCN1	1	186092310	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	22776780	186092310	63158311	10	7025											
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200823985	200823985	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgctgaacacgggtgataaCgagagtgtacattcaggcaa	12	8	1	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:200823985C>T	uc001gvl.2	+	15	4167	c.3897C>T	c.(3895-3897)AAC>AAT	p.N1299N	CAMSAP1L1_uc001gvk.2_Silent_p.N1288N|CAMSAP1L1_uc001gvm.2_Silent_p.N1272N	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1299						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CGGGTGATAACGAGAGTGTAC	0.343													T	200823985	T	T	200823985	2	4	103	1	0	0	0	0	0	0	0	1	2612	535	19	1		1	CAMSAP1L1	1	200823985	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	14731675	200823985	48426636	11	7026											
CHML	1122	broad.mit.edu	37	chr1	241797187	241797187	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tactacattattggttccagGagcctctggctgcttatcat	8	10	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr1:241797187G>A	uc001hzd.2	-	1	2046	c.1882C>T	c.(1882-1884)CCT>TCT	p.P628S	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	628					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity	p.P628S(1)		ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TTGGTTCCAGGAGCCTCTGGC	0.418													A	241797187	A	A	241797187	3	1	103	1	0	0	0	0	1	0	0	0	3351	1174	41	3	92	3	CHML	1	241797187	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	40973202	241797187	7453434	12	7027											
FBLN7	129804	broad.mit.edu	37	chr2	112944813	112944813	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgccttccaacctgaagacGcccatcacgctcttccgcat	6	18	2	2	rs140504449		TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr2:112944813G>A	uc002tho.1	+	8	1321	c.1050G>A	c.(1048-1050)ACG>ACA	p.T350T	FBLN7_uc002thn.2_Intron|FBLN7_uc010fki.1_Silent_p.T304T|FBLN7_uc010fkj.1_Silent_p.T216T	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	350					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						ACCTGAAGACGCCCATCACGC	0.652													A	112944813	A	A	112944813	2	1	103	1	0	0	0	0	0	0	0	1	5701	1074	38	1		1	FBLN7	2	112944813	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08		112944813	130254560	13	7028											
XIRP2	129446	broad.mit.edu	37	chr2	168103045	168103045	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taataggtggtgatgtcaaaCgtaccattcataatttattg	8	5	2	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr2:168103045C>T	uc002udx.2	+	8	5161	c.5143C>T	c.(5143-5145)CGT>TGT	p.R1715C	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R1540C|XIRP2_uc010fpq.2_Missense_Mutation_p.R1493C|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1540					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TGATGTCAAACGTACCATTCA	0.338													T	168103045	T	T	168103045	3	4	103	1	0	0	0	0	1	0	0	0	17427	536	19	1	5173	1	XIRP2	2	168103045	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	55158232	168103045	75096328	14	7029											
ABCB11	8647	broad.mit.edu	37	chr2	169814525	169814525	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aagggtgtgactgtcccgttCacagctgcacccacagaccc	10	15	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr2:169814525C>T	uc002ueo.1	-	19	2418	c.2292G>A	c.(2290-2292)GTG>GTA	p.V764V	ABCB11_uc010zda.1_Silent_p.V206V|ABCB11_uc010zdb.1_Silent_p.V240V	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	764	Helical; (Potential).|ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTGTCCCGTTCACAGCTGCAC	0.473													T	169814525	T	T	169814525	2	4	103	1	0	0	0	0	0	0	0	1	42	813	29	3		3	ABCB11	2	169814525	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	1711480	169814525	73384848	15	7030											
TRAK2	66008	broad.mit.edu	37	chr2	202272228	202272229	+	Frame_Shift_Del	DEL	AG	-	-													gtcttgattttcatatagaaAgagagtgtctacttttagcc							TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr2:202272228_202272229delAG	uc002uyb.3	-	3	629_630	c.183_184delCT	c.(181-186)CTCTTTfs	p.L61fs	TRAK2_uc002uyc.2_Frame_Shift_Del_p.L61fs	NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	61_62						early endosome|plasma membrane	GABA receptor binding				0						TCATATAGAAAGAGAGTGTCTA	0.46													-	202272229	-	-	202272228	7	5	103	1	0	1	0	1	0	0	0	0	16447	72	3	0	2616	0	TRAK2	2	202272228	Frame_Shift_Del	DEL	AG	TCGA-06-6694-01A-12D-1845-08	32457703	202272228	40927145	16	7031											
DES	1674	broad.mit.edu	37	chr2	220286194	220286194	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgagatggcccgccatctgCgcgagtaccaggacctgctc	12	14	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr2:220286194C>T	uc002vll.2	+	6	1242	c.1156C>T	c.(1156-1158)CGC>TGC	p.R386C		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	386	Rod.|Coil 2B.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		CCGCCATCTGCGCGAGTACCA	0.622													T	220286194	T	T	220286194	3	4	103	1	0	0	0	0	1	0	0	0	4449	768	27	1	1178	1	DES	2	220286194	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	18013966	220286194	22913179	17	7032											
SETD5	55209	broad.mit.edu	37	chr3	9489393	9489393	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	attgctgcagaaaaactagtCcccaagccacctccagcaaa	6	14	0	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr3:9489393C>T	uc003brt.2	+	15	2241	c.1806C>T	c.(1804-1806)GTC>GTT	p.V602V	SETD5_uc003brs.1_Silent_p.V583V|SETD5_uc003bru.2_Silent_p.V504V|SETD5_uc003brv.2_Silent_p.V491V|SETD5_uc010hck.2_Silent_p.V84V|SETD5_uc003brx.2_Silent_p.V271V	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	602										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AAAAACTAGTCCCCAAGCCAC	0.468													T	9489393	T	T	9489393	2	4	103	1	0	0	0	0	0	0	0	1	14134	842	30	3		3	SETD5	3	9489393	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08		9489393	188533037	18	7033											
FAM19A4	151647	broad.mit.edu	37	chr3	68929927	68929927	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaggcggacatcagcttacaGcacaccattaacacgtaggc	10	12	1	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr3:68929927G>T	uc003dnh.1	-	3	527	c.84C>A	c.(82-84)TGC>TGA	p.C28*	FAM19A4_uc003dni.1_Nonsense_Mutation_p.C28*	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine	28						extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		TCAGCTTACAGCACACCATTA	0.512													T	68929927	T	T	68929927	4	4	103	1	0	0	0	0	0	1	0	0	5534	963	34	5	354	5	FAM19A4	3	68929927	Nonsense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	59440534	68929927	129092503	19	7034											
CEP97	79598	broad.mit.edu	37	chr3	101476715	101476715	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atcacctacagttgagctgaGgctgcagggcattaacttgg	12	9	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr3:101476715G>T	uc003dvk.1	+	9	1292	c.1265G>T	c.(1264-1266)AGG>ATG	p.R422M	CEP97_uc010hpm.1_Missense_Mutation_p.R388M|CEP97_uc011bhf.1_Missense_Mutation_p.R363M|CEP97_uc003dvl.1_Missense_Mutation_p.R118M|CEP97_uc003dvm.1_Missense_Mutation_p.R260M	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	422	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						GTTGAGCTGAGGCTGCAGGGC	0.473													T	101476715	T	T	101476715	3	4	103	1	0	0	0	0	1	0	0	0	3263	1000	35	5	1299	5	CEP97	3	101476715	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	32546788	101476715	96545715	20	7035											
SPON2	10417	broad.mit.edu	37	chr4	1165082	1165082	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgcgctgcacctccagctccGccgacgtctgcccggtgccg	12	19	1	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr4:1165082G>T	uc003gcn.3	-	2	440	c.413C>A	c.(412-414)GCG>GAG	p.A138E	SPON2_uc003gco.3_Missense_Mutation_p.A138E|SPON2_uc010ibr.2_Missense_Mutation_p.A138E|SPON2_uc003gcm.1_Missense_Mutation_p.A56E	NM_012445	NP_036577	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	138	Spondin.				axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding	p.A138A(1)		central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		CTCCAGCTCCGCCGACGTCTG	0.552													T	1165082	T	T	1165082	3	4	103	1	0	0	0	0	1	0	0	0	15082	1087	38	5	598	5	SPON2	4	1165082	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08		1165082	189989194	21	7036											
HELQ	113510	broad.mit.edu	37	chr4	84368060	84368060	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagttcaccaagctatgtccTttttcaatagtggcaatata	7	8	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr4:84368060T>C	uc003hom.2	-	4	1499	c.1320A>G	c.(1318-1320)AAA>AAG	p.K440K	HELQ_uc010ikb.2_Intron|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	440	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						AGCTATGTCCTTTTTCAATAG	0.373								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					C	84368060	C	C	84368060	2	2	103	1	0	0	0	0	0	0	0	1	7047	1606	56	4		4	HELQ	4	84368060	Silent	SNP	T	TCGA-06-6694-01A-12D-1845-08	83202978	84368060	106786216	22	7037											
BMPR1B	658	broad.mit.edu	37	chr4	96075770	96075770	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcatcaaggctgacagccctGcgggttaagaaaacacttgc	11	11	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr4:96075770G>C	uc003htm.3	+	13	1729	c.1455G>C	c.(1453-1455)CTG>CTC	p.L485L	BMPR1B_uc010ilb.2_Silent_p.L485L|BMPR1B_uc003htn.3_Silent_p.L485L	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	485	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		TGACAGCCCTGCGGGTTAAGA	0.448													C	96075770	C	C	96075770	2	2	103	1	0	0	0	0	0	0	0	1	1470	1306	46	5		5	BMPR1B	4	96075770	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	11707710	96075770	95078506	23	7038											
DKK2	27123	broad.mit.edu	37	chr4	107845338	107845338	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaatgcagtctgatgatcGtaggcaggggtctccttcat	11	9	4	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr4:107845338G>A	uc003hyi.2	-	4	1258	c.553C>T	c.(553-555)CGA>TGA	p.R185*	DKK2_uc003hyj.1_3'UTR	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	185	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		TCTGATGATCGTAGGCAGGGG	0.448													A	107845338	A	A	107845338	4	1	103	1	0	0	0	0	0	1	0	0	4545	1153	40	1	230	1	DKK2	4	107845338	Nonsense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	11769568	107845338	83308938	24	7039											
ZFR	51663	broad.mit.edu	37	chr5	32390482	32390482	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tccatctggcattcggcggcGatcatcccaatgatgttgtt	10	11	2	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr5:32390482G>A	uc003jhr.1	-	12	2121	c.2041C>T	c.(2041-2043)CGC>TGC	p.R681C	ZFR_uc011cny.1_5'Flank	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	681					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		ATTCGGCGGCGATCATCCCAA	0.507													A	32390482	A	A	32390482	3	1	103	1	0	0	0	0	1	0	0	0	17656	1058	37	2	1219	2	ZFR	5	32390482	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08		32390482	148524778	25	7040											
CARTPT	9607	broad.mit.edu	37	chr5	71015195	71015195	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgctacctctgttgggtacCcgtgcccaggaggacgccga	13	13	1	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr5:71015195C>T	uc003kbv.1	+	1	202	c.75C>T	c.(73-75)ACC>ACT	p.T25T		NM_004291	NP_004282	Q16568	CART_HUMAN	cocaine- and amphetamine-regulated transcript	25					activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				ovary(1)	1		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)	TGTTGGGTACCCGTGCCCAGG	0.657													T	71015195	T	T	71015195	2	4	103	1	0	0	0	0	0	0	0	1	2659	610	22	3		3	CARTPT	5	71015195	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	38624713	71015195	109900065	26	7041											
GCNT4	51301	broad.mit.edu	37	chr5	74325583	74325583	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	atcctccaagtcaatgatgtCccttcttcttatttccagac	4	13	3	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr5:74325583C>A	uc003kdn.2	-	1	1142	c.280G>T	c.(280-282)GAC>TAC	p.D94Y		NM_016591	NP_057675	Q9P109	GCNT4_HUMAN	core 2 beta-1,6-N-acetylglucosaminyltransferase	94	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		TCAATGATGTCCCTTCTTCTT	0.403													A	74325583	A	A	74325583	3	1	103	1	0	0	0	0	1	0	0	0	6303	855	30	5	1085	5	GCNT4	5	74325583	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	3310388	74325583	106589677	27	7042											
SLC36A2	153201	broad.mit.edu	37	chr5	150704898	150704898	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttgatgtcatctccaaacCgcaggtagcccagagccgcc	9	16	2	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr5:150704898C>T	uc003lty.2	-	8	1089	c.959G>A	c.(958-960)CGG>CAG	p.R320Q	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Missense_Mutation_p.R122Q|SLC36A2_uc010jhv.2_Missense_Mutation_p.R320Q	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	320	Extracellular (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCTCCAAACCGCAGGTAGCC	0.488													T	150704898	T	T	150704898	3	4	103	1	0	0	0	0	1	0	0	0	14594	652	23	2	504	2	SLC36A2	5	150704898	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	76379315	150704898	30210362	28	7043											
IL12B	3593	broad.mit.edu	37	chr5	158743808	158743808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtggctgaggtcttgtccGtgaagactctatctttctgc	11	11	4	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr5:158743808G>A	uc003lxr.1	-	7	914	c.872C>T	c.(871-873)ACG>ATG	p.T291M		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	291	Fibronectin type-III.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGTCTTGTCCGTGAAGACTCT	0.512											OREG0016989	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	158743808	A	A	158743808	3	1	103	1	0	0	0	0	1	0	0	0	7625	1145	40	1	118	1	IL12B	5	158743808	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	8038910	158743808	22171452	29	7044											
FOXF2	2295	broad.mit.edu	37	chr6	1391312	1391312	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catgtcctcctactcgctggAgcagagctacttgcaccaga	9	14	0	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr6:1391312A>G	uc003mtm.2	+	1	1244	c.1130A>G	c.(1129-1131)GAG>GGG	p.E377G	FOXF2_uc003mtn.2_Missense_Mutation_p.E377G	NM_001452	NP_001443	Q12947	FOXF2_HUMAN	forkhead box F2	377					epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		TACTCGCTGGAGCAGAGCTAC	0.682													G	1391312	G	G	1391312	3	3	103	1	0	0	0	0	1	0	0	0	6006	304	11	4	1132	4	FOXF2	6	1391312	Missense_Mutation	SNP	A	TCGA-06-6694-01A-12D-1845-08		1391312	169723755	30	7045											
TFAP2A	7020	broad.mit.edu	37	chr6	10410393	10410393	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtaggggtcgttgacgtggGagtaaggatcttgcgactgg	18	5	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr6:10410393G>A	uc003myr.2	-	2	473	c.221C>T	c.(220-222)TCC>TTC	p.S74F	TFAP2A_uc003myq.2_Missense_Mutation_p.S68F|TFAP2A_uc003mys.2_Intron|TFAP2A_uc011dih.1_Missense_Mutation_p.S74F|TFAP2A_uc003myt.2_Missense_Mutation_p.S70F|TFAP2A_uc003myu.1_Missense_Mutation_p.S74F|TFAP2A_uc003myv.1_Missense_Mutation_p.S60F|TFAP2A_uc011dii.1_Missense_Mutation_p.S70F|uc003myw.2_5'Flank	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	74	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				GTTGACGTGGGAGTAAGGATC	0.682													A	10410393	A	A	10410393	3	1	103	1	0	0	0	0	1	0	0	0	15784	1174	41	3	1116	3	TFAP2A	6	10410393	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	9019081	10410393	160704674	31	7046											
BAI3	577	broad.mit.edu	37	chr6	70042889	70042889	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcctagataaaaagctcaaAcacagagccgggtaagctgc	9	10	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr6:70042889A>G	uc003pev.3	+	24	3625	c.3177A>G	c.(3175-3177)AAA>AAG	p.K1059K	BAI3_uc010kak.2_Silent_p.K1059K|BAI3_uc011dxx.1_Silent_p.K265K|BAI3_uc003pex.1_Silent_p.K189K	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1059	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AAAAGCTCAAACACAGAGCCG	0.398													G	70042889	G	G	70042889	2	3	103	1	0	0	0	0	0	0	0	1	1300	40	2	4		4	BAI3	6	70042889	Silent	SNP	A	TCGA-06-6694-01A-12D-1845-08	59632496	70042889	101072178	32	7047											
CDK19	23097	broad.mit.edu	37	chr6	110959910	110959910	+	Splice_Site	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	actaggatatttgctggtttCtagaaataaaaatagagcat	8	4	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr6:110959910C>T	uc003puh.1	-	5	530	c.457_splice	c.e5-1	p.K153_splice	CDK19_uc003pui.1_Splice_Site_p.K93_splice|CDK19_uc011eax.1_Splice_Site_p.K29_splice	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)								ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TTGCTGGTTTCTAGAAATAAA	0.289													T	110959910	T	T	110959910	5	4	103	1	0	0	0	0	0	0	1	0	3135	927	32	3	1088	3	CDK19	6	110959910	Splice_Site	SNP	C	TCGA-06-6694-01A-12D-1845-08	40917021	110959910	60155157	33	7048											
C6orf170	221322	broad.mit.edu	37	chr6	121560260	121560260	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atccactggagtagttctggGatgggttaccctaacatcat	10	9	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr6:121560260G>A	uc003pyo.1	-	20	2388	c.2320C>T	c.(2320-2322)CCC>TCC	p.P774S	C6orf170_uc003pyq.1_RNA|C6orf170_uc010kej.1_5'Flank|C6orf170_uc003pyp.1_Missense_Mutation_p.P293S	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	774					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		GTAGTTCTGGGATGGGTTACC	0.333													A	121560260	A	A	121560260	3	1	103	1	0	0	0	0	1	0	0	0	2344	1174	41	3	1505	3	C6orf170	6	121560260	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	10600350	121560260	49554807	34	7049											
LPA	4018	broad.mit.edu	37	chr6	160998167	160998167	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggttttaatcaaatacataCgcatttgggtagttttctgg	9	5	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr6:160998167C>T	uc003qtl.2	-	29	4751	c.4631_splice	c.e29+1	p.A1544_splice		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor						blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CAAATACATACGCATTTGGGT	0.433													T	160998167	T	T	160998167	5	4	103	1	0	0	0	0	0	0	1	0	8903	550	19	1	1538	1	LPA	6	160998167	Splice_Site	SNP	C	TCGA-06-6694-01A-12D-1845-08	39437907	160998167	10116900	35	7050											
SLC29A4	222962	broad.mit.edu	37	chr7	5331368	5331368	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcctttttatcagcatctgcGacgtgtggctgcagctcttc	9	12	3	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr7:5331368G>A	uc003sod.2	+	5	621	c.460G>A	c.(460-462)GAC>AAC	p.D154N	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Missense_Mutation_p.D154N|SLC29A4_uc003soe.2_Silent_p.A141A	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	154	Helical; (Potential).			D->A: Loss of cationic transport activity; increase in uridine uptake.	nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		CAGCATCTGCGACGTGTGGCT	0.647													A	5331368	A	A	5331368	3	1	103	1	0	0	0	0	1	0	0	0	14537	1058	37	2	474	2	SLC29A4	7	5331368	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08		5331368	153807295	36	7051											
GRM3	2913	broad.mit.edu	37	chr7	86468659	86468659	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacacccttggtcaaagcatCgggccgagaactctgctaca	9	14	2	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr7:86468659C>T	uc003uid.2	+	4	2928	c.1829C>T	c.(1828-1830)TCG>TTG	p.S610L	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.S482L|GRM3_uc010leh.2_Missense_Mutation_p.S202L	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	610	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane		p.S610L(1)		lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GTCAAAGCATCGGGCCGAGAA	0.468													T	86468659	T	T	86468659	3	4	103	1	0	0	0	0	1	0	0	0	6798	893	31	2	1839	2	GRM3	7	86468659	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	81137291	86468659	72670004	37	7052											
TECPR1	25851	broad.mit.edu	37	chr7	97858368	97858368	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caccttggaagcagccgcctCcatagccgcctgtgtatacc	9	16	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr7:97858368C>T	uc003upg.2	-	16	2598	c.2393G>A	c.(2392-2394)GGA>GAA	p.G798E	TECPR1_uc003uph.1_Missense_Mutation_p.G728E	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	798						integral to membrane	protein binding			pancreas(1)	1						GCAGCCGCCTCCATAGCCGCC	0.677													T	97858368	T	T	97858368	3	4	103	1	0	0	0	0	1	0	0	0	15740	855	30	3	1148	3	TECPR1	7	97858368	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	11389709	97858368	61280295	38	7053											
CYP3A4	1576	broad.mit.edu	37	chr7	99359709	99359709	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtccagtactttgggtcaCggtgaagagcatagcttgga	13	8	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr7:99359709C>T	uc003urv.1	-	11	1312	c.1208G>A	c.(1207-1209)CGT>CAT	p.R403H	CYP3A4_uc003urw.1_Missense_Mutation_p.R402H|CYP3A4_uc011kiz.1_Missense_Mutation_p.R362H|CYP3A4_uc011kja.1_Missense_Mutation_p.R354H|CYP3A4_uc011kjb.1_Missense_Mutation_p.R253H	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	403					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	CTTTGGGTCACGGTGAAGAGC	0.507													T	99359709	T	T	99359709	3	4	103	1	0	0	0	0	1	0	0	0	4178	536	19	1	315	1	CYP3A4	7	99359709	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	1501341	99359709	59778954	39	7054											
ACHE	43	broad.mit.edu	37	chr7	100490909	100490909	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaggcagcacgtgccattcGtggttcaccaggacctgcgc	13	13	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr7:100490909G>A	uc003uxd.2	-	1	1101	c.945C>T	c.(943-945)CAC>CAT	p.H315H	ACHE_uc003uxe.2_Silent_p.H315H|ACHE_uc003uxf.2_Silent_p.H315H|ACHE_uc003uxg.2_Silent_p.H315H|ACHE_uc003uxh.2_Silent_p.H315H|ACHE_uc003uxi.2_Silent_p.H315H|ACHE_uc003uxj.1_Silent_p.H434H	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	315					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CGTGCCATTCGTGGTTCACCA	0.607													A	100490909	A	A	100490909	2	1	103	1	0	0	0	0	0	0	0	1	141	1136	40	1		1	ACHE	7	100490909	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	1131200	100490909	58647754	40	7055											
MUC17	140453	broad.mit.edu	37	chr7	100692247	100692247	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagttcaaacagacattcacGgaacaggtaagtctgggaga	12	7	3	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr7:100692247G>A	uc003uxp.1	+	5	12710	c.12657G>A	c.(12655-12657)ACG>ACA	p.T4219T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4219	Extracellular (Potential).|SEA.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGACATTCACGGAACAGGTAA	0.507													A	100692247	A	A	100692247	2	1	103	1	0	0	0	0	0	0	0	1	9974	1103	39	2		2	MUC17	7	100692247	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	201338	100692247	58446416	41	7056											
EPHB6	2051	broad.mit.edu	37	chr7	142561409	142561409	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtattgctggacaccaccGgagagacatctgagattggc	13	9	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr7:142561409G>A	uc011kst.1	+	6	908	c.121G>A	c.(121-123)GGA>AGA	p.G41R	EPHB6_uc011ksu.1_Missense_Mutation_p.G41R|EPHB6_uc003wbs.2_Intron|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Intron	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	41	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GGACACCACCGGAGAGACATC	0.597													A	142561409	A	A	142561409	3	1	103	1	0	0	0	0	1	0	0	0	5178	1117	39	2	127	2	EPHB6	7	142561409	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	41869162	142561409	16577254	42	7057											
OR2A12	346525	broad.mit.edu	37	chr7	143792982	143792982	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cattgtcatgtacatggcccCcaagtcaagccattctcaag	7	13	3	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr7:143792982C>A	uc011kty.1	+	1	782	c.782C>A	c.(781-783)CCC>CAC	p.P261H		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TACATGGCCCCCAAGTCAAGC	0.547													A	143792982	A	A	143792982	3	1	103	1	0	0	0	0	1	0	0	0	10975	623	22	5	784	5	OR2A12	7	143792982	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	1231573	143792982	15345681	43	7058											
DLC1	10395	broad.mit.edu	37	chr8	12952344	12952344	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agatctcgaaaatactgcttCagcatgtctgccacgtcata	7	11	4	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr8:12952344C>T	uc003wwm.2	-	12	3894	c.3450G>A	c.(3448-3450)CTG>CTA	p.L1150L	DLC1_uc003wwk.1_Silent_p.L713L|DLC1_uc003wwl.1_Silent_p.L747L|DLC1_uc011kxx.1_Silent_p.L639L	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1150	Rho-GAP.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						AATACTGCTTCAGCATGTCTG	0.468													T	12952344	T	T	12952344	2	4	103	1	0	0	0	0	0	0	0	1	4550	813	29	3		3	DLC1	8	12952344	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08		12952344	133411678	44	7059											
TUSC3	7991	broad.mit.edu	37	chr8	15531274	15531274	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtgtatagtctttgctatgActtctggccagatgtggaac	11	7	2	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr8:15531274A>G	uc003wwt.2	+	6	937	c.727A>G	c.(727-729)ACT>GCT	p.T243A	TUSC3_uc003wwr.2_Missense_Mutation_p.T243A|TUSC3_uc003wws.2_Missense_Mutation_p.T243A|TUSC3_uc003wwu.2_Missense_Mutation_p.T243A|TUSC3_uc003wwv.2_Missense_Mutation_p.T243A|TUSC3_uc003www.2_Missense_Mutation_p.T243A|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.T243A	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	243					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		CTTTGCTATGACTTCTGGCCA	0.383													G	15531274	G	G	15531274	3	3	103	1	0	0	0	0	1	0	0	0	16775	275	10	4	749	4	TUSC3	8	15531274	Missense_Mutation	SNP	A	TCGA-06-6694-01A-12D-1845-08	2578930	15531274	130832748	45	7060											
SFTPC	6440	broad.mit.edu	37	chr8	22020640	22020640	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagcccagcaacgcctggcCctgagtgagcacctggttac	12	14	0	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr8:22020640C>T	uc003xax.3	+	3	407	c.249C>T	c.(247-249)GCC>GCT	p.A83A	SFTPC_uc003xaw.3_Silent_p.A132A|SFTPC_uc011kza.1_Silent_p.A83A|SFTPC_uc003xaz.2_Silent_p.A83A|SFTPC_uc003xay.3_Silent_p.A83A|BMP1_uc011kzb.1_5'Flank|BMP1_uc003xba.2_5'Flank|BMP1_uc003xbb.2_5'Flank|BMP1_uc003xbe.2_5'Flank|BMP1_uc003xbc.2_5'Flank|BMP1_uc003xbd.2_5'Flank|BMP1_uc003xbf.2_5'Flank|BMP1_uc003xbg.2_5'Flank|BMP1_uc011kzc.1_5'Flank|BMP1_uc003xbh.2_5'Flank|BMP1_uc003xbi.2_5'Flank	NM_003018	NP_003009	P11686	PSPC_HUMAN	surfactant protein C precursor	83					respiratory gaseous exchange	extracellular space					0				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		AACGCCTGGCCCTGAGTGAGC	0.617													T	22020640	T	T	22020640	2	4	103	1	0	0	0	0	0	0	0	1	14192	610	22	3		3	SFTPC	8	22020640	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	6489366	22020640	124343382	46	7061											
ADAMDEC1	27299	broad.mit.edu	37	chr8	24256489	24256489	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcgcaagcaccacgtttgacAacttcctgagatggcacagt	10	12	0	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr8:24256489A>G	uc003xdz.2	+	9	1085	c.865A>G	c.(865-867)AAC>GAC	p.N289D	ADAMDEC1_uc010lub.2_Missense_Mutation_p.N210D|ADAMDEC1_uc011lab.1_Missense_Mutation_p.N210D	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	289	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CACGTTTGACAACTTCCTGAG	0.488													G	24256489	G	G	24256489	3	3	103	1	0	0	0	0	1	0	0	0	254	130	5	4	899	4	ADAMDEC1	8	24256489	Missense_Mutation	SNP	A	TCGA-06-6694-01A-12D-1845-08	2235849	24256489	122107533	47	7062											
JAK2	3717	broad.mit.edu	37	chr9	5080558	5080558	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acaattttatgaagataggcAtcagcttcctgcaccaaagt	7	9	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr9:5080558A>T	uc010mhm.2	+	17	2422	c.2309A>T	c.(2308-2310)CAT>CTT	p.H770L	JAK2_uc003ziw.2_Missense_Mutation_p.H770L	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	770	Protein kinase 1.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		GAAGATAGGCATCAGCTTCCT	0.358		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				T	5080558	T	T	5080558	3	4	103	1	0	0	0	0	1	0	0	0	7938	217	8	5	2371	5	JAK2	9	5080558	Missense_Mutation	SNP	A	TCGA-06-6694-01A-12D-1845-08		5080558	136132873	48	7063											
FAM120A	23196	broad.mit.edu	37	chr9	96289441	96289441	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcattttatgtttagccatAtcagcgggaacaagattggc	9	7	2	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr9:96289441A>C	uc004atw.2	+	8	1448	c.1423A>C	c.(1423-1425)ATC>CTC	p.I475L	FAM120A_uc004atv.2_Missense_Mutation_p.I475L|FAM120A_uc004atx.2_Missense_Mutation_p.I257L|FAM120A_uc004aty.2_Missense_Mutation_p.I256L|FAM120A_uc004atz.2_Missense_Mutation_p.I124L|FAM120A_uc010mrf.1_RNA	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	475						cytoplasm|plasma membrane	RNA binding				0						GTTTAGCCATATCAGCGGGAA	0.463													C	96289441	C	C	96289441	3	2	103	1	0	0	0	0	1	0	0	0	5415	449	16	5	1453	5	FAM120A	9	96289441	Missense_Mutation	SNP	A	TCGA-06-6694-01A-12D-1845-08	91208883	96289441	44923990	49	7064											
ZNF169	169841	broad.mit.edu	37	chr9	97063382	97063382	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactcagaggaggagctttaCgtagacagggtgtgtggaca	15	7	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr9:97063382C>T	uc004aum.1	+	5	1647	c.1542C>T	c.(1540-1542)TAC>TAT	p.Y514Y		NM_194320	NP_919301	Q14929	ZN169_HUMAN	zinc finger protein 169	514	C2H2-type 11; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				AGGAGCTTTACGTAGACAGGG	0.537													T	97063382	T	T	97063382	2	4	103	1	0	0	0	0	0	0	0	1	17739	547	19	1		1	ZNF169	9	97063382	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	773941	97063382	44150049	50	7065											
MYOF	26509	broad.mit.edu	37	chr10	95134679	95134679	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagtatcgagaactgtgacGttggcttttccttctgtgag	12	7	1	4			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr10:95134679G>A	uc001kin.2	-	23	2265	c.2142C>T	c.(2140-2142)AAC>AAT	p.N714N	MYOF_uc001kio.2_Silent_p.N701N|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	714	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GAACTGTGACGTTGGCTTTTC	0.448													A	95134679	A	A	95134679	2	1	103	1	0	0	0	0	0	0	0	1	10089	1136	40	1		1	MYOF	10	95134679	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08		95134679	40400068	51	7066											
LRRC27	80313	broad.mit.edu	37	chr10	134165159	134165159	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttacccgacctcttgtcaccGtaccaaatggcgatccgagc	8	15	2	0	rs147065829		TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr10:134165159G>A	uc010quw.1	+	7	1170	c.975G>A	c.(973-975)CCG>CCA	p.P325P	LRRC27_uc001llf.2_Missense_Mutation_p.R357H|LRRC27_uc010quv.1_Silent_p.P325P|LRRC27_uc001llg.2_RNA|LRRC27_uc001lli.2_Silent_p.P325P|LRRC27_uc001llj.2_Silent_p.P263P|LRRC27_uc001llk.3_Silent_p.P198P	NM_030626	NP_085129	Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27 isoform a	325										ovary(1)	1		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		TCTTGTCACCGTACCAAATGG	0.527													A	134165159	A	A	134165159	2	1	103	1	0	0	0	0	0	0	0	1	8981	1145	40	1		1	LRRC27	10	134165159	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	39030480	134165159	1369588	52	7067											
FAM160A2	84067	broad.mit.edu	37	chr11	6239211	6239211	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgcaggggtaggccgtcgGccagggctggaggcggggga	22	9	1	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr11:6239211G>A	uc001mcl.3	-	9	1964	c.1605C>T	c.(1603-1605)GGC>GGT	p.G535G	FAM160A2_uc001mck.3_Silent_p.G549G|FAM160A2_uc001mcm.2_Silent_p.G535G	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	535					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						TAGGCCGTCGGCCAGGGCTGG	0.652													A	6239211	A	A	6239211	2	1	103	1	0	0	0	0	0	0	0	1	5469	1190	42	3		3	FAM160A2	11	6239211	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08		6239211	128767305	53	7068											
SLC35C1	55343	broad.mit.edu	37	chr11	45827648	45827648	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctctggccgcctgctgccCtggtgccgtggacttcccca	12	18	1	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr11:45827648C>T	uc001nbp.2	+	1	1008	c.296C>T	c.(295-297)CCT>CTT	p.P99L	SLC35C1_uc001nbo.2_Missense_Mutation_p.P86L|SLC35C1_uc010rgm.1_Missense_Mutation_p.P86L	NM_018389	NP_060859	Q96A29	FUCT1_HUMAN	GDP-fucose transporter 1 isoform a	99						Golgi membrane|integral to membrane	GDP-fucose transmembrane transporter activity				0				GBM - Glioblastoma multiforme(35;0.227)		GCCTGCTGCCCTGGTGCCGTG	0.652													T	45827648	T	T	45827648	3	4	103	1	0	0	0	0	1	0	0	0	14579	681	24	3	298	3	SLC35C1	11	45827648	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	39588437	45827648	89178868	54	7069											
OR4C11	219429	broad.mit.edu	37	chr11	55371296	55371296	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgtaagtgtccatgcaggcaAgtttcaacaagggctgcaaa	11	8	1	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr11:55371296A>T	uc010rii.1	-	1	554	c.554T>A	c.(553-555)CTT>CAT	p.L185H		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CATGCAGGCAAGTTTCAACAA	0.398													T	55371296	T	T	55371296	3	4	103	1	0	0	0	0	1	0	0	0	11045	72	3	5	380	5	OR4C11	11	55371296	Missense_Mutation	SNP	A	TCGA-06-6694-01A-12D-1845-08	9543648	55371296	79635220	55	7070											
OR4P4	81300	broad.mit.edu	37	chr11	55405976	55405976	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcataatgatttctatcaCgtgcacccagctcattcacc	4	14	5	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr11:55405976C>T	uc010rij.1	+	1	143	c.143C>T	c.(142-144)ACG>ATG	p.T48M		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						ATTTCTATCACGTGCACCCAG	0.388													T	55405976	T	T	55405976	3	4	103	1	0	0	0	0	1	0	0	0	11080	536	19	1	145	1	OR4P4	11	55405976	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	34680	55405976	79600540	56	7071											
OR5M1	390168	broad.mit.edu	37	chr11	56380780	56380780	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atagcaaatgtctacaaaggAgaggtggccaaggaagaaat	12	5	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr11:56380780A>G	uc001nja.1	-	1	199	c.199T>C	c.(199-201)TCC>CCC	p.S67P		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TCTACAAAGGAGAGGTGGCCA	0.463													G	56380780	G	G	56380780	3	3	103	1	0	0	0	0	1	0	0	0	11172	304	11	4	752	4	OR5M1	11	56380780	Missense_Mutation	SNP	A	TCGA-06-6694-01A-12D-1845-08	974804	56380780	78625736	57	7072											
OR5AR1	219493	broad.mit.edu	37	chr11	56431356	56431356	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgtattttttcctctgcaaCctctcctttgttgacctggg	7	11	2	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr11:56431356C>A	uc010rjm.1	+	1	195	c.195C>A	c.(193-195)AAC>AAA	p.N65K		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCTCTGCAACCTCTCCTTTG	0.453													A	56431356	A	A	56431356	3	1	103	1	0	0	0	0	1	0	0	0	11145	506	18	5	197	5	OR5AR1	11	56431356	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	50576	56431356	78575160	58	7073											
LRP5	4041	broad.mit.edu	37	chr11	68191121	68191121	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgggggtggtgctgcgtggGgaccgcgacaagcccagggc	20	10	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr11:68191121G>A	uc001ont.2	+	14	3267	c.3192G>A	c.(3190-3192)GGG>GGA	p.G1064G	LRP5_uc009ysg.2_Silent_p.G474G	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1064	LDL-receptor class B 17.|Beta-propeller 4.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						TGCTGCGTGGGGACCGCGACA	0.677													A	68191121	A	A	68191121	2	1	103	1	0	0	0	0	0	0	0	1	8960	1219	43	3		3	LRP5	11	68191121	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	11759765	68191121	66815395	59	7074											
CLPB	81570	broad.mit.edu	37	chr11	72005108	72005108	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatagtgcacattgtagccGtcgaccagcacatctgccac	8	15	1	0	rs147296630		TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr11:72005108G>A	uc001osj.2	-	16	1883	c.1833C>T	c.(1831-1833)GAC>GAT	p.D611D	CLPB_uc010rqx.1_Silent_p.D566D|CLPB_uc010rqy.1_Silent_p.D552D|CLPB_uc001osk.2_Silent_p.D581D|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Silent_p.D410D|CLPB_uc001osi.2_Silent_p.D219D	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	611					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						CATTGTAGCCGTCGACCAGCA	0.612													A	72005108	A	A	72005108	2	1	103	1	0	0	0	0	0	0	0	1	3551	1136	40	1		1	CLPB	11	72005108	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	3813987	72005108	63001408	60	7075											
TMEM25	84866	broad.mit.edu	37	chr11	118403822	118403822	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaactacccctggctcacCaaccacacggtgcagctgca	8	17	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr11:118403822C>T	uc010rye.1	+	4	747	c.573C>T	c.(571-573)ACC>ACT	p.T191T	TMEM25_uc010ryd.1_Silent_p.T191T|TMEM25_uc001ptk.3_Silent_p.T191T|TMEM25_uc001pth.2_Silent_p.T191T|TMEM25_uc009zad.2_Silent_p.T191T|TMEM25_uc001pti.2_Silent_p.T87T|TMEM25_uc010ryf.1_Intron|TMEM25_uc001ptl.2_Silent_p.T191T|TMEM25_uc001ptm.2_Silent_p.T191T|TMEM25_uc001ptn.2_Silent_p.T191T	NM_032780	NP_116169	Q86YD3	TMM25_HUMAN	transmembrane protein 25 isoform 1	191	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		CCTGGCTCACCAACCACACGG	0.632													T	118403822	T	T	118403822	2	4	103	1	0	0	0	0	0	0	0	1	16147	581	21	3		3	TMEM25	11	118403822	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	46398714	118403822	16602694	61	7076											
MFSD5	84975	broad.mit.edu	37	chr12	53646716	53646716	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaccccctggaagggccTgcagcaatccctccttcctt	7	17	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr12:53646716T>A	uc001sci.1	+	2	288	c.97T>A	c.(97-99)TGC>AGC	p.C33S	MFSD5_uc001sch.1_Missense_Mutation_p.C140S	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	33					transport	integral to membrane				skin(2)|ovary(1)	3						TGGAAGGGCCTGCAGCAATCC	0.572													A	53646716	A	A	53646716	3	1	103	1	0	0	0	0	1	0	0	0	9534	1580	55	5	424	5	MFSD5	12	53646716	Missense_Mutation	SNP	T	TCGA-06-6694-01A-12D-1845-08		53646716	80205179	62	7077											
SPIC	121599	broad.mit.edu	37	chr12	101880531	101880531	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatgccaattaccatgagctAaatcaccatgattgctaaat	5	9	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr12:101880531A>G	uc001tid.2	+	6	888	c.729A>G	c.(727-729)CTA>CTG	p.L243L	SPIC_uc009zua.2_Silent_p.L118L|SPIC_uc010svp.1_Silent_p.L242L	NM_152323	NP_689536	Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	243						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						ACCATGAGCTAAATCACCATG	0.323													G	101880531	G	G	101880531	2	3	103	1	0	0	0	0	0	0	0	1	15050	349	13	4		4	SPIC	12	101880531	Silent	SNP	A	TCGA-06-6694-01A-12D-1845-08	48233815	101880531	31971364	63	7078											
CIT	11113	broad.mit.edu	37	chr12	120148180	120148180	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagagcccttcctcggtgccCaccaacaccacctgcaaggg	9	17	0	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr12:120148180C>T	uc001txi.1	-	38	4874	c.4821G>A	c.(4819-4821)GTG>GTA	p.V1607V	CIT_uc001txh.1_Silent_p.V1126V|CIT_uc001txj.1_Silent_p.V1649V	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1607	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CCTCGGTGCCCACCAACACCA	0.512													T	120148180	T	T	120148180	2	4	103	1	0	0	0	0	0	0	0	1	3438	581	21	3		3	CIT	12	120148180	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	18267649	120148180	13703715	64	7079											
OASL	8638	broad.mit.edu	37	chr12	121471350	121471350	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaagacgagagcatcggggActctctgctccatcctcagg	12	12	2	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr12:121471350A>G	uc001tzj.1	-	2	401	c.395T>C	c.(394-396)GTC>GCC	p.V132A	OASL_uc001tzk.1_Missense_Mutation_p.V132A	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	132					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGCATCGGGGACTCTCTGCTC	0.587													G	121471350	G	G	121471350	3	3	103	1	0	0	0	0	1	0	0	0	10802	275	10	4	1169	4	OASL	12	121471350	Missense_Mutation	SNP	A	TCGA-06-6694-01A-12D-1845-08	1323170	121471350	12380545	65	7080											
RIMBP2	23504	broad.mit.edu	37	chr12	130927081	130927081	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctccctccaggccgatgccGgaatggttgatgaagttctg	12	11	2	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr12:130927081G>A	uc001uil.2	-	8	929	c.765C>T	c.(763-765)TCC>TCT	p.S255S	RIMBP2_uc001uim.2_Silent_p.S163S|RIMBP2_uc001uin.1_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	255						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGCCGATGCCGGAATGGTTGA	0.597													A	130927081	A	A	130927081	2	1	103	1	0	0	0	0	0	0	0	1	13363	1103	39	2		2	RIMBP2	12	130927081	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	9455731	130927081	2924814	66	7081											
PABPC3	5042	broad.mit.edu	37	chr13	25671129	25671129	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaaaacaaatttacgttggtCgagctcagaaaaaagtggaa	10	5	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr13:25671129C>T	uc001upy.2	+	1	854	c.793C>T	c.(793-795)CGA>TGA	p.R265*		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	265	RRM 3.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TTACGTTGGTCGAGCTCAGAA	0.403													T	25671129	T	T	25671129	4	4	103	1	0	0	0	0	0	1	0	0	11365	876	31	2	795	2	PABPC3	13	25671129	Nonsense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08		25671129	89498749	67	7082											
OR4M1	441670	broad.mit.edu	37	chr14	20249075	20249075	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	accttcccagaggagttagtGatgatctgtagtagtggtct	12	7	2	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr14:20249075G>T	uc010tku.1	+	1	594	c.594G>T	c.(592-594)GTG>GTT	p.V198V		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGGAGTTAGTGATGATCTGTA	0.478													T	20249075	T	T	20249075	2	4	103	1	0	0	0	0	0	0	0	1	11075	1277	45	5		5	OR4M1	14	20249075	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08		20249075	87100465	68	7083											
JPH4	84502	broad.mit.edu	37	chr14	24040215	24040215	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcatcaggacccctcgaggaCgagcccctcaggaccagcat	11	16	2	0	rs144311601		TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr14:24040215C>T	uc001wkq.2	-	6	2643	c.1725G>A	c.(1723-1725)TCG>TCA	p.S575S	AP1G2_uc001wkl.2_5'Flank|AP1G2_uc001wkn.2_5'Flank|AP1G2_uc010tnp.1_5'Flank|AP1G2_uc010akt.2_5'Flank|JPH4_uc010tnr.1_Silent_p.S240S|JPH4_uc001wkr.2_Silent_p.S575S	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	575	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		CCCTCGAGGACGAGCCCCTCA	0.687													T	24040215	T	T	24040215	2	4	103	1	0	0	0	0	0	0	0	1	7963	523	19	1		1	JPH4	14	24040215	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	3791140	24040215	83309325	69	7084											
IRF9	10379	broad.mit.edu	37	chr14	24635334	24635334	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	catctcttccaatacagatgGagcaggcctttgcccgatac	8	13	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr14:24635334G>A	uc001wmq.2	+	9	1238	c.1111G>A	c.(1111-1113)GAG>AAG	p.E371K	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_Missense_Mutation_p.E155K	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	371					interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)		AATACAGATGGAGCAGGCCTT	0.597													A	24635334	A	A	24635334	3	1	103	1	0	0	0	0	1	0	0	0	7837	1175	41	3	1141	3	IRF9	14	24635334	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	595119	24635334	82714206	70	7085											
FNTB	2342	broad.mit.edu	37	chr14	65520032	65520032	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacatcctgatgtgctgccaGtgccctgcgggggggcttct	14	12	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr14:65520032G>A	uc001xia.2	+	10	1197	c.1032G>A	c.(1030-1032)CAG>CAA	p.Q344Q	FNTB_uc010tsl.1_Silent_p.Q378Q|FNTB_uc010tsm.1_Silent_p.Q298Q|MAX_uc001xic.1_Intron|FNTB_uc001xid.2_Silent_p.Q100Q|FNTB_uc010tso.1_Silent_p.Q259Q	NM_002028	NP_002019	P49356	FNTB_HUMAN	farnesyltransferase, CAAX box, beta	344	PFTB 5.				protein farnesylation	microtubule associated complex	protein binding|protein farnesyltransferase activity			ovary(1)	1				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		TGTGCTGCCAGTGCCCTGCGG	0.592													A	65520032	A	A	65520032	2	1	103	1	0	0	0	0	0	0	0	1	5978	1020	36	3		3	FNTB	14	65520032	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	40884698	65520032	41829508	71	7086											
MAP1A	4130	broad.mit.edu	37	chr15	43820051	43820051	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agaggcccaatccccaagtcCtcctcaccccattcctatgg	6	18	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr15:43820051C>G	uc001zrt.2	+	4	6847	c.6380C>G	c.(6379-6381)CCT>CGT	p.P2127R		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2127						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TCCCCAAGTCCTCCTCACCCC	0.582													G	43820051	G	G	43820051	3	3	103	1	0	0	0	0	1	0	0	0	9227	681	24	5	6382	5	MAP1A	15	43820051	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08		43820051	58711341	72	7087											
FGF7	2252	broad.mit.edu	37	chr15	49776594	49776594	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctaaatggacacacaacGgaggggaaatgtttgttgcc	12	8	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr15:49776594G>A	uc001zxn.2	+	4	1007	c.478G>A	c.(478-480)GGA>AGA	p.G160R	C15orf33_uc001zxl.2_Intron|C15orf33_uc001zxm.2_Intron	NM_002009	NP_002000	P21781	FGF7_HUMAN	fibroblast growth factor 7 precursor	160					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity				0		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	GACACACAACGGAGGGGAAAT	0.353													A	49776594	A	A	49776594	3	1	103	1	0	0	0	0	1	0	0	0	5857	1117	39	2	488	2	FGF7	15	49776594	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	5956543	49776594	52754798	73	7088											
BCL2L10	10017	broad.mit.edu	37	chr15	52404684	52404684	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gagagcacggaatccgccatCagcgccaccagctcgaagcg	12	15	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr15:52404684C>T	uc002abq.2	-	1	289	c.240G>A	c.(238-240)CTG>CTA	p.L80L		NM_020396	NP_065129	Q9HD36	B2L10_HUMAN	BCL2-like 10 (apoptosis facilitator)	70					activation of caspase activity|anti-apoptosis|female gamete generation|spermatogenesis	cytosol|integral to membrane|membrane fraction|mitochondrion|nuclear membrane	protein binding				0				all cancers(107;0.0148)		AATCCGCCATCAGCGCCACCA	0.692													T	52404684	T	T	52404684	2	4	103	1	0	0	0	0	0	0	0	1	1368	813	29	3		3	BCL2L10	15	52404684	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	2628090	52404684	50126708	74	7089											
RFX7	64864	broad.mit.edu	37	chr15	56387837	56387837	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccctgaatgtggaaccttttGgtccttcttaacactgcctt	7	12	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr15:56387837G>T	uc010bfn.2	-	9	2089	c.2089C>A	c.(2089-2091)CAA>AAA	p.Q697K	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Missense_Mutation_p.Q511K	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	600					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						GGAACCTTTTGGTCCTTCTTA	0.453													T	56387837	T	T	56387837	3	4	103	1	0	0	0	0	1	0	0	0	13268	1357	47	5	2297	5	RFX7	15	56387837	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	3983153	56387837	46143555	75	7090											
RPP25	54913	broad.mit.edu	37	chr15	75248658	75248658	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgcgtgacctggtgcaggccCgccaggcggcgcttgaggat	17	13	0	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr15:75248658C>A	uc002azj.1	-	1	1118	c.267G>T	c.(265-267)GCG>GCT	p.A89A		NM_017793	NP_060263	Q9BUL9	RPP25_HUMAN	ribonuclease P 25kDa subunit	89					tRNA processing	nucleus	protein binding|ribonuclease P activity|RNA binding				0						GGTGCAGGCCCGCCAGGCGGC	0.736													A	75248658	A	A	75248658	2	1	103	1	0	0	0	0	0	0	0	1	13611	639	23	5		5	RPP25	15	75248658	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	18860821	75248658	27282734	76	7091											
IGF1R	3480	broad.mit.edu	37	chr15	99251218	99251218	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacattgtggggaataagccCccaaaggaatgtggggacct	13	8	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr15:99251218C>T	uc002bul.2	+	2	572	c.522C>T	c.(520-522)CCC>CCT	p.P174P	IGF1R_uc010urq.1_Silent_p.P174P|IGF1R_uc010bon.2_Silent_p.P174P	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	174					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GGAATAAGCCCCCAAAGGAAT	0.517													T	99251218	T	T	99251218	2	4	103	1	0	0	0	0	0	0	0	1	7571	610	22	3		3	IGF1R	15	99251218	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	24002560	99251218	3280174	77	7092											
TEKT5	146279	broad.mit.edu	37	chr16	10788195	10788195	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcagttcacctcattggccGcgcactccagccgcctcttg	10	17	3	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr16:10788195G>A	uc002czz.1	-	1	608	c.536C>T	c.(535-537)GCG>GTG	p.A179V		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	179	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						CTCATTGGCCGCGCACTCCAG	0.577													A	10788195	A	A	10788195	3	1	103	1	0	0	0	0	1	0	0	0	15753	1087	38	1	949	1	TEKT5	16	10788195	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08		10788195	79566558	78	7093											
ITGAM	3684	broad.mit.edu	37	chr16	31286944	31286944	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccaagccgcctcgtgatcaCgtgttccaggtgaataactt	9	12	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr16:31286944C>T	uc002ebq.2	+	9	1031	c.933C>T	c.(931-933)CAC>CAT	p.H311H	ITGAM_uc002ebr.2_Silent_p.H311H|ITGAM_uc010cam.1_Translation_Start_Site	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	311	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CTCGTGATCACGTGTTCCAGG	0.512													T	31286944	T	T	31286944	2	4	103	1	0	0	0	0	0	0	0	1	7887	535	19	1		1	ITGAM	16	31286944	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	20498749	31286944	59067809	79	7094											
DULLARD	23399	broad.mit.edu	37	chr17	7154554	7154554	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaggtaaatgaagaagctcCagagcttggcggcgaaggcc	15	8	0	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr17:7154554C>T	uc002gfd.2	-	1	442	c.62G>A	c.(61-63)TGG>TAG	p.W21*	DULLARD_uc002gfe.2_Nonsense_Mutation_p.W21*|DULLARD_uc002gff.2_Nonsense_Mutation_p.W21*|DULLARD_uc002gfc.2_RNA|C17orf81_uc002gfg.1_5'Flank|C17orf81_uc002gfj.2_5'Flank|C17orf81_uc010cmb.2_5'Flank|C17orf81_uc002gfh.1_5'Flank|C17orf81_uc002gfi.1_5'Flank|C17orf81_uc002gfk.1_5'Flank|C17orf81_uc002gfl.1_5'Flank	NM_001143775	NP_001137247	O95476	CNEP1_HUMAN	dullard homolog	21	Helical; (Potential).				nuclear envelope organization|protein dephosphorylation	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein serine/threonine phosphatase activity				0						GAAGAAGCTCCAGAGCTTGGC	0.542													T	7154554	T	T	7154554	4	4	103	1	0	0	0	0	0	1	0	0	4799	595	21	3	704	3	DULLARD	17	7154554	Nonsense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08		7154554	74040656	80	7095											
TP53	7157	broad.mit.edu	37	chr17	7577568	7577568	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgcccatgcaggaactgttaCacatgtagttgtagtggatg	12	8	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr17:7577568C>A	uc002gim.2	-	7	907	c.713G>T	c.(712-714)TGT>TTT	p.C238F	TP53_uc002gig.1_Missense_Mutation_p.C238F|TP53_uc002gih.2_Missense_Mutation_p.C238F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106F|TP53_uc010cng.1_Missense_Mutation_p.C106F|TP53_uc002gii.1_Missense_Mutation_p.C106F|TP53_uc010cnh.1_Missense_Mutation_p.C238F|TP53_uc010cni.1_Missense_Mutation_p.C238F|TP53_uc002gij.2_Missense_Mutation_p.C238F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145F|TP53_uc002gio.2_Missense_Mutation_p.C106F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577568	A	A	7577568	3	1	103	1	0	0	0	0	1	0	0	0	16378	478	17	5	577	5	TP53	17	7577568	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	423014	7577568	73617642	81	7096											
LSMD1	84316	broad.mit.edu	37	chr17	7760481	7760503	+	Frame_Shift_Del	DEL	CTCAGCCGCCGAGTCCTCGCGCT	-	-													tctagctgctgtcgggcgcgCtcagccgccgagtcctcgcg							TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr17:7760481_7760503delCTCAGCCGCCGAGTCCTCGCGCT	uc002giz.2	-	2	194_216	c.95_117delAGCGCGAGGACTCGGCGGCTGAG	c.(94-117)GAGCGCGAGGACTCGGCGGCTGAGfs	p.E32fs	LSMD1_uc002gja.2_Frame_Shift_Del_p.E80fs|CYB5D1_uc010cnn.1_5'Flank|CYB5D1_uc002gjb.3_5'Flank			Q9BRA0	LSMD1_HUMAN	RecName: Full=LSM domain-containing protein 1; AltName: Full=Phosphonoformate immuno-associated protein 2;	32_39	Potential.					cytoplasm|nucleus				ovary(1)	1		all_cancers(10;0.11)|Prostate(122;0.219)				GTCGGGCGCGCTCAGCCGCCGAGTCCTCGCGCTCTCCGTCCGA	0.682											OREG0024146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	7760503	-	-	7760481	7	5	103	1	0	1	0	1	0	0	0	0	9062	796	28	0	268	0	LSMD1	17	7760481	Frame_Shift_Del	DEL	CTCAGCCGCCGAGTCCTCGCGCT	TCGA-06-6694-01A-12D-1845-08	182913	7760481	73434729	82	7097											
PER1	5187	broad.mit.edu	37	chr17	8048179	8048179	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttccttctgtgtgtgcaggGacagcacggccttggtcagc	13	12	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr17:8048179G>A	uc002gkd.2	-	18	2589	c.2351C>T	c.(2350-2352)TCC>TTC	p.S784F	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Missense_Mutation_p.S768F	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	784	CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						TGTGTGCAGGGACAGCACGGC	0.443			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					A	8048179	A	A	8048179	3	1	103	1	0	0	0	0	1	0	0	0	11729	1174	41	3	1545	3	PER1	17	8048179	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	287698	8048179	73147031	83	7098											
LLGL1	3996	broad.mit.edu	37	chr17	18135847	18135847	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagttcacaggcctgcaccGggatgcagccactgtcacac	12	14	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr17:18135847G>A	uc002gsp.2	+	3	279	c.218G>A	c.(217-219)CGG>CAG	p.R73Q		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	73					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					GGCCTGCACCGGGATGCAGCC	0.587													A	18135847	A	A	18135847	3	1	103	1	0	0	0	0	1	0	0	0	8833	1116	39	2	228	2	LLGL1	17	18135847	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	10087668	18135847	63059363	84	7099											
MBTD1	54799	broad.mit.edu	37	chr17	49270165	49270165	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtgatgctggaggctgtagTtgatatccagttaactgaca	12	6	0	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr17:49270165T>C	uc002itr.3	-	15	2012	c.1668A>G	c.(1666-1668)CAA>CAG	p.Q556Q	MBTD1_uc002itp.3_Silent_p.Q392Q|MBTD1_uc002itq.3_3'UTR	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	556	MBT 4.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.Q392Q(1)		ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			GAGGCTGTAGTTGATATCCAG	0.423													C	49270165	C	C	49270165	2	2	103	1	0	0	0	0	0	0	0	1	9360	1722	60	4		4	MBTD1	17	49270165	Silent	SNP	T	TCGA-06-6694-01A-12D-1845-08	31134318	49270165	31925045	85	7100											
BRIP1	83990	broad.mit.edu	37	chr17	59761146	59761147	+	Frame_Shift_Ins	INS	-	T	T													agagcggatgttcagaatgaINSttttttctagtaagggtggc							TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr17:59761146_59761147insT	uc002izk.1	-	20	3401_3402	c.3260_3261insA	c.(3259-3261)AATfs	p.N1087fs		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	1087					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						GTTCAGAATGATTTTTTCTAGT	0.376			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				T	59761147	T	T	59761146	7	5	103	1	0	1	1	0	0	0	0	0	1514	330	12	0	492	0	BRIP1	17	59761146	Frame_Shift_Ins	INS	-	TCGA-06-6694-01A-12D-1845-08	10490981	59761146	21434064	86	7101											
ZBTB7C	201501	broad.mit.edu	37	chr18	45566526	45566526	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggtcccagaggcccccccGgcaggtcagggaacatgtcc	14	15	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr18:45566526G>A	uc002lda.2	-	1	969	c.953C>T	c.(952-954)CCG>CTG	p.P318L	ZBTB7C_uc002ldb.2_Missense_Mutation_p.P318L|ZBTB7C_uc010dnu.2_Missense_Mutation_p.P327L|ZBTB7C_uc010dnv.2_Missense_Mutation_p.P340L|ZBTB7C_uc010dnw.2_Missense_Mutation_p.P318L|ZBTB7C_uc010dnx.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dny.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dnz.1_Missense_Mutation_p.P340L|ZBTB7C_uc010dob.1_Missense_Mutation_p.P318L|ZBTB7C_uc010doc.1_Missense_Mutation_p.P327L|ZBTB7C_uc010dod.1_Missense_Mutation_p.P340L|ZBTB7C_uc010doe.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dof.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dog.1_Missense_Mutation_p.P318L|ZBTB7C_uc010doh.1_Missense_Mutation_p.P327L|ZBTB7C_uc010doi.1_Missense_Mutation_p.P318L|ZBTB7C_uc010doj.1_Missense_Mutation_p.P327L|ZBTB7C_uc010dok.1_Missense_Mutation_p.P367L|ZBTB7C_uc010dol.1_Missense_Mutation_p.P327L|ZBTB7C_uc010doa.1_Missense_Mutation_p.P340L|ZBTB7C_uc010don.1_Missense_Mutation_p.P326L|ZBTB7C_uc010doo.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dop.1_Missense_Mutation_p.P318L|ZBTB7C_uc010doq.1_Missense_Mutation_p.P327L|ZBTB7C_uc010dor.1_Missense_Mutation_p.P340L|ZBTB7C_uc010dos.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dot.1_Missense_Mutation_p.P318L|ZBTB7C_uc010dou.1_Missense_Mutation_p.P327L|ZBTB7C_uc010dom.1_Missense_Mutation_p.P327L	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	318	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AGGCCCCCCCGGCAGGTCAGG	0.617													A	45566526	A	A	45566526	3	1	103	1	0	0	0	0	1	0	0	0	17552	1116	39	2	914	2	ZBTB7C	18	45566526	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08		45566526	32510722	87	7102											
C3	718	broad.mit.edu	37	chr19	6680198	6680198	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aataggcgtagaccttgactGctccaggctggataagctct	11	10	1	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr19:6680198G>T	uc002mfm.2	-	36	4489	c.4427C>A	c.(4426-4428)GCA>GAA	p.A1476E	C3_uc002mfl.2_Missense_Mutation_p.A212E	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1476					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GACCTTGACTGCTCCAGGCTG	0.512													T	6680198	T	T	6680198	3	4	103	1	0	0	0	0	1	0	0	0	2204	1319	46	5	588	5	C3	19	6680198	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08		6680198	52448785	88	7103											
KANK3	256949	broad.mit.edu	37	chr19	8389585	8389585	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtgtccaggcgcccatactCactggcacacatcagcgctg	11	15	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr19:8389585C>T	uc010dwa.2	-	9	2278	c.2212G>A	c.(2212-2214)GAG>AAG	p.E738K		NM_198471	NP_940873	Q6NY19	KANK3_HUMAN	ankyrin repeat domain 47	738	ANK 4.										0						CGCCCATACTCACTGGCACAC	0.627													T	8389585	T	T	8389585	3	4	103	1	0	0	0	0	1	0	0	0	7978	835	29	3	265	3	KANK3	19	8389585	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	1709387	8389585	50739398	89	7104											
ZNF626	199777	broad.mit.edu	37	chr19	20807460	20807460	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgtagtaaggttagaggagTacttaaaagctttgccacat	11	5	0	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr19:20807460T>C	uc002npb.1	-	4	1373	c.1223A>G	c.(1222-1224)TAC>TGC	p.Y408C	ZNF626_uc002npc.1_Missense_Mutation_p.Y332C	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	408	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						GTTAGAGGAGTACTTAAAAGC	0.408													C	20807460	C	C	20807460	3	2	103	1	0	0	0	0	1	0	0	0	18047	1638	57	4	367	4	ZNF626	19	20807460	Missense_Mutation	SNP	T	TCGA-06-6694-01A-12D-1845-08	12417875	20807460	38321523	90	7105											
ZNF257	113835	broad.mit.edu	37	chr19	22270778	22270778	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttgtttttatttcttttaGttatgtgttctcatattgct	6	4	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr19:22270778G>A	uc010ecx.2	+	4	396	c.227_splice	c.e4-1	p.V76_splice	ZNF257_uc010ecy.2_Splice_Site_p.V44_splice	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTTCTTTTAGTTATGTGTTC	0.294													A	22270778	A	A	22270778	5	1	103	1	0	0	0	0	0	0	1	0	17797	1043	36	3	240	3	ZNF257	19	22270778	Splice_Site	SNP	G	TCGA-06-6694-01A-12D-1845-08	1463318	22270778	36858205	91	7106											
ZNF302	55900	broad.mit.edu	37	chr19	35175737	35175737	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgcattgaatgtgggaaggcCtttagccatggctcatcact	11	9	2	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr19:35175737C>G	uc002nvr.1	+	6	1190	c.927C>G	c.(925-927)GCC>GCG	p.A309A	ZNF302_uc002nvp.1_Silent_p.A265A|ZNF302_uc002nvq.1_Silent_p.A265A|ZNF302_uc002nvs.1_Silent_p.A265A	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	344	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GTGGGAAGGCCTTTAGCCATG	0.448													G	35175737	G	G	35175737	2	3	103	1	0	0	0	0	0	0	0	1	17829	668	24	5		5	ZNF302	19	35175737	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	12904959	35175737	23953246	92	7107											
CGB8	94115	broad.mit.edu	37	chr19	49551985	49551985	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggccctgcagtcttacctgGaacatctccatccttggtgt	10	13	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr19:49551985G>A	uc002pmb.3	-	1	384	c.12C>T	c.(10-12)TTC>TTT	p.F4F	CGB_uc010yad.1_Intron|CGB8_uc002pma.2_5'Flank|CGB8_uc002pmc.2_Intron	NM_033183	NP_149439	P01233	CGHB_HUMAN	chorionic gonadotropin, beta polypeptide 8	4					apoptosis|cell-cell signaling|cellular nitrogen compound metabolic process|female gamete generation|hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Choriogonadotropin alfa(DB00097)	GTCTTACCTGGAACATCTCCA	0.602													A	49551985	A	A	49551985	2	1	103	1	0	0	0	0	0	0	0	1	3301	1165	41	3		3	CGB8	19	49551985	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	14376248	49551985	9576998	93	7108											
C19orf18	147685	broad.mit.edu	37	chr19	58485726	58485726	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatggagtccatctgcataCggcaagcataaatgaagttg	12	7	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr19:58485726C>T	uc002qqv.2	-	1	179	c.75G>A	c.(73-75)CCG>CCA	p.P25P		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	25						integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		CATCTGCATACGGCAAGCATA	0.393													T	58485726	T	T	58485726	2	4	103	1	0	0	0	0	0	0	0	1	1910	523	19	1		1	C19orf18	19	58485726	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	8933741	58485726	643257	94	7109											
RALGAPA2	57186	broad.mit.edu	37	chr20	20571899	20571899	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacctgctgctgctgtcccaCtgtgagatggccagatccgg	13	13	0	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr20:20571899C>T	uc002wrz.2	-	17	2406	c.2263G>A	c.(2263-2265)GTG>ATG	p.V755M	RALGAPA2_uc010gcx.2_Missense_Mutation_p.V459M|RALGAPA2_uc010zsg.1_Missense_Mutation_p.V203M	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	755					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TGCTGTCCCACTGTGAGATGG	0.512													T	20571899	T	T	20571899	3	4	103	1	0	0	0	0	1	0	0	0	13014	565	20	3	3450	3	RALGAPA2	20	20571899	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08		20571899	42453621	95	7110											
MYLK2	85366	broad.mit.edu	37	chr20	30409482	30409482	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgttccctcagagaaatcCgaggtggggcaggccctctg	14	12	2	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr20:30409482C>T	uc002wwq.2	+	4	816	c.714C>T	c.(712-714)TCC>TCT	p.S238S		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	238					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CAGAGAAATCCGAGGTGGGGC	0.637													T	30409482	T	T	30409482	2	4	103	1	0	0	0	0	0	0	0	1	10057	639	23	2		2	MYLK2	20	30409482	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	9837583	30409482	32616038	96	7111											
TTPAL	79183	broad.mit.edu	37	chr20	43115268	43115268	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attcggataaaagcagtccaTgtggtgaatgaacctcgaat	10	7	0	2			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr20:43115268T>C	uc002xmc.1	+	5	796	c.672T>C	c.(670-672)CAT>CAC	p.H224H	TTPAL_uc002xmd.1_Silent_p.H224H|TTPAL_uc010ggr.1_Silent_p.H37H	NM_024331	NP_077307	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	224	CRAL-TRIO.					intracellular	transporter activity			breast(1)	1						AAGCAGTCCATGTGGTGAATG	0.408													C	43115268	C	C	43115268	2	2	103	1	0	0	0	0	0	0	0	1	16734	1461	51	4		4	TTPAL	20	43115268	Silent	SNP	T	TCGA-06-6694-01A-12D-1845-08	12705786	43115268	19910252	97	7112											
TRAPPC10	7109	broad.mit.edu	37	chr21	45513965	45513965	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatctacagcaagcagtcgGtgttcttcgtctgggaactc	10	12	3	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr21:45513965G>A	uc002zea.2	+	20	3188	c.3019G>A	c.(3019-3021)GTG>ATG	p.V1007M	TRAPPC10_uc010gpo.2_Missense_Mutation_p.V718M|TRAPPC10_uc011afa.1_Missense_Mutation_p.V385M|TRAPPC10_uc011afb.1_Missense_Mutation_p.V112M	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1007					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CAAGCAGTCGGTGTTCTTCGT	0.542													A	45513965	A	A	45513965	3	1	103	1	0	0	0	0	1	0	0	0	16454	1261	44	3	3097	3	TRAPPC10	21	45513965	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08		45513965	2615930	98	7113											
COL6A1	1291	broad.mit.edu	37	chr21	47421892	47421892	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagttcgagccagggcagtcGtacgcgggtgtggtgcagta	17	9	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr21:47421892G>A	uc002zhu.1	+	31	2076	c.1974G>A	c.(1972-1974)TCG>TCA	p.S658S	COL6A1_uc010gqd.1_5'UTR|COL6A1_uc002zhv.1_5'UTR|COL6A1_uc002zhw.1_5'Flank	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	658	VWFA 2.|C-terminal globular domain.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CAGGGCAGTCGTACGCGGGTG	0.652													A	47421892	A	A	47421892	2	1	103	1	0	0	0	0	0	0	0	1	3699	1132	40	1		1	COL6A1	21	47421892	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	1907927	47421892	708003	99	7114											
CCT8L2	150160	broad.mit.edu	37	chr22	17072055	17072055	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccactcatttctgccatcacGtctgagacagctaagcctgc	7	15	4	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chr22:17072055G>A	uc002zlp.1	-	1	1646	c.1386C>T	c.(1384-1386)GAC>GAT	p.D462D		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	462					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTGCCATCACGTCTGAGACAG	0.527													A	17072055	A	A	17072055	2	1	103	1	0	0	0	0	0	0	0	1	2961	1136	40	1		1	CCT8L2	22	17072055	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08		17072055	34232511	100	7115											
RAI2	10742	broad.mit.edu	37	chrX	17819726	17819726	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcggcaggaccagaggggaGttgaggtgctgaaagacgtg	19	6	0	4			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:17819726G>A	uc004cyf.2	-	3	975	c.405C>T	c.(403-405)AAC>AAT	p.N135N	RAI2_uc004cyg.2_Silent_p.N135N|RAI2_uc010nfa.2_Silent_p.N135N|RAI2_uc004cyh.3_Silent_p.N135N|RAI2_uc011miy.1_Silent_p.N85N	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	135					embryo development			p.N135D(1)		ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					CCAGAGGGGAGTTGAGGTGCT	0.642													A	17819726	A	A	17819726	2	1	103	1	0	0	0	0	0	0	0	1	13009	1020	36	3		3	RAI2	23	17819726	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08		17819726	137450834	101	7116											
ACOT9	23597	broad.mit.edu	37	chrX	23731303	23731303	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caaatgttgcatccaaaacaGgacaaaattcatcaccatgt	5	10	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:23731303G>T	uc004dap.2	-	8	730	c.584C>A	c.(583-585)CCT>CAT	p.P195H	ACOT9_uc004dao.2_Missense_Mutation_p.P204H|ACOT9_uc004daq.2_Missense_Mutation_p.P153H|ACOT9_uc004dar.2_Missense_Mutation_p.P135H|ACOT9_uc011mjt.1_Intron|ACOT9_uc004das.2_Missense_Mutation_p.P135H|ACOT9_uc004dat.1_Missense_Mutation_p.P195H	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	195					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						ATCCAAAACAGGACAAAATTC	0.299													T	23731303	T	T	23731303	3	4	103	1	0	0	0	0	1	0	0	0	157	1000	35	5	767	5	ACOT9	23	23731303	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	5911577	23731303	131539257	102	7117											
FAM47C	442444	broad.mit.edu	37	chrX	37027694	37027694	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggagtgtctcctctcttccCggagcctcccaagactcgca	9	16	2	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:37027694C>T	uc004ddl.1	+	1	1225	c.1211C>T	c.(1210-1212)CCG>CTG	p.P404L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	404										ovary(3)	3						CCTCTCTTCCCGGAGCCTCCC	0.607													T	37027694	T	T	37027694	3	4	103	1	0	0	0	0	1	0	0	0	5571	652	23	2	1213	2	FAM47C	23	37027694	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	13296391	37027694	118242866	103	7118											
SYN1	6853	broad.mit.edu	37	chrX	47478794	47478794	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaccagcagcaccctggaggCggctcccccgcggcctgcgc	14	19	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:47478794C>G	uc004die.2	-	1	463	c.334G>C	c.(334-336)GCC>CCC	p.A112P	SYN1_uc004did.2_Missense_Mutation_p.A112P	NM_006950	NP_008881	P17600	SYN1_HUMAN	synapsin I isoform Ia	112	B; linker.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			ovary(1)	1						ACCCTGGAGGCGGCTCCCCCG	0.716													G	47478794	G	G	47478794	3	3	103	1	0	0	0	0	1	0	0	0	15437	768	27	5	1835	5	SYN1	23	47478794	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	10451100	47478794	107791766	104	7119											
ZNF182	7569	broad.mit.edu	37	chrX	47836621	47836621	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acattcaggacactcaaaggGtctctctcctgtatgagttc	8	11	4	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:47836621G>A	uc004dir.2	-	7	1211	c.865C>T	c.(865-867)CCC>TCC	p.P289S	ZNF182_uc004dis.2_Missense_Mutation_p.P270S|ZNF182_uc004dit.2_Missense_Mutation_p.P289S|ZNF182_uc011mlu.1_Missense_Mutation_p.P269S	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CACTCAAAGGGTCTCTCTCCT	0.403													A	47836621	A	A	47836621	3	1	103	1	0	0	0	0	1	0	0	0	17747	1261	44	3	1058	3	ZNF182	23	47836621	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	357827	47836621	107433939	105	7120											
SMC1A	8243	broad.mit.edu	37	chrX	53439849	53439849	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcccaggtctgcctcttaCttgatctccttctcaatctg	7	14	5	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:53439849C>T	uc004dsg.2	-	5	923	c.854_splice	c.e5+1	p.K285_splice	SMC1A_uc011moe.1_Splice_Site_p.K263_splice|SMC1A_uc011mof.1_Intron	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A						cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CTGCCTCTTACTTGAtctcct	0.264													T	53439849	T	T	53439849	5	4	103	1	0	0	0	0	0	0	1	0	14781	579	20	3	2930	3	SMC1A	23	53439849	Splice_Site	SNP	C	TCGA-06-6694-01A-12D-1845-08	5603228	53439849	101830711	106	7121											
P2RY10	27334	broad.mit.edu	37	chrX	78216911	78216911	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccttgcaagtctctgctgCcttttggatccaattcttta	7	11	2	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:78216911C>T	uc004ede.2	+	4	1263	c.894C>T	c.(892-894)TGC>TGT	p.C298C	P2RY10_uc004edf.2_Silent_p.C298C	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	298	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						GTCTCTGCTGCCTTTTGGATC	0.483													T	78216911	T	T	78216911	2	4	103	1	0	0	0	0	0	0	0	1	11347	747	26	3		3	P2RY10	23	78216911	Silent	SNP	C	TCGA-06-6694-01A-12D-1845-08	24777062	78216911	77053649	107	7122											
PABPC5	140886	broad.mit.edu	37	chrX	90690820	90690820	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ccttgaacaccatgaattttGatttgattaatggaaaacca	6	7	0	4			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:90690820G>T	uc004efg.2	+	2	684	c.244G>T	c.(244-246)GAT>TAT	p.D82Y	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	82	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CATGAATTTTGATTTGATTAA	0.483													T	90690820	T	T	90690820	3	4	103	1	0	0	0	0	1	0	0	0	11367	1290	45	5	246	5	PABPC5	23	90690820	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	12473909	90690820	64579740	108	7123											
PABPC5	140886	broad.mit.edu	37	chrX	90690988	90690988	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acattctgtcctgcaaagtcGtatgcgatgacaacggctct	9	11	2	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:90690988G>A	uc004efg.2	+	2	852	c.412G>A	c.(412-414)GTA>ATA	p.V138I	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	138	RRM 2.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CTGCAAAGTCGTATGCGATGA	0.453													A	90690988	A	A	90690988	3	1	103	1	0	0	0	0	1	0	0	0	11367	1145	40	1	414	1	PABPC5	23	90690988	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	168	90690988	64579572	109	7124											
BHLHB9	80823	broad.mit.edu	37	chrX	102005060	102005060	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttgctcagttttccttccccTgaaatgagaaaaaagactgt	7	9	1	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:102005060T>A	uc010nog.2	+	4	1708	c.1137T>A	c.(1135-1137)CCT>CCA	p.P379P	BHLHB9_uc011mrq.1_Silent_p.P379P|BHLHB9_uc011mrr.1_Silent_p.P379P|BHLHB9_uc011mrs.1_Silent_p.P379P|BHLHB9_uc011mrt.1_Silent_p.P379P|BHLHB9_uc004ejo.2_Silent_p.P379P|BHLHB9_uc011mru.1_Silent_p.P379P|BHLHB9_uc011mrv.1_Silent_p.P379P	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	379						cytoplasm|nucleus	binding			ovary(2)	2						TTCCTTCCCCTGAAATGAGAA	0.378													A	102005060	A	A	102005060	2	1	103	1	0	0	0	0	0	0	0	1	1420	1567	55	5		5	BHLHB9	23	102005060	Silent	SNP	T	TCGA-06-6694-01A-12D-1845-08	11314072	102005060	53265500	110	7125											
AKAP14	158798	broad.mit.edu	37	chrX	119048716	119048716	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tagagtttgtagagaggaaaGacttaattcacagcttcctc	9	7	1	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:119048716G>C	uc004ese.2	+	5	454	c.316G>C	c.(316-318)GAC>CAC	p.D106H	AKAP14_uc004esf.2_Intron	NM_178813	NP_848928	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14 isoform a	106						cytoplasm					0						AGAGAGGAAAGACTTAATTCA	0.408													C	119048716	C	C	119048716	3	2	103	1	0	0	0	0	1	0	0	0	450	942	33	5	335	5	AKAP14	23	119048716	Missense_Mutation	SNP	G	TCGA-06-6694-01A-12D-1845-08	17043656	119048716	36221844	111	7126											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299171	125299171	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcctccacatccctcggaCggatgtgggcatatactggg	13	12	0	0			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:125299171C>T	uc004euk.1	-	1	764	c.737G>A	c.(736-738)CGT>CAT	p.R246H		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	246										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						ATCCCTCGGACGGATGTGGGC	0.647													T	125299171	T	T	125299171	3	4	103	1	0	0	0	0	1	0	0	0	4265	536	19	1	658	1	DCAF12L2	23	125299171	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	6250455	125299171	29971389	112	7127											
ZNF449	203523	broad.mit.edu	37	chrX	134494349	134494349	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gggagagacacctgagaactCcaacttggaagaacctctca	10	11	1	3			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:134494349C>G	uc004eys.2	+	5	1070	c.905C>G	c.(904-906)TCC>TGC	p.S302C	ZNF449_uc004eyt.2_Missense_Mutation_p.S182C|ZNF449_uc004eyu.2_Missense_Mutation_p.S108C	NM_152695	NP_689908	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	302					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGAGAACTCCAACTTGGAA	0.468													G	134494349	G	G	134494349	3	3	103	1	0	0	0	0	1	0	0	0	17917	855	30	5	919	5	ZNF449	23	134494349	Missense_Mutation	SNP	C	TCGA-06-6694-01A-12D-1845-08	9195178	134494349	20776211	113	7128											
FLNA	2316	broad.mit.edu	37	chrX	153581222	153581222	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taggtgaccctgcacgtcccGtcctccaggtcctctgtgtt	10	15	1	1			TCGA-06-6694-01A-12D-1845-08	TCGA-06-6694-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	b5a5717d-0e3d-4b44-82f3-5b68187beb52	76e56e2a-adf5-4aab-98e8-9c77fa53c024	g.chrX:153581222G>A	uc004fkk.2	-	39	6546	c.6297C>T	c.(6295-6297)GAC>GAT	p.D2099D	FLNA_uc004fki.2_Silent_p.D142D|FLNA_uc011mzn.1_Silent_p.D232D|FLNA_uc010nuu.1_Silent_p.D2091D	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2099	Filamin 19.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGCACGTCCCGTCCTCCAGGT	0.602													A	153581222	A	A	153581222	2	1	103	1	0	0	0	0	0	0	0	1	5933	1136	40	1		1	FLNA	23	153581222	Silent	SNP	G	TCGA-06-6694-01A-12D-1845-08	19086873	153581222	1689338	114	7129											
NBPF1	55672	broad.mit.edu	37	chr1	16892156	16892156	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaagagaaaagccaacatgTttttcctccaatgcataaaa	5	9	1	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr1:16892156T>C	uc009vos.1	-	28	4149	c.3261A>G	c.(3259-3261)AAA>AAG	p.K1087K	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1087	NBPF 7.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AGCCAACATGTTTTTCCTCCA	0.438													C	16892156	C	C	16892156	2	2	104	1	0	0	0	0	0	0	0	1	10192	1722	60	4		4	NBPF1	1	16892156	Silent	SNP	T	TCGA-06-6695-01A-11D-1845-08		16892156	232358465	1	7130											
EPHA8	2046	broad.mit.edu	37	chr1	22924331	22924331	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaccatcccaacatcatccGcctcgagggtgtcgtcaccc	8	18	2	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr1:22924331G>A	uc001bfx.1	+	11	2218	c.2093G>A	c.(2092-2094)CGC>CAC	p.R698H		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	698	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AACATCATCCGCCTCGAGGGT	0.642													A	22924331	A	A	22924331	3	1	104	1	0	0	0	0	1	0	0	0	5173	1087	38	1	2308	1	EPHA8	1	22924331	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	6032175	22924331	226326290	2	7131											
ATP1A2	477	broad.mit.edu	37	chr1	160106465	160106465	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcctcgactgggatgaccGgaccatgaatgatctggagg	14	11	1	3			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr1:160106465G>A	uc001fvc.2	+	19	2801	c.2669G>A	c.(2668-2670)CGG>CAG	p.R890Q	ATP1A2_uc001fvb.2_Missense_Mutation_p.R890Q|ATP1A2_uc001fvd.2_Missense_Mutation_p.R609Q	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	890	Extracellular (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGGGATGACCGGACCATGAAT	0.552													A	160106465	A	A	160106465	3	1	104	1	0	0	0	0	1	0	0	0	1129	1116	39	2	2743	2	ATP1A2	1	160106465	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	137182134	160106465	89144156	3	7132											
SLC26A9	115019	broad.mit.edu	37	chr1	205897957	205897957	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggccacctggactcacccGcgttggatttctcccacgat	10	15	2	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr1:205897957G>A	uc001hdq.2	-	8	1065	c.951C>T	c.(949-951)CGC>CGT	p.R317R	SLC26A9_uc001hdo.2_5'Flank|SLC26A9_uc001hdp.2_Silent_p.R317R	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	317						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GGACTCACCCGCGTTGGATTT	0.577													A	205897957	A	A	205897957	2	1	104	1	0	0	0	0	0	0	0	1	14524	1074	38	1		1	SLC26A9	1	205897957	Silent	SNP	G	TCGA-06-6695-01A-11D-1845-08	45791492	205897957	43352664	4	7133											
RYR2	6262	broad.mit.edu	37	chr1	237659969	237659969	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgaaggatattctccctaccCtggagggggcgaagagtggg	16	8	1	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr1:237659969C>A	uc001hyl.1	+	20	2240	c.2120C>A	c.(2119-2121)CCT>CAT	p.P707H		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	707	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTCCCTACCCTGGAGGGGGC	0.507													A	237659969	A	A	237659969	3	1	104	1	0	0	0	0	1	0	0	0	13769	681	24	5	2198	5	RYR2	1	237659969	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	31762012	237659969	11590652	5	7134											
EPAS1	2034	broad.mit.edu	37	chr2	46608818	46608818	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caacaagctgaagctgaagcGacagctggagtatgaagagc	13	8	0	4			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr2:46608818G>A	uc002ruv.2	+	13	2617	c.2129G>A	c.(2128-2130)CGA>CAA	p.R710Q	EPAS1_uc002ruw.2_Missense_Mutation_p.R176Q	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	710					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			AAGCTGAAGCGACAGCTGGAG	0.617													A	46608818	A	A	46608818	3	1	104	1	0	0	0	0	1	0	0	0	5150	1058	37	2	2179	2	EPAS1	2	46608818	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08		46608818	196590555	6	7135											
GKN1	56287	broad.mit.edu	37	chr2	69207132	69207132	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgatgacctgagcaagttcGgaaaaaacattgcaaacatg	9	8	0	2	rs145566771		TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr2:69207132G>A	uc002sfc.2	+	5	508	c.445G>A	c.(445-447)GGA>AGA	p.G149R		NM_019617	NP_062563	Q9NS71	GKN1_HUMAN	18 kDa antrum mucosa protein precursor	149	BRICHOS.				digestion|positive regulation of cell division	extracellular region				breast(1)	1						GAGCAAGTTCGGAAAAAACAT	0.507													A	69207132	A	A	69207132	3	1	104	1	0	0	0	0	1	0	0	0	6424	1117	39	2	463	2	GKN1	2	69207132	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	22598314	69207132	173992241	7	7136											
YSK4	80122	broad.mit.edu	37	chr2	135745418	135745418	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atcctcttccctaactgcagGaatattgccttccttcaaat	4	13	2	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr2:135745418G>A	uc002tue.1	-	7	1055	c.1024C>T	c.(1024-1026)CCT>TCT	p.P342S	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.P229S|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.P70S|YSK4_uc002tui.3_Missense_Mutation_p.P359S	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	342							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTAACTGCAGGAATATTGCCT	0.368													A	135745418	A	A	135745418	3	1	104	1	0	0	0	0	1	0	0	0	17492	1174	41	3	2978	3	YSK4	2	135745418	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	66538286	135745418	107453955	8	7137											
RAPGEF4	11069	broad.mit.edu	37	chr2	173866027	173866027	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgactttattatgatgcactGtgtttttatgccaaataccc	6	8	0	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr2:173866027G>C	uc002uhv.3	+	17	1800	c.1613G>C	c.(1612-1614)TGT>TCT	p.C538S	RAPGEF4_uc002uhw.3_Missense_Mutation_p.C394S|RAPGEF4_uc010zec.1_Missense_Mutation_p.C385S|RAPGEF4_uc010zed.1_Missense_Mutation_p.C367S|RAPGEF4_uc010zee.1_Missense_Mutation_p.C385S|RAPGEF4_uc010fqo.2_Missense_Mutation_p.C367S|RAPGEF4_uc010zef.1_Missense_Mutation_p.C318S|RAPGEF4_uc010zeg.1_Missense_Mutation_p.C365S|RAPGEF4_uc010zeh.1_Missense_Mutation_p.C318S	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	538	N-terminal Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			ATGATGCACTGTGTTTTTATG	0.398													C	173866027	C	C	173866027	3	2	104	1	0	0	0	0	1	0	0	0	13046	1377	48	5	1695	5	RAPGEF4	2	173866027	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	38120609	173866027	69333346	9	7138											
GRIP2	80852	broad.mit.edu	37	chr3	14555293	14555293	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccattgatggacaggacacGgtcccccacctgcagcagcc	11	16	0	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr3:14555293G>A	uc011avi.1	-	14	1813	c.1813C>T	c.(1813-1815)CGT>TGT	p.R605C	GRIP2_uc010heh.2_RNA|GRIP2_uc011avh.1_Missense_Mutation_p.R136C	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	507	PDZ 4.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						GACAGGACACGGTCCCCCACC	0.647													A	14555293	A	A	14555293	3	1	104	1	0	0	0	0	1	0	0	0	6788	1116	39	2	1659	2	GRIP2	3	14555293	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08		14555293	183467137	10	7139											
SCN5A	6331	broad.mit.edu	37	chr3	38645338	38645338	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctttttgccatggagggcGtggccaggagccgaggttcc	15	10	1	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr3:38645338G>A	uc003cio.2	-	12	1949	c.1755C>T	c.(1753-1755)CAC>CAT	p.H585H	SCN5A_uc003cin.2_Silent_p.H585H|SCN5A_uc003cil.3_Silent_p.H585H|SCN5A_uc010hhi.2_Silent_p.H585H|SCN5A_uc010hhk.2_Silent_p.H585H|SCN5A_uc011ayr.1_Silent_p.H585H|SCN5A_uc010hhj.1_Silent_p.H196H	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	585					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CATGGAGGGCGTGGCCAGGAG	0.662													A	38645338	A	A	38645338	2	1	104	1	0	0	0	0	0	0	0	1	13922	1136	40	1		1	SCN5A	3	38645338	Silent	SNP	G	TCGA-06-6695-01A-11D-1845-08	24090045	38645338	159377092	11	7140											
CADPS	8618	broad.mit.edu	37	chr3	62423805	62423805	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	taacctttctatgtacatctCctcattgaccttatcacgca	3	13	4	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr3:62423805C>T	uc003dll.2	-	28	4111	c.3751G>A	c.(3751-3753)GAG>AAG	p.E1251K	CADPS_uc003dlj.1_Missense_Mutation_p.E206K|CADPS_uc003dlk.1_Missense_Mutation_p.E699K|CADPS_uc003dlm.2_Missense_Mutation_p.E1212K|CADPS_uc003dln.2_Missense_Mutation_p.E1172K	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1251	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ATGTACATCTCCTCATTGACC	0.458													T	62423805	T	T	62423805	3	4	104	1	0	0	0	0	1	0	0	0	2570	864	30	3	322	3	CADPS	3	62423805	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	23778467	62423805	135598625	12	7141											
ADCY5	111	broad.mit.edu	37	chr3	123008753	123008753	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagccatgtaggtgctgcCgatggtcttgatcttctcca	12	11	3	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr3:123008753C>T	uc003egh.1	-	19	3376	c.3376G>A	c.(3376-3378)GGC>AGC	p.G1126S	ADCY5_uc003egg.1_Missense_Mutation_p.G784S	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1126	Cytoplasmic (Potential).|Guanylate cyclase 2.				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TAGGTGCTGCCGATGGTCTTG	0.592													T	123008753	T	T	123008753	3	4	104	1	0	0	0	0	1	0	0	0	297	652	23	2	421	2	ADCY5	3	123008753	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	60584948	123008753	75013677	13	7142											
LRPAP1	4043	broad.mit.edu	37	chr4	3534104	3534104	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agcagtagcagcgccgggagCccgcgcagaaacgacctgac	14	14	0	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr4:3534104C>G	uc003ghi.2	-	1	121	c.36G>C	c.(34-36)GGG>GGC	p.G12G		NM_002337	NP_002328	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein	12					negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		GCGCCGGGAGCCCGCGCAGAA	0.706													G	3534104	G	G	3534104	2	3	104	1	0	0	0	0	0	0	0	1	8964	726	26	5		5	LRPAP1	4	3534104	Silent	SNP	C	TCGA-06-6695-01A-11D-1845-08		3534104	187620172	14	7143											
OTOP1	133060	broad.mit.edu	37	chr4	4190625	4190625	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gttgaccacaattatccaggGttcaaagccaaagacaatct	7	10	2	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr4:4190625G>T	uc003ghp.1	-	6	1774	c.1744C>A	c.(1744-1746)CCC>ACC	p.P582T		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	582	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ATTATCCAGGGTTCAAAGCCA	0.463													T	4190625	T	T	4190625	3	4	104	1	0	0	0	0	1	0	0	0	11305	1261	44	5	98	5	OTOP1	4	4190625	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	656521	4190625	186963651	15	7144											
ARHGAP10	79658	broad.mit.edu	37	chr4	148944421	148944421	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctttgttggaagatttttcGgacgccgcccgatactacat	10	10	0	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr4:148944421G>A	uc003ilf.2	+	19	1724	c.1724G>A	c.(1723-1725)CGG>CAG	p.R575Q	ARHGAP10_uc003ilg.2_Missense_Mutation_p.R224Q|ARHGAP10_uc003ilh.2_Missense_Mutation_p.R156Q|ARHGAP10_uc003ili.2_Missense_Mutation_p.R8Q	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	575					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		AAGATTTTTCGGACGCCGCCC	0.488													A	148944421	A	A	148944421	3	1	104	1	0	0	0	0	1	0	0	0	862	1116	39	2	1798	2	ARHGAP10	4	148944421	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	144753796	148944421	42209855	16	7145											
PIK3R1	5295	broad.mit.edu	37	chr5	67589149	67589151	+	In_Frame_Del	DEL	ATT	-	-													aggaaagggggaaataacaaAttaatcaaaatatttcatcg							TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr5:67589149_67589151delATT	uc003jva.2	+	10	1697_1699	c.1137_1139delATT	c.(1135-1140)AAATTA>AAA	p.L380del	PIK3R1_uc003jvb.2_In_Frame_Del_p.L380del|PIK3R1_uc003jvc.2_In_Frame_Del_p.L80del|PIK3R1_uc003jvd.2_In_Frame_Del_p.L110del|PIK3R1_uc003jve.2_In_Frame_Del_p.L59del|PIK3R1_uc011crb.1_In_Frame_Del_p.L50del	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	380	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.L380del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GAAATAACAAATTAATCAAAATA	0.305			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67589151	-	-	67589149	7	5	104	1	0	1	0	1	0	0	0	0	11918	98	4	0	1301	0	PIK3R1	5	67589149	In_Frame_Del	DEL	ATT	TCGA-06-6695-01A-11D-1845-08		67589149	113326111	17	7146											
PRR16	51334	broad.mit.edu	37	chr5	120021674	120021674	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgaccagattgacaccctgaCctctgacctacagctggagg	10	13	1	5			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr5:120021674C>A	uc003ksq.2	+	2	348	c.185C>A	c.(184-186)ACC>AAC	p.T62N	PRR16_uc003ksp.2_Missense_Mutation_p.T39N|PRR16_uc003ksr.2_5'UTR	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	62	Potential.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		GACACCCTGACCTCTGACCTA	0.443													A	120021674	A	A	120021674	3	1	104	1	0	0	0	0	1	0	0	0	12589	507	18	5	122	5	PRR16	5	120021674	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	52432525	120021674	60893586	18	7147											
MATR3	9782	broad.mit.edu	37	chr5	138658286	138658286	+	Splice_Site	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggtgtgtccttttgatttcaGaaaaagatcttactctccag	8	8	3	3			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr5:138658286G>A	uc003ldu.2	+	15	2206	c.1779_splice	c.e15-1	p.R593_splice	MATR3_uc010jfb.2_Splice_Site_p.R593_splice|MATR3_uc003ldt.2_Splice_Site_p.R255_splice|MATR3_uc003ldw.2_Splice_Site_p.R593_splice|MATR3_uc003ldx.2_Splice_Site_p.R593_splice|MATR3_uc010jfc.2_Splice_Site_p.R593_splice|MATR3_uc003ldy.2_Splice_Site_p.R270_splice|MATR3_uc011czb.1_Splice_Site_p.R305_splice|MATR3_uc003ldz.2_Splice_Site_p.R593_splice|MATR3_uc003lea.2_Splice_Site_p.R593_splice|MATR3_uc003leb.2_Splice_Site_p.R255_splice|MATR3_uc003lec.2_Splice_Site_p.R270_splice	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3							nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTTGATTTCAGAAAAAGATCT	0.338													A	138658286	A	A	138658286	5	1	104	1	0	0	0	0	0	0	1	0	9337	956	33	3	1820	3	MATR3	5	138658286	Splice_Site	SNP	G	TCGA-06-6695-01A-11D-1845-08	18636612	138658286	42256974	19	7148											
ARSI	340075	broad.mit.edu	37	chr5	149677472	149677472	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcagtgcccggcttgtccGttgctttcgcttgagcaggg	13	12	1	1	rs149628658	byFrequency	TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr5:149677472G>A	uc003lrv.2	-	2	1604	c.1015C>T	c.(1015-1017)CGG>TGG	p.R339W		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	339						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGGCTTGTCCGTTGCTTTCGC	0.627													A	149677472	A	A	149677472	3	1	104	1	0	0	0	0	1	0	0	0	994	1144	40	1	698	1	ARSI	5	149677472	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	11019186	149677472	31237788	20	7149											
FLT4	2324	broad.mit.edu	37	chr5	180041121	180041121	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaccacacgtcactctgcGtggtgtacaccttgtcgaag	11	12	2	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr5:180041121G>A	uc003mma.3	-	24	3357	c.3278C>T	c.(3277-3279)ACG>ATG	p.T1093M	FLT4_uc003mlz.3_Missense_Mutation_p.T1093M	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	1093	Cytoplasmic (Potential).|Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GTCACTCTGCGTGGTGTACAC	0.622									Congenital_Hereditary_Lymphedema				A	180041121	A	A	180041121	3	1	104	1	0	0	0	0	1	0	0	0	5944	1145	40	1	849	1	FLT4	5	180041121	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	30363649	180041121	874139	21	7150											
DNAH8	1769	broad.mit.edu	37	chr6	38704949	38704949	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcttgcaacaaacaactgggGtgctttaaaccagtccaagc	8	11	1	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr6:38704949G>T	uc003ooe.1	+	4	818	c.218G>T	c.(217-219)GGT>GTT	p.G73V		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AACAACTGGGGTGCTTTAAAC	0.353													T	38704949	T	T	38704949	3	4	104	1	0	0	0	0	1	0	0	0	4607	1261	44	5	224	5	DNAH8	6	38704949	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08		38704949	132410118	22	7151											
PKHD1	5314	broad.mit.edu	37	chr6	51900449	51900449	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagcgacattgatggcacaCgagtaagatccaaataatat	9	7	0	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr6:51900449C>T	uc003pah.1	-	28	3444	c.3168G>A	c.(3166-3168)TCG>TCA	p.S1056S	PKHD1_uc003pai.2_Silent_p.S1056S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1056	IPT/TIG 5.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TGATGGCACACGAGTAAGATC	0.453													T	51900449	T	T	51900449	2	4	104	1	0	0	0	0	0	0	0	1	11971	523	19	1		1	PKHD1	6	51900449	Silent	SNP	C	TCGA-06-6695-01A-11D-1845-08	13195500	51900449	119214618	23	7152											
KHDRBS2	202559	broad.mit.edu	37	chr6	62604661	62604661	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggcactggaagcgctccaCgggttacagtgcttccccga	13	13	0	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr6:62604661C>T	uc003peg.2	-	6	936	c.689G>A	c.(688-690)CGT>CAT	p.R230H		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	230	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		AAGCGCTCCACGGGTTACAGT	0.627													T	62604661	T	T	62604661	3	4	104	1	0	0	0	0	1	0	0	0	8147	536	19	1	376	1	KHDRBS2	6	62604661	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	10704212	62604661	108510406	24	7153											
BCKDHB	594	broad.mit.edu	37	chr6	80881059	80881059	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttgtcatgcatagaggatAaaaatccttgtatatttttt	6	4	1	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr6:80881059A>G	uc003pjd.2	+	6	761	c.694A>G	c.(694-696)AAA>GAA	p.K232E	BCKDHB_uc003pje.2_Missense_Mutation_p.K232E	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	232					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		CATAGAGGATAAAAATCCTTG	0.294													G	80881059	G	G	80881059	3	3	104	1	0	0	0	0	1	0	0	0	1360	363	13	4	716	4	BCKDHB	6	80881059	Missense_Mutation	SNP	A	TCGA-06-6695-01A-11D-1845-08	18276398	80881059	90234008	25	7154											
AIM1	202	broad.mit.edu	37	chr6	106999811	106999811	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	accagttttgaggactggggAggcaaaaattgtaagatctc	12	6	1	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr6:106999811A>T	uc003prh.2	+	12	4660	c.4173A>T	c.(4171-4173)GGA>GGT	p.G1391G	AIM1_uc003pri.2_Silent_p.G195G	NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1391	Beta/gamma crystallin 'Greek key' 8.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGGACTGGGGAGGCAAAAATT	0.338													T	106999811	T	T	106999811	2	4	104	1	0	0	0	0	0	0	0	1	430	291	11	5		5	AIM1	6	106999811	Silent	SNP	A	TCGA-06-6695-01A-11D-1845-08	26118752	106999811	64115256	26	7155											
C7orf36	57002	broad.mit.edu	37	chr7	39612016	39612016	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cactccaccgtcccatgttgTagatttattggactccattg	7	12	0	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr7:39612016T>C	uc003thc.3	+	3	401	c.392T>C	c.(391-393)GTA>GCA	p.V131A		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	131											0						TCCCATGTTGTAGATTTATTG	0.373													C	39612016	C	C	39612016	3	2	104	1	0	0	0	0	1	0	0	0	2390	1638	57	4	402	4	C7orf36	7	39612016	Missense_Mutation	SNP	T	TCGA-06-6695-01A-11D-1845-08		39612016	119526647	27	7156											
SPDYE1	285955	broad.mit.edu	37	chr7	44046879	44046879	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtcctcagctacctggccaaTgacatggaggaggacgacga	13	11	1	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr7:44046879T>C	uc003tjf.2	+	5	781	c.645T>C	c.(643-645)AAT>AAC	p.N215N	POLR2J4_uc003tjc.2_Intron|POLR2J4_uc003tjd.2_Intron|POLR2J4_uc010kxw.2_Intron|POLR2J4_uc003tje.3_Intron|uc003tjg.1_RNA	NM_175064	NP_778234	Q8NFV5	SPDE1_HUMAN	Williams Beuren syndrome chromosome region 19	215										ovary(1)	1						ACCTGGCCAATGACATGGAGG	0.567													C	44046879	C	C	44046879	2	2	104	1	0	0	0	0	0	0	0	1	15028	1461	51	4		4	SPDYE1	7	44046879	Silent	SNP	T	TCGA-06-6695-01A-11D-1845-08	4434863	44046879	115091784	28	7157											
EGFR	1956	broad.mit.edu	37	chr7	55249017	55249018	+	In_Frame_Ins	INS	-	CCACGT	CCACGT													atggccagcgtggacaacccINSccacgtgtgccgcctgctgg							TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr7:55249017_55249018insCCACGT	uc003tqk.2	+	20	2561_2562	c.2315_2316insCCACGT	c.(2314-2316)CCC>CCCCACGTC	p.774_775insHV	EGFR_uc010kzg.1_In_Frame_Ins_p.729_730insHV|EGFR_uc011kco.1_In_Frame_Ins_p.721_722insHV|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	774_775	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.H773_V774insNPH(12)|p.V774_C775insHV(4)|p.H773_V774insPH(3)|p.H773_V774insH(3)|p.V774M(3)|p.P772_H773insX(2)|p.N771_P772>SVDNR(1)|p.P772_H773insTHP(1)|p.H773_V774insGH(1)|p.H773_V774insG(1)|p.H773_V774insGNPH(1)|p.H773>NPY(1)|p.H773_V774>LM(1)|p.V774L(1)|p.P772P(1)|p.V774del(1)|p.D770_P772>ASVDNR(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGGACAACCCCCACGTGTGCC	0.644		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			CCACGT	55249018	CCACGT	CCACGT	55249017	7	5	104	1	0	1	1	0	0	0	0	0	4967	623	22	0	2657	0	EGFR	7	55249017	In_Frame_Ins	INS	-	TCGA-06-6695-01A-11D-1845-08	11202138	55249017	103889646	29	7158											
CLDN4	1364	broad.mit.edu	37	chr7	73245947	73245947	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatagtgccggtgtcctggaCggcccacaacatcatccaag	11	13	1	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr7:73245947C>T	uc003tzi.3	+	1	755	c.416C>T	c.(415-417)ACG>ATG	p.T139M	RFC2_uc011kfa.1_Intron|CLDN4_uc003tzh.1_RNA	NM_001305	NP_001296	O14493	CLD4_HUMAN	claudin 4	139	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)				GTGTCCTGGACGGCCCACAAC	0.632													T	73245947	T	T	73245947	3	4	104	1	0	0	0	0	1	0	0	0	3487	536	19	1	418	1	CLDN4	7	73245947	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	17996930	73245947	85892716	30	7159											
SAMD9	54809	broad.mit.edu	37	chr7	92733004	92733004	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aagatagacattatcttgttCttcaaaatcatcaacaagga	5	7	5	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr7:92733004C>T	uc003umf.2	-	3	2663	c.2407G>A	c.(2407-2409)GAA>AAA	p.E803K	SAMD9_uc003umg.2_Missense_Mutation_p.E803K	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	803						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTATCTTGTTCTTCAAAATCA	0.353													T	92733004	T	T	92733004	3	4	104	1	0	0	0	0	1	0	0	0	13826	922	32	3	2366	3	SAMD9	7	92733004	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	19487057	92733004	66405659	31	7160											
GIMAP4	55303	broad.mit.edu	37	chr7	150269429	150269429	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttgacacaccaggcattttcGacacagaggtgcccaatgct	9	12	0	2	rs137872040		TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr7:150269429G>A	uc003whl.2	+	3	353	c.271G>A	c.(271-273)GAC>AAC	p.D91N	GIMAP4_uc011kuu.1_Intron|GIMAP4_uc011kuv.1_Missense_Mutation_p.D105N	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	91							GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGCATTTTCGACACAGAGGT	0.507													A	150269429	A	A	150269429	3	1	104	1	0	0	0	0	1	0	0	0	6381	1058	37	2	277	2	GIMAP4	7	150269429	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	57536425	150269429	8869234	32	7161											
EPPK1	83481	broad.mit.edu	37	chr8	144940800	144940800	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtcgtcctccatgagctcttGcgtcgtgctccgtcccgttt	10	15	1	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr8:144940800G>C	uc003zaa.1	-	1	6635	c.6622C>G	c.(6622-6624)CAA>GAA	p.Q2208E		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2208						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ATGAGCTCTTGCGTCGTGCTC	0.622													C	144940800	C	C	144940800	3	2	104	1	0	0	0	0	1	0	0	0	5190	1328	46	5	644	5	EPPK1	8	144940800	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08		144940800	1423222	33	7162											
FAM75C1	441452	broad.mit.edu	37	chr9	90536103	90536103	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggtccaaaaatctcaggaCgtctttagtgtctccactcc	8	12	3	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr9:90536103C>T	uc010mqi.2	+	4	1310	c.1281C>T	c.(1279-1281)GAC>GAT	p.D427D	FAM75C1_uc004apq.3_Silent_p.D410D	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						AATCTCAGGACGTCTTTAGTG	0.493													T	90536103	T	T	90536103	2	4	104	1	0	0	0	0	0	0	0	1	5623	535	19	1		1	FAM75C1	9	90536103	Silent	SNP	C	TCGA-06-6695-01A-11D-1845-08		90536103	50677328	34	7163											
GFI1B	8328	broad.mit.edu	37	chr9	135866288	135866288	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcacaagtgccaggtgtgcGgaaaggccttcagccagagc	14	12	1	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr9:135866288G>A	uc004ccg.2	+	7	995	c.844G>A	c.(844-846)GGA>AGA	p.G282R	GFI1B_uc010mzy.2_Missense_Mutation_p.G236R	NM_004188	NP_004179	Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription	282	C2H2-type 5.|Mediates interaction with GATA1.|Interaction with ARIH2.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		CCAGGTGTGCGGAAAGGCCTT	0.647													A	135866288	A	A	135866288	3	1	104	1	0	0	0	0	1	0	0	0	6340	1117	39	2	866	2	GFI1B	9	135866288	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	45330185	135866288	5347143	35	7164											
ADARB2	105	broad.mit.edu	37	chr10	1284235	1284235	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtagaggaagtgcaggaaCgcccgccgggccacgacctc	15	13	0	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr10:1284235C>T	uc009xhq.2	-	5	1694	c.1320G>A	c.(1318-1320)GCG>GCA	p.A440A		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	440	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		AGTGCAGGAACGCCCGCCGGG	0.706													T	1284235	T	T	1284235	2	4	104	1	0	0	0	0	0	0	0	1	283	523	19	1		1	ADARB2	10	1284235	Silent	SNP	C	TCGA-06-6695-01A-11D-1845-08		1284235	134250512	36	7165											
C10orf71	118461	broad.mit.edu	37	chr10	50530623	50530623	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aataagaagtgcacagacgcGttcagcgactcctccagcat	9	12	1	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr10:50530623G>A	uc010qgp.1	+	3	372	c.33G>A	c.(31-33)GCG>GCA	p.A11A		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	11											0						GCACAGACGCGTTCAGCGACT	0.542													A	50530623	A	A	50530623	2	1	104	1	0	0	0	0	0	0	0	1	1614	1132	40	1		1	C10orf71	10	50530623	Silent	SNP	G	TCGA-06-6695-01A-11D-1845-08	49246388	50530623	85004124	37	7166											
ANK3	288	broad.mit.edu	37	chr10	62149275	62149275	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taaatccctgtttttctttaAttgtgaggctgcatgagcca	8	8	1	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr10:62149275A>C	uc001jky.2	-	1	214	c.22T>G	c.(22-24)TTA>GTA	p.L8V	ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	8					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTTTTCTTTAATTGTGAGGCT	0.423													C	62149275	C	C	62149275	3	2	104	1	0	0	0	0	1	0	0	0	622	98	4	5	13616	5	ANK3	10	62149275	Missense_Mutation	SNP	A	TCGA-06-6695-01A-11D-1845-08	11618652	62149275	73385472	38	7167											
ECHS1	1892	broad.mit.edu	37	chr10	135183513	135183513	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctggaaactcaggttctgCatttccttgatatcagctcc	7	12	3	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr10:135183513C>T	uc001lmu.2	-	3	380	c.309G>A	c.(307-309)ATG>ATA	p.M103I		NM_004092	NP_004083	P30084	ECHM_HUMAN	mitochondrial short-chain enoyl-coenzyme A	103					fatty acid beta-oxidation	mitochondrial matrix	enoyl-CoA hydratase activity|protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;1.62e-06)|OV - Ovarian serous cystadenocarcinoma(35;5.75e-06)|Epithelial(32;7.58e-06)		TCAGGTTCTGCATTTCCTTGA	0.517													T	135183513	T	T	135183513	3	4	104	1	0	0	0	0	1	0	0	0	4896	710	25	3	587	3	ECHS1	10	135183513	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	73034238	135183513	351234	39	7168											
KBTBD4	55709	broad.mit.edu	37	chr11	47594600	47594600	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccccctttttatatcggtccCggaagacatagatgctcccg	8	14	0	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr11:47594600C>G	uc001nfx.2	-	4	1610	c.1439G>C	c.(1438-1440)CGG>CCG	p.R480P	PTPMT1_uc001nfs.3_3'UTR|PTPMT1_uc001nfv.3_3'UTR|PTPMT1_uc009ylt.2_3'UTR|PTPMT1_uc001nfu.3_3'UTR|NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_Missense_Mutation_p.R505P|KBTBD4_uc001nfz.2_Missense_Mutation_p.R496P|KBTBD4_uc001nfy.2_Missense_Mutation_p.R480P	NM_016506	NP_057590	Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	480	Kelch 5.									ovary(1)|central_nervous_system(1)	2						ATATCGGTCCCGGAAGACATA	0.527													G	47594600	G	G	47594600	3	3	104	1	0	0	0	0	1	0	0	0	7995	652	23	5	121	5	KBTBD4	11	47594600	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08		47594600	87411916	40	7169											
OR5AR1	219493	broad.mit.edu	37	chr11	56432005	56432005	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgttctacacggttatcAtccccatgttaaatcccttg	6	12	2	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr11:56432005A>G	uc010rjm.1	+	1	844	c.844A>G	c.(844-846)ATC>GTC	p.I282V		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACGGTTATCATCCCCATGTT	0.423													G	56432005	G	G	56432005	3	3	104	1	0	0	0	0	1	0	0	0	11145	217	8	4	846	4	OR5AR1	11	56432005	Missense_Mutation	SNP	A	TCGA-06-6695-01A-11D-1845-08	8837405	56432005	78574511	41	7170											
PRSS23	11098	broad.mit.edu	37	chr11	86519032	86519032	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggagatggggcccaacaccGagactcagggtcttcaggaa	14	10	3	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr11:86519032G>A	uc001pcb.2	+	2	563	c.347G>A	c.(346-348)CGA>CAA	p.R116Q	PRSS23_uc001pcc.1_Intron|PRSS23_uc010rts.1_Missense_Mutation_p.R84Q	NM_007173	NP_009104	O95084	PRS23_HUMAN	protease, serine, 23 precursor	116					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCCCAACACCGAGACTCAGGG	0.517													A	86519032	A	A	86519032	3	1	104	1	0	0	0	0	1	0	0	0	12620	1058	37	2	349	2	PRSS23	11	86519032	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	30087027	86519032	48487484	42	7171											
PVRL1	5818	broad.mit.edu	37	chr11	119510587	119510587	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctcacccggccccatccGtctccggtgggctcttctgc	11	18	4	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr11:119510587G>A	uc001pwu.1	-	6	1311	c.1139C>T	c.(1138-1140)ACG>ATG	p.T380M		NM_203285	NP_976030	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 2	Error:Variant_position_missing_in_Q15223_after_alignment					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GGCCCCATCCGTCTCCGGTGG	0.622													A	119510587	A	A	119510587	3	1	104	1	0	0	0	0	1	0	0	0	12839	1145	40	1	249	1	PVRL1	11	119510587	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	32991555	119510587	15495929	43	7172											
KIRREL3	84623	broad.mit.edu	37	chr11	126343282	126343282	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaggcttggcattgtctgcGtggcaggtgaggttgagagg	19	6	1	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr11:126343282G>A	uc001qea.2	-	5	874	c.513C>T	c.(511-513)CAC>CAT	p.H171H	KIRREL3_uc001qeb.2_Silent_p.H171H|KIRREL3_uc001qec.1_Silent_p.H171H	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	171	Ig-like C2-type 2.|Extracellular (Potential).				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CATTGTCTGCGTGGCAGGTGA	0.587													A	126343282	A	A	126343282	2	1	104	1	0	0	0	0	0	0	0	1	8326	1136	40	1		1	KIRREL3	11	126343282	Silent	SNP	G	TCGA-06-6695-01A-11D-1845-08	6832695	126343282	8663234	44	7173											
A2M	2	broad.mit.edu	37	chr12	9230302	9230302	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccagaatgattcacctttaTggcattgttgagcagtgacc	9	9	1	4			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr12:9230302T>C	uc001qvk.1	-	26	3384	c.3271A>G	c.(3271-3273)ATA>GTA	p.I1091V	A2M_uc001qvj.1_Missense_Mutation_p.I133V|A2M_uc009zgk.1_Missense_Mutation_p.I941V	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1091					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TTCACCTTTATGGCATTGTTG	0.443													C	9230302	C	C	9230302	3	2	104	1	0	0	0	0	1	0	0	0	4	1464	51	4	1197	4	A2M	12	9230302	Missense_Mutation	SNP	T	TCGA-06-6695-01A-11D-1845-08		9230302	124621593	45	7174											
PZP	5858	broad.mit.edu	37	chr12	9345184	9345184	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgtgccgtgatagtctccGtgtggccacagggcagggta	16	9	1	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr12:9345184G>A	uc001qvl.2	-	12	1435	c.1406C>T	c.(1405-1407)ACG>ATG	p.T469M	PZP_uc009zgl.2_Missense_Mutation_p.T338M	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						GATAGTCTCCGTGTGGCCACA	0.512													A	9345184	A	A	9345184	3	1	104	1	0	0	0	0	1	0	0	0	12869	1145	40	1	3142	1	PZP	12	9345184	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	114882	9345184	124506711	46	7175											
KLRC1	3821	broad.mit.edu	37	chr12	10600149	10600149	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcatgtttgaaagccaaaCcattcattgtcacccatgga	6	11	3	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr12:10600149C>T	uc001qyl.2	-	6	736	c.572G>A	c.(571-573)GGT>GAT	p.G191D	KLRC1_uc009zhm.1_Missense_Mutation_p.G191D|KLRC1_uc001qym.2_Missense_Mutation_p.G173D|KLRC1_uc001qyn.2_Missense_Mutation_p.G191D|KLRC1_uc001qyo.2_Missense_Mutation_p.G173D	NM_002259	NP_002250	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C,	191	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						GAAAGCCAAACCATTCATTGT	0.323													T	10600149	T	T	10600149	3	4	104	1	0	0	0	0	1	0	0	0	8415	507	18	3	137	3	KLRC1	12	10600149	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	1254965	10600149	123251746	47	7176											
LRRK2	120892	broad.mit.edu	37	chr12	40715936	40715936	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggatctgaagtcttagacaAtcatccagagagtttcttaa	8	7	4	3			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr12:40715936A>G	uc001rmg.3	+	36	5391	c.5270A>G	c.(5269-5271)AAT>AGT	p.N1757S	LRRK2_uc009zjw.2_Missense_Mutation_p.N595S|LRRK2_uc001rmi.2_Missense_Mutation_p.N590S	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1757					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GTCTTAGACAATCATCCAGAG	0.353													G	40715936	G	G	40715936	3	3	104	1	0	0	0	0	1	0	0	0	9033	101	4	4	5412	4	LRRK2	12	40715936	Missense_Mutation	SNP	A	TCGA-06-6695-01A-11D-1845-08	30115787	40715936	93135959	48	7177											
COL2A1	1280	broad.mit.edu	37	chr12	48372465	48372465	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcaccagctcggccagggGggccgctgtctcctcgagca	14	15	2	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr12:48372465G>A	uc001rqu.2	-	42	2991	c.2810C>T	c.(2809-2811)CCC>CTC	p.P937L	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.P868L	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	937	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TCGGCCAGGGGGGCCGCTGTC	0.632													A	48372465	A	A	48372465	3	1	104	1	0	0	0	0	1	0	0	0	3687	1232	43	3	1705	3	COL2A1	12	48372465	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	7656529	48372465	85479430	49	7178											
WNT1	7471	broad.mit.edu	37	chr12	49374347	49374348	+	Frame_Shift_Ins	INS	-	G	G													cgggggccccgactggcactINSgggggggctgcagcgacaac							TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr12:49374347_49374348insG	uc001rsu.2	+	3	697_698	c.499_500insG	c.(499-501)TGGfs	p.W167fs		NM_005430	NP_005421	P04628	WNT1_HUMAN	wingless-type MMTV integration site family,	167					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			kidney(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.244)		cgACTGGCACTGGGGGGGCTGC	0.554													G	49374348	G	G	49374347	7	5	104	1	0	1	1	0	0	0	0	0	17378	1580	55	0	509	0	WNT1	12	49374347	Frame_Shift_Ins	INS	-	TCGA-06-6695-01A-11D-1845-08	1001882	49374347	84477548	50	7179											
PA2G4	5036	broad.mit.edu	37	chr12	56505022	56505022	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatgcccaatggccccatgCggataaccagtggtcccttc	9	15	1	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr12:56505022C>T	uc001sjm.2	+	11	1413	c.994C>T	c.(994-996)CGG>TGG	p.R332W	PA2G4_uc009zol.2_Missense_Mutation_p.R332W|PA2G4_uc009zom.2_Intron	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	332	Necessary for nucleolar localization.				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			TGGCCCCATGCGGATAACCAG	0.438													T	56505022	T	T	56505022	3	4	104	1	0	0	0	0	1	0	0	0	11361	759	27	1	1036	1	PA2G4	12	56505022	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	7130675	56505022	77346873	51	7180											
GRIP1	23426	broad.mit.edu	37	chr12	66788078	66788078	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtgatgccaaggggccccCcgtagcgtttaagctccacg	12	13	0	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr12:66788078C>T	uc001stk.2	-	16	2124	c.1883G>A	c.(1882-1884)GGG>GAG	p.G628E	GRIP1_uc010sta.1_Missense_Mutation_p.G572E|GRIP1_uc001stj.2_Missense_Mutation_p.G410E|GRIP1_uc001stl.1_Missense_Mutation_p.G520E|GRIP1_uc001stm.2_Missense_Mutation_p.G628E	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	680	PDZ 6.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		AAGGGGCCCCCCGTAGCGTTT	0.413													T	66788078	T	T	66788078	3	4	104	1	0	0	0	0	1	0	0	0	6787	623	22	3	1383	3	GRIP1	12	66788078	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	10283056	66788078	67063817	52	7181											
COL4A1	1282	broad.mit.edu	37	chr13	110819539	110819539	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actcctggaggccccatatcAcccttagagcctgtgattcc	8	15	1	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr13:110819539A>C	uc001vqw.3	-	44	4037	c.3915T>G	c.(3913-3915)GGT>GGG	p.G1305G	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1305	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GCCCCATATCACCCTTAGAGC	0.507													C	110819539	C	C	110819539	2	2	104	1	0	0	0	0	0	0	0	1	3689	146	6	5		5	COL4A1	13	110819539	Silent	SNP	A	TCGA-06-6695-01A-11D-1845-08		110819539	4350339	53	7182											
AHNAK2	113146	broad.mit.edu	37	chr14	105409917	105409917	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggccgtcatgtccttgtcGgccagggacaggtccccctc	12	15	1	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr14:105409917G>A	uc010axc.1	-	7	11991	c.11871C>T	c.(11869-11871)GCC>GCT	p.A3957A	AHNAK2_uc001ypx.2_Silent_p.A3857A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3957						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGTCCTTGTCGGCCAGGGACA	0.622													A	105409917	A	A	105409917	2	1	104	1	0	0	0	0	0	0	0	1	415	1103	39	2		2	AHNAK2	14	105409917	Silent	SNP	G	TCGA-06-6695-01A-11D-1845-08		105409917	1939623	54	7183											
LRRK1	79705	broad.mit.edu	37	chr15	101464858	101464859	+	Frame_Shift_Ins	INS	-	C	C													tggctggcatgtcgcaaagaINSccccccagcatgtactggtg							TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr15:101464858_101464859insC	uc002bwr.2	+	2	340_341	c.21_22insC	c.(19-24)AGACCCfs	p.R7fs	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bwq.1_Frame_Shift_Ins_p.R7fs	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	7_8					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTCGCAAAGACCCCCCAGCAT	0.594													C	101464859	C	C	101464858	7	5	104	1	0	1	1	0	0	0	0	0	9032	272	10	0	23	0	LRRK1	15	101464858	Frame_Shift_Ins	INS	-	TCGA-06-6695-01A-11D-1845-08		101464858	1066534	55	7184											
AXIN1	8312	broad.mit.edu	37	chr16	347056	347056	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gctgcgtgcggggtgctcacCcgtggccggtcctgcggtgc	18	14	1	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr16:347056C>G	uc002cgp.1	-	7	2132	c.1955G>C	c.(1954-1956)GGG>GCG	p.G652A	AXIN1_uc002cgq.1_Missense_Mutation_p.G652A	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	652	Interaction with RNF111.|Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GGGTGCTCACCCGTGGCCGGT	0.627													G	347056	G	G	347056	3	3	104	1	0	0	0	0	1	0	0	0	1236	637	22	5	653	5	AXIN1	16	347056	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08		347056	90007697	56	7185											
ERCC4	2072	broad.mit.edu	37	chr16	14041971	14041971	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagattctgaaacccttcccGagtcagagaagtataatcct	7	11	2	3			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr16:14041971G>A	uc002dce.2	+	11	2527	c.2518G>A	c.(2518-2520)GAG>AAG	p.E840K	ERCC4_uc010uyz.1_Missense_Mutation_p.E390K	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	840	Interaction with EME1 and ERCC1.				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						AACCCTTCCCGAGTCAGAGAA	0.498			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				A	14041971	A	A	14041971	3	1	104	1	0	0	0	0	1	0	0	0	5215	1059	37	2	2560	2	ERCC4	16	14041971	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	13694915	14041971	76312782	57	7186											
PLCG2	5336	broad.mit.edu	37	chr16	81953271	81953271	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cctggagcgctacaatatggTaggtggtggactcccttgtg	14	9	0	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr16:81953271T>A	uc002fgt.2	+	20	2387	c.2235_splice	c.e20+2	p.M745_splice	PLCG2_uc010chg.1_Splice_Site_p.M745_splice	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2						intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TACAATATGGTAGGTGGTGGA	0.418													A	81953271	A	A	81953271	5	1	104	1	0	0	0	0	0	0	1	0	12036	1652	57	5	2311	5	PLCG2	16	81953271	Splice_Site	SNP	T	TCGA-06-6695-01A-11D-1845-08	67911300	81953271	8401482	58	7187											
ANKRD11	29123	broad.mit.edu	37	chr16	89347130	89347130	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctcctcggtgatgacggcGctgaagggaccctcgtccag	15	13	0	3			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr16:89347130G>A	uc002fmx.1	-	9	6281	c.5820C>T	c.(5818-5820)AGC>AGT	p.S1940S	ANKRD11_uc002fmy.1_Silent_p.S1940S|ANKRD11_uc002fnc.1_Silent_p.S1940S|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Silent_p.S1897S	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1940	Pro-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TGATGACGGCGCTGAAGGGAC	0.692													A	89347130	A	A	89347130	2	1	104	1	0	0	0	0	0	0	0	1	639	1078	38	1		1	ANKRD11	16	89347130	Silent	SNP	G	TCGA-06-6695-01A-11D-1845-08	7393859	89347130	1007623	59	7188											
OR3A2	4995	broad.mit.edu	37	chr17	3181517	3181517	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctttcggccctccactgaaCggattcgtagaactgcagct	9	13	1	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr17:3181517C>T	uc002fvg.2	-	1	752	c.713G>A	c.(712-714)CGT>CAT	p.R238H		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	238	Cytoplasmic (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CTCCACTGAACGGATTCGTAG	0.527													T	3181517	T	T	3181517	3	4	104	1	0	0	0	0	1	0	0	0	11038	536	19	1	256	1	OR3A2	17	3181517	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08		3181517	78013693	60	7189											
C19orf35	374872	broad.mit.edu	37	chr19	2278840	2278840	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagggagaggcccagtggggCgtcagccgggccaaaggtca	19	10	2	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr19:2278840C>T	uc002lvn.2	-	3	455	c.355G>A	c.(355-357)GCC>ACC	p.A119T	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	119										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGTGGGGCGTCAGCCGGG	0.677													T	2278840	T	T	2278840	3	4	104	1	0	0	0	0	1	0	0	0	1920	768	27	1	1074	1	C19orf35	19	2278840	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08		2278840	56850143	61	7190											
TNFSF9	8744	broad.mit.edu	37	chr19	6535006	6535006	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggcagcttacccagggcGccacagtcttgggactcttc	11	15	2	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr19:6535006G>A	uc002mfh.2	+	3	732	c.694G>A	c.(694-696)GCC>ACC	p.A232T		NM_003811	NP_003802	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily,	232	Extracellular (Potential).				apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						TACCCAGGGCGCCACAGTCTT	0.662													A	6535006	A	A	6535006	3	1	104	1	0	0	0	0	1	0	0	0	16309	1087	38	1	704	1	TNFSF9	19	6535006	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	4256166	6535006	52593977	62	7191											
TNPO2	30000	broad.mit.edu	37	chr19	12813636	12813636	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagccgggccaggtgcccaCctgtgttttccagcagtgtc	13	14	0	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr19:12813636C>T	uc002muo.2	-	20	2490	c.2305_splice	c.e20+1	p.G769_splice	TNPO2_uc002mup.2_Splice_Site_p.A861_splice|TNPO2_uc002muq.2_Splice_Site_p.A769_splice|TNPO2_uc002mur.2_Splice_Site_p.A769_splice	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)						intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						CAGGTGCCCACCTGTGTTTTC	0.582													T	12813636	T	T	12813636	5	4	104	1	0	0	0	0	0	0	1	0	16333	521	18	3	407	3	TNPO2	19	12813636	Splice_Site	SNP	C	TCGA-06-6695-01A-11D-1845-08	6278630	12813636	46315347	63	7192											
KIR3DL1	3811	broad.mit.edu	37	chr19	55327961	55327961	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaccggcagcaccatgtcGctcatggtcgtcagcatggc	12	14	2	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr19:55327961G>A	uc002qhk.3	+	1	69	c.6G>A	c.(4-6)TCG>TCA	p.S2S	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_5'UTR|KIR3DL1_uc010esf.2_Silent_p.S2S|KIR3DL1_uc010yfo.1_5'UTR|KIR3DL1_uc002qhl.3_Silent_p.S2S	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	2					immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GCACCATGTCGCTCATGGTCG	0.597											OREG0003676	type=REGULATORY REGION|Gene=KIR3DL1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	A	55327961	A	A	55327961	2	1	104	1	0	0	0	0	0	0	0	1	8320	1074	38	1		1	KIR3DL1	19	55327961	Silent	SNP	G	TCGA-06-6695-01A-11D-1845-08	42514325	55327961	3801022	64	7193											
HCK	3055	broad.mit.edu	37	chr20	30674579	30674579	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggtggtcaccaaggagccCatctacatcatcacggagtt	11	12	4	0			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr20:30674579C>T	uc002wxh.2	+	9	1155	c.984C>T	c.(982-984)CCC>CCT	p.P328P	HCK_uc010gdy.2_Silent_p.P307P|HCK_uc002wxi.2_Silent_p.P306P	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	328	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCAAGGAGCCCATCTACATCA	0.587													T	30674579	T	T	30674579	2	4	104	1	0	0	0	0	0	0	0	1	6994	581	21	3		3	HCK	20	30674579	Silent	SNP	C	TCGA-06-6695-01A-11D-1845-08		30674579	32350941	65	7194											
PLUNC	51297	broad.mit.edu	37	chr20	31829275	31829275	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgagttggttcagggcaaCgtaagtaggcaaggtgggga	17	6	1	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr20:31829275C>T	uc002wyv.2	+	6	736	c.666C>T	c.(664-666)AAC>AAT	p.N222N	PLUNC_uc002wyt.3_Silent_p.N222N|PLUNC_uc002wyu.3_Silent_p.N222N	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	222					innate immune response	extracellular region	lipid binding				0						TTCAGGGCAACGTAAGTAGGC	0.502													T	31829275	T	T	31829275	2	4	104	1	0	0	0	0	0	0	0	1	12115	550	19	1		1	PLUNC	20	31829275	Silent	SNP	C	TCGA-06-6695-01A-11D-1845-08	1154696	31829275	31196245	66	7195											
DUSP18	150290	broad.mit.edu	37	chr22	31059768	31059768	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcacagagacgtgagttagGggagtcagccacaggtacct	14	9	2	2			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr22:31059768G>A	uc003aiu.2	-	2	724	c.223C>T	c.(223-225)CCT>TCT	p.P75S	SLC35E4_uc003ait.2_Intron|DUSP18_uc010gwa.1_Intron|DUSP18_uc003aiw.1_Missense_Mutation_p.P75S	NM_152511	NP_689724	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	75						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						CGTGAGTTAGGGGAGTCAGCC	0.507													A	31059768	A	A	31059768	3	1	104	1	0	0	0	0	1	0	0	0	4817	1232	43	3	347	3	DUSP18	22	31059768	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08		31059768	20244798	67	7196											
CYP2D6	1565	broad.mit.edu	37	chr22	42525154	42525154	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggagaagcgcctctgctcgCgccacgcgggcccatagcgc	14	17	1	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr22:42525154C>T	uc003bce.2	-	3	476	c.386G>A	c.(385-387)CGC>CAC	p.R129H	uc003bcd.1_Intron|CYP2D6_uc010gyu.2_Intron|CYP2D6_uc003bcf.2_Intron	NM_000106	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D,	129							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			breast(1)|skin(1)	2						CCTCTGCTCGCGCCACGCGGG	0.687													T	42525154	T	T	42525154	3	4	104	1	0	0	0	0	1	0	0	0	4169	768	27	1	1135	1	CYP2D6	22	42525154	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08	11465386	42525154	8779412	68	7197											
MOV10L1	54456	broad.mit.edu	37	chr22	50581577	50581577	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattctgagtggtgactgccGtcccctcccgtatattctct	9	13	2	2	rs140536899		TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chr22:50581577G>A	uc003bjj.2	+	17	2368	c.2285G>A	c.(2284-2286)CGT>CAT	p.R762H	MOV10L1_uc003bjk.3_Missense_Mutation_p.R762H|MOV10L1_uc011arp.1_Missense_Mutation_p.R742H|MOV10L1_uc011arq.1_Missense_Mutation_p.R523H	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	762					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GGTGACTGCCGTCCCCTCCCG	0.468													A	50581577	A	A	50581577	3	1	104	1	0	0	0	0	1	0	0	0	9719	1145	40	1	2392	1	MOV10L1	22	50581577	Missense_Mutation	SNP	G	TCGA-06-6695-01A-11D-1845-08	8056423	50581577	722989	69	7198											
IL13RA2	3598	broad.mit.edu	37	chrX	114249014	114249014	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatccaataagtagtttctgCccaggaactttgaacttctg	7	9	2	1			TCGA-06-6695-01A-11D-1845-08	TCGA-06-6695-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	13817acd-8c1e-4154-8b88-7cdc5f2660a7	360150fc-e84a-423e-bfdb-fa9b487758e3	g.chrX:114249014C>T	uc004epx.2	-	4	495	c.370G>A	c.(370-372)GCA>ACA	p.A124T	IL13RA2_uc010nqd.1_Missense_Mutation_p.A124T	NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	124	Extracellular (Potential).|Fibronectin type-III 1.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3						GTAGTTTCTGCCCAGGAACTT	0.363													T	114249014	T	T	114249014	3	4	104	1	0	0	0	0	1	0	0	0	7630	739	26	3	800	3	IL13RA2	23	114249014	Missense_Mutation	SNP	C	TCGA-06-6695-01A-11D-1845-08		114249014	41021546	70	7199											
PRAMEF2	65122	broad.mit.edu	37	chr1	12919080	12919080	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggtatcgctgatgaagacGcttcatctggagccattgaa	11	9	2	4			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:12919080G>A	uc001aum.1	+	2	303	c.216G>A	c.(214-216)ACG>ACA	p.T72T		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	72											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGATGAAGACGCTTCATCTGG	0.552													A	12919080	A	A	12919080	2	1	105	1	0	0	0	0	0	0	0	1	12435	1074	38	1		1	PRAMEF2	1	12919080	Silent	SNP	G	TCGA-06-6697-01A-11D-1845-08		12919080	236331541	1	7200											
SPEN	23013	broad.mit.edu	37	chr1	16199442	16199442	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ggtcaacaaaatgggtgacaGagacctacgcacggattata	11	8	1	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:16199442G>C	uc001axk.1	+	2	419	c.215G>C	c.(214-216)AGA>ACA	p.R72T	SPEN_uc010obp.1_5'Flank	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	72	By similarity.|RRM 1.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ATGGGTGACAGAGACCTACGC	0.493													C	16199442	C	C	16199442	3	2	105	1	0	0	0	0	1	0	0	0	15037	942	33	5	221	5	SPEN	1	16199442	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	3280362	16199442	233051179	2	7201											
TCEA3	6920	broad.mit.edu	37	chr1	23720438	23720438	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcacgttccgccgcaggccGgggttcctggggtccttgag	16	13	0	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:23720438G>A	uc001bgx.1	-	8	888	c.753C>T	c.(751-753)CCC>CCT	p.P251P	TCEA3_uc009vqm.1_Silent_p.P20P	NM_003196	NP_003187	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	251	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		GCCGCAGGCCGGGGTTCCTGG	0.597													A	23720438	A	A	23720438	2	1	105	1	0	0	0	0	0	0	0	1	15666	1103	39	2		2	TCEA3	1	23720438	Silent	SNP	G	TCGA-06-6697-01A-11D-1845-08	7520996	23720438	225530183	3	7202											
MPL	4352	broad.mit.edu	37	chr1	43817970	43817970	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagggacactgcagccctgaGcccggtgagtgtgcttccct	13	13	0	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:43817970G>A	uc001ciw.2	+	11	1694	c.1649G>A	c.(1648-1650)AGC>AAC	p.S550N	MPL_uc009vwr.2_Missense_Mutation_p.S543N	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	550	Cytoplasmic (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCAGCCCTGAGCCCGGTGAGT	0.607			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						A	43817970	A	A	43817970	3	1	105	1	0	0	0	0	1	0	0	0	9730	971	34	3	1691	3	MPL	1	43817970	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	20097532	43817970	205432651	4	7203											
DAB1	1600	broad.mit.edu	37	chr1	57480758	57480758	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccatctggaaatccttaaaCgtttctttgcccattttctg	6	11	3	0	rs147876561	byFrequency	TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:57480758C>T	uc001cys.1	-	14	1916	c.1242G>A	c.(1240-1242)ACG>ACA	p.T414T	DAB1_uc001cyt.1_Silent_p.T412T|DAB1_uc001cyq.1_Silent_p.T412T|DAB1_uc001cyr.1_Silent_p.T328T|DAB1_uc009vzw.1_Silent_p.T396T|DAB1_uc009vzx.1_Silent_p.T414T	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	447					cell differentiation|nervous system development					skin(2)|ovary(1)	3						AATCCTTAAACGTTTCTTTGC	0.602													T	57480758	T	T	57480758	2	4	105	1	0	0	0	0	0	0	0	1	4217	523	19	1		1	DAB1	1	57480758	Silent	SNP	C	TCGA-06-6697-01A-11D-1845-08	13662788	57480758	191769863	5	7204											
DCLRE1B	64858	broad.mit.edu	37	chr1	114454524	114454524	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	attttcagtgcacttaaggtCtacagatgaggagtttattt	9	5	2	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:114454524C>G	uc001eeg.2	+	4	1481	c.1310C>G	c.(1309-1311)TCT>TGT	p.S437C	DCLRE1B_uc001eeh.2_Intron|DCLRE1B_uc001eei.2_Missense_Mutation_p.S311C	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	437					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACTTAAGGTCTACAGATGAG	0.473								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					G	114454524	G	G	114454524	3	3	105	1	0	0	0	0	1	0	0	0	4295	913	32	5	1324	5	DCLRE1B	1	114454524	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	56973766	114454524	134796097	6	7205											
CD1D	912	broad.mit.edu	37	chr1	158151257	158151257	+	Frame_Shift_Del	DEL	T	-	-													tctcccagtcccgcaaaggcTtttccccctccgctgcctcc							TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:158151257delT	uc001frr.2	+	3	573	c.74delT	c.(73-75)CTTfs	p.L25fs	CD1D_uc009wsr.1_Frame_Shift_Del_p.L25fs|CD1D_uc009wss.2_Frame_Shift_Del_p.L25fs|CD1D_uc009wst.1_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	25	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CCGCAAAGGCTTTTCCCCCTC	0.592													-	158151257	-	-	158151257	7	5	105	1	0	1	0	1	0	0	0	0	2977	1609	56	0	80	0	CD1D	1	158151257	Frame_Shift_Del	DEL	T	TCGA-06-6697-01A-11D-1845-08	43696733	158151257	91099364	7	7206											
CRB1	23418	broad.mit.edu	37	chr1	197313558	197313558	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	actcaacactgatgagtgtgCcagtcaaccttgtctccatg	8	12	3	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:197313558C>A	uc001gtz.2	+	3	935	c.800C>A	c.(799-801)GCC>GAC	p.A267D	CRB1_uc010poz.1_Missense_Mutation_p.A198D|CRB1_uc001gty.1_Missense_Mutation_p.A267D|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Intron|CRB1_uc010ppb.1_Missense_Mutation_p.A267D|CRB1_uc010ppc.1_RNA	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	267	Extracellular (Potential).|EGF-like 7; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GATGAGTGTGCCAGTCAACCT	0.512													A	197313558	A	A	197313558	3	1	105	1	0	0	0	0	1	0	0	0	3848	739	26	5	810	5	CRB1	1	197313558	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	39162301	197313558	51937063	8	7207											
IGFN1	91156	broad.mit.edu	37	chr1	201190709	201190709	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agctgtgcagctcagacagtCtccagtggctcccgtgccat	11	14	2	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:201190709C>T	uc001gwc.2	+	8	2288	c.1516C>T	c.(1516-1518)CTC>TTC	p.L506F	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CTCAGACAGTCTCCAGTGGCT	0.632													T	201190709	T	T	201190709	3	4	105	1	0	0	0	0	1	0	0	0	7590	913	32	3	10106	3	IGFN1	1	201190709	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	3877151	201190709	48059912	9	7208											
TLR5	7100	broad.mit.edu	37	chr1	223285038	223285038	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatctggagatgaggtacccGtaggagaaagtagagaatat	13	4	1	4			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:223285038G>A	uc001hnv.1	-	4	1782	c.1336C>T	c.(1336-1338)CGG>TGG	p.R446W	TLR5_uc001hnw.1_Missense_Mutation_p.R446W	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	446	Extracellular (Potential).		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		TGAGGTACCCGTAGGAGAAAG	0.403													A	223285038	A	A	223285038	3	1	105	1	0	0	0	0	1	0	0	0	15951	1144	40	1	1244	1	TLR5	1	223285038	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	22094329	223285038	25965583	10	7209											
C1orf150	148823	broad.mit.edu	37	chr1	247712504	247712504	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgaaaagatgggaaattAtctcctgcgaaaactcaggt	10	7	2	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr1:247712504A>T	uc001idf.2	+	1	56	c.11A>T	c.(10-12)TAT>TTT	p.Y4F	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_RNA|C1orf150_uc001idb.3_RNA|C1orf150_uc009xgx.2_Intron	NM_145278	NP_660321	Q5JQS6	CA150_HUMAN	hypothetical protein LOC148823	4											0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0241)			ATGGGAAATTATCTCCTGCGA	0.473													T	247712504	T	T	247712504	3	4	105	1	0	0	0	0	1	0	0	0	2004	449	16	5	13	5	C1orf150	1	247712504	Missense_Mutation	SNP	A	TCGA-06-6697-01A-11D-1845-08	24427466	247712504	1538117	11	7210											
EPAS1	2034	broad.mit.edu	37	chr2	46609718	46609718	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccaggactacagcctgtcGtcagcccacaaggtgtcagg	11	13	2	0	rs4953362	byFrequency	TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr2:46609718G>A	uc002ruv.2	+	15	2930	c.2442G>A	c.(2440-2442)TCG>TCA	p.S814S	EPAS1_uc002ruw.2_Silent_p.S280S	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	814					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			ACAGCCTGTCGTCAGCCCACA	0.567													A	46609718	A	A	46609718	2	1	105	1	0	0	0	0	0	0	0	1	5150	1132	40	1		1	EPAS1	2	46609718	Silent	SNP	G	TCGA-06-6697-01A-11D-1845-08		46609718	196589655	12	7211											
DARS	1615	broad.mit.edu	37	chr2	136682064	136682074	+	Splice_Site	DEL	GATGTCTAGAA	-	-													ggaagactgcctgactagttGatgtctagaagacagtaata							TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr2:136682064_136682074delGATGTCTAGAA	uc002tux.1	-	8	749	c.565_splice	c.e8-1	p.T189_splice	DARS_uc010fnj.1_Splice_Site_p.T89_splice	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase						aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	CTGACTAGTTGATGTCTAGAAGACAGTAATA	0.374													-	136682074	-	-	136682064	8	5	105	1	0	1	0	1	0	0	1	0	4241	1294	45	0	972	0	DARS	2	136682064	Splice_Site	DEL	GATGTCTAGAA	TCGA-06-6697-01A-11D-1845-08	90072346	136682064	106517309	13	7212											
THSD7B	80731	broad.mit.edu	37	chr2	138373761	138373761	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atagtcatgcgatccccacaCaatgcagagaagaactcgcc	8	13	1	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr2:138373761C>T	uc002tva.1	+	17	3353	c.3353C>T	c.(3352-3354)ACA>ATA	p.T1118I	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GATCCCCACACAATGCAGAGA	0.418													T	138373761	T	T	138373761	3	4	105	1	0	0	0	0	1	0	0	0	15877	478	17	3	3418	3	THSD7B	2	138373761	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	1691697	138373761	104825612	14	7213											
FAP	2191	broad.mit.edu	37	chr2	163074520	163074520	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gggtatggaatatttattgtTctaggatattgttcatcgcc	10	5	2	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr2:163074520T>A	uc002ucd.2	-	9	946	c.738A>T	c.(736-738)AGA>AGT	p.R246S	FAP_uc010zct.1_Missense_Mutation_p.R221S|FAP_uc010fpd.2_Intron|FAP_uc010fpe.1_Missense_Mutation_p.R213S	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	246	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						TATTTATTGTTCTAGGATATT	0.353													A	163074520	A	A	163074520	3	1	105	1	0	0	0	0	1	0	0	0	5673	1780	62	5	1616	5	FAP	2	163074520	Missense_Mutation	SNP	T	TCGA-06-6697-01A-11D-1845-08	24700759	163074520	80124853	15	7214											
DHRS9	10170	broad.mit.edu	37	chr2	169939876	169939876	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aataatgctggtgttcccggCgtgctggctcccactgactg	12	12	0	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr2:169939876C>T	uc002uep.2	+	6	1855	c.351C>T	c.(349-351)GGC>GGT	p.G117G	DHRS9_uc002ueq.2_Silent_p.G117G|DHRS9_uc010zdc.1_Silent_p.G177G|DHRS9_uc010zdd.1_Silent_p.G117G|DHRS9_uc010zde.1_Silent_p.G117G	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	117					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						GTGTTCCCGGCGTGCTGGCTC	0.468													T	169939876	T	T	169939876	2	4	105	1	0	0	0	0	0	0	0	1	4498	755	27	1		1	DHRS9	2	169939876	Silent	SNP	C	TCGA-06-6697-01A-11D-1845-08	6865356	169939876	73259497	16	7215											
TTN	7273	broad.mit.edu	37	chr2	179599471	179599471	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtactgcagctatcactgccGacgtcattcactgcttcaca	7	14	4	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr2:179599471G>A	uc010zfg.1	-	48	11672	c.11448C>T	c.(11446-11448)GTC>GTT	p.V3816V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.V477V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4743							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCACTGCCGACGTCATTCA	0.363													A	179599471	A	A	179599471	2	1	105	1	0	0	0	0	0	0	0	1	16732	1045	37	2		2	TTN	2	179599471	Silent	SNP	G	TCGA-06-6697-01A-11D-1845-08	9659595	179599471	63599902	17	7216											
DGKD	8527	broad.mit.edu	37	chr2	234363420	234363420	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cctttgcagagagtattacaCggagaaatgtgtcatgaaca	10	7	1	3			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr2:234363420C>G	uc002vui.1	+	19	2288	c.2276C>G	c.(2275-2277)ACG>AGG	p.T759R	DGKD_uc002vuj.1_Missense_Mutation_p.T715R|DGKD_uc010fyh.1_Missense_Mutation_p.T626R|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	759					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GAGTATTACACGGAGAAATGT	0.453													G	234363420	G	G	234363420	3	3	105	1	0	0	0	0	1	0	0	0	4467	536	19	5	2374	5	DGKD	2	234363420	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	54763949	234363420	8835953	18	7217											
KCNH8	131096	broad.mit.edu	37	chr3	19574969	19574969	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggaaaacgttctgtcacCtcagcagccatcacggtttt	8	12	5	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr3:19574969C>T	uc003cbk.1	+	16	2897	c.2702C>T	c.(2701-2703)CCT>CTT	p.P901L	KCNH8_uc010hex.1_Missense_Mutation_p.P362L	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	901	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						GTTCTGTCACCTCAGCAGCCA	0.493													T	19574969	T	T	19574969	3	4	105	1	0	0	0	0	1	0	0	0	8038	681	24	3	2764	3	KCNH8	3	19574969	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08		19574969	178447461	19	7218											
NBEAL2	23218	broad.mit.edu	37	chr3	47041686	47041686	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cctggaacggtctagtgtagGatcaggcaacactgctggtg	14	9	2	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr3:47041686G>T	uc003cqp.2	+	27	4276	c.4097G>T	c.(4096-4098)GGA>GTA	p.G1366V	NBEAL2_uc010hjm.1_Missense_Mutation_p.G743V|NBEAL2_uc010hjn.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1366							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TCTAGTGTAGGATCAGGCAAC	0.637													T	47041686	T	T	47041686	3	4	105	1	0	0	0	0	1	0	0	0	10189	1174	41	5	4203	5	NBEAL2	3	47041686	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	27466717	47041686	150980744	20	7219											
CELSR3	1951	broad.mit.edu	37	chr3	48685382	48685382	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggtagcgagggtagcgacGggccccccggggagaactgg	19	10	0	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr3:48685382G>A	uc003cul.2	-	20	7302	c.7021C>T	c.(7021-7023)CGT>TGT	p.R2341C	CELSR3_uc003cuf.1_Missense_Mutation_p.R2411C|CELSR3_uc010hkg.2_Missense_Mutation_p.R324C	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2341	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGGTAGCGACGGGCCCCCCGG	0.632													A	48685382	A	A	48685382	3	1	105	1	0	0	0	0	1	0	0	0	3223	1116	39	2	2981	2	CELSR3	3	48685382	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	1643696	48685382	149337048	21	7220											
DNAJC13	23317	broad.mit.edu	37	chr3	132217972	132217972	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaccattggttatttcagatTtacagccttataaatatgca	5	7	1	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr3:132217972T>A	uc003eor.2	+	37	4224	c.4159T>A	c.(4159-4161)TTA>ATA	p.L1387I		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1387							heat shock protein binding			ovary(1)|breast(1)	2						TATTTCAGATTTACAGCCTTA	0.328													A	132217972	A	A	132217972	3	1	105	1	0	0	0	0	1	0	0	0	4632	1838	64	5	4301	5	DNAJC13	3	132217972	Missense_Mutation	SNP	T	TCGA-06-6697-01A-11D-1845-08	83532590	132217972	65804458	22	7221											
ACAD11	84129	broad.mit.edu	37	chr3	132361623	132361623	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ccaattgaaaacaaggctttCtggactttaaattctctatc	5	9	2	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr3:132361623C>A	uc003eov.3	-	3	653	c.273G>T	c.(271-273)CAG>CAT	p.Q91H	ACAD11_uc003eoy.2_Missense_Mutation_p.Q91H	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	91						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						ACAAGGCTTTCTGGACTTTAA	0.323													A	132361623	A	A	132361623	3	1	105	1	0	0	0	0	1	0	0	0	109	912	32	5	2141	5	ACAD11	3	132361623	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	143651	132361623	65660807	23	7222											
ATP11B	23200	broad.mit.edu	37	chr3	182559871	182559871	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	attttttgatagattcatggGacgaatgatcataacccaac	7	7	2	3			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr3:182559871G>T	uc003flb.2	+	8	922	c.665G>T	c.(664-666)GGA>GTA	p.G222V		NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	222	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			AGATTCATGGGACGAATGATC	0.294													T	182559871	T	T	182559871	3	4	105	1	0	0	0	0	1	0	0	0	1120	1174	41	5	695	5	ATP11B	3	182559871	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	50198248	182559871	15462559	24	7223											
DNAH5	1767	broad.mit.edu	37	chr5	13717485	13717485	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacagtggcattaaagtccGcttggttaaattcgtagggg	13	7	0	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr5:13717485G>A	uc003jfd.2	-	73	12686	c.12644C>T	c.(12643-12645)GCG>GTG	p.A4215V	DNAH5_uc003jfc.2_Missense_Mutation_p.A383V	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4215	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATTAAAGTCCGCTTGGTTAAA	0.532									Kartagener_syndrome				A	13717485	A	A	13717485	3	1	105	1	0	0	0	0	1	0	0	0	4604	1087	38	1	1258	1	DNAH5	5	13717485	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		13717485	167197775	25	7224											
C5orf42	65250	broad.mit.edu	37	chr5	37183582	37183582	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgtcagcatccctggaataAggtaggtctctttcaagaat	9	8	3	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr5:37183582A>C	uc011cpa.1	-	26	4932	c.4701T>G	c.(4699-4701)CCT>CCG	p.P1567P	C5orf42_uc011coy.1_Silent_p.P68P|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Silent_p.P642P|C5orf42_uc011cpb.1_Silent_p.P448P	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1567										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CCCTGGAATAAGGTAGGTCTC	0.323													C	37183582	C	C	37183582	2	2	105	1	0	0	0	0	0	0	0	1	2301	59	3	5		5	C5orf42	5	37183582	Silent	SNP	A	TCGA-06-6697-01A-11D-1845-08	23466097	37183582	143731678	26	7225											
IRF1	3659	broad.mit.edu	37	chr5	131821402	131821402	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccttcctcatcctcatctGttgtagctgtggatggggaa	10	11	3	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr5:131821402G>A	uc003kxa.2	-	8	908	c.674C>T	c.(673-675)ACA>ATA	p.T225I	C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.T225I|IRF1_uc010jdt.1_Missense_Mutation_p.T225I	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	225					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		ATCCTCATCTGTTGTAGCTGT	0.542													A	131821402	A	A	131821402	3	1	105	1	0	0	0	0	1	0	0	0	7827	1377	48	3	315	3	IRF1	5	131821402	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	94637820	131821402	49093858	27	7226											
DSP	1832	broad.mit.edu	37	chr6	7576571	7576571	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagcaattgaggaattatcGtgataactatcaggctttct	8	7	2	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr6:7576571G>A	uc003mxp.1	+	19	2954	c.2675G>A	c.(2674-2676)CGT>CAT	p.R892H	DSP_uc003mxq.1_Missense_Mutation_p.R892H	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	892	Globular 1.|Spectrin 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGAATTATCGTGATAACTAT	0.368													A	7576571	A	A	7576571	3	1	105	1	0	0	0	0	1	0	0	0	4781	1145	40	1	2749	1	DSP	6	7576571	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		7576571	163538496	28	7227											
OR10C1	442194	broad.mit.edu	37	chr6	29408603	29408603	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gctacgatccggccactgacCctctggtgtccctcttctat	8	16	3	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr6:29408603C>A	uc011dlp.1	+	1	811	c.811C>A	c.(811-813)CCT>ACT	p.P271T	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	271	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCCACTGACCCTCTGGTGTC	0.552													A	29408603	A	A	29408603	3	1	105	1	0	0	0	0	1	0	0	0	10898	623	22	5	813	5	OR10C1	6	29408603	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	21832032	29408603	141706464	29	7228											
ZNF318	24149	broad.mit.edu	37	chr6	43308071	43308072	+	Frame_Shift_Del	DEL	TC	-	-													ccttgtcatcctcctttactTctttcacagcctttgccttt							TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr6:43308071_43308072delTC	uc003oux.2	-	10	3742_3743	c.3664_3665delGA	c.(3664-3666)GAAfs	p.E1222fs	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1222	Lys-rich.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTCCTTTACTTCTTTCACAGCC	0.45													-	43308072	-	-	43308071	7	5	105	1	0	1	0	1	0	0	0	0	17833	1783	62	0	3178	0	ZNF318	6	43308071	Frame_Shift_Del	DEL	TC	TCGA-06-6697-01A-11D-1845-08	13899468	43308071	127806996	30	7229											
FILIP1	27145	broad.mit.edu	37	chr6	76023523	76023523	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tctagttgttgagagaggaaGttagccttatcctgctcagt	11	7	2	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr6:76023523G>C	uc003pia.2	-	5	2398	c.2025C>G	c.(2023-2025)AAC>AAG	p.N675K	FILIP1_uc003phy.1_Missense_Mutation_p.N675K|FILIP1_uc003phz.2_Missense_Mutation_p.N576K|FILIP1_uc010kbe.2_Missense_Mutation_p.N678K|FILIP1_uc003pib.1_Missense_Mutation_p.N427K	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	675	Potential.									skin(3)|ovary(1)	4						GAGAGAGGAAGTTAGCCTTAT	0.438													C	76023523	C	C	76023523	3	2	105	1	0	0	0	0	1	0	0	0	5894	1020	36	5	1624	5	FILIP1	6	76023523	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	32715452	76023523	95091544	31	7230											
SDK1	221935	broad.mit.edu	37	chr7	4050626	4050626	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaaggtgcatctgtcaaaCgttggccctgagatgacagg	14	8	2	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr7:4050626C>T	uc003smx.2	+	15	2299	c.2160C>T	c.(2158-2160)AAC>AAT	p.N720N	SDK1_uc010kso.2_Translation_Start_Site	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	720	Fibronectin type-III 1.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ATCTGTCAAACGTTGGCCCTG	0.498													T	4050626	T	T	4050626	2	4	105	1	0	0	0	0	0	0	0	1	13968	535	19	1		1	SDK1	7	4050626	Silent	SNP	C	TCGA-06-6697-01A-11D-1845-08		4050626	155088037	32	7231											
PCLO	27445	broad.mit.edu	37	chr7	82579889	82579889	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttccagagcagcatactgacCttccaaaattgcctgctctg	7	13	1	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr7:82579889C>A	uc003uhx.2	-	6	10304	c.10015G>T	c.(10015-10017)GGT>TGT	p.G3339C	PCLO_uc003uhv.2_Missense_Mutation_p.G3339C|PCLO_uc010lec.2_Missense_Mutation_p.G304C	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3270					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCATACTGACCTTCCAAAATT	0.478													A	82579889	A	A	82579889	3	1	105	1	0	0	0	0	1	0	0	0	11583	681	24	5	5510	5	PCLO	7	82579889	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	78529263	82579889	76558774	33	7232											
PCLO	27445	broad.mit.edu	37	chr7	82784328	82784328	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagggctttgctgggctaggCtgttgagctgagggttttgc	18	6	0	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr7:82784328C>T	uc003uhx.2	-	2	1918	c.1629G>A	c.(1627-1629)CAG>CAA	p.Q543Q	PCLO_uc003uhv.2_Silent_p.Q543Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	489	Gln-rich.|Pro-rich.|10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGGGCTAGGCTGTTGAGCTG	0.547													T	82784328	T	T	82784328	2	4	105	1	0	0	0	0	0	0	0	1	11583	796	28	3		3	PCLO	7	82784328	Silent	SNP	C	TCGA-06-6697-01A-11D-1845-08	204439	82784328	76354335	34	7233											
ABCB4	5244	broad.mit.edu	37	chr7	87049323	87049323	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacactcctacctgtcttagCattgctttaaaagccattga	5	12	1	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr7:87049323C>T	uc003uiv.1	-	19	2461	c.2385G>A	c.(2383-2385)ATG>ATA	p.M795I	ABCB4_uc003uiw.1_Missense_Mutation_p.M795I|ABCB4_uc003uix.1_Missense_Mutation_p.M795I	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	795	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CCTGTCTTAGCATTGCTTTAA	0.428													T	87049323	T	T	87049323	3	4	105	1	0	0	0	0	1	0	0	0	43	710	25	3	1515	3	ABCB4	7	87049323	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	4264995	87049323	72089340	35	7234											
PIK3CG	5294	broad.mit.edu	37	chr7	106523501	106523501	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatcgagattgtgaaagacGccacgacaattgccaaaatt	9	8	0	4			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr7:106523501G>A	uc003vdv.3	+	8	2738	c.2653G>A	c.(2653-2655)GCC>ACC	p.A885T	PIK3CG_uc003vdu.2_Missense_Mutation_p.A885T|PIK3CG_uc003vdw.2_Missense_Mutation_p.A885T	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	885	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TGTGAAAGACGCCACGACAAT	0.478													A	106523501	A	A	106523501	3	1	105	1	0	0	0	0	1	0	0	0	11916	1087	38	1	2679	1	PIK3CG	7	106523501	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	19474178	106523501	52615162	36	7235											
ZNF282	8427	broad.mit.edu	37	chr7	148909483	148909483	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcccaggacctcttgtcccGgattaaacaggaggagcatc	11	12	1	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr7:148909483G>A	uc003wfm.2	+	6	1091	c.986G>A	c.(985-987)CGG>CAG	p.R329Q	ZNF282_uc011kun.1_Missense_Mutation_p.R329Q|ZNF282_uc003wfn.2_Missense_Mutation_p.R269Q|ZNF282_uc003wfo.2_Intron	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	329					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CTCTTGTCCCGGATTAAACAG	0.463													A	148909483	A	A	148909483	3	1	105	1	0	0	0	0	1	0	0	0	17816	1116	39	2	1008	2	ZNF282	7	148909483	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	42385982	148909483	10229180	37	7236											
NCOA2	10499	broad.mit.edu	37	chr8	71057069	71057069	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgcccagttgccctggtcGtgggttattaaaagctaagg	12	10	0	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr8:71057069G>A	uc003xyn.1	-	13	2782	c.2620C>T	c.(2620-2622)CGA>TGA	p.R874*	NCOA2_uc011lfb.1_Intron	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	874					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TGCCCTGGTCGTGGGTTATTA	0.388			T	RUNXBP2	AML								A	71057069	A	A	71057069	4	1	105	1	0	0	0	0	0	1	0	0	10229	1153	40	1	1818	1	NCOA2	8	71057069	Nonsense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		71057069	75306953	38	7237											
PHF20L1	51105	broad.mit.edu	37	chr8	133806658	133806658	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcattttgatttttgaggtAtccatcacgaattgaaaaaa	7	5	1	3			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr8:133806658A>G	uc003ytt.2	+	3	411	c.86A>G	c.(85-87)TAT>TGT	p.Y29C	PHF20L1_uc003ytr.2_Missense_Mutation_p.Y29C|PHF20L1_uc010mdv.2_Missense_Mutation_p.Y29C|PHF20L1_uc003yts.2_Missense_Mutation_p.Y29C|PHF20L1_uc011lja.1_Missense_Mutation_p.Y29C|PHF20L1_uc003ytu.1_RNA|PHF20L1_uc003ytq.2_Missense_Mutation_p.Y29C	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	29	Tudor 1.						nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TTTTTGAGGTATCCATCACGA	0.338													G	133806658	G	G	133806658	3	3	105	1	0	0	0	0	1	0	0	0	11832	449	16	4	92	4	PHF20L1	8	133806658	Missense_Mutation	SNP	A	TCGA-06-6697-01A-11D-1845-08	62749589	133806658	12557364	39	7238											
SECISBP2	79048	broad.mit.edu	37	chr9	91973081	91973081	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gaagatggccccccagccctGaaagaaaaagaagagccaca	10	12	0	5			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr9:91973081G>A	uc004aqj.1	+	16	2516	c.2436G>A	c.(2434-2436)CTG>CTA	p.L812L	SECISBP2_uc011ltk.1_Silent_p.L811L|SECISBP2_uc004aqk.1_Silent_p.L739L|SECISBP2_uc010mqo.1_Silent_p.L517L|SECISBP2_uc011ltl.1_Silent_p.L744L	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	812					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						CCCCAGCCCTGAAAGAAAAAG	0.562													A	91973081	A	A	91973081	2	1	105	1	0	0	0	0	0	0	0	1	14006	1277	45	3		3	SECISBP2	9	91973081	Silent	SNP	G	TCGA-06-6697-01A-11D-1845-08		91973081	49240350	40	7239											
LAMC3	10319	broad.mit.edu	37	chr9	133927934	133927934	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcccctcatactgaccttcCgggtgccccccggggactcc	10	19	1	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr9:133927934C>T	uc004caa.1	+	10	1785	c.1687C>T	c.(1687-1689)CGG>TGG	p.R563W		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	563	Laminin IV type A.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		ACTGACCTTCCGGGTGCCCCC	0.597											OREG0019556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	133927934	T	T	133927934	3	4	105	1	0	0	0	0	1	0	0	0	8616	643	23	2	1725	2	LAMC3	9	133927934	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	41954853	133927934	7285497	41	7240											
CDH23	64072	broad.mit.edu	37	chr10	73567464	73567464	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacactgcaggaggtgcgcGttgtgctagaggacatcaac	13	10	2	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr10:73567464G>A	uc001jrx.3	+	57	8877	c.8500G>A	c.(8500-8502)GTT>ATT	p.V2834I	CDH23_uc001jsg.3_Missense_Mutation_p.V594I|CDH23_uc001jsh.3_Missense_Mutation_p.V594I|CDH23_uc001jsi.3_Missense_Mutation_p.V594I	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2834	Cadherin 26.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GGAGGTGCGCGTTGTGCTAGA	0.632													A	73567464	A	A	73567464	3	1	105	1	0	0	0	0	1	0	0	0	3108	1145	40	1	9075	1	CDH23	10	73567464	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		73567464	61967283	42	7241											
MYOF	26509	broad.mit.edu	37	chr10	95119651	95119651	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttttcggaccagccttcgcCgtctatgagtgtggtacatt	11	10	1	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr10:95119651C>T	uc001kin.2	-	29	3182	c.3059G>A	c.(3058-3060)CGG>CAG	p.R1020Q	MYOF_uc001kio.2_Missense_Mutation_p.R1007Q|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1020	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						CAGCCTTCGCCGTCTATGAGT	0.502													T	95119651	T	T	95119651	3	4	105	1	0	0	0	0	1	0	0	0	10089	652	23	2	3230	2	MYOF	10	95119651	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	21552187	95119651	40415096	43	7242											
OR51V1	283111	broad.mit.edu	37	chr11	5221570	5221570	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catagtgaggaggacagaggActccatgaaggacagaccat	13	8	0	4			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr11:5221570A>T	uc010qyz.1	-	1	361	c.361T>A	c.(361-363)TCC>ACC	p.S121T		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	121	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGACAGAGGACTCCATGAAG	0.473													T	5221570	T	T	5221570	3	4	105	1	0	0	0	0	1	0	0	0	11107	275	10	5	607	5	OR51V1	11	5221570	Missense_Mutation	SNP	A	TCGA-06-6697-01A-11D-1845-08		5221570	129784946	44	7243											
OR10A3	26496	broad.mit.edu	37	chr11	7960995	7960995	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaaccccaaagagctgcaCctggagctcaggaaagttag	11	10	1	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr11:7960995C>T	uc010rbi.1	-	1	73	c.73G>A	c.(73-75)GTG>ATG	p.V25M		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAGAGCTGCACCTGGAGCTCA	0.413													T	7960995	T	T	7960995	3	4	105	1	0	0	0	0	1	0	0	0	10891	507	18	3	874	3	OR10A3	11	7960995	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	2739425	7960995	127045521	45	7244											
INSC	387755	broad.mit.edu	37	chr11	15198673	15198673	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acagattgagaagctgctaaTggagaaatgctcggagctct	12	7	1	3			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr11:15198673T>C	uc001mly.2	+	4	606	c.560T>C	c.(559-561)ATG>ACG	p.M187T	INSC_uc001mlz.2_Missense_Mutation_p.M140T|INSC_uc001mma.2_Missense_Mutation_p.M140T|INSC_uc010rcs.1_Missense_Mutation_p.M140T|INSC_uc001mmb.2_Missense_Mutation_p.M140T|INSC_uc001mmc.2_Missense_Mutation_p.M140T	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	187					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						AAGCTGCTAATGGAGAAATGC	0.353													C	15198673	C	C	15198673	3	2	105	1	0	0	0	0	1	0	0	0	7764	1464	51	4	574	4	INSC	11	15198673	Missense_Mutation	SNP	T	TCGA-06-6697-01A-11D-1845-08	7237678	15198673	119807843	46	7245											
OR1S1	219959	broad.mit.edu	37	chr11	57982888	57982888	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcagttatcatcttccccttTacactcagcttcttttccta	2	14	5	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr11:57982888T>C	uc010rkc.1	+	1	672	c.672T>C	c.(670-672)TTT>TTC	p.F224F		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	224	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				TCTTCCCCTTTACACTCAGCT	0.453													C	57982888	C	C	57982888	2	2	105	1	0	0	0	0	0	0	0	1	10972	1751	61	4		4	OR1S1	11	57982888	Silent	SNP	T	TCGA-06-6697-01A-11D-1845-08	42784215	57982888	77023628	47	7246											
MMP27	64066	broad.mit.edu	37	chr11	102575419	102575419	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaaaaatgcttgcatttcccGaattttgtcatctatgagac	6	8	2	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr11:102575419G>A	uc001phd.1	-	2	213	c.190C>T	c.(190-192)CGG>TGG	p.R64W		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	64					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		TGCATTTCCCGAATTTTGTCA	0.428													A	102575419	A	A	102575419	3	1	105	1	0	0	0	0	1	0	0	0	9664	1057	37	2	1387	2	MMP27	11	102575419	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	44592531	102575419	32431097	48	7247											
KDELC2	143888	broad.mit.edu	37	chr11	108345675	108345675	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgctggactggcgctcggcaTatttctgaaacgtgggttta	13	8	1	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr11:108345675T>A	uc001pkj.2	-	8	1469	c.1403A>T	c.(1402-1404)TAT>TTT	p.Y468F	KDELC2_uc001pki.2_Missense_Mutation_p.Y412F	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	468						endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		GCGCTCGGCATATTTCTGAAA	0.507													A	108345675	A	A	108345675	3	1	105	1	0	0	0	0	1	0	0	0	8118	1406	49	5	124	5	KDELC2	11	108345675	Missense_Mutation	SNP	T	TCGA-06-6697-01A-11D-1845-08	5770256	108345675	26660841	49	7248											
CLEC7A	64581	broad.mit.edu	37	chr12	10277922	10277922	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atttgagctgtctatctttaGgagattagagcccagttgcc	10	8	2	3			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr12:10277922G>C	uc001qxg.2	-	4	653	c.466C>G	c.(466-468)CTA>GTA	p.L156V	CLEC7A_uc001qxe.3_RNA|CLEC7A_uc001qxf.2_Missense_Mutation_p.L110V|CLEC7A_uc001qxh.2_Missense_Mutation_p.L110V|CLEC7A_uc001qxi.2_Missense_Mutation_p.L156V|CLEC7A_uc001qxj.2_Missense_Mutation_p.L77V|CLEC7A_uc009zhg.1_Intron|CLEC7A_uc001qxk.1_RNA|CLEC7A_uc001qxl.1_Missense_Mutation_p.L156V|CLEC7A_uc010sgy.1_Missense_Mutation_p.L110V|CLEC7A_uc001qxm.1_Missense_Mutation_p.L110V	NM_197947	NP_922938	Q9BXN2	CLC7A_HUMAN	dendritic cell-associated C-type lectin 1	156	C-type lectin.|Extracellular (Potential).				carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding			central_nervous_system(1)	1						TCTATCTTTAGGAGATTAGAG	0.383													C	10277922	C	C	10277922	3	2	105	1	0	0	0	0	1	0	0	0	3521	991	35	5	289	5	CLEC7A	12	10277922	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		10277922	123573973	50	7249											
KLRC3	3823	broad.mit.edu	37	chr12	10587963	10587963	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gccatcaggacaatgcaaatGattcctaggacctcggcagt	10	11	1	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr12:10587963G>T	uc001qyh.2	-	2	241	c.234C>A	c.(232-234)ATC>ATA	p.I78I	KLRC2_uc010she.1_Silent_p.I78I|KLRC2_uc001qyk.2_Silent_p.I78I	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	78	Helical; Signal-anchor for type II membrane protein; (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						CAATGCAAATGATTCCTAGGA	0.428													T	10587963	T	T	10587963	2	4	105	1	0	0	0	0	0	0	0	1	8417	1280	45	5		5	KLRC3	12	10587963	Silent	SNP	G	TCGA-06-6697-01A-11D-1845-08	310041	10587963	123263932	51	7250											
HDAC7	51564	broad.mit.edu	37	chr12	48181754	48181754	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcccaggatcacacagctcGtcatgacagaggcagagtaa	11	11	2	3			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr12:48181754G>A	uc010slp.1	-	1	194	c.-74C>T	c.(-76--72)GACGA>GATGA		HDAC7_uc009zku.2_Intron|HDAC7_uc001rqe.2_Intron|HDAC7_uc010slo.1_Intron|HDAC7_uc001rqj.3_Intron|HDAC7_uc001rqk.3_Intron			Q8WUI4	HDAC7_HUMAN	Synthetic construct DNA, clone: pF1KB0470, Homo sapiens HDAC7 gene for histone deacetylase 7, without stop codon, in Flexi system.						negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		cacacagctcgtcatgacaga	0.274													A	48181754	A	A	48181754	1	1	105	1	0	0	0	0	0	0	0	0	7012	1160	40	1		1	HDAC7	12	48181754	Translation_Start_Site	SNP	G	TCGA-06-6697-01A-11D-1845-08	37593791	48181754	85670141	52	7251											
METTL1	4234	broad.mit.edu	37	chr12	58162873	58162873	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaattcttccctccattaCgtagaactttcttcccctcc	4	15	2	1	rs140194153	byFrequency	TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr12:58162873C>T	uc010ssd.1	-	6	785	c.737G>A	c.(736-738)CGT>CAT	p.R246H	CYP27B1_uc001spz.1_5'Flank|CYP27B1_uc001sqa.1_5'Flank|METTL1_uc009zqc.2_3'UTR	NM_005371	NP_005362	Q9UBP6	TRMB_HUMAN	methyltransferase-like protein 1 isoform a	246						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding				0	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			CCCTCCATTACGTAGAACTTT	0.532													T	58162873	T	T	58162873	3	4	105	1	0	0	0	0	1	0	0	0	9493	536	19	1	97	1	METTL1	12	58162873	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	9981119	58162873	75689022	53	7252											
LRRIQ1	84125	broad.mit.edu	37	chr12	85459186	85459186	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaacttaagtacattgaTgcacaggtatgctctctgcc	7	9	1	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr12:85459186T>C	uc001tac.2	+	9	2649	c.2538T>C	c.(2536-2538)GAT>GAC	p.D846D	LRRIQ1_uc001tab.1_Silent_p.D846D	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	846	LRR 2.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		AGTACATTGATGCACAGGTAT	0.333													C	85459186	C	C	85459186	2	2	105	1	0	0	0	0	0	0	0	1	9029	1461	51	4		4	LRRIQ1	12	85459186	Silent	SNP	T	TCGA-06-6697-01A-11D-1845-08	27296313	85459186	48392709	54	7253											
KIAA1033	23325	broad.mit.edu	37	chr12	105519878	105519878	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgcacatagtattcggtcaAtttttgcaaatgtagaagcc	8	7	1	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr12:105519878A>G	uc001tld.2	+	11	970	c.883A>G	c.(883-885)ATT>GTT	p.I295V	KIAA1033_uc010swr.1_Missense_Mutation_p.I295V|KIAA1033_uc010sws.1_Missense_Mutation_p.I107V	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	295					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						TATTCGGTCAATTTTTGCAAA	0.308													G	105519878	G	G	105519878	3	3	105	1	0	0	0	0	1	0	0	0	8206	101	4	4	925	4	KIAA1033	12	105519878	Missense_Mutation	SNP	A	TCGA-06-6697-01A-11D-1845-08	20060692	105519878	28332017	55	7254											
DYNC1H1	1778	broad.mit.edu	37	chr14	102514280	102514280	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggcgccctgcctggatgcGgacactgcacaccaccgcgt	13	17	0	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr14:102514280G>A	uc001yks.2	+	73	13297	c.13133G>A	c.(13132-13134)CGG>CAG	p.R4378Q		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4378					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GCCTGGATGCGGACACTGCAC	0.612													A	102514280	A	A	102514280	3	1	105	1	0	0	0	0	1	0	0	0	4841	1116	39	2	13423	2	DYNC1H1	14	102514280	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		102514280	4835260	56	7255											
NRG4	145957	broad.mit.edu	37	chr15	76301577	76301577	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaatagtaggtatcacataaCaaagccccccattcaggcaa	7	11	2	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr15:76301577C>A	uc002bbo.2	-	3	252	c.68G>T	c.(67-69)TGT>TTT	p.C23F	NRG4_uc010bkm.1_RNA|NRG4_uc002bbn.2_RNA|NRG4_uc010bkn.2_RNA|NRG4_uc010bko.2_RNA|NRG4_uc002bbp.2_RNA	NM_138573	NP_612640	Q8WWG1	NRG4_HUMAN	neuregulin 4	23	Extracellular (Potential).|EGF-like.					extracellular region|integral to membrane|plasma membrane	growth factor activity				0						TATCACATAACAAAGCCCCCC	0.388													A	76301577	A	A	76301577	3	1	105	1	0	0	0	0	1	0	0	0	10650	478	17	5	295	5	NRG4	15	76301577	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08		76301577	26229815	57	7256											
SRRM2	23524	broad.mit.edu	37	chr16	2812703	2812703	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaaagaagaggcagatctgGctcatcttcagagcggaaaa	11	8	5	4			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr16:2812703G>A	uc002crk.2	+	11	2723	c.2174G>A	c.(2173-2175)GGC>GAC	p.G725D	SRRM2_uc002crj.1_Missense_Mutation_p.G629D|SRRM2_uc002crl.1_Missense_Mutation_p.G725D|SRRM2_uc010bsu.1_Missense_Mutation_p.G629D	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	725	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GGCAGATCTGGCTCATCTTCA	0.463													A	2812703	A	A	2812703	3	1	105	1	0	0	0	0	1	0	0	0	15168	1203	42	3	2212	3	SRRM2	16	2812703	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		2812703	87542050	58	7257											
CHD9	80205	broad.mit.edu	37	chr16	53276816	53276816	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cacttttgaaatgattcttgGaggctgtggagagcttaatg	12	5	1	3			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr16:53276816G>T	uc002ehb.2	+	12	3106	c.2942G>T	c.(2941-2943)GGA>GTA	p.G981V	CHD9_uc002egy.2_Missense_Mutation_p.G981V|CHD9_uc002eha.1_Missense_Mutation_p.G981V|CHD9_uc002ehc.2_Missense_Mutation_p.G981V|CHD9_uc002ehf.2_Missense_Mutation_p.G95V|CHD9_uc002ehd.2_Missense_Mutation_p.G507V|CHD9_uc002ehe.1_Missense_Mutation_p.G95V	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	981	Helicase ATP-binding.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ATGATTCTTGGAGGCTGTGGA	0.363													T	53276816	T	T	53276816	3	4	105	1	0	0	0	0	1	0	0	0	3332	1174	41	5	2988	5	CHD9	16	53276816	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	50464113	53276816	37077937	59	7258											
CDYL2	124359	broad.mit.edu	37	chr16	80718602	80718602	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatcccgttctgagactttTtcaggggcattatttgcaaa	8	10	2	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr16:80718602T>C	uc002ffs.2	-	2	554	c.449A>G	c.(448-450)AAA>AGA	p.K150R		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	150						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						CTGAGACTTTTTCAGGGGCAT	0.512													C	80718602	C	C	80718602	3	2	105	1	0	0	0	0	1	0	0	0	3186	1841	64	4	1095	4	CDYL2	16	80718602	Missense_Mutation	SNP	T	TCGA-06-6697-01A-11D-1845-08	27441786	80718602	9636151	60	7259											
MAP2K3	5606	broad.mit.edu	37	chr17	21205510	21205510	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccttggacaagttctaccGgaaggtgctggataaaaaca	10	8	1	0	rs148304866		TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr17:21205510G>A	uc002gys.2	+	6	720	c.455G>A	c.(454-456)CGG>CAG	p.R152Q	MAP2K3_uc002gyt.2_Missense_Mutation_p.R123Q|MAP2K3_uc002gyu.2_Missense_Mutation_p.R123Q	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	152	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		AAGTTCTACCGGAAGGTGCTG	0.592													A	21205510	A	A	21205510	3	1	105	1	0	0	0	0	1	0	0	0	9238	1116	39	2	477	2	MAP2K3	17	21205510	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		21205510	59989700	61	7260											
NOS2	4843	broad.mit.edu	37	chr17	26094858	26094858	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggacatcaaacgtctcacaGgctgcctggaagaaggtgga	13	10	2	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr17:26094858G>A	uc002gzu.2	-	18	2304	c.2040C>T	c.(2038-2040)GCC>GCT	p.A680A	NOS2_uc010wab.1_Silent_p.A645A	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	680					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	ACGTCTCACAGGCTGCCTGGA	0.473													A	26094858	A	A	26094858	2	1	105	1	0	0	0	0	0	0	0	1	10543	987	35	3		3	NOS2	17	26094858	Silent	SNP	G	TCGA-06-6697-01A-11D-1845-08	4889348	26094858	55100352	62	7261											
EVI2B	2124	broad.mit.edu	37	chr17	29632208	29632208	+	Missense_Mutation	SNP	C	A	A													gtaaaagtatagacaaatgaCtttggtggttgtgtggtaga							TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr17:29632208C>A	uc002hgk.2	-	2	575	c.420G>T	c.(418-420)AAG>AAT	p.K140N	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.K155N	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	140	Extracellular (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		AGACAAATGACTTTGGTGGTT	0.438													A	29632208	A	A	29632208	3	1	105	1	0	0	0	0	1	0	0	0	5288	564	20	5	930	5	EVI2B	17	29632208	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	3537350	29632208	51563002	63	7262	9	2									
EVI2B	2124	broad.mit.edu	37	chr17	29632210	29632210	+	Missense_Mutation	SNP	T	G	G													aaaagtatagacaaatgactTtggtggttgtgtggtagaag							TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr17:29632210T>G	uc002hgk.2	-	2	573	c.418A>C	c.(418-420)AAG>CAG	p.K140Q	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.K155Q	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	140	Extracellular (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		ACAAATGACTTTGGTGGTTGT	0.438													G	29632210	G	G	29632210	3	3	105	1	0	0	0	0	1	0	0	0	5288	1850	64	5	932	5	EVI2B	17	29632210	Missense_Mutation	SNP	T	TCGA-06-6697-01A-11D-1845-08	2	29632210	51563000	64	7263	9	2									
PEX12	5193	broad.mit.edu	37	chr17	33904178	33904178	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cagcagtggtgagtgatgctGagcttttcctaggatgtatc	13	7	0	3			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr17:33904178G>A	uc002hjp.2	-	2	1175	c.559C>T	c.(559-561)CAG>TAG	p.Q187*		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	187	Peroxisomal matrix (Potential).				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GAGTGATGCTGAGCTTTTCCT	0.493													A	33904178	A	A	33904178	4	1	105	1	0	0	0	0	0	1	0	0	11740	1299	45	3	528	3	PEX12	17	33904178	Nonsense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	4271968	33904178	47291032	65	7264											
TEX14	56155	broad.mit.edu	37	chr17	56699012	56699012	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgctcaaggcagtactcaccCctgcacgaggcccccacacc	8	19	2	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr17:56699012C>A	uc010dcz.1	-	5	671	c.553G>T	c.(553-555)GGA>TGA	p.G185*	TEX14_uc002iwr.1_Nonsense_Mutation_p.G185*|TEX14_uc002iws.1_Nonsense_Mutation_p.G185*|TEX14_uc010dda.1_5'UTR	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	185						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGTACTCACCCCTGCACGAGG	0.612													A	56699012	A	A	56699012	4	1	105	1	0	0	0	0	0	1	0	0	15775	637	22	5	4038	5	TEX14	17	56699012	Nonsense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	22794834	56699012	24496198	66	7265											
TIMM44	10469	broad.mit.edu	37	chr19	7998999	7998999	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agagggctctgaaggccgctGtcctgcccagcttctccccg	12	16	2	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr19:7998999G>T	uc002miz.2	-	5	520	c.518C>A	c.(517-519)ACA>AAA	p.T173K	TIMM44_uc002mja.2_5'UTR|TIMM44_uc010dvx.1_RNA	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	173	ATP (Potential).				protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						GAAGGCCGCTGTCCTGCCCAG	0.677													T	7998999	T	T	7998999	3	4	105	1	0	0	0	0	1	0	0	0	15909	1377	48	5	876	5	TIMM44	19	7998999	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		7998999	51129984	67	7266											
SLC44A2	57153	broad.mit.edu	37	chr19	10748353	10748353	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgccaagtgcctcatgaCctgtctcaaatgctgcttct	8	12	3	1			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr19:10748353C>T	uc002mpf.2	+	17	1764	c.1625C>T	c.(1624-1626)ACC>ATC	p.T542I	SLC44A2_uc002mpe.3_Missense_Mutation_p.T540I|SLC44A2_uc002mpg.1_Missense_Mutation_p.T262I|SLC44A2_uc002mph.2_Missense_Mutation_p.T91I|SLC44A2_uc002mpi.2_5'Flank	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	542	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	TGCCTCATGACCTGTCTCAAA	0.527													T	10748353	T	T	10748353	3	4	105	1	0	0	0	0	1	0	0	0	14636	507	18	3	1726	3	SLC44A2	19	10748353	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	2749354	10748353	48380630	68	7267											
ZNF709	163051	broad.mit.edu	37	chr19	12575471	12575471	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctttaccacattgtttaCattcatggggtttctctcca	7	10	2	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr19:12575471C>T	uc002mtv.3	-	4	1426	c.1265G>A	c.(1264-1266)TGT>TAT	p.C422Y	ZNF709_uc002mtw.3_Missense_Mutation_p.C390Y|ZNF709_uc002mtx.3_Missense_Mutation_p.C422Y	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	422	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACATTGTTTACATTCATGGGG	0.408													T	12575471	T	T	12575471	3	4	105	1	0	0	0	0	1	0	0	0	18110	478	17	3	664	3	ZNF709	19	12575471	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08	1827118	12575471	46553512	69	7268											
ZNF570	148268	broad.mit.edu	37	chr19	37975633	37975633	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggaaagcatttagccttcGtgcataccttactgtacatc	8	10	0	0	rs146360083		TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr19:37975633G>A	uc002ogk.1	+	5	1638	c.1109G>A	c.(1108-1110)CGT>CAT	p.R370H	ZNF570_uc010efl.1_Missense_Mutation_p.R426H|ZNF570_uc010xtr.1_Missense_Mutation_p.R167H	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	370	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTAGCCTTCGTGCATACCTT	0.423													A	37975633	A	A	37975633	3	1	105	1	0	0	0	0	1	0	0	0	17999	1145	40	1	1123	1	ZNF570	19	37975633	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	25400162	37975633	21153350	70	7269											
LILRA5	353514	broad.mit.edu	37	chr19	54823844	54823844	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgagggcagggctcacggcGtctcctcccactggctgcag	14	14	2	1	rs143927346	byFrequency	TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr19:54823844G>A	uc002qfe.2	-	2	171	c.51C>T	c.(49-51)GAC>GAT	p.D17D	LILRA5_uc002qff.2_Silent_p.D17D|LILRA5_uc010yev.1_Silent_p.D17D|LILRA5_uc010yew.1_Silent_p.D17D|LILRA5_uc002qfh.1_Silent_p.D17D|LILRA5_uc002qfg.1_Silent_p.D17D	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	17					innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGCTCACGGCGTCTCCTCCCA	0.632													A	54823844	A	A	54823844	2	1	105	1	0	0	0	0	0	0	0	1	8788	1136	40	1		1	LILRA5	19	54823844	Silent	SNP	G	TCGA-06-6697-01A-11D-1845-08	16848211	54823844	4305139	71	7270											
PCSK2	5126	broad.mit.edu	37	chr20	17446060	17446060	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaggtccatcagtggcggcGcaatggggtcggcctggaat	17	10	1	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr20:17446060G>A	uc002wpm.2	+	11	1612	c.1292G>A	c.(1291-1293)CGC>CAC	p.R431H	PCSK2_uc002wpl.2_Missense_Mutation_p.R412H|PCSK2_uc010zrm.1_Missense_Mutation_p.R396H|PCSK2_uc002wpn.2_Missense_Mutation_p.R85H	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	431					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAGTGGCGGCGCAATGGGGTC	0.567													A	17446060	A	A	17446060	3	1	105	1	0	0	0	0	1	0	0	0	11601	1087	38	1	1334	1	PCSK2	20	17446060	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		17446060	45579460	72	7271											
SYCP2	10388	broad.mit.edu	37	chr20	58444912	58444912	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agattcaatttccataaaccGttcttctgaactataactgc	4	10	3	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr20:58444912G>A	uc002yaz.2	-	35	3821	c.3682C>T	c.(3682-3684)CGG>TGG	p.R1228W		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1228					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TCCATAAACCGTTCTTCTGAA	0.294													A	58444912	A	A	58444912	3	1	105	1	0	0	0	0	1	0	0	0	15429	1144	40	1	950	1	SYCP2	20	58444912	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	40998852	58444912	4580608	73	7272											
KRTAP10-7	386675	broad.mit.edu	37	chr21	46021295	46021295	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccggttcatgctgccagccAgcttgctgcacctcctccca	8	18	1	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr21:46021295A>C	uc002zfn.3	+	2	784	c.759A>C	c.(757-759)CCA>CCC	p.P253P	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198689	NP_941962	P60409	KR107_HUMAN	keratin associated protein 10-7	258	30 X 5 AA repeats of C-C-X(3).|20.					keratin filament					0						GCTGCCAGCCAGCTTGCTGCA	0.632													C	46021295	C	C	46021295	2	2	105	1	0	0	0	0	0	0	0	1	8514	175	7	5		5	KRTAP10-7	21	46021295	Silent	SNP	A	TCGA-06-6697-01A-11D-1845-08		46021295	2108600	74	7273											
LZTR1	8216	broad.mit.edu	37	chr22	21342314	21342314	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcagggggttacactggggAcatttattccaattctaact	9	9	2	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr22:21342314A>C	uc002zto.2	+	5	519	c.416A>C	c.(415-417)GAC>GCC	p.D139A	LZTR1_uc002ztn.2_Missense_Mutation_p.D98A|LZTR1_uc011ahy.1_Missense_Mutation_p.D120A|LZTR1_uc010gsr.1_Missense_Mutation_p.D10A	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	139	Kelch 2.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TACACTGGGGACATTTATTCC	0.453													C	21342314	C	C	21342314	3	2	105	1	0	0	0	0	1	0	0	0	9137	275	10	5	434	5	LZTR1	22	21342314	Missense_Mutation	SNP	A	TCGA-06-6697-01A-11D-1845-08		21342314	29962252	75	7274											
MYO18B	84700	broad.mit.edu	37	chr22	26348345	26348345	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aggcggtcatctgtgacctaGagaacaagacagagttccag	12	9	2	4			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr22:26348345G>C	uc003abz.1	+	38	6176	c.5926G>C	c.(5926-5928)GAG>CAG	p.E1976Q	MYO18B_uc003aca.1_Missense_Mutation_p.E1857Q|MYO18B_uc010guy.1_Missense_Mutation_p.E1858Q|MYO18B_uc010guz.1_Missense_Mutation_p.E1856Q|MYO18B_uc011aka.1_Missense_Mutation_p.E1130Q|MYO18B_uc011akb.1_Missense_Mutation_p.E1489Q|MYO18B_uc010gva.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1976	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CTGTGACCTAGAGAACAAGAC	0.517													C	26348345	C	C	26348345	3	2	105	1	0	0	0	0	1	0	0	0	10066	943	33	5	6072	5	MYO18B	22	26348345	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	5006031	26348345	24956221	76	7275											
SMC1B	27127	broad.mit.edu	37	chr22	45750854	45750854	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tttaccatctgtggactcttGaaacttgtctctgacagtct	7	10	4	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chr22:45750854G>C	uc003bgc.2	-	20	3155	c.3103C>G	c.(3103-3105)CAA>GAA	p.Q1035E	SMC1B_uc003bgd.2_Missense_Mutation_p.Q1035E	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	1035	Potential.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GTGGACTCTTGAAACTTGTCT	0.408													C	45750854	C	C	45750854	3	2	105	1	0	0	0	0	1	0	0	0	14782	1299	45	5	628	5	SMC1B	22	45750854	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08	19402509	45750854	5553712	77	7276											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299442	125299442	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgtcttggagggattcagctCgatggcatggatgccgcagc	15	10	2	0			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chrX:125299442C>T	uc004euk.1	-	1	493	c.466G>A	c.(466-468)GAG>AAG	p.E156K		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	156	WD 1.							p.E156K(1)		lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GGATTCAGCTCGATGGCATGG	0.682													T	125299442	T	T	125299442	3	4	105	1	0	0	0	0	1	0	0	0	4265	893	31	2	929	2	DCAF12L2	23	125299442	Missense_Mutation	SNP	C	TCGA-06-6697-01A-11D-1845-08		125299442	29971118	78	7277											
PCDH11Y	83259	broad.mit.edu	37	chrY	5605925	5605925	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgacaaccttcgctccacGccaacaggccagaccgtcca	7	17	0	2			TCGA-06-6697-01A-11D-1845-08	TCGA-06-6697-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d947ed1-1315-459e-b973-f3dd624d9e39	e9768b4f-626b-4f30-a864-af064338ed26	g.chrY:5605925G>A	uc004fqo.2	+	5	4699	c.3965G>A	c.(3964-3966)CGC>CAC	p.R1322H		NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	1322	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TTCGCTCCACGCCAACAGGCC	0.408													A	5605925	A	A	5605925	3	1	105	1	0	0	0	0	1	0	0	0	11509	1087	38	1	4041	1	PCDH11Y	24	5605925	Missense_Mutation	SNP	G	TCGA-06-6697-01A-11D-1845-08		5605925	53767641	79	7278											
ATAD3C	219293	broad.mit.edu	37	chr1	1392509	1392509	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcctccctctcgtccacagCctcctgctctttgtggatga	9	16	2	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr1:1392509C>T	uc001aft.2	+	8	1685	c.690C>T	c.(688-690)GGC>GGT	p.G230G		NM_001039211	NP_001034300	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	230							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCGTCCACAGCCTCCTGCTCT	0.642													T	1392509	T	T	1392509	2	4	106	1	0	0	0	0	0	0	0	1	1075	753	26	3		3	ATAD3C	1	1392509	Silent	SNP	C	TCGA-06-6698-01A-11D-1845-08		1392509	247858112	1	7279											
KAZ	23254	broad.mit.edu	37	chr1	15441012	15441012	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcttcagcagcaaagatcccGatttccatgatgactatggc	9	11	1	3			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr1:15441012G>A	uc001avm.3	+	15	2490	c.2209G>A	c.(2209-2211)GAT>AAT	p.D737N	C1orf126_uc001avv.3_RNA|C1orf126_uc009voh.2_RNA|KAZ_uc001avs.3_Missense_Mutation_p.D184N	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	737					keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						CAAAGATCCCGATTTCCATGA	0.493													A	15441012	A	A	15441012	3	1	106	1	0	0	0	0	1	0	0	0	7988	1058	37	2	2523	2	KAZ	1	15441012	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08	14048503	15441012	233809609	2	7280											
HP1BP3	50809	broad.mit.edu	37	chr1	21106349	21106349	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagcttgcttttgggaggaGtttcccgggtagaattcaca	12	8	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr1:21106349G>A	uc001bdw.1	-	3	292	c.152C>T	c.(151-153)ACT>ATT	p.T51I	HP1BP3_uc001bdv.1_Missense_Mutation_p.T13I|HP1BP3_uc010odh.1_Missense_Mutation_p.T13I|HP1BP3_uc001bdy.1_Missense_Mutation_p.T51I|HP1BP3_uc001bdz.2_RNA|HP1BP3_uc001bea.2_Missense_Mutation_p.T50I|HP1BP3_uc001beb.2_Missense_Mutation_p.T51I	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	51					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		TTTGGGAGGAGTTTCCCGGGT	0.403													A	21106349	A	A	21106349	3	1	106	1	0	0	0	0	1	0	0	0	7328	1029	36	3	1553	3	HP1BP3	1	21106349	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08	5665337	21106349	228144272	3	7281											
PEX11B	8799	broad.mit.edu	37	chr1	145517332	145517332	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagaggcatggagccagtcCtgagttacagaaacagattc	12	9	0	4			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr1:145517332C>T	uc001eny.1	+	2	134	c.116C>T	c.(115-117)CCT>CTT	p.P39L	NBPF10_uc001emp.3_Intron|GNRHR2_uc009wiv.1_5'Flank|GNRHR2_uc010oyt.1_5'Flank|GNRHR2_uc001enx.2_5'Flank|PEX11B_uc010oyu.1_Missense_Mutation_p.P25L	NM_003846	NP_003837	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	39					peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGAGCCAGTCCTGAGTTACAG	0.537													T	145517332	T	T	145517332	3	4	106	1	0	0	0	0	1	0	0	0	11738	681	24	3	140	3	PEX11B	1	145517332	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	124410983	145517332	103733289	4	7282											
IQGAP3	128239	broad.mit.edu	37	chr1	156524129	156524129	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctccagggcccggttaatcAggaccacagctgagagcatc	11	14	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr1:156524129A>G	uc001fpf.2	-	13	1421	c.1346T>C	c.(1345-1347)CTG>CCG	p.L449P	IQGAP3_uc009wsb.1_Missense_Mutation_p.L406P	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	449					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCGGTTAATCAGGACCACAGC	0.622													G	156524129	G	G	156524129	3	3	106	1	0	0	0	0	1	0	0	0	7816	188	7	4	3653	4	IQGAP3	1	156524129	Missense_Mutation	SNP	A	TCGA-06-6698-01A-11D-1845-08	11006797	156524129	92726492	5	7283											
C1orf125	126859	broad.mit.edu	37	chr1	179460808	179460808	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aacatgatataggagttgcgCgattggagctagatgcgatt	13	5	0	2			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr1:179460808C>G	uc001gmo.2	+	19	2354	c.2227C>G	c.(2227-2229)CGA>GGA	p.R743G	C1orf125_uc009wxg.2_RNA|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.R743G|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	743											0						AGGAGTTGCGCGATTGGAGCT	0.413													G	179460808	G	G	179460808	3	3	106	1	0	0	0	0	1	0	0	0	1993	760	27	5	2297	5	C1orf125	1	179460808	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	22936679	179460808	69789813	6	7284											
F13B	2165	broad.mit.edu	37	chr1	197021962	197021962	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccacattaacagtacatgGttctgtaaaacaaaatgctc	5	9	1	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr1:197021962G>A	uc001gtt.1	-	9	1401	c.1357C>T	c.(1357-1359)CCA>TCA	p.P453S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	453	Sushi 8.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ACAGTACATGGTTCTGTAAAA	0.259													A	197021962	A	A	197021962	3	1	106	1	0	0	0	0	1	0	0	0	5341	1261	44	3	644	3	F13B	1	197021962	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08	17561154	197021962	52228659	7	7285											
SMARCAL1	50485	broad.mit.edu	37	chr2	217285033	217285033	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttggcagtgaaagcagccCagagcctccccacggtcaac	10	15	1	2			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr2:217285033C>T	uc002vgc.3	+	5	1204	c.874C>T	c.(874-876)CAG>TAG	p.Q292*	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Nonsense_Mutation_p.Q292*|SMARCAL1_uc010fvg.2_Nonsense_Mutation_p.Q292*	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	292	HARP 1.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		GAAAGCAGCCCAGAGCCTCCC	0.557									Schimke_Immuno-Osseous_Dysplasia				T	217285033	T	T	217285033	4	4	106	1	0	0	0	0	0	1	0	0	14773	595	21	3	884	3	SMARCAL1	2	217285033	Nonsense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08		217285033	25914340	8	7286											
PIK3CB	5291	broad.mit.edu	37	chr3	138374298	138374298	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagtagtccagctttccctgAgcgcctcatcaaatttttgc	7	12	2	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr3:138374298A>C	uc011bmq.1	-	22	3146	c.3146T>G	c.(3145-3147)CTC>CGC	p.L1049R	PIK3CB_uc011bmn.1_Missense_Mutation_p.L561R|PIK3CB_uc011bmo.1_Missense_Mutation_p.L500R|PIK3CB_uc011bmp.1_Missense_Mutation_p.L636R|PIK3CB_uc003est.1_RNA	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	1049	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GCTTTCCCTGAGCGCCTCATC	0.418													C	138374298	C	C	138374298	3	2	106	1	0	0	0	0	1	0	0	0	11914	304	11	5	68	5	PIK3CB	3	138374298	Missense_Mutation	SNP	A	TCGA-06-6698-01A-11D-1845-08		138374298	59648132	9	7287											
RBM47	54502	broad.mit.edu	37	chr4	40440532	40440532	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgttgagctcacgcactgCgcgcttggcctcgtgcttgt	13	12	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr4:40440532C>T	uc003gvc.2	-	4	1089	c.379G>A	c.(379-381)GCA>ACA	p.A127T	RBM47_uc003gvd.2_Missense_Mutation_p.A127T|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.A89T|RBM47_uc003gvg.1_Missense_Mutation_p.A127T	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	127	RRM 1.					nucleus	nucleotide binding|RNA binding			breast(3)	3						TCACGCACTGCGCGCTTGGCC	0.642													T	40440532	T	T	40440532	3	4	106	1	0	0	0	0	1	0	0	0	13141	768	27	1	1418	1	RBM47	4	40440532	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08		40440532	150713744	10	7288											
FYB	2533	broad.mit.edu	37	chr5	39202820	39202820	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctccagtgggctttagaaaCgggggcttgggttccttgtc	15	9	0	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr5:39202820C>T	uc003jls.2	-	1	310	c.243G>A	c.(241-243)CCG>CCA	p.P81P	FYB_uc003jlt.2_Silent_p.P81P|FYB_uc003jlu.2_Silent_p.P81P|FYB_uc011cpl.1_Silent_p.P91P	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	81					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			GCTTTAGAAACGGGGGCTTGG	0.552													T	39202820	T	T	39202820	2	4	106	1	0	0	0	0	0	0	0	1	6124	523	19	1		1	FYB	5	39202820	Silent	SNP	C	TCGA-06-6698-01A-11D-1845-08		39202820	141712440	11	7289											
NUDT12	83594	broad.mit.edu	37	chr5	102891710	102891710	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acataatctcttatagccacCttcttcaattttagttgcat	3	10	3	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr5:102891710C>T	uc003koi.2	-	4	979	c.886G>A	c.(886-888)GGT>AGT	p.G296S	NUDT12_uc011cvb.1_Missense_Mutation_p.G278S	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	296						nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		TTATAGCCACCTTCTTCAATT	0.393													T	102891710	T	T	102891710	3	4	106	1	0	0	0	0	1	0	0	0	10728	681	24	3	518	3	NUDT12	5	102891710	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	63688890	102891710	78023550	12	7290											
PCDHGA1	56114	broad.mit.edu	37	chr5	140711002	140711002	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcacaataccatataaatGtccccgaaaacgtgccgctg	8	12	0	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr5:140711002G>A	uc003lji.1	+	1	751	c.751G>A	c.(751-753)GTC>ATC	p.V251I	PCDHGA1_uc011dan.1_Missense_Mutation_p.V251I	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	251	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATATAAATGTCCCCGAAAA	0.493													A	140711002	A	A	140711002	3	1	106	1	0	0	0	0	1	0	0	0	11550	1377	48	3	753	3	PCDHGA1	5	140711002	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08	37819292	140711002	40204258	13	7291											
RUFY1	80230	broad.mit.edu	37	chr5	179036447	179036447	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgagctggccctgccctcctAccccaagccggtgcgagtgt	12	17	0	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr5:179036447A>C	uc003mka.1	+	18	2054	c.2054A>C	c.(2053-2055)TAC>TCC	p.Y685S	RUFY1_uc003mkb.1_Missense_Mutation_p.Y577S|RUFY1_uc003mkc.1_Missense_Mutation_p.Y577S|RUFY1_uc003mkd.1_Missense_Mutation_p.Y287S	NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	685	FYVE-type.				endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGCCCTCCTACCCCAAGCCG	0.647										HNSCC(44;0.11)			C	179036447	C	C	179036447	3	2	106	1	0	0	0	0	1	0	0	0	13738	391	14	5	2124	5	RUFY1	5	179036447	Missense_Mutation	SNP	A	TCGA-06-6698-01A-11D-1845-08	38325445	179036447	1878813	14	7292											
CARD11	84433	broad.mit.edu	37	chr7	2951813	2951813	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccccgcctcaccttggcgGccacagcttcaatgttggca	10	16	2	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr7:2951813G>A	uc003smv.2	-	23	3541	c.3137C>T	c.(3136-3138)GCC>GTC	p.A1046V		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	1046	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CACCTTGGCGGCCACAGCTTC	0.602			Mis		DLBCL								A	2951813	A	A	2951813	3	1	106	1	0	0	0	0	1	0	0	0	2645	1203	42	3	339	3	CARD11	7	2951813	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08		2951813	156186850	15	7293											
NXPH1	30010	broad.mit.edu	37	chr7	8791355	8791355	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tggtacagaaagtgtgccctGactacaactaccacagtgac	9	11	0	3			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr7:8791355G>A	uc003srv.2	+	3	1683	c.772G>A	c.(772-774)GAC>AAC	p.D258N	NXPH1_uc011jxh.1_Missense_Mutation_p.D141N	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	258	V (Cys-rich).					extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		AGTGTGCCCTGACTACAACTA	0.443													A	8791355	A	A	8791355	3	1	106	1	0	0	0	0	1	0	0	0	10790	1290	45	3	778	3	NXPH1	7	8791355	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08	5839542	8791355	150347308	16	7294											
ZNF713	349075	broad.mit.edu	37	chr7	56007178	56007178	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaaggccttcagccacaccTcatctcttagccagcctcag	8	16	4	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr7:56007178T>C	uc003trc.1	+	4	810	c.772T>C	c.(772-774)TCA>CCA	p.S258P	ZNF713_uc003tra.1_Missense_Mutation_p.S271P|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CAGCCACACCTCATCTCTTAG	0.423													C	56007178	C	C	56007178	3	2	106	1	0	0	0	0	1	0	0	0	18114	1551	54	4	786	4	ZNF713	7	56007178	Missense_Mutation	SNP	T	TCGA-06-6698-01A-11D-1845-08	47215823	56007178	103131485	17	7295											
AHCYL2	23382	broad.mit.edu	37	chr7	129062691	129062691	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtgttccaggcgagtctgcGgacaccagaactgacctggg	14	11	1	2			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr7:129062691G>T	uc011kov.1	+	13	1526	c.1472G>T	c.(1471-1473)CGG>CTG	p.R491L	AHCYL2_uc003vot.2_Missense_Mutation_p.R490L|AHCYL2_uc003vov.2_Missense_Mutation_p.R388L|AHCYL2_uc011kow.1_Missense_Mutation_p.R389L|AHCYL2_uc011kox.1_Missense_Mutation_p.R388L	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	491					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GCGAGTCTGCGGACACCAGAA	0.507													T	129062691	T	T	129062691	3	4	106	1	0	0	0	0	1	0	0	0	411	1116	39	5	1644	5	AHCYL2	7	129062691	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08	73055513	129062691	30075972	18	7296											
TP53INP1	94241	broad.mit.edu	37	chr8	95952365	95952365	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agatgccggtaaacaggaaaAgactgaagggtgctcagtag	14	6	1	3			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr8:95952365A>G	uc003yhg.2	-	3	580	c.196T>C	c.(196-198)TTT>CTT	p.F66L	C8orf38_uc003yhe.1_Intron|C8orf38_uc003yhf.2_Intron|TP53INP1_uc003yhh.2_Missense_Mutation_p.F66L	NM_033285	NP_150601	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	66					apoptosis	PML body					0	Breast(36;8.75e-07)					AAACAGGAAAAGACTGAAGGG	0.463													G	95952365	G	G	95952365	3	3	106	1	0	0	0	0	1	0	0	0	16385	72	3	4	560	4	TP53INP1	8	95952365	Missense_Mutation	SNP	A	TCGA-06-6698-01A-11D-1845-08		95952365	50411657	19	7297											
WDR67	93594	broad.mit.edu	37	chr8	124140520	124140521	+	Splice_Site	INS	-	T	T													aacaccaagttttcttacagINStttttttttcaccatcggaa							TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr8:124140520_124140521insT	uc003ypp.1	+	14	1975	c.1885_splice	c.e14-1	p.F629_splice	WDR67_uc011lig.1_Splice_Site_p.F629_splice|WDR67_uc011lih.1_Splice_Site_p.F519_splice|WDR67_uc003ypq.1_Splice_Site|WDR67_uc003yps.1_Intron|WDR67_uc003ypt.1_Splice_Site_p.F86_splice|WDR67_uc003ypu.1_Splice_Site_p.F86_splice	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1							centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TTTTCTTACAGTTTTTTTTTCA	0.322													T	124140521	T	T	124140520	8	5	106	1	0	1	1	0	0	0	1	0	17315	1043	36	0	1938	0	WDR67	8	124140520	Splice_Site	INS	-	TCGA-06-6698-01A-11D-1845-08	28188155	124140520	22223502	20	7298											
CYP11B1	1584	broad.mit.edu	37	chr8	143956491	143956491	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agcccctgatgtctagccagCgctgggggttatagcgctca	13	12	2	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr8:143956491C>G	uc003yxi.2	-	8	1287	c.1280G>C	c.(1279-1281)CGC>CCC	p.R427P	CYP11B1_uc010mex.2_Missense_Mutation_p.R126P|CYP11B1_uc003yxh.2_Intron|CYP11B1_uc003yxj.2_Intron|CYP11B1_uc010mey.2_Missense_Mutation_p.R498P	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	427					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GTCTAGCCAGCGCTGGGGGTT	0.647									Familial_Hyperaldosteronism_type_I				G	143956491	G	G	143956491	3	3	106	1	0	0	0	0	1	0	0	0	4145	768	27	5	239	5	CYP11B1	8	143956491	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	19815971	143956491	2407531	21	7299											
C9orf64	84267	broad.mit.edu	37	chr9	86571236	86571236	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagttgaccgcggcctcgtcGgccgccctggggttcagctc	14	16	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr9:86571236G>A	uc004anb.2	-	1	428	c.180C>T	c.(178-180)GCC>GCT	p.A60A	C9orf64_uc004anc.2_Intron	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	60											0						CGGCCTCGTCGGCCGCCCTGG	0.647													A	86571236	A	A	86571236	2	1	106	1	0	0	0	0	0	0	0	1	2489	1103	39	2		2	C9orf64	9	86571236	Silent	SNP	G	TCGA-06-6698-01A-11D-1845-08		86571236	54642195	22	7300											
SEC16A	9919	broad.mit.edu	37	chr9	139369673	139369673	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ggactgaagggcctcctcctCtcccattttgggaggattct	11	12	2	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr9:139369673C>G	uc004chx.2	-	3	2704	c.2395G>C	c.(2395-2397)GAG>CAG	p.E799Q	SEC16A_uc004chv.3_Missense_Mutation_p.E426Q|SEC16A_uc004chw.2_Missense_Mutation_p.E799Q|SEC16A_uc010nbn.2_Missense_Mutation_p.E799Q|SEC16A_uc010nbo.1_Missense_Mutation_p.E799Q	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	621					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GCCTCCTCCTCTCCCATTTTG	0.572													G	139369673	G	G	139369673	3	3	106	1	0	0	0	0	1	0	0	0	13986	922	32	5	4798	5	SEC16A	9	139369673	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	52798437	139369673	1843758	23	7301											
RBP3	5949	broad.mit.edu	37	chr10	48389610	48389610	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acacagagtccaccagtgctTgccggatagcctcgtcctca	9	15	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr10:48389610T>A	uc001jez.2	-	1	1382	c.1268A>T	c.(1267-1269)CAA>CTA	p.Q423L		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	423	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CACCAGTGCTTGCCGGATAGC	0.627													A	48389610	A	A	48389610	3	1	106	1	0	0	0	0	1	0	0	0	13157	1812	63	5	2491	5	RBP3	10	48389610	Missense_Mutation	SNP	T	TCGA-06-6698-01A-11D-1845-08		48389610	87145137	24	7302											
OR51F1	256892	broad.mit.edu	37	chr11	4790374	4790374	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cgatacaccaaggacaggctCagcatgtggatgtagaagaa	12	8	1	2			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr11:4790374C>T	uc010qyl.1	-	1	774	c.774G>A	c.(772-774)CTG>CTA	p.L258L		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	258						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		AGGACAGGCTCAGCATGTGGA	0.522													T	4790374	T	T	4790374	2	4	106	1	0	0	0	0	0	0	0	1	11096	813	29	3		3	OR51F1	11	4790374	Silent	SNP	C	TCGA-06-6698-01A-11D-1845-08		4790374	130216142	25	7303											
SLC22A25	387601	broad.mit.edu	37	chr11	62985164	62985164	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcacaggtgcctacaatggCgagctggaggtaagaccatc	13	11	0	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr11:62985164C>T	uc001nwr.1	-	3	550	c.550G>A	c.(550-552)GCC>ACC	p.A184T	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_Intron|SLC22A25_uc001nwt.1_Missense_Mutation_p.A184T	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	184	Helical; Name=3; (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						CCTACAATGGCGAGCTGGAGG	0.488													T	62985164	T	T	62985164	3	4	106	1	0	0	0	0	1	0	0	0	14454	768	27	1	1121	1	SLC22A25	11	62985164	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	58194790	62985164	72021352	26	7304											
NLRX1	79671	broad.mit.edu	37	chr11	119052983	119052983	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagctgaacgtggcgtacaaCggtgctggtgacacagcggc	16	10	0	2			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr11:119052983C>T	uc001pvu.2	+	9	2750	c.2535C>T	c.(2533-2535)AAC>AAT	p.N845N	NLRX1_uc001pvv.2_Silent_p.N845N|NLRX1_uc001pvw.2_Silent_p.N845N|NLRX1_uc001pvx.2_Silent_p.N845N	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	845	LRR 6.|Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGGCGTACAACGGTGCTGGTG	0.677													T	119052983	T	T	119052983	2	4	106	1	0	0	0	0	0	0	0	1	10485	535	19	1		1	NLRX1	11	119052983	Silent	SNP	C	TCGA-06-6698-01A-11D-1845-08	56067819	119052983	15953533	27	7305											
ARHGEF12	23365	broad.mit.edu	37	chr11	120352059	120352059	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttaccctgcagcccatgaCaggcatccctgctgtggaat	9	14	0	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr11:120352059C>T	uc001pxl.1	+	39	4335	c.4328C>T	c.(4327-4329)ACA>ATA	p.T1443I	ARHGEF12_uc009zau.1_Missense_Mutation_p.T1340I	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1443					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CAGCCCATGACAGGCATCCCT	0.512			T	MLL	AML								T	120352059	T	T	120352059	3	4	106	1	0	0	0	0	1	0	0	0	897	478	17	3	4482	3	ARHGEF12	11	120352059	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	1299076	120352059	14654457	28	7306											
C1QL4	338761	broad.mit.edu	37	chr12	49726939	49726939	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgaagacctcgtcgcccacGtccaggtgcagaatgacgct	11	13	0	4			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr12:49726939G>A	uc001rtz.1	-	2	1326	c.615C>T	c.(613-615)GAC>GAT	p.D205D		NM_001008223	NP_001008224	Q86Z23	C1QL4_HUMAN	complement component 1, q subcomponent-like 4	205	C1q.					collagen					0						CGTCGCCCACGTCCAGGTGCA	0.597													A	49726939	A	A	49726939	2	1	106	1	0	0	0	0	0	0	0	1	1961	1136	40	1		1	C1QL4	12	49726939	Silent	SNP	G	TCGA-06-6698-01A-11D-1845-08		49726939	84124956	29	7307											
NHLRC3	387921	broad.mit.edu	37	chr13	39613426	39613426	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattggtttacataggtcaaGtaagtaaatagagatttaaa	9	2	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr13:39613426G>A	uc001uxc.2	+	2	559	c.237_splice	c.e2+1	p.Q79_splice	C13orf23_uc001uwy.2_5'Flank|C13orf23_uc001uwz.2_5'Flank|NHLRC3_uc001uxa.1_Splice_Site_p.Q79_splice|NHLRC3_uc001uxb.1_Splice_Site_p.Q79_splice|NHLRC3_uc001uxd.2_Splice_Site_p.Q79_splice|NHLRC3_uc001uxe.2_Splice_Site	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a							extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		CATAGGTCAAGTAAGTAAATA	0.388													A	39613426	A	A	39613426	5	1	106	1	0	0	0	0	0	0	1	0	10407	1043	36	3	244	3	NHLRC3	13	39613426	Splice_Site	SNP	G	TCGA-06-6698-01A-11D-1845-08		39613426	75556452	30	7308											
RB1	5925	broad.mit.edu	37	chr13	48916734	48916734	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctttattttttgttcccaGggaggttatattcaaaagaa	7	5	2	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr13:48916734G>A	uc001vcb.2	+	3	431	c.265_splice	c.e3-1	p.G89_splice	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(2)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTGTTCCCAGGGAGGTTATA	0.318		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			A	48916734	A	A	48916734	5	1	106	1	0	0	0	0	0	0	1	0	13098	1014	35	3	274	3	RB1	13	48916734	Splice_Site	SNP	G	TCGA-06-6698-01A-11D-1845-08	9303308	48916734	66253144	31	7309											
RB1	5925	broad.mit.edu	37	chr13	48941638	48941641	+	Frame_Shift_Del	DEL	TCTT	-	-													ttttctttcaaggttgaaaaTctttctaaacgatacgaaga							TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr13:48941638_48941641delTCTT	uc001vcb.2	+	10	1114_1117	c.948_951delTCTT	c.(946-951)AATCTTfs	p.N316fs	RB1_uc010act.1_Frame_Shift_Del_p.N17fs	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	316_317					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGGTTGAAAATCTTTCTAAACGAT	0.299		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			-	48941641	-	-	48941638	7	5	106	1	0	1	0	1	0	0	0	0	13098	1432	50	0	986	0	RB1	13	48941638	Frame_Shift_Del	DEL	TCTT	TCGA-06-6698-01A-11D-1845-08	24904	48941638	66228240	32	7310											
MTA1	9112	broad.mit.edu	37	chr14	105936268	105936268	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgcccccagtcaagcggCggcggatgaactggatcgac	13	15	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr14:105936268C>T	uc001yqx.2	+	20	2123	c.1936C>T	c.(1936-1938)CGG>TGG	p.R646W	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Missense_Mutation_p.R411W	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	646					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		AGTCAAGCGGCGGCGGATGAA	0.677													T	105936268	T	T	105936268	3	4	106	1	0	0	0	0	1	0	0	0	9908	759	27	1	2014	1	MTA1	14	105936268	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08		105936268	1413272	33	7311											
TSC2	7249	broad.mit.edu	37	chr16	2134716	2134716	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgccaggcatcaaccccaGgtgggcctcttgcttccggg	13	14	2	0	rs137854879		TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr16:2134716G>A	uc002con.2	+	34	4599	c.4493G>A	c.(4492-4494)AGT>AAT	p.S1498N	TSC2_uc010bsd.2_Missense_Mutation_p.S1475N|TSC2_uc002coo.2_Missense_Mutation_p.S1431N|TSC2_uc010uvv.1_Missense_Mutation_p.S1395N|TSC2_uc010uvw.1_Missense_Mutation_p.S1383N|TSC2_uc002cop.2_Missense_Mutation_p.S1254N|TSC2_uc002coq.2_Missense_Mutation_p.S273N|TSC2_uc002cor.2_Missense_Mutation_p.S199N	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1498			S -> N (in TSC2).		cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				ATCAACCCCAGGTGGGCCTCT	0.662			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				A	2134716	A	A	2134716	3	1	106	1	0	0	0	0	1	0	0	0	16603	1014	35	3	4623	3	TSC2	16	2134716	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08		2134716	88220037	34	7312											
GRIN2A	2903	broad.mit.edu	37	chr16	9862916	9862916	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgttgtggcagatcccagtgAgccacagggtctccagctcc	12	14	1	2			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr16:9862916A>T	uc002czo.3	-	12	2935	c.2387T>A	c.(2386-2388)CTC>CAC	p.L796H	GRIN2A_uc010uym.1_Missense_Mutation_p.L796H|GRIN2A_uc010uyn.1_Missense_Mutation_p.L639H|GRIN2A_uc002czr.3_Missense_Mutation_p.L796H	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	796	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATCCCAGTGAGCCACAGGGT	0.478													T	9862916	T	T	9862916	3	4	106	1	0	0	0	0	1	0	0	0	6779	304	11	5	2015	5	GRIN2A	16	9862916	Missense_Mutation	SNP	A	TCGA-06-6698-01A-11D-1845-08	7728200	9862916	80491837	35	7313											
IL4R	3566	broad.mit.edu	37	chr16	27373977	27373977	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggagtcatgccttcttccacCttcgggaagtacgagtgctc	11	12	2	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr16:27373977C>G	uc002don.2	+	11	1546	c.1304C>G	c.(1303-1305)CCT>CGT	p.P435R	IL4R_uc002dop.3_Missense_Mutation_p.P420R|IL4R_uc010bxy.2_Missense_Mutation_p.P435R|IL4R_uc002doo.2_Missense_Mutation_p.P275R	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	435	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						CTTCTTCCACCTTCGGGAAGT	0.612													G	27373977	G	G	27373977	3	3	106	1	0	0	0	0	1	0	0	0	7698	681	24	5	1356	5	IL4R	16	27373977	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	17511061	27373977	62980776	36	7314											
CDH8	1006	broad.mit.edu	37	chr16	61689535	61689535	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tgctgctcagtggaggatttCcactatcactgattatgatt	9	8	2	2			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr16:61689535C>A	uc002eog.1	-	11	1997	c.1745G>T	c.(1744-1746)GGA>GTA	p.G582V		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	582	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TGGAGGATTTCCACTATCACT	0.438													A	61689535	A	A	61689535	3	1	106	1	0	0	0	0	1	0	0	0	3116	855	30	5	662	5	CDH8	16	61689535	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	34315558	61689535	28665218	37	7315											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	13	14	3	0	rs28934578		TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578406	T	T	7578406	3	4	106	1	0	0	0	0	1	0	0	0	16378	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08		7578406	73616804	38	7316											
KCNJ12	3768	broad.mit.edu	37	chr17	21318689	21318689	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgggccaacccctacagcaTcgtgtcatcggaggaggacg	13	14	1	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr17:21318689T>G	uc002gyv.1	+	3	740	c.35T>G	c.(34-36)ATC>AGC	p.I12S		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	12	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCCTACAGCATCGTGTCATCG	0.711										Prostate(3;0.18)			G	21318689	G	G	21318689	3	3	106	1	0	0	0	0	1	0	0	0	8046	1435	50	5	37	5	KCNJ12	17	21318689	Missense_Mutation	SNP	T	TCGA-06-6698-01A-11D-1845-08	13740283	21318689	59876521	39	7317											
NF1	4763	broad.mit.edu	37	chr17	29661898	29661898	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttggaatacatgactccatGgctgtcaaatctagttcgtt	8	8	2	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr17:29661898G>A	uc002hgg.2	+	40	6188	c.5855G>A	c.(5854-5856)TGG>TAG	p.W1952*	NF1_uc002hgh.2_Nonsense_Mutation_p.W1931*|NF1_uc010cso.2_Nonsense_Mutation_p.W140*|NF1_uc010wbt.1_5'Flank|NF1_uc010wbu.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1952			W -> R (in NF1).		actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATGACTCCATGGCTGTCAAAT	0.343			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29661898	A	A	29661898	4	1	106	1	0	0	0	0	0	1	0	0	10356	1357	47	3	6074	3	NF1	17	29661898	Nonsense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08	8343209	29661898	51533312	40	7318											
EFTUD2	9343	broad.mit.edu	37	chr17	42942379	42942379	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctcctccttcgtcaggtGgatgccaagctcgtctaggg	12	13	2	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr17:42942379G>A	uc002ihn.2	-	14	1465	c.1204C>T	c.(1204-1206)CAC>TAC	p.H402Y	EFTUD2_uc010wje.1_Missense_Mutation_p.H367Y|EFTUD2_uc010wjf.1_Missense_Mutation_p.H392Y	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	402						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				TTCGTCAGGTGGATGCCAAGC	0.557											OREG0024466	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	42942379	A	A	42942379	3	1	106	1	0	0	0	0	1	0	0	0	4961	1348	47	3	1774	3	EFTUD2	17	42942379	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08	13280481	42942379	38252831	41	7319											
LPO	4025	broad.mit.edu	37	chr17	56344837	56344837	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tacgggacccctgacaacatCgacatctggataggggccat	11	12	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr17:56344837C>T	uc002ivt.2	+	12	2137	c.1821C>T	c.(1819-1821)ATC>ATT	p.I607I	LPO_uc010wns.1_Silent_p.I548I|LPO_uc010dcp.2_Silent_p.I524I|LPO_uc010dcq.2_Silent_p.I278I|LPO_uc010dcr.2_Silent_p.I170I	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	607					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						CTGACAACATCGACATCTGGA	0.587													T	56344837	T	T	56344837	2	4	106	1	0	0	0	0	0	0	0	1	8922	874	31	2		2	LPO	17	56344837	Silent	SNP	C	TCGA-06-6698-01A-11D-1845-08	13402458	56344837	24850373	42	7320											
ALPK2	115701	broad.mit.edu	37	chr18	56203541	56203541	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gactgtgagccaatgctgctAtttcagagggggccaattca	12	9	2	2			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr18:56203541A>G	uc002lhj.3	-	5	4092	c.3878T>C	c.(3877-3879)ATA>ACA	p.I1293T	ALPK2_uc002lhk.1_Missense_Mutation_p.I624T	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1293							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CAATGCTGCTATTTCAGAGGG	0.507													G	56203541	G	G	56203541	3	3	106	1	0	0	0	0	1	0	0	0	545	449	16	4	2670	4	ALPK2	18	56203541	Missense_Mutation	SNP	A	TCGA-06-6698-01A-11D-1845-08		56203541	21873707	43	7321											
SERPINB7	8710	broad.mit.edu	37	chr18	61471670	61471670	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggattgcttcggggggtcGtctgtatatatcaaggatga	15	5	2	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr18:61471670G>A	uc002ljl.2	+	8	1040	c.944G>A	c.(943-945)CGT>CAT	p.R315H	SERPINB7_uc002ljm.2_Missense_Mutation_p.R315H|SERPINB7_uc010xet.1_Missense_Mutation_p.R298H|SERPINB7_uc010dqg.2_Missense_Mutation_p.R315H	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	315					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity	p.R315H(1)		lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				TCGGGGGGTCGTCTGTATATA	0.428													A	61471670	A	A	61471670	3	1	106	1	0	0	0	0	1	0	0	0	14106	1145	40	1	970	1	SERPINB7	18	61471670	Missense_Mutation	SNP	G	TCGA-06-6698-01A-11D-1845-08	5268129	61471670	16605578	44	7322											
KCNG2	26251	broad.mit.edu	37	chr18	77624159	77624159	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcggccggcggcgcctgcgCgacgtggtggacaacccgca	17	16	0	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr18:77624159C>T	uc010xfl.1	+	1	492	c.492C>T	c.(490-492)CGC>CGT	p.R164R		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	164	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		ggcgccTGCGCGACGTGGTGG	0.368													T	77624159	T	T	77624159	2	4	106	1	0	0	0	0	0	0	0	1	8028	755	27	1		1	KCNG2	18	77624159	Silent	SNP	C	TCGA-06-6698-01A-11D-1845-08	16152489	77624159	453089	45	7323											
CD209	30835	broad.mit.edu	37	chr19	7812212	7812212	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgctaagctcttgtatcctCgagtctgtcggaatccaagg	10	11	2	0			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr19:7812212C>T	uc002mht.2	-	2	153	c.86G>A	c.(85-87)CGA>CAA	p.R29Q	CD209_uc010xju.1_Missense_Mutation_p.R29Q|CD209_uc010dvp.2_Missense_Mutation_p.R29Q|CD209_uc002mhr.2_Missense_Mutation_p.R29Q|CD209_uc002mhs.2_Missense_Mutation_p.R29Q|CD209_uc002mhu.2_Missense_Mutation_p.R29Q|CD209_uc010dvq.2_Missense_Mutation_p.R29Q|CD209_uc002mhq.2_Missense_Mutation_p.R29Q|CD209_uc002mhv.2_Missense_Mutation_p.R29Q|CD209_uc002mhx.2_Intron|CD209_uc002mhw.2_Intron|CD209_uc010dvr.2_Missense_Mutation_p.R29Q	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	29	Cytoplasmic (Probable).				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						CTTGTATCCTCGAGTCTGTCG	0.378													T	7812212	T	T	7812212	3	4	106	1	0	0	0	0	1	0	0	0	2984	884	31	2	1152	2	CD209	19	7812212	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08		7812212	51316771	46	7324											
IGFL1	374918	broad.mit.edu	37	chr19	46733408	46733408	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccaggctcctctgctcacaCggagccccaggtgagcccag	11	17	2	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr19:46733408C>T	uc002pee.2	+	2	92	c.69C>T	c.(67-69)CAC>CAT	p.H23H		NM_198541	NP_940943	Q6UW32	IGFL1_HUMAN	IGF-like family member 1 precursor	23						extracellular space	protein binding				0		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.00242)|all cancers(93;0.0132)|GBM - Glioblastoma multiforme(486;0.0294)|Epithelial(262;0.201)		TCTGCTCACACGGAGCCCCAG	0.597													T	46733408	T	T	46733408	2	4	106	1	0	0	0	0	0	0	0	1	7586	535	19	1		1	IGFL1	19	46733408	Silent	SNP	C	TCGA-06-6698-01A-11D-1845-08	38921196	46733408	12395575	47	7325											
KLK6	5653	broad.mit.edu	37	chr19	51462532	51462532	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	taccccatgacacaaggcctCggaggtggtctccacatacc	9	15	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr19:51462532C>T	uc002pui.2	-	7	883	c.623G>A	c.(622-624)CGA>CAA	p.R208Q	KLK6_uc010eoj.2_Missense_Mutation_p.E80K|KLK6_uc002puh.2_Missense_Mutation_p.R217Q|KLK6_uc002puj.2_Missense_Mutation_p.R101Q|KLK6_uc010ycn.1_Missense_Mutation_p.R101Q|KLK6_uc002pul.2_Missense_Mutation_p.R208Q|KLK6_uc002pum.2_Missense_Mutation_p.R101Q	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	208	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		CACAAGGCCTCGGAGGTGGTC	0.393													T	51462532	T	T	51462532	3	4	106	1	0	0	0	0	1	0	0	0	8408	884	31	2	115	2	KLK6	19	51462532	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08	4729124	51462532	7666451	48	7326											
TSHZ2	128553	broad.mit.edu	37	chr20	51870294	51870294	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcggacatcaagagtgtctgCggcagagatgcctcagacaa	12	10	3	3			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr20:51870294C>T	uc002xwo.2	+	2	1253	c.297C>T	c.(295-297)TGC>TGT	p.C99C		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	99					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AGAGTGTCTGCGGCAGAGATG	0.512													T	51870294	T	T	51870294	2	4	106	1	0	0	0	0	0	0	0	1	16621	776	27	1		1	TSHZ2	20	51870294	Silent	SNP	C	TCGA-06-6698-01A-11D-1845-08		51870294	11155226	49	7327											
RRP1B	23076	broad.mit.edu	37	chr21	45092195	45092195	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccccgcctctgcaggaagagCtcgccaacaccattgcacag	9	17	1	1			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chr21:45092195C>A	uc002zdk.2	+	3	334	c.220C>A	c.(220-222)CTC>ATC	p.L74I		NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	74					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		GCAGGAAGAGCTCGCCAACAC	0.552													A	45092195	A	A	45092195	3	1	106	1	0	0	0	0	1	0	0	0	13688	797	28	5	230	5	RRP1B	21	45092195	Missense_Mutation	SNP	C	TCGA-06-6698-01A-11D-1845-08		45092195	3037700	50	7328											
MAGT1	84061	broad.mit.edu	37	chrX	77109426	77109426	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaacaatgtgtgtttcagcTacaaactgggcttgactgct	10	8	1	2			TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chrX:77109426T>C	uc004fof.2	-	7	956	c.894A>G	c.(892-894)GTA>GTG	p.V298V	MAGT1_uc004fog.3_Intron	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	266					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						GTGTTTCAGCTACAAACTGGG	0.348													C	77109426	C	C	77109426	2	2	106	1	0	0	0	0	0	0	0	1	9196	1509	53	4		4	MAGT1	23	77109426	Silent	SNP	T	TCGA-06-6698-01A-11D-1845-08		77109426	78161134	51	7329											
PASD1	139135	broad.mit.edu	37	chrX	150817142	150817144	+	In_Frame_Del	DEL	GCT	-	-													aagccgtgtacgttgaacccGctgctgctgctgctgctgct							TCGA-06-6698-01A-11D-1845-08	TCGA-06-6698-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	d605a279-c0ea-467c-a423-cdf21547f87e	a2fc6ff0-c986-4828-9afa-b8917ed37851	g.chrX:150817142_150817144delGCT	uc004fev.3	+	9	1017_1019	c.685_687delGCT	c.(685-687)GCTdel	p.A236del		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	236	Poly-Ala.					nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.355													-	150817144	-	-	150817142	7	5	106	1	0	1	0	1	0	0	0	0	11471	1087	38	0	715	0	PASD1	23	150817142	In_Frame_Del	DEL	GCT	TCGA-06-6698-01A-11D-1845-08	73707716	150817142	4453418	52	7330											
CDCP2	200008	broad.mit.edu	37	chr1	54605749	54605749	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtgggctggagaagttgcccCgcatggccatgtatacctcc	13	12	0	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr1:54605749C>A	uc001cwv.1	-	4	1642	c.794G>T	c.(793-795)CGG>CTG	p.R265L		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	265	CUB 3.					extracellular region				ovary(1)	1						GAAGTTGCCCCGCATGGCCAT	0.602													A	54605749	A	A	54605749	3	1	107	1	0	0	0	0	1	0	0	0	3094	652	23	5	559	5	CDCP2	1	54605749	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08		54605749	194644872	1	7331											
GPR137B	7107	broad.mit.edu	37	chr1	236343286	236343286	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcattttctcagaacaagagCgtccattcctttgattatga	6	9	2	4			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr1:236343286C>T	uc001hxq.2	+	4	886	c.795C>T	c.(793-795)AGC>AGT	p.S265S	GPR137B_uc001hxr.1_Silent_p.S47S|GPR137B_uc009xge.2_RNA	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	265	Extracellular (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			AGAACAAGAGCGTCCATTCCT	0.473													T	236343286	T	T	236343286	2	4	107	1	0	0	0	0	0	0	0	1	6646	767	27	1		1	GPR137B	1	236343286	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08	181737537	236343286	12907335	2	7332											
IHH	3549	broad.mit.edu	37	chr2	219920384	219920384	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcgtggggggtcctgagtctCgatgacctggaaggctctca	16	10	2	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr2:219920384C>T	uc002vjo.1	-	3	781	c.781G>A	c.(781-783)GAG>AAG	p.E261K		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	261					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCTGAGTCTCGATGACCTGG	0.647													T	219920384	T	T	219920384	3	4	107	1	0	0	0	0	1	0	0	0	7607	893	31	2	458	2	IHH	2	219920384	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08		219920384	23278989	3	7333											
PCYT1A	5130	broad.mit.edu	37	chr3	195965686	195965686	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggggagggggagcgctcgCgagtagggctgctgctgggg	24	7	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr3:195965686C>T	uc003fwg.2	-	10	1150	c.977G>A	c.(976-978)CGC>CAC	p.R326H	uc003fwf.1_5'Flank|PCYT1A_uc003fwh.2_Missense_Mutation_p.R326H	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	326	3 X repeats.					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	GGAGCGCTCGCGAGTAGGGCT	0.607													T	195965686	T	T	195965686	3	4	107	1	0	0	0	0	1	0	0	0	11610	768	27	1	130	1	PCYT1A	3	195965686	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08		195965686	2056744	4	7334											
TLR10	81793	broad.mit.edu	37	chr4	38777038	38777038	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctctggagttgaaaaaggagGttataggataaatccagtgt	12	4	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr4:38777038G>T	uc003gti.2	-	2	553	c.174C>A	c.(172-174)AAC>AAA	p.N58K	TLR10_uc003gtj.2_Missense_Mutation_p.N58K|TLR10_uc003gtk.2_Missense_Mutation_p.N58K	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	58	Extracellular (Potential).|LRR 2.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						GAAAAAGGAGGTTATAGGATA	0.428													T	38777038	T	T	38777038	3	4	107	1	0	0	0	0	1	0	0	0	15947	1252	44	5	2265	5	TLR10	4	38777038	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08		38777038	152377238	5	7335											
PDS5A	23244	broad.mit.edu	37	chr4	39839671	39839671	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagattcagacttgggtcgaCgtcctctcctgggtttggaa	13	9	2	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr4:39839671C>T	uc003guv.3	-	32	4355	c.3815G>A	c.(3814-3816)CGT>CAT	p.R1272H	PDS5A_uc010ifo.2_Missense_Mutation_p.R1232H	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1272					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						CTTGGGTCGACGTCCTCTCCT	0.473													T	39839671	T	T	39839671	3	4	107	1	0	0	0	0	1	0	0	0	11691	536	19	1	206	1	PDS5A	4	39839671	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	1062633	39839671	151314605	6	7336											
DCHS2	54798	broad.mit.edu	37	chr4	155157533	155157533	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tcgttatcatccaggacactGacaaacacaactgcaaaaga	6	11	1	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr4:155157533G>A	uc003inw.2	-	25	6906	c.6906C>T	c.(6904-6906)GTC>GTT	p.V2302V		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2302	Cadherin 20.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCAGGACACTGACAAACACAA	0.373													A	155157533	A	A	155157533	2	1	107	1	0	0	0	0	0	0	0	1	4288	1277	45	3		3	DCHS2	4	155157533	Silent	SNP	G	TCGA-06-6699-01A-11D-1845-08	115317862	155157533	35996743	7	7337											
ANP32C	23520	broad.mit.edu	37	chr4	165118560	165118560	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taactgtttcagtggctctaTtgtgctgaggtctttaattt	9	6	3	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr4:165118560T>C	uc011cjk.1	-	1	304	c.304A>G	c.(304-306)ATA>GTA	p.I102V	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	102	LRR 3.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		AGTGGCTCTATTGTGCTGAGG	0.428													C	165118560	C	C	165118560	3	2	107	1	0	0	0	0	1	0	0	0	707	1493	52	4	403	4	ANP32C	4	165118560	Missense_Mutation	SNP	T	TCGA-06-6699-01A-11D-1845-08	9961027	165118560	26035716	8	7338											
PLEKHG4B	153478	broad.mit.edu	37	chr5	162950	162950	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggctgcagaggccttcccCggggcaggtgtggcagtgct	18	11	0	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr5:162950C>T	uc003jak.2	+	11	1745	c.1695C>T	c.(1693-1695)CCC>CCT	p.P565P		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	565					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGGCCTTCCCCGGGGCAGGTG	0.667													T	162950	T	T	162950	2	4	107	1	0	0	0	0	0	0	0	1	12072	639	23	2		2	PLEKHG4B	5	162950	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08		162950	180752310	9	7339											
KLHL3	26249	broad.mit.edu	37	chr5	137045486	137045486	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaggctgccaggaccacaCggtgggcttctatctcgaca	12	13	2	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr5:137045486C>T	uc010jek.2	-	3	638	c.194G>A	c.(193-195)CGT>CAT	p.R65H	MYOT_uc011cye.1_Intron|KLHL3_uc010jem.1_Missense_Mutation_p.R25H	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	65	BTB.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		CAGGACCACACGGTGGGCTTC	0.547													T	137045486	T	T	137045486	3	4	107	1	0	0	0	0	1	0	0	0	8383	536	19	1	1621	1	KLHL3	5	137045486	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	136882536	137045486	43869774	10	7340											
PCDHA4	56144	broad.mit.edu	37	chr5	140188686	140188686	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcacaacgcgtgccctggaCgaaacggacgctccgcgcca	12	16	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr5:140188686C>T	uc003lhi.2	+	1	2015	c.1914C>T	c.(1912-1914)GAC>GAT	p.D638D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.D638D|PCDHA4_uc011daa.1_Silent_p.D638D	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	638	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCCCTGGACGAAACGGACG	0.677													T	140188686	T	T	140188686	2	4	107	1	0	0	0	0	0	0	0	1	11526	535	19	1		1	PCDHA4	5	140188686	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08	3143200	140188686	40726574	11	7341											
PCDHGA4	56111	broad.mit.edu	37	chr5	140736994	140736994	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcctcgcactttgtgggcGtggacggggttcgggctttc	16	11	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr5:140736994G>A	uc003ljq.1	+	1	2227	c.2227G>A	c.(2227-2229)GTG>ATG	p.V743M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGB2_uc003ljs.1_5'Flank|PCDHGA4_uc003ljp.1_Missense_Mutation_p.V743M|PCDHGB2_uc011dar.1_5'Flank	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	743	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTTGTGGGCGTGGACGGGGT	0.617													A	140736994	A	A	140736994	3	1	107	1	0	0	0	0	1	0	0	0	11556	1145	40	1	2229	1	PCDHGA4	5	140736994	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	548308	140736994	40178266	12	7342											
SYNGAP1	8831	broad.mit.edu	37	chr6	33405652	33405652	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccggctgtccgtgccctgCggctgcatctgtaccgtgac	13	15	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr6:33405652C>T	uc011dri.1	+	8	1165	c.970C>T	c.(970-972)CGG>TGG	p.R324W	SYNGAP1_uc003oeo.1_Missense_Mutation_p.R309W|SYNGAP1_uc010juy.2_Missense_Mutation_p.R309W|SYNGAP1_uc010juz.2_Missense_Mutation_p.R36W	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	324	C2.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CCGTGCCCTGCGGCTGCATCT	0.627													T	33405652	T	T	33405652	3	4	107	1	0	0	0	0	1	0	0	0	15444	759	27	1	1000	1	SYNGAP1	6	33405652	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08		33405652	137709415	13	7343											
ABCC10	89845	broad.mit.edu	37	chr6	43403588	43403588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggccaaagtgtccttggacCggatccagcttttcctcgac	10	13	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr6:43403588C>T	uc003ouy.1	+	5	1923	c.1708C>T	c.(1708-1710)CGG>TGG	p.R570W	ABCC10_uc003ouz.1_Missense_Mutation_p.R527W|ABCC10_uc010jyo.1_5'UTR	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	570						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GTCCTTGGACCGGATCCAGCT	0.567													T	43403588	T	T	43403588	3	4	107	1	0	0	0	0	1	0	0	0	50	643	23	2	1589	2	ABCC10	6	43403588	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	9997936	43403588	127711479	14	7344											
TFAP2D	83741	broad.mit.edu	37	chr6	50696975	50696975	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttggcttaaacttaccagCaggaagacggaaagcagcta	11	9	0	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr6:50696975C>T	uc003paf.2	+	5	1345	c.833C>T	c.(832-834)GCA>GTA	p.A278V	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	278							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					AACTTACCAGCAGGAAGACGG	0.423													T	50696975	T	T	50696975	3	4	107	1	0	0	0	0	1	0	0	0	15787	710	25	3	851	3	TFAP2D	6	50696975	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	7293387	50696975	120418092	15	7345											
SIM1	6492	broad.mit.edu	37	chr6	100901684	100901684	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccaacgttgtccagggggCtggtccgacttgagtggccc	16	12	0	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr6:100901684C>T	uc003pqj.3	-	2	419	c.212G>A	c.(211-213)AGC>AAC	p.S71N	SIM1_uc010kcu.2_Missense_Mutation_p.S71N	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	71					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GTCCAGGGGGCTGGTCCGACT	0.612													T	100901684	T	T	100901684	3	4	107	1	0	0	0	0	1	0	0	0	14323	797	28	3	2128	3	SIM1	6	100901684	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	50204709	100901684	70213383	16	7346											
ZBTB24	9841	broad.mit.edu	37	chr6	109787239	109787239	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccttggacagagtgatcaCgtgcactggctctgtttgtg	12	9	2	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr6:109787239C>T	uc003ptl.1	-	7	2077	c.1909G>A	c.(1909-1911)GTG>ATG	p.V637M	MICAL1_uc011eaq.1_5'Flank|ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.V581M|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	637					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		AGAGTGATCACGTGCACTGGC	0.458													T	109787239	T	T	109787239	3	4	107	1	0	0	0	0	1	0	0	0	17528	536	19	1	188	1	ZBTB24	6	109787239	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	8885555	109787239	61327828	17	7347											
PARK2	5071	broad.mit.edu	37	chr6	161771139	161771139	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cggccgccctggctacacgtCgaaccagtggtcccccatgc	11	18	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr6:161771139C>T	uc003qtx.3	-	12	1524	c.1390G>A	c.(1390-1392)GAC>AAC	p.D464N	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Missense_Mutation_p.D273N|PARK2_uc003qtw.3_3'UTR|PARK2_uc003qty.3_Missense_Mutation_p.D436N|PARK2_uc003qtz.3_Missense_Mutation_p.D315N|PARK2_uc011egf.1_Missense_Mutation_p.D138N	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	464					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		GGCTACACGTCGAACCAGTGG	0.567													T	161771139	T	T	161771139	3	4	107	1	0	0	0	0	1	0	0	0	11449	884	31	2	11	2	PARK2	6	161771139	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	51983900	161771139	9343928	18	7348											
PMS2	5395	broad.mit.edu	37	chr7	6027045	6027045	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctagaagacagcataccccTtttctgtcctagagggctcc	9	13	1	3			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr7:6027045T>C	uc003spl.2	-	11	1438	c.1351A>G	c.(1351-1353)AGG>GGG	p.R451G	PMS2_uc003spj.2_Missense_Mutation_p.R345G|PMS2_uc003spk.2_Missense_Mutation_p.R316G|PMS2_uc011jwl.1_Missense_Mutation_p.R316G|PMS2_uc010ktg.2_Missense_Mutation_p.R140G|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Missense_Mutation_p.R451G	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	451					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		AGCATACCCCTTTTCTGTCCT	0.532			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				C	6027045	C	C	6027045	3	2	107	1	0	0	0	0	1	0	0	0	12143	1608	56	4	1257	4	PMS2	7	6027045	Missense_Mutation	SNP	T	TCGA-06-6699-01A-11D-1845-08		6027045	153111618	19	7349											
MLXIPL	51085	broad.mit.edu	37	chr7	73010591	73010591	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcggagatgtgtgtgatacgCcggttctcggtctcggggag	18	8	2	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr7:73010591C>A	uc003tyn.1	-	13	1998	c.1950G>T	c.(1948-1950)CGG>CGT	p.R650R	MLXIPL_uc003tyj.1_Silent_p.R29R|MLXIPL_uc003tyk.1_Silent_p.R648R|MLXIPL_uc003tyl.1_Silent_p.R648R|MLXIPL_uc003tym.1_Silent_p.R650R|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Silent_p.R556R	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	650	Basic motif.				anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				GTGTGATACGCCGGTTCTCGG	0.627													A	73010591	A	A	73010591	2	1	107	1	0	0	0	0	0	0	0	1	9637	726	26	5		5	MLXIPL	7	73010591	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08	66983546	73010591	86128072	20	7350											
PCLO	27445	broad.mit.edu	37	chr7	82595385	82595385	+	Frame_Shift_Del	DEL	T	-	-													ttttgtcttcaggggttggcTttttttcttctaggagtggc							TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr7:82595385delT	uc003uhx.2	-	4	4008	c.3719delA	c.(3718-3720)AAGfs	p.K1240fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.K1240fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1179					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGGGGTTGGCTTTTTTTCTTC	0.383													-	82595385	-	-	82595385	7	5	107	1	0	1	0	1	0	0	0	0	11583	1609	56	0	11814	0	PCLO	7	82595385	Frame_Shift_Del	DEL	T	TCGA-06-6699-01A-11D-1845-08	9584794	82595385	76543278	21	7351											
SEMA3E	9723	broad.mit.edu	37	chr7	83047753	83047753	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggggtcaaaaggacatctgCcccttcctctctcagatctg	9	13	5	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr7:83047753C>T	uc003uhy.1	-	5	969	c.503G>A	c.(502-504)GGC>GAC	p.G168D		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	168	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				AGGACATCTGCCCCTTCCTCT	0.403													T	83047753	T	T	83047753	3	4	107	1	0	0	0	0	1	0	0	0	14028	739	26	3	1876	3	SEMA3E	7	83047753	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	452368	83047753	76090910	22	7352											
SLC26A5	375611	broad.mit.edu	37	chr7	103032068	103032068	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaggcctgttatgtacataCctgtgtcttcccaccggttc	9	12	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr7:103032068C>T	uc003vbz.2	-	11	1469	c.1233_splice	c.e11+1	p.Q411_splice	SLC26A5_uc003vbt.1_Splice_Site_p.Q411_splice|SLC26A5_uc003vbu.1_Splice_Site_p.Q411_splice|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_Splice_Site|SLC26A5_uc003vbx.2_Splice_Site_p.Q411_splice|SLC26A5_uc003vby.2_Splice_Site|SLC26A5_uc010liy.2_Splice_Site	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a						regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TATGTACATACCTGTGTCTTC	0.438													T	103032068	T	T	103032068	5	4	107	1	0	0	0	0	0	0	1	0	14520	521	18	3	1081	3	SLC26A5	7	103032068	Splice_Site	SNP	C	TCGA-06-6699-01A-11D-1845-08	19984315	103032068	56106595	23	7353											
C7orf66	154907	broad.mit.edu	37	chr7	108524200	108524200	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctctgatccatcatgtgaCgatattgagctgagaattcc	8	9	2	4			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr7:108524200C>T	uc003vfo.2	-	2	260	c.212G>A	c.(211-213)CGT>CAT	p.R71H		NM_001024607	NP_001019778	A4D0T2	CG066_HUMAN	hypothetical protein LOC154907	71						integral to membrane				ovary(2)	2						CATCATGTGACGATATTGAGC	0.418													T	108524200	T	T	108524200	3	4	107	1	0	0	0	0	1	0	0	0	2412	536	19	1	139	1	C7orf66	7	108524200	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	5492132	108524200	50614463	24	7354											
LMBR1	64327	broad.mit.edu	37	chr7	156518202	156518202	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ggctatagaagccgacaacaGaggacaccataagatagctg	11	9	0	3			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr7:156518202G>T	uc003wmw.3	-	14	1300	c.1085C>A	c.(1084-1086)TCT>TAT	p.S362Y	LMBR1_uc003wmv.3_Missense_Mutation_p.S210Y|LMBR1_uc003wmx.3_Missense_Mutation_p.S210Y|LMBR1_uc010lqn.2_Missense_Mutation_p.S403Y|LMBR1_uc011kvx.1_Missense_Mutation_p.S341Y	NM_022458	NP_071903	Q8WVP7	LMBR1_HUMAN	limb region 1 protein	362	Cytoplasmic (Potential).					integral to membrane	receptor activity				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		GCCGACAACAGAGGACACCAT	0.413													T	156518202	T	T	156518202	3	4	107	1	0	0	0	0	1	0	0	0	8840	942	33	5	403	5	LMBR1	7	156518202	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	47994002	156518202	2620461	25	7355											
PTPRN2	5799	broad.mit.edu	37	chr7	157475460	157475460	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacctgggtcgccccctagtCccgagagcttctccttcagc	9	18	2	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr7:157475460C>T	uc003wno.2	-	13	2079	c.1958G>A	c.(1957-1959)GGA>GAA	p.G653E	PTPRN2_uc003wnp.2_Missense_Mutation_p.G636E|PTPRN2_uc003wnq.2_Missense_Mutation_p.G624E|PTPRN2_uc003wnr.2_Missense_Mutation_p.G615E|PTPRN2_uc011kwa.1_Missense_Mutation_p.G676E	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	653	Cytoplasmic (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GCCCCCTAGTCCCGAGAGCTT	0.567													T	157475460	T	T	157475460	3	4	107	1	0	0	0	0	1	0	0	0	12808	855	30	3	1133	3	PTPRN2	7	157475460	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	957258	157475460	1663203	26	7356											
PRSS55	203074	broad.mit.edu	37	chr8	10396129	10396129	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtgaactacaacctctggatCgagaaagtgacccagctaga	10	10	1	4			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr8:10396129C>T	uc003wta.2	+	5	900	c.885C>T	c.(883-885)ATC>ATT	p.I295I	uc010lru.2_Intron|PRSS55_uc003wtb.2_Intron	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	295	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						ACCTCTGGATCGAGAAAGTGA	0.532													T	10396129	T	T	10396129	2	4	107	1	0	0	0	0	0	0	0	1	12634	874	31	2		2	PRSS55	8	10396129	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08		10396129	135967893	27	7357											
CPA6	57094	broad.mit.edu	37	chr8	68396059	68396059	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctccacggcagcgaaaccttGagttccttgaccttgttttt	8	12	0	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr8:68396059G>A	uc003xxq.3	-	8	1038	c.782C>T	c.(781-783)TCA>TTA	p.S261L	CPA6_uc003xxr.3_Missense_Mutation_p.S113L|CPA6_uc003xxs.2_Missense_Mutation_p.S261L	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	261					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			GCGAAACCTTGAGTTCCTTGA	0.408													A	68396059	A	A	68396059	3	1	107	1	0	0	0	0	1	0	0	0	3794	1294	45	3	547	3	CPA6	8	68396059	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	57999930	68396059	77967963	28	7358											
FER1L6	654463	broad.mit.edu	37	chr8	125131850	125131850	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcttccttccccctcagccGcccagacacctccttttcgt	4	21	2	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr8:125131850G>A	uc003yqw.2	+	41	5599	c.5393G>A	c.(5392-5394)CGC>CAC	p.R1798H	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1798	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCCCTCAGCCGCCCAGACACC	0.433													A	125131850	A	A	125131850	3	1	107	1	0	0	0	0	1	0	0	0	5815	1087	38	1	5551	1	FER1L6	8	125131850	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	56735791	125131850	21232172	29	7359											
TG	7038	broad.mit.edu	37	chr8	133879248	133879248	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggaagggccaggaaaatGgccctggtcctggagatctt	14	10	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr8:133879248G>A	uc003ytw.2	+	1	44	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCAGGAAAATGGCCCTGGTCC	0.592													A	133879248	A	A	133879248	3	1	107	1	0	0	0	0	1	0	0	0	15810	1348	47	3	5	3	TG	8	133879248	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	8747398	133879248	12484774	30	7360											
PTPDC1	138639	broad.mit.edu	37	chr9	96860365	96860365	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggaagccttggttcgcagcaCactttctttctggagtcagt	11	10	3	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr9:96860365C>A	uc004auf.1	+	7	1695	c.1355C>A	c.(1354-1356)ACA>AAA	p.T452K	PTPDC1_uc004aug.1_Missense_Mutation_p.T452K|PTPDC1_uc004auh.1_Missense_Mutation_p.T504K|PTPDC1_uc010mrj.1_Missense_Mutation_p.T506K|PTPDC1_uc010mri.1_Missense_Mutation_p.T504K	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	452							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						GTTCGCAGCACACTTTCTTTC	0.483													A	96860365	A	A	96860365	3	1	107	1	0	0	0	0	1	0	0	0	12773	478	17	5	1619	5	PTPDC1	9	96860365	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08		96860365	44353066	31	7361											
DTX4	23220	broad.mit.edu	37	chr11	58949764	58949764	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccactgaagaccgccccatCgcaggtgatccggagacaag	11	15	0	4			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr11:58949764C>T	uc001nns.2	+	2	1021	c.764C>T	c.(763-765)TCG>TTG	p.S255L	DTX4_uc001nnr.2_Missense_Mutation_p.S149L	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	255					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				ACCGCCCCATCGCAGGTGATC	0.657													T	58949764	T	T	58949764	3	4	107	1	0	0	0	0	1	0	0	0	4797	893	31	2	770	2	DTX4	11	58949764	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08		58949764	76056752	32	7362											
MMP13	4322	broad.mit.edu	37	chr11	102826186	102826186	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attctccttcaggattcccgCgagatttgtaggatggtagt	11	8	2	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr11:102826186C>T	uc001phl.2	-	2	185	c.157G>A	c.(157-159)GCG>ACG	p.A53T		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	53					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		AGGATTCCCGCGAGATTTGTA	0.458													T	102826186	T	T	102826186	3	4	107	1	0	0	0	0	1	0	0	0	9652	768	27	1	1294	1	MMP13	11	102826186	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	43876422	102826186	32180330	33	7363											
IL23A	51561	broad.mit.edu	37	chr12	56733735	56733735	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgtcctttcagcctgagggTcaccactgggagactcagca	11	12	3	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr12:56733735T>C	uc001sla.2	+	4	583	c.417T>C	c.(415-417)GGT>GGC	p.G139G		NM_016584	NP_057668	Q9NPF7	IL23A_HUMAN	interleukin 23, alpha subunit p19 precursor	139					defense response to Gram-negative bacterium|inflammatory response|innate immune response|negative regulation of interleukin-10 production|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to virus|tissue remodeling	interleukin-23 complex	cytokine activity				0						AGCCTGAGGGTCACCACTGGG	0.572													C	56733735	C	C	56733735	2	2	107	1	0	0	0	0	0	0	0	1	7675	1654	58	4		4	IL23A	12	56733735	Silent	SNP	T	TCGA-06-6699-01A-11D-1845-08		56733735	77118160	34	7364											
CUX2	23316	broad.mit.edu	37	chr12	111785603	111785603	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatgctgaggaagaggcagGcagccagccccaggactcag	16	11	1	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr12:111785603G>A	uc001tsa.1	+	22	4088	c.3935G>A	c.(3934-3936)GGC>GAC	p.G1312D		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1312						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GAAGAGGCAGGCAGCCAGCCC	0.612													A	111785603	A	A	111785603	3	1	107	1	0	0	0	0	1	0	0	0	4065	1203	42	3	4021	3	CUX2	12	111785603	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	55051868	111785603	22066292	35	7365											
FAM124A	220108	broad.mit.edu	37	chr13	51825704	51825704	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcaggaggccatcgacaaCgtcctggcgtggatccaccc	12	15	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr13:51825704C>T	uc001vfg.1	+	3	332	c.201C>T	c.(199-201)AAC>AAT	p.N67N	FAM124A_uc001vfe.2_Silent_p.N67N|FAM124A_uc001vff.1_Silent_p.N103N	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	67										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		CCATCGACAACGTCCTGGCGT	0.687													T	51825704	T	T	51825704	2	4	107	1	0	0	0	0	0	0	0	1	5425	535	19	1		1	FAM124A	13	51825704	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08		51825704	63344174	36	7366											
MAX	4149	broad.mit.edu	37	chr14	65569050	65569050	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccacctcgatgtcatcgttaTcgctcatttcctacggccca	6	16	2	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr14:65569050T>A	uc001xif.1	-	1	178	c.8A>T	c.(7-9)GAT>GTT	p.D3V	MAX_uc001xic.1_Missense_Mutation_p.D3V|MAX_uc001xie.1_Missense_Mutation_p.D3V|MAX_uc010aql.1_Missense_Mutation_p.D3V|MAX_uc001xig.1_Missense_Mutation_p.D3V|MAX_uc001xih.1_RNA|MAX_uc001xii.1_Missense_Mutation_p.D3V|MAX_uc001xij.1_Missense_Mutation_p.D3V|MAX_uc001xik.2_Missense_Mutation_p.D3V	NM_002382	NP_002373	P61244	MAX_HUMAN	MAX protein isoform a	3					transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GTCATCGTTATCGCTCATTTC	0.552													A	65569050	A	A	65569050	3	1	107	1	0	0	0	0	1	0	0	0	9339	1435	50	5	834	5	MAX	14	65569050	Missense_Mutation	SNP	T	TCGA-06-6699-01A-11D-1845-08		65569050	41780490	37	7367											
ISM2	145501	broad.mit.edu	37	chr14	77942269	77942269	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtagatgtccaggcgctcgCgagggccactggcatccctc	14	14	0	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr14:77942269C>T	uc001xtz.2	-	7	1459	c.1385G>A	c.(1384-1386)CGC>CAC	p.R462H	ISM2_uc001xua.2_3'UTR|ISM2_uc001xty.2_Missense_Mutation_p.R374H|ISM2_uc010tvl.1_Missense_Mutation_p.R381H	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	462	AMOP.					extracellular region				skin(1)	1						CAGGCGCTCGCGAGGGCCACT	0.672													T	77942269	T	T	77942269	3	4	107	1	0	0	0	0	1	0	0	0	7861	768	27	1	334	1	ISM2	14	77942269	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	12373219	77942269	29407271	38	7368											
ATG2B	55102	broad.mit.edu	37	chr14	96752258	96752258	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctcgcccacggcaccagtcAcccctctgctctcgtgttct	7	20	4	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr14:96752258A>C	uc001yfi.2	-	42	6436	c.6071T>G	c.(6070-6072)GTG>GGG	p.V2024G		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	2024										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GGCACCAGTCACCCCTCTGCT	0.582													C	96752258	C	C	96752258	3	2	107	1	0	0	0	0	1	0	0	0	1094	159	6	5	169	5	ATG2B	14	96752258	Missense_Mutation	SNP	A	TCGA-06-6699-01A-11D-1845-08	18809989	96752258	10597282	39	7369											
C15orf2	23742	broad.mit.edu	37	chr15	24921107	24921107	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgctcccctgtcccgggaCgcctccccgcccggtcgggc	12	23	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr15:24921107C>T	uc001ywo.2	+	1	567	c.93C>T	c.(91-93)GAC>GAT	p.D31D		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	31					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TGTCCCGGGACGCCTCCCCGC	0.697													T	24921107	T	T	24921107	2	4	107	1	0	0	0	0	0	0	0	1	1784	535	19	1		1	C15orf2	15	24921107	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08		24921107	77610285	40	7370											
OCA2	4948	broad.mit.edu	37	chr15	28273201	28273201	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggtaaacaggtatgcaccGtgacctggaaagcaagagag	13	7	0	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr15:28273201G>A	uc001zbh.3	-	4	441	c.331C>T	c.(331-333)CGG>TGG	p.R111W	OCA2_uc010ayv.2_Missense_Mutation_p.R111W	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	111	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GGTATGCACCGTGACCTGGAA	0.488									Oculocutaneous_Albinism				A	28273201	A	A	28273201	3	1	107	1	0	0	0	0	1	0	0	0	10815	1144	40	1	2269	1	OCA2	15	28273201	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	3352094	28273201	74258191	41	7371											
WDR76	79968	broad.mit.edu	37	chr15	44150913	44150913	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgattgaattccaggagaaGtcagcctttgatttctttga	10	7	2	4			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr15:44150913G>A	uc001zti.1	+	11	1477	c.1454G>A	c.(1453-1455)AGT>AAT	p.S485N		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	485	WD 4.										0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		TCCAGGAGAAGTCAGCCTTTG	0.403													A	44150913	A	A	44150913	3	1	107	1	0	0	0	0	1	0	0	0	17323	1029	36	3	1496	3	WDR76	15	44150913	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	15877712	44150913	58380479	42	7372											
ADAMTS7	11173	broad.mit.edu	37	chr15	79067005	79067005	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatgtgtgcagctggccctTgtagagcatagcgtcaaagt	12	10	1	1	rs151217691		TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr15:79067005T>C	uc002bej.3	-	12	2048	c.1837A>G	c.(1837-1839)AAG>GAG	p.K613E	ADAMTS7_uc010und.1_Intron|ADAMTS7_uc002bek.1_Missense_Mutation_p.K613E	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	613	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						AGCTGGCCCTTGTAGAGCATA	0.642													C	79067005	C	C	79067005	3	2	107	1	0	0	0	0	1	0	0	0	271	1821	63	4	3275	4	ADAMTS7	15	79067005	Missense_Mutation	SNP	T	TCGA-06-6699-01A-11D-1845-08	34916092	79067005	23464387	43	7373											
SSTR5	6755	broad.mit.edu	37	chr16	1129345	1129345	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgcgtgtggccaagctggcGagcgccgcggcctgggtcct	17	15	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr16:1129345G>A	uc002ckq.2	+	1	565	c.477G>A	c.(475-477)GCG>GCA	p.A159A	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	159	Helical; Name=4; (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	CCAAGCTGGCGAGCGCCGCGG	0.706													A	1129345	A	A	1129345	2	1	107	1	0	0	0	0	0	0	0	1	15200	1045	37	2		2	SSTR5	16	1129345	Silent	SNP	G	TCGA-06-6699-01A-11D-1845-08		1129345	89225408	44	7374											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1814345	1814345	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctgagcgggtggaggcccaAtgaggacgacgctgggaatg	18	9	0	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr16:1814345A>G	uc002cmk.2	+	19	2282	c.2162A>G	c.(2161-2163)AAT>AGT	p.N721S	MAPK8IP3_uc002cml.2_Missense_Mutation_p.N715S|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.N722S	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	721					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						TGGAGGCCCAATGAGGACGAC	0.706													G	1814345	G	G	1814345	3	3	107	1	0	0	0	0	1	0	0	0	9286	101	4	4	2252	4	MAPK8IP3	16	1814345	Missense_Mutation	SNP	A	TCGA-06-6699-01A-11D-1845-08	685000	1814345	88540408	45	7375											
ADAMTS18	170692	broad.mit.edu	37	chr16	77356301	77356301	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttccatctttcactttgcCggacattgcaaaaaaaaatt	5	9	2	0	rs142855321		TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr16:77356301C>T	uc002ffc.3	-	14	2514	c.2095G>A	c.(2095-2097)GGC>AGC	p.G699S	ADAMTS18_uc010chc.1_Missense_Mutation_p.G287S|ADAMTS18_uc002ffe.1_Missense_Mutation_p.G395S	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	699	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TTCACTTTGCCGGACATTGCA	0.403													T	77356301	T	T	77356301	3	4	107	1	0	0	0	0	1	0	0	0	263	652	23	2	1610	2	ADAMTS18	16	77356301	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	75541956	77356301	12998452	46	7376											
MYO15A	51168	broad.mit.edu	37	chr17	18022706	18022706	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgcagccgcagcatctacGcgtcaggcgagcccctgggc	13	18	2	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr17:18022706G>A	uc010vxh.1	+	2	930	c.592G>A	c.(592-594)GCG>ACG	p.A198T		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	198	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CAGCATCTACGCGTCAGGCGA	0.701													A	18022706	A	A	18022706	3	1	107	1	0	0	0	0	1	0	0	0	10063	1087	38	1	594	1	MYO15A	17	18022706	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08		18022706	63172504	47	7377											
FAM83G	644815	broad.mit.edu	37	chr17	18891569	18891569	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcctgctcaccttgaggtgCcccaggtgcatgcaggcccg	13	15	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr17:18891569C>T	uc002guw.2	-	3	848	c.681G>A	c.(679-681)GGG>GGA	p.G227G	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	227										ovary(1)|central_nervous_system(1)	2						CCTTGAGGTGCCCCAGGTGCA	0.463													T	18891569	T	T	18891569	2	4	107	1	0	0	0	0	0	0	0	1	5639	726	26	3		3	FAM83G	17	18891569	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08	868863	18891569	62303641	48	7378											
ACE	1636	broad.mit.edu	37	chr17	61560507	61560507	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggcgtacccccccttcccGctacaacttcgactggtggt	10	16	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr17:61560507G>A	uc002jau.1	+	9	1482	c.1460G>A	c.(1459-1461)CGC>CAC	p.R487H	ACE_uc010wpi.1_Intron|ACE_uc010ddu.1_Missense_Mutation_p.R304H|ACE_uc002jav.1_5'Flank|ACE_uc010ddv.1_5'Flank|ACE_uc010wpj.1_5'Flank|ACE_uc002jaw.1_5'Flank|ACE_uc010wpk.1_5'Flank	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	487	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CCCCCTTCCCGCTACAACTTC	0.587													A	61560507	A	A	61560507	3	1	107	1	0	0	0	0	1	0	0	0	136	1087	38	1	1494	1	ACE	17	61560507	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	42668938	61560507	19634703	49	7379											
SOX9	6662	broad.mit.edu	37	chr17	70117873	70117873	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcccatgaacgccttcatggTgtgggcgcaggcggcgcgca	16	13	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr17:70117873T>C	uc002jiw.2	+	1	713	c.341T>C	c.(340-342)GTG>GCG	p.V114A	uc002jiv.2_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	114	HMG box.				cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			GCCTTCATGGTGTGGGCGCAG	0.657													C	70117873	C	C	70117873	3	2	107	1	0	0	0	0	1	0	0	0	14958	1696	59	4	343	4	SOX9	17	70117873	Missense_Mutation	SNP	T	TCGA-06-6699-01A-11D-1845-08	8557366	70117873	11077337	50	7380											
CSNK1D	1453	broad.mit.edu	37	chr17	80213441	80213441	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgccccgcaccatctgatgGtggggatgcccactaggcaa	12	14	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr17:80213441G>A	uc002kej.2	-	3	516	c.200C>T	c.(199-201)ACC>ATC	p.T67I	SLC16A3_uc002kee.2_Intron|CSNK1D_uc002kef.2_Missense_Mutation_p.T67I|CSNK1D_uc002kei.2_Missense_Mutation_p.T67I|CSNK1D_uc010wvj.1_5'UTR|CSNK1D_uc002keh.2_5'Flank|CSNK1D_uc010dim.1_5'Flank	NM_001893	NP_001884	P48730	KC1D_HUMAN	casein kinase 1, delta isoform 1	67	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)	2	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			CCATCTGATGGTGGGGATGCC	0.572													A	80213441	A	A	80213441	3	1	107	1	0	0	0	0	1	0	0	0	3952	1261	44	3	1112	3	CSNK1D	17	80213441	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	10095568	80213441	981769	51	7381											
ANKRD30B	374860	broad.mit.edu	37	chr18	14803789	14803789	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttacccaaggctacacatcaAaaagaattcgataccttaag	5	10	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr18:14803789A>G	uc010dlo.2	+	24	2430	c.2250A>G	c.(2248-2250)CAA>CAG	p.Q750Q	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	835										ovary(1)|skin(1)	2						CTACACATCAAAAAGAATTCG	0.323													G	14803789	G	G	14803789	2	3	107	1	0	0	0	0	0	0	0	1	659	11	1	4		4	ANKRD30B	18	14803789	Silent	SNP	A	TCGA-06-6699-01A-11D-1845-08		14803789	63273459	52	7382											
RBBP8	5932	broad.mit.edu	37	chr18	20572852	20572853	+	Frame_Shift_Ins	INS	-	A	A													cttctcttttacagcctgggINSaaaaaaaaacatctgaaaac							TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr18:20572852_20572853insA	uc002ktw.2	+	11	1393_1394	c.1062_1063insA	c.(1060-1065)GGGAAAfs	p.G354fs	RBBP8_uc002kty.2_Frame_Shift_Ins_p.G354fs|RBBP8_uc002ktz.2_Frame_Shift_Ins_p.G354fs|RBBP8_uc002kua.2_Frame_Shift_Ins_p.G354fs|RBBP8_uc002ktx.1_Frame_Shift_Ins_p.G354fs	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	354_355					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			TACAGCCTGGGAAAAAAAAACA	0.361								Direct_reversal_of_damage|Homologous_recombination					A	20572853	A	A	20572852	7	5	107	1	0	1	1	0	0	0	0	0	13105	1161	41	0	1100	0	RBBP8	18	20572852	Frame_Shift_Ins	INS	-	TCGA-06-6699-01A-11D-1845-08	5769063	20572852	57504396	53	7383											
PIGN	23556	broad.mit.edu	37	chr18	59757728	59757728	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttttgtttacagcaaacaCcagattgttgtagagtttct	7	8	1	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr18:59757728C>T	uc002lii.3	-	25	2712	c.2264G>A	c.(2263-2265)GGT>GAT	p.G755D	PIGN_uc002lij.3_Missense_Mutation_p.G755D	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	755	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				ACAGCAAACACCAGATTGTTG	0.343													T	59757728	T	T	59757728	3	4	107	1	0	0	0	0	1	0	0	0	11893	507	18	3	563	3	PIGN	18	59757728	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	39184876	59757728	18319520	54	7384											
KCNG2	26251	broad.mit.edu	37	chr18	77623839	77623839	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacgacgacctgctgcgcGtgtgtgacgactacgacgtg	14	13	0	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr18:77623839G>A	uc010xfl.1	+	1	172	c.172G>A	c.(172-174)GTG>ATG	p.V58M		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	58	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CCTGCTGCGCGTGTGTGACGA	0.741													A	77623839	A	A	77623839	3	1	107	1	0	0	0	0	1	0	0	0	8028	1145	40	1	174	1	KCNG2	18	77623839	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	17866111	77623839	453409	55	7385											
C19orf35	374872	broad.mit.edu	37	chr19	2278816	2278816	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agcctccgggctgtgcagatCgcggagggagaggcccagtg	18	11	0	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr19:2278816C>A	uc002lvn.2	-	3	479	c.379G>T	c.(379-381)GAT>TAT	p.D127Y	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	127										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGTGCAGATCGCGGAGGGAG	0.692													A	2278816	A	A	2278816	3	1	107	1	0	0	0	0	1	0	0	0	1920	884	31	5	1050	5	C19orf35	19	2278816	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08		2278816	56850167	56	7386											
CLEC4M	10332	broad.mit.edu	37	chr19	7833851	7833851	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggatctgcaaaaagcccGcagcctgcttcagagacgaa	10	12	2	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr19:7833851G>A	uc002mih.2	+	8	1226	c.1108G>A	c.(1108-1110)GCA>ACA	p.A370T	CLEC4M_uc010xjw.1_Missense_Mutation_p.A326T|CLEC4M_uc010dvt.2_Missense_Mutation_p.A347T|CLEC4M_uc010dvs.2_Missense_Mutation_p.A369T|CLEC4M_uc010xjx.1_Missense_Mutation_p.A342T|CLEC4M_uc002mhz.2_3'UTR|CLEC4M_uc002mic.2_3'UTR|CLEC4M_uc002mia.2_Missense_Mutation_p.A257T	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	393	Extracellular (Probable).				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						CAAAAAGCCCGCAGCCTGCTT	0.498													A	7833851	A	A	7833851	3	1	107	1	0	0	0	0	1	0	0	0	3518	1087	38	1	1224	1	CLEC4M	19	7833851	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	5555035	7833851	51295132	57	7387											
FBN3	84467	broad.mit.edu	37	chr19	8148157	8148157	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggtagtagcagtagcatccGgtgtgtacccggcctgacag	14	10	0	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr19:8148157G>T	uc002mjf.2	-	56	7208	c.7187C>A	c.(7186-7188)CCG>CAG	p.P2396Q	FBN3_uc002mje.2_Missense_Mutation_p.P235Q	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2396	EGF-like 38; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AGTAGCATCCGGTGTGTACCC	0.602													T	8148157	T	T	8148157	3	4	107	1	0	0	0	0	1	0	0	0	5704	1116	39	5	1274	5	FBN3	19	8148157	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	314306	8148157	50980826	58	7388											
MUC16	94025	broad.mit.edu	37	chr19	9056233	9056233	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcactgttcccagctcaaCgctctctgtcattctggtat	7	13	5	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr19:9056233C>T	uc002mkp.2	-	3	31417	c.31213G>A	c.(31213-31215)GTT>ATT	p.V10405I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10407	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCCAGCTCAACGCTCTCTGTC	0.483													T	9056233	T	T	9056233	3	4	107	1	0	0	0	0	1	0	0	0	9973	536	19	1	12638	1	MUC16	19	9056233	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	908076	9056233	50072750	59	7389											
OLFM2	93145	broad.mit.edu	37	chr19	9965148	9965148	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggggtagccggtgtcccagGaccgcatgacctcgagggtg	17	11	0	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr19:9965148G>A	uc002mmp.2	-	6	1107	c.1079C>T	c.(1078-1080)TCC>TTC	p.S360F	OLFM2_uc002mmo.2_Missense_Mutation_p.S282F	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	360	Olfactomedin-like.					extracellular region				large_intestine(1)|skin(1)	2						GGTGTCCCAGGACCGCATGAC	0.657													A	9965148	A	A	9965148	3	1	107	1	0	0	0	0	1	0	0	0	10853	1174	41	3	289	3	OLFM2	19	9965148	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	908915	9965148	49163835	60	7390											
CYP4F11	57834	broad.mit.edu	37	chr19	16025652	16025652	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgggactgggggatgcaacCgcaggctctccttaatgcac	13	13	1	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr19:16025652C>T	uc002nbu.2	-	10	1205	c.1169G>A	c.(1168-1170)CGG>CAG	p.R390Q	CYP4F11_uc010eab.1_Missense_Mutation_p.R390Q|CYP4F11_uc002nbt.2_Missense_Mutation_p.R390Q	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	390					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						GGGATGCAACCGCAGGCTCTC	0.592													T	16025652	T	T	16025652	3	4	107	1	0	0	0	0	1	0	0	0	4186	652	23	2	421	2	CYP4F11	19	16025652	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	6060504	16025652	43103331	61	7391											
ZNF302	55900	broad.mit.edu	37	chr19	35175342	35175342	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cctttcattcaaagtctactCtttctgaaccacaaaacaat	2	12	5	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr19:35175342C>G	uc002nvr.1	+	6	795	c.532C>G	c.(532-534)CTT>GTT	p.L178V	ZNF302_uc002nvp.1_Missense_Mutation_p.L134V|ZNF302_uc002nvq.1_Missense_Mutation_p.L134V|ZNF302_uc002nvs.1_Missense_Mutation_p.L134V	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			AAAGTCTACTCTTTCTGAACC	0.274													G	35175342	G	G	35175342	3	3	107	1	0	0	0	0	1	0	0	0	17829	913	32	5	414	5	ZNF302	19	35175342	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	19149690	35175342	23953641	62	7392											
SHKBP1	92799	broad.mit.edu	37	chr19	41083170	41083170	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	cgccagactctcacctggatCccagactccttcttctccag	6	18	3	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr19:41083170C>A	uc002oob.2	+	2	169	c.120C>A	c.(118-120)ATC>ATA	p.I40I	SHKBP1_uc002ooc.2_Silent_p.I40I|SHKBP1_uc002ood.2_Silent_p.I40I|SHKBP1_uc010xvl.1_5'UTR|SHKBP1_uc002ooe.2_5'UTR|SHKBP1_uc002oof.2_5'Flank|SHKBP1_uc010xvm.1_5'Flank|SHKBP1_uc010xvn.1_5'Flank	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	40	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCACCTGGATCCCAGACTCCT	0.617													A	41083170	A	A	41083170	2	1	107	1	0	0	0	0	0	0	0	1	14284	845	30	5		5	SHKBP1	19	41083170	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08	5907828	41083170	18045813	63	7393											
SBK2	646643	broad.mit.edu	37	chr19	56047476	56047476	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccaggggacgcacttcctcGtagagctcgtccacctcggc	11	17	0	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr19:56047476G>A	uc010ygc.1	-	1	186	c.186C>T	c.(184-186)TAC>TAT	p.Y62Y		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	62	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0						GCACTTCCTCGTAGAGCTCGT	0.652													A	56047476	A	A	56047476	2	1	107	1	0	0	0	0	0	0	0	1	13861	1140	40	1		1	SBK2	19	56047476	Silent	SNP	G	TCGA-06-6699-01A-11D-1845-08	14964306	56047476	3081507	64	7394											
ADAM33	80332	broad.mit.edu	37	chr20	3655285	3655285	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagaagtccttggagccccGgggtggccagggacgcagat	17	10	0	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr20:3655285G>A	uc002wit.2	-	6	553	c.466C>T	c.(466-468)CGG>TGG	p.R156W	ADAM33_uc002wir.1_Missense_Mutation_p.R156W|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.R156W|ADAM33_uc002wiw.1_Intron|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Intron|ADAM33_uc010zqg.1_Missense_Mutation_p.R168W|ADAM33_uc010zqh.1_Missense_Mutation_p.R156W	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	156	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						TTGGAGCCCCGGGGTGGCCAG	0.607													A	3655285	A	A	3655285	3	1	107	1	0	0	0	0	1	0	0	0	250	1115	39	2	2043	2	ADAM33	20	3655285	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08		3655285	59370235	65	7395											
CHGB	1114	broad.mit.edu	37	chr20	5904558	5904558	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtatgagaagagaaacctcGccagggtccccaagctggac	13	11	0	2	rs148235020		TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr20:5904558G>A	uc002wmg.2	+	4	2074	c.1768G>A	c.(1768-1770)GCC>ACC	p.A590T	CHGB_uc010zqz.1_Missense_Mutation_p.A273T	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	590						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GAGAAACCTCGCCAGGGTCCC	0.498													A	5904558	A	A	5904558	3	1	107	1	0	0	0	0	1	0	0	0	3339	1087	38	1	1782	1	CHGB	20	5904558	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	2249273	5904558	57120962	66	7396											
PAK7	57144	broad.mit.edu	37	chr20	9543605	9543605	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catgaccacccagagctcatCgccgacaaggtagctgctgt	10	14	1	2			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr20:9543605C>T	uc002wnl.2	-	7	2094	c.1549G>A	c.(1549-1551)GAT>AAT	p.D517N	PAK7_uc002wnk.2_Missense_Mutation_p.D517N|PAK7_uc002wnj.2_Missense_Mutation_p.D517N|PAK7_uc010gby.1_Missense_Mutation_p.D517N	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	517	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CAGAGCTCATCGCCGACAAGG	0.478													T	9543605	T	T	9543605	3	4	107	1	0	0	0	0	1	0	0	0	11405	884	31	2	630	2	PAK7	20	9543605	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	3639047	9543605	53481915	67	7397											
COL20A1	57642	broad.mit.edu	37	chr20	61959711	61959711	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaaagttcgactccttccaCgagaacaccaggccccccat	6	17	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr20:61959711C>T	uc011aau.1	+	34	3742	c.3642C>T	c.(3640-3642)CAC>CAT	p.H1214H	COL20A1_uc011aav.1_Silent_p.H1041H	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1214					cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					ACTCCTTCCACGAGAACACCA	0.672													T	61959711	T	T	61959711	2	4	107	1	0	0	0	0	0	0	0	1	3679	535	19	1		1	COL20A1	20	61959711	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08	52416106	61959711	1065809	68	7398											
CLDN14	23562	broad.mit.edu	37	chr21	37833779	37833779	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggaggtcttggggcagcGccagcagggatcggtagatc	17	10	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr21:37833779G>A	uc002yvk.1	-	2	357	c.215C>T	c.(214-216)GCG>GTG	p.A72V	CLDN14_uc002yvn.1_Missense_Mutation_p.A72V|CLDN14_uc002yvo.1_Missense_Mutation_p.A72V|CLDN14_uc002yvl.1_Missense_Mutation_p.A72V|CLDN14_uc002yvm.1_Missense_Mutation_p.A72V	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	72	Extracellular (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TTGGGGCAGCGCCAGCAGGGA	0.632													A	37833779	A	A	37833779	3	1	107	1	0	0	0	0	1	0	0	0	3475	1087	38	1	508	1	CLDN14	21	37833779	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08		37833779	10296116	69	7399											
YWHAH	7533	broad.mit.edu	37	chr22	32352631	32352631	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcaagcctgcctcttagccaAacaagccttcgatgatgcca	8	14	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chr22:32352631A>G	uc003alz.2	+	2	834	c.593A>G	c.(592-594)AAA>AGA	p.K198R	YWHAH_uc010gwl.2_Missense_Mutation_p.K128R|YWHAH_uc003ama.2_Missense_Mutation_p.K128R|YWHAH_uc010gwm.2_Missense_Mutation_p.K185R	NM_003405	NP_003396	Q04917	1433F_HUMAN	tyrosine 3-monooxygenase/tryptophan	198					glucocorticoid catabolic process|glucocorticoid receptor signaling pathway|intracellular protein transport|negative regulation of dendrite morphogenesis|positive regulation of transcription, DNA-dependent|regulation of synaptic plasticity	cytoplasm	enzyme binding|glucocorticoid receptor binding|insulin-like growth factor receptor binding|protein domain specific binding			central_nervous_system(1)	1						CTCTTAGCCAAACAAGCCTTC	0.537													G	32352631	G	G	32352631	3	3	107	1	0	0	0	0	1	0	0	0	17501	14	1	4	599	4	YWHAH	22	32352631	Missense_Mutation	SNP	A	TCGA-06-6699-01A-11D-1845-08		32352631	18951935	70	7400											
FRMPD4	9758	broad.mit.edu	37	chrX	12516825	12516825	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgaagtcttcaggctggcCgcctccctcgggaacctggg	14	14	2	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chrX:12516825C>T	uc004cuz.1	+	2	574	c.68C>T	c.(67-69)CCG>CTG	p.P23L	FRMPD4_uc011mij.1_Missense_Mutation_p.P15L	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	23					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TCAGGCTGGCCGCCTCCCTCG	0.512													T	12516825	T	T	12516825	3	4	107	1	0	0	0	0	1	0	0	0	6059	652	23	2	74	2	FRMPD4	23	12516825	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08		12516825	142753735	71	7401											
CDKL5	6792	broad.mit.edu	37	chrX	18622187	18622187	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtcttagtccactgcacacCaaaacctaccaagcaagcag	6	14	1	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chrX:18622187C>A	uc004cym.2	+	12	1396	c.1143C>A	c.(1141-1143)ACC>ACA	p.T381T	CDKL5_uc004cyn.2_Silent_p.T381T	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	381					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CACTGCACACCAAAACCTACC	0.507													A	18622187	A	A	18622187	2	1	107	1	0	0	0	0	0	0	0	1	3157	581	21	5		5	CDKL5	23	18622187	Silent	SNP	C	TCGA-06-6699-01A-11D-1845-08	6105362	18622187	136648373	72	7402											
SYP	6855	broad.mit.edu	37	chrX	49048188	49048188	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aacacgaaccacaggttgccGacccagagcaccaggttcag	10	14	1	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chrX:49048188G>A	uc004dmz.1	-	6	664	c.648C>T	c.(646-648)GTC>GTT	p.V216V	SYP_uc011mmz.1_Silent_p.V98V|SYP_uc004dna.1_Silent_p.V210V	NM_003179	NP_003170	P08247	SYPH_HUMAN	synaptophysin	216	Helical; (Potential).|MARVEL.				regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle maturation|synaptic vesicle membrane organization	cell junction|integral to synaptic vesicle membrane|synaptosome	calcium ion binding|cholesterol binding|transporter activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(315;0.00016)				ACAGGTTGCCGACCCAGAGCA	0.677													A	49048188	A	A	49048188	2	1	107	1	0	0	0	0	0	0	0	1	15458	1045	37	2		2	SYP	23	49048188	Silent	SNP	G	TCGA-06-6699-01A-11D-1845-08	30426001	49048188	106222372	73	7403											
FOXP3	50943	broad.mit.edu	37	chrX	49112252	49112252	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcatccagaagatggtccGcctggcagtgcctaagtagg	12	11	1	2	rs2232369		TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chrX:49112252G>A	uc004dnf.3	-	7	847	c.659C>T	c.(658-660)GCG>GTG	p.A220V	FOXP3_uc011mnb.1_Missense_Mutation_p.A243V|FOXP3_uc011mnc.1_Missense_Mutation_p.A220V|FOXP3_uc004dne.3_Missense_Mutation_p.A185V|FOXP3_uc010niq.1_Missense_Mutation_p.A185V	NM_014009	NP_054728	Q9BZS1	FOXP3_HUMAN	forkhead box P3 isoform a	220	C2H2-type.				B cell homeostasis|cerebellum development|chromatin remodeling|embryo development|myeloid cell homeostasis|negative regulation of activated T cell proliferation|negative regulation of chronic inflammatory response|negative regulation of CREB transcription factor activity|negative regulation of cytokine secretion|negative regulation of histone acetylation|negative regulation of histone deacetylation|negative regulation of interferon-gamma biosynthetic process|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of interleukin-2 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of interleukin-6 production|negative regulation of isotype switching to IgE isotypes|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell cytokine production|negative regulation of tumor necrosis factor production|pattern specification process|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of histone acetylation|positive regulation of immature T cell proliferation in thymus|positive regulation of peripheral T cell tolerance induction|positive regulation of T cell anergy|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor-beta1 production|post-embryonic development|regulation of isotype switching to IgG isotypes|response to virus|T cell homeostasis|T cell receptor signaling pathway|tolerance induction to self antigen	cytoplasm|cytoplasm|nucleus|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|histone acetyltransferase binding|histone deacetylase binding|NF-kappaB binding|NFAT protein binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription corepressor activity|zinc ion binding				0	Ovarian(276;0.236)					AAGATGGTCCGCCTGGCAGTG	0.587													A	49112252	A	A	49112252	3	1	107	1	0	0	0	0	1	0	0	0	6028	1087	38	1	660	1	FOXP3	23	49112252	Missense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	64064	49112252	106158308	74	7404											
ITIH5L	347365	broad.mit.edu	37	chrX	54777784	54777784	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggcccggccttggtggtgCgccaagcagcttcccactca	13	15	1	0	rs146825535		TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chrX:54777784C>T	uc004dtj.2	-	12	3412	c.3382G>A	c.(3382-3384)GCA>ACA	p.A1128T		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	1128					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CTTGGTGGTGCGCCAAGCAGC	0.592													T	54777784	T	T	54777784	3	4	107	1	0	0	0	0	1	0	0	0	7908	768	27	1	567	1	ITIH5L	23	54777784	Missense_Mutation	SNP	C	TCGA-06-6699-01A-11D-1845-08	5665532	54777784	100492776	75	7405											
TEX11	56159	broad.mit.edu	37	chrX	69825267	69825267	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttacctgttcaaaagctgttGaagcttttctcccttgctct	6	11	3	1			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chrX:69825267G>T	uc004dyl.2	-	25	2258	c.2096C>A	c.(2095-2097)TCA>TAA	p.S699*	TEX11_uc004dyk.2_Nonsense_Mutation_p.S374*|TEX11_uc004dym.2_Nonsense_Mutation_p.S684*	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	699							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					AAAAGCTGTTGAAGCTTTTCT	0.388													T	69825267	T	T	69825267	4	4	107	1	0	0	0	0	0	1	0	0	15771	1294	45	5	754	5	TEX11	23	69825267	Nonsense_Mutation	SNP	G	TCGA-06-6699-01A-11D-1845-08	15047483	69825267	85445293	76	7406											
IL9R	3581	broad.mit.edu	37	chrX	155239824	155239824	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagcagcagcagcagcagcaAcaacaacaactactgtgcct	8	14	0	0			TCGA-06-6699-01A-11D-1845-08	TCGA-06-6699-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	90ba858d-e3bb-40d8-98ee-eeb127c58409	d5b55d58-8b00-41db-8a67-414f0577fc59	g.chrX:155239824A>G	uc004fnv.1	+	9	1495	c.1316A>G	c.(1315-1317)AAC>AGC	p.N439S	IL9R_uc004fnu.1_3'UTR	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	439	Poly-Asn.|Cytoplasmic (Potential).				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					agcagcagcaacaacaacaAC	0.517													G	155239824	G	G	155239824	3	3	107	1	0	0	0	0	1	0	0	0	7708	43	2	4	1350	4	IL9R	23	155239824	Missense_Mutation	SNP	A	TCGA-06-6699-01A-11D-1845-08	85414557	155239824	30736	77	7407											
ZBTB17	7709	broad.mit.edu	37	chr1	16268633	16268633	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatagaagtccgcgtctgtcTggaacatgaccagtgcctgg	13	10	2	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr1:16268633T>C	uc001axl.3	-	16	2482	c.2243A>G	c.(2242-2244)CAG>CGG	p.Q748R	ZBTB17_uc010obq.1_Missense_Mutation_p.Q665R|ZBTB17_uc010obr.1_Missense_Mutation_p.Q755R|ZBTB17_uc010obs.1_Missense_Mutation_p.Q672R	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	748	Interaction with HCFC1.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		CGCGTCTGTCTGGAACATGAC	0.627													C	16268633	C	C	16268633	3	2	108	1	0	0	0	0	1	0	0	0	17524	1580	55	4	172	4	ZBTB17	1	16268633	Missense_Mutation	SNP	T	TCGA-06-6700-01A-12D-1845-08		16268633	232981988	1	7408											
WDR63	126820	broad.mit.edu	37	chr1	85595746	85595746	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaacagcgcaaaaaaattcGtgagcaagaaaagaaagaaa	9	5	0	5			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr1:85595746G>A	uc001dkt.2	+	22	2674	c.2483G>A	c.(2482-2484)CGT>CAT	p.R828H	WDR63_uc009wcl.2_Missense_Mutation_p.R789H	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	828	Potential.									upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		AAAAAAATTCGTGAGCAAGAA	0.363													A	85595746	A	A	85595746	3	1	108	1	0	0	0	0	1	0	0	0	17311	1145	40	1	2565	1	WDR63	1	85595746	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	69327113	85595746	163654875	2	7409											
NUP210L	91181	broad.mit.edu	37	chr1	154062057	154062057	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacctggatgatttccaattCggaatgtgagaacctttaag	9	8	0	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr1:154062057C>T	uc001fdw.2	-	16	2273	c.2201G>A	c.(2200-2202)CGA>CAA	p.R734Q	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.R734Q	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	734						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ATTTCCAATTCGGAATGTGAG	0.423													T	154062057	T	T	154062057	3	4	108	1	0	0	0	0	1	0	0	0	10761	884	31	2	3565	2	NUP210L	1	154062057	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	68466311	154062057	95188564	3	7410											
TAGLN2	8407	broad.mit.edu	37	chr1	159889092	159889092	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagttgggatccccagagaAgagcccatcatctcgggcta	11	13	2	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr1:159889092A>G	uc001fum.1	-	3	480	c.430T>C	c.(430-432)TTC>CTC	p.F144L	CCDC19_uc001ful.2_Intron|TAGLN2_uc001fun.1_Missense_Mutation_p.F144L|TAGLN2_uc001fuo.1_Missense_Mutation_p.F144L	NM_003564	NP_003555	P37802	TAGL2_HUMAN	transgelin 2	144					muscle organ development	nuclear membrane|plasma membrane	protein binding				0	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCCCCAGAGAAGAGCCCATCA	0.547													G	159889092	G	G	159889092	3	3	108	1	0	0	0	0	1	0	0	0	15536	72	3	4	177	4	TAGLN2	1	159889092	Missense_Mutation	SNP	A	TCGA-06-6700-01A-12D-1845-08	5827035	159889092	89361529	4	7411											
CD244	51744	broad.mit.edu	37	chr1	160811483	160811483	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gctgccttgatgagaagactCaagttcttgactataaaact	8	8	2	4			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr1:160811483C>G	uc009wtq.2	-	2	448	c.270G>C	c.(268-270)TTG>TTC	p.L90F	CD244_uc001fxa.2_Missense_Mutation_p.L90F|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Missense_Mutation_p.L90F|CD244_uc010pjt.1_RNA	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	90	Extracellular (Potential).|Ig-like 1.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TGAGAAGACTCAAGTTCTTGA	0.448													G	160811483	G	G	160811483	3	3	108	1	0	0	0	0	1	0	0	0	2987	825	29	5	874	5	CD244	1	160811483	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	922391	160811483	88439138	5	7412											
HMCN1	83872	broad.mit.edu	37	chr1	186106708	186106708	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcatccaaaagaggagtcGtctgtgcaaccagccccttc	10	13	1	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr1:186106708G>A	uc001grq.1	+	88	13890	c.13661G>A	c.(13660-13662)CGT>CAT	p.R4554H	HMCN1_uc001grs.1_Missense_Mutation_p.R123H	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4554	TSP type-1 1.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AAGAGGAGTCGTCTGTGCAAC	0.488													A	186106708	A	A	186106708	3	1	108	1	0	0	0	0	1	0	0	0	7220	1145	40	1	14011	1	HMCN1	1	186106708	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	25295225	186106708	63143913	6	7413											
IGFN1	91156	broad.mit.edu	37	chr1	201196177	201196177	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacctggttcaagaatgacCgcagcctggaaggaaacccc	10	13	2	2	rs142381894		TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr1:201196177C>T	uc001gwc.2	+	12	3206	c.2434C>T	c.(2434-2436)CGC>TGC	p.R812C	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CAAGAATGACCGCAGCCTGGA	0.672													T	201196177	T	T	201196177	3	4	108	1	0	0	0	0	1	0	0	0	7590	652	23	2	11040	2	IGFN1	1	201196177	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	15089469	201196177	48054444	7	7414											
C1orf150	148823	broad.mit.edu	37	chr1	247712512	247712512	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatgggaaattatctcctgCgaaaactcaggtgagtcttg	11	7	3	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr1:247712512C>T	uc001idf.2	+	1	64	c.19C>T	c.(19-21)CGA>TGA	p.R7*	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_RNA|C1orf150_uc001idb.3_RNA|C1orf150_uc009xgx.2_Intron	NM_145278	NP_660321	Q5JQS6	CA150_HUMAN	hypothetical protein LOC148823	7											0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TTATCTCCTGCGAAAACTCAG	0.468													T	247712512	T	T	247712512	4	4	108	1	0	0	0	0	0	1	0	0	2004	760	27	1	21	1	C1orf150	1	247712512	Nonsense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	46516335	247712512	1538109	8	7415											
OR2T12	127064	broad.mit.edu	37	chr1	248458330	248458330	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtgtcagcacaagccaaaCgcaccaacacgggggcctcg	11	14	1	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr1:248458330C>T	uc010pzj.1	-	1	551	c.551G>A	c.(550-552)CGT>CAT	p.R184H		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ACAAGCCAAACGCACCAACAC	0.552													T	248458330	T	T	248458330	3	4	108	1	0	0	0	0	1	0	0	0	11019	536	19	1	414	1	OR2T12	1	248458330	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	745818	248458330	792291	9	7416											
LOC285033	285033	broad.mit.edu	37	chr2	96906137	96906137	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgtagcaggtaatttcttcCgaattcaaaaactcctcatg	6	10	3	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr2:96906137C>T	uc002svp.1	+	1	161	c.76C>T	c.(76-78)CGA>TGA	p.R26*	LOC285033_uc002svn.2_RNA|LOC285033_uc002svo.2_Intron	NM_001037228	NP_001032305	Q3KRF4	Q3KRF4_HUMAN	hypothetical protein LOC285033	26											0						TAATTTCTTCCGAATTCAAAA	0.408													T	96906137	T	T	96906137	4	4	108	1	0	0	0	0	0	1	0	0	8873	644	23	2	78	2	LOC285033	2	96906137	Nonsense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08		96906137	146293236	10	7417											
CNTNAP5	129684	broad.mit.edu	37	chr2	125530374	125530374	+	Splice_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgttttcctttccggtttcAgctccttcagagatcacctt	6	13	3	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr2:125530374A>T	uc002tno.2	+	17	2895	c.2531_splice	c.e17-2	p.S844_splice	CNTNAP5_uc010flu.2_Splice_Site_p.S845_splice	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TTCCGGTTTCAGCTCCTTCAG	0.458													T	125530374	T	T	125530374	5	4	108	1	0	0	0	0	0	0	1	0	3650	202	7	5	2595	5	CNTNAP5	2	125530374	Splice_Site	SNP	A	TCGA-06-6700-01A-12D-1845-08	28624237	125530374	117668999	11	7418											
FAM128B	80097	broad.mit.edu	37	chr2	130948160	130948160	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctaccaggctgcccaagggGggcgggcctgggaagagccc	18	13	0	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr2:130948160G>A	uc002tqu.2	+	3	591	c.438G>A	c.(436-438)GGG>GGA	p.G146G		NM_025029	NP_079305	Q6NZ67	MZT2B_HUMAN	hypothetical protein LOC80097	146						centrosome|gamma-tubulin ring complex|spindle	protein binding				0	Colorectal(110;0.1)					TGCCCAAGGGGGGCGGGCCTG	0.647													A	130948160	A	A	130948160	2	1	108	1	0	0	0	0	0	0	0	1	5435	1219	43	3		3	FAM128B	2	130948160	Silent	SNP	G	TCGA-06-6700-01A-12D-1845-08	5417786	130948160	112251213	12	7419											
ANKRD28	23243	broad.mit.edu	37	chr3	15712040	15712040	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccacatccttattgggagCacaggccaaagctggggtat	12	10	0	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr3:15712040C>T	uc003caj.1	-	28	3042	c.2899G>A	c.(2899-2901)GCT>ACT	p.A967T	ANKRD28_uc003cai.1_Missense_Mutation_p.A813T|ANKRD28_uc011avz.1_Missense_Mutation_p.A813T|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011avy.1_Missense_Mutation_p.A47T	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	967						nucleoplasm	protein binding			breast(1)	1						TTATTGGGAGCACAGGCCAAA	0.398													T	15712040	T	T	15712040	3	4	108	1	0	0	0	0	1	0	0	0	656	710	25	3	266	3	ANKRD28	3	15712040	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08		15712040	182310390	13	7420											
OXNAD1	92106	broad.mit.edu	37	chr3	16343240	16343240	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgattgcaggaggagtcggAattaaccctctgctttccat	10	9	1	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr3:16343240A>G	uc003caw.2	+	7	997	c.540A>G	c.(538-540)GGA>GGG	p.G180G	OXNAD1_uc010her.1_RNA|OXNAD1_uc003cax.2_Silent_p.G180G|OXNAD1_uc011awb.1_Silent_p.G198G	NM_138381	NP_612390	Q96HP4	OXND1_HUMAN	oxidoreductase NAD-binding domain containing 1	180	NAD (By similarity).|FAD-binding FR-type.						oxidoreductase activity			skin(1)	1						GAGGAGTCGGAATTAACCCTC	0.483													G	16343240	G	G	16343240	2	3	108	1	0	0	0	0	0	0	0	1	11333	233	9	4		4	OXNAD1	3	16343240	Silent	SNP	A	TCGA-06-6700-01A-12D-1845-08	631200	16343240	181679190	14	7421											
ZNF619	285267	broad.mit.edu	37	chr3	40529457	40529457	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaggaagaaactcatcaatGgaacagggctatccgcagtt	10	9	2	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr3:40529457G>A	uc011azb.1	+	6	1854	c.1576G>A	c.(1576-1578)GGA>AGA	p.G526R	ZNF619_uc010hhz.2_Missense_Mutation_p.G477R|ZNF619_uc003ckj.2_Missense_Mutation_p.G470R|ZNF619_uc011azc.1_Missense_Mutation_p.G486R|ZNF619_uc011azd.1_Missense_Mutation_p.G442R|ZNF619_uc011aza.1_Missense_Mutation_p.G428R	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	526					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		ACTCATCAATGGAACAGGGCT	0.537													A	40529457	A	A	40529457	3	1	108	1	0	0	0	0	1	0	0	0	18040	1349	47	3	1616	3	ZNF619	3	40529457	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	24186217	40529457	157492973	15	7422											
RBM15B	29890	broad.mit.edu	37	chr3	51430156	51430156	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgagagtttgaccgctttggGagcattcggaccattgatca	12	9	1	3			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr3:51430156G>A	uc003dbd.2	+	1	1426	c.1326G>A	c.(1324-1326)GGG>GGA	p.G442G		NM_013286	NP_037418	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	442	RRM 3.				interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		ACCGCTTTGGGAGCATTCGGA	0.572													A	51430156	A	A	51430156	2	1	108	1	0	0	0	0	0	0	0	1	13117	1161	41	3		3	RBM15B	3	51430156	Silent	SNP	G	TCGA-06-6700-01A-12D-1845-08	10900699	51430156	146592274	16	7423											
BOD1L	259282	broad.mit.edu	37	chr4	13603360	13603360	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgtcacagtgccctctgtttCttttttgggacccattctca	7	12	4	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr4:13603360C>T	uc003gmz.1	-	10	5281	c.5164G>A	c.(5164-5166)GAA>AAA	p.E1722K	BOD1L_uc010idr.1_Missense_Mutation_p.E1059K	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1722							DNA binding			ovary(5)|breast(1)	6						CCCTCTGTTTCTTTTTTGGGA	0.493													T	13603360	T	T	13603360	3	4	108	1	0	0	0	0	1	0	0	0	1483	922	32	3	4059	3	BOD1L	4	13603360	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08		13603360	177550916	17	7424											
UGT8	7368	broad.mit.edu	37	chr4	115544445	115544445	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaaaatttgacctgctgctgGtggaccctaatgatatgtgt	10	7	0	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr4:115544445G>C	uc003ibs.2	+	2	931	c.409G>C	c.(409-411)GTG>CTG	p.V137L	UGT8_uc003ibt.2_Missense_Mutation_p.V137L|UGT8_uc011cge.1_RNA	NM_001128174	NP_001121646	Q16880	CGT_HUMAN	UDP-galactose-ceramide galactosyltransferase 8	137					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		CCTGCTGCTGGTGGACCCTAA	0.438													C	115544445	C	C	115544445	3	2	108	1	0	0	0	0	1	0	0	0	16962	1261	44	5	411	5	UGT8	4	115544445	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	101941085	115544445	75609831	18	7425											
ODZ3	55714	broad.mit.edu	37	chr4	183714528	183714528	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttatgacggcctgggaaggCgtgtttctagcaaaaccagt	13	8	1	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr4:183714528C>T	uc003ivd.1	+	25	6740	c.6703C>T	c.(6703-6705)CGT>TGT	p.R2235C		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2235	YD 22.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CCTGGGAAGGCGTGTTTCTAG	0.453													T	183714528	T	T	183714528	3	4	108	1	0	0	0	0	1	0	0	0	10836	768	27	1	6801	1	ODZ3	4	183714528	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	68170083	183714528	7439748	19	7426											
MARCH6	10299	broad.mit.edu	37	chr5	10394249	10394249	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgctgaagagcttacatgGgaaagagtaagacctttttc	11	7	0	4			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr5:10394249G>A	uc003jet.1	+	8	1005	c.822G>A	c.(820-822)TGG>TGA	p.W274*	MARCH6_uc011cmu.1_Nonsense_Mutation_p.W226*|MARCH6_uc003jeu.1_5'UTR|MARCH6_uc011cmv.1_Nonsense_Mutation_p.W169*	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	274	Cytoplasmic (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						AGCTTACATGGGAAAGAGTAA	0.303													A	10394249	A	A	10394249	4	1	108	1	0	0	0	0	0	1	0	0	9305	1241	43	3	852	3	MARCH6	5	10394249	Nonsense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08		10394249	170521011	20	7427											
SLC26A2	1836	broad.mit.edu	37	chr5	149360771	149360771	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgttggggtttgtttttctAtattttgtgtcatcctccgc	9	7	2	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr5:149360771A>G	uc003lrh.2	+	3	1883	c.1615A>G	c.(1615-1617)ATA>GTA	p.I539V		NM_000112	NP_000103	P50443	S26A2_HUMAN	solute carrier family 26 member 2	539	Helical; (Potential).					integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TTGTTTTTCTATATTTTGTGT	0.423													G	149360771	G	G	149360771	3	3	108	1	0	0	0	0	1	0	0	0	14517	449	16	4	1621	4	SLC26A2	5	149360771	Missense_Mutation	SNP	A	TCGA-06-6700-01A-12D-1845-08	138966522	149360771	31554489	21	7428											
VARS	7407	broad.mit.edu	37	chr6	31746760	31746760	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acaccttggcttcatctgccTcctggacttcgagcggcacc	9	16	2	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr6:31746760T>C	uc003nxe.2	-	29	4133	c.3710A>G	c.(3709-3711)GAG>GGG	p.E1237G	C6orf27_uc011dog.1_5'Flank|C6orf27_uc003nxd.2_5'Flank|C6orf27_uc011doh.1_5'Flank|VARS_uc003nxf.1_Missense_Mutation_p.E174G	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	1237					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	TTCATCTGCCTCCTGGACTTC	0.562													C	31746760	C	C	31746760	3	2	108	1	0	0	0	0	1	0	0	0	17120	1551	54	4	92	4	VARS	6	31746760	Missense_Mutation	SNP	T	TCGA-06-6700-01A-12D-1845-08		31746760	139368307	22	7429											
SLC22A7	10864	broad.mit.edu	37	chr6	43269393	43269393	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagacctgttccgcacaccaCggctccgacacatctcactg	7	17	1	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr6:43269393C>T	uc003out.2	+	7	1123	c.1024C>T	c.(1024-1026)CGG>TGG	p.R342W	SLC22A7_uc010jyl.1_Missense_Mutation_p.R343W|SLC22A7_uc003ous.2_Missense_Mutation_p.R340W	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	342						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CCGCACACCACGGCTCCGACA	0.617													T	43269393	T	T	43269393	3	4	108	1	0	0	0	0	1	0	0	0	14459	527	19	1	1046	1	SLC22A7	6	43269393	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	11522633	43269393	127845674	23	7430											
GFRAL	389400	broad.mit.edu	37	chr6	55264168	55264168	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aatctttttctttttctaggAgaagtaatctatgctgccat	6	7	4	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr6:55264168A>T	uc003pcm.1	+	8	1136	c.1050A>T	c.(1048-1050)GGA>GGT	p.G350G		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	350	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTTTTCTAGGAGAAGTAATCT	0.313													T	55264168	T	T	55264168	2	4	108	1	0	0	0	0	0	0	0	1	6351	318	11	5		5	GFRAL	6	55264168	Silent	SNP	A	TCGA-06-6700-01A-12D-1845-08	11994775	55264168	115850899	24	7431											
IMPG1	3617	broad.mit.edu	37	chr6	76731930	76731930	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggcccaagtgagacgttgGcaacatctgtgaaaatttta	10	7	1	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr6:76731930G>A	uc003pik.1	-	6	699	c.569C>T	c.(568-570)GCC>GTC	p.A190V		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	190					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TGAGACGTTGGCAACATCTGT	0.378													A	76731930	A	A	76731930	3	1	108	1	0	0	0	0	1	0	0	0	7728	1203	42	3	1872	3	IMPG1	6	76731930	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	21467762	76731930	94383137	25	7432											
SLC22A3	6581	broad.mit.edu	37	chr6	160828117	160828117	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctatcctgccttggtgttgGcgtcactggggttgtggtgg	17	8	1	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr6:160828117G>A	uc003qti.2	+	3	605	c.578G>A	c.(577-579)GGC>GAC	p.G193D	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	193	Helical; (Potential).					integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		CTTGGTGTTGGCGTCACTGGG	0.473													A	160828117	A	A	160828117	3	1	108	1	0	0	0	0	1	0	0	0	14455	1203	42	3	588	3	SLC22A3	6	160828117	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	84096187	160828117	10286950	26	7433											
EGFR	1956	broad.mit.edu	37	chr7	55268881	55268881	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcaaaatctctgcaccagGgggatgaaagaatgcatttg	10	9	2	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr7:55268881G>A	uc003tqk.2	+	25	3193	c.2947G>A	c.(2947-2949)GGG>AGG	p.G983R	EGFR_uc010kzg.1_Missense_Mutation_p.G938R|EGFR_uc011kco.1_Missense_Mutation_p.G930R	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	983	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCTGCACCAGGGGGATGAAAG	0.512		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55268881	A	A	55268881	3	1	108	1	0	0	0	0	1	0	0	0	4967	1246	43	3	3309	3	EGFR	7	55268881	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08		55268881	103869782	27	7434											
PCLO	27445	broad.mit.edu	37	chr7	82595087	82595087	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttagtaaaatttaacttacTgttttttctttcccaggttc	5	7	1	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr7:82595087T>C	uc003uhx.2	-	4	4306	c.4017A>G	c.(4015-4017)ACA>ACG	p.T1339T	PCLO_uc003uhv.2_Silent_p.T1339T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTAACTTACTGTTTTTTCTT	0.338													C	82595087	C	C	82595087	2	2	108	1	0	0	0	0	0	0	0	1	11583	1594	55	4		4	PCLO	7	82595087	Silent	SNP	T	TCGA-06-6700-01A-12D-1845-08	27326206	82595087	76543576	28	7435											
AKR1B10	57016	broad.mit.edu	37	chr7	134222353	134222353	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gccaagccagaagacccttcCctgctggaggatcccaagat	10	14	0	3			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr7:134222353C>G	uc003vrr.2	+	7	1001	c.681C>G	c.(679-681)TCC>TCG	p.S227S		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	227					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						AAGACCCTTCCCTGCTGGAGG	0.463													G	134222353	G	G	134222353	2	3	108	1	0	0	0	0	0	0	0	1	467	610	22	5		5	AKR1B10	7	134222353	Silent	SNP	C	TCGA-06-6700-01A-12D-1845-08	51627266	134222353	24916310	29	7436											
EPHA1	2041	broad.mit.edu	37	chr7	143097029	143097029	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcacccgggttgtggaaagCgaggtagaggccacggcggg	20	9	0	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr7:143097029C>T	uc003wcz.2	-	4	637	c.550G>A	c.(550-552)GCT>ACT	p.A184T		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	184	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TTGTGGAAAGCGAGGTAGAGG	0.617													T	143097029	T	T	143097029	3	4	108	1	0	0	0	0	1	0	0	0	5165	768	27	1	2440	1	EPHA1	7	143097029	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	8874676	143097029	16041634	30	7437											
NCAPG2	54892	broad.mit.edu	37	chr7	158447341	158447341	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ttgcatctgaaactgatggtCaccaaggcctaccataacaa	7	11	2	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr7:158447341C>A	uc003wnv.1	-	22	2837	c.2692G>T	c.(2692-2694)GAC>TAC	p.D898Y	NCAPG2_uc010lqu.1_Missense_Mutation_p.D690Y|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Missense_Mutation_p.D898Y|NCAPG2_uc011kwe.1_Missense_Mutation_p.D898Y|NCAPG2_uc011kwc.1_Missense_Mutation_p.D399Y|NCAPG2_uc011kwd.1_Missense_Mutation_p.D341Y	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	898					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		AACTGATGGTCACCAAGGCCT	0.428													A	158447341	A	A	158447341	3	1	108	1	0	0	0	0	1	0	0	0	10208	826	29	5	767	5	NCAPG2	7	158447341	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	15350312	158447341	691322	31	7438											
NKAIN3	286183	broad.mit.edu	37	chr8	63659690	63659691	+	Splice_Site	INS	-	A	A													gtccaaatactactctctgtINSaagtgtcacttttgtgtcat							TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr8:63659690_63659691insA	uc010lyq.1	+	4	603	c.471_splice	c.e4+2	p.S157_splice		NM_173688	NP_775959	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3							integral to membrane|plasma membrane					0	Breast(64;0.127)	Lung NSC(129;0.187)				CTACTCTCTGTAAGTGTCACTT	0.441													A	63659691	A	A	63659690	8	5	108	1	0	1	1	0	0	0	1	0	10437	1652	57	0	487	0	NKAIN3	8	63659690	Splice_Site	INS	-	TCGA-06-6700-01A-12D-1845-08		63659690	82704332	32	7439											
OR10A6	390093	broad.mit.edu	37	chr11	7949287	7949287	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agattgtgtgtaaaaccactCgccttcgccataatttcatc	6	11	1	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr11:7949287C>T	uc010rbh.1	-	1	923	c.923G>A	c.(922-924)CGA>CAA	p.R308Q		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TAAAACCACTCGCCTTCGCCA	0.363													T	7949287	T	T	7949287	3	4	108	1	0	0	0	0	1	0	0	0	10894	884	31	2	24	2	OR10A6	11	7949287	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08		7949287	127057229	33	7440											
AMBRA1	55626	broad.mit.edu	37	chr11	46439460	46439461	+	Splice_Site	INS	-	A	A													ccccacactttaagccacttINSactctggtcggcagatcacc							TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr11:46439460_46439461insA	uc010rgu.1	-	15	3476	c.3116_splice	c.e15+1	p.E1039_splice	AMBRA1_uc010rgt.1_Splice_Site_p.E605_splice|AMBRA1_uc009ylc.1_Splice_Site_p.E1010_splice|AMBRA1_uc001ncu.1_Splice_Site_p.E949_splice|AMBRA1_uc001ncv.2_Splice_Site_p.E1042_splice|AMBRA1_uc001ncw.2_Splice_Site_p.E920_splice|AMBRA1_uc001ncx.2_Splice_Site_p.E979_splice	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated						autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		TTAAGCCACTTACTCTGGTCGG	0.525													A	46439461	A	A	46439460	8	5	108	1	0	1	1	0	0	0	1	0	565	1769	61	0		0	AMBRA1	11	46439460	Splice_Site	INS	-	TCGA-06-6700-01A-12D-1845-08	38490173	46439460	88567056	34	7441											
OR5A1	219982	broad.mit.edu	37	chr11	59211010	59211010	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctgactgctatggcataCgaccgatatgcagccatctc	8	14	1	1	rs139346783	byFrequency	TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr11:59211010C>T	uc001nnx.1	+	1	369	c.369C>T	c.(367-369)TAC>TAT	p.Y123Y		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	123	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						CTATGGCATACGACCGATATG	0.542													T	59211010	T	T	59211010	2	4	108	1	0	0	0	0	0	0	0	1	11139	547	19	1		1	OR5A1	11	59211010	Silent	SNP	C	TCGA-06-6700-01A-12D-1845-08	12771550	59211010	75795506	35	7442											
STX3	6809	broad.mit.edu	37	chr11	59564776	59564776	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaattgataattatcattgtGctagtagttgtgttgctggg	11	3	1	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr11:59564776G>T	uc001nog.2	+	10	997	c.807G>T	c.(805-807)GTG>GTT	p.V269V	STX3_uc010rkx.1_Intron|STX3_uc010rky.1_Intron|STX3_uc009ymt.1_Silent_p.V135V	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	269	Helical; Anchor for type IV membrane protein; (Potential).				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						TTATCATTGTGCTAGTAGTTG	0.363													T	59564776	T	T	59564776	2	4	108	1	0	0	0	0	0	0	0	1	15345	1306	46	5		5	STX3	11	59564776	Silent	SNP	G	TCGA-06-6700-01A-12D-1845-08	353766	59564776	75441740	36	7443											
SLC3A2	6520	broad.mit.edu	37	chr11	62652817	62652817	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aatgccactggcaatcgctgGtgcagctggagtgtgagtac	14	9	0	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr11:62652817G>T	uc001nwd.2	+	9	1514	c.1290G>T	c.(1288-1290)TGG>TGT	p.W430C	SLC3A2_uc001nwb.2_Missense_Mutation_p.W461C|SLC3A2_uc001nwc.2_Missense_Mutation_p.W431C|SLC3A2_uc001nwe.2_Missense_Mutation_p.W399C|SLC3A2_uc001nwf.2_Missense_Mutation_p.W368C|SLC3A2_uc001nwg.2_Missense_Mutation_p.W329C	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	430	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						GCAATCGCTGGTGCAGCTGGA	0.517													T	62652817	T	T	62652817	3	4	108	1	0	0	0	0	1	0	0	0	14627	1270	44	5	1424	5	SLC3A2	11	62652817	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	3088041	62652817	72353699	37	7444											
MFAP5	8076	broad.mit.edu	37	chr12	8813465	8813465	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagggttcacctacctcctcGttgactattgacccccaggg	9	14	1	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr12:8813465G>A	uc001qut.1	-	3	301	c.88C>T	c.(88-90)CGA>TGA	p.R30*	MFAP5_uc001qus.2_Nonsense_Mutation_p.R30*|MFAP5_uc009zge.1_Nonsense_Mutation_p.R30*	NM_003480	NP_003471	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5 precursor	30	Cell attachment site (Potential).					microfibril	extracellular matrix structural constituent			breast(1)	1	Lung SC(5;0.184)					CTACCTCCTCGTTGACTATTG	0.438													A	8813465	A	A	8813465	4	1	108	1	0	0	0	0	0	1	0	0	9518	1153	40	1	465	1	MFAP5	12	8813465	Nonsense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08		8813465	125038430	38	7445											
CD63	967	broad.mit.edu	37	chr12	56120552	56120552	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtaattctccatctgctgccGgaagttgttattaaactctg	8	9	3	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr12:56120552G>A	uc001shm.2	-	4	454	c.358C>T	c.(358-360)CGG>TGG	p.R120W	CD63_uc009znz.2_Missense_Mutation_p.R97W|CD63_uc001shn.2_Missense_Mutation_p.R120W|CD63_uc001sho.2_Missense_Mutation_p.R120W|CD63_uc001shp.2_Missense_Mutation_p.R120W	NM_001780	NP_001771	P08962	CD63_HUMAN	CD63 antigen isoform A	120	Extracellular (Potential).				platelet activation|platelet degranulation	integral to plasma membrane|late endosome membrane|lysosomal membrane|platelet dense granule membrane					0						ATCTGCTGCCGGAAGTTGTTA	0.557													A	56120552	A	A	56120552	3	1	108	1	0	0	0	0	1	0	0	0	3029	1115	39	2	374	2	CD63	12	56120552	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	47307087	56120552	77731343	39	7446											
TMEM132B	114795	broad.mit.edu	37	chr12	126138636	126138636	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatgcctttacaagcttcCccactcaagggaagtcaccg	8	14	2	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr12:126138636C>T	uc001uhe.1	+	9	2625	c.2617C>T	c.(2617-2619)CCC>TCC	p.P873S	TMEM132B_uc001uhf.1_Missense_Mutation_p.P385S	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	873	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TACAAGCTTCCCCACTCAAGG	0.507													T	126138636	T	T	126138636	3	4	108	1	0	0	0	0	1	0	0	0	16043	623	22	3	2651	3	TMEM132B	12	126138636	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	70018084	126138636	7713259	40	7447											
EP400	57634	broad.mit.edu	37	chr12	132514624	132514624	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acagatgattcttatgttggAcattttagagatgttcttga	9	4	2	4			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr12:132514624A>G	uc001ujn.2	+	28	5710	c.5675A>G	c.(5674-5676)GAC>GGC	p.D1892G	EP400_uc001ujl.2_Missense_Mutation_p.D1891G|EP400_uc001ujm.2_Missense_Mutation_p.D1811G|SNORA49_uc001ujo.2_5'Flank	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1928	Helicase C-terminal.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CTTATGTTGGACATTTTAGAG	0.413													G	132514624	G	G	132514624	3	3	108	1	0	0	0	0	1	0	0	0	5149	275	10	4	5782	4	EP400	12	132514624	Missense_Mutation	SNP	A	TCGA-06-6700-01A-12D-1845-08	6375988	132514624	1337271	41	7448											
FLT1	2321	broad.mit.edu	37	chr13	28896953	28896953	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcctcaacatcactcagaCttttatcttcctgaaagccg	4	14	4	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr13:28896953C>T	uc001usb.3	-	21	3212	c.2927G>A	c.(2926-2928)AGT>AAT	p.S976N	FLT1_uc010aap.2_5'Flank|FLT1_uc010aaq.2_Missense_Mutation_p.S101N|FLT1_uc001usa.3_Missense_Mutation_p.S194N	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	976	Cytoplasmic (Potential).|Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	ATCACTCAGACTTTTATCTTC	0.438													T	28896953	T	T	28896953	3	4	108	1	0	0	0	0	1	0	0	0	5941	565	20	3	1129	3	FLT1	13	28896953	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08		28896953	86272925	42	7449											
PCCA	5095	broad.mit.edu	37	chr13	100915068	100915068	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaaaatttattgataatcctCgtcatatagaaatccaggtt	5	6	1	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr13:100915068C>T	uc001voo.2	+	10	840	c.802C>T	c.(802-804)CGT>TGT	p.R268C	PCCA_uc010aga.2_Missense_Mutation_p.R242C|PCCA_uc010tiz.1_Missense_Mutation_p.R268C	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	268	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	TGATAATCCTCGTCATATAGA	0.274													T	100915068	T	T	100915068	3	4	108	1	0	0	0	0	1	0	0	0	11504	884	31	2	840	2	PCCA	13	100915068	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	72018115	100915068	14254810	43	7450											
GRTP1	79774	broad.mit.edu	37	chr13	114009782	114009782	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccagcgggacccctttccGgacatagcgcttcactgaag	10	15	1	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr13:114009782G>A	uc001vtn.2	-	3	293	c.196C>T	c.(196-198)CGG>TGG	p.R66W	GRTP1_uc010tkb.1_5'UTR|GRTP1_uc010tkc.1_Missense_Mutation_p.R66W|GRTP1_uc010agv.1_RNA	NM_024719	NP_078995	Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	66						intracellular	Rab GTPase activator activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			ACCCCTTTCCGGACATAGCGC	0.657													A	114009782	A	A	114009782	3	1	108	1	0	0	0	0	1	0	0	0	6810	1115	39	2	838	2	GRTP1	13	114009782	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	13094714	114009782	1160096	44	7451											
CMA1	1215	broad.mit.edu	37	chr14	24976583	24976583	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcctgcacaatgagcagccGtcagcacaaagttccgtctt	8	13	2	1	rs13306251	by1000genomes	TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr14:24976583G>A	uc001wpp.1	-	2	218	c.188C>T	c.(187-189)ACG>ATG	p.T63M	CMA1_uc010alx.1_Intron	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	63	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		ATGAGCAGCCGTCAGCACAAA	0.488													A	24976583	A	A	24976583	3	1	108	1	0	0	0	0	1	0	0	0	3574	1145	40	1	571	1	CMA1	14	24976583	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08		24976583	82372957	45	7452											
KIAA1409	57578	broad.mit.edu	37	chr14	94103593	94103593	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgggaaacgccagtgtaaCgtgccaacgtgcctaaaccc	10	14	0	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr14:94103593C>T	uc001ybv.1	+	31	5483	c.5400C>T	c.(5398-5400)AAC>AAT	p.N1800N	KIAA1409_uc001ybs.1_Silent_p.N1778N	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1955						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		gccagtgtaacgtgccaacgt	0.005													T	94103593	T	T	94103593	2	4	108	1	0	0	0	0	0	0	0	1	8230	535	19	1		1	KIAA1409	14	94103593	Silent	SNP	C	TCGA-06-6700-01A-12D-1845-08	69127010	94103593	13245947	46	7453											
GABRA5	2558	broad.mit.edu	37	chr15	27193304	27193304	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtattcccagtcttgttcgGcactttcaacttagtttact	6	11	2	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr15:27193304G>A	uc001zbd.1	+	12	1652	c.1313G>A	c.(1312-1314)GGC>GAC	p.G438D	GABRA5_uc001zbe.1_RNA	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	438	Helical; (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTCTTGTTCGGCACTTTCAAC	0.438													A	27193304	A	A	27193304	3	1	108	1	0	0	0	0	1	0	0	0	6164	1203	42	3	1347	3	GABRA5	15	27193304	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08		27193304	75338088	47	7454											
PCSK6	5046	broad.mit.edu	37	chr15	101971636	101971636	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcctggacattcatttcCgaccggcagcgactgttctt	10	13	2	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr15:101971636C>T	uc002bwy.2	-	5	860	c.546G>A	c.(544-546)TCG>TCA	p.S182S	PCSK6_uc010bpd.2_Silent_p.S52S|PCSK6_uc010bpe.2_Silent_p.S182S|PCSK6_uc002bxa.2_Silent_p.S182S|PCSK6_uc002bxb.2_Silent_p.S182S|PCSK6_uc002bxc.1_Silent_p.S182S|PCSK6_uc002bxd.1_Silent_p.S182S|PCSK6_uc002bxe.2_Silent_p.S182S|PCSK6_uc002bxg.1_Silent_p.S182S	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	182	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CATTCATTTCCGACCGGCAGC	0.532													T	101971636	T	T	101971636	2	4	108	1	0	0	0	0	0	0	0	1	11604	639	23	2		2	PCSK6	15	101971636	Silent	SNP	C	TCGA-06-6700-01A-12D-1845-08	74778332	101971636	559756	48	7455											
EDC4	23644	broad.mit.edu	37	chr16	67917522	67917522	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtatgtgtgtgaaactgtgGacccagcccaggtttttggg	14	7	0	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr16:67917522G>A	uc002eur.2	+	28	4067	c.3901G>A	c.(3901-3903)GAC>AAC	p.D1301N	EDC4_uc010cer.2_Missense_Mutation_p.D920N|EDC4_uc002eus.2_Missense_Mutation_p.D1031N|EDC4_uc002eut.1_3'UTR|NRN1L_uc002euu.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	1301					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TGAAACTGTGGACCCAGCCCA	0.547											OREG0023890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	67917522	A	A	67917522	3	1	108	1	0	0	0	0	1	0	0	0	4908	1174	41	3	4011	3	EDC4	16	67917522	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08		67917522	22437231	49	7456											
PDPR	55066	broad.mit.edu	37	chr16	70172800	70172800	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacgtgccctctgtctatatAggtaccttgccgaatggatg	10	11	2	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr16:70172800A>G	uc002eyf.1	+	11	2148	c.1191_splice	c.e11-2	p.K397_splice	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Splice_Site_p.K297_splice|PDPR_uc002eyg.1_Splice_Site_p.K125_splice	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory						glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		CTGTCTATATAGGTACCTTGC	0.443													G	70172800	G	G	70172800	5	3	108	1	0	0	0	0	0	0	1	0	11689	434	15	4	1223	4	PDPR	16	70172800	Splice_Site	SNP	A	TCGA-06-6700-01A-12D-1845-08	2255278	70172800	20181953	50	7457											
PIK3R5	23533	broad.mit.edu	37	chr17	8784974	8784974	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcccttcttggatttggaGttctgccttttcaccacttc	7	12	3	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr17:8784974G>A	uc002glt.2	-	17	2422	c.2355C>T	c.(2353-2355)AAC>AAT	p.N785N	PIK3R5_uc010vuz.1_Silent_p.N785N|PIK3R5_uc002glu.3_Silent_p.N399N	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	785					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						TGGATTTGGAGTTCTGCCTTT	0.493													A	8784974	A	A	8784974	2	1	108	1	0	0	0	0	0	0	0	1	11922	1020	36	3		3	PIK3R5	17	8784974	Silent	SNP	G	TCGA-06-6700-01A-12D-1845-08		8784974	72410236	51	7458											
SPACA3	124912	broad.mit.edu	37	chr17	31322667	31322667	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaggccaagctctacggtcGttgtgaactggccagagtgc	14	10	1	3			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr17:31322667G>A	uc002hhs.1	+	2	350	c.275G>A	c.(274-276)CGT>CAT	p.R92H	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	92	Extracellular (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			CTCTACGGTCGTTGTGAACTG	0.617													A	31322667	A	A	31322667	3	1	108	1	0	0	0	0	1	0	0	0	14973	1145	40	1	281	1	SPACA3	17	31322667	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	22537693	31322667	49872543	52	7459											
C17orf57	124989	broad.mit.edu	37	chr17	45490276	45490276	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcccttaactgttgtaacGtcagtggtgagcattttttt	9	7	1	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr17:45490276G>A	uc002iln.2	+	22	2827	c.2416G>A	c.(2416-2418)GTC>ATC	p.V806I	C17orf57_uc002ilm.2_Missense_Mutation_p.V710I	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	806	EF-hand 5.						calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						CTGTTGTAACGTCAGTGGTGA	0.353													A	45490276	A	A	45490276	3	1	108	1	0	0	0	0	1	0	0	0	1865	1145	40	1	2490	1	C17orf57	17	45490276	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	14167609	45490276	35704934	53	7460											
SPAG9	9043	broad.mit.edu	37	chr17	49071128	49071128	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatgactcactcttacctgGcacacttgcaatgcacagaa	7	13	2	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr17:49071128G>A	uc002itc.2	-	19	2604	c.2395C>T	c.(2395-2397)CCA>TCA	p.P799S	SPAG9_uc002itb.2_Missense_Mutation_p.P785S|SPAG9_uc002itd.2_Missense_Mutation_p.P789S|SPAG9_uc002itf.2_Missense_Mutation_p.P620S|SPAG9_uc002ita.2_Missense_Mutation_p.P642S|SPAG9_uc002ite.2_Missense_Mutation_p.P629S	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	799					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			CTCTTACCTGGCACACTTGCA	0.328													A	49071128	A	A	49071128	3	1	108	1	0	0	0	0	1	0	0	0	14985	1203	42	3	1618	3	SPAG9	17	49071128	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	3580852	49071128	32124082	54	7461											
C18orf34	374864	broad.mit.edu	37	chr18	30825371	30825371	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatattttatttcagattcGtattttgattttttccgtat	4	4	1	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr18:30825371G>A	uc002kxn.2	-	14	1573	c.1431C>T	c.(1429-1431)TAC>TAT	p.Y477Y	C18orf34_uc010dme.1_Translation_Start_Site|C18orf34_uc010xbr.1_Silent_p.Y477Y|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Silent_p.Y477Y|C18orf34_uc002kxp.2_Silent_p.Y477Y	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	477										ovary(1)	1						TTTCAGATTCGTATTTTGATT	0.259													A	30825371	A	A	30825371	2	1	108	1	0	0	0	0	0	0	0	1	1902	1140	40	1		1	C18orf34	18	30825371	Silent	SNP	G	TCGA-06-6700-01A-12D-1845-08		30825371	47251877	55	7462											
CELF4	56853	broad.mit.edu	37	chr18	35145598	35145598	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgctaacgtggccatctttaTatacatagagaaaatcttct	6	8	3	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr18:35145598T>A	uc002lae.2	-	1	403	c.7A>T	c.(7-9)ATA>TTA	p.I3L	CELF4_uc010dnd.1_Missense_Mutation_p.I3L|CELF4_uc002lag.2_Missense_Mutation_p.I3L|CELF4_uc002laf.2_5'UTR|CELF4_uc002lai.2_5'UTR	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	3	Sufficient for RNA-binding and MSE- dependent splicing activity.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						GCCATCTTTATATACATAGAG	0.537													A	35145598	A	A	35145598	3	1	108	1	0	0	0	0	1	0	0	0	3218	1406	49	5	1501	5	CELF4	18	35145598	Missense_Mutation	SNP	T	TCGA-06-6700-01A-12D-1845-08	4320227	35145598	42931650	56	7463											
SERPINB4	6318	broad.mit.edu	37	chr18	61306946	61306946	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccctttgaaatagattgcGttcacaagaaccagtgtcgt	9	9	1	3			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr18:61306946G>A	uc002ljf.2	-	6	620	c.534C>T	c.(532-534)AAC>AAT	p.N178N	SERPINB4_uc002lje.2_Silent_p.N178N|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	178					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						AATAGATTGCGTTCACAAGAA	0.318													A	61306946	A	A	61306946	2	1	108	1	0	0	0	0	0	0	0	1	14103	1136	40	1		1	SERPINB4	18	61306946	Silent	SNP	G	TCGA-06-6700-01A-12D-1845-08	26161348	61306946	16770302	57	7464											
CYP2F1	1572	broad.mit.edu	37	chr19	41630793	41630793	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actagggacacggcctttcgCggcttcctgatacccaaggt	11	13	0	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr19:41630793C>T	uc002opu.1	+	8	1190	c.1134C>T	c.(1132-1134)CGC>CGT	p.R378R	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_3'UTR|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	378					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						CGGCCTTTCGCGGCTTCCTGA	0.597													T	41630793	T	T	41630793	2	4	108	1	0	0	0	0	0	0	0	1	4171	755	27	1		1	CYP2F1	19	41630793	Silent	SNP	C	TCGA-06-6700-01A-12D-1845-08		41630793	17498190	58	7465											
ZNF813	126017	broad.mit.edu	37	chr19	53995185	53995185	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttaatcaaaaagcacaccttGcacgtcaccatagacttcat	4	12	3	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr19:53995185G>T	uc002qbu.2	+	4	1827	c.1699G>T	c.(1699-1701)GCA>TCA	p.A567S	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	567	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		AGCACACCTTGCACGTCACCA	0.378													T	53995185	T	T	53995185	3	4	108	1	0	0	0	0	1	0	0	0	18172	1319	46	5	1709	5	ZNF813	19	53995185	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	12364392	53995185	5133798	59	7466											
NLRP5	126206	broad.mit.edu	37	chr19	56515184	56515184	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgtatcaagatggaaggagaCaaatcgctcaccttttccag	9	9	2	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr19:56515184C>A	uc002qmj.2	+	2	165	c.165C>A	c.(163-165)GAC>GAA	p.D55E	NLRP5_uc002qmi.2_Missense_Mutation_p.D55E	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	55						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGGAAGGAGACAAATCGCTCA	0.423													A	56515184	A	A	56515184	3	1	108	1	0	0	0	0	1	0	0	0	10480	477	17	5	171	5	NLRP5	19	56515184	Missense_Mutation	SNP	C	TCGA-06-6700-01A-12D-1845-08	2519999	56515184	2613799	60	7467											
PCK1	5105	broad.mit.edu	37	chr20	56139269	56139269	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaatggctttttcggtgtcGctcctgggacttcagtgaag	12	8	1	1			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr20:56139269G>A	uc002xyn.3	+	7	1169	c.1006G>A	c.(1006-1008)GCT>ACT	p.A336T	PCK1_uc010zzm.1_Missense_Mutation_p.A19T	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	336					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TTTCGGTGTCGCTCCTGGGAC	0.493													A	56139269	A	A	56139269	3	1	108	1	0	0	0	0	1	0	0	0	11581	1087	38	1	1028	1	PCK1	20	56139269	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08		56139269	6886251	61	7468											
SLC17A9	63910	broad.mit.edu	37	chr20	61588307	61588307	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggttgtgggcggccacctcGgggatcggtaactgcccatc	15	12	0	0			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chr20:61588307G>A	uc002yea.3	+	2	434	c.250G>A	c.(250-252)GGG>AGG	p.G84R	SLC17A9_uc002ydz.3_Missense_Mutation_p.G78R|SLC17A9_uc011aap.1_Missense_Mutation_p.G104R	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	84	Helical; (Potential).				exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						CGGCCACCTCGGGGATCGGTA	0.662													A	61588307	A	A	61588307	3	1	108	1	0	0	0	0	1	0	0	0	14424	1116	39	2	256	2	SLC17A9	20	61588307	Missense_Mutation	SNP	G	TCGA-06-6700-01A-12D-1845-08	5449038	61588307	1437213	62	7469											
FTHL17	53940	broad.mit.edu	37	chrX	31089936	31089936	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagttctccagggccacgtcGtcccggttgaagtagaaggc	13	11	1	2			TCGA-06-6700-01A-12D-1845-08	TCGA-06-6700-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6da42a38-94dd-49b7-8a03-df0f7174ca6f	a9cc39c8-e3c8-4642-ad0d-1f9a43f21baf	g.chrX:31089936G>A	uc004dcl.1	-	1	238	c.135C>T	c.(133-135)GAC>GAT	p.D45D		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	45	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0						GGGCCACGTCGTCCCGGTTGA	0.582													A	31089936	A	A	31089936	2	1	108	1	0	0	0	0	0	0	0	1	6083	1136	40	1		1	FTHL17	23	31089936	Silent	SNP	G	TCGA-06-6700-01A-12D-1845-08		31089936	124180624	63	7470											
EPHA10	284656	broad.mit.edu	37	chr1	38197144	38197144	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggcctcccaggatggcccCggggaagcggcccggatctg	17	14	1	0	rs77925917	by1000genomes	TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr1:38197144C>T	uc009vvi.2	-	7	1688	c.1602G>A	c.(1600-1602)CCG>CCA	p.P534P	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	534	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGGATGGCCCCGGGGAAGCGG	0.597													T	38197144	T	T	38197144	2	4	109	1	0	0	0	0	0	0	0	1	5166	639	23	2		2	EPHA10	1	38197144	Silent	SNP	C	TCGA-06-6701-01A-11D-1845-08		38197144	211053477	1	7471											
TMEM69	51249	broad.mit.edu	37	chr1	46159245	46159245	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttatggagccagtttcctaTctttcttgggtgggatcaga	11	8	3	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr1:46159245T>C	uc001cor.1	+	3	608	c.412T>C	c.(412-414)TCT>CCT	p.S138P		NM_016486	NP_057570	Q5SWH9	TMM69_HUMAN	transmembrane protein 69	138	Helical; (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CAGTTTCCTATCTTTCTTGGG	0.443													C	46159245	C	C	46159245	3	2	109	1	0	0	0	0	1	0	0	0	16195	1435	50	4	418	4	TMEM69	1	46159245	Missense_Mutation	SNP	T	TCGA-06-6701-01A-11D-1845-08	7962101	46159245	203091376	2	7472											
KIAA1324	57535	broad.mit.edu	37	chr1	109737164	109737164	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggagggccaagcttcacttCcaaagggctgaaatacttcc	10	11	1	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr1:109737164C>T	uc001dwq.2	+	16	2205	c.2069C>T	c.(2068-2070)TCC>TTC	p.S690F	KIAA1324_uc009wex.1_Missense_Mutation_p.S640F|KIAA1324_uc009wey.2_Missense_Mutation_p.S603F|KIAA1324_uc010ovg.1_Missense_Mutation_p.S588F|KIAA1324_uc001dwr.2_Missense_Mutation_p.S340F|KIAA1324_uc001dws.1_5'Flank|KIAA1324_uc009wez.1_5'Flank	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	690	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		AGCTTCACTTCCAAAGGGCTG	0.493													T	109737164	T	T	109737164	3	4	109	1	0	0	0	0	1	0	0	0	8223	855	30	3	2127	3	KIAA1324	1	109737164	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08	63577919	109737164	139513457	3	7473											
CEP170	9859	broad.mit.edu	37	chr1	243332957	243332957	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaaggaagaggtgcagaaaAttccattatcctttcttctt	7	7	2	2			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr1:243332957A>G	uc001hzs.2	-	12	2224	c.1816T>C	c.(1816-1818)TTT>CTT	p.F606L	CEP170_uc001hzt.2_Missense_Mutation_p.F508L|CEP170_uc001hzu.2_Missense_Mutation_p.F508L	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	606						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GGTGCAGAAAATTCCATTATC	0.294													G	243332957	G	G	243332957	3	3	109	1	0	0	0	0	1	0	0	0	3250	101	4	4	3004	4	CEP170	1	243332957	Missense_Mutation	SNP	A	TCGA-06-6701-01A-11D-1845-08	133595793	243332957	5917664	4	7474											
SERTAD2	9792	broad.mit.edu	37	chr2	64863336	64863336	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaaattcccaggcagagAgtccatcagttttgagtcat	8	9	3	2			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr2:64863336A>T	uc002sde.1	-	2	967	c.670T>A	c.(670-672)TCT>ACT	p.S224T		NM_014755	NP_055570	Q14140	SRTD2_HUMAN	SERTA domain containing 2	224					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus					0						CCAGGCAGAGAGTCCATCAGT	0.527													T	64863336	T	T	64863336	3	4	109	1	0	0	0	0	1	0	0	0	14121	304	11	5	278	5	SERTAD2	2	64863336	Missense_Mutation	SNP	A	TCGA-06-6701-01A-11D-1845-08		64863336	178336037	5	7475											
TTC31	64427	broad.mit.edu	37	chr2	74718780	74718780	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tccaagagaggagaggccccAgcagagtccaaaggtacagg	14	10	0	3			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr2:74718780A>T	uc002slt.2	+	8	880	c.857A>T	c.(856-858)CAG>CTG	p.Q286L	TTC31_uc002sls.2_Missense_Mutation_p.Q215L|TTC31_uc010yrv.1_Intron|TTC31_uc002slu.2_Missense_Mutation_p.Q142L	NM_022492	NP_071937	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	286							binding				0						GAGAGGCCCCAGCAGAGTCCA	0.597													T	74718780	T	T	74718780	3	4	109	1	0	0	0	0	1	0	0	0	16697	188	7	5	887	5	TTC31	2	74718780	Missense_Mutation	SNP	A	TCGA-06-6701-01A-11D-1845-08	9855444	74718780	168480593	6	7476											
IL18RAP	8807	broad.mit.edu	37	chr2	103067331	103067331	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaaggattttgatgctttcGtatcctatgcaaaatggagc	9	6	0	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr2:103067331G>A	uc002tbx.2	+	11	1718	c.1234G>A	c.(1234-1236)GTA>ATA	p.V412I	IL18RAP_uc010fiz.2_Missense_Mutation_p.V270I	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	412	TIR.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						TGATGCTTTCGTATCCTATGC	0.338													A	103067331	A	A	103067331	3	1	109	1	0	0	0	0	1	0	0	0	7648	1145	40	1	1268	1	IL18RAP	2	103067331	Missense_Mutation	SNP	G	TCGA-06-6701-01A-11D-1845-08	28348551	103067331	140132042	7	7477											
ZNF385B	151126	broad.mit.edu	37	chr2	180634432	180634432	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactggtcctcaggcctgtcGttctttatccccttttcttc	6	14	3	0	rs61747266	byFrequency	TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr2:180634432G>A	uc002unn.3	-	3	655	c.51C>T	c.(49-51)AAC>AAT	p.N17N		NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	17						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			CAGGCCTGTCGTTCTTTATCC	0.463													A	180634432	A	A	180634432	2	1	109	1	0	0	0	0	0	0	0	1	17874	1136	40	1		1	ZNF385B	2	180634432	Silent	SNP	G	TCGA-06-6701-01A-11D-1845-08	77567101	180634432	62564941	8	7478											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	109	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08	28478680	209113112	34086261	9	7479											
IRS1	3667	broad.mit.edu	37	chr2	227661259	227661259	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccactggtgacatgttcatGtagtcacctgtgcaaggtaa	10	10	2	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr2:227661259G>C	uc002voh.3	-	1	2248	c.2196C>G	c.(2194-2196)TAC>TAG	p.Y732*		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	732	YXXM motif 6.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		ACATGTTCATGTAGTCACCTG	0.597											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	227661259	C	C	227661259	4	2	109	1	0	0	0	0	0	1	0	0	7840	1372	48	5	1536	5	IRS1	2	227661259	Nonsense_Mutation	SNP	G	TCGA-06-6701-01A-11D-1845-08	18548147	227661259	15538114	10	7480											
RNF123	63891	broad.mit.edu	37	chr3	49735348	49735348	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcaactttggcaccatcCgctctaccacatgcgtgtac	7	15	1	0			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr3:49735348C>T	uc003cxh.2	+	6	459	c.373C>T	c.(373-375)CGC>TGC	p.R125C	RNF123_uc010hky.1_5'Flank|RNF123_uc003cxi.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	125	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		TGGCACCATCCGCTCTACCAC	0.557													T	49735348	T	T	49735348	3	4	109	1	0	0	0	0	1	0	0	0	13433	652	23	2	391	2	RNF123	3	49735348	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08		49735348	148287082	11	7481											
EPHA3	2042	broad.mit.edu	37	chr3	89462354	89462354	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaagaccctacccaagctgTtcatgagtttgccaaggaat	9	10	1	3			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr3:89462354T>C	uc003dqy.2	+	10	2051	c.1826T>C	c.(1825-1827)GTT>GCT	p.V609A	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	609	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ACCCAAGCTGTTCATGAGTTT	0.423										TSP Lung(6;0.00050)			C	89462354	C	C	89462354	3	2	109	1	0	0	0	0	1	0	0	0	5168	1725	60	4	1890	4	EPHA3	3	89462354	Missense_Mutation	SNP	T	TCGA-06-6701-01A-11D-1845-08	39727006	89462354	108560076	12	7482											
FRAS1	80144	broad.mit.edu	37	chr4	79429983	79429983	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccactggtctgtgtcaccccCtgcgaccctcatttccccag	7	19	3	0			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr4:79429983C>A	uc003hlb.2	+	63	10043	c.9603C>A	c.(9601-9603)CCC>CCA	p.P3201P	FRAS1_uc003hlc.1_Silent_p.P203P	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3196	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GTGTCACCCCCTGCGACCCTC	0.567													A	79429983	A	A	79429983	2	1	109	1	0	0	0	0	0	0	0	1	6042	668	24	5		5	FRAS1	4	79429983	Silent	SNP	C	TCGA-06-6701-01A-11D-1845-08		79429983	111724293	13	7483											
COPS4	51138	broad.mit.edu	37	chr4	83970319	83970319	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttttttttttttaaacaagTggtaaatgagaatgtcagtc	7	3	1	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr4:83970319T>G	uc003hoa.2	+	3	294	c.155T>G	c.(154-156)ATG>AGG	p.M52R	COPS4_uc003hob.2_Missense_Mutation_p.M52R|COPS4_uc010ijw.2_Missense_Mutation_p.M52R|COPS4_uc010ijx.2_Missense_Mutation_p.M52R	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	52					cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				TTTAAACAAGTGGTAAATGAG	0.318													G	83970319	G	G	83970319	3	3	109	1	0	0	0	0	1	0	0	0	3735	1710	59	5	165	5	COPS4	4	83970319	Missense_Mutation	SNP	T	TCGA-06-6701-01A-11D-1845-08	4540336	83970319	107183957	14	7484											
TAS2R1	50834	broad.mit.edu	37	chr5	9629276	9629276	+	Frame_Shift_Del	DEL	T	-	-													acttactgtggaggaggaacTtttttgcattttgtttcaat							TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr5:9629276delT	uc003jem.1	-	1	1188	c.869delA	c.(868-870)AAGfs	p.K290fs		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	290	Cytoplasmic (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						GAGGAGGAACTTTTTTGCATT	0.393													-	9629276	-	-	9629276	7	5	109	1	0	1	0	1	0	0	0	0	15562	1609	56	0	34	0	TAS2R1	5	9629276	Frame_Shift_Del	DEL	T	TCGA-06-6701-01A-11D-1845-08		9629276	171285984	15	7485											
RGNEF	64283	broad.mit.edu	37	chr5	73128199	73128199	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctaaaaaaatccaagccgcCctcgacattgcttgctgcag	7	14	0	0			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr5:73128199C>T	uc011csq.1	+	9	1072	c.1061C>T	c.(1060-1062)CCC>CTC	p.P354L	RGNEF_uc003kcx.2_Missense_Mutation_p.P354L|RGNEF_uc003kcy.1_Missense_Mutation_p.P354L|RGNEF_uc010izf.2_Missense_Mutation_p.P354L|RGNEF_uc011csr.1_Missense_Mutation_p.P41L	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	354					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		TCCAAGCCGCCCTCGACATTG	0.448													T	73128199	T	T	73128199	3	4	109	1	0	0	0	0	1	0	0	0	13283	623	22	3	1095	3	RGNEF	5	73128199	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08	63498923	73128199	107787061	16	7486											
ENC1	8507	broad.mit.edu	37	chr5	73931841	73931841	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcttggtgcactggtgtgcaTcagacagcagcagcatgccc	13	12	1	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr5:73931841T>C	uc003kdc.3	-	2	1601	c.470A>G	c.(469-471)GAT>GGT	p.D157G	ENC1_uc011css.1_Missense_Mutation_p.D84G	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	157					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		CTGGTGTGCATCAGACAGCAG	0.517													C	73931841	C	C	73931841	3	2	109	1	0	0	0	0	1	0	0	0	5113	1435	50	4	1303	4	ENC1	5	73931841	Missense_Mutation	SNP	T	TCGA-06-6701-01A-11D-1845-08	803642	73931841	106983419	17	7487											
PCDHGB4	8641	broad.mit.edu	37	chr5	140769114	140769114	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgttagtggacgaccgcaacGacaatgcgccacgggtgctg	14	11	0	0			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr5:140769114G>A	uc003lkc.1	+	1	1663	c.1663G>A	c.(1663-1665)GAC>AAC	p.D555N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.D555N	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	555	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACCGCAACGACAATGCGCC	0.672													A	140769114	A	A	140769114	3	1	109	1	0	0	0	0	1	0	0	0	11565	1058	37	2	1665	2	PCDHGB4	5	140769114	Missense_Mutation	SNP	G	TCGA-06-6701-01A-11D-1845-08	66837273	140769114	40146146	18	7488											
ELOVL2	54898	broad.mit.edu	37	chr6	10995345	10995345	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcgtttttttccgcaaaaCgaagaaaattgtgtccagga	8	8	0	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr6:10995345C>T	uc003mzp.3	-	5	561	c.400G>A	c.(400-402)GTT>ATT	p.V134I		NM_017770	NP_060240	Q9NXB9	ELOV2_HUMAN	elongation of very long chain fatty acids-like	134					fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Breast(50;0.0418)|Ovarian(93;0.0919)	all_hematologic(90;0.117)	Epithelial(50;0.176)			TTCCGCAAAACGAAGAAAATT	0.393													T	10995345	T	T	10995345	3	4	109	1	0	0	0	0	1	0	0	0	5074	536	19	1	506	1	ELOVL2	6	10995345	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08		10995345	160119722	19	7489											
ITPR3	3710	broad.mit.edu	37	chr6	33654271	33654271	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccccctgtgcaagtaccGcatggatctggtgctgcagc	12	14	1	0			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr6:33654271G>A	uc011drk.1	+	43	6173	c.5954G>A	c.(5953-5955)CGC>CAC	p.R1985H	ITPR3_uc003oey.2_Missense_Mutation_p.R72H	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1985	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TGCAAGTACCGCATGGATCTG	0.547													A	33654271	A	A	33654271	3	1	109	1	0	0	0	0	1	0	0	0	7922	1087	38	1	6124	1	ITPR3	6	33654271	Missense_Mutation	SNP	G	TCGA-06-6701-01A-11D-1845-08	22658926	33654271	137460796	20	7490											
SNAI2	6591	broad.mit.edu	37	chr8	49832679	49832679	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaaagttgaataggtcttaTtgcataaattgcactgaaac	7	5	1	2			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr8:49832679T>C	uc003xqp.2	-	2	565	c.401A>G	c.(400-402)AAT>AGT	p.N134S		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	134	C2H2-type 1.				canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.N134D(1)		ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				ATAGGTCTTATTGCATAAATT	0.438													C	49832679	C	C	49832679	3	2	109	1	0	0	0	0	1	0	0	0	14827	1493	52	4	413	4	SNAI2	8	49832679	Missense_Mutation	SNP	T	TCGA-06-6701-01A-11D-1845-08		49832679	96531343	21	7491											
ZFHX4	79776	broad.mit.edu	37	chr8	77617855	77617855	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ccaaagcatttctcctttatCatccagtgtgctaaaattta	4	10	2	0			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr8:77617855C>T	uc003yav.2	+	2	1919	c.1532C>T	c.(1531-1533)TCA>TTA	p.S511L	ZFHX4_uc003yat.1_Missense_Mutation_p.S511L|ZFHX4_uc003yau.1_Missense_Mutation_p.S511L|ZFHX4_uc003yaw.1_Missense_Mutation_p.S511L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	511						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCTCCTTTATCATCCAGTGTG	0.413										HNSCC(33;0.089)			T	77617855	T	T	77617855	3	4	109	1	0	0	0	0	1	0	0	0	17632	838	29	3	1534	3	ZFHX4	8	77617855	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08	27785176	77617855	68746167	22	7492			1	26		2	2	43	C		6.783428e-05
ZFHX4	79776	broad.mit.edu	37	chr8	77617897	77617897	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgaaaagggtacctcgtcctCctcggcgactgtttctgatg	11	11	1	2			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr8:77617897C>T	uc003yav.2	+	2	1961	c.1574C>T	c.(1573-1575)TCC>TTC	p.S525F	ZFHX4_uc003yat.1_Missense_Mutation_p.S525F|ZFHX4_uc003yau.1_Missense_Mutation_p.S525F|ZFHX4_uc003yaw.1_Missense_Mutation_p.S525F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	525	Poly-Ser.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACCTCGTCCTCCTCGGCGACT	0.433										HNSCC(33;0.089)			T	77617897	T	T	77617897	3	4	109	1	0	0	0	0	1	0	0	0	17632	855	30	3	1576	3	ZFHX4	8	77617897	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08	42	77617897	68746125	23	7493			1	26		2	2	43	C		6.783428e-05
NPDC1	56654	broad.mit.edu	37	chr9	139934426	139934426	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caccctgaggcactcaccggGgccaggcccgggcactcgta	13	17	1	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr9:139934426G>C	uc004ckt.2	-	8	1117	c.882C>G	c.(880-882)GCC>GCG	p.A294A	NPDC1_uc004ckr.2_Silent_p.A294A|NPDC1_uc004cks.2_Silent_p.A372A|NPDC1_uc004cku.2_Silent_p.A294A	NM_015392	NP_056207	Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and	294						integral to membrane					0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CACTCACCGGGGCCAGGCCCG	0.657													C	139934426	C	C	139934426	2	2	109	1	0	0	0	0	0	0	0	1	10573	1219	43	5		5	NPDC1	9	139934426	Silent	SNP	G	TCGA-06-6701-01A-11D-1845-08		139934426	1279005	24	7494											
OGDHL	55753	broad.mit.edu	37	chr10	50955213	50955213	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttggtgacgcggttgatcctCtcatggtacatgcccaggtg	13	10	1	2			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr10:50955213C>G	uc001jie.2	-	9	1171	c.1029G>C	c.(1027-1029)GAG>GAC	p.E343D	OGDHL_uc009xog.2_Missense_Mutation_p.E370D|OGDHL_uc010qgt.1_Missense_Mutation_p.E286D|OGDHL_uc010qgu.1_Missense_Mutation_p.E134D|OGDHL_uc009xoh.2_Missense_Mutation_p.E134D	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	343					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGTTGATCCTCTCATGGTACA	0.587													G	50955213	G	G	50955213	3	3	109	1	0	0	0	0	1	0	0	0	10840	912	32	5	2063	5	OGDHL	10	50955213	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08		50955213	84579534	25	7495											
ENTPD1	953	broad.mit.edu	37	chr10	97607463	97607463	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccactccagggggattttggGgtaagtttgtgaaatgatga	14	5	0	3			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr10:97607463G>A	uc001klh.3	+	7	1398	c.1074G>A	c.(1072-1074)GGG>GGA	p.G358G	ENTPD1_uc001kli.3_Silent_p.G365G|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Silent_p.G370G|ENTPD1_uc010qok.1_Silent_p.G250G|ENTPD1_uc010qol.1_Silent_p.G250G|ENTPD1_uc010qom.1_Silent_p.G317G|ENTPD1_uc010qon.1_Silent_p.G220G|ENTPD1_uc009xva.2_Silent_p.G220G|ENTPD1_uc009xuz.2_RNA	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	358	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		GGGATTTTGGGGTAAGTTTGT	0.303													A	97607463	A	A	97607463	2	1	109	1	0	0	0	0	0	0	0	1	5138	1246	43	3		3	ENTPD1	10	97607463	Silent	SNP	G	TCGA-06-6701-01A-11D-1845-08	46652250	97607463	37927284	26	7496											
ACADSB	36	broad.mit.edu	37	chr10	124813243	124813243	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaggagcttccaacatccagTtgaacaccattgcaaagcat	7	11	0	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr10:124813243T>C	uc001lhb.2	+	11	1378	c.1261T>C	c.(1261-1263)TTG>CTG	p.L421L	ACADSB_uc010qub.1_Silent_p.L319L	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	421					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	CAACATCCAGTTGAACACCAT	0.393													C	124813243	C	C	124813243	2	2	109	1	0	0	0	0	0	0	0	1	115	1722	60	4		4	ACADSB	10	124813243	Silent	SNP	T	TCGA-06-6701-01A-11D-1845-08	27205780	124813243	10721504	27	7497											
MMP26	56547	broad.mit.edu	37	chr11	5012728	5012728	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggtcagcttcagacactggTaaatgccttgtttggtggga	13	7	2	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr11:5012728T>C	uc001lzv.2	+	4	613	c.595_splice	c.e4+2	p.G199_splice		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein						collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CAGACACTGGTAAATGCCTTG	0.483													C	5012728	C	C	5012728	5	2	109	1	0	0	0	0	0	0	1	0	9663	1652	57	4	611	4	MMP26	11	5012728	Splice_Site	SNP	T	TCGA-06-6701-01A-11D-1845-08		5012728	129993788	28	7498											
GTF2H1	2965	broad.mit.edu	37	chr11	18369162	18369162	+	Frame_Shift_Del	DEL	G	-	-													gcatttcctctgtgccatctGcttccaattctaaatccata							TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr11:18369162delG	uc001moi.2	+	9	1559	c.865delG	c.(865-867)GCTfs	p.A289fs	GTF2H1_uc001moh.2_Frame_Shift_Del_p.A289fs|GTF2H1_uc009yhm.2_Frame_Shift_Del_p.A173fs|GTF2H1_uc001moj.2_5'UTR	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	289					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						TGTGCCATCTGCTTCCAATTC	0.368								NER					-	18369162	-	-	18369162	7	5	109	1	0	1	0	1	0	0	0	0	6860	1319	46	0	891	0	GTF2H1	11	18369162	Frame_Shift_Del	DEL	G	TCGA-06-6701-01A-11D-1845-08	13356434	18369162	116637354	29	7499											
DDN	23109	broad.mit.edu	37	chr12	49391285	49391285	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggatcgtatcactacgcaCgtggcgtcaatgacaaagac	11	10	2	2			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr12:49391285C>T	uc001rsv.1	-	2	1392	c.1374G>A	c.(1372-1374)ACG>ACA	p.T458T	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	458	Interaction with CD2AP and NPHS1 (By similarity).					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						TCACTACGCACGTGGCGTCAA	0.642													T	49391285	T	T	49391285	2	4	109	1	0	0	0	0	0	0	0	1	4333	523	19	1		1	DDN	12	49391285	Silent	SNP	C	TCGA-06-6701-01A-11D-1845-08		49391285	84460610	30	7500											
TSPAN19	144448	broad.mit.edu	37	chr12	85411285	85411285	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acaaaaccattttcttaaagTtgactttgtgcaagaacatg	6	7	1	2			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr12:85411285T>A	uc009zsj.2	-	7	645	c.544A>T	c.(544-546)ACT>TCT	p.T182S		NM_001100917	NP_001094387	P0C672	TSN19_HUMAN	tetraspanin 19	182						integral to membrane				ovary(1)	1						TTTCTTAAAGTTGACTTTGTG	0.343													A	85411285	A	A	85411285	3	1	109	1	0	0	0	0	1	0	0	0	16640	1725	60	5	214	5	TSPAN19	12	85411285	Missense_Mutation	SNP	T	TCGA-06-6701-01A-11D-1845-08	36020000	85411285	48440610	31	7501											
GPR109B	8843	broad.mit.edu	37	chr12	123200903	123200903	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtggggatggaccacccGgaaatacctgtctaccgcca	13	12	1	0			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr12:123200903G>A	uc001ucy.3	-	1	537	c.382C>T	c.(382-384)CGG>TGG	p.R128W	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	128	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	TGGACCACCCGGAAATACCTG	0.562													A	123200903	A	A	123200903	3	1	109	1	0	0	0	0	1	0	0	0	6626	1115	39	2	785	2	GPR109B	12	123200903	Missense_Mutation	SNP	G	TCGA-06-6701-01A-11D-1845-08	37789618	123200903	10650992	32	7502											
TRPC4	7223	broad.mit.edu	37	chr13	38320377	38320377	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggccaaggccttgtagatGttgagtctggagcgtgagtg	16	7	1	3			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr13:38320377G>A	uc001uws.2	-	3	829	c.594C>T	c.(592-594)AAC>AAT	p.N198N	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Silent_p.N198N|TRPC4_uc010tey.1_Silent_p.N198N|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Silent_p.N198N|TRPC4_uc010aby.2_Silent_p.N198N	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	198	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CCTTGTAGATGTTGAGTCTGG	0.532													A	38320377	A	A	38320377	2	1	109	1	0	0	0	0	0	0	0	1	16577	1368	48	3		3	TRPC4	13	38320377	Silent	SNP	G	TCGA-06-6701-01A-11D-1845-08		38320377	76849501	33	7503											
CDH24	64403	broad.mit.edu	37	chr14	23524268	23524268	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcagagctggggtgctcacCgacattggacatctcgggca	13	11	3	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr14:23524268C>T	uc001wil.2	-	3	756	c.496G>A	c.(496-498)GGG>AGG	p.G166R	CDH24_uc010akf.2_Missense_Mutation_p.G166R|CDH24_uc001win.3_Missense_Mutation_p.G166R	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	166	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GGGTGCTCACCGACATTGGAC	0.552											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	23524268	T	T	23524268	3	4	109	1	0	0	0	0	1	0	0	0	3109	666	23	2	2007	2	CDH24	14	23524268	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08		23524268	83825272	34	7504											
ZNF710	374655	broad.mit.edu	37	chr15	90610834	90610834	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccctggtgcagagcagcgcCgtcaagatgatcgacctcag	13	13	2	3			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr15:90610834C>T	uc002bov.1	+	2	588	c.465C>T	c.(463-465)GCC>GCT	p.A155A		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			AGAGCAGCGCCGTCAAGATGA	0.687													T	90610834	T	T	90610834	2	4	109	1	0	0	0	0	0	0	0	1	18112	639	23	2		2	ZNF710	15	90610834	Silent	SNP	C	TCGA-06-6701-01A-11D-1845-08		90610834	11920558	35	7505											
WDR90	197335	broad.mit.edu	37	chr16	703624	703624	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggacttccagaccgggcggTgcttgtgcctgttccggagc	16	12	0	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr16:703624T>G	uc002cii.1	+	12	1387	c.1333T>G	c.(1333-1335)TGC>GGC	p.C445G	WDR90_uc002cig.1_Missense_Mutation_p.C445G|WDR90_uc002cih.1_Missense_Mutation_p.C446G|WDR90_uc002cij.1_RNA|WDR90_uc002cik.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	445	WD 1.									ovary(1)	1		Hepatocellular(780;0.0218)				GACCGGGCGGTGCTTGTGCCT	0.657													G	703624	G	G	703624	3	3	109	1	0	0	0	0	1	0	0	0	17334	1696	59	5	1379	5	WDR90	16	703624	Missense_Mutation	SNP	T	TCGA-06-6701-01A-11D-1845-08		703624	89651129	36	7506											
IGFALS	3483	broad.mit.edu	37	chr16	1842222	1842222	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggactccatcaggcaggcgcGtgaggttcctggagctgcag	16	11	1	1	rs145465654		TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr16:1842222G>A	uc002cmy.2	-	2	278	c.197C>T	c.(196-198)ACG>ATG	p.T66M	IGFALS_uc010uvn.1_Missense_Mutation_p.T104M|IGFALS_uc010uvo.1_Translation_Start_Site	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	66	LRRNT.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0						AGGCAGGCGCGTGAGGTTCCT	0.692													A	1842222	A	A	1842222	3	1	109	1	0	0	0	0	1	0	0	0	7577	1145	40	1	1624	1	IGFALS	16	1842222	Missense_Mutation	SNP	G	TCGA-06-6701-01A-11D-1845-08	1138598	1842222	88512531	37	7507											
A2BP1	54715	broad.mit.edu	37	chr16	7568147	7568148	+	Splice_Site	INS	-	G	G													tgcacctttttgatttttcaINSgggtaatcaggaagcagccg							TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr16:7568147_7568148insG	uc002cys.2	+	5	1016	c.28_splice	c.e5-1	p.G10_splice	A2BP1_uc010buf.1_Splice_Site_p.G10_splice|A2BP1_uc002cyr.1_Splice_Site_p.G10_splice|A2BP1_uc002cyt.2_Splice_Site_p.G10_splice|A2BP1_uc010uxz.1_Splice_Site_p.G53_splice|A2BP1_uc010uya.1_Splice_Site_p.G46_splice|A2BP1_uc002cyv.1_Splice_Site_p.G10_splice|A2BP1_uc010uyb.1_Splice_Site_p.G10_splice|A2BP1_uc002cyw.2_Splice_Site_p.G30_splice|A2BP1_uc002cyy.2_Splice_Site_p.G30_splice|A2BP1_uc002cyx.2_Splice_Site_p.G30_splice|A2BP1_uc010uyc.1_Splice_Site_p.G30_splice	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4						mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TTGATTTTTCAGGGTAATCAGG	0.574													G	7568148	G	G	7568147	8	5	109	1	0	1	1	0	0	0	1	0	3	202	7	0	123	0	A2BP1	16	7568147	Splice_Site	INS	-	TCGA-06-6701-01A-11D-1845-08	5725925	7568147	82786606	38	7508											
TP53	7157	broad.mit.edu	37	chr17	7577096	7577097	+	Missense_Mutation	DNP	TC	GG	GG													tctcttcctctgtgcgccggTctctcccaggacaggcacaa							TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr17:7577096_7577097TC>GG	uc002gim.2	-	8	1035_1036	c.841_842GA>CC	c.(841-843)GAC>CCC	p.D281P	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.D281P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.D149P|TP53_uc010cng.1_Missense_Mutation_p.D149P|TP53_uc002gii.1_Missense_Mutation_p.D149P|TP53_uc010cnh.1_Missense_Mutation_p.D281P|TP53_uc010cni.1_Missense_Mutation_p.D281P|TP53_uc002gij.2_Missense_Mutation_p.D281P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	281	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		D -> Y (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> V (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|D -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|D -> G (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|D -> A (in sporadic cancers; somatic mutation).|D -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.D281E(25)|p.D281H(19)|p.D281N(18)|p.D281G(10)|p.0?(7)|p.D281Y(6)|p.D281D(5)|p.D281V(3)|p.D281fs*63(2)|p.?(2)|p.R280_D281delRD(2)|p.D281A(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.D281R(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTGCGCCGGTCTCTCCCAGGA	0.55		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			GG	7577097	GG	GG	7577096	3	3	109	1	0	0	0	0	1	0	0	0	16378	1667	58	5	444	5	TP53	17	7577096	Missense_Mutation	DNP	TC	TCGA-06-6701-01A-11D-1845-08		7577096	73618114	39	7509											
DHRS7B	25979	broad.mit.edu	37	chr17	21094331	21094333	+	In_Frame_Del	DEL	GAA	-	-													gatgttcttgctgctgtgggGaagaagaagaaagatgtgat							TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr17:21094331_21094333delGAA	uc002gyo.2	+	7	870_872	c.843_845delGAA	c.(841-846)GGGAAG>GGG	p.K285del		NM_015510	NP_056325	Q6IAN0	DRS7B_HUMAN	dehydrogenase/reductase (SDR family) member 7B	285	Peroxisomal (Potential).					integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			pancreas(1)	1						CTGCTGTGGGGAAGAAGAAGAAA	0.507													-	21094333	-	-	21094331	7	5	109	1	0	1	0	1	0	0	0	0	4496	1161	41	0	869	0	DHRS7B	17	21094331	In_Frame_Del	DEL	GAA	TCGA-06-6701-01A-11D-1845-08	13517235	21094331	60100879	40	7510											
FOXN1	8456	broad.mit.edu	37	chr17	26851529	26851529	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtctacccagaagcatgcCggcttcagctgctcgtcatt	9	14	3	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr17:26851529C>T	uc010crm.2	+	3	330	c.132C>T	c.(130-132)GCC>GCT	p.A44A	FOXN1_uc002hbj.2_Silent_p.A44A	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	44					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					AGAAGCATGCCGGCTTCAGCT	0.637													T	26851529	T	T	26851529	2	4	109	1	0	0	0	0	0	0	0	1	6019	639	23	2		2	FOXN1	17	26851529	Silent	SNP	C	TCGA-06-6701-01A-11D-1845-08	5757198	26851529	54343681	41	7511											
ANKRD13B	124930	broad.mit.edu	37	chr17	27939701	27939701	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgcgagatctccccagcGttgttcgaggccccgcgcgg	15	15	1	1			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr17:27939701G>A	uc002hei.2	+	13	1556	c.1443G>A	c.(1441-1443)GCG>GCA	p.A481A	ANKRD13B_uc002heh.2_Silent_p.A349A|ANKRD13B_uc002hej.2_RNA|ANKRD13B_uc002hek.2_5'UTR	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	481											0						TCTCCCCAGCGTTGTTCGAGG	0.751													A	27939701	A	A	27939701	2	1	109	1	0	0	0	0	0	0	0	1	642	1132	40	1		1	ANKRD13B	17	27939701	Silent	SNP	G	TCGA-06-6701-01A-11D-1845-08	1088172	27939701	53255509	42	7512											
C18orf22	79863	broad.mit.edu	37	chr18	77794598	77794598	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	caggctgcgagcggggacttCactgctctgctgtctcctgc	13	14	3	0			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr18:77794598C>T	uc002lns.2	+	1	241	c.103C>T	c.(103-105)CAC>TAC	p.H35Y	TXNL4A_uc010drg.2_5'Flank|C18orf22_uc010drh.2_Missense_Mutation_p.H35Y|C18orf22_uc010dri.1_RNA	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	35					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		GCGGGGACTTCACTGCTCTGC	0.662													T	77794598	T	T	77794598	3	4	109	1	0	0	0	0	1	0	0	0	1898	826	29	3	105	3	C18orf22	18	77794598	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08		77794598	282650	43	7513											
MAST1	22983	broad.mit.edu	37	chr19	12977473	12977473	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tacccgctccccagcccgctCagacaggtatcaccacgtga	8	18	2	2			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr19:12977473C>T	uc002mvm.2	+	18	2164	c.2036C>T	c.(2035-2037)TCA>TTA	p.S679L		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	679	AGC-kinase C-terminal.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CCAGCCCGCTCAGACAGGTAT	0.597													T	12977473	T	T	12977473	3	4	109	1	0	0	0	0	1	0	0	0	9324	838	29	3	2106	3	MAST1	19	12977473	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08		12977473	46151510	44	7514											
CYP4F8	11283	broad.mit.edu	37	chr19	15734860	15734860	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagaacgctgccggcaggaGgtgcaagagcttctgaagga	15	9	1	3			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr19:15734860G>A	uc002nbi.2	+	11	1135	c.1071G>A	c.(1069-1071)GAG>GAA	p.E357E	CYP4F8_uc010xoj.1_Silent_p.E169E	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	357					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						GCCGGCAGGAGGTGCAAGAGC	0.582													A	15734860	A	A	15734860	2	1	109	1	0	0	0	0	0	0	0	1	4191	991	35	3		3	CYP4F8	19	15734860	Silent	SNP	G	TCGA-06-6701-01A-11D-1845-08	2757387	15734860	43394123	45	7515											
PSG6	5675	broad.mit.edu	37	chr19	43420415	43420415	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attggaatatactgtttctcGtccactgtaggcaggcccat	9	10	1	0	rs112289603	byFrequency	TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr19:43420415G>A	uc002ovj.1	-	2	341	c.289C>T	c.(289-291)CGA>TGA	p.R97*	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ovf.1_Nonsense_Mutation_p.R97*|PSG6_uc002ovg.1_Nonsense_Mutation_p.R97*	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	97	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				ACTGTTTCTCGTCCACTGTAG	0.458													A	43420415	A	A	43420415	4	1	109	1	0	0	0	0	0	1	0	0	12659	1153	40	1	1077	1	PSG6	19	43420415	Nonsense_Mutation	SNP	G	TCGA-06-6701-01A-11D-1845-08	27685555	43420415	15708568	46	7516											
DKKL1	27120	broad.mit.edu	37	chr19	49867855	49867855	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcctccccacctgccccCgcaaggcggcatctgctggt	10	19	1	0			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr19:49867855C>T	uc002pnk.2	+	2	241	c.27C>T	c.(25-27)CCC>CCT	p.P9P	TEAD2_uc002pni.2_5'Flank|TEAD2_uc002pnj.2_5'Flank|TEAD2_uc010yao.1_5'Flank|TEAD2_uc010emw.2_5'Flank	NM_014419	NP_055234	Q9UK85	DKKL1_HUMAN	dickkopf-like 1 precursor	9					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity				0		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		CACCTGCCCCCGCAAGGCGGC	0.677													T	49867855	T	T	49867855	2	4	109	1	0	0	0	0	0	0	0	1	4548	639	23	2		2	DKKL1	19	49867855	Silent	SNP	C	TCGA-06-6701-01A-11D-1845-08	6447440	49867855	9261128	47	7517											
APOBEC3G	60489	broad.mit.edu	37	chr22	39479797	39479797	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaaccttgggtcagaggaCggcatgagacttacctgtgt	13	8	1	3			TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chr22:39479797C>T	uc003awx.2	+	5	985	c.643C>T	c.(643-645)CGG>TGG	p.R215W	APOBEC3G_uc003awy.2_Missense_Mutation_p.R148W	NM_021822	NP_068594	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	215					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2	Melanoma(58;0.04)					GGTCAGAGGACGGCATGAGAC	0.522													T	39479797	T	T	39479797	3	4	109	1	0	0	0	0	1	0	0	0	794	527	19	1	661	1	APOBEC3G	22	39479797	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08		39479797	11824769	48	7518											
CSF2RA	1438	broad.mit.edu	37	chrX	1413266	1413266	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccgtacgttgcaacacgaCgcactgcctcgtacggtgga	11	14	0	0	rs149974131	byFrequency	TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chrX:1413266C>T	uc010nct.2	+	9	1014	c.692C>T	c.(691-693)ACG>ATG	p.T231M	CSF2RA_uc011mhb.1_Missense_Mutation_p.T231M|CSF2RA_uc004cpq.2_Intron|CSF2RA_uc004cpn.2_Missense_Mutation_p.T231M|CSF2RA_uc004cpo.2_Missense_Mutation_p.T231M|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Missense_Mutation_p.T98M|CSF2RA_uc004cpp.2_Missense_Mutation_p.T231M|CSF2RA_uc010ncv.2_Missense_Mutation_p.T231M|CSF2RA_uc004cpr.2_Missense_Mutation_p.T231M	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	231	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TGCAACACGACGCACTGCCTC	0.572													T	1413266	T	T	1413266	3	4	109	1	0	0	0	0	1	0	0	0	3934	536	19	1	714	1	CSF2RA	23	1413266	Missense_Mutation	SNP	C	TCGA-06-6701-01A-11D-1845-08		1413266	153857294	49	7519											
ATRX	546	broad.mit.edu	37	chrX	76888787	76888792	+	In_Frame_Del	DEL	ATGATC	-	-													ttctatacatctcatagcctAtgatcataacaccaccatct							TCGA-06-6701-01A-11D-1845-08	TCGA-06-6701-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fad178f1-385b-4f94-bd29-567c1aa0a8fc	a0818f1a-6f38-46bb-8d45-5b236a4d25ed	g.chrX:76888787_76888792delATGATC	uc004ecp.3	-	19	5269_5274	c.5037_5042delGATCAT	c.(5035-5043)ATGATCATA>ATA	p.MI1679del	ATRX_uc004ecq.3_In_Frame_Del_p.MI1641del|ATRX_uc004eco.3_In_Frame_Del_p.MI1464del	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1679_1680	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CTCATAGCCTATGATCATAACACCAC	0.398			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						-	76888792	-	-	76888787	7	5	109	1	0	1	0	1	0	0	0	0	1208	449	16	0	2504	0	ATRX	23	76888787	In_Frame_Del	DEL	ATGATC	TCGA-06-6701-01A-11D-1845-08	75475521	76888787	78381773	50	7520											
CMPK1	51727	broad.mit.edu	37	chr1	47838725	47838725	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcaaggatggaacaagacCatggatgggaaggcagatgt	14	6	1	2			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr1:47838725C>T	uc001cri.2	+	3	566	c.417C>T	c.(415-417)ACC>ACT	p.T139T	CMPK1_uc010omp.1_Silent_p.T90T|CMPK1_uc010omq.1_RNA	NM_016308	NP_057392	P30085	KCY_HUMAN	UMP-CMP kinase 1 isoform a	107					nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleus	ATP binding|cytidylate kinase activity|nucleoside phosphate kinase activity|uridine kinase activity			ovary(1)	1					Gemcitabine(DB00441)	GGAACAAGACCATGGATGGGA	0.388													T	47838725	T	T	47838725	2	4	110	1	0	0	0	0	0	0	0	1	3580	581	21	3		3	CMPK1	1	47838725	Silent	SNP	C	TCGA-08-0386-01A-01D-1492-08		47838725	201411896	1	7521											
DDAH1	23576	broad.mit.edu	37	chr1	85790448	85790448	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactttctggatactcttccGgggttcggtgcagcaagacg	12	11	2	1			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr1:85790448G>A	uc001dlb.2	-	5	877	c.716C>T	c.(715-717)CCG>CTG	p.P239L	DDAH1_uc001dlc.2_Missense_Mutation_p.P136L|uc001dla.1_Intron|DDAH1_uc010osb.1_Missense_Mutation_p.P139L|DDAH1_uc009wco.2_Missense_Mutation_p.P136L	NM_012137	NP_036269	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	239					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding				0				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	ATACTCTTCCGGGGTTCGGTG	0.473													A	85790448	A	A	85790448	3	1	110	1	0	0	0	0	1	0	0	0	4321	1116	39	2	149	2	DDAH1	1	85790448	Missense_Mutation	SNP	G	TCGA-08-0386-01A-01D-1492-08	37951723	85790448	163460173	2	7522											
PKN2	5586	broad.mit.edu	37	chr1	89294277	89294277	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagattggtggggccttggcGtgcttatatatgaaatgctt	13	5	0	2			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr1:89294277G>A	uc001dmn.2	+	19	2875	c.2533G>A	c.(2533-2535)GTG>ATG	p.V845M	PKN2_uc010osp.1_Missense_Mutation_p.V829M|PKN2_uc010osq.1_Missense_Mutation_p.V688M|PKN2_uc009wcv.2_Missense_Mutation_p.V797M|PKN2_uc010osr.1_Missense_Mutation_p.V510M	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	845	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GGGCCTTGGCGTGCTTATATA	0.383													A	89294277	A	A	89294277	3	1	110	1	0	0	0	0	1	0	0	0	11980	1145	40	1	2607	1	PKN2	1	89294277	Missense_Mutation	SNP	G	TCGA-08-0386-01A-01D-1492-08	3503829	89294277	159956344	3	7523											
OR14C36	127066	broad.mit.edu	37	chr1	248512862	248512862	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtgtacctcaggccacctgcGatacctgcagccacccagga	10	16	1	0	rs143199703		TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr1:248512862G>A	uc010pzl.1	+	1	786	c.786G>A	c.(784-786)GCG>GCA	p.A262A		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A262A(1)		ovary(1)|central_nervous_system(1)|skin(1)	3						GGCCACCTGCGATACCTGCAG	0.463													A	248512862	A	A	248512862	2	1	110	1	0	0	0	0	0	0	0	1	10946	1045	37	2		2	OR14C36	1	248512862	Silent	SNP	G	TCGA-08-0386-01A-01D-1492-08	159218585	248512862	737759	4	7524											
PLCD1	5333	broad.mit.edu	37	chr3	38051499	38051499	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	catcacgcgctgctgctccaGtgtgcagtggttctccaggg	13	13	2	0			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr3:38051499G>C	uc003chn.2	-	8	1307	c.1183C>G	c.(1183-1185)CTG>GTG	p.L395V	PLCD1_uc003chm.2_Missense_Mutation_p.L416V	NM_006225	NP_006216	P51178	PLCD1_HUMAN	phospholipase C, delta 1 isoform 2	395	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		TGCTGCTCCAGTGTGCAGTGG	0.647													C	38051499	C	C	38051499	3	2	110	1	0	0	0	0	1	0	0	0	12031	1020	36	5	1119	5	PLCD1	3	38051499	Missense_Mutation	SNP	G	TCGA-08-0386-01A-01D-1492-08		38051499	159970931	5	7525											
MTMR12	54545	broad.mit.edu	37	chr5	32230234	32230234	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gactttgatttcgggcccctCgatatgcggtaacaacaaac	9	11	0	1			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr5:32230234C>T	uc003jhq.2	-	16	2064	c.1894G>A	c.(1894-1896)GAG>AAG	p.E632K	MTMR12_uc010iuk.2_Missense_Mutation_p.E578K|MTMR12_uc010iul.2_Missense_Mutation_p.E522K	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	632	Myotubularin phosphatase.					cytoplasm	phosphatase activity			ovary(1)	1						TCGGGCCCCTCGATATGCGGT	0.493													T	32230234	T	T	32230234	3	4	110	1	0	0	0	0	1	0	0	0	9941	893	31	2	353	2	MTMR12	5	32230234	Missense_Mutation	SNP	C	TCGA-08-0386-01A-01D-1492-08		32230234	148685026	6	7526											
PHF1	5252	broad.mit.edu	37	chr6	33380059	33380059	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatggcgcagcccccccggCtgagccgctctggtgcctcc	12	19	1	1			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr6:33380059C>T	uc003oeh.2	+	2	255	c.19C>T	c.(19-21)CTG>TTG	p.L7L	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Silent_p.L7L|PHF1_uc010jux.2_5'UTR	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	7					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				GCCCCCCCGGCTGAGCCGCTC	0.592													T	33380059	T	T	33380059	2	4	110	1	0	0	0	0	0	0	0	1	11820	796	28	3		3	PHF1	6	33380059	Silent	SNP	C	TCGA-08-0386-01A-01D-1492-08		33380059	137735008	7	7527											
COL21A1	81578	broad.mit.edu	37	chr6	56044496	56044496	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctaagttcggcatcttctgTttctgaaccaacaccaatag	6	11	4	1			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr6:56044496T>C	uc003pcs.2	-	3	752	c.520A>G	c.(520-522)ACA>GCA	p.T174A	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.T174A|COL21A1_uc003pcu.1_Missense_Mutation_p.T174A	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	174	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GCATCTTCTGTTTCTGAACCA	0.398													C	56044496	C	C	56044496	3	2	110	1	0	0	0	0	1	0	0	0	3680	1725	60	4	2465	4	COL21A1	6	56044496	Missense_Mutation	SNP	T	TCGA-08-0386-01A-01D-1492-08	22664437	56044496	115070571	8	7528											
CRY2	1408	broad.mit.edu	37	chr11	45891983	45891983	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaagtgcatcattggtgtGgactacccacggcccatcgt	11	13	1	0			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr11:45891983G>A	uc010rgn.1	+	9	1534	c.1512G>A	c.(1510-1512)GTG>GTA	p.V504V	CRY2_uc009ykw.2_Silent_p.V422V|CRY2_uc010rgo.1_Silent_p.V226V	NM_021117	NP_066940	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like) isoform 1	483	FAD-binding.|Required for inhibition of CLOCK-ARNTL- mediated transcription (By similarity).				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			central_nervous_system(1)	1						TCATTGGTGTGGACTACCCAC	0.532													A	45891983	A	A	45891983	2	1	110	1	0	0	0	0	0	0	0	1	3904	1335	47	3		3	CRY2	11	45891983	Silent	SNP	G	TCGA-08-0386-01A-01D-1492-08		45891983	89114533	9	7529											
P2RX2	22953	broad.mit.edu	37	chr12	133197851	133197853	+	In_Frame_Del	DEL	TAC	-	-													cccattgcaggtttgccaaaTactacaagatcaatggcacc							TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr12:133197851_133197853delTAC	uc001ukj.1	+	9	916_918	c.916_918delTAC	c.(916-918)TACdel	p.Y307del	P2RX2_uc001uki.1_In_Frame_Del_p.Y307del|P2RX2_uc001ukk.1_In_Frame_Del_p.Y307del|P2RX2_uc001ukl.1_In_Frame_Del_p.Y283del|P2RX2_uc001ukm.1_In_Frame_Del_p.Y235del|P2RX2_uc001ukn.1_In_Frame_Del_p.Y215del|P2RX2_uc009zyt.1_In_Frame_Del_p.Y307del|P2RX2_uc001uko.1_In_Frame_Del_p.Y273del	NM_170682	NP_733782	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X2 isoform A	307	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		GTTTGCCAAATACTACAAGATCA	0.606													-	133197853	-	-	133197851	7	5	110	1	0	1	0	1	0	0	0	0	11340	1406	49	0	950	0	P2RX2	12	133197851	In_Frame_Del	DEL	TAC	TCGA-08-0386-01A-01D-1492-08		133197851	654044	10	7530											
RIPK3	11035	broad.mit.edu	37	chr14	24808471	24808471	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcgataaccccttctaggCgcagcacgaattcgttatcc	7	14	2	0			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr14:24808471C>T	uc001wpb.2	-	3	431	c.221G>A	c.(220-222)CGC>CAC	p.R74H	RIPK3_uc001wpa.2_5'Flank|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_5'UTR|RIPK3_uc010toj.1_Missense_Mutation_p.R74H	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	74	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		CCCTTCTAGGCGCAGCACGAA	0.577													T	24808471	T	T	24808471	3	4	110	1	0	0	0	0	1	0	0	0	13382	768	27	1	1367	1	RIPK3	14	24808471	Missense_Mutation	SNP	C	TCGA-08-0386-01A-01D-1492-08		24808471	82541069	11	7531											
MYH1	4619	broad.mit.edu	37	chr17	10404048	10404048	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagttgatcttctagagcgcGgcacatcttttcaaggtttc	9	10	4	2			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr17:10404048G>A	uc002gmo.2	-	28	3854	c.3760C>T	c.(3760-3762)CGC>TGC	p.R1254C	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1254	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCTAGAGCGCGGCACATCTTT	0.448													A	10404048	A	A	10404048	3	1	110	1	0	0	0	0	1	0	0	0	10029	1116	39	2	2111	2	MYH1	17	10404048	Missense_Mutation	SNP	G	TCGA-08-0386-01A-01D-1492-08		10404048	70791162	12	7532											
ACTN4	81	broad.mit.edu	37	chr19	39205183	39205183	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagcacctgatggaggactaCgagaagctggccagcgacgt	15	10	0	2			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr19:39205183C>T	uc002oja.1	+	9	953	c.894C>T	c.(892-894)TAC>TAT	p.Y298Y	ACTN4_uc010egc.1_Silent_p.Y298Y	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	298	Spectrin 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGGAGGACTACGAGAAGCTGG	0.582													T	39205183	T	T	39205183	2	4	110	1	0	0	0	0	0	0	0	1	207	547	19	1		1	ACTN4	19	39205183	Silent	SNP	C	TCGA-08-0386-01A-01D-1492-08		39205183	19923800	13	7533											
SPHK2	56848	broad.mit.edu	37	chr19	49132916	49132916	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagccgctcacaccacgcggCgtgctcacagtggacgggga	15	14	2	0			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr19:49132916C>T	uc002pjr.2	+	7	2217	c.1851C>T	c.(1849-1851)GGC>GGT	p.G617G	SPHK2_uc010xzt.1_Silent_p.G558G|SPHK2_uc002pjs.2_Silent_p.G617G|SPHK2_uc002pjt.2_Silent_p.G411G|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Silent_p.G581G|SPHK2_uc002pjw.2_Silent_p.G679G	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	617					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CACCACGCGGCGTGCTCACAG	0.682													T	49132916	T	T	49132916	2	4	110	1	0	0	0	0	0	0	0	1	15046	755	27	1		1	SPHK2	19	49132916	Silent	SNP	C	TCGA-08-0386-01A-01D-1492-08	9927733	49132916	9996067	14	7534											
NLRP5	126206	broad.mit.edu	37	chr19	56539737	56539737	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttccaagaagtgtggcttcCgattaaccagaacctggact	9	11	0	2			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr19:56539737C>T	uc002qmj.2	+	7	2138	c.2138C>T	c.(2137-2139)CCG>CTG	p.P713L	NLRP5_uc002qmi.2_Missense_Mutation_p.P694L	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	713	LRR 1.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GTGTGGCTTCCGATTAACCAG	0.493													T	56539737	T	T	56539737	3	4	110	1	0	0	0	0	1	0	0	0	10480	652	23	2	2164	2	NLRP5	19	56539737	Missense_Mutation	SNP	C	TCGA-08-0386-01A-01D-1492-08	7406821	56539737	2589246	15	7535											
MZF1	7593	broad.mit.edu	37	chr19	59081801	59081801	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aggtgtcttgggcccaggctCtggagttggaggctcagttt	16	8	3	0			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr19:59081801C>G	uc002qto.2	-	3	1051	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	LOC100131691_uc002qtm.2_RNA|MZF1_uc002qtn.2_Missense_Mutation_p.E164Q|MZF1_uc010euu.1_Missense_Mutation_p.E205Q	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	164					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		GGCCCAGGCTCTGGAGTTGGA	0.582													G	59081801	G	G	59081801	3	3	110	1	0	0	0	0	1	0	0	0	10108	922	32	5	1730	5	MZF1	19	59081801	Missense_Mutation	SNP	C	TCGA-08-0386-01A-01D-1492-08	2542064	59081801	47182	16	7536											
MX1	4599	broad.mit.edu	37	chr21	42812934	42812934	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggcccaggaggtggaccccGagggagacaggaccatcggt	17	11	0	1			TCGA-08-0386-01A-01D-1492-08	TCGA-08-0386-11A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	90bf7f8f-4b8c-410f-afa6-2b439ec82f97	868f58c2-6cf1-4ae3-8a35-daf8ab5ad727	g.chr21:42812934G>A	uc002yzh.2	+	11	1659	c.712G>A	c.(712-714)GAG>AAG	p.E238K	MX1_uc002yzi.2_Missense_Mutation_p.E238K|MX1_uc010goq.2_Missense_Mutation_p.E238K	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	238					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GGTGGACCCCGAGGGAGACAG	0.632													A	42812934	A	A	42812934	3	1	110	1	0	0	0	0	1	0	0	0	9997	1059	37	2	730	2	MX1	21	42812934	Missense_Mutation	SNP	G	TCGA-08-0386-01A-01D-1492-08		42812934	5316961	17	7537											
IL28RA	163702	broad.mit.edu	37	chr1	24507335	24507335	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattctggggaggggccagaCggggcctccctgggggaaag	19	10	1	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:24507335C>T	uc001bis.2	-	2	81	c.68G>A	c.(67-69)CGT>CAT	p.R23H	IL28RA_uc001bir.2_Missense_Mutation_p.R23H|IL28RA_uc001bit.2_Missense_Mutation_p.R23H|IL28RA_uc001biu.2_Intron|IL28RA_uc001biv.2_Missense_Mutation_p.R23H	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	23	Extracellular (Potential).|Fibronectin type-III.				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)		AGGGGCCAGACGGGGCCTCCC	0.612													T	24507335	T	T	24507335	3	4	111	1	0	0	0	0	1	0	0	0	7684	536	19	1	1518	1	IL28RA	1	24507335	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08		24507335	224743286	1	7538											
C1orf177	163747	broad.mit.edu	37	chr1	55273597	55273597	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cccggctcctacaacctcaaAgacttcttagaacagctgcg	7	15	2	2			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:55273597A>T	uc001cyb.3	+	4	447	c.393A>T	c.(391-393)AAA>AAT	p.K131N	C1orf177_uc001cya.3_Missense_Mutation_p.K131N	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	131											0						ACAACCTCAAAGACTTCTTAG	0.547													T	55273597	T	T	55273597	3	4	111	1	0	0	0	0	1	0	0	0	2017	69	3	5	407	5	C1orf177	1	55273597	Missense_Mutation	SNP	A	TCGA-12-0615-01A-01D-1492-08	30766262	55273597	193977024	2	7539											
CELSR2	1952	broad.mit.edu	37	chr1	109801473	109801473	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgagaactacatgcgctgcGtgtcggtgctgcgcttcgac	14	12	0	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:109801473G>A	uc001dxa.3	+	2	3791	c.3730G>A	c.(3730-3732)GTG>ATG	p.V1244M		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1244	EGF-like 1; calcium-binding.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CATGCGCTGCGTGTCGGTGCT	0.692													A	109801473	A	A	109801473	3	1	111	1	0	0	0	0	1	0	0	0	3222	1145	40	1	3736	1	CELSR2	1	109801473	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	54527876	109801473	139449148	3	7540											
MOV10	4343	broad.mit.edu	37	chr1	113239252	113239252	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacctcttctgcttcccagGgctgatggaagtaaaggaaa	10	10	2	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:113239252G>A	uc001eck.2	+	14	2252	c.1982G>A	c.(1981-1983)GGG>GAG	p.G661E	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Missense_Mutation_p.G661E|MOV10_uc001ecm.2_Missense_Mutation_p.G601E	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	661					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TGCTTCCCAGGGCTGATGGAA	0.602													A	113239252	A	A	113239252	3	1	111	1	0	0	0	0	1	0	0	0	9718	1246	43	3	2032	3	MOV10	1	113239252	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	3437779	113239252	136011369	4	7541											
TCHHL1	126637	broad.mit.edu	37	chr1	152060548	152060548	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgccagtcagtgttgccccGttactgtcctcactggcata	9	14	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:152060548G>A	uc001ezo.1	-	2	137	c.72C>T	c.(70-72)AAC>AAT	p.N24N		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	24							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GTGTTGCCCCGTTACTGTCCT	0.473													A	152060548	A	A	152060548	2	1	111	1	0	0	0	0	0	0	0	1	15698	1136	40	1		1	TCHHL1	1	152060548	Silent	SNP	G	TCGA-12-0615-01A-01D-1492-08	38821296	152060548	97190073	5	7542											
FLG	2312	broad.mit.edu	37	chr1	152278705	152278705	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctcacactggatccctggCgcctgcttctcctggacccc	10	18	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:152278705C>T	uc001ezu.1	-	3	8693	c.8657G>A	c.(8656-8658)CGC>CAC	p.R2886H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2886	Ser-rich.|Filaggrin 17.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGATCCCTGGCGCCTGCTTCT	0.562									Ichthyosis				T	152278705	T	T	152278705	3	4	111	1	0	0	0	0	1	0	0	0	5922	768	27	1	3532	1	FLG	1	152278705	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	218157	152278705	96971916	6	7543											
KPRP	448834	broad.mit.edu	37	chr1	152733665	152733665	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tccctactgtggcccatccaGttacaaccaggggcaagaga	10	13	0	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:152733665G>T	uc001fal.1	+	2	1659	c.1601G>T	c.(1600-1602)AGT>ATT	p.S534I		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	534						cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCCATCCAGTTACAACCAG	0.582													T	152733665	T	T	152733665	3	4	111	1	0	0	0	0	1	0	0	0	8436	1029	36	5	1603	5	KPRP	1	152733665	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	454960	152733665	96516956	7	7544											
DDR2	4921	broad.mit.edu	37	chr1	162749984	162749984	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagaagagatacgaagaaccGtccctcattccaagaaatcc	8	11	1	4			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:162749984G>A	uc001gcf.2	+	19	2981	c.2516G>A	c.(2515-2517)CGT>CAT	p.R839H	DDR2_uc001gcg.2_Missense_Mutation_p.R839H|uc001gch.1_5'Flank	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	839	Cytoplasmic (Potential).|Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			ACGAAGAACCGTCCCTCATTC	0.498													A	162749984	A	A	162749984	3	1	111	1	0	0	0	0	1	0	0	0	4337	1145	40	1	2578	1	DDR2	1	162749984	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	10016319	162749984	86500637	8	7545											
KIFAP3	22920	broad.mit.edu	37	chr1	170007466	170007466	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttccaagttatcaggatttCgagcaagctgcaggatcaaa	9	9	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:170007466C>T	uc001ggv.2	-	5	753	c.482G>A	c.(481-483)CGA>CAA	p.R161Q	KIFAP3_uc010ply.1_Missense_Mutation_p.R83Q|KIFAP3_uc001ggw.1_Missense_Mutation_p.R117Q	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	161					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATCAGGATTTCGAGCAAGCTG	0.308													T	170007466	T	T	170007466	3	4	111	1	0	0	0	0	1	0	0	0	8311	884	31	2	1960	2	KIFAP3	1	170007466	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	7257482	170007466	79243155	9	7546											
FAM5B	57795	broad.mit.edu	37	chr1	177199272	177199272	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtttcaccaccaggtacaGgatttataggtaagtggggg	15	6	1	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr1:177199272G>A	uc001glf.2	+	2	572	c.260G>A	c.(259-261)AGG>AAG	p.R87K		NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	87						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						ACCAGGTACAGGATTTATAGG	0.612													A	177199272	A	A	177199272	3	1	111	1	0	0	0	0	1	0	0	0	5593	1000	35	3	262	3	FAM5B	1	177199272	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	7191806	177199272	72051349	10	7547											
ZAP70	7535	broad.mit.edu	37	chr2	98354224	98354224	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctccccctccccaggcccGctcagcagggaagtggccgc	11	19	2	0	rs150631046		TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr2:98354224G>A	uc002syd.1	+	12	1694	c.1487G>A	c.(1486-1488)CGC>CAC	p.R496H	ZAP70_uc002sye.1_Missense_Mutation_p.R386H|ZAP70_uc002syf.1_Missense_Mutation_p.R189H	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	496	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						CCCCAGGCCCGCTCAGCAGGG	0.627													A	98354224	A	A	98354224	3	1	111	1	0	0	0	0	1	0	0	0	17511	1087	38	1	1525	1	ZAP70	2	98354224	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08		98354224	144845149	11	7548											
SCN7A	6332	broad.mit.edu	37	chr2	167262324	167262324	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgatcttaaaagggttggcTaacaaaaaccctgattctat	8	7	2	2			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr2:167262324T>C	uc002udu.1	-	25	4942	c.4815A>G	c.(4813-4815)TTA>TTG	p.L1605L		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1605					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AAGGGTTGGCTAACAAAAACC	0.368													C	167262324	C	C	167262324	2	2	111	1	0	0	0	0	0	0	0	1	13923	1519	53	4		4	SCN7A	2	167262324	Silent	SNP	T	TCGA-12-0615-01A-01D-1492-08	68908100	167262324	75937049	12	7549											
DNAH7	56171	broad.mit.edu	37	chr2	196741332	196741332	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtccaattttgacatgacaAtattctgagtttgagctgct	8	7	1	4			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr2:196741332A>G	uc002utj.3	-	37	6154	c.6053T>C	c.(6052-6054)ATT>ACT	p.I2018T		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2018	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGACATGACAATATTCTGAGT	0.363													G	196741332	G	G	196741332	3	3	111	1	0	0	0	0	1	0	0	0	4606	101	4	4	6137	4	DNAH7	2	196741332	Missense_Mutation	SNP	A	TCGA-12-0615-01A-01D-1492-08	29479008	196741332	46458041	13	7550											
AAMP	14	broad.mit.edu	37	chr2	219131281	219131281	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcagctgtgcccgccaacagGacaggtgcccgaggatgcca	13	14	1	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr2:219131281G>A	uc002vhk.2	-	5	648	c.564C>T	c.(562-564)GTC>GTT	p.V188V	AAMP_uc002vhj.2_Silent_p.V169V|AAMP_uc010fvo.2_Silent_p.V188V|AAMP_uc002vhl.2_Silent_p.V189V	NM_001087	NP_001078	Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	188	WD 3.				angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCGCCAACAGGACAGGTGCCC	0.642													A	219131281	A	A	219131281	2	1	111	1	0	0	0	0	0	0	0	1	17	1161	41	3		3	AAMP	2	219131281	Silent	SNP	G	TCGA-12-0615-01A-01D-1492-08	22389949	219131281	24068092	14	7551											
SHISA5	51246	broad.mit.edu	37	chr3	48538580	48538580	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcacccacctggcctcagGcacagcacacctttcctcgc	8	19	1	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr3:48538580G>A	uc003ctp.1	-	2	357	c.223C>T	c.(223-225)CCT>TCT	p.P75S	SHISA5_uc003cto.1_Missense_Mutation_p.P44S|SHISA5_uc003ctq.1_Intron|SHISA5_uc003ctr.1_Missense_Mutation_p.P44S|SHISA5_uc003cts.1_Missense_Mutation_p.P44S	NM_016479	NP_057563	Q8N114	SHSA5_HUMAN	scotin precursor	75	Extracellular (Potential).				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	signal transducer activity|WW domain binding				0						CTGGCCTCAGGCACAGCACAC	0.572													A	48538580	A	A	48538580	3	1	111	1	0	0	0	0	1	0	0	0	14283	1203	42	3	519	3	SHISA5	3	48538580	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08		48538580	149483850	15	7552											
ERC2	26059	broad.mit.edu	37	chr3	56468977	56468977	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgaggagaccttggcaaaCgaggggatctggaagggcta	16	7	1	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr3:56468977C>T	uc003dhr.1	-	2	315	c.59G>A	c.(58-60)CGT>CAT	p.R20H		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	20						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CCTTGGCAAACGAGGGGATCT	0.468													T	56468977	T	T	56468977	3	4	111	1	0	0	0	0	1	0	0	0	5211	536	19	1	2868	1	ERC2	3	56468977	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	7930397	56468977	141553453	16	7553											
FAM19A1	407738	broad.mit.edu	37	chr3	68055847	68055847	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgctactctgccatggatcCcttcagcacactttccagca	6	15	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr3:68055847C>T	uc003dnd.2	+	2	294	c.78C>T	c.(76-78)TCC>TCT	p.S26S	FAM19A1_uc003dne.2_Silent_p.S26S|FAM19A1_uc003dng.2_Silent_p.S26S|FAM19A1_uc003dnf.1_RNA	NM_213609	NP_998774	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine	26						endoplasmic reticulum|extracellular region				ovary(1)	1		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		GCCATGGATCCCTTCAGCACA	0.502													T	68055847	T	T	68055847	2	4	111	1	0	0	0	0	0	0	0	1	5531	610	22	3		3	FAM19A1	3	68055847	Silent	SNP	C	TCGA-12-0615-01A-01D-1492-08	11586870	68055847	129966583	17	7554											
CNTN3	5067	broad.mit.edu	37	chr3	74316462	74316462	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttctccatggctttaacttgCtcccaattaagtaacacttt	4	11	1	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr3:74316462C>A	uc003dpm.1	-	20	2852	c.2772G>T	c.(2770-2772)GAG>GAT	p.E924D		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	924	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CTTTAACTTGCTCCCAATTAA	0.358													A	74316462	A	A	74316462	3	1	111	1	0	0	0	0	1	0	0	0	3642	796	28	5	326	5	CNTN3	3	74316462	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	6260615	74316462	123705968	18	7555											
LEPREL1	55214	broad.mit.edu	37	chr3	189700930	189700930	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgttcactcctgaagggaccCtgcccattcaaaaaatttaa	6	12	2	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr3:189700930C>T	uc011bsk.1	-	8	1618	c.1230_splice	c.e8-1	p.R410_splice	LEPREL1_uc003fsg.2_Splice_Site_p.R229_splice	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a						collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGAAGGGACCCTGCCCATTCA	0.393													T	189700930	T	T	189700930	5	4	111	1	0	0	0	0	0	0	1	0	8730	695	24	3	929	3	LEPREL1	3	189700930	Splice_Site	SNP	C	TCGA-12-0615-01A-01D-1492-08	115384468	189700930	8321500	19	7556											
WDR1	9948	broad.mit.edu	37	chr4	10086069	10086070	+	Frame_Shift_Ins	INS	-	T	T													tttgagtcaaaggatattaaINStgtgtccgtcgtggctccca							TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr4:10086069_10086070insT	uc003gmf.2	-	9	1319_1320	c.1036_1037insA	c.(1036-1038)ATTfs	p.I346fs	WDR1_uc003gmg.2_Frame_Shift_Ins_p.I206fs|WDR1_uc003gmh.1_RNA|WDR1_uc011bwu.1_Frame_Shift_Ins_p.I181fs|WDR1_uc010idm.2_5'Flank	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	346	WD 6.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		AAGGATATTAATGTGTCCGTCG	0.55													T	10086070	T	T	10086069	7	5	111	1	0	1	1	0	0	0	0	0	17269	101	4	0	811	0	WDR1	4	10086069	Frame_Shift_Ins	INS	-	TCGA-12-0615-01A-01D-1492-08		10086069	181068207	20	7557											
FRYL	285527	broad.mit.edu	37	chr4	48622786	48622786	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctctgctactgagctcatagAgcttatcaactgaaaacaca	6	11	3	3			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr4:48622786A>C	uc003gyh.1	-	6	789	c.184T>G	c.(184-186)TCT>GCT	p.S62A	FRYL_uc003gyk.2_Missense_Mutation_p.S62A|FRYL_uc003gyl.1_Missense_Mutation_p.S113A|FRYL_uc003gym.1_Missense_Mutation_p.S62A	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	62					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GAGCTCATAGAGCTTATCAAC	0.363													C	48622786	C	C	48622786	3	2	111	1	0	0	0	0	1	0	0	0	6064	304	11	5	9093	5	FRYL	4	48622786	Missense_Mutation	SNP	A	TCGA-12-0615-01A-01D-1492-08	38536717	48622786	142531490	21	7558											
SFRP2	6423	broad.mit.edu	37	chr4	154702675	154702675	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccttctgccaccgcttcacCgaggtgatcaccagctcccc	7	20	3	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr4:154702675C>T	uc003inv.1	-	3	1057	c.816G>A	c.(814-816)TCG>TCA	p.S272S		NM_003013	NP_003004	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2 precursor	272	NTR.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding	p.S272S(1)		ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.093)	Renal(120;0.117)				ACCGCTTCACCGAGGTGATCA	0.592													T	154702675	T	T	154702675	2	4	111	1	0	0	0	0	0	0	0	1	14162	639	23	2		2	SFRP2	4	154702675	Silent	SNP	C	TCGA-12-0615-01A-01D-1492-08	106079889	154702675	36451601	22	7559											
VCAN	1462	broad.mit.edu	37	chr5	82815367	82815367	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccacagtccaacctcaggcTatcacagatagtttagccac	7	14	2	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr5:82815367T>C	uc003kii.3	+	7	1598	c.1242T>C	c.(1240-1242)GCT>GCC	p.A414A	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Silent_p.A414A|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	414	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AACCTCAGGCTATCACAGATA	0.463													C	82815367	C	C	82815367	2	2	111	1	0	0	0	0	0	0	0	1	17135	1509	53	4		4	VCAN	5	82815367	Silent	SNP	T	TCGA-12-0615-01A-01D-1492-08		82815367	98099893	23	7560											
TRIM7	81786	broad.mit.edu	37	chr5	180622296	180622296	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtagaaggacacggctcccAcctccaggtccagggccacc	11	17	0	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr5:180622296A>G	uc003mmz.1	-	7	1473	c.1406T>C	c.(1405-1407)GTG>GCG	p.V469A	TRIM7_uc003mmv.1_Missense_Mutation_p.V287A|TRIM7_uc003mmw.1_Missense_Mutation_p.V261A|TRIM7_uc003mmx.1_Missense_Mutation_p.V261A|TRIM7_uc003mmy.1_Missense_Mutation_p.V261A	NM_203293	NP_976038	Q9C029	TRIM7_HUMAN	tripartite motif-containing 7 isoform 1	469	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		CACGGCTCCCACCTCCAGGTC	0.672													G	180622296	G	G	180622296	3	3	111	1	0	0	0	0	1	0	0	0	16540	159	6	4	133	4	TRIM7	5	180622296	Missense_Mutation	SNP	A	TCGA-12-0615-01A-01D-1492-08	97806929	180622296	292964	24	7561											
ANKS1A	23294	broad.mit.edu	37	chr6	34935028	34935028	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgatagcatgtggagaggGccaaatgtgaactgtgttga	14	6	0	4			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr6:34935028G>A	uc003ojx.3	+	2	352	c.210G>A	c.(208-210)GGG>GGA	p.G70G	ANKS1A_uc011dss.1_Silent_p.G70G|ANKS1A_uc011dst.1_5'UTR|ANKS1A_uc010jvp.1_5'UTR|ANKS1A_uc010jvq.1_5'Flank	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	70						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						TGTGGAGAGGGCCAAATGTGA	0.423													A	34935028	A	A	34935028	2	1	111	1	0	0	0	0	0	0	0	1	688	1190	42	3		3	ANKS1A	6	34935028	Silent	SNP	G	TCGA-12-0615-01A-01D-1492-08		34935028	136180039	25	7562											
GLP1R	2740	broad.mit.edu	37	chr6	39033981	39033981	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtgtgccacagagctccccGgaggagcagctcctgttcct	12	15	0	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr6:39033981G>A	uc003ooj.3	+	5	471	c.411G>A	c.(409-411)CCG>CCA	p.P137P	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	137	Extracellular (Potential).			P -> R (in Ref. 4; no nucleotide entry).|SP -> WG (in Ref. 1; AAA03614).	activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	AGAGCTCCCCGGAGGAGCAGC	0.597													A	39033981	A	A	39033981	2	1	111	1	0	0	0	0	0	0	0	1	6452	1103	39	2		2	GLP1R	6	39033981	Silent	SNP	G	TCGA-12-0615-01A-01D-1492-08	4098953	39033981	132081086	26	7563											
RNF217	154214	broad.mit.edu	37	chr6	125379096	125379096	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttcttacacagatccagtgCcctacctgccaattcgtctg	6	14	2	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr6:125379096C>T	uc003pzs.2	+	5	587	c.249C>T	c.(247-249)TGC>TGT	p.C83C	RNF217_uc003pzr.2_Silent_p.C140C|RNF217_uc003pzt.2_RNA	NM_152553	NP_689766	Q8TC41	RN217_HUMAN	ring finger protein 217	83	IBR-type.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		AGATCCAGTGCCCTACCTGCC	0.388													T	125379096	T	T	125379096	2	4	111	1	0	0	0	0	0	0	0	1	13481	747	26	3		3	RNF217	6	125379096	Silent	SNP	C	TCGA-12-0615-01A-01D-1492-08	86345115	125379096	45735971	27	7564											
HECA	51696	broad.mit.edu	37	chr6	139495543	139495543	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagactcatgcatctgtatgCcgtgtgcgtggactgcctgg	14	10	2	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr6:139495543C>T	uc003qin.2	+	3	1619	c.1334C>T	c.(1333-1335)GCC>GTC	p.A445V		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	445					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		CATCTGTATGCCGTGTGCGTG	0.502													T	139495543	T	T	139495543	3	4	111	1	0	0	0	0	1	0	0	0	7038	739	26	3	1344	3	HECA	6	139495543	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	14116447	139495543	31619524	28	7565											
SEPT14	346288	broad.mit.edu	37	chr7	55874801	55874801	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acctaactggctggttgtttGgacccacatctgtaaagccc	9	12	1	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr7:55874801G>C	uc003tqz.2	-	8	1085	c.968C>G	c.(967-969)CCA>CGA	p.P323R		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	323					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTGGTTGTTTGGACCCACATC	0.368													C	55874801	C	C	55874801	3	2	111	1	0	0	0	0	1	0	0	0	14063	1348	47	5	342	5	SEPT14	7	55874801	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08		55874801	103263862	29	7566											
TRIM4	89122	broad.mit.edu	37	chr7	99507253	99507253	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactttcttcatcttggccaCgagattacgctgagacttaa	8	10	3	2			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr7:99507253C>T	uc003usd.2	-	3	632	c.502G>A	c.(502-504)GTG>ATG	p.V168M	TRIM4_uc003use.2_Missense_Mutation_p.V142M|TRIM4_uc011kjc.1_Translation_Start_Site|TRIM4_uc003usf.2_Missense_Mutation_p.V142M	NM_033017	NP_148977	Q9C037	TRIM4_HUMAN	tripartite motif protein TRIM4 isoform alpha	168					protein trimerization	cytoplasm|plasma membrane	zinc ion binding			ovary(1)|kidney(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				ATCTTGGCCACGAGATTACGC	0.408													T	99507253	T	T	99507253	3	4	111	1	0	0	0	0	1	0	0	0	16511	536	19	1	1020	1	TRIM4	7	99507253	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	43632452	99507253	59631410	30	7567											
ATP6V0A4	50617	broad.mit.edu	37	chr7	138447096	138447096	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacactaaccccaactttccGgtcatatatgcaggcactgc	6	14	1	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr7:138447096G>A	uc003vuf.2	-	6	739	c.501C>T	c.(499-501)ACC>ACT	p.T167T	ATP6V0A4_uc003vug.2_Silent_p.T167T|ATP6V0A4_uc003vuh.2_Silent_p.T167T	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	167	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						CCAACTTTCCGGTCATATATG	0.458													A	138447096	A	A	138447096	2	1	111	1	0	0	0	0	0	0	0	1	1170	1103	39	2		2	ATP6V0A4	7	138447096	Silent	SNP	G	TCGA-12-0615-01A-01D-1492-08	38939843	138447096	20691567	31	7568											
SGK223	157285	broad.mit.edu	37	chr8	8239066	8239066	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttccaggcggcagttctcAggcctgggaggcaggcgcgg	17	12	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr8:8239066A>G	uc003wsh.3	-	1	192	c.192T>C	c.(190-192)CCT>CCC	p.P64P		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	64							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGCAGTTCTCAGGCCTGGGAG	0.652													G	8239066	G	G	8239066	2	3	111	1	0	0	0	0	0	0	0	1	14210	175	7	4		4	SGK223	8	8239066	Silent	SNP	A	TCGA-12-0615-01A-01D-1492-08		8239066	138124956	32	7569											
VCPIP1	80124	broad.mit.edu	37	chr8	67546807	67546807	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	atccatctcttcaagctcctCcacggaatttcccctttgtg	5	15	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr8:67546807C>A	uc003xwn.2	-	3	3857	c.3598G>T	c.(3598-3600)GAG>TAG	p.E1200*		NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	1200					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TCAAGCTCCTCCACGGAATTT	0.428													A	67546807	A	A	67546807	4	1	111	1	0	0	0	0	0	1	0	0	17138	864	30	5	74	5	VCPIP1	8	67546807	Nonsense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	59307741	67546807	78817215	33	7570											
SLC25A32	81034	broad.mit.edu	37	chr8	104412724	104412724	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tacagcaggctggagtcactCtaatcaaattaggagcaatt	9	8	3	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr8:104412724C>G	uc003yll.2	-	7	1166	c.863G>C	c.(862-864)AGA>ACA	p.R288T	SLC25A32_uc011lhr.1_Missense_Mutation_p.R156T	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	288	Solcar 3.|Helical; Name=6; (Potential).				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	TGGAGTCACTCTAATCAAATT	0.368													G	104412724	G	G	104412724	3	3	111	1	0	0	0	0	1	0	0	0	14496	913	32	5	88	5	SLC25A32	8	104412724	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	36865917	104412724	41951298	34	7571											
RECK	8434	broad.mit.edu	37	chr9	36060144	36060144	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttggaattgtatgaattcatCtttgccaggtaagcaataaa	8	5	2	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr9:36060144C>G	uc003zyv.2	+	4	349	c.263C>G	c.(262-264)TCT>TGT	p.S88C	RECK_uc010mld.2_Missense_Mutation_p.S88C|RECK_uc003zyu.3_Missense_Mutation_p.S88C|RECK_uc003zyw.2_Translation_Start_Site|RECK_uc010mle.1_Intron|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	88	5 X Knot repeats.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			ATGAATTCATCTTTGCCAGGT	0.299													G	36060144	G	G	36060144	3	3	111	1	0	0	0	0	1	0	0	0	13200	913	32	5	277	5	RECK	9	36060144	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08		36060144	105153287	35	7572											
TMEM2	23670	broad.mit.edu	37	chr9	74345061	74345061	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcggtgggcaggagagtacCcggcttggtgaggagtccca	17	9	0	2			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr9:74345061C>T	uc011lsa.1	-	9	2422	c.1882G>A	c.(1882-1884)GGT>AGT	p.G628S	TMEM2_uc010mos.2_Missense_Mutation_p.G565S|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	628						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AGGAGAGTACCCGGCTTGGTG	0.458													T	74345061	T	T	74345061	3	4	111	1	0	0	0	0	1	0	0	0	16118	623	22	3	2333	3	TMEM2	9	74345061	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	38284917	74345061	66868370	36	7573											
WNK2	65268	broad.mit.edu	37	chr9	96030055	96030055	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atgactttatcctgcaggccGagcgggaaacgttcatcgag	12	10	1	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr9:96030055G>A	uc004ati.1	+	16	3724	c.3724G>A	c.(3724-3726)GAG>AAG	p.E1242K	WNK2_uc011lud.1_Missense_Mutation_p.E1242K|WNK2_uc004atj.2_Missense_Mutation_p.E1242K|WNK2_uc004atk.2_Missense_Mutation_p.E879K	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1242					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CCTGCAGGCCGAGCGGGAAAC	0.577													A	96030055	A	A	96030055	3	1	111	1	0	0	0	0	1	0	0	0	17375	1059	37	2	3786	2	WNK2	9	96030055	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	21684994	96030055	45183376	37	7574											
NANS	54187	broad.mit.edu	37	chr9	100823174	100823174	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattcctgggggaagacgtaCggggagcacaaacgacatct	13	10	1	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr9:100823174C>T	uc004ayb.2	+	3	885	c.243C>T	c.(241-243)TAC>TAT	p.Y81Y	NANS_uc004ayc.2_Silent_p.Y81Y	NM_018946	NP_061819	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid phosphate synthase	81					lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GGAAGACGTACGGGGAGCACA	0.527													T	100823174	T	T	100823174	2	4	111	1	0	0	0	0	0	0	0	1	10155	547	19	1		1	NANS	9	100823174	Silent	SNP	C	TCGA-12-0615-01A-01D-1492-08	4793119	100823174	40390257	38	7575											
SVEP1	79987	broad.mit.edu	37	chr9	113173811	113173811	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cacttgccctgggcattgcaGagaagctgggaattgtctgc	13	10	1	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr9:113173811G>T	uc010mtz.2	-	37	6517	c.6180C>A	c.(6178-6180)CTC>CTA	p.L2060L	SVEP1_uc010mty.2_Translation_Start_Site	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2060	Sushi 11.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GGGCATTGCAGAGAAGCTGGG	0.512													T	113173811	T	T	113173811	2	4	111	1	0	0	0	0	0	0	0	1	15417	929	33	5		5	SVEP1	9	113173811	Silent	SNP	G	TCGA-12-0615-01A-01D-1492-08	12350637	113173811	28039620	39	7576											
FAM13C	220965	broad.mit.edu	37	chr10	61023889	61023889	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaaatcattcatccatttcAggacttcaggattagaagtc	6	10	4	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr10:61023889A>G	uc001jkn.2	-	10	1114	c.980T>C	c.(979-981)CTG>CCG	p.L327P	FAM13C_uc001jko.2_Intron|FAM13C_uc010qid.1_Missense_Mutation_p.L244P|FAM13C_uc010qie.1_Missense_Mutation_p.L244P|FAM13C_uc010qif.1_Missense_Mutation_p.L349P|FAM13C_uc001jkp.2_Missense_Mutation_p.L244P	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	327										ovary(2)	2						CATCCATTTCAGGACTTCAGG	0.289													G	61023889	G	G	61023889	3	3	111	1	0	0	0	0	1	0	0	0	5454	188	7	4	801	4	FAM13C	10	61023889	Missense_Mutation	SNP	A	TCGA-12-0615-01A-01D-1492-08		61023889	74510858	40	7577											
DCHS1	8642	broad.mit.edu	37	chr11	6655171	6655171	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcacttatactggcagcataCtcccgtggataaaactgagg	10	10	0	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr11:6655171C>G	uc001mem.1	-	4	2477	c.2067G>C	c.(2065-2067)GAG>GAC	p.E689D		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	689	Cadherin 7.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGCAGCATACTCCCGTGGAT	0.557													G	6655171	G	G	6655171	3	3	111	1	0	0	0	0	1	0	0	0	4287	564	20	5	7901	5	DCHS1	11	6655171	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08		6655171	128351345	41	7578											
WT1	7490	broad.mit.edu	37	chr11	32450114	32450114	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggaactgcgccgcatggtgcGagggcgtgtgaccgtagctg	18	10	0	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr11:32450114G>A	uc001mtn.1	-	2	894	c.698C>T	c.(697-699)TCG>TTG	p.S233L	WT1_uc001mtl.1_Missense_Mutation_p.S21L|WT1_uc001mtm.1_Missense_Mutation_p.S21L|WT1_uc001mto.1_Missense_Mutation_p.S233L|WT1_uc001mtp.1_Missense_Mutation_p.S233L|WT1_uc001mtq.1_Missense_Mutation_p.S233L|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	165					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			CGCATGGTGCGAGGGCGTGTG	0.632			D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				A	32450114	A	A	32450114	3	1	111	1	0	0	0	0	1	0	0	0	17405	1059	37	2	891	2	WT1	11	32450114	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	25794943	32450114	102556402	42	7579											
SLC22A25	387601	broad.mit.edu	37	chr11	62948177	62948177	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttacatatgttgggtatgCggagcaattcacaaagagaa	10	5	1	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr11:62948177C>T	uc001nwr.1	-	6	1025	c.1025G>A	c.(1024-1026)CGC>CAC	p.R342H	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA|SLC22A25_uc001nwt.1_Missense_Mutation_p.R342H	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	342	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						GTTGGGTATGCGGAGCAATTC	0.383													T	62948177	T	T	62948177	3	4	111	1	0	0	0	0	1	0	0	0	14454	768	27	1	634	1	SLC22A25	11	62948177	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	30498063	62948177	72058339	43	7580											
ARAP1	116985	broad.mit.edu	37	chr11	72423533	72423533	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcctcatccccttggtcGtccccagacagttcctctcc	5	19	3	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr11:72423533G>A	uc001osu.2	-	6	1017	c.828C>T	c.(826-828)GAC>GAT	p.D276D	ARAP1_uc001osv.2_Silent_p.D276D|ARAP1_uc001osr.2_Silent_p.D36D|ARAP1_uc001oss.2_Silent_p.D31D|ARAP1_uc009yth.2_Silent_p.D31D|ARAP1_uc010rre.1_Silent_p.D31D	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	276					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						CCCCTTGGTCGTCCCCAGACA	0.682													A	72423533	A	A	72423533	2	1	111	1	0	0	0	0	0	0	0	1	838	1136	40	1		1	ARAP1	11	72423533	Silent	SNP	G	TCGA-12-0615-01A-01D-1492-08	9475356	72423533	62582983	44	7581											
PRCP	5547	broad.mit.edu	37	chr11	82564244	82564244	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgagttgtcaccaaaggggAgagactctccatagtatcga	11	8	2	2			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr11:82564244A>G	uc001ozs.2	-	3	499	c.386T>C	c.(385-387)CTC>CCC	p.L129P	PRCP_uc001ozr.2_Missense_Mutation_p.L150P	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	129					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						ACCAAAGGGGAGAGACTCTCC	0.363													G	82564244	G	G	82564244	3	3	111	1	0	0	0	0	1	0	0	0	12449	304	11	4	1132	4	PRCP	11	82564244	Missense_Mutation	SNP	A	TCGA-12-0615-01A-01D-1492-08	10140711	82564244	52442272	45	7582											
TMEM19	55266	broad.mit.edu	37	chr12	72092727	72092727	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccttgtctccagtctccttGgtggtacctttgtgggcatt	11	11	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr12:72092727G>A	uc001sws.2	+	5	1268	c.685G>A	c.(685-687)GGT>AGT	p.G229S	TMEM19_uc001swr.1_Missense_Mutation_p.G215S|TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	229	Helical; (Potential).					integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CAGTCTCCTTGGTGGTACCTT	0.443													A	72092727	A	A	72092727	3	1	111	1	0	0	0	0	1	0	0	0	16110	1348	47	3	703	3	TMEM19	12	72092727	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08		72092727	61759168	46	7583											
SOCS2	8835	broad.mit.edu	37	chr12	93968661	93968661	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcgaatcgaataccaagaCggaaaattcagattggactc	8	9	1	2	rs148086876		TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr12:93968661C>T	uc001tcw.1	+	3	893	c.303C>T	c.(301-303)GAC>GAT	p.D101D	SOCS2_uc001tcx.1_Silent_p.D101D|SOCS2_uc009zsu.2_3'UTR|SOCS2_uc001tcy.1_Silent_p.D101D|SOCS2_uc001tcz.2_3'UTR	NM_003877	NP_003868	O14508	SOCS2_HUMAN	suppressor of cytokine signaling-2	101	SH2.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity			lung(1)	1						AATACCAAGACGGAAAATTCA	0.378													T	93968661	T	T	93968661	2	4	111	1	0	0	0	0	0	0	0	1	14914	535	19	1		1	SOCS2	12	93968661	Silent	SNP	C	TCGA-12-0615-01A-01D-1492-08	21875934	93968661	39883234	47	7584											
RIC8B	55188	broad.mit.edu	37	chr12	107208579	107208579	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctccagagacaaaaaggttTtagttcctgtgacaactaag	8	8	1	2			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr12:107208579T>G	uc001tlx.2	+	3	363	c.238T>G	c.(238-240)TTA>GTA	p.L80V	RIC8B_uc001tlw.2_Missense_Mutation_p.L80V|RIC8B_uc001tly.2_Missense_Mutation_p.L40V|RIC8B_uc001tlz.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	80					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						CAAAAAGGTTTTAGTTCCTGT	0.413													G	107208579	G	G	107208579	3	3	111	1	0	0	0	0	1	0	0	0	13356	1838	64	5	248	5	RIC8B	12	107208579	Missense_Mutation	SNP	T	TCGA-12-0615-01A-01D-1492-08	13239918	107208579	26643316	48	7585											
MLXIP	22877	broad.mit.edu	37	chr12	122613736	122613736	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcatcgagattgtgatccGggagtatcacaagtggagaa	13	8	1	3			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr12:122613736G>A	uc001ubq.2	+	4	659	c.659G>A	c.(658-660)CGG>CAG	p.R220Q	MLXIP_uc001ubr.2_5'UTR|MLXIP_uc001ubs.1_5'Flank	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein	220	Required for cytoplasmic localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		ATTGTGATCCGGGAGTATCAC	0.557													A	122613736	A	A	122613736	3	1	111	1	0	0	0	0	1	0	0	0	9636	1116	39	2	673	2	MLXIP	12	122613736	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	15405157	122613736	11238159	49	7586											
NUBP1	4682	broad.mit.edu	37	chr16	10837884	10837884	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagggatgccccaaccagcGgctgtgcgcttctggagcgg	15	13	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr16:10837884G>A	uc002daa.1	+	2	109	c.86G>A	c.(85-87)CGG>CAG	p.R29Q	NUBP1_uc010bum.1_5'UTR|NUBP1_uc002dab.1_Missense_Mutation_p.R29Q	NM_002484	NP_002475	P53384	NUBP1_HUMAN	nucleotide binding protein 1	29					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			ovary(1)|skin(1)	2						CCCAACCAGCGGCTGTGCGCT	0.657													A	10837884	A	A	10837884	3	1	111	1	0	0	0	0	1	0	0	0	10715	1116	39	2	92	2	NUBP1	16	10837884	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08		10837884	79516869	50	7587											
C17orf74	201243	broad.mit.edu	37	chr17	7330635	7330635	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcggaccctgcccctccccCgaccatgtttgtcccactca	7	20	1	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr17:7330635C>T	uc002ggw.2	+	3	1398	c.1325C>T	c.(1324-1326)CCG>CTG	p.P442L	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	442						integral to membrane					0		Prostate(122;0.157)				GCCCCTCCCCCGACCATGTTT	0.647													T	7330635	T	T	7330635	3	4	111	1	0	0	0	0	1	0	0	0	1879	652	23	2	1335	2	C17orf74	17	7330635	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08		7330635	73864575	51	7588											
PIK3R5	23533	broad.mit.edu	37	chr17	8792082	8792082	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagcagggaatctctctcgGcacagtgcccgtcagtttcc	11	13	3	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr17:8792082G>A	uc002glt.2	-	10	1089	c.1022C>T	c.(1021-1023)GCC>GTC	p.A341V	PIK3R5_uc010vuz.1_Missense_Mutation_p.A341V|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Missense_Mutation_p.P290S|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	341				DILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGH CAERDSLLSTSSLASHDSTLSLASSQASG -> GNIEGDPG PRRPDSAGLASLQTSCRKSCSRNRSYSSQGSWEMMKRRERR RRRWRRTWKLTGTVPREIPCS (in Ref. 6; AAW63121).	platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						ATCTCTCTCGGCACAGTGCCC	0.502													A	8792082	A	A	8792082	3	1	111	1	0	0	0	0	1	0	0	0	11922	1203	42	3	1660	3	PIK3R5	17	8792082	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	1461447	8792082	72403128	52	7589											
FBXW10	10517	broad.mit.edu	37	chr17	18651317	18651317	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaccacagctccaagtctgCgacctcacaagtctattgga	8	13	3	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr17:18651317C>T	uc002guk.2	+	2	801	c.569C>T	c.(568-570)GCG>GTG	p.A190V	FBXW10_uc002guj.2_Missense_Mutation_p.A190V|FBXW10_uc002gul.2_Missense_Mutation_p.A190V|FBXW10_uc010cqh.1_Missense_Mutation_p.A190V	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	190	WD 1.									ovary(1)	1						TCCAAGTCTGCGACCTCACAA	0.478													T	18651317	T	T	18651317	3	4	111	1	0	0	0	0	1	0	0	0	5763	768	27	1	575	1	FBXW10	17	18651317	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	9859235	18651317	62543893	53	7590											
PIPOX	51268	broad.mit.edu	37	chr17	27380567	27380567	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggtcatcacagcaggtccttGgaccaaccagctcctccgtc	9	16	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr17:27380567G>C	uc002hdr.1	+	4	940	c.614G>C	c.(613-615)TGG>TCG	p.W205S		NM_016518	NP_057602	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	205					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity				0	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	GCAGGTCCTTGGACCAACCAG	0.517													C	27380567	C	C	27380567	3	2	111	1	0	0	0	0	1	0	0	0	11943	1357	47	5	628	5	PIPOX	17	27380567	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	8729250	27380567	53814643	54	7591											
SLC35B1	10237	broad.mit.edu	37	chr17	47780551	47780551	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcccctttcaagcactcaccTgacccagggcactggtcagc	8	17	3	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr17:47780551T>C	uc002iph.1	-	7	848	c.761A>G	c.(760-762)CAG>CGG	p.Q254R	SLC35B1_uc002ipi.1_Missense_Mutation_p.Q187R|SLC35B1_uc002ipj.1_Missense_Mutation_p.Q130R	NM_005827	NP_005818	P78383	S35B1_HUMAN	solute carrier family 35, member B1	254	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0						AGCACTCACCTGACCCAGGGC	0.547													C	47780551	C	C	47780551	3	2	111	1	0	0	0	0	1	0	0	0	14575	1594	55	4	219	4	SLC35B1	17	47780551	Missense_Mutation	SNP	T	TCGA-12-0615-01A-01D-1492-08	20399984	47780551	33414659	55	7592											
KCNH6	81033	broad.mit.edu	37	chr17	61613122	61613122	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgctactctgagtatggggcGgctgtgctcttcttgctcat	12	11	4	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr17:61613122G>A	uc002jay.2	+	6	1274	c.1194G>A	c.(1192-1194)GCG>GCA	p.A398A	KCNH6_uc002jax.1_Silent_p.A398A|KCNH6_uc010wpl.1_Silent_p.A275A|KCNH6_uc010wpm.1_Silent_p.A398A|KCNH6_uc002jaz.1_Silent_p.A398A	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	398	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	AGTATGGGGCGGCTGTGCTCT	0.617													A	61613122	A	A	61613122	2	1	111	1	0	0	0	0	0	0	0	1	8036	1103	39	2		2	KCNH6	17	61613122	Silent	SNP	G	TCGA-12-0615-01A-01D-1492-08	13832571	61613122	19582088	56	7593											
TMEM105	284186	broad.mit.edu	37	chr17	79287573	79287573	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaagaaagccagactgccCccaggcaggcccttcatgtc	10	15	1	2			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr17:79287573C>T	uc002kad.1	-	3	818	c.268G>A	c.(268-270)GGG>AGG	p.G90R		NM_178520	NP_848615	Q8N8V8	TM105_HUMAN	transmembrane protein 105	90						integral to membrane				ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			CCAGACTGCCCCCAGGCAGGC	0.662													T	79287573	T	T	79287573	3	4	111	1	0	0	0	0	1	0	0	0	16016	623	22	3	125	3	TMEM105	17	79287573	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	17674451	79287573	1907637	57	7594											
LAMA1	284217	broad.mit.edu	37	chr18	7010303	7010303	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	accacctttgatgagaacttGaggctcaaaattggaggtgc	11	8	1	3			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr18:7010303G>C	uc002knm.2	-	26	3863	c.3769C>G	c.(3769-3771)CAA>GAA	p.Q1257E	LAMA1_uc010wzj.1_Missense_Mutation_p.Q733E	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1257	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATGAGAACTTGAGGCTCAAAA	0.463													C	7010303	C	C	7010303	3	2	111	1	0	0	0	0	1	0	0	0	8605	1299	45	5	5610	5	LAMA1	18	7010303	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08		7010303	71066945	58	7595											
MIDN	90007	broad.mit.edu	37	chr19	1250466	1250466	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gagacggtggaggggctgcgCaagcggttgtcccagcgcct	18	11	0	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr19:1250466C>G	uc002lrp.2	+	2	686	c.171C>G	c.(169-171)CGC>CGG	p.R57R		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	57	Ubiquitin-like.					nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGGCTGCGCAAGCGGTTGT	0.493													G	1250466	G	G	1250466	2	3	111	1	0	0	0	0	0	0	0	1	9579	697	25	5		5	MIDN	19	1250466	Silent	SNP	C	TCGA-12-0615-01A-01D-1492-08		1250466	57878517	59	7596											
RAVER1	125950	broad.mit.edu	37	chr19	10444148	10444148	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccccagacttagggctcagCgggggccggtgagtaacgga	17	11	1	2			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr19:10444148C>T	uc002moa.2	-	1	167	c.87G>A	c.(85-87)CCG>CCA	p.P29P		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	12						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			TAGGGCTCAGCGGGGGCCGGT	0.692													T	10444148	T	T	10444148	2	4	111	1	0	0	0	0	0	0	0	1	13094	755	27	1		1	RAVER1	19	10444148	Silent	SNP	C	TCGA-12-0615-01A-01D-1492-08	9193682	10444148	48684835	60	7597											
USHBP1	83878	broad.mit.edu	37	chr19	17366376	17366376	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taggccccgcttctcacgccGcaccagctgcagccgaagca	10	18	1	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr19:17366376G>A	uc002nfs.1	-	10	1623	c.1510C>T	c.(1510-1512)CGG>TGG	p.R504W	USHBP1_uc002nfr.1_Missense_Mutation_p.R130W|USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Missense_Mutation_p.R440W	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	504	Potential.						PDZ domain binding			ovary(1)	1						TTCTCACGCCGCACCAGCTGC	0.647													A	17366376	A	A	17366376	3	1	111	1	0	0	0	0	1	0	0	0	17034	1086	38	1	617	1	USHBP1	19	17366376	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	6922228	17366376	41762607	61	7598											
DUXA	503835	broad.mit.edu	37	chr19	57669765	57669766	+	Frame_Shift_Ins	INS	-	T	T													aatcaatcccaggatatgggINStttttcataaatgccttgat							TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr19:57669765_57669766insT	uc002qoa.1	-	4	413_414	c.368_369insA	c.(367-369)AACfs	p.N123fs		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	123	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		CAGGATATGGGTTTTTCATAAA	0.47													T	57669766	T	T	57669765	7	5	111	1	0	1	1	0	0	0	0	0	4834	1252	44	0	257	0	DUXA	19	57669765	Frame_Shift_Ins	INS	-	TCGA-12-0615-01A-01D-1492-08	40303389	57669765	1459218	62	7599											
PROKR2	128674	broad.mit.edu	37	chr20	5282952	5282952	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggggaagaagtcacgaaCgatggtgaaaccgtagaagg	16	5	1	3	rs139399061	byFrequency	TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr20:5282952C>T	uc010zqw.1	-	2	889	c.889G>A	c.(889-891)GTT>ATT	p.V297I	PROKR2_uc010zqx.1_Missense_Mutation_p.V297I|PROKR2_uc010zqy.1_Missense_Mutation_p.V297I	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	297	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						AAGTCACGAACGATGGTGAAA	0.562										HNSCC(71;0.22)			T	5282952	T	T	5282952	3	4	111	1	0	0	0	0	1	0	0	0	12553	536	19	1	268	1	PROKR2	20	5282952	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08		5282952	57742568	63	7600											
PCSK2	5126	broad.mit.edu	37	chr20	17389925	17389925	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaatgccgaagcaagttaCgacttcagcagcaacgaccc	9	13	1	1	rs139215444	byFrequency	TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr20:17389925C>T	uc002wpm.2	+	6	881	c.561C>T	c.(559-561)TAC>TAT	p.Y187Y	PCSK2_uc002wpl.2_Silent_p.Y168Y|PCSK2_uc010zrm.1_Silent_p.Y152Y	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	187	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAGCAAGTTACGACTTCAGCA	0.483													T	17389925	T	T	17389925	2	4	111	1	0	0	0	0	0	0	0	1	11601	547	19	1		1	PCSK2	20	17389925	Silent	SNP	C	TCGA-12-0615-01A-01D-1492-08	12106973	17389925	45635595	64	7601											
OPRL1	4987	broad.mit.edu	37	chr20	62729348	62729348	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagcaccttcaccctaactGccatgagtgtggatcgctat	8	14	1	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr20:62729348G>A	uc002yic.2	+	4	829	c.427G>A	c.(427-429)GCC>ACC	p.A143T	OPRL1_uc002yid.2_Missense_Mutation_p.A143T|OPRL1_uc002yif.3_Missense_Mutation_p.A138T	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	143	Helical; Name=3; (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					CACCCTAACTGCCATGAGTGT	0.572													A	62729348	A	A	62729348	3	1	111	1	0	0	0	0	1	0	0	0	10886	1319	46	3	433	3	OPRL1	20	62729348	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	45339423	62729348	296172	65	7602											
TMPRSS15	5651	broad.mit.edu	37	chr21	19775931	19775931	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctagaagatatgcctcttttCgaccccatttttggttttga	7	9	1	3			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr21:19775931C>T	uc002ykw.2	-	1	40	c.9G>A	c.(7-9)TCG>TCA	p.S3S		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	3	Cytoplasmic (Potential).				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TGCCTCTTTTCGACCCCATTT	0.353													T	19775931	T	T	19775931	2	4	111	1	0	0	0	0	0	0	0	1	16243	871	31	2		2	TMPRSS15	21	19775931	Silent	SNP	C	TCGA-12-0615-01A-01D-1492-08		19775931	28353964	66	7603											
CLDN17	26285	broad.mit.edu	37	chr21	31538845	31538845	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccaacaaaagctgatactcTccactgaggcagaagggttg	11	10	1	3			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr21:31538845T>C	uc011acv.1	-	1	91	c.91A>G	c.(91-93)AGA>GGA	p.R31G		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	31	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						GCTGATACTCTCCACTGAGGC	0.507													C	31538845	C	C	31538845	3	2	111	1	0	0	0	0	1	0	0	0	3478	1559	54	4	587	4	CLDN17	21	31538845	Missense_Mutation	SNP	T	TCGA-12-0615-01A-01D-1492-08	11762914	31538845	16591050	67	7604											
MX2	4600	broad.mit.edu	37	chr21	42762561	42762561	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tggtggtggttccctgtaacGtggacattgccaccacggag	14	10	0	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr21:42762561G>C	uc002yzf.1	+	6	906	c.802G>C	c.(802-804)GTG>CTG	p.V268L	MX2_uc011aer.1_Intron|MX2_uc002yzg.1_5'UTR	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	268					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				TCCCTGTAACGTGGACATTGC	0.507													C	42762561	C	C	42762561	3	2	111	1	0	0	0	0	1	0	0	0	9998	1145	40	5	820	5	MX2	21	42762561	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08	11223716	42762561	5367334	68	7605											
CELSR1	9620	broad.mit.edu	37	chr22	46930786	46930786	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccgtcggatgctgtcaccGccagcacgtactgctgctcc	11	16	1	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chr22:46930786G>A	uc003bhw.1	-	1	2282	c.2282C>T	c.(2281-2283)GCG>GTG	p.A761V		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	761	Extracellular (Potential).|Cadherin 5.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGCTGTCACCGCCAGCACGTA	0.602													A	46930786	A	A	46930786	3	1	111	1	0	0	0	0	1	0	0	0	3221	1087	38	1	6902	1	CELSR1	22	46930786	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08		46930786	4373780	69	7606											
MXRA5	25878	broad.mit.edu	37	chrX	3228536	3228536	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccacaccaggctgggtgtcgGggtccccgcggcagagcagt	16	14	0	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chrX:3228536G>T	uc004crg.3	-	7	7865	c.7708C>A	c.(7708-7710)CCG>ACG	p.P2570T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2570	Ig-like C2-type 10.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTGGGTGTCGGGGTCCCCGCG	0.622													T	3228536	T	T	3228536	3	4	111	1	0	0	0	0	1	0	0	0	10003	1232	43	5	782	5	MXRA5	23	3228536	Missense_Mutation	SNP	G	TCGA-12-0615-01A-01D-1492-08		3228536	152042024	70	7607											
WWC3	55841	broad.mit.edu	37	chrX	10066544	10066544	+	Splice_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttctctcttctgttccggaaAgtttgtctttgatgataaaa	7	7	4	2			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chrX:10066544A>T	uc004csx.3	+	8	856	c.658_splice	c.e8-2	p.F220_splice	WWC3_uc010nds.2_Splice_Site|WWC3_uc010ndt.2_Splice_Site	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3											ovary(4)	4						TGTTCCGGAAAGTTTGTCTTT	0.348													T	10066544	T	T	10066544	5	4	111	1	0	0	0	0	0	0	1	0	17410	86	3	5	682	5	WWC3	23	10066544	Splice_Site	SNP	A	TCGA-12-0615-01A-01D-1492-08	6838008	10066544	145204016	71	7608											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29973596	29973596	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agcaagggccttttggggagCtgcagactgtctcggccatt	14	10	1	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chrX:29973596C>G	uc004dby.2	+	11	2258	c.1750C>G	c.(1750-1752)CTG>GTG	p.L584V		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	584	Cytoplasmic (Potential).|Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TTTTGGGGAGCTGCAGACTGT	0.507													G	29973596	G	G	29973596	3	3	111	1	0	0	0	0	1	0	0	0	7661	796	28	5	1788	5	IL1RAPL1	23	29973596	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	19907052	29973596	125296964	72	7609											
CXorf59	286464	broad.mit.edu	37	chrX	36103484	36103484	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcgccaccccaaaagttttCcagacagaatgacttttcca	5	14	0	3			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chrX:36103484C>T	uc004ddk.1	+	5	656	c.470C>T	c.(469-471)TCC>TTC	p.S157F		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	157						integral to membrane				central_nervous_system(1)	1						CAAAAGTTTTCCAGACAGAAT	0.328													T	36103484	T	T	36103484	3	4	111	1	0	0	0	0	1	0	0	0	4115	855	30	3	484	3	CXorf59	23	36103484	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	6129888	36103484	119167076	73	7610											
TEX13A	56157	broad.mit.edu	37	chrX	104463874	104463874	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatcaaaggcctcccagtcGgaaggcagctgaggcggaac	14	11	1	1			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chrX:104463874G>A	uc004ema.2	-	5	1114	c.1002C>T	c.(1000-1002)TCC>TCT	p.S334S	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Missense_Mutation_p.P335L	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	334						intracellular	zinc ion binding			ovary(2)	2						CCTCCCAGTCGGAAGGCAGCT	0.537													A	104463874	A	A	104463874	2	1	111	1	0	0	0	0	0	0	0	1	15773	1116	39	2		2	TEX13A	23	104463874	Silent	SNP	G	TCGA-12-0615-01A-01D-1492-08	68360390	104463874	50806686	74	7611											
ODZ1	10178	broad.mit.edu	37	chrX	123514489	123514489	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaacaaaatacccatcgtaaCcttgtacccgcccagtgctc	5	15	0	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chrX:123514489C>A	uc004euj.2	-	31	8139	c.8075G>T	c.(8074-8076)GGT>GTT	p.G2692V	ODZ1_uc011muj.1_Missense_Mutation_p.G2698V|ODZ1_uc010nqy.2_Missense_Mutation_p.G2699V	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2692	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CCCATCGTAACCTTGTACCCG	0.463													A	123514489	A	A	123514489	3	1	111	1	0	0	0	0	1	0	0	0	10834	507	18	5	106	5	ODZ1	23	123514489	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	19050615	123514489	31756071	75	7612											
PDZD4	57595	broad.mit.edu	37	chrX	153069052	153069052	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcgccgcttccgctgctcaCgggcccggatcaggtgctgc	14	17	2	0			TCGA-12-0615-01A-01D-1492-08	TCGA-12-0615-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6068793-51e4-4762-9150-cdfb030e8ade	c90ff476-f8e2-41b0-977d-fb36577427f4	g.chrX:153069052C>T	uc004fiz.1	-	8	2316	c.2066G>A	c.(2065-2067)CGT>CAT	p.R689H	PDZD4_uc004fiy.1_Missense_Mutation_p.R614H|PDZD4_uc004fix.2_Missense_Mutation_p.R593H|PDZD4_uc004fja.1_Missense_Mutation_p.R695H|PDZD4_uc011mze.1_Missense_Mutation_p.R580H	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	689						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGCTGCTCACGGGCCCGGAT	0.647													T	153069052	T	T	153069052	3	4	111	1	0	0	0	0	1	0	0	0	11703	536	19	1	247	1	PDZD4	23	153069052	Missense_Mutation	SNP	C	TCGA-12-0615-01A-01D-1492-08	29554563	153069052	2201508	76	7613											
HSPG2	3339	broad.mit.edu	37	chr1	22186712	22186712	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgcacactggggttacccaCgtaacctgggccacacctgt	10	14	0	0	rs143523507		TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr1:22186712C>T	uc001bfj.2	-	40	5012	c.4972G>A	c.(4972-4974)GTG>ATG	p.V1658M	HSPG2_uc009vqd.2_Missense_Mutation_p.V1659M	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1658	Laminin EGF-like 11.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGGTTACCCACGTAACCTGGG	0.637													T	22186712	T	T	22186712	3	4	112	1	0	0	0	0	1	0	0	0	7430	536	19	1	8435	1	HSPG2	1	22186712	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08		22186712	227063909	1	7614											
C1orf130	400746	broad.mit.edu	37	chr1	24927454	24927454	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggagccattgttgctgccGttgtggtggttgtcatcatc	13	9	2	0	rs142867139	byFrequency	TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr1:24927454G>A	uc001bjk.1	+	3	172	c.106G>A	c.(106-108)GTT>ATT	p.V36I		NM_001010980	NP_001010980	Q5T1S8	CA130_HUMAN	chromosome 1 open reading frame 130	36	Poly-Val.|Helical; (Potential).					integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.0119)|all_lung(284;0.0154)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0439)|OV - Ovarian serous cystadenocarcinoma(117;1.48e-24)|Colorectal(126;6.93e-08)|COAD - Colon adenocarcinoma(152;3.69e-06)|GBM - Glioblastoma multiforme(114;0.00036)|BRCA - Breast invasive adenocarcinoma(304;0.00189)|KIRC - Kidney renal clear cell carcinoma(1967;0.00382)|STAD - Stomach adenocarcinoma(196;0.00521)|READ - Rectum adenocarcinoma(331;0.0659)|Lung(427;0.144)		TGTTGCTGCCGTTGTGGTGGT	0.552													A	24927454	A	A	24927454	3	1	112	1	0	0	0	0	1	0	0	0	1997	1145	40	1	112	1	C1orf130	1	24927454	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	2740742	24927454	224323167	2	7615											
TTC39A	22996	broad.mit.edu	37	chr1	51768762	51768762	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgtacacctaccgagcaCgaaggtgaggaaggtgtggt	14	10	0	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr1:51768762C>T	uc001csl.2	-	9	970	c.865G>A	c.(865-867)GTG>ATG	p.V289M	TTC39A_uc001csk.2_Missense_Mutation_p.V254M|TTC39A_uc010ond.1_Missense_Mutation_p.V226M|TTC39A_uc010one.1_Missense_Mutation_p.V253M|TTC39A_uc010onf.1_Missense_Mutation_p.V257M|TTC39A_uc001csn.2_Missense_Mutation_p.V288M|TTC39A_uc001cso.1_Missense_Mutation_p.V285M|TTC39A_uc009vyy.1_Missense_Mutation_p.V226M	NM_001080494	NP_001073963	Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A isoform 2	289							binding			skin(1)	1						CTACCGAGCACGAAGGTGAGG	0.627													T	51768762	T	T	51768762	3	4	112	1	0	0	0	0	1	0	0	0	16704	536	19	1	1016	1	TTC39A	1	51768762	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08	26841308	51768762	197481859	3	7616											
DMRTB1	63948	broad.mit.edu	37	chr1	53932300	53932300	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cagaggtactgtcgggtgagCccagccagccatcgtctcag	13	13	1	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr1:53932300C>G	uc001cvq.1	+	4	1049	c.994C>G	c.(994-996)CCC>GCC	p.P332A		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	332					sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GTCGGGTGAGCCCAGCCAGCC	0.552													G	53932300	G	G	53932300	3	3	112	1	0	0	0	0	1	0	0	0	4590	739	26	5	1008	5	DMRTB1	1	53932300	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08	2163538	53932300	195318321	4	7617											
SFRS11	9295	broad.mit.edu	37	chr1	70703140	70703140	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agctgctggtctcgtttcacCaagtctgaaatcggatacct	9	11	3	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr1:70703140C>G	uc001des.2	+	7	747	c.623C>G	c.(622-624)CCA>CGA	p.P208R	SFRS11_uc001det.2_Missense_Mutation_p.P208R|SFRS11_uc001deu.2_Missense_Mutation_p.P208R|SFRS11_uc001dev.2_Missense_Mutation_p.P18R|SFRS11_uc001dew.2_Missense_Mutation_p.P148R	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	208					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						CTCGTTTCACCAAGTCTGAAA	0.378													G	70703140	G	G	70703140	3	3	112	1	0	0	0	0	1	0	0	0	14166	594	21	5	645	5	SFRS11	1	70703140	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08	16770840	70703140	178547481	5	7618											
S100A7A	338324	broad.mit.edu	37	chr1	153391728	153391728	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttgctgggagacatagcCgcagactaccacaagcagag	11	12	0	3			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr1:153391728C>T	uc001fbt.1	+	3	306	c.249C>T	c.(247-249)GCC>GCT	p.A83A		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	83	EF-hand 2.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGACATAGCCGCAGACTACC	0.522													T	153391728	T	T	153391728	2	4	112	1	0	0	0	0	0	0	0	1	13784	639	23	2		2	S100A7A	1	153391728	Silent	SNP	C	TCGA-12-0616-01A-01D-1492-08	82688588	153391728	95858893	6	7619											
FDPS	2224	broad.mit.edu	37	chr1	155287783	155287783	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatggattcatcccttaccCgccggggacagatctgctgg	11	13	3	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr1:155287783C>T	uc001fkc.2	+	5	751	c.532C>T	c.(532-534)CGC>TGC	p.R178C	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Missense_Mutation_p.R112C|FDPS_uc001fke.2_Missense_Mutation_p.R178C|FDPS_uc001fkf.2_Missense_Mutation_p.R112C|C1orf104_uc001fkh.1_RNA|RUSC1_uc001fkj.2_5'Flank|RUSC1_uc001fkk.2_5'Flank	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	178		Dimethylallyl diphosphate.			cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	ATCCCTTACCCGCCGGGGACA	0.512													T	155287783	T	T	155287783	3	4	112	1	0	0	0	0	1	0	0	0	5803	652	23	2	546	2	FDPS	1	155287783	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08	1896055	155287783	93962838	7	7620											
ADCY10	55811	broad.mit.edu	37	chr1	167806486	167806486	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacaatgatatatgcctctaCctgcgattttcaggaaaaaa	6	8	2	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr1:167806486C>T	uc001ger.2	-	22	3375	c.3077_splice	c.e22+1	p.S1026_splice	ADCY10_uc009wvk.2_Splice_Site_p.S934_splice|ADCY10_uc010plj.1_Splice_Site_p.S873_splice	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10						intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding	p.?(1)		central_nervous_system(2)|ovary(1)	3						TATGCCTCTACCTGCGATTTT	0.348													T	167806486	T	T	167806486	5	4	112	1	0	0	0	0	0	0	1	0	293	521	18	3	1802	3	ADCY10	1	167806486	Splice_Site	SNP	C	TCGA-12-0616-01A-01D-1492-08	12518703	167806486	81444135	8	7621											
TMEM63A	9725	broad.mit.edu	37	chr1	226040425	226040425	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgacagtgaagacacacaGcatccatgcatacatggctc	9	11	0	3			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr1:226040425G>A	uc001hpm.1	-	20	2093	c.1843C>T	c.(1843-1845)CTG>TTG	p.L615L		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	615	Helical; (Potential).					integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					AAGACACACAGCATCCATGCA	0.552													A	226040425	A	A	226040425	2	1	112	1	0	0	0	0	0	0	0	1	16187	962	34	3		3	TMEM63A	1	226040425	Silent	SNP	G	TCGA-12-0616-01A-01D-1492-08	58233939	226040425	23210196	9	7622											
VIT	5212	broad.mit.edu	37	chr2	37035618	37035618	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccctctgtcttctaggccGtgtgcagaacaaacggcttc	9	14	3	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr2:37035618G>A	uc002rpl.2	+	15	1614	c.1393G>A	c.(1393-1395)GTG>ATG	p.V465M	VIT_uc002rpm.2_Missense_Mutation_p.V443M|VIT_uc010ezv.2_Missense_Mutation_p.V421M|VIT_uc010ezw.2_Missense_Mutation_p.V422M	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	450	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				CTTCTAGGCCGTGTGCAGAAC	0.602													A	37035618	A	A	37035618	3	1	112	1	0	0	0	0	1	0	0	0	17168	1145	40	1	1572	1	VIT	2	37035618	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08		37035618	206163755	10	7623											
NCKAP5	344148	broad.mit.edu	37	chr2	133541700	133541700	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	caatggcaggccttgaccgtGaccctggagtctgactcttg	12	12	2	3			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr2:133541700G>A	uc002ttp.2	-	14	3058	c.2684C>T	c.(2683-2685)TCA>TTA	p.S895L	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	895							protein binding				0						CCTTGACCGTGACCCTGGAGT	0.607													A	133541700	A	A	133541700	3	1	112	1	0	0	0	0	1	0	0	0	10223	1294	45	3	3073	3	NCKAP5	2	133541700	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	96506082	133541700	109657673	11	7624											
NEB	4703	broad.mit.edu	37	chr2	152477436	152477436	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acttgatcagctcttacatcActggcaatatcccgagaggc	8	12	3	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr2:152477436A>G	uc010fnx.2	-	68	10019	c.9828T>C	c.(9826-9828)AGT>AGC	p.S3276S		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3276	Nebulin 89.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCTTACATCACTGGCAATAT	0.358													G	152477436	G	G	152477436	2	3	112	1	0	0	0	0	0	0	0	1	10302	156	6	4		4	NEB	2	152477436	Silent	SNP	A	TCGA-12-0616-01A-01D-1492-08	18935736	152477436	90721937	12	7625											
GAD1	2571	broad.mit.edu	37	chr2	171705817	171705817	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcctggggaggtgggctgCtcatgtccaggaagcaccgc	16	12	1	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr2:171705817C>T	uc002ugi.2	+	12	1563	c.1141C>T	c.(1141-1143)CTC>TTC	p.L381F	GAD1_uc010fqc.2_5'UTR	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	381					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGGTGGGCTGCTCATGTCCAG	0.532													T	171705817	T	T	171705817	3	4	112	1	0	0	0	0	1	0	0	0	6179	797	28	3	1224	3	GAD1	2	171705817	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08	19228381	171705817	71493556	13	7626											
DNAH1	25981	broad.mit.edu	37	chr3	52409985	52409986	+	Frame_Shift_Ins	INS	-	A	A													tctagatggactccttggagINSaaaaaagctaccgggagcgt							TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr3:52409985_52409986insA	uc011bef.1	+	46	7435_7436	c.7174_7175insA	c.(7174-7176)GAAfs	p.E2392fs		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2392	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACTCCTTGGAGAAAAAAGCTAC	0.609													A	52409986	A	A	52409985	7	5	112	1	0	1	1	0	0	0	0	0	4597	943	33	0	7352	0	DNAH1	3	52409985	Frame_Shift_Ins	INS	-	TCGA-12-0616-01A-01D-1492-08		52409985	145612445	14	7627											
CASR	846	broad.mit.edu	37	chr3	121980782	121980782	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggccagcgaggcctgggcCagctcctccctgatcgccat	12	17	0	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr3:121980782C>T	uc003eev.3	+	4	1272	c.900C>T	c.(898-900)GCC>GCT	p.A300A	CASR_uc003eew.3_Silent_p.A300A	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	300	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGGCCTGGGCCAGCTCCTCCC	0.602													T	121980782	T	T	121980782	2	4	112	1	0	0	0	0	0	0	0	1	2682	581	21	3		3	CASR	3	121980782	Silent	SNP	C	TCGA-12-0616-01A-01D-1492-08	69570797	121980782	76041648	15	7628											
FRYL	285527	broad.mit.edu	37	chr4	48559631	48559631	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttgctgtggggagaggttTtaagtccaccagctcgatgt	13	9	0	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr4:48559631T>G	uc003gyh.1	-	34	4569	c.3964A>C	c.(3964-3966)AAA>CAA	p.K1322Q	FRYL_uc003gyk.2_Missense_Mutation_p.K1322Q|FRYL_uc003gyg.1_Missense_Mutation_p.K18Q|FRYL_uc003gyi.1_Missense_Mutation_p.K211Q	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1322					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GGGAGAGGTTTTAAGTCCACC	0.512													G	48559631	G	G	48559631	3	3	112	1	0	0	0	0	1	0	0	0	6064	1850	64	5	5201	5	FRYL	4	48559631	Missense_Mutation	SNP	T	TCGA-12-0616-01A-01D-1492-08		48559631	142594645	16	7629											
KIT	3815	broad.mit.edu	37	chr4	55592080	55592080	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaaactcatctgggccaccGtttggaaagctagtggttca	10	10	3	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr4:55592080G>A	uc010igr.2	+	9	1491	c.1404G>A	c.(1402-1404)CCG>CCA	p.P468P	KIT_uc010igs.2_Silent_p.P468P|KIT_uc011bzw.1_5'Flank|KIT_uc010igt.1_5'Flank	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	468	Extracellular (Potential).|Ig-like C2-type 5.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.P468P(1)		soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTGGGCCACCGTTTGGAAAGC	0.453		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				A	55592080	A	A	55592080	2	1	112	1	0	0	0	0	0	0	0	1	8329	1132	40	1		1	KIT	4	55592080	Silent	SNP	G	TCGA-12-0616-01A-01D-1492-08	7032449	55592080	135562196	17	7630											
GPR98	84059	broad.mit.edu	37	chr5	90136528	90136528	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtattggatgtcatcctaaCgccagagacaggatctttaa	9	8	2	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr5:90136528C>T	uc003kju.2	+	78	16841	c.16745C>T	c.(16744-16746)ACG>ATG	p.T5582M	GPR98_uc003kjt.2_Missense_Mutation_p.T3288M|GPR98_uc003kjw.2_Missense_Mutation_p.T1243M	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5582	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTCATCCTAACGCCAGAGACA	0.423													T	90136528	T	T	90136528	3	4	112	1	0	0	0	0	1	0	0	0	6721	536	19	1	17055	1	GPR98	5	90136528	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08		90136528	90778732	18	7631											
OR2V2	285659	broad.mit.edu	37	chr5	180582407	180582407	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcctgggcctttgggataatCgatggcttgatccagatggt	13	8	0	2	rs149585637	byFrequency	TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr5:180582407C>T	uc011dhj.1	+	1	465	c.465C>T	c.(463-465)ATC>ATT	p.I155I		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGGGATAATCGATGGCTTGA	0.493													T	180582407	T	T	180582407	2	4	112	1	0	0	0	0	0	0	0	1	11031	874	31	2		2	OR2V2	5	180582407	Silent	SNP	C	TCGA-12-0616-01A-01D-1492-08	90445879	180582407	332853	19	7632											
TNXB	7148	broad.mit.edu	37	chr6	32013041	32013041	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtcagcactcctaggcgggGctcttcaggaggctcagggg	17	11	4	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr6:32013041G>T	uc003nzl.2	-	32	10865	c.10663C>A	c.(10663-10665)CCC>ACC	p.P3555T	TNXB_uc003nzg.1_5'UTR|TNXB_uc003nzh.1_Missense_Mutation_p.P24T	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3602	Fibronectin type-III 28.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCTAGGCGGGGCTCTTCAGGA	0.642													T	32013041	T	T	32013041	3	4	112	1	0	0	0	0	1	0	0	0	16343	1203	42	5	4102	5	TNXB	6	32013041	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08		32013041	139102026	20	7633											
UTRN	7402	broad.mit.edu	37	chr6	145115044	145115044	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcctgttacttcatgatgccAtccagatcccccggcagcta	8	15	1	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr6:145115044A>G	uc003qkt.2	+	62	9087	c.8995A>G	c.(8995-8997)ATC>GTC	p.I2999V		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2999	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TCATGATGCCATCCAGATCCC	0.498													G	145115044	G	G	145115044	3	3	112	1	0	0	0	0	1	0	0	0	17100	217	8	4	9241	4	UTRN	6	145115044	Missense_Mutation	SNP	A	TCGA-12-0616-01A-01D-1492-08	113102003	145115044	26000023	21	7634											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	112	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08		55233043	103905620	22	7635											
PHTF2	57157	broad.mit.edu	37	chr7	77552026	77552026	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactcattacgtcgtcatgtGgacaggacttctgaaggtgt	11	8	3	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr7:77552026G>A	uc003ugs.3	+	10	1176	c.1050G>A	c.(1048-1050)GTG>GTA	p.V350V	PHTF2_uc003ugo.3_Silent_p.V312V|PHTF2_uc003ugp.2_Silent_p.V312V|PHTF2_uc003ugq.3_Silent_p.V312V|PHTF2_uc010ldv.2_Silent_p.V312V|PHTF2_uc003ugr.3_Silent_p.V316V|PHTF2_uc003ugt.3_Silent_p.V316V|PHTF2_uc003ugu.3_Silent_p.V312V|PHTF2_uc003ugv.2_Silent_p.V175V|PHTF2_uc010ldw.1_Silent_p.V175V	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						GTCGTCATGTGGACAGGACTT	0.398													A	77552026	A	A	77552026	2	1	112	1	0	0	0	0	0	0	0	1	11863	1335	47	3		3	PHTF2	7	77552026	Silent	SNP	G	TCGA-12-0616-01A-01D-1492-08	22318983	77552026	81586637	23	7636											
TRRAP	8295	broad.mit.edu	37	chr7	98522846	98522846	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tggccatgatgagcctggagGacaacaagcacgcactctac	11	12	1	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr7:98522846G>C	uc003upp.2	+	22	3144	c.2935G>C	c.(2935-2937)GAC>CAC	p.D979H	TRRAP_uc011kis.1_Missense_Mutation_p.D979H|TRRAP_uc003upr.2_Missense_Mutation_p.D671H	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	979					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GAGCCTGGAGGACAACAAGCA	0.567													C	98522846	C	C	98522846	3	2	112	1	0	0	0	0	1	0	0	0	16598	1174	41	5	3017	5	TRRAP	7	98522846	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	20970820	98522846	60615817	24	7637											
PMPCB	9512	broad.mit.edu	37	chr7	102949403	102949403	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctttatcttaactagattcGtgtgagggatgacaagatgc	11	6	1	4			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr7:102949403G>A	uc003vbl.2	+	8	888	c.854G>A	c.(853-855)CGT>CAT	p.R285H	PMPCB_uc010liu.1_Missense_Mutation_p.R285H|PMPCB_uc003vbk.1_Missense_Mutation_p.R285H|PMPCB_uc003vbm.2_Missense_Mutation_p.R194H|PMPCB_uc010liv.2_Missense_Mutation_p.R191H|PMPCB_uc010liw.2_Missense_Mutation_p.R194H|PMPCB_uc011kll.1_Missense_Mutation_p.R180H|PMPCB_uc011klm.1_Missense_Mutation_p.R160H	NM_004279	NP_004270	O75439	MPPB_HUMAN	mitochondrial processing peptidase beta subunit	285					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4						AACTAGATTCGTGTGAGGGAT	0.408													A	102949403	A	A	102949403	3	1	112	1	0	0	0	0	1	0	0	0	12141	1145	40	1	884	1	PMPCB	7	102949403	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	4426557	102949403	56189260	25	7638											
FLNC	2318	broad.mit.edu	37	chr7	128494166	128494166	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaagcgcgaggtgcgggtggAggagtccacccaggtcggcg	19	10	0	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr7:128494166A>G	uc003vnz.3	+	40	6832	c.6623A>G	c.(6622-6624)GAG>GGG	p.E2208G	FLNC_uc003voa.3_Missense_Mutation_p.E2175G	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2208	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GTGCGGGTGGAGGAGTCCACC	0.687													G	128494166	G	G	128494166	3	3	112	1	0	0	0	0	1	0	0	0	5935	304	11	4	6781	4	FLNC	7	128494166	Missense_Mutation	SNP	A	TCGA-12-0616-01A-01D-1492-08	25544763	128494166	30644497	26	7639											
FRMD3	257019	broad.mit.edu	37	chr9	85958187	85958187	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgtcccttttaatctgAaggtataaaaggtatctgca	7	6	2	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr9:85958187A>G	uc004ams.1	-	5	592	c.390T>C	c.(388-390)CTT>CTC	p.L130L	FRMD3_uc004amr.1_Silent_p.L116L	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	130	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						TTTTAATCTGAAGGTATAAAA	0.448													G	85958187	G	G	85958187	2	3	112	1	0	0	0	0	0	0	0	1	6050	233	9	4		4	FRMD3	9	85958187	Silent	SNP	A	TCGA-12-0616-01A-01D-1492-08		85958187	55255244	27	7640											
LAMC3	10319	broad.mit.edu	37	chr9	133942520	133942520	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gcctgcacaacaccacgggtGaccactgtgagcactgtcag	11	14	1	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr9:133942520G>A	uc004caa.1	+	14	2619	c.2521G>A	c.(2521-2523)GAC>AAC	p.D841N		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	841	Laminin EGF-like 8.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CACCACGGGTGACCACTGTGA	0.642													A	133942520	A	A	133942520	3	1	112	1	0	0	0	0	1	0	0	0	8616	1290	45	3	2575	3	LAMC3	9	133942520	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	47984333	133942520	7270911	28	7641											
SURF4	6836	broad.mit.edu	37	chr9	136230531	136230531	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaaggcgttgaaatatacGttgatggcaaagagccacac	11	8	0	4			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr9:136230531G>A	uc004cdj.2	-	6	778	c.648C>T	c.(646-648)AAC>AAT	p.N216N	SURF4_uc011mda.1_Silent_p.N207N|SURF4_uc010nal.2_3'UTR|SURF4_uc011mdb.1_Silent_p.N173N|SURF4_uc011mdc.1_Silent_p.N173N|SURF4_uc011mdd.1_3'UTR	NM_033161	NP_149351	O15260	SURF4_HUMAN	surfeit 4	216	Helical; (Potential).					endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		TGAAATATACGTTGATGGCAA	0.478													A	136230531	A	A	136230531	2	1	112	1	0	0	0	0	0	0	0	1	15402	1136	40	1		1	SURF4	9	136230531	Silent	SNP	G	TCGA-12-0616-01A-01D-1492-08	2288011	136230531	4982900	29	7642											
OR52M1	119772	broad.mit.edu	37	chr11	4566682	4566682	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaaacttctgggaatcttcTggttcggtgcttgtgacatt	10	9	3	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr11:4566682T>C	uc010qyf.1	+	1	262	c.262T>C	c.(262-264)TGG>CGG	p.W88R		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGGAATCTTCTGGTTCGGTGC	0.517													C	4566682	C	C	4566682	3	2	112	1	0	0	0	0	1	0	0	0	11126	1580	55	4	264	4	OR52M1	11	4566682	Missense_Mutation	SNP	T	TCGA-12-0616-01A-01D-1492-08		4566682	130439834	30	7643											
OR56A3	390083	broad.mit.edu	37	chr11	5968802	5968802	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctctccctgctggacatcGtgctctgcctcactgtcatc	7	17	4	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr11:5968802G>A	uc010qzt.1	+	1	226	c.226G>A	c.(226-228)GTG>ATG	p.V76M		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGGACATCGTGCTCTGCCT	0.587													A	5968802	A	A	5968802	3	1	112	1	0	0	0	0	1	0	0	0	11134	1145	40	1	228	1	OR56A3	11	5968802	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	1402120	5968802	129037714	31	7644											
OR8H2	390151	broad.mit.edu	37	chr11	55872670	55872670	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggatgatattgataatccGcctggacctccagcttcaca	10	11	1	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr11:55872670G>A	uc010riy.1	+	1	152	c.152G>A	c.(151-153)CGC>CAC	p.R51H		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					TTGATAATCCGCCTGGACCTC	0.428										HNSCC(53;0.14)			A	55872670	A	A	55872670	3	1	112	1	0	0	0	0	1	0	0	0	11238	1087	38	1	154	1	OR8H2	11	55872670	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	49903868	55872670	79133846	32	7645											
SF3B2	10992	broad.mit.edu	37	chr11	65830517	65830517	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccatgctggtggctggggcaAacctccagtggatgagactg	15	10	0	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr11:65830517A>G	uc001ogy.1	+	17	2055	c.2015A>G	c.(2014-2016)AAA>AGA	p.K672R		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	672					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						GGCTGGGGCAAACCTCCAGTG	0.498													G	65830517	G	G	65830517	3	3	112	1	0	0	0	0	1	0	0	0	14151	14	1	4	2081	4	SF3B2	11	65830517	Missense_Mutation	SNP	A	TCGA-12-0616-01A-01D-1492-08	9957847	65830517	69175999	33	7646											
MMP12	4321	broad.mit.edu	37	chr11	102743841	102743841	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cataaaatttttctaagtatCtctggaaaaaaaaatacatt	3	5	2	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr11:102743841C>G	uc001phk.2	-	2	149	c.104G>C	c.(103-105)AGA>ACA	p.R35T		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	35					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TTCTAAGTATCTCTGGAAAAA	0.328													G	102743841	G	G	102743841	3	3	112	1	0	0	0	0	1	0	0	0	9651	927	32	5	1343	5	MMP12	11	102743841	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08	36913324	102743841	32262675	34	7647											
LPAR5	57121	broad.mit.edu	37	chr12	6729589	6729589	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcaccatcagcaccccgcGcacgcgatcgcgggcaggca	11	18	2	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr12:6729589G>A	uc009zer.2	-	2	1107	c.826C>T	c.(826-828)CGC>TGC	p.R276C	LPAR5_uc001qps.2_Missense_Mutation_p.R276C|LPAR5_uc010sff.1_Missense_Mutation_p.R276C	NM_001142961	NP_001136433	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	276	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2						AGCACCCCGCGCACGCGATCG	0.682													A	6729589	A	A	6729589	3	1	112	1	0	0	0	0	1	0	0	0	8908	1087	38	1	296	1	LPAR5	12	6729589	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08		6729589	127122306	35	7648											
PDE3A	5139	broad.mit.edu	37	chr12	20807040	20807040	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgcctggaaaatgggtggaaGacagcgatgagtcaggagat	16	5	1	3			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr12:20807040G>A	uc001reh.1	+	15	3107	c.3085G>A	c.(3085-3087)GAC>AAC	p.D1029N		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	1029	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ATGGGTGGAAGACAGCGATGA	0.478													A	20807040	A	A	20807040	3	1	112	1	0	0	0	0	1	0	0	0	11637	942	33	3	3143	3	PDE3A	12	20807040	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	14077451	20807040	113044855	36	7649											
KRT81	3887	broad.mit.edu	37	chr12	52685111	52685112	+	Frame_Shift_Ins	INS	-	G	G													cctccgcacacgctgtggctINSgccgaagcccccggtgaggc							TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr12:52685111_52685112insG	uc001sab.2	-	1	188_189	c.138_139insC	c.(136-141)GGCAGCfs	p.G46fs	KRT86_uc010snq.1_Intron|KRT86_uc009zmg.2_Intron|KRT81_uc001sac.2_Intron	NM_002281	NP_002272	Q14533	KRT81_HUMAN	keratin, hair, basic, 1	46_47	Head.					keratin filament	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACGCTGTGGCTGCCGAAGCCCC	0.748													G	52685112	G	G	52685111	7	5	112	1	0	1	1	0	0	0	0	0	8495	1580	55	0	1414	0	KRT81	12	52685111	Frame_Shift_Ins	INS	-	TCGA-12-0616-01A-01D-1492-08	31878071	52685111	81166784	37	7650											
NOC4L	79050	broad.mit.edu	37	chr12	132635897	132635897	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttcttccacctggctgacCtcttcctgtcctcctcgtga	7	17	2	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr12:132635897C>T	uc001ujz.1	+	11	1098	c.1057C>T	c.(1057-1059)CTC>TTC	p.L353F		NM_024078	NP_076983	Q9BVI4	NOC4L_HUMAN	nucleolar complex associated 4 homolog	353	Helical; (Potential).				rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)		CCTGGCTGACCTCTTCCTGTC	0.652													T	132635897	T	T	132635897	3	4	112	1	0	0	0	0	1	0	0	0	10515	681	24	3	1099	3	NOC4L	12	132635897	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08	79950786	132635897	1215998	38	7651											
PCCA	5095	broad.mit.edu	37	chr13	100809554	100809554	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttctaaggtacatccaggttAtggattcctttcagaaaaca	7	8	2	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr13:100809554A>G	uc001voo.2	+	6	466	c.428A>G	c.(427-429)TAT>TGT	p.Y143C	PCCA_uc010aga.2_Missense_Mutation_p.Y117C|PCCA_uc010tiz.1_Missense_Mutation_p.Y143C	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	143	Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	CATCCAGGTTATGGATTCCTT	0.318													G	100809554	G	G	100809554	3	3	112	1	0	0	0	0	1	0	0	0	11504	449	16	4	450	4	PCCA	13	100809554	Missense_Mutation	SNP	A	TCGA-12-0616-01A-01D-1492-08		100809554	14360324	39	7652											
NPAS3	64067	broad.mit.edu	37	chr14	34270129	34270129	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aagacgcccatggagatgctCtaccaccacgtgcaccggct	10	15	1	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr14:34270129C>T	uc001wru.2	+	12	2680	c.2616C>T	c.(2614-2616)CTC>CTT	p.L872L	NPAS3_uc001wrs.2_Silent_p.L859L|NPAS3_uc001wrt.2_Silent_p.L840L|NPAS3_uc001wrv.2_Silent_p.L842L	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	872					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		TGGAGATGCTCTACCACCACG	0.637													T	34270129	T	T	34270129	2	4	112	1	0	0	0	0	0	0	0	1	10564	900	32	3		3	NPAS3	14	34270129	Silent	SNP	C	TCGA-12-0616-01A-01D-1492-08		34270129	73079411	40	7653											
CACNG3	10368	broad.mit.edu	37	chr16	24366270	24366270	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacacaacgtcattctcagcGcgggcatcttttttgtctct	8	12	4	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr16:24366270G>A	uc002dmf.2	+	3	1612	c.412G>A	c.(412-414)GCG>ACG	p.A138T		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	138	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		CATTCTCAGCGCGGGCATCTT	0.572													A	24366270	A	A	24366270	3	1	112	1	0	0	0	0	1	0	0	0	2558	1087	38	1	422	1	CACNG3	16	24366270	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08		24366270	65988483	41	7654											
GJC1	10052	broad.mit.edu	37	chr17	42882694	42882694	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcccgaatccgtcgtcgGccatcatgcttaggtttggg	11	12	2	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr17:42882694G>A	uc002ihj.2	-	2	1003	c.492C>T	c.(490-492)GGC>GGT	p.G164G	GJC1_uc002ihk.2_Silent_p.G164G|GJC1_uc002ihl.2_Silent_p.G164G|GJC1_uc010czx.2_Silent_p.G164G|GJC1_uc010czy.1_Silent_p.G25G	NM_005497	NP_005488	P36383	CXG1_HUMAN	connexin 45	164	Cytoplasmic (Potential).				cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane					0		Prostate(33;0.0959)				TCCGTCGTCGGCCATCATGCT	0.468													A	42882694	A	A	42882694	2	1	112	1	0	0	0	0	0	0	0	1	6414	1190	42	3		3	GJC1	17	42882694	Silent	SNP	G	TCGA-12-0616-01A-01D-1492-08		42882694	38312516	42	7655											
DLX3	1747	broad.mit.edu	37	chr17	48072315	48072315	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tggcagctaagggagctggaGatgtcggtgaggatgctgct	18	6	0	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr17:48072315G>A	uc002ipy.2	-	1	274	c.48C>T	c.(46-48)ATC>ATT	p.I16I		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	16						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGGAGCTGGAGATGTCGGTGA	0.642													A	48072315	A	A	48072315	2	1	112	1	0	0	0	0	0	0	0	1	4572	932	33	3		3	DLX3	17	48072315	Silent	SNP	G	TCGA-12-0616-01A-01D-1492-08	5189621	48072315	33122895	43	7656											
ABCA6	23460	broad.mit.edu	37	chr17	67111007	67111007	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacattgaattgaggacagaCgccagttatctttctgattt	8	7	2	4			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr17:67111007C>T	uc002jhw.1	-	13	1853	c.1678G>A	c.(1678-1680)GTC>ATC	p.V560I	ABCA6_uc002jhx.1_Missense_Mutation_p.V13I	NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	560	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					TGAGGACAGACGCCAGTTATC	0.348													T	67111007	T	T	67111007	3	4	112	1	0	0	0	0	1	0	0	0	36	536	19	1	3283	1	ABCA6	17	67111007	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08	19038692	67111007	14084203	44	7657											
TMEM161A	54929	broad.mit.edu	37	chr19	19243312	19243312	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggtactccaggaagaagcGcaggactgtggggggcactc	16	10	0	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr19:19243312G>A	uc002nlg.2	-	5	322	c.292C>T	c.(292-294)CGC>TGC	p.R98C	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Intron|TMEM161A_uc002nli.2_Intron|TMEM161A_uc002nlj.2_5'UTR	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	98	Extracellular (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			AGGAAGAAGCGCAGGACTGTG	0.582													A	19243312	A	A	19243312	3	1	112	1	0	0	0	0	1	0	0	0	16073	1087	38	1	1179	1	TMEM161A	19	19243312	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08		19243312	39885671	45	7658											
ZNF229	7772	broad.mit.edu	37	chr19	44934110	44934110	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcaaaggtactcttggatgCgggggaaggtctgcatcgtc	14	8	3	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr19:44934110C>T	uc002oze.1	-	6	1280	c.846G>A	c.(844-846)CCG>CCA	p.P282P	ZNF229_uc010ejk.1_5'UTR|ZNF229_uc010ejl.1_Silent_p.P276P	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				CTCTTGGATGCGGGGGAAGGT	0.443													T	44934110	T	T	44934110	2	4	112	1	0	0	0	0	0	0	0	1	17779	755	27	1		1	ZNF229	19	44934110	Silent	SNP	C	TCGA-12-0616-01A-01D-1492-08	25690798	44934110	14194873	46	7659											
JOSD2	126119	broad.mit.edu	37	chr19	51009714	51009714	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagacaccgtccacctggcGcagggccacccagtgccgcc	12	18	0	1			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr19:51009714G>A	uc002psn.1	-	4	419	c.388C>T	c.(388-390)CGC>TGC	p.R130C	JOSD2_uc002pso.1_Missense_Mutation_p.R130C|JOSD2_uc002psp.1_Missense_Mutation_p.R130C|JOSD2_uc002psq.1_Missense_Mutation_p.R88C	NM_138334	NP_612207	Q8TAC2	JOS2_HUMAN	Josephin domain containing 2	130	Josephin.				protein deubiquitination		ubiquitin-specific protease activity				0		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0364)		TCCACCTGGCGCAGGGCCACC	0.701													A	51009714	A	A	51009714	3	1	112	1	0	0	0	0	1	0	0	0	7959	1087	38	1	186	1	JOSD2	19	51009714	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	6075604	51009714	8119269	47	7660											
CELSR1	9620	broad.mit.edu	37	chr22	46793605	46793605	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctgtagtcctcccaggcGtcgtggcagcggctattggg	15	12	0	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chr22:46793605G>A	uc003bhw.1	-	12	5667	c.5667C>T	c.(5665-5667)GAC>GAT	p.D1889D	CELSR1_uc011arc.1_Silent_p.D210D	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1889	Extracellular (Potential).|EGF-like 5; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCTCCCAGGCGTCGTGGCAGC	0.617													A	46793605	A	A	46793605	2	1	112	1	0	0	0	0	0	0	0	1	3221	1136	40	1		1	CELSR1	22	46793605	Silent	SNP	G	TCGA-12-0616-01A-01D-1492-08		46793605	4510961	48	7661											
USP11	8237	broad.mit.edu	37	chrX	47104414	47104414	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccacctctccctcacccccaGcccagccgtacattgctatc	4	22	2	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chrX:47104414G>C	uc004dhp.2	+	16	2216	c.2216_splice	c.e16-1	p.A739_splice	USP11_uc004dhq.2_Splice_Site_p.A465_splice	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11						protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CTCACCCCCAGCCCAGCCGTA	0.567													C	47104414	C	C	47104414	5	2	112	1	0	0	0	0	0	0	1	0	17039	985	34	5	2277	5	USP11	23	47104414	Splice_Site	SNP	G	TCGA-12-0616-01A-01D-1492-08		47104414	108166146	49	7662											
HUWE1	10075	broad.mit.edu	37	chrX	53576344	53576344	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctcagtactcggtgtagaCggctagtattgagctttggc	12	8	1	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chrX:53576344C>T	uc004dsp.2	-	67	10013	c.9611G>A	c.(9610-9612)CGT>CAT	p.R3204H	HUWE1_uc004dsn.2_Missense_Mutation_p.R2012H	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3204					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCGGTGTAGACGGCTAGTATT	0.557													T	53576344	T	T	53576344	3	4	112	1	0	0	0	0	1	0	0	0	7461	536	19	1	3585	1	HUWE1	23	53576344	Missense_Mutation	SNP	C	TCGA-12-0616-01A-01D-1492-08	6471930	53576344	101694216	50	7663											
DCAF12L1	139170	broad.mit.edu	37	chrX	125686329	125686329	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagctccagttggcgctccGtcagcagctcgggcagcctc	12	17	1	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chrX:125686329G>A	uc004eul.2	-	1	514	c.263C>T	c.(262-264)ACG>ATG	p.T88M		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	88										skin(3)|ovary(1)	4						TTGGCGCTCCGTCAGCAGCTC	0.657													A	125686329	A	A	125686329	3	1	112	1	0	0	0	0	1	0	0	0	4264	1145	40	1	1132	1	DCAF12L1	23	125686329	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	72109985	125686329	29584231	51	7664											
MAGEC1	9947	broad.mit.edu	37	chrX	140995245	140995245	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgagagtgctcctgagggGgaggattccctgtctcctct	13	12	2	2			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chrX:140995245G>A	uc004fbt.2	+	4	2341	c.2055G>A	c.(2053-2055)GGG>GGA	p.G685G	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	685							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCTGAGGGGGAGGATTCCC	0.577										HNSCC(15;0.026)			A	140995245	A	A	140995245	2	1	112	1	0	0	0	0	0	0	0	1	9180	1219	43	3		3	MAGEC1	23	140995245	Silent	SNP	G	TCGA-12-0616-01A-01D-1492-08	15308916	140995245	14275315	52	7665											
HAUS7	55559	broad.mit.edu	37	chrX	152735936	152735936	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccgaacacctccacagccGccctggacacgctgctgtcg	9	19	0	0			TCGA-12-0616-01A-01D-1492-08	TCGA-12-0616-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0e2fed7-38bd-48d8-a786-ac574c9fa5be	a5090d08-0c69-4ced-be5a-4dd0b633885f	g.chrX:152735936G>A	uc004fho.1	-	1	668	c.110C>T	c.(109-111)GCG>GTG	p.A37V	HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA|HAUS7_uc004fhn.1_Missense_Mutation_p.A37V|HAUS7_uc004fhp.1_RNA|HAUS7_uc011myq.1_RNA	NM_017518	NP_059988	Q99871	HAUS7_HUMAN	HAUS augmin-like complex subunit 7	37					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding				0						CTCCACAGCCGCCCTGGACAC	0.726													A	152735936	A	A	152735936	3	1	112	1	0	0	0	0	1	0	0	0	6971	1087	38	1	1036	1	HAUS7	23	152735936	Missense_Mutation	SNP	G	TCGA-12-0616-01A-01D-1492-08	11740691	152735936	2534624	53	7666											
COL16A1	1307	broad.mit.edu	37	chr1	32164172	32164172	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagtagtgtcagcaccaggGcaaactcctccgggagaccc	12	14	1	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr1:32164172G>A	uc001btk.1	-	5	667	c.302C>T	c.(301-303)GCC>GTC	p.A101V	COL16A1_uc001btj.1_5'UTR|COL16A1_uc001btl.3_Missense_Mutation_p.A101V	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	101	TSP N-terminal.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CAGCACCAGGGCAAACTCCTC	0.567													A	32164172	A	A	32164172	3	1	113	1	0	0	0	0	1	0	0	0	3673	1203	42	3	4780	3	COL16A1	1	32164172	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08		32164172	217086449	1	7667											
KLF17	128209	broad.mit.edu	37	chr1	44595136	44595136	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagcactttcctcacagcGcagagatgctggggtcccct	10	14	2	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr1:44595136G>A	uc001clp.2	+	2	251	c.193G>A	c.(193-195)GCA>ACA	p.A65T	KLF17_uc009vxf.1_Missense_Mutation_p.A28T	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	65					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TCCTCACAGCGCAGAGATGCT	0.557													A	44595136	A	A	44595136	3	1	113	1	0	0	0	0	1	0	0	0	8345	1087	38	1	199	1	KLF17	1	44595136	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	12430964	44595136	204655485	2	7668											
FLG2	388698	broad.mit.edu	37	chr1	152324215	152324215	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtcctggaccctctctgtGtggactgtccatgaccagag	11	12	1	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr1:152324215G>A	uc001ezw.3	-	3	6120	c.6047C>T	c.(6046-6048)ACA>ATA	p.T2016I	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2016	Filaggrin 9.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTCTCTGTGTGGACTGTCC	0.522													A	152324215	A	A	152324215	3	1	113	1	0	0	0	0	1	0	0	0	5923	1377	48	3	1132	3	FLG2	1	152324215	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	107729079	152324215	96926406	3	7669											
SPTA1	6708	broad.mit.edu	37	chr1	158585037	158585037	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgttgctccaggttgtgttGcatccgcaacccaagctggt	11	12	0	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr1:158585037G>A	uc001fst.1	-	48	6956	c.6757C>T	c.(6757-6759)CAA>TAA	p.Q2253*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2253	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGGTTGTGTTGCATCCGCAAC	0.537													A	158585037	A	A	158585037	4	1	113	1	0	0	0	0	0	1	0	0	15115	1328	46	3	522	3	SPTA1	1	158585037	Nonsense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	6260822	158585037	90665584	4	7670											
TNFSF4	7292	broad.mit.edu	37	chr1	173155865	173155865	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctggtaatgaaggctaatGttgacttcctgggagaagta	12	5	1	3			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr1:173155865G>A	uc001giw.2	-	3	498	c.342C>T	c.(340-342)AAC>AAT	p.N114N	TNFSF4_uc001giv.2_Silent_p.N64N	NM_003326	NP_003317	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily,	114	Extracellular (Potential).				acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			central_nervous_system(1)	1						GAAGGCTAATGTTGACTTCCT	0.468													A	173155865	A	A	173155865	2	1	113	1	0	0	0	0	0	0	0	1	16307	1368	48	3		3	TNFSF4	1	173155865	Silent	SNP	G	TCGA-12-0618-01A-01D-1492-08	14570828	173155865	76094756	5	7671											
IGFN1	91156	broad.mit.edu	37	chr1	201191952	201191952	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttcgtgtgcccgtctccttTgaagtgagtgtacctgcagg	13	10	1	2	rs146807711		TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr1:201191952T>G	uc001gwc.2	+	9	2539	c.1767T>G	c.(1765-1767)TTT>TTG	p.F589L	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CCGTCTCCTTTGAAGTGAGTG	0.572											OREG0014073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	201191952	G	G	201191952	3	3	113	1	0	0	0	0	1	0	0	0	7590	1809	63	5	10361	5	IGFN1	1	201191952	Missense_Mutation	SNP	T	TCGA-12-0618-01A-01D-1492-08	28036087	201191952	48058669	6	7672											
LIN9	286826	broad.mit.edu	37	chr1	226420896	226420896	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcctccttctgctagacacTaaagggaaaaaaatttcaaa	5	10	2	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr1:226420896T>C	uc001hqa.2	-	14	1784	c.1474_splice	c.e14-1	p.C492_splice	LIN9_uc001hqb.2_Splice_Site_p.C457_splice|LIN9_uc001hqc.2_Splice_Site_p.C424_splice|LIN9_uc009xel.1_Intron	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog						cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		TGCTAGACACTAAAGGGAAAA	0.294													C	226420896	C	C	226420896	5	2	113	1	0	0	0	0	0	0	1	0	8813	1536	53	4	212	4	LIN9	1	226420896	Splice_Site	SNP	T	TCGA-12-0618-01A-01D-1492-08	25228944	226420896	22829725	7	7673											
TRIB2	28951	broad.mit.edu	37	chr2	12858629	12858629	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttgtatcgggaaatacttaTtgttggaacctctggaggga	12	6	1	0	rs144421263	byFrequency	TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr2:12858629T>C	uc002rbv.3	+	1	1632	c.196T>C	c.(196-198)TTG>CTG	p.L66L	TRIB2_uc010yjp.1_Intron	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	66	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GAAATACTTATTGTTGGAACC	0.577											OREG0014450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	12858629	C	C	12858629	2	2	113	1	0	0	0	0	0	0	0	1	16480	1490	52	4		4	TRIB2	2	12858629	Silent	SNP	T	TCGA-12-0618-01A-01D-1492-08		12858629	230340744	8	7674											
IFT172	26160	broad.mit.edu	37	chr2	27682592	27682592	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atacctggcttcgatgtagtGattaatggctgcatcaagct	10	8	1	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr2:27682592G>T	uc002rku.2	-	24	2677	c.2626C>A	c.(2626-2628)CAC>AAC	p.H876N		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	876	TPR 4.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TCGATGTAGTGATTAATGGCT	0.522													T	27682592	T	T	27682592	3	4	113	1	0	0	0	0	1	0	0	0	7557	1290	45	5	2723	5	IFT172	2	27682592	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	14823963	27682592	215516781	9	7675											
PMS1	5378	broad.mit.edu	37	chr2	190728600	190728600	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccagcgcatggaatttggCccagaagcacaagttaaaaa	9	10	0	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr2:190728600C>T	uc002urh.3	+	10	2517	c.1988C>T	c.(1987-1989)GCC>GTC	p.A663V	PMS1_uc010zga.1_3'UTR|PMS1_uc010zgb.1_Missense_Mutation_p.A602V|PMS1_uc002urk.3_Missense_Mutation_p.A624V|PMS1_uc002uri.3_Intron|PMS1_uc010zgc.1_Missense_Mutation_p.A487V|PMS1_uc010zgd.1_Missense_Mutation_p.A487V|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Missense_Mutation_p.A624V|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Intron|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_Missense_Mutation_p.A331V	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	663					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			TGGAATTTGGCCCAGAAGCAC	0.363			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					T	190728600	T	T	190728600	3	4	113	1	0	0	0	0	1	0	0	0	12142	739	26	3	2022	3	PMS1	2	190728600	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	163046008	190728600	52470773	10	7676											
AOX1	316	broad.mit.edu	37	chr2	201523898	201523898	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaaattcaggtggtcagccGtgaattaagaatgccaatgt	10	6	2	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr2:201523898G>A	uc002uvx.2	+	28	3283	c.3182G>A	c.(3181-3183)CGT>CAT	p.R1061H	AOX1_uc010zhf.1_Missense_Mutation_p.R617H|AOX1_uc010fsu.2_Missense_Mutation_p.R427H	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	1061					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTGGTCAGCCGTGAATTAAGA	0.453													A	201523898	A	A	201523898	3	1	113	1	0	0	0	0	1	0	0	0	729	1145	40	1	3292	1	AOX1	2	201523898	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	10795298	201523898	41675475	11	7677											
ABCA12	26154	broad.mit.edu	37	chr2	215843155	215843156	+	Frame_Shift_Ins	INS	-	T	T													gctcaagactcatagcactaINStttttttgtgactctttggt							TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr2:215843155_215843156insT	uc002vew.2	-	33	5232_5233	c.5012_5013insA	c.(5011-5013)AATfs	p.N1671fs	ABCA12_uc002vev.2_Frame_Shift_Ins_p.N1353fs|ABCA12_uc010zjn.1_Frame_Shift_Ins_p.N598fs	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1671					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCATAGCACTATTTTTTTGTGA	0.376													T	215843156	T	T	215843155	7	5	113	1	0	1	1	0	0	0	0	0	30	446	16	0	2858	0	ABCA12	2	215843155	Frame_Shift_Ins	INS	-	TCGA-12-0618-01A-01D-1492-08	14319257	215843155	27356218	12	7678											
NEU2	4759	broad.mit.edu	37	chr2	233899564	233899564	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggtgcctacctcaacccgCgacctccagcccctgaggcc	10	19	1	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr2:233899564C>T	uc010zmn.1	+	2	940	c.940C>T	c.(940-942)CGA>TGA	p.R314*		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	314							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CCTCAACCCGCGACCTCCAGC	0.692													T	233899564	T	T	233899564	4	4	113	1	0	0	0	0	0	1	0	0	10342	760	27	1	946	1	NEU2	2	233899564	Nonsense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	18056409	233899564	9299809	13	7679											
COL6A3	1293	broad.mit.edu	37	chr2	238280769	238280769	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcctcagccgctgcaccgcGttctgcacttcatccttgct	9	17	3	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr2:238280769G>A	uc002vwl.2	-	9	4176	c.3891C>T	c.(3889-3891)AAC>AAT	p.N1297N	COL6A3_uc002vwo.2_Silent_p.N1091N|COL6A3_uc010znj.1_Silent_p.N690N|COL6A3_uc002vwq.2_Silent_p.N1091N|COL6A3_uc002vwr.2_Silent_p.N890N	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1297	VWFA 7.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.N1297N(1)		ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCTGCACCGCGTTCTGCACTT	0.617													A	238280769	A	A	238280769	2	1	113	1	0	0	0	0	0	0	0	1	3701	1136	40	1		1	COL6A3	2	238280769	Silent	SNP	G	TCGA-12-0618-01A-01D-1492-08	4381205	238280769	4918604	14	7680											
NEU4	129807	broad.mit.edu	37	chr2	242758284	242758284	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gagatttccttttgtacattCtccctgcgtgaggtcctgga	10	10	1	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr2:242758284C>G	uc010fzr.2	+	4	1451	c.1365C>G	c.(1363-1365)TTC>TTG	p.F455L	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Missense_Mutation_p.F455L|NEU4_uc002wcn.1_Missense_Mutation_p.F467L|NEU4_uc002wco.1_Missense_Mutation_p.F455L|NEU4_uc002wcp.1_Missense_Mutation_p.F467L	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	455						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		TTTGTACATTCTCCCTGCGTG	0.642													G	242758284	G	G	242758284	3	3	113	1	0	0	0	0	1	0	0	0	10344	912	32	5	1418	5	NEU4	2	242758284	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	4477515	242758284	441089	15	7681											
ATP2B2	491	broad.mit.edu	37	chr3	10413708	10413708	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcacaggcatccaggtggcGtaccaggttgttgtccttca	11	12	2	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr3:10413708G>A	uc003bvt.2	-	12	1883	c.1444C>T	c.(1444-1446)CGC>TGC	p.R482C	ATP2B2_uc003bvv.2_Missense_Mutation_p.R437C|ATP2B2_uc003bvw.2_Missense_Mutation_p.R437C|ATP2B2_uc010hdo.2_Missense_Mutation_p.R187C	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	482	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TCCAGGTGGCGTACCAGGTTG	0.587													A	10413708	A	A	10413708	3	1	113	1	0	0	0	0	1	0	0	0	1140	1145	40	1	2335	1	ATP2B2	3	10413708	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08		10413708	187608722	16	7682											
RRP9	9136	broad.mit.edu	37	chr3	51969702	51969702	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgggtgcctctgcggaatgCcagaccctaagggtgcatgg	16	10	1	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr3:51969702C>T	uc003dbw.1	-	9	781	c.742G>A	c.(742-744)GCA>ACA	p.A248T		NM_004704	NP_004695	O43818	U3IP2_HUMAN	RNA, U3 small nucleolar interacting protein 2	248	WD 3.				rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		CTGCGGAATGCCAGACCCTAA	0.592													T	51969702	T	T	51969702	3	4	113	1	0	0	0	0	1	0	0	0	13691	739	26	3	713	3	RRP9	3	51969702	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	41555994	51969702	146052728	17	7683											
RETNLB	84666	broad.mit.edu	37	chr3	108474644	108474644	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcaggtcaggtggcagcagCgggcagtggtccagtccacc	16	12	2	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr3:108474644C>T	uc003dxh.2	-	3	415	c.317G>A	c.(316-318)CGC>CAC	p.R106H		NM_032579	NP_115968	Q9BQ08	RETNB_HUMAN	resistin like beta precursor	106					cell proliferation	extracellular region	hormone activity			skin(1)	1						GTGGCAGCAGCGGGCAGTGGT	0.552													T	108474644	T	T	108474644	3	4	113	1	0	0	0	0	1	0	0	0	13237	768	27	1	22	1	RETNLB	3	108474644	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	56504942	108474644	89547786	18	7684											
SEC62	7095	broad.mit.edu	37	chr3	169694809	169694809	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agaggaagctttatttacaaCcagggagtctgtggttgact	12	6	1	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr3:169694809C>A	uc003fgg.2	+	3	252	c.221C>A	c.(220-222)ACC>AAC	p.T74N	SEC62_uc003fgh.2_Missense_Mutation_p.T74N	NM_003262	NP_003253	Q99442	SEC62_HUMAN	translocation protein 1	74	Cytoplasmic (Potential).				cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			ovary(1)	1						TTATTTACAACCAGGGAGTCT	0.348													A	169694809	A	A	169694809	3	1	113	1	0	0	0	0	1	0	0	0	14004	507	18	5	231	5	SEC62	3	169694809	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	61220165	169694809	28327621	19	7685											
DKK2	27123	broad.mit.edu	37	chr4	107846994	107846994	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggggcagcacatgccatctCggtggcagcgcttctttttt	12	11	2	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr4:107846994C>T	uc003hyi.2	-	2	1040	c.335G>A	c.(334-336)CGA>CAA	p.R112Q	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Missense_Mutation_p.R112Q	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	112	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space		p.R112G(1)		ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CATGCCATCTCGGTGGCAGCG	0.498													T	107846994	T	T	107846994	3	4	113	1	0	0	0	0	1	0	0	0	4545	884	31	2	456	2	DKK2	4	107846994	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08		107846994	83307282	20	7686											
SH3RF2	153769	broad.mit.edu	37	chr5	145393517	145393517	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtccattctccttcagggCgccatatggtagagatcagc	11	11	3	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr5:145393517C>T	uc003lnt.2	+	5	1190	c.952C>T	c.(952-954)CGC>TGC	p.R318C	SH3RF2_uc011dbl.1_Missense_Mutation_p.R318C	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	318							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCTTCAGGGCGCCATATGGT	0.577													T	145393517	T	T	145393517	3	4	113	1	0	0	0	0	1	0	0	0	14259	768	27	1	966	1	SH3RF2	5	145393517	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08		145393517	35521743	21	7687											
OR14J1	442191	broad.mit.edu	37	chr6	29275286	29275286	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtggaccttgtattctccGtattctatactgtgatacct	7	10	2	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr6:29275286G>A	uc011dln.1	+	1	820	c.820G>A	c.(820-822)GTA>ATA	p.V274I		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGTATTCTCCGTATTCTATAC	0.443													A	29275286	A	A	29275286	3	1	113	1	0	0	0	0	1	0	0	0	10948	1145	40	1	822	1	OR14J1	6	29275286	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08		29275286	141839781	22	7688											
HLA-DOA	3111	broad.mit.edu	37	chr6	32975995	32975995	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaactggcccgaggcgccGtaagactggtagaaggcggg	18	9	0	3			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr6:32975995G>A	uc003ocr.2	-	2	202	c.126C>T	c.(124-126)TAC>TAT	p.Y42Y	HLA-DOA_uc010juj.2_Silent_p.Y12Y|HLA-DOA_uc010jui.2_Silent_p.Y42Y	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	42	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						CCGAGGCGCCGTAAGACTGGT	0.542													A	32975995	A	A	32975995	2	1	113	1	0	0	0	0	0	0	0	1	7200	1140	40	1		1	HLA-DOA	6	32975995	Silent	SNP	G	TCGA-12-0618-01A-01D-1492-08	3700709	32975995	138139072	23	7689											
CUL9	23113	broad.mit.edu	37	chr6	43163923	43163923	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agagagatcttcgccagcatCgactcagccacacgcccggg	11	15	2	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr6:43163923C>A	uc003ouk.2	+	10	2580	c.2505C>A	c.(2503-2505)ATC>ATA	p.I835I	CUL9_uc003oul.2_Silent_p.I835I|CUL9_uc010jyk.2_5'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	835					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						TCGCCAGCATCGACTCAGCCA	0.567													A	43163923	A	A	43163923	2	1	113	1	0	0	0	0	0	0	0	1	4061	874	31	5		5	CUL9	6	43163923	Silent	SNP	C	TCGA-12-0618-01A-01D-1492-08	10187928	43163923	127951144	24	7690											
CRISP3	10321	broad.mit.edu	37	chr6	49696554	49696554	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagttactatagagatcttcGtacttgcaaccattggctgg	9	9	1	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr6:49696554G>A	uc003ozs.2	-	8	642	c.627C>T	c.(625-627)TAC>TAT	p.Y209Y		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	209					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AGAGATCTTCGTACTTGCAAC	0.358													A	49696554	A	A	49696554	2	1	113	1	0	0	0	0	0	0	0	1	3881	1140	40	1		1	CRISP3	6	49696554	Silent	SNP	G	TCGA-12-0618-01A-01D-1492-08	6532631	49696554	121418513	25	7691											
ORC3L	23595	broad.mit.edu	37	chr6	88318866	88318866	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gactacttctagccaatggcAgtctcctcctgttgtcgtta	8	12	2	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr6:88318866A>T	uc003pmh.2	+	7	676	c.632A>T	c.(631-633)CAG>CTG	p.Q211L	ORC3L_uc011dzl.1_Missense_Mutation_p.Q211L|ORC3L_uc011dzm.1_Missense_Mutation_p.Q211L|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Missense_Mutation_p.Q211L|ORC3L_uc003pmi.2_Missense_Mutation_p.Q211L|ORC3L_uc011dzo.1_Missense_Mutation_p.Q68L|ORC3L_uc011dzp.1_Missense_Mutation_p.Q68L	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	211					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		AGCCAATGGCAGTCTCCTCCT	0.398													T	88318866	T	T	88318866	3	4	113	1	0	0	0	0	1	0	0	0	11263	188	7	5	658	5	ORC3L	6	88318866	Missense_Mutation	SNP	A	TCGA-12-0618-01A-01D-1492-08	38622312	88318866	82796201	26	7692											
ARID1B	57492	broad.mit.edu	37	chr6	157522507	157522507	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccccacatcccaggtcacCgggccaccaccccaaccacc	6	23	1	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr6:157522507C>T	uc003qqn.2	+	18	4877	c.4725C>T	c.(4723-4725)ACC>ACT	p.T1575T	ARID1B_uc003qqo.2_Silent_p.T1535T|ARID1B_uc003qqp.2_Silent_p.T1522T	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1580	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCCAGGTCACCGGGCCACCAC	0.547													T	157522507	T	T	157522507	2	4	113	1	0	0	0	0	0	0	0	1	914	639	23	2		2	ARID1B	6	157522507	Silent	SNP	C	TCGA-12-0618-01A-01D-1492-08	69203641	157522507	13592560	27	7693											
OSBPL3	26031	broad.mit.edu	37	chr7	24874215	24874215	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctcgttcagctccaccgGcatggccaccttggacaggt	13	14	1	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr7:24874215G>A	uc003sxf.2	-	15	2041	c.1636C>T	c.(1636-1638)CCG>TCG	p.P546S	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.P510S|OSBPL3_uc003sxh.2_Missense_Mutation_p.P515S|OSBPL3_uc003sxi.2_Missense_Mutation_p.P479S|OSBPL3_uc003sxj.1_Missense_Mutation_p.P275S|OSBPL3_uc003sxk.1_Missense_Mutation_p.P244S	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	546					lipid transport		lipid binding|protein binding			skin(1)	1						AGCTCCACCGGCATGGCCACC	0.632													A	24874215	A	A	24874215	3	1	113	1	0	0	0	0	1	0	0	0	11279	1203	42	3	1063	3	OSBPL3	7	24874215	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08		24874215	134264448	28	7694											
NSUN5	55695	broad.mit.edu	37	chr7	72721702	72721702	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggcccaacagagccttccatCggcccccaccccctcgaaag	8	20	0	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr7:72721702C>T	uc003txw.2	-	3	305	c.269G>A	c.(268-270)CGA>CAA	p.R90Q	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Missense_Mutation_p.R90Q|NSUN5_uc003txx.2_Intron|NSUN5_uc011kev.1_Missense_Mutation_p.R90Q	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	90							methyltransferase activity				0		Lung NSC(55;0.163)				AGCCTTCCATCGGCCCCCACC	0.552													T	72721702	T	T	72721702	3	4	113	1	0	0	0	0	1	0	0	0	10681	884	31	2	1184	2	NSUN5	7	72721702	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	47847487	72721702	86416961	29	7695											
ABCB4	5244	broad.mit.edu	37	chr7	87079357	87079357	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagagcctcttctgccacggCgcctgcttttgcataagcag	10	14	2	1	rs147998447	byFrequency	TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr7:87079357C>T	uc003uiv.1	-	8	836	c.760G>A	c.(760-762)GCC>ACC	p.A254T	ABCB4_uc003uiw.1_Missense_Mutation_p.A254T|ABCB4_uc003uix.1_Missense_Mutation_p.A254T	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	254	ABC transmembrane type-1 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TCTGCCACGGCGCCTGCTTTT	0.478													T	87079357	T	T	87079357	3	4	113	1	0	0	0	0	1	0	0	0	43	768	27	1	3184	1	ABCB4	7	87079357	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	14357655	87079357	72059306	30	7696											
ORAI2	80228	broad.mit.edu	37	chr7	102086975	102086975	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcaggtggccatggtggagGtgcagctggagacgcagtac	18	9	0	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr7:102086975G>A	uc010lhz.1	+	4	476	c.241G>A	c.(241-243)GTG>ATG	p.V81M	ORAI2_uc003uzj.2_Missense_Mutation_p.V81M|ORAI2_uc003uzk.2_Missense_Mutation_p.V81M|ORAI2_uc011kks.1_Missense_Mutation_p.V4M	NM_001126340	NP_001119812	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator	81	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|kidney(1)	2						CATGGTGGAGGTGCAGCTGGA	0.677													A	102086975	A	A	102086975	3	1	113	1	0	0	0	0	1	0	0	0	11258	1261	44	3	247	3	ORAI2	7	102086975	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	15007618	102086975	57051688	31	7697											
SLC26A3	1811	broad.mit.edu	37	chr7	107431671	107431671	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaccatcatactcagaatcGgaaacggacctaattaacag	6	12	2	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr7:107431671G>A	uc003ver.2	-	5	603	c.392C>T	c.(391-393)CCG>CTG	p.P131L	SLC26A3_uc003ves.2_Missense_Mutation_p.P96L	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	131	Helical; (Potential).		P -> R (in DIAR1).		excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						ACTCAGAATCGGAAACGGACC	0.428													A	107431671	A	A	107431671	3	1	113	1	0	0	0	0	1	0	0	0	14518	1116	39	2	1970	2	SLC26A3	7	107431671	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	5344696	107431671	51706992	32	7698											
EZH2	2146	broad.mit.edu	37	chr7	148515006	148515009	+	Frame_Shift_Del	DEL	TTCT	-	-													tcatctttcttctcttcttcTtctttatcattgttctctcc							TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr7:148515006_148515009delTTCT	uc003wfd.1	-	10	1351_1354	c.1185_1188delAGAA	c.(1183-1188)AAAGAAfs	p.K395fs	EZH2_uc011kug.1_Frame_Shift_Del_p.K386fs|EZH2_uc003wfb.1_Frame_Shift_Del_p.K400fs|EZH2_uc003wfc.1_Frame_Shift_Del_p.K356fs|EZH2_uc011kuh.1_Frame_Shift_Del_p.K386fs|EZH2_uc011kui.1_Frame_Shift_Del_p.K395fs|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	395_396					negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding	p.E401fs*22(1)		haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TCTCTTCTTCTTCTTTATCATTGT	0.456			Mis		DLBCL								-	148515009	-	-	148515006	7	5	113	1	0	1	0	1	0	0	0	0	5334	1606	56	0	1096	0	EZH2	7	148515006	Frame_Shift_Del	DEL	TTCT	TCGA-12-0618-01A-01D-1492-08	41083335	148515006	10623657	33	7699											
BMP1	649	broad.mit.edu	37	chr8	22069181	22069181	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatgacaccatcaccaaaaaAggtttccacctgcgatacac	6	13	1	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr8:22069181A>G	uc003xbg.2	+	20	3145	c.2901A>G	c.(2899-2901)AAA>AAG	p.K967K	BMP1_uc011kzc.1_Silent_p.K716K|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	967	CUB 5.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TCACCAAAAAAGGTTTCCACC	0.577													G	22069181	G	G	22069181	2	3	113	1	0	0	0	0	0	0	0	1	1456	69	3	4		4	BMP1	8	22069181	Silent	SNP	A	TCGA-12-0618-01A-01D-1492-08		22069181	124294841	34	7700											
EYA1	2138	broad.mit.edu	37	chr8	72156896	72156896	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tgaaaatcatttcttccattCgcagtccaagggaaactgaa	7	9	2	2	rs145219836	by1000genomes	TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr8:72156896C>A	uc003xys.3	-	11	1369	c.1082G>T	c.(1081-1083)CGA>CTA	p.R361L	EYA1_uc003xyr.3_Intron|EYA1_uc003xyt.3_Missense_Mutation_p.R328L|EYA1_uc010lzf.2_Missense_Mutation_p.R288L|EYA1_uc003xyu.2_Missense_Mutation_p.R361L|EYA1_uc011lfe.1_Missense_Mutation_p.R355L|EYA1_uc003xyv.2_Missense_Mutation_p.R239L	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	361					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity	p.R361L(1)		ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TTCTTCCATTCGCAGTCCAAG	0.323													A	72156896	A	A	72156896	3	1	113	1	0	0	0	0	1	0	0	0	5328	884	31	5	724	5	EYA1	8	72156896	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	50087715	72156896	74207126	35	7701											
DECR1	1666	broad.mit.edu	37	chr8	91031335	91031335	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcatgcaattcagtgtgatGtgagggatcctgatatggtt	12	5	2	3			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr8:91031335G>A	uc003yek.1	+	4	493	c.352G>A	c.(352-354)GTG>ATG	p.V118M	DECR1_uc011lgc.1_Missense_Mutation_p.V109M|DECR1_uc011lgd.1_RNA	NM_001359	NP_001350	Q16698	DECR_HUMAN	2,4-dienoyl CoA reductase 1 precursor	118					fatty acid beta-oxidation|protein homotetramerization	mitochondrial matrix|nucleus|plasma membrane	2,4-dienoyl-CoA reductase (NADPH) activity|NADPH binding|oxidoreductase activity, acting on NADH or NADPH				0			BRCA - Breast invasive adenocarcinoma(11;0.00953)			TCAGTGTGATGTGAGGGATCC	0.363													A	91031335	A	A	91031335	3	1	113	1	0	0	0	0	1	0	0	0	4382	1377	48	3	366	3	DECR1	8	91031335	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	18874439	91031335	55332687	36	7702											
PRDM12	59335	broad.mit.edu	37	chr9	133543671	133543671	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctggaggtggtccagatcGgcaccagcatcttctacaag	11	12	2	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr9:133543671G>A	uc004bzt.1	+	3	601	c.541G>A	c.(541-543)GGC>AGC	p.G181S		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	181	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GGTCCAGATCGGCACCAGCAT	0.582													A	133543671	A	A	133543671	3	1	113	1	0	0	0	0	1	0	0	0	12453	1116	39	2	551	2	PRDM12	9	133543671	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08		133543671	7669760	37	7703											
PTEN	5728	broad.mit.edu	37	chr10	89653779	89653780	+	Splice_Site	INS	-	AGAT	AGAT													tttccttaactaaagtactcINSagatatttatccaaacatta							TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr10:89653779_89653780insAGAT	uc001kfb.2	+	3	1111	c.80_splice	c.e3-2	p.Y27_splice		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTAAAGTACTCAGATATTTATC	0.312		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			AGAT	89653780	AGAT	AGAT	89653779	8	5	113	1	0	1	1	0	0	0	1	0	12738	841	29	0		0	PTEN	10	89653779	Splice_Site	INS	-	TCGA-12-0618-01A-01D-1492-08		89653779	45880968	38	7704											
HBG2	3048	broad.mit.edu	37	chr11	5275527	5275527	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atctcctggactcaccttgaAgttctcaggatccacatgca	7	13	3	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr11:5275527A>G	uc001mai.1	-	2	747	c.310T>C	c.(310-312)TTC>CTC	p.F104L	HBG2_uc001mak.1_RNA|HBG2_uc001maj.1_Missense_Mutation_p.F104L	NM_000559	NP_000550	P69892	HBG2_HUMAN	A-gamma globin	104					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCACCTTGAAGTTCTCAGGA	0.498													G	5275527	G	G	5275527	3	3	113	1	0	0	0	0	1	0	0	0	6983	72	3	4	141	4	HBG2	11	5275527	Missense_Mutation	SNP	A	TCGA-12-0618-01A-01D-1492-08		5275527	129730989	39	7705											
SPRYD5	84767	broad.mit.edu	37	chr11	55653609	55653610	+	Frame_Shift_Ins	INS	-	A	A													gttttgcaggaggagctcctINSaaaaaaaatgcagtctttat							TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr11:55653609_55653610insA	uc010rip.1	+	3	514_515	c.422_423insA	c.(421-423)CTAfs	p.L141fs	SPRYD5_uc010riq.1_5'UTR	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	141						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GAGGAGCTCCTAAAAAAAATGC	0.401													A	55653610	A	A	55653609	7	5	113	1	0	1	1	0	0	0	0	0	15110	1522	53	0	428	0	SPRYD5	11	55653609	Frame_Shift_Ins	INS	-	TCGA-12-0618-01A-01D-1492-08	50378082	55653609	79352907	40	7706											
INCENP	3619	broad.mit.edu	37	chr11	61898063	61898063	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcctctggccgcatcatctGtgagtctgggggcttggcag	15	11	4	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr11:61898063G>A	uc001nsw.1	+	4	1265	c.1063_splice	c.e4+1	p.C355_splice	INCENP_uc009ynv.2_Splice_Site_p.C355_splice|INCENP_uc009ynw.1_Splice_Site_p.C355_splice|INCENP_uc001nsx.1_Splice_Site_p.C355_splice	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa						chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						CGCATCATCTGTGAGTCTGGG	0.537													A	61898063	A	A	61898063	5	1	113	1	0	0	0	0	0	0	1	0	7733	1391	48	3	1074	3	INCENP	11	61898063	Splice_Site	SNP	G	TCGA-12-0618-01A-01D-1492-08	6244454	61898063	73108453	41	7707											
MYEOV	26579	broad.mit.edu	37	chr11	69063304	69063304	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caggaggcagaagacgtggaCgtgtcccgggccaggagggt	19	9	0	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr11:69063304C>A	uc001oov.2	+	3	837	c.387C>A	c.(385-387)GAC>GAA	p.D129E	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.D129E|MYEOV_uc001oow.2_Missense_Mutation_p.D71E	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	129											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		AAGACGTGGACGTGTCCCGGG	0.617													A	69063304	A	A	69063304	3	1	113	1	0	0	0	0	1	0	0	0	10025	535	19	5	393	5	MYEOV	11	69063304	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	7165241	69063304	65943212	42	7708											
VWF	7450	broad.mit.edu	37	chr12	6127617	6127617	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggagcctctcgggggagcGtctcaaagtcctggatgagg	16	10	2	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr12:6127617G>A	uc001qnn.1	-	28	5217	c.4967C>T	c.(4966-4968)ACG>ATG	p.T1656M	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1656	VWFA 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	TCGGGGGAGCGTCTCAAAGTC	0.632													A	6127617	A	A	6127617	3	1	113	1	0	0	0	0	1	0	0	0	17243	1145	40	1	3574	1	VWF	12	6127617	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08		6127617	127724278	43	7709											
MDM2	4193	broad.mit.edu	37	chr12	69229607	69229607	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atatatttttttcttgttttAggatcttgatgctggtgtaa	8	3	2	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr12:69229607A>G	uc001sui.2	+	9	972	c.685_splice	c.e9-2	p.D229_splice	MDM2_uc009zri.2_Splice_Site_p.D184_splice|MDM2_uc009zqx.2_Splice_Site_p.D174_splice|MDM2_uc009zqw.2_Intron|MDM2_uc001suk.2_Intron|MDM2_uc009zqy.1_Splice_Site_p.D218_splice|MDM2_uc001sun.3_Splice_Site_p.D48_splice|MDM2_uc009zqz.2_Splice_Site_p.D223_splice|MDM2_uc009zra.2_Splice_Site_p.D53_splice|MDM2_uc001sum.1_Intron|MDM2_uc009zrd.2_Splice_Site|MDM2_uc009zrc.2_Intron|MDM2_uc009zre.2_Intron|MDM2_uc009zrf.2_Intron|MDM2_uc001suo.2_Splice_Site_p.D23_splice|MDM2_uc009zrg.2_Intron|MDM2_uc009zrh.2_Splice_Site_p.D23_splice	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2						cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TTCTTGTTTTAGGATCTTGAT	0.398			A		sarcoma|glioma|colorectal|other								G	69229607	G	G	69229607	5	3	113	1	0	0	0	0	0	0	1	0	9413	434	15	4	717	4	MDM2	12	69229607	Splice_Site	SNP	A	TCGA-12-0618-01A-01D-1492-08	63101990	69229607	64622288	44	7710											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100491231	100491231	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagatgtgaactttgggtgGcatctgcctctattcttatc	9	9	3	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr12:100491231G>A	uc001tgq.2	-	6	810	c.581C>T	c.(580-582)GCC>GTC	p.A194V	UHRF1BP1L_uc001tgr.2_Missense_Mutation_p.A194V	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	194										ovary(2)	2						ACTTTGGGTGGCATCTGCCTC	0.353													A	100491231	A	A	100491231	3	1	113	1	0	0	0	0	1	0	0	0	16966	1203	42	3	3901	3	UHRF1BP1L	12	100491231	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	31261624	100491231	33360664	45	7711											
OAS2	4939	broad.mit.edu	37	chr12	113447043	113447043	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caataccaccttggaaagtgCcggtaaaagtcatctaaagg	9	9	2	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr12:113447043C>T	uc001tuj.2	+	10	2187	c.2047C>T	c.(2047-2049)CCG>TCG	p.P683S	OAS2_uc001tui.1_Missense_Mutation_p.P683S	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	683	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						TTGGAAAGTGCCGGTAAAAGT	0.458													T	113447043	T	T	113447043	3	4	113	1	0	0	0	0	1	0	0	0	10800	739	26	3	2156	3	OAS2	12	113447043	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	12955812	113447043	20404852	46	7712											
KIAA0564	23078	broad.mit.edu	37	chr13	42481750	42481750	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaaaaggctgtgcctgcaCggatctctcgtcgctgtttg	12	10	1	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr13:42481750C>T	uc001uyj.2	-	4	525	c.455G>A	c.(454-456)CGT>CAT	p.R152H	KIAA0564_uc001uyk.2_Missense_Mutation_p.R152H	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	152						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		TGTGCCTGCACGGATCTCTCG	0.458													T	42481750	T	T	42481750	3	4	113	1	0	0	0	0	1	0	0	0	8185	536	19	1	5434	1	KIAA0564	13	42481750	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08		42481750	72688128	47	7713											
TRIM13	10206	broad.mit.edu	37	chr13	50587073	50587073	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcattgtctttggtcctAccatgttcctagaatggtca	8	9	3	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr13:50587073A>T	uc001vdq.1	+	3	1310	c.997A>T	c.(997-999)ACC>TCC	p.T333S	DLEU2_uc001vdn.1_Intron|DLEU2_uc001vdo.1_Intron|KCNRG_uc001vdt.2_5'Flank|KCNRG_uc001vdu.2_5'Flank|TRIM13_uc001vdp.1_Missense_Mutation_p.T336S|TRIM13_uc001vdr.1_Missense_Mutation_p.T333S|TRIM13_uc001vds.1_Missense_Mutation_p.T333S	NM_052811	NP_434698	O60858	TRI13_HUMAN	ret finger protein 2 isoform 1	333	Helical; (Potential).				anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)		CTTTGGTCCTACCATGTTCCT	0.408													T	50587073	T	T	50587073	3	4	113	1	0	0	0	0	1	0	0	0	16485	391	14	5	1012	5	TRIM13	13	50587073	Missense_Mutation	SNP	A	TCGA-12-0618-01A-01D-1492-08	8105323	50587073	64582805	48	7714											
SLITRK6	84189	broad.mit.edu	37	chr13	86369237	86369237	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtggtaaaacttggaggagGttgttatttaaatacaggac	13	3	0	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr13:86369237G>T	uc001vll.1	-	2	1866	c.1407C>A	c.(1405-1407)AAC>AAA	p.N469K	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	469	Extracellular (Potential).|LRR 10.			N -> H (in Ref. 1).		integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CTTGGAGGAGGTTGTTATTTA	0.328													T	86369237	T	T	86369237	3	4	113	1	0	0	0	0	1	0	0	0	14747	1252	44	5	1122	5	SLITRK6	13	86369237	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	35782164	86369237	28800641	49	7715											
C14orf174	161394	broad.mit.edu	37	chr14	77843838	77843839	+	Frame_Shift_Ins	INS	-	TG	TG													cctgagaggcctgaactgccINStggacttcataaattgtatg							TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr14:77843838_77843839insTG	uc001xtq.1	+	1	77_78	c.77_78insTG	c.(76-78)CCTfs	p.P26fs	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	26											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		CCTGAACTGCCTGGACTTCATA	0.54													TG	77843839	TG	TG	77843838	7	5	113	1	0	1	1	0	0	0	0	0	1759	681	24	0	79	0	C14orf174	14	77843838	Frame_Shift_Ins	INS	-	TCGA-12-0618-01A-01D-1492-08		77843838	29505702	50	7716											
SERPINA11	256394	broad.mit.edu	37	chr14	94912764	94912764	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcagggaggaccagcagcGccaaggcatttcctctgtat	13	11	2	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr14:94912764G>A	uc001ydd.1	-	3	881	c.821C>T	c.(820-822)GCG>GTG	p.A274V		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	274					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		GACCAGCAGCGCCAAGGCATT	0.547													A	94912764	A	A	94912764	3	1	113	1	0	0	0	0	1	0	0	0	14088	1087	38	1	459	1	SERPINA11	14	94912764	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	17068926	94912764	12436776	51	7717											
GATM	2628	broad.mit.edu	37	chr15	45658329	45658329	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caatatgcatgggattgggaTctttaaaggagatgatatgc	12	4	1	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr15:45658329T>C	uc001zvc.2	-	6	1222	c.893A>G	c.(892-894)GAT>GGT	p.D298G	GATM_uc001zvb.2_Missense_Mutation_p.D169G|GATM_uc010uev.1_Missense_Mutation_p.D351G	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	298					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	GGGATTGGGATCTTTAAAGGA	0.428													C	45658329	C	C	45658329	3	2	113	1	0	0	0	0	1	0	0	0	6263	1435	50	4	394	4	GATM	15	45658329	Missense_Mutation	SNP	T	TCGA-12-0618-01A-01D-1492-08		45658329	56873063	52	7718											
PDILT	204474	broad.mit.edu	37	chr16	20370700	20370702	+	In_Frame_Del	DEL	CCA	-	-													tggaggtccctttggcttagCcaccaccaccaccacctcct							TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr16:20370700_20370702delCCA	uc002dhc.1	-	12	1917_1919	c.1694_1696delTGG	c.(1693-1698)GTGGCT>GCT	p.V565del		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	565					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TTTGGCTTAGCCACCACCACCAC	0.478													-	20370702	-	-	20370700	7	5	113	1	0	1	0	1	0	0	0	0	11674	739	26	0	62	0	PDILT	16	20370700	In_Frame_Del	DEL	CCA	TCGA-12-0618-01A-01D-1492-08		20370700	69984053	53	7719											
NUP88	4927	broad.mit.edu	37	chr17	5322843	5322843	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgaaggcaacgacgaagaaGctggtttctcagcttcggtt	12	9	1	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr17:5322843G>A	uc002gbo.1	-	1	154	c.128C>T	c.(127-129)GCT>GTT	p.A43V	NUP88_uc010vsx.1_Missense_Mutation_p.A43V|NUP88_uc010cle.1_Missense_Mutation_p.A43V|NUP88_uc010vsy.1_Missense_Mutation_p.A43V|RPAIN_uc010vsz.1_5'Flank|RPAIN_uc002gbp.1_5'Flank|RPAIN_uc010vta.1_5'Flank|RPAIN_uc002gbq.2_5'Flank|RPAIN_uc010vtb.1_5'Flank|RPAIN_uc002gbs.2_5'Flank|RPAIN_uc002gbt.2_5'Flank|RPAIN_uc002gbu.2_5'Flank|RPAIN_uc002gbv.2_5'Flank|RPAIN_uc002gbr.2_5'Flank|RPAIN_uc002gbw.2_5'Flank	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	43					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						CGACGAAGAAGCTGGTTTCTC	0.602													A	5322843	A	A	5322843	3	1	113	1	0	0	0	0	1	0	0	0	10771	971	34	3	2165	3	NUP88	17	5322843	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08		5322843	75872367	54	7720											
TP53	7157	broad.mit.edu	37	chr17	7577568	7577568	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcccatgcaggaactgttaCacatgtagttgtagtggatg	12	8	0	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr17:7577568C>T	uc002gim.2	-	7	907	c.713G>A	c.(712-714)TGT>TAT	p.C238Y	TP53_uc002gig.1_Missense_Mutation_p.C238Y|TP53_uc002gih.2_Missense_Mutation_p.C238Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106Y|TP53_uc010cng.1_Missense_Mutation_p.C106Y|TP53_uc002gii.1_Missense_Mutation_p.C106Y|TP53_uc010cnh.1_Missense_Mutation_p.C238Y|TP53_uc010cni.1_Missense_Mutation_p.C238Y|TP53_uc002gij.2_Missense_Mutation_p.C238Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145Y|TP53_uc002gio.2_Missense_Mutation_p.C106Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577568	T	T	7577568	3	4	113	1	0	0	0	0	1	0	0	0	16378	478	17	3	577	3	TP53	17	7577568	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	2254725	7577568	73617642	55	7721											
ZCCHC2	54877	broad.mit.edu	37	chr18	60243794	60243794	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccccccttctaatgatacGttggattctgcagactgaaa	7	12	2	3			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr18:60243794G>A	uc002lip.3	+	14	3519	c.3519G>A	c.(3517-3519)ACG>ACA	p.T1173T	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Silent_p.T643T	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	1173					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						CTAATGATACGTTGGATTCTG	0.468													A	60243794	A	A	60243794	2	1	113	1	0	0	0	0	0	0	0	1	17584	1132	40	1		1	ZCCHC2	18	60243794	Silent	SNP	G	TCGA-12-0618-01A-01D-1492-08		60243794	17833454	56	7722											
ARHGEF18	23370	broad.mit.edu	37	chr19	7531967	7531967	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctccgcagcttgtccagcGgatccagacactgtcccagc	9	17	1	1	rs150543189		TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr19:7531967G>A	uc002mgi.2	+	15	2661	c.2408G>A	c.(2407-2409)CGG>CAG	p.R803Q	ARHGEF18_uc010xjm.1_Missense_Mutation_p.R645Q|ARHGEF18_uc002mgh.2_Missense_Mutation_p.R645Q|ARHGEF18_uc002mgj.1_Missense_Mutation_p.R446Q	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	803	Potential.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				CTTGTCCAGCGGATCCAGACA	0.672													A	7531967	A	A	7531967	3	1	113	1	0	0	0	0	1	0	0	0	901	1116	39	2	2466	2	ARHGEF18	19	7531967	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08		7531967	51597016	57	7723											
ZNF492	57615	broad.mit.edu	37	chr19	22846654	22846654	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccaaagcagggcaaaaaaaaTtatttccaaaaagtgatact	6	7	0	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr19:22846654T>A	uc002nqw.3	+	4	427	c.183T>A	c.(181-183)AAT>AAA	p.N61K		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	61					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				GCAAAAAAAATTATTTCCAAA	0.318													A	22846654	A	A	22846654	3	1	113	1	0	0	0	0	1	0	0	0	17940	1490	52	5	193	5	ZNF492	19	22846654	Missense_Mutation	SNP	T	TCGA-12-0618-01A-01D-1492-08	15314687	22846654	36282329	58	7724											
MAG	4099	broad.mit.edu	37	chr19	35801013	35801013	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgccccgcgtcatctgcaccGcgaggaacctctatggcgcc	11	18	3	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr19:35801013G>A	uc002nyy.1	+	8	1617	c.1468G>A	c.(1468-1470)GCG>ACG	p.A490T	MAG_uc002nyx.1_Missense_Mutation_p.A490T|MAG_uc010eds.1_Missense_Mutation_p.A465T|MAG_uc002nyz.1_Missense_Mutation_p.A490T	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	490	Ig-like C2-type 4.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CATCTGCACCGCGAGGAACCT	0.706													A	35801013	A	A	35801013	3	1	113	1	0	0	0	0	1	0	0	0	9162	1087	38	1	1490	1	MAG	19	35801013	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	12954359	35801013	23327970	59	7725											
CYP2B6	1555	broad.mit.edu	37	chr19	41512932	41512932	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaagatgctgaacttgttcTaccagactttttcactcatc	6	10	3	4	rs140578107	by1000genomes	TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr19:41512932T>C	uc002opr.1	+	4	614	c.607T>C	c.(607-609)TAC>CAC	p.Y203H	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	203					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	GAACTTGTTCTACCAGACTTT	0.512													C	41512932	C	C	41512932	3	2	113	1	0	0	0	0	1	0	0	0	4164	1522	53	4	621	4	CYP2B6	19	41512932	Missense_Mutation	SNP	T	TCGA-12-0618-01A-01D-1492-08	5711919	41512932	17616051	60	7726											
TULP2	7288	broad.mit.edu	37	chr19	49398651	49398651	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccgcggtgtcgggaggccGcgctcgcccctgccgtctcc	15	18	1	0			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr19:49398651G>A	uc002pkz.2	-	5	472	c.321C>T	c.(319-321)CGC>CGT	p.R107R		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	107					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		TCGGGAGGCCGCGCTCGCCCC	0.488													A	49398651	A	A	49398651	2	1	113	1	0	0	0	0	0	0	0	1	16771	1074	38	1		1	TULP2	19	49398651	Silent	SNP	G	TCGA-12-0618-01A-01D-1492-08	7885719	49398651	9730332	61	7727											
RPN2	6185	broad.mit.edu	37	chr20	35865068	35865068	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccatcctgggcagtgtgacGtttctggctggcaatcggat	14	10	1	1			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr20:35865068G>A	uc002xgp.2	+	16	2143	c.1839G>A	c.(1837-1839)ACG>ACA	p.T613T	RPN2_uc002xgq.2_Silent_p.T581T	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	613	Helical; (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GCAGTGTGACGTTTCTGGCTG	0.532													A	35865068	A	A	35865068	2	1	113	1	0	0	0	0	0	0	0	1	13608	1132	40	1		1	RPN2	20	35865068	Silent	SNP	G	TCGA-12-0618-01A-01D-1492-08		35865068	27160452	62	7728											
TSHZ2	128553	broad.mit.edu	37	chr20	51870661	51870661	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccgatgccgacagtgcagcGcggcctatgacaccctagtc	11	15	0	1	rs141167641	by1000genomes	TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr20:51870661G>A	uc002xwo.2	+	2	1620	c.664G>A	c.(664-666)GCG>ACG	p.A222T		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	222	C2H2-type 1.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A222T(1)		ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			ACAGTGCAGCGCGGCCTATGA	0.562													A	51870661	A	A	51870661	3	1	113	1	0	0	0	0	1	0	0	0	16621	1087	38	1	670	1	TSHZ2	20	51870661	Missense_Mutation	SNP	G	TCGA-12-0618-01A-01D-1492-08	16005593	51870661	11154859	63	7729											
INPP5J	27124	broad.mit.edu	37	chr22	31524557	31524557	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacggaagagccaccgactcCaggtgacgcagcacagctac	12	14	0	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr22:31524557C>T	uc003aju.3	+	9	2202	c.2110C>T	c.(2110-2112)CAG>TAG	p.Q704*	INPP5J_uc003ajv.3_Nonsense_Mutation_p.Q337*|INPP5J_uc003ajs.3_Nonsense_Mutation_p.Q337*|INPP5J_uc011alk.1_Nonsense_Mutation_p.Q637*|INPP5J_uc010gwg.2_Nonsense_Mutation_p.Q269*|INPP5J_uc003ajw.2_Nonsense_Mutation_p.Q140*|INPP5J_uc003ajt.3_Nonsense_Mutation_p.Q336*|INPP5J_uc003ajx.2_Nonsense_Mutation_p.Q69*|INPP5J_uc003ajy.2_Nonsense_Mutation_p.Q69*|INPP5J_uc003ajz.2_Nonsense_Mutation_p.Q144*	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	704	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						CCACCGACTCCAGGTGACGCA	0.602													T	31524557	T	T	31524557	4	4	113	1	0	0	0	0	0	1	0	0	7759	595	21	3	1040	3	INPP5J	22	31524557	Nonsense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08		31524557	19780009	64	7730											
PHF5A	84844	broad.mit.edu	37	chr22	41863525	41863525	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcctccacagatcacacagCgcccctggtaagatccatag	8	15	1	2			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr22:41863525C>T	uc003bab.2	-	3	221	c.170G>A	c.(169-171)CGC>CAC	p.R57H	ACO2_uc003bac.2_5'Flank|ACO2_uc003bad.2_5'Flank	NM_032758	NP_116147	Q7RTV0	PHF5A_HUMAN	PHD-finger 5A	57					nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent	nuclear speck|U12-type spliceosomal complex|U2 snRNP	DNA binding|sequence-specific DNA binding transcription factor activity				0						GATCACACAGCGCCCCTGGTA	0.502													T	41863525	T	T	41863525	3	4	113	1	0	0	0	0	1	0	0	0	11837	768	27	1	170	1	PHF5A	22	41863525	Missense_Mutation	SNP	C	TCGA-12-0618-01A-01D-1492-08	10338968	41863525	9441041	65	7731											
NAGA	4668	broad.mit.edu	37	chr22	42456400	42456400	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggccactgatgatgtcaccTgagtagacgtcctgggcctg	13	11	1	4			TCGA-12-0618-01A-01D-1492-08	TCGA-12-0618-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	390fc5e9-787e-4a3f-86c8-e3e0e7e43824	f4a5c29a-142f-416b-904b-bd0eb9c9b514	g.chr22:42456400T>G	uc003bbx.2	-	10	1256	c.1119A>C	c.(1117-1119)TCA>TCC	p.S373S	NAGA_uc003bby.2_Silent_p.S373S|NAGA_uc003bbw.3_Silent_p.S373S	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	373					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						TGATGTCACCTGAGTAGACGT	0.557													G	42456400	G	G	42456400	2	3	113	1	0	0	0	0	0	0	0	1	10141	1567	55	5		5	NAGA	22	42456400	Silent	SNP	T	TCGA-12-0618-01A-01D-1492-08	592875	42456400	8848166	66	7732											
PTPRU	10076	broad.mit.edu	37	chr1	29602053	29602053	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgggctacaacgtgacgcGttgccacacctatactgtgt	10	12	0	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr1:29602053G>A	uc001bru.2	+	8	1348	c.1238G>A	c.(1237-1239)CGT>CAT	p.R413H	PTPRU_uc001brv.2_Missense_Mutation_p.R413H|PTPRU_uc001brw.2_Missense_Mutation_p.R413H|PTPRU_uc009vtq.2_Missense_Mutation_p.R413H|PTPRU_uc009vtr.2_Missense_Mutation_p.R413H	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	413	Fibronectin type-III 2.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		AACGTGACGCGTTGCCACACC	0.592													A	29602053	A	A	29602053	3	1	114	1	0	0	0	0	1	0	0	0	12813	1145	40	1	1268	1	PTPRU	1	29602053	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08		29602053	219648568	1	7733											
CYP4B1	1580	broad.mit.edu	37	chr1	47282838	47282838	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtcacctttgtggatggcCggtctctacctgcaggtggg	14	11	2	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr1:47282838C>T	uc001cqm.3	+	9	1273	c.1189C>T	c.(1189-1191)CGG>TGG	p.R397W	CYP4B1_uc001cqn.3_Missense_Mutation_p.R398W|CYP4B1_uc009vym.2_Missense_Mutation_p.R383W|CYP4B1_uc010omk.1_Missense_Mutation_p.R234W	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	397					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TGTGGATGGCCGGTCTCTACC	0.567													T	47282838	T	T	47282838	3	4	114	1	0	0	0	0	1	0	0	0	4185	643	23	2	1226	2	CYP4B1	1	47282838	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	17680785	47282838	201967783	2	7734											
LYST	1130	broad.mit.edu	37	chr1	235860518	235860518	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaccacaggtactggagcacTgggggaacccacgtattccc	12	13	0	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr1:235860518T>C	uc001hxj.2	-	46	10604	c.10429A>G	c.(10429-10431)AGT>GGT	p.S3477G	LYST_uc001hxi.2_Missense_Mutation_p.S701G	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3477					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ACTGGAGCACTGGGGGAACCC	0.473									Chediak-Higashi_syndrome				C	235860518	C	C	235860518	3	2	114	1	0	0	0	0	1	0	0	0	9128	1580	55	4	1008	4	LYST	1	235860518	Missense_Mutation	SNP	T	TCGA-12-0619-01A-01D-1492-08	188577680	235860518	13390103	3	7735											
RYR2	6262	broad.mit.edu	37	chr1	237890471	237890471	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggctgttgtagcctgcttcCggatggcccccttatataat	11	11	0	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr1:237890471C>T	uc001hyl.1	+	76	10930	c.10810C>T	c.(10810-10812)CGG>TGG	p.R3604W	RYR2_uc010pya.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3604					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCCTGCTTCCGGATGGCCCC	0.403													T	237890471	T	T	237890471	3	4	114	1	0	0	0	0	1	0	0	0	13769	643	23	2	11112	2	RYR2	1	237890471	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	2029953	237890471	11360150	4	7736											
MCM6	4175	broad.mit.edu	37	chr2	136630288	136630288	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tatagaactcctcttgaatgGtggtggaaagttgctggtta	12	5	1	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr2:136630288G>C	uc002tuw.2	-	2	309	c.233C>G	c.(232-234)ACC>AGC	p.T78S		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	78					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CTCTTGAATGGTGGTGGAAAG	0.413													C	136630288	C	C	136630288	3	2	114	1	0	0	0	0	1	0	0	0	9391	1261	44	5	2296	5	MCM6	2	136630288	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08		136630288	106569085	5	7737											
SCN10A	6336	broad.mit.edu	37	chr3	38755494	38755494	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccgcagtggccgcagagcGcgaagggttcgaagggcttt	17	11	0	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr3:38755494G>A	uc003ciq.2	-	21	3759	c.3759C>T	c.(3757-3759)CGC>CGT	p.R1253R		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1253	III.|Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GCCGCAGAGCGCGAAGGGTTC	0.443													A	38755494	A	A	38755494	2	1	114	1	0	0	0	0	0	0	0	1	13912	1074	38	1		1	SCN10A	3	38755494	Silent	SNP	G	TCGA-12-0619-01A-01D-1492-08		38755494	159266936	6	7738											
SCN11A	11280	broad.mit.edu	37	chr3	38913127	38913128	+	Frame_Shift_Ins	INS	-	C	C													cccagaatacaaaatacgagINSccagaaaatgaggcagacaa							TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr3:38913127_38913128insC	uc011ays.1	-	21	3766_3767	c.3567_3568insG	c.(3565-3570)TGGCTCfs	p.W1189fs		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1189_1190	Helical; Name=S5 of repeat III; (By similarity).|III.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CAAAATACGAGCCAGAAAATGA	0.361													C	38913128	C	C	38913127	7	5	114	1	0	1	1	0	0	0	0	0	13913	971	34	0	1831	0	SCN11A	3	38913127	Frame_Shift_Ins	INS	-	TCGA-12-0619-01A-01D-1492-08	157633	38913127	159109303	7	7739											
GNB4	59345	broad.mit.edu	37	chr3	179137188	179137189	+	Frame_Shift_Ins	INS	-	G	G													gtaatgacaggtacaaacctINSggaatcgtatccccaatgca							TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr3:179137188_179137189insG	uc003fjv.3	-	4	481_482	c.201_202insC	c.(199-204)TCCAGGfs	p.S67fs	GNB4_uc003fju.3_5'Flank	NM_021629	NP_067642	Q9HAV0	GBB4_HUMAN	guanine nucleotide-binding protein, beta-4	67_68	WD 1.				cellular response to glucagon stimulus|energy reserve metabolic process	plasma membrane	signal transducer activity			skin(2)	2	all_cancers(143;2.01e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.237)			GGTACAAACCTGGAATCGTATC	0.361													G	179137189	G	G	179137188	7	5	114	1	0	1	1	0	0	0	0	0	6520	1594	55	0	848	0	GNB4	3	179137188	Frame_Shift_Ins	INS	-	TCGA-12-0619-01A-01D-1492-08	140224061	179137188	18885242	8	7740											
ETV5	2119	broad.mit.edu	37	chr3	185823619	185823619	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccacataaacttacccctggGaccataaaagggacttgctg	8	12	0	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr3:185823619G>A	uc003fpz.2	-	2	286	c.39C>T	c.(37-39)GTC>GTT	p.V13V	ETV5_uc003fpy.2_Silent_p.V55V	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	13					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			TTACCCCTGGGACCATAAAAG	0.453			T	TMPRSS2|SCL45A3	Prostate 								A	185823619	A	A	185823619	2	1	114	1	0	0	0	0	0	0	0	1	5282	1161	41	3		3	ETV5	3	185823619	Silent	SNP	G	TCGA-12-0619-01A-01D-1492-08	6686431	185823619	12198811	9	7741											
TACC3	10460	broad.mit.edu	37	chr4	1725208	1725208	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaaaaatacagaaaattgCgacttcctgttttcgccacc	6	10	0	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr4:1725208C>T	uc003gdo.2	+	2	168	c.60C>T	c.(58-60)TGC>TGT	p.C20C	TMEM129_uc003gdn.2_5'Flank|TMEM129_uc003gdm.2_5'Flank|TACC3_uc010ibz.2_Silent_p.C20C|TACC3_uc003gdp.2_Silent_p.C20C	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	20						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CAGAAAATTGCGACTTCCTGT	0.433													T	1725208	T	T	1725208	2	4	114	1	0	0	0	0	0	0	0	1	15500	776	27	1		1	TACC3	4	1725208	Silent	SNP	C	TCGA-12-0619-01A-01D-1492-08		1725208	189429068	10	7742											
TBC1D9	23158	broad.mit.edu	37	chr4	141580777	141580777	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtagtaatctgggagcatgCgctcacacaaagccacaagc	10	11	2	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr4:141580777C>T	uc010ioj.2	-	11	2158	c.1886G>A	c.(1885-1887)CGC>CAC	p.R629H		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	629	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TGGGAGCATGCGCTCACACAA	0.448													T	141580777	T	T	141580777	3	4	114	1	0	0	0	0	1	0	0	0	15624	768	27	1	1958	1	TBC1D9	4	141580777	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	139855569	141580777	49573499	11	7743											
GRIA2	2891	broad.mit.edu	37	chr4	158284178	158284178	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggttacaacgtatatggcatCgaaagtgttaaaatttaggg	11	4	0	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr4:158284178C>T	uc003ipm.3	+	15	3093	c.2634C>T	c.(2632-2634)ATC>ATT	p.I878I	GRIA2_uc011cit.1_Silent_p.I831I|GRIA2_uc003ipl.3_Silent_p.I878I|GRIA2_uc003ipk.3_Silent_p.I831I|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_3'UTR|GRIA2_uc011ciy.1_3'UTR|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	878	Cytoplasmic (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.I878I(1)		central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TATATGGCATCGAAAGTGTTA	0.378													T	158284178	T	T	158284178	2	4	114	1	0	0	0	0	0	0	0	1	6768	874	31	2		2	GRIA2	4	158284178	Silent	SNP	C	TCGA-12-0619-01A-01D-1492-08	16703401	158284178	32870098	12	7744											
DNAH5	1767	broad.mit.edu	37	chr5	13753418	13753418	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gatcaattaacaaagggtaaCgagatgccttcgtgacaata	9	7	1	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr5:13753418C>G	uc003jfd.2	-	63	10838	c.10796G>C	c.(10795-10797)CGT>CCT	p.R3599P	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3599	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAAAGGGTAACGAGATGCCTT	0.368									Kartagener_syndrome				G	13753418	G	G	13753418	3	3	114	1	0	0	0	0	1	0	0	0	4604	536	19	5	3146	5	DNAH5	5	13753418	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08		13753418	167161842	13	7745											
RNASEN	29102	broad.mit.edu	37	chr5	31468080	31468080	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ataactcaactgtgcagggcGtatcccaaagtggacgataa	10	9	1	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr5:31468080G>A	uc003jhg.2	-	17	2691	c.2332C>T	c.(2332-2334)CGC>TGC	p.R778C	RNASEN_uc003jhh.2_Missense_Mutation_p.R741C|RNASEN_uc003jhi.2_Missense_Mutation_p.R741C	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	778	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						TGTGCAGGGCGTATCCCAAAG	0.438													A	31468080	A	A	31468080	3	1	114	1	0	0	0	0	1	0	0	0	13417	1145	40	1	1868	1	RNASEN	5	31468080	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	17714662	31468080	149447180	14	7746											
MAP3K1	4214	broad.mit.edu	37	chr5	56160697	56160697	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttactgcagcagatagggcCtaactctttcctgattggag	10	10	1	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr5:56160697C>T	uc003jqw.3	+	4	1472	c.971C>T	c.(970-972)CCT>CTT	p.P324L		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	324					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		CAGATAGGGCCTAACTCTTTC	0.468													T	56160697	T	T	56160697	3	4	114	1	0	0	0	0	1	0	0	0	9243	681	24	3	985	3	MAP3K1	5	56160697	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	24692617	56160697	124754563	15	7747											
GRAMD3	65983	broad.mit.edu	37	chr5	125821443	125821443	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aatgtccgatgcttcaccatAttcttatattctatgcaatt	4	9	3	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr5:125821443A>T	uc003ktu.2	+	11	1466	c.1036A>T	c.(1036-1038)ATT>TTT	p.I346F	GRAMD3_uc011cwt.1_Missense_Mutation_p.I361F|GRAMD3_uc011cwv.1_Missense_Mutation_p.I354F|GRAMD3_uc011cww.1_Missense_Mutation_p.I242F|GRAMD3_uc011cwx.1_RNA|GRAMD3_uc011cwy.1_Missense_Mutation_p.I237F|GRAMD3_uc011cwz.1_Missense_Mutation_p.I330F	NM_023927	NP_076416	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3 isoform 2	346										central_nervous_system(1)	1		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		GCTTCACCATATTCTTATATT	0.348													T	125821443	T	T	125821443	3	4	114	1	0	0	0	0	1	0	0	0	6751	449	16	5	1292	5	GRAMD3	5	125821443	Missense_Mutation	SNP	A	TCGA-12-0619-01A-01D-1492-08	69660746	125821443	55093817	16	7748											
PCDHA10	56139	broad.mit.edu	37	chr5	140236992	140236992	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaacgacaacgcgcctgcGttcgcgcagtccgagtacac	12	14	0	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr5:140236992G>A	uc003lhx.2	+	1	1359	c.1359G>A	c.(1357-1359)GCG>GCA	p.A453A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.A453A|PCDHA10_uc011dad.1_Silent_p.A453A	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	453	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding	p.A453A(2)		ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCGCCTGCGTTCGCGCAGT	0.677													A	140236992	A	A	140236992	2	1	114	1	0	0	0	0	0	0	0	1	11520	1132	40	1		1	PCDHA10	5	140236992	Silent	SNP	G	TCGA-12-0619-01A-01D-1492-08	14415549	140236992	40678268	17	7749											
PCDHB2	56133	broad.mit.edu	37	chr5	140475875	140475875	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgccccaggacccgcacctgCccctcgcctccctggtctcc	8	24	1	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr5:140475875C>A	uc003lil.2	+	1	1639	c.1501C>A	c.(1501-1503)CCC>ACC	p.P501T	PCDHB2_uc003lim.1_Missense_Mutation_p.P162T	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	501	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCGCACCTGCCCCTCGCCTC	0.692													A	140475875	A	A	140475875	3	1	114	1	0	0	0	0	1	0	0	0	11542	739	26	5	1503	5	PCDHB2	5	140475875	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	238883	140475875	40439385	18	7750											
GPR116	221395	broad.mit.edu	37	chr6	46856078	46856078	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtctcttactcacctgttgTcacatttatgctcaaaatgt	6	10	4	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr6:46856078T>C	uc003oyo.3	-	4	611	c.322A>G	c.(322-324)ACA>GCA	p.T108A	GPR116_uc003oyp.3_Missense_Mutation_p.T108A|GPR116_uc003oyq.3_Missense_Mutation_p.T108A|GPR116_uc003oyr.2_Missense_Mutation_p.T108A	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	108	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			TCACCTGTTGTCACATTTATG	0.403													C	46856078	C	C	46856078	3	2	114	1	0	0	0	0	1	0	0	0	6633	1667	58	4	3790	4	GPR116	6	46856078	Missense_Mutation	SNP	T	TCGA-12-0619-01A-01D-1492-08		46856078	124258989	19	7751											
HTR1E	3354	broad.mit.edu	37	chr6	87725312	87725312	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catctacattgtcatggatcGctggaagcttgggtacttcc	10	10	2	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr6:87725312G>A	uc003pli.2	+	2	963	c.260G>A	c.(259-261)CGC>CAC	p.R87H		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	87	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	GTCATGGATCGCTGGAAGCTT	0.572													A	87725312	A	A	87725312	3	1	114	1	0	0	0	0	1	0	0	0	7439	1087	38	1	262	1	HTR1E	6	87725312	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	40869234	87725312	83389755	20	7752											
SDK1	221935	broad.mit.edu	37	chr7	4169639	4169639	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcaggcctgcgcaagttcGtgctctacgagctccaggtg	14	12	1	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr7:4169639G>A	uc003smx.2	+	27	4178	c.4039G>A	c.(4039-4041)GTG>ATG	p.V1347M	SDK1_uc010kso.2_Missense_Mutation_p.V623M|SDK1_uc003smy.2_Translation_Start_Site	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1347	Fibronectin type-III 7.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GCGCAAGTTCGTGCTCTACGA	0.657													A	4169639	A	A	4169639	3	1	114	1	0	0	0	0	1	0	0	0	13968	1145	40	1	4145	1	SDK1	7	4169639	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08		4169639	154969024	21	7753											
SKAP2	8935	broad.mit.edu	37	chr7	26778465	26778465	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttactgagagcacaccaccGtttctgccattcaaatccca	5	14	2	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr7:26778465G>A	uc003syc.2	-	6	711	c.418C>T	c.(418-420)CGG>TGG	p.R140W	SKAP2_uc011jzi.1_Translation_Start_Site|SKAP2_uc011jzj.1_Missense_Mutation_p.R125W	NM_003930	NP_003921	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	140	PH.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			pancreas(1)	1						GCACACCACCGTTTCTGCCAT	0.274													A	26778465	A	A	26778465	3	1	114	1	0	0	0	0	1	0	0	0	14356	1144	40	1	689	1	SKAP2	7	26778465	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	22608826	26778465	132360198	22	7754											
ZPBP	11055	broad.mit.edu	37	chr7	50097662	50097662	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attcgaggaaacatgtataaAttccactcatactctcctca	4	11	3	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr7:50097662A>G	uc003tou.2	-	4	480	c.410T>C	c.(409-411)ATT>ACT	p.I137T	ZPBP_uc011kci.1_Missense_Mutation_p.I63T|ZPBP_uc010kyw.2_Missense_Mutation_p.I136T	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	137					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					ACATGTATAAATTCCACTCAT	0.333													G	50097662	G	G	50097662	3	3	114	1	0	0	0	0	1	0	0	0	18216	101	4	4	665	4	ZPBP	7	50097662	Missense_Mutation	SNP	A	TCGA-12-0619-01A-01D-1492-08	23319197	50097662	109041001	23	7755											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	114	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	5135381	55233043	103905620	24	7756											
PTPN12	5782	broad.mit.edu	37	chr7	77256938	77256938	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctactaggaaagtattgccaAtgtccattgctagacataat	7	8	0	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr7:77256938A>G	uc003ugh.2	+	13	2033	c.1942A>G	c.(1942-1944)ATG>GTG	p.M648V	PTPN12_uc011kgp.1_Missense_Mutation_p.M529V|PTPN12_uc011kgq.1_Missense_Mutation_p.M518V|PTPN12_uc010lds.2_Missense_Mutation_p.M380V	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	648						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						AGTATTGCCAATGTCCATTGC	0.313													G	77256938	G	G	77256938	3	3	114	1	0	0	0	0	1	0	0	0	12781	101	4	4	1992	4	PTPN12	7	77256938	Missense_Mutation	SNP	A	TCGA-12-0619-01A-01D-1492-08	22023895	77256938	81881725	25	7757											
PAX4	5078	broad.mit.edu	37	chr7	127254980	127254980	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccttcagcacaaagctggCgttggatttcccaggcaaag	11	12	1	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr7:127254980C>T	uc010lld.1	-	2	496	c.290G>A	c.(289-291)CGC>CAC	p.R97H	PAX4_uc003vmf.2_Missense_Mutation_p.R95H|PAX4_uc003vmg.1_Missense_Mutation_p.R97H|PAX4_uc003vmh.2_Missense_Mutation_p.R95H	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	105	Paired.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACAAAGCTGGCGTTGGATTTC	0.592													T	127254980	T	T	127254980	3	4	114	1	0	0	0	0	1	0	0	0	11481	768	27	1	773	1	PAX4	7	127254980	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	49998042	127254980	31883683	26	7758											
PLXNA4	91584	broad.mit.edu	37	chr7	131872333	131872333	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtccctccggacatgggccCccggctgggcttcagatctg	14	15	2	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr7:131872333C>T	uc003vra.3	-	15	3119	c.2890G>A	c.(2890-2892)GGG>AGG	p.G964R		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	964	IPT/TIG 2.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GACATGGGCCCCCGGCTGGGC	0.587													T	131872333	T	T	131872333	3	4	114	1	0	0	0	0	1	0	0	0	12122	623	22	3	2866	3	PLXNA4	7	131872333	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	4617353	131872333	27266330	27	7759											
DENND2A	27147	broad.mit.edu	37	chr7	140301257	140301257	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acagtcttctgttcacagagGaaggtgggggagaggagggc	18	6	3	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr7:140301257G>A	uc010lnj.2	-	1	1086	c.941C>T	c.(940-942)TCC>TTC	p.S314F	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.S314F|DENND2A_uc003vvw.2_Missense_Mutation_p.S314F|DENND2A_uc003vvx.2_Missense_Mutation_p.S314F	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	314										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GTTCACagaggaaggtggggg	0.393													A	140301257	A	A	140301257	3	1	114	1	0	0	0	0	1	0	0	0	4429	1174	41	3	2160	3	DENND2A	7	140301257	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	8428924	140301257	18837406	28	7760											
ODF2	4957	broad.mit.edu	37	chr9	131233667	131233667	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagctggaggaggtggcccaCgaactggctgagactgagca	17	9	0	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr9:131233667C>T	uc011mbd.1	+	6	812	c.501C>T	c.(499-501)CAC>CAT	p.H167H	ODF2_uc011maz.1_Silent_p.H167H|ODF2_uc011mba.1_Intron|ODF2_uc010myb.2_Silent_p.H143H|ODF2_uc011mbb.1_Silent_p.H101H|ODF2_uc011mbc.1_Silent_p.H86H|ODF2_uc004bva.2_Silent_p.H120H|ODF2_uc004bvb.2_Silent_p.H143H|ODF2_uc011mbe.1_Silent_p.H162H|ODF2_uc004bvc.2_Silent_p.H143H|ODF2_uc010myc.2_Silent_p.H110H|ODF2_uc011mbf.1_Silent_p.H148H|ODF2_uc004bvd.3_Silent_p.H167H|ODF2_uc004bve.2_Silent_p.H148H	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	167	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						AGGTGGCCCACGAACTGGCTG	0.577													T	131233667	T	T	131233667	2	4	114	1	0	0	0	0	0	0	0	1	10827	535	19	1		1	ODF2	9	131233667	Silent	SNP	C	TCGA-12-0619-01A-01D-1492-08		131233667	9979764	29	7761											
PRDM12	59335	broad.mit.edu	37	chr9	133540113	133540113	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcgccgggactggcgctgGccgaggttatcacctccgac	15	14	1	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr9:133540113G>A	uc004bzt.1	+	1	133	c.73G>A	c.(73-75)GCC>ACC	p.A25T		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	25					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		ACTGGCGCTGGCCGAGGTTAT	0.577													A	133540113	A	A	133540113	3	1	114	1	0	0	0	0	1	0	0	0	12453	1203	42	3	75	3	PRDM12	9	133540113	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	2306446	133540113	7673318	30	7762			1	27		2	2	12	N	G_C	2.416246e-05
PRDM12	59335	broad.mit.edu	37	chr9	133540124	133540124	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctggcgctggccgaggttatCacctccgacatcctgcacag	11	15	1	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr9:133540124C>T	uc004bzt.1	+	1	144	c.84C>T	c.(82-84)ATC>ATT	p.I28I		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		CCGAGGTTATCACCTCCGACA	0.612													T	133540124	T	T	133540124	2	4	114	1	0	0	0	0	0	0	0	1	12453	816	29	3		3	PRDM12	9	133540124	Silent	SNP	C	TCGA-12-0619-01A-01D-1492-08	11	133540124	7673307	31	7763			1	27		2	2	12	N	G_C	2.416246e-05
KIAA0649	9858	broad.mit.edu	37	chr9	138379880	138379880	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agacctgaggtatcgacgaaGggtcaacagggatgaccagg	15	8	1	3			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr9:138379880G>C	uc004cfr.1	+	4	4073	c.3524G>C	c.(3523-3525)AGG>ACG	p.R1175T		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	1175						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		TATCGACGAAGGGTCAACAGG	0.607													C	138379880	C	C	138379880	3	2	114	1	0	0	0	0	1	0	0	0	8187	1000	35	5	3526	5	KIAA0649	9	138379880	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	4839756	138379880	2833551	32	7764											
STAMBPL1	57559	broad.mit.edu	37	chr10	90674395	90674395	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgagaggaatagaaacctgtGgaatactctgtggaaaactg	12	5	1	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr10:90674395G>T	uc001kfk.2	+	7	1306	c.883G>T	c.(883-885)GGA>TGA	p.G295*	STAMBPL1_uc010qmx.1_Nonsense_Mutation_p.G295*|STAMBPL1_uc009xto.2_RNA|STAMBPL1_uc001kfl.2_Nonsense_Mutation_p.G295*|STAMBPL1_uc001kfn.2_Nonsense_Mutation_p.G129*	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	295	MPN.						metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		AGAAACCTGTGGAATACTCTG	0.333													T	90674395	T	T	90674395	4	4	114	1	0	0	0	0	0	1	0	0	15250	1349	47	5	905	5	STAMBPL1	10	90674395	Nonsense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08		90674395	44860352	33	7765											
MUC5B	727897	broad.mit.edu	37	chr11	1266158	1266158	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	accctcctctagcacacagaCcagtggtactcccccatcac	5	19	2	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr11:1266158C>G	uc009ycr.1	+	48	10088	c.9962C>G	c.(9961-9963)ACC>AGC	p.T3321S	MUC5B_uc001ltb.2_Missense_Mutation_p.T2686S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2734	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGCACACAGACCAGTGGTACT	0.333													G	1266158	G	G	1266158	3	3	114	1	0	0	0	0	1	0	0	0	9979	507	18	5	8179	5	MUC5B	11	1266158	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08		1266158	133740358	34	7766											
IGSF22	283284	broad.mit.edu	37	chr11	18731138	18731138	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaaggatgtagccagaggGtgggtctccctctgcaggct	14	11	3	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr11:18731138G>A	uc009yht.2	-	18	2984	c.2794C>T	c.(2794-2796)CCC>TCC	p.P932S	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	831	Fibronectin type-III 2.									ovary(4)|large_intestine(2)|kidney(1)	7						TAGCCAGAGGGTGGGTCTCCC	0.582													A	18731138	A	A	18731138	3	1	114	1	0	0	0	0	1	0	0	0	7600	1261	44	3	1210	3	IGSF22	11	18731138	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	17464980	18731138	116275378	35	7767											
SLC2A14	144195	broad.mit.edu	37	chr12	7980153	7980153	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaatgatgatgggctgtcGgtagctggacactctaaaga	14	6	1	3			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr12:7980153G>A	uc001qtk.2	-	12	1664	c.871C>T	c.(871-873)CGA>TGA	p.R291*	SLC2A14_uc001qtl.2_Nonsense_Mutation_p.R268*|SLC2A14_uc001qtm.2_Nonsense_Mutation_p.R268*|SLC2A14_uc010sgg.1_Nonsense_Mutation_p.R182*|SLC2A14_uc001qtn.2_Nonsense_Mutation_p.R291*|SLC2A14_uc001qto.2_Intron|SLC2A14_uc010sgh.1_Nonsense_Mutation_p.R306*	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	291	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		ATGGGCTGTCGGTAGCTGGAC	0.478													A	7980153	A	A	7980153	4	1	114	1	0	0	0	0	0	1	0	0	14543	1124	39	2	711	2	SLC2A14	12	7980153	Nonsense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08		7980153	125871742	36	7768											
SLC2A3	6515	broad.mit.edu	37	chr12	8082342	8082342	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaatgatgatgggctgtcGgtagctggacactctaaaga	14	6	1	3			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr12:8082342G>A	uc001qtr.2	-	6	1061	c.799C>T	c.(799-801)CGA>TGA	p.R267*	SLC2A3_uc001qts.2_3'UTR	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	267	Cytoplasmic (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		ATGGGCTGTCGGTAGCTGGAC	0.473													A	8082342	A	A	8082342	4	1	114	1	0	0	0	0	0	1	0	0	14545	1124	39	2	711	2	SLC2A3	12	8082342	Nonsense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	102189	8082342	125769553	37	7769											
IGF1	3479	broad.mit.edu	37	chr12	102813354	102813354	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagctgacttggcaggcttgAggggtgcgcaatacatctcc	14	10	1	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr12:102813354A>G	uc001tjp.3	-	3	554	c.335T>C	c.(334-336)CTC>CCC	p.L112P	IGF1_uc001tjn.2_Missense_Mutation_p.L96P|IGF1_uc001tjm.2_Missense_Mutation_p.L112P|IGF1_uc001tjo.2_Missense_Mutation_p.L112P	NM_001111285	NP_001104755	P05019	IGF1_HUMAN	insulin-like growth factor 1 isoform 3	112	D.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2						GGCAGGCTTGAGGGGTGCGCA	0.617													G	102813354	G	G	102813354	3	3	114	1	0	0	0	0	1	0	0	0	7570	304	11	4	324	4	IGF1	12	102813354	Missense_Mutation	SNP	A	TCGA-12-0619-01A-01D-1492-08	94731012	102813354	31038541	38	7770											
RASAL1	8437	broad.mit.edu	37	chr12	113565893	113565893	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acagtgtcctcatccagcacGtagaaggccagctggtggaa	12	11	1	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr12:113565893G>C	uc001tum.1	-	4	506	c.213C>G	c.(211-213)TAC>TAG	p.Y71*	RASAL1_uc010syp.1_Nonsense_Mutation_p.Y71*|RASAL1_uc001tul.2_Nonsense_Mutation_p.Y71*|RASAL1_uc001tun.1_Nonsense_Mutation_p.Y71*|RASAL1_uc010syq.1_Nonsense_Mutation_p.Y71*|RASAL1_uc001tuo.3_Nonsense_Mutation_p.Y71*|RASAL1_uc010syr.1_Nonsense_Mutation_p.Y71*	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	71	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						CATCCAGCACGTAGAAGGCCA	0.607													C	113565893	C	C	113565893	4	2	114	1	0	0	0	0	0	1	0	0	13063	1140	40	5	2277	5	RASAL1	12	113565893	Nonsense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	10752539	113565893	20286002	39	7771											
OR10G2	26534	broad.mit.edu	37	chr14	22102746	22102746	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtaaaatccaaaataagccGaggaacggtgactgaggaga	12	6	0	3	rs141025992	byFrequency	TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr14:22102746G>A	uc010tmc.1	-	1	253	c.253C>T	c.(253-255)CGG>TGG	p.R85W		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		AAAATAAGCCGAGGAACGGTG	0.527													A	22102746	A	A	22102746	3	1	114	1	0	0	0	0	1	0	0	0	10899	1057	37	2	682	2	OR10G2	14	22102746	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08		22102746	85246794	40	7772											
EAPP	55837	broad.mit.edu	37	chr14	35005432	35005432	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acattctctgatgagttttcGtttttggtcaggagttccat	9	7	2	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr14:35005432G>A	uc001wsd.1	-	2	233	c.124C>T	c.(124-126)CGA>TGA	p.R42*		NM_018453	NP_060923	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	42					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		ATGAGTTTTCGTTTTTGGTCA	0.318													A	35005432	A	A	35005432	4	1	114	1	0	0	0	0	0	1	0	0	4877	1153	40	1	753	1	EAPP	14	35005432	Nonsense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	12902686	35005432	72344108	41	7773											
C14orf49	161176	broad.mit.edu	37	chr14	95899695	95899695	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cccccttgctggcccgagacGaaggaggttctcaaagagat	12	12	1	2	rs141951711		TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr14:95899695G>A	uc001yei.3	-	15	2605	c.2590C>T	c.(2590-2592)CGT>TGT	p.R864C	C14orf49_uc010avi.2_Missense_Mutation_p.R859C	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	864	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		GGCCCGAGACGAAGGAGGTTC	0.597													A	95899695	A	A	95899695	3	1	114	1	0	0	0	0	1	0	0	0	1776	1058	37	2	349	2	C14orf49	14	95899695	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	60894263	95899695	11449845	42	7774											
ARIH1	25820	broad.mit.edu	37	chr15	72767077	72767077	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggaggaggacgaagacgacGacgagccggacgatgatacc	16	9	0	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr15:72767077G>A	uc002aut.3	+	1	411	c.97G>A	c.(97-99)GAC>AAC	p.D33N		NM_005744	NP_005735	Q9Y4X5	ARI1_HUMAN	ariadne ubiquitin-conjugating enzyme E2 binding	33	Asp/Glu-rich (acidic).				ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding				0						cgaagacgacgacgaGCCGGA	0.393													A	72767077	A	A	72767077	3	1	114	1	0	0	0	0	1	0	0	0	923	1058	37	2	99	2	ARIH1	15	72767077	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08		72767077	29764315	43	7775											
ACSM2A	123876	broad.mit.edu	37	chr16	20492162	20492162	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtaccggattggaccctcGgaggtagagaatgcactgat	14	8	0	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr16:20492162G>A	uc010bwe.2	+	13	1667	c.1428G>A	c.(1426-1428)TCG>TCA	p.S476S	ACSM2A_uc010vax.1_Silent_p.S397S|ACSM2A_uc002dhf.3_Silent_p.S476S|ACSM2A_uc002dhg.3_Silent_p.S476S|ACSM2A_uc010vay.1_Silent_p.S397S|ACSM2A_uc002dhh.3_Silent_p.S106S	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	476					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						TTGGACCCTCGGAGGTAGAGA	0.567													A	20492162	A	A	20492162	2	1	114	1	0	0	0	0	0	0	0	1	183	1103	39	2		2	ACSM2A	16	20492162	Silent	SNP	G	TCGA-12-0619-01A-01D-1492-08		20492162	69862591	44	7776											
HS3ST4	9951	broad.mit.edu	37	chr16	26147419	26147419	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagacagcagtgccccgagGtgcttaggcaagagcaaagg	15	9	0	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr16:26147419G>A	uc002dof.2	+	2	1613	c.1221G>A	c.(1219-1221)AGG>AGA	p.R407R		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	407	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		GTGCCCCGAGGTGCTTAGGCA	0.473													A	26147419	A	A	26147419	2	1	114	1	0	0	0	0	0	0	0	1	7367	1252	44	3		3	HS3ST4	16	26147419	Silent	SNP	G	TCGA-12-0619-01A-01D-1492-08	5655257	26147419	64207334	45	7777											
SEZ6L2	26470	broad.mit.edu	37	chr16	29897033	29897033	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtccgaatcatagatcaCgggggatagggggctgcccc	14	11	2	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr16:29897033C>T	uc002duq.3	-	8	1486	c.1246G>A	c.(1246-1248)GTG>ATG	p.V416M	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.V346M|SEZ6L2_uc002dur.3_Missense_Mutation_p.V346M|SEZ6L2_uc002dus.3_Missense_Mutation_p.V302M|SEZ6L2_uc010vec.1_Missense_Mutation_p.V416M|SEZ6L2_uc010ved.1_Missense_Mutation_p.V372M	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	416	CUB 2.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TCATAGATCACGGGGGATAGG	0.612													T	29897033	T	T	29897033	3	4	114	1	0	0	0	0	1	0	0	0	14144	536	19	1	1569	1	SEZ6L2	16	29897033	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	3749614	29897033	60457720	46	7778											
LONP2	83752	broad.mit.edu	37	chr16	48303999	48303999	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	catggaaaaattgaagaaaaGagtactggaatacttggctg	11	4	0	3			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr16:48303999G>A	uc002efi.1	+	7	1144	c.1055G>A	c.(1054-1056)AGA>AAA	p.R352K	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.R308K	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	352					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						TTGAAGAAAAGAGTACTGGAA	0.443													A	48303999	A	A	48303999	3	1	114	1	0	0	0	0	1	0	0	0	8893	942	33	3	1081	3	LONP2	16	48303999	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	18406966	48303999	42050754	47	7779											
PMFBP1	83449	broad.mit.edu	37	chr16	72184650	72184650	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatcttgtccccggccaaggCgagttgctcctgcgccaaat	11	14	1	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr16:72184650C>T	uc002fcc.3	-	5	665	c.493G>A	c.(493-495)GCC>ACC	p.A165T	PMFBP1_uc002fcd.2_Missense_Mutation_p.A165T|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.A20T	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	165	Potential.									ovary(2)	2		Ovarian(137;0.179)				CCGGCCAAGGCGAGTTGCTCC	0.493													T	72184650	T	T	72184650	3	4	114	1	0	0	0	0	1	0	0	0	12134	768	27	1	2658	1	PMFBP1	16	72184650	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	23880651	72184650	18170103	48	7780											
TP53	7157	broad.mit.edu	37	chr17	7578440	7578440	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgtcatgtgctgtgactgctTgtagatggccatggcgcgga	15	9	1	2			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr17:7578440T>C	uc002gim.2	-	5	684	c.490A>G	c.(490-492)AAG>GAG	p.K164E	TP53_uc002gig.1_Missense_Mutation_p.K164E|TP53_uc002gih.2_Missense_Mutation_p.K164E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.K32E|TP53_uc010cng.1_Missense_Mutation_p.K32E|TP53_uc002gii.1_Missense_Mutation_p.K32E|TP53_uc010cnh.1_Missense_Mutation_p.K164E|TP53_uc010cni.1_Missense_Mutation_p.K164E|TP53_uc002gij.2_Missense_Mutation_p.K164E|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.K71E|TP53_uc002gio.2_Missense_Mutation_p.K32E|TP53_uc010vug.1_Missense_Mutation_p.K125E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	164	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> E (in sporadic cancers; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).|K -> Q (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> T (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K164E(12)|p.K164*(9)|p.0?(7)|p.K164N(6)|p.K164M(4)|p.K164K(2)|p.K164fs*5(2)|p.K164Q(2)|p.K164fs*6(2)|p.K164fs*3(2)|p.K164T(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.Y163fs*1(1)|p.Y163_Q165delYKQ(1)|p.P151_V173del23(1)|p.S149fs*72(1)|p.K164_Q165insXXX(1)|p.K164fs*17(1)|p.K164R(1)|p.Y163fs*14(1)|p.A159_Q167delAMAIYKQSQ(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGTGACTGCTTGTAGATGGCC	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578440	C	C	7578440	3	2	114	1	0	0	0	0	1	0	0	0	16378	1821	63	4	808	4	TP53	17	7578440	Missense_Mutation	SNP	T	TCGA-12-0619-01A-01D-1492-08		7578440	73616770	49	7781											
MYOCD	93649	broad.mit.edu	37	chr17	12655804	12655804	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaacggctctcatggaccGgcttcgacccttccaggact	9	15	1	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr17:12655804G>A	uc002gnn.2	+	10	1498	c.1199G>A	c.(1198-1200)CGG>CAG	p.R400Q	MYOCD_uc002gno.2_Missense_Mutation_p.R400Q|MYOCD_uc002gnp.1_Missense_Mutation_p.R304Q|MYOCD_uc002gnq.2_Missense_Mutation_p.R119Q	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	400	SAP.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CTCATGGACCGGCTTCGACCC	0.507													A	12655804	A	A	12655804	3	1	114	1	0	0	0	0	1	0	0	0	10087	1116	39	2	1237	2	MYOCD	17	12655804	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	5077364	12655804	68539406	50	7782											
KRT12	3859	broad.mit.edu	37	chr17	39019850	39019850	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttggtgctaatctccttacGgagctccccgctctgcaaca	9	14	2	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr17:39019850G>A	uc002hvk.2	-	5	1006	c.982C>T	c.(982-984)CGT>TGT	p.R328C		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	328	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				ATCTCCTTACGGAGCTCCCCG	0.567													A	39019850	A	A	39019850	3	1	114	1	0	0	0	0	1	0	0	0	8449	1116	39	2	518	2	KRT12	17	39019850	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	26364046	39019850	42175360	51	7783											
COL1A1	1277	broad.mit.edu	37	chr17	48275131	48275131	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggggacctgggggacctcGgggacccatgggaccctaga	18	11	0	1	rs72667036		TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr17:48275131G>A	uc002iqm.2	-	9	784	c.658C>T	c.(658-660)CGA>TGA	p.R220*		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	220	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding	p.R220*(1)	COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	GGGGGACCTCGGGGACCCATG	0.507			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						A	48275131	A	A	48275131	4	1	114	1	0	0	0	0	0	1	0	0	3677	1124	39	2	3908	2	COL1A1	17	48275131	Nonsense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	9255281	48275131	32920079	52	7784											
ABCA6	23460	broad.mit.edu	37	chr17	67098976	67098976	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagcaaaaaggcaaacatacCttttgtttaccagaaactat	5	8	0	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr17:67098976C>A	uc002jhw.1	-	21	3049	c.2874G>T	c.(2872-2874)AAG>AAT	p.K958N		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	958					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					GCAAACATACCTTTTGTTTAC	0.313													A	67098976	A	A	67098976	3	1	114	1	0	0	0	0	1	0	0	0	36	695	24	5	2055	5	ABCA6	17	67098976	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	18823845	67098976	14096234	53	7785											
SDK2	54549	broad.mit.edu	37	chr17	71426663	71426663	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtacctgatggttactcGggggtcgtgggtcactccgc	14	12	1	1	rs147877604		TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr17:71426663G>A	uc010dfm.2	-	12	1570	c.1570C>T	c.(1570-1572)CGA>TGA	p.R524*	SDK2_uc010dfn.2_Nonsense_Mutation_p.R203*	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	524	Extracellular (Potential).|Ig-like C2-type 6.				cell adhesion	integral to membrane				ovary(2)	2						ATGGTTACTCGGGGGTCGTGG	0.602													A	71426663	A	A	71426663	4	1	114	1	0	0	0	0	0	1	0	0	13969	1124	39	2	5084	2	SDK2	17	71426663	Nonsense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	4327687	71426663	9768547	54	7786											
CELF4	56853	broad.mit.edu	37	chr18	34853005	34853005	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggggtcataggtgcggccGccaggccattcatgttgagg	16	9	2	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr18:34853005G>A	uc002lae.2	-	7	1319	c.923C>T	c.(922-924)GCG>GTG	p.A308V	CELF4_uc010dnd.1_Missense_Mutation_p.A306V|CELF4_uc002lag.2_Missense_Mutation_p.A298V|CELF4_uc002laf.2_Missense_Mutation_p.A303V|CELF4_uc002lai.2_Missense_Mutation_p.A293V|CELF4_uc002lah.1_Missense_Mutation_p.A33V|CELF4_uc002laj.1_Silent_p.G143G	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	308	Ala-rich.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding	p.A308V(1)		ovary(2)	2						AGGTGCGGCCGCCAGGCCATT	0.652													A	34853005	A	A	34853005	3	1	114	1	0	0	0	0	1	0	0	0	3218	1087	38	1	561	1	CELF4	18	34853005	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08		34853005	43224243	55	7787											
MUC16	94025	broad.mit.edu	37	chr19	9067037	9067037	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctggtgaaggcatcagggaAgaggagaagctggttttctc	16	6	2	3			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr19:9067037A>G	uc002mkp.2	-	3	20613	c.20409T>C	c.(20407-20409)TCT>TCC	p.S6803S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6805	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCATCAGGGAAGAGGAGAAGC	0.473													G	9067037	G	G	9067037	2	3	114	1	0	0	0	0	0	0	0	1	9973	59	3	4		4	MUC16	19	9067037	Silent	SNP	A	TCGA-12-0619-01A-01D-1492-08		9067037	50061946	56	7788											
GLT25D1	79709	broad.mit.edu	37	chr19	17679388	17679388	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggggctgctttgcagttcCcatggtgcactcgaccttcc	11	15	0	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr19:17679388C>T	uc002nhc.1	+	5	707	c.695C>T	c.(694-696)CCC>CTC	p.P232L	GLT25D1_uc010eax.1_5'UTR	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	232					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0						TTTGCAGTTCCCATGGTGCAC	0.617													T	17679388	T	T	17679388	3	4	114	1	0	0	0	0	1	0	0	0	6466	623	22	3	713	3	GLT25D1	19	17679388	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	8612351	17679388	41449595	57	7789											
RSPH6A	81492	broad.mit.edu	37	chr19	46318327	46318327	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctcctcggggtccgctgcCagggcctgagcttggtcccg	14	16	1	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr19:46318327C>T	uc002pdm.2	-	1	251	c.108G>A	c.(106-108)CTG>CTA	p.L36L		NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	36						intracellular				ovary(1)|central_nervous_system(1)	2						GGTCCGCTGCCAGGGCCTGAG	0.687													T	46318327	T	T	46318327	2	4	114	1	0	0	0	0	0	0	0	1	13707	581	21	3		3	RSPH6A	19	46318327	Silent	SNP	C	TCGA-12-0619-01A-01D-1492-08	28638939	46318327	12810656	58	7790											
SHANK1	50944	broad.mit.edu	37	chr19	51205808	51205808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccatgaaggagcgtccggGtaccgctgagtagagcttcc	14	11	0	3			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr19:51205808G>A	uc002psx.1	-	11	1682	c.1663C>T	c.(1663-1665)CCC>TCC	p.P555S		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	555	SH3.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GAGCGTCCGGGTACCGCTGAG	0.697													A	51205808	A	A	51205808	3	1	114	1	0	0	0	0	1	0	0	0	14264	1261	44	3	4874	3	SHANK1	19	51205808	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	4887481	51205808	7923175	59	7791											
GPR32	2854	broad.mit.edu	37	chr19	51274077	51274077	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgactgtcttccgtatggcaCgcacggtctccaccgtctgc	10	15	3	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr19:51274077C>T	uc010ycf.1	+	1	220	c.220C>T	c.(220-222)CGC>TGC	p.R74C		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	74	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CCGTATGGCACGCACGGTCTC	0.572													T	51274077	T	T	51274077	3	4	114	1	0	0	0	0	1	0	0	0	6688	536	19	1	222	1	GPR32	19	51274077	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	68269	51274077	7854906	60	7792											
TTYH1	57348	broad.mit.edu	37	chr19	54947301	54947304	+	Frame_Shift_Del	DEL	TCTA	-	-													gctttgtgcagtggcagtcgTctatctgagcccctcctccc							TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr19:54947301_54947304delTCTA	uc002qfq.2	+	13	1437_1440	c.1345_1348delTCTA	c.(1345-1350)TCTATCfs	p.S449fs	TTYH1_uc010yey.1_3'UTR|TTYH1_uc002qfr.2_Frame_Shift_Del_p.R433fs|TTYH1_uc002qft.2_Frame_Shift_Del_p.S450fs	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	449_450	Cytoplasmic (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GTGGCAGTCGTCTATCTGAGCCCC	0.632													-	54947304	-	-	54947301	7	5	114	1	0	1	0	1	0	0	0	0	16736	1667	58	0	1395	0	TTYH1	19	54947301	Frame_Shift_Del	DEL	TCTA	TCGA-12-0619-01A-01D-1492-08	3673224	54947301	4181682	61	7793											
SBK2	646643	broad.mit.edu	37	chr19	56047417	56047417	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcctcgtacctttctgaCgatgggtgaccagaaggacg	12	11	1	3			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr19:56047417C>T	uc010ygc.1	-	1	245	c.245G>A	c.(244-246)CGT>CAT	p.R82H		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	82	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0						ACCTTTCTGACGATGGGTGAC	0.572													T	56047417	T	T	56047417	3	4	114	1	0	0	0	0	1	0	0	0	13861	536	19	1	812	1	SBK2	19	56047417	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08	1100116	56047417	3081566	62	7794											
HCK	3055	broad.mit.edu	37	chr20	30672225	30672225	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctctgccagaaactgtcGgtgccctgcatgtcttccaa	11	13	2	1	rs147876395		TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr20:30672225G>A	uc002wxh.2	+	8	885	c.714G>A	c.(712-714)TCG>TCA	p.S238S	HCK_uc010gdy.2_Silent_p.S217S|HCK_uc002wxi.2_Silent_p.S216S	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	238	SH2.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.S217S(1)		lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGAAACTGTCGGTGCCCTGCA	0.587													A	30672225	A	A	30672225	2	1	114	1	0	0	0	0	0	0	0	1	6994	1103	39	2		2	HCK	20	30672225	Silent	SNP	G	TCGA-12-0619-01A-01D-1492-08		30672225	32353295	63	7795											
RIMBP3	85376	broad.mit.edu	37	chr22	20458191	20458191	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaaggtgtagcagctcacGcccgctggggtcagggcatg	17	10	2	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr22:20458191G>A	uc002zsd.3	-	1	3596	c.3111C>T	c.(3109-3111)GGC>GGT	p.G1037G		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			AGCAGCTCACGCCCGCTGGGG	0.642													A	20458191	A	A	20458191	2	1	114	1	0	0	0	0	0	0	0	1	13364	1074	38	1		1	RIMBP3	22	20458191	Silent	SNP	G	TCGA-12-0619-01A-01D-1492-08		20458191	30846375	64	7796											
CSF2RB	1439	broad.mit.edu	37	chr22	37326752	37326752	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtgctgagggaggggctcGgcagcctccacaccaggcac	15	14	0	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chr22:37326752G>A	uc003aqa.3	+	8	1109	c.892G>A	c.(892-894)GGC>AGC	p.G298S	CSF2RB_uc003aqc.3_Missense_Mutation_p.G304S	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	298	Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	GGAGGGGCTCGGCAGCCTCCA	0.647													A	37326752	A	A	37326752	3	1	114	1	0	0	0	0	1	0	0	0	3935	1116	39	2	918	2	CSF2RB	22	37326752	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	16868561	37326752	13977814	65	7797											
KLHL4	56062	broad.mit.edu	37	chrX	86887278	86887278	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atattggcaccatgaatggcCgtaggcttcaatttggagtc	11	8	1	1			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chrX:86887278C>A	uc004efb.2	+	7	1575	c.1393C>A	c.(1393-1395)CGT>AGT	p.R465S	KLHL4_uc004efa.2_Missense_Mutation_p.R465S	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	465	Kelch 1.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CATGAATGGCCGTAGGCTTCA	0.393													A	86887278	A	A	86887278	3	1	114	1	0	0	0	0	1	0	0	0	8391	652	23	5	1419	5	KLHL4	23	86887278	Missense_Mutation	SNP	C	TCGA-12-0619-01A-01D-1492-08		86887278	68383282	66	7798											
MAGEC2	51438	broad.mit.edu	37	chrX	141291741	141291741	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtcggggagtcgttgtcaacGttgcggaatggaacgcctgg	17	8	1	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chrX:141291741G>T	uc004fbu.1	-	3	381	c.33C>A	c.(31-33)AAC>AAA	p.N11K		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	11						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGTCAACGTTGCGGAATG	0.537										HNSCC(46;0.14)			T	141291741	T	T	141291741	3	4	114	1	0	0	0	0	1	0	0	0	9181	1136	40	5	1092	5	MAGEC2	23	141291741	Missense_Mutation	SNP	G	TCGA-12-0619-01A-01D-1492-08	54404463	141291741	13978819	67	7799											
CD99L2	83692	broad.mit.edu	37	chrX	149963729	149963729	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcatctcgatcatttcgaTcatccagggcatcagccaag	7	13	5	0			TCGA-12-0619-01A-01D-1492-08	TCGA-12-0619-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	79c65ab5-1924-4710-96e4-31e9a615a53e	3eae6dd0-7740-4b61-918a-5d7ba6eb042e	g.chrX:149963729T>C	uc004fel.2	-	6	498	c.380A>G	c.(379-381)GAT>GGT	p.D127G	CD99L2_uc004fek.2_RNA|CD99L2_uc004fem.2_Missense_Mutation_p.D78G|CD99L2_uc004fen.2_Missense_Mutation_p.D55G|CD99L2_uc004feo.2_RNA|CD99L2_uc011myb.1_Intron	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4	127	Extracellular (Potential).				cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATCATTTCGATCATCCAGGGC	0.448													C	149963729	C	C	149963729	3	2	114	1	0	0	0	0	1	0	0	0	3051	1435	50	4	432	4	CD99L2	23	149963729	Missense_Mutation	SNP	T	TCGA-12-0619-01A-01D-1492-08	8671988	149963729	5306831	68	7800											
PADI6	353238	broad.mit.edu	37	chr1	17699701	17699701	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacagtgaagatgacatcGcccagcccttccgtggatgc	11	14	0	3			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr1:17699701G>A	uc001bak.1	+	2	267	c.267G>A	c.(265-267)TCG>TCA	p.S89S		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	81					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AGATGACATCGCCCAGCCCTT	0.602													A	17699701	A	A	17699701	2	1	115	1	0	0	0	0	0	0	0	1	11381	1074	38	1		1	PADI6	1	17699701	Silent	SNP	G	TCGA-12-0688-01A-02D-1492-08		17699701	231550920	1	7801											
NOTCH2	4853	broad.mit.edu	37	chr1	120539904	120539904	+	Frame_Shift_Del	DEL	C	-	-													ccacagtggtacaggtacttCcatttgcacagggatgagac							TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr1:120539904delC	uc001eik.2	-	4	723	c.467delG	c.(466-468)GGAfs	p.G156fs	NOTCH2_uc001eil.2_Frame_Shift_Del_p.G156fs|NOTCH2_uc001eim.3_Frame_Shift_Del_p.G73fs	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	156	Extracellular (Potential).|EGF-like 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGGTACTTCCATTTGCACA	0.488			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				-	120539904	-	-	120539904	7	5	115	1	0	1	0	1	0	0	0	0	10548	855	30	0	7072	0	NOTCH2	1	120539904	Frame_Shift_Del	DEL	C	TCGA-12-0688-01A-02D-1492-08	102840203	120539904	128710717	2	7802											
HRNR	388697	broad.mit.edu	37	chr1	152193158	152193158	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgtggctggaggagtgccccGaaccggacccatgtcggacg	16	13	0	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr1:152193158G>A	uc001ezt.1	-	3	1023	c.947C>T	c.(946-948)TCG>TTG	p.S316L		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	316	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGTGCCCCGAACCGGACCC	0.607													A	152193158	A	A	152193158	3	1	115	1	0	0	0	0	1	0	0	0	7359	1059	37	2	7609	2	HRNR	1	152193158	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08	31653254	152193158	97057463	3	7803											
IVL	3713	broad.mit.edu	37	chr1	152883944	152883944	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caggtccaagacattcaaccAgccctgcccacaaagggaga	9	14	1	2			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr1:152883944A>C	uc001fau.2	+	2	1717	c.1671A>C	c.(1669-1671)CCA>CCC	p.P557P		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	557					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACATTCAACCAGCCCTGCCCA	0.398													C	152883944	C	C	152883944	2	2	115	1	0	0	0	0	0	0	0	1	7929	175	7	5		5	IVL	1	152883944	Silent	SNP	A	TCGA-12-0688-01A-02D-1492-08	690786	152883944	96366677	4	7804											
OR2T3	343173	broad.mit.edu	37	chr1	248636836	248636836	+	Frame_Shift_Del	DEL	C	-	-													ctcagagccccgcctccacaCccccatgtacttcttcatca							TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr1:248636836delC	uc001iel.1	+	1	185	c.185delC	c.(184-186)ACCfs	p.T62fs		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	62	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGCCTCCACACCCCCATGTAC	0.567													-	248636836	-	-	248636836	7	5	115	1	0	1	0	1	0	0	0	0	11023	507	18	0	187	0	OR2T3	1	248636836	Frame_Shift_Del	DEL	C	TCGA-12-0688-01A-02D-1492-08	95752892	248636836	613785	5	7805											
OR2T34	127068	broad.mit.edu	37	chr1	248737870	248737870	+	Frame_Shift_Del	DEL	G	-	-													tggctgatgaagaagtacatGggggtgtggaggcggggctc							TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr1:248737870delG	uc001iep.1	-	1	189	c.189delC	c.(187-189)CCCfs	p.P63fs		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGAAGTACATGGGGGTGTGGA	0.562													-	248737870	-	-	248737870	7	5	115	1	0	1	0	1	0	0	0	0	11025	1335	47	0	771	0	OR2T34	1	248737870	Frame_Shift_Del	DEL	G	TCGA-12-0688-01A-02D-1492-08	101034	248737870	512751	6	7806											
OR14I1	401994	broad.mit.edu	37	chr1	248845184	248845184	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccaggtggtgactgccatcTgatagcaccctcctgatgtc	11	13	1	3			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr1:248845184T>C	uc001ieu.1	-	1	422	c.422A>G	c.(421-423)CAG>CGG	p.Q141R		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	141	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GACTGCCATCTGATAGCACCC	0.542													C	248845184	C	C	248845184	3	2	115	1	0	0	0	0	1	0	0	0	10947	1580	55	4	517	4	OR14I1	1	248845184	Missense_Mutation	SNP	T	TCGA-12-0688-01A-02D-1492-08	107314	248845184	405437	7	7807											
VRK2	7444	broad.mit.edu	37	chr2	58373508	58373508	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggcacacaataggttaatcGaaaaaaaagtccacagtgag	9	7	0	1	rs139700760		TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr2:58373508G>A	uc002rzo.2	+	15	1826	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	VRK2_uc010fcb.2_Missense_Mutation_p.E361K|VRK2_uc002rzs.2_Missense_Mutation_p.E361K|VRK2_uc002rzr.2_Missense_Mutation_p.E361K|VRK2_uc010fcc.2_Missense_Mutation_p.E243K|VRK2_uc002rzv.2_Missense_Mutation_p.E361K|VRK2_uc010fcd.2_Missense_Mutation_p.E338K|VRK2_uc002rzp.2_Missense_Mutation_p.E361K|VRK2_uc010ypg.1_Missense_Mutation_p.E361K|VRK2_uc002rzq.2_Missense_Mutation_p.E361K|VRK2_uc002rzu.2_Missense_Mutation_p.E361K|VRK2_uc002rzt.2_Missense_Mutation_p.E243K	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	vaccinia related kinase 2 isoform 2	361						integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						TAGGTTAATCGAAAAAAAAGT	0.383													A	58373508	A	A	58373508	3	1	115	1	0	0	0	0	1	0	0	0	17217	1059	37	2	1123	2	VRK2	2	58373508	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08		58373508	184825865	8	7808											
CBLB	868	broad.mit.edu	37	chr3	105400636	105400636	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atggaccatgtgttccattcAgcatacagtgaccattatca	7	10	2	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr3:105400636A>G	uc003dwc.2	-	15	2550	c.2228T>C	c.(2227-2229)CTG>CCG	p.L743P	CBLB_uc003dwa.2_Missense_Mutation_p.L2P|CBLB_uc011bhi.1_Missense_Mutation_p.L765P|CBLB_uc003dwd.1_Missense_Mutation_p.L743P|CBLB_uc003dwe.1_Missense_Mutation_p.L743P	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	743	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TGTTCCATTCAGCATACAGTG	0.343			Mis S		AML								G	105400636	G	G	105400636	3	3	115	1	0	0	0	0	1	0	0	0	2701	188	7	4	740	4	CBLB	3	105400636	Missense_Mutation	SNP	A	TCGA-12-0688-01A-02D-1492-08		105400636	92621794	9	7809											
PHLDB2	90102	broad.mit.edu	37	chr3	111632481	111632481	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcagtgacctcacccggactCctccaccaccatcctccacc	4	22	2	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr3:111632481C>T	uc010hqa.2	+	3	2062	c.1651C>T	c.(1651-1653)CCT>TCT	p.P551S	PHLDB2_uc003dyc.2_Missense_Mutation_p.P578S|PHLDB2_uc003dyd.2_Missense_Mutation_p.P551S|PHLDB2_uc003dyg.2_Missense_Mutation_p.P551S|PHLDB2_uc003dyh.2_Missense_Mutation_p.P551S|PHLDB2_uc003dyi.2_Missense_Mutation_p.P137S|PHLDB2_uc003dyf.3_Missense_Mutation_p.P551S	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	551						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						CACCCGGACTCCTCCACCACC	0.512													T	111632481	T	T	111632481	3	4	115	1	0	0	0	0	1	0	0	0	11852	855	30	3	1742	3	PHLDB2	3	111632481	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	6231845	111632481	86389949	10	7810											
CCDC48	79825	broad.mit.edu	37	chr3	128757682	128757682	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttctttttaagaacatatcGaaaagagccctggggaagat	9	6	1	3			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr3:128757682G>A	uc011bkt.1	+	7	1599	c.1599G>A	c.(1597-1599)TCG>TCA	p.S533S		NM_024768	NP_079044	Q9HA90	CCD48_HUMAN	coiled-coil domain containing 48	533	Potential.										0						AGAACATATCGAAAAGAGCCC	0.552													A	128757682	A	A	128757682	2	1	115	1	0	0	0	0	0	0	0	1	2819	1045	37	2		2	CCDC48	3	128757682	Silent	SNP	G	TCGA-12-0688-01A-02D-1492-08	17125201	128757682	69264748	11	7811											
LRRC33	375387	broad.mit.edu	37	chr3	196388089	196388089	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggaacatgggcctccactcCagctttatggcgttggactt	11	11	0	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr3:196388089C>T	uc003fwv.2	+	3	1679	c.1575C>T	c.(1573-1575)TCC>TCT	p.S525S		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	525	Extracellular (Potential).|LRR 18.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		GCCTCCACTCCAGCTTTATGG	0.567													T	196388089	T	T	196388089	2	4	115	1	0	0	0	0	0	0	0	1	8988	581	21	3		3	LRRC33	3	196388089	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08	67630407	196388089	1634341	12	7812											
FGFBP2	83888	broad.mit.edu	37	chr4	15964315	15964315	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgggcctcagagatggcgtCccagcctcaggctgctggtt	14	12	2	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr4:15964315C>T	uc003gon.2	-	1	545	c.438G>A	c.(436-438)GGG>GGA	p.G146G		NM_031950	NP_114156	Q9BYJ0	FGFP2_HUMAN	killer-specific secretory protein of 37 kDa	146						extracellular space	growth factor binding				0						GAGATGGCGTCCCAGCCTCAG	0.617													T	15964315	T	T	15964315	2	4	115	1	0	0	0	0	0	0	0	1	5861	842	30	3		3	FGFBP2	4	15964315	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08		15964315	175189961	13	7813											
STAP1	26228	broad.mit.edu	37	chr4	68449405	68449405	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagaaactactccatcactaTtcggcaggagatagagtatg	9	8	1	3			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr4:68449405T>C	uc003hde.3	+	6	726	c.644T>C	c.(643-645)ATT>ACT	p.I215T	STAP1_uc003hdf.2_Missense_Mutation_p.I215T	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	215	SH2.				cellular membrane fusion|intracellular protein transport	cytoplasm					0						TCCATCACTATTCGGCAGGAG	0.408													C	68449405	C	C	68449405	3	2	115	1	0	0	0	0	1	0	0	0	15251	1493	52	4	666	4	STAP1	4	68449405	Missense_Mutation	SNP	T	TCGA-12-0688-01A-02D-1492-08	52485090	68449405	122704871	14	7814											
PDHA2	5161	broad.mit.edu	37	chr4	96761326	96761326	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggccgccttcatctcccgcGtgttgaggcgagttgcccag	13	14	2	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr4:96761326G>A	uc003htr.3	+	1	88	c.25G>A	c.(25-27)GTG>ATG	p.V9M		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	9					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CATCTCCCGCGTGTTGAGGCG	0.557													A	96761326	A	A	96761326	3	1	115	1	0	0	0	0	1	0	0	0	11665	1145	40	1	27	1	PDHA2	4	96761326	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08	28311921	96761326	94392950	15	7815											
EGF	1950	broad.mit.edu	37	chr4	110908980	110908980	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggatgccacatgtcagtgtTtgaaaggatttgctggggat	14	5	1	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr4:110908980T>C	uc003hzy.3	+	17	3024	c.2572T>C	c.(2572-2574)TTG>CTG	p.L858L	EGF_uc011cfu.1_Silent_p.L816L|EGF_uc011cfv.1_Silent_p.L858L|EGF_uc010imk.2_Intron	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	858	EGF-like 6.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ATGTCAGTGTTTGAAAGGATT	0.423													C	110908980	C	C	110908980	2	2	115	1	0	0	0	0	0	0	0	1	4962	1838	64	4		4	EGF	4	110908980	Silent	SNP	T	TCGA-12-0688-01A-02D-1492-08	14147654	110908980	80245296	16	7816											
SLC6A19	340024	broad.mit.edu	37	chr5	1217004	1217004	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgcaacgcctccgaccccGcggcctacgcgcagctggtg	14	17	0	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr5:1217004G>A	uc003jbw.3	+	8	1173	c.1117G>A	c.(1117-1119)GCG>ACG	p.A373T		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	373	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTCCGACCCCGCGGCCTACGC	0.622													A	1217004	A	A	1217004	3	1	115	1	0	0	0	0	1	0	0	0	14682	1087	38	1	1147	1	SLC6A19	5	1217004	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08		1217004	179698256	17	7817											
PIK3R1	5295	broad.mit.edu	37	chr5	67591086	67591086	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctgagtatcgagaaattgAcaaacgtatgaacagcatta	9	6	0	4			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr5:67591086A>G	uc003jva.2	+	13	2239	c.1679A>G	c.(1678-1680)GAC>GGC	p.D560G	PIK3R1_uc003jvb.2_Missense_Mutation_p.D560G|PIK3R1_uc003jvc.2_Missense_Mutation_p.D260G|PIK3R1_uc003jvd.2_Missense_Mutation_p.D290G|PIK3R1_uc003jve.2_Missense_Mutation_p.D239G|PIK3R1_uc011crb.1_Missense_Mutation_p.D230G	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	560					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D560_S565del(1)|p.R557_K561>Q(1)|p.D560Y(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CGAGAAATTGACAAACGTATG	0.358			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			G	67591086	G	G	67591086	3	3	115	1	0	0	0	0	1	0	0	0	11918	275	10	4	1855	4	PIK3R1	5	67591086	Missense_Mutation	SNP	A	TCGA-12-0688-01A-02D-1492-08	66374082	67591086	113324174	18	7818											
GRIA1	2890	broad.mit.edu	37	chr5	153065877	153065877	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgattgaaatgaaacatgaCggcatccgaaaggtaaggtc	12	6	0	4	rs140876127		TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr5:153065877C>T	uc003lva.3	+	8	1487	c.1122C>T	c.(1120-1122)GAC>GAT	p.D374D	GRIA1_uc003luy.3_Silent_p.D374D|GRIA1_uc003luz.3_Silent_p.D279D|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Silent_p.D294D|GRIA1_uc011dcx.1_Silent_p.D305D|GRIA1_uc011dcy.1_Silent_p.D384D|GRIA1_uc011dcz.1_Silent_p.D384D|GRIA1_uc010jia.1_Silent_p.D354D	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	374	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGAAACATGACGGCATCCGAA	0.502													T	153065877	T	T	153065877	2	4	115	1	0	0	0	0	0	0	0	1	6767	535	19	1		1	GRIA1	5	153065877	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08	85474791	153065877	27849383	19	7819											
FLT4	2324	broad.mit.edu	37	chr5	180048603	180048603	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcgccggtcttgcacttcGcacacatagtggccctcgtg	11	15	1	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr5:180048603G>A	uc003mma.3	-	13	2038	c.1959C>T	c.(1957-1959)TGC>TGT	p.C653C	FLT4_uc003mlz.3_Silent_p.C653C|FLT4_uc003mmb.1_Silent_p.C186C|FLT4_uc011dgy.1_Silent_p.C653C	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	653	Ig-like C2-type 6.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTTGCACTTCGCACACATAGT	0.697									Congenital_Hereditary_Lymphedema				A	180048603	A	A	180048603	2	1	115	1	0	0	0	0	0	0	0	1	5944	1079	38	1		1	FLT4	5	180048603	Silent	SNP	G	TCGA-12-0688-01A-02D-1492-08	26982726	180048603	866657	20	7820											
IRF4	3662	broad.mit.edu	37	chr6	397159	397159	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgaagctggagggactacGtcccggatcagccacacccg	12	15	1	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr6:397159G>A	uc003msz.3	+	5	657	c.544G>A	c.(544-546)GTC>ATC	p.V182I	IRF4_uc010jne.1_Missense_Mutation_p.V182I|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.V181I|IRF4_uc003mtc.1_Missense_Mutation_p.V12I	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	182					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		GAGGGACTACGTCCCGGATCA	0.567			T	IGH@	MM 								A	397159	A	A	397159	3	1	115	1	0	0	0	0	1	0	0	0	7832	1145	40	1	558	1	IRF4	6	397159	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08		397159	170717908	21	7821											
OR10C1	442194	broad.mit.edu	37	chr6	29407979	29407979	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccctatgtacttcttcctgCgcaccctctcggccttggag	8	17	2	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr6:29407979C>T	uc011dlp.1	+	1	187	c.187C>T	c.(187-189)CGC>TGC	p.R63C	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTTCTTCCTGCGCACCCTCTC	0.572													T	29407979	T	T	29407979	3	4	115	1	0	0	0	0	1	0	0	0	10898	768	27	1	189	1	OR10C1	6	29407979	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	29010820	29407979	141707088	22	7822											
C6orf126	389383	broad.mit.edu	37	chr6	35747188	35747188	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgggcttgacgtgcatatcCaaggacttgatgtgttcccg	12	9	0	2			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr6:35747188C>A	uc010jvz.1	+	3	268	c.264C>A	c.(262-264)TCC>TCA	p.S88S	C6orf126_uc003olc.1_Missense_Mutation_p.Q115K|C6orf127_uc003old.3_5'Flank	NM_207409	NP_997292	Q6UWE3	CF126_HUMAN	hypothetical protein LOC389383 precursor	88					digestion|lipid catabolic process	extracellular region	enzyme activator activity				0						CGTGCATATCCAAGGACTTGA	0.567													A	35747188	A	A	35747188	2	1	115	1	0	0	0	0	0	0	0	1	2326	581	21	5		5	C6orf126	6	35747188	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08	6339209	35747188	135367879	23	7823											
NFKBIE	4794	broad.mit.edu	37	chr6	44229489	44229489	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggccacatgaagggctgtgtCaccatgccggtcctgtagtg	14	11	1	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr6:44229489C>T	uc003oxe.1	-	3	1007	c.982G>A	c.(982-984)GAC>AAC	p.D328N		NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	328	ANK 3.				cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGGGCTGTGTCACCATGCCGG	0.652													T	44229489	T	T	44229489	3	4	115	1	0	0	0	0	1	0	0	0	10380	826	29	3	536	3	NFKBIE	6	44229489	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	8482301	44229489	126885578	24	7824											
FAM83B	222584	broad.mit.edu	37	chr6	54806091	54806091	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaaaaaggggtctcagaaGttaaggtcattacttagcct	10	6	2	2			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr6:54806091G>A	uc003pck.2	+	5	2438	c.2322G>A	c.(2320-2322)AAG>AAA	p.K774K		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	774										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					GGTCTCAGAAGTTAAGGTCAT	0.363													A	54806091	A	A	54806091	2	1	115	1	0	0	0	0	0	0	0	1	5634	1020	36	3		3	FAM83B	6	54806091	Silent	SNP	G	TCGA-12-0688-01A-02D-1492-08	10576602	54806091	116308976	25	7825											
C6orf186	728464	broad.mit.edu	37	chr6	110567207	110567207	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctacttgcattgaaaatgTctttcttcaagaatagctga	7	7	3	3			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr6:110567207T>G	uc010kdu.1	-	5	1043	c.1043A>C	c.(1042-1044)GAC>GCC	p.D348A	C6orf186_uc003pub.2_Missense_Mutation_p.D151A	NM_001123364	NP_001116836	Q5JXM2	CF186_HUMAN	chromosome 6 open reading frame 186 precursor	348						extracellular region					0						ATTGAAAATGTCTTTCTTCAA	0.373													G	110567207	G	G	110567207	3	3	115	1	0	0	0	0	1	0	0	0	2347	1667	58	5	61	5	C6orf186	6	110567207	Missense_Mutation	SNP	T	TCGA-12-0688-01A-02D-1492-08	55761116	110567207	60547860	26	7826											
LPA	4018	broad.mit.edu	37	chr6	161006177	161006177	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tagtggtggagagtgtgcctCgataactctgtccatcacct	11	10	2	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr6:161006177C>T	uc003qtl.2	-	27	4310	c.4190G>A	c.(4189-4191)CGA>CAA	p.R1397Q		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3905	Kringle 35.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GAGTGTGCCTCGATAACTCTG	0.468													T	161006177	T	T	161006177	3	4	115	1	0	0	0	0	1	0	0	0	8903	884	31	2	1988	2	LPA	6	161006177	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	50438970	161006177	10108890	27	7827											
C7orf27	221927	broad.mit.edu	37	chr7	2580983	2580983	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagggctgctcgctggacccGgacgcagcccgccagggtcc	16	16	0	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr7:2580983G>A	uc003smi.2	-	9	1312	c.1270C>T	c.(1270-1272)CGG>TGG	p.R424W	C7orf27_uc003smh.3_5'UTR	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	424					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		CGCTGGACCCGGACGCAGCCC	0.682													A	2580983	A	A	2580983	3	1	115	1	0	0	0	0	1	0	0	0	2382	1115	39	2	1219	2	C7orf27	7	2580983	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08		2580983	156557680	28	7828											
SP4	6671	broad.mit.edu	37	chr7	21550871	21550871	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aactcccaatgtttcaaccaAcatggaagaattctgaaaag	6	9	2	2			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr7:21550871A>G	uc003sva.2	+	6	2520	c.2339A>G	c.(2338-2340)AAC>AGC	p.N780S	SP4_uc003svb.2_Missense_Mutation_p.N467S	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	780					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						GTTTCAACCAACATGGAAGAA	0.423													G	21550871	G	G	21550871	3	3	115	1	0	0	0	0	1	0	0	0	14966	43	2	4	2361	4	SP4	7	21550871	Missense_Mutation	SNP	A	TCGA-12-0688-01A-02D-1492-08	18969888	21550871	137587792	29	7829											
PDE1C	5137	broad.mit.edu	37	chr7	32091191	32091191	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggacgttttcttatatttccTcctgtaagaaaaggcataaa	7	7	1	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr7:32091191T>C	uc003tcm.1	-	2	572	c.103A>G	c.(103-105)AGG>GGG	p.R35G	PDE1C_uc003tcn.1_Missense_Mutation_p.R35G|PDE1C_uc003tco.1_Intron|PDE1C_uc003tcr.2_Missense_Mutation_p.R35G|PDE1C_uc003tcs.2_Missense_Mutation_p.R35G	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	35					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TTATATTTCCTCCTGTAAGAA	0.468													C	32091191	C	C	32091191	3	2	115	1	0	0	0	0	1	0	0	0	11635	1565	54	4	1865	4	PDE1C	7	32091191	Missense_Mutation	SNP	T	TCGA-12-0688-01A-02D-1492-08	10540320	32091191	127047472	30	7830											
ASL	435	broad.mit.edu	37	chr7	65554649	65554649	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gacactatgagtgccgtgctCcaggtggccactggcgtcat	13	12	1	1	rs140532520	byFrequency	TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr7:65554649C>G	uc003tuo.2	+	14	1140	c.1029C>G	c.(1027-1029)CTC>CTG	p.L343L	ASL_uc003tup.2_Silent_p.L343L|ASL_uc003tur.2_Silent_p.L317L|ASL_uc003tuq.2_Silent_p.L323L	NM_000048	NP_000039	P04424	ARLY_HUMAN	argininosuccinate lyase isoform 1	343					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)	GTGCCGTGCTCCAGGTGGCCA	0.637													G	65554649	G	G	65554649	2	3	115	1	0	0	0	0	0	0	0	1	1044	842	30	5		5	ASL	7	65554649	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08	33463458	65554649	93584014	31	7831											
CNTNAP2	26047	broad.mit.edu	37	chr7	148112574	148112574	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgatccggtacatgttcCgccacaagggcacctaccat	8	15	0	1	rs138661307		TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr7:148112574C>T	uc003weu.1	+	24	4378	c.3862C>T	c.(3862-3864)CGC>TGC	p.R1288C	CNTNAP2_uc003wev.1_Missense_Mutation_p.R65C	NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1288	Cytoplasmic (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.R1288C(1)		ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTACATGTTCCGCCACAAGGG	0.567										HNSCC(39;0.1)			T	148112574	T	T	148112574	3	4	115	1	0	0	0	0	1	0	0	0	3647	652	23	2	3956	2	CNTNAP2	7	148112574	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	82557925	148112574	11026089	32	7832											
PXDNL	137902	broad.mit.edu	37	chr8	52321474	52321474	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gagagcctgggattcccgctCcgagctcccgtaaacgttgg	13	13	0	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr8:52321474C>A	uc003xqu.3	-	17	2811	c.2710G>T	c.(2710-2712)GAG>TAG	p.E904*	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	904					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GATTCCCGCTCCGAGCTCCCG	0.592													A	52321474	A	A	52321474	4	1	115	1	0	0	0	0	0	1	0	0	12848	864	30	5	1709	5	PXDNL	8	52321474	Nonsense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08		52321474	94042548	33	7833											
DCAF13	25879	broad.mit.edu	37	chr8	104452461	104452461	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatctgatgaaatgaacattCgcctgtggaaagctaatgct	10	7	1	3			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr8:104452461C>T	uc003yln.2	+	9	1781	c.1504C>T	c.(1504-1506)CGC>TGC	p.R502C	DCAF13_uc003ylm.1_Missense_Mutation_p.R235C|DCAF13_uc003ylo.2_Missense_Mutation_p.R213C	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	WD repeats and SOF1 domain containing	350	WD 7.				rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1						AATGAACATTCGCCTGTGGAA	0.328													T	104452461	T	T	104452461	3	4	115	1	0	0	0	0	1	0	0	0	4266	884	31	2	1538	2	DCAF13	8	104452461	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	52130987	104452461	41911561	34	7834											
TM7SF4	81501	broad.mit.edu	37	chr8	105360771	105360771	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctttttcattttcaggaCgcagggagcatgggtatctg	11	7	4	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr8:105360771C>T	uc003ylx.1	+	2	40	c.-9C>T	c.(-11--7)GACGC>GATGC			NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein						osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATTTTCAGGACGCAGGGAGCA	0.393													T	105360771	T	T	105360771	1	4	115	1	0	0	0	0	0	0	0	0	15973	551	19	1		1	TM7SF4	8	105360771	Translation_Start_Site	SNP	C	TCGA-12-0688-01A-02D-1492-08	908310	105360771	41003251	35	7835											
TIGD5	84948	broad.mit.edu	37	chr8	144681263	144681263	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagctgcagacaccggatgGcgctgtgcgggtgctgttcc	17	11	0	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr8:144681263G>A	uc003yyx.1	+	1	1043	c.1043G>A	c.(1042-1044)GGC>GAC	p.G348D	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	397					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			ACACCGGATGGCGCTGTGCGG	0.692													A	144681263	A	A	144681263	3	1	115	1	0	0	0	0	1	0	0	0	15896	1203	42	3	1192	3	TIGD5	8	144681263	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08	39320492	144681263	1682759	36	7836											
FAM83H	286077	broad.mit.edu	37	chr8	144808805	144808805	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggccttcggggactccccGgagatggtaagggtgaggct	17	11	0	2			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr8:144808805G>A	uc003yzk.2	-	5	2895	c.2826C>T	c.(2824-2826)TCC>TCT	p.S942S	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	942					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGGACTCCCCGGAGATGGTAA	0.736													A	144808805	A	A	144808805	2	1	115	1	0	0	0	0	0	0	0	1	5640	1103	39	2		2	FAM83H	8	144808805	Silent	SNP	G	TCGA-12-0688-01A-02D-1492-08	127542	144808805	1555217	37	7837											
FAM75A3	727830	broad.mit.edu	37	chr9	40702725	40702725	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	accccccaggtgaggtgggcGaaagagcacctgatggagcc	15	12	0	3			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr9:40702725G>A	uc010mmj.2	+	4	411	c.382G>A	c.(382-384)GAA>AAA	p.E128K		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	128	Pro-rich.					integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TGAGGTGGGCGAAAGAGCACC	0.602													A	40702725	A	A	40702725	3	1	115	1	0	0	0	0	1	0	0	0	5621	1059	37	2	396	2	FAM75A3	9	40702725	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08		40702725	100510706	38	7838											
TRPM3	80036	broad.mit.edu	37	chr9	73399100	73399100	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcacagacaaccactggcaCgggaggggtgtctcgaaggt	14	10	2	1	rs141951214	byFrequency	TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr9:73399100C>T	uc004aid.2	-	7	1313	c.1069G>A	c.(1069-1071)GTG>ATG	p.V357M	TRPM3_uc004ahu.2_Missense_Mutation_p.V187M|TRPM3_uc004ahv.2_Missense_Mutation_p.V187M|TRPM3_uc004ahw.2_Missense_Mutation_p.V229M|TRPM3_uc004ahx.2_Missense_Mutation_p.V204M|TRPM3_uc004ahy.2_Missense_Mutation_p.V229M|TRPM3_uc004ahz.2_Missense_Mutation_p.V204M|TRPM3_uc004aia.2_Missense_Mutation_p.V204M|TRPM3_uc004aib.2_Missense_Mutation_p.V204M|TRPM3_uc004aic.2_Missense_Mutation_p.V357M|TRPM3_uc010mor.2_Missense_Mutation_p.V357M|TRPM3_uc004aie.2_Missense_Mutation_p.V204M|TRPM3_uc004aif.2_Missense_Mutation_p.V229M|TRPM3_uc004aig.2_Missense_Mutation_p.V204M	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	382	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						ACCACTGGCACGGGAGGGGTG	0.547													T	73399100	T	T	73399100	3	4	115	1	0	0	0	0	1	0	0	0	16584	536	19	1	4174	1	TRPM3	9	73399100	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	32696375	73399100	67814331	39	7839											
ROR2	4920	broad.mit.edu	37	chr9	94486082	94486082	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gccccatcttctggggcgttCtgtgtgtcatcagcgccctc	11	15	5	0	rs141070315		TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr9:94486082C>T	uc004arj.1	-	9	2893	c.2694G>A	c.(2692-2694)CAG>CAA	p.Q898Q	ROR2_uc004ari.1_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	898	Cytoplasmic (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						CTGGGGCGTTCTGTGTGTCAT	0.637													T	94486082	T	T	94486082	2	4	115	1	0	0	0	0	0	0	0	1	13527	912	32	3		3	ROR2	9	94486082	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08	21086982	94486082	46727349	40	7840											
OR1L1	26737	broad.mit.edu	37	chr9	125424265	125424265	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acttcttatcagagacaaagAccatctcttacagtgagtgt	7	9	3	3			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr9:125424265A>G	uc011lza.1	+	1	421	c.421A>G	c.(421-423)ACC>GCC	p.T141A		NM_001005236	NP_001005236	Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L,	141	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						AGAGACAAAGACCATCTCTTA	0.433													G	125424265	G	G	125424265	3	3	115	1	0	0	0	0	1	0	0	0	10963	275	10	4	273	4	OR1L1	9	125424265	Missense_Mutation	SNP	A	TCGA-12-0688-01A-02D-1492-08	30938183	125424265	15789166	41	7841											
EXD3	54932	broad.mit.edu	37	chr9	140201420	140201420	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcagaagggactgctggcCgggctgggggctgggctcgg	20	11	1	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr9:140201420C>T	uc004cmp.2	-	22	2809	c.2613G>A	c.(2611-2613)CCG>CCA	p.P871P	C9orf167_uc011mew.1_Intron|EXD3_uc010ncf.1_Silent_p.P509P	NM_017820	NP_060290	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	871					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						GACTGCTGGCCGGGCTGGGGG	0.652													T	140201420	T	T	140201420	2	4	115	1	0	0	0	0	0	0	0	1	5299	639	23	2		2	EXD3	9	140201420	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08	14777155	140201420	1012011	42	7842											
MS4A3	932	broad.mit.edu	37	chr11	59828736	59828736	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agctgaatacttctgtctacCagcccatagatggatcacca	7	12	3	2			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr11:59828736C>A	uc001nom.2	+	2	231	c.103C>A	c.(103-105)CAG>AAG	p.Q35K	MS4A3_uc001non.2_Missense_Mutation_p.Q35K|MS4A3_uc001noo.2_Intron	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	35	Cytoplasmic (Potential).			Q -> H (in Ref. 1; AAA62319).		endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				TTCTGTCTACCAGCCCATAGA	0.473													A	59828736	A	A	59828736	3	1	115	1	0	0	0	0	1	0	0	0	9861	595	21	5	105	5	MS4A3	11	59828736	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08		59828736	75177780	43	7843											
SLC22A6	9356	broad.mit.edu	37	chr11	62749352	62749352	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcaaaaaaaggcgcagagacCagtagctgcaggtggcgcca	14	10	0	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr11:62749352C>A	uc001nwk.2	-	4	1066	c.759G>T	c.(757-759)CTG>CTT	p.L253L	SLC22A6_uc001nwl.2_Silent_p.L253L|SLC22A6_uc001nwj.2_Silent_p.L253L|SLC22A6_uc001nwm.2_Silent_p.L253L	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	253	Helical; (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						GCGCAGAGACCAGTAGCTGCA	0.617													A	62749352	A	A	62749352	2	1	115	1	0	0	0	0	0	0	0	1	14458	581	21	5		5	SLC22A6	11	62749352	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08	2920616	62749352	72257164	44	7844											
MMP13	4322	broad.mit.edu	37	chr11	102825250	102825250	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aagtctggtaaaattcagagGagttacatcggaccaaactt	9	7	2	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr11:102825250G>A	uc001phl.2	-	3	476	c.448C>T	c.(448-450)CCT>TCT	p.P150S		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	150					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		AAATTCAGAGGAGTTACATCG	0.343													A	102825250	A	A	102825250	3	1	115	1	0	0	0	0	1	0	0	0	9652	1174	41	3	999	3	MMP13	11	102825250	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08	40075898	102825250	32181266	45	7845											
GPRC5A	9052	broad.mit.edu	37	chr12	13061399	13061399	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctactcagtttctcttcctCctgggtgtgttgggcatctt	9	12	3	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr12:13061399C>T	uc001rba.2	+	2	866	c.216C>T	c.(214-216)CTC>CTT	p.L72L	GPRC5A_uc001raz.2_Silent_p.L72L	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	72	Helical; Name=2; (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	TTCTCTTCCTCCTGGGTGTGT	0.557													T	13061399	T	T	13061399	2	4	115	1	0	0	0	0	0	0	0	1	6724	842	30	3		3	GPRC5A	12	13061399	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08		13061399	120790496	46	7846											
ATF7IP	55729	broad.mit.edu	37	chr12	14599967	14599967	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gctttgaagcagccaaagaaGatcttaagaaaagacatgaa	9	6	1	6			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr12:14599967G>T	uc001rbw.2	+	6	2133	c.1975G>T	c.(1975-1977)GAT>TAT	p.D659Y	ATF7IP_uc010shs.1_Missense_Mutation_p.D658Y|ATF7IP_uc001rbu.2_Missense_Mutation_p.D659Y|ATF7IP_uc001rbv.1_Missense_Mutation_p.D658Y|ATF7IP_uc001rbx.2_Missense_Mutation_p.D658Y|ATF7IP_uc010sht.1_Missense_Mutation_p.D659Y|ATF7IP_uc001rby.3_Missense_Mutation_p.D659Y|ATF7IP_uc001rca.2_Missense_Mutation_p.D659Y	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	659	Interaction with SETDB1.|Potential.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						AGCCAAAGAAGATCTTAAGAA	0.308													T	14599967	T	T	14599967	3	4	115	1	0	0	0	0	1	0	0	0	1087	942	33	5	1993	5	ATF7IP	12	14599967	Missense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08	1538568	14599967	119251928	47	7847											
SYNE2	23224	broad.mit.edu	37	chr14	64634098	64634098	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacggccacggcactggagCgctgcaggttagaacatccc	12	15	0	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr14:64634098C>T	uc001xgm.2	+	91	16983	c.16753C>T	c.(16753-16755)CGC>TGC	p.R5585C	SYNE2_uc001xgl.2_Missense_Mutation_p.R5585C|SYNE2_uc010apy.2_Missense_Mutation_p.R1970C|SYNE2_uc001xgn.2_Missense_Mutation_p.R547C|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_5'UTR|SYNE2_uc001xgq.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5585	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GGCACTGGAGCGCTGCAGGTT	0.478													T	64634098	T	T	64634098	3	4	115	1	0	0	0	0	1	0	0	0	15443	768	27	1	17111	1	SYNE2	14	64634098	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08		64634098	42715442	48	7848											
WDR72	256764	broad.mit.edu	37	chr15	53889439	53889439	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcatgtgttgttgaacttcCgccaagagaacagcttgtat	9	8	1	2			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr15:53889439C>T	uc002acj.2	-	18	3027	c.2985G>A	c.(2983-2985)GCG>GCA	p.A995A		NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	995										lung(1)|skin(1)	2				all cancers(107;0.0511)		GTTGAACTTCCGCCAAGAGAA	0.378													T	53889439	T	T	53889439	2	4	115	1	0	0	0	0	0	0	0	1	17319	639	23	2		2	WDR72	15	53889439	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08		53889439	48641953	49	7849											
C16orf53	79447	broad.mit.edu	37	chr16	29827999	29828009	+	Frame_Shift_Del	DEL	AGGAGGCCGAG	-	-													aaggccgaggacgagggggaAggaggccgagaggagaccga							TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr16:29827999_29828009delAGGAGGCCGAG	uc002dug.3	+	1	472_482	c.153_163delAGGAGGCCGAG	c.(151-165)GAAGGAGGCCGAGAGfs	p.E51fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_024516	NP_078792	Q9BTK6	PA1_HUMAN	PTIP-associated 1 protein	51_55	Glu-rich.										0						ACGAGGGGGAAGGAGGCCGAGAGGAGACCGA	0.697											OREG0023722	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	29828009	-	-	29827999	7	5	115	1	0	1	0	1	0	0	0	0	1818	69	3	0	155	0	C16orf53	16	29827999	Frame_Shift_Del	DEL	AGGAGGCCGAG	TCGA-12-0688-01A-02D-1492-08		29827999	60526754	50	7850											
FAM65A	79567	broad.mit.edu	37	chr16	67572596	67572596	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtttcccggtcttcagcccGccggggcccccacggaagcc	12	18	2	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr16:67572596G>A	uc010vjp.1	+	3	282	c.186G>A	c.(184-186)CCG>CCA	p.P62P	FAM65A_uc010cei.1_5'UTR|FAM65A_uc002eth.2_Silent_p.P42P|FAM65A_uc010cej.2_Silent_p.P45P|FAM65A_uc002eti.1_Intron|FAM65A_uc010vjq.1_Silent_p.P56P|FAM65A_uc002etj.1_Silent_p.P41P|FAM65A_uc002etk.2_Silent_p.P41P	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	46						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		TCTTCAGCCCGCCGGGGCCCC	0.682													A	67572596	A	A	67572596	2	1	115	1	0	0	0	0	0	0	0	1	5599	1074	38	1		1	FAM65A	16	67572596	Silent	SNP	G	TCGA-12-0688-01A-02D-1492-08	37744597	67572596	22782157	51	7851											
LRRC37B	114659	broad.mit.edu	37	chr17	30348508	30348508	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccctggggccagagccgttcTtggctgcacatcaggactta	12	13	2	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr17:30348508T>C	uc002hgu.2	+	1	354	c.343T>C	c.(343-345)TTG>CTG	p.L115L	LRRC37B_uc010wbx.1_Silent_p.L33L|LRRC37B_uc010csu.2_Silent_p.L115L	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	115	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				AGAGCCGTTCTTGGCTGCACA	0.547													C	30348508	C	C	30348508	2	2	115	1	0	0	0	0	0	0	0	1	8994	1606	56	4		4	LRRC37B	17	30348508	Silent	SNP	T	TCGA-12-0688-01A-02D-1492-08		30348508	50846702	52	7852											
G6PC3	92579	broad.mit.edu	37	chr17	42152338	42152338	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttgcctctcttctttctagcCgctgggtaagggtgatgcct	11	11	3	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr17:42152338C>A	uc002iex.2	+	4	634	c.418C>A	c.(418-420)CGC>AGC	p.R140S	G6PC3_uc002iey.2_Missense_Mutation_p.R15S|G6PC3_uc010czo.2_5'UTR|G6PC3_uc002iez.2_Missense_Mutation_p.R15S|G6PC3_uc002ifb.2_Missense_Mutation_p.R15S|G6PC3_uc002ifc.2_Intron	NM_138387	NP_612396	Q9BUM1	G6PC3_HUMAN	glucose-6-phosphatase catalytic subunit 3	140	Cytoplasmic (Potential).				gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			skin(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TCTTTCTAGCCGCTGGGTAAG	0.542													A	42152338	A	A	42152338	3	1	115	1	0	0	0	0	1	0	0	0	6145	666	23	5	432	5	G6PC3	17	42152338	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	11803830	42152338	39042872	53	7853											
RALBP1	10928	broad.mit.edu	37	chr18	9516893	9516893	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctctggagatgaggcagaaAgtccttctaaaatgaagagg	13	6	2	5			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr18:9516893A>G	uc002kob.2	+	3	518	c.295A>G	c.(295-297)AGT>GGT	p.S99G	RALBP1_uc002koc.2_Missense_Mutation_p.S99G	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	99					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						TGAGGCAGAAAGTCCTTCTAA	0.323													G	9516893	G	G	9516893	3	3	115	1	0	0	0	0	1	0	0	0	13012	72	3	4	301	4	RALBP1	18	9516893	Missense_Mutation	SNP	A	TCGA-12-0688-01A-02D-1492-08		9516893	68560355	54	7854											
PTPN2	5771	broad.mit.edu	37	chr18	12794472	12794472	+	Frame_Shift_Del	DEL	T	-	-													tttctgtcctctcgaatacgTttccgtagagcactatgagg							TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr18:12794472delT	uc002krp.2	-	9	1247	c.1053delA	c.(1051-1053)AAAfs	p.K351fs	PTPN2_uc002krl.2_Frame_Shift_Del_p.K351fs|PTPN2_uc002krn.2_Frame_Shift_Del_p.K374fs|PTPN2_uc002kro.2_Frame_Shift_Del_p.K351fs|PTPN2_uc002krm.2_Intron	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	351					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)				CTCGAATACGTTTCCGTAGAG	0.428													-	12794472	-	-	12794472	7	5	115	1	0	1	0	1	0	0	0	0	12785	1722	60	0	224	0	PTPN2	18	12794472	Frame_Shift_Del	DEL	T	TCGA-12-0688-01A-02D-1492-08	3277579	12794472	65282776	55	7855											
GATA6	2627	broad.mit.edu	37	chr18	19762971	19762971	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcagatgattgcagcaaaaaTacttcccccacaacacaacc	4	14	1	2			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr18:19762971T>A	uc002ktt.1	+	6	1852	c.1587T>A	c.(1585-1587)AAT>AAA	p.N529K	GATA6_uc002ktu.1_Missense_Mutation_p.N529K	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	529					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			GCAGCAAAAATACTTCCCCCA	0.373													A	19762971	A	A	19762971	3	1	115	1	0	0	0	0	1	0	0	0	6258	1403	49	5	1605	5	GATA6	18	19762971	Missense_Mutation	SNP	T	TCGA-12-0688-01A-02D-1492-08	6968499	19762971	58314277	56	7856											
CDH2	1000	broad.mit.edu	37	chr18	25591942	25591942	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttgggaacactatttcttcAacttctgctgactcctttac	5	12	3	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr18:25591942A>C	uc002kwg.2	-	4	873	c.414T>G	c.(412-414)GTT>GTG	p.V138V	CDH2_uc010xbn.1_Silent_p.V107V	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	138					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CTATTTCTTCAACTTCTGCTG	0.388													C	25591942	C	C	25591942	2	2	115	1	0	0	0	0	0	0	0	1	3105	117	5	5		5	CDH2	18	25591942	Silent	SNP	A	TCGA-12-0688-01A-02D-1492-08	5828971	25591942	52485306	57	7857											
SBNO2	22904	broad.mit.edu	37	chr19	1113547	1113547	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacccacctccgccacccgcTgggggccgcccagctggtcg	12	21	0	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr19:1113547T>C	uc002lrk.3	-	19	2472	c.2234A>G	c.(2233-2235)CAG>CGG	p.Q745R	SBNO2_uc002lrj.3_Missense_Mutation_p.Q688R|SBNO2_uc010dse.2_Missense_Mutation_p.Q728R|SBNO2_uc010xgj.1_Intron	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	745					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCACCCGCTGGGGGCCGCC	0.697													C	1113547	C	C	1113547	3	2	115	1	0	0	0	0	1	0	0	0	13863	1580	55	4	1922	4	SBNO2	19	1113547	Missense_Mutation	SNP	T	TCGA-12-0688-01A-02D-1492-08		1113547	58015436	58	7858											
ZNF554	115196	broad.mit.edu	37	chr19	2833912	2833912	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atggatttggggaaaatggtAatctgagcccagcccttgtt	12	7	1	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr19:2833912A>T	uc002lwm.2	+	5	877	c.679A>T	c.(679-681)AAT>TAT	p.N227Y	ZNF554_uc002lwl.2_Missense_Mutation_p.N176Y	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	227					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAAATGGTAATCTGAGCCC	0.502													T	2833912	T	T	2833912	3	4	115	1	0	0	0	0	1	0	0	0	17982	362	13	5	697	5	ZNF554	19	2833912	Missense_Mutation	SNP	A	TCGA-12-0688-01A-02D-1492-08	1720365	2833912	56295071	59	7859											
MCOLN1	57192	broad.mit.edu	37	chr19	7591685	7591685	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtcactgggccggtatgcGtatgtccgtggtgggggtga	19	7	1	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr19:7591685G>A	uc002mgo.2	+	4	569	c.444G>A	c.(442-444)GCG>GCA	p.A148A	MCOLN1_uc002mgp.2_Missense_Mutation_p.R35H	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	148					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						GCCGGTATGCGTATGTCCGTG	0.537													A	7591685	A	A	7591685	2	1	115	1	0	0	0	0	0	0	0	1	9395	1132	40	1		1	MCOLN1	19	7591685	Silent	SNP	G	TCGA-12-0688-01A-02D-1492-08	4757773	7591685	51537298	60	7860											
CLEC4M	10332	broad.mit.edu	37	chr19	7832494	7832494	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcacgtggcaatgggtggaCggctcacctctgtcacccag	14	13	3	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr19:7832494C>T	uc002mih.2	+	7	1078	c.960C>T	c.(958-960)GAC>GAT	p.D320D	CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Silent_p.D276D|CLEC4M_uc010dvt.2_Silent_p.D297D|CLEC4M_uc010dvs.2_Silent_p.D319D|CLEC4M_uc010xjx.1_Silent_p.D292D|CLEC4M_uc002mhz.2_Intron|CLEC4M_uc002mic.2_Intron|CLEC4M_uc002mia.2_Silent_p.D207D	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	343	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						AATGGGTGGACGGCTCACCTC	0.562													T	7832494	T	T	7832494	2	4	115	1	0	0	0	0	0	0	0	1	3518	535	19	1		1	CLEC4M	19	7832494	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08	240809	7832494	51296489	61	7861											
CYP4F12	66002	broad.mit.edu	37	chr19	15795890	15795890	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctcaggccatgacaccaCggccagtggcctctcctggg	11	17	2	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr19:15795890C>T	uc002nbl.2	+	9	1059	c.998C>T	c.(997-999)ACG>ATG	p.T333M		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					CATGACACCACGGCCAGTGGC	0.627													T	15795890	T	T	15795890	3	4	115	1	0	0	0	0	1	0	0	0	4187	536	19	1	1028	1	CYP4F12	19	15795890	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	7963396	15795890	43333093	62	7862											
SBSN	374897	broad.mit.edu	37	chr19	36019170	36019170	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggagcaggagccgaccagaCgtgcaagatgcatattgctg	15	9	0	2	rs138249808		TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr19:36019170C>T	uc002oae.1	-	1	84	c.14G>A	c.(13-15)CGT>CAT	p.R5H	SBSN_uc002oad.1_Missense_Mutation_p.R5H	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	5						extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCCGACCAGACGTGCAAGATG	0.587													T	36019170	T	T	36019170	3	4	115	1	0	0	0	0	1	0	0	0	13864	536	19	1	1774	1	SBSN	19	36019170	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	20223280	36019170	23109813	63	7863											
FCGBP	8857	broad.mit.edu	37	chr19	40380305	40380305	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acgcaggtgcccatgaagtcGaagcggtggccatcgaaggt	15	10	0	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr19:40380305G>A	uc002omp.3	-	23	11018	c.11010C>T	c.(11008-11010)TTC>TTT	p.F3670F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	3670	VWFD 9.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCATGAAGTCGAAGCGGTGGC	0.672													A	40380305	A	A	40380305	2	1	115	1	0	0	0	0	0	0	0	1	5778	1049	37	2		2	FCGBP	19	40380305	Silent	SNP	G	TCGA-12-0688-01A-02D-1492-08	4361135	40380305	18748678	64	7864											
PRX	57716	broad.mit.edu	37	chr19	40902798	40902798	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctctggaagccgcacctcCggcacagccatctctggcac	9	18	2	0	rs140474860		TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr19:40902798C>T	uc002onr.2	-	7	1730	c.1461G>A	c.(1459-1461)CCG>CCA	p.P487P	PRX_uc002onq.2_Silent_p.P348P|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	487	9.|55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCGCACCTCCGGCACAGCCA	0.597													T	40902798	T	T	40902798	2	4	115	1	0	0	0	0	0	0	0	1	12642	639	23	2		2	PRX	19	40902798	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08	522493	40902798	18226185	65	7865											
ZNF816A	125893	broad.mit.edu	37	chr19	53453300	53453300	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgttgtgcaaggattcctttTtgattaaaaaccttcgcaca	7	8	0	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr19:53453300T>C	uc002qal.1	-	5	2029	c.1728A>G	c.(1726-1728)CAA>CAG	p.Q576Q	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Silent_p.Q560Q	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	576	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		GGATTCCTTTTTGATTAAAAA	0.388													C	53453300	C	C	53453300	2	2	115	1	0	0	0	0	0	0	0	1	18174	1838	64	4		4	ZNF816A	19	53453300	Silent	SNP	T	TCGA-12-0688-01A-02D-1492-08	12550502	53453300	5675683	66	7866											
RPN2	6185	broad.mit.edu	37	chr20	35835810	35835810	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgccagttgtggttgtgccTgagggctctgcttccgacac	14	11	1	1			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr20:35835810T>C	uc002xgp.2	+	7	1129	c.825T>C	c.(823-825)CCT>CCC	p.P275P	RPN2_uc002xgo.3_Silent_p.P275P|RPN2_uc010gfw.2_Silent_p.P118P|RPN2_uc002xgq.2_Silent_p.P243P	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	275	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TGGTTGTGCCTGAGGGCTCTG	0.537													C	35835810	C	C	35835810	2	2	115	1	0	0	0	0	0	0	0	1	13608	1567	55	4		4	RPN2	20	35835810	Silent	SNP	T	TCGA-12-0688-01A-02D-1492-08		35835810	27189710	67	7867											
SLC13A3	64849	broad.mit.edu	37	chr20	45194937	45194937	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcaaactcagtgaagaaggcGatgaccacagtgatgagcag	13	8	1	5	rs147641404		TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr20:45194937G>A	uc002xsf.1	-	11	1463	c.1425C>T	c.(1423-1425)ATC>ATT	p.I475I	SLC13A3_uc010ghn.1_Silent_p.I444I|SLC13A3_uc010zxw.1_Silent_p.I425I|SLC13A3_uc002xsg.1_Silent_p.I428I|SLC13A3_uc010gho.1_Silent_p.I393I|SLC13A3_uc010zxx.1_Silent_p.I377I|SLC13A3_uc002xse.1_5'Flank|SLC13A3_uc010ghm.1_Silent_p.I62I|SLC13A3_uc010zxv.1_Silent_p.I60I	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	475	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	TGAAGAAGGCGATGACCACAG	0.617													A	45194937	A	A	45194937	2	1	115	1	0	0	0	0	0	0	0	1	14393	1048	37	2		2	SLC13A3	20	45194937	Silent	SNP	G	TCGA-12-0688-01A-02D-1492-08	9359127	45194937	17830583	68	7868											
KCNG1	3755	broad.mit.edu	37	chr20	49626233	49626233	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gtgcggcctctccaccatgtCgcgcagtcgccgcatgcagc	12	17	1	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr20:49626233C>G	uc002xwa.3	-	2	938	c.643G>C	c.(643-645)GAC>CAC	p.D215H	KCNG1_uc002xwb.2_Missense_Mutation_p.D215H	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	215	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						TCCACCATGTCGCGCAGTCGC	0.726													G	49626233	G	G	49626233	3	3	115	1	0	0	0	0	1	0	0	0	8027	884	31	5	906	5	KCNG1	20	49626233	Missense_Mutation	SNP	C	TCGA-12-0688-01A-02D-1492-08	4431296	49626233	13399287	69	7869											
COL6A2	1292	broad.mit.edu	37	chr21	47532419	47532419	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgcacgagctctaccgcaaCgactacgccaccatgctgcc	8	19	1	0			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chr21:47532419C>T	uc002zia.1	+	3	724	c.642C>T	c.(640-642)AAC>AAT	p.N214N	COL6A2_uc002zhy.1_Silent_p.N214N|COL6A2_uc002zhz.1_Silent_p.N214N|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	214	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		TCTACCGCAACGACTACGCCA	0.667													T	47532419	T	T	47532419	2	4	115	1	0	0	0	0	0	0	0	1	3700	535	19	1		1	COL6A2	21	47532419	Silent	SNP	C	TCGA-12-0688-01A-02D-1492-08		47532419	597476	70	7870											
FGF13	2258	broad.mit.edu	37	chrX	137785220	137785220	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccttggatagccaccactcGcagacccacagggatgaggt	11	13	0	2			TCGA-12-0688-01A-02D-1492-08	TCGA-12-0688-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	143dc738-1694-4105-8115-9cc0902ef35b	634c7656-b172-4d88-a5a6-18389bc6dffe	g.chrX:137785220G>A	uc004fam.2	-	3	990	c.328C>T	c.(328-330)CGA>TGA	p.R110*	FGF13_uc004fan.2_Nonsense_Mutation_p.R57*|FGF13_uc011mwi.1_Nonsense_Mutation_p.R91*|FGF13_uc004faq.2_Nonsense_Mutation_p.R120*|FGF13_uc004far.2_Nonsense_Mutation_p.R91*|FGF13_uc011mwj.1_Nonsense_Mutation_p.R120*|FGF13_uc011mwk.1_Nonsense_Mutation_p.R64*	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	110					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCCACCACTCGCAGACCCACA	0.408													A	137785220	A	A	137785220	4	1	115	1	0	0	0	0	0	1	0	0	5842	1095	38	1	421	1	FGF13	23	137785220	Nonsense_Mutation	SNP	G	TCGA-12-0688-01A-02D-1492-08		137785220	17485340	71	7871											
AURKAIP1	54998	broad.mit.edu	37	chr1	1309242	1309242	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggggcttcctttagccccGccttcagccagatgcgcctc	11	17	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr1:1309242G>A	uc001afb.1	-	3	649	c.539C>T	c.(538-540)GCG>GTG	p.A180V	AURKAIP1_uc001afc.2_Missense_Mutation_p.A180V|AURKAIP1_uc001afd.2_Missense_Mutation_p.A180V|AURKAIP1_uc009vkb.1_Missense_Mutation_p.A180V	NM_017900	NP_060370	Q9NWT8	AKIP_HUMAN	aurora kinase A interacting protein 1	180					negative regulation of mitosis|positive regulation of proteolysis	mitochondrion|nucleus	protein binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.82e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CTTTAGCCCCGCCTTCAGCCA	0.597													A	1309242	A	A	1309242	3	1	116	1	0	0	0	0	1	0	0	0	1222	1087	38	1	64	1	AURKAIP1	1	1309242	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08		1309242	247941379	1	7872											
APITD1	378708	broad.mit.edu	37	chr1	10493980	10493980	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagagatgcagttcagcaaaCagaccattgcggccatttcg	10	10	1	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr1:10493980C>T	uc001are.2	+	2	549	c.133C>T	c.(133-135)CAG>TAG	p.Q45*	APITD1_uc001arf.2_Nonsense_Mutation_p.Q45*|APITD1_uc001arg.2_Missense_Mutation_p.T124I|APITD1_uc001arh.2_Nonsense_Mutation_p.Q6*	NM_199294	NP_954988	Q8N2Z9	CENPS_HUMAN	apoptosis-inducing, TAF9-like domain 1 isoform	45					DNA repair|mitotic prometaphase|transcription initiation, DNA-dependent	chromosome, centromeric region|cytosol|Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		GTTCAGCAAACAGACCATTGC	0.488													T	10493980	T	T	10493980	4	4	116	1	0	0	0	0	0	1	0	0	775	479	17	3	139	3	APITD1	1	10493980	Nonsense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	9184738	10493980	238756641	2	7873											
DIRAS3	9077	broad.mit.edu	37	chr1	68512685	68512685	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	taacgtggcgctgcagagcgCggttgccgtcgccactcttg	14	13	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr1:68512685C>G	uc001ded.2	-	2	591	c.296G>C	c.(295-297)CGC>CCC	p.R99P	uc001deb.1_Intron|uc001dec.1_Intron	NM_004675	NP_004666	O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	99					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						CTGCAGAGCGCGGTTGCCGTC	0.587													G	68512685	G	G	68512685	3	3	116	1	0	0	0	0	1	0	0	0	4532	768	27	5	397	5	DIRAS3	1	68512685	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	58018705	68512685	180737936	3	7874											
GON4L	54856	broad.mit.edu	37	chr1	155792117	155792117	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgactgctgttagattgtgcTgcttggcaccatcctccaag	10	11	0	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr1:155792117T>G	uc001flz.2	-	4	945	c.848A>C	c.(847-849)CAG>CCG	p.Q283P	GON4L_uc001fly.1_Missense_Mutation_p.Q283P|GON4L_uc009wrh.1_Missense_Mutation_p.Q283P|GON4L_uc001fma.1_Missense_Mutation_p.Q283P|GON4L_uc001fmc.2_Missense_Mutation_p.Q283P|GON4L_uc001fmd.3_Missense_Mutation_p.Q283P|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_Missense_Mutation_p.Q111P|GON4L_uc001fmf.2_5'Flank	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	283					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TAGATTGTGCTGCTTGGCACC	0.458													G	155792117	G	G	155792117	3	3	116	1	0	0	0	0	1	0	0	0	6572	1580	55	5	6107	5	GON4L	1	155792117	Missense_Mutation	SNP	T	TCGA-12-0692-01A-01W-0348-08	87279432	155792117	93458504	4	7875											
OLFML2B	25903	broad.mit.edu	37	chr1	161993080	161993080	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcctggttgtccgcctcGttttgcagagtctcgtcctc	9	14	2	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr1:161993080G>A	uc001gbu.2	-	1	565	c.141C>T	c.(139-141)AAC>AAT	p.N47N	OLFML2B_uc010pkq.1_Silent_p.N47N	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	47	Potential.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TGTCCGCCTCGTTTTGCAGAG	0.602													A	161993080	A	A	161993080	2	1	116	1	0	0	0	0	0	0	0	1	10858	1136	40	1		1	OLFML2B	1	161993080	Silent	SNP	G	TCGA-12-0692-01A-01W-0348-08	6200963	161993080	87257541	5	7876											
SMG7	9887	broad.mit.edu	37	chr1	183514093	183514093	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccccaacatatgttatcccCccgcctgtggcattttctat	5	16	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr1:183514093C>T	uc001gqg.2	+	16	2138	c.2016C>T	c.(2014-2016)CCC>CCT	p.P672P	SMG7_uc010pob.1_Silent_p.P655P|SMG7_uc001gqf.2_Silent_p.P626P|SMG7_uc001gqh.2_Silent_p.P626P|SMG7_uc001gqi.2_Silent_p.P584P|SMG7_uc010poc.1_Silent_p.P630P	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	672	Gln/Pro-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ATGTTATCCCCCCGCCTGTGG	0.443													T	183514093	T	T	183514093	2	4	116	1	0	0	0	0	0	0	0	1	14798	610	22	3		3	SMG7	1	183514093	Silent	SNP	C	TCGA-12-0692-01A-01W-0348-08	21521013	183514093	65736528	6	7877											
FAM129A	116496	broad.mit.edu	37	chr1	184787863	184787863	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtacacgtacttcactgaatCccgagctcactggtcccatg	8	14	2	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr1:184787863C>T	uc001gra.2	-	9	1276	c.1082G>A	c.(1081-1083)GGA>GAA	p.G361E	FAM129A_uc001grb.1_Missense_Mutation_p.G124E|FAM129A_uc009wyh.1_Missense_Mutation_p.G189E|FAM129A_uc009wyi.1_Missense_Mutation_p.G159E	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	361					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						TTCACTGAATCCCGAGCTCAC	0.537													T	184787863	T	T	184787863	3	4	116	1	0	0	0	0	1	0	0	0	5436	855	30	3	1728	3	FAM129A	1	184787863	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	1273770	184787863	64462758	7	7878											
CFHR4	10877	broad.mit.edu	37	chr1	196884097	196884097	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttttcagattcttcagaaAagtgtgggcctcctccacct	7	11	3	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr1:196884097A>C	uc001gto.2	+	5	697	c.628A>C	c.(628-630)AAG>CAG	p.K210Q	CFHR4_uc009wyy.2_Missense_Mutation_p.K456Q|CFHR4_uc001gtp.2_Missense_Mutation_p.K457Q	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	210	Sushi 4.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TTCTTCAGAAAAGTGTGGGCC	0.358													C	196884097	C	C	196884097	3	2	116	1	0	0	0	0	1	0	0	0	3287	15	1	5	646	5	CFHR4	1	196884097	Missense_Mutation	SNP	A	TCGA-12-0692-01A-01W-0348-08	12096234	196884097	52366524	8	7879											
HIST3H3	8290	broad.mit.edu	37	chr1	228612870	228612870	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtggacttctggtagcggcGgatctcgcgaagcgccaccg	15	12	2	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr1:228612870G>A	uc001hsx.1	-	1	157	c.157C>T	c.(157-159)CGC>TGC	p.R53C		NM_003493	NP_003484	Q16695	H31T_HUMAN	histone cluster 3, H3	53					nucleosome assembly|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		Prostate(94;0.0724)				TGGTAGCGGCGGATCTCGCGA	0.652													A	228612870	A	A	228612870	3	1	116	1	0	0	0	0	1	0	0	0	7184	1116	39	2	257	2	HIST3H3	1	228612870	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	31728773	228612870	20637751	9	7880											
ASB3	51130	broad.mit.edu	37	chr2	53941692	53941692	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtgtcacaggcccggttaGtaagtggtattaacaagtcc	11	9	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr2:53941692G>A	uc002rxg.1	-	7	944	c.809C>T	c.(808-810)ACT>ATT	p.T270I	ASB3_uc002rxh.1_Missense_Mutation_p.T197I|ASB3_uc002rxi.3_Missense_Mutation_p.T308I|ASB3_uc010yoo.1_Missense_Mutation_p.T187I	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	270	ANK 8.				intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GGCCCGGTTAGTAAGTGGTAT	0.393													A	53941692	A	A	53941692	3	1	116	1	0	0	0	0	1	0	0	0	1024	1029	36	3	763	3	ASB3	2	53941692	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08		53941692	189257681	10	7881											
DPP10	57628	broad.mit.edu	37	chr2	116593731	116593731	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatatatatttttcccccccAgggttatggtggctatattg	8	8	0	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr2:116593731A>G	uc002tla.1	+	22	2408	c.1951_splice	c.e22-2	p.G651_splice	DPP10_uc002tlb.1_Splice_Site_p.G601_splice|DPP10_uc002tlc.1_Splice_Site_p.G647_splice|DPP10_uc002tle.2_Splice_Site_p.G655_splice|DPP10_uc002tlf.1_Splice_Site_p.G644_splice	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long						proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TTTCCCCCCCAGGGTTATGGT	0.264													G	116593731	G	G	116593731	5	3	116	1	0	0	0	0	0	0	1	0	4727	202	7	4	2206	4	DPP10	2	116593731	Splice_Site	SNP	A	TCGA-12-0692-01A-01W-0348-08	62652039	116593731	126605642	11	7882											
RBM45	129831	broad.mit.edu	37	chr2	178990756	178990756	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taccttgtgtcaggaaaaaaTgtggggtatgccaagtatgc	12	6	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr2:178990756T>C	uc002ulv.2	+	9	1370	c.1278T>C	c.(1276-1278)AAT>AAC	p.N426N		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	428	RRM 3.				cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			CAGGAAAAAATGTGGGGTATG	0.348													C	178990756	C	C	178990756	2	2	116	1	0	0	0	0	0	0	0	1	13139	1461	51	4		4	RBM45	2	178990756	Silent	SNP	T	TCGA-12-0692-01A-01W-0348-08	62397025	178990756	64208617	12	7883											
ZDBF2	57683	broad.mit.edu	37	chr2	207169709	207169709	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agcagcccttggagtttgttCataaaattggggccagtgtg	13	7	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr2:207169709C>T	uc002vbp.2	+	5	707	c.457C>T	c.(457-459)CAT>TAT	p.H153Y		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	153							nucleic acid binding|zinc ion binding			ovary(3)	3						GGAGTTTGTTCATAAAATTGG	0.448													T	207169709	T	T	207169709	3	4	116	1	0	0	0	0	1	0	0	0	17596	826	29	3	467	3	ZDBF2	2	207169709	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	28178953	207169709	36029664	13	7884											
BARD1	580	broad.mit.edu	37	chr2	215609857	215609857	+	Frame_Shift_Del	DEL	C	-	-													cttcaaggtactttgaactgCatcaccaggaacaacaacat							TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr2:215609857delC	uc002veu.2	-	9	1972	c.1837delG	c.(1837-1839)GCAfs	p.A613fs	BARD1_uc010zjm.1_Frame_Shift_Del_p.A469fs	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	613	BRCT 1.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTTTGAACTGCATCACCAGGA	0.338									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				-	215609857	-	-	215609857	7	5	116	1	0	1	0	1	0	0	0	0	1312	710	25	0	508	0	BARD1	2	215609857	Frame_Shift_Del	DEL	C	TCGA-12-0692-01A-01W-0348-08	8440148	215609857	27589516	14	7885											
XIRP1	165904	broad.mit.edu	37	chr3	39225931	39225931	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ggatggagataaatgttgggGaggagggagaatctcggctg	19	3	1	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr3:39225931G>T	uc003cjk.1	-	2	5227	c.5006C>A	c.(5005-5007)TCC>TAC	p.S1669Y	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Missense_Mutation_p.S352Y	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1669							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AAATGTTGGGGAGGAGGGAGA	0.537													T	39225931	T	T	39225931	3	4	116	1	0	0	0	0	1	0	0	0	17426	1174	41	5	529	5	XIRP1	3	39225931	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08		39225931	158796499	15	7886											
KALRN	8997	broad.mit.edu	37	chr3	124053259	124053259	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtgttacatcaccagcgaCggctggagagcatctggcag	14	10	2	1	rs147539685		TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr3:124053259C>T	uc003ehg.2	+	9	1685	c.1558C>T	c.(1558-1560)CGG>TGG	p.R520W	KALRN_uc010hrv.1_Missense_Mutation_p.R520W|KALRN_uc003ehf.1_Missense_Mutation_p.R520W|KALRN_uc011bjy.1_Missense_Mutation_p.R520W	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	520					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TCACCAGCGACGGCTGGAGAG	0.622													T	124053259	T	T	124053259	3	4	116	1	0	0	0	0	1	0	0	0	7975	527	19	1	1592	1	KALRN	3	124053259	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	84827328	124053259	73969171	16	7887											
MSL2	55167	broad.mit.edu	37	chr3	135870091	135870091	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gaccctgtgacatttattacActggtgctggtactagcgtt	10	9	0	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr3:135870091A>T	uc003eqx.1	-	2	2365	c.1632T>A	c.(1630-1632)AGT>AGA	p.S544R	MSL2_uc011bmb.1_Missense_Mutation_p.S470R	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	544					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						CATTTATTACACTGGTGCTGG	0.468													T	135870091	T	T	135870091	3	4	116	1	0	0	0	0	1	0	0	0	9878	156	6	5	105	5	MSL2	3	135870091	Missense_Mutation	SNP	A	TCGA-12-0692-01A-01W-0348-08	11816832	135870091	62152339	17	7888											
AFM	173	broad.mit.edu	37	chr4	74361147	74361147	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccaggttgttaccgttacGcggtaggttccattgttgta	11	9	0	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr4:74361147G>A	uc003hhb.2	+	9	1220	c.1189G>A	c.(1189-1191)GCG>ACG	p.A397T		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	397	Albumin 2.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTACCGTTACGCGGTAGGTTC	0.378													A	74361147	A	A	74361147	3	1	116	1	0	0	0	0	1	0	0	0	361	1087	38	1	1223	1	AFM	4	74361147	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08		74361147	116793129	18	7889											
GRID2	2895	broad.mit.edu	37	chr4	94316790	94316790	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatcctgtcacaggtctgaaTgggtcactgactgacaagaa	10	9	3	4			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr4:94316790T>G	uc011cdt.1	+	9	1536	c.1278T>G	c.(1276-1278)AAT>AAG	p.N426K	GRID2_uc011cdu.1_Missense_Mutation_p.N331K	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	426	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CAGGTCTGAATGGGTCACTGA	0.433													G	94316790	G	G	94316790	3	3	116	1	0	0	0	0	1	0	0	0	6772	1461	51	5	1312	5	GRID2	4	94316790	Missense_Mutation	SNP	T	TCGA-12-0692-01A-01W-0348-08	19955643	94316790	96837486	19	7890											
ADAM29	11086	broad.mit.edu	37	chr4	175898213	175898213	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggatttttggtgcaggcGcaaatactgcaagtgagact	14	6	0	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr4:175898213G>A	uc003iuc.2	+	5	2207	c.1537G>A	c.(1537-1539)GCA>ACA	p.A513T	ADAM29_uc003iud.2_Missense_Mutation_p.A513T|ADAM29_uc010irr.2_Missense_Mutation_p.A513T|ADAM29_uc011cki.1_Missense_Mutation_p.A513T	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	513	Cys-rich.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding	p.A513T(1)		skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGGTGCAGGCGCAAATACTGC	0.418													A	175898213	A	A	175898213	3	1	116	1	0	0	0	0	1	0	0	0	247	1087	38	1	1539	1	ADAM29	4	175898213	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	81581423	175898213	15256063	20	7891											
TRIML1	339976	broad.mit.edu	37	chr4	189060967	189060967	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcagctccggtcccaggtGctgcagagcgaggatgagca	16	11	0	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr4:189060967G>A	uc003izm.1	+	1	370	c.255G>A	c.(253-255)GTG>GTA	p.V85V		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	85					multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GGTCCCAGGTGCTGCAGAGCG	0.652													A	189060967	A	A	189060967	2	1	116	1	0	0	0	0	0	0	0	1	16547	1306	46	3		3	TRIML1	4	189060967	Silent	SNP	G	TCGA-12-0692-01A-01W-0348-08	13162754	189060967	2093309	21	7892											
PCDHGB4	8641	broad.mit.edu	37	chr5	140769313	140769313	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcagcctggggctgcgcaCgggcgaagtgcgcacagcgc	16	14	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr5:140769313C>T	uc003lkc.1	+	1	1862	c.1862C>T	c.(1861-1863)ACG>ATG	p.T621M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.T621M	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	621	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCTGCGCACGGGCGAAGTG	0.692													T	140769313	T	T	140769313	3	4	116	1	0	0	0	0	1	0	0	0	11565	536	19	1	1864	1	PCDHGB4	5	140769313	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08		140769313	40145947	22	7893											
ATP10B	23120	broad.mit.edu	37	chr5	160061402	160061402	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctgcccatgatggtgcaaCgtcggaacaccatcttgttc	10	13	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr5:160061402C>T	uc003lym.1	-	12	2187	c.1340G>A	c.(1339-1341)CGT>CAT	p.R447H	ATP10B_uc003lyp.2_Missense_Mutation_p.R447H|ATP10B_uc011deg.1_Missense_Mutation_p.R491H|ATP10B_uc003lyn.2_Missense_Mutation_p.R5H|ATP10B_uc003lyo.2_Missense_Mutation_p.R419H	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	447	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GATGGTGCAACGTCGGAACAC	0.507													T	160061402	T	T	160061402	3	4	116	1	0	0	0	0	1	0	0	0	1117	536	19	1	3105	1	ATP10B	5	160061402	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	19292089	160061402	20853858	23	7894											
C6orf138	442213	broad.mit.edu	37	chr6	47976383	47976383	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagttacccatggcgaagaaCgggattcccagcagggtgga	14	9	0	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr6:47976383C>T	uc011dwm.1	-	2	928	c.843G>A	c.(841-843)CCG>CCA	p.P281P	C6orf138_uc011dwn.1_Silent_p.P45P|C6orf138_uc003ozf.2_Silent_p.P298P	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	298	Helical; (Potential).|SSD.					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						TGGCGAAGAACGGGATTCCCA	0.488													T	47976383	T	T	47976383	2	4	116	1	0	0	0	0	0	0	0	1	2332	523	19	1		1	C6orf138	6	47976383	Silent	SNP	C	TCGA-12-0692-01A-01W-0348-08		47976383	123138684	24	7895											
DEFB114	245928	broad.mit.edu	37	chr6	49928111	49928111	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagacagtctcttttacaaCgaccgtaacgtttggtgcaa	8	10	1	1	rs146020038		TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr6:49928111C>T	uc011dwp.1	-	2	104	c.104G>A	c.(103-105)CGT>CAT	p.R35H		NM_001037499	NP_001032588	Q30KQ6	DB114_HUMAN	beta-defensin 114 precursor	35					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					TCTTTTACAACGACCGTAACG	0.353													T	49928111	T	T	49928111	3	4	116	1	0	0	0	0	1	0	0	0	4403	536	19	1	108	1	DEFB114	6	49928111	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	1951728	49928111	121186956	25	7896											
CD109	135228	broad.mit.edu	37	chr6	74475666	74475666	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccattaggtgaaggtaactcGtgctgatggcaaccaactga	11	9	0	3			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr6:74475666G>A	uc003php.2	+	11	1546	c.1121G>A	c.(1120-1122)CGT>CAT	p.R374H	CD109_uc010kaz.2_Missense_Mutation_p.R374H|CD109_uc003phq.2_Missense_Mutation_p.R374H|CD109_uc010kba.2_Missense_Mutation_p.R297H	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	374						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						AAGGTAACTCGTGCTGATGGC	0.358													A	74475666	A	A	74475666	3	1	116	1	0	0	0	0	1	0	0	0	2963	1145	40	1	1163	1	CD109	6	74475666	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	24547555	74475666	96639401	26	7897											
TTLL2	83887	broad.mit.edu	37	chr6	167754816	167754816	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tctgtggtggagaaagctgtGagtgtgcgtcctgaagctgc	16	7	1	3			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr6:167754816G>C	uc003qvs.1	+	3	1516	c.1428G>C	c.(1426-1428)GTG>GTC	p.V476V	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	476					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		AGAAAGCTGTGAGTGTGCGTC	0.512													C	167754816	C	C	167754816	2	2	116	1	0	0	0	0	0	0	0	1	16724	1277	45	5		5	TTLL2	6	167754816	Silent	SNP	G	TCGA-12-0692-01A-01W-0348-08	93279150	167754816	3360251	27	7898											
PRKAR1B	5575	broad.mit.edu	37	chr7	618975	618975	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaactggacgggctccagcGcatccgccacggtcagacgc	12	16	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr7:618975G>A	uc003siu.1	-	10	915	c.809C>T	c.(808-810)GCG>GTG	p.A270V	PRKAR1B_uc003siv.2_Missense_Mutation_p.A270V|PRKAR1B_uc003siw.1_Missense_Mutation_p.A270V|PRKAR1B_uc003six.1_RNA	NM_002735	NP_002726	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type	270	cAMP 2.			A -> R (in Ref. 1; AAC37564).	activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		GGGCTCCAGCGCATCCGCCAC	0.612													A	618975	A	A	618975	3	1	116	1	0	0	0	0	1	0	0	0	12504	1087	38	1	348	1	PRKAR1B	7	618975	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08		618975	158519688	28	7899											
NUPL2	11097	broad.mit.edu	37	chr7	23239787	23239787	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgttgttgttgtttgtagGctttccagtcaataacagca	10	6	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr7:23239787G>A	uc003svu.2	+	7	954	c.695G>A	c.(694-696)GGC>GAC	p.G232D	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_Missense_Mutation_p.G109D|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_Missense_Mutation_p.G109D|NUPL2_uc011jyx.1_Missense_Mutation_p.G4D	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	232					carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						ttgttTGTAGGCTTTCCAGTC	0.318													A	23239787	A	A	23239787	3	1	116	1	0	0	0	0	1	0	0	0	10775	1217	42	3	721	3	NUPL2	7	23239787	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	22620812	23239787	135898876	29	7900											
STK31	56164	broad.mit.edu	37	chr7	23825130	23825130	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttacaatgagcttggaaCgagatcttcttgatgctgag	10	8	2	4			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr7:23825130C>T	uc003sws.3	+	18	2249	c.2182C>T	c.(2182-2184)CGA>TGA	p.R728*	STK31_uc003swt.3_Nonsense_Mutation_p.R705*|STK31_uc011jze.1_Nonsense_Mutation_p.R728*|STK31_uc010kuq.2_Nonsense_Mutation_p.R705*|STK31_uc003swv.1_5'Flank	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	728	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						GAGCTTGGAACGAGATCTTCT	0.403													T	23825130	T	T	23825130	4	4	116	1	0	0	0	0	0	1	0	0	15295	528	19	1	2252	1	STK31	7	23825130	Nonsense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	585343	23825130	135313533	30	7901											
WNT2	7472	broad.mit.edu	37	chr7	116960726	116960726	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctgctgtccactcggccaCgccctggctaatggcacgca	10	16	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr7:116960726C>T	uc003viz.2	-	2	505	c.205G>A	c.(205-207)GTG>ATG	p.V69M	WNT2_uc003vja.2_Translation_Start_Site	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	69					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACTCGGCCACGCCCTGGCTA	0.602													T	116960726	T	T	116960726	3	4	116	1	0	0	0	0	1	0	0	0	17383	536	19	1	893	1	WNT2	7	116960726	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	93135596	116960726	42177937	31	7902											
MGAM	8972	broad.mit.edu	37	chr7	141759386	141759386	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaaggctgatgggatgcggGtcatcctcattctggttagt	14	7	3	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr7:141759386G>A	uc003vwy.2	+	32	3988	c.3934G>A	c.(3934-3936)GTC>ATC	p.V1312I		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1312	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TGGGATGCGGGTCATCCTCAT	0.507													A	141759386	A	A	141759386	3	1	116	1	0	0	0	0	1	0	0	0	9541	1261	44	3	4056	3	MGAM	7	141759386	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	24798660	141759386	17379277	32	7903											
STC1	6781	broad.mit.edu	37	chr8	23709003	23709003	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagaccttggaggtgaccccGttggcgatgcattttaagct	12	9	0	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr8:23709003G>A	uc003xdw.1	-	3	587	c.303C>T	c.(301-303)AAC>AAT	p.N101N		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor	101					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		AGGTGACCCCGTTGGCGATGC	0.517													A	23709003	A	A	23709003	2	1	116	1	0	0	0	0	0	0	0	1	15274	1136	40	1		1	STC1	8	23709003	Silent	SNP	G	TCGA-12-0692-01A-01W-0348-08		23709003	122655019	33	7904											
UNC5D	137970	broad.mit.edu	37	chr8	35407016	35407016	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	acgtctctgaagagactctgGacgagagctcaggtaggagc	14	9	3	3			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr8:35407016G>C	uc003xjr.1	+	2	638	c.310G>C	c.(310-312)GAC>CAC	p.D104H	UNC5D_uc003xjs.1_Missense_Mutation_p.D99H	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	104	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AGAGACTCTGGACGAGAGCTC	0.522													C	35407016	C	C	35407016	3	2	116	1	0	0	0	0	1	0	0	0	16992	1174	41	5	316	5	UNC5D	8	35407016	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	11698013	35407016	110957006	34	7905											
PTDSS1	9791	broad.mit.edu	37	chr8	97285591	97285591	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgttattttcttctttcttAtcatcagtgtgttagctttc	5	8	5	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr8:97285591A>G	uc003yht.1	+	2	346	c.244A>G	c.(244-246)ATC>GTC	p.I82V	PTDSS1_uc003yhu.1_5'UTR	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	82	Helical; (Potential).				phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	CTTCTTTCTTATCATCAGTGT	0.373													G	97285591	G	G	97285591	3	3	116	1	0	0	0	0	1	0	0	0	12736	449	16	4	250	4	PTDSS1	8	97285591	Missense_Mutation	SNP	A	TCGA-12-0692-01A-01W-0348-08	61878575	97285591	49078431	35	7906											
TEK	7010	broad.mit.edu	37	chr9	27217701	27217701	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagggaaggctcccagtgCgctggatggccatcgagtca	14	12	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr9:27217701C>T	uc003zqi.3	+	19	3449	c.3007C>T	c.(3007-3009)CGC>TGC	p.R1003C	TEK_uc011lno.1_Missense_Mutation_p.R960C|TEK_uc011lnp.1_Missense_Mutation_p.R855C	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	1003	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GCTCCCAGTGCGCTGGATGGC	0.483													T	27217701	T	T	27217701	3	4	116	1	0	0	0	0	1	0	0	0	15748	768	27	1	3081	1	TEK	9	27217701	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08		27217701	113995730	36	7907											
ZNF618	114991	broad.mit.edu	37	chr9	116811355	116811355	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgcggacattcgcgacagCggtgaccttgtgcaccactg	14	12	0	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr9:116811355C>T	uc004bid.2	+	15	1872	c.1773C>T	c.(1771-1773)AGC>AGT	p.S591S	ZNF618_uc004bic.2_Silent_p.S498S|ZNF618_uc011lxi.1_Silent_p.S558S|ZNF618_uc011lxj.1_Silent_p.S559S|ZNF618_uc010mvb.2_Silent_p.S181S	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCGCGACAGCGGTGACCTTG	0.592													T	116811355	T	T	116811355	2	4	116	1	0	0	0	0	0	0	0	1	18039	767	27	1		1	ZNF618	9	116811355	Silent	SNP	C	TCGA-12-0692-01A-01W-0348-08	89593654	116811355	24402076	37	7908											
RABGAP1	23637	broad.mit.edu	37	chr9	125748579	125748579	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acttacttaggctgtgcctcGgtaaatgctcccaggagtga	11	10	0	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr9:125748579G>T	uc011lzh.1	+	4	605	c.471G>T	c.(469-471)TCG>TCT	p.S157S	RABGAP1_uc004bnl.3_RNA|RABGAP1_uc004bnm.1_Silent_p.S157S	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	157	PID.				cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						GCTGTGCCTCGGTAAATGCTC	0.453													T	125748579	T	T	125748579	2	4	116	1	0	0	0	0	0	0	0	1	12964	1103	39	5		5	RABGAP1	9	125748579	Silent	SNP	G	TCGA-12-0692-01A-01W-0348-08	8937224	125748579	15464852	38	7909											
CAMSAP1	157922	broad.mit.edu	37	chr9	138714648	138714648	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctagacacgatgctcctcGgtctcccttccccccgttca	6	19	2	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr9:138714648G>A	uc004cgr.3	-	11	1859	c.1859C>T	c.(1858-1860)CCG>CTG	p.P620L	CAMSAP1_uc004cgq.3_Missense_Mutation_p.P510L|CAMSAP1_uc010nbg.2_Missense_Mutation_p.P342L	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	620						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GATGCTCCTCGGTCTCCCTTC	0.542													A	138714648	A	A	138714648	3	1	116	1	0	0	0	0	1	0	0	0	2611	1116	39	2	2977	2	CAMSAP1	9	138714648	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	12966069	138714648	2498783	39	7910											
CCAR1	55749	broad.mit.edu	37	chr10	70496806	70496806	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cagcagctgcattacaacagGtaaatctttaatatgtctta	6	8	2	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr10:70496806G>C	uc001joo.2	+	3	365	c.246_splice	c.e3+1	p.Q82_splice	CCAR1_uc001jol.1_Splice_Site|CCAR1_uc001jom.1_Splice_Site|CCAR1_uc009xpx.1_Splice_Site_p.Q82_splice|CCAR1_uc001jon.1_Splice_Site_p.A72_splice|CCAR1_uc010qiz.1_Splice_Site_p.Q82_splice|CCAR1_uc010qja.1_Splice_Site_p.Q82_splice|CCAR1_uc010qjb.1_Splice_Site	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1						apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						ATTACAACAGGTAAATCTTTA	0.393													C	70496806	C	C	70496806	5	2	116	1	0	0	0	0	0	0	1	0	2730	1275	44	5	253	5	CCAR1	10	70496806	Splice_Site	SNP	G	TCGA-12-0692-01A-01W-0348-08		70496806	65037941	40	7911											
CRTAC1	55118	broad.mit.edu	37	chr10	99664517	99664517	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgatgtccactttgccatcaCggttgaagtcagccagggcg	12	12	2	1	rs149424033		TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr10:99664517C>T	uc001kou.1	-	7	1261	c.905G>A	c.(904-906)CGT>CAT	p.R302H	CRTAC1_uc001kov.2_Missense_Mutation_p.R291H|CRTAC1_uc001kot.1_Missense_Mutation_p.R92H	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	302	FG-GAP 3; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		TTTGCCATCACGGTTGAAGTC	0.617													T	99664517	T	T	99664517	3	4	116	1	0	0	0	0	1	0	0	0	3896	536	19	1	1116	1	CRTAC1	10	99664517	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	29167711	99664517	35870230	41	7912											
RHOG	391	broad.mit.edu	37	chr11	3849147	3849147	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cagatgacgaaaacgttggtCtgagggtaggagagtgtacg	16	5	1	4			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr11:3849147C>T	uc001lyu.2	-	2	380	c.222G>A	c.(220-222)CAG>CAA	p.Q74Q		NM_001665	NP_001656	P84095	RHOG_HUMAN	ras homolog gene family, member G precursor	74					actin cytoskeleton organization|activation of Rac GTPase activity|axon guidance|cell chemotaxis|platelet activation|positive regulation of cell proliferation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of transcription, DNA-dependent|Rac protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0349)|LUSC - Lung squamous cell carcinoma(625;0.194)		AAACGTTGGTCTGAGGGTAGG	0.602													T	3849147	T	T	3849147	2	4	116	1	0	0	0	0	0	0	0	1	13339	912	32	3		3	RHOG	11	3849147	Silent	SNP	C	TCGA-12-0692-01A-01W-0348-08		3849147	131157369	42	7913											
OR51F1	256892	broad.mit.edu	37	chr11	4790709	4790709	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acgtgtaatcatcagaagacCcatttgaatgattctggaat	8	7	3	4			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr11:4790709C>A	uc010qyl.1	-	1	439	c.439G>T	c.(439-441)GGT>TGT	p.G147C		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	147						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		ATCAGAAGACCCATTTGAATG	0.433													A	4790709	A	A	4790709	3	1	116	1	0	0	0	0	1	0	0	0	11096	623	22	5	502	5	OR51F1	11	4790709	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	941562	4790709	130215807	43	7914											
SAPS3	55291	broad.mit.edu	37	chr11	68315674	68315674	+	Splice_Site	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caggcaagatgtgctgaatgTgagtagaattctgacctgct	12	7	1	5			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr11:68315674T>G	uc001onw.2	+	5	819	c.552_splice	c.e5+2	p.N184_splice	SAPS3_uc010rqb.1_Splice_Site_p.N93_splice|SAPS3_uc001onv.2_Splice_Site_p.N184_splice|SAPS3_uc001ony.3_Splice_Site_p.N184_splice|SAPS3_uc001onx.2_Splice_Site_p.N184_splice|SAPS3_uc009ysh.2_Splice_Site_p.N184_splice|SAPS3_uc001onu.2_Splice_Site_p.N184_splice|SAPS3_uc010rqc.1_Splice_Site_p.N93_splice	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6						regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			GTGCTGAATGTGAGTAGAATT	0.507													G	68315674	G	G	68315674	5	3	116	1	0	0	0	0	0	0	1	0	13838	1710	59	5	564	5	SAPS3	11	68315674	Splice_Site	SNP	T	TCGA-12-0692-01A-01W-0348-08	63524965	68315674	66690842	44	7915											
PCF11	51585	broad.mit.edu	37	chr11	82880169	82880169	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggggctgcgattaggtttgAtggacctcatggtcagccag	15	8	2	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr11:82880169A>T	uc001ozx.3	+	8	3137	c.2792A>T	c.(2791-2793)GAT>GTT	p.D931V	PCF11_uc010rsu.1_Missense_Mutation_p.D1062V	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	931	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ATTAGGTTTGATGGACCTCAT	0.537													T	82880169	T	T	82880169	3	4	116	1	0	0	0	0	1	0	0	0	11573	333	12	5	2822	5	PCF11	11	82880169	Missense_Mutation	SNP	A	TCGA-12-0692-01A-01W-0348-08	14564495	82880169	52126347	45	7916											
CNTN5	53942	broad.mit.edu	37	chr11	100211381	100211382	+	Splice_Site	INS	-	GT	GT													tgcaaccaccaagaaatcccINSgtaagtgacctgggcttttt							TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr11:100211381_100211382insGT	uc001pga.2	+	22	3256	c.2917_splice	c.e22+1	p.P973_splice	CNTN5_uc001pgb.2_Splice_Site_p.P899_splice|CNTN5_uc010ruk.1_Splice_Site_p.P244_splice	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long						cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CAAGAAATCCCGTAAGTGACCT	0.441													GT	100211382	GT	GT	100211381	8	5	116	1	0	1	1	0	0	0	1	0	3644	666	23	0	2995	0	CNTN5	11	100211381	Splice_Site	INS	-	TCGA-12-0692-01A-01W-0348-08	17331212	100211381	34795135	46	7917											
ANO2	57101	broad.mit.edu	37	chr12	5908716	5908716	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttatagaacactccatagcGcgcccattcttgatatagca	6	12	1	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr12:5908716G>A	uc001qnm.2	-	10	1072	c.1000C>T	c.(1000-1002)CGC>TGC	p.R334C		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	339	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						ACTCCATAGCGCGCCCATTCT	0.423													A	5908716	A	A	5908716	3	1	116	1	0	0	0	0	1	0	0	0	697	1087	38	1	2064	1	ANO2	12	5908716	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08		5908716	127943179	47	7918											
ABCC9	10060	broad.mit.edu	37	chr12	21965043	21965043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgaaagtctagaacgtagtGtgtgcagtggtaatttggaa	13	3	1	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr12:21965043G>T	uc001rfi.1	-	34	4171	c.4151C>A	c.(4150-4152)ACA>AAA	p.T1384K	ABCC9_uc001rfh.2_Missense_Mutation_p.T1384K|ABCC9_uc001rfj.1_Missense_Mutation_p.T1348K	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1384	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGAACGTAGTGTGTGCAGTGG	0.358													T	21965043	T	T	21965043	3	4	116	1	0	0	0	0	1	0	0	0	59	1377	48	5	660	5	ABCC9	12	21965043	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	16056327	21965043	111886852	48	7919											
PIWIL1	9271	broad.mit.edu	37	chr12	130847606	130847606	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcgtgtaccgcgatggcgtAggagacggccagctgaaaac	14	10	0	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr12:130847606A>G	uc001uik.2	+	18	2202	c.2112A>G	c.(2110-2112)GTA>GTG	p.V704V	PIWIL1_uc001uij.1_Silent_p.V704V	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	704	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GCGATGGCGTAGGAGACGGCC	0.478													G	130847606	G	G	130847606	2	3	116	1	0	0	0	0	0	0	0	1	11957	407	15	4		4	PIWIL1	12	130847606	Silent	SNP	A	TCGA-12-0692-01A-01W-0348-08	108882563	130847606	3004289	49	7920											
FLT3	2322	broad.mit.edu	37	chr13	28597589	28597589	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctcttcttccagcctTttttggttttcatattcaat	3	12	4	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr13:28597589T>A	uc001urw.2	-	19	2398	c.2316A>T	c.(2314-2316)AAA>AAT	p.K772N	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.K772N	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	772	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTTCCAGCCTTTTTTGGTTTT	0.348			Mis|O		AML|ALL								A	28597589	A	A	28597589	3	1	116	1	0	0	0	0	1	0	0	0	5942	1838	64	5	689	5	FLT3	13	28597589	Missense_Mutation	SNP	T	TCGA-12-0692-01A-01W-0348-08		28597589	86572289	50	7921											
FAM70B	348013	broad.mit.edu	37	chr13	114507939	114507939	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccagcagatcctggcctacGcaggcttccgcctgacgccc	10	19	0	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr13:114507939G>A	uc001vuh.2	+	8	778	c.751G>A	c.(751-753)GCA>ACA	p.A251T		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	251						integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			CCTGGCCTACGCAGGCTTCCG	0.677													A	114507939	A	A	114507939	3	1	116	1	0	0	0	0	1	0	0	0	5606	1087	38	1	781	1	FAM70B	13	114507939	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	85910350	114507939	661939	51	7922											
EDDM3B	64184	broad.mit.edu	37	chr14	21238424	21238424	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aattcatgaaacagcactacTtaagtccaagtcgagaattc	6	9	1	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr14:21238424T>G	uc001vyd.2	+	2	213	c.115T>G	c.(115-117)TTA>GTA	p.L39V		NM_022360	NP_071755	P56851	EP3B_HUMAN	human epididymis-specific 3 beta precursor	39					spermatid development	extracellular region				ovary(1)	1						ACAGCACTACTTAAGTCCAAG	0.413													G	21238424	G	G	21238424	3	3	116	1	0	0	0	0	1	0	0	0	4910	1606	56	5	117	5	EDDM3B	14	21238424	Missense_Mutation	SNP	T	TCGA-12-0692-01A-01W-0348-08		21238424	86111116	52	7923											
CTSG	1511	broad.mit.edu	37	chr14	25042969	25042969	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gacgactttccataggagacGatgccgtgggccacattgtt	12	10	0	1	rs147260851	byFrequency	TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr14:25042969G>A	uc001wpq.2	-	5	679	c.642C>T	c.(640-642)ATC>ATT	p.I214I		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	214	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		CATAGGAGACGATGCCGTGGG	0.557													A	25042969	A	A	25042969	2	1	116	1	0	0	0	0	0	0	0	1	4035	1048	37	2		2	CTSG	14	25042969	Silent	SNP	G	TCGA-12-0692-01A-01W-0348-08	3804545	25042969	82306571	53	7924											
CDKL1	8814	broad.mit.edu	37	chr14	50802891	50802891	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgagcgtttcacagccccAgaagcaagcaggcctccctc	10	15	1	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr14:50802891A>G	uc010anu.1	-	20	2802	c.2802T>C	c.(2800-2802)TCT>TCC	p.S934S	CDKL1_uc001wxz.2_Intron	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					TCACAGCCCCAGAAGCAAGCA	0.567													G	50802891	G	G	50802891	2	3	116	1	0	0	0	0	0	0	0	1	3153	203	7	4		4	CDKL1	14	50802891	Silent	SNP	A	TCGA-12-0692-01A-01W-0348-08	25759922	50802891	56546649	54	7925											
FAM181A	90050	broad.mit.edu	37	chr14	94394937	94394937	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggagaaggtgctgaggaaCccctacagggaggaatgtct	15	7	1	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr14:94394937C>T	uc001ybz.1	+	3	799	c.492C>T	c.(490-492)AGC>AGT	p.S164S	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Silent_p.N102N|FAM181A_uc001yca.1_Silent_p.N102N	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	164				N -> S (in Ref. 2; BAC04151).							0						TGCTGAGGAACCCCTACAGGG	0.637													T	94394937	T	T	94394937	2	4	116	1	0	0	0	0	0	0	0	1	5508	506	18	3		3	FAM181A	14	94394937	Silent	SNP	C	TCGA-12-0692-01A-01W-0348-08	43592046	94394937	12954603	55	7926											
SLC12A6	9990	broad.mit.edu	37	chr15	34528395	34528395	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagtttcggtctttcaccaaTtgtgcctgaggaagaaggtc	12	8	2	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr15:34528395T>C	uc001zhw.2	-	23	3212	c.3048A>G	c.(3046-3048)CAA>CAG	p.Q1016Q	SLC12A6_uc001zhv.2_Silent_p.Q965Q|SLC12A6_uc001zhx.2_Silent_p.Q1001Q|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Silent_p.Q957Q|SLC12A6_uc001zib.2_Silent_p.Q1007Q|SLC12A6_uc001zic.2_Silent_p.Q1016Q|SLC12A6_uc010bau.2_Silent_p.Q1016Q|SLC12A6_uc001zid.2_Silent_p.Q957Q|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Silent_p.Q828Q	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	1016	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CTTTCACCAATTGTGCCTGAG	0.413													C	34528395	C	C	34528395	2	2	116	1	0	0	0	0	0	0	0	1	14387	1490	52	4		4	SLC12A6	15	34528395	Silent	SNP	T	TCGA-12-0692-01A-01W-0348-08		34528395	68002997	56	7927											
LMAN1L	79748	broad.mit.edu	37	chr15	75116023	75116023	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggagcttcggggcccggcGgtgaggggaaagtagtgggc	22	7	0	1	rs147808783	byFrequency	TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr15:75116023G>A	uc002ayt.1	+	12	1325	c.1323G>A	c.(1321-1323)GCG>GCA	p.A441A	LMAN1L_uc010bke.1_Silent_p.A429A|CPLX3_uc002ayu.1_5'Flank	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	441	Lumenal (Potential).					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						GGGGCCCGGCGGTGAGGGGAA	0.622													A	75116023	A	A	75116023	2	1	116	1	0	0	0	0	0	0	0	1	8837	1130	39	2		2	LMAN1L	15	75116023	Silent	SNP	G	TCGA-12-0692-01A-01W-0348-08	40587628	75116023	27415369	57	7928											
DNAH3	55567	broad.mit.edu	37	chr16	20974846	20974846	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gagttgctcctcatggggccAggccgagtcatagatcagct	13	11	3	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr16:20974846A>T	uc010vbe.1	-	53	10360	c.10360T>A	c.(10360-10362)TGG>AGG	p.W3454R	DNAH3_uc010vbd.1_Missense_Mutation_p.W889R	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3454					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCATGGGGCCAGGCCGAGTCA	0.532													T	20974846	T	T	20974846	3	4	116	1	0	0	0	0	1	0	0	0	4603	188	7	5	2029	5	DNAH3	16	20974846	Missense_Mutation	SNP	A	TCGA-12-0692-01A-01W-0348-08		20974846	69379907	58	7929											
SRCAP	10847	broad.mit.edu	37	chr16	30748842	30748842	+	Missense_Mutation	SNP	G	C	C													tccttcacagattcctccttGttcttctcctgcctgcaccc							TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr16:30748842G>C	uc002dze.1	+	34	7866	c.7481G>C	c.(7480-7482)TGT>TCT	p.C2494S	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.C2289S	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2494	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			attcctccttgttcttctcct	0.149													C	30748842	C	C	30748842	3	2	116	1	0	0	0	0	1	0	0	0	15134	1377	48	5	7607	5	SRCAP	16	30748842	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	9773996	30748842	59605911	59	7930	10	2									
SRCAP	10847	broad.mit.edu	37	chr16	30748845	30748845	+	Missense_Mutation	SNP	C	G	G													ttcacagattcctccttgttCttctcctgcctgcacccctc							TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr16:30748845C>G	uc002dze.1	+	34	7869	c.7484C>G	c.(7483-7485)TCT>TGT	p.S2495C	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.S2290C	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2495	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			cctccttgttcttctcctgcc	0.154													G	30748845	G	G	30748845	3	3	116	1	0	0	0	0	1	0	0	0	15134	913	32	5	7610	5	SRCAP	16	30748845	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	3	30748845	59605908	60	7931	10	2									
ITGAD	3681	broad.mit.edu	37	chr16	31429674	31429674	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caaggccaccctgggagacaGgatgcttatgagggccagtg	15	10	0	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr16:31429674G>T	uc002ebv.1	+	22	2718	c.2669G>T	c.(2668-2670)AGG>ATG	p.R890M	ITGAD_uc010cap.1_Missense_Mutation_p.R891M	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	890	Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CTGGGAGACAGGATGCTTATG	0.572													T	31429674	T	T	31429674	3	4	116	1	0	0	0	0	1	0	0	0	7884	1000	35	5	2755	5	ITGAD	16	31429674	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	680829	31429674	58925079	61	7932											
PLA2G15	23659	broad.mit.edu	37	chr16	68288909	68288909	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgggaagaccttctcactGgagttcctggaccccagcaa	10	12	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr16:68288909G>A	uc002evr.2	+	3	455	c.372G>A	c.(370-372)CTG>CTA	p.L124L	PLA2G15_uc010vld.1_Silent_p.L124L|PLA2G15_uc010vle.1_Nonsense_Mutation_p.W72*|PLA2G15_uc010vlf.1_Intron|PLA2G15_uc002evs.2_5'UTR	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	124					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1						CCTTCTCACTGGAGTTCCTGG	0.572													A	68288909	A	A	68288909	2	1	116	1	0	0	0	0	0	0	0	1	11992	1335	47	3		3	PLA2G15	16	68288909	Silent	SNP	G	TCGA-12-0692-01A-01W-0348-08	36859235	68288909	22065844	62	7933											
ITGAE	3682	broad.mit.edu	37	chr17	3651273	3651273	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acataaacggacattcacgaCgccgttgaagccgatgggca	11	11	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr17:3651273C>T	uc002fwo.3	-	17	2197	c.2098G>A	c.(2098-2100)GTC>ATC	p.V700I		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	700	Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		ACATTCACGACGCCGTTGAAG	0.542													T	3651273	T	T	3651273	3	4	116	1	0	0	0	0	1	0	0	0	7885	536	19	1	1501	1	ITGAE	17	3651273	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08		3651273	77543937	63	7934											
LGALS9B	284194	broad.mit.edu	37	chr17	20363749	20363749	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cttggatagtcccagaaaagGggacggcctgcagggagaag	16	8	0	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr17:20363749G>C	uc002gxa.1	-	2	112	c.47C>G	c.(46-48)CCC>CGC	p.P16R	LGALS9B_uc002gwz.1_Missense_Mutation_p.P16R|LGALS9B_uc010vzh.1_Intron	NM_001042685	NP_001036150	Q3B8N2	LEG9B_HUMAN	galectin-9 like	16							sugar binding			skin(1)	1						CCCAGAAAAGGGGACGGCCTG	0.592													C	20363749	C	C	20363749	3	2	116	1	0	0	0	0	1	0	0	0	8749	1232	43	5	1060	5	LGALS9B	17	20363749	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	16712476	20363749	60831461	64	7935											
IGF2BP1	10642	broad.mit.edu	37	chr17	47115627	47115627	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacagggacctgagaatgggCgccgagggggctttggctct	17	10	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr17:47115627C>T	uc002iom.2	+	6	833	c.499C>T	c.(499-501)CGC>TGC	p.R167C	IGF2BP1_uc010dbj.2_Intron	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	167					CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						TGAGAATGGGCGCCGAGGGGG	0.637													T	47115627	T	T	47115627	3	4	116	1	0	0	0	0	1	0	0	0	7573	768	27	1	521	1	IGF2BP1	17	47115627	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	26751878	47115627	34079583	65	7936											
TNFSF14	8740	broad.mit.edu	37	chr19	6669978	6669978	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acccagacccacccgggccaCactgcacgactgtctccggt	9	19	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr19:6669978C>A	uc002mfk.1	-	2	485	c.103G>T	c.(103-105)GTG>TTG	p.V35L	TNFSF14_uc002mfj.1_Missense_Mutation_p.V35L	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	35	Cytoplasmic (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						ACCCGGGCCACACTGCACGAC	0.632													A	6669978	A	A	6669978	3	1	116	1	0	0	0	0	1	0	0	0	16304	478	17	5	635	5	TNFSF14	19	6669978	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08		6669978	52459005	66	7937											
ZNF560	147741	broad.mit.edu	37	chr19	9579010	9579010	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctccattttggtttcttgCctgttaacacaggaatgaac	7	10	2	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr19:9579010C>T	uc002mlp.1	-	10	823	c.613G>A	c.(613-615)GCA>ACA	p.A205T	ZNF560_uc010dwr.1_Missense_Mutation_p.A99T	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TGGTTTCTTGCCTGTTAACAC	0.338													T	9579010	T	T	9579010	3	4	116	1	0	0	0	0	1	0	0	0	17988	753	26	3	1763	3	ZNF560	19	9579010	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	2909032	9579010	49549973	67	7938											
OR1I1	126370	broad.mit.edu	37	chr19	15198267	15198267	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccattgtccacccacagCgttacttggttctcatgtgc	9	13	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr19:15198267C>T	uc010xoe.1	+	1	391	c.391C>T	c.(391-393)CGT>TGT	p.R131C		NM_001004713	NP_001004713	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3						CCACCCACAGCGTTACTTGGT	0.567													T	15198267	T	T	15198267	3	4	116	1	0	0	0	0	1	0	0	0	10958	768	27	1	393	1	OR1I1	19	15198267	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	5619257	15198267	43930716	68	7939											
NLRP4	147945	broad.mit.edu	37	chr19	56388509	56388509	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcgggctctgacgcatacGgattgccgcttagagattct	12	10	2	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr19:56388509G>A	uc002qmd.3	+	8	3095	c.2673G>A	c.(2671-2673)ACG>ACA	p.T891T	NLRP4_uc002qmf.2_Silent_p.T816T|NLRP4_uc010etf.2_Silent_p.T666T	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	891							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TGACGCATACGGATTGCCGCT	0.478													A	56388509	A	A	56388509	2	1	116	1	0	0	0	0	0	0	0	1	10479	1103	39	2		2	NLRP4	19	56388509	Silent	SNP	G	TCGA-12-0692-01A-01W-0348-08	41190242	56388509	2740474	69	7940											
STK35	140901	broad.mit.edu	37	chr20	2097899	2097899	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttgcacatcccccaaaaaCgcaggacttccatgtctgag	8	13	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr20:2097899C>T	uc010gak.2	+	3	1480	c.1480C>T	c.(1480-1482)CGC>TGC	p.R494C	STK35_uc010zpu.1_Intron|STK35_uc002wfw.3_Missense_Mutation_p.R361C	NM_080836	NP_543026	Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	494	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CCCCCAAAAACGCAGGACTTC	0.512													T	2097899	T	T	2097899	3	4	116	1	0	0	0	0	1	0	0	0	15300	536	19	1	1490	1	STK35	20	2097899	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08		2097899	60927621	70	7941											
TRMT6	51605	broad.mit.edu	37	chr20	5925484	5925485	+	Frame_Shift_Del	DEL	TA	-	-													cccttgtccttcaaagctttTatgtcatcttgagtaagttt							TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr20:5925484_5925485delTA	uc002wmh.1	-	3	454_455	c.332_333delTA	c.(331-333)ATAfs	p.I111fs	TRMT6_uc010zra.1_Intron|TRMT6_uc010gbn.1_Intron|TRMT6_uc010gbo.1_RNA	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	111					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1						TCAAAGCTTTTATGTCATCTTG	0.342													-	5925485	-	-	5925484	7	5	116	1	0	1	0	1	0	0	0	0	16565	1744	61	0	1196	0	TRMT6	20	5925484	Frame_Shift_Del	DEL	TA	TCGA-12-0692-01A-01W-0348-08	3827585	5925484	57100036	71	7942											
CHD6	84181	broad.mit.edu	37	chr20	40043955	40043955	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggcttccattgacaatctgTccagtcacaggatggatcag	10	10	3	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr20:40043955T>C	uc002xka.1	-	34	6988	c.6810A>G	c.(6808-6810)GGA>GGG	p.G2270G	CHD6_uc002xjz.1_5'Flank	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2270					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TGACAATCTGTCCAGTCACAG	0.537													C	40043955	C	C	40043955	2	2	116	1	0	0	0	0	0	0	0	1	3329	1654	58	4		4	CHD6	20	40043955	Silent	SNP	T	TCGA-12-0692-01A-01W-0348-08	34118471	40043955	22981565	72	7943											
SYS1	90196	broad.mit.edu	37	chr20	43995683	43995683	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	attgcactcatggctgtcatCggggagtacctgtgcatgcg	13	10	2	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr20:43995683C>T	uc002xnv.2	+	4	657	c.399C>T	c.(397-399)ATC>ATT	p.I133I	SYS1_uc010gha.2_RNA|SYS1_uc002xnw.1_Intron|SYS1-DBNDD2_uc002xnx.2_Intron	NM_033542	NP_291020	Q8N2H4	SYS1_HUMAN	SYS1 Golgi-localized integral membrane protein	133	Helical; (Potential).				protein transport	Golgi membrane|integral to membrane				skin(1)	1		Myeloproliferative disorder(115;0.0122)				TGGCTGTCATCGGGGAGTACC	0.577													T	43995683	T	T	43995683	2	4	116	1	0	0	0	0	0	0	0	1	15461	874	31	2		2	SYS1	20	43995683	Silent	SNP	C	TCGA-12-0692-01A-01W-0348-08	3951728	43995683	19029837	73	7944											
TSHZ2	128553	broad.mit.edu	37	chr20	51870964	51870964	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtcaccccggctaagaaaCgcgtttttgatgtcaatcgg	11	10	2	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr20:51870964C>T	uc002xwo.2	+	2	1923	c.967C>T	c.(967-969)CGC>TGC	p.R323C		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	323					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GGCTAAGAAACGCGTTTTTGA	0.453													T	51870964	T	T	51870964	3	4	116	1	0	0	0	0	1	0	0	0	16621	536	19	1	973	1	TSHZ2	20	51870964	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	7875281	51870964	11154556	74	7945											
CSF2RB	1439	broad.mit.edu	37	chr22	37326752	37326752	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtgctgagggaggggctcGgcagcctccacaccaggcac	15	14	0	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr22:37326752G>A	uc003aqa.3	+	8	1109	c.892G>A	c.(892-894)GGC>AGC	p.G298S	CSF2RB_uc003aqc.3_Missense_Mutation_p.G304S	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	298	Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	GGAGGGGCTCGGCAGCCTCCA	0.647													A	37326752	A	A	37326752	3	1	116	1	0	0	0	0	1	0	0	0	3935	1116	39	2	918	2	CSF2RB	22	37326752	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08		37326752	13977814	75	7946											
ENTHD1	150350	broad.mit.edu	37	chr22	40283548	40283548	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagggatttatacacgtggcGccagttcttcccatggtcat	10	10	2	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr22:40283548G>A	uc003ayg.2	-	2	456	c.205C>T	c.(205-207)CGC>TGC	p.R69C		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	69	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					TACACGTGGCGCCAGTTCTTC	0.403													A	40283548	A	A	40283548	3	1	116	1	0	0	0	0	1	0	0	0	5137	1087	38	1	1642	1	ENTHD1	22	40283548	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	2956796	40283548	11021018	76	7947											
CYP2D6	1565	broad.mit.edu	37	chr22	42524294	42524294	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaggaaagccttttggaagCgtaggaccttgccagccagc	12	11	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chr22:42524294C>T	uc003bce.2	-	5	815	c.725G>A	c.(724-726)CGC>CAC	p.R242H	uc003bcd.1_Intron|CYP2D6_uc010gyu.2_5'UTR|CYP2D6_uc003bcf.2_Missense_Mutation_p.R191H	NM_000106	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D,	242							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			breast(1)|skin(1)	2						CTTTTGGAAGCGTAGGACCTT	0.607													T	42524294	T	T	42524294	3	4	116	1	0	0	0	0	1	0	0	0	4169	768	27	1	788	1	CYP2D6	22	42524294	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	2240746	42524294	8780272	77	7948											
TBL1X	6907	broad.mit.edu	37	chrX	9656243	9656243	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaccacgacctcagccggcGtttcccaccaaaatccatcg	6	19	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:9656243G>A	uc010ndq.2	+	7	912	c.544G>A	c.(544-546)GTT>ATT	p.V182I	TBL1X_uc004csq.3_Missense_Mutation_p.V131I|TBL1X_uc010ndr.2_Missense_Mutation_p.V131I|TBL1X_uc004csr.2_Missense_Mutation_p.V182I|TBL1X_uc004css.2_Missense_Mutation_p.V133I	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	182					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				CTCAGCCGGCGTTTCCCACCA	0.448													A	9656243	A	A	9656243	3	1	116	1	0	0	0	0	1	0	0	0	15636	1145	40	1	558	1	TBL1X	23	9656243	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08		9656243	145614317	78	7949											
POLA1	5422	broad.mit.edu	37	chrX	24759540	24759540	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacacacctggaaagatgcCaagttcattttgcagatcat	8	9	2	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:24759540C>T	uc004dbl.2	+	21	2270	c.2247C>T	c.(2245-2247)GCC>GCT	p.A749A		NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	749					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	GGAAAGATGCCAAGTTCATTT	0.348													T	24759540	T	T	24759540	2	4	116	1	0	0	0	0	0	0	0	1	12187	581	21	3		3	POLA1	23	24759540	Silent	SNP	C	TCGA-12-0692-01A-01W-0348-08	15103297	24759540	130511020	79	7950											
SATL1	340562	broad.mit.edu	37	chrX	84362599	84362599	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacttgattggctagtgcctGgttgtctcatgcctagttgg	12	8	1	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:84362599G>A	uc011mqx.1	-	1	1376	c.1376C>T	c.(1375-1377)CCA>CTA	p.P459L	SATL1_uc004een.2_Missense_Mutation_p.P459L	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	272	Gln-rich.						N-acetyltransferase activity			breast(2)	2						GCTAGTGCCTGGTTGTCTCAT	0.592													A	84362599	A	A	84362599	3	1	116	1	0	0	0	0	1	0	0	0	13855	1348	47	3	542	3	SATL1	23	84362599	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	59603059	84362599	70907961	80	7951											
PCDH11X	27328	broad.mit.edu	37	chrX	91132676	91132676	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtttctattcctgagaataaCtctcctggcatccagttgac	7	11	2	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:91132676C>G	uc004efk.1	+	2	2282	c.1437C>G	c.(1435-1437)AAC>AAG	p.N479K	PCDH11X_uc004efl.1_Missense_Mutation_p.N479K|PCDH11X_uc004efo.1_Missense_Mutation_p.N479K|PCDH11X_uc010nmv.1_Missense_Mutation_p.N479K|PCDH11X_uc004efm.1_Missense_Mutation_p.N479K|PCDH11X_uc004efn.1_Missense_Mutation_p.N479K|PCDH11X_uc004efh.1_Missense_Mutation_p.N479K|PCDH11X_uc004efj.1_Missense_Mutation_p.N479K	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	479	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTGAGAATAACTCTCCTGGCA	0.433													G	91132676	G	G	91132676	3	3	116	1	0	0	0	0	1	0	0	0	11508	564	20	5	1443	5	PCDH11X	23	91132676	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	6770077	91132676	64137884	81	7952			1	28		2	2	29	N	C_A	7.95918e-05
PCDH11X	27328	broad.mit.edu	37	chrX	91132704	91132704	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcatccagttgacgaaagtaAgtgcaatggatgcagacagt	12	7	0	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:91132704A>T	uc004efk.1	+	2	2310	c.1465A>T	c.(1465-1467)AGT>TGT	p.S489C	PCDH11X_uc004efl.1_Missense_Mutation_p.S489C|PCDH11X_uc004efo.1_Missense_Mutation_p.S489C|PCDH11X_uc010nmv.1_Missense_Mutation_p.S489C|PCDH11X_uc004efm.1_Missense_Mutation_p.S489C|PCDH11X_uc004efn.1_Missense_Mutation_p.S489C|PCDH11X_uc004efh.1_Missense_Mutation_p.S489C|PCDH11X_uc004efj.1_Missense_Mutation_p.S489C	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	489	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GACGAAAGTAAGTGCAATGGA	0.453													T	91132704	T	T	91132704	3	4	116	1	0	0	0	0	1	0	0	0	11508	72	3	5	1471	5	PCDH11X	23	91132704	Missense_Mutation	SNP	A	TCGA-12-0692-01A-01W-0348-08	28	91132704	64137856	82	7953			1	28		2	2	29	N	C_A	7.95918e-05
LONRF3	79836	broad.mit.edu	37	chrX	118108897	118108897	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccccgcacctctaccgacgCgggagccagagcaagagcag	13	16	1	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:118108897C>T	uc004eqw.2	+	1	185	c.154C>T	c.(154-156)CGG>TGG	p.R52W	LONRF3_uc004eqx.2_Missense_Mutation_p.R52W|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_5'Flank	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	52					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						TCTACCGACGCGGGAGCCAGA	0.677													T	118108897	T	T	118108897	3	4	116	1	0	0	0	0	1	0	0	0	8896	759	27	1	156	1	LONRF3	23	118108897	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	26976193	118108897	37161663	83	7954											
ZBTB33	10009	broad.mit.edu	37	chrX	119388318	119388318	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccagtcctgactcggccGtcagtaatacatctttggtc	9	13	2	1			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:119388318G>A	uc004esn.1	+	2	1276	c.1048G>A	c.(1048-1050)GTC>ATC	p.V350I	ZBTB33_uc010nqm.1_Missense_Mutation_p.V350I	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	350					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TGACTCGGCCGTCAGTAATAC	0.413													A	119388318	A	A	119388318	3	1	116	1	0	0	0	0	1	0	0	0	17533	1145	40	1	1050	1	ZBTB33	23	119388318	Missense_Mutation	SNP	G	TCGA-12-0692-01A-01W-0348-08	1279421	119388318	35882242	84	7955											
STAG2	10735	broad.mit.edu	37	chrX	123176479	123176479	+	Frame_Shift_Del	DEL	C	-	-													tgagataattcgaaaaatgaCtgaagaattcgatgaggtaa							TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:123176479delC	uc004etz.3	+	6	785	c.446delC	c.(445-447)ACTfs	p.T149fs	STAG2_uc004eua.2_Frame_Shift_Del_p.T149fs|STAG2_uc004eub.2_Frame_Shift_Del_p.T149fs|STAG2_uc004euc.2_Frame_Shift_Del_p.T149fs|STAG2_uc004eud.2_Frame_Shift_Del_p.T149fs|STAG2_uc004eue.2_Frame_Shift_Del_p.T149fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	149					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CGAAAAATGACTGAAGAATTC	0.299													-	123176479	-	-	123176479	7	5	116	1	0	1	0	1	0	0	0	0	15242	565	20	0	464	0	STAG2	23	123176479	Frame_Shift_Del	DEL	C	TCGA-12-0692-01A-01W-0348-08	3788161	123176479	32094081	85	7956											
RBMX	27316	broad.mit.edu	37	chrX	135961585	135961586	+	Frame_Shift_Ins	INS	-	T	T													tgggcgatctgcttcaaccaINStgtttttttttttttgggcc							TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:135961585_135961586insT	uc004fae.1	-	2	211_212	c.1_2insA	c.(1-3)ATGfs	p.M1fs	RBMX_uc011mwf.1_Frame_Shift_Ins_p.M1fs|RBMX_uc004fad.1_Frame_Shift_Ins_p.M1fs|RBMX_uc011mwg.1_Translation_Start_Site|RBMX_uc004faf.1_Translation_Start_Site|RBMX_uc010nsf.1_Intron|RBMX_uc004fag.1_Intron|SNORD61_uc004fah.1_5'Flank	NM_002139	NP_002130	P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked isoform 1	1						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TGCTTCAACCATGTTTTTTTTT	0.391													T	135961586	T	T	135961585	7	5	116	1	0	1	1	0	0	0	0	0	13151	217	8	0	1260	0	RBMX	23	135961585	Frame_Shift_Ins	INS	-	TCGA-12-0692-01A-01W-0348-08	12785106	135961585	19308975	86	7957											
PLXNB3	5365	broad.mit.edu	37	chrX	153033075	153033075	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtaccgctcctacgtggccCgcgtctgcctgggggacacc	13	16	1	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:153033075C>T	uc004fii.2	+	3	967	c.793C>T	c.(793-795)CGC>TGC	p.R265C	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Intron|PLXNB3_uc010nuk.2_Missense_Mutation_p.R288C|PLXNB3_uc011mzd.1_Intron	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	265	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CTACGTGGCCCGCGTCTGCCT	0.607													T	153033075	T	T	153033075	3	4	116	1	0	0	0	0	1	0	0	0	12125	652	23	2	917	2	PLXNB3	23	153033075	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	17071490	153033075	2237485	87	7958											
FLNA	2316	broad.mit.edu	37	chrX	153588484	153588484	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatggtgacggtgtaggcccCggggcagaggggaatgtagg	21	6	0	2			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:153588484C>T	uc004fkk.2	-	22	3928	c.3679G>A	c.(3679-3681)GGG>AGG	p.G1227R	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Missense_Mutation_p.G1227R	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1227	Filamin 10.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTGTAGGCCCCGGGGCAGAGG	0.637													T	153588484	T	T	153588484	3	4	116	1	0	0	0	0	1	0	0	0	5933	652	23	2	4372	2	FLNA	23	153588484	Missense_Mutation	SNP	C	TCGA-12-0692-01A-01W-0348-08	555409	153588484	1682076	88	7959											
PLXNA3	55558	broad.mit.edu	37	chrX	153694763	153694763	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagccgtggcccggcgtcCgggggcacacggcttaccat	14	17	0	0			TCGA-12-0692-01A-01W-0348-08	TCGA-12-0692-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	937fb2a6-3856-4086-a327-8d8e593b7b7b	ca93c2cd-b482-4edb-9ca8-a2e900c4f94a	g.chrX:153694763C>T	uc004flm.2	+	16	3017	c.2844C>T	c.(2842-2844)TCC>TCT	p.S948S		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	948	IPT/TIG 2.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCCGGCGTCCGGGGGCACAC	0.672													T	153694763	T	T	153694763	2	4	116	1	0	0	0	0	0	0	0	1	12121	639	23	2		2	PLXNA3	23	153694763	Silent	SNP	C	TCGA-12-0692-01A-01W-0348-08	106279	153694763	1575797	89	7960											
TNFRSF8	943	broad.mit.edu	37	chr1	12170201	12170201	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcctcgcccaggaagctgctTctaaactgacgagggctccc	11	15	1	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:12170201T>A	uc001atq.2	+	6	838	c.616T>A	c.(616-618)TCT>ACT	p.S206T	TNFRSF8_uc010obc.1_Missense_Mutation_p.S95T	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	206	Extracellular (Potential).|TNFR-Cys 4.				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		GGAAGCTGCTTCTAAACTGAC	0.632													A	12170201	A	A	12170201	3	1	117	1	0	0	0	0	1	0	0	0	16296	1783	62	5	638	5	TNFRSF8	1	12170201	Missense_Mutation	SNP	T	TCGA-12-0821-01A-01W-0424-08		12170201	237080420	1	7961											
TAS1R2	80834	broad.mit.edu	37	chr1	19181287	19181287	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatgtcgcgccgggccacgCgctcgccaagcagctggcca	14	16	0	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:19181287C>T	uc001bba.1	-	3	678	c.677G>A	c.(676-678)CGC>CAC	p.R226H		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	226	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CCGGGCCACGCGCTCGCCAAG	0.642													T	19181287	T	T	19181287	3	4	117	1	0	0	0	0	1	0	0	0	15560	768	27	1	1858	1	TAS1R2	1	19181287	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	7011086	19181287	230069334	2	7962											
CNKSR1	10256	broad.mit.edu	37	chr1	26515154	26515154	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgcagccacccccacacaGcgcagcccacggacctcctt	7	22	0	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:26515154G>A	uc001bln.3	+	19	1735	c.1677G>A	c.(1675-1677)CAG>CAA	p.Q559Q	CNKSR1_uc001blm.3_Silent_p.Q552Q|CNKSR1_uc009vsd.2_Silent_p.Q294Q|CNKSR1_uc009vse.2_Silent_p.Q294Q|CNKSR1_uc001blo.2_Silent_p.Q294Q|CATSPER4_uc010oey.1_5'Flank|CATSPER4_uc010oez.1_5'Flank|CATSPER4_uc009vsf.2_5'Flank	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	559					Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCCACACAGCGCAGCCCAC	0.647													A	26515154	A	A	26515154	2	1	117	1	0	0	0	0	0	0	0	1	3606	962	34	3		3	CNKSR1	1	26515154	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08	7333867	26515154	222735467	3	7963											
ZSWIM5	57643	broad.mit.edu	37	chr1	45553632	45553632	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtaggaagaacttcagtgtgGtgtgccgtgattaaatattg	13	4	1	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:45553632G>A	uc001cnd.2	-	2	1101	c.873C>T	c.(871-873)CAC>CAT	p.H291H		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	291							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					CTTCAGTGTGGTGTGCCGTGA	0.393													A	45553632	A	A	45553632	2	1	117	1	0	0	0	0	0	0	0	1	18241	1252	44	3		3	ZSWIM5	1	45553632	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08	19038478	45553632	203696989	4	7964											
AK5	26289	broad.mit.edu	37	chr1	78001682	78001682	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctactaccgagcgtccatcCccgtgatcgcctactacgag	8	17	0	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:78001682C>T	uc001dhn.2	+	13	1836	c.1579C>T	c.(1579-1581)CCC>TCC	p.P527S	AK5_uc001dho.2_Missense_Mutation_p.P501S	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	527					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						AGCGTCCATCCCCGTGATCGC	0.527													T	78001682	T	T	78001682	3	4	117	1	0	0	0	0	1	0	0	0	443	623	22	3	1629	3	AK5	1	78001682	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	32448050	78001682	171248939	5	7965											
MCOLN3	55283	broad.mit.edu	37	chr1	85498465	85498465	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtttaaactgaagctccaCtgttaggagtctagaaaaca	8	8	1	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:85498465C>T	uc001dkp.2	-	6	739	c.646G>A	c.(646-648)GTG>ATG	p.V216M	MCOLN3_uc001dkq.2_Missense_Mutation_p.V160M|MCOLN3_uc001dkr.2_Missense_Mutation_p.V216M|MCOLN3_uc001dks.3_Missense_Mutation_p.V61M	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	216						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		TGAAGCTCCACTGTTAGGAGT	0.438													T	85498465	T	T	85498465	3	4	117	1	0	0	0	0	1	0	0	0	9397	565	20	3	1047	3	MCOLN3	1	85498465	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	7496783	85498465	163752156	6	7966											
INSRR	3645	broad.mit.edu	37	chr1	156811514	156811514	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggactcgggggccatccagCgcacgggcagcagccccttc	15	16	0	0	rs139192917		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:156811514C>T	uc010pht.1	-	20	3724	c.3470G>A	c.(3469-3471)CGC>CAC	p.R1157H	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	1157	Cytoplasmic (Potential).|Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGCCATCCAGCGCACGGGCAG	0.627													T	156811514	T	T	156811514	3	4	117	1	0	0	0	0	1	0	0	0	7774	768	27	1	434	1	INSRR	1	156811514	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	71313049	156811514	92439107	7	7967											
CD1B	910	broad.mit.edu	37	chr1	158299678	158299678	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcttttcctgcattgaggaCgcccaagagatatcgggggc	13	10	0	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:158299678C>T	uc001frx.2	-	3	679	c.571G>A	c.(571-573)GTC>ATC	p.V191I	CD1B_uc001frw.2_Missense_Mutation_p.V84I	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	191	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					GCATTGAGGACGCCCAAGAGA	0.438													T	158299678	T	T	158299678	3	4	117	1	0	0	0	0	1	0	0	0	2975	536	19	1	446	1	CD1B	1	158299678	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	1488164	158299678	90950943	8	7968											
OR10R2	343406	broad.mit.edu	37	chr1	158449688	158449688	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atgccccaaattcttatattCacatacctgaatatgtttta	3	9	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:158449688C>G	uc010pik.1	+	1	21	c.21C>G	c.(19-21)TTC>TTG	p.F7L	uc001fso.1_Intron	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TTCTTATATTCACATACCTGA	0.279													G	158449688	G	G	158449688	3	3	117	1	0	0	0	0	1	0	0	0	10917	825	29	5	23	5	OR10R2	1	158449688	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	150010	158449688	90800933	9	7969											
LY9	4063	broad.mit.edu	37	chr1	160786529	160786529	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cagaaggaagctgttgtgtcCcaaggggaatcacacctcaa	11	10	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:160786529C>G	uc001fwu.2	+	5	1268	c.1218C>G	c.(1216-1218)TCC>TCG	p.S406S	LY9_uc001fwv.2_Silent_p.S406S|LY9_uc001fww.2_Intron|LY9_uc001fwx.2_Intron|LY9_uc001fwy.1_Intron|LY9_uc001fwz.2_Silent_p.S58S	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	406	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTGTTGTGTCCCAAGGGGAAT	0.557													G	160786529	G	G	160786529	2	3	117	1	0	0	0	0	0	0	0	1	9101	610	22	5		5	LY9	1	160786529	Silent	SNP	C	TCGA-12-0821-01A-01W-0424-08	2336841	160786529	88464092	10	7970											
CR2	1380	broad.mit.edu	37	chr1	207648560	207648560	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgccaacttgtatcaaaaaAggtaagatacttggaaggga	11	5	1	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr1:207648560A>C	uc001hfw.2	+	13	2632	c.2538A>C	c.(2536-2538)AAA>AAC	p.K846N	CR2_uc001hfv.2_Missense_Mutation_p.K905N|CR2_uc009xch.2_Missense_Mutation_p.K846N	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	846	Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						GTATCAAAAAAGGTAAGATAC	0.398													C	207648560	C	C	207648560	3	2	117	1	0	0	0	0	1	0	0	0	3842	86	3	5	2769	5	CR2	1	207648560	Missense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08	46862031	207648560	41602061	11	7971											
DCTN1	1639	broad.mit.edu	37	chr2	74592698	74592698	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agccgagtctggactttctcGatgcgctcatctgcatcctt	9	13	4	0	rs140969689	by1000genomes	TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr2:74592698G>A	uc002skx.2	-	25	3284	c.2973C>T	c.(2971-2973)ATC>ATT	p.I991I	SLC4A5_uc002skl.2_5'Flank|DCTN1_uc002skt.1_5'Flank|DCTN1_uc002skv.2_Silent_p.I857I|DCTN1_uc002sku.2_Silent_p.I857I|DCTN1_uc002skw.1_Silent_p.I967I|DCTN1_uc010ffd.2_Silent_p.I971I|DCTN1_uc002sky.2_Silent_p.I954I	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	991	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						GGACTTTCTCGATGCGCTCAT	0.577													A	74592698	A	A	74592698	2	1	117	1	0	0	0	0	0	0	0	1	4306	1048	37	2		2	DCTN1	2	74592698	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08		74592698	168606675	12	7972											
PSD4	23550	broad.mit.edu	37	chr2	113940791	113940791	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcaaccccctcttcctggCgagtccttgctcagagaaca	8	16	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr2:113940791C>T	uc002tjc.2	+	2	941	c.758C>T	c.(757-759)GCG>GTG	p.A253V	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.A252V|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	253					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CTCTTCCTGGCGAGTCCTTGC	0.602													T	113940791	T	T	113940791	3	4	117	1	0	0	0	0	1	0	0	0	12649	768	27	1	760	1	PSD4	2	113940791	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	39348093	113940791	129258582	13	7973											
SCN9A	6335	broad.mit.edu	37	chr2	167056293	167056293	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctttgactagacgtaggattCggccaatcctggcaagacgg	12	10	0	3	rs142201175		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr2:167056293C>T	uc010fpl.2	-	27	5164	c.4823G>A	c.(4822-4824)CGA>CAA	p.R1608Q	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1619	Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).|IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R1608Q(1)		ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ACGTAGGATTCGGCCAATCCT	0.483													T	167056293	T	T	167056293	3	4	117	1	0	0	0	0	1	0	0	0	13925	884	31	2	1114	2	SCN9A	2	167056293	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	53115502	167056293	76143080	14	7974											
FRZB	2487	broad.mit.edu	37	chr2	183703198	183703198	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcattaacattaagtggagGgcagaggcagccagagctgg	14	8	1	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr2:183703198G>A	uc002upa.1	-	4	954	c.736C>T	c.(736-738)CCT>TCT	p.P246S		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	246	NTR.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			TTAAGTGGAGGGCAGAGGCAG	0.438													A	183703198	A	A	183703198	3	1	117	1	0	0	0	0	1	0	0	0	6065	1232	43	3	253	3	FRZB	2	183703198	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	16646905	183703198	59496175	15	7975											
COL5A2	1290	broad.mit.edu	37	chr2	189927922	189927923	+	Frame_Shift_Ins	INS	-	C	C													tacctttggggcctggaaggINScccatgctcccgggctgccc							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr2:189927922_189927923insC	uc002uqk.2	-	27	2119_2120	c.1844_1845insG	c.(1843-1845)GGCfs	p.G615fs	COL5A2_uc010frx.2_Frame_Shift_Ins_p.G191fs	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	615					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGCCTGGAAGGCCCATGCTCCC	0.52													C	189927923	C	C	189927922	7	5	117	1	0	1	1	0	0	0	0	0	3697	1190	42	0	2766	0	COL5A2	2	189927922	Frame_Shift_Ins	INS	-	TCGA-12-0821-01A-01W-0424-08	6224724	189927922	53271451	16	7976											
IRS1	3667	broad.mit.edu	37	chr2	227659846	227659846	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggttgatgagggggtgggggTgggggaggctgcggttcagg	26	3	1	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr2:227659846T>G	uc002voh.3	-	1	3661	c.3609A>C	c.(3607-3609)CCA>CCC	p.P1203P		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	1203	Pro-rich.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GGGGTGGGGGTGGGGGAGGCT	0.582													G	227659846	G	G	227659846	2	3	117	1	0	0	0	0	0	0	0	1	7840	1683	59	5		5	IRS1	2	227659846	Silent	SNP	T	TCGA-12-0821-01A-01W-0424-08	37731924	227659846	15539527	17	7977											
ECEL1	9427	broad.mit.edu	37	chr2	233346218	233346218	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcaggtgggggtctcacccGctggttgtagacagtgaagt	17	8	1	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr2:233346218G>A	uc002vsv.2	-	14	2192	c.1987C>T	c.(1987-1989)CGG>TGG	p.R663W	ECEL1_uc010fya.1_Missense_Mutation_p.R661W|ECEL1_uc010fyb.1_Missense_Mutation_p.R370W	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	663	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGTCTCACCCGCTGGTTGTAG	0.622													A	233346218	A	A	233346218	3	1	117	1	0	0	0	0	1	0	0	0	4891	1086	38	1	360	1	ECEL1	2	233346218	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	5686372	233346218	9853155	18	7978											
OXSR1	9943	broad.mit.edu	37	chr3	38278405	38278405	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggagtggagtgatgatgaaTttgatgaagaaagtgaggaa	17	0	0	7			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr3:38278405T>C	uc003chy.2	+	11	1369	c.1027T>C	c.(1027-1029)TTT>CTT	p.F343L	OXSR1_uc010hhb.2_Missense_Mutation_p.F277L	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	343					intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TGATGATGAATTTGATGAAGA	0.423													C	38278405	C	C	38278405	3	2	117	1	0	0	0	0	1	0	0	0	11336	1493	52	4	1069	4	OXSR1	3	38278405	Missense_Mutation	SNP	T	TCGA-12-0821-01A-01W-0424-08		38278405	159744025	19	7979											
PRSS50	29122	broad.mit.edu	37	chr3	46759087	46759087	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctctggtcggcgggatcagcAgtggacagcgcccccggggc	17	14	2	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr3:46759087A>C	uc003cqe.1	-	2	206	c.147T>G	c.(145-147)ACT>ACG	p.T49T	PRSS50_uc003cqf.1_Intron	NM_013270	NP_037402	Q9UI38	TSP50_HUMAN	testes-specific protease 50 precursor	49					proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity				0						CGGGATCAGCAGTGGACAGCG	0.706													C	46759087	C	C	46759087	2	2	117	1	0	0	0	0	0	0	0	1	12631	175	7	5		5	PRSS50	3	46759087	Silent	SNP	A	TCGA-12-0821-01A-01W-0424-08	8480682	46759087	151263343	20	7980											
CNTN3	5067	broad.mit.edu	37	chr3	74420493	74420493	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcctgggagacaaatctcCgactatcttcttcaacaaac	5	13	5	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr3:74420493C>T	uc003dpm.1	-	5	592	c.512G>A	c.(511-513)CGG>CAG	p.R171Q		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	171	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GACAAATCTCCGACTATCTTC	0.403													T	74420493	T	T	74420493	3	4	117	1	0	0	0	0	1	0	0	0	3642	652	23	2	2646	2	CNTN3	3	74420493	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	27661406	74420493	123601937	21	7981											
OR5H6	79295	broad.mit.edu	37	chr3	97983841	97983841	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatatcttatacaattatccTctttacaatcttagaaaaga	2	7	3	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr3:97983841T>C	uc003dsi.1	+	1	713	c.713T>C	c.(712-714)CTC>CCC	p.L238P		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	238	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						ACAATTATCCTCTTTACAATC	0.353													C	97983841	C	C	97983841	3	2	117	1	0	0	0	0	1	0	0	0	11163	1551	54	4	715	4	OR5H6	3	97983841	Missense_Mutation	SNP	T	TCGA-12-0821-01A-01W-0424-08	23563348	97983841	100038589	22	7982											
CCDC54	84692	broad.mit.edu	37	chr3	107096949	107096949	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatcacagaactgctttacaAactcatacaaccagcaactc	3	13	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr3:107096949A>C	uc003dwi.1	+	1	762	c.515A>C	c.(514-516)AAA>ACA	p.K172T		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	172											0						CTGCTTTACAAACTCATACAA	0.433													C	107096949	C	C	107096949	3	2	117	1	0	0	0	0	1	0	0	0	2824	14	1	5	517	5	CCDC54	3	107096949	Missense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08	9113108	107096949	90925481	23	7983											
ATR	545	broad.mit.edu	37	chr3	142234329	142234329	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggcttctttactccagaccAatcggttgacttctgagaac	8	11	2	3			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr3:142234329A>G	uc003eux.3	-	25	4533	c.4411T>C	c.(4411-4413)TGG>CGG	p.W1471R		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1471					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						ACTCCAGACCAATCGGTTGAC	0.318								Other_conserved_DNA_damage_response_genes					G	142234329	G	G	142234329	3	3	117	1	0	0	0	0	1	0	0	0	1204	130	5	4	3615	4	ATR	3	142234329	Missense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08	35137380	142234329	55788101	24	7984											
LEKR1	389170	broad.mit.edu	37	chr3	156710933	156710933	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agatatataaagcattacagGaagagctgactgtgaaagaa	10	4	0	5			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr3:156710933G>A	uc003fba.1	+	10	1399	c.64G>A	c.(64-66)GAA>AAA	p.E22K		NM_001004316	NP_001004316	Q6ZMV7	LEKR1_HUMAN	leucine, glutamate and lysine rich 1	42											0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AGCATTACAGGAAGAGCTGAC	0.348													A	156710933	A	A	156710933	3	1	117	1	0	0	0	0	1	0	0	0	8717	1175	41	3	1006	3	LEKR1	3	156710933	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	14476604	156710933	41311497	25	7985											
PIK3CA	5290	broad.mit.edu	37	chr3	178916614	178916614	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acttgcaaagaatcagaacaAtgcctccacgaccatcatca	5	13	3	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr3:178916614A>G	uc003fjk.2	+	2	158	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATCAGAACAATGCCTCCACG	0.378		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			G	178916614	G	G	178916614	3	3	117	1	0	0	0	0	1	0	0	0	11913	101	4	4	3	4	PIK3CA	3	178916614	Missense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08	22205681	178916614	19105816	26	7986											
TNK2	10188	broad.mit.edu	37	chr3	195595228	195595229	+	Frame_Shift_Ins	INS	-	G	G													ccacgtcgtcataggcgggcINSggggggggcagcgggcgtgc							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr3:195595228_195595229insG	uc003fvu.1	-	12	2438_2439	c.1895_1896insC	c.(1894-1896)CCGfs	p.P632fs	TNK2_uc003fvq.1_Frame_Shift_Ins_p.P39fs|TNK2_uc003fvr.1_Frame_Shift_Ins_p.P157fs|TNK2_uc003fvs.1_Frame_Shift_Ins_p.P664fs|TNK2_uc003fvt.1_Frame_Shift_Ins_p.P710fs|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_3'UTR	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	632	Required for interaction with SRC.|Required for interaction with NEDD4 (By similarity).|Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CATAGGCGGGCGGGGGGGGCAG	0.728													G	195595229	G	G	195595228	7	5	117	1	0	1	1	0	0	0	0	0	16315	755	27	0	1236	0	TNK2	3	195595228	Frame_Shift_Ins	INS	-	TCGA-12-0821-01A-01W-0424-08	16678614	195595228	2427202	27	7987											
FGFRL1	53834	broad.mit.edu	37	chr4	1018839	1018839	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggcccagaagaagccgtgcAcccccgcgcctgcccctccc	10	21	0	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr4:1018839A>C	uc003gce.2	+	7	1380	c.1219A>C	c.(1219-1221)ACC>CCC	p.T407P	FGFRL1_uc003gcf.2_Missense_Mutation_p.T407P|FGFRL1_uc003gcg.2_Missense_Mutation_p.T407P|FGFRL1_uc010ibo.2_Missense_Mutation_p.T407P	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	407	Cytoplasmic (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GAAGCCGTGCACCCCCGCGCC	0.731													C	1018839	C	C	1018839	3	2	117	1	0	0	0	0	1	0	0	0	5869	159	6	5	1241	5	FGFRL1	4	1018839	Missense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08		1018839	190135437	28	7988											
DRD5	1816	broad.mit.edu	37	chr4	9784657	9784657	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccctccggccggcttcccctGcgtcagtgagaccaccttcg	10	19	1	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr4:9784657G>T	uc003gmb.3	+	1	1400	c.1004G>T	c.(1003-1005)TGC>TTC	p.C335F		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	335	Extracellular (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GGCTTCCCCTGCGTCAGTGAG	0.587													T	9784657	T	T	9784657	3	4	117	1	0	0	0	0	1	0	0	0	4760	1319	46	5	1006	5	DRD5	4	9784657	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	8765818	9784657	181369619	29	7989											
NKX3-2	579	broad.mit.edu	37	chr4	13543971	13543971	+	Silent	SNP	C	G	G													cgctccagctcgaagacctgCgcgtgggagaaagcggcccg							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr4:13543971C>G	uc003gmx.2	-	2	724	c.648G>C	c.(646-648)GCG>GCC	p.A216A		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	216	Homeobox.				negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGAAGACCTGCGCGTGGGAGA	0.502													G	13543971	G	G	13543971	2	3	117	1	0	0	0	0	0	0	0	1	10456	755	27	5		5	NKX3-2	4	13543971	Silent	SNP	C	TCGA-12-0821-01A-01W-0424-08	3759314	13543971	177610305	30	7990	11	2									
NKX3-2	579	broad.mit.edu	37	chr4	13543978	13543978	+	Missense_Mutation	SNP	G	A	A													gctcgaagacctgcgcgtggGagaaagcggcccgcgagcgc							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr4:13543978G>A	uc003gmx.2	-	2	717	c.641C>T	c.(640-642)TCC>TTC	p.S214F		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	214	Homeobox.				negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTGCGCGTGGGAGAAAGCGGC	0.478													A	13543978	A	A	13543978	3	1	117	1	0	0	0	0	1	0	0	0	10456	1174	41	3	364	3	NKX3-2	4	13543978	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	7	13543978	177610298	31	7991	11	2									
KLF3	51274	broad.mit.edu	37	chr4	38698729	38698729	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aaccctacaaatgtacatggGaagggtgcacatggaagttt	11	7	0	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr4:38698729G>T	uc003gth.3	+	6	1215	c.883G>T	c.(883-885)GAA>TAA	p.E295*		NM_016531	NP_057615	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	295	C2H2-type 2.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						ATGTACATGGGAAGGGTGCAC	0.403													T	38698729	T	T	38698729	4	4	117	1	0	0	0	0	0	1	0	0	8347	1175	41	5	901	5	KLF3	4	38698729	Nonsense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	25154751	38698729	152455547	32	7992											
TLL1	7092	broad.mit.edu	37	chr4	166978363	166978363	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagtgtgccaaacctgaccGtggaggctgtgagcagcgat	15	9	0	3	rs141877254		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr4:166978363G>A	uc003irh.1	+	14	2395	c.1748G>A	c.(1747-1749)CGT>CAT	p.R583H	TLL1_uc011cjn.1_Missense_Mutation_p.R606H|TLL1_uc011cjo.1_Missense_Mutation_p.R407H	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	583	EGF-like 1; calcium-binding (Potential).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AAACCTGACCGTGGAGGCTGT	0.438													A	166978363	A	A	166978363	3	1	117	1	0	0	0	0	1	0	0	0	15942	1145	40	1	1802	1	TLL1	4	166978363	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	128279634	166978363	24175913	33	7993											
GPR98	84059	broad.mit.edu	37	chr5	89910651	89910651	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atttttttctttttgttttaGggatgccctctgcatcttta	6	7	3	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr5:89910651G>T	uc003kju.2	+	2	119	c.23_splice	c.e2-1	p.G8_splice	GPR98_uc003kjt.2_Splice_Site	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor						cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTTGTTTTAGGGATGCCCTC	0.274													T	89910651	T	T	89910651	5	4	117	1	0	0	0	0	0	0	1	0	6721	1014	35	5	28	5	GPR98	5	89910651	Splice_Site	SNP	G	TCGA-12-0821-01A-01W-0424-08		89910651	91004609	34	7994											
SLCO6A1	133482	broad.mit.edu	37	chr5	101724473	101724473	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacatttattaacatcccGtaaaatacaagaagtttctc	3	10	1	1	rs140805258	byFrequency	TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr5:101724473G>A	uc003knn.2	-	12	2108	c.1936C>T	c.(1936-1938)CGG>TGG	p.R646W	SLCO6A1_uc003kno.2_Missense_Mutation_p.R393W|SLCO6A1_uc003knp.2_Missense_Mutation_p.R646W|SLCO6A1_uc003knq.2_Missense_Mutation_p.R584W	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	646	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TTAACATCCCGTAAAATACAA	0.313													A	101724473	A	A	101724473	3	1	117	1	0	0	0	0	1	0	0	0	14732	1144	40	1	231	1	SLCO6A1	5	101724473	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	11813822	101724473	79190787	35	7995											
CD14	929	broad.mit.edu	37	chr5	140011717	140011717	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgttccagcccagcgaaCgacagattgagggagttcag	12	11	1	2	rs150900616		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr5:140011717C>T	uc003lgi.1	-	2	1206	c.852G>A	c.(850-852)TCG>TCA	p.S284S	CD14_uc003lgj.1_Silent_p.S284S	NM_000591	NP_000582	P08571	CD14_HUMAN	CD14 antigen precursor	284	LRR 9.				apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCAGCGAACGACAGATTGA	0.617													T	140011717	T	T	140011717	2	4	117	1	0	0	0	0	0	0	0	1	2964	523	19	1		1	CD14	5	140011717	Silent	SNP	C	TCGA-12-0821-01A-01W-0424-08	38287244	140011717	40903543	36	7996											
WWC1	23286	broad.mit.edu	37	chr5	167880985	167880985	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	catcacaggaggtatgaggaGaccagtgagaatgaggcagt	15	6	1	4			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr5:167880985G>A	uc003lzu.2	+	18	2631	c.2538G>A	c.(2536-2538)GAG>GAA	p.E846E	WWC1_uc003lzv.2_Silent_p.E846E|WWC1_uc011den.1_Silent_p.E846E|WWC1_uc003lzw.2_Silent_p.E645E|WWC1_uc010jjf.1_Silent_p.E118E	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	846	Glu-rich.|Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GGTATGAGGAGACCAGTGAGA	0.403													A	167880985	A	A	167880985	2	1	117	1	0	0	0	0	0	0	0	1	17408	933	33	3		3	WWC1	5	167880985	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08	27869268	167880985	13034275	37	7997											
FLOT1	10211	broad.mit.edu	37	chr6	30697825	30697826	+	Frame_Shift_Del	DEL	TT	-	-													gatgctcacgcctgtgagtcTttccacactctctggcaggc					rs113030936		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr6:30697825_30697826delTT	uc003nrm.2	-	12	1391_1392	c.1227_1228delAA	c.(1225-1230)GAAAGAfs	p.E409fs	FLOT1_uc011dmr.1_Frame_Shift_Del_p.E361fs	NM_005803	NP_005794	O75955	FLOT1_HUMAN	flotillin 1	409_410						centriolar satellite|endosome|integral to membrane|melanosome|membrane fraction					0						CCTGTGAGTCTTTCCACACTCT	0.53													-	30697826	-	-	30697825	7	5	117	1	0	1	0	1	0	0	0	0	5936	1617	56	0	63	0	FLOT1	6	30697825	Frame_Shift_Del	DEL	TT	TCGA-12-0821-01A-01W-0424-08		30697825	140417242	38	7998											
STK19	8859	broad.mit.edu	37	chr6	31939829	31939830	+	Frame_Shift_Ins	INS	-	A	A													attcagcgacagtggcgggcINSaaacccctcccggggcgggg							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr6:31939829_31939830insA	uc003nyv.2	+	1	184_185	c.56_57insA	c.(55-57)GCAfs	p.A19fs	DOM3Z_uc003nyo.1_5'UTR|DOM3Z_uc003nyp.1_5'UTR|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_5'UTR|DOM3Z_uc003nys.1_5'Flank|DOM3Z_uc010jtl.1_5'UTR|STK19_uc003nyt.2_5'UTR|DOM3Z_uc003nyu.1_5'UTR|STK19_uc011dow.1_Frame_Shift_Ins_p.A19fs|STK19_uc011dox.1_5'UTR|STK19_uc003nyw.2_Frame_Shift_Ins_p.A19fs|STK19_uc010jtn.1_5'Flank	NM_032454	NP_115830	P49842	STK19_HUMAN	serine/threonine kinase 19 isoform 2	19						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(4)	4						CAGTGGCGGGCAAACCCCTCCC	0.634													A	31939830	A	A	31939829	7	5	117	1	0	1	1	0	0	0	0	0	15291	710	25	0	58	0	STK19	6	31939829	Frame_Shift_Ins	INS	-	TCGA-12-0821-01A-01W-0424-08	1242004	31939829	139175238	39	7999											
LGSN	51557	broad.mit.edu	37	chr6	63990164	63990164	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agacctcattactgctatgaAgtccatctaagccggcagca	8	12	2	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr6:63990164A>C	uc003peh.2	-	4	1326	c.1292T>G	c.(1291-1293)CTT>CGT	p.L431R	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	431					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	ACTGCTATGAAGTCCATCTAA	0.478													C	63990164	C	C	63990164	3	2	117	1	0	0	0	0	1	0	0	0	8759	72	3	5	241	5	LGSN	6	63990164	Missense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08	32050335	63990164	107124903	40	8000											
FILIP1	27145	broad.mit.edu	37	chr6	76024397	76024397	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccatttcaagcacacgctttCgaagattttccacttctgcc	5	14	2	1	rs147080592		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr6:76024397C>T	uc003pia.2	-	5	1524	c.1151G>A	c.(1150-1152)CGA>CAA	p.R384Q	FILIP1_uc003phy.1_Missense_Mutation_p.R384Q|FILIP1_uc003phz.2_Missense_Mutation_p.R285Q|FILIP1_uc010kbe.2_Missense_Mutation_p.R387Q|FILIP1_uc003pib.1_Missense_Mutation_p.R136Q	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	384	Potential.							p.R384Q(1)		skin(3)|ovary(1)	4						CACACGCTTTCGAAGATTTTC	0.418													T	76024397	T	T	76024397	3	4	117	1	0	0	0	0	1	0	0	0	5894	884	31	2	2498	2	FILIP1	6	76024397	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	12034233	76024397	95090670	41	8001											
CASP8AP2	9994	broad.mit.edu	37	chr6	90577200	90577200	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcagggctttcattgccGgttcatcctgatgtgttgga	11	9	4	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr6:90577200G>A	uc003pnr.2	+	8	4387	c.4191G>A	c.(4189-4191)CCG>CCA	p.P1397P	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Silent_p.P1397P|CASP8AP2_uc011dzz.1_Silent_p.P1397P	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1397					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TTTCATTGCCGGTTCATCCTG	0.393													A	90577200	A	A	90577200	2	1	117	1	0	0	0	0	0	0	0	1	2678	1103	39	2		2	CASP8AP2	6	90577200	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08	14552803	90577200	80537867	42	8002											
SYNE1	23345	broad.mit.edu	37	chr6	152461140	152461140	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcagtgctgagttccagaCgctggagctgttccaactcc	11	12	1	2	rs143049227		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr6:152461140C>T	uc010kiw.2	-	140	26005	c.25403G>A	c.(25402-25404)CGT>CAT	p.R8468H	SYNE1_uc010kiv.2_Missense_Mutation_p.R2992H|SYNE1_uc003qos.3_Missense_Mutation_p.R2992H|SYNE1_uc003qot.3_Missense_Mutation_p.R8420H|SYNE1_uc003qou.3_Missense_Mutation_p.R8468H|SYNE1_uc003qop.3_Missense_Mutation_p.R653H|SYNE1_uc011eez.1_Missense_Mutation_p.R670H|SYNE1_uc003qoq.3_Missense_Mutation_p.R670H|SYNE1_uc003qor.3_Missense_Mutation_p.R1391H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8468	Cytoplasmic (Potential).|Spectrin 31.		R -> H (in a colorectal cancer sample; somatic mutation).		cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.R8468H(1)		central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAGTTCCAGACGCTGGAGCTG	0.557										HNSCC(10;0.0054)			T	152461140	T	T	152461140	3	4	117	1	0	0	0	0	1	0	0	0	15442	536	19	1	1018	1	SYNE1	6	152461140	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	61883940	152461140	18653927	43	8003											
FNDC1	84624	broad.mit.edu	37	chr6	159653439	159653439	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacccagggcacctctcatcGtccttccctgcctgccagct	7	20	1	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr6:159653439G>A	uc010kjv.2	+	11	2095	c.1895G>A	c.(1894-1896)CGT>CAT	p.R632H	FNDC1_uc010kjw.1_Missense_Mutation_p.R517H	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	632						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		ACCTCTCATCGTCCTTCCCTG	0.682													A	159653439	A	A	159653439	3	1	117	1	0	0	0	0	1	0	0	0	5968	1145	40	1	1937	1	FNDC1	6	159653439	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	7192299	159653439	11461628	44	8004											
GPNMB	10457	broad.mit.edu	37	chr7	23309680	23309680	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tggatgtggatgagatgtgtCtgctgactgtgagacgaacc	15	6	1	3			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr7:23309680C>T	uc003swc.2	+	9	1512	c.1351C>T	c.(1351-1353)CTG>TTG	p.L451L	GPNMB_uc003swb.2_Silent_p.L439L|GPNMB_uc011jyy.1_Silent_p.L393L|GPNMB_uc011jyz.1_Silent_p.L340L	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	451	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			TGAGATGTGTCTGCTGACTGT	0.557													T	23309680	T	T	23309680	2	4	117	1	0	0	0	0	0	0	0	1	6620	912	32	3		3	GPNMB	7	23309680	Silent	SNP	C	TCGA-12-0821-01A-01W-0424-08		23309680	135828983	45	8005											
FAM188B	84182	broad.mit.edu	37	chr7	30890151	30890151	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgtggcgggcagggggccgAgagagagccgttgttgcact	20	8	0	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr7:30890151A>G	uc003tbt.2	+	10	1604	c.1527A>G	c.(1525-1527)CGA>CGG	p.R509R	FAM188B_uc010kwe.2_Silent_p.R480R|AQP1_uc011kac.1_5'Flank	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	509											0						CAGGGGGCCGAGAGAGAGCCG	0.622													G	30890151	G	G	30890151	2	3	117	1	0	0	0	0	0	0	0	1	5515	291	11	4		4	FAM188B	7	30890151	Silent	SNP	A	TCGA-12-0821-01A-01W-0424-08	7580471	30890151	128248512	46	8006											
HECW1	23072	broad.mit.edu	37	chr7	43360338	43360338	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	atgccagctcgtactttgtgGaacgtgagtacctttaccat	9	10	0	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr7:43360338G>C	uc003tid.1	+	5	1062	c.457G>C	c.(457-459)GAA>CAA	p.E153Q	HECW1_uc011kbi.1_Missense_Mutation_p.E153Q|HECW1_uc003tie.1_Missense_Mutation_p.E185Q	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	153					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GTACTTTGTGGAACGTGAGTA	0.458													C	43360338	C	C	43360338	3	2	117	1	0	0	0	0	1	0	0	0	7042	1175	41	5	467	5	HECW1	7	43360338	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	12470187	43360338	115778325	47	8007											
MUC17	140453	broad.mit.edu	37	chr7	100687031	100687031	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccccacggtgaccaccaccGctgtccccacgaatactaca	6	19	0	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr7:100687031G>A	uc003uxp.1	+	3	12387	c.12334G>A	c.(12334-12336)GCT>ACT	p.A4112T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4112	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GACCACCACCGCTGTCCCCAC	0.498													A	100687031	A	A	100687031	3	1	117	1	0	0	0	0	1	0	0	0	9974	1087	38	1	12344	1	MUC17	7	100687031	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	57326693	100687031	58451632	48	8008											
CDHR3	222256	broad.mit.edu	37	chr7	105660912	105660912	+	Frame_Shift_Del	DEL	A	-	-													cagtggatctgaaagttggcAcaaatattcagaatttcaag							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr7:105660912delA	uc003vdl.3	+	13	1855	c.1747delA	c.(1747-1749)ACAfs	p.T583fs	CDHR3_uc003vdk.2_Intron|CDHR3_uc003vdm.3_Frame_Shift_Del_p.T570fs|CDHR3_uc011klt.1_Frame_Shift_Del_p.T495fs|CDHR3_uc003vdn.2_Intron	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	583	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GAAAGTTGGCACAAATATTCA	0.428													-	105660912	-	-	105660912	7	5	117	1	0	1	0	1	0	0	0	0	3120	159	6	0	1797	0	CDHR3	7	105660912	Frame_Shift_Del	DEL	A	TCGA-12-0821-01A-01W-0424-08	4973881	105660912	53477751	49	8009											
PPP1R3A	5506	broad.mit.edu	37	chr7	113558442	113558442	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acgtatacaaaactcaacttTactgccatctttttgataag	4	9	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr7:113558442T>A	uc010ljy.1	-	1	641	c.610A>T	c.(610-612)AAA>TAA	p.K204*		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	204	CBM21.				glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						AACTCAACTTTACTGCCATCT	0.318													A	113558442	A	A	113558442	4	1	117	1	0	0	0	0	0	1	0	0	12371	1763	61	5	2774	5	PPP1R3A	7	113558442	Nonsense_Mutation	SNP	T	TCGA-12-0821-01A-01W-0424-08	7897530	113558442	45580221	50	8010											
BRAF	673	broad.mit.edu	37	chr7	140453141	140453141	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctccatcgagatttcactgtAgctagaccaaaatcacctat	5	12	2	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr7:140453141A>T	uc003vwc.3	-	15	1855	c.1794T>A	c.(1792-1794)GCT>GCA	p.A598A		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	598	Protein kinase.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.A598_T599insV(6)|p.A598V(3)|p.D594_T599del(1)|p.A598T(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	ATTTCACTGTAGCTAGACCAA	0.368		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				T	140453141	T	T	140453141	2	4	117	1	0	0	0	0	0	0	0	1	1496	407	15	5		5	BRAF	7	140453141	Silent	SNP	A	TCGA-12-0821-01A-01W-0424-08	26894699	140453141	18685522	51	8011											
CSMD1	64478	broad.mit.edu	37	chr8	2832079	2832079	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggagtagtgcacgacggcGccataggtaaacagctctcc	12	12	1	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr8:2832079G>A	uc011kwk.1	-	56	9027	c.8637C>T	c.(8635-8637)GGC>GGT	p.G2879G	CSMD1_uc011kwj.1_Silent_p.G2208G|CSMD1_uc010lrg.2_Silent_p.G889G	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2879	Sushi 21.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCACGACGGCGCCATAGGTAA	0.557													A	2832079	A	A	2832079	2	1	117	1	0	0	0	0	0	0	0	1	3944	1074	38	1		1	CSMD1	8	2832079	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08		2832079	143531943	52	8012											
USP17L2	377630	broad.mit.edu	37	chr8	11995987	11995987	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtatgtcaggcactgcaGggaagcgttctcgtagcagg	15	8	2	0	rs3988861		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr8:11995987G>A	uc003wvc.1	-	1	283	c.283C>T	c.(283-285)CTG>TTG	p.L95L	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	95					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.L95L(1)		skin(2)|upper_aerodigestive_tract(1)	3						AGGCACTGCAGGGAAGCGTTC	0.567													A	11995987	A	A	11995987	2	1	117	1	0	0	0	0	0	0	0	1	17045	991	35	3		3	USP17L2	8	11995987	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08	9163908	11995987	134368035	53	8013											
SLC7A2	6542	broad.mit.edu	37	chr8	17422587	17422587	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagaaaaatctgccattcaaGcaaatgaccatcacccaaga	5	11	3	3			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr8:17422587G>A	uc011kyc.1	+	12	2078	c.1909G>A	c.(1909-1911)GCA>ACA	p.A637T	SLC7A2_uc011kyd.1_Missense_Mutation_p.A676T|SLC7A2_uc011kye.1_Missense_Mutation_p.A677T|SLC7A2_uc011kyf.1_Missense_Mutation_p.A637T	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	637	Cytoplasmic (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	TGCCATTCAAGCAAATGACCA	0.423													A	17422587	A	A	17422587	3	1	117	1	0	0	0	0	1	0	0	0	14697	971	34	3	2216	3	SLC7A2	8	17422587	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	5426600	17422587	128941435	54	8014											
DOK2	9046	broad.mit.edu	37	chr8	21771096	21771096	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatacaagaagccttgtttcActgccccgtctcccatcctc	6	16	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr8:21771096A>C	uc003wzy.1	-	1	110	c.17T>G	c.(16-18)GTG>GGG	p.V6G	DOK2_uc003wzx.1_Missense_Mutation_p.V6G|DOK2_uc003wzz.1_5'UTR|DOK2_uc010lth.1_5'UTR	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	6	PH.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GCCTTGTTTCACTGCCCCGTC	0.582													C	21771096	C	C	21771096	3	2	117	1	0	0	0	0	1	0	0	0	4697	159	6	5	1241	5	DOK2	8	21771096	Missense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08	4348509	21771096	124592926	55	8015											
ELP3	55140	broad.mit.edu	37	chr8	27954764	27954764	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccctgctgagctgatgatGctgactataggagatgttat	12	7	0	5			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr8:27954764G>A	uc003xgo.3	+	2	196	c.48G>A	c.(46-48)ATG>ATA	p.M16I	ELP3_uc003xgn.3_Missense_Mutation_p.M1I|ELP3_uc011laq.1_Intron|ELP3_uc011lar.1_5'UTR|ELP3_uc011las.1_Intron|ELP3_uc011lat.1_5'UTR	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	elongation protein 3 homolog	16					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding				0		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		AGCTGATGATGCTGACTATAG	0.368													A	27954764	A	A	27954764	3	1	117	1	0	0	0	0	1	0	0	0	5081	1319	46	3	54	3	ELP3	8	27954764	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	6183668	27954764	118409258	56	8016											
PCMTD1	115294	broad.mit.edu	37	chr8	52733124	52733124	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgattacccacaaatacgtaAgtgttaattctctgtttaac	5	8	1	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr8:52733124A>C	uc003xqx.3	-	6	1202	c.861T>G	c.(859-861)ACT>ACG	p.T287T	PCMTD1_uc011ldm.1_Silent_p.T157T|PCMTD1_uc003xqw.3_Silent_p.T287T|PCMTD1_uc011ldn.1_Silent_p.T99T|PCMTD1_uc010lya.2_Silent_p.T211T	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	287						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				CAAATACGTAAGTGTTAATTC	0.303													C	52733124	C	C	52733124	2	2	117	1	0	0	0	0	0	0	0	1	11586	59	3	5		5	PCMTD1	8	52733124	Silent	SNP	A	TCGA-12-0821-01A-01W-0424-08	24778360	52733124	93630898	57	8017											
ANGPT1	284	broad.mit.edu	37	chr8	108276567	108276567	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctgctgtcccagtgtgaccTtttaaatacaacctgaagtc	7	12	0	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr8:108276567T>C	uc003ymn.2	-	8	1686	c.1218A>G	c.(1216-1218)AAA>AAG	p.K406K	ANGPT1_uc011lhv.1_Silent_p.K206K|ANGPT1_uc003ymo.2_Silent_p.K405K	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	406	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			CAGTGTGACCTTTTAAATACA	0.393													C	108276567	C	C	108276567	2	2	117	1	0	0	0	0	0	0	0	1	610	1606	56	4		4	ANGPT1	8	108276567	Silent	SNP	T	TCGA-12-0821-01A-01W-0424-08	55543443	108276567	38087455	58	8018											
MAMDC2	256691	broad.mit.edu	37	chr9	72755159	72755159	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggttggacccgagtgaaaGtaaaaccaaacatgtatcgg	11	8	0	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr9:72755159G>A	uc004ahm.2	+	8	1710	c.1093G>A	c.(1093-1095)GTA>ATA	p.V365I	MAMDC2_uc004ahn.2_RNA	NM_153267	NP_694999	Q7Z304	MAMC2_HUMAN	MAM domain containing 2 precursor	365	MAM 3.					endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2						CCGAGTGAAAGTAAAACCAAA	0.458													A	72755159	A	A	72755159	3	1	117	1	0	0	0	0	1	0	0	0	9203	1029	36	3	1123	3	MAMDC2	9	72755159	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08		72755159	68458272	59	8019											
ATAD1	84896	broad.mit.edu	37	chr10	89550116	89550116	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tcaaacaaatgtttctttttGataggtaagatgactgtgtc	8	5	2	3			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr10:89550116G>A	uc001key.1	-	3	616	c.333C>T	c.(331-333)ATC>ATT	p.I111I	ATAD1_uc010qmr.1_Silent_p.I53I|ATAD1_uc009xth.1_RNA|ATAD1_uc001kez.1_Silent_p.I111I	NM_032810	NP_116199	Q8NBU5	ATAD1_HUMAN	ATPase family, AAA domain containing 1	111						peroxisome	ATP binding|nucleoside-triphosphatase activity			large_intestine(1)|ovary(1)	2		all_cancers(4;6.78e-12)|Prostate(4;3.56e-12)|all_epithelial(4;5.58e-09)|Melanoma(5;0.0273)|Breast(4;0.0424)|all_hematologic(4;0.0846)|Colorectal(252;0.207)|Glioma(4;0.217)|all_neural(4;0.224)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00131)|GBM - Glioblastoma multiforme(1;1.1e-32)|Lung(2;1.4e-05)|LUSC - Lung squamous cell carcinoma(2;2.69e-05)|Colorectal(12;7.09e-05)|COAD - Colon adenocarcinoma(12;0.000261)|STAD - Stomach adenocarcinoma(243;0.235)		GTTTCTTTTTGATAGGTAAGA	0.358													A	89550116	A	A	89550116	2	1	117	1	0	0	0	0	0	0	0	1	1070	1280	45	3		3	ATAD1	10	89550116	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08		89550116	45984631	60	8020											
MGEA5	10724	broad.mit.edu	37	chr10	103557792	103557792	+	Nonsense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atactcttgatatcccaaacAtaggagtacatgtcataaag	6	8	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr10:103557792A>C	uc001ktv.2	-	10	2372	c.1929T>G	c.(1927-1929)TAT>TAG	p.Y643*	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Nonsense_Mutation_p.Y590*|MGEA5_uc009xws.2_Nonsense_Mutation_p.Y590*|MGEA5_uc001ktw.2_Nonsense_Mutation_p.Y643*	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	643	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TATCCCAAACATAGGAGTACA	0.418													C	103557792	C	C	103557792	4	2	117	1	0	0	0	0	0	1	0	0	9555	224	8	5	849	5	MGEA5	10	103557792	Nonsense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08	14007676	103557792	31976955	61	8021											
OR51B6	390058	broad.mit.edu	37	chr11	5373426	5373426	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	catgggcattggttctggagGagaaagggccaaggccctca	15	9	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr11:5373426G>A	uc010qzb.1	+	1	689	c.689G>A	c.(688-690)GGA>GAA	p.G230E	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGTTCTGGAGGAGAAAGGGCC	0.418													A	5373426	A	A	5373426	3	1	117	1	0	0	0	0	1	0	0	0	11092	1174	41	3	691	3	OR51B6	11	5373426	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08		5373426	129633090	62	8022											
MICAL2	9645	broad.mit.edu	37	chr11	12225971	12225971	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgggagccaagaagttctatGggaagttctgtgctggctcc	14	8	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr11:12225971G>T	uc001mjz.2	+	4	727	c.439G>T	c.(439-441)GGG>TGG	p.G147W	MICAL2_uc010rch.1_Missense_Mutation_p.G147W|MICAL2_uc001mjy.2_Missense_Mutation_p.G147W|MICAL2_uc001mka.2_Missense_Mutation_p.G147W|MICAL2_uc010rci.1_Missense_Mutation_p.G147W|MICAL2_uc001mkb.2_Missense_Mutation_p.G147W|MICAL2_uc001mkc.2_Missense_Mutation_p.G147W	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	147						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		GAAGTTCTATGGGAAGTTCTG	0.552													T	12225971	T	T	12225971	3	4	117	1	0	0	0	0	1	0	0	0	9570	1348	47	5	445	5	MICAL2	11	12225971	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	6852545	12225971	122780545	63	8023											
KCNC1	3746	broad.mit.edu	37	chr11	17757795	17757795	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgcactgcccagccgacgtGtgcgggccgctctacgagga	14	15	1	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr11:17757795G>T	uc001mnk.3	+	1	301	c.246G>T	c.(244-246)GTG>GTT	p.V82V	KCNC1_uc009yhc.1_Silent_p.V82V	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	82	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						CAGCCGACGTGTGCGGGCCGC	0.677													T	17757795	T	T	17757795	2	4	117	1	0	0	0	0	0	0	0	1	8014	1364	48	5		5	KCNC1	11	17757795	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08	5531824	17757795	117248721	64	8024											
UEVLD	55293	broad.mit.edu	37	chr11	18554017	18554017	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaacttaaaaacacttcactAtttatatcataatatccctg	1	9	2	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr11:18554017A>G	uc001mot.2	-	12	1346	c.1266T>C	c.(1264-1266)AAT>AAC	p.N422N	UEVLD_uc001mou.2_3'UTR|UEVLD_uc010rde.1_Silent_p.N292N|UEVLD_uc010rdf.1_Silent_p.N400N|UEVLD_uc010rdg.1_Silent_p.N292N|UEVLD_uc001mov.2_3'UTR	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	422					cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						ACACTTCACTATTTATATCAT	0.313													G	18554017	G	G	18554017	2	3	117	1	0	0	0	0	0	0	0	1	16930	446	16	4		4	UEVLD	11	18554017	Silent	SNP	A	TCGA-12-0821-01A-01W-0424-08	796222	18554017	116452499	65	8025											
QSER1	79832	broad.mit.edu	37	chr11	32955067	32955067	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atcaagttattggggttgctCtgcaagcatcaaaaaaagaa	9	6	3	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr11:32955067C>G	uc001mty.2	+	4	2143	c.1876C>G	c.(1876-1878)CTG>GTG	p.L626V	QSER1_uc001mtz.1_Missense_Mutation_p.L387V|QSER1_uc001mua.2_Missense_Mutation_p.L131V	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	626										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					TGGGGTTGCTCTGCAAGCATC	0.378													G	32955067	G	G	32955067	3	3	117	1	0	0	0	0	1	0	0	0	12882	912	32	5	1882	5	QSER1	11	32955067	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	14401050	32955067	102051449	66	8026											
OR5A1	219982	broad.mit.edu	37	chr11	59211078	59211078	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacccagggcctctgtacacGcatggtggttggggcatatg	15	10	1	0	rs143071629	byFrequency	TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr11:59211078G>T	uc001nnx.1	+	1	437	c.437G>T	c.(436-438)CGC>CTC	p.R146L		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						CTCTGTACACGCATGGTGGTT	0.552													T	59211078	T	T	59211078	3	4	117	1	0	0	0	0	1	0	0	0	11139	1087	38	5	439	5	OR5A1	11	59211078	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	26256011	59211078	75795438	67	8027											
ODZ4	26011	broad.mit.edu	37	chr11	78380644	78380644	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccatcttgtattgcacgtcaCccagccgagtgatgcggtcg	11	13	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr11:78380644C>A	uc001ozl.3	-	32	7209	c.6746G>T	c.(6745-6747)GGT>GTT	p.G2249V	ODZ4_uc001ozk.3_Missense_Mutation_p.G474V|ODZ4_uc009yvb.1_Missense_Mutation_p.G833V	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2249	Extracellular (Potential).|YD 20.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TTGCACGTCACCCAGCCGAGT	0.562													A	78380644	A	A	78380644	3	1	117	1	0	0	0	0	1	0	0	0	10837	507	18	5	1575	5	ODZ4	11	78380644	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	19169566	78380644	56625872	68	8028											
APOA4	337	broad.mit.edu	37	chr11	116691955	116691955	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccctcaggttgccacgcacGtcctcggccaagggcgccag	12	18	1	0	rs146365840	byFrequency	TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr11:116691955G>A	uc001pps.1	-	3	923	c.819C>T	c.(817-819)GAC>GAT	p.D273D		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		TGCCACGCACGTCCTCGGCCA	0.672													A	116691955	A	A	116691955	2	1	117	1	0	0	0	0	0	0	0	1	783	1136	40	1		1	APOA4	11	116691955	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08	38311311	116691955	18314561	69	8029											
TWF1	5756	broad.mit.edu	37	chr12	44200088	44200100	+	Frame_Shift_Del	DEL	GCCAGCGGCCCCG	-	-													cggctccggcgctgagtgcaGccagcggccccggccggcgg							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr12:44200088_44200100delGCCAGCGGCCCCG	uc001rob.2	-	1	79_91	c.51_63delCGGGGCCGCTGGC	c.(49-63)GCCGGGGCCGCTGGCfs	p.A17fs	TWF1_uc001rnz.2_5'Flank|TWF1_uc001roa.2_Frame_Shift_Del_p.A17fs|TWF1_uc001roc.2_5'UTR	NM_002822	NP_002813	Q12792	TWF1_HUMAN	twinfilin 1	Error:Variant_position_missing_in_Q12792_after_alignment						actin cytoskeleton|cytoplasm	actin binding|protein tyrosine kinase activity			stomach(1)	1	all_cancers(12;0.00125)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.0474)		GCTGAGTGCAGCCAgcggccccggccggcggcc	0.54													-	44200100	-	-	44200088	7	5	117	1	0	1	0	1	0	0	0	0	16778	958	34	0	1127	0	TWF1	12	44200088	Frame_Shift_Del	DEL	GCCAGCGGCCCCG	TCGA-12-0821-01A-01W-0424-08		44200088	89651807	70	8030											
ZBTB39	9880	broad.mit.edu	37	chr12	57398062	57398062	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggacgtgaagggagcaggggTgtcatggtcttctgtctttg	17	6	4	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr12:57398062T>G	uc001sml.1	-	2	726	c.640A>C	c.(640-642)ACC>CCC	p.T214P	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						GGAGCAGGGGTGTCATGGTCT	0.572													G	57398062	G	G	57398062	3	3	117	1	0	0	0	0	1	0	0	0	17537	1696	59	5	1502	5	ZBTB39	12	57398062	Missense_Mutation	SNP	T	TCGA-12-0821-01A-01W-0424-08	13197974	57398062	76453833	71	8031											
LRRIQ1	84125	broad.mit.edu	37	chr12	85450302	85450302	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagcagaaaataatcaaagaTaatcagcagaaaaagataca	7	5	2	4			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr12:85450302T>C	uc001tac.2	+	8	1842	c.1731T>C	c.(1729-1731)GAT>GAC	p.D577D	LRRIQ1_uc001tab.1_Silent_p.D577D|LRRIQ1_uc001taa.1_Silent_p.D552D	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	577										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TAATCAAAGATAATCAGCAGA	0.289													C	85450302	C	C	85450302	2	2	117	1	0	0	0	0	0	0	0	1	9029	1403	49	4		4	LRRIQ1	12	85450302	Silent	SNP	T	TCGA-12-0821-01A-01W-0424-08	28052240	85450302	48401593	72	8032											
WSB2	55884	broad.mit.edu	37	chr12	118490112	118490113	+	Splice_Site	INS	-	A	A													gccccagtacgagaatacttINSacaactgctcctccaacggc							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr12:118490112_118490113insA	uc001twr.2	-	2	280	c.182_splice	c.e2+1	p.F61_splice	WSB2_uc010sza.1_Intron|WSB2_uc010szb.1_Splice_Site|WSB2_uc009zws.1_Splice_Site_p.F61_splice	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2						intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGAGAATACTTACAACTGCTCC	0.55													A	118490113	A	A	118490112	8	5	117	1	0	1	1	0	0	0	1	0	17402	1769	61	0		0	WSB2	12	118490112	Splice_Site	INS	-	TCGA-12-0821-01A-01W-0424-08	33039810	118490112	15361783	73	8033											
ATP8A2	51761	broad.mit.edu	37	chr13	26411335	26411335	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gccgcccttcactctgggaaTctttgagaggtcttgcactc	10	13	4	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr13:26411335T>A	uc001uqk.2	+	29	2931	c.2789T>A	c.(2788-2790)ATC>AAC	p.I930N	ATP8A2_uc010tdi.1_Missense_Mutation_p.I865N|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.I480N	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	890	Helical; (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ACTCTGGGAATCTTTGAGAGG	0.502													A	26411335	A	A	26411335	3	1	117	1	0	0	0	0	1	0	0	0	1193	1435	50	5	2903	5	ATP8A2	13	26411335	Missense_Mutation	SNP	T	TCGA-12-0821-01A-01W-0424-08		26411335	88758543	74	8034											
WASF3	10810	broad.mit.edu	37	chr13	27256966	27256967	+	Frame_Shift_Ins	INS	-	C	C													cacccccgggcccaccacctINScccccgccaggccctcctgg							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr13:27256966_27256967insC	uc001uqv.2	+	9	1431_1432	c.1206_1207insC	c.(1204-1209)CCTCCCfs	p.P402fs	WASF3_uc001uqw.2_Frame_Shift_Ins_p.P399fs	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	402_403	Poly-Pro.				actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		GCCCACCACCTCCCCCGCCAGG	0.708													C	27256967	C	C	27256966	7	5	117	1	0	1	1	0	0	0	0	0	17251	1538	54	0	1232	0	WASF3	13	27256966	Frame_Shift_Ins	INS	-	TCGA-12-0821-01A-01W-0424-08	845631	27256966	87912912	75	8035											
FLT1	2321	broad.mit.edu	37	chr13	28880897	28880897	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggccaacagagtgctgctgtCgccctggtagtcctaggggg	16	11	0	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr13:28880897C>T	uc001usb.3	-	29	4018	c.3733G>A	c.(3733-3735)GAC>AAC	p.D1245N	FLT1_uc010aap.2_Missense_Mutation_p.D250N|FLT1_uc010aaq.2_Missense_Mutation_p.D370N|FLT1_uc001usa.3_Missense_Mutation_p.D463N	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1245	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GTGCTGCTGTCGCCCTGGTAG	0.552													T	28880897	T	T	28880897	3	4	117	1	0	0	0	0	1	0	0	0	5941	884	31	2	291	2	FLT1	13	28880897	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	1623931	28880897	86288981	76	8036											
FLT1	2321	broad.mit.edu	37	chr13	29004213	29004213	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttccggcgagggaaatgcCttcactttcatagagagccg	11	11	2	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr13:29004213C>T	uc001usb.3	-	8	1365	c.1080G>A	c.(1078-1080)AAG>AAA	p.K360K	FLT1_uc010aar.1_Silent_p.K360K|FLT1_uc001usc.3_Silent_p.K360K|FLT1_uc010tdp.1_Silent_p.K360K	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	360	Ig-like C2-type 4.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AGGGAAATGCCTTCACTTTCA	0.443													T	29004213	T	T	29004213	2	4	117	1	0	0	0	0	0	0	0	1	5941	680	24	3		3	FLT1	13	29004213	Silent	SNP	C	TCGA-12-0821-01A-01W-0424-08	123316	29004213	86165665	77	8037											
DOCK9	23348	broad.mit.edu	37	chr13	99549805	99549805	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcttattgctgtcttgcctgTagatggcagaaaatctggca	11	8	2	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr13:99549805T>A	uc001vnt.2	-	15	1704	c.1649A>T	c.(1648-1650)TAC>TTC	p.Y550F	DOCK9_uc001vnw.2_Missense_Mutation_p.Y549F|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.Y550F|DOCK9_uc010tis.1_Missense_Mutation_p.Y549F|DOCK9_uc010tit.1_Missense_Mutation_p.Y550F|DOCK9_uc010afu.1_Missense_Mutation_p.Y365F	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	550					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GTCTTGCCTGTAGATGGCAGA	0.383													A	99549805	A	A	99549805	3	1	117	1	0	0	0	0	1	0	0	0	4694	1638	57	5	4789	5	DOCK9	13	99549805	Missense_Mutation	SNP	T	TCGA-12-0821-01A-01W-0424-08	70545592	99549805	15620073	78	8038											
COL4A2	1284	broad.mit.edu	37	chr13	111132630	111132630	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggccctgtgggcatgaaagGtctctctggtgacagaggag	16	8	2	3			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr13:111132630G>T	uc001vqx.2	+	31	2940	c.2651G>T	c.(2650-2652)GGT>GTT	p.G884V		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	884	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGCATGAAAGGTCTCTCTGGT	0.582													T	111132630	T	T	111132630	3	4	117	1	0	0	0	0	1	0	0	0	3690	1261	44	5	2769	5	COL4A2	13	111132630	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	11582825	111132630	4037248	79	8039											
ZFYVE26	23503	broad.mit.edu	37	chr14	68247033	68247033	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaaggtctgccagtcacaCcacactgggggagactgcaa	11	13	3	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr14:68247033C>T	uc001xka.2	-	23	4738	c.4599G>A	c.(4597-4599)TGG>TGA	p.W1533*	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Nonsense_Mutation_p.W1533*	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1533					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCCAGTCACACCACACTGGGG	0.502													T	68247033	T	T	68247033	4	4	117	1	0	0	0	0	0	1	0	0	17665	508	18	3	3100	3	ZFYVE26	14	68247033	Nonsense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08		68247033	39102507	80	8040											
NDUFB1	4707	broad.mit.edu	37	chr14	92588104	92588104	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgcccgcacggagcagagggGtgacgccagcaaatcatact	13	13	1	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr14:92588104G>C	uc001yaf.2	-	1	50	c.18C>G	c.(16-18)CAC>CAG	p.H6Q	NDUFB1_uc001yag.1_RNA|CPSF2_uc001yah.1_5'Flank	NM_004545	NP_004536	O75438	NDUB1_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	14	Helical; (Potential).				mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.205)	NADH(DB00157)	GAGCAGAGGGGTGACGCCAGC	0.517													C	92588104	C	C	92588104	3	2	117	1	0	0	0	0	1	0	0	0	10278	1252	44	5	311	5	NDUFB1	14	92588104	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	24341071	92588104	14761436	81	8041											
SERPINA1	5265	broad.mit.edu	37	chr14	94849084	94849084	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	agttgacagtgaaggcttctGagtggtacaactttttaaca	10	6	1	3			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr14:94849084G>T	uc001ycx.3	-	2	752	c.491C>A	c.(490-492)TCA>TAA	p.S164*	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Nonsense_Mutation_p.S164*|SERPINA1_uc010aux.2_Nonsense_Mutation_p.S164*|SERPINA1_uc001ycy.3_Nonsense_Mutation_p.S164*|SERPINA1_uc010auy.2_Nonsense_Mutation_p.S164*|SERPINA1_uc001ycz.3_Nonsense_Mutation_p.S164*|SERPINA1_uc010auz.2_Nonsense_Mutation_p.S164*|SERPINA1_uc010ava.2_Nonsense_Mutation_p.S164*|SERPINA1_uc001ydb.3_Nonsense_Mutation_p.S164*|SERPINA1_uc010avb.2_Nonsense_Mutation_p.S164*|SERPINA1_uc001ydc.3_Nonsense_Mutation_p.S164*|SERPINA1_uc001yda.1_Nonsense_Mutation_p.S164*	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	164					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	GAAGGCTTCTGAGTGGTACAA	0.502									Alpha-1-Antitrypsin_Deficiency				T	94849084	T	T	94849084	4	4	117	1	0	0	0	0	0	1	0	0	14086	1294	45	5	781	5	SERPINA1	14	94849084	Nonsense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	2260980	94849084	12500456	82	8042											
LCMT2	9836	broad.mit.edu	37	chr15	43622424	43622425	+	Frame_Shift_Del	DEL	GA	-	-													agcgagtcgaagccagcgccGagagacaagatctgcgcgcg							TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr15:43622424_43622425delGA	uc001zrg.2	-	1	467_468	c.263_264delTC	c.(262-264)CTCfs	p.L88fs	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	88					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	AGCCAGCGCCGAGAGACAAGAT	0.668													-	43622425	-	-	43622424	7	5	117	1	0	1	0	1	0	0	0	0	8679	1045	37	0	1800	0	LCMT2	15	43622424	Frame_Shift_Del	DEL	GA	TCGA-12-0821-01A-01W-0424-08		43622424	58908968	83	8043											
UNC13C	440279	broad.mit.edu	37	chr15	54624283	54624283	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggaccagttacataactctTtgaggattgatctgtcaaag	9	7	3	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr15:54624283T>A	uc002ack.2	+	13	4468	c.4468T>A	c.(4468-4470)TTG>ATG	p.L1490M	UNC13C_uc002acl.2_Missense_Mutation_p.L320M	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1490					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ACATAACTCTTTGAGGATTGA	0.313													A	54624283	A	A	54624283	3	1	117	1	0	0	0	0	1	0	0	0	16983	1838	64	5	4518	5	UNC13C	15	54624283	Missense_Mutation	SNP	T	TCGA-12-0821-01A-01W-0424-08	11001859	54624283	47907109	84	8044											
MCTP2	55784	broad.mit.edu	37	chr15	94899492	94899492	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaagcatgacagagatgtttGtccagttaaaactgggagat	12	5	0	3			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr15:94899492G>T	uc002btj.2	+	8	1197	c.1132G>T	c.(1132-1134)GTC>TTC	p.V378F	MCTP2_uc010urg.1_Missense_Mutation_p.V378F|MCTP2_uc002bti.2_Missense_Mutation_p.V378F|MCTP2_uc010boj.2_Missense_Mutation_p.V107F|MCTP2_uc010bok.2_Missense_Mutation_p.V378F|MCTP2_uc002btk.3_5'UTR|MCTP2_uc002btl.2_5'UTR	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	378	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AGAGATGTTTGTCCAGTTAAA	0.348													T	94899492	T	T	94899492	3	4	117	1	0	0	0	0	1	0	0	0	9401	1377	48	5	1162	5	MCTP2	15	94899492	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	40275209	94899492	7631900	85	8045											
CLEC16A	23274	broad.mit.edu	37	chr16	11118694	11118694	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccagacccttcctggatatgGtgtaccacgcgctggacagc	11	14	0	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr16:11118694G>C	uc002dao.2	+	13	1683	c.1453G>C	c.(1453-1455)GTG>CTG	p.V485L	CLEC16A_uc002dan.3_Missense_Mutation_p.V467L	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	485								p.0?(1)		ovary(1)|central_nervous_system(1)	2						CCTGGATATGGTGTACCACGC	0.547													C	11118694	C	C	11118694	3	2	117	1	0	0	0	0	1	0	0	0	3500	1261	44	5	1499	5	CLEC16A	16	11118694	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08		11118694	79236059	86	8046											
CHST4	10164	broad.mit.edu	37	chr16	71570968	71570968	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctttcagtgggagaacagcCgggccctgtgttctgcacct	12	12	3	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr16:71570968C>T	uc002fan.2	+	2	569	c.388C>T	c.(388-390)CGG>TGG	p.R130W	CHST4_uc002fao.2_Missense_Mutation_p.R130W	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	130	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						GGAGAACAGCCGGGCCCTGTG	0.572													T	71570968	T	T	71570968	3	4	117	1	0	0	0	0	1	0	0	0	3406	643	23	2	390	2	CHST4	16	71570968	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	60452274	71570968	18783785	87	8047											
ZCCHC14	23174	broad.mit.edu	37	chr16	87448975	87448975	+	Splice_Site	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttcagtaaggctcaaaaacTttcacagaaaaaacaaatta	4	8	3	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr16:87448975T>G	uc002fjz.1	-	9	1000	c.973_splice	c.e9-1	p.F325_splice	ZCCHC14_uc002fka.1_Splice_Site|ZCCHC14_uc002fkb.2_Splice_Site_p.F101_splice	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14						cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GCTCAAAAACTTTCACAGAAA	0.398													G	87448975	G	G	87448975	5	3	117	1	0	0	0	0	0	0	1	0	17580	1623	56	5	1898	5	ZCCHC14	16	87448975	Splice_Site	SNP	T	TCGA-12-0821-01A-01W-0424-08	15878007	87448975	2905778	88	8048											
ALOX15	246	broad.mit.edu	37	chr17	4542381	4542381	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctctcttccagctcttcttcCcggtgtttctggaacaggcc	8	15	4	0	rs146477215		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr17:4542381C>G	uc002fyh.2	-	3	398	c.384G>C	c.(382-384)CGG>CGC	p.R128R	ALOX15_uc010vsd.1_Silent_p.R89R|ALOX15_uc010vse.1_Silent_p.R150R	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	128	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity	p.R128R(1)		skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	GCTCTTCTTCCCGGTGTTTCT	0.577													G	4542381	G	G	4542381	2	3	117	1	0	0	0	0	0	0	0	1	538	610	22	5		5	ALOX15	17	4542381	Silent	SNP	C	TCGA-12-0821-01A-01W-0424-08		4542381	76652829	89	8049											
DAPK3	1613	broad.mit.edu	37	chr19	3961153	3961153	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccaggaacggggatgcaccGctcaggctgcgagacaggcg	16	13	1	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr19:3961153G>A	uc002lzc.1	-	6	729	c.636C>T	c.(634-636)AGC>AGT	p.S212S	DAPK3_uc002lzb.1_5'UTR|DAPK3_uc002lzd.1_Silent_p.S212S	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	212	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGATGCACCGCTCAGGCTGC	0.662													A	3961153	A	A	3961153	2	1	117	1	0	0	0	0	0	0	0	1	4237	1078	38	1		1	DAPK3	19	3961153	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08		3961153	55167830	90	8050											
TSPAN16	26526	broad.mit.edu	37	chr19	11411902	11411902	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatgtggccttggaacacaCcttcgtgaccctgaggaaga	12	10	0	4			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr19:11411902C>T	uc002mqv.1	+	4	518	c.368C>T	c.(367-369)ACC>ATC	p.T123I	TSPAN16_uc002mqu.1_RNA|uc002mqw.1_RNA	NM_012466	NP_036598	Q9UKR8	TSN16_HUMAN	transmembrane 4 superfamily member 16	123	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						TTGGAACACACCTTCGTGACC	0.498													T	11411902	T	T	11411902	3	4	117	1	0	0	0	0	1	0	0	0	16637	507	18	3	382	3	TSPAN16	19	11411902	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08	7450749	11411902	47717081	91	8051											
CYP4F12	66002	broad.mit.edu	37	chr19	15791069	15791069	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcagctgccattgcacccaAggataatctcttcatcaggt	8	12	4	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr19:15791069A>G	uc002nbl.2	+	4	420	c.359A>G	c.(358-360)AAG>AGG	p.K120R	CYP4F12_uc010xoo.1_Missense_Mutation_p.K120R|CYP4F12_uc010xop.1_Missense_Mutation_p.K120R	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					ATTGCACCCAAGGATAATCTC	0.562													G	15791069	G	G	15791069	3	3	117	1	0	0	0	0	1	0	0	0	4187	72	3	4	369	4	CYP4F12	19	15791069	Missense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08	4379167	15791069	43337914	92	8052											
NDUFA13	51079	broad.mit.edu	37	chr19	19638108	19638108	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcgcctacaaatcgaggaCttcgaggctcgcatcgcgct	12	13	0	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr19:19638108C>T	uc010xqy.1	+	3	700	c.441C>T	c.(439-441)GAC>GAT	p.D147D	NDUFA13_uc002nms.2_Silent_p.D147D|NDUFA13_uc010xqx.1_Silent_p.D147D|YJEFN3_uc002nmt.1_5'Flank|YJEFN3_uc010ecf.1_5'Flank|YJEFN3_uc002nmu.1_5'Flank	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	64					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	AAATCGAGGACTTCGAGGCTC	0.592													T	19638108	T	T	19638108	2	4	117	1	0	0	0	0	0	0	0	1	10263	564	20	3		3	NDUFA13	19	19638108	Silent	SNP	C	TCGA-12-0821-01A-01W-0424-08	3847039	19638108	39490875	93	8053											
ZNF536	9745	broad.mit.edu	37	chr19	30934639	30934639	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccatccccggcccaaccccgAggagaagccccccgcatccc	8	23	0	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr19:30934639A>G	uc002nsu.1	+	2	308	c.170A>G	c.(169-171)GAG>GGG	p.E57G	ZNF536_uc010edd.1_Missense_Mutation_p.E57G	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCCAACCCCGAGGAGAAGCCC	0.677													G	30934639	G	G	30934639	3	3	117	1	0	0	0	0	1	0	0	0	17971	304	11	4	172	4	ZNF536	19	30934639	Missense_Mutation	SNP	A	TCGA-12-0821-01A-01W-0424-08	11296531	30934639	28194344	94	8054											
GPR4	2828	broad.mit.edu	37	chr19	46094672	46094672	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctcgtcatggaacaggggCgccgagttggcgcccagctc	15	13	1	0			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr19:46094672C>T	uc002pcm.2	-	2	1398	c.453G>A	c.(451-453)GCG>GCA	p.A151A	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	151	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		GGAACAGGGGCGCCGAGTTGG	0.657													T	46094672	T	T	46094672	2	4	117	1	0	0	0	0	0	0	0	1	6694	755	27	1		1	GPR4	19	46094672	Silent	SNP	C	TCGA-12-0821-01A-01W-0424-08	15160033	46094672	13034311	95	8055											
ZNF814	730051	broad.mit.edu	37	chr19	58385050	58385050	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ataagatctttctctagggtGaactcgctgatgtagaatga	10	6	2	5			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr19:58385050G>A	uc002qqo.2	-	3	1980	c.1708C>T	c.(1708-1710)CAC>TAC	p.H570Y	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	570	C2H2-type 13.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TCTCTAGGGTGAACTCGCTGA	0.468													A	58385050	A	A	58385050	3	1	117	1	0	0	0	0	1	0	0	0	18173	1290	45	3	863	3	ZNF814	19	58385050	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	12290378	58385050	743933	96	8056											
SRMS	6725	broad.mit.edu	37	chr20	62172863	62172863	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccacgagcacgttccgggCggccaagtcccggtgcacaa	13	15	0	0	rs61740255		TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr20:62172863C>T	uc002yfi.1	-	6	1098	c.1057G>A	c.(1057-1059)GCC>ACC	p.A353T		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	353	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			ACGTTCCGGGCGGCCAAGTCC	0.706													T	62172863	T	T	62172863	3	4	117	1	0	0	0	0	1	0	0	0	15151	768	27	1	421	1	SRMS	20	62172863	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08		62172863	852657	97	8057											
ZNRF3	84133	broad.mit.edu	37	chr22	29440867	29440867	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaaaatcaagctgaagcagCgacgcagtcaggtagtgcct	11	10	3	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr22:29440867C>T	uc003aeg.2	+	5	598	c.433C>T	c.(433-435)CGA>TGA	p.R145*	ZNRF3_uc003aeh.1_Nonsense_Mutation_p.R145*	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	245	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						GCTGAAGCAGCGACGCAGTCA	0.512													T	29440867	T	T	29440867	4	4	117	1	0	0	0	0	0	1	0	0	18210	760	27	1	447	1	ZNRF3	22	29440867	Nonsense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08		29440867	21863699	98	8058											
GCAT	23464	broad.mit.edu	37	chr22	38211771	38211771	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacctgctgtcgttggctgcGcctccaaggccctagatctg	11	15	1	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chr22:38211771G>A	uc003atz.2	+	7	936	c.916G>A	c.(916-918)GCC>ACC	p.A306T	GCAT_uc003aua.1_Missense_Mutation_p.A332T	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	306					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CGTTGGCTGCGCCTCCAAGGC	0.657													A	38211771	A	A	38211771	3	1	117	1	0	0	0	0	1	0	0	0	6284	1087	38	1	1020	1	GCAT	22	38211771	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	8770904	38211771	13092795	99	8059											
NXF3	56000	broad.mit.edu	37	chrX	102339283	102339283	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cactcactgtgatcttgaacCagctccctaaggtcccatcc	6	16	2	2			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chrX:102339283C>G	uc004eju.2	-	3	409	c.338G>C	c.(337-339)TGG>TCG	p.W113S	NXF3_uc010noi.1_5'Flank|NXF3_uc011mrw.1_Missense_Mutation_p.W113S|NXF3_uc011mrx.1_Missense_Mutation_p.W24S	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	113	RRM.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						GATCTTGAACCAGCTCCCTAA	0.463													G	102339283	G	G	102339283	3	3	117	1	0	0	0	0	1	0	0	0	10785	595	21	5	1325	5	NXF3	23	102339283	Missense_Mutation	SNP	C	TCGA-12-0821-01A-01W-0424-08		102339283	52931277	100	8060											
WDR44	54521	broad.mit.edu	37	chrX	117527112	117527112	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaagaagcctgttccagcacGcccacctcctccaactaatt	5	16	0	1			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chrX:117527112G>A	uc004eqn.2	+	4	1129	c.704G>A	c.(703-705)CGC>CAC	p.R235H	WDR44_uc004eqo.2_Missense_Mutation_p.R235H|WDR44_uc011mtr.1_Missense_Mutation_p.R210H|WDR44_uc010nqi.2_5'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	235	Pro-rich.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						GTTCCAGCACGCCCACCTCCT	0.522													A	117527112	A	A	117527112	3	1	117	1	0	0	0	0	1	0	0	0	17293	1087	38	1	718	1	WDR44	23	117527112	Missense_Mutation	SNP	G	TCGA-12-0821-01A-01W-0424-08	15187829	117527112	37743448	101	8061											
STAG2	10735	broad.mit.edu	37	chrX	123176497	123176497	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gactgaagaattcgatgaggTaacttactaccttaagtgtt	9	6	0	3			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chrX:123176497T>C	uc004etz.3	+	6	801	c.462_splice	c.e6+2	p.E154_splice	STAG2_uc004eua.2_Splice_Site_p.E154_splice|STAG2_uc004eub.2_Splice_Site_p.E154_splice|STAG2_uc004euc.2_Splice_Site_p.E154_splice|STAG2_uc004eud.2_Splice_Site_p.E154_splice|STAG2_uc004eue.2_Splice_Site_p.E154_splice	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b						cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TTCGATGAGGTAACTTACTAC	0.274													C	123176497	C	C	123176497	5	2	117	1	0	0	0	0	0	0	1	0	15242	1652	57	4	482	4	STAG2	23	123176497	Splice_Site	SNP	T	TCGA-12-0821-01A-01W-0424-08	5649385	123176497	32094063	102	8062											
GPC4	2239	broad.mit.edu	37	chrX	132458560	132458560	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttttcaagtagttctttgaaGaattctgaaaccaacaccaa	5	8	3	3			TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chrX:132458560G>A	uc004exc.1	-	3	536	c.324C>T	c.(322-324)TTC>TTT	p.F108F	GPC4_uc011mvg.1_Silent_p.F38F	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	108					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					GTTCTTTGAAGAATTCTGAAA	0.284													A	132458560	A	A	132458560	2	1	117	1	0	0	0	0	0	0	0	1	6600	933	33	3		3	GPC4	23	132458560	Silent	SNP	G	TCGA-12-0821-01A-01W-0424-08	9282063	132458560	22812000	103	8063											
SPANXC	64663	broad.mit.edu	37	chrX	140335819	140335820	+	Frame_Shift_Ins	INS	-	T	T													cgaggactcagatgttttcaINStttttttaggagcaggttgc					rs57835830	byFrequency	TCGA-12-0821-01A-01W-0424-08	TCGA-12-0821-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	357e3a3c-cceb-4b38-bc35-6fe8f5be5ac8	b8bd0920-2514-4261-a8fc-0130a4fd6970	g.chrX:140335819_140335820insT	uc004fbk.2	-	2	180_181	c.124_125insA	c.(124-126)ATGfs	p.M42fs	SPANXC_uc004fbl.2_RNA	NM_022661	NP_073152	Q9NY87	SPNXC_HUMAN	sperm protein associated with the nucleus, X	42	Nuclear localization signal (Potential).					cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					AGATGTTTTCATTTTTTTAGGA	0.5													T	140335820	T	T	140335819	7	5	117	1	0	1	1	0	0	0	0	0	14987	217	8	0	172	0	SPANXC	23	140335819	Frame_Shift_Ins	INS	-	TCGA-12-0821-01A-01W-0424-08	7877259	140335819	14934741	104	8064											
UBR4	23352	broad.mit.edu	37	chr1	19484449	19484449	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctccactgtaattcatccGcacattctcaaaggcacctt	5	14	3	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr1:19484449G>A	uc001bbi.2	-	40	5624	c.5620C>T	c.(5620-5622)CGG>TGG	p.R1874W	UBR4_uc001bbl.1_5'Flank|UBR4_uc001bbm.1_Missense_Mutation_p.R1085W	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1874					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TAATTCATCCGCACATTCTCA	0.537													A	19484449	A	A	19484449	3	1	118	1	0	0	0	0	1	0	0	0	16901	1086	38	1	10199	1	UBR4	1	19484449	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08		19484449	229766172	1	8065											
C1orf173	127254	broad.mit.edu	37	chr1	75038513	75038513	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctctctctttgatgctgtgtCctccatgggtcctgtgtcct	9	13	2	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr1:75038513C>G	uc001dgg.2	-	14	3100	c.2881G>C	c.(2881-2883)GAC>CAC	p.D961H		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	961	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GATGCTGTGTCCTCCATGGGT	0.522													G	75038513	G	G	75038513	3	3	118	1	0	0	0	0	1	0	0	0	2014	855	30	5	1715	5	C1orf173	1	75038513	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	55554064	75038513	174212108	2	8066											
C1orf173	127254	broad.mit.edu	37	chr1	75055650	75055650	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagaagatgaccttctggcaCtttcatctgtgctgctgtca	10	10	4	3			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr1:75055650C>A	uc001dgg.2	-	12	2060	c.1841G>T	c.(1840-1842)AGT>ATT	p.S614I	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.S408I	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	614	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTTCTGGCACTTTCATCTGT	0.448													A	75055650	A	A	75055650	3	1	118	1	0	0	0	0	1	0	0	0	2014	565	20	5	2763	5	C1orf173	1	75055650	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	17137	75055650	174194971	3	8067											
NGF	4803	broad.mit.edu	37	chr1	115828831	115828831	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtacaatatgagttccagtGctttgagtcaatgccccggc	11	10	1	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr1:115828831G>A	uc001efu.1	-	3	755	c.586C>T	c.(586-588)CAC>TAC	p.H196Y		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	196					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	GAGTTCCAGTGCTTTGAGTCA	0.517													A	115828831	A	A	115828831	3	1	118	1	0	0	0	0	1	0	0	0	10395	1319	46	3	143	3	NGF	1	115828831	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	40773181	115828831	133421790	4	8068											
SPTA1	6708	broad.mit.edu	37	chr1	158641934	158641934	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgctcatactgacgatgaCgctcgtcccacagttccagc	8	15	1	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr1:158641934C>T	uc001fst.1	-	11	1602	c.1403G>A	c.(1402-1404)CGT>CAT	p.R468H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	468	Spectrin 5.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTGACGATGACGCTCGTCCCA	0.438													T	158641934	T	T	158641934	3	4	118	1	0	0	0	0	1	0	0	0	15115	536	19	1	6024	1	SPTA1	1	158641934	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	42813103	158641934	90608687	5	8069											
FAM5C	339479	broad.mit.edu	37	chr1	190067205	190067205	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggcaatttggcattaaaCgcctgcagagcagattggat	11	7	0	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr1:190067205C>T	uc001gse.1	-	8	2476	c.2244G>A	c.(2242-2244)GCG>GCA	p.A748A	FAM5C_uc010pot.1_Silent_p.A646A	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	748						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGGCATTAAACGCCTGCAGAG	0.423													T	190067205	T	T	190067205	2	4	118	1	0	0	0	0	0	0	0	1	5594	523	19	1		1	FAM5C	1	190067205	Silent	SNP	C	TCGA-12-1597-01B-01D-1495-08	31425271	190067205	59183416	6	8070											
OBSCN	84033	broad.mit.edu	37	chr1	228466482	228466482	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcaggtgtcccgggccagcGcccaggtgcggtggttcaag	17	12	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr1:228466482G>A	uc009xez.1	+	26	6996	c.6952G>A	c.(6952-6954)GCC>ACC	p.A2318T	OBSCN_uc001hsn.2_Missense_Mutation_p.A2318T|OBSCN_uc001hsp.1_Missense_Mutation_p.A17T|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2318	Ig-like 23.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCGGGCCAGCGCCCAGGTGCG	0.637													A	228466482	A	A	228466482	3	1	118	1	0	0	0	0	1	0	0	0	10812	1087	38	1	7050	1	OBSCN	1	228466482	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	38399277	228466482	20784139	7	8071											
OR2M4	26245	broad.mit.edu	37	chr1	248403138	248403138	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agtgttcagggcactacagaAggtactgaagaaaagaaagt	12	5	1	4			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr1:248403138A>T	uc010pzh.1	+	1	908	c.908A>T	c.(907-909)AAG>ATG	p.K303M		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	303	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCACTACAGAAGGTACTGAAG	0.398													T	248403138	T	T	248403138	3	4	118	1	0	0	0	0	1	0	0	0	11012	72	3	5	910	5	OR2M4	1	248403138	Missense_Mutation	SNP	A	TCGA-12-1597-01B-01D-1495-08	19936656	248403138	847483	8	8072											
MYT1L	23040	broad.mit.edu	37	chr2	1926184	1926184	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcctcccagcttccatggCcatcttctccctcatggcct	5	20	3	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:1926184C>T	uc002qxe.2	-	10	2184	c.1357G>A	c.(1357-1359)GCC>ACC	p.A453T	MYT1L_uc002qxd.2_Missense_Mutation_p.A453T|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	453					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GCTTCCATGGCCATCTTCTCC	0.537													T	1926184	T	T	1926184	3	4	118	1	0	0	0	0	1	0	0	0	10107	739	26	3	2261	3	MYT1L	2	1926184	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		1926184	241273189	9	8073											
FAM98A	25940	broad.mit.edu	37	chr2	33810356	33810356	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatgacctcctcgtcctccGtatgaggaatgttcatagcc	8	13	2	2	rs34080556		TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:33810356G>A	uc002rpa.1	-	8	1118	c.1044C>T	c.(1042-1044)TAC>TAT	p.Y348Y	FAM98A_uc010yne.1_Silent_p.Y153Y|FAM98A_uc010ynd.1_Silent_p.Y179Y|FAM98A_uc002roz.1_Silent_p.Y186Y	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	349	Gly-rich.									ovary(1)	1	all_hematologic(175;0.115)					CTCGTCCTCCGTATGAGGAAT	0.597													A	33810356	A	A	33810356	2	1	118	1	0	0	0	0	0	0	0	1	5656	1140	40	1		1	FAM98A	2	33810356	Silent	SNP	G	TCGA-12-1597-01B-01D-1495-08	31884172	33810356	209389017	10	8074											
SNRNP200	23020	broad.mit.edu	37	chr2	96957584	96957584	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttctaggcacatgtcccGgatggccctggctgtctttc	10	13	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:96957584G>A	uc002svu.2	-	17	2301	c.2215C>T	c.(2215-2217)CGG>TGG	p.R739W	SNRNP200_uc002svw.1_5'Flank	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	739	Helicase C-terminal 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.R739W(1)		ovary(5)|skin(4)|large_intestine(1)	10						CACATGTCCCGGATGGCCCTG	0.557													A	96957584	A	A	96957584	3	1	118	1	0	0	0	0	1	0	0	0	14852	1115	39	2	4311	2	SNRNP200	2	96957584	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	63147228	96957584	146241789	11	8075											
ST6GAL2	84620	broad.mit.edu	37	chr2	107460248	107460248	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagggctcatgtgcggcgccCatgatggcccgctgcttccc	14	15	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:107460248C>T	uc002tdq.2	-	2	305	c.186G>A	c.(184-186)ATG>ATA	p.M62I	ST6GAL2_uc002tdr.2_Missense_Mutation_p.M62I|ST6GAL2_uc002tds.3_Missense_Mutation_p.M62I	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	62	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GTGCGGCGCCCATGATGGCCC	0.711													T	107460248	T	T	107460248	3	4	118	1	0	0	0	0	1	0	0	0	15221	594	21	3	1510	3	ST6GAL2	2	107460248	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	10502664	107460248	135739125	12	8076											
TTN	7273	broad.mit.edu	37	chr2	179454762	179454762	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtctgtcaaggacgttaaCgatggctgaaccttgggcat	13	8	2	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:179454762C>T	uc010zfg.1	-	253	54210	c.53986G>A	c.(53986-53988)GTT>ATT	p.V17996I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V11691I|TTN_uc010zfi.1_Missense_Mutation_p.V11624I|TTN_uc010zfj.1_Missense_Mutation_p.V11499I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18923							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGACGTTAACGATGGCTGAA	0.428													T	179454762	T	T	179454762	3	4	118	1	0	0	0	0	1	0	0	0	16732	536	19	1	46525	1	TTN	2	179454762	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	71994514	179454762	63744611	13	8077											
TTN	7273	broad.mit.edu	37	chr2	179584862	179584862	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggtattttcactctctctgAtgacttcacctctatctttc	4	12	6	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:179584862A>G	uc010zfg.1	-	78	19999	c.19775T>C	c.(19774-19776)ATC>ACC	p.I6592T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I3253T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7519							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCTCTCTGATGACTTCACC	0.448													G	179584862	G	G	179584862	3	3	118	1	0	0	0	0	1	0	0	0	16732	333	12	4	81150	4	TTN	2	179584862	Missense_Mutation	SNP	A	TCGA-12-1597-01B-01D-1495-08	130100	179584862	63614511	14	8078											
ZDBF2	57683	broad.mit.edu	37	chr2	207173138	207173138	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcatgaaccccttcagtccGtaactaataaaattccaggg	6	12	2	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:207173138G>A	uc002vbp.2	+	5	4136	c.3886G>A	c.(3886-3888)GTA>ATA	p.V1296I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1296							nucleic acid binding|zinc ion binding			ovary(3)	3						CCTTCAGTCCGTAACTAATAA	0.383													A	207173138	A	A	207173138	3	1	118	1	0	0	0	0	1	0	0	0	17596	1145	40	1	3896	1	ZDBF2	2	207173138	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	27588276	207173138	36026235	15	8079											
SPEG	10290	broad.mit.edu	37	chr2	220346370	220346370	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcattcacaggagacctaccGcagaagagaccctagaacat	8	12	2	4			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:220346370G>A	uc010fwg.2	+	28	5533	c.5533G>A	c.(5533-5535)GCA>ACA	p.A1845T		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1845	Protein kinase 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GAGACCTACCGCAGAAGAGAC	0.443													A	220346370	A	A	220346370	3	1	118	1	0	0	0	0	1	0	0	0	15035	1087	38	1	5655	1	SPEG	2	220346370	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	13173232	220346370	22853003	16	8080											
DGKD	8527	broad.mit.edu	37	chr2	234360642	234360642	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatgtctggttccttacccGgtggctcagtcatcagtcgc	11	12	4	0	rs145038453	byFrequency	TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:234360642G>A	uc002vui.1	+	18	2212	c.2200G>A	c.(2200-2202)GGT>AGT	p.G734S	DGKD_uc002vuj.1_Missense_Mutation_p.G690S|DGKD_uc010fyh.1_Missense_Mutation_p.G601S|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	734					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	TTCCTTACCCGGTGGCTCAGT	0.493													A	234360642	A	A	234360642	3	1	118	1	0	0	0	0	1	0	0	0	4467	1116	39	2	2294	2	DGKD	2	234360642	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	14014272	234360642	8838731	17	8081											
GPR35	2859	broad.mit.edu	37	chr2	241569721	241569721	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtggaccgctatgtggccGtgcggcacccgctgcgtgcc	15	16	0	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:241569721G>A	uc002vzs.1	+	1	927	c.352G>A	c.(352-354)GTG>ATG	p.V118M	GPR35_uc010fzh.1_Missense_Mutation_p.V149M|GPR35_uc010fzi.1_Missense_Mutation_p.V149M	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	118	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		CTATGTGGCCGTGCGGCACCC	0.701													A	241569721	A	A	241569721	3	1	118	1	0	0	0	0	1	0	0	0	6690	1145	40	1	354	1	GPR35	2	241569721	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	7209079	241569721	1629652	18	8082											
DTYMK	1841	broad.mit.edu	37	chr2	242617899	242617899	+	Frame_Shift_Del	DEL	G	-	-													agtcgtgtctttcatgagctGgtggaaacaccggagcgccc							TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr2:242617899delG	uc002wbz.1	-	4	525	c.496delC	c.(496-498)CAGfs	p.Q166fs	DTYMK_uc010zpa.1_Frame_Shift_Del_p.Q142fs|DTYMK_uc010zpb.1_RNA|DTYMK_uc002wca.1_RNA|DTYMK_uc002wcb.1_5'Flank	NM_012145	NP_036277	P23919	KTHY_HUMAN	deoxythymidylate kinase (thymidylate kinase)	166					cell cycle|cell proliferation|nucleobase, nucleoside and nucleotide interconversion	cytosol	ATP binding|nucleoside phosphate kinase activity|thymidylate kinase activity				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.6e-33)|all cancers(36;3.57e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.23e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		TTCATGAGCTGGTGGAAACAC	0.582													-	242617899	-	-	242617899	7	5	118	1	0	1	0	1	0	0	0	0	4798	1357	47	0	150	0	DTYMK	2	242617899	Frame_Shift_Del	DEL	G	TCGA-12-1597-01B-01D-1495-08	1048178	242617899	581474	19	8083											
MST1R	4486	broad.mit.edu	37	chr3	49940449	49940449	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgtccagtgaggatgccacGtagaaataggaggcctggcc	15	10	0	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr3:49940449G>A	uc003cxy.3	-	1	858	c.594C>T	c.(592-594)TAC>TAT	p.Y198Y	MST1R_uc011bdd.1_Silent_p.Y198Y|MST1R_uc011bde.1_Silent_p.Y198Y|MST1R_uc011bdf.1_Silent_p.Y198Y|MST1R_uc011bdg.1_Silent_p.Y198Y	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	198	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		AGGATGCCACGTAGAAATAGG	0.632													A	49940449	A	A	49940449	2	1	118	1	0	0	0	0	0	0	0	1	9891	1140	40	1		1	MST1R	3	49940449	Silent	SNP	G	TCGA-12-1597-01B-01D-1495-08		49940449	148081981	20	8084											
FLNB	2317	broad.mit.edu	37	chr3	58145402	58145402	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaggagtgccacgtgtctgAgctggagccaggtgagcagg	19	8	1	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr3:58145402A>C	uc003djj.2	+	42	7175	c.7010A>C	c.(7009-7011)GAG>GCG	p.E2337A	FLNB_uc010hne.2_Missense_Mutation_p.E2368A|FLNB_uc003djk.2_Missense_Mutation_p.E2326A|FLNB_uc010hnf.2_Missense_Mutation_p.E2313A|FLNB_uc003djl.2_Missense_Mutation_p.E2157A|FLNB_uc003djm.2_Missense_Mutation_p.E2144A	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2337	Filamin 22.|Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CACGTGTCTGAGCTGGAGCCA	0.572													C	58145402	C	C	58145402	3	2	118	1	0	0	0	0	1	0	0	0	5934	304	11	5	7273	5	FLNB	3	58145402	Missense_Mutation	SNP	A	TCGA-12-1597-01B-01D-1495-08	8204953	58145402	139877028	21	8085											
OR5H1	26341	broad.mit.edu	37	chr3	97852262	97852262	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	taaggaaagccttttccaccTgtggagcccatctcttctct	7	13	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr3:97852262T>A	uc011bgt.1	+	1	721	c.721T>A	c.(721-723)TGT>AGT	p.C241S		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						CTTTTCCACCTGTGGAGCCCA	0.408													A	97852262	A	A	97852262	3	1	118	1	0	0	0	0	1	0	0	0	11159	1580	55	5	723	5	OR5H1	3	97852262	Missense_Mutation	SNP	T	TCGA-12-1597-01B-01D-1495-08	39706860	97852262	100170168	22	8086											
CPZ	8532	broad.mit.edu	37	chr4	8605776	8605776	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcttcagccaccactcctaCgcccagatggtgcgtgtgct	10	16	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr4:8605776C>T	uc003glm.2	+	4	696	c.570C>T	c.(568-570)TAC>TAT	p.Y190Y	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Silent_p.Y53Y|CPZ_uc003glo.2_Silent_p.Y179Y|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	190					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						ACCACTCCTACGCCCAGATGG	0.706													T	8605776	T	T	8605776	2	4	118	1	0	0	0	0	0	0	0	1	3839	547	19	1		1	CPZ	4	8605776	Silent	SNP	C	TCGA-12-1597-01B-01D-1495-08		8605776	182548500	23	8087											
WDR1	9948	broad.mit.edu	37	chr4	10100717	10100718	+	In_Frame_Ins	INS	-	TGCTCC	TGCTCC													ggtactcatacttcaacaggINStgctccttctgcgtggtatc							TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr4:10100717_10100718insTGCTCC	uc003gmf.2	-	4	558_559	c.275_276insGGAGCA	c.(274-276)CAC>CAGGAGCAC	p.91_92insQE	WDR1_uc003gmg.2_Intron	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	91_92	WD 1.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		ACTTCAACAGGTGCTCCTTCTG	0.589													TGCTCC	10100718	TGCTCC	TGCTCC	10100717	7	5	118	1	0	1	1	0	0	0	0	0	17269	1252	44	0	1592	0	WDR1	4	10100717	In_Frame_Ins	INS	-	TCGA-12-1597-01B-01D-1495-08	1494941	10100717	181053559	24	8088											
HCN1	348980	broad.mit.edu	37	chr5	45262443	45262443	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgtctgtggctgcggggaCggctgctgtggctgagtctg	20	8	2	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr5:45262443C>T	uc003jok.2	-	8	2278	c.2253G>A	c.(2251-2253)CCG>CCA	p.P751P		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	751	Gln-rich.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GCTGCGGGGACGgctgctgtg	0.428													T	45262443	T	T	45262443	2	4	118	1	0	0	0	0	0	0	0	1	6996	523	19	1		1	HCN1	5	45262443	Silent	SNP	C	TCGA-12-1597-01B-01D-1495-08		45262443	135652817	25	8089											
KCNN2	3781	broad.mit.edu	37	chr5	113740368	113740368	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctctatctgattgccagagtCatgcttttacatagcaaact	6	10	3	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr5:113740368C>T	uc003kqo.2	+	3	1273	c.816C>T	c.(814-816)GTC>GTT	p.V272V		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	272	Helical; Name=Segment S4; (Potential).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TTGCCAGAGTCATGCTTTTAC	0.393													T	113740368	T	T	113740368	2	4	118	1	0	0	0	0	0	0	0	1	8079	813	29	3		3	KCNN2	5	113740368	Silent	SNP	C	TCGA-12-1597-01B-01D-1495-08	68477925	113740368	67174892	26	8090											
MAT2B	27430	broad.mit.edu	37	chr5	162932707	162932707	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gcgggcatggtggggcgggaGaaagagctctctatacactt	16	8	1	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr5:162932707G>A	uc003lzk.2	+	1	123	c.15G>A	c.(13-15)GAG>GAA	p.E5E	MAT2B_uc003lzj.2_Intron|MAT2B_uc003lzl.1_Silent_p.E5E	NM_013283	NP_037415	Q9NZL9	MAT2B_HUMAN	methionine adenosyltransferase II, beta isoform	5					extracellular polysaccharide biosynthetic process|methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol|methionine adenosyltransferase complex|nucleus	dTDP-4-dehydrorhamnose reductase activity|methionine adenosyltransferase regulator activity|protein binding			upper_aerodigestive_tract(1)	1	Renal(175;0.000281)	Medulloblastoma(196;0.0208)|all_neural(177;0.0765)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.027)|OV - Ovarian serous cystadenocarcinoma(192;0.0406)|Epithelial(171;0.0797)	L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TGGGGCGGGAGAAAGAGCTCT	0.706											OREG0017003	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	162932707	A	A	162932707	2	1	118	1	0	0	0	0	0	0	0	1	9331	933	33	3		3	MAT2B	5	162932707	Silent	SNP	G	TCGA-12-1597-01B-01D-1495-08	49192339	162932707	17982553	27	8091											
SLC17A1	6568	broad.mit.edu	37	chr6	25819769	25819769	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catagaagtaagtcggcctcGttccaggggaggagcccatt	13	10	0	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr6:25819769G>A	uc003nfh.3	-	5	615	c.499C>T	c.(499-501)CGA>TGA	p.R167*	SLC17A1_uc011djy.1_RNA|SLC17A1_uc010jqb.1_Nonsense_Mutation_p.R165*|SLC17A1_uc010jqc.1_Nonsense_Mutation_p.R165*	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	167					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						AGTCGGCCTCGTTCCAGGGGA	0.398													A	25819769	A	A	25819769	4	1	118	1	0	0	0	0	0	1	0	0	14416	1153	40	1	936	1	SLC17A1	6	25819769	Nonsense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08		25819769	145295298	28	8092											
PGBD1	84547	broad.mit.edu	37	chr6	28269724	28269724	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatggcattatcagtctgtGctccaatgctgtgggcatag	13	8	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr6:28269724G>A	uc003nky.2	+	7	2463	c.2093G>A	c.(2092-2094)TGC>TAC	p.C698Y	PGBD1_uc003nkz.2_Missense_Mutation_p.C698Y	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	698					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						ATCAGTCTGTGCTCCAATGCT	0.388													A	28269724	A	A	28269724	3	1	118	1	0	0	0	0	1	0	0	0	11780	1319	46	3	2115	3	PGBD1	6	28269724	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	2449955	28269724	142845343	29	8093											
TREML2	79865	broad.mit.edu	37	chr6	41166020	41166020	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccctttcacccagactcggGcaaagccaggctcacacttc	8	17	2	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr6:41166020G>A	uc010jxm.1	-	2	382	c.203C>T	c.(202-204)GCC>GTC	p.A68V		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	68	Ig-like V-type.|Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCAGACTCGGGCAAAGCCAGG	0.572													A	41166020	A	A	41166020	3	1	118	1	0	0	0	0	1	0	0	0	16470	1203	42	3	778	3	TREML2	6	41166020	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	12896296	41166020	129949047	30	8094											
AKAP9	10142	broad.mit.edu	37	chr7	91674419	91674419	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacaattggtcgccatgtcCttgggattctagatagatct	9	8	2	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr7:91674419C>T	uc003ulg.2	+	21	5485	c.5260C>T	c.(5260-5262)CTT>TTT	p.L1754F	AKAP9_uc003ulf.2_Missense_Mutation_p.L1754F|AKAP9_uc003uli.2_Missense_Mutation_p.L1379F	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1766					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCGCCATGTCCTTGGGATTCT	0.423			T	BRAF	papillary thyroid								T	91674419	T	T	91674419	3	4	118	1	0	0	0	0	1	0	0	0	459	681	24	3	5342	3	AKAP9	7	91674419	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		91674419	67464244	31	8095											
PPP1R3A	5506	broad.mit.edu	37	chr7	113519263	113519263	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaacttggaaaagataatcAttcctcaaaacatttccagt	4	9	3	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr7:113519263A>G	uc010ljy.1	-	4	1915	c.1884T>C	c.(1882-1884)AAT>AAC	p.N628N		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	628					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						AAAGATAATCATTCCTCAAAA	0.388													G	113519263	G	G	113519263	2	3	118	1	0	0	0	0	0	0	0	1	12371	214	8	4		4	PPP1R3A	7	113519263	Silent	SNP	A	TCGA-12-1597-01B-01D-1495-08	21844844	113519263	45619400	32	8096											
TRPV6	55503	broad.mit.edu	37	chr7	142573411	142573411	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaccagctccttcaccggcGtctggtccaggatctggcga	11	15	4	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr7:142573411G>A	uc003wbx.1	-	8	1148	c.932C>T	c.(931-933)ACG>ATG	p.T311M	TRPV6_uc003wbw.1_Missense_Mutation_p.T97M|TRPV6_uc010lou.1_Missense_Mutation_p.T182M	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	311	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CTTCACCGGCGTCTGGTCCAG	0.592													A	142573411	A	A	142573411	3	1	118	1	0	0	0	0	1	0	0	0	16597	1145	40	1	1277	1	TRPV6	7	142573411	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	29054148	142573411	16565252	33	8097											
OR2F1	26211	broad.mit.edu	37	chr7	143657660	143657660	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcctccaatgaggtcaccatCatggtgtctagcattgttct	8	11	4	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr7:143657660C>T	uc003wds.1	+	1	641	c.597C>T	c.(595-597)ATC>ATT	p.I199I		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					AGGTCACCATCATGGTGTCTA	0.478													T	143657660	T	T	143657660	2	4	118	1	0	0	0	0	0	0	0	1	10996	816	29	3		3	OR2F1	7	143657660	Silent	SNP	C	TCGA-12-1597-01B-01D-1495-08	1084249	143657660	15481003	34	8098											
CNTNAP2	26047	broad.mit.edu	37	chr7	146741054	146741054	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggcacgaattacagcatcCgattattgcccgctatgtgc	9	13	0	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr7:146741054C>T	uc003weu.1	+	4	974	c.458C>T	c.(457-459)CCG>CTG	p.P153L		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	153	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTACAGCATCCGATTATTGCC	0.423										HNSCC(39;0.1)			T	146741054	T	T	146741054	3	4	118	1	0	0	0	0	1	0	0	0	3647	652	23	2	472	2	CNTNAP2	7	146741054	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	3083394	146741054	12397609	35	8099											
DLC1	10395	broad.mit.edu	37	chr8	12946050	12946050	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatactgttttggacatacTggtaaatttcagtttggctg	9	7	1	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr8:12946050T>C	uc003wwm.2	-	16	4682	c.4238A>G	c.(4237-4239)CAG>CGG	p.Q1413R	DLC1_uc003wwk.1_Missense_Mutation_p.Q976R|DLC1_uc003wwl.1_Missense_Mutation_p.Q1010R|DLC1_uc011kxx.1_Missense_Mutation_p.Q902R	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1413	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TTGGACATACTGGTAAATTTC	0.423													C	12946050	C	C	12946050	3	2	118	1	0	0	0	0	1	0	0	0	4550	1580	55	4	360	4	DLC1	8	12946050	Missense_Mutation	SNP	T	TCGA-12-1597-01B-01D-1495-08		12946050	133417972	36	8100											
ADAM2	2515	broad.mit.edu	37	chr8	39607192	39607192	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtactgctacttacacctctAtcattgcatttgtcagtagt	6	10	3	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr8:39607192A>G	uc003xnj.2	-	17	1944	c.1869T>C	c.(1867-1869)GAT>GAC	p.D623D	ADAM2_uc003xnk.2_Silent_p.D604D|ADAM2_uc011lck.1_Silent_p.D560D|ADAM2_uc003xnl.2_Silent_p.D467D	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	623	Extracellular (Potential).|EGF-like.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TTACACCTCTATCATTGCATT	0.294													G	39607192	G	G	39607192	2	3	118	1	0	0	0	0	0	0	0	1	241	446	16	4		4	ADAM2	8	39607192	Silent	SNP	A	TCGA-12-1597-01B-01D-1495-08	26661142	39607192	106756830	37	8101											
TTPA	7274	broad.mit.edu	37	chr8	63985639	63985639	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctctccacttataatagttTtttagtaactgaaaaataaa	4	6	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr8:63985639T>C	uc003xux.1	-	2	245	c.213A>G	c.(211-213)AAA>AAG	p.K71K		NM_000370	NP_000361	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	71					lipid metabolic process		transporter activity|vitamin E binding				0	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	TATAATAGTTTTTTAGTAACT	0.338													C	63985639	C	C	63985639	2	2	118	1	0	0	0	0	0	0	0	1	16733	1838	64	4		4	TTPA	8	63985639	Silent	SNP	T	TCGA-12-1597-01B-01D-1495-08	24378447	63985639	82378383	38	8102											
RIMS2	9699	broad.mit.edu	37	chr8	105263256	105263256	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttttctttcccaagcaccGtatgtaaaagtgtatctatt	6	8	2	0	rs143698299	by1000genomes	TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr8:105263256G>A	uc003yls.2	+	27	3991	c.3750G>A	c.(3748-3750)CCG>CCA	p.P1250P	RIMS2_uc003ylp.2_Silent_p.P1232P|RIMS2_uc003ylw.2_Silent_p.P1239P|RIMS2_uc003ylq.2_Silent_p.P1046P|RIMS2_uc003ylr.2_Silent_p.P1071P	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1294	C2 2.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCCAAGCACCGTATGTAAAAG	0.408										HNSCC(12;0.0054)			A	105263256	A	A	105263256	2	1	118	1	0	0	0	0	0	0	0	1	13368	1132	40	1		1	RIMS2	8	105263256	Silent	SNP	G	TCGA-12-1597-01B-01D-1495-08	41277617	105263256	41100766	39	8103											
CPSF1	29894	broad.mit.edu	37	chr8	145624415	145624415	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caatctccaggtccggctcgGggctgttctgaaactgcaca	11	13	2	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr8:145624415G>A	uc003zcj.2	-	16	1556	c.1481C>T	c.(1480-1482)CCC>CTC	p.P494L		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	494					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GTCCGGCTCGGGGCTGTTCTG	0.488													A	145624415	A	A	145624415	3	1	118	1	0	0	0	0	1	0	0	0	3824	1232	43	3	2942	3	CPSF1	8	145624415	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	40361159	145624415	739607	40	8104											
PGM5	5239	broad.mit.edu	37	chr9	70999452	70999452	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctagaaaacaaattcaaacCattcagaggtaacagagatt	6	8	2	3			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr9:70999452C>A	uc004agr.2	+	3	792	c.563C>A	c.(562-564)CCA>CAA	p.P188Q		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	188					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						AAATTCAAACCATTCAGAGGT	0.378													A	70999452	A	A	70999452	3	1	118	1	0	0	0	0	1	0	0	0	11801	594	21	5	573	5	PGM5	9	70999452	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		70999452	70213979	41	8105											
WNK2	65268	broad.mit.edu	37	chr9	96079849	96079849	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgccacgtctgcccccagcGcccggccctctgtccaccac	8	22	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr9:96079849G>A	uc004ati.1	+	29	6675	c.6675G>A	c.(6673-6675)GCG>GCA	p.A2225A	WNK2_uc011lud.1_Silent_p.A2188A|WNK2_uc004atj.2_Silent_p.A2188A|WNK2_uc004atk.2_Silent_p.A1713A	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	2225					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						TGCCCCCAGCGCCCGGCCCTC	0.647													A	96079849	A	A	96079849	2	1	118	1	0	0	0	0	0	0	0	1	17375	1074	38	1		1	WNK2	9	96079849	Silent	SNP	G	TCGA-12-1597-01B-01D-1495-08	25080397	96079849	45133582	42	8106											
C10orf72	196740	broad.mit.edu	37	chr10	50285318	50285318	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgatgaccagcatgaagaGcagaatgctgaggatcccca	12	10	0	5			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr10:50285318G>A	uc001jhf.2	-	4	609	c.580C>T	c.(580-582)CTC>TTC	p.L194F		NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	194	Helical; (Potential).					integral to membrane|plasma membrane					0						AGCATGAAGAGCAGAATGCTG	0.532													A	50285318	A	A	50285318	3	1	118	1	0	0	0	0	1	0	0	0	1615	971	34	3	402	3	C10orf72	10	50285318	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08		50285318	85249429	43	8107											
PTEN	5728	broad.mit.edu	37	chr10	89717704	89717704	+	Frame_Shift_Del	DEL	C	-	-													aagttcatgtactttgagttCcctcagccgttacctgtgtg							TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr10:89717704delC	uc001kfb.2	+	8	1760	c.729delC	c.(727-729)TTCfs	p.F243fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	243	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.F243fs*9(1)|p.R234fs*9(1)|p.F243S(1)|p.F243fs*13(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ACTTTGAGTTCCCTCAGCCGT	0.423		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89717704	-	-	89717704	7	5	118	1	0	1	0	1	0	0	0	0	12738	854	30	0	755	0	PTEN	10	89717704	Frame_Shift_Del	DEL	C	TCGA-12-1597-01B-01D-1495-08	39432386	89717704	45817043	44	8108											
MRGPRE	116534	broad.mit.edu	37	chr11	3249597	3249597	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagagggcccaggtgagggCgcacacacaggtggtcaggt	18	10	1	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr11:3249597C>T	uc001lxq.3	-	2	740	c.430G>A	c.(430-432)GCC>ACC	p.A144T		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	144	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGGTGAGGGCGCACACACAG	0.711													T	3249597	T	T	3249597	3	4	118	1	0	0	0	0	1	0	0	0	9764	768	27	1	509	1	MRGPRE	11	3249597	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		3249597	131756919	45	8109											
OR8K3	219473	broad.mit.edu	37	chr11	56086025	56086025	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaactgtgggacccaaaatGttagtaaattttgttgtgga	10	5	0	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr11:56086025G>A	uc010rjf.1	+	1	243	c.243G>A	c.(241-243)ATG>ATA	p.M81I		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					GACCCAAAATGTTAGTAAATT	0.353													A	56086025	A	A	56086025	3	1	118	1	0	0	0	0	1	0	0	0	11244	1377	48	3	245	3	OR8K3	11	56086025	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	52836428	56086025	78920491	46	8110											
MAP4K2	5871	broad.mit.edu	37	chr11	64557670	64557670	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gctcactcacccacagtctcGatggggaaatcaaaggtcag	10	12	5	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr11:64557670G>A	uc001obh.2	-	29	2330	c.2238C>T	c.(2236-2238)ATC>ATT	p.I746I	MAP4K2_uc001obg.2_RNA|MAP4K2_uc001obi.2_Silent_p.I738I	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	746	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						CCACAGTCTCGATGGGGAAAT	0.617													A	64557670	A	A	64557670	2	1	118	1	0	0	0	0	0	0	0	1	9260	1048	37	2		2	MAP4K2	11	64557670	Silent	SNP	G	TCGA-12-1597-01B-01D-1495-08	8471645	64557670	70448846	47	8111											
FAM55D	54827	broad.mit.edu	37	chr11	114453106	114453106	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cacagggcatgtgttgaggcCtcacacagtagaagccttct	11	11	2	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr11:114453106C>A	uc001ppc.2	-	3	915	c.734G>T	c.(733-735)AGG>ATG	p.R245M	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	245						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		GTGTTGAGGCCTCACACAGTA	0.438													A	114453106	A	A	114453106	3	1	118	1	0	0	0	0	1	0	0	0	5587	681	24	5	916	5	FAM55D	11	114453106	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	49895436	114453106	20553410	48	8112											
KRT4	3851	broad.mit.edu	37	chr12	53207484	53207484	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caatctccacgtggagggggGtgagcaagctctggttgatg	16	8	2	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr12:53207484G>T	uc001saz.2	-	1	852	c.581C>A	c.(580-582)ACC>AAC	p.T194N		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	120						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						GTGGAGGGGGGTGAGCAAGCT	0.587													T	53207484	T	T	53207484	3	4	118	1	0	0	0	0	1	0	0	0	8477	1261	44	5	1239	5	KRT4	12	53207484	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08		53207484	80644411	49	8113											
OR6C1	390321	broad.mit.edu	37	chr12	55714593	55714593	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctccatattagaaatttcGttcacaaccgtcagtatacc	4	11	3	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr12:55714593G>A	uc010spi.1	+	1	210	c.210G>A	c.(208-210)TCG>TCA	p.S70S		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						TAGAAATTTCGTTCACAACCG	0.383													A	55714593	A	A	55714593	2	1	118	1	0	0	0	0	0	0	0	1	11190	1132	40	1		1	OR6C1	12	55714593	Silent	SNP	G	TCGA-12-1597-01B-01D-1495-08	2507109	55714593	78137302	50	8114											
PAH	5053	broad.mit.edu	37	chr12	103246614	103246614	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gttcgggggtatacatgggcTtggatccatgtctgatgtac	14	7	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr12:103246614T>A	uc001tjq.1	-	8	1293	c.821A>T	c.(820-822)AAG>ATG	p.K274M		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	274			K -> E.		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	ATACATGGGCTTGGATCCATG	0.562													A	103246614	A	A	103246614	3	1	118	1	0	0	0	0	1	0	0	0	11394	1609	56	5	565	5	PAH	12	103246614	Missense_Mutation	SNP	T	TCGA-12-1597-01B-01D-1495-08	47532021	103246614	30605281	51	8115											
EXOSC8	11340	broad.mit.edu	37	chr13	37580266	37580266	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atcaagttcacagataattcAgaaagaggacttatgcattt	7	6	3	3			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr13:37580266A>C	uc001uwa.2	+	7	624	c.359A>C	c.(358-360)CAG>CCG	p.Q120P	EXOSC8_uc001uvz.2_RNA|EXOSC8_uc001uwb.2_Missense_Mutation_p.Q120P|EXOSC8_uc001uwc.2_RNA	NM_181503	NP_852480	Q96B26	EXOS8_HUMAN	exosome component 8	120					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	AU-rich element binding|identical protein binding			pancreas(1)	1		Lung NSC(96;6.57e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.67e-07)|Epithelial(112;1.31e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00699)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0411)		CAGATAATTCAGAAAGAGGAC	0.318													C	37580266	C	C	37580266	3	2	118	1	0	0	0	0	1	0	0	0	5320	188	7	5	385	5	EXOSC8	13	37580266	Missense_Mutation	SNP	A	TCGA-12-1597-01B-01D-1495-08		37580266	77589612	52	8116											
FANCM	57697	broad.mit.edu	37	chr14	45605251	45605251	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cctaatgagcggacggcaaaGaacgctttttcagacgtggg	13	9	1	3			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr14:45605251G>A	uc001wwd.3	+	1	116	c.17G>A	c.(16-18)AGA>AAA	p.R6K	FANCM_uc001wwc.2_Missense_Mutation_p.R6K|FANCM_uc010anf.2_Missense_Mutation_p.R6K|FKBP3_uc010tqf.1_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	6					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						GGACGGCAAAGAACGCTTTTT	0.582								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				A	45605251	A	A	45605251	3	1	118	1	0	0	0	0	1	0	0	0	5671	942	33	3	19	3	FANCM	14	45605251	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08		45605251	61744289	53	8117											
NAA30	122830	broad.mit.edu	37	chr14	57858239	57858239	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagcaggtgcggctgctgtcTtcgtccctgaccgccgactg	14	14	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr14:57858239T>G	uc001xcx.3	+	2	718	c.564T>G	c.(562-564)TCT>TCG	p.S188S	NAA30_uc010trk.1_Intron|NAA30_uc010aow.2_Intron	NM_001011713	NP_001011713	Q147X3	NAA30_HUMAN	N-acetyltransferase 12	188						cytoplasm	peptide alpha-N-acetyltransferase activity			skin(1)	1						GGCTGCTGTCTTCGTCCCTGA	0.657													G	57858239	G	G	57858239	2	3	118	1	0	0	0	0	0	0	0	1	10122	1596	56	5		5	NAA30	14	57858239	Silent	SNP	T	TCGA-12-1597-01B-01D-1495-08	12252988	57858239	49491301	54	8118											
TSHR	7253	broad.mit.edu	37	chr14	81610003	81610003	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcgcctggaccggaagatccGcctcaggcacgcatgtgcca	13	15	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr14:81610003G>T	uc001xvd.1	+	10	1757	c.1601G>T	c.(1600-1602)CGC>CTC	p.R534L		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	534	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CGGAAGATCCGCCTCAGGCAC	0.562			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						T	81610003	T	T	81610003	3	4	118	1	0	0	0	0	1	0	0	0	16619	1087	38	5	1776	5	TSHR	14	81610003	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	23751764	81610003	25739537	55	8119											
IFI27	3429	broad.mit.edu	37	chr14	94582172	94582172	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgccatgggcttcactgcggCgggaatcgcctcgtcctcca	12	15	1	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr14:94582172C>G	uc010tws.1	+	4	355	c.234C>G	c.(232-234)GGC>GGG	p.G78G	IFI27_uc001ycn.1_RNA|IFI27_uc001yco.2_Missense_Mutation_p.A59G	NM_005532	NP_005523	P40305	IFI27_HUMAN	interferon, alpha-inducible protein 27 isoform	Error:Variant_position_missing_in_P40305_after_alignment					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion					0				Epithelial(152;0.112)|all cancers(159;0.187)|COAD - Colon adenocarcinoma(157;0.206)		TTCACTGCGGCGGGAATCGCC	0.642													G	94582172	G	G	94582172	2	3	118	1	0	0	0	0	0	0	0	1	7512	768	27	5		5	IFI27	14	94582172	Silent	SNP	C	TCGA-12-1597-01B-01D-1495-08	12972169	94582172	12767368	56	8120											
MGA	23269	broad.mit.edu	37	chr15	42032290	42032290	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctgcatccaggaaaccaCgtaccctgttgccttcaaca	8	14	1	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr15:42032290C>T	uc010ucy.1	+	14	4655	c.4474C>T	c.(4474-4476)CGT>TGT	p.R1492C	MGA_uc010ucz.1_Missense_Mutation_p.R1492C|MGA_uc010uda.1_Missense_Mutation_p.R108C	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1492						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CAGGAAACCACGTACCCTGTT	0.532													T	42032290	T	T	42032290	3	4	118	1	0	0	0	0	1	0	0	0	9540	536	19	1	4524	1	MGA	15	42032290	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		42032290	60499102	57	8121											
LRRK1	79705	broad.mit.edu	37	chr15	101592102	101592102	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catctcctgccccagacaccCggacctccccgtgccgctgc	8	22	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr15:101592102C>T	uc002bwr.2	+	24	3945	c.3626C>T	c.(3625-3627)CCG>CTG	p.P1209L	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_5'Flank	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1209					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCCAGACACCCGGACCTCCCC	0.617													T	101592102	T	T	101592102	3	4	118	1	0	0	0	0	1	0	0	0	9032	652	23	2	3716	2	LRRK1	15	101592102	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	59559812	101592102	939290	58	8122											
SALL1	6299	broad.mit.edu	37	chr16	51171034	51171034	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgagctgctttaactcgtgaCgatctccttgctgtcctcca	8	14	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr16:51171034C>G	uc010vgs.1	-	3	3995	c.3964G>C	c.(3964-3966)GTC>CTC	p.V1322L	SALL1_uc010vgr.1_Missense_Mutation_p.V1225L|SALL1_uc010cbv.2_Missense_Mutation_p.V174L	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1322					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TAACTCGTGACGATCTCCTTG	0.592													G	51171034	G	G	51171034	3	3	118	1	0	0	0	0	1	0	0	0	13810	536	19	5	14	5	SALL1	16	51171034	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		51171034	39183719	59	8123											
GNAO1	2775	broad.mit.edu	37	chr16	56374784	56374784	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctgaagctttttgacagcatCtgcaacaacaaatggttcac	7	10	2	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr16:56374784C>G	uc002eit.3	+	7	1659	c.762C>G	c.(760-762)ATC>ATG	p.I254M	GNAO1_uc002eiu.3_Intron	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	254					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				TTGACAGCATCTGCAACAACA	0.527													G	56374784	G	G	56374784	3	3	118	1	0	0	0	0	1	0	0	0	6508	903	32	5	788	5	GNAO1	16	56374784	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	5203750	56374784	33979969	60	8124											
PMFBP1	83449	broad.mit.edu	37	chr16	72158703	72158703	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggttctcttttaaggcgGccatctcctcctggaactcc	10	13	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr16:72158703G>A	uc002fcc.3	-	17	2739	c.2567C>T	c.(2566-2568)GCC>GTC	p.A856V	PMFBP1_uc002fcd.2_Missense_Mutation_p.A851V|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.A706V|PMFBP1_uc010cgo.1_Missense_Mutation_p.A147V	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	856	Potential.									ovary(2)	2		Ovarian(137;0.179)				TTTTAAGGCGGCCATCTCCTC	0.572											OREG0023927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	72158703	A	A	72158703	3	1	118	1	0	0	0	0	1	0	0	0	12134	1203	42	3	551	3	PMFBP1	16	72158703	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	15783919	72158703	18196050	61	8125											
GAN	8139	broad.mit.edu	37	chr16	81390535	81390535	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagccagccgcagcaaggggAggcgatgctggccaacttca	14	13	1	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr16:81390535A>G	uc002fgo.2	+	4	927	c.779A>G	c.(778-780)GAG>GGG	p.E260G		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	260					cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				CAGCAAGGGGAGGCGATGCTG	0.493													G	81390535	G	G	81390535	3	3	118	1	0	0	0	0	1	0	0	0	6232	304	11	4	793	4	GAN	16	81390535	Missense_Mutation	SNP	A	TCGA-12-1597-01B-01D-1495-08	9231832	81390535	8964218	62	8126											
FBXO31	79791	broad.mit.edu	37	chr16	87367838	87367838	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gaggtcgggcagctggatccGatgcctcaggtcgatctcca	14	12	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr16:87367838G>C	uc002fjw.2	-	8	1095	c.1051C>G	c.(1051-1053)CGG>GGG	p.R351G	FBXO31_uc010vot.1_Missense_Mutation_p.R179G|FBXO31_uc002fjv.2_Missense_Mutation_p.R243G	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	351					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		AGCTGGATCCGATGCCTCAGG	0.657													C	87367838	C	C	87367838	3	2	118	1	0	0	0	0	1	0	0	0	5741	1057	37	5	576	5	FBXO31	16	87367838	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	5977303	87367838	2986915	63	8127											
BCL6B	255877	broad.mit.edu	37	chr17	6929925	6929925	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agggcaaccttgccagtcatCgtacagtgcacacaggtagg	12	11	1	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr17:6929925C>T	uc002geg.2	+	6	1096	c.1039C>T	c.(1039-1041)CGT>TGT	p.R347C	BCL6B_uc010clt.1_Missense_Mutation_p.R348C	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	347	C2H2-type 1.					nucleus	zinc ion binding			skin(1)	1						TGCCAGTCATCGTACAGTGCA	0.582													T	6929925	T	T	6929925	3	4	118	1	0	0	0	0	1	0	0	0	1377	884	31	2	1057	2	BCL6B	17	6929925	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		6929925	74265285	64	8128											
MAP2K3	5606	broad.mit.edu	37	chr17	21208414	21208414	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agggctacaatgtcaagtccGacgtctggagcctgggcatc	13	11	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr17:21208414G>A	uc002gys.2	+	9	1013	c.748G>A	c.(748-750)GAC>AAC	p.D250N	MAP2K3_uc002gyt.2_Missense_Mutation_p.D221N|MAP2K3_uc002gyu.2_Missense_Mutation_p.D221N	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	250	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		TGTCAAGTCCGACGTCTGGAG	0.577													A	21208414	A	A	21208414	3	1	118	1	0	0	0	0	1	0	0	0	9238	1058	37	2	782	2	MAP2K3	17	21208414	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	14278489	21208414	59986796	65	8129											
LGALS9	3965	broad.mit.edu	37	chr17	25974373	25974373	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatgagaatgctgtggtccGcaacacccagatcgacaact	10	11	0	3	rs149003631		TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr17:25974373G>A	uc002gzp.2	+	10	954	c.836G>A	c.(835-837)CGC>CAC	p.R279H	LGALS9_uc002gzq.2_Missense_Mutation_p.R247H|LGALS9_uc002gzr.2_Missense_Mutation_p.R190H|LGALS9_uc010waa.1_Intron|LGALS9_uc002gzs.2_Intron	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	279	Galectin 2.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		GCTGTGGTCCGCAACACCCAG	0.587													A	25974373	A	A	25974373	3	1	118	1	0	0	0	0	1	0	0	0	8748	1087	38	1	874	1	LGALS9	17	25974373	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	4765959	25974373	55220837	66	8130											
SSH2	85464	broad.mit.edu	37	chr17	27977712	27977712	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtaagtgtcattccagtacgCcaggagatccgttgcctctt	10	11	2	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr17:27977712C>A	uc002heo.1	-	12	1105	c.1105G>T	c.(1105-1107)GCG>TCG	p.A369S	SSH2_uc010wbh.1_Missense_Mutation_p.A396S|SSH2_uc002hep.1_Missense_Mutation_p.A369S	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	369	Tyrosine-protein phosphatase.				actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TTCCAGTACGCCAGGAGATCC	0.428													A	27977712	A	A	27977712	3	1	118	1	0	0	0	0	1	0	0	0	15184	739	26	5	3182	5	SSH2	17	27977712	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	2003339	27977712	53217498	67	8131											
BPTF	2186	broad.mit.edu	37	chr17	65889772	65889775	+	Frame_Shift_Del	DEL	GACT	-	-													tcttaccatatctactctgaGactgactatcacccaattag							TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr17:65889772_65889775delGACT	uc002jgf.2	+	6	2403_2406	c.2342_2345delGACT	c.(2341-2346)AGACTGfs	p.R781fs	BPTF_uc002jge.2_Frame_Shift_Del_p.R907fs|BPTF_uc010wqm.1_Frame_Shift_Del_p.R844fs	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	907_908	Interaction with MAZ.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TCTACTCTGAGACTGACTATCACC	0.412													-	65889775	-	-	65889772	7	5	118	1	0	1	0	1	0	0	0	0	1495	942	33	0	2750	0	BPTF	17	65889772	Frame_Shift_Del	DEL	GACT	TCGA-12-1597-01B-01D-1495-08	37912060	65889772	15305438	68	8132											
RNF157	114804	broad.mit.edu	37	chr17	74157723	74157723	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcggatctgaagcagtgcccGgaaggctgtgaaggagaaaa	15	7	1	3			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr17:74157723G>A	uc002jqz.2	-	11	1027	c.958C>T	c.(958-960)CGG>TGG	p.R320W	RNF157_uc002jra.2_Missense_Mutation_p.R320W	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	320							zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			AGCAGTGCCCGGAAGGCTGTG	0.507													A	74157723	A	A	74157723	3	1	118	1	0	0	0	0	1	0	0	0	13454	1115	39	2	1117	2	RNF157	17	74157723	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	8267951	74157723	7037487	69	8133											
SMAD7	4092	broad.mit.edu	37	chr18	46447857	46447857	+	Frame_Shift_Del	DEL	G	-	-													gcacggtaaagcccgtccacGgctgctgcataaactcgtgg							TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr18:46447857delG	uc002ldg.2	-	4	1453	c.1166delC	c.(1165-1167)CCGfs	p.P389fs	SMAD7_uc002ldf.2_Frame_Shift_Del_p.P201fs|SMAD7_uc010xde.1_Frame_Shift_Del_p.P174fs	NM_005904	NP_005895	O15105	SMAD7_HUMAN	SMAD family member 7	389	MH2.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding				0	Colorectal(1;0.0518)					GCCCGTCCACGGCTGCTGCAT	0.582													-	46447857	-	-	46447857	7	5	118	1	0	1	0	1	0	0	0	0	14763	1116	39	0	118	0	SMAD7	18	46447857	Frame_Shift_Del	DEL	G	TCGA-12-1597-01B-01D-1495-08		46447857	31629391	70	8134											
LMAN1	3998	broad.mit.edu	37	chr18	57022568	57022568	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tccatcattgtcaaaagaatCaaaaaatattccaacaccat	2	10	3	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr18:57022568C>A	uc002lhz.2	-	3	486	c.454G>T	c.(454-456)GAT>TAT	p.D152Y	LMAN1_uc010xek.1_Missense_Mutation_p.D152Y	NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor	152	Lumenal (Potential).|L-type lectin-like.	Calcium.			blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	TCAAAAGAATCAAAAAATATT	0.353													A	57022568	A	A	57022568	3	1	118	1	0	0	0	0	1	0	0	0	8836	826	29	5	1122	5	LMAN1	18	57022568	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	10574711	57022568	21054680	71	8135											
LSR	51599	broad.mit.edu	37	chr19	35741541	35741541	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggagattactaccagggcCggaggattaccatcaccgga	13	10	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr19:35741541C>T	uc002nyl.2	+	2	800	c.577C>T	c.(577-579)CGG>TGG	p.R193W	LSR_uc002nym.2_Missense_Mutation_p.R193W|LSR_uc002nyn.2_Missense_Mutation_p.R193W|LSR_uc002nyo.2_Missense_Mutation_p.R193W|LSR_uc010xsr.1_Missense_Mutation_p.R193W|LSR_uc002nyp.2_Missense_Mutation_p.R156W	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	193	Extracellular (Potential).|Ig-like V-type.				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CTACCAGGGCCGGAGGATTAC	0.642													T	35741541	T	T	35741541	3	4	118	1	0	0	0	0	1	0	0	0	9064	643	23	2	583	2	LSR	19	35741541	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		35741541	23387442	72	8136											
ATP4A	495	broad.mit.edu	37	chr19	36046636	36046636	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agcgatgtcctccactgtctCgctgccttccgagatgatgc	10	14	1	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr19:36046636C>T	uc002oal.1	-	13	1977	c.1948G>A	c.(1948-1950)GAG>AAG	p.E650K	ATP4A_uc010eee.1_5'UTR	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	650	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TCCACTGTCTCGCTGCCTTCC	0.622													T	36046636	T	T	36046636	3	4	118	1	0	0	0	0	1	0	0	0	1145	893	31	2	1199	2	ATP4A	19	36046636	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	305095	36046636	23082347	73	8137											
PTGIS	5740	broad.mit.edu	37	chr20	48140704	48140704	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccatttgctccggtgggccCgcctggccagcctggctggg	16	15	0	0	rs45571835		TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr20:48140704C>T	uc002xut.2	-	6	800	c.746G>A	c.(745-747)CGG>CAG	p.R249Q	PTGIS_uc010zyi.1_Missense_Mutation_p.R110Q	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	249					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	CCGGTGGGCCCGCCTGGCCAG	0.627													T	48140704	T	T	48140704	3	4	118	1	0	0	0	0	1	0	0	0	12752	652	23	2	776	2	PTGIS	20	48140704	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		48140704	14884816	74	8138											
ATP9A	10079	broad.mit.edu	37	chr20	50225158	50225158	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggaaacatggtgtaaattgTggagtacctgggagagaaaa	14	3	0	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr20:50225158T>C	uc002xwg.1	-	25	2644	c.2644A>G	c.(2644-2646)ACA>GCA	p.T882A	ATP9A_uc010gih.1_Missense_Mutation_p.T746A|ATP9A_uc002xwf.1_Missense_Mutation_p.T54A	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	882	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						GTGTAAATTGTGGAGTACCTG	0.488													C	50225158	C	C	50225158	3	2	118	1	0	0	0	0	1	0	0	0	1198	1696	59	4	515	4	ATP9A	20	50225158	Missense_Mutation	SNP	T	TCGA-12-1597-01B-01D-1495-08	2084454	50225158	12800362	75	8139											
C20orf20	55257	broad.mit.edu	37	chr20	61430922	61430922	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agacaagcggaagcgcagccGggtcaccgacaaagtcctga	13	12	1	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr20:61430922G>A	uc002ydi.2	+	5	613	c.542G>A	c.(541-543)CGG>CAG	p.R181Q		NM_018270	NP_060740	Q9NV56	MRGBP_HUMAN	MRG-binding protein	181					chromatin modification|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	H4/H2A histone acetyltransferase complex					0	Breast(26;3.65e-08)					AAGCGCAGCCGGGTCACCGAC	0.582													A	61430922	A	A	61430922	3	1	118	1	0	0	0	0	1	0	0	0	2103	1116	39	2	560	2	C20orf20	20	61430922	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	11205764	61430922	1594598	76	8140											
KRTAP10-8	386681	broad.mit.edu	37	chr21	46032293	46032293	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccaatcaggctgcaccgaCtcctgcacaccttcatgctg	8	16	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr21:46032293C>T	uc002zfo.1	+	1	298	c.276C>T	c.(274-276)GAC>GAT	p.D92D	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198695	NP_941968	P60410	KR108_HUMAN	keratin associated protein 10-8	92	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|breast(1)	2						GCTGCACCGACTCCTGCACAC	0.662													T	46032293	T	T	46032293	2	4	118	1	0	0	0	0	0	0	0	1	8515	564	20	3		3	KRTAP10-8	21	46032293	Silent	SNP	C	TCGA-12-1597-01B-01D-1495-08		46032293	2097602	77	8141											
IL17RA	23765	broad.mit.edu	37	chr22	17589233	17589233	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgacctgatccccccaccgcTgaagcccaggaaggtctgga	11	15	1	3			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr22:17589233T>C	uc002zly.2	+	13	1257	c.1124T>C	c.(1123-1125)CTG>CCG	p.L375P	IL17RA_uc010gqt.2_Missense_Mutation_p.L323P	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	375	Cytoplasmic (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		CCCCCACCGCTGAAGCCCAGG	0.637													C	17589233	C	C	17589233	3	2	118	1	0	0	0	0	1	0	0	0	7639	1580	55	4	1174	4	IL17RA	22	17589233	Missense_Mutation	SNP	T	TCGA-12-1597-01B-01D-1495-08		17589233	33715333	78	8142											
APOBEC3A	200315	broad.mit.edu	37	chr22	39355652	39355652	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcctggacaatggcacctcGgtcaagatggaccagcacag	12	13	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr22:39355652G>A	uc003awn.2	+	2	305	c.135G>A	c.(133-135)TCG>TCA	p.S45S	APOBEC3A_uc011aob.1_Silent_p.S27S|APOBEC3A_uc011aoc.1_Silent_p.S45S	NM_145699	NP_663745	P31941	ABC3A_HUMAN	phorbolin 1	45					cellular response to xenobiotic stimulus|defense response to virus|DNA cytosine deamination|DNA demethylation|innate immune response|negative regulation of transposition|negative regulation of viral genome replication	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					ATGGCACCTCGGTCAAGATGG	0.532													A	39355652	A	A	39355652	2	1	118	1	0	0	0	0	0	0	0	1	789	1103	39	2		2	APOBEC3A	22	39355652	Silent	SNP	G	TCGA-12-1597-01B-01D-1495-08	21766419	39355652	11948914	79	8143											
MCAT	27349	broad.mit.edu	37	chr22	43538975	43538975	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcgacagcggccagcgatGccacgaagatcgcgggctga	14	13	1	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chr22:43538975G>A	uc003bdl.1	-	1	429	c.380C>T	c.(379-381)GCA>GTA	p.A127V	MCAT_uc003bdm.1_Missense_Mutation_p.A127V	NM_173467	NP_775738	Q8IVS2	FABD_HUMAN	mitochondrial malonyltransferase isoform a	127					fatty acid biosynthetic process	mitochondrion	[acyl-carrier-protein] S-malonyltransferase activity|binding			ovary(1)	1		Ovarian(80;0.0694)				GGCCAGCGATGCCACGAAGAT	0.682													A	43538975	A	A	43538975	3	1	118	1	0	0	0	0	1	0	0	0	9372	1319	46	3	808	3	MCAT	22	43538975	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	4183323	43538975	7765591	80	8144											
CXorf59	286464	broad.mit.edu	37	chrX	36103466	36103466	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcaattctactcatcaacctCgccaccccaaaagttttcca	3	16	3	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chrX:36103466C>T	uc004ddk.1	+	5	638	c.452C>T	c.(451-453)TCG>TTG	p.S151L		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	151						integral to membrane				central_nervous_system(1)	1						TCATCAACCTCGCCACCCCAA	0.338													T	36103466	T	T	36103466	3	4	118	1	0	0	0	0	1	0	0	0	4115	893	31	2	466	2	CXorf59	23	36103466	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08		36103466	119167094	81	8145											
FAM47C	442444	broad.mit.edu	37	chrX	37028621	37028621	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcccaagactcgggtgtccaGtctccacgcggagcctcctg	11	16	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chrX:37028621G>T	uc004ddl.1	+	1	2152	c.2138G>T	c.(2137-2139)AGT>ATT	p.S713I		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	713										ovary(3)	3						CGGGTGTCCAGTCTCCACGCG	0.647													T	37028621	T	T	37028621	3	4	118	1	0	0	0	0	1	0	0	0	5571	1029	36	5	2140	5	FAM47C	23	37028621	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	925155	37028621	118241939	82	8146											
DGKK	139189	broad.mit.edu	37	chrX	50146548	50146548	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	caatgtattccacttgcagtCtttgcttgctctcaaagcac	6	12	2	0			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chrX:50146548C>A	uc010njr.1	-	6	1186	c.1126G>T	c.(1126-1128)GAC>TAC	p.D376Y		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	376	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					CACTTGCAGTCTTTGCTTGCT	0.458													A	50146548	A	A	50146548	3	1	118	1	0	0	0	0	1	0	0	0	4472	913	32	5	2780	5	DGKK	23	50146548	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	13117927	50146548	105124012	83	8147											
MED12	9968	broad.mit.edu	37	chrX	70342412	70342412	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcaaggagcggggacaggcaGttgaagttcgctggtctttc	15	8	2	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chrX:70342412G>C	uc004dyy.2	+	9	1502	c.1303G>C	c.(1303-1305)GTT>CTT	p.V435L	MED12_uc011mpq.1_Missense_Mutation_p.V435L|MED12_uc004dyz.2_Missense_Mutation_p.V435L|MED12_uc004dza.2_Missense_Mutation_p.V282L	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	435					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GGGACAGGCAGTTGAAGTTCG	0.468													C	70342412	C	C	70342412	3	2	118	1	0	0	0	0	1	0	0	0	9428	1029	36	5	1337	5	MED12	23	70342412	Missense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	20195864	70342412	84928148	84	8148											
FGF16	8823	broad.mit.edu	37	chrX	76711875	76711875	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactcagagagacagtattaCgtggccctgaacaaagatgg	12	8	1	4			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chrX:76711875C>T	uc011mqp.1	+	2	486	c.213C>T	c.(211-213)TAC>TAT	p.Y71Y		NM_003868	NP_003859	O43320	FGF16_HUMAN	fibroblast growth factor 16	162					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|metabolic process|organ morphogenesis|response to temperature stimulus	extracellular space	growth factor activity			lung(1)	1						GACAGTATTACGTGGCCCTGA	0.463													T	76711875	T	T	76711875	2	4	118	1	0	0	0	0	0	0	0	1	5844	547	19	1		1	FGF16	23	76711875	Silent	SNP	C	TCGA-12-1597-01B-01D-1495-08	6369463	76711875	78558685	85	8149											
ATP7A	538	broad.mit.edu	37	chrX	77264612	77264612	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttaacaggtgaggggaatgaCgtgtgcctcctgcgtacata	13	8	0	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chrX:77264612C>T	uc004ecx.3	+	7	1881	c.1721C>T	c.(1720-1722)ACG>ATG	p.T574M	ATP7A_uc004ecw.2_Missense_Mutation_p.T574M	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	574	HMA 6.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						AGGGGAATGACGTGTGCCTCC	0.378													T	77264612	T	T	77264612	3	4	118	1	0	0	0	0	1	0	0	0	1190	536	19	1	1743	1	ATP7A	23	77264612	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	552737	77264612	78005948	86	8150											
TAF7L	54457	broad.mit.edu	37	chrX	100531023	100531023	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ttccactttcatgatgagatCcttctgtctttgtgctttat	6	9	3	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chrX:100531023C>A	uc004ehb.2	-	11	1261	c.1249G>T	c.(1249-1251)GAT>TAT	p.D417Y	TAF7L_uc004eha.2_Missense_Mutation_p.D257Y	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	417	Potential.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						ATGATGAGATCCTTCTGTCTT	0.353													A	100531023	A	A	100531023	3	1	118	1	0	0	0	0	1	0	0	0	15530	855	30	5	151	5	TAF7L	23	100531023	Missense_Mutation	SNP	C	TCGA-12-1597-01B-01D-1495-08	23266411	100531023	54739537	87	8151											
SRPK3	26576	broad.mit.edu	37	chrX	153050273	153050273	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaggtgctgatcggcgccgaAtacggccccccggcagacat	14	14	0	2			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chrX:153050273A>G	uc004fil.2	+	12	1349	c.1317A>G	c.(1315-1317)GAA>GAG	p.E439E	SRPK3_uc004fik.2_Silent_p.E505E|SRPK3_uc010nul.2_Silent_p.E363E|SRPK3_uc004fin.2_Silent_p.E438E|SRPK3_uc004fim.2_Silent_p.E405E	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	439	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TCGGCGCCGAATACGGCCCCC	0.692													G	153050273	G	G	153050273	2	3	118	1	0	0	0	0	0	0	0	1	15160	98	4	4		4	SRPK3	23	153050273	Silent	SNP	A	TCGA-12-1597-01B-01D-1495-08	52519250	153050273	2220287	88	8152											
MTCP1	4515	broad.mit.edu	37	chrX	154294043	154294043	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacctgaatttgctggactcGtgcccttaggaaactcgtct	9	11	1	1			TCGA-12-1597-01B-01D-1495-08	TCGA-12-1597-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d35c610-cc06-4aa5-8c96-2f7b7465069f	ecbbe2f6-d86b-4498-be57-285695ea7eb2	g.chrX:154294043G>A	uc004fmz.2	-	3	753	c.127C>T	c.(127-129)CGA>TGA	p.R43*	MTCP1NB_uc004fmy.2_Intron	NM_001018025	NP_001018025	P56278	MTCP1_HUMAN	mature T-cell proliferation 1	43					cell proliferation					lung(1)	1	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGCTGGACTCGTGCCCTTAGG	0.458			T	TRA@	T cell prolymphocytic leukemia								A	154294043	A	A	154294043	4	1	118	1	0	0	0	0	0	1	0	0	9915	1153	40	1	204	1	MTCP1	23	154294043	Nonsense_Mutation	SNP	G	TCGA-12-1597-01B-01D-1495-08	1243770	154294043	976517	89	8153											
EPHA10	284656	broad.mit.edu	37	chr1	38227382	38227382	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaaccccgccggctgagcGgtccgatctcgcgcacctct	12	17	2	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:38227382G>A	uc009vvi.2	-	3	631	c.545C>T	c.(544-546)CCG>CTG	p.P182L	EPHA10_uc001cbw.3_Missense_Mutation_p.P182L	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	182	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCGGCTGAGCGGTCCGATCTC	0.657													A	38227382	A	A	38227382	3	1	119	1	0	0	0	0	1	0	0	0	5166	1116	39	2	2579	2	EPHA10	1	38227382	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08		38227382	211023239	1	8154											
SLC2A1	6513	broad.mit.edu	37	chr1	43396302	43396302	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgccccagcttacctgggCgatgaggatgccgacgacga	13	14	0	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:43396302C>T	uc001cik.2	-	4	1036	c.511G>A	c.(511-513)GCC>ACC	p.A171T		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	171	Helical; Name=5; (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CTTACCTGGGCGATGAGGATG	0.642													T	43396302	T	T	43396302	3	4	119	1	0	0	0	0	1	0	0	0	14538	768	27	1	995	1	SLC2A1	1	43396302	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	5168920	43396302	205854319	2	8155											
KLF17	128209	broad.mit.edu	37	chr1	44595024	44595024	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgactctttttccccaaGgataacgagaactcagcgcc	7	14	2	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:44595024G>A	uc001clp.2	+	2	140	c.82_splice	c.e2-1	p.D28_splice	KLF17_uc009vxf.1_Splice_Site	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393						regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TTTTCCCCAAGGATAACGAGA	0.483													A	44595024	A	A	44595024	5	1	119	1	0	0	0	0	0	0	1	0	8345	1014	35	3	87	3	KLF17	1	44595024	Splice_Site	SNP	G	TCGA-12-3649-01A-01D-1495-08	1198722	44595024	204655597	3	8156											
EPHX4	253152	broad.mit.edu	37	chr1	92495767	92495767	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaacttttgtggagcctcgGcaaggggccggcgcagacct	14	12	0	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:92495767G>A	uc001don.2	+	1	235	c.131G>A	c.(130-132)GGC>GAC	p.G44D		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	44						integral to membrane	hydrolase activity			central_nervous_system(1)	1						TGGAGCCTCGGCAAGGGGCCG	0.677													A	92495767	A	A	92495767	3	1	119	1	0	0	0	0	1	0	0	0	5182	1203	42	3	133	3	EPHX4	1	92495767	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	47900743	92495767	156754854	4	8157											
NRAS	4893	broad.mit.edu	37	chr1	115256529	115256529	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcatggcactgtactcttctTgtccagctgtatccagtatg	8	11	3	0	rs11554290		TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:115256529T>A	uc009wgu.2	-	3	436	c.182A>T	c.(181-183)CAA>CTA	p.Q61L		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458	Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MHHES1_BONE)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(KU1919_URINARY_TRACT)|Q61L(C3A_LIVER)|Q61R(TT2609C02_THYROID)|Q61R(NCIH2347_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(SW1271_LUNG)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			A	115256529	A	A	115256529	3	1	119	1	0	0	0	0	1	0	0	0	10640	1812	63	5	399	5	NRAS	1	115256529	Missense_Mutation	SNP	T	TCGA-12-3649-01A-01D-1495-08	22760762	115256529	133994092	5	8158											
NBPF10	100132406	broad.mit.edu	37	chr1	145367751	145367751	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aaggggaaaaaaagaaggggAagaagatcaaagaaggaaag	15	1	1	4			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:145367751A>T	uc001end.3	+	85	10607	c.10572A>T	c.(10570-10572)GGA>GGT	p.G3524G	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3449											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		aaagaaggggaagaagatcaa	0.244													T	145367751	T	T	145367751	2	4	119	1	0	0	0	0	0	0	0	1	10193	233	9	5		5	NBPF10	1	145367751	Silent	SNP	A	TCGA-12-3649-01A-01D-1495-08	30111222	145367751	103882870	6	8159											
OR6K2	81448	broad.mit.edu	37	chr1	158669760	158669760	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcctccagctgaatgaataCgtagaattacagccacaata	8	10	0	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:158669760C>T	uc001fsu.1	-	1	683	c.683G>A	c.(682-684)CGT>CAT	p.R228H		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TGAATGAATACGTAGAATTAC	0.453													T	158669760	T	T	158669760	3	4	119	1	0	0	0	0	1	0	0	0	11202	536	19	1	295	1	OR6K2	1	158669760	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	13302009	158669760	90580861	7	8160											
GPR161	23432	broad.mit.edu	37	chr1	168066138	168066138	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggagttcttcctcccggtcCtctgagcatcctcctccacg	8	17	2	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:168066138C>G	uc001gfc.2	-	5	1021	c.707G>C	c.(706-708)AGG>ACG	p.R236T	GPR161_uc001gfb.2_Missense_Mutation_p.R104T|GPR161_uc010pll.1_Missense_Mutation_p.R146T|GPR161_uc010plm.1_Missense_Mutation_p.R122T|GPR161_uc009wvo.2_Missense_Mutation_p.R253T|GPR161_uc001gfd.2_Missense_Mutation_p.R236T|GPR161_uc010pln.1_Missense_Mutation_p.R256T|GPR161_uc001gfe.1_Missense_Mutation_p.R236T	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	236	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					CCTCCCGGTCCTCTGAGCATC	0.597													G	168066138	G	G	168066138	3	3	119	1	0	0	0	0	1	0	0	0	6665	681	24	5	898	5	GPR161	1	168066138	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	9396378	168066138	81184483	8	8161											
CR2	1380	broad.mit.edu	37	chr1	207644110	207644110	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	caggcccctcctaacatcctCaatgggcaaaaggaagatag	9	12	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:207644110C>A	uc001hfw.2	+	7	1345	c.1251C>A	c.(1249-1251)CTC>CTA	p.L417L	CR2_uc001hfv.2_Silent_p.L417L|CR2_uc009xch.2_Silent_p.L417L|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	417	Sushi 7.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						CTAACATCCTCAATGGGCAAA	0.418													A	207644110	A	A	207644110	2	1	119	1	0	0	0	0	0	0	0	1	3842	813	29	5		5	CR2	1	207644110	Silent	SNP	C	TCGA-12-3649-01A-01D-1495-08	39577972	207644110	41606511	9	8162											
LYST	1130	broad.mit.edu	37	chr1	235866229	235866229	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcatggtttctagcgctcGtctctgaactggatcttcaa	8	10	5	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:235866229G>A	uc001hxj.2	-	45	10367	c.10192C>T	c.(10192-10194)CGA>TGA	p.R3398*	LYST_uc001hxi.2_Nonsense_Mutation_p.R622*	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3398	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCTAGCGCTCGTCTCTGAACT	0.453									Chediak-Higashi_syndrome				A	235866229	A	A	235866229	4	1	119	1	0	0	0	0	0	1	0	0	9128	1153	40	1	1249	1	LYST	1	235866229	Nonsense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	28222119	235866229	13384392	10	8163											
RYR2	6262	broad.mit.edu	37	chr1	237777418	237777418	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctccggctctactcagccGtctgtgctcttgggaaccac	9	16	5	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:237777418G>A	uc001hyl.1	+	37	5110	c.4990G>A	c.(4990-4992)GTC>ATC	p.V1664I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1664	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTACTCAGCCGTCTGTGCTCT	0.517													A	237777418	A	A	237777418	3	1	119	1	0	0	0	0	1	0	0	0	13769	1145	40	1	5136	1	RYR2	1	237777418	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	1911189	237777418	11473203	11	8164											
RYR2	6262	broad.mit.edu	37	chr1	237995876	237995876	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cttatgtctggaagatgtatCaagaaaggtgttgggaattt	12	3	2	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr1:237995876C>G	uc001hyl.1	+	105	14953	c.14833C>G	c.(14833-14835)CAA>GAA	p.Q4945E	RYR2_uc010pyb.1_3'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4945					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAGATGTATCAAGAAAGGTG	0.383													G	237995876	G	G	237995876	3	3	119	1	0	0	0	0	1	0	0	0	13769	827	29	5	15251	5	RYR2	1	237995876	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	218458	237995876	11254745	12	8165											
GRHL1	29841	broad.mit.edu	37	chr2	10102621	10102621	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcagtctgcggatgcctgGcatgaattcagaggactatg	12	9	3	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr2:10102621G>A	uc002raa.2	+	5	878	c.707G>A	c.(706-708)GGC>GAC	p.G236D	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Intron|GRHL1_uc010yjb.1_Missense_Mutation_p.G85D	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	236					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		CGGATGCCTGGCATGAATTCA	0.358													A	10102621	A	A	10102621	3	1	119	1	0	0	0	0	1	0	0	0	6763	1203	42	3	725	3	GRHL1	2	10102621	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08		10102621	233096752	13	8166											
CCDC85A	114800	broad.mit.edu	37	chr2	56420095	56420095	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcactccaagcacaggagcGccagccccgagcatccacag	10	17	0	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr2:56420095G>A	uc002rzn.2	+	2	1262	c.760G>A	c.(760-762)GCC>ACC	p.A254T		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	254	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCACAGGAGCGCCAGCCCCGA	0.657													A	56420095	A	A	56420095	3	1	119	1	0	0	0	0	1	0	0	0	2859	1087	38	1	766	1	CCDC85A	2	56420095	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	46317474	56420095	186779278	14	8167											
SULT1C3	442038	broad.mit.edu	37	chr2	108872031	108872031	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctctccttgatttcagattGtctatgtggccagaaatccc	7	12	3	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr2:108872031G>T	uc010ywo.1	+	4	403	c.403G>T	c.(403-405)GTC>TTC	p.V135F		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	135						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						ATTTCAGATTGTCTATGTGGC	0.413													T	108872031	T	T	108872031	3	4	119	1	0	0	0	0	1	0	0	0	15375	1377	48	5	417	5	SULT1C3	2	108872031	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	52451936	108872031	134327342	15	8168											
SLC4A10	57282	broad.mit.edu	37	chr2	162813661	162813661	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cagctccaggagaacaacccAaatttctcggcattcgggag	10	12	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr2:162813661A>T	uc002ubx.3	+	20	2888	c.2704A>T	c.(2704-2706)AAA>TAA	p.K902*	SLC4A10_uc002uby.3_Nonsense_Mutation_p.K872*|SLC4A10_uc010zcs.1_Nonsense_Mutation_p.K883*	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	902	Extracellular (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						AGAACAACCCAAATTTCTCGG	0.448													T	162813661	T	T	162813661	4	4	119	1	0	0	0	0	0	1	0	0	14651	131	5	5	2867	5	SLC4A10	2	162813661	Nonsense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08	53941630	162813661	80385712	16	8169											
SCN9A	6335	broad.mit.edu	37	chr2	167141278	167141278	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctttgaaactaaaaagActtgttctgctgcttcgcct	7	11	1	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr2:167141278A>T	uc010fpl.2	-	12	2000	c.1659T>A	c.(1657-1659)AGT>AGA	p.S553R	uc002udp.2_Intron|SCN9A_uc002udr.1_Missense_Mutation_p.S424R|SCN9A_uc002uds.1_Missense_Mutation_p.S424R|SCN9A_uc002udt.1_Missense_Mutation_p.S424R	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	553						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	AACTAAAAAGACTTGTTCTGC	0.443													T	167141278	T	T	167141278	3	4	119	1	0	0	0	0	1	0	0	0	13925	272	10	5	4338	5	SCN9A	2	167141278	Missense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08	4327617	167141278	76058095	17	8170											
TTN	7273	broad.mit.edu	37	chr2	179456812	179456812	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	actggttgccttcattcagaTgcttagcgaagtgactcttt	9	9	3	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr2:179456812T>A	uc010zfg.1	-	251	52339	c.52115A>T	c.(52114-52116)CAT>CTT	p.H17372L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.H11067L|TTN_uc010zfi.1_Missense_Mutation_p.H11000L|TTN_uc010zfj.1_Missense_Mutation_p.H10875L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18299							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATTCAGATGCTTAGCGAA	0.463													A	179456812	A	A	179456812	3	1	119	1	0	0	0	0	1	0	0	0	16732	1464	51	5	48404	5	TTN	2	179456812	Missense_Mutation	SNP	T	TCGA-12-3649-01A-01D-1495-08	12315534	179456812	63742561	18	8171											
SLC4A7	9497	broad.mit.edu	37	chr3	27431585	27431585	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcattccaaataattttataCggtcaaataactacatatag	4	7	1	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr3:27431585C>T	uc003cdv.2	-	22	3241	c.3170G>A	c.(3169-3171)CGT>CAT	p.R1057H	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.R938H|SLC4A7_uc011aww.1_Missense_Mutation_p.R1066H|SLC4A7_uc011awx.1_Missense_Mutation_p.R1053H|SLC4A7_uc011awy.1_Missense_Mutation_p.R1049H|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.R938H|SLC4A7_uc011axb.1_Missense_Mutation_p.R1053H|SLC4A7_uc010hfl.2_Missense_Mutation_p.R607H|SLC4A7_uc003cdw.2_Missense_Mutation_p.R933H	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	1057	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						TAATTTTATACGGTCAAATAA	0.328													T	27431585	T	T	27431585	3	4	119	1	0	0	0	0	1	0	0	0	14658	536	19	1	490	1	SLC4A7	3	27431585	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08		27431585	170590845	19	8172											
MST1R	4486	broad.mit.edu	37	chr3	49939965	49939965	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgacagagttggggcccaCgccaggaccaccatccttgc	12	15	0	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr3:49939965C>T	uc003cxy.3	-	1	1342	c.1078G>A	c.(1078-1080)GTG>ATG	p.V360M	MST1R_uc011bdd.1_Missense_Mutation_p.V360M|MST1R_uc011bde.1_Missense_Mutation_p.V360M|MST1R_uc011bdf.1_Missense_Mutation_p.V360M|MST1R_uc011bdg.1_Missense_Mutation_p.V360M	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	360	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TTGGGGCCCACGCCAGGACCA	0.587													T	49939965	T	T	49939965	3	4	119	1	0	0	0	0	1	0	0	0	9891	536	19	1	3204	1	MST1R	3	49939965	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	22508380	49939965	148082465	20	8173											
ITIH1	3697	broad.mit.edu	37	chr3	52816072	52816072	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcagtcgagacaagatctgCgacctcctggtgagccctga	12	12	2	4			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr3:52816072C>T	uc003dfs.2	+	7	828	c.804C>T	c.(802-804)TGC>TGT	p.C268C	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_5'Flank|ITIH1_uc010hmo.1_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	268					hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		ACAAGATCTGCGACCTCCTGG	0.587													T	52816072	T	T	52816072	2	4	119	1	0	0	0	0	0	0	0	1	7903	776	27	1		1	ITIH1	3	52816072	Silent	SNP	C	TCGA-12-3649-01A-01D-1495-08	2876107	52816072	145206358	21	8174											
SORCS2	57537	broad.mit.edu	37	chr4	7666134	7666134	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccgagaagatgctgacagCcccattcgcaggccccattg	10	15	0	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr4:7666134C>T	uc003gkb.3	+	7	1007	c.1007C>T	c.(1006-1008)GCC>GTC	p.A336V	SORCS2_uc011bwi.1_Missense_Mutation_p.A164V	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	336	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						ATGCTGACAGCCCCATTCGCA	0.557													T	7666134	T	T	7666134	3	4	119	1	0	0	0	0	1	0	0	0	14931	739	26	3	1033	3	SORCS2	4	7666134	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08		7666134	183488142	22	8175											
GC	2638	broad.mit.edu	37	chr4	72618353	72618353	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catcaggcaattttgcttttAgtcgctctgccagtctgaaa	8	10	3	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr4:72618353A>G	uc003hge.2	-	11	1430	c.1277T>C	c.(1276-1278)CTA>CCA	p.L426P	GC_uc003hgd.2_Missense_Mutation_p.L304P|GC_uc010iie.2_Missense_Mutation_p.L426P|GC_uc010iif.2_Missense_Mutation_p.L445P	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	426	Albumin 3.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TTTTGCTTTTAGTCGCTCTGC	0.388													G	72618353	G	G	72618353	3	3	119	1	0	0	0	0	1	0	0	0	6282	420	15	4	155	4	GC	4	72618353	Missense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08	64952219	72618353	118535923	23	8176											
FAM190A	401145	broad.mit.edu	37	chr4	91230163	91230163	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acgggcaggaagctctttacAatctcctttgctttctgctg	9	11	3	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr4:91230163A>T	uc003hsv.3	+	2	1068	c.728A>T	c.(727-729)CAA>CTA	p.Q243L	FAM190A_uc003hsu.3_Missense_Mutation_p.Q243L|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.Q243L	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	243										large_intestine(1)|ovary(1)	2						AGCTCTTTACAATCTCCTTTG	0.418													T	91230163	T	T	91230163	3	4	119	1	0	0	0	0	1	0	0	0	5521	130	5	5	730	5	FAM190A	4	91230163	Missense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08	18611810	91230163	99924113	24	8177											
C4orf21	55345	broad.mit.edu	37	chr4	113481967	113481967	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttcatgtgatgccatcatttGagctatttgaattagagctg	9	6	2	4			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr4:113481967G>T	uc003iau.2	-	19	5093	c.4882C>A	c.(4882-4884)CAA>AAA	p.Q1628K	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Missense_Mutation_p.Q86K	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	450						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GCCATCATTTGAGCTATTTGA	0.378													T	113481967	T	T	113481967	3	4	119	1	0	0	0	0	1	0	0	0	2254	1299	45	5	1472	5	C4orf21	4	113481967	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	22251804	113481967	77672309	25	8178											
ANK2	287	broad.mit.edu	37	chr4	114251469	114251469	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gatgcagacacaatgggctcCgaatcattattccacctcgg	9	12	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr4:114251469C>G	uc003ibe.3	+	27	3068	c.2968C>G	c.(2968-2970)CGA>GGA	p.R990G	ANK2_uc003ibd.3_Missense_Mutation_p.R981G|ANK2_uc003ibf.3_Missense_Mutation_p.R990G|ANK2_uc011cgc.1_Missense_Mutation_p.R199G|ANK2_uc003ibg.3_Missense_Mutation_p.R18G|ANK2_uc003ibc.2_Missense_Mutation_p.R966G|ANK2_uc011cgb.1_Missense_Mutation_p.R1005G	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	990	ZU5.|Interaction with SPTBN1.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAATGGGCTCCGAATCATTAT	0.473													G	114251469	G	G	114251469	3	3	119	1	0	0	0	0	1	0	0	0	621	644	23	5	3139	5	ANK2	4	114251469	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	769502	114251469	76902807	26	8179											
C4orf43	55319	broad.mit.edu	37	chr4	164415798	164415798	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggggacgctttagagaaaCgcactcgcctctcctgttcc	10	14	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr4:164415798C>T	uc003iqq.3	+	1	126	c.-155C>T	c.(-157--153)AACGC>AATGC			NM_018352	NP_060822	Q96EY4	CD043_HUMAN	hypothetical protein LOC55319												0						TTTAGAGAAACGCACTCGCCT	0.632													T	164415798	T	T	164415798	1	4	119	1	0	0	0	0	0	0	0	0	2271	551	19	1		1	C4orf43	4	164415798	Translation_Start_Site	SNP	C	TCGA-12-3649-01A-01D-1495-08	50164329	164415798	26738478	27	8180											
MYO10	4651	broad.mit.edu	37	chr5	16769271	16769271	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaagcagcctcgacacttcCcgaacttcctccttgctgaa	7	16	0	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr5:16769271C>T	uc003jft.3	-	10	1440	c.972G>A	c.(970-972)CGG>CGA	p.R324R	MYO10_uc010itx.2_5'Flank	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	324	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TCGACACTTCCCGAACTTCCT	0.413													T	16769271	T	T	16769271	2	4	119	1	0	0	0	0	0	0	0	1	10062	610	22	3		3	MYO10	5	16769271	Silent	SNP	C	TCGA-12-3649-01A-01D-1495-08		16769271	164145989	28	8181											
TSSK1B	83942	broad.mit.edu	37	chr5	112769636	112769636	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttcttgtcagagccaggttCgggggtccacaagggttcag	14	10	3	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr5:112769636C>T	uc003kqm.2	-	1	1093	c.901G>A	c.(901-903)GAA>AAA	p.E301K	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	301					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		GAGCCAGGTTCGGGGGTCCAC	0.622													T	112769636	T	T	112769636	3	4	119	1	0	0	0	0	1	0	0	0	16665	893	31	2	206	2	TSSK1B	5	112769636	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	96000365	112769636	68145624	29	8182											
PCDHGA1	56114	broad.mit.edu	37	chr5	140711854	140711854	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaactgaaagtgatggcgCgggacagtggggatccgccc	16	10	0	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr5:140711854C>T	uc003lji.1	+	1	1603	c.1603C>T	c.(1603-1605)CGG>TGG	p.R535W	PCDHGA1_uc011dan.1_Missense_Mutation_p.R535W	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	535	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGATGGCGCGGGACAGTGG	0.602													T	140711854	T	T	140711854	3	4	119	1	0	0	0	0	1	0	0	0	11550	759	27	1	1605	1	PCDHGA1	5	140711854	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	27942218	140711854	40203406	30	8183											
FBXO38	81545	broad.mit.edu	37	chr5	147782003	147782003	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaatttcgtaatcgtaatggAgcttttccaattcctcctga	6	9	0	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr5:147782003A>G	uc003lpf.1	+	5	639	c.519A>G	c.(517-519)GGA>GGG	p.G173G	FBXO38_uc003lpg.1_Silent_p.G173G|FBXO38_uc003lph.2_Silent_p.G173G	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	173						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCGTAATGGAGCTTTTCCAA	0.363													G	147782003	G	G	147782003	2	3	119	1	0	0	0	0	0	0	0	1	5746	291	11	4		4	FBXO38	5	147782003	Silent	SNP	A	TCGA-12-3649-01A-01D-1495-08	7070149	147782003	33133257	31	8184											
EXOC2	55770	broad.mit.edu	37	chr6	619481	619481	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctgctgagaaattctcaCttgtaaaatcagcactcatt	7	9	3	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr6:619481C>T	uc003mtd.2	-	5	619	c.485G>A	c.(484-486)AGT>AAT	p.S162N	EXOC2_uc003mte.2_Missense_Mutation_p.S162N|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	162					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GAAATTCTCACTTGTAAAATC	0.378													T	619481	T	T	619481	3	4	119	1	0	0	0	0	1	0	0	0	5302	565	20	3	2385	3	EXOC2	6	619481	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08		619481	170495586	32	8185											
HLA-DQA2	3118	broad.mit.edu	37	chr6	32713607	32713607	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttttccaagtttcctgtgaCgctgggtcagcccaacaccc	9	14	1	1	rs144060347		TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr6:32713607C>T	uc003obx.2	+	3	429	c.371C>T	c.(370-372)ACG>ATG	p.T124M		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	124	Alpha-2.|Extracellular (Potential).|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTCCTGTGACGCTGGGTCAG	0.507													T	32713607	T	T	32713607	3	4	119	1	0	0	0	0	1	0	0	0	7205	536	19	1	381	1	HLA-DQA2	6	32713607	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	32094126	32713607	138401460	33	8186											
BRPF3	27154	broad.mit.edu	37	chr6	36175096	36175096	+	Frame_Shift_Del	DEL	C	-	-													cttccctcctgtagcgagagCaggatgagaagacaagtgca							TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr6:36175096delC	uc003olv.3	+	4	1836	c.1612delC	c.(1612-1614)CAGfs	p.Q538fs	BRPF3_uc010jwb.2_Frame_Shift_Del_p.Q538fs|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Frame_Shift_Del_p.Q538fs	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	538					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GTAGCGAGAGCAGGATGAGAA	0.547													-	36175096	-	-	36175096	7	5	119	1	0	1	0	1	0	0	0	0	1521	711	25	0	1622	0	BRPF3	6	36175096	Frame_Shift_Del	DEL	C	TCGA-12-3649-01A-01D-1495-08	3461489	36175096	134939971	34	8187											
BMP5	653	broad.mit.edu	37	chr6	55620351	55620351	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttagtggcagccacatgagcGtactaccatatttctatatt	7	9	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr6:55620351G>A	uc003pcq.2	-	7	2057	c.1345C>T	c.(1345-1347)CGC>TGC	p.R449C	BMP5_uc011dxf.1_Missense_Mutation_p.R412C	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	449					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CCACATGAGCGTACTACCATA	0.328													A	55620351	A	A	55620351	3	1	119	1	0	0	0	0	1	0	0	0	1463	1145	40	1	23	1	BMP5	6	55620351	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	19445255	55620351	115494716	35	8188											
C6orf167	253714	broad.mit.edu	37	chr6	97613246	97613246	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtgaagctggaagaaatcGcccaatatactgctcaataa	9	8	1	2	rs146474162	by1000genomes	TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr6:97613246G>A	uc003ppb.2	-	21	3363	c.3097C>T	c.(3097-3099)CGA>TGA	p.R1033*	C6orf167_uc011eaf.1_Nonsense_Mutation_p.R993*	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	1033					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		GGAAGAAATCGCCCAATATAC	0.393													A	97613246	A	A	97613246	4	1	119	1	0	0	0	0	0	1	0	0	2342	1095	38	1	654	1	C6orf167	6	97613246	Nonsense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	41992895	97613246	73501821	36	8189											
GRIK2	2898	broad.mit.edu	37	chr6	102483322	102483322	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aatccagcgagtcctcacctCtgattatgctttcctaatgg	7	12	2	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr6:102483322C>G	uc003pqp.3	+	14	2441	c.2192C>G	c.(2191-2193)TCT>TGT	p.S731C	GRIK2_uc003pqo.3_Missense_Mutation_p.S731C|GRIK2_uc010kcw.2_Missense_Mutation_p.S731C	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	731	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GTCCTCACCTCTGATTATGCT	0.443													G	102483322	G	G	102483322	3	3	119	1	0	0	0	0	1	0	0	0	6774	913	32	5	2246	5	GRIK2	6	102483322	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	4870076	102483322	68631745	37	8190											
PCLO	27445	broad.mit.edu	37	chr7	82508670	82508670	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccttccataagcttccccGtctgttccgcacttccccca	4	19	1	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr7:82508670G>A	uc003uhx.2	-	10	13926	c.13637C>T	c.(13636-13638)ACG>ATG	p.T4546M	PCLO_uc003uhv.2_Missense_Mutation_p.T4546M|PCLO_uc003uht.1_Translation_Start_Site|PCLO_uc003uhu.1_Translation_Start_Site	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AAGCTTCCCCGTCTGTTCCGC	0.358													A	82508670	A	A	82508670	3	1	119	1	0	0	0	0	1	0	0	0	11583	1145	40	1	1872	1	PCLO	7	82508670	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08		82508670	76629993	38	8191											
CSMD1	64478	broad.mit.edu	37	chr8	4277522	4277522	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactcacagcgaagtctgtcGtgaaccacagagtgaggata	11	10	2	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr8:4277522G>A	uc011kwk.1	-	3	758	c.368C>T	c.(367-369)ACG>ATG	p.T123M		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	123	Extracellular (Potential).|CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GAAGTCTGTCGTGAACCACAG	0.403													A	4277522	A	A	4277522	3	1	119	1	0	0	0	0	1	0	0	0	3944	1145	40	1	10411	1	CSMD1	8	4277522	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08		4277522	142086500	39	8192											
ADAM7	8756	broad.mit.edu	37	chr8	24357714	24357714	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gatggccacggactccagtgCcactgtgaggaaggacaggc	15	11	0	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr8:24357714C>A	uc003xeb.2	+	18	2060	c.1947C>A	c.(1945-1947)TGC>TGA	p.C649*	ADAM7_uc003xec.2_Nonsense_Mutation_p.C421*	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	649	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		gaCTCCAGTGCCACTGTGAGG	0.328													A	24357714	A	A	24357714	4	1	119	1	0	0	0	0	0	1	0	0	251	747	26	5	2017	5	ADAM7	8	24357714	Nonsense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	20080192	24357714	122006308	40	8193											
XKR9	389668	broad.mit.edu	37	chr8	71646034	71646034	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttttttgttttgtagatgCggccatcatggtctcttgct	9	7	2	1	rs140711820		TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr8:71646034C>T	uc003xyq.2	+	5	1031	c.497C>T	c.(496-498)GCG>GTG	p.A166V	XKR9_uc010lze.2_Missense_Mutation_p.A166V|XKR9_uc010lzd.2_Missense_Mutation_p.A34V	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	166	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			TTTGTAGATGCGGCCATCATG	0.274													T	71646034	T	T	71646034	3	4	119	1	0	0	0	0	1	0	0	0	17435	768	27	1	507	1	XKR9	8	71646034	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	47288320	71646034	74717988	41	8194											
GLIS3	169792	broad.mit.edu	37	chr9	4117963	4117963	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcgtacagggcgctgcagtcGatccagcggcagcaatgctt	13	12	0	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr9:4117963G>A	uc003zhw.1	-	3	1244	c.1050C>T	c.(1048-1050)ATC>ATT	p.I350I	GLIS3_uc003zhx.1_Silent_p.I505I|GLIS3_uc003zic.1_Silent_p.I505I|GLIS3_uc003zie.1_Silent_p.I505I|GLIS3_uc010mhh.1_Silent_p.I380I|GLIS3_uc003zid.1_Silent_p.I283I|GLIS3_uc010mhi.1_Silent_p.I312I|GLIS3_uc003zif.1_Silent_p.I283I|GLIS3_uc003zig.1_Silent_p.I349I|GLIS3_uc003zih.1_Silent_p.I283I|GLIS3_uc003zhy.1_Silent_p.I283I|GLIS3_uc003zhz.1_Silent_p.I283I|GLIS3_uc003zib.1_Silent_p.I349I|GLIS3_uc010mhg.1_Silent_p.I283I	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	350	C2H2-type 1.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		CGCTGCAGTCGATCCAGCGGC	0.667													A	4117963	A	A	4117963	2	1	119	1	0	0	0	0	0	0	0	1	6447	1048	37	2		2	GLIS3	9	4117963	Silent	SNP	G	TCGA-12-3649-01A-01D-1495-08		4117963	137095468	42	8195											
TESK1	7016	broad.mit.edu	37	chr9	35609198	35609198	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcccccgagctcccccgccGtatggagacagcactgccag	10	18	0	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr9:35609198G>A	uc003zxa.2	+	10	1676	c.1340G>A	c.(1339-1341)CGT>CAT	p.R447H	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Missense_Mutation_p.R287H	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	447					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTCCCCCGCCGTATGGAGACA	0.687													A	35609198	A	A	35609198	3	1	119	1	0	0	0	0	1	0	0	0	15764	1145	40	1	1378	1	TESK1	9	35609198	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	31491235	35609198	105604233	43	8196											
FBP2	8789	broad.mit.edu	37	chr9	97333806	97333806	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccaccagggttgcactacCgtacagcgcataacctgcgg	11	14	0	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr9:97333806C>T	uc004auv.2	-	4	572	c.505G>A	c.(505-507)GGT>AGT	p.G169S	uc004auu.2_Intron	NM_003837	NP_003828	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	169					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)				GTTGCACTACCGTACAGCGCA	0.552													T	97333806	T	T	97333806	3	4	119	1	0	0	0	0	1	0	0	0	5706	652	23	2	530	2	FBP2	9	97333806	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	61724608	97333806	43879625	44	8197											
USP20	10868	broad.mit.edu	37	chr9	132638480	132638480	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtggagatcgaggcactggCcaagcgcaggaggatcgaga	18	8	0	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr9:132638480C>T	uc004bys.2	+	22	2583	c.2372C>T	c.(2371-2373)GCC>GTC	p.A791V	USP20_uc004byr.2_Missense_Mutation_p.A791V|USP20_uc004byt.1_Missense_Mutation_p.A791V	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	791	DUSP 2.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				GAGGCACTGGCCAAGCGCAGG	0.677													T	132638480	T	T	132638480	3	4	119	1	0	0	0	0	1	0	0	0	17049	739	26	3	2450	3	USP20	9	132638480	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	35304674	132638480	8574951	45	8198											
CUBN	8029	broad.mit.edu	37	chr10	17146591	17146591	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcacacttacaaaaataaCcagagacagtgtcctaaggg	8	9	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr10:17146591C>T	uc001ioo.2	-	12	1296	c.1244G>A	c.(1243-1245)GGT>GAT	p.G415D		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	415	EGF-like 6.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACAAAAATAACCAGAGACAGT	0.373													T	17146591	T	T	17146591	3	4	119	1	0	0	0	0	1	0	0	0	4051	507	18	3	9851	3	CUBN	10	17146591	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08		17146591	118388156	46	8199											
TMEM26	219623	broad.mit.edu	37	chr10	63170497	63170497	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acagacacagggcacacaacGttctgtactgaaaacacaag	8	11	1	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr10:63170497G>T	uc001jlo.2	-	6	1059	c.690C>A	c.(688-690)AAC>AAA	p.N230K	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlp.1_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	230						integral to membrane					0	Prostate(12;0.0112)					GGCACACAACGTTCTGTACTG	0.473													T	63170497	T	T	63170497	3	4	119	1	0	0	0	0	1	0	0	0	16148	1136	40	5	420	5	TMEM26	10	63170497	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	46023906	63170497	72364250	47	8200											
PTEN	5728	broad.mit.edu	37	chr10	89725042	89725042	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attttaaattttctttctctAggtgaagctgtacttcacaa	5	7	3	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr10:89725042A>G	uc001kfb.2	+	10	2058	c.1027_splice	c.e10-2	p.V343_splice		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(6)|p.R55fs*1(4)|p.Y27fs*1(2)|p.N212fs*1(2)|p.G165_*404del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTCTTTCTCTAGGTGAAGCTG	0.333		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			G	89725042	G	G	89725042	5	3	119	1	0	0	0	0	0	0	1	0	12738	434	15	4	1059	4	PTEN	10	89725042	Splice_Site	SNP	A	TCGA-12-3649-01A-01D-1495-08	26554545	89725042	45809705	48	8201											
CHRNA10	57053	broad.mit.edu	37	chr11	3687643	3687643	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctcccctctttcccgcacGcacaggccccgtgccaggtg	11	19	1	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr11:3687643G>A	uc001lyf.2	-	5	1119	c.1047C>T	c.(1045-1047)TGC>TGT	p.C349C	CHRNA10_uc010qxt.1_Silent_p.C143C|CHRNA10_uc010qxu.1_Silent_p.C143C	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	349	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	TTTCCCGCACGCACAGGCCCC	0.667													A	3687643	A	A	3687643	2	1	119	1	0	0	0	0	0	0	0	1	3382	1079	38	1		1	CHRNA10	11	3687643	Silent	SNP	G	TCGA-12-3649-01A-01D-1495-08		3687643	131318873	49	8202											
OR52I2	143502	broad.mit.edu	37	chr11	4608268	4608268	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttaggaaacaccatcatcGtgactgcaatctggatggat	10	8	2	1	rs138555035		TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr11:4608268G>A	uc010qyh.1	+	1	226	c.226G>A	c.(226-228)GTG>ATG	p.V76M		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	76	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACCATCATCGTGACTGCAAT	0.507													A	4608268	A	A	4608268	3	1	119	1	0	0	0	0	1	0	0	0	11121	1145	40	1	228	1	OR52I2	11	4608268	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	920625	4608268	130398248	50	8203											
OR52I1	390037	broad.mit.edu	37	chr11	4615416	4615416	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttaggaaacaccctcatcGtgactgcaatctggatggat	10	9	2	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr11:4615416G>A	uc010qyi.1	+	1	148	c.148G>A	c.(148-150)GTG>ATG	p.V50M		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	50	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACCCTCATCGTGACTGCAAT	0.517													A	4615416	A	A	4615416	3	1	119	1	0	0	0	0	1	0	0	0	11120	1145	40	1	150	1	OR52I1	11	4615416	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	7148	4615416	130391100	51	8204											
OR52H1	390067	broad.mit.edu	37	chr11	5566723	5566723	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggattgtaactgctcaggtTgaaaatgatcatggcagagg	13	5	2	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr11:5566723T>G	uc010qzh.1	-	1	31	c.31A>C	c.(31-33)AAC>CAC	p.N11H	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGCTCAGGTTGAAAATGATC	0.443													G	5566723	G	G	5566723	3	3	119	1	0	0	0	0	1	0	0	0	11119	1812	63	5	934	5	OR52H1	11	5566723	Missense_Mutation	SNP	T	TCGA-12-3649-01A-01D-1495-08	951307	5566723	129439793	52	8205											
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5626645	5626645	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctagacagagtggagcaaCgggagctgaaaaagctggaa	14	7	0	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr11:5626645C>T	uc001mbf.2	+	4	926	c.682C>T	c.(682-684)CGG>TGG	p.R228W	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_Missense_Mutation_p.R174W|TRIM6_uc010qzj.1_Missense_Mutation_p.R25W|TRIM6_uc001mbc.1_Missense_Mutation_p.R200W|TRIM6_uc001mbe.2_Missense_Mutation_p.R25W|TRIM6_uc010qzk.1_Missense_Mutation_p.R25W|TRIM6_uc010qzl.1_Missense_Mutation_p.R25W|TRIM6_uc001mbd.2_Missense_Mutation_p.R228W|TRIM6_uc001mbg.1_Missense_Mutation_p.R25W|TRIM6_uc009yep.1_Missense_Mutation_p.R25W	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	228						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		AGTGGAGCAACGGGAGCTGAA	0.488											OREG0003723	type=REGULATORY REGION|Gene=TRIM6|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	T	5626645	T	T	5626645	3	4	119	1	0	0	0	0	1	0	0	0	16531	527	19	1	696	1	TRIM6-TRIM34	11	5626645	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	59922	5626645	129379871	53	8206											
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5631406	5631406	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaccctgaggaagccagaaGctctccctacaaagctgaga	11	12	1	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr11:5631406G>A	uc001mbf.2	+	6	1133	c.889G>A	c.(889-891)GCT>ACT	p.A297T	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_Missense_Mutation_p.A243T|TRIM6_uc010qzj.1_Missense_Mutation_p.A94T|TRIM6_uc001mbc.1_Missense_Mutation_p.A269T|TRIM6_uc001mbe.2_Missense_Mutation_p.A94T|TRIM6_uc010qzk.1_Missense_Mutation_p.A94T|TRIM6_uc010qzl.1_Missense_Mutation_p.A94T|TRIM6_uc001mbd.2_Missense_Mutation_p.A297T|TRIM6_uc001mbg.1_Missense_Mutation_p.A94T|TRIM6_uc009yep.1_Missense_Mutation_p.A94T	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	297						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		GAAGCCAGAAGCTCTCCCTAC	0.517													A	5631406	A	A	5631406	3	1	119	1	0	0	0	0	1	0	0	0	16531	971	34	3	911	3	TRIM6-TRIM34	11	5631406	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	4761	5631406	129375110	54	8207											
MTNR1B	4544	broad.mit.edu	37	chr11	92714701	92714701	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcgtggccatcttctatgaCggctgggccctgggggagga	16	11	2	1	rs139515067		TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr11:92714701C>T	uc001pdk.1	+	2	415	c.312C>T	c.(310-312)GAC>GAT	p.D104D		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	104	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	TCTTCTATGACGGCTGGGCCC	0.567													T	92714701	T	T	92714701	2	4	119	1	0	0	0	0	0	0	0	1	9952	535	19	1		1	MTNR1B	11	92714701	Silent	SNP	C	TCGA-12-3649-01A-01D-1495-08	87083295	92714701	42291815	55	8208											
OR8A1	390275	broad.mit.edu	37	chr11	124440668	124440668	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aacagttcttgtttcttacaCcttcattctctccagcatcc	3	14	4	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr11:124440668C>A	uc010san.1	+	1	704	c.704C>A	c.(703-705)ACC>AAC	p.T235N		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	235	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GTTTCTTACACCTTCATTCTC	0.493													A	124440668	A	A	124440668	3	1	119	1	0	0	0	0	1	0	0	0	11225	507	18	5	706	5	OR8A1	11	124440668	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	31725967	124440668	10565848	56	8209											
PLEKHA5	54477	broad.mit.edu	37	chr12	19436597	19436597	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcagggatactcccctcaacGaacttacagatcggaagtgt	9	11	2	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr12:19436597G>A	uc001reb.2	+	11	1765	c.1679G>A	c.(1678-1680)CGA>CAA	p.R560Q	PLEKHA5_uc010sie.1_Missense_Mutation_p.R566Q|PLEKHA5_uc001rea.2_Missense_Mutation_p.R560Q|PLEKHA5_uc009zin.2_Missense_Mutation_p.R318Q|PLEKHA5_uc010sif.1_Missense_Mutation_p.R452Q|PLEKHA5_uc010sig.1_Missense_Mutation_p.R452Q|PLEKHA5_uc010sih.1_Missense_Mutation_p.R452Q|PLEKHA5_uc001rec.1_Missense_Mutation_p.R248Q	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	560							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					TCCCCTCAACGAACTTACAGA	0.468													A	19436597	A	A	19436597	3	1	119	1	0	0	0	0	1	0	0	0	12059	1058	37	2	1721	2	PLEKHA5	12	19436597	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08		19436597	114415298	57	8210											
ZFC3H1	196441	broad.mit.edu	37	chr12	72030416	72030416	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aactggaggtgaaggtgggtCactattactggatgtttcct	13	6	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr12:72030416C>G	uc001swo.2	-	9	2313	c.1954G>C	c.(1954-1956)GAC>CAC	p.D652H		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	652					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GAAGGTGGGTCACTATTACTG	0.363													G	72030416	G	G	72030416	3	3	119	1	0	0	0	0	1	0	0	0	17630	826	29	5	4123	5	ZFC3H1	12	72030416	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	52593819	72030416	61821479	58	8211											
C12orf50	160419	broad.mit.edu	37	chr12	88388465	88388466	+	Frame_Shift_Del	DEL	TA	-	-													ttcccatgcaatgatgttttTatttcaccttgcctttcata							TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr12:88388465_88388466delTA	uc001tam.1	-	7	704_705	c.536_537delTA	c.(535-537)ATAfs	p.I179fs	C12orf50_uc001tan.2_Frame_Shift_Del_p.I233fs	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	179										skin(2)|ovary(1)	3						ATGATGTTTTTATTTCACCTTG	0.347													-	88388466	-	-	88388465	7	5	119	1	0	1	0	1	0	0	0	0	1695	1744	61	0	735	0	C12orf50	12	88388465	Frame_Shift_Del	DEL	TA	TCGA-12-3649-01A-01D-1495-08	16358049	88388465	45463430	59	8212											
CCDC60	160777	broad.mit.edu	37	chr12	119966451	119966451	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagaggtatccagaagttcCgtgcttttgtccttgtctca	10	9	1	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr12:119966451C>T	uc001txe.2	+	12	1726	c.1261C>T	c.(1261-1263)CGT>TGT	p.R421C	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	421										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CCAGAAGTTCCGTGCTTTTGT	0.428													T	119966451	T	T	119966451	3	4	119	1	0	0	0	0	1	0	0	0	2831	652	23	2	1307	2	CCDC60	12	119966451	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	31577986	119966451	13885444	60	8213											
GCN1L1	10985	broad.mit.edu	37	chr12	120599767	120599767	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgcgtcaccaggcgcagtgcAgggttctgcacggaggcagt	16	12	2	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr12:120599767A>T	uc001txo.2	-	21	2272	c.2259T>A	c.(2257-2259)CCT>CCA	p.P753P		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	753					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCGCAGTGCAGGGTTCTGCA	0.592													T	120599767	T	T	120599767	2	4	119	1	0	0	0	0	0	0	0	1	6299	175	7	5		5	GCN1L1	12	120599767	Silent	SNP	A	TCGA-12-3649-01A-01D-1495-08	633316	120599767	13252128	61	8214											
TUBA3C	7278	broad.mit.edu	37	chr13	19751200	19751200	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggccatgtacttgccgtggCgagggtcacacttgaccatc	12	12	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr13:19751200C>T	uc009zzj.2	-	4	972	c.923G>A	c.(922-924)CGC>CAC	p.R308H		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	308					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CTTGCCGTGGCGAGGGTCACA	0.587													T	19751200	T	T	19751200	3	4	119	1	0	0	0	0	1	0	0	0	16743	768	27	1	437	1	TUBA3C	13	19751200	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08		19751200	95418678	62	8215											
KLHL1	57626	broad.mit.edu	37	chr13	70681808	70681808	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaatgtgcttcacatcgaaGtcttttcgcccagagcctga	9	11	2	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr13:70681808G>T	uc001vip.2	-	1	818	c.24C>A	c.(22-24)GAC>GAA	p.D8E	KLHL1_uc010thm.1_Missense_Mutation_p.D8E|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	8					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TCACATCGAAGTCTTTTCGCC	0.632													T	70681808	T	T	70681808	3	4	119	1	0	0	0	0	1	0	0	0	8365	1020	36	5	2266	5	KLHL1	13	70681808	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	50930608	70681808	44488070	63	8216											
CLN5	1203	broad.mit.edu	37	chr13	77570066	77570066	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catgatgccattggattcagAagtacattaactggcaagaa	9	7	1	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr13:77570066A>G	uc001vkc.2	+	3	544	c.516A>G	c.(514-516)AGA>AGG	p.R172R		NM_006493	NP_006484	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	123					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		TTGGATTCAGAAGTACATTAA	0.413													G	77570066	G	G	77570066	2	3	119	1	0	0	0	0	0	0	0	1	3544	243	9	4		4	CLN5	13	77570066	Silent	SNP	A	TCGA-12-3649-01A-01D-1495-08	6888258	77570066	37599812	64	8217											
SUPT16H	11198	broad.mit.edu	37	chr14	21822688	21822688	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtactccttctgtgtatttcAggtcgcaggaactaagagaa	10	8	2	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr14:21822688A>G	uc001wao.2	-	23	3011	c.2672T>C	c.(2671-2673)CTG>CCG	p.L891P	SUPT16H_uc001wan.2_Missense_Mutation_p.L35P	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	891					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TGTGTATTTCAGGTCGCAGGA	0.338													G	21822688	G	G	21822688	3	3	119	1	0	0	0	0	1	0	0	0	15393	188	7	4	487	4	SUPT16H	14	21822688	Missense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08		21822688	85526852	65	8218											
SIPA1L1	26037	broad.mit.edu	37	chr14	72055814	72055814	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	agggagatgataaaagcaatGagcttgtaatgagctgtcca	12	5	0	4			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr14:72055814G>A	uc001xms.2	+	2	1573	c.1225G>A	c.(1225-1227)GAG>AAG	p.E409K	SIPA1L1_uc001xmt.2_Missense_Mutation_p.E409K|SIPA1L1_uc001xmu.2_Missense_Mutation_p.E409K|SIPA1L1_uc001xmv.2_Missense_Mutation_p.E409K	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	409					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TAAAAGCAATGAGCTTGTAAT	0.458													A	72055814	A	A	72055814	3	1	119	1	0	0	0	0	1	0	0	0	14329	1291	45	3	1227	3	SIPA1L1	14	72055814	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	50233126	72055814	35293726	66	8219											
C14orf115	55237	broad.mit.edu	37	chr14	74823988	74823988	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaaggcctcctgtttccccAgcagcttctccaacgtgtgg	9	15	2	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr14:74823988A>G	uc001xpw.3	+	2	693	c.502A>G	c.(502-504)AGC>GGC	p.S168G		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	168					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		CTGTTTCCCCAGCAGCTTCTC	0.597													G	74823988	G	G	74823988	3	3	119	1	0	0	0	0	1	0	0	0	1740	188	7	4	504	4	C14orf115	14	74823988	Missense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08	2768174	74823988	32525552	67	8220											
CALM1	801	broad.mit.edu	37	chr14	90870850	90870850	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgatggagacggacaagtcaActatgaaggtaaaactaaat	10	5	1	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr14:90870850A>G	uc001xyl.1	+	5	615	c.413A>G	c.(412-414)AAC>AGC	p.N138S	CALM1_uc010atq.1_Missense_Mutation_p.N139S|CALM1_uc010atr.1_RNA|CALM1_uc001xym.1_Missense_Mutation_p.N102S	NM_006888	NP_008819	P62158	CALM_HUMAN	calmodulin 1 isoform 1	138	4.|EF-hand 4.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			central_nervous_system(1)	1		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.208)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	GGACAAGTCAACTATGAAGGT	0.383													G	90870850	G	G	90870850	3	3	119	1	0	0	0	0	1	0	0	0	2584	43	2	4	431	4	CALM1	14	90870850	Missense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08	16046862	90870850	16478690	68	8221											
PPP4R4	57718	broad.mit.edu	37	chr14	94700063	94700063	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttagttagttgtaaaatttTaggaaaattgaccaacaaat	6	3	0	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr14:94700063T>A	uc001ycs.1	+	6	744	c.590T>A	c.(589-591)TTA>TAA	p.L197*		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	197						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TGTAAAATTTTAGGAAAATTG	0.308													A	94700063	A	A	94700063	4	1	119	1	0	0	0	0	0	1	0	0	12405	1764	61	5	685	5	PPP4R4	14	94700063	Nonsense_Mutation	SNP	T	TCGA-12-3649-01A-01D-1495-08	3829213	94700063	12649477	69	8222											
SERPINA11	256394	broad.mit.edu	37	chr14	94909543	94909543	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagaaattgaaaaccttgGcaagtgcaaatccaacagac	7	10	0	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr14:94909543G>A	uc001ydd.1	-	4	997	c.937C>T	c.(937-939)CCA>TCA	p.P313S		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	313					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		GAAAACCTTGGCAAGTGCAAA	0.458													A	94909543	A	A	94909543	3	1	119	1	0	0	0	0	1	0	0	0	14088	1203	42	3	339	3	SERPINA11	14	94909543	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	209480	94909543	12439997	70	8223											
JAG2	3714	broad.mit.edu	37	chr14	105612833	105612833	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagcaggatctcccgaacccGatcactgtggggagaagggg	15	11	2	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr14:105612833G>A	uc001yqg.2	-	22	3002	c.2598C>T	c.(2596-2598)ATC>ATT	p.I866I	JAG2_uc010axf.2_5'UTR|JAG2_uc001yqf.2_Silent_p.I270I|JAG2_uc001yqh.2_Silent_p.I828I	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	866	Extracellular (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TCCCGAACCCGATCACTGTGG	0.682													A	105612833	A	A	105612833	2	1	119	1	0	0	0	0	0	0	0	1	7935	1048	37	2		2	JAG2	14	105612833	Silent	SNP	G	TCGA-12-3649-01A-01D-1495-08	10703290	105612833	1736707	71	8224											
JAG2	3714	broad.mit.edu	37	chr14	105618019	105618019	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtggcattcgaagccggacGgcacctcatggcaagagccc	13	13	1	1	rs140813175		TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr14:105618019G>A	uc001yqg.2	-	8	1501	c.1097C>T	c.(1096-1098)CCG>CTG	p.P366L	JAG2_uc001yqf.2_5'Flank|JAG2_uc001yqh.2_Missense_Mutation_p.P366L	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	366	EGF-like 4.|Extracellular (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		GAAGCCGGACGGCACCTCATG	0.667													A	105618019	A	A	105618019	3	1	119	1	0	0	0	0	1	0	0	0	7935	1116	39	2	2695	2	JAG2	14	105618019	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	5186	105618019	1731521	72	8225											
SLC27A2	11001	broad.mit.edu	37	chr15	50494831	50494831	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgattggcattcacggatGtattgtggctggtaagcttt	12	6	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr15:50494831G>A	uc001zxw.2	+	3	1068	c.836G>A	c.(835-837)TGT>TAT	p.C279Y	SLC27A2_uc010bes.2_Intron|SLC27A2_uc001zxx.2_Missense_Mutation_p.C44Y	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	279	Helical; (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		ATTCACGGATGTATTGTGGCT	0.428													A	50494831	A	A	50494831	3	1	119	1	0	0	0	0	1	0	0	0	14526	1377	48	3	846	3	SLC27A2	15	50494831	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08		50494831	52036561	73	8226											
BLM	641	broad.mit.edu	37	chr15	91312761	91312761	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggctcttacggccacagctAatcccagggtacagaaggac	11	12	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr15:91312761A>T	uc002bpr.2	+	12	2597	c.2500A>T	c.(2500-2502)AAT>TAT	p.N834Y	BLM_uc010uqh.1_Missense_Mutation_p.N834Y|BLM_uc010uqi.1_Missense_Mutation_p.N459Y|BLM_uc010bnx.2_Missense_Mutation_p.N834Y|BLM_uc002bps.1_Missense_Mutation_p.N396Y	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	834	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GGCCACAGCTAATCCCAGGGT	0.478			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				T	91312761	T	T	91312761	3	4	119	1	0	0	0	0	1	0	0	0	1445	362	13	5	2542	5	BLM	15	91312761	Missense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08	40817930	91312761	11218631	74	8227											
CDH16	1014	broad.mit.edu	37	chr16	66950022	66950022	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatggcttgagagaaatgggGcacctggtcattctcatcct	12	9	2	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr16:66950022G>T	uc002eql.2	-	5	443	c.370C>A	c.(370-372)CCC>ACC	p.P124T	CDH16_uc010cdy.2_Missense_Mutation_p.P124T|CDH16_uc002eqm.2_Intron	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	124	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GAGAAATGGGGCACCTGGTCA	0.582													T	66950022	T	T	66950022	3	4	119	1	0	0	0	0	1	0	0	0	3101	1203	42	5	2175	5	CDH16	16	66950022	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08		66950022	23404731	75	8228											
PHLPP2	23035	broad.mit.edu	37	chr16	71724459	71724459	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcaaaatgtgcatctttccaGtttgacaatccttcactgag	7	10	2	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr16:71724459G>C	uc002fax.2	-	3	578	c.572C>G	c.(571-573)ACT>AGT	p.T191S	PHLPP2_uc010cgf.2_Missense_Mutation_p.T191S|PHLPP2_uc002fay.1_Missense_Mutation_p.T191S	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	191	PH.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						CATCTTTCCAGTTTGACAATC	0.408													C	71724459	C	C	71724459	3	2	119	1	0	0	0	0	1	0	0	0	11855	1029	36	5	3463	5	PHLPP2	16	71724459	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	4774437	71724459	18630294	76	8229											
MYH3	4621	broad.mit.edu	37	chr17	10533648	10533648	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttcttcccgcccttcagcGccagctgctcggcctcatct	8	19	4	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr17:10533648G>A	uc002gmq.1	-	36	5491	c.5414C>T	c.(5413-5415)GCG>GTG	p.A1805V		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1805	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						GCCCTTCAGCGCCAGCTGCTC	0.607													A	10533648	A	A	10533648	3	1	119	1	0	0	0	0	1	0	0	0	10036	1087	38	1	428	1	MYH3	17	10533648	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08		10533648	70661562	77	8230											
ANKRD13B	124930	broad.mit.edu	37	chr17	27939203	27939203	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gagcaggtggcccccatcatTgacctcatggccgtcagcaa	11	14	3	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr17:27939203T>A	uc002hei.2	+	11	1283	c.1170T>A	c.(1168-1170)ATT>ATA	p.I390I	ANKRD13B_uc002heh.2_Silent_p.I258I|ANKRD13B_uc002hej.2_RNA|ANKRD13B_uc002hek.2_5'Flank	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	390											0						CCCCCATCATTGACCTCATGG	0.597													A	27939203	A	A	27939203	2	1	119	1	0	0	0	0	0	0	0	1	642	1800	63	5		5	ANKRD13B	17	27939203	Silent	SNP	T	TCGA-12-3649-01A-01D-1495-08	17405555	27939203	53256007	78	8231											
MEP1B	4225	broad.mit.edu	37	chr18	29787380	29787380	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgaggatgtgatcggccaacGaatggatttcagtgactctg	13	7	2	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr18:29787380G>A	uc002kxj.3	+	8	760	c.713G>A	c.(712-714)CGA>CAA	p.R238Q		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	238	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						ATCGGCCAACGAATGGATTTC	0.388													A	29787380	A	A	29787380	3	1	119	1	0	0	0	0	1	0	0	0	9476	1058	37	2	743	2	MEP1B	18	29787380	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08		29787380	48289868	79	8232											
CBLN2	147381	broad.mit.edu	37	chr18	70209243	70209243	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgggctccgtgtcgttctgCgcccgcacggggcagcaggc	16	14	1	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr18:70209243C>T	uc002lku.2	-	2	388	c.153G>A	c.(151-153)GCG>GCA	p.A51A	CBLN2_uc002lkv.2_Silent_p.A51A	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	51						integral to membrane					0		Esophageal squamous(42;0.131)				TGTCGTTCTGCGCCCGCACGG	0.607													T	70209243	T	T	70209243	2	4	119	1	0	0	0	0	0	0	0	1	2705	755	27	1		1	CBLN2	18	70209243	Silent	SNP	C	TCGA-12-3649-01A-01D-1495-08	40421863	70209243	7868005	80	8233											
C19orf21	126353	broad.mit.edu	37	chr19	758162	758162	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagcccggccccagatgccCgtgcggccgacccagctcca	11	20	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr19:758162C>T	uc002lpo.2	+	2	1299	c.1216C>T	c.(1216-1218)CGT>TGT	p.R406C		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	406										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGATGCCCGTGCGGCCGA	0.682													T	758162	T	T	758162	3	4	119	1	0	0	0	0	1	0	0	0	1913	652	23	2	1218	2	C19orf21	19	758162	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08		758162	58370821	81	8234											
GADD45B	4616	broad.mit.edu	37	chr19	2477591	2477591	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tcccctacatctctcttcagGaacgctgaggcccttcccag	7	17	3	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr19:2477591G>C	uc002lwb.1	+	4	697	c.475G>C	c.(475-477)GAA>CAA	p.E159Q		NM_015675	NP_056490	O75293	GA45B_HUMAN	growth arrest and DNA-damage-inducible, beta	159					activation of MAPKKK activity|apoptosis|cell differentiation|multicellular organismal development|response to stress						0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCTCTTCAGGAACGCTGAGG	0.562													C	2477591	C	C	2477591	3	2	119	1	0	0	0	0	1	0	0	0	6182	1175	41	5	489	5	GADD45B	19	2477591	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	1719429	2477591	56651392	82	8235											
CPAMD8	27151	broad.mit.edu	37	chr19	17086956	17086956	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatttgctgaatacgtcacTgaaaccttggcgcaaatgca	8	10	2	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr19:17086956T>C	uc002nfb.2	-	16	1937	c.1905A>G	c.(1903-1905)TCA>TCG	p.S635S		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	588						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						AATACGTCACTGAAACCTTGG	0.393													C	17086956	C	C	17086956	2	2	119	1	0	0	0	0	0	0	0	1	3795	1567	55	4		4	CPAMD8	19	17086956	Silent	SNP	T	TCGA-12-3649-01A-01D-1495-08	14609365	17086956	42042027	83	8236											
B3GNT3	10331	broad.mit.edu	37	chr19	17918748	17918748	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagcagccaccggcgatcccCgaggccctggcctggcccac	13	19	0	0	rs79614823	byFrequency	TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr19:17918748C>T	uc002nhk.1	+	2	217	c.132C>T	c.(130-132)CCC>CCT	p.P44P	B3GNT3_uc002nhl.1_Silent_p.P44P|B3GNT3_uc010ebd.1_Silent_p.P44P|B3GNT3_uc010ebe.1_Silent_p.P44P	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	44	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						CGGCGATCCCCGAGGCCCTGG	0.687													T	17918748	T	T	17918748	2	4	119	1	0	0	0	0	0	0	0	1	1258	639	23	2		2	B3GNT3	19	17918748	Silent	SNP	C	TCGA-12-3649-01A-01D-1495-08	831792	17918748	41210235	84	8237											
ZNF493	284443	broad.mit.edu	37	chr19	21606457	21606457	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtggcaaagcctttagtatTttctcaacccctactaaaca	5	11	1	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr19:21606457T>C	uc002npx.2	+	2	892	c.612T>C	c.(610-612)ATT>ATC	p.I204I	ZNF493_uc002npw.2_Silent_p.I332I|ZNF493_uc002npy.2_Silent_p.I204I	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	204	C2H2-type 7; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCTTTAGTATTTTCTCAACCC	0.348													C	21606457	C	C	21606457	2	2	119	1	0	0	0	0	0	0	0	1	17941	1829	64	4		4	ZNF493	19	21606457	Silent	SNP	T	TCGA-12-3649-01A-01D-1495-08	3687709	21606457	37522526	85	8238											
LSR	51599	broad.mit.edu	37	chr19	35757850	35757850	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccttctcgacctggcccccCcagtggccgtgtggagcggg	14	17	1	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr19:35757850C>T	uc002nyl.2	+	8	1491	c.1268C>T	c.(1267-1269)CCC>CTC	p.P423L	LSR_uc002nym.2_Missense_Mutation_p.P404L|LSR_uc002nyn.2_Missense_Mutation_p.P355L|LSR_uc002nyo.2_Missense_Mutation_p.P403L|LSR_uc010xsr.1_Missense_Mutation_p.P315L|LSR_uc002nyp.2_Missense_Mutation_p.P365L|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	423	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCTGGCCCCCCCAGTGGCCGT	0.622													T	35757850	T	T	35757850	3	4	119	1	0	0	0	0	1	0	0	0	9064	623	22	3	1298	3	LSR	19	35757850	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	14151393	35757850	23371133	86	8239											
CEACAM18	729767	broad.mit.edu	37	chr19	51986389	51986389	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tattccttcctggatctcaaGtaccactggatccacaatgg	7	12	1	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr19:51986389G>A	uc002pwv.1	+	5	975	c.975G>A	c.(973-975)AAG>AAA	p.K325K		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	325	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGGATCTCAAGTACCACTGGA	0.512													A	51986389	A	A	51986389	2	1	119	1	0	0	0	0	0	0	0	1	3189	1020	36	3		3	CEACAM18	19	51986389	Silent	SNP	G	TCGA-12-3649-01A-01D-1495-08	16228539	51986389	7142594	87	8240											
ZNF845	91664	broad.mit.edu	37	chr19	53855879	53855879	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tcagtttcaaatcaaaccttCaaagacataggagaattcat	5	8	5	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr19:53855879C>G	uc010ydv.1	+	4	2068	c.1951C>G	c.(1951-1953)CAA>GAA	p.Q651E	ZNF845_uc010ydw.1_Missense_Mutation_p.Q651E	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	651	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATCAAACCTTCAAAGACATAG	0.398													G	53855879	G	G	53855879	3	3	119	1	0	0	0	0	1	0	0	0	18188	827	29	5	1961	5	ZNF845	19	53855879	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	1869490	53855879	5273104	88	8241											
ZSCAN5B	342933	broad.mit.edu	37	chr19	56704064	56704064	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgggtcttctgttatttcGtagcaggtcctccaggtctt	10	10	3	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr19:56704064G>A	uc010ygh.1	-	1	358	c.358C>T	c.(358-360)CGA>TGA	p.R120*		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	120	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CTGTTATTTCGTAGCAGGTCC	0.537													A	56704064	A	A	56704064	4	1	119	1	0	0	0	0	0	1	0	0	18236	1153	40	1	1145	1	ZSCAN5B	19	56704064	Nonsense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	2848185	56704064	2424919	89	8242											
ACTR5	79913	broad.mit.edu	37	chr20	37383758	37383758	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaggagctcaatgcccggCggcgggaggagaagctgcag	18	10	1	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr20:37383758C>T	uc002xjd.2	+	4	959	c.934C>T	c.(934-936)CGG>TGG	p.R312W		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog	312	Potential.				DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				CAATGCCCGGCGGCGGGAGGA	0.597													T	37383758	T	T	37383758	3	4	119	1	0	0	0	0	1	0	0	0	215	759	27	1	948	1	ACTR5	20	37383758	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08		37383758	25641762	90	8243											
SALL4	57167	broad.mit.edu	37	chr20	50400910	50400910	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ctgcactgatacccgactggGagccatccatcttggagaca	10	13	1	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr20:50400910G>C	uc002xwh.3	-	4	3157	c.3056C>G	c.(3055-3057)TCC>TGC	p.S1019C	SALL4_uc010gii.2_Missense_Mutation_p.S582C|SALL4_uc002xwi.3_Missense_Mutation_p.S242C	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	1019					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ACCCGACTGGGAGCCATCCAT	0.542													C	50400910	C	C	50400910	3	2	119	1	0	0	0	0	1	0	0	0	13813	1174	41	5	109	5	SALL4	20	50400910	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	13017152	50400910	12624610	91	8244											
PRIC285	85441	broad.mit.edu	37	chr20	62195800	62195800	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatcacctcctccgcctcctCgtaggacagctggcggtcag	11	16	2	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr20:62195800C>T	uc002yfm.2	-	9	5267	c.4375G>A	c.(4375-4377)GAG>AAG	p.E1459K	PRIC285_uc002yfl.1_Missense_Mutation_p.E890K	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1459					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TCCGCCTCCTCGTAGGACAGC	0.682													T	62195800	T	T	62195800	3	4	119	1	0	0	0	0	1	0	0	0	12485	893	31	2	3622	2	PRIC285	20	62195800	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	11794890	62195800	829720	92	8245											
PMM1	5372	broad.mit.edu	37	chr22	41974860	41974860	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actctgttttcagggcttccAcgaacttctcccggatcttc	7	14	4	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chr22:41974860A>G	uc003bal.2	-	6	562	c.500T>C	c.(499-501)GTG>GCG	p.V167A		NM_002676	NP_002667	Q92871	PMM1_HUMAN	phosphomannomutase 1	167					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			ovary(1)	1						CAGGGCTTCCACGAACTTCTC	0.468													G	41974860	G	G	41974860	3	3	119	1	0	0	0	0	1	0	0	0	12136	159	6	4	300	4	PMM1	22	41974860	Missense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08		41974860	9329706	93	8246											
DMD	1756	broad.mit.edu	37	chrX	31165414	31165414	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gctccagcagctgccttagcCtgtgtaactgtgactccagc	10	14	0	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chrX:31165414C>G	uc004dda.1	-	75	11019	c.10775G>C	c.(10774-10776)AGG>ACG	p.R3592T	DMD_uc004dcq.1_Missense_Mutation_p.R863T|DMD_uc004dcr.1_Missense_Mutation_p.R1012T|DMD_uc004dcs.1_Missense_Mutation_p.R1022T|DMD_uc004dct.1_Missense_Mutation_p.R1132T|DMD_uc004dcu.1_Missense_Mutation_p.R1132T|DMD_uc004dcv.1_Missense_Mutation_p.R1119T|DMD_uc004dcw.2_Missense_Mutation_p.R2248T|DMD_uc004dcx.2_Missense_Mutation_p.R2251T|DMD_uc004dcz.2_Missense_Mutation_p.R3469T|DMD_uc004dcy.1_Missense_Mutation_p.R3588T|DMD_uc004ddb.1_Missense_Mutation_p.R3584T|DMD_uc004dcm.1_Missense_Mutation_p.R524T|DMD_uc004dcn.1_Missense_Mutation_p.R511T|DMD_uc004dco.1_Missense_Mutation_p.R524T|DMD_uc004dcp.1_Missense_Mutation_p.R511T|DMD_uc011mkb.1_Missense_Mutation_p.R414T	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3592					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTGCCTTAGCCTGTGTAACTG	0.458													G	31165414	G	G	31165414	3	3	119	1	0	0	0	0	1	0	0	0	4580	681	24	5	388	5	DMD	23	31165414	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08		31165414	124105146	94	8247											
MAGEB16	139604	broad.mit.edu	37	chrX	35820765	35820765	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caaagatgatgagagccactTctctgagatcctcctgagag	10	10	1	5			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chrX:35820765T>A	uc010ngt.1	+	2	731	c.452T>A	c.(451-453)TTC>TAC	p.F151Y		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	151	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						GAGAGCCACTTCTCTGAGATC	0.448													A	35820765	A	A	35820765	3	1	119	1	0	0	0	0	1	0	0	0	9174	1783	62	5	454	5	MAGEB16	23	35820765	Missense_Mutation	SNP	T	TCGA-12-3649-01A-01D-1495-08	4655351	35820765	119449795	95	8248											
TGIF2LX	90316	broad.mit.edu	37	chrX	89177576	89177576	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccctgtggcccttgccaaaGggccagatgtcaagagagaa	12	12	1	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chrX:89177576G>A	uc004efe.2	+	2	541	c.492G>A	c.(490-492)AAG>AAA	p.K164K		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	164						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CCTTGCCAAAGGGCCAGATGT	0.592													A	89177576	A	A	89177576	2	1	119	1	0	0	0	0	0	0	0	1	15824	991	35	3		3	TGIF2LX	23	89177576	Silent	SNP	G	TCGA-12-3649-01A-01D-1495-08	53356811	89177576	66092984	96	8249											
DIAPH2	1730	broad.mit.edu	37	chrX	96212894	96212894	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acctccattgccaggtgtagGgccgcctccaccaccacccg	9	19	0	0			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chrX:96212894G>T	uc004efu.3	+	16	2078	c.1682G>T	c.(1681-1683)GGG>GTG	p.G561V	DIAPH2_uc004eft.3_Missense_Mutation_p.G561V	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	561	FH1.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						CCAGGTGTAGGGCCGCCTCCA	0.537													T	96212894	T	T	96212894	3	4	119	1	0	0	0	0	1	0	0	0	4519	1232	43	5	1744	5	DIAPH2	23	96212894	Missense_Mutation	SNP	G	TCGA-12-3649-01A-01D-1495-08	7035318	96212894	59057666	97	8250											
MAGEC2	51438	broad.mit.edu	37	chrX	141291061	141291061	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggcacagttgccctttatgAagatcacactcagaataata	7	9	2	3			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chrX:141291061A>T	uc004fbu.1	-	3	1061	c.713T>A	c.(712-714)TTC>TAC	p.F238Y		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	238	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GCCCTTTATGAAGATCACACT	0.512										HNSCC(46;0.14)			T	141291061	T	T	141291061	3	4	119	1	0	0	0	0	1	0	0	0	9181	246	9	5	412	5	MAGEC2	23	141291061	Missense_Mutation	SNP	A	TCGA-12-3649-01A-01D-1495-08	45078167	141291061	13979499	98	8251											
MAGEA12	4111	broad.mit.edu	37	chrX	151900207	151900207	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	acgattatcaggaggcctgtCttgggcacgatctgattgtc	12	9	3	1			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chrX:151900207C>A	uc010ntp.2	-	3	948	c.594G>T	c.(592-594)AAG>AAT	p.K198N	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.K198N	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	198	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGAGGCCTGTCTTGGGCACGA	0.577													A	151900207	A	A	151900207	3	1	119	1	0	0	0	0	1	0	0	0	9166	912	32	5	354	5	MAGEA12	23	151900207	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	10609146	151900207	3370353	99	8252											
SPRY3	10251	broad.mit.edu	37	chrX	155003952	155003952	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgagcaatctgcagggcaccCtagtgagcacctcttcatct	9	13	4	2			TCGA-12-3649-01A-01D-1495-08	TCGA-12-3649-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	2580567a-8f51-4cb7-9525-bba987c55e36	75bb80be-e071-475d-829e-b6a635281011	g.chrX:155003952C>A	uc004fnq.1	+	2	873	c.419C>A	c.(418-420)CCT>CAT	p.P140H	SPRY3_uc010nvl.1_Intron	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	140					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCAGGGCACCCTAGTGAGCAC	0.612													A	155003952	A	A	155003952	3	1	119	1	0	0	0	0	1	0	0	0	15106	681	24	5	421	5	SPRY3	23	155003952	Missense_Mutation	SNP	C	TCGA-12-3649-01A-01D-1495-08	3103745	155003952	266608	100	8253											
FOXJ3	22887	broad.mit.edu	37	chr1	42693556	42693556	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgataaagagcctttacccGttctacagatcgtgccctct	7	12	2	3			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr1:42693556G>A	uc001che.2	-	7	838	c.526C>T	c.(526-528)CGG>TGG	p.R176W	FOXJ3_uc001chf.2_Missense_Mutation_p.R176W|FOXJ3_uc001chg.2_Missense_Mutation_p.R176W|FOXJ3_uc001chh.1_Missense_Mutation_p.R176W	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	176					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCCTTTACCCGTTCTACAGAT	0.393													A	42693556	A	A	42693556	3	1	120	1	0	0	0	0	1	0	0	0	6013	1144	40	1	1378	1	FOXJ3	1	42693556	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08		42693556	206557065	1	8254											
NSUN4	387338	broad.mit.edu	37	chr1	46810560	46810560	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagtttggagatctttggCcatcaatccgtgtcagtctc	10	10	4	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr1:46810560C>T	uc001cpr.1	+	2	290	c.181C>T	c.(181-183)CCA>TCA	p.P61S	NSUN4_uc010omc.1_Missense_Mutation_p.P12S|NSUN4_uc009vyf.1_5'UTR|NSUN4_uc009vyg.1_Missense_Mutation_p.P12S|NSUN4_uc001cpt.1_RNA|NSUN4_uc001cps.1_RNA	NM_199044	NP_950245	Q96CB9	NSUN4_HUMAN	NOL1/NOP2/Sun domain family 4 protein	61							methyltransferase activity				0	Acute lymphoblastic leukemia(166;0.155)					AGATCTTTGGCCATCAATCCG	0.488													T	46810560	T	T	46810560	3	4	120	1	0	0	0	0	1	0	0	0	10680	739	26	3	187	3	NSUN4	1	46810560	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	4117004	46810560	202440061	2	8255											
COL11A1	1301	broad.mit.edu	37	chr1	103487313	103487313	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcctttctctccatatgcacCatggccatttatctgttgaa	5	12	2	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr1:103487313C>A	uc001dul.2	-	9	1576	c.1258G>T	c.(1258-1260)GGT>TGT	p.G420C	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.G432C|COL11A1_uc001dun.2_Missense_Mutation_p.G381C|COL11A1_uc009weh.2_Missense_Mutation_p.G304C	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	420	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCATATGCACCATGGCCATTT	0.303													A	103487313	A	A	103487313	3	1	120	1	0	0	0	0	1	0	0	0	3667	594	21	5	4398	5	COL11A1	1	103487313	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	56676753	103487313	145763308	3	8256											
HSPA6	3310	broad.mit.edu	37	chr1	161495457	161495457	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcccagattcatgacgtcGtcctggtggggggctccaca	14	12	1	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr1:161495457G>A	uc001gap.2	+	2	1669	c.1009G>A	c.(1009-1011)GTC>ATC	p.V337I	HSPA6_uc001gaq.2_Missense_Mutation_p.V337I	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	337					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TCATGACGTCGTCCTGGTGGG	0.597													A	161495457	A	A	161495457	3	1	120	1	0	0	0	0	1	0	0	0	7415	1145	40	1	1011	1	HSPA6	1	161495457	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	58008144	161495457	87755164	4	8257											
CFHR2	3080	broad.mit.edu	37	chr1	196927110	196927110	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tatatgctccaggttcatcaGttgagtaccagtgccagaac	9	10	2	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr1:196927110G>T	uc001gtq.1	+	4	597	c.520G>T	c.(520-522)GTT>TTT	p.V174F	CFHR2_uc001gtr.1_Missense_Mutation_p.V50F	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	174	Sushi 3.					extracellular region				skin(2)|ovary(1)	3						AGGTTCATCAGTTGAGTACCA	0.403													T	196927110	T	T	196927110	3	4	120	1	0	0	0	0	1	0	0	0	3285	1029	36	5	534	5	CFHR2	1	196927110	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	35431653	196927110	52323511	5	8258											
PLB1	151056	broad.mit.edu	37	chr2	28741363	28741363	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attctccattcccatgcaacCcaaataaattaggagtgaat	5	10	1	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr2:28741363C>A	uc002rmb.1	+	3	148	c.148C>A	c.(148-150)CCA>ACA	p.P50T	PLB1_uc010ezj.1_Missense_Mutation_p.P50T	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	50	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CCCATGCAACCCAAATAAATT	0.428													A	28741363	A	A	28741363	3	1	120	1	0	0	0	0	1	0	0	0	12024	623	22	5	158	5	PLB1	2	28741363	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08		28741363	214458010	6	8259											
STK32B	55351	broad.mit.edu	37	chr4	5461833	5461833	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgccctctaactgcagctcCtgaccaaggatcctgagagc	9	14	1	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr4:5461833C>T	uc003gih.1	+	9	851	c.787C>T	c.(787-789)CTG>TTG	p.L263L	STK32B_uc010ida.1_Silent_p.L216L	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	263	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						ACTGCAGCTCCTGACCAAGGA	0.552											OREG0016061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	5461833	T	T	5461833	2	4	120	1	0	0	0	0	0	0	0	1	15297	680	24	3		3	STK32B	4	5461833	Silent	SNP	C	TCGA-12-3650-01A-01D-1495-08		5461833	185692443	7	8260											
ADH1B	125	broad.mit.edu	37	chr4	100232699	100232699	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accataaacagcccccttccAggtgcgtccagtcagtagca	8	15	1	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr4:100232699A>C	uc003hus.3	-	7	1027	c.943T>G	c.(943-945)TGG>GGG	p.W315G	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Missense_Mutation_p.W275G|ADH1B_uc011ceh.1_Missense_Mutation_p.W160G|ADH1B_uc011cei.1_Missense_Mutation_p.W275G	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	315					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	GCCCCCTTCCAGGTGCGTCCA	0.383													C	100232699	C	C	100232699	3	2	120	1	0	0	0	0	1	0	0	0	308	188	7	5	196	5	ADH1B	4	100232699	Missense_Mutation	SNP	A	TCGA-12-3650-01A-01D-1495-08	94770866	100232699	90921577	8	8261											
TACR3	6870	broad.mit.edu	37	chr4	104640358	104640358	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaaagaagttctggaagcGgcagtagttggcgccaaagt	15	6	1	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr4:104640358G>A	uc003hxe.1	-	1	618	c.475C>T	c.(475-477)CGC>TGC	p.R159C		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	159	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TTCTGGAAGCGGCAGTAGTTG	0.542													A	104640358	A	A	104640358	3	1	120	1	0	0	0	0	1	0	0	0	15504	1116	39	2	942	2	TACR3	4	104640358	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	4407659	104640358	86513918	9	8262											
VEGFC	7424	broad.mit.edu	37	chr4	177650867	177650867	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctacactggacacagaccGtaactgctcctccagatctt	6	14	2	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr4:177650867G>A	uc003ius.1	-	2	611	c.181C>T	c.(181-183)CGG>TGG	p.R61W		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	61					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GACACAGACCGTAACTGCTCC	0.408													A	177650867	A	A	177650867	3	1	120	1	0	0	0	0	1	0	0	0	17149	1144	40	1	1105	1	VEGFC	4	177650867	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	73010509	177650867	13503409	10	8263											
PLEKHG4B	153478	broad.mit.edu	37	chr5	140705	140705	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagaagctccagaggggccCaggctgcagcctgccacacc	12	17	0	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr5:140705C>T	uc003jak.2	+	1	333	c.283C>T	c.(283-285)CAG>TAG	p.Q95*		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	95					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CAGAGGGGCCCAGGCTGCAGC	0.662													T	140705	T	T	140705	4	4	120	1	0	0	0	0	0	1	0	0	12072	595	21	3	285	3	PLEKHG4B	5	140705	Nonsense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08		140705	180774555	11	8264											
SLC6A19	340024	broad.mit.edu	37	chr5	1216997	1216997	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcagcggtgcaacgcctcCgaccccgcggcctacgcgca	12	19	0	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr5:1216997C>T	uc003jbw.3	+	8	1166	c.1110C>T	c.(1108-1110)TCC>TCT	p.S370S		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	370	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCAACGCCTCCGACCCCGCGG	0.627													T	1216997	T	T	1216997	2	4	120	1	0	0	0	0	0	0	0	1	14682	639	23	2		2	SLC6A19	5	1216997	Silent	SNP	C	TCGA-12-3650-01A-01D-1495-08	1076292	1216997	179698263	12	8265											
SLIT3	6586	broad.mit.edu	37	chr5	168310294	168310294	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcacatcggtgatgccgCggaacgccttcctcgggatc	11	14	2	1	rs138901310		TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr5:168310294C>T	uc003mab.2	-	5	881	c.461G>A	c.(460-462)CGC>CAC	p.R154H	SLIT3_uc010jjg.2_Missense_Mutation_p.R154H|SLIT3_uc010jji.2_Missense_Mutation_p.R154H	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	154	LRR 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGTGATGCCGCGGAACGCCTT	0.502													T	168310294	T	T	168310294	3	4	120	1	0	0	0	0	1	0	0	0	14741	768	27	1	4238	1	SLIT3	5	168310294	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	167093297	168310294	12604966	13	8266											
MUC21	394263	broad.mit.edu	37	chr6	30954349	30954349	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcacaccctccagtggggccAgcacagccaccaactctgac	9	18	1	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr6:30954349A>G	uc003nsh.2	+	2	648	c.397A>G	c.(397-399)AGC>GGC	p.S133G	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	133	Ser-rich.|7.|28 X 15 AA approximate tandem repeats.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CAGTGGGGCCAGCACAGCCAC	0.612													G	30954349	G	G	30954349	3	3	120	1	0	0	0	0	1	0	0	0	9977	188	7	4	403	4	MUC21	6	30954349	Missense_Mutation	SNP	A	TCGA-12-3650-01A-01D-1495-08		30954349	140160718	14	8267											
TFAP2D	83741	broad.mit.edu	37	chr6	50696983	50696983	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taaacttaccagcaggaagaCggaaagcagctaatgtcacc	9	10	1	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr6:50696983C>T	uc003paf.2	+	5	1353	c.841C>T	c.(841-843)CGG>TGG	p.R281W	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	281	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					AGCAGGAAGACGGAAAGCAGC	0.423													T	50696983	T	T	50696983	3	4	120	1	0	0	0	0	1	0	0	0	15787	527	19	1	859	1	TFAP2D	6	50696983	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	19742634	50696983	120418084	15	8268											
EPB41L2	2037	broad.mit.edu	37	chr6	131277174	131277174	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgagggtttttcttccttgCtcactgagggtttttcttcc	9	10	3	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr6:131277174C>G	uc003qch.2	-	2	634	c.452G>C	c.(451-453)AGC>ACC	p.S151T	EPB41L2_uc003qcg.1_Missense_Mutation_p.S151T|EPB41L2_uc011eby.1_Missense_Mutation_p.S151T|EPB41L2_uc003qci.2_Missense_Mutation_p.S151T|EPB41L2_uc010kfk.2_Missense_Mutation_p.S151T|EPB41L2_uc010kfl.1_Missense_Mutation_p.S151T	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	151					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TTCTTCCTTGCTCACTGAGGG	0.408													G	131277174	G	G	131277174	3	3	120	1	0	0	0	0	1	0	0	0	5153	797	28	5	2637	5	EPB41L2	6	131277174	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	80580191	131277174	39837893	16	8269											
C6orf118	168090	broad.mit.edu	37	chr6	165715366	165715366	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccctctctgacagcctccaCtggaaggaaatcctcctctg	7	17	2	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr6:165715366C>T	uc003qum.3	-	2	481	c.445G>A	c.(445-447)GTG>ATG	p.V149M	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	149											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		ACAGCCTCCACTGGAAGGAAA	0.627													T	165715366	T	T	165715366	3	4	120	1	0	0	0	0	1	0	0	0	2323	565	20	3	996	3	C6orf118	6	165715366	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	34438192	165715366	5399701	17	8270											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	120	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08		55221822	103916841	18	8271											
EGFR	1956	broad.mit.edu	37	chr7	55225428	55225428	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgagaacctagaaatcatacGcggcaggaccaagcaacagt	10	10	1	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr7:55225428G>T	uc003tqk.2	+	11	1526	c.1280G>T	c.(1279-1281)CGC>CTC	p.R427L	EGFR_uc003tqi.2_Missense_Mutation_p.R427L|EGFR_uc003tqj.2_Missense_Mutation_p.R427L|EGFR_uc010kzg.1_Missense_Mutation_p.R382L|EGFR_uc011kco.1_Missense_Mutation_p.R374L|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	427	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAAATCATACGCGGCAGGACC	0.368		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55225428	T	T	55225428	3	4	120	1	0	0	0	0	1	0	0	0	4967	1087	38	5	1333	5	EGFR	7	55225428	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	3606	55225428	103913235	19	8272											
CNPY4	245812	broad.mit.edu	37	chr7	99717380	99717380	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctttgtcatgggacctgtgCggttgggaatattgcttttc	13	7	1	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr7:99717380C>T	uc003uto.2	+	1	116	c.13C>T	c.(13-15)CGG>TGG	p.R5W	TAF6_uc003uti.2_5'Flank|TAF6_uc003utk.2_5'Flank|TAF6_uc011kji.1_5'UTR|TAF6_uc003utj.2_5'Flank|TAF6_uc003utl.2_5'Flank|TAF6_uc003utm.2_5'Flank|TAF6_uc003utn.1_5'Flank	NM_152755	NP_689968	Q8N129	CNPY4_HUMAN	canopy 4 homolog precursor	5						extracellular region					0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGGACCTGTGCGGTTGGGAAT	0.542													T	99717380	T	T	99717380	3	4	120	1	0	0	0	0	1	0	0	0	3630	759	27	1	15	1	CNPY4	7	99717380	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	44491952	99717380	59421283	20	8273											
SPDYE6	729597	broad.mit.edu	37	chr7	101989079	101989079	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agtggaagatgttttgtttgGagtcctcgtcgtcctcctcc	11	10	0	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr7:101989079G>T	uc011kkp.1	-	6	1215	c.794C>A	c.(793-795)TCC>TAC	p.S265Y	SPDYE6_uc003uzb.2_Missense_Mutation_p.S121Y	NM_001146210	NP_001139682	P0CI01	SPDE6_HUMAN	speedy homolog E6	265											0						GTTTTGTTTGGAGTCCTCGTC	0.557													T	101989079	T	T	101989079	3	4	120	1	0	0	0	0	1	0	0	0	15032	1174	41	5	422	5	SPDYE6	7	101989079	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	2271699	101989079	57149584	21	8274											
SPAM1	6677	broad.mit.edu	37	chr7	123594466	123594466	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tacactctatgtgcgcaatcGagttcgggaagccatcagag	11	10	2	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr7:123594466G>A	uc003vld.2	+	4	1244	c.842G>A	c.(841-843)CGA>CAA	p.R281Q	SPAM1_uc003vle.2_Missense_Mutation_p.R281Q|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.R281Q|SPAM1_uc010lku.2_Missense_Mutation_p.R281Q	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	281					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	GTGCGCAATCGAGTTCGGGAA	0.428													A	123594466	A	A	123594466	3	1	120	1	0	0	0	0	1	0	0	0	14986	1058	37	2	844	2	SPAM1	7	123594466	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	21605387	123594466	35544197	22	8275											
FLNC	2318	broad.mit.edu	37	chr7	128491526	128491526	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagggggtctgtcactggccGtggagggcccatccaaggca	16	12	2	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr7:128491526G>A	uc003vnz.3	+	35	5895	c.5686G>A	c.(5686-5688)GTG>ATG	p.V1896M	FLNC_uc003voa.3_Missense_Mutation_p.V1863M	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1896	Filamin 17.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GTCACTGGCCGTGGAGGGCCC	0.622													A	128491526	A	A	128491526	3	1	120	1	0	0	0	0	1	0	0	0	5935	1145	40	1	5824	1	FLNC	7	128491526	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	4897060	128491526	30647137	23	8276											
SLC13A4	26266	broad.mit.edu	37	chr7	135376342	135376342	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttcttcgctggaatgaggaaGaggaggaagccaaggaagac	15	6	1	3			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr7:135376342G>A	uc003vta.2	-	12	1961	c.1272C>T	c.(1270-1272)CTC>CTT	p.L424L	SLC13A4_uc003vtb.2_Silent_p.L425L|PL-5283_uc003vsz.3_RNA	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	424	Helical; (Potential).					integral to plasma membrane	sodium:sulfate symporter activity				0						GAATGAGGAAGAGGAGGAAGC	0.478													A	135376342	A	A	135376342	2	1	120	1	0	0	0	0	0	0	0	1	14394	929	33	3		3	SLC13A4	7	135376342	Silent	SNP	G	TCGA-12-3650-01A-01D-1495-08	6884816	135376342	23762321	24	8277											
CLU	1191	broad.mit.edu	37	chr8	27456003	27456003	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttttgcggtattcctgcagCgctttctccgccacggtctc	9	14	2	0	rs144959547	byFrequency	TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr8:27456003C>T	uc003xfw.1	-	7	1372	c.1314G>A	c.(1312-1314)GCG>GCA	p.A438A	CLU_uc010lux.1_Silent_p.A303A|CLU_uc003xfx.1_Silent_p.A438A|CLU_uc003xfy.1_Silent_p.A449A|CLU_uc003xfz.1_Silent_p.A490A	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2	438					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		ATTCCTGCAGCGCTTTCTCCG	0.542													T	27456003	T	T	27456003	2	4	120	1	0	0	0	0	0	0	0	1	3568	755	27	1		1	CLU	8	27456003	Silent	SNP	C	TCGA-12-3650-01A-01D-1495-08		27456003	118908019	25	8278											
ZBTB10	65986	broad.mit.edu	37	chr8	81431744	81431744	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggatgaatcaggagaagtttGtatgtctctagatgattaac	11	4	2	4			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr8:81431744G>T	uc003ybx.3	+	6	3195	c.2597G>T	c.(2596-2598)TGT>TTT	p.C866F	ZBTB10_uc003ybv.3_Missense_Mutation_p.C574F|ZBTB10_uc003ybw.3_Missense_Mutation_p.C842F|ZBTB10_uc010lzt.2_Missense_Mutation_p.C864F	NM_001105539	NP_001099009	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10 isoform	866					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)	1	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)			GGAGAAGTTTGTATGTCTCTA	0.408													T	81431744	T	T	81431744	3	4	120	1	0	0	0	0	1	0	0	0	17520	1377	48	5	2619	5	ZBTB10	8	81431744	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	53975741	81431744	64932278	26	8279											
TAF1L	138474	broad.mit.edu	37	chr9	32630679	32630679	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gctgtacaaatatccttctcAagttgagtcaaatgctcatc	6	10	3	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr9:32630679A>T	uc003zrg.1	-	1	4989	c.4899T>A	c.(4897-4899)CTT>CTA	p.L1633L	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1633					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TATCCTTCTCAAGTTGAGTCA	0.448													T	32630679	T	T	32630679	2	4	120	1	0	0	0	0	0	0	0	1	15520	117	5	5		5	TAF1L	9	32630679	Silent	SNP	A	TCGA-12-3650-01A-01D-1495-08		32630679	108582752	27	8280											
OR13C9	286362	broad.mit.edu	37	chr9	107379535	107379535	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtacattttgcattcacttGctaaagaaccttctgttcgg	7	9	2	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr9:107379535G>A	uc011lvr.1	-	1	951	c.951C>T	c.(949-951)AGC>AGT	p.S317S		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	317	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCATTCACTTGCTAAAGAACC	0.353													A	107379535	A	A	107379535	2	1	120	1	0	0	0	0	0	0	0	1	10939	1310	46	3		3	OR13C9	9	107379535	Silent	SNP	G	TCGA-12-3650-01A-01D-1495-08	74748856	107379535	33833896	28	8281											
SVEP1	79987	broad.mit.edu	37	chr9	113173765	113173765	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaatgagctatacaacgggGcatgtcttgaccttctgggg	13	8	2	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr9:113173765G>A	uc010mtz.2	-	37	6563	c.6226C>T	c.(6226-6228)CCC>TCC	p.P2076S	SVEP1_uc010mty.2_Missense_Mutation_p.P2S	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2076	Sushi 11.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ATACAACGGGGCATGTCTTGA	0.483													A	113173765	A	A	113173765	3	1	120	1	0	0	0	0	1	0	0	0	15417	1203	42	3	4537	3	SVEP1	9	113173765	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	5794230	113173765	28039666	29	8282											
ADAMTS13	11093	broad.mit.edu	37	chr9	136302931	136302931	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gcttcatcatgaagcgtggaGacagcttcctcgatgggacc	12	11	2	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr9:136302931G>A	uc004cdv.3	+	13	1942	c.1498G>A	c.(1498-1500)GAC>AAC	p.D500N	ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Missense_Mutation_p.D500N|ADAMTS13_uc004cdu.1_Missense_Mutation_p.D469N|ADAMTS13_uc004cdw.3_Missense_Mutation_p.D500N|ADAMTS13_uc004cdx.3_Missense_Mutation_p.D469N|ADAMTS13_uc004cdy.1_RNA|ADAMTS13_uc004cdz.3_Missense_Mutation_p.D170N|ADAMTS13_uc004cds.1_Intron|ADAMTS13_uc004cdr.1_RNA	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	500	Cell attachment site (Potential).				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GAAGCGTGGAGACAGCTTCCT	0.627													A	136302931	A	A	136302931	3	1	120	1	0	0	0	0	1	0	0	0	258	942	33	3	1548	3	ADAMTS13	9	136302931	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	23129166	136302931	4910500	30	8283											
YME1L1	10730	broad.mit.edu	37	chr10	27415646	27415646	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttttggaagtttacctccaaGaatagtaaatttttgtggat	8	4	0	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr10:27415646G>A	uc001iti.2	-	10	1281	c.1099C>T	c.(1099-1101)CTT>TTT	p.L367F	YME1L1_uc001itj.2_Missense_Mutation_p.L310F|YME1L1_uc010qdl.1_Missense_Mutation_p.L277F|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	367					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TTACCTCCAAGAATAGTAAAT	0.274													A	27415646	A	A	27415646	3	1	120	1	0	0	0	0	1	0	0	0	17484	942	33	3	1266	3	YME1L1	10	27415646	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08		27415646	108119101	31	8284											
DRGX	644168	broad.mit.edu	37	chr10	50599244	50599244	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acgtcgtccggttccggcgcTgttttctacgcagaaacccg	11	14	1	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr10:50599244T>G	uc010qgq.1	-	2	113	c.113A>C	c.(112-114)CAG>CCG	p.Q38P		NM_001080520	NP_001073989	A6NNA5	DRGX_HUMAN	dorsal root ganglia homeobox	38					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTTCCGGCGCTGTTTTCTACG	0.507													G	50599244	G	G	50599244	3	3	120	1	0	0	0	0	1	0	0	0	4763	1580	55	5	712	5	DRGX	10	50599244	Missense_Mutation	SNP	T	TCGA-12-3650-01A-01D-1495-08	23183598	50599244	84935503	32	8285											
MUC5B	727897	broad.mit.edu	37	chr11	1274084	1274084	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgcacggtggccaggtgcGtgggtgacaaccgtgtcgtc	16	11	0	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr11:1274084G>A	uc009ycr.1	+	54	16183	c.16057G>A	c.(16057-16059)GTG>ATG	p.V5353M	MUC5B_uc001ltb.2_Missense_Mutation_p.V5034M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5031					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGCCAGGTGCGTGGGTGACAA	0.632													A	1274084	A	A	1274084	3	1	120	1	0	0	0	0	1	0	0	0	9979	1145	40	1	15230	1	MUC5B	11	1274084	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08		1274084	133732432	33	8286											
MS4A1	931	broad.mit.edu	37	chr11	60231772	60231772	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttttacagtatattatttcCggatcactcctggcagcaac	6	10	1	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr11:60231772C>T	uc001npp.2	+	5	707	c.291C>T	c.(289-291)TCC>TCT	p.S97S	MS4A1_uc009ymy.1_3'UTR|MS4A1_uc001npq.2_Silent_p.S97S|MS4A1_uc009yna.2_Silent_p.S97S|MS4A1_uc009ymz.2_Silent_p.S97S|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	97	Helical; (Potential).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	ATATTATTTCCGGATCACTCC	0.438													T	60231772	T	T	60231772	2	4	120	1	0	0	0	0	0	0	0	1	9854	639	23	2		2	MS4A1	11	60231772	Silent	SNP	C	TCGA-12-3650-01A-01D-1495-08	58957688	60231772	74774744	34	8287											
PC	5091	broad.mit.edu	37	chr11	66637883	66637883	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgccgccgctggatggagcAgtctcgctcgtacaggtgca	15	12	1	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr11:66637883A>C	uc001ojn.1	-	7	842	c.793T>G	c.(793-795)TGC>GGC	p.C265G	PC_uc001ojo.1_Missense_Mutation_p.C265G|PC_uc001ojp.1_Missense_Mutation_p.C265G	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	265	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	TGGATGGAGCAGTCTCGCTCG	0.602													C	66637883	C	C	66637883	3	2	120	1	0	0	0	0	1	0	0	0	11497	188	7	5	2803	5	PC	11	66637883	Missense_Mutation	SNP	A	TCGA-12-3650-01A-01D-1495-08	6406111	66637883	68368633	35	8288											
IQSEC3	440073	broad.mit.edu	37	chr12	247990	247990	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcatgatggctttccgggaCgtcacggtgcagatcgccaa	12	12	2	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr12:247990C>T	uc001qhw.1	+	1	558	c.552C>T	c.(550-552)GAC>GAT	p.D184D	IQSEC3_uc001qhu.1_Silent_p.D184D|IQSEC3_uc001qht.1_Silent_p.D269D|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	487					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CTTTCCGGGACGTCACGGTGC	0.577													T	247990	T	T	247990	2	4	120	1	0	0	0	0	0	0	0	1	7819	535	19	1		1	IQSEC3	12	247990	Silent	SNP	C	TCGA-12-3650-01A-01D-1495-08		247990	133603905	36	8289											
APOBEC1	339	broad.mit.edu	37	chr12	7805403	7805403	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctctggggtcatagaagaCgtcaaactcccagggttcga	11	10	3	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr12:7805403C>T	uc001qtb.2	-	3	107	c.73G>A	c.(73-75)GTC>ATC	p.V25I	APOBEC1_uc001qtc.2_5'UTR|APOBEC1_uc010sgf.1_Missense_Mutation_p.V25I	NM_001644	NP_001635	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme	25					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding				0						TCATAGAAGACGTCAAACTCC	0.483													T	7805403	T	T	7805403	3	4	120	1	0	0	0	0	1	0	0	0	787	536	19	1	649	1	APOBEC1	12	7805403	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	7557413	7805403	126046492	37	8290											
PKP2	5318	broad.mit.edu	37	chr12	33031888	33031888	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggttttaggaacaggggaaCggcctccaacaaaatcattt	10	8	1	0	rs149542398	byFrequency	TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr12:33031888C>T	uc001rlj.3	-	2	417	c.302G>A	c.(301-303)CGT>CAT	p.R101H	PKP2_uc001rlk.3_Missense_Mutation_p.R101H|PKP2_uc010skj.1_Missense_Mutation_p.R101H	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	101					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AACAGGGGAACGGCCTCCAAC	0.378													T	33031888	T	T	33031888	3	4	120	1	0	0	0	0	1	0	0	0	11985	536	19	1	2395	1	PKP2	12	33031888	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	25226485	33031888	100820007	38	8291											
PDZRN4	29951	broad.mit.edu	37	chr12	41967460	41967460	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaagagcagcgccgtcgccGtgagttcatgatgcgaagca	13	11	1	3			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr12:41967460G>A	uc010skn.1	+	10	2350	c.2282G>A	c.(2281-2283)CGT>CAT	p.R761H	PDZRN4_uc001rmq.3_Missense_Mutation_p.R702H|PDZRN4_uc009zjz.2_Missense_Mutation_p.R700H|PDZRN4_uc001rmr.2_Missense_Mutation_p.R587H	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	960	Poly-Arg.						ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CGCCGTCGCCGTGAGTTCATG	0.527													A	41967460	A	A	41967460	3	1	120	1	0	0	0	0	1	0	0	0	11710	1145	40	1	2990	1	PDZRN4	12	41967460	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	8935572	41967460	91884435	39	8292											
ORAI1	84876	broad.mit.edu	37	chr12	122079482	122079482	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caacgagctggcggagtttgCccgcttacaggaccagctgg	14	12	0	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr12:122079482C>T	uc010szz.1	+	3	1032	c.839C>T	c.(838-840)GCC>GTC	p.A280V		NM_032790	NP_116179	Q96D31	CRCM1_HUMAN	calcium release-activated calcium channel	280	Cytoplasmic (Potential).				platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		GCGGAGTTTGCCCGCTTACAG	0.607													T	122079482	T	T	122079482	3	4	120	1	0	0	0	0	1	0	0	0	11257	739	26	3	851	3	ORAI1	12	122079482	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	80112022	122079482	11772413	40	8293											
FOXO1	2308	broad.mit.edu	37	chr13	41134348	41134348	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagggctcatgctggattggCcatatgtatatttttggtag	12	5	1	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr13:41134348C>A	uc001uxl.3	-	2	1665	c.1280G>T	c.(1279-1281)GGC>GTC	p.G427V	FOXO1_uc010acc.1_Missense_Mutation_p.G242V	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	427					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		GCTGGATTGGCCATATGTATA	0.488													A	41134348	A	A	41134348	3	1	120	1	0	0	0	0	1	0	0	0	6023	739	26	5	691	5	FOXO1	13	41134348	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08		41134348	74035530	41	8294											
CSPG4	1464	broad.mit.edu	37	chr15	75974722	75974722	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgggggccccgcaccacaCggtagagcaggagctggggg	19	12	0	1	rs143855050	byFrequency	TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr15:75974722C>T	uc002baw.2	-	8	4955	c.4862G>A	c.(4861-4863)CGT>CAT	p.R1621H		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1621	Extracellular (Potential).|Cysteine-containing.|Neurite growth inhibition (By similarity).|CSPG 11.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CCGCACCACACGGTAGAGCAG	0.662													T	75974722	T	T	75974722	3	4	120	1	0	0	0	0	1	0	0	0	3960	536	19	1	2118	1	CSPG4	15	75974722	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08		75974722	26556670	42	8295											
CHRNB4	1143	broad.mit.edu	37	chr15	78921864	78921864	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcacagtgtcatcttctcGccgcagtcggatggcaggta	12	11	3	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr15:78921864G>A	uc002bed.1	-	5	895	c.783C>T	c.(781-783)GGC>GGT	p.G261G	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Silent_p.G79G	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	261	Cytoplasmic (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						TCATCTTCTCGCCGCAGTCGG	0.567													A	78921864	A	A	78921864	2	1	120	1	0	0	0	0	0	0	0	1	3393	1074	38	1		1	CHRNB4	15	78921864	Silent	SNP	G	TCGA-12-3650-01A-01D-1495-08	2947142	78921864	23609528	43	8296											
CACNG3	10368	broad.mit.edu	37	chr16	24372858	24372858	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaaaaacatcagcagttaCgagccaaatcccactcggag	8	11	1	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr16:24372858C>T	uc002dmf.2	+	4	1822	c.622C>T	c.(622-624)CGA>TGA	p.R208*		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	208					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		TCAGCAGTTACGAGCCAAATC	0.488													T	24372858	T	T	24372858	4	4	120	1	0	0	0	0	0	1	0	0	2558	528	19	1	636	1	CACNG3	16	24372858	Nonsense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08		24372858	65981895	44	8297											
ABCC11	85320	broad.mit.edu	37	chr16	48210869	48210869	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccacgatgcccaccacttcGtggccgcggatggtcaggtt	12	15	1	0	rs143002804		TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr16:48210869G>A	uc002eff.1	-	24	3854	c.3504C>T	c.(3502-3504)CAC>CAT	p.H1168H	ABCC11_uc002efg.1_Silent_p.H1168H|ABCC11_uc002efh.1_Silent_p.H1168H|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	1168	ABC transporter 2.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CCACCACTTCGTGGCCGCGGA	0.562									Cerumen_Type				A	48210869	A	A	48210869	2	1	120	1	0	0	0	0	0	0	0	1	51	1136	40	1		1	ABCC11	16	48210869	Silent	SNP	G	TCGA-12-3650-01A-01D-1495-08	23838011	48210869	42143884	45	8298											
MAPK7	5598	broad.mit.edu	37	chr17	19284297	19284297	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggtgagatgctggcccggCgccagctcttcccaggcaaa	13	13	1	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr17:19284297C>T	uc002gvn.2	+	4	1161	c.775C>T	c.(775-777)CGC>TGC	p.R259C	B9D1_uc010cqm.1_5'Flank|B9D1_uc002gvl.3_5'Flank|MAPK7_uc002gvo.2_Missense_Mutation_p.R120C|MAPK7_uc002gvq.2_Missense_Mutation_p.R259C|MAPK7_uc002gvp.2_Missense_Mutation_p.R259C	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	259	Necessary for oligomerization (By similarity).|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					GCTGGCCCGGCGCCAGCTCTT	0.567													T	19284297	T	T	19284297	3	4	120	1	0	0	0	0	1	0	0	0	9282	768	27	1	785	1	MAPK7	17	19284297	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08		19284297	61910913	46	8299											
GAS2L2	246176	broad.mit.edu	37	chr17	34072485	34072485	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gctggcttaggggagccagtCggggctgccttccaggcttc	16	12	0	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr17:34072485C>T	uc002hjv.1	-	6	2059	c.2031G>A	c.(2029-2031)CCG>CCA	p.P677P		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	677					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGGAGCCAGTCGGGGCTGCCT	0.612													T	34072485	T	T	34072485	2	4	120	1	0	0	0	0	0	0	0	1	6247	871	31	2		2	GAS2L2	17	34072485	Silent	SNP	C	TCGA-12-3650-01A-01D-1495-08	14788188	34072485	47122725	47	8300											
LHX1	3975	broad.mit.edu	37	chr17	35297618	35297618	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ccaaatgcgcaggctgcgctCagggcatctcccctagcgac	11	16	2	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr17:35297618C>G	uc002hnh.1	+	2	1198	c.202C>G	c.(202-204)CAG>GAG	p.Q68E	LHX1_uc010cux.1_5'UTR	NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	68	LIM zinc-binding 2.				cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				AGGCTGCGCTCAGGGCATCTC	0.448													G	35297618	G	G	35297618	3	3	120	1	0	0	0	0	1	0	0	0	8770	827	29	5	208	5	LHX1	17	35297618	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	1225133	35297618	45897592	48	8301											
JUP	3728	broad.mit.edu	37	chr17	39919367	39919367	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtggcgcagagcgcagacGgcaggctccgtgatgtcgtc	17	11	0	3	rs77375949	by1000genomes	TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr17:39919367G>A	uc002hxq.2	-	8	1642	c.1365C>T	c.(1363-1365)GCC>GCT	p.A455A	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Silent_p.A455A|JUP_uc002hxs.2_Silent_p.A455A	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	455	ARM 6.				adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GAGCGCAGACGGCAGGCTCCG	0.607													A	39919367	A	A	39919367	2	1	120	1	0	0	0	0	0	0	0	1	7972	1103	39	2		2	JUP	17	39919367	Silent	SNP	G	TCGA-12-3650-01A-01D-1495-08	4621749	39919367	41275843	49	8302											
C17orf46	124783	broad.mit.edu	37	chr17	43333194	43333194	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgaaggtctgtggcgtggGcagccccatgttggagtgga	17	8	2	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr17:43333194G>A	uc002iis.1	-	4	451	c.355C>T	c.(355-357)CCC>TCC	p.P119S	LOC100133991_uc010dah.2_Intron|C17orf46_uc010wjk.1_Missense_Mutation_p.P98S	NM_152343	NP_689556	Q96LK8	CQ046_HUMAN	hypothetical protein LOC124783	119										large_intestine(1)|ovary(1)	2						TGTGGCGTGGGCAGCCCCATG	0.557													A	43333194	A	A	43333194	3	1	120	1	0	0	0	0	1	0	0	0	1857	1203	42	3	807	3	C17orf46	17	43333194	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	3413827	43333194	37862016	50	8303											
HOXB1	3211	broad.mit.edu	37	chr17	46607745	46607745	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcgaaggtccgggccgtgggGgtgttaggttctgaagggca	19	7	1	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr17:46607745G>T	uc002ink.1	-	1	528	c.522C>A	c.(520-522)ACC>ACA	p.T174T		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	174						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGGCCGTGGGGGTGTTAGGTT	0.592													T	46607745	T	T	46607745	2	4	120	1	0	0	0	0	0	0	0	1	7299	1219	43	5		5	HOXB1	17	46607745	Silent	SNP	G	TCGA-12-3650-01A-01D-1495-08	3274551	46607745	34587465	51	8304											
KIF19	124602	broad.mit.edu	37	chr17	72342551	72342551	+	Frame_Shift_Del	DEL	C	-	-													gcagcgtatgaaggagggggCccacatcaaccgctcactgc							TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr17:72342551delC	uc002jkm.3	+	8	950	c.812delC	c.(811-813)GCCfs	p.A271fs	KIF19_uc002jkj.2_Frame_Shift_Del_p.A271fs|KIF19_uc002jkk.2_Frame_Shift_Del_p.A229fs|KIF19_uc002jkl.2_Frame_Shift_Del_p.A229fs	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	271	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						AAGGAGGGGGCCCACATCAAC	0.597													-	72342551	-	-	72342551	7	5	120	1	0	1	0	1	0	0	0	0	8282	739	26	0	842	0	KIF19	17	72342551	Frame_Shift_Del	DEL	C	TCGA-12-3650-01A-01D-1495-08	25734806	72342551	8852659	52	8305											
CD300C	10871	broad.mit.edu	37	chr17	72539125	72539125	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggaggctgtggtcgtcccGgctgtgggtgaaacacaggt	17	9	0	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr17:72539125G>A	uc002jky.1	-	3	763	c.402C>T	c.(400-402)GCC>GCT	p.A134A		NM_006678	NP_006669	Q08708	CLM6_HUMAN	CD300C antigen precursor	134	Pro-rich.|Extracellular (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity				0						TGGTCGTCCCGGCTGTGGGTG	0.577													A	72539125	A	A	72539125	2	1	120	1	0	0	0	0	0	0	0	1	2997	1130	39	2		2	CD300C	17	72539125	Silent	SNP	G	TCGA-12-3650-01A-01D-1495-08	196574	72539125	8656085	53	8306											
C18orf21	83608	broad.mit.edu	37	chr18	33554930	33554930	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctggataactctcgagtgCgtctcaaacccaaagccagg	9	12	3	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr18:33554930C>T	uc002kzc.2	+	3	276	c.172C>T	c.(172-174)CGT>TGT	p.R58C	C18orf21_uc002kzd.2_5'UTR	NM_031446	NP_113634	Q32NC0	CR021_HUMAN	chromosome 18 open reading frame 21	58											0						CTCTCGAGTGCGTCTCAAACC	0.373													T	33554930	T	T	33554930	3	4	120	1	0	0	0	0	1	0	0	0	1897	768	27	1	182	1	C18orf21	18	33554930	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08		33554930	44522318	54	8307											
MUC16	94025	broad.mit.edu	37	chr19	9062926	9062926	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtggaagtctctggtgacaCtgtgagctgagcaaagcctg	14	8	1	3			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr19:9062926C>T	uc002mkp.2	-	3	24724	c.24520G>A	c.(24520-24522)GTG>ATG	p.V8174M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8176	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTGGTGACACTGTGAGCTGA	0.502													T	9062926	T	T	9062926	3	4	120	1	0	0	0	0	1	0	0	0	9973	565	20	3	19331	3	MUC16	19	9062926	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08		9062926	50066057	55	8308											
TMEM38A	79041	broad.mit.edu	37	chr19	16790904	16790904	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctccttggggagccactgatCgattacttcagcaacaactc	8	13	1	1	rs144587502		TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr19:16790904C>T	uc002nes.2	+	2	325	c.234C>T	c.(232-234)ATC>ATT	p.I78I		NM_024074	NP_076979	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	78	Cytoplasmic (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			central_nervous_system(2)|ovary(1)	3						AGCCACTGATCGATTACTTCA	0.602													T	16790904	T	T	16790904	2	4	120	1	0	0	0	0	0	0	0	1	16156	874	31	2		2	TMEM38A	19	16790904	Silent	SNP	C	TCGA-12-3650-01A-01D-1495-08	7727978	16790904	42338079	56	8309											
CCNE1	898	broad.mit.edu	37	chr19	30313489	30313489	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcacacaacatacagacccaCagagacagcttggatttgct	8	12	0	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr19:30313489C>G	uc002nsn.2	+	11	1272	c.1089C>G	c.(1087-1089)CAC>CAG	p.H363Q	CCNE1_uc002nso.2_Missense_Mutation_p.H348Q|CCNE1_uc002nsp.2_Missense_Mutation_p.H110Q	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	363					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			TACAGACCCACAGAGACAGCT	0.428													G	30313489	G	G	30313489	3	3	120	1	0	0	0	0	1	0	0	0	2920	477	17	5	1127	5	CCNE1	19	30313489	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	13522585	30313489	28815494	57	8310											
ZNF569	148266	broad.mit.edu	37	chr19	37904887	37904887	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tttaataagtttttccttgtGactgaaggcttttctacagt	7	6	1	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr19:37904887G>C	uc002ogi.2	-	6	1231	c.673C>G	c.(673-675)CAC>GAC	p.H225D	ZNF569_uc002ogh.2_Missense_Mutation_p.H66D|ZNF569_uc002ogj.2_Missense_Mutation_p.H249D	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	225	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTTCCTTGTGACTGAAGGCT	0.348													C	37904887	C	C	37904887	3	2	120	1	0	0	0	0	1	0	0	0	17997	1290	45	5	1391	5	ZNF569	19	37904887	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	7591398	37904887	21224096	58	8311											
EML2	24139	broad.mit.edu	37	chr19	46116829	46116829	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcaggggtagctaaacagGtgaactttgccaaagtcatc	11	9	1	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr19:46116829G>A	uc002pcn.2	-	18	1829	c.1794C>T	c.(1792-1794)CAC>CAT	p.H598H	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Silent_p.H482H|EML2_uc010xxl.1_Silent_p.H745H|EML2_uc010xxm.1_Silent_p.H799H	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	598	WD 10.				sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		AGCTAAACAGGTGAACTTTGC	0.572													A	46116829	A	A	46116829	2	1	120	1	0	0	0	0	0	0	0	1	5097	1252	44	3		3	EML2	19	46116829	Silent	SNP	G	TCGA-12-3650-01A-01D-1495-08	8211942	46116829	13012154	59	8312											
HCK	3055	broad.mit.edu	37	chr20	30681787	30681787	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgactttggcctggcccgggTcattgaggacaacgagtaca	13	10	1	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr20:30681787T>C	uc002wxh.2	+	11	1385	c.1214T>C	c.(1213-1215)GTC>GCC	p.V405A	HCK_uc010gdy.2_Missense_Mutation_p.V384A|HCK_uc002wxi.2_Missense_Mutation_p.V383A	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	405	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.P405S(1)		lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTGGCCCGGGTCATTGAGGAC	0.552													C	30681787	C	C	30681787	3	2	120	1	0	0	0	0	1	0	0	0	6994	1667	58	4	1262	4	HCK	20	30681787	Missense_Mutation	SNP	T	TCGA-12-3650-01A-01D-1495-08		30681787	32343733	60	8313											
C20orf132	140699	broad.mit.edu	37	chr20	35752057	35752057	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcctgttctgtgtacaggCcacttgggatgtcgacatca	10	11	2	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr20:35752057C>T	uc010zvu.1	-	17	2052	c.1961G>A	c.(1960-1962)GGC>GAC	p.G654D	C20orf132_uc002xgk.2_Missense_Mutation_p.G276D	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	55											0		Myeloproliferative disorder(115;0.00878)				TGTGTACAGGCCACTTGGGAT	0.408													T	35752057	T	T	35752057	3	4	120	1	0	0	0	0	1	0	0	0	2086	739	26	3	1237	3	C20orf132	20	35752057	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	5070270	35752057	27273463	61	8314											
HNF4A	3172	broad.mit.edu	37	chr20	43042366	43042366	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agcgggaccggatcagcactCgaaggtcaagctatgaggac	14	10	2	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chr20:43042366C>T	uc002xma.2	+	4	507	c.418C>T	c.(418-420)CGA>TGA	p.R140*	HNF4A_uc002xlt.2_Nonsense_Mutation_p.R118*|HNF4A_uc002xlu.2_Nonsense_Mutation_p.R118*|HNF4A_uc002xlv.2_Nonsense_Mutation_p.R118*|HNF4A_uc002xly.2_Nonsense_Mutation_p.R140*|HNF4A_uc002xlz.2_Nonsense_Mutation_p.R140*|HNF4A_uc010ggq.2_Nonsense_Mutation_p.R133*	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	140					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GATCAGCACTCGAAGGTCAAG	0.632													T	43042366	T	T	43042366	4	4	120	1	0	0	0	0	0	1	0	0	7253	876	31	2	485	2	HNF4A	20	43042366	Nonsense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	7290309	43042366	19983154	62	8315											
ASMT	438	broad.mit.edu	37	chrX	1746635	1746635	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggagacgtttggcgttccCgctgaagagctttttacggc	13	10	0	3			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chrX:1746635C>T	uc004cqd.2	+	5	559	c.414C>T	c.(412-414)CCC>CCT	p.P138P	ASMT_uc010ncy.2_Silent_p.P138P|ASMT_uc004cqe.2_Silent_p.P138P	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	138					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTGGCGTTCCCGCTGAAGAGC	0.353													T	1746635	T	T	1746635	2	4	120	1	0	0	0	0	0	0	0	1	1045	639	23	2		2	ASMT	23	1746635	Silent	SNP	C	TCGA-12-3650-01A-01D-1495-08		1746635	153523925	63	8316											
FIGF	2277	broad.mit.edu	37	chrX	15381369	15381369	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtcctcagagtgagtaattcGaagtagttcctccaaactag	9	9	1	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chrX:15381369G>A	uc004cwt.1	-	2	672	c.163C>T	c.(163-165)CGA>TGA	p.R55*		NM_004469	NP_004460	O43915	VEGFD_HUMAN	vascular endothelial growth factor D	55					angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					TGAGTAATTCGAAGTAGTTCC	0.453													A	15381369	A	A	15381369	4	1	120	1	0	0	0	0	0	1	0	0	5889	1066	37	2	925	2	FIGF	23	15381369	Nonsense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	13634734	15381369	139889191	64	8317											
KIAA1210	57481	broad.mit.edu	37	chrX	118221675	118221675	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caacagccattttctctagtCgtgaggtcatttcctgaact	7	11	2	2			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chrX:118221675C>T	uc004era.3	-	11	3518	c.3518G>A	c.(3517-3519)CGA>CAA	p.R1173Q		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1173										ovary(4)|skin(1)	5						TTTCTCTAGTCGTGAGGTCAT	0.468													T	118221675	T	T	118221675	3	4	120	1	0	0	0	0	1	0	0	0	8214	884	31	2	1627	2	KIAA1210	23	118221675	Missense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	102840306	118221675	37048885	65	8318											
FLNA	2316	broad.mit.edu	37	chrX	153588591	153588591	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatctcaatggtcagctccGcgctgcccgcgctcgagcag	12	15	2	1			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chrX:153588591G>A	uc004fkk.2	-	22	3821	c.3572C>T	c.(3571-3573)GCG>GTG	p.A1191V	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Missense_Mutation_p.A1191V	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1191	Filamin 10.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGTCAGCTCCGCGCTGCCCGC	0.642											OREG0003593	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	A	153588591	A	A	153588591	3	1	120	1	0	0	0	0	1	0	0	0	5933	1087	38	1	4479	1	FLNA	23	153588591	Missense_Mutation	SNP	G	TCGA-12-3650-01A-01D-1495-08	35366916	153588591	1681969	66	8319											
RAB39B	116442	broad.mit.edu	37	chrX	154490213	154490213	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctccccccttttaaccagctCatatatgtctcttgtcaggt	5	14	3	0			TCGA-12-3650-01A-01D-1495-08	TCGA-12-3650-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	8b1d52e2-489b-4972-9bef-1690ccd2bac9	53b6dbd6-219e-44c1-bc92-fcb93616394a	g.chrX:154490213C>A	uc004fne.2	-	2	796	c.517G>T	c.(517-519)GAG>TAG	p.E173*		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	173					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTAACCAGCTCATATATGTCT	0.473													A	154490213	A	A	154490213	4	1	120	1	0	0	0	0	0	1	0	0	12930	835	29	5	128	5	RAB39B	23	154490213	Nonsense_Mutation	SNP	C	TCGA-12-3650-01A-01D-1495-08	901622	154490213	780347	67	8320											
ARHGEF16	27237	broad.mit.edu	37	chr1	3394457	3394457	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtccctcccactgatctctGcctcccggtggctgctgaag	10	16	1	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr1:3394457G>A	uc001akg.3	+	11	1740	c.1492G>A	c.(1492-1494)GCC>ACC	p.A498T	ARHGEF16_uc001aki.2_Missense_Mutation_p.A210T|ARHGEF16_uc001akj.2_Missense_Mutation_p.A210T|ARHGEF16_uc010nzh.1_Missense_Mutation_p.A202T	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	498					activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		ACTGATCTCTGCCTCCCGGTG	0.622													A	3394457	A	A	3394457	3	1	121	1	0	0	0	0	1	0	0	0	899	1319	46	3	1530	3	ARHGEF16	1	3394457	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		3394457	245856164	1	8321											
ADCY10	55811	broad.mit.edu	37	chr1	167814945	167814945	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcatcttcttctaaaaagcGggcacatttcaagtgcatgg	10	9	4	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr1:167814945G>A	uc001ger.2	-	21	3161	c.2863C>T	c.(2863-2865)CGC>TGC	p.R955C	ADCY10_uc009wvk.2_Missense_Mutation_p.R863C|ADCY10_uc010plj.1_Missense_Mutation_p.R802C|ADCY10_uc009wvl.2_Missense_Mutation_p.R954C	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	955					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TCTAAAAAGCGGGCACATTTC	0.488													A	167814945	A	A	167814945	3	1	121	1	0	0	0	0	1	0	0	0	293	1116	39	2	2021	2	ADCY10	1	167814945	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	164420488	167814945	81435676	2	8322											
KIAA1614	57710	broad.mit.edu	37	chr1	180904433	180904433	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcccgcgaagccgagttccGtcacctggagcggctgcagc	14	16	1	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr1:180904433G>A	uc001gok.2	+	5	1455	c.1388G>A	c.(1387-1389)CGT>CAT	p.R463H	KIAA1614_uc001gol.1_Missense_Mutation_p.R84H|KIAA1614_uc001gom.1_Intron	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	463										ovary(3)|skin(1)	4						GCCGAGTTCCGTCACCTGGAG	0.731													A	180904433	A	A	180904433	3	1	121	1	0	0	0	0	1	0	0	0	8248	1145	40	1	1406	1	KIAA1614	1	180904433	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	13089488	180904433	68346188	3	8323											
GLUL	2752	broad.mit.edu	37	chr1	182356407	182356407	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgtaaagtactagagccatCgaaattccactcaggcaact	7	11	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr1:182356407C>T	uc001gpa.1	-	3	399	c.187G>A	c.(187-189)GAT>AAT	p.D63N	GLUL_uc010pnt.1_5'Flank|GLUL_uc001gpb.1_Missense_Mutation_p.D63N|GLUL_uc001gpc.1_Missense_Mutation_p.D63N|GLUL_uc001gpd.1_Missense_Mutation_p.D63N	NM_001033056	NP_001028228	P15104	GLNA_HUMAN	glutamine synthetase	63					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding				0					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	CTAGAGCCATCGAAATTCCAC	0.473													T	182356407	T	T	182356407	3	4	121	1	0	0	0	0	1	0	0	0	6478	884	31	2	954	2	GLUL	1	182356407	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	1451974	182356407	66894214	4	8324											
RAB3GAP2	25782	broad.mit.edu	37	chr1	220359030	220359030	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccattaaagtctgagtgatGtttctaaggcaagaaaatgg	10	5	2	3			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr1:220359030G>A	uc010puk.1	-	18	1997	c.1833C>T	c.(1831-1833)AAC>AAT	p.N611N	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Silent_p.N191N	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	611					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		TCTGAGTGATGTTTCTAAGGC	0.333													A	220359030	A	A	220359030	2	1	121	1	0	0	0	0	0	0	0	1	12936	1368	48	3		3	RAB3GAP2	1	220359030	Silent	SNP	G	TCGA-12-3652-01A-01D-1495-08	38002623	220359030	28891591	5	8325											
HLX	3142	broad.mit.edu	37	chr1	221057616	221057616	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaaggacaaggacaaggAggctggcgagaagccatcag	14	9	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr1:221057616A>G	uc001hmv.3	+	4	1494	c.1037A>G	c.(1036-1038)GAG>GGG	p.E346G		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	346					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		AAGGACAAGGAGGCTGGCGAG	0.667													G	221057616	G	G	221057616	3	3	121	1	0	0	0	0	1	0	0	0	7216	304	11	4	1051	4	HLX	1	221057616	Missense_Mutation	SNP	A	TCGA-12-3652-01A-01D-1495-08	698586	221057616	28193005	6	8326											
HHIPL2	79802	broad.mit.edu	37	chr1	222705452	222705452	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttcctgcaaagccataagtcGactagacaaaaaataaaccc	5	11	0	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr1:222705452G>A	uc001hnh.1	-	6	1637	c.1579C>T	c.(1579-1581)CGA>TGA	p.R527*		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	527					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GCCATAAGTCGACTAGACAAA	0.438													A	222705452	A	A	222705452	4	1	121	1	0	0	0	0	0	1	0	0	7094	1072	37	2	611	2	HHIPL2	1	222705452	Nonsense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	1647836	222705452	26545169	7	8327											
RYR2	6262	broad.mit.edu	37	chr1	237787140	237787151	+	In_Frame_Del	DEL	GATTTCCATGAA	-	-													aaattcgtgaccaactattgGatttccatgaagatttgatg							TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr1:237787140_237787151delGATTTCCATGAA	uc001hyl.1	+	39	6112_6123	c.5992_6003delGATTTCCATGAA	c.(5992-6003)GATTTCCATGAAdel	p.DFHE1998del		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1998_2001	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCAACTATTGGATTTCCATGAAGATTTGATGA	0.307													-	237787151	-	-	237787140	7	5	121	1	0	1	0	1	0	0	0	0	13769	1174	41	0	6146	0	RYR2	1	237787140	In_Frame_Del	DEL	GATTTCCATGAA	TCGA-12-3652-01A-01D-1495-08	15081688	237787140	11463481	8	8328											
RYR2	6262	broad.mit.edu	37	chr1	237947552	237947552	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgacgtggtcaacgaaggCggagagaaagagaagatgga	16	4	1	4			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr1:237947552C>T	uc001hyl.1	+	90	12660	c.12540C>T	c.(12538-12540)GGC>GGT	p.G4180G	RYR2_uc010pya.1_Silent_p.G595G	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4180					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCAACGAAGGCGGAGAGAAAG	0.502													T	237947552	T	T	237947552	2	4	121	1	0	0	0	0	0	0	0	1	13769	755	27	1		1	RYR2	1	237947552	Silent	SNP	C	TCGA-12-3652-01A-01D-1495-08	160412	237947552	11303069	9	8329											
ALMS1	7840	broad.mit.edu	37	chr2	73677648	73677648	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgataccaattttaccctctActttctactcacacacagag	3	13	3	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr2:73677648A>G	uc002sje.1	+	10	4108	c.3997A>G	c.(3997-3999)ACT>GCT	p.T1333A	ALMS1_uc002sjf.1_Missense_Mutation_p.T1289A|ALMS1_uc002sjg.2_Missense_Mutation_p.T719A|ALMS1_uc002sjh.1_Missense_Mutation_p.T719A	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1331	17.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TTTACCCTCTACTTTCTACTC	0.453													G	73677648	G	G	73677648	3	3	121	1	0	0	0	0	1	0	0	0	535	391	14	4	4021	4	ALMS1	2	73677648	Missense_Mutation	SNP	A	TCGA-12-3652-01A-01D-1495-08		73677648	169521725	10	8330											
INPP1	3628	broad.mit.edu	37	chr2	191236128	191236128	+	Nonstop_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cctgcagagacgcatacctaGaggaactctaaccccggtgt	10	13	1	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr2:191236128G>C	uc002ury.3	+	7	1900	c.1200G>C	c.(1198-1200)TAG>TAC	p.*400Y	INPP1_uc010fsb.2_Nonstop_Mutation_p.*400Y|INPP1_uc002urx.3_Nonstop_Mutation_p.*400Y	NM_001128928	NP_001122400	P49441	INPP_HUMAN	inositol polyphosphate-1-phosphatase	400					signal transduction		inositol-1,4-bisphosphate 1-phosphatase activity|metal ion binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.000286)|Epithelial(96;0.0186)|all cancers(119;0.057)		Lithium(DB01356)	CGCATACCTAGAGGAACTCTA	0.493													C	191236128	C	C	191236128	4	2	121	1	0	0	0	0	0	0	0	0	7751	937	33	5	1218	5	INPP1	2	191236128	Nonstop_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	117558480	191236128	51963245	11	8331											
CAV3	859	broad.mit.edu	37	chr3	8787341	8787341	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttgtccacgctgctgggcGtcccactggccctgctctgg	13	15	1	0	rs112626848		TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr3:8787341G>A	uc003bra.2	+	2	311	c.244G>A	c.(244-246)GTC>ATC	p.V82I	C3orf32_uc003bqz.2_5'Flank|CAV3_uc003brb.2_Missense_Mutation_p.V82I	NM_001234	NP_001225	P56539	CAV3_HUMAN	caveolin 3	82	Cytoplasmic (Potential).|Required for interaction with DAG1.				cell growth|elevation of cytosolic calcium ion concentration|muscle organ development|negative regulation of cardiac muscle hypertrophy|negative regulation of cell size|negative regulation of MAP kinase activity|negative regulation of sarcomere organization|positive regulation of microtubule polymerization|regulation of skeletal muscle contraction|regulation of ventricular cardiomyocyte membrane repolarization|T-tubule organization	caveola|dystrophin-associated glycoprotein complex|Golgi membrane|neuromuscular junction|T-tubule	protein C-terminus binding|protein complex binding|protein complex scaffold|sodium channel regulator activity			lung(1)|breast(1)	2						GCTGCTGGGCGTCCCACTGGC	0.587													A	8787341	A	A	8787341	3	1	121	1	0	0	0	0	1	0	0	0	2695	1145	40	1	250	1	CAV3	3	8787341	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		8787341	189235089	12	8332											
RPL32	6161	broad.mit.edu	37	chr3	12880946	12880946	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttgtttttttgttgcttccAtaaccaatgttgggcatcaa	7	7	1	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr3:12880946A>G	uc003bxl.2	-	2	393	c.180T>C	c.(178-180)TAT>TAC	p.Y60Y	RPL32_uc003bxm.2_Silent_p.Y60Y|RPL32_uc003bxn.2_Silent_p.Y60Y	NM_001007074	NP_001007075	P62910	RL32_HUMAN	ribosomal protein L32	60					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome			ovary(1)	1						TGTTGCTTCCATAACCAATGT	0.483													G	12880946	G	G	12880946	2	3	121	1	0	0	0	0	0	0	0	1	13582	224	8	4		4	RPL32	3	12880946	Silent	SNP	A	TCGA-12-3652-01A-01D-1495-08	4093605	12880946	185141484	13	8333											
IQSEC1	9922	broad.mit.edu	37	chr3	12977752	12977752	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgcgccgcatccagggccGgtgcctcctcagtgtgcagg	14	17	1	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr3:12977752G>A	uc003bxt.2	-	3	815	c.806C>T	c.(805-807)CCG>CTG	p.P269L	IQSEC1_uc003bxu.3_Missense_Mutation_p.P147L|IQSEC1_uc011auw.1_Missense_Mutation_p.P255L	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	269					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						ATCCAGGGCCGGTGCCTCCTC	0.642													A	12977752	A	A	12977752	3	1	121	1	0	0	0	0	1	0	0	0	7817	1116	39	2	2678	2	IQSEC1	3	12977752	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	96806	12977752	185044678	14	8334											
ZNF385D	79750	broad.mit.edu	37	chr3	21606168	21606168	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttattacagctttctgaatCgggtccatctgtaatgagaa	8	7	2	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr3:21606168C>T	uc003cce.2	-	3	582	c.174G>A	c.(172-174)CCG>CCA	p.P58P	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	58						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						CTTTCTGAATCGGGTCCATCT	0.358													T	21606168	T	T	21606168	2	4	121	1	0	0	0	0	0	0	0	1	17875	871	31	2		2	ZNF385D	3	21606168	Silent	SNP	C	TCGA-12-3652-01A-01D-1495-08	8628416	21606168	176416262	15	8335											
PRR23A	729627	broad.mit.edu	37	chr3	138724917	138724917	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacacgcagggcacagcccGcggccaggaccactatggag	14	15	0	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr3:138724917G>A	uc011bms.1	-	1	194	c.194C>T	c.(193-195)GCG>GTG	p.A65V		NM_001134659	NP_001128131	A6NEV1	PR23A_HUMAN	proline rich 23A	65											0						GGCACAGCCCGCGGCCAGGAC	0.721													A	138724917	A	A	138724917	3	1	121	1	0	0	0	0	1	0	0	0	12594	1087	38	1	610	1	PRR23A	3	138724917	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	117118749	138724917	59297513	16	8336											
MUC4	4585	broad.mit.edu	37	chr3	195515160	195515160	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaggtggcgtgacctgtggaTgctgaggaagtgtcagtgac	18	6	1	3			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr3:195515160T>C	uc011bto.1	-	2	3751	c.3291A>G	c.(3289-3291)GCA>GCG	p.A1097A	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACCTGTGGATGCTGAGGAAG	0.572													C	195515160	C	C	195515160	2	2	121	1	0	0	0	0	0	0	0	1	9978	1451	51	4		4	MUC4	3	195515160	Silent	SNP	T	TCGA-12-3652-01A-01D-1495-08	56790243	195515160	2507270	17	8337											
MAN2B2	23324	broad.mit.edu	37	chr4	6578364	6578364	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggtggaagagctggcccgCggccagcagcgccggttcat	17	12	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr4:6578364C>T	uc003gjf.1	+	2	234	c.198C>T	c.(196-198)CGC>CGT	p.R66R	MAN2B2_uc003gje.1_Silent_p.R66R|MAN2B2_uc011bwf.1_Silent_p.R66R	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	66					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						AGCTGGCCCGCGGCCAGCAGC	0.627													T	6578364	T	T	6578364	2	4	121	1	0	0	0	0	0	0	0	1	9217	755	27	1		1	MAN2B2	4	6578364	Silent	SNP	C	TCGA-12-3652-01A-01D-1495-08		6578364	184575912	18	8338											
PCDH7	5099	broad.mit.edu	37	chr4	30726111	30726111	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aaaaacaccaggccgtacaaGatctaccaccagccaacaca	5	15	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr4:30726111G>T	uc003gsk.1	+	1	4075	c.3067G>T	c.(3067-3069)GAT>TAT	p.D1023Y	PCDH7_uc011bxw.1_Missense_Mutation_p.D976Y|PCDH7_uc011bxx.1_Missense_Mutation_p.D1023Y	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	1023	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GGCCGTACAAGATCTACCACC	0.468													T	30726111	T	T	30726111	3	4	121	1	0	0	0	0	1	0	0	0	11516	942	33	5	3069	5	PCDH7	4	30726111	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	24147747	30726111	160428165	19	8339											
KLB	152831	broad.mit.edu	37	chr4	39435838	39435838	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttcttcttttaggctcactcGaaagtttggcataactacaa	6	9	3	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr4:39435838G>A	uc003gua.2	+	2	931	c.834G>A	c.(832-834)TCG>TCA	p.S278S	KLB_uc011byj.1_Silent_p.S278S	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	278	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						AGGCTCACTCGAAAGTTTGGC	0.413													A	39435838	A	A	39435838	2	1	121	1	0	0	0	0	0	0	0	1	8332	1045	37	2		2	KLB	4	39435838	Silent	SNP	G	TCGA-12-3652-01A-01D-1495-08	8709727	39435838	151718438	20	8340											
NPFFR2	10886	broad.mit.edu	37	chr4	73012972	73012972	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggctcccctctccctcattGtcatcatgtatggaaggatt	8	12	4	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr4:73012972G>T	uc003hgg.2	+	4	1110	c.1012G>T	c.(1012-1014)GTC>TTC	p.V338F	NPFFR2_uc010iig.1_Missense_Mutation_p.V120F|NPFFR2_uc003hgi.2_Missense_Mutation_p.V239F|NPFFR2_uc003hgh.2_Missense_Mutation_p.V236F|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	338	Helical; Name=5; (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			CTCCCTCATTGTCATCATGTA	0.517													T	73012972	T	T	73012972	3	4	121	1	0	0	0	0	1	0	0	0	10578	1377	48	5	1032	5	NPFFR2	4	73012972	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	33577134	73012972	118141304	21	8341											
TMSL3	7117	broad.mit.edu	37	chr4	91760137	91760137	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttgcgtctctgtcttcttcaGtttcggcttatcgaatttct	7	10	5	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr4:91760137G>C	uc003hsy.2	-	1	133	c.52C>G	c.(52-54)CTG>GTG	p.L18V	FAM190A_uc003hsv.3_Intron|FAM190A_uc010ikv.2_Intron|FAM190A_uc003hsx.2_Intron	NM_183049	NP_898870			thymosin-like 3												0		all_cancers(2;6.48e-24)|all_epithelial(2;3.86e-25)|Colorectal(2;8.52e-12)|all_lung(2;3.73e-07)|Lung NSC(2;7.99e-07)|Renal(2;0.0243)|Hepatocellular(203;0.0411)		Epithelial(2;5.28e-11)|OV - Ovarian serous cystadenocarcinoma(123;8.9e-10)|all cancers(2;3.21e-09)|STAD - Stomach adenocarcinoma(1;0.0201)		GTCTTCTTCAGTTTCGGCTTA	0.522													C	91760137	C	C	91760137	3	2	121	1	0	0	0	0	1	0	0	0	16256	1020	36	5	86	5	TMSL3	4	91760137	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	18747165	91760137	99394139	22	8342											
CFI	3426	broad.mit.edu	37	chr4	110663746	110663746	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgaagtgaaaagactctttCgttatctaaacaaagtgaga	8	6	2	4			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr4:110663746C>T	uc003hzr.3	-	12	1643	c.1435G>A	c.(1435-1437)GAA>AAA	p.E479K	CFI_uc003hzq.2_Missense_Mutation_p.E276K|CFI_uc011cft.1_Missense_Mutation_p.E487K|CFI_uc003hzs.3_Missense_Mutation_p.E472K	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	479	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		AAGACTCTTTCGTTATCTAAA	0.338													T	110663746	T	T	110663746	3	4	121	1	0	0	0	0	1	0	0	0	3289	893	31	2	324	2	CFI	4	110663746	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	18903609	110663746	80490530	23	8343											
FAT1	2195	broad.mit.edu	37	chr4	187541102	187541102	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgatgctgtagaacactTtcaggccttccgggctgtta	11	10	1	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr4:187541102T>A	uc003izf.2	-	10	6826	c.6638A>T	c.(6637-6639)AAA>ATA	p.K2213I		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2213	Extracellular (Potential).|Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTAGAACACTTTCAGGCCTTC	0.498										HNSCC(5;0.00058)			A	187541102	A	A	187541102	3	1	121	1	0	0	0	0	1	0	0	0	5689	1841	64	5	7200	5	FAT1	4	187541102	Missense_Mutation	SNP	T	TCGA-12-3652-01A-01D-1495-08	76877356	187541102	3613174	24	8344											
CDH9	1007	broad.mit.edu	37	chr5	26902769	26902769	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtcccaggtgtaagaatcGtggatcagggtgagtgttac	15	6	1	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr5:26902769G>A	uc003jgs.1	-	7	1238	c.1069C>T	c.(1069-1071)CGA>TGA	p.R357*		NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	357	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TGTAAGAATCGTGGATCAGGG	0.358													A	26902769	A	A	26902769	4	1	121	1	0	0	0	0	0	1	0	0	3117	1153	40	1	1324	1	CDH9	5	26902769	Nonsense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		26902769	154012491	25	8345											
MTX3	345778	broad.mit.edu	37	chr5	79284387	79284387	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cttccaggcaggatcaaactCaaaggaaaaggaatttgtga	10	7	2	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr5:79284387C>G	uc010jag.2	-	5	429	c.402G>C	c.(400-402)TTG>TTC	p.L134F	MTX3_uc010jah.2_Missense_Mutation_p.L134F|MTX3_uc003kge.3_Missense_Mutation_p.L73F|MTX3_uc003kgf.1_5'Flank	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	134					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		GGATCAAACTCAAAGGAAAAG	0.453													G	79284387	G	G	79284387	3	3	121	1	0	0	0	0	1	0	0	0	9969	825	29	5	556	5	MTX3	5	79284387	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	52381618	79284387	101630873	26	8346											
GPR98	84059	broad.mit.edu	37	chr5	89943466	89943466	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcattcctgttgaaaaaggAgaaacgctcatttttgaggt	9	6	2	3			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr5:89943466A>G	uc003kju.2	+	17	3270	c.3174A>G	c.(3172-3174)GGA>GGG	p.G1058G	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1058	Calx-beta 8.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGAAAAAGGAGAAACGCTCA	0.413													G	89943466	G	G	89943466	2	3	121	1	0	0	0	0	0	0	0	1	6721	291	11	4		4	GPR98	5	89943466	Silent	SNP	A	TCGA-12-3652-01A-01D-1495-08	10659079	89943466	90971794	27	8347											
PCDHA12	56137	broad.mit.edu	37	chr5	140256668	140256668	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagttccaggtgagcgcGcgcgacgccggcgtgccgcc	16	16	0	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr5:140256668G>A	uc003lic.2	+	1	1738	c.1611G>A	c.(1609-1611)GCG>GCA	p.A537A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.A537A	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	537	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGAGCGCGCGCGACGCCG	0.687													A	140256668	A	A	140256668	2	1	121	1	0	0	0	0	0	0	0	1	11522	1074	38	1		1	PCDHA12	5	140256668	Silent	SNP	G	TCGA-12-3652-01A-01D-1495-08	50313202	140256668	40658592	28	8348											
SIM1	6492	broad.mit.edu	37	chr6	100838896	100838896	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atactgctcagtacgatatcGgtcacctgattcactggccg	9	12	3	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr6:100838896G>A	uc003pqj.3	-	11	1849	c.1642C>T	c.(1642-1644)CGA>TGA	p.R548*	SIM1_uc010kcu.2_Nonsense_Mutation_p.R548*	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	548	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GTACGATATCGGTCACCTGAT	0.428													A	100838896	A	A	100838896	4	1	121	1	0	0	0	0	0	1	0	0	14323	1124	39	2	662	2	SIM1	6	100838896	Nonsense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		100838896	70276171	29	8349											
RFX6	222546	broad.mit.edu	37	chr6	117246619	117246619	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttaaaaactctttccagatgCgagtaaagctgctttcactg	7	9	2	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr6:117246619C>T	uc003pxm.2	+	16	1745	c.1682C>T	c.(1681-1683)GCG>GTG	p.A561V		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	561					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TTTCCAGATGCGAGTAAAGCT	0.393													T	117246619	T	T	117246619	3	4	121	1	0	0	0	0	1	0	0	0	13267	768	27	1	1744	1	RFX6	6	117246619	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	16407723	117246619	53868448	30	8350											
SHPRH	257218	broad.mit.edu	37	chr6	146215353	146215353	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagtaagagcttttgaaataAtatctaatacatcttgccac	5	8	2	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr6:146215353A>G	uc003qlf.2	-	27	5027	c.4628T>C	c.(4627-4629)ATT>ACT	p.I1543T	SHPRH_uc003qld.2_Missense_Mutation_p.I1547T|SHPRH_uc003qle.2_Missense_Mutation_p.I1547T	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1543	Helicase C-terminal.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TTTTGAAATAATATCTAATAC	0.313													G	146215353	G	G	146215353	3	3	121	1	0	0	0	0	1	0	0	0	14291	101	4	4	456	4	SHPRH	6	146215353	Missense_Mutation	SNP	A	TCGA-12-3652-01A-01D-1495-08	28968734	146215353	24899714	31	8351											
SMOC2	64094	broad.mit.edu	37	chr6	169064764	169064764	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcctgctagcccccagaggTcatgctgaaagtacgtctaa	9	12	2	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr6:169064764T>C	uc003qws.1	+	12	1316	c.1296T>C	c.(1294-1296)GGT>GGC	p.G432G	SMOC2_uc003qwr.1_Silent_p.G443G|SMOC2_uc011egu.1_Silent_p.G109G	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	432					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		CCCCCAGAGGTCATGCTGAAA	0.299													C	169064764	C	C	169064764	2	2	121	1	0	0	0	0	0	0	0	1	14802	1654	58	4		4	SMOC2	6	169064764	Silent	SNP	T	TCGA-12-3652-01A-01D-1495-08	22849411	169064764	2050303	32	8352											
NOD1	10392	broad.mit.edu	37	chr7	30492365	30492365	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttgacccctgcgtctagcCggcccgtggcccagaggctc	12	16	1	2	rs139576372		TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr7:30492365C>T	uc003tav.2	-	6	1191	c.668G>A	c.(667-669)CGG>CAG	p.R223Q	NOD1_uc010kvs.2_Intron	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	223	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						TGCGTCTAGCCGGCCCGTGGC	0.577													T	30492365	T	T	30492365	3	4	121	1	0	0	0	0	1	0	0	0	10516	652	23	2	2229	2	NOD1	7	30492365	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08		30492365	128646298	33	8353											
EGFR	1956	broad.mit.edu	37	chr7	55221711	55221711	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctctcctccataggtctgccGcaaattccgagacgaagcca	8	15	2	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr7:55221711G>C	uc003tqk.2	+	7	1001	c.755G>C	c.(754-756)CGC>CCC	p.R252P	EGFR_uc003tqh.2_Missense_Mutation_p.R252P|EGFR_uc003tqi.2_Missense_Mutation_p.R252P|EGFR_uc003tqj.2_Missense_Mutation_p.R252P|EGFR_uc010kzg.1_Missense_Mutation_p.R207P|EGFR_uc011kco.1_Missense_Mutation_p.R199P|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	252	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.R252C(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TAGGTCTGCCGCAAATTCCGA	0.587		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			C	55221711	C	C	55221711	3	2	121	1	0	0	0	0	1	0	0	0	4967	1087	38	5	781	5	EGFR	7	55221711	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	24729346	55221711	103916952	34	8354											
WNT2	7472	broad.mit.edu	37	chr7	116960680	116960680	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagggtgttgcaattccagCggtgctggcggaactggtgc	16	10	0	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr7:116960680C>T	uc003viz.2	-	2	551	c.251G>A	c.(250-252)CGC>CAC	p.R84H	WNT2_uc003vja.2_Silent_p.P9P	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	84					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GCAATTCCAGCGGTGCTGGCG	0.597													T	116960680	T	T	116960680	3	4	121	1	0	0	0	0	1	0	0	0	17383	768	27	1	847	1	WNT2	7	116960680	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	61738969	116960680	42177983	35	8355											
MGAM	8972	broad.mit.edu	37	chr7	141734061	141734061	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgatcctgcttttgtttcaGgaatcctggatgggtacctg	11	8	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr7:141734061G>T	uc003vwy.2	+	15	1724	c.1670_splice	c.e15-1	p.R557_splice		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase						polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTTTGTTTCAGGAATCCTGGA	0.478													T	141734061	T	T	141734061	5	4	121	1	0	0	0	0	0	0	1	0	9541	1014	35	5	1723	5	MGAM	7	141734061	Splice_Site	SNP	G	TCGA-12-3652-01A-01D-1495-08	24773381	141734061	17404602	36	8356											
FAM135B	51059	broad.mit.edu	37	chr8	139164563	139164563	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccggtggagggcatgtcttcGaacaaacgggtgcaagactt	14	9	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr8:139164563G>A	uc003yuy.2	-	13	2326	c.2155C>T	c.(2155-2157)CGA>TGA	p.R719*	FAM135B_uc003yux.2_Nonsense_Mutation_p.R620*|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Nonsense_Mutation_p.R281*|FAM135B_uc003yvb.2_Nonsense_Mutation_p.R281*	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	719										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCATGTCTTCGAACAAACGGG	0.567										HNSCC(54;0.14)			A	139164563	A	A	139164563	4	1	121	1	0	0	0	0	0	1	0	0	5449	1066	37	2	2097	2	FAM135B	8	139164563	Nonsense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		139164563	7199459	37	8357											
BNC2	54796	broad.mit.edu	37	chr9	16419622	16419622	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttctttggtcaacagtttacGatgtaggtttatgttggcac	10	6	2	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr9:16419622G>A	uc003zml.2	-	7	2805	c.2665C>T	c.(2665-2667)CGT>TGT	p.R889C	BNC2_uc011lmw.1_Missense_Mutation_p.R794C|BNC2_uc003zmm.2_3'UTR|BNC2_uc011lmv.1_3'UTR|BNC2_uc003zmj.2_3'UTR|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.R676C	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	889					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		AACAGTTTACGATGTAGGTTT	0.488													A	16419622	A	A	16419622	3	1	121	1	0	0	0	0	1	0	0	0	1475	1058	37	2	638	2	BNC2	9	16419622	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		16419622	124793809	38	8358											
LINGO2	158038	broad.mit.edu	37	chr9	27950347	27950347	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccttttaggcggagggaaCgcaggttaaagagattgttg	15	5	0	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr9:27950347C>T	uc003zqu.1	-	2	517	c.323G>A	c.(322-324)CGT>CAT	p.R108H	LINGO2_uc010mjf.1_Missense_Mutation_p.R108H|LINGO2_uc003zqv.1_Missense_Mutation_p.R108H	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	108	LRR 3.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		GCGGAGGGAACGCAGGTTAAA	0.438													T	27950347	T	T	27950347	3	4	121	1	0	0	0	0	1	0	0	0	8815	536	19	1	1501	1	LINGO2	9	27950347	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	11530725	27950347	113263084	39	8359											
WNK2	65268	broad.mit.edu	37	chr9	96051416	96051416	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcaccttgcactccagctccAgaggctgcctcaaccaggga	10	16	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr9:96051416A>G	uc004ati.1	+	20	4491	c.4491A>G	c.(4489-4491)CCA>CCG	p.P1497P	WNK2_uc011lud.1_Silent_p.P1460P|WNK2_uc004atj.2_Silent_p.P1460P|WNK2_uc004atk.2_Silent_p.P1097P|WNK2_uc004atl.1_Silent_p.P55P	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1497					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CTCCAGCTCCAGAGGCTGCCT	0.692													G	96051416	G	G	96051416	2	3	121	1	0	0	0	0	0	0	0	1	17375	175	7	4		4	WNK2	9	96051416	Silent	SNP	A	TCGA-12-3652-01A-01D-1495-08	68101069	96051416	45162015	40	8360											
OR9G9	504191	broad.mit.edu	37	chr11	56467944	56467944	+	Frame_Shift_Del	DEL	C	-	-													ggaatgcagctgggcctcttCgtggtgttcctgggcgtgta							TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr11:56467944delC	uc010rjn.1	+	1	81	c.81delC	c.(79-81)TTCfs	p.F27fs		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	27	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGGCCTCTTCGTGGTGTTCC	0.502													-	56467944	-	-	56467944	7	5	121	1	0	1	0	1	0	0	0	0	11252	883	31	0	83	0	OR9G9	11	56467944	Frame_Shift_Del	DEL	C	TCGA-12-3652-01A-01D-1495-08		56467944	78538572	41	8361											
LRRC55	219527	broad.mit.edu	37	chr11	56949854	56949854	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgcttggcacacttggacCtgagctacaacaatttcagc	9	12	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr11:56949854C>T	uc001njl.1	+	1	634	c.487C>T	c.(487-489)CTG>TTG	p.L163L		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	133	LRR 3.					integral to membrane					0						ACACTTGGACCTGAGCTACAA	0.582													T	56949854	T	T	56949854	2	4	121	1	0	0	0	0	0	0	0	1	9011	680	24	3		3	LRRC55	11	56949854	Silent	SNP	C	TCGA-12-3652-01A-01D-1495-08	481910	56949854	78056662	42	8362											
OR5AN1	390195	broad.mit.edu	37	chr11	59132440	59132440	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tttgcttcaactccacttctGtgggtctaatgtcatcagac	7	11	5	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr11:59132440G>T	uc010rks.1	+	1	509	c.509G>T	c.(508-510)TGT>TTT	p.C170F		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTCCACTTCTGTGGGTCTAAT	0.443													T	59132440	T	T	59132440	3	4	121	1	0	0	0	0	1	0	0	0	11143	1377	48	5	511	5	OR5AN1	11	59132440	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	2182586	59132440	75874076	43	8363											
MMP13	4322	broad.mit.edu	37	chr11	102822878	102822878	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggagtggccgaactcatgcGcagcaacaagaaacaagttg	12	9	1	1	rs147544761		TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr11:102822878G>A	uc001phl.2	-	5	690	c.662C>T	c.(661-663)GCG>GTG	p.A221V		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	221					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GAACTCATGCGCAGCAACAAG	0.423													A	102822878	A	A	102822878	3	1	121	1	0	0	0	0	1	0	0	0	9652	1087	38	1	777	1	MMP13	11	102822878	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	43690438	102822878	32183638	44	8364											
GRIN2B	2904	broad.mit.edu	37	chr12	13724856	13724856	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctgccgttgggcacggTcccaaagcggaaagggggtg	18	9	0	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr12:13724856T>C	uc001rbt.2	-	10	2232	c.2053A>G	c.(2053-2055)ACC>GCC	p.T685A		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	685	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGGGCACGGTCCCAAAGCGG	0.353													C	13724856	C	C	13724856	3	2	121	1	0	0	0	0	1	0	0	0	6780	1667	58	4	2417	4	GRIN2B	12	13724856	Missense_Mutation	SNP	T	TCGA-12-3652-01A-01D-1495-08		13724856	120127039	45	8365											
NR4A1	3164	broad.mit.edu	37	chr12	52448556	52448556	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tccacgcccagcttccagccGccccagctctctccctggga	8	21	1	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr12:52448556G>T	uc001rzs.2	+	3	758	c.444G>T	c.(442-444)CCG>CCT	p.P148P	NR4A1_uc010sno.1_Silent_p.P161P|NR4A1_uc001rzr.2_Silent_p.P148P|NR4A1_uc009zmb.1_Silent_p.P148P|NR4A1_uc001rzt.2_Silent_p.P148P|NR4A1_uc009zmc.2_5'Flank	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	148					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GCTTCCAGCCGCCCCAGCTCT	0.677													T	52448556	T	T	52448556	2	4	121	1	0	0	0	0	0	0	0	1	10632	1074	38	5		5	NR4A1	12	52448556	Silent	SNP	G	TCGA-12-3652-01A-01D-1495-08	38723700	52448556	81403339	46	8366											
ESYT1	23344	broad.mit.edu	37	chr12	56536179	56536179	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tttacactcagcagtggtcaGgggcaggtgctactgagagc	14	9	2	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr12:56536179G>T	uc001sjq.2	+	25	2753	c.2703G>T	c.(2701-2703)CAG>CAT	p.Q901H	ESYT1_uc001sjr.2_Missense_Mutation_p.Q911H	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	901						integral to membrane				ovary(4)|skin(1)	5						GCAGTGGTCAGGGGCAGGTGC	0.622													T	56536179	T	T	56536179	3	4	121	1	0	0	0	0	1	0	0	0	5264	991	35	5	2831	5	ESYT1	12	56536179	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	4087623	56536179	77315716	47	8367											
RNFT2	84900	broad.mit.edu	37	chr12	117217036	117217036	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccaacctggagatgctggaCttctttgacctgctatggat	10	11	1	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr12:117217036C>T	uc009zwn.2	+	7	998	c.765C>T	c.(763-765)GAC>GAT	p.D255D	RNFT2_uc001twb.3_Silent_p.D255D|RNFT2_uc001twa.3_Silent_p.D165D|RNFT2_uc001twc.3_Silent_p.D3D	NM_001109903	NP_001103373	Q96EX2	RNFT2_HUMAN	transmembrane protein 118 isoform 1	255	Extracellular (Potential).					integral to membrane	zinc ion binding				0	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		AGATGCTGGACTTCTTTGACC	0.547													T	117217036	T	T	117217036	2	4	121	1	0	0	0	0	0	0	0	1	13502	564	20	3		3	RNFT2	12	117217036	Silent	SNP	C	TCGA-12-3652-01A-01D-1495-08	60680857	117217036	16634859	48	8368											
VSIG10	54621	broad.mit.edu	37	chr12	118517207	118517207	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caactatgtggcttgtaacaCacttgaacttcttgccatcc	6	12	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr12:118517207C>A	uc001tws.2	-	4	1203	c.869G>T	c.(868-870)TGT>TTT	p.C290F		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	290	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane					0						GCTTGTAACACACTTGAACTT	0.542													A	118517207	A	A	118517207	3	1	121	1	0	0	0	0	1	0	0	0	17220	478	17	5	777	5	VSIG10	12	118517207	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	1300171	118517207	15334688	49	8369											
CCDC60	160777	broad.mit.edu	37	chr12	119942953	119942953	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccacactcagtctgagtcGggccagtggggggtcctctc	13	14	3	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr12:119942953G>A	uc001txe.2	+	7	1193	c.728G>A	c.(727-729)CGG>CAG	p.R243Q	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	243										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		AGTCTGAGTCGGGCCAGTGGG	0.557													A	119942953	A	A	119942953	3	1	121	1	0	0	0	0	1	0	0	0	2831	1116	39	2	754	2	CCDC60	12	119942953	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	1425746	119942953	13908942	50	8370											
RNF17	56163	broad.mit.edu	37	chr13	25425654	25425654	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagagatgaaaaaggagagCgtgttgatgtttctaaatat	12	3	1	4			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr13:25425654C>T	uc001upr.2	+	24	3306	c.3265C>T	c.(3265-3267)CGT>TGT	p.R1089C	RNF17_uc010tdd.1_Missense_Mutation_p.R948C|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.R1085C|RNF17_uc001ups.2_Missense_Mutation_p.R1028C|RNF17_uc010aac.2_Missense_Mutation_p.R287C|RNF17_uc010aad.2_Missense_Mutation_p.R141C	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1089					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AAAAGGAGAGCGTGTTGATGT	0.333													T	25425654	T	T	25425654	3	4	121	1	0	0	0	0	1	0	0	0	13461	768	27	1	3359	1	RNF17	13	25425654	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08		25425654	89744224	51	8371											
PCDH9	5101	broad.mit.edu	37	chr13	67205380	67205380	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgccatctgcttcagtcctcTtgtccggagaggcctggtca	11	13	4	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr13:67205380T>C	uc001vik.2	-	4	3994	c.3302A>G	c.(3301-3303)AAG>AGG	p.K1101R	PCDH9_uc010aei.2_RNA|PCDH9_uc001vil.2_Missense_Mutation_p.K1067R|PCDH9_uc010thl.1_Missense_Mutation_p.K1059R	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	1101	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TTCAGTCCTCTTGTCCGGAGA	0.512													C	67205380	C	C	67205380	3	2	121	1	0	0	0	0	1	0	0	0	11518	1609	56	4	419	4	PCDH9	13	67205380	Missense_Mutation	SNP	T	TCGA-12-3652-01A-01D-1495-08	41779726	67205380	47964498	52	8372											
KLF12	11278	broad.mit.edu	37	chr13	74387376	74387376	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggcaggtcatcatcatcaCtgtcacttttactttgtctg	7	10	6	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr13:74387376C>T	uc001vjf.2	-	5	941	c.719G>A	c.(718-720)AGT>AAT	p.S240N	KLF12_uc010aeq.2_Missense_Mutation_p.S240N|KLF12_uc001vjg.3_Missense_Mutation_p.S240N	NM_007249	NP_009180	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	240					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		ATCATCATCACTGTCACTTTT	0.423													T	74387376	T	T	74387376	3	4	121	1	0	0	0	0	1	0	0	0	8340	565	20	3	505	3	KLF12	13	74387376	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	7181996	74387376	40782502	53	8373											
HEATR5A	25938	broad.mit.edu	37	chr14	31852888	31852888	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttaggtaggagggtaatgCcacggcaatgcagtgtaaac	14	6	0	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr14:31852888C>T	uc001wrf.3	-	4	633	c.556G>A	c.(556-558)GCA>ACA	p.A186T	HEATR5A_uc010ami.2_Missense_Mutation_p.A84T|HEATR5A_uc001wrg.1_Missense_Mutation_p.A68T|HEATR5A_uc010tpk.1_Missense_Mutation_p.A479T	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	473							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		GAGGGTAATGCCACGGCAATG	0.468													T	31852888	T	T	31852888	3	4	121	1	0	0	0	0	1	0	0	0	7031	739	26	3	4813	3	HEATR5A	14	31852888	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08		31852888	75496652	54	8374											
RYR3	6263	broad.mit.edu	37	chr15	34049760	34049760	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaagccccttagcagcagcGgatatgcctcccataaggag	11	12	0	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr15:34049760G>A	uc001zhi.2	+	60	8738	c.8668G>A	c.(8668-8670)GGA>AGA	p.G2890R	RYR3_uc010bar.2_Missense_Mutation_p.G2890R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2890	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TAGCAGCAGCGGATATGCCTC	0.512													A	34049760	A	A	34049760	3	1	121	1	0	0	0	0	1	0	0	0	13770	1117	39	2	8906	2	RYR3	15	34049760	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		34049760	68481632	55	8375											
SPTBN5	51332	broad.mit.edu	37	chr15	42162053	42162053	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcaccgccgtgcggaagcGggccaggaggcgtgcccgct	16	16	1	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr15:42162053G>A	uc001zos.2	-	32	6067	c.5734C>T	c.(5734-5736)CGC>TGC	p.R1912C		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1947	Spectrin 16.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GTGCGGAAGCGGGCCAGGAGG	0.682													A	42162053	A	A	42162053	3	1	121	1	0	0	0	0	1	0	0	0	15121	1116	39	2	5333	2	SPTBN5	15	42162053	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	8112293	42162053	60369339	56	8376											
GALK2	2585	broad.mit.edu	37	chr15	49620177	49620177	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggctcaagggtcacgacttActggagcaggatggggaggc	18	8	2	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr15:49620177A>G	uc001zxj.1	+	10	1296	c.1198A>G	c.(1198-1200)ACT>GCT	p.T400A	GALK2_uc001zxi.1_Missense_Mutation_p.T389A|GALK2_uc010ufb.1_Missense_Mutation_p.T376A|GALK2_uc001zxk.2_RNA|GALK2_uc010ufc.1_Missense_Mutation_p.T376A	NM_002044	NP_002035	Q01415	GALK2_HUMAN	galactokinase 2 isoform 1	400					galactose metabolic process	cytoplasm	ATP binding|galactokinase activity|N-acetylgalactosamine kinase activity			breast(1)	1		all_lung(180;0.000325)		all cancers(107;3.71e-08)|GBM - Glioblastoma multiforme(94;7e-05)		GTCACGACTTACTGGAGCAGG	0.438													G	49620177	G	G	49620177	3	3	121	1	0	0	0	0	1	0	0	0	6204	391	14	4	1260	4	GALK2	15	49620177	Missense_Mutation	SNP	A	TCGA-12-3652-01A-01D-1495-08	7458124	49620177	52911215	57	8377											
SLC24A1	9187	broad.mit.edu	37	chr15	65917215	65917215	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctgacacatgaggtagaagCaaacgtcttgacttctccaa	8	10	3	4			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr15:65917215C>A	uc010ujf.1	+	2	1084	c.797C>A	c.(796-798)GCA>GAA	p.A266E	SLC24A1_uc010ujd.1_Missense_Mutation_p.A266E|SLC24A1_uc010uje.1_Missense_Mutation_p.A266E|SLC24A1_uc010ujg.1_Missense_Mutation_p.A266E|SLC24A1_uc010ujh.1_Missense_Mutation_p.A266E	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	266	Extracellular (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						GAGGTAGAAGCAAACGTCTTG	0.473													A	65917215	A	A	65917215	3	1	121	1	0	0	0	0	1	0	0	0	14465	710	25	5		5	SLC24A1	15	65917215	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	16297038	65917215	36614177	58	8378											
MYO15A	51168	broad.mit.edu	37	chr17	18052554	18052554	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgggaacagctgggactcGgatgaggacatgtccactag	14	8	0	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr17:18052554G>A	uc010vxh.1	+	33	7319	c.6981G>A	c.(6979-6981)TCG>TCA	p.S2327S		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2327	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCTGGGACTCGGATGAGGACA	0.512													A	18052554	A	A	18052554	2	1	121	1	0	0	0	0	0	0	0	1	10063	1103	39	2		2	MYO15A	17	18052554	Silent	SNP	G	TCGA-12-3652-01A-01D-1495-08		18052554	63142656	59	8379											
MYO1D	4642	broad.mit.edu	37	chr17	31107790	31107790	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaatgaacgtatagatgcgCcctttttcaaatctgtacag	7	10	2	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr17:31107790C>T	uc002hho.1	-	2	120	c.108G>A	c.(106-108)GGG>GGA	p.G36G	MYO1D_uc002hhp.1_Silent_p.G36G|MYO1D_uc010wcb.1_Silent_p.G36G	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	36	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			TATAGATGCGCCCTTTTTCAA	0.413													T	31107790	T	T	31107790	2	4	121	1	0	0	0	0	0	0	0	1	10071	726	26	3		3	MYO1D	17	31107790	Silent	SNP	C	TCGA-12-3652-01A-01D-1495-08	13055236	31107790	50087420	60	8380											
SLC4A1	6521	broad.mit.edu	37	chr17	42335421	42335421	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atgaagatgacggcagccagGacctgggggctgaatgcatc	15	9	0	4			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr17:42335421G>A	uc002igf.3	-	11	1364	c.1215C>T	c.(1213-1215)GTC>GTT	p.V405V	SLC4A1_uc002igg.3_Silent_p.V405V	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	405	Helical; (Potential).|Membrane (anion exchange).		Missing (in EL4).		bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CGGCAGCCAGGACCTGGGGGC	0.597													A	42335421	A	A	42335421	2	1	121	1	0	0	0	0	0	0	0	1	14650	1161	41	3		3	SLC4A1	17	42335421	Silent	SNP	G	TCGA-12-3652-01A-01D-1495-08	11227631	42335421	38859789	61	8381											
RBBP8	5932	broad.mit.edu	37	chr18	20564928	20564928	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attctagtagctgacacttaTgaccaaagtcaatctccaat	5	10	3	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr18:20564928T>C	uc002ktw.2	+	8	1015	c.684T>C	c.(682-684)TAT>TAC	p.Y228Y	RBBP8_uc002kty.2_Silent_p.Y228Y|RBBP8_uc002ktz.2_Silent_p.Y228Y|RBBP8_uc002kua.2_Silent_p.Y228Y|RBBP8_uc002ktx.1_Silent_p.Y228Y	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	228					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			CTGACACTTATGACCAAAGTC	0.353								Direct_reversal_of_damage|Homologous_recombination					C	20564928	C	C	20564928	2	2	121	1	0	0	0	0	0	0	0	1	13105	1471	51	4		4	RBBP8	18	20564928	Silent	SNP	T	TCGA-12-3652-01A-01D-1495-08		20564928	57512320	62	8382											
C3	718	broad.mit.edu	37	chr19	6677900	6677900	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aatgggggtgtggtcagttgGggcacccaaagacaaccatg	15	8	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr19:6677900G>T	uc002mfm.2	-	41	5047	c.4985C>A	c.(4984-4986)CCC>CAC	p.P1662H	C3_uc002mfl.2_Missense_Mutation_p.P398H	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1662					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGGTCAGTTGGGGCACCCAAA	0.557													T	6677900	T	T	6677900	3	4	121	1	0	0	0	0	1	0	0	0	2204	1232	43	5	10	5	C3	19	6677900	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		6677900	52451083	63	8383											
FKBP8	23770	broad.mit.edu	37	chr19	18649190	18649190	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcaggcccgtccacagccGtcttcagggtcacctccagg	12	16	4	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr19:18649190G>A	uc002njk.1	-	5	718	c.605C>T	c.(604-606)ACG>ATG	p.T202M	FKBP8_uc002nji.1_Missense_Mutation_p.T40M|FKBP8_uc010xqi.1_Missense_Mutation_p.T231M|FKBP8_uc002njj.1_Missense_Mutation_p.T203M|FKBP8_uc002njl.1_Missense_Mutation_p.T203M|FKBP8_uc002njm.1_Missense_Mutation_p.T202M|FKBP8_uc010ebr.1_Missense_Mutation_p.T41M|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	202	PPIase FKBP-type.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						GTCCACAGCCGTCTTCAGGGT	0.697													A	18649190	A	A	18649190	3	1	121	1	0	0	0	0	1	0	0	0	5914	1145	40	1	653	1	FKBP8	19	18649190	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	11971290	18649190	40479793	64	8384											
TMEM147	10430	broad.mit.edu	37	chr19	36037641	36037641	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttgtcatgtcccggaatgCcggcaagggagagtacaaga	13	10	1	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr19:36037641C>T	uc002oaj.1	+	4	372	c.275C>T	c.(274-276)GCC>GTC	p.A92V	uc010eec.1_5'Flank|uc002oag.2_5'Flank|TMEM147_uc002oai.1_Missense_Mutation_p.A43V|TMEM147_uc002oak.1_Missense_Mutation_p.P2S	NM_032635	NP_116024	Q9BVK8	TM147_HUMAN	transmembrane protein 147	92						endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TCCCGGAATGCCGGCAAGGGA	0.572													T	36037641	T	T	36037641	3	4	121	1	0	0	0	0	1	0	0	0	16058	739	26	3	289	3	TMEM147	19	36037641	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	17388451	36037641	23091342	65	8385											
NPHS1	4868	broad.mit.edu	37	chr19	36339161	36339161	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaggggctcacattttaCgttcaggatgagcgacttct	13	9	3	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr19:36339161C>T	uc002oby.2	-	10	1309	c.1309G>A	c.(1309-1311)GTA>ATA	p.V437I		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	437	Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCACATTTTACGTTCAGGATG	0.582													T	36339161	T	T	36339161	3	4	121	1	0	0	0	0	1	0	0	0	10582	536	19	1	2496	1	NPHS1	19	36339161	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	301520	36339161	22789822	66	8386											
TTYH1	57348	broad.mit.edu	37	chr19	54930375	54930375	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttcatcgctgtctacctcaTccgcttctgctgctgccggc	8	16	4	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr19:54930375T>C	uc002qfq.2	+	2	292	c.200T>C	c.(199-201)ATC>ACC	p.I67T	TTYH1_uc010yey.1_Missense_Mutation_p.I116T|TTYH1_uc002qfr.2_Missense_Mutation_p.I67T|TTYH1_uc002qft.2_Missense_Mutation_p.I67T|TTYH1_uc002qfu.1_5'UTR	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	67	Cytoplasmic (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GTCTACCTCATCCGCTTCTGC	0.682													C	54930375	C	C	54930375	3	2	121	1	0	0	0	0	1	0	0	0	16736	1435	50	4	206	4	TTYH1	19	54930375	Missense_Mutation	SNP	T	TCGA-12-3652-01A-01D-1495-08	18591214	54930375	4198608	67	8387											
ZNF418	147686	broad.mit.edu	37	chr19	58441862	58441862	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaggcatctctgaacctcacTaaggagactccactcctcct	6	15	2	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr19:58441862T>A	uc002qqs.1	-	3	359	c.67A>T	c.(67-69)AGT>TGT	p.S23C	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Intron	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	23	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TGAACCTCACTAAGGAGACTC	0.483													A	58441862	A	A	58441862	3	1	121	1	0	0	0	0	1	0	0	0	17892	1522	53	5	1971	5	ZNF418	19	58441862	Missense_Mutation	SNP	T	TCGA-12-3652-01A-01D-1495-08	3511487	58441862	687121	68	8388											
PROKR2	128674	broad.mit.edu	37	chr20	5283335	5283335	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcgatcaggaaggaggccGtttgataattcatccgtggt	14	7	2	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr20:5283335G>A	uc010zqw.1	-	2	506	c.506C>T	c.(505-507)ACG>ATG	p.T169M	PROKR2_uc010zqx.1_Missense_Mutation_p.T169M|PROKR2_uc010zqy.1_Missense_Mutation_p.T169M	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	169	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GAAGGAGGCCGTTTGATAATT	0.488										HNSCC(71;0.22)			A	5283335	A	A	5283335	3	1	121	1	0	0	0	0	1	0	0	0	12553	1145	40	1	651	1	PROKR2	20	5283335	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		5283335	57742185	69	8389											
SEMG2	6407	broad.mit.edu	37	chr20	43851266	43851266	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagtctcaaaaccaggtaacAattcatagtcaagatcaaga	6	8	4	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr20:43851266A>G	uc010ggz.2	+	2	1050	c.993A>G	c.(991-993)ACA>ACG	p.T331T	SEMG2_uc002xnk.2_Silent_p.T331T|SEMG2_uc002xnl.2_Silent_p.T331T	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	331	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				ACCAGGTAACAATTCATAGTC	0.373													G	43851266	G	G	43851266	2	3	121	1	0	0	0	0	0	0	0	1	14045	117	5	4		4	SEMG2	20	43851266	Silent	SNP	A	TCGA-12-3652-01A-01D-1495-08	38567931	43851266	19174254	70	8390											
WFDC8	90199	broad.mit.edu	37	chr20	44180784	44180784	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtacatagcaagggcttgcGtgggcagaaaccttttttga	13	7	0	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr20:44180784G>A	uc002xow.2	-	6	686	c.607C>T	c.(607-609)CGC>TGC	p.R203C	WFDC8_uc002xox.2_Missense_Mutation_p.R203C	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	203	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				AAGGGCTTGCGTGGGCAGAAA	0.423													A	44180784	A	A	44180784	3	1	121	1	0	0	0	0	1	0	0	0	17353	1145	40	1	122	1	WFDC8	20	44180784	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08	329518	44180784	18844736	71	8391											
MOCS3	27304	broad.mit.edu	37	chr20	49575846	49575846	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcggcagtggaatgcgtgcCgtacactcaggcccttacgc	12	13	1	0			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr20:49575846C>T	uc002xvy.1	+	1	484	c.467C>T	c.(466-468)CCG>CTG	p.P156L	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	156					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						GAATGCGTGCCGTACACTCAG	0.657													T	49575846	T	T	49575846	3	4	121	1	0	0	0	0	1	0	0	0	9692	652	23	2	469	2	MOCS3	20	49575846	Missense_Mutation	SNP	C	TCGA-12-3652-01A-01D-1495-08	5395062	49575846	13449674	72	8392											
UMODL1	89766	broad.mit.edu	37	chr21	43496188	43496188	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctgtacagaaggtggaggccGtgcagacgtcctacacgtcc	13	12	0	2			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chr21:43496188G>C	uc002zaf.1	+	2	151	c.151G>C	c.(151-153)GTG>CTG	p.V51L	UMODL1_uc002zad.1_5'UTR|UMODL1_uc002zae.1_5'UTR|UMODL1_uc002zag.1_Missense_Mutation_p.V51L|uc002zah.1_RNA	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	51	Extracellular (Potential).|EMI.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						GGTGGAGGCCGTGCAGACGTC	0.587													C	43496188	C	C	43496188	3	2	121	1	0	0	0	0	1	0	0	0	16977	1145	40	5	157	5	UMODL1	21	43496188	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		43496188	4633707	73	8393											
MAGEB4	4115	broad.mit.edu	37	chrX	30260502	30260502	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcactggatctgataaaggcGacgagagccaagatgaggaa	14	7	1	4			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chrX:30260502G>A	uc004dcb.2	+	1	334	c.250G>A	c.(250-252)GAC>AAC	p.D84N	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	84										ovary(1)	1						TGATAAAGGCGACGAGAGCCA	0.517													A	30260502	A	A	30260502	3	1	121	1	0	0	0	0	1	0	0	0	9178	1058	37	2	252	2	MAGEB4	23	30260502	Missense_Mutation	SNP	G	TCGA-12-3652-01A-01D-1495-08		30260502	125010058	74	8394											
AR	367	broad.mit.edu	37	chrX	66937441	66937441	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aactccaggatgctctacttCgcccctgatctggttttcaa	7	13	3	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chrX:66937441C>T	uc004dwu.1	+	5	3410	c.2295C>T	c.(2293-2295)TTC>TTT	p.F765F	AR_uc004dwv.1_Silent_p.F233F	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	764	Ligand-binding.|Interaction with MYST2.		F -> L (in AIS).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TGCTCTACTTCGCCCCTGATC	0.542									Androgen_Insensitivity_Syndrome				T	66937441	T	T	66937441	2	4	121	1	0	0	0	0	0	0	0	1	836	883	31	2		2	AR	23	66937441	Silent	SNP	C	TCGA-12-3652-01A-01D-1495-08	36676939	66937441	88333119	75	8395											
KDM5D	8284	broad.mit.edu	37	chrY	21897252	21897252	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccttacaaactgggcactgcTgtgattctttcgaagttgca	9	10	1	1			TCGA-12-3652-01A-01D-1495-08	TCGA-12-3652-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	ab460bc2-e504-4b7f-8533-ab06448a55bc	efb5f9b6-2243-41ed-aedc-4e3ab39ce2b0	g.chrY:21897252T>A	uc004fug.2	-	8	1207	c.919A>T	c.(919-921)AGC>TGC	p.S307C	KDM5D_uc011naz.1_Missense_Mutation_p.S307C|KDM5D_uc010nwy.2_Missense_Mutation_p.S250C|KDM5D_uc011nba.1_Missense_Mutation_p.S307C|KDM5D_uc004fuh.2_Missense_Mutation_p.S262C	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	307					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	TGGGCACTGCTGTGATTCTTT	0.398													A	21897252	A	A	21897252	3	1	121	1	0	0	0	0	1	0	0	0	8136	1580	55	5	3877	5	KDM5D	24	21897252	Missense_Mutation	SNP	T	TCGA-12-3652-01A-01D-1495-08		21897252	37476314	76	8396											
KIAA1751	85452	broad.mit.edu	37	chr1	1900084	1900084	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttgctcaccagtgtgtacGtgttggttgggactgtggtc	14	7	1	0	rs150108692	by1000genomes	TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr1:1900084G>A	uc001aim.1	-	11	1391	c.1235C>T	c.(1234-1236)ACG>ATG	p.T412M	KIAA1751_uc009vkz.1_Missense_Mutation_p.T412M	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	412										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CAGTGTGTACGTGTTGGTTGG	0.582													A	1900084	A	A	1900084	3	1	122	1	0	0	0	0	1	0	0	0	8256	1145	40	1	1085	1	KIAA1751	1	1900084	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08		1900084	247350537	1	8397											
MTF1	4520	broad.mit.edu	37	chr1	38323155	38323155	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtccgtcgtcatcttcatccTccaaagtgccagggtcctgc	9	15	3	0			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr1:38323155T>C	uc001cce.1	-	2	317	c.176A>G	c.(175-177)GAG>GGG	p.E59G	MTF1_uc009vvj.1_5'UTR	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	59						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ATCTTCATCCTCCAAAGTGCC	0.488													C	38323155	C	C	38323155	3	2	122	1	0	0	0	0	1	0	0	0	9922	1551	54	4	2125	4	MTF1	1	38323155	Missense_Mutation	SNP	T	TCGA-12-3653-01A-01D-1495-08	36423071	38323155	210927466	2	8398											
WDR65	149465	broad.mit.edu	37	chr1	43649424	43649424	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctgatgacaagattgtcGttggcactgacacaggcaaa	12	8	0	4	rs142914910		TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr1:43649424G>A	uc001cip.1	+	4	758	c.637G>A	c.(637-639)GTT>ATT	p.V213I	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Missense_Mutation_p.V202I|WDR65_uc001ciq.1_Missense_Mutation_p.V213I	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	213	WD 3.									skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CAAGATTGTCGTTGGCACTGA	0.502													A	43649424	A	A	43649424	3	1	122	1	0	0	0	0	1	0	0	0	17313	1145	40	1	647	1	WDR65	1	43649424	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08	5326269	43649424	205601197	3	8399											
RAD54L	8438	broad.mit.edu	37	chr1	46726266	46726266	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctattctcagtaaggttttgCggcctcatcagagagaggta	11	8	3	2	rs149141765		TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr1:46726266C>T	uc009vye.2	+	7	574	c.460C>T	c.(460-462)CGG>TGG	p.R154W	RAD54L_uc001cpl.2_Missense_Mutation_p.R154W|RAD54L_uc001cpm.1_5'UTR	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	154					meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		TAAGGTTTTGCGGCCTCATCA	0.537								Direct_reversal_of_damage|Homologous_recombination					T	46726266	T	T	46726266	3	4	122	1	0	0	0	0	1	0	0	0	12993	759	27	1	482	1	RAD54L	1	46726266	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	3076842	46726266	202524355	4	8400											
LMX1A	4009	broad.mit.edu	37	chr1	165177351	165177351	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgctgctgctgctgctgtcGcctggccagcttcttcatct	10	14	3	0			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr1:165177351G>A	uc001gcy.1	-	6	987	c.766C>T	c.(766-768)CGA>TGA	p.R256*	LMX1A_uc001gcz.1_Nonsense_Mutation_p.R256*|LMX1A_uc001gcw.1_5'UTR|LMX1A_uc001gcx.1_Nonsense_Mutation_p.R7*	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	256	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					TGCTGCTGTCGCCTGGCCAGC	0.562													A	165177351	A	A	165177351	4	1	122	1	0	0	0	0	0	1	0	0	8861	1095	38	1	394	1	LMX1A	1	165177351	Nonsense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08	118451085	165177351	84073270	5	8401											
CDC42EP3	10602	broad.mit.edu	37	chr2	37873026	37873026	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtgagggcccaagatcaagCtgcagggagaggagggaacc	17	8	1	3			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr2:37873026C>A	uc002rqi.1	-	2	1698	c.705G>T	c.(703-705)CAG>CAT	p.Q235H		NM_006449	NP_006440	Q9UKI2	BORG2_HUMAN	Cdc42 effector protein 3	235					regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding				0		all_hematologic(82;0.172)				CAAGATCAAGCTGCAGGGAGA	0.463													A	37873026	A	A	37873026	3	1	122	1	0	0	0	0	1	0	0	0	3077	796	28	5	63	5	CDC42EP3	2	37873026	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08		37873026	205326347	6	8402											
LRP1B	53353	broad.mit.edu	37	chr2	141130669	141130669	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacactgaccattggaacacCggaactgatctttggaacaa	8	10	1	2	rs145915063		TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr2:141130669C>T	uc002tvj.1	-	69	11648	c.10676G>A	c.(10675-10677)CGG>CAG	p.R3559Q		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3559	Extracellular (Potential).|LDL-receptor class A 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTGGAACACCGGAACTGATC	0.368										TSP Lung(27;0.18)			T	141130669	T	T	141130669	3	4	122	1	0	0	0	0	1	0	0	0	8955	652	23	2	3215	2	LRP1B	2	141130669	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	103257643	141130669	102068704	7	8403											
DFNB59	494513	broad.mit.edu	37	chr2	179323290	179323290	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agggacaaagctattgttttCccagcacatacaaccatagc	7	11	0	0			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr2:179323290C>T	uc002umi.3	+	5	959	c.603C>T	c.(601-603)TTC>TTT	p.F201F	DFNB59_uc002umj.3_Silent_p.F201F	NM_001042702	NP_001036167	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	201					sensory perception of sound						0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			CTATTGTTTTCCCAGCACATA	0.343													T	179323290	T	T	179323290	2	4	122	1	0	0	0	0	0	0	0	1	4456	854	30	3		3	DFNB59	2	179323290	Silent	SNP	C	TCGA-12-3653-01A-01D-1495-08	38192621	179323290	63876083	8	8404											
P4HTM	54681	broad.mit.edu	37	chr3	49042445	49042445	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcccataccaagctggtaGccaacgagtctgtacccttc	8	15	1	0			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr3:49042445G>A	uc003cvg.2	+	6	1388	c.1039G>A	c.(1039-1041)GCC>ACC	p.A347T	P4HTM_uc003cvh.2_Missense_Mutation_p.A347T|WDR6_uc011bbx.1_5'Flank|WDR6_uc003cvj.2_5'Flank|WDR6_uc011bby.1_5'Flank|WDR6_uc010hkn.2_5'Flank|WDR6_uc011bbz.1_5'Flank	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	347	Lumenal (Potential).|Fe2OG dioxygenase.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	CAAGCTGGTAGCCAACGAGTC	0.587													A	49042445	A	A	49042445	3	1	122	1	0	0	0	0	1	0	0	0	11360	971	34	3	1061	3	P4HTM	3	49042445	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08		49042445	148979985	9	8405											
ATR	545	broad.mit.edu	37	chr3	142281611	142281611	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaataatacgagtaagaacCattaataaagtgacttcaat	6	6	1	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr3:142281611C>T	uc003eux.3	-	4	755	c.633G>A	c.(631-633)ATG>ATA	p.M211I		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	211					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						GAGTAAGAACCATTAATAAAG	0.318								Other_conserved_DNA_damage_response_genes					T	142281611	T	T	142281611	3	4	122	1	0	0	0	0	1	0	0	0	1204	594	21	3	7477	3	ATR	3	142281611	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	93239166	142281611	55740819	10	8406											
YEATS2	55689	broad.mit.edu	37	chr3	183525871	183525871	+	Frame_Shift_Del	DEL	G	-	-													aggaacgtgtatgcgtccgtGgtggaggacatgatcctgaa							TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr3:183525871delG	uc003fly.2	+	29	4260	c.4065delG	c.(4063-4065)GTGfs	p.V1355fs	uc003fma.1_5'Flank	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1355					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATGCGTCCGTGGTGGAGGACA	0.562													-	183525871	-	-	183525871	7	5	122	1	0	1	0	1	0	0	0	0	17469	1335	47	0	4175	0	YEATS2	3	183525871	Frame_Shift_Del	DEL	G	TCGA-12-3653-01A-01D-1495-08	41244260	183525871	14496559	11	8407											
PCYT1A	5130	broad.mit.edu	37	chr3	195965646	195965646	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaggtggggaagtcttgccGgagaagggccatcggaaaga	17	7	1	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr3:195965646G>A	uc003fwg.2	-	10	1190	c.1017C>T	c.(1015-1017)TCC>TCT	p.S339S	uc003fwf.1_5'Flank|PCYT1A_uc003fwh.2_Silent_p.S339S	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	339	3 X repeats.					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	AAGTCTTGCCGGAGAAGGGCC	0.607													A	195965646	A	A	195965646	2	1	122	1	0	0	0	0	0	0	0	1	11610	1103	39	2		2	PCYT1A	3	195965646	Silent	SNP	G	TCGA-12-3653-01A-01D-1495-08	12439775	195965646	2056784	12	8408											
CDH9	1007	broad.mit.edu	37	chr5	26881547	26881547	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtttcaggcattacatcccGtctaagtttactgtcttctc	6	11	4	0			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr5:26881547G>A	uc003jgs.1	-	12	2237	c.2068C>T	c.(2068-2070)CGG>TGG	p.R690W	CDH9_uc011cnv.1_Missense_Mutation_p.R283W	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	690	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATTACATCCCGTCTAAGTTTA	0.408													A	26881547	A	A	26881547	3	1	122	1	0	0	0	0	1	0	0	0	3117	1144	40	1	305	1	CDH9	5	26881547	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08		26881547	154033713	13	8409											
GDNF	2668	broad.mit.edu	37	chr5	37815950	37815950	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcagctgcatcgcaagagcCgctgcagtacctaaaaatca	8	13	2	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr5:37815950C>T	uc011cpi.1	-	3	639	c.439G>A	c.(439-441)GGC>AGC	p.G147S	GDNF_uc011cpc.1_Missense_Mutation_p.G69S|GDNF_uc011cpd.1_Missense_Mutation_p.G95S|GDNF_uc011cpe.1_Missense_Mutation_p.G121S|GDNF_uc011cpf.1_Missense_Mutation_p.G121S|GDNF_uc011cpg.1_Missense_Mutation_p.G164S|GDNF_uc011cph.1_Missense_Mutation_p.G138S	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	147					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					TCGCAAGAGCCGCTGCAGTAC	0.443													T	37815950	T	T	37815950	3	4	122	1	0	0	0	0	1	0	0	0	6322	652	23	2	199	2	GDNF	5	37815950	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	10934403	37815950	143099310	14	8410											
LNPEP	4012	broad.mit.edu	37	chr5	96341853	96341853	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggatttcctttagtgactgTtcaaaagaaaggaaaggaac	10	5	1	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr5:96341853T>C	uc003kmv.1	+	10	2376	c.1862T>C	c.(1861-1863)GTT>GCT	p.V621A	LNPEP_uc003kmw.1_Missense_Mutation_p.V607A	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	621	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		TTAGTGACTGTTCAAAAGAAA	0.333													C	96341853	C	C	96341853	3	2	122	1	0	0	0	0	1	0	0	0	8864	1725	60	4	1900	4	LNPEP	5	96341853	Missense_Mutation	SNP	T	TCGA-12-3653-01A-01D-1495-08	58525903	96341853	84573407	15	8411											
F13A1	2162	broad.mit.edu	37	chr6	6196068	6196068	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcatcaaattggaagcagaCatggccgtgcttgatggctt	12	8	1	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr6:6196068C>T	uc003mwv.2	-	10	1390	c.1267G>A	c.(1267-1269)GTC>ATC	p.V423I	F13A1_uc011dib.1_Missense_Mutation_p.V360I	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	423					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TGGAAGCAGACATGGCCGTGC	0.498													T	6196068	T	T	6196068	3	4	122	1	0	0	0	0	1	0	0	0	5340	478	17	3	955	3	F13A1	6	6196068	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08		6196068	164918999	16	8412											
PKHD1	5314	broad.mit.edu	37	chr6	51609339	51609339	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gactacttttcctaaatcttTcctgtgaagacagtcaaaaa	5	9	2	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr6:51609339T>C	uc003pah.1	-	60	10276	c.10000A>G	c.(10000-10002)AAA>GAA	p.K3334E	PKHD1_uc010jzn.1_Missense_Mutation_p.K1317E|PKHD1_uc003pai.2_Missense_Mutation_p.K3334E	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3334	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCTAAATCTTTCCTGTGAAGA	0.383													C	51609339	C	C	51609339	3	2	122	1	0	0	0	0	1	0	0	0	11971	1797	62	4	2295	4	PKHD1	6	51609339	Missense_Mutation	SNP	T	TCGA-12-3653-01A-01D-1495-08	45413271	51609339	119505728	17	8413											
COL28A1	340267	broad.mit.edu	37	chr7	7483281	7483281	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgctcccggaagccccgcttCtccctagagaaaatgacact	8	15	1	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr7:7483281C>T	uc003src.1	-	20	1702	c.1585G>A	c.(1585-1587)GAA>AAA	p.E529K	COL28A1_uc011jxe.1_Missense_Mutation_p.E212K|COL28A1_uc003srd.2_Missense_Mutation_p.E84K	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	529	Collagen-like 4.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		AGCCCCGCTTCTCCCTAGAGA	0.517													T	7483281	T	T	7483281	3	4	122	1	0	0	0	0	1	0	0	0	3686	922	32	3	1856	3	COL28A1	7	7483281	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08		7483281	151655382	18	8414											
GRM3	2913	broad.mit.edu	37	chr7	86415877	86415877	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccaacatccgcaagtcctacGacagcgtgatccgagaactg	9	14	0	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr7:86415877G>A	uc003uid.2	+	3	1868	c.769G>A	c.(769-771)GAC>AAC	p.D257N	GRM3_uc010lef.2_Missense_Mutation_p.D255N|GRM3_uc010leg.2_Missense_Mutation_p.D129N|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	257	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CAAGTCCTACGACAGCGTGAT	0.647													A	86415877	A	A	86415877	3	1	122	1	0	0	0	0	1	0	0	0	6798	1058	37	2	775	2	GRM3	7	86415877	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08	78932596	86415877	72722786	19	8415											
ABCB1	5243	broad.mit.edu	37	chr7	87179839	87179839	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	catttctgaattccaaatttCccttaatattatctggtttg	4	8	2	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr7:87179839C>G	uc003uiz.1	-	12	1587	c.1169G>C	c.(1168-1170)GGA>GCA	p.G390A	ABCB1_uc011khc.1_Missense_Mutation_p.G326A	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	390	Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTCCAAATTTCCCTTAATATT	0.313													G	87179839	G	G	87179839	3	3	122	1	0	0	0	0	1	0	0	0	40	855	30	5	2745	5	ABCB1	7	87179839	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	763962	87179839	71958824	20	8416											
NPTX2	4885	broad.mit.edu	37	chr7	98256632	98256632	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccccatcaagcccgggggCgtgctgatccttggacaaga	12	14	1	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr7:98256632C>T	uc003upl.2	+	4	1221	c.1044C>T	c.(1042-1044)GGC>GGT	p.G348G		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	348	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			AGCCCGGGGGCGTGCTGATCC	0.677													T	98256632	T	T	98256632	2	4	122	1	0	0	0	0	0	0	0	1	10603	755	27	1		1	NPTX2	7	98256632	Silent	SNP	C	TCGA-12-3653-01A-01D-1495-08	11076793	98256632	60882031	21	8417											
FOXP2	93986	broad.mit.edu	37	chr7	114282648	114282648	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcattccatagtgaatggacAgtcttcagttctaagtgcaa	8	8	4	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr7:114282648A>G	uc003vhb.2	+	7	1333	c.959A>G	c.(958-960)CAG>CGG	p.Q320R	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.Q345R|FOXP2_uc003vha.2_Missense_Mutation_p.Q228R|FOXP2_uc011kmu.1_Missense_Mutation_p.Q337R|FOXP2_uc011kmv.1_Missense_Mutation_p.Q319R|FOXP2_uc010ljz.1_Missense_Mutation_p.Q228R|FOXP2_uc003vgx.2_Missense_Mutation_p.Q320R|FOXP2_uc003vhd.2_Missense_Mutation_p.Q320R|FOXP2_uc003vhc.2_Missense_Mutation_p.Q345R	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	320					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						GTGAATGGACAGTCTTCAGTT	0.388													G	114282648	G	G	114282648	3	3	122	1	0	0	0	0	1	0	0	0	6027	188	7	4	1115	4	FOXP2	7	114282648	Missense_Mutation	SNP	A	TCGA-12-3653-01A-01D-1495-08	16026016	114282648	44856015	22	8418											
PLXNA4	91584	broad.mit.edu	37	chr7	131887591	131887591	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atggctccacacttgtagagGtgaactgcagaggggaaggg	16	7	0	3			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr7:131887591G>T	uc003vra.3	-	12	2629	c.2400C>A	c.(2398-2400)CAC>CAA	p.H800Q		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	800	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						ACTTGTAGAGGTGAACTGCAG	0.632													T	131887591	T	T	131887591	3	4	122	1	0	0	0	0	1	0	0	0	12122	1252	44	5	3368	5	PLXNA4	7	131887591	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08	17604943	131887591	27251072	23	8419											
TRPV6	55503	broad.mit.edu	37	chr7	142573429	142573429	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgtctggtccaggatctggCgagcctgcaacagaaagaga	14	10	2	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr7:142573429C>T	uc003wbx.1	-	8	1130	c.914G>A	c.(913-915)CGC>CAC	p.R305H	TRPV6_uc003wbw.1_Missense_Mutation_p.R91H|TRPV6_uc010lou.1_Missense_Mutation_p.R176H	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	305	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CAGGATCTGGCGAGCCTGCAA	0.607													T	142573429	T	T	142573429	3	4	122	1	0	0	0	0	1	0	0	0	16597	768	27	1	1295	1	TRPV6	7	142573429	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	10685838	142573429	16565234	24	8420											
ZYX	7791	broad.mit.edu	37	chr7	143080299	143080299	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggggcaccccgaagctcttTctgctggcacaggctcccct	11	16	2	0			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr7:143080299T>C	uc003wcw.2	+	5	1062	c.907T>C	c.(907-909)TCT>CCT	p.S303P	ZYX_uc011ktd.1_Missense_Mutation_p.S146P|ZYX_uc003wcx.2_Missense_Mutation_p.S303P|ZYX_uc011kte.1_Missense_Mutation_p.S272P|ZYX_uc011ktf.1_Missense_Mutation_p.S146P	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	303					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					CGAAGCTCTTTCTGCTGGCAC	0.597													C	143080299	C	C	143080299	3	2	122	1	0	0	0	0	1	0	0	0	18251	1783	62	4	921	4	ZYX	7	143080299	Missense_Mutation	SNP	T	TCGA-12-3653-01A-01D-1495-08	506870	143080299	16058364	25	8421											
ZFAT	57623	broad.mit.edu	37	chr8	135612748	135612748	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgagtagtcacagccatcGgtgggacacttcagcaagat	12	9	2	2	rs144002982	by1000genomes	TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr8:135612748G>A	uc003yup.2	-	7	2581	c.2406C>T	c.(2404-2406)ACC>ACT	p.T802T	ZFAT_uc003yun.2_Silent_p.T790T|ZFAT_uc003yuo.2_Silent_p.T790T|ZFAT_uc010meh.2_Silent_p.T790T|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.T790T|ZFAT_uc010mej.2_Silent_p.T740T|ZFAT_uc003yur.2_Silent_p.T790T|ZFATAS_uc003yus.1_RNA	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	802	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CACAGCCATCGGTGGGACACT	0.448													A	135612748	A	A	135612748	2	1	122	1	0	0	0	0	0	0	0	1	17629	1103	39	2		2	ZFAT	8	135612748	Silent	SNP	G	TCGA-12-3653-01A-01D-1495-08		135612748	10751274	26	8422											
C9orf102	375748	broad.mit.edu	37	chr9	98683552	98683552	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atacttcaatcttctgagccTtgtacctgtaggagtggcca	9	10	3	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr9:98683552T>G	uc004avt.3	+	7	1675	c.1287T>G	c.(1285-1287)CCT>CCG	p.P429P	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Silent_p.P131P|C9orf102_uc010mry.1_Silent_p.P131P|C9orf102_uc010mrz.2_Silent_p.P240P|C9orf102_uc004avu.2_5'Flank	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	429					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				CTTCTGAGCCTTGTACCTGTA	0.363													G	98683552	G	G	98683552	2	3	122	1	0	0	0	0	0	0	0	1	2445	1596	56	5		5	C9orf102	9	98683552	Silent	SNP	T	TCGA-12-3653-01A-01D-1495-08		98683552	42529879	27	8423											
KIF20B	9585	broad.mit.edu	37	chr10	91498196	91498196	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcatcttaaagctagaaagaAatttgaaggaatttcaagaa	7	4	3	4			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr10:91498196A>G	uc001kgs.1	+	20	3670	c.3598A>G	c.(3598-3600)AAT>GAT	p.N1200D	KIF20B_uc001kgr.1_Missense_Mutation_p.N1160D|KIF20B_uc001kgt.1_Missense_Mutation_p.N411D|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1200					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						GCTAGAAAGAAATTTGAAGGA	0.318													G	91498196	G	G	91498196	3	3	122	1	0	0	0	0	1	0	0	0	8287	14	1	4	3552	4	KIF20B	10	91498196	Missense_Mutation	SNP	A	TCGA-12-3653-01A-01D-1495-08		91498196	44036551	28	8424											
ZNF518A	9849	broad.mit.edu	37	chr10	97916083	97916083	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttttttggttaaatcatgCcatctgaacagaaacagtta	6	7	2	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr10:97916083C>T	uc001klp.2	+	6	861	c.4C>T	c.(4-6)CCA>TCA	p.P2S	ZNF518A_uc001klo.1_Intron|ZNF518A_uc001klq.2_Missense_Mutation_p.P2S|ZNF518A_uc001klr.2_Missense_Mutation_p.P2S	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TTAAATCATGCCATCTGAACA	0.308													T	97916083	T	T	97916083	3	4	122	1	0	0	0	0	1	0	0	0	17959	739	26	3	6	3	ZNF518A	10	97916083	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	6417887	97916083	37618664	29	8425											
HEPHL1	341208	broad.mit.edu	37	chr11	93826783	93826783	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gatcaaagcccgaccaccacGagaggagcacttagaactcc	9	14	1	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr11:93826783G>A	uc001pep.2	+	13	2568	c.2411G>A	c.(2410-2412)CGA>CAA	p.R804Q	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	804	Plastocyanin-like 5.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CGACCACCACGAGAGGAGCAC	0.483													A	93826783	A	A	93826783	3	1	122	1	0	0	0	0	1	0	0	0	7055	1058	37	2	2461	2	HEPHL1	11	93826783	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08		93826783	41179733	30	8426											
PGR	5241	broad.mit.edu	37	chr11	100920711	100920711	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaggaactcttcttggctaaCttgaagcttgacaaactcct	8	10	2	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr11:100920711C>A	uc001pgh.2	-	6	3180	c.2437G>T	c.(2437-2439)GTT>TTT	p.V813F	PGR_uc001pgg.2_Missense_Mutation_p.V194F|PGR_uc001pgi.2_Missense_Mutation_p.V711F|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	813	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	TCTTGGCTAACTTGAAGCTTG	0.368													A	100920711	A	A	100920711	3	1	122	1	0	0	0	0	1	0	0	0	11805	565	20	5	376	5	PGR	11	100920711	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	7093928	100920711	34085805	31	8427											
NTF3	4908	broad.mit.edu	37	chr12	5603770	5603770	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtgggcagccccgtggtggcGaacagaacatcacggcggaa	16	11	1	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr12:5603770G>A	uc001qnl.3	+	1	473	c.390G>A	c.(388-390)GCG>GCA	p.A130A	NTF3_uc001qnk.3_Silent_p.A143A	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	130					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						CCGTGGTGGCGAACAGAACAT	0.602													A	5603770	A	A	5603770	2	1	122	1	0	0	0	0	0	0	0	1	10696	1045	37	2		2	NTF3	12	5603770	Silent	SNP	G	TCGA-12-3653-01A-01D-1495-08		5603770	128248125	32	8428											
C1S	716	broad.mit.edu	37	chr12	7177641	7177641	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgctgttcgcctcaaggcgGcaaggttacctgtagctcct	12	12	1	0			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr12:7177641G>A	uc001qsj.2	+	15	2472	c.1753G>A	c.(1753-1755)GCA>ACA	p.A585T	C1S_uc001qsk.2_Missense_Mutation_p.A585T|C1S_uc001qsl.2_Missense_Mutation_p.A585T|C1S_uc009zfr.2_Missense_Mutation_p.A418T|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	585	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	CCTCAAGGCGGCAAGGTTACC	0.512													A	7177641	A	A	7177641	3	1	122	1	0	0	0	0	1	0	0	0	1974	1203	42	3	1795	3	C1S	12	7177641	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08	1573871	7177641	126674254	33	8429											
SPPL2A	84888	broad.mit.edu	37	chr15	51041869	51041869	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttggaagagctgtccaataAgggttataaagcatgcagta	11	6	0	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr15:51041869A>G	uc001zyv.2	-	2	321	c.141T>C	c.(139-141)CCT>CCC	p.P47P		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	47	Cytoplasmic (Potential).					integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		CTGTCCAATAAGGGTTATAAA	0.363													G	51041869	G	G	51041869	2	3	122	1	0	0	0	0	0	0	0	1	15087	59	3	4		4	SPPL2A	15	51041869	Silent	SNP	A	TCGA-12-3653-01A-01D-1495-08		51041869	51489523	34	8430											
ACAP1	9744	broad.mit.edu	37	chr17	7250193	7250193	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtcagtgctgtgcagagcagCattgcttctgccttcagtca	11	11	4	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr17:7250193C>A	uc002ggd.2	+	13	1280	c.1074C>A	c.(1072-1074)AGC>AGA	p.S358R		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	358	PH.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						TGCAGAGCAGCATTGCTTCTG	0.637													A	7250193	A	A	7250193	3	1	122	1	0	0	0	0	1	0	0	0	118	709	25	5	1124	5	ACAP1	17	7250193	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08		7250193	73945017	35	8431											
TNS4	84951	broad.mit.edu	37	chr17	38635988	38635988	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaagtggaccacggtgggCgtggggaggatgtccctctc	17	9	1	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr17:38635988C>T	uc010cxb.2	-	10	2012	c.1848G>A	c.(1846-1848)ACG>ACA	p.T616T	TNS4_uc002huu.3_Intron	NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	616	Phosphatase tensin-type.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			CCACGGTGGGCGTGGGGAGGA	0.617													T	38635988	T	T	38635988	2	4	122	1	0	0	0	0	0	0	0	1	16342	755	27	1		1	TNS4	17	38635988	Silent	SNP	C	TCGA-12-3653-01A-01D-1495-08	31385795	38635988	42559222	36	8432											
KRTAP4-11	653240	broad.mit.edu	37	chr17	39274446	39274446	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggacacacagcagctggggCgacagtaggtggtcctgcag	16	10	0	0			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr17:39274446C>T	uc002hvz.2	-	1	161	c.122G>A	c.(121-123)CGC>CAC	p.R41H		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	41	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGCTGGGGCGACAGTAGGT	0.667													T	39274446	T	T	39274446	3	4	122	1	0	0	0	0	1	0	0	0	8549	768	27	1	469	1	KRTAP4-11	17	39274446	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	638458	39274446	41920764	37	8433											
ARL4D	379	broad.mit.edu	37	chr17	41477126	41477126	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaccacttgactgagatggCgcccactgcctcctccttct	8	16	1	2			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr17:41477126C>T	uc002idt.2	+	2	207	c.26C>T	c.(25-27)GCG>GTG	p.A9V		NM_001661	NP_001652	P49703	ARL4D_HUMAN	ADP-ribosylation factor-like 4D	9					protein secretion|small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)	1		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.155)		ACTGAGATGGCGCCCACTGCC	0.572													T	41477126	T	T	41477126	3	4	122	1	0	0	0	0	1	0	0	0	938	768	27	1	28	1	ARL4D	17	41477126	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	2202680	41477126	39718084	38	8434											
TUBB4	10382	broad.mit.edu	37	chr19	6495656	6495656	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgggtgagctcgggcaccGtcagggcccggtactgctgg	18	12	1	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr19:6495656G>A	uc002mfg.1	-	4	961	c.854C>T	c.(853-855)ACG>ATG	p.T285M	TUBB4_uc002mff.1_Missense_Mutation_p.T213M|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	285					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		CTCGGGCACCGTCAGGGCCCG	0.672													A	6495656	A	A	6495656	3	1	122	1	0	0	0	0	1	0	0	0	16755	1145	40	1	484	1	TUBB4	19	6495656	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08		6495656	52633327	39	8435											
VAV1	7409	broad.mit.edu	37	chr19	6843162	6843162	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttagggccctcctcaggaccTgtctgttcatctctggtgag	11	12	4	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr19:6843162T>C	uc002mfu.1	+	22	2094	c.1997T>C	c.(1996-1998)CTG>CCG	p.L666P	VAV1_uc010xjh.1_Missense_Mutation_p.L634P|VAV1_uc010dva.1_Missense_Mutation_p.L644P|VAV1_uc002mfv.1_Missense_Mutation_p.L611P	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	666					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CCTCAGGACCTGTCTGTTCAT	0.468													C	6843162	C	C	6843162	3	2	122	1	0	0	0	0	1	0	0	0	17128	1580	55	4	2083	4	VAV1	19	6843162	Missense_Mutation	SNP	T	TCGA-12-3653-01A-01D-1495-08	347506	6843162	52285821	40	8436											
ZNF701	55762	broad.mit.edu	37	chr19	53086225	53086228	+	Frame_Shift_Del	DEL	AAGG	-	-													acaagtgtaatgaatgtggcAaggtttttaatcaacaatca							TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr19:53086225_53086228delAAGG	uc002pzs.1	+	4	1040_1043	c.913_916delAAGG	c.(913-918)AAGGTTfs	p.K305fs	ZNF701_uc010ydn.1_Frame_Shift_Del_p.K371fs	NM_018260	NP_060730	Q9NV72	ZN701_HUMAN	zinc finger protein 701	305_306	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		TGAATGTGGCAAGGTTTTTAATCA	0.387													-	53086228	-	-	53086225	7	5	122	1	0	1	0	1	0	0	0	0	18102	131	5	0	1125	0	ZNF701	19	53086225	Frame_Shift_Del	DEL	AAGG	TCGA-12-3653-01A-01D-1495-08	46243063	53086225	6042758	41	8437											
ITSN1	6453	broad.mit.edu	37	chr21	35206635	35206635	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgggaaaaagcgccagataGgctggttcccagctaattat	12	8	0	1			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr21:35206635G>A	uc002yta.1	+	28	3644	c.3376G>A	c.(3376-3378)GGC>AGC	p.G1126S	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.G1050S|ITSN1_uc010gmg.2_Missense_Mutation_p.G1013S|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.G1126S|ITSN1_uc010gmi.2_Missense_Mutation_p.G1089S|ITSN1_uc010gmj.2_Missense_Mutation_p.G1005S|ITSN1_uc002ysy.2_Missense_Mutation_p.G1121S|ITSN1_uc002ysx.2_Missense_Mutation_p.G1084S|ITSN1_uc002ytb.1_Missense_Mutation_p.G1121S|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.G1018S|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.G1121S|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.G989S|ITSN1_uc002yti.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1126	SH3 4.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						GCGCCAGATAGGCTGGTTCCC	0.423													A	35206635	A	A	35206635	3	1	122	1	0	0	0	0	1	0	0	0	7926	1000	35	3	3482	3	ITSN1	21	35206635	Missense_Mutation	SNP	G	TCGA-12-3653-01A-01D-1495-08		35206635	12923260	42	8438											
KRTAP10-3	386682	broad.mit.edu	37	chr21	45978262	45978262	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagacaggcttgcagcagaCgggcacacagcagactggct	14	12	0	3			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chr21:45978262C>T	uc002zfj.1	-	1	382	c.337G>A	c.(337-339)GTC>ATC	p.V113I	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198696	NP_941969	P60369	KR103_HUMAN	keratin associated protein 10-3	113	9.|18 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						ttgcagcagacgggcacacag	0.189													T	45978262	T	T	45978262	3	4	122	1	0	0	0	0	1	0	0	0	8510	536	19	1	332	1	KRTAP10-3	21	45978262	Missense_Mutation	SNP	C	TCGA-12-3653-01A-01D-1495-08	10771627	45978262	2151633	43	8439											
XK	7504	broad.mit.edu	37	chrX	37587132	37587133	+	Frame_Shift_Ins	INS	-	C	C													ttcttcagtttcttcttgtaINScccctggatcctcttctggt							TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chrX:37587132_37587133insC	uc004ddq.2	+	3	834_835	c.752_753insC	c.(751-753)TACfs	p.Y251fs		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	251	Helical; (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				TTCTTCTTGTACCCCTGGATCC	0.485													C	37587133	C	C	37587132	7	5	122	1	0	1	1	0	0	0	0	0	17428	391	14	0	762	0	XK	23	37587132	Frame_Shift_Ins	INS	-	TCGA-12-3653-01A-01D-1495-08		37587132	117683428	44	8440											
SMARCA1	6594	broad.mit.edu	37	chrX	128621040	128621040	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccctcaaatttgtataaactTtgttcaatgtccattctaaa	3	9	3	0			TCGA-12-3653-01A-01D-1495-08	TCGA-12-3653-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fdc52d48-828e-481f-ba1c-0264f1da38a5	6d1c37a3-4c31-404f-98b5-bc81876f4080	g.chrX:128621040T>G	uc004eun.3	-	17	2285	c.2172A>C	c.(2170-2172)CAA>CAC	p.Q724H	SMARCA1_uc004eup.3_Missense_Mutation_p.Q712H|SMARCA1_uc011muk.1_Missense_Mutation_p.Q724H|SMARCA1_uc011mul.1_Missense_Mutation_p.Q712H	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	724					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						TGTATAAACTTTGTTCAATGT	0.348													G	128621040	G	G	128621040	3	3	122	1	0	0	0	0	1	0	0	0	14768	1838	64	5	1024	5	SMARCA1	23	128621040	Missense_Mutation	SNP	T	TCGA-12-3653-01A-01D-1495-08	91033908	128621040	26649520	45	8441											
NECAP2	55707	broad.mit.edu	37	chr1	16778338	16778338	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctcttccctctttagaacatGaagaagaaggaaggagcagc	10	9	2	4			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr1:16778338G>A	uc001ayo.2	+	6	585	c.495G>A	c.(493-495)ATG>ATA	p.M165I	NECAP2_uc001ayp.3_RNA|NECAP2_uc010ocd.1_Missense_Mutation_p.M139I|NECAP2_uc001ayq.2_Missense_Mutation_p.M165I	NM_018090	NP_060560	Q9NVZ3	NECP2_HUMAN	NECAP endocytosis associated 2 isoform 1	165					endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane					0		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TTTAGAACATGAAGAAGAAGG	0.602													A	16778338	A	A	16778338	3	1	123	1	0	0	0	0	1	0	0	0	10308	1290	45	3	517	3	NECAP2	1	16778338	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08		16778338	232472283	1	8442											
HNRNPR	10236	broad.mit.edu	37	chr1	23648083	23648083	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tattcttcggaatggatccaAcaaaaagtctgttgtttgcc	8	8	2	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr1:23648083A>C	uc001bgr.3	-	7	908	c.749T>G	c.(748-750)GTT>GGT	p.V250G	HNRNPR_uc001bgp.3_Missense_Mutation_p.V250G|HNRNPR_uc009vqk.2_Missense_Mutation_p.V149G|HNRNPR_uc001bgs.3_Missense_Mutation_p.V149G|HNRNPR_uc010odw.1_Missense_Mutation_p.V212G|HNRNPR_uc010odx.1_Missense_Mutation_p.V90G|HNRNPR_uc009vql.2_Missense_Mutation_p.V111G	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	250	RRM 2.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		AATGGATCCAACAAAAAGTCT	0.363													C	23648083	C	C	23648083	3	2	123	1	0	0	0	0	1	0	0	0	7272	43	2	5	1181	5	HNRNPR	1	23648083	Missense_Mutation	SNP	A	TCGA-12-5295-01A-01D-1486-08	6869745	23648083	225602538	2	8443											
PUM1	9698	broad.mit.edu	37	chr1	31406150	31406150	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttggccagaatgtgcttgcCataggtgtacttacgaagag	12	8	0	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr1:31406150C>T	uc001bsi.1	-	22	3582	c.3469G>A	c.(3469-3471)GGC>AGC	p.G1157S	PUM1_uc001bsf.1_Missense_Mutation_p.G825S|PUM1_uc001bsg.1_Missense_Mutation_p.G891S|PUM1_uc001bsh.1_Missense_Mutation_p.G1159S|PUM1_uc001bsj.1_Missense_Mutation_p.G1133S|PUM1_uc010oga.1_Missense_Mutation_p.G1015S|PUM1_uc001bsk.1_Missense_Mutation_p.G1195S|PUM1_uc010ogb.1_Missense_Mutation_p.G1098S	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	1157	PUM-HD.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		ATGTGCTTGCCATAGGTGTAC	0.537													T	31406150	T	T	31406150	3	4	123	1	0	0	0	0	1	0	0	0	12825	594	21	3	95	3	PUM1	1	31406150	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	7758067	31406150	217844471	3	8444											
KCNQ4	9132	broad.mit.edu	37	chr1	41285881	41285881	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgaaggtccaggagcagcaCcggcagaagcacttcgagaa	13	11	0	3			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr1:41285881C>T	uc001cgh.1	+	7	1072	c.990C>T	c.(988-990)CAC>CAT	p.H330H	KCNQ4_uc001cgi.1_Silent_p.H330H	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	330	Cytoplasmic.				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			AGGAGCAGCACCGGCAGAAGC	0.617													T	41285881	T	T	41285881	2	4	123	1	0	0	0	0	0	0	0	1	8085	506	18	3		3	KCNQ4	1	41285881	Silent	SNP	C	TCGA-12-5295-01A-01D-1486-08	9879731	41285881	207964740	4	8445											
AMPD1	270	broad.mit.edu	37	chr1	115215817	115215817	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gataggccatgcggatttggGctacatttgtcctccggata	12	9	0	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr1:115215817G>T	uc001efe.1	-	16	2246	c.2162C>A	c.(2161-2163)GCC>GAC	p.A721D	DENND2C_uc001eez.2_5'Flank|AMPD1_uc001eff.1_Missense_Mutation_p.A717D	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	721					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	GCGGATTTGGGCTACATTTGT	0.398													T	115215817	T	T	115215817	3	4	123	1	0	0	0	0	1	0	0	0	585	1203	42	5	85	5	AMPD1	1	115215817	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	73929936	115215817	134034804	5	8446											
PDE4DIP	9659	broad.mit.edu	37	chr1	144882550	144882550	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggtgttggtgcttcccagGggaaccaaccagttctgtgt	13	9	1	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr1:144882550G>A	uc001elw.3	-	24	3760	c.3469C>T	c.(3469-3471)CCT>TCT	p.P1157S	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.P164S	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1157					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGCTTCCCAGGGGAACCAACC	0.522			T	PDGFRB	MPD								A	144882550	A	A	144882550	3	1	123	1	0	0	0	0	1	0	0	0	11643	1232	43	3	3655	3	PDE4DIP	1	144882550	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	29666733	144882550	104368071	6	8447											
IQGAP3	128239	broad.mit.edu	37	chr1	156532968	156532968	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctccatcttggcctgggcCagcatctcttggtagacggc	11	13	3	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr1:156532968C>T	uc001fpf.2	-	8	831	c.756G>A	c.(754-756)CTG>CTA	p.L252L	IQGAP3_uc009wsb.1_Silent_p.L209L	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	252					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGCCTGGGCCAGCATCTCTT	0.572													T	156532968	T	T	156532968	2	4	123	1	0	0	0	0	0	0	0	1	7816	581	21	3		3	IQGAP3	1	156532968	Silent	SNP	C	TCGA-12-5295-01A-01D-1486-08	11650418	156532968	92717653	7	8448											
KCNT2	343450	broad.mit.edu	37	chr1	196227421	196227421	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgtagaggttcagtcgctgCtgggttattttttcagctgt	12	7	2	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr1:196227421C>A	uc001gtd.1	-	26	3174	c.3114G>T	c.(3112-3114)CAG>CAT	p.Q1038H	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.Q971H|KCNT2_uc001gtf.1_Missense_Mutation_p.Q1014H|KCNT2_uc001gtg.1_RNA|KCNT2_uc001gth.1_Missense_Mutation_p.Q542H	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1038	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TCAGTCGCTGCTGGGTTATTT	0.468													A	196227421	A	A	196227421	3	1	123	1	0	0	0	0	1	0	0	0	8092	796	28	5	305	5	KCNT2	1	196227421	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	39694453	196227421	53023200	8	8449											
MXD1	4084	broad.mit.edu	37	chr2	70164461	70164461	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcagctggagaagctgggcaTtgagaggatccggatggaca	17	7	0	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr2:70164461T>C	uc002sfy.2	+	5	673	c.413T>C	c.(412-414)ATT>ACT	p.I138T	MXD1_uc010yqp.1_Missense_Mutation_p.I138T|MXD1_uc010yqq.1_Missense_Mutation_p.I75T|MXD1_uc010yqr.1_RNA|MXD1_uc010yqs.1_Missense_Mutation_p.I128T	NM_002357	NP_002348	Q05195	MAD1_HUMAN	MAX dimerization protein 1	138					cell proliferation|multicellular organismal development	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						AAGCTGGGCATTGAGAGGATC	0.577													C	70164461	C	C	70164461	3	2	123	1	0	0	0	0	1	0	0	0	9999	1493	52	4	431	4	MXD1	2	70164461	Missense_Mutation	SNP	T	TCGA-12-5295-01A-01D-1486-08		70164461	173034912	9	8450											
C2orf51	200523	broad.mit.edu	37	chr2	88828848	88828848	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccagagtgctgactttccGtgcctcgtggatcccaaaca	9	14	0	2	rs148580273		TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr2:88828848G>A	uc002stb.1	+	4	541	c.399G>A	c.(397-399)CCG>CCA	p.P133P		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	133						nucleus				skin(1)	1						CTGACTTTCCGTGCCTCGTGG	0.572													A	88828848	A	A	88828848	2	1	123	1	0	0	0	0	0	0	0	1	2173	1132	40	1		1	C2orf51	2	88828848	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08	18664387	88828848	154370525	10	8451											
NMS	129521	broad.mit.edu	37	chr2	101089991	101089991	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagtgggcacctctttctcGccaacctaaggtaaaaaaat	7	11	3	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr2:101089991G>A	uc002tan.1	+	3	180	c.173G>A	c.(172-174)CGC>CAC	p.R58H		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	58					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						CCTCTTTCTCGCCAACCTAAG	0.259													A	101089991	A	A	101089991	3	1	123	1	0	0	0	0	1	0	0	0	10502	1087	38	1	183	1	NMS	2	101089991	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	12261143	101089991	142109382	11	8452											
TTN	7273	broad.mit.edu	37	chr2	179457532	179457532	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttttactaggactggctccgGaacatgagctggatctgatt	11	8	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr2:179457532G>A	uc010zfg.1	-	249	51834	c.51610C>T	c.(51610-51612)CCG>TCG	p.P17204S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P10899S|TTN_uc010zfi.1_Missense_Mutation_p.P10832S|TTN_uc010zfj.1_Missense_Mutation_p.P10707S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18131							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTGGCTCCGGAACATGAGCT	0.408													A	179457532	A	A	179457532	3	1	123	1	0	0	0	0	1	0	0	0	16732	1174	41	3	48917	3	TTN	2	179457532	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	78367541	179457532	63741841	12	8453											
FN1	2335	broad.mit.edu	37	chr2	216288171	216288171	+	Frame_Shift_Del	DEL	G	-	-													tgccctcagaagtgcaatcaGtgtaattgtggttgttgtat							TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr2:216288171delG	uc002vfa.2	-	9	1561	c.1295delC	c.(1294-1296)ACTfs	p.T432fs	FN1_uc002vfb.2_Frame_Shift_Del_p.T432fs|FN1_uc002vfc.2_Frame_Shift_Del_p.T432fs|FN1_uc002vfd.2_Frame_Shift_Del_p.T432fs|FN1_uc002vfe.2_Frame_Shift_Del_p.T432fs|FN1_uc002vff.2_Frame_Shift_Del_p.T432fs|FN1_uc002vfg.2_Frame_Shift_Del_p.T432fs|FN1_uc002vfh.2_Frame_Shift_Del_p.T432fs|FN1_uc002vfi.2_Frame_Shift_Del_p.T432fs|FN1_uc002vfj.2_Frame_Shift_Del_p.T432fs|FN1_uc002vfl.2_Frame_Shift_Del_p.T432fs	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	432	Fibronectin type-II 2.|Collagen-binding.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTGCAATCAGTGTAATTGTG	0.488													-	216288171	-	-	216288171	7	5	123	1	0	1	0	1	0	0	0	0	5962	1029	36	0	6323	0	FN1	2	216288171	Frame_Shift_Del	DEL	G	TCGA-12-5295-01A-01D-1486-08	36830639	216288171	26911202	13	8454											
ZFAND2B	130617	broad.mit.edu	37	chr2	220073015	220073015	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagcacaagctgtggcttctAcaagcactgtccccagccca	9	15	1	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr2:220073015A>G	uc002vka.2	+	5	644	c.472A>G	c.(472-474)ACA>GCA	p.T158A	ZFAND2B_uc010zkt.1_Missense_Mutation_p.T158A|ZFAND2B_uc010fwd.1_Missense_Mutation_p.T158A|ZFAND2B_uc002vjy.1_Missense_Mutation_p.T158A|ZFAND2B_uc002vjz.1_Missense_Mutation_p.T158A|ZFAND2B_uc002vkb.1_Missense_Mutation_p.T49A	NM_138802	NP_620157	Q8WV99	ZFN2B_HUMAN	zinc finger, AN1-type domain 2B	158						endoplasmic reticulum	protein binding|zinc ion binding				0		Renal(207;0.0915)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTGGCTTCTACAAGCACTGT	0.552													G	220073015	G	G	220073015	3	3	123	1	0	0	0	0	1	0	0	0	17625	391	14	4	490	4	ZFAND2B	2	220073015	Missense_Mutation	SNP	A	TCGA-12-5295-01A-01D-1486-08	3784844	220073015	23126358	14	8455											
SP110	3431	broad.mit.edu	37	chr2	231042927	231042927	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgcctcaccacaggtcacggGgagcttagaacagtgaaaat	11	11	2	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr2:231042927G>T	uc002vqh.3	-	13	1633	c.1393C>A	c.(1393-1395)CCC>ACC	p.P465T	SP110_uc002vqg.3_Missense_Mutation_p.P465T|SP110_uc002vqi.3_Missense_Mutation_p.P465T|SP110_uc010fxk.2_Missense_Mutation_p.P463T|SP110_uc010fxj.2_Missense_Mutation_p.P108T	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	465	SAND.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		CAGGTCACGGGGAGCTTAGAA	0.413													T	231042927	T	T	231042927	3	4	123	1	0	0	0	0	1	0	0	0	14961	1232	43	5	840	5	SP110	2	231042927	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	10969912	231042927	12156446	15	8456											
RYBP	23429	broad.mit.edu	37	chr3	72427619	72427619	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgtctgtgctctctgaccCcgagctgctctggttctgct	10	14	4	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr3:72427619C>T	uc003dpe.2	-	4	691	c.574G>A	c.(574-576)GGG>AGG	p.G192R		NM_012234	NP_036366	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	202	Interaction with E4TF1B.|Ser-rich.				apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding				0		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		CTCTCTGACCCCGAGCTGCTC	0.512													T	72427619	T	T	72427619	3	4	123	1	0	0	0	0	1	0	0	0	13766	623	22	3	86	3	RYBP	3	72427619	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08		72427619	125594811	16	8457											
NUDT16	131870	broad.mit.edu	37	chr3	131101062	131101062	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcccacgtcgggtcagggcCacgcgttgtggcccacttct	12	16	2	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr3:131101062C>T	uc003eof.2	+	2	253	c.212C>T	c.(211-213)CCA>CTA	p.P71L	uc003eoc.1_5'Flank|NUDT16_uc011bln.1_Missense_Mutation_p.P58L|NUDT16_uc003eog.1_Missense_Mutation_p.P71L	NM_152395	NP_689608	Q96DE0	NUD16_HUMAN	nudix-type motif 16	104	Nudix hydrolase.					nucleolus|nucleoplasm	hydrolase activity|metal ion binding|RNA binding				0						GGGTCAGGGCCACGCGTTGTG	0.692													T	131101062	T	T	131101062	3	4	123	1	0	0	0	0	1	0	0	0	10732	594	21	3	317	3	NUDT16	3	131101062	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	58673443	131101062	66921368	17	8458											
SPSB4	92369	broad.mit.edu	37	chr3	140866045	140866045	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgctcggccctgggccgccaGcgcctgcaggacatcagctc	13	18	1	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr3:140866045G>A	uc003ett.2	+	3	1010	c.756G>A	c.(754-756)CAG>CAA	p.Q252Q	SPSB4_uc010hum.2_3'UTR	NM_080862	NP_543138	Q96A44	SPSB4_HUMAN	splA/ryanodine receptor domain and SOCS box	252	SOCS box.				intracellular signal transduction	cytoplasm	protein binding				0						TGGGCCGCCAGCGCCTGCAGG	0.617													A	140866045	A	A	140866045	2	1	123	1	0	0	0	0	0	0	0	1	15114	962	34	3		3	SPSB4	3	140866045	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08	9764983	140866045	57156385	18	8459											
DRD5	1816	broad.mit.edu	37	chr4	9783859	9783859	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcagccatcgtgcggagccGccacctgcgcgccaacatga	12	17	0	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr4:9783859G>A	uc003gmb.3	+	1	602	c.206G>A	c.(205-207)CGC>CAC	p.R69H		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	69	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GTGCGGAGCCGCCACCTGCGC	0.647													A	9783859	A	A	9783859	3	1	123	1	0	0	0	0	1	0	0	0	4760	1087	38	1	208	1	DRD5	4	9783859	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08		9783859	181370417	19	8460											
FGFBP1	9982	broad.mit.edu	37	chr4	15938124	15938124	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttctgcttaatctgggtgttGcccagagtgtccttttgttc	10	9	2	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr4:15938124G>T	uc003gom.2	-	2	250	c.132C>A	c.(130-132)GGC>GGA	p.G44G		NM_005130	NP_005121	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	44					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding				0						TCTGGGTGTTGCCCAGAGTGT	0.517													T	15938124	T	T	15938124	2	4	123	1	0	0	0	0	0	0	0	1	5860	1306	46	5		5	FGFBP1	4	15938124	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08	6154265	15938124	175216152	20	8461											
RFC1	5981	broad.mit.edu	37	chr4	39306546	39306546	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tccacgtagctgtatcccaaCtcctaatcaaaatattggaa	5	11	1	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr4:39306546C>A	uc003gty.1	-	15	2135	c.2001G>T	c.(1999-2001)GAG>GAT	p.E667D	RFC1_uc003gtx.1_Missense_Mutation_p.E666D	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	667					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						TGTATCCCAACTCCTAATCAA	0.433													A	39306546	A	A	39306546	3	1	123	1	0	0	0	0	1	0	0	0	13244	564	20	5	1489	5	RFC1	4	39306546	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	23368422	39306546	151847730	21	8462											
LIMCH1	22998	broad.mit.edu	37	chr4	41621353	41621353	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgaacaaaagcaatcagacGgcctacgtccccgcgcctct	8	17	2	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr4:41621353G>A	uc003gvu.3	+	8	885	c.831G>A	c.(829-831)ACG>ACA	p.T277T	LIMCH1_uc003gvt.1_Silent_p.T118T|LIMCH1_uc003gvv.3_Silent_p.T277T|LIMCH1_uc003gvw.3_Silent_p.T277T|LIMCH1_uc003gvx.3_Silent_p.T277T|LIMCH1_uc003gwe.3_Silent_p.T277T|LIMCH1_uc003gvy.3_Silent_p.T118T|LIMCH1_uc003gwa.3_Silent_p.T118T|LIMCH1_uc003gvz.3_Silent_p.T118T|LIMCH1_uc011byu.1_Silent_p.T123T|LIMCH1_uc003gwc.3_Silent_p.T123T|LIMCH1_uc003gwd.3_Silent_p.T123T|LIMCH1_uc011byv.1_Silent_p.T28T|LIMCH1_uc003gwb.1_Silent_p.T125T	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	277					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						GCAATCAGACGGCCTACGTCC	0.567													A	41621353	A	A	41621353	2	1	123	1	0	0	0	0	0	0	0	1	8797	1103	39	2		2	LIMCH1	4	41621353	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08	2314807	41621353	149532923	22	8463											
UGT2B11	10720	broad.mit.edu	37	chr4	70080048	70080048	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcataactttcttatttgaAactacatctttacagaagtt	3	7	3	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr4:70080048A>C	uc003heh.2	-	1	402	c.393T>G	c.(391-393)GTT>GTG	p.V131V	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	131					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						TCTTATTTGAAACTACATCTT	0.343													C	70080048	C	C	70080048	2	2	123	1	0	0	0	0	0	0	0	1	16954	1	1	5		5	UGT2B11	4	70080048	Silent	SNP	A	TCGA-12-5295-01A-01D-1486-08	28458695	70080048	121074228	23	8464											
FRAS1	80144	broad.mit.edu	37	chr4	79295398	79295398	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcagatcatgcaaagcacaaAtgcacaggtaacttggagac	10	9	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr4:79295398A>T	uc003hlb.2	+	25	3584	c.3144A>T	c.(3142-3144)AAA>AAT	p.K1048N	FRAS1_uc003hkw.2_Missense_Mutation_p.K1048N	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1047	FU 14.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CAAAGCACAAATGCACAGGTA	0.473													T	79295398	T	T	79295398	3	4	123	1	0	0	0	0	1	0	0	0	6042	98	4	5	3242	5	FRAS1	4	79295398	Missense_Mutation	SNP	A	TCGA-12-5295-01A-01D-1486-08	9215350	79295398	111858878	24	8465											
NDST4	64579	broad.mit.edu	37	chr4	115767016	115767016	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccctgtctgaggggtcaatgAggatggtgatgatcttggct	15	7	3	4			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr4:115767016A>G	uc003ibu.2	-	10	2757	c.2078T>C	c.(2077-2079)CTC>CCC	p.L693P	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	693	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GGGGTCAATGAGGATGGTGAT	0.428													G	115767016	G	G	115767016	3	3	123	1	0	0	0	0	1	0	0	0	10258	304	11	4	560	4	NDST4	4	115767016	Missense_Mutation	SNP	A	TCGA-12-5295-01A-01D-1486-08	36471618	115767016	75387260	25	8466											
ODZ3	55714	broad.mit.edu	37	chr4	183658027	183658027	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctacttgagttccagagctGcagggtataagtcagttctc	10	10	2	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr4:183658027G>T	uc003ivd.1	+	16	3071	c.3034G>T	c.(3034-3036)GCA>TCA	p.A1012S	ODZ3_uc003ive.1_Missense_Mutation_p.A418S	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1012	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TTCCAGAGCTGCAGGGTATAA	0.388													T	183658027	T	T	183658027	3	4	123	1	0	0	0	0	1	0	0	0	10836	1319	46	5	3096	5	ODZ3	4	183658027	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	67891011	183658027	7496249	26	8467											
TRIML1	339976	broad.mit.edu	37	chr4	189063477	189063477	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caccagttcctgaaggaagaGgagcagctgcaactccagct	11	12	0	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr4:189063477G>C	uc003izm.1	+	3	691	c.576G>C	c.(574-576)GAG>GAC	p.E192D	TRIML1_uc003izn.1_5'Flank	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	192	Potential.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TGAAGGAAGAGGAGCAGCTGC	0.388													C	189063477	C	C	189063477	3	2	123	1	0	0	0	0	1	0	0	0	16547	991	35	5	586	5	TRIML1	4	189063477	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	5405450	189063477	2090799	27	8468											
G3BP1	10146	broad.mit.edu	37	chr5	151180343	151180343	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tatggaaacgtggtggagttGcgcattaacagtggtgggaa	16	4	0	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr5:151180343G>T	uc003lun.2	+	11	1278	c.1107G>T	c.(1105-1107)TTG>TTT	p.L369F	G3BP1_uc003lum.2_Missense_Mutation_p.L369F|G3BP1_uc011dcu.1_Missense_Mutation_p.L187F|G3BP1_uc010jhz.2_Missense_Mutation_p.L187F|G3BP1_uc003luq.2_Missense_Mutation_p.L37F	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	369	RRM.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			TGGTGGAGTTGCGCATTAACA	0.353													T	151180343	T	T	151180343	3	4	123	1	0	0	0	0	1	0	0	0	6141	1310	46	5	1145	5	G3BP1	5	151180343	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08		151180343	29734917	28	8469											
GRIA1	2890	broad.mit.edu	37	chr5	153030021	153030021	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctggagaagaaaaaggagCggctggtggtggtggactgt	18	5	0	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr5:153030021C>T	uc003lva.3	+	4	957	c.592C>T	c.(592-594)CGG>TGG	p.R198W	GRIA1_uc003luy.3_Missense_Mutation_p.R198W|GRIA1_uc003luz.3_Missense_Mutation_p.R103W|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.R118W|GRIA1_uc011dcx.1_Missense_Mutation_p.R129W|GRIA1_uc011dcy.1_Missense_Mutation_p.R208W|GRIA1_uc011dcz.1_Missense_Mutation_p.R208W|GRIA1_uc010jia.1_Missense_Mutation_p.R178W	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	198	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAAAAAGGAGCGGCTGGTGGT	0.542													T	153030021	T	T	153030021	3	4	123	1	0	0	0	0	1	0	0	0	6767	759	27	1	606	1	GRIA1	5	153030021	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	1849678	153030021	27885239	29	8470											
CCNG1	900	broad.mit.edu	37	chr5	162869506	162869506	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtttctgggcgtactgcaCggcaattgaagcatagctac	11	9	1	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr5:162869506C>T	uc003lzb.2	+	7	957	c.823C>T	c.(823-825)CGG>TGG	p.R275W	CCNG1_uc011dek.1_Missense_Mutation_p.R139W|CCNG1_uc011del.1_Missense_Mutation_p.R139W|CCNG1_uc003lzc.2_RNA	NM_199246	NP_954854	P51959	CCNG1_HUMAN	cyclin G1	275				RQLKHSYYRITHLPTIPEMVP -> LKWSLNWIITAPKNFS EAFLHNLVLWIP (in Ref. 4; AAB03903).	cell division|mitosis|regulation of cyclin-dependent protein kinase activity	nucleus				lung(1)|kidney(1)	2	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0597)|OV - Ovarian serous cystadenocarcinoma(192;0.107)|Epithelial(171;0.164)		GCGTACTGCACGGCAATTGAA	0.378													T	162869506	T	T	162869506	3	4	123	1	0	0	0	0	1	0	0	0	2923	527	19	1	841	1	CCNG1	5	162869506	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	9839485	162869506	18045754	30	8471											
PPP1R11	6992	broad.mit.edu	37	chr6	30035220	30035220	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggggctgggctgagcgagacCgtcactgagacaacggttac	16	10	1	3			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr6:30035220C>A	uc003npb.2	+	1	289	c.33C>A	c.(31-33)ACC>ACA	p.T11T	PPP1R11_uc010jrw.2_RNA|PPP1R11_uc003npc.2_RNA	NM_021959	NP_068778	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor)	11						soluble fraction	protein binding|protein phosphatase inhibitor activity			ovary(1)|lung(1)|skin(1)	3						TGAGCGAGACCGTCACTGAGA	0.632													A	30035220	A	A	30035220	2	1	123	1	0	0	0	0	0	0	0	1	12353	639	23	5		5	PPP1R11	6	30035220	Silent	SNP	C	TCGA-12-5295-01A-01D-1486-08		30035220	141079847	31	8472											
ENPP4	22875	broad.mit.edu	37	chr6	46107333	46107333	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgttcattatgaagttattaGtaatacttttgttttctgga	7	3	2	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr6:46107333G>C	uc003oxy.2	+	2	272	c.13G>C	c.(13-15)GTA>CTA	p.V5L		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	5						integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						GAAGTTATTAGTAATACTTTT	0.343													C	46107333	C	C	46107333	3	2	123	1	0	0	0	0	1	0	0	0	5132	1029	36	5	15	5	ENPP4	6	46107333	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	16072113	46107333	125007734	32	8473											
COL9A1	1297	broad.mit.edu	37	chr6	71004007	71004007	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtagcactactcctctccaCgccaatcatgatcttatgcc	5	15	3	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr6:71004007C>T	uc003pfg.3	-	5	718	c.559G>A	c.(559-561)GTG>ATG	p.V187M		NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	187	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						CTCCTCTCCACGCCAATCATG	0.433													T	71004007	T	T	71004007	3	4	123	1	0	0	0	0	1	0	0	0	3707	536	19	1	2418	1	COL9A1	6	71004007	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	24896674	71004007	100111060	33	8474											
TTK	7272	broad.mit.edu	37	chr6	80741263	80741263	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attaaagcagataggaagtgGaggttcaagcaaggtaagta	13	3	1	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr6:80741263G>A	uc003pjc.2	+	14	1675	c.1601G>A	c.(1600-1602)GGA>GAA	p.G534E	TTK_uc003pjb.3_Missense_Mutation_p.G533E	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	534	Protein kinase.|ATP (By similarity).				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		ATAGGAAGTGGAGGTTCAAGC	0.279													A	80741263	A	A	80741263	3	1	123	1	0	0	0	0	1	0	0	0	16717	1174	41	3	1651	3	TTK	6	80741263	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	9737256	80741263	90373804	34	8475											
TMEM181	57583	broad.mit.edu	37	chr6	159050767	159050767	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccttgacagcaccaccagccGagttcttatctttctatggc	7	14	3	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr6:159050767G>A	uc003qrm.3	+	15	1620	c.1609G>A	c.(1609-1611)GAG>AAG	p.E537K		NM_020823	NP_065874	Q9P2C4	TM181_HUMAN	G protein-coupled receptor 178	537					pathogenesis	integral to membrane	toxin binding			ovary(2)|central_nervous_system(1)	3		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		ACCACCAGCCGAGTTCTTATC	0.542													A	159050767	A	A	159050767	3	1	123	1	0	0	0	0	1	0	0	0	16097	1059	37	2	1667	2	TMEM181	6	159050767	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	78309504	159050767	12064300	35	8476											
FKBP9	11328	broad.mit.edu	37	chr7	33044873	33044873	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagctgattgtgaagaatatGttcaccaaccaggaccggaa	11	8	1	3			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr7:33044873G>A	uc003tdh.2	+	10	1804	c.1623G>A	c.(1621-1623)ATG>ATA	p.M541I	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Missense_Mutation_p.M594I|FKBP9_uc011kam.1_Missense_Mutation_p.M309I	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	541	EF-hand 2.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			TGAAGAATATGTTCACCAACC	0.493													A	33044873	A	A	33044873	3	1	123	1	0	0	0	0	1	0	0	0	5915	1377	48	3	1661	3	FKBP9	7	33044873	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08		33044873	126093790	36	8477											
STK17A	9263	broad.mit.edu	37	chr7	43622866	43622866	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccctttggagaagccaggCagcggcggctcctccccagg	13	15	0	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr7:43622866C>T	uc003tih.2	+	1	175	c.24C>T	c.(22-24)GGC>GGT	p.G8G		NM_004760	NP_004751	Q9UEE5	ST17A_HUMAN	serine/threonine kinase 17a	8					apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			skin(2)	2						AGAAGCCAGGCAGCGGCGGCT	0.567													T	43622866	T	T	43622866	2	4	123	1	0	0	0	0	0	0	0	1	15289	697	25	3		3	STK17A	7	43622866	Silent	SNP	C	TCGA-12-5295-01A-01D-1486-08	10577993	43622866	115515797	37	8478											
SLC26A5	375611	broad.mit.edu	37	chr7	103048353	103048353	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tctctttaaatctctcattaAactccttgccacccaacagc	2	15	3	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr7:103048353A>T	uc003vbz.2	-	8	1069	c.833T>A	c.(832-834)TTT>TAT	p.F278Y	SLC26A5_uc003vbt.1_Missense_Mutation_p.F278Y|SLC26A5_uc003vbu.1_Missense_Mutation_p.F278Y|SLC26A5_uc003vbv.1_Missense_Mutation_p.F278Y|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.F278Y|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	278	Cytoplasmic (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TCTCTCATTAAACTCCTTGCC	0.468													T	103048353	T	T	103048353	3	4	123	1	0	0	0	0	1	0	0	0	14520	14	1	5	1494	5	SLC26A5	7	103048353	Missense_Mutation	SNP	A	TCGA-12-5295-01A-01D-1486-08	59425487	103048353	56090310	38	8479											
CFTR	1080	broad.mit.edu	37	chr7	117306983	117306983	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatagaagagaacaaagtgCggcagtacgattccatccag	10	9	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr7:117306983C>T	uc003vjd.2	+	27	4396	c.4264C>T	c.(4264-4266)CGG>TGG	p.R1422W	CFTR_uc011knq.1_Missense_Mutation_p.R828W	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1422	Cytoplasmic (Potential).|ABC transporter 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GAACAAAGTGCGGCAGTACGA	0.552									Cystic_Fibrosis				T	117306983	T	T	117306983	3	4	123	1	0	0	0	0	1	0	0	0	3294	759	27	1	4370	1	CFTR	7	117306983	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	14258630	117306983	41831680	39	8480											
KIAA1549	57670	broad.mit.edu	37	chr7	138546043	138546043	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctggctgctgggggccacgaGggcaaaggcgtcgtccagga	18	11	0	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr7:138546043G>C	uc011kql.1	-	16	5138	c.5089C>G	c.(5089-5091)CTC>GTC	p.L1697V	KIAA1549_uc011kqi.1_Missense_Mutation_p.L481V|KIAA1549_uc003vuk.3_Missense_Mutation_p.L1647V|KIAA1549_uc011kqj.1_Missense_Mutation_p.L1697V|KIAA1549_uc011kqk.1_Missense_Mutation_p.L481V	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1697						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GGGGCCACGAGGGCAAAGGCG	0.697			O	BRAF	pilocytic astrocytoma								C	138546043	C	C	138546043	3	2	123	1	0	0	0	0	1	0	0	0	8244	1000	35	5	783	5	KIAA1549	7	138546043	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	21239060	138546043	20592620	40	8481											
PARP12	64761	broad.mit.edu	37	chr7	139727128	139727128	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tactcgctcaatcttctgaaCaaagtagaaaggcagcgtgc	9	10	3	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr7:139727128C>A	uc003vvl.1	-	10	2450	c.1576G>T	c.(1576-1578)GTT>TTT	p.V526F	PARP12_uc003vvk.1_Missense_Mutation_p.V312F|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	526	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					ATCTTCTGAACAAAGTAGAAA	0.512													A	139727128	A	A	139727128	3	1	123	1	0	0	0	0	1	0	0	0	11457	478	17	5	541	5	PARP12	7	139727128	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	1181085	139727128	19411535	41	8482											
OR2A14	135941	broad.mit.edu	37	chr7	143826811	143826811	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggtcatctttgcagcctgCgtgttcatcctggtggggcc	14	11	3	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr7:143826811C>T	uc011kua.1	+	1	606	c.606C>T	c.(604-606)TGC>TGT	p.C202C		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TTGCAGCCTGCGTGTTCATCC	0.577													T	143826811	T	T	143826811	2	4	123	1	0	0	0	0	0	0	0	1	10976	776	27	1		1	OR2A14	7	143826811	Silent	SNP	C	TCGA-12-5295-01A-01D-1486-08	4099683	143826811	15311852	42	8483											
CNTNAP2	26047	broad.mit.edu	37	chr7	147092850	147092850	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gtttcgcgaatgtcagcattGacatgtgtgcgatcatagac	11	8	2	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr7:147092850G>C	uc003weu.1	+	10	2164	c.1648G>C	c.(1648-1650)GAC>CAC	p.D550H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	550	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGTCAGCATTGACATGTGTGC	0.428										HNSCC(39;0.1)			C	147092850	C	C	147092850	3	2	123	1	0	0	0	0	1	0	0	0	3647	1290	45	5	1686	5	CNTNAP2	7	147092850	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	3266039	147092850	12045813	43	8484											
DLC1	10395	broad.mit.edu	37	chr8	13251148	13251148	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcagaagacaaatttactcGtgtctgatttactgaaatgg	9	6	2	4			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr8:13251148G>A	uc003wwm.2	-	4	1672	c.1228C>T	c.(1228-1230)CGA>TGA	p.R410*	DLC1_uc003wwn.2_Nonsense_Mutation_p.R410*|DLC1_uc011kxy.1_Nonsense_Mutation_p.R410*	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	410					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						AAATTTACTCGTGTCTGATTT	0.423													A	13251148	A	A	13251148	4	1	123	1	0	0	0	0	0	1	0	0	4550	1153	40	1	3503	1	DLC1	8	13251148	Nonsense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08		13251148	133112874	44	8485											
MTUS1	57509	broad.mit.edu	37	chr8	17573333	17573333	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggataccaaaggcttcaaatAaaaggatcctgaggaaccat	9	8	1	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr8:17573333A>G	uc003wxv.2	-	5	3001	c.2527T>C	c.(2527-2529)TAT>CAT	p.Y843H	MTUS1_uc003wxt.2_Missense_Mutation_p.Y90H|MTUS1_uc011kyg.1_5'UTR|MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.Y789H	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	843						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GGCTTCAAATAAAAGGATCCT	0.428													G	17573333	G	G	17573333	3	3	123	1	0	0	0	0	1	0	0	0	9965	362	13	4	1454	4	MTUS1	8	17573333	Missense_Mutation	SNP	A	TCGA-12-5295-01A-01D-1486-08	4322185	17573333	128790689	45	8486											
ATAD2	29028	broad.mit.edu	37	chr8	124382139	124382139	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctgattctcttcttctccatCttcttcatcttcatcatctt	1	14	10	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr8:124382139C>T	uc003yqh.3	-	7	961	c.853G>A	c.(853-855)GAT>AAT	p.D285N	ATAD2_uc011lii.1_Missense_Mutation_p.D76N|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.D285N	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	285	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			tcttctccatcttcttcatct	0.159													T	124382139	T	T	124382139	3	4	123	1	0	0	0	0	1	0	0	0	1071	913	32	3	3407	3	ATAD2	8	124382139	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	106808806	124382139	21981883	46	8487											
FREM1	158326	broad.mit.edu	37	chr9	14789086	14789086	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagtgcatttcatgccaggGgagagaggaacccagtccct	13	10	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr9:14789086G>A	uc003zlm.2	-	23	4598	c.4008C>T	c.(4006-4008)TCC>TCT	p.S1336S	FREM1_uc010mic.2_Intron	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1336	CSPG 9.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TCATGCCAGGGGAGAGAGGAA	0.493													A	14789086	A	A	14789086	2	1	123	1	0	0	0	0	0	0	0	1	6044	1219	43	3		3	FREM1	9	14789086	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08		14789086	126424345	47	8488											
TEK	7010	broad.mit.edu	37	chr9	27205000	27205000	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	actgtgctgttggcctttctGatcatattgcaattgaagag	10	7	2	3			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr9:27205000G>A	uc003zqi.3	+	14	2743	c.2301G>A	c.(2299-2301)CTG>CTA	p.L767L	TEK_uc011lno.1_Silent_p.L724L|TEK_uc011lnp.1_Silent_p.L620L|TEK_uc003zqj.1_Silent_p.L701L	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	767	Helical; (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TGGCCTTTCTGATCATATTGC	0.517													A	27205000	A	A	27205000	2	1	123	1	0	0	0	0	0	0	0	1	15748	1277	45	3		3	TEK	9	27205000	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08	12415914	27205000	114008431	48	8489											
UBAP1	51271	broad.mit.edu	37	chr9	34234331	34234331	+	Frame_Shift_Del	DEL	A	-	-													ttgtttgcaggttgtcagagAagtacaggtaagtggtaatt							TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr9:34234331delA	uc003ztx.2	+	3	387	c.152delA	c.(151-153)GAAfs	p.E51fs	UBAP1_uc010mka.1_Intron|UBAP1_uc003zty.2_Frame_Shift_Del_p.E51fs|UBAP1_uc011loi.1_Intron|UBAP1_uc011loj.1_Frame_Shift_Del_p.E115fs|KIF24_uc010mkb.2_Intron|UBAP1_uc003ztz.2_Frame_Shift_Del_p.E51fs	NM_016525	NP_057609	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	51	UMA.					cytoplasm					0			LUSC - Lung squamous cell carcinoma(29;0.00272)			GTTGTCAGAGAAGTACAGGTA	0.318													-	34234331	-	-	34234331	7	5	123	1	0	1	0	1	0	0	0	0	16833	246	9	0	395	0	UBAP1	9	34234331	Frame_Shift_Del	DEL	A	TCGA-12-5295-01A-01D-1486-08	7029331	34234331	106979100	49	8490											
VPS13A	23230	broad.mit.edu	37	chr9	79985216	79985216	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtttgtggaaggaatggcacTaggacttaaggcactagttg	14	5	0	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr9:79985216T>C	uc004akr.2	+	64	8971	c.8711T>C	c.(8710-8712)CTA>CCA	p.L2904P	VPS13A_uc004akp.3_Missense_Mutation_p.L2904P|VPS13A_uc004akq.3_Missense_Mutation_p.L2904P|VPS13A_uc004aks.2_Missense_Mutation_p.L2865P	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2904					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						GGAATGGCACTAGGACTTAAG	0.373													C	79985216	C	C	79985216	3	2	123	1	0	0	0	0	1	0	0	0	17186	1522	53	4	8965	4	VPS13A	9	79985216	Missense_Mutation	SNP	T	TCGA-12-5295-01A-01D-1486-08	45750885	79985216	61228215	50	8491											
BTAF1	9044	broad.mit.edu	37	chr10	93756207	93756207	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatggctgctcgttgtgtaGgtgtcatgagcaaaatagct	12	7	1	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr10:93756207G>A	uc001khr.2	+	24	3489	c.3391G>A	c.(3391-3393)GGT>AGT	p.G1131S	BTAF1_uc001kht.1_Missense_Mutation_p.G569S	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1131	HEAT 7.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TCGTTGTGTAGGTGTCATGAG	0.423													A	93756207	A	A	93756207	3	1	123	1	0	0	0	0	1	0	0	0	1536	1000	35	3	3485	3	BTAF1	10	93756207	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08		93756207	41778540	51	8492											
CYP2C18	1562	broad.mit.edu	37	chr10	96447958	96447958	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actctgcggaattttgggatGgggaagaggagcatcgagga	17	5	1	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr10:96447958G>A	uc001kjv.3	+	3	734	c.408G>A	c.(406-408)ATG>ATA	p.M136I	CYP2C18_uc001kjw.3_Missense_Mutation_p.M136I|CYP2C19_uc009xus.1_Missense_Mutation_p.M1I|CYP2C19_uc010qny.1_5'UTR	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	136					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		ATTTTGGGATGGGGAAGAGGA	0.478													A	96447958	A	A	96447958	3	1	123	1	0	0	0	0	1	0	0	0	4165	1348	47	3	418	3	CYP2C18	10	96447958	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	2691751	96447958	39086789	52	8493											
TDRD1	56165	broad.mit.edu	37	chr10	115947725	115947725	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagtctttaagaagtcctggAacacttcctaaccaccctaa	6	12	1	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr10:115947725A>G	uc001lbg.1	+	2	288	c.135A>G	c.(133-135)GGA>GGG	p.G45G	TDRD1_uc001lbf.2_Silent_p.G36G|TDRD1_uc001lbh.1_Silent_p.G36G|TDRD1_uc001lbi.1_Silent_p.G36G	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	45					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GAAGTCCTGGAACACTTCCTA	0.358													G	115947725	G	G	115947725	2	3	123	1	0	0	0	0	0	0	0	1	15727	233	9	4		4	TDRD1	10	115947725	Silent	SNP	A	TCGA-12-5295-01A-01D-1486-08	19499767	115947725	19587022	53	8494											
KRTAP5-3	387266	broad.mit.edu	37	chr11	1629152	1629152	+	Missense_Mutation	SNP	C	G	G													tacagcagctggactgggagCagctgggcttgcagcagctg							TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr11:1629152C>G	uc001ltw.1	-	1	542	c.464G>C	c.(463-465)TGC>TCC	p.C155S		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	155	11 X 4 AA repeats of C-C-X-P.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		GGACTGGGAGCAGCTGGGCTT	0.388													G	1629152	G	G	1629152	3	3	123	1	0	0	0	0	1	0	0	0	8562	710	25	5	256	5	KRTAP5-3	11	1629152	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08		1629152	133377364	54	8495	12	2									
KRTAP5-3	387266	broad.mit.edu	37	chr11	1629156	1629156	+	Missense_Mutation	SNP	T	A	A													gcagctggactgggagcagcTgggcttgcagcagctggact					rs75371407		TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr11:1629156T>A	uc001ltw.1	-	1	538	c.460A>T	c.(460-462)AGC>TGC	p.S154C		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	154	11 X 4 AA repeats of C-C-X-P.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		TGGGAGCAGCTGGGCTTGCAG	0.403													A	1629156	A	A	1629156	3	1	123	1	0	0	0	0	1	0	0	0	8562	1580	55	5	260	5	KRTAP5-3	11	1629156	Missense_Mutation	SNP	T	TCGA-12-5295-01A-01D-1486-08	4	1629156	133377360	55	8496	12	2									
OR51G1	79324	broad.mit.edu	37	chr11	4945317	4945317	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtatcaaaccagaaaatgcCcagcacagtgggcagtgtgg	13	9	1	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr11:4945317C>T	uc010qyr.1	-	1	253	c.253G>A	c.(253-255)GGC>AGC	p.G85S		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGAAAATGCCCAGCACAGTG	0.483													T	4945317	T	T	4945317	3	4	123	1	0	0	0	0	1	0	0	0	11098	623	22	3	714	3	OR51G1	11	4945317	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	3316161	4945317	130061199	56	8497											
OR10A6	390093	broad.mit.edu	37	chr11	7949483	7949483	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcacagatgtgaggtgagCggcacaggtggaaaaggcct	17	7	1	3			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr11:7949483C>T	uc010rbh.1	-	1	727	c.727G>A	c.(727-729)GCT>ACT	p.A243T		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTGAGGTGAGCGGCACAGGTG	0.453													T	7949483	T	T	7949483	3	4	123	1	0	0	0	0	1	0	0	0	10894	768	27	1	220	1	OR10A6	11	7949483	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	3004166	7949483	127057033	57	8498											
KCNA4	3739	broad.mit.edu	37	chr11	30033870	30033870	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcctcctcactcagctccCtcaggatcttctcctcagag	5	19	6	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr11:30033870C>T	uc001msk.2	-	2	1508	c.356G>A	c.(355-357)AGG>AAG	p.R119K		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	119						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ACTCAGCTCCCTCAGGATCTT	0.408													T	30033870	T	T	30033870	3	4	123	1	0	0	0	0	1	0	0	0	8005	681	24	3	1609	3	KCNA4	11	30033870	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	22084387	30033870	104972646	58	8499											
EHBP1L1	254102	broad.mit.edu	37	chr11	65349460	65349460	+	Frame_Shift_Del	DEL	A	-	-													agacatgtggacactaagggAccagaggcgacaggggtgat							TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr11:65349460delA	uc001oeo.3	+	9	1582	c.1317delA	c.(1315-1317)GGAfs	p.G439fs	EHBP1L1_uc001oep.1_Intron	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	439										central_nervous_system(1)	1						ACACTAAGGGACCAGAGGCGA	0.597													-	65349460	-	-	65349460	7	5	123	1	0	1	0	1	0	0	0	0	4976	262	10	0	1351	0	EHBP1L1	11	65349460	Frame_Shift_Del	DEL	A	TCGA-12-5295-01A-01D-1486-08	35315590	65349460	69657056	59	8500											
ODZ4	26011	broad.mit.edu	37	chr11	78380300	78380300	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagacagcaagaggggtccCgatgttgtcacaagctatgt	12	8	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr11:78380300C>T	uc001ozl.3	-	32	7553	c.7090G>A	c.(7090-7092)GGG>AGG	p.G2364R	ODZ4_uc001ozk.3_Missense_Mutation_p.G589R|ODZ4_uc009yvb.1_Missense_Mutation_p.G948R	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2364	Extracellular (Potential).|YD 23.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						AGAGGGGTCCCGATGTTGTCA	0.483													T	78380300	T	T	78380300	3	4	123	1	0	0	0	0	1	0	0	0	10837	652	23	2	1231	2	ODZ4	11	78380300	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	13030840	78380300	56626216	60	8501											
TMEM135	65084	broad.mit.edu	37	chr11	86778833	86778833	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atttctaactgctaatggggCcttgtatatggctttctttt	8	7	2	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr11:86778833C>A	uc001pch.2	+	2	262	c.239C>A	c.(238-240)GCC>GAC	p.A80D	TMEM135_uc010rtt.1_5'UTR|TMEM135_uc001pci.2_Missense_Mutation_p.A80D|TMEM135_uc001pcg.1_Missense_Mutation_p.A80D	NM_022918	NP_075069	Q86UB9	TM135_HUMAN	transmembrane protein 135	80	Helical; (Potential).					integral to membrane					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GCTAATGGGGCCTTGTATATG	0.358													A	86778833	A	A	86778833	3	1	123	1	0	0	0	0	1	0	0	0	16048	739	26	5	245	5	TMEM135	11	86778833	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	8398533	86778833	48227683	61	8502											
MTNR1B	4544	broad.mit.edu	37	chr11	92715081	92715081	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgctggtgcttcaggcccGcaggaaagccaagccagaga	15	11	1	1	rs8192553	byFrequency	TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr11:92715081G>A	uc001pdk.1	+	2	795	c.692G>A	c.(691-693)CGC>CAC	p.R231H		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	231	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CTTCAGGCCCGCAGGAAAGCC	0.582													A	92715081	A	A	92715081	3	1	123	1	0	0	0	0	1	0	0	0	9952	1087	38	1	698	1	MTNR1B	11	92715081	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	5936248	92715081	42291435	62	8503											
ITPR2	3709	broad.mit.edu	37	chr12	26835518	26835518	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacatttacctttaacataaCaggcctctcttcatctgtgt	5	11	3	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr12:26835518C>T	uc001rhg.2	-	12	1654	c.1237G>A	c.(1237-1239)GTT>ATT	p.V413I		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	413	Cytoplasmic (Potential).|MIR 5.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TTTAACATAACAGGCCTCTCT	0.388													T	26835518	T	T	26835518	3	4	123	1	0	0	0	0	1	0	0	0	7921	478	17	3	7052	3	ITPR2	12	26835518	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08		26835518	107016377	63	8504											
CCNT1	904	broad.mit.edu	37	chr12	49086898	49086898	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtctgtattgccagatctcGaggagattccaccagaccga	10	11	2	3			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr12:49086898G>A	uc001rse.1	-	9	2422	c.2099C>T	c.(2098-2100)TCG>TTG	p.S700L	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.S415L	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	700					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						GCCAGATCTCGAGGAGATTCC	0.507													A	49086898	A	A	49086898	3	1	123	1	0	0	0	0	1	0	0	0	2934	1059	37	2	85	2	CCNT1	12	49086898	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	22251380	49086898	84764997	64	8505											
ITGB7	3695	broad.mit.edu	37	chr12	53585372	53585372	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actgtctgcctcttgaaagcGaggattgatggtggtcgtga	14	7	2	3	rs141610554	byFrequency	TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr12:53585372G>A	uc009zmv.2	-	15	2436	c.2365C>T	c.(2365-2367)CGC>TGC	p.R789C	ITGB7_uc001scc.2_Missense_Mutation_p.R789C|ITGB7_uc010snz.1_RNA	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	789	Cytoplasmic (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						TCTTGAAAGCGAGGATTGATG	0.507													A	53585372	A	A	53585372	3	1	123	1	0	0	0	0	1	0	0	0	7900	1058	37	2	35	2	ITGB7	12	53585372	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	4498474	53585372	80266523	65	8506											
LEMD3	23592	broad.mit.edu	37	chr12	65633734	65633734	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgatggtttgtgtcgttctGcgttacatgaaatatcgatg	12	5	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr12:65633734G>A	uc001ssl.1	+	7	1953	c.1947G>A	c.(1945-1947)CTG>CTA	p.L649L	LEMD3_uc009zqo.1_Silent_p.L648L	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	649					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GTGTCGTTCTGCGTTACATGA	0.294													A	65633734	A	A	65633734	2	1	123	1	0	0	0	0	0	0	0	1	8721	1306	46	3		3	LEMD3	12	65633734	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08	12048362	65633734	68218161	66	8507											
CCT2	10576	broad.mit.edu	37	chr12	69985894	69985894	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaacgaattgaaaatgcTaaaattcttattgcaaatac	4	7	1	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr12:69985894T>G	uc001svb.1	+	8	799	c.705T>G	c.(703-705)GCT>GCG	p.A235A	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Silent_p.A235A|CCT2_uc010stl.1_Silent_p.A188A	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	235					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TTGAAAATGCTAAAATTCTTA	0.239													G	69985894	G	G	69985894	2	3	123	1	0	0	0	0	0	0	0	1	2953	1509	53	5		5	CCT2	12	69985894	Silent	SNP	T	TCGA-12-5295-01A-01D-1486-08	4352160	69985894	63866001	67	8508											
SCARB1	949	broad.mit.edu	37	chr12	125294730	125294730	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	cagtgattaccggcaggcctCcgggctgtagaactccagcg	13	13	0	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr12:125294730C>A	uc001ugo.3	-	6	1085	c.832G>T	c.(832-834)GAG>TAG	p.E278*	SCARB1_uc001ugn.3_Nonsense_Mutation_p.E278*|SCARB1_uc001ugm.3_Nonsense_Mutation_p.E278*|SCARB1_uc010tbd.1_Nonsense_Mutation_p.E278*|SCARB1_uc010tbe.1_Nonsense_Mutation_p.E237*|SCARB1_uc001ugp.3_Nonsense_Mutation_p.E278*	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	278	Extracellular (Potential).				adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	CGGCAGGCCTCCGGGCTGTAG	0.552													A	125294730	A	A	125294730	4	1	123	1	0	0	0	0	0	1	0	0	13881	864	30	5	849	5	SCARB1	12	125294730	Nonsense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	55308836	125294730	8557165	68	8509											
MYO16	23026	broad.mit.edu	37	chr13	109792874	109792874	+	Frame_Shift_Del	DEL	G	-	-													cctgtgtacatcgagatgctGgggcacgcggccaggcccga							TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr13:109792874delG	uc001vqt.1	+	32	4374	c.4248delG	c.(4246-4248)CTGfs	p.L1416fs	MYO16_uc010agk.1_Frame_Shift_Del_p.L1438fs	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1416	Pro-rich.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCGAGATGCTGGGGCACGCGG	0.736													-	109792874	-	-	109792874	7	5	123	1	0	1	0	1	0	0	0	0	10064	1335	47	0	4370	0	MYO16	13	109792874	Frame_Shift_Del	DEL	G	TCGA-12-5295-01A-01D-1486-08		109792874	5377004	69	8510											
OR4K13	390433	broad.mit.edu	37	chr14	20502107	20502107	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aattgtgtaaaacacagaaaGaattttatctaccgagtatc	6	6	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr14:20502107G>A	uc010tkz.1	-	1	811	c.811C>T	c.(811-813)CTT>TTT	p.L271F		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	271	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AACACAGAAAGAATTTTATCT	0.378													A	20502107	A	A	20502107	3	1	123	1	0	0	0	0	1	0	0	0	11068	942	33	3	105	3	OR4K13	14	20502107	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08		20502107	86847433	70	8511											
C14orf43	91748	broad.mit.edu	37	chr14	74203800	74203800	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctgttcaggacccttcccGtcctcatcaagacctccagc	6	17	4	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr14:74203800G>A	uc001xot.2	-	3	2433	c.1650C>T	c.(1648-1650)GAC>GAT	p.D550D	C14orf43_uc001xou.2_Silent_p.D550D|C14orf43_uc010tud.1_Silent_p.D550D|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	550					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		GACCCTTCCCGTCCTCATCAA	0.602													A	74203800	A	A	74203800	2	1	123	1	0	0	0	0	0	0	0	1	1774	1136	40	1		1	C14orf43	14	74203800	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08	53701693	74203800	33145740	71	8512											
NUDT14	256281	broad.mit.edu	37	chr14	105642875	105642875	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcctggtcccactcaccagtAtgtggcgacccggcgcagat	12	15	1	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr14:105642875A>T	uc010tyn.1	-	4	538	c.424T>A	c.(424-426)TAC>AAC	p.Y142N	NUDT14_uc001yqi.2_RNA	NM_177533	NP_803877	O95848	NUD14_HUMAN	nudix-type motif 14	142	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity			skin(1)	1		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		ACTCACCAGTATGTGGCGACC	0.478										HNSCC(42;0.11)			T	105642875	T	T	105642875	3	4	123	1	0	0	0	0	1	0	0	0	10730	449	16	5	252	5	NUDT14	14	105642875	Missense_Mutation	SNP	A	TCGA-12-5295-01A-01D-1486-08	31439075	105642875	1706665	72	8513											
TJP1	7082	broad.mit.edu	37	chr15	30000963	30000963	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttcacttggcagaagattGtgattgaatttaggactttc	10	5	1	4			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr15:30000963G>A	uc001zcr.2	-	25	5125	c.4650C>T	c.(4648-4650)CAC>CAT	p.H1550H	TJP1_uc010azl.2_Silent_p.H1538H|TJP1_uc001zcq.2_Silent_p.H1474H|TJP1_uc001zcs.2_Silent_p.H1470H	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1550					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GCAGAAGATTGTGATTGAATT	0.413													A	30000963	A	A	30000963	2	1	123	1	0	0	0	0	0	0	0	1	15926	1368	48	3		3	TJP1	15	30000963	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08		30000963	72530429	73	8514											
BAHD1	22893	broad.mit.edu	37	chr15	40750817	40750817	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggtcacctcacagggcgcCgcaagaattacccacttcgt	9	15	2	1	rs144910683		TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr15:40750817C>T	uc001zlu.2	+	2	225	c.154C>T	c.(154-156)CGC>TGC	p.R52C	BAHD1_uc001zlt.2_Missense_Mutation_p.R52C|BAHD1_uc010bbp.1_Missense_Mutation_p.R52C|BAHD1_uc001zlv.2_Missense_Mutation_p.R52C	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	52					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CACAGGGCGCCGCAAGAATTA	0.632													T	40750817	T	T	40750817	3	4	123	1	0	0	0	0	1	0	0	0	1297	652	23	2	156	2	BAHD1	15	40750817	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	10749854	40750817	61780575	74	8515											
SLCO3A1	28232	broad.mit.edu	37	chr15	92690225	92690225	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctttcagaatctcacgggCtgtgcgtgcctcaccaccgt	9	16	3	1			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr15:92690225C>T	uc002bqx.2	+	8	1725	c.1524C>T	c.(1522-1524)GGC>GGT	p.G508G	SLCO3A1_uc002bqy.2_Silent_p.G508G|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Silent_p.G450G	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	508	Extracellular (Potential).|Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			ATCTCACGGGCTGTGCGTGCC	0.557													T	92690225	T	T	92690225	2	4	123	1	0	0	0	0	0	0	0	1	14728	784	28	3		3	SLCO3A1	15	92690225	Silent	SNP	C	TCGA-12-5295-01A-01D-1486-08	51939408	92690225	9841167	75	8516											
SSTR5	6755	broad.mit.edu	37	chr16	1129429	1129429	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggagggcggtacctgcaaCgccagctggccggagcccgt	16	14	0	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr16:1129429C>T	uc002ckq.2	+	1	649	c.561C>T	c.(559-561)AAC>AAT	p.N187N	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	187	Extracellular (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	GTACCTGCAACGCCAGCTGGC	0.692													T	1129429	T	T	1129429	2	4	123	1	0	0	0	0	0	0	0	1	15200	535	19	1		1	SSTR5	16	1129429	Silent	SNP	C	TCGA-12-5295-01A-01D-1486-08		1129429	89225324	76	8517											
MYH8	4626	broad.mit.edu	37	chr17	10295897	10295897	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactcgtcgctcatgtttccGtaaacctttaacagcctctg	6	13	2	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr17:10295897G>A	uc002gmm.2	-	38	5625	c.5530C>T	c.(5530-5532)CGG>TGG	p.R1844W	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1844	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TCATGTTTCCGTAAACCTTTA	0.433									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				A	10295897	A	A	10295897	3	1	123	1	0	0	0	0	1	0	0	0	10041	1144	40	1	295	1	MYH8	17	10295897	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08		10295897	70899313	77	8518											
STAT3	6774	broad.mit.edu	37	chr17	40474479	40474479	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttgttcagctgctgctttGtgtatggttccacggactgg	13	8	1	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr17:40474479G>A	uc002hzl.1	-	21	2162	c.1922C>T	c.(1921-1923)ACA>ATA	p.T641I	STAT3_uc002hzk.1_Missense_Mutation_p.T641I|STAT3_uc002hzm.1_Missense_Mutation_p.T641I|STAT3_uc010wgh.1_Missense_Mutation_p.T543I|STAT3_uc002hzn.1_Missense_Mutation_p.T641I	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	641	SH2.				cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		CTGCTGCTTTGTGTATGGTTC	0.463									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				A	40474479	A	A	40474479	3	1	123	1	0	0	0	0	1	0	0	0	15265	1377	48	3	406	3	STAT3	17	40474479	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	30178582	40474479	40720731	78	8519											
LRRC30	339291	broad.mit.edu	37	chr18	7231759	7231759	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgctgagagcatccagcaccTggccagcctgcagatcttca	10	15	2	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr18:7231759T>C	uc010wzk.1	+	1	623	c.623T>C	c.(622-624)CTG>CCG	p.L208P		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	208	LRR 6.									ovary(1)|liver(1)	2						ATCCAGCACCTGGCCAGCCTG	0.562													C	7231759	C	C	7231759	3	2	123	1	0	0	0	0	1	0	0	0	8985	1580	55	4	625	4	LRRC30	18	7231759	Missense_Mutation	SNP	T	TCGA-12-5295-01A-01D-1486-08		7231759	70845489	79	8520											
DCC	1630	broad.mit.edu	37	chr18	50278484	50278484	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaaccttctgatgccgtcaCaatgcggggaggaaatgtcc	12	10	2	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr18:50278484C>T	uc002lfe.1	+	2	739	c.152C>T	c.(151-153)ACA>ATA	p.T51I	DCC_uc010xdr.1_5'UTR	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	51	Extracellular (Potential).|Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GATGCCGTCACAATGCGGGGA	0.498													T	50278484	T	T	50278484	3	4	123	1	0	0	0	0	1	0	0	0	4282	478	17	3	158	3	DCC	18	50278484	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	43046725	50278484	27798764	80	8521											
MUC16	94025	broad.mit.edu	37	chr19	9006685	9006685	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatgttgaacttcctggagCcagggtgacccatgttctcc	11	11	1	3			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr19:9006685C>T	uc002mkp.2	-	44	39767	c.39563G>A	c.(39562-39564)GGC>GAC	p.G13188D	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.G5D|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13190	SEA 8.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTTCCTGGAGCCAGGGTGACC	0.527													T	9006685	T	T	9006685	3	4	123	1	0	0	0	0	1	0	0	0	9973	739	26	3	4124	3	MUC16	19	9006685	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08		9006685	50122298	81	8522											
CYP2A13	1553	broad.mit.edu	37	chr19	41600897	41600897	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccctatgctgggctccgtgCtgagagaccccaggttcttc	11	14	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr19:41600897C>T	uc002opt.2	+	8	1204	c.1195C>T	c.(1195-1197)CTG>TTG	p.L399L		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	399					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	GGGCTCCGTGCTGAGAGACCC	0.557													T	41600897	T	T	41600897	2	4	123	1	0	0	0	0	0	0	0	1	4161	796	28	3		3	CYP2A13	19	41600897	Silent	SNP	C	TCGA-12-5295-01A-01D-1486-08	32594212	41600897	17528086	82	8523											
PSG8	440533	broad.mit.edu	37	chr19	43258694	43258694	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtagaggacttctcctgaaCggtaataggtgaatgaaggg	14	5	1	4	rs148019273	byFrequency	TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr19:43258694C>T	uc002ouo.2	-	5	1132	c.1034G>A	c.(1033-1035)CGT>CAT	p.R345H	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Missense_Mutation_p.R184H|PSG8_uc002ouh.2_Missense_Mutation_p.R345H|PSG8_uc010ein.2_Missense_Mutation_p.R223H|PSG8_uc002ouj.3_Missense_Mutation_p.R127H|PSG8_uc002ouk.3_Missense_Mutation_p.R184H|PSG8_uc002oul.3_Missense_Mutation_p.R345H|PSG8_uc002oum.3_Missense_Mutation_p.R252H|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.R252H	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	345	Ig-like C2-type 3.					extracellular region					0		Prostate(69;0.00899)				TTCTCCTGAACGGTAATAGGT	0.473													T	43258694	T	T	43258694	3	4	123	1	0	0	0	0	1	0	0	0	12661	536	19	1	271	1	PSG8	19	43258694	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	1657797	43258694	15870289	83	8524											
CEACAM16	388551	broad.mit.edu	37	chr19	45208902	45208902	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctccaggattccaccacccGcacaggctgcaccatcaaag	7	18	1	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr19:45208902G>T	uc010xxd.1	+	5	910	c.704G>T	c.(703-705)CGC>CTC	p.R235L	CEACAM16_uc002ozq.2_Missense_Mutation_p.R294L	NM_001039213	NP_001034302	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion	235										ovary(1)	1	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				TCCACCACCCGCACAGGCTGC	0.612													T	45208902	T	T	45208902	3	4	123	1	0	0	0	0	1	0	0	0	3188	1087	38	5	718	5	CEACAM16	19	45208902	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	1950208	45208902	13920081	84	8525											
TEAD2	8463	broad.mit.edu	37	chr19	49862740	49862740	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcagcttgatgtagcgggcGatcagttcattccgacctga	11	11	3	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr19:49862740G>A	uc002pnj.2	-	3	340	c.249C>T	c.(247-249)ATC>ATT	p.I83I	TEAD2_uc002png.2_Silent_p.I83I|TEAD2_uc002pnh.2_Silent_p.I83I|TEAD2_uc002pni.2_Silent_p.I83I|TEAD2_uc010yao.1_5'UTR|TEAD2_uc010emw.2_Silent_p.I83I	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	83	TEA.				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		TGTAGCGGGCGATCAGTTCAT	0.512													A	49862740	A	A	49862740	2	1	123	1	0	0	0	0	0	0	0	1	15736	1048	37	2		2	TEAD2	19	49862740	Silent	SNP	G	TCGA-12-5295-01A-01D-1486-08	4653838	49862740	9266243	85	8526											
BMP2	650	broad.mit.edu	37	chr20	6758901	6758901	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tatcaaattagaatctttggAagaactaccagaaacgagtg	8	6	2	3			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr20:6758901A>T	uc002wmu.1	+	3	1141	c.356A>T	c.(355-357)GAA>GTA	p.E119V		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	119					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	GAATCTTTGGAAGAACTACCA	0.363													T	6758901	T	T	6758901	3	4	123	1	0	0	0	0	1	0	0	0	1459	246	9	5	362	5	BMP2	20	6758901	Missense_Mutation	SNP	A	TCGA-12-5295-01A-01D-1486-08		6758901	56266619	86	8527											
PLK1S1	55857	broad.mit.edu	37	chr20	21143040	21143040	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cacgggaacatattgaagttGaggaaaaaagagccagcccg	12	8	0	3			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chr20:21143040G>A	uc002wsb.2	+	5	1067	c.934G>A	c.(934-936)GAG>AAG	p.E312K	PLK1S1_uc010zsh.1_Missense_Mutation_p.E209K|PLK1S1_uc010zsi.1_Missense_Mutation_p.E179K|PLK1S1_uc010zsj.1_RNA|uc002wsc.2_Intron|PLK1S1_uc002wsd.2_RNA	NM_018474	NP_060944	Q2M2Z5	KIZ_HUMAN	polo-like kinase 1 substrate 1 isoform 1	312					spindle organization	centrosome	protein kinase binding				0						TATTGAAGTTGAGGAAAAAAG	0.448													A	21143040	A	A	21143040	3	1	123	1	0	0	0	0	1	0	0	0	12095	1291	45	3	952	3	PLK1S1	20	21143040	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	14384139	21143040	41882480	87	8528											
FOXR2	139628	broad.mit.edu	37	chrX	55650313	55650313	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtcggagtaatgaagcccCcagaaatgcctcagaagagg	13	9	1	4			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chrX:55650313C>T	uc004duo.2	+	1	481	c.169C>T	c.(169-171)CCA>TCA	p.P57S		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	57					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						AATGAAGCCCCCAGAAATGCC	0.517													T	55650313	T	T	55650313	3	4	123	1	0	0	0	0	1	0	0	0	6032	623	22	3	171	3	FOXR2	23	55650313	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08		55650313	99620247	88	8529											
YIPF6	286451	broad.mit.edu	37	chrX	67742720	67742720	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgtaaacttcatggttcggCtttttgtggtgattgtgatg	12	5	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chrX:67742720C>A	uc004dwy.2	+	6	576	c.553C>A	c.(553-555)CTT>ATT	p.L185I	YIPF6_uc011mph.1_Missense_Mutation_p.L142I	NM_173834	NP_776195	Q96EC8	YIPF6_HUMAN	Yip1 domain family, member 6	185	Helical; (Potential).					endoplasmic reticulum|integral to membrane					0						CATGGTTCGGCTTTTTGTGGT	0.408													A	67742720	A	A	67742720	3	1	123	1	0	0	0	0	1	0	0	0	17479	797	28	5	575	5	YIPF6	23	67742720	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	12092407	67742720	87527840	89	8530											
FAM199X	139231	broad.mit.edu	37	chrX	103434406	103434406	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccttaacgaagaggtgctgTccttgaaagtgactgaggaa	12	7	0	4			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chrX:103434406T>C	uc004elw.2	+	6	1280	c.1114T>C	c.(1114-1116)TCC>CCC	p.S372P	FAM199X_uc004elx.2_Missense_Mutation_p.S146P	NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	372										ovary(1)	1						AGAGGTGCTGTCCTTGAAAGT	0.473													C	103434406	C	C	103434406	3	2	123	1	0	0	0	0	1	0	0	0	5530	1667	58	4	1136	4	FAM199X	23	103434406	Missense_Mutation	SNP	T	TCGA-12-5295-01A-01D-1486-08	35691686	103434406	51836154	90	8531											
COL4A5	1287	broad.mit.edu	37	chrX	107911614	107911614	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gccttccaggtccaaagggcGaaccaggctttcacggtttc	11	13	1	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chrX:107911614G>A	uc004enz.1	+	41	3872	c.3670G>A	c.(3670-3672)GAA>AAA	p.E1224K	COL4A5_uc011mso.1_Missense_Mutation_p.E1224K	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1224	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						TCCAAAGGGCGAACCAGGCTT	0.532									Alport_syndrome_with_Diffuse_Leiomyomatosis				A	107911614	A	A	107911614	3	1	123	1	0	0	0	0	1	0	0	0	3694	1059	37	2	3832	2	COL4A5	23	107911614	Missense_Mutation	SNP	G	TCGA-12-5295-01A-01D-1486-08	4477208	107911614	47358946	91	8532											
ZNF275	10838	broad.mit.edu	37	chrX	152613030	152613030	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccaagccatacgggtgtcCccactgcggcaagctcttcc	11	16	1	0			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chrX:152613030C>T	uc004fhg.1	+	4	1064	c.887C>T	c.(886-888)CCC>CTC	p.P296L	ZNF275_uc011mym.1_Missense_Mutation_p.P296L|ZNF275_uc011myn.1_Missense_Mutation_p.P233L			A6NFS0	A6NFS0_HUMAN	SubName: Full=cDNA FLJ16723 fis, clone UTERU3004418, highly similar to Zinc finger protein 275; SubName: Full=Putative uncharacterized protein ZNF275;	296						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TACGGGTGTCCCCACTGCGGC	0.682													T	152613030	T	T	152613030	3	4	123	1	0	0	0	0	1	0	0	0	17807	623	22	3	897	3	ZNF275	23	152613030	Missense_Mutation	SNP	C	TCGA-12-5295-01A-01D-1486-08	44701416	152613030	2657530	92	8533											
SLC10A3	8273	broad.mit.edu	37	chrX	153716308	153716308	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcaatgaacagcagggtcccCaggatcttggagatgggcac	14	10	1	2			TCGA-12-5295-01A-01D-1486-08	TCGA-12-5295-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	796f5741-3b2d-46e5-b74f-e5a76604a401	acb44b8b-11f0-4e02-bc40-f96205ac66f9	g.chrX:153716308C>A	uc004flq.2	-	3	1236	c.972G>T	c.(970-972)CTG>CTT	p.L324L	UBL4A_uc004flo.2_5'Flank|SLC10A3_uc004flr.2_Silent_p.L295L|SLC10A3_uc004flp.2_Silent_p.L324L	NM_001142392	NP_001135864	P09131	P3_HUMAN	solute carrier family 10, member 3 isoform 1	324	Helical; (Potential).				organic anion transport	integral to membrane	bile acid:sodium symporter activity			ovary(1)|skin(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCAGGGTCCCCAGGATCTTGG	0.607													A	153716308	A	A	153716308	2	1	123	1	0	0	0	0	0	0	0	1	14375	581	21	5		5	SLC10A3	23	153716308	Silent	SNP	C	TCGA-12-5295-01A-01D-1486-08	1103278	153716308	1554252	93	8534											
FAM131C	348487	broad.mit.edu	37	chr1	16390042	16390042	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgacacagtctggagccaCggtgggagtgcggcccgagg	17	10	1	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr1:16390042C>T	uc001axz.3	-	2	302	c.112G>A	c.(112-114)GTG>ATG	p.V38M	FAM131C_uc010obz.1_Missense_Mutation_p.V38M	NM_182623	NP_872429	Q96AQ9	F131C_HUMAN	hypothetical protein LOC348487	38											0		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.32e-08)|COAD - Colon adenocarcinoma(227;5.56e-06)|BRCA - Breast invasive adenocarcinoma(304;9.12e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00656)|READ - Rectum adenocarcinoma(331;0.0649)		TCTGGAGCCACGGTGGGAGTG	0.632													T	16390042	T	T	16390042	3	4	124	1	0	0	0	0	1	0	0	0	5441	536	19	1	754	1	FAM131C	1	16390042	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08		16390042	232860579	1	8535											
RCAN3	11123	broad.mit.edu	37	chr1	24857822	24857822	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgaagcggcagcaagagcgCgaatagaactccacgaaaca	11	11	0	3			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr1:24857822C>T	uc001bjj.2	+	3	623	c.310C>T	c.(310-312)CGA>TGA	p.R104*	RCAN3_uc009vrd.2_Nonsense_Mutation_p.R104*|RCAN3_uc009vre.2_Intron|RCAN3_uc009vrf.2_Nonsense_Mutation_p.R104*|RCAN3_uc009vrg.2_Intron	NM_013441	NP_038469	Q9UKA8	RCAN3_HUMAN	Down syndrome critical region gene 1-like 2	104					anatomical structure morphogenesis|calcium-mediated signaling		nucleotide binding|RNA binding|troponin I binding				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00473)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0427)|OV - Ovarian serous cystadenocarcinoma(117;1.13e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;0.000923)|BRCA - Breast invasive adenocarcinoma(304;0.0018)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.00493)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.14)		AGCAAGAGCGCGAATAGAACT	0.413													T	24857822	T	T	24857822	4	4	124	1	0	0	0	0	0	1	0	0	13170	760	27	1	316	1	RCAN3	1	24857822	Nonsense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08	8467780	24857822	224392799	2	8536											
GRIK3	2899	broad.mit.edu	37	chr1	37285426	37285426	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cggagccagggttgcaggggTgagcatcgtaccactcataa	14	10	1	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr1:37285426T>C	uc001caz.2	-	12	1919	c.1784A>G	c.(1783-1785)CAC>CGC	p.H595R	GRIK3_uc001cba.1_Missense_Mutation_p.H595R	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	595	Cytoplasmic (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GTTGCAGGGGTGAGCATCGTA	0.562													C	37285426	C	C	37285426	3	2	124	1	0	0	0	0	1	0	0	0	6775	1696	59	4	995	4	GRIK3	1	37285426	Missense_Mutation	SNP	T	TCGA-12-5299-01A-02D-1486-08	12427604	37285426	211965195	3	8537											
SLC44A5	204962	broad.mit.edu	37	chr1	75679448	75679448	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cttgtgcaatcactggcagtCtttgtgtgaagaataggaag	12	6	2	2			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr1:75679448C>G	uc001dgu.2	-	22	2048	c.1904G>C	c.(1903-1905)AGA>ACA	p.R635T	SLC44A5_uc001dgt.2_Missense_Mutation_p.R635T|SLC44A5_uc001dgs.2_Missense_Mutation_p.R593T|SLC44A5_uc001dgr.2_Missense_Mutation_p.R593T|SLC44A5_uc010oqz.1_Missense_Mutation_p.R674T|SLC44A5_uc010ora.1_Missense_Mutation_p.R629T|SLC44A5_uc010orb.1_Missense_Mutation_p.R505T	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	635	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						CACTGGCAGTCTTTGTGTGAA	0.318													G	75679448	G	G	75679448	3	3	124	1	0	0	0	0	1	0	0	0	14639	913	32	5	378	5	SLC44A5	1	75679448	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08	38394022	75679448	173571173	4	8538											
HRNR	388697	broad.mit.edu	37	chr1	152187697	152187697	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gactgtcctgatctagagccGtgttgtccgtagccagagga	13	10	1	3			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr1:152187697G>A	uc001ezt.1	-	3	6484	c.6408C>T	c.(6406-6408)CAC>CAT	p.H2136H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2136					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCTAGAGCCGTGTTGTCCGT	0.557													A	152187697	A	A	152187697	2	1	124	1	0	0	0	0	0	0	0	1	7359	1136	40	1		1	HRNR	1	152187697	Silent	SNP	G	TCGA-12-5299-01A-02D-1486-08	76508249	152187697	97062924	5	8539											
GOLT1A	127845	broad.mit.edu	37	chr1	204170871	204170871	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggttcccttgagtttgtgCcgttggaagaagaaccaaaa	11	8	0	3			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr1:204170871C>T	uc001has.1	-	3	372	c.186G>A	c.(184-186)CGG>CGA	p.R62R	GOLT1A_uc001hat.1_Silent_p.R62R	NM_198447	NP_940849	Q6ZVE7	GOT1A_HUMAN	golgi transport 1 homolog A	62	Cytoplasmic (Potential).				protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane					0	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			TGAGTTTGTGCCGTTGGAAGA	0.567													T	204170871	T	T	204170871	2	4	124	1	0	0	0	0	0	0	0	1	6570	726	26	3		3	GOLT1A	1	204170871	Silent	SNP	C	TCGA-12-5299-01A-02D-1486-08	51983174	204170871	45079750	6	8540											
NID1	4811	broad.mit.edu	37	chr1	236189279	236189279	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggacgaacacgctgtccaccGagagctgctgggtgctgggc	16	12	0	1	rs147220938		TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr1:236189279G>A	uc001hxo.2	-	8	2003	c.1901C>T	c.(1900-1902)TCG>TTG	p.S634L	NID1_uc009xgd.2_Missense_Mutation_p.S634L	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	634	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCTGTCCACCGAGAGCTGCTG	0.592													A	236189279	A	A	236189279	3	1	124	1	0	0	0	0	1	0	0	0	10414	1059	37	2	1894	2	NID1	1	236189279	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08	32018408	236189279	13061342	7	8541											
ZNF513	130557	broad.mit.edu	37	chr2	27600813	27600813	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcttctctcctgtatggaCgcgctggtgccgtttcaggt	14	11	2	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr2:27600813C>T	uc002rkk.2	-	4	1425	c.1225G>A	c.(1225-1227)GTC>ATC	p.V409I	ZNF513_uc002rkj.2_Missense_Mutation_p.V347I	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	409	C2H2-type 5.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTGTATGGACGCGCTGGTGC	0.587													T	27600813	T	T	27600813	3	4	124	1	0	0	0	0	1	0	0	0	17955	536	19	1	404	1	ZNF513	2	27600813	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08		27600813	215598560	8	8542											
IL1R1	3554	broad.mit.edu	37	chr2	102791960	102791960	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagatggaaagacctatgaCgcatatatactgtatccaaa	7	8	1	3	rs113665542	byFrequency	TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr2:102791960C>T	uc002tbq.2	+	11	1476	c.1158C>T	c.(1156-1158)GAC>GAT	p.D386D	IL1R1_uc010fix.2_Intron|IL1R1_uc002tbp.2_Silent_p.D386D|IL1R1_uc002tbr.2_Silent_p.D386D	NM_000877	NP_000868	P14778	IL1R1_HUMAN	interleukin 1 receptor, type I precursor	386	TIR.|Cytoplasmic (Potential).				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			skin(1)	1					Anakinra(DB00026)	AGACCTATGACGCATATATAC	0.363													T	102791960	T	T	102791960	2	4	124	1	0	0	0	0	0	0	0	1	7658	535	19	1		1	IL1R1	2	102791960	Silent	SNP	C	TCGA-12-5299-01A-02D-1486-08	75191147	102791960	140407413	9	8543											
ANKAR	150709	broad.mit.edu	37	chr2	190603404	190603404	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cagacttctactattgtcttGacaggtaagaaatgactaga	8	7	2	5			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr2:190603404G>A	uc002uqw.1	+	18	3483	c.3483G>A	c.(3481-3483)TTG>TTA	p.L1161L	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqx.1_RNA|ANKAR_uc002uqy.1_Silent_p.L328L	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1232						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			CTATTGTCTTGACAGGTAAGA	0.294													A	190603404	A	A	190603404	2	1	124	1	0	0	0	0	0	0	0	1	623	1281	45	3		3	ANKAR	2	190603404	Silent	SNP	G	TCGA-12-5299-01A-02D-1486-08	87811444	190603404	52595969	10	8544											
ITPR1	3708	broad.mit.edu	37	chr3	4669476	4669476	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttaagctatgtcccatgaacCgctactctgcccaaaagcag	7	13	1	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr3:4669476C>T	uc003bqa.2	+	5	541	c.193C>T	c.(193-195)CGC>TGC	p.R65C	ITPR1_uc010hbz.2_Missense_Mutation_p.R65C|ITPR1_uc010hca.1_Missense_Mutation_p.R65C|ITPR1_uc011asu.1_Missense_Mutation_p.R65C|ITPR1_uc010hcb.1_Missense_Mutation_p.R65C	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	65	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TCCCATGAACCGCTACTCTGC	0.468													T	4669476	T	T	4669476	3	4	124	1	0	0	0	0	1	0	0	0	7920	652	23	2	203	2	ITPR1	3	4669476	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08		4669476	193352954	11	8545											
CHST2	9435	broad.mit.edu	37	chr3	142840212	142840212	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttcttcggcgagctattcaAccagaatcccgaggtgttct	10	11	3	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr3:142840212A>G	uc003evm.2	+	2	1443	c.554A>G	c.(553-555)AAC>AGC	p.N185S		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	185	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						GAGCTATTCAACCAGAATCCC	0.622													G	142840212	G	G	142840212	3	3	124	1	0	0	0	0	1	0	0	0	3404	43	2	4	556	4	CHST2	3	142840212	Missense_Mutation	SNP	A	TCGA-12-5299-01A-02D-1486-08	138170736	142840212	55182218	12	8546											
SH3RF1	57630	broad.mit.edu	37	chr4	170190261	170190261	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tacgatccccagcaaacatcGcttgcaaaacgtatgctggc	8	13	0	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr4:170190261G>C	uc003isa.1	-	2	438	c.103C>G	c.(103-105)CGA>GGA	p.R35G		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	35	RING-type.					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		AGCAAACATCGCTTGCAAAAC	0.517													C	170190261	C	C	170190261	3	2	124	1	0	0	0	0	1	0	0	0	14258	1095	38	5	2607	5	SH3RF1	4	170190261	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08		170190261	20964015	13	8547											
PCDHA3	56145	broad.mit.edu	37	chr5	140181796	140181796	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatcactgcacagttctactCgaaattgtggacatcaatga	8	9	3	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr5:140181796C>T	uc003lhf.2	+	1	1014	c.1014C>T	c.(1012-1014)CTC>CTT	p.L338L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.L338L	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	338	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTTCTACTCGAAATTGTGG	0.398													T	140181796	T	T	140181796	2	4	124	1	0	0	0	0	0	0	0	1	11525	871	31	2		2	PCDHA3	5	140181796	Silent	SNP	C	TCGA-12-5299-01A-02D-1486-08		140181796	40733464	14	8548											
PCDHGB2	56103	broad.mit.edu	37	chr5	140741377	140741377	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggcgacctcaatgacaatGcgccacgggtgctgtacccc	12	14	1	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr5:140741377G>A	uc003ljs.1	+	1	1675	c.1675G>A	c.(1675-1677)GCG>ACG	p.A559T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.A559T|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	559	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATGACAATGCGCCACGGGT	0.692													A	140741377	A	A	140741377	3	1	124	1	0	0	0	0	1	0	0	0	11563	1319	46	3	1677	3	PCDHGB2	5	140741377	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08	559581	140741377	40173883	15	8549											
EIF4E1B	253314	broad.mit.edu	37	chr5	176070180	176070180	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aggagaaaagtctccaaactCtcccaggactttgctgtctc	8	12	3	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr5:176070180C>G	uc010jkf.1	+	4	697	c.113C>G	c.(112-114)TCT>TGT	p.S38C		NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	38					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTCCAAACTCTCCCAGGACT	0.453													G	176070180	G	G	176070180	3	3	124	1	0	0	0	0	1	0	0	0	5029	913	32	5	119	5	EIF4E1B	5	176070180	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08	35328803	176070180	4845080	16	8550											
SLC17A2	10246	broad.mit.edu	37	chr6	25917030	25917030	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atggcccaaagtggtaggcaTgtgaccatcgcctttatggg	13	9	0	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr6:25917030T>A	uc011dkb.1	-	7	896	c.813A>T	c.(811-813)ACA>ACT	p.T271T	SLC17A2_uc011dkc.1_Silent_p.T271T|SLC17A2_uc003nfl.2_Silent_p.T271T			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	271					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						GTGGTAGGCATGTGACCATCG	0.478													A	25917030	A	A	25917030	2	1	124	1	0	0	0	0	0	0	0	1	14417	1451	51	5		5	SLC17A2	6	25917030	Silent	SNP	T	TCGA-12-5299-01A-02D-1486-08		25917030	145198037	17	8551											
DNAH8	1769	broad.mit.edu	37	chr6	38834386	38834386	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaccctggatatgctgggcGccaggaactaccagaaaacc	11	12	0	1	rs139579198		TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr6:38834386G>A	uc003ooe.1	+	44	6467	c.5867G>A	c.(5866-5868)CGC>CAC	p.R1956H		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TATGCTGGGCGCCAGGAACTA	0.323													A	38834386	A	A	38834386	3	1	124	1	0	0	0	0	1	0	0	0	4607	1087	38	1	6033	1	DNAH8	6	38834386	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08	12917356	38834386	132280681	18	8552											
SDK1	221935	broad.mit.edu	37	chr7	4116751	4116751	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaccacctacaccatcgaCgtggccgctgtgactgccgt	9	17	1	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr7:4116751C>T	uc003smx.2	+	21	3271	c.3132C>T	c.(3130-3132)GAC>GAT	p.D1044D	SDK1_uc010kso.2_Silent_p.D320D	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1044	Fibronectin type-III 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACACCATCGACGTGGCCGCTG	0.587													T	4116751	T	T	4116751	2	4	124	1	0	0	0	0	0	0	0	1	13968	535	19	1		1	SDK1	7	4116751	Silent	SNP	C	TCGA-12-5299-01A-02D-1486-08		4116751	155021912	19	8553											
RHBDD2	57414	broad.mit.edu	37	chr7	75517607	75517607	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctggcacggtgtattctggGgccttgggcacaccaggggc	16	12	1	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr7:75517607G>T	uc003udw.1	+	4	1119	c.1035G>T	c.(1033-1035)GGG>GGT	p.G345G	RHBDD2_uc003udv.1_Silent_p.G204G	NM_001040456	NP_001035546	Q6NTF9	RHBD2_HUMAN	rhomboid domain containing 2 isoform a	345						integral to membrane	serine-type endopeptidase activity				0						TGTATTCTGGGGCCTTGGGCA	0.622													T	75517607	T	T	75517607	2	4	124	1	0	0	0	0	0	0	0	1	13317	1219	43	5		5	RHBDD2	7	75517607	Silent	SNP	G	TCGA-12-5299-01A-02D-1486-08	71400856	75517607	83621056	20	8554											
KCNH2	3757	broad.mit.edu	37	chr7	150649546	150649546	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagccgaagatgagcaggtcGaaggggatggcggccaccat	17	9	0	2			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr7:150649546G>A	uc003wic.2	-	6	1537	c.1524C>T	c.(1522-1524)TTC>TTT	p.F508F	KCNH2_uc003wib.2_Silent_p.F168F|KCNH2_uc011kux.1_Silent_p.F412F|KCNH2_uc003wid.2_Silent_p.F168F|KCNH2_uc003wie.2_Silent_p.F508F	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	508	Helical; Name=Segment S3; (Potential).		Missing (in LQT2).		blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TGAGCAGGTCGAAGGGGATGG	0.627													A	150649546	A	A	150649546	2	1	124	1	0	0	0	0	0	0	0	1	8032	1049	37	2		2	KCNH2	7	150649546	Silent	SNP	G	TCGA-12-5299-01A-02D-1486-08	75131939	150649546	8489117	21	8555											
EPPK1	83481	broad.mit.edu	37	chr8	144941723	144941723	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagggcaccgtgacccccGcaatgcagccgctgccttcc	12	17	0	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr8:144941723G>A	uc003zaa.1	-	1	5712	c.5699C>T	c.(5698-5700)GCG>GTG	p.A1900V		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1900	Plectin 31.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGTGACCCCCGCAATGCAGCC	0.632													A	144941723	A	A	144941723	3	1	124	1	0	0	0	0	1	0	0	0	5190	1087	38	1	1567	1	EPPK1	8	144941723	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08		144941723	1422299	22	8556											
PTPRD	5789	broad.mit.edu	37	chr9	8492897	8492897	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaccagtttgggcttgctgCgagcaccatctcctttggtt	10	12	1	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr9:8492897C>T	uc003zkk.2	-	26	3143	c.2432G>A	c.(2431-2433)CGC>CAC	p.R811H	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.R802H|PTPRD_uc003zkm.2_Missense_Mutation_p.R798H|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	811	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGGCTTGCTGCGAGCACCATC	0.463										TSP Lung(15;0.13)			T	8492897	T	T	8492897	3	4	124	1	0	0	0	0	1	0	0	0	12799	768	27	1	3454	1	PTPRD	9	8492897	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08		8492897	132720534	23	8557											
KCNT1	57582	broad.mit.edu	37	chr9	138676650	138676650	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggatccgcacgtacggccGcctcttccagaagctctgct	11	15	2	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr9:138676650G>A	uc011mdq.1	+	27	3145	c.3071G>A	c.(3070-3072)CGC>CAC	p.R1024H	KCNT1_uc011mdr.1_Missense_Mutation_p.R851H|KCNT1_uc010nbf.2_Missense_Mutation_p.R979H|KCNT1_uc004cgo.1_Missense_Mutation_p.R773H	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	1024						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		ACGTACGGCCGCCTCTTCCAG	0.637													A	138676650	A	A	138676650	3	1	124	1	0	0	0	0	1	0	0	0	8091	1087	38	1	3177	1	KCNT1	9	138676650	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08	130183753	138676650	2536781	24	8558											
OPN4	94233	broad.mit.edu	37	chr10	88418396	88418396	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggcatttgtcctgctgggcGtttggctctatgccctggcc	13	13	1	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr10:88418396G>A	uc001kdq.2	+	4	807	c.580G>A	c.(580-582)GTT>ATT	p.V194I	OPN4_uc001kdp.2_Missense_Mutation_p.V205I|OPN4_uc010qmk.1_Missense_Mutation_p.V205I|OPN4_uc009xsx.1_5'Flank	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	194	Helical; Name=4; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						CCTGCTGGGCGTTTGGCTCTA	0.647													A	88418396	A	A	88418396	3	1	124	1	0	0	0	0	1	0	0	0	10882	1145	40	1	631	1	OPN4	10	88418396	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08		88418396	47116351	25	8559											
SCUBE2	57758	broad.mit.edu	37	chr11	9074727	9074727	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgcagtgcagggacacacGgggtgacacacttgtgggca	15	11	0	1	rs77907325		TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr11:9074727G>A	uc001mhh.1	-	12	1446	c.1366C>T	c.(1366-1368)CGT>TGT	p.R456C	SCUBE2_uc001mhi.1_Missense_Mutation_p.R456C|SCUBE2_uc001mhj.1_Intron	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	456						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		AGGGACACACGGGGTGACACA	0.537													A	9074727	A	A	9074727	3	1	124	1	0	0	0	0	1	0	0	0	13945	1116	39	2	1768	2	SCUBE2	11	9074727	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08		9074727	125931789	26	8560											
TMPRSS4	56649	broad.mit.edu	37	chr11	117985881	117985881	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgacatactgctgcaggcGtcagtccaggtcattgacag	11	11	3	2			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr11:117985881G>A	uc010rxo.1	+	11	1329	c.1038G>A	c.(1036-1038)GCG>GCA	p.A346A	TMPRSS4_uc010rxp.1_Silent_p.A341A|TMPRSS4_uc010rxq.1_Silent_p.A199A|TMPRSS4_uc010rxr.1_Silent_p.A321A|TMPRSS4_uc010rxs.1_Silent_p.A306A|TMPRSS4_uc009yzu.2_Intron|TMPRSS4_uc010rxt.1_Silent_p.A321A	NM_019894	NP_063947	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4 isoform 1	346	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		TGCTGCAGGCGTCAGTCCAGG	0.552													A	117985881	A	A	117985881	2	1	124	1	0	0	0	0	0	0	0	1	16246	1132	40	1		1	TMPRSS4	11	117985881	Silent	SNP	G	TCGA-12-5299-01A-02D-1486-08	108911154	117985881	17020635	27	8561											
MFRP	83552	broad.mit.edu	37	chr11	119216274	119216274	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gccacacgcagtgggtgttgGgggggtaagggtctgggtag	21	6	1	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr11:119216274G>C	uc001pwj.2	-	5	657	c.497C>G	c.(496-498)CCC>CGC	p.P166R	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Missense_Mutation_p.P166R	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	117	C1q.					collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		GTGGGTGTTGGGGGGGTAAGG	0.567													C	119216274	C	C	119216274	3	2	124	1	0	0	0	0	1	0	0	0	9526	1232	43	5	1278	5	MFRP	11	119216274	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08	1230393	119216274	15790242	28	8562											
POU2F3	25833	broad.mit.edu	37	chr11	120168973	120168973	+	Splice_Site	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tcctcttgcttccacttgcaGattaaaaccgaagatctcag	6	12	2	2			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr11:120168973G>C	uc001pxc.2	+	4	235	c.133_splice	c.e4-1	p.I45_splice	POU2F3_uc010rzk.1_Splice_Site|POU2F3_uc010rzl.1_Splice_Site	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor						negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		TCCACTTGCAGATTAAAACCG	0.547													C	120168973	C	C	120168973	5	2	124	1	0	0	0	0	0	0	1	0	12273	956	33	5	146	5	POU2F3	11	120168973	Splice_Site	SNP	G	TCGA-12-5299-01A-02D-1486-08	952699	120168973	14837543	29	8563											
ZNF202	7753	broad.mit.edu	37	chr11	123600382	123600382	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gacgctgctctgccggtgccCccagatctgggctctgtgtg	14	14	3	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr11:123600382C>A	uc001pzd.1	-	5	954	c.554G>T	c.(553-555)GGG>GTG	p.G185V	ZNF202_uc001pzc.1_5'UTR|ZNF202_uc001pze.1_Missense_Mutation_p.G185V|ZNF202_uc001pzf.1_Missense_Mutation_p.G185V	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	185					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TGCCGGTGCCCCCAGATCTGG	0.607													A	123600382	A	A	123600382	3	1	124	1	0	0	0	0	1	0	0	0	17760	623	22	5	1412	5	ZNF202	11	123600382	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08	3431409	123600382	11406134	30	8564											
ACAD8	27034	broad.mit.edu	37	chr11	134128470	134128470	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaggcacaaattttgcccaCcgctctgtaccatggagaag	10	11	1	2			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr11:134128470C>T	uc001qhk.2	+	4	503	c.442C>T	c.(442-444)CCG>TCG	p.P148S	ACAD8_uc009zdc.2_Missense_Mutation_p.P50S|ACAD8_uc010sco.1_Missense_Mutation_p.P50S|ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.P71S|ACAD8_uc001qhl.2_Intron|ACAD8_uc010scr.1_Missense_Mutation_p.P110S|ACAD8_uc009zde.1_Missense_Mutation_p.P21S	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	148					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		ATTTTGCCCACCGCTCTGTAC	0.433													T	134128470	T	T	134128470	3	4	124	1	0	0	0	0	1	0	0	0	110	507	18	3	456	3	ACAD8	11	134128470	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08	10528088	134128470	878046	31	8565											
TMEM117	84216	broad.mit.edu	37	chr12	44782427	44782427	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaagctgatcaagacccaaCgacttctaaaagtacaccta	6	11	2	3	rs150984405		TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr12:44782427C>T	uc001rod.2	+	8	1583	c.1517C>T	c.(1516-1518)ACG>ATG	p.T506M	TMEM117_uc001roe.2_Missense_Mutation_p.T402M|TMEM117_uc009zkc.2_3'UTR	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	506						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		CAAGACCCAACGACTTCTAAA	0.398													T	44782427	T	T	44782427	3	4	124	1	0	0	0	0	1	0	0	0	16028	536	19	1	1543	1	TMEM117	12	44782427	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08		44782427	89069468	32	8566											
NR2C1	7181	broad.mit.edu	37	chr12	95425195	95425195	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctacattcatcacttgccaGcactgggcaagaccaagagt	9	12	2	2			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr12:95425195G>A	uc001tdm.3	-	11	1579	c.1323C>T	c.(1321-1323)TGC>TGT	p.C441C	NR2C1_uc010suu.1_Intron|NR2C1_uc001tdo.3_Silent_p.C441C|NR2C1_uc001tdn.3_Silent_p.C441C	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	441					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1						TCACTTGCCAGCACTGGGCAA	0.368													A	95425195	A	A	95425195	2	1	124	1	0	0	0	0	0	0	0	1	10622	963	34	3		3	NR2C1	12	95425195	Silent	SNP	G	TCGA-12-5299-01A-02D-1486-08	50642768	95425195	38426700	33	8567											
VPS29	51699	broad.mit.edu	37	chr12	110929907	110929907	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagcctggatatccatcaacAcaaatgatggaataatgttt	7	7	1	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr12:110929907A>G	uc001tqy.2	-	4	512	c.452T>C	c.(451-453)GTG>GCG	p.V151A	VPS29_uc001tqw.2_RNA|VPS29_uc001tqx.2_Missense_Mutation_p.V155A|VPS29_uc001tqz.2_RNA	NM_016226	NP_057310	Q9UBQ0	VPS29_HUMAN	vacuolar protein sorting 29 isoform 1	151					protein transport	endosome membrane	metal ion binding|phosphoserine phosphatase activity				0						ATCCATCAACACAAATGATGG	0.328													G	110929907	G	G	110929907	3	3	124	1	0	0	0	0	1	0	0	0	17197	159	6	4	100	4	VPS29	12	110929907	Missense_Mutation	SNP	A	TCGA-12-5299-01A-02D-1486-08	15504712	110929907	22921988	34	8568											
KSR2	283455	broad.mit.edu	37	chr12	118198984	118198984	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatgggcggcgtgcccggcGgggtcacggtggtgacgatg	20	10	2	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr12:118198984G>A	uc001two.2	-	4	786	c.731C>T	c.(730-732)CCG>CTG	p.P244L		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	273	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGTGCCCGGCGGGGTCACGGT	0.701													A	118198984	A	A	118198984	3	1	124	1	0	0	0	0	1	0	0	0	8582	1116	39	2	2102	2	KSR2	12	118198984	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08	7269077	118198984	15652911	35	8569											
ARHGAP5	394	broad.mit.edu	37	chr14	32561686	32561686	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctttttattttagggaaggAtggccttgcccaagaactag	10	8	0	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr14:32561686A>T	uc001wrl.2	+	2	2050	c.1811A>T	c.(1810-1812)GAT>GTT	p.D604V	ARHGAP5_uc001wrm.2_Missense_Mutation_p.D604V|ARHGAP5_uc001wrn.2_Missense_Mutation_p.D604V|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	604					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTAGGGAAGGATGGCCTTGCC	0.373													T	32561686	T	T	32561686	3	4	124	1	0	0	0	0	1	0	0	0	886	333	12	5	1813	5	ARHGAP5	14	32561686	Missense_Mutation	SNP	A	TCGA-12-5299-01A-02D-1486-08		32561686	74787854	36	8570											
ITGAX	3687	broad.mit.edu	37	chr16	31384692	31384692	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccgcaggactgtcctaccGctacgtggcagagggccagg	14	15	0	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr16:31384692G>A	uc002ebu.1	+	20	2556	c.2489G>A	c.(2488-2490)CGC>CAC	p.R830H	ITGAX_uc002ebt.2_Missense_Mutation_p.R830H	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	830	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTGTCCTACCGCTACGTGGCA	0.622													A	31384692	A	A	31384692	3	1	124	1	0	0	0	0	1	0	0	0	7889	1087	38	1	2567	1	ITGAX	16	31384692	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08		31384692	58970061	37	8571											
KRT23	25984	broad.mit.edu	37	chr17	39092707	39092707	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccagggggtgggcagctcCgcgtggtgaaggacagggag	20	9	0	1	rs148371500		TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr17:39092707C>T	uc002hvm.1	-	2	738	c.149G>A	c.(148-150)CGG>CAG	p.R50Q	KRT23_uc010wfl.1_Intron|KRT23_uc010cxf.1_Intron|KRT23_uc010cxg.2_Missense_Mutation_p.R50Q|KRT23_uc002hvn.1_Missense_Mutation_p.R50Q	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	50	Head.					intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)				TGGGCAGCTCCGCGTGGTGAA	0.692													T	39092707	T	T	39092707	3	4	124	1	0	0	0	0	1	0	0	0	8460	652	23	2	1151	2	KRT23	17	39092707	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08		39092707	42102503	38	8572											
KRTAP4-9	100132386	broad.mit.edu	37	chr17	39262036	39262036	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccccagctgctgtgtgtcCagctgctgcaagccccagtg	12	16	0	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr17:39262036C>T	uc010wfp.1	+	1	396	c.396C>T	c.(394-396)TCC>TCT	p.S132S		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	132	21.|29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament					0						gctgtgtgtccagctgctgca	0.194													T	39262036	T	T	39262036	2	4	124	1	0	0	0	0	0	0	0	1	8557	581	21	3		3	KRTAP4-9	17	39262036	Silent	SNP	C	TCGA-12-5299-01A-02D-1486-08	169329	39262036	41933174	39	8573											
DGKE	8526	broad.mit.edu	37	chr17	54940030	54940030	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atggggagccttgggcccaaGggccctgcactgtcaccata	13	13	1	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr17:54940030G>T	uc002iur.2	+	12	1762	c.1582G>T	c.(1582-1584)GGG>TGG	p.G528W	DGKE_uc002ius.1_3'UTR	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	528					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)					TTGGGCCCAAGGGCCCTGCAC	0.448													T	54940030	T	T	54940030	3	4	124	1	0	0	0	0	1	0	0	0	4468	1000	35	5	1624	5	DGKE	17	54940030	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08	15677994	54940030	26255180	40	8574											
CASKIN2	57513	broad.mit.edu	37	chr17	73498864	73498864	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gtggccctggggccgggctaGagggtgagccctgggggtac	21	10	0	2			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr17:73498864G>C	uc002joc.2	-	18	2841	c.2291C>G	c.(2290-2292)TCT>TGT	p.S764C	CASKIN2_uc010wsc.1_Missense_Mutation_p.S682C	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	764	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGCCGGGCTAGAGGGTGAGCC	0.667													C	73498864	C	C	73498864	3	2	124	1	0	0	0	0	1	0	0	0	2667	942	33	5	1329	5	CASKIN2	17	73498864	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08	18558834	73498864	7696346	41	8575											
EVPL	2125	broad.mit.edu	37	chr17	74017966	74017966	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctcgtactcccgccgcacGcccgcagggtcggccatgag	12	18	0	1			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr17:74017966G>A	uc002jqi.2	-	7	1017	c.789C>T	c.(787-789)GGC>GGT	p.G263G	EVPL_uc010wss.1_Silent_p.G263G|EVPL_uc010wst.1_5'UTR	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	263	Spectrin.|Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CCCGCCGCACGCCCGCAGGGT	0.756													A	74017966	A	A	74017966	2	1	124	1	0	0	0	0	0	0	0	1	5292	1074	38	1		1	EVPL	17	74017966	Silent	SNP	G	TCGA-12-5299-01A-02D-1486-08	519102	74017966	7177244	42	8576											
SLC25A10	1468	broad.mit.edu	37	chr17	79682531	79682531	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acctactccctgactcggttCgccatctacgagactgtgcg	9	15	1	2	rs146181618	byFrequency	TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr17:79682531C>T	uc002kbi.2	+	3	323	c.237C>T	c.(235-237)TTC>TTT	p.F79F	SLC25A10_uc010wut.1_Silent_p.F234F|SLC25A10_uc010dif.2_Silent_p.F79F|SLC25A10_uc010wuu.1_Silent_p.F33F	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	79	Solcar 1.|Helical; Name=2; (Potential).				gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	TGACTCGGTTCGCCATCTACG	0.687													T	79682531	T	T	79682531	2	4	124	1	0	0	0	0	0	0	0	1	14472	883	31	2		2	SLC25A10	17	79682531	Silent	SNP	C	TCGA-12-5299-01A-02D-1486-08	5664565	79682531	1512679	43	8577											
ADNP2	22850	broad.mit.edu	37	chr18	77896288	77896288	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ggcatggggaggagcagcctCccatcctaaatgccgatgca	13	12	0	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr18:77896288C>A	uc002lnw.2	+	4	3447	c.2992C>A	c.(2992-2994)CCC>ACC	p.P998T		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	998					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GGAGCAGCCTCCCATCCTAAA	0.517													A	77896288	A	A	77896288	3	1	124	1	0	0	0	0	1	0	0	0	324	855	30	5	3002	5	ADNP2	18	77896288	Missense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08		77896288	180960	44	8578											
ZNF358	140467	broad.mit.edu	37	chr19	7585663	7585663	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtgcccagcccagaccTtgatcctgtgcccagcccag	9	18	0	2	rs28655671		TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr19:7585663T>C	uc002mgn.2	+	2	1705	c.1535T>C	c.(1534-1536)CTT>CCT	p.L512P	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	512					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						AGCCCAGACCTTGATCCTGTG	0.537													C	7585663	C	C	7585663	3	2	124	1	0	0	0	0	1	0	0	0	17864	1609	56	4	1537	4	ZNF358	19	7585663	Missense_Mutation	SNP	T	TCGA-12-5299-01A-02D-1486-08		7585663	51543320	45	8579											
MEGF8	1954	broad.mit.edu	37	chr19	42855690	42855690	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcccggtacccacacgggGgctgtcgaggctgggacgac	17	13	0	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr19:42855690G>A	uc002otl.3	+	16	3399	c.2764G>A	c.(2764-2766)GGC>AGC	p.G922S	MEGF8_uc002otm.3_Missense_Mutation_p.G530S	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	989	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				CCCACACGGGGGCTGTCGAGG	0.662													A	42855690	A	A	42855690	3	1	124	1	0	0	0	0	1	0	0	0	9463	1232	43	3	2826	3	MEGF8	19	42855690	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08	35270027	42855690	16273293	46	8580											
DYNLRB1	83658	broad.mit.edu	37	chr20	33114101	33114101	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaggagacactgaagcgacTgcagagccagaagggagtgc	17	8	0	4			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr20:33114101T>C	uc002xal.2	+	2	92	c.32T>C	c.(31-33)CTG>CCG	p.L11P	DYNLRB1_uc010zuk.1_Missense_Mutation_p.L11P|DYNLRB1_uc002xam.2_RNA|DYNLRB1_uc002xan.2_RNA|DYNLRB1_uc002xao.2_RNA	NM_014183	NP_054902	Q9NP97	DLRB1_HUMAN	Roadblock-1	11					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity				0						CTGAAGCGACTGCAGAGCCAG	0.587													C	33114101	C	C	33114101	3	2	124	1	0	0	0	0	1	0	0	0	4850	1580	55	4	38	4	DYNLRB1	20	33114101	Missense_Mutation	SNP	T	TCGA-12-5299-01A-02D-1486-08		33114101	29911419	47	8581											
AIRE	326	broad.mit.edu	37	chr21	45706905	45706905	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggggaggaagcccccggccGtccccaaggctttggtaccg	15	14	0	0			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chr21:45706905G>A	uc002zei.2	+	3	479	c.352G>A	c.(352-354)GTC>ATC	p.V118I		NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	118					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		GCCCCCGGCCGTCCCCAAGGC	0.672									Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				A	45706905	A	A	45706905	3	1	124	1	0	0	0	0	1	0	0	0	437	1145	40	1	362	1	AIRE	21	45706905	Missense_Mutation	SNP	G	TCGA-12-5299-01A-02D-1486-08		45706905	2422990	48	8582											
ARSD	414	broad.mit.edu	37	chrX	2836003	2836003	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgaaaaacaggcagcccacGccggccatgccggtgactgc	12	14	0	2			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chrX:2836003G>A	uc004cqy.2	-	5	781	c.705C>T	c.(703-705)GGC>GGT	p.G235G	ARSD_uc004cqz.1_Intron|ARSD_uc004cra.1_Silent_p.G235G	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	235						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCAGCCCACGCCGGCCATGC	0.592													A	2836003	A	A	2836003	2	1	124	1	0	0	0	0	0	0	0	1	989	1074	38	1		1	ARSD	23	2836003	Silent	SNP	G	TCGA-12-5299-01A-02D-1486-08		2836003	152434557	49	8583											
CXorf58	254158	broad.mit.edu	37	chrX	23953460	23953460	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtgatctcaaaccgtctaCgaaatgaaatgaagtttctg	9	7	3	3			TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chrX:23953460C>T	uc004daz.1	+	7	1047	c.703C>T	c.(703-705)CGA>TGA	p.R235*	CXorf58_uc011mju.1_Nonsense_Mutation_p.R235*	NM_152761	NP_689974	Q96LI9	CX058_HUMAN	hypothetical protein LOC254158	235											0						AAACCGTCTACGAAATGAAAT	0.378													T	23953460	T	T	23953460	4	4	124	1	0	0	0	0	0	1	0	0	4114	528	19	1	725	1	CXorf58	23	23953460	Nonsense_Mutation	SNP	C	TCGA-12-5299-01A-02D-1486-08	21117457	23953460	131317100	50	8584											
ZNF182	7569	broad.mit.edu	37	chrX	47842386	47842386	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggatttttccttctgccggGcattcttctacctccaactt	7	13	3	0	rs141215624	byFrequency	TCGA-12-5299-01A-02D-1486-08	TCGA-12-5299-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	a44954fc-49f2-489a-8593-7de98963e4f8	dd77b73d-a3a8-4b16-82cb-d7225658a07d	g.chrX:47842386G>A	uc004dir.2	-	6	598	c.252C>T	c.(250-252)TGC>TGT	p.C84C	ZNF182_uc004dis.2_Silent_p.C65C|ZNF182_uc004dit.2_Silent_p.C84C|ZNF182_uc011mlu.1_Silent_p.C65C	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	84	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CTTCTGCCGGGCATTCTTCTA	0.478													A	47842386	A	A	47842386	2	1	124	1	0	0	0	0	0	0	0	1	17747	1195	42	3		3	ZNF182	23	47842386	Silent	SNP	G	TCGA-12-5299-01A-02D-1486-08	23888926	47842386	107428174	51	8585											
CAMTA1	23261	broad.mit.edu	37	chr1	7811328	7811329	+	Frame_Shift_Ins	INS	-	A	A													attccgaagttactatgaacINSaaaaaaaattccagcagagc							TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr1:7811328_7811329insA	uc001aoi.2	+	20	4966_4967	c.4759_4760insA	c.(4759-4761)CAAfs	p.Q1587fs	CAMTA1_uc001aok.3_Frame_Shift_Ins_p.Q630fs|CAMTA1_uc001aoj.2_Frame_Shift_Ins_p.Q550fs|CAMTA1_uc009vmf.2_Frame_Shift_Ins_p.Q177fs	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1587	IQ 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TTACTATGAACAAAAAAAATTC	0.47													A	7811329	A	A	7811328	7	5	125	1	0	1	1	0	0	0	0	0	2613	479	17	0	4837	0	CAMTA1	1	7811328	Frame_Shift_Ins	INS	-	TCGA-12-5301-01A-01D-1486-08		7811328	241439293	1	8586											
SPRR1B	6699	broad.mit.edu	37	chr1	153004854	153004854	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cagcagaagcagccttgcacCccaccccctcagcttcagca	7	19	2	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr1:153004854C>G	uc001fba.2	+	2	97	c.33C>G	c.(31-33)ACC>ACG	p.T11T	SPRR1B_uc009wnx.1_RNA	NM_003125	NP_003116	P22528	SPR1B_HUMAN	small proline-rich protein 1B	11	1.|2 X 12 AA approximate repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGCCTTGCACCCCACCCCCTC	0.557													G	153004854	G	G	153004854	2	3	125	1	0	0	0	0	0	0	0	1	15095	610	22	5		5	SPRR1B	1	153004854	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	145193526	153004854	96245767	2	8587											
NUP210L	91181	broad.mit.edu	37	chr1	154062058	154062058	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctggatgatttccaattcGgaatgtgagaacctttaagg	10	7	0	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr1:154062058G>A	uc001fdw.2	-	16	2272	c.2200C>T	c.(2200-2202)CGA>TGA	p.R734*	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Nonsense_Mutation_p.R734*	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	734						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TTTCCAATTCGGAATGTGAGA	0.423													A	154062058	A	A	154062058	4	1	125	1	0	0	0	0	0	1	0	0	10761	1124	39	2	3566	2	NUP210L	1	154062058	Nonsense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	1057204	154062058	95188563	3	8588											
ATP1A4	480	broad.mit.edu	37	chr1	160136448	160136448	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcaccctcacccagaaccGcatgaccgtcgcccacatgt	9	18	1	2	rs139315814		TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr1:160136448G>A	uc001fve.3	+	8	1657	c.1178G>A	c.(1177-1179)CGC>CAC	p.R393H	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_5'UTR	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	393	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACCCAGAACCGCATGACCGTC	0.577													A	160136448	A	A	160136448	3	1	125	1	0	0	0	0	1	0	0	0	1131	1087	38	1	1208	1	ATP1A4	1	160136448	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	6074390	160136448	89114173	4	8589											
SELP	6403	broad.mit.edu	37	chr1	169562857	169562857	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttacctttttgtctgaaaCgctttcttagcaaagccagg	7	9	2	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr1:169562857C>T	uc001ggi.3	-	14	2458	c.2393G>A	c.(2392-2394)CGT>CAT	p.R798H	SELP_uc001ggh.2_Intron|SELP_uc009wvr.2_Missense_Mutation_p.R797H	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	798	Cytoplasmic (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	TTGTCTGAAACGCTTTCTTAG	0.423													T	169562857	T	T	169562857	3	4	125	1	0	0	0	0	1	0	0	0	14019	536	19	1	111	1	SELP	1	169562857	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	9426409	169562857	79687764	5	8590											
FMO3	2328	broad.mit.edu	37	chr1	171080061	171080061	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagaacaatttaccgacagcCatctctgactggttgtacgt	8	10	1	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr1:171080061C>T	uc001ghi.2	+	6	861	c.750C>T	c.(748-750)GCC>GCT	p.A250A	FMO3_uc001ghh.2_Silent_p.A250A|FMO3_uc010pmb.1_Silent_p.A230A|FMO3_uc010pmc.1_Silent_p.A187A	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	250					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TACCGACAGCCATCTCTGACT	0.468													T	171080061	T	T	171080061	2	4	125	1	0	0	0	0	0	0	0	1	5956	581	21	3		3	FMO3	1	171080061	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	1517204	171080061	78170560	6	8591											
TNN	63923	broad.mit.edu	37	chr1	175067712	175067712	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccaggagagcaagaaggcCgacaccaaggcccagacagg	14	12	0	3	rs150075962	by1000genomes	TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr1:175067712C>T	uc001gkl.1	+	9	2213	c.2100C>T	c.(2098-2100)GCC>GCT	p.A700A	TNN_uc010pmx.1_Silent_p.A611A	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	700	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCAAGAAGGCCGACACCAAGG	0.572													T	175067712	T	T	175067712	2	4	125	1	0	0	0	0	0	0	0	1	16320	639	23	2		2	TNN	1	175067712	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	3987651	175067712	74182909	7	8592											
OR2T11	127077	broad.mit.edu	37	chr1	248790297	248790297	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcgagagtccacctgaatcaAgaatatcatgaccaaatttg	8	9	2	4			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr1:248790297A>G	uc001ier.1	-	1	133	c.133T>C	c.(133-135)TTG>CTG	p.L45L		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTGAATCAAGAATATCATG	0.502													G	248790297	G	G	248790297	2	3	125	1	0	0	0	0	0	0	0	1	11018	69	3	4		4	OR2T11	1	248790297	Silent	SNP	A	TCGA-12-5301-01A-01D-1486-08	73722585	248790297	460324	8	8593											
THADA	63892	broad.mit.edu	37	chr2	43768396	43768396	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaagcaacttccttcatacTtctccaacaacataccagca	2	14	2	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr2:43768396T>G	uc002rsw.3	-	21	3518	c.3166A>C	c.(3166-3168)AGT>CGT	p.S1056R	THADA_uc010far.2_Missense_Mutation_p.S325R|THADA_uc002rsx.3_Missense_Mutation_p.S1056R|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Missense_Mutation_p.S765R|THADA_uc010fat.1_Missense_Mutation_p.S203R|THADA_uc002rta.2_Missense_Mutation_p.S766R	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1056							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TCCTTCATACTTCTCCAACAA	0.418													G	43768396	G	G	43768396	3	3	125	1	0	0	0	0	1	0	0	0	15837	1609	56	5	2767	5	THADA	2	43768396	Missense_Mutation	SNP	T	TCGA-12-5301-01A-01D-1486-08		43768396	199430977	9	8594											
SLC9A4	389015	broad.mit.edu	37	chr2	103095704	103095704	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgaggaagcgcgcgtgaaCgagcagctctacatgatgat	13	8	1	4	rs115868705	byFrequency	TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr2:103095704C>T	uc002tbz.3	+	2	1120	c.663C>T	c.(661-663)AAC>AAT	p.N221N		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	221	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CGCGCGTGAACGAGCAGCTCT	0.612													T	103095704	T	T	103095704	2	4	125	1	0	0	0	0	0	0	0	1	14716	535	19	1		1	SLC9A4	2	103095704	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	59327308	103095704	140103669	10	8595											
VIL1	7429	broad.mit.edu	37	chr2	219295468	219295468	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aacttcatcaaagccaagcaGtacccaccaagcacacaggt	6	14	2	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr2:219295468G>C	uc002via.2	+	10	1034	c.969G>C	c.(967-969)CAG>CAC	p.Q323H	VIL1_uc010zke.1_Missense_Mutation_p.Q12H|VIL1_uc002vib.2_Missense_Mutation_p.Q323H|VIL1_uc002vic.1_Missense_Mutation_p.Q323H	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	323	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGCCAAGCAGTACCCACCAA	0.557													C	219295468	C	C	219295468	3	2	125	1	0	0	0	0	1	0	0	0	17161	1020	36	5	1003	5	VIL1	2	219295468	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	116199764	219295468	23903905	11	8596											
FGD5	152273	broad.mit.edu	37	chr3	14861427	14861427	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagggatgtgaagaggccacGggtgtcacaggtggggaaca	19	6	1	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:14861427G>A	uc003bzc.2	+	1	959	c.849G>A	c.(847-849)ACG>ACA	p.T283T	FGD5_uc011avk.1_Silent_p.T283T	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	283	Glu-rich.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						AAGAGGCCACGGGTGTCACAG	0.607													A	14861427	A	A	14861427	2	1	125	1	0	0	0	0	0	0	0	1	5836	1103	39	2		2	FGD5	3	14861427	Silent	SNP	G	TCGA-12-5301-01A-01D-1486-08		14861427	183161003	12	8597											
TRANK1	9881	broad.mit.edu	37	chr3	36874402	36874402	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	attgccaccaagttcattttCgactgaactaaacacttggc	6	11	1	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:36874402C>T	uc003cgj.2	-	12	5192	c.4890G>A	c.(4888-4890)TCG>TCA	p.S1630S		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2180					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AGTTCATTTTCGACTGAACTA	0.378													T	36874402	T	T	36874402	2	4	125	1	0	0	0	0	0	0	0	1	16451	871	31	2		2	TRANK1	3	36874402	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	22012975	36874402	161148028	13	8598											
ZNF167	55888	broad.mit.edu	37	chr3	44611913	44611913	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaacccacacaggggaaaaAccctatgaatgcagtgagtg	11	9	0	3			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:44611913A>C	uc010hin.2	+	6	1699	c.1311A>C	c.(1309-1311)AAA>AAC	p.K437N	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Missense_Mutation_p.K286N|ZNF167_uc003cnj.2_Missense_Mutation_p.K437N|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	437					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		CAGGGGAAAAACCCTATGAAT	0.473													C	44611913	C	C	44611913	3	2	125	1	0	0	0	0	1	0	0	0	17738	40	2	5	1329	5	ZNF167	3	44611913	Missense_Mutation	SNP	A	TCGA-12-5301-01A-01D-1486-08	7737511	44611913	153410517	14	8599											
AMT	275	broad.mit.edu	37	chr3	49455400	49455400	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtccatagcagctcggcggCgcttccctggagaatgacac	12	13	0	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:49455400C>T	uc003cww.2	-	8	1013	c.884G>A	c.(883-885)CGC>CAC	p.R295H	AMT_uc011bcn.1_Intron|AMT_uc003cwx.2_Missense_Mutation_p.R295H|AMT_uc011bco.1_Missense_Mutation_p.R251H|AMT_uc003cwy.2_Missense_Mutation_p.R247H|AMT_uc011bcp.1_Missense_Mutation_p.R198H|AMT_uc011bcq.1_Missense_Mutation_p.R239H	NM_000481	NP_000472	P48728	GCST_HUMAN	aminomethyltransferase isoform 1 precursor	295					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	AGCTCGGCGGCGCTTCCCTGG	0.582													T	49455400	T	T	49455400	3	4	125	1	0	0	0	0	1	0	0	0	589	768	27	1	363	1	AMT	3	49455400	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	4843487	49455400	148567030	15	8600											
CACNA1D	776	broad.mit.edu	37	chr3	53531323	53531323	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctgcccaaactatgagcaCctctgcacccccacctgtag	8	17	1	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:53531323C>T	uc003dgv.3	+	2	375	c.212C>T	c.(211-213)ACC>ATC	p.T71I	CACNA1D_uc003dgu.3_Missense_Mutation_p.T71I|CACNA1D_uc003dgy.3_Missense_Mutation_p.T71I	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	71	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ACTATGAGCACCTCTGCACCC	0.542													T	53531323	T	T	53531323	3	4	125	1	0	0	0	0	1	0	0	0	2541	507	18	3	218	3	CACNA1D	3	53531323	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	4075923	53531323	144491107	16	8601											
GCET2	257144	broad.mit.edu	37	chr3	111846908	111846908	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcgatatggtgatcccagcaTctaaaatacccaagagagat	9	9	1	3			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:111846908T>C	uc003dys.1	-	3	249	c.99A>G	c.(97-99)AGA>AGG	p.R33R	C3orf52_uc011bht.1_Intron|C3orf52_uc003dyr.1_Intron|GCET2_uc003dyt.1_5'UTR	NM_152785	NP_689998	Q8N6F7	GCET2_HUMAN	germinal center expressed transcript 2 isoform	33						mitochondrion					0						GATCCCAGCATCTAAAATACC	0.408													C	111846908	C	C	111846908	2	2	125	1	0	0	0	0	0	0	0	1	6288	1449	50	4		4	GCET2	3	111846908	Silent	SNP	T	TCGA-12-5301-01A-01D-1486-08	58315585	111846908	86175522	17	8602											
SLC9A10	285335	broad.mit.edu	37	chr3	111898484	111898484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatagtctgtgtcaattatcGgaaaatctttctcctttgac	6	8	4	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:111898484G>A	uc003dyu.2	-	23	3035	c.2813C>T	c.(2812-2814)CCG>CTG	p.P938L	SLC9A10_uc011bhu.1_Missense_Mutation_p.P201L|SLC9A10_uc010hqc.2_Missense_Mutation_p.P890L	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	938	cNMP.				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						GTCAATTATCGGAAAATCTTT	0.358													A	111898484	A	A	111898484	3	1	125	1	0	0	0	0	1	0	0	0	14710	1116	39	2	748	2	SLC9A10	3	111898484	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	51576	111898484	86123946	18	8603											
PIK3CA	5290	broad.mit.edu	37	chr3	178916876	178916876	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attttttgatgaaacaagacGactttgtgaccttcggcttt	8	7	0	4	rs121913287		TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:178916876G>A	uc003fjk.2	+	2	420	c.263G>A	c.(262-264)CGA>CAA	p.R88Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	88	PI3K-ABD.		R -> Q (in cancer; may disrupt the interaction between the PI3K-ABD domain and the N-terminal lobe of PI3K/PI4K kinase domain possibly affecting the conformation of the kinase domain).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R88Q(26)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAACAAGACGACTTTGTGAC	0.363	R88Q(SKUT1_SOFT_TISSUE)|R88Q(JHUEM1_ENDOMETRIUM)|R88Q(SNGM_ENDOMETRIUM)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178916876	A	A	178916876	3	1	125	1	0	0	0	0	1	0	0	0	11913	1058	37	2	265	2	PIK3CA	3	178916876	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	67018392	178916876	19105554	19	8604											
PIK3CA	5290	broad.mit.edu	37	chr3	178916936	178916936	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aattgaaccagtaggcaaccGtgaagaaaagatcctcaatc	8	9	1	4			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:178916936G>A	uc003fjk.2	+	2	480	c.323G>A	c.(322-324)CGT>CAT	p.R108H		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	108	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R108H(5)|p.G106_R108del(2)|p.R108P(1)|p.R108del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GTAGGCAACCGTGAAGAAAAG	0.338		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178916936	A	A	178916936	3	1	125	1	0	0	0	0	1	0	0	0	11913	1145	40	1	325	1	PIK3CA	3	178916936	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	60	178916936	19105494	20	8605											
MUC4	4585	broad.mit.edu	37	chr3	195484190	195484190	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acttgggtgtccacagcaacGtcccattctctgccccgggg	11	15	1	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr3:195484190G>A	uc011bto.1	-	19	15072	c.14612C>T	c.(14611-14613)ACG>ATG	p.T4871M	MUC4_uc003fuz.2_Missense_Mutation_p.T597M|MUC4_uc003fva.2_Missense_Mutation_p.T479M|MUC4_uc003fvb.2_Missense_Mutation_p.T515M|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Missense_Mutation_p.T515M|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Missense_Mutation_p.T479M|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Missense_Mutation_p.T563M|MUC4_uc011bti.1_Missense_Mutation_p.T563M|MUC4_uc011btj.1_Missense_Mutation_p.T740M|MUC4_uc011btk.1_Missense_Mutation_p.T479M|MUC4_uc011btl.1_Missense_Mutation_p.T508M|MUC4_uc011btm.1_Missense_Mutation_p.T688M|MUC4_uc011btn.1_Missense_Mutation_p.T479M|MUC4_uc003fvo.2_Missense_Mutation_p.T763M|MUC4_uc003fvp.2_Missense_Mutation_p.T712M	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1756					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CCACAGCAACGTCCCATTCTC	0.572													A	195484190	A	A	195484190	3	1	125	1	0	0	0	0	1	0	0	0	9978	1145	40	1	1274	1	MUC4	3	195484190	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	16567254	195484190	2538240	21	8606											
MFSD7	84179	broad.mit.edu	37	chr4	680077	680077	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcccggcaaagttcagccaCgcacccaggatggtctgcga	11	15	2	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr4:680077C>T	uc003gay.2	-	3	366	c.309G>A	c.(307-309)GCG>GCA	p.A103A	MFSD7_uc003gaw.2_5'Flank|MFSD7_uc003gax.2_Silent_p.A103A|MFSD7_uc003gaz.2_Intron|MFSD7_uc003gba.2_Intron|MFSD7_uc003gbb.1_Silent_p.A39A	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	103	Helical; (Potential).				transmembrane transport	integral to membrane					0						AGTTCAGCCACGCACCCAGGA	0.652													T	680077	T	T	680077	2	4	125	1	0	0	0	0	0	0	0	1	9537	523	19	1		1	MFSD7	4	680077	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08		680077	190474199	22	8607											
KDR	3791	broad.mit.edu	37	chr4	55961059	55961059	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgatgctgtccaagcgccGtttcagatccacagggattg	13	10	1	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr4:55961059G>A	uc003has.2	-	21	3183	c.2881C>T	c.(2881-2883)CGG>TGG	p.R961W	KDR_uc003hat.1_Missense_Mutation_p.R961W	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	961	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TCCAAGCGCCGTTTCAGATCC	0.488			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			A	55961059	A	A	55961059	3	1	125	1	0	0	0	0	1	0	0	0	8139	1144	40	1	1229	1	KDR	4	55961059	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	55280982	55961059	135193217	23	8608											
FBN2	2201	broad.mit.edu	37	chr5	127623046	127623046	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggcatagccaatcgggcaCgtgcattcataggacccaaa	11	11	1	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr5:127623046C>T	uc003kuu.2	-	54	7273	c.6834G>A	c.(6832-6834)ACG>ACA	p.T2278T		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2278	EGF-like 38; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CAATCGGGCACGTGCATTCAT	0.483													T	127623046	T	T	127623046	2	4	125	1	0	0	0	0	0	0	0	1	5703	523	19	1		1	FBN2	5	127623046	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08		127623046	53292214	24	8609											
WNT8A	7478	broad.mit.edu	37	chr5	137426568	137426568	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acacatccaggtgggagcgaCgtagctgtgggcgcctgtgc	16	11	0	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr5:137426568C>T	uc003lcd.1	+	6	867	c.862C>T	c.(862-864)CGT>TGT	p.R288C	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Missense_Mutation_p.R306C|WNT8A_uc011cyk.1_Missense_Mutation_p.R306C	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	288					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GTGGGAGCGACGTAGCTGTGG	0.542													T	137426568	T	T	137426568	3	4	125	1	0	0	0	0	1	0	0	0	17393	536	19	1	884	1	WNT8A	5	137426568	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	9803522	137426568	43488692	25	8610											
DND1	373863	broad.mit.edu	37	chr5	140052370	140052370	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgctgaaggtcatcatcagGcggaactcgtagaggcggcc	14	12	3	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr5:140052370G>A	uc003lgt.2	-	3	308	c.264C>T	c.(262-264)CGC>CGT	p.R88R		NM_194249	NP_919225	Q8IYX4	DND1_HUMAN	dead end homolog 1	88	RRM 1.				multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCATCATCAGGCGGAACTCGT	0.667													A	140052370	A	A	140052370	2	1	125	1	0	0	0	0	0	0	0	1	4666	1190	42	3		3	DND1	5	140052370	Silent	SNP	G	TCGA-12-5301-01A-01D-1486-08	2625802	140052370	40862890	26	8611											
GABRB2	2561	broad.mit.edu	37	chr5	160721276	160721276	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttccagagcatttcggccaaAactatgcctgggcaacccag	9	13	0	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr5:160721276A>G	uc003lys.1	-	11	1569	c.1351T>C	c.(1351-1353)TTT>CTT	p.F451L	GABRB2_uc011deh.1_Missense_Mutation_p.F252L|GABRB2_uc003lyr.1_Missense_Mutation_p.F413L|GABRB2_uc003lyt.1_Missense_Mutation_p.F413L|GABRB2_uc010jiu.1_Missense_Mutation_p.F350L	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	451	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTTCGGCCAAAACTATGCCTG	0.527													G	160721276	G	G	160721276	3	3	125	1	0	0	0	0	1	0	0	0	6167	14	1	4	191	4	GABRB2	5	160721276	Missense_Mutation	SNP	A	TCGA-12-5301-01A-01D-1486-08	20668906	160721276	20193984	27	8612											
NOP16	51491	broad.mit.edu	37	chr5	175811029	175811030	+	Frame_Shift_Ins	INS	-	C	C													ggttctggcttttccgtgaaINScccccagatgaatataaatt							TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr5:175811029_175811030insC	uc003mee.2	-	5	651_652	c.651_652insG	c.(649-654)GGGTTCfs	p.G217fs	NOP16_uc003med.2_Frame_Shift_Ins_p.G216fs			Q9Y3C1	NOP16_HUMAN	SubName: Full=NOP16 protein; SubName: Full=Putative uncharacterized protein HSPC111;	Error:Variant_position_missing_in_Q9Y3C1_after_alignment						nucleolus				ovary(1)|central_nervous_system(1)	2						TTTTCCGTGAACCCCCAGATGA	0.436													C	175811030	C	C	175811029	7	5	125	1	0	1	1	0	0	0	0	0	10537	58	2	0		0	NOP16	5	175811029	Frame_Shift_Ins	INS	-	TCGA-12-5301-01A-01D-1486-08	15089753	175811029	5104231	28	8613											
ZNF451	26036	broad.mit.edu	37	chr6	57013164	57013164	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagtttatgttcggcaAcagcacagaatttaaccgac	9	10	0	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr6:57013164A>G	uc003pdm.1	+	10	2505	c.2281A>G	c.(2281-2283)ACA>GCA	p.T761A	ZNF451_uc003pdl.2_Missense_Mutation_p.T761A|ZNF451_uc003pdn.1_Missense_Mutation_p.T761A|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.T761A	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	761	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ATGTTCGGCAACAGCACAGAA	0.408													G	57013164	G	G	57013164	3	3	125	1	0	0	0	0	1	0	0	0	17919	43	2	4	2319	4	ZNF451	6	57013164	Missense_Mutation	SNP	A	TCGA-12-5301-01A-01D-1486-08		57013164	114101903	29	8614											
C6orf221	154288	broad.mit.edu	37	chr6	74073368	74073368	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgggaggccgggacgcagCgttcggtggaggtccgggag	21	10	0	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr6:74073368C>T	uc003pgt.3	+	3	492	c.439C>T	c.(439-441)CGT>TGT	p.R147C		NM_001017361	NP_001017361	Q587J8	ECAT1_HUMAN	hypothetical protein LOC154288	147										skin(2)	2						CGGGACGCAGCGTTCGGTGGA	0.667													T	74073368	T	T	74073368	3	4	125	1	0	0	0	0	1	0	0	0	2355	768	27	1	449	1	C6orf221	6	74073368	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	17060204	74073368	97041699	30	8615											
HEY2	23493	broad.mit.edu	37	chr6	126080280	126080280	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taggctactttgacgcacacGctcttgccatggacttcatg	9	12	2	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr6:126080280G>A	uc003qad.2	+	5	537	c.346G>A	c.(346-348)GCT>ACT	p.A116T	HEY2_uc011ebr.1_Missense_Mutation_p.A70T	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	116	Transcriptional repression and interaction with NCOR1 and SIN3A (By similarity).				negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		TGACGCACACGCTCTTGCCAT	0.522													A	126080280	A	A	126080280	3	1	125	1	0	0	0	0	1	0	0	0	7079	1087	38	1	364	1	HEY2	6	126080280	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	52006912	126080280	45034787	31	8616											
CALCR	799	broad.mit.edu	37	chr7	93072970	93072970	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctcagtaaacacagccaCgacaatgagtgtatgaagat	8	9	1	3			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr7:93072970C>T	uc003umv.1	-	10	1111	c.850G>A	c.(850-852)GTG>ATG	p.V284M	CALCR_uc011kia.1_Missense_Mutation_p.V64M|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.V250M|CALCR_uc003umw.2_Missense_Mutation_p.V250M	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	266	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	AACACAGCCACGACAATGAGT	0.448													T	93072970	T	T	93072970	3	4	125	1	0	0	0	0	1	0	0	0	2579	536	19	1	700	1	CALCR	7	93072970	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08		93072970	66065693	32	8617											
JHDM1D	80853	broad.mit.edu	37	chr7	139833358	139833358	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttgggaagactcgagagcGtaattccttaatgaaagttc	10	8	0	3			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr7:139833358G>A	uc003vvm.2	-	3	383	c.379C>T	c.(379-381)CGC>TGC	p.R127C		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	127					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					ACTCGAGAGCGTAATTCCTTA	0.378													A	139833358	A	A	139833358	3	1	125	1	0	0	0	0	1	0	0	0	7948	1145	40	1	2518	1	JHDM1D	7	139833358	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	46760388	139833358	19305305	33	8618											
EPHB6	2051	broad.mit.edu	37	chr7	142568575	142568575	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcctgccctgggcatcacccTggctggccaccagaagaagc	12	16	1	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr7:142568575T>A	uc011kst.1	+	20	3771	c.2984T>A	c.(2983-2985)CTG>CAG	p.L995Q	EPHB6_uc011ksu.1_Missense_Mutation_p.L995Q|EPHB6_uc003wbs.2_Missense_Mutation_p.L703Q|EPHB6_uc003wbt.2_Missense_Mutation_p.L469Q|EPHB6_uc003wbu.2_Missense_Mutation_p.L703Q|EPHB6_uc003wbv.2_Missense_Mutation_p.L379Q	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	995	SAM.|Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GGCATCACCCTGGCTGGCCAC	0.617													A	142568575	A	A	142568575	3	1	125	1	0	0	0	0	1	0	0	0	5178	1580	55	5	3046	5	EPHB6	7	142568575	Missense_Mutation	SNP	T	TCGA-12-5301-01A-01D-1486-08	2735217	142568575	16570088	34	8619											
KEL	3792	broad.mit.edu	37	chr7	142638355	142638355	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagttaccagagctggcagCggctggaggggttcaagaga	16	8	1	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr7:142638355C>T	uc003wcb.2	-	19	2393	c.2183G>A	c.(2182-2184)CGC>CAC	p.R728H		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	728	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GAGCTGGCAGCGGCTGGAGGG	0.567													T	142638355	T	T	142638355	3	4	125	1	0	0	0	0	1	0	0	0	8142	768	27	1	19	1	KEL	7	142638355	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	69780	142638355	16500308	35	8620											
XKR6	286046	broad.mit.edu	37	chr8	11058779	11058779	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctcgccgccgctgcccaCcgcctcgtccaggttgtgca	10	20	0	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr8:11058779C>T	uc003wtk.1	-	1	97	c.70G>A	c.(70-72)GTG>ATG	p.V24M		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	24	Gly-rich.					integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		CCGCTGCCCACCGCCTCGTCC	0.552													T	11058779	T	T	11058779	3	4	125	1	0	0	0	0	1	0	0	0	17432	507	18	3	1867	3	XKR6	8	11058779	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08		11058779	135305243	36	8621											
TMEM215	401498	broad.mit.edu	37	chr9	32784817	32784817	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgctcctacaagcagaaCagcccgtatgacagatactg	9	11	0	3			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr9:32784817C>T	uc003zri.3	+	2	1001	c.636C>T	c.(634-636)AAC>AAT	p.N212N		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	212						integral to membrane					0						ACAAGCAGAACAGCCCGTATG	0.493													T	32784817	T	T	32784817	2	4	125	1	0	0	0	0	0	0	0	1	16135	477	17	3		3	TMEM215	9	32784817	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08		32784817	108428614	37	8622											
CCIN	881	broad.mit.edu	37	chr9	36170861	36170861	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgacaccagcactggggaCgtggtccagtgtatcacctt	11	11	1	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr9:36170861C>T	uc003zzb.3	+	1	1473	c.1362C>T	c.(1360-1362)GAC>GAT	p.D454D		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	454	Kelch 4.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			GCACTGGGGACGTGGTCCAGT	0.557													T	36170861	T	T	36170861	2	4	125	1	0	0	0	0	0	0	0	1	2878	535	19	1		1	CCIN	9	36170861	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	3386044	36170861	105042570	38	8623											
FOXB2	442425	broad.mit.edu	37	chr9	79634932	79634932	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaccatactcacttgcacgCgggaagcaccaagagcgcgc	11	15	1	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr9:79634932C>T	uc004ako.1	+	1	362	c.362C>T	c.(361-363)GCG>GTG	p.A121V		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	121					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CACTTGCACGCGGGAAGCACC	0.507													T	79634932	T	T	79634932	3	4	125	1	0	0	0	0	1	0	0	0	5993	768	27	1	364	1	FOXB2	9	79634932	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	43464071	79634932	61578499	39	8624											
ZNF618	114991	broad.mit.edu	37	chr9	116731434	116731434	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccggaaggaaaagcactgCgagcaggtacactccctctc	11	13	1	0	rs143368881	by1000genomes	TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr9:116731434C>T	uc004bid.2	+	2	170	c.71C>T	c.(70-72)GCG>GTG	p.A24V	ZNF618_uc004bib.1_Missense_Mutation_p.A24V|ZNF618_uc004bic.2_Missense_Mutation_p.A24V|ZNF618_uc011lxi.1_Missense_Mutation_p.A24V|ZNF618_uc011lxj.1_Missense_Mutation_p.A24V	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAAGCACTGCGAGCAGGTAC	0.557													T	116731434	T	T	116731434	3	4	125	1	0	0	0	0	1	0	0	0	18039	768	27	1	77	1	ZNF618	9	116731434	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	37096502	116731434	24481997	40	8625											
DBH	1621	broad.mit.edu	37	chr9	136517375	136517375	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcctgccccaggagatccGcatgttgaagaaggtcgtgt	13	11	0	3			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr9:136517375G>A	uc004cel.2	+	8	1352	c.1343G>A	c.(1342-1344)CGC>CAC	p.R448H		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	448	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CAGGAGATCCGCATGTTGAAG	0.672													A	136517375	A	A	136517375	3	1	125	1	0	0	0	0	1	0	0	0	4250	1087	38	1	1373	1	DBH	9	136517375	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	19785941	136517375	4696056	41	8626											
SLC34A3	142680	broad.mit.edu	37	chr9	140127306	140127306	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggctggactggtcattggCgtgctggtcacagccctggt	16	10	2	0	rs142873841	byFrequency	TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr9:140127306C>T	uc004cmf.1	+	5	561	c.375C>T	c.(373-375)GGC>GGT	p.G125G	SLC34A3_uc004cmc.1_5'UTR|SLC34A3_uc004cmd.1_Silent_p.G125G|SLC34A3_uc011met.1_Silent_p.G125G	NM_080877	NP_543153	Q8N130	NPT2C_HUMAN	solute carrier family 34 (sodium phosphate),	125	Helical; Name=M2; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TGGTCATTGGCGTGCTGGTCA	0.617													T	140127306	T	T	140127306	2	4	125	1	0	0	0	0	0	0	0	1	14569	755	27	1		1	SLC34A3	9	140127306	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	3609931	140127306	1086125	42	8627											
C10orf47	254427	broad.mit.edu	37	chr10	11908649	11908649	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgctgtgcgatggaggagtGtgctgcctctgctccccgtc	15	12	1	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr10:11908649G>A	uc001ikx.2	+	3	412	c.258G>A	c.(256-258)GTG>GTA	p.V86V	uc001iky.1_Intron	NM_153256	NP_694988	Q86WR7	CJ047_HUMAN	hypothetical protein LOC254427	86										central_nervous_system(1)	1						ATGGAGGAGTGTGCTGCCTCT	0.577													A	11908649	A	A	11908649	2	1	125	1	0	0	0	0	0	0	0	1	1605	1364	48	3		3	C10orf47	10	11908649	Silent	SNP	G	TCGA-12-5301-01A-01D-1486-08		11908649	123626098	43	8628											
PPYR1	5540	broad.mit.edu	37	chr10	47086808	47086808	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acacctctcacctcctggccTtgctgctcccaaaatctcca	4	19	2	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr10:47086808T>A	uc001jee.2	+	3	444	c.25T>A	c.(25-27)TTG>ATG	p.L9M	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Missense_Mutation_p.L9M	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	9	Extracellular (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						CCTCCTGGCCTTGCTGCTCCC	0.493													A	47086808	A	A	47086808	3	1	125	1	0	0	0	0	1	0	0	0	12416	1606	56	5	27	5	PPYR1	10	47086808	Missense_Mutation	SNP	T	TCGA-12-5301-01A-01D-1486-08	35178159	47086808	88447939	44	8629											
PPYR1	5540	broad.mit.edu	37	chr10	47087737	47087737	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggcctccacctgcgtcaaCccattcatctatggctttct	6	15	4	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr10:47087737C>T	uc001jee.2	+	3	1373	c.954C>T	c.(952-954)AAC>AAT	p.N318N	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.N318N	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	318	Helical; Name=7; (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						CCTGCGTCAACCCATTCATCT	0.572													T	47087737	T	T	47087737	2	4	125	1	0	0	0	0	0	0	0	1	12416	506	18	3		3	PPYR1	10	47087737	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	929	47087737	88447010	45	8630											
KIAA0913	23053	broad.mit.edu	37	chr10	75553915	75553915	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtgccctcaggtgaagctggCataccaggagtctgaggtgg	16	9	2	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr10:75553915C>G	uc009xrl.2	+	13	2668	c.2636C>G	c.(2635-2637)GCA>GGA	p.A879G	KIAA0913_uc001jve.2_Missense_Mutation_p.A879G|KIAA0913_uc001jvf.2_Missense_Mutation_p.A879G|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.A302G|KIAA0913_uc010qkr.1_Missense_Mutation_p.A302G|KIAA0913_uc001jvj.2_Missense_Mutation_p.A302G	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	879							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GTGAAGCTGGCATACCAGGAG	0.552													G	75553915	G	G	75553915	3	3	125	1	0	0	0	0	1	0	0	0	8200	710	25	5	2686	5	KIAA0913	10	75553915	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	28466178	75553915	59980832	46	8631											
EBF3	253738	broad.mit.edu	37	chr10	131755521	131755521	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaataaagaagtcatccttaCctgtcaatgattacagggtc	7	8	2	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr10:131755521C>G	uc001lki.1	-	6	613	c.554_splice	c.e6+1	p.R185_splice		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GTCATCCTTACCTGTCAATGA	0.423													G	131755521	G	G	131755521	5	3	125	1	0	0	0	0	0	0	1	0	4882	521	18	5	1144	5	EBF3	10	131755521	Splice_Site	SNP	C	TCGA-12-5301-01A-01D-1486-08	56201606	131755521	3779226	47	8632											
ZNF215	7762	broad.mit.edu	37	chr11	6977376	6977376	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgtgggaaagccttctgcCgaagttcatcccttattcga	9	10	2	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr11:6977376C>T	uc001mey.2	+	7	1756	c.1168C>T	c.(1168-1170)CGA>TGA	p.R390*	ZNF215_uc010raw.1_3'UTR|ZNF215_uc010rax.1_Nonsense_Mutation_p.R152*|ZNF215_uc001mez.1_Intron	NM_013250	NP_037382	Q9UL58	ZN215_HUMAN	zinc finger protein 215	390	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		AGCCTTCTGCCGAAGTTCATC	0.393													T	6977376	T	T	6977376	4	4	125	1	0	0	0	0	0	1	0	0	17768	644	23	2	1186	2	ZNF215	11	6977376	Nonsense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08		6977376	128029140	48	8633											
OR5P2	120065	broad.mit.edu	37	chr11	7818191	7818191	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgactgttgcaaagaaagccGctgaaccaagctggatggca	12	10	0	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr11:7818191G>A	uc001mfp.1	-	1	299	c.299C>T	c.(298-300)GCG>GTG	p.A100V		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	100	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAAGAAAGCCGCTGAACCAAG	0.483													A	7818191	A	A	7818191	3	1	125	1	0	0	0	0	1	0	0	0	11178	1087	38	1	673	1	OR5P2	11	7818191	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	840815	7818191	127188325	49	8634											
OR5I1	10798	broad.mit.edu	37	chr11	55703444	55703444	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatgacaagacaatcaaccGcatacagatgcccctagaca	7	12	1	4			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr11:55703444G>A	uc010ris.1	-	1	433	c.433C>T	c.(433-435)CGG>TGG	p.R145W		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACAATCAACCGCATACAGATG	0.428													A	55703444	A	A	55703444	3	1	125	1	0	0	0	0	1	0	0	0	11164	1086	38	1	514	1	OR5I1	11	55703444	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	47885253	55703444	79303072	50	8635											
FGD4	121512	broad.mit.edu	37	chr12	32763711	32763711	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttctttttttcccatttagaAtcacttgaaattatatctac	2	8	3	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr12:32763711A>G	uc001rkz.2	+	9	1611	c.1134A>G	c.(1132-1134)AAA>AAG	p.K378K	FGD4_uc001rlc.2_Silent_p.K463K|FGD4_uc001rky.2_Silent_p.K130K|FGD4_uc001rla.2_Silent_p.K34K|FGD4_uc010ske.1_Silent_p.K490K|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	378	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					CCCATTTAGAATCACTTGAAA	0.343													G	32763711	G	G	32763711	2	3	125	1	0	0	0	0	0	0	0	1	5835	115	4	4		4	FGD4	12	32763711	Silent	SNP	A	TCGA-12-5301-01A-01D-1486-08		32763711	101088184	51	8636											
KRT75	9119	broad.mit.edu	37	chr12	52818468	52818468	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagtagccgctgcccccacCgaggcccaggtttccacctc	11	18	0	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr12:52818468C>T	uc001saj.2	-	9	1511	c.1489G>A	c.(1489-1491)GGT>AGT	p.G497S		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	497	Tail.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		CTGCCCCCACCGAGGCCCAGG	0.622													T	52818468	T	T	52818468	3	4	125	1	0	0	0	0	1	0	0	0	8488	652	23	2	170	2	KRT75	12	52818468	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	20054757	52818468	81033427	52	8637											
KRT6B	3854	broad.mit.edu	37	chr12	52841572	52841572	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agttacccacctgcactcctCgccctccagcagcttgcggt	8	18	0	0	rs60627726		TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr12:52841572C>T	uc001sak.2	-	7	1462	c.1414G>A	c.(1414-1416)GAG>AAG	p.E472K		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	472	Rod.|Coil 2.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		CTGCACTCCTCGCCCTCCAGC	0.597													T	52841572	T	T	52841572	3	4	125	1	0	0	0	0	1	0	0	0	8481	893	31	2	292	2	KRT6B	12	52841572	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	23104	52841572	81010323	53	8638											
ANO4	121601	broad.mit.edu	37	chr12	101295584	101295584	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atggaggcaagctcttctggAatcactaatggaaaaaccaa	9	8	3	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr12:101295584A>G	uc010svm.1	+	2	593	c.21A>G	c.(19-21)GGA>GGG	p.G7G	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Silent_p.G7G|ANO4_uc001thx.2_Silent_p.G7G	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	7	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GCTCTTCTGGAATCACTAATG	0.522										HNSCC(74;0.22)			G	101295584	G	G	101295584	2	3	125	1	0	0	0	0	0	0	0	1	699	233	9	4		4	ANO4	12	101295584	Silent	SNP	A	TCGA-12-5301-01A-01D-1486-08	48454012	101295584	32556311	54	8639											
ACACB	32	broad.mit.edu	37	chr12	109629703	109629703	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgcggggccttgaacgtgGccgatgcgatgttcagaacg	15	9	1	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr12:109629703G>A	uc001tob.2	+	15	2466	c.2347G>A	c.(2347-2349)GCC>ACC	p.A783T	ACACB_uc001toc.2_Missense_Mutation_p.A783T	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	783					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CTTGAACGTGGCCGATGCGAT	0.532													A	109629703	A	A	109629703	3	1	125	1	0	0	0	0	1	0	0	0	107	1203	42	3	2401	3	ACACB	12	109629703	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	8334119	109629703	24222192	55	8640											
VPS33A	65082	broad.mit.edu	37	chr12	122734578	122734578	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tctctcttcatcctgatcatCatattggccacttgctggaa	6	12	5	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr12:122734578C>G	uc001ucd.2	-	6	728	c.615G>C	c.(613-615)ATG>ATC	p.M205I	VPS33A_uc001ucc.2_RNA	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	205					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		TCCTGATCATCATATTGGCCA	0.383													G	122734578	G	G	122734578	3	3	125	1	0	0	0	0	1	0	0	0	17198	826	29	5	1207	5	VPS33A	12	122734578	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	13104875	122734578	11117317	56	8641											
PARP4	143	broad.mit.edu	37	chr13	25052379	25052379	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgagcaggagtctggtgccaTctgtctctcccgggtgtgag	15	10	3	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr13:25052379T>C	uc001upl.2	-	13	1590	c.1484A>G	c.(1483-1485)GAT>GGT	p.D495G	PARP4_uc010tdc.1_Missense_Mutation_p.D495G	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	495	PARP catalytic.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TCTGGTGCCATCTGTCTCTCC	0.438													C	25052379	C	C	25052379	3	2	125	1	0	0	0	0	1	0	0	0	11463	1435	50	4	3778	4	PARP4	13	25052379	Missense_Mutation	SNP	T	TCGA-12-5301-01A-01D-1486-08		25052379	90117499	57	8642											
NBEA	26960	broad.mit.edu	37	chr13	36124652	36124652	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggacttcacggaaaatggatGttcagcgagatacgagctgt	13	7	2	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr13:36124652G>A	uc001uvb.2	+	42	6830	c.6624G>A	c.(6622-6624)ATG>ATA	p.M2208I	NBEA_uc010abi.2_Missense_Mutation_p.M864I|NBEA_uc010tee.1_Missense_Mutation_p.M1I|NBEA_uc010tef.1_Missense_Mutation_p.M1I|NBEA_uc010teg.1_Missense_Mutation_p.M1I	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2208						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GAAAATGGATGTTCAGCGAGA	0.363													A	36124652	A	A	36124652	3	1	125	1	0	0	0	0	1	0	0	0	10187	1377	48	3	6790	3	NBEA	13	36124652	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	11072273	36124652	79045226	58	8643											
SLITRK1	114798	broad.mit.edu	37	chr13	84455093	84455093	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttcagcctgttaccccggaGgtcgaggtgggtgatgggca	16	9	1	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr13:84455093G>C	uc001vlk.2	-	1	1436	c.550C>G	c.(550-552)CTC>GTC	p.L184V		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	184	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTACCCCGGAGGTCGAGGTGG	0.532													C	84455093	C	C	84455093	3	2	125	1	0	0	0	0	1	0	0	0	14742	1000	35	5	1544	5	SLITRK1	13	84455093	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	48330441	84455093	30714785	59	8644											
NALCN	259232	broad.mit.edu	37	chr13	101707744	101707744	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaccgcaggaagccgcgtcaGtcatggggttcattttgcac	12	11	3	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr13:101707744G>A	uc001vox.1	-	44	5309	c.5120C>T	c.(5119-5121)ACT>ATT	p.T1707I		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1707	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGCCGCGTCAGTCATGGGGTT	0.507													A	101707744	A	A	101707744	3	1	125	1	0	0	0	0	1	0	0	0	10148	1029	36	3	100	3	NALCN	13	101707744	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	17252651	101707744	13462134	60	8645											
OR4M1	441670	broad.mit.edu	37	chr14	20248846	20248846	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagtgatggcctatgaccGctatgctgctatctgccgac	10	13	1	2	rs143164519	byFrequency	TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr14:20248846G>A	uc010tku.1	+	1	365	c.365G>A	c.(364-366)CGC>CAC	p.R122H		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCCTATGACCGCTATGCTGCT	0.502													A	20248846	A	A	20248846	3	1	125	1	0	0	0	0	1	0	0	0	11075	1087	38	1	367	1	OR4M1	14	20248846	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08		20248846	87100694	61	8646											
SUPT16H	11198	broad.mit.edu	37	chr14	21826560	21826560	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaatttttaaaggctgttttCagtttgtgcctcatttctcg	7	7	3	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr14:21826560C>T	uc001wao.2	-	20	2667	c.2328G>A	c.(2326-2328)CTG>CTA	p.L776L	SUPT16H_uc001wan.2_5'UTR	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	776					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		AGGCTGTTTTCAGTTTGTGCC	0.378													T	21826560	T	T	21826560	2	4	125	1	0	0	0	0	0	0	0	1	15393	813	29	3		3	SUPT16H	14	21826560	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	1577714	21826560	85522980	62	8647											
CTSG	1511	broad.mit.edu	37	chr14	25044566	25044566	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggactctggatctgaagataCgccatgtaggggcgggagtg	17	7	2	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr14:25044566C>T	uc001wpq.2	-	2	145	c.108G>A	c.(106-108)GCG>GCA	p.A36A		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	36	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		TCTGAAGATACGCCATGTAGG	0.572													T	25044566	T	T	25044566	2	4	125	1	0	0	0	0	0	0	0	1	4035	523	19	1		1	CTSG	14	25044566	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	3218006	25044566	82304974	63	8648											
ANPEP	290	broad.mit.edu	37	chr15	90348339	90348339	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttggatgcctgcttctccacGtagtcgaactcactgacaat	8	12	2	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr15:90348339G>C	uc002bop.3	-	4	1159	c.867C>G	c.(865-867)TAC>TAG	p.Y289*		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	289	Extracellular.|Interaction with HCoV-229E.|Metalloprotease.			DYVEKQAS->QSVEETAQ: No change in receptor activity and HCoV-229E infection.|DYVEKQAS->QSVNETAQ: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity.|DYVEKQAS->QSVNEQAQ: No change in receptor activity and HCoV-229E infection.	angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GCTTCTCCACGTAGTCGAACT	0.567													C	90348339	C	C	90348339	4	2	125	1	0	0	0	0	0	1	0	0	710	1140	40	5	2108	5	ANPEP	15	90348339	Nonsense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08		90348339	12183053	64	8649											
TPSD1	23430	broad.mit.edu	37	chr16	1306608	1306608	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggtgagcctgagagtccgCggcccatactggatgcactt	13	12	0	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr16:1306608C>T	uc002clb.1	+	2	183	c.174C>T	c.(172-174)CGC>CGT	p.R58R	TPSD1_uc010brm.1_5'UTR	NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	58	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				TGAGAGTCCGCGGCCCATACT	0.697													T	1306608	T	T	1306608	2	4	125	1	0	0	0	0	0	0	0	1	16422	755	27	1		1	TPSD1	16	1306608	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08		1306608	89048145	65	8650											
RBBP6	5930	broad.mit.edu	37	chr16	24552109	24552109	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcaccaatgcgcagacgaaAgaaggtaagggccgcttggt	13	9	1	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr16:24552109A>G	uc002dmh.2	+	1	1202	c.162A>G	c.(160-162)AAA>AAG	p.K54K	RBBP6_uc010vcb.1_Intron|RBBP6_uc002dmg.2_Silent_p.K54K|RBBP6_uc002dmi.2_Silent_p.K54K|RBBP6_uc010bxr.2_Silent_p.K54K	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	54	DWNN.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		CGCAGACGAAAGAAGGTAAGG	0.517													G	24552109	G	G	24552109	2	3	125	1	0	0	0	0	0	0	0	1	13103	69	3	4		4	RBBP6	16	24552109	Silent	SNP	A	TCGA-12-5301-01A-01D-1486-08	23245501	24552109	65802644	66	8651											
OR1A1	8383	broad.mit.edu	37	chr17	3119210	3119210	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcttttgggggatgcctaaCgcagatgtatttcatgatag	11	7	2	2	rs144175148	byFrequency	TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr17:3119210C>T	uc010vrc.1	+	1	296	c.296C>T	c.(295-297)ACG>ATG	p.T99M		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGATGCCTAACGCAGATGTAT	0.488													T	3119210	T	T	3119210	3	4	125	1	0	0	0	0	1	0	0	0	10949	536	19	1	298	1	OR1A1	17	3119210	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08		3119210	78076000	67	8652											
DNAH2	146754	broad.mit.edu	37	chr17	7679385	7679385	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccatgagggtgaccctgcGggaccttctccggaactgcc	13	14	1	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr17:7679385G>A	uc002giu.1	+	30	4879	c.4865G>A	c.(4864-4866)CGG>CAG	p.R1622Q		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1622	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GTGACCCTGCGGGACCTTCTC	0.627													A	7679385	A	A	7679385	3	1	125	1	0	0	0	0	1	0	0	0	4602	1116	39	2	4983	2	DNAH2	17	7679385	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	4560175	7679385	73515825	68	8653											
MYO15A	51168	broad.mit.edu	37	chr17	18047889	18047889	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgagcaccatgcagaagccGtgagcatcttcaagctggta	11	12	2	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr17:18047889G>A	uc010vxh.1	+	28	6594	c.6256G>A	c.(6256-6258)GTG>ATG	p.V2086M		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2086	Tail.|MyTH4 1.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGCAGAAGCCGTGAGCATCTT	0.607													A	18047889	A	A	18047889	3	1	125	1	0	0	0	0	1	0	0	0	10063	1145	40	1	6362	1	MYO15A	17	18047889	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	10368504	18047889	63147321	69	8654											
GPR179	440435	broad.mit.edu	37	chr17	36484987	36484987	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagactcagcatttcctgccCcatcacgttatcatccagct	5	16	3	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr17:36484987C>T	uc002hpz.2	-	11	4486	c.4465G>A	c.(4465-4467)GGG>AGG	p.G1489R		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1489	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				ATTTCCTGCCCCATCACGTTA	0.512													T	36484987	T	T	36484987	3	4	125	1	0	0	0	0	1	0	0	0	6674	623	22	3	2642	3	GPR179	17	36484987	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08	18437098	36484987	44710223	70	8655											
PGAP3	93210	broad.mit.edu	37	chr17	37844120	37844120	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagattggctggcgggagcGgaagtgattcagagcgcccc	17	9	1	3			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr17:37844120G>A	uc002hsj.2	-	1	191	c.148C>T	c.(148-150)CGC>TGC	p.R50C	ERBB2_uc002hsm.2_5'Flank|ERBB2_uc010cwa.2_5'Flank|PGAP3_uc010wej.1_Missense_Mutation_p.R50C|PGAP3_uc002hsk.2_Missense_Mutation_p.R50C|PGAP3_uc010cvz.2_Missense_Mutation_p.R50C|ERBB2_uc002hsl.2_5'Flank	NM_033419	NP_219487	Q96FM1	PGAP3_HUMAN	per1-like domain containing 1 precursor	50	Lumenal (Potential).				GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			upper_aerodigestive_tract(1)	1						TGGCGGGAGCGGAAGTGATTC	0.657													A	37844120	A	A	37844120	3	1	125	1	0	0	0	0	1	0	0	0	11779	1116	39	2	846	2	PGAP3	17	37844120	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	1359133	37844120	43351090	71	8656											
CLTC	1213	broad.mit.edu	37	chr17	57746279	57746279	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagcaactgctacgatcctgAgcgagtcaagaattttctta	8	9	2	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr17:57746279A>G	uc002ixq.1	+	14	2713	c.2270A>G	c.(2269-2271)GAG>GGG	p.E757G	CLTC_uc002ixp.2_Missense_Mutation_p.E757G|CLTC_uc002ixr.1_Missense_Mutation_p.E761G	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	757	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TACGATCCTGAGCGAGTCAAG	0.398			T	ALK|TFE3	ALCL|renal 								G	57746279	G	G	57746279	3	3	125	1	0	0	0	0	1	0	0	0	3566	304	11	4	2324	4	CLTC	17	57746279	Missense_Mutation	SNP	A	TCGA-12-5301-01A-01D-1486-08	19902159	57746279	23448931	72	8657											
GAA	2548	broad.mit.edu	37	chr17	78082609	78082609	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gagctgcaccagggcggccgGcgctacatgatgatcgtggt	16	11	0	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr17:78082609G>T	uc002jxo.2	+	9	1490	c.1308G>T	c.(1306-1308)CGG>CGT	p.R436R	GAA_uc002jxp.2_Silent_p.R436R|GAA_uc002jxq.2_Silent_p.R436R	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	436					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	AGGGCGGCCGGCGCTACATGA	0.642													T	78082609	T	T	78082609	2	4	125	1	0	0	0	0	0	0	0	1	6147	1190	42	5		5	GAA	17	78082609	Silent	SNP	G	TCGA-12-5301-01A-01D-1486-08	20336330	78082609	3112601	73	8658											
CEP76	79959	broad.mit.edu	37	chr18	12699056	12699056	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acatggaacaggtttagaacGaaaacgttggtttcgataat	10	5	0	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr18:12699056G>A	uc002kri.2	-	4	598	c.442C>T	c.(442-444)CGT>TGT	p.R148C	PSMG2_uc002krg.2_Intron|CEP76_uc002krh.3_5'UTR|CEP76_uc010wzz.1_Intron|CEP76_uc010xaa.1_5'UTR|CEP76_uc010xab.1_3'UTR	NM_024899	NP_079175	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	148					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding				0						GGTTTAGAACGAAAACGTTGG	0.373													A	12699056	A	A	12699056	3	1	125	1	0	0	0	0	1	0	0	0	3261	1058	37	2	1573	2	CEP76	18	12699056	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08		12699056	65378192	74	8659											
MC5R	4161	broad.mit.edu	37	chr18	13826367	13826367	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttcgctatgctgttcctcctGgtgtctctgtacatacacat	7	12	1	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr18:13826367G>T	uc010xaf.1	+	1	603	c.603G>T	c.(601-603)CTG>CTT	p.L201L		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	201	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TGTTCCTCCTGGTGTCTCTGT	0.587													T	13826367	T	T	13826367	2	4	125	1	0	0	0	0	0	0	0	1	9367	1335	47	5		5	MC5R	18	13826367	Silent	SNP	G	TCGA-12-5301-01A-01D-1486-08	1127311	13826367	64250881	75	8660											
POTEC	388468	broad.mit.edu	37	chr18	14542740	14542740	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgtccagatcttctcgacGgacgtggtacctcggctcca	10	14	2	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr18:14542740G>A	uc010dln.2	-	1	860	c.406C>T	c.(406-408)CGT>TGT	p.R136C	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	136										skin(3)	3						TCTTCTCGACGGACGTGGTAC	0.602													A	14542740	A	A	14542740	3	1	125	1	0	0	0	0	1	0	0	0	12262	1116	39	2	1266	2	POTEC	18	14542740	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	716373	14542740	63534508	76	8661											
ATP8B1	5205	broad.mit.edu	37	chr18	55328473	55328473	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atggctttcttgtacctcttCaccaggtccaccaccatggc	7	15	3	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr18:55328473C>T	uc002lgw.2	-	21	2640	c.2640G>A	c.(2638-2640)GTG>GTA	p.V880V	uc002lgu.1_Intron|uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	880	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				TGTACCTCTTCACCAGGTCCA	0.582									Byler_disease				T	55328473	T	T	55328473	2	4	125	1	0	0	0	0	0	0	0	1	1194	813	29	3		3	ATP8B1	18	55328473	Silent	SNP	C	TCGA-12-5301-01A-01D-1486-08	40785733	55328473	22748775	77	8662											
TNFSF9	8744	broad.mit.edu	37	chr19	6535064	6535064	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagccggactcccttcacCgaggtcggaataacgtccag	10	16	1	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr19:6535064C>T	uc002mfh.2	+	3	790	c.752C>T	c.(751-753)CCG>CTG	p.P251L		NM_003811	NP_003802	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily,	251	Extracellular (Potential).				apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						CTCCCTTCACCGAGGTCGGAA	0.637													T	6535064	T	T	6535064	3	4	125	1	0	0	0	0	1	0	0	0	16309	652	23	2	762	2	TNFSF9	19	6535064	Missense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08		6535064	52593919	78	8663											
MUC16	94025	broad.mit.edu	37	chr19	9068085	9068085	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taagggtaccctgtgatgtcGccctatgaggacctgtttgg	13	9	0	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr19:9068085G>A	uc002mkp.2	-	3	19565	c.19361C>T	c.(19360-19362)GCG>GTG	p.A6454V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6456	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGATGTCGCCCTATGAGG	0.498													A	9068085	A	A	9068085	3	1	125	1	0	0	0	0	1	0	0	0	9973	1087	38	1	24490	1	MUC16	19	9068085	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	2533021	9068085	50060898	79	8664											
RFX1	5989	broad.mit.edu	37	chr19	14104590	14104591	+	Frame_Shift_Ins	INS	-	G	G													gctggggctgggcttgtggcINSggggcctgtggcggctggga							TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr19:14104590_14104591insG	uc002mxv.2	-	2	337_338	c.65_66insC	c.(64-66)CCGfs	p.P22fs	RFX1_uc010dzi.2_Frame_Shift_Ins_p.P22fs	NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	22					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			gggcttgtggcggggcctgtgg	0.149													G	14104591	G	G	14104590	7	5	125	1	0	1	1	0	0	0	0	0	13262	755	27	0	2953	0	RFX1	19	14104590	Frame_Shift_Ins	INS	-	TCGA-12-5301-01A-01D-1486-08	5036505	14104590	45024393	80	8665											
SLC25A42	284439	broad.mit.edu	37	chr19	19217127	19217127	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccggcgcactggctggaacgAcagccgcttcactgacctac	11	16	1	1	rs145774094	by1000genomes	TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr19:19217127A>C	uc002nlf.1	+	6	581	c.430A>C	c.(430-432)ACA>CCA	p.T144P	SLC25A42_uc010xqn.1_Missense_Mutation_p.T196P	NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	144	Helical; Name=3; (Potential).|Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			GGCTGGAACGACAGCCGCTTC	0.642													C	19217127	C	C	19217127	3	2	125	1	0	0	0	0	1	0	0	0	14507	275	10	5	448	5	SLC25A42	19	19217127	Missense_Mutation	SNP	A	TCGA-12-5301-01A-01D-1486-08	5112537	19217127	39911856	81	8666											
MLL4	9757	broad.mit.edu	37	chr19	36219962	36219962	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcactctgcctcaaatacggGgatgcagactccaaggtgag	12	11	2	2			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr19:36219962G>A	uc010eei.2	+	22	4764	c.4764G>A	c.(4762-4764)GGG>GGA	p.G1588G		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1588					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCAAATACGGGGATGCAGACT	0.607													A	36219962	A	A	36219962	2	1	125	1	0	0	0	0	0	0	0	1	9623	1219	43	3		3	MLL4	19	36219962	Silent	SNP	G	TCGA-12-5301-01A-01D-1486-08	17002835	36219962	22909021	82	8667											
NLRP12	91662	broad.mit.edu	37	chr19	54314124	54314124	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaagatgaggtcttgcatGctgcattccgtggcactctg	12	10	2	3			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr19:54314124G>A	uc002qch.3	-	3	1009	c.789C>T	c.(787-789)AGC>AGT	p.S263S	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.S263S|NLRP12_uc002qcj.3_Silent_p.S263S|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.S263S	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	263	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GGTCTTGCATGCTGCATTCCG	0.567													A	54314124	A	A	54314124	2	1	125	1	0	0	0	0	0	0	0	1	10474	1310	46	3		3	NLRP12	19	54314124	Silent	SNP	G	TCGA-12-5301-01A-01D-1486-08	18094162	54314124	4814859	83	8668											
JPH2	57158	broad.mit.edu	37	chr20	42788558	42788558	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcttccactcgcccatgtagGtctcggtggtggtggcgtcg	14	12	2	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr20:42788558G>C	uc002xli.1	-	2	1742	c.869C>G	c.(868-870)ACC>AGC	p.T290S		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	290	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GCCCATGTAGGTCTCGGTGGT	0.701													C	42788558	C	C	42788558	3	2	125	1	0	0	0	0	1	0	0	0	7961	1261	44	5	1237	5	JPH2	20	42788558	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08		42788558	20236962	84	8669											
CDH22	64405	broad.mit.edu	37	chr20	44828064	44828064	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgtggcgcccagctcacccGcctccatggccagcactgtg	12	18	1	0			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr20:44828064G>A	uc002xrm.2	-	7	1822	c.1421C>T	c.(1420-1422)GCG>GTG	p.A474V	CDH22_uc010ghk.1_Missense_Mutation_p.A474V	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	474	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				CAGCTCACCCGCCTCCATGGC	0.667													A	44828064	A	A	44828064	3	1	125	1	0	0	0	0	1	0	0	0	3107	1087	38	1	1085	1	CDH22	20	44828064	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	2039506	44828064	18197456	85	8670											
USP16	10600	broad.mit.edu	37	chr21	30409731	30409731	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attctccttgccaaataaccGtgaaaggactcagtaatttg	7	9	2	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr21:30409731G>A	uc002ymy.2	+	6	785	c.583G>A	c.(583-585)GTG>ATG	p.V195M	USP16_uc002ymx.2_Missense_Mutation_p.V194M|USP16_uc002ymw.2_Missense_Mutation_p.V195M|USP16_uc011acm.1_Missense_Mutation_p.V180M|USP16_uc011acn.1_Intron|USP16_uc011aco.1_5'Flank	NM_006447	NP_006438	Q9Y5T5	UBP16_HUMAN	ubiquitin specific protease 16 isoform a	195					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4						CCAAATAACCGTGAAAGGACT	0.348													A	30409731	A	A	30409731	3	1	125	1	0	0	0	0	1	0	0	0	17044	1145	40	1	601	1	USP16	21	30409731	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08		30409731	17720164	86	8671											
FBLN1	2192	broad.mit.edu	37	chr22	45944523	45944524	+	Frame_Shift_Ins	INS	-	CCAC	CCAC													tgcgccctgcccaccgggggINSccacatctgctcctaccgct							TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr22:45944523_45944524insCCAC	uc003bgj.1	+	13	1619_1620	c.1472_1473insCCAC	c.(1471-1473)GGCfs	p.G491fs	FBLN1_uc003bgg.1_Frame_Shift_Ins_p.G491fs|FBLN1_uc003bgh.2_Frame_Shift_Ins_p.G491fs|FBLN1_uc010gzz.2_Frame_Shift_Ins_p.G529fs|FBLN1_uc003bgi.1_Frame_Shift_Ins_p.G491fs	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	491	EGF-like 8; calcium-binding.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCCACCGGGGGCCACATCTGCT	0.644													CCAC	45944524	CCAC	CCAC	45944523	7	5	125	1	0	1	1	0	0	0	0	0	5698	1203	42	0	1522	0	FBLN1	22	45944523	Frame_Shift_Ins	INS	-	TCGA-12-5301-01A-01D-1486-08		45944523	5360043	87	8672											
TUBGCP6	85378	broad.mit.edu	37	chr22	50657589	50657589	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcatagtgcgcctccaggtGcagctccacgaagaagtagt	11	12	1	1			TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chr22:50657589G>A	uc003bkb.1	-	20	5046	c.4534C>T	c.(4534-4536)CAC>TAC	p.H1512Y	TUBGCP6_uc003bka.1_Missense_Mutation_p.H599Y|TUBGCP6_uc010har.1_Missense_Mutation_p.H1504Y|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1512					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCCTCCAGGTGCAGCTCCACG	0.642													A	50657589	A	A	50657589	3	1	125	1	0	0	0	0	1	0	0	0	16767	1319	46	3	949	3	TUBGCP6	22	50657589	Missense_Mutation	SNP	G	TCGA-12-5301-01A-01D-1486-08	4713066	50657589	646977	88	8673											
F9	2158	broad.mit.edu	37	chrX	138643736	138643736	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agcaaaagcgaaatgtgattCgaattattcctcaccacaac	6	10	1	1	rs137852250		TCGA-12-5301-01A-01D-1486-08	TCGA-12-5301-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	891fc6bc-d0a7-4064-842c-43d500b4ef5d	0961643d-a43d-493f-a3aa-d3dfdef330ed	g.chrX:138643736C>T	uc004fas.1	+	8	921	c.892C>T	c.(892-894)CGA>TGA	p.R298*	F9_uc004fat.1_Nonsense_Mutation_p.R260*	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	298	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	AAATGTGATTCGAATTATTCC	0.353													T	138643736	T	T	138643736	4	4	125	1	0	0	0	0	0	1	0	0	5351	876	31	2	922	2	F9	23	138643736	Nonsense_Mutation	SNP	C	TCGA-12-5301-01A-01D-1486-08		138643736	16626824	89	8674											
CYP4A11	1579	broad.mit.edu	37	chr1	47402416	47402416	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaggctggggtcagcatccGtcgatgctggaaccatgtct	14	10	2	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr1:47402416G>A	uc001cqp.3	-	4	481	c.430C>T	c.(430-432)CGG>TGG	p.R144W	CYP4A11_uc001cqq.2_Missense_Mutation_p.R144W|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	144					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GTCAGCATCCGTCGATGCTGG	0.443													A	47402416	A	A	47402416	3	1	126	1	0	0	0	0	1	0	0	0	4183	1144	40	1	1165	1	CYP4A11	1	47402416	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08		47402416	201848205	1	8675											
DOCK7	85440	broad.mit.edu	37	chr1	63001286	63001286	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	atcttttggtcttgtacattCgtagaaaatccagaactctg	7	8	3	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr1:63001286C>A	uc001daq.2	-	29	3523	c.3489G>T	c.(3487-3489)ACG>ACT	p.T1163T	DOCK7_uc001dan.2_Silent_p.T1024T|DOCK7_uc001dao.2_Silent_p.T1024T|DOCK7_uc001dap.2_Silent_p.T1132T|DOCK7_uc001dam.2_Silent_p.T343T|DOCK7_uc010oov.1_5'UTR	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1163					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CTTGTACATTCGTAGAAAATC	0.398													A	63001286	A	A	63001286	2	1	126	1	0	0	0	0	0	0	0	1	4692	871	31	5		5	DOCK7	1	63001286	Silent	SNP	C	TCGA-14-0740-01B-01D-1845-08	15598870	63001286	186249335	2	8676											
VTCN1	79679	broad.mit.edu	37	chr1	117699373	117699373	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catttcatcctgctccgacaGctcatctttgccttctttga	5	14	4	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr1:117699373G>A	uc001ehb.2	-	3	340	c.268C>T	c.(268-270)CTG>TTG	p.L90L	VTCN1_uc001ehc.2_5'UTR|VTCN1_uc009whf.1_Intron	NM_024626	NP_078902	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation	90	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane					0	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		TGCTCCGACAGCTCATCTTTG	0.458													A	117699373	A	A	117699373	2	1	126	1	0	0	0	0	0	0	0	1	17231	962	34	3		3	VTCN1	1	117699373	Silent	SNP	G	TCGA-14-0740-01B-01D-1845-08	54698087	117699373	131551248	3	8677											
TXNIP	10628	broad.mit.edu	37	chr1	145440100	145440100	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcattcctgatgggcgggtGtctgtctctgctcgaattga	12	9	3	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr1:145440100G>A	uc001enn.3	+	4	875	c.534G>A	c.(532-534)GTG>GTA	p.V178V	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Silent_p.V123V	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	178					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATGGGCGGGTGTCTGTCTCTG	0.433													A	145440100	A	A	145440100	2	1	126	1	0	0	0	0	0	0	0	1	16800	1364	48	3		3	TXNIP	1	145440100	Silent	SNP	G	TCGA-14-0740-01B-01D-1845-08	27740727	145440100	103810521	4	8678											
NR1I3	9970	broad.mit.edu	37	chr1	161203002	161203002	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatggtgcccatgtggcggGtgtgggcccccaggagtgtc	17	11	0	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr1:161203002G>A	uc001fzx.2	-	4	568	c.365C>T	c.(364-366)ACC>ATC	p.T122I	TOMM40L_uc009wuf.1_Intron|NR1I3_uc001fzf.2_Missense_Mutation_p.T122I|NR1I3_uc001fzg.2_Missense_Mutation_p.T93I|NR1I3_uc001fzh.2_Missense_Mutation_p.T93I|NR1I3_uc001fzi.2_Missense_Mutation_p.T93I|NR1I3_uc001fzj.2_Missense_Mutation_p.T93I|NR1I3_uc001fzk.2_Missense_Mutation_p.T93I|NR1I3_uc001fzl.2_Missense_Mutation_p.T93I|NR1I3_uc001fzm.2_Missense_Mutation_p.T47I|NR1I3_uc001fzn.2_Intron|NR1I3_uc009wug.2_Intron|NR1I3_uc001fzp.2_Missense_Mutation_p.T122I|NR1I3_uc001fzo.2_Intron|NR1I3_uc001fzq.2_Intron|NR1I3_uc001fzr.2_Intron|NR1I3_uc001fzs.2_Intron|NR1I3_uc001fzt.2_Intron|NR1I3_uc001fzu.2_Intron|NR1I3_uc001fzv.2_Intron|NR1I3_uc001fzw.2_Missense_Mutation_p.T122I|NR1I3_uc001fzy.2_Missense_Mutation_p.T122I|NR1I3_uc001fzz.2_Missense_Mutation_p.T122I|NR1I3_uc001gaa.2_Missense_Mutation_p.T122I|NR1I3_uc001gab.2_Missense_Mutation_p.T122I|NR1I3_uc001gac.2_Missense_Mutation_p.T93I|NR1I3_uc010pkm.1_Missense_Mutation_p.T93I|NR1I3_uc010pkn.1_Missense_Mutation_p.T122I	NM_001077480	NP_001070948	Q14994	NR1I3_HUMAN	constitutive androstane receptor isoform 2	122					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(1)|skin(1)	2	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CATGTGGCGGGTGTGGGCCCC	0.557													A	161203002	A	A	161203002	3	1	126	1	0	0	0	0	1	0	0	0	10621	1261	44	3	827	3	NR1I3	1	161203002	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08	15762902	161203002	88047619	5	8679											
SLC30A3	7781	broad.mit.edu	37	chr2	27481038	27481038	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggggccttacctgaacggtGccagccaaaggtcatggtgc	14	11	1	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr2:27481038G>A	uc002rjk.2	-	3	601	c.415C>T	c.(415-417)CAC>TAC	p.H139Y	SLC30A3_uc002rjj.2_5'UTR|SLC30A3_uc010ylh.1_Missense_Mutation_p.H134Y	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	139	Cytoplasmic (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTGAACGGTGCCAGCCAAAG	0.637													A	27481038	A	A	27481038	3	1	126	1	0	0	0	0	1	0	0	0	14556	1319	46	3	775	3	SLC30A3	2	27481038	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08		27481038	215718335	6	8680											
IL1A	3552	broad.mit.edu	37	chr2	113537182	113537182	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aattcgtatttgatgatcctCataaagttgtatttcacatt	5	6	2	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr2:113537182C>T	uc002tig.2	-	5	1341	c.381G>A	c.(379-381)ATG>ATA	p.M127I		NM_000575	NP_000566	P01583	IL1A_HUMAN	interleukin 1, alpha proprotein	127					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			lung(1)	1						TGATGATCCTCATAAAGTTGT	0.393													T	113537182	T	T	113537182	3	4	126	1	0	0	0	0	1	0	0	0	7650	826	29	3	446	3	IL1A	2	113537182	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	86056144	113537182	129662191	7	8681											
ARMC9	80210	broad.mit.edu	37	chr2	232127073	232127073	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agaccgttctgcaagcctacAtcagcaatgacctcttggac	8	13	3	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr2:232127073A>T	uc002vrq.3	+	12	1193	c.1081A>T	c.(1081-1083)ATC>TTC	p.I361F	ARMC9_uc002vrp.3_Missense_Mutation_p.I361F|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	361							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		GCAAGCCTACATCAGCAATGA	0.498													T	232127073	T	T	232127073	3	4	126	1	0	0	0	0	1	0	0	0	958	217	8	5	1123	5	ARMC9	2	232127073	Missense_Mutation	SNP	A	TCGA-14-0740-01B-01D-1845-08	118589891	232127073	11072300	8	8682											
RAD54L2	23132	broad.mit.edu	37	chr3	51690165	51690165	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgtgcaggagtccttgtgCagaaggtggtcaccacgaca	14	10	1	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr3:51690165C>T	uc011bdt.1	+	19	3330	c.3205C>T	c.(3205-3207)CAG>TAG	p.Q1069*	RAD54L2_uc003dbh.2_Nonsense_Mutation_p.Q658*|RAD54L2_uc011bdu.1_Nonsense_Mutation_p.Q763*|RAD54L2_uc003dbj.2_Nonsense_Mutation_p.Q395*	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	1069						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		AGTCCTTGTGCAGAAGGTGGT	0.458													T	51690165	T	T	51690165	4	4	126	1	0	0	0	0	0	1	0	0	12994	711	25	3	3275	3	RAD54L2	3	51690165	Nonsense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08		51690165	146332265	9	8683											
DPPA2	151871	broad.mit.edu	37	chr3	109028077	109028077	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgcaaagtgtcccgacacacCttattaatgggaggcaaaat	9	10	0	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr3:109028077C>G	uc003dxo.2	-	4	529	c.282G>C	c.(280-282)AAG>AAC	p.K94N		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	94	SAP.					nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						CCCGACACACCTTATTAATGG	0.443													G	109028077	G	G	109028077	3	3	126	1	0	0	0	0	1	0	0	0	4734	680	24	5	634	5	DPPA2	3	109028077	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	57337912	109028077	88994353	10	8684											
PDGFRA	5156	broad.mit.edu	37	chr4	55133558	55133558	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cggtgaaagacagtggagatTacgaatgtgctgcccgccag	14	9	0	3			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr4:55133558T>C	uc003han.3	+	6	1193	c.862T>C	c.(862-864)TAC>CAC	p.Y288H	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.Y182H|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	288	Ig-like C2-type 3.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CAGTGGAGATTACGAATGTGC	0.473			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			C	55133558	C	C	55133558	3	2	126	1	0	0	0	0	1	0	0	0	11661	1754	61	4	880	4	PDGFRA	4	55133558	Missense_Mutation	SNP	T	TCGA-14-0740-01B-01D-1845-08		55133558	136020718	11	8685											
RBM46	166863	broad.mit.edu	37	chr4	155720138	155720138	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaacttagagattatgcttTtgttcactttttcaaccgag	7	7	2	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr4:155720138T>C	uc003ioo.2	+	4	997	c.824T>C	c.(823-825)TTT>TCT	p.F275S	RBM46_uc011cim.1_Missense_Mutation_p.F275S|RBM46_uc003iop.1_Missense_Mutation_p.F275S	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	275	RRM 3.						nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)				GATTATGCTTTTGTTCACTTT	0.363													C	155720138	C	C	155720138	3	2	126	1	0	0	0	0	1	0	0	0	13140	1841	64	4	834	4	RBM46	4	155720138	Missense_Mutation	SNP	T	TCGA-14-0740-01B-01D-1845-08	100586580	155720138	35434138	12	8686											
LPCAT1	79888	broad.mit.edu	37	chr5	1494825	1494825	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tctcactcacttccccagatCgggatgtctctgctctctgc	7	16	4	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr5:1494825C>A	uc003jcm.2	-	3	600	c.483G>T	c.(481-483)CCG>CCT	p.P161P		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	161	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TTCCCCAGATCGGGATGTCTC	0.597													A	1494825	A	A	1494825	2	1	126	1	0	0	0	0	0	0	0	1	8910	871	31	5		5	LPCAT1	5	1494825	Silent	SNP	C	TCGA-14-0740-01B-01D-1845-08		1494825	179420435	13	8687											
HSPB3	8988	broad.mit.edu	37	chr5	53751847	53751847	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactttcagatcctgctggaCgtggtccagttcctccctga	9	14	1	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr5:53751847C>T	uc003jph.1	+	1	403	c.228C>T	c.(226-228)GAC>GAT	p.D76D		NM_006308	NP_006299	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3	76					cell death|response to heat|response to unfolded protein	cytoplasm|nucleus					0		Lung NSC(810;0.00104)				TCCTGCTGGACGTGGTCCAGT	0.547													T	53751847	T	T	53751847	2	4	126	1	0	0	0	0	0	0	0	1	7421	535	19	1		1	HSPB3	5	53751847	Silent	SNP	C	TCGA-14-0740-01B-01D-1845-08	52257022	53751847	127163413	14	8688											
CTNNA1	1495	broad.mit.edu	37	chr5	138221907	138221907	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccttttatccaggctggaCgtaaagaaagaagtgatgca	10	7	0	3			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr5:138221907C>T	uc003ldh.2	+	8	1164	c.1069C>T	c.(1069-1071)CGT>TGT	p.R357C	CTNNA1_uc011cyx.1_Missense_Mutation_p.R254C|CTNNA1_uc011cyy.1_Missense_Mutation_p.R234C|CTNNA1_uc003ldi.2_Missense_Mutation_p.R55C|CTNNA1_uc003ldj.2_Missense_Mutation_p.R357C|CTNNA1_uc003ldl.2_Translation_Start_Site	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	357	Interaction with alpha-actinin.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCAGGCTGGACGTAAAGAAAG	0.378													T	138221907	T	T	138221907	3	4	126	1	0	0	0	0	1	0	0	0	4012	536	19	1	1095	1	CTNNA1	5	138221907	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	84470060	138221907	42693353	15	8689											
PCDHGA9	56107	broad.mit.edu	37	chr5	140782734	140782734	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcgtctctagaggtaggaCgcagcttttctctctgaacc	9	12	3	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr5:140782734C>T	uc003lkh.1	+	1	215	c.215C>T	c.(214-216)ACG>ATG	p.T72M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.T72M	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	72	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGTAGGACGCAGCTTTTC	0.622													T	140782734	T	T	140782734	3	4	126	1	0	0	0	0	1	0	0	0	11561	536	19	1	217	1	PCDHGA9	5	140782734	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	2560827	140782734	40132526	16	8690											
BTNL8	79908	broad.mit.edu	37	chr5	180377067	180377067	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccaagcagggaaacattaCtgggaggtggacggaggaca	15	7	0	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr5:180377067C>T	uc003mmp.2	+	8	1260	c.1026C>T	c.(1024-1026)TAC>TAT	p.Y342Y	BTNL8_uc003mmq.2_3'UTR|BTNL8_uc011dhg.1_Silent_p.Y217Y|BTNL8_uc010jll.2_3'UTR|BTNL8_uc010jlm.2_Silent_p.Y226Y|BTNL8_uc011dhh.1_Silent_p.Y158Y	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	342	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAAACATTACTGGGAGGTGG	0.522													T	180377067	T	T	180377067	2	4	126	1	0	0	0	0	0	0	0	1	1567	576	20	3		3	BTNL8	5	180377067	Silent	SNP	C	TCGA-14-0740-01B-01D-1845-08	39594333	180377067	538193	17	8691											
KIF13A	63971	broad.mit.edu	37	chr6	17772259	17772259	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgctttaaaagggctgacGgttaaggcatgaggagtctc	13	6	1	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr6:17772259G>A	uc003ncg.3	-	37	4461	c.4356C>T	c.(4354-4356)ACC>ACT	p.T1452T	KIF13A_uc003ncf.2_Silent_p.T1439T|KIF13A_uc003nch.3_Silent_p.T1452T|KIF13A_uc003nci.3_Silent_p.T1439T|KIF13A_uc003nce.1_Silent_p.T38T	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1452					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			AAGGGCTGACGGTTAAGGCAT	0.433													A	17772259	A	A	17772259	2	1	126	1	0	0	0	0	0	0	0	1	8274	1103	39	2		2	KIF13A	6	17772259	Silent	SNP	G	TCGA-14-0740-01B-01D-1845-08		17772259	153342808	18	8692											
DAXX	1616	broad.mit.edu	37	chr6	33289539	33289539	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcttgtagcatttcttgCcgcccgaactactgcttcct	7	15	1	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr6:33289539C>T	uc003oec.2	-	2	368	c.164G>A	c.(163-165)GGC>GAC	p.G55D	DAXX_uc011drd.1_Intron|DAXX_uc011dre.1_Missense_Mutation_p.G67D|DAXX_uc003oed.2_Missense_Mutation_p.G55D|DAXX_uc010juw.2_5'UTR	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	55	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						GCATTTCTTGCCGCCCGAACT	0.597			Mis|F|N		Pancreatic neuroendocrine tumors								T	33289539	T	T	33289539	3	4	126	1	0	0	0	0	1	0	0	0	4243	739	26	3	2086	3	DAXX	6	33289539	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	15517280	33289539	137825528	19	8693											
KPNA5	3841	broad.mit.edu	37	chr6	117023258	117023258	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggtagtgattgaaactggggCtgttccgatttttatcaaac	11	6	1	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr6:117023258C>G	uc003pxh.2	+	6	643	c.512C>G	c.(511-513)GCT>GGT	p.A171G		NM_002269	NP_002260	O15131	IMA5_HUMAN	karyopherin alpha 5	168	ARM 3.|NLS binding site (major) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		GAAACTGGGGCTGTTCCGATT	0.318													G	117023258	G	G	117023258	3	3	126	1	0	0	0	0	1	0	0	0	8433	797	28	5	534	5	KPNA5	6	117023258	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	83733719	117023258	54091809	20	8694											
UTRN	7402	broad.mit.edu	37	chr6	144757266	144757266	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagtcaaagaccagtttgcaAcccatgaagtaaatatctgt	7	8	2	2	rs150684617		TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr6:144757266A>T	uc003qkt.2	+	9	1143	c.1051A>T	c.(1051-1053)ACC>TCC	p.T351S	UTRN_uc010khq.1_Missense_Mutation_p.T351S	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	351	Interaction with SYNM.|Spectrin 2.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CCAGTTTGCAACCCATGAAGT	0.453													T	144757266	T	T	144757266	3	4	126	1	0	0	0	0	1	0	0	0	17100	43	2	5	1085	5	UTRN	6	144757266	Missense_Mutation	SNP	A	TCGA-14-0740-01B-01D-1845-08	27734008	144757266	26357801	21	8695											
DMTF1	9988	broad.mit.edu	37	chr7	86811558	86811558	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttaggctccggataaagcAtggcaatgactgggcaacaa	11	8	0	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr7:86811558A>G	uc003uih.2	+	10	1051	c.725A>G	c.(724-726)CAT>CGT	p.H242R	DMTF1_uc003uii.2_5'UTR|DMTF1_uc003uij.2_5'UTR|DMTF1_uc011khb.1_Missense_Mutation_p.H154R|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.H242R|DMTF1_uc003uin.2_5'UTR	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	242	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Myb-like 1.|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					CGGATAAAGCATGGCAATGAC	0.433													G	86811558	G	G	86811558	3	3	126	1	0	0	0	0	1	0	0	0	4592	217	8	4	755	4	DMTF1	7	86811558	Missense_Mutation	SNP	A	TCGA-14-0740-01B-01D-1845-08		86811558	72327105	22	8696											
TRPV5	56302	broad.mit.edu	37	chr7	142605705	142605705	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatggtagacctcctctccaTccccctcactaaggttcagt	6	15	3	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr7:142605705T>C	uc003wby.1	-	15	2429	c.2165A>G	c.(2164-2166)GAT>GGT	p.D722G		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	722	Cytoplasmic (Potential).|Involved in Ca(2+)-dependent inactivation (By similarity).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CTCCTCTCCATCCCCCTCACT	0.567													C	142605705	C	C	142605705	3	2	126	1	0	0	0	0	1	0	0	0	16596	1435	50	4	28	4	TRPV5	7	142605705	Missense_Mutation	SNP	T	TCGA-14-0740-01B-01D-1845-08	55794147	142605705	16532958	23	8697											
PTK2B	2185	broad.mit.edu	37	chr8	27296903	27296903	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttcacgacagccagtgacGtctggatgttcggtgagtgc	14	10	2	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr8:27296903G>A	uc003xfn.1	+	25	2630	c.1822G>A	c.(1822-1824)GTC>ATC	p.V608I	PTK2B_uc003xfo.1_Missense_Mutation_p.V608I|PTK2B_uc003xfp.1_Missense_Mutation_p.V608I|PTK2B_uc003xfq.1_Missense_Mutation_p.V608I|PTK2B_uc003xfr.1_Missense_Mutation_p.V354I	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	608	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		AGCCAGTGACGTCTGGATGTT	0.547													A	27296903	A	A	27296903	3	1	126	1	0	0	0	0	1	0	0	0	12763	1145	40	1	1896	1	PTK2B	8	27296903	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08		27296903	119067119	24	8698											
GEM	2669	broad.mit.edu	37	chr8	95264452	95264452	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggagccattcattttccccCtaatgaaacaataagatctt	5	10	2	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr8:95264452C>T	uc003ygj.2	-	4	658	c.409_splice	c.e4-1	p.G137_splice	GEM_uc003ygi.2_Splice_Site_p.G137_splice	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein						cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			CATTTTCCCCCTAATGAAACA	0.453													T	95264452	T	T	95264452	5	4	126	1	0	0	0	0	0	0	1	0	6329	695	24	3	490	3	GEM	8	95264452	Splice_Site	SNP	C	TCGA-14-0740-01B-01D-1845-08	67967549	95264452	51099570	25	8699											
ZFAT	57623	broad.mit.edu	37	chr8	135613849	135613849	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctgaccggtgctcaggggCagctttgcaagagtcaggct	15	11	2	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr8:135613849C>T	uc003yup.2	-	6	2288	c.2113G>A	c.(2113-2115)GCC>ACC	p.A705T	ZFAT_uc003yun.2_Missense_Mutation_p.A693T|ZFAT_uc003yuo.2_Missense_Mutation_p.A693T|ZFAT_uc010meh.2_Missense_Mutation_p.A693T|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.A693T|ZFAT_uc010mej.2_Missense_Mutation_p.A643T|ZFAT_uc003yur.2_Missense_Mutation_p.A693T	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGCTCAGGGGCAGCTTTGCAA	0.557													T	135613849	T	T	135613849	3	4	126	1	0	0	0	0	1	0	0	0	17629	710	25	3	1662	3	ZFAT	8	135613849	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	40349397	135613849	10750173	26	8700											
DOCK8	81704	broad.mit.edu	37	chr9	439344	439344	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagtacttcaccgagagtGgcctggtaggcctcctggag	14	12	1	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr9:439344G>A	uc003zgf.2	+	40	5291	c.5179G>A	c.(5179-5181)GGC>AGC	p.G1727S	DOCK8_uc010mgu.2_Missense_Mutation_p.G1029S|DOCK8_uc010mgv.2_Missense_Mutation_p.G1627S|DOCK8_uc003zgk.2_Missense_Mutation_p.G1185S	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1727	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CACCGAGAGTGGCCTGGTAGG	0.622													A	439344	A	A	439344	3	1	126	1	0	0	0	0	1	0	0	0	4693	1348	47	3	5337	3	DOCK8	9	439344	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08		439344	140774087	27	8701											
COL15A1	1306	broad.mit.edu	37	chr9	101788194	101788194	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgttccccagggccctgaGggacagcctggagttgatgg	16	10	0	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr9:101788194G>A	uc004azb.1	+	16	2195	c.1989G>A	c.(1987-1989)GAG>GAA	p.E663E		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	663	Triple-helical region 2 (COL2).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				AGGGCCCTGAGGGACAGCCTG	0.582													A	101788194	A	A	101788194	2	1	126	1	0	0	0	0	0	0	0	1	3672	991	35	3		3	COL15A1	9	101788194	Silent	SNP	G	TCGA-14-0740-01B-01D-1845-08	101348850	101788194	39425237	28	8702											
ABCA1	19	broad.mit.edu	37	chr9	107555100	107555100	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttgatttctaagatgtcattCtggcctccaccatcaagaat	6	10	4	3			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr9:107555100C>G	uc004bcl.2	-	42	6037	c.5724G>C	c.(5722-5724)CAG>CAC	p.Q1908H		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1908					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGATGTCATTCTGGCCTCCAC	0.423													G	107555100	G	G	107555100	3	3	126	1	0	0	0	0	1	0	0	0	28	912	32	5	1097	5	ABCA1	9	107555100	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	5766906	107555100	33658331	29	8703											
GBGT1	26301	broad.mit.edu	37	chr9	136031442	136031442	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttctccctcttgtagtgcaGcttcatgttgctggtggcag	11	11	3	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr9:136031442G>T	uc004ccw.2	-	4	429	c.148C>A	c.(148-150)CTG>ATG	p.L50M	RALGDS_uc011mcw.1_Missense_Mutation_p.A62D|GBGT1_uc004ccx.2_Missense_Mutation_p.L3M|GBGT1_uc010nab.2_Missense_Mutation_p.L50M|GBGT1_uc011mcx.1_Intron|GBGT1_uc010nac.1_Translation_Start_Site|GBGT1_uc004ccy.1_Missense_Mutation_p.L50M	NM_021996	NP_068836	Q8N5D6	GBGT1_HUMAN	globoside	50	Lumenal (Potential).				carbohydrate metabolic process|glycolipid biosynthetic process	Golgi membrane|integral to membrane	metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		TTGTAGTGCAGCTTCATGTTG	0.567													T	136031442	T	T	136031442	3	4	126	1	0	0	0	0	1	0	0	0	6272	962	34	5	911	5	GBGT1	9	136031442	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08	28476342	136031442	5181989	30	8704											
MYST4	23522	broad.mit.edu	37	chr10	76735758	76735758	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcatatctataccactcagGgacagtctcgcaaaaaggga	8	11	4	0	rs146395020	byFrequency	TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr10:76735758G>A	uc001jwn.1	+	8	2156	c.1663G>A	c.(1663-1665)GGA>AGA	p.G555R	MYST4_uc001jwm.1_Intron|MYST4_uc001jwo.1_Intron|MYST4_uc001jwp.1_Intron	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	555	Negatively regulates HAT activity.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					TACCACTCAGGGACAGTCTCG	0.493			T	CREBBP	AML								A	76735758	A	A	76735758	3	1	126	1	0	0	0	0	1	0	0	0	10105	1233	43	3	1685	3	MYST4	10	76735758	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08		76735758	58798989	31	8705											
CYP2C18	1562	broad.mit.edu	37	chr10	96443660	96443660	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagctctggaagagggagGctcccgtctggccccactcc	13	15	2	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr10:96443660G>A	uc001kjv.3	+	1	410	c.84G>A	c.(82-84)AGG>AGA	p.R28R	CYP2C18_uc001kjw.3_Silent_p.R28R	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	28					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GAAGAGGGAGGCTCCCGTCTG	0.483													A	96443660	A	A	96443660	2	1	126	1	0	0	0	0	0	0	0	1	4165	1194	42	3		3	CYP2C18	10	96443660	Silent	SNP	G	TCGA-14-0740-01B-01D-1845-08	19707902	96443660	39091087	32	8706											
CYP2C19	1557	broad.mit.edu	37	chr10	96612523	96612523	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgggagagggcctggcccGcatggagctgtttttattcc	15	9	0	1	rs138112316		TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr10:96612523G>A	uc010qnz.1	+	9	1325	c.1325G>A	c.(1324-1326)CGC>CAC	p.R442H	CYP2C19_uc010qny.1_Missense_Mutation_p.R420H	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	442			R -> C (in allele CYP2C19*16; lowered catalytic activity).		exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GGCCTGGCCCGCATGGAGCTG	0.433													A	96612523	A	A	96612523	3	1	126	1	0	0	0	0	1	0	0	0	4166	1087	38	1	1359	1	CYP2C19	10	96612523	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08	168863	96612523	38922224	33	8707											
BTBD16	118663	broad.mit.edu	37	chr10	124066797	124066797	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	attcaggcaattccgacttaTgaaaccgtgatgacattttt	7	8	1	3			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr10:124066797T>A	uc001lgc.1	+	10	1136	c.885T>A	c.(883-885)TAT>TAA	p.Y295*	BTBD16_uc001lgd.1_Nonsense_Mutation_p.Y294*	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	295										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TTCCGACTTATGAAACCGTGA	0.353													A	124066797	A	A	124066797	4	1	126	1	0	0	0	0	0	1	0	0	1541	1471	51	5	919	5	BTBD16	10	124066797	Nonsense_Mutation	SNP	T	TCGA-14-0740-01B-01D-1845-08	27454274	124066797	11467950	34	8708											
OR4C46	119749	broad.mit.edu	37	chr11	51515606	51515606	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aacatttcttcggaggtgcaGagggcatcctacttactgtg	11	9	1	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr11:51515606G>A	uc010ric.1	+	1	325	c.325G>A	c.(325-327)GAG>AAG	p.E109K		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CGGAGGTGCAGAGGGCATCCT	0.473													A	51515606	A	A	51515606	3	1	126	1	0	0	0	0	1	0	0	0	11051	943	33	3	327	3	OR4C46	11	51515606	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08		51515606	83490910	35	8709											
CPSF6	11052	broad.mit.edu	37	chr12	69652697	69652697	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttacactagctcctcctcCgcatcttcctggaccacctc	4	20	1	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr12:69652697C>T	uc001sut.3	+	6	1132	c.1022C>T	c.(1021-1023)CCG>CTG	p.P341L	CPSF6_uc001suu.3_Missense_Mutation_p.P378L|CPSF6_uc010stk.1_5'UTR	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	341	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			GCTCCTCCTCCGCATCTTCCT	0.617													T	69652697	T	T	69652697	3	4	126	1	0	0	0	0	1	0	0	0	3829	652	23	2	1044	2	CPSF6	12	69652697	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08		69652697	64199198	36	8710											
SLC6A15	55117	broad.mit.edu	37	chr12	85255645	85255645	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cctctcttataggtcacagaTgctaaattaccagaactatc	5	11	2	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr12:85255645T>A	uc001szv.2	-	12	2452	c.1959A>T	c.(1957-1959)GCA>GCT	p.A653A	SLC6A15_uc010sul.1_Silent_p.A546A|SLC6A15_uc001szw.1_Missense_Mutation_p.H315L	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	653	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						AGGTCACAGATGCTAAATTAC	0.438													A	85255645	A	A	85255645	2	1	126	1	0	0	0	0	0	0	0	1	14678	1451	51	5		5	SLC6A15	12	85255645	Silent	SNP	T	TCGA-14-0740-01B-01D-1845-08	15602948	85255645	48596250	37	8711											
ARL1	400	broad.mit.edu	37	chr12	101794864	101794864	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aacatggcaactaactctgaTttggaaatgccaattcggtc	8	9	1	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr12:101794864T>A	uc001tib.2	-	4	461	c.312A>T	c.(310-312)AAA>AAT	p.K104N	ARL1_uc010svn.1_Missense_Mutation_p.K58N|ARL1_uc010svo.1_RNA|ARL1_uc001tic.2_Missense_Mutation_p.K104N	NM_001177	NP_001168	P40616	ARL1_HUMAN	ADP-ribosylation factor-like 1	104					small GTPase mediated signal transduction	Golgi membrane	enzyme activator activity|GTP binding|GTPase activity|metal ion binding|protein binding			central_nervous_system(1)	1		Lung NSC(355;2.1e-05)|Breast(359;0.00015)|Myeloproliferative disorder(1001;0.163)		GBM - Glioblastoma multiforme(134;1.67e-09)|BRCA - Breast invasive adenocarcinoma(302;0.0125)		CTAACTCTGATTTGGAAATGC	0.348													A	101794864	A	A	101794864	3	1	126	1	0	0	0	0	1	0	0	0	925	1490	52	5	245	5	ARL1	12	101794864	Missense_Mutation	SNP	T	TCGA-14-0740-01B-01D-1845-08	16539219	101794864	32057031	38	8712											
CDX2	1045	broad.mit.edu	37	chr13	28537311	28537311	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccccagaaccccagggacagAgccaggcactgaggcttgca	12	15	0	3			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr13:28537311A>G	uc001urv.2	-	3	1057	c.883T>C	c.(883-885)TCT>CCT	p.S295P		NM_001265	NP_001256	Q99626	CDX2_HUMAN	caudal type homeobox 2	295					organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		CCAGGGACAGAGCCAGGCACT	0.657			T	ETV6	AML								G	28537311	G	G	28537311	3	3	126	1	0	0	0	0	1	0	0	0	3183	304	11	4	62	4	CDX2	13	28537311	Missense_Mutation	SNP	A	TCGA-14-0740-01B-01D-1845-08		28537311	86632567	39	8713											
TEP1	7011	broad.mit.edu	37	chr14	20841727	20841727	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cggttaccaccagaagctctGacccaggctgtccagctgat	10	14	1	3			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr14:20841727G>A	uc001vxe.2	-	46	6660	c.6620C>T	c.(6619-6621)TCA>TTA	p.S2207L	TEP1_uc010ahj.1_5'Flank|TEP1_uc010ahk.2_Missense_Mutation_p.S1550L|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.S2099L|TEP1_uc010tlh.1_Missense_Mutation_p.S545L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2207	WD 14.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CAGAAGCTCTGACCCAGGCTG	0.577													A	20841727	A	A	20841727	3	1	126	1	0	0	0	0	1	0	0	0	15756	1294	45	3	1303	3	TEP1	14	20841727	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08		20841727	86507813	40	8714											
BCL11B	64919	broad.mit.edu	37	chr14	99642350	99642351	+	Frame_Shift_Ins	INS	-	CA	CA													ttcatgagcggggactgcgcINScacggcctccggcccgagcg							TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr14:99642350_99642351insCA	uc001yga.2	-	4	1089_1090	c.822_823insTG	c.(820-825)GTGGCGfs	p.V274fs	BCL11B_uc001ygb.2_Frame_Shift_Ins_p.V203fs	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	274_275						nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GGGGACTGCGCCACGGCCTCCG	0.718			T	TLX3	T-ALL								CA	99642351	CA	CA	99642350	7	5	126	1	0	1	1	0	0	0	0	0	1364	739	26	0	1865	0	BCL11B	14	99642350	Frame_Shift_Ins	INS	-	TCGA-14-0740-01B-01D-1845-08	78800623	99642350	7707190	41	8715											
CASC5	57082	broad.mit.edu	37	chr15	40911168	40911168	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctaaatagggatgaacacaTtgctttctgctcccattcat	6	10	3	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr15:40911168T>G	uc010bbs.1	+	10	573	c.412T>G	c.(412-414)TTG>GTG	p.L138V	CASC5_uc010ucq.1_Intron|CASC5_uc001zme.2_Missense_Mutation_p.L112V|CASC5_uc010bbt.1_Missense_Mutation_p.L112V	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	138	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		GATGAACACATTGCTTTCTGC	0.333													G	40911168	G	G	40911168	3	3	126	1	0	0	0	0	1	0	0	0	2663	1490	52	5	446	5	CASC5	15	40911168	Missense_Mutation	SNP	T	TCGA-14-0740-01B-01D-1845-08		40911168	61620224	42	8716											
FES	2242	broad.mit.edu	37	chr15	91438682	91438682	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagagctgtgtcctgatgCcgtgttcaggctcatggagc	13	12	2	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr15:91438682C>T	uc002bpv.2	+	19	2459	c.2363C>T	c.(2362-2364)GCC>GTC	p.A788V	FES_uc010uqj.1_Missense_Mutation_p.A660V|FES_uc010uqk.1_Missense_Mutation_p.A770V|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.A647V|FES_uc002bpx.2_Missense_Mutation_p.A718V|FES_uc002bpy.2_Missense_Mutation_p.A730V	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	788	Protein kinase.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TGTCCTGATGCCGTGTTCAGG	0.632													T	91438682	T	T	91438682	3	4	126	1	0	0	0	0	1	0	0	0	5820	739	26	3	2433	3	FES	15	91438682	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	50527514	91438682	11092710	43	8717											
ADAMTS17	170691	broad.mit.edu	37	chr15	100537641	100537641	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcagtcctggccttcacaGctctgcactgccgccggccg	12	17	2	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr15:100537641G>A	uc002bvv.1	-	19	2824	c.2745C>T	c.(2743-2745)AGC>AGT	p.S915S		NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	915	TSP type-1 3.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		GGCCTTCACAGCTCTGCACTg	0.567													A	100537641	A	A	100537641	2	1	126	1	0	0	0	0	0	0	0	1	262	962	34	3		3	ADAMTS17	15	100537641	Silent	SNP	G	TCGA-14-0740-01B-01D-1845-08	9098959	100537641	1993751	44	8718											
ZKSCAN2	342357	broad.mit.edu	37	chr16	25251946	25251946	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttgcgatatttgctggggtCggtactctgggaaacaactc	12	8	1	0	rs148950715	byFrequency	TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr16:25251946C>T	uc002dod.3	-	7	2502	c.2095G>A	c.(2095-2097)GAC>AAC	p.D699N	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.D495N	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	699					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		TTGCTGGGGTCGGTACTCTGG	0.418													T	25251946	T	T	25251946	3	4	126	1	0	0	0	0	1	0	0	0	17684	884	31	2	812	2	ZKSCAN2	16	25251946	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08		25251946	65102807	45	8719											
TP53	7157	broad.mit.edu	37	chr17	7577548	7577548	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgggcctccggttcatgcCgcccatgcaggaactgttac	12	13	1	0	rs28934575		TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577548	T	T	7577548	3	4	126	1	0	0	0	0	1	0	0	0	16378	652	23	2	557	2	TP53	17	7577548	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08		7577548	73617662	46	8720											
PIRT	644139	broad.mit.edu	37	chr17	10728644	10728644	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgggcacccacaccagccCgcacaccagcatcatgagtc	9	17	1	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr17:10728644C>T	uc010col.2	-	2	614	c.319G>A	c.(319-321)GGG>AGG	p.G107R		NM_001101387	NP_001094857	P0C851	PIRT_HUMAN	phosphoinositide-interacting regulator of	107	Helical; (Potential).					integral to membrane				ovary(1)	1						CACACCAGCCCGCACACCAGC	0.527													T	10728644	T	T	10728644	3	4	126	1	0	0	0	0	1	0	0	0	11945	652	23	2	98	2	PIRT	17	10728644	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	3151096	10728644	70466566	47	8721											
CCL3	6348	broad.mit.edu	37	chr17	34416597	34416597	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaaattctgtggaatctgCcgggaggtgtagctgaagca	14	6	2	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr17:34416597C>T	uc002hkv.2	-	2	222	c.120G>A	c.(118-120)CGG>CGA	p.R40R		NM_002983	NP_002974	P10147	CCL3_HUMAN	chemokine (C-C motif) ligand 3	40		Involved in GAG binding.		R->A: Slightly reduces heparin binding.	cell-cell signaling|cellular calcium ion homeostasis|cellular component movement|cytoskeleton organization|exocytosis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|regulation of viral genome replication	extracellular space|soluble fraction	chemoattractant activity|chemokine activity|signal transducer activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTGGAATCTGCCGGGAGGTGT	0.542													T	34416597	T	T	34416597	2	4	126	1	0	0	0	0	0	0	0	1	2901	726	26	3		3	CCL3	17	34416597	Silent	SNP	C	TCGA-14-0740-01B-01D-1845-08	23687953	34416597	46778613	48	8722											
KIF18B	146909	broad.mit.edu	37	chr17	43004364	43004364	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccaaacctcacctcgcaaCgcgcttcttcttgcaggcag	7	17	3	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr17:43004364C>T	uc010wji.1	-	14	2469	c.2368G>A	c.(2368-2370)GTT>ATT	p.V790I	KIF18B_uc002iht.2_Missense_Mutation_p.V799I|KIF18B_uc010wjh.1_Missense_Mutation_p.V787I	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				CACCTCGCAACGCGCTTCTTC	0.637													T	43004364	T	T	43004364	3	4	126	1	0	0	0	0	1	0	0	0	8281	536	19	1	210	1	KIF18B	17	43004364	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	8587767	43004364	38190846	49	8723											
MUC16	94025	broad.mit.edu	37	chr19	9077406	9077406	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccctccagtagagccatgcCacatagagaattccattcca	6	14	0	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr19:9077406C>T	uc002mkp.2	-	3	10244	c.10040G>A	c.(10039-10041)TGG>TAG	p.W3347*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3348	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAGCCATGCCACATAGAGAA	0.502													T	9077406	T	T	9077406	4	4	126	1	0	0	0	0	0	1	0	0	9973	595	21	3	33811	3	MUC16	19	9077406	Nonsense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08		9077406	50051577	50	8724											
C19orf54	284325	broad.mit.edu	37	chr19	41250512	41250512	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctctttccgtggccacccGtatgagtctctccaggggga	12	14	2	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr19:41250512G>A	uc002oou.1	-	3	589	c.469C>T	c.(469-471)CGG>TGG	p.R157W	C19orf54_uc002oow.1_Missense_Mutation_p.T26M|C19orf54_uc002oox.1_RNA|C19orf54_uc002ooy.1_Missense_Mutation_p.R19W|C19orf54_uc010xvs.1_RNA	NM_198476	NP_940878	Q5BKX5	CS054_HUMAN	hypothetical protein LOC284325	157											0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GTGGCCACCCGTATGAGTCTC	0.627													A	41250512	A	A	41250512	3	1	126	1	0	0	0	0	1	0	0	0	1936	1144	40	1	602	1	C19orf54	19	41250512	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08	32173106	41250512	17878471	51	8725											
CEACAM5	1048	broad.mit.edu	37	chr19	42213611	42213611	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctcctagcctcacttctaaCcttctggaacccgcccacca	4	19	4	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr19:42213611C>A	uc002ork.2	+	2	198	c.77C>A	c.(76-78)ACC>AAC	p.T26N	CEACAM5_uc010ehz.1_Missense_Mutation_p.T26N|CEACAM5_uc002orj.1_Missense_Mutation_p.T26N|CEACAM5_uc002orl.2_Missense_Mutation_p.T26N	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	26						anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TCACTTCTAACCTTCTGGAAC	0.537													A	42213611	A	A	42213611	3	1	126	1	0	0	0	0	1	0	0	0	3195	507	18	5	83	5	CEACAM5	19	42213611	Missense_Mutation	SNP	C	TCGA-14-0740-01B-01D-1845-08	963099	42213611	16915372	52	8726											
NLRP12	91662	broad.mit.edu	37	chr19	54312882	54312882	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcctgcggagcacctcgcGcggtcttccccgtccgcgct	12	19	1	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr19:54312882G>A	uc002qch.3	-	3	2251	c.2031C>T	c.(2029-2031)CGC>CGT	p.R677R	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.R677R|NLRP12_uc002qcj.3_Silent_p.R677R|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.R677R	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	677					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGCACCTCGCGCGGTCTTCCC	0.587													A	54312882	A	A	54312882	2	1	126	1	0	0	0	0	0	0	0	1	10474	1074	38	1		1	NLRP12	19	54312882	Silent	SNP	G	TCGA-14-0740-01B-01D-1845-08	12099271	54312882	4816101	53	8727											
BCAS1	8537	broad.mit.edu	37	chr20	52570143	52570143	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatctcggctgctgacttcTtgtccttcgaggagccctct	9	14	4	1			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chr20:52570143T>C	uc002xws.2	-	11	1846	c.1508A>G	c.(1507-1509)AAG>AGG	p.K503R	BCAS1_uc010zza.1_Missense_Mutation_p.K169R|BCAS1_uc010zzb.1_Missense_Mutation_p.K429R|BCAS1_uc010gim.2_Missense_Mutation_p.K359R|BCAS1_uc002xwt.2_Missense_Mutation_p.K489R|BCAS1_uc010gil.1_Missense_Mutation_p.K425R	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	503						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TGCTGACTTCTTGTCCTTCGA	0.537													C	52570143	C	C	52570143	3	2	126	1	0	0	0	0	1	0	0	0	1350	1609	56	4	254	4	BCAS1	20	52570143	Missense_Mutation	SNP	T	TCGA-14-0740-01B-01D-1845-08		52570143	10455377	54	8728											
GRPR	2925	broad.mit.edu	37	chrX	16142166	16142166	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cacagtgcggatctccccgtGaacgatgactggtcccaccc	10	16	1	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chrX:16142166G>A	uc004cxj.2	+	1	743	c.90G>A	c.(88-90)GTG>GTA	p.V30V		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	30	Extracellular (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					ATCTCCCCGTGAACGATGACT	0.478											OREG0019682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	16142166	A	A	16142166	2	1	126	1	0	0	0	0	0	0	0	1	6808	1277	45	3		3	GRPR	23	16142166	Silent	SNP	G	TCGA-14-0740-01B-01D-1845-08		16142166	139128394	55	8729											
FOXR2	139628	broad.mit.edu	37	chrX	55650332	55650332	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccagaaatgcctcagaagaGgagacccagtcctgatggag	12	11	1	5			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chrX:55650332G>C	uc004duo.2	+	1	500	c.188G>C	c.(187-189)AGG>ACG	p.R63T		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	63					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						CCTCAGAAGAGGAGACCCAGT	0.537													C	55650332	C	C	55650332	3	2	126	1	0	0	0	0	1	0	0	0	6032	1000	35	5	190	5	FOXR2	23	55650332	Missense_Mutation	SNP	G	TCGA-14-0740-01B-01D-1845-08	39508166	55650332	99620228	56	8730											
MAGEA5	4104	broad.mit.edu	37	chrX	151283896	151283896	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accagaggagaggaggaggaCacagcctcctgctcctcagt	13	12	1	2			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chrX:151283896C>T	uc004ffj.2	-	3	322	c.117G>A	c.(115-117)GTG>GTA	p.V39V		NM_021049	NP_066387	P43359	MAGA5_HUMAN	melanoma antigen family A, 5	39	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGGAGGACACAGCCTCCT	0.647													T	151283896	T	T	151283896	2	4	126	1	0	0	0	0	0	0	0	1	9169	465	17	3		3	MAGEA5	23	151283896	Silent	SNP	C	TCGA-14-0740-01B-01D-1845-08	95633564	151283896	3986664	57	8731											
OPN1MW	2652	broad.mit.edu	37	chrX	153490645	153490645	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgggccaccctatgtgtgtCctggagggctacaccgtctc	12	14	1	0			TCGA-14-0740-01B-01D-1845-08	TCGA-14-0740-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f49859c4-adf9-4c53-8288-8a7ad65a940d	36ba7e2f-dcc9-4046-b7e7-a9e4c732841d	g.chrX:153490645C>T	uc004fkd.2	+	2	463	c.381C>T	c.(379-381)GTC>GTT	p.V127V		NM_000513	NP_000504	P04001	OPSG_HUMAN	opsin 1 (cone pigments), medium-wave-sensitive	127	Extracellular.				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTATGTGTGTCCTGGAGGGCT	0.617													T	153490645	T	T	153490645	2	4	126	1	0	0	0	0	0	0	0	1	10878	842	30	3		3	OPN1MW	23	153490645	Silent	SNP	C	TCGA-14-0740-01B-01D-1845-08	2206749	153490645	1779915	58	8732											
ASPM	259266	broad.mit.edu	37	chr1	197071366	197071366	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaagtagactggatgaaagTagcagccctgtgcatctctc	11	9	1	2			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr1:197071366T>G	uc001gtu.2	-	18	7272	c.7015A>C	c.(7015-7017)ACT>CCT	p.T2339P	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.T187P	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2339	IQ 22.|IQ 23.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TGGATGAAAGTAGCAGCCCTG	0.408													G	197071366	G	G	197071366	3	3	127	1	0	0	0	0	1	0	0	0	1056	1638	57	5	3462	5	ASPM	1	197071366	Missense_Mutation	SNP	T	TCGA-14-0781-01B-01D-1696-08		197071366	52179255	1	8733											
RRP15	51018	broad.mit.edu	37	chr1	218478415	218478415	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgatgtgcagagtaaagccaGatgttgtccaagacaaagag	12	6	0	5			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr1:218478415G>A	uc001hlj.2	+	3	481	c.451G>A	c.(451-453)GAT>AAT	p.D151N		NM_016052	NP_057136	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog	151						mitochondrion|nucleolus	protein binding				0				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		AGTAAAGCCAGATGTTGTCCA	0.363													A	218478415	A	A	218478415	3	1	127	1	0	0	0	0	1	0	0	0	13687	942	33	3	461	3	RRP15	1	218478415	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08	21407049	218478415	30772206	2	8734											
APOB	338	broad.mit.edu	37	chr2	21238335	21238335	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggcaggcgaccagtgggCgaggatctcacttctggctt	14	10	2	0			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr2:21238335C>T	uc002red.2	-	22	3543	c.3415G>A	c.(3415-3417)GCC>ACC	p.A1139T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1139					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACCAGTGGGCGAGGATCTCA	0.463													T	21238335	T	T	21238335	3	4	127	1	0	0	0	0	1	0	0	0	785	768	27	1	10308	1	APOB	2	21238335	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08		21238335	221961038	3	8735											
SDPR	8436	broad.mit.edu	37	chr2	192711670	192711670	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggctaggcaggtgggaacGttctttctctctgggagctg	15	8	3	0			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr2:192711670G>A	uc002utb.2	-	1	312	c.-18C>T	c.(-20--16)AACGT>AATGT			NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein							caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	AGGTGGGAACGTTCTTTCTCT	0.617													A	192711670	A	A	192711670	1	1	127	1	0	0	0	0	0	0	0	0	13970	1160	40	1		1	SDPR	2	192711670	Translation_Start_Site	SNP	G	TCGA-14-0781-01B-01D-1696-08	171473335	192711670	50487703	4	8736											
ALS2CR11	151254	broad.mit.edu	37	chr2	202483659	202483659	+	Frame_Shift_Del	DEL	G	-	-													ccggtgccctcctggttcttGttcttaggcagggccgtcgt							TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr2:202483659delG	uc002uye.2	-	1	243	c.195delC	c.(193-195)AACfs	p.N65fs	ALS2CR11_uc002uyf.2_Frame_Shift_Del_p.N65fs|ALS2CR11_uc010fti.2_Frame_Shift_Del_p.N65fs	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	65										large_intestine(1)|ovary(1)|skin(1)	3						CCTGGTTCTTGTTCTTAGGCA	0.657													-	202483659	-	-	202483659	7	5	127	1	0	1	0	1	0	0	0	0	552	1368	48	0	5478	0	ALS2CR11	2	202483659	Frame_Shift_Del	DEL	G	TCGA-14-0781-01B-01D-1696-08	9771989	202483659	40715714	5	8737											
UNC5C	8633	broad.mit.edu	37	chr4	96127874	96127874	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catagtgaggacgactgggcGggtgagcagagctcctgggg	19	8	0	3	rs139568380	byFrequency	TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr4:96127874G>A	uc003htp.1	-	11	1961	c.1807C>T	c.(1807-1809)CGC>TGC	p.R603C	UNC5C_uc010ilc.1_Missense_Mutation_p.R622C	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	603	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		ACGACTGGGCGGGTGAGCAGA	0.582													A	96127874	A	A	96127874	3	1	127	1	0	0	0	0	1	0	0	0	16990	1116	39	2	1012	2	UNC5C	4	96127874	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08		96127874	95026402	6	8738											
AHRR	57491	broad.mit.edu	37	chr5	422882	422882	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacatttatgactacatccaCgtggacgaccgccaggactt	8	12	0	1	rs2671894	byFrequency	TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr5:422882C>T	uc003jav.2	+	6	536	c.492C>T	c.(490-492)CAC>CAT	p.H164H	AHRR_uc003jaw.2_Silent_p.H160H|AHRR_uc010isy.2_Silent_p.H10H|AHRR_uc010isz.2_Silent_p.H160H|AHRR_uc003jax.2_Translation_Start_Site|AHRR_uc003jay.2_Silent_p.H20H	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	164	PAS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			ACTACATCCACGTGGACGACC	0.547													T	422882	T	T	422882	2	4	127	1	0	0	0	0	0	0	0	1	417	535	19	1		1	AHRR	5	422882	Silent	SNP	C	TCGA-14-0781-01B-01D-1696-08		422882	180492378	7	8739											
CARD6	84674	broad.mit.edu	37	chr5	40853877	40853877	+	Frame_Shift_Del	DEL	T	-	-													gatgtcactcgaatggaacaTttgggagactgccaagaccc							TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr5:40853877delT	uc003jmg.2	+	3	2518	c.2443delT	c.(2443-2445)TTTfs	p.F815fs		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	815					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						GAATGGAACATTTGGGAGACT	0.453													-	40853877	-	-	40853877	7	5	127	1	0	1	0	1	0	0	0	0	2650	1493	52	0	2453	0	CARD6	5	40853877	Frame_Shift_Del	DEL	T	TCGA-14-0781-01B-01D-1696-08	40430995	40853877	140061383	8	8740											
HCN1	348980	broad.mit.edu	37	chr5	45262241	45262241	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgttccggggaccgccgtcaCgggttgagggatggaggcca	18	11	1	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr5:45262241C>T	uc003jok.2	-	8	2480	c.2455G>A	c.(2455-2457)GTG>ATG	p.V819M		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	819	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ACCGCCGTCACGGGTTGAGGG	0.677													T	45262241	T	T	45262241	3	4	127	1	0	0	0	0	1	0	0	0	6996	536	19	1	221	1	HCN1	5	45262241	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08	4408364	45262241	135653019	9	8741											
DMGDH	29958	broad.mit.edu	37	chr5	78326739	78326739	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaacttgccaaatggtgataGgtcagttaccgctactcttt	8	9	2	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr5:78326739G>T	uc003kfs.2	-	10	1606	c.1600C>A	c.(1600-1602)CTA>ATA	p.L534I	DMGDH_uc011cte.1_Missense_Mutation_p.L384I|DMGDH_uc011ctf.1_Missense_Mutation_p.L333I|DMGDH_uc011ctg.1_Missense_Mutation_p.L154I	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	534					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		AATGGTGATAGGTCAGTTACC	0.433													T	78326739	T	T	78326739	3	4	127	1	0	0	0	0	1	0	0	0	4581	991	35	5	1028	5	DMGDH	5	78326739	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08	33064498	78326739	102588521	10	8742											
GCNT2	2651	broad.mit.edu	37	chr6	10529185	10529186	+	Frame_Shift_Del	DEL	TT	-	-													ctgtctttttagcgcgtctcTtatctctgccctgatttttg							TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr6:10529185_10529186delTT	uc010joo.2	+	3	592_593	c.41_42delTT	c.(40-42)CTTfs	p.L14fs	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Frame_Shift_Del_p.L13fs|GCNT2_uc010jon.2_Frame_Shift_Del_p.L13fs	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	14	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AGCGCGTCTCTTATCTCTGCCC	0.401													-	10529186	-	-	10529185	7	5	127	1	0	1	0	1	0	0	0	0	6301	1609	56	0	43	0	GCNT2	6	10529185	Frame_Shift_Del	DEL	TT	TCGA-14-0781-01B-01D-1696-08		10529185	160585882	11	8743											
LAMA2	3908	broad.mit.edu	37	chr6	129823804	129823804	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctcctgggtattttacagGgtccttgtgctgcagaatca	10	10	2	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr6:129823804G>A	uc003qbn.2	+	58	8350	c.8245G>A	c.(8245-8247)GGT>AGT	p.G2749S	LAMA2_uc003qbo.2_Missense_Mutation_p.G2745S|uc003qbq.2_RNA	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2749					cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TATTTTACAGGGTCCTTGTGC	0.388													A	129823804	A	A	129823804	3	1	127	1	0	0	0	0	1	0	0	0	8606	1246	43	3	8479	3	LAMA2	6	129823804	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08	119294619	129823804	41291263	12	8744											
PHACTR2	9749	broad.mit.edu	37	chr6	144086812	144086812	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccagttgtcctcgtcagcgTtggagctgacctgcccgtct	11	14	2	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr6:144086812T>C	uc003qjq.3	+	6	1206	c.1076T>C	c.(1075-1077)GTT>GCT	p.V359A	PHACTR2_uc010khh.2_Missense_Mutation_p.V279A|PHACTR2_uc010khi.2_Missense_Mutation_p.V370A|PHACTR2_uc003qjr.3_Missense_Mutation_p.V290A	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	359							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		CTCGTCAGCGTTGGAGCTGAC	0.582													C	144086812	C	C	144086812	3	2	127	1	0	0	0	0	1	0	0	0	11810	1725	60	4	1148	4	PHACTR2	6	144086812	Missense_Mutation	SNP	T	TCGA-14-0781-01B-01D-1696-08	14263008	144086812	27028255	13	8745											
SERAC1	84947	broad.mit.edu	37	chr6	158579375	158579375	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attcttctgcaacagatgacGcaataagcagccagggacat	9	10	2	2	rs139301835	byFrequency	TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr6:158579375G>A	uc003qrc.2	-	2	163	c.21C>T	c.(19-21)TGC>TGT	p.C7C	SERAC1_uc003qrb.2_5'UTR	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	7					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		AACAGATGACGCAATAAGCAG	0.358													A	158579375	A	A	158579375	2	1	127	1	0	0	0	0	0	0	0	1	14074	1079	38	1		1	SERAC1	6	158579375	Silent	SNP	G	TCGA-14-0781-01B-01D-1696-08	14492563	158579375	12535692	14	8746											
PCLO	27445	broad.mit.edu	37	chr7	82579939	82579939	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtggagaagcagttccagaaGggtcatagttatactggtag	14	5	1	2			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr7:82579939G>T	uc003uhx.2	-	6	10254	c.9965C>A	c.(9964-9966)CCT>CAT	p.P3322H	PCLO_uc003uhv.2_Missense_Mutation_p.P3322H|PCLO_uc010lec.2_Missense_Mutation_p.P287H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3253					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGTTCCAGAAGGGTCATAGTT	0.478													T	82579939	T	T	82579939	3	4	127	1	0	0	0	0	1	0	0	0	11583	1000	35	5	5560	5	PCLO	7	82579939	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08		82579939	76558724	15	8747											
EPHB4	2050	broad.mit.edu	37	chr7	100411279	100411279	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	attagggcaacccaccatgtCcgatgagatactgtccgtgt	10	11	0	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr7:100411279C>T	uc003uwn.1	-	10	2242	c.1751G>A	c.(1750-1752)GGA>GAA	p.G584E	EPHB4_uc003uwm.1_Missense_Mutation_p.G491E|EPHB4_uc010lhj.1_Missense_Mutation_p.G584E	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	584	Cytoplasmic (Potential).				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCCACCATGTCCGATGAGATA	0.343													T	100411279	T	T	100411279	3	4	127	1	0	0	0	0	1	0	0	0	5177	855	30	3	1244	3	EPHB4	7	100411279	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08	17831340	100411279	58727384	16	8748											
CADPS2	93664	broad.mit.edu	37	chr7	121960313	121960313	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcctcctctactgttaaaCgtctgtgcacagtatcataa	7	11	3	0			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr7:121960313C>T	uc010lkp.2	-	29	3960	c.3797G>A	c.(3796-3798)CGT>CAT	p.R1266H	CADPS2_uc011knx.1_Missense_Mutation_p.R641H|CADPS2_uc003vkg.3_Missense_Mutation_p.R920H|CADPS2_uc010lkq.2_Missense_Mutation_p.R1225H	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	1266					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TACTGTTAAACGTCTGTGCAC	0.433													T	121960313	T	T	121960313	3	4	127	1	0	0	0	0	1	0	0	0	2571	536	19	1	97	1	CADPS2	7	121960313	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08	21549034	121960313	37178350	17	8749											
FREM1	158326	broad.mit.edu	37	chr9	14824887	14824887	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	taaaatgtagctgtttcttaGttatataggccacctcagtt	7	7	2	0			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr9:14824887G>C	uc003zlm.2	-	11	2575	c.1985C>G	c.(1984-1986)ACT>AGT	p.T662S	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	662	CSPG 4.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CTGTTTCTTAGTTATATAGGC	0.428													C	14824887	C	C	14824887	3	2	127	1	0	0	0	0	1	0	0	0	6044	1029	36	5	4712	5	FREM1	9	14824887	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08		14824887	126388544	18	8750											
CRB2	286204	broad.mit.edu	37	chr9	126136965	126136965	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctgcctggagggtcttgCtggccagaggtgggtctggg	19	9	2	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr9:126136965C>T	uc004bnx.1	+	11	3589	c.3497C>T	c.(3496-3498)GCT>GTT	p.A1166V		NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	1166	Extracellular (Potential).|EGF-like 14.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GAGGGTCTTGCTGGCCAGAGG	0.657													T	126136965	T	T	126136965	3	4	127	1	0	0	0	0	1	0	0	0	3849	797	28	3	3539	3	CRB2	9	126136965	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08	111312078	126136965	15076466	19	8751											
PTEN	5728	broad.mit.edu	37	chr10	89711891	89711891	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagggagtaactattcccaGtcagaggcgctatgtgtatt	11	9	1	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr10:89711891G>A	uc001kfb.2	+	7	1540	c.509G>A	c.(508-510)AGT>AAT	p.S170N		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	170	Phosphatase tensin-type.		S -> N (loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|S -> R (in BZS; severely reduced protein phosphatase activity; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.S170N(3)|p.S170I(3)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.V166fs*10(1)|p.G165_K342del(1)|p.G165_*404del(1)|p.S170fs*13(1)|p.S170G(1)|p.S170fs*8(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ACTATTCCCAGTCAGAGGCGC	0.353		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89711891	A	A	89711891	3	1	127	1	0	0	0	0	1	0	0	0	12738	1029	36	3	531	3	PTEN	10	89711891	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08		89711891	45822856	20	8752											
SLC22A10	387775	broad.mit.edu	37	chr11	63069908	63069908	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agctgtcgctctcatagttcGatgtcttgctcttttgacac	8	11	3	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr11:63069908G>A	uc009yor.2	+	7	1386	c.1178G>A	c.(1177-1179)CGA>CAA	p.R393Q	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_Intron|SLC22A10_uc010rmp.1_Intron	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	393	Helical; (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						CTCATAGTTCGATGTCTTGCT	0.438													A	63069908	A	A	63069908	3	1	127	1	0	0	0	0	1	0	0	0	14441	1058	37	2	1204	2	SLC22A10	11	63069908	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08		63069908	71936608	21	8753											
NAALADL1	10004	broad.mit.edu	37	chr11	64821985	64821985	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaggaattgggggaaatcCggagacattggcaaggtcca	15	6	0	1	rs138766443		TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr11:64821985C>T	uc001ocn.2	-	5	845	c.829G>A	c.(829-831)GGA>AGA	p.G277R	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	277	NAALADase.|Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						GGGGGAAATCCGGAGACATTG	0.597													T	64821985	T	T	64821985	3	4	127	1	0	0	0	0	1	0	0	0	10129	661	23	2	1449	2	NAALADL1	11	64821985	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08	1752077	64821985	70184531	22	8754											
UNC93B1	81622	broad.mit.edu	37	chr11	67765220	67765220	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttccgctccgcgggagcgtCcgcagaaccgtcttgttgaa	12	13	1	2			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr11:67765220C>T	uc001omw.1	-	7	911	c.831G>A	c.(829-831)CGG>CGA	p.R277R		NM_030930	NP_112192	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1	277					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome					0						GCGGGAGCGTCCGCAGAACCG	0.652													T	67765220	T	T	67765220	2	4	127	1	0	0	0	0	0	0	0	1	16994	842	30	3		3	UNC93B1	11	67765220	Silent	SNP	C	TCGA-14-0781-01B-01D-1696-08	2943235	67765220	67241296	23	8755											
MMP10	4319	broad.mit.edu	37	chr11	102646042	102646042	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggttccagtgggatcttcGccaaaaatatctgtaataca	9	8	2	0	rs150825082	byFrequency	TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr11:102646042G>A	uc001phg.1	-	7	965	c.943C>T	c.(943-945)CGA>TGA	p.R315*		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	315	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		TGGGATCTTCGCCAAAAATAT	0.333													A	102646042	A	A	102646042	4	1	127	1	0	0	0	0	0	1	0	0	9649	1095	38	1	503	1	MMP10	11	102646042	Nonsense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08	34880822	102646042	32360474	24	8756											
KCNA1	3736	broad.mit.edu	37	chr12	5020794	5020794	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaacgagtacttcttcgacCgcaaccggcccagcttcgac	10	15	1	0			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr12:5020794C>T	uc001qnh.2	+	2	1355	c.250C>T	c.(250-252)CGC>TGC	p.R84C		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	84					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTTCTTCGACCGCAACCGGCC	0.627													T	5020794	T	T	5020794	3	4	127	1	0	0	0	0	1	0	0	0	8001	652	23	2	252	2	KCNA1	12	5020794	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08		5020794	128831101	25	8757											
C12orf63	374467	broad.mit.edu	37	chr12	97085019	97085019	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagatagatacagggctgaCatttgctctgtaattgcaag	10	7	2	3			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr12:97085019C>T	uc001tet.1	+	11	1548	c.1470C>T	c.(1468-1470)GAC>GAT	p.D490D		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	490										skin(6)|ovary(1)	7						ACAGGGCTGACATTTGCTCTG	0.358													T	97085019	T	T	97085019	2	4	127	1	0	0	0	0	0	0	0	1	1706	477	17	3		3	C12orf63	12	97085019	Silent	SNP	C	TCGA-14-0781-01B-01D-1696-08	92064225	97085019	36766876	26	8758											
PCDH20	64881	broad.mit.edu	37	chr13	61986212	61986212	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gttcaccacagagagggcgaCccatccatttcgtccagcgt	10	14	1	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr13:61986212C>G	uc001vid.3	-	2	2384	c.2020G>C	c.(2020-2022)GTC>CTC	p.V674L	PCDH20_uc010thj.1_Missense_Mutation_p.V674L	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	647	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GAGAGGGCGACCCATCCATTT	0.458													G	61986212	G	G	61986212	3	3	127	1	0	0	0	0	1	0	0	0	11515	507	18	5	839	5	PCDH20	13	61986212	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08		61986212	53183666	27	8759											
LRFN5	145581	broad.mit.edu	37	chr14	42355895	42355895	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagctcagatctgtccaaagCgttgtgtctgtcagattttg	10	8	4	2			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr14:42355895C>T	uc001wvm.2	+	3	1265	c.67C>T	c.(67-69)CGT>TGT	p.R23C	LRFN5_uc010ana.2_Missense_Mutation_p.R23C	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	23	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CTGTCCAAAGCGTTGTGTCTG	0.398										HNSCC(30;0.082)			T	42355895	T	T	42355895	3	4	127	1	0	0	0	0	1	0	0	0	8941	768	27	1	69	1	LRFN5	14	42355895	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08		42355895	64993645	28	8760											
GPR65	8477	broad.mit.edu	37	chr14	88478097	88478097	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acaggaagatatgatatgtgGaatatattaaaattctgcac	8	4	1	2			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr14:88478097G>A	uc001xvv.2	+	2	1436	c.906G>A	c.(904-906)TGG>TGA	p.W302*		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	302	Cytoplasmic (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						ATGATATGTGGAATATATTAA	0.343													A	88478097	A	A	88478097	4	1	127	1	0	0	0	0	0	1	0	0	6706	1183	41	3	908	3	GPR65	14	88478097	Nonsense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08	46122202	88478097	18871443	29	8761											
IGF1R	3480	broad.mit.edu	37	chr15	99454571	99454571	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tgacgtcctgcatttcacctCcaccaccacgtcgaagaatc	6	16	1	2			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr15:99454571C>G	uc002bul.2	+	7	1540	c.1490C>G	c.(1489-1491)TCC>TGC	p.S497C	IGF1R_uc010urq.1_Missense_Mutation_p.S497C|IGF1R_uc010bon.2_Missense_Mutation_p.S497C|IGF1R_uc010urr.1_5'UTR	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	497	Fibronectin type-III 1.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CATTTCACCTCCACCACCACG	0.522													G	99454571	G	G	99454571	3	3	127	1	0	0	0	0	1	0	0	0	7571	855	30	5	1516	5	IGF1R	15	99454571	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08		99454571	3076821	30	8762											
LRRK1	79705	broad.mit.edu	37	chr15	101595206	101595206	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caaaaaatagcctaccagatCgcctcgggcctggcctacct	8	15	0	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr15:101595206C>T	uc002bwr.2	+	27	4429	c.4110C>T	c.(4108-4110)ATC>ATT	p.I1370I	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1370	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCTACCAGATCGCCTCGGGCC	0.438													T	101595206	T	T	101595206	2	4	127	1	0	0	0	0	0	0	0	1	9032	874	31	2		2	LRRK1	15	101595206	Silent	SNP	C	TCGA-14-0781-01B-01D-1696-08	2140635	101595206	936186	31	8763											
JMJD5	79831	broad.mit.edu	37	chr16	27225037	27225037	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcccgtgatcctgaaaggCgtggctgaccactggccgtg	15	12	0	3			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr16:27225037C>T	uc002doh.2	+	3	812	c.630C>T	c.(628-630)GGC>GGT	p.G210G	JMJD5_uc010vcn.1_Silent_p.G248G|JMJD5_uc010bxw.2_Intron|JMJD5_uc010bxx.2_5'Flank	NM_024773	NP_079049	Q8N371	KDM8_HUMAN	jumonji domain containing 5 isoform 2	210					G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(2)|upper_aerodigestive_tract(1)	3						TCCTGAAAGGCGTGGCTGACC	0.582													T	27225037	T	T	27225037	2	4	127	1	0	0	0	0	0	0	0	1	7952	755	27	1		1	JMJD5	16	27225037	Silent	SNP	C	TCGA-14-0781-01B-01D-1696-08		27225037	63129716	32	8764											
CHST5	23563	broad.mit.edu	37	chr16	75564022	75564022	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctccatcaggtagaagacGtcggggtgctggctgaagag	17	8	1	4			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr16:75564022G>A	uc002fei.2	-	3	1656	c.261C>T	c.(259-261)GAC>GAT	p.D87D	CHST5_uc002fej.1_Silent_p.D93D	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	87	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GGTAGAAGACGTCGGGGTGCT	0.672													A	75564022	A	A	75564022	2	1	127	1	0	0	0	0	0	0	0	1	3407	1136	40	1		1	CHST5	16	75564022	Silent	SNP	G	TCGA-14-0781-01B-01D-1696-08	48338985	75564022	14790731	33	8765											
MED13	9969	broad.mit.edu	37	chr17	60107352	60107352	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actgaagaaaatttgacccaCttctggacagactgaggatc	9	9	1	5			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr17:60107352C>G	uc002izo.2	-	7	1109	c.1032G>C	c.(1030-1032)AAG>AAC	p.K344N	MED13_uc002izp.2_5'UTR	NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	344					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						ATTTGACCCACTTCTGGACAG	0.363													G	60107352	G	G	60107352	3	3	127	1	0	0	0	0	1	0	0	0	9430	564	20	5	5588	5	MED13	17	60107352	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08		60107352	21087858	34	8766											
LAMA1	284217	broad.mit.edu	37	chr18	7011417	7011417	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtagtaaaccccctcggtcGtgcccctcaagttactctga	9	14	2	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr18:7011417G>A	uc002knm.2	-	25	3663	c.3569C>T	c.(3568-3570)ACG>ATG	p.T1190M	LAMA1_uc010wzj.1_Missense_Mutation_p.T666M	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1190	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCCTCGGTCGTGCCCCTCAA	0.597													A	7011417	A	A	7011417	3	1	127	1	0	0	0	0	1	0	0	0	8605	1145	40	1	5814	1	LAMA1	18	7011417	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08		7011417	71065831	35	8767											
MUC16	94025	broad.mit.edu	37	chr19	9088981	9088981	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtctgtgacattgttgccGtcccagtgaggtgagatatt	13	7	1	3			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr19:9088981G>A	uc002mkp.2	-	1	3038	c.2834C>T	c.(2833-2835)ACG>ATG	p.T945M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	945	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CATTGTTGCCGTCCCAGTGAG	0.478													A	9088981	A	A	9088981	3	1	127	1	0	0	0	0	1	0	0	0	9973	1145	40	1	41025	1	MUC16	19	9088981	Missense_Mutation	SNP	G	TCGA-14-0781-01B-01D-1696-08		9088981	50040002	36	8768											
FCGBP	8857	broad.mit.edu	37	chr19	40376645	40376645	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actcacgacagaaagtttcaTtcctccagggctccacgtgg	9	13	2	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr19:40376645T>G	uc002omp.3	-	24	11785	c.11777A>C	c.(11776-11778)AAT>ACT	p.N3926T		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	3926						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAAAGTTTCATTCCTCCAGGG	0.627													G	40376645	G	G	40376645	3	3	127	1	0	0	0	0	1	0	0	0	5778	1493	52	5	4492	5	FCGBP	19	40376645	Missense_Mutation	SNP	T	TCGA-14-0781-01B-01D-1696-08	31287664	40376645	18752338	37	8769											
PFKL	5211	broad.mit.edu	37	chr21	45732952	45732952	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgacttctgcggcaccgaCatgaccatcggcacggactc	10	15	1	1			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr21:45732952C>T	uc002zel.2	+	5	578	c.519C>T	c.(517-519)GAC>GAT	p.D173D	PFKL_uc002zek.2_Silent_p.D220D|PFKL_uc011afd.1_Silent_p.D220D	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	173					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		GCGGCACCGACATGACCATCG	0.632													T	45732952	T	T	45732952	2	4	127	1	0	0	0	0	0	0	0	1	11764	477	17	3		3	PFKL	21	45732952	Silent	SNP	C	TCGA-14-0781-01B-01D-1696-08		45732952	2396943	38	8770											
PARVB	29780	broad.mit.edu	37	chr22	44536022	44536022	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aggatgatgatgggccggttCggtaagtaaccccagggaaa	15	7	0	2	rs149571024		TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chr22:44536022C>T	uc003ben.2	+	8	763	c.711C>T	c.(709-711)TTC>TTT	p.F237F	PARVB_uc003bem.2_Silent_p.F270F|PARVB_uc010gzn.2_Silent_p.F185F|PARVB_uc003beo.2_Silent_p.F200F	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	237					cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				TGGGCCGGTTCGGTAAGTAAC	0.532													T	44536022	T	T	44536022	2	4	127	1	0	0	0	0	0	0	0	1	11469	898	31	2		2	PARVB	22	44536022	Silent	SNP	C	TCGA-14-0781-01B-01D-1696-08		44536022	6768544	39	8771											
GATA1	2623	broad.mit.edu	37	chrX	48650419	48650419	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctggatggaaaaggcagcaCcagcttcctggagactttga	12	9	1	2			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chrX:48650419C>A	uc004dkq.3	+	3	480	c.389C>A	c.(388-390)ACC>AAC	p.T130N		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	130					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						AAAGGCAGCACCAGCTTCCTG	0.602			Mis|F		megakaryoblastic leukemia of Downs Syndrome								A	48650419	A	A	48650419	3	1	127	1	0	0	0	0	1	0	0	0	6253	507	18	5	395	5	GATA1	23	48650419	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08		48650419	106620141	40	8772											
ACTRT1	139741	broad.mit.edu	37	chrX	127185485	127185485	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgctcccaggacctctcccCggctcttgcgtagctctttc	8	17	3	0			TCGA-14-0781-01B-01D-1696-08	TCGA-14-0781-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	13878ec6-fce7-423e-b545-6656145e9d2c	59932204-ddef-439f-8b64-e40f5605827c	g.chrX:127185485C>T	uc004eum.2	-	1	898	c.701G>A	c.(700-702)CGG>CAG	p.R234Q		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	234						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						GACCTCTCCCCGGCTCTTGCG	0.507													T	127185485	T	T	127185485	3	4	127	1	0	0	0	0	1	0	0	0	218	652	23	2	433	2	ACTRT1	23	127185485	Missense_Mutation	SNP	C	TCGA-14-0781-01B-01D-1696-08	78535066	127185485	28085075	41	8773											
WDR8	49856	broad.mit.edu	37	chr1	3548093	3548093	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggtagagcctgctgcctcCcgtgcagatggccagccgcg	14	15	0	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:3548093C>T	uc001ako.2	-	11	1285	c.1177G>A	c.(1177-1179)GGA>AGA	p.G393R	WDR8_uc001akn.3_Missense_Mutation_p.G393R	NM_017818	NP_060288	Q9P2S5	WRP73_HUMAN	WD repeat domain 8	393	WD 6.					centrosome	protein binding				0	all_cancers(77;0.0128)|all_epithelial(69;0.00526)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;4.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.16e-22)|GBM - Glioblastoma multiforme(42;1.05e-14)|Colorectal(212;1.19e-05)|BRCA - Breast invasive adenocarcinoma(365;2.67e-05)|COAD - Colon adenocarcinoma(227;5.82e-05)|Kidney(185;0.000364)|KIRC - Kidney renal clear cell carcinoma(229;0.00223)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CTGCTGCCTCCCGTGCAGATG	0.667													T	3548093	T	T	3548093	3	4	128	1	0	0	0	0	1	0	0	0	17326	632	22	3	213	3	WDR8	1	3548093	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08		3548093	245702528	1	8774											
OMA1	115209	broad.mit.edu	37	chr1	58946683	58946683	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtatgttaatggtatttgcTcctgtttttgaataggaaga	10	3	0	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:58946683T>C	uc001cyy.2	-	9	1617	c.1529A>G	c.(1528-1530)GAG>GGG	p.E510G	DAB1_uc001cyt.1_Intron|OMA1_uc001cyx.1_Intron	NM_145243	NP_660286	Q96E52	OMA1_HUMAN	OMA1 homolog, zinc metallopeptidase precursor	510					proteolysis	integral to membrane|mitochondrial membrane	metal ion binding|metalloendopeptidase activity			large_intestine(1)	1	all_cancers(7;6.54e-05)					TGGTATTTGCTCCTGTTTTTG	0.328													C	58946683	C	C	58946683	3	2	128	1	0	0	0	0	1	0	0	0	10864	1551	54	4	49	4	OMA1	1	58946683	Missense_Mutation	SNP	T	TCGA-14-0786-01B-01D-1492-08	55398590	58946683	190303938	2	8775											
GJA8	2703	broad.mit.edu	37	chr1	147380346	147380346	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcatcttcgtctccaccccGtccctgatgtacgtggggca	9	15	3	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:147380346G>A	uc001epu.1	+	2	327	c.264G>A	c.(262-264)CCG>CCA	p.P88P		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	88	Helical; (Potential).		P -> S (in CZP1).		cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					TCTCCACCCCGTCCCTGATGT	0.642													A	147380346	A	A	147380346	2	1	128	1	0	0	0	0	0	0	0	1	6405	1132	40	1		1	GJA8	1	147380346	Silent	SNP	G	TCGA-14-0786-01B-01D-1492-08	88433663	147380346	101870275	3	8776											
LAMB3	3914	broad.mit.edu	37	chr1	209803992	209803992	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcgtcctggccctccgccGgtctccagggccggttgttg	16	15	1	0	rs114394307	by1000genomes	TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:209803992G>A	uc001hhg.2	-	8	1301	c.911C>T	c.(910-912)CCG>CTG	p.P304L	LAMB3_uc009xco.2_Missense_Mutation_p.P304L|LAMB3_uc001hhh.2_Missense_Mutation_p.P304L|LAMB3_uc010psl.1_RNA|LAMB3_uc009xcp.1_Missense_Mutation_p.P240L	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	304	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GCCCTCCGCCGGTCTCCAGGG	0.622													A	209803992	A	A	209803992	3	1	128	1	0	0	0	0	1	0	0	0	8612	1116	39	2	2667	2	LAMB3	1	209803992	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08	62423646	209803992	39446629	4	8777											
RYR2	6262	broad.mit.edu	37	chr1	237774131	237774131	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgtgccgcagtgccccccgCgcctccacgtgcagttcctg	11	20	0	0			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr1:237774131C>T	uc001hyl.1	+	36	4873	c.4753C>T	c.(4753-4755)CGC>TGC	p.R1585C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1585	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTGCCCCCCGCGCCTCCACGT	0.537													T	237774131	T	T	237774131	3	4	128	1	0	0	0	0	1	0	0	0	13769	768	27	1	4895	1	RYR2	1	237774131	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08	27970139	237774131	11476490	5	8778											
CAD	790	broad.mit.edu	37	chr2	27465785	27465785	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgctgcctgacactgatgtgCtctacatgactcgaatccag	9	13	1	3			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr2:27465785C>A	uc002rji.2	+	42	6586	c.6424C>A	c.(6424-6426)CTC>ATC	p.L2142I	CAD_uc010eyw.2_Missense_Mutation_p.L2079I	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	2142	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CACTGATGTGCTCTACATGAC	0.582													A	27465785	A	A	27465785	3	1	128	1	0	0	0	0	1	0	0	0	2565	797	28	5	6590	5	CAD	2	27465785	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08		27465785	215733588	6	8779											
PRKD3	23683	broad.mit.edu	37	chr2	37501816	37501816	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atctcgtggtgaagatatgcGgagaatttctgaaagtggaa	13	4	2	4			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr2:37501816G>C	uc002rqd.2	-	10	1954	c.1399C>G	c.(1399-1401)CGC>GGC	p.R467G	PRKD3_uc002rqe.1_Missense_Mutation_p.R67G|PRKD3_uc002rqf.1_Missense_Mutation_p.R467G	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	467	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				GAAGATATGCGGAGAATTTCT	0.318													C	37501816	C	C	37501816	3	2	128	1	0	0	0	0	1	0	0	0	12520	1116	39	5	1309	5	PRKD3	2	37501816	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08	10036031	37501816	205697557	7	8780											
ST6GAL2	84620	broad.mit.edu	37	chr2	107460204	107460204	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcgcggggcagcgcctggCgtgcgtccaggcccccaggc	19	16	0	0			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr2:107460204C>T	uc002tdq.2	-	2	349	c.230G>A	c.(229-231)CGC>CAC	p.R77H	ST6GAL2_uc002tdr.2_Missense_Mutation_p.R77H|ST6GAL2_uc002tds.3_Missense_Mutation_p.R77H	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	77	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CAGCGCCTGGCGTGCGTCCAG	0.677													T	107460204	T	T	107460204	3	4	128	1	0	0	0	0	1	0	0	0	15221	768	27	1	1466	1	ST6GAL2	2	107460204	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08	69958388	107460204	135739169	8	8781											
PPIG	9360	broad.mit.edu	37	chr2	170493100	170493100	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atcagaagaaattcagaaaaAgatgacaagtataaaaacaa	6	4	2	5			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr2:170493100A>C	uc002uez.2	+	14	1552	c.1332A>C	c.(1330-1332)AAA>AAC	p.K444N	PPIG_uc010fpx.2_Missense_Mutation_p.K429N|PPIG_uc010fpy.2_Missense_Mutation_p.K437N|PPIG_uc002ufb.2_Missense_Mutation_p.K444N|PPIG_uc002ufd.2_Missense_Mutation_p.K441N	NM_004792	NP_004783	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G	444					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)	ATTCAGAAAAAGATGACAAGT	0.313													C	170493100	C	C	170493100	3	2	128	1	0	0	0	0	1	0	0	0	12324	69	3	5	1378	5	PPIG	2	170493100	Missense_Mutation	SNP	A	TCGA-14-0786-01B-01D-1492-08	63032896	170493100	72706273	9	8782											
C3orf20	84077	broad.mit.edu	37	chr3	14802983	14802983	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttccttcctgtcaacagatgTttgccggggggaagctcatt	11	10	2	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr3:14802983T>A	uc003byy.2	+	15	2760	c.2356T>A	c.(2356-2358)TTT>ATT	p.F786I	C3orf20_uc003byz.2_Missense_Mutation_p.F664I|C3orf20_uc003bza.2_Missense_Mutation_p.F664I|C3orf20_uc003bzb.1_Missense_Mutation_p.F287I|C3orf20_uc011avj.1_Missense_Mutation_p.F113I	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	786	Helical; (Potential).					cytoplasm|integral to membrane				ovary(3)|skin(1)	4						TCAACAGATGTTTGCCGGGGG	0.483													A	14802983	A	A	14802983	3	1	128	1	0	0	0	0	1	0	0	0	2213	1725	60	5	2406	5	C3orf20	3	14802983	Missense_Mutation	SNP	T	TCGA-14-0786-01B-01D-1492-08		14802983	183219447	10	8783											
NR2C2	7182	broad.mit.edu	37	chr3	15079601	15079601	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcgaagctggatatagatggCtatgagtatgcataccttaa	11	6	0	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr3:15079601C>G	uc003bzj.3	+	12	1684	c.1467C>G	c.(1465-1467)GGC>GGG	p.G489G	NR2C2_uc003bzi.2_Silent_p.G508G	NM_003298	NP_003289	P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	489	Ligand-binding (By similarity).				cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						ATATAGATGGCTATGAGTATG	0.453													G	15079601	G	G	15079601	2	3	128	1	0	0	0	0	0	0	0	1	10623	784	28	5		5	NR2C2	3	15079601	Silent	SNP	C	TCGA-14-0786-01B-01D-1492-08	276618	15079601	182942829	11	8784											
HSPBAP1	79663	broad.mit.edu	37	chr3	122459942	122459942	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgattgcctcttctacccGggctaggtgatcctcttcct	10	13	3	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr3:122459942G>A	uc003efu.1	-	7	967	c.844C>T	c.(844-846)CGG>TGG	p.R282W	HSPBAP1_uc003eft.1_5'UTR	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	282	JmjC.					cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		TCTTCTACCCGGGCTAGGTGA	0.423													A	122459942	A	A	122459942	3	1	128	1	0	0	0	0	1	0	0	0	7425	1115	39	2	630	2	HSPBAP1	3	122459942	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08	107380341	122459942	75562488	12	8785											
SLIT2	9353	broad.mit.edu	37	chr4	20541195	20541195	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggcatttgatactctccattCtttatctactctgtaagtat	5	9	4	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr4:20541195C>A	uc003gpr.1	+	19	2168	c.1964C>A	c.(1963-1965)TCT>TAT	p.S655Y	SLIT2_uc003gps.1_Missense_Mutation_p.S647Y	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	655					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ACTCTCCATTCTTTATCTACT	0.299													A	20541195	A	A	20541195	3	1	128	1	0	0	0	0	1	0	0	0	14740	913	32	5	2038	5	SLIT2	4	20541195	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08		20541195	170613081	13	8786											
BANK1	55024	broad.mit.edu	37	chr4	102946614	102946614	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agacctcctctccccccgccGcgacctgtagctaatgcctt	7	19	1	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr4:102946614G>A	uc003hvy.3	+	9	1816	c.1542G>A	c.(1540-1542)CCG>CCA	p.P514P	BANK1_uc003hvx.3_Silent_p.P499P|BANK1_uc010ill.2_Silent_p.P381P|BANK1_uc003hvz.3_Silent_p.P484P	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	514					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TCCCCCCGCCGCGACCTGTAG	0.433													A	102946614	A	A	102946614	2	1	128	1	0	0	0	0	0	0	0	1	1309	1074	38	1		1	BANK1	4	102946614	Silent	SNP	G	TCGA-14-0786-01B-01D-1492-08	82405419	102946614	88207662	14	8787											
ALPK1	80216	broad.mit.edu	37	chr4	113353098	113353098	+	Frame_Shift_Del	DEL	C	-	-													cagaaagcactgaagatgcaCccttagactttcacagggtc							TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr4:113353098delC	uc003iap.3	+	11	2674	c.2395delC	c.(2395-2397)CCCfs	p.P799fs	ALPK1_uc003ian.3_Frame_Shift_Del_p.P799fs|ALPK1_uc011cfx.1_Frame_Shift_Del_p.P721fs|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Frame_Shift_Del_p.P627fs	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	799							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TGAAGATGCACCCTTAGACTT	0.488													-	113353098	-	-	113353098	7	5	128	1	0	1	0	1	0	0	0	0	544	507	18	0	2429	0	ALPK1	4	113353098	Frame_Shift_Del	DEL	C	TCGA-14-0786-01B-01D-1492-08	10406484	113353098	77801178	15	8788											
FHDC1	85462	broad.mit.edu	37	chr4	153897835	153897835	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtcggaaggactccagtcGgaccacgctggggagaatcc	14	13	0	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr4:153897835G>A	uc003inf.2	+	11	3467	c.3392G>A	c.(3391-3393)CGG>CAG	p.R1131Q		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1131					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					GACTCCAGTCGGACCACGCTG	0.637													A	153897835	A	A	153897835	3	1	128	1	0	0	0	0	1	0	0	0	5876	1116	39	2	3434	2	FHDC1	4	153897835	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08	40544737	153897835	37256441	16	8789											
POU4F3	5459	broad.mit.edu	37	chr5	145719603	145719603	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcatcaagctgggggtgaccCaggcggacgtgggcgcggct	19	11	1	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr5:145719603C>A	uc003loa.2	+	2	702	c.613C>A	c.(613-615)CAG>AAG	p.Q205K		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	205	POU-specific.				sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGGGTGACCCAGGCGGACGT	0.657													A	145719603	A	A	145719603	3	1	128	1	0	0	0	0	1	0	0	0	12280	595	21	5	619	5	POU4F3	5	145719603	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08		145719603	35195657	17	8790											
HIST1H2AA	221613	broad.mit.edu	37	chr6	25726720	25726720	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcgagacttagacttggcGcgtgcttttcctccctgctt	11	12	0	2	rs150563946	byFrequency	TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr6:25726720G>A	uc003nfc.2	-	1	71	c.36C>T	c.(34-36)CGC>CGT	p.R12R	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	12					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TAGACTTGGCGCGTGCTTTTC	0.532													A	25726720	A	A	25726720	2	1	128	1	0	0	0	0	0	0	0	1	7128	1074	38	1		1	HIST1H2AA	6	25726720	Silent	SNP	G	TCGA-14-0786-01B-01D-1492-08		25726720	145388347	18	8791											
BTN3A3	10384	broad.mit.edu	37	chr6	26452287	26452287	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggggatcttcctggactatgAgactggagagatctcgttct	13	8	3	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr6:26452287A>G	uc003nhz.2	+	11	1583	c.1403A>G	c.(1402-1404)GAG>GGG	p.E468G	BTN3A3_uc003nia.2_Missense_Mutation_p.E426G|BTN3A3_uc011dkn.1_Missense_Mutation_p.E419G	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	468	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0						CTGGACTATGAGACTGGAGAG	0.483													G	26452287	G	G	26452287	3	3	128	1	0	0	0	0	1	0	0	0	1564	304	11	4	1437	4	BTN3A3	6	26452287	Missense_Mutation	SNP	A	TCGA-14-0786-01B-01D-1492-08	725567	26452287	144662780	19	8792											
EEF1A1	1915	broad.mit.edu	37	chr6	74229196	74229196	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacgttcacgctcagctttcAgtttatccaagacccaggca	7	14	3	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr6:74229196A>C	uc003phi.2	-	2	225	c.188T>G	c.(187-189)CTG>CGG	p.L63R	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Missense_Mutation_p.L63R|EEF1A1_uc003phf.2_Missense_Mutation_p.L63R|EEF1A1_uc003phg.2_Missense_Mutation_p.L63R|EEF1A1_uc003phh.2_Intron|EEF1A1_uc003phj.2_Missense_Mutation_p.L63R|EEF1A1_uc003phk.2_Missense_Mutation_p.L63R|EEF1A1_uc003phl.2_Missense_Mutation_p.L63R|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	63						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						CTCAGCTTTCAGTTTATCCAA	0.428											OREG0003890	type=REGULATORY REGION|Gene=LOC477388|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	C	74229196	C	C	74229196	3	2	128	1	0	0	0	0	1	0	0	0	4923	188	7	5	1224	5	EEF1A1	6	74229196	Missense_Mutation	SNP	A	TCGA-14-0786-01B-01D-1492-08	47776909	74229196	96885871	20	8793											
IQCE	23288	broad.mit.edu	37	chr7	2611279	2611279	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagctgtggctgggaaccGcaaagccaggtatgtggttg	16	7	0	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr7:2611279G>A	uc003smo.3	+	4	434	c.250G>A	c.(250-252)GCA>ACA	p.A84T	IQCE_uc010ksm.1_Missense_Mutation_p.A84T|IQCE_uc003sml.1_Missense_Mutation_p.A84T|IQCE_uc011jvy.1_Missense_Mutation_p.A68T|IQCE_uc011jvz.1_Missense_Mutation_p.A19T|IQCE_uc003smk.3_Missense_Mutation_p.A68T|IQCE_uc003smn.3_Missense_Mutation_p.A19T	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	84											0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		GCTGGGAACCGCAAAGCCAGG	0.572													A	2611279	A	A	2611279	3	1	128	1	0	0	0	0	1	0	0	0	7806	1087	38	1	264	1	IQCE	7	2611279	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08		2611279	156527384	21	8794											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	128	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08	52610543	55221822	103916841	22	8795											
HBP1	26959	broad.mit.edu	37	chr7	106829793	106829793	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagaaagtgtatcatttggCgagtctgtactgaagttgac	12	5	2	3			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr7:106829793C>T	uc003vdy.2	+	7	1008	c.822C>T	c.(820-822)GGC>GGT	p.G274G	HBP1_uc011klv.1_Silent_p.G284G|HBP1_uc003vdz.2_Silent_p.G274G|HBP1_uc003vea.2_Silent_p.G274G|HBP1_uc003veb.1_Silent_p.G274G	NM_012257	NP_036389	O60381	HBP1_HUMAN	HMG-box transcription factor 1	274	AXH.				cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			skin(1)	1						TATCATTTGGCGAGTCTGTAC	0.368													T	106829793	T	T	106829793	2	4	128	1	0	0	0	0	0	0	0	1	6985	755	27	1		1	HBP1	7	106829793	Silent	SNP	C	TCGA-14-0786-01B-01D-1492-08	51607971	106829793	52308870	23	8796											
SLC30A8	169026	broad.mit.edu	37	chr8	118170045	118170045	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cagatccaggcgactgtgatGatcatcgtttccagctgcgc	11	12	1	3			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr8:118170045G>A	uc003yoh.2	+	4	764	c.534G>A	c.(532-534)ATG>ATA	p.M178I	SLC30A8_uc010mcz.2_Missense_Mutation_p.M129I|SLC30A8_uc011lia.1_Missense_Mutation_p.M129I|SLC30A8_uc003yog.2_Missense_Mutation_p.M129I	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	178	Helical; (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CGACTGTGATGATCATCGTTT	0.547													A	118170045	A	A	118170045	3	1	128	1	0	0	0	0	1	0	0	0	14561	1290	45	3	548	3	SLC30A8	8	118170045	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08		118170045	28193977	24	8797											
NFKBIL2	4796	broad.mit.edu	37	chr8	145662013	145662013	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccgcgtctccaggtccaggtCcctgcggtacagcttcaccc	10	18	2	0			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr8:145662013C>T	uc011llg.1	-	16	1957	c.1942G>A	c.(1942-1944)GAC>AAC	p.D648N	uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	648					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AGGTCCAGGTCCCTGCGGTAC	0.682													T	145662013	T	T	145662013	3	4	128	1	0	0	0	0	1	0	0	0	10382	855	30	3	2238	3	NFKBIL2	8	145662013	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08	27491968	145662013	702009	25	8798											
ABO	28	broad.mit.edu	37	chr9	136136731	136136731	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcactcaccagaacccccGttccaggcttcctggcatta	7	17	1	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr9:136136731G>A	uc004cda.1	-	3	170	c.145C>T	c.(145-147)CGG>TGG	p.R49W	ABO_uc010naf.1_Translation_Start_Site|ABO_uc011mcz.1_Translation_Start_Site|ABO_uc010nag.1_Intron	NM_020469	NP_065202	P16442	BGAT_HUMAN	ABO blood group (alpha	49	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		CAGAACCCCCGTTCCAGGCTT	0.607													A	136136731	A	A	136136731	3	1	128	1	0	0	0	0	1	0	0	0	97	1144	40	1	938	1	ABO	9	136136731	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08		136136731	5076700	26	8799											
ITIH5	80760	broad.mit.edu	37	chr10	7679260	7679260	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccagggatgcgatgcccgCgctctccaggatattcacgt	11	14	2	0			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr10:7679260C>T	uc001ijq.2	-	5	662	c.583G>A	c.(583-585)GCG>ACG	p.A195T	ITIH5_uc001ijr.1_Missense_Mutation_p.A195T	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	195					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						GCGATGCCCGCGCTCTCCAGG	0.662													T	7679260	T	T	7679260	3	4	128	1	0	0	0	0	1	0	0	0	7907	768	27	1	2422	1	ITIH5	10	7679260	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08		7679260	127855487	27	8800											
C10orf54	64115	broad.mit.edu	37	chr10	73521395	73521395	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atggcaccatggaccctgtgCtccgagtggtggtgcctgat	14	11	0	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr10:73521395C>G	uc001jsd.2	-	2	612	c.471G>C	c.(469-471)GAG>GAC	p.E157D	CDH23_uc001jrx.3_Intron|C10orf54_uc001jse.2_Missense_Mutation_p.E25D|C10orf54_uc009xqm.2_Intron|C10orf54_uc001jsf.1_Missense_Mutation_p.E157D	NM_022153	NP_071436	Q9H7M9	GI24_HUMAN	platelet receptor Gi24 precursor	157	Ig-like.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GGACCCTGTGCTCCGAGTGGT	0.617													G	73521395	G	G	73521395	3	3	128	1	0	0	0	0	1	0	0	0	1607	796	28	5	488	5	C10orf54	10	73521395	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08	65842135	73521395	62013352	28	8801											
KCNQ1	3784	broad.mit.edu	37	chr11	2592573	2592573	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacctcatcgtggtcgtggCctccatggtggtcctctgcg	13	13	2	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:2592573C>T	uc001lwn.2	+	4	731	c.623C>T	c.(622-624)GCC>GTC	p.A208V	KCNQ1_uc009ydp.1_Intron|KCNQ1_uc001lwo.2_Missense_Mutation_p.A81V	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	208	Helical; Name=Segment S3; (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	GTGGTCGTGGCCTCCATGGTG	0.652													T	2592573	T	T	2592573	3	4	128	1	0	0	0	0	1	0	0	0	8082	739	26	3	646	3	KCNQ1	11	2592573	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08		2592573	132413943	29	8802											
LDHAL6A	160287	broad.mit.edu	37	chr11	18487327	18487327	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atattacccagtacagtcctCactgcaaactgcttattgtt	5	11	1	0			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:18487327C>G	uc001mop.1	+	4	649	c.388C>G	c.(388-390)CAC>GAC	p.H130D	LDHAL6A_uc001moq.2_Missense_Mutation_p.H130D	NM_001144071	NP_001137543	Q6ZMR3	LDH6A_HUMAN	lactate dehydrogenase A-like 6A	130					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	GTACAGTCCTCACTGCAAACT	0.279													G	18487327	G	G	18487327	3	3	128	1	0	0	0	0	1	0	0	0	8699	826	29	5	398	5	LDHAL6A	11	18487327	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08	15894754	18487327	116519189	30	8803											
ANO5	203859	broad.mit.edu	37	chr11	22215065	22215065	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacccggatctcctggaagtGttggcggaggaaggtaggac	17	8	1	0			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:22215065G>A	uc001mqi.2	+	1	344	c.27G>A	c.(25-27)GTG>GTA	p.V9V	ANO5_uc001mqj.2_Silent_p.V9V	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	9	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TCCTGGAAGTGTTGGCGGAGG	0.667													A	22215065	A	A	22215065	2	1	128	1	0	0	0	0	0	0	0	1	700	1364	48	3		3	ANO5	11	22215065	Silent	SNP	G	TCGA-14-0786-01B-01D-1492-08	3727738	22215065	112791451	31	8804											
CKAP5	9793	broad.mit.edu	37	chr11	46801800	46801800	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggcttctcatcctcaaagaAcattcgcaaagagggaccaa	8	11	2	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:46801800A>G	uc001ndi.1	-	20	2487	c.2377T>C	c.(2377-2379)TTC>CTC	p.F793L	CKAP5_uc009ylg.1_Missense_Mutation_p.F679L|CKAP5_uc001ndj.1_Missense_Mutation_p.F793L	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	793					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TCCTCAAAGAACATTCGCAAA	0.428													G	46801800	G	G	46801800	3	3	128	1	0	0	0	0	1	0	0	0	3445	43	2	4	3821	4	CKAP5	11	46801800	Missense_Mutation	SNP	A	TCGA-14-0786-01B-01D-1492-08	24586735	46801800	88204716	32	8805											
OR4C3	256144	broad.mit.edu	37	chr11	48346804	48346804	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tattcttcttctatggctccTaaactcattgctgactcatt	4	11	5	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:48346804T>C	uc010rhv.1	+	1	312	c.312T>C	c.(310-312)CCT>CCC	p.P104P		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTATGGCTCCTAAACTCATTG	0.463													C	48346804	C	C	48346804	2	2	128	1	0	0	0	0	0	0	0	1	11050	1509	53	4		4	OR4C3	11	48346804	Silent	SNP	T	TCGA-14-0786-01B-01D-1492-08	1545004	48346804	86659712	33	8806											
OR10V1	390201	broad.mit.edu	37	chr11	59480721	59480721	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gatgaagctgatgatatacaGagcagtcttgtgaacgcgtg	13	6	1	5			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr11:59480721G>A	uc001nof.1	-	1	598	c.598C>T	c.(598-600)CTG>TTG	p.L200L		NM_001005324	NP_001005324	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATGATATACAGAGCAGTCTTG	0.498													A	59480721	A	A	59480721	2	1	128	1	0	0	0	0	0	0	0	1	10920	933	33	3		3	OR10V1	11	59480721	Silent	SNP	G	TCGA-14-0786-01B-01D-1492-08	11133917	59480721	75525795	34	8807											
USP15	9958	broad.mit.edu	37	chr12	62777954	62777954	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaatcaactttagtttgTcctgagtgtgctaagatttc	7	7	2	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr12:62777954T>C	uc001src.1	+	11	1353	c.1344T>C	c.(1342-1344)TGT>TGC	p.C448C	USP15_uc001srb.1_Silent_p.C419C	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	448					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		CTTTAGTTTGTCCTGAGTGTG	0.358													C	62777954	C	C	62777954	2	2	128	1	0	0	0	0	0	0	0	1	17043	1673	58	4		4	USP15	12	62777954	Silent	SNP	T	TCGA-14-0786-01B-01D-1492-08		62777954	71073941	35	8808											
ADAM21	8747	broad.mit.edu	37	chr14	70926319	70926319	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgactttcctgtttactgtCgggcttcttatgtatctacg	8	9	2	1	rs142273524	byFrequency	TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr14:70926319C>T	uc001xmd.2	+	1	2103	c.2103C>T	c.(2101-2103)GTC>GTT	p.V701V		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	701	Helical; (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TGTTTACTGTCGGGCTTCTTA	0.413													T	70926319	T	T	70926319	2	4	128	1	0	0	0	0	0	0	0	1	243	871	31	2		2	ADAM21	14	70926319	Silent	SNP	C	TCGA-14-0786-01B-01D-1492-08		70926319	36423221	36	8809											
ZDHHC1	29800	broad.mit.edu	37	chr16	67429021	67429021	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgccaaaagaagcagaggcgAgcgccagggtagaggcttct	15	10	1	3			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr16:67429021A>T	uc010vjm.1	-	10	1418	c.1114T>A	c.(1114-1116)TCG>ACG	p.S372T	TPPP3_uc002eta.2_5'Flank|TPPP3_uc002etb.2_5'Flank	NM_013304	NP_037436	Q8WTX9	ZDHC1_HUMAN	zinc finger, DHHC-type containing 1	372						integral to membrane	DNA binding|zinc ion binding				0		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		AGCAGAGGCGAGCGCCAGGGT	0.622													T	67429021	T	T	67429021	3	4	128	1	0	0	0	0	1	0	0	0	17597	304	11	5	351	5	ZDHHC1	16	67429021	Missense_Mutation	SNP	A	TCGA-14-0786-01B-01D-1492-08		67429021	22925732	37	8810											
KRTAP3-3	85293	broad.mit.edu	37	chr17	39150169	39150169	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caggaagcaggtgggcacgcAgggctgaggaatgtggcagg	20	7	0	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr17:39150169A>G	uc002hvr.1	-	1	217	c.181T>C	c.(181-183)TGC>CGC	p.C61R		NM_033185	NP_149441	Q9BYR6	KRA33_HUMAN	keratin associated protein 3-3	61						keratin filament	structural molecule activity				0		Breast(137;0.00043)				GTGGGCACGCAGGGCTGAGGA	0.627													G	39150169	G	G	39150169	3	3	128	1	0	0	0	0	1	0	0	0	8547	188	7	4	119	4	KRTAP3-3	17	39150169	Missense_Mutation	SNP	A	TCGA-14-0786-01B-01D-1492-08		39150169	42045041	38	8811											
ARHGAP28	79822	broad.mit.edu	37	chr18	6859874	6859874	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggataaagaagggagttttgCggttcccaggagtgactctg	15	6	1	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr18:6859874C>T	uc010wzi.1	+	4	411	c.173C>T	c.(172-174)GCG>GTG	p.A58V	ARHGAP28_uc002knc.2_Missense_Mutation_p.A183V|ARHGAP28_uc002knd.2_Missense_Mutation_p.A76V|ARHGAP28_uc002kne.2_Missense_Mutation_p.A76V|ARHGAP28_uc002knf.2_Missense_Mutation_p.A67V			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	58					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				GGGAGTTTTGCGGTTCCCAGG	0.433													T	6859874	T	T	6859874	3	4	128	1	0	0	0	0	1	0	0	0	877	768	27	1	237	1	ARHGAP28	18	6859874	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08		6859874	71217374	39	8812											
ABCA7	10347	broad.mit.edu	37	chr19	1042173	1042173	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgagggctgcacgcagcaCgggtgaggaggccggggggc	22	10	0	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr19:1042173C>T	uc002lqw.3	+	5	644	c.413C>T	c.(412-414)ACG>ATG	p.T138M	ABCA7_uc010dsb.1_5'Flank|ABCA7_uc010dsa.2_Missense_Mutation_p.T138M	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	138	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACGCAGCACGGGTGAGGAG	0.692													T	1042173	T	T	1042173	3	4	128	1	0	0	0	0	1	0	0	0	37	536	19	1	427	1	ABCA7	19	1042173	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08		1042173	58086810	40	8813											
PPM1N	147699	broad.mit.edu	37	chr19	46003206	46003206	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctttttctccaccggcttcaGggcagcctggacaacatgac	9	14	2	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr19:46003206G>C	uc002pce.2	+	2	940	c.940_splice	c.e2-1	p.G314_splice	RTN2_uc002pcb.2_5'Flank|RTN2_uc002pcc.2_5'Flank|RTN2_uc002pcd.2_5'Flank|PPM1N_uc002pcf.2_Splice_Site	NM_001080401	NP_001073870	Q8N819	PPM1N_HUMAN	protein phosphatase 1B-like								magnesium ion binding|manganese ion binding|phosphoprotein phosphatase activity				0						ACCGGCTTCAGGGCAGCCTGG	0.607													C	46003206	C	C	46003206	5	2	128	1	0	0	0	0	0	0	1	0	12346	1014	35	5	945	5	PPM1N	19	46003206	Splice_Site	SNP	G	TCGA-14-0786-01B-01D-1492-08	44961033	46003206	13125777	41	8814											
ZSCAN5B	342933	broad.mit.edu	37	chr19	56701423	56701423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtaaggtggactcgtgggCgaaccgcttttggcagacgt	15	9	0	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr19:56701423C>T	uc010ygh.1	-	4	1261	c.1261G>A	c.(1261-1263)GCC>ACC	p.A421T		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	421	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GACTCGTGGGCGAACCGCTTT	0.567													T	56701423	T	T	56701423	3	4	128	1	0	0	0	0	1	0	0	0	18236	768	27	1	230	1	ZSCAN5B	19	56701423	Missense_Mutation	SNP	C	TCGA-14-0786-01B-01D-1492-08	10698217	56701423	2427560	42	8815											
KRTAP19-2	337969	broad.mit.edu	37	chr21	31859635	31859635	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccatagcccagtctgcagaaGctgccacatccacagccgta	8	16	1	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr21:31859635G>T	uc011acy.1	-	1	33	c.33C>A	c.(31-33)AGC>AGA	p.S11R		NM_181608	NP_853639	Q3LHN2	KR192_HUMAN	keratin associated protein 19-2	11						intermediate filament					0						GTCTGCAGAAGCTGCCACATC	0.572													T	31859635	T	T	31859635	3	4	128	1	0	0	0	0	1	0	0	0	8529	962	34	5	127	5	KRTAP19-2	21	31859635	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08		31859635	16270260	43	8816											
TMPRSS3	64699	broad.mit.edu	37	chr21	43803237	43803237	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactgaaggctggcctgccaGggccactgcgagagcaagga	15	11	0	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr21:43803237G>A	uc002zbb.2	-	8	888	c.687C>T	c.(685-687)CCC>CCT	p.P229P	TMPRSS3_uc002zay.2_5'UTR|TMPRSS3_uc002zaz.2_Silent_p.P102P|TMPRSS3_uc002zba.2_Silent_p.P102P|TMPRSS3_uc002zbc.2_Silent_p.P229P|TMPRSS3_uc002zbd.2_Silent_p.P229P	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	229	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						TGGCCTGCCAGGGCCACTGCG	0.587													A	43803237	A	A	43803237	2	1	128	1	0	0	0	0	0	0	0	1	16245	987	35	3		3	TMPRSS3	21	43803237	Silent	SNP	G	TCGA-14-0786-01B-01D-1492-08	11943602	43803237	4326658	44	8817											
C22orf24	25775	broad.mit.edu	37	chr22	32334001	32334001	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgctccaggtcttgacatggTccaaagacttgtcttttgat	9	10	2	3			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chr22:32334001T>C	uc003aly.2	-	2	219	c.52A>G	c.(52-54)ACC>GCC	p.T18A	C22orf24_uc003alx.2_RNA	NM_015372	NP_056187	Q9Y442	CV024_HUMAN	hypothetical protein LOC25775	18						integral to membrane				central_nervous_system(1)	1						CTTGACATGGTCCAAAGACTT	0.413													C	32334001	C	C	32334001	3	2	128	1	0	0	0	0	1	0	0	0	2138	1667	58	4	438	4	C22orf24	22	32334001	Missense_Mutation	SNP	T	TCGA-14-0786-01B-01D-1492-08		32334001	18970565	45	8818											
NLGN4X	57502	broad.mit.edu	37	chrX	5811156	5811156	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggatgtgagcgatatcatttGtggtgtttctctggggactg	15	5	2	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:5811156G>T	uc010ndh.2	-	6	2654	c.2153C>A	c.(2152-2154)ACA>AAA	p.T718K	NLGN4X_uc004crp.2_Missense_Mutation_p.T738K|NLGN4X_uc004crq.2_Missense_Mutation_p.T718K|NLGN4X_uc010ndi.2_Missense_Mutation_p.T755K|NLGN4X_uc004crr.2_Missense_Mutation_p.T718K|NLGN4X_uc010ndj.2_Missense_Mutation_p.T718K	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	718	Cytoplasmic (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GATATCATTTGTGGTGTTTCT	0.522													T	5811156	T	T	5811156	3	4	128	1	0	0	0	0	1	0	0	0	10464	1377	48	5	301	5	NLGN4X	23	5811156	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08		5811156	149459404	46	8819											
SSX3	10214	broad.mit.edu	37	chrX	48209558	48209558	+	Splice_Site	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gctggcttcttgggcatgatCtttataatgtgaaggtcata	11	6	3	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:48209558C>T	uc004djd.1	-	6	425	c.331_splice	c.e6-1	p.I111_splice	SSX3_uc004dje.2_Splice_Site_p.I111_splice	NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						TGGGCATGATCTTTATAATGT	0.323													T	48209558	T	T	48209558	5	4	128	1	0	0	0	0	0	0	1	0	15204	927	32	3	295	3	SSX3	23	48209558	Splice_Site	SNP	C	TCGA-14-0786-01B-01D-1492-08	42398402	48209558	107061002	47	8820											
KCND1	3750	broad.mit.edu	37	chrX	48822565	48822565	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcaaggcggatggcgcggcGcttggccctgcgagggcagc	20	12	0	0			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:48822565G>A	uc004dlx.1	-	5	3188	c.1615C>T	c.(1615-1617)CGC>TGC	p.R539C	KCND1_uc004dlw.1_Missense_Mutation_p.R162C	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	539	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						ATGGCGCGGCGCTTGGCCCTG	0.682													A	48822565	A	A	48822565	3	1	128	1	0	0	0	0	1	0	0	0	8018	1087	38	1	336	1	KCND1	23	48822565	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08	613007	48822565	106447995	48	8821											
KIAA1210	57481	broad.mit.edu	37	chrX	118222577	118222577	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagggtgtctgagaggcagGtcttcctctgagctgctgca	15	10	3	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:118222577G>A	uc004era.3	-	11	2616	c.2616C>T	c.(2614-2616)GAC>GAT	p.D872D		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	872										ovary(4)|skin(1)	5						TGAGAGGCAGGTCTTCCTCTG	0.448													A	118222577	A	A	118222577	2	1	128	1	0	0	0	0	0	0	0	1	8214	1252	44	3		3	KIAA1210	23	118222577	Silent	SNP	G	TCGA-14-0786-01B-01D-1492-08	69400012	118222577	37047983	49	8822											
MAGEC2	51438	broad.mit.edu	37	chrX	141291256	141291256	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caggaaagtaatctttgtacTtgatgacaatcatcagcatc	7	8	3	2			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:141291256T>G	uc004fbu.1	-	3	866	c.518A>C	c.(517-519)AAG>ACG	p.K173T		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	173	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ATCTTTGTACTTGATGACAAT	0.478										HNSCC(46;0.14)			G	141291256	G	G	141291256	3	3	128	1	0	0	0	0	1	0	0	0	9181	1609	56	5	607	5	MAGEC2	23	141291256	Missense_Mutation	SNP	T	TCGA-14-0786-01B-01D-1492-08	23068679	141291256	13979304	50	8823											
MAGEA6	4105	broad.mit.edu	37	chrX	151870086	151870086	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaaactacctggagtaccGgcaggtccccggcagtgatc	13	12	0	1			TCGA-14-0786-01B-01D-1492-08	TCGA-14-0786-10A-01D-1492-08									Somatic	Phase_I	Capture				Illumina GAIIx	75fa4de1-29fd-4b54-b63a-add459f1d69c	c5e922d3-306a-4b3a-b05f-a75f05af3200	g.chrX:151870086G>A	uc004ffq.1	+	3	970	c.776G>A	c.(775-777)CGG>CAG	p.R259Q	MAGEA6_uc004ffr.1_Missense_Mutation_p.R259Q|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	259	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CTGGAGTACCGGCAGGTCCCC	0.522													A	151870086	A	A	151870086	3	1	128	1	0	0	0	0	1	0	0	0	9170	1116	39	2	778	2	MAGEA6	23	151870086	Missense_Mutation	SNP	G	TCGA-14-0786-01B-01D-1492-08	10578830	151870086	3400474	51	8824											
MRTO4	51154	broad.mit.edu	37	chr1	19584431	19584431	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggagcagttcccccactccaTggagccacagctcaggcagc	11	16	1	0			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr1:19584431T>G	uc001bbs.2	+	6	701	c.446T>G	c.(445-447)ATG>AGG	p.M149R		NM_016183	NP_057267	Q9UKD2	MRT4_HUMAN	mRNA turnover 4 homolog	149					ribosome biogenesis	nuclear membrane|nucleolus					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.87e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00301)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCACTCCATGGAGCCACAG	0.597													G	19584431	G	G	19584431	3	3	129	1	0	0	0	0	1	0	0	0	9852	1464	51	5	468	5	MRTO4	1	19584431	Missense_Mutation	SNP	T	TCGA-14-0787-01A-01W-0424-08		19584431	229666190	1	8825											
SF3A3	10946	broad.mit.edu	37	chr1	38435290	38435290	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tttggggttgtaaatgatctCgttctcttcatcttcactct	7	9	6	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr1:38435290C>A	uc001cci.2	-	13	1247	c.1123G>T	c.(1123-1125)GAG>TAG	p.E375*	SF3A3_uc010oik.1_Nonsense_Mutation_p.E322*	NM_006802	NP_006793	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3	375					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TAAATGATCTCGTTCTCTTCA	0.468													A	38435290	A	A	38435290	4	1	129	1	0	0	0	0	0	1	0	0	14148	893	31	5	402	5	SF3A3	1	38435290	Nonsense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08	18850859	38435290	210815331	2	8826											
HMCN1	83872	broad.mit.edu	37	chr1	186099788	186099788	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaaattagccacagaatcCggcaactgggcaatggctcc	10	11	0	2			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr1:186099788C>T	uc001grq.1	+	85	13418	c.13189C>T	c.(13189-13191)CGG>TGG	p.R4397W	HMCN1_uc001grs.1_5'UTR	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4397	Ig-like C2-type 43.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CCACAGAATCCGGCAACTGGG	0.507													T	186099788	T	T	186099788	3	4	129	1	0	0	0	0	1	0	0	0	7220	643	23	2	13527	2	HMCN1	1	186099788	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08	147664498	186099788	63150833	3	8827											
DENND1B	163486	broad.mit.edu	37	chr1	197522236	197522236	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tagttttgccagtcgaccatCgataaactagaattaaaaag	7	7	0	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr1:197522236C>T	uc001guf.3	-	16	1494	c.1156G>A	c.(1156-1158)GAT>AAT	p.D386N	DENND1B_uc010ppe.1_Missense_Mutation_p.D366N|DENND1B_uc010ppf.1_Intron|DENND1B_uc001gue.3_Missense_Mutation_p.D356N	NM_144977	NP_659414	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 2	386	dDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						AGTCGACCATCGATAAACTAG	0.303													T	197522236	T	T	197522236	3	4	129	1	0	0	0	0	1	0	0	0	4427	884	31	2	1244	2	DENND1B	1	197522236	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08	11422448	197522236	51728385	4	8828											
RYR2	6262	broad.mit.edu	37	chr1	237791221	237791221	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccatcggcagtatgacgGcattgggggtcttgttcggg	16	9	1	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr1:237791221G>A	uc001hyl.1	+	41	6401	c.6281G>A	c.(6280-6282)GGC>GAC	p.G2094D		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2094	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGTATGACGGCATTGGGGGT	0.557													A	237791221	A	A	237791221	3	1	129	1	0	0	0	0	1	0	0	0	13769	1203	42	3	6443	3	RYR2	1	237791221	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08	40268985	237791221	11459400	5	8829											
VPS54	51542	broad.mit.edu	37	chr2	64147109	64147109	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacatctgcttgcttccagCgctcattgtctaagaggagg	11	10	3	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr2:64147109C>T	uc002scq.2	-	15	2235	c.2072G>A	c.(2071-2073)CGC>CAC	p.R691H	VPS54_uc002scp.2_Missense_Mutation_p.R679H|VPS54_uc002scn.2_5'UTR|VPS54_uc002sco.2_Missense_Mutation_p.R176H|VPS54_uc010fct.2_Missense_Mutation_p.R538H	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	691					protein transport|retrograde transport, endosome to Golgi						0						TTGCTTCCAGCGCTCATTGTC	0.393													T	64147109	T	T	64147109	3	4	129	1	0	0	0	0	1	0	0	0	17213	768	27	1	897	1	VPS54	2	64147109	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08		64147109	179052264	6	8830											
RGPD4	285190	broad.mit.edu	37	chr2	108455386	108455386	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggtggaaagagcagcaaaacTtttcccaggaagtcctgcaa	11	9	0	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr2:108455386T>A	uc010ywk.1	+	4	453	c.371T>A	c.(370-372)CTT>CAT	p.L124H	RGPD4_uc002tdu.2_5'UTR	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	124					intracellular transport		binding			skin(2)	2						GCAGCAAAACTTTTCCCAGGA	0.333													A	108455386	A	A	108455386	3	1	129	1	0	0	0	0	1	0	0	0	13288	1609	56	5	385	5	RGPD4	2	108455386	Missense_Mutation	SNP	T	TCGA-14-0787-01A-01W-0424-08	44308277	108455386	134743987	7	8831											
GTDC1	79712	broad.mit.edu	37	chr2	144765034	144765034	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aaggaagggccatggacagaAccgcaccgccatttccttta	10	12	0	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr2:144765034A>T	uc002tvp.2	-	7	869	c.590T>A	c.(589-591)GTT>GAT	p.V197D	GTDC1_uc002tvo.2_Missense_Mutation_p.V197D|GTDC1_uc002tvq.2_Intron|GTDC1_uc002tvr.2_Missense_Mutation_p.V197D|GTDC1_uc010fnn.2_Missense_Mutation_p.V197D|GTDC1_uc002tvs.2_Missense_Mutation_p.V165D|GTDC1_uc010fno.2_Missense_Mutation_p.V68D|GTDC1_uc002tvt.1_Missense_Mutation_p.V197D	NM_001006636	NP_001006637	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	197					biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)		CATGGACAGAACCGCACCGCC	0.403													T	144765034	T	T	144765034	3	4	129	1	0	0	0	0	1	0	0	0	6851	43	2	5	810	5	GTDC1	2	144765034	Missense_Mutation	SNP	A	TCGA-14-0787-01A-01W-0424-08	36309648	144765034	98434339	8	8832											
ALS2CR11	151254	broad.mit.edu	37	chr2	202401017	202401017	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaaagttggtatagtcagGcctttctcagaatcattatc	7	8	4	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr2:202401017G>A	uc002uye.2	-	13	1281	c.1233C>T	c.(1231-1233)GGC>GGT	p.G411G	ALS2CR11_uc002uyf.2_Silent_p.G411G|ALS2CR11_uc010fti.2_Intron	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	411										large_intestine(1)|ovary(1)|skin(1)	3						GTATAGTCAGGCCTTTCTCAG	0.338													A	202401017	A	A	202401017	2	1	129	1	0	0	0	0	0	0	0	1	552	1190	42	3		3	ALS2CR11	2	202401017	Silent	SNP	G	TCGA-14-0787-01A-01W-0424-08	57635983	202401017	40798356	9	8833											
ALS2CR11	151254	broad.mit.edu	37	chr2	202483675	202483675	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttgttcttaggcagggccGtcgtgccctggttcagggcg	15	11	3	0			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr2:202483675G>A	uc002uye.2	-	1	227	c.179C>T	c.(178-180)ACG>ATG	p.T60M	ALS2CR11_uc002uyf.2_Missense_Mutation_p.T60M|ALS2CR11_uc010fti.2_Missense_Mutation_p.T60M	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	60										large_intestine(1)|ovary(1)|skin(1)	3						AGGCAGGGCCGTCGTGCCCTG	0.642													A	202483675	A	A	202483675	3	1	129	1	0	0	0	0	1	0	0	0	552	1145	40	1	5494	1	ALS2CR11	2	202483675	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08	82658	202483675	40715698	10	8834											
FAM124B	79843	broad.mit.edu	37	chr2	225266256	225266256	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaatagcctatcctctcccGggctttcgtgcaggaagagc	11	12	1	1	rs149161165	by1000genomes	TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr2:225266256G>A	uc002vnx.2	-	1	456	c.230C>T	c.(229-231)CCG>CTG	p.P77L	FAM124B_uc002vnw.2_Missense_Mutation_p.P77L	NM_001122779	NP_001116251	Q9H5Z6	F124B_HUMAN	hypothetical protein LOC79843 isoform a	77							protein binding			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		ATCCTCTCCCGGGCTTTCGTG	0.572													A	225266256	A	A	225266256	3	1	129	1	0	0	0	0	1	0	0	0	5426	1116	39	2	1236	2	FAM124B	2	225266256	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08	22782581	225266256	17933117	11	8835											
ANO7	50636	broad.mit.edu	37	chr2	242142864	242142864	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtaccagcccctggaccaCgtgcgcaggtacttcgggga	13	13	0	0			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr2:242142864C>T	uc002wax.2	+	9	1105	c.1002C>T	c.(1000-1002)CAC>CAT	p.H334H		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	334	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CCCTGGACCACGTGCGCAGGT	0.692													T	242142864	T	T	242142864	2	4	129	1	0	0	0	0	0	0	0	1	702	535	19	1		1	ANO7	2	242142864	Silent	SNP	C	TCGA-14-0787-01A-01W-0424-08	16876608	242142864	1056509	12	8836											
FRYL	285527	broad.mit.edu	37	chr4	48569356	48569356	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctttttcattttctgcttcCaggagttgtctagttaaatc	6	8	4	0			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr4:48569356C>T	uc003gyh.1	-	28	3683	c.3078G>A	c.(3076-3078)CTG>CTA	p.L1026L	FRYL_uc003gyk.2_Silent_p.L1026L|FRYL_uc003gyi.1_5'Flank	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1026					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TTTCTGCTTCCAGGAGTTGTC	0.343													T	48569356	T	T	48569356	2	4	129	1	0	0	0	0	0	0	0	1	6064	581	21	3		3	FRYL	4	48569356	Silent	SNP	C	TCGA-14-0787-01A-01W-0424-08		48569356	142584920	13	8837											
USO1	8615	broad.mit.edu	37	chr4	76722293	76722293	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaagaagaagaggtgaaAaaaacattagaacagcatga	9	3	0	6			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr4:76722293A>G	uc003hiu.2	+	16	2101	c.1926A>G	c.(1924-1926)AAA>AAG	p.K642K	USO1_uc003hiv.2_Silent_p.K484K|USO1_uc003hiw.2_Silent_p.K477K	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	642	Potential.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AAGAGGTGAAAAAAACATTAG	0.294													G	76722293	G	G	76722293	2	3	129	1	0	0	0	0	0	0	0	1	17036	11	1	4		4	USO1	4	76722293	Silent	SNP	A	TCGA-14-0787-01A-01W-0424-08	28152937	76722293	114431983	14	8838											
VCAN	1462	broad.mit.edu	37	chr5	82849273	82849273	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacatgggatgcagctgaacGggaatgccgtctgcagggtg	16	9	1	1	rs145625752		TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr5:82849273G>A	uc003kii.3	+	11	9940	c.9584G>A	c.(9583-9585)CGG>CAG	p.R3195Q	VCAN_uc003kij.3_Missense_Mutation_p.R2208Q|VCAN_uc010jau.2_Missense_Mutation_p.R1441Q|VCAN_uc003kik.3_Missense_Mutation_p.R454Q|VCAN_uc003kil.3_Missense_Mutation_p.R1859Q	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	3195	C-type lectin.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GCAGCTGAACGGGAATGCCGT	0.473													A	82849273	A	A	82849273	3	1	129	1	0	0	0	0	1	0	0	0	17135	1116	39	2	9622	2	VCAN	5	82849273	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08		82849273	98065987	15	8839											
FAT2	2196	broad.mit.edu	37	chr5	150922879	150922879	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggccaacacctggataacCggagagtctttactgacatt	9	10	1	2			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr5:150922879C>T	uc003lue.3	-	9	7822	c.7809G>A	c.(7807-7809)CCG>CCA	p.P2603P	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2603	Cadherin 23.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTGGATAACCGGAGAGTCTT	0.443													T	150922879	T	T	150922879	2	4	129	1	0	0	0	0	0	0	0	1	5690	639	23	2		2	FAT2	5	150922879	Silent	SNP	C	TCGA-14-0787-01A-01W-0424-08	68073606	150922879	29992381	16	8840											
HK3	3101	broad.mit.edu	37	chr5	176314737	176314737	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcactgtcccctgcaggaCgctgcagaacctacagatac	8	15	1	2			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr5:176314737C>T	uc003mfa.2	-	11	1407	c.1315G>A	c.(1315-1317)GTC>ATC	p.V439I	HK3_uc003mez.2_5'UTR	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	439	Regulatory.			V -> I (in Ref. 4; AAC50422).	glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCTGCAGGACGCTGCAGAAC	0.622													T	176314737	T	T	176314737	3	4	129	1	0	0	0	0	1	0	0	0	7192	536	19	1	1492	1	HK3	5	176314737	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08	25391858	176314737	4600523	17	8841											
CARD11	84433	broad.mit.edu	37	chr7	2963984	2963984	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggagggtccgaaggagtagCgttcgtgactgtcatctgca	15	8	2	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr7:2963984C>T	uc003smv.2	-	15	2227	c.1823G>A	c.(1822-1824)CGC>CAC	p.R608H		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	608					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GAAGGAGTAGCGTTCGTGACT	0.642			Mis		DLBCL								T	2963984	T	T	2963984	3	4	129	1	0	0	0	0	1	0	0	0	2645	768	27	1	1685	1	CARD11	7	2963984	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08		2963984	156174679	18	8842											
PON3	5446	broad.mit.edu	37	chr7	95019499	95019499	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccagcccactaggaagtatAtcaatatcttcagagccact	7	12	3	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr7:95019499A>G	uc003unt.2	-	3	193	c.168T>C	c.(166-168)GAT>GAC	p.D56D	PON1_uc011kih.1_Intron|PON3_uc011kii.1_Silent_p.D56D	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	56					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TAGGAAGTATATCAATATCTT	0.378													G	95019499	G	G	95019499	2	3	129	1	0	0	0	0	0	0	0	1	12250	446	16	4		4	PON3	7	95019499	Silent	SNP	A	TCGA-14-0787-01A-01W-0424-08	92055515	95019499	64119164	19	8843											
PLXNA4	91584	broad.mit.edu	37	chr7	131872361	131872361	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggcttcagatctgagagagtCagtgtctgtgtagaaaggat	14	5	4	4			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr7:131872361C>T	uc003vra.3	-	15	3091	c.2862G>A	c.(2860-2862)CTG>CTA	p.L954L		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	954	IPT/TIG 2.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CTGAGAGAGTCAGTGTCTGTG	0.617													T	131872361	T	T	131872361	2	4	129	1	0	0	0	0	0	0	0	1	12122	813	29	3		3	PLXNA4	7	131872361	Silent	SNP	C	TCGA-14-0787-01A-01W-0424-08	36852862	131872361	27266302	20	8844											
SSPO	23145	broad.mit.edu	37	chr7	149493732	149493732	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggttggactccgctgtgccaGtggtgagtgtgtcctgagag	17	8	0	2			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr7:149493732G>T	uc010lpk.2	+	46	6728	c.6728G>T	c.(6727-6729)AGT>ATT	p.S2243I		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2243	LDL-receptor class A 8.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGCTGTGCCAGTGGTGAGTGT	0.652													T	149493732	T	T	149493732	3	4	129	1	0	0	0	0	1	0	0	0	15188	1029	36	5	6902	5	SSPO	7	149493732	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08	17621371	149493732	9644931	21	8845											
WDR67	93594	broad.mit.edu	37	chr8	124109565	124109565	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gaggcaagtcaaatcatcttCatttgtggtgcttggaagct	11	7	4	0			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr8:124109565C>T	uc003ypp.1	+	6	805	c.715C>T	c.(715-717)CAT>TAT	p.H239Y	WDR67_uc011lig.1_Missense_Mutation_p.H239Y|WDR67_uc011lih.1_Missense_Mutation_p.H129Y|WDR67_uc003ypq.1_RNA|WDR67_uc003ypo.1_Missense_Mutation_p.H239Y|WDR67_uc003ypr.2_RNA	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	239	WD 4.					centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			AAATCATCTTCATTTGTGGTG	0.398													T	124109565	T	T	124109565	3	4	129	1	0	0	0	0	1	0	0	0	17315	826	29	3	737	3	WDR67	8	124109565	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08		124109565	22254457	22	8846											
INPP5E	56623	broad.mit.edu	37	chr9	139327520	139327520	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgtgtggtcaccgtggagcaCtccacctctgtgggaggggc	16	12	2	0			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr9:139327520C>G	uc004cho.2	-	5	1552	c.1167G>C	c.(1165-1167)GAG>GAC	p.E389D	INPP5E_uc010nbm.2_Missense_Mutation_p.E389D	NM_019892	NP_063945	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase E	389						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			skin(1)	1		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		CCGTGGAGCACTCCACCTCTG	0.627													G	139327520	G	G	139327520	3	3	129	1	0	0	0	0	1	0	0	0	7757	564	20	5	791	5	INPP5E	9	139327520	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08		139327520	1885911	23	8847											
KCNK18	338567	broad.mit.edu	37	chr10	118957199	118957199	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gttcttggaggagctctgcaGaatcttgaactgcagtgaaa	12	7	3	3			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr10:118957199G>T	uc010qsr.1	+	1	200	c.200G>T	c.(199-201)AGA>ATA	p.R67I		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	67						integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		GAGCTCTGCAGAATCTTGAAC	0.582													T	118957199	T	T	118957199	3	4	129	1	0	0	0	0	1	0	0	0	8065	942	33	5	202	5	KCNK18	10	118957199	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08		118957199	16577548	24	8848											
TIAL1	7073	broad.mit.edu	37	chr10	121341480	121341480	+	Frame_Shift_Del	DEL	T	-	-													tgatttgatatcttctgttgTaatttctggactcaaatccc							TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr10:121341480delT	uc001lei.1	-	5	889	c.325delA	c.(325-327)ACAfs	p.T109fs	TIAL1_uc001leh.1_Frame_Shift_Del_p.T87fs|TIAL1_uc001lej.1_Frame_Shift_Del_p.T126fs|TIAL1_uc001lek.1_5'UTR|TIAL1_uc009xzi.1_5'UTR|TIAL1_uc010qtb.1_5'UTR	NM_003252	NP_003243	Q01085	TIAR_HUMAN	TIA-1 related protein isoform 1	109	RRM 2.				apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		TCTTCTGTTGTAATTTCTGGA	0.348													-	121341480	-	-	121341480	7	5	129	1	0	1	0	1	0	0	0	0	15886	1638	57	0	834	0	TIAL1	10	121341480	Frame_Shift_Del	DEL	T	TCGA-14-0787-01A-01W-0424-08	2384281	121341480	14193267	25	8849											
DCHS1	8642	broad.mit.edu	37	chr11	6647232	6647232	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtctacgtggaacaatccaCgtgccggctgggatgcagcc	14	12	1	0	rs149822394		TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr11:6647232C>T	uc001mem.1	-	17	7060	c.6650G>A	c.(6649-6651)CGT>CAT	p.R2217H		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2217	Extracellular (Potential).|Cadherin 21.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAACAATCCACGTGCCGGCTG	0.602													T	6647232	T	T	6647232	3	4	129	1	0	0	0	0	1	0	0	0	4287	536	19	1	3266	1	DCHS1	11	6647232	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08		6647232	128359284	26	8850											
OR8J3	81168	broad.mit.edu	37	chr11	55904448	55904448	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcattgtcccatagaaaacCgtgactgctatcatatgcga	8	10	1	2			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr11:55904448C>T	uc010riz.1	-	1	747	c.747G>A	c.(745-747)ACG>ACA	p.T249T		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					CATAGAAAACCGTGACTGCTA	0.398													T	55904448	T	T	55904448	2	4	129	1	0	0	0	0	0	0	0	1	11242	639	23	2		2	OR8J3	11	55904448	Silent	SNP	C	TCGA-14-0787-01A-01W-0424-08	49257216	55904448	79102068	27	8851											
GIF	2694	broad.mit.edu	37	chr11	59610023	59610023	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgccaagatcgctagactgGgcccatagaaggctgatgct	13	10	0	4			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr11:59610023G>T	uc001noi.2	-	4	452	c.404C>A	c.(403-405)CCC>CAC	p.P135H	GIF_uc010rkz.1_3'UTR	NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	135					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						CGCTAGACTGGGCCCATAGAA	0.562													T	59610023	T	T	59610023	3	4	129	1	0	0	0	0	1	0	0	0	6376	1232	43	5	873	5	GIF	11	59610023	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08	3705575	59610023	75396493	28	8852											
SCNN1A	6337	broad.mit.edu	37	chr12	6464465	6464465	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgctgatggaggtctccacGccaggccgcaagttaaagcc	12	12	1	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr12:6464465G>A	uc001qnx.2	-	6	1405	c.1116C>T	c.(1114-1116)GGC>GGT	p.G372G	SCNN1A_uc001qnv.2_Silent_p.G72G|SCNN1A_uc001qnw.2_Silent_p.G431G|SCNN1A_uc010sfb.1_Silent_p.G395G	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	372	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	AGGTCTCCACGCCAGGCCGCA	0.612													A	6464465	A	A	6464465	2	1	129	1	0	0	0	0	0	0	0	1	13927	1074	38	1		1	SCNN1A	12	6464465	Silent	SNP	G	TCGA-14-0787-01A-01W-0424-08		6464465	127387430	29	8853											
MYO1A	4640	broad.mit.edu	37	chr12	57424856	57424856	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gaagagctgctgcagctcctGatttgctgtgctgaggcact	13	10	0	3			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr12:57424856G>C	uc001smw.3	-	23	2695	c.2452C>G	c.(2452-2454)CAG>GAG	p.Q818E	MYO1A_uc010sqz.1_Missense_Mutation_p.Q656E|MYO1A_uc009zpd.2_Missense_Mutation_p.Q818E	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	818					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						TGCAGCTCCTGATTTGCTGTG	0.517													C	57424856	C	C	57424856	3	2	129	1	0	0	0	0	1	0	0	0	10068	1299	45	5	703	5	MYO1A	12	57424856	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08	50960391	57424856	76427039	30	8854											
NAV3	89795	broad.mit.edu	37	chr12	78574731	78574731	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctaagcctactcggccaccGtcagaatcctcaagcagcac	8	16	2	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr12:78574731G>A	uc001syp.2	+	30	5771	c.5598G>A	c.(5596-5598)CCG>CCA	p.P1866P	NAV3_uc001syo.2_Silent_p.P1844P|NAV3_uc010sub.1_Silent_p.P1323P|NAV3_uc009zsf.2_Silent_p.P675P	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1866						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTCGGCCACCGTCAGAATCCT	0.433										HNSCC(70;0.22)			A	78574731	A	A	78574731	2	1	129	1	0	0	0	0	0	0	0	1	10185	1132	40	1		1	NAV3	12	78574731	Silent	SNP	G	TCGA-14-0787-01A-01W-0424-08	21149875	78574731	55277164	31	8855											
OR4N2	390429	broad.mit.edu	37	chr14	20296487	20296487	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atacccttcgcaaccaggaaGtgaaagcttccatgaaaaag	8	10	0	2			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr14:20296487G>A	uc010tkv.1	+	1	880	c.880G>A	c.(880-882)GTG>ATG	p.V294M		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAACCAGGAAGTGAAAGCTTC	0.383													A	20296487	A	A	20296487	3	1	129	1	0	0	0	0	1	0	0	0	11077	1029	36	3	882	3	OR4N2	14	20296487	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08		20296487	87053053	32	8856											
CLEC14A	161198	broad.mit.edu	37	chr14	38723845	38723845	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tccccgactttcaccccattGtttgtgcaatgtgcagaact	7	13	1	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr14:38723845G>T	uc001wum.1	-	1	1730	c.1383C>A	c.(1381-1383)AAC>AAA	p.N461K		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	461	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCACCCCATTGTTTGTGCAAT	0.607													T	38723845	T	T	38723845	3	4	129	1	0	0	0	0	1	0	0	0	3499	1368	48	5	93	5	CLEC14A	14	38723845	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08	18427358	38723845	68625695	33	8857											
PYGL	5836	broad.mit.edu	37	chr14	51387718	51387718	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcccgagcagaccagaggCgcatggtgttgacagtgtta	15	9	0	3			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr14:51387718C>T	uc001wyu.2	-	6	855	c.728G>A	c.(727-729)CGC>CAC	p.R243H	PYGL_uc010tqq.1_Missense_Mutation_p.R209H|PYGL_uc001wyv.2_5'UTR|PYGL_uc010anz.1_Missense_Mutation_p.R46H	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	243					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	AGACCAGAGGCGCATGGTGTT	0.502													T	51387718	T	T	51387718	3	4	129	1	0	0	0	0	1	0	0	0	12861	768	27	1	1875	1	PYGL	14	51387718	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08	12663873	51387718	55961822	34	8858											
SMOC1	64093	broad.mit.edu	37	chr14	70442486	70442486	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtgtcaccccggatgggaagCccatcagtggctcttctgtg	13	12	4	0			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr14:70442486C>A	uc001xls.1	+	4	686	c.433C>A	c.(433-435)CCC>ACC	p.P145T	SMOC1_uc001xlt.1_Missense_Mutation_p.P145T	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	145	Thyroglobulin type-1 1.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		GGATGGGAAGCCCATCAGTGG	0.517													A	70442486	A	A	70442486	3	1	129	1	0	0	0	0	1	0	0	0	14801	739	26	5	447	5	SMOC1	14	70442486	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08	19054768	70442486	36907054	35	8859											
C15orf2	23742	broad.mit.edu	37	chr15	24921536	24921536	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatcgaaggggaggatgaCgagaaaaggaccccccttag	14	9	0	3			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr15:24921536C>T	uc001ywo.2	+	1	996	c.522C>T	c.(520-522)GAC>GAT	p.D174D		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	174					cell differentiation|multicellular organismal development|spermatogenesis			p.D174D(1)		ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GGGAGGATGACGAGAAAAGGA	0.622													T	24921536	T	T	24921536	2	4	129	1	0	0	0	0	0	0	0	1	1784	535	19	1		1	C15orf2	15	24921536	Silent	SNP	C	TCGA-14-0787-01A-01W-0424-08		24921536	77609856	36	8860											
SEC14L5	9717	broad.mit.edu	37	chr16	5046964	5046964	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggcgcaagcagcaccagGtggatctcctccttcagacc	11	15	2	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr16:5046964G>A	uc002cye.2	+	8	1069	c.889G>A	c.(889-891)GTG>ATG	p.V297M		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	297						integral to membrane|intracellular	transporter activity				0						GCAGCACCAGGTGGATCTCCT	0.612													A	5046964	A	A	5046964	3	1	129	1	0	0	0	0	1	0	0	0	13985	1261	44	3	915	3	SEC14L5	16	5046964	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08		5046964	85307789	37	8861											
ZFP90	146198	broad.mit.edu	37	chr16	68596966	68596966	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gactggaagaccaggcctgaAgtcaaatcatcacatttgca	9	10	3	2			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr16:68596966A>T	uc010cff.2	+	5	568	c.276A>T	c.(274-276)GAA>GAT	p.E92D	ZFP90_uc002ewb.2_Translation_Start_Site|ZFP90_uc002ewc.2_Translation_Start_Site|ZFP90_uc002ewd.2_Missense_Mutation_p.E92D|ZFP90_uc002ewe.2_Missense_Mutation_p.E92D	NM_133458	NP_597715	Q8TF47	ZFP90_HUMAN	zinc finger protein 90	92					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CCAGGCCTGAAGTCAAATCAT	0.423													T	68596966	T	T	68596966	3	4	129	1	0	0	0	0	1	0	0	0	17651	69	3	5	290	5	ZFP90	16	68596966	Missense_Mutation	SNP	A	TCGA-14-0787-01A-01W-0424-08	63550002	68596966	21757787	38	8862											
GPR179	440435	broad.mit.edu	37	chr17	36486234	36486234	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaacaggggccttgaggctgTgggatttagggaagatcttg	17	5	1	2			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr17:36486234T>C	uc002hpz.2	-	11	3239	c.3218A>G	c.(3217-3219)CAC>CGC	p.H1073R		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1073	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CTTGAGGCTGTGGGATTTAGG	0.567													C	36486234	C	C	36486234	3	2	129	1	0	0	0	0	1	0	0	0	6674	1696	59	4	3889	4	GPR179	17	36486234	Missense_Mutation	SNP	T	TCGA-14-0787-01A-01W-0424-08		36486234	44708976	39	8863											
CDH7	1005	broad.mit.edu	37	chr18	63476948	63476948	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atttttcaccagcttcactcTgatgttgataaaggagatgg	9	7	3	3			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr18:63476948T>C	uc002ljz.2	+	3	544	c.219T>C	c.(217-219)TCT>TCC	p.S73S	CDH7_uc002lka.2_Silent_p.S73S|CDH7_uc002lkb.2_Silent_p.S73S	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	73	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				AGCTTCACTCTGATGTTGATA	0.378													C	63476948	C	C	63476948	2	2	129	1	0	0	0	0	0	0	0	1	3115	1567	55	4		4	CDH7	18	63476948	Silent	SNP	T	TCGA-14-0787-01A-01W-0424-08		63476948	14600300	40	8864											
NFIC	4782	broad.mit.edu	37	chr19	3449019	3449019	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcccctccacaggcatctcGtccccggtgaagaagacaga	9	15	1	4			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr19:3449019G>A	uc010xhi.1	+	7	1028	c.966G>A	c.(964-966)TCG>TCA	p.S322S	NFIC_uc002lxo.2_Silent_p.S313S|NFIC_uc010xhh.1_Silent_p.S313S|NFIC_uc002lxp.2_Silent_p.S322S|NFIC_uc010xhj.1_Silent_p.S322S	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	322					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		CAGGCATCTCGTCCCCGGTGA	0.632													A	3449019	A	A	3449019	2	1	129	1	0	0	0	0	0	0	0	1	10372	1132	40	1		1	NFIC	19	3449019	Silent	SNP	G	TCGA-14-0787-01A-01W-0424-08		3449019	55679964	41	8865											
TYK2	7297	broad.mit.edu	37	chr19	10467283	10467283	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggtcacgcaggatggtgcGgaatgatggcctctgggttg	18	7	2	1			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr19:10467283G>A	uc002moc.3	-	18	2956	c.2578C>T	c.(2578-2580)CGC>TGC	p.R860C	TYK2_uc010dxe.2_Missense_Mutation_p.R675C	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	860	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			AGGATGGTGCGGAATGATGGC	0.662													A	10467283	A	A	10467283	3	1	129	1	0	0	0	0	1	0	0	0	16807	1116	39	2	1017	2	TYK2	19	10467283	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08	7018264	10467283	48661700	42	8866											
SARS2	54938	broad.mit.edu	37	chr19	39408365	39408365	+	Frame_Shift_Del	DEL	G	-	-													ccctggcccctctccacaccGgaagtgcaagcccagctctg							TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr19:39408365delG	uc002oka.2	-	12	1319	c.1159delC	c.(1159-1161)CGGfs	p.R387fs	SARS2_uc002ojz.2_Frame_Shift_Del_p.R197fs|SARS2_uc010xup.1_Frame_Shift_Del_p.R389fs|SARS2_uc002okb.2_Frame_Shift_Del_p.R387fs|SARS2_uc010xuq.1_Frame_Shift_Del_p.R387fs|SARS2_uc010xur.1_RNA	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	387					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			TCTCCACACCGGAAGTGCAAG	0.637													-	39408365	-	-	39408365	7	5	129	1	0	1	0	1	0	0	0	0	13845	1130	39	0	417	0	SARS2	19	39408365	Frame_Shift_Del	DEL	G	TCGA-14-0787-01A-01W-0424-08	28941082	39408365	19720618	43	8867											
ZNF610	162963	broad.mit.edu	37	chr19	52869863	52869863	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtgacaaagtctttgggcGcaaattatacctaaccaacc	7	10	1	1	rs150692972		TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr19:52869863G>A	uc002pyx.3	+	6	1638	c.1232G>A	c.(1231-1233)CGC>CAC	p.R411H	ZNF610_uc002pyy.3_Missense_Mutation_p.R411H|ZNF610_uc002pyz.3_Missense_Mutation_p.R368H|ZNF610_uc002pza.2_Missense_Mutation_p.R411H	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	411	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GTCTTTGGGCGCAAATTATAC	0.423													A	52869863	A	A	52869863	3	1	129	1	0	0	0	0	1	0	0	0	18033	1087	38	1	1246	1	ZNF610	19	52869863	Missense_Mutation	SNP	G	TCGA-14-0787-01A-01W-0424-08	13461498	52869863	6259120	44	8868											
KIR2DL1	3802	broad.mit.edu	37	chr19	55284986	55284986	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctccatcagtcgcatgaCgcaagacctggcagggacct	10	14	2	2	rs117204680	byFrequency	TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr19:55284986C>T	uc002qhb.1	+	3	310	c.272C>T	c.(271-273)ACG>ATG	p.T91M	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.T91M	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	91	Extracellular (Potential).|Ig-like C2-type 1.				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		AGTCGCATGACGCAAGACCTG	0.532													T	55284986	T	T	55284986	3	4	129	1	0	0	0	0	1	0	0	0	8316	536	19	1	282	1	KIR2DL1	19	55284986	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08	2415123	55284986	3843997	45	8869											
APOBEC3A	200315	broad.mit.edu	37	chr22	39357613	39357613	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcccgcatctatgattaCgaccccctatataaggaggc	9	13	1	1	rs141631289		TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chr22:39357613C>T	uc003awn.2	+	3	566	c.396C>T	c.(394-396)TAC>TAT	p.Y132Y	APOBEC3A_uc011aob.1_Silent_p.Y114Y|APOBEC3A_uc011aoc.1_Silent_p.Y132Y	NM_145699	NP_663745	P31941	ABC3A_HUMAN	phorbolin 1	132					cellular response to xenobiotic stimulus|defense response to virus|DNA cytosine deamination|DNA demethylation|innate immune response|negative regulation of transposition|negative regulation of viral genome replication	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					TCTATGATTACGACCCCCTAT	0.572													T	39357613	T	T	39357613	2	4	129	1	0	0	0	0	0	0	0	1	789	547	19	1		1	APOBEC3A	22	39357613	Silent	SNP	C	TCGA-14-0787-01A-01W-0424-08		39357613	11946953	46	8870											
RLIM	51132	broad.mit.edu	37	chrX	73811411	73811411	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagtttacgaagtttgttgCcttctgtatattctgtaatg	9	5	2	0			TCGA-14-0787-01A-01W-0424-08	TCGA-14-0787-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	184b240c-ebf1-4ecf-87eb-aae0718cd81f	160d43cf-950b-4476-aaec-6d9be41de861	g.chrX:73811411C>T	uc004ebu.2	-	5	2029	c.1739G>A	c.(1738-1740)GGC>GAC	p.G580D	RLIM_uc004ebw.2_Missense_Mutation_p.G580D	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	580	RING-type.				random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						AAGTTTGTTGCCTTCTGTATA	0.408													T	73811411	T	T	73811411	3	4	129	1	0	0	0	0	1	0	0	0	13390	739	26	3	139	3	RLIM	23	73811411	Missense_Mutation	SNP	C	TCGA-14-0787-01A-01W-0424-08		73811411	81459149	47	8871											
CHD5	26038	broad.mit.edu	37	chr1	6189033	6189033	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagcatcatcttgcgcttggCcacctgcgtgatgcgctcct	11	14	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:6189033C>A	uc001amb.1	-	23	3584	c.3484G>T	c.(3484-3486)GCC>TCC	p.A1162S	CHD5_uc001alz.1_Missense_Mutation_p.A19S|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1162	Helicase C-terminal.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TTGCGCTTGGCCACCTGCGTG	0.642													A	6189033	A	A	6189033	3	1	130	1	0	0	0	0	1	0	0	0	3328	739	26	5	2456	5	CHD5	1	6189033	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08		6189033	243061588	1	8872											
MRTO4	51154	broad.mit.edu	37	chr1	19584462	19584462	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaggcagctgggcctgccCaccgccctcaagagaggtat	12	15	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:19584462C>T	uc001bbs.2	+	6	732	c.477C>T	c.(475-477)CCC>CCT	p.P159P		NM_016183	NP_057267	Q9UKD2	MRT4_HUMAN	mRNA turnover 4 homolog	159					ribosome biogenesis	nuclear membrane|nucleolus					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.87e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00301)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGCCTGCCCACCGCCCTCA	0.592													T	19584462	T	T	19584462	2	4	130	1	0	0	0	0	0	0	0	1	9852	581	21	3		3	MRTO4	1	19584462	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	13395429	19584462	229666159	2	8873											
HPCAL4	51440	broad.mit.edu	37	chr1	40149794	40149794	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgcggaaagcgtgctgcgCgaacttggaggcgtcgccgt	18	10	0	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:40149794C>T	uc001cdr.2	-	3	313	c.193G>A	c.(193-195)GCG>ACG	p.A65T	HPCAL4_uc010oix.1_Intron	NM_016257	NP_057341	Q9UM19	HPCL4_HUMAN	hippocalcin-like protein 4	65	EF-hand 2.				central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCGTGCTGCGCGAACTTGGAG	0.682													T	40149794	T	T	40149794	3	4	130	1	0	0	0	0	1	0	0	0	7331	768	27	1	390	1	HPCAL4	1	40149794	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	20565332	40149794	209100827	3	8874											
C1orf177	163747	broad.mit.edu	37	chr1	55277777	55277777	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgaccttgagacatatgtggCacgatccgtcggcacccgcg	12	14	0	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:55277777C>A	uc001cyb.3	+	6	731	c.677C>A	c.(676-678)GCA>GAA	p.A226E	C1orf177_uc001cya.3_Missense_Mutation_p.A226E	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	226											0						ACATATGTGGCACGATCCGTC	0.592													A	55277777	A	A	55277777	3	1	130	1	0	0	0	0	1	0	0	0	2017	710	25	5	699	5	C1orf177	1	55277777	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	15127983	55277777	193972844	4	8875											
GPSM2	29899	broad.mit.edu	37	chr1	109472462	109472462	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acagagagttcttttacaaaGagatcaaaacagagacactg	8	7	2	3			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:109472462G>C	uc010ovc.1	+	15	2451	c.1955G>C	c.(1954-1956)AGA>ACA	p.R652T	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Missense_Mutation_p.R652T|GPSM2_uc010ove.1_Missense_Mutation_p.R652T|CLCC1_uc001dwe.1_3'UTR|CLCC1_uc001dwf.1_3'UTR|CLCC1_uc001dwg.1_3'UTR	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	652					G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		CTTTTACAAAGAGATCAAAAC	0.398													C	109472462	C	C	109472462	3	2	130	1	0	0	0	0	1	0	0	0	6735	942	33	5	2009	5	GPSM2	1	109472462	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	54194685	109472462	139778159	5	8876											
ZNF697	90874	broad.mit.edu	37	chr1	120165477	120165477	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gataaagctcttgccgcactCgatgcacgtgtagggcttct	11	11	2	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:120165477C>T	uc001ehy.1	-	3	1603	c.1489G>A	c.(1489-1491)GAG>AAG	p.E497K		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	497	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		TTGCCGCACTCGATGCACGTG	0.647													T	120165477	T	T	120165477	3	4	130	1	0	0	0	0	1	0	0	0	18097	893	31	2	152	2	ZNF697	1	120165477	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	10693015	120165477	129085144	6	8877											
PDE4DIP	9659	broad.mit.edu	37	chr1	144886204	144886204	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtgctggtggaactcagcCctcaggtggagcatttcttc	12	10	3	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:144886204C>T	uc001elw.3	-	23	3321	c.3030G>A	c.(3028-3030)AGG>AGA	p.R1010R	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.R1076R|PDE4DIP_uc001elv.3_Silent_p.R17R	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1010	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GGAACTCAGCCCTCAGGTGGA	0.522			T	PDGFRB	MPD								T	144886204	T	T	144886204	2	4	130	1	0	0	0	0	0	0	0	1	11643	622	22	3		3	PDE4DIP	1	144886204	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	24720727	144886204	104364417	7	8878											
LINGO4	339398	broad.mit.edu	37	chr1	151774395	151774395	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagggcaccgagctcagattGcagcgagtgatggccaggct	15	10	1	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:151774395G>A	uc001ezf.1	-	2	976	c.786C>T	c.(784-786)TGC>TGT	p.C262C		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	262	Extracellular (Potential).|LRR 8.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGCTCAGATTGCAGCGAGTGA	0.607													A	151774395	A	A	151774395	2	1	130	1	0	0	0	0	0	0	0	1	8817	1311	46	3		3	LINGO4	1	151774395	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08	6888191	151774395	97476226	8	8879											
FLG2	388698	broad.mit.edu	37	chr1	152329096	152329096	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttgaccattactacaagacTggctacctccagacccatat	6	13	0	3			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:152329096T>G	uc001ezw.3	-	3	1239	c.1166A>C	c.(1165-1167)CAG>CCG	p.Q389P	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	389	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTACAAGACTGGCTACCTCC	0.443													G	152329096	G	G	152329096	3	3	130	1	0	0	0	0	1	0	0	0	5923	1580	55	5	6013	5	FLG2	1	152329096	Missense_Mutation	SNP	T	TCGA-14-0789-01A-01W-0424-08	554701	152329096	96921525	9	8880											
CRNN	49860	broad.mit.edu	37	chr1	152383181	152383181	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cataatgctgccctttccccGcccttcccacttcagtgcca	5	19	1	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:152383181G>A	uc001ezx.2	-	3	451	c.377C>T	c.(376-378)GCG>GTG	p.A126V		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	126					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTTTCCCCGCCCTTCCCAC	0.637													A	152383181	A	A	152383181	3	1	130	1	0	0	0	0	1	0	0	0	3892	1087	38	1	1114	1	CRNN	1	152383181	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	54085	152383181	96867440	10	8881											
S100A7A	338324	broad.mit.edu	37	chr1	153390660	153390660	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagaagccaagcctgctgacGatgatgaaggagaacttccc	12	10	0	5			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:153390660G>A	uc001fbt.1	+	2	159	c.102G>A	c.(100-102)ACG>ACA	p.T34T		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	34	EF-hand 1.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCTGCTGACGATGATGAAGG	0.483													A	153390660	A	A	153390660	2	1	130	1	0	0	0	0	0	0	0	1	13784	1045	37	2		2	S100A7A	1	153390660	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08	1007479	153390660	95859961	11	8882											
HMCN1	83872	broad.mit.edu	37	chr1	186052023	186052023	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	aatactcaaataacagatatCggcaggtatgtgtgtgttgc	10	6	1	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:186052023C>A	uc001grq.1	+	57	9043	c.8814C>A	c.(8812-8814)ATC>ATA	p.I2938I		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2938	Ig-like C2-type 27.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TAACAGATATCGGCAGGTATG	0.323													A	186052023	A	A	186052023	2	1	130	1	0	0	0	0	0	0	0	1	7220	874	31	5		5	HMCN1	1	186052023	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	32661363	186052023	63198598	12	8883											
HHIPL2	79802	broad.mit.edu	37	chr1	222713493	222713493	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccacagaatatccggcctcGgccctggcgcgtgatggggt	14	14	0	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:222713493G>A	uc001hnh.1	-	4	1367	c.1309C>T	c.(1309-1311)CGA>TGA	p.R437*		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	437					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		ATCCGGCCTCGGCCCTGGCGC	0.577													A	222713493	A	A	222713493	4	1	130	1	0	0	0	0	0	1	0	0	7094	1124	39	2	889	2	HHIPL2	1	222713493	Nonsense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	36661470	222713493	26537128	13	8884											
RYR2	6262	broad.mit.edu	37	chr1	237802413	237802413	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggagaaggtgggaatgggCttcttgcagcaatggaagaa	17	4	1	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr1:237802413C>T	uc001hyl.1	+	46	7147	c.7027C>T	c.(7027-7029)CTT>TTT	p.L2343F		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2343	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGGAATGGGCTTCTTGCAGC	0.498													T	237802413	T	T	237802413	3	4	130	1	0	0	0	0	1	0	0	0	13769	797	28	3	7209	3	RYR2	1	237802413	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	15088920	237802413	11448208	14	8885											
RAD51AP2	729475	broad.mit.edu	37	chr2	17698942	17698942	+	Frame_Shift_Del	DEL	T	-	-													ctatctctaaaatagctaggTttggcaatttccaagctggg							TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr2:17698942delT	uc002rcl.1	-	1	765	c.741delA	c.(739-741)AAAfs	p.K247fs	RAD51AP2_uc010exn.1_Frame_Shift_Del_p.K238fs	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	247										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AATAGCTAGGTTTGGCAATTT	0.353													-	17698942	-	-	17698942	7	5	130	1	0	1	0	1	0	0	0	0	12987	1722	60	0	2750	0	RAD51AP2	2	17698942	Frame_Shift_Del	DEL	T	TCGA-14-0789-01A-01W-0424-08		17698942	225500431	15	8886											
ADCY3	109	broad.mit.edu	37	chr2	25095488	25095489	+	Frame_Shift_Ins	INS	-	G	G													cttcacctccagcgactggcINSgggcctccaggaaggccttg							TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr2:25095488_25095489insG	uc002rfs.3	-	2	974_975	c.775_776insC	c.(775-777)CGCfs	p.R259fs	ADCY3_uc010ykm.1_Frame_Shift_Ins_p.R259fs	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	259					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					CAGCGACTGGCGGGCCTCCAGG	0.634													G	25095489	G	G	25095488	7	5	130	1	0	1	1	0	0	0	0	0	295	768	27	0	2738	0	ADCY3	2	25095488	Frame_Shift_Ins	INS	-	TCGA-14-0789-01A-01W-0424-08	7396546	25095488	218103885	16	8887											
PLB1	151056	broad.mit.edu	37	chr2	28761204	28761204	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaatgggcttgcggcgggcGgcgtggatgagctgatgggg	22	6	0	3	rs149462466		TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr2:28761204G>A	uc002rmb.1	+	10	574	c.574G>A	c.(574-576)GGC>AGC	p.G192S	PLB1_uc010ezj.1_Missense_Mutation_p.G203S	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	192	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					TGCGGCGGGCGGCGTGGATGA	0.642													A	28761204	A	A	28761204	3	1	130	1	0	0	0	0	1	0	0	0	12024	1116	39	2	645	2	PLB1	2	28761204	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	3665716	28761204	214438169	17	8888											
LRP1B	53353	broad.mit.edu	37	chr2	141081530	141081530	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caatatttaaagctaagtacTctactgaaccatggccaaat	5	9	1	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr2:141081530T>C	uc002tvj.1	-	81	13418	c.12446A>G	c.(12445-12447)GAG>GGG	p.E4149G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4149	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.E4149*(1)		lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGCTAAGTACTCTACTGAACC	0.289										TSP Lung(27;0.18)			C	141081530	C	C	141081530	3	2	130	1	0	0	0	0	1	0	0	0	8955	1551	54	4	1397	4	LRP1B	2	141081530	Missense_Mutation	SNP	T	TCGA-14-0789-01A-01W-0424-08	112320326	141081530	102117843	18	8889											
SGOL2	151246	broad.mit.edu	37	chr2	201437974	201437974	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atatggaagtcaacagtaatGaaaaggaaagttgtgatcaa	10	3	2	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr2:201437974G>A	uc002uvw.2	+	7	3018	c.2905G>A	c.(2905-2907)GAA>AAA	p.E969K	SGOL2_uc010zhd.1_Missense_Mutation_p.E969K|SGOL2_uc010zhe.1_Missense_Mutation_p.E969K	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	969					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						CAACAGTAATGAAAAGGAAAG	0.274													A	201437974	A	A	201437974	3	1	130	1	0	0	0	0	1	0	0	0	14217	1291	45	3	2927	3	SGOL2	2	201437974	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	60356444	201437974	41761399	19	8890											
SP140	11262	broad.mit.edu	37	chr2	231109774	231109774	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gagatgctgaagatgcacccAgcctactaccaggtggggga	14	10	0	3			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr2:231109774A>T	uc002vql.2	+	6	758	c.643A>T	c.(643-645)AGC>TGC	p.S215C	SP140_uc010zma.1_RNA|SP140_uc002vqk.2_Missense_Mutation_p.S215C|SP140_uc002vqn.2_Missense_Mutation_p.S215C|SP140_uc002vqm.2_Missense_Mutation_p.S215C|SP140_uc010fxl.2_Missense_Mutation_p.S215C	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	215					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGATGCACCCAGCCTACTACC	0.443													T	231109774	T	T	231109774	3	4	130	1	0	0	0	0	1	0	0	0	14962	188	7	5	782	5	SP140	2	231109774	Missense_Mutation	SNP	A	TCGA-14-0789-01A-01W-0424-08	29671800	231109774	12089599	20	8891											
UGT1A10	54575	broad.mit.edu	37	chr2	234545195	234545195	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcgcagggtggaccagcccCgttcctttatgtgtgtgtct	13	12	1	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr2:234545195C>T	uc002vur.2	+	1	73	c.27C>T	c.(25-27)CCC>CCT	p.P9P	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Silent_p.P9P	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	9				MARAGWTSPVPLCVCLLLTCGFA -> MAPRRVDQPRSFMC VSTADLWLC (in Ref. 1).	flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		GGACCAGCCCCGTTCCTTTAT	0.572													T	234545195	T	T	234545195	2	4	130	1	0	0	0	0	0	0	0	1	16942	639	23	2		2	UGT1A10	2	234545195	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	3435421	234545195	8654178	21	8892											
CHL1	10752	broad.mit.edu	37	chr3	405060	405060	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cagtcacagccaatttggatAttagaagtatttttatttca	6	6	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr3:405060A>T	uc003bou.2	+	13	1802	c.1531A>T	c.(1531-1533)ATT>TTT	p.I511F	CHL1_uc003bot.2_Missense_Mutation_p.I527F|CHL1_uc003bow.1_Missense_Mutation_p.I511F|CHL1_uc011asi.1_Missense_Mutation_p.I527F|uc003box.1_RNA	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	511	Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAATTTGGATATTAGAAGTAT	0.378													T	405060	T	T	405060	3	4	130	1	0	0	0	0	1	0	0	0	3349	449	16	5	1625	5	CHL1	3	405060	Missense_Mutation	SNP	A	TCGA-14-0789-01A-01W-0424-08		405060	197617370	22	8893											
CACNA2D3	55799	broad.mit.edu	37	chr3	54930849	54930849	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctctggtaccgaagagccGctgagcagattccagggagc	13	12	1	3			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr3:54930849G>A	uc003dhf.2	+	26	2368	c.2320G>A	c.(2320-2322)GCT>ACT	p.A774T	CACNA2D3_uc003dhg.1_Missense_Mutation_p.A680T|CACNA2D3_uc003dhh.1_RNA|uc003dhk.1_RNA	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	774	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity	p.A774T(1)		large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CCGAAGAGCCGCTGAGCAGAT	0.537													A	54930849	A	A	54930849	3	1	130	1	0	0	0	0	1	0	0	0	2550	1087	38	1	2422	1	CACNA2D3	3	54930849	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	54525789	54930849	143091581	23	8894											
PIK3CB	5291	broad.mit.edu	37	chr3	138417859	138417859	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agtccaaataagatccatttCattttcacacagttgagaca	5	9	2	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr3:138417859C>T	uc011bmq.1	-	11	1660	c.1660G>A	c.(1660-1662)GAA>AAA	p.E554K	PIK3CB_uc011bmn.1_Missense_Mutation_p.E66K|PIK3CB_uc011bmo.1_5'UTR|PIK3CB_uc011bmp.1_Missense_Mutation_p.E141K	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	554	PI3K helical.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AGATCCATTTCATTTTCACAC	0.383													T	138417859	T	T	138417859	3	4	130	1	0	0	0	0	1	0	0	0	11914	835	29	3	1598	3	PIK3CB	3	138417859	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	83487010	138417859	59604571	24	8895											
IDUA	3425	broad.mit.edu	37	chr4	995507	995507	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctgctcggagggtctgcgCgccgccagccccgccctgcg	15	19	1	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr4:995507C>T	uc003gby.2	+	6	718	c.630C>T	c.(628-630)CGC>CGT	p.R210R	IDUA_uc003gbz.2_RNA|IDUA_uc003gca.2_Silent_p.R163R	NM_000203	NP_000194	P35475	IDUA_HUMAN	alpha-L-iduronidase precursor	210					disaccharide metabolic process	lysosome	cation binding|L-iduronidase activity				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)		Laronidase(DB00090)	AGGGTCTGCGCGCCGCCAGCC	0.716													T	995507	T	T	995507	2	4	130	1	0	0	0	0	0	0	0	1	7504	755	27	1		1	IDUA	4	995507	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08		995507	190158769	25	8896											
TLR10	81793	broad.mit.edu	37	chr4	38777060	38777060	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tataggataaatccagtgtcGttgtggctggggtcaagtct	13	6	2	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr4:38777060G>A	uc003gti.2	-	2	531	c.152C>T	c.(151-153)ACG>ATG	p.T51M	TLR10_uc003gtj.2_Missense_Mutation_p.T51M|TLR10_uc003gtk.2_Missense_Mutation_p.T51M	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	51	Extracellular (Potential).|LRR 2.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						ATCCAGTGTCGTTGTGGCTGG	0.448													A	38777060	A	A	38777060	3	1	130	1	0	0	0	0	1	0	0	0	15947	1145	40	1	2287	1	TLR10	4	38777060	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	37781553	38777060	152377216	26	8897											
CCDC158	339965	broad.mit.edu	37	chr4	77304876	77304876	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgattcagatttcagtgcttCaagttgatcctctacctggt	8	9	4	3			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr4:77304876C>T	uc003hkb.3	-	6	895	c.742G>A	c.(742-744)GAA>AAA	p.E248K	CCDC158_uc003hkd.2_Missense_Mutation_p.E248K	NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	248	Potential.									skin(3)|ovary(2)|pancreas(1)	6						TTCAGTGCTTCAAGTTGATCC	0.368													T	77304876	T	T	77304876	3	4	130	1	0	0	0	0	1	0	0	0	2790	835	29	3	2675	3	CCDC158	4	77304876	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	38527816	77304876	113849400	27	8898											
SPARCL1	8404	broad.mit.edu	37	chr4	88420673	88420673	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagaagaaaggaaatttacCgggattgcagctgcagttcc	11	8	0	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr4:88420673C>T	uc010ikm.2	-	3	626	c.54G>A	c.(52-54)CCG>CCA	p.P18P	SPARCL1_uc011cdc.1_Intron|SPARCL1_uc003hqs.3_Silent_p.P18P|SPARCL1_uc011cdd.1_5'UTR|SPARCL1_uc003hqt.2_Silent_p.P18P	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	18					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		GGAAATTTACCGGGATTGCAG	0.363													T	88420673	T	T	88420673	2	4	130	1	0	0	0	0	0	0	0	1	14995	666	23	2		2	SPARCL1	4	88420673	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	11115797	88420673	102733603	28	8899											
FGA	2243	broad.mit.edu	37	chr4	155507297	155507297	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgaccagtttttctgtgtgGtactctctccttgtccctgg	10	11	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr4:155507297G>T	uc003iod.1	-	5	1342	c.1284C>A	c.(1282-1284)TAC>TAA	p.Y428*	FGA_uc003ioe.1_Nonsense_Mutation_p.Y428*|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	428	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTTCTGTGTGGTACTCTCTCC	0.512													T	155507297	T	T	155507297	4	4	130	1	0	0	0	0	0	1	0	0	5830	1256	44	5	1368	5	FGA	4	155507297	Nonsense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	67086624	155507297	35646979	29	8900											
THBS4	7060	broad.mit.edu	37	chr5	79378941	79378941	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccaagagtttcaaacccagAatttcgaccgcttcgataat	6	11	1	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr5:79378941A>G	uc003kgh.2	+	23	3186	c.2863A>G	c.(2863-2865)AAT>GAT	p.N955D	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	955					endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		TCAAACCCAGAATTTCGACCG	0.453											OREG0016685	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	79378941	G	G	79378941	3	3	130	1	0	0	0	0	1	0	0	0	15853	246	9	4	2949	4	THBS4	5	79378941	Missense_Mutation	SNP	A	TCGA-14-0789-01A-01W-0424-08		79378941	101536319	30	8901											
HARS	3035	broad.mit.edu	37	chr5	140053903	140053903	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctccacaaggtcttctcttCggacatccacctggccagga	8	16	2	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr5:140053903C>T	uc003lgv.2	-	13	1551	c.1469G>A	c.(1468-1470)CGA>CAA	p.R490Q	DND1_uc003lgt.2_5'Flank|HARS_uc003lgu.2_Missense_Mutation_p.R421Q|HARS_uc011czm.1_Missense_Mutation_p.R450Q|HARS_uc003lgw.2_Missense_Mutation_p.R470Q|HARS_uc011czn.1_Missense_Mutation_p.R430Q|HARS_uc010jfu.2_Missense_Mutation_p.R402Q|HARS_uc011czo.1_Missense_Mutation_p.R416Q|HARS_uc011czp.1_Missense_Mutation_p.R376Q	NM_002109	NP_002100	P12081	SYHC_HUMAN	histidyl-tRNA synthetase	490					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	GTCTTCTCTTCGGACATCCAC	0.522													T	140053903	T	T	140053903	3	4	130	1	0	0	0	0	1	0	0	0	6959	884	31	2	64	2	HARS	5	140053903	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	60674962	140053903	40861357	31	8902											
PCDHA2	56146	broad.mit.edu	37	chr5	140174750	140174750	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcgcctgttccgggtggcGtccaaaagacacggggacct	14	14	0	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr5:140174750G>A	uc003lhd.2	+	1	307	c.201G>A	c.(199-201)GCG>GCA	p.A67A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.A67A|PCDHA2_uc011czy.1_Silent_p.A67A	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	67	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCGGGTGGCGTCCAAAAGAC	0.647													A	140174750	A	A	140174750	2	1	130	1	0	0	0	0	0	0	0	1	11524	1132	40	1		1	PCDHA2	5	140174750	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08	120847	140174750	40740510	32	8903											
PCDHB4	56131	broad.mit.edu	37	chr5	140503471	140503471	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcaccgccaggctgctgagcGagcgcgacgcagccaagcac	14	16	0	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr5:140503471G>A	uc003lip.1	+	1	1891	c.1891G>A	c.(1891-1893)GAG>AAG	p.E631K		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	631	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGCTGAGCGAGCGCGACGC	0.687													A	140503471	A	A	140503471	3	1	130	1	0	0	0	0	1	0	0	0	11544	1059	37	2	1893	2	PCDHB4	5	140503471	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	328721	140503471	40411789	33	8904											
PRRT1	80863	broad.mit.edu	37	chr6	32118160	32118160	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctcaccgtgcccaccgggtaGaccggcacgtaagcagtgca	12	15	1	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr6:32118160G>A	uc003nzt.2	-	2	659	c.543C>T	c.(541-543)GTC>GTT	p.V181V	PRRT1_uc003nzs.2_Silent_p.V222V|PRRT1_uc003nzu.2_Silent_p.L74L	NM_030651	NP_085154	Q99946	PRRT1_HUMAN	NG5 protein	181					response to biotic stimulus	integral to membrane				breast(1)	1						CCACCGGGTAGACCGGCACGT	0.667													A	32118160	A	A	32118160	2	1	130	1	0	0	0	0	0	0	0	1	12609	929	33	3		3	PRRT1	6	32118160	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08		32118160	138996907	34	8905											
ITPR3	3710	broad.mit.edu	37	chr6	33633622	33633622	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcacccaggtttgtcatcCagctgctggaagacctggtg	11	13	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr6:33633622C>T	uc011drk.1	+	14	1639	c.1420C>T	c.(1420-1422)CAG>TAG	p.Q474*		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	474	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GTTTGTCATCCAGCTGCTGGA	0.572													T	33633622	T	T	33633622	4	4	130	1	0	0	0	0	0	1	0	0	7922	595	21	3	1474	3	ITPR3	6	33633622	Nonsense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	1515462	33633622	137481445	35	8906											
VEGFA	7422	broad.mit.edu	37	chr6	43748479	43748479	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tattttccagaaaatcagttCgaggaaagggaaaggggcaa	12	5	1	1	rs45533131		TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr6:43748479C>T	uc003owh.2	+	6	1464	c.973C>T	c.(973-975)CGA>TGA	p.R325*	VEGFA_uc003owd.2_Intron|VEGFA_uc003owf.2_Nonsense_Mutation_p.R325*|VEGFA_uc003owe.2_Intron|VEGFA_uc003owg.2_Nonsense_Mutation_p.R325*|VEGFA_uc003owi.2_Intron|VEGFA_uc003owj.2_Intron|VEGFA_uc010jyx.2_Intron|VEGFA_uc003owk.2_Intron	NM_001025366	NP_001020537	P15692	VEGFA_HUMAN	vascular endothelial growth factor A isoform a	145					basophil chemotaxis|cellular response to hypoxia|induction of positive chemotaxis|induction of positive chemotaxis|platelet activation|platelet degranulation|platelet-derived growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of leukocyte migration|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular permeability|regulation of cell shape|vascular endothelial growth factor receptor signaling pathway|vasculogenesis	cell surface|extracellular space|membrane|platelet alpha granule lumen	cell surface binding|chemoattractant activity|cytokine activity|fibronectin binding|growth factor activity|heparin binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor binding			ovary(1)|breast(1)	2	all_cancers(18;5.46e-07)|all_epithelial(2;5.96e-08)|Lung NSC(15;0.000157)|all_lung(25;0.000486)|Hepatocellular(11;0.00309)		all cancers(41;0.000413)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0742)|OV - Ovarian serous cystadenocarcinoma(102;0.196)		Atorvastatin(DB01076)|Bevacizumab(DB00112)|Carvedilol(DB01136)|Ginkgo biloba(DB01381)|Gliclazide(DB01120)|Minocycline(DB01017)|Ranibizumab(DB01270)|Simvastatin(DB00641)	AAAATCAGTTCGAGGAAAGGG	0.532													T	43748479	T	T	43748479	4	4	130	1	0	0	0	0	0	1	0	0	17147	876	31	2	995	2	VEGFA	6	43748479	Nonsense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	10114857	43748479	127366588	36	8907											
GPRC6A	222545	broad.mit.edu	37	chr6	117128089	117128089	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatgattttcttcagtgtcCgattgattctgacttcaatg	7	7	4	3			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr6:117128089C>T	uc003pxj.1	-	3	801	c.779G>A	c.(778-780)CGG>CAG	p.R260Q	GPRC6A_uc003pxk.1_Missense_Mutation_p.R260Q|GPRC6A_uc003pxl.1_Missense_Mutation_p.R260Q	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	260	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CTTCAGTGTCCGATTGATTCT	0.363													T	117128089	T	T	117128089	3	4	130	1	0	0	0	0	1	0	0	0	6728	652	23	2	2017	2	GPRC6A	6	117128089	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	73379610	117128089	53986978	37	8908											
LPA	4018	broad.mit.edu	37	chr6	161020531	161020531	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtaaagaacaaagacgtaCgcatttgggtagttttctgg	12	5	1	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr6:161020531C>T	uc003qtl.2	-	21	3407	c.3287_splice	c.e21+1	p.A1096_splice		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor						blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CAAAGACGTACGCATTTGGGT	0.483													T	161020531	T	T	161020531	5	4	130	1	0	0	0	0	0	0	1	0	8903	550	19	1	2914	1	LPA	6	161020531	Splice_Site	SNP	C	TCGA-14-0789-01A-01W-0424-08	43892442	161020531	10094536	38	8909											
EGFR	1956	broad.mit.edu	37	chr7	55238870	55238870	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctttcacttcctacagatGcactgggccaggtcttgaag	9	12	3	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr7:55238870G>A	uc003tqk.2	+	16	2129	c.1883G>A	c.(1882-1884)TGC>TAC	p.C628Y	EGFR_uc010kzg.1_Missense_Mutation_p.C583Y|EGFR_uc011kco.1_Missense_Mutation_p.C575Y|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	628	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCCTACAGATGCACTGGGCCA	0.393		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55238870	A	A	55238870	3	1	130	1	0	0	0	0	1	0	0	0	4967	1319	46	3	2209	3	EGFR	7	55238870	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08		55238870	103899793	39	8910											
CALN1	83698	broad.mit.edu	37	chr7	71252851	71252851	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcgcatatgaggctcttcCggacgcaggtctgtctgttc	13	11	3	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr7:71252851C>T	uc003twa.3	-	6	1096	c.569G>A	c.(568-570)CGG>CAG	p.R190Q	CALN1_uc003twb.3_Missense_Mutation_p.R232Q|CALN1_uc003twc.3_Missense_Mutation_p.R190Q	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	190	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				GAGGCTCTTCCGGACGCAGGT	0.552													T	71252851	T	T	71252851	3	4	130	1	0	0	0	0	1	0	0	0	2591	652	23	2	94	2	CALN1	7	71252851	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	16013981	71252851	87885812	40	8911											
GRM3	2913	broad.mit.edu	37	chr7	86415655	86415655	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaactcagtgataagtcgCgctatgattactttgccagg	9	10	1	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr7:86415655C>T	uc003uid.2	+	3	1646	c.547C>T	c.(547-549)CGC>TGC	p.R183C	GRM3_uc010lef.2_Missense_Mutation_p.R181C|GRM3_uc010leg.2_Missense_Mutation_p.R55C|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	183	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGATAAGTCGCGCTATGATTA	0.562													T	86415655	T	T	86415655	3	4	130	1	0	0	0	0	1	0	0	0	6798	768	27	1	553	1	GRM3	7	86415655	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	15162804	86415655	72723008	41	8912											
ABCB4	5244	broad.mit.edu	37	chr7	87092144	87092144	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccaaatactatcatcatgagGgggagacctgatccgtgagc	11	10	2	4			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr7:87092144G>T	uc003uiv.1	-	4	292	c.216C>A	c.(214-216)CCC>CCA	p.P72P	ABCB4_uc003uiw.1_Silent_p.P72P|ABCB4_uc003uix.1_Silent_p.P72P|ABCB4_uc003uiy.2_Silent_p.P72P	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	72	ABC transmembrane type-1 1.|Helical; (By similarity).			IMAIAHGSGLP -> RGSSRVDLQAC (in Ref. 5; CAA84542).	cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TCATCATGAGGGGGAGACCTG	0.383													T	87092144	T	T	87092144	2	4	130	1	0	0	0	0	0	0	0	1	43	1219	43	5		5	ABCB4	7	87092144	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08	676489	87092144	72046519	42	8913											
AZGP1	563	broad.mit.edu	37	chr7	99569626	99569626	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatataggtcagagagtaaCgacctgcaaaagaaaagatt	10	5	1	4			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr7:99569626C>T	uc003ush.2	-	2	124	c.80G>A	c.(79-81)CGT>CAT	p.R27H		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	27					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CAGAGAGTAACGACCTGCAAA	0.527													T	99569626	T	T	99569626	3	4	130	1	0	0	0	0	1	0	0	0	1239	536	19	1	828	1	AZGP1	7	99569626	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	12477482	99569626	59569037	43	8914											
ASB15	142685	broad.mit.edu	37	chr7	123269046	123269046	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctcattgaaaatggttttgAtgtcaacactctacttgctg	8	8	3	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr7:123269046A>G	uc003vku.1	+	10	1290	c.998A>G	c.(997-999)GAT>GGT	p.D333G	ASB15_uc003vkw.1_Missense_Mutation_p.D333G	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	333	ANK 6.				intracellular signal transduction					skin(2)|lung(1)	3						AATGGTTTTGATGTCAACACT	0.418													G	123269046	G	G	123269046	3	3	130	1	0	0	0	0	1	0	0	0	1019	333	12	4	1024	4	ASB15	7	123269046	Missense_Mutation	SNP	A	TCGA-14-0789-01A-01W-0424-08	23699420	123269046	35869617	44	8915											
ALDH1A1	216	broad.mit.edu	37	chr9	75567900	75567900	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtaggacaggtaagtctggcGtgcctgaggatgacatttct	14	7	2	2	rs144704960		TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr9:75567900G>A	uc004ajd.2	-	1	70	c.17C>T	c.(16-18)ACG>ATG	p.T6M	ALDH1A1_uc011lsh.1_Intron	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	6					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TAAGTCTGGCGTGCCTGAGGA	0.418													A	75567900	A	A	75567900	3	1	130	1	0	0	0	0	1	0	0	0	490	1145	40	1	1540	1	ALDH1A1	9	75567900	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08		75567900	65645531	45	8916											
OLFML2A	169611	broad.mit.edu	37	chr9	127566377	127566377	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcttctctctgcagacaaCaccctccagggcacttcctg	8	16	3	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr9:127566377C>T	uc004bov.2	+	6	1037	c.924C>T	c.(922-924)AAC>AAT	p.N308N	OLFML2A_uc010mwr.1_Silent_p.N272N|OLFML2A_uc004bow.2_Silent_p.N94N	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	308											0						CTGCAGACAACACCCTCCAGG	0.637													T	127566377	T	T	127566377	2	4	130	1	0	0	0	0	0	0	0	1	10857	477	17	3		3	OLFML2A	9	127566377	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	51998477	127566377	13647054	46	8917											
DBH	1621	broad.mit.edu	37	chr9	136507481	136507481	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgccctcagacgcgtgcacCatggaggtccaagctcccaa	10	15	1	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr9:136507481C>T	uc004cel.2	+	3	648	c.639C>T	c.(637-639)ACC>ACT	p.T213T		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	213	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	ACGCGTGCACCATGGAGGTCC	0.592													T	136507481	T	T	136507481	2	4	130	1	0	0	0	0	0	0	0	1	4250	581	21	3		3	DBH	9	136507481	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	8941104	136507481	4705950	47	8918											
OR52D1	390066	broad.mit.edu	37	chr11	5510222	5510222	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggctccatgctggtgagattTcctttggtggatgcctggcc	14	10	0	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr11:5510222T>A	uc010qzg.1	+	1	286	c.286T>A	c.(286-288)TCC>ACC	p.S96T	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGTGAGATTTCCTTTGGTGG	0.498													A	5510222	A	A	5510222	3	1	130	1	0	0	0	0	1	0	0	0	11114	1783	62	5	288	5	OR52D1	11	5510222	Missense_Mutation	SNP	T	TCGA-14-0789-01A-01W-0424-08		5510222	129496294	48	8919											
PRMT3	10196	broad.mit.edu	37	chr11	20448405	20448405	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagatgttatcatatctgaGtggatggtgagtgtttatag	13	2	2	3			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr11:20448405G>A	uc001mqb.2	+	10	1204	c.987G>A	c.(985-987)GAG>GAA	p.E329E	PRMT3_uc001mqc.2_Silent_p.E252E|PRMT3_uc010rdn.1_Silent_p.E267E	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	329							zinc ion binding				0						TCATATCTGAGTGGATGGTGA	0.254													A	20448405	A	A	20448405	2	1	130	1	0	0	0	0	0	0	0	1	12538	1020	36	3		3	PRMT3	11	20448405	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08	14938183	20448405	114558111	49	8920											
TMPRSS4	56649	broad.mit.edu	37	chr11	117985881	117985881	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgacatactgctgcaggcGtcagtccaggtcattgacag	11	11	3	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr11:117985881G>A	uc010rxo.1	+	11	1329	c.1038G>A	c.(1036-1038)GCG>GCA	p.A346A	TMPRSS4_uc010rxp.1_Silent_p.A341A|TMPRSS4_uc010rxq.1_Silent_p.A199A|TMPRSS4_uc010rxr.1_Silent_p.A321A|TMPRSS4_uc010rxs.1_Silent_p.A306A|TMPRSS4_uc009yzu.2_Intron|TMPRSS4_uc010rxt.1_Silent_p.A321A	NM_019894	NP_063947	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4 isoform 1	346	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		TGCTGCAGGCGTCAGTCCAGG	0.552													A	117985881	A	A	117985881	2	1	130	1	0	0	0	0	0	0	0	1	16246	1132	40	1		1	TMPRSS4	11	117985881	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08	97537476	117985881	17020635	50	8921											
TECTA	7007	broad.mit.edu	37	chr11	120998873	120998873	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctttgacggcgcctcctaCgccttcccctccgagttctc	7	19	1	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr11:120998873C>T	uc010rzo.1	+	8	2187	c.2187C>T	c.(2185-2187)TAC>TAT	p.Y729Y		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	729	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCGCCTCCTACGCCTTCCCCT	0.622													T	120998873	T	T	120998873	2	4	130	1	0	0	0	0	0	0	0	1	15744	547	19	1		1	TECTA	11	120998873	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	3012992	120998873	14007643	51	8922											
C12orf77	196415	broad.mit.edu	37	chr12	25148921	25148921	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caggagttgcaggcatccatCgtatgctgtccagcgtctgc	12	12	1	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr12:25148921C>T	uc001rgf.2	-	3	432	c.227G>A	c.(226-228)CGA>CAA	p.R76Q		NM_001101339	NP_001094809	C9JDV5	CL097_HUMAN	hypothetical protein LOC196415	76											0						AGGCATCCATCGTATGCTGTC	0.502													T	25148921	T	T	25148921	3	4	130	1	0	0	0	0	1	0	0	0	1716	884	31	2	218	2	C12orf77	12	25148921	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08		25148921	108702974	52	8923											
ACVRL1	94	broad.mit.edu	37	chr12	52309923	52309923	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cccgaggtgctggacgagcaGatccgcacggactgctttga	14	12	0	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr12:52309923G>A	uc001rzj.2	+	8	1435	c.1152G>A	c.(1150-1152)CAG>CAA	p.Q384Q	ACVRL1_uc001rzk.2_Silent_p.Q384Q|ACVRL1_uc010snm.1_Silent_p.Q210Q	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	384	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	TGGACGAGCAGATCCGCACGG	0.602									Hereditary_Hemorrhagic_Telangiectasia				A	52309923	A	A	52309923	2	1	130	1	0	0	0	0	0	0	0	1	225	933	33	3		3	ACVRL1	12	52309923	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08	27161002	52309923	81541972	53	8924											
ESPL1	9700	broad.mit.edu	37	chr12	53687195	53687195	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaccaggcccgccaagctccCcgactcaagtatcttattgg	8	15	2	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr12:53687195C>T	uc001sck.2	+	31	6391	c.6300C>T	c.(6298-6300)CCC>CCT	p.P2100P	ESPL1_uc001scj.2_Silent_p.P1775P|PFDN5_uc001scl.2_5'Flank|PFDN5_uc001scm.2_5'Flank|PFDN5_uc001scn.2_5'Flank|PFDN5_uc001sco.2_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	2100					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GCCAAGCTCCCCGACTCAAGT	0.567													T	53687195	T	T	53687195	2	4	130	1	0	0	0	0	0	0	0	1	5253	610	22	3		3	ESPL1	12	53687195	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	1377272	53687195	80164700	54	8925											
SRRM4	84530	broad.mit.edu	37	chr12	119568488	119568488	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcccccatccccaggcaccGcggccggtcccctgaggaag	11	20	0	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr12:119568488G>A	uc001txa.1	+	8	912	c.620G>A	c.(619-621)CGC>CAC	p.R207H		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	207	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding	p.R207H(1)		ovary(2)	2						CCCAGGCACCGCGGCCGGTCC	0.622													A	119568488	A	A	119568488	3	1	130	1	0	0	0	0	1	0	0	0	15170	1087	38	1	650	1	SRRM4	12	119568488	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	65881293	119568488	14283407	55	8926											
CIT	11113	broad.mit.edu	37	chr12	120138625	120138625	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaagaatccacgaacactcCaaattctgcaaggtgtcaag	8	10	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr12:120138625C>T	uc001txi.1	-	43	5475	c.5422G>A	c.(5422-5424)GGA>AGA	p.G1808R	CIT_uc001txh.1_Missense_Mutation_p.G1327R|CIT_uc001txj.1_Missense_Mutation_p.G1850R	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1808	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		ACGAACACTCCAAATTCTGCA	0.547													T	120138625	T	T	120138625	3	4	130	1	0	0	0	0	1	0	0	0	3438	603	21	3	681	3	CIT	12	120138625	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	570137	120138625	13713270	56	8927											
PAN3	255967	broad.mit.edu	37	chr13	28794510	28794510	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgctactgctggattagCgccaggtaagttgagtaact	11	10	0	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr13:28794510C>T	uc001urz.2	+	5	565	c.557C>T	c.(556-558)GCG>GTG	p.A186V	PAN3_uc010tdo.1_Missense_Mutation_p.A332V|PAN3_uc001ury.2_5'UTR|PAN3_uc001urx.2_Missense_Mutation_p.A132V	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	332	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		GCTGGATTAGCGCCAGGTAAG	0.423													T	28794510	T	T	28794510	3	4	130	1	0	0	0	0	1	0	0	0	11415	768	27	1	1017	1	PAN3	13	28794510	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08		28794510	86375368	57	8928											
TRIP11	9321	broad.mit.edu	37	chr14	92470681	92470681	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctttacttgctgttttaaCttgtcacgttcctgtagaag	7	8	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr14:92470681C>T	uc001xzy.2	-	11	4427	c.3639G>A	c.(3637-3639)AAG>AAA	p.K1213K	TRIP11_uc010auf.1_Silent_p.K949K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1213	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity	p.K1213N(1)		ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		GCTGTTTTAACTTGTCACGTT	0.428			T	PDGFRB	AML								T	92470681	T	T	92470681	2	4	130	1	0	0	0	0	0	0	0	1	16552	564	20	3		3	TRIP11	14	92470681	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08		92470681	14878859	58	8929											
PRIMA1	145270	broad.mit.edu	37	chr14	94203651	94203651	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccagggaggcacagcataCggcaatgatgatcaccagcc	11	13	1	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr14:94203651C>T	uc001ybw.1	-	4	337	c.295G>A	c.(295-297)GTA>ATA	p.V99I	PRIMA1_uc001ybx.1_RNA	NM_178013	NP_821092	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1 precursor	99	Helical; (Potential).				neurotransmitter catabolic process	cell junction|integral to membrane|synapse				large_intestine(1)|skin(1)	2		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		GCACAGCATACGGCAATGATG	0.532													T	94203651	T	T	94203651	3	4	130	1	0	0	0	0	1	0	0	0	12492	536	19	1	174	1	PRIMA1	14	94203651	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	1732970	94203651	13145889	59	8930											
AKT1	207	broad.mit.edu	37	chr14	105241276	105241276	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catctgggctcccactcactGtgaggaaggggtgcctggag	15	11	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr14:105241276G>A	uc001ypk.2	-	7	1186	c.632C>T	c.(631-633)ACA>ATA	p.T211I	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Missense_Mutation_p.T211I|AKT1_uc010axa.2_Missense_Mutation_p.T211I|AKT1_uc001ypm.2_Missense_Mutation_p.T211I|AKT1_uc001ypn.2_Missense_Mutation_p.T211I|AKT1_uc010tyk.1_Missense_Mutation_p.T149I	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	211	Protein kinase.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	CCCACTCACTGTGAGGAAGGG	0.647		1	Mis		breast|colorectal|ovarian|NSCLC								A	105241276	A	A	105241276	3	1	130	1	0	0	0	0	1	0	0	0	478	1391	48	3	842	3	AKT1	14	105241276	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	11037625	105241276	2108264	60	8931											
GABRB3	2562	broad.mit.edu	37	chr15	26793162	26793162	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	atgctctgtttcctgtactgGattcctgagttgtcaaagga	10	8	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr15:26793162G>T	uc001zaz.2	-	9	1342	c.1200C>A	c.(1198-1200)ATC>ATA	p.I400I	GABRB3_uc010uae.1_Silent_p.I315I|GABRB3_uc001zba.2_Silent_p.I400I|GABRB3_uc001zbb.2_Silent_p.I456I	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	400	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCCTGTACTGGATTCCTGAGT	0.512													T	26793162	T	T	26793162	2	4	130	1	0	0	0	0	0	0	0	1	6168	1164	41	5		5	GABRB3	15	26793162	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08		26793162	75738230	61	8932											
OTUD7A	161725	broad.mit.edu	37	chr15	31776752	31776752	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttggccacggagtcggcgCgcgtcttgtccttctccttg	13	13	2	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr15:31776752C>T	uc001zfq.2	-	11	1619	c.1526G>A	c.(1525-1527)CGC>CAC	p.R509H	OTUD7A_uc001zfr.2_Missense_Mutation_p.R516H	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	509	Nuclear localization signal (Potential).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GGAGTCGGCGCGCGTcttgtc	0.483													T	31776752	T	T	31776752	3	4	130	1	0	0	0	0	1	0	0	0	11318	768	27	1	1258	1	OTUD7A	15	31776752	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	4983590	31776752	70754640	62	8933											
RYR3	6263	broad.mit.edu	37	chr15	33765674	33765674	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttcataaggagcagaggaagTtctgcctggcagccgaggga	15	8	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr15:33765674T>A	uc001zhi.2	+	2	176	c.106T>A	c.(106-108)TTC>ATC	p.F36I	RYR3_uc010bar.2_Missense_Mutation_p.F36I	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	36	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCAGAGGAAGTTCTGCCTGGC	0.547													A	33765674	A	A	33765674	3	1	130	1	0	0	0	0	1	0	0	0	13770	1725	60	5	112	5	RYR3	15	33765674	Missense_Mutation	SNP	T	TCGA-14-0789-01A-01W-0424-08	1988922	33765674	68765718	63	8934											
DUOX2	50506	broad.mit.edu	37	chr15	45386398	45386398	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctcggtcctgcctgttgaCgagctgacaggccttctcta	12	13	1	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr15:45386398C>T	uc010bea.2	-	34	4800	c.4597G>A	c.(4597-4599)GTC>ATC	p.V1533I	DUOX2_uc001zun.2_Missense_Mutation_p.V1533I	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1533	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TGCCTGTTGACGAGCTGACAG	0.572													T	45386398	T	T	45386398	3	4	130	1	0	0	0	0	1	0	0	0	4801	536	19	1	53	1	DUOX2	15	45386398	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	11620724	45386398	57144994	64	8935											
CACNA1H	8912	broad.mit.edu	37	chr16	1262094	1262094	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggcggaggaggcgcggcGgcgagaggagaagcggctgc	24	8	0	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr16:1262094G>A	uc002cks.2	+	25	4963	c.4715G>A	c.(4714-4716)CGG>CAG	p.R1572Q	CACNA1H_uc002ckt.2_Missense_Mutation_p.R1572Q|CACNA1H_uc002cku.2_Missense_Mutation_p.R278Q|CACNA1H_uc010brj.2_Missense_Mutation_p.R278Q|CACNA1H_uc002ckv.2_Missense_Mutation_p.R278Q	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1572	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GAGGCGCGGCGGCGAGAGGAG	0.682													A	1262094	A	A	1262094	3	1	130	1	0	0	0	0	1	0	0	0	2545	1116	39	2	4809	2	CACNA1H	16	1262094	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08		1262094	89092659	65	8936											
PAQR4	124222	broad.mit.edu	37	chr16	3021625	3021625	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gccggctggcgtgctctcacCgccccctccaccagtgctcg	11	20	1	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr16:3021625C>A	uc002csj.3	+	3	832	c.498C>A	c.(496-498)ACC>ACA	p.T166T	PAQR4_uc002csk.3_Silent_p.T127T|PAQR4_uc002csl.3_Silent_p.T92T|PAQR4_uc010uwm.1_Silent_p.T97T	NM_152341	NP_689554	Q8N4S7	PAQR4_HUMAN	progestin and adipoQ receptor family member IV	166	Helical; (Potential).					integral to membrane	receptor activity				0						GTGCTCTCACCGCCCCCTCCA	0.697													A	3021625	A	A	3021625	2	1	130	1	0	0	0	0	0	0	0	1	11437	639	23	5		5	PAQR4	16	3021625	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	1759531	3021625	87333128	66	8937											
ZP2	7783	broad.mit.edu	37	chr16	21213466	21213466	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attcaggggtatgtggaaccGtaccagcccctgagactgag	13	10	1	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr16:21213466G>A	uc002dii.2	-	11	1246	c.1246C>T	c.(1246-1248)CGG>TGG	p.R416W	ZP2_uc010bwn.1_Missense_Mutation_p.R455W	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	416	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		ATGTGGAACCGTACCAGCCCC	0.507													A	21213466	A	A	21213466	3	1	130	1	0	0	0	0	1	0	0	0	18213	1144	40	1	1027	1	ZP2	16	21213466	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	18191841	21213466	69141287	67	8938											
NF1	4763	broad.mit.edu	37	chr17	29556481	29556481	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttttttgactcccaaggaCaggtaaagtgttctcttatt	8	7	1	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr17:29556481C>T	uc002hgg.2	+	21	3181	c.2848C>T	c.(2848-2850)CAG>TAG	p.Q950*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q950*|NF1_uc010csn.1_Nonsense_Mutation_p.Q810*|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	950					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTCCCAAGGACAGGTAAAGTG	0.348			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29556481	T	T	29556481	4	4	130	1	0	0	0	0	0	1	0	0	10356	479	17	3	2991	3	NF1	17	29556481	Nonsense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08		29556481	51638729	68	8939											
MARCH10	162333	broad.mit.edu	37	chr17	60865912	60865912	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcccccaaaactgatcgcGtttcttctcatttgggtctc	7	13	3	1	rs146312903	byFrequency	TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr17:60865912G>A	uc010ddr.2	-	3	377	c.139C>T	c.(139-141)CGC>TGC	p.R47C	MARCH10_uc002jag.3_Missense_Mutation_p.R47C|MARCH10_uc010dds.2_Missense_Mutation_p.R47C|MARCH10_uc002jah.2_Missense_Mutation_p.R47C	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	47							ligase activity|zinc ion binding				0						AACTGATCGCGTTTCTTCTCA	0.443													A	60865912	A	A	60865912	3	1	130	1	0	0	0	0	1	0	0	0	9299	1145	40	1	2323	1	MARCH10	17	60865912	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	31309431	60865912	20329298	69	8940											
POTEC	388468	broad.mit.edu	37	chr18	14542738	14542738	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcttgtccagatcttctcgAcggacgtggtacctcggctc	11	13	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr18:14542738A>G	uc010dln.2	-	1	862	c.408T>C	c.(406-408)CGT>CGC	p.R136R	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	136										skin(3)	3						GATCTTCTCGACGGACGTGGT	0.607													G	14542738	G	G	14542738	2	3	130	1	0	0	0	0	0	0	0	1	12262	262	10	4		4	POTEC	18	14542738	Silent	SNP	A	TCGA-14-0789-01A-01W-0424-08		14542738	63534510	70	8941											
ZNF532	55205	broad.mit.edu	37	chr18	56587754	56587754	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccatgcccctagatgaagaCccctccaaactgtgtagaca	8	14	0	4			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr18:56587754C>T	uc002lho.2	+	4	2782	c.2235C>T	c.(2233-2235)GAC>GAT	p.D745D	ZNF532_uc002lhp.2_Silent_p.D743D|ZNF532_uc010xeg.1_Silent_p.D743D|ZNF532_uc002lhr.2_Silent_p.D743D|ZNF532_uc002lhs.2_Silent_p.D743D	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	745					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TAGATGAAGACCCCTCCAAAC	0.483													T	56587754	T	T	56587754	2	4	130	1	0	0	0	0	0	0	0	1	17969	506	18	3		3	ZNF532	18	56587754	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	42045016	56587754	21489494	71	8942											
ZNF516	9658	broad.mit.edu	37	chr18	74154336	74154336	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgctgccgggcccctgcgcGgtgatgtggtccctctcgat	14	16	1	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr18:74154336G>A	uc010dqx.1	-	2	910	c.675C>T	c.(673-675)ACC>ACT	p.T225T	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GCCCCTGCGCGGTGATGTGGT	0.697													A	74154336	A	A	74154336	2	1	130	1	0	0	0	0	0	0	0	1	17957	1103	39	2		2	ZNF516	18	74154336	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08	17566582	74154336	3922912	72	8943											
ACTL9	284382	broad.mit.edu	37	chr19	8807821	8807821	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagtagcatttgcggtacaCgatatagggaccctgttcct	10	10	1	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr19:8807821C>T	uc002mkl.2	-	1	1352	c.1231G>A	c.(1231-1233)GTG>ATG	p.V411M		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	411						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						TTGCGGTACACGATATAGGGA	0.632													T	8807821	T	T	8807821	3	4	130	1	0	0	0	0	1	0	0	0	203	536	19	1	23	1	ACTL9	19	8807821	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08		8807821	50321162	73	8944											
LDLR	3949	broad.mit.edu	37	chr19	11224366	11224366	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctctgttgcggataccaaggGcgtgaagaggaaaacgttat	13	7	1	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr19:11224366G>C	uc002mqk.3	+	10	1682	c.1514G>C	c.(1513-1515)GGC>GCC	p.G505A	LDLR_uc010xlk.1_Missense_Mutation_p.G505A|LDLR_uc010xll.1_Missense_Mutation_p.G464A|LDLR_uc010xlm.1_Missense_Mutation_p.G358A|LDLR_uc010xln.1_Missense_Mutation_p.G378A|LDLR_uc010xlo.1_Missense_Mutation_p.G337A	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	505	Extracellular (Potential).|LDL-receptor class B 3.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GATACCAAGGGCGTGAAGAGG	0.592													C	11224366	C	C	11224366	3	2	130	1	0	0	0	0	1	0	0	0	8704	1203	42	5	1552	5	LDLR	19	11224366	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	2416545	11224366	47904617	74	8945											
ZNF709	163051	broad.mit.edu	37	chr19	12575498	12575498	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggtttctctccagtgtgaGttctttcatgcattcgaaag	11	8	3	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr19:12575498G>A	uc002mtv.3	-	4	1399	c.1238C>T	c.(1237-1239)ACT>ATT	p.T413I	ZNF709_uc002mtw.3_Missense_Mutation_p.T381I|ZNF709_uc002mtx.3_Missense_Mutation_p.T413I	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	413	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCAGTGTGAGTTCTTTCATG	0.418													A	12575498	A	A	12575498	3	1	130	1	0	0	0	0	1	0	0	0	18110	1029	36	3	691	3	ZNF709	19	12575498	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	1351132	12575498	46553485	75	8946											
GIPC1	10755	broad.mit.edu	37	chr19	14591540	14591540	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tccagcccgatctggcccccCaggagcttgtccatgtccac	9	18	1	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr19:14591540C>G	uc002myt.2	-	5	609	c.339G>C	c.(337-339)CTG>CTC	p.L113L	GIPC1_uc002myu.2_Silent_p.L113L|GIPC1_uc002myv.2_Silent_p.L16L|GIPC1_uc002myw.2_Silent_p.L16L|GIPC1_uc002myx.2_Silent_p.L113L|GIPC1_uc002myy.2_Silent_p.L16L	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	113					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						TCTGGCCCCCCAGGAGCTTGT	0.612											OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	14591540	G	G	14591540	2	3	130	1	0	0	0	0	0	0	0	1	6392	581	21	5		5	GIPC1	19	14591540	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08	2016042	14591540	44537443	76	8947											
ZNF546	339327	broad.mit.edu	37	chr19	40521654	40521656	+	In_Frame_Del	DEL	ATC	-	-													acttactttacatcagagaaAtcatattagtgaggaagtcc							TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr19:40521654_40521656delATC	uc002oms.2	+	7	2733_2735	c.2477_2479delATC	c.(2476-2481)AATCAT>AAT	p.H827del	ZNF546_uc002omt.2_In_Frame_Del_p.H801del	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	827	C2H2-type 22.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CATCAGAGAAATCATATTAGTGA	0.33													-	40521656	-	-	40521654	7	5	130	1	0	1	0	1	0	0	0	0	17975	101	4	0	2495	0	ZNF546	19	40521654	In_Frame_Del	DEL	ATC	TCGA-14-0789-01A-01W-0424-08	25930114	40521654	18607329	77	8948											
TSKS	60385	broad.mit.edu	37	chr19	50243159	50243159	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagggagcacatcttcaaGtgtagatggtccagagtggc	15	7	2	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr19:50243159G>A	uc002ppm.2	-	11	1664	c.1653C>T	c.(1651-1653)CAC>CAT	p.H551H		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	551							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		ACATCTTCAAGTGTAGATGGT	0.592													A	50243159	A	A	50243159	2	1	130	1	0	0	0	0	0	0	0	1	16623	1020	36	3		3	TSKS	19	50243159	Silent	SNP	G	TCGA-14-0789-01A-01W-0424-08	9721505	50243159	8885824	78	8949											
FCAR	2204	broad.mit.edu	37	chr19	55385635	55385635	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagatgtggaaattccctgaCgaggggctctgtcctcatac	11	10	2	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr19:55385635C>T	uc002qhr.1	+	1	87	c.-110C>T	c.(-112--108)GACGA>GATGA		FCAR_uc002qhq.2_Translation_Start_Site|FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Translation_Start_Site|FCAR_uc010esi.1_Translation_Start_Site|FCAR_uc002qhu.1_Translation_Start_Site|FCAR_uc002qhv.1_Translation_Start_Site|FCAR_uc002qhw.1_Translation_Start_Site|FCAR_uc002qhx.1_Translation_Start_Site|FCAR_uc002qhy.1_Translation_Start_Site|FCAR_uc002qhz.1_Translation_Start_Site|FCAR_uc002qia.1_Translation_Start_Site	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor						immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		AATTCCCTGACGAGGGGCTCT	0.498													T	55385635	T	T	55385635	1	4	130	1	0	0	0	0	0	0	0	0	5773	551	19	1		1	FCAR	19	55385635	Translation_Start_Site	SNP	C	TCGA-14-0789-01A-01W-0424-08	5142476	55385635	3743348	79	8950											
PTPRA	5786	broad.mit.edu	37	chr20	2969091	2969091	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttaaccggagaatggcagacGacaataagctcttcagggag	12	8	2	2			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr20:2969091G>A	uc010zqd.1	+	8	1059	c.742G>A	c.(742-744)GAC>AAC	p.D248N	PTPRA_uc002whj.2_Missense_Mutation_p.D237N|PTPRA_uc010zqc.1_Missense_Mutation_p.D122N|PTPRA_uc002whk.2_Missense_Mutation_p.D228N|PTPRA_uc002whl.2_Missense_Mutation_p.D228N|PTPRA_uc002whm.2_Missense_Mutation_p.D4N|PTPRA_uc002whn.2_Missense_Mutation_p.D228N|PTPRA_uc002who.2_5'UTR	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	237	Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						AATGGCAGACGACAATAAGCT	0.507													A	2969091	A	A	2969091	3	1	130	1	0	0	0	0	1	0	0	0	12795	1058	37	2	731	2	PTPRA	20	2969091	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08		2969091	60056429	80	8951											
RBPJL	11317	broad.mit.edu	37	chr20	43936814	43936814	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctcccaatcctttgactcaCctgagcctgcaggacagatc	7	16	1	3			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr20:43936814C>A	uc002xns.2	+	2	126	c.54C>A	c.(52-54)CAC>CAA	p.H18Q	MATN4_uc002xnn.2_Intron|MATN4_uc002xno.2_Intron|MATN4_uc002xnp.2_Intron|MATN4_uc010zwr.1_5'Flank|MATN4_uc002xnr.1_Splice_Site|RBPJL_uc002xnt.2_Missense_Mutation_p.H18Q	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	18					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CTTTGACTCACCTGAGCCTGC	0.627													A	43936814	A	A	43936814	3	1	130	1	0	0	0	0	1	0	0	0	13162	521	18	5	60	5	RBPJL	20	43936814	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	40967723	43936814	19088706	81	8952											
NCOA5	57727	broad.mit.edu	37	chr20	44698964	44698964	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagtctctaagatccctcaCgtcccgaacgtcgcgcacac	7	16	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chr20:44698964C>T	uc002xrd.2	-	2	778	c.250G>A	c.(250-252)GTG>ATG	p.V84M	NCOA5_uc002xrc.2_Translation_Start_Site|NCOA5_uc002xre.2_Missense_Mutation_p.V84M	NM_020967	NP_066018	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	84	Arg/Asp-rich (mixed charge).|Transcription repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				AGATCCCTCACGTCCCGAACG	0.532													T	44698964	T	T	44698964	3	4	130	1	0	0	0	0	1	0	0	0	10232	536	19	1	1513	1	NCOA5	20	44698964	Missense_Mutation	SNP	C	TCGA-14-0789-01A-01W-0424-08	762150	44698964	18326556	82	8953											
TLR7	51284	broad.mit.edu	37	chrX	12904281	12904281	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagataacaatgtcacagcCgtccctactgttttgccatc	6	12	1	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chrX:12904281C>T	uc004cvc.2	+	3	793	c.654C>T	c.(652-654)GCC>GCT	p.A218A		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	218	Extracellular (Potential).|LRR 7.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ATGTCACAGCCGTCCCTACTG	0.343													T	12904281	T	T	12904281	2	4	130	1	0	0	0	0	0	0	0	1	15953	639	23	2		2	TLR7	23	12904281	Silent	SNP	C	TCGA-14-0789-01A-01W-0424-08		12904281	142366279	83	8954											
ZRSR2	8233	broad.mit.edu	37	chrX	15840971	15840971	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catctacttgtctccagatcGgactggctcctcctttggga	9	13	2	1			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chrX:15840971G>A	uc004cxg.3	+	11	1100	c.1055G>A	c.(1054-1056)CGG>CAG	p.R352Q		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	352					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					TCTCCAGATCGGACTGGCTCC	0.502													A	15840971	A	A	15840971	3	1	130	1	0	0	0	0	1	0	0	0	18222	1116	39	2	1097	2	ZRSR2	23	15840971	Missense_Mutation	SNP	G	TCGA-14-0789-01A-01W-0424-08	2936690	15840971	139429589	84	8955											
POF1B	79983	broad.mit.edu	37	chrX	84634327	84634327	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcgctcatacactacattttTttctggaggctgctgggctt	9	10	2	0			TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chrX:84634327T>G	uc004eer.2	-	2	279	c.133A>C	c.(133-135)AAA>CAA	p.K45Q	POF1B_uc004ees.2_Missense_Mutation_p.K45Q	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	45							actin binding				0						ACTACATTTTTTTCTGGAGGC	0.577													G	84634327	G	G	84634327	3	3	130	1	0	0	0	0	1	0	0	0	12182	1850	64	5	1700	5	POF1B	23	84634327	Missense_Mutation	SNP	T	TCGA-14-0789-01A-01W-0424-08	68793356	84634327	70636233	85	8956											
THOC2	57187	broad.mit.edu	37	chrX	122748018	122748020	+	In_Frame_Del	DEL	GGA	-	-													ccttactcttggacagtggtGgaggagtatgattaatgtag							TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chrX:122748018_122748020delGGA	uc004etu.2	-	34	4364_4366	c.4332_4334delTCC	c.(4330-4335)CCTCCA>CCA	p.1444_1445PP>P	THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_In_Frame_Del_p.265_266PP>P	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1444_1445	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						GGACAGTGGTGGAGGAGTATGAT	0.355													-	122748020	-	-	122748018	7	5	130	1	0	1	0	1	0	0	0	0	15862	1348	47	0	467	0	THOC2	23	122748018	In_Frame_Del	DEL	GGA	TCGA-14-0789-01A-01W-0424-08	38113691	122748018	32522542	86	8957											
STAG2	10735	broad.mit.edu	37	chrX	123176470	123176471	+	Frame_Shift_Ins	INS	-	A	A													cagaactctgagataattcgINSaaaaatgactgaagaattcg							TCGA-14-0789-01A-01W-0424-08	TCGA-14-0789-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	3462087f-f791-43b4-b9d9-b11cc48eaf9e	221ae08d-6862-47d4-9b1d-099cb3dd9e57	g.chrX:123176470_123176471insA	uc004etz.3	+	6	776_777	c.437_438insA	c.(436-438)CGAfs	p.R146fs	STAG2_uc004eua.2_Frame_Shift_Ins_p.R146fs|STAG2_uc004eub.2_Frame_Shift_Ins_p.R146fs|STAG2_uc004euc.2_Frame_Shift_Ins_p.R146fs|STAG2_uc004eud.2_Frame_Shift_Ins_p.R146fs|STAG2_uc004eue.2_Frame_Shift_Ins_p.R146fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	146					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GAGATAATTCGAAAAATGACTG	0.287													A	123176471	A	A	123176470	7	5	130	1	0	1	1	0	0	0	0	0	15242	1058	37	0	455	0	STAG2	23	123176470	Frame_Shift_Ins	INS	-	TCGA-14-0789-01A-01W-0424-08	428452	123176470	32094090	87	8958											
ZCCHC17	51538	broad.mit.edu	37	chr1	31810124	31810125	+	Splice_Site	INS	-	A	A													aagcttattggccgagaggtINSaaagttctgtgcggctccct							TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr1:31810124_31810125insA	uc001bsp.1	+	4	361	c.225_splice	c.e4+2	p.E75_splice	ZCCHC17_uc001bsq.1_Splice_Site_p.E67_splice|ZCCHC17_uc010ogf.1_Splice_Site_p.E51_splice|ZCCHC17_uc009vtu.1_Splice_Site_p.E51_splice|ZCCHC17_uc001bsr.1_Splice_Site_p.E75_splice|ZCCHC17_uc009vtv.1_Splice_Site_p.E51_splice	NM_016505	NP_057589	Q9NP64	NO40_HUMAN	zinc finger, CCHC domain containing 17							nucleolus	RNA binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|all_neural(195;0.146)|Medulloblastoma(700;0.151)|Breast(348;0.222)		STAD - Stomach adenocarcinoma(196;0.0215)|READ - Rectum adenocarcinoma(331;0.168)		GGCCGAGAGGTAAAGTTCTGTG	0.426													A	31810125	A	A	31810124	8	5	131	1	0	1	1	0	0	0	1	0	17582	1652	57	0	237	0	ZCCHC17	1	31810124	Splice_Site	INS	-	TCGA-14-0790-01B-01D-1494-08		31810124	217440497	1	8959											
RPL5	6125	broad.mit.edu	37	chr1	93300358	93300358	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcttatgcccgtatagaggGggatatgatagtctgcgcag	14	7	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr1:93300358G>A	uc001doz.2	+	4	290	c.212G>A	c.(211-213)GGG>GAG	p.G71E	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_RNA|RPL5_uc001dpb.2_Missense_Mutation_p.G21E|RPL5_uc001dpd.2_5'Flank|SNORD21_uc001dpe.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5	71					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		CGTATAGAGGGGGATATGATA	0.413													A	93300358	A	A	93300358	3	1	131	1	0	0	0	0	1	0	0	0	13597	1232	43	3	226	3	RPL5	1	93300358	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	61490234	93300358	155950263	2	8960											
BCAR3	8412	broad.mit.edu	37	chr1	94032953	94032953	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtcgtttttttcccacatgtCggttccttcaaaagtcacag	7	11	2	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr1:94032953C>T	uc001dpz.2	-	11	2457	c.2182G>A	c.(2182-2184)GAC>AAC	p.D728N	BCAR3_uc001dqa.2_Missense_Mutation_p.D728N|BCAR3_uc001dqb.2_Missense_Mutation_p.D728N|BCAR3_uc001dpx.3_Missense_Mutation_p.D404N|BCAR3_uc001dpy.2_Missense_Mutation_p.D637N	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	728	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		TCCCACATGTCGGTTCCTTCA	0.512													T	94032953	T	T	94032953	3	4	131	1	0	0	0	0	1	0	0	0	1349	884	31	2	303	2	BCAR3	1	94032953	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	732595	94032953	155217668	3	8961											
S1PR1	1901	broad.mit.edu	37	chr1	101705315	101705317	+	In_Frame_Del	DEL	ATT	-	-													tggcgctgctcaagaccgtaAttatcgtcctgagcgtcttc							TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr1:101705315_101705317delATT	uc001dud.2	+	2	1289_1291	c.775_777delATT	c.(775-777)ATTdel	p.I260del	S1PR1_uc009weg.2_In_Frame_Del_p.I260del	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	260	Helical; Name=6; (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						CAAGACCGTAATTATCGTCCTGA	0.591													-	101705317	-	-	101705315	7	5	131	1	0	1	0	1	0	0	0	0	13793	101	4	0	777	0	S1PR1	1	101705315	In_Frame_Del	DEL	ATT	TCGA-14-0790-01B-01D-1494-08	7672362	101705315	147545306	4	8962											
CD58	965	broad.mit.edu	37	chr1	117078713	117078713	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atatatactggttgagttacGtttacattgctccataggac	8	7	0	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr1:117078713G>A	uc001egm.2	-	3	623	c.502C>T	c.(502-504)CGT>TGT	p.R168C	CD58_uc001egn.2_RNA|CD58_uc010owy.1_Missense_Mutation_p.R168C|CD58_uc001ego.1_Intron|CD58_uc001egp.3_Missense_Mutation_p.R168C	NM_001779	NP_001770	P19256	LFA3_HUMAN	CD58 molecule isoform 1	168	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding				0	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		GTTGAGTTACGTTTACATTGC	0.343													A	117078713	A	A	117078713	3	1	131	1	0	0	0	0	1	0	0	0	3025	1145	40	1	270	1	CD58	1	117078713	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	15373398	117078713	132171908	5	8963											
SPAG17	200162	broad.mit.edu	37	chr1	118623774	118623774	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgatgctctcctgctctaacAgctgtctattatcagggact	8	11	4	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr1:118623774A>T	uc001ehk.2	-	15	2227	c.2159T>A	c.(2158-2160)CTG>CAG	p.L720Q		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	720						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTGCTCTAACAGCTGTCTATT	0.363													T	118623774	T	T	118623774	3	4	131	1	0	0	0	0	1	0	0	0	14979	188	7	5	4648	5	SPAG17	1	118623774	Missense_Mutation	SNP	A	TCGA-14-0790-01B-01D-1494-08	1545061	118623774	130626847	6	8964											
SPAG17	200162	broad.mit.edu	37	chr1	118628591	118628591	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaattgtagctagacgtttAgtgttgttccatggtggggg	15	4	0	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr1:118628591A>C	uc001ehk.2	-	13	1784	c.1716T>G	c.(1714-1716)ACT>ACG	p.T572T		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	572						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTAGACGTTTAGTGTTGTTCC	0.388													C	118628591	C	C	118628591	2	2	131	1	0	0	0	0	0	0	0	1	14979	407	15	5		5	SPAG17	1	118628591	Silent	SNP	A	TCGA-14-0790-01B-01D-1494-08	4817	118628591	130622030	7	8965											
SPTA1	6708	broad.mit.edu	37	chr1	158655079	158655079	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accgagtcaacacttcctgaCgcctctcctggatctcttct	6	16	4	1	rs121918641		TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr1:158655079C>T	uc001fst.1	-	2	282	c.83G>A	c.(82-84)CGT>CAT	p.R28H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	28	Spectrin 1.		R -> C (in EL2).|R -> L (in EL2).		actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CACTTCCTGACGCCTCTCCTG	0.348													T	158655079	T	T	158655079	3	4	131	1	0	0	0	0	1	0	0	0	15115	536	19	1	7380	1	SPTA1	1	158655079	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	40026488	158655079	90595542	8	8966											
LEFTY2	7044	broad.mit.edu	37	chr1	226127121	226127121	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccccaagcccggctggcGccccctgcgaggcaaagcgg	14	18	0	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr1:226127121G>A	uc001hpt.1	-	3	757	c.677C>T	c.(676-678)GCG>GTG	p.A226V	LEFTY2_uc010pvk.1_Missense_Mutation_p.A192V|LEFTY2_uc009xek.1_Intron	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor	226					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					CCCGGCTGGCGCCCCCTGCGA	0.701													A	226127121	A	A	226127121	3	1	131	1	0	0	0	0	1	0	0	0	8716	1087	38	1	431	1	LEFTY2	1	226127121	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	67472042	226127121	23123500	9	8967											
KIDINS220	57498	broad.mit.edu	37	chr2	8943255	8943255	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaataagtgcagtcattgaAttctaaaaacaacaacaaca	4	8	2	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr2:8943255A>G	uc002qzc.2	-	8	788	c.606T>C	c.(604-606)AAT>AAC	p.N202N	KIDINS220_uc010yiv.1_Silent_p.N11N|KIDINS220_uc002qzd.2_Silent_p.N160N|KIDINS220_uc010yiw.1_Silent_p.N203N	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	202	ANK 7.|Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CAGTCATTGAATTCTAAAAAC	0.299													G	8943255	G	G	8943255	2	3	131	1	0	0	0	0	0	0	0	1	8271	98	4	4		4	KIDINS220	2	8943255	Silent	SNP	A	TCGA-14-0790-01B-01D-1494-08		8943255	234256118	10	8968											
IL18RAP	8807	broad.mit.edu	37	chr2	103068411	103068411	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccaagagccagagtctctaCctcatctcgtgaaaaaagct	7	12	3	3			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr2:103068411C>T	uc002tbx.2	+	12	2054	c.1570C>T	c.(1570-1572)CCT>TCT	p.P524S	IL18RAP_uc010fiz.2_Missense_Mutation_p.P382S	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	524	TIR.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						AGAGTCTCTACCTCATCTCGT	0.418													T	103068411	T	T	103068411	3	4	131	1	0	0	0	0	1	0	0	0	7648	507	18	3	1608	3	IL18RAP	2	103068411	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	94125156	103068411	140130962	11	8969											
LIMS1	3987	broad.mit.edu	37	chr2	109292448	109292448	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgacggcccatcgaagggcgCgtggtgaacgctatgggcaa	16	11	0	1	rs111779374		TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr2:109292448C>T	uc002teg.2	+	6	728	c.609C>T	c.(607-609)CGC>CGT	p.R203R	LIMS1_uc002tef.2_Silent_p.R215R|LIMS1_uc002teh.2_Silent_p.R203R|LIMS1_uc002tei.2_Silent_p.R203R|LIMS1_uc002tej.2_Silent_p.R240R|LIMS1_uc002tek.3_Silent_p.R265R	NM_004987	NP_004978	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	203	LIM zinc-binding 4.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding				0						TCGAAGGGCGCGTGGTGAACG	0.537													T	109292448	T	T	109292448	2	4	131	1	0	0	0	0	0	0	0	1	8803	755	27	1		1	LIMS1	2	109292448	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	6224037	109292448	133906925	12	8970											
DPP10	57628	broad.mit.edu	37	chr2	116447456	116447456	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccagaagtagaggactccGtcttgcagtacgcggcctgg	13	12	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr2:116447456G>A	uc002tla.1	+	7	992	c.535G>A	c.(535-537)GTC>ATC	p.V179I	DPP10_uc002tlb.1_Missense_Mutation_p.V129I|DPP10_uc002tlc.1_Missense_Mutation_p.V175I|DPP10_uc002tle.2_Missense_Mutation_p.V183I|DPP10_uc002tlf.1_Missense_Mutation_p.V172I	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	179	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AGAGGACTCCGTCTTGCAGTA	0.438													A	116447456	A	A	116447456	3	1	131	1	0	0	0	0	1	0	0	0	4727	1145	40	1	732	1	DPP10	2	116447456	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	7155008	116447456	126751917	13	8971											
CYP8B1	1582	broad.mit.edu	37	chr3	42916850	42916850	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagactccagcctttggaCgtcagcattacaaaggacag	9	12	1	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr3:42916850C>T	uc003cmh.2	-	1	784	c.459G>A	c.(457-459)ACG>ACA	p.T153T	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Silent_p.T153T	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	153					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		AGCCTTTGGACGTCAGCATTA	0.512													T	42916850	T	T	42916850	2	4	131	1	0	0	0	0	0	0	0	1	4198	523	19	1		1	CYP8B1	3	42916850	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08		42916850	155105580	14	8972											
MYLK	4638	broad.mit.edu	37	chr3	123376130	123376130	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtggctagttccttccaCgtcttgttggctgagtccca	10	12	1	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr3:123376130C>T	uc003ego.2	-	24	4413	c.4131G>A	c.(4129-4131)ACG>ACA	p.T1377T	MYLK_uc010hrr.2_Translation_Start_Site|MYLK_uc011bjv.1_Silent_p.T177T|MYLK_uc011bjw.1_Silent_p.T1377T|MYLK_uc003egp.2_Silent_p.T1308T|MYLK_uc003egq.2_Silent_p.T1377T|MYLK_uc003egr.2_Silent_p.T1308T|MYLK_uc003egs.2_Silent_p.T1201T	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1377	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Fibronectin type-III.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GTTCCTTCCACGTCTTGTTGG	0.542													T	123376130	T	T	123376130	2	4	131	1	0	0	0	0	0	0	0	1	10056	523	19	1		1	MYLK	3	123376130	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	80459280	123376130	74646300	15	8973											
RTP1	132112	broad.mit.edu	37	chr3	186917604	186917604	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accgcatccacgtggccagcCgccaggacaaccggcggcac	12	18	0	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr3:186917604C>T	uc003frg.2	+	2	568	c.538C>T	c.(538-540)CGC>TGC	p.R180C		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	180	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		CGTGGCCAGCCGCCAGGACAA	0.682													T	186917604	T	T	186917604	3	4	131	1	0	0	0	0	1	0	0	0	13733	652	23	2	544	2	RTP1	3	186917604	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	63541474	186917604	11104826	16	8974											
HPSE	10855	broad.mit.edu	37	chr4	84223384	84223384	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgccattaacaccttggtgCccaccaatttcttgaacaga	6	12	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr4:84223384C>T	uc003hoj.3	-	10	1343	c.1244G>A	c.(1243-1245)GGC>GAC	p.G415D	HPSE_uc010ika.2_Missense_Mutation_p.G357D|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.G158D|HPSE_uc011cct.1_Missense_Mutation_p.G341D|HPSE_uc003hok.3_Missense_Mutation_p.G415D	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	415					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	CACCTTGGTGCCCACCAATTT	0.403													T	84223384	T	T	84223384	3	4	131	1	0	0	0	0	1	0	0	0	7344	739	26	3	399	3	HPSE	4	84223384	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08		84223384	106930892	17	8975											
ZFP42	132625	broad.mit.edu	37	chr4	188924752	188924752	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggactttaatttgcgtaCgcacgtgcgcatccacacgg	10	12	1	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr4:188924752C>T	uc003izg.1	+	3	1036	c.791C>T	c.(790-792)ACG>ATG	p.T264M	ZFP42_uc003izh.1_Missense_Mutation_p.T264M|ZFP42_uc003izi.1_Missense_Mutation_p.T264M	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	264	C2H2-type 3.				female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AATTTGCGTACGCACGTGCGC	0.483													T	188924752	T	T	188924752	3	4	131	1	0	0	0	0	1	0	0	0	17647	536	19	1	793	1	ZFP42	4	188924752	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	104701368	188924752	2229524	18	8976											
AHRR	57491	broad.mit.edu	37	chr5	422883	422883	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatttatgactacatccacGtggacgaccgccaggacttc	8	13	0	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr5:422883G>A	uc003jav.2	+	6	537	c.493G>A	c.(493-495)GTG>ATG	p.V165M	AHRR_uc003jaw.2_Missense_Mutation_p.V161M|AHRR_uc010isy.2_Missense_Mutation_p.V11M|AHRR_uc010isz.2_Missense_Mutation_p.V161M|AHRR_uc003jax.2_Translation_Start_Site|AHRR_uc003jay.2_Missense_Mutation_p.V21M	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	165	PAS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CTACATCCACGTGGACGACCG	0.547													A	422883	A	A	422883	3	1	131	1	0	0	0	0	1	0	0	0	417	1145	40	1	515	1	AHRR	5	422883	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08		422883	180492377	19	8977											
MAP3K1	4214	broad.mit.edu	37	chr5	56160697	56160697	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttactgcagcagatagggcCtaactctttcctgattggag	10	10	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr5:56160697C>T	uc003jqw.3	+	4	1472	c.971C>T	c.(970-972)CCT>CTT	p.P324L		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	324					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		CAGATAGGGCCTAACTCTTTC	0.468													T	56160697	T	T	56160697	3	4	131	1	0	0	0	0	1	0	0	0	9243	681	24	3	985	3	MAP3K1	5	56160697	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	55737814	56160697	124754563	20	8978											
PIK3R1	5295	broad.mit.edu	37	chr5	67576379	67576379	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tacaaagctccgaagaatatAttcagctattgaagaagctt	7	7	1	3			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr5:67576379A>T	uc003jva.2	+	6	1218	c.658A>T	c.(658-660)ATT>TTT	p.I220F	PIK3R1_uc003jvb.2_Missense_Mutation_p.I220F	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	220	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CGAAGAATATATTCAGCTATT	0.343			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			T	67576379	T	T	67576379	3	4	131	1	0	0	0	0	1	0	0	0	11918	449	16	5	676	5	PIK3R1	5	67576379	Missense_Mutation	SNP	A	TCGA-14-0790-01B-01D-1494-08	11415682	67576379	113338881	21	8979											
ZNF608	57507	broad.mit.edu	37	chr5	123984804	123984804	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gccccctctcatctccaggtCacttgtcggtgactcacaaa	7	16	4	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr5:123984804C>A	uc003ktq.1	-	4	1396	c.1273G>T	c.(1273-1275)GAC>TAC	p.D425Y	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.D425Y|ZNF608_uc003ktt.1_Missense_Mutation_p.D425Y	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	425						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ATCTCCAGGTCACTTGTCGGT	0.552													A	123984804	A	A	123984804	3	1	131	1	0	0	0	0	1	0	0	0	18031	826	29	5	3289	5	ZNF608	5	123984804	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	56408425	123984804	56930456	22	8980											
FBXO38	81545	broad.mit.edu	37	chr5	147781654	147781654	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaagagtaaggggccatgaGgcttttagcattccaggagt	14	7	0	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr5:147781654G>A	uc003lpf.1	+	4	492	c.372G>A	c.(370-372)GAG>GAA	p.E124E	FBXO38_uc003lpg.1_Silent_p.E124E|FBXO38_uc003lph.2_Silent_p.E124E	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	124						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGCCATGAGGCTTTTAGCA	0.448													A	147781654	A	A	147781654	2	1	131	1	0	0	0	0	0	0	0	1	5746	991	35	3		3	FBXO38	5	147781654	Silent	SNP	G	TCGA-14-0790-01B-01D-1494-08	23796850	147781654	33133606	23	8981											
NDUFAF4	29078	broad.mit.edu	37	chr6	97344693	97344693	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcagcttttcatctttaCgagcaatctctcctttaact	4	12	3	0	rs142963790		TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr6:97344693C>T	uc003pow.2	-	2	257	c.167G>A	c.(166-168)CGT>CAT	p.R56H	NDUFAF4_uc003pov.2_RNA	NM_014165	NP_054884	Q9P032	NDUF4_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	56					mitochondrial respiratory chain complex I assembly	mitochondrial membrane	calmodulin binding			ovary(1)	1						TTCATCTTTACGAGCAATCTC	0.333													T	97344693	T	T	97344693	3	4	131	1	0	0	0	0	1	0	0	0	10277	536	19	1	368	1	NDUFAF4	6	97344693	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08		97344693	73770374	24	8982											
GRM1	2911	broad.mit.edu	37	chr6	146755476	146755476	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtggtcagcaacttcagtacCgcgatcccggattttcacgc	10	13	3	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr6:146755476C>A	uc010khw.1	+	9	3599	c.3129C>A	c.(3127-3129)ACC>ACA	p.T1043T	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1043	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ACTTCAGTACCGCGATCCCGG	0.672													A	146755476	A	A	146755476	2	1	131	1	0	0	0	0	0	0	0	1	6796	639	23	5		5	GRM1	6	146755476	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	49410783	146755476	24359591	25	8983											
TIAM2	26230	broad.mit.edu	37	chr6	155566797	155566797	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctctttcctttattacgCggaccactttaaactgtaca	6	11	1	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr6:155566797C>T	uc003qqb.2	+	21	4857	c.3584C>T	c.(3583-3585)GCG>GTG	p.A1195V	TIAM2_uc003qqe.2_Missense_Mutation_p.A1195V|TIAM2_uc010kjj.2_Missense_Mutation_p.A728V|TIAM2_uc003qqf.2_Missense_Mutation_p.A571V|TIAM2_uc011efl.1_Missense_Mutation_p.A531V|TIAM2_uc003qqg.2_Missense_Mutation_p.A507V|TIAM2_uc003qqh.2_Missense_Mutation_p.A120V	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1195	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CTTTATTACGCGGACCACTTT	0.403													T	155566797	T	T	155566797	3	4	131	1	0	0	0	0	1	0	0	0	15888	768	27	1	3646	1	TIAM2	6	155566797	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	8811321	155566797	15548270	26	8984											
ZPBP	11055	broad.mit.edu	37	chr7	50097645	50097645	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttccacagtaggtttatattCgaggaaacatgtataaattc	7	6	0	0	rs148913753		TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr7:50097645C>T	uc003tou.2	-	4	497	c.427G>A	c.(427-429)GAA>AAA	p.E143K	ZPBP_uc011kci.1_Missense_Mutation_p.E69K|ZPBP_uc010kyw.2_Missense_Mutation_p.E142K	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	143					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					GGTTTATATTCGAGGAAACAT	0.328													T	50097645	T	T	50097645	3	4	131	1	0	0	0	0	1	0	0	0	18216	893	31	2	648	2	ZPBP	7	50097645	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08		50097645	109041018	27	8985											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	131	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	5124177	55221822	103916841	28	8986											
EPO	2056	broad.mit.edu	37	chr7	100319586	100319586	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggctgtgtgcatttcagaCgggctgtgctgaacactgca	14	10	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr7:100319586C>T	uc003uwi.2	+	3	342	c.161C>T	c.(160-162)ACG>ATG	p.T54M	EPO_uc011kkc.1_Missense_Mutation_p.T54M	NM_000799	NP_000790	P01588	EPO_HUMAN	erythropoietin precursor	54					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	GCATTTCAGACGGGCTGTGCT	0.532													T	100319586	T	T	100319586	3	4	131	1	0	0	0	0	1	0	0	0	5188	550	19	1	171	1	EPO	7	100319586	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	45097764	100319586	58819077	29	8987											
LAMB1	3912	broad.mit.edu	37	chr7	107575937	107575937	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggcgagcctgctcctcttGtttttccttgaactgggatt	11	10	1	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr7:107575937G>A	uc003vew.2	-	27	4446	c.4111C>T	c.(4111-4113)CAA>TAA	p.Q1371*	LAMB1_uc003vev.2_Nonsense_Mutation_p.Q1395*	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1371	Potential.|Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCTCCTCTTGTTTTTCCTTG	0.532													A	107575937	A	A	107575937	4	1	131	1	0	0	0	0	0	1	0	0	8610	1386	48	3	1281	3	LAMB1	7	107575937	Nonsense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	7256351	107575937	51562726	30	8988											
ASZ1	136991	broad.mit.edu	37	chr7	117024875	117024875	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagttcaagcaacttcaaaaCtatatttttatgaccctgac	4	9	2	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr7:117024875C>G	uc003vjb.2	-	6	655	c.592G>C	c.(592-594)GTT>CTT	p.V198L	ASZ1_uc011kno.1_Missense_Mutation_p.V198L|ASZ1_uc011knp.1_5'UTR	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	198	ANK 5.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			AACTTCAAAACTATATTTTTA	0.383													G	117024875	G	G	117024875	3	3	131	1	0	0	0	0	1	0	0	0	1069	565	20	5	867	5	ASZ1	7	117024875	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	9448938	117024875	42113788	31	8989											
IFNA10	3446	broad.mit.edu	37	chr9	21206859	21206859	+	Missense_Mutation	SNP	G	A	A													ctgctggatcatctcatggaGgacagagatggcttgagcct							TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr9:21206859G>A	uc003zoq.1	-	1	284	c.238C>T	c.(238-240)CTC>TTC	p.L80F	IFNA14_uc003zoo.1_Intron	NM_002171	NP_002162	P01566	IFN10_HUMAN	interferon, alpha 10 precursor	80					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		ATCTCATGGAGGACAGAGATG	0.483													A	21206859	A	A	21206859	3	1	131	1	0	0	0	0	1	0	0	0	7532	1000	35	3	335	3	IFNA10	9	21206859	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08		21206859	120006572	32	8990	13	2									
IFNA10	3446	broad.mit.edu	37	chr9	21206861	21206861	+	Missense_Mutation	SNP	A	G	G													gctggatcatctcatggaggAcagagatggcttgagccttc							TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr9:21206861A>G	uc003zoq.1	-	1	282	c.236T>C	c.(235-237)GTC>GCC	p.V79A	IFNA14_uc003zoo.1_Intron	NM_002171	NP_002162	P01566	IFN10_HUMAN	interferon, alpha 10 precursor	79					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		CTCATGGAGGACAGAGATGGC	0.488													G	21206861	G	G	21206861	3	3	131	1	0	0	0	0	1	0	0	0	7532	275	10	4	337	4	IFNA10	9	21206861	Missense_Mutation	SNP	A	TCGA-14-0790-01B-01D-1494-08	2	21206861	120006570	33	8991	13	2									
ZNF618	114991	broad.mit.edu	37	chr9	116750724	116750724	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggtgaagacagagctgccCgatgactacatccaggaggt	13	9	0	4			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr9:116750724C>T	uc004bid.2	+	3	300	c.201C>T	c.(199-201)CCC>CCT	p.P67P	ZNF618_uc004bib.1_Silent_p.P67P|ZNF618_uc004bic.2_Silent_p.P67P|ZNF618_uc011lxi.1_Silent_p.P67P|ZNF618_uc011lxj.1_Silent_p.P67P	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	67					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGAGCTGCCCGATGACTACA	0.632													T	116750724	T	T	116750724	2	4	131	1	0	0	0	0	0	0	0	1	18039	639	23	2		2	ZNF618	9	116750724	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	95543863	116750724	24462707	34	8992											
SNAPC4	6621	broad.mit.edu	37	chr9	139282191	139282192	+	Splice_Site	INS	-	A	A													tcctagggtcccgcacacttINSacagcatcttcctccggggc							TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr9:139282191_139282192insA	uc004chh.2	-	11	1239	c.1230_splice	c.e11+1	p.A410_splice		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,						snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CCCGCACACTTACAGCATCTTC	0.579													A	139282192	A	A	139282191	8	5	131	1	0	1	1	0	0	0	1	0	14837	1769	61	0		0	SNAPC4	9	139282191	Splice_Site	INS	-	TCGA-14-0790-01B-01D-1494-08	22531467	139282191	1931240	35	8993											
NOXA1	10811	broad.mit.edu	37	chr9	140325755	140325755	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgatgcagagacagaggtcGgtgctgaccgctgcacgtcg	15	11	0	3	rs141558298		TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr9:140325755G>A	uc004cmv.2	+	8	901	c.766G>A	c.(766-768)GGT>AGT	p.G256S	C9orf167_uc011mew.1_Intron|NOXA1_uc004cmu.2_Missense_Mutation_p.G256S|NOXA1_uc010nch.2_Missense_Mutation_p.G200S	NM_006647	NP_006638	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	256					regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity				0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)		GACAGAGGTCGGTGCTGACCG	0.672													A	140325755	A	A	140325755	3	1	131	1	0	0	0	0	1	0	0	0	10560	1116	39	2	796	2	NOXA1	9	140325755	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	1043564	140325755	887676	36	8994											
RTKN2	219790	broad.mit.edu	37	chr10	63957757	63957757	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	actggcttggcttcaaaattGgttttagtgtctgtgtgctc	11	7	2	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr10:63957757G>T	uc001jlw.2	-	12	1837	c.1740C>A	c.(1738-1740)ACC>ACA	p.T580T	RTKN2_uc009xpf.1_Intron|RTKN2_uc001jlv.2_Silent_p.T234T	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	580					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					CTTCAAAATTGGTTTTAGTGT	0.448													T	63957757	T	T	63957757	2	4	131	1	0	0	0	0	0	0	0	1	13723	1335	47	5		5	RTKN2	10	63957757	Silent	SNP	G	TCGA-14-0790-01B-01D-1494-08		63957757	71576990	37	8995											
CHUK	1147	broad.mit.edu	37	chr10	101981868	101981868	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tattttaatactgatacgtaCctatatcacttagtaaagaa	4	6	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr10:101981868C>T	uc001kqp.2	-	4	440	c.385_splice	c.e4+1	p.G129_splice		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase						I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		CTGATACGTACCTATATCACT	0.313													T	101981868	T	T	101981868	5	4	131	1	0	0	0	0	0	0	1	0	3416	521	18	3	1923	3	CHUK	10	101981868	Splice_Site	SNP	C	TCGA-14-0790-01B-01D-1494-08	38024111	101981868	33552879	38	8996											
LGR4	55366	broad.mit.edu	37	chr11	27390538	27390538	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttagacacagaaatcaagcCtataaacaatttggacgaag	8	7	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr11:27390538C>T	uc001mrj.3	-	18	2217	c.1732G>A	c.(1732-1734)GGC>AGC	p.G578S	LGR4_uc001mrk.3_Missense_Mutation_p.G554S	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	578	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						GAAATCAAGCCTATAAACAAT	0.378													T	27390538	T	T	27390538	3	4	131	1	0	0	0	0	1	0	0	0	8756	681	24	3	1127	3	LGR4	11	27390538	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08		27390538	107615978	39	8997											
HARBI1	283254	broad.mit.edu	37	chr11	46637480	46637480	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcagtgacattggcaacaCaacgactcatagacgcctga	8	12	2	3			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr11:46637480C>T	uc001ncy.2	-	2	556	c.308G>A	c.(307-309)TGT>TAT	p.C103Y	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	103						cytoplasm|nucleus	metal ion binding|nuclease activity				0						ATTGGCAACACAACGACTCAT	0.488													T	46637480	T	T	46637480	3	4	131	1	0	0	0	0	1	0	0	0	6958	478	17	3	749	3	HARBI1	11	46637480	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	19246942	46637480	88369036	40	8998											
VWF	7450	broad.mit.edu	37	chr12	6091103	6091103	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttccgaagggtgggcaaaCggtgcggggggcaggagggt	21	7	1	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr12:6091103C>T	uc001qnn.1	-	42	7386	c.7136G>A	c.(7135-7137)CGT>CAT	p.R2379H	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2379					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GGTGGGCAAACGGTGCGGGGG	0.612													T	6091103	T	T	6091103	3	4	131	1	0	0	0	0	1	0	0	0	17243	536	19	1	1349	1	VWF	12	6091103	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08		6091103	127760792	41	8999											
KRT3	3850	broad.mit.edu	37	chr12	53185580	53185580	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatccccatgcctgccagcCgtggtctgcagctcccccaa	8	19	2	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr12:53185580C>T	uc001say.2	-	6	1275	c.1209G>A	c.(1207-1209)ACG>ACA	p.T403T		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	403	Rod.|Coil 2.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						GCCTGCCAGCCGTGGTCTGCA	0.527													T	53185580	T	T	53185580	2	4	131	1	0	0	0	0	0	0	0	1	8466	639	23	2		2	KRT3	12	53185580	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	47094477	53185580	80666315	42	9000											
OR6C4	341418	broad.mit.edu	37	chr12	55945614	55945614	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatggtcatcctcttggccGttgtgactctcatggttact	10	10	3	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr12:55945614G>A	uc010spp.1	+	1	604	c.604G>A	c.(604-606)GTT>ATT	p.V202I		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTCTTGGCCGTTGTGACTCT	0.483													A	55945614	A	A	55945614	3	1	131	1	0	0	0	0	1	0	0	0	11193	1145	40	1	606	1	OR6C4	12	55945614	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	2760034	55945614	77906281	43	9001											
GLIPR1	11010	broad.mit.edu	37	chr12	75874782	75874782	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaagactgcgttcgaatccAtaacaagttccgatcagagg	9	10	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr12:75874782A>G	uc001sxs.2	+	1	270	c.122A>G	c.(121-123)CAT>CGT	p.H41R	GLIPR1_uc009zsb.1_Missense_Mutation_p.H41R	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	41					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						GTTCGAATCCATAACAAGTTC	0.378													G	75874782	G	G	75874782	3	3	131	1	0	0	0	0	1	0	0	0	6441	217	8	4	124	4	GLIPR1	12	75874782	Missense_Mutation	SNP	A	TCGA-14-0790-01B-01D-1494-08	19929168	75874782	57977113	44	9002											
MGAT4C	25834	broad.mit.edu	37	chr12	86373908	86373908	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatctacattttgcttggaaCgaaatttgactctatcttct	5	8	4	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr12:86373908C>T	uc001tai.3	-	8	1846	c.596G>A	c.(595-597)CGT>CAT	p.R199H	MGAT4C_uc001tal.3_Missense_Mutation_p.R199H|MGAT4C_uc001taj.3_Missense_Mutation_p.R199H|MGAT4C_uc001tak.3_Missense_Mutation_p.R199H|MGAT4C_uc010sum.1_Missense_Mutation_p.R223H|MGAT4C_uc001tah.3_Missense_Mutation_p.R199H	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	199	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TTGCTTGGAACGAAATTTGAC	0.338													T	86373908	T	T	86373908	3	4	131	1	0	0	0	0	1	0	0	0	9547	536	19	1	844	1	MGAT4C	12	86373908	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	10499126	86373908	47477987	45	9003											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100453163	100453163	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tactaaaaaaatcacaatctTtaaagtcttgaaacaaagct	3	7	3	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr12:100453163T>C	uc001tgq.2	-	14	2121	c.1892A>G	c.(1891-1893)AAA>AGA	p.K631R	UHRF1BP1L_uc001tgp.2_Missense_Mutation_p.K281R	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	631										ovary(2)	2						ATCACAATCTTTAAAGTCTTG	0.353													C	100453163	C	C	100453163	3	2	131	1	0	0	0	0	1	0	0	0	16966	1841	64	4	2534	4	UHRF1BP1L	12	100453163	Missense_Mutation	SNP	T	TCGA-14-0790-01B-01D-1494-08	14079255	100453163	33398732	46	9004											
SBNO1	55206	broad.mit.edu	37	chr12	123794339	123794339	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgcaaaatactgaaataaCgcattctgctgatgcacctc	6	12	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr12:123794339C>T	uc010tap.1	-	25	3360	c.3360G>A	c.(3358-3360)GCG>GCA	p.A1120A	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Silent_p.A1119A|SBNO1_uc010taq.1_Silent_p.A71A|SBNO1_uc001ues.1_Silent_p.A71A	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1120							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ACTGAAATAACGCATTCTGCT	0.328													T	123794339	T	T	123794339	2	4	131	1	0	0	0	0	0	0	0	1	13862	523	19	1		1	SBNO1	12	123794339	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	23341176	123794339	10057556	47	9005											
CDADC1	81602	broad.mit.edu	37	chr13	49865831	49865831	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caatgctagatggtgtgttgAgacctgtcccacagaaggaa	12	8	0	3			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr13:49865831A>C	uc001vcu.2	+	10	1559	c.1483A>C	c.(1483-1485)AGA>CGA	p.R495R	CDADC1_uc010tgk.1_Silent_p.R297R|CDADC1_uc001vcv.2_RNA	NM_030911	NP_112173	Q9BWV3	CDAC1_HUMAN	cytidine and dCMP deaminase domain containing 1	495							hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Lung NSC(96;0.000705)|Breast(56;0.0011)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;1.06e-08)|COAD - Colon adenocarcinoma(199;0.216)		TGGTGTGTTGAGACCTGTCCC	0.488													C	49865831	C	C	49865831	2	2	131	1	0	0	0	0	0	0	0	1	3053	296	11	5		5	CDADC1	13	49865831	Silent	SNP	A	TCGA-14-0790-01B-01D-1494-08		49865831	65304047	48	9006											
C13orf39	196541	broad.mit.edu	37	chr13	103343256	103343256	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctcctgagtgtagctggcGtaatctgtaggaacaaattt	11	7	1	1	rs140891650		TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr13:103343256G>A	uc001vpj.2	-	2	195	c.189C>T	c.(187-189)TAC>TAT	p.Y63Y	C13orf39_uc001vpk.2_Silent_p.Y63Y	NM_001010977	NP_001010977	Q5VZV1	MT21C_HUMAN	hypothetical protein LOC196541	63							methyltransferase activity				0						TGTAGCTGGCGTAATCTGTAG	0.443													A	103343256	A	A	103343256	2	1	131	1	0	0	0	0	0	0	0	1	1732	1140	40	1		1	C13orf39	13	103343256	Silent	SNP	G	TCGA-14-0790-01B-01D-1494-08	53477425	103343256	11826622	49	9007											
OR4N2	390429	broad.mit.edu	37	chr14	20295720	20295720	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttaatattctacttcatcaTcctccctggaaattttctca	2	11	4	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr14:20295720T>C	uc010tkv.1	+	1	113	c.113T>C	c.(112-114)ATC>ACC	p.I38T		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	38	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TACTTCATCATCCTCCCTGGA	0.438													C	20295720	C	C	20295720	3	2	131	1	0	0	0	0	1	0	0	0	11077	1435	50	4	115	4	OR4N2	14	20295720	Missense_Mutation	SNP	T	TCGA-14-0790-01B-01D-1494-08		20295720	87053820	50	9008											
RNASE11	122651	broad.mit.edu	37	chr14	21052495	21052495	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cattaatatctcaatggtctGtttttcttggccactttttg	6	8	3	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr14:21052495G>T	uc010ahv.2	-	2	324	c.139C>A	c.(139-141)CAG>AAG	p.Q47K	RNASE11_uc010ahx.2_Missense_Mutation_p.Q47K|RNASE11_uc010ahw.2_Missense_Mutation_p.Q47K|RNASE11_uc001vxs.2_Missense_Mutation_p.Q47K	NM_145250	NP_660293	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	47						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(3)	3	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		TCAATGGTCTGTTTTTCTTGG	0.378													T	21052495	T	T	21052495	3	4	131	1	0	0	0	0	1	0	0	0	13401	1386	48	5	464	5	RNASE11	14	21052495	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	756775	21052495	86297045	51	9009											
ARID4A	5926	broad.mit.edu	37	chr14	58831848	58831848	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accacttactcttagtcaagAtgagtctcgaagcgtaaaaa	7	9	3	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr14:58831848A>G	uc001xdp.2	+	20	3295	c.3041A>G	c.(3040-3042)GAT>GGT	p.D1014G	ARID4A_uc001xdo.2_Missense_Mutation_p.D1014G|ARID4A_uc001xdq.2_Missense_Mutation_p.D1014G|ARID4A_uc010apg.1_Missense_Mutation_p.D692G	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	1014					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						CTTAGTCAAGATGAGTCTCGA	0.413													G	58831848	G	G	58831848	3	3	131	1	0	0	0	0	1	0	0	0	919	333	12	4	3115	4	ARID4A	14	58831848	Missense_Mutation	SNP	A	TCGA-14-0790-01B-01D-1494-08	37779353	58831848	48517692	52	9010											
AHNAK2	113146	broad.mit.edu	37	chr14	105408457	105408457	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggacaggtccccctccagcCgcgtactgtccagcttggct	12	16	0	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr14:105408457C>T	uc010axc.1	-	7	13451	c.13331G>A	c.(13330-13332)CGG>CAG	p.R4444Q	AHNAK2_uc001ypx.2_Missense_Mutation_p.R4344Q	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4444						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCTCCAGCCGCGTACTGTC	0.587													T	105408457	T	T	105408457	3	4	131	1	0	0	0	0	1	0	0	0	415	652	23	2	4060	2	AHNAK2	14	105408457	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	46576609	105408457	1941083	53	9011											
PLCB2	5330	broad.mit.edu	37	chr15	40583002	40583002	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggccttcagctctgccgcctGtttctctctggccagctcca	9	17	4	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr15:40583002G>C	uc001zld.2	-	28	3374	c.3073C>G	c.(3073-3075)CAG>GAG	p.Q1025E	PLCB2_uc001zlc.2_Missense_Mutation_p.Q9E|PLCB2_uc010bbo.2_Missense_Mutation_p.Q1021E|PLCB2_uc010ucm.1_Missense_Mutation_p.Q1010E	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	1025	Potential.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		TCTGCCGCCTGTTTCTCTCTG	0.587													C	40583002	C	C	40583002	3	2	131	1	0	0	0	0	1	0	0	0	12028	1386	48	5	504	5	PLCB2	15	40583002	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08		40583002	61948390	54	9012											
VPS39	23339	broad.mit.edu	37	chr15	42457929	42457929	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accttaccagataaggaataGccagacccttaaaattctct	5	11	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr15:42457929G>A	uc001zpd.2	-	18	1950	c.1799C>T	c.(1798-1800)GCT>GTT	p.A600V	VPS39_uc001zpc.2_Missense_Mutation_p.A589V|VPS39_uc001zpb.2_5'UTR	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	600					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		ATAAGGAATAGCCAGACCCTT	0.443													A	42457929	A	A	42457929	3	1	131	1	0	0	0	0	1	0	0	0	17206	971	34	3	897	3	VPS39	15	42457929	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	1874927	42457929	60073463	55	9013											
SLC27A2	11001	broad.mit.edu	37	chr15	50518260	50518260	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgatgaaaatggatattgcGtcagagttcccaaaggtaca	11	6	1	3			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr15:50518260G>A	uc001zxw.2	+	6	1475	c.1243G>A	c.(1243-1245)GTC>ATC	p.V415I	SLC27A2_uc010bes.2_Missense_Mutation_p.V362I|SLC27A2_uc001zxx.2_Missense_Mutation_p.V180I	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	415	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		TGGATATTGCGTCAGAGTTCC	0.353													A	50518260	A	A	50518260	3	1	131	1	0	0	0	0	1	0	0	0	14526	1145	40	1	1265	1	SLC27A2	15	50518260	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	8060331	50518260	52013132	56	9014											
ACAN	176	broad.mit.edu	37	chr15	89395102	89395102	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggtgtggaggagtggatcGtgacccaagtggttcctggt	17	7	0	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr15:89395102G>A	uc010upo.1	+	11	2478	c.2104G>A	c.(2104-2106)GTG>ATG	p.V702M	ACAN_uc010upp.1_Missense_Mutation_p.V702M|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	702					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGAGTGGATCGTGACCCAAGT	0.567													A	89395102	A	A	89395102	3	1	131	1	0	0	0	0	1	0	0	0	117	1145	40	1	2142	1	ACAN	15	89395102	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	38876842	89395102	13136290	57	9015											
GRIN2A	2903	broad.mit.edu	37	chr16	9858195	9858195	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcaggttccctgtggcacGtggcccgatttgacgtttct	12	11	2	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr16:9858195G>A	uc002czo.3	-	13	3754	c.3206C>T	c.(3205-3207)ACG>ATG	p.T1069M	GRIN2A_uc010uym.1_Missense_Mutation_p.T1069M|GRIN2A_uc010uyn.1_Missense_Mutation_p.T912M|GRIN2A_uc002czr.3_Missense_Mutation_p.T1069M	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1069	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCTGTGGCACGTGGCCCGATT	0.502													A	9858195	A	A	9858195	3	1	131	1	0	0	0	0	1	0	0	0	6779	1145	40	1	1192	1	GRIN2A	16	9858195	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08		9858195	80496558	58	9016											
IL4R	3566	broad.mit.edu	37	chr16	27373745	27373745	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctggccagagagcatcagcGtggtgcgatgtgtggagttg	17	7	2	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr16:27373745G>A	uc002don.2	+	11	1314	c.1072G>A	c.(1072-1074)GTG>ATG	p.V358M	IL4R_uc002dop.3_Missense_Mutation_p.V343M|IL4R_uc010bxy.2_Missense_Mutation_p.V358M|IL4R_uc002doo.2_Missense_Mutation_p.V198M	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	358	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						GAGCATCAGCGTGGTGCGATG	0.562													A	27373745	A	A	27373745	3	1	131	1	0	0	0	0	1	0	0	0	7698	1145	40	1	1124	1	IL4R	16	27373745	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	17515550	27373745	62981008	59	9017											
CDH8	1006	broad.mit.edu	37	chr16	61687974	61687974	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attaatggttcatttttatgCcgccgtagagttacaaacag	8	7	1	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr16:61687974C>T	uc002eog.1	-	12	2190	c.1938G>A	c.(1936-1938)CGG>CGA	p.R646R		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	646	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R646Q(1)		ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CATTTTTATGCCGCCGTAGAG	0.388													T	61687974	T	T	61687974	2	4	131	1	0	0	0	0	0	0	0	1	3116	726	26	3		3	CDH8	16	61687974	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	34314229	61687974	28666779	60	9018											
C16orf7	9605	broad.mit.edu	37	chr16	89782935	89782935	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tcgggtggcagaaaaggagaGagctttcctccttcatcgga	13	9	1	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr16:89782935G>C	uc002fom.1	-	4	491	c.366C>G	c.(364-366)CTC>CTG	p.L122L	C16orf7_uc002fol.1_Silent_p.L52L|uc002fon.1_RNA|uc002foo.1_5'Flank	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	122					ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GAAAAGGAGAGAGCTTTCCTC	0.567													C	89782935	C	C	89782935	2	2	131	1	0	0	0	0	0	0	0	1	1828	929	33	5		5	C16orf7	16	89782935	Silent	SNP	G	TCGA-14-0790-01B-01D-1494-08	28094961	89782935	571818	61	9019											
PRPF8	10594	broad.mit.edu	37	chr17	1577046	1577046	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caacctagactcacaagttaAcatcatgtttcatgaggcgc	7	11	3	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr17:1577046A>G	uc002fte.2	-	22	3554	c.3440T>C	c.(3439-3441)GTT>GCT	p.V1147A		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1147						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCACAAGTTAACATCATGTTT	0.537													G	1577046	G	G	1577046	3	3	131	1	0	0	0	0	1	0	0	0	12575	43	2	4	3655	4	PRPF8	17	1577046	Missense_Mutation	SNP	A	TCGA-14-0790-01B-01D-1494-08		1577046	79618164	62	9020											
SPDYE4	388333	broad.mit.edu	37	chr17	8658859	8658859	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagccaggaagaaatgaatgCgttggtattgccacgagaag	14	6	0	3			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr17:8658859C>T	uc010cnz.1	-	4	641	c.464G>A	c.(463-465)CGC>CAC	p.R155H		NM_001128076	NP_001121548	A6NLX3	SPDE4_HUMAN	speedy homolog E4	155											0						GAAATGAATGCGTTGGTATTG	0.493													T	8658859	T	T	8658859	3	4	131	1	0	0	0	0	1	0	0	0	15030	768	27	1	261	1	SPDYE4	17	8658859	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	7081813	8658859	72536351	63	9021											
MYH4	4622	broad.mit.edu	37	chr17	10369590	10369590	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgttgaaagggtgctcacGtagatcatccaggctgcgta	13	9	2	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr17:10369590G>A	uc002gmn.2	-	4	459	c.348C>T	c.(346-348)TAC>TAT	p.Y116Y	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	116	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GGGTGCTCACGTAGATCATCC	0.433													A	10369590	A	A	10369590	2	1	131	1	0	0	0	0	0	0	0	1	10037	1159	40	1		1	MYH4	17	10369590	Silent	SNP	G	TCGA-14-0790-01B-01D-1494-08	1710731	10369590	70825620	64	9022											
ACCN1	40	broad.mit.edu	37	chr17	31351022	31351022	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtaattgctgtccttttcCgccaacagacctggagggga	11	11	0	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr17:31351022C>T	uc002hhu.2	-	6	1327	c.1053G>A	c.(1051-1053)GCG>GCA	p.A351A	ACCN1_uc002hht.2_Silent_p.A402A	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	351	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	TGTCCTTTTCCGCCAACAGAC	0.532													T	31351022	T	T	31351022	2	4	131	1	0	0	0	0	0	0	0	1	128	639	23	2		2	ACCN1	17	31351022	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	20981432	31351022	49844188	65	9023											
C17orf53	78995	broad.mit.edu	37	chr17	42225478	42225478	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggagcagctcccctaaggCctgtctctacttccagcagc	9	15	1	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr17:42225478C>T	uc002ifi.1	+	3	492	c.307C>T	c.(307-309)CCT>TCT	p.P103S	C17orf53_uc010czq.1_Missense_Mutation_p.P103S|C17orf53_uc002ifj.1_Missense_Mutation_p.P103S|C17orf53_uc002ifk.1_RNA	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	103											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		TCCCCTAAGGCCTGTCTCTAC	0.577													T	42225478	T	T	42225478	3	4	131	1	0	0	0	0	1	0	0	0	1862	739	26	3	317	3	C17orf53	17	42225478	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	10874456	42225478	38969732	66	9024											
CTDP1	9150	broad.mit.edu	37	chr18	77513692	77513692	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atgaagaggacgccgccagcGagtccagcagggagtccagc	15	12	0	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr18:77513692G>A	uc002lnh.1	+	13	2935	c.2788G>A	c.(2788-2790)GAG>AAG	p.E930K	CTDP1_uc002lni.1_3'UTR|CTDP1_uc010drd.1_3'UTR	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	930					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CGCCGCCAGCGAGTCCAGCAG	0.617													A	77513692	A	A	77513692	3	1	131	1	0	0	0	0	1	0	0	0	4002	1059	37	2	2838	2	CTDP1	18	77513692	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08		77513692	563556	67	9025											
MATK	4145	broad.mit.edu	37	chr19	3783948	3783948	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agtcgccggggtggcgcgcgGactcccgcaccaggaacagc	16	15	0	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr19:3783948G>T	uc002lyt.2	-	6	846	c.446C>A	c.(445-447)TCC>TAC	p.S149Y	MATK_uc002lyv.2_Missense_Mutation_p.S150Y|MATK_uc002lyu.2_Missense_Mutation_p.S108Y|MATK_uc010dtq.2_Missense_Mutation_p.S149Y	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	149	SH2.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGCGCGCGGACTCCCGCAC	0.682													T	3783948	T	T	3783948	3	4	131	1	0	0	0	0	1	0	0	0	9332	1174	41	5	1113	5	MATK	19	3783948	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08		3783948	55345035	68	9026											
NCAN	1463	broad.mit.edu	37	chr19	19351446	19351446	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacacgtggatcggcctgaaCgacaggatcgtggagagaga	15	8	0	3			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr19:19351446C>T	uc002nlz.2	+	12	3543	c.3444C>T	c.(3442-3444)AAC>AAT	p.N1148N	NCAN_uc002nma.2_Translation_Start_Site	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1148	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			TCGGCCTGAACGACAGGATCG	0.637													T	19351446	T	T	19351446	2	4	131	1	0	0	0	0	0	0	0	1	10204	535	19	1		1	NCAN	19	19351446	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	15567498	19351446	39777537	69	9027											
NR1H2	7376	broad.mit.edu	37	chr19	50882422	50882423	+	Frame_Shift_Ins	INS	-	G	G													gaccagatcgccctcctgaaINSggcatccactatcgaggtaa							TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr19:50882422_50882423insG	uc010enw.2	+	8	1190_1191	c.914_915insG	c.(913-915)AAGfs	p.K305fs	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Frame_Shift_Ins_p.K260fs|NR1H2_uc002psa.3_Frame_Shift_Ins_p.K207fs	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	304	Ligand-binding (Potential).				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GCCCTCCTGAAGGCATCCACTA	0.574													G	50882423	G	G	50882422	7	5	131	1	0	1	1	0	0	0	0	0	10617	72	3	0	929	0	NR1H2	19	50882422	Frame_Shift_Ins	INS	-	TCGA-14-0790-01B-01D-1494-08	31530976	50882422	8246561	70	9028											
KIR2DL1	3802	broad.mit.edu	37	chr19	55284915	55284915	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacagagaggggatgtttaaCgacactttgcgcctcattgg	12	9	1	1	rs144426670	byFrequency	TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr19:55284915C>T	uc002qhb.1	+	3	239	c.201C>T	c.(199-201)AAC>AAT	p.N67N	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Silent_p.N67N	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	67	Extracellular (Potential).|Ig-like C2-type 1.				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		GGATGTTTAACGACACTTTGC	0.517													T	55284915	T	T	55284915	2	4	131	1	0	0	0	0	0	0	0	1	8316	535	19	1		1	KIR2DL1	19	55284915	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	4402493	55284915	3844068	71	9029											
ZSCAN1	284312	broad.mit.edu	37	chr19	58565272	58565272	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcaagggcccccgggagtcCgtcccacccagggatggagc	15	15	0	0	rs144381428		TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr19:58565272C>T	uc002qrc.1	+	6	1327	c.1080C>T	c.(1078-1080)TCC>TCT	p.S360S		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	360					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCCGGGAGTCCGTCCCACCCA	0.662													T	58565272	T	T	58565272	2	4	131	1	0	0	0	0	0	0	0	1	18223	639	23	2		2	ZSCAN1	19	58565272	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	3280357	58565272	563711	72	9030											
CRYBB2	1415	broad.mit.edu	37	chr22	25627599	25627599	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctaccagtaccccggctacCgtgggctgcagtacctgctg	12	15	0	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chr22:25627599C>T	uc003abp.1	+	6	526	c.478C>T	c.(478-480)CGT>TGT	p.R160C		NM_000496	NP_000487	P43320	CRBB2_HUMAN	crystallin, beta B2	160	Beta/gamma crystallin 'Greek key' 4.				response to stimulus|visual perception		structural constituent of eye lens				0						CCCCGGCTACCGTGGGCTGCA	0.473													T	25627599	T	T	25627599	3	4	131	1	0	0	0	0	1	0	0	0	3911	652	23	2	496	2	CRYBB2	22	25627599	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08		25627599	25676967	73	9031											
ARHGAP6	395	broad.mit.edu	37	chrX	11160414	11160414	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgccaagttccccagatatcGaaaggctcctctgacagatc	8	13	1	3			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chrX:11160414G>A	uc004cup.1	-	12	3069	c.2196C>T	c.(2194-2196)TTC>TTT	p.F732F	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cum.1_Silent_p.F529F|ARHGAP6_uc004cun.1_Silent_p.F552F	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	732					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CCCAGATATCGAAAGGCTCCT	0.318													A	11160414	A	A	11160414	2	1	131	1	0	0	0	0	0	0	0	1	887	1049	37	2		2	ARHGAP6	23	11160414	Silent	SNP	G	TCGA-14-0790-01B-01D-1494-08		11160414	144110146	74	9032											
SCML2	10389	broad.mit.edu	37	chrX	18348708	18348708	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaattactttaaaacctaccCctttgtacagaagatgtact	4	9	0	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chrX:18348708C>T	uc004cyl.2	-	3	247	c.90G>A	c.(88-90)AGG>AGA	p.R30R	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Silent_p.R30R|SCML2_uc011miz.1_Intron	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	30					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					AAAACCTACCCCTTTGTACAG	0.308													T	18348708	T	T	18348708	2	4	131	1	0	0	0	0	0	0	0	1	13910	637	22	3		3	SCML2	23	18348708	Silent	SNP	C	TCGA-14-0790-01B-01D-1494-08	7188294	18348708	136921852	75	9033											
DCAF8L2	347442	broad.mit.edu	37	chrX	27765650	27765650	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgaggcctgtggggcaagagCctttgtgcagcgtttccgcc	15	11	0	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chrX:27765650C>A	uc011mjy.1	+	1	725	c.638C>A	c.(637-639)GCC>GAC	p.A213D		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						GGGGCAAGAGCCTTTGTGCAG	0.592													A	27765650	A	A	27765650	3	1	131	1	0	0	0	0	1	0	0	0	4278	739	26	5	640	5	DCAF8L2	23	27765650	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	9416942	27765650	127504910	76	9034											
FAM47C	442444	broad.mit.edu	37	chrX	37028542	37028542	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggagcctccagagactcgcGtatctcatctccgcccagag	10	16	2	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chrX:37028542G>A	uc004ddl.1	+	1	2073	c.2059G>A	c.(2059-2061)GTA>ATA	p.V687I		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	687										ovary(3)	3						AGAGACTCGCGTATCTCATCT	0.657													A	37028542	A	A	37028542	3	1	131	1	0	0	0	0	1	0	0	0	5571	1145	40	1	2061	1	FAM47C	23	37028542	Missense_Mutation	SNP	G	TCGA-14-0790-01B-01D-1494-08	9262892	37028542	118242018	77	9035											
BCORL1	63035	broad.mit.edu	37	chrX	129149265	129149265	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtccccgtaccaccaggcGtctctgctttccattggcat	9	15	1	0			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chrX:129149265G>A	uc004evb.1	+	4	2631	c.2517G>A	c.(2515-2517)GCG>GCA	p.A839A	BCORL1_uc010nrd.1_Silent_p.A741A	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	839					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						ACCACCAGGCGTCTCTGCTTT	0.607													A	129149265	A	A	129149265	2	1	131	1	0	0	0	0	0	0	0	1	1387	1132	40	1		1	BCORL1	23	129149265	Silent	SNP	G	TCGA-14-0790-01B-01D-1494-08	92120723	129149265	26121295	78	9036											
GPR112	139378	broad.mit.edu	37	chrX	135485475	135485475	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggaactctgagcccaacaaCtccgttgtaagtaccagcat	8	12	1	1			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chrX:135485475C>A	uc004ezu.1	+	22	8939	c.8648C>A	c.(8647-8649)ACT>AAT	p.T2883N	GPR112_uc010nsb.1_Missense_Mutation_p.T2678N	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2883	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AGCCCAACAACTCCGTTGTAA	0.498													A	135485475	A	A	135485475	3	1	131	1	0	0	0	0	1	0	0	0	6629	565	20	5	8722	5	GPR112	23	135485475	Missense_Mutation	SNP	C	TCGA-14-0790-01B-01D-1494-08	6336210	135485475	19785085	79	9037											
RBMX	27316	broad.mit.edu	37	chrX	135961572	135961572	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atgaagagctttcctgggcgAtctgcttcaaccatgttttt	9	9	2	2			TCGA-14-0790-01B-01D-1494-08	TCGA-14-0790-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d63d49a0-9413-4583-a7a5-cb2c202cc085	c5b89205-c40f-42e9-bde7-3a95e32bb631	g.chrX:135961572A>T	uc004fae.1	-	2	225	c.15T>A	c.(13-15)GAT>GAA	p.D5E	RBMX_uc011mwf.1_Missense_Mutation_p.D5E|RBMX_uc004fad.1_Missense_Mutation_p.D5E|RBMX_uc011mwg.1_5'UTR|RBMX_uc004faf.1_5'UTR|RBMX_uc010nsf.1_Intron|RBMX_uc004fag.1_Intron|SNORD61_uc004fah.1_5'Flank	NM_002139	NP_002130	P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked isoform 1	5						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TTCCTGGGCGATCTGCTTCAA	0.403													T	135961572	T	T	135961572	3	4	131	1	0	0	0	0	1	0	0	0	13151	330	12	5	1247	5	RBMX	23	135961572	Missense_Mutation	SNP	A	TCGA-14-0790-01B-01D-1494-08	476097	135961572	19308988	80	9038											
MASP2	10747	broad.mit.edu	37	chr1	11107017	11107017	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaagtagaggcgcaggcgGtagccggggggtgcagtcag	21	7	1	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:11107017G>A	uc001aru.2	-	2	186	c.165C>T	c.(163-165)TAC>TAT	p.Y55Y	MASP2_uc001arv.2_Silent_p.Y55Y|MASP2_uc001arw.2_Silent_p.Y55Y|MASP2_uc001arx.1_Silent_p.Y55Y	NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	55	CUB 1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		GGCGCAGGCGGTAGCCGGGGG	0.657													A	11107017	A	A	11107017	2	1	132	1	0	0	0	0	0	0	0	1	9323	1256	44	3		3	MASP2	1	11107017	Silent	SNP	G	TCGA-14-0813-01A-01W-0424-08		11107017	238143604	1	9039											
ZNF362	149076	broad.mit.edu	37	chr1	33745906	33745906	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cctctcctggactccatcaaGacaatccagggccacggcct	8	17	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:33745906G>C	uc001bxc.1	+	5	701	c.531G>C	c.(529-531)AAG>AAC	p.K177N		NM_152493	NP_689706	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				ACTCCATCAAGACAATCCAGG	0.667													C	33745906	C	C	33745906	3	2	132	1	0	0	0	0	1	0	0	0	17865	933	33	5	545	5	ZNF362	1	33745906	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	22638889	33745906	215504715	2	9040											
KLF17	128209	broad.mit.edu	37	chr1	44595485	44595485	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctccagtgccttaccctgGcctctcgacagtaccttctg	7	18	2	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:44595485G>A	uc001clp.2	+	2	600	c.542G>A	c.(541-543)GGC>GAC	p.G181D	KLF17_uc009vxf.1_Missense_Mutation_p.G144D	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	181					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CCTTACCCTGGCCTCTCGACA	0.597													A	44595485	A	A	44595485	3	1	132	1	0	0	0	0	1	0	0	0	8345	1203	42	3	548	3	KLF17	1	44595485	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	10849579	44595485	204655136	3	9041											
LRRC7	57554	broad.mit.edu	37	chr1	70489054	70489054	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cttccctctctaagtggcagAcaggtaggcctaggtgtctg	12	11	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:70489054A>T	uc001dep.2	+	15	1707	c.1677A>T	c.(1675-1677)AGA>AGT	p.R559S	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	559						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TAAGTGGCAGACAGGTAGGCC	0.507													T	70489054	T	T	70489054	3	4	132	1	0	0	0	0	1	0	0	0	9020	272	10	5	1735	5	LRRC7	1	70489054	Missense_Mutation	SNP	A	TCGA-14-0813-01A-01W-0424-08	25893569	70489054	178761567	4	9042											
NEGR1	257194	broad.mit.edu	37	chr1	72400892	72400892	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcccttttattcaatgttgaAattgaaactcgaggatccac	6	9	1	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:72400892A>C	uc001dfw.2	-	2	379	c.279T>G	c.(277-279)ATT>ATG	p.I93M	NEGR1_uc001dfv.2_Translation_Start_Site|NEGR1_uc010oqs.1_Missense_Mutation_p.I93M	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	93	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		TCAATGTTGAAATTGAAACTC	0.443													C	72400892	C	C	72400892	3	2	132	1	0	0	0	0	1	0	0	0	10317	10	1	5	809	5	NEGR1	1	72400892	Missense_Mutation	SNP	A	TCGA-14-0813-01A-01W-0424-08	1911838	72400892	176849729	5	9043											
MOV10	4343	broad.mit.edu	37	chr1	113232671	113232671	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaagcggacccggatcaccGgaaaccctgtggtgaccaat	11	13	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:113232671G>A	uc001eck.2	+	5	1057	c.787G>A	c.(787-789)GGA>AGA	p.G263R	MOV10_uc001ecl.2_Missense_Mutation_p.G263R|MOV10_uc001ecn.2_Missense_Mutation_p.G263R|MOV10_uc001ecm.2_Missense_Mutation_p.G203R|MOV10_uc009wgj.1_Missense_Mutation_p.G203R	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	263					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CCGGATCACCGGAAACCCTGT	0.602													A	113232671	A	A	113232671	3	1	132	1	0	0	0	0	1	0	0	0	9718	1117	39	2	801	2	MOV10	1	113232671	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	40831779	113232671	136017950	6	9044											
INSRR	3645	broad.mit.edu	37	chr1	156816384	156816384	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtcctcctcagtggttagCgtgatggcccgcacaaacac	10	14	1	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:156816384C>T	uc010pht.1	-	8	1991	c.1737G>A	c.(1735-1737)ACG>ACA	p.T579T	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	579	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CAGTGGTTAGCGTGATGGCCC	0.607													T	156816384	T	T	156816384	2	4	132	1	0	0	0	0	0	0	0	1	7774	755	27	1		1	INSRR	1	156816384	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	43583713	156816384	92434237	7	9045											
OR10Z1	128368	broad.mit.edu	37	chr1	158576316	158576316	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcagctccttctctttgccTtgttcctctctctgtatcta	5	14	4	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:158576316T>C	uc010pio.1	+	1	88	c.88T>C	c.(88-90)TTG>CTG	p.L30L		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TCTCTTTGCCTTGTTCCTCTC	0.502													C	158576316	C	C	158576316	2	2	132	1	0	0	0	0	0	0	0	1	10923	1606	56	4		4	OR10Z1	1	158576316	Silent	SNP	T	TCGA-14-0813-01A-01W-0424-08	1759932	158576316	90674305	8	9046											
ATF6	22926	broad.mit.edu	37	chr1	161816315	161816315	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaggcaccttctaggatttTctgctaaagaggcacaggac	12	9	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:161816315T>C	uc001gbr.2	+	10	1331	c.1264T>C	c.(1264-1266)TCT>CCT	p.S422P	ATF6_uc001gbq.1_Missense_Mutation_p.S422P	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	422	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TCTAGGATTTTCTGCTAAAGA	0.403													C	161816315	C	C	161816315	3	2	132	1	0	0	0	0	1	0	0	0	1084	1783	62	4	1302	4	ATF6	1	161816315	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	3239999	161816315	87434306	9	9047											
GORAB	92344	broad.mit.edu	37	chr1	170511696	170511696	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taatggaagagaaaaataaaCgtaaaaaagctcttttggct	8	4	1	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:170511696C>T	uc001gha.2	+	3	586	c.559C>T	c.(559-561)CGT>TGT	p.R187C	GORAB_uc001ggz.3_Missense_Mutation_p.R187C|GORAB_uc009wvx.2_Missense_Mutation_p.R7C|GORAB_uc001ghb.2_Missense_Mutation_p.R7C|GORAB_uc001ghc.2_Missense_Mutation_p.R7C|GORAB_uc001ghd.2_5'Flank	NM_152281	NP_689494	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting isoform a	187	Potential.					Golgi apparatus|nucleus					0						GAAAAATAAACGTAAAAAAGC	0.398													T	170511696	T	T	170511696	3	4	132	1	0	0	0	0	1	0	0	0	6574	536	19	1	569	1	GORAB	1	170511696	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	8695381	170511696	78738925	10	9048											
PAPPA2	60676	broad.mit.edu	37	chr1	176526282	176526282	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgggagcggctgctgctgcGtccagaagtgctggctgaga	18	10	0	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:176526282G>A	uc001gkz.2	+	2	1988	c.824G>A	c.(823-825)CGT>CAT	p.R275H	PAPPA2_uc001gky.1_Missense_Mutation_p.R275H|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	275					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CTGCTGCTGCGTCCAGAAGTG	0.577													A	176526282	A	A	176526282	3	1	132	1	0	0	0	0	1	0	0	0	11433	1145	40	1	826	1	PAPPA2	1	176526282	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	6014586	176526282	72724339	11	9049											
HMCN1	83872	broad.mit.edu	37	chr1	186062774	186062774	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctctctcctcccatatccGgttactggcagcaggacaag	9	15	1	0	rs143555094		TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:186062774G>A	uc001grq.1	+	66	10398	c.10169G>A	c.(10168-10170)CGG>CAG	p.R3390Q		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3390	Ig-like C2-type 32.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TCCCATATCCGGTTACTGGCA	0.428													A	186062774	A	A	186062774	3	1	132	1	0	0	0	0	1	0	0	0	7220	1116	39	2	10431	2	HMCN1	1	186062774	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	9536492	186062774	63187847	12	9050											
AVPR1B	553	broad.mit.edu	37	chr1	206224826	206224826	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacatgctgctggccatgaCgctggaccgctacctggctg	12	14	0	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:206224826C>T	uc001hds.2	+	1	544	c.386C>T	c.(385-387)ACG>ATG	p.T129M		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	129	Helical; Name=3; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity	p.T129M(1)		ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CTGGCCATGACGCTGGACCGC	0.657													T	206224826	T	T	206224826	3	4	132	1	0	0	0	0	1	0	0	0	1232	536	19	1	388	1	AVPR1B	1	206224826	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	20162052	206224826	43025795	13	9051											
CD55	1604	broad.mit.edu	37	chr1	207500170	207500170	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagtggagtgacccgttgCcagagtgcagaggtaagagt	15	8	0	4			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:207500170C>T	uc001hfq.3	+	5	946	c.652C>T	c.(652-654)CCA>TCA	p.P218S	CD55_uc001hfp.3_Missense_Mutation_p.P218S|CD55_uc001hfr.3_Missense_Mutation_p.P218S|CD55_uc010psf.1_RNA|CD55_uc009xcf.2_Missense_Mutation_p.P154S|CD55_uc009xce.2_Missense_Mutation_p.P218S|CD55_uc009xcg.2_5'UTR	NM_000574	NP_000565	P08174	DAF_HUMAN	decay accelerating factor for complement isoform	218	Sushi 3.				complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			ovary(1)	1					Chloramphenicol(DB00446)	TGACCCGTTGCCAGAGTGCAG	0.403													T	207500170	T	T	207500170	3	4	132	1	0	0	0	0	1	0	0	0	3024	739	26	3	670	3	CD55	1	207500170	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	1275344	207500170	41750451	14	9052											
SIPA1L2	57568	broad.mit.edu	37	chr1	232581433	232581433	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagtgggcacccggtgccaCgtggtgttcctcctgaaggg	17	11	0	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:232581433C>T	uc001hvg.2	-	9	3353	c.3195G>A	c.(3193-3195)ACG>ACA	p.T1065T	SIPA1L2_uc001hvf.2_Silent_p.T139T	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1065					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCCGGTGCCACGTGGTGTTCC	0.642													T	232581433	T	T	232581433	2	4	132	1	0	0	0	0	0	0	0	1	14330	523	19	1		1	SIPA1L2	1	232581433	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	25081263	232581433	16669188	15	9053											
OR2L13	284521	broad.mit.edu	37	chr1	248262881	248262881	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcagccagctctcccttatGgacctgatgtacatctccac	6	16	3	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:248262881G>T	uc001ids.2	+	3	541	c.204G>T	c.(202-204)ATG>ATT	p.M68I		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TCTCCCTTATGGACCTGATGT	0.547													T	248262881	T	T	248262881	3	4	132	1	0	0	0	0	1	0	0	0	11006	1348	47	5	206	5	OR2L13	1	248262881	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	15681448	248262881	987740	16	9054											
OR2T4	127074	broad.mit.edu	37	chr1	248525679	248525679	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgaactcagcagagggccGgaaaaaggcctttgccacct	12	11	1	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr1:248525679G>A	uc001ieh.1	+	1	797	c.797G>A	c.(796-798)CGG>CAG	p.R266Q		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	266	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCAGAGGGCCGGAAAAAGGCC	0.547													A	248525679	A	A	248525679	3	1	132	1	0	0	0	0	1	0	0	0	11027	1116	39	2	799	2	OR2T4	1	248525679	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	262798	248525679	724942	17	9055											
NBAS	51594	broad.mit.edu	37	chr2	15417158	15417158	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gtgctggtgaaaggcttctgGatcagtcttcaaagtctcaa	11	8	5	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr2:15417158G>T	uc002rcc.1	-	43	5232	c.5206C>A	c.(5206-5208)CCA>ACA	p.P1736T	NBAS_uc010exl.1_Missense_Mutation_p.P808T|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1736										ovary(2)|liver(1)|skin(1)	4						AAGGCTTCTGGATCAGTCTTC	0.398													T	15417158	T	T	15417158	3	4	132	1	0	0	0	0	1	0	0	0	10186	1174	41	5	1949	5	NBAS	2	15417158	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08		15417158	227782215	18	9056											
ASXL2	55252	broad.mit.edu	37	chr2	25965918	25965918	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgtggagatgtcttccagCtggaaacctgagtgagcgaa	13	8	1	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr2:25965918C>T	uc002rgs.2	-	12	3509	c.3288G>A	c.(3286-3288)CAG>CAA	p.Q1096Q	ASXL2_uc002rgt.1_Silent_p.Q579Q	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	1096					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTCTTCCAGCTGGAAACCTG	0.493													T	25965918	T	T	25965918	2	4	132	1	0	0	0	0	0	0	0	1	1067	796	28	3		3	ASXL2	2	25965918	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	10548760	25965918	217233455	19	9057											
IL18R1	8809	broad.mit.edu	37	chr2	102984390	102984390	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gattgaaacaaccaccaaaaGctggtacaaaagcagtggat	9	8	0	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr2:102984390G>T	uc002tbw.3	+	3	314	c.164G>T	c.(163-165)AGC>ATC	p.S55I	IL18R1_uc010ywb.1_Missense_Mutation_p.S55I|IL18R1_uc010ywc.1_Missense_Mutation_p.S55I|IL18R1_uc010ywd.1_Intron|IL18R1_uc010fiy.2_Missense_Mutation_p.S55I	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	55	Ig-like C2-type 1.|Extracellular (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						ACCACCAAAAGCTGGTACAAA	0.448													T	102984390	T	T	102984390	3	4	132	1	0	0	0	0	1	0	0	0	7647	971	34	5	170	5	IL18R1	2	102984390	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	77018472	102984390	140214983	20	9058											
SCN7A	6332	broad.mit.edu	37	chr2	167263066	167263066	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctttggtccttttccaagaCgcagcatgtgaatgatccgt	9	11	0	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr2:167263066C>T	uc002udu.1	-	25	4200	c.4073G>A	c.(4072-4074)CGT>CAT	p.R1358H		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1358	Helical; Voltage-sensor; Name=S4 of repeat IV; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TTTTCCAAGACGCAGCATGTG	0.468													T	167263066	T	T	167263066	3	4	132	1	0	0	0	0	1	0	0	0	13923	536	19	1	979	1	SCN7A	2	167263066	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	64278676	167263066	75936307	21	9059											
ITGA6	3655	broad.mit.edu	37	chr2	173338970	173338970	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatttggctatgatgtggcGgtggtggacctcaacaagga	14	7	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr2:173338970G>A	uc002uhp.1	+	6	1166	c.963G>A	c.(961-963)GCG>GCA	p.A321A	ITGA6_uc010fqk.1_Silent_p.A207A|ITGA6_uc010zdy.1_Silent_p.A202A|ITGA6_uc002uho.1_Silent_p.A321A|ITGA6_uc010fqm.1_5'Flank	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	360	FG-GAP 5.|Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			ATGATGTGGCGGTGGTGGACC	0.483													A	173338970	A	A	173338970	2	1	132	1	0	0	0	0	0	0	0	1	7880	1103	39	2		2	ITGA6	2	173338970	Silent	SNP	G	TCGA-14-0813-01A-01W-0424-08	6075904	173338970	69860403	22	9060											
TTN	7273	broad.mit.edu	37	chr2	179528769	179528769	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggtgggacttcaggcttttTaggaggcaccaccgacactt	12	10	1	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr2:179528769T>G	uc010zfk.1	-	14	1323	c.775A>C	c.(775-777)AAA>CAA	p.K259Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	11471							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R256_K260>K(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGGCTTTTTAGGAGGCACC	0.388													G	179528769	G	G	179528769	3	3	132	1	0	0	0	0	1	0	0	0	16732	1769	61	5		5	TTN	2	179528769	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	6189799	179528769	63670604	23	9061											
ALPP	250	broad.mit.edu	37	chr2	233246043	233246043	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggctatgtgctcaaggaCggcgcccggccggatgttac	14	13	1	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr2:233246043C>T	uc002vsq.2	+	10	1440	c.1275C>T	c.(1273-1275)GAC>GAT	p.D425D	ALPP_uc002vsr.2_RNA	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	425						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TGCTCAAGGACGGCGCCCGGC	0.697													T	233246043	T	T	233246043	2	4	132	1	0	0	0	0	0	0	0	1	548	535	19	1		1	ALPP	2	233246043	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	53717274	233246043	9953330	24	9062											
COL6A3	1293	broad.mit.edu	37	chr2	238275874	238275874	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcacttcctggaaactgtcCctcctgaagttgatggaacc	9	12	0	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr2:238275874C>T	uc002vwl.2	-	11	5241	c.4956G>A	c.(4954-4956)AGG>AGA	p.R1652R	COL6A3_uc002vwo.2_Silent_p.R1446R|COL6A3_uc010znj.1_Silent_p.R1045R	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1652	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGAAACTGTCCCTCCTGAAGT	0.433													T	238275874	T	T	238275874	2	4	132	1	0	0	0	0	0	0	0	1	3701	622	22	3		3	COL6A3	2	238275874	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	5029831	238275874	4923499	25	9063											
OR6B2	389090	broad.mit.edu	37	chr2	240969715	240969715	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctccagacgatgaggatgatGgccaggttctccaccaggac	12	12	1	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr2:240969715G>T	uc002vyr.2	-	2	178	c.132C>A	c.(130-132)GCC>GCA	p.A44A	OR6B2_uc010zoc.1_Silent_p.A44A	NM_001005853	NP_001005853	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		TGAGGATGATGGCCAGGTTCT	0.577													T	240969715	T	T	240969715	2	4	132	1	0	0	0	0	0	0	0	1	11188	1335	47	5		5	OR6B2	2	240969715	Silent	SNP	G	TCGA-14-0813-01A-01W-0424-08	2693841	240969715	2229658	26	9064											
CHL1	10752	broad.mit.edu	37	chr3	424158	424158	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tccctgtttatactaccagaGtatattgttgaatttgaagg	8	6	0	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr3:424158G>T	uc003bou.2	+	17	2203	c.1932G>T	c.(1930-1932)GAG>GAT	p.E644D	CHL1_uc003bot.2_Missense_Mutation_p.E660D|CHL1_uc003bow.1_Missense_Mutation_p.E644D|CHL1_uc011asi.1_Missense_Mutation_p.E660D|uc003box.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	644	Fibronectin type-III 1.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TACTACCAGAGTATATTGTTG	0.338													T	424158	T	T	424158	3	4	132	1	0	0	0	0	1	0	0	0	3349	1043	36	5	2042	5	CHL1	3	424158	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08		424158	197598272	27	9065											
POLQ	10721	broad.mit.edu	37	chr3	121206922	121206922	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttgcctggtcccagttaatTttgatttttcagccctttca	6	10	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr3:121206922T>G	uc003eee.3	-	16	4985	c.4856A>C	c.(4855-4857)AAA>ACA	p.K1619T	POLQ_uc003eed.2_Missense_Mutation_p.K791T	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1619					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CCCAGTTAATTTTGATTTTTC	0.408								DNA_polymerases_(catalytic_subunits)					G	121206922	G	G	121206922	3	3	132	1	0	0	0	0	1	0	0	0	12208	1841	64	5	2976	5	POLQ	3	121206922	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	120782764	121206922	76815508	28	9066											
PRR23C	389152	broad.mit.edu	37	chr3	138762733	138762733	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgctctgggagctccgggcGcgcgtggggacctggactcg	19	13	1	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr3:138762733G>A	uc011bmt.1	-	1	1002	c.730C>T	c.(730-732)CGC>TGC	p.R244C		NM_001134657	NP_001128129	Q6ZRP0	PR23C_HUMAN	proline rich 23C	244	Pro-rich.									skin(1)	1						AGCTCCGGGCGCGCGTGGGGA	0.642													A	138762733	A	A	138762733	3	1	132	1	0	0	0	0	1	0	0	0	12596	1087	38	1	62	1	PRR23C	3	138762733	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	17555811	138762733	59259697	29	9067											
NMNAT3	349565	broad.mit.edu	37	chr3	139297857	139297857	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctttcttcccataggtgtcGttgacaggagagatgatacc	10	9	2	3	rs79043406	byFrequency	TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr3:139297857G>A	uc003etj.2	-	2	190	c.150C>T	c.(148-150)AAC>AAT	p.N50N	NMNAT3_uc003etk.2_Silent_p.N13N|NMNAT3_uc003etl.2_RNA|NMNAT3_uc010hul.2_Intron	NM_178177	NP_835471	Q96T66	NMNA3_HUMAN	nicotinamide mononucleotide adenylyltransferase	50					water-soluble vitamin metabolic process	cytosol|mitochondrion	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity				0						CATAGGTGTCGTTGACAGGAG	0.572													A	139297857	A	A	139297857	2	1	132	1	0	0	0	0	0	0	0	1	10500	1136	40	1		1	NMNAT3	3	139297857	Silent	SNP	G	TCGA-14-0813-01A-01W-0424-08	535124	139297857	58724573	30	9068											
MCF2L2	23101	broad.mit.edu	37	chr3	182897228	182897228	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctggaaaccagccgtcgcCcccgcaggagccagccggcc	13	19	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr3:182897228C>T	uc003fli.1	-	30	3375	c.3285G>A	c.(3283-3285)GGG>GGA	p.G1095G		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	1095					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CAGCCGTCGCCCCCGCAGGAG	0.741													T	182897228	T	T	182897228	2	4	132	1	0	0	0	0	0	0	0	1	9380	610	22	3		3	MCF2L2	3	182897228	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	43599371	182897228	15125202	31	9069											
DRD5	1816	broad.mit.edu	37	chr4	9784506	9784506	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgcgcccgacaccagcctgCgcgcttccatcaagaaggag	12	16	1	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr4:9784506C>T	uc003gmb.3	+	1	1249	c.853C>T	c.(853-855)CGC>TGC	p.R285C		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	285	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CACCAGCCTGCGCGCTTCCAT	0.627													T	9784506	T	T	9784506	3	4	132	1	0	0	0	0	1	0	0	0	4760	768	27	1	855	1	DRD5	4	9784506	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08		9784506	181369770	32	9070											
PCDH7	5099	broad.mit.edu	37	chr4	30724196	30724196	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgaaccagctgcgcttcacGgtcatggcccgcgaccgcgg	14	15	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr4:30724196G>T	uc003gsk.1	+	1	2160	c.1152G>T	c.(1150-1152)ACG>ACT	p.T384T	PCDH7_uc011bxw.1_Silent_p.T337T|PCDH7_uc011bxx.1_Silent_p.T384T	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	384	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						TGCGCTTCACGGTCATGGCCC	0.652													T	30724196	T	T	30724196	2	4	132	1	0	0	0	0	0	0	0	1	11516	1103	39	5		5	PCDH7	4	30724196	Silent	SNP	G	TCGA-14-0813-01A-01W-0424-08	20939690	30724196	160430080	33	9071											
OCIAD1	54940	broad.mit.edu	37	chr4	48852092	48852092	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacaagcacgacgatcttcaCcacctgggtaggccagattc	10	13	2	1	rs150423557		TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr4:48852092C>T	uc003gyo.2	+	6	627	c.370C>T	c.(370-372)CCA>TCA	p.P124S	OCIAD1_uc011bzk.1_RNA|OCIAD1_uc003gyr.2_Missense_Mutation_p.P124S|OCIAD1_uc003gyp.2_Missense_Mutation_p.P124S|OCIAD1_uc003gys.2_Missense_Mutation_p.P124S|OCIAD1_uc003gyq.2_Missense_Mutation_p.P124S|OCIAD1_uc010igk.2_Missense_Mutation_p.P129S	NM_017830	NP_060300	Q9NX40	OCAD1_HUMAN	OCIA domain containing 1 isoform 1	124						endosome	protein binding				0						ACGATCTTCACCACCTGGGTA	0.373													T	48852092	T	T	48852092	3	4	132	1	0	0	0	0	1	0	0	0	10817	507	18	3	407	3	OCIAD1	4	48852092	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	18127896	48852092	142302184	34	9072											
MOBKL1A	92597	broad.mit.edu	37	chr4	71847741	71847741	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaacttgcaccactccaagaActgattgaaaaactcacctc	5	13	1	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr4:71847741A>G	uc003hfw.2	+	6	808	c.618A>G	c.(616-618)GAA>GAG	p.E206E	MOBKL1A_uc011cba.1_Silent_p.E211E	NM_173468	NP_775739	Q7L9L4	MOL1A_HUMAN	MOB1, Mps One Binder kinase activator-like 1A	206					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			CACTCCAAGAACTGATTGAAA	0.353													G	71847741	G	G	71847741	2	3	132	1	0	0	0	0	0	0	0	1	9682	40	2	4		4	MOBKL1A	4	71847741	Silent	SNP	A	TCGA-14-0813-01A-01W-0424-08	22995649	71847741	119306535	35	9073											
SLC39A8	64116	broad.mit.edu	37	chr4	103184237	103184237	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tctcctgcatacaaggtaatGagtagaatggctgtgaatcc	10	8	1	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr4:103184237G>A	uc003hwb.1	-	8	1876	c.1347C>T	c.(1345-1347)CTC>CTT	p.L449L	SLC39A8_uc011ceo.1_Intron|SLC39A8_uc003hwa.1_Silent_p.L382L|SLC39A8_uc003hwc.2_Silent_p.L449L	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),	449	Helical; (Potential).					integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		ACAAGGTAATGAGTAGAATGG	0.348													A	103184237	A	A	103184237	2	1	132	1	0	0	0	0	0	0	0	1	14624	1277	45	3		3	SLC39A8	4	103184237	Silent	SNP	G	TCGA-14-0813-01A-01W-0424-08	31336496	103184237	87970039	36	9074											
TET2	54790	broad.mit.edu	37	chr4	106158045	106158045	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cagatgcacaggccaattaaGgtggaacctggatgcaagcc	12	10	0	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr4:106158045G>C	uc003hxk.2	+	3	3332	c.2946G>C	c.(2944-2946)AAG>AAC	p.K982N	TET2_uc011cez.1_Missense_Mutation_p.K1003N|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.K982N|TET2_uc003hxi.1_Missense_Mutation_p.K982N	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	982					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		GGCCAATTAAGGTGGAACCTG	0.473			Mis N|F		MDS								C	106158045	C	C	106158045	3	2	132	1	0	0	0	0	1	0	0	0	15767	991	35	5	2948	5	TET2	4	106158045	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	2973808	106158045	84996231	37	9075											
EGF	1950	broad.mit.edu	37	chr4	110880565	110880565	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgtgtgcagagggatacgcCctaagtcgagaccggaagta	14	8	0	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr4:110880565C>A	uc003hzy.3	+	6	1490	c.1038C>A	c.(1036-1038)GCC>GCA	p.A346A	EGF_uc011cfu.1_Intron|EGF_uc011cfv.1_Silent_p.A346A	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	346	EGF-like 1.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	AGGGATACGCCCTAAGTCGAG	0.502													A	110880565	A	A	110880565	2	1	132	1	0	0	0	0	0	0	0	1	4962	610	22	5		5	EGF	4	110880565	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	4722520	110880565	80273711	38	9076											
TBC1D9	23158	broad.mit.edu	37	chr4	141578365	141578365	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agtgtgctgtctttattggtCacactgtctaaatacctgga	9	8	3	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr4:141578365C>T	uc010ioj.2	-	13	2495	c.2223G>A	c.(2221-2223)GTG>GTA	p.V741V		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	741						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CTTTATTGGTCACACTGTCTA	0.438													T	141578365	T	T	141578365	2	4	132	1	0	0	0	0	0	0	0	1	15624	813	29	3		3	TBC1D9	4	141578365	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	30697800	141578365	49575911	39	9077											
PCDHB5	26167	broad.mit.edu	37	chr5	140517019	140517019	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtggacggcttctcccagcCctacctgccgctgccggagg	14	16	1	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr5:140517019C>T	uc003liq.2	+	1	2220	c.2003C>T	c.(2002-2004)CCC>CTC	p.P668L		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	668	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCTCCCAGCCCTACCTGCCG	0.701													T	140517019	T	T	140517019	3	4	132	1	0	0	0	0	1	0	0	0	11545	623	22	3	2005	3	PCDHB5	5	140517019	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08		140517019	40398241	40	9078											
C5orf25	375484	broad.mit.edu	37	chr5	175717198	175717198	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggccttgccgtgccccctgcGacctttgccatgcccaccga	10	19	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr5:175717198G>A	uc003mds.3	+	4	1021	c.614G>A	c.(613-615)CGA>CAA	p.R205Q	C5orf25_uc003mdt.3_Intron|C5orf25_uc003mdr.3_Intron|C5orf25_uc011dfk.1_Missense_Mutation_p.R224Q|uc003mdu.1_Missense_Mutation_p.R116Q			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	205	Pro-rich.										0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		TGCCCCCTGCGACCTTTGCCA	0.512													A	175717198	A	A	175717198	3	1	132	1	0	0	0	0	1	0	0	0	2288	1073	37	2		2	C5orf25	5	175717198	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	35200179	175717198	5198062	41	9079											
HK3	3101	broad.mit.edu	37	chr5	176311062	176311062	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctgcgagtgatggcttccCgcaacagactcacgacatct	10	13	3	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr5:176311062C>T	uc003mfa.2	-	14	2023	c.1931G>A	c.(1930-1932)CGG>CAG	p.R644Q	HK3_uc003mez.2_Missense_Mutation_p.R200Q	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	644	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity	p.R644W(1)		ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGGCTTCCCGCAACAGACT	0.587													T	176311062	T	T	176311062	3	4	132	1	0	0	0	0	1	0	0	0	7192	652	23	2	864	2	HK3	5	176311062	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	593864	176311062	4604198	42	9080											
DSP	1832	broad.mit.edu	37	chr6	7585169	7585169	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctcagcctcactcaatttgcTgacatgatctccttgaaaaa	5	12	4	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:7585169T>A	uc003mxp.1	+	24	7953	c.7674T>A	c.(7672-7674)GCT>GCA	p.A2558A	DSP_uc003mxq.1_Silent_p.A1959A	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2558	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTCAATTTGCTGACATGATCT	0.478													A	7585169	A	A	7585169	2	1	132	1	0	0	0	0	0	0	0	1	4781	1567	55	5		5	DSP	6	7585169	Silent	SNP	T	TCGA-14-0813-01A-01W-0424-08		7585169	163529898	43	9081											
TULP1	7287	broad.mit.edu	37	chr6	35480607	35480607	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acctgtcagaggcccacaccTctcggagggtttcatcccgc	10	16	3	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:35480607T>C	uc003okv.3	-	1	41	c.29A>G	c.(28-30)GAG>GGG	p.E10G	TULP1_uc003okw.3_Missense_Mutation_p.E10G	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	10					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						GGCCCACACCTCTCGGAGGGT	0.522													C	35480607	C	C	35480607	3	2	132	1	0	0	0	0	1	0	0	0	16770	1551	54	4	1659	4	TULP1	6	35480607	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	27895438	35480607	135634460	44	9082											
TCTE1	202500	broad.mit.edu	37	chr6	44255398	44255398	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcatccgacggatattggcCctgggatgtgggttcctgga	15	10	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:44255398C>T	uc003oxi.2	-	2	321	c.165G>A	c.(163-165)AGG>AGA	p.R55R	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	55										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGATATTGGCCCTGGGATGTG	0.547													T	44255398	T	T	44255398	2	4	132	1	0	0	0	0	0	0	0	1	15714	622	22	3		3	TCTE1	6	44255398	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	8774791	44255398	126859669	45	9083											
C6orf138	442213	broad.mit.edu	37	chr6	47846160	47846160	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggaaggggggaaaaacgttAggaacacaggtaaaataaca	13	4	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:47846160A>G	uc011dwm.1	-	3	2454	c.2369T>C	c.(2368-2370)CTA>CCA	p.L790P	C6orf138_uc011dwn.1_Missense_Mutation_p.L554P	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	807	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						GAAAAACGTTAGGAACACAGG	0.443													G	47846160	G	G	47846160	3	3	132	1	0	0	0	0	1	0	0	0	2332	420	15	4	124	4	C6orf138	6	47846160	Missense_Mutation	SNP	A	TCGA-14-0813-01A-01W-0424-08	3590762	47846160	123268907	46	9084											
C6orf142	90523	broad.mit.edu	37	chr6	53986287	53986287	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccaaacctctgatcttcacaTttgtccccactgtcagaaga	5	14	4	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:53986287T>A	uc003pcg.3	+	2	219	c.106T>A	c.(106-108)TTT>ATT	p.F36I	C6orf142_uc003pcf.2_Missense_Mutation_p.F36I|C6orf142_uc003pch.3_Intron|C6orf142_uc011dwz.1_Intron|C6orf142_uc011dxa.1_Missense_Mutation_p.F47I	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	36	Interaction with LMNA.					nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					GATCTTCACATTTGTCCCCAC	0.413													A	53986287	A	A	53986287	3	1	132	1	0	0	0	0	1	0	0	0	2333	1493	52	5	112	5	C6orf142	6	53986287	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	6140127	53986287	117128780	47	9085											
LMBRD1	55788	broad.mit.edu	37	chr6	70411373	70411373	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aagcatattcagtggattacTcaggttagctccaaaaatta	7	7	2	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:70411373T>A	uc003pfa.2	-	11	1160	c.1045A>T	c.(1045-1047)AGT>TGT	p.S349C	LMBRD1_uc003pey.2_Missense_Mutation_p.S145C|LMBRD1_uc003pez.2_Missense_Mutation_p.S276C|LMBRD1_uc010kal.2_Missense_Mutation_p.S276C|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	349	Extracellular (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						AGTGGATTACTCAGGTTAGCT	0.294													A	70411373	A	A	70411373	3	1	132	1	0	0	0	0	1	0	0	0	8842	1551	54	5	601	5	LMBRD1	6	70411373	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	16425086	70411373	100703694	48	9086											
SIM1	6492	broad.mit.edu	37	chr6	100838922	100838922	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctgattcactggccgacccaGggtctggagaactgaccaca	11	13	2	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:100838922G>C	uc003pqj.3	-	11	1823	c.1616C>G	c.(1615-1617)CCT>CGT	p.P539R	SIM1_uc010kcu.2_Missense_Mutation_p.P539R	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	539	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GGCCGACCCAGGGTCTGGAGA	0.433													C	100838922	C	C	100838922	3	2	132	1	0	0	0	0	1	0	0	0	14323	1000	35	5	688	5	SIM1	6	100838922	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	30427549	100838922	70276145	49	9087											
AIM1	202	broad.mit.edu	37	chr6	106968654	106968654	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatccaaactgagacccaaaCgtgcatctgctgaacagagc	8	12	1	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:106968654C>T	uc003prh.2	+	2	2834	c.2347C>T	c.(2347-2349)CGT>TGT	p.R783C		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	783							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		GAGACCCAAACGTGCATCTGC	0.468													T	106968654	T	T	106968654	3	4	132	1	0	0	0	0	1	0	0	0	430	536	19	1	2353	1	AIM1	6	106968654	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	6129732	106968654	64146413	50	9088											
AKD1	221264	broad.mit.edu	37	chr6	109993127	109993127	+	Frame_Shift_Del	DEL	T	-	-													ttaaaataaacataccaaagTgacagacttctggggagttg							TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:109993127delT	uc003ptn.2	-	5	403	c.326delA	c.(325-327)CACfs	p.H109fs	AKD1_uc003ptr.3_Frame_Shift_Del_p.H109fs|AKD1_uc003pts.1_RNA	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	109					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						CATACCAAAGTGACAGACTTC	0.383													-	109993127	-	-	109993127	7	5	132	1	0	1	0	1	0	0	0	0	460	1696	59	0	5569	0	AKD1	6	109993127	Frame_Shift_Del	DEL	T	TCGA-14-0813-01A-01W-0424-08	3024473	109993127	61121940	51	9089											
RFX6	222546	broad.mit.edu	37	chr6	117203548	117203548	+	Frame_Shift_Del	DEL	C	-	-													agacaattcgccagaagtttCccctcctaacaacaaggcgg							TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr6:117203548delC	uc003pxm.2	+	4	586	c.523delC	c.(523-525)CCCfs	p.P175fs		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	175	RFX-type winged-helix.				glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						CCAGAAGTTTCCCCTCCTAAC	0.413													-	117203548	-	-	117203548	7	5	132	1	0	1	0	1	0	0	0	0	13267	855	30	0	537	0	RFX6	6	117203548	Frame_Shift_Del	DEL	C	TCGA-14-0813-01A-01W-0424-08	7210421	117203548	53911519	52	9090											
HOXA9	3205	broad.mit.edu	37	chr7	27204781	27204781	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccgtccggcgccgccgccGccacgggcgcctgggggtgc	18	18	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr7:27204781G>A	uc003syt.2	-	1	369	c.296C>T	c.(295-297)GCG>GTG	p.A99V		NM_152739	NP_689952	P31269	HXA9_HUMAN	homeobox A9	99							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)	2						CGCCGCCGCCGCCACGGGCGC	0.721			T	NUP98|MSI2	AML*								A	27204781	A	A	27204781	3	1	132	1	0	0	0	0	1	0	0	0	7298	1087	38	1	530	1	HOXA9	7	27204781	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08		27204781	131933882	53	9091											
OGDH	4967	broad.mit.edu	37	chr7	44714133	44714133	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgagaatggcgtggactaCgtgatcatgggcatgccaca	14	8	1	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr7:44714133C>T	uc003tln.2	+	7	1021	c.912C>T	c.(910-912)TAC>TAT	p.Y304Y	OGDH_uc003tlm.2_Silent_p.Y304Y|OGDH_uc011kbx.1_Silent_p.Y300Y|OGDH_uc011kby.1_Silent_p.Y154Y|OGDH_uc003tlp.2_Silent_p.Y315Y|OGDH_uc011kbz.1_Silent_p.Y99Y|OGDH_uc003tlo.1_Silent_p.Y137Y	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	304					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GCGTGGACTACGTGATCATGG	0.562													T	44714133	T	T	44714133	2	4	132	1	0	0	0	0	0	0	0	1	10839	547	19	1		1	OGDH	7	44714133	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	17509352	44714133	114424530	54	9092											
EGFR	1956	broad.mit.edu	37	chr7	55233037	55233037	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccactgcgtcaagacctgccCggcaggagtcatgggagaaa	13	12	2	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr7:55233037C>T	uc003tqk.2	+	15	2033	c.1787C>T	c.(1786-1788)CCG>CTG	p.P596L	EGFR_uc003tqi.2_Missense_Mutation_p.P596L|EGFR_uc003tqj.2_Missense_Mutation_p.P596L|EGFR_uc010kzg.1_Missense_Mutation_p.P551L|EGFR_uc011kco.1_Missense_Mutation_p.P543L|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	596	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.P596L(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAGACCTGCCCGGCAGGAGTC	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233037	T	T	55233037	3	4	132	1	0	0	0	0	1	0	0	0	4967	652	23	2	1856	2	EGFR	7	55233037	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	10518904	55233037	103905626	55	9093											
NPTX2	4885	broad.mit.edu	37	chr7	98254345	98254345	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgagctgtacgccttcaccaTctgcctgtggctgcggtcca	11	14	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr7:98254345T>A	uc003upl.2	+	3	932	c.755T>A	c.(754-756)ATC>AAC	p.I252N		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	252	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GCCTTCACCATCTGCCTGTGG	0.592													A	98254345	A	A	98254345	3	1	132	1	0	0	0	0	1	0	0	0	10603	1435	50	5	765	5	NPTX2	7	98254345	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	43021308	98254345	60884318	56	9094											
LAMB4	22798	broad.mit.edu	37	chr7	107706294	107706294	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaaatactgattgcttgaggGatcatctggacacaggcaag	11	7	2	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr7:107706294G>A	uc010ljo.1	-	21	2833	c.2749C>T	c.(2749-2751)CCC>TCC	p.P917S	LAMB4_uc003vey.2_Missense_Mutation_p.P917S|LAMB4_uc010ljp.1_5'Flank	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	917	Laminin EGF-like 9.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TTGCTTGAGGGATCATCTGGA	0.428													A	107706294	A	A	107706294	3	1	132	1	0	0	0	0	1	0	0	0	8613	1174	41	3	2592	3	LAMB4	7	107706294	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	9451949	107706294	51432369	57	9095											
MET	4233	broad.mit.edu	37	chr7	116398608	116398608	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgacttagccaaccgagagaCaagcatcttcagttaccgtg	9	11	2	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr7:116398608C>A	uc003vij.2	+	9	2385	c.2198C>A	c.(2197-2199)ACA>AAA	p.T733K	MET_uc010lkh.2_Missense_Mutation_p.T733K|MET_uc011kng.1_Missense_Mutation_p.T733K|MET_uc011knh.1_Missense_Mutation_p.T733K|MET_uc011kni.1_Missense_Mutation_p.T733K|MET_uc011knj.1_Missense_Mutation_p.T303K	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	733	Extracellular (Potential).|IPT/TIG 2.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AACCGAGAGACAAGCATCTTC	0.368			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				A	116398608	A	A	116398608	3	1	132	1	0	0	0	0	1	0	0	0	9485	478	17	5	2228	5	MET	7	116398608	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	8692314	116398608	42740055	58	9096											
MSR1	4481	broad.mit.edu	37	chr8	16021738	16021738	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgatacattgtaaacaCgctcctctaatttactgatt	5	10	1	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr8:16021738C>T	uc003wwz.2	-	5	851	c.653G>A	c.(652-654)CGT>CAT	p.R218H	MSR1_uc010lsu.2_Missense_Mutation_p.R236H|MSR1_uc003wxa.2_Missense_Mutation_p.R218H|MSR1_uc003wxb.2_Missense_Mutation_p.R218H|MSR1_uc011kxz.1_Translation_Start_Site	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	218	Potential.|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATTGTAAACACGCTCCTCTAA	0.338													T	16021738	T	T	16021738	3	4	132	1	0	0	0	0	1	0	0	0	9886	536	19	1	774	1	MSR1	8	16021738	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08		16021738	130342284	59	9097											
ZNF395	55893	broad.mit.edu	37	chr8	28210755	28210755	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atcggtctcaaagccatgatCagtttggggagaaccaaaag	11	8	2	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr8:28210755C>T	uc003xgq.2	-	5	842	c.754G>A	c.(754-756)GAT>AAT	p.D252N	ZNF395_uc003xgt.2_Missense_Mutation_p.D252N|ZNF395_uc003xgr.2_Missense_Mutation_p.D252N|ZNF395_uc003xgs.2_Missense_Mutation_p.D252N	NM_018660	NP_061130	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	252					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		AAGCCATGATCAGTTTGGGGA	0.592													T	28210755	T	T	28210755	3	4	132	1	0	0	0	0	1	0	0	0	17878	826	29	3	811	3	ZNF395	8	28210755	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	12189017	28210755	118153267	60	9098											
FER1L6	654463	broad.mit.edu	37	chr8	125110059	125110059	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgaccatctggaacactgaAgatgtcattttagaggatga	11	6	2	5			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr8:125110059A>G	uc003yqw.2	+	37	5024	c.4818A>G	c.(4816-4818)GAA>GAG	p.E1606E	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1606	C2 6.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GGAACACTGAAGATGTCATTT	0.423													G	125110059	G	G	125110059	2	3	132	1	0	0	0	0	0	0	0	1	5815	69	3	4		4	FER1L6	8	125110059	Silent	SNP	A	TCGA-14-0813-01A-01W-0424-08	96899304	125110059	21253963	61	9099											
NFIB	4781	broad.mit.edu	37	chr9	14155894	14155894	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaactatcctcaaggtaaccTgaaaataaatattaaaggaa	5	6	1	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr9:14155894T>A	uc003zle.2	-	4	1052	c.617_splice	c.e4-1	p.G206_splice	NFIB_uc003zld.2_Splice_Site|NFIB_uc003zlf.2_Splice_Site_p.G206_splice|NFIB_uc011lmo.1_Splice_Site_p.G206_splice	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B						anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		CAAGGTAACCTGAAAATAAAT	0.274			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								A	14155894	A	A	14155894	5	1	132	1	0	0	0	0	0	0	1	0	10371	1594	55	5	671	5	NFIB	9	14155894	Splice_Site	SNP	T	TCGA-14-0813-01A-01W-0424-08		14155894	127057537	62	9100											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18777209	18777209	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccgaaggaggccctgcagacCcacaaacaccagaacgggat	11	14	0	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr9:18777209C>G	uc003zne.3	+	19	3109	c.2982C>G	c.(2980-2982)ACC>ACG	p.T994T		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	994						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CCCTGCAGACCCACAAACACC	0.687													G	18777209	G	G	18777209	2	3	132	1	0	0	0	0	0	0	0	1	274	610	22	5		5	ADAMTSL1	9	18777209	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	4621315	18777209	122436222	63	9101											
FAM108B1	51104	broad.mit.edu	37	chr9	74485080	74485080	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagtcagaggagaatgaagaAtaacagcagcactctcatat	9	7	2	4			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr9:74485080A>G	uc004aim.1	-	3	1168	c.566T>C	c.(565-567)ATT>ACT	p.I189T	FAM108B1_uc004ail.2_Missense_Mutation_p.I189T	NM_001025780	NP_001020951	Q5VST6	F108B_HUMAN	family with sequence similarity 108, member B1	189						extracellular region	hydrolase activity				0						AGAATGAAGAATAACAGCAGC	0.423													G	74485080	G	G	74485080	3	3	132	1	0	0	0	0	1	0	0	0	5392	101	4	4	339	4	FAM108B1	9	74485080	Missense_Mutation	SNP	A	TCGA-14-0813-01A-01W-0424-08	55707871	74485080	66728351	64	9102											
TMC1	117531	broad.mit.edu	37	chr9	75406910	75406910	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttgaaatggctactgggaCgcatttttgctcttctttta	8	8	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr9:75406910C>T	uc004aiz.1	+	16	1873	c.1333C>T	c.(1333-1335)CGC>TGC	p.R445C	TMC1_uc010moz.1_Missense_Mutation_p.R403C|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.R299C|TMC1_uc010mpa.1_Missense_Mutation_p.R299C	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	445	Helical; (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						GCTACTGGGACGCATTTTTGC	0.393													T	75406910	T	T	75406910	3	4	132	1	0	0	0	0	1	0	0	0	15981	536	19	1	1379	1	TMC1	9	75406910	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	921830	75406910	65806521	65	9103											
GRIN3A	116443	broad.mit.edu	37	chr9	104432454	104432454	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tacagaaaatggcccaaaggTtcattagaaaccttccagtc	7	10	1	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr9:104432454T>G	uc004bbp.1	-	3	2841	c.2240A>C	c.(2239-2241)AAC>ACC	p.N747T	GRIN3A_uc004bbq.1_Missense_Mutation_p.N747T	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	747	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GGCCCAAAGGTTCATTAGAAA	0.433													G	104432454	G	G	104432454	3	3	132	1	0	0	0	0	1	0	0	0	6783	1725	60	5	1135	5	GRIN3A	9	104432454	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	29025544	104432454	36780977	66	9104											
MUSK	4593	broad.mit.edu	37	chr9	113445003	113445003	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtggatgccttagttgaagaAgtggctactttcatgtgtgc	13	6	1	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr9:113445003A>T	uc004bey.2	+	2	227	c.129A>T	c.(127-129)GAA>GAT	p.E43D	MUSK_uc004bex.2_Missense_Mutation_p.E43D	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	43	Ig-like 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						TAGTTGAAGAAGTGGCTACTT	0.378													T	113445003	T	T	113445003	3	4	132	1	0	0	0	0	1	0	0	0	9989	69	3	5	135	5	MUSK	9	113445003	Missense_Mutation	SNP	A	TCGA-14-0813-01A-01W-0424-08	9012549	113445003	27768428	67	9105											
GDF2	2658	broad.mit.edu	37	chr10	48413956	48413956	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgcagccacgtggccatcCgtgtcctcctcgtgactgct	10	18	0	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr10:48413956C>T	uc001jfa.1	-	2	1075	c.912G>A	c.(910-912)ACG>ACA	p.T304T		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	304					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						CGTGGCCATCCGTGTCCTCCT	0.607													T	48413956	T	T	48413956	2	4	132	1	0	0	0	0	0	0	0	1	6314	639	23	2		2	GDF2	10	48413956	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08		48413956	87120791	68	9106											
A1CF	29974	broad.mit.edu	37	chr10	52566580	52566580	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgctaagtcttgtccaaggGttaccgcttgcttgagctgg	12	10	1	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr10:52566580G>T	uc001jjj.2	-	13	1882	c.1694C>A	c.(1693-1695)ACC>AAC	p.T565N	A1CF_uc010qhn.1_Missense_Mutation_p.T565N|A1CF_uc001jji.2_Missense_Mutation_p.T557N|A1CF_uc001jjh.2_Missense_Mutation_p.T565N|A1CF_uc010qho.1_Missense_Mutation_p.T573N|A1CF_uc009xov.2_Missense_Mutation_p.T557N	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	565					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						TTGTCCAAGGGTTACCGCTTG	0.493													T	52566580	T	T	52566580	3	4	132	1	0	0	0	0	1	0	0	0	2	1261	44	5	94	5	A1CF	10	52566580	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	4152624	52566580	82968167	69	9107											
PTEN	5728	broad.mit.edu	37	chr10	89692883	89692883	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	acaatcatgttgcagcaattCactgtaaagctggaaaggga	10	7	2	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr10:89692883C>T	uc001kfb.2	+	6	1398	c.367C>T	c.(367-369)CAC>TAC	p.H123Y		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	123	Phosphatase tensin-type.		H -> R (in CD).|H -> Y (in endometrial cancer; loss of protein phosphatase activity).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.H123Y(4)|p.R55fs*1(4)|p.I122fs*2(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.A121_F145del(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGCAGCAATTCACTGTAAAGC	0.398		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89692883	T	T	89692883	3	4	132	1	0	0	0	0	1	0	0	0	12738	826	29	3	385	3	PTEN	10	89692883	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	37126303	89692883	45841864	70	9108											
FAM178A	55719	broad.mit.edu	37	chr10	102676871	102676871	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagttgtcactagcttcttaCtgcagagaacgagaactaaa	8	9	2	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr10:102676871C>T	uc001krt.3	+	3	1271	c.729C>T	c.(727-729)TAC>TAT	p.Y243Y	FAM178A_uc001krr.1_Silent_p.Y243Y|FAM178A_uc001krs.2_Silent_p.Y243Y|FAM178A_uc001kru.1_Silent_p.Y179Y	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	243											0						TAGCTTCTTACTGCAGAGAAC	0.473													T	102676871	T	T	102676871	2	4	132	1	0	0	0	0	0	0	0	1	5503	576	20	3		3	FAM178A	10	102676871	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	12983988	102676871	32857876	71	9109											
PCGF6	84108	broad.mit.edu	37	chr10	105108477	105108477	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatatattcttcttaccttaTgttataaagaggttgtgtct	6	5	3	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr10:105108477T>C	uc001kwt.2	-	3	621	c.553A>G	c.(553-555)ATA>GTA	p.I185V	PCGF6_uc001kwu.2_Missense_Mutation_p.I185V|PCGF6_uc009xxk.2_RNA|PCGF6_uc009xxl.2_RNA|PCGF6_uc009xxm.2_RNA	NM_001011663	NP_001011663	Q9BYE7	PCGF6_HUMAN	polycomb group ring finger 6 isoform a	185					negative regulation of transcription, DNA-dependent	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)	1		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;2.57e-09)|all cancers(201;7.21e-08)|BRCA - Breast invasive adenocarcinoma(275;0.205)		TCTTACCTTATGTTATAAAGA	0.284													C	105108477	C	C	105108477	3	2	132	1	0	0	0	0	1	0	0	0	11578	1464	51	4	531	4	PCGF6	10	105108477	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	2431606	105108477	30426270	72	9110											
OR56B4	196335	broad.mit.edu	37	chr11	6129052	6129052	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctatgactccagcctccagaTttcccagttcatcctgatgg	7	14	1	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr11:6129052T>A	uc010qzx.1	+	1	44	c.44T>A	c.(43-45)ATT>AAT	p.I15N		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCCTCCAGATTTCCCAGTTC	0.493													A	6129052	A	A	6129052	3	1	132	1	0	0	0	0	1	0	0	0	11138	1493	52	5	46	5	OR56B4	11	6129052	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08		6129052	128877464	73	9111											
QSER1	79832	broad.mit.edu	37	chr11	32954286	32954286	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggtttataggtccagcaaGgttgagaaattgccaccctt	10	9	0	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr11:32954286G>A	uc001mty.2	+	4	1362	c.1095G>A	c.(1093-1095)AAG>AAA	p.K365K	QSER1_uc001mtz.1_Intron|QSER1_uc001mua.2_5'Flank	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	365	Ser-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					GGTCCAGCAAGGTTGAGAAAT	0.383													A	32954286	A	A	32954286	2	1	132	1	0	0	0	0	0	0	0	1	12882	991	35	3		3	QSER1	11	32954286	Silent	SNP	G	TCGA-14-0813-01A-01W-0424-08	26825234	32954286	102052230	74	9112											
OR5AR1	219493	broad.mit.edu	37	chr11	56431526	56431526	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcagccatggcctatggtcGttttgtggccatttgtcgac	13	10	0	0	rs143043362		TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr11:56431526G>A	uc010rjm.1	+	1	365	c.365G>A	c.(364-366)CGT>CAT	p.R122H		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCTATGGTCGTTTTGTGGCC	0.512													A	56431526	A	A	56431526	3	1	132	1	0	0	0	0	1	0	0	0	11145	1145	40	1	367	1	OR5AR1	11	56431526	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	23477240	56431526	78574990	75	9113											
PLAC1L	219990	broad.mit.edu	37	chr11	59807826	59807826	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacccaaataaggaggaaaaCgaacgcagctgagcatggga	12	8	0	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr11:59807826C>T	uc001nol.2	+	1	79	c.-106C>T	c.(-108--104)AACGA>AATGA			NM_173801	NP_776162	Q86WS3	PLACL_HUMAN	placenta-specific 1-like precursor							extracellular region				ovary(2)|skin(1)	3						AGGAGGAAAACGAACGCAGCT	0.463													T	59807826	T	T	59807826	1	4	132	1	0	0	0	0	0	0	0	0	12013	551	19	1		1	PLAC1L	11	59807826	Translation_Start_Site	SNP	C	TCGA-14-0813-01A-01W-0424-08	3376300	59807826	75198690	76	9114											
MS4A14	84689	broad.mit.edu	37	chr11	60183888	60183888	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aactccatagaagaaaatccTcaagacggcattccttaaac	5	11	1	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr11:60183888T>A	uc001npj.2	+	5	2012	c.1447T>A	c.(1447-1449)TCA>ACA	p.S483T	MS4A14_uc001npi.2_Missense_Mutation_p.S371T|MS4A14_uc001npn.2_Missense_Mutation_p.S221T|MS4A14_uc001npk.2_Missense_Mutation_p.S466T|MS4A14_uc001npl.2_Missense_Mutation_p.S221T|MS4A14_uc001npm.2_Missense_Mutation_p.S221T	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	483	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						AAGAAAATCCTCAAGACGGCA	0.398													A	60183888	A	A	60183888	3	1	132	1	0	0	0	0	1	0	0	0	9858	1551	54	5	1465	5	MS4A14	11	60183888	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	376062	60183888	74822628	77	9115											
AHNAK	79026	broad.mit.edu	37	chr11	62285625	62285625	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtggccccttggcattgaCgtgcaagtcggaccccggag	14	13	0	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr11:62285625C>T	uc001ntl.2	-	5	16564	c.16264G>A	c.(16264-16266)GTC>ATC	p.V5422I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5422					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTGGCATTGACGTGCAAGTCG	0.532													T	62285625	T	T	62285625	3	4	132	1	0	0	0	0	1	0	0	0	414	536	19	1	1528	1	AHNAK	11	62285625	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	2101737	62285625	72720891	78	9116											
RBM4	5936	broad.mit.edu	37	chr11	66411364	66411384	+	In_Frame_Del	DEL	GCTGCTGCTGCAGCAGCAGCC	-	-													cctcaggagctgctgccacaGctgctgctgcagcagcagcc							TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr11:66411364_66411384delGCTGCTGCTGCAGCAGCAGCC	uc009yrj.2	+	3	1344_1364	c.856_876delGCTGCTGCTGCAGCAGCAGCC	c.(856-876)GCTGCTGCTGCAGCAGCAGCCdel	p.AAAAAAA286del	RBM4_uc009yrk.2_In_Frame_Del_p.AAAAAAA261del|RBM4_uc001oiw.1_In_Frame_Del_p.AAAAAAA286del|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_In_Frame_Del_p.AAAAAAA286del|RBM4_uc001oiz.1_In_Frame_Del_p.AAAAAAA286del	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	286_292	Interaction with TNPO3.|Poly-Ala.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		tgctgccacagctgctgctgcagcagcagccgctgctgctg	0.457													-	66411384	-	-	66411364	7	5	132	1	0	1	0	1	0	0	0	0	13134	971	34	0	862	0	RBM4	11	66411364	In_Frame_Del	DEL	GCTGCTGCTGCAGCAGCAGCC	TCGA-14-0813-01A-01W-0424-08	4125739	66411364	68595152	79	9117											
DHH	50846	broad.mit.edu	37	chr12	49483743	49483743	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcagcgcccctagcgcgtGcagcagtctcaagggggcaa	15	13	1	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr12:49483743G>A	uc001rtf.2	-	3	1397	c.1090C>T	c.(1090-1092)CAC>TAC	p.H364Y		NM_021044	NP_066382	O43323	DHH_HUMAN	desert hedgehog preproprotein	364					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			lung(1)|breast(1)	2						CCTAGCGCGTGCAGCAGTCTC	0.667													A	49483743	A	A	49483743	3	1	132	1	0	0	0	0	1	0	0	0	4483	1319	46	3	104	3	DHH	12	49483743	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08		49483743	84368152	80	9118											
ACVRL1	94	broad.mit.edu	37	chr12	52312886	52312887	+	Missense_Mutation	DNP	TG	GT	GT													ccccaccatccctaaccggcTggctgcagacccggtgaggc							TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr12:52312886_52312887TG>GT	uc001rzj.2	+	9	1647_1648	c.1364_1365TG>GT	c.(1363-1365)CTG>CGT	p.L455R	ACVRL1_uc001rzk.2_Missense_Mutation_p.L455R|ACVRL1_uc010snm.1_Missense_Mutation_p.L281R	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	455	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CCTAACCGGCTGGCTGCAGACC	0.599									Hereditary_Hemorrhagic_Telangiectasia				GT	52312887	GT	GT	52312886	3	3	132	1	0	0	0	0	1	0	0	0	225	1580	55	5	1394	5	ACVRL1	12	52312886	Missense_Mutation	DNP	TG	TCGA-14-0813-01A-01W-0424-08	2829143	52312886	81539009	81	9119											
TPCN1	53373	broad.mit.edu	37	chr12	113730818	113730818	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gagctctaccgggaggcacgGggggcctcctcggatgtcac	16	13	2	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr12:113730818G>C	uc001tuw.2	+	26	2490	c.2193G>C	c.(2191-2193)CGG>CGC	p.R731R	TPCN1_uc001tux.2_Silent_p.R803R|TPCN1_uc010syu.1_5'Flank	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	731	Cytoplasmic (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						GGGAGGCACGGGGGGCCTCCT	0.617													C	113730818	C	C	113730818	2	2	132	1	0	0	0	0	0	0	0	1	16392	1219	43	5		5	TPCN1	12	113730818	Silent	SNP	G	TCGA-14-0813-01A-01W-0424-08	61417932	113730818	20121077	82	9120											
ORAI1	84876	broad.mit.edu	37	chr12	122079191	122079191	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccttctccaccgtcatcgGcacgctgctcttcctagctg	9	17	3	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr12:122079191G>A	uc010szz.1	+	3	741	c.548G>A	c.(547-549)GGC>GAC	p.G183D		NM_032790	NP_116179	Q96D31	CRCM1_HUMAN	calcium release-activated calcium channel	183	Helical; (Potential).				platelet activation|positive regulation of calcium ion transport	integral to plasma membrane	protein binding|store-operated calcium channel activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000415)|Epithelial(86;0.00148)		ACCGTCATCGGCACGCTGCTC	0.637													A	122079191	A	A	122079191	3	1	132	1	0	0	0	0	1	0	0	0	11257	1203	42	3	560	3	ORAI1	12	122079191	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	8348373	122079191	11772704	83	9121											
ENOX1	55068	broad.mit.edu	37	chr13	43935415	43935415	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttctcataggcgttacttacTtggattttgaggaaaaagag	10	5	1	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr13:43935415T>C	uc001uza.3	-	6	682	c.382A>G	c.(382-384)AAT>GAT	p.N128D	ENOX1_uc001uzb.3_Missense_Mutation_p.N128D|ENOX1_uc001uzc.3_Missense_Mutation_p.N128D|ENOX1_uc010tfm.1_5'Flank	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	128	Pro-rich.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		CGTTACTTACTTGGATTTTGA	0.378													C	43935415	C	C	43935415	3	2	132	1	0	0	0	0	1	0	0	0	5126	1623	56	4	1597	4	ENOX1	13	43935415	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08		43935415	71234463	84	9122											
PRKD1	5587	broad.mit.edu	37	chr14	30068325	30068325	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaaggtgccgcaaagccaCgagtatctgtaaagaagaat	11	7	1	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr14:30068325C>T	uc001wqh.2	-	15	2255	c.2074G>A	c.(2074-2076)GTG>ATG	p.V692M		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	692	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CGCAAAGCCACGAGTATCTGT	0.368													T	30068325	T	T	30068325	3	4	132	1	0	0	0	0	1	0	0	0	12518	536	19	1	680	1	PRKD1	14	30068325	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08		30068325	77281215	85	9123											
MKRN3	7681	broad.mit.edu	37	chr15	23811197	23811197	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccagtccgttgccaagcCgaagcagcggcatttggaca	13	13	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr15:23811197C>T	uc001ywh.3	+	1	744	c.268C>T	c.(268-270)CGA>TGA	p.R90*	MKRN3_uc001ywi.2_Nonsense_Mutation_p.R90*|MKRN3_uc010ayi.1_Nonsense_Mutation_p.R90*	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	90						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GTTGCCAAGCCGAAGCAGCGG	0.607													T	23811197	T	T	23811197	4	4	132	1	0	0	0	0	0	1	0	0	9608	644	23	2	270	2	MKRN3	15	23811197	Nonsense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08		23811197	78720195	86	9124											
FBN1	2200	broad.mit.edu	37	chr15	48744871	48744871	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cacactgggccgttctgacaCtcgtcaatatctacgagcag	9	13	3	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr15:48744871C>A	uc001zwx.1	-	45	5761	c.5433G>T	c.(5431-5433)GAG>GAT	p.E1811D	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1811	EGF-like 30; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CGTTCTGACACTCGTCAATAT	0.488													A	48744871	A	A	48744871	3	1	132	1	0	0	0	0	1	0	0	0	5702	564	20	5	3270	5	FBN1	15	48744871	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	24933674	48744871	53786521	87	9125											
VPS13C	54832	broad.mit.edu	37	chr15	62292774	62292774	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aatgattacctcaacttgtgCttgttgccttgctaaaatta	6	8	1	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr15:62292774C>A	uc002agz.2	-	16	1416	c.1342G>T	c.(1342-1344)GCA>TCA	p.A448S	VPS13C_uc002aha.2_Missense_Mutation_p.A405S|VPS13C_uc002ahb.1_Missense_Mutation_p.A448S|VPS13C_uc002ahc.1_Missense_Mutation_p.A405S	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	448					protein localization					ovary(2)	2						TCAACTTGTGCTTGTTGCCTT	0.308													A	62292774	A	A	62292774	3	1	132	1	0	0	0	0	1	0	0	0	17188	797	28	5	10227	5	VPS13C	15	62292774	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	13547903	62292774	40238618	88	9126											
TLN2	83660	broad.mit.edu	37	chr15	63058560	63058560	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttcggtggtccaggaaatcgGacaccttatcgatcccatcg	10	12	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr15:63058560G>A	uc002alb.3	+	38	5135	c.5135G>A	c.(5134-5136)GGA>GAA	p.G1712E	TLN2_uc002alc.3_Missense_Mutation_p.G105E|TLN2_uc002ald.2_Missense_Mutation_p.G105E	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1712					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CAGGAAATCGGACACCTTATC	0.572													A	63058560	A	A	63058560	3	1	132	1	0	0	0	0	1	0	0	0	15945	1174	41	3	5285	3	TLN2	15	63058560	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	765786	63058560	39472832	89	9127											
SH3GL3	6457	broad.mit.edu	37	chr15	84245409	84245409	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgagtaggtaagataccagaCgaagaagtcagacaagcggt	13	7	1	4	rs138675150	byFrequency	TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr15:84245409C>T	uc002bjw.2	+	6	735	c.540C>T	c.(538-540)GAC>GAT	p.D180D	SH3GL3_uc010uot.1_Silent_p.D180D|SH3GL3_uc002bjx.2_Silent_p.D111D|SH3GL3_uc002bju.2_Silent_p.D188D|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	180	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						AGATACCAGACGAAGAAGTCA	0.383													T	84245409	T	T	84245409	2	4	132	1	0	0	0	0	0	0	0	1	14252	535	19	1		1	SH3GL3	15	84245409	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	21186849	84245409	18285983	90	9128											
CHD2	1106	broad.mit.edu	37	chr15	93563361	93563361	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtacaaggaccaccattatGgggaccggcgacatatggat	13	9	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr15:93563361G>A	uc002bsp.2	+	38	5601	c.5026G>A	c.(5026-5028)GGG>AGG	p.G1676R	CHD2_uc002bso.1_Missense_Mutation_p.G1676R	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1676					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CCACCATTATGGGGACCGGCG	0.527													A	93563361	A	A	93563361	3	1	132	1	0	0	0	0	1	0	0	0	3325	1348	47	3	5176	3	CHD2	15	93563361	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	9317952	93563361	8968031	91	9129											
IL4R	3566	broad.mit.edu	37	chr16	27363945	27363945	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggatttcctacagggcaCgggtgagggcctgggctcag	17	10	1	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr16:27363945C>T	uc002don.2	+	7	840	c.598C>T	c.(598-600)CGG>TGG	p.R200W	IL4R_uc002dom.2_Missense_Mutation_p.R200W|IL4R_uc002dop.3_Missense_Mutation_p.R185W|IL4R_uc010bxy.2_Missense_Mutation_p.R200W|IL4R_uc002doo.2_Missense_Mutation_p.R40W	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	200	Extracellular (Potential).|Fibronectin type-III.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						CTACAGGGCACGGGTGAGGGC	0.552													T	27363945	T	T	27363945	3	4	132	1	0	0	0	0	1	0	0	0	7698	527	19	1	616	1	IL4R	16	27363945	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08		27363945	62990808	92	9130											
PLCG2	5336	broad.mit.edu	37	chr16	81954828	81954828	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agatataaactccctctacgAcgtcagcagaatgtatgtgg	9	9	2	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr16:81954828A>C	uc002fgt.2	+	21	2413	c.2261A>C	c.(2260-2262)GAC>GCC	p.D754A	PLCG2_uc010chg.1_Missense_Mutation_p.D754A	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	754					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TCCCTCTACGACGTCAGCAGA	0.428													C	81954828	C	C	81954828	3	2	132	1	0	0	0	0	1	0	0	0	12036	275	10	5	2339	5	PLCG2	16	81954828	Missense_Mutation	SNP	A	TCGA-14-0813-01A-01W-0424-08	54590883	81954828	8399925	93	9131											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	9	16	3	0	rs28934574		TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577094	A	A	7577094	3	1	132	1	0	0	0	0	1	0	0	0	16378	1115	39	2	442	2	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08		7577094	73618116	94	9132											
TP53	7157	broad.mit.edu	37	chr17	7578211	7578214	+	Frame_Shift_Del	DEL	CGAA	-	-													agggcaccaccacactatgtCgaaaagtgtttctgtcatcc							TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr17:7578211_7578214delCGAA	uc002gim.2	-	6	829_832	c.635_638delTTCG	c.(634-639)TTTCGAfs	p.F212fs	TP53_uc002gig.1_Frame_Shift_Del_p.F212fs|TP53_uc002gih.2_Frame_Shift_Del_p.F212fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.F80fs|TP53_uc010cng.1_Frame_Shift_Del_p.F80fs|TP53_uc002gii.1_Frame_Shift_Del_p.F80fs|TP53_uc010cnh.1_Frame_Shift_Del_p.F212fs|TP53_uc010cni.1_Frame_Shift_Del_p.F212fs|TP53_uc002gij.2_Frame_Shift_Del_p.F212fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.F119fs|TP53_uc002gio.2_Frame_Shift_Del_p.F80fs|TP53_uc010vug.1_Frame_Shift_Del_p.F173fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	212_213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.F212fs*3(7)|p.0?(7)|p.R213P(5)|p.F212L(3)|p.R213fs*34(3)|p.F212I(2)|p.R81*(2)|p.F212S(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.T211_F212insX(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.D208fs*1(1)|p.F212fs*4(1)|p.R213>L(1)|p.F212Y(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACACTATGTCGAAAAGTGTTTCT	0.534		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			-	7578214	-	-	7578211	7	5	132	1	0	1	0	1	0	0	0	0	16378	884	31	0	656	0	TP53	17	7578211	Frame_Shift_Del	DEL	CGAA	TCGA-14-0813-01A-01W-0424-08	1117	7578211	73616999	95	9133											
TRIM16	10626	broad.mit.edu	37	chr17	15517208	15517208	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtctcggtatttgctgaaCccagaagacaggtctctgat	10	9	2	4			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr17:15517208C>T	uc002gor.1	-	9	2077	c.1740G>A	c.(1738-1740)GGG>GGA	p.G580G	CDRT1_uc002gov.3_Silent_p.G270G			O95361	TRI16_HUMAN	SubName: Full=Putative uncharacterized protein; Flags: Fragment;	Error:Variant_position_missing_in_O95361_after_alignment					histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		ATTTGCTGAACCCAGAAGACA	0.488													T	15517208	T	T	15517208	2	4	132	1	0	0	0	0	0	0	0	1	16488	494	18	3		3	TRIM16	17	15517208	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	7938997	15517208	65678002	96	9134											
KPNB1	3837	broad.mit.edu	37	chr17	45734349	45734349	+	Frame_Shift_Del	DEL	A	-	-													tcattcctcagctggtggccAatgtcacaaaccccaacagc							TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr17:45734349delA	uc002ilt.1	+	4	742	c.406delA	c.(406-408)AATfs	p.N136fs	KPNB1_uc010wkw.1_5'UTR|KPNB1_uc010wkx.1_5'UTR	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	136	HEAT 1.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						GCTGGTGGCCAATGTCACAAA	0.483													-	45734349	-	-	45734349	7	5	132	1	0	1	0	1	0	0	0	0	8435	130	5	0	420	0	KPNB1	17	45734349	Frame_Shift_Del	DEL	A	TCGA-14-0813-01A-01W-0424-08	30217141	45734349	35460861	97	9135											
RBBP8	5932	broad.mit.edu	37	chr18	20573449	20573449	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaagattccccaggggagccCtgttcacaggaatgcatcat	10	11	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr18:20573449C>G	uc002ktw.2	+	11	1990	c.1659C>G	c.(1657-1659)CCC>CCG	p.P553P	RBBP8_uc002kty.2_Silent_p.P553P|RBBP8_uc002ktz.2_Silent_p.P553P|RBBP8_uc002kua.2_Silent_p.P553P|RBBP8_uc010xap.1_5'Flank|RBBP8_uc002ktx.1_Silent_p.P553P	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	553					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			CAGGGGAGCCCTGTTCACAGG	0.438								Direct_reversal_of_damage|Homologous_recombination					G	20573449	G	G	20573449	2	3	132	1	0	0	0	0	0	0	0	1	13105	668	24	5		5	RBBP8	18	20573449	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08		20573449	57503799	98	9136											
PSMA8	143471	broad.mit.edu	37	chr18	23738210	23738210	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tacttatcatgcttggaaggTgagtcatgaatttattaata	8	4	2	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr18:23738210T>A	uc002kvq.2	+	4	609	c.495_splice	c.e4+2	p.K165_splice	PSMA8_uc002kvo.2_Splice_Site_p.K121_splice|PSMA8_uc002kvp.2_Splice_Site_p.K159_splice|PSMA8_uc002kvr.2_Splice_Site_p.K133_splice	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			GCTTGGAAGGTGAGTCATGAA	0.299													A	23738210	A	A	23738210	5	1	132	1	0	0	0	0	0	0	1	0	12673	1710	59	5	511	5	PSMA8	18	23738210	Splice_Site	SNP	T	TCGA-14-0813-01A-01W-0424-08	3164761	23738210	54339038	99	9137											
SERPINB3	6317	broad.mit.edu	37	chr18	61323223	61323223	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaaccgaggtaagtgtaaatCgacacgtgtctctctcatat	9	9	2	0	rs143634391		TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr18:61323223C>T	uc002lji.2	-	8	985	c.841G>A	c.(841-843)GAT>AAT	p.D281N	SERPINB4_uc002ljg.2_Intron|SERPINB3_uc010dqa.2_Missense_Mutation_p.D229N	NM_006919	NP_008850	P29508	SPB3_HUMAN	serine (or cysteine) proteinase inhibitor, clade	281					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AAGTGTAAATCGACACGTGTC	0.418													T	61323223	T	T	61323223	3	4	132	1	0	0	0	0	1	0	0	0	14102	884	31	2	335	2	SERPINB3	18	61323223	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	37585013	61323223	16754025	100	9138											
FARSA	2193	broad.mit.edu	37	chr19	13041262	13041262	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccactcggaacacccggggcCcgtcagccgcactcttgtcc	10	19	2	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr19:13041262C>T	uc002mvs.2	-	3	413	c.365G>A	c.(364-366)GGG>GAG	p.G122E	FARSA_uc002mvt.2_RNA|FARSA_uc010xmv.1_Missense_Mutation_p.G122E|FARSA_uc010dyy.1_Intron	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	122					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)	CACCCGGGGCCCGTCAGCCGC	0.637													T	13041262	T	T	13041262	3	4	132	1	0	0	0	0	1	0	0	0	5679	623	22	3	1205	3	FARSA	19	13041262	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08		13041262	46087721	101	9139											
ZNF681	148213	broad.mit.edu	37	chr19	23927229	23927229	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaggtgtgaggactgcctaaAggctttgccacattcttcac	10	10	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr19:23927229A>C	uc002nrk.3	-	4	1265	c.1123T>G	c.(1123-1125)TTT>GTT	p.F375V	ZNF681_uc002nrl.3_Missense_Mutation_p.F306V|ZNF681_uc002nrj.3_Missense_Mutation_p.F306V	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	375	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				GACTGCCTAAAGGCTTTGCCA	0.413													C	23927229	C	C	23927229	3	2	132	1	0	0	0	0	1	0	0	0	18085	72	3	5	818	5	ZNF681	19	23927229	Missense_Mutation	SNP	A	TCGA-14-0813-01A-01W-0424-08	10885967	23927229	35201754	102	9140											
ZNF569	148266	broad.mit.edu	37	chr19	37905163	37905163	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atactcatagagattgtgtcTggaagggaaaaaatcagagt	11	4	3	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr19:37905163T>C	uc002ogi.2	-	6	955	c.397A>G	c.(397-399)AGA>GGA	p.R133G	ZNF569_uc002ogh.2_5'UTR|ZNF569_uc002ogj.2_Missense_Mutation_p.R157G	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGATTGTGTCTGGAAGGGAAA	0.323													C	37905163	C	C	37905163	3	2	132	1	0	0	0	0	1	0	0	0	17997	1588	55	4	1667	4	ZNF569	19	37905163	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	13977934	37905163	21223820	103	9141											
PRX	57716	broad.mit.edu	37	chr19	40903183	40903183	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaatcggggaaaactaaggCggggcatcttcagggccacc	13	11	2	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr19:40903183C>T	uc002onr.2	-	7	1345	c.1076G>A	c.(1075-1077)CGC>CAC	p.R359H	PRX_uc002onq.2_Missense_Mutation_p.R220H|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	359					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AAAACTAAGGCGGGGCATCTT	0.637													T	40903183	T	T	40903183	3	4	132	1	0	0	0	0	1	0	0	0	12642	768	27	1	3313	1	PRX	19	40903183	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	2998020	40903183	18225800	104	9142											
SIGLEC8	27181	broad.mit.edu	37	chr19	51960834	51960834	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taagggtgagcactgaggagCgggcagtagtggggcccggg	21	7	0	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr19:51960834C>T	uc002pwt.2	-	2	681	c.614G>A	c.(613-615)CGC>CAC	p.R205H	SIGLEC8_uc010yda.1_Intron|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Intron	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	205	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CACTGAGGAGCGGGCAGTAGT	0.652													T	51960834	T	T	51960834	3	4	132	1	0	0	0	0	1	0	0	0	14314	768	27	1	909	1	SIGLEC8	19	51960834	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	11057651	51960834	7168149	105	9143											
NLRP7	199713	broad.mit.edu	37	chr19	55451643	55451643	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccagcgtggttttccccaCgcctgcggggccgtgcagca	15	15	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr19:55451643C>T	uc002qih.3	-	4	620	c.544G>A	c.(544-546)GTG>ATG	p.V182M	NLRP7_uc002qig.3_Missense_Mutation_p.V182M|NLRP7_uc002qii.3_Missense_Mutation_p.V182M|NLRP7_uc010esk.2_Missense_Mutation_p.V182M|NLRP7_uc010esl.2_Missense_Mutation_p.V210M	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	182	NACHT.|ATP (Potential).						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GTTTTCCCCACGCCTGCGGGG	0.562													T	55451643	T	T	55451643	3	4	132	1	0	0	0	0	1	0	0	0	10482	536	19	1	2601	1	NLRP7	19	55451643	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	3490809	55451643	3677340	106	9144											
USP29	57663	broad.mit.edu	37	chr19	57641754	57641754	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aagtctctcaggagatgattTctgagatcaacagcccattg	9	9	4	3			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr19:57641754T>A	uc002qny.2	+	4	2067	c.1711T>A	c.(1711-1713)TCT>ACT	p.S571T		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	571					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGAGATGATTTCTGAGATCAA	0.468													A	57641754	A	A	57641754	3	1	132	1	0	0	0	0	1	0	0	0	17056	1783	62	5	1713	5	USP29	19	57641754	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08	2190111	57641754	1487229	107	9145											
SIRPB1	10326	broad.mit.edu	37	chr20	1600544	1600544	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccccagcagtagcgtcatcAgcaggaaaggactaggaagg	13	10	2	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr20:1600544A>G	uc010gai.2	-	1	146	c.47T>C	c.(46-48)CTG>CCG	p.L16P	SIRPB1_uc002wfk.3_Missense_Mutation_p.L16P|SIRPB1_uc002wfl.3_Missense_Mutation_p.L16P	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	16					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						TAGCGTCATCAGCAGGAAAGG	0.572													G	1600544	G	G	1600544	3	3	132	1	0	0	0	0	1	0	0	0	14333	188	7	4	2306	4	SIRPB1	20	1600544	Missense_Mutation	SNP	A	TCGA-14-0813-01A-01W-0424-08		1600544	61424976	108	9146											
NINL	22981	broad.mit.edu	37	chr20	25457045	25457045	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgaagcggccggcctcaggGgtggctcccacatccgtggc	15	15	1	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr20:25457045G>A	uc002wux.1	-	17	2956	c.2882C>T	c.(2881-2883)CCC>CTC	p.P961L	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	961					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CGGCCTCAGGGGTGGCTCCCA	0.692													A	25457045	A	A	25457045	3	1	132	1	0	0	0	0	1	0	0	0	10420	1232	43	3	1298	3	NINL	20	25457045	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	23856501	25457045	37568475	109	9147											
PPP1R16B	26051	broad.mit.edu	37	chr20	37547256	37547256	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccactcttaaagttcaagGcccccatagaggagatggag	10	12	2	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr20:37547256G>A	uc002xje.2	+	11	1840	c.1651G>A	c.(1651-1653)GCC>ACC	p.A551T	PPP1R16B_uc010ggc.2_Missense_Mutation_p.A509T	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	551	ANK 5.				regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				AAAGTTCAAGGCCCCCATAGA	0.577													A	37547256	A	A	37547256	3	1	132	1	0	0	0	0	1	0	0	0	12366	1203	42	3	1689	3	PPP1R16B	20	37547256	Missense_Mutation	SNP	G	TCGA-14-0813-01A-01W-0424-08	12090211	37547256	25478264	110	9148											
BMP7	655	broad.mit.edu	37	chr20	55777537	55777537	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgggggactcaccatccaGcgtctccaccgagagctgca	12	16	2	1			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr20:55777537G>A	uc010gip.1	-	3	1283	c.754C>T	c.(754-756)CTG>TTG	p.L252L	BMP7_uc010giq.1_Silent_p.L252L|BMP7_uc002xyc.2_Silent_p.L252L	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	252					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			TCACCATCCAGCGTCTCCACC	0.607													A	55777537	A	A	55777537	2	1	132	1	0	0	0	0	0	0	0	1	1465	962	34	3		3	BMP7	20	55777537	Silent	SNP	G	TCGA-14-0813-01A-01W-0424-08	18230281	55777537	7247983	111	9149											
CACNG2	10369	broad.mit.edu	37	chr22	36983511	36983511	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaacaatcgtgtgcactcaCggaggaaatattctgctgtg	10	8	2	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chr22:36983511C>T	uc003aps.1	-	2	577	c.295_splice	c.e2+1	p.R99_splice		NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2						membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						TGTGCACTCACGGAGGAAATA	0.507													T	36983511	T	T	36983511	5	4	132	1	0	0	0	0	0	0	1	0	2557	550	19	1	687	1	CACNG2	22	36983511	Splice_Site	SNP	C	TCGA-14-0813-01A-01W-0424-08		36983511	14321055	112	9150											
COL4A5	1287	broad.mit.edu	37	chrX	107827754	107827754	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cccacctggacctcctggacTtgtaagttttttttttttag	7	10	0	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chrX:107827754T>C	uc004enz.1	+	18	1233	c.1031T>C	c.(1030-1032)CTT>CCT	p.L344P	COL4A5_uc011mso.1_Missense_Mutation_p.L344P|COL4A5_uc004eob.1_5'UTR	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	344	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CCTCCTGGACTTGTAAGTTTT	0.343									Alport_syndrome_with_Diffuse_Leiomyomatosis				C	107827754	C	C	107827754	3	2	132	1	0	0	0	0	1	0	0	0	3694	1623	56	4	1101	4	COL4A5	23	107827754	Missense_Mutation	SNP	T	TCGA-14-0813-01A-01W-0424-08		107827754	47442806	113	9151											
AFF2	2334	broad.mit.edu	37	chrX	147743983	147743983	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggaagaatctgaattcgcCgtgcaagcgcctgggtctcc	12	13	2	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chrX:147743983C>T	uc004fcp.2	+	3	1214	c.735C>T	c.(733-735)GCC>GCT	p.A245A	AFF2_uc004fco.2_Silent_p.A241A|AFF2_uc004fcq.2_Silent_p.A241A|AFF2_uc004fcr.2_Silent_p.A241A|AFF2_uc011mxb.1_Silent_p.A245A|AFF2_uc004fcs.2_Silent_p.A241A	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	245					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CTGAATTCGCCGTGCAAGCGC	0.458													T	147743983	T	T	147743983	2	4	132	1	0	0	0	0	0	0	0	1	357	639	23	2		2	AFF2	23	147743983	Silent	SNP	C	TCGA-14-0813-01A-01W-0424-08	39916229	147743983	7526577	114	9152											
MAGEA12	4111	broad.mit.edu	37	chrX	151900520	151900520	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtcaggaaaggtgcttggcCcttcctgttcttcgttgctg	13	10	2	0			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chrX:151900520C>A	uc010ntp.2	-	3	635	c.281G>T	c.(280-282)GGG>GTG	p.G94V	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.G94V|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	94										skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGTGCTTGGCCCTTCCTGTTC	0.547													A	151900520	A	A	151900520	3	1	132	1	0	0	0	0	1	0	0	0	9166	623	22	5	667	5	MAGEA12	23	151900520	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	4156537	151900520	3370040	115	9153											
ARHGAP4	393	broad.mit.edu	37	chrX	153184317	153184317	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgggggtggtagtcaaagCgcagcgggggacagaagacg	19	7	1	2			TCGA-14-0813-01A-01W-0424-08	TCGA-14-0813-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	754cd19e-a319-4ddf-887b-ddca4914cdf9	ac74e345-6044-426b-9b56-eee2e8fc9f4b	g.chrX:153184317C>T	uc004fjk.1	-	7	1043	c.1001G>A	c.(1000-1002)CGC>CAC	p.R334H	ARHGAP4_uc011mzf.1_Missense_Mutation_p.R311H|ARHGAP4_uc004fjl.1_Missense_Mutation_p.R374H|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	334					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTAGTCAAAGCGCAGCGGGGG	0.617													T	153184317	T	T	153184317	3	4	132	1	0	0	0	0	1	0	0	0	885	768	27	1	1903	1	ARHGAP4	23	153184317	Missense_Mutation	SNP	C	TCGA-14-0813-01A-01W-0424-08	1283797	153184317	2086243	116	9154											
ARHGEF16	27237	broad.mit.edu	37	chr1	3395016	3395016	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctacatggtccaggactacGcccagatgaaccacatccag	9	14	0	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr1:3395016G>A	uc001akg.3	+	12	1902	c.1654G>A	c.(1654-1656)GCC>ACC	p.A552T	ARHGEF16_uc001aki.2_Missense_Mutation_p.A264T|ARHGEF16_uc001akj.2_Missense_Mutation_p.A264T|ARHGEF16_uc010nzh.1_Missense_Mutation_p.A256T	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	552	PH.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		CCAGGACTACGCCCAGATGAA	0.657													A	3395016	A	A	3395016	3	1	133	1	0	0	0	0	1	0	0	0	899	1087	38	1	1696	1	ARHGEF16	1	3395016	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08		3395016	245855605	1	9155											
HCRTR1	3061	broad.mit.edu	37	chr1	32084903	32084903	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttctccgctatctgtggcGcgattatctgtacccaaaac	8	12	3	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr1:32084903G>A	uc009vtx.2	+	3	495	c.110G>A	c.(109-111)CGC>CAC	p.R37H	HCRTR1_uc001btb.2_Intron|HCRTR1_uc001btc.3_Missense_Mutation_p.A11T|HCRTR1_uc001btd.2_Missense_Mutation_p.R37H|HCRTR1_uc010ogl.1_Missense_Mutation_p.R37H	NM_001525	NP_001516	O43613	OX1R_HUMAN	orexin receptor 1	37	Extracellular (Potential).				feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				ovary(1)	1		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		TATCTGTGGCGCGATTATCTG	0.607													A	32084903	A	A	32084903	3	1	133	1	0	0	0	0	1	0	0	0	7001	1087	38	1	112	1	HCRTR1	1	32084903	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	28689887	32084903	217165718	2	9156											
KANK4	163782	broad.mit.edu	37	chr1	62740564	62740564	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtcaggaaggctgaagtttCggggcagagtgctaaatttg	15	5	1	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr1:62740564C>T	uc001dah.3	-	3	589	c.212G>A	c.(211-213)CGA>CAA	p.R71Q	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	71										ovary(3)|skin(2)|lung(1)	6						GCTGAAGTTTCGGGGCAGAGT	0.557													T	62740564	T	T	62740564	3	4	133	1	0	0	0	0	1	0	0	0	7979	884	31	2	2807	2	KANK4	1	62740564	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	30655661	62740564	186510057	3	9157											
TGFBR3	7049	broad.mit.edu	37	chr1	92224221	92224221	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctctgtcttcagatgccaCaccagggggtgtggggagtt	14	10	3	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr1:92224221C>T	uc001doh.2	-	4	799	c.333G>A	c.(331-333)GTG>GTA	p.V111V	TGFBR3_uc009wde.2_Translation_Start_Site|TGFBR3_uc010osy.1_Silent_p.V69V|TGFBR3_uc001doi.2_Silent_p.V111V|TGFBR3_uc001doj.2_Silent_p.V111V	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	111	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TCAGATGCCACACCAGGGGGT	0.507													T	92224221	T	T	92224221	2	4	133	1	0	0	0	0	0	0	0	1	15820	465	17	3		3	TGFBR3	1	92224221	Silent	SNP	C	TCGA-14-0817-01A-01W-0424-08	29483657	92224221	157026400	4	9158											
PSRC1	84722	broad.mit.edu	37	chr1	109823399	109823399	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcctcctgacctcttacCcttgtgtccactttcccgca	4	18	2	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr1:109823399C>T	uc001dxg.2	-	5	1116	c.994G>A	c.(994-996)GTT>ATT	p.V332I	PSRC1_uc001dxb.2_Missense_Mutation_p.V132I|PSRC1_uc001dxc.2_Missense_Mutation_p.V302I|PSRC1_uc001dxd.2_Missense_Mutation_p.V302I|PSRC1_uc001dxe.2_Missense_Mutation_p.V302I|PSRC1_uc001dxf.2_Missense_Mutation_p.G268D|PSRC1_uc001dxh.2_Missense_Mutation_p.V302I|PSRC1_uc001dxi.2_Missense_Mutation_p.V302I|PSRC1_uc001dxj.2_Missense_Mutation_p.V332I	NM_001032290	NP_001027461	Q6PGN9	PSRC1_HUMAN	proline/serine-rich coiled-coil 1 isoform c	332	Pro/Ser-rich.				cell division|microtubule bundle formation|mitotic metaphase plate congression|negative regulation of cell growth|positive regulation of microtubule polymerization|positive regulation of transcription, DNA-dependent|regulation of mitotic spindle organization	cytosol|midbody|spindle pole	microtubule binding				0		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0286)|Lung(183;0.0658)|COAD - Colon adenocarcinoma(174;0.112)|Epithelial(280;0.188)|all cancers(265;0.213)		GACCTCTTACCCTTGTGTCCA	0.552													T	109823399	T	T	109823399	3	4	133	1	0	0	0	0	1	0	0	0	12719	637	22	3	141	3	PSRC1	1	109823399	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	17599178	109823399	139427222	5	9159											
SYT6	148281	broad.mit.edu	37	chr1	114682285	114682285	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgctgcagccgggtgtgaCgcatgatgtgctccttgacc	14	13	0	3	rs138691067		TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr1:114682285C>T	uc001eev.2	-	2	459	c.209G>A	c.(208-210)CGT>CAT	p.R70H		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	155	Cytoplasmic (Potential).				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCGGGTGTGACGCATGATGTG	0.622													T	114682285	T	T	114682285	3	4	133	1	0	0	0	0	1	0	0	0	15475	536	19	1	1092	1	SYT6	1	114682285	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	4858886	114682285	134568336	6	9160											
FLG	2312	broad.mit.edu	37	chr1	152282266	152282266	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacagatgaatcttgtctgCgcccagtgcctgagtctgtg	11	11	3	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr1:152282266C>T	uc001ezu.1	-	3	5132	c.5096G>A	c.(5095-5097)CGC>CAC	p.R1699H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1699	Ser-rich.|Filaggrin 10.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCTTGTCTGCGCCCAGTGCC	0.572									Ichthyosis				T	152282266	T	T	152282266	3	4	133	1	0	0	0	0	1	0	0	0	5922	768	27	1	7093	1	FLG	1	152282266	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	37599981	152282266	96968355	7	9161											
PKLR	5313	broad.mit.edu	37	chr1	155264433	155264433	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgaagcgcaggtctcggaCgtcctgctcggacagcccgg	14	16	1	0	rs142395015	by1000genomes	TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr1:155264433C>T	uc001fkb.3	-	6	844	c.805G>A	c.(805-807)GTC>ATC	p.V269I	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Missense_Mutation_p.V238I	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	269					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	AGGTCTCGGACGTCCTGCTCG	0.672													T	155264433	T	T	155264433	3	4	133	1	0	0	0	0	1	0	0	0	11976	536	19	1	943	1	PKLR	1	155264433	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	2982167	155264433	93986188	8	9162											
KCNH1	3756	broad.mit.edu	37	chr1	210977475	210977475	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatctgttggaaaatagtcGtcacattcccgaagatggtg	10	8	2	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr1:210977475G>A	uc001hib.2	-	8	1666	c.1496C>T	c.(1495-1497)ACG>ATG	p.T499M	KCNH1_uc001hic.2_Missense_Mutation_p.T472M	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	499	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GAAAATAGTCGTCACATTCCC	0.478													A	210977475	A	A	210977475	3	1	133	1	0	0	0	0	1	0	0	0	8031	1145	40	1	1489	1	KCNH1	1	210977475	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	55713042	210977475	38273146	9	9163											
AUP1	550	broad.mit.edu	37	chr2	74756731	74756731	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgagtcaaagagccgctccGgccccggccctgagggaagc	15	15	1	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr2:74756731G>A	uc010yry.1	-	1	244	c.26C>T	c.(25-27)CCG>CTG	p.P9L	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_Missense_Mutation_p.P9L|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_5'UTR|AUP1_uc010yrx.1_Missense_Mutation_p.R40W|HTRA2_uc002smi.1_5'UTR|HTRA2_uc002smj.1_5'UTR|HTRA2_uc002smk.1_5'UTR|HTRA2_uc002sml.1_5'UTR|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ58836, highly similar to Ancient ubiquitous protein 1;	9	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						GAGCCGCTCCGGCCCCGGCCC	0.711													A	74756731	A	A	74756731	3	1	133	1	0	0	0	0	1	0	0	0	1220	1116	39	2	1254	2	AUP1	2	74756731	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08		74756731	168442642	10	9164											
ASTL	431705	broad.mit.edu	37	chr2	96795617	96795617	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgtagagtttgaggacccGggtgatgtccgaggcactca	15	10	1	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr2:96795617G>A	uc010yui.1	-	8	820	c.820C>T	c.(820-822)CGG>TGG	p.R274W		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	274					proteolysis		metalloendopeptidase activity|zinc ion binding				0						TTGAGGACCCGGGTGATGTCC	0.652													A	96795617	A	A	96795617	3	1	133	1	0	0	0	0	1	0	0	0	1063	1115	39	2	482	2	ASTL	2	96795617	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	22038886	96795617	146403756	11	9165											
ACMSD	130013	broad.mit.edu	37	chr2	135621053	135621053	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctaccccaggaggttcgtggGtctggggacgttgcccatgc	15	12	1	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr2:135621053G>T	uc002ttz.2	+	5	405	c.338G>T	c.(337-339)GGT>GTT	p.G113V	ACMSD_uc002tua.2_Missense_Mutation_p.G55V	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	113					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		AGGTTCGTGGGTCTGGGGACG	0.587													T	135621053	T	T	135621053	3	4	133	1	0	0	0	0	1	0	0	0	144	1261	44	5	356	5	ACMSD	2	135621053	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	38825436	135621053	107578320	12	9166											
SCN7A	6332	broad.mit.edu	37	chr2	167263066	167263066	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctttggtccttttccaagaCgcagcatgtgaatgatccgt	9	11	0	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr2:167263066C>T	uc002udu.1	-	25	4200	c.4073G>A	c.(4072-4074)CGT>CAT	p.R1358H		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1358	Helical; Voltage-sensor; Name=S4 of repeat IV; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TTTTCCAAGACGCAGCATGTG	0.468													T	167263066	T	T	167263066	3	4	133	1	0	0	0	0	1	0	0	0	13923	536	19	1	979	1	SCN7A	2	167263066	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	31642013	167263066	75936307	13	9167											
TTN	7273	broad.mit.edu	37	chr2	179575562	179575562	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctttatcggttgtgtgcccGtgacgtggcactcaaagtca	11	11	2	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr2:179575562G>A	uc010zfg.1	-	95	24754	c.24530C>T	c.(24529-24531)ACG>ATG	p.T8177M	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T4838M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9104							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTGTGCCCGTGACGTGGCA	0.522													A	179575562	A	A	179575562	3	1	133	1	0	0	0	0	1	0	0	0	16732	1145	40	1	76327	1	TTN	2	179575562	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	12312496	179575562	63623811	14	9168											
PLCL1	5334	broad.mit.edu	37	chr2	198968641	198968641	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaactgagagctttgcttGgaacattacagtattgaagg	11	6	0	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr2:198968641G>A	uc010fsp.2	+	5	3377	c.3086G>A	c.(3085-3087)TGG>TAG	p.W1029*	PLCL1_uc002uuv.3_Nonsense_Mutation_p.W950*	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	1029					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AGCTTTGCTTGGAACATTACA	0.403													A	198968641	A	A	198968641	4	1	133	1	0	0	0	0	0	1	0	0	12039	1357	47	3	3104	3	PLCL1	2	198968641	Nonsense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	19393079	198968641	44230732	15	9169											
ESPNL	339768	broad.mit.edu	37	chr2	239039147	239039147	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggtgcagccacatctccCgcctggtacgcagcctgtcc	10	17	2	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr2:239039147C>T	uc002vxq.3	+	9	1902	c.1792C>T	c.(1792-1794)CGC>TGC	p.R598C	ESPNL_uc010fyw.2_Missense_Mutation_p.R294C	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	598										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CCACATCTCCCGCCTGGTACG	0.692													T	239039147	T	T	239039147	3	4	133	1	0	0	0	0	1	0	0	0	5255	652	23	2	1826	2	ESPNL	2	239039147	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	40070506	239039147	4160226	16	9170											
CSPG5	10675	broad.mit.edu	37	chr3	47619104	47619104	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggaatggcagggggcatgaTtgactgcccgaggacctcgt	16	9	0	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr3:47619104T>C	uc003crp.3	-	2	588	c.412A>G	c.(412-414)ATC>GTC	p.I138V	CSPG5_uc003crn.2_5'UTR|CSPG5_uc003cro.3_Missense_Mutation_p.I138V|CSPG5_uc011bbb.1_5'UTR	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	138	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GGGGGCATGATTGACTGCCCG	0.692													C	47619104	C	C	47619104	3	2	133	1	0	0	0	0	1	0	0	0	3961	1493	52	4	1223	4	CSPG5	3	47619104	Missense_Mutation	SNP	T	TCGA-14-0817-01A-01W-0424-08		47619104	150403326	17	9171											
KBTBD12	166348	broad.mit.edu	37	chr3	127682174	127682174	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcactccgcaccaattccacCaatgcaggggcagtggatgg	11	13	1	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr3:127682174C>T	uc010hsr.2	+	4	1638	c.1635C>T	c.(1633-1635)ACC>ACT	p.T545T	KBTBD12_uc003ejy.3_Silent_p.T152T|KBTBD12_uc010hsq.2_RNA|KBTBD12_uc003eka.3_Silent_p.T120T	NM_207335	NP_997218	Q3ZCT8	KBTBC_HUMAN	kelch domain containing 6	545	Kelch 3.									ovary(1)	1						CCAATTCCACCAATGCAGGGG	0.532													T	127682174	T	T	127682174	2	4	133	1	0	0	0	0	0	0	0	1	7991	581	21	3		3	KBTBD12	3	127682174	Silent	SNP	C	TCGA-14-0817-01A-01W-0424-08	80063070	127682174	70340256	18	9172											
CNGA1	1259	broad.mit.edu	37	chr4	47938532	47938532	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcagaaatttctcaaccttgGttaatctttgtttcagtttc	5	8	4	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr4:47938532G>T	uc003gxt.3	-	11	2245	c.1979C>A	c.(1978-1980)ACC>AAC	p.T660N	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.T729N	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	660	Cytoplasmic (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						CTCAACCTTGGTTAATCTTTG	0.463													T	47938532	T	T	47938532	3	4	133	1	0	0	0	0	1	0	0	0	3596	1261	44	5	97	5	CNGA1	4	47938532	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08		47938532	143215744	19	9173											
CENPE	1062	broad.mit.edu	37	chr4	104068560	104068560	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tttcagctggtcatgtttaaCttcaagggcttcttttatcg	8	8	4	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr4:104068560C>A	uc003hxb.1	-	29	4177	c.4087G>T	c.(4087-4089)GTT>TTT	p.V1363F	CENPE_uc003hxc.1_Missense_Mutation_p.V1338F	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1363	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TCATGTTTAACTTCAAGGGCT	0.343													A	104068560	A	A	104068560	3	1	133	1	0	0	0	0	1	0	0	0	3230	565	20	5	4102	5	CENPE	4	104068560	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	56130028	104068560	87085716	20	9174											
FBXW7	55294	broad.mit.edu	37	chr4	153244185	153244185	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctccaatgtgactaggtttcGaataaattcacccgttttca	6	10	2	1	rs144247898		TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr4:153244185G>A	uc003ims.2	-	12	2121	c.1972C>T	c.(1972-1974)CGA>TGA	p.R658*	FBXW7_uc011cii.1_Nonsense_Mutation_p.R658*|FBXW7_uc003imt.2_Nonsense_Mutation_p.R658*|FBXW7_uc011cih.1_Nonsense_Mutation_p.R482*|FBXW7_uc003imq.2_Nonsense_Mutation_p.R578*|FBXW7_uc003imr.2_Nonsense_Mutation_p.R540*	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	658	WD 7.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R658*(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACTAGGTTTCGAATAAATTCA	0.473			Mis|N|D|F		colorectal|endometrial|T-ALL								A	153244185	A	A	153244185	4	1	133	1	0	0	0	0	0	1	0	0	5769	1066	37	2	155	2	FBXW7	4	153244185	Nonsense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	49175625	153244185	37910091	21	9175											
NPY5R	4889	broad.mit.edu	37	chr4	164271738	164271738	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cactgacgtctgtcttgctgGatcagtggatgtttggcaaa	12	8	3	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr4:164271738G>C	uc003iqn.2	+	4	495	c.313G>C	c.(313-315)GAT>CAT	p.D105H		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	105	Extracellular (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				TGTCTTGCTGGATCAGTGGAT	0.393													C	164271738	C	C	164271738	3	2	133	1	0	0	0	0	1	0	0	0	10610	1174	41	5	315	5	NPY5R	4	164271738	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	11027553	164271738	26882538	22	9176											
SLC9A3	6550	broad.mit.edu	37	chr5	482707	482707	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacgatgatggtggtgctgaCgaacaggttcttctccttga	12	8	2	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr5:482707C>T	uc003jbe.2	-	7	1424	c.1312G>A	c.(1312-1314)GTC>ATC	p.V438I	SLC9A3_uc011clx.1_Missense_Mutation_p.V438I	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	438	Helical; Name=M/M10; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GTGGTGCTGACGAACAGGTTC	0.652													T	482707	T	T	482707	3	4	133	1	0	0	0	0	1	0	0	0	14713	536	19	1	1236	1	SLC9A3	5	482707	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08		482707	180432553	23	9177											
GPR98	84059	broad.mit.edu	37	chr5	89954051	89954051	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taacaatacaaaaaagtgacAatgcaaatggcttgtttggt	8	5	0	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr5:89954051A>G	uc003kju.2	+	21	4804	c.4708A>G	c.(4708-4710)AAT>GAT	p.N1570D	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1570	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAAAAGTGACAATGCAAATGG	0.343													G	89954051	G	G	89954051	3	3	133	1	0	0	0	0	1	0	0	0	6721	130	5	4	4790	4	GPR98	5	89954051	Missense_Mutation	SNP	A	TCGA-14-0817-01A-01W-0424-08	89471344	89954051	90961209	24	9178											
NUP153	9972	broad.mit.edu	37	chr6	17616339	17616339	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtgacctttatttcctgcGtctaacagcagtctttatct	6	10	3	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr6:17616339G>A	uc003ncd.1	-	22	4617	c.4417C>T	c.(4417-4419)CGC>TGC	p.R1473C	NUP153_uc011dje.1_Missense_Mutation_p.R1504C|NUP153_uc010jpl.1_Missense_Mutation_p.R1431C	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	1473					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TATTTCCTGCGTCTAACAGCA	0.388													A	17616339	A	A	17616339	3	1	133	1	0	0	0	0	1	0	0	0	10755	1145	40	1	14	1	NUP153	6	17616339	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08		17616339	153498728	25	9179											
SUPT3H	8464	broad.mit.edu	37	chr6	44922308	44922308	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttttatctccatactgctgCagtccaaccagtctcgaaat	6	12	2	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr6:44922308C>T	uc003oxo.2	-	10	968	c.650G>A	c.(649-651)TGC>TAC	p.C217Y	SUPT3H_uc003oxn.1_Missense_Mutation_p.C206Y|SUPT3H_uc011dvv.1_Missense_Mutation_p.C54Y|SUPT3H_uc003oxp.2_Missense_Mutation_p.C206Y|SUPT3H_uc011dvw.1_Missense_Mutation_p.C120Y	NM_181356	NP_852001	O75486	SUPT3_HUMAN	suppressor of Ty 3 homolog isoform 2	288					histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			ovary(2)|breast(1)	3						CATACTGCTGCAGTCCAACCA	0.348													T	44922308	T	T	44922308	3	4	133	1	0	0	0	0	1	0	0	0	15394	710	25	3	352	3	SUPT3H	6	44922308	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	27305969	44922308	126192759	26	9180											
MEP1A	4224	broad.mit.edu	37	chr6	46761453	46761453	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atatttcagaaatcaatttaGgtgagttcaatttttgtgtt	7	3	3	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr6:46761453G>A	uc010jzh.1	+	3	187	c.145G>A	c.(145-147)GCT>ACT	p.A49T	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Missense_Mutation_p.A77T|MEP1A_uc011dwi.1_5'UTR	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	49					digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			AATCAATTTAGGTGAGTTCAA	0.313													A	46761453	A	A	46761453	3	1	133	1	0	0	0	0	1	0	0	0	9475	1014	35	3	155	3	MEP1A	6	46761453	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	1839145	46761453	124353614	27	9181											
HTR1E	3354	broad.mit.edu	37	chr6	87725079	87725079	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcacaaactgtaccacagaGgccagcatggctataagacc	8	12	1	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr6:87725079G>A	uc003pli.2	+	2	730	c.27G>A	c.(25-27)GAG>GAA	p.E9E		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	9	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	GTACCACAGAGGCCAGCATGG	0.473													A	87725079	A	A	87725079	2	1	133	1	0	0	0	0	0	0	0	1	7439	991	35	3		3	HTR1E	6	87725079	Silent	SNP	G	TCGA-14-0817-01A-01W-0424-08	40963626	87725079	83389988	28	9182											
GRM1	2911	broad.mit.edu	37	chr6	146720758	146720758	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgtccgcatgcatgttggCgatggcaagctgccctgccg	14	12	0	0	rs148042148		TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr6:146720758C>T	uc010khw.1	+	8	3053	c.2583C>T	c.(2581-2583)GGC>GGT	p.G861G	GRM1_uc010khv.1_Silent_p.G861G|GRM1_uc003qll.2_Silent_p.G861G|GRM1_uc011edz.1_Silent_p.G861G|GRM1_uc011eea.1_Silent_p.G861G	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	861	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TGCATGTTGGCGATGGCAAGC	0.517													T	146720758	T	T	146720758	2	4	133	1	0	0	0	0	0	0	0	1	6796	755	27	1		1	GRM1	6	146720758	Silent	SNP	C	TCGA-14-0817-01A-01W-0424-08	58995679	146720758	24394309	29	9183											
SYNE1	23345	broad.mit.edu	37	chr6	152763368	152763368	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcttctttgctgagatccGctttgtcttttgctagaagc	8	10	3	2	rs140780725		TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr6:152763368G>A	uc010kiw.2	-	31	4452	c.3850C>T	c.(3850-3852)CGG>TGG	p.R1284W	SYNE1_uc003qot.3_Missense_Mutation_p.R1291W|SYNE1_uc003qou.3_Missense_Mutation_p.R1284W|SYNE1_uc010kjb.1_Missense_Mutation_p.R1267W|SYNE1_uc003qow.2_Missense_Mutation_p.R579W|SYNE1_uc003qox.1_Missense_Mutation_p.R800W	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1284	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCTGAGATCCGCTTTGTCTTT	0.512										HNSCC(10;0.0054)			A	152763368	A	A	152763368	3	1	133	1	0	0	0	0	1	0	0	0	15442	1086	38	1	23080	1	SYNE1	6	152763368	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	6042610	152763368	18351699	30	9184											
SLC22A2	6582	broad.mit.edu	37	chr6	160662608	160662608	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattgaggaacagatgtggaCgccaagattcctagaatgca	11	8	0	4			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr6:160662608C>T	uc003qtf.2	-	9	1569	c.1399G>A	c.(1399-1401)GTC>ATC	p.V467I	SLC22A2_uc003qte.1_Missense_Mutation_p.V467I	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	467	Helical; (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CAGATGTGGACGCCAAGATTC	0.453													T	160662608	T	T	160662608	3	4	133	1	0	0	0	0	1	0	0	0	14450	536	19	1	280	1	SLC22A2	6	160662608	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	7899240	160662608	10452459	31	9185											
UNC93A	54346	broad.mit.edu	37	chr6	167728686	167728686	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctctgcagctctctacggcGttctgtttgagaagagcaag	11	11	3	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr6:167728686G>A	uc003qvq.2	+	8	1295	c.1120G>A	c.(1120-1122)GTT>ATT	p.V374I	UNC93A_uc003qvr.2_Missense_Mutation_p.V332I	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	374						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TCTCTACGGCGTTCTGTTTGA	0.567													A	167728686	A	A	167728686	3	1	133	1	0	0	0	0	1	0	0	0	16993	1145	40	1	1150	1	UNC93A	6	167728686	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	7066078	167728686	3386381	32	9186											
CALN1	83698	broad.mit.edu	37	chr7	71488740	71488740	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ggtcatgaattcatcaaaatCcacctggccatcccctgcaa	6	14	3	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr7:71488740C>A	uc003twa.3	-	4	804	c.277G>T	c.(277-279)GAT>TAT	p.D93Y	CALN1_uc003twb.3_Missense_Mutation_p.D135Y|CALN1_uc003twc.3_Missense_Mutation_p.D93Y	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	93	2 (Potential).|EF-hand 2.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TCATCAAAATCCACCTGGCCA	0.458													A	71488740	A	A	71488740	3	1	133	1	0	0	0	0	1	0	0	0	2591	855	30	5	394	5	CALN1	7	71488740	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08		71488740	87649923	33	9187											
ABCB1	5243	broad.mit.edu	37	chr7	87148697	87148697	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccaagtaggctccaaaccGgaaacatccagcataggaaa	8	12	0	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr7:87148697G>A	uc003uiz.1	-	24	3290	c.2872C>T	c.(2872-2874)CGG>TGG	p.R958W	ABCB1_uc011khc.1_Missense_Mutation_p.R894W	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	958	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GCTCCAAACCGGAAACATCCA	0.323													A	87148697	A	A	87148697	3	1	133	1	0	0	0	0	1	0	0	0	40	1115	39	2	994	2	ABCB1	7	87148697	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	15659957	87148697	71989966	34	9188											
PEX1	5189	broad.mit.edu	37	chr7	92120719	92120719	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caagggactgatctaagccaCattctccatctccagctgaa	7	13	3	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr7:92120719C>A	uc003uly.2	-	21	3401	c.3305G>T	c.(3304-3306)TGT>TTT	p.C1102F	PEX1_uc011khr.1_Missense_Mutation_p.C894F|PEX1_uc010ley.2_Missense_Mutation_p.C1045F|PEX1_uc011khs.1_Missense_Mutation_p.C780F	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	1102					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			ATCTAAGCCACATTCTCCATC	0.428													A	92120719	A	A	92120719	3	1	133	1	0	0	0	0	1	0	0	0	11735	478	17	5	562	5	PEX1	7	92120719	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	4972022	92120719	67017944	35	9189											
NPTX2	4885	broad.mit.edu	37	chr7	98254301	98254301	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccgcacaaactacctataCggcaagatcaagaagacgct	7	13	1	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr7:98254301C>T	uc003upl.2	+	3	888	c.711C>T	c.(709-711)TAC>TAT	p.Y237Y		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	237	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			ACTACCTATACGGCAAGATCA	0.587													T	98254301	T	T	98254301	2	4	133	1	0	0	0	0	0	0	0	1	10603	547	19	1		1	NPTX2	7	98254301	Silent	SNP	C	TCGA-14-0817-01A-01W-0424-08	6133582	98254301	60884362	36	9190											
LMOD2	442721	broad.mit.edu	37	chr7	123302696	123302696	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcattttgacaagaaatatGgataaacagaggcaaaaacg	9	5	0	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr7:123302696G>A	uc003vky.2	+	2	1213	c.1056G>A	c.(1054-1056)ATG>ATA	p.M352I		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	352						cytoskeleton	actin binding|tropomyosin binding				0						CAAGAAATATGGATAAACAGA	0.473													A	123302696	A	A	123302696	3	1	133	1	0	0	0	0	1	0	0	0	8857	1348	47	3	1062	3	LMOD2	7	123302696	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	25048395	123302696	35835967	37	9191											
TRPV5	56302	broad.mit.edu	37	chr7	142622682	142622682	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgagtgcggttgccaccaCgaaacttaagggggcggtag	15	8	0	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr7:142622682C>T	uc003wby.1	-	8	1328	c.1064G>A	c.(1063-1065)CGT>CAT	p.R355H	TRPV5_uc003wbz.2_Missense_Mutation_p.R355H	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	355	Extracellular (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity	p.R355L(1)|p.R355H(1)		ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GTTGCCACCACGAAACTTAAG	0.517													T	142622682	T	T	142622682	3	4	133	1	0	0	0	0	1	0	0	0	16596	536	19	1	1157	1	TRPV5	7	142622682	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	19319986	142622682	16515981	38	9192											
OR2A12	346525	broad.mit.edu	37	chr7	143792808	143792808	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcctatttgcgggttctgCgttcatcttagtggggccgc	14	10	3	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr7:143792808C>T	uc011kty.1	+	1	608	c.608C>T	c.(607-609)GCG>GTG	p.A203V		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					GCGGGTTCTGCGTTCATCTTA	0.537													T	143792808	T	T	143792808	3	4	133	1	0	0	0	0	1	0	0	0	10975	768	27	1	610	1	OR2A12	7	143792808	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	1170126	143792808	15345855	39	9193											
SSPO	23145	broad.mit.edu	37	chr7	149502623	149502623	+	Frame_Shift_Del	DEL	C	-	-													agccctggggattcatcctgCccaggagatgccacccagga							TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr7:149502623delC	uc010lpk.2	+	58	8436	c.8436delC	c.(8434-8436)TGCfs	p.C2812fs		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2812	TSP type-1 7.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATTCATCCTGCCCAGGAGATG	0.682													-	149502623	-	-	149502623	7	5	133	1	0	1	0	1	0	0	0	0	15188	747	26	0	8658	0	SSPO	7	149502623	Frame_Shift_Del	DEL	C	TCGA-14-0817-01A-01W-0424-08	5709815	149502623	9636040	40	9194											
NOS3	4846	broad.mit.edu	37	chr7	150703567	150703567	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccctacaacagctcccctcGgccggaacagcacaagtgag	9	17	0	1	rs145168353	byFrequency	TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr7:150703567G>A	uc003wif.2	+	15	2101	c.1805G>A	c.(1804-1806)CGG>CAG	p.R602Q	NOS3_uc011kuy.1_Missense_Mutation_p.R396Q	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	602	Flavodoxin-like.		R -> Q (in a colorectal cancer sample; somatic mutation).		anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding	p.R602Q(1)		central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	AGCTCCCCTCGGCCGGAACAG	0.542													A	150703567	A	A	150703567	3	1	133	1	0	0	0	0	1	0	0	0	10544	1116	39	2	2141	2	NOS3	7	150703567	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	1200944	150703567	8435096	41	9195											
PRSS55	203074	broad.mit.edu	37	chr8	10390524	10390524	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taccaaaaatatgctgtgtgCcggatacaagaatgagagct	10	7	0	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr8:10390524C>T	uc003wta.2	+	4	722	c.707C>T	c.(706-708)GCC>GTC	p.A236V	uc010lru.2_Intron|PRSS55_uc003wtb.2_RNA	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	236	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						ATGCTGTGTGCCGGATACAAG	0.483													T	10390524	T	T	10390524	3	4	133	1	0	0	0	0	1	0	0	0	12634	739	26	3	721	3	PRSS55	8	10390524	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08		10390524	135973498	42	9196											
PHYHIP	9796	broad.mit.edu	37	chr8	22079191	22079191	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtacatgcagtagaagtccGcaaagtagaggttggtgctg	14	6	0	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr8:22079191G>A	uc003xbk.3	-	6	1362	c.668C>T	c.(667-669)GCG>GTG	p.A223V	PHYHIP_uc003xbj.3_Missense_Mutation_p.A223V	NM_001099335	NP_001092805	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	223											0				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		GTAGAAGTCCGCAAAGTAGAG	0.657													A	22079191	A	A	22079191	3	1	133	1	0	0	0	0	1	0	0	0	11866	1087	38	1	328	1	PHYHIP	8	22079191	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	11688667	22079191	124284831	43	9197											
SULF1	23213	broad.mit.edu	37	chr8	70536309	70536309	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accaagaaacattgctaagcGtcatgatgaaggccacaagg	10	9	1	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr8:70536309G>A	uc010lza.1	+	15	2444	c.1727G>A	c.(1726-1728)CGT>CAT	p.R576H	SULF1_uc003xyd.2_Missense_Mutation_p.R576H|SULF1_uc003xye.2_Missense_Mutation_p.R576H|SULF1_uc003xyf.2_Missense_Mutation_p.R576H|SULF1_uc003xyg.2_Missense_Mutation_p.R576H|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	576					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ATTGCTAAGCGTCATGATGAA	0.498													A	70536309	A	A	70536309	3	1	133	1	0	0	0	0	1	0	0	0	15369	1145	40	1	1769	1	SULF1	8	70536309	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	48457118	70536309	75827713	44	9198											
SLCO5A1	81796	broad.mit.edu	37	chr8	70744225	70744225	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtcgttgggggccgaggcGttcaactcttggatctggta	15	10	3	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr8:70744225G>A	uc003xyl.2	-	2	1391	c.684C>T	c.(682-684)AAC>AAT	p.N228N	SLCO5A1_uc010lzb.2_Silent_p.N228N|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Silent_p.N228N|SLCO5A1_uc010lzc.2_Silent_p.N228N	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	228	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GGGCCGAGGCGTTCAACTCTT	0.637													A	70744225	A	A	70744225	2	1	133	1	0	0	0	0	0	0	0	1	14731	1136	40	1		1	SLCO5A1	8	70744225	Silent	SNP	G	TCGA-14-0817-01A-01W-0424-08	207916	70744225	75619797	45	9199											
KIAA1161	57462	broad.mit.edu	37	chr9	34372688	34372688	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccgcgcgaagtcgctccGccttgcgtagggagacgctg	15	14	0	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr9:34372688G>A	uc003zue.3	-	3	421	c.254C>T	c.(253-255)GCG>GTG	p.A85V		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	85	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		AAGTCGCTCCGCCTTGCGTAG	0.662													A	34372688	A	A	34372688	3	1	133	1	0	0	0	0	1	0	0	0	8211	1087	38	1	1894	1	KIAA1161	9	34372688	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08		34372688	106840743	46	9200											
KIAA1539	80256	broad.mit.edu	37	chr9	35108015	35108015	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggtagtccctctctggccCccagcccagggcctctcttc	11	18	2	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr9:35108015C>T	uc003zwl.2	-	3	582	c.257G>A	c.(256-258)GGG>GAG	p.G86E	KIAA1539_uc003zwm.2_Missense_Mutation_p.G86E|KIAA1539_uc003zwn.2_Intron|KIAA1539_uc003zwo.2_Missense_Mutation_p.G86E|KIAA1539_uc003zwp.1_Missense_Mutation_p.G86E|KIAA1539_uc010mkk.1_Intron	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	86						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CTCTCTGGCCCCCAGCCCAGG	0.637													T	35108015	T	T	35108015	3	4	133	1	0	0	0	0	1	0	0	0	8242	623	22	3	1387	3	KIAA1539	9	35108015	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	735327	35108015	106105416	47	9201											
USP20	10868	broad.mit.edu	37	chr9	132625554	132625555	+	Frame_Shift_Del	DEL	TC	-	-													caagagctaccagaagctggTctctgaggtctggcataaga							TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr9:132625554_132625555delTC	uc004bys.2	+	9	798_799	c.587_588delTC	c.(586-588)GTCfs	p.V196fs	USP20_uc004byr.2_Frame_Shift_Del_p.V196fs|USP20_uc004byt.1_Frame_Shift_Del_p.V196fs	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	196					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				CAGAAGCTGGTCTCTGAGGTCT	0.569													-	132625555	-	-	132625554	7	5	133	1	0	1	0	1	0	0	0	0	17049	1667	58	0	613	0	USP20	9	132625554	Frame_Shift_Del	DEL	TC	TCGA-14-0817-01A-01W-0424-08	97517539	132625554	8587877	48	9202											
FAM107B	83641	broad.mit.edu	37	chr10	14816316	14816316	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaccactgcttcacagtccGccccatcatccagggacccg	7	19	2	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr10:14816316G>A	uc001ina.1	-	1	581	c.347C>T	c.(346-348)GCG>GTG	p.A116V	FAM107B_uc010qbu.1_RNA	NM_031453	NP_113641	Q9H098	F107B_HUMAN	hypothetical protein LOC83641	Error:Variant_position_missing_in_Q9H098_after_alignment										breast(4)	4						TTCACAGTCCGCCCCATCATC	0.572													A	14816316	A	A	14816316	3	1	133	1	0	0	0	0	1	0	0	0	5390	1087	38	1	593	1	FAM107B	10	14816316	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08		14816316	120718431	49	9203											
AGAP5	729092	broad.mit.edu	37	chr10	75434500	75434500	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaccagatcaggagctgtgCcaggaccacattccccttgc	10	14	1	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr10:75434500C>T	uc009xri.2	-	8	1959	c.1918G>A	c.(1918-1920)GCA>ACA	p.A640T	AGAP5_uc001juu.3_Missense_Mutation_p.A601T	NM_001144000	NP_001137472	A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	640	ANK 1.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						AGGAGCTGTGCCAGGACCACA	0.667													T	75434500	T	T	75434500	3	4	133	1	0	0	0	0	1	0	0	0	371	739	26	3	146	3	AGAP5	10	75434500	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	60618184	75434500	60100247	50	9204											
C10orf12	26148	broad.mit.edu	37	chr10	98741767	98741767	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtgagctgccaactgttcGtacactggccagaaatttac	9	10	0	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr10:98741767G>A	uc001kmv.2	+	1	727	c.620G>A	c.(619-621)CGT>CAT	p.R207H	C10orf12_uc009xvg.1_Missense_Mutation_p.R517H	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	207										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CCAACTGTTCGTACACTGGCC	0.433													A	98741767	A	A	98741767	3	1	133	1	0	0	0	0	1	0	0	0	1589	1145	40	1	622	1	C10orf12	10	98741767	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	23307267	98741767	36792980	51	9205											
FANK1	92565	broad.mit.edu	37	chr10	127677132	127677132	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgtctaggggatatgcaacGaagcatgttgttgaaggtct	13	6	2	1	rs146192515		TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr10:127677132G>A	uc001ljh.3	+	3	308	c.204G>A	c.(202-204)ACG>ACA	p.T68T	FANK1_uc010quk.1_Silent_p.T62T|FANK1_uc009yan.2_Silent_p.T68T|FANK1_uc001lji.2_Silent_p.T62T	NM_145235	NP_660278	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains	68	Fibronectin type-III.					cytoplasm|nucleus				ovary(1)	1		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				GATATGCAACGAAGCATGTTG	0.512													A	127677132	A	A	127677132	2	1	133	1	0	0	0	0	0	0	0	1	5672	1045	37	2		2	FANK1	10	127677132	Silent	SNP	G	TCGA-14-0817-01A-01W-0424-08	28935365	127677132	7857615	52	9206											
INS	3630	broad.mit.edu	37	chr11	2181082	2181082	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gggctgcctgcgggctgcgtCtagttgcagtagttctccag	15	11	2	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr11:2181082C>T	uc001lvn.1	-	3	388	c.333G>A	c.(331-333)TAG>TAA	p.*111*	INS-IGF2_uc001lvi.2_Intron|INS-IGF2_uc001lvm.2_Intron|INS_uc001lvo.1_Silent_p.*111*|INS_uc009ydg.1_Silent_p.*99*	NM_000207	NP_000198	P01308	INS_HUMAN	proinsulin precursor	111					activation of protein kinase B activity|acute-phase response|alpha-beta T cell activation|endocrine pancreas development|energy reserve metabolic process|fatty acid homeostasis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|glucose metabolic process|glucose transport|insulin receptor signaling pathway|MAPKKK cascade|negative regulation of acute inflammatory response|negative regulation of apoptosis|negative regulation of fatty acid metabolic process|negative regulation of feeding behavior|negative regulation of gluconeogenesis|negative regulation of glycogen catabolic process|negative regulation of lipid catabolic process|negative regulation of NAD(P)H oxidase activity|negative regulation of protein catabolic process|negative regulation of protein secretion|negative regulation of proteolysis|negative regulation of respiratory burst involved in inflammatory response|negative regulation of vasodilation|positive regulation of cell differentiation|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine secretion|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin receptor signaling pathway|positive regulation of lipid biosynthetic process|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of respiratory burst|positive regulation of vasodilation|regulation of cellular amino acid metabolic process|regulation of insulin secretion|regulation of transmembrane transporter activity|wound healing	endoplasmic reticulum lumen|endosome lumen|extracellular space	hormone activity|insulin receptor binding|insulin-like growth factor receptor binding				0		Lung NSC(207;8.94e-06)|all_epithelial(84;3.17e-05)|all_lung(207;3.67e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.14)		CGGGCTGCGTCTAGTTGCAGT	0.612													T	2181082	T	T	2181082	2	4	133	1	0	0	0	0	0	0	0	1	7762	924	32	3		3	INS	11	2181082	Silent	SNP	C	TCGA-14-0817-01A-01W-0424-08		2181082	132825434	53	9207											
SLC5A12	159963	broad.mit.edu	37	chr11	26734241	26734241	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgaactggtttgttgaatcGtagttgtaagtactaaagga	12	4	0	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr11:26734241G>A	uc001mra.2	-	2	665	c.352C>T	c.(352-354)CGA>TGA	p.R118*	SLC5A12_uc001mrb.2_RNA|SLC5A12_uc001mrc.3_Nonsense_Mutation_p.R118*	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	118	Cytoplasmic (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						TTGTTGAATCGTAGTTGTAAG	0.418													A	26734241	A	A	26734241	4	1	133	1	0	0	0	0	0	1	0	0	14664	1153	40	1	1560	1	SLC5A12	11	26734241	Nonsense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	24553159	26734241	108272275	54	9208											
LRRC4C	57689	broad.mit.edu	37	chr11	40135944	40135944	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atttgagtctcttgtacattGtctttagagttcattcggat	8	6	3	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr11:40135944G>T	uc001mxa.1	-	2	3863	c.1899C>A	c.(1897-1899)GAC>GAA	p.D633E	LRRC4C_uc001mxc.1_Missense_Mutation_p.D629E|LRRC4C_uc001mxd.1_Missense_Mutation_p.D629E|LRRC4C_uc001mxb.1_Missense_Mutation_p.D629E	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	633					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CTTGTACATTGTCTTTAGAGT	0.274													T	40135944	T	T	40135944	3	4	133	1	0	0	0	0	1	0	0	0	9008	1368	48	5	27	5	LRRC4C	11	40135944	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	13401703	40135944	94870572	55	9209											
OR5AR1	219493	broad.mit.edu	37	chr11	56431699	56431699	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcatcaatcatttcttctgcGaaatcccaccactcttggcc	4	15	6	0	rs138342920		TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr11:56431699G>A	uc010rjm.1	+	1	538	c.538G>A	c.(538-540)GAA>AAA	p.E180K		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTCTTCTGCGAAATCCCACC	0.483													A	56431699	A	A	56431699	3	1	133	1	0	0	0	0	1	0	0	0	11145	1059	37	2	540	2	OR5AR1	11	56431699	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	16295755	56431699	78574817	56	9210											
OR9G4	283189	broad.mit.edu	37	chr11	56511283	56511283	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gactatcatgagaagggaaaAtcatcacttagtgttttttc	8	6	3	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr11:56511283A>T	uc010rjo.1	-	1	5	c.5T>A	c.(4-6)ATT>AAT	p.I2N		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						AGAAGGGAAAATCATCACTTA	0.383													T	56511283	T	T	56511283	3	4	133	1	0	0	0	0	1	0	0	0	11251	101	4	5	981	5	OR9G4	11	56511283	Missense_Mutation	SNP	A	TCGA-14-0817-01A-01W-0424-08	79584	56511283	78495233	57	9211											
OR4D6	219983	broad.mit.edu	37	chr11	59224665	59224665	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgttttttcatctatcaccGtccccaagttcctggtggat	7	12	3	0	rs144983296	by1000genomes	TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr11:59224665G>A	uc010rku.1	+	1	232	c.232G>A	c.(232-234)GTC>ATC	p.V78I		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	78	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCTATCACCGTCCCCAAGTT	0.468													A	59224665	A	A	59224665	3	1	133	1	0	0	0	0	1	0	0	0	11058	1145	40	1	234	1	OR4D6	11	59224665	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	2713382	59224665	75781851	58	9212											
ARHGEF17	9828	broad.mit.edu	37	chr11	73073628	73073628	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacatctccattgcaggctcGggcttggagatgacgccggg	14	12	1	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr11:73073628G>A	uc001otu.2	+	14	4866	c.4845G>A	c.(4843-4845)TCG>TCA	p.S1615S		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1615					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						TTGCAGGCTCGGGCTTGGAGA	0.706													A	73073628	A	A	73073628	2	1	133	1	0	0	0	0	0	0	0	1	900	1103	39	2		2	ARHGEF17	11	73073628	Silent	SNP	G	TCGA-14-0817-01A-01W-0424-08	13848963	73073628	61932888	59	9213											
ODZ4	26011	broad.mit.edu	37	chr11	78383335	78383335	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatcttctctgtgcgtgttaCgcgatcaaagtccagagata	10	9	3	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr11:78383335C>T	uc001ozl.3	-	31	5999	c.5536G>A	c.(5536-5538)GTA>ATA	p.V1846I	ODZ4_uc001ozk.3_Missense_Mutation_p.V71I|ODZ4_uc009yvb.1_Missense_Mutation_p.V430I	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1846	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GTGCGTGTTACGCGATCAAAG	0.512													T	78383335	T	T	78383335	3	4	133	1	0	0	0	0	1	0	0	0	10837	536	19	1	2789	1	ODZ4	11	78383335	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	5309707	78383335	56623181	60	9214											
PZP	5858	broad.mit.edu	37	chr12	9346769	9346769	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcattggagtaataattggcGtcattcacagagatgaagaa	11	5	2	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr12:9346769G>A	uc001qvl.2	-	11	1187	c.1158C>T	c.(1156-1158)GAC>GAT	p.D386D	PZP_uc009zgl.2_Silent_p.D255D	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AATAATTGGCGTCATTCACAG	0.408													A	9346769	A	A	9346769	2	1	133	1	0	0	0	0	0	0	0	1	12869	1136	40	1		1	PZP	12	9346769	Silent	SNP	G	TCGA-14-0817-01A-01W-0424-08		9346769	124505126	61	9215											
NR1H4	9971	broad.mit.edu	37	chr12	100897268	100897268	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatgatgagtatgaagcccGcgaaaggtaggacactgttc	12	7	0	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr12:100897268G>A	uc001tht.1	+	1	131	c.103G>A	c.(103-105)GCG>ACG	p.A35T	NR1H4_uc001thp.1_Intron|NR1H4_uc001thq.1_Intron|NR1H4_uc010svj.1_Intron|NR1H4_uc001thr.1_Intron|NR1H4_uc010svk.1_Intron|NR1H4_uc001ths.1_Missense_Mutation_p.A35T	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	35					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TATGAAGCCCGCGAAAGGTAG	0.463													A	100897268	A	A	100897268	3	1	133	1	0	0	0	0	1	0	0	0	10619	1102	38	1		1	NR1H4	12	100897268	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	91550499	100897268	32954627	62	9216											
RBM19	9904	broad.mit.edu	37	chr12	114377904	114377904	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtctcctgcagctgggccGccagggtgcctgccgggagg	18	13	1	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr12:114377904G>A	uc009zwi.2	-	15	1943	c.1799C>T	c.(1798-1800)GCG>GTG	p.A600V	RBM19_uc001tvn.3_Missense_Mutation_p.A600V|RBM19_uc001tvm.2_Missense_Mutation_p.A600V	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	600	RRM 4.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					CAGCTGGGCCGCCAGGGTGCC	0.627													A	114377904	A	A	114377904	3	1	133	1	0	0	0	0	1	0	0	0	13121	1087	38	1	1123	1	RBM19	12	114377904	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	13480636	114377904	19473991	63	9217											
CKAP2	26586	broad.mit.edu	37	chr13	53029668	53029668	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttggcgctaaagcggagaCgcatcccccgacccgaggct	12	15	1	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr13:53029668C>T	uc001vgv.2	+	1	174	c.-23C>T	c.(-25--21)GACGC>GATGC		CKAP2_uc001vgt.2_Translation_Start_Site|CKAP2_uc001vgu.2_Translation_Start_Site|CKAP2_uc010tha.1_5'Flank	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2						apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		AAAGCGGAGACGCATCCCCCG	0.662													T	53029668	T	T	53029668	1	4	133	1	0	0	0	0	0	0	0	0	3442	551	19	1		1	CKAP2	13	53029668	Translation_Start_Site	SNP	C	TCGA-14-0817-01A-01W-0424-08		53029668	62140210	64	9218											
SLC7A8	23428	broad.mit.edu	37	chr14	23600746	23600746	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cactgggaaggtggccctctCgggctccagcgaagaacagc	14	13	1	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr14:23600746C>T	uc001wiz.2	-	8	1763	c.1037G>A	c.(1036-1038)CGA>CAA	p.R346Q	SLC7A8_uc001wiw.2_5'Flank|SLC7A8_uc001wix.2_Missense_Mutation_p.R143Q|SLC7A8_uc010tnk.1_Missense_Mutation_p.R122Q|SLC7A8_uc010tnl.1_Missense_Mutation_p.R241Q|SLC7A8_uc001wiy.2_RNA|SLC7A8_uc010akj.2_Intron	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	346					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	GTGGCCCTCTCGGGCTCCAGC	0.592													T	23600746	T	T	23600746	3	4	133	1	0	0	0	0	1	0	0	0	14704	884	31	2	586	2	SLC7A8	14	23600746	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08		23600746	83748794	65	9219											
SPTB	6710	broad.mit.edu	37	chr14	65261276	65261276	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gcttccatcaacttgtgcttCtgtagcaggtcttcaacctc	7	13	4	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr14:65261276C>T	uc001xht.2	-	12	1758	c.1704G>A	c.(1702-1704)CAG>CAA	p.Q568Q	SPTB_uc001xhr.2_Silent_p.Q568Q|SPTB_uc001xhs.2_Silent_p.Q568Q|SPTB_uc001xhu.2_Silent_p.Q568Q	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	568	Spectrin 3.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		ACTTGTGCTTCTGTAGCAGGT	0.522													T	65261276	T	T	65261276	2	4	133	1	0	0	0	0	0	0	0	1	15117	912	32	3		3	SPTB	14	65261276	Silent	SNP	C	TCGA-14-0817-01A-01W-0424-08	41660530	65261276	42088264	66	9220											
EXD2	55218	broad.mit.edu	37	chr14	69702870	69702870	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctggacaaaggcattggtgGtatgagattcagctgtcctt	12	8	1	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr14:69702870G>T	uc001xkt.2	+	8	1440	c.781_splice	c.e8+1	p.E261_splice	EXD2_uc001xku.2_Splice_Site_p.E131_splice|EXD2_uc001xkv.2_Splice_Site_p.E386_splice|EXD2_uc001xkw.2_Splice_Site_p.E261_splice|EXD2_uc010aqt.2_Splice_Site_p.E386_splice|EXD2_uc010tte.1_Splice_Site_p.E386_splice|EXD2_uc001xky.2_Splice_Site_p.E261_splice	NM_018199	NP_060669	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						GGCATTGGTGGTATGAGATTC	0.478													T	69702870	T	T	69702870	5	4	133	1	0	0	0	0	0	0	1	0	5298	1275	44	5	796	5	EXD2	14	69702870	Splice_Site	SNP	G	TCGA-14-0817-01A-01W-0424-08	4441594	69702870	37646670	67	9221											
CAPN3	825	broad.mit.edu	37	chr15	42700426	42700426	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcccatcatcttcgtttcGgacagagcaaacagcaacaa	7	13	2	1	rs28364528	byFrequency	TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr15:42700426G>A	uc001zpn.1	+	16	2124	c.1818G>A	c.(1816-1818)TCG>TCA	p.S606S	CAPN3_uc001zpk.1_Silent_p.S373S|CAPN3_uc001zpl.1_Silent_p.S513S|CAPN3_uc010udf.1_Silent_p.S519S|CAPN3_uc010udg.1_Silent_p.S471S|CAPN3_uc001zpo.1_Silent_p.S600S|CAPN3_uc001zpp.1_Intron|CAPN3_uc001zpq.1_Silent_p.S94S|CAPN3_uc010bcv.1_Intron|CAPN3_uc001zpr.1_5'UTR|CAPN3_uc001zps.1_Intron|CAPN3_uc001zpt.1_Intron	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	606	Linker.		S -> L (in LGMD2A).		muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		TCTTCGTTTCGGACAGAGCAA	0.532													A	42700426	A	A	42700426	2	1	133	1	0	0	0	0	0	0	0	1	2628	1103	39	2		2	CAPN3	15	42700426	Silent	SNP	G	TCGA-14-0817-01A-01W-0424-08		42700426	59830966	68	9222											
GOLGA6B	55889	broad.mit.edu	37	chr15	72954655	72954655	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaacagctacaagatgagGccaaacacctgaggcaggag	13	9	0	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr15:72954655G>A	uc010uks.1	+	11	951	c.910G>A	c.(910-912)GCC>ACC	p.A304T		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	304	Potential.										0						ACAAGATGAGGCCAAACACCT	0.542													A	72954655	A	A	72954655	3	1	133	1	0	0	0	0	1	0	0	0	6558	1203	42	3	952	3	GOLGA6B	15	72954655	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	30254229	72954655	29576737	69	9223											
ACAN	176	broad.mit.edu	37	chr15	89391161	89391161	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gataccccattgtgagccccCggaccccatgcgtgggtgac	12	15	0	2	rs143697605	by1000genomes	TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr15:89391161C>T	uc010upo.1	+	9	1998	c.1624C>T	c.(1624-1626)CGG>TGG	p.R542W	ACAN_uc002bmx.2_Missense_Mutation_p.R542W|ACAN_uc010upp.1_Missense_Mutation_p.R542W|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	542					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGTGAGCCCCCGGACCCCATG	0.607													T	89391161	T	T	89391161	3	4	133	1	0	0	0	0	1	0	0	0	117	643	23	2	1654	2	ACAN	15	89391161	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	16436506	89391161	13140231	70	9224											
ACAN	176	broad.mit.edu	37	chr15	89401858	89401858	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttgccagcaccaccaatgtAagtggagaatcctctgtagc	9	11	1	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr15:89401858A>G	uc010upo.1	+	12	6416	c.6042A>G	c.(6040-6042)GTA>GTG	p.V2014V	ACAN_uc010upp.1_Silent_p.V2014V|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2014					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCACCAATGTAAGTGGAGAAT	0.522													G	89401858	G	G	89401858	2	3	133	1	0	0	0	0	0	0	0	1	117	349	13	4		4	ACAN	15	89401858	Silent	SNP	A	TCGA-14-0817-01A-01W-0424-08	10697	89401858	13129534	71	9225											
TP53	7157	broad.mit.edu	37	chr17	7578264	7578268	+	Frame_Shift_Del	DEL	GATAA	-	-													cgcaaatttccttccactcgGataagatgctgaggaggggc							TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr17:7578264_7578268delGATAA	uc002gim.2	-	6	775_779	c.581_585delTTATC	c.(580-585)CTTATCfs	p.L194fs	TP53_uc002gig.1_Frame_Shift_Del_p.L194fs|TP53_uc002gih.2_Frame_Shift_Del_p.L194fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.L62fs|TP53_uc010cng.1_Frame_Shift_Del_p.L62fs|TP53_uc002gii.1_Frame_Shift_Del_p.L62fs|TP53_uc010cnh.1_Frame_Shift_Del_p.L194fs|TP53_uc010cni.1_Frame_Shift_Del_p.L194fs|TP53_uc002gij.2_Frame_Shift_Del_p.L194fs|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Frame_Shift_Del_p.L101fs|TP53_uc002gio.2_Frame_Shift_Del_p.L62fs|TP53_uc010vug.1_Frame_Shift_Del_p.L155fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	194_195	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> F (in sporadic cancers; somatic mutation).|I -> L (in a sporadic cancer; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> T (in sporadic cancers; somatic mutation).|I -> V (in a sporadic cancer; somatic mutation).|I -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|I -> N (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I195T(61)|p.L194R(31)|p.L194F(16)|p.I195F(16)|p.I195N(12)|p.L194P(8)|p.R196*(7)|p.0?(7)|p.L194H(5)|p.L194L(4)|p.I195S(4)|p.A189_V197delAPPQHLIRV(4)|p.I195fs*14(3)|p.P191fs*53(2)|p.L194fs*15(2)|p.I195fs*52(2)|p.K164_P219del(1)|p.L194V(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.I195fs*12(1)|p.I195L(1)|p.I195fs*50(1)|p.L194fs*14(1)|p.L194fs*52(1)|p.?(1)|p.I195_G199delIRVEG(1)|p.A189fs*53(1)|p.L194I(1)|p.H193_I195>AP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTCCACTCGGATAAGATGCTGAGG	0.551		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			-	7578268	-	-	7578264	7	5	133	1	0	1	0	1	0	0	0	0	16378	1164	41	0	709	0	TP53	17	7578264	Frame_Shift_Del	DEL	GATAA	TCGA-14-0817-01A-01W-0424-08		7578264	73616946	72	9226											
MYH2	4620	broad.mit.edu	37	chr17	10447064	10447064	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcattcctcacggtcttggcGttgccaaaggcctccagtag	10	13	3	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr17:10447064G>A	uc010coi.2	-	8	833	c.705C>T	c.(703-705)AAC>AAT	p.N235N	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.N235N|MYH2_uc010coj.2_Silent_p.N235N	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	235	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CGGTCTTGGCGTTGCCAAAGG	0.478													A	10447064	A	A	10447064	2	1	133	1	0	0	0	0	0	0	0	1	10035	1136	40	1		1	MYH2	17	10447064	Silent	SNP	G	TCGA-14-0817-01A-01W-0424-08	2868800	10447064	70748146	73	9227											
HOXB3	3213	broad.mit.edu	37	chr17	46628102	46628102	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcgtaggcattctggtggGctttaccgaaggcgggtggg	19	8	1	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr17:46628102G>A	uc002inn.2	-	2	1290	c.890C>T	c.(889-891)GCC>GTC	p.A297V	HOXB3_uc010wlm.1_Missense_Mutation_p.A224V|HOXB3_uc010dbf.2_Missense_Mutation_p.A297V|HOXB3_uc010dbg.2_Missense_Mutation_p.A297V|HOXB3_uc002ino.2_Missense_Mutation_p.A297V|HOXB3_uc010wlk.1_Missense_Mutation_p.A165V|HOXB3_uc010wll.1_Missense_Mutation_p.A224V	NM_002146	NP_002137	P14651	HXB3_HUMAN	homeobox B3	297					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ATTCTGGTGGGCTTTACCGAA	0.672											OREG0024516	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	46628102	A	A	46628102	3	1	133	1	0	0	0	0	1	0	0	0	7302	1203	42	3	409	3	HOXB3	17	46628102	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	36181038	46628102	34567108	74	9228											
EPB41L3	23136	broad.mit.edu	37	chr18	5428401	5428401	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatctgtttattcgcagccGgtcgcgatatatcaacagac	8	10	2	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr18:5428401G>A	uc002kmt.1	-	9	1062	c.976C>T	c.(976-978)CGG>TGG	p.R326W	EPB41L3_uc010wzh.1_Missense_Mutation_p.R326W|EPB41L3_uc002kmu.1_Missense_Mutation_p.R326W|EPB41L3_uc010dkq.1_Missense_Mutation_p.R217W|EPB41L3_uc010dks.1_Missense_Mutation_p.R348W	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	326	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						ATTCGCAGCCGGTCGCGATAT	0.418													A	5428401	A	A	5428401	3	1	133	1	0	0	0	0	1	0	0	0	5154	1115	39	2	2343	2	EPB41L3	18	5428401	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08		5428401	72648847	75	9229											
DSG3	1830	broad.mit.edu	37	chr18	29038467	29038467	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	cgaatctctggagtgggaatCgatcagccgccttttggaat	12	9	2	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr18:29038467C>A	uc002kws.2	+	4	385	c.276C>A	c.(274-276)ATC>ATA	p.I92I		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	92	Extracellular (Potential).|Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GAGTGGGAATCGATCAGCCGC	0.438													A	29038467	A	A	29038467	2	1	133	1	0	0	0	0	0	0	0	1	4778	874	31	5		5	DSG3	18	29038467	Silent	SNP	C	TCGA-14-0817-01A-01W-0424-08	23610066	29038467	49038781	76	9230											
QTRT1	81890	broad.mit.edu	37	chr19	10823297	10823297	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgactgcgtcttccccacacGgacagcggtgaggctctggc	13	15	2	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr19:10823297G>A	uc002mpr.2	+	7	879	c.854G>A	c.(853-855)CGG>CAG	p.R285Q	DNM2_uc010dxk.2_5'Flank	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	285					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			TTCCCCACACGGACAGCGGTG	0.632													A	10823297	A	A	10823297	3	1	133	1	0	0	0	0	1	0	0	0	12885	1116	39	2	880	2	QTRT1	19	10823297	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08		10823297	48305686	77	9231											
PLCB4	5332	broad.mit.edu	37	chr20	9370528	9370528	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttttttgtttttaaaggaTgtaattcaagccatcaagga	7	4	2	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr20:9370528T>C	uc002wnf.2	+	15	1297	c.1161T>C	c.(1159-1161)GAT>GAC	p.D387D	PLCB4_uc010gbw.1_Silent_p.D387D|PLCB4_uc010gbx.2_Silent_p.D387D|PLCB4_uc002wne.2_Silent_p.D387D|PLCB4_uc002wnh.2_Silent_p.D234D	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	387	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						TTTTAAAGGATGTAATTCAAG	0.333													C	9370528	C	C	9370528	2	2	133	1	0	0	0	0	0	0	0	1	12030	1461	51	4		4	PLCB4	20	9370528	Silent	SNP	T	TCGA-14-0817-01A-01W-0424-08		9370528	53654992	78	9232											
WFDC3	140686	broad.mit.edu	37	chr20	44417585	44417585	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catacccttaggaatgtctcGgcagatccgaccacagcctg	9	14	1	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr20:44417585G>A	uc002xpf.1	-	3	280	c.196C>T	c.(196-198)CGA>TGA	p.R66*	DNTTIP1_uc002xpk.2_5'Flank|WFDC3_uc002xpj.1_RNA|WFDC3_uc002xph.1_RNA|WFDC3_uc010ghh.1_Intron	NM_080614	NP_542181	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3 precursor	66	WAP 1.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GGAATGTCTCGGCAGATCCGA	0.527													A	44417585	A	A	44417585	4	1	133	1	0	0	0	0	0	1	0	0	17350	1124	39	2	519	2	WFDC3	20	44417585	Nonsense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	35047057	44417585	18607935	79	9233											
ZBP1	81030	broad.mit.edu	37	chr20	56191402	56191402	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggagactttcaactccttttTcattcggtagaggacttggt	10	8	2	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr20:56191402T>G	uc002xyo.2	-	2	438	c.157A>C	c.(157-159)AAA>CAA	p.K53Q	ZBP1_uc010gjm.2_Missense_Mutation_p.K53Q|ZBP1_uc002xyp.2_Intron|ZBP1_uc010zzn.1_Missense_Mutation_p.K53Q	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	53	DRADA 1.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			AACTCCTTTTTCATTCGGTAG	0.597													G	56191402	G	G	56191402	3	3	133	1	0	0	0	0	1	0	0	0	17518	1792	62	5	1237	5	ZBP1	20	56191402	Missense_Mutation	SNP	T	TCGA-14-0817-01A-01W-0424-08	11773817	56191402	6834118	80	9234											
RIPK4	54101	broad.mit.edu	37	chr21	43161460	43161460	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgccagcaggctgcagacGttgacgtcggagcacaggtc	15	11	0	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr21:43161460G>A	uc002yzn.1	-	8	1941	c.1893C>T	c.(1891-1893)AAC>AAT	p.N631N		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	631						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GGCTGCAGACGTTGACGTCGG	0.697													A	43161460	A	A	43161460	2	1	133	1	0	0	0	0	0	0	0	1	13383	1136	40	1		1	RIPK4	21	43161460	Silent	SNP	G	TCGA-14-0817-01A-01W-0424-08		43161460	4968435	81	9235											
MCM5	4174	broad.mit.edu	37	chr22	35796511	35796511	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccgacgaggggcaggcccGcaaatcgcagctgcagaggc	17	13	0	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr22:35796511G>A	uc003anu.3	+	2	174	c.80G>A	c.(79-81)CGC>CAC	p.R27H	MCM5_uc010gwr.2_5'UTR|MCM5_uc003anv.3_Missense_Mutation_p.R27H	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	27					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						GGGCAGGCCCGCAAATCGCAG	0.647													A	35796511	A	A	35796511	3	1	133	1	0	0	0	0	1	0	0	0	9390	1087	38	1	82	1	MCM5	22	35796511	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08		35796511	15508055	82	9236											
APOBEC3H	164668	broad.mit.edu	37	chr22	39497965	39497965	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttgtggaccacgagaaacCgctttccttcaacccctata	6	14	1	1			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr22:39497965C>T	uc011aoh.1	+	4	527	c.461C>T	c.(460-462)CCG>CTG	p.P154L	APOBEC3H_uc011aoi.1_RNA|APOBEC3H_uc003axa.3_RNA	NM_181773	NP_861438	Q6NTF7	ABC3H_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	154					DNA cytosine deamination|negative regulation of retroviral genome replication|negative regulation of transposition	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Melanoma(58;0.04)					CACGAGAAACCGCTTTCCTTC	0.537													T	39497965	T	T	39497965	3	4	133	1	0	0	0	0	1	0	0	0	795	652	23	2	471	2	APOBEC3H	22	39497965	Missense_Mutation	SNP	C	TCGA-14-0817-01A-01W-0424-08	3701454	39497965	11806601	83	9237											
CENPM	79019	broad.mit.edu	37	chr22	42342475	42342475	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcgagtccgccagctgctgcAgaagagcatcctccgtgccc	11	16	0	2			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chr22:42342475A>G	uc003bbn.2	-	2	151	c.83T>C	c.(82-84)CTG>CCG	p.L28P	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|CENPM_uc003bbm.2_5'UTR|CENPM_uc003bbo.2_Missense_Mutation_p.L28P|CENPM_uc003bbp.1_Missense_Mutation_p.L28P	NM_024053	NP_076958	Q9NSP4	CENPM_HUMAN	centromere protein M isoform a	28					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus					0						CAGCTGCTGCAGAAGAGCATC	0.662											OREG0026600	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	42342475	G	G	42342475	3	3	133	1	0	0	0	0	1	0	0	0	3237	188	7	4	519	4	CENPM	22	42342475	Missense_Mutation	SNP	A	TCGA-14-0817-01A-01W-0424-08	2844510	42342475	8962091	84	9238											
PHEX	5251	broad.mit.edu	37	chrX	22151701	22151701	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catgctagagaaagaaaatgAgtggatggatgcaggaacga	14	4	0	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chrX:22151701A>T	uc004dah.2	+	12	1567	c.1364A>T	c.(1363-1365)GAG>GTG	p.E455V	PHEX_uc011mjr.1_Missense_Mutation_p.E455V|PHEX_uc011mjs.1_Missense_Mutation_p.E358V	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	455	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						AAAGAAAATGAGTGGATGGAT	0.403													T	22151701	T	T	22151701	3	4	133	1	0	0	0	0	1	0	0	0	11819	304	11	5	1410	5	PHEX	23	22151701	Missense_Mutation	SNP	A	TCGA-14-0817-01A-01W-0424-08		22151701	133118859	85	9239											
GLUD2	2747	broad.mit.edu	37	chrX	120183085	120183085	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttggcatacacaatggagcGttctgccaggcaaattatgc	10	10	1	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chrX:120183085G>A	uc004eto.2	+	1	1624	c.1547G>A	c.(1546-1548)CGT>CAT	p.R516H		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	516					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	ACAATGGAGCGTTCTGCCAGG	0.468													A	120183085	A	A	120183085	3	1	133	1	0	0	0	0	1	0	0	0	6477	1145	40	1	1549	1	GLUD2	23	120183085	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	98031384	120183085	35087475	86	9240											
ENOX2	10495	broad.mit.edu	37	chrX	129759413	129759413	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagacactccacatcgctggTgcagatctgtgggacagaga	13	10	1	3			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chrX:129759413T>G	uc004evw.2	-	16	2126	c.1708A>C	c.(1708-1710)ACC>CCC	p.T570P	ENOX2_uc004evx.2_Missense_Mutation_p.T541P|ENOX2_uc004evy.2_Missense_Mutation_p.T541P|ENOX2_uc004evv.2_Missense_Mutation_p.T395P	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	570					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						ACATCGCTGGTGCAGATCTGT	0.463													G	129759413	G	G	129759413	3	3	133	1	0	0	0	0	1	0	0	0	5127	1696	59	5	128	5	ENOX2	23	129759413	Missense_Mutation	SNP	T	TCGA-14-0817-01A-01W-0424-08	9576328	129759413	25511147	87	9241											
SLITRK2	84631	broad.mit.edu	37	chrX	144903994	144903997	+	Frame_Shift_Del	DEL	ACAG	-	-													ttaaccgtggccgggatcttAcagacagagagtcgcaaaac							TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chrX:144903994_144903997delACAG	uc004fcd.2	+	5	1041_1044	c.51_54delACAG	c.(49-54)TTACAGfs	p.L17fs	SLITRK2_uc010nsp.2_Frame_Shift_Del_p.L17fs|SLITRK2_uc010nso.2_Frame_Shift_Del_p.L17fs|SLITRK2_uc011mwq.1_Frame_Shift_Del_p.L17fs|SLITRK2_uc011mwr.1_Frame_Shift_Del_p.L17fs|SLITRK2_uc011mws.1_Frame_Shift_Del_p.L17fs|SLITRK2_uc004fcg.2_Frame_Shift_Del_p.L17fs|SLITRK2_uc011mwt.1_Frame_Shift_Del_p.L17fs	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	17_18						integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCGGGATCTTACAGACAGAGAGTC	0.471													-	144903997	-	-	144903994	7	5	133	1	0	1	0	1	0	0	0	0	14743	388	14	0	53	0	SLITRK2	23	144903994	Frame_Shift_Del	DEL	ACAG	TCGA-14-0817-01A-01W-0424-08	15144581	144903994	10366566	88	9242											
L1CAM	3897	broad.mit.edu	37	chrX	153137805	153137805	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacaccatccctcgtccagcGgaacctgtgggcggaaaaag	12	13	0	0			TCGA-14-0817-01A-01W-0424-08	TCGA-14-0817-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	a5f06dfc-e9b2-46a6-bee5-604d2839baad	718c8867-1636-4bdd-8838-459ea6e73080	g.chrX:153137805G>A	uc004fjb.2	-	4	310	c.202C>T	c.(202-204)CGC>TGC	p.R68C	L1CAM_uc004fjc.2_Missense_Mutation_p.R68C|L1CAM_uc010nuo.2_Missense_Mutation_p.R63C|L1CAM_uc004fjd.1_5'Flank|L1CAM_uc004fje.1_Missense_Mutation_p.R63C	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	68	Extracellular (Potential).|Ig-like C2-type 1.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTCGTCCAGCGGAACCTGTGG	0.637													A	153137805	A	A	153137805	3	1	133	1	0	0	0	0	1	0	0	0	8588	1116	39	2	3671	2	L1CAM	23	153137805	Missense_Mutation	SNP	G	TCGA-14-0817-01A-01W-0424-08	8233811	153137805	2132755	89	9243											
FLG2	388698	broad.mit.edu	37	chr1	152326384	152326384	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtgagatccagcttgtgtgTgaatgtgttctgaatgtctg	13	5	2	3			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr1:152326384T>C	uc001ezw.3	-	3	3951	c.3878A>G	c.(3877-3879)CAC>CGC	p.H1293R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1293							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTTGTGTGTGAATGTGTTC	0.473													C	152326384	C	C	152326384	3	2	134	1	0	0	0	0	1	0	0	0	5923	1696	59	4	3301	4	FLG2	1	152326384	Missense_Mutation	SNP	T	TCGA-14-0862-01B-01D-1845-08		152326384	96924237	1	9244											
HHIPL2	79802	broad.mit.edu	37	chr1	222717002	222717002	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatagaacttgcgattgtggCggaatttggggtgaaaagcc	14	5	0	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr1:222717002C>T	uc001hnh.1	-	2	909	c.851G>A	c.(850-852)CGC>CAC	p.R284H		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	284					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GCGATTGTGGCGGAATTTGGG	0.483													T	222717002	T	T	222717002	3	4	134	1	0	0	0	0	1	0	0	0	7094	768	27	1	1355	1	HHIPL2	1	222717002	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	70390618	222717002	26533619	2	9245											
PELI1	57162	broad.mit.edu	37	chr2	64323378	64323378	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaacccattgcgtggatgcaTcacaagaacaccattagtgg	10	10	1	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr2:64323378T>C	uc002scs.3	-	5	4610	c.571A>G	c.(571-573)ATG>GTG	p.M191V	PELI1_uc002sct.3_Missense_Mutation_p.M191V|PELI1_uc002scr.3_Missense_Mutation_p.M12V	NM_020651	NP_065702	Q96FA3	PELI1_HUMAN	pellino protein	191					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				ovary(1)	1						CGTGGATGCATCACAAGAACA	0.458													C	64323378	C	C	64323378	3	2	134	1	0	0	0	0	1	0	0	0	11721	1435	50	4	693	4	PELI1	2	64323378	Missense_Mutation	SNP	T	TCGA-14-0862-01B-01D-1845-08		64323378	178875995	3	9246											
ARHGAP25	9938	broad.mit.edu	37	chr2	69053291	69053291	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagaagaagtcaaggaatttGtcaaatccatgaaggaaccc	9	7	2	3			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr2:69053291G>A	uc002seu.2	+	11	2267	c.1903G>A	c.(1903-1905)GTC>ATC	p.V635I	ARHGAP25_uc010fdg.2_Missense_Mutation_p.V636I|ARHGAP25_uc010yql.1_Missense_Mutation_p.V596I|ARHGAP25_uc002sew.2_Missense_Mutation_p.V628I|ARHGAP25_uc002sex.2_Missense_Mutation_p.V629I|ARHGAP25_uc002sey.2_Missense_Mutation_p.V362I	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	635	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						CAAGGAATTTGTCAAATCCAT	0.552													A	69053291	A	A	69053291	3	1	134	1	0	0	0	0	1	0	0	0	874	1377	48	3	1988	3	ARHGAP25	2	69053291	Missense_Mutation	SNP	G	TCGA-14-0862-01B-01D-1845-08	4729913	69053291	174146082	4	9247											
YSK4	80122	broad.mit.edu	37	chr2	135738921	135738921	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcacagtgttctcttgcaaGcatgtccccaaataggccac	7	14	2	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr2:135738921G>T	uc002tue.1	-	9	3421	c.3390C>A	c.(3388-3390)TGC>TGA	p.C1130*	YSK4_uc002tuf.1_Nonsense_Mutation_p.C312*|YSK4_uc010fnc.1_Nonsense_Mutation_p.C264*|YSK4_uc010fnd.1_Nonsense_Mutation_p.C1017*|YSK4_uc010zbg.1_Nonsense_Mutation_p.C262*|YSK4_uc002tuh.3_Nonsense_Mutation_p.C858*|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1130	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCTCTTGCAAGCATGTCCCCA	0.418													T	135738921	T	T	135738921	4	4	134	1	0	0	0	0	0	1	0	0	17492	963	34	5	604	5	YSK4	2	135738921	Nonsense_Mutation	SNP	G	TCGA-14-0862-01B-01D-1845-08	66685630	135738921	107460452	5	9248											
SAG	6295	broad.mit.edu	37	chr2	234237130	234237130	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgtttcccacaggagctcCgtgcgattactgatccgcaa	10	13	0	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr2:234237130C>T	uc002vuh.2	+	8	907	c.519C>T	c.(517-519)TCC>TCT	p.S173S	SAG_uc010zmq.1_Silent_p.S39S	NM_000541	NP_000532	P10523	ARRS_HUMAN	S-arrestin	173					rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			ovary(1)	1		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)		ACAGGAGCTCCGTGCGATTAC	0.592													T	234237130	T	T	234237130	2	4	134	1	0	0	0	0	0	0	0	1	13808	639	23	2		2	SAG	2	234237130	Silent	SNP	C	TCGA-14-0862-01B-01D-1845-08	98498209	234237130	8962243	6	9249											
NEK4	6787	broad.mit.edu	37	chr3	52780805	52780807	+	In_Frame_Del	DEL	CTC	-	-													ctctgtgctcagtctgttctCtcctcttttgccgtcgctgt							TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr3:52780805_52780807delCTC	uc003dfq.3	-	9	1809_1811	c.1620_1622delGAG	c.(1618-1623)AGGAGA>AGA	p.540_541RR>R	NEK4_uc011bej.1_In_Frame_Del_p.451_452RR>R|NEK4_uc003dfr.2_In_Frame_Del_p.494_495RR>R	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	540_541					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		AGTCTGTTCTCTCCTCTTTTGCC	0.483													-	52780807	-	-	52780805	7	5	134	1	0	1	0	1	0	0	0	0	10326	913	32	0	935	0	NEK4	3	52780805	In_Frame_Del	DEL	CTC	TCGA-14-0862-01B-01D-1845-08		52780805	145241625	7	9250											
PRKCD	5580	broad.mit.edu	37	chr3	53222823	53222823	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaaagagaacatattcggGgagagccgggccagcacctt	13	10	0	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr3:53222823G>A	uc003dgl.2	+	16	1856	c.1503G>A	c.(1501-1503)GGG>GGA	p.G501G	PRKCD_uc003dgm.2_Silent_p.G501G	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	501	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		ACATATTCGGGGAGAGCCGGG	0.552													A	53222823	A	A	53222823	2	1	134	1	0	0	0	0	0	0	0	1	12509	1219	43	3		3	PRKCD	3	53222823	Silent	SNP	G	TCGA-14-0862-01B-01D-1845-08	442018	53222823	144799607	8	9251											
HHLA2	11148	broad.mit.edu	37	chr3	108076824	108076824	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actttctctgtcctggcttaCtatctgagctcctcacaaaa	5	13	3	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr3:108076824C>T	uc003dwy.3	+	6	986	c.819C>T	c.(817-819)TAC>TAT	p.Y273Y	HHLA2_uc011bhl.1_Silent_p.Y209Y|HHLA2_uc010hpu.2_Silent_p.Y273Y|HHLA2_uc003dwz.2_Silent_p.Y273Y	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	273	Ig-like V-type 2.					integral to membrane				ovary(1)	1						TCCTGGCTTACTATCTGAGCT	0.383													T	108076824	T	T	108076824	2	4	134	1	0	0	0	0	0	0	0	1	7095	576	20	3		3	HHLA2	3	108076824	Silent	SNP	C	TCGA-14-0862-01B-01D-1845-08	54854001	108076824	89945606	9	9252											
PKD2	5311	broad.mit.edu	37	chr4	88973174	88973174	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctataggaattaacatatAcagaacatcaaatgtggagg	9	5	1	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr4:88973174A>G	uc003hre.2	+	7	1646	c.1580A>G	c.(1579-1581)TAC>TGC	p.Y527C	PKD2_uc011cdf.1_Translation_Start_Site|PKD2_uc011cdg.1_Translation_Start_Site|PKD2_uc011cdh.1_Translation_Start_Site	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	527	Extracellular (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		ATTAACATATACAGAACATCA	0.328													G	88973174	G	G	88973174	3	3	134	1	0	0	0	0	1	0	0	0	11966	391	14	4	1606	4	PKD2	4	88973174	Missense_Mutation	SNP	A	TCGA-14-0862-01B-01D-1845-08		88973174	102181102	10	9253											
POU4F2	5458	broad.mit.edu	37	chr4	147561831	147561831	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaagcctactttgccattcaGcctcggccctcctctgaaaa	7	15	2	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr4:147561831G>T	uc003ikv.2	+	2	1349	c.1101G>T	c.(1099-1101)CAG>CAT	p.Q367H		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	367	Homeobox.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					TTGCCATTCAGCCTCGGCCCT	0.582													T	147561831	T	T	147561831	3	4	134	1	0	0	0	0	1	0	0	0	12279	962	34	5	1107	5	POU4F2	4	147561831	Missense_Mutation	SNP	G	TCGA-14-0862-01B-01D-1845-08	58588657	147561831	43592445	11	9254											
TLR2	7097	broad.mit.edu	37	chr4	154624496	154624496	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aggggaaacatctcttttttCtcatctcacaaaattgcaaa	5	9	3	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr4:154624496C>G	uc003inq.2	+	3	656	c.437C>G	c.(436-438)TCT>TGT	p.S146C	TLR2_uc003inr.2_Missense_Mutation_p.S146C|TLR2_uc003ins.2_Missense_Mutation_p.S146C	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	146	LRR 4.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				TCTCTTTTTTCTCATCTCACA	0.373													G	154624496	G	G	154624496	3	3	134	1	0	0	0	0	1	0	0	0	15948	913	32	5	439	5	TLR2	4	154624496	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	7062665	154624496	36529780	12	9255											
PIK3R1	5295	broad.mit.edu	37	chr5	67589149	67589149	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggaaagggggaaataacaaAttaatcaaaatatttcatcg	8	4	2	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr5:67589149A>T	uc003jva.2	+	10	1697	c.1137A>T	c.(1135-1137)AAA>AAT	p.K379N	PIK3R1_uc003jvb.2_Missense_Mutation_p.K379N|PIK3R1_uc003jvc.2_Missense_Mutation_p.K79N|PIK3R1_uc003jvd.2_Missense_Mutation_p.K109N|PIK3R1_uc003jve.2_Missense_Mutation_p.K58N|PIK3R1_uc011crb.1_Missense_Mutation_p.K49N	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	379	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GAAATAACAAATTAATCAAAA	0.308			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			T	67589149	T	T	67589149	3	4	134	1	0	0	0	0	1	0	0	0	11918	98	4	5	1301	5	PIK3R1	5	67589149	Missense_Mutation	SNP	A	TCGA-14-0862-01B-01D-1845-08		67589149	113326111	13	9256											
CXXC5	51523	broad.mit.edu	37	chr5	139060958	139060958	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agtgcagcagttgtaggaatCgaaagactggccatcagatt	12	7	1	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr5:139060958C>T	uc010jfg.1	+	2	1140	c.850C>T	c.(850-852)CGA>TGA	p.R284*	CXXC5_uc003let.2_Nonsense_Mutation_p.R284*	NM_016463	NP_057547	Q7LFL8	CXXC5_HUMAN	CXXC finger 5	284	CXXC-type.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTAGGAATCGAAAGACTGG	0.562													T	139060958	T	T	139060958	4	4	134	1	0	0	0	0	0	1	0	0	4099	876	31	2	852	2	CXXC5	5	139060958	Nonsense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	71471809	139060958	41854302	14	9257											
PCDHB12	56124	broad.mit.edu	37	chr5	140590067	140590067	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgcaggggttccagttcCgcgtgggcgccacagaccac	13	16	0	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr5:140590067C>T	uc003liz.2	+	1	1777	c.1588C>T	c.(1588-1590)CGC>TGC	p.R530C	PCDHB12_uc011dak.1_Missense_Mutation_p.R193C	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	530	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCCAGTTCCGCGTGGGCGC	0.677													T	140590067	T	T	140590067	3	4	134	1	0	0	0	0	1	0	0	0	11537	652	23	2	1590	2	PCDHB12	5	140590067	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	1529109	140590067	40325193	15	9258											
PCDHGB6	56100	broad.mit.edu	37	chr5	140788951	140788951	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acagacattccattcaagatTtattcttcttccaataacta	2	10	3	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr5:140788951T>G	uc003lkj.1	+	1	1182	c.1182T>G	c.(1180-1182)ATT>ATG	p.I394M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.I394M	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	394	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTCAAGATTTATTCTTCTT	0.453													G	140788951	G	G	140788951	3	3	134	1	0	0	0	0	1	0	0	0	11567	1829	64	5	1184	5	PCDHGB6	5	140788951	Missense_Mutation	SNP	T	TCGA-14-0862-01B-01D-1845-08	198884	140788951	40126309	16	9259											
BMP5	653	broad.mit.edu	37	chr6	55739290	55739290	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgagataactgtatgcgaCgaggatacccattgggagag	13	8	0	2	rs148184427		TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr6:55739290C>T	uc003pcq.2	-	1	1086	c.374G>A	c.(373-375)CGT>CAT	p.R125H	BMP5_uc011dxf.1_Missense_Mutation_p.R125H	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	125					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTGTATGCGACGAGGATACCC	0.522													T	55739290	T	T	55739290	3	4	134	1	0	0	0	0	1	0	0	0	1463	536	19	1	1018	1	BMP5	6	55739290	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08		55739290	115375777	17	9260											
LAMA2	3908	broad.mit.edu	37	chr6	129687471	129687471	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcctgcgccatataaaatgCtgtatggtcttgaaaatatg	9	7	1	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr6:129687471C>T	uc003qbn.2	+	33	4930	c.4825C>T	c.(4825-4827)CTG>TTG	p.L1609L	LAMA2_uc003qbo.2_Silent_p.L1609L	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1609	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATATAAAATGCTGTATGGTCT	0.517													T	129687471	T	T	129687471	2	4	134	1	0	0	0	0	0	0	0	1	8606	796	28	3		3	LAMA2	6	129687471	Silent	SNP	C	TCGA-14-0862-01B-01D-1845-08	73948181	129687471	41427596	18	9261											
CNTNAP2	26047	broad.mit.edu	37	chr7	147914501	147914501	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccagcagaactcccacccGgacctggcacaggaggagat	12	14	0	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr7:147914501G>A	uc003weu.1	+	19	3648	c.3132G>A	c.(3130-3132)CCG>CCA	p.P1044P		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1044	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACTCCCACCCGGACCTGGCAC	0.562										HNSCC(39;0.1)			A	147914501	A	A	147914501	2	1	134	1	0	0	0	0	0	0	0	1	3647	1103	39	2		2	CNTNAP2	7	147914501	Silent	SNP	G	TCGA-14-0862-01B-01D-1845-08		147914501	11224162	19	9262											
ARMC1	55156	broad.mit.edu	37	chr8	66534548	66534548	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atacccagttctcctttcatCttttctctgtttgcacggca	5	13	4	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr8:66534548C>G	uc003xvl.2	-	3	460	c.225G>C	c.(223-225)AAG>AAC	p.K75N	ARMC1_uc011leo.1_Missense_Mutation_p.D37H	NM_018120	NP_060590	Q9NVT9	ARMC1_HUMAN	armadillo repeat-containing protein	75	ARM.				metal ion transport		metal ion binding			skin(1)	1			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			CTCCTTTCATCTTTTCTCTGT	0.338													G	66534548	G	G	66534548	3	3	134	1	0	0	0	0	1	0	0	0	949	912	32	5	643	5	ARMC1	8	66534548	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08		66534548	79829474	20	9263											
OR1L1	26737	broad.mit.edu	37	chr9	125424624	125424624	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggctgtcataatgaccccGttttcatgcatcatcatctc	6	12	5	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr9:125424624G>A	uc011lza.1	+	1	780	c.780G>A	c.(778-780)CCG>CCA	p.P260P		NM_001005236	NP_001005236	Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L,	260	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						TAATGACCCCGTTTTCATGCA	0.413													A	125424624	A	A	125424624	2	1	134	1	0	0	0	0	0	0	0	1	10963	1132	40	1		1	OR1L1	9	125424624	Silent	SNP	G	TCGA-14-0862-01B-01D-1845-08		125424624	15788807	21	9264											
FEZ1	9638	broad.mit.edu	37	chr11	125359436	125359436	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggagctaggttctcggtctTggcgttgtagttccgaaagc	15	8	2	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr11:125359436T>G	uc001qbx.2	-	2	390	c.238A>C	c.(238-240)AAG>CAG	p.K80Q	FEZ1_uc010sbc.1_Missense_Mutation_p.K80Q|FEZ1_uc001qby.1_Missense_Mutation_p.K80Q	NM_005103	NP_005094	Q99689	FEZ1_HUMAN	zygin 1 isoform 1	80					axon guidance|cell adhesion|transport	microtubule|plasma membrane				central_nervous_system(3)|ovary(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		TTCTCGGTCTTGGCGTTGTAG	0.463													G	125359436	G	G	125359436	3	3	134	1	0	0	0	0	1	0	0	0	5823	1821	63	5	980	5	FEZ1	11	125359436	Missense_Mutation	SNP	T	TCGA-14-0862-01B-01D-1845-08		125359436	9647080	22	9265											
VWF	7450	broad.mit.edu	37	chr12	6128780	6128780	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcctgctgcagtagaaatcGtgcaacggcggttccgagat	13	10	0	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr12:6128780G>A	uc001qnn.1	-	28	4054	c.3804C>T	c.(3802-3804)CAC>CAT	p.H1268H	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1268			H -> D (in VWD2).		blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	AGTAGAAATCGTGCAACGGCG	0.617													A	6128780	A	A	6128780	2	1	134	1	0	0	0	0	0	0	0	1	17243	1136	40	1		1	VWF	12	6128780	Silent	SNP	G	TCGA-14-0862-01B-01D-1845-08		6128780	127723115	23	9266											
MON2	23041	broad.mit.edu	37	chr12	62954286	62954286	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tataggagatttttcaagagCttgggatgttcttcttgacc	10	6	3	3			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr12:62954286C>T	uc001sre.2	+	26	3816	c.3425C>T	c.(3424-3426)GCT>GTT	p.A1142V	MON2_uc009zqj.2_Missense_Mutation_p.A1142V|MON2_uc010ssl.1_Missense_Mutation_p.A1070V|MON2_uc010ssm.1_Missense_Mutation_p.A1119V|MON2_uc010ssn.1_Missense_Mutation_p.A1142V|MON2_uc001srf.2_Missense_Mutation_p.A905V|MON2_uc001srg.2_Missense_Mutation_p.A17V	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1143					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTTTCAAGAGCTTGGGATGTT	0.338													T	62954286	T	T	62954286	3	4	134	1	0	0	0	0	1	0	0	0	9700	797	28	3	3527	3	MON2	12	62954286	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	56825506	62954286	70897609	24	9267											
WSCD2	9671	broad.mit.edu	37	chr12	108589646	108589646	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaaattccagcggtacttcCgccggaaacctgtgcgcttc	9	14	1	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr12:108589646C>T	uc001tms.2	+	2	781	c.37C>T	c.(37-39)CGC>TGC	p.R13C	WSCD2_uc001tmt.2_Missense_Mutation_p.R13C	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	13						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GCGGTACTTCCGCCGGAAACC	0.587													T	108589646	T	T	108589646	3	4	134	1	0	0	0	0	1	0	0	0	17404	652	23	2	39	2	WSCD2	12	108589646	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	45635360	108589646	25262249	25	9268											
TCHP	84260	broad.mit.edu	37	chr12	110352296	110352296	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agagaagattgagcagaaccGacgggcacaagaggaatccc	13	9	0	5			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr12:110352296G>A	uc001tpn.2	+	11	1337	c.1184G>A	c.(1183-1185)CGA>CAA	p.R395Q	TCHP_uc001tpo.1_RNA|TCHP_uc001tpp.2_Missense_Mutation_p.R395Q	NM_001143852	NP_001137324	Q9BT92	TCHP_HUMAN	trichoplein	395	Trichohyalin/plectin homology domain.|Glu-rich.|Potential.|Interaction with keratin proteins.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			skin(1)	1						GAGCAGAACCGACGGGCACAA	0.483													A	110352296	A	A	110352296	3	1	134	1	0	0	0	0	1	0	0	0	15699	1058	37	2	1222	2	TCHP	12	110352296	Missense_Mutation	SNP	G	TCGA-14-0862-01B-01D-1845-08	1762650	110352296	23499599	26	9269											
CLIP1	6249	broad.mit.edu	37	chr12	122825886	122825886	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tctccagtttggacttccatAgagctatcacatctgagttc	7	11	3	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr12:122825886A>T	uc001ucg.1	-	10	1971	c.1865T>A	c.(1864-1866)CTA>CAA	p.L622Q	CLIP1_uc001uch.1_Missense_Mutation_p.L611Q|CLIP1_uc001uci.1_Missense_Mutation_p.L576Q|CLIP1_uc001ucj.1_Missense_Mutation_p.L312Q|CLIP1_uc009zxo.1_Missense_Mutation_p.L178Q	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	622	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		GGACTTCCATAGAGCTATCAC	0.488													T	122825886	T	T	122825886	3	4	134	1	0	0	0	0	1	0	0	0	3532	420	15	5	2515	5	CLIP1	12	122825886	Missense_Mutation	SNP	A	TCGA-14-0862-01B-01D-1845-08	12473590	122825886	11026009	27	9270											
OR11H12	440153	broad.mit.edu	37	chr14	19378054	19378054	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctaatatcatgactgggcAtctctgtgccaaactggtca	8	11	3	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr14:19378054A>C	uc010tkp.1	+	1	461	c.461A>C	c.(460-462)CAT>CCT	p.H154P		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	154	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATGACTGGGCATCTCTGTGCC	0.478													C	19378054	C	C	19378054	3	2	134	1	0	0	0	0	1	0	0	0	10927	217	8	5	463	5	OR11H12	14	19378054	Missense_Mutation	SNP	A	TCGA-14-0862-01B-01D-1845-08		19378054	87971486	28	9271											
TMCO5A	145942	broad.mit.edu	37	chr15	38228595	38228595	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catggaccttgaaagggataCgcagagaatagatgaagcaa	12	6	0	4	rs138045481		TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr15:38228595C>T	uc001zjw.2	+	2	174	c.71C>T	c.(70-72)ACG>ATG	p.T24M	TMCO5A_uc001zjv.1_Missense_Mutation_p.T24M|TMCO5A_uc010bbc.1_Missense_Mutation_p.T24M	NM_152453	NP_689666	Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	24	Potential.					integral to membrane				central_nervous_system(1)	1						GAAAGGGATACGCAGAGAATA	0.398													T	38228595	T	T	38228595	3	4	134	1	0	0	0	0	1	0	0	0	15996	536	19	1	73	1	TMCO5A	15	38228595	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08		38228595	64302797	29	9272											
USP8	9101	broad.mit.edu	37	chr15	50788098	50788098	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatgatcatctcgatgacttTaaagctgcagaacatgcctg	8	9	2	3			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr15:50788098T>C	uc001zym.3	+	18	3212	c.2712T>C	c.(2710-2712)TTT>TTC	p.F904F	USP8_uc001zyl.3_Silent_p.F904F|USP8_uc001zyn.3_Silent_p.F904F|USP8_uc010ufh.1_Silent_p.F798F|uc001zyo.1_5'Flank|USP8_uc001zyp.3_Silent_p.F71F	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	904					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TCGATGACTTTAAAGCTGCAG	0.348													C	50788098	C	C	50788098	2	2	134	1	0	0	0	0	0	0	0	1	17086	1751	61	4		4	USP8	15	50788098	Silent	SNP	T	TCGA-14-0862-01B-01D-1845-08	12559503	50788098	51743294	30	9273											
ADCY9	115	broad.mit.edu	37	chr16	4016798	4016798	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttggtgcggtgaagatccgCttccacgtctccgtggtagt	13	11	1	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr16:4016798C>T	uc002cvx.2	-	11	3579	c.3040G>A	c.(3040-3042)GCG>ACG	p.A1014T		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	1014	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						TGAAGATCCGCTTCCACGTCT	0.567													T	4016798	T	T	4016798	3	4	134	1	0	0	0	0	1	0	0	0	301	797	28	3	1025	3	ADCY9	16	4016798	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08		4016798	86337955	31	9274											
CRYM	1428	broad.mit.edu	37	chr16	21273454	21273454	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agctcatcatccagttctctCcagtcaggtctgctggctcc	8	15	5	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr16:21273454C>A	uc002dik.2	-	6	784	c.699G>T	c.(697-699)TGG>TGT	p.W233C	CRYM_uc010bwq.1_RNA|CRYM_uc002dil.2_Missense_Mutation_p.W191C|CRYM_uc002dim.2_Missense_Mutation_p.W233C	NM_001888	NP_001879	Q14894	CRYM_HUMAN	crystallin, mu isoform 1	233					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity				0				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	CCAGTTCTCTCCAGTCAGGTC	0.532													A	21273454	A	A	21273454	3	1	134	1	0	0	0	0	1	0	0	0	3921	856	30	5	257	5	CRYM	16	21273454	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	17256656	21273454	69081299	32	9275											
PRSS36	146547	broad.mit.edu	37	chr16	31151619	31151619	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcccaggcccctgtacctcaCacctgttctcctgcccctct	6	21	3	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr16:31151619C>A	uc002ebd.2	-	14	2344	c.2285G>T	c.(2284-2286)TGT>TTT	p.C762F	PRSS36_uc010vff.1_Missense_Mutation_p.C537F|PRSS36_uc010vfg.1_Missense_Mutation_p.C757F|PRSS36_uc010vfh.1_Intron	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	762	Peptidase S1 3.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						CTGTACCTCACACCTGTTCTC	0.527													A	31151619	A	A	31151619	3	1	134	1	0	0	0	0	1	0	0	0	12625	478	17	5	290	5	PRSS36	16	31151619	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	9878165	31151619	59203134	33	9276											
NTN1	9423	broad.mit.edu	37	chr17	9066306	9066306	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcaagcccatcacccaccggAaggcctgcaaaggtgggcta	12	14	1	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr17:9066306A>T	uc002glw.3	+	3	1302	c.1195A>T	c.(1195-1197)AAG>TAG	p.K399*		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	399	Laminin EGF-like 2.				apoptosis|axon guidance		protein binding				0						CACCCACCGGAAGGCCTGCAA	0.637													T	9066306	T	T	9066306	4	4	134	1	0	0	0	0	0	1	0	0	10700	247	9	5	1201	5	NTN1	17	9066306	Nonsense_Mutation	SNP	A	TCGA-14-0862-01B-01D-1845-08		9066306	72128904	34	9277											
HNF1B	6928	broad.mit.edu	37	chr17	36059152	36059152	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaccaccattgcagatggaAaccgggaggtgtgggaatac	14	8	0	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr17:36059152A>G	uc002hok.3	-	8	1804	c.1583T>C	c.(1582-1584)TTT>TCT	p.F528S	HNF1B_uc010wdi.1_Missense_Mutation_p.F502S	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	528					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TGCAGATGGAAACCGGGAGGT	0.517									Hereditary_Prostate_Cancer				G	36059152	G	G	36059152	3	3	134	1	0	0	0	0	1	0	0	0	7252	14	1	4	98	4	HNF1B	17	36059152	Missense_Mutation	SNP	A	TCGA-14-0862-01B-01D-1845-08	26992846	36059152	45136058	35	9278											
TMC8	147138	broad.mit.edu	37	chr17	76128876	76128876	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcctcaacagccctccaGtgccctggtagccgccagtc	8	19	1	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr17:76128876G>A	uc002jup.2	+	5	838	c.456G>A	c.(454-456)CAG>CAA	p.Q152Q	TMC6_uc002jul.1_5'Flank|TMC8_uc002juq.2_Translation_Start_Site|TMC8_uc010wtr.1_5'Flank	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	152	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			CAGCCCTCCAGTGCCCTGGTA	0.592									Epidermodysplasia_Verruciformis_Familial_Clustering_of				A	76128876	A	A	76128876	2	1	134	1	0	0	0	0	0	0	0	1	15988	1020	36	3		3	TMC8	17	76128876	Silent	SNP	G	TCGA-14-0862-01B-01D-1845-08	40069724	76128876	5066334	36	9279											
DSC1	1823	broad.mit.edu	37	chr18	28712602	28712602	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggctatgtcttctggaaaacAtttcttgactgttctcttag	8	8	4	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr18:28712602A>T	uc002kwn.2	-	14	2429	c.2167T>A	c.(2167-2169)TGT>AGT	p.C723S	DSC1_uc002kwm.2_Missense_Mutation_p.C723S	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	723	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TCTGGAAAACATTTCTTGACT	0.328													T	28712602	T	T	28712602	3	4	134	1	0	0	0	0	1	0	0	0	4765	217	8	5	569	5	DSC1	18	28712602	Missense_Mutation	SNP	A	TCGA-14-0862-01B-01D-1845-08		28712602	49364646	37	9280											
REXO1	57455	broad.mit.edu	37	chr19	1827919	1827924	+	In_Frame_Del	DEL	TCTGAG	-	-													ggaccgtggcggcctcatctTctgagtctgagaaccttgca							TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr19:1827919_1827924delTCTGAG	uc002lua.3	-	2	959_964	c.864_869delCTCAGA	c.(862-870)GACTCAGAA>GAA	p.DS288del	REXO1_uc010dsr.1_In_Frame_Del_p.DS242del	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	288_289						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCTCATCTTCTGAGTCTGAGAACC	0.67													-	1827924	-	-	1827919	7	5	134	1	0	1	0	1	0	0	0	0	13241	1783	62	0	2856	0	REXO1	19	1827919	In_Frame_Del	DEL	TCTGAG	TCGA-14-0862-01B-01D-1845-08		1827919	57301064	38	9281											
GNA11	2767	broad.mit.edu	37	chr19	3113330	3113330	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgcccgccctcgcaggcCaatgcgctcctgatccggga	11	19	0	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr19:3113330C>T	uc002lxd.2	+	3	566	c.324C>T	c.(322-324)GCC>GCT	p.A108A		NM_002067	NP_002058	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein),	108					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			eye(70)|skin(16)	86		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		CCTCGCAGGCCAATGCGCTCC	0.662			Mis		uveal melanoma								T	3113330	T	T	3113330	2	4	134	1	0	0	0	0	0	0	0	1	6499	581	21	3		3	GNA11	19	3113330	Silent	SNP	C	TCGA-14-0862-01B-01D-1845-08	1285411	3113330	56015653	39	9282											
MCOLN1	57192	broad.mit.edu	37	chr19	7593590	7593590	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggcttcctgctgcagaacGtgaggcttctgcgtcatgtg	14	10	2	2			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr19:7593590G>A	uc002mgo.2	+	8	1109	c.984_splice	c.e8+1	p.N328_splice	MCOLN1_uc002mgp.2_Splice_Site_p.N293_splice	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1						calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						GCTGCAGAACGTGAGGCTTCT	0.637													A	7593590	A	A	7593590	5	1	134	1	0	0	0	0	0	0	1	0	9395	1159	40	1	1015	1	MCOLN1	19	7593590	Splice_Site	SNP	G	TCGA-14-0862-01B-01D-1845-08	4480260	7593590	51535393	40	9283											
MUC16	94025	broad.mit.edu	37	chr19	9020077	9020077	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gctcccagtacagccgctctCtgttgagtccagggcttttg	11	13	1	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr19:9020077C>T	uc002mkp.2	-	21	37622	c.37418G>A	c.(37417-37419)AGA>AAA	p.R12473K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12475	Extracellular (Potential).|SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGCCGCTCTCTGTTGAGTCC	0.562													T	9020077	T	T	9020077	3	4	134	1	0	0	0	0	1	0	0	0	9973	913	32	3	6361	3	MUC16	19	9020077	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	1426487	9020077	50108906	41	9284											
OR7G2	390882	broad.mit.edu	37	chr19	9213273	9213273	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggtgatctgagtgtaagacAaaatgattccagacagagga	12	5	1	6			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr19:9213273A>G	uc010xkk.1	-	1	710	c.710T>C	c.(709-711)TTG>TCG	p.L237S		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGTGTAAGACAAAATGATTCC	0.448													G	9213273	G	G	9213273	3	3	134	1	0	0	0	0	1	0	0	0	11223	131	5	4	329	4	OR7G2	19	9213273	Missense_Mutation	SNP	A	TCGA-14-0862-01B-01D-1845-08	193196	9213273	49915710	42	9285											
AKAP8	10270	broad.mit.edu	37	chr19	15484623	15484623	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cggtcctgtatgccctccccAccgccgccgctcccgcccct	8	24	0	0	rs117407939		TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr19:15484623A>G	uc002nav.2	-	4	406	c.345T>C	c.(343-345)GGT>GGC	p.G115G	AKAP8_uc010dzy.2_5'Flank|AKAP8_uc010dzz.1_RNA|AKAP8_uc010xog.1_Intron	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	115	Poly-Gly.				signal transduction	nuclear matrix				ovary(1)|breast(1)	2						TGCCCTCCCCACCGCCGCCGC	0.632													G	15484623	G	G	15484623	2	3	134	1	0	0	0	0	0	0	0	1	457	146	6	4		4	AKAP8	19	15484623	Silent	SNP	A	TCGA-14-0862-01B-01D-1845-08	6271350	15484623	43644360	43	9286											
ZNF99	7652	broad.mit.edu	37	chr19	22941396	22941396	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tatcttatgttttctaagggCtgagaaacgcttaaaagctt	8	6	2	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr19:22941396C>A	uc010xrh.1	-	5	1042	c.1042G>T	c.(1042-1044)GCC>TCC	p.A348S		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTCTAAGGGCTGAGAAACGC	0.363													A	22941396	A	A	22941396	3	1	134	1	0	0	0	0	1	0	0	0	18201	797	28	5	2082	5	ZNF99	19	22941396	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	7456773	22941396	36187587	44	9287											
FCGBP	8857	broad.mit.edu	37	chr19	40363235	40363235	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atgtttcggccctcggcggtCacccgcacgcggcccacagc	12	18	1	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr19:40363235C>T	uc002omp.3	-	32	14843	c.14835G>A	c.(14833-14835)GTG>GTA	p.V4945V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4945	VWFD 12.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCTCGGCGGTCACCCGCACGC	0.657													T	40363235	T	T	40363235	2	4	134	1	0	0	0	0	0	0	0	1	5778	813	29	3		3	FCGBP	19	40363235	Silent	SNP	C	TCGA-14-0862-01B-01D-1845-08	17421839	40363235	18765748	45	9288											
KCNG1	3755	broad.mit.edu	37	chr20	49626630	49626630	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcgcgtcagcgggaactcGtccagcgtggtccagggcag	17	12	1	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr20:49626630G>A	uc002xwa.3	-	2	541	c.246C>T	c.(244-246)GAC>GAT	p.D82D	KCNG1_uc002xwb.2_Silent_p.D82D	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	82	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						GCGGGAACTCGTCCAGCGTGG	0.632													A	49626630	A	A	49626630	2	1	134	1	0	0	0	0	0	0	0	1	8027	1136	40	1		1	KCNG1	20	49626630	Silent	SNP	G	TCGA-14-0862-01B-01D-1845-08		49626630	13398890	46	9289											
LZTR1	8216	broad.mit.edu	37	chr22	21349215	21349217	+	In_Frame_Del	DEL	GAA	-	-													ttcaaccaggtgatcatgatGaaggagttcgagcgcctctc							TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr22:21349215_21349217delGAA	uc002zto.2	+	16	1945_1947	c.1842_1844delGAA	c.(1840-1845)ATGAAG>ATG	p.K615del	LZTR1_uc002ztn.2_In_Frame_Del_p.K574del|LZTR1_uc011ahy.1_In_Frame_Del_p.K596del|LZTR1_uc002ztp.2_5'Flank	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	615					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGATCATGATGAAGGAGTTCGAG	0.601													-	21349217	-	-	21349215	7	5	134	1	0	1	0	1	0	0	0	0	9137	1290	45	0	1904	0	LZTR1	22	21349215	In_Frame_Del	DEL	GAA	TCGA-14-0862-01B-01D-1845-08		21349215	29955351	47	9290											
MN1	4330	broad.mit.edu	37	chr22	28193444	28193444	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgtccgacttggccccgcCgtccagggacccaatgaggt	12	15	0	1			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chr22:28193444C>T	uc003adj.2	-	1	4043	c.3088G>A	c.(3088-3090)GGC>AGC	p.G1030S		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1030							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						TTGGCCCCGCCGTCCAGGGAC	0.657			T	ETV6	AML|meningioma								T	28193444	T	T	28193444	3	4	134	1	0	0	0	0	1	0	0	0	9673	652	23	2	882	2	MN1	22	28193444	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	6844229	28193444	23111122	48	9291											
MID1	4281	broad.mit.edu	37	chrX	10535512	10535512	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgaagcagaggctgtgtgCgcagggcagtagaagagggt	19	5	0	4			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chrX:10535512C>T	uc004cte.3	-	2	267	c.76G>A	c.(76-78)GCA>ACA	p.A26T	MID1_uc004ctd.3_5'Flank|MID1_uc004ctg.3_Missense_Mutation_p.A26T|MID1_uc004cth.3_Missense_Mutation_p.A26T|MID1_uc004ctk.3_Missense_Mutation_p.A26T|MID1_uc004cti.3_Missense_Mutation_p.A26T|MID1_uc004ctj.3_Missense_Mutation_p.A26T|MID1_uc011mie.1_RNA|MID1_uc004ctm.1_Missense_Mutation_p.A26T|MID1_uc004ctn.1_Missense_Mutation_p.A26T|MID1_uc004cto.1_Missense_Mutation_p.A26T|MID1_uc010ndw.1_5'Flank|MID1_uc004cts.1_5'Flank|MID1_uc004ctt.2_Missense_Mutation_p.A26T|MID1_uc004ctu.2_Missense_Mutation_p.A26T|MID1_uc004ctv.2_Missense_Mutation_p.A26T|MID1_uc004ctw.2_Missense_Mutation_p.A26T|MID1_uc010ndy.1_Missense_Mutation_p.A26T|uc010ndz.1_5'Flank|MID1_uc004cty.2_Missense_Mutation_p.A26T|MID1_uc004ctz.1_5'Flank|MID1_uc004cua.1_RNA|MID1_uc004cub.1_Missense_Mutation_p.A26T|MID1_uc010nea.1_5'Flank|MID1_uc004cuc.1_Missense_Mutation_p.A26T|MID1_uc004cud.1_Missense_Mutation_p.A26T|MID1_uc004cue.1_Missense_Mutation_p.A26T|MID1_uc004cuf.1_Missense_Mutation_p.A26T|MID1_uc004cug.1_Missense_Mutation_p.A26T	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	26	RING-type.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						AGGCTGTGTGCGCAGGGCAGT	0.557													T	10535512	T	T	10535512	3	4	134	1	0	0	0	0	1	0	0	0	9576	768	27	1	1963	1	MID1	23	10535512	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08		10535512	144735048	49	9292											
DCAF12L2	340578	broad.mit.edu	37	chrX	125299277	125299277	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacggtgccgtcgcgggagcCgctcacagctacggtgtcac	14	15	2	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chrX:125299277C>T	uc004euk.1	-	1	658	c.631G>A	c.(631-633)GGC>AGC	p.G211S		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	211	WD 2.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						TCGCGGGAGCCGCTCACAGCT	0.647													T	125299277	T	T	125299277	3	4	134	1	0	0	0	0	1	0	0	0	4265	652	23	2	764	2	DCAF12L2	23	125299277	Missense_Mutation	SNP	C	TCGA-14-0862-01B-01D-1845-08	114763765	125299277	29971283	50	9293											
FRMD7	90167	broad.mit.edu	37	chrX	131212955	131212955	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtgcactccattcacattttGgtagtagccaccaccatatg	7	12	1	0			TCGA-14-0862-01B-01D-1845-08	TCGA-14-0862-10C-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0b7d451-8190-45a4-8242-bf698f05243d	d15b6e3c-742f-48d9-bd31-63f930b56060	g.chrX:131212955G>C	uc004ewn.2	-	12	1268	c.1090C>G	c.(1090-1092)CAA>GAA	p.Q364E	FRMD7_uc011muy.1_Missense_Mutation_p.Q349E	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	364					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TTCACATTTTGGTAGTAGCCA	0.294													C	131212955	C	C	131212955	3	2	134	1	0	0	0	0	1	0	0	0	6055	1357	47	5	1058	5	FRMD7	23	131212955	Missense_Mutation	SNP	G	TCGA-14-0862-01B-01D-1845-08	5913678	131212955	24057605	51	9294											
FUCA1	2517	broad.mit.edu	37	chr1	24189688	24189688	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaatgctgtgttttgaagcCatttttcttatcaagtagat	7	5	2	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr1:24189688C>T	uc001bie.2	-	3	643	c.598G>A	c.(598-600)GGC>AGC	p.G200S	FUCA1_uc009vqt.1_RNA|FUCA1_uc010oed.1_RNA	NM_000147	NP_000138	P04066	FUCO_HUMAN	fucosidase, alpha-L-1, tissue precursor	200					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		GTTTTGAAGCCATTTTTCTTA	0.388													T	24189688	T	T	24189688	3	4	135	1	0	0	0	0	1	0	0	0	6094	594	21	3	826	3	FUCA1	1	24189688	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08		24189688	225060933	1	9295			1	29		2	2	40	C		8.440455e-05
FUCA1	2517	broad.mit.edu	37	chr1	24189727	24189727	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atagagtggatggaaccactCtaagagtgagtggtatagtc	13	5	1	3			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr1:24189727C>T	uc001bie.2	-	3	604	c.559G>A	c.(559-561)GAG>AAG	p.E187K	FUCA1_uc009vqt.1_RNA|FUCA1_uc010oed.1_RNA	NM_000147	NP_000138	P04066	FUCO_HUMAN	fucosidase, alpha-L-1, tissue precursor	187					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		TGGAACCACTCTAAGAGTGAG	0.358													T	24189727	T	T	24189727	3	4	135	1	0	0	0	0	1	0	0	0	6094	922	32	3	865	3	FUCA1	1	24189727	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	39	24189727	225060894	2	9296			1	29		2	2	40	C		8.440455e-05
LRRC41	10489	broad.mit.edu	37	chr1	46745257	46745257	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aaattgggctgggcgcttctCaaacagacggcagaaggaga	14	8	1	3			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr1:46745257C>G	uc001cpn.2	-	8	2094	c.2050G>C	c.(2050-2052)GAG>CAG	p.E684Q	LRRC41_uc010omb.1_Missense_Mutation_p.E684Q	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	684										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					GGGCGCTTCTCAAACAGACGG	0.552													G	46745257	G	G	46745257	3	3	135	1	0	0	0	0	1	0	0	0	8999	835	29	5	400	5	LRRC41	1	46745257	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	22555530	46745257	202505364	3	9297											
IFI16	3428	broad.mit.edu	37	chr1	158986412	158986412	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cctccctctcctgcaggagcCggcatgtccacagccatggg	11	17	1	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr1:158986412C>G	uc001ftf.1	+	5	1078	c.471C>G	c.(469-471)GCC>GCG	p.A157A	IFI16_uc001ftg.2_Silent_p.A157A|IFI16_uc010pis.1_Intron	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	157					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					CTGCAGGAGCCGGCATGTCCA	0.522													G	158986412	G	G	158986412	2	3	135	1	0	0	0	0	0	0	0	1	7511	639	23	5		5	IFI16	1	158986412	Silent	SNP	C	TCGA-14-0871-01A-01W-0424-08	112241155	158986412	90264209	4	9298											
NR5A2	2494	broad.mit.edu	37	chr1	200017711	200017711	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gggctattcatatatggataGttaccagacgagctctccag	10	9	2	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr1:200017711G>C	uc001gvb.2	+	5	1081	c.875G>C	c.(874-876)AGT>ACT	p.S292T	NR5A2_uc001gvc.2_Missense_Mutation_p.S246T|NR5A2_uc009wzh.2_Missense_Mutation_p.S252T|NR5A2_uc010pph.1_Missense_Mutation_p.S220T	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	292					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					TATATGGATAGTTACCAGACG	0.488													C	200017711	C	C	200017711	3	2	135	1	0	0	0	0	1	0	0	0	10636	1029	36	5	893	5	NR5A2	1	200017711	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	41031299	200017711	49232910	5	9299											
OR2T3	343173	broad.mit.edu	37	chr1	248637231	248637231	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgccctgctgaagctctccTgctctgacgtctccctctat	7	17	4	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr1:248637231T>C	uc001iel.1	+	1	580	c.580T>C	c.(580-582)TGC>CGC	p.C194R		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAAGCTCTCCTGCTCTGACGT	0.517													C	248637231	C	C	248637231	3	2	135	1	0	0	0	0	1	0	0	0	11023	1580	55	4	582	4	OR2T3	1	248637231	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08	48619520	248637231	613390	6	9300											
APOB	338	broad.mit.edu	37	chr2	21247830	21247830	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggggatcccctgcagagtgCgggcacccatcagaagcagc	15	13	1	2	rs148190577	byFrequency	TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr2:21247830C>T	uc002red.2	-	16	2539	c.2411G>A	c.(2410-2412)CGC>CAC	p.R804H		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	804				LQLLGKLLLMGARTLQGI -> SSSWKAASHGCPHSAGD (in Ref. 12; AAA51759).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGCAGAGTGCGGGCACCCAT	0.587													T	21247830	T	T	21247830	3	4	135	1	0	0	0	0	1	0	0	0	785	768	27	1	11336	1	APOB	2	21247830	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08		21247830	221951543	7	9301											
NRXN1	9378	broad.mit.edu	37	chr2	50765702	50765702	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcccccccaggtacaactcaTcatccaggtccagaatctca	6	17	3	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr2:50765702T>A	uc010fbq.2	-	10	3429	c.1952A>T	c.(1951-1953)GAT>GTT	p.D651V	NRXN1_uc002rxb.3_Missense_Mutation_p.D283V|NRXN1_uc002rxe.3_Missense_Mutation_p.D611V|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GTACAACTCATCATCCAGGTC	0.527													A	50765702	A	A	50765702	3	1	135	1	0	0	0	0	1	0	0	0	10665	1435	50	5	3010	5	NRXN1	2	50765702	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08	29517872	50765702	192433671	8	9302											
ARHGAP25	9938	broad.mit.edu	37	chr2	69046427	69046427	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actgaagacctccgaatttcTaggacagacagcttcagtag	9	10	2	3			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr2:69046427T>C	uc002seu.2	+	9	1537	c.1173T>C	c.(1171-1173)TCT>TCC	p.S391S	ARHGAP25_uc010fdg.2_Silent_p.S392S|ARHGAP25_uc010yql.1_Silent_p.S352S|ARHGAP25_uc002sev.2_Silent_p.S385S|ARHGAP25_uc002sew.2_Silent_p.S384S|ARHGAP25_uc002sex.2_Silent_p.S385S|ARHGAP25_uc002sey.2_Silent_p.S118S	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	391					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TCCGAATTTCTAGGACAGACA	0.532													C	69046427	C	C	69046427	2	2	135	1	0	0	0	0	0	0	0	1	874	1509	53	4		4	ARHGAP25	2	69046427	Silent	SNP	T	TCGA-14-0871-01A-01W-0424-08	18280725	69046427	174152946	9	9303											
LMAN2L	81562	broad.mit.edu	37	chr2	97400183	97400183	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttgtgtaccagattgccaaGccatccccatgcagattctt	7	12	1	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr2:97400183G>C	uc002swu.2	-	3	423	c.387C>G	c.(385-387)GGC>GGG	p.G129G	LMAN2L_uc002swv.2_Silent_p.G129G|LMAN2L_uc010yut.1_Missense_Mutation_p.A12G|LMAN2L_uc010yuu.1_5'UTR|LMAN2L_uc010yuv.1_5'UTR|LMAN2L_uc010yuw.1_Missense_Mutation_p.A12G|LMAN2L_uc002sww.2_5'UTR|LMAN2L_uc010yux.1_Missense_Mutation_p.A12G	NM_030805	NP_110432	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like isoform 2	129	L-type lectin-like.|Lumenal (Potential).				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding				0						AGATTGCCAAGCCATCCCCAT	0.473													C	97400183	C	C	97400183	2	2	135	1	0	0	0	0	0	0	0	1	8839	958	34	5		5	LMAN2L	2	97400183	Silent	SNP	G	TCGA-14-0871-01A-01W-0424-08	28353756	97400183	145799190	10	9304											
MFSD9	84804	broad.mit.edu	37	chr2	103340253	103340253	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ccaccgaccacggggcccaaGatgaagcccacaccggaggc	12	17	0	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr2:103340253G>C	uc002tcb.2	-	5	611	c.543C>G	c.(541-543)ATC>ATG	p.I181M	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	181	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						CGGGGCCCAAGATGAAGCCCA	0.502													C	103340253	C	C	103340253	3	2	135	1	0	0	0	0	1	0	0	0	9539	932	33	5	889	5	MFSD9	2	103340253	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	5940070	103340253	139859120	11	9305											
FIGN	55137	broad.mit.edu	37	chr2	164466661	164466661	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gataattttctctgcttctcCtaaccacttggcgactagtc	6	12	2	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr2:164466661C>T	uc002uck.1	-	3	1992	c.1681G>A	c.(1681-1683)GGA>AGA	p.G561R		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	561						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						TCTGCTTCTCCTAACCACTTG	0.493													T	164466661	T	T	164466661	3	4	135	1	0	0	0	0	1	0	0	0	5891	690	24	3	602	3	FIGN	2	164466661	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	61126408	164466661	78732712	12	9306											
CPO	130749	broad.mit.edu	37	chr2	207827161	207827161	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcctctagaaactgccaAgatcaaacattctgtgggac	10	10	3	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr2:207827161A>T	uc002vby.2	+	7	646	c.600A>T	c.(598-600)CAA>CAT	p.Q200H		NM_173077	NP_775100	Q8IVL8	CBPO_HUMAN	carboxypeptidase O precursor	200					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		GAAACTGCCAAGATCAAACAT	0.448													T	207827161	T	T	207827161	3	4	135	1	0	0	0	0	1	0	0	0	3820	69	3	5	626	5	CPO	2	207827161	Missense_Mutation	SNP	A	TCGA-14-0871-01A-01W-0424-08	43360500	207827161	35372212	13	9307											
SPHKAP	80309	broad.mit.edu	37	chr2	228881144	228881144	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggatttgacaagcgctcaCggctgtgtctccacctctca	9	13	3	1	rs150119101		TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr2:228881144C>T	uc002vpq.2	-	7	4473	c.4426G>A	c.(4426-4428)GTG>ATG	p.V1476M	SPHKAP_uc002vpp.2_Missense_Mutation_p.V1476M|SPHKAP_uc010zlx.1_Missense_Mutation_p.V1476M	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1476						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAAGCGCTCACGGCTGTGTCT	0.463													T	228881144	T	T	228881144	3	4	135	1	0	0	0	0	1	0	0	0	15047	536	19	1	700	1	SPHKAP	2	228881144	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	21053983	228881144	14318229	14	9308											
COL7A1	1294	broad.mit.edu	37	chr3	48612126	48612126	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcaccctgtctcctttgggaCcttggtcaccattgctgccc	8	16	3	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr3:48612126C>G	uc003ctz.2	-	77	6378	c.6377G>C	c.(6376-6378)GGT>GCT	p.G2126A		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2126	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCCTTTGGGACCTTGGTCACC	0.607													G	48612126	G	G	48612126	3	3	135	1	0	0	0	0	1	0	0	0	3704	507	18	5	2625	5	COL7A1	3	48612126	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08		48612126	149410304	15	9309											
C3orf38	285237	broad.mit.edu	37	chr3	88205314	88205314	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggggaccacagcacttctgGcatgatgtgaagcttaggtt	13	8	1	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr3:88205314G>A	uc003dqw.2	+	4	830	c.519G>A	c.(517-519)TGG>TGA	p.W173*		NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	173					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		AGCACTTCTGGCATGATGTGA	0.418													A	88205314	A	A	88205314	4	1	135	1	0	0	0	0	0	1	0	0	2228	1212	42	3	529	3	C3orf38	3	88205314	Nonsense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	39593188	88205314	109817116	16	9310											
DRD3	1814	broad.mit.edu	37	chr3	113847759	113847759	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagcagacaatgaaggccCctaagttgccaaataagaga	10	10	0	3			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr3:113847759C>T	uc003ebd.2	-	8	1430	c.1007G>A	c.(1006-1008)GGG>GAG	p.G336E	DRD3_uc010hqn.1_Missense_Mutation_p.G336E|DRD3_uc003ebb.1_Missense_Mutation_p.G303E|DRD3_uc003ebc.1_Missense_Mutation_p.G336E	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	336	Helical; Name=6.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	AATGAAGGCCCCTAAGTTGCC	0.428													T	113847759	T	T	113847759	3	4	135	1	0	0	0	0	1	0	0	0	4758	637	22	3	199	3	DRD3	3	113847759	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	25642445	113847759	84174671	17	9311											
PPM1L	151742	broad.mit.edu	37	chr3	160786689	160786689	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttatccgctgaaaaatctcaAcgtggtcatcccagacccag	7	13	2	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr3:160786689A>G	uc003fdr.2	+	4	928	c.827A>G	c.(826-828)AAC>AGC	p.N276S	PPM1L_uc003fds.2_Missense_Mutation_p.N97S|PPM1L_uc003fdt.2_Missense_Mutation_p.N149S|PPM1L_uc010hwf.2_RNA	NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	276	Cytoplasmic (Potential).|PP2C-like.				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			AAAAATCTCAACGTGGTCATC	0.522													G	160786689	G	G	160786689	3	3	135	1	0	0	0	0	1	0	0	0	12344	43	2	4	841	4	PPM1L	3	160786689	Missense_Mutation	SNP	A	TCGA-14-0871-01A-01W-0424-08	46938930	160786689	37235741	18	9312											
PCYT1A	5130	broad.mit.edu	37	chr3	195969479	195969479	+	Nonsense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatcactgccagcagatgaAtaaggaatatcatcatgggc	9	9	4	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr3:195969479A>C	uc003fwg.2	-	7	692	c.519T>G	c.(517-519)TAT>TAG	p.Y173*	PCYT1A_uc003fwh.2_Nonsense_Mutation_p.Y173*	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	173	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	CAGCAGATGAATAAGGAATAT	0.428													C	195969479	C	C	195969479	4	2	135	1	0	0	0	0	0	1	0	0	11610	108	4	5	600	5	PCYT1A	3	195969479	Nonsense_Mutation	SNP	A	TCGA-14-0871-01A-01W-0424-08	35182790	195969479	2052951	19	9313											
CYP2U1	113612	broad.mit.edu	37	chr4	108866315	108866315	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctccatcatcagcaatgCcgtctctaacatcatttgct	4	13	5	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr4:108866315C>T	uc003hyp.2	+	2	763	c.680C>T	c.(679-681)GCC>GTC	p.A227V	CYP2U1_uc011cfi.1_Missense_Mutation_p.A18V	NM_183075	NP_898898	Q7Z449	CP2U1_HUMAN	cytochrome P450, family 2, subfamily U,	227					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000128)		ATCAGCAATGCCGTCTCTAAC	0.438													T	108866315	T	T	108866315	3	4	135	1	0	0	0	0	1	0	0	0	4175	739	26	3	686	3	CYP2U1	4	108866315	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08		108866315	82287961	20	9314											
ANK2	287	broad.mit.edu	37	chr4	114279919	114279919	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggacaggacatggcaagcaTcgcaccagataatagaagca	12	9	0	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr4:114279919T>C	uc003ibe.3	+	38	10245	c.10145T>C	c.(10144-10146)ATC>ACC	p.I3382T	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.I684T|ANK2_uc011cgb.1_Missense_Mutation_p.I3397T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3349					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATGGCAAGCATCGCACCAGAT	0.463													C	114279919	C	C	114279919	3	2	135	1	0	0	0	0	1	0	0	0	621	1435	50	4	10360	4	ANK2	4	114279919	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08	5413604	114279919	76874357	21	9315											
MLF1IP	79682	broad.mit.edu	37	chr4	185631267	185631267	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaaattcaggcaaaacaatAttcaactccttgatgtcact	4	10	4	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr4:185631267A>G	uc003iwq.2	-	8	826	c.756T>C	c.(754-756)AAT>AAC	p.N252N	MLF1IP_uc003iwp.2_RNA|MLF1IP_uc003iwr.1_Silent_p.N252N	NM_024629	NP_078905	Q71F23	CENPU_HUMAN	MLF1 interacting protein	252					CenH3-containing nucleosome assembly at centromere|interspecies interaction between organisms|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|condensed chromosome kinetochore|cytosol|nucleoplasm					0		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Hepatocellular(41;0.000519)|Colorectal(36;0.00172)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.0299)|all_hematologic(60;0.0592)|Medulloblastoma(177;0.146)		all cancers(43;7.83e-28)|Epithelial(43;2.56e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-11)|Colorectal(24;3.27e-06)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.16e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000252)|COAD - Colon adenocarcinoma(29;0.000512)|LUSC - Lung squamous cell carcinoma(40;0.01)|READ - Rectum adenocarcinoma(43;0.0419)		GCAAAACAATATTCAACTCCT	0.303													G	185631267	G	G	185631267	2	3	135	1	0	0	0	0	0	0	0	1	9615	446	16	4		4	MLF1IP	4	185631267	Silent	SNP	A	TCGA-14-0871-01A-01W-0424-08	71351348	185631267	5523009	22	9316											
MTRR	4552	broad.mit.edu	37	chr5	7875377	7875377	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgggttctctaggtctcgGtgattcagaatacacctact	9	9	3	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr5:7875377G>A	uc003jed.2	+	4	401	c.371G>A	c.(370-372)GGT>GAT	p.G124D	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.G97D|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	124	FMN (By similarity).|Flavodoxin-like.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CTAGGTCTCGGTGATTCAGAA	0.348													A	7875377	A	A	7875377	3	1	135	1	0	0	0	0	1	0	0	0	9961	1261	44	3	385	3	MTRR	5	7875377	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08		7875377	173039883	23	9317											
MARCH6	10299	broad.mit.edu	37	chr5	10423856	10423857	+	Frame_Shift_Ins	INS	-	T	T													aattccctaggactgggcacINSttggagtcctgcatgccaaa							TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr5:10423856_10423857insT	uc003jet.1	+	23	2476_2477	c.2293_2294insT	c.(2293-2295)CTTfs	p.L765fs	MARCH6_uc011cmu.1_Frame_Shift_Ins_p.L717fs|MARCH6_uc003jeu.1_Frame_Shift_Ins_p.L463fs|MARCH6_uc011cmv.1_Frame_Shift_Ins_p.L660fs	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	765	Helical; (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						GGACTGGGCACTTGGAGTCCTG	0.361													T	10423857	T	T	10423856	7	5	135	1	0	1	1	0	0	0	0	0	9305	565	20	0	2383	0	MARCH6	5	10423856	Frame_Shift_Ins	INS	-	TCGA-14-0871-01A-01W-0424-08	2548479	10423856	170491404	24	9318											
RAB24	53917	broad.mit.edu	37	chr5	176729179	176729179	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caaagagctgagctttgataTctgtaaagagaagtgactaa	10	5	1	5			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr5:176729179T>C	uc003mfv.2	-	7	803	c.434A>G	c.(433-435)AAT>AGT	p.N145S	RAB24_uc003mfu.2_Missense_Mutation_p.N116S|RAB24_uc003mfw.2_Missense_Mutation_p.N145S|PRELID1_uc003mfx.2_5'Flank|PRELID1_uc003mfy.2_5'Flank	NM_130781	NP_570137	Q969Q5	RAB24_HUMAN	RAB24 gene product	145					autophagy|protein transport|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|protein binding				0	all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTTTGATATCTGTAAAGAG	0.502													C	176729179	C	C	176729179	3	2	135	1	0	0	0	0	1	0	0	0	12911	1449	50	4	189	4	RAB24	5	176729179	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08	166305323	176729179	4186081	25	9319											
HUS1B	135458	broad.mit.edu	37	chr6	656375	656375	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctccgtctctatactcagGgtcatcctgccactgaggtt	8	14	3	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr6:656375G>A	uc003mtg.2	-	1	590	c.570C>T	c.(568-570)ACC>ACT	p.T190T	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	190											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		CTATACTCAGGGTCATCCTGC	0.562													A	656375	A	A	656375	2	1	135	1	0	0	0	0	0	0	0	1	7460	1219	43	3		3	HUS1B	6	656375	Silent	SNP	G	TCGA-14-0871-01A-01W-0424-08		656375	170458692	26	9320											
TTBK1	84630	broad.mit.edu	37	chr6	43250498	43250498	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgcccccatttgaggtgaatGgcctcccacgagctgtgcct	11	15	0	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr6:43250498G>T	uc003ouq.1	+	14	2299	c.2020G>T	c.(2020-2022)GGC>TGC	p.G674C		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	674						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity	p.G674G(1)		lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TGAGGTGAATGGCCTCCCACG	0.612													T	43250498	T	T	43250498	3	4	135	1	0	0	0	0	1	0	0	0	16673	1348	47	5	2070	5	TTBK1	6	43250498	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	42594123	43250498	127864569	27	9321											
SYNE1	23345	broad.mit.edu	37	chr6	152779932	152779932	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggcactcgattgtgcctcaCgctcaagaactgtgataatt	10	10	2	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr6:152779932C>G	uc010kiw.2	-	22	3130	c.2528G>C	c.(2527-2529)CGT>CCT	p.R843P	SYNE1_uc003qot.3_Missense_Mutation_p.R850P|SYNE1_uc003qou.3_Missense_Mutation_p.R843P|SYNE1_uc010kjb.1_Missense_Mutation_p.R826P|SYNE1_uc003qow.2_Missense_Mutation_p.R138P|SYNE1_uc003qox.1_Missense_Mutation_p.R359P|SYNE1_uc003qoz.2_Missense_Mutation_p.R275P|SYNE1_uc003qoy.2_Missense_Mutation_p.R410P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	843	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTGTGCCTCACGCTCAAGAAC	0.403										HNSCC(10;0.0054)			G	152779932	G	G	152779932	3	3	135	1	0	0	0	0	1	0	0	0	15442	536	19	5	24438	5	SYNE1	6	152779932	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	109529434	152779932	18335135	28	9322											
GIMAP2	26157	broad.mit.edu	37	chr7	150390248	150390248	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctgtggctttgcatactgCacagcatgtgcaatttgttt	9	8	1	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr7:150390248C>T	uc003who.2	+	3	962	c.874C>T	c.(874-876)CAC>TAC	p.H292Y	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	292						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTGCATACTGCACAGCATGTG	0.328													T	150390248	T	T	150390248	3	4	135	1	0	0	0	0	1	0	0	0	6380	710	25	3	880	3	GIMAP2	7	150390248	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08		150390248	8748415	29	9323											
GIMAP5	55340	broad.mit.edu	37	chr7	150440111	150440111	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tctattgttgtgcagcatacTttttttcattatttttctgt	5	6	3	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr7:150440111T>A	uc003whr.1	+	3	1236	c.884T>A	c.(883-885)CTT>CAT	p.L295H	GIMAP5_uc010lpu.2_Missense_Mutation_p.L153H	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	295	Helical; Anchor for type IV membrane protein; (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCAGCATACTTTTTTTCATT	0.368													A	150440111	A	A	150440111	3	1	135	1	0	0	0	0	1	0	0	0	6382	1609	56	5	890	5	GIMAP5	7	150440111	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08	49863	150440111	8698552	30	9324											
XKR5	389610	broad.mit.edu	37	chr8	6681094	6681094	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttgtagaacagaaccagacTcagcacgcgggttcccaaca	9	12	1	3			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr8:6681094T>A	uc003wqp.2	-	4	608	c.586A>T	c.(586-588)AGT>TGT	p.S196C	XKR5_uc003wqq.2_Missense_Mutation_p.S33C|XKR5_uc003wqr.1_RNA	NM_207411	NP_997294	Q6UX68	XKR5_HUMAN	XK-related protein 5a	196						integral to membrane					0			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		AGAACCAGACTCAGCACGCGG	0.483													A	6681094	A	A	6681094	3	1	135	1	0	0	0	0	1	0	0	0	17431	1551	54	5	1491	5	XKR5	8	6681094	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08		6681094	139682928	31	9325											
PTPRD	5789	broad.mit.edu	37	chr9	8389318	8389318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccaaaagtccccaaatgtttCggggagagatccctgtgttg	11	10	0	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr9:8389318C>T	uc003zkk.2	-	36	5011	c.4300G>A	c.(4300-4302)GAA>AAA	p.E1434K	PTPRD_uc003zkp.2_Missense_Mutation_p.E1028K|PTPRD_uc003zkq.2_Missense_Mutation_p.E1027K|PTPRD_uc003zkr.2_Missense_Mutation_p.E1018K|PTPRD_uc003zks.2_Missense_Mutation_p.E1027K|PTPRD_uc003zkl.2_Missense_Mutation_p.E1425K|PTPRD_uc003zkm.2_Missense_Mutation_p.E1421K|PTPRD_uc003zkn.2_Missense_Mutation_p.E1023K|PTPRD_uc003zko.2_Missense_Mutation_p.E1024K	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1434	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CCAAATGTTTCGGGGAGAGAT	0.418										TSP Lung(15;0.13)			T	8389318	T	T	8389318	3	4	135	1	0	0	0	0	1	0	0	0	12799	893	31	2	1478	2	PTPRD	9	8389318	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08		8389318	132824113	32	9326											
SLC28A3	64078	broad.mit.edu	37	chr9	86924627	86924627	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcaactgtgacctgttcttcAtcctggaaatcaaacattgg	7	10	4	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr9:86924627A>T	uc010mpz.2	-	3	284	c.159T>A	c.(157-159)GAT>GAA	p.D53E	SLC28A3_uc011lsy.1_5'UTR|SLC28A3_uc004anu.1_Missense_Mutation_p.D53E|SLC28A3_uc010mqb.2_5'UTR	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	53	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						CCTGTTCTTCATCCTGGAAAT	0.428													T	86924627	T	T	86924627	3	4	135	1	0	0	0	0	1	0	0	0	14533	214	8	5	1980	5	SLC28A3	9	86924627	Missense_Mutation	SNP	A	TCGA-14-0871-01A-01W-0424-08	78535309	86924627	54288804	33	9327											
KIAA1958	158405	broad.mit.edu	37	chr9	115336719	115336719	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	taaccggaccagagactcttGtgacttctcctactgtagtg	9	11	2	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr9:115336719G>T	uc004bgf.1	+	2	534	c.359G>T	c.(358-360)TGT>TTT	p.C120F	KIAA1958_uc011lwx.1_Missense_Mutation_p.C120F	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	120										skin(1)	1						AGAGACTCTTGTGACTTCTCC	0.473													T	115336719	T	T	115336719	3	4	135	1	0	0	0	0	1	0	0	0	8264	1377	48	5	361	5	KIAA1958	9	115336719	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	28412092	115336719	25876712	34	9328											
OR5AR1	219493	broad.mit.edu	37	chr11	56431364	56431364	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttcctctgcaacctctcctTtgttgacctgggctactcct	6	15	2	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr11:56431364T>G	uc010rjm.1	+	1	203	c.203T>G	c.(202-204)TTT>TGT	p.F68C		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AACCTCTCCTTTGTTGACCTG	0.463													G	56431364	G	G	56431364	3	3	135	1	0	0	0	0	1	0	0	0	11145	1841	64	5	205	5	OR5AR1	11	56431364	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08		56431364	78575152	35	9329											
OSBP	5007	broad.mit.edu	37	chr11	59376014	59376014	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gctcgttcgttgacctgtttGatcttttcattgctctcagc	8	11	3	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr11:59376014G>A	uc001noc.1	-	3	1245	c.765C>T	c.(763-765)ATC>ATT	p.I255I		NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	255					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TGACCTGTTTGATCTTTTCAT	0.478													A	59376014	A	A	59376014	2	1	135	1	0	0	0	0	0	0	0	1	11273	1280	45	3		3	OSBP	11	59376014	Silent	SNP	G	TCGA-14-0871-01A-01W-0424-08	2944650	59376014	75630502	36	9330											
CTSF	8722	broad.mit.edu	37	chr11	66333870	66333870	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaagacggacaggcgccaccGggcttctgaggaccaaggag	15	11	1	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr11:66333870G>C	uc001oip.2	-	5	703	c.613C>G	c.(613-615)CGG>GGG	p.R205G		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	205					proteolysis	lysosome	cysteine-type endopeptidase activity				0						AGGCGCCACCGGGCTTCTGAG	0.587													C	66333870	C	C	66333870	3	2	135	1	0	0	0	0	1	0	0	0	4034	1115	39	5	877	5	CTSF	11	66333870	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	6957856	66333870	68672646	37	9331											
WNT11	7481	broad.mit.edu	37	chr11	75907584	75907584	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatggaggagcagttccagcGcatgtcggcaaaggcccggc	15	11	0	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr11:75907584G>A	uc001oxe.2	-	2	385	c.262C>T	c.(262-264)CGC>TGC	p.R88C	WNT11_uc001oxf.1_Missense_Mutation_p.R88C	NM_004626	NP_004617	O96014	WNT11_HUMAN	wingless-type MMTV integration site family,	88					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			lung(1)|skin(1)	2						CAGTTCCAGCGCATGTCGGCA	0.632													A	75907584	A	A	75907584	3	1	135	1	0	0	0	0	1	0	0	0	17381	1087	38	1	818	1	WNT11	11	75907584	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	9573714	75907584	59098932	38	9332											
SLC2A14	144195	broad.mit.edu	37	chr12	7970576	7970576	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggtccaatttcaaaacaggCcacaaagaccaagatagccc	7	12	1	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr12:7970576C>A	uc001qtk.2	-	15	1988	c.1195G>T	c.(1195-1197)GCC>TCC	p.A399S	SLC2A14_uc001qtl.2_Missense_Mutation_p.A376S|SLC2A14_uc001qtm.2_Missense_Mutation_p.A376S|SLC2A14_uc010sgg.1_Missense_Mutation_p.A290S|SLC2A14_uc001qtn.2_Missense_Mutation_p.A399S|SLC2A14_uc001qto.2_Missense_Mutation_p.A34S|SLC2A14_uc010sgh.1_Missense_Mutation_p.A414S	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	399	Helical; Name=10; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		TCAAAACAGGCCACAAAGACC	0.498													A	7970576	A	A	7970576	3	1	135	1	0	0	0	0	1	0	0	0	14543	739	26	5	375	5	SLC2A14	12	7970576	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08		7970576	125881319	39	9333											
WIF1	11197	broad.mit.edu	37	chr12	65460443	65460443	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttgtcacagttcactccataGaatccaggtgggcagatgca	10	10	2	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr12:65460443G>T	uc001ssk.2	-	6	853	c.708C>A	c.(706-708)TTC>TTA	p.F236L		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	236	EGF-like 2.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		TCACTCCATAGAATCCAGGTG	0.373			T	HMGA2	pleomorphic salivary gland adenoma								T	65460443	T	T	65460443	3	4	135	1	0	0	0	0	1	0	0	0	17363	933	33	5	451	5	WIF1	12	65460443	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	57489867	65460443	68391452	40	9334											
SCARB1	949	broad.mit.edu	37	chr12	125296422	125296422	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctctcgcccctcaccttgctCagcccgttccacttgtccac	5	21	3	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr12:125296422C>T	uc001ugo.3	-	5	973	c.720G>A	c.(718-720)CTG>CTA	p.L240L	SCARB1_uc001ugn.3_Silent_p.L240L|SCARB1_uc001ugm.3_Silent_p.L240L|SCARB1_uc010tbd.1_Silent_p.L240L|SCARB1_uc010tbe.1_Silent_p.L199L|SCARB1_uc001ugp.3_Silent_p.L240L	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	240	Extracellular (Potential).				adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	TCACCTTGCTCAGCCCGTTCC	0.652													T	125296422	T	T	125296422	2	4	135	1	0	0	0	0	0	0	0	1	13881	813	29	3		3	SCARB1	12	125296422	Silent	SNP	C	TCGA-14-0871-01A-01W-0424-08	59835979	125296422	8555473	41	9335											
TMEM132B	114795	broad.mit.edu	37	chr12	126138507	126138507	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	accaggagagagcagtccagGaatggttccaccgtggcaca	13	11	0	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr12:126138507G>T	uc001uhe.1	+	9	2496	c.2488G>T	c.(2488-2490)GAA>TAA	p.E830*	TMEM132B_uc001uhf.1_Nonsense_Mutation_p.E342*	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	830	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGCAGTCCAGGAATGGTTCCA	0.488													T	126138507	T	T	126138507	4	4	135	1	0	0	0	0	0	1	0	0	16043	1175	41	5	2522	5	TMEM132B	12	126138507	Nonsense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	842085	126138507	7713388	42	9336											
GPC6	10082	broad.mit.edu	37	chr13	94680086	94680086	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaacaactactgtctcaAcgtcatgaagggctgcttgg	10	11	2	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr13:94680086A>G	uc001vlt.2	+	4	1447	c.815A>G	c.(814-816)AAC>AGC	p.N272S	GPC6_uc010tig.1_Missense_Mutation_p.N272S	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	272						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				TACTGTCTCAACGTCATGAAG	0.527													G	94680086	G	G	94680086	3	3	135	1	0	0	0	0	1	0	0	0	6602	43	2	4	829	4	GPC6	13	94680086	Missense_Mutation	SNP	A	TCGA-14-0871-01A-01W-0424-08		94680086	20489792	43	9337											
FANCM	57697	broad.mit.edu	37	chr14	45620712	45620712	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagagatcagtttaggaaaaAcccatctccgaatattgtgg	9	7	2	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr14:45620712A>T	uc001wwd.3	+	5	1130	c.1031A>T	c.(1030-1032)AAC>ATC	p.N344I	FANCM_uc001wwc.2_Missense_Mutation_p.N344I|FANCM_uc010anf.2_Missense_Mutation_p.N318I	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	344					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TTTAGGAAAAACCCATCTCCG	0.318								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				T	45620712	T	T	45620712	3	4	135	1	0	0	0	0	1	0	0	0	5671	43	2	5	1049	5	FANCM	14	45620712	Missense_Mutation	SNP	A	TCGA-14-0871-01A-01W-0424-08		45620712	61728828	44	9338											
ACTN1	87	broad.mit.edu	37	chr14	69349623	69349623	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ccattgatctcctgaggcgtGatggttgtgtaggggttggt	16	6	1	3			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr14:69349623G>A	uc001xkl.2	-	15	2095	c.1785C>T	c.(1783-1785)ATC>ATT	p.I595I	ACTN1_uc001xkk.2_Silent_p.I191I|ACTN1_uc010ttb.1_Silent_p.I530I|ACTN1_uc001xkm.2_Silent_p.I595I|ACTN1_uc001xkn.2_Silent_p.I595I|ACTN1_uc010ttc.1_Silent_p.I180I	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	595	Interaction with DDN.|Spectrin 3.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CCTGAGGCGTGATGGTTGTGT	0.517													A	69349623	A	A	69349623	2	1	135	1	0	0	0	0	0	0	0	1	204	1280	45	3		3	ACTN1	14	69349623	Silent	SNP	G	TCGA-14-0871-01A-01W-0424-08	23728911	69349623	37999917	45	9339											
DICER1	23405	broad.mit.edu	37	chr14	95557629	95557629	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaatggcaccagcaagcgacTcaaaaatatcccccatggcc	7	14	1	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr14:95557629T>C	uc001ydw.2	-	26	5620	c.5438A>G	c.(5437-5439)GAG>GGG	p.E1813G	DICER1_uc010avh.1_Missense_Mutation_p.E711G|DICER1_uc001ydv.2_Missense_Mutation_p.E1803G|DICER1_uc001ydx.2_Missense_Mutation_p.E1813G	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1813	RNase III 2.	Magnesium or manganese 2.		E->A: Decreased activity. Loss of activity; when associated with E-1444.	negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AGCAAGCGACTCAAAAATATC	0.458			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				C	95557629	C	C	95557629	3	2	135	1	0	0	0	0	1	0	0	0	4521	1551	54	4	342	4	DICER1	14	95557629	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08	26208006	95557629	11791911	46	9340											
NOX5	79400	broad.mit.edu	37	chr15	69347743	69347743	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgacatgaaggccattggccTgcagatggcccttgacctcc	11	13	0	4			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr15:69347743T>A	uc002ars.1	+	15	2089	c.2069T>A	c.(2068-2070)CTG>CAG	p.L690Q	NOX5_uc002arp.1_Missense_Mutation_p.L672Q|NOX5_uc002arq.1_Missense_Mutation_p.L644Q|NOX5_uc010bid.1_Missense_Mutation_p.L655Q|NOX5_uc002arr.1_Missense_Mutation_p.L662Q|NOX5_uc010bie.1_Missense_Mutation_p.L490Q|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	690	Extracellular (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						GCCATTGGCCTGCAGATGGCC	0.597													A	69347743	A	A	69347743	3	1	135	1	0	0	0	0	1	0	0	0	10559	1580	55	5	2160	5	NOX5	15	69347743	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08		69347743	33183649	47	9341											
UNC45A	55898	broad.mit.edu	37	chr15	91488293	91488293	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actttgtgaaaactacatcaAgtaaggaagtctgtttcacc	7	8	3	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr15:91488293A>G	uc002bqg.2	+	9	1539	c.1199A>G	c.(1198-1200)AAG>AGG	p.K400R	UNC45A_uc002bqd.2_Missense_Mutation_p.K385R|UNC45A_uc010uqr.1_5'Flank	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	400					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AACTACATCAAGTAAGGAAGT	0.478													G	91488293	G	G	91488293	3	3	135	1	0	0	0	0	1	0	0	0	16985	86	3	4	1233	4	UNC45A	15	91488293	Missense_Mutation	SNP	A	TCGA-14-0871-01A-01W-0424-08	22140550	91488293	11043099	48	9342											
RUNDC2A	84127	broad.mit.edu	37	chr16	12145796	12145796	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgagcagaactctggggacGtgtttaaaaagacacctggg	13	7	1	3			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr16:12145796G>A	uc002dbw.1	+	8	903	c.841G>A	c.(841-843)GTG>ATG	p.V281M	SNX29_uc002dby.3_5'Flank	NM_032167	NP_115543	Q9HA26	RUN2A_HUMAN	RUN domain containing 2A	281										ovary(1)	1						CTCTGGGGACGTGTTTAAAAA	0.483			T	CIITA	PMBL|Hodgkin Lymphona|								A	12145796	A	A	12145796	3	1	135	1	0	0	0	0	1	0	0	0	13743	1145	40	1	871	1	RUNDC2A	16	12145796	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08		12145796	78208957	49	9343											
AKTIP	64400	broad.mit.edu	37	chr16	53528141	53528141	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aactttacttttaaaaagctGaatatctttttcatacctgt	3	7	2	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr16:53528141G>A	uc002ehk.2	-	8	830	c.619C>T	c.(619-621)CAG>TAG	p.Q207*	AKTIP_uc002ehl.2_Nonsense_Mutation_p.Q207*|AKTIP_uc002ehm.2_Nonsense_Mutation_p.Q207*	NM_001012398	NP_001012398	Q9H8T0	AKTIP_HUMAN	AKT interacting protein	207					apoptosis|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|positive regulation of protein binding|positive regulation of protein phosphorylation|protein transport	FHF complex|plasma membrane	acid-amino acid ligase activity|protein binding				0		all_cancers(37;0.14)				TTAAAAAGCTGAATATCTTTT	0.308													A	53528141	A	A	53528141	4	1	135	1	0	0	0	0	0	1	0	0	482	1299	45	3	271	3	AKTIP	16	53528141	Nonsense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	41382345	53528141	36826612	50	9344											
CDH16	1014	broad.mit.edu	37	chr16	66946227	66946227	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgtctcccctctcaatgGcaaaatccatgaggcggaag	10	12	2	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr16:66946227G>A	uc002eql.2	-	12	1539	c.1466C>T	c.(1465-1467)GCC>GTC	p.A489V	CDH16_uc010cdy.2_Missense_Mutation_p.A489V|CDH16_uc002eqm.2_Missense_Mutation_p.A392V	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	489	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CCTCTCAATGGCAAAATCCAT	0.577													A	66946227	A	A	66946227	3	1	135	1	0	0	0	0	1	0	0	0	3101	1203	42	3	1051	3	CDH16	16	66946227	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	13418086	66946227	23408526	51	9345											
WWP2	11060	broad.mit.edu	37	chr16	69973830	69973830	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cattgaggagaccgagggctTtggacaggagtaaccgaggc	16	8	0	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr16:69973830T>C	uc002exu.1	+	25	2689	c.2600T>C	c.(2599-2601)TTT>TCT	p.F867S	WWP2_uc002exv.1_Missense_Mutation_p.F867S|WWP2_uc010vlm.1_Missense_Mutation_p.F751S|WWP2_uc010vln.1_Missense_Mutation_p.F485S|WWP2_uc002exw.1_Missense_Mutation_p.F428S	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	867	HECT.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						ACCGAGGGCTTTGGACAGGAG	0.612													C	69973830	C	C	69973830	3	2	135	1	0	0	0	0	1	0	0	0	17413	1841	64	4	2694	4	WWP2	16	69973830	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08	3027603	69973830	20380923	52	9346											
TP53	7157	broad.mit.edu	37	chr17	7577035	7577036	+	Frame_Shift_Ins	INS	-	G	G													tacctcgcttagtgctccctINSgggggcagctcgtggtgagg					rs72661120		TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr17:7577035_7577036insG	uc002gim.2	-	8	1096_1097	c.902_903insC	c.(901-903)CCAfs	p.P301fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Ins_p.P301fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.P169fs|TP53_uc010cng.1_Frame_Shift_Ins_p.P169fs|TP53_uc002gii.1_Frame_Shift_Ins_p.P169fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.P301fs|TP53_uc010cni.1_Frame_Shift_Ins_p.P301fs|TP53_uc002gij.2_Frame_Shift_Ins_p.P301fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	301	Interaction with HIPK1 (By similarity).|Interaction with CARM1.		P -> T (in a sporadic cancer; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P301fs*44(9)|p.0?(7)|p.G302fs*4(4)|p.?(3)|p.P301fs*5(3)|p.P301S(3)|p.P301_S303delPGS(1)|p.L299fs*2(1)|p.L265_K305del41(1)|p.P301Q(1)|p.P301P(1)|p.P301fs*45(1)|p.P301T(1)|p.G293fs*1(1)|p.P301L(1)|p.P301A(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TAGTGCTCCCTGGGGGCAGCTC	0.559		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			G	7577036	G	G	7577035	7	5	135	1	0	1	1	0	0	0	0	0	16378	1567	55	0	383	0	TP53	17	7577035	Frame_Shift_Ins	INS	-	TCGA-14-0871-01A-01W-0424-08		7577035	73618175	53	9347											
NF1	4763	broad.mit.edu	37	chr17	29557336	29557336	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaataaaaacgaaactgtgtCaattagttgaagtaatgatg	8	3	1	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr17:29557336C>T	uc002hgg.2	+	23	3382	c.3049C>T	c.(3049-3051)CAA>TAA	p.Q1017*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q1017*|NF1_uc010csn.1_Nonsense_Mutation_p.Q877*|NF1_uc002hgi.1_Nonsense_Mutation_p.Q50*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1017					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)|p.Q1017*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GAAACTGTGTCAATTAGTTGA	0.338			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29557336	T	T	29557336	4	4	135	1	0	0	0	0	0	1	0	0	10356	827	29	3	3200	3	NF1	17	29557336	Nonsense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	21980301	29557336	51637874	54	9348											
GAS2L2	246176	broad.mit.edu	37	chr17	34072639	34072639	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgcgagggatgaccccagacCttgtgccctgcggacaggca	14	13	0	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr17:34072639C>G	uc002hjv.1	-	6	1905	c.1877G>C	c.(1876-1878)AGG>ACG	p.R626T		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	626					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GACCCCAGACCTTGTGCCCTG	0.582													G	34072639	G	G	34072639	3	3	135	1	0	0	0	0	1	0	0	0	6247	681	24	5	769	5	GAS2L2	17	34072639	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	4515303	34072639	47122571	55	9349											
TUBG2	27175	broad.mit.edu	37	chr17	40817702	40817702	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acgcctgtccccaggtgtccAccatcatgtcggccagcacc	9	18	1	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr17:40817702A>G	uc010wgr.1	+	8	956	c.700A>G	c.(700-702)ACC>GCC	p.T234A	TUBG2_uc002iaq.2_Missense_Mutation_p.T76A|TUBG2_uc002iar.2_Missense_Mutation_p.T81A|TUBG2_uc002ias.2_Missense_Mutation_p.T76A|TUBG2_uc002iap.2_Missense_Mutation_p.T81A	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	234					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		CCAGGTGTCCACCATCATGTC	0.637													G	40817702	G	G	40817702	3	3	135	1	0	0	0	0	1	0	0	0	16762	159	6	4	730	4	TUBG2	17	40817702	Missense_Mutation	SNP	A	TCGA-14-0871-01A-01W-0424-08	6745063	40817702	40377508	56	9350											
WNK4	65266	broad.mit.edu	37	chr17	40939868	40939868	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agaccctgcccttcagccccCtgggggggtgccatccagcc	12	18	1	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr17:40939868C>A	uc002ibj.2	+	8	1835	c.1814C>A	c.(1813-1815)CCT>CAT	p.P605H	WNK4_uc010wgx.1_Missense_Mutation_p.P269H|WNK4_uc002ibk.1_Missense_Mutation_p.P377H|WNK4_uc010wgy.1_Intron	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	605					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CTTCAGCCCCCTGGGGGGGTG	0.632													A	40939868	A	A	40939868	3	1	135	1	0	0	0	0	1	0	0	0	17377	681	24	5	1844	5	WNK4	17	40939868	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	122166	40939868	40255342	57	9351											
C18orf34	374864	broad.mit.edu	37	chr18	30873224	30873224	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aatattagtattaacatttaTcactgatgaagagtaatgat	6	3	1	4			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr18:30873224T>A	uc002kxn.2	-	11	1217	c.1075A>T	c.(1075-1077)ATA>TTA	p.I359L	C18orf34_uc010xbr.1_Missense_Mutation_p.I359L|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.I359L|C18orf34_uc002kxp.2_Missense_Mutation_p.I359L	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	359	Potential.									ovary(1)	1						TTAACATTTATCACTGATGAA	0.274													A	30873224	A	A	30873224	3	1	135	1	0	0	0	0	1	0	0	0	1902	1435	50	5	1576	5	C18orf34	18	30873224	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08		30873224	47204024	58	9352											
C19orf2	8725	broad.mit.edu	37	chr19	30476136	30476136	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttctgtcaacaggaagaaGgtagataatgactataatgc	9	5	2	3			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr19:30476136G>A	uc002nsr.2	+	3	189	c.159G>A	c.(157-159)AAG>AAA	p.K53K	C19orf2_uc002nsq.2_Silent_p.K35K|C19orf2_uc002nss.2_Silent_p.K13K|C19orf2_uc002nst.2_5'UTR	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	53					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		ACAGGAAGAAGGTAGATAATG	0.244													A	30476136	A	A	30476136	2	1	135	1	0	0	0	0	0	0	0	1	1911	991	35	3		3	C19orf2	19	30476136	Silent	SNP	G	TCGA-14-0871-01A-01W-0424-08		30476136	28652847	59	9353											
WDR88	126248	broad.mit.edu	37	chr19	33651345	33651345	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttctcatttctggagggttTgataggactgtggctatttg	12	5	2	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr19:33651345T>A	uc002nui.2	+	8	1101	c.1023T>A	c.(1021-1023)TTT>TTA	p.F341L		NM_173479	NP_775750	Q6ZMY6	WDR88_HUMAN	PQQ repeat and WD repeat domain containing	341	WD 6.									ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)					CTGGAGGGTTTGATAGGACTG	0.493													A	33651345	A	A	33651345	3	1	135	1	0	0	0	0	1	0	0	0	17332	1809	63	5	1053	5	WDR88	19	33651345	Missense_Mutation	SNP	T	TCGA-14-0871-01A-01W-0424-08	3175209	33651345	25477638	60	9354											
KCTD15	79047	broad.mit.edu	37	chr19	34292103	34292103	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtcccggctgtctctcaCccggtcgcctgtgtctcccc	9	19	3	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr19:34292103C>T	uc002nuy.3	+	4	366	c.98C>T	c.(97-99)ACC>ATC	p.T33I	KCTD15_uc002nuv.2_Missense_Mutation_p.T33I|KCTD15_uc002nuw.3_Missense_Mutation_p.T33I|KCTD15_uc010xrt.1_Missense_Mutation_p.T33I|KCTD15_uc002nux.3_Missense_Mutation_p.T33I	NM_001129994	NP_001123466	Q96SI1	KCD15_HUMAN	potassium channel tetramerisation domain	33						voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	Esophageal squamous(110;0.162)					CTGTCTCTCACCCGGTCGCCT	0.582													T	34292103	T	T	34292103	3	4	135	1	0	0	0	0	1	0	0	0	8102	507	18	3	104	3	KCTD15	19	34292103	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08	640758	34292103	24836880	61	9355											
ZNF470	388566	broad.mit.edu	37	chr19	57088457	57088457	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttgtgaaaaaacacaagcaAgaccgtggagaaaagaaact	10	6	0	4			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr19:57088457A>G	uc002qnl.3	+	6	1336	c.660A>G	c.(658-660)CAA>CAG	p.Q220Q	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AACACAAGCAAGACCGTGGAG	0.308													G	57088457	G	G	57088457	2	3	135	1	0	0	0	0	0	0	0	1	17926	69	3	4		4	ZNF470	19	57088457	Silent	SNP	A	TCGA-14-0871-01A-01W-0424-08	22796354	57088457	2040526	62	9356											
ZNF324	25799	broad.mit.edu	37	chr19	58983498	58983498	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcctcgggcccagccgccGtctcgcagccagcggaggtc	14	19	1	0			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr19:58983498G>A	uc002qsw.1	+	4	1733	c.1639G>A	c.(1639-1641)GTC>ATC	p.V547I	ZNF324_uc002qsx.1_Missense_Mutation_p.V324I	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	547					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CCCAGCCGCCGTCTCGCAGCC	0.652													A	58983498	A	A	58983498	3	1	135	1	0	0	0	0	1	0	0	0	17841	1145	40	1	1649	1	ZNF324	19	58983498	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08	1895041	58983498	145485	63	9357											
KRTAP10-9	386676	broad.mit.edu	37	chr21	46047750	46047750	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgccagccggcttgctgcaCcacctcctgctgcagaccct	9	19	0	1			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chr21:46047750C>A	uc002zfp.3	+	1	711	c.662C>A	c.(661-663)ACC>AAC	p.T221N	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	221	22.|25 X 5 AA repeats of C-C-X(3).					keratin filament					0						GCTTGCTGCACCACCTCCTGC	0.657													A	46047750	A	A	46047750	3	1	135	1	0	0	0	0	1	0	0	0	8516	507	18	5	664	5	KRTAP10-9	21	46047750	Missense_Mutation	SNP	C	TCGA-14-0871-01A-01W-0424-08		46047750	2082145	64	9358											
NUP62CL	54830	broad.mit.edu	37	chrX	106397360	106397360	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caatcaatgtatggtcccaaGcattgacctgagtggcctgg	11	10	1	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chrX:106397360G>C	uc004ena.2	-	5	570	c.311C>G	c.(310-312)GCT>GGT	p.A104G	NUP62CL_uc004enb.2_Intron	NM_017681	NP_060151	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	104					protein transport	nuclear pore	structural constituent of nuclear pore				0						ATGGTCCCAAGCATTGACCTG	0.388													C	106397360	C	C	106397360	3	2	135	1	0	0	0	0	1	0	0	0	10769	971	34	5	259	5	NUP62CL	23	106397360	Missense_Mutation	SNP	G	TCGA-14-0871-01A-01W-0424-08		106397360	48873200	65	9359											
UBE2NL	389898	broad.mit.edu	37	chrX	142967486	142967487	+	Missense_Mutation	DNP	AG	TA	TA													tttagatattttgaaagataAgtggtccccagccctgcaga							TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chrX:142967486_142967487AG>TA	uc004fca.2	+	1	314_315	c.284_285AG>TA	c.(283-285)AAG>ATA	p.K95I		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	95							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					TTGAAAGATAAGTGGTCCCCAG	0.421													TA	142967487	TA	TA	142967486	3	4	135	1	0	0	0	0	1	0	0	0	16864	72	3	5	286	5	UBE2NL	23	142967486	Missense_Mutation	DNP	AG	TCGA-14-0871-01A-01W-0424-08	36570126	142967486	12303074	66	9360											
GABRQ	55879	broad.mit.edu	37	chrX	151808911	151808911	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tcaagatacgatgtccgcctGagaccgaattttggaggtaa	11	8	1	2			TCGA-14-0871-01A-01W-0424-08	TCGA-14-0871-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	0cc45f48-0967-42dc-8035-e76c6bd0a3fd	7b4f35d6-c654-4632-9738-9e80fc483b97	g.chrX:151808911G>A	uc004ffp.1	+	2	242	c.222G>A	c.(220-222)CTG>CTA	p.L74L		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	74	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATGTCCGCCTGAGACCGAATT	0.463													A	151808911	A	A	151808911	2	1	135	1	0	0	0	0	0	0	0	1	6175	1277	45	3		3	GABRQ	23	151808911	Silent	SNP	G	TCGA-14-0871-01A-01W-0424-08	8841425	151808911	3461649	67	9361											
MPL	4352	broad.mit.edu	37	chr1	43804269	43804269	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	catgccccactttggaacccGatacgtgtgccagtttccag	9	14	0	0			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr1:43804269G>A	uc001ciw.2	+	3	314	c.269G>A	c.(268-270)CGA>CAA	p.R90Q	MPL_uc001civ.2_Missense_Mutation_p.R90Q|MPL_uc009vwr.2_Missense_Mutation_p.R83Q	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	90	Extracellular (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTTGGAACCCGATACGTGTGC	0.572			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						A	43804269	A	A	43804269	3	1	136	1	0	0	0	0	1	0	0	0	9730	1058	37	2	279	2	MPL	1	43804269	Missense_Mutation	SNP	G	TCGA-14-1043-01B-11D-1845-08		43804269	205446352	1	9362											
C1orf104	284618	broad.mit.edu	37	chr1	155291139	155291139	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggtcccttcctctgggaGtaaggggtaggctggagggc	18	9	1	0			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr1:155291139G>A	uc001fki.2	-	2	418	c.141C>T	c.(139-141)TAC>TAT	p.Y47Y	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_RNA|RUSC1_uc001fkj.2_Intron|RUSC1_uc001fkk.2_Intron|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank	NM_001039517	NP_001034606	Q66K80	RUAS1_HUMAN	hypothetical protein LOC284618	47											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TCCTCTGGGAGTAAGGGGTAG	0.647													A	155291139	A	A	155291139	2	1	136	1	0	0	0	0	0	0	0	1	1978	1024	36	3		3	C1orf104	1	155291139	Silent	SNP	G	TCGA-14-1043-01B-11D-1845-08	111486870	155291139	93959482	2	9363											
SPTA1	6708	broad.mit.edu	37	chr1	158617395	158617395	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctccttacgatcctttgtaCgcccctgcaggtcttcccag	7	16	2	0			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr1:158617395C>T	uc001fst.1	-	27	4029	c.3830G>A	c.(3829-3831)CGT>CAT	p.R1277H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1277	Spectrin 12.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ATCCTTTGTACGCCCCTGCAG	0.557													T	158617395	T	T	158617395	3	4	136	1	0	0	0	0	1	0	0	0	15115	536	19	1	3533	1	SPTA1	1	158617395	Missense_Mutation	SNP	C	TCGA-14-1043-01B-11D-1845-08	3326256	158617395	90633226	3	9364											
CEP350	9857	broad.mit.edu	37	chr1	179989186	179989186	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ggaacagctggaagtttactCtcccatctcttgagtttaga	9	9	2	2			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr1:179989186C>G	uc001gnt.2	+	12	2660	c.2277C>G	c.(2275-2277)CTC>CTG	p.L759L	CEP350_uc009wxl.2_Silent_p.L758L|CEP350_uc001gnu.2_Silent_p.L593L	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	759						centrosome|nucleus|spindle				ovary(4)	4						GAAGTTTACTCTCCCATCTCT	0.403													G	179989186	G	G	179989186	2	3	136	1	0	0	0	0	0	0	0	1	3254	900	32	5		5	CEP350	1	179989186	Silent	SNP	C	TCGA-14-1043-01B-11D-1845-08	21371791	179989186	69261435	4	9365											
CAMKV	79012	broad.mit.edu	37	chr3	49896857	49896857	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctctggggctgtgctgtccGgctgggccatagccggctca	15	14	2	0			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr3:49896857G>T	uc003cxt.1	-	11	1593	c.1400C>A	c.(1399-1401)CCG>CAG	p.P467Q	TRAIP_uc003cxs.1_5'Flank|TRAIP_uc010hla.1_5'Flank|TRAIP_uc011bcx.1_5'Flank|CAMKV_uc011bcy.1_Missense_Mutation_p.P392Q|CAMKV_uc003cxv.1_Missense_Mutation_p.P439Q|CAMKV_uc003cxw.1_Missense_Mutation_p.P299Q|CAMKV_uc003cxx.1_Missense_Mutation_p.P299Q|CAMKV_uc003cxu.2_Missense_Mutation_p.P436Q|CAMKV_uc011bcz.1_Missense_Mutation_p.P399Q|CAMKV_uc011bda.1_Missense_Mutation_p.P393Q	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	467	Ala-rich.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TGTGCTGTCCGGCTGGGCCAT	0.652													T	49896857	T	T	49896857	3	4	136	1	0	0	0	0	1	0	0	0	2608	1116	39	5	109	5	CAMKV	3	49896857	Missense_Mutation	SNP	G	TCGA-14-1043-01B-11D-1845-08		49896857	148125573	5	9366											
C3orf26	84319	broad.mit.edu	37	chr3	99891168	99891168	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcttggaacaggtccaggcGcaggtaaagttgctggagaa	14	7	1	1			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr3:99891168G>A	uc003dtl.2	+	8	731	c.588G>A	c.(586-588)GCG>GCA	p.A196A		NM_032359	NP_115735	Q9BQ75	CC026_HUMAN	hypothetical protein LOC84319	196							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1						AGGTCCAGGCGCAGGTAAAGT	0.413													A	99891168	A	A	99891168	2	1	136	1	0	0	0	0	0	0	0	1	2218	1074	38	1		1	C3orf26	3	99891168	Silent	SNP	G	TCGA-14-1043-01B-11D-1845-08	49994311	99891168	98131262	6	9367											
FXR1	8087	broad.mit.edu	37	chr3	180651171	180651172	+	Frame_Shift_Del	DEL	AT	-	-													ccttacagttgtttttgaaaAtaagtaagttatttttgttg							TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr3:180651171_180651172delAT	uc003fkq.2	+	2	123_124	c.101_102delAT	c.(100-102)AATfs	p.N34fs	FXR1_uc003fkp.2_5'UTR|FXR1_uc003fkr.2_Frame_Shift_Del_p.N34fs|FXR1_uc011bqj.1_Intron|FXR1_uc003fks.2_5'UTR|FXR1_uc011bqk.1_Intron|FXR1_uc011bql.1_Frame_Shift_Del_p.N21fs	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	34					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GTTTTTGAAAATAAGTAAGTTA	0.332													-	180651172	-	-	180651171	7	5	136	1	0	1	0	1	0	0	0	0	6115	101	4	0	107	0	FXR1	3	180651171	Frame_Shift_Del	DEL	AT	TCGA-14-1043-01B-11D-1845-08	80760003	180651171	17371259	7	9368											
RICTOR	253260	broad.mit.edu	37	chr5	38950386	38950386	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgattctctgtaccaaaAttcttggtgaattttaagtc	7	7	2	2			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr5:38950386A>C	uc003jlp.2	-	31	3588	c.3564T>G	c.(3562-3564)AAT>AAG	p.N1188K	RICTOR_uc003jlo.2_Missense_Mutation_p.N1188K|RICTOR_uc010ivf.2_Missense_Mutation_p.N903K	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1188					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					CTGTACCAAAATTCTTGGTGA	0.358													C	38950386	C	C	38950386	3	2	136	1	0	0	0	0	1	0	0	0	13358	98	4	5	1594	5	RICTOR	5	38950386	Missense_Mutation	SNP	A	TCGA-14-1043-01B-11D-1845-08		38950386	141964874	8	9369											
SV2C	22987	broad.mit.edu	37	chr5	75427791	75427791	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatggtgaggccaacgatgaCgaaggctcaagtgaagccac	13	9	1	3			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr5:75427791C>T	uc003kei.1	+	2	350	c.216C>T	c.(214-216)GAC>GAT	p.D72D		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	72	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CCAACGATGACGAAGGCTCAA	0.498													T	75427791	T	T	75427791	2	4	136	1	0	0	0	0	0	0	0	1	15416	535	19	1		1	SV2C	5	75427791	Silent	SNP	C	TCGA-14-1043-01B-11D-1845-08	36477405	75427791	105487469	9	9370											
ARRDC3	57561	broad.mit.edu	37	chr5	90671379	90671379	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acttaaggatattgggcctgAggtacagaaccagcaacaga	11	8	0	3			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr5:90671379A>C	uc003kjz.2	-	4	802	c.562T>G	c.(562-564)TCA>GCA	p.S188A		NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	188					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		ATTGGGCCTGAGGTACAGAAC	0.398													C	90671379	C	C	90671379	3	2	136	1	0	0	0	0	1	0	0	0	984	304	11	5	702	5	ARRDC3	5	90671379	Missense_Mutation	SNP	A	TCGA-14-1043-01B-11D-1845-08	15243588	90671379	90243881	10	9371											
CDC23	8697	broad.mit.edu	37	chr5	137524677	137524677	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagtagccaactatggcgtgAcagaagacaagttgagtgga	14	6	0	4			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr5:137524677A>G	uc003lcl.2	-	16	1815	c.1784T>C	c.(1783-1785)GTC>GCC	p.V595A		NM_004661	NP_004652	Q9UJX2	CDC23_HUMAN	cell division cycle protein 23	595					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTATGGCGTGACAGAAGACAA	0.493													G	137524677	G	G	137524677	3	3	136	1	0	0	0	0	1	0	0	0	3061	275	10	4	13	4	CDC23	5	137524677	Missense_Mutation	SNP	A	TCGA-14-1043-01B-11D-1845-08	46853298	137524677	43390583	11	9372											
JAKMIP2	9832	broad.mit.edu	37	chr5	147012259	147012259	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttacttctagctctaggtttCgaaactccagcagctcattc	6	12	3	0			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr5:147012259C>T	uc003loq.1	-	13	2142	c.1760G>A	c.(1759-1761)CGA>CAA	p.R587Q	JAKMIP2_uc011dbx.1_Missense_Mutation_p.R545Q|JAKMIP2_uc003lor.1_Missense_Mutation_p.R566Q|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Missense_Mutation_p.R587Q	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	587	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTAGGTTTCGAAACTCCAG	0.289													T	147012259	T	T	147012259	3	4	136	1	0	0	0	0	1	0	0	0	7941	884	31	2	708	2	JAKMIP2	5	147012259	Missense_Mutation	SNP	C	TCGA-14-1043-01B-11D-1845-08	9487582	147012259	33903001	12	9373											
COL12A1	1303	broad.mit.edu	37	chr6	75866132	75866132	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttccctctcccatgagggcGatagacaacacggtagttga	10	12	1	3			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr6:75866132G>A	uc003phs.2	-	15	3257	c.3091C>T	c.(3091-3093)CGC>TGC	p.R1031C	COL12A1_uc003pht.2_Intron	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1031	Fibronectin type-III 7.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CCATGAGGGCGATAGACAACA	0.473													A	75866132	A	A	75866132	3	1	136	1	0	0	0	0	1	0	0	0	3669	1058	37	2	6308	2	COL12A1	6	75866132	Missense_Mutation	SNP	G	TCGA-14-1043-01B-11D-1845-08		75866132	95248935	13	9374											
CASP8AP2	9994	broad.mit.edu	37	chr6	90578080	90578080	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagatctaacgaaagatccaGtcactgaaaccaaaaacttg	6	9	2	3			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr6:90578080G>A	uc003pnr.2	+	8	5267	c.5071G>A	c.(5071-5073)GTC>ATC	p.V1691I	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.V1691I|CASP8AP2_uc011dzz.1_Missense_Mutation_p.V1691I	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1691					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GAAAGATCCAGTCACTGAAAC	0.388													A	90578080	A	A	90578080	3	1	136	1	0	0	0	0	1	0	0	0	2678	1029	36	3	5097	3	CASP8AP2	6	90578080	Missense_Mutation	SNP	G	TCGA-14-1043-01B-11D-1845-08	14711948	90578080	80536987	14	9375											
PEX1	5189	broad.mit.edu	37	chr7	92147239	92147239	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttccataactatgaagttttTtatattcagcatcagctttt	4	7	2	1			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr7:92147239T>C	uc003uly.2	-	5	686	c.590A>G	c.(589-591)AAA>AGA	p.K197R	PEX1_uc011khr.1_5'UTR|PEX1_uc010ley.2_Missense_Mutation_p.K197R|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	197					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			ATGAAGTTTTTTATATTCAGC	0.388													C	92147239	C	C	92147239	3	2	136	1	0	0	0	0	1	0	0	0	11735	1841	64	4	3341	4	PEX1	7	92147239	Missense_Mutation	SNP	T	TCGA-14-1043-01B-11D-1845-08		92147239	66991424	15	9376											
KIF12	113220	broad.mit.edu	37	chr9	116858751	116858751	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggctgagttccttcgacgGctgagacctggaagggaaaa	15	8	0	2			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr9:116858751G>A	uc004bif.2	-	5	478	c.240C>T	c.(238-240)AGC>AGT	p.S80S	KIF12_uc004big.2_RNA	NM_138424	NP_612433	Q96FN5	KIF12_HUMAN	kinesin family member 12	213	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						TCCTTCGACGGCTGAGAcctg	0.318													A	116858751	A	A	116858751	2	1	136	1	0	0	0	0	0	0	0	1	8273	1194	42	3		3	KIF12	9	116858751	Silent	SNP	G	TCGA-14-1043-01B-11D-1845-08		116858751	24354680	16	9377											
OR5F1	338674	broad.mit.edu	37	chr11	55761884	55761884	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttggggtgatggtagttgagTtacaaacgtccacaaaggac	13	6	0	2			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr11:55761884T>G	uc010riv.1	-	1	218	c.218A>C	c.(217-219)AAC>ACC	p.N73T		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GGTAGTTGAGTTACAAACGTC	0.443													G	55761884	G	G	55761884	3	3	136	1	0	0	0	0	1	0	0	0	11158	1725	60	5	729	5	OR5F1	11	55761884	Missense_Mutation	SNP	T	TCGA-14-1043-01B-11D-1845-08		55761884	79244632	17	9378											
RFX4	5992	broad.mit.edu	37	chr12	107048021	107048021	+	Nonsense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctaggctggaggagaactaTgagattgcagagggggtctg	17	6	1	3			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr12:107048021T>G	uc001tlr.2	+	4	273	c.207T>G	c.(205-207)TAT>TAG	p.Y69*	RFX4_uc010swv.1_RNA|RFX4_uc001tls.2_Nonsense_Mutation_p.Y78*|RFX4_uc001tlt.2_Nonsense_Mutation_p.Y78*	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	69	|RFX-type winged-helix.				transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						AGGAGAACTATGAGATTGCAG	0.468													G	107048021	G	G	107048021	4	3	136	1	0	0	0	0	0	1	0	0	13265	1471	51	5	295	5	RFX4	12	107048021	Nonsense_Mutation	SNP	T	TCGA-14-1043-01B-11D-1845-08		107048021	26803874	18	9379											
NEIL1	79661	broad.mit.edu	37	chr15	75641495	75641495	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccgcttcggcatgtccggCtcttttcagctggtgccccg	11	15	2	0			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr15:75641495C>T	uc002bad.2	+	2	755	c.249C>T	c.(247-249)GGC>GGT	p.G83G	NEIL1_uc002bae.2_Silent_p.G169G	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	83					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						GCATGTCCGGCTCTTTTCAGC	0.687								BER_DNA_glycosylases					T	75641495	T	T	75641495	2	4	136	1	0	0	0	0	0	0	0	1	10318	784	28	3		3	NEIL1	15	75641495	Silent	SNP	C	TCGA-14-1043-01B-11D-1845-08		75641495	26889897	19	9380											
CAMKK1	84254	broad.mit.edu	37	chr17	3779538	3779538	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcccactgaagctctggccGgaatcagaaatggcctcggg	12	12	2	2			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr17:3779538G>A	uc002fwt.2	-	10	1069	c.975C>T	c.(973-975)TCC>TCT	p.S325S	CAMKK1_uc002fwu.2_Silent_p.S325S|CAMKK1_uc002fwv.2_Silent_p.S363S	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	325	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		AGCTCTGGCCGGAATCAGAAA	0.622													A	3779538	A	A	3779538	2	1	136	1	0	0	0	0	0	0	0	1	2606	1103	39	2		2	CAMKK1	17	3779538	Silent	SNP	G	TCGA-14-1043-01B-11D-1845-08		3779538	77415672	20	9381											
NF1	4763	broad.mit.edu	37	chr17	29560133	29560133	+	Frame_Shift_Del	DEL	C	-	-													cagaaacagtattggctgatCggtttgagagattggtggaa							TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr17:29560133delC	uc002hgg.2	+	27	3943	c.3610delC	c.(3610-3612)CGGfs	p.R1204fs	NF1_uc002hgh.2_Frame_Shift_Del_p.R1204fs|NF1_uc010csn.1_Frame_Shift_Del_p.R1064fs|NF1_uc002hgi.1_Frame_Shift_Del_p.R237fs	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1204			R -> W (in NF1).|R -> G (in NF1).		actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)|p.R1204W(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATTGGCTGATCGGTTTGAGAG	0.453			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29560133	-	-	29560133	7	5	136	1	0	1	0	1	0	0	0	0	10356	875	31	0	3777	0	NF1	17	29560133	Frame_Shift_Del	DEL	C	TCGA-14-1043-01B-11D-1845-08	25780595	29560133	51635077	21	9382											
NF1	4763	broad.mit.edu	37	chr17	29661945	29661945	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcataatgatgatgccaaaCgacaaagagttactgctatt	8	7	0	3	rs137854552		TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr17:29661945C>T	uc002hgg.2	+	40	6235	c.5902C>T	c.(5902-5904)CGA>TGA	p.R1968*	NF1_uc002hgh.2_Nonsense_Mutation_p.R1947*|NF1_uc010cso.2_Nonsense_Mutation_p.R156*|NF1_uc010wbt.1_5'Flank|NF1_uc010wbu.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1968					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.R1968*(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGATGCCAAACGACAAAGAGT	0.368			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29661945	T	T	29661945	4	4	136	1	0	0	0	0	0	1	0	0	10356	528	19	1	6121	1	NF1	17	29661945	Nonsense_Mutation	SNP	C	TCGA-14-1043-01B-11D-1845-08	101812	29661945	51533265	22	9383											
HOXB8	3218	broad.mit.edu	37	chr17	46692020	46692020	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aattggggcgcagggactccCcggttttgtatttggagaac	14	8	0	1			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr17:46692020C>G	uc002inw.2	-	1	282	c.47G>C	c.(46-48)GGG>GCG	p.G16A		NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	16						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CAGGGACTCCCCGGTTTTGTA	0.582													G	46692020	G	G	46692020	3	3	136	1	0	0	0	0	1	0	0	0	7307	623	22	5	692	5	HOXB8	17	46692020	Missense_Mutation	SNP	C	TCGA-14-1043-01B-11D-1845-08	17030075	46692020	34503190	23	9384											
MUC16	94025	broad.mit.edu	37	chr19	9062384	9062384	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaaatggaggtcctcacgttGgtcactgctgtgtgtgtgga	15	7	2	0			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr19:9062384G>T	uc002mkp.2	-	3	25266	c.25062C>A	c.(25060-25062)ACC>ACA	p.T8354T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8356	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCTCACGTTGGTCACTGCTG	0.488													T	9062384	T	T	9062384	2	4	136	1	0	0	0	0	0	0	0	1	9973	1335	47	5		5	MUC16	19	9062384	Silent	SNP	G	TCGA-14-1043-01B-11D-1845-08		9062384	50066599	24	9385											
ZNF653	115950	broad.mit.edu	37	chr19	11594572	11594572	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcttctcgaagcgcttcccGcagcgatcgcacgtgaagtt	11	13	1	1			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr19:11594572G>A	uc002mrz.1	-	9	1826	c.1773C>T	c.(1771-1773)TGC>TGT	p.C591C	ELAVL3_uc002mrx.1_5'Flank|ELAVL3_uc002mry.1_5'Flank	NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	591	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGCGCTTCCCGCAGCGATCGC	0.612													A	11594572	A	A	11594572	2	1	136	1	0	0	0	0	0	0	0	1	18063	1079	38	1		1	ZNF653	19	11594572	Silent	SNP	G	TCGA-14-1043-01B-11D-1845-08	2532188	11594572	47534411	25	9386											
FAM83D	81610	broad.mit.edu	37	chr20	37580810	37580811	+	Frame_Shift_Ins	INS	-	T	T													accagtctcaaaaatgtctgINStatcgagatcttccagtttg							TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr20:37580810_37580811insT	uc002xjg.2	+	4	1536_1537	c.1495_1496insT	c.(1495-1497)GTAfs	p.V499fs		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	469	Ser-rich.				cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				AAAAATGTCTGTATCGAGATCT	0.485													T	37580811	T	T	37580810	7	5	136	1	0	1	1	0	0	0	0	0	5636	1377	48	0	1509	0	FAM83D	20	37580810	Frame_Shift_Ins	INS	-	TCGA-14-1043-01B-11D-1845-08		37580810	25444710	26	9387											
PCK1	5105	broad.mit.edu	37	chr20	56140691	56140691	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaggatgccctgaacctgaAaggcctggggcacatcaaca	13	11	1	2			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr20:56140691A>C	uc002xyn.3	+	10	1863	c.1700A>C	c.(1699-1701)AAA>ACA	p.K567T	PCK1_uc010zzm.1_Missense_Mutation_p.K250T	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	567					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CTGAACCTGAAAGGCCTGGGG	0.532													C	56140691	C	C	56140691	3	2	136	1	0	0	0	0	1	0	0	0	11581	14	1	5	1734	5	PCK1	20	56140691	Missense_Mutation	SNP	A	TCGA-14-1043-01B-11D-1845-08	18559881	56140691	6884829	27	9388											
HUNK	30811	broad.mit.edu	37	chr21	33331245	33331245	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttgtaccagaagatggtagaCaaagaaatgaaccccctccc	8	11	0	5			TCGA-14-1043-01B-11D-1845-08	TCGA-14-1043-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a439c422-8728-42f5-8dda-6e9e1590478c	778e0059-412a-40b8-98b4-d3e905f5b905	g.chr21:33331245C>A	uc002yph.2	+	5	1197	c.837C>A	c.(835-837)GAC>GAA	p.D279E		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	279	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						AGATGGTAGACAAAGAAATGA	0.537													A	33331245	A	A	33331245	3	1	136	1	0	0	0	0	1	0	0	0	7458	477	17	5	855	5	HUNK	21	33331245	Missense_Mutation	SNP	C	TCGA-14-1043-01B-11D-1845-08		33331245	14798650	28	9389											
ACOT11	26027	broad.mit.edu	37	chr1	55096492	55096492	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaatccaggtcaaagggtcGcaggagcgacggttggaatg	16	8	1	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr1:55096492G>A	uc001cxm.1	+	16	1797	c.1715G>A	c.(1714-1716)CGC>CAC	p.R572H		NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	572	START.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						tcaaagggtcgcaggagcgac	0													A	55096492	A	A	55096492	3	1	137	1	0	0	0	0	1	0	0	0	149	1087	38	1	1937	1	ACOT11	1	55096492	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08		55096492	194154129	1	9390											
PGM1	5236	broad.mit.edu	37	chr1	64100595	64100595	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctggaggactttggaggcCaccaccctgaccccaacctc	9	17	1	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr1:64100595C>T	uc001dbh.2	+	5	991	c.778C>T	c.(778-780)CAC>TAC	p.H260Y	PGM1_uc010ooy.1_Missense_Mutation_p.H63Y|PGM1_uc010ooz.1_Missense_Mutation_p.H278Y	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	260					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						CTTTGGAGGCCACCACCCTGA	0.547													T	64100595	T	T	64100595	3	4	137	1	0	0	0	0	1	0	0	0	11797	594	21	3	1100	3	PGM1	1	64100595	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	9004103	64100595	185150026	2	9391											
TCHH	7062	broad.mit.edu	37	chr1	152084715	152084735	+	In_Frame_Del	DEL	CTCCTGCTGCTCGCGCCTCTC	-	-													tcctcctgctgctcgcgcctCtcctgctgctcgcgcctctc							TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr1:152084715_152084735delCTCCTGCTGCTCGCGCCTCTC	uc001ezp.2	-	2	958_978	c.958_978delGAGAGGCGCGAGCAGCAGGAG	c.(958-978)GAGAGGCGCGAGCAGCAGGAGdel	p.ERREQQE320del	TCHH_uc009wne.1_In_Frame_Del_p.ERREQQE320del	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	320_326	5 X 13 AA tandem repeats of R-R-E-Q-E-E- E-R-R-E-Q-Q-L.|1-1; approximate.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			gctcgcgcctctcctgctgctcgcgcctctcctcctgctgc	0.072													-	152084735	-	-	152084715	7	5	137	1	0	1	0	1	0	0	0	0	15697	912	32	0	4857	0	TCHH	1	152084715	In_Frame_Del	DEL	CTCCTGCTGCTCGCGCCTCTC	TCGA-14-1395-01B-11D-1845-08	87984120	152084715	97165906	3	9392											
HMCN1	83872	broad.mit.edu	37	chr1	185956668	185956668	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atcccaaaccgtctgtcatcTggtccaaggtaaatgataca	7	11	3	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr1:185956668T>C	uc001grq.1	+	20	3269	c.3040T>C	c.(3040-3042)TGG>CGG	p.W1014R	HMCN1_uc001grr.1_Missense_Mutation_p.W355R	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1014	Ig-like C2-type 7.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTCTGTCATCTGGTCCAAGGT	0.453													C	185956668	C	C	185956668	3	2	137	1	0	0	0	0	1	0	0	0	7220	1580	55	4	3118	4	HMCN1	1	185956668	Missense_Mutation	SNP	T	TCGA-14-1395-01B-11D-1845-08	33871953	185956668	63293953	4	9393											
CFHR5	81494	broad.mit.edu	37	chr1	196964877	196964877	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atcatgtggtccacctcctcAactctccaatggtgaagtta	7	12	3	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr1:196964877A>T	uc001gts.3	+	5	766	c.638A>T	c.(637-639)CAA>CTA	p.Q213L		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	213	Sushi 4.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						CCACCTCCTCAACTCTCCAAT	0.333													T	196964877	T	T	196964877	3	4	137	1	0	0	0	0	1	0	0	0	3288	130	5	5	656	5	CFHR5	1	196964877	Missense_Mutation	SNP	A	TCGA-14-1395-01B-11D-1845-08	11008209	196964877	52285744	5	9394											
OBSCN	84033	broad.mit.edu	37	chr1	228400217	228400217	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccgcccagcaccggcacgCgcacctgcacggtgactgaa	11	18	0	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr1:228400217C>T	uc009xez.1	+	2	777	c.733C>T	c.(733-735)CGC>TGC	p.R245C	OBSCN_uc001hsn.2_Missense_Mutation_p.R245C|uc001hsm.1_Intron	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	245	Ig-like 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CACCGGCACGCGCACCTGCAC	0.746													T	228400217	T	T	228400217	3	4	137	1	0	0	0	0	1	0	0	0	10812	768	27	1	735	1	OBSCN	1	228400217	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	31435340	228400217	20850404	6	9395											
KIAA1804	84451	broad.mit.edu	37	chr1	233511808	233511808	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aagatagaacagattgcaaaGaaaggtacgtgtgtggtatc	12	4	0	4			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr1:233511808G>C	uc001hvt.3	+	7	2083	c.1822G>C	c.(1822-1824)GAA>CAA	p.E608Q	KIAA1804_uc001hvu.3_Missense_Mutation_p.E54Q	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	608					activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				AGATTGCAAAGAAAGGTACGT	0.348													C	233511808	C	C	233511808	3	2	137	1	0	0	0	0	1	0	0	0	8259	943	33	5	1848	5	KIAA1804	1	233511808	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	5111591	233511808	15738813	7	9396											
TARBP1	6894	broad.mit.edu	37	chr1	234541656	234541656	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagggctccttaccctgctcCgtgcatgctttccacttgat	9	14	0	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr1:234541656C>T	uc001hwd.2	-	24	3982	c.3982G>A	c.(3982-3984)GGA>AGA	p.G1328R		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	1328					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			TACCCTGCTCCGTGCATGCTT	0.532													T	234541656	T	T	234541656	3	4	137	1	0	0	0	0	1	0	0	0	15552	661	23	2	911	2	TARBP1	1	234541656	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	1029848	234541656	14708965	8	9397											
ABCB11	8647	broad.mit.edu	37	chr2	169783711	169783711	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgcagctgagcctgttttgcAgctgctatgactctttccat	9	11	1	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr2:169783711A>T	uc002ueo.1	-	26	3699	c.3573T>A	c.(3571-3573)GCT>GCA	p.A1191A	ABCB11_uc010zda.1_Silent_p.A609A|ABCB11_uc010zdb.1_Silent_p.A667A	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1191	Cytoplasmic (Potential).|ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CCTGTTTTGCAGCTGCTATGA	0.453													T	169783711	T	T	169783711	2	4	137	1	0	0	0	0	0	0	0	1	42	175	7	5		5	ABCB11	2	169783711	Silent	SNP	A	TCGA-14-1395-01B-11D-1845-08		169783711	73415662	9	9398											
MFSD6	54842	broad.mit.edu	37	chr2	191301881	191301881	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agatcgtcttcatcgtcttcGgcgttctcatgaccatggcc	9	13	4	2	rs147647208		TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr2:191301881G>T	uc002urz.2	+	3	1450	c.1126G>T	c.(1126-1128)GGC>TGC	p.G376C		NM_017694	NP_060164	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing	376	Helical; (Potential).				transmembrane transport	integral to membrane				ovary(2)	2						CATCGTCTTCGGCGTTCTCAT	0.517													T	191301881	T	T	191301881	3	4	137	1	0	0	0	0	1	0	0	0	9535	1116	39	5	1128	5	MFSD6	2	191301881	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	21518170	191301881	51897492	10	9399											
DNPEP	23549	broad.mit.edu	37	chr2	220246112	220246112	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatcagggcctctgacaccGcgtttgaagcatagcgttgc	13	11	2	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr2:220246112G>A	uc010zlg.1	-	13	1290	c.1208C>T	c.(1207-1209)GCG>GTG	p.A403V	DNPEP_uc010zlf.1_RNA|DNPEP_uc002vle.2_Missense_Mutation_p.A395V|DNPEP_uc002vlf.1_Missense_Mutation_p.A381V|DNPEP_uc002vlh.2_Missense_Mutation_p.A342V|DNPEP_uc002vli.1_Missense_Mutation_p.A342V	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	385					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	CTCTGACACCGCGTTTGAAGC	0.597													A	220246112	A	A	220246112	3	1	137	1	0	0	0	0	1	0	0	0	4679	1087	38	1	285	1	DNPEP	2	220246112	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	28944231	220246112	22953261	11	9400											
AGXT	189	broad.mit.edu	37	chr2	241808652	241808652	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aggaacccactcacactggtCatctctggctcgggacactg	10	14	3	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr2:241808652C>T	uc002waa.3	+	2	352	c.231C>T	c.(229-231)GTC>GTT	p.V77V	AGXT_uc010zoi.1_Silent_p.V77V	NM_000030	NP_000021	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	77					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity				0		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TCACACTGGTCATCTCTGGCT	0.607													T	241808652	T	T	241808652	2	4	137	1	0	0	0	0	0	0	0	1	404	813	29	3		3	AGXT	2	241808652	Silent	SNP	C	TCGA-14-1395-01B-11D-1845-08	21562540	241808652	1390721	12	9401											
CNTN6	27255	broad.mit.edu	37	chr3	1415706	1415706	+	Frame_Shift_Del	DEL	G	-	-													ttgttgccggcaacagcattGggattggagaaccaagtgaa							TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr3:1415706delG	uc003boz.2	+	16	2311	c.2044delG	c.(2044-2046)GGGfs	p.G682fs	CNTN6_uc011asj.1_Frame_Shift_Del_p.G610fs|CNTN6_uc003bpa.2_Frame_Shift_Del_p.G682fs	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	682	Fibronectin type-III 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CAACAGCATTGGGATTGGAGA	0.393													-	1415706	-	-	1415706	7	5	137	1	0	1	0	1	0	0	0	0	3645	1348	47	0	2102	0	CNTN6	3	1415706	Frame_Shift_Del	DEL	G	TCGA-14-1395-01B-11D-1845-08		1415706	196606724	13	9402											
SLC9A10	285335	broad.mit.edu	37	chr3	111918295	111918295	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacagtgacagcaatttctGggtgatcatactctaagtag	9	8	4	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr3:111918295G>A	uc003dyu.2	-	20	2618	c.2396C>T	c.(2395-2397)CCA>CTA	p.P799L	SLC9A10_uc011bhu.1_Missense_Mutation_p.P62L|SLC9A10_uc010hqc.2_Missense_Mutation_p.P751L	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	799					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						AGCAATTTCTGGGTGATCATA	0.279													A	111918295	A	A	111918295	3	1	137	1	0	0	0	0	1	0	0	0	14710	1348	47	3	1177	3	SLC9A10	3	111918295	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	110502589	111918295	86104135	14	9403											
LRRC31	79782	broad.mit.edu	37	chr3	169557943	169557943	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaaccattgtccacaatctcGaaaatttgatggtcgaaggc	8	9	1	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr3:169557943G>A	uc003fgc.1	-	9	1563	c.1486C>T	c.(1486-1488)CGA>TGA	p.R496*	LRRC31_uc010hwp.1_Nonsense_Mutation_p.R440*	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	496										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			CCACAATCTCGAAAATTTGAT	0.453													A	169557943	A	A	169557943	4	1	137	1	0	0	0	0	0	1	0	0	8986	1066	37	2	176	2	LRRC31	3	169557943	Nonsense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	57639648	169557943	28464487	15	9404											
CPN2	1370	broad.mit.edu	37	chr3	194061799	194061799	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtatgcgctgctactaggGccctgctgcccgagcctcga	12	15	0	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr3:194061799G>A	uc003fts.2	-	2	1723	c.1633C>T	c.(1633-1635)CCC>TCC	p.P545S		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	545					protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		TGCTACTAGGGCCCTGCTGCC	0.652													A	194061799	A	A	194061799	3	1	137	1	0	0	0	0	1	0	0	0	3810	1203	42	3	8	3	CPN2	3	194061799	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	24503856	194061799	3960631	16	9405											
ZNF732	654254	broad.mit.edu	37	chr4	265913	265913	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttgtaagatttctctccagTatgaactttatgtttagcaa	6	6	1	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr4:265913T>G	uc011buu.1	-	3	744	c.730A>C	c.(730-732)ACT>CCT	p.T244P	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCTCTCCAGTATGAACTTTA	0.363													G	265913	G	G	265913	3	3	137	1	0	0	0	0	1	0	0	0	18120	1638	57	5	1028	5	ZNF732	4	265913	Missense_Mutation	SNP	T	TCGA-14-1395-01B-11D-1845-08		265913	190888363	17	9406											
ZNF732	654254	broad.mit.edu	37	chr4	265995	265995	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtgaagggtttctctccagtAtgaattatctcatattcatt	7	7	3	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr4:265995A>T	uc011buu.1	-	3	662	c.648T>A	c.(646-648)CAT>CAA	p.H216Q	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	217	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCTCTCCAGTATGAATTATCT	0.348													T	265995	T	T	265995	3	4	137	1	0	0	0	0	1	0	0	0	18120	446	16	5	1110	5	ZNF732	4	265995	Missense_Mutation	SNP	A	TCGA-14-1395-01B-11D-1845-08	82	265995	190888281	18	9407											
UGT2B4	7363	broad.mit.edu	37	chr4	70351001	70351001	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtggaagtccaaactaacaGctgctcccttggccttcatg	9	12	1	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr4:70351001G>A	uc003hek.3	-	5	1282	c.1235C>T	c.(1234-1236)GCT>GTT	p.A412V	UGT2B4_uc011cap.1_Missense_Mutation_p.A276V|UGT2B4_uc003hel.3_Intron	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	412					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CAAACTAACAGCTGCTCCCTT	0.423													A	70351001	A	A	70351001	3	1	137	1	0	0	0	0	1	0	0	0	16958	971	34	3	359	3	UGT2B4	4	70351001	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	70085006	70351001	120803275	19	9408											
SULT1B1	27284	broad.mit.edu	37	chr4	70620981	70620981	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taatagattgacagttgttcTggagaaatatagagaataaa	9	2	1	4			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr4:70620981T>C	uc003hen.2	-	2	255	c.-43_splice	c.e2-1			NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member						3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						ACAGTTGTTCTGGAGAAATAT	0.328													C	70620981	C	C	70620981	5	2	137	1	0	0	0	0	0	0	1	0	15373	1594	55	4		4	SULT1B1	4	70620981	Splice_Site	SNP	T	TCGA-14-1395-01B-11D-1845-08	269980	70620981	120533295	20	9409											
C4orf32	132720	broad.mit.edu	37	chr4	113107978	113107978	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaggatgtattttggagaaCgaatagtggaaccagtaata	11	4	0	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr4:113107978C>T	uc003iah.2	+	2	467	c.283C>T	c.(283-285)CGA>TGA	p.R95*	C4orf32_uc003iai.2_RNA	NM_152400	NP_689613	Q8N8J7	CD032_HUMAN	chromosome 4 open reading frame 32	95						integral to membrane					0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00198)		TTTTGGAGAACGAATAGTGGA	0.413													T	113107978	T	T	113107978	4	4	137	1	0	0	0	0	0	1	0	0	2262	528	19	1	289	1	C4orf32	4	113107978	Nonsense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	42486997	113107978	78046298	21	9410											
CEP72	55722	broad.mit.edu	37	chr5	637858	637858	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacagctcagaaagcaggaaCgggaggaccttgtctcagcc	13	11	2	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr5:637858C>T	uc003jbf.2	+	7	1203	c.1131C>T	c.(1129-1131)AAC>AAT	p.N377N	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	377					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			AAAGCAGGAACGGGAGGACCT	0.622													T	637858	T	T	637858	2	4	137	1	0	0	0	0	0	0	0	1	3260	535	19	1		1	CEP72	5	637858	Silent	SNP	C	TCGA-14-1395-01B-11D-1845-08		637858	180277402	22	9411											
CDH18	1016	broad.mit.edu	37	chr5	19721516	19721516	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgctgtaaaccacccgagCgctgtttccataggtagggt	11	10	0	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr5:19721516C>T	uc003jgc.2	-	4	960	c.583G>A	c.(583-585)GCT>ACT	p.A195T	CDH18_uc003jgd.2_Missense_Mutation_p.A195T|CDH18_uc011cnm.1_Missense_Mutation_p.A195T	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	195	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A195T(1)		ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ACCACCCGAGCGCTGTTTCCA	0.463													T	19721516	T	T	19721516	3	4	137	1	0	0	0	0	1	0	0	0	3103	768	27	1	1825	1	CDH18	5	19721516	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	19083658	19721516	161193744	23	9412											
PCDHB16	57717	broad.mit.edu	37	chr5	140564331	140564331	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgatgcctgagggcccctttCcagggcgtctggtggacgta	15	12	1	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr5:140564331C>T	uc003liv.2	+	1	3352	c.2197C>T	c.(2197-2199)CCA>TCA	p.P733S	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	733	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCCCCTTTCCAGGGCGTCT	0.627													T	140564331	T	T	140564331	3	4	137	1	0	0	0	0	1	0	0	0	11541	855	30	3	2199	3	PCDHB16	5	140564331	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	120842815	140564331	40350929	24	9413											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056384	26056385	+	Frame_Shift_Ins	INS	-	C	C													ctttcgtttgcaccagagtgINScccttgctcaccaggctctt							TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr6:26056384_26056385insC	uc003nfw.2	-	1	315_316	c.272_273insG	c.(271-273)GGCfs	p.G91fs		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	91	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GCACCAGAGTGCCCTTGCTCAC	0.545													C	26056385	C	C	26056384	7	5	137	1	0	1	1	0	0	0	0	0	7124	1306	46	0	372	0	HIST1H1C	6	26056384	Frame_Shift_Ins	INS	-	TCGA-14-1395-01B-11D-1845-08		26056384	145058683	25	9414											
GABRR2	2570	broad.mit.edu	37	chr6	89975454	89975454	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagatgtggcgacgcaacGtgaagttaatgtacagacgg	14	6	0	4			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr6:89975454G>A	uc003pnb.2	-	7	850	c.842C>T	c.(841-843)ACG>ATG	p.T281M	GABRR2_uc011dzx.1_Missense_Mutation_p.T157M	NM_002043	NP_002034	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 2	281	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		GCGACGCAACGTGAAGTTAAT	0.517													A	89975454	A	A	89975454	3	1	137	1	0	0	0	0	1	0	0	0	6177	1145	40	1	642	1	GABRR2	6	89975454	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	63919070	89975454	81139613	26	9415											
ZBTB2	57621	broad.mit.edu	37	chr6	151687420	151687420	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccggagagtgaagcgccGtccacacaggtggcaggcat	15	12	0	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr6:151687420G>A	uc003qoh.2	-	3	916	c.781C>T	c.(781-783)CGG>TGG	p.R261W		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	261	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		GTGAAGCGCCGTCCACACAGG	0.557													A	151687420	A	A	151687420	3	1	137	1	0	0	0	0	1	0	0	0	17525	1144	40	1	767	1	ZBTB2	6	151687420	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	61711966	151687420	19427647	27	9416											
EGFR	1956	broad.mit.edu	37	chr7	55220295	55220295	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gctgccgtggcaagtcccccAgtgactgctgccacaaccag	11	16	0	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr7:55220295A>T	uc003tqk.2	+	6	931	c.685A>T	c.(685-687)AGT>TGT	p.S229C	EGFR_uc003tqh.2_Missense_Mutation_p.S229C|EGFR_uc003tqi.2_Missense_Mutation_p.S229C|EGFR_uc003tqj.2_Missense_Mutation_p.S229C|EGFR_uc010kzg.1_Missense_Mutation_p.S184C|EGFR_uc011kco.1_Missense_Mutation_p.S176C|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	229	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAAGTCCCCCAGTGACTGCTG	0.617		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55220295	T	T	55220295	3	4	137	1	0	0	0	0	1	0	0	0	4967	188	7	5	707	5	EGFR	7	55220295	Missense_Mutation	SNP	A	TCGA-14-1395-01B-11D-1845-08		55220295	103918368	28	9417											
MUC17	140453	broad.mit.edu	37	chr7	100677499	100677499	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtatgcctgacagcaccacGccggtagtcagttctgaggc	12	12	2	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr7:100677499G>A	uc003uxp.1	+	3	2855	c.2802G>A	c.(2800-2802)ACG>ACA	p.T934T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	934	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|13.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAGCACCACGCCGGTAGTCA	0.512													A	100677499	A	A	100677499	2	1	137	1	0	0	0	0	0	0	0	1	9974	1074	38	1		1	MUC17	7	100677499	Silent	SNP	G	TCGA-14-1395-01B-11D-1845-08	45457204	100677499	58461164	29	9418											
OR2F1	26211	broad.mit.edu	37	chr7	143657328	143657328	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggcacattttcttgcagaaCataaagccatcccattccag	6	12	1	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr7:143657328C>A	uc003wds.1	+	1	309	c.265C>A	c.(265-267)CAT>AAT	p.H89N		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					TCTTGCAGAACATAAAGCCAT	0.512													A	143657328	A	A	143657328	3	1	137	1	0	0	0	0	1	0	0	0	10996	478	17	5	267	5	OR2F1	7	143657328	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	42979829	143657328	15481335	30	9419											
EZH2	2146	broad.mit.edu	37	chr7	148512600	148512600	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaatggaaagatgctaacccTttttcagctgtatctttctg	8	8	3	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr7:148512600T>C	uc003wfd.1	-	13	1695	c.1529A>G	c.(1528-1530)AAG>AGG	p.K510R	EZH2_uc011kug.1_Missense_Mutation_p.K501R|EZH2_uc003wfb.1_Missense_Mutation_p.K515R|EZH2_uc003wfc.1_Missense_Mutation_p.K471R|EZH2_uc011kuh.1_Missense_Mutation_p.K501R	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	510					negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			ATGCTAACCCTTTTTCAGCTG	0.368			Mis		DLBCL								C	148512600	C	C	148512600	3	2	137	1	0	0	0	0	1	0	0	0	5334	1609	56	4	743	4	EZH2	7	148512600	Missense_Mutation	SNP	T	TCGA-14-1395-01B-11D-1845-08	4855272	148512600	10626063	31	9420											
NCOA2	10499	broad.mit.edu	37	chr8	71068332	71068338	+	Frame_Shift_Del	DEL	ATCTTTA	-	-													gttatttctggtaaaccaatAtctttagtatcatctttatc							TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr8:71068332_71068338delATCTTTA	uc003xyn.1	-	11	2424_2430	c.2262_2268delTAAAGAT	c.(2260-2268)ACTAAAGATfs	p.T754fs		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	754_756					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GTAAACCAATATCTTTAGTATCATCTT	0.411			T	RUNXBP2	AML								-	71068338	-	-	71068332	7	5	137	1	0	1	0	1	0	0	0	0	10229	446	16	0	2178	0	NCOA2	8	71068332	Frame_Shift_Del	DEL	ATCTTTA	TCGA-14-1395-01B-11D-1845-08		71068332	75295690	32	9421											
FAM75A6	389730	broad.mit.edu	37	chr9	43630642	43630642	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaacacccatggtgtggaGctgggggcgtttagcgatga	15	9	0	1	rs2808959		TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr9:43630642G>A	uc011lrb.1	-	1	89	c.60C>T	c.(58-60)AGC>AGT	p.S20S		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	20						integral to membrane					0						ATGGTGTGGAGCTGGGGGCGT	0.473													A	43630642	A	A	43630642	2	1	137	1	0	0	0	0	0	0	0	1	5622	962	34	3		3	FAM75A6	9	43630642	Silent	SNP	G	TCGA-14-1395-01B-11D-1845-08		43630642	97582789	33	9422											
COL5A1	1289	broad.mit.edu	37	chr9	137676834	137676834	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcctcttttctggcttgcaGggggagatcggcccacccgg	13	14	2	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr9:137676834G>T	uc004cfe.2	+	30	2867	c.2485_splice	c.e30-1	p.G829_splice		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein						axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTGGCTTGCAGGGGGAGATCG	0.632													T	137676834	T	T	137676834	5	4	137	1	0	0	0	0	0	0	1	0	3696	1014	35	5	2602	5	COL5A1	9	137676834	Splice_Site	SNP	G	TCGA-14-1395-01B-11D-1845-08	94046192	137676834	3536597	34	9423											
CUBN	8029	broad.mit.edu	37	chr10	16994307	16994307	+	Frame_Shift_Del	DEL	T	-	-													cttgaatgatccagctgcagTtctgattgtttggataattg							TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr10:16994307delT	uc001ioo.2	-	33	4989	c.4937delA	c.(4936-4938)AACfs	p.N1646fs		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1646	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCAGCTGCAGTTCTGATTGTT	0.478													-	16994307	-	-	16994307	7	5	137	1	0	1	0	1	0	0	0	0	4051	1725	60	0	6074	0	CUBN	10	16994307	Frame_Shift_Del	DEL	T	TCGA-14-1395-01B-11D-1845-08		16994307	118540440	35	9424											
PTEN	5728	broad.mit.edu	37	chr10	89711928	89711928	+	Frame_Shift_Del	DEL	A	-	-													tattattatagctacctgttAaagaatcatctggattatag							TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr10:89711928delA	uc001kfb.2	+	7	1577	c.546delA	c.(544-546)TTAfs	p.L182fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	182	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.L182fs*16(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G165_K342del(1)|p.G165_*404del(1)|p.K183fs*7(1)|p.L182F(1)|p.V175fs*3(1)|p.L182*(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GCTACCTGTTAAAGAATCATC	0.388		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89711928	-	-	89711928	7	5	137	1	0	1	0	1	0	0	0	0	12738	359	13	0	568	0	PTEN	10	89711928	Frame_Shift_Del	DEL	A	TCGA-14-1395-01B-11D-1845-08	72717621	89711928	45822819	36	9425											
SORCS3	22986	broad.mit.edu	37	chr10	106960921	106960921	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggaaaatattcaagaaacGtaagccaggagctcagtgtg	11	6	2	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr10:106960921G>A	uc001kyi.1	+	16	2398	c.2171G>A	c.(2170-2172)CGT>CAT	p.R724H	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	724	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TTCAAGAAACGTAAGCCAGGA	0.468													A	106960921	A	A	106960921	3	1	137	1	0	0	0	0	1	0	0	0	14932	1145	40	1	2233	1	SORCS3	10	106960921	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	17248993	106960921	28573826	37	9426											
OR51G1	79324	broad.mit.edu	37	chr11	4944755	4944755	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acatgaagaggtgtacaacgCggggcagatgttcaccaaag	13	8	1	3	rs146006146	by1000genomes	TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr11:4944755C>T	uc010qyr.1	-	1	815	c.815G>A	c.(814-816)CGC>CAC	p.R272H		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTGTACAACGCGGGGCAGATG	0.502													T	4944755	T	T	4944755	3	4	137	1	0	0	0	0	1	0	0	0	11098	768	27	1	152	1	OR51G1	11	4944755	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08		4944755	130061761	38	9427											
LPXN	9404	broad.mit.edu	37	chr11	58338166	58338166	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtcctgaagggtggagcgttCcagttcctccaataaggcat	12	10	0	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr11:58338166C>T	uc001nmw.2	-	2	179	c.34G>A	c.(34-36)GAA>AAA	p.E12K	LPXN_uc009ymp.2_5'UTR|LPXN_uc010rkj.1_Missense_Mutation_p.E17K|LPXN_uc010rkk.1_Nonsense_Mutation_p.W7*	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	12	LD motif 1.				cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GTGGAGCGTTCCAGTTCCTCC	0.433													T	58338166	T	T	58338166	3	4	137	1	0	0	0	0	1	0	0	0	8929	864	30	3	1158	3	LPXN	11	58338166	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	53393411	58338166	76668350	39	9428											
DAGLA	747	broad.mit.edu	37	chr11	61511463	61511463	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagtgctgcggccaatgaCgaggaggaagaggttggcgg	18	9	0	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr11:61511463C>T	uc001nsa.2	+	20	2742	c.2631C>T	c.(2629-2631)GAC>GAT	p.D877D		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	877	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		CGGCCAATGACGAGGAGGAAG	0.726													T	61511463	T	T	61511463	2	4	137	1	0	0	0	0	0	0	0	1	4226	535	19	1		1	DAGLA	11	61511463	Silent	SNP	C	TCGA-14-1395-01B-11D-1845-08	3173297	61511463	73495053	40	9429											
TRIM49	57093	broad.mit.edu	37	chr11	89531775	89531775	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagatatcattgttggcttcTtcatgatgcagagtaatatg	9	5	3	3			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr11:89531775T>C	uc001pdb.2	-	8	1211	c.882A>G	c.(880-882)GAA>GAG	p.E294E		NM_020358	NP_065091	P0CI25	TRI49_HUMAN	ring finger protein 18	294	B30.2/SPRY.					intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TGTTGGCTTCTTCATGATGCA	0.313													C	89531775	C	C	89531775	2	2	137	1	0	0	0	0	0	0	0	1	16521	1606	56	4		4	TRIM49	11	89531775	Silent	SNP	T	TCGA-14-1395-01B-11D-1845-08	28020312	89531775	45474741	41	9430											
BARX2	8538	broad.mit.edu	37	chr11	129306839	129306839	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagagacggaacagcccacGccccgacagaagaagccccg	11	16	1	3			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr11:129306839G>A	uc001qfc.3	+	2	431	c.381G>A	c.(379-381)ACG>ACA	p.T127T		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	BarH-like homeobox 2	127											0	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		AACAGCCCACGCCCCGACAGA	0.637													A	129306839	A	A	129306839	2	1	137	1	0	0	0	0	0	0	0	1	1316	1074	38	1		1	BARX2	11	129306839	Silent	SNP	G	TCGA-14-1395-01B-11D-1845-08	39775064	129306839	5699677	42	9431											
SLC38A4	55089	broad.mit.edu	37	chr12	47186771	47186771	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttttctgaatttcctatcccGatgtagctatctggagcact	7	10	2	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr12:47186771G>A	uc001rpi.2	-	3	483	c.84C>T	c.(82-84)ATC>ATT	p.I28I	SLC38A4_uc001rpj.2_Silent_p.I28I|SLC38A4_uc009zkl.2_Silent_p.I28I	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	28	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					TTCCTATCCCGATGTAGCTAT	0.438													A	47186771	A	A	47186771	2	1	137	1	0	0	0	0	0	0	0	1	14606	1048	37	2		2	SLC38A4	12	47186771	Silent	SNP	G	TCGA-14-1395-01B-11D-1845-08		47186771	86665124	43	9432											
TRHDE	29953	broad.mit.edu	37	chr12	73046870	73046870	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtcataatccatgtagctcGaaatccacatggtcgagacc	8	11	1	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr12:73046870G>A	uc001sxa.2	+	17	2813	c.2783G>A	c.(2782-2784)CGA>CAA	p.R928Q		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	928	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CATGTAGCTCGAAATCCACAT	0.353													A	73046870	A	A	73046870	3	1	137	1	0	0	0	0	1	0	0	0	16476	1058	37	2	2849	2	TRHDE	12	73046870	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	25860099	73046870	60805025	44	9433											
SLC5A8	160728	broad.mit.edu	37	chr12	101588904	101588904	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaatgtgcagaccacccccGttgccactaccgcgccccac	8	19	0	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr12:101588904G>A	uc001thz.3	-	4	896	c.506C>T	c.(505-507)ACG>ATG	p.T169M		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	169	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						GACCACCCCCGTTGCCACTAC	0.398													A	101588904	A	A	101588904	3	1	137	1	0	0	0	0	1	0	0	0	14671	1145	40	1	1374	1	SLC5A8	12	101588904	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	28542034	101588904	32262991	45	9434											
TMEM132D	121256	broad.mit.edu	37	chr12	130185158	130185158	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaagaaggagacgtccgcGttgttgatgtggtaggtcac	16	6	1	3			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr12:130185158G>A	uc009zyl.1	-	2	493	c.165C>T	c.(163-165)AAC>AAT	p.N55N		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	55	Extracellular (Potential).					integral to membrane		p.N55T(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGACGTCCGCGTTGTTGATGT	0.547													A	130185158	A	A	130185158	2	1	137	1	0	0	0	0	0	0	0	1	16044	1136	40	1		1	TMEM132D	12	130185158	Silent	SNP	G	TCGA-14-1395-01B-11D-1845-08	28596254	130185158	3666737	46	9435											
MTUS2	23281	broad.mit.edu	37	chr13	29599206	29599206	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacagatagcctgcagaccaCgcggagtattcagggaccaa	11	12	1	2			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr13:29599206C>T	uc001usl.3	+	1	459	c.401C>T	c.(400-402)ACG>ATG	p.T134M		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	124						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						CTGCAGACCACGCGGAGTATT	0.502													T	29599206	T	T	29599206	3	4	137	1	0	0	0	0	1	0	0	0	9966	536	19	1	403	1	MTUS2	13	29599206	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08		29599206	85570672	47	9436											
KIF26A	26153	broad.mit.edu	37	chr14	104641823	104641823	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgatggctgccagcacccctCgaggcagttctggtccagac	12	15	1	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr14:104641823C>T	uc001yos.3	+	12	2698	c.2698C>T	c.(2698-2700)CGA>TGA	p.R900*		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	900					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CAGCACCCCTCGAGGCAGTTC	0.692													T	104641823	T	T	104641823	4	4	137	1	0	0	0	0	0	1	0	0	8294	876	31	2	2744	2	KIF26A	14	104641823	Nonsense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08		104641823	2707717	48	9437											
CA12	771	broad.mit.edu	37	chr15	63618489	63618489	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagctccggggacctcaagCgtgggcctcagtctccatct	13	14	4	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr15:63618489C>T	uc002amc.2	-	11	1216	c.1060G>A	c.(1060-1062)GCT>ACT	p.A354T	CA12_uc002amd.2_Missense_Mutation_p.A343T|CA12_uc002ame.2_Missense_Mutation_p.A283T	NM_001218	NP_001209	O43570	CAH12_HUMAN	carbonic anhydrase XII isoform 1 precursor	354	Cytoplasmic (Potential).				one-carbon metabolic process	integral to membrane	carbonate dehydratase activity|zinc ion binding			ovary(1)	1					Acetazolamide(DB00819)	GGACCTCAAGCGTGGGCCTCA	0.507													T	63618489	T	T	63618489	3	4	137	1	0	0	0	0	1	0	0	0	2513	768	27	1	8	1	CA12	15	63618489	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08		63618489	38912903	49	9438											
GOLGA6B	55889	broad.mit.edu	37	chr15	72954612	72954612	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctaagcccccatccctggcGcccccagcagtgacctctgt	9	19	1	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr15:72954612G>A	uc010uks.1	+	11	908	c.867G>A	c.(865-867)GCG>GCA	p.A289A		NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	289	Potential.										0						CATCCCTGGCGCCCCCAGCAG	0.537													A	72954612	A	A	72954612	2	1	137	1	0	0	0	0	0	0	0	1	6558	1074	38	1		1	GOLGA6B	15	72954612	Silent	SNP	G	TCGA-14-1395-01B-11D-1845-08	9336123	72954612	29576780	50	9439											
C16orf61	56942	broad.mit.edu	37	chr16	81015432	81015432	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcattcttcaggcattttctCaactcccgatcaacatcatt	3	13	6	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr16:81015432C>T	uc002ffu.2	-	3	331	c.132G>A	c.(130-132)TTG>TTA	p.L44L	C16orf61_uc002ffv.2_Intron	NM_020188	NP_064573	Q9NRP2	CP061_HUMAN	hypothetical protein LOC56942	44											0						GGCATTTTCTCAACTCCCGAT	0.323													T	81015432	T	T	81015432	2	4	137	1	0	0	0	0	0	0	0	1	1824	825	29	3		3	C16orf61	16	81015432	Silent	SNP	C	TCGA-14-1395-01B-11D-1845-08		81015432	9339321	51	9440											
AURKB	9212	broad.mit.edu	37	chr17	8108652	8108652	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccttctcattgtgcatgCgcccctcaatcatctctggg	7	16	4	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr17:8108652C>T	uc002gkm.2	-	8	804	c.743G>A	c.(742-744)CGC>CAC	p.R248H	AURKB_uc010cnu.2_Missense_Mutation_p.R68H|AURKB_uc002gkn.2_Missense_Mutation_p.R249H|AURKB_uc010vuu.1_Missense_Mutation_p.R207H|AURKB_uc002gko.2_RNA	NM_004217	NP_004208	Q96GD4	AURKB_HUMAN	aurora kinase B	248	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic prometaphase|protein localization to kinetochore	chromosome passenger complex|condensed nuclear chromosome, centromeric region|cytosol|spindle	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(1)|central_nervous_system(1)	4						ATTGTGCATGCGCCCCTCAAT	0.572													T	8108652	T	T	8108652	3	4	137	1	0	0	0	0	1	0	0	0	1223	768	27	1	299	1	AURKB	17	8108652	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08		8108652	73086558	52	9441											
KRT20	54474	broad.mit.edu	37	chr17	39041110	39041110	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgcgaccagccctcggggCgttggtttcgtaccactgct	13	14	0	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr17:39041110C>T	uc002hvl.2	-	1	370	c.328G>A	c.(328-330)GCC>ACC	p.A110T		NM_019010	NP_061883	P35900	K1C20_HUMAN	keratin 20	110	Rod.|Linker 1.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			large_intestine(1)|kidney(1)|skin(1)	3		Breast(137;0.000301)|Ovarian(249;0.15)				GCCCTCGGGGCGTTGGTTTCG	0.498													T	39041110	T	T	39041110	3	4	137	1	0	0	0	0	1	0	0	0	8458	768	27	1	978	1	KRT20	17	39041110	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	30932458	39041110	42154100	53	9442											
PLEKHH3	79990	broad.mit.edu	37	chr17	40823101	40823101	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctcgtacagcgcgaatgcGttgcggctccgggccaagcc	14	14	0	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr17:40823101G>A	uc002iau.2	-	9	1799	c.1332C>T	c.(1330-1332)AAC>AAT	p.N444N	PLEKHH3_uc010cyl.1_Intron|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Intron|PLEKHH3_uc002iaw.2_Silent_p.N444N	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	444	FERM.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GCGCGAATGCGTTGCGGCTCC	0.657													A	40823101	A	A	40823101	2	1	137	1	0	0	0	0	0	0	0	1	12078	1136	40	1		1	PLEKHH3	17	40823101	Silent	SNP	G	TCGA-14-1395-01B-11D-1845-08	1781991	40823101	40372109	54	9443											
ST8SIA5	29906	broad.mit.edu	37	chr18	44260326	44260326	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtagtagacagcttgcggCgattcgaagtcgtccagcac	12	10	0	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr18:44260326C>T	uc002lcj.1	-	7	1378	c.810G>A	c.(808-810)TCG>TCA	p.S270S	ST8SIA5_uc002lci.1_Silent_p.S117S|ST8SIA5_uc010xcy.1_Silent_p.S306S|ST8SIA5_uc010xcz.1_Silent_p.S239S	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	270	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						CAGCTTGCGGCGATTCGAAGT	0.617													T	44260326	T	T	44260326	2	4	137	1	0	0	0	0	0	0	0	1	15234	755	27	1		1	ST8SIA5	18	44260326	Silent	SNP	C	TCGA-14-1395-01B-11D-1845-08		44260326	33816922	55	9444											
HOOK2	29911	broad.mit.edu	37	chr19	12874555	12874555	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagttctggaggtgcccccGcagctggccgctgcttgggt	17	12	1	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr19:12874555G>A	uc002muy.2	-	21	2036	c.1865C>T	c.(1864-1866)GCG>GTG	p.A622V	HOOK2_uc010xmq.1_Missense_Mutation_p.A27V|HOOK2_uc002muz.2_Missense_Mutation_p.A620V	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	622	Sufficient for interaction with CEP110.|Required for localization to the centrosome and induction of aggresome formation.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						AGGTGCCCCCGCAGCTGGCCG	0.602													A	12874555	A	A	12874555	3	1	137	1	0	0	0	0	1	0	0	0	7283	1087	38	1	306	1	HOOK2	19	12874555	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08		12874555	46254428	56	9445											
MAST3	23031	broad.mit.edu	37	chr19	18255858	18255858	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gagccccctttccccgcgctCtctgtcctcgaacccgtcgt	8	20	1	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr19:18255858C>G	uc002nhz.3	+	23	2771	c.2771C>G	c.(2770-2772)TCT>TGT	p.S924C		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	924	Ser-rich.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						TCCCCGCGCTCTCTGTCCTCG	0.682													G	18255858	G	G	18255858	3	3	137	1	0	0	0	0	1	0	0	0	9326	913	32	5	2861	5	MAST3	19	18255858	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	5381303	18255858	40873125	57	9446											
ZNF569	148266	broad.mit.edu	37	chr19	37903536	37903536	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctggtgtctaacaaggtgcGacttttggctgaaagccttg	12	8	2	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr19:37903536G>A	uc002ogi.2	-	6	2582	c.2024C>T	c.(2023-2025)TCG>TTG	p.S675L	ZNF569_uc002ogh.2_Missense_Mutation_p.S516L|ZNF569_uc002ogj.2_Missense_Mutation_p.S699L	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	675	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AACAAGGTGCGACTTTTGGCT	0.413													A	37903536	A	A	37903536	3	1	137	1	0	0	0	0	1	0	0	0	17997	1059	37	2	40	2	ZNF569	19	37903536	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	19647678	37903536	21225447	58	9447											
MED29	55588	broad.mit.edu	37	chr19	39883120	39883120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctagaccttgatgaaggttgCggcccaaaacttgattcaga	10	9	1	5			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr19:39883120C>T	uc002olf.2	+	2	333	c.296C>T	c.(295-297)GCG>GTG	p.A99V	PAF1_uc002old.2_5'Flank|PAF1_uc002ole.1_5'Flank|PAF1_uc010xuv.1_5'Flank|MED29_uc010xuw.1_Missense_Mutation_p.A99V|MED29_uc010xux.1_Intron	NM_017592	NP_060062	Q9NX70	MED29_HUMAN	mediator complex subunit 29	78	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding			ovary(1)|pancreas(1)	2	all_cancers(60;7.82e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;1.04e-26)|all cancers(26;7.68e-24)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			ATGAAGGTTGCGGCCCAAAAC	0.418													T	39883120	T	T	39883120	3	4	137	1	0	0	0	0	1	0	0	0	9447	768	27	1	302	1	MED29	19	39883120	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	1979584	39883120	19245863	59	9448											
ZNF229	7772	broad.mit.edu	37	chr19	44932748	44932748	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcatctgtatggcttctcGccagtgtgcactctcttatg	10	11	3	0			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr19:44932748G>A	uc002oze.1	-	6	2642	c.2208C>T	c.(2206-2208)GGC>GGT	p.G736G	ZNF229_uc010ejk.1_Silent_p.G390G|ZNF229_uc010ejl.1_Silent_p.G730G	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	736					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				ATGGCTTCTCGCCAGTGTGCA	0.488													A	44932748	A	A	44932748	2	1	137	1	0	0	0	0	0	0	0	1	17779	1074	38	1		1	ZNF229	19	44932748	Silent	SNP	G	TCGA-14-1395-01B-11D-1845-08	5049628	44932748	14196235	60	9449											
GRIN2D	2906	broad.mit.edu	37	chr19	48919313	48919313	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctcaccatcaacgaggagCgctccgagatcgtggacttc	10	15	2	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr19:48919313C>T	uc002pjc.3	+	7	1724	c.1636C>T	c.(1636-1638)CGC>TGC	p.R546C		NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	546	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CAACGAGGAGCGCTCCGAGAT	0.672													T	48919313	T	T	48919313	3	4	137	1	0	0	0	0	1	0	0	0	6782	768	27	1	1658	1	GRIN2D	19	48919313	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	3986565	48919313	10209670	61	9450											
ZNF320	162967	broad.mit.edu	37	chr19	53384360	53384360	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctttcaagatgtgatttgCgactgaaaactttgtcgcat	9	7	2	3			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr19:53384360C>T	uc002qag.2	-	4	1210	c.1019G>A	c.(1018-1020)CGC>CAC	p.R340H	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.R286H|ZNF320_uc002qai.2_Missense_Mutation_p.R340H	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	340	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		ATGTGATTTGCGACTGAAAAC	0.428													T	53384360	T	T	53384360	3	4	137	1	0	0	0	0	1	0	0	0	17836	768	27	1	514	1	ZNF320	19	53384360	Missense_Mutation	SNP	C	TCGA-14-1395-01B-11D-1845-08	4465047	53384360	5744623	62	9451											
ZNF677	342926	broad.mit.edu	37	chr19	53741592	53741592	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atgttgttgatcttttctgtGagtgagatttttgttacagg	11	3	2	3			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr19:53741592G>T	uc002qbf.1	-	5	573	c.388C>A	c.(388-390)CAC>AAC	p.H130N	ZNF677_uc002qbg.1_Missense_Mutation_p.H130N	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		TCTTTTCTGTGAGTGAGATTT	0.353													T	53741592	T	T	53741592	3	4	137	1	0	0	0	0	1	0	0	0	18081	1290	45	5	1370	5	ZNF677	19	53741592	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08	357232	53741592	5387391	63	9452											
TRPM2	7226	broad.mit.edu	37	chr21	45821664	45821664	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaacatcctctcctacttcGccttcctctgcctgttcgcc	5	18	2	1			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr21:45821664G>A	uc002zet.1	+	17	2635	c.2422G>A	c.(2422-2424)GCC>ACC	p.A808T	TRPM2_uc002zeu.1_Missense_Mutation_p.A808T|TRPM2_uc002zew.1_Missense_Mutation_p.A808T|TRPM2_uc010gpt.1_Missense_Mutation_p.A808T|TRPM2_uc002zex.1_Missense_Mutation_p.A594T|TRPM2_uc002zey.1_Missense_Mutation_p.A321T	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	808	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTCCTACTTCGCCTTCCTCTG	0.632													A	45821664	A	A	45821664	3	1	137	1	0	0	0	0	1	0	0	0	16583	1087	38	1	2484	1	TRPM2	21	45821664	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08		45821664	2308231	64	9453											
CABIN1	23523	broad.mit.edu	37	chr22	24483514	24483514	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttggaagcatgccacgcccGtcttgaactgcttccgtcgg	11	13	1	1	rs148592192		TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chr22:24483514G>A	uc002zzi.1	+	23	3500	c.3373G>A	c.(3373-3375)GTC>ATC	p.V1125I	CABIN1_uc002zzj.1_Missense_Mutation_p.V1075I|CABIN1_uc002zzl.1_Missense_Mutation_p.V1125I	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1125	TPR 6.				cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TGCCACGCCCGTCTTGAACTG	0.577													A	24483514	A	A	24483514	3	1	137	1	0	0	0	0	1	0	0	0	2528	1145	40	1	3459	1	CABIN1	22	24483514	Missense_Mutation	SNP	G	TCGA-14-1395-01B-11D-1845-08		24483514	26821052	65	9454											
MAGEC1	9947	broad.mit.edu	37	chrX	140994696	140994696	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagagttcccctgagtgtacTcaaagtacttttgagggttt	10	8	1	3			TCGA-14-1395-01B-11D-1845-08	TCGA-14-1395-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8825b7a5-dfac-4e21-b4ec-05161b1341e9	24b4b0b6-3f83-42d6-846b-e73b3baa0fc9	g.chrX:140994696T>A	uc004fbt.2	+	4	1792	c.1506T>A	c.(1504-1506)ACT>ACA	p.T502T	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	502							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTGAGTGTACTCAAAGTACTT	0.498										HNSCC(15;0.026)			A	140994696	A	A	140994696	2	1	137	1	0	0	0	0	0	0	0	1	9180	1538	54	5		5	MAGEC1	23	140994696	Silent	SNP	T	TCGA-14-1395-01B-11D-1845-08		140994696	14275864	66	9455											
C8A	731	broad.mit.edu	37	chr1	57333307	57333307	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taagacgggcagctacacccGcagcagttacctgccagctg	11	14	0	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr1:57333307G>A	uc001cyo.2	+	2	235	c.103G>A	c.(103-105)GCA>ACA	p.A35T		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	35					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AGCTACACCCGCAGCAGTTAC	0.448													A	57333307	A	A	57333307	3	1	138	1	0	0	0	0	1	0	0	0	2416	1087	38	1	109	1	C8A	1	57333307	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08		57333307	191917314	1	9456											
PRCC	5546	broad.mit.edu	37	chr1	156764463	156764463	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttttcttttccagtttaagCggctgcagggcaagaggaac	11	8	1	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr1:156764463C>T	uc001fqa.2	+	5	1476	c.1186C>T	c.(1186-1188)CGG>TGG	p.R396W	PRCC_uc001fqb.2_Missense_Mutation_p.R364W	NM_005973	NP_005964	Q92733	PRCC_HUMAN	papillary renal cell carcinoma	396					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	kidney(25)|central_nervous_system(2)	27	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCAGTTTAAGCGGCTGCAGGG	0.478			T	TFE3	papillary renal 								T	156764463	T	T	156764463	3	4	138	1	0	0	0	0	1	0	0	0	12447	759	27	1	1204	1	PRCC	1	156764463	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	99431156	156764463	92486158	2	9457											
CACNA1E	777	broad.mit.edu	37	chr1	181689358	181689358	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaggtattgggcttccctaCggaatttggtggtctccttg	13	8	1	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr1:181689358C>T	uc001gow.2	+	14	1933	c.1768C>T	c.(1768-1770)CGG>TGG	p.R590W	CACNA1E_uc009wxs.2_Missense_Mutation_p.R497W	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	590	Cytoplasmic (Potential).|II.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GGCTTCCCTACGGAATTTGGT	0.478													T	181689358	T	T	181689358	3	4	138	1	0	0	0	0	1	0	0	0	2542	527	19	1	1822	1	CACNA1E	1	181689358	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	24924895	181689358	67561263	3	9458											
PROX1	5629	broad.mit.edu	37	chr1	214170642	214170642	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acagctgcgccagctgcaggAaaagttctaccaaatctatg	9	11	2	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr1:214170642A>G	uc001hkh.2	+	2	1036	c.764A>G	c.(763-765)GAA>GGA	p.E255G	PROX1_uc001hkg.1_Missense_Mutation_p.E255G	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	255					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CAGCTGCAGGAAAAGTTCTAC	0.532													G	214170642	G	G	214170642	3	3	138	1	0	0	0	0	1	0	0	0	12560	246	9	4	766	4	PROX1	1	214170642	Missense_Mutation	SNP	A	TCGA-14-1450-01B-01D-1845-08	32481284	214170642	35079979	4	9459											
HEATR5B	54497	broad.mit.edu	37	chr2	37215846	37215846	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacttttattccttcttgaaCcgctaaaagctctatgttac	4	10	2	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr2:37215846C>T	uc002rpp.1	-	35	5950	c.5854G>A	c.(5854-5856)GTT>ATT	p.V1952I	HEATR5B_uc002rpo.1_Missense_Mutation_p.V264I|HEATR5B_uc010ezy.1_Missense_Mutation_p.V447I	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1952							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				CCTTCTTGAACCGCTAAAAGC	0.348													T	37215846	T	T	37215846	3	4	138	1	0	0	0	0	1	0	0	0	7032	507	18	3	369	3	HEATR5B	2	37215846	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08		37215846	205983527	5	9460											
RGPD4	285190	broad.mit.edu	37	chr2	108443529	108443529	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccgtgcagggctccgccccGtcgcctcgaaaggtgagtgg	15	14	0	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr2:108443529G>A	uc010ywk.1	+	1	142	c.60G>A	c.(58-60)CCG>CCA	p.P20P	LOC729121_uc010ywj.1_5'Flank|LOC729121_uc002tdt.2_5'Flank	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	20					intracellular transport		binding			skin(2)	2						GCTCCGCCCCGTCGCCTCGAA	0.711													A	108443529	A	A	108443529	2	1	138	1	0	0	0	0	0	0	0	1	13288	1132	40	1		1	RGPD4	2	108443529	Silent	SNP	G	TCGA-14-1450-01B-01D-1845-08	71227683	108443529	134755844	6	9461											
IL1RN	3557	broad.mit.edu	37	chr2	113890404	113890404	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcctcaccaatatgcctgacGaaggcgtcatggtcaccaaa	9	13	3	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr2:113890404G>A	uc002tjb.2	+	4	554	c.490G>A	c.(490-492)GAA>AAA	p.E164K	IL1RN_uc002tix.1_RNA|IL1RN_uc002tiy.2_Missense_Mutation_p.E130K|IL1RN_uc002tiz.2_Missense_Mutation_p.E167K|IL1RN_uc002tja.2_Missense_Mutation_p.E146K	NM_173842	NP_776214	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist isoform 1	164					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			skin(2)	2					Anakinra(DB00026)	TATGCCTGACGAAGGCGTCAT	0.592									Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				A	113890404	A	A	113890404	3	1	138	1	0	0	0	0	1	0	0	0	7665	1059	37	2	585	2	IL1RN	2	113890404	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	5446875	113890404	129308969	7	9462											
ALPPL2	251	broad.mit.edu	37	chr2	233274348	233274348	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagacccacgcaggcgaggaCgtggcggtgttcgcgcgcgg	19	12	0	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr2:233274348C>T	uc002vss.3	+	11	1418	c.1365C>T	c.(1363-1365)GAC>GAT	p.D455D		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	455					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CAGGCGAGGACGTGGCGGTGT	0.662													T	233274348	T	T	233274348	2	4	138	1	0	0	0	0	0	0	0	1	549	535	19	1		1	ALPPL2	2	233274348	Silent	SNP	C	TCGA-14-1450-01B-01D-1845-08	119383944	233274348	9925025	8	9463											
CSN3	1448	broad.mit.edu	37	chr4	71114964	71114964	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgtggtacgtcgcccaaacCtgcatccatcatttattgcc	7	14	1	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr4:71114964C>A	uc003hfe.3	+	4	395	c.337C>A	c.(337-339)CTG>ATG	p.L113M		NM_005212	NP_005203	P07498	CASK_HUMAN	casein kappa precursor	113						extracellular region	protein binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TCGCCCAAACCTGCATCCATC	0.468													A	71114964	A	A	71114964	3	1	138	1	0	0	0	0	1	0	0	0	3949	680	24	5	347	5	CSN3	4	71114964	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08		71114964	120039312	9	9464											
ANKRD17	26057	broad.mit.edu	37	chr4	73984505	73984505	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaccacatcgaggtgtccaCcatttgctgctagccacaat	8	13	0	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr4:73984505C>T	uc003hgp.2	-	22	4205	c.4088G>A	c.(4087-4089)GGT>GAT	p.G1363D	ANKRD17_uc003hgo.2_Missense_Mutation_p.G1250D|ANKRD17_uc003hgq.2_Missense_Mutation_p.G1112D|ANKRD17_uc003hgr.2_Missense_Mutation_p.G1362D|ANKRD17_uc011cbd.1_Missense_Mutation_p.G928D	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1363	ANK 24.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GAGGTGTCCACCATTTGCTGC	0.443													T	73984505	T	T	73984505	3	4	138	1	0	0	0	0	1	0	0	0	646	507	18	3	3775	3	ANKRD17	4	73984505	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	2869541	73984505	117169771	10	9465											
ADH1B	125	broad.mit.edu	37	chr4	100239237	100239237	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gtcaccccttctccaacactCtccacgatgccggctgcctc	6	20	3	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr4:100239237C>A	uc003hus.3	-	3	309	c.225G>T	c.(223-225)GAG>GAT	p.E75D	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Missense_Mutation_p.E35D|ADH1B_uc011ceh.1_5'UTR|ADH1B_uc011cei.1_Missense_Mutation_p.E35D	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	75					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	CTCCAACACTCTCCACGATGC	0.537													A	100239237	A	A	100239237	3	1	138	1	0	0	0	0	1	0	0	0	308	912	32	5	930	5	ADH1B	4	100239237	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	26254732	100239237	90915039	11	9466											
ADH1C	126	broad.mit.edu	37	chr4	100268197	100268197	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtcaccccttctcaaacactTtccacgatgccggctgcctc	6	18	2	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr4:100268197T>A	uc003huu.2	-	3	310	c.225A>T	c.(223-225)GAA>GAT	p.E75D		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	75					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	CTCAAACACTTTCCACGATGC	0.502									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				A	100268197	A	A	100268197	3	1	138	1	0	0	0	0	1	0	0	0	309	1838	64	5	930	5	ADH1C	4	100268197	Missense_Mutation	SNP	T	TCGA-14-1450-01B-01D-1845-08	28960	100268197	90886079	12	9467											
MMAA	166785	broad.mit.edu	37	chr4	146576356	146576356	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaatgtgggataaaatgAaagatttccaggacctaatg	10	5	0	3			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr4:146576356A>T	uc003ikh.3	+	7	1112	c.1027A>T	c.(1027-1029)AAA>TAA	p.K343*	MMAA_uc010iow.2_RNA	NM_172250	NP_758454	Q8IVH4	MMAA_HUMAN	methylmalonic aciduria type A precursor	343						mitochondrion	GTP binding|nucleoside-triphosphatase activity			ovary(1)	1	all_hematologic(180;0.151)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGATAAAATGAAAGATTTCCA	0.428													T	146576356	T	T	146576356	4	4	138	1	0	0	0	0	0	1	0	0	9639	247	9	5	1049	5	MMAA	4	146576356	Nonsense_Mutation	SNP	A	TCGA-14-1450-01B-01D-1845-08	46308159	146576356	44577920	13	9468											
CCDC110	256309	broad.mit.edu	37	chr4	186382220	186382220	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccaaatccttttcaatgcGcgtgccaaacaccagatttt	5	12	1	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr4:186382220G>A	uc003ixu.3	-	5	407	c.331C>T	c.(331-333)CGC>TGC	p.R111C	CCDC110_uc003ixv.3_Intron|CCDC110_uc011ckt.1_Missense_Mutation_p.R111C	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	111						nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTTTCAATGCGCGTGCCAAAC	0.338													A	186382220	A	A	186382220	3	1	138	1	0	0	0	0	1	0	0	0	2747	1087	38	1	2182	1	CCDC110	4	186382220	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	39805864	186382220	4772056	14	9469											
FBN2	2201	broad.mit.edu	37	chr5	127671244	127671244	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactgggtgtcacagcctccGttcattatcatacattcatc	6	13	4	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr5:127671244G>A	uc003kuu.2	-	29	4189	c.3750C>T	c.(3748-3750)AAC>AAT	p.N1250N	FBN2_uc003kuv.2_Silent_p.N1217N	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1250	EGF-like 19; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CACAGCCTCCGTTCATTATCA	0.438													A	127671244	A	A	127671244	2	1	138	1	0	0	0	0	0	0	0	1	5703	1136	40	1		1	FBN2	5	127671244	Silent	SNP	G	TCGA-14-1450-01B-01D-1845-08		127671244	53244016	15	9470											
PCDHA3	56145	broad.mit.edu	37	chr5	140181057	140181057	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgaattctcggatagaccGcgaggaactgtgcgggcgga	16	8	1	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr5:140181057G>A	uc003lhf.2	+	1	275	c.275G>A	c.(274-276)CGC>CAC	p.R92H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.R92H	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGATAGACCGCGAGGAACTG	0.587													A	140181057	A	A	140181057	3	1	138	1	0	0	0	0	1	0	0	0	11525	1087	38	1	277	1	PCDHA3	5	140181057	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	12509813	140181057	40734203	16	9471											
N4BP3	23138	broad.mit.edu	37	chr5	177547367	177547367	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccgggcacagctgctgcaCgccctcagcctagatgaggg	14	15	1	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr5:177547367C>T	uc003mik.1	+	3	766	c.519C>T	c.(517-519)CAC>CAT	p.H173H	N4BP3_uc003mil.1_5'Flank	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	173						cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTGCTGCACGCCCTCAGCC	0.711													T	177547367	T	T	177547367	2	4	138	1	0	0	0	0	0	0	0	1	10113	535	19	1		1	N4BP3	5	177547367	Silent	SNP	C	TCGA-14-1450-01B-01D-1845-08	37366310	177547367	3367893	17	9472											
OR2Y1	134083	broad.mit.edu	37	chr5	180166656	180166656	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcagagatgggggtgcatgaTggccatgtagtggagtggac	19	5	0	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr5:180166656T>C	uc003mmf.1	-	1	403	c.403A>G	c.(403-405)ATC>GTC	p.I135V		NM_001001657	NP_001001657	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGTGCATGATGGCCATGTAG	0.587													C	180166656	C	C	180166656	3	2	138	1	0	0	0	0	1	0	0	0	11035	1464	51	4	536	4	OR2Y1	5	180166656	Missense_Mutation	SNP	T	TCGA-14-1450-01B-01D-1845-08	2619289	180166656	748604	18	9473											
PKHD1	5314	broad.mit.edu	37	chr6	51918901	51918901	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttaccatgttttgaaagccGattgtgaaggacacaatcat	8	7	1	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr6:51918901G>A	uc003pah.1	-	20	2175	c.1899C>T	c.(1897-1899)ATC>ATT	p.I633I	PKHD1_uc003pai.2_Silent_p.I633I	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	633	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TTTGAAAGCCGATTGTGAAGG	0.478													A	51918901	A	A	51918901	2	1	138	1	0	0	0	0	0	0	0	1	11971	1048	37	2		2	PKHD1	6	51918901	Silent	SNP	G	TCGA-14-1450-01B-01D-1845-08		51918901	119196166	19	9474											
NMBR	4829	broad.mit.edu	37	chr6	142397171	142397171	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcacaattttagccaggcGtttccgtgtttccatctgca	8	11	1	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr6:142397171G>A	uc003qiu.2	-	3	928	c.787C>T	c.(787-789)CGC>TGC	p.R263C		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	263	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		TTAGCCAGGCGTTTCCGTGTT	0.388													A	142397171	A	A	142397171	3	1	138	1	0	0	0	0	1	0	0	0	10487	1145	40	1	389	1	NMBR	6	142397171	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	90478270	142397171	28717896	20	9475											
PPP1R14C	81706	broad.mit.edu	37	chr6	150464589	150464589	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcggaagcggctggtgctGgaggaatggatcgtggagca	18	7	0	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr6:150464589G>A	uc003qnt.2	+	1	402	c.261G>A	c.(259-261)CTG>CTA	p.L87L		NM_030949	NP_112211	Q8TAE6	PP14C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	87					regulation of phosphorylation	cytoplasm|membrane					0		Ovarian(120;0.0284)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;9.14e-12)		GGCTGGTGCTGGAGGAATGGA	0.637													A	150464589	A	A	150464589	2	1	138	1	0	0	0	0	0	0	0	1	12361	1335	47	3		3	PPP1R14C	6	150464589	Silent	SNP	G	TCGA-14-1450-01B-01D-1845-08	8067418	150464589	20650478	21	9476											
PRPS1L1	221823	broad.mit.edu	37	chr7	18067222	18067222	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cattagactgtcgttgatttCgccacaaccactctgaacga	7	12	1	3			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr7:18067222C>T	uc003stz.2	-	1	265	c.184G>A	c.(184-186)GAA>AAA	p.E62K		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	62					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TCGTTGATTTCGCCACAACCA	0.473													T	18067222	T	T	18067222	3	4	138	1	0	0	0	0	1	0	0	0	12579	893	31	2	776	2	PRPS1L1	7	18067222	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08		18067222	141071441	22	9477											
MLXIPL	51085	broad.mit.edu	37	chr7	73011080	73011080	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggtgtaggggccggggtcgGgggaaggaatgtgcagggga	24	5	0	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr7:73011080G>A	uc003tyn.1	-	11	1759	c.1711C>T	c.(1711-1713)CCG>TCG	p.P571S	MLXIPL_uc003tyj.1_Intron|MLXIPL_uc003tyk.1_Missense_Mutation_p.P571S|MLXIPL_uc003tyl.1_Missense_Mutation_p.P571S|MLXIPL_uc003tym.1_Missense_Mutation_p.P571S|MLXIPL_uc003tyo.1_Intron|MLXIPL_uc003typ.1_Missense_Mutation_p.P477S|MLXIPL_uc003tyq.1_Missense_Mutation_p.P338S	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	571					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				GCCGGGGTCGGGGGAAGGAAT	0.701													A	73011080	A	A	73011080	3	1	138	1	0	0	0	0	1	0	0	0	9637	1232	43	3	875	3	MLXIPL	7	73011080	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	54943858	73011080	86127583	23	9478											
DYNC1I1	1780	broad.mit.edu	37	chr7	95616403	95616403	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccaatctttctttcaatcGtcagttctatgatgaacatt	5	9	5	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr7:95616403G>A	uc003uoc.3	+	9	1107	c.830G>A	c.(829-831)CGT>CAT	p.R277H	DYNC1I1_uc003uod.3_Missense_Mutation_p.R260H|DYNC1I1_uc003uob.2_Missense_Mutation_p.R240H|DYNC1I1_uc003uoe.3_Missense_Mutation_p.R257H|DYNC1I1_uc010lfl.2_Missense_Mutation_p.R266H	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	277					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TCTTTCAATCGTCAGTTCTAT	0.443													A	95616403	A	A	95616403	3	1	138	1	0	0	0	0	1	0	0	0	4842	1145	40	1	860	1	DYNC1I1	7	95616403	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	22605323	95616403	63522260	24	9479											
CYP3A5	1577	broad.mit.edu	37	chr7	99332692	99332692	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggagaagccaggtttccaCggccaagtttgggatgagat	14	8	0	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr7:99332692C>T	uc003urs.2	-	1	130	c.-76G>A	c.(-78--74)CCGTG>CCATG		ZNF498_uc003urn.2_Intron|CYP3A5_uc010lgg.2_Missense_Mutation_p.V9M|CYP3A7_uc003uru.2_Missense_Mutation_p.V9M			P20815	CP3A5_HUMAN	SubName: Full=Cytochrome P450; Flags: Fragment;						alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	CAGGTTTCCACGGCCAAGTTT	0.498													T	99332692	T	T	99332692	1	4	138	1	0	0	0	0	0	0	0	0	4180	536	19	1		1	CYP3A5	7	99332692	Translation_Start_Site	SNP	C	TCGA-14-1450-01B-01D-1845-08	3716289	99332692	59805971	25	9480											
MLL5	55904	broad.mit.edu	37	chr7	104681416	104681416	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtcatgagcatagtgatccCattgggggttgatacagcag	13	8	1	3			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr7:104681416C>T	uc003vcm.2	+	3	551	c.17C>T	c.(16-18)CCA>CTA	p.P6L	MLL5_uc010lja.1_5'UTR|MLL5_uc010ljb.1_Missense_Mutation_p.P6L|MLL5_uc003vcl.2_Missense_Mutation_p.P6L|MLL5_uc010ljc.2_Missense_Mutation_p.P6L	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	6					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						ATAGTGATCCCATTGGGGGTT	0.428													T	104681416	T	T	104681416	3	4	138	1	0	0	0	0	1	0	0	0	9624	594	21	3	19	3	MLL5	7	104681416	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	5348724	104681416	54457247	26	9481											
PRKAR2B	5577	broad.mit.edu	37	chr7	106786905	106786905	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcctggtgctctgtggggttTggtgagtaaaatacttattt	12	5	1	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr7:106786905T>G	uc003vdx.2	+	6	915	c.740T>G	c.(739-741)TTG>TGG	p.L247W		NM_002736	NP_002727	P31323	KAP3_HUMAN	cAMP-dependent protein kinase, regulatory	247	cAMP 1.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1						CTGTGGGGTTTGGTGAGTAAA	0.398													G	106786905	G	G	106786905	3	3	138	1	0	0	0	0	1	0	0	0	12506	1826	63	5	762	5	PRKAR2B	7	106786905	Missense_Mutation	SNP	T	TCGA-14-1450-01B-01D-1845-08	2105489	106786905	52351758	27	9482											
DNAJB5	25822	broad.mit.edu	37	chr9	34996743	34996743	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcaccttccccaaagaaggCgacgccacacctgacaacat	6	16	1	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr9:34996743C>T	uc003zvt.2	+	3	831	c.693C>T	c.(691-693)GGC>GGT	p.G231G	DNAJB5_uc003zvs.2_Silent_p.G265G|DNAJB5_uc011los.1_Silent_p.G303G	NM_012266	NP_036398	O75953	DNJB5_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 5	231					protein folding|response to unfolded protein		heat shock protein binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(32;0.00575)			CCAAAGAAGGCGACGCCACAC	0.562													T	34996743	T	T	34996743	2	4	138	1	0	0	0	0	0	0	0	1	4623	755	27	1		1	DNAJB5	9	34996743	Silent	SNP	C	TCGA-14-1450-01B-01D-1845-08		34996743	106216688	28	9483											
OR13C5	138799	broad.mit.edu	37	chr9	107360795	107360795	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	actgcctccttcacatccttGtttctaagactgtagattaa	5	11	2	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr9:107360795G>T	uc011lvp.1	-	1	900	c.900C>A	c.(898-900)AAC>AAA	p.N300K		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TCACATCCTTGTTTCTAAGAC	0.338													T	107360795	T	T	107360795	3	4	138	1	0	0	0	0	1	0	0	0	10937	1368	48	5	58	5	OR13C5	9	107360795	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	72364052	107360795	33852636	29	9484											
C9orf140	89958	broad.mit.edu	37	chr9	139959160	139959160	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtcctgctggctcagggcgCgggcctcaaacagctgctta	13	14	2	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr9:139959160C>T	uc011men.1	-	6	1252	c.1136G>A	c.(1135-1137)CGC>CAC	p.R379H		NM_178448	NP_848543	Q86UD0	CI140_HUMAN	tumor specificity and mitosis phase-dependent	379	Potential.					cytoplasm|nucleus				skin(1)	1	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;3.02e-05)|Epithelial(140;0.000499)		GCTCAGGGCGCGGGCCTCAAA	0.647											OREG0019628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	139959160	T	T	139959160	3	4	138	1	0	0	0	0	1	0	0	0	2460	768	27	1	52	1	C9orf140	9	139959160	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	32598365	139959160	1254271	30	9485											
SH2D4B	387694	broad.mit.edu	37	chr10	82330026	82330026	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agatctctgaggagctgattGcagagagggcgcggctgcag	17	8	1	4			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr10:82330026G>T	uc001kck.1	+	2	731	c.301G>T	c.(301-303)GCA>TCA	p.A101S	SH2D4B_uc001kcl.1_Missense_Mutation_p.A52S	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	100	Glu-rich.										0			Colorectal(32;0.229)			GGAGCTGATTGCAGAGAGGGC	0.602													T	82330026	T	T	82330026	3	4	138	1	0	0	0	0	1	0	0	0	14236	1319	46	5	348	5	SH2D4B	10	82330026	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08		82330026	53204721	31	9486											
FAM178A	55719	broad.mit.edu	37	chr10	102710503	102710503	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttctcattctttttcttctgGacaacgggtaggtagtgttt	9	7	4	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr10:102710503G>A	uc001krt.3	+	17	3865	c.3323G>A	c.(3322-3324)GGA>GAA	p.G1108E	FAM178A_uc001krs.2_Missense_Mutation_p.G1108E	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	1108											0						TTTTCTTCTGGACAACGGGTA	0.338													A	102710503	A	A	102710503	3	1	138	1	0	0	0	0	1	0	0	0	5503	1174	41	3	3389	3	FAM178A	10	102710503	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	20380477	102710503	32824244	32	9487											
TRIM8	81603	broad.mit.edu	37	chr10	104404874	104404874	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggccgtgtgccagtactGctgctactacagcggcgcgc	15	13	0	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr10:104404874G>A	uc001kvz.2	+	1	623	c.500G>A	c.(499-501)TGC>TAC	p.C167Y		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	167	B box-type 2.					cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		TGCCAGTACTGCTGCTACTAC	0.652													A	104404874	A	A	104404874	3	1	138	1	0	0	0	0	1	0	0	0	16545	1319	46	3	502	3	TRIM8	10	104404874	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	1694371	104404874	31129873	33	9488											
NRAP	4892	broad.mit.edu	37	chr10	115388695	115388695	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcgctgaccagctgtccaGccttcttggcttgttccaag	9	15	1	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr10:115388695G>A	uc001laj.2	-	20	2290	c.2126C>T	c.(2125-2127)GCT>GTT	p.A709V	NRAP_uc009xyb.2_Missense_Mutation_p.A20V|NRAP_uc001lak.2_Missense_Mutation_p.A674V|NRAP_uc001lal.3_Missense_Mutation_p.A709V	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	709	Nebulin 17.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CAGCTGTCCAGCCTTCTTGGC	0.547													A	115388695	A	A	115388695	3	1	138	1	0	0	0	0	1	0	0	0	10638	971	34	3	3158	3	NRAP	10	115388695	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	10983821	115388695	20146052	34	9489											
GFRA1	2674	broad.mit.edu	37	chr10	117884937	117884937	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccttgtggcacttgcggcGgttgcagacatcgttggaca	15	10	0	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr10:117884937G>A	uc001lcj.2	-	6	1263	c.565C>T	c.(565-567)CGC>TGC	p.R189C	GFRA1_uc001lci.2_Missense_Mutation_p.R184C|GFRA1_uc009xyr.2_Missense_Mutation_p.R184C	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	189	2.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CACTTGCGGCGGTTGCAGACA	0.607													A	117884937	A	A	117884937	3	1	138	1	0	0	0	0	1	0	0	0	6347	1116	39	2	856	2	GFRA1	10	117884937	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	2496242	117884937	17649810	35	9490											
MKI67	4288	broad.mit.edu	37	chr10	129905312	129905312	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgattcctcagtgtgacctcGtgtctggaagagctctttaa	10	9	3	3			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr10:129905312G>A	uc001lke.2	-	13	4987	c.4792C>T	c.(4792-4794)CGA>TGA	p.R1598*	MKI67_uc001lkf.2_Nonsense_Mutation_p.R1238*|MKI67_uc009yav.1_Nonsense_Mutation_p.R1173*|MKI67_uc009yaw.1_Nonsense_Mutation_p.R748*	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1598	5.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTGTGACCTCGTGTCTGGAAG	0.488													A	129905312	A	A	129905312	4	1	138	1	0	0	0	0	0	1	0	0	9598	1153	40	1	4990	1	MKI67	10	129905312	Nonsense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	12020375	129905312	5629435	36	9491											
MRGPRX4	117196	broad.mit.edu	37	chr11	18195645	18195645	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtgggctcctttaggcagcGtcaaaataggcagaacctga	12	10	1	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr11:18195645G>A	uc001mnv.1	+	1	1262	c.842G>A	c.(841-843)CGT>CAT	p.R281H		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	281	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						TTTAGGCAGCGTCAAAATAGG	0.498													A	18195645	A	A	18195645	3	1	138	1	0	0	0	0	1	0	0	0	9769	1145	40	1	844	1	MRGPRX4	11	18195645	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08		18195645	116810871	37	9492											
OR5D18	219438	broad.mit.edu	37	chr11	55587380	55587380	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccttgttgtcaaagacagaaCcatttcatttttaggatgcg	8	8	2	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr11:55587380C>A	uc010rin.1	+	1	275	c.275C>A	c.(274-276)ACC>AAC	p.T92N		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				AAAGACAGAACCATTTCATTT	0.418													A	55587380	A	A	55587380	3	1	138	1	0	0	0	0	1	0	0	0	11157	507	18	5	277	5	OR5D18	11	55587380	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	37391735	55587380	79419136	38	9493											
LRRC55	219527	broad.mit.edu	37	chr11	56949947	56949947	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagccacaacccctggctgCggagggtgcatccccaggcc	13	16	0	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr11:56949947C>T	uc001njl.1	+	1	727	c.580C>T	c.(580-582)CGG>TGG	p.R194W		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	164	LRR 4.					integral to membrane					0						CCCCTGGCTGCGGAGGGTGCA	0.617													T	56949947	T	T	56949947	3	4	138	1	0	0	0	0	1	0	0	0	9011	759	27	1	582	1	LRRC55	11	56949947	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	1362567	56949947	78056569	39	9494											
GLYATL2	219970	broad.mit.edu	37	chr11	58605817	58605817	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttgaaagggtttttatcttTtatgttgaaaatggcgccat	10	4	1	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr11:58605817T>C	uc001nnd.3	-	3	234	c.103A>G	c.(103-105)AAA>GAA	p.K35E	GLYATL2_uc009ymq.2_Missense_Mutation_p.K35E	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	35						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TTTTTATCTTTTATGTTGAAA	0.423													C	58605817	C	C	58605817	3	2	138	1	0	0	0	0	1	0	0	0	6481	1850	64	4	797	4	GLYATL2	11	58605817	Missense_Mutation	SNP	T	TCGA-14-1450-01B-01D-1845-08	1655870	58605817	76400699	40	9495											
C11orf82	220042	broad.mit.edu	37	chr11	82643154	82643154	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctaacagataatgatgatttTtcagcttcagaacaaagtaa	6	6	2	4			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr11:82643154T>A	uc001ozt.2	+	6	1018	c.774T>A	c.(772-774)TTT>TTA	p.F258L	C11orf82_uc010rsr.1_5'UTR|C11orf82_uc010rss.1_5'UTR|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	258					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						ATGATGATTTTTCAGCTTCAG	0.413													A	82643154	A	A	82643154	3	1	138	1	0	0	0	0	1	0	0	0	1665	1838	64	5	788	5	C11orf82	11	82643154	Missense_Mutation	SNP	T	TCGA-14-1450-01B-01D-1845-08	24037337	82643154	52363362	41	9496											
DDX10	1662	broad.mit.edu	37	chr11	108788719	108788719	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaagctctgaagattcagaTagtgaagatatggaaaataa	10	3	2	6			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr11:108788719T>C	uc001pkm.2	+	17	2489	c.2424T>C	c.(2422-2424)GAT>GAC	p.D808D	DDX10_uc001pkl.1_Silent_p.D808D	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	808							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		AAGATTCAGATAGTGAAGATA	0.299			T	NUP98	AML*								C	108788719	C	C	108788719	2	2	138	1	0	0	0	0	0	0	0	1	4342	1403	49	4		4	DDX10	11	108788719	Silent	SNP	T	TCGA-14-1450-01B-01D-1845-08	26145565	108788719	26217797	42	9497											
FAM55D	54827	broad.mit.edu	37	chr11	114453240	114453240	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggccagtgaagatcaccctGtcatagccttggttccttgc	10	12	2	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr11:114453240G>A	uc001ppc.2	-	3	781	c.600C>T	c.(598-600)GAC>GAT	p.D200D	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	200						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		AGATCACCCTGTCATAGCCTT	0.532													A	114453240	A	A	114453240	2	1	138	1	0	0	0	0	0	0	0	1	5587	1368	48	3		3	FAM55D	11	114453240	Silent	SNP	G	TCGA-14-1450-01B-01D-1845-08	5664521	114453240	20553276	43	9498											
ETS1	2113	broad.mit.edu	37	chr11	128354828	128354828	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagggtctcggagaatgaccGaggggtagtcattctcatac	14	8	3	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr11:128354828G>A	uc010sbs.1	-	5	936	c.620C>T	c.(619-621)TCG>TTG	p.S207L	ETS1_uc001qej.2_Missense_Mutation_p.S251L|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Missense_Mutation_p.S207L	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	207					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		GAGAATGACCGAGGGGTAGTC	0.522													A	128354828	A	A	128354828	3	1	138	1	0	0	0	0	1	0	0	0	5275	1059	37	2	721	2	ETS1	11	128354828	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	13901588	128354828	6651688	44	9499											
GDF3	9573	broad.mit.edu	37	chr12	7848193	7848193	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aagatataaggcacaggttgGaacttctggggtgaaggcgc	15	6	1	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr12:7848193G>A	uc001qte.2	-	1	168	c.132C>T	c.(130-132)TTC>TTT	p.F44F		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	44					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						GCACAGGTTGGAACTTCTGGG	0.498													A	7848193	A	A	7848193	2	1	138	1	0	0	0	0	0	0	0	1	6315	1165	41	3		3	GDF3	12	7848193	Silent	SNP	G	TCGA-14-1450-01B-01D-1845-08		7848193	126003702	45	9500											
GLI1	2735	broad.mit.edu	37	chr12	57861990	57861990	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gggaggaaagcagactgactGtgccagagggtgccatggtg	18	7	0	3			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr12:57861990G>C	uc001snx.2	+	10	1369	c.1291G>C	c.(1291-1293)GTG>CTG	p.V431L	GLI1_uc009zpq.2_Missense_Mutation_p.V303L	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	431					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CAGACTGACTGTGCCAGAGGG	0.602													C	57861990	C	C	57861990	3	2	138	1	0	0	0	0	1	0	0	0	6437	1377	48	5	1325	5	GLI1	12	57861990	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	50013797	57861990	75989905	46	9501											
LGR5	8549	broad.mit.edu	37	chr12	71974190	71974190	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cataagaaagatgctggaatGtttcaggctcaaggtaggac	12	6	2	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr12:71974190G>A	uc001swl.2	+	16	1587	c.1539G>A	c.(1537-1539)ATG>ATA	p.M513I	LGR5_uc001swm.2_Missense_Mutation_p.M489I|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	513	Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						ATGCTGGAATGTTTCAGGCTC	0.388													A	71974190	A	A	71974190	3	1	138	1	0	0	0	0	1	0	0	0	8757	1377	48	3	1601	3	LGR5	12	71974190	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	14112200	71974190	61877705	47	9502											
C12orf51	283450	broad.mit.edu	37	chr12	112622897	112622897	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggacgaggaggaggaggaCgagtcactgagatttggggc	20	5	1	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr12:112622897C>T	uc009zwc.2	-	54	8625	c.8607G>A	c.(8605-8607)TCG>TCA	p.S2869S		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						AGGAGGAGGACGAGTCACTGA	0.592													T	112622897	T	T	112622897	2	4	138	1	0	0	0	0	0	0	0	1	1696	523	19	1		1	C12orf51	12	112622897	Silent	SNP	C	TCGA-14-1450-01B-01D-1845-08	40648707	112622897	21228998	48	9503											
TUBA3C	7278	broad.mit.edu	37	chr13	19752399	19752399	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcttaccagtttgcggatcCggtccaggaccaggtcgacg	12	12	1	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr13:19752399C>T	uc009zzj.2	-	3	411	c.362G>A	c.(361-363)CGG>CAG	p.R121Q		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	121					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TTTGCGGATCCGGTCCAGGAC	0.522													T	19752399	T	T	19752399	3	4	138	1	0	0	0	0	1	0	0	0	16743	652	23	2	1002	2	TUBA3C	13	19752399	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08		19752399	95417479	49	9504											
FLT1	2321	broad.mit.edu	37	chr13	28919630	28919630	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aataggagccagaagagagtCgcagccacacaggtgcatgt	13	9	0	2	rs142392658		TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr13:28919630C>T	uc001usb.3	-	16	2592	c.2307G>A	c.(2305-2307)GCG>GCA	p.A769A	FLT1_uc001usa.3_5'UTR	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	769	Helical; (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity	p.A769S(1)		lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AGAAGAGAGTCGCAGCCACAC	0.398													T	28919630	T	T	28919630	2	4	138	1	0	0	0	0	0	0	0	1	5941	871	31	2		2	FLT1	13	28919630	Silent	SNP	C	TCGA-14-1450-01B-01D-1845-08	9167231	28919630	86250248	50	9505											
TEP1	7011	broad.mit.edu	37	chr14	20871545	20871545	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagggactcacctttctctgCtcttctctgagaaaccctat	6	13	4	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr14:20871545C>T	uc001vxe.2	-	7	1297	c.1257G>A	c.(1255-1257)GAG>GAA	p.E419E	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.E311E	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	419	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CCTTTCTCTGCTCTTCTCTGA	0.408													T	20871545	T	T	20871545	2	4	138	1	0	0	0	0	0	0	0	1	15756	796	28	3		3	TEP1	14	20871545	Silent	SNP	C	TCGA-14-1450-01B-01D-1845-08		20871545	86477995	51	9506											
OSGEP	55644	broad.mit.edu	37	chr14	20917163	20917163	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gttgtatcctggacttgggtCgttagaaatctagcagaaga	12	6	1	3			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr14:20917163C>T	uc001vxf.2	-	5	873	c.517G>A	c.(517-519)GAC>AAC	p.D173N		NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	173					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		GGACTTGGGTCGTTAGAAATC	0.448													T	20917163	T	T	20917163	3	4	138	1	0	0	0	0	1	0	0	0	11287	884	31	2	518	2	OSGEP	14	20917163	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	45618	20917163	86432377	52	9507											
PAPOLA	10914	broad.mit.edu	37	chr14	97022277	97022277	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caagtaaattccagtgaaagCtcagggggtaaggagattgg	14	5	1	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr14:97022277C>G	uc001yfq.2	+	18	1968	c.1758C>G	c.(1756-1758)AGC>AGG	p.S586R	PAPOLA_uc001yfr.2_Missense_Mutation_p.S585R|PAPOLA_uc010twv.1_Missense_Mutation_p.S586R|PAPOLA_uc010avp.2_Missense_Mutation_p.S336R	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	586	Ser/Thr-rich.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		CCAGTGAAAGCTCAGGGGGTA	0.398													G	97022277	G	G	97022277	3	3	138	1	0	0	0	0	1	0	0	0	11429	796	28	5	1828	5	PAPOLA	14	97022277	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	76105114	97022277	10327263	53	9508											
AHNAK2	113146	broad.mit.edu	37	chr14	105417016	105417016	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catctatctggggccccttgAggtccactttgggcatcttg	11	12	3	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr14:105417016A>T	uc010axc.1	-	7	4892	c.4772T>A	c.(4771-4773)CTC>CAC	p.L1591H	AHNAK2_uc001ypx.2_Missense_Mutation_p.L1491H	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1591						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGCCCCTTGAGGTCCACTTT	0.592													T	105417016	T	T	105417016	3	4	138	1	0	0	0	0	1	0	0	0	415	304	11	5	12619	5	AHNAK2	14	105417016	Missense_Mutation	SNP	A	TCGA-14-1450-01B-01D-1845-08	8394739	105417016	1932524	54	9509											
TJP1	7082	broad.mit.edu	37	chr15	30012191	30012192	+	Frame_Shift_Ins	INS	-	T	T													ggtttgtttcaggcgaaaggINStaagggactggagatgaagc							TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr15:30012191_30012192insT	uc001zcr.2	-	20	3267_3268	c.2792_2793insA	c.(2791-2793)TACfs	p.Y931fs	TJP1_uc010azl.2_Frame_Shift_Ins_p.Y919fs|TJP1_uc001zcq.2_Intron|TJP1_uc001zcs.2_Intron	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	931					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CAGGCGAAAGGTAAGGGACTGG	0.386													T	30012192	T	T	30012191	7	5	138	1	0	1	1	0	0	0	0	0	15926	1256	44	0	2489	0	TJP1	15	30012191	Frame_Shift_Ins	INS	-	TCGA-14-1450-01B-01D-1845-08		30012191	72519201	55	9510											
NEDD4L	23327	broad.mit.edu	37	chr18	55992284	55992286	+	In_Frame_Del	DEL	TCC	-	-													tctcagcaccaagaggaactTcctcctcctcctctgcctcc							TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr18:55992284_55992286delTCC	uc002lgy.2	+	9	844_846	c.570_572delTCC	c.(568-573)CTTCCT>CTT	p.P194del	NEDD4L_uc002lgz.2_In_Frame_Del_p.P194del|NEDD4L_uc002lgx.2_In_Frame_Del_p.P194del|NEDD4L_uc010xee.1_In_Frame_Del_p.P73del|NEDD4L_uc002lhc.2_In_Frame_Del_p.P186del|NEDD4L_uc002lhd.2_In_Frame_Del_p.P73del|NEDD4L_uc002lhb.2_In_Frame_Del_p.P73del|NEDD4L_uc002lhe.2_In_Frame_Del_p.P186del|NEDD4L_uc002lhf.2_In_Frame_Del_p.P73del|NEDD4L_uc002lhg.2_In_Frame_Del_p.P73del|NEDD4L_uc002lhh.2_In_Frame_Del_p.P73del|NEDD4L_uc010dpm.1_In_Frame_Del_p.P45del	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	194	WW 1.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						AAGAGGAACTTCCTCCTCCTCCT	0.498													-	55992286	-	-	55992284	7	5	138	1	0	1	0	1	0	0	0	0	10311	1770	62	0	632	0	NEDD4L	18	55992284	In_Frame_Del	DEL	TCC	TCGA-14-1450-01B-01D-1845-08		55992284	22084964	56	9511											
DAPK3	1613	broad.mit.edu	37	chr19	3959627	3959627	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaccacgcacgttccgccgCcggatcgcctaggaaggagg	13	15	1	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr19:3959627C>T	uc002lzc.1	-	8	930	c.837G>A	c.(835-837)CGG>CGA	p.R279R	DAPK3_uc002lzb.1_Silent_p.R16R|DAPK3_uc002lzd.1_Silent_p.R279R	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	279					apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTTCCGCCGCCGGATCGCCT	0.687													T	3959627	T	T	3959627	2	4	138	1	0	0	0	0	0	0	0	1	4237	726	26	3		3	DAPK3	19	3959627	Silent	SNP	C	TCGA-14-1450-01B-01D-1845-08		3959627	55169356	57	9512											
UBXN6	80700	broad.mit.edu	37	chr19	4454085	4454085	+	Frame_Shift_Del	DEL	T	-	-													tgggcttctctttgtgggccTtttccctgggaacagaccga							TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr19:4454085delT	uc002man.1	-	2	185	c.89delA	c.(88-90)AAGfs	p.K30fs	UBXN6_uc010dty.1_5'UTR|UBXN6_uc002mam.1_5'UTR	NM_025241	NP_079517	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	30						microtubule organizing center|nucleus	protein binding				0						TTTGTGGGCCTTTTCCCTGGG	0.667													-	4454085	-	-	4454085	7	5	138	1	0	1	0	1	0	0	0	0	16914	1609	56	0	1276	0	UBXN6	19	4454085	Frame_Shift_Del	DEL	T	TCGA-14-1450-01B-01D-1845-08	494458	4454085	54674898	58	9513											
KHSRP	8570	broad.mit.edu	37	chr19	6416419	6416419	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccaactgggcagagaggaccCtagaaggaaggagagtaacc	14	9	0	3			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr19:6416419C>A	uc002mer.3	-	15	1599	c.1489_splice	c.e15-1	p.G497_splice		NM_003685	NP_003676	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein						mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1						AGAGAGGACCCTAGAAGGAAG	0.637													A	6416419	A	A	6416419	5	1	138	1	0	0	0	0	0	0	1	0	8151	695	24	5	671	5	KHSRP	19	6416419	Splice_Site	SNP	C	TCGA-14-1450-01B-01D-1845-08	1962334	6416419	52712564	59	9514											
TSPAN16	26526	broad.mit.edu	37	chr19	11417292	11417292	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctatagctaaagtgctgtGgggtgaataactacacagat	10	7	1	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr19:11417292G>A	uc002mqv.1	+	5	613	c.463G>A	c.(463-465)GGG>AGG	p.G155R	TSPAN16_uc002mqu.1_RNA|uc002mqw.1_Intron	NM_012466	NP_036598	Q9UKR8	TSN16_HUMAN	transmembrane 4 superfamily member 16	155	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AAAGTGCTGTGGGGTGAATAA	0.438													A	11417292	A	A	11417292	3	1	138	1	0	0	0	0	1	0	0	0	16637	1348	47	3	481	3	TSPAN16	19	11417292	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	5000873	11417292	47711691	60	9515											
NOTCH3	4854	broad.mit.edu	37	chr19	15272328	15272328	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagcagaggccccaggccGtggggaccgggggggctgcg	21	12	0	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr19:15272328G>A	uc002nan.2	-	33	6187	c.6111C>T	c.(6109-6111)CAC>CAT	p.H2037H		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	2037	Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			GCCCCAGGCCGTGGGGACCGG	0.682													A	15272328	A	A	15272328	2	1	138	1	0	0	0	0	0	0	0	1	10550	1136	40	1		1	NOTCH3	19	15272328	Silent	SNP	G	TCGA-14-1450-01B-01D-1845-08	3855036	15272328	43856655	61	9516											
TSKS	60385	broad.mit.edu	37	chr19	50251361	50251361	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttgagttgaatgcagtacCcctccaactcttctgcctct	6	15	3	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr19:50251361C>T	uc002ppm.2	-	4	571	c.560G>A	c.(559-561)GGG>GAG	p.G187E		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	187							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		AATGCAGTACCCCTCCAACTC	0.547													T	50251361	T	T	50251361	3	4	138	1	0	0	0	0	1	0	0	0	16623	623	22	3	1250	3	TSKS	19	50251361	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	34979033	50251361	8877622	62	9517											
ASXL1	171023	broad.mit.edu	37	chr20	31022345	31022345	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgccggggttggactggCgccaggaccctcgcagacat	14	14	0	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr20:31022345C>T	uc002wxs.2	+	12	2256	c.1830C>T	c.(1828-1830)GGC>GGT	p.G610G	ASXL1_uc010geb.2_Silent_p.G501G	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	610					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.Q592fs*5(1)|p.G610G(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GTTGGACTGGCGCCAGGACCC	0.632			F|N|Mis		MDS|CMML								T	31022345	T	T	31022345	2	4	138	1	0	0	0	0	0	0	0	1	1066	755	27	1		1	ASXL1	20	31022345	Silent	SNP	C	TCGA-14-1450-01B-01D-1845-08		31022345	32003175	63	9518											
C20orf152	140894	broad.mit.edu	37	chr20	34560629	34560629	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaaggcctcaggggattcCgggaatatcaaatcattgag	12	9	3	1	rs150690141	byFrequency	TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr20:34560629C>T	uc002xes.1	+	2	286	c.130C>T	c.(130-132)CGG>TGG	p.R44W	C20orf152_uc002xer.1_Missense_Mutation_p.R44W|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	44											0	Breast(12;0.00631)					CAGGGGATTCCGGGAATATCA	0.443													T	34560629	T	T	34560629	3	4	138	1	0	0	0	0	1	0	0	0	2092	643	23	2	136	2	C20orf152	20	34560629	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	3538284	34560629	28464891	64	9519											
TIAM1	7074	broad.mit.edu	37	chr21	32638854	32638854	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taggaatgctgcctcctgccTccctcagccaaatatgtagc	8	14	1	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chr21:32638854T>C	uc002yow.1	-	5	907	c.435A>G	c.(433-435)GGA>GGG	p.G145G	TIAM1_uc011adk.1_Silent_p.G145G|TIAM1_uc011adl.1_Silent_p.G145G|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	145					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GCCTCCTGCCTCCCTCAGCCA	0.547													C	32638854	C	C	32638854	2	2	138	1	0	0	0	0	0	0	0	1	15887	1538	54	4		4	TIAM1	21	32638854	Silent	SNP	T	TCGA-14-1450-01B-01D-1845-08		32638854	15491041	65	9520											
MAP3K15	389840	broad.mit.edu	37	chrX	19391804	19391804	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagggccaggacgacaccgCggggaccttctgtaggggga	18	11	1	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chrX:19391804C>T	uc004czk.1	-	22	2845	c.1208G>A	c.(1207-1209)CGC>CAC	p.R403H	MAP3K15_uc004czj.1_Missense_Mutation_p.R363H|MAP3K15_uc004czi.1_5'Flank	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	928							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					GACGACACCGCGGGGACCTTC	0.677													T	19391804	T	T	19391804	3	4	138	1	0	0	0	0	1	0	0	0	9249	768	27	1	1194	1	MAP3K15	23	19391804	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08		19391804	135878756	66	9521											
ZNF41	7592	broad.mit.edu	37	chrX	47307679	47307679	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacctttccacattctgtaCatatatagggtttctctccg	6	11	2	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chrX:47307679C>T	uc004dhs.3	-	4	1683	c.1616G>A	c.(1615-1617)TGT>TAT	p.C539Y	ZNF41_uc004dhu.3_Missense_Mutation_p.C531Y|ZNF41_uc004dht.3_Missense_Mutation_p.C411Y|ZNF41_uc004dhv.3_Missense_Mutation_p.C507Y|ZNF41_uc004dhw.3_Missense_Mutation_p.C499Y|ZNF41_uc004dhy.3_Missense_Mutation_p.C497Y|ZNF41_uc004dhx.3_Missense_Mutation_p.C497Y|ZNF41_uc011mlm.1_Missense_Mutation_p.C411Y	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	539	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				ACATTCTGTACATATATAGGG	0.428													T	47307679	T	T	47307679	3	4	138	1	0	0	0	0	1	0	0	0	17886	478	17	3	853	3	ZNF41	23	47307679	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	27915875	47307679	107962881	67	9522											
GSPT2	23708	broad.mit.edu	37	chrX	51487380	51487380	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgctggcaagtcaaccatcGgaggacagataatgtttttg	11	8	1	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chrX:51487380G>A	uc004dpl.2	+	1	884	c.658G>A	c.(658-660)GGA>AGA	p.G220R		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	220					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					GTCAACCATCGGAGGACAGAT	0.398													A	51487380	A	A	51487380	3	1	138	1	0	0	0	0	1	0	0	0	6827	1117	39	2	660	2	GSPT2	23	51487380	Missense_Mutation	SNP	G	TCGA-14-1450-01B-01D-1845-08	4179701	51487380	103783180	68	9523											
ODZ1	10178	broad.mit.edu	37	chrX	123518365	123518365	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttatgtcacatattaccatgCggcccacattatcatattga	5	10	2	1			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chrX:123518365C>T	uc004euj.2	-	29	6459	c.6395G>A	c.(6394-6396)CGC>CAC	p.R2132H	ODZ1_uc011muj.1_Missense_Mutation_p.R2138H|ODZ1_uc010nqy.2_Missense_Mutation_p.R2139H	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2132	Extracellular (Potential).|YD 16.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TATTACCATGCGGCCCACATT	0.393													T	123518365	T	T	123518365	3	4	138	1	0	0	0	0	1	0	0	0	10834	768	27	1	1794	1	ODZ1	23	123518365	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	72030985	123518365	31752195	69	9524											
ACTRT1	139741	broad.mit.edu	37	chrX	127185914	127185914	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caagctcccgctcaaagagaTgtttccagagtttctccatg	8	12	2	2			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chrX:127185914T>G	uc004eum.2	-	1	469	c.272A>C	c.(271-273)CAT>CCT	p.H91P		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	91						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						CTCAAAGAGATGTTTCCAGAG	0.493													G	127185914	G	G	127185914	3	3	138	1	0	0	0	0	1	0	0	0	218	1464	51	5	862	5	ACTRT1	23	127185914	Missense_Mutation	SNP	T	TCGA-14-1450-01B-01D-1845-08	3667549	127185914	28084646	70	9525											
ARHGEF6	9459	broad.mit.edu	37	chrX	135754253	135754253	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcttcctcagggagtaggacTtgtggaatggaatcttttcg	12	7	3	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chrX:135754253T>A	uc004fab.2	-	20	2523	c.2061A>T	c.(2059-2061)CAA>CAT	p.Q687H	ARHGEF6_uc011mwd.1_Missense_Mutation_p.Q560H|ARHGEF6_uc011mwe.1_Missense_Mutation_p.Q533H	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	687					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					GGAGTAGGACTTGTGGAATGG	0.458													A	135754253	A	A	135754253	3	1	138	1	0	0	0	0	1	0	0	0	910	1606	56	5	281	5	ARHGEF6	23	135754253	Missense_Mutation	SNP	T	TCGA-14-1450-01B-01D-1845-08	8568339	135754253	19516307	71	9526											
PNCK	139728	broad.mit.edu	37	chrX	152936012	152936012	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggatctgccccagcttcCggatgtggcgcaggaacgag	15	12	1	0			TCGA-14-1450-01B-01D-1845-08	TCGA-14-1450-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ec7f174-13f6-44b1-83e3-6f35a244f00e	07ac31bd-1aa0-4e13-8705-16f627eb7c7a	g.chrX:152936012C>T	uc011myu.1	-	11	1367	c.1181G>A	c.(1180-1182)CGG>CAG	p.R394Q	PNCK_uc011myt.1_Missense_Mutation_p.R328Q|PNCK_uc004fia.2_Missense_Mutation_p.R346Q|PNCK_uc004fhz.3_Missense_Mutation_p.R209Q	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	311	Calmodulin-binding (By similarity).					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCCAGCTTCCGGATGTGGCG	0.687													T	152936012	T	T	152936012	3	4	138	1	0	0	0	0	1	0	0	0	12145	652	23	2	103	2	PNCK	23	152936012	Missense_Mutation	SNP	C	TCGA-14-1450-01B-01D-1845-08	17181759	152936012	2334548	72	9527											
CATSPER4	378807	broad.mit.edu	37	chr1	26524560	26524560	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcatggtcctcatcctcttcTtcatgctggtcagtgcctgc	8	14	6	0			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr1:26524560T>G	uc010oez.1	+	5	670	c.670T>G	c.(670-672)TTC>GTC	p.F224V	CATSPER4_uc010oey.1_Missense_Mutation_p.F46V|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	224	Helical; Name=Segment S5; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		CATCCTCTTCTTCATGCTGGT	0.597													G	26524560	G	G	26524560	3	3	139	1	0	0	0	0	1	0	0	0	2690	1609	56	5	688	5	CATSPER4	1	26524560	Missense_Mutation	SNP	T	TCGA-14-1456-01B-01D-1494-08		26524560	222726061	1	9528											
SDCCAG8	10806	broad.mit.edu	37	chr1	243507526	243507526	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	caatctaacaggtgtgtggaGaaatgcgctatcagctgaat	11	7	2	2			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr1:243507526G>C	uc001hzw.2	+	12	1522	c.1366G>C	c.(1366-1368)GAA>CAA	p.E456Q	SDCCAG8_uc010pyk.1_Missense_Mutation_p.E311Q|SDCCAG8_uc010pyl.1_Missense_Mutation_p.E268Q|SDCCAG8_uc001hzx.2_Missense_Mutation_p.E268Q	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	456	Potential.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		GGTGTGTGGAGAAATGCGCTA	0.423													C	243507526	C	C	243507526	3	2	139	1	0	0	0	0	1	0	0	0	13959	943	33	5	1412	5	SDCCAG8	1	243507526	Missense_Mutation	SNP	G	TCGA-14-1456-01B-01D-1494-08	216982966	243507526	5743095	2	9529			1	30		2	2	49	G		4.961637e-05
SDCCAG8	10806	broad.mit.edu	37	chr1	243507574	243507574	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	acatggagaaggatgaggcaGaaaaggagcacagagagttc	15	5	0	4			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr1:243507574G>A	uc001hzw.2	+	12	1570	c.1414G>A	c.(1414-1416)GAA>AAA	p.E472K	SDCCAG8_uc010pyk.1_Missense_Mutation_p.E327K|SDCCAG8_uc010pyl.1_Missense_Mutation_p.E284K|SDCCAG8_uc001hzx.2_Missense_Mutation_p.E284K	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	472	Potential.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		GGATGAGGCAGAAAAGGAGCA	0.393													A	243507574	A	A	243507574	3	1	139	1	0	0	0	0	1	0	0	0	13959	943	33	3	1460	3	SDCCAG8	1	243507574	Missense_Mutation	SNP	G	TCGA-14-1456-01B-01D-1494-08	48	243507574	5743047	3	9530			1	30		2	2	49	G		4.961637e-05
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	139	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08		209113112	34086261	4	9531											
ALPPL2	251	broad.mit.edu	37	chr2	233274433	233274433	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagcgcacgtcatggccttcGccgcctgcctggagccctac	11	17	1	0			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr2:233274433G>A	uc002vss.3	+	11	1503	c.1450G>A	c.(1450-1452)GCC>ACC	p.A484T		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	484					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CATGGCCTTCGCCGCCTGCCT	0.751													A	233274433	A	A	233274433	3	1	139	1	0	0	0	0	1	0	0	0	549	1087	38	1	1492	1	ALPPL2	2	233274433	Missense_Mutation	SNP	G	TCGA-14-1456-01B-01D-1494-08	24161321	233274433	9924940	5	9532											
SPP2	6694	broad.mit.edu	37	chr2	234967503	234967503	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaggtcctagatgagaacaaCttggtcatgaatttagagtt	11	5	1	4			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr2:234967503C>G	uc002vvk.1	+	3	319	c.234C>G	c.(232-234)AAC>AAG	p.N78K	SPP2_uc010fyl.1_5'UTR	NM_006944	NP_008875	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa precursor	78					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity				0		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		ATGAGAACAACTTGGTCATGA	0.423													G	234967503	G	G	234967503	3	3	139	1	0	0	0	0	1	0	0	0	15086	564	20	5	244	5	SPP2	2	234967503	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08	1693070	234967503	8231870	6	9533											
PER2	8864	broad.mit.edu	37	chr2	239157759	239157759	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catccactggtggacctcgcGcagctcctgcttctgactct	9	16	2	1			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr2:239157759G>A	uc002vyc.2	-	22	3799	c.3562C>T	c.(3562-3564)CGC>TGC	p.R1188C	PER2_uc010znv.1_Missense_Mutation_p.R1188C	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	1188	CRY binding domain (By similarity).				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TGGACCTCGCGCAGCTCCTGC	0.567													A	239157759	A	A	239157759	3	1	139	1	0	0	0	0	1	0	0	0	11730	1087	38	1	213	1	PER2	2	239157759	Missense_Mutation	SNP	G	TCGA-14-1456-01B-01D-1494-08	4190256	239157759	4041614	7	9534											
PIK3R1	5295	broad.mit.edu	37	chr5	67589147	67589147	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaggaaagggggaaataacAaattaatcaaaatatttcat	7	4	2	0			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr5:67589147A>G	uc003jva.2	+	10	1695	c.1135A>G	c.(1135-1137)AAA>GAA	p.K379E	PIK3R1_uc003jvb.2_Missense_Mutation_p.K379E|PIK3R1_uc003jvc.2_Missense_Mutation_p.K79E|PIK3R1_uc003jvd.2_Missense_Mutation_p.K109E|PIK3R1_uc003jve.2_Missense_Mutation_p.K58E|PIK3R1_uc011crb.1_Missense_Mutation_p.K49E	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	379	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GGGAAATAACAAATTAATCAA	0.308			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			G	67589147	G	G	67589147	3	3	139	1	0	0	0	0	1	0	0	0	11918	131	5	4	1299	4	PIK3R1	5	67589147	Missense_Mutation	SNP	A	TCGA-14-1456-01B-01D-1494-08		67589147	113326113	8	9535											
ARSK	153642	broad.mit.edu	37	chr5	94936730	94936730	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcgaactaaccactggaaaTatatagcctattcggatggt	8	8	0	0			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr5:94936730T>C	uc003kld.2	+	7	1434	c.1276T>C	c.(1276-1278)TAT>CAT	p.Y426H	ARSK_uc010jbg.2_Missense_Mutation_p.Y267H|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	426						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		CCACTGGAAATATATAGCCTA	0.343													C	94936730	C	C	94936730	3	2	139	1	0	0	0	0	1	0	0	0	996	1406	49	4	1302	4	ARSK	5	94936730	Missense_Mutation	SNP	T	TCGA-14-1456-01B-01D-1494-08	27347583	94936730	85978530	9	9536											
MSH5	4439	broad.mit.edu	37	chr6	31729252	31729252	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctctgccctctttgcaggtgGatgggctcgcgcttctggcc	13	14	3	0			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr6:31729252G>A	uc003nwv.1	+	22	2120	c.2041G>A	c.(2041-2043)GAT>AAT	p.D681N	MSH5_uc003nwt.1_Missense_Mutation_p.D698N|MSH5_uc003nwu.1_Missense_Mutation_p.D682N|MSH5_uc003nww.1_Missense_Mutation_p.D681N|MSH5_uc003nwx.1_Missense_Mutation_p.D699N|MSH5_uc011dof.1_Missense_Mutation_p.D380N|MSH5_uc003nwy.1_Missense_Mutation_p.D355N|MSH5_uc003nwz.3_RNA|C6orf26_uc003nxa.3_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	681					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						TTTGCAGGTGGATGGGCTCGC	0.577								Direct_reversal_of_damage|MMR					A	31729252	A	A	31729252	3	1	139	1	0	0	0	0	1	0	0	0	9873	1174	41	3	2177	3	MSH5	6	31729252	Missense_Mutation	SNP	G	TCGA-14-1456-01B-01D-1494-08		31729252	139385815	10	9537											
CD2AP	23607	broad.mit.edu	37	chr6	47547178	47547178	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atggtaaagaaggagtatttCcagacaattttgctgtccag	10	6	0	2			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr6:47547178C>T	uc003oyw.2	+	9	1417	c.961C>T	c.(961-963)CCA>TCA	p.P321S		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	321	SH3 3.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AGGAGTATTTCCAGACAATTT	0.343													T	47547178	T	T	47547178	3	4	139	1	0	0	0	0	1	0	0	0	2994	855	30	3	995	3	CD2AP	6	47547178	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08	15817926	47547178	123567889	11	9538											
EPHA7	2045	broad.mit.edu	37	chr6	94120318	94120318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgcagtgcatcctgggggCgttttccgcttcttcctctg	11	13	2	0	rs41273629	byFrequency	TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr6:94120318C>T	uc003poe.2	-	3	974	c.733G>A	c.(733-735)GCC>ACC	p.A245T	EPHA7_uc003pof.2_Missense_Mutation_p.A245T|EPHA7_uc011eac.1_Missense_Mutation_p.A245T|EPHA7_uc003pog.3_Missense_Mutation_p.A245T	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	245	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		ATCCTGGGGGCGTTTTCCGCT	0.483													T	94120318	T	T	94120318	3	4	139	1	0	0	0	0	1	0	0	0	5172	768	27	1	2323	1	EPHA7	6	94120318	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08	46573140	94120318	76994749	12	9539											
CCDC129	223075	broad.mit.edu	37	chr7	31614260	31614260	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcatgcaaatcccagccagaTtccttggttgtggctcagca	10	12	1	1			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr7:31614260T>A	uc003tcj.1	+	7	1495	c.502T>A	c.(502-504)TTC>ATC	p.F168I	CCDC129_uc011kad.1_Missense_Mutation_p.F178I|CCDC129_uc003tci.1_Missense_Mutation_p.F167I|CCDC129_uc011kae.1_Missense_Mutation_p.F194I|CCDC129_uc003tck.1_Missense_Mutation_p.F76I	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	168											0						CCCAGCCAGATTCCTTGGTTG	0.478													A	31614260	A	A	31614260	3	1	139	1	0	0	0	0	1	0	0	0	2764	1493	52	5	524	5	CCDC129	7	31614260	Missense_Mutation	SNP	T	TCGA-14-1456-01B-01D-1494-08		31614260	127524403	13	9540											
EGFR	1956	broad.mit.edu	37	chr7	55219021	55219021	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaagctgtcccaatgggagCtgctggggtgcaggagagga	17	9	0	1			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr7:55219021C>T	uc003tqk.2	+	5	840	c.594C>T	c.(592-594)AGC>AGT	p.S198S	EGFR_uc003tqh.2_Silent_p.S198S|EGFR_uc003tqi.2_Silent_p.S198S|EGFR_uc003tqj.2_Silent_p.S198S|EGFR_uc010kzg.1_Silent_p.S153S|EGFR_uc011kco.1_Silent_p.S145S|EGFR_uc003tql.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	198	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCAATGGGAGCTGCTGGGGTG	0.493		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55219021	T	T	55219021	2	4	139	1	0	0	0	0	0	0	0	1	4967	796	28	3		3	EGFR	7	55219021	Silent	SNP	C	TCGA-14-1456-01B-01D-1494-08	23604761	55219021	103919642	14	9541											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	139	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08	2801	55221822	103916841	15	9542											
SULF1	23213	broad.mit.edu	37	chr8	70488235	70488235	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtcatgaacaaaacgagaaAgattatggaacatggggggg	14	4	1	3			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr8:70488235A>C	uc010lza.1	+	6	920	c.203A>C	c.(202-204)AAG>ACG	p.K68T	SULF1_uc003xyd.2_Missense_Mutation_p.K68T|SULF1_uc003xye.2_Missense_Mutation_p.K68T|SULF1_uc003xyf.2_Missense_Mutation_p.K68T|SULF1_uc003xyg.2_Missense_Mutation_p.K68T	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	68					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AAAACGAGAAAGATTATGGAA	0.517													C	70488235	C	C	70488235	3	2	139	1	0	0	0	0	1	0	0	0	15369	72	3	5	209	5	SULF1	8	70488235	Missense_Mutation	SNP	A	TCGA-14-1456-01B-01D-1494-08		70488235	75875787	16	9543											
ZNF251	90987	broad.mit.edu	37	chr8	145947815	145947815	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttaaaaccaaaggctctgccGcattcattacatacataggg	7	10	2	0			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr8:145947815G>A	uc003zdv.3	-	5	1486	c.1230C>T	c.(1228-1230)TGC>TGT	p.C410C		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	410	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		AGGCTCTGCCGCATTCATTAC	0.443													A	145947815	A	A	145947815	2	1	139	1	0	0	0	0	0	0	0	1	17793	1079	38	1		1	ZNF251	8	145947815	Silent	SNP	G	TCGA-14-1456-01B-01D-1494-08	75459580	145947815	416207	17	9544											
GABBR2	9568	broad.mit.edu	37	chr9	101052880	101052880	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccacccttacaggcccgagaCcatgactcggaaggagggtg	13	13	0	2			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr9:101052880C>G	uc004ays.2	-	19	2968	c.2812G>C	c.(2812-2814)GTC>CTC	p.V938L		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	938	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	AGGCCCGAGACCATGACTCGG	0.687													G	101052880	G	G	101052880	3	3	139	1	0	0	0	0	1	0	0	0	6156	507	18	5	17	5	GABBR2	9	101052880	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08		101052880	40160551	18	9545											
FUT7	2529	broad.mit.edu	37	chr9	139925805	139925805	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcctcggaggtggctgaggCcgtgggtgtggctaggagac	20	8	0	2			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr9:139925805C>T	uc004ckq.2	-	2	1235	c.386G>A	c.(385-387)GGC>GAC	p.G129D	ABCA2_uc004ckm.1_5'Flank|C9orf139_uc004ckp.1_Intron	NM_004479	NP_004470	Q11130	FUT7_HUMAN	fucosyltransferase 7	129	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		GTGGCTGAGGCCGTGGGTGTG	0.711													T	139925805	T	T	139925805	3	4	139	1	0	0	0	0	1	0	0	0	6109	739	26	3	646	3	FUT7	9	139925805	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08	38872925	139925805	1287626	19	9546											
OGDHL	55753	broad.mit.edu	37	chr10	50959004	50959004	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccaaaccgcttctctgaggaCcatttccgggccaggaagtc	10	14	1	1			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr10:50959004C>A	uc001jie.2	-	7	919	c.777G>T	c.(775-777)TGG>TGT	p.W259C	OGDHL_uc009xog.2_Missense_Mutation_p.W286C|OGDHL_uc010qgt.1_Missense_Mutation_p.W202C|OGDHL_uc010qgu.1_Missense_Mutation_p.W50C|OGDHL_uc009xoh.2_Missense_Mutation_p.W50C	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	259					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TCTCTGAGGACCATTTCCGGG	0.418													A	50959004	A	A	50959004	3	1	139	1	0	0	0	0	1	0	0	0	10840	508	18	5	2323	5	OGDHL	10	50959004	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08		50959004	84575743	20	9547											
CYSLTR2	57105	broad.mit.edu	37	chr13	49280992	49280992	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttgcaaccatccatctcCgtatcagaaatggaaccaaa	5	13	2	1			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr13:49280992C>T	uc010acx.1	+	6	722	c.39C>T	c.(37-39)TCC>TCT	p.S13S	CYSLTR2_uc010acy.1_Silent_p.S13S|CYSLTR2_uc010acz.1_Silent_p.S13S|CYSLTR2_uc010ada.1_Silent_p.S13S|CYSLTR2_uc010adb.1_Silent_p.S13S|CYSLTR2_uc010adc.1_Silent_p.S13S|CYSLTR2_uc010add.1_Silent_p.S13S|CYSLTR2_uc010acw.1_Silent_p.S13S|CYSLTR2_uc001vck.2_Silent_p.S13S	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	13	Extracellular (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	CATCCATCTCCGTATCAGAAA	0.373													T	49280992	T	T	49280992	2	4	139	1	0	0	0	0	0	0	0	1	4202	639	23	2		2	CYSLTR2	13	49280992	Silent	SNP	C	TCGA-14-1456-01B-01D-1494-08		49280992	65888886	21	9548											
SLC27A2	11001	broad.mit.edu	37	chr15	50515253	50515253	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atttgtcaagagatttggggAcatatgcatctatgagttct	10	5	3	2			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr15:50515253A>G	uc001zxw.2	+	5	1296	c.1064A>G	c.(1063-1065)GAC>GGC	p.D355G	SLC27A2_uc010bes.2_Missense_Mutation_p.D302G|SLC27A2_uc001zxx.2_Missense_Mutation_p.D120G	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	355	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		AGATTTGGGGACATATGCATC	0.428													G	50515253	G	G	50515253	3	3	139	1	0	0	0	0	1	0	0	0	14526	275	10	4	1082	4	SLC27A2	15	50515253	Missense_Mutation	SNP	A	TCGA-14-1456-01B-01D-1494-08		50515253	52016139	22	9549											
SEC11A	23478	broad.mit.edu	37	chr15	85234816	85234816	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagttattaccattaacccCttccagatcattagtgccga	5	13	1	1			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr15:85234816C>T	uc002blb.1	-	2	479	c.111G>A	c.(109-111)AAG>AAA	p.K37K	SEC11A_uc002blc.1_Silent_p.K11K	NM_014300	NP_055115	P67812	SC11A_HUMAN	SEC11-like 1	37	Lumenal (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	protein binding|serine-type peptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(143;0.199)			CCATTAACCCCTTCCAGATCA	0.408													T	85234816	T	T	85234816	2	4	139	1	0	0	0	0	0	0	0	1	13978	680	24	3		3	SEC11A	15	85234816	Silent	SNP	C	TCGA-14-1456-01B-01D-1494-08	34719563	85234816	17296576	23	9550											
C16orf54	283897	broad.mit.edu	37	chr16	29755735	29755735	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggggctcccaaactggaCgctggcctctggcctctgct	13	15	2	0			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr16:29755735C>T	uc002dtp.2	-	2	647	c.538G>A	c.(538-540)GTC>ATC	p.V180I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002dtq.1_5'Flank	NM_175900	NP_787096	Q6UWD8	CP054_HUMAN	hypothetical protein LOC283897	180						integral to membrane					0						CCAAACTGGACGCTGGCCTCT	0.711													T	29755735	T	T	29755735	3	4	139	1	0	0	0	0	1	0	0	0	1819	536	19	1	140	1	C16orf54	16	29755735	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08		29755735	60599018	24	9551											
PKD1L2	114780	broad.mit.edu	37	chr16	81211460	81211460	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtcccagggctgtggaggCgttgcagaagatggcaaagc	18	8	0	2			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr16:81211460C>T	uc002fgh.1	-	14	2389	c.2389G>A	c.(2389-2391)GCC>ACC	p.A797T	PKD1L2_uc002fgg.1_RNA|PKD1L2_uc002fgi.2_Missense_Mutation_p.A112T|PKD1L2_uc002fgj.2_Missense_Mutation_p.A797T|PKD1L2_uc002fgk.1_5'UTR|PKD1L2_uc002fgl.1_Intron	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	797	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCTGTGGAGGCGTTGCAGAAG	0.592													T	81211460	T	T	81211460	3	4	139	1	0	0	0	0	1	0	0	0	11965	768	27	1	5179	1	PKD1L2	16	81211460	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08	51455725	81211460	9143293	25	9552											
TP53	7157	broad.mit.edu	37	chr17	7578190	7578190	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accagacctcaggcggctcaTagggcaccaccacactatgt	9	15	2	1	rs121912666		TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr17:7578190T>C	uc002gim.2	-	6	853	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(205)|p.Y220N(12)|p.Y220H(9)|p.Y220S(9)|p.0?(7)|p.Y220fs*27(4)|p.Y220*(3)|p.Y220D(2)|p.Y127C(2)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*1(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578190	C	C	7578190	3	2	139	1	0	0	0	0	1	0	0	0	16378	1406	49	4	635	4	TP53	17	7578190	Missense_Mutation	SNP	T	TCGA-14-1456-01B-01D-1494-08		7578190	73617020	26	9553											
KCTD2	23510	broad.mit.edu	37	chr17	73043590	73043590	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgaacgtgggaggcacctActtcgtgaccaccagacaga	12	12	0	4			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr17:73043590A>G	uc002jmp.2	+	1	312	c.245A>G	c.(244-246)TAC>TGC	p.Y82C	KCTD2_uc010dfy.1_Intron|KCTD2_uc010dfz.2_Intron|ATP5H_uc002jmn.1_5'Flank|ATP5H_uc002jmo.1_5'Flank|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	82	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					GGAGGCACCTACTTCGTGACC	0.388													G	73043590	G	G	73043590	3	3	139	1	0	0	0	0	1	0	0	0	8107	391	14	4	247	4	KCTD2	17	73043590	Missense_Mutation	SNP	A	TCGA-14-1456-01B-01D-1494-08	65465400	73043590	8151620	27	9554											
CHD6	84181	broad.mit.edu	37	chr20	40049780	40049780	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaggtttcttttggagtcaCagacactaagactgcacata	8	9	2	2			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr20:40049780C>T	uc002xka.1	-	31	5673	c.5495G>A	c.(5494-5496)TGT>TAT	p.C1832Y		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1832					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTTGGAGTCACAGACACTAAG	0.383													T	40049780	T	T	40049780	3	4	139	1	0	0	0	0	1	0	0	0	3329	478	17	3	2680	3	CHD6	20	40049780	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08		40049780	22975740	28	9555											
PREX1	57580	broad.mit.edu	37	chr20	47267957	47267957	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcggtgaggccgaagcagcCgcggggctccacgatcttct	16	13	2	1			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chr20:47267957C>T	uc002xtw.1	-	22	2655	c.2632G>A	c.(2632-2634)GGC>AGC	p.G878S	PREX1_uc002xtv.1_Missense_Mutation_p.G175S	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	878					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCGAAGCAGCCGCGGGGCTCC	0.607													T	47267957	T	T	47267957	3	4	139	1	0	0	0	0	1	0	0	0	12476	652	23	2	2423	2	PREX1	20	47267957	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08	7218177	47267957	15757563	29	9556											
FOXR2	139628	broad.mit.edu	37	chrX	55650997	55650997	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gccgcttttgggaggagactCgtgtcttagcctttgctcaa	12	10	2	1			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chrX:55650997C>T	uc004duo.2	+	1	1165	c.853C>T	c.(853-855)CGT>TGT	p.R285C		NM_198451	NP_940853	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	285	Fork-head.				embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			lung(2)|central_nervous_system(1)	3						GGAGGAGACTCGTGTCTTAGC	0.502													T	55650997	T	T	55650997	3	4	139	1	0	0	0	0	1	0	0	0	6032	884	31	2	855	2	FOXR2	23	55650997	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08		55650997	99619563	30	9557											
ATRX	546	broad.mit.edu	37	chrX	76872118	76872118	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tagtactgatagagcttgcaCtgaatagaagtcattctcac	8	8	2	4			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chrX:76872118C>G	uc004ecp.3	-	22	5761	c.5529G>C	c.(5527-5529)CAG>CAC	p.Q1843H	ATRX_uc004ecq.3_Missense_Mutation_p.Q1805H|ATRX_uc004eco.3_Missense_Mutation_p.Q1628H	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1843					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AGAGCTTGCACTGAATAGAAG	0.328			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						G	76872118	G	G	76872118	3	3	139	1	0	0	0	0	1	0	0	0	1208	564	20	5	2005	5	ATRX	23	76872118	Missense_Mutation	SNP	C	TCGA-14-1456-01B-01D-1494-08	21221121	76872118	78398442	31	9558											
TBX22	50945	broad.mit.edu	37	chrX	79282295	79282295	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcccagattcagtccttgccCactgaaggtgttaaaacatt	7	11	1	2			TCGA-14-1456-01B-01D-1494-08	TCGA-14-1456-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	e525e774-f925-41cd-9822-15aeeee29190	e8f3b57f-a7f3-4086-8319-fa7d0761eb85	g.chrX:79282295C>A	uc010nmg.1	+	6	860	c.726C>A	c.(724-726)CCC>CCA	p.P242P	TBX22_uc004edi.1_Silent_p.P122P|TBX22_uc004edj.1_Silent_p.P242P	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	242	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						AGTCCTTGCCCACTGAAGGTG	0.463													A	79282295	A	A	79282295	2	1	139	1	0	0	0	0	0	0	0	1	15655	581	21	5		5	TBX22	23	79282295	Silent	SNP	C	TCGA-14-1456-01B-01D-1494-08	2410177	79282295	75988265	32	9559											
LOC440563	440563	broad.mit.edu	37	chr1	13183032	13183032	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtgctgtctctgttatcctCtccttcctcagcatcttttt	6	13	4	0	rs55971446	by1000genomes	TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr1:13183032C>T	uc010obg.1	-	1	936	c.841G>A	c.(841-843)GAG>AAG	p.E281K		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	281						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CTGTTATCCTCTCCTTCCTCA	0.443													T	13183032	T	T	13183032	3	4	140	1	0	0	0	0	1	0	0	0	8879	922	32	3	44	3	LOC440563	1	13183032	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08		13183032	236067589	1	9560											
PADI6	353238	broad.mit.edu	37	chr1	17721458	17721458	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccttctagcgcagagggccGggccatgagtaagaccctcc	12	14	1	3			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr1:17721458G>A	uc001bak.1	+	13	1349	c.1349G>A	c.(1348-1350)CGG>CAG	p.R450Q		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	442					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GCAGAGGGCCGGGCCATGAGT	0.602													A	17721458	A	A	17721458	3	1	140	1	0	0	0	0	1	0	0	0	11381	1116	39	2	1396	2	PADI6	1	17721458	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	4538426	17721458	231529163	2	9561											
KIAA0090	23065	broad.mit.edu	37	chr1	19546124	19546124	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcgcattcgagaaactgtcTggttatagttgatgaatcgc	10	8	1	3			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr1:19546124T>C	uc001bbo.2	-	22	2784	c.2741A>G	c.(2740-2742)CAG>CGG	p.Q914R	KIAA0090_uc001bbn.2_RNA|KIAA0090_uc001bbp.2_Missense_Mutation_p.Q913R|KIAA0090_uc001bbq.2_Missense_Mutation_p.Q913R|KIAA0090_uc001bbr.2_Missense_Mutation_p.Q892R	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	914	DUF1620.|Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		AGAAACTGTCTGGTTATAGTT	0.507													C	19546124	C	C	19546124	3	2	140	1	0	0	0	0	1	0	0	0	8153	1580	55	4	248	4	KIAA0090	1	19546124	Missense_Mutation	SNP	T	TCGA-14-1823-01A-01W-0643-08	1824666	19546124	229704497	3	9562											
KIF17	57576	broad.mit.edu	37	chr1	20992723	20992723	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcactgaggctcttcctggcGtctgtgctgaggatctggct	13	11	4	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr1:20992723G>A	uc001bdr.3	-	14	3013	c.2895C>T	c.(2893-2895)GAC>GAT	p.D965D	KIF17_uc001bdp.3_Silent_p.D242D|KIF17_uc001bdq.3_Silent_p.D243D|KIF17_uc009vpx.2_Silent_p.D335D|KIF17_uc001bds.3_Silent_p.D964D	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	965					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TCTTCCTGGCGTCTGTGCTGA	0.517													A	20992723	A	A	20992723	2	1	140	1	0	0	0	0	0	0	0	1	8279	1136	40	1		1	KIF17	1	20992723	Silent	SNP	G	TCGA-14-1823-01A-01W-0643-08	1446599	20992723	228257898	4	9563											
NR0B2	8431	broad.mit.edu	37	chr1	27240176	27240176	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagcaaccctgcagcagccGccgctggtcctggggaggca	14	16	0	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr1:27240176G>A	uc001bnf.2	-	1	392	c.256C>T	c.(256-258)CGG>TGG	p.R86W		NM_021969	NP_068804	Q15466	NR0B2_HUMAN	short heterodimer partner	86	Ligand-binding (By similarity).				cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		TGCAGCAGCCGCCGCTGGTCC	0.642													A	27240176	A	A	27240176	3	1	140	1	0	0	0	0	1	0	0	0	10614	1086	38	1	525	1	NR0B2	1	27240176	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	6247453	27240176	222010445	5	9564											
TNR	7143	broad.mit.edu	37	chr1	175372637	175372637	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccggctggagcaacccagCgggcagtagggctccgagca	15	15	0	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr1:175372637C>T	uc001gkp.1	-	2	696	c.615G>A	c.(613-615)CCG>CCA	p.P205P	TNR_uc009wwu.1_Silent_p.P205P|TNR_uc010pmz.1_Silent_p.P205P	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	205	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AGCAACCCAGCGGGCAGTAGG	0.597													T	175372637	T	T	175372637	2	4	140	1	0	0	0	0	0	0	0	1	16335	755	27	1		1	TNR	1	175372637	Silent	SNP	C	TCGA-14-1823-01A-01W-0643-08	148132461	175372637	73877984	6	9565											
CFHR4	10877	broad.mit.edu	37	chr1	196871608	196871608	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctatattataagagtttgcGtagactatactttccagcag	7	7	1	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr1:196871608G>A	uc001gto.2	+	2	188	c.119G>A	c.(118-120)CGT>CAT	p.R40H	CFHR4_uc009wyy.2_Missense_Mutation_p.R39H|CFHR4_uc001gtp.2_Missense_Mutation_p.R40H	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	40	Sushi 1.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						AAGAGTTTGCGTAGACTATAC	0.323													A	196871608	A	A	196871608	3	1	140	1	0	0	0	0	1	0	0	0	3287	1145	40	1	125	1	CFHR4	1	196871608	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	21498971	196871608	52379013	7	9566											
RGPD3	653489	broad.mit.edu	37	chr2	107049596	107049596	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttggtgatagtgaatatttgGtaggagatggtgtagaatgt	15	0	0	4			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr2:107049596G>C	uc010ywi.1	-	16	2408	c.2351C>G	c.(2350-2352)ACC>AGC	p.T784S		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	784					intracellular transport		binding			ovary(1)	1						TGAATATTTGGTAGGAGATGG	0.338													C	107049596	C	C	107049596	3	2	140	1	0	0	0	0	1	0	0	0	13287	1261	44	5	2957	5	RGPD3	2	107049596	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08		107049596	136149777	8	9567											
CNTNAP5	129684	broad.mit.edu	37	chr2	125405459	125405459	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcatggaacagctggaggcCgtgatcgacggctctgagca	15	10	1	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr2:125405459C>T	uc002tno.2	+	13	2362	c.1998C>T	c.(1996-1998)GCC>GCT	p.A666A	CNTNAP5_uc010flu.2_Silent_p.A667A	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	666	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AGCTGGAGGCCGTGATCGACG	0.622													T	125405459	T	T	125405459	2	4	140	1	0	0	0	0	0	0	0	1	3650	639	23	2		2	CNTNAP5	2	125405459	Silent	SNP	C	TCGA-14-1823-01A-01W-0643-08	18355863	125405459	117793914	9	9568											
THSD7B	80731	broad.mit.edu	37	chr2	138033556	138033556	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgtctggcagggaataacGggcagcagtgaagcctgtgg	16	8	2	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr2:138033556G>A	uc002tva.1	+	11	2367	c.2367G>A	c.(2365-2367)ACG>ACA	p.T789T	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.T679T	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AGGGAATAACGGGCAGCAGTG	0.398													A	138033556	A	A	138033556	2	1	140	1	0	0	0	0	0	0	0	1	15877	1103	39	2		2	THSD7B	2	138033556	Silent	SNP	G	TCGA-14-1823-01A-01W-0643-08	12628097	138033556	105165817	10	9569											
NEB	4703	broad.mit.edu	37	chr2	152425820	152425820	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcatgtttggcatgattgaCggacacggagtcatttggca	14	7	1	2	rs149881695	by1000genomes	TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr2:152425820C>T	uc010fnx.2	-	82	12585	c.12394G>A	c.(12394-12396)GTC>ATC	p.V4132I	NEB_uc002txr.2_Missense_Mutation_p.V555I	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4132	Nebulin 113.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCATGATTGACGGACACGGAG	0.458													T	152425820	T	T	152425820	3	4	140	1	0	0	0	0	1	0	0	0	10302	536	19	1	8481	1	NEB	2	152425820	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	14392264	152425820	90773553	11	9570											
COBLL1	22837	broad.mit.edu	37	chr2	165551266	165551266	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggcagctgcagatgtcacaTagtgacccgatactctcttc	9	12	2	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr2:165551266T>C	uc010zcw.1	-	15	3075	c.2951A>G	c.(2950-2952)TAT>TGT	p.Y984C	COBLL1_uc002ucp.2_Missense_Mutation_p.Y917C|COBLL1_uc002ucq.2_Missense_Mutation_p.Y879C|COBLL1_uc010zcx.1_Missense_Mutation_p.Y925C|COBLL1_uc002ucn.2_Missense_Mutation_p.Y345C|COBLL1_uc002uco.2_Missense_Mutation_p.Y648C	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	955										ovary(2)|pancreas(1)	3						AGATGTCACATAGTGACCCGA	0.448													C	165551266	C	C	165551266	3	2	140	1	0	0	0	0	1	0	0	0	3654	1406	49	4	762	4	COBLL1	2	165551266	Missense_Mutation	SNP	T	TCGA-14-1823-01A-01W-0643-08	13125446	165551266	77648107	12	9571											
TTN	7273	broad.mit.edu	37	chr2	179454479	179454479	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttaatagccagaatgggaGtttttgtttcgatggttggc	14	4	0	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr2:179454479G>A	uc010zfg.1	-	253	54493	c.54269C>T	c.(54268-54270)ACT>ATT	p.T18090I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T11785I|TTN_uc010zfi.1_Missense_Mutation_p.T11718I|TTN_uc010zfj.1_Missense_Mutation_p.T11593I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19017							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAATGGGAGTTTTTGTTTC	0.413													A	179454479	A	A	179454479	3	1	140	1	0	0	0	0	1	0	0	0	16732	1029	36	3	46242	3	TTN	2	179454479	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	13903213	179454479	63744894	13	9572											
CCDC141	285025	broad.mit.edu	37	chr2	179730518	179730518	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttatctcgtctctcatggcGcagtactccacactacggga	8	13	3	0	rs144206841		TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr2:179730518G>A	uc002unf.1	-	7	1032	c.975C>T	c.(973-975)TGC>TGT	p.C325C		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	325	Potential.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CTCTCATGGCGCAGTACTCCA	0.532													A	179730518	A	A	179730518	2	1	140	1	0	0	0	0	0	0	0	1	2775	1079	38	1		1	CCDC141	2	179730518	Silent	SNP	G	TCGA-14-1823-01A-01W-0643-08	276039	179730518	63468855	14	9573											
NEU2	4759	broad.mit.edu	37	chr2	233899574	233899574	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcaacccgcgacctccagCccctgaggcctggtcagagc	10	19	2	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr2:233899574C>T	uc010zmn.1	+	2	950	c.950C>T	c.(949-951)GCC>GTC	p.A317V		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	317							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CGACCTCCAGCCCCTGAGGCC	0.672													T	233899574	T	T	233899574	3	4	140	1	0	0	0	0	1	0	0	0	10342	739	26	3	956	3	NEU2	2	233899574	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	54169056	233899574	9299799	15	9574											
ANO7	50636	broad.mit.edu	37	chr2	242149970	242149970	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctatgtatccctggcccacGtcctgacacgatggggtgag	12	12	1	2	rs148576854		TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr2:242149970G>A	uc002wax.2	+	15	1811	c.1708G>A	c.(1708-1710)GTC>ATC	p.V570I		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	570	Helical; (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CCTGGCCCACGTCCTGACACG	0.622													A	242149970	A	A	242149970	3	1	140	1	0	0	0	0	1	0	0	0	702	1145	40	1	1838	1	ANO7	2	242149970	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	8250396	242149970	1049403	16	9575											
OGG1	4968	broad.mit.edu	37	chr3	9798237	9798237	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgtggcacattgcccaacGtgactacagctggcacccta	9	13	0	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr3:9798237G>A	uc003bsi.2	+	5	1173	c.830G>A	c.(829-831)CGT>CAT	p.R277H	OGG1_uc003bsh.2_Missense_Mutation_p.R277H|OGG1_uc003bsj.2_Missense_Mutation_p.R277H|OGG1_uc003bsk.2_Missense_Mutation_p.R277H|OGG1_uc003bsl.2_Missense_Mutation_p.R277H|OGG1_uc003bsm.2_Missense_Mutation_p.R277H|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|OGG1_uc003bsp.1_Missense_Mutation_p.R42H|OGG1_uc010hcm.1_Intron|OGG1_uc003bsq.1_Intron|OGG1_uc003bsr.1_Missense_Mutation_p.R42H	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	277					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					ATTGCCCAACGTGACTACAGC	0.602								BER_DNA_glycosylases					A	9798237	A	A	9798237	3	1	140	1	0	0	0	0	1	0	0	0	10845	1145	40	1	848	1	OGG1	3	9798237	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08		9798237	188224193	17	9576											
NKIRAS1	28512	broad.mit.edu	37	chr3	23942514	23942514	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tactgaagccatgtatacatCttccattgtttcgcaatctt	5	10	2	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr3:23942514C>A	uc003ccj.2	-	4	523	c.121G>T	c.(121-123)GAT>TAT	p.D41Y	NKIRAS1_uc003cck.2_Missense_Mutation_p.D41Y|NKIRAS1_uc003ccl.2_Missense_Mutation_p.D41Y|NKIRAS1_uc003ccm.2_Missense_Mutation_p.D41Y	NM_020345	NP_065078	Q9NYS0	KBRS1_HUMAN	kappa B-ras 1	41	Effector region.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity				0						ATGTATACATCTTCCATTGTT	0.413													A	23942514	A	A	23942514	3	1	140	1	0	0	0	0	1	0	0	0	10444	913	32	5	465	5	NKIRAS1	3	23942514	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	14144277	23942514	174079916	18	9577											
ACTR8	93973	broad.mit.edu	37	chr3	53909976	53909976	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caccttccaagttccttaccGagtattccgatgagacaccc	6	15	0	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr3:53909976G>A	uc003dhd.2	-	7	969	c.910C>T	c.(910-912)CGG>TGG	p.R304W	ACTR8_uc003dhb.2_Missense_Mutation_p.R54C|ACTR8_uc003dhc.2_Missense_Mutation_p.R193W	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	304					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		GTTCCTTACCGAGTATTCCGA	0.433													A	53909976	A	A	53909976	3	1	140	1	0	0	0	0	1	0	0	0	217	1072	37	2	992	2	ACTR8	3	53909976	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	29967462	53909976	144112454	19	9578											
EPHA6	285220	broad.mit.edu	37	chr3	97167503	97167503	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agccaccaaatatgtatttcAcatccgagtgagaactgcga	8	10	1	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr3:97167503A>T	uc010how.1	+	7	1866	c.1823A>T	c.(1822-1824)CAC>CTC	p.H608L	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_5'UTR|EPHA6_uc003drs.3_5'UTR|EPHA6_uc003drr.3_5'UTR|EPHA6_uc003drt.2_5'UTR|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	513	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TATGTATTTCACATCCGAGTG	0.448													T	97167503	T	T	97167503	3	4	140	1	0	0	0	0	1	0	0	0	5171	159	6	5	1849	5	EPHA6	3	97167503	Missense_Mutation	SNP	A	TCGA-14-1823-01A-01W-0643-08	43257527	97167503	100854927	20	9579											
MORC1	27136	broad.mit.edu	37	chr3	108698509	108698509	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catcttccatcggcacattgAgcaagctgaggtttgtcatt	9	10	2	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr3:108698509A>T	uc003dxl.2	-	24	2417	c.2330T>A	c.(2329-2331)CTC>CAC	p.L777H	MORC1_uc011bhn.1_Missense_Mutation_p.L756H	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	777					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CGGCACATTGAGCAAGCTGAG	0.368													T	108698509	T	T	108698509	3	4	140	1	0	0	0	0	1	0	0	0	9701	304	11	5	644	5	MORC1	3	108698509	Missense_Mutation	SNP	A	TCGA-14-1823-01A-01W-0643-08	11531006	108698509	89323921	21	9580											
UGT2A3	79799	broad.mit.edu	37	chr4	69796959	69796959	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcctttgtacctccataacAcctacggaagaaacacatgt	5	12	0	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr4:69796959A>C	uc003hef.2	-	4	1029	c.998T>G	c.(997-999)GTG>GGG	p.V333G	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	333	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CCTCCATAACACCTACGGAAG	0.373													C	69796959	C	C	69796959	3	2	140	1	0	0	0	0	1	0	0	0	16952	173	6	5	597	5	UGT2A3	4	69796959	Missense_Mutation	SNP	A	TCGA-14-1823-01A-01W-0643-08		69796959	121357317	22	9581											
DDX60	55601	broad.mit.edu	37	chr4	169196591	169196591	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	catgtattgcagttggaaccGagctggcccaatgccaactg	11	11	0	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr4:169196591G>A	uc003irp.2	-	16	2501	c.2209C>T	c.(2209-2211)CGG>TGG	p.R737W		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	737							ATP binding|ATP-dependent helicase activity|RNA binding	p.R737W(2)		ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AGTTGGAACCGAGCTGGCCCA	0.393													A	169196591	A	A	169196591	3	1	140	1	0	0	0	0	1	0	0	0	4378	1057	37	2	3021	2	DDX60	4	169196591	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	99399632	169196591	21957685	23	9582											
KCNQ5	56479	broad.mit.edu	37	chr6	73713705	73713705	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcacacaaaattggcctcaaGttgcctcttgatcctggtaa	8	11	2	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr6:73713705G>T	uc003pgk.2	+	2	820	c.473G>T	c.(472-474)AGT>ATT	p.S158I	KCNQ5_uc003pgj.3_Missense_Mutation_p.S158I|KCNQ5_uc011dyh.1_Missense_Mutation_p.S158I|KCNQ5_uc011dyi.1_Missense_Mutation_p.S158I|KCNQ5_uc010kat.2_Missense_Mutation_p.S158I|KCNQ5_uc011dyj.1_Missense_Mutation_p.S158I|KCNQ5_uc011dyk.1_5'UTR	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	158	Helical; Name=Segment S2; (Potential).				protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TTGGCCTCAAGTTGCCTCTTG	0.358													T	73713705	T	T	73713705	3	4	140	1	0	0	0	0	1	0	0	0	8086	1029	36	5	479	5	KCNQ5	6	73713705	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08		73713705	97401362	24	9583											
COL12A1	1303	broad.mit.edu	37	chr6	75858174	75858174	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctctaaaagaacgatgggttCgctcagaaataactaagtta	8	7	2	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr6:75858174C>T	uc003phs.2	-	22	4353	c.4187G>A	c.(4186-4188)CGA>CAA	p.R1396Q	COL12A1_uc003pht.2_Missense_Mutation_p.R232Q	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1396	Fibronectin type-III 9.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						ACGATGGGTTCGCTCAGAAAT	0.398													T	75858174	T	T	75858174	3	4	140	1	0	0	0	0	1	0	0	0	3669	884	31	2	5184	2	COL12A1	6	75858174	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	2144469	75858174	95256893	25	9584											
BVES	11149	broad.mit.edu	37	chr6	105573416	105573416	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacggagtggttcaaacaatCgccggtacatgccactgagt	11	11	1	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr6:105573416C>T	uc003pqw.2	-	4	546	c.389G>A	c.(388-390)CGA>CAA	p.R130Q	BVES_uc003pqx.2_Missense_Mutation_p.R130Q|BVES_uc003pqy.2_Missense_Mutation_p.R130Q	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	130	Cytoplasmic (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				TTCAAACAATCGCCGGTACAT	0.443													T	105573416	T	T	105573416	3	4	140	1	0	0	0	0	1	0	0	0	1575	884	31	2	713	2	BVES	6	105573416	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	29715242	105573416	65541651	26	9585											
T	6862	broad.mit.edu	37	chr6	166571970	166571970	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgaggggtgtgtagtgcgCgggggagccccggaagaact	21	7	0	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr6:166571970C>T	uc003quu.1	-	9	1634	c.1141G>A	c.(1141-1143)GCG>ACG	p.A381T	T_uc003qut.1_Missense_Mutation_p.A382T|T_uc003quv.1_Missense_Mutation_p.A323T	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	381					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GTGTAGTGCGCGGGGGAGCCC	0.711									Chordoma_Familial_Clustering_of				T	166571970	T	T	166571970	3	4	140	1	0	0	0	0	1	0	0	0	15485	768	27	1	170	1	T	6	166571970	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	60998554	166571970	4543097	27	9586											
FERD3L	222894	broad.mit.edu	37	chr7	19184907	19184907	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagtcgcagaggagagggcGtctcggggaggccagggaca	20	8	1	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr7:19184907G>A	uc003suo.1	-	1	138	c.79C>T	c.(79-81)CGC>TGC	p.R27C	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	27					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						AGGAGAGGGCGTCTCGGGGAG	0.652													A	19184907	A	A	19184907	3	1	140	1	0	0	0	0	1	0	0	0	5816	1145	40	1	425	1	FERD3L	7	19184907	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08		19184907	139953756	28	9587											
UPP1	7378	broad.mit.edu	37	chr7	48139333	48139333	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gaagatattctctatcatttCaatctcaccactagcagaca	4	11	4	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr7:48139333C>A	uc003toj.2	+	5	640	c.111C>A	c.(109-111)TTC>TTA	p.F37L	UPP1_uc003tok.2_Missense_Mutation_p.F37L|UPP1_uc003tol.2_Missense_Mutation_p.F37L|UPP1_uc011kcg.1_Missense_Mutation_p.F37L|UPP1_uc011kch.1_Intron|UPP1_uc003ton.2_Intron|UPP1_uc003too.2_Intron	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	37					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						TCTATCATTTCAATCTCACCA	0.393													A	48139333	A	A	48139333	3	1	140	1	0	0	0	0	1	0	0	0	17009	825	29	5	117	5	UPP1	7	48139333	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	28954426	48139333	110999330	29	9588											
UPP1	7378	broad.mit.edu	37	chr7	48146585	48146585	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cggaaaacggaccttaacaaGaagctggtgcaggagctgtt	13	8	0	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr7:48146585G>T	uc003toj.2	+	8	1081	c.552G>T	c.(550-552)AAG>AAT	p.K184N	UPP1_uc003tok.2_Missense_Mutation_p.K184N|UPP1_uc003tol.2_Missense_Mutation_p.K184N|UPP1_uc011kch.1_5'UTR|UPP1_uc003ton.2_Missense_Mutation_p.K47N|UPP1_uc003too.2_Missense_Mutation_p.K47N	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	184					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						ACCTTAACAAGAAGCTGGTGC	0.537													T	48146585	T	T	48146585	3	4	140	1	0	0	0	0	1	0	0	0	17009	933	33	5	570	5	UPP1	7	48146585	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	7252	48146585	110992078	30	9589											
EGFR	1956	broad.mit.edu	37	chr7	55221821	55221821	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggcaaatacagctttggtGccacctgcgtgaagaagtgt	13	8	0	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr7:55221821G>A	uc003tqk.2	+	7	1111	c.865G>A	c.(865-867)GCC>ACC	p.A289T	EGFR_uc003tqh.2_Missense_Mutation_p.A289T|EGFR_uc003tqi.2_Missense_Mutation_p.A289T|EGFR_uc003tqj.2_Missense_Mutation_p.A289T|EGFR_uc010kzg.1_Missense_Mutation_p.A244T|EGFR_uc011kco.1_Missense_Mutation_p.A236T|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTTTGGTGCCACCTGCGT	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55221821	A	A	55221821	3	1	140	1	0	0	0	0	1	0	0	0	4967	1319	46	3	891	3	EGFR	7	55221821	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	7075236	55221821	103916842	31	9590											
FZD1	8321	broad.mit.edu	37	chr7	90894669	90894669	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cagttctaccctctagtgaaAgtgcagtgttccgctgagct	10	11	2	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr7:90894669A>T	uc003ula.2	+	1	887	c.474A>T	c.(472-474)AAA>AAT	p.K158N		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	158	FZ.|Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CTCTAGTGAAAGTGCAGTGTT	0.632													T	90894669	T	T	90894669	3	4	140	1	0	0	0	0	1	0	0	0	6128	69	3	5	476	5	FZD1	7	90894669	Missense_Mutation	SNP	A	TCGA-14-1823-01A-01W-0643-08	35672848	90894669	68243994	32	9591											
MUC17	140453	broad.mit.edu	37	chr7	100685376	100685376	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agccagttcatctccagcaaCtcttcaggtcaccactatgc	6	15	5	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr7:100685376C>G	uc003uxp.1	+	3	10732	c.10679C>G	c.(10678-10680)ACT>AGT	p.T3560S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3560	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCTCCAGCAACTCTTCAGGTC	0.478													G	100685376	G	G	100685376	3	3	140	1	0	0	0	0	1	0	0	0	9974	565	20	5	10689	5	MUC17	7	100685376	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	9790707	100685376	58453287	33	9592											
DGKI	9162	broad.mit.edu	37	chr7	137263039	137263039	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgcatagaacattttatttcGaaaacgactgttgaatttct	6	6	1	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr7:137263039G>A	uc003vtt.2	-	16	1676	c.1675C>T	c.(1675-1677)CGA>TGA	p.R559*	DGKI_uc003vtu.2_Nonsense_Mutation_p.R259*	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	559					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						ATTTTATTTCGAAAACGACTG	0.338													A	137263039	A	A	137263039	4	1	140	1	0	0	0	0	0	1	0	0	4471	1066	37	2	1598	2	DGKI	7	137263039	Nonsense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	36577663	137263039	21875624	34	9593											
PSD3	23362	broad.mit.edu	37	chr8	18432725	18432725	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtccgtggccttggatgccAatgcgtggtgcacactcaca	12	12	1	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr8:18432725A>G	uc003wza.2	-	13	2655	c.2552T>C	c.(2551-2553)TTG>TCG	p.L851S	PSD3_uc003wyx.3_Missense_Mutation_p.L180S|PSD3_uc003wyy.2_Missense_Mutation_p.L317S|PSD3_uc003wyz.2_Missense_Mutation_p.L152S	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	852	PH.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTTGGATGCCAATGCGTGGTG	0.428													G	18432725	G	G	18432725	3	3	140	1	0	0	0	0	1	0	0	0	12648	131	5	4	607	4	PSD3	8	18432725	Missense_Mutation	SNP	A	TCGA-14-1823-01A-01W-0643-08		18432725	127931297	35	9594											
LGI3	203190	broad.mit.edu	37	chr8	22006477	22006477	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accaccatcggcttgcagtgCactgcagagggggctgtgcc	14	13	0	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr8:22006477C>A	uc003xav.2	-	8	1132	c.843G>T	c.(841-843)GTG>GTT	p.V281V	LGI3_uc010ltu.2_Silent_p.V257V	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	281	EAR 2.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		GCTTGCAGTGCACTGCAGAGG	0.627													A	22006477	A	A	22006477	2	1	140	1	0	0	0	0	0	0	0	1	8753	697	25	5		5	LGI3	8	22006477	Silent	SNP	C	TCGA-14-1823-01A-01W-0643-08	3573752	22006477	124357545	36	9595											
SNAI2	6591	broad.mit.edu	37	chr8	49831516	49831516	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacctgtctgcaaatgctctGttgcagtgagggcaagaaaa	12	8	2	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr8:49831516G>T	uc003xqp.2	-	3	821	c.657C>A	c.(655-657)AAC>AAA	p.N219K		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	219	C2H2-type 4.				canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				CAAATGCTCTGTTGCAGTGAG	0.433													T	49831516	T	T	49831516	3	4	140	1	0	0	0	0	1	0	0	0	14827	1368	48	5	153	5	SNAI2	8	49831516	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	27825039	49831516	96532506	37	9596											
ZFHX4	79776	broad.mit.edu	37	chr8	77763369	77763369	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgctgtaaccattgtagcttGgctttcaaaactatgcagaa	8	9	1	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr8:77763369G>C	uc003yav.2	+	10	4464	c.4077G>C	c.(4075-4077)TTG>TTC	p.L1359F	ZFHX4_uc003yau.1_Missense_Mutation_p.L1404F|ZFHX4_uc003yaw.1_Missense_Mutation_p.L1359F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1359	C2H2-type 10.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATTGTAGCTTGGCTTTCAAAA	0.453										HNSCC(33;0.089)			C	77763369	C	C	77763369	3	2	140	1	0	0	0	0	1	0	0	0	17632	1339	47	5	4246	5	ZFHX4	8	77763369	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	27931853	77763369	68600653	38	9597											
LRP12	29967	broad.mit.edu	37	chr8	105503293	105503293	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccctgagtcatacgactgaGtgcacttgtaagctggtgac	11	11	1	3			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr8:105503293G>C	uc003yma.2	-	7	2283	c.2188C>G	c.(2188-2190)CTC>GTC	p.L730V	LRP12_uc003ymb.2_Missense_Mutation_p.L711V|LRP12_uc003ylz.2_Missense_Mutation_p.L136V	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	730	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATACGACTGAGTGCACTTGTA	0.493													C	105503293	C	C	105503293	3	2	140	1	0	0	0	0	1	0	0	0	8954	1029	36	5	395	5	LRP12	8	105503293	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	27739924	105503293	40860729	39	9598											
NFX1	4799	broad.mit.edu	37	chr9	33351731	33351731	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagctgactgtggtcacccGtgtatggcaccctgccatac	11	13	1	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr9:33351731G>A	uc003zsq.2	+	16	2659	c.2598G>A	c.(2596-2598)CCG>CCA	p.P866P	SUGT1P1_uc010mjq.1_Intron|NFX1_uc003zsp.1_Silent_p.P866P|NFX1_uc010mjr.1_Silent_p.P867P|NFX1_uc003zsr.2_Silent_p.P867P	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	866	NF-X1-type 8.				inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		GTGGTCACCCGTGTATGGCAC	0.552													A	33351731	A	A	33351731	2	1	140	1	0	0	0	0	0	0	0	1	10387	1132	40	1		1	NFX1	9	33351731	Silent	SNP	G	TCGA-14-1823-01A-01W-0643-08		33351731	107861700	40	9599											
VPS13A	23230	broad.mit.edu	37	chr9	79867155	79867155	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tattttctgtacttaggtgaTaattggagagaagcacgaaa	10	4	1	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr9:79867155T>C	uc004akr.2	+	22	2435	c.2175T>C	c.(2173-2175)GAT>GAC	p.D725D	VPS13A_uc004akp.3_Silent_p.D725D|VPS13A_uc004akq.3_Silent_p.D725D|VPS13A_uc004aks.2_Silent_p.D725D	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	725					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						ACTTAGGTGATAATTGGAGAG	0.343													C	79867155	C	C	79867155	2	2	140	1	0	0	0	0	0	0	0	1	17186	1403	49	4		4	VPS13A	9	79867155	Silent	SNP	T	TCGA-14-1823-01A-01W-0643-08	46515424	79867155	61346276	41	9600											
C9orf125	84302	broad.mit.edu	37	chr9	104239089	104239089	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagccagggccggggggtggCctgccagacaatgggcactg	18	12	0	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr9:104239089C>A	uc004bbm.2	-	2	608	c.286G>T	c.(286-288)GCC>TCC	p.A96S	uc004bbl.1_5'Flank	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	hypothetical protein LOC84302	96						integral to membrane					0		Acute lymphoblastic leukemia(62;0.0527)				CGGGGGGTGGCCTGCCAGACA	0.592													A	104239089	A	A	104239089	3	1	140	1	0	0	0	0	1	0	0	0	2454	739	26	5	929	5	C9orf125	9	104239089	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	24371934	104239089	36974342	42	9601											
NUP214	8021	broad.mit.edu	37	chr9	134022964	134022964	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tccagcggcaaagccaggctCtccccaggtatgtttaaatt	9	12	1	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr9:134022964C>G	uc004cag.2	+	14	2144	c.2033C>G	c.(2032-2034)TCT>TGT	p.S678C	NUP214_uc004cah.2_Missense_Mutation_p.S668C|NUP214_uc004cai.2_Missense_Mutation_p.S108C|NUP214_uc004caf.1_Missense_Mutation_p.S667C|NUP214_uc010mzf.2_Intron	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	678	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		AAGCCAGGCTCTCCCCAGGTA	0.433			T	DEK|SET|ABL1	AML|T-ALL								G	134022964	G	G	134022964	3	3	140	1	0	0	0	0	1	0	0	0	10762	913	32	5	2087	5	NUP214	9	134022964	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	29783875	134022964	7190467	43	9602											
NAALADL1	10004	broad.mit.edu	37	chr11	64825878	64825878	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccaggatctccaggtccaggTcctggggggccagtgagttg	16	11	1	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr11:64825878T>A	uc001ocn.2	-	1	132	c.116A>T	c.(115-117)GAC>GTC	p.D39V	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	39	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						CAGGTCCAGGTCCTGGGGGGC	0.637													A	64825878	A	A	64825878	3	1	140	1	0	0	0	0	1	0	0	0	10129	1667	58	5	2178	5	NAALADL1	11	64825878	Missense_Mutation	SNP	T	TCGA-14-1823-01A-01W-0643-08		64825878	70180638	44	9603											
SART1	9092	broad.mit.edu	37	chr11	65743897	65743897	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgaagaagctggagtctcGccagcggggctgggaggagg	20	7	1	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr11:65743897G>A	uc001ogl.2	+	13	1696	c.1604G>A	c.(1603-1605)CGC>CAC	p.R535H		NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	535					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1						CTGGAGTCTCGCCAGCGGGGC	0.637													A	65743897	A	A	65743897	3	1	140	1	0	0	0	0	1	0	0	0	13846	1087	38	1	1654	1	SART1	11	65743897	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	918019	65743897	69262619	45	9604											
SLC38A1	81539	broad.mit.edu	37	chr12	46594885	46594885	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agtagaaattacttaccataGaatgtcaagtagccaaaaat	6	6	1	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr12:46594885G>C	uc001rpa.2	-	13	1257	c.999C>G	c.(997-999)TTC>TTG	p.F333L	SLC38A1_uc001rpb.2_Missense_Mutation_p.F333L|SLC38A1_uc001rpc.2_Missense_Mutation_p.F333L|SLC38A1_uc001rpd.2_Missense_Mutation_p.F333L|SLC38A1_uc001rpe.2_Missense_Mutation_p.F333L|SLC38A1_uc010slh.1_Missense_Mutation_p.F306L|SLC38A1_uc009zkj.1_Missense_Mutation_p.F333L	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	333	Helical; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			ACTTACCATAGAATGTCAAGT	0.299													C	46594885	C	C	46594885	3	2	140	1	0	0	0	0	1	0	0	0	14601	933	33	5	484	5	SLC38A1	12	46594885	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08		46594885	87257010	46	9605											
OR6C6	283365	broad.mit.edu	37	chr12	55688832	55688832	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttccaaaaaggagaaattaCggagaaagaaatacattggc	9	6	0	3			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr12:55688832C>T	uc010sph.1	-	1	185	c.185G>A	c.(184-186)CGT>CAT	p.R62H		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	62	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						GGAGAAATTACGGAGAAAGAA	0.388													T	55688832	T	T	55688832	3	4	140	1	0	0	0	0	1	0	0	0	11194	536	19	1	761	1	OR6C6	12	55688832	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	9093947	55688832	78163063	47	9606											
APPL2	55198	broad.mit.edu	37	chr12	105600948	105600948	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggagaggtgctgcttccgcCgggccgcggccacctctttt	14	14	1	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr12:105600948C>T	uc001tlf.1	-	8	730	c.512G>A	c.(511-513)CGG>CAG	p.R171Q	APPL2_uc010swt.1_Missense_Mutation_p.R128Q|APPL2_uc001tlg.1_5'UTR|APPL2_uc010swu.1_Missense_Mutation_p.R177Q|APPL2_uc009zuq.2_Missense_Mutation_p.R128Q	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	171	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CTGCTTCCGCCGGGCCGCGGC	0.522													T	105600948	T	T	105600948	3	4	140	1	0	0	0	0	1	0	0	0	818	652	23	2	1538	2	APPL2	12	105600948	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	49912116	105600948	28250947	48	9607											
GZMB	3002	broad.mit.edu	37	chr14	25100297	25100297	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttagtagcgtttcatggtttTctttatccagtgtacaaagc	8	7	2	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr14:25100297T>C	uc001wps.2	-	5	790	c.724A>G	c.(724-726)AAA>GAA	p.K242E	GZMB_uc010ama.2_Missense_Mutation_p.K230E|GZMB_uc010amb.2_RNA	NM_004131	NP_004122	P10144	GRAB_HUMAN	granzyme B precursor	242	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.028)		TTCATGGTTTTCTTTATCCAG	0.493													C	25100297	C	C	25100297	3	2	140	1	0	0	0	0	1	0	0	0	6916	1792	62	4	23	4	GZMB	14	25100297	Missense_Mutation	SNP	T	TCGA-14-1823-01A-01W-0643-08		25100297	82249243	49	9608											
ESRRB	2103	broad.mit.edu	37	chr14	76957925	76957925	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgctgaggactacatcatggAtgaggagcactcccgcctcg	12	13	1	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr14:76957925A>C	uc001xsq.1	+	6	990	c.923A>C	c.(922-924)GAT>GCT	p.D308A	ESRRB_uc001xsr.2_Missense_Mutation_p.D308A|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	308						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		TACATCATGGATGAGGAGCAC	0.592													C	76957925	C	C	76957925	3	2	140	1	0	0	0	0	1	0	0	0	5261	333	12	5	941	5	ESRRB	14	76957925	Missense_Mutation	SNP	A	TCGA-14-1823-01A-01W-0643-08	51857628	76957925	30391615	50	9609											
KCNK13	56659	broad.mit.edu	37	chr14	90528848	90528848	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgctgggacttcaccggcgCcttctacttcgtgggcaccg	13	15	2	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr14:90528848C>T	uc001xye.1	+	1	741	c.299C>T	c.(298-300)GCC>GTC	p.A100V		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	100						integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				TTCACCGGCGCCTTCTACTTC	0.692													T	90528848	T	T	90528848	3	4	140	1	0	0	0	0	1	0	0	0	8061	739	26	3	301	3	KCNK13	14	90528848	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	13570923	90528848	16820692	51	9610											
FOXN1	8456	broad.mit.edu	37	chr17	26862064	26862064	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggcaccccccaggactcgcCtctgcctgcccacaccccac	7	23	1	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr17:26862064C>G	uc010crm.2	+	8	1673	c.1475C>G	c.(1474-1476)CCT>CGT	p.P492R	FOXN1_uc002hbj.2_Missense_Mutation_p.P492R	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	492					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					CAGGACTCGCCTCTGCCTGCC	0.687													G	26862064	G	G	26862064	3	3	140	1	0	0	0	0	1	0	0	0	6019	681	24	5	1501	5	FOXN1	17	26862064	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08		26862064	54333146	52	9611											
HOXB13	10481	broad.mit.edu	37	chr17	46805737	46805737	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taaggcacgggagctggggaCgtcccctggggcaccccagg	17	13	0	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr17:46805737C>A	uc002ioa.2	-	1	375	c.219G>T	c.(217-219)ACG>ACT	p.T73T		NM_006361	NP_006352	Q92826	HXB13_HUMAN	homeobox B13	73					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GAGCTGGGGACGTCCCCTGGG	0.652													A	46805737	A	A	46805737	2	1	140	1	0	0	0	0	0	0	0	1	7300	523	19	5		5	HOXB13	17	46805737	Silent	SNP	C	TCGA-14-1823-01A-01W-0643-08	19943673	46805737	34389473	53	9612											
C18orf62	284274	broad.mit.edu	37	chr18	73139434	73139434	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaattccccttgaatatccGtcccattcctgcagagtctt	5	14	1	2	rs142533881		TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr18:73139434G>A	uc002lma.1	-	1	156	c.85C>T	c.(85-87)CGG>TGG	p.R29W	C18orf62_uc010dqw.1_RNA|C18orf62_uc002lmb.1_RNA	NM_001037331	NP_001032408	Q3B7S5	CR062_HUMAN	hypothetical protein LOC284274	29						integral to membrane					0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		OV - Ovarian serous cystadenocarcinoma(15;6.21e-06)		TTGAATATCCGTCCCATTCCT	0.498													A	73139434	A	A	73139434	3	1	140	1	0	0	0	0	1	0	0	0	1906	1144	40	1	232	1	C18orf62	18	73139434	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08		73139434	4937814	54	9613											
FAM187B	148109	broad.mit.edu	37	chr19	35718884	35718884	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtacatggatcctaagggacAgtcgagccacacaaattctg	10	10	1	0			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr19:35718884A>T	uc002nyk.1	-	1	745	c.700T>A	c.(700-702)TGT>AGT	p.C234S		NM_152481	NP_689694	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	234	Extracellular (Potential).					integral to membrane				ovary(2)	2						CCTAAGGGACAGTCGAGCCAC	0.507													T	35718884	T	T	35718884	3	4	140	1	0	0	0	0	1	0	0	0	5513	188	7	5	417	5	FAM187B	19	35718884	Missense_Mutation	SNP	A	TCGA-14-1823-01A-01W-0643-08		35718884	23410099	55	9614											
ZIM3	114026	broad.mit.edu	37	chr19	57647409	57647409	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atgggacttctcttgcgagaCtctctttcacatcctttggc	8	12	3	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr19:57647409C>G	uc002qnz.1	-	5	682	c.296G>C	c.(295-297)AGT>ACT	p.S99T		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCTTGCGAGACTCTCTTTCAC	0.408													G	57647409	G	G	57647409	3	3	140	1	0	0	0	0	1	0	0	0	17682	565	20	5	1126	5	ZIM3	19	57647409	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	21928525	57647409	1481574	56	9615											
HNF4A	3172	broad.mit.edu	37	chr20	43048412	43048412	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagctggcggagatgagccGggtgtccatacgcatccttg	16	10	0	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr20:43048412G>A	uc002xma.2	+	7	877	c.788G>A	c.(787-789)CGG>CAG	p.R263Q	HNF4A_uc002xlt.2_Missense_Mutation_p.R241Q|HNF4A_uc002xlu.2_Missense_Mutation_p.R241Q|HNF4A_uc002xlv.2_Missense_Mutation_p.R241Q|HNF4A_uc002xly.2_Missense_Mutation_p.R263Q|HNF4A_uc002xlz.2_Missense_Mutation_p.R263Q|HNF4A_uc010ggq.2_Missense_Mutation_p.R256Q	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	263					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GAGATGAGCCGGGTGTCCATA	0.572													A	43048412	A	A	43048412	3	1	140	1	0	0	0	0	1	0	0	0	7253	1116	39	2	867	2	HNF4A	20	43048412	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08		43048412	19977108	57	9616											
PABPC1L	80336	broad.mit.edu	37	chr20	43545422	43545422	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtgacgagcatggctcccGgggtttcggctttgtccatt	14	10	0	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr20:43545422G>A	uc010ggv.1	+	3	495	c.413G>A	c.(412-414)CGG>CAG	p.R138Q	PABPC1L_uc010zwq.1_RNA	NM_001124756	NP_001118228	Q4VXU2	PAP1L_HUMAN	poly(A)-binding protein, cytoplasmic 1-like	138	RRM 2.						nucleotide binding|RNA binding			ovary(1)	1						CATGGCTCCCGGGGTTTCGGC	0.557													A	43545422	A	A	43545422	3	1	140	1	0	0	0	0	1	0	0	0	11364	1116	39	2	423	2	PABPC1L	20	43545422	Missense_Mutation	SNP	G	TCGA-14-1823-01A-01W-0643-08	497010	43545422	19480098	58	9617											
RBPJL	11317	broad.mit.edu	37	chr20	43938206	43938206	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acctgcctgccctactcccaGgtcatccccagagcacacca	6	20	1	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chr20:43938206G>T	uc002xns.2	+	3	204	c.132_splice	c.e3-1	p.R44_splice	MATN4_uc002xnn.2_5'Flank|MATN4_uc002xno.2_5'Flank|MATN4_uc002xnp.2_5'Flank|MATN4_uc002xnr.1_5'Flank|RBPJL_uc002xnt.2_Splice_Site_p.R44_splice	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L						signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CCTACTCCCAGGTCATCCCCA	0.607													T	43938206	T	T	43938206	5	4	140	1	0	0	0	0	0	0	1	0	13162	1014	35	5	141	5	RBPJL	20	43938206	Splice_Site	SNP	G	TCGA-14-1823-01A-01W-0643-08	392784	43938206	19087314	59	9618											
SSX1	6756	broad.mit.edu	37	chrX	48118025	48118025	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	taaacaggccacagacttccAggggaatgattttgataatg	10	7	0	3			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chrX:48118025A>T	uc004djb.1	+	4	330	c.239A>T	c.(238-240)CAG>CTG	p.Q80L		NM_005635	NP_005626	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	80	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)	soft_tissue(1169)	1169						ACAGACTTCCAGGGGAATGAT	0.428													T	48118025	T	T	48118025	3	4	140	1	0	0	0	0	1	0	0	0	15202	188	7	5	249	5	SSX1	23	48118025	Missense_Mutation	SNP	A	TCGA-14-1823-01A-01W-0643-08		48118025	107152535	60	9619											
FOXP3	50943	broad.mit.edu	37	chrX	49113238	49113238	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cctctggctcttcgaagaccTtctcacatccgggccacttg	8	16	3	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chrX:49113238T>A	uc004dnf.3	-	6	805	c.617A>T	c.(616-618)AAG>ATG	p.K206M	FOXP3_uc011mnb.1_Missense_Mutation_p.K229M|FOXP3_uc011mnc.1_Missense_Mutation_p.K206M|FOXP3_uc004dne.3_Missense_Mutation_p.K171M|FOXP3_uc010niq.1_Missense_Mutation_p.K171M	NM_014009	NP_054728	Q9BZS1	FOXP3_HUMAN	forkhead box P3 isoform a	206	C2H2-type.				B cell homeostasis|cerebellum development|chromatin remodeling|embryo development|myeloid cell homeostasis|negative regulation of activated T cell proliferation|negative regulation of chronic inflammatory response|negative regulation of CREB transcription factor activity|negative regulation of cytokine secretion|negative regulation of histone acetylation|negative regulation of histone deacetylation|negative regulation of interferon-gamma biosynthetic process|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of interleukin-2 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of interleukin-6 production|negative regulation of isotype switching to IgE isotypes|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell cytokine production|negative regulation of tumor necrosis factor production|pattern specification process|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of histone acetylation|positive regulation of immature T cell proliferation in thymus|positive regulation of peripheral T cell tolerance induction|positive regulation of T cell anergy|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor-beta1 production|post-embryonic development|regulation of isotype switching to IgG isotypes|response to virus|T cell homeostasis|T cell receptor signaling pathway|tolerance induction to self antigen	cytoplasm|cytoplasm|nucleus|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|histone acetyltransferase binding|histone deacetylase binding|NF-kappaB binding|NFAT protein binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription corepressor activity|zinc ion binding				0	Ovarian(276;0.236)					TTCGAAGACCTTCTCACATCC	0.617													A	49113238	A	A	49113238	3	1	140	1	0	0	0	0	1	0	0	0	6028	1609	56	5	706	5	FOXP3	23	49113238	Missense_Mutation	SNP	T	TCGA-14-1823-01A-01W-0643-08	995213	49113238	106157322	61	9620											
HUWE1	10075	broad.mit.edu	37	chrX	53590731	53590731	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aattgtactgttcccagatcCgccatccctctcaagcaact	5	15	1	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chrX:53590731C>T	uc004dsp.2	-	52	7483	c.7081G>A	c.(7081-7083)GGA>AGA	p.G2361R	HUWE1_uc004dsn.2_Missense_Mutation_p.G1185R	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2361	Glu-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TTCCCAGATCCGCCATCCCTC	0.453													T	53590731	T	T	53590731	3	4	140	1	0	0	0	0	1	0	0	0	7461	661	23	2	6175	2	HUWE1	23	53590731	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	4477493	53590731	101679829	62	9621											
AWAT2	158835	broad.mit.edu	37	chrX	69261810	69261810	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcattggtagaggctcccCgactgccaggggagacagtg	17	10	0	2			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chrX:69261810C>T	uc004dxt.1	-	7	856	c.850G>A	c.(850-852)GGG>AGG	p.G284R		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	284						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0						AGAGGCTCCCCGACTGCCAGG	0.502													T	69261810	T	T	69261810	3	4	140	1	0	0	0	0	1	0	0	0	1235	652	23	2	155	2	AWAT2	23	69261810	Missense_Mutation	SNP	C	TCGA-14-1823-01A-01W-0643-08	15671079	69261810	86008750	63	9622											
OTUD6A	139562	broad.mit.edu	37	chrX	69282974	69282974	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accagcgactccttcggctaCgacgacttcatgatctactg	8	14	2	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chrX:69282974C>T	uc004dxu.1	+	1	634	c.600C>T	c.(598-600)TAC>TAT	p.Y200Y		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	200	OTU.									lung(1)|skin(1)	2						CCTTCGGCTACGACGACTTCA	0.622													T	69282974	T	T	69282974	2	4	140	1	0	0	0	0	0	0	0	1	11316	547	19	1		1	OTUD6A	23	69282974	Silent	SNP	C	TCGA-14-1823-01A-01W-0643-08	21164	69282974	85987586	64	9623											
P2RY10	27334	broad.mit.edu	37	chrX	78216461	78216461	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagactggaagcgtaggtaCgatgtgggcatcagtgctgc	16	7	1	1			TCGA-14-1823-01A-01W-0643-08	TCGA-14-1823-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c3ddf6a-e496-4b87-833b-084d814b6876	4ba7b443-5214-4348-bac2-977d5d76b2f8	g.chrX:78216461C>T	uc004ede.2	+	4	813	c.444C>T	c.(442-444)TAC>TAT	p.Y148Y	P2RY10_uc004edf.2_Silent_p.Y148Y	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	148	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						AGCGTAGGTACGATGTGGGCA	0.498													T	78216461	T	T	78216461	2	4	140	1	0	0	0	0	0	0	0	1	11347	547	19	1		1	P2RY10	23	78216461	Silent	SNP	C	TCGA-14-1823-01A-01W-0643-08	8933487	78216461	77054099	65	9624											
PEX14	5195	broad.mit.edu	37	chr1	10683104	10683104	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctccccctcatcctgggcgGccgagaggacagaaagcagc	13	15	1	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr1:10683104G>T	uc001arn.2	+	6	434	c.413G>T	c.(412-414)GGC>GTC	p.G138V	PEX14_uc009vmu.1_Missense_Mutation_p.G95V|PEX14_uc009vmv.2_Missense_Mutation_p.G74V|PEX14_uc010oam.1_Missense_Mutation_p.G74V|PEX14_uc010oan.1_Missense_Mutation_p.G95V|PEX14_uc009vmw.2_Missense_Mutation_p.G74V	NM_004565	NP_004556	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	138					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(1)	1	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		ATCCTGGGCGGCCGAGAGGAC	0.557													T	10683104	T	T	10683104	3	4	141	1	0	0	0	0	1	0	0	0	11742	1203	42	5	435	5	PEX14	1	10683104	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		10683104	238567517	1	9625											
CLCNKB	1188	broad.mit.edu	37	chr1	16378220	16378220	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaggagctgctatcgggcGcctctttggggagactctct	14	12	2	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr1:16378220G>A	uc001axw.3	+	14	1393	c.1313G>A	c.(1312-1314)CGC>CAC	p.R438H	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.R438H|CLCNKB_uc001axy.3_Missense_Mutation_p.R269H	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	438			R -> C (in BS3).		excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		GCTATCGGGCGCCTCTTTGGG	0.622													A	16378220	A	A	16378220	3	1	141	1	0	0	0	0	1	0	0	0	3470	1087	38	1	1511	1	CLCNKB	1	16378220	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	5695116	16378220	232872401	2	9626											
SRRM1	10250	broad.mit.edu	37	chr1	24996658	24996658	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aagaagggtctcatcctcccGatctgtctccgggtctcctg	10	14	4	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr1:24996658G>A	uc001bjm.2	+	15	2476	c.2252G>A	c.(2251-2253)CGA>CAA	p.R751Q	SRRM1_uc010oel.1_Missense_Mutation_p.R763Q|SRRM1_uc009vri.1_Missense_Mutation_p.R680Q	NM_005839	NP_005830	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	751	Pro-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		TCATCCTCCCGATCTGTCTCC	0.532													A	24996658	A	A	24996658	3	1	141	1	0	0	0	0	1	0	0	0	15167	1058	37	2	2310	2	SRRM1	1	24996658	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	8618438	24996658	224253963	3	9627											
TAL1	6886	broad.mit.edu	37	chr1	47685764	47685764	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggatcagcttgcggagctcGgcaaaggccccgttcacatt	13	12	2	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr1:47685764G>A	uc001cqx.2	-	4	1201	c.624C>T	c.(622-624)GCC>GCT	p.A208A	TAL1_uc009vyq.2_5'UTR|TAL1_uc001cqy.2_Silent_p.A208A	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	208	Helix-loop-helix motif.				basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1						TGCGGAGCTCGGCAAAGGCCC	0.572			T	TRD@|SIL	lymphoblastic leukemia/biphasic								A	47685764	A	A	47685764	2	1	141	1	0	0	0	0	0	0	0	1	15538	1103	39	2		2	TAL1	1	47685764	Silent	SNP	G	TCGA-14-1825-01A-01W-0643-08	22689106	47685764	201564857	4	9628											
L1TD1	54596	broad.mit.edu	37	chr1	62675593	62675593	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcaagaggaagagttttccGagctagaggagctggatgaa	14	6	1	4			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr1:62675593G>A	uc001dae.3	+	4	1449	c.1147G>A	c.(1147-1149)GAG>AAG	p.E383K		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	383	Glu-rich.									ovary(1)|skin(1)	2						AGAGTTTTCCGAGCTAGAGGA	0.358													A	62675593	A	A	62675593	3	1	141	1	0	0	0	0	1	0	0	0	8589	1059	37	2	1153	2	L1TD1	1	62675593	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	14989829	62675593	186575028	5	9629											
PPFIA4	8497	broad.mit.edu	37	chr1	203029484	203029484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgcaccggctcaagctccGcctggccattcaggagatgg	12	15	2	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr1:203029484G>A	uc001gyz.2	+	9	1798	c.1205G>A	c.(1204-1206)CGC>CAC	p.R402H	PPFIA4_uc009xaj.2_Missense_Mutation_p.R1033H|PPFIA4_uc010pqf.1_Missense_Mutation_p.R615H|PPFIA4_uc001gza.2_Missense_Mutation_p.R402H|PPFIA4_uc001gzb.1_Missense_Mutation_p.R97H	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	402	SAM 1.				cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						CTCAAGCTCCGCCTGGCCATT	0.612													A	203029484	A	A	203029484	3	1	141	1	0	0	0	0	1	0	0	0	12312	1087	38	1	1239	1	PPFIA4	1	203029484	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	140353891	203029484	46221137	6	9630											
TET3	200424	broad.mit.edu	37	chr2	74274539	74274539	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaggcaccctcttcctccCcggccccggccccatcccct	8	23	1	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr2:74274539C>T	uc002skb.3	+	1	1090	c.1090C>T	c.(1090-1092)CCG>TCG	p.P364S	TET3_uc010fez.1_Missense_Mutation_p.P364S	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	364							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTCTTCCTCCCCGGCCCCGGC	0.652													T	74274539	T	T	74274539	3	4	141	1	0	0	0	0	1	0	0	0	15768	623	22	3	1092	3	TET3	2	74274539	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08		74274539	168924834	7	9631											
FAM123C	205147	broad.mit.edu	37	chr2	131521195	131521195	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggctgcgccgaggccccaCgccccgtgccccacccaccc	10	24	0	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr2:131521195C>T	uc002trw.2	+	2	1740	c.1550C>T	c.(1549-1551)ACG>ATG	p.T517M	FAM123C_uc010fmv.2_Missense_Mutation_p.T517M|FAM123C_uc010fms.1_Missense_Mutation_p.T517M|FAM123C_uc010fmt.1_Missense_Mutation_p.T517M|FAM123C_uc010fmu.1_Missense_Mutation_p.T517M	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	517										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CGAGGCCCCACGCCCCGTGCC	0.687													T	131521195	T	T	131521195	3	4	141	1	0	0	0	0	1	0	0	0	5424	536	19	1	1552	1	FAM123C	2	131521195	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	57246656	131521195	111678178	8	9632											
THSD7B	80731	broad.mit.edu	37	chr2	137988713	137988713	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgtgctgagcgagtggaCggagtggtcatcctgttccc	15	10	1	1	rs61741154		TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr2:137988713C>T	uc002tva.1	+	7	1730	c.1730C>T	c.(1729-1731)ACG>ATG	p.T577M	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.T467M	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AGCGAGTGGACGGAGTGGTCA	0.517													T	137988713	T	T	137988713	3	4	141	1	0	0	0	0	1	0	0	0	15877	536	19	1	1756	1	THSD7B	2	137988713	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	6467518	137988713	105210660	9	9633											
XIRP2	129446	broad.mit.edu	37	chr2	168101235	168101235	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctctttatgaaaaagtttcGttaatgaccagcagtgaaga	8	6	1	4			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr2:168101235G>A	uc002udx.2	+	8	3351	c.3333G>A	c.(3331-3333)TCG>TCA	p.S1111S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.S936S|XIRP2_uc010fpq.2_Silent_p.S889S|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	936					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAAAAGTTTCGTTAATGACCA	0.368													A	168101235	A	A	168101235	2	1	141	1	0	0	0	0	0	0	0	1	17427	1132	40	1		1	XIRP2	2	168101235	Silent	SNP	G	TCGA-14-1825-01A-01W-0643-08	30112522	168101235	75098138	10	9634											
TTN	7273	broad.mit.edu	37	chr2	179647001	179647001	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatggggctttgggttgccGccaacttggcatccaaacac	11	12	0	0	rs141768043		TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr2:179647001G>A	uc010zfg.1	-	20	3542	c.3318C>T	c.(3316-3318)GGC>GGT	p.G1106G	TTN_uc010zfh.1_Silent_p.G1060G|TTN_uc010zfi.1_Silent_p.G1060G|TTN_uc010zfj.1_Silent_p.G1060G|TTN_uc002unb.2_Silent_p.G1106G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1106							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGGTTGCCGCCAACTTGGC	0.488													A	179647001	A	A	179647001	2	1	141	1	0	0	0	0	0	0	0	1	16732	1074	38	1		1	TTN	2	179647001	Silent	SNP	G	TCGA-14-1825-01A-01W-0643-08	11545766	179647001	63552372	11	9635											
METTL6	131965	broad.mit.edu	37	chr3	15468122	15468122	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttcctgaggtgagtttcaCgcctcaaacagcacaggggg	12	10	2	2	rs140376877	by1000genomes	TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr3:15468122C>T	uc003bzs.1	-	2	155	c.-103G>A	c.(-105--101)GCGTG>GCATG		METTL6_uc011avp.1_Translation_Start_Site|METTL6_uc003bzt.1_Translation_Start_Site|EAF1_uc003bzu.2_5'Flank|EAF1_uc011avq.1_5'Flank	NM_152396	NP_689609	Q8TCB7	METL6_HUMAN	methyltransferase like 6								methyltransferase activity				0						GTGAGTTTCACGCCTCAAACA	0.418													T	15468122	T	T	15468122	1	4	141	1	0	0	0	0	0	0	0	0	9504	551	19	1		1	METTL6	3	15468122	Translation_Start_Site	SNP	C	TCGA-14-1825-01A-01W-0643-08		15468122	182554308	12	9636											
TIPARP	25976	broad.mit.edu	37	chr3	156422618	156422618	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctgtggaaagcatgctacaAtgtttggacaaggcagttat	11	6	1	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr3:156422618A>G	uc003fav.2	+	6	1920	c.1672A>G	c.(1672-1674)ATG>GTG	p.M558V	TIPARP_uc003faw.2_Missense_Mutation_p.M558V	NM_015508	NP_056323	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	558	PARP catalytic.						NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|breast(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GCATGCTACAATGTTTGGACA	0.408													G	156422618	G	G	156422618	3	3	141	1	0	0	0	0	1	0	0	0	15921	101	4	4	1690	4	TIPARP	3	156422618	Missense_Mutation	SNP	A	TCGA-14-1825-01A-01W-0643-08	140954496	156422618	41599812	13	9637											
VPS8	23355	broad.mit.edu	37	chr3	184648300	184648300	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaatatcttatccattcccGgacacagtgcagaggagaag	9	10	1	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr3:184648300G>A	uc003fpb.1	+	33	3007	c.2836G>A	c.(2836-2838)GGA>AGA	p.G946R	VPS8_uc010hyd.1_Missense_Mutation_p.G856R|VPS8_uc010hye.1_Missense_Mutation_p.G375R	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	948							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			ATCCATTCCCGGACACAGTGC	0.393													A	184648300	A	A	184648300	3	1	141	1	0	0	0	0	1	0	0	0	17215	1117	39	2	2968	2	VPS8	3	184648300	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	28225682	184648300	13374130	14	9638											
C4orf35	85438	broad.mit.edu	37	chr4	71201281	71201281	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcagtgctggtgttgctgaCgctcctgcctttccacgtaa	11	12	0	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr4:71201281C>T	uc003hff.2	+	1	611	c.525C>T	c.(523-525)GAC>GAT	p.D175D		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	175						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				GTGTTGCTGACGCTCCTGCCT	0.463													T	71201281	T	T	71201281	2	4	141	1	0	0	0	0	0	0	0	1	2265	535	19	1		1	C4orf35	4	71201281	Silent	SNP	C	TCGA-14-1825-01A-01W-0643-08		71201281	119952995	15	9639											
FGG	2266	broad.mit.edu	37	chr4	155528020	155528020	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacttgtcactaggatcatcGccaaaatcaaagccatcaaa	5	11	4	0	rs146218442		TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr4:155528020G>A	uc003ioj.2	-	8	1107	c.966C>T	c.(964-966)GGC>GGT	p.G322G	FGG_uc003iog.2_Silent_p.G322G|FGG_uc003ioh.2_Silent_p.G330G|FGG_uc010ipx.2_Silent_p.G150G|FGG_uc010ipy.2_Silent_p.G33G|FGG_uc003ioi.2_Silent_p.G33G|FGG_uc003iok.2_Silent_p.G330G	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	322	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TAGGATCATCGCCAAAATCAA	0.473													A	155528020	A	A	155528020	2	1	141	1	0	0	0	0	0	0	0	1	5870	1074	38	1		1	FGG	4	155528020	Silent	SNP	G	TCGA-14-1825-01A-01W-0643-08	84326739	155528020	35626256	16	9640											
NKD2	85409	broad.mit.edu	37	chr5	1033572	1033572	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggagagagggcagcaaaccgCgagggcccgcgaggaccggg	20	11	0	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr5:1033572C>G	uc003jbt.1	+	5	293	c.288C>G	c.(286-288)CGC>CGG	p.R96R	NKD2_uc010itf.1_Silent_p.R96R	NM_033120	NP_149111	Q969F2	NKD2_HUMAN	naked cuticle homolog 2	96	Targeting to the basolateral cell membrane.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding				0	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			CAGCAAACCGCGAGGGCCCGC	0.692													G	1033572	G	G	1033572	2	3	141	1	0	0	0	0	0	0	0	1	10442	755	27	5		5	NKD2	5	1033572	Silent	SNP	C	TCGA-14-1825-01A-01W-0643-08		1033572	179881688	17	9641											
PCDHGB2	56103	broad.mit.edu	37	chr5	140741624	140741624	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagggacgcggcccgccagcGcctgctggtcgctgtgcgtg	17	15	0	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr5:140741624G>A	uc003ljs.1	+	1	1922	c.1922G>A	c.(1921-1923)CGC>CAC	p.R641H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.R641H|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	641	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCGCCAGCGCCTGCTGGTC	0.687													A	140741624	A	A	140741624	3	1	141	1	0	0	0	0	1	0	0	0	11563	1087	38	1	1924	1	PCDHGB2	5	140741624	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	139708052	140741624	40173636	18	9642											
KIF4B	285643	broad.mit.edu	37	chr5	154396976	154396976	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtcaaagaagactgctccagCtccctccccttttgacctcc	6	17	1	3			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr5:154396976C>A	uc010jih.1	+	1	3717	c.3557C>A	c.(3556-3558)GCT>GAT	p.A1186D		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1186	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ACTGCTCCAGCTCCCTCCCCT	0.493													A	154396976	A	A	154396976	3	1	141	1	0	0	0	0	1	0	0	0	8304	797	28	5	3559	5	KIF4B	5	154396976	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	13655352	154396976	26518284	19	9643											
DUSP22	56940	broad.mit.edu	37	chr6	335117	335117	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tttttattattctgcagggaGttaaatacctgtgcatccca	7	8	1	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr6:335117G>T	uc003msx.2	+	4	581	c.142G>T	c.(142-144)GTT>TTT	p.V48F	DUSP22_uc011dhn.1_Missense_Mutation_p.V48F|DUSP22_uc003msy.1_Missense_Mutation_p.V5F	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	48					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		TCTGCAGGGAGTTAAATACCT	0.299													T	335117	T	T	335117	3	4	141	1	0	0	0	0	1	0	0	0	4821	1029	36	5	156	5	DUSP22	6	335117	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		335117	170779950	20	9644											
HFE	3077	broad.mit.edu	37	chr6	26091215	26091215	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagccccgaactccatggGtttccagtagaatttcaagc	10	11	1	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr6:26091215G>A	uc003nfx.1	+	2	383	c.223G>A	c.(223-225)GTT>ATT	p.V75I	HFE_uc003nfy.1_Missense_Mutation_p.V52I|HFE_uc010jqe.1_Missense_Mutation_p.V75I|HFE_uc003nfz.1_Intron|HFE_uc003ngd.1_Intron|HFE_uc003nga.1_Missense_Mutation_p.V75I|HFE_uc003ngb.1_Missense_Mutation_p.V75I|HFE_uc003ngc.1_Missense_Mutation_p.V75I|HFE_uc003nge.1_Intron|HFE_uc003ngf.1_Intron	NM_000410	NP_000401	Q30201	HFE_HUMAN	hemochromatosis protein isoform 1 precursor	75	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding				0						AACTCCATGGGTTTCCAGTAG	0.488									Hemochromatosis				A	26091215	A	A	26091215	3	1	141	1	0	0	0	0	1	0	0	0	7081	1261	44	3	229	3	HFE	6	26091215	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	25756098	26091215	145023852	21	9645											
C6orf170	221322	broad.mit.edu	37	chr6	121625568	121625568	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgatattcatttagaagaCgaacctacaaagcagtgcac	7	9	2	3			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr6:121625568C>T	uc003pyo.1	-	8	946	c.878G>A	c.(877-879)CGT>CAT	p.R293H	C6orf170_uc003pyq.1_RNA	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	293					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		ATTTAGAAGACGAACCTACAA	0.358													T	121625568	T	T	121625568	3	4	141	1	0	0	0	0	1	0	0	0	2344	536	19	1	2995	1	C6orf170	6	121625568	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	95534353	121625568	49489499	22	9646											
RBAK	57786	broad.mit.edu	37	chr7	5097035	5097035	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgatgttggagaactataGccatctagtttctgtgggtg	13	5	2	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr7:5097035G>A	uc010kss.1	+	4	449	c.125G>A	c.(124-126)AGC>AAC	p.S42N	LOC389458_uc003snr.2_Missense_Mutation_p.S42N|RBAK_uc003sns.1_Missense_Mutation_p.S42N	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	42	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		GAGAACTATAGCCATCTAGTT	0.433													A	5097035	A	A	5097035	3	1	141	1	0	0	0	0	1	0	0	0	13100	971	34	3	131	3	RBAK	7	5097035	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		5097035	154041628	23	9647											
PDGFRL	5157	broad.mit.edu	37	chr8	17447275	17447275	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttaaggattctcgcctcagGtaagcatttttttttaaaac	6	7	2	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr8:17447275G>A	uc003wxr.2	+	2	414	c.353_splice	c.e2+1	p.S118_splice		NM_006207	NP_006198	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like							extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity				0				Colorectal(111;0.0752)		CTCGCCTCAGGTAAGCATTTT	0.403													A	17447275	A	A	17447275	5	1	141	1	0	0	0	0	0	0	1	0	11663	1275	44	3	360	3	PDGFRL	8	17447275	Splice_Site	SNP	G	TCGA-14-1825-01A-01W-0643-08		17447275	128916747	24	9648											
RANBP6	26953	broad.mit.edu	37	chr9	6014248	6014248	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	attttccatggtacgtaacaGagctgcaatcactgtttcat	7	9	2	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr9:6014248G>T	uc003zjr.2	-	1	1371	c.1360C>A	c.(1360-1362)CTG>ATG	p.L454M	RANBP6_uc011lmf.1_Missense_Mutation_p.L102M|RANBP6_uc003zjs.2_Missense_Mutation_p.L42M	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	454	HEAT 4.				protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		GTACGTAACAGAGCTGCAATC	0.413													T	6014248	T	T	6014248	3	4	141	1	0	0	0	0	1	0	0	0	13031	933	33	5	1961	5	RANBP6	9	6014248	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		6014248	135199183	25	9649											
PLIN2	123	broad.mit.edu	37	chr9	19120899	19120899	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagttcttcctcagtgagagGgaggtactgttctaccaaca	10	9	3	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr9:19120899G>A	uc003zno.2	-	5	753	c.574C>T	c.(574-576)CCT>TCT	p.P192S	PLIN2_uc011lna.1_Missense_Mutation_p.P164S|PLIN2_uc011lnb.1_Intron	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	192					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						TCAGTGAGAGGGAGGTACTGT	0.403													A	19120899	A	A	19120899	3	1	141	1	0	0	0	0	1	0	0	0	12090	1232	43	3	755	3	PLIN2	9	19120899	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	13106651	19120899	122092532	26	9650											
TMOD1	7111	broad.mit.edu	37	chr9	100353675	100353675	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actttacccagcaaggacccCggcttcgggcatccaacgca	9	16	0	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr9:100353675C>T	uc004axk.1	+	9	1186	c.973C>T	c.(973-975)CGG>TGG	p.R325W	TMOD1_uc004axl.1_Missense_Mutation_p.R325W	NM_003275	NP_003266	P28289	TMOD1_HUMAN	tropomodulin 1	325					muscle filament sliding	cytosol	actin binding				0		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		GCAAGGACCCCGGCTTCGGGC	0.512													T	100353675	T	T	100353675	3	4	141	1	0	0	0	0	1	0	0	0	16230	643	23	2	1003	2	TMOD1	9	100353675	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	81232776	100353675	40859756	27	9651											
SLC44A1	23446	broad.mit.edu	37	chr9	108110683	108110683	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaagccttctgaatacactAcatctccaaaatcttctgtt	3	11	4	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr9:108110683A>G	uc004bcn.2	+	5	672	c.451A>G	c.(451-453)ACA>GCA	p.T151A	SLC44A1_uc010mtk.1_Missense_Mutation_p.T151A	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	151	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	TGAATACACTACATCTCCAAA	0.373													G	108110683	G	G	108110683	3	3	141	1	0	0	0	0	1	0	0	0	14635	391	14	4	469	4	SLC44A1	9	108110683	Missense_Mutation	SNP	A	TCGA-14-1825-01A-01W-0643-08	7757008	108110683	33102748	28	9652											
MED22	6837	broad.mit.edu	37	chr9	136211100	136211100	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgctggttgcgctggtcaAtggcctcgttcacggagggg	17	10	2	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr9:136211100A>G	uc004cdc.2	-	4	527	c.293T>C	c.(292-294)ATT>ACT	p.I98T	MED22_uc004cdd.2_Missense_Mutation_p.I98T	NM_133640	NP_598395	Q15528	MED22_HUMAN	mediator complex subunit 22 isoform b	98	Potential.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|mediator complex|soluble fraction	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.14e-06)|Epithelial(140;8.2e-06)|all cancers(34;6.94e-05)		GCGCTGGTCAATGGCCTCGTT	0.602													G	136211100	G	G	136211100	3	3	141	1	0	0	0	0	1	0	0	0	9440	101	4	4	327	4	MED22	9	136211100	Missense_Mutation	SNP	A	TCGA-14-1825-01A-01W-0643-08	28100417	136211100	5002331	29	9653											
THNSL1	79896	broad.mit.edu	37	chr10	25313035	25313035	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acgtagaaagagcacagataCtgttggaaagatgtatccat	10	6	0	4			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr10:25313035C>A	uc001isi.3	+	3	1212	c.883C>A	c.(883-885)CTG>ATG	p.L295M	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	295					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	AGCACAGATACTGTTGGAAAG	0.458													A	25313035	A	A	25313035	3	1	141	1	0	0	0	0	1	0	0	0	15859	564	20	5	885	5	THNSL1	10	25313035	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08		25313035	110221712	30	9654											
OR52R1	119695	broad.mit.edu	37	chr11	4825094	4825094	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctggggaatggcttggtgttGgcagaagggcatcctagaca	16	7	0	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr11:4825094G>T	uc010qym.1	-	1	754	c.754C>A	c.(754-756)CAA>AAA	p.Q252K		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTTGGTGTTGGCAGAAGGGC	0.552													T	4825094	T	T	4825094	3	4	141	1	0	0	0	0	1	0	0	0	11131	1357	47	5	433	5	OR52R1	11	4825094	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		4825094	130181422	31	9655											
APBB1	322	broad.mit.edu	37	chr11	6424912	6424912	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggctgctcccctgtgaggGggaggcccggccggggggtt	22	11	0	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr11:6424912G>A	uc001mdb.1	-	3	962	c.862C>T	c.(862-864)CCC>TCC	p.P288S	APBB1_uc001mcz.1_5'Flank|APBB1_uc001mdd.3_Missense_Mutation_p.P68S|APBB1_uc001mda.2_Intron|APBB1_uc001mdc.1_Missense_Mutation_p.P288S|APBB1_uc010rab.1_5'Flank|APBB1_uc010rac.1_5'Flank|APBB1_uc010rad.1_5'Flank|APBB1_uc010rae.1_Missense_Mutation_p.P53S|APBB1_uc010raf.1_Missense_Mutation_p.P29S|APBB1_uc009yfa.2_Missense_Mutation_p.P29S|APBB1_uc009yey.2_Missense_Mutation_p.P29S|APBB1_uc010rag.1_Missense_Mutation_p.P29S|APBB1_uc009yfb.2_Missense_Mutation_p.P29S|APBB1_uc001mde.2_Missense_Mutation_p.P29S|APBB1_uc010rah.1_Missense_Mutation_p.P29S	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	288					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CCCTGTGAGGGGGAGGCCCGG	0.652													A	6424912	A	A	6424912	3	1	141	1	0	0	0	0	1	0	0	0	759	1232	43	3	1318	3	APBB1	11	6424912	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	1599818	6424912	128581604	32	9656											
OR5M1	390168	broad.mit.edu	37	chr11	56380529	56380529	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacccactaagaaacccataCatgtaagggatagtgaccag	8	10	0	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr11:56380529C>T	uc001nja.1	-	1	450	c.450G>A	c.(448-450)ATG>ATA	p.M150I		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GAAACCCATACATGTAAGGGA	0.458													T	56380529	T	T	56380529	3	4	141	1	0	0	0	0	1	0	0	0	11172	478	17	3	501	3	OR5M1	11	56380529	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	49955617	56380529	78625987	33	9657											
NUMA1	4926	broad.mit.edu	37	chr11	71717105	71717105	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggggccccactggacacccCggcctgggaacgacgagcag	15	15	0	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr11:71717105C>T	uc001orl.1	-	22	5840	c.5668G>A	c.(5668-5670)GGG>AGG	p.G1890R	NUMA1_uc001orj.2_Missense_Mutation_p.G72R|NUMA1_uc009ysw.1_Missense_Mutation_p.G1457R|NUMA1_uc001ork.1_Missense_Mutation_p.G754R|NUMA1_uc001orm.1_Missense_Mutation_p.G1876R	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1890					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CTGGACACCCCGGCCTGGGAA	0.592			T	RARA	APL								T	71717105	T	T	71717105	3	4	141	1	0	0	0	0	1	0	0	0	10750	652	23	2	703	2	NUMA1	11	71717105	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	15336576	71717105	63289411	34	9658											
ADAMTS8	11095	broad.mit.edu	37	chr11	130281492	130281492	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcccagcctccatctgccaCgggctgcaacatacaatggc	9	16	1	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr11:130281492C>T	uc001qgg.3	-	6	1928	c.1570G>A	c.(1570-1572)GTG>ATG	p.V524M	ADAMTS8_uc001qgf.2_Missense_Mutation_p.V5M	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	524	Disintegrin.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CCATCTGCCACGGGCTGCAAC	0.577													T	130281492	T	T	130281492	3	4	141	1	0	0	0	0	1	0	0	0	272	536	19	1	1115	1	ADAMTS8	11	130281492	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	58564387	130281492	4725024	35	9659											
MLL2	8085	broad.mit.edu	37	chr12	49420539	49420539	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agtgccccgccctgggtctcAtacacctccgtggaccaaag	10	16	1	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr12:49420539A>T	uc001rta.3	-	48	15210	c.15210T>A	c.(15208-15210)TAT>TAA	p.Y5070*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5070					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCTGGGTCTCATACACCTCCG	0.632			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			T	49420539	T	T	49420539	4	4	141	1	0	0	0	0	0	1	0	0	9621	224	8	5	1431	5	MLL2	12	49420539	Nonsense_Mutation	SNP	A	TCGA-14-1825-01A-01W-0643-08		49420539	84431356	36	9660											
HOXC13	3229	broad.mit.edu	37	chr12	54332758	54332758	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtacgtctatgaggacagcgCggcggagagcggcatcggcg	18	10	1	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr12:54332758C>T	uc001sei.2	+	1	183	c.68C>T	c.(67-69)GCG>GTG	p.A23V	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	23						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GAGGACAGCgcggcggagagc	0.468			T	NUP98	AML								T	54332758	T	T	54332758	3	4	141	1	0	0	0	0	1	0	0	0	7312	768	27	1	70	1	HOXC13	12	54332758	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	4912219	54332758	79519137	37	9661											
MMP19	4327	broad.mit.edu	37	chr12	56231702	56231702	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tccggggagcccctcccaaaGggcagacactcggaacaagg	13	14	0	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr12:56231702G>C	uc001sib.2	-	7	1106	c.985C>G	c.(985-987)CTT>GTT	p.L329V	MMP19_uc001sia.2_Missense_Mutation_p.L43V|MMP19_uc001sid.2_RNA|MMP19_uc010spw.1_Missense_Mutation_p.P282R	NM_002429	NP_002420	Q99542	MMP19_HUMAN	matrix metalloproteinase 19 isoform rasi-1	329	Hemopexin-like 1.				angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)	1						CCCTCCCAAAGGGCAGACACT	0.542													C	56231702	C	C	56231702	3	2	141	1	0	0	0	0	1	0	0	0	9657	1000	35	5	553	5	MMP19	12	56231702	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	1898944	56231702	77620193	38	9662											
PTPRB	5787	broad.mit.edu	37	chr12	70983775	70983775	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tggcaacgctcagaattcttCaaatttccactctcaacaat	4	12	4	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr12:70983775C>T	uc001swb.3	-	6	1395	c.1365G>A	c.(1363-1365)TTG>TTA	p.L455L	PTPRB_uc010sto.1_Silent_p.L455L|PTPRB_uc010stp.1_Intron|PTPRB_uc001swc.3_Silent_p.L673L|PTPRB_uc001swa.3_Silent_p.L673L|PTPRB_uc001swd.3_Silent_p.L672L|PTPRB_uc009zrr.1_Silent_p.L552L	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	455	Fibronectin type-III 5.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CAGAATTCTTCAAATTTCCAC	0.458											OREG0021990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	70983775	T	T	70983775	2	4	141	1	0	0	0	0	0	0	0	1	12796	825	29	3		3	PTPRB	12	70983775	Silent	SNP	C	TCGA-14-1825-01A-01W-0643-08	14752073	70983775	62868120	39	9663											
MYF6	4618	broad.mit.edu	37	chr12	81101567	81101567	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggaaaatgttactctgcaGccattagaagtggcagaagg	14	6	1	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr12:81101567G>A	uc001szf.1	+	1	122	c.69G>A	c.(67-69)CAG>CAA	p.Q23Q		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	23					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						TTACTCTGCAGCCATTAGAAG	0.517													A	81101567	A	A	81101567	2	1	141	1	0	0	0	0	0	0	0	1	10028	962	34	3		3	MYF6	12	81101567	Silent	SNP	G	TCGA-14-1825-01A-01W-0643-08	10117792	81101567	52750328	40	9664											
AACS	65985	broad.mit.edu	37	chr12	125591804	125591804	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgcacccaagtgcatggtgcAttccgctggggtaggtctct	13	12	1	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr12:125591804A>C	uc001uhc.2	+	8	1111	c.905A>C	c.(904-906)CAT>CCT	p.H302P	AACS_uc009zyg.2_RNA|AACS_uc001uhd.2_Missense_Mutation_p.H302P|AACS_uc009zyh.2_RNA|AACS_uc009zyi.2_5'UTR	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	302					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		TGCATGGTGCATTCCGCTGGG	0.607													C	125591804	C	C	125591804	3	2	141	1	0	0	0	0	1	0	0	0	9	217	8	5	935	5	AACS	12	125591804	Missense_Mutation	SNP	A	TCGA-14-1825-01A-01W-0643-08	44490237	125591804	8260091	41	9665											
CYSLTR2	57105	broad.mit.edu	37	chr13	49281611	49281611	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	catttttcacactcagcatcTgttatctgctgatcattcgg	6	11	5	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr13:49281611T>A	uc010acx.1	+	6	1341	c.658T>A	c.(658-660)TGT>AGT	p.C220S	CYSLTR2_uc010acy.1_Missense_Mutation_p.C220S|CYSLTR2_uc010acz.1_Missense_Mutation_p.C220S|CYSLTR2_uc010ada.1_Missense_Mutation_p.C220S|CYSLTR2_uc010adb.1_Missense_Mutation_p.C220S|CYSLTR2_uc010adc.1_Missense_Mutation_p.C220S|CYSLTR2_uc010add.1_Missense_Mutation_p.C220S|CYSLTR2_uc010acw.1_Missense_Mutation_p.C220S|CYSLTR2_uc001vck.2_Missense_Mutation_p.C220S	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	220	Helical; Name=5; (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	ACTCAGCATCTGTTATCTGCT	0.478													A	49281611	A	A	49281611	3	1	141	1	0	0	0	0	1	0	0	0	4202	1580	55	5	660	5	CYSLTR2	13	49281611	Missense_Mutation	SNP	T	TCGA-14-1825-01A-01W-0643-08		49281611	65888267	42	9666											
C13orf16	121793	broad.mit.edu	37	chr13	111995233	111995233	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agcctgcgagtcctgggcctCcaagtgctgggccctcgatg	14	14	0	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr13:111995233C>A	uc001vsa.2	+	5	499	c.370C>A	c.(370-372)CCA>ACA	p.P124T		NM_152324	NP_689537	Q8N6K0	CM016_HUMAN	hypothetical protein LOC121793	124	Cytoplasmic (Potential).					integral to membrane					0	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		all cancers(43;0.113)|GBM - Glioblastoma multiforme(44;0.174)|BRCA - Breast invasive adenocarcinoma(86;0.188)			TCCTGGGCCTCCAAGTGCTGG	0.577													A	111995233	A	A	111995233	3	1	141	1	0	0	0	0	1	0	0	0	1719	855	30	5	384	5	C13orf16	13	111995233	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	62713622	111995233	3174645	43	9667											
ADPRHL1	113622	broad.mit.edu	37	chr13	114079397	114079397	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttctgcatcataattgtcGgggaagatggctttattttc	9	7	3	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr13:114079397G>A	uc001vtq.1	-	5	831	c.744C>T	c.(742-744)CCC>CCT	p.P248P	ADPRHL1_uc001vtp.1_Silent_p.P166P	NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	248					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CATAATTGTCGGGGAAGATGG	0.299													A	114079397	A	A	114079397	2	1	141	1	0	0	0	0	0	0	0	1	332	1103	39	2		2	ADPRHL1	13	114079397	Silent	SNP	G	TCGA-14-1825-01A-01W-0643-08	2084164	114079397	1090481	44	9668											
AARS	16	broad.mit.edu	37	chr16	70310471	70310471	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gccaaagtaagtaacataaaGtctttcaatgggaatgccaa	8	7	2	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr16:70310471G>T	uc002eyn.1	-	4	507	c.397C>A	c.(397-399)CTT>ATT	p.L133I		NM_001605	NP_001596	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	133					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			pancreas(1)	1		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	GTAACATAAAGTCTTTCAATG	0.428													T	70310471	T	T	70310471	3	4	141	1	0	0	0	0	1	0	0	0	19	1029	36	5	2581	5	AARS	16	70310471	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		70310471	20044282	45	9669											
MLYCD	23417	broad.mit.edu	37	chr16	83933176	83933176	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gctatcgcggcctcttccacCacatcagcaagctggacggc	10	16	2	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr16:83933176C>G	uc002fgz.2	+	1	447	c.427C>G	c.(427-429)CAC>GAC	p.H143D		NM_012213	NP_036345	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase precursor	143					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity				0						CCTCTTCCACCACATCAGCAA	0.731													G	83933176	G	G	83933176	3	3	141	1	0	0	0	0	1	0	0	0	9638	594	21	5	429	5	MLYCD	16	83933176	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	13622705	83933176	6421577	46	9670											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attctcttcctctgtgcgccGgtctctcccaggacaggcac	9	16	3	0	rs28934574		TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577094	A	A	7577094	3	1	141	1	0	0	0	0	1	0	0	0	16378	1115	39	2	442	2	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		7577094	73618116	47	9671											
TP53	7157	broad.mit.edu	37	chr17	7578263	7578263	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgcaaatttccttccactcGgataagatgctgaggagggg	12	9	0	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr17:7578263G>A	uc002gim.2	-	6	780	c.586C>T	c.(586-588)CGA>TGA	p.R196*	TP53_uc002gig.1_Nonsense_Mutation_p.R196*|TP53_uc002gih.2_Nonsense_Mutation_p.R196*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R64*|TP53_uc010cng.1_Nonsense_Mutation_p.R64*|TP53_uc002gii.1_Nonsense_Mutation_p.R64*|TP53_uc010cnh.1_Nonsense_Mutation_p.R196*|TP53_uc010cni.1_Nonsense_Mutation_p.R196*|TP53_uc002gij.2_Nonsense_Mutation_p.R196*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R103*|TP53_uc002gio.2_Nonsense_Mutation_p.R64*|TP53_uc010vug.1_Nonsense_Mutation_p.R157*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	196	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(125)|p.R196P(12)|p.0?(7)|p.R196R(5)|p.R196fs*51(4)|p.A189_V197delAPPQHLIRV(4)|p.R196Q(3)|p.K164_P219del(1)|p.R196L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.R64*(1)|p.I195fs*12(1)|p.R103*(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578263	A	A	7578263	4	1	141	1	0	0	0	0	0	1	0	0	16378	1124	39	2	708	2	TP53	17	7578263	Nonsense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	1169	7578263	73616947	48	9672											
PPM1D	8493	broad.mit.edu	37	chr17	58711271	58711271	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacgacctcgactcactcaCaatggacctgttagaaggag	9	11	2	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr17:58711271C>T	uc002iyt.1	+	3	981	c.759C>T	c.(757-759)CAC>CAT	p.H253H	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	253	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			GACTCACTCACAATGGACCTG	0.363													T	58711271	T	T	58711271	2	4	141	1	0	0	0	0	0	0	0	1	12337	477	17	3		3	PPM1D	17	58711271	Silent	SNP	C	TCGA-14-1825-01A-01W-0643-08	51133008	58711271	22483939	49	9673											
EMILIN2	84034	broad.mit.edu	37	chr18	2847912	2847912	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgcctggaaccagatgccCtgtccgtcggcgctggtgta	14	12	0	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr18:2847912C>T	uc002kln.2	+	2	399	c.240C>T	c.(238-240)CCC>CCT	p.P80P		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	80	EMI.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		ACCAGATGCCCTGTCCGTCGG	0.483													T	2847912	T	T	2847912	2	4	141	1	0	0	0	0	0	0	0	1	5094	668	24	3		3	EMILIN2	18	2847912	Silent	SNP	C	TCGA-14-1825-01A-01W-0643-08		2847912	75229336	50	9674											
TCEB3C	162699	broad.mit.edu	37	chr18	44554653	44554653	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcttggcagcctgttttcGggttttgtccgcgggcgccg	14	11	1	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr18:44554653G>A	uc010xdb.1	-	1	1797	c.1561C>T	c.(1561-1563)CGA>TGA	p.R521*	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						GCCTGTTTTCGGGTTTTGTcc	0.353													A	44554653	A	A	44554653	4	1	141	1	0	0	0	0	0	1	0	0	15680	1124	39	2	1726	2	TCEB3C	18	44554653	Nonsense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08	41706741	44554653	33522595	51	9675											
C20orf70	140683	broad.mit.edu	37	chr20	31760743	31760743	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gattgtttttggcaggcatcCttgagaaactgaaggtcgac	12	7	0	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr20:31760743C>A	uc002wyo.1	+	3	234	c.163C>A	c.(163-165)CTT>ATT	p.L55I		NM_080574	NP_542141	Q96DR5	SPLC2_HUMAN	chromosome 20 open reading frame 70 precursor	55						extracellular region	lipid binding			ovary(1)|central_nervous_system(1)	2						GGCAGGCATCCTTGAGAAACT	0.338													A	31760743	A	A	31760743	3	1	141	1	0	0	0	0	1	0	0	0	2116	681	24	5	169	5	C20orf70	20	31760743	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08		31760743	31264777	52	9676											
TRPC4AP	26133	broad.mit.edu	37	chr20	33591328	33591328	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttcttgctgtgctccatcCgctgcagcagccgcaggtac	10	15	1	0	rs146813768		TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr20:33591328C>T	uc002xbk.2	-	18	2175	c.2141G>A	c.(2140-2142)CGG>CAG	p.R714Q	TRPC4AP_uc002xbj.2_RNA|TRPC4AP_uc010zuq.1_Missense_Mutation_p.R305Q|TRPC4AP_uc002xbl.2_Missense_Mutation_p.R706Q|TRPC4AP_uc010zur.1_Missense_Mutation_p.R675Q	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	714					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GTGCTCCATCCGCTGCAGCAG	0.612													T	33591328	T	T	33591328	3	4	141	1	0	0	0	0	1	0	0	0	16578	652	23	2	260	2	TRPC4AP	20	33591328	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	1830585	33591328	29434192	53	9677											
TSHZ2	128553	broad.mit.edu	37	chr20	51870234	51870234	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catttgtccaatcaggatgcCgagaacgagtctctgctgag	11	10	2	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr20:51870234C>T	uc002xwo.2	+	2	1193	c.237C>T	c.(235-237)GCC>GCT	p.A79A		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	79					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			ATCAGGATGCCGAGAACGAGT	0.537													T	51870234	T	T	51870234	2	4	141	1	0	0	0	0	0	0	0	1	16621	639	23	2		2	TSHZ2	20	51870234	Silent	SNP	C	TCGA-14-1825-01A-01W-0643-08	18278906	51870234	11155286	54	9678											
MC3R	4159	broad.mit.edu	37	chr20	54824418	54824418	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccatctgggtctgctgcggCgtctgtggcgtggtgttcat	16	10	4	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr20:54824418C>T	uc002xxb.2	+	1	631	c.519C>T	c.(517-519)GGC>GGT	p.G173G		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	210	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			TCTGCTGCGGCGTCTGTGGCG	0.562													T	54824418	T	T	54824418	2	4	141	1	0	0	0	0	0	0	0	1	9365	755	27	1		1	MC3R	20	54824418	Silent	SNP	C	TCGA-14-1825-01A-01W-0643-08	2954184	54824418	8201102	55	9679											
BAGE2	85319	broad.mit.edu	37	chr21	11058294	11058294	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcacagcatttgatagtGgctccaaagtgcttacaaaa	7	9	2	1			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr21:11058294G>A	uc002yit.1	-	3	354	c.146C>T	c.(145-147)CCA>CTA	p.P49L	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTTGATAGTGGCTCCAAAGT	0.403													A	11058294	A	A	11058294	3	1	141	1	0	0	0	0	1	0	0	0	1292	1348	47	3	191	3	BAGE2	21	11058294	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		11058294	37071601	56	9680											
ACR	49	broad.mit.edu	37	chr22	51183292	51183292	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccctccacctcccaccactcGaccgcccccgattcgacccc	4	26	0	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chr22:51183292G>A	uc003bnh.3	+	5	935	c.923G>A	c.(922-924)CGA>CAA	p.R308Q		NM_001097	NP_001088	P10323	ACRO_HUMAN	acrosin precursor	308					acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		CCCACCACTCGACCGCCCCCG	0.602													A	51183292	A	A	51183292	3	1	141	1	0	0	0	0	1	0	0	0	169	1058	37	2	941	2	ACR	22	51183292	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		51183292	121274	57	9681											
CFP	5199	broad.mit.edu	37	chrX	47486279	47486279	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgcacgtccgttgttccatgGtctggcccaggccacaggtc	12	14	1	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chrX:47486279G>T	uc004dig.3	-	6	959	c.833C>A	c.(832-834)ACC>AAC	p.T278N	CFP_uc004dih.2_Missense_Mutation_p.T278N|CFP_uc004dii.1_Missense_Mutation_p.T214N|CFP_uc010nhu.2_Missense_Mutation_p.T278N	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	278	TSP type-1 4.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3						TTGTTCCATGGTCTGGCCCAG	0.662													T	47486279	T	T	47486279	3	4	141	1	0	0	0	0	1	0	0	0	3293	1261	44	5	592	5	CFP	23	47486279	Missense_Mutation	SNP	G	TCGA-14-1825-01A-01W-0643-08		47486279	107784281	58	9682											
SLC35A2	7355	broad.mit.edu	37	chrX	48762551	48762552	+	Frame_Shift_Del	DEL	GA	-	-													agacacctgcgaagccggagGagagacaggaggccacgacg							TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chrX:48762551_48762552delGA	uc004dlo.1	-	4	638_639	c.634_635delTC	c.(634-636)TCCfs	p.S212fs	SLC35A2_uc011mml.1_Frame_Shift_Del_p.S225fs|SLC35A2_uc004dlp.1_Frame_Shift_Del_p.S212fs|SLC35A2_uc011mmm.1_Frame_Shift_Del_p.S240fs|SLC35A2_uc011mmn.1_Frame_Shift_Del_p.S151fs|SLC35A2_uc004dlr.1_Intron|SLC35A2_uc004dlq.2_Intron	NM_005660	NP_005651	P78381	S35A2_HUMAN	solute carrier family 35, member A2 isoform a	212	Helical; (Potential).				galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)	1						GAAGCCGGAGGAGAGACAGGAG	0.649													-	48762552	-	-	48762551	7	5	141	1	0	1	0	1	0	0	0	0	14571	1174	41	0	719	0	SLC35A2	23	48762551	Frame_Shift_Del	DEL	GA	TCGA-14-1825-01A-01W-0643-08	1276272	48762551	106508009	59	9683											
ITIH5L	347365	broad.mit.edu	37	chrX	54777770	54777770	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgagtctggtccttgtggccCggccttggtggtgcgccaag	16	12	1	0			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chrX:54777770C>T	uc004dtj.2	-	12	3426	c.3396G>A	c.(3394-3396)CCG>CCA	p.P1132P		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	1132					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CCTTGTGGCCCGGCCTTGGTG	0.572													T	54777770	T	T	54777770	2	4	141	1	0	0	0	0	0	0	0	1	7908	639	23	2		2	ITIH5L	23	54777770	Silent	SNP	C	TCGA-14-1825-01A-01W-0643-08	6015219	54777770	100492790	60	9684											
DCAF12L1	139170	broad.mit.edu	37	chrX	125685588	125685588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatgttctgctggtcctggCgcagatccaggaaagagacg	15	9	1	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chrX:125685588C>T	uc004eul.2	-	1	1255	c.1004G>A	c.(1003-1005)CGC>CAC	p.R335H		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	335										skin(3)|ovary(1)	4						CTGGTCCTGGCGCAGATCCAG	0.597													T	125685588	T	T	125685588	3	4	141	1	0	0	0	0	1	0	0	0	4264	768	27	1	391	1	DCAF12L1	23	125685588	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	70907818	125685588	29584972	61	9685											
MAGEA10	4109	broad.mit.edu	37	chrX	151303380	151303380	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcctcaggggtgcagtagCcctctatgaagactatgctt	10	12	2	2			TCGA-14-1825-01A-01W-0643-08	TCGA-14-1825-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	f0d7cb8b-995c-419b-a366-aadb156879bc	3c9a8b63-5c94-4a4a-a37b-4cda6a3c2e54	g.chrX:151303380C>T	uc004ffk.2	-	5	1121	c.713G>A	c.(712-714)GGC>GAC	p.G238D	MAGEA10_uc004ffl.2_Missense_Mutation_p.G238D	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	238	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GGTGCAGTAGCCCTCTATGAA	0.527													T	151303380	T	T	151303380	3	4	141	1	0	0	0	0	1	0	0	0	9164	739	26	3	400	3	MAGEA10	23	151303380	Missense_Mutation	SNP	C	TCGA-14-1825-01A-01W-0643-08	25617792	151303380	3967180	62	9686											
EXOSC10	5394	broad.mit.edu	37	chr1	11151619	11151619	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gggaggacaggctgttgattCttgtttacacctgaggcttc	13	8	1	2	rs146190133		TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:11151619C>G	uc001asa.2	-	4	458	c.408G>C	c.(406-408)AAG>AAC	p.K136N	EXOSC10_uc001asb.2_Missense_Mutation_p.K136N|EXOSC10_uc009vmy.1_Missense_Mutation_p.K136N	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	136					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		GCTGTTGATTCTTGTTTACAC	0.458													G	11151619	G	G	11151619	3	3	142	1	0	0	0	0	1	0	0	0	5314	912	32	5	2337	5	EXOSC10	1	11151619	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08		11151619	238099002	1	9687											
UBIAD1	29914	broad.mit.edu	37	chr1	11334002	11334002	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gtccggttcggagtcttcctCtacacgttgggctgcgtctg	13	12	3	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:11334002C>G	uc001asg.2	+	1	748	c.414C>G	c.(412-414)CTC>CTG	p.L138L		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	138	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		GAGTCTTCCTCTACACGTTGG	0.537													G	11334002	G	G	11334002	2	3	142	1	0	0	0	0	0	0	0	1	16882	900	32	5		5	UBIAD1	1	11334002	Silent	SNP	C	TCGA-14-1829-01A-01W-0643-08	182383	11334002	237916619	2	9688											
TRIM62	55223	broad.mit.edu	37	chr1	33646782	33646782	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cgcgcggcgcggcgcgcgttGaggatggcgtccagcgggaa	20	12	0	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:33646782G>C	uc001bxb.2	-	1	890	c.252C>G	c.(250-252)CTC>CTG	p.L84L		NM_018207	NP_060677	Q9BVG3	TRI62_HUMAN	tripartite motif-containing 62	84						intracellular	zinc ion binding				0		Myeloproliferative disorder(586;0.0393)				GGCGCGCGTTGAGGATGGCGT	0.701													C	33646782	C	C	33646782	2	2	142	1	0	0	0	0	0	0	0	1	16534	1277	45	5		5	TRIM62	1	33646782	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08	22312780	33646782	215603839	3	9689											
TCHH	7062	broad.mit.edu	37	chr1	152080828	152080828	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagcagctgttcgtcttcgCggaattttctgtcgcgctcc	12	12	2	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:152080828C>T	uc001ezp.2	-	2	4865	c.4865G>A	c.(4864-4866)CGC>CAC	p.R1622H	TCHH_uc009wne.1_Missense_Mutation_p.R1622H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1622	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCGTCTTCGCGGAATTTTCT	0.602													T	152080828	T	T	152080828	3	4	142	1	0	0	0	0	1	0	0	0	15697	768	27	1	970	1	TCHH	1	152080828	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	118434046	152080828	97169793	4	9690											
OR10J3	441911	broad.mit.edu	37	chr1	159283794	159283794	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggtggagatgatgaggacaTaggagataaagaccaggccc	15	6	0	5			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:159283794T>A	uc010piu.1	-	1	656	c.656A>T	c.(655-657)TAT>TTT	p.Y219F		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	219	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					GATGAGGACATAGGAGATAAA	0.502													A	159283794	A	A	159283794	3	1	142	1	0	0	0	0	1	0	0	0	10911	1406	49	5	335	5	OR10J3	1	159283794	Missense_Mutation	SNP	T	TCGA-14-1829-01A-01W-0643-08	7202966	159283794	89966827	5	9691											
SLAMF6	114836	broad.mit.edu	37	chr1	160456502	160456502	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcctttcagcaacttacaCgacattgtcaagggcagttg	10	10	2	0	rs151001421		TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:160456502C>T	uc001fwe.1	-	8	1054	c.994G>A	c.(994-996)GTG>ATG	p.V332M	SLAMF6_uc001fwd.1_Missense_Mutation_p.V331M|SLAMF6_uc010pjh.1_Missense_Mutation_p.V282M|SLAMF6_uc010pji.1_Missense_Mutation_p.V221M	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	332						integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			GCAACTTACACGACATTGTCA	0.483													T	160456502	T	T	160456502	3	4	142	1	0	0	0	0	1	0	0	0	14368	536	19	1	8	1	SLAMF6	1	160456502	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	1172708	160456502	88794119	6	9692											
KLHDC8A	55220	broad.mit.edu	37	chr1	205312607	205312607	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcagtccatggggacgccGttgtcgtcacatcccccgat	11	14	1	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:205312607G>A	uc001hcf.1	-	2	694	c.126C>T	c.(124-126)AAC>AAT	p.N42N	KLHDC8A_uc010prg.1_Intron|KLHDC8A_uc001hcg.1_Silent_p.N42N	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	42	Kelch 2.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TGGGGACGCCGTTGTCGTCAC	0.716													A	205312607	A	A	205312607	2	1	142	1	0	0	0	0	0	0	0	1	8362	1136	40	1		1	KLHDC8A	1	205312607	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08	44856105	205312607	43938014	7	9693											
RAB3GAP2	25782	broad.mit.edu	37	chr1	220340949	220340949	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgcatctctttcttcattagCcagttttaatacttcagggc	6	10	4	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:220340949C>A	uc010puk.1	-	25	3039	c.2875G>T	c.(2875-2877)GCT>TCT	p.A959S	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.A539S|RAB3GAP2_uc001hmh.2_5'Flank	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	959					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		TCTTCATTAGCCAGTTTTAAT	0.398													A	220340949	A	A	220340949	3	1	142	1	0	0	0	0	1	0	0	0	12936	739	26	5	1350	5	RAB3GAP2	1	220340949	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	15028342	220340949	28909672	8	9694											
HHIPL2	79802	broad.mit.edu	37	chr1	222717502	222717502	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctgggtgttttcggcgtcGtagaggtgggctgcgtaggg	20	6	1	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:222717502G>A	uc001hnh.1	-	2	409	c.351C>T	c.(349-351)TAC>TAT	p.Y117Y		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	117					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		TTTCGGCGTCGTAGAGGTGGG	0.567													A	222717502	A	A	222717502	2	1	142	1	0	0	0	0	0	0	0	1	7094	1140	40	1		1	HHIPL2	1	222717502	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08	2376553	222717502	26533119	9	9695											
NUP133	55746	broad.mit.edu	37	chr1	229606471	229606471	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggcggctgacagcttttcGgcatgctcacagagcaacag	12	11	1	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr1:229606471G>A	uc001htn.2	-	15	2024	c.1932C>T	c.(1930-1932)GCC>GCT	p.A644A		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	644					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				ACAGCTTTTCGGCATGCTCAC	0.493													A	229606471	A	A	229606471	2	1	142	1	0	0	0	0	0	0	0	1	10754	1103	39	2		2	NUP133	1	229606471	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08	6888969	229606471	19644150	10	9696											
SPEG	10290	broad.mit.edu	37	chr2	220353375	220353375	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatcaccagctcctgtaccGtggctgtggcccgtgagcct	12	15	1	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr2:220353375G>A	uc010fwg.2	+	33	8014	c.8014G>A	c.(8014-8016)GTG>ATG	p.V2672M		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2672	Ig-like 9.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTCCTGTACCGTGGCTGTGGC	0.672													A	220353375	A	A	220353375	3	1	142	1	0	0	0	0	1	0	0	0	15035	1145	40	1	8156	1	SPEG	2	220353375	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08		220353375	22845998	11	9697											
C2orf85	285093	broad.mit.edu	37	chr2	242814085	242814085	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacatcctgcaggactgctaCggggatggccccggcccagc	13	16	0	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr2:242814085C>T	uc010fzu.1	+	2	401	c.378C>T	c.(376-378)TAC>TAT	p.Y126Y		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	126						integral to membrane				ovary(1)	1						AGGACTGCTACGGGGATGGCC	0.711													T	242814085	T	T	242814085	2	4	142	1	0	0	0	0	0	0	0	1	2200	547	19	1		1	C2orf85	2	242814085	Silent	SNP	C	TCGA-14-1829-01A-01W-0643-08	22460710	242814085	385288	12	9698											
DPPA4	55211	broad.mit.edu	37	chr3	109046838	109046838	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcctttttcctgatattctaTtcccattggaggctttttat	6	9	1	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr3:109046838T>G	uc003dxq.3	-	7	967	c.912A>C	c.(910-912)GAA>GAC	p.E304D	DPPA4_uc011bho.1_3'UTR	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	304						nucleus	protein binding			upper_aerodigestive_tract(1)	1						TGATATTCTATTCCCATTGGA	0.368													G	109046838	G	G	109046838	3	3	142	1	0	0	0	0	1	0	0	0	4736	1490	52	5	6	5	DPPA4	3	109046838	Missense_Mutation	SNP	T	TCGA-14-1829-01A-01W-0643-08		109046838	88975592	13	9699											
HCLS1	3059	broad.mit.edu	37	chr3	121356079	121356079	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatccttctccaccccgtacCggccaccaaagccacgagag	7	18	1	1	rs142478875	by1000genomes	TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr3:121356079C>T	uc003eeh.3	-	7	604	c.479G>A	c.(478-480)CGG>CAG	p.R160Q	HCLS1_uc011bjj.1_Intron|HCLS1_uc011bjk.1_RNA	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	160	Cortactin 3.				erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		CACCCCGTACCGGCCACCAAA	0.557													T	121356079	T	T	121356079	3	4	142	1	0	0	0	0	1	0	0	0	6995	652	23	2	1013	2	HCLS1	3	121356079	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	12309241	121356079	76666351	14	9700											
SR140	23350	broad.mit.edu	37	chr3	142741859	142741859	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagagcggttaaaaaaccctAatgctcctatgttaccgcca	8	11	0	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr3:142741859A>G	uc003evh.1	+	12	1282	c.1183A>G	c.(1183-1185)AAT>GAT	p.N395D	SR140_uc003evi.1_5'UTR|SR140_uc011bnj.1_Missense_Mutation_p.N395D|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.N394D|SR140_uc003evl.1_5'Flank	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	395	Pro-rich.				RNA processing	nucleus	nucleotide binding|RNA binding				0						AAAAAACCCTAATGCTCCTAT	0.418													G	142741859	G	G	142741859	3	3	142	1	0	0	0	0	1	0	0	0	15130	362	13	4	1229	4	SR140	3	142741859	Missense_Mutation	SNP	A	TCGA-14-1829-01A-01W-0643-08	21385780	142741859	55280571	15	9701											
SLIT2	9353	broad.mit.edu	37	chr4	20544133	20544133	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttaggaaatgatgacaatagTtgctccccactttctcgctg	8	10	1	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr4:20544133T>C	uc003gpr.1	+	21	2364	c.2160T>C	c.(2158-2160)AGT>AGC	p.S720S	SLIT2_uc003gps.1_Silent_p.S712S	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	720	LRRNT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATGACAATAGTTGCTCCCCAC	0.413													C	20544133	C	C	20544133	2	2	142	1	0	0	0	0	0	0	0	1	14740	1722	60	4		4	SLIT2	4	20544133	Silent	SNP	T	TCGA-14-1829-01A-01W-0643-08		20544133	170610143	16	9702											
PKD2	5311	broad.mit.edu	37	chr4	88973158	88973158	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcagctgtcagtggtagctAtaggaattaacatatacaga	9	6	2	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr4:88973158A>G	uc003hre.2	+	7	1630	c.1564A>G	c.(1564-1566)ATA>GTA	p.I522V	PKD2_uc011cdf.1_5'UTR|PKD2_uc011cdg.1_5'UTR|PKD2_uc011cdh.1_5'UTR	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	522	Helical; (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		AGTGGTAGCTATAGGAATTAA	0.323													G	88973158	G	G	88973158	3	3	142	1	0	0	0	0	1	0	0	0	11966	449	16	4	1590	4	PKD2	4	88973158	Missense_Mutation	SNP	A	TCGA-14-1829-01A-01W-0643-08	68429025	88973158	102181118	17	9703											
GPR98	84059	broad.mit.edu	37	chr5	90055389	90055389	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ttctccatttggagtatttgGatttgaagaaaagactgtaa	9	4	1	3			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr5:90055389G>T	uc003kju.2	+	58	12200	c.12104G>T	c.(12103-12105)GGA>GTA	p.G4035V	GPR98_uc003kjt.2_Missense_Mutation_p.G1741V|GPR98_uc003kjv.2_Missense_Mutation_p.G1635V	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4035	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGAGTATTTGGATTTGAAGAA	0.368													T	90055389	T	T	90055389	3	4	142	1	0	0	0	0	1	0	0	0	6721	1174	41	5	12334	5	GPR98	5	90055389	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08		90055389	90859871	18	9704											
ETF1	2107	broad.mit.edu	37	chr5	137846888	137846888	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgatttcatcaaagtatcgTcctacgattagggatcagtc	8	9	3	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr5:137846888T>C	uc003ldc.3	-	8	1029	c.864A>G	c.(862-864)GGA>GGG	p.G288G	ETF1_uc011cyv.1_Silent_p.G274G|ETF1_uc010jex.2_RNA|ETF1_uc003ldd.3_Silent_p.G255G	NM_004730	NP_004721	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	288					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CAAAGTATCGTCCTACGATTA	0.368													C	137846888	C	C	137846888	2	2	142	1	0	0	0	0	0	0	0	1	5268	1681	58	4		4	ETF1	5	137846888	Silent	SNP	T	TCGA-14-1829-01A-01W-0643-08	47791499	137846888	43068372	19	9705											
PCDHB6	56130	broad.mit.edu	37	chr5	140530986	140530986	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaacaggttatttgttcaaTagagaacaatctcccctttc	5	11	2	1	rs142117819	by1000genomes	TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr5:140530986T>C	uc003lir.2	+	1	1148	c.1148T>C	c.(1147-1149)ATA>ACA	p.I383T	PCDHB6_uc011dah.1_Missense_Mutation_p.I247T	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	383	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTTGTTCAATAGAGAACAAT	0.463													C	140530986	C	C	140530986	3	2	142	1	0	0	0	0	1	0	0	0	11546	1406	49	4	1150	4	PCDHB6	5	140530986	Missense_Mutation	SNP	T	TCGA-14-1829-01A-01W-0643-08	2684098	140530986	40384274	20	9706											
PCDHB7	56129	broad.mit.edu	37	chr5	140554290	140554290	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgcacaatggcgaggtgcGtaccgccaggctgctgagcg	17	12	0	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr5:140554290G>A	uc003lit.2	+	1	2048	c.1874G>A	c.(1873-1875)CGT>CAT	p.R625H		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	625	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGAGGTGCGTACCGCCAGG	0.697													A	140554290	A	A	140554290	3	1	142	1	0	0	0	0	1	0	0	0	11547	1145	40	1	1876	1	PCDHB7	5	140554290	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08	23304	140554290	40360970	21	9707											
TREML1	340205	broad.mit.edu	37	chr6	41121804	41121804	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggtgcctgcagcacctcaGggaggctgccaactatgccc	13	15	1	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr6:41121804G>A	uc011duc.1	-	2	112	c.68C>T	c.(67-69)CCT>CTT	p.P23L	TREML1_uc003opx.2_Missense_Mutation_p.P23L|TREML1_uc011dud.1_Intron	NM_178174	NP_835468	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid	23	Ig-like V-type.|Extracellular (Potential).				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					CAGCACCTCAGGGAGGCTGCC	0.607													A	41121804	A	A	41121804	3	1	142	1	0	0	0	0	1	0	0	0	16469	1000	35	3	885	3	TREML1	6	41121804	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08		41121804	129993263	22	9708											
GFRAL	389400	broad.mit.edu	37	chr6	55196594	55196594	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagcaatgcttacgtgatgCaaatggatgtaaacatgctt	10	6	0	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr6:55196594C>T	uc003pcm.1	+	2	190	c.104C>T	c.(103-105)GCA>GTA	p.A35V		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	35	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTACGTGATGCAAATGGATGT	0.338													T	55196594	T	T	55196594	3	4	142	1	0	0	0	0	1	0	0	0	6351	710	25	3	110	3	GFRAL	6	55196594	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	14074790	55196594	115918473	23	9709											
BCLAF1	9774	broad.mit.edu	37	chr6	136599627	136599627	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctagaagatctatatgacCggcgagatctgcttctggat	10	9	3	4	rs149799182		TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr6:136599627C>T	uc003qgx.1	-	4	645	c.392G>A	c.(391-393)CGG>CAG	p.R131Q	BCLAF1_uc003qgw.1_Missense_Mutation_p.R131Q|BCLAF1_uc003qgy.1_Missense_Mutation_p.R129Q|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R129Q	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	131					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCTATATGACCGGCGAGATCT	0.448													T	136599627	T	T	136599627	3	4	142	1	0	0	0	0	1	0	0	0	1383	652	23	2	2410	2	BCLAF1	6	136599627	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	81403033	136599627	34515440	24	9710											
USP42	84132	broad.mit.edu	37	chr7	6183728	6183728	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttcaaggtgtaaaaagatGgttccagcttcaaagaggtt	11	5	2	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:6183728G>A	uc011jwo.1	+	9	1014	c.891G>A	c.(889-891)ATG>ATA	p.M297I	USP42_uc011jwn.1_Missense_Mutation_p.M142I|USP42_uc010kth.1_Missense_Mutation_p.M230I|USP42_uc011jwp.1_Missense_Mutation_p.M297I|USP42_uc011jwq.1_Missense_Mutation_p.M104I|USP42_uc011jwr.1_Missense_Mutation_p.M142I	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	297					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		GTAAAAAGATGGTTCCAGCTT	0.333													A	6183728	A	A	6183728	3	1	142	1	0	0	0	0	1	0	0	0	17070	1348	47	3	921	3	USP42	7	6183728	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08		6183728	152954935	25	9711											
URGCP	55665	broad.mit.edu	37	chr7	43917037	43917037	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agctccttcaggagccctgtGacccagcggacgggcatgct	13	14	1	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:43917037G>C	uc003tiw.2	-	6	2082	c.2025C>G	c.(2023-2025)GTC>GTG	p.V675V	URGCP_uc003tiu.2_Silent_p.V632V|URGCP_uc003tiv.2_Silent_p.V600V|URGCP_uc003tix.2_Silent_p.V666V|URGCP_uc003tiy.2_Silent_p.V632V|URGCP_uc003tiz.2_Silent_p.V632V|URGCP_uc011kbj.1_Silent_p.V632V	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	675					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						GGAGCCCTGTGACCCAGCGGA	0.642													C	43917037	C	C	43917037	2	2	142	1	0	0	0	0	0	0	0	1	17023	1277	45	5		5	URGCP	7	43917037	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08	37733309	43917037	115221626	26	9712			1	31		4	4	1732	G		7.604947e-09
URGCP	55665	broad.mit.edu	37	chr7	43917123	43917123	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cagctccgaggccaagcctgGgaagtgggcaaaacgcctct	13	13	1	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:43917123G>T	uc003tiw.2	-	6	1996	c.1939C>A	c.(1939-1941)CCA>ACA	p.P647T	URGCP_uc003tiu.2_Missense_Mutation_p.P604T|URGCP_uc003tiv.2_Missense_Mutation_p.P572T|URGCP_uc003tix.2_Missense_Mutation_p.P638T|URGCP_uc003tiy.2_Missense_Mutation_p.P604T|URGCP_uc003tiz.2_Missense_Mutation_p.P604T|URGCP_uc011kbj.1_Missense_Mutation_p.P604T	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	647					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						GCCAAGCCTGGGAAGTGGGCA	0.622													T	43917123	T	T	43917123	3	4	142	1	0	0	0	0	1	0	0	0	17023	1232	43	5	860	5	URGCP	7	43917123	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08	86	43917123	115221540	27	9713			1	31		4	4	1732	G		7.604947e-09
URGCP	55665	broad.mit.edu	37	chr7	43918034	43918034	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gcttaaactgcagccagtgaGacccgatgtcacctctcagg	10	13	2	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:43918034G>C	uc003tiw.2	-	6	1085	c.1028C>G	c.(1027-1029)TCT>TGT	p.S343C	URGCP_uc003tiu.2_Missense_Mutation_p.S300C|URGCP_uc003tiv.2_Missense_Mutation_p.S268C|URGCP_uc003tix.2_Missense_Mutation_p.S334C|URGCP_uc003tiy.2_Missense_Mutation_p.S300C|URGCP_uc003tiz.2_Missense_Mutation_p.S300C|URGCP_uc011kbj.1_Missense_Mutation_p.S300C	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	343					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						CAGCCAGTGAGACCCGATGTC	0.458													C	43918034	C	C	43918034	3	2	142	1	0	0	0	0	1	0	0	0	17023	942	33	5	1771	5	URGCP	7	43918034	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08	911	43918034	115220629	28	9714			1	31		4	4	1732	G		7.604947e-09
URGCP	55665	broad.mit.edu	37	chr7	43918768	43918768	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttcttcatactgtcaaaactGatctgcagagagtcctggag	9	9	4	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:43918768G>C	uc003tiw.2	-	6	351	c.294C>G	c.(292-294)ATC>ATG	p.I98M	URGCP_uc003tiu.2_Missense_Mutation_p.I55M|URGCP_uc003tiv.2_Missense_Mutation_p.I23M|URGCP_uc003tix.2_Missense_Mutation_p.I89M|URGCP_uc003tiy.2_Missense_Mutation_p.I55M|URGCP_uc003tiz.2_Missense_Mutation_p.I55M|URGCP_uc011kbj.1_Missense_Mutation_p.I55M	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	98					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						TGTCAAAACTGATCTGCAGAG	0.507													C	43918768	C	C	43918768	3	2	142	1	0	0	0	0	1	0	0	0	17023	1280	45	5	2505	5	URGCP	7	43918768	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08	734	43918768	115219895	29	9715			1	31		4	4	1732	G		7.604947e-09
EGFR	1956	broad.mit.edu	37	chr7	55224307	55224307	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taaacacttcaaaaactgcaCctccatcagtggcgatctcc	5	14	3	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:55224307C>T	uc003tqk.2	+	9	1334	c.1088C>T	c.(1087-1089)ACC>ATC	p.T363I	EGFR_uc003tqh.2_Missense_Mutation_p.T363I|EGFR_uc003tqi.2_Missense_Mutation_p.T363I|EGFR_uc003tqj.2_Missense_Mutation_p.T363I|EGFR_uc010kzg.1_Missense_Mutation_p.T318I|EGFR_uc011kco.1_Missense_Mutation_p.T310I|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	363	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AAAAACTGCACCTCCATCAGT	0.413		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55224307	T	T	55224307	3	4	142	1	0	0	0	0	1	0	0	0	4967	507	18	3	1122	3	EGFR	7	55224307	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	11305539	55224307	103914356	30	9716											
NCF1	653361	broad.mit.edu	37	chr7	74193497	74193497	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaacaggatcatcccccacCtcccaggtgagcacggggct	11	15	1	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:74193497C>T	uc003ubb.2	+	3	293	c.223C>T	c.(223-225)CTC>TTC	p.L75F	NCF1_uc010lbs.1_Missense_Mutation_p.L75F|NCF1_uc011kfh.1_Intron	NM_000265	NP_000256	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	75	PX.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			skin(1)	1						CATCCCCCACCTCCCAGGTGA	0.552													T	74193497	T	T	74193497	3	4	142	1	0	0	0	0	1	0	0	0	10216	681	24	3	233	3	NCF1	7	74193497	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	18969190	74193497	84945166	31	9717											
TRIM4	89122	broad.mit.edu	37	chr7	99516656	99516656	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tagctctcgaaggcctcgtcGatgggtgccatggcgtgagt	15	10	1	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:99516656G>A	uc003usd.2	-	1	499	c.369C>T	c.(367-369)ATC>ATT	p.I123I	TRIM4_uc003use.2_Silent_p.I123I|TRIM4_uc011kjc.1_5'UTR|TRIM4_uc003usf.2_Silent_p.I123I	NM_033017	NP_148977	Q9C037	TRIM4_HUMAN	tripartite motif protein TRIM4 isoform alpha	123	B box-type.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			ovary(1)|kidney(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				AGGCCTCGTCGATGGGTGCCA	0.612													A	99516656	A	A	99516656	2	1	142	1	0	0	0	0	0	0	0	1	16511	1048	37	2		2	TRIM4	7	99516656	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08	25323159	99516656	59622007	32	9718											
LHFPL3	375612	broad.mit.edu	37	chr7	103969236	103969237	+	In_Frame_Ins	INS	-	GCC	GCC													ggagggggagaatgcccggaINSgccgccgccgctgccgccgc							TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:103969236_103969237insGCC	uc003vce.2	+	1	133_134	c.9_10insGCC	c.(7-12)insGCC	p.14_15insA	LHFPL3_uc003vcf.2_In_Frame_Ins_p.14_15insA	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	Error:Variant_position_missing_in_Q86UP9_after_alignment_1						integral to membrane					0						gAATGCCCGGAgccgccgccgc	0.396													GCC	103969237	GCC	GCC	103969236	7	5	142	1	0	1	1	0	0	0	0	0	8766	291	11	0	11	0	LHFPL3	7	103969236	In_Frame_Ins	INS	-	TCGA-14-1829-01A-01W-0643-08	4452580	103969236	55169427	33	9719											
PIK3CG	5294	broad.mit.edu	37	chr7	106508126	106508126	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tccatggagctcatccccatCgagttcgtgctgcccaccag	9	16	1	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:106508126C>T	uc003vdv.3	+	2	205	c.120C>T	c.(118-120)ATC>ATT	p.I40I	PIK3CG_uc003vdu.2_Silent_p.I40I|PIK3CG_uc003vdw.2_Silent_p.I40I	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	40					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TCATCCCCATCGAGTTCGTGC	0.662													T	106508126	T	T	106508126	2	4	142	1	0	0	0	0	0	0	0	1	11916	874	31	2		2	PIK3CG	7	106508126	Silent	SNP	C	TCGA-14-1829-01A-01W-0643-08	2538890	106508126	52630537	34	9720											
C7orf66	154907	broad.mit.edu	37	chr7	108524126	108524126	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtttcttgtggacaatccGtagatatgcacctttcactt	8	9	2	1	rs143724624		TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:108524126G>A	uc003vfo.2	-	2	334	c.286C>T	c.(286-288)CGG>TGG	p.R96W		NM_001024607	NP_001019778	A4D0T2	CG066_HUMAN	hypothetical protein LOC154907	96						integral to membrane				ovary(2)	2						TGGACAATCCGTAGATATGCA	0.348													A	108524126	A	A	108524126	3	1	142	1	0	0	0	0	1	0	0	0	2412	1144	40	1	65	1	C7orf66	7	108524126	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08	2016000	108524126	50614537	35	9721											
GPR37	2861	broad.mit.edu	37	chr7	124387325	124387325	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catttcgtagtacatctgtaCgttggtggcagcacggaagc	12	9	1	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:124387325C>T	uc003vli.2	-	2	1747	c.1096G>A	c.(1096-1098)GTA>ATA	p.V366I		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	366	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						TACATCTGTACGTTGGTGGCA	0.463													T	124387325	T	T	124387325	3	4	142	1	0	0	0	0	1	0	0	0	6691	536	19	1	749	1	GPR37	7	124387325	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	15863199	124387325	34751338	36	9722											
AKR1B10	57016	broad.mit.edu	37	chr7	134212671	134212671	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctgcaccaaccatggccaCgtttgtggagctcagtacca	9	13	2	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr7:134212671C>T	uc003vrr.2	+	1	328	c.8C>T	c.(7-9)ACG>ATG	p.T3M		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	3					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						ACCATGGCCACGTTTGTGGAG	0.438													T	134212671	T	T	134212671	3	4	142	1	0	0	0	0	1	0	0	0	467	536	19	1	10	1	AKR1B10	7	134212671	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	9825346	134212671	24925992	37	9723											
EBF2	64641	broad.mit.edu	37	chr8	25718712	25718712	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gacgctgtagagagcttcagCaatgtctgcggctcgcttca	12	11	3	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr8:25718712C>A	uc003xes.1	-	13	1212	c.1195G>T	c.(1195-1197)GCT>TCT	p.A399S	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	399					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		AGAGCTTCAGCAATGTCTGCG	0.493													A	25718712	A	A	25718712	3	1	142	1	0	0	0	0	1	0	0	0	4881	710	25	5	548	5	EBF2	8	25718712	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08		25718712	120645310	38	9724											
LY96	23643	broad.mit.edu	37	chr8	74922304	74922304	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccatgaatcttccaaagcgcAaagaagttatttgccgagga	9	9	1	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr8:74922304A>G	uc003yad.2	+	3	362	c.271A>G	c.(271-273)AAA>GAA	p.K91E		NM_015364	NP_056179	Q9Y6Y9	LY96_HUMAN	MD-2 protein precursor	91					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			TCCAAAGCGCAAAGAAGTTAT	0.343													G	74922304	G	G	74922304	3	3	142	1	0	0	0	0	1	0	0	0	9102	131	5	4	281	4	LY96	8	74922304	Missense_Mutation	SNP	A	TCGA-14-1829-01A-01W-0643-08	49203592	74922304	71441718	39	9725											
TAF2	6873	broad.mit.edu	37	chr8	120831592	120831592	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agtgcataacttactgttttGattcactgtgacaaacttcc	6	9	1	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr8:120831592G>C	uc003you.2	-	3	563	c.293C>G	c.(292-294)TCA>TGA	p.S98*		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	98					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTACTGTTTTGATTCACTGTG	0.289													C	120831592	C	C	120831592	4	2	142	1	0	0	0	0	0	1	0	0	15521	1294	45	5	3402	5	TAF2	8	120831592	Nonsense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08	45909288	120831592	25532430	40	9726											
C9orf131	138724	broad.mit.edu	37	chr9	35045372	35045372	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctggtgtggactatctatctCcaggcccaggagaaccctca	10	13	3	1	rs3739871	byFrequency	TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr9:35045372C>G	uc003zvw.2	+	2	2775	c.2746C>G	c.(2746-2748)CCA>GCA	p.P916A	C9orf131_uc003zvu.2_Missense_Mutation_p.P868A|C9orf131_uc003zvv.2_Missense_Mutation_p.P843A|C9orf131_uc003zvx.2_Missense_Mutation_p.P881A	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	916											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CTATCTATCTCCAGGCCCAGG	0.537													G	35045372	G	G	35045372	3	3	142	1	0	0	0	0	1	0	0	0	2457	855	30	5	2768	5	C9orf131	9	35045372	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08		35045372	106168059	41	9727											
ARHGAP22	58504	broad.mit.edu	37	chr10	49667897	49667897	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggggccatacttccgctcGtggtggactgtttcctctag	13	12	1	0	rs78086414		TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr10:49667897G>A	uc001jgt.2	-	5	786	c.489C>T	c.(487-489)CAC>CAT	p.H163H	ARHGAP22_uc001jgs.2_Silent_p.H73H|ARHGAP22_uc001jgu.2_Silent_p.H179H|ARHGAP22_uc010qgl.1_Silent_p.H120H|ARHGAP22_uc010qgm.1_Silent_p.H169H|ARHGAP22_uc001jgv.2_Translation_Start_Site	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	163	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						ACTTCCGCTCGTGGTGGACTG	0.642													A	49667897	A	A	49667897	2	1	142	1	0	0	0	0	0	0	0	1	872	1136	40	1		1	ARHGAP22	10	49667897	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08		49667897	85866850	42	9728											
TLL2	7093	broad.mit.edu	37	chr10	98156950	98156950	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctcgcacaaaccttcgtaCgctgcaaagaagcccttgcc	7	16	0	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr10:98156950C>T	uc001kml.1	-	11	1603	c.1377G>A	c.(1375-1377)GCG>GCA	p.A459A	TLL2_uc009xvf.1_Silent_p.A437A	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	459	CUB 1.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		AACCTTCGTACGCTGCAAAGA	0.622													T	98156950	T	T	98156950	2	4	142	1	0	0	0	0	0	0	0	1	15943	523	19	1		1	TLL2	10	98156950	Silent	SNP	C	TCGA-14-1829-01A-01W-0643-08	48489053	98156950	37377797	43	9729											
OR4D10	390197	broad.mit.edu	37	chr11	59244963	59244963	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tccttggcctgacccagaatCgggaagtgagcttagtctta	11	10	1	3			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr11:59244963C>T	uc001nnz.1	+	1	61	c.61C>T	c.(61-63)CGG>TGG	p.R21W		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GACCCAGAATCGGGAAGTGAG	0.413													T	59244963	T	T	59244963	3	4	142	1	0	0	0	0	1	0	0	0	11054	875	31	2	63	2	OR4D10	11	59244963	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08		59244963	75761553	44	9730											
PKNOX2	63876	broad.mit.edu	37	chr11	125255470	125255470	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctcttttcccgctcctgaCgctgctgtttgagaaatgtg	9	13	1	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr11:125255470C>T	uc001qbu.2	+	6	565	c.251C>T	c.(250-252)ACG>ATG	p.T84M	PKNOX2_uc010saz.1_Missense_Mutation_p.T55M|PKNOX2_uc010sba.1_Missense_Mutation_p.T55M|PKNOX2_uc010sbb.1_Missense_Mutation_p.T20M	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	84						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CCGCTCCTGACGCTGCTGTTT	0.567													T	125255470	T	T	125255470	3	4	142	1	0	0	0	0	1	0	0	0	11983	536	19	1	261	1	PKNOX2	11	125255470	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	66010507	125255470	9751046	45	9731											
LTBR	4055	broad.mit.edu	37	chr12	6497971	6497971	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattctccattgcaggatcgCtgctcaagaggcgtccgcag	11	13	2	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr12:6497971C>T	uc001qny.1	+	8	949	c.781C>T	c.(781-783)CTG>TTG	p.L261L	LTBR_uc010sfc.1_Silent_p.L242L|LTBR_uc001qnz.1_Silent_p.L256L	NM_002342	NP_002333	P36941	TNR3_HUMAN	lymphotoxin beta receptor precursor	261	Cytoplasmic (Potential).				apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			lung(2)	2						TGCAGGATCGCTGCTCAAGAG	0.562													T	6497971	T	T	6497971	2	4	142	1	0	0	0	0	0	0	0	1	9077	796	28	3		3	LTBR	12	6497971	Silent	SNP	C	TCGA-14-1829-01A-01W-0643-08		6497971	127353924	46	9732											
SLC17A8	246213	broad.mit.edu	37	chr12	100811900	100811900	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaccctctctggaatggtctGtcccctcattgtcggtgcaa	9	13	3	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr12:100811900G>A	uc010svi.1	+	11	1704	c.1391G>A	c.(1390-1392)TGT>TAT	p.C464Y	SLC17A8_uc009ztx.2_Missense_Mutation_p.C414Y	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	464	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						GGAATGGTCTGTCCCCTCATT	0.498													A	100811900	A	A	100811900	3	1	142	1	0	0	0	0	1	0	0	0	14423	1377	48	3	1433	3	SLC17A8	12	100811900	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08	94313929	100811900	33039995	47	9733											
SIAH3	283514	broad.mit.edu	37	chr13	46358034	46358034	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagggcgtcaccgggttggcGtgcagccccgcctcctggtg	16	15	1	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr13:46358034G>A	uc001vap.2	-	2	376	c.294C>T	c.(292-294)CAC>CAT	p.H98H		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	98	SIAH-type; degenerate.|His-rich.				multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						CCGGGTTGGCGTGCAGCCCCG	0.428													A	46358034	A	A	46358034	2	1	142	1	0	0	0	0	0	0	0	1	14301	1136	40	1		1	SIAH3	13	46358034	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08		46358034	68811844	48	9734											
NRXN3	9369	broad.mit.edu	37	chr14	80328137	80328137	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatcttgatcctcctgtacGccatgtacaagtacaggaac	8	12	1	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr14:80328137G>A	uc001xun.2	+	17	3507	c.3016G>A	c.(3016-3018)GCC>ACC	p.A1006T	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.A582T|NRXN3_uc010asw.2_Missense_Mutation_p.A404T|NRXN3_uc001xur.3_Missense_Mutation_p.A377T	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1588	Helical; (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CCTCCTGTACGCCATGTACAA	0.597													A	80328137	A	A	80328137	3	1	142	1	0	0	0	0	1	0	0	0	10667	1087	38	1	3428	1	NRXN3	14	80328137	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08		80328137	27021403	49	9735											
DIO3	1735	broad.mit.edu	37	chr14	102028607	102028607	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcggcctatggcgcctacttCgagcgtctctatgtcatcca	9	14	2	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr14:102028607C>T	uc010txq.1	+	2	920	c.696C>T	c.(694-696)TTC>TTT	p.F232F	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	232	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				GCGCCTACTTCGAGCGTCTCT	0.632													T	102028607	T	T	102028607	2	4	142	1	0	0	0	0	0	0	0	1	4526	883	31	2		2	DIO3	14	102028607	Silent	SNP	C	TCGA-14-1829-01A-01W-0643-08	21700470	102028607	5320933	50	9736											
CEP152	22995	broad.mit.edu	37	chr15	49076318	49076318	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacgagagcaaatgtcttcCtaaatagaaaaaaagttcag	8	6	2	3			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr15:49076318C>T	uc001zwy.2	-	10	1208	c.1174_splice	c.e10-1	p.E392_splice	CEP152_uc001zwz.2_Splice_Site_p.E392_splice|CEP152_uc001zxa.1_Splice_Site_p.E299_splice	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa						centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		AAATGTCTTCCTAAATAGAAA	0.294													T	49076318	T	T	49076318	5	4	142	1	0	0	0	0	0	0	1	0	3248	695	24	3	3859	3	CEP152	15	49076318	Splice_Site	SNP	C	TCGA-14-1829-01A-01W-0643-08		49076318	53455074	51	9737											
SMG1	23049	broad.mit.edu	37	chr16	18853724	18853724	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggactgatttcttcaagaCgcaagatgtaacttgcacgt	9	8	2	3			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr16:18853724C>T	uc002dfm.2	-	40	6635	c.6272G>A	c.(6271-6273)CGT>CAT	p.R2091H	SMG1_uc010bwb.2_Missense_Mutation_p.R1951H|SMG1_uc010bwa.2_Missense_Mutation_p.R822H|SMG1_uc002dfo.3_Missense_Mutation_p.R389H	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2091					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TTCTTCAAGACGCAAGATGTA	0.408													T	18853724	T	T	18853724	3	4	142	1	0	0	0	0	1	0	0	0	14795	536	19	1	4809	1	SMG1	16	18853724	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08		18853724	71501029	52	9738											
FAM83G	644815	broad.mit.edu	37	chr17	18875008	18875008	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctagggggtcctgggaagccGtctttatccctagtccctga	12	12	1	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr17:18875008G>A	uc002guw.2	-	6	2303	c.2136C>T	c.(2134-2136)GAC>GAT	p.D712D	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	712										ovary(1)|central_nervous_system(1)	2						CTGGGAAGCCGTCTTTATCCC	0.622													A	18875008	A	A	18875008	2	1	142	1	0	0	0	0	0	0	0	1	5639	1136	40	1		1	FAM83G	17	18875008	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08		18875008	62320202	53	9739											
KCNJ12	3768	broad.mit.edu	37	chr17	21319359	21319359	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcgcgcagctcatcaagccGcgggtcaccgaggagggcga	16	14	3	0	rs147653221	byFrequency	TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr17:21319359G>A	uc002gyv.1	+	3	1410	c.705G>A	c.(703-705)CCG>CCA	p.P235P		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	235	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TCATCAAGCCGCGGGTCACCG	0.632										Prostate(3;0.18)			A	21319359	A	A	21319359	2	1	142	1	0	0	0	0	0	0	0	1	8046	1074	38	1		1	KCNJ12	17	21319359	Silent	SNP	G	TCGA-14-1829-01A-01W-0643-08	2444351	21319359	59875851	54	9740											
CNTNAP1	8506	broad.mit.edu	37	chr17	40843451	40843451	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tggaccatctgcctgtcactCaggtagtgataggggatacg	13	9	3	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr17:40843451C>A	uc002iay.2	+	15	2482	c.2266C>A	c.(2266-2268)CAG>AAG	p.Q756K	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	756	Extracellular (Potential).|Fibrinogen C-terminal.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GCCTGTCACTCAGGTAGTGAT	0.587													A	40843451	A	A	40843451	3	1	142	1	0	0	0	0	1	0	0	0	3646	827	29	5	2324	5	CNTNAP1	17	40843451	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	19524092	40843451	40351759	55	9741											
METRNL	284207	broad.mit.edu	37	chr17	81042908	81042908	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggatgtacccaacaggtgctCtcatcgttaacctgcggccc	10	14	1	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr17:81042908C>A	uc002kgh.2	+	2	390	c.265C>A	c.(265-267)CTC>ATC	p.L89I	METRNL_uc002kgi.2_Missense_Mutation_p.L7I	NM_001004431	NP_001004431	Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation	89						extracellular region					0	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			AACAGGTGCTCTCATCGTTAA	0.617													A	81042908	A	A	81042908	3	1	142	1	0	0	0	0	1	0	0	0	9489	913	32	5	271	5	METRNL	17	81042908	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	40199457	81042908	152302	56	9742											
METRNL	284207	broad.mit.edu	37	chr17	81042984	81042984	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catcaggtccttcacggactCctcgggggccaatatttatt	9	12	2	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr17:81042984C>T	uc002kgh.2	+	2	466	c.341C>T	c.(340-342)TCC>TTC	p.S114F	METRNL_uc002kgi.2_Missense_Mutation_p.S32F	NM_001004431	NP_001004431	Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation	114						extracellular region					0	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			TTCACGGACTCCTCGGGGGCC	0.592													T	81042984	T	T	81042984	3	4	142	1	0	0	0	0	1	0	0	0	9489	855	30	3	347	3	METRNL	17	81042984	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	76	81042984	152226	57	9743											
MUC16	94025	broad.mit.edu	37	chr19	9026244	9026244	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcctggagccagtgcgacGcatgtcctcctcgtactgca	10	15	0	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr19:9026244G>A	uc002mkp.2	-	14	36946	c.36742C>T	c.(36742-36744)CGT>TGT	p.R12248C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12250	SEA 2.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCAGTGCGACGCATGTCCTCC	0.542													A	9026244	A	A	9026244	3	1	142	1	0	0	0	0	1	0	0	0	9973	1087	38	1	7065	1	MUC16	19	9026244	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08		9026244	50102739	58	9744											
MUC16	94025	broad.mit.edu	37	chr19	9085463	9085463	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcagtgttcaaagtactcgCggctgtattctggggaccat	11	9	3	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr19:9085463C>T	uc002mkp.2	-	1	6556	c.6352G>A	c.(6352-6354)GCG>ACG	p.A2118T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2118	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAAGTACTCGCGGCTGTATTC	0.488													T	9085463	T	T	9085463	3	4	142	1	0	0	0	0	1	0	0	0	9973	768	27	1	37507	1	MUC16	19	9085463	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	59219	9085463	50043520	59	9745											
MAN2B1	4125	broad.mit.edu	37	chr19	12768940	12768940	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cgccaggcccaccagcgcctCcagctggttgcacacctgga	11	18	0	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr19:12768940C>G	uc002mub.2	-	10	1322	c.1246G>C	c.(1246-1248)GAG>CAG	p.E416Q	MAN2B1_uc010dyv.1_Missense_Mutation_p.E415Q	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	416					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						ACCAGCGCCTCCAGCTGGTTG	0.687													G	12768940	G	G	12768940	3	3	142	1	0	0	0	0	1	0	0	0	9216	864	30	5	1849	5	MAN2B1	19	12768940	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	3683477	12768940	46360043	60	9746											
IL12RB1	3594	broad.mit.edu	37	chr19	18171938	18171938	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	aaaggcatccttacctccttCcctccagggaactcaatggc	7	15	1	0			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr19:18171938C>A	uc002nhw.1	-	15	1849	c.1785G>T	c.(1783-1785)GGG>GGT	p.G595G	IL12RB1_uc010xqb.1_Silent_p.G595G|IL12RB1_uc002nhx.1_Silent_p.G635G	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	595	Cytoplasmic (Potential).				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						TTACCTCCTTCCCTCCAGGGA	0.552													A	18171938	A	A	18171938	2	1	142	1	0	0	0	0	0	0	0	1	7626	842	30	5		5	IL12RB1	19	18171938	Silent	SNP	C	TCGA-14-1829-01A-01W-0643-08	5402998	18171938	40957045	61	9747											
MLL4	9757	broad.mit.edu	37	chr19	36212329	36212329	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctccagctgagcctgagcctCgggcagtgggccgcaccaac	13	16	0	2			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr19:36212329C>T	uc010eei.2	+	3	2080	c.2080C>T	c.(2080-2082)CGG>TGG	p.R694W		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	694	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCCTGAGCCTCGGGCAGTGGG	0.642													T	36212329	T	T	36212329	3	4	142	1	0	0	0	0	1	0	0	0	9623	875	31	2	2090	2	MLL4	19	36212329	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	18040391	36212329	22916654	62	9748											
NLRP12	91662	broad.mit.edu	37	chr19	54327194	54327194	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggtccttcctgtttatccGctcaaaggtgctgagagcca	10	12	1	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr19:54327194G>A	uc002qch.3	-	1	455	c.235C>T	c.(235-237)CGG>TGG	p.R79W	NLRP12_uc002qci.3_Missense_Mutation_p.R79W|NLRP12_uc002qcj.3_Missense_Mutation_p.R79W|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.R79W	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	79	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTGTTTATCCGCTCAAAGGTG	0.582													A	54327194	A	A	54327194	3	1	142	1	0	0	0	0	1	0	0	0	10474	1086	38	1	3086	1	NLRP12	19	54327194	Missense_Mutation	SNP	G	TCGA-14-1829-01A-01W-0643-08	18114865	54327194	4801789	63	9749											
LILRB2	10288	broad.mit.edu	37	chr19	54782762	54782762	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actggcccccgtaggagcggCtcacagggcccagggtgaag	16	13	1	1			TCGA-14-1829-01A-01W-0643-08	TCGA-14-1829-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	c69ca476-9e11-4f6e-a4f5-6952f792a580	e73172bd-bb87-4131-901c-5f3eb2117df8	g.chr19:54782762C>G	uc002qfb.2	-	6	1126	c.860G>C	c.(859-861)AGC>ACC	p.S287T	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.S287T|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.S287T|LILRB2_uc010yet.1_Missense_Mutation_p.S171T|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	287	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTAGGAGCGGCTCACAGGGCC	0.647													G	54782762	G	G	54782762	3	3	142	1	0	0	0	0	1	0	0	0	8791	797	28	5	972	5	LILRB2	19	54782762	Missense_Mutation	SNP	C	TCGA-14-1829-01A-01W-0643-08	455568	54782762	4346221	64	9750											
PEX14	5195	broad.mit.edu	37	chr1	10555347	10555347	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcagccaagctctactccagGaagtgaaaatgtgctgcctc	10	12	1	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:10555347G>A	uc001arn.2	+	2	74	c.53G>A	c.(52-54)GGA>GAA	p.G18E	PEX14_uc001arm.1_RNA|PEX14_uc009vmu.1_Missense_Mutation_p.G18E|PEX14_uc009vmv.2_5'UTR|PEX14_uc010oam.1_5'UTR|PEX14_uc010oan.1_Missense_Mutation_p.G18E|PEX14_uc001arl.2_RNA	NM_004565	NP_004556	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	18					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(1)	1	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		TCTACTCCAGGAAGTGAAAAT	0.428											OREG0013090	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	10555347	A	A	10555347	3	1	143	1	0	0	0	0	1	0	0	0	11742	1174	41	3	59	3	PEX14	1	10555347	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08		10555347	238695274	1	9751											
PRAMEF2	65122	broad.mit.edu	37	chr1	12919972	12919972	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaagactctttgcaaactcGttttctccaggtgccatcat	7	11	3	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:12919972G>A	uc001aum.1	+	3	799	c.712G>A	c.(712-714)GTT>ATT	p.V238I		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	238											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTGCAAACTCGTTTTCTCCAG	0.448													A	12919972	A	A	12919972	3	1	143	1	0	0	0	0	1	0	0	0	12435	1145	40	1	718	1	PRAMEF2	1	12919972	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	2364625	12919972	236330649	2	9752											
C1orf173	127254	broad.mit.edu	37	chr1	75055329	75055329	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acttaccaccttcctccaacCcagggagacctgcctttttg	6	16	0	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:75055329C>A	uc001dgg.2	-	12	2381	c.2162G>T	c.(2161-2163)GGG>GTG	p.G721V	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.G515V	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	721	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTCCTCCAACCCAGGGAGACC	0.473													A	75055329	A	A	75055329	3	1	143	1	0	0	0	0	1	0	0	0	2014	623	22	5	2442	5	C1orf173	1	75055329	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	62135357	75055329	174195292	3	9753											
GBP5	115362	broad.mit.edu	37	chr1	89732739	89732739	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atctctcagagtccacactaAgtctgggaagaagctcgcag	10	11	3	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:89732739A>T	uc001dnc.2	-	6	1063	c.526T>A	c.(526-528)TTA>ATA	p.L176I	GBP5_uc001dnd.2_Missense_Mutation_p.L176I|GBP5_uc001dne.1_Missense_Mutation_p.L176I	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	176						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		GTCCACACTAAGTCTGGGAAG	0.493													T	89732739	T	T	89732739	3	4	143	1	0	0	0	0	1	0	0	0	6277	69	3	5	1262	5	GBP5	1	89732739	Missense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08	14677410	89732739	159517882	4	9754											
TCHHL1	126637	broad.mit.edu	37	chr1	152058703	152058703	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcctttctgctgcaggtgcGtttttgctgttcacaaatgc	10	10	2	0	rs150195731	byFrequency	TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:152058703G>A	uc001ezo.1	-	3	1520	c.1455C>T	c.(1453-1455)AAC>AAT	p.N485N		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	485							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CTGCAGGTGCGTTTTTGCTGT	0.478													A	152058703	A	A	152058703	2	1	143	1	0	0	0	0	0	0	0	1	15698	1136	40	1		1	TCHHL1	1	152058703	Silent	SNP	G	TCGA-14-2554-01A-01D-1494-08	62325964	152058703	97191918	5	9755											
RGS21	431704	broad.mit.edu	37	chr1	192321267	192321267	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgaagactttaagaaaaCgaaaaatgcagacaaaattg	8	5	0	4			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:192321267C>T	uc001gsh.2	+	4	353	c.179C>T	c.(178-180)ACG>ATG	p.T60M		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	60	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						TTTAAGAAAACGAAAAATGCA	0.348													T	192321267	T	T	192321267	3	4	143	1	0	0	0	0	1	0	0	0	13304	536	19	1	189	1	RGS21	1	192321267	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	40262564	192321267	56929354	6	9756											
FAM58B	339521	broad.mit.edu	37	chr1	200183231	200183231	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcctgggccctgctgcgggaCagctaccacggggggctgtg	18	13	0	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:200183231C>G	uc009wzi.1	+	1	576	c.540C>G	c.(538-540)GAC>GAG	p.D180E		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	180					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					TGCTGCGGGACAGCTACCACG	0.652													G	200183231	G	G	200183231	3	3	143	1	0	0	0	0	1	0	0	0	5591	477	17	5	542	5	FAM58B	1	200183231	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	7861964	200183231	49067390	7	9757											
KCNH1	3756	broad.mit.edu	37	chr1	211192295	211192295	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtcttcaggtagttcatgcGgataagtttggggtcagaaa	13	6	4	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:211192295G>A	uc001hib.2	-	6	1032	c.862C>T	c.(862-864)CGC>TGC	p.R288C	KCNH1_uc001hic.2_Missense_Mutation_p.R288C	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	288	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TAGTTCATGCGGATAAGTTTG	0.448													A	211192295	A	A	211192295	3	1	143	1	0	0	0	0	1	0	0	0	8031	1116	39	2	2131	2	KCNH1	1	211192295	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	11009064	211192295	38058326	8	9758											
OBSCN	84033	broad.mit.edu	37	chr1	228479711	228479711	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgtggagtggaggaagggGcccgagaacctcagagatgg	18	8	1	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:228479711G>A	uc009xez.1	+	39	10496	c.10452G>A	c.(10450-10452)GGG>GGA	p.G3484G	OBSCN_uc001hsn.2_Silent_p.G3484G|OBSCN_uc001hsq.1_Silent_p.G740G	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3484	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGAGGAAGGGGCCCGAGAACC	0.617													A	228479711	A	A	228479711	2	1	143	1	0	0	0	0	0	0	0	1	10812	1190	42	3		3	OBSCN	1	228479711	Silent	SNP	G	TCGA-14-2554-01A-01D-1494-08	17287416	228479711	20770910	9	9759											
OR2T6	254879	broad.mit.edu	37	chr1	248551519	248551519	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtgatgtatgtgtgctgcGttgcaatgctgctgatcccc	12	10	0	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr1:248551519G>A	uc001iei.1	+	1	610	c.610G>A	c.(610-612)GTT>ATT	p.V204I		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTGTGCTGCGTTGCAATGCT	0.517													A	248551519	A	A	248551519	3	1	143	1	0	0	0	0	1	0	0	0	11029	1145	40	1	612	1	OR2T6	1	248551519	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	20071808	248551519	699102	10	9760											
HK2	3099	broad.mit.edu	37	chr2	75081444	75081444	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accagtatctctaccacatgCgcctctctgatgagaccctc	6	16	2	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr2:75081444C>T	uc002snd.2	+	2	2014	c.88C>T	c.(88-90)CGC>TGC	p.R30C		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	30	Regulatory.	ATP 1 (By similarity).			apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						CTACCACATGCGCCTCTCTGA	0.403													T	75081444	T	T	75081444	3	4	143	1	0	0	0	0	1	0	0	0	7191	768	27	1	94	1	HK2	2	75081444	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08		75081444	168117929	11	9761											
PSD4	23550	broad.mit.edu	37	chr2	113955141	113955141	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgttctgttcctggaacagCgccatggggcaagcgtggct	15	10	1	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr2:113955141C>T	uc002tjc.2	+	13	2570	c.2387C>T	c.(2386-2388)ACG>ATG	p.T796M	PSD4_uc002tjd.2_Missense_Mutation_p.T417M|PSD4_uc002tje.2_Missense_Mutation_p.T767M|PSD4_uc002tjf.2_Missense_Mutation_p.T417M|PSD4_uc002tjg.2_5'UTR|PSD4_uc010yxs.1_Missense_Mutation_p.A27V|PSD4_uc002tjh.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	796	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CCTGGAACAGCGCCATGGGGC	0.552													T	113955141	T	T	113955141	3	4	143	1	0	0	0	0	1	0	0	0	12649	782	27	1	2433	1	PSD4	2	113955141	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	38873697	113955141	129244232	12	9762											
TMEM163	81615	broad.mit.edu	37	chr2	135215640	135215640	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatggtgaggccgatcagaaCgcctatgctgccgtccaggt	13	11	1	2	rs145243913		TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr2:135215640C>T	uc002ttx.2	-	7	838	c.772G>A	c.(772-774)GTT>ATT	p.V258I	TMEM163_uc002tty.2_RNA	NM_030923	NP_112185	Q8TC26	TM163_HUMAN	transmembrane protein 163	258	Helical; (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(221;0.154)		CCGATCAGAACGCCTATGCTG	0.552													T	135215640	T	T	135215640	3	4	143	1	0	0	0	0	1	0	0	0	16075	536	19	1	105	1	TMEM163	2	135215640	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	21260499	135215640	107983733	13	9763											
GALNT13	114805	broad.mit.edu	37	chr2	155102330	155102330	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttaatttctctgcaggaaaaCggttgtctgccctatcattg	8	9	3	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr2:155102330C>T	uc002tyr.3	+	7	1259	c.692C>T	c.(691-693)ACG>ATG	p.T231M	GALNT13_uc002tyt.3_Missense_Mutation_p.T231M|GALNT13_uc010foc.1_Missense_Mutation_p.T50M|GALNT13_uc010fod.2_Translation_Start_Site	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	231	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TGCAGGAAAACGGTTGTCTGC	0.323													T	155102330	T	T	155102330	3	4	143	1	0	0	0	0	1	0	0	0	6211	536	19	1	710	1	GALNT13	2	155102330	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	19886690	155102330	88097043	14	9764											
TTN	7273	broad.mit.edu	37	chr2	179572434	179572434	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ccagccttcaaccactggatCctaattggctcagatccctg	7	15	2	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr2:179572434C>A	uc010zfg.1	-	97	25352	c.25128G>T	c.(25126-25128)AGG>AGT	p.R8376S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R5037S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9303							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCACTGGATCCTAATTGGCT	0.498													A	179572434	A	A	179572434	3	1	143	1	0	0	0	0	1	0	0	0	16732	854	30	5	75721	5	TTN	2	179572434	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	24470104	179572434	63626939	15	9765											
PDE1A	5136	broad.mit.edu	37	chr2	183094871	183094871	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgattaggcaagaaacaggAatctgtggaaagtaataatt	11	3	1	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr2:183094871A>G	uc002uos.2	-	7	669	c.585T>C	c.(583-585)ATT>ATC	p.I195I	PDE1A_uc010zfp.1_Silent_p.I91I|PDE1A_uc002uoq.1_Silent_p.I195I|PDE1A_uc010zfq.1_Silent_p.I195I|PDE1A_uc002uor.2_Silent_p.I179I|PDE1A_uc002uou.2_Silent_p.I161I	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	195	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			AAGAAACAGGAATCTGTGGAA	0.348													G	183094871	G	G	183094871	2	3	143	1	0	0	0	0	0	0	0	1	11633	242	9	4		4	PDE1A	2	183094871	Silent	SNP	A	TCGA-14-2554-01A-01D-1494-08	3522437	183094871	60104502	16	9766											
COL6A3	1293	broad.mit.edu	37	chr2	238277593	238277593	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccccctctgagcctcaggcGccgtatggcgtccagcaccg	11	19	2	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr2:238277593G>A	uc002vwl.2	-	10	4798	c.4513C>T	c.(4513-4515)CGC>TGC	p.R1505C	COL6A3_uc002vwo.2_Missense_Mutation_p.R1299C|COL6A3_uc010znj.1_Missense_Mutation_p.R898C	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1505	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGCCTCAGGCGCCGTATGGCG	0.537													A	238277593	A	A	238277593	3	1	143	1	0	0	0	0	1	0	0	0	3701	1087	38	1	5160	1	COL6A3	2	238277593	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	55182722	238277593	4921780	17	9767											
RBMS3	27303	broad.mit.edu	37	chr3	29985717	29985717	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gattcaatcccaagacaggaTtatgatactccaccagctgt	7	11	1	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr3:29985717T>G	uc003cel.2	+	12	1300	c.1070T>G	c.(1069-1071)ATT>AGT	p.I357S	RBMS3_uc003cek.2_Intron|RBMS3_uc010hfq.2_Intron|RBMS3_uc003cem.2_Missense_Mutation_p.I339S|RBMS3_uc010hfr.2_Intron	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	357						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				CAAGACAGGATTATGATACTC	0.388													G	29985717	G	G	29985717	3	3	143	1	0	0	0	0	1	0	0	0	13150	1493	52	5	1159	5	RBMS3	3	29985717	Missense_Mutation	SNP	T	TCGA-14-2554-01A-01D-1494-08		29985717	168036713	18	9768											
ITIH1	3697	broad.mit.edu	37	chr3	52825916	52825916	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acactgattatatcgtccccGacatcttctgagccctctgg	7	14	3	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr3:52825916G>A	uc003dfs.2	+	22	2749	c.2725G>A	c.(2725-2727)GAC>AAC	p.D909N	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_3'UTR|ITIH1_uc010hmo.1_Missense_Mutation_p.D463N|ITIH1_uc003dfu.2_Missense_Mutation_p.D275N|ITIH3_uc003dfv.2_5'Flank|ITIH3_uc011bek.1_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	909	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TATCGTCCCCGACATCTTCTG	0.607													A	52825916	A	A	52825916	3	1	143	1	0	0	0	0	1	0	0	0	7903	1058	37	2	2811	2	ITIH1	3	52825916	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	22840199	52825916	145196514	19	9769											
MAN2B2	23324	broad.mit.edu	37	chr4	6594914	6594914	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacaggtcaggattttactGgaatggcgtggctgtcttcc	13	9	2	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr4:6594914G>A	uc003gjf.1	+	6	731	c.695G>A	c.(694-696)TGG>TAG	p.W232*	MAN2B2_uc003gje.1_Nonsense_Mutation_p.W232*|MAN2B2_uc011bwf.1_Nonsense_Mutation_p.W232*	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	232					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						GGATTTTACTGGAATGGCGTG	0.353													A	6594914	A	A	6594914	4	1	143	1	0	0	0	0	0	1	0	0	9217	1357	47	3	717	3	MAN2B2	4	6594914	Nonsense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08		6594914	184559362	20	9770											
OCIAD1	54940	broad.mit.edu	37	chr4	48853837	48853837	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttacaggcactattatcaaaAgtcaaaatatgactcaagtg	6	7	3	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr4:48853837A>C	uc003gyo.2	+	7	649	c.392A>C	c.(391-393)AAG>ACG	p.K131T	OCIAD1_uc011bzk.1_RNA|OCIAD1_uc003gyr.2_Missense_Mutation_p.K131T|OCIAD1_uc003gyp.2_Missense_Mutation_p.K131T|OCIAD1_uc003gys.2_Missense_Mutation_p.K131T|OCIAD1_uc003gyq.2_Missense_Mutation_p.K131T|OCIAD1_uc010igk.2_Missense_Mutation_p.K136T	NM_017830	NP_060300	Q9NX40	OCAD1_HUMAN	OCIA domain containing 1 isoform 1	131						endosome	protein binding				0						TATTATCAAAAGTCAAAATAT	0.333													C	48853837	C	C	48853837	3	2	143	1	0	0	0	0	1	0	0	0	10817	72	3	5	433	5	OCIAD1	4	48853837	Missense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08	42258923	48853837	142300439	21	9771											
C4orf35	85438	broad.mit.edu	37	chr4	71201726	71201726	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaatccagatatgacttcGttgtccctgcatcaatagct	7	10	1	3	rs139939232		TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr4:71201726G>A	uc003hff.2	+	1	1056	c.970G>A	c.(970-972)GTT>ATT	p.V324I		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	324						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				ATATGACTTCGTTGTCCCTGC	0.413													A	71201726	A	A	71201726	3	1	143	1	0	0	0	0	1	0	0	0	2265	1145	40	1	972	1	C4orf35	4	71201726	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	22347889	71201726	119952550	22	9772											
ENAM	10117	broad.mit.edu	37	chr4	71507774	71507774	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatatcatggctttgggggtCgccctccttattattcagaa	10	9	2	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr4:71507774C>T	uc011caw.1	+	9	912	c.631C>T	c.(631-633)CGC>TGC	p.R211C		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	211					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			CTTTGGGGGTCGCCCTCCTTA	0.398													T	71507774	T	T	71507774	3	4	143	1	0	0	0	0	1	0	0	0	5112	884	31	2	661	2	ENAM	4	71507774	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	306048	71507774	119646502	23	9773											
AFP	174	broad.mit.edu	37	chr4	74310789	74310789	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tagtcctggatgtggcccatGtacatgagcactgttgcaga	12	9	0	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr4:74310789G>T	uc003hgz.1	+	7	840	c.793G>T	c.(793-795)GTA>TTA	p.V265L	AFP_uc003hha.1_Missense_Mutation_p.V265L|AFP_uc011cbg.1_Missense_Mutation_p.V39L	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	265	Albumin 2.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGTGGCCCATGTACATGAGCA	0.388									Alpha-Fetoprotein_Hereditary_Persistence_of				T	74310789	T	T	74310789	3	4	143	1	0	0	0	0	1	0	0	0	363	1377	48	5	819	5	AFP	4	74310789	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	2803015	74310789	116843487	24	9774											
IRF2	3660	broad.mit.edu	37	chr4	185310216	185310216	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctcttccgccagtgtggcCgcccctttcaagaaagtaat	8	14	2	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr4:185310216C>T	uc003iwf.3	-	9	946	c.746G>A	c.(745-747)CGG>CAG	p.R249Q		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	249					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		CCAGTGTGGCCGCCCCTTTCA	0.418													T	185310216	T	T	185310216	3	4	143	1	0	0	0	0	1	0	0	0	7828	652	23	2	307	2	IRF2	4	185310216	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	110999427	185310216	5844060	25	9775											
RAD50	10111	broad.mit.edu	37	chr5	131927096	131927096	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggagatgctgaccaaagacAaagtatgatttttctttttg	9	5	1	4			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr5:131927096A>G	uc003kxi.2	+	10	2020	c.1633A>G	c.(1633-1635)AAA>GAA	p.K545E	RAD50_uc003kxh.2_Missense_Mutation_p.K406E	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	545	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACCAAAGACAAAGTATGATT	0.378								Homologous_recombination					G	131927096	G	G	131927096	3	3	143	1	0	0	0	0	1	0	0	0	12984	131	5	4	1671	4	RAD50	5	131927096	Missense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08		131927096	48988164	26	9776											
HIST1H2AA	221613	broad.mit.edu	37	chr6	25726546	25726546	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttttttgttatcgcgagaCgcattgcctgccagctcaag	10	10	1	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr6:25726546C>T	uc003nfc.2	-	1	245	c.210G>A	c.(208-210)GCG>GCA	p.A70A	HIST1H2BA_uc003nfd.2_5'Flank	NM_170745	NP_734466	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	70					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TATCGCGAGACGCATTGCCTG	0.522													T	25726546	T	T	25726546	2	4	143	1	0	0	0	0	0	0	0	1	7128	523	19	1		1	HIST1H2AA	6	25726546	Silent	SNP	C	TCGA-14-2554-01A-01D-1494-08		25726546	145388521	27	9777											
C2	717	broad.mit.edu	37	chr6	31901972	31901972	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgtaaaatccaaatccagCgctctggtcatctgaacctc	7	14	3	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr6:31901972C>T	uc003nyf.2	+	6	1009	c.745C>T	c.(745-747)CGC>TGC	p.R249C	C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_Intron|C2_uc003nye.3_Missense_Mutation_p.R249C|C2_uc010jtk.2_Missense_Mutation_p.R117C|C2_uc011doq.1_Missense_Mutation_p.R220C|C2_uc003nyg.2_Intron|CFB_uc011dor.1_Intron|C2_uc003nyh.1_5'Flank	NM_000063	NP_000054	P06681	CO2_HUMAN	complement component 2 isoform 1 preproprotein	249				R -> S (in Ref. 7; AA sequence).	complement activation, classical pathway|innate immune response|proteolysis	extracellular space	serine-type endopeptidase activity			ovary(1)|skin(1)	2		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		CCAAATCCAGCGCTCTGGTCA	0.547													T	31901972	T	T	31901972	3	4	143	1	0	0	0	0	1	0	0	0	2074	768	27	1	844	1	C2	6	31901972	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	6175426	31901972	139213095	28	9778											
PPP2R5D	5528	broad.mit.edu	37	chr6	42976451	42976451	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctggcatactgtgtggtacaAttcctggagaaggagagcag	14	7	0	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr6:42976451A>G	uc003oth.2	+	10	1133	c.1047A>G	c.(1045-1047)CAA>CAG	p.Q349Q	MEA1_uc010jyc.1_Intron|PPP2R5D_uc003otg.2_Silent_p.Q317Q|PPP2R5D_uc010jyd.2_Silent_p.Q243Q|PPP2R5D_uc011dva.1_Silent_p.Q198Q|PPP2R5D_uc003oti.2_Silent_p.Q198Q|PPP2R5D_uc003otj.2_Intron	NM_006245	NP_006236	Q14738	2A5D_HUMAN	delta isoform of regulatory subunit B56, protein	349					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(1)|central_nervous_system(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GTGTGGTACAATTCCTGGAGA	0.527													G	42976451	G	G	42976451	2	3	143	1	0	0	0	0	0	0	0	1	12395	98	4	4		4	PPP2R5D	6	42976451	Silent	SNP	A	TCGA-14-2554-01A-01D-1494-08	11074479	42976451	128138616	29	9779											
SUPT3H	8464	broad.mit.edu	37	chr6	44988338	44988338	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtgattacccttgctcccCgcagctgagaaacttcagca	9	13	1	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr6:44988338C>T	uc003oxo.2	-	6	569	c.251G>A	c.(250-252)CGG>CAG	p.R84Q	SUPT3H_uc003oxn.1_Missense_Mutation_p.R73Q|SUPT3H_uc011dvv.1_5'UTR|SUPT3H_uc003oxp.2_Missense_Mutation_p.R73Q|SUPT3H_uc011dvw.1_5'UTR	NM_181356	NP_852001	O75486	SUPT3_HUMAN	suppressor of Ty 3 homolog isoform 2	155					histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			ovary(2)|breast(1)	3						CCTTGCTCCCCGCAGCTGAGA	0.318													T	44988338	T	T	44988338	3	4	143	1	0	0	0	0	1	0	0	0	15394	652	23	2	767	2	SUPT3H	6	44988338	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	2011887	44988338	126126729	30	9780											
STXBP5	134957	broad.mit.edu	37	chr6	147631323	147631323	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gcactgctgtgctagaaatgGactattcaattgttgatttt	9	6	1	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr6:147631323G>T	uc003qlz.2	+	10	1182	c.1021G>T	c.(1021-1023)GAC>TAC	p.D341Y	STXBP5_uc010khz.1_Missense_Mutation_p.D341Y|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.D12Y	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	341					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		GCTAGAAATGGACTATTCAAT	0.368													T	147631323	T	T	147631323	3	4	143	1	0	0	0	0	1	0	0	0	15355	1174	41	5	1059	5	STXBP5	6	147631323	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	102642985	147631323	23483744	31	9781											
CDK13	8621	broad.mit.edu	37	chr7	40039057	40039057	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatcggaattattggagaaGgtacttacggacaagtttac	10	6	1	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr7:40039057G>A	uc003thh.3	+	4	2422	c.2140G>A	c.(2140-2142)GGT>AGT	p.G714S	CDK13_uc003thi.3_Missense_Mutation_p.G714S|CDK13_uc011kbf.1_Missense_Mutation_p.G100S	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	714	Protein kinase.|ATP (By similarity).				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						TATTGGAGAAGGTACTTACGG	0.413													A	40039057	A	A	40039057	3	1	143	1	0	0	0	0	1	0	0	0	3129	1000	35	3	2154	3	CDK13	7	40039057	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08		40039057	119099606	32	9782											
POM121L12	285877	broad.mit.edu	37	chr7	53104173	53104173	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catctgggacttctgggaggCgacaacgccttcctgcggca	13	13	2	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr7:53104173C>T	uc003tpz.2	+	1	825	c.809C>T	c.(808-810)GCG>GTG	p.A270V		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	270											0						TTCTGGGAGGCGACAACGCCT	0.632													T	53104173	T	T	53104173	3	4	143	1	0	0	0	0	1	0	0	0	12241	768	27	1	811	1	POM121L12	7	53104173	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	13065116	53104173	106034490	33	9783											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	143	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	2128870	55233043	103905620	34	9784											
CYP3A4	1576	broad.mit.edu	37	chr7	99366124	99366124	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgctgtaggccccaaagaCgctgagtggagaaagatgtg	14	8	0	4			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr7:99366124C>T	uc003urv.1	-	7	627	c.523G>A	c.(523-525)GTC>ATC	p.V175I	CYP3A4_uc003urw.1_Missense_Mutation_p.V175I|CYP3A4_uc011kiz.1_Missense_Mutation_p.V134I|CYP3A4_uc011kja.1_Missense_Mutation_p.V126I|CYP3A4_uc011kjb.1_Missense_Mutation_p.V25I	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	175					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	GCCCCAAAGACGCTGAGTGGA	0.448													T	99366124	T	T	99366124	3	4	143	1	0	0	0	0	1	0	0	0	4178	550	19	1	1016	1	CYP3A4	7	99366124	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	44133081	99366124	59772539	35	9785											
SH2B2	10603	broad.mit.edu	37	chr7	101943880	101943880	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcagccgccccggtcccaGtcccggtcccggtcccggac	12	22	0	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr7:101943880G>A	uc011kko.1	+	2	220	c.175G>A	c.(175-177)GTC>ATC	p.V59I		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	16					blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						cccggtcccagtcccggtccc	0.473													A	101943880	A	A	101943880	3	1	143	1	0	0	0	0	1	0	0	0	14228	1029	36	3	181	3	SH2B2	7	101943880	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	2577756	101943880	57194783	36	9786											
C7orf66	154907	broad.mit.edu	37	chr7	108524569	108524569	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agttgagaaagaccatcactGggtgtcatcacagccatcat	9	10	4	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr7:108524569G>T	uc003vfo.2	-	1	69	c.21C>A	c.(19-21)CCC>CCA	p.P7P		NM_001024607	NP_001019778	A4D0T2	CG066_HUMAN	hypothetical protein LOC154907	7						integral to membrane				ovary(2)	2						GACCATCACTGGGTGTCATCA	0.408													T	108524569	T	T	108524569	2	4	143	1	0	0	0	0	0	0	0	1	2412	1335	47	5		5	C7orf66	7	108524569	Silent	SNP	G	TCGA-14-2554-01A-01D-1494-08	6580689	108524569	50614094	37	9787											
ABP1	26	broad.mit.edu	37	chr7	150554147	150554147	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggtgtggcttctggccagCgccgcagttggcttatcata	15	10	2	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr7:150554147C>T	uc003why.1	+	3	4807	c.589C>T	c.(589-591)CGC>TGC	p.R197C	ABP1_uc003whz.1_Missense_Mutation_p.R197C|ABP1_uc003wia.1_Missense_Mutation_p.R197C	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	197					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	TTCTGGCCAGCGCCGCAGTTG	0.577													T	150554147	T	T	150554147	3	4	143	1	0	0	0	0	1	0	0	0	98	768	27	1	591	1	ABP1	7	150554147	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	42029578	150554147	8584516	38	9788											
TM7SF4	81501	broad.mit.edu	37	chr8	105361359	105361359	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aatgacagcaaaggggaagtCctgagcgtcttgtaccagat	12	8	1	3			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr8:105361359C>T	uc003ylx.1	+	2	628	c.579C>T	c.(577-579)GTC>GTT	p.V193V		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	193					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAGGGGAAGTCCTGAGCGTCT	0.527													T	105361359	T	T	105361359	2	4	143	1	0	0	0	0	0	0	0	1	15973	842	30	3		3	TM7SF4	8	105361359	Silent	SNP	C	TCGA-14-2554-01A-01D-1494-08		105361359	41002663	39	9789											
MAPK15	225689	broad.mit.edu	37	chr8	144801639	144801639	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcctggagaccatcccaccGccatctgaggagggtgagcc	12	14	1	3			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr8:144801639G>A	uc003yzj.2	+	7	749	c.708G>A	c.(706-708)CCG>CCA	p.P236P		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	236	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCATCCCACCGCCATCTGAGG	0.662													A	144801639	A	A	144801639	2	1	143	1	0	0	0	0	0	0	0	1	9277	1074	38	1		1	MAPK15	8	144801639	Silent	SNP	G	TCGA-14-2554-01A-01D-1494-08	39440280	144801639	1562383	40	9790											
ELAVL2	1993	broad.mit.edu	37	chr9	23701591	23701591	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaatcgaataaaccctacacCccttgatatgcctatggtag	6	11	0	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr9:23701591C>A	uc003zpu.2	-	5	774	c.499G>T	c.(499-501)GGT>TGT	p.G167C	ELAVL2_uc003zps.2_Missense_Mutation_p.G167C|ELAVL2_uc003zpt.2_Missense_Mutation_p.G167C|ELAVL2_uc003zpv.2_Missense_Mutation_p.G167C|ELAVL2_uc003zpw.2_Missense_Mutation_p.G167C	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	167	RRM 2.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding	p.G167D(1)		ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		AACCCTACACCCCTTGATATG	0.443													A	23701591	A	A	23701591	3	1	143	1	0	0	0	0	1	0	0	0	5050	623	22	5	592	5	ELAVL2	9	23701591	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08		23701591	117511840	41	9791											
TMEM215	401498	broad.mit.edu	37	chr9	32784490	32784490	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accccttcagacctagaatcCggcaaggggagctcagatga	11	12	2	4			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr9:32784490C>T	uc003zri.3	+	2	674	c.309C>T	c.(307-309)TCC>TCT	p.S103S		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	103						integral to membrane					0						ACCTAGAATCCGGCAAGGGGA	0.602													T	32784490	T	T	32784490	2	4	143	1	0	0	0	0	0	0	0	1	16135	639	23	2		2	TMEM215	9	32784490	Silent	SNP	C	TCGA-14-2554-01A-01D-1494-08	9082899	32784490	108428941	42	9792											
BSPRY	54836	broad.mit.edu	37	chr9	116122968	116122968	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagaaacttgacaccatccGcactggcctggtgggcatgc	12	13	0	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr9:116122968G>A	uc004bhg.3	+	3	530	c.482G>A	c.(481-483)CGC>CAC	p.R161H	BSPRY_uc010muw.2_Missense_Mutation_p.R161H	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	161					calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						GACACCATCCGCACTGGCCTG	0.602													A	116122968	A	A	116122968	3	1	143	1	0	0	0	0	1	0	0	0	1532	1087	38	1	492	1	BSPRY	9	116122968	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	83338478	116122968	25090463	43	9793											
EGR2	1959	broad.mit.edu	37	chr10	64573353	64573353	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcagagcgggagaaccgccGgtcgcagccttctgctgggc	16	13	2	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr10:64573353G>A	uc010qim.1	-	3	1199	c.1045C>T	c.(1045-1047)CGG>TGG	p.R349W	EGR2_uc010qin.1_Missense_Mutation_p.R299W|EGR2_uc001jmi.2_Missense_Mutation_p.R349W|EGR2_uc010qio.1_Missense_Mutation_p.R362W|EGR2_uc009xph.2_Missense_Mutation_p.R349W	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	349	C2H2-type 1.				fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GAGAACCGCCGGTCGCAGCCT	0.642													A	64573353	A	A	64573353	3	1	143	1	0	0	0	0	1	0	0	0	4972	1115	39	2	389	2	EGR2	10	64573353	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08		64573353	70961394	44	9794											
PCGF5	84333	broad.mit.edu	37	chr10	93038067	93038067	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tatcgaccaagaattgatttCggttagaccaaggggcccag	11	9	0	3			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr10:93038067C>T	uc001khh.2	+	10	1012	c.765C>T	c.(763-765)TTC>TTT	p.F255F	PCGF5_uc010qnk.1_Silent_p.F255F|PCGF5_uc001khi.2_Silent_p.F255F	NM_032373	NP_115749	Q86SE9	PCGF5_HUMAN	polycomb group ring finger 5	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|PcG protein complex	zinc ion binding			lung(1)	1						GAATTGATTTCGGTTAGACCA	0.388													T	93038067	T	T	93038067	2	4	143	1	0	0	0	0	0	0	0	1	11577	883	31	2		2	PCGF5	10	93038067	Silent	SNP	C	TCGA-14-2554-01A-01D-1494-08	28464714	93038067	42496680	45	9795											
OR5D13	390142	broad.mit.edu	37	chr11	55541269	55541269	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaaactttcatgttagcagCgatggcttatgaccgttttg	10	7	1	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr11:55541269C>T	uc010ril.1	+	1	356	c.356C>T	c.(355-357)GCG>GTG	p.A119V		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				ATGTTAGCAGCGATGGCTTAT	0.423													T	55541269	T	T	55541269	3	4	143	1	0	0	0	0	1	0	0	0	11154	768	27	1	358	1	OR5D13	11	55541269	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08		55541269	79465247	46	9796											
OR5M9	390162	broad.mit.edu	37	chr11	56230864	56230864	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtaaattctgtcacatccGtgaaattaggcattgcctta	8	8	2	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr11:56230864G>A	uc010rjj.1	-	1	14	c.14C>T	c.(13-15)ACG>ATG	p.T5M		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T5T(1)		skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TGTCACATCCGTGAAATTAGG	0.408													A	56230864	A	A	56230864	3	1	143	1	0	0	0	0	1	0	0	0	11177	1145	40	1	920	1	OR5M9	11	56230864	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	689595	56230864	78775652	47	9797											
C11orf84	144097	broad.mit.edu	37	chr11	63585590	63585590	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgtgagagctgagcagccGtccccacccaactcaggtag	12	14	1	2	rs114963373	by1000genomes	TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr11:63585590G>A	uc001nxt.2	+	2	677	c.441G>A	c.(439-441)CCG>CCA	p.P147P		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	147	Pro-rich.										0						CTGAGCAGCCGTCCCCACCCA	0.587													A	63585590	A	A	63585590	2	1	143	1	0	0	0	0	0	0	0	1	1667	1132	40	1		1	C11orf84	11	63585590	Silent	SNP	G	TCGA-14-2554-01A-01D-1494-08	7354726	63585590	71420926	48	9798											
CAPN1	823	broad.mit.edu	37	chr11	64950650	64950650	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atggagctacccgcacagacAtctgccagggagcactgggt	13	12	1	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr11:64950650A>G	uc009yqd.1	+	3	430	c.319A>G	c.(319-321)ATC>GTC	p.I107V	uc001ode.2_5'Flank|CAPN1_uc001odf.1_Missense_Mutation_p.I107V|CAPN1_uc001odg.1_Missense_Mutation_p.I107V|CAPN1_uc010roa.1_Intron	NM_005186	NP_005177	P07384	CAN1_HUMAN	calpain 1, large subunit	107	Calpain catalytic.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		CCGCACAGACATCTGCCAGGG	0.602													G	64950650	G	G	64950650	3	3	143	1	0	0	0	0	1	0	0	0	2622	217	8	4	325	4	CAPN1	11	64950650	Missense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08	1365060	64950650	70055866	49	9799											
CABP2	51475	broad.mit.edu	37	chr11	67287267	67287267	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtgcggcagggggtaccttCgaagtcgaccagaccgtccc	14	13	0	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr11:67287267C>T	uc001omc.1	-	6	736	c.634G>A	c.(634-636)GAA>AAA	p.E212K	CABP2_uc001omd.1_Missense_Mutation_p.E155K|CABP2_uc001ome.1_Missense_Mutation_p.E218K	NM_016366	NP_057450	Q9NPB3	CABP2_HUMAN	calcium binding protein 2 isoform 1	212	EF-hand 4.|3 (Potential).				signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1						GGGGTACCTTCGAAGTCGACC	0.572													T	67287267	T	T	67287267	3	4	143	1	0	0	0	0	1	0	0	0	2532	893	31	2	36	2	CABP2	11	67287267	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	2336617	67287267	67719249	50	9800											
ALDH3B2	222	broad.mit.edu	37	chr11	67433035	67433035	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gttggccacggtctgggggtCgcagttgtcgtccacgtagc	16	11	1	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr11:67433035C>T	uc001omr.2	-	7	866	c.427G>A	c.(427-429)GAC>AAC	p.D143N	ALDH3B2_uc001oms.2_Missense_Mutation_p.D143N|ALDH3B2_uc009ysa.1_Missense_Mutation_p.D143N	NM_000695	NP_000686	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3B2	143					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			lung(1)|kidney(1)	2					NADH(DB00157)	GTCTGGGGGTCGCAGTTGTCG	0.637													T	67433035	T	T	67433035	3	4	143	1	0	0	0	0	1	0	0	0	500	884	31	2	746	2	ALDH3B2	11	67433035	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	145768	67433035	67573481	51	9801											
CLEC4D	338339	broad.mit.edu	37	chr12	8672917	8672917	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcgttgggtggaccagacGccatttaacccacgcagagt	13	11	0	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr12:8672917G>A	uc001qun.2	+	5	673	c.480G>A	c.(478-480)ACG>ACA	p.T160T		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	160	C-type lectin.|Extracellular (Potential).				innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					TGGACCAGACGCCATTTAACC	0.423													A	8672917	A	A	8672917	2	1	143	1	0	0	0	0	0	0	0	1	3514	1074	38	1		1	CLEC4D	12	8672917	Silent	SNP	G	TCGA-14-2554-01A-01D-1494-08		8672917	125178978	52	9802											
TRHDE	29953	broad.mit.edu	37	chr12	73015443	73015443	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagaactacgtagagaagttAtaatgctggcctgcagtttt	11	6	0	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr12:73015443A>G	uc001sxa.2	+	15	2482	c.2452A>G	c.(2452-2454)ATA>GTA	p.I818V		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	818	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TAGAGAAGTTATAATGCTGGC	0.363													G	73015443	G	G	73015443	3	3	143	1	0	0	0	0	1	0	0	0	16476	449	16	4	2510	4	TRHDE	12	73015443	Missense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08	64342526	73015443	60836452	53	9803											
CCDC60	160777	broad.mit.edu	37	chr12	119968731	119968731	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctaaagaacttccgccccGccaaaaagatcctggtgaaa	7	12	1	3			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr12:119968731G>A	uc001txe.2	+	13	1879	c.1414G>A	c.(1414-1416)GCC>ACC	p.A472T	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	472										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CTTCCGCCCCGCCAAAAAGAT	0.483													A	119968731	A	A	119968731	3	1	143	1	0	0	0	0	1	0	0	0	2831	1087	38	1	1464	1	CCDC60	12	119968731	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	46953288	119968731	13883164	54	9804											
TDRD3	81550	broad.mit.edu	37	chr13	61103056	61103056	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagtggtataaaaattgaaaAacattttaatgtaaatactg	6	3	0	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr13:61103056A>G	uc001via.2	+	11	2206	c.1418A>G	c.(1417-1419)AAA>AGA	p.K473R	TDRD3_uc010aef.2_Missense_Mutation_p.K298R|TDRD3_uc001vhz.3_Missense_Mutation_p.K473R|TDRD3_uc010aeg.2_Missense_Mutation_p.K566R|TDRD3_uc001vib.3_Missense_Mutation_p.K472R	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	473					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		AAAATTGAAAAACATTTTAAT	0.313													G	61103056	G	G	61103056	3	3	143	1	0	0	0	0	1	0	0	0	15729	14	1	4	1739	4	TDRD3	13	61103056	Missense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08		61103056	54066822	55	9805											
COL4A2	1284	broad.mit.edu	37	chr13	111077144	111077144	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggattacaaggattcccgGgactgcagggacgtaaagga	14	8	0	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr13:111077144G>A	uc001vqx.2	+	5	533	c.244G>A	c.(244-246)GGA>AGA	p.G82R		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	82					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGGATTCCCGGGACTGCAGGG	0.597													A	111077144	A	A	111077144	3	1	143	1	0	0	0	0	1	0	0	0	3690	1233	43	3	258	3	COL4A2	13	111077144	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	49974088	111077144	4092734	56	9806											
RNASE10	338879	broad.mit.edu	37	chr14	20979116	20979116	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcattgcctgtgagctcaaGgggggaaaatgtcacaaaag	13	7	3	1	rs148975319		TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr14:20979116G>A	uc010tlj.1	+	1	486	c.486G>A	c.(484-486)AAG>AAA	p.K162K	RNASE10_uc001vxp.2_Silent_p.K190K	NM_001012975	NP_001012993	Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	162						extracellular region	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		GTGAGCTCAAGGGGGGAAAAT	0.478													A	20979116	A	A	20979116	2	1	143	1	0	0	0	0	0	0	0	1	13400	991	35	3		3	RNASE10	14	20979116	Silent	SNP	G	TCGA-14-2554-01A-01D-1494-08		20979116	86370424	57	9807											
CKMT1B	1159	broad.mit.edu	37	chr15	43890515	43890515	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtgcacatcaaactgccccTgctaagcaaagtaaaggagt	9	10	1	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr15:43890515T>G	uc001zsc.2	+	8	1393	c.1001T>G	c.(1000-1002)CTG>CGG	p.L334R	CKMT1B_uc010uds.1_Missense_Mutation_p.L365R|CKMT1B_uc010udv.1_3'UTR|CKMT1B_uc001zsd.3_Missense_Mutation_p.L334R|CKMT1B_uc010bdj.2_RNA|CKMT1B_uc010udy.1_RNA	NM_020990	NP_066270	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B precursor	334	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	AAACTGCCCCTGCTAAGCAAA	0.537													G	43890515	G	G	43890515	3	3	143	1	0	0	0	0	1	0	0	0	3450	1580	55	5	1027	5	CKMT1B	15	43890515	Missense_Mutation	SNP	T	TCGA-14-2554-01A-01D-1494-08		43890515	58640877	58	9808											
CACNG3	10368	broad.mit.edu	37	chr16	24358110	24358110	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccctgaagatgctgactaCgaacaggacacagccgaata	9	11	0	3			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr16:24358110C>T	uc002dmf.2	+	2	1467	c.267C>T	c.(265-267)TAC>TAT	p.Y89Y		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	89					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		ATGCTGACTACGAACAGGACA	0.562													T	24358110	T	T	24358110	2	4	143	1	0	0	0	0	0	0	0	1	2558	547	19	1		1	CACNG3	16	24358110	Silent	SNP	C	TCGA-14-2554-01A-01D-1494-08		24358110	65996643	59	9809											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53671674	53671674	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaagctttgttctgcaagCtgaccttcagatagtaaaga	9	9	2	3			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr16:53671674C>T	uc002ehp.2	-	21	3217	c.3153G>A	c.(3151-3153)CAG>CAA	p.Q1051Q	RPGRIP1L_uc002eho.3_Silent_p.Q1017Q|RPGRIP1L_uc010vgy.1_Silent_p.Q1051Q|RPGRIP1L_uc010cbx.2_Silent_p.Q1017Q|RPGRIP1L_uc010vgz.1_Silent_p.Q1051Q	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	1051					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				GTTCTGCAAGCTGACCTTCAG	0.373													T	53671674	T	T	53671674	2	4	143	1	0	0	0	0	0	0	0	1	13550	796	28	3		3	RPGRIP1L	16	53671674	Silent	SNP	C	TCGA-14-2554-01A-01D-1494-08	29313564	53671674	36683079	60	9810											
MVD	4597	broad.mit.edu	37	chr16	88724388	88724388	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccggccattcagccaaatcCggtcctcggtgaagtccttg	10	15	1	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr16:88724388C>T	uc002flg.1	-	3	198	c.191G>A	c.(190-192)CGG>CAG	p.R64Q	MVD_uc002flf.1_5'Flank	NM_002461	NP_002452	P53602	MVD1_HUMAN	diphosphomevalonate decarboxylase	64					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CAGCCAAATCCGGTCCTCGGT	0.617													T	88724388	T	T	88724388	3	4	143	1	0	0	0	0	1	0	0	0	9994	652	23	2	1043	2	MVD	16	88724388	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	35052714	88724388	1630365	61	9811											
PER1	5187	broad.mit.edu	37	chr17	8053154	8053154	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtccatggagcaaggctcGccctcctccaggctccactg	10	16	0	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr17:8053154G>A	uc002gkd.2	-	5	808	c.570C>T	c.(568-570)GGC>GGT	p.G190G	PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Silent_p.G174G|PER1_uc010vus.1_Silent_p.G190G	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	190					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						AGCAAGGCTCGCCCTCCTCCA	0.602			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					A	8053154	A	A	8053154	2	1	143	1	0	0	0	0	0	0	0	1	11729	1074	38	1		1	PER1	17	8053154	Silent	SNP	G	TCGA-14-2554-01A-01D-1494-08		8053154	73142056	62	9812											
MADCAM1	8174	broad.mit.edu	37	chr19	498515	498515	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gccttcccggaccagctgacCgtctccccagcagccctggt	10	19	1	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr19:498515C>A	uc002los.2	+	3	367	c.357C>A	c.(355-357)ACC>ACA	p.T119T	MADCAM1_uc002lot.2_Silent_p.T119T|MADCAM1_uc010drq.2_Silent_p.T24T	NM_130760	NP_570116	Q13477	MADCA_HUMAN	mucosal vascular addressin cell adhesion	119	Extracellular (Potential).|Ig-like 2.				cell adhesion|immune response|regulation of immune response|signal transduction	integral to membrane|membrane fraction|plasma membrane					0		all_cancers(10;4.25e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCAGCTGACCGTCTCCCCAG	0.697													A	498515	A	A	498515	2	1	143	1	0	0	0	0	0	0	0	1	9151	639	23	5		5	MADCAM1	19	498515	Silent	SNP	C	TCGA-14-2554-01A-01D-1494-08		498515	58630468	63	9813											
HMHA1	23526	broad.mit.edu	37	chr19	1068628	1068628	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagccgccagcccgggcgaGctgcccaccgagggtgccgg	16	17	0	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr19:1068628G>A	uc002lqz.1	+	2	537	c.306G>A	c.(304-306)GAG>GAA	p.E102E	HMHA1_uc010xgd.1_Silent_p.E118E|HMHA1_uc010xge.1_Intron|HMHA1_uc002lra.1_5'UTR|HMHA1_uc002lrb.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	102					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCGGGCGAGCTGCCCACCG	0.716													A	1068628	A	A	1068628	2	1	143	1	0	0	0	0	0	0	0	1	7240	962	34	3		3	HMHA1	19	1068628	Silent	SNP	G	TCGA-14-2554-01A-01D-1494-08	570113	1068628	58060355	64	9814											
PIP5K1C	23396	broad.mit.edu	37	chr19	3653547	3653547	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actgcacgcagtacagcccaTagaacttgggcagcagcgtc	11	13	0	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr19:3653547T>C	uc002lyj.1	-	7	719	c.662A>G	c.(661-663)TAT>TGT	p.Y221C	PIP5K1C_uc010xhq.1_Missense_Mutation_p.Y221C|PIP5K1C_uc010xhr.1_Missense_Mutation_p.Y221C	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	221	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		GTACAGCCCATAGAACTTGGG	0.642													C	3653547	C	C	3653547	3	2	143	1	0	0	0	0	1	0	0	0	11941	1406	49	4	1392	4	PIP5K1C	19	3653547	Missense_Mutation	SNP	T	TCGA-14-2554-01A-01D-1494-08	2584919	3653547	55475436	65	9815											
CYP4F3	4051	broad.mit.edu	37	chr19	15760895	15760895	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatgccgtcatccaggagCggcgccgcaccctccctagc	11	18	1	1	rs141338088	byFrequency	TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr19:15760895C>T	uc002nbj.2	+	7	870	c.820C>T	c.(820-822)CGG>TGG	p.R274W	CYP4F3_uc010xok.1_Missense_Mutation_p.R274W|CYP4F3_uc010xol.1_Missense_Mutation_p.R274W|CYP4F3_uc010xom.1_Missense_Mutation_p.R125W|CYP4F3_uc002nbk.2_Missense_Mutation_p.R274W|CYP4F3_uc010xon.1_5'UTR	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	274					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						CATCCAGGAGCGGCGCCGCAC	0.567													T	15760895	T	T	15760895	3	4	143	1	0	0	0	0	1	0	0	0	4190	759	27	1	842	1	CYP4F3	19	15760895	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	12107348	15760895	43368088	66	9816											
ZNF208	7757	broad.mit.edu	37	chr19	22155163	22155163	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aaacctttgccacattcttcAcatttgtagggtttctctcc	5	12	3	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr19:22155163A>T	uc002nqp.2	-	5	2522	c.2373T>A	c.(2371-2373)TGT>TGA	p.C791*	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CACATTCTTCACATTTGTAGG	0.378													T	22155163	T	T	22155163	4	4	143	1	0	0	0	0	0	1	0	0	17763	157	6	5	1173	5	ZNF208	19	22155163	Nonsense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08	6394268	22155163	36973820	67	9817											
EML2	24139	broad.mit.edu	37	chr19	46127976	46127976	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacagatggggtgacactgaCctttgccccaaacatagagg	11	10	0	4			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr19:46127976C>T	uc002pcn.2	-	9	876	c.841_splice	c.e9+1	p.G281_splice	EML2_uc002pco.2_Splice_Site|EML2_uc002pcp.2_Splice_Site_p.G165_splice|EML2_uc010xxl.1_Splice_Site_p.G428_splice|EML2_uc010xxm.1_Splice_Site_p.G482_splice|EML2_uc010xxn.1_Splice_Site|EML2_uc010xxo.1_Splice_Site_p.G281_splice|EML2_uc010ekj.2_Intron|EML2_uc010ekk.1_Splice_Site	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like						sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		GTGACACTGACCTTTGCCCCA	0.507													T	46127976	T	T	46127976	5	4	143	1	0	0	0	0	0	0	1	0	5097	521	18	3	1151	3	EML2	19	46127976	Splice_Site	SNP	C	TCGA-14-2554-01A-01D-1494-08	23972813	46127976	13001007	68	9818											
SIGLEC9	27180	broad.mit.edu	37	chr19	51633283	51633283	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggtgaagccttgggactcgCggggacaggaggccactgac	17	10	0	2	rs141580830		TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr19:51633283C>A	uc002pvu.2	+	7	1406	c.1339C>A	c.(1339-1341)CGG>AGG	p.R447R	SIGLEC9_uc010yct.1_Intron	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	447	Cytoplasmic (Potential).				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		TTGGGACTCGCGGGGACAGGA	0.602													A	51633283	A	A	51633283	2	1	143	1	0	0	0	0	0	0	0	1	14315	759	27	5		5	SIGLEC9	19	51633283	Silent	SNP	C	TCGA-14-2554-01A-01D-1494-08	5505307	51633283	7495700	69	9819											
BIRC8	112401	broad.mit.edu	37	chr19	53792992	53792993	+	Frame_Shift_Ins	INS	-	G	G													tgtcaactgcttcagcacatINStgtttacaagtgaccagatg							TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr19:53792992_53792993insG	uc002qbk.2	-	1	1883_1884	c.635_636insC	c.(634-636)CAAfs	p.Q212fs		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	212	RING-type.				apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		CTTCAGCACATTGTTTACAAGT	0.426													G	53792993	G	G	53792992	7	5	143	1	0	1	1	0	0	0	0	0	1440	1490	52	0	78	0	BIRC8	19	53792992	Frame_Shift_Ins	INS	-	TCGA-14-2554-01A-01D-1494-08	2159709	53792992	5335991	70	9820											
NLRP11	204801	broad.mit.edu	37	chr19	56300621	56300621	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttcaccaacatgcagttgggAtgtctcaaaccaccacatag	7	12	2	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr19:56300621A>T	uc010ygf.1	-	10	3369	c.2658T>A	c.(2656-2658)CAT>CAA	p.H886Q	NLRP11_uc002qlz.2_Missense_Mutation_p.H733Q|NLRP11_uc002qmb.2_Missense_Mutation_p.H787Q|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	886							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TGCAGTTGGGATGTCTCAAAC	0.453													T	56300621	T	T	56300621	3	4	143	1	0	0	0	0	1	0	0	0	10473	330	12	5	455	5	NLRP11	19	56300621	Missense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08	2507629	56300621	2828362	71	9821											
APCDD1L	164284	broad.mit.edu	37	chr20	57035877	57035877	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggaggaaggccagccctagaActaggggcagaagtgggaag	18	7	0	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr20:57035877A>T	uc002xze.1	-	4	1661	c.1475T>A	c.(1474-1476)GTT>GAT	p.V492D	APCDD1L_uc010zzp.1_Missense_Mutation_p.V503D	NM_153360	NP_699191	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated	492	Helical; (Potential).					integral to membrane				ovary(1)	1	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			CAGCCCTAGAACTAGGGGCAG	0.612													T	57035877	T	T	57035877	3	4	143	1	0	0	0	0	1	0	0	0	766	43	2	5	34	5	APCDD1L	20	57035877	Missense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08		57035877	5989643	72	9822											
LARGE	9215	broad.mit.edu	37	chr22	34046457	34046457	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agtgccctcctccatggagtAggtcttggagtggttgcctc	13	11	1	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chr22:34046457A>T	uc003and.3	-	4	883	c.304T>A	c.(304-306)TAC>AAC	p.Y102N	LARGE_uc003ane.3_Missense_Mutation_p.Y102N|LARGE_uc010gwp.2_Missense_Mutation_p.Y102N|LARGE_uc011ame.1_Missense_Mutation_p.Y34N|LARGE_uc011amf.1_Missense_Mutation_p.Y102N	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	102	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				TCCATGGAGTAGGTCTTGGAG	0.667													T	34046457	T	T	34046457	3	4	143	1	0	0	0	0	1	0	0	0	8627	420	15	5	2018	5	LARGE	22	34046457	Missense_Mutation	SNP	A	TCGA-14-2554-01A-01D-1494-08		34046457	17258109	73	9823											
MXRA5	25878	broad.mit.edu	37	chrX	3238673	3238673	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcttcggtcagtaaacttacTaggaatgctgggtttggaca	11	7	2	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:3238673T>C	uc004crg.3	-	5	5210	c.5053A>G	c.(5053-5055)AGT>GGT	p.S1685G		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1685						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTAAACTTACTAGGAATGCTG	0.438													C	3238673	C	C	3238673	3	2	143	1	0	0	0	0	1	0	0	0	10003	1522	53	4	3445	4	MXRA5	23	3238673	Missense_Mutation	SNP	T	TCGA-14-2554-01A-01D-1494-08		3238673	152031887	74	9824											
MAGEB1	4112	broad.mit.edu	37	chrX	30269312	30269312	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggagcctatgatggagaggaGcacttaatctatggggaacc	14	7	1	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:30269312G>T	uc004dcc.2	+	4	1022	c.702G>T	c.(700-702)GAG>GAT	p.E234D	MAGEB1_uc004dcd.2_Missense_Mutation_p.E234D|MAGEB1_uc004dce.2_Missense_Mutation_p.E234D	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	234	MAGE.										0						ATGGAGAGGAGCACTTAATCT	0.498													T	30269312	T	T	30269312	3	4	143	1	0	0	0	0	1	0	0	0	9172	962	34	5	704	5	MAGEB1	23	30269312	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	27030639	30269312	125001248	75	9825											
FAM47A	158724	broad.mit.edu	37	chrX	34150178	34150178	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggggagtaaaaactcgtcaCggcgacaaacgagagtatct	12	8	2	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:34150178C>T	uc004ddg.2	-	1	251	c.218G>A	c.(217-219)CGT>CAT	p.R73H		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	73										ovary(4)|central_nervous_system(1)	5						AAACTCGTCACGGCGACAAAC	0.532													T	34150178	T	T	34150178	3	4	143	1	0	0	0	0	1	0	0	0	5569	536	19	1	2161	1	FAM47A	23	34150178	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	3880866	34150178	121120382	76	9826											
ZNF674	641339	broad.mit.edu	37	chrX	46387797	46387797	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcctcacctgcacaggtccGtaccggggtccctccatctg	10	17	2	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:46387797G>A	uc004dgr.2	-	5	453	c.226C>T	c.(226-228)CGG>TGG	p.R76W	ZNF674_uc011mlg.1_Missense_Mutation_p.R76W|ZNF674_uc010nhm.2_Missense_Mutation_p.R76W	NM_001039891	NP_001034980	Q2M3X9	ZN674_HUMAN	zinc finger family member 674 isoform 1	76	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)	2						GCACAGGTCCGTACCGGGGTC	0.587													A	46387797	A	A	46387797	3	1	143	1	0	0	0	0	1	0	0	0	18078	1144	40	1	1527	1	ZNF674	23	46387797	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	12237619	46387797	108882763	77	9827											
ARHGEF9	23229	broad.mit.edu	37	chrX	62926262	62926262	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacagaggcagtctgaattgGggtccaggtgtccgttctgc	15	9	2	2			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:62926262G>T	uc004dvl.2	-	3	1096	c.257C>A	c.(256-258)CCC>CAC	p.P86H	ARHGEF9_uc004dvj.1_5'UTR|ARHGEF9_uc004dvk.1_5'UTR|ARHGEF9_uc011mos.1_Missense_Mutation_p.P65H|ARHGEF9_uc004dvm.1_Missense_Mutation_p.P65H|ARHGEF9_uc011mot.1_Missense_Mutation_p.P33H|ARHGEF9_uc004dvn.2_Missense_Mutation_p.P93H	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	86					apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						GTCTGAATTGGGGTCCAGGTG	0.547													T	62926262	T	T	62926262	3	4	143	1	0	0	0	0	1	0	0	0	912	1232	43	5	1325	5	ARHGEF9	23	62926262	Missense_Mutation	SNP	G	TCGA-14-2554-01A-01D-1494-08	16538465	62926262	92344298	78	9828											
THOC2	57187	broad.mit.edu	37	chrX	122799518	122799518	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcataaatgacttgcctatgCgcaccacttttgcaaataaa	5	10	1	1			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:122799518C>T	uc004etu.2	-	12	1393	c.1361G>A	c.(1360-1362)CGC>CAC	p.R454H	THOC2_uc011muh.1_Missense_Mutation_p.R375H|THOC2_uc011mui.1_Missense_Mutation_p.R339H	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	454					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						CTTGCCTATGCGCACCACTTT	0.358													T	122799518	T	T	122799518	3	4	143	1	0	0	0	0	1	0	0	0	15862	768	27	1	3528	1	THOC2	23	122799518	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	59873256	122799518	32471042	79	9829											
STAG2	10735	broad.mit.edu	37	chrX	123215351	123215351	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggacttgatcagttgaaaaCaagagaagccattgccatgc	10	8	1	3			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:123215351C>A	uc004etz.3	+	27	3236	c.2897C>A	c.(2896-2898)ACA>AAA	p.T966K	STAG2_uc004eua.2_Missense_Mutation_p.T966K|STAG2_uc004eub.2_Missense_Mutation_p.T966K|STAG2_uc004euc.2_Missense_Mutation_p.T966K|STAG2_uc004eud.2_Missense_Mutation_p.T966K|STAG2_uc004eue.2_Missense_Mutation_p.T966K	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	966					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CAGTTGAAAACAAGAGAAGCC	0.328													A	123215351	A	A	123215351	3	1	143	1	0	0	0	0	1	0	0	0	15242	478	17	5	2999	5	STAG2	23	123215351	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	415833	123215351	32055209	80	9830											
ODZ1	10178	broad.mit.edu	37	chrX	123870959	123870959	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagtccgctgcagggggtggCttcctggcacaggtgcaggc	18	11	0	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:123870959C>A	uc004euj.2	-	4	688	c.624G>T	c.(622-624)AAG>AAT	p.K208N	ODZ1_uc011muj.1_Missense_Mutation_p.K208N|ODZ1_uc010nqy.2_Missense_Mutation_p.K208N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	208	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CAGGGGGTGGCTTCCTGGCAC	0.622													A	123870959	A	A	123870959	3	1	143	1	0	0	0	0	1	0	0	0	10834	796	28	5	7690	5	ODZ1	23	123870959	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	655608	123870959	31399601	81	9831											
FLNA	2316	broad.mit.edu	37	chrX	153581719	153581719	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctcctcccggcccgagggCgggaccacagtggccgtcag	16	16	1	0			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:153581719C>T	uc004fkk.2	-	37	6216	c.5967G>A	c.(5965-5967)CCG>CCA	p.P1989P	FLNA_uc004fki.2_Silent_p.P32P|FLNA_uc011mzn.1_Silent_p.P122P|FLNA_uc010nuu.1_Silent_p.P1981P	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1989	Filamin 18.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGCCCGAGGGCGGGACCACAG	0.627													T	153581719	T	T	153581719	2	4	143	1	0	0	0	0	0	0	0	1	5933	755	27	1		1	FLNA	23	153581719	Silent	SNP	C	TCGA-14-2554-01A-01D-1494-08	29710760	153581719	1688841	82	9832											
F8	2157	broad.mit.edu	37	chrX	154185266	154185266	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gatctacagattctttgtagCagatgaggagagggccaatg	13	6	2	4			TCGA-14-2554-01A-01D-1494-08	TCGA-14-2554-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	53dec97d-0464-4ffd-8e2e-95b2b9a03af0	ea96115e-f5c4-4f9b-a1dc-ec2c4f591b2b	g.chrX:154185266C>A	uc004fmt.2	-	11	1889	c.1718G>T	c.(1717-1719)TGC>TTC	p.C573F		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	573	F5/8 type A 2.|Plastocyanin-like 3.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCTTTGTAGCAGATGAGGAG	0.448													A	154185266	A	A	154185266	3	1	143	1	0	0	0	0	1	0	0	0	5350	710	25	5	5429	5	F8	23	154185266	Missense_Mutation	SNP	C	TCGA-14-2554-01A-01D-1494-08	603547	154185266	1085294	83	9833											
KCNQ4	9132	broad.mit.edu	37	chr1	41289931	41289931	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tccttctgccctggggaaagGtaggggccccgtggggctgc	17	12	1	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr1:41289931G>T	uc001cgh.1	+	9	1374	c.1292_splice	c.e9+1	p.S431_splice	KCNQ4_uc001cgi.1_Intron	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein						sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			CTGGGGAAAGGTAGGGGCCCC	0.667													T	41289931	T	T	41289931	5	4	144	1	0	0	0	0	0	0	1	0	8085	1275	44	5	1327	5	KCNQ4	1	41289931	Splice_Site	SNP	G	TCGA-14-3476-01B-01D-1353-08		41289931	207960690	1	9834											
ZNHIT6	54680	broad.mit.edu	37	chr1	86172017	86172017	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttacatgtcagttctgctttGtgtttctttacacagggcaa	8	8	3	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr1:86172017G>C	uc001dlh.2	-	3	878	c.744C>G	c.(742-744)CAC>CAG	p.H248Q	ZNHIT6_uc010osc.1_Missense_Mutation_p.H209Q	NM_017953	NP_060423	Q9NWK9	BCD1_HUMAN	zinc finger, HIT type 6	248	HIT-type.				box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			large_intestine(1)	1						GTTCTGCTTTGTGTTTCTTTA	0.353													C	86172017	C	C	86172017	3	2	144	1	0	0	0	0	1	0	0	0	18206	1368	48	5	700	5	ZNHIT6	1	86172017	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	44882086	86172017	163078604	2	9835											
GPR61	83873	broad.mit.edu	37	chr1	110086728	110086728	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtttgtctgcttcttcaagCcagctccagaggaggagctg	12	10	3	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr1:110086728C>A	uc001dxy.2	+	2	1767	c.1084C>A	c.(1084-1086)CCA>ACA	p.P362T		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	362	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTTCTTCAAGCCAGCTCCAGA	0.557													A	110086728	A	A	110086728	3	1	144	1	0	0	0	0	1	0	0	0	6702	739	26	5	1086	5	GPR61	1	110086728	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	23914711	110086728	139163893	3	9836											
S100A7A	338324	broad.mit.edu	37	chr1	153391619	153391619	+	Splice_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttgtatgtttttctcttcacAggacaaaaagggcatacatt	7	7	2	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr1:153391619A>T	uc001fbt.1	+	3	199	c.142_splice	c.e3-2	p.D48_splice		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1							cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTCTTCACAGGACAAAAAG	0.408													T	153391619	T	T	153391619	5	4	144	1	0	0	0	0	0	0	1	0	13784	202	7	5	146	5	S100A7A	1	153391619	Splice_Site	SNP	A	TCGA-14-3476-01B-01D-1353-08	43304891	153391619	95859002	4	9837											
OLFML2B	25903	broad.mit.edu	37	chr1	161967994	161967994	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccagggtgcggtccgagcGttcaggtcgcttgtcacagc	15	12	2	0	rs34123330	byFrequency	TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr1:161967994G>A	uc001gbu.2	-	6	1519	c.1095C>T	c.(1093-1095)AAC>AAT	p.N365N	OLFML2B_uc010pkq.1_Silent_p.N366N	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	365										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			CGGTCCGAGCGTTCAGGTCGC	0.612													A	161967994	A	A	161967994	2	1	144	1	0	0	0	0	0	0	0	1	10858	1136	40	1		1	OLFML2B	1	161967994	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08	8576375	161967994	87282627	5	9838											
CEP350	9857	broad.mit.edu	37	chr1	180053197	180053197	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttgaaggtaggatcagagctCtgaaggatgagttgcggaaa	15	4	2	4			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr1:180053197C>G	uc001gnt.2	+	31	6552	c.6169C>G	c.(6169-6171)CTG>GTG	p.L2057V	CEP350_uc009wxl.2_Missense_Mutation_p.L2056V|CEP350_uc001gnv.2_Missense_Mutation_p.L192V|CEP350_uc001gnw.1_5'Flank	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2057	Potential.					centrosome|nucleus|spindle				ovary(4)	4						GATCAGAGCTCTGAAGGATGA	0.358													G	180053197	G	G	180053197	3	3	144	1	0	0	0	0	1	0	0	0	3254	912	32	5	6287	5	CEP350	1	180053197	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	18085203	180053197	69197424	6	9839											
DSTYK	25778	broad.mit.edu	37	chr1	205138447	205138447	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttcgagtatattccagacGtttgggagtgatctgcaggt	12	6	1	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr1:205138447G>A	uc001hbw.2	-	3	1232	c.1168C>T	c.(1168-1170)CGT>TGT	p.R390C	DSTYK_uc001hbx.2_Missense_Mutation_p.R390C|DSTYK_uc001hby.1_Intron	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	390						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						TATTCCAGACGTTTGGGAGTG	0.458													A	205138447	A	A	205138447	3	1	144	1	0	0	0	0	1	0	0	0	4785	1145	40	1	1665	1	DSTYK	1	205138447	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	25085250	205138447	44112174	7	9840											
USH2A	7399	broad.mit.edu	37	chr1	216138718	216138718	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgttaagagtccattagggCgaaaaggtgcttcccacctc	11	10	0	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr1:216138718C>T	uc001hku.1	-	37	7448	c.7061G>A	c.(7060-7062)CGC>CAC	p.R2354H		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2354	Extracellular (Potential).|Fibronectin type-III 10.		R -> H (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCCATTAGGGCGAAAAGGTGC	0.403										HNSCC(13;0.011)			T	216138718	T	T	216138718	3	4	144	1	0	0	0	0	1	0	0	0	17033	768	27	1	8691	1	USH2A	1	216138718	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	11000271	216138718	33111903	8	9841											
ASAP2	8853	broad.mit.edu	37	chr2	9347326	9347326	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcttcaccacccgcacggcGcagtgccggaacactgtggc	12	16	1	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:9347326G>A	uc002qzh.2	+	1	433	c.93G>A	c.(91-93)GCG>GCA	p.A31A	ASAP2_uc002qzi.2_Silent_p.A31A	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	31					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						CCCGCACGGCGCAGTGCCGGA	0.731													A	9347326	A	A	9347326	2	1	144	1	0	0	0	0	0	0	0	1	1011	1074	38	1		1	ASAP2	2	9347326	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08		9347326	233852047	9	9842											
EHD3	30845	broad.mit.edu	37	chr2	31484555	31484555	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caccagatctcacctggggaCttccccaatctgaagaggat	9	13	2	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:31484555C>A	uc002rnu.2	+	5	1664	c.1056C>A	c.(1054-1056)GAC>GAA	p.D352E	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	352					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					CACCTGGGGACTTCCCCAATC	0.592													A	31484555	A	A	31484555	3	1	144	1	0	0	0	0	1	0	0	0	4979	564	20	5	1074	5	EHD3	2	31484555	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	22137229	31484555	211714818	10	9843											
BCL11A	53335	broad.mit.edu	37	chr2	60689292	60689292	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agcgcccttctgccaggccgGaagcctctctcgatactgat	10	15	2	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:60689292G>A	uc002sae.1	-	4	983	c.755C>T	c.(754-756)TCC>TTC	p.S252F	BCL11A_uc002sab.2_Missense_Mutation_p.S252F|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Missense_Mutation_p.S218F|BCL11A_uc002sad.1_Missense_Mutation_p.S100F|BCL11A_uc002saf.1_Missense_Mutation_p.S218F	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	252					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGCCAGGCCGGAAGCCTCTCT	0.567			T	IGH@	B-CLL								A	60689292	A	A	60689292	3	1	144	1	0	0	0	0	1	0	0	0	1363	1174	41	3	1862	3	BCL11A	2	60689292	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	29204737	60689292	182510081	11	9844											
CKAP2L	150468	broad.mit.edu	37	chr2	113514622	113514622	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gcttagagtatgggttagaaGaaacacattctgaagtcagc	11	6	2	4			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:113514622G>A	uc002tie.2	-	4	405	c.326C>T	c.(325-327)TCT>TTT	p.S109F	CKAP2L_uc002tif.2_5'UTR|CKAP2L_uc010yxp.1_5'UTR|CKAP2L_uc010yxq.1_5'UTR	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	109						centrosome					0						TGGGTTAGAAGAAACACATTC	0.473													A	113514622	A	A	113514622	3	1	144	1	0	0	0	0	1	0	0	0	3443	942	33	3	1935	3	CKAP2L	2	113514622	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	52825330	113514622	129684751	12	9845											
MARCO	8685	broad.mit.edu	37	chr2	119726837	119726837	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgggctgctggtggtccaaGgtaaagcaggcttggtcctg	16	9	0	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:119726837G>T	uc002tln.1	+	2	331	c.199G>T	c.(199-201)GTT>TTT	p.V67F	MARCO_uc010yyf.1_5'UTR	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	67	Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGTGGTCCAAGGTAAAGCAGG	0.612													T	119726837	T	T	119726837	3	4	144	1	0	0	0	0	1	0	0	0	9311	1014	35	5	205	5	MARCO	2	119726837	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	6212215	119726837	123472536	13	9846											
LRP1B	53353	broad.mit.edu	37	chr2	141143511	141143511	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagtcattttggctatcacaCcgccagtgatcgggaataca	9	11	2	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:141143511C>A	uc002tvj.1	-	67	11454	c.10482G>T	c.(10480-10482)CGG>CGT	p.R3494R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3494	Extracellular (Potential).|LDL-receptor class A 25.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGCTATCACACCGCCAGTGAT	0.378										TSP Lung(27;0.18)			A	141143511	A	A	141143511	2	1	144	1	0	0	0	0	0	0	0	1	8955	494	18	5		5	LRP1B	2	141143511	Silent	SNP	C	TCGA-14-3476-01B-01D-1353-08	21416674	141143511	102055862	14	9847											
CSRNP3	80034	broad.mit.edu	37	chr2	166535947	166535947	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagcaattcgttgactatgCccgacaagcagaagaggcct	12	10	0	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:166535947C>T	uc002udf.2	+	7	1818	c.1442C>T	c.(1441-1443)GCC>GTC	p.A481V	CSRNP3_uc002udg.2_Missense_Mutation_p.A481V	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	481					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						GTTGACTATGCCCGACAAGCA	0.512													T	166535947	T	T	166535947	3	4	144	1	0	0	0	0	1	0	0	0	3965	739	26	3	1456	3	CSRNP3	2	166535947	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	25392436	166535947	76663426	15	9848											
SP5	389058	broad.mit.edu	37	chr2	171573817	171573817	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcggcaagcgcttcatgcGcagcgaccacctcgcgaagc	13	15	1	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:171573817G>A	uc002uge.2	+	2	1266	c.1100G>A	c.(1099-1101)CGC>CAC	p.R367H		NM_001003845	NP_001003845	Q6BEB4	SP5_HUMAN	Sp5 transcription factor	367	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGCTTCATGCGCAGCGACCAC	0.647													A	171573817	A	A	171573817	3	1	144	1	0	0	0	0	1	0	0	0	14967	1087	38	1	1106	1	SP5	2	171573817	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	5037870	171573817	71625556	16	9849											
TTN	7273	broad.mit.edu	37	chr2	179613920	179613920	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attttccttttctgatctacCaagttttccaaaattatttc	2	9	2	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:179613920C>A	uc002unb.2	-	46	13431	c.13207G>T	c.(13207-13209)GGT>TGT	p.G4403C	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGATCTACCAAGTTTTCCA	0.328													A	179613920	A	A	179613920	3	1	144	1	0	0	0	0	1	0	0	0	16732	594	21	5	97090	5	TTN	2	179613920	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	8040103	179613920	63585453	17	9850											
SGOL2	151246	broad.mit.edu	37	chr2	201437781	201437781	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaaatgaatcaaaaataaaTaagctcaggaataaagtgaa	6	4	2	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:201437781T>G	uc002uvw.2	+	7	2825	c.2712T>G	c.(2710-2712)AAT>AAG	p.N904K	SGOL2_uc010zhd.1_Missense_Mutation_p.N904K|SGOL2_uc010zhe.1_Missense_Mutation_p.N904K	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	904					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						CAAAAATAAATAAGCTCAGGA	0.299													G	201437781	G	G	201437781	3	3	144	1	0	0	0	0	1	0	0	0	14217	1403	49	5	2734	5	SGOL2	2	201437781	Missense_Mutation	SNP	T	TCGA-14-3476-01B-01D-1353-08	21823861	201437781	41761592	18	9851											
CPS1	1373	broad.mit.edu	37	chr2	211515146	211515146	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaaaattcctagaagaggCgactagagtttctcaggtag	11	6	1	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:211515146C>T	uc002vee.3	+	28	3596	c.3464C>T	c.(3463-3465)GCG>GTG	p.A1155V	CPS1_uc010fur.2_Missense_Mutation_p.A1161V|CPS1_uc010fus.2_Missense_Mutation_p.A704V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1155	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CTAGAAGAGGCGACTAGAGTT	0.368													T	211515146	T	T	211515146	3	4	144	1	0	0	0	0	1	0	0	0	3823	768	27	1	3596	1	CPS1	2	211515146	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	10077365	211515146	31684227	19	9852											
UGT1A9	54600	broad.mit.edu	37	chr2	234581022	234581022	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttttgatgcagtgtttctcGatccttttgataactgtggc	9	8	1	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr2:234581022G>A	uc002vus.2	+	1	479	c.442G>A	c.(442-444)GAT>AAT	p.D148N	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Missense_Mutation_p.D148N	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	148					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	AGTGTTTCTCGATCCTTTTGA	0.373													A	234581022	A	A	234581022	3	1	144	1	0	0	0	0	1	0	0	0	16949	1058	37	2	444	2	UGT1A9	2	234581022	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	23065876	234581022	8618351	20	9853											
ITPR1	3708	broad.mit.edu	37	chr3	4699832	4699832	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	accctgatcaggacgcctctCgaagtaggttgcggaatgcc	12	12	2	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:4699832C>T	uc003bqa.2	+	13	1369	c.1021C>T	c.(1021-1023)CGA>TGA	p.R341*	ITPR1_uc010hca.1_Nonsense_Mutation_p.R326*|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Nonsense_Mutation_p.R326*	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	341	Cytoplasmic (Potential).|MIR 4.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GGACGCCTCTCGAAGTAGGTT	0.488													T	4699832	T	T	4699832	4	4	144	1	0	0	0	0	0	1	0	0	7920	876	31	2	1063	2	ITPR1	3	4699832	Nonsense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08		4699832	193322598	21	9854											
SLC6A6	6533	broad.mit.edu	37	chr3	14513770	14513770	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gacaatgatgccgctgcccaCattttggtccattctttttt	7	11	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:14513770C>G	uc010heg.2	+	17	1445	c.1154C>G	c.(1153-1155)ACA>AGA	p.T385R	SLC6A6_uc003byq.2_Missense_Mutation_p.T385R|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	385	Helical; Name=8; (Potential).				cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						CCGCTGCCCACATTTTGGTCC	0.537													G	14513770	G	G	14513770	3	3	144	1	0	0	0	0	1	0	0	0	14688	478	17	5	1188	5	SLC6A6	3	14513770	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	9813938	14513770	183508660	22	9855											
C3orf20	84077	broad.mit.edu	37	chr3	14799033	14799033	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgacgtggagctggagcGcttcctgttggcgccccgag	15	13	1	1	rs151210868		TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:14799033G>A	uc003byy.2	+	13	2500	c.2096G>A	c.(2095-2097)CGC>CAC	p.R699H	C3orf20_uc003byz.2_Missense_Mutation_p.R577H|C3orf20_uc003bza.2_Missense_Mutation_p.R577H|C3orf20_uc003bzb.1_Missense_Mutation_p.R200H|C3orf20_uc011avj.1_Missense_Mutation_p.R26H	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	699						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						GAGCTGGAGCGCTTCCTGTTG	0.627													A	14799033	A	A	14799033	3	1	144	1	0	0	0	0	1	0	0	0	2213	1087	38	1	2138	1	C3orf20	3	14799033	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	285263	14799033	183223397	23	9856											
TTC21A	199223	broad.mit.edu	37	chr3	39156148	39156148	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	accagatcactgtgacttcaGggagcttcctgccagccctc	9	15	2	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:39156148G>C	uc003cjc.2	+	6	808	c.631G>C	c.(631-633)GGG>CGG	p.G211R	TTC21A_uc003cja.2_Missense_Mutation_p.G211R|TTC21A_uc010hho.1_Missense_Mutation_p.G133R|TTC21A_uc003cjb.2_Missense_Mutation_p.R77T|TTC21A_uc003cje.2_Missense_Mutation_p.G211R|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.G170R	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	211	TPR 4.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TGTGACTTCAGGGAGCTTCCT	0.552													C	39156148	C	C	39156148	3	2	144	1	0	0	0	0	1	0	0	0	16684	1000	35	5	653	5	TTC21A	3	39156148	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	24357115	39156148	158866282	24	9857											
CACNA2D2	9254	broad.mit.edu	37	chr3	50416395	50416395	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgtgacgtcatagttatgCtgccccacggagaaagtaaa	12	8	1	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:50416395C>T	uc003daq.2	-	13	1328	c.1290G>A	c.(1288-1290)CAG>CAA	p.Q430Q	CACNA2D2_uc003dap.2_Silent_p.Q430Q	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	430	VWFA.|Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	CATAGTTATGCTGCCCCACGG	0.587													T	50416395	T	T	50416395	2	4	144	1	0	0	0	0	0	0	0	1	2549	796	28	3		3	CACNA2D2	3	50416395	Silent	SNP	C	TCGA-14-3476-01B-01D-1353-08	11260247	50416395	147606035	25	9858											
ACOX2	8309	broad.mit.edu	37	chr3	58520774	58520774	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctctcgctctctatgtcGgggtgcatttgcctgctcca	9	14	2	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:58520774G>A	uc003dkl.2	-	2	235	c.60C>T	c.(58-60)CCC>CCT	p.P20P		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	20					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TCTCTATGTCGGGGTGCATTT	0.552													A	58520774	A	A	58520774	2	1	144	1	0	0	0	0	0	0	0	1	159	1103	39	2		2	ACOX2	3	58520774	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08	8104379	58520774	139501656	26	9859											
KLF15	28999	broad.mit.edu	37	chr3	126071173	126071173	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggcacctcctgcactggcaCcacctggtggaggggaacag	15	13	0	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:126071173C>G	uc011bkk.1	-	2	775	c.593G>C	c.(592-594)GGT>GCT	p.G198A		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	198						nucleus	DNA binding|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(114;0.147)		TGCACTGGCACCACCTGGTGG	0.662													G	126071173	G	G	126071173	3	3	144	1	0	0	0	0	1	0	0	0	8343	507	18	5	665	5	KLF15	3	126071173	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	67550399	126071173	71951257	27	9860											
COL6A6	131873	broad.mit.edu	37	chr3	130325803	130325803	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcagaaggggacatacagGcccacaggtacaatgatttt	12	8	0	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:130325803G>A	uc010htl.2	+	20	4713	c.4682G>A	c.(4681-4683)GGC>GAC	p.G1561D	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1561	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGACATACAGGCCCACAGGTA	0.353													A	130325803	A	A	130325803	3	1	144	1	0	0	0	0	1	0	0	0	3703	1203	42	3	4760	3	COL6A6	3	130325803	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	4254630	130325803	67696627	28	9861											
CPB1	1360	broad.mit.edu	37	chr3	148562321	148562321	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagcttctcgacaagttagaCttttatgtcctgcctgtgct	9	10	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:148562321C>A	uc003ewl.2	+	7	656	c.633C>A	c.(631-633)GAC>GAA	p.D211E		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	211					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			ACAAGTTAGACTTTTATGTCC	0.413													A	148562321	A	A	148562321	3	1	144	1	0	0	0	0	1	0	0	0	3796	564	20	5	659	5	CPB1	3	148562321	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	18236518	148562321	49460109	29	9862											
SLC7A14	57709	broad.mit.edu	37	chr3	170198876	170198876	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctcaagctgaccaacagtgCgaggagcgctgccaggaacc	12	13	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr3:170198876C>A	uc003fgz.2	-	7	1511	c.1195G>T	c.(1195-1197)GCA>TCA	p.A399S	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	399	Helical; (Potential).					integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			ACCAACAGTGCGAGGAGCGCT	0.592													A	170198876	A	A	170198876	3	1	144	1	0	0	0	0	1	0	0	0	14696	768	27	5	1128	5	SLC7A14	3	170198876	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	21636555	170198876	27823554	30	9863											
BOD1L	259282	broad.mit.edu	37	chr4	13583896	13583896	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtgtcatcatcgttctgctCtggcttttcaccagtagttt	9	10	5	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr4:13583896C>T	uc003gmz.1	-	19	8674	c.8557G>A	c.(8557-8559)GAG>AAG	p.E2853K		NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2853							DNA binding			ovary(5)|breast(1)	6						TCGTTCTGCTCTGGCTTTTCA	0.383													T	13583896	T	T	13583896	3	4	144	1	0	0	0	0	1	0	0	0	1483	922	32	3	630	3	BOD1L	4	13583896	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08		13583896	177570380	31	9864											
EGF	1950	broad.mit.edu	37	chr4	110915953	110915953	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccgtaagaaatagtgactcTgaatgtcccctgtcccacga	8	12	1	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr4:110915953T>C	uc003hzy.3	+	20	3374	c.2922T>C	c.(2920-2922)TCT>TCC	p.S974S	EGF_uc011cfu.1_Silent_p.S932S|EGF_uc011cfv.1_Silent_p.S933S|EGF_uc010imk.2_Silent_p.S122S	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	974	EGF-like 9.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ATAGTGACTCTGAATGTCCCC	0.438													C	110915953	C	C	110915953	2	2	144	1	0	0	0	0	0	0	0	1	4962	1567	55	4		4	EGF	4	110915953	Silent	SNP	T	TCGA-14-3476-01B-01D-1353-08	97332057	110915953	80238323	32	9865											
PRDM9	56979	broad.mit.edu	37	chr5	23522495	23522495	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacaaagaggtcagcgagccGcaggatgatgattacctctg	12	9	2	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr5:23522495G>A	uc003jgo.2	+	7	773	c.591G>A	c.(589-591)CCG>CCA	p.P197P		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	197					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TCAGCGAGCCGCAGGATGATG	0.443										HNSCC(3;0.000094)			A	23522495	A	A	23522495	2	1	144	1	0	0	0	0	0	0	0	1	12463	1074	38	1		1	PRDM9	5	23522495	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08		23522495	157392765	33	9866											
NDUFAF2	91942	broad.mit.edu	37	chr5	60368982	60368982	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcgagagaaaagaattgtagAagcagcaaataaaaaagaag	10	3	0	4			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr5:60368982A>G	uc003jsp.3	+	2	285	c.158A>G	c.(157-159)GAA>GGA	p.E53G	NDUFAF2_uc003jso.3_Intron	NM_174889	NP_777549	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	53						membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity				0		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				AGAATTGTAGAAGCAGCAAAT	0.323													G	60368982	G	G	60368982	3	3	144	1	0	0	0	0	1	0	0	0	10275	246	9	4	164	4	NDUFAF2	5	60368982	Missense_Mutation	SNP	A	TCGA-14-3476-01B-01D-1353-08	36846487	60368982	120546278	34	9867											
PCDHA5	56143	broad.mit.edu	37	chr5	140202989	140202989	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cgcgacgcgggcgtgccgccTctgggcagcaacgtgacgct	16	15	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr5:140202989T>A	uc003lhl.2	+	1	1629	c.1629T>A	c.(1627-1629)CCT>CCA	p.P543P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.P543P|PCDHA5_uc003lhj.1_Silent_p.P543P	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	543	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTGCCGCCTCTGGGCAGCA	0.701													A	140202989	A	A	140202989	2	1	144	1	0	0	0	0	0	0	0	1	11527	1538	54	5		5	PCDHA5	5	140202989	Silent	SNP	T	TCGA-14-3476-01B-01D-1353-08	79834007	140202989	40712271	35	9868											
PCDHGA12	26025	broad.mit.edu	37	chr5	140810930	140810930	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgaaacgcgccctggacCgcgaagaaaaggctgctcac	12	13	1	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr5:140810930C>T	uc003lkt.1	+	1	773	c.604C>T	c.(604-606)CGC>TGC	p.R202C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.R202C	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	202	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCCTGGACCGCGAAGAAAA	0.627													T	140810930	T	T	140810930	3	4	144	1	0	0	0	0	1	0	0	0	11553	652	23	2	606	2	PCDHGA12	5	140810930	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	607941	140810930	40104330	36	9869											
HAVCR1	26762	broad.mit.edu	37	chr5	156476070	156476070	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttgtgtaagagtacaatgGtgagctggtgggttctctcc	14	6	1	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr5:156476070G>A	uc010jij.1	-	5	945	c.760C>T	c.(760-762)CCA>TCA	p.P254S	HAVCR1_uc011ddl.1_Missense_Mutation_p.P85S|HAVCR1_uc003lwi.2_Missense_Mutation_p.P254S	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	249	Extracellular (Potential).				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAGTACAATGGTGAGCTGGTG	0.438													A	156476070	A	A	156476070	3	1	144	1	0	0	0	0	1	0	0	0	6973	1261	44	3	354	3	HAVCR1	5	156476070	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	15665140	156476070	24439190	37	9870											
SLIT3	6586	broad.mit.edu	37	chr5	168100307	168100307	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcgtcaccagctccacactgTgaaactgcccatcattcact	6	16	3	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr5:168100307T>C	uc003mab.2	-	33	4136	c.3716A>G	c.(3715-3717)CAC>CGC	p.H1239R	SLIT3_uc010jjg.2_Missense_Mutation_p.H1246R	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1239	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCCACACTGTGAAACTGCCC	0.567													C	168100307	C	C	168100307	3	2	144	1	0	0	0	0	1	0	0	0	14741	1696	59	4	871	4	SLIT3	5	168100307	Missense_Mutation	SNP	T	TCGA-14-3476-01B-01D-1353-08	11624237	168100307	12814953	38	9871											
BTBD9	114781	broad.mit.edu	37	chr6	38256182	38256182	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aaggcatttcggctccgactGactccttcaatcacactggc	8	14	2	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr6:38256182G>T	uc003ooa.3	-	9	1896	c.1320C>A	c.(1318-1320)GTC>GTA	p.V440V	BTBD9_uc003ony.3_Silent_p.V372V|BTBD9_uc010jwv.2_Silent_p.V401V|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Silent_p.V440V	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	440					cell adhesion						0						GGCTCCGACTGACTCCTTCAA	0.463													T	38256182	T	T	38256182	2	4	144	1	0	0	0	0	0	0	0	1	1548	1277	45	5		5	BTBD9	6	38256182	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08		38256182	132858885	39	9872											
SLC29A1	2030	broad.mit.edu	37	chr6	44198124	44198124	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcagcctgtttggtctggcTggccttctgcctgccagcta	13	13	2	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr6:44198124T>C	uc003owu.1	+	6	824	c.495T>C	c.(493-495)GCT>GCC	p.A165A	SLC29A1_uc011dvp.1_3'UTR|SLC29A1_uc003owv.1_Silent_p.A165A|SLC29A1_uc003oww.1_Silent_p.A244A|SLC29A1_uc011dvq.1_3'UTR|SLC29A1_uc003owx.1_Silent_p.A165A|SLC29A1_uc003owy.1_Silent_p.A165A|SLC29A1_uc003owz.1_Silent_p.A165A	NM_004955	NP_004946	Q99808	S29A1_HUMAN	equilibrative nucleoside transporter 1	165	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			large_intestine(2)|skin(1)	3	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	TTGGTCTGGCTGGCCTTCTGC	0.627													C	44198124	C	C	44198124	2	2	144	1	0	0	0	0	0	0	0	1	14534	1567	55	4		4	SLC29A1	6	44198124	Silent	SNP	T	TCGA-14-3476-01B-01D-1353-08	5941942	44198124	126916943	40	9873											
IMPG1	3617	broad.mit.edu	37	chr6	76744406	76744406	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatgtcaaagaggcagaaggTctcctgctggcagatgctga	13	8	2	4			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr6:76744406T>C	uc003pik.1	-	3	530	c.400A>G	c.(400-402)ACC>GCC	p.T134A		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	134					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AGGCAGAAGGTCTCCTGCTGG	0.498													C	76744406	C	C	76744406	3	2	144	1	0	0	0	0	1	0	0	0	7728	1667	58	4	2053	4	IMPG1	6	76744406	Missense_Mutation	SNP	T	TCGA-14-3476-01B-01D-1353-08	32546282	76744406	94370661	41	9874											
IL22RA2	116379	broad.mit.edu	37	chr6	137482860	137482860	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaagaaactgatgaggaaGcctagaaagcaatgtttagg	13	4	0	4			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr6:137482860G>A	uc003qhl.2	-	2	328	c.27C>T	c.(25-27)GGC>GGT	p.G9G	IL22RA2_uc003qhm.2_Silent_p.G9G|IL22RA2_uc003qhn.2_Silent_p.G9G	NM_052962	NP_443194	Q969J5	I22R2_HUMAN	interleukin 22-binding protein isoform 1	9					regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	interleukin-22 receptor activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000313)|OV - Ovarian serous cystadenocarcinoma(155;0.00407)		TGATGAGGAAGCCTAGAAAGC	0.413													A	137482860	A	A	137482860	2	1	144	1	0	0	0	0	0	0	0	1	7674	958	34	3		3	IL22RA2	6	137482860	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08	60738454	137482860	33632207	42	9875											
EZR	7430	broad.mit.edu	37	chr6	159239121	159239121	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggcaacttactggtttcGgcattttcggtttctggtga	12	8	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr6:159239121G>A	uc003qrt.3	-	1	220	c.5C>T	c.(4-6)CCG>CTG	p.P2L	EZR_uc011efs.1_Missense_Mutation_p.P2L|EZR_uc003qru.3_Missense_Mutation_p.P2L	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	2	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TACTGGTTTCGGCATTTTCGG	0.577													A	159239121	A	A	159239121	3	1	144	1	0	0	0	0	1	0	0	0	5335	1116	39	2	1807	2	EZR	6	159239121	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	21756261	159239121	11875946	43	9876											
DNAH11	8701	broad.mit.edu	37	chr7	21657267	21657267	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactcaacaaggaagtccgcGtctgggatgcttacacgggc	12	12	2	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr7:21657267G>A	uc003svc.2	+	23	4172	c.4141G>A	c.(4141-4143)GTC>ATC	p.V1381I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1381	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGAAGTCCGCGTCTGGGATGC	0.483									Kartagener_syndrome				A	21657267	A	A	21657267	3	1	144	1	0	0	0	0	1	0	0	0	4599	1145	40	1	4231	1	DNAH11	7	21657267	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08		21657267	137481396	44	9877											
CALN1	83698	broad.mit.edu	37	chr7	71275406	71275406	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atgttctcaatgtccttcatCgttaggtggtctcggaaggc	11	9	3	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr7:71275406C>T	uc003twa.3	-	5	974	c.447G>A	c.(445-447)ACG>ACA	p.T149T	CALN1_uc003twb.3_Silent_p.T191T|CALN1_uc003twc.3_Silent_p.T149T	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	149	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TGTCCTTCATCGTTAGGTGGT	0.463													T	71275406	T	T	71275406	2	4	144	1	0	0	0	0	0	0	0	1	2591	871	31	2		2	CALN1	7	71275406	Silent	SNP	C	TCGA-14-3476-01B-01D-1353-08	49618139	71275406	87863257	45	9878											
PMPCB	9512	broad.mit.edu	37	chr7	102937947	102937947	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtggtgttgtcatccgcggCgcggcggcggctctggggtt	19	10	2	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr7:102937947C>A	uc003vbl.2	+	1	75	c.41C>A	c.(40-42)GCG>GAG	p.A14E	PMPCB_uc010liu.1_Missense_Mutation_p.A14E|PMPCB_uc003vbk.1_Missense_Mutation_p.A14E|PMPCB_uc003vbm.2_5'UTR|PMPCB_uc010liv.2_5'UTR|PMPCB_uc010liw.2_5'UTR|PMPCB_uc011kll.1_5'UTR|PMPCB_uc011klm.1_5'Flank	NM_004279	NP_004270	O75439	MPPB_HUMAN	mitochondrial processing peptidase beta subunit	14					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4						TCATCCGCGGCGCGGCGGCGG	0.652											OREG0018240	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	102937947	A	A	102937947	3	1	144	1	0	0	0	0	1	0	0	0	12141	768	27	5	43	5	PMPCB	7	102937947	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	31662541	102937947	56200716	46	9879											
WEE2	494551	broad.mit.edu	37	chr7	141429401	141429401	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggtgacactggggtctctGggacccacacaggatcaaga	13	10	2	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr7:141429401G>A	uc003vwn.2	+	11	2012	c.1606G>A	c.(1606-1608)GGG>AGG	p.G536R	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	536					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					TGGGGTCTCTGGGACCCACAC	0.522													A	141429401	A	A	141429401	3	1	144	1	0	0	0	0	1	0	0	0	17342	1348	47	3	1648	3	WEE2	7	141429401	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	38491454	141429401	17709262	47	9880											
GIMAP8	155038	broad.mit.edu	37	chr7	150171495	150171495	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaaattctttgagtacatgAtcatacttcttaccaggaaa	5	7	3	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr7:150171495A>G	uc003whj.2	+	4	1408	c.1078A>G	c.(1078-1080)ATC>GTC	p.I360V		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	360						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TGAGTACATGATCATACTTCT	0.403													G	150171495	G	G	150171495	3	3	144	1	0	0	0	0	1	0	0	0	6385	333	12	4	1088	4	GIMAP8	7	150171495	Missense_Mutation	SNP	A	TCGA-14-3476-01B-01D-1353-08	8742094	150171495	8967168	48	9881											
GIMAP1	170575	broad.mit.edu	37	chr7	150417944	150417944	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggccctgctgctggggggCgcgctcctgttctgggtgct	17	13	1	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr7:150417944C>T	uc003whq.2	+	3	939	c.852C>T	c.(850-852)GGC>GGT	p.G284G	GIMAP1_uc003whp.2_Silent_p.G292G	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	284	Helical; Anchor for type IV membrane protein; (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCTGGGGGGCGCGCTCCTGT	0.687													T	150417944	T	T	150417944	2	4	144	1	0	0	0	0	0	0	0	1	6379	755	27	1		1	GIMAP1	7	150417944	Silent	SNP	C	TCGA-14-3476-01B-01D-1353-08	246449	150417944	8720719	49	9882											
PTDSS1	9791	broad.mit.edu	37	chr8	97296348	97296348	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tatctgcaggtccgttcactCgacctcatccagccttatgg	8	14	3	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr8:97296348C>G	uc003yht.1	+	3	385	c.283C>G	c.(283-285)CGA>GGA	p.R95G	PTDSS1_uc003yhu.1_Intron	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	95					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TCCGTTCACTCGACCTCATCC	0.353													G	97296348	G	G	97296348	3	3	144	1	0	0	0	0	1	0	0	0	12736	876	31	5	293	5	PTDSS1	8	97296348	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08		97296348	49067674	50	9883											
HSD17B3	3293	broad.mit.edu	37	chr9	99064323	99064323	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagaatctcacgcacttcgCcaggcaggccaggcacacca	11	15	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr9:99064323C>T	uc004awa.1	-	1	112	c.64G>A	c.(64-66)GCG>ACG	p.A22T	HSD17B3_uc010msc.1_Missense_Mutation_p.A22T	NM_000197	NP_000188	P37058	DHB3_HUMAN	estradiol 17 beta-dehydrogenase 3	22					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity				0		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	ACGCACTTCGCCAGGCAGGCC	0.547													T	99064323	T	T	99064323	3	4	144	1	0	0	0	0	1	0	0	0	7385	739	26	3	912	3	HSD17B3	9	99064323	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08		99064323	42149108	51	9884											
UCK1	83549	broad.mit.edu	37	chr9	134400596	134400596	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctggatgtgctgcacgatcAggttgatggcaactgcgcca	13	11	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr9:134400596A>G	uc004cay.2	-	7	766	c.665T>C	c.(664-666)CTG>CCG	p.L222P	UCK1_uc010mzk.2_Missense_Mutation_p.L213P|UCK1_uc004cba.2_Silent_p.P190P|UCK1_uc004caz.2_RNA	NM_031432	NP_113620	Q9HA47	UCK1_HUMAN	uridine-cytidine kinase 1 isoform a	222					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;2.34e-05)|Epithelial(140;0.000219)		CTGCACGATCAGGTTGATGGC	0.597													G	134400596	G	G	134400596	3	3	144	1	0	0	0	0	1	0	0	0	16920	188	7	4	172	4	UCK1	9	134400596	Missense_Mutation	SNP	A	TCGA-14-3476-01B-01D-1353-08	35336273	134400596	6812835	52	9885											
SFTPD	6441	broad.mit.edu	37	chr10	81701253	81701253	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctggacttccctggggacCcatggctccagcagaccctg	11	16	0	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr10:81701253C>T	uc001kbh.2	-	6	611	c.568G>A	c.(568-570)GGT>AGT	p.G190S	MBL1P_uc001kbf.2_Intron	NM_003019	NP_003010	P35247	SFTPD_HUMAN	pulmonary surfactant-associated protein D	190	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			skin(1)	1	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			CCCTGGGGACCCATGGCTCCA	0.507													T	81701253	T	T	81701253	3	4	144	1	0	0	0	0	1	0	0	0	14193	623	22	3	571	3	SFTPD	10	81701253	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08		81701253	53833494	53	9886											
MUC5B	727897	broad.mit.edu	37	chr11	1270908	1270908	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgcatccactggatccacGgccaccccgtcctccacccc	6	22	0	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr11:1270908G>A	uc009ycr.1	+	51	14343	c.14217G>A	c.(14215-14217)ACG>ACA	p.T4739T	MUC5B_uc001ltb.2_Silent_p.T4269T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4266	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTGGATCCACGGCCACCCCGT	0.647													A	1270908	A	A	1270908	2	1	144	1	0	0	0	0	0	0	0	1	9979	1103	39	2		2	MUC5B	11	1270908	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08		1270908	133735608	54	9887											
OR52A1	23538	broad.mit.edu	37	chr11	5172692	5172692	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acatttttaccacatgaatgCgaatctgtgtggtctttgca	8	8	2	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr11:5172692C>T	uc010qyy.1	-	1	908	c.908G>A	c.(907-909)CGC>CAC	p.R303H		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	303	Cytoplasmic (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACATGAATGCGAATCTGTGT	0.358													T	5172692	T	T	5172692	3	4	144	1	0	0	0	0	1	0	0	0	11108	768	27	1	32	1	OR52A1	11	5172692	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	3901784	5172692	129833824	55	9888											
PDE3B	5140	broad.mit.edu	37	chr11	14825558	14825558	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cccgaagcaaaggtcatcttCtgtatcactgactcaccatg	7	13	5	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr11:14825558C>A	uc001mln.2	+	5	1837	c.1484C>A	c.(1483-1485)TCT>TAT	p.S495Y	PDE3B_uc010rcr.1_Missense_Mutation_p.S444Y	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	495					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						AGGTCATCTTCTGTATCACTG	0.358													A	14825558	A	A	14825558	3	1	144	1	0	0	0	0	1	0	0	0	11638	913	32	5	1502	5	PDE3B	11	14825558	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	9652866	14825558	120180958	56	9889											
OR4A47	403253	broad.mit.edu	37	chr11	48511019	48511019	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcttgcactctttaaagaaCcttagtcagaaagggaggca	9	8	3	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr11:48511019C>A	uc010rhx.1	+	1	675	c.675C>A	c.(673-675)AAC>AAA	p.N225K		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTTAAAGAACCTTAGTCAGA	0.438													A	48511019	A	A	48511019	3	1	144	1	0	0	0	0	1	0	0	0	11042	506	18	5	677	5	OR4A47	11	48511019	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	33685461	48511019	86495497	57	9890											
OR4A5	81318	broad.mit.edu	37	chr11	51412194	51412194	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggtagtggaatatgcagcatCtataaatgacaggcaggcaa	12	6	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr11:51412194C>A	uc001nhi.1	-	1	202	c.202G>T	c.(202-204)GAT>TAT	p.D68Y		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				TATGCAGCATCTATAAATGAC	0.438													A	51412194	A	A	51412194	3	1	144	1	0	0	0	0	1	0	0	0	11043	913	32	5	749	5	OR4A5	11	51412194	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	2901175	51412194	83594322	58	9891											
OR8I2	120586	broad.mit.edu	37	chr11	55861592	55861592	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacatcatcgctgacccaggCgcaggtggcatctgtattct	10	13	3	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr11:55861592C>T	uc010rix.1	+	1	809	c.809C>T	c.(808-810)GCG>GTG	p.A270V		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					CTGACCCAGGCGCAGGTGGCA	0.453													T	55861592	T	T	55861592	3	4	144	1	0	0	0	0	1	0	0	0	11240	768	27	1	811	1	OR8I2	11	55861592	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	4449398	55861592	79144924	59	9892											
FAT3	120114	broad.mit.edu	37	chr11	92532113	92532113	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttaaagaagccatggacagCggcctccactttacacaaag	9	11	0	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr11:92532113C>T	uc001pdj.3	+	9	5951	c.5934C>T	c.(5932-5934)AGC>AGT	p.S1978S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1978	Cadherin 17.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCATGGACAGCGGCCTCCACT	0.433										TCGA Ovarian(4;0.039)			T	92532113	T	T	92532113	2	4	144	1	0	0	0	0	0	0	0	1	5691	767	27	1		1	FAT3	11	92532113	Silent	SNP	C	TCGA-14-3476-01B-01D-1353-08	36670521	92532113	42474403	60	9893											
CLEC1A	51267	broad.mit.edu	37	chr12	10233990	10233990	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atggtgtcttgaccagtattGgagagctggtagtactgaaa	13	5	1	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr12:10233990G>T	uc001qxb.2	-	3	321	c.237C>A	c.(235-237)TCC>TCA	p.S79S	CLEC1A_uc009zhf.2_5'UTR|CLEC1A_uc001qxc.2_5'UTR|CLEC1A_uc001qxd.2_Silent_p.S36S|CLEC1A_uc010sgx.1_Intron	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1	79	Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2						GACCAGTATTGGAGAGCTGGT	0.378													T	10233990	T	T	10233990	2	4	144	1	0	0	0	0	0	0	0	1	3505	1335	47	5		5	CLEC1A	12	10233990	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08		10233990	123617905	61	9894											
PRB1	5542	broad.mit.edu	37	chr12	11506753	11506753	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ggggtggtccttgtggttttCctggaggagatcggggactt	18	6	0	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr12:11506753C>A	uc001qzw.1	-	3	321	c.284G>T	c.(283-285)GGA>GTA	p.G95V	PRB1_uc001qzu.1_Missense_Mutation_p.G95V|PRB1_uc001qzv.1_Missense_Mutation_p.G95V	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	156	6.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTGTGGTTTTCCTGGAGGAGA	0.607													A	11506753	A	A	11506753	3	1	144	1	0	0	0	0	1	0	0	0	12442	855	30	5	715	5	PRB1	12	11506753	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	1272763	11506753	122345142	62	9895											
ATP2B1	490	broad.mit.edu	37	chr12	90024361	90024361	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaggtaaagataattccagtTtgagaatttacacctacagc	7	7	0	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr12:90024361T>C	uc001tbh.2	-	5	1030	c.849A>G	c.(847-849)CAA>CAG	p.Q283Q	ATP2B1_uc001tbg.2_Silent_p.Q283Q	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	283	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TAATTCCAGTTTGAGAATTTA	0.244													C	90024361	C	C	90024361	2	2	144	1	0	0	0	0	0	0	0	1	1139	1838	64	4		4	ATP2B1	12	90024361	Silent	SNP	T	TCGA-14-3476-01B-01D-1353-08	78517608	90024361	43827534	63	9896											
IGF1	3479	broad.mit.edu	37	chr12	102869429	102869429	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agggctacttactgaaataaAagcccctgtctccacacacg	7	13	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr12:102869429A>C	uc001tjp.3	-	2	431	c.212T>G	c.(211-213)TTT>TGT	p.F71C	IGF1_uc001tjn.2_Missense_Mutation_p.F55C|IGF1_uc001tjm.2_Missense_Mutation_p.F71C|IGF1_uc001tjo.2_Missense_Mutation_p.F71C	NM_001111285	NP_001104755	P05019	IGF1_HUMAN	insulin-like growth factor 1 isoform 3	71	B.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2						ACTGAAATAAAAGCCCCTGTC	0.537													C	102869429	C	C	102869429	3	2	144	1	0	0	0	0	1	0	0	0	7570	14	1	5	451	5	IGF1	12	102869429	Missense_Mutation	SNP	A	TCGA-14-3476-01B-01D-1353-08	12845068	102869429	30982466	64	9897											
ANAPC7	51434	broad.mit.edu	37	chr12	110825638	110825638	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccaagttaggcacggtttGgatcacattcattgtcatgg	11	8	3	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr12:110825638G>A	uc001tqo.2	-	5	683	c.682C>T	c.(682-684)CAA>TAA	p.Q228*	ANAPC7_uc001tqp.3_Nonsense_Mutation_p.Q228*	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	228					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						GGCACGGTTTGGATCACATTC	0.463													A	110825638	A	A	110825638	4	1	144	1	0	0	0	0	0	1	0	0	606	1357	47	3	1149	3	ANAPC7	12	110825638	Nonsense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	7956209	110825638	23026257	65	9898											
PTPN11	5781	broad.mit.edu	37	chr12	112926900	112926900	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaggtcagggatggtccagaCagaagcacagtaccgattta	13	8	1	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr12:112926900C>A	uc001ttx.2	+	13	1900	c.1520C>A	c.(1519-1521)ACA>AAA	p.T507K		NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	511	Tyrosine-protein phosphatase.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding	p.T507K(3)		haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						ATGGTCCAGACAGAAGCACAG	0.478			Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				A	112926900	A	A	112926900	3	1	144	1	0	0	0	0	1	0	0	0	12780	478	17	5	1570	5	PTPN11	12	112926900	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	2101262	112926900	20924995	66	9899											
RBM19	9904	broad.mit.edu	37	chr12	114383718	114383718	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gccccatgaatagtgtgttcCagttgtgagagctaagaggc	13	8	0	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr12:114383718C>A	uc009zwi.2	-	13	1685	c.1541G>T	c.(1540-1542)TGG>TTG	p.W514L	RBM19_uc001tvn.3_Missense_Mutation_p.W514L|RBM19_uc001tvm.2_Missense_Mutation_p.W514L	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	514					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TAGTGTGTTCCAGTTGTGAGA	0.542													A	114383718	A	A	114383718	3	1	144	1	0	0	0	0	1	0	0	0	13121	595	21	5	1389	5	RBM19	12	114383718	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	1456818	114383718	19468177	67	9900											
TCTN2	79867	broad.mit.edu	37	chr12	124175182	124175182	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactataccaagaacgagatGgtattatcaatgcgaagata	8	6	1	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr12:124175182G>A	uc001ufp.2	+	8	1122	c.994G>A	c.(994-996)GGT>AGT	p.G332S	TCTN2_uc009zya.2_Missense_Mutation_p.G331S	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	332	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		AGAACGAGATGGTATTATCAA	0.388													A	124175182	A	A	124175182	3	1	144	1	0	0	0	0	1	0	0	0	15720	1348	47	3	1024	3	TCTN2	12	124175182	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	9791464	124175182	9676713	68	9901											
NCOR2	9612	broad.mit.edu	37	chr12	124915195	124915195	+	Frame_Shift_Del	DEL	G	-	-													ctgcagctcgcgctgcttgcGgatctcagggaactgcttct							TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr12:124915195delG	uc010tba.1	-	9	1138	c.1021delC	c.(1021-1023)CGCfs	p.R341fs	NCOR2_uc010tay.1_Frame_Shift_Del_p.R341fs|NCOR2_uc010taz.1_Frame_Shift_Del_p.R341fs|NCOR2_uc010tbb.1_Frame_Shift_Del_p.R341fs|NCOR2_uc010tbc.1_Frame_Shift_Del_p.R341fs|NCOR2_uc001ugj.1_Frame_Shift_Del_p.R341fs|NCOR2_uc001ugk.1_Frame_Shift_Del_p.R341fs	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	341					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CGCTGCTTGCGGATCTCAGGG	0.672													-	124915195	-	-	124915195	7	5	144	1	0	1	0	1	0	0	0	0	10236	1116	39	0	6703	0	NCOR2	12	124915195	Frame_Shift_Del	DEL	G	TCGA-14-3476-01B-01D-1353-08	740013	124915195	8936700	69	9902											
HSPH1	10808	broad.mit.edu	37	chr13	31713139	31713139	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggggagaaaacgacctaccaTtaattcttccaacttgtcaa	7	10	2	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr13:31713139T>A	uc001utj.2	-	15	2484	c.2086A>T	c.(2086-2088)ATG>TTG	p.M696L	HSPH1_uc001utk.2_Missense_Mutation_p.M652L|HSPH1_uc010aaw.2_Missense_Mutation_p.M655L|HSPH1_uc001utl.2_Missense_Mutation_p.M698L|HSPH1_uc010tds.1_Missense_Mutation_p.M620L	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	696					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		CGACCTACCATTAATTCTTCC	0.299													A	31713139	A	A	31713139	3	1	144	1	0	0	0	0	1	0	0	0	7431	1493	52	5	506	5	HSPH1	13	31713139	Missense_Mutation	SNP	T	TCGA-14-3476-01B-01D-1353-08		31713139	83456739	70	9903											
CCDC70	83446	broad.mit.edu	37	chr13	52439731	52439731	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggaagagatgtggactttcCgaggcaagatccatgctttc	13	8	0	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr13:52439731C>T	uc001vfu.3	+	2	513	c.217C>T	c.(217-219)CGA>TGA	p.R73*	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	73						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		GTGGACTTTCCGAGGCAAGAT	0.458													T	52439731	T	T	52439731	4	4	144	1	0	0	0	0	0	1	0	0	2843	644	23	2	219	2	CCDC70	13	52439731	Nonsense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	20726592	52439731	62730147	71	9904											
MUDENG	55745	broad.mit.edu	37	chr14	57741370	57741370	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaattgagccagttgcctgaCttgcttctgcaggcttgtcc	10	11	1	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr14:57741370C>A	uc001xcv.2	+	2	910	c.483C>A	c.(481-483)GAC>GAA	p.D161E	MUDENG_uc001xcu.3_Missense_Mutation_p.D161E|MUDENG_uc010tri.1_Intron|MUDENG_uc010trj.1_Missense_Mutation_p.D58E	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	161					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						AGTTGCCTGACTTGCTTCTGC	0.368													A	57741370	A	A	57741370	3	1	144	1	0	0	0	0	1	0	0	0	9983	564	20	5	489	5	MUDENG	14	57741370	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08		57741370	49608170	72	9905											
BCL11B	64919	broad.mit.edu	37	chr14	99641920	99641920	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctggcggctgcgggggcGgcgtgccgccagggggcatg	23	11	0	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr14:99641920G>A	uc001yga.2	-	4	1520	c.1253C>T	c.(1252-1254)CCG>CTG	p.P418L	BCL11B_uc001ygb.2_Missense_Mutation_p.P347L	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	418						nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CTGCGGGGGCGGCGTGCCGCC	0.687			T	TLX3	T-ALL								A	99641920	A	A	99641920	3	1	144	1	0	0	0	0	1	0	0	0	1364	1116	39	2	1435	2	BCL11B	14	99641920	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	41900550	99641920	7707620	73	9906											
GABRB3	2562	broad.mit.edu	37	chr15	26828530	26828530	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccagggggtatctcctgaGgtccatcatgcatgctgctg	13	11	2	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr15:26828530G>A	uc001zaz.2	-	5	635	c.493C>T	c.(493-495)CTC>TTC	p.L165F	GABRB3_uc010uae.1_Missense_Mutation_p.L80F|GABRB3_uc001zba.2_Missense_Mutation_p.L165F|GABRB3_uc001zbb.2_Missense_Mutation_p.L221F	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	165	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TATCTCCTGAGGTCCATCATG	0.453													A	26828530	A	A	26828530	3	1	144	1	0	0	0	0	1	0	0	0	6168	1000	35	3	948	3	GABRB3	15	26828530	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08		26828530	75702862	74	9907											
ZNF770	54989	broad.mit.edu	37	chr15	35274803	35274803	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	caagtggattattctcctcaGattcaccaatctcaccattt	4	12	4	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr15:35274803G>C	uc001ziw.2	-	3	1144	c.833C>G	c.(832-834)TCT>TGT	p.S278C		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		ATTCTCCTCAGATTCACCAAT	0.388													C	35274803	C	C	35274803	3	2	144	1	0	0	0	0	1	0	0	0	18140	942	33	5	1246	5	ZNF770	15	35274803	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	8446273	35274803	67256589	75	9908											
UACA	55075	broad.mit.edu	37	chr15	70957092	70957092	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggttcccacttgtgtaggtgAgttgggaaaggccattgagt	15	6	0	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr15:70957092A>T	uc002asr.2	-	17	4126	c.4022T>A	c.(4021-4023)CTC>CAC	p.L1341H	UACA_uc010uke.1_Missense_Mutation_p.L1232H|UACA_uc002asq.2_Missense_Mutation_p.L1328H	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	1341	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						TGTGTAGGTGAGTTGGGAAAG	0.433													T	70957092	T	T	70957092	3	4	144	1	0	0	0	0	1	0	0	0	16821	304	11	5	240	5	UACA	15	70957092	Missense_Mutation	SNP	A	TCGA-14-3476-01B-01D-1353-08	35682289	70957092	31574300	76	9909											
C16orf45	89927	broad.mit.edu	37	chr16	15609227	15609227	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggagattgagctggagatgGcaaaaattcagcgtctccgg	14	7	2	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr16:15609227G>A	uc002ddo.2	+	2	358	c.172G>A	c.(172-174)GCA>ACA	p.A58T	C16orf45_uc002ddp.2_Missense_Mutation_p.A41T	NM_033201	NP_149978	Q96MC5	CP045_HUMAN	hypothetical protein LOC89927 isoform 1	58										ovary(1)	1						GCTGGAGATGGCAAAAATTCA	0.527													A	15609227	A	A	15609227	3	1	144	1	0	0	0	0	1	0	0	0	1814	1203	42	3	237	3	C16orf45	16	15609227	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08		15609227	74745526	77	9910											
ATP2A1	487	broad.mit.edu	37	chr16	28913648	28913648	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcatggaccgccccccccGgagccccaaggagcccctca	9	21	2	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr16:28913648G>A	uc002dro.1	+	17	2649	c.2465G>A	c.(2464-2466)CGG>CAG	p.R822Q	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.R822Q|ATP2A1_uc002drp.1_Missense_Mutation_p.R697Q	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	822	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CGCCCCCCCCGGAGCCCCAAG	0.657													A	28913648	A	A	28913648	3	1	144	1	0	0	0	0	1	0	0	0	1136	1116	39	2	2531	2	ATP2A1	16	28913648	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	13304421	28913648	61441105	78	9911											
DHRS7C	201140	broad.mit.edu	37	chr17	9684903	9684903	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cccacctgtgtggaacacccGagcacactctgtggggaaga	12	13	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr17:9684903G>A	uc010vvb.1	-	2	163	c.163C>T	c.(163-165)CGG>TGG	p.R55W	DHRS7C_uc010cof.2_Missense_Mutation_p.R55W	NM_001105571	NP_001099041	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	55	NAD or NADP (By similarity).					extracellular region	binding|oxidoreductase activity				0						TGGAACACCCGAGCACACTCT	0.547													A	9684903	A	A	9684903	3	1	144	1	0	0	0	0	1	0	0	0	4497	1057	37	2	792	2	DHRS7C	17	9684903	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08		9684903	71510307	79	9912											
MAP2K3	5606	broad.mit.edu	37	chr17	21206533	21206533	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catctgcacagcaagctgtcGgtgatccacagaggtcagtg	12	11	2	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr17:21206533G>A	uc002gys.2	+	7	820	c.555G>A	c.(553-555)TCG>TCA	p.S185S	MAP2K3_uc002gyt.2_Silent_p.S156S|MAP2K3_uc002gyu.2_Silent_p.S156S	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	185	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GCAAGCTGTCGGTGATCCACA	0.622													A	21206533	A	A	21206533	2	1	144	1	0	0	0	0	0	0	0	1	9238	1103	39	2		2	MAP2K3	17	21206533	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08	11521630	21206533	59988677	80	9913											
MYO18A	399687	broad.mit.edu	37	chr17	27422043	27422043	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagcttctcccgctgggCctcctcatgcgcctgcgaga	11	17	2	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr17:27422043C>A	uc002hdt.1	-	29	4578	c.4420G>T	c.(4420-4422)GCC>TCC	p.A1474S	MYO18A_uc010wbc.1_Missense_Mutation_p.A1016S|MYO18A_uc002hds.2_Missense_Mutation_p.A1016S|MYO18A_uc010csa.1_Missense_Mutation_p.A1474S|MYO18A_uc002hdu.1_Missense_Mutation_p.A1474S|MYO18A_uc010wbd.1_Missense_Mutation_p.A1143S	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1474	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TCCCGCTGGGCCTCCTCATGC	0.627													A	27422043	A	A	27422043	3	1	144	1	0	0	0	0	1	0	0	0	10065	739	26	5	1800	5	MYO18A	17	27422043	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	6215510	27422043	53773167	81	9914											
IKZF3	22806	broad.mit.edu	37	chr17	37922611	37922611	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggtgtctggaccaaggggCgcagggcttcggcgccaaga	18	11	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr17:37922611C>T	uc002hsu.2	-	8	1024	c.962G>A	c.(961-963)CGC>CAC	p.R321H	IKZF3_uc002htd.2_Missense_Mutation_p.R287H|IKZF3_uc010cwd.2_Missense_Mutation_p.R178H|IKZF3_uc002hsv.2_Missense_Mutation_p.R248H|IKZF3_uc010cwe.2_Missense_Mutation_p.R187H|IKZF3_uc010cwf.2_Missense_Mutation_p.R139H|IKZF3_uc010cwg.2_Missense_Mutation_p.R100H|IKZF3_uc002hsw.2_Missense_Mutation_p.R282H|IKZF3_uc002hsx.2_Missense_Mutation_p.R265H|IKZF3_uc002hsy.2_Missense_Mutation_p.R282H|IKZF3_uc002hsz.2_Missense_Mutation_p.R226H|IKZF3_uc002hta.2_Missense_Mutation_p.R243H|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Missense_Mutation_p.R234H|IKZF3_uc002htc.2_Missense_Mutation_p.R74H|IKZF3_uc010wel.1_Missense_Mutation_p.R74H	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	321				R -> C (in Ref. 1; AAF13493 and 2; CAC80427/CAC80428/CAC80429/CAC80430/ CAC80431).	B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GACCAAGGGGCGCAGGGCTTC	0.547													T	37922611	T	T	37922611	3	4	144	1	0	0	0	0	1	0	0	0	7616	768	27	1	571	1	IKZF3	17	37922611	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	10500568	37922611	43272599	82	9915											
APCDD1	147495	broad.mit.edu	37	chr18	10471619	10471619	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaccaattttattatggcaGcaaccggtgcacaaatccca	6	12	0	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr18:10471619G>A	uc002kom.3	+	3	689	c.335G>A	c.(334-336)AGC>AAC	p.S112N		NM_153000	NP_694545	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	112	Extracellular (Potential).				hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding				0				READ - Rectum adenocarcinoma(15;0.08)		TATTATGGCAGCAACCGGTGC	0.532													A	10471619	A	A	10471619	3	1	144	1	0	0	0	0	1	0	0	0	765	971	34	3	345	3	APCDD1	18	10471619	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08		10471619	67605629	83	9916											
MUC16	94025	broad.mit.edu	37	chr19	9084743	9084743	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggggagctcatttgttttccGtgcgtcaaggatatctgagg	14	7	3	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr19:9084743G>T	uc002mkp.2	-	1	7276	c.7072C>A	c.(7072-7074)CGG>AGG	p.R2358R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2358	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.R2358P(1)		lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTTGTTTTCCGTGCGTCAAGG	0.433													T	9084743	T	T	9084743	2	4	144	1	0	0	0	0	0	0	0	1	9973	1144	40	5		5	MUC16	19	9084743	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08		9084743	50044240	84	9917											
SMARCA4	6597	broad.mit.edu	37	chr19	11136160	11136160	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcggaagatctgcaaccaCccctacatgttccagcacat	7	15	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr19:11136160C>T	uc002mqf.3	+	22	3428	c.3144C>T	c.(3142-3144)CAC>CAT	p.H1048H	SMARCA4_uc010dxp.2_Silent_p.H1048H|SMARCA4_uc010dxo.2_Silent_p.H1048H|SMARCA4_uc002mqg.1_Silent_p.H1048H|SMARCA4_uc010dxq.2_Silent_p.H1048H|SMARCA4_uc010dxr.2_Silent_p.H1048H|SMARCA4_uc002mqj.3_Silent_p.H1048H|SMARCA4_uc010dxs.2_Silent_p.H1048H|SMARCA4_uc010dxt.1_Silent_p.H268H|SMARCA4_uc002mqh.3_Silent_p.H171H|SMARCA4_uc002mqi.1_Silent_p.H251H	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1048					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TCTGCAACCACCCCTACATGT	0.617			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				T	11136160	T	T	11136160	2	4	144	1	0	0	0	0	0	0	0	1	14770	506	18	3		3	SMARCA4	19	11136160	Silent	SNP	C	TCGA-14-3476-01B-01D-1353-08	2051417	11136160	47992823	85	9918											
CCDC8	83987	broad.mit.edu	37	chr19	46915568	46915568	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacgcggcggcgggcaggcGgcgcgctgggctgcttctcc	19	14	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr19:46915568G>A	uc002pep.2	-	1	1352	c.500C>T	c.(499-501)CCG>CTG	p.P167L		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	167						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		GCGGGCAGGCGGCGCGCTGGG	0.647													A	46915568	A	A	46915568	3	1	144	1	0	0	0	0	1	0	0	0	2853	1116	39	2	1120	2	CCDC8	19	46915568	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	35779408	46915568	12213415	86	9919											
PRKCG	5582	broad.mit.edu	37	chr19	54401216	54401216	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttctcctttccacagcggGtgcggatgggcccctcttcc	10	16	2	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr19:54401216G>A	uc002qcq.1	+	10	1225	c.943G>A	c.(943-945)GTG>ATG	p.V315M	PRKCG_uc010yef.1_Silent_p.G285G|PRKCG_uc010yeg.1_Missense_Mutation_p.V315M|PRKCG_uc010yeh.1_Missense_Mutation_p.V202M	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	315				RVRM -> VSRT (in Ref. 3; AAA60102).	activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TCCACAGCGGGTGCGGATGGG	0.468													A	54401216	A	A	54401216	3	1	144	1	0	0	0	0	1	0	0	0	12512	1261	44	3	981	3	PRKCG	19	54401216	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	7485648	54401216	4727767	87	9920											
KIR3DL1	3811	broad.mit.edu	37	chr19	55378070	55378070	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcagtcgcccttctcagaggCccaagacacccctaacagat	7	16	2	3			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr19:55378070C>A	uc002qhl.3	+	9	1315	c.1252C>A	c.(1252-1254)CCC>ACC	p.P418T	KIR3DL2_uc010esh.2_Missense_Mutation_p.P401T|KIR3DL2_uc002qho.3_Missense_Mutation_p.P418T			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	418	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		TTCTCAGAGGCCCAAGACACC	0.522													A	55378070	A	A	55378070	3	1	144	1	0	0	0	0	1	0	0	0	8320	739	26	5		5	KIR3DL1	19	55378070	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	976854	55378070	3750913	88	9921											
NLRP7	199713	broad.mit.edu	37	chr19	55451740	55451740	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgttggtttctcagagtgacGtcgtcatggaaattgtcaat	11	7	3	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr19:55451740G>A	uc002qih.3	-	4	523	c.447C>T	c.(445-447)GAC>GAT	p.D149D	NLRP7_uc002qig.3_Silent_p.D149D|NLRP7_uc002qii.3_Silent_p.D149D|NLRP7_uc010esk.2_Silent_p.D149D|NLRP7_uc010esl.2_Silent_p.D177D	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	149							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TCAGAGTGACGTCGTCATGGA	0.498													A	55451740	A	A	55451740	2	1	144	1	0	0	0	0	0	0	0	1	10482	1136	40	1		1	NLRP7	19	55451740	Silent	SNP	G	TCGA-14-3476-01B-01D-1353-08	73670	55451740	3677243	89	9922											
NLRP4	147945	broad.mit.edu	37	chr19	56382210	56382210	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taggttggctttctgccaccTcagcgagcagtgctgcgaat	12	11	2	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr19:56382210T>C	uc002qmd.3	+	7	2794	c.2372T>C	c.(2371-2373)CTC>CCC	p.L791P	NLRP4_uc002qmf.2_Missense_Mutation_p.L716P|NLRP4_uc010etf.2_Missense_Mutation_p.L566P	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	791							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TTCTGCCACCTCAGCGAGCAG	0.498													C	56382210	C	C	56382210	3	2	144	1	0	0	0	0	1	0	0	0	10479	1551	54	4	2394	4	NLRP4	19	56382210	Missense_Mutation	SNP	T	TCGA-14-3476-01B-01D-1353-08	930470	56382210	2746773	90	9923											
SLC7A4	6545	broad.mit.edu	37	chr22	21384419	21384419	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actggtggccacgaatgtgtAggccaggagtgtgccaaggg	17	8	0	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr22:21384419A>G	uc002zud.2	-	3	1272	c.1204T>C	c.(1204-1206)TAC>CAC	p.Y402H	SLC7A4_uc002zue.2_Missense_Mutation_p.Y402H	NM_004173	NP_004164	O43246	CTR4_HUMAN	solute carrier family 7 (cationic amino acid	402	Helical; (Potential).				cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			ovary(1)|lung(1)	2	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	ACGAATGTGTAGGCCAGGAGT	0.657													G	21384419	G	G	21384419	3	3	144	1	0	0	0	0	1	0	0	0	14699	420	15	4	715	4	SLC7A4	22	21384419	Missense_Mutation	SNP	A	TCGA-14-3476-01B-01D-1353-08		21384419	29920147	91	9924											
RRP7A	27341	broad.mit.edu	37	chr22	42910784	42910784	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgcgtagtcactgatccaCtctgaggaaaagggagccag	12	10	3	2	rs146741450	by1000genomes	TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr22:42910784C>T	uc003bcq.2	-	5	478	c.462G>A	c.(460-462)AAG>AAA	p.K154K	SERHL_uc011apm.1_Intron|RRP7A_uc003bcp.2_Silent_p.K177K	NM_015703	NP_056518	Q9Y3A4	RRP7A_HUMAN	ribosomal RNA processing 7 homolog A	154							nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2						CACTGATCCACTCTGAGGAAA	0.602													T	42910784	T	T	42910784	2	4	144	1	0	0	0	0	0	0	0	1	13689	579	20	3		3	RRP7A	22	42910784	Silent	SNP	C	TCGA-14-3476-01B-01D-1353-08	21526365	42910784	8393782	92	9925											
MOV10L1	54456	broad.mit.edu	37	chr22	50596619	50596619	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcgacattggcgtcatcaCgccctaccggaagcaggtac	11	14	2	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chr22:50596619C>T	uc003bjj.2	+	23	3283	c.3200C>T	c.(3199-3201)ACG>ATG	p.T1067M	MOV10L1_uc003bjk.3_Missense_Mutation_p.T1067M|MOV10L1_uc011arp.1_Missense_Mutation_p.T1047M|MOV10L1_uc003bjl.2_Missense_Mutation_p.T194M|MOV10L1_uc003bjm.1_Missense_Mutation_p.T110M	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	1067					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GGCGTCATCACGCCCTACCGG	0.657													T	50596619	T	T	50596619	3	4	144	1	0	0	0	0	1	0	0	0	9719	536	19	1	3343	1	MOV10L1	22	50596619	Missense_Mutation	SNP	C	TCGA-14-3476-01B-01D-1353-08	7685835	50596619	707947	93	9926											
SHROOM2	357	broad.mit.edu	37	chrX	9905429	9905429	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggcccagccggctgagccCcagcccctgggcacccaggt	14	18	0	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chrX:9905429C>T	uc004csu.1	+	7	3933	c.3843C>T	c.(3841-3843)CCC>CCT	p.P1281P	SHROOM2_uc004csv.2_Silent_p.P116P|SHROOM2_uc011mic.1_Silent_p.P116P|SHROOM2_uc004csw.1_Silent_p.P116P	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1281					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CGGCTGAGCCCCAGCCCCTGG	0.642													T	9905429	T	T	9905429	2	4	144	1	0	0	0	0	0	0	0	1	14294	610	22	3		3	SHROOM2	23	9905429	Silent	SNP	C	TCGA-14-3476-01B-01D-1353-08		9905429	145365131	94	9927											
SRPX	8406	broad.mit.edu	37	chrX	38009054	38009054	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcaggttgaacagggccacAggcatcaccagggagacata	12	10	2	2			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chrX:38009054A>G	uc004ddy.1	-	10	1391	c.1305T>C	c.(1303-1305)CCT>CCC	p.P435P	SRPX_uc004ddz.1_Silent_p.P415P|SRPX_uc011mkh.1_Silent_p.P376P|SRPX_uc011mki.1_3'UTR	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	435					cell adhesion	cell surface|membrane					0						ACAGGGCCACAGGCATCACCA	0.502													G	38009054	G	G	38009054	2	3	144	1	0	0	0	0	0	0	0	1	15163	175	7	4		4	SRPX	23	38009054	Silent	SNP	A	TCGA-14-3476-01B-01D-1353-08	28103625	38009054	117261506	95	9928											
WDR45	11152	broad.mit.edu	37	chrX	48935362	48935362	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaggccagaaggttggagcGgtgcagcatctccaccaagc	13	12	1	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chrX:48935362G>A	uc004dmk.1	-	4	347	c.175C>T	c.(175-177)CGC>TGC	p.R59C	PRAF2_uc011mmt.1_Intron|WDR45_uc004dmj.1_Missense_Mutation_p.R9C|WDR45_uc004dml.1_Missense_Mutation_p.R59C|WDR45_uc004dmm.1_Intron|WDR45_uc010nim.1_Missense_Mutation_p.R59C|WDR45_uc004dmn.1_5'UTR|WDR45_uc004dmo.1_Missense_Mutation_p.R81C|WDR45_uc004dmp.1_Missense_Mutation_p.R59C|WDR45_uc011mmu.1_Missense_Mutation_p.R59C	NM_001029896	NP_001025067	Q9Y484	WIPI4_HUMAN	WD repeat domain 45 isoform 2	59					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1						AGGTTGGAGCGGTGCAGCATC	0.607													A	48935362	A	A	48935362	3	1	144	1	0	0	0	0	1	0	0	0	17294	1116	39	2	942	2	WDR45	23	48935362	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	10926308	48935362	106335198	96	9929											
OPN1LW	5956	broad.mit.edu	37	chrX	153416186	153416186	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgggtgtaccacctcaccagTgtctggatgatctttgtggt	12	9	3	1			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chrX:153416186T>C	uc004fjz.3	+	2	204	c.171T>C	c.(169-171)AGT>AGC	p.S57S		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	57	Helical; Name=1; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCTCACCAGTGTCTGGATGA	0.587													C	153416186	C	C	153416186	2	2	144	1	0	0	0	0	0	0	0	1	10877	1693	59	4		4	OPN1LW	23	153416186	Silent	SNP	T	TCGA-14-3476-01B-01D-1353-08	104480824	153416186	1854374	97	9930											
RPL10	6134	broad.mit.edu	37	chrX	153628824	153628824	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctccaaacaggcatgcgaGgtgcctttggaaagccccag	13	12	0	0			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chrX:153628824G>A	uc004fkm.2	+	6	537	c.349G>A	c.(349-351)GGT>AGT	p.G117S	uc010nuv.1_5'Flank|RPL10_uc004fko.2_Intron|RPL10_uc004fkn.1_Missense_Mutation_p.G117S|RPL10_uc004fkp.1_3'UTR|RPL10_uc004fkq.1_Intron|RPL10_uc004fkr.1_Missense_Mutation_p.G42S	NM_006013	NP_006004	P27635	RL10_HUMAN	ribosomal protein L10	117					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGGCATGCGAGGTGCCTTTGG	0.527													A	153628824	A	A	153628824	3	1	144	1	0	0	0	0	1	0	0	0	13554	1000	35	3	367	3	RPL10	23	153628824	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	212638	153628824	1641736	98	9931											
VAMP7	6845	broad.mit.edu	37	chrX	155130194	155130194	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaataagggcctagacaaaGtgatggagactcaagcccaa	11	8	1	4			TCGA-14-3476-01B-01D-1353-08	TCGA-14-3476-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	37f51be9-2c41-476e-b153-c5c0a52c3d2f	03da9810-f78d-4eec-bd34-20fc79a57fd6	g.chrX:155130194G>T	uc004fnr.2	+	5	550	c.376G>T	c.(376-378)GTG>TTG	p.V126L	VAMP7_uc004fnt.2_Missense_Mutation_p.V85L|VAMP7_uc011naa.1_Missense_Mutation_p.V87L|VAMP7_uc011nab.1_Missense_Mutation_p.V25L|VAMP7_uc004fns.2_Missense_Mutation_p.V126L|VAMP7_uc011nac.1_Missense_Mutation_p.V59L	NM_005638	NP_005629	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7 isoform 1	126	v-SNARE coiled-coil homology.|Cytoplasmic (Potential).				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCTAGACAAAGTGATGGAGAC	0.358													T	155130194	T	T	155130194	3	4	144	1	0	0	0	0	1	0	0	0	17114	1029	36	5	390	5	VAMP7	23	155130194	Missense_Mutation	SNP	G	TCGA-14-3476-01B-01D-1353-08	1501370	155130194	140366	99	9932											
HSPG2	3339	broad.mit.edu	37	chr1	22211272	22211272	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagtacctcgttgtgggaCgagctcaaggacaccgtcag	14	11	2	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr1:22211272C>T	uc001bfj.2	-	12	1535	c.1495G>A	c.(1495-1497)GTC>ATC	p.V499I	HSPG2_uc009vqd.2_Missense_Mutation_p.V499I	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	499	Ig-like C2-type 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGTTGTGGGACGAGCTCAAGG	0.667													T	22211272	T	T	22211272	3	4	145	1	0	0	0	0	1	0	0	0	7430	536	19	1	12024	1	HSPG2	1	22211272	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08		22211272	227039349	1	9933											
DAB1	1600	broad.mit.edu	37	chr1	57535043	57535043	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aattttatacctgataaatgTtttcttccgtttcgggatca	6	7	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr1:57535043T>A	uc001cys.1	-	10	1327	c.653A>T	c.(652-654)AAC>ATC	p.N218I	DAB1_uc001cyt.1_Missense_Mutation_p.N218I|DAB1_uc001cyq.1_Intron|DAB1_uc001cyr.1_Intron|DAB1_uc009vzw.1_Intron|DAB1_uc009vzx.1_Missense_Mutation_p.N218I	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	218					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CTGATAAATGTTTTCTTCCGT	0.423													A	57535043	A	A	57535043	3	1	145	1	0	0	0	0	1	0	0	0	4217	1725	60	5	1042	5	DAB1	1	57535043	Missense_Mutation	SNP	T	TCGA-14-4157-01A-01D-1353-08	35323771	57535043	191715578	2	9934											
GBP2	2634	broad.mit.edu	37	chr1	89575480	89575482	+	In_Frame_Del	DEL	CTC	-	-													ttctctttctgttccatcatCtcctcattcttcttttgtat							TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr1:89575480_89575482delCTC	uc001dmz.1	-	10	1808_1810	c.1537_1539delGAG	c.(1537-1539)GAGdel	p.E513del	GBP2_uc001dmy.1_RNA	NM_004120	NP_004111	P32456	GBP2_HUMAN	guanylate binding protein 2,	513					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		GTTCCATCATCTCCTCATTCTTC	0.404													-	89575482	-	-	89575480	7	5	145	1	0	1	0	1	0	0	0	0	6274	912	32	0	244	0	GBP2	1	89575480	In_Frame_Del	DEL	CTC	TCGA-14-4157-01A-01D-1353-08	32040437	89575480	159675141	3	9935											
DCLRE1B	64858	broad.mit.edu	37	chr1	114448263	114448263	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtggacttctggagcctgCgccgggctggcaccgcacgt	15	14	1	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr1:114448263C>T	uc001eeg.2	+	1	226	c.55C>T	c.(55-57)CGC>TGC	p.R19C	AP4B1_uc001eeb.2_5'Flank|AP4B1_uc001eec.2_5'Flank|AP4B1_uc001eed.2_5'Flank|AP4B1_uc010owp.1_5'Flank|AP4B1_uc010owq.1_5'Flank|DCLRE1B_uc001eeh.2_5'UTR|DCLRE1B_uc001eei.2_5'UTR	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	19					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGGAGCCTGCGCCGGGCTGG	0.642								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					T	114448263	T	T	114448263	3	4	145	1	0	0	0	0	1	0	0	0	4295	768	27	1	57	1	DCLRE1B	1	114448263	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	24872783	114448263	134802358	4	9936											
CASQ2	845	broad.mit.edu	37	chr1	116247851	116247851	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gtcgatccacaggatgctcaGatcggggttgtcagtattgt	13	8	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr1:116247851G>C	uc001efx.3	-	9	1165	c.901C>G	c.(901-903)CTG>GTG	p.L301V	CASQ2_uc010owu.1_Missense_Mutation_p.L230V	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	301					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		AGGATGCTCAGATCGGGGTTG	0.547													C	116247851	C	C	116247851	3	2	145	1	0	0	0	0	1	0	0	0	2681	933	33	5	310	5	CASQ2	1	116247851	Missense_Mutation	SNP	G	TCGA-14-4157-01A-01D-1353-08	1799588	116247851	133002770	5	9937											
PRSS38	339501	broad.mit.edu	37	chr1	228004940	228004940	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcaaaatctatgacatgtaCgtaggcctcgtaaacctcag	7	10	3	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr1:228004940C>T	uc001hrh.2	+	3	342	c.342C>T	c.(340-342)TAC>TAT	p.Y114Y		NM_183062	NP_898885	A1L453	PRS38_HUMAN	marapsin 2 precursor	114	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)|pancreas(1)	2						ATGACATGTACGTAGGCCTCG	0.562													T	228004940	T	T	228004940	2	4	145	1	0	0	0	0	0	0	0	1	12627	547	19	1		1	PRSS38	1	228004940	Silent	SNP	C	TCGA-14-4157-01A-01D-1353-08	111757089	228004940	21245681	6	9938											
LYST	1130	broad.mit.edu	37	chr1	235866238	235866238	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctagcgctcgtctctgaaCtggatcttcaactgcagaga	9	11	4	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr1:235866238C>T	uc001hxj.2	-	45	10358	c.10183G>A	c.(10183-10185)GTT>ATT	p.V3395I	LYST_uc001hxi.2_Missense_Mutation_p.V619I	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3395	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CGTCTCTGAACTGGATCTTCA	0.448									Chediak-Higashi_syndrome				T	235866238	T	T	235866238	3	4	145	1	0	0	0	0	1	0	0	0	9128	565	20	3	1258	3	LYST	1	235866238	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	7861298	235866238	13384383	7	9939											
HEATR1	55127	broad.mit.edu	37	chr1	236749663	236749663	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taaccataaatggcagcaaaCatacaaccacctgatttgac	5	11	0	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr1:236749663C>A	uc001hyd.1	-	15	1930	c.1805G>T	c.(1804-1806)TGT>TTT	p.C602F		NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	602					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TGGCAGCAAACATACAACCAC	0.358													A	236749663	A	A	236749663	3	1	145	1	0	0	0	0	1	0	0	0	7027	478	17	5	4753	5	HEATR1	1	236749663	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	883425	236749663	12500958	8	9940											
FOSL2	2355	broad.mit.edu	37	chr2	28635026	28635026	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccctggaagaggacagccCctcgtcctcgtcggcggggc	15	16	0	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr2:28635026C>T	uc002rma.2	+	4	1501	c.692C>T	c.(691-693)CCC>CTC	p.P231L	FOSL2_uc010ymi.1_Missense_Mutation_p.P192L	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	231					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					GAGGACAGCCCCTCGTCCTCG	0.692													T	28635026	T	T	28635026	3	4	145	1	0	0	0	0	1	0	0	0	5988	623	22	3	706	3	FOSL2	2	28635026	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08		28635026	214564347	9	9941											
THADA	63892	broad.mit.edu	37	chr2	43520122	43520122	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcttccagtgttagtgagcGcacttcagggaaggcagatt	14	8	1	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr2:43520122G>A	uc002rsw.3	-	32	5021	c.4669C>T	c.(4669-4671)CGC>TGC	p.R1557C	THADA_uc010far.2_Missense_Mutation_p.R752C|THADA_uc002rsx.3_Missense_Mutation_p.R1557C|THADA_uc002rsy.3_RNA	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1557							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GTTAGTGAGCGCACTTCAGGG	0.557													A	43520122	A	A	43520122	3	1	145	1	0	0	0	0	1	0	0	0	15837	1087	38	1	1220	1	THADA	2	43520122	Missense_Mutation	SNP	G	TCGA-14-4157-01A-01D-1353-08	14885096	43520122	199679251	10	9942											
FSHR	2492	broad.mit.edu	37	chr2	49190747	49190747	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgcagagatcagcaaaggCcaggttgcacataaggaacc	11	9	1	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr2:49190747C>T	uc002rww.2	-	10	1287	c.1213G>A	c.(1213-1215)GCC>ACC	p.A405T	FSHR_uc002rwx.2_Missense_Mutation_p.A343T|FSHR_uc010fbn.2_Missense_Mutation_p.A379T	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	405	Helical; Name=2; (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TCAGCAAAGGCCAGGTTGCAC	0.458									Gonadal_Dysgenesis_46_XX				T	49190747	T	T	49190747	3	4	145	1	0	0	0	0	1	0	0	0	6073	739	26	3	878	3	FSHR	2	49190747	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	5670625	49190747	194008626	11	9943											
CTNNA2	1496	broad.mit.edu	37	chr2	80085194	80085194	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatgacccttgctcgtcggtAaagcgcggcaccatggtacg	13	12	0	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr2:80085194A>C	uc010ysh.1	+	3	359	c.354A>C	c.(352-354)GTA>GTC	p.V118V	CTNNA2_uc010yse.1_Silent_p.V118V|CTNNA2_uc010ysf.1_Silent_p.V118V|CTNNA2_uc010ysg.1_Silent_p.V118V	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	118					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GCTCGTCGGTAAAGCGCGGCA	0.582													C	80085194	C	C	80085194	2	2	145	1	0	0	0	0	0	0	0	1	4013	349	13	5		5	CTNNA2	2	80085194	Silent	SNP	A	TCGA-14-4157-01A-01D-1353-08	30894447	80085194	163114179	12	9944											
SLC9A2	6549	broad.mit.edu	37	chr2	103274233	103274233	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccattctttgagaacattgGcacgattttctggtatgctg	9	9	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr2:103274233G>C	uc002tca.2	+	2	642	c.500G>C	c.(499-501)GGC>GCC	p.G167A		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	167	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						GAGAACATTGGCACGATTTTC	0.493													C	103274233	C	C	103274233	3	2	145	1	0	0	0	0	1	0	0	0	14712	1203	42	5	506	5	SLC9A2	2	103274233	Missense_Mutation	SNP	G	TCGA-14-4157-01A-01D-1353-08	23189039	103274233	139925140	13	9945											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	145	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	105838879	209113112	34086261	14	9946											
GIGYF2	26058	broad.mit.edu	37	chr2	233613794	233613794	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctttacagaagaagaacaggTttgtgattagctctgagccc	10	8	1	5			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr2:233613794T>C	uc002vti.3	+	7	604	c.267_splice	c.e7+2	p.Q89_splice	GIGYF2_uc010zmj.1_Splice_Site_p.Q89_splice|GIGYF2_uc002vtg.2_Splice_Site_p.Q89_splice|GIGYF2_uc002vtj.3_Splice_Site_p.Q89_splice|GIGYF2_uc002vtk.3_Splice_Site_p.Q89_splice|GIGYF2_uc002vth.3_Splice_Site_p.Q89_splice|GIGYF2_uc010zmk.1_Splice_Site	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b						cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GAAGAACAGGTTTGTGATTAG	0.433													C	233613794	C	C	233613794	5	2	145	1	0	0	0	0	0	0	1	0	6378	1739	60	4	279	4	GIGYF2	2	233613794	Splice_Site	SNP	T	TCGA-14-4157-01A-01D-1353-08	24500682	233613794	9585579	15	9947											
PRKCD	5580	broad.mit.edu	37	chr3	53220653	53220653	+	Frame_Shift_Del	DEL	G	-	-													ttgtgatggagttcctcaacGggggggacctgatgtaccac							TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr3:53220653delG	uc003dgl.2	+	14	1647	c.1294delG	c.(1294-1296)GGGfs	p.G432fs	PRKCD_uc003dgm.2_Frame_Shift_Del_p.G432fs	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	432	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GTTCCTCAACGGGGGGGACCT	0.602													-	53220653	-	-	53220653	7	5	145	1	0	1	0	1	0	0	0	0	12509	1116	39	0	1340	0	PRKCD	3	53220653	Frame_Shift_Del	DEL	G	TCGA-14-4157-01A-01D-1353-08		53220653	144801777	16	9948											
RAP2B	5912	broad.mit.edu	37	chr3	152880606	152880606	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccatcgaagacttttaccgcAaggagattgaggtggactcg	12	9	0	3			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr3:152880606A>G	uc003ezr.2	+	1	578	c.124A>G	c.(124-126)AAG>GAG	p.K42E		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	42					Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			CTTTTACCGCAAGGAGATTGA	0.627													G	152880606	G	G	152880606	3	3	145	1	0	0	0	0	1	0	0	0	13041	131	5	4	126	4	RAP2B	3	152880606	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	99659953	152880606	45141824	17	9949											
MCCC1	56922	broad.mit.edu	37	chr3	182775185	182775185	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cacagcattgccatggtgatCaccaaacacctggacttcta	7	13	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr3:182775185C>G	uc003fle.2	-	8	924	c.787G>C	c.(787-789)GAT>CAT	p.D263H	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Missense_Mutation_p.D146H|MCCC1_uc003flg.2_Missense_Mutation_p.D154H|MCCC1_uc011bqp.1_Missense_Mutation_p.D216H|MCCC1_uc011bqq.1_Missense_Mutation_p.D154H	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	263	Biotin carboxylation.|ATP-grasp.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CCATGGTGATCACCAAACACC	0.413													G	182775185	G	G	182775185	3	3	145	1	0	0	0	0	1	0	0	0	9374	826	29	5	1438	5	MCCC1	3	182775185	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	29894579	182775185	15247245	18	9950											
ZNF595	152687	broad.mit.edu	37	chr4	59387	59387	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agagtggaaatgtctggaccCtgcccagcagaatttgtata	11	8	1	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr4:59387C>A	uc003fzv.1	+	2	224	c.68C>A	c.(67-69)CCT>CAT	p.P23H	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Missense_Mutation_p.T23N|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_Translation_Start_Site|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	23					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TGTCTGGACCCTGCCCAGCAG	0.423													A	59387	A	A	59387	3	1	145	1	0	0	0	0	1	0	0	0	18022	681	24	5	74	5	ZNF595	4	59387	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08		59387	191094889	19	9951											
MTHFD2L	441024	broad.mit.edu	37	chr4	75065528	75065528	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagaccacgttgatgagcgaAcaatatgcaatggaattgcc	10	9	0	3			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr4:75065528A>G	uc003hhn.1	+	7	813	c.295A>G	c.(295-297)ACA>GCA	p.T99A	MTHFD2L_uc011cbj.1_Missense_Mutation_p.T99A|MTHFD2L_uc011cbk.1_Missense_Mutation_p.T157A	NM_001144978	NP_001138450	Q9H903	MTD2L_HUMAN	methylenetetrahydrofolate dehydrogenase 2-like	99					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			ovary(1)|central_nervous_system(1)	2			all cancers(17;0.0101)|Lung(101;0.196)			TGATGAGCGAACAATATGCAA	0.313													G	75065528	G	G	75065528	3	3	145	1	0	0	0	0	1	0	0	0	9930	43	2	4	483	4	MTHFD2L	4	75065528	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	75006141	75065528	116088748	20	9952											
CDKN2AIP	55602	broad.mit.edu	37	chr4	184367366	184367366	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcagcaggaaaacagttcaAcgtgtatagggtcggccatc	11	10	2	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr4:184367366A>G	uc003ivp.1	+	3	691	c.529A>G	c.(529-531)ACG>GCG	p.T177A	CDKN2AIP_uc003ivq.1_5'UTR	NM_017632	NP_060102	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	177	Ser-rich.				negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		AAACAGTTCAACGTGTATAGG	0.473													G	184367366	G	G	184367366	3	3	145	1	0	0	0	0	1	0	0	0	3162	43	2	4	539	4	CDKN2AIP	4	184367366	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	109301838	184367366	6786910	21	9953											
TAF7	6879	broad.mit.edu	37	chr5	140698719	140698719	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gatcctcttgtcgttttgccCtgtcctgggtctcttggagc	11	12	2	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr5:140698719C>A	uc003ljg.2	-	1	1633	c.893G>T	c.(892-894)AGG>ATG	p.R298M		NM_005642	NP_005633	Q15545	TAF7_HUMAN	TATA box-binding protein-associated factor 2F	298	Potential.				negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTTTTGCCCTGTCCTGGGT	0.453													A	140698719	A	A	140698719	3	1	145	1	0	0	0	0	1	0	0	0	15529	681	24	5	160	5	TAF7	5	140698719	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08		140698719	40216541	22	9954											
CCNG1	900	broad.mit.edu	37	chr5	162868235	162868235	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agacttgatgagaatggaaaAgattgtattggagaaggtgt	14	1	0	5			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr5:162868235A>G	uc003lzb.2	+	4	550	c.416A>G	c.(415-417)AAG>AGG	p.K139R	CCNG1_uc011dek.1_Missense_Mutation_p.K3R|CCNG1_uc011del.1_Missense_Mutation_p.K3R|CCNG1_uc003lzc.2_RNA	NM_199246	NP_954854	P51959	CCNG1_HUMAN	cyclin G1	139					cell division|mitosis|regulation of cyclin-dependent protein kinase activity	nucleus				lung(1)|kidney(1)	2	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0597)|OV - Ovarian serous cystadenocarcinoma(192;0.107)|Epithelial(171;0.164)		AGAATGGAAAAGATTGTATTG	0.378													G	162868235	G	G	162868235	3	3	145	1	0	0	0	0	1	0	0	0	2923	72	3	4	422	4	CCNG1	5	162868235	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	22169516	162868235	18047025	23	9955											
OR2J3	442186	broad.mit.edu	37	chr6	29080438	29080438	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatctctctttttcattccGgccatgtgcatgtatctcca	6	12	4	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr6:29080438G>A	uc011dll.1	+	1	771	c.771G>A	c.(769-771)CCG>CCA	p.P257P		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTTCATTCCGGCCATGTGCA	0.458													A	29080438	A	A	29080438	2	1	145	1	0	0	0	0	0	0	0	1	11004	1103	39	2		2	OR2J3	6	29080438	Silent	SNP	G	TCGA-14-4157-01A-01D-1353-08		29080438	142034629	24	9956											
DNAH8	1769	broad.mit.edu	37	chr6	38783392	38783392	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagccccaccactactgacgTgacccatcaaaacacaggaa	6	16	1	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr6:38783392T>C	uc003ooe.1	+	24	3431	c.2831T>C	c.(2830-2832)GTG>GCG	p.V944A		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ACTACTGACGTGACCCATCAA	0.448													C	38783392	C	C	38783392	3	2	145	1	0	0	0	0	1	0	0	0	4607	1696	59	4	2917	4	DNAH8	6	38783392	Missense_Mutation	SNP	T	TCGA-14-4157-01A-01D-1353-08	9702954	38783392	132331675	25	9957											
CD2AP	23607	broad.mit.edu	37	chr6	47512403	47512403	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacaaaatgaggatgaactGgagctgaaagtgggagatat	13	5	0	4			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr6:47512403G>A	uc003oyw.2	+	4	837	c.381G>A	c.(379-381)CTG>CTA	p.L127L		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	127	SH3 2.|Interaction with ANLN and localization to the midbody.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AGGATGAACTGGAGCTGAAAG	0.313													A	47512403	A	A	47512403	2	1	145	1	0	0	0	0	0	0	0	1	2994	1335	47	3		3	CD2AP	6	47512403	Silent	SNP	G	TCGA-14-4157-01A-01D-1353-08	8729011	47512403	123602664	26	9958											
C6orf150	115004	broad.mit.edu	37	chr6	74149963	74149963	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tttccttcctttgcatgcttGggtacaaggtaaaatggctt	9	8	0	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr6:74149963G>T	uc003pgx.1	-	3	1222	c.1083C>A	c.(1081-1083)CCC>CCA	p.P361P		NM_138441	NP_612450	Q8N884	M21D1_HUMAN	hypothetical protein LOC115004	361											0						TTGCATGCTTGGGTACAAGGT	0.383													T	74149963	T	T	74149963	2	4	145	1	0	0	0	0	0	0	0	1	2337	1335	47	5		5	C6orf150	6	74149963	Silent	SNP	G	TCGA-14-4157-01A-01D-1353-08	26637560	74149963	96965104	27	9959											
LPA	4018	broad.mit.edu	37	chr6	160977190	160977190	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attaccatggtagcactgccGgaccacaggggtttgctcag	12	11	1	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr6:160977190G>A	uc003qtl.2	-	31	4960	c.4840C>T	c.(4840-4842)CGG>TGG	p.R1614W		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4122	Kringle 37.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity	p.R1614Q(1)		ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TAGCACTGCCGGACCACAGGG	0.463													A	160977190	A	A	160977190	3	1	145	1	0	0	0	0	1	0	0	0	8903	1115	39	2	1322	2	LPA	6	160977190	Missense_Mutation	SNP	G	TCGA-14-4157-01A-01D-1353-08	86827227	160977190	10137877	28	9960											
ZNF12	7559	broad.mit.edu	37	chr7	6737438	6737438	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacgtccttgaatgacactGgcccctgaaatggcaccgtg	10	14	0	3			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr7:6737438G>A	uc003sqt.1	-	3	574	c.20C>T	c.(19-21)CCA>CTA	p.P7L	ZNF12_uc011jxa.1_5'UTR|ZNF12_uc003sqs.1_Missense_Mutation_p.P7L	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	7					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		GAATGACACTGGCCCCTGAAA	0.493													A	6737438	A	A	6737438	3	1	145	1	0	0	0	0	1	0	0	0	17715	1348	47	3	2085	3	ZNF12	7	6737438	Missense_Mutation	SNP	G	TCGA-14-4157-01A-01D-1353-08		6737438	152401225	29	9961											
POM121C	100101267	broad.mit.edu	37	chr7	75070792	75070792	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catcctggagttgcgaggggAcagcacagccttcttgtgat	13	10	1	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr7:75070792A>T	uc010lde.1	-	2	709	c.709T>A	c.(709-711)TCC>ACC	p.S237T	POM121C_uc003udk.3_5'UTR|POM121C_uc003udl.1_RNA			A8CG34	P121C_HUMAN	Homo sapiens POM121-2 mRNA for nuclear pore membrane protein 121-2, partial cds.	237	Required for targeting to the nucleus and nuclear pore complex.|Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						TTGCGAGGGGACAGCACAGCC	0.527													T	75070792	T	T	75070792	3	4	145	1	0	0	0	0	1	0	0	0	12240	290	10	5		5	POM121C	7	75070792	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	68333354	75070792	84067871	30	9962											
TRRAP	8295	broad.mit.edu	37	chr7	98588209	98588209	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcacctgcctggttggctcGgagggaaagctgctcttgaa	13	11	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr7:98588209G>A	uc003upp.2	+	63	9944	c.9735G>A	c.(9733-9735)TCG>TCA	p.S3245S	TRRAP_uc011kis.1_Silent_p.S3216S|TRRAP_uc003upr.2_Silent_p.S2933S	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3245	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGTTGGCTCGGAGGGAAAGC	0.527													A	98588209	A	A	98588209	2	1	145	1	0	0	0	0	0	0	0	1	16598	1103	39	2		2	TRRAP	7	98588209	Silent	SNP	G	TCGA-14-4157-01A-01D-1353-08	23517417	98588209	60550454	31	9963											
RP1	6101	broad.mit.edu	37	chr8	55537403	55537403	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttctgaagatgatattgagAaatcaattatttttaatcaa	5	4	3	4			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr8:55537403A>G	uc003xsd.1	+	4	1109	c.961A>G	c.(961-963)AAA>GAA	p.K321E	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	321					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGATATTGAGAAATCAATTAT	0.323													G	55537403	G	G	55537403	3	3	145	1	0	0	0	0	1	0	0	0	13532	247	9	4	971	4	RP1	8	55537403	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08		55537403	90826619	32	9964											
ARHGAP39	80728	broad.mit.edu	37	chr8	145758601	145758601	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctggcgctcggggtagcGctctctctgcatgcccatga	13	14	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr8:145758601G>A	uc003zdt.1	-	9	3259	c.2704C>T	c.(2704-2706)CGC>TGC	p.R902C	ARHGAP39_uc011llk.1_Missense_Mutation_p.R902C|ARHGAP39_uc003zds.1_Missense_Mutation_p.R933C	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	902	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						TCGGGGTAGCGCTCTCTCTGC	0.647													A	145758601	A	A	145758601	3	1	145	1	0	0	0	0	1	0	0	0	884	1087	38	1	563	1	ARHGAP39	8	145758601	Missense_Mutation	SNP	G	TCGA-14-4157-01A-01D-1353-08	90221198	145758601	605421	33	9965											
C9orf21	195827	broad.mit.edu	37	chr9	99413984	99413984	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtccaatcactataagggtgAcatttgcttccttaggagaa	9	8	1	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr9:99413984A>G	uc004awm.2	-	3	308	c.272T>C	c.(271-273)GTC>GCC	p.V91A		NM_153698	NP_714542	Q7RTV5	CI021_HUMAN	hypothetical protein LOC195827	91							antioxidant activity|oxidoreductase activity			large_intestine(1)	1		Acute lymphoblastic leukemia(62;0.0559)				TATAAGGGTGACATTTGCTTC	0.313													G	99413984	G	G	99413984	3	3	145	1	0	0	0	0	1	0	0	0	2473	275	10	4	424	4	C9orf21	9	99413984	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08		99413984	41799447	34	9966											
OBP2A	29991	broad.mit.edu	37	chr9	138438640	138438640	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagatcacagggacctggtAcgtgaaggccatggtggtcg	15	10	1	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr9:138438640A>G	uc004cgb.2	+	2	131	c.89A>G	c.(88-90)TAC>TGC	p.Y30C	OBP2A_uc004cgc.2_Missense_Mutation_p.Y30C|OBP2A_uc010nau.2_RNA|OBP2A_uc010nav.2_Intron	NM_014582	NP_055397	Q9NY56	OBP2A_HUMAN	odorant binding protein 2A precursor	30					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		GGGACCTGGTACGTGAAGGCC	0.607													G	138438640	G	G	138438640	3	3	145	1	0	0	0	0	1	0	0	0	10810	391	14	4	95	4	OBP2A	9	138438640	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	39024656	138438640	2774791	35	9967											
NMT2	9397	broad.mit.edu	37	chr10	15183429	15183429	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagctctcactttcgaagGctgctgaattttaatctcct	7	11	2	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr10:15183429G>A	uc001inz.1	-	2	322	c.238C>T	c.(238-240)CCT>TCT	p.P80S	NMT2_uc001ioa.1_Silent_p.S52S|NMT2_uc009xjo.1_Missense_Mutation_p.P80S|NMT2_uc010qbz.1_5'UTR	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	80					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						ACTTTCGAAGGCTGCTGAATT	0.393													A	15183429	A	A	15183429	3	1	145	1	0	0	0	0	1	0	0	0	10504	1203	42	3	1302	3	NMT2	10	15183429	Missense_Mutation	SNP	G	TCGA-14-4157-01A-01D-1353-08		15183429	120351318	36	9968											
MYOZ1	58529	broad.mit.edu	37	chr10	75399754	75399754	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttcctcttcttattaggggCcggggttcctgagagcggca	13	10	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr10:75399754C>T	uc001jur.2	-	2	387	c.22G>A	c.(22-24)GCC>ACC	p.A8T		NM_021245	NP_067068	Q9NP98	MYOZ1_HUMAN	myozenin 1	8					myofibril assembly	nucleus|pseudopodium	FATZ binding			ovary(2)	2	Prostate(51;0.0112)					TTATTAGGGGCCGGGGTTCCT	0.542													T	75399754	T	T	75399754	3	4	145	1	0	0	0	0	1	0	0	0	10095	739	26	3	897	3	MYOZ1	10	75399754	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	60216325	75399754	60134993	37	9969											
EBF3	253738	broad.mit.edu	37	chr10	131676050	131676050	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acctggaatctccgcatatcTcgagggttgcctgcattctt	9	12	3	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr10:131676050T>C	uc001lki.1	-	7	677	c.618A>G	c.(616-618)CGA>CGG	p.R206R		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	206					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		TCCGCATATCTCGAGGGTTGC	0.368													C	131676050	C	C	131676050	2	2	145	1	0	0	0	0	0	0	0	1	4882	1538	54	4		4	EBF3	10	131676050	Silent	SNP	T	TCGA-14-4157-01A-01D-1353-08	56276296	131676050	3858697	38	9970											
TEAD1	7003	broad.mit.edu	37	chr11	12902599	12902599	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cagccaggatcctcacaagaGtaagtctgaggaggggtggg	16	8	2	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr11:12902599G>C	uc001mkj.3	+	7	1132	c.467_splice	c.e7+1	p.D156_splice	TEAD1_uc001mkk.3_Splice_Site_p.D75_splice|TEAD1_uc009ygl.2_Splice_Site_p.D50_splice	NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1						hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CCTCACAAGAGTAAGTCTGAG	0.547													C	12902599	C	C	12902599	5	2	145	1	0	0	0	0	0	0	1	0	15735	1043	36	5	531	5	TEAD1	11	12902599	Splice_Site	SNP	G	TCGA-14-4157-01A-01D-1353-08		12902599	122103917	39	9971											
OR4C15	81309	broad.mit.edu	37	chr11	55322827	55322827	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcaggaataaggaagtaaaaCaggccatgaggagaatatgg	13	4	1	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr11:55322827C>G	uc010rig.1	+	1	1045	c.1045C>G	c.(1045-1047)CAG>GAG	p.Q349E		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGAAGTAAAACAGGCCATGAG	0.328										HNSCC(20;0.049)			G	55322827	G	G	55322827	3	3	145	1	0	0	0	0	1	0	0	0	11048	479	17	5	1047	5	OR4C15	11	55322827	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	42420228	55322827	79683689	40	9972											
LRFN4	78999	broad.mit.edu	37	chr11	66626230	66626230	+	Frame_Shift_Del	DEL	G	-	-													ccaacgggaccttagagattGgggtgaccggcgctggggac							TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr11:66626230delG	uc001ojr.2	+	1	1355	c.1015delG	c.(1015-1017)GGGfs	p.G339fs	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojq.1_Frame_Shift_Del_p.G339fs|LRFN4_uc001ojs.2_Frame_Shift_Del_p.G339fs	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	339	Extracellular (Potential).|Ig-like.					integral to membrane					0						CTTAGAGATTGGGGTGACCGG	0.677													-	66626230	-	-	66626230	7	5	145	1	0	1	0	1	0	0	0	0	8940	1348	47	0	1017	0	LRFN4	11	66626230	Frame_Shift_Del	DEL	G	TCGA-14-4157-01A-01D-1353-08	11303403	66626230	68380286	41	9973											
KRT80	144501	broad.mit.edu	37	chr12	52565281	52565281	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcttctttcgggagggggcCttggagaggcctgatctgga	16	8	3	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr12:52565281C>T	uc001rzx.2	-	9	1358	c.1260G>A	c.(1258-1260)AAG>AAA	p.K420K	KRT80_uc001rzw.2_Silent_p.K455K|KRT80_uc001rzy.2_3'UTR	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	420	Tail.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		GGGAGGGGGCCTTGGAGAGGC	0.542													T	52565281	T	T	52565281	2	4	145	1	0	0	0	0	0	0	0	1	8494	680	24	3		3	KRT80	12	52565281	Silent	SNP	C	TCGA-14-4157-01A-01D-1353-08		52565281	81286614	42	9974											
LRIG3	121227	broad.mit.edu	37	chr12	59271381	59271381	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggatcacactgaggcgcacGtttcctctctcagtgccaag	11	13	3	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr12:59271381G>A	uc001sqr.2	-	15	2583	c.2337C>T	c.(2335-2337)AAC>AAT	p.N779N	LRIG3_uc009zqh.2_Silent_p.N719N|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	779	Ig-like C2-type 3.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			TGAGGCGCACGTTTCCTCTCT	0.532													A	59271381	A	A	59271381	2	1	145	1	0	0	0	0	0	0	0	1	8946	1136	40	1		1	LRIG3	12	59271381	Silent	SNP	G	TCGA-14-4157-01A-01D-1353-08	6706100	59271381	74580514	43	9975											
ANKLE2	23141	broad.mit.edu	37	chr12	133327271	133327272	+	Frame_Shift_Del	DEL	GA	-	-													gagtggagctgttttcacagGagacagtggtaaggacgttt							TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr12:133327271_133327272delGA	uc001ukx.2	-	3	871_872	c.804_805delTC	c.(802-807)TCTCCTfs	p.S268fs	ANKLE2_uc001uky.3_Frame_Shift_Del_p.S206fs	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	268_269						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		GTTTTCACAGGAGACAGTGGTA	0.426													-	133327272	-	-	133327271	7	5	145	1	0	1	0	1	0	0	0	0	633	1174	41	0	2055	0	ANKLE2	12	133327271	Frame_Shift_Del	DEL	GA	TCGA-14-4157-01A-01D-1353-08	74055890	133327271	524624	44	9976											
C14orf21	161424	broad.mit.edu	37	chr14	24769334	24769334	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gattcgcacccgcacctgagCccggaagctctgggatattt	11	13	1	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr14:24769334C>A	uc001wol.1	+	1	237	c.174C>A	c.(172-174)AGC>AGA	p.S58R	C14orf21_uc001wom.1_5'Flank|DHRS1_uc001woj.1_5'Flank|DHRS1_uc001wok.2_5'Flank	NM_174913	NP_777573	Q86U38	CN021_HUMAN	hypothetical protein LOC161424	58							RNA binding			breast(2)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(265;0.0185)		CGCACCTGAGCCCGGAAGCTC	0.662													A	24769334	A	A	24769334	3	1	145	1	0	0	0	0	1	0	0	0	1769	738	26	5	176	5	C14orf21	14	24769334	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08		24769334	82580206	45	9977											
C14orf101	54916	broad.mit.edu	37	chr14	57075891	57075891	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggtttgctgccctatgtccAccttcccatctcatcttacc	5	16	2	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr14:57075891A>G	uc001xcm.2	+	6	826	c.704A>G	c.(703-705)CAC>CGC	p.H235R	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xck.2_Missense_Mutation_p.H235R|C14orf101_uc010aot.1_Missense_Mutation_p.H235R|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_5'UTR	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	235	Helical; (Potential).					integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		CCCTATGTCCACCTTCCCATC	0.488													G	57075891	G	G	57075891	3	3	145	1	0	0	0	0	1	0	0	0	1734	159	6	4	726	4	C14orf101	14	57075891	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	32306557	57075891	50273649	46	9978											
PAPOLA	10914	broad.mit.edu	37	chr14	96986512	96986512	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtacttacacagaaactaatTgagacattgaaaccctttgg	7	8	0	3			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr14:96986512T>G	uc001yfq.2	+	2	339	c.129T>G	c.(127-129)ATT>ATG	p.I43M	PAPOLA_uc001yfo.2_Missense_Mutation_p.I43M|PAPOLA_uc001yfp.2_Missense_Mutation_p.I43M|PAPOLA_uc001yfr.2_Missense_Mutation_p.I43M|PAPOLA_uc010twv.1_Missense_Mutation_p.I43M|PAPOLA_uc010avp.2_Translation_Start_Site	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	43					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		AGAAACTAATTGAGACATTGA	0.408													G	96986512	G	G	96986512	3	3	145	1	0	0	0	0	1	0	0	0	11429	1800	63	5	135	5	PAPOLA	14	96986512	Missense_Mutation	SNP	T	TCGA-14-4157-01A-01D-1353-08	39910621	96986512	10363028	47	9979											
WARS	7453	broad.mit.edu	37	chr14	100808747	100808747	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctgctcaccttggttttgatCtgcttggccgtgtcggtgag	13	10	2	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr14:100808747C>A	uc001yhf.1	-	8	1185	c.1101G>T	c.(1099-1101)CAG>CAT	p.Q367H	WARS_uc001yhe.1_Missense_Mutation_p.Q173H|WARS_uc001yhg.1_Missense_Mutation_p.Q367H|WARS_uc001yhh.1_Missense_Mutation_p.Q367H|WARS_uc001yhi.1_Missense_Mutation_p.Q326H|WARS_uc001yhj.1_Missense_Mutation_p.Q326H|WARS_uc001yhk.1_Missense_Mutation_p.Q326H|WARS_uc001yhl.1_Missense_Mutation_p.Q367H	NM_173701	NP_776049	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase isoform a	367					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(1)	1		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	TGGTTTTGATCTGCTTGGCCG	0.622													A	100808747	A	A	100808747	3	1	145	1	0	0	0	0	1	0	0	0	17246	912	32	5	326	5	WARS	14	100808747	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	3822235	100808747	6540793	48	9980											
SPTBN5	51332	broad.mit.edu	37	chr15	42185109	42185109	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccttggccctgaggaaggCcagagctcggctgctgttct	13	13	1	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr15:42185109C>T	uc001zos.2	-	3	595	c.262G>A	c.(262-264)GCC>ACC	p.A88T	uc010bcp.1_RNA	NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	123	Actin-binding.|CH 1.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CTGAGGAAGGCCAGAGCTCGG	0.687													T	42185109	T	T	42185109	3	4	145	1	0	0	0	0	1	0	0	0	15121	739	26	3	10921	3	SPTBN5	15	42185109	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08		42185109	60346283	49	9981											
PDIA3	2923	broad.mit.edu	37	chr15	44055362	44055362	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taactaccgatttgcacataCgaatgttgagtctctggtga	9	8	1	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr15:44055362C>T	uc001zsu.2	+	5	708	c.560C>T	c.(559-561)ACG>ATG	p.T187M	PDIA3_uc010bdp.2_Missense_Mutation_p.T167M|PDIA3_uc010ued.1_Translation_Start_Site	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	187					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		TTTGCACATACGAATGTTGAG	0.408													T	44055362	T	T	44055362	3	4	145	1	0	0	0	0	1	0	0	0	11669	536	19	1	578	1	PDIA3	15	44055362	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	1870253	44055362	58476030	50	9982											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84442304	84442304	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacactcgttcagatgaagaCaaagatggcaactgggatgc	11	8	1	4			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr15:84442304C>T	uc002bjz.3	+	4	443	c.219C>T	c.(217-219)GAC>GAT	p.D73D	ADAMTSL3_uc002bjy.1_Silent_p.D73D|ADAMTSL3_uc010bmt.1_Silent_p.D73D|ADAMTSL3_uc010bmu.1_Silent_p.D73D	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	73						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CAGATGAAGACAAAGATGGCA	0.438													T	84442304	T	T	84442304	2	4	145	1	0	0	0	0	0	0	0	1	276	477	17	3		3	ADAMTSL3	15	84442304	Silent	SNP	C	TCGA-14-4157-01A-01D-1353-08	40386942	84442304	18089088	51	9983											
ZFHX3	463	broad.mit.edu	37	chr16	72831003	72831003	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcagagtgactctgggctaTagagagttggttctgctgct	15	7	2	3			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr16:72831003T>C	uc002fck.2	-	9	6251	c.5578A>G	c.(5578-5580)ATA>GTA	p.I1860V	ZFHX3_uc002fcl.2_Missense_Mutation_p.I946V	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1860					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CTCTGGGCTATAGAGAGTTGG	0.532													C	72831003	C	C	72831003	3	2	145	1	0	0	0	0	1	0	0	0	17631	1406	49	4	5541	4	ZFHX3	16	72831003	Missense_Mutation	SNP	T	TCGA-14-4157-01A-01D-1353-08		72831003	17523750	52	9984											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	13	14	3	0	rs28934578		TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578406	T	T	7578406	3	4	145	1	0	0	0	0	1	0	0	0	16378	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08		7578406	73616804	53	9985											
TP53	7157	broad.mit.edu	37	chr17	7578460	7578460	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtagatggccatggcgcggAcgcgggtgccgggcgggggt	22	9	0	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr17:7578460A>C	uc002gim.2	-	5	664	c.470T>G	c.(469-471)GTC>GGC	p.V157G	TP53_uc002gig.1_Missense_Mutation_p.V157G|TP53_uc002gih.2_Missense_Mutation_p.V157G|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V25G|TP53_uc010cng.1_Missense_Mutation_p.V25G|TP53_uc002gii.1_Missense_Mutation_p.V25G|TP53_uc010cnh.1_Missense_Mutation_p.V157G|TP53_uc010cni.1_Missense_Mutation_p.V157G|TP53_uc002gij.2_Missense_Mutation_p.V157G|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V64G|TP53_uc002gio.2_Missense_Mutation_p.V25G|TP53_uc010vug.1_Missense_Mutation_p.V118G	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	157	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> I (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> F (in sporadic cancers; somatic mutation).|V -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(139)|p.V157I(10)|p.V157D(8)|p.V157G(7)|p.0?(7)|p.V157L(6)|p.V157V(5)|p.V157fs*13(3)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.V157A(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.D148fs*23(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.V157fs*25(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGGCGCGGACGCGGGTGCC	0.617		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578460	C	C	7578460	3	2	145	1	0	0	0	0	1	0	0	0	16378	275	10	5	828	5	TP53	17	7578460	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	54	7578460	73616750	54	9986											
ZNF207	7756	broad.mit.edu	37	chr17	30696410	30696410	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagttggaccaattggaggtAtgatgccaccacagccaggc	12	11	0	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr17:30696410A>G	uc002hhh.3	+	10	1361	c.1213A>G	c.(1213-1215)ATG>GTG	p.M405V	ZNF207_uc002hhj.3_Missense_Mutation_p.M421V|ZNF207_uc002hhi.3_Missense_Mutation_p.M390V|ZNF207_uc010csz.2_Missense_Mutation_p.M424V|ZNF207_uc002hhk.1_Missense_Mutation_p.M421V|ZNF207_uc002hhl.1_RNA	NM_003457	NP_003448	O43670	ZN207_HUMAN	zinc finger protein 207 isoform a	405						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			AATTGGAGGTATGATGCCACC	0.488													G	30696410	G	G	30696410	3	3	145	1	0	0	0	0	1	0	0	0	17762	449	16	4	1303	4	ZNF207	17	30696410	Missense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	23117950	30696410	50498800	55	9987											
TAF15	8148	broad.mit.edu	37	chr17	34171636	34171636	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggagatagaagtgggggcGgctatggtggagacagaagt	20	4	0	4			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr17:34171636G>A	uc002hkd.2	+	15	1419	c.1333G>A	c.(1333-1335)GGC>AGC	p.G445S	TAF15_uc002hkc.2_Missense_Mutation_p.G442S	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	445	Arg/Gly-rich.|5.|21 X approximate tandem repeats of D-R- [S,G](0,3)-G-G-Y-G-G.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		aagtgggggcggctatggtgg	0			T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								A	34171636	A	A	34171636	3	1	145	1	0	0	0	0	1	0	0	0	15515	1116	39	2	1391	2	TAF15	17	34171636	Missense_Mutation	SNP	G	TCGA-14-4157-01A-01D-1353-08	3475226	34171636	47023574	56	9988											
NR1D1	9572	broad.mit.edu	37	chr17	38253028	38253028	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cacagtaacaccatgccattCagctctgtggaagagacggg	11	11	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr17:38253028C>G	uc002htz.1	-	3	1001	c.375G>C	c.(373-375)CTG>CTC	p.L125L	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_5'UTR	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	125					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					CCATGCCATTCAGCTCTGTGG	0.622													G	38253028	G	G	38253028	2	3	145	1	0	0	0	0	0	0	0	1	10615	813	29	5		5	NR1D1	17	38253028	Silent	SNP	C	TCGA-14-4157-01A-01D-1353-08	4081392	38253028	42942182	57	9989											
FBF1	85302	broad.mit.edu	37	chr17	73922854	73922854	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctaccttgatctctcactgTgctggggctcttgtcagaag	10	12	4	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr17:73922854T>C	uc002jqc.2	-	9	812	c.538A>G	c.(538-540)ACA>GCA	p.T180A	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.T170A|FBF1_uc002jqd.1_Missense_Mutation_p.T180A	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	180											0						TCTCTCACTGTGCTGGGGCTC	0.512													C	73922854	C	C	73922854	3	2	145	1	0	0	0	0	1	0	0	0	5695	1696	59	4	2947	4	FBF1	17	73922854	Missense_Mutation	SNP	T	TCGA-14-4157-01A-01D-1353-08	35669826	73922854	7272356	58	9990											
OR10H2	26538	broad.mit.edu	37	chr19	15839024	15839024	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgagcgcagcctccacacGcccatgtacctcttcctgtg	9	17	1	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr19:15839024G>A	uc002nbm.2	+	1	191	c.171G>A	c.(169-171)ACG>ACA	p.T57T		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GCCTCCACACGCCCATGTACC	0.612													A	15839024	A	A	15839024	2	1	145	1	0	0	0	0	0	0	0	1	10906	1074	38	1		1	OR10H2	19	15839024	Silent	SNP	G	TCGA-14-4157-01A-01D-1353-08		15839024	43289959	59	9991											
LRP3	4037	broad.mit.edu	37	chr19	33697915	33697915	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctctgtgctgcagaatcttCgcacagccatgcggagacag	11	13	2	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr19:33697915C>T	uc010edh.2	+	7	1840	c.1747C>T	c.(1747-1749)CGC>TGC	p.R583C	LRP3_uc002nuk.3_Missense_Mutation_p.R457C	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	583	Cytoplasmic (Potential).				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)					GCAGAATCTTCGCACAGCCAT	0.552													T	33697915	T	T	33697915	3	4	145	1	0	0	0	0	1	0	0	0	8958	884	31	2	1773	2	LRP3	19	33697915	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	17858891	33697915	25431068	60	9992											
FFAR2	2867	broad.mit.edu	37	chr19	35940825	35940825	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcaagatcatcgaggctgCgtcgaacttccgctggtacc	10	13	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr19:35940825C>T	uc002nzg.2	+	2	289	c.209C>T	c.(208-210)GCG>GTG	p.A70V	FFAR2_uc010eea.2_Missense_Mutation_p.A70V	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	70	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			ATCGAGGCTGCGTCGAACTTC	0.637													T	35940825	T	T	35940825	3	4	145	1	0	0	0	0	1	0	0	0	5828	768	27	1	211	1	FFAR2	19	35940825	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	2242910	35940825	23188158	61	9993											
ZNF283	284349	broad.mit.edu	37	chr19	44351487	44351487	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agaatgtgggaagaattattTaagtgcctatcaactcaatg	9	5	2	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr19:44351487T>A	uc002oxr.3	+	7	1002	c.734T>A	c.(733-735)TTA>TAA	p.L245*	ZNF283_uc002oxp.3_Nonsense_Mutation_p.L106*	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	245	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				AAGAATTATTTAAGTGCCTAT	0.408													A	44351487	A	A	44351487	4	1	145	1	0	0	0	0	0	1	0	0	17817	1764	61	5	748	5	ZNF283	19	44351487	Nonsense_Mutation	SNP	T	TCGA-14-4157-01A-01D-1353-08	8410662	44351487	14777496	62	9994											
SAE1	10055	broad.mit.edu	37	chr19	47700626	47700626	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctgacctgcttcctgaggaCtttgtcaggttggtgtcagt	12	10	2	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr19:47700626C>A	uc002pgc.2	+	7	926	c.870C>A	c.(868-870)GAC>GAA	p.D290E	SAE1_uc002pgd.2_Intron|SAE1_uc010ekx.2_Intron|SAE1_uc010ekw.2_RNA|SAE1_uc010xyk.1_Missense_Mutation_p.D116E|SAE1_uc002pge.2_Missense_Mutation_p.D226E	NM_016402	NP_057486	Q9UBE0	SAE1_HUMAN	SubName: Full=SUMO-1 activating enzyme subunit 1, isoform CRA_b; SubName: Full=cDNA, FLJ96708, Homo sapiens SUMO-1 activating enzyme subunit 1 (SAE1), mRNA;	290					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			ovary(1)	1		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		TTCCTGAGGACTTTGTCAGGT	0.398													A	47700626	A	A	47700626	3	1	145	1	0	0	0	0	1	0	0	0	13805	564	20	5	896	5	SAE1	19	47700626	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	3349139	47700626	11428357	63	9995											
PRIC285	85441	broad.mit.edu	37	chr20	62200951	62200951	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagccggcctggcgggaggCcgggagccaccagagagaag	19	11	0	3			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr20:62200951C>T	uc002yfm.2	-	5	1530	c.638G>A	c.(637-639)GGC>GAC	p.G213D	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	213					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TGGCGGGAGGCCGGGAGCCAC	0.697													T	62200951	T	T	62200951	3	4	145	1	0	0	0	0	1	0	0	0	12485	739	26	3	7398	3	PRIC285	20	62200951	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08		62200951	824569	64	9996											
UCKL1	54963	broad.mit.edu	37	chr20	62577191	62577191	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cggctgtgcgtggtgaagtcAtaaatgggcaccttgacact	13	9	1	2			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr20:62577191A>T	uc010gkn.2	-	4	592	c.549T>A	c.(547-549)TAT>TAA	p.Y183*	UCKL1_uc011abm.1_Nonsense_Mutation_p.Y168*|UCKL1_uc011abn.1_RNA|UCKL1_uc011abo.1_RNA	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	183					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TGGTGAAGTCATAAATGGGCA	0.587													T	62577191	T	T	62577191	4	4	145	1	0	0	0	0	0	1	0	0	16922	224	8	5	1145	5	UCKL1	20	62577191	Nonsense_Mutation	SNP	A	TCGA-14-4157-01A-01D-1353-08	376240	62577191	448329	65	9997											
PRPF6	24148	broad.mit.edu	37	chr20	62648082	62648082	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgttcctctttcaggatgccGaggaatgtgacagggctggg	15	8	2	1			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr20:62648082G>A	uc002yho.2	+	12	1699	c.1531G>A	c.(1531-1533)GAG>AAG	p.E511K	PRPF6_uc002yhp.2_Missense_Mutation_p.E511K	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	511					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TCAGGATGCCGAGGAATGTGA	0.512													A	62648082	A	A	62648082	3	1	145	1	0	0	0	0	1	0	0	0	12574	1059	37	2	1577	2	PRPF6	20	62648082	Missense_Mutation	SNP	G	TCGA-14-4157-01A-01D-1353-08	70891	62648082	377438	66	9998											
MKL1	57591	broad.mit.edu	37	chr22	40814732	40814737	+	In_Frame_Del	DEL	GGGGGC	-	-													tgcttcacgggggtgccgagGggggcgggggcgggggcggg					rs144888766	by1000genomes	TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chr22:40814732_40814737delGGGGGC	uc003ayv.1	-	9	1912_1917	c.1705_1710delGCCCCC	c.(1705-1710)GCCCCCdel	p.AP569del	MKL1_uc003ayw.1_In_Frame_Del_p.AP569del|MKL1_uc010gye.1_In_Frame_Del_p.AP569del|MKL1_uc010gyf.1_In_Frame_Del_p.AP519del	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	569_570	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGGTGCCGAGgggggcgggggcgggg	0.621			T	RBM15	acute megakaryocytic leukemia								-	40814737	-	-	40814732	7	5	145	1	0	1	0	1	0	0	0	0	9601	1219	43	0	1101	0	MKL1	22	40814732	In_Frame_Del	DEL	GGGGGC	TCGA-14-4157-01A-01D-1353-08		40814732	10489834	67	9999											
KIAA2022	340533	broad.mit.edu	37	chrX	73959989	73959989	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtggacctgttctcgcTccatgtgctttcccttacat	7	14	1	0			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chrX:73959989T>C	uc004eby.2	-	3	5020	c.4403A>G	c.(4402-4404)GAG>GGG	p.E1468G		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1468					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity	p.E1468G(1)		ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTGTTCTCGCTCCATGTGCTT	0.473													C	73959989	C	C	73959989	3	2	145	1	0	0	0	0	1	0	0	0	8269	1551	54	4	155	4	KIAA2022	23	73959989	Missense_Mutation	SNP	T	TCGA-14-4157-01A-01D-1353-08		73959989	81310571	68	10000											
ATRX	546	broad.mit.edu	37	chrX	76937111	76937111	+	Frame_Shift_Del	DEL	G	-	-													tccctcacctatagaattctGatcatcatcttctatatcag							TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chrX:76937111delG	uc004ecp.3	-	9	3869	c.3637delC	c.(3637-3639)CAGfs	p.Q1213fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.Q1175fs|ATRX_uc004eco.3_Frame_Shift_Del_p.Q998fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.Q1145fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.Q1184fs|ATRX_uc010nly.1_Frame_Shift_Del_p.Q1158fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1213					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ATAGAATTCTGATCATCATCT	0.388			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						-	76937111	-	-	76937111	7	5	145	1	0	1	0	1	0	0	0	0	1208	1299	45	0	3949	0	ATRX	23	76937111	Frame_Shift_Del	DEL	G	TCGA-14-4157-01A-01D-1353-08	2977122	76937111	78333449	69	10001											
DIAPH2	1730	broad.mit.edu	37	chrX	96638984	96638984	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaacttgcaaaagagaaagCtgaacaagaaaagttagaac	8	5	0	4			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chrX:96638984C>T	uc004efu.3	+	25	3482	c.3086C>T	c.(3085-3087)GCT>GTT	p.A1029V	DIAPH2_uc004eft.3_Missense_Mutation_p.A1029V	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	1029	Potential.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						AAAGAGAAAGCTGAACAAGAA	0.313													T	96638984	T	T	96638984	3	4	145	1	0	0	0	0	1	0	0	0	4519	797	28	3	3184	3	DIAPH2	23	96638984	Missense_Mutation	SNP	C	TCGA-14-4157-01A-01D-1353-08	19701873	96638984	58631576	70	10002											
VAMP7	6845	broad.mit.edu	37	chrX	155149532	155149532	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgattgacaaaacagaaaaTcttgtggattctgtaagtat	8	4	2	3			TCGA-14-4157-01A-01D-1353-08	TCGA-14-4157-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c38bd53-aad2-46aa-8c37-356aa27003ee	406bcb85-4374-4dad-86b7-1776aeb412cd	g.chrX:155149532T>G	uc004fnr.2	+	6	663	c.489T>G	c.(487-489)AAT>AAG	p.N163K	VAMP7_uc004fnt.2_Missense_Mutation_p.N122K|VAMP7_uc011naa.1_Missense_Mutation_p.N124K|VAMP7_uc011nab.1_Missense_Mutation_p.N62K|VAMP7_uc004fns.2_Intron|VAMP7_uc011nac.1_Missense_Mutation_p.N96K	NM_005638	NP_005629	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7 isoform 1	163	v-SNARE coiled-coil homology.|Cytoplasmic (Potential).				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AAACAGAAAATCTTGTGGATT	0.338													G	155149532	G	G	155149532	3	3	145	1	0	0	0	0	1	0	0	0	17114	1432	50	5	507	5	VAMP7	23	155149532	Missense_Mutation	SNP	T	TCGA-14-4157-01A-01D-1353-08	58510548	155149532	121028	71	10003											
KIAA1751	85452	broad.mit.edu	37	chr1	1888142	1888142	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcgtgcccaagcccccaaCgttggtcagcgtgatggtcc	12	14	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr1:1888142C>T	uc001aim.1	-	17	2089	c.1933G>A	c.(1933-1935)GTT>ATT	p.V645I	KIAA1751_uc009vkz.1_Missense_Mutation_p.V645I	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	645										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		AAGCCCCCAACGTTGGTCAGC	0.572													T	1888142	T	T	1888142	3	4	146	1	0	0	0	0	1	0	0	0	8256	536	19	1	363	1	KIAA1751	1	1888142	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08		1888142	247362479	1	10004											
KIF1B	23095	broad.mit.edu	37	chr1	10425498	10425498	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgccactttttgctgctgcGtgagagacttggtgacagca	12	11	0	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr1:10425498G>A	uc001aqx.3	+	43	4746	c.4544G>A	c.(4543-4545)CGT>CAT	p.R1515H	KIF1B_uc001aqw.3_Missense_Mutation_p.R1469H|KIF1B_uc001aqy.2_Missense_Mutation_p.R1489H|KIF1B_uc001aqz.2_Missense_Mutation_p.R1515H|KIF1B_uc001ara.2_Missense_Mutation_p.R1475H|KIF1B_uc001arb.2_Missense_Mutation_p.R1501H	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	1515					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TTGCTGCTGCGTGAGAGACTT	0.507													A	10425498	A	A	10425498	3	1	146	1	0	0	0	0	1	0	0	0	8284	1145	40	1	6053	1	KIF1B	1	10425498	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	8537356	10425498	238825123	2	10005											
RPL11	6135	broad.mit.edu	37	chr1	24019182	24019185	+	Frame_Shift_Del	DEL	AGAC	-	-													atctgtgttggggagagtggAgacagactgacgcgagcagc							TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr1:24019182_24019185delAGAC	uc001bhk.2	+	2	110_113	c.90_93delAGAC	c.(88-93)GGAGACfs	p.G30fs	RPL11_uc001bhl.2_Frame_Shift_Del_p.G29fs|RPL11_uc001bhm.2_Frame_Shift_Del_p.G19fs|RPL11_uc001bhn.1_Frame_Shift_Del_p.G19fs	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11	30_31				D -> G (in Ref. 1; CAA55816).	endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		GGGAGAGTGGAGACAGACTGACGC	0.544													-	24019185	-	-	24019182	7	5	146	1	0	1	0	1	0	0	0	0	13557	291	11	0	96	0	RPL11	1	24019182	Frame_Shift_Del	DEL	AGAC	TCGA-15-0742-01A-01W-0348-08	13593684	24019182	225231439	3	10006											
CNKSR1	10256	broad.mit.edu	37	chr1	26507077	26507077	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccaggagctcatcctgggCggggtggaacagctccaggc	15	13	1	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr1:26507077C>T	uc001bln.3	+	2	244	c.186C>T	c.(184-186)GGC>GGT	p.G62G	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Silent_p.G62G|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	62	SAM.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TCATCCTGGGCGGGGTGGAAC	0.657													T	26507077	T	T	26507077	2	4	146	1	0	0	0	0	0	0	0	1	3606	755	27	1		1	CNKSR1	1	26507077	Silent	SNP	C	TCGA-15-0742-01A-01W-0348-08	2487895	26507077	222743544	4	10007											
TACSTD2	4070	broad.mit.edu	37	chr1	59042498	59042498	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcgcgccttgaagcggccctCggggtcgcagtcggggtcgt	18	13	0	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr1:59042498C>T	uc001cyz.3	-	1	669	c.331G>A	c.(331-333)GAG>AAG	p.E111K		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	111	Extracellular (Potential).|Thyroglobulin type-1.				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					AAGCGGCCCTCGGGGTCGCAG	0.706													T	59042498	T	T	59042498	3	4	146	1	0	0	0	0	1	0	0	0	15505	893	31	2	644	2	TACSTD2	1	59042498	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	32535421	59042498	190208123	5	10008											
CCDC18	343099	broad.mit.edu	37	chr1	93698049	93698049	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagagacttctgagcaaaacGttattctacagcatactctt	6	9	3	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr1:93698049G>A	uc001dpq.2	+	18	2881	c.2713G>A	c.(2713-2715)GTT>ATT	p.V905I	CCDC18_uc009wdl.1_Missense_Mutation_p.V422I	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	786	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TGAGCAAAACGTTATTCTACA	0.318													A	93698049	A	A	93698049	3	1	146	1	0	0	0	0	1	0	0	0	2794	1145	40	1	2783	1	CCDC18	1	93698049	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	34655551	93698049	155552572	6	10009											
NOTCH2	4853	broad.mit.edu	37	chr1	120510196	120510196	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacactcacagtggaaggcgCcatccgtgttcacacatttt	9	12	2	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr1:120510196C>T	uc001eik.2	-	8	1569	c.1313G>A	c.(1312-1314)GGC>GAC	p.G438D	NOTCH2_uc001eil.2_Missense_Mutation_p.G438D|NOTCH2_uc001eim.3_Missense_Mutation_p.G355D	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	438	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGGAAGGCGCCATCCGTGTT	0.478			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				T	120510196	T	T	120510196	3	4	146	1	0	0	0	0	1	0	0	0	10548	739	26	3	6210	3	NOTCH2	1	120510196	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	26812147	120510196	128740425	7	10010											
LOXL3	84695	broad.mit.edu	37	chr2	74779634	74779634	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaagccagccagccggaacCgaagcccctggctcccggcc	13	18	0	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr2:74779634C>T	uc002smp.1	-	2	200	c.128G>A	c.(127-129)CGG>CAG	p.R43Q	LOXL3_uc002smo.1_5'Flank|LOXL3_uc010ffm.1_Missense_Mutation_p.R43Q|LOXL3_uc002smq.1_Missense_Mutation_p.R43Q|LOXL3_uc010ffn.1_Missense_Mutation_p.R43Q|DOK1_uc002smr.2_Intron|DOK1_uc002sms.2_5'Flank|DOK1_uc010ffo.2_5'Flank|DOK1_uc002smt.2_5'Flank|DOK1_uc002smu.2_5'Flank|DOK1_uc010yrz.1_5'Flank|DOK1_uc002smv.2_5'Flank|DOK1_uc002smw.1_5'Flank	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	43						extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CAGCCGGAACCGAAGCCCCTG	0.662													T	74779634	T	T	74779634	3	4	146	1	0	0	0	0	1	0	0	0	8901	652	23	2	2185	2	LOXL3	2	74779634	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08		74779634	168419739	8	10011											
LONRF2	164832	broad.mit.edu	37	chr2	100916305	100916305	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	taacgcctttttatcctcttCaaagtgtagacccagtataa	5	10	2	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr2:100916305C>A	uc002tal.3	-	5	1781	c.1141G>T	c.(1141-1143)GAA>TAA	p.E381*	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	381					proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						TTATCCTCTTCAAAGTGTAGA	0.413													A	100916305	A	A	100916305	4	1	146	1	0	0	0	0	0	1	0	0	8895	835	29	5	1155	5	LONRF2	2	100916305	Nonsense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	26136671	100916305	142283068	9	10012											
SLC20A1	6574	broad.mit.edu	37	chr2	113417335	113417335	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgcccatggtggcaatgacGtaaggtcagttgacattgat	12	8	1	3	rs142437239		TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr2:113417335G>A	uc002tib.2	+	8	2049	c.1603G>A	c.(1603-1605)GTA>ATA	p.V535I	SLC20A1_uc002tic.1_Missense_Mutation_p.V347I	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	535	Extracellular (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						TGGCAATGACGTAAGGTCAGT	0.458													A	113417335	A	A	113417335	3	1	146	1	0	0	0	0	1	0	0	0	14438	1145	40	1	1629	1	SLC20A1	2	113417335	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	12501030	113417335	129782038	10	10013											
LRP1B	53353	broad.mit.edu	37	chr2	141072536	141072536	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtacgcaagttcctccattcTggcagtagttgctacagtgg	11	10	1	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr2:141072536T>C	uc002tvj.1	-	83	13745	c.12773A>G	c.(12772-12774)CAG>CGG	p.Q4258R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4258	Extracellular (Potential).|EGF-like 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCTCCATTCTGGCAGTAGTT	0.373										TSP Lung(27;0.18)			C	141072536	C	C	141072536	3	2	146	1	0	0	0	0	1	0	0	0	8955	1580	55	4	1062	4	LRP1B	2	141072536	Missense_Mutation	SNP	T	TCGA-15-0742-01A-01W-0348-08	27655201	141072536	102126837	11	10014											
LRP1B	53353	broad.mit.edu	37	chr2	141072633	141072633	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttctcatttaaaatgcatcTtcctccattttcacaagtta	2	10	3	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr2:141072633T>C	uc002tvj.1	-	83	13648	c.12676A>G	c.(12676-12678)AGA>GGA	p.R4226G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4226	Extracellular (Potential).|EGF-like 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAAATGCATCTTCCTCCATTT	0.343										TSP Lung(27;0.18)			C	141072633	C	C	141072633	3	2	146	1	0	0	0	0	1	0	0	0	8955	1617	56	4	1159	4	LRP1B	2	141072633	Missense_Mutation	SNP	T	TCGA-15-0742-01A-01W-0348-08	97	141072633	102126740	12	10015											
LRP1B	53353	broad.mit.edu	37	chr2	141092130	141092130	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aacagtccagtacatcatccTgaagagagcgggtcagagag	12	9	2	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr2:141092130T>C	uc002tvj.1	-	79	13089	c.12117_splice	c.e79-1	p.G4039_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TACATCATCCTGAAGAGAGCG	0.358										TSP Lung(27;0.18)			C	141092130	C	C	141092130	5	2	146	1	0	0	0	0	0	0	1	0	8955	1594	55	4	1736	4	LRP1B	2	141092130	Splice_Site	SNP	T	TCGA-15-0742-01A-01W-0348-08	19497	141092130	102107243	13	10016											
CHL1	10752	broad.mit.edu	37	chr3	439999	439999	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgggagctgaacatatagttCgcctaatgactaagaattgg	11	7	0	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr3:439999C>T	uc003bou.2	+	24	3407	c.3136C>T	c.(3136-3138)CGC>TGC	p.R1046C	CHL1_uc003bot.2_Missense_Mutation_p.R1062C|CHL1_uc003bow.1_Missense_Mutation_p.R1046C|CHL1_uc011asi.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1046	Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		ACATATAGTTCGCCTAATGAC	0.388													T	439999	T	T	439999	3	4	146	1	0	0	0	0	1	0	0	0	3349	884	31	2	3274	2	CHL1	3	439999	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08		439999	197582431	14	10017											
NEK10	152110	broad.mit.edu	37	chr3	27233555	27233555	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctcatggtgacatgtgaCggtgttccggttggcttcca	13	10	1	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr3:27233555C>T	uc010hfk.2	-	5	635	c.406G>A	c.(406-408)GTC>ATC	p.V136I	NEK10_uc003cds.1_Missense_Mutation_p.V221I|NEK10_uc010hfj.2_Missense_Mutation_p.V136I			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	824							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TGACATGTGACGGTGTTCCGG	0.438													T	27233555	T	T	27233555	3	4	146	1	0	0	0	0	1	0	0	0	10322	551	19	1		1	NEK10	3	27233555	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	26793556	27233555	170788875	15	10018											
SCN11A	11280	broad.mit.edu	37	chr3	38951639	38951639	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccaaagttgtcaaaattcGtataattatagtcaggatta	7	5	2	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr3:38951639G>A	uc011ays.1	-	8	1218	c.1019C>T	c.(1018-1020)ACG>ATG	p.T340M		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	340	I.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.T340T(1)		skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GTCAAAATTCGTATAATTATA	0.358													A	38951639	A	A	38951639	3	1	146	1	0	0	0	0	1	0	0	0	13913	1145	40	1	4432	1	SCN11A	3	38951639	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	11718084	38951639	159070791	16	10019											
PLSCR1	5359	broad.mit.edu	37	chr3	146239654	146239654	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggacaacaacagctgctaCatcttagtggtctctccaga	9	11	2	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr3:146239654C>T	uc003evx.3	-	6	930	c.542G>A	c.(541-543)TGT>TAT	p.C181Y	PLSCR1_uc003evy.3_Missense_Mutation_p.C174Y|PLSCR1_uc011bnn.1_Missense_Mutation_p.C100Y|PLSCR1_uc003evz.3_Intron	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	181	Cytoplasmic.|Cys-rich.				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						ACAGCTGCTACATCTTAGTGG	0.438													T	146239654	T	T	146239654	3	4	146	1	0	0	0	0	1	0	0	0	12109	478	17	3	430	3	PLSCR1	3	146239654	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	107288015	146239654	51782776	17	10020											
SI	6476	broad.mit.edu	37	chr3	164700076	164700076	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaagcgaatttttatttccGttatacgttagagtaactgc	9	6	0	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr3:164700076G>A	uc003fei.2	-	47	5432	c.5370C>T	c.(5368-5370)AAC>AAT	p.N1790N		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1790	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTTTATTTCCGTTATACGTTA	0.348										HNSCC(35;0.089)			A	164700076	A	A	164700076	2	1	146	1	0	0	0	0	0	0	0	1	14297	1136	40	1		1	SI	3	164700076	Silent	SNP	G	TCGA-15-0742-01A-01W-0348-08	18460422	164700076	33322354	18	10021											
PIK3CA	5290	broad.mit.edu	37	chr3	178916851	178916853	+	In_Frame_Del	DEL	GAA	-	-													ttactcaagaagcagaaaggGaagaattttttgatgaaaca							TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr3:178916851_178916853delGAA	uc003fjk.2	+	2	395_397	c.238_240delGAA	c.(238-240)GAAdel	p.E81del		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	81	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E81K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGCAGAAAGGGAAGAATTTTTTG	0.365		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			-	178916853	-	-	178916851	7	5	146	1	0	1	0	1	0	0	0	0	11913	1175	41	0	240	0	PIK3CA	3	178916851	In_Frame_Del	DEL	GAA	TCGA-15-0742-01A-01W-0348-08	14216775	178916851	19105579	19	10022											
TMEM207	131920	broad.mit.edu	37	chr3	190147491	190147491	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttgagtttgaaggtgaattcCaacagttggactcacagctg	11	7	1	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr3:190147491C>G	uc003fsj.2	-	5	401	c.334G>C	c.(334-336)GGA>CGA	p.G112R		NM_207316	NP_997199	Q6UWW9	TM207_HUMAN	transmembrane protein 207 precursor	112						integral to membrane					0	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.0176)		AGGTGAATTCCAACAGTTGGA	0.428													G	190147491	G	G	190147491	3	3	146	1	0	0	0	0	1	0	0	0	16129	603	21	5	110	5	TMEM207	3	190147491	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	11230640	190147491	7874939	20	10023											
CPEB2	132864	broad.mit.edu	37	chr4	15005738	15005739	+	In_Frame_Ins	INS	-	GCG	GCG													tgggctcagcgttccgacgaINSgcggcggcggcggcggcggc							TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr4:15005738_15005739insGCG	uc003gni.1	+	1	217_218	c.130_131insGCG	c.(130-132)AGC>AGCGGC	p.50_51insG	uc003gng.3_5'Flank|uc003gnh.1_5'Flank|CPEB2_uc003gnj.1_In_Frame_Ins_p.50_51insG|CPEB2_uc003gnk.1_In_Frame_Ins_p.50_51insG|CPEB2_uc003gnl.1_In_Frame_Ins_p.50_51insG|CPEB2_uc003gnm.1_In_Frame_Ins_p.50_51insG|CPEB2_uc003gnn.1_In_Frame_Ins_p.50_51insG	NM_182485	NP_872291	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding	50_51	Pro-rich.				regulation of translation	cytoplasm	nucleotide binding|RNA binding			skin(1)	1						CGTTCCGACGAgcggcggcggc	0.545													GCG	15005739	GCG	GCG	15005738	7	5	146	1	0	1	1	0	0	0	0	0	3801	304	11	0	1443	0	CPEB2	4	15005738	In_Frame_Ins	INS	-	TCGA-15-0742-01A-01W-0348-08		15005738	176148538	21	10024											
CCDC158	339965	broad.mit.edu	37	chr4	77305567	77305567	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggactgactctcccttcGtctatgaaataaatgaaaga	8	9	2	4			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr4:77305567G>A	uc003hkb.3	-	5	553	c.400C>T	c.(400-402)CGA>TGA	p.R134*	CCDC158_uc003hkd.2_Nonsense_Mutation_p.R134*	NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	134	Potential.									skin(3)|ovary(2)|pancreas(1)	6						CTCTCCCTTCGTCTATGAAAT	0.313													A	77305567	A	A	77305567	4	1	146	1	0	0	0	0	0	1	0	0	2790	1159	40	1	3021	1	CCDC158	4	77305567	Nonsense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	62299829	77305567	113848709	22	10025											
HEATR7B2	133558	broad.mit.edu	37	chr5	41051102	41051102	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggcattccaatgaccagtgGgtccagggtttttaagacct	11	9	0	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr5:41051102G>T	uc003jmj.3	-	13	1811	c.1321C>A	c.(1321-1323)CCA>ACA	p.P441T	HEATR7B2_uc003jmi.3_5'UTR	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	441	HEAT 5.						binding			ovary(6)|central_nervous_system(2)	8						ATGACCAGTGGGTCCAGGGTT	0.408													T	41051102	T	T	41051102	3	4	146	1	0	0	0	0	1	0	0	0	7035	1232	43	5	3556	5	HEATR7B2	5	41051102	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08		41051102	139864158	23	10026											
SNX24	28966	broad.mit.edu	37	chr5	122281829	122281829	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caaagtcttggaacagcgacGacaaggcttggaaacatact	10	9	1	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr5:122281829G>A	uc011cwo.1	+	3	393	c.224G>A	c.(223-225)CGA>CAA	p.R75Q	SNX24_uc003ktf.2_Missense_Mutation_p.R75Q|SNX24_uc010jcy.2_Missense_Mutation_p.R75Q	NM_014035	NP_054754	Q9Y343	SNX24_HUMAN	SBBI31 protein	75	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		GAACAGCGACGACAAGGCTTG	0.348													A	122281829	A	A	122281829	3	1	146	1	0	0	0	0	1	0	0	0	14895	1058	37	2	234	2	SNX24	5	122281829	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	81230727	122281829	58633431	24	10027											
SLC25A2	83884	broad.mit.edu	37	chr5	140682773	140682773	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgacaagccacaggcaaatTccagcaactccaccacttaa	5	15	0	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr5:140682773T>C	uc003ljf.2	-	1	840	c.660A>G	c.(658-660)GGA>GGG	p.G220G		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	220	Solcar 3.|Helical; Name=5; (Potential).				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	ACAGGCAAATTCCAGCAACTC	0.443													C	140682773	C	C	140682773	2	2	146	1	0	0	0	0	0	0	0	1	14482	1770	62	4		4	SLC25A2	5	140682773	Silent	SNP	T	TCGA-15-0742-01A-01W-0348-08	18400944	140682773	40232487	25	10028											
G3BP1	10146	broad.mit.edu	37	chr5	151170550	151170550	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaatgatggtgtggtagtccAggtgatggggcttctctcta	14	6	2	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr5:151170550A>G	uc003lun.2	+	4	449	c.278A>G	c.(277-279)CAG>CGG	p.Q93R	G3BP1_uc010jhy.1_Missense_Mutation_p.Q93R|G3BP1_uc003lum.2_Missense_Mutation_p.Q93R|G3BP1_uc011dcu.1_5'UTR|G3BP1_uc010jhz.2_5'UTR	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	93	NTF2.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			GTGGTAGTCCAGGTGATGGGG	0.453													G	151170550	G	G	151170550	3	3	146	1	0	0	0	0	1	0	0	0	6141	188	7	4	288	4	G3BP1	5	151170550	Missense_Mutation	SNP	A	TCGA-15-0742-01A-01W-0348-08	10487777	151170550	29744710	26	10029											
MDC1	9656	broad.mit.edu	37	chr6	30671524	30671524	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tccatggtagctaaagacctCttgcggctttgagaggcctt	11	10	1	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr6:30671524C>G	uc003nrg.3	-	10	5876	c.5436G>C	c.(5434-5436)AAG>AAC	p.K1812N	MDC1_uc003nrf.3_Missense_Mutation_p.K443N|MDC1_uc011dmp.1_Missense_Mutation_p.K1419N	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1812	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CTAAAGACCTCTTGCGGCTTT	0.498								Other_conserved_DNA_damage_response_genes					G	30671524	G	G	30671524	3	3	146	1	0	0	0	0	1	0	0	0	9403	912	32	5	857	5	MDC1	6	30671524	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08		30671524	140443543	27	10030											
KIAA1586	57691	broad.mit.edu	37	chr6	56918065	56918065	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcaatactgtttacagtttAgtaaaacataacagaccttt	4	7	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr6:56918065A>C	uc003pdj.2	+	4	938	c.768A>C	c.(766-768)TTA>TTC	p.L256F	KIAA1586_uc011dxm.1_Missense_Mutation_p.L229F	NM_020931	NP_065982	Q9HCI6	K1586_HUMAN	hypothetical protein LOC57691	256							nucleic acid binding				0	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTTACAGTTTAGTAAAACATA	0.279													C	56918065	C	C	56918065	3	2	146	1	0	0	0	0	1	0	0	0	8245	417	15	5	782	5	KIAA1586	6	56918065	Missense_Mutation	SNP	A	TCGA-15-0742-01A-01W-0348-08	26246541	56918065	114197002	28	10031											
KCNQ5	56479	broad.mit.edu	37	chr6	73904449	73904449	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtgcccagactttctacgCgcttagccctactatgcaca	7	15	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr6:73904449C>T	uc003pgk.2	+	14	2458	c.2111C>T	c.(2110-2112)GCG>GTG	p.A704V	KCNQ5_uc011dyh.1_Missense_Mutation_p.A723V|KCNQ5_uc011dyi.1_Missense_Mutation_p.A714V|KCNQ5_uc010kat.2_Missense_Mutation_p.A695V|KCNQ5_uc011dyj.1_Missense_Mutation_p.A594V|KCNQ5_uc011dyk.1_Missense_Mutation_p.A454V	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	704					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		ACTTTCTACGCGCTTAGCCCT	0.488													T	73904449	T	T	73904449	3	4	146	1	0	0	0	0	1	0	0	0	8086	768	27	1	2226	1	KCNQ5	6	73904449	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	16986384	73904449	97210618	29	10032											
IMPG1	3617	broad.mit.edu	37	chr6	76751736	76751736	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttgccaaatcgaatattcGtctcatagttgacattttgt	6	8	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr6:76751736G>A	uc003pik.1	-	2	305	c.175C>T	c.(175-177)CGA>TGA	p.R59*		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	59					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TCGAATATTCGTCTCATAGTT	0.363													A	76751736	A	A	76751736	4	1	146	1	0	0	0	0	0	1	0	0	7728	1153	40	1	2282	1	IMPG1	6	76751736	Nonsense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	2847287	76751736	94363331	30	10033											
NOX3	50508	broad.mit.edu	37	chr6	155776184	155776184	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttacacccaaaataactcgtGtgtaatggaaagactcctcc	6	11	0	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr6:155776184G>A	uc003qqm.2	-	2	231	c.128C>T	c.(127-129)ACA>ATA	p.T43I		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	43	Extracellular (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		AATAACTCGTGTGTAATGGAA	0.343													A	155776184	A	A	155776184	3	1	146	1	0	0	0	0	1	0	0	0	10557	1377	48	3	1626	3	NOX3	6	155776184	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	79024448	155776184	15338883	31	10034											
EGFR	1956	broad.mit.edu	37	chr7	55238894	55238894	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggccaggtcttgaaggctGtccaacgaatgggtaagtgt	15	7	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr7:55238894G>A	uc003tqk.2	+	16	2153	c.1907G>A	c.(1906-1908)TGT>TAT	p.C636Y	EGFR_uc010kzg.1_Missense_Mutation_p.C591Y|EGFR_uc011kco.1_Missense_Mutation_p.C583Y|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	636	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.C636Y(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTTGAAGGCTGTCCAACGAAT	0.423		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55238894	A	A	55238894	3	1	146	1	0	0	0	0	1	0	0	0	4967	1377	48	3	2233	3	EGFR	7	55238894	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08		55238894	103899769	32	10035											
CCL24	6369	broad.mit.edu	37	chr7	75442963	75442963	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctgtcggaggtcttacccGtagggatgatgtggtgggca	16	8	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr7:75442963G>A	uc011kga.1	-	1	71	c.71C>T	c.(70-72)ACG>ATG	p.T24M		NM_002991	NP_002982	O00175	CCL24_HUMAN	small inducible cytokine A24 precursor	24					cell-cell signaling|chemotaxis|immune response|inflammatory response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|signal transduction	extracellular space	chemokine activity				0						GGTCTTACCCGTAGGGATGAT	0.612													A	75442963	A	A	75442963	3	1	146	1	0	0	0	0	1	0	0	0	2896	1145	40	1	298	1	CCL24	7	75442963	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	20204069	75442963	83695700	33	10036											
HGF	3082	broad.mit.edu	37	chr7	81331979	81331979	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcggacaaaaataccaggaCgatttggaatggcacatcca	9	10	0	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr7:81331979C>T	uc003uhl.2	-	18	2270	c.2105G>A	c.(2104-2106)CGT>CAT	p.R702H	HGF_uc003uhm.2_Missense_Mutation_p.R697H	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	702	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						AATACCAGGACGATTTGGAAT	0.403													T	81331979	T	T	81331979	3	4	146	1	0	0	0	0	1	0	0	0	7085	536	19	1	85	1	HGF	7	81331979	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	5889016	81331979	77806684	34	10037											
ZNF804B	219578	broad.mit.edu	37	chr7	88963595	88963595	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttgtaaaagaagcatgtacCcataatgtggcatctaaacc	7	9	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr7:88963595C>A	uc011khi.1	+	4	1837	c.1299C>A	c.(1297-1299)ACC>ACA	p.T433T		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	433						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AAGCATGTACCCATAATGTGG	0.373										HNSCC(36;0.09)			A	88963595	A	A	88963595	2	1	146	1	0	0	0	0	0	0	0	1	18168	610	22	5		5	ZNF804B	7	88963595	Silent	SNP	C	TCGA-15-0742-01A-01W-0348-08	7631616	88963595	70175068	35	10038											
COL1A2	1278	broad.mit.edu	37	chr7	94055328	94055328	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agggtccttctggtcctgttGgtcctgctggtgctgttggc	15	10	1	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr7:94055328G>C	uc003ung.1	+	45	3433	c.2962G>C	c.(2962-2964)GGT>CGT	p.G988R	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	988					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGGTCCTGTTGGTCCTGCTGG	0.478										HNSCC(75;0.22)			C	94055328	C	C	94055328	3	2	146	1	0	0	0	0	1	0	0	0	3678	1348	47	5	3140	5	COL1A2	7	94055328	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	5091733	94055328	65083335	36	10039											
SLC26A3	1811	broad.mit.edu	37	chr7	107434196	107434196	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaattttaccttgtagtaCggccacaatccctgtgctga	7	10	0	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr7:107434196C>T	uc003ver.2	-	3	473	c.262G>A	c.(262-264)GTA>ATA	p.V88I	SLC26A3_uc003ves.2_Missense_Mutation_p.V53I	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	88	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						ccttGTAGTACGGCCACAATC	0.254													T	107434196	T	T	107434196	3	4	146	1	0	0	0	0	1	0	0	0	14518	536	19	1	2108	1	SLC26A3	7	107434196	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	13378868	107434196	51704467	37	10040											
SPAM1	6677	broad.mit.edu	37	chr7	123595133	123595133	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggaaccctcagtataatgcGaagtatggtaagttgaattg	12	5	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr7:123595133G>A	uc003vld.2	+	5	1439	c.1037G>A	c.(1036-1038)CGA>CAA	p.R346Q	SPAM1_uc003vle.2_Missense_Mutation_p.R346Q|SPAM1_uc011koa.1_Missense_Mutation_p.R2Q|SPAM1_uc003vlf.3_Missense_Mutation_p.R346Q|SPAM1_uc010lku.2_Missense_Mutation_p.R346Q	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	346					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	AGTATAATGCGAAGTATGGTA	0.294													A	123595133	A	A	123595133	3	1	146	1	0	0	0	0	1	0	0	0	14986	1058	37	2	1043	2	SPAM1	7	123595133	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	16160937	123595133	35543530	38	10041											
SVOPL	136306	broad.mit.edu	37	chr7	138310791	138310791	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagaggaagccaatcaggcCggcactagaaaacaggaagc	13	9	1	2	rs144549446		TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr7:138310791C>T	uc011kqh.1	-	12	1186	c.1186G>A	c.(1186-1188)GGC>AGC	p.G396S	SVOPL_uc003vue.2_Missense_Mutation_p.G244S	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	396	Helical; (Potential).					integral to membrane	transmembrane transporter activity				0						CCAATCAGGCCGGCACTAGAA	0.507													T	138310791	T	T	138310791	3	4	146	1	0	0	0	0	1	0	0	0	15421	652	23	2	308	2	SVOPL	7	138310791	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	14715658	138310791	20827872	39	10042											
RIMS2	9699	broad.mit.edu	37	chr8	105001550	105001550	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtcggaatgtggaacaggGgcttcgagggacccgcacta	15	9	0	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr8:105001550G>A	uc003yls.2	+	15	2520	c.2279G>A	c.(2278-2280)GGG>GAG	p.G760E	RIMS2_uc003ylp.2_Missense_Mutation_p.G982E|RIMS2_uc003ylw.2_Missense_Mutation_p.G774E|RIMS2_uc003ylq.2_Missense_Mutation_p.G774E|RIMS2_uc003ylr.2_Missense_Mutation_p.G821E	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1044					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTGGAACAGGGGCTTCGAGGG	0.398										HNSCC(12;0.0054)			A	105001550	A	A	105001550	3	1	146	1	0	0	0	0	1	0	0	0	13368	1232	43	3	3137	3	RIMS2	8	105001550	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08		105001550	41362472	40	10043											
CSMD3	114788	broad.mit.edu	37	chr8	114290824	114290824	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccactaccatcacttaccttCgtaatataccttaaatccat	1	14	1	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr8:114290824C>T	uc003ynu.2	-	3	670	c.511G>A	c.(511-513)GAA>AAA	p.E171K	CSMD3_uc003ynt.2_Missense_Mutation_p.E131K|CSMD3_uc011lhx.1_Missense_Mutation_p.E171K|CSMD3_uc010mcx.1_Missense_Mutation_p.E171K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	171	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACTTACCTTCGTAATATACC	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			T	114290824	T	T	114290824	3	4	146	1	0	0	0	0	1	0	0	0	3946	893	31	2	10888	2	CSMD3	8	114290824	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	9289274	114290824	32073198	41	10044											
IFNA21	3452	broad.mit.edu	37	chr9	21166247	21166247	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccccaacctcctgtatcacgCaggcttccaggtcattcagc	7	17	3	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr9:21166247C>G	uc003zom.2	-	1	413	c.365G>C	c.(364-366)TGC>TCC	p.C122S		NM_002175	NP_002166	P01568	IFN21_HUMAN	interferon, alpha 21 precursor	122					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTGTATCACGCAGGCTTCCAG	0.463													G	21166247	G	G	21166247	3	3	146	1	0	0	0	0	1	0	0	0	7538	710	25	5	208	5	IFNA21	9	21166247	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08		21166247	120047184	42	10045											
S1PR3	1903	broad.mit.edu	37	chr9	91616623	91616623	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcattgccttcacgctgggcGccctgcccattctgggctgg	12	15	3	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr9:91616623G>A	uc004aqe.2	+	2	904	c.508G>A	c.(508-510)GCC>ACC	p.A170T		NM_005226	NP_005217	Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	170	Helical; Name=4; (By similarity).				anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity	p.A170A(1)		ovary(2)|lung(1)|central_nervous_system(1)|skin(1)	5						CACGCTGGGCGCCCTGCCCAT	0.557											OREG0019291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	91616623	A	A	91616623	3	1	146	1	0	0	0	0	1	0	0	0	13795	1087	38	1	510	1	S1PR3	9	91616623	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	70450376	91616623	49596808	43	10046											
SURF4	6836	broad.mit.edu	37	chr9	136230519	136230519	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggaatggtccagaaggcGttgaaatatacgttgatggc	13	6	0	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr9:136230519G>A	uc004cdj.2	-	6	790	c.660C>T	c.(658-660)AAC>AAT	p.N220N	SURF4_uc011mda.1_Silent_p.N211N|SURF4_uc010nal.2_3'UTR|SURF4_uc011mdb.1_Silent_p.N177N|SURF4_uc011mdc.1_Silent_p.N177N|SURF4_uc011mdd.1_3'UTR	NM_033161	NP_149351	O15260	SURF4_HUMAN	surfeit 4	220	Helical; (Potential).					endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		TCCAGAAGGCGTTGAAATATA	0.488													A	136230519	A	A	136230519	2	1	146	1	0	0	0	0	0	0	0	1	15402	1136	40	1		1	SURF4	9	136230519	Silent	SNP	G	TCGA-15-0742-01A-01W-0348-08	44613896	136230519	4982912	44	10047											
LCN1	3933	broad.mit.edu	37	chr9	138415760	138415760	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggcatacatcatcaggtcGcacgtgaaggaccactacat	10	11	2	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr9:138415760G>A	uc004cfz.1	+	4	385	c.327G>A	c.(325-327)TCG>TCA	p.S109S	LCN1_uc004cga.1_Silent_p.S109S	NM_002297	NP_002288	P31025	LCN1_HUMAN	lipocalin 1 precursor	109					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		TCATCAGGTCGCACGTGAAGG	0.602													A	138415760	A	A	138415760	2	1	146	1	0	0	0	0	0	0	0	1	8680	1074	38	1		1	LCN1	9	138415760	Silent	SNP	G	TCGA-15-0742-01A-01W-0348-08	2185241	138415760	2797671	45	10048											
PTCHD3	374308	broad.mit.edu	37	chr10	27688091	27688091	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cttttgaatagacattggacAtccgctctcgtatgtcatct	7	10	3	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr10:27688091A>T	uc001itu.2	-	4	1554	c.1436T>A	c.(1435-1437)ATG>AAG	p.M479K		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	479	SSD.				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GACATTGGACATCCGCTCTCG	0.403													T	27688091	T	T	27688091	3	4	146	1	0	0	0	0	1	0	0	0	12734	217	8	5	871	5	PTCHD3	10	27688091	Missense_Mutation	SNP	A	TCGA-15-0742-01A-01W-0348-08		27688091	107846656	46	10049											
TRIM3	10612	broad.mit.edu	37	chr11	6470405	6470405	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	aggaaggagccagagctgtcGaatacctggggaaggagtgc	17	7	0	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr11:6470405G>C	uc001mdh.2	-	13	2475	c.2088C>G	c.(2086-2088)TTC>TTG	p.F696L	TRIM3_uc001mdi.2_Missense_Mutation_p.F696L|TRIM3_uc010raj.1_Missense_Mutation_p.F577L|TRIM3_uc009yfd.2_Missense_Mutation_p.F696L	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	696	NHL 5.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGAGCTGTCGAATACCTGGG	0.562													C	6470405	C	C	6470405	3	2	146	1	0	0	0	0	1	0	0	0	16501	1049	37	5	150	5	TRIM3	11	6470405	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08		6470405	128536111	47	10050											
SYT9	143425	broad.mit.edu	37	chr11	7324279	7324279	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttctttgcagatatctcagTgagcctgctgacccttgtgg	10	11	2	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr11:7324279T>C	uc001mfe.2	+	2	392	c.155T>C	c.(154-156)GTG>GCG	p.V52A	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	52	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GATATCTCAGTGAGCCTGCTG	0.537													C	7324279	C	C	7324279	3	2	146	1	0	0	0	0	1	0	0	0	15478	1696	59	4	161	4	SYT9	11	7324279	Missense_Mutation	SNP	T	TCGA-15-0742-01A-01W-0348-08	853874	7324279	127682237	48	10051											
ANO1	55107	broad.mit.edu	37	chr11	69924755	69924755	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgacgctcccggccgaggacCgcagcgtccacatcatcaac	10	18	2	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr11:69924755C>T	uc001opj.2	+	1	348	c.43C>T	c.(43-45)CGC>TGC	p.R15C		NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	15	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						GGCCGAGGACCGCAGCGTCCA	0.731													T	69924755	T	T	69924755	3	4	146	1	0	0	0	0	1	0	0	0	695	652	23	2	45	2	ANO1	11	69924755	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	62600476	69924755	65081761	49	10052											
NOX4	50507	broad.mit.edu	37	chr11	89155085	89155085	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttaccctgaaacatgcaacGtcagcagcatgtagaagaca	8	11	1	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr11:89155085G>A	uc001pct.2	-	8	853	c.614C>T	c.(613-615)ACG>ATG	p.T205M	NOX4_uc009yvr.2_Missense_Mutation_p.T180M|NOX4_uc001pcu.2_Missense_Mutation_p.T131M|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Missense_Mutation_p.T205M|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.T39M|NOX4_uc009yvp.2_Missense_Mutation_p.T205M|NOX4_uc010rtv.1_Missense_Mutation_p.T181M|NOX4_uc009yvq.2_Missense_Mutation_p.T181M|NOX4_uc009yvs.1_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	205	Helical; (Potential).|Ferric oxidoreductase.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AACATGCAACGTCAGCAGCAT	0.333													A	89155085	A	A	89155085	3	1	146	1	0	0	0	0	1	0	0	0	10558	1145	40	1	1166	1	NOX4	11	89155085	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	19230330	89155085	45851431	50	10053											
CARD16	114769	broad.mit.edu	37	chr11	104915384	104915384	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcttctccttcaggaccttGtctgtttggagcacaaggat	9	11	4	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr11:104915384G>T	uc001pip.1	-	2	36	c.9C>A	c.(7-9)GAC>GAA	p.D3E	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_Missense_Mutation_p.D3E	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	3	CARD.				regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						TCAGGACCTTGTCTGTTTGGA	0.408													T	104915384	T	T	104915384	3	4	146	1	0	0	0	0	1	0	0	0	2647	1391	48	5	616	5	CARD16	11	104915384	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	15760299	104915384	30091132	51	10054											
OLR1	4973	broad.mit.edu	37	chr12	10319338	10319338	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atttgctactctcttcagtgTttcttggagattcagattct	7	8	5	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr12:10319338T>A	uc001qxo.1	-	3	511	c.397A>T	c.(397-399)ACA>TCA	p.T133S	OLR1_uc010sgz.1_Missense_Mutation_p.T29S|OLR1_uc010sha.1_Missense_Mutation_p.T133S	NM_002543	NP_002534	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like)	133	Extracellular (Potential).|Neck.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			ovary(1)	1						CTCTTCAGTGTTTCTTGGAGA	0.403													A	10319338	A	A	10319338	3	1	146	1	0	0	0	0	1	0	0	0	10863	1725	60	5	440	5	OLR1	12	10319338	Missense_Mutation	SNP	T	TCGA-15-0742-01A-01W-0348-08		10319338	123532557	52	10055											
CSRNP2	81566	broad.mit.edu	37	chr12	51457947	51457947	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtaggatgggctgttcaccGttgaggcagttgggtggtct	17	6	2	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr12:51457947G>A	uc001rxu.1	-	5	1512	c.1214C>T	c.(1213-1215)ACG>ATG	p.T405M		NM_030809	NP_110436	Q9H175	CSRN2_HUMAN	TGF-beta induced apoptosis protein 12	405					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GCTGTTCACCGTTGAGGCAGT	0.567													A	51457947	A	A	51457947	3	1	146	1	0	0	0	0	1	0	0	0	3964	1145	40	1	421	1	CSRNP2	12	51457947	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	41138609	51457947	82393948	53	10056											
MYO1A	4640	broad.mit.edu	37	chr12	57430106	57430106	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cttaccatgctcttgtagatGaaatctgccaaggtgagggc	11	9	2	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr12:57430106G>T	uc001smw.3	-	22	2577	c.2334C>A	c.(2332-2334)TTC>TTA	p.F778L	MYO1A_uc010sqz.1_Missense_Mutation_p.F616L|MYO1A_uc009zpd.2_Missense_Mutation_p.F778L	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	778					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						TCTTGTAGATGAAATCTGCCA	0.502													T	57430106	T	T	57430106	3	4	146	1	0	0	0	0	1	0	0	0	10068	1281	45	5	825	5	MYO1A	12	57430106	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	5972159	57430106	76421789	54	10057											
IL22	50616	broad.mit.edu	37	chr12	68646552	68646552	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgtagcttacactgactcCgtggaacagtttctccccaa	7	13	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr12:68646552C>T	uc001sty.1	-	2	297	c.244G>A	c.(244-246)GGA>AGA	p.G82R	IL22_uc010stb.1_Missense_Mutation_p.G82R	NM_020525	NP_065386	Q9GZX6	IL22_HUMAN	interleukin 22 precursor	82					acute-phase response	extracellular space	cytokine activity|interleukin-22 receptor binding				0		Myeloproliferative disorder(1001;0.0255)	Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;5.06e-05)|BRCA - Breast invasive adenocarcinoma(357;0.00104)		ACACTGACTCCGTGGAACAGT	0.498													T	68646552	T	T	68646552	3	4	146	1	0	0	0	0	1	0	0	0	7672	661	23	2	311	2	IL22	12	68646552	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	11216446	68646552	65205343	55	10058											
MDM1	56890	broad.mit.edu	37	chr12	68719231	68719231	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attaagctacctgattggctGcaaaagctggagcagtttct	10	8	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr12:68719231G>A	uc001stz.2	-	4	759	c.623C>T	c.(622-624)GCA>GTA	p.A208V	MDM1_uc010stc.1_Intron|MDM1_uc009zqv.1_5'UTR|MDM1_uc001sua.3_3'UTR|MDM1_uc010std.1_3'UTR	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	208						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		CTGATTGGCTGCAAAAGCTGG	0.338													A	68719231	A	A	68719231	3	1	146	1	0	0	0	0	1	0	0	0	9412	1319	46	3	1565	3	MDM1	12	68719231	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	72679	68719231	65132664	56	10059											
KCNC2	3747	broad.mit.edu	37	chr12	75444575	75444575	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aggttgagctcccactctctCggcatagtagatcatggtag	11	10	2	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr12:75444575C>T	uc001sxg.1	-	3	1754	c.1210G>A	c.(1210-1212)GAG>AAG	p.E404K	KCNC2_uc009zry.2_Missense_Mutation_p.E404K|KCNC2_uc001sxe.2_Missense_Mutation_p.E404K|KCNC2_uc001sxf.2_Missense_Mutation_p.E404K|KCNC2_uc010stw.1_Missense_Mutation_p.E404K	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	404					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						CCCACTCTCTCGGCATAGTAG	0.448													T	75444575	T	T	75444575	3	4	146	1	0	0	0	0	1	0	0	0	8015	893	31	2	784	2	KCNC2	12	75444575	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	6725344	75444575	58407320	57	10060											
RIMBP2	23504	broad.mit.edu	37	chr12	130927141	130927141	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcttgccaaccgcgactcGttgtcctgcacaaagtccac	9	15	0	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr12:130927141G>A	uc001uil.2	-	8	869	c.705C>T	c.(703-705)AAC>AAT	p.N235N	RIMBP2_uc001uim.2_Silent_p.N143N|RIMBP2_uc001uin.1_Translation_Start_Site	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	235						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		ACCGCGACTCGTTGTCCTGCA	0.582													A	130927141	A	A	130927141	2	1	146	1	0	0	0	0	0	0	0	1	13363	1136	40	1		1	RIMBP2	12	130927141	Silent	SNP	G	TCGA-15-0742-01A-01W-0348-08	55482566	130927141	2924754	58	10061											
EP400	57634	broad.mit.edu	37	chr12	132490816	132490816	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcggtggctgaagccatccTgccgaagggcagtgctcggg	17	11	0	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr12:132490816T>G	uc001ujn.2	+	13	3130	c.3095T>G	c.(3094-3096)CTG>CGG	p.L1032R	EP400_uc001ujl.2_Missense_Mutation_p.L1031R|EP400_uc001ujm.2_Missense_Mutation_p.L1032R	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1068	Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GAAGCCATCCTGCCGAAGGGC	0.542													G	132490816	G	G	132490816	3	3	146	1	0	0	0	0	1	0	0	0	5149	1580	55	5	3142	5	EP400	12	132490816	Missense_Mutation	SNP	T	TCGA-15-0742-01A-01W-0348-08	1563675	132490816	1361079	59	10062											
TSSK4	283629	broad.mit.edu	37	chr14	24675764	24675764	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcaacttctatcgggccaTtgagagcacatctcgagtat	8	11	3	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr14:24675764T>C	uc001wng.2	+	2	443	c.275T>C	c.(274-276)ATT>ACT	p.I92T	TM9SF1_uc010tob.1_Intron|TSSK4_uc001wne.2_Missense_Mutation_p.I16T|TSSK4_uc001wnf.2_5'UTR|TSSK4_uc001wnh.2_Missense_Mutation_p.I92T	NM_174944	NP_777604	Q6SA08	TSSK4_HUMAN	testis-specific serine kinase 4	92	Protein kinase.				cell differentiation|multicellular organismal development|positive regulation of CREB transcription factor activity|spermatogenesis		ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity				0				GBM - Glioblastoma multiforme(265;0.018)		TATCGGGCCATTGAGAGCACA	0.532													C	24675764	C	C	24675764	3	2	146	1	0	0	0	0	1	0	0	0	16668	1493	52	4	281	4	TSSK4	14	24675764	Missense_Mutation	SNP	T	TCGA-15-0742-01A-01W-0348-08		24675764	82673776	60	10063											
LTBP2	4053	broad.mit.edu	37	chr14	74969471	74969471	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggaaggcaggctcagggacGgtgtcctcggggcccaggta	19	10	1	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr14:74969471G>A	uc001xqa.2	-	34	5442	c.5055C>T	c.(5053-5055)ACC>ACT	p.T1685T		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1685					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GCTCAGGGACGGTGTCCTCGG	0.637													A	74969471	A	A	74969471	2	1	146	1	0	0	0	0	0	0	0	1	9074	1103	39	2		2	LTBP2	14	74969471	Silent	SNP	G	TCGA-15-0742-01A-01W-0348-08	50293707	74969471	32380069	61	10064											
PROX2	283571	broad.mit.edu	37	chr14	75329549	75329549	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtgcagtcaagggaaagtttGctgggggatcctgacagggt	17	6	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr14:75329549G>C	uc001xqr.1	-	1	989	c.989C>G	c.(988-990)GCA>GGA	p.A330G	PROX2_uc001xqq.1_Intron	NM_001080408	NP_001073877	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	330					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GGGAAAGTTTGCTGGGGGATC	0.502													C	75329549	C	C	75329549	3	2	146	1	0	0	0	0	1	0	0	0	12561	1319	46	5	805	5	PROX2	14	75329549	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	360078	75329549	32019991	62	10065											
MESDC2	23184	broad.mit.edu	37	chr15	81282094	81282094	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agcaggtcagaggcacaaagCaggaccacggccttgcgcgc	14	13	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr15:81282094C>A	uc002bfy.1	-	1	112	c.39G>T	c.(37-39)CTG>CTT	p.L13L	MESDC2_uc002bfx.2_RNA|MESDC2_uc010uno.1_RNA	NM_015154	NP_055969	Q14696	MESD_HUMAN	mesoderm development candidate 2	13	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum					0						AGGCACAAAGCAGGACCACGG	0.652													A	81282094	A	A	81282094	2	1	146	1	0	0	0	0	0	0	0	1	9481	697	25	5		5	MESDC2	15	81282094	Silent	SNP	C	TCGA-15-0742-01A-01W-0348-08		81282094	21249298	63	10066											
CPPED1	55313	broad.mit.edu	37	chr16	12875067	12875067	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggcgtggatgaggtcgccGcacagaacgaagaatttggg	16	7	0	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr16:12875067G>A	uc002dca.3	-	2	375	c.264C>T	c.(262-264)TGC>TGT	p.C88C	CPPED1_uc002dcb.3_Silent_p.C88C	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	88							hydrolase activity|metal ion binding				0						TGAGGTCGCCGCACAGAACGA	0.532													A	12875067	A	A	12875067	2	1	146	1	0	0	0	0	0	0	0	1	3822	1079	38	1		1	CPPED1	16	12875067	Silent	SNP	G	TCGA-15-0742-01A-01W-0348-08		12875067	77479686	64	10067											
CIRH1A	84916	broad.mit.edu	37	chr16	69201051	69201051	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcagatgtcatccggaggcGcacagctcatgcttttaaaa	9	10	3	1	rs34057086	byFrequency	TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr16:69201051G>A	uc002ews.3	+	16	2003	c.1907G>A	c.(1906-1908)CGC>CAC	p.R636H	CIRH1A_uc002ewr.2_3'UTR|CIRH1A_uc002ewt.3_Missense_Mutation_p.R553H|CIRH1A_uc010cfi.2_Missense_Mutation_p.R438H	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	636						nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		ATCCGGAGGCGCACAGCTCAT	0.348													A	69201051	A	A	69201051	3	1	146	1	0	0	0	0	1	0	0	0	3434	1087	38	1	1965	1	CIRH1A	16	69201051	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	56325984	69201051	21153702	65	10068											
MYH2	4620	broad.mit.edu	37	chr17	10430055	10430055	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctcctcatactgttcccGcagcaggtcacagtcgtggc	9	16	2	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr17:10430055G>A	uc010coi.2	-	30	4176	c.4048C>T	c.(4048-4050)CGG>TGG	p.R1350W	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1350W|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1350	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TACTGTTCCCGCAGCAGGTCA	0.547													A	10430055	A	A	10430055	3	1	146	1	0	0	0	0	1	0	0	0	10035	1086	38	1	1821	1	MYH2	17	10430055	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08		10430055	70765155	66	10069											
JMJD6	23210	broad.mit.edu	37	chr17	74721588	74721588	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctccccagcatactggaaaAggtcatcagtgaaaaacttt	7	10	3	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr17:74721588A>G	uc002jso.2	-	2	803	c.479T>C	c.(478-480)CTT>CCT	p.L160P	JMJD6_uc002jsn.1_Missense_Mutation_p.L160P|JMJD6_uc010dgz.2_Missense_Mutation_p.L160P|C17orf95_uc002jsp.2_5'Flank|C17orf95_uc002jsq.2_5'Flank|C17orf95_uc002jsr.2_5'Flank|C17orf95_uc002jss.2_5'Flank|C17orf95_uc002jst.2_5'Flank|C17orf95_uc002jsu.2_5'Flank	NM_015167	NP_055982	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6 isoform 2	160	JmjC.				mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			skin(2)|ovary(1)	3						ATACTGGAAAAGGTCATCAGT	0.383													G	74721588	G	G	74721588	3	3	146	1	0	0	0	0	1	0	0	0	7953	72	3	4	793	4	JMJD6	17	74721588	Missense_Mutation	SNP	A	TCGA-15-0742-01A-01W-0348-08	64291533	74721588	6473622	67	10070											
PTPRM	5797	broad.mit.edu	37	chr18	7888281	7888281	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaaggtcaataacgggccacTggggaatcctatctggaata	12	8	2	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr18:7888281T>A	uc002knn.3	+	3	877	c.374T>A	c.(373-375)CTG>CAG	p.L125Q	PTPRM_uc010dkv.2_Missense_Mutation_p.L125Q	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	125	MAM.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				AACGGGCCACTGGGGAATCCT	0.453													A	7888281	A	A	7888281	3	1	146	1	0	0	0	0	1	0	0	0	12806	1580	55	5	384	5	PTPRM	18	7888281	Missense_Mutation	SNP	T	TCGA-15-0742-01A-01W-0348-08		7888281	70188967	68	10071											
CTAGE1	64693	broad.mit.edu	37	chr18	19997860	19997860	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttagccctaggctcctccGtagcgccaaggctgctctgg	13	14	1	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr18:19997860G>A	uc002ktv.1	-	1	19	c.-85C>T	c.(-87--83)TACGG>TATGG			NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1							integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGGCTCCTCCGTAGCGCCAAG	0.587													A	19997860	A	A	19997860	1	1	146	1	0	0	0	0	0	0	0	0	3992	1160	40	1		1	CTAGE1	18	19997860	Translation_Start_Site	SNP	G	TCGA-15-0742-01A-01W-0348-08	12109579	19997860	58079388	69	10072											
DCC	1630	broad.mit.edu	37	chr18	50734176	50734176	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgatgatataacagtggttaCactttctgacggtaagttaa	9	5	1	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr18:50734176C>G	uc002lfe.1	+	11	2437	c.1850C>G	c.(1849-1851)ACA>AGA	p.T617R	DCC_uc010xdr.1_Missense_Mutation_p.T465R|DCC_uc010dpf.1_Missense_Mutation_p.T272R	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	617	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ACAGTGGTTACACTTTCTGAC	0.338													G	50734176	G	G	50734176	3	3	146	1	0	0	0	0	1	0	0	0	4282	478	17	5	1892	5	DCC	18	50734176	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	30736316	50734176	27343072	70	10073											
MUC16	94025	broad.mit.edu	37	chr19	9067947	9067947	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttccacagagggtgggcttGtccctgatatgtactcagga	12	9	1	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr19:9067947G>C	uc002mkp.2	-	3	19703	c.19499C>G	c.(19498-19500)ACA>AGA	p.T6500R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6502	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGTGGGCTTGTCCCTGATAT	0.468													C	9067947	C	C	9067947	3	2	146	1	0	0	0	0	1	0	0	0	9973	1377	48	5	24352	5	MUC16	19	9067947	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08		9067947	50061036	71	10074											
GAPDHS	26330	broad.mit.edu	37	chr19	36029512	36029512	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtatgactccacccacggcCgatacaagggaagtgtggaa	12	10	0	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr19:36029512C>T	uc002oaf.1	+	4	492	c.376C>T	c.(376-378)CGA>TGA	p.R126*		NM_014364	NP_055179	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase,	126					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	CACCCACGGCCGATACAAGGG	0.522													T	36029512	T	T	36029512	4	4	146	1	0	0	0	0	0	1	0	0	6237	644	23	2	390	2	GAPDHS	19	36029512	Nonsense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	26961565	36029512	23099471	72	10075											
NLRP5	126206	broad.mit.edu	37	chr19	56539808	56539808	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtccgtatttgcggaaaattCgggtggatgtcaaagggatc	14	6	1	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr19:56539808C>T	uc002qmj.2	+	7	2209	c.2209C>T	c.(2209-2211)CGG>TGG	p.R737W	NLRP5_uc002qmi.2_Missense_Mutation_p.R718W	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	737	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCGGAAAATTCGGGTGGATGT	0.498													T	56539808	T	T	56539808	3	4	146	1	0	0	0	0	1	0	0	0	10480	875	31	2	2235	2	NLRP5	19	56539808	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	20510296	56539808	2589175	73	10076											
TMC2	117532	broad.mit.edu	37	chr20	2539347	2539347	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagggcctccttccaggagCggacagcagccccaaagagg	14	13	0	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr20:2539347C>T	uc002wgf.1	+	3	343	c.328C>T	c.(328-330)CGG>TGG	p.R110W	TMC2_uc002wgg.1_Missense_Mutation_p.R94W|TMC2_uc010zpw.1_5'UTR|TMC2_uc010zpx.1_5'UTR	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	110	Arg/Asp/Glu/Lys-rich (highly charged).|Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						CTTCCAGGAGCGGACAGCAGC	0.622													T	2539347	T	T	2539347	3	4	146	1	0	0	0	0	1	0	0	0	15982	759	27	1	338	1	TMC2	20	2539347	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08		2539347	60486173	74	10077											
C20orf111	51526	broad.mit.edu	37	chr20	42826177	42826177	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagagaagtagagctttctcCtgcactgaactctttagggg	12	8	2	3			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr20:42826177C>T	uc002xlk.2	-	4	531	c.394G>A	c.(394-396)GGA>AGA	p.G132R		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	132											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			GAGCTTTCTCCTGCACTGAAC	0.498													T	42826177	T	T	42826177	3	4	146	1	0	0	0	0	1	0	0	0	2080	690	24	3	488	3	C20orf111	20	42826177	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	40286830	42826177	20199343	75	10078											
PCK1	5105	broad.mit.edu	37	chr20	56138743	56138743	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgggtggaaggttgagtgCgtcggggatgacattgcctg	18	8	0	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr20:56138743C>T	uc002xyn.3	+	6	1084	c.921C>T	c.(919-921)TGC>TGT	p.C307C	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	307					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			AGGTTGAGTGCGTCGGGGATG	0.567													T	56138743	T	T	56138743	2	4	146	1	0	0	0	0	0	0	0	1	11581	776	27	1		1	PCK1	20	56138743	Silent	SNP	C	TCGA-15-0742-01A-01W-0348-08	13312566	56138743	6886777	76	10079											
C2CD2	25966	broad.mit.edu	37	chr21	43327136	43327136	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgccctccccacgtcgacgCgaggcttggtcttcacagca	10	17	2	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr21:43327136C>T	uc002yzw.2	-	10	1525	c.1283G>A	c.(1282-1284)CGC>CAC	p.R428H	C2CD2_uc002yzt.2_Missense_Mutation_p.R44H|C2CD2_uc002yzu.2_Missense_Mutation_p.R260H|C2CD2_uc002yzv.2_Missense_Mutation_p.R273H|C2CD2_uc002yzx.1_Missense_Mutation_p.R273H	NM_015500	NP_056315	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2 isoform	428						cytosol|extracellular region|nucleus				ovary(1)	1						CACGTCGACGCGAGGCTTGGT	0.592													T	43327136	T	T	43327136	3	4	146	1	0	0	0	0	1	0	0	0	2152	768	27	1	827	1	C2CD2	21	43327136	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08		43327136	4802759	77	10080											
ABCG1	9619	broad.mit.edu	37	chr21	43711761	43711761	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcggagccgcctccacgtccCtgcaggtgccagcccaggag	13	17	0	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr21:43711761C>T	uc002zaq.2	+	13	1790	c.1684C>T	c.(1684-1686)CTG>TTG	p.L562L	ABCG1_uc002zan.2_Silent_p.L552L|ABCG1_uc002zam.2_Silent_p.L528L|ABCG1_uc002zao.2_Silent_p.L547L|ABCG1_uc002zap.2_Silent_p.L550L|ABCG1_uc002zar.2_Silent_p.L561L|ABCG1_uc011aev.1_Silent_p.L573L|ABCG1_uc010gpb.1_Missense_Mutation_p.P202L	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	562	ABC transmembrane type-2.|Cytoplasmic (Potential).				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	CTCCACGTCCCTGCAGGTGCC	0.677													T	43711761	T	T	43711761	2	4	146	1	0	0	0	0	0	0	0	1	68	680	24	3		3	ABCG1	21	43711761	Silent	SNP	C	TCGA-15-0742-01A-01W-0348-08	384625	43711761	4418134	78	10081											
ITGB2	3689	broad.mit.edu	37	chr21	46320283	46320283	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctccaggtgacagcggccGtcgttgggggtcaggatggc	17	11	1	1	rs35013643	by1000genomes	TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr21:46320283G>A	uc002zgd.2	-	6	893	c.849C>T	c.(847-849)GAC>GAT	p.D283D	ITGB2_uc002zge.2_Silent_p.D283D|ITGB2_uc002zgf.3_Silent_p.D283D|ITGB2_uc011afl.1_Silent_p.D205D|ITGB2_uc010gpw.2_Silent_p.D226D|ITGB2_uc002zgg.2_Silent_p.D283D	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	283	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GACAGCGGCCGTCGTTGGGGG	0.642													A	46320283	A	A	46320283	2	1	146	1	0	0	0	0	0	0	0	1	7894	1136	40	1		1	ITGB2	21	46320283	Silent	SNP	G	TCGA-15-0742-01A-01W-0348-08	2608522	46320283	1809612	79	10082											
ITGB2	3689	broad.mit.edu	37	chr21	46320342	46320342	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cgcgaaatggaagccgtcatCagtggcaaacaccagcagcc	11	13	2	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr21:46320342C>A	uc002zgd.2	-	6	834	c.790G>T	c.(790-792)GAT>TAT	p.D264Y	ITGB2_uc002zge.2_Missense_Mutation_p.D264Y|ITGB2_uc002zgf.3_Missense_Mutation_p.D264Y|ITGB2_uc011afl.1_Missense_Mutation_p.D186Y|ITGB2_uc010gpw.2_Missense_Mutation_p.D207Y|ITGB2_uc002zgg.2_Missense_Mutation_p.D264Y	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	264	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	AAGCCGTCATCAGTGGCAAAC	0.627													A	46320342	A	A	46320342	3	1	146	1	0	0	0	0	1	0	0	0	7894	826	29	5	1559	5	ITGB2	21	46320342	Missense_Mutation	SNP	C	TCGA-15-0742-01A-01W-0348-08	59	46320342	1809553	80	10083											
INPP5J	27124	broad.mit.edu	37	chr22	31523945	31523945	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caccccaaacagcctcgtgtTctggttcggggacctgaact	10	14	1	1			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr22:31523945T>A	uc003aju.3	+	7	1888	c.1796T>A	c.(1795-1797)TTC>TAC	p.F599Y	INPP5J_uc003ajv.3_Missense_Mutation_p.F232Y|INPP5J_uc003ajs.3_Missense_Mutation_p.F232Y|INPP5J_uc011alk.1_Missense_Mutation_p.F532Y|INPP5J_uc010gwg.2_Missense_Mutation_p.F164Y|INPP5J_uc003ajw.2_Missense_Mutation_p.F35Y|INPP5J_uc003ajt.3_Missense_Mutation_p.F231Y|INPP5J_uc003ajx.2_5'UTR|INPP5J_uc003ajy.2_5'UTR|INPP5J_uc003ajz.2_5'UTR	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	599	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						AGCCTCGTGTTCTGGTTCGGG	0.577													A	31523945	A	A	31523945	3	1	146	1	0	0	0	0	1	0	0	0	7759	1783	62	5	718	5	INPP5J	22	31523945	Missense_Mutation	SNP	T	TCGA-15-0742-01A-01W-0348-08		31523945	19780621	81	10084											
DEPDC5	9681	broad.mit.edu	37	chr22	32239728	32239728	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gctgggtggaattctcccacGaacggctggaggagtacaag	15	9	1	0			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chr22:32239728G>T	uc003als.2	+	29	2846	c.2704G>T	c.(2704-2706)GAA>TAA	p.E902*	DEPDC5_uc011als.1_Nonsense_Mutation_p.E833*|DEPDC5_uc011alu.1_Nonsense_Mutation_p.E911*|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Nonsense_Mutation_p.E902*|DEPDC5_uc003alu.2_Nonsense_Mutation_p.E351*|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Nonsense_Mutation_p.E232*|DEPDC5_uc003alw.2_Nonsense_Mutation_p.E200*|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_5'Flank	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	902					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						ATTCTCCCACGAACGGCTGGA	0.498													T	32239728	T	T	32239728	4	4	146	1	0	0	0	0	0	1	0	0	4442	1059	37	5	2832	5	DEPDC5	22	32239728	Nonsense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	715783	32239728	19064838	82	10085											
MAGEB1	4112	broad.mit.edu	37	chrX	30269614	30269614	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccacgacttttagagcgcGttctagagccccattcagca	9	13	2	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chrX:30269614G>A	uc004dcc.2	+	4	1324	c.1004G>A	c.(1003-1005)CGT>CAT	p.R335H	MAGEB1_uc004dcd.2_Missense_Mutation_p.R335H|MAGEB1_uc004dce.2_Missense_Mutation_p.R335H	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	335											0						TTTAGAGCGCGTTCTAGAGCC	0.507													A	30269614	A	A	30269614	3	1	146	1	0	0	0	0	1	0	0	0	9172	1145	40	1	1006	1	MAGEB1	23	30269614	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08		30269614	125000946	83	10086											
GRIA3	2892	broad.mit.edu	37	chrX	122460032	122460032	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agcgatacttgattgactgcGaagtcgaaaggattaacaca	10	7	0	2			TCGA-15-0742-01A-01W-0348-08	TCGA-15-0742-10A-01W-0348-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c015456-02f0-4473-be25-b53166da41ea	141031c5-2359-4c57-8982-a1ea3c57d411	g.chrX:122460032G>A	uc004etq.3	+	5	957	c.664G>A	c.(664-666)GAA>AAA	p.E222K	GRIA3_uc004etr.3_Missense_Mutation_p.E222K|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.E206K	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	222	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GATTGACTGCGAAGTCGAAAG	0.423													A	122460032	A	A	122460032	3	1	146	1	0	0	0	0	1	0	0	0	6769	1059	37	2	678	2	GRIA3	23	122460032	Missense_Mutation	SNP	G	TCGA-15-0742-01A-01W-0348-08	92190418	122460032	32810528	84	10087											
MACF1	23499	broad.mit.edu	37	chr1	39761487	39761487	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctgctgtccagtcccagtTgcagtggatgaagcagctgt	13	10	0	1			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr1:39761487T>G	uc010ois.1	+	21	2508	c.2303T>G	c.(2302-2304)TTG>TGG	p.L768W	MACF1_uc001cda.1_Missense_Mutation_p.L676W	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	768					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGTCCCAGTTGCAGTGGATG	0.433													G	39761487	G	G	39761487	3	3	147	1	0	0	0	0	1	0	0	0	9144	1821	63	5	2377	5	MACF1	1	39761487	Missense_Mutation	SNP	T	TCGA-15-1444-01A-02D-1696-08		39761487	209489134	1	10088											
C1orf163	65260	broad.mit.edu	37	chr1	53158443	53158443	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagtttgtagcagctatcaCtgtgctggttctcttcacag	9	11	3	0			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr1:53158443C>T	uc001cui.1	-	2	243	c.203G>A	c.(202-204)AGT>AAT	p.S68N		NM_023077	NP_075565	Q96BR5	SELR1_HUMAN	hypothetical protein LOC65260	68	Sel1-like 2.						binding				0						GCAGCTATCACTGTGCTGGTT	0.502													T	53158443	T	T	53158443	3	4	147	1	0	0	0	0	1	0	0	0	2011	565	20	3	500	3	C1orf163	1	53158443	Missense_Mutation	SNP	C	TCGA-15-1444-01A-02D-1696-08	13396956	53158443	196092178	2	10089											
PRG4	10216	broad.mit.edu	37	chr1	186277611	186277614	+	Frame_Shift_Del	DEL	AGAA	-	-													acagctaaagacaagacaacAgaaagagacttacgtactac							TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr1:186277611_186277614delAGAA	uc001gru.3	+	7	2811_2814	c.2760_2763delAGAA	c.(2758-2763)ACAGAAfs	p.T920fs	PRG4_uc001grt.3_Frame_Shift_Del_p.T879fs|PRG4_uc009wyl.2_Frame_Shift_Del_p.T827fs|PRG4_uc009wym.2_Frame_Shift_Del_p.T786fs|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	920_921					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ACAAGACAACAGAAAGAGACTTAC	0.412													-	186277614	-	-	186277611	7	5	147	1	0	1	0	1	0	0	0	0	12481	175	7	0	2782	0	PRG4	1	186277611	Frame_Shift_Del	DEL	AGAA	TCGA-15-1444-01A-02D-1696-08	133119168	186277611	62973010	3	10090											
ALK	238	broad.mit.edu	37	chr2	29917797	29917797	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctcggaggggatgcggcGccaggaccagctctggttcc	15	14	1	0			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr2:29917797G>A	uc002rmy.2	-	3	1778	c.871C>T	c.(871-873)CGC>TGC	p.R291C		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	291	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GGGATGCGGCGCCAGGACCAG	0.602			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				A	29917797	A	A	29917797	3	1	147	1	0	0	0	0	1	0	0	0	525	1087	38	1	4099	1	ALK	2	29917797	Missense_Mutation	SNP	G	TCGA-15-1444-01A-02D-1696-08		29917797	213281576	4	10091											
SFTPB	6439	broad.mit.edu	37	chr2	85892915	85892915	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcatacagatgccgtttgaGtcctggggcacagcacaggg	14	10	0	2			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr2:85892915G>A	uc002sqh.2	-	5	402	c.396C>T	c.(394-396)GAC>GAT	p.D132D	SFTPB_uc002sqi.2_Silent_p.D144D|SFTPB_uc002sqj.2_Silent_p.D132D	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	132	Saposin B-type 1.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						TGCCGTTTGAGTCCTGGGGCA	0.642													A	85892915	A	A	85892915	2	1	147	1	0	0	0	0	0	0	0	1	14191	1020	36	3		3	SFTPB	2	85892915	Silent	SNP	G	TCGA-15-1444-01A-02D-1696-08	55975118	85892915	157306458	5	10092											
IDH1	3417	broad.mit.edu	37	chr2	209113113	209113113	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ttgatccccataagcatgacGacctatgatgataggtttta	8	8	0	4	rs121913499		TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr2:209113113G>C	uc002vcs.2	-	4	640	c.394C>G	c.(394-396)CGT>GGT	p.R132G	IDH1_uc002vct.2_Missense_Mutation_p.R132G|IDH1_uc002vcu.2_Missense_Mutation_p.R132G	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398			Mis		gliobastoma 								C	209113113	C	C	209113113	3	2	147	1	0	0	0	0	1	0	0	0	7494	1058	37	5	878	5	IDH1	2	209113113	Missense_Mutation	SNP	G	TCGA-15-1444-01A-02D-1696-08	123220198	209113113	34086260	6	10093											
DNAJC13	23317	broad.mit.edu	37	chr3	132198097	132198097	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gataaacttgaacgagatagGttgattctcttccttaacaa	7	7	1	3	rs61748099	byFrequency	TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr3:132198097G>A	uc003eor.2	+	25	2801	c.2736G>A	c.(2734-2736)AGG>AGA	p.R912R		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	912							heat shock protein binding			ovary(1)|breast(1)	2						AACGAGATAGGTTGATTCTCT	0.294													A	132198097	A	A	132198097	2	1	147	1	0	0	0	0	0	0	0	1	4632	1252	44	3		3	DNAJC13	3	132198097	Silent	SNP	G	TCGA-15-1444-01A-02D-1696-08		132198097	65824333	7	10094											
WDR1	9948	broad.mit.edu	37	chr4	10080542	10080542	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaattgccaccgtgtccccGccggggtgcactgccacaac	10	18	0	0			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr4:10080542G>A	uc003gmf.2	-	12	1651	c.1368C>T	c.(1366-1368)GGC>GGT	p.G456G	WDR1_uc003gmg.2_Silent_p.G316G|WDR1_uc010idm.2_RNA|hsa-mir-3138|MI0014161_5'Flank	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	456	WD 8.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CCGTGTCCCCGCCGGGGTGCA	0.592													A	10080542	A	A	10080542	2	1	147	1	0	0	0	0	0	0	0	1	17269	1074	38	1		1	WDR1	4	10080542	Silent	SNP	G	TCGA-15-1444-01A-02D-1696-08		10080542	181073734	8	10095											
FRYL	285527	broad.mit.edu	37	chr4	48621289	48621289	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgcagaaataaaagagcttAcctgctttagaacttcaact	6	8	1	3			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr4:48621289A>G	uc003gyh.1	-	7	1016	c.411_splice	c.e7+1	p.Q137_splice	FRYL_uc003gyk.2_Splice_Site_p.Q137_splice|FRYL_uc003gyl.1_Missense_Mutation_p.V189A	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AAAAGAGCTTACCTGCTTTAG	0.363													G	48621289	G	G	48621289	5	3	147	1	0	0	0	0	0	0	1	0	6064	405	14	4	8860	4	FRYL	4	48621289	Splice_Site	SNP	A	TCGA-15-1444-01A-02D-1696-08	38540747	48621289	142532987	9	10096											
NFKB1	4790	broad.mit.edu	37	chr4	103518775	103518775	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtgaagatgctgctggccGtccagcgccatctcactgct	11	14	1	2	rs139575566		TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr4:103518775G>A	uc011ceq.1	+	15	2058	c.1591G>A	c.(1591-1593)GTC>ATC	p.V531I	NFKB1_uc011cep.1_Missense_Mutation_p.V532I|NFKB1_uc011cer.1_Missense_Mutation_p.V351I	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	531	Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	GCTGCTGGCCGTCCAGCGCCA	0.522													A	103518775	A	A	103518775	3	1	147	1	0	0	0	0	1	0	0	0	10375	1145	40	1	1648	1	NFKB1	4	103518775	Missense_Mutation	SNP	G	TCGA-15-1444-01A-02D-1696-08	54897486	103518775	87635501	10	10097											
PIK3R1	5295	broad.mit.edu	37	chr5	67591098	67591109	+	In_Frame_Del	DEL	ACAGCATTAAAC	-	-													agaaattgacaaacgtatgaAcagcattaaaccagacctta							TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr5:67591098_67591109delACAGCATTAAAC	uc003jva.2	+	13	2251_2262	c.1691_1702delACAGCATTAAAC	c.(1690-1704)AACAGCATTAAACCA>ACA	p.564_568NSIKP>T	PIK3R1_uc003jvb.2_In_Frame_Del_p.564_568NSIKP>T|PIK3R1_uc003jvc.2_In_Frame_Del_p.264_268NSIKP>T|PIK3R1_uc003jvd.2_In_Frame_Del_p.294_298NSIKP>T|PIK3R1_uc003jve.2_In_Frame_Del_p.243_247NSIKP>T|PIK3R1_uc011crb.1_In_Frame_Del_p.234_238NSIKP>T	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	564_568					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.N564D(3)|p.D560_S565del(1)|p.N564K(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AAACGTATGAACAGCATTAAACCAGACCTTAT	0.373			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67591109	-	-	67591098	7	5	147	1	0	1	0	1	0	0	0	0	11918	43	2	0	1867	0	PIK3R1	5	67591098	In_Frame_Del	DEL	ACAGCATTAAAC	TCGA-15-1444-01A-02D-1696-08		67591098	113324162	11	10098											
GRINA	2907	broad.mit.edu	37	chr8	145065758	145065758	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agccacaggtcttcccaggaCaagaccctgactgtgagtct	10	13	2	3			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr8:145065758C>G	uc003zan.1	+	2	533	c.367C>G	c.(367-369)CAA>GAA	p.Q123E	GRINA_uc003zao.1_Missense_Mutation_p.Q123E|GRINA_uc003zap.1_Missense_Mutation_p.Q123E	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	123	Pro-rich.					integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTTCCCAGGACAAGACCCTGA	0.672													G	145065758	G	G	145065758	3	3	147	1	0	0	0	0	1	0	0	0	6785	479	17	5	369	5	GRINA	8	145065758	Missense_Mutation	SNP	C	TCGA-15-1444-01A-02D-1696-08		145065758	1298264	12	10099											
TYRP1	7306	broad.mit.edu	37	chr9	12702411	12702414	+	Frame_Shift_Del	DEL	ACAA	-	-													ctcctttttattccaactctAcaaacagtttccgaaacaca							TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr9:12702411_12702414delACAA	uc003zkv.3	+	5	1232_1235	c.1054_1057delACAA	c.(1054-1059)ACAAACfs	p.T352fs		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	352_353	Lumenal, melanosome (Potential).				melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		TTCCAACTCTACAAACAGTTTCCG	0.387									Oculocutaneous_Albinism				-	12702414	-	-	12702411	7	5	147	1	0	1	0	1	0	0	0	0	16813	391	14	0	1068	0	TYRP1	9	12702411	Frame_Shift_Del	DEL	ACAA	TCGA-15-1444-01A-02D-1696-08		12702411	128511020	13	10100											
ITIH2	3698	broad.mit.edu	37	chr10	7771922	7771922	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcaccaactttaggcgaactAaaactgtcaaaaattcagaa	5	9	3	1			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr10:7771922A>T	uc001ijs.2	+	12	1449	c.1287A>T	c.(1285-1287)CTA>CTT	p.L429L		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	429	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TAGGCGAACTAAAACTGTCAA	0.313													T	7771922	T	T	7771922	2	4	147	1	0	0	0	0	0	0	0	1	7904	349	13	5		5	ITIH2	10	7771922	Silent	SNP	A	TCGA-15-1444-01A-02D-1696-08		7771922	127762825	14	10101											
CLPB	81570	broad.mit.edu	37	chr11	72012979	72012979	+	Frame_Shift_Del	DEL	G	-	-													ccctcctcatggccaacgtaGcctggtggagacccaataaa							TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr11:72012979delG	uc001osj.2	-	12	1337	c.1287delC	c.(1285-1287)GGCfs	p.G429fs	CLPB_uc010rqx.1_Frame_Shift_Del_p.G384fs|CLPB_uc010rqy.1_Frame_Shift_Del_p.G370fs|CLPB_uc001osk.2_Frame_Shift_Del_p.G399fs|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Frame_Shift_Del_p.G228fs|CLPB_uc001osi.2_Frame_Shift_Del_p.G37fs	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	429					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						GGCCAACGTAGCCTGGTGGAG	0.522													-	72012979	-	-	72012979	7	5	147	1	0	1	0	1	0	0	0	0	3551	958	34	0	860	0	CLPB	11	72012979	Frame_Shift_Del	DEL	G	TCGA-15-1444-01A-02D-1696-08		72012979	62993537	15	10102											
HEPHL1	341208	broad.mit.edu	37	chr11	93844970	93844970	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctccttctaatcaccacGgtgattctctccctcagact	4	17	4	2	rs118037969	by1000genomes	TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr11:93844970G>A	uc001pep.2	+	20	3547	c.3390G>A	c.(3388-3390)ACG>ACA	p.T1130T	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	1130	Helical; (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TAATCACCACGGTGATTCTCT	0.507													A	93844970	A	A	93844970	2	1	147	1	0	0	0	0	0	0	0	1	7055	1103	39	2		2	HEPHL1	11	93844970	Silent	SNP	G	TCGA-15-1444-01A-02D-1696-08	21831991	93844970	41161546	16	10103											
AMN1	196394	broad.mit.edu	37	chr12	31850308	31850308	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaattacctctaatttcttcGcacaaggtccactaacaagt	4	11	2	0			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr12:31850308G>A	uc001rkq.3	-	5	744	c.578C>T	c.(577-579)GCG>GTG	p.A193V	AMN1_uc001rko.3_Missense_Mutation_p.A175V|AMN1_uc010skc.1_Missense_Mutation_p.A175V|AMN1_uc001rkp.3_Missense_Mutation_p.A175V|AMN1_uc009zjs.2_RNA|AMN1_uc009zjt.1_RNA	NM_001113402	NP_001106873	Q8IY45	AMN1_HUMAN	antagonist of mitotic exit network 1 homolog	193											0	all_cancers(9;7.41e-12)|all_epithelial(9;1.18e-11)|all_lung(12;1.14e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.162)		OV - Ovarian serous cystadenocarcinoma(6;0.0014)			TAATTTCTTCGCACAAGGTCC	0.338													A	31850308	A	A	31850308	3	1	147	1	0	0	0	0	1	0	0	0	581	1087	38	1	210	1	AMN1	12	31850308	Missense_Mutation	SNP	G	TCGA-15-1444-01A-02D-1696-08		31850308	102001587	17	10104											
MARCH9	92979	broad.mit.edu	37	chr12	58152585	58152585	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcctcagcgctgcggttatAcaatcttgcacctccttggg	10	13	2	0			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr12:58152585A>G	uc001spx.1	+	4	1358	c.946A>G	c.(946-948)ACA>GCA	p.T316A	MARCH9_uc001spy.2_Missense_Mutation_p.T203A	NM_138396	NP_612405	Q86YJ5	MARH9_HUMAN	membrane-associated RING-CH protein IX	316						Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding				0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CTGCGGTTATACAATCTTGCA	0.652													G	58152585	G	G	58152585	3	3	147	1	0	0	0	0	1	0	0	0	9308	391	14	4	960	4	MARCH9	12	58152585	Missense_Mutation	SNP	A	TCGA-15-1444-01A-02D-1696-08	26302277	58152585	75699310	18	10105											
PMFBP1	83449	broad.mit.edu	37	chr16	72184633	72184633	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctcctctctagagaggcgatCttgtccccggccaaggcgag	12	14	2	1			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr16:72184633C>T	uc002fcc.3	-	5	682	c.510G>A	c.(508-510)AAG>AAA	p.K170K	PMFBP1_uc002fcd.2_Silent_p.K170K|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Silent_p.K25K	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	170	Potential.									ovary(2)	2		Ovarian(137;0.179)				GAGAGGCGATCTTGTCCCCGG	0.498													T	72184633	T	T	72184633	2	4	147	1	0	0	0	0	0	0	0	1	12134	912	32	3		3	PMFBP1	16	72184633	Silent	SNP	C	TCGA-15-1444-01A-02D-1696-08		72184633	18170120	19	10106											
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	16	11	1	1	rs121912651		TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577539	A	A	7577539	3	1	147	1	0	0	0	0	1	0	0	0	16378	1115	39	2	548	2	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-15-1444-01A-02D-1696-08		7577539	73617671	20	10107											
BRIP1	83990	broad.mit.edu	37	chr17	59876469	59876469	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatcttcttacttaatgagGctacagcacacagctcgtag	7	10	2	1			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr17:59876469G>A	uc002izk.1	-	9	1473	c.1332C>T	c.(1330-1332)AGC>AGT	p.S444S		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	444					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						ACTTAATGAGGCTACAGCACA	0.358			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				A	59876469	A	A	59876469	2	1	147	1	0	0	0	0	0	0	0	1	1514	1194	42	3		3	BRIP1	17	59876469	Silent	SNP	G	TCGA-15-1444-01A-02D-1696-08	52298930	59876469	21318741	21	10108											
COLEC12	81035	broad.mit.edu	37	chr18	334801	334801	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ccaggggcaccaccgctcctGatgggccaggagggccgggg	18	14	0	1			TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chr18:334801G>A	uc002kkm.2	-	6	1972	c.1757C>T	c.(1756-1758)TCA>TTA	p.S586L		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	586	Collagen-like 3.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CACCGCTCCTGATGGGCCAGG	0.701													A	334801	A	A	334801	3	1	147	1	0	0	0	0	1	0	0	0	3712	1294	45	3	491	3	COLEC12	18	334801	Missense_Mutation	SNP	G	TCGA-15-1444-01A-02D-1696-08		334801	77742447	22	10109											
ATRX	546	broad.mit.edu	37	chrX	76814207	76814208	+	Frame_Shift_Del	DEL	TG	-	-													gataaactctgaatatactcTggatgtcataagatggattc							TCGA-15-1444-01A-02D-1696-08	TCGA-15-1444-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cbd4d4e7-f1c4-446c-8dbc-ce06c872ec14	41190f35-e3af-46e3-9b2d-41bc41d5891b	g.chrX:76814207_76814208delTG	uc004ecp.3	-	29	6668_6669	c.6436_6437delCA	c.(6436-6438)CAGfs	p.Q2146fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.Q2108fs|ATRX_uc004eco.3_Frame_Shift_Del_p.Q1931fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2146	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GAATATACTCTGGATGTCATAA	0.337			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						-	76814208	-	-	76814207	7	5	147	1	0	1	0	1	0	0	0	0	1208	1580	55	0	1069	0	ATRX	23	76814207	Frame_Shift_Del	DEL	TG	TCGA-15-1444-01A-02D-1696-08		76814207	78456353	23	10110											
SERINC2	347735	broad.mit.edu	37	chr1	31905860	31905860	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgaacagcctgatgcagaccGaggagtgcccacctatgcta	11	12	0	3	rs139208281	byFrequency	TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:31905860G>A	uc010ogh.1	+	9	1273	c.1072G>A	c.(1072-1074)GAG>AAG	p.E358K	SERINC2_uc010ogg.1_Missense_Mutation_p.E355K|SERINC2_uc001bst.2_Missense_Mutation_p.E354K|SERINC2_uc001bsu.2_Missense_Mutation_p.E299K|SERINC2_uc001bsv.2_Missense_Mutation_p.E299K	NM_178865	NP_849196	Q96SA4	SERC2_HUMAN	tumor differentially expressed 2-like	354						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)		GATGCAGACCGAGGAGTGCCC	0.617													A	31905860	A	A	31905860	3	1	148	1	0	0	0	0	1	0	0	0	14080	1059	37	2	1094	2	SERINC2	1	31905860	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08		31905860	217344761	1	10111											
ZC3H12A	80149	broad.mit.edu	37	chr1	37948876	37948876	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagccttctctgcctttggCcgggccatgggtgctggcca	14	14	1	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:37948876C>T	uc001cbb.3	+	6	1614	c.1464C>T	c.(1462-1464)GGC>GGT	p.G488G	ZC3H12A_uc001cbc.1_Silent_p.G283G	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	488	Pro-rich.				angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTGCCTTTGGCCGGGCCATGG	0.662													T	37948876	T	T	37948876	2	4	148	1	0	0	0	0	0	0	0	1	17558	726	26	3		3	ZC3H12A	1	37948876	Silent	SNP	C	TCGA-16-0846-01A-01W-0424-08	6043016	37948876	211301745	2	10112											
MFSD2A	84879	broad.mit.edu	37	chr1	40432533	40432533	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgcctacttccggggcctaCggctggtcatgagccacggc	13	15	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:40432533C>T	uc001cev.2	+	8	1076	c.895C>T	c.(895-897)CGG>TGG	p.R299W	MFSD2A_uc010ojb.1_Missense_Mutation_p.R247W|MFSD2A_uc001ceu.2_Missense_Mutation_p.R286W|MFSD2A_uc010ojc.1_Missense_Mutation_p.R130W|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_5'Flank	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	299					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						CCGGGGCCTACGGCTGGTCAT	0.572													T	40432533	T	T	40432533	3	4	148	1	0	0	0	0	1	0	0	0	9530	527	19	1	925	1	MFSD2A	1	40432533	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	2483657	40432533	208818088	3	10113											
FAM151A	338094	broad.mit.edu	37	chr1	55078368	55078368	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gccttgggatacttctcctgGaccagggccaggaacctgca	12	13	1	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:55078368G>T	uc001cxn.2	-	5	723	c.591C>A	c.(589-591)GTC>GTA	p.V197V	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	197						integral to membrane					0						ACTTCTCCTGGACCAGGGCCA	0.562													T	55078368	T	T	55078368	2	4	148	1	0	0	0	0	0	0	0	1	5458	1161	41	5		5	FAM151A	1	55078368	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	14645835	55078368	194172253	4	10114											
TM2D1	83941	broad.mit.edu	37	chr1	62190705	62190705	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aacagccccccagggtcctgTagtgactgagacgaaccaca	10	14	0	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:62190705T>A	uc001czz.1	-	1	391	c.88A>T	c.(88-90)ACA>TCA	p.T30S		NM_032027	NP_114416	Q9BX74	TM2D1_HUMAN	beta-amyloid binding protein precursor	30					apoptosis					ovary(1)	1						CAGGGTCCTGTAGTGACTGAG	0.647													A	62190705	A	A	62190705	3	1	148	1	0	0	0	0	1	0	0	0	15960	1638	57	5	559	5	TM2D1	1	62190705	Missense_Mutation	SNP	T	TCGA-16-0846-01A-01W-0424-08	7112337	62190705	187059916	5	10115											
HRNR	388697	broad.mit.edu	37	chr1	152193139	152193139	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagccagacccgtgttggccGtggctggaggagtgccccga	17	12	0	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:152193139G>A	uc001ezt.1	-	3	1042	c.966C>T	c.(964-966)CAC>CAT	p.H322H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	322	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTGTTGGCCGTGGCTGGAGG	0.607													A	152193139	A	A	152193139	2	1	148	1	0	0	0	0	0	0	0	1	7359	1136	40	1		1	HRNR	1	152193139	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	90002434	152193139	97057482	6	10116											
YY1AP1	55249	broad.mit.edu	37	chr1	155629971	155629971	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tctgggccacagccgcattgAcaggctggatcatgttacag	12	11	2	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:155629971A>T	uc001fln.2	-	11	1892	c.1868T>A	c.(1867-1869)GTC>GAC	p.V623D	YY1AP1_uc001flg.2_Missense_Mutation_p.V362D|YY1AP1_uc010pgg.1_Missense_Mutation_p.V462D|YY1AP1_uc010pgh.1_Missense_Mutation_p.V566D|YY1AP1_uc010pgi.1_Missense_Mutation_p.V715D|YY1AP1_uc001flh.2_Missense_Mutation_p.V695D|YY1AP1_uc009wqt.2_Missense_Mutation_p.V546D|YY1AP1_uc001flk.2_Missense_Mutation_p.V566D|YY1AP1_uc001fll.2_Missense_Mutation_p.V577D|YY1AP1_uc009wqv.2_Missense_Mutation_p.V294D|YY1AP1_uc001flm.2_Missense_Mutation_p.V566D|YY1AP1_uc001fli.2_Missense_Mutation_p.V577D|YY1AP1_uc009wqu.2_Missense_Mutation_p.V410D|YY1AP1_uc001flj.2_Missense_Mutation_p.V557D|YY1AP1_uc009wqw.2_Missense_Mutation_p.V546D|YY1AP1_uc001flo.2_Missense_Mutation_p.V511D|YY1AP1_uc001flp.2_Missense_Mutation_p.V577D	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	623					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					AGCCGCATTGACAGGCTGGAT	0.557													T	155629971	T	T	155629971	3	4	148	1	0	0	0	0	1	0	0	0	17505	275	10	5	526	5	YY1AP1	1	155629971	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08	3436832	155629971	93620650	7	10117											
OLFML2B	25903	broad.mit.edu	37	chr1	161987297	161987297	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgtctatgattgtggagaGctatgaaacaaggcaagggg	14	5	1	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:161987297G>A	uc001gbu.2	-	3	863	c.439C>T	c.(439-441)CTC>TTC	p.L147F	OLFML2B_uc010pkq.1_Missense_Mutation_p.L147F	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	147										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			ATTGTGGAGAGCTATGAAACA	0.522													A	161987297	A	A	161987297	3	1	148	1	0	0	0	0	1	0	0	0	10858	985	34	3	1837	3	OLFML2B	1	161987297	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	6357326	161987297	87263324	8	10118											
LGR6	59352	broad.mit.edu	37	chr1	202249926	202249926	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggcatttgcataacaaccGcatccagcatctggggaccc	9	14	1	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:202249926G>A	uc001gxu.2	+	6	662	c.662G>A	c.(661-663)CGC>CAC	p.R221H	LGR6_uc001gxv.2_Missense_Mutation_p.R169H|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Intron|LGR6_uc009xac.1_RNA	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	221	LRR 6.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						CATAACAACCGCATCCAGCAT	0.567													A	202249926	A	A	202249926	3	1	148	1	0	0	0	0	1	0	0	0	8758	1087	38	1	831	1	LGR6	1	202249926	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	40262629	202249926	47000695	9	10119											
LAMB3	3914	broad.mit.edu	37	chr1	209797264	209797264	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggagaccattgaagcttctGtcaagactctccaggtctct	9	11	4	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr1:209797264G>A	uc001hhg.2	-	14	2448	c.2058C>T	c.(2056-2058)GAC>GAT	p.D686D	LAMB3_uc009xco.2_Silent_p.D686D|LAMB3_uc001hhh.2_Silent_p.D686D|LAMB3_uc010psl.1_RNA|hsa-mir-4260|MI0015859_5'Flank	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	686	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TGAAGCTTCTGTCAAGACTCT	0.547													A	209797264	A	A	209797264	2	1	148	1	0	0	0	0	0	0	0	1	8612	1368	48	3		3	LAMB3	1	209797264	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	7547338	209797264	39453357	10	10120											
BCL11A	53335	broad.mit.edu	37	chr2	60688453	60688453	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgcccacgcccacgaccgCgccccgcgagctgttctcgt	11	20	1	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr2:60688453C>T	uc002sae.1	-	4	1822	c.1594G>A	c.(1594-1596)GCG>ACG	p.A532T	BCL11A_uc002sab.2_Missense_Mutation_p.A532T|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.A201T|BCL11A_uc010ypj.1_Missense_Mutation_p.A498T|BCL11A_uc002sad.1_Missense_Mutation_p.A380T|BCL11A_uc002saf.1_Missense_Mutation_p.A498T	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	532					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CCCACGACCGCGCCCCGCGAG	0.637			T	IGH@	B-CLL								T	60688453	T	T	60688453	3	4	148	1	0	0	0	0	1	0	0	0	1363	768	27	1	1023	1	BCL11A	2	60688453	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08		60688453	182510920	11	10121											
MYO7B	4648	broad.mit.edu	37	chr2	128370138	128370138	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtccaacctggagaaggtgCacttcatcgtgggctacgcc	12	12	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr2:128370138C>T	uc002top.2	+	25	3333	c.3280C>T	c.(3280-3282)CAC>TAC	p.H1094Y		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1094	MyTH4 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GGAGAAGGTGCACTTCATCGT	0.602													T	128370138	T	T	128370138	3	4	148	1	0	0	0	0	1	0	0	0	10083	710	25	3	3374	3	MYO7B	2	128370138	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	67681685	128370138	114829235	12	10122											
SCN9A	6335	broad.mit.edu	37	chr2	167056246	167056246	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagggacatcatcaaagcaaAgagcagcgtgcggatcccct	11	11	2	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr2:167056246A>T	uc010fpl.2	-	27	5211	c.4870T>A	c.(4870-4872)TTT>ATT	p.F1624I	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1635	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ATCAAAGCAAAGAGCAGCGTG	0.507													T	167056246	T	T	167056246	3	4	148	1	0	0	0	0	1	0	0	0	13925	72	3	5	1067	5	SCN9A	2	167056246	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08	38686108	167056246	76143127	13	10123											
HOXD4	3233	broad.mit.edu	37	chr2	177017342	177017342	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttttgtctcgcagtgaaccCcaactacaccggtggggaac	11	12	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr2:177017342C>T	uc002uks.2	+	2	689	c.440C>T	c.(439-441)CCC>CTC	p.P147L		NM_014621	NP_055436	P09016	HXD4_HUMAN	homeobox D4	147						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		GCAGTGAACCCCAACTACACC	0.527													T	177017342	T	T	177017342	3	4	148	1	0	0	0	0	1	0	0	0	7324	623	22	3	446	3	HOXD4	2	177017342	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	9961096	177017342	66182031	14	10124											
COL3A1	1281	broad.mit.edu	37	chr2	189858803	189858803	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtagtcctggtggtaaaggcGaaatggtaagctgtccccac	13	9	0	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr2:189858803G>A	uc002uqj.1	+	17	1306	c.1189G>A	c.(1189-1191)GAA>AAA	p.E397K	COL3A1_uc010frw.1_RNA	NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	397	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGGTAAAGGCGAAATGGTAAG	0.373													A	189858803	A	A	189858803	3	1	148	1	0	0	0	0	1	0	0	0	3688	1059	37	2	1255	2	COL3A1	2	189858803	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	12841461	189858803	53340570	15	10125											
PRKAG3	53632	broad.mit.edu	37	chr2	219689035	219689035	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agacatagtgtcctctgcctCagggcttctcccacactcat	7	15	4	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr2:219689035C>T	uc002vjb.1	-	12	1282	c.1263G>A	c.(1261-1263)CTG>CTA	p.L421L		NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	421					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCTCTGCCTCAGGGCTTCTC	0.597													T	219689035	T	T	219689035	2	4	148	1	0	0	0	0	0	0	0	1	12502	813	29	3		3	PRKAG3	2	219689035	Silent	SNP	C	TCGA-16-0846-01A-01W-0424-08	29830232	219689035	23510338	16	10126											
GRM7	2917	broad.mit.edu	37	chr3	6903256	6903256	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgttccccgtgcacgccaagGgtcccagcggagtgccctgc	13	16	0	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr3:6903256G>T	uc003bqm.2	+	1	455	c.181G>T	c.(181-183)GGT>TGT	p.G61C	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.G61C|GRM7_uc003bql.2_Missense_Mutation_p.G61C	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	61	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GCACGCCAAGGGTCCCAGCGG	0.672													T	6903256	T	T	6903256	3	4	148	1	0	0	0	0	1	0	0	0	6802	1232	43	5	183	5	GRM7	3	6903256	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08		6903256	191119174	17	10127											
CD38	952	broad.mit.edu	37	chr4	15835885	15835885	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctggagaaaggactgcagcaAcaaccctgtttcagtattct	9	10	2	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr4:15835885A>G	uc011bxc.1	+	4	652	c.545A>G	c.(544-546)AAC>AGC	p.N182S	CD38_uc003gol.1_Missense_Mutation_p.N182S	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	182	Extracellular (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						GACTGCAGCAACAACCCTGTT	0.388													G	15835885	G	G	15835885	3	3	148	1	0	0	0	0	1	0	0	0	3009	43	2	4	559	4	CD38	4	15835885	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08		15835885	175318391	18	10128											
GALNT7	51809	broad.mit.edu	37	chr4	174219326	174219326	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacacatatgaaattataccCcaagggggtggtgatgaaga	11	6	0	4			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr4:174219326C>T	uc003isz.3	+	6	1109	c.1026C>T	c.(1024-1026)CCC>CCT	p.P342P	GALNT7_uc011ckb.1_Intron	NM_017423	NP_059119	Q86SF2	GALT7_HUMAN	polypeptide N-acetylgalactosaminyltransferase 7	342	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		AAATTATACCCCAAGGGGGTG	0.473													T	174219326	T	T	174219326	2	4	148	1	0	0	0	0	0	0	0	1	6218	610	22	3		3	GALNT7	4	174219326	Silent	SNP	C	TCGA-16-0846-01A-01W-0424-08	158383441	174219326	16934950	19	10129											
C9	735	broad.mit.edu	37	chr5	39316092	39316092	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tttaaatgcttcaatttgttCttcgtaatgttcggttctga	7	6	3	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr5:39316092C>G	uc003jlv.3	-	6	744	c.655G>C	c.(655-657)GAA>CAA	p.E219Q		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	219	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			TCAATTTGTTCTTCGTAATGT	0.303													G	39316092	G	G	39316092	3	3	148	1	0	0	0	0	1	0	0	0	2443	922	32	5	1048	5	C9	5	39316092	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08		39316092	141599168	20	10130											
HEATR7B2	133558	broad.mit.edu	37	chr5	41061824	41061824	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggctttgctgaatttctcaaGggctgcatttaaaacacaca	8	9	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr5:41061824G>T	uc003jmj.3	-	6	953	c.463C>A	c.(463-465)CTT>ATT	p.L155I		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	155							binding			ovary(6)|central_nervous_system(2)	8						AATTTCTCAAGGGCTGCATTT	0.398													T	41061824	T	T	41061824	3	4	148	1	0	0	0	0	1	0	0	0	7035	1000	35	5	4442	5	HEATR7B2	5	41061824	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	1745732	41061824	139853436	21	10131											
POLR3G	10622	broad.mit.edu	37	chr5	89802453	89802453	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgacgatgacgatgatgccGcagaacaggaggaatatgat	13	6	0	5			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr5:89802453G>A	uc003kjq.2	+	7	747	c.547G>A	c.(547-549)GCA>ACA	p.A183T	POLR3G_uc011cuc.1_Missense_Mutation_p.A183T	NM_006467	NP_006458	O15318	RPC7_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	183	Glu-rich.				innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA-directed RNA polymerase activity				0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;2.74e-31)|Epithelial(54;8.2e-26)|all cancers(79;3.86e-22)		cgatgatgccgcagaacagga	0.09													A	89802453	A	A	89802453	3	1	148	1	0	0	0	0	1	0	0	0	12234	1087	38	1	569	1	POLR3G	5	89802453	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	48740629	89802453	91112807	22	10132											
C5orf46	389336	broad.mit.edu	37	chr5	147286057	147286057	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcaggcgaagtactgagAcagccattctggtagcacgg	13	10	2	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr5:147286057A>C	uc010jgp.2	-	1	45	c.8T>G	c.(7-9)GTC>GGC	p.V3G	C5orf46_uc003lou.2_Missense_Mutation_p.V3G|C5orf46_uc003lov.3_Missense_Mutation_p.V3G	NM_206966	NP_996849	Q6UWT4	CE046_HUMAN	hypothetical protein LOC389336 precursor	3						extracellular region					0						AAGTACTGAGACAGCCATTCT	0.453													C	147286057	C	C	147286057	3	2	148	1	0	0	0	0	1	0	0	0	2305	275	10	5	267	5	C5orf46	5	147286057	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08	57483604	147286057	33629203	23	10133											
SH3TC2	79628	broad.mit.edu	37	chr5	148427540	148427540	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	agcggctctttacacagaagGagagtgtcaggtcttaaaga	12	7	3	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr5:148427540G>C	uc003lpu.2	-	3	316	c.164C>G	c.(163-165)TCC>TGC	p.S55C	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Missense_Mutation_p.S55C|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_5'UTR|SH3TC2_uc003lpw.1_Missense_Mutation_p.S55C	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	55							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACACAGAAGGAGAGTGTCAG	0.498													C	148427540	C	C	148427540	3	2	148	1	0	0	0	0	1	0	0	0	14262	1174	41	5	3762	5	SH3TC2	5	148427540	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	1141483	148427540	32487720	24	10134											
KIAA0319	9856	broad.mit.edu	37	chr6	24563628	24563628	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcttctggaccttaatgtcCgagtccagcacgttcagcag	9	12	3	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr6:24563628C>T	uc011djo.1	-	16	2787	c.2550G>A	c.(2548-2550)TCG>TCA	p.S850S	KIAA0319_uc011djp.1_Silent_p.S805S|KIAA0319_uc003neh.1_Silent_p.S850S|KIAA0319_uc011djq.1_Silent_p.S841S|KIAA0319_uc011djr.1_Silent_p.S850S|KIAA0319_uc010jpt.1_Silent_p.S261S	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	850	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CCTTAATGTCCGAGTCCAGCA	0.587													T	24563628	T	T	24563628	2	4	148	1	0	0	0	0	0	0	0	1	8168	639	23	2		2	KIAA0319	6	24563628	Silent	SNP	C	TCGA-16-0846-01A-01W-0424-08		24563628	146551439	25	10135											
PHACTR2	9749	broad.mit.edu	37	chr6	144033221	144033221	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caggttcccaaacacctcccTtcaaaagaaaggggaaacta	7	12	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr6:144033221T>C	uc003qjq.3	+	2	212	c.82T>C	c.(82-84)TTC>CTC	p.F28L	PHACTR2_uc010khh.2_Missense_Mutation_p.F28L|PHACTR2_uc010khi.2_Missense_Mutation_p.F39L|PHACTR2_uc003qjr.3_Missense_Mutation_p.F39L	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	28							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		AACACCTCCCTTCAAAAGAAA	0.433													C	144033221	C	C	144033221	3	2	148	1	0	0	0	0	1	0	0	0	11810	1609	56	4	138	4	PHACTR2	6	144033221	Missense_Mutation	SNP	T	TCGA-16-0846-01A-01W-0424-08	119469593	144033221	27081846	26	10136											
SDK1	221935	broad.mit.edu	37	chr7	4213951	4213951	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcaggcactgaggccaagaCgctcaaaaaccctatagctt	9	12	2	2	rs140602039		TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr7:4213951C>T	uc003smx.2	+	33	5037	c.4898C>T	c.(4897-4899)ACG>ATG	p.T1633M	SDK1_uc010kso.2_Missense_Mutation_p.T909M|SDK1_uc003smy.2_Missense_Mutation_p.T120M	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1633	Fibronectin type-III 10.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GAGGCCAAGACGCTCAAAAAC	0.562													T	4213951	T	T	4213951	3	4	148	1	0	0	0	0	1	0	0	0	13968	536	19	1	5028	1	SDK1	7	4213951	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08		4213951	154924712	27	10137											
CPVL	54504	broad.mit.edu	37	chr7	29160576	29160576	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtcctgagtctcccttaggTggcatggaaacacttctgta	10	10	2	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr7:29160576T>C	uc003szv.2	-	2	221	c.102A>G	c.(100-102)CCA>CCG	p.P34P	CPVL_uc003szw.2_Silent_p.P34P|CPVL_uc003szx.2_Silent_p.P34P	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	34					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						CTCCCTTAGGTGGCATGGAAA	0.468													C	29160576	C	C	29160576	2	2	148	1	0	0	0	0	0	0	0	1	3835	1683	59	4		4	CPVL	7	29160576	Silent	SNP	T	TCGA-16-0846-01A-01W-0424-08	24946625	29160576	129978087	28	10138											
AEBP1	165	broad.mit.edu	37	chr7	44148536	44148536	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcctccgccccagaagcccGatgctgagcgccagacagac	10	18	0	4			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr7:44148536G>A	uc003tkb.2	+	7	1284	c.979G>A	c.(979-981)GAT>AAT	p.D327N	AEBP1_uc003tkc.3_5'Flank|AEBP1_uc003tkd.2_5'Flank	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	327					cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCAGAAGCCCGATGCTGAGCG	0.652													A	44148536	A	A	44148536	3	1	148	1	0	0	0	0	1	0	0	0	349	1058	37	2	1005	2	AEBP1	7	44148536	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	14987960	44148536	114990127	29	10139											
ZNF680	340252	broad.mit.edu	37	chr7	64004099	64004099	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acctacctgggggtttggctAccatctcctgtctcttccta	8	14	2	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr7:64004099A>G	uc003tta.2	-	3	412	c.239T>C	c.(238-240)GTA>GCA	p.V80A	ZNF680_uc010kzr.2_Intron|ZNF680_uc003ttb.2_Missense_Mutation_p.V80A	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	80	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				GGGTTTGGCTACCATCTCCTG	0.428													G	64004099	G	G	64004099	3	3	148	1	0	0	0	0	1	0	0	0	18084	391	14	4	1484	4	ZNF680	7	64004099	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08	19855563	64004099	95134564	30	10140											
ZAN	7455	broad.mit.edu	37	chr7	100377161	100377161	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggccgacctccgcagggcGcgggaaaagtgcgaggcagc	18	13	0	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr7:100377161G>A	uc003uwj.2	+	36	6576	c.6411G>A	c.(6409-6411)GCG>GCA	p.A2137A	ZAN_uc003uwk.2_Silent_p.A2137A|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Silent_p.A224A	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2137	Extracellular (Potential).|VWFD 3.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TCCGCAGGGCGCGGGAAAAGT	0.637													A	100377161	A	A	100377161	2	1	148	1	0	0	0	0	0	0	0	1	17510	1074	38	1		1	ZAN	7	100377161	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	36373062	100377161	58761502	31	10141											
MUC17	140453	broad.mit.edu	37	chr7	100674926	100674926	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtacaacatctacaaatgtcGtggagccaagaatgtatttg	9	7	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr7:100674926G>A	uc003uxp.1	+	3	282	c.229G>A	c.(229-231)GTG>ATG	p.V77M	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	77	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACAAATGTCGTGGAGCCAAG	0.448													A	100674926	A	A	100674926	3	1	148	1	0	0	0	0	1	0	0	0	9974	1145	40	1	239	1	MUC17	7	100674926	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	297765	100674926	58463737	32	10142											
RELN	5649	broad.mit.edu	37	chr7	103124180	103124180	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgacatgccaggtgatcccGttgttgacgctgtattgcag	12	9	0	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr7:103124180G>A	uc003vca.2	-	62	10261	c.10101C>T	c.(10099-10101)AAC>AAT	p.N3367N	RELN_uc010liz.2_Silent_p.N3367N	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3367	BNR 16.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGGTGATCCCGTTGTTGACGC	0.552													A	103124180	A	A	103124180	2	1	148	1	0	0	0	0	0	0	0	1	13220	1136	40	1		1	RELN	7	103124180	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	2449254	103124180	56014483	33	10143											
PUS7	54517	broad.mit.edu	37	chr7	105111170	105111170	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gactatattcttcattccatAttttgaaagtcctcgaagca	5	9	2	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr7:105111170A>C	uc003vcx.2	-	11	1582	c.1363T>G	c.(1363-1365)TAT>GAT	p.Y455D	PUS7_uc010lji.2_Missense_Mutation_p.Y461D|PUS7_uc003vcy.2_Missense_Mutation_p.Y455D|PUS7_uc003vcz.1_Missense_Mutation_p.Y455D	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	455	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						TTCATTCCATATTTTGAAAGT	0.423													C	105111170	C	C	105111170	3	2	148	1	0	0	0	0	1	0	0	0	12833	449	16	5	646	5	PUS7	7	105111170	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08	1986990	105111170	54027493	34	10144											
GIMAP7	168537	broad.mit.edu	37	chr7	150217096	150217096	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaccgctccctgaggatcGttctggtagggaaaactgga	14	9	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr7:150217096G>A	uc003whk.2	+	2	164	c.34G>A	c.(34-36)GTT>ATT	p.V12I		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	12							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTGAGGATCGTTCTGGTAGG	0.498													A	150217096	A	A	150217096	3	1	148	1	0	0	0	0	1	0	0	0	6384	1145	40	1	36	1	GIMAP7	7	150217096	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	45105926	150217096	8921567	35	10145											
INTS9	55756	broad.mit.edu	37	chr8	28627526	28627526	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttcttcccgctcgtgggctgGgcgggccgaggagggggcta	19	11	1	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr8:28627526G>T	uc003xha.2	-	16	1979	c.1680C>A	c.(1678-1680)GCC>GCA	p.A560A	INTS9_uc011lav.1_Silent_p.A536A|INTS9_uc011law.1_Silent_p.A539A|INTS9_uc011lax.1_Silent_p.A453A|INTS9_uc010lvc.2_RNA	NM_018250	NP_060720	Q9NV88	INT9_HUMAN	integrator complex subunit 9 isoform 1	560					snRNA processing	integrator complex	protein binding			central_nervous_system(1)|pancreas(1)	2		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		TCGTGGGCTGGGCGGGCCGAG	0.602											OREG0018682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	28627526	T	T	28627526	2	4	148	1	0	0	0	0	0	0	0	1	7785	1219	43	5		5	INTS9	8	28627526	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08		28627526	117736496	36	10146											
PRKDC	5591	broad.mit.edu	37	chr8	48772255	48772255	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tccggttgagaaatcaaattGactcatttcctcactcaggg	8	10	4	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr8:48772255G>A	uc003xqi.2	-	47	6181	c.6124C>T	c.(6124-6126)CAA>TAA	p.Q2042*	PRKDC_uc003xqj.2_Nonsense_Mutation_p.Q2042*|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2042					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AAATCAAATTGACTCATTTCC	0.423								NHEJ					A	48772255	A	A	48772255	4	1	148	1	0	0	0	0	0	1	0	0	12521	1299	45	3	6426	3	PRKDC	8	48772255	Nonsense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	20144729	48772255	97591767	37	10147											
RP1	6101	broad.mit.edu	37	chr8	55540932	55540932	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgaagaattaatccaagaagAggtagaggctagtaaaactt	10	4	0	5			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr8:55540932A>T	uc003xsd.1	+	4	4638	c.4490A>T	c.(4489-4491)GAG>GTG	p.E1497V	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1497					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.E1497E(1)		skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATCCAAGAAGAGGTAGAGGCT	0.313													T	55540932	T	T	55540932	3	4	148	1	0	0	0	0	1	0	0	0	13532	304	11	5	4500	5	RP1	8	55540932	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08	6768677	55540932	90823090	38	10148											
TRPA1	8989	broad.mit.edu	37	chr8	72973980	72973980	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtggcagcaaaatgaatgGctgtgcaccttcccttctgt	12	10	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr8:72973980G>A	uc003xza.2	-	7	999	c.824C>T	c.(823-825)GCC>GTC	p.A275V		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	275	Cytoplasmic (Potential).|ANK 7.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	AAAATGAATGGCTGTGCACCT	0.393													A	72973980	A	A	72973980	3	1	148	1	0	0	0	0	1	0	0	0	16574	1203	42	3	2619	3	TRPA1	8	72973980	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	17433048	72973980	73390042	39	10149											
MAPK15	225689	broad.mit.edu	37	chr8	144801307	144801307	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctggtaccgagcaccggagGtgctgctctcttcgcaccgg	14	14	1	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr8:144801307G>T	uc003yzj.2	+	6	603	c.562G>T	c.(562-564)GTG>TTG	p.V188L		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	188	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AGCACCGGAGGTGCTGCTCTC	0.687													T	144801307	T	T	144801307	3	4	148	1	0	0	0	0	1	0	0	0	9277	1261	44	5	584	5	MAPK15	8	144801307	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	71827327	144801307	1562715	40	10150											
NCBP1	4686	broad.mit.edu	37	chr9	100433448	100433448	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttagaccctcatatcttggcCgtgttccagcagttctgtgc	9	12	3	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr9:100433448C>T	uc004axq.2	+	23	2799	c.2340C>T	c.(2338-2340)GCC>GCT	p.A780A		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	780					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				ATATCTTGGCCGTGTTCCAGC	0.423													T	100433448	T	T	100433448	2	4	148	1	0	0	0	0	0	0	0	1	10211	639	23	2		2	NCBP1	9	100433448	Silent	SNP	C	TCGA-16-0846-01A-01W-0424-08		100433448	40779983	41	10151											
VDAC2	7417	broad.mit.edu	37	chr10	76970926	76970926	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggcctcgccatggcgaccCacggacagacttgcgcgcgt	14	16	0	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr10:76970926C>T	uc001jwz.2	+	2	169	c.10C>T	c.(10-12)CAC>TAC	p.H4Y	VDAC2_uc010qld.1_5'UTR|VDAC2_uc001jxa.2_5'UTR|VDAC2_uc010qle.1_5'UTR	NM_003375	NP_003366	P45880	VDAC2_HUMAN	voltage-dependent anion channel 2	4						mitochondrial nucleoid|mitochondrial outer membrane|pore complex	nucleotide binding|porin activity|protein binding|voltage-gated anion channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)				Dihydroxyaluminium(DB01375)	CATGGCGACCCACGGACAGAC	0.627													T	76970926	T	T	76970926	3	4	148	1	0	0	0	0	1	0	0	0	17144	594	21	3	12	3	VDAC2	10	76970926	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08		76970926	58563821	42	10152											
PTEN	5728	broad.mit.edu	37	chr10	89690846	89690846	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccgccaaatttaattgcagaGgtaggtatgaatgtactgta	10	6	0	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr10:89690846G>T	uc001kfb.2	+	5	1284	c.253G>T	c.(253-255)GTT>TTT	p.V85F		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	85	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(3)|p.V85A(2)|p.C71fs*6(2)|p.L70fs*7(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.V85G(1)|p.N82_P95del(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TAATTGCAGAGGTAGGTATGA	0.318		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89690846	T	T	89690846	3	4	148	1	0	0	0	0	1	0	0	0	12738	1014	35	5	267	5	PTEN	10	89690846	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	12719920	89690846	45843901	43	10153											
SEC23IP	11196	broad.mit.edu	37	chr10	121668628	121668628	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caagtggagagacaattgttAtgcacaatccaaaggtaatg	10	6	0	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr10:121668628A>G	uc001leu.1	+	5	1249	c.1177A>G	c.(1177-1179)ATG>GTG	p.M393V	SEC23IP_uc010qtc.1_Missense_Mutation_p.M182V	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	393					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		GACAATTGTTATGCACAATCC	0.303													G	121668628	G	G	121668628	3	3	148	1	0	0	0	0	1	0	0	0	13993	449	16	4	1195	4	SEC23IP	10	121668628	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08	31977782	121668628	13866119	44	10154											
TH	7054	broad.mit.edu	37	chr11	2186970	2186970	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgttctgcttacacagcccGaactccaccgtgaaccagta	7	16	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr11:2186970G>A	uc001lvq.2	-	12	1240	c.1221C>T	c.(1219-1221)TTC>TTT	p.F407F	TH_uc001lvp.2_Silent_p.F403F|TH_uc001lvr.2_Silent_p.F376F|TH_uc010qxj.1_Silent_p.F380F|TH_uc001lvs.2_Silent_p.F282F|TH_uc001lvt.2_Silent_p.F286F|TH_uc009ydh.1_RNA	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	407					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	TACACAGCCCGAACTCCACCG	0.667													A	2186970	A	A	2186970	2	1	148	1	0	0	0	0	0	0	0	1	15835	1049	37	2		2	TH	11	2186970	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08		2186970	132819546	45	10155											
OR51A4	401666	broad.mit.edu	37	chr11	4967921	4967921	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caactctgacagttgtcaggAttgaggtgtatctcagaggg	13	7	3	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr11:4967921A>G	uc010qys.1	-	1	410	c.410T>C	c.(409-411)ATC>ACC	p.I137T		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTTGTCAGGATTGAGGTGTA	0.428													G	4967921	G	G	4967921	3	3	148	1	0	0	0	0	1	0	0	0	11087	333	12	4	533	4	OR51A4	11	4967921	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08	2780951	4967921	130038595	46	10156											
NAV2	89797	broad.mit.edu	37	chr11	19961278	19961278	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgagcgtggagcccagccActtcaccaagactggacagc	12	13	1	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr11:19961278A>G	uc010rdm.1	+	9	2535	c.2174A>G	c.(2173-2175)CAC>CGC	p.H725R	NAV2_uc001mpp.2_Missense_Mutation_p.H638R|NAV2_uc001mpr.3_Missense_Mutation_p.H702R	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	725						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GAGCCCAGCCACTTCACCAAG	0.532													G	19961278	G	G	19961278	3	3	148	1	0	0	0	0	1	0	0	0	10184	159	6	4	2214	4	NAV2	11	19961278	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08	14993357	19961278	115045238	47	10157											
SPRYD5	84767	broad.mit.edu	37	chr11	55655591	55655591	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	catgaagaagagcaacatcaCttggaaaggctgcgaaagga	12	7	1	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr11:55655591C>A	uc010rip.1	+	4	683	c.591C>A	c.(589-591)CAC>CAA	p.H197Q	SPRYD5_uc010riq.1_Missense_Mutation_p.H54Q	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	197						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				AGCAACATCACTTGGAAAGGC	0.423													A	55655591	A	A	55655591	3	1	148	1	0	0	0	0	1	0	0	0	15110	564	20	5	601	5	SPRYD5	11	55655591	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	35694313	55655591	79350925	48	10158											
BIN2	51411	broad.mit.edu	37	chr12	51696870	51696870	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcccatgctgcattgcccaCctttgactgcactaaggaag	8	14	0	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr12:51696870C>T	uc001ryg.2	-	3	269	c.217_splice	c.e3+1	p.V73_splice	BIN2_uc009zlz.2_Splice_Site_p.V73_splice|BIN2_uc001ryh.2_Splice_Site|BIN2_uc010sng.1_Splice_Site_p.V47_splice	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2							cytoplasm	protein binding			ovary(1)	1						GCATTGCCCACCTTTGACTGC	0.433													T	51696870	T	T	51696870	5	4	148	1	0	0	0	0	0	0	1	0	1433	521	18	3	1523	3	BIN2	12	51696870	Splice_Site	SNP	C	TCGA-16-0846-01A-01W-0424-08		51696870	82155025	49	10159											
OR6C75	390323	broad.mit.edu	37	chr12	55759400	55759400	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gcagttggatttctgtgcctCcaatgtaattgatcatttta	8	7	2	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr12:55759400C>G	uc010spk.1	+	1	506	c.506C>G	c.(505-507)TCC>TGC	p.S169C		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						TTCTGTGCCTCCAATGTAATT	0.433													G	55759400	G	G	55759400	3	3	148	1	0	0	0	0	1	0	0	0	11199	855	30	5	508	5	OR6C75	12	55759400	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	4062530	55759400	78092495	50	10160											
FGD6	55785	broad.mit.edu	37	chr12	95604181	95604181	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaccaaggtctttgacttcTgatttcttactaactccatc	6	11	3	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr12:95604181T>C	uc001tdp.3	-	2	1103	c.879A>G	c.(877-879)TCA>TCG	p.S293S	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	293					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						CTTTGACTTCTGATTTCTTAC	0.388													C	95604181	C	C	95604181	2	2	148	1	0	0	0	0	0	0	0	1	5837	1567	55	4		4	FGD6	12	95604181	Silent	SNP	T	TCGA-16-0846-01A-01W-0424-08	39844781	95604181	38247714	51	10161											
TBX5	6910	broad.mit.edu	37	chr12	114804065	114804065	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctgggaggggccggaaacaCcattctcacactggtattgg	13	11	1	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr12:114804065C>A	uc001tvo.2	-	8	1382	c.887G>T	c.(886-888)GGT>GTT	p.G296V	TBX5_uc001tvp.2_Missense_Mutation_p.G296V|TBX5_uc001tvq.2_Missense_Mutation_p.G246V|TBX5_uc010syv.1_Missense_Mutation_p.G296V	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	296					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GCCGGAAACACCATTCTCACA	0.552													A	114804065	A	A	114804065	3	1	148	1	0	0	0	0	1	0	0	0	15658	507	18	5	744	5	TBX5	12	114804065	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	19199884	114804065	19047830	52	10162											
FAM124A	220108	broad.mit.edu	37	chr13	51825705	51825705	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaggaggccatcgacaacGtcctggcgtggatccacccc	12	15	0	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr13:51825705G>A	uc001vfg.1	+	3	333	c.202G>A	c.(202-204)GTC>ATC	p.V68I	FAM124A_uc001vfe.2_Missense_Mutation_p.V68I|FAM124A_uc001vff.1_Missense_Mutation_p.V104I	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	68										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		CATCGACAACGTCCTGGCGTG	0.682													A	51825705	A	A	51825705	3	1	148	1	0	0	0	0	1	0	0	0	5425	1145	40	1	324	1	FAM124A	13	51825705	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08		51825705	63344173	53	10163											
FOXA1	3169	broad.mit.edu	37	chr14	38061904	38061904	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttcatgttgctgaccgggaCggaggagtaggcctggagtg	18	7	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr14:38061904C>T	uc001wuf.2	-	2	397	c.85G>A	c.(85-87)GTC>ATC	p.V29I	FOXA1_uc010tpz.1_5'UTR	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	29					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		CTGACCGGGACGGAGGAGTAG	0.632													T	38061904	T	T	38061904	3	4	148	1	0	0	0	0	1	0	0	0	5989	536	19	1	1337	1	FOXA1	14	38061904	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08		38061904	69287636	54	10164											
UNC13C	440279	broad.mit.edu	37	chr15	54556392	54556392	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaaaagagttctaaacatGgtgccgaagacaagactcag	10	8	2	4			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr15:54556392G>A	uc002ack.2	+	7	3475	c.3475G>A	c.(3475-3477)GGT>AGT	p.G1159S	UNC13C_uc002acl.2_5'UTR	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1159					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TTCTAAACATGGTGCCGAAGA	0.398													A	54556392	A	A	54556392	3	1	148	1	0	0	0	0	1	0	0	0	16983	1348	47	3	3501	3	UNC13C	15	54556392	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08		54556392	47975000	55	10165											
FAM108C1	58489	broad.mit.edu	37	chr15	81041941	81041941	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggcctcgaggtatgaatgCgcagcggtaattctccattc	11	10	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr15:81041941C>T	uc002bfu.2	+	2	797	c.678C>T	c.(676-678)TGC>TGT	p.C226C	FAM108C1_uc002bft.2_Intron	NM_021214	NP_067037	Q6PCB6	F108C_HUMAN	hypothetical protein LOC58489	226							hydrolase activity				0						GGTATGAATGCGCAGCGGTAA	0.507													T	81041941	T	T	81041941	2	4	148	1	0	0	0	0	0	0	0	1	5393	776	27	1		1	FAM108C1	15	81041941	Silent	SNP	C	TCGA-16-0846-01A-01W-0424-08	26485549	81041941	21489451	56	10166											
SLC28A1	9154	broad.mit.edu	37	chr15	85448820	85448820	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggactgcagtttgtacttggActcctcgtcatcagaacaga	10	10	2	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr15:85448820A>T	uc002blg.2	+	8	856	c.654A>T	c.(652-654)GGA>GGT	p.G218G	SLC28A1_uc010upd.1_Silent_p.G140G|SLC28A1_uc010bnb.2_Silent_p.G218G|SLC28A1_uc010upe.1_Silent_p.G218G|SLC28A1_uc010upf.1_Silent_p.G218G|SLC28A1_uc010upg.1_Silent_p.G218G	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	218	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TTGTACTTGGACTCCTCGTCA	0.567													T	85448820	T	T	85448820	2	4	148	1	0	0	0	0	0	0	0	1	14531	262	10	5		5	SLC28A1	15	85448820	Silent	SNP	A	TCGA-16-0846-01A-01W-0424-08	4406879	85448820	17082572	57	10167											
IL4R	3566	broad.mit.edu	37	chr16	27357926	27357926	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agtcaacatttggagtgaaaAcgacccggcagatgtgagtg	13	7	1	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr16:27357926A>T	uc002don.2	+	6	742	c.500A>T	c.(499-501)AAC>ATC	p.N167I	IL4R_uc002dom.2_Missense_Mutation_p.N167I|IL4R_uc002dop.3_Missense_Mutation_p.N152I|IL4R_uc010bxy.2_Missense_Mutation_p.N167I|IL4R_uc002doo.2_Missense_Mutation_p.T9S	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	167	Extracellular (Potential).|Fibronectin type-III.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						TGGAGTGAAAACGACCCGGCA	0.542													T	27357926	T	T	27357926	3	4	148	1	0	0	0	0	1	0	0	0	7698	43	2	5	514	5	IL4R	16	27357926	Missense_Mutation	SNP	A	TCGA-16-0846-01A-01W-0424-08		27357926	62996827	58	10168											
ZNF319	57567	broad.mit.edu	37	chr16	58030933	58030933	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcacttgtgccgcagcagctCggcagattggtcaaagcctt	12	12	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr16:58030933C>T	uc002emx.1	-	2	1860	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	413	C2H2-type 11; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGCAGCAGCTCGGCAGATTGG	0.647													T	58030933	T	T	58030933	3	4	148	1	0	0	0	0	1	0	0	0	17834	893	31	2	515	2	ZNF319	16	58030933	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	30673007	58030933	32323820	59	10169											
HYDIN	54768	broad.mit.edu	37	chr16	70917863	70917863	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaaagtgtaaagaatgccGgcagggtggactgcagggtc	16	7	0	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr16:70917863G>A	uc002ezr.2	-	59	10064	c.9936C>T	c.(9934-9936)GCC>GCT	p.A3312A		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3313										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AAAGAATGCCGGCAGGGTGGA	0.488													A	70917863	A	A	70917863	2	1	148	1	0	0	0	0	0	0	0	1	7467	1103	39	2		2	HYDIN	16	70917863	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	12886930	70917863	19436890	60	10170											
MYBBP1A	10514	broad.mit.edu	37	chr17	4449142	4449142	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ctcgtgaccaaggacccaccGatggtcttggtgcggctccg	13	14	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr17:4449142G>C	uc002fyb.3	-	14	1982	c.1920C>G	c.(1918-1920)ATC>ATG	p.I640M	MYBBP1A_uc002fxz.3_Missense_Mutation_p.I640M|MYBBP1A_uc010vsa.1_5'Flank	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	640					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						AGGACCCACCGATGGTCTTGG	0.652													C	4449142	C	C	4449142	3	2	148	1	0	0	0	0	1	0	0	0	10008	1072	37	5	2158	5	MYBBP1A	17	4449142	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08		4449142	76746068	61	10171											
TP53	7157	broad.mit.edu	37	chr17	7578395	7578395	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctatctgagcagcgctcatGgtgggggcagcgcctcacaa	14	12	3	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr17:7578395G>A	uc002gim.2	-	5	729	c.535C>T	c.(535-537)CAT>TAT	p.H179Y	TP53_uc002gig.1_Missense_Mutation_p.H179Y|TP53_uc002gih.2_Missense_Mutation_p.H179Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47Y|TP53_uc010cng.1_Missense_Mutation_p.H47Y|TP53_uc002gii.1_Missense_Mutation_p.H47Y|TP53_uc010cnh.1_Missense_Mutation_p.H179Y|TP53_uc010cni.1_Missense_Mutation_p.H179Y|TP53_uc002gij.2_Missense_Mutation_p.H179Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86Y|TP53_uc002gio.2_Missense_Mutation_p.H47Y|TP53_uc010vug.1_Missense_Mutation_p.H140Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCTCATGGTGGGGGCAG	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578395	A	A	7578395	3	1	148	1	0	0	0	0	1	0	0	0	16378	1348	47	3	763	3	TP53	17	7578395	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	3129253	7578395	73616815	62	10172											
MYOCD	93649	broad.mit.edu	37	chr17	12656063	12656063	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctccttcggcctgcacccGtccccagtccacgtgtgcac	8	21	0	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr17:12656063G>A	uc002gnn.2	+	10	1757	c.1458G>A	c.(1456-1458)CCG>CCA	p.P486P	MYOCD_uc002gno.2_Silent_p.P486P|MYOCD_uc002gnp.1_Silent_p.P390P|MYOCD_uc002gnq.2_Silent_p.P205P	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	486	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GCCTGCACCCGTCCCCAGTCC	0.632													A	12656063	A	A	12656063	2	1	148	1	0	0	0	0	0	0	0	1	10087	1132	40	1		1	MYOCD	17	12656063	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	5077668	12656063	68539147	63	10173											
LRRC30	339291	broad.mit.edu	37	chr18	7231554	7231554	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggccgagctgagcttgtgcCgaaagctggaggtcctgagc	16	11	0	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr18:7231554C>T	uc010wzk.1	+	1	418	c.418C>T	c.(418-420)CGA>TGA	p.R140*		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	140										ovary(1)|liver(1)	2						GAGCTTGTGCCGAAAGCTGGA	0.572													T	7231554	T	T	7231554	4	4	148	1	0	0	0	0	0	1	0	0	8985	644	23	2	420	2	LRRC30	18	7231554	Nonsense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08		7231554	70845694	64	10174											
MIB1	57534	broad.mit.edu	37	chr18	19395686	19395686	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaatgctcgaaacaagcgccGacagacaccacttcatattg	8	12	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr18:19395686G>A	uc002ktq.2	+	11	1589	c.1589G>A	c.(1588-1590)CGA>CAA	p.R530Q	MIB1_uc002ktp.2_Missense_Mutation_p.R169Q	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	530	ANK 4.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			AACAAGCGCCGACAGACACCA	0.438													A	19395686	A	A	19395686	3	1	148	1	0	0	0	0	1	0	0	0	9566	1058	37	2	1631	2	MIB1	18	19395686	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	12164132	19395686	58681562	65	10175											
SERPINB11	89778	broad.mit.edu	37	chr18	61377523	61377523	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gataacatcttcttttcttcGctgagtctgctttatgctct	6	10	5	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr18:61377523G>A	uc002ljk.3	+	2	158	c.96G>A	c.(94-96)TCG>TCA	p.S32S	SERPINB11_uc010xes.1_5'UTR|SERPINB11_uc010dqd.2_5'UTR|SERPINB11_uc002ljj.3_5'UTR|SERPINB11_uc010dqe.2_5'UTR|SERPINB11_uc010dqf.2_Silent_p.S32S	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	32					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				TCTTTTCTTCGCTGAGTCTGC	0.433													A	61377523	A	A	61377523	2	1	148	1	0	0	0	0	0	0	0	1	14098	1074	38	1		1	SERPINB11	18	61377523	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	41981837	61377523	16699725	66	10176											
SALL3	27164	broad.mit.edu	37	chr18	76753193	76753193	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagcaccgcaagggcaagcCgcccaatgtgtcggtgttcg	14	12	0	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr18:76753193C>T	uc002lmt.2	+	2	1202	c.1202C>T	c.(1201-1203)CCG>CTG	p.P401L	SALL3_uc010dra.2_Missense_Mutation_p.P8L	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		AAGGGCAAGCCGCCCAATGTG	0.662													T	76753193	T	T	76753193	3	4	148	1	0	0	0	0	1	0	0	0	13812	652	23	2	1208	2	SALL3	18	76753193	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	15375670	76753193	1324055	67	10177											
HCN2	610	broad.mit.edu	37	chr19	605149	605149	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgctctgccactgggacgGctgcctgcagttcctggtgc	14	14	1	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:605149G>A	uc002lpe.2	+	3	1198	c.1145G>A	c.(1144-1146)GGC>GAC	p.G382D		NM_001194	NP_001185	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic	382	Helical; Name=Segment S5; (Potential).				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACTGGGACGGCTGCCTGCAG	0.617													A	605149	A	A	605149	3	1	148	1	0	0	0	0	1	0	0	0	6997	1203	42	3	1155	3	HCN2	19	605149	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08		605149	58523834	68	10178											
REEP6	92840	broad.mit.edu	37	chr19	1496383	1496383	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgttcctaaggcaccacgggGccgtagacagaatcatgaac	11	11	1	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:1496383G>T	uc002ltc.2	+	4	552	c.448G>T	c.(448-450)GCC>TCC	p.A150S		NM_138393	NP_612402	Q96HR9	REEP6_HUMAN	receptor accessory protein 6	150						integral to membrane					0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACCACGGGGCCGTAGACAG	0.657													T	1496383	T	T	1496383	3	4	148	1	0	0	0	0	1	0	0	0	13209	1203	42	5	462	5	REEP6	19	1496383	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	891234	1496383	57632600	69	10179											
ADAT3	113179	broad.mit.edu	37	chr19	1912807	1912807	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgtggcgcgcggccagggccGcggcacctacgacttcagac	15	16	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:1912807G>T	uc002luh.2	+	2	941	c.713G>T	c.(712-714)CGC>CTC	p.R238L	SCAMP4_uc002lui.1_Intron|SCAMP4_uc002luj.2_Intron|SCAMP4_uc002luk.2_Intron|SCAMP4_uc010dss.2_Intron	NM_138422	NP_612431	Q96EY9	ADAT3_HUMAN	tRNA-specific adenosine deaminase 3	238					tRNA processing		hydrolase activity|zinc ion binding			breast(1)|skin(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCAGGGCCGCGGCACCTAC	0.741													T	1912807	T	T	1912807	3	4	148	1	0	0	0	0	1	0	0	0	286	1087	38	5	715	5	ADAT3	19	1912807	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	416424	1912807	57216176	70	10180											
ILF3	3609	broad.mit.edu	37	chr19	10794068	10794068	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtggatggacagaagttccaAggtgctggttccaacaaaaa	12	7	0	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:10794068A>G	uc002mpn.2	+	15	2018	c.1701A>G	c.(1699-1701)CAA>CAG	p.Q567Q	ILF3_uc002mpm.2_Silent_p.Q571Q|ILF3_uc002mpl.2_Silent_p.Q567Q|ILF3_uc002mpk.2_Silent_p.Q567Q|ILF3_uc010xli.1_Silent_p.Q165Q|ILF3_uc002mpo.2_Silent_p.Q571Q|ILF3_uc002mpp.2_Silent_p.Q392Q|ILF3_uc002mpq.2_5'Flank	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	567	DRBM 2.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			AGAAGTTCCAAGGTGCTGGTT	0.572													G	10794068	G	G	10794068	2	3	148	1	0	0	0	0	0	0	0	1	7712	69	3	4		4	ILF3	19	10794068	Silent	SNP	A	TCGA-16-0846-01A-01W-0424-08	8881261	10794068	48334915	71	10181											
OR10H5	284433	broad.mit.edu	37	chr19	15905136	15905136	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccacccagcgctccatcgCcttcctggcctgtgccagtc	9	19	0	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:15905136C>T	uc010xos.1	+	1	278	c.278C>T	c.(277-279)GCC>GTC	p.A93V		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CGCTCCATCGCCTTCCTGGCC	0.607													T	15905136	T	T	15905136	3	4	148	1	0	0	0	0	1	0	0	0	10909	739	26	3	280	3	OR10H5	19	15905136	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	5111068	15905136	43223847	72	10182											
MYO9B	4650	broad.mit.edu	37	chr19	17312748	17312748	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttccagataaatgacctccGttcccagaagacgcccattg	7	14	0	4			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:17312748G>A	uc010eak.2	+	27	4729	c.4577G>A	c.(4576-4578)CGT>CAT	p.R1526H	MYO9B_uc002nfi.2_Missense_Mutation_p.R1526H|MYO9B_uc002nfj.1_Missense_Mutation_p.R1526H|MYO9B_uc002nfl.1_Missense_Mutation_p.R75H	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1526	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						AATGACCTCCGTTCCCAGAAG	0.572													A	17312748	A	A	17312748	3	1	148	1	0	0	0	0	1	0	0	0	10085	1145	40	1	4679	1	MYO9B	19	17312748	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	1407612	17312748	41816235	73	10183											
PIK3R2	5296	broad.mit.edu	37	chr19	18280016	18280016	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gctgcactaccagcacgcctCgctggtgcagcacaacgacg	11	16	0	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:18280016C>T	uc002nia.1	+	16	2611	c.2099C>T	c.(2098-2100)TCG>TTG	p.S700L	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	700	SH2 2.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						CAGCACGCCTCGCTGGTGCAG	0.542													T	18280016	T	T	18280016	3	4	148	1	0	0	0	0	1	0	0	0	11919	893	31	2	2157	2	PIK3R2	19	18280016	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	967268	18280016	40848967	74	10184											
TSHZ3	57616	broad.mit.edu	37	chr19	31769684	31769685	+	Frame_Shift_Ins	INS	-	T	T													atggtggctttgggggttccINSacctgtggaatctggggagc							TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:31769684_31769685insT	uc002nsy.3	-	2	1079_1080	c.1014_1015insA	c.(1012-1017)GGTGGAfs	p.G338fs		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	338_339					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TTGGGGGTTCCACCTGTGGAAT	0.564													T	31769685	T	T	31769684	7	5	148	1	0	1	1	0	0	0	0	0	16622	603	21	0	2234	0	TSHZ3	19	31769684	Frame_Shift_Ins	INS	-	TCGA-16-0846-01A-01W-0424-08	13489668	31769684	27359299	75	10185											
SLC7A10	56301	broad.mit.edu	37	chr19	33706697	33706697	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agccaggcccccgaagatctCtgtgacgtaggcgtagtccc	12	14	1	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:33706697C>T	uc002num.2	-	2	481	c.334G>A	c.(334-336)GAG>AAG	p.E112K	SLC7A10_uc010xrq.1_Intron	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	112			E -> D (in a family with cystinuria).		blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					CCGAAGATCTCTGTGACGTAG	0.657													T	33706697	T	T	33706697	3	4	148	1	0	0	0	0	1	0	0	0	14693	922	32	3	1277	3	SLC7A10	19	33706697	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08	1937013	33706697	25422286	76	10186											
FAM71E1	112703	broad.mit.edu	37	chr19	50979619	50979619	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctggagggggcggctcctgGagatcaggccaaaggggcgg	20	10	1	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:50979619G>A	uc002psh.2	-	1	385	c.27C>T	c.(25-27)CTC>CTT	p.L9L	FAM71E1_uc002psg.2_Silent_p.L9L|FAM71E1_uc002psi.2_RNA|C19orf63_uc002psj.2_5'Flank|C19orf63_uc002psk.2_5'Flank|C19orf63_uc002psl.2_5'Flank	NM_138411	NP_612420	Q6IPT2	F71E1_HUMAN	hypothetical protein LOC112703	9										breast(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		GCGGCTCCTGGAGATCAGGCC	0.682													A	50979619	A	A	50979619	2	1	148	1	0	0	0	0	0	0	0	1	5611	1161	41	3		3	FAM71E1	19	50979619	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	17272922	50979619	8149364	77	10187											
ZNF776	284309	broad.mit.edu	37	chr19	58265771	58265771	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acctcactgaacaccagagaGttcacactggagaaaggcca	9	12	2	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr19:58265771G>T	uc002qpx.2	+	3	1496	c.1273G>T	c.(1273-1275)GTT>TTT	p.V425F	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Missense_Mutation_p.V425F	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	425	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		ACACCAGAGAGTTCACACTGG	0.428													T	58265771	T	T	58265771	3	4	148	1	0	0	0	0	1	0	0	0	18146	1029	36	5	1283	5	ZNF776	19	58265771	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	7286152	58265771	863212	78	10188											
SEL1L2	80343	broad.mit.edu	37	chr20	13830942	13830942	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtttgagcagccatgtcgtaCaatcttctggccaagtgaat	10	9	2	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr20:13830942C>A	uc010gcf.2	-	19	1924	c.1842G>T	c.(1840-1842)TTG>TTT	p.L614F	SEL1L2_uc002woq.3_Missense_Mutation_p.L475F|SEL1L2_uc010zrl.1_Missense_Mutation_p.L501F|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	614	Extracellular (Potential).|Sel1-like 11.					integral to membrane	binding			ovary(2)	2						CCATGTCGTACAATCTTCTGG	0.448													A	13830942	A	A	13830942	3	1	148	1	0	0	0	0	1	0	0	0	14011	477	17	5	232	5	SEL1L2	20	13830942	Missense_Mutation	SNP	C	TCGA-16-0846-01A-01W-0424-08		13830942	49194578	79	10189											
ZBP1	81030	broad.mit.edu	37	chr20	56190589	56190589	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgttgttggctgaactgagGgccaggggtctctggaattg	16	8	1	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr20:56190589G>A	uc002xyo.2	-	3	588	c.307C>T	c.(307-309)CCT>TCT	p.P103S	ZBP1_uc010gjm.2_Missense_Mutation_p.P103S|ZBP1_uc002xyp.2_Missense_Mutation_p.P28S|ZBP1_uc010zzn.1_Missense_Mutation_p.P103S	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	103	DRADA 2.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			CTGAACTGAGGGCCAGGGGTC	0.592													A	56190589	A	A	56190589	3	1	148	1	0	0	0	0	1	0	0	0	17518	1232	43	3	1083	3	ZBP1	20	56190589	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	42359647	56190589	6834931	80	10190											
C1QTNF6	114904	broad.mit.edu	37	chr22	37578306	37578306	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgctgtagatggcgttctcGcgctggcgcttgaagagccg	15	10	1	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr22:37578306G>A	uc003aqw.1	-	2	1207	c.702C>T	c.(700-702)CGC>CGT	p.R234R	C1QTNF6_uc003aqx.1_Silent_p.R253R|C1QTNF6_uc003aqy.1_Silent_p.R253R|C1QTNF6_uc003aqz.1_RNA	NM_182486	NP_872292	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6	234	C1q.					collagen					0						TGGCGTTCTCGCGCTGGCGCT	0.652													A	37578306	A	A	37578306	2	1	148	1	0	0	0	0	0	0	0	1	1967	1074	38	1		1	C1QTNF6	22	37578306	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08		37578306	13726260	81	10191											
SH3BP1	23616	broad.mit.edu	37	chr22	38046222	38046222	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtgggcgtcgtcgaggcGctgatccagagcgcagacac	17	11	0	3			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr22:38046222G>A	uc003ati.2	+	15	1491	c.1380G>A	c.(1378-1380)GCG>GCA	p.A460A	SH3BP1_uc003atg.1_RNA|SH3BP1_uc011anl.1_Missense_Mutation_p.R493H|SH3BP1_uc003ath.1_Silent_p.A460A|SH3BP1_uc003atj.1_Silent_p.A396A|SH3BP1_uc003atk.1_Silent_p.A374A|uc003atl.1_Intron	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	460	Rho-GAP.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TCGTCGAGGCGCTGATCCAGA	0.577													A	38046222	A	A	38046222	2	1	148	1	0	0	0	0	0	0	0	1	14244	1074	38	1		1	SH3BP1	22	38046222	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	467916	38046222	13258344	82	10192											
SMC1B	27127	broad.mit.edu	37	chr22	45754668	45754668	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgggtactttctgcttcaGttcccatctgaaaaatatgt	7	10	3	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chr22:45754668G>A	uc003bgc.2	-	19	2922	c.2870C>T	c.(2869-2871)ACT>ATT	p.T957I	SMC1B_uc003bgd.2_Missense_Mutation_p.T957I	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	957					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TTCTGCTTCAGTTCCCATCTG	0.214													A	45754668	A	A	45754668	3	1	148	1	0	0	0	0	1	0	0	0	14782	1029	36	3	865	3	SMC1B	22	45754668	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08	7708446	45754668	5549898	83	10193											
DMD	1756	broad.mit.edu	37	chrX	32429932	32429932	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atataagctgccaactgcttGtcaatgaatgtgagggactc	10	8	1	2			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chrX:32429932G>C	uc004dda.1	-	30	4414	c.4170C>G	c.(4168-4170)GAC>GAG	p.D1390E	DMD_uc004dcw.2_Missense_Mutation_p.D46E|DMD_uc004dcx.2_Missense_Mutation_p.D49E|DMD_uc004dcz.2_Missense_Mutation_p.D1267E|DMD_uc004dcy.1_Missense_Mutation_p.D1386E|DMD_uc004ddb.1_Missense_Mutation_p.D1382E|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1390					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCAACTGCTTGTCAATGAATG	0.473													C	32429932	C	C	32429932	3	2	148	1	0	0	0	0	1	0	0	0	4580	1368	48	5	7235	5	DMD	23	32429932	Missense_Mutation	SNP	G	TCGA-16-0846-01A-01W-0424-08		32429932	122840628	84	10194											
USP11	8237	broad.mit.edu	37	chrX	47104414	47104414	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccacctctccctcacccccaGcccagccgtacattgctatc	4	22	2	0			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chrX:47104414G>C	uc004dhp.2	+	16	2216	c.2216_splice	c.e16-1	p.A739_splice	USP11_uc004dhq.2_Splice_Site_p.A465_splice	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11						protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CTCACCCCCAGCCCAGCCGTA	0.567													C	47104414	C	C	47104414	5	2	148	1	0	0	0	0	0	0	1	0	17039	985	34	5	2277	5	USP11	23	47104414	Splice_Site	SNP	G	TCGA-16-0846-01A-01W-0424-08	14674482	47104414	108166146	85	10195											
PCDH11X	27328	broad.mit.edu	37	chrX	91133526	91133526	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	taggacagcctgattctctcTtcagtgttgtaattgtcaat	8	8	4	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chrX:91133526T>A	uc004efk.1	+	2	3132	c.2287T>A	c.(2287-2289)TTC>ATC	p.F763I	PCDH11X_uc004efl.1_Missense_Mutation_p.F763I|PCDH11X_uc004efo.1_Missense_Mutation_p.F763I|PCDH11X_uc010nmv.1_Missense_Mutation_p.F763I|PCDH11X_uc004efm.1_Missense_Mutation_p.F763I|PCDH11X_uc004efn.1_Missense_Mutation_p.F763I|PCDH11X_uc004efh.1_Missense_Mutation_p.F763I|PCDH11X_uc004efj.1_Missense_Mutation_p.F763I	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	763	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TGATTCTCTCTTCAGTGTTGT	0.433													A	91133526	A	A	91133526	3	1	148	1	0	0	0	0	1	0	0	0	11508	1609	56	5	2293	5	PCDH11X	23	91133526	Missense_Mutation	SNP	T	TCGA-16-0846-01A-01W-0424-08	44029112	91133526	64137034	86	10196											
GABRE	2564	broad.mit.edu	37	chrX	151124002	151124002	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggaaattcttacgagaaaaGgtgcccaacgtggtcatggt	13	7	2	1			TCGA-16-0846-01A-01W-0424-08	TCGA-16-0846-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	cf3eb226-36c2-4498-a5c1-3f161de6fa3f	2f7cbc27-2715-4414-b1b0-601ba7627d40	g.chrX:151124002G>T	uc004ffi.2	-	8	1029	c.975C>A	c.(973-975)ACC>ACA	p.T325T	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	325					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TACGAGAAAAGGTGCCCAACG	0.493													T	151124002	T	T	151124002	2	4	148	1	0	0	0	0	0	0	0	1	6170	987	35	5		5	GABRE	23	151124002	Silent	SNP	G	TCGA-16-0846-01A-01W-0424-08	59990476	151124002	4146558	87	10197											
DNAJC6	9829	broad.mit.edu	37	chr1	65845142	65845142	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctgcacaacctttttgctGtgtgtcggaatatgtataac	9	8	1	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr1:65845142G>A	uc001dcd.1	+	5	594	c.430G>A	c.(430-432)GTG>ATG	p.V144M	DNAJC6_uc001dcc.1_Missense_Mutation_p.V175M|DNAJC6_uc010opc.1_Missense_Mutation_p.V131M|DNAJC6_uc001dce.1_Missense_Mutation_p.V201M	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	144	Phosphatase tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						CCTTTTTGCTGTGTGTCGGAA	0.458													A	65845142	A	A	65845142	3	1	149	1	0	0	0	0	1	0	0	0	4653	1377	48	3	448	3	DNAJC6	1	65845142	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08		65845142	183405479	1	10198											
VAV3	10451	broad.mit.edu	37	chr1	108417540	108417540	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tacctttccaaagtcacgaaCatcaaacaagtcaaatgcct	4	12	3	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr1:108417540C>A	uc001dvk.1	-	2	358	c.304G>T	c.(304-306)GTT>TTT	p.V102F	VAV3_uc010ouw.1_Missense_Mutation_p.V102F|VAV3_uc001dvl.1_5'UTR|VAV3_uc010oux.1_Missense_Mutation_p.V102F	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	102	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		AAGTCACGAACATCAAACAAG	0.358													A	108417540	A	A	108417540	3	1	149	1	0	0	0	0	1	0	0	0	17130	478	17	5	2368	5	VAV3	1	108417540	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	42572398	108417540	140833081	2	10199											
FLG	2312	broad.mit.edu	37	chr1	152284952	152284952	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tgtccatccatgggaggactCagactgtttatgagtgctca	11	9	2	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr1:152284952C>A	uc001ezu.1	-	3	2446	c.2410G>T	c.(2410-2412)GAG>TAG	p.E804*	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	804	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGGAGGACTCAGACTGTTTA	0.572									Ichthyosis				A	152284952	A	A	152284952	4	1	149	1	0	0	0	0	0	1	0	0	5922	835	29	5	9779	5	FLG	1	152284952	Nonsense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	43867412	152284952	96965669	3	10200											
CD1E	913	broad.mit.edu	37	chr1	158323687	158323687	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtacagcaagggaagtcagaCgagagtgcaagagggtgtgg	18	5	1	3			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr1:158323687C>T	uc001fse.2	+	1	148	c.-91C>T	c.(-93--89)GACGA>GATGA		CD1E_uc010pid.1_Intron|CD1E_uc010pie.1_Translation_Start_Site|CD1E_uc010pif.1_Translation_Start_Site|CD1E_uc001fsd.2_Translation_Start_Site|CD1E_uc001fsk.2_Translation_Start_Site|CD1E_uc001fsj.2_Translation_Start_Site|CD1E_uc001fsc.2_Translation_Start_Site|CD1E_uc010pig.1_RNA|CD1E_uc001fsa.2_Translation_Start_Site|CD1E_uc001fsf.2_Translation_Start_Site|CD1E_uc001fry.2_Translation_Start_Site|CD1E_uc001fsg.2_Translation_Start_Site|CD1E_uc001fsh.2_Translation_Start_Site|CD1E_uc001fsi.2_Translation_Start_Site|CD1E_uc009wsv.2_Translation_Start_Site|CD1E_uc001frz.2_Translation_Start_Site|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor						antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					GGAAGTCAGACGAGAGTGCAA	0.542													T	158323687	T	T	158323687	1	4	149	1	0	0	0	0	0	0	0	0	2978	551	19	1		1	CD1E	1	158323687	Translation_Start_Site	SNP	C	TCGA-16-0861-01A-01W-0424-08	6038735	158323687	90926934	4	10201											
EHD3	30845	broad.mit.edu	37	chr2	31467312	31467312	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctttggcaacgccttcttgAacaggtgagtgtggagggaa	14	8	1	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr2:31467312A>T	uc002rnu.2	+	2	1008	c.400A>T	c.(400-402)AAC>TAC	p.N134Y	EHD3_uc010ymt.1_Missense_Mutation_p.N134Y	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	134					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					CGCCTTCTTGAACAGGTGAGT	0.537													T	31467312	T	T	31467312	3	4	149	1	0	0	0	0	1	0	0	0	4979	246	9	5	406	5	EHD3	2	31467312	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08		31467312	211732061	5	10202											
BIRC6	57448	broad.mit.edu	37	chr2	32774411	32774411	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttacataaatcccgtcagtaGtgcggtaaatggagaagctc	10	8	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr2:32774411G>A	uc010ezu.2	+	65	13141	c.13007G>A	c.(13006-13008)AGT>AAT	p.S4336N		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4336					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CCCGTCAGTAGTGCGGTAAAT	0.398													A	32774411	A	A	32774411	3	1	149	1	0	0	0	0	1	0	0	0	1438	1029	36	3	13265	3	BIRC6	2	32774411	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	1307099	32774411	210424962	6	10203											
TUBA3D	113457	broad.mit.edu	37	chr2	132237806	132237806	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccccccaggtctccacagcCgtggtggagccctacaactc	10	18	1	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr2:132237806C>T	uc002tsu.3	+	4	647	c.540C>T	c.(538-540)GCC>GCT	p.A180A		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	180					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		TCTCCACAGCCGTGGTGGAGC	0.547													T	132237806	T	T	132237806	2	4	149	1	0	0	0	0	0	0	0	1	16744	639	23	2		2	TUBA3D	2	132237806	Silent	SNP	C	TCGA-16-0861-01A-01W-0424-08	99463395	132237806	110961567	7	10204											
LY75	4065	broad.mit.edu	37	chr2	160729003	160729003	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaagaaattcctttatttcAtccacatggctgaagctaga	7	8	1	4			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr2:160729003A>G	uc002ubc.3	-	13	2145	c.2076T>C	c.(2074-2076)GAT>GAC	p.D692D	LY75_uc002ubb.3_Silent_p.D692D|LY75_uc010fos.2_Silent_p.D692D|LY75_uc010fot.1_Silent_p.D692D	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	692	Extracellular (Potential).|C-type lectin 4.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		CCTTTATTTCATCCACATGGC	0.378													G	160729003	G	G	160729003	2	3	149	1	0	0	0	0	0	0	0	1	9099	214	8	4		4	LY75	2	160729003	Silent	SNP	A	TCGA-16-0861-01A-01W-0424-08	28491197	160729003	82470370	8	10205											
PDE11A	50940	broad.mit.edu	37	chr2	178969184	178969184	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taaaggtcttcttgcctgctTcagcatctcccatgttgctc	7	13	4	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr2:178969184T>C	uc002ulr.2	-	2	106	c.7A>G	c.(7-9)AAG>GAG	p.K3E	PDE11A_uc002ult.1_Missense_Mutation_p.K3E	NM_001077197	NP_001070665	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 3	Error:Variant_position_missing_in_Q9HCR9_after_alignment					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CTTGCCTGCTTCAGCATCTCC	0.408									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				C	178969184	C	C	178969184	3	2	149	1	0	0	0	0	1	0	0	0	11631	1792	62	4	3040	4	PDE11A	2	178969184	Missense_Mutation	SNP	T	TCGA-16-0861-01A-01W-0424-08	18240181	178969184	64230189	9	10206											
TTN	7273	broad.mit.edu	37	chr2	179442852	179442852	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaagtctctcatccttatcGgagtcttgttagctctcttc	6	11	4	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr2:179442852G>A	uc010zfg.1	-	271	60910	c.60686C>T	c.(60685-60687)CCG>CTG	p.P20229L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P13924L|TTN_uc010zfi.1_Missense_Mutation_p.P13857L|TTN_uc010zfj.1_Missense_Mutation_p.P13732L|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21156							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCCTTATCGGAGTCTTGTT	0.418													A	179442852	A	A	179442852	3	1	149	1	0	0	0	0	1	0	0	0	16732	1116	39	2	39753	2	TTN	2	179442852	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	473668	179442852	63756521	10	10207											
PTPRN	5798	broad.mit.edu	37	chr2	220159756	220159756	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccctctgccggccagctgagGaagtggaactgcgtgagcgt	15	12	1	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr2:220159756G>A	uc002vkz.2	-	19	2705	c.2616C>T	c.(2614-2616)TTC>TTT	p.F872F	PTPRN_uc010zlc.1_Silent_p.F782F|PTPRN_uc002vla.2_Silent_p.F843F|uc010zld.1_5'Flank|MIR153-1_hsa-mir-153-1|MI0000463_5'Flank	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	872	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GCCAGCTGAGGAAGTGGAACT	0.687													A	220159756	A	A	220159756	2	1	149	1	0	0	0	0	0	0	0	1	12807	1165	41	3		3	PTPRN	2	220159756	Silent	SNP	G	TCGA-16-0861-01A-01W-0424-08	40716904	220159756	23039617	11	10208											
DLEC1	9940	broad.mit.edu	37	chr3	38139020	38139020	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cccagtgaggtcggggatttTgagttgaactttactggggg	16	6	0	3			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr3:38139020T>C	uc003cho.1	+	17	2478	c.2457T>C	c.(2455-2457)TTT>TTC	p.F819F	DLEC1_uc003chp.1_Silent_p.F819F|DLEC1_uc010hgv.1_Silent_p.F819F|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	819					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		TCGGGGATTTTGAGTTGAACT	0.562													C	38139020	C	C	38139020	2	2	149	1	0	0	0	0	0	0	0	1	4552	1809	63	4		4	DLEC1	3	38139020	Silent	SNP	T	TCGA-16-0861-01A-01W-0424-08		38139020	159883410	12	10209											
ATP6V1A	523	broad.mit.edu	37	chr3	113503555	113503555	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atctctaggttggtagtcatAtcactggcggagacatttat	10	7	3	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr3:113503555A>G	uc003eao.2	+	5	505	c.439A>G	c.(439-441)ATC>GTC	p.I147V	ATP6V1A_uc011bik.1_Missense_Mutation_p.I114V	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	147					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						TGGTAGTCATATCACTGGCGG	0.373													G	113503555	G	G	113503555	3	3	149	1	0	0	0	0	1	0	0	0	1177	449	16	4	453	4	ATP6V1A	3	113503555	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08	75364535	113503555	84518875	13	10210											
FRYL	285527	broad.mit.edu	37	chr4	48575256	48575256	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gggatgtaattcctctattaGttccctggaagaaaaatggt	10	6	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr4:48575256G>C	uc003gyh.1	-	26	3456	c.2851C>G	c.(2851-2853)CTA>GTA	p.L951V	FRYL_uc003gyk.2_Missense_Mutation_p.L951V	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	951					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TCCTCTATTAGTTCCCTGGAA	0.348													C	48575256	C	C	48575256	3	2	149	1	0	0	0	0	1	0	0	0	6064	1020	36	5	6346	5	FRYL	4	48575256	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08		48575256	142579020	14	10211											
PITX2	5308	broad.mit.edu	37	chr4	111539315	111539315	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccactgcatactggcaagcaCtcaggttggaggccgggttc	13	12	1	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr4:111539315C>T	uc003iad.2	-	5	1502	c.920G>A	c.(919-921)AGT>AAT	p.S307N	PITX2_uc003iac.2_Missense_Mutation_p.S314N|PITX2_uc003iae.2_Missense_Mutation_p.S261N|PITX2_uc010iml.2_Missense_Mutation_p.S178N|PITX2_uc003iaf.2_Missense_Mutation_p.S307N	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	307					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CTGGCAAGCACTCAGGTTGGA	0.632													T	111539315	T	T	111539315	3	4	149	1	0	0	0	0	1	0	0	0	11955	565	20	3	37	3	PITX2	4	111539315	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	62964059	111539315	79614961	15	10212											
FGA	2243	broad.mit.edu	37	chr4	155508007	155508007	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcatagtccttcagatctaCttcacgagctaaagccctac	5	13	4	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr4:155508007C>T	uc003iod.1	-	5	632	c.574G>A	c.(574-576)GTA>ATA	p.V192I	FGA_uc003ioe.1_Missense_Mutation_p.V192I|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	192	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTCAGATCTACTTCACGAGCT	0.418													T	155508007	T	T	155508007	3	4	149	1	0	0	0	0	1	0	0	0	5830	565	20	3	2078	3	FGA	4	155508007	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	43968692	155508007	35646269	16	10213											
DNAH5	1767	broad.mit.edu	37	chr5	13829731	13829731	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacccttatgataatctgaCggtcaggcaccatcatggcc	8	13	4	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr5:13829731C>T	uc003jfd.2	-	38	6374	c.6332G>A	c.(6331-6333)CGT>CAT	p.R2111H		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2111	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GATAATCTGACGGTCAGGCAC	0.463									Kartagener_syndrome				T	13829731	T	T	13829731	3	4	149	1	0	0	0	0	1	0	0	0	4604	536	19	1	7710	1	DNAH5	5	13829731	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08		13829731	167085529	17	10214											
CMYA5	202333	broad.mit.edu	37	chr5	79030268	79030268	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttctccaaaggatgaaaacTggatgttgggaaagccagaa	11	6	1	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr5:79030268T>G	uc003kgc.2	+	2	5752	c.5680T>G	c.(5680-5682)TGG>GGG	p.W1894G		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1894						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GGATGAAAACTGGATGTTGGG	0.423													G	79030268	G	G	79030268	3	3	149	1	0	0	0	0	1	0	0	0	3590	1580	55	5	5686	5	CMYA5	5	79030268	Missense_Mutation	SNP	T	TCGA-16-0861-01A-01W-0424-08	65200537	79030268	101884992	18	10215											
ZNF608	57507	broad.mit.edu	37	chr5	123983427	123983427	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtgaaagtgtaaaccttatCggcctcagctttgatactgg	10	8	1	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr5:123983427C>T	uc003ktq.1	-	4	2773	c.2650G>A	c.(2650-2652)GAT>AAT	p.D884N	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.D884N|ZNF608_uc003ktt.1_Missense_Mutation_p.D884N	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	884						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TAAACCTTATCGGCCTCAGCT	0.532													T	123983427	T	T	123983427	3	4	149	1	0	0	0	0	1	0	0	0	18031	884	31	2	1912	2	ZNF608	5	123983427	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	44953159	123983427	56931833	19	10216											
PCDHB15	56121	broad.mit.edu	37	chr5	140625602	140625602	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctcccttgggactgtgttTcctctgaaaaaagctcggga	11	10	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr5:140625602T>G	uc003lje.2	+	1	456	c.456T>G	c.(454-456)TTT>TTG	p.F152L		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	152	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACTGTGTTTCCTCTGAAAA	0.438													G	140625602	G	G	140625602	3	3	149	1	0	0	0	0	1	0	0	0	11540	1780	62	5	458	5	PCDHB15	5	140625602	Missense_Mutation	SNP	T	TCGA-16-0861-01A-01W-0424-08	16642175	140625602	40289658	20	10217											
ARHGEF37	389337	broad.mit.edu	37	chr5	148997790	148997790	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctccgggagcggctggcccGcatcaacacacacaccctct	9	19	2	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr5:148997790G>A	uc003lra.1	+	6	774	c.710G>A	c.(709-711)CGC>CAC	p.R237H		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	237					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						CGGCTGGCCCGCATCAACACA	0.632													A	148997790	A	A	148997790	3	1	149	1	0	0	0	0	1	0	0	0	906	1087	38	1	728	1	ARHGEF37	5	148997790	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	8372188	148997790	31917470	21	10218											
CLINT1	9685	broad.mit.edu	37	chr5	157232966	157232966	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgctgctccaagatcaatggTtttggaaggatttgctgtgc	12	7	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr5:157232966T>C	uc003lxj.1	-	7	1040	c.850A>G	c.(850-852)ACC>GCC	p.T284A	CLINT1_uc003lxi.1_Missense_Mutation_p.T266A|CLINT1_uc011ddv.1_Missense_Mutation_p.T284A	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	284					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGATCAATGGTTTTGGAAGGA	0.473													C	157232966	C	C	157232966	3	2	149	1	0	0	0	0	1	0	0	0	3531	1725	60	4	1051	4	CLINT1	5	157232966	Missense_Mutation	SNP	T	TCGA-16-0861-01A-01W-0424-08	8235176	157232966	23682294	22	10219											
N4BP3	23138	broad.mit.edu	37	chr5	177548865	177548865	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcaggaggagaaggagcgcGtgctgcgctaccagcgggag	20	9	0	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr5:177548865G>A	uc003mik.1	+	5	1745	c.1498G>A	c.(1498-1500)GTG>ATG	p.V500M	N4BP3_uc003mil.1_Missense_Mutation_p.V169M	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	500	Potential.					cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAAGGAGCGCGTGCTGCGCTA	0.687													A	177548865	A	A	177548865	3	1	149	1	0	0	0	0	1	0	0	0	10113	1145	40	1	1512	1	N4BP3	5	177548865	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	20315899	177548865	3366395	23	10220											
RASGEF1C	255426	broad.mit.edu	37	chr5	179555514	179555514	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttggtcctgtaggagatggGcttgtcggcacccaccagac	13	12	0	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr5:179555514G>T	uc003mlq.2	-	4	832	c.535C>A	c.(535-537)CCC>ACC	p.P179T	RASGEF1C_uc003mlr.2_Missense_Mutation_p.P179T|RASGEF1C_uc003mlp.3_Missense_Mutation_p.P28T	NM_175062	NP_778232	Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	179					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAGGAGATGGGCTTGTCGGCA	0.637													T	179555514	T	T	179555514	3	4	149	1	0	0	0	0	1	0	0	0	13071	1203	42	5	905	5	RASGEF1C	5	179555514	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	2006649	179555514	1359746	24	10221											
DST	667	broad.mit.edu	37	chr6	56342227	56342227	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagatagccaaaacggtgtcGcccatagtggtggctttatt	11	9	0	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr6:56342227G>A	uc003pdf.2	-	85	15262	c.15234C>T	c.(15232-15234)GGC>GGT	p.G5078G	DST_uc003pcz.3_Silent_p.G4900G|DST_uc011dxj.1_Silent_p.G4929G|DST_uc011dxk.1_Silent_p.G4940G|DST_uc003pcy.3_Silent_p.G4574G	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6986	Spectrin 20.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AAACGGTGTCGCCCATAGTGG	0.458													A	56342227	A	A	56342227	2	1	149	1	0	0	0	0	0	0	0	1	4783	1074	38	1		1	DST	6	56342227	Silent	SNP	G	TCGA-16-0861-01A-01W-0424-08		56342227	114772840	25	10222											
ME1	4199	broad.mit.edu	37	chr6	84056002	84056002	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agggatgcccattccattacAgccaaggtctcccaagccaa	8	14	1	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr6:84056002A>T	uc003pjy.2	-	5	596	c.490T>A	c.(490-492)TGT>AGT	p.C164S	ME1_uc011dzb.1_Missense_Mutation_p.C89S|ME1_uc011dzc.1_5'UTR	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	164					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	ATTCCATTACAGCCAAGGTCT	0.448													T	84056002	T	T	84056002	3	4	149	1	0	0	0	0	1	0	0	0	9417	188	7	5	1268	5	ME1	6	84056002	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08	27713775	84056002	87059065	26	10223											
SAMD9	54809	broad.mit.edu	37	chr7	92732691	92732691	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccttggtgaaaatattctgcCctttcaggatattccggacc	8	11	2	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr7:92732691C>A	uc003umf.2	-	3	2976	c.2720G>T	c.(2719-2721)GGG>GTG	p.G907V	SAMD9_uc003umg.2_Missense_Mutation_p.G907V	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	907						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AATATTCTGCCCTTTCAGGAT	0.333													A	92732691	A	A	92732691	3	1	149	1	0	0	0	0	1	0	0	0	13826	623	22	5	2053	5	SAMD9	7	92732691	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08		92732691	66405972	27	10224											
AZGP1	563	broad.mit.edu	37	chr7	99569575	99569575	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caagggcctgaaacgcggggAcgtcttcaacatgcttggac	13	11	2	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr7:99569575A>T	uc003ush.2	-	2	175	c.131T>A	c.(130-132)GTC>GAC	p.V44D		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	44					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AAACGCGGGGACGTCTTCAAC	0.502													T	99569575	T	T	99569575	3	4	149	1	0	0	0	0	1	0	0	0	1239	275	10	5	777	5	AZGP1	7	99569575	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08	6836884	99569575	59569088	28	10225											
IQUB	154865	broad.mit.edu	37	chr7	123152166	123152166	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tataacctcttccatgagttGttcattgtctggttccaggc	8	10	3	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr7:123152166G>T	uc003vkn.2	-	2	806	c.229C>A	c.(229-231)CAA>AAA	p.Q77K	IQUB_uc003vko.2_Missense_Mutation_p.Q77K|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Missense_Mutation_p.Q77K|IQUB_uc003vkq.2_Missense_Mutation_p.Q77K	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	77										ovary(3)|large_intestine(1)	4						TCCATGAGTTGTTCATTGTCT	0.413													T	123152166	T	T	123152166	3	4	149	1	0	0	0	0	1	0	0	0	7820	1386	48	5	2194	5	IQUB	7	123152166	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	23582591	123152166	35986497	29	10226											
FAM71F1	84691	broad.mit.edu	37	chr7	128370003	128370003	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccttgcacctgtgacctaCgttggagggcttcattcacg	10	13	2	1	rs140953386	byFrequency	TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr7:128370003C>T	uc003vno.1	+	6	954	c.901C>T	c.(901-903)CGT>TGT	p.R301C	FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.R200C|FAM71F1_uc003vnp.1_Missense_Mutation_p.R299C	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	301										skin(1)	1						CTGTGACCTACGTTGGAGGGC	0.547													T	128370003	T	T	128370003	3	4	149	1	0	0	0	0	1	0	0	0	5612	536	19	1	923	1	FAM71F1	7	128370003	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	5217837	128370003	30768660	30	10227											
HIPK2	28996	broad.mit.edu	37	chr7	139416741	139416741	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttggaactcggctctattttCagtttcttcacactacagaa	6	10	4	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr7:139416741C>T	uc003vvf.3	-	2	267	c.93G>A	c.(91-93)CTG>CTA	p.L31L	HIPK2_uc003vvd.3_Silent_p.L31L	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	31					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					GCTCTATTTTCAGTTTCTTCA	0.493													T	139416741	T	T	139416741	2	4	149	1	0	0	0	0	0	0	0	1	7117	813	29	3		3	HIPK2	7	139416741	Silent	SNP	C	TCGA-16-0861-01A-01W-0424-08	11046738	139416741	19721922	31	10228											
CNTNAP2	26047	broad.mit.edu	37	chr7	146829418	146829418	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttacctggaggtgcccggaCggcttaaccaggacctgttc	13	12	0	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr7:146829418C>T	uc003weu.1	+	8	1681	c.1165C>T	c.(1165-1167)CGG>TGG	p.R389W		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	389	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.R389Q(1)		ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGTGCCCGGACGGCTTAACCA	0.468										HNSCC(39;0.1)			T	146829418	T	T	146829418	3	4	149	1	0	0	0	0	1	0	0	0	3647	527	19	1	1195	1	CNTNAP2	7	146829418	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	7412677	146829418	12309245	32	10229											
IARS	3376	broad.mit.edu	37	chr9	95007245	95007246	+	Missense_Mutation	DNP	GC	AA	AA													ggaaacagaaaaatacctgaGcatctgagtgtgcttcaaat							TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr9:95007245_95007246GC>AA	uc004art.1	-	27	3156_3157	c.2899_2900GC>TT	c.(2899-2901)GCT>TTT	p.A967F	IARS_uc004ars.1_Missense_Mutation_p.A812F|IARS_uc004aru.3_Missense_Mutation_p.A967F|IARS_uc010mqr.2_Missense_Mutation_p.A857F|IARS_uc010mqt.2_Missense_Mutation_p.A190F	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	967					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	AAATACCTGAGCATCTGAGTGT	0.446													AA	95007246	AA	AA	95007245	3	1	149	1	0	0	0	0	1	0	0	0	7473	971	34	3	920	3	IARS	9	95007245	Missense_Mutation	DNP	GC	TCGA-16-0861-01A-01W-0424-08		95007245	46206186	33	10230											
LPAR1	1902	broad.mit.edu	37	chr9	113703772	113703772	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccggggtccagaactatgcCgagacattctcatagtcctc	10	13	1	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr9:113703772C>T	uc004bfa.2	-	4	977	c.722G>A	c.(721-723)CGG>CAG	p.R241Q	LPAR1_uc011lwm.1_Missense_Mutation_p.R242Q|LPAR1_uc004bfb.2_Missense_Mutation_p.R241Q|LPAR1_uc004bfc.2_Missense_Mutation_p.R241Q|LPAR1_uc011lwn.1_Missense_Mutation_p.R223Q|LPAR1_uc011lwo.1_Missense_Mutation_p.R242Q|LPAR1_uc010mub.2_Missense_Mutation_p.R241Q	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	241	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						AGAACTATGCCGAGACATTCT	0.468													T	113703772	T	T	113703772	3	4	149	1	0	0	0	0	1	0	0	0	8904	652	23	2	380	2	LPAR1	9	113703772	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	18696527	113703772	27509659	34	10231											
SUSD1	64420	broad.mit.edu	37	chr9	114860875	114860875	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctacaggcacttgttccctcGttgtgaagttaaacgatgtt	9	9	0	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr9:114860875G>T	uc004bfu.2	-	10	1390	c.1349C>A	c.(1348-1350)ACG>AAG	p.T450K	SUSD1_uc010mui.2_Missense_Mutation_p.T450K|SUSD1_uc010muj.2_Missense_Mutation_p.T450K	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	450	Extracellular (Potential).					integral to membrane	calcium ion binding				0						TTGTTCCCTCGTTGTGAAGTT	0.443													T	114860875	T	T	114860875	3	4	149	1	0	0	0	0	1	0	0	0	15404	1145	40	5	926	5	SUSD1	9	114860875	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	1157103	114860875	26352556	35	10232											
PTEN	5728	broad.mit.edu	37	chr10	89685315	89685318	+	Splice_Site	DEL	GTAA	-	-													cattacaagatatacaatctGtaagtatgttttcttatttg							TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr10:89685315_89685318delGTAA	uc001kfb.2	+	4	1240	c.209_splice	c.e4+1	p.L70_splice		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(15)|p.R55fs*1(4)|p.L70fs*7(2)|p.Y27fs*1(2)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TATACAATCTGTAAGTATGTTTTC	0.275		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89685318	-	-	89685315	8	5	149	1	0	1	0	1	0	0	1	0	12738	1391	48	0	220	0	PTEN	10	89685315	Splice_Site	DEL	GTAA	TCGA-16-0861-01A-01W-0424-08		89685315	45849432	36	10233											
BTRC	8945	broad.mit.edu	37	chr10	103281492	103281492	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggaactgtgtgtcaaatacTttgagcagtggtcagagtca	12	6	3	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr10:103281492T>G	uc001kta.2	+	5	534	c.421T>G	c.(421-423)TTT>GTT	p.F141V	BTRC_uc001ktb.2_Missense_Mutation_p.F105V|BTRC_uc001ktc.2_Missense_Mutation_p.F115V	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	141	Homodimerization domain D.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		TGTCAAATACTTTGAGCAGTG	0.413													G	103281492	G	G	103281492	3	3	149	1	0	0	0	0	1	0	0	0	1569	1609	56	5	439	5	BTRC	10	103281492	Missense_Mutation	SNP	T	TCGA-16-0861-01A-01W-0424-08	13596177	103281492	32253255	37	10234											
PITX3	5309	broad.mit.edu	37	chr10	103990780	103990780	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagccccccgagcggcgccgCgaagctgcctttgcatagct	12	17	0	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr10:103990780C>A	uc001kuu.1	-	4	554	c.400G>T	c.(400-402)GCG>TCG	p.A134S		NM_005029	NP_005020	O75364	PITX3_HUMAN	paired-like homeodomain 3	134					dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGCGGCGCCGCGAAGCTGCCT	0.711													A	103990780	A	A	103990780	3	1	149	1	0	0	0	0	1	0	0	0	11956	768	27	5	512	5	PITX3	10	103990780	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	709288	103990780	31543967	38	10235											
C11orf30	56946	broad.mit.edu	37	chr11	76164415	76164415	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcagtaaacgatgaacggttAacaacaattgcacataagta	8	7	0	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr11:76164415A>C	uc001oxl.2	+	4	371	c.228A>C	c.(226-228)TTA>TTC	p.L76F	C11orf30_uc001oxj.2_Missense_Mutation_p.L76F|C11orf30_uc001oxk.2_Missense_Mutation_p.L76F|C11orf30_uc009yuj.1_Missense_Mutation_p.L76F|C11orf30_uc010rsa.1_Missense_Mutation_p.L76F|C11orf30_uc001oxm.2_Missense_Mutation_p.L76F|C11orf30_uc010rsb.1_Missense_Mutation_p.L76F|C11orf30_uc010rsc.1_Missense_Mutation_p.L76F|C11orf30_uc001oxn.2_Missense_Mutation_p.L76F|C11orf30_uc010rsd.1_Missense_Mutation_p.L76F	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	76	Interaction with BRCA2.|ENT.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						ATGAACGGTTAACAACAATTG	0.403													C	76164415	C	C	76164415	3	2	149	1	0	0	0	0	1	0	0	0	1636	359	13	5	238	5	C11orf30	11	76164415	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08		76164415	58842101	39	10236											
ELMOD1	55531	broad.mit.edu	37	chr11	107518220	107518220	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaattcttgaagcccaatacTccactggaatctcggatttc	6	11	2	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr11:107518220T>A	uc010rvs.1	+	7	851	c.447T>A	c.(445-447)ACT>ACA	p.T149T	ELMOD1_uc001pjm.2_Silent_p.T149T|ELMOD1_uc010rvt.1_Silent_p.T143T	NM_018712	NP_061182	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1 isoform 1	149	ELMO.				phagocytosis	cytoskeleton	GTPase activator activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		AGCCCAATACTCCACTGGAAT	0.383													A	107518220	A	A	107518220	2	1	149	1	0	0	0	0	0	0	0	1	5068	1538	54	5		5	ELMOD1	11	107518220	Silent	SNP	T	TCGA-16-0861-01A-01W-0424-08	31353805	107518220	27488296	40	10237											
WNK1	65125	broad.mit.edu	37	chr12	998382	998382	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgatcacagtgacttctgCggttggtgtaagttttgaaa	12	5	2	3			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr12:998382C>T	uc001qio.3	+	21	5948	c.5441C>T	c.(5440-5442)GCG>GTG	p.A1814V	WNK1_uc001qip.3_Missense_Mutation_p.A1567V|WNK1_uc001qir.3_Missense_Mutation_p.A987V	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1814					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GTGACTTCTGCGGTTGGTGTA	0.368													T	998382	T	T	998382	3	4	149	1	0	0	0	0	1	0	0	0	17374	768	27	1	7025	1	WNK1	12	998382	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08		998382	132853513	41	10238											
RERG	85004	broad.mit.edu	37	chr12	15262109	15262109	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcgtggtggagctgcgtcGcctcgtcttgccctgcacca	13	14	1	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr12:15262109G>A	uc001rcs.2	-	4	675	c.535C>T	c.(535-537)CGA>TGA	p.R179*	RERG_uc001rct.2_Nonsense_Mutation_p.R179*|RERG_uc010shu.1_Nonsense_Mutation_p.R160*	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	179					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						GAGCTGCGTCGCCTCGTCTTG	0.532													A	15262109	A	A	15262109	4	1	149	1	0	0	0	0	0	1	0	0	13232	1095	38	1	68	1	RERG	12	15262109	Nonsense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	14263727	15262109	118589786	42	10239											
AVPR1A	552	broad.mit.edu	37	chr12	63543857	63543857	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgcacccttgctctggcGcgacgccgtcttcccgcgga	11	18	3	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr12:63543857G>A	uc001sro.1	-	1	2734	c.760C>T	c.(760-762)CGC>TGC	p.R254C		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	254	Cytoplasmic (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	TTGCTCTGGCGCGACGCCGTC	0.617													A	63543857	A	A	63543857	3	1	149	1	0	0	0	0	1	0	0	0	1231	1087	38	1	504	1	AVPR1A	12	63543857	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	48281748	63543857	70308038	43	10240											
SYT1	6857	broad.mit.edu	37	chr12	79693293	79693293	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tggattttggccatgtaactGaggaatggcgtgacctgcaa	13	7	0	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr12:79693293G>T	uc001sys.2	+	9	1443	c.772G>T	c.(772-774)GAG>TAG	p.E258*	SYT1_uc001syt.2_Nonsense_Mutation_p.E258*|SYT1_uc001syu.2_Nonsense_Mutation_p.E255*|SYT1_uc001syv.2_Nonsense_Mutation_p.E258*	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	258	Cytoplasmic (Potential).|Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CCATGTAACTGAGGAATGGCG	0.418													T	79693293	T	T	79693293	4	4	149	1	0	0	0	0	0	1	0	0	15462	1291	45	5	790	5	SYT1	12	79693293	Nonsense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	16149436	79693293	54158602	44	10241											
KSR2	283455	broad.mit.edu	37	chr12	118198971	118198971	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgttcttcttcctcatgggCggcgtgcccggcggggtcac	14	13	4	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr12:118198971C>T	uc001two.2	-	4	799	c.744G>A	c.(742-744)CCG>CCA	p.P248P		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	277	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCTCATGGGCGGCGTGCCCG	0.701													T	118198971	T	T	118198971	2	4	149	1	0	0	0	0	0	0	0	1	8582	755	27	1		1	KSR2	12	118198971	Silent	SNP	C	TCGA-16-0861-01A-01W-0424-08	38505678	118198971	15652924	45	10242											
ZNF268	10795	broad.mit.edu	37	chr12	133780200	133780200	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agagaaaccctatagttgtaAtgaatgtggaaaagccttta	9	5	0	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr12:133780200A>G	uc010tcf.1	+	6	2258	c.1928A>G	c.(1927-1929)AAT>AGT	p.N643S	ZNF268_uc010tbv.1_Missense_Mutation_p.N482S|ZNF268_uc010tbw.1_Missense_Mutation_p.N482S|ZNF268_uc010tbx.1_Missense_Mutation_p.N503S|ZNF268_uc010tby.1_Missense_Mutation_p.N482S|ZNF268_uc010tbz.1_Missense_Mutation_p.N482S|ZNF268_uc010tca.1_Missense_Mutation_p.N482S|ZNF268_uc010tcb.1_Missense_Mutation_p.N503S|ZNF268_uc010tcc.1_Missense_Mutation_p.N482S|ZNF268_uc010tcd.1_Missense_Mutation_p.N482S|ZNF268_uc010tce.1_Missense_Mutation_p.N482S|ZNF268_uc010tcg.1_Missense_Mutation_p.N482S|ZNF268_uc010tch.1_Missense_Mutation_p.N643S	NM_003415	NP_003406	Q14587	ZN268_HUMAN	zinc finger protein 268 isoform a	643	C2H2-type 14.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TATAGTTGTAATGAATGTGGA	0.383													G	133780200	G	G	133780200	3	3	149	1	0	0	0	0	1	0	0	0	17804	101	4	4		4	ZNF268	12	133780200	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08	15581229	133780200	71695	46	10243											
MTUS2	23281	broad.mit.edu	37	chr13	29675102	29675102	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagagcagggccggccagCcacccgtaagtggggtgggg	19	12	0	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr13:29675102C>T	uc001usl.3	+	3	2727	c.2669C>T	c.(2668-2670)GCC>GTC	p.A890V		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	880	Sufficient for interaction with KIF2C.|Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						GGCCGGCCAGCCACCCGTAAG	0.582													T	29675102	T	T	29675102	3	4	149	1	0	0	0	0	1	0	0	0	9966	739	26	3	2679	3	MTUS2	13	29675102	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08		29675102	85494776	47	10244											
PDS5B	23047	broad.mit.edu	37	chr13	33327545	33327545	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cccgtttacggcttccacttGagtatatggcaatctgtgcc	9	12	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr13:33327545G>C	uc010abf.2	+	25	2970	c.2812G>C	c.(2812-2814)GAG>CAG	p.E938Q	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	938					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		GCTTCCACTTGAGTATATGGC	0.413													C	33327545	C	C	33327545	3	2	149	1	0	0	0	0	1	0	0	0	11692	1291	45	5	2906	5	PDS5B	13	33327545	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	3652443	33327545	81842333	48	10245											
GPR180	160897	broad.mit.edu	37	chr13	95275364	95275364	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tattgtttttcttttgcagaGtgttttgctactttgggaac	9	5	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr13:95275364G>C	uc001vly.2	+	7	974	c.896G>C	c.(895-897)AGT>ACT	p.S299T	GPR180_uc001vlz.2_Missense_Mutation_p.S198T|GPR180_uc010afi.2_Missense_Mutation_p.S60T	NM_180989	NP_851320	Q86V85	GP180_HUMAN	G protein-coupled receptor 180 precursor	299	Helical; (Potential).					integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					CTTTTGCAGAGTGTTTTGCTA	0.299													C	95275364	C	C	95275364	3	2	149	1	0	0	0	0	1	0	0	0	6676	1043	36	5	922	5	GPR180	13	95275364	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	61947819	95275364	19894514	49	10246											
GZMB	3002	broad.mit.edu	37	chr14	25101153	25101153	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	taagtcagattcgcactttcGatcttcctgcactgtcatct	6	12	4	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr14:25101153G>A	uc001wps.2	-	4	577	c.511C>T	c.(511-513)CGA>TGA	p.R171*	GZMB_uc010ama.2_Nonsense_Mutation_p.R159*|GZMB_uc010amb.2_RNA	NM_004131	NP_004122	P10144	GRAB_HUMAN	granzyme B precursor	171	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.028)		TCGCACTTTCGATCTTCCTGC	0.517													A	25101153	A	A	25101153	4	1	149	1	0	0	0	0	0	1	0	0	6916	1066	37	2	240	2	GZMB	14	25101153	Nonsense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08		25101153	82248387	50	10247											
HEATR5A	25938	broad.mit.edu	37	chr14	31852819	31852835	+	Frame_Shift_Del	DEL	GTGAAGACTTATGTCCA	-	-													gaagccagtcactgcttcagGtgaagacttatgtccagtaa							TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr14:31852819_31852835delGTGAAGACTTATGTCCA	uc001wrf.3	-	4	686_702	c.609_625delTGGACATAAGTCTTCAC	c.(607-627)ACTGGACATAAGTCTTCACCTfs	p.T203fs	HEATR5A_uc010ami.2_Frame_Shift_Del_p.T101fs|HEATR5A_uc001wrg.1_Frame_Shift_Del_p.T85fs|HEATR5A_uc010tpk.1_Frame_Shift_Del_p.T496fs	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	490_496							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		ACTGCTTCAGGTGAAGACTTATGTCCAGTAAGCCGTT	0.461													-	31852835	-	-	31852819	7	5	149	1	0	1	0	1	0	0	0	0	7031	1261	44	0	4744	0	HEATR5A	14	31852819	Frame_Shift_Del	DEL	GTGAAGACTTATGTCCA	TCGA-16-0861-01A-01W-0424-08	6751666	31852819	75496721	51	10248											
NIN	51199	broad.mit.edu	37	chr14	51239167	51239167	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgatgaggttgtggtacgtCgtccactctcatcgaaagac	11	10	1	3			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr14:51239167C>T	uc001wym.2	-	9	1024	c.833G>A	c.(832-834)CGA>CAA	p.R278Q	NIN_uc001wyi.2_Missense_Mutation_p.R278Q|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.R278Q|NIN_uc010tqp.1_Missense_Mutation_p.R284Q|NIN_uc001wyo.2_Missense_Mutation_p.R278Q|NIN_uc001wyp.1_Missense_Mutation_p.R240Q	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	278					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TGTGGTACGTCGTCCACTCTC	0.498			T	PDGFRB	MPD								T	51239167	T	T	51239167	3	4	149	1	0	0	0	0	1	0	0	0	10417	884	31	2	5808	2	NIN	14	51239167	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	19386348	51239167	56110373	52	10249											
SMEK1	55671	broad.mit.edu	37	chr14	91948148	91948148	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgttttcgtggttgtgataaAgcaggatcatattctaaaca	9	5	2	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr14:91948148A>G	uc001xzn.2	-	4	1509	c.687T>C	c.(685-687)GCT>GCC	p.A229A	SMEK1_uc001xzm.2_Silent_p.A229A|SMEK1_uc001xzo.2_Silent_p.A229A|SMEK1_uc010atz.2_Intron|SMEK1_uc001xzp.1_RNA|SMEK1_uc001xzq.1_Silent_p.A105A	NM_032560	NP_115949	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1	229						microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		GTTGTGATAAAGCAGGATCAT	0.353													G	91948148	G	G	91948148	2	3	149	1	0	0	0	0	0	0	0	1	14793	59	3	4		4	SMEK1	14	91948148	Silent	SNP	A	TCGA-16-0861-01A-01W-0424-08	40708981	91948148	15401392	53	10250											
C15orf2	23742	broad.mit.edu	37	chr15	24921847	24921847	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcagcagaagttggctgCggaagtgctgaatgaagagc	16	7	0	4			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr15:24921847C>T	uc001ywo.2	+	1	1307	c.833C>T	c.(832-834)GCG>GTG	p.A278V		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	278					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AAGTTGGCTGCGGAAGTGCTG	0.602													T	24921847	T	T	24921847	3	4	149	1	0	0	0	0	1	0	0	0	1784	768	27	1	835	1	C15orf2	15	24921847	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08		24921847	77609545	54	10251											
MAPKBP1	23005	broad.mit.edu	37	chr15	42109162	42109162	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgatccatgtgctggatgCcgggcgggagtacagcctac	15	11	0	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr15:42109162C>T	uc001zok.3	+	15	1944	c.1658C>T	c.(1657-1659)GCC>GTC	p.A553V	MAPKBP1_uc001zoj.3_Missense_Mutation_p.A547V|MAPKBP1_uc010bcj.2_Missense_Mutation_p.A54V|MAPKBP1_uc010bci.2_Missense_Mutation_p.A547V|MAPKBP1_uc010udb.1_Missense_Mutation_p.A386V|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_Missense_Mutation_p.A54V	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	553	WD 8.									central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GTGCTGGATGCCGGGCGGGAG	0.582													T	42109162	T	T	42109162	3	4	149	1	0	0	0	0	1	0	0	0	9292	739	26	3	1712	3	MAPKBP1	15	42109162	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	17187315	42109162	60422230	55	10252											
TLN2	83660	broad.mit.edu	37	chr15	63127965	63127965	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccctgccaatgctgcagaCgacggacagtggtcacaggg	13	12	1	1	rs139730009		TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr15:63127965C>T	uc002alb.3	+	53	7158	c.7158C>T	c.(7156-7158)GAC>GAT	p.D2386D	TLN2_uc002alc.3_Silent_p.D779D|TLN2_uc010uic.1_Translation_Start_Site|uc002ale.1_5'Flank	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2386	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						ATGCTGCAGACGACGGACAGT	0.597													T	63127965	T	T	63127965	2	4	149	1	0	0	0	0	0	0	0	1	15945	535	19	1		1	TLN2	15	63127965	Silent	SNP	C	TCGA-16-0861-01A-01W-0424-08	21018803	63127965	39403427	56	10253											
SV2B	9899	broad.mit.edu	37	chr15	91811770	91811770	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttttggtgagcatgtgtaCggcgccacaatcaacttcac	9	10	2	1	rs140230861		TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr15:91811770C>T	uc002bqv.2	+	8	1699	c.1308C>T	c.(1306-1308)TAC>TAT	p.Y436Y	SV2B_uc002bqt.2_Silent_p.Y436Y|SV2B_uc010uqv.1_Silent_p.Y285Y|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	436	Extracellular (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			AGCATGTGTACGGCGCCACAA	0.418													T	91811770	T	T	91811770	2	4	149	1	0	0	0	0	0	0	0	1	15415	547	19	1		1	SV2B	15	91811770	Silent	SNP	C	TCGA-16-0861-01A-01W-0424-08	28683805	91811770	10719622	57	10254											
ATXN2L	11273	broad.mit.edu	37	chr16	28844550	28844550	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcggataaggaggacaaaccAcccctggcaccatcaggagg	12	12	1	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr16:28844550A>T	uc002drc.2	+	14	1998	c.1830A>T	c.(1828-1830)CCA>CCT	p.P610P	uc010vct.1_Intron|ATXN2L_uc010byl.1_Silent_p.P586P|ATXN2L_uc002drb.2_Silent_p.P610P|ATXN2L_uc002dqy.2_Silent_p.P610P|ATXN2L_uc002dra.2_Silent_p.P610P|ATXN2L_uc002dqz.2_Silent_p.P610P|ATXN2L_uc010vdb.1_Silent_p.P616P|ATXN2L_uc002dre.2_Silent_p.P610P|ATXN2L_uc002drf.2_Silent_p.P19P|ATXN2L_uc002drg.2_5'Flank	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	610						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						AGGACAAACCACCCCTGGCAC	0.592													T	28844550	T	T	28844550	2	4	149	1	0	0	0	0	0	0	0	1	1212	146	6	5		5	ATXN2L	16	28844550	Silent	SNP	A	TCGA-16-0861-01A-01W-0424-08		28844550	61510203	58	10255											
CCDC135	84229	broad.mit.edu	37	chr16	57741548	57741548	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gaaagcctgtggaaccacaaGaactactggatcaacatgca	9	10	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr16:57741548G>A	uc002emi.2	+	7	1124	c.1035G>A	c.(1033-1035)AAG>AAA	p.K345K	CCDC135_uc002emj.2_Silent_p.K345K|CCDC135_uc002emk.2_Silent_p.K280K	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	345						cytoplasm				central_nervous_system(1)	1						GGAACCACAAGAACTACTGGA	0.552													A	57741548	A	A	57741548	2	1	149	1	0	0	0	0	0	0	0	1	2769	933	33	3		3	CCDC135	16	57741548	Silent	SNP	G	TCGA-16-0861-01A-01W-0424-08	28896998	57741548	32613205	59	10256											
GUCY2D	3000	broad.mit.edu	37	chr17	7909994	7909994	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atcagcacccggacctgaccCctcgtgctggttcgatccaa	9	16	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr17:7909994C>G	uc002gjt.2	+	4	1414	c.1340C>G	c.(1339-1341)CCC>CGC	p.P447R		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	447	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				GGACCTGACCCCTCGTGCTGG	0.612													G	7909994	G	G	7909994	3	3	149	1	0	0	0	0	1	0	0	0	6897	623	22	5	1350	5	GUCY2D	17	7909994	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08		7909994	73285216	60	10257											
HS3ST3A1	9955	broad.mit.edu	37	chr17	13400013	13400013	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggtcaccgggtcccgcaccAccacgatgagcttggtgtcc	12	15	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr17:13400013A>G	uc002gob.1	-	2	1520	c.722T>C	c.(721-723)GTG>GCG	p.V241A		NM_006042	NP_006033	Q9Y663	HS3SA_HUMAN	heparan sulfate D-glucosaminyl	241	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			ovary(1)|central_nervous_system(1)	2		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTCCCGCACCACCACGATGAG	0.632													G	13400013	G	G	13400013	3	3	149	1	0	0	0	0	1	0	0	0	7365	159	6	4	502	4	HS3ST3A1	17	13400013	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08	5490019	13400013	67795197	61	10258											
MRC2	9902	broad.mit.edu	37	chr17	60757258	60757258	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttggcgctggagcgacggcGtaggggtgagggggcctggg	24	7	0	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr17:60757258G>A	uc002jad.2	+	14	2695	c.2293G>A	c.(2293-2295)GTA>ATA	p.V765I	MRC2_uc010ddq.1_RNA|MRC2_uc002jae.2_5'Flank|MRC2_uc002jaf.2_5'Flank	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	765	Extracellular (Potential).|C-type lectin 4.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GAGCGACGGCGTAGGGGTGAG	0.662													A	60757258	A	A	60757258	3	1	149	1	0	0	0	0	1	0	0	0	9758	1145	40	1	2347	1	MRC2	17	60757258	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	47357245	60757258	20437952	62	10259											
ARHGAP28	79822	broad.mit.edu	37	chr18	6894892	6894892	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accctcggcaagacgaatggTaagaaaaataatttcttttc	7	8	1	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr18:6894892T>C	uc010wzi.1	+	14	1612	c.1374_splice	c.e14+2	p.M458_splice	ARHGAP28_uc002knc.2_Splice_Site_p.M583_splice|ARHGAP28_uc002knd.2_Splice_Site_p.M476_splice|ARHGAP28_uc002kne.2_Splice_Site_p.M476_splice|ARHGAP28_uc002knf.2_Splice_Site_p.M467_splice			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;						signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				AGACGAATGGTAAGAAAAATA	0.289													C	6894892	C	C	6894892	5	2	149	1	0	0	0	0	0	0	1	0	877	1652	57	4	1480	4	ARHGAP28	18	6894892	Splice_Site	SNP	T	TCGA-16-0861-01A-01W-0424-08		6894892	71182356	63	10260											
KIAA0802	23255	broad.mit.edu	37	chr18	8783917	8783917	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccttcggtgactccctggaGtcctccactgagctccgccg	10	18	0	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr18:8783917G>C	uc002knr.2	+	6	949	c.807G>C	c.(805-807)GAG>GAC	p.E269D	KIAA0802_uc002knq.2_Missense_Mutation_p.E269D|KIAA0802_uc010dkw.1_Missense_Mutation_p.E107D	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	620	Potential.										0						ACTCCCTGGAGTCCTCCACTG	0.637													C	8783917	C	C	8783917	3	2	149	1	0	0	0	0	1	0	0	0	8194	1020	36	5	821	5	KIAA0802	18	8783917	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	1889025	8783917	69293331	64	10261											
CIDEA	1149	broad.mit.edu	37	chr18	12274219	12274219	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgtgaaggccaccatgtatgAgatgtactccgtgtcctacg	11	11	0	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr18:12274219A>T	uc002kqt.3	+	4	523	c.458A>T	c.(457-459)GAG>GTG	p.E153V	CIDEA_uc002kqu.3_Missense_Mutation_p.E187V|CIDEA_uc010dlc.2_RNA	NM_001279	NP_001270	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a isoform	153					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			ovary(1)|central_nervous_system(1)	2						ACCATGTATGAGATGTACTCC	0.587													T	12274219	T	T	12274219	3	4	149	1	0	0	0	0	1	0	0	0	3425	304	11	5	616	5	CIDEA	18	12274219	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08	3490302	12274219	65803029	65	10262											
DSC1	1823	broad.mit.edu	37	chr18	28736015	28736015	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaaatgcacctgctgaacGtgttgtggaaatggacccaa	12	8	0	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr18:28736015G>A	uc002kwn.2	-	4	724	c.462C>T	c.(460-462)CAC>CAT	p.H154H	DSC1_uc002kwm.2_Silent_p.H154H	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	154	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CCTGCTGAACGTGTTGTGGAA	0.403													A	28736015	A	A	28736015	2	1	149	1	0	0	0	0	0	0	0	1	4765	1136	40	1		1	DSC1	18	28736015	Silent	SNP	G	TCGA-16-0861-01A-01W-0424-08	16461796	28736015	49341233	66	10263											
DCC	1630	broad.mit.edu	37	chr18	50977004	50977004	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatcgtggctgtgatttgcAcccgacgctcttcagcccag	10	14	3	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr18:50977004A>C	uc002lfe.1	+	23	3951	c.3364A>C	c.(3364-3366)ACC>CCC	p.T1122P	DCC_uc010dpf.1_Missense_Mutation_p.T757P	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1122	Helical; (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGTGATTTGCACCCGACGCTC	0.483													C	50977004	C	C	50977004	3	2	149	1	0	0	0	0	1	0	0	0	4282	159	6	5	3454	5	DCC	18	50977004	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08	22240989	50977004	27100244	67	10264											
ZFR2	23217	broad.mit.edu	37	chr19	3825268	3825268	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccacgggtctcttggccagCgctggcctgctcgaggcaca	14	15	1	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr19:3825268C>T	uc002lyw.2	-	7	1185	c.1173G>A	c.(1171-1173)GCG>GCA	p.A391A	ZFR2_uc010xhx.1_Intron	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	391						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		TCTTGGCCAGCGCTGGCCTGC	0.672													T	3825268	T	T	3825268	2	4	149	1	0	0	0	0	0	0	0	1	17657	755	27	1		1	ZFR2	19	3825268	Silent	SNP	C	TCGA-16-0861-01A-01W-0424-08		3825268	55303715	68	10265											
INSR	3643	broad.mit.edu	37	chr19	7184472	7184472	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaagttcacacagcgccagtCctggaagtggtagtacgggg	15	9	1	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr19:7184472C>T	uc002mgd.1	-	3	938	c.829G>A	c.(829-831)GAC>AAC	p.D277N	INSR_uc002mge.1_Missense_Mutation_p.D277N|INSR_uc002mgf.2_Missense_Mutation_p.D277N	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	277	Cys-rich.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAGCGCCAGTCCTGGAAGTGG	0.602													T	7184472	T	T	7184472	3	4	149	1	0	0	0	0	1	0	0	0	7773	855	30	3	3399	3	INSR	19	7184472	Missense_Mutation	SNP	C	TCGA-16-0861-01A-01W-0424-08	3359204	7184472	51944511	69	10266											
RAB11B	9230	broad.mit.edu	37	chr19	8468383	8468383	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaacgtggtggacatcagcGtgccgcccaccacggacgga	13	14	1	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr19:8468383G>A	uc002mju.3	+	5	694	c.598G>A	c.(598-600)GTG>ATG	p.V200M		NM_004218	NP_004209	Q15907	RB11B_HUMAN	RAB11B, member RAS oncogene family	200					cell cycle|protein transport|small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity				0						GGACATCAGCGTGCCGCCCAC	0.647													A	8468383	A	A	8468383	3	1	149	1	0	0	0	0	1	0	0	0	12892	1145	40	1	616	1	RAB11B	19	8468383	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	1283911	8468383	50660600	70	10267											
ZNF527	84503	broad.mit.edu	37	chr19	37879435	37879435	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aaatctctactgggaaaagaGacaatgaatttagtaattct	7	5	2	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr19:37879435G>C	uc010efk.1	+	5	595	c.484G>C	c.(484-486)GAC>CAC	p.D162H	ZNF527_uc002ogf.3_Missense_Mutation_p.D130H|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGGGAAAAGAGACAATGAATT	0.378													C	37879435	C	C	37879435	3	2	149	1	0	0	0	0	1	0	0	0	17965	942	33	5	498	5	ZNF527	19	37879435	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08	29411052	37879435	21249548	71	10268											
GSS	2937	broad.mit.edu	37	chr20	33516696	33516696	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	accaccatctgcatgctcgaTggctttggttcgaagtagat	10	10	1	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr20:33516696T>A	uc002xbg.2	-	13	1440	c.1360A>T	c.(1360-1362)ATC>TTC	p.I454F	GSS_uc010zun.1_Missense_Mutation_p.I326F|GSS_uc010zuo.1_Missense_Mutation_p.I343F|GSS_uc010zup.1_Missense_Mutation_p.I385F|GSS_uc002xbh.2_RNA	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	454					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	GCATGCTCGATGGCTTTGGTT	0.562													A	33516696	A	A	33516696	3	1	149	1	0	0	0	0	1	0	0	0	6829	1464	51	5	68	5	GSS	20	33516696	Missense_Mutation	SNP	T	TCGA-16-0861-01A-01W-0424-08		33516696	29508824	72	10269											
MED15	51586	broad.mit.edu	37	chr22	20939408	20939408	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccccagtggtgtgcacccGgaagcgcaggcttgaggatg	17	11	0	1			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr22:20939408G>A	uc002zsp.2	+	16	2065	c.1985G>A	c.(1984-1986)CGG>CAG	p.R662Q	MED15_uc002zsq.2_Missense_Mutation_p.R622Q|MED15_uc010gso.2_Missense_Mutation_p.R605Q|MED15_uc002zsr.2_Missense_Mutation_p.R596Q|MED15_uc011ahs.1_Missense_Mutation_p.R596Q|MED15_uc002zss.2_Missense_Mutation_p.R541Q|MED15_uc011ahu.1_Missense_Mutation_p.R372Q|MED15_uc002zst.2_Missense_Mutation_p.R278Q|MED15_uc002zsu.2_Missense_Mutation_p.R267Q	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	662					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			GTGTGCACCCGGAAGCGCAGG	0.682													A	20939408	A	A	20939408	3	1	149	1	0	0	0	0	1	0	0	0	9433	1116	39	2	2047	2	MED15	22	20939408	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08		20939408	30365158	73	10270											
NCAPH2	29781	broad.mit.edu	37	chr22	50956414	50956414	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccatgcaggaggtcctcatcAtccccctcctgcccatggcc	8	19	2	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chr22:50956414A>G	uc003blr.3	+	6	555	c.433A>G	c.(433-435)ATC>GTC	p.I145V	NCAPH2_uc003blq.3_Missense_Mutation_p.I145V|NCAPH2_uc003blv.2_Missense_Mutation_p.I145V|NCAPH2_uc010hbb.2_5'UTR|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.I145V|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	145					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		GGTCCTCATCATCCCCCTCCT	0.612													G	50956414	G	G	50956414	3	3	149	1	0	0	0	0	1	0	0	0	10210	217	8	4	455	4	NCAPH2	22	50956414	Missense_Mutation	SNP	A	TCGA-16-0861-01A-01W-0424-08	30017006	50956414	348152	74	10271											
F9	2158	broad.mit.edu	37	chrX	138643014	138643014	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttaaaattacagttgtcgcaGgtaaatacacagaaagaata	7	5	0	2			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chrX:138643014G>A	uc004fas.1	+	7	867	c.838G>A	c.(838-840)GGT>AGT	p.G280S	F9_uc004fat.1_Missense_Mutation_p.G242S	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	280	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	AGTTGTCGCAGGTAAATACAC	0.343													A	138643014	A	A	138643014	3	1	149	1	0	0	0	0	1	0	0	0	5351	1014	35	3	864	3	F9	23	138643014	Missense_Mutation	SNP	G	TCGA-16-0861-01A-01W-0424-08		138643014	16627546	75	10272											
ATP11C	286410	broad.mit.edu	37	chrX	138864837	138864837	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtctgttaattctttcataAtcatctggagcaatttcttt	5	7	6	0			TCGA-16-0861-01A-01W-0424-08	TCGA-16-0861-10A-01W-0424-08									Somatic	Phase_I	Capture				Illumina GAIIx	deab6efd-8213-4f35-a897-060c605ce58b	882b9e64-c667-4e1a-ad98-67efd518b42b	g.chrX:138864837A>G	uc004faz.2	-	18	1929	c.1830T>C	c.(1828-1830)GAT>GAC	p.D610D	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Silent_p.D610D	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	610	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TTCTTTCATAATCATCTGGAG	0.353													G	138864837	G	G	138864837	2	3	149	1	0	0	0	0	0	0	0	1	1121	98	4	4		4	ATP11C	23	138864837	Silent	SNP	A	TCGA-16-0861-01A-01W-0424-08	221823	138864837	16405723	76	10273											
DMBX1	127343	broad.mit.edu	37	chr1	46972778	46972778	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggcagcccagcaggcccaGcatgcccccgactaccggcc	11	20	0	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:46972778G>A	uc001cpx.2	+	1	111	c.96G>A	c.(94-96)CAG>CAA	p.Q32Q	DMBX1_uc001cpw.2_Silent_p.Q32Q	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	32	Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AGCAGGCCCAGCATGCCCCCG	0.642													A	46972778	A	A	46972778	2	1	150	1	0	0	0	0	0	0	0	1	4578	962	34	3		3	DMBX1	1	46972778	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08		46972778	202277843	1	10274											
ZCCHC11	23318	broad.mit.edu	37	chr1	52981638	52981638	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cccagcctctgctcaggtgtCaatgcagattcatctatcac	7	14	6	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:52981638C>G	uc001ctx.2	-	3	1041	c.807G>C	c.(805-807)TTG>TTC	p.L269F	ZCCHC11_uc001cty.2_Missense_Mutation_p.L269F|ZCCHC11_uc001ctz.2_Missense_Mutation_p.L269F|ZCCHC11_uc009vze.1_Missense_Mutation_p.L269F|ZCCHC11_uc009vzf.1_Missense_Mutation_p.L28F|ZCCHC11_uc001cub.2_Missense_Mutation_p.L269F|ZCCHC11_uc001cuc.2_RNA|ZCCHC11_uc001cud.2_Missense_Mutation_p.L269F	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	269					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						GCTCAGGTGTCAATGCAGATT	0.343													G	52981638	G	G	52981638	3	3	150	1	0	0	0	0	1	0	0	0	17577	825	29	5	4242	5	ZCCHC11	1	52981638	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	6008860	52981638	196268983	2	10275											
LRRC7	57554	broad.mit.edu	37	chr1	70477511	70477511	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagaagaatttgactgtagcTgtaatgaactggagtcacta	10	5	1	4			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:70477511T>C	uc001dep.2	+	10	952	c.922T>C	c.(922-924)TGT>CGT	p.C308R	LRRC7_uc009wbg.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	308	LRR 13.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TGACTGTAGCTGTAATGAACT	0.328													C	70477511	C	C	70477511	3	2	150	1	0	0	0	0	1	0	0	0	9020	1580	55	4	960	4	LRRC7	1	70477511	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	17495873	70477511	178773110	3	10276											
FAM46C	54855	broad.mit.edu	37	chr1	118166577	118166577	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actaccagccggccccttacGtcagtgatggcaacttcagc	9	15	2	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:118166577G>A	uc001ehe.2	+	2	1286	c.1087G>A	c.(1087-1089)GTC>ATC	p.V363I		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	363											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		GGCCCCTTACGTCAGTGATGG	0.557										Multiple Myeloma(3;1.13e-06)			A	118166577	A	A	118166577	3	1	150	1	0	0	0	0	1	0	0	0	5567	1145	40	1	1089	1	FAM46C	1	118166577	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	47689066	118166577	131084044	4	10277											
RGS4	5999	broad.mit.edu	37	chr1	163044147	163044147	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaccagggaagagacaagcCggaacatgctagagcctaca	12	11	0	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:163044147C>T	uc009wuy.2	+	5	926	c.415C>T	c.(415-417)CGG>TGG	p.R139W	RGS4_uc001gcl.3_Missense_Mutation_p.R236W|RGS4_uc009wuz.2_Missense_Mutation_p.P83L|RGS4_uc009wva.2_Missense_Mutation_p.R121W	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2	139	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						AGAGACAAGCCGGAACATGCT	0.507													T	163044147	T	T	163044147	3	4	150	1	0	0	0	0	1	0	0	0	13307	652	23	2	728	2	RGS4	1	163044147	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	44877570	163044147	86206474	5	10278											
C1orf112	55732	broad.mit.edu	37	chr1	169811564	169811564	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttctgtccttcagaacacaGtactgtctgctttgcttgca	7	11	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:169811564G>A	uc001ggp.2	+	19	2042	c.1732G>A	c.(1732-1734)GTA>ATA	p.V578I	C1orf112_uc001ggj.2_RNA|C1orf112_uc001ggq.2_Missense_Mutation_p.V578I|C1orf112_uc009wvt.2_Missense_Mutation_p.V255I|C1orf112_uc009wvu.1_Missense_Mutation_p.V454I|C1orf112_uc001ggr.2_Missense_Mutation_p.V443I|C1orf112_uc010plv.1_Missense_Mutation_p.V520I	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	hypothetical protein LOC55732	578											0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCAGAACACAGTACTGTCTGC	0.403													A	169811564	A	A	169811564	3	1	150	1	0	0	0	0	1	0	0	0	1985	1029	36	3	1794	3	C1orf112	1	169811564	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	6767417	169811564	79439057	6	10279											
CEP350	9857	broad.mit.edu	37	chr1	180063490	180063490	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaaaacaacaactggaaaaAatcagcttactgacagacag	6	9	2	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:180063490A>G	uc001gnt.2	+	34	8633	c.8250A>G	c.(8248-8250)AAA>AAG	p.K2750K	CEP350_uc009wxl.2_Silent_p.K2749K|CEP350_uc001gnv.2_Silent_p.K885K|CEP350_uc001gnw.1_Silent_p.K507K|CEP350_uc001gnx.1_Silent_p.K507K	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2750	Potential.					centrosome|nucleus|spindle				ovary(4)	4						AACTGGAAAAAATCAGCTTAC	0.358													G	180063490	G	G	180063490	2	3	150	1	0	0	0	0	0	0	0	1	3254	11	1	4		4	CEP350	1	180063490	Silent	SNP	A	TCGA-16-1045-01B-01W-0611-08	10251926	180063490	69187131	7	10280											
CACNA1E	777	broad.mit.edu	37	chr1	181479699	181479699	+	Frame_Shift_Del	DEL	C	-	-													tcttcctgaggatgacaagaCccccatgtcccgaagactgg							TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:181479699delC	uc001gow.2	+	2	518	c.353delC	c.(352-354)ACCfs	p.T118fs	CACNA1E_uc009wxr.2_Frame_Shift_Del_p.T25fs|CACNA1E_uc009wxs.2_Frame_Shift_Del_p.T25fs	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	118	I.|Extracellular (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GATGACAAGACCCCCATGTCC	0.527													-	181479699	-	-	181479699	7	5	150	1	0	1	0	1	0	0	0	0	2542	507	18	0	359	0	CACNA1E	1	181479699	Frame_Shift_Del	DEL	C	TCGA-16-1045-01B-01W-0611-08	1416209	181479699	67770922	8	10281											
TPR	7175	broad.mit.edu	37	chr1	186329081	186329081	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttaattcttttgttctctagTttctccaaaagcaactgatc	4	9	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:186329081T>C	uc001grv.2	-	12	1536	c.1239A>G	c.(1237-1239)AAA>AAG	p.K413K	TPR_uc010pop.1_Silent_p.K489K	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	413					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TGTTCTCTAGTTTCTCCAAAA	0.363			T	NTRK1	papillary thyroid								C	186329081	C	C	186329081	2	2	150	1	0	0	0	0	0	0	0	1	16413	1722	60	4		4	TPR	1	186329081	Silent	SNP	T	TCGA-16-1045-01B-01W-0611-08	4849382	186329081	62921540	9	10282											
PTPRC	5788	broad.mit.edu	37	chr1	198608459	198608459	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgcctttctggacacagaaGtatttgtgacaggtaagtac	10	7	1	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:198608459G>T	uc001gur.1	+	2	235	c.55G>T	c.(55-57)GTA>TTA	p.V19L	PTPRC_uc001gus.1_Missense_Mutation_p.V19L|PTPRC_uc001gut.1_Missense_Mutation_p.V19L|PTPRC_uc001guq.2_Missense_Mutation_p.V19L|PTPRC_uc009wze.1_Missense_Mutation_p.V21L|PTPRC_uc009wzf.1_Missense_Mutation_p.V21L|PTPRC_uc010ppg.1_Missense_Mutation_p.V21L|PTPRC_uc001guu.1_Missense_Mutation_p.V21L|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	19					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GGACACAGAAGTATTTGTGAC	0.338													T	198608459	T	T	198608459	3	4	150	1	0	0	0	0	1	0	0	0	12797	1029	36	5	57	5	PTPRC	1	198608459	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	12279378	198608459	50642162	10	10283											
RAB3GAP2	25782	broad.mit.edu	37	chr1	220325030	220325030	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtctgggtgtggagaagcGcatgagccagcctttgcccc	14	11	1	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:220325030G>A	uc010puk.1	-	34	4108	c.3944C>T	c.(3943-3945)GCG>GTG	p.A1315V	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.A895V|RAB3GAP2_uc001hmh.2_Missense_Mutation_p.A259V	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	1315					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		GTGGAGAAGCGCATGAGCCAG	0.507													A	220325030	A	A	220325030	3	1	150	1	0	0	0	0	1	0	0	0	12936	1087	38	1	245	1	RAB3GAP2	1	220325030	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	21716571	220325030	28925591	11	10284											
ZP4	57829	broad.mit.edu	37	chr1	238053168	238053168	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gagagcttccagcctttaccTagaagatccataggacactt	8	11	0	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr1:238053168T>A	uc001hym.2	-	3	399	c.399A>T	c.(397-399)CTA>CTT	p.L133L	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	133	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AGCCTTTACCTAGAAGATCCA	0.547													A	238053168	A	A	238053168	2	1	150	1	0	0	0	0	0	0	0	1	18215	1536	53	5		5	ZP4	1	238053168	Silent	SNP	T	TCGA-16-1045-01B-01W-0611-08	17728138	238053168	11197453	12	10285											
LOXL3	84695	broad.mit.edu	37	chr2	74761513	74761513	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaccttggtgccatttggGgtgaggatatcatagtgagt	14	7	1	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr2:74761513G>A	uc002smp.1	-	11	1941	c.1869C>T	c.(1867-1869)ACC>ACT	p.T623T	LOXL3_uc002smo.1_Silent_p.T262T|LOXL3_uc010ffm.1_Silent_p.T567T|LOXL3_uc002smq.1_Silent_p.T478T|LOXL3_uc010ffn.1_Silent_p.T478T	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	623	Lysyl-oxidase like.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						TGCCATTTGGGGTGAGGATAT	0.527													A	74761513	A	A	74761513	2	1	150	1	0	0	0	0	0	0	0	1	8901	1219	43	3		3	LOXL3	2	74761513	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08		74761513	168437860	13	10286											
CTNNA2	1496	broad.mit.edu	37	chr2	80801323	80801323	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgaacaagtagaggttgccAttgaagccctgagtgccaac	11	10	0	4			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr2:80801323A>T	uc010ysh.1	+	12	1782	c.1777A>T	c.(1777-1779)ATT>TTT	p.I593F	CTNNA2_uc010yse.1_Missense_Mutation_p.I593F|CTNNA2_uc010ysf.1_Missense_Mutation_p.I593F|CTNNA2_uc010ysg.1_Missense_Mutation_p.I593F|CTNNA2_uc010ysi.1_Missense_Mutation_p.I225F	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	593					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGAGGTTGCCATTGAAGCCCT	0.483													T	80801323	T	T	80801323	3	4	150	1	0	0	0	0	1	0	0	0	4013	217	8	5	1615	5	CTNNA2	2	80801323	Missense_Mutation	SNP	A	TCGA-16-1045-01B-01W-0611-08	6039810	80801323	162398050	14	10287											
POTEF	728378	broad.mit.edu	37	chr2	130877801	130877801	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cagcaccacttgcccatcttGttcctgagtgtcttcatagc	7	14	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr2:130877801G>T	uc010fmh.2	-	3	688	c.288C>A	c.(286-288)AAC>AAA	p.N96K		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	96						cell cortex	ATP binding			skin(3)|ovary(2)	5						TGCCCATCTTGTTCCTGAGTG	0.612													T	130877801	T	T	130877801	3	4	150	1	0	0	0	0	1	0	0	0	12265	1368	48	5	2999	5	POTEF	2	130877801	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	50076478	130877801	112321572	15	10288											
POTEE	445582	broad.mit.edu	37	chr2	131976263	131976263	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gctatgaagacactcaggaaCaagatggggaagtggtgctg	15	6	1	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr2:131976263C>A	uc002tsn.2	+	1	340	c.288C>A	c.(286-288)AAC>AAA	p.N96K	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	96							ATP binding				0						CACTCAGGAACAAGATGGGGA	0.617													A	131976263	A	A	131976263	3	1	150	1	0	0	0	0	1	0	0	0	12264	477	17	5	290	5	POTEE	2	131976263	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	1098462	131976263	111223110	16	10289											
RAB3GAP1	22930	broad.mit.edu	37	chr2	135893152	135893155	+	Frame_Shift_Del	DEL	GAAA	-	-													agatgttaaattgttgtattGaaagaaagaaggcacgtgat							TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr2:135893152_135893155delGAAA	uc002tuj.2	+	17	1598_1601	c.1573_1576delGAAA	c.(1573-1578)GAAAGAfs	p.E525fs	RAB3GAP1_uc010fnf.2_Frame_Shift_Del_p.E525fs|RAB3GAP1_uc010fng.2_Frame_Shift_Del_p.E350fs|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	525_526						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		TTGTTGTATTGAAAGAAAGAAGGC	0.333													-	135893155	-	-	135893152	7	5	150	1	0	1	0	1	0	0	0	0	12935	1291	45	0	1639	0	RAB3GAP1	2	135893152	Frame_Shift_Del	DEL	GAAA	TCGA-16-1045-01B-01W-0611-08	3916889	135893152	107306221	17	10290											
TTN	7273	broad.mit.edu	37	chr2	179500424	179500424	+	Frame_Shift_Del	DEL	A	-	-													ggtctcgtataggtttcaccAgccaatctctaatgacttct							TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr2:179500424delA	uc010zfg.1	-	176	34147	c.33923delT	c.(33922-33924)CTGfs	p.L11308fs	TTN_uc010zfh.1_Frame_Shift_Del_p.L5003fs|TTN_uc010zfi.1_Frame_Shift_Del_p.L4936fs|TTN_uc010zfj.1_Frame_Shift_Del_p.L4811fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12235							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGTTTCACCAGCCAATCTCT	0.353													-	179500424	-	-	179500424	7	5	150	1	0	1	0	1	0	0	0	0	16732	188	7	0	66610	0	TTN	2	179500424	Frame_Shift_Del	DEL	A	TCGA-16-1045-01B-01W-0611-08	43607272	179500424	63698949	18	10291											
KLF7	8609	broad.mit.edu	37	chr2	207988812	207988812	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggcggctgagctcaggggacGatgggggcgttaatgaggtc	20	7	1	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr2:207988812G>A	uc002vbz.1	-	2	741	c.419C>T	c.(418-420)TCG>TTG	p.S140L	KLF7_uc002vca.1_Missense_Mutation_p.S140L|KLF7_uc010zix.1_Missense_Mutation_p.S112L	NM_003709	NP_003700	O75840	KLF7_HUMAN	Kruppel-like factor 7 (ubiquitous)	140					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			central_nervous_system(1)|skin(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)		CTCAGGGGACGATGGGGGCGT	0.597													A	207988812	A	A	207988812	3	1	150	1	0	0	0	0	1	0	0	0	8351	1059	37	2	501	2	KLF7	2	207988812	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	28488388	207988812	35210561	19	10292											
DOCK10	55619	broad.mit.edu	37	chr2	225666723	225666723	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaagtttgtgatctgtgctGcttatggccttcatgactgg	11	7	2	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr2:225666723G>A	uc010fwz.1	-	40	4542	c.4303C>T	c.(4303-4305)CAG>TAG	p.Q1435*	DOCK10_uc002vob.2_Nonsense_Mutation_p.Q1429*|DOCK10_uc002voa.2_Nonsense_Mutation_p.Q91*|DOCK10_uc002voc.2_Nonsense_Mutation_p.Q289*	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1435							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GATCTGTGCTGCTTATGGCCT	0.378													A	225666723	A	A	225666723	4	1	150	1	0	0	0	0	0	1	0	0	4685	1328	46	3	2325	3	DOCK10	2	225666723	Nonsense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	17677911	225666723	17532650	20	10293											
CAPN10	11132	broad.mit.edu	37	chr2	241556394	241556394	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgaaactctaccaacagcCacctgggggagctggaagtg	12	10	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr2:241556394C>T	uc002vzq.1	+	4	576	c.399C>T	c.(397-399)GCC>GCT	p.A133A	GPR35_uc010fzh.1_Intron|GPR35_uc010fzi.1_Intron	NM_023089	NP_075577	Q9HC96	CAN10_HUMAN	calpain 10 isoform g	Error:Variant_position_missing_in_Q9HC96_after_alignment					actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		taccaacagccacctggggga	0													T	241556394	T	T	241556394	2	4	150	1	0	0	0	0	0	0	0	1	2623	608	21	3		3	CAPN10	2	241556394	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	15889671	241556394	1642979	21	10294											
IL5RA	3568	broad.mit.edu	37	chr3	3139898	3139898	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagtgaagggaaacttggtaTgaccttaaacgtgaataatt	10	5	0	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr3:3139898T>C	uc011ask.1	-	7	1088	c.444A>G	c.(442-444)TCA>TCG	p.S148S	IL5RA_uc010hbq.2_Silent_p.S148S|IL5RA_uc010hbr.2_Intron|IL5RA_uc010hbs.2_Silent_p.S148S|IL5RA_uc011asl.1_Silent_p.S148S|IL5RA_uc011asm.1_Silent_p.S148S|IL5RA_uc010hbt.2_Silent_p.S148S|IL5RA_uc011asn.1_Silent_p.S148S|IL5RA_uc010hbu.2_Silent_p.S148S	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	148	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		AAACTTGGTATGACCTTAAAC	0.413													C	3139898	C	C	3139898	2	2	150	1	0	0	0	0	0	0	0	1	7700	1451	51	4		4	IL5RA	3	3139898	Silent	SNP	T	TCGA-16-1045-01B-01W-0611-08		3139898	194882532	22	10295											
GADL1	339896	broad.mit.edu	37	chr3	30885739	30885739	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agacttgcttctccagttccTcaggtatcattttacctcta	5	12	4	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr3:30885739T>A	uc003cep.2	-	8	796	c.749A>T	c.(748-750)GAG>GTG	p.E250V	GADL1_uc003ceq.1_Missense_Mutation_p.E250V	NM_207359	NP_997242	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	250					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	CTCCAGTTCCTCAGGTATCAT	0.438													A	30885739	A	A	30885739	3	1	150	1	0	0	0	0	1	0	0	0	6185	1551	54	5	848	5	GADL1	3	30885739	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	27745841	30885739	167136691	23	10296											
FLNB	2317	broad.mit.edu	37	chr3	58135696	58135696	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtgcctggggtttatatcGtctccaccaaattcgctgac	9	13	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr3:58135696G>A	uc003djj.2	+	37	6376	c.6211G>A	c.(6211-6213)GTC>ATC	p.V2071I	FLNB_uc010hne.2_Missense_Mutation_p.V2102I|FLNB_uc003djk.2_Missense_Mutation_p.V2060I|FLNB_uc010hnf.2_Missense_Mutation_p.V2047I|FLNB_uc003djl.2_Missense_Mutation_p.V1891I|FLNB_uc003djm.2_Missense_Mutation_p.V1878I|FLNB_uc010hng.1_RNA	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2071	Interaction with FLNA 1.|Filamin 19.|Interaction with the cytoplasmic tail of GP1BA.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGTTTATATCGTCTCCACCAA	0.562													A	58135696	A	A	58135696	3	1	150	1	0	0	0	0	1	0	0	0	5934	1145	40	1	6454	1	FLNB	3	58135696	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	27249957	58135696	139886734	24	10297											
PHLDB2	90102	broad.mit.edu	37	chr3	111632476	111632476	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actactcagtgacctcacccGgactcctccaccaccatcct	4	20	2	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr3:111632476G>A	uc010hqa.2	+	3	2057	c.1646G>A	c.(1645-1647)CGG>CAG	p.R549Q	PHLDB2_uc003dyc.2_Missense_Mutation_p.R576Q|PHLDB2_uc003dyd.2_Missense_Mutation_p.R549Q|PHLDB2_uc003dyg.2_Missense_Mutation_p.R549Q|PHLDB2_uc003dyh.2_Missense_Mutation_p.R549Q|PHLDB2_uc003dyi.2_Missense_Mutation_p.R135Q|PHLDB2_uc003dyf.3_Missense_Mutation_p.R549Q	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	549						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GACCTCACCCGGACTCCTCCA	0.522													A	111632476	A	A	111632476	3	1	150	1	0	0	0	0	1	0	0	0	11852	1116	39	2	1737	2	PHLDB2	3	111632476	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	53496780	111632476	86389954	25	10298											
PCCB	5096	broad.mit.edu	37	chr3	135980854	135980854	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgaatgactctgggggaGcacggatccaagaaggagtg	17	7	1	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr3:135980854G>A	uc003eqy.1	+	5	541	c.490G>A	c.(490-492)GCA>ACA	p.A164T	PCCB_uc003eqz.1_Missense_Mutation_p.A164T|PCCB_uc011bmc.1_Missense_Mutation_p.A184T|PCCB_uc011bmd.1_Missense_Mutation_p.A81T	NM_000532	NP_000523	P05166	PCCB_HUMAN	propionyl Coenzyme A carboxylase, beta	164	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity				0					Biotin(DB00121)|L-Valine(DB00161)	CTCTGGGGGAGCACGGATCCA	0.458													A	135980854	A	A	135980854	3	1	150	1	0	0	0	0	1	0	0	0	11505	971	34	3	572	3	PCCB	3	135980854	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	24348378	135980854	62041576	26	10299											
MECOM	2122	broad.mit.edu	37	chr3	168845829	168845829	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagagctggtcacagtcttcGcagcgatattgccgttcttc	10	11	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr3:168845829G>A	uc003ffi.3	-	4	338	c.69C>T	c.(67-69)TGC>TGT	p.C23C	MECOM_uc010hwk.1_Silent_p.C46C|MECOM_uc003ffj.3_Silent_p.C87C|MECOM_uc011bpi.1_Silent_p.C23C|MECOM_uc003ffn.3_Silent_p.C23C|MECOM_uc003ffk.2_Silent_p.C23C|MECOM_uc003ffl.2_Silent_p.C183C|MECOM_uc011bpj.1_Silent_p.C211C|MECOM_uc011bpk.1_Silent_p.C13C|MECOM_uc010hwn.2_Silent_p.C211C|MECOM_uc003ffm.1_Silent_p.C87C	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	23	C2H2-type 1.|Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CACAGTCTTCGCAGCGATATT	0.433													A	168845829	A	A	168845829	2	1	150	1	0	0	0	0	0	0	0	1	9422	1079	38	1		1	MECOM	3	168845829	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	32864975	168845829	29176601	27	10300											
MUC4	4585	broad.mit.edu	37	chr3	195498599	195498599	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccagggccacagggtccCggcctgtgaagcctgttggg	15	14	0	1	rs145772547		TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr3:195498599C>T	uc011bto.1	-	6	13242	c.12782G>A	c.(12781-12783)CGG>CAG	p.R4261Q	MUC4_uc003fuz.2_Missense_Mutation_p.G69R|MUC4_uc003fva.2_5'UTR|MUC4_uc003fvb.2_5'UTR|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_5'UTR|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_5'UTR|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_5'UTR|MUC4_uc011bti.1_5'UTR|MUC4_uc011btj.1_Missense_Mutation_p.R130Q|MUC4_uc011btk.1_5'UTR|MUC4_uc011btl.1_5'UTR|MUC4_uc011btm.1_Missense_Mutation_p.R130Q|MUC4_uc011btn.1_5'UTR|MUC4_uc003fvo.2_Missense_Mutation_p.R153Q|MUC4_uc003fvp.2_Missense_Mutation_p.R102Q|MUC4_uc010hzu.1_Missense_Mutation_p.R1001Q	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1146					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CACAGGGTCCCGGCCTGTGAA	0.562													T	195498599	T	T	195498599	3	4	150	1	0	0	0	0	1	0	0	0	9978	652	23	2	3156	2	MUC4	3	195498599	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	26652770	195498599	2523831	28	10301											
SLC10A4	201780	broad.mit.edu	37	chr4	48486116	48486116	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtggctgctgtcccggcGgcaatctctccaatcttatg	11	12	2	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr4:48486116G>A	uc003gyc.2	+	1	757	c.538G>A	c.(538-540)GGC>AGC	p.G180S		NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	180	Helical; (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1						CTGTCCCGGCGGCAATCTCTC	0.632													A	48486116	A	A	48486116	3	1	150	1	0	0	0	0	1	0	0	0	14376	1116	39	2	540	2	SLC10A4	4	48486116	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08		48486116	142668160	29	10302											
YTHDC1	91746	broad.mit.edu	37	chr4	69184554	69184554	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	cccgacttacctgtccacttCctggtatcgtggatccttta	7	14	0	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr4:69184554C>A	uc003hdx.2	-	13	2064	c.1711G>T	c.(1711-1713)GAA>TAA	p.E571*	YTHDC1_uc003hdy.2_Nonsense_Mutation_p.E553*	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	571	Arg-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						CTGTCCACTTCCTGGTATCGT	0.318													A	69184554	A	A	69184554	4	1	150	1	0	0	0	0	0	1	0	0	17493	864	30	5	492	5	YTHDC1	4	69184554	Nonsense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	20698438	69184554	121969722	30	10303											
SGMS2	166929	broad.mit.edu	37	chr4	108831540	108831540	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttcacagactaatttcttatCtcgagcatggtggttcccca	7	11	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr4:108831540C>T	uc003hyl.3	+	7	1484	c.929C>T	c.(928-930)TCT>TTT	p.S310F	uc003hym.1_Intron|SGMS2_uc003hyn.2_Missense_Mutation_p.S310F|SGMS2_uc003hyo.2_Missense_Mutation_p.S310F	NM_001136258	NP_001129730	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	310	Cytoplasmic (Potential).				sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			lung(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	AATTTCTTATCTCGAGCATGG	0.388													T	108831540	T	T	108831540	3	4	150	1	0	0	0	0	1	0	0	0	14215	913	32	3	947	3	SGMS2	4	108831540	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	39646986	108831540	82322736	31	10304											
TBC1D9	23158	broad.mit.edu	37	chr4	141545490	141545490	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtctggctttaggctcacCgtaacaaagccatcatctgc	8	12	4	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr4:141545490C>T	uc010ioj.2	-	19	3224	c.2952G>A	c.(2950-2952)ACG>ACA	p.T984T		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	984						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTAGGCTCACCGTAACAAAGC	0.373													T	141545490	T	T	141545490	2	4	150	1	0	0	0	0	0	0	0	1	15624	639	23	2		2	TBC1D9	4	141545490	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	32713950	141545490	49608786	32	10305											
SLC6A18	348932	broad.mit.edu	37	chr5	1225635	1225635	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acccggccgcctgcgacctcGgggatgagaggcccaagtgg	16	14	0	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr5:1225635G>A	uc003jby.1	+	1	166	c.43G>A	c.(43-45)GGG>AGG	p.G15R		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	15	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTGCGACCTCGGGGATGAGAG	0.642													A	1225635	A	A	1225635	3	1	150	1	0	0	0	0	1	0	0	0	14681	1116	39	2	45	2	SLC6A18	5	1225635	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08		1225635	179689625	33	10306											
LHFPL2	10184	broad.mit.edu	37	chr5	77784877	77784877	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccagcccaaggagcagtctCcaggtttgtaggcagatgca	12	12	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr5:77784877C>T	uc003kfo.2	-	5	1206	c.530G>A	c.(529-531)GGA>GAA	p.G177E		NM_005779	NP_005770	Q6ZUX7	LHPL2_HUMAN	lipoma HMGIC fusion partner-like 2	177						integral to membrane					0		all_lung(232;0.000409)|Lung NSC(167;0.00108)|Ovarian(174;0.0107)|Prostate(461;0.218)		OV - Ovarian serous cystadenocarcinoma(54;6.48e-46)|Epithelial(54;8.43e-42)|all cancers(79;1.42e-36)		GGAGCAGTCTCCAGGTTTGTA	0.512													T	77784877	T	T	77784877	3	4	150	1	0	0	0	0	1	0	0	0	8765	855	30	3	160	3	LHFPL2	5	77784877	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	76559242	77784877	103130383	34	10307											
ARSK	153642	broad.mit.edu	37	chr5	94918696	94918696	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccatggttaatcttatcCgtaacaggactaaagtcaga	9	9	2	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr5:94918696C>T	uc003kld.2	+	4	651	c.493C>T	c.(493-495)CGT>TGT	p.R165C	ARSK_uc010jbg.2_Missense_Mutation_p.R6C|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	165						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		TAATCTTATCCGTAACAGGAC	0.418													T	94918696	T	T	94918696	3	4	150	1	0	0	0	0	1	0	0	0	996	652	23	2	507	2	ARSK	5	94918696	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	17133819	94918696	85996564	35	10308											
PHF15	23338	broad.mit.edu	37	chr5	133902013	133902013	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctggaaaaggtgaccctgCgcaagcagcggctgcagcag	14	12	0	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr5:133902013C>T	uc003kzo.1	+	9	1356	c.1177C>T	c.(1177-1179)CGC>TGC	p.R393C	PHF15_uc011cxt.1_Missense_Mutation_p.R393C|PHF15_uc003kzk.2_Missense_Mutation_p.R409C|PHF15_uc003kzl.2_Missense_Mutation_p.R393C|PHF15_uc003kzm.2_Missense_Mutation_p.R393C|PHF15_uc003kzn.2_Missense_Mutation_p.R393C|PHF15_uc003kzp.2_Missense_Mutation_p.R101C	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	393					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGTGACCCTGCGCAAGCAGCG	0.642													T	133902013	T	T	133902013	3	4	150	1	0	0	0	0	1	0	0	0	11826	768	27	1	1207	1	PHF15	5	133902013	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	38983317	133902013	47013247	36	10309											
EBF1	1879	broad.mit.edu	37	chr5	158523369	158523369	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	accattgctgtagagaagctGaagccggtagtgaattccgt	12	8	0	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr5:158523369G>T	uc010jip.2	-	3	639	c.337C>A	c.(337-339)CAG>AAG	p.Q113K	EBF1_uc011ddw.1_5'UTR|EBF1_uc011ddx.1_Missense_Mutation_p.Q113K|EBF1_uc003lxl.3_Missense_Mutation_p.Q113K	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	113					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TAGAGAAGCTGAAGCCGGTAG	0.592			T	HMGA2	lipoma								T	158523369	T	T	158523369	3	4	150	1	0	0	0	0	1	0	0	0	4880	1299	45	5	1494	5	EBF1	5	158523369	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	24621356	158523369	22391891	37	10310											
TDP2	51567	broad.mit.edu	37	chr6	24666809	24666809	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccaaggcgctctcctccaCcggaggctcgaagtaggagt	12	13	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr6:24666809C>T	uc003nej.2	-	2	221	c.196G>A	c.(196-198)GTG>ATG	p.V66M	TDP2_uc003nei.2_Translation_Start_Site|TDP2_uc010jpu.1_Missense_Mutation_p.V66M|ACOT13_uc010jpv.2_5'Flank|ACOT13_uc003nek.2_5'Flank	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	66					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2						CTCTCCTCCACCGGAGGCTCG	0.582								Direct_reversal_of_damage|Editing_and_processing_nucleases					T	24666809	T	T	24666809	3	4	150	1	0	0	0	0	1	0	0	0	15726	507	18	3	916	3	TDP2	6	24666809	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08		24666809	146448258	38	10311											
UHRF1BP1	54887	broad.mit.edu	37	chr6	34839664	34839664	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacagcccccaaaagaacagGtgtttttggtgcccacagga	11	11	0	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr6:34839664G>A	uc003oju.3	+	20	4393	c.4159G>A	c.(4159-4161)GTG>ATG	p.V1387M	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1387										ovary(3)	3						AAAAGAACAGGTGTTTTTGGT	0.468													A	34839664	A	A	34839664	3	1	150	1	0	0	0	0	1	0	0	0	16965	1261	44	3	4237	3	UHRF1BP1	6	34839664	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	10172855	34839664	136275403	39	10312											
TREML4	285852	broad.mit.edu	37	chr6	41196175	41196175	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgggctggaatggcctggGgtggggtccacacctgctgc	17	11	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr6:41196175G>A	uc003oqc.2	+	1	114	c.10G>A	c.(10-12)GGT>AGT	p.G4S	TREML4_uc003oqd.2_5'Flank	NM_198153	NP_937796	Q6UXN2	TRML4_HUMAN	triggering receptor expressed on myeloid	4						extracellular region				breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					AATGGCCTGGGGTGGGGTCCA	0.597													A	41196175	A	A	41196175	3	1	150	1	0	0	0	0	1	0	0	0	16471	1232	43	3	12	3	TREML4	6	41196175	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	6356511	41196175	129918892	40	10313											
FAM83B	222584	broad.mit.edu	37	chr6	54804576	54804576	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggacaacttgttgagtccttTgatgaagaatttagaactct	9	6	1	5			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr6:54804576T>G	uc003pck.2	+	5	923	c.807T>G	c.(805-807)TTT>TTG	p.F269L		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	269										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TTGAGTCCTTTGATGAAGAAT	0.398													G	54804576	G	G	54804576	3	3	150	1	0	0	0	0	1	0	0	0	5634	1809	63	5	821	5	FAM83B	6	54804576	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	13608401	54804576	116310491	41	10314											
ADAP1	11033	broad.mit.edu	37	chr7	959664	959664	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgtcgctcgtacttggccCggatccactgctctcgaagg	11	15	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:959664C>T	uc003sjo.3	-	4	505	c.329G>A	c.(328-330)CGG>CAG	p.R110Q	ADAP1_uc011jvs.1_Missense_Mutation_p.R15Q|ADAP1_uc003sjn.3_Missense_Mutation_p.R38Q|ADAP1_uc010ksc.2_Missense_Mutation_p.R38Q	NM_006869	NP_006860	O75689	ADAP1_HUMAN	centaurin, alpha 1	110	Arf-GAP.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding	p.R110Q(1)		upper_aerodigestive_tract(1)	1						GTACTTGGCCCGGATCCACTG	0.682													T	959664	T	T	959664	3	4	150	1	0	0	0	0	1	0	0	0	279	652	23	2	827	2	ADAP1	7	959664	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08		959664	158178999	42	10315											
MAD1L1	8379	broad.mit.edu	37	chr7	2255803	2255803	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acccctcaccgcaggtgcgcGctctcctcccgcagctgctt	9	20	2	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:2255803G>A	uc003slh.1	-	8	1064	c.798C>T	c.(796-798)AGC>AGT	p.S266S	MAD1L1_uc003sle.1_5'Flank|MAD1L1_uc003slf.1_Silent_p.S266S|MAD1L1_uc003slg.1_Silent_p.S266S|MAD1L1_uc010ksh.1_Silent_p.S266S|MAD1L1_uc003sli.1_Silent_p.S174S|MAD1L1_uc010ksi.1_Silent_p.S219S|MAD1L1_uc010ksj.2_Silent_p.S266S	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	266	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GCAGGTGCGCGCTCTCCTCCC	0.637													A	2255803	A	A	2255803	2	1	150	1	0	0	0	0	0	0	0	1	9147	1078	38	1		1	MAD1L1	7	2255803	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	1296139	2255803	156882860	43	10316											
ELMO1	9844	broad.mit.edu	37	chr7	36917679	36917679	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttctaagtctccgtaatgCaggactttgtgatttggcga	10	8	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:36917679C>T	uc003tfk.1	-	19	2065	c.1758G>A	c.(1756-1758)CTG>CTA	p.L586L	ELMO1_uc003tfi.1_Silent_p.L106L|ELMO1_uc003tfj.1_Silent_p.L106L|ELMO1_uc011kbb.1_RNA|ELMO1_uc011kbc.1_Silent_p.L490L|ELMO1_uc010kxg.1_Silent_p.L586L	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	586	PH.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						CTCCGTAATGCAGGACTTTGT	0.453													T	36917679	T	T	36917679	2	4	150	1	0	0	0	0	0	0	0	1	5065	697	25	3		3	ELMO1	7	36917679	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	34661876	36917679	122220984	44	10317											
ELMO1	9844	broad.mit.edu	37	chr7	37172811	37172811	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatcccaggtggagtctgcGtgaagtccatggcagggttg	15	9	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:37172811G>A	uc003tfk.1	-	14	1422	c.1115C>T	c.(1114-1116)ACG>ATG	p.T372M	ELMO1_uc011kbc.1_Missense_Mutation_p.T276M|ELMO1_uc010kxg.1_Missense_Mutation_p.T372M	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	372	ELMO.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						TGGAGTCTGCGTGAAGTCCAT	0.463													A	37172811	A	A	37172811	3	1	150	1	0	0	0	0	1	0	0	0	5065	1145	40	1	1104	1	ELMO1	7	37172811	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	255132	37172811	121965852	45	10318											
DDC	1644	broad.mit.edu	37	chr7	50596925	50596925	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctgatcggatgagtaagccAccagcttctccatgatagcg	10	12	1	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:50596925A>G	uc003tpf.3	-	5	637	c.551T>C	c.(550-552)GTG>GCG	p.V184A	DDC_uc010kza.2_Intron|DDC_uc003tpg.3_Missense_Mutation_p.V184A	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	184					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding	p.V184V(1)		ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TGAGTAAGCCACCAGCTTCTC	0.547													G	50596925	G	G	50596925	3	3	150	1	0	0	0	0	1	0	0	0	4325	159	6	4	931	4	DDC	7	50596925	Missense_Mutation	SNP	A	TCGA-16-1045-01B-01W-0611-08	13424114	50596925	108541738	46	10319											
EGFR	1956	broad.mit.edu	37	chr7	55221743	55221743	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgaagccacgtgcaaggacAcctgccccccactcatgctc	8	18	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:55221743A>C	uc003tqk.2	+	7	1033	c.787A>C	c.(787-789)ACC>CCC	p.T263P	EGFR_uc003tqh.2_Missense_Mutation_p.T263P|EGFR_uc003tqi.2_Missense_Mutation_p.T263P|EGFR_uc003tqj.2_Missense_Mutation_p.T263P|EGFR_uc010kzg.1_Missense_Mutation_p.T218P|EGFR_uc011kco.1_Missense_Mutation_p.T210P|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	263	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.T263P(4)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGCAAGGACACCTGCCCCCC	0.577		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			C	55221743	C	C	55221743	3	2	150	1	0	0	0	0	1	0	0	0	4967	159	6	5	813	5	EGFR	7	55221743	Missense_Mutation	SNP	A	TCGA-16-1045-01B-01W-0611-08	4624818	55221743	103916920	47	10320											
CACNA2D1	781	broad.mit.edu	37	chr7	81589046	81589046	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaaggatacaagtctgctcCgcttgtatgagcagtcgtgt	11	9	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:81589046C>T	uc003uhr.1	-	37	3322	c.3066G>A	c.(3064-3066)GCG>GCA	p.A1022A	CACNA2D1_uc011kgy.1_Silent_p.A234A	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	1034	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AAGTCTGCTCCGCTTGTATGA	0.368													T	81589046	T	T	81589046	2	4	150	1	0	0	0	0	0	0	0	1	2548	639	23	2		2	CACNA2D1	7	81589046	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	26367303	81589046	77549617	48	10321											
ABCB1	5243	broad.mit.edu	37	chr7	87214993	87214993	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtcaagccaatttgaatagcGaaactaaaaagagagaaaaa	8	5	1	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:87214993G>A	uc003uiz.1	-	5	539	c.121C>T	c.(121-123)CGC>TGC	p.R41C	ABCB1_uc011khc.1_Missense_Mutation_p.R41C	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	41	Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTTGAATAGCGAAACTAAAAA	0.328													A	87214993	A	A	87214993	3	1	150	1	0	0	0	0	1	0	0	0	40	1058	37	2	3821	2	ABCB1	7	87214993	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	5625947	87214993	71923670	49	10322											
RUNDC3B	154661	broad.mit.edu	37	chr7	87280179	87280179	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgatcggtcttgctttgagaCaattgatgattcttctcctg	9	8	3	4			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:87280179C>A	uc003ujb.2	+	2	575	c.164C>A	c.(163-165)ACA>AAA	p.T55K	ABCB1_uc003uiz.1_Intron|ABCB1_uc003uja.1_Intron|ABCB1_uc010lei.1_Intron|RUNDC3B_uc011khd.1_Missense_Mutation_p.T55K|RUNDC3B_uc011khe.1_Missense_Mutation_p.T55K|RUNDC3B_uc003ujc.2_Missense_Mutation_p.T55K	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	55										skin(1)	1	Esophageal squamous(14;0.00164)					TGCTTTGAGACAATTGATGAT	0.338													A	87280179	A	A	87280179	3	1	150	1	0	0	0	0	1	0	0	0	13745	478	17	5	170	5	RUNDC3B	7	87280179	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	65186	87280179	71858484	50	10323											
PON1	5444	broad.mit.edu	37	chr7	94937424	94937424	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acaacatacgaccacgctaaAcccaaatacatctcccagga	4	15	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:94937424A>T	uc003uns.2	-	6	694	c.597T>A	c.(595-597)GGT>GGA	p.G199G	PON1_uc011kih.1_Silent_p.G199G	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	199					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	ACCACGCTAAACCCAAATACA	0.418													T	94937424	T	T	94937424	2	4	150	1	0	0	0	0	0	0	0	1	12248	30	2	5		5	PON1	7	94937424	Silent	SNP	A	TCGA-16-1045-01B-01W-0611-08	7657245	94937424	64201239	51	10324											
LRCH4	4034	broad.mit.edu	37	chr7	100175848	100175848	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgagtccagcccaccatcGtaccgatgtcccggaaatag	9	15	0	1	rs150987161	byFrequency	TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:100175848G>A	uc003uvj.2	-	7	935	c.882C>T	c.(880-882)TAC>TAT	p.Y294Y	LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjw.1_Translation_Start_Site|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	294					nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCCACCATCGTACCGATGTC	0.597													A	100175848	A	A	100175848	2	1	150	1	0	0	0	0	0	0	0	1	8935	1140	40	1		1	LRCH4	7	100175848	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	5238424	100175848	58962815	52	10325											
PCOLCE	5118	broad.mit.edu	37	chr7	100201641	100201641	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgacctggagctgcacccCgcctgccgctacgatgctct	10	17	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr7:100201641C>T	uc003uvo.2	+	3	462	c.264C>T	c.(262-264)CCC>CCT	p.P88P	uc011kjy.1_RNA|PCOLCE_uc011kkb.1_Silent_p.P88P|PCOLCE_uc010lhb.1_Intron|PCOLCE_uc003uvp.1_5'Flank	NM_002593	NP_002584	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	88	CUB 1.				multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity				0	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					AGCTGCACCCCGCCTGCCGCT	0.672													T	100201641	T	T	100201641	2	4	150	1	0	0	0	0	0	0	0	1	11594	639	23	2		2	PCOLCE	7	100201641	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	25793	100201641	58937022	53	10326											
SH2D4A	63898	broad.mit.edu	37	chr8	19190497	19190497	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcggttcattggaaacttggAgctgataaggaagtctgggt	14	5	2	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr8:19190497A>G	uc003wzb.2	+	3	549	c.213A>G	c.(211-213)GGA>GGG	p.G71G	SH2D4A_uc011kym.1_Silent_p.G26G|SH2D4A_uc003wzc.2_Silent_p.G71G	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	71						cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)		GGAAACTTGGAGCTGATAAGG	0.408													G	19190497	G	G	19190497	2	3	150	1	0	0	0	0	0	0	0	1	14235	291	11	4		4	SH2D4A	8	19190497	Silent	SNP	A	TCGA-16-1045-01B-01W-0611-08		19190497	127173525	54	10327											
CPSF1	29894	broad.mit.edu	37	chr8	145623823	145623823	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccatgatctcctgccccGtctgcaggatctgcgggcga	12	15	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr8:145623823G>A	uc003zcj.2	-	19	1838	c.1763C>T	c.(1762-1764)ACG>ATG	p.T588M		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	588					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CTCCTGCCCCGTCTGCAGGAT	0.672													A	145623823	A	A	145623823	3	1	150	1	0	0	0	0	1	0	0	0	3824	1145	40	1	2648	1	CPSF1	8	145623823	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	126433326	145623823	740199	55	10328											
LRRC14	9684	broad.mit.edu	37	chr8	145745327	145745327	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagtgtgcccactgcagccGtgccctcctgcaggagcggc	15	15	0	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr8:145745327G>A	uc003zdk.1	+	2	364	c.218G>A	c.(217-219)CGT>CAT	p.R73H	RECQL4_uc003zdj.2_5'Flank|LRRC14_uc003zdl.1_Missense_Mutation_p.R73H|LRRC14_uc003zdo.2_5'Flank	NM_014665	NP_055480	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	73											0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CACTGCAGCCGTGCCCTCCTG	0.627													A	145745327	A	A	145745327	3	1	150	1	0	0	0	0	1	0	0	0	8968	1145	40	1	220	1	LRRC14	8	145745327	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	121504	145745327	618695	56	10329											
VLDLR	7436	broad.mit.edu	37	chr9	2643641	2643641	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgtagcctctcgaacttgCcgacctgaccaatttgaatg	8	11	1	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr9:2643641C>T	uc003zhk.1	+	6	1231	c.834C>T	c.(832-834)TGC>TGT	p.C278C	VLDLR_uc003zhl.1_Silent_p.C278C|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Silent_p.C237C	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	278	Extracellular (Potential).|LDL-receptor class A 7.				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		CTCGAACTTGCCGACCTGACC	0.488													T	2643641	T	T	2643641	2	4	150	1	0	0	0	0	0	0	0	1	17171	747	26	3		3	VLDLR	9	2643641	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08		2643641	138569790	57	10330											
FAM122A	116224	broad.mit.edu	37	chr9	71395730	71395730	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaatatcagccaaagagatTtttccagggcatcaccaaca	7	10	2	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr9:71395730T>C	uc004agw.1	+	1	767	c.650T>C	c.(649-651)TTT>TCT	p.F217S	PIP5K1B_uc004agu.2_Intron|PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_Intron	NM_138333	NP_612206	Q96E09	F122A_HUMAN	hypothetical protein LOC116224	217											0						CCAAAGAGATTTTTCCAGGGC	0.453													C	71395730	C	C	71395730	3	2	150	1	0	0	0	0	1	0	0	0	5419	1841	64	4	652	4	FAM122A	9	71395730	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	68752089	71395730	69817701	58	10331											
NFIL3	4783	broad.mit.edu	37	chr9	94172272	94172272	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtacccagagaaagaattccCcatatagttttgatagatgg	9	7	0	4			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr9:94172272C>T	uc004arh.2	-	2	1140	c.745G>A	c.(745-747)GGG>AGG	p.G249R		NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	249					circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						AAAGAATTCCCCATATAGTTT	0.498													T	94172272	T	T	94172272	3	4	150	1	0	0	0	0	1	0	0	0	10373	623	22	3	647	3	NFIL3	9	94172272	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	22776542	94172272	47041159	59	10332											
FGD3	89846	broad.mit.edu	37	chr9	95768391	95768391	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtatgtcaagaactttgacCgagccgtagggctggtgagc	14	8	1	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr9:95768391C>T	uc004asw.2	+	6	1394	c.766C>T	c.(766-768)CGA>TGA	p.R256*	FGD3_uc004asx.2_Nonsense_Mutation_p.R256*|FGD3_uc004asz.2_Nonsense_Mutation_p.R256*|FGD3_uc004ata.2_Nonsense_Mutation_p.R59*	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	256	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						GAACTTTGACCGAGCCGTAGG	0.582													T	95768391	T	T	95768391	4	4	150	1	0	0	0	0	0	1	0	0	5834	644	23	2	780	2	FGD3	9	95768391	Nonsense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	1596119	95768391	45445040	60	10333											
HEMGN	55363	broad.mit.edu	37	chr9	100700360	100700360	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctggagaatggttctcttctTgatgagggtcaggtgtctga	14	6	4	4			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr9:100700360T>C	uc004axy.2	-	1	167	c.59A>G	c.(58-60)CAA>CGA	p.Q20R	HEMGN_uc004axz.2_Missense_Mutation_p.Q20R	NM_197978	NP_932095	Q9BXL5	HEMGN_HUMAN	hemogen	20	Necessary for nuclear localization.				cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GTTCTCTTCTTGATGAGGGTC	0.423													C	100700360	C	C	100700360	3	2	150	1	0	0	0	0	1	0	0	0	7050	1812	63	4	1411	4	HEMGN	9	100700360	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	4931969	100700360	40513071	61	10334											
KLF4	9314	broad.mit.edu	37	chr9	110249362	110249362	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactctttgtgtaggttttgCcgcagcccgcgtaatcacaa	9	11	2	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr9:110249362C>T	uc004bdh.2	-	3	1907	c.1286G>A	c.(1285-1287)GGC>GAC	p.G429D	KLF4_uc004bdf.1_Missense_Mutation_p.G354D|KLF4_uc004bdg.2_Missense_Mutation_p.G404D	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	438	C2H2-type 1.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						GTAGGTTTTGCCGCAGCCCGC	0.602													T	110249362	T	T	110249362	3	4	150	1	0	0	0	0	1	0	0	0	8348	739	26	3	236	3	KLF4	9	110249362	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	9549002	110249362	30964069	62	10335											
PTEN	5728	broad.mit.edu	37	chr10	89720852	89720852	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaataaagacaaagccaacCgatacttttctccaaatttt	3	10	1	1	rs121909231		TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr10:89720852C>T	uc001kfb.2	+	9	2034	c.1003C>T	c.(1003-1005)CGA>TGA	p.R335*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	335	C2 tensin-type.			KANKDKANR->AAGADAANA: Reduces growth suppression activity and promotes anchorage-independent growth. Reduces binding to phospholipid membranes in vitro; phosphatase activity towards PtdIns(3,4,5)P3 is not affected.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R335*(21)|p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.R335fs*8(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.R335fs*4(1)|p.R335fs*7(1)|p.W274_F341del(1)|p.R335R(1)|p.D326_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CAAAGCCAACCGATACTTTTC	0.333		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89720852	T	T	89720852	4	4	150	1	0	0	0	0	0	1	0	0	12738	644	23	2	1033	2	PTEN	10	89720852	Nonsense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08		89720852	45813895	63	10336											
COL17A1	1308	broad.mit.edu	37	chr10	105813706	105813706	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctttttgaccctttggtccTtgtggacctgggtggcccaa	11	12	0	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr10:105813706T>C	uc001kxr.2	-	22	1975	c.1806A>G	c.(1804-1806)CAA>CAG	p.Q602Q	COL17A1_uc010qqv.1_Silent_p.Q586Q	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	602	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CCTTTGGTCCTTGTGGACCTG	0.408													C	105813706	C	C	105813706	2	2	150	1	0	0	0	0	0	0	0	1	3674	1606	56	4		4	COL17A1	10	105813706	Silent	SNP	T	TCGA-16-1045-01B-01W-0611-08	16092854	105813706	29721041	64	10337											
WDR11	55717	broad.mit.edu	37	chr10	122645345	122645345	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggagtggtcaccatctcacaActtgaagagcctgagaaaga	11	9	2	4			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr10:122645345A>G	uc010qtf.1	+	15	2106	c.1868A>G	c.(1867-1869)AAC>AGC	p.N623S	WDR11_uc010qte.1_Missense_Mutation_p.N225S|WDR11_uc001lfd.1_Missense_Mutation_p.N141S|WDR11_uc009xzn.2_5'Flank	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	623						integral to membrane					0						CCATCTCACAACTTGAAGAGC	0.488													G	122645345	G	G	122645345	3	3	150	1	0	0	0	0	1	0	0	0	17270	43	2	4	1926	4	WDR11	10	122645345	Missense_Mutation	SNP	A	TCGA-16-1045-01B-01W-0611-08	16831639	122645345	12889402	65	10338											
OR51A2	401667	broad.mit.edu	37	chr11	4976146	4976146	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgaggggagagacatgcccGgcaaagcggtggacaacggc	17	9	0	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr11:4976146G>A	uc010qyt.1	-	1	798	c.798C>T	c.(796-798)GCC>GCT	p.A266A		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGACATGCCCGGCAAAGCGGT	0.453													A	4976146	A	A	4976146	2	1	150	1	0	0	0	0	0	0	0	1	11086	1103	39	2		2	OR51A2	11	4976146	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08		4976146	130030370	66	10339											
TRIM5	85363	broad.mit.edu	37	chr11	5699638	5699638	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctcaaaatctgccaagacGttggttttgtcatactgtat	8	8	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr11:5699638G>A	uc001mbm.1	-	4	797	c.540C>T	c.(538-540)AAC>AAT	p.N180N	TRIM5_uc001mbq.1_Silent_p.N180N|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Silent_p.N180N|TRIM5_uc001mbo.2_Silent_p.N180N|TRIM5_uc001mbp.2_Silent_p.N180N	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	180	Potential.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		CTGCCAAGACGTTGGTTTTGT	0.473													A	5699638	A	A	5699638	2	1	150	1	0	0	0	0	0	0	0	1	16522	1136	40	1		1	TRIM5	11	5699638	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	723492	5699638	129306878	67	10340											
NAV2	89797	broad.mit.edu	37	chr11	20065530	20065530	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	agagtctctgtccacagactGatgctgagaagcactcacag	10	11	2	4			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr11:20065530G>A	uc010rdm.1	+	14	3341	c.2980G>A	c.(2980-2982)GAT>AAT	p.D994N	NAV2_uc001mpp.2_Missense_Mutation_p.D907N|NAV2_uc001mpr.3_Missense_Mutation_p.D971N|NAV2_uc001mpt.2_Missense_Mutation_p.D57N|NAV2_uc009yhx.2_Missense_Mutation_p.D57N|NAV2_uc009yhy.1_5'UTR	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	994						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TCCACAGACTGATGCTGAGAA	0.507													A	20065530	A	A	20065530	3	1	150	1	0	0	0	0	1	0	0	0	10184	1290	45	3	3070	3	NAV2	11	20065530	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	14365892	20065530	114940986	68	10341											
OR10AG1	282770	broad.mit.edu	37	chr11	55735214	55735214	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gtgatagtacctgctccaaaGaataagattacaactattag	7	7	0	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr11:55735214G>T	uc010rit.1	-	1	726	c.726C>A	c.(724-726)TTC>TTA	p.F242L		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					CTGCTCCAAAGAATAAGATTA	0.388													T	55735214	T	T	55735214	3	4	150	1	0	0	0	0	1	0	0	0	10897	933	33	5	182	5	OR10AG1	11	55735214	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	35669684	55735214	79271302	69	10342											
OR5B2	390190	broad.mit.edu	37	chr11	58189829	58189829	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agaaatttttgccttctcaaCactttcttgaatgcattctg	5	9	3	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr11:58189829C>A	uc010rkg.1	-	1	906	c.906G>T	c.(904-906)GTG>GTT	p.V302V		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GCCTTCTCAACACTTTCTTGA	0.383													A	58189829	A	A	58189829	2	1	150	1	0	0	0	0	0	0	0	1	11150	465	17	5		5	OR5B2	11	58189829	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	2454615	58189829	76816687	70	10343											
WDR74	54663	broad.mit.edu	37	chr11	62602979	62602979	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggtcccagatgggaaccCgcaagtccagccagtcattc	10	15	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr11:62602979C>T	uc001nvm.1	-	7	710	c.542G>A	c.(541-543)CGG>CAG	p.R181Q	WDR74_uc001nvk.1_Missense_Mutation_p.R124Q|WDR74_uc001nvl.1_Missense_Mutation_p.R181Q|WDR74_uc001nvn.1_Missense_Mutation_p.R233Q|WDR74_uc009yoi.1_Missense_Mutation_p.R181Q|WDR74_uc010rmk.1_3'UTR	NM_018093	NP_060563	Q6RFH5	WDR74_HUMAN	WD repeat domain 74	181	WD 4.					nucleolus				ovary(1)	1						GATGGGAACCCGCAAGTCCAG	0.607													T	62602979	T	T	62602979	3	4	150	1	0	0	0	0	1	0	0	0	17321	652	23	2	639	2	WDR74	11	62602979	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	4413150	62602979	72403537	71	10344											
HTR3B	9177	broad.mit.edu	37	chr11	113813844	113813844	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttcaagaccagtgtgctggtGggctacaccgtcttcagggt	13	10	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr11:113813844G>T	uc001pok.2	+	7	904	c.837G>T	c.(835-837)GTG>GTT	p.V279V	HTR3B_uc001pol.2_Silent_p.V268V	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	279	Helical; Name=2; (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GTGTGCTGGTGGGCTACACCG	0.572													T	113813844	T	T	113813844	2	4	150	1	0	0	0	0	0	0	0	1	7445	1335	47	5		5	HTR3B	11	113813844	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	51210865	113813844	21192672	72	10345											
VWF	7450	broad.mit.edu	37	chr12	6058287	6058287	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccacctgcatgggctccGtccgtgtcggagagcagcag	16	13	0	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:6058287G>A	uc001qnn.1	-	52	8586	c.8336C>T	c.(8335-8337)ACG>ATG	p.T2779M	ANO2_uc001qnm.2_5'Flank|VWF_uc010set.1_3'UTR	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2779	CTCK.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CATGGGCTCCGTCCGTGTCGG	0.562													A	6058287	A	A	6058287	3	1	150	1	0	0	0	0	1	0	0	0	17243	1145	40	1	109	1	VWF	12	6058287	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08		6058287	127793608	73	10346											
GYS2	2998	broad.mit.edu	37	chr12	21733300	21733300	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccatgcttattcattgcGtccactgctcttctgacagc	7	14	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:21733300G>A	uc001rfb.2	-	2	534	c.279C>T	c.(277-279)GAC>GAT	p.D93D		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	93					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						TATTCATTGCGTCCACTGCTC	0.403													A	21733300	A	A	21733300	2	1	150	1	0	0	0	0	0	0	0	1	6913	1136	40	1		1	GYS2	12	21733300	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	15675013	21733300	112118595	74	10347											
MBD6	114785	broad.mit.edu	37	chr12	57922312	57922312	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgagcccaaggatccacCccctcccgggccccattctg	9	19	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:57922312C>T	uc001soj.1	+	10	3013	c.2789C>T	c.(2788-2790)CCC>CTC	p.P930L	MBD6_uc001sok.1_Missense_Mutation_p.P798L|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	930						chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						AAGGATCCACCCCCTCCCGGG	0.577													T	57922312	T	T	57922312	3	4	150	1	0	0	0	0	1	0	0	0	9348	623	22	3	2819	3	MBD6	12	57922312	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	36189012	57922312	75929583	75	10348											
ZFC3H1	196441	broad.mit.edu	37	chr12	72025622	72025622	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggacatggcttcacttccaTtgttttactttgtgctgtga	9	8	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:72025622T>C	uc001swo.2	-	16	3765	c.3406A>G	c.(3406-3408)ATG>GTG	p.M1136V		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1136					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TTCACTTCCATTGTTTTACTT	0.358													C	72025622	C	C	72025622	3	2	150	1	0	0	0	0	1	0	0	0	17630	1493	52	4	2643	4	ZFC3H1	12	72025622	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	14103310	72025622	61826273	76	10349											
SSH1	54434	broad.mit.edu	37	chr12	109212060	109212060	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttcgcaacgcagaaggttgaTcatcacctgaagatgttgag	11	8	2	5			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:109212060T>A	uc001tnm.2	-	4	331	c.244A>T	c.(244-246)ATC>TTC	p.I82F	SSH1_uc010sxg.1_Missense_Mutation_p.I93F|SSH1_uc001tnn.3_Missense_Mutation_p.I82F|SSH1_uc001tno.1_5'Flank	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	82					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						AGAAGGTTGATCATCACCTGA	0.338													A	109212060	A	A	109212060	3	1	150	1	0	0	0	0	1	0	0	0	15183	1435	50	5	3139	5	SSH1	12	109212060	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	37186438	109212060	24639835	77	10350											
ACACB	32	broad.mit.edu	37	chr12	109639415	109639415	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacgttcaggaaagaggccGggtgaagtacatcaagcgtc	14	8	2	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:109639415G>A	uc001tob.2	+	19	2941	c.2822G>A	c.(2821-2823)CGG>CAG	p.R941Q	ACACB_uc001toc.2_Missense_Mutation_p.R941Q	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	941	Biotinyl-binding.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GAAAGAGGCCGGGTGAAGTAC	0.542													A	109639415	A	A	109639415	3	1	150	1	0	0	0	0	1	0	0	0	107	1116	39	2	2892	2	ACACB	12	109639415	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	427355	109639415	24212480	78	10351											
CUX2	23316	broad.mit.edu	37	chr12	111772383	111772383	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agagggccgctccagctcctCgttgagcgggaagatgtact	14	11	0	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:111772383C>T	uc001tsa.1	+	19	3218	c.3065C>T	c.(3064-3066)TCG>TTG	p.S1022L		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1022						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TCCAGCTCCTCGTTGAGCGGG	0.647													T	111772383	T	T	111772383	3	4	150	1	0	0	0	0	1	0	0	0	4065	893	31	2	3139	2	CUX2	12	111772383	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	2132968	111772383	22079512	79	10352											
PITPNM2	57605	broad.mit.edu	37	chr12	123481392	123481393	+	Frame_Shift_Ins	INS	-	C	C													ggtggccagcagggggagggINScagccaggggaatgtggtcc							TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:123481392_123481393insC	uc001uej.1	-	11	1676_1677	c.1537_1538insG	c.(1537-1539)GCCfs	p.A513fs	PITPNM2_uc001uek.1_Frame_Shift_Ins_p.A513fs	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	513					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CAGGGGGAGGGCAGCCAGGGGA	0.639													C	123481393	C	C	123481392	7	5	150	1	0	1	1	0	0	0	0	0	11951	1203	42	0	2571	0	PITPNM2	12	123481392	Frame_Shift_Ins	INS	-	TCGA-16-1045-01B-01W-0611-08	11709009	123481392	10370503	80	10353											
DNAH10	196385	broad.mit.edu	37	chr12	124333280	124333280	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgtctttcttcctaggccGtggggaagattttctctggc	11	10	3	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:124333280G>A	uc001uft.3	+	33	5624	c.5599G>A	c.(5599-5601)GTG>ATG	p.V1867M		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1867	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTCCTAGGCCGTGGGGAAGAT	0.443													A	124333280	A	A	124333280	3	1	150	1	0	0	0	0	1	0	0	0	4598	1145	40	1	5729	1	DNAH10	12	124333280	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	851888	124333280	9518615	81	10354											
RIMBP2	23504	broad.mit.edu	37	chr12	130935764	130935764	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gactcagatctgcatcttgcGctaccggatctcgacaggaa	10	12	4	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:130935764G>A	uc001uil.2	-	5	593	c.429C>T	c.(427-429)AGC>AGT	p.S143S	RIMBP2_uc001uim.2_Silent_p.S51S	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	143						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGCATCTTGCGCTACCGGATC	0.637													A	130935764	A	A	130935764	2	1	150	1	0	0	0	0	0	0	0	1	13363	1078	38	1		1	RIMBP2	12	130935764	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	6602484	130935764	2916131	82	10355											
GPR133	283383	broad.mit.edu	37	chr12	131620612	131620612	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaggcagtggccgtgctgctGcccatcctgggtacctcgtg	14	13	0	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:131620612G>C	uc001uit.3	+	22	2857	c.2298G>C	c.(2296-2298)CTG>CTC	p.L766L	GPR133_uc010tbm.1_Silent_p.L798L|GPR133_uc009zyo.2_Silent_p.L48L|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	766	Helical; Name=6; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CCGTGCTGCTGCCCATCCTGG	0.592													C	131620612	C	C	131620612	2	2	150	1	0	0	0	0	0	0	0	1	6643	1306	46	5		5	GPR133	12	131620612	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	684848	131620612	2231283	83	10356											
ZNF140	7699	broad.mit.edu	37	chr12	133682985	133682985	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggcatgcatcccttattcaAcatacgaagagtcacactgg	8	11	2	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr12:133682985A>G	uc001ulo.2	+	5	1792	c.1122A>G	c.(1120-1122)CAA>CAG	p.Q374Q	ZNF140_uc001ulp.2_Silent_p.Q271Q|ZNF140_uc010tbu.1_Silent_p.Q271Q	NM_003440	NP_003431	P52738	ZN140_HUMAN	zinc finger protein 140	374	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.114)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CCCTTATTCAACATACGAAGA	0.408													G	133682985	G	G	133682985	2	3	150	1	0	0	0	0	0	0	0	1	17726	40	2	4		4	ZNF140	12	133682985	Silent	SNP	A	TCGA-16-1045-01B-01W-0611-08	2062373	133682985	168910	84	10357											
LBXCOR1	390598	broad.mit.edu	37	chr15	68118859	68118859	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactcgcaccgaacacccgaCgccaagtacacgcagcccga	8	19	0	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr15:68118859C>T	uc002aqy.1	+	2	666	c.666C>T	c.(664-666)GAC>GAT	p.D222D		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	231					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						GAACACCCGACGCCAAGTACA	0.572													T	68118859	T	T	68118859	2	4	150	1	0	0	0	0	0	0	0	1	8655	535	19	1		1	LBXCOR1	15	68118859	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08		68118859	34412533	85	10358											
C15orf32	145858	broad.mit.edu	37	chr15	93015653	93015653	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagatgccaaagctcacgagTggatggtttgatgctgaagc	13	7	1	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr15:93015653T>C	uc002brc.1	+	1	747	c.275T>C	c.(274-276)GTG>GCG	p.V92A	C15orf32_uc010bod.1_RNA	NM_153040	NP_694585	Q32M92	CO032_HUMAN	hypothetical protein LOC145858	92										ovary(1)	1	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			agctcacgagtggATGGTTTG	0.279													C	93015653	C	C	93015653	3	2	150	1	0	0	0	0	1	0	0	0	1790	1696	59	4	277	4	C15orf32	15	93015653	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	24896794	93015653	9515739	86	10359											
UNKL	64718	broad.mit.edu	37	chr16	1449391	1449391	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacctgtactggaaccgccGggggttgcgccgcctgtccc	13	16	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr16:1449391G>A	uc010bro.1	-	5	726	c.718C>T	c.(718-720)CGG>TGG	p.R240W	UNKL_uc002clq.2_Missense_Mutation_p.R240W	NM_001037125	NP_001032202	Q9H9P5	UNKL_HUMAN	unkempt homolog (Drosophila)-like isoform 2	240						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				TGGAACCGCCGGGGGTTGCGC	0.701													A	1449391	A	A	1449391	3	1	150	1	0	0	0	0	1	0	0	0	16998	1115	39	2	838	2	UNKL	16	1449391	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08		1449391	88905362	87	10360											
FBXO31	79791	broad.mit.edu	37	chr16	87368933	87368933	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatcttggtgcccctggcacGccggccgtggaagctgagca	15	13	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr16:87368933G>A	uc002fjw.2	-	7	1017	c.973C>T	c.(973-975)CGT>TGT	p.R325C	FBXO31_uc010vot.1_Missense_Mutation_p.R153C|FBXO31_uc002fjv.2_Missense_Mutation_p.R217C	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	325					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		CCCCTGGCACGCCGGCCGTGG	0.662													A	87368933	A	A	87368933	3	1	150	1	0	0	0	0	1	0	0	0	5741	1087	38	1	658	1	FBXO31	16	87368933	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	85919542	87368933	2985820	88	10361											
OR1G1	8390	broad.mit.edu	37	chr17	3029921	3029921	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccactaaggggaatgaatttTccgaacccagattaactttc	7	10	0	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr17:3029921T>C	uc002fvc.1	-	1	925	c.925A>G	c.(925-927)AAA>GAA	p.K309E		NM_003555	NP_003546	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAATGAATTTTCCGAACCCAG	0.428													C	3029921	C	C	3029921	3	2	150	1	0	0	0	0	1	0	0	0	10957	1792	62	4	20	4	OR1G1	17	3029921	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08		3029921	78165289	89	10362											
SLC6A4	6532	broad.mit.edu	37	chr17	28545202	28545202	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgttgtcctcggagaagtaaTtggtgcagttgccagtgttc	13	7	0	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr17:28545202T>G	uc002hey.3	-	5	1176	c.632A>C	c.(631-633)AAT>ACT	p.N211T		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	211	Extracellular (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	GGAGAAGTAATTGGTGCAGTT	0.542													G	28545202	G	G	28545202	3	3	150	1	0	0	0	0	1	0	0	0	14686	1493	52	5	1304	5	SLC6A4	17	28545202	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	25515281	28545202	52650008	90	10363											
ZNHIT3	9326	broad.mit.edu	37	chr17	34851065	34851065	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttttttcttgttaatttttAggggaatctgcaacattaag	7	4	2	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr17:34851065A>G	uc002hms.1	+	5	358	c.287_splice	c.e5-2	p.G96_splice	ZNHIT3_uc002hmt.1_Splice_Site|ZNHIT3_uc010cut.1_Intron	NM_004773	NP_004764	Q15649	ZNHI3_HUMAN	thyroid hormone receptor interactor 3						regulation of transcription, DNA-dependent	intracellular	metal ion binding|thyroid hormone receptor binding				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0188)		GTTAATTTTTAGGGGAATCTG	0.403													G	34851065	G	G	34851065	5	3	150	1	0	0	0	0	0	0	1	0	18205	434	15	4	303	4	ZNHIT3	17	34851065	Splice_Site	SNP	A	TCGA-16-1045-01B-01W-0611-08	6305863	34851065	46344145	91	10364											
TNS4	84951	broad.mit.edu	37	chr17	38652473	38652473	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggcctccacctgtggggCttgctggagtcggccagggg	17	11	0	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr17:38652473C>T	uc010cxb.2	-	2	369	c.205G>A	c.(205-207)GCC>ACC	p.A69T		NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	69					apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			ACCTGTGGGGCTTGCTGGAGT	0.652													T	38652473	T	T	38652473	3	4	150	1	0	0	0	0	1	0	0	0	16342	797	28	3	1990	3	TNS4	17	38652473	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	3801408	38652473	42542737	92	10365											
MRC2	9902	broad.mit.edu	37	chr17	60758249	60758249	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggcgcagcgcatctgcacGtggttccaggccgagctgac	14	14	1	1	rs150592174		TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr17:60758249G>A	uc002jad.2	+	17	2964	c.2562G>A	c.(2560-2562)ACG>ACA	p.T854T	MRC2_uc002jae.2_Translation_Start_Site|MRC2_uc002jaf.2_5'Flank	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	854	Extracellular (Potential).|C-type lectin 5.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GCATCTGCACGTGGTTCCAGG	0.637													A	60758249	A	A	60758249	2	1	150	1	0	0	0	0	0	0	0	1	9758	1132	40	1		1	MRC2	17	60758249	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	22105776	60758249	20436961	93	10366											
ZNF521	25925	broad.mit.edu	37	chr18	22806841	22806841	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	acggaggtatagcccaccgtGaccagggaagggctgttgct	15	10	0	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr18:22806841G>A	uc002kvk.2	-	4	1288	c.1041C>T	c.(1039-1041)GTC>GTT	p.V347V	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.V347V|ZNF521_uc002kvl.2_Silent_p.V127V	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	347					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGCCCACCGTGACCAGGGAAG	0.542			T	PAX5	ALL								A	22806841	A	A	22806841	2	1	150	1	0	0	0	0	0	0	0	1	17962	1277	45	3		3	ZNF521	18	22806841	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08		22806841	55270407	94	10367											
TMPRSS9	360200	broad.mit.edu	37	chr19	2421886	2421886	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccccctggcctgcgaggaggCccctggcgtgttttatctgg	14	14	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr19:2421886C>G	uc010xgx.1	+	13	2087	c.2087C>G	c.(2086-2088)GCC>GGC	p.A696G		NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	696	Extracellular (Potential).|Peptidase S1 2.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCGAGGAGGCCCCTGGCGTG	0.617													G	2421886	G	G	2421886	3	3	150	1	0	0	0	0	1	0	0	0	16250	739	26	5	2137	5	TMPRSS9	19	2421886	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08		2421886	56707097	95	10368											
HOOK2	29911	broad.mit.edu	37	chr19	12876795	12876795	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctgcaggtcctccacctgGgcccgcagctcggatagctg	12	15	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr19:12876795G>A	uc002muy.2	-	16	1716	c.1545C>T	c.(1543-1545)GCC>GCT	p.A515A	HOOK2_uc010xmq.1_5'UTR|HOOK2_uc002muz.2_Silent_p.A515A	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	515	Sufficient for interaction with microtubules.|Potential.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						CCTCCACCTGGGCCCGCAGCT	0.672											OREG0025273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	12876795	A	A	12876795	2	1	150	1	0	0	0	0	0	0	0	1	7283	1219	43	3		3	HOOK2	19	12876795	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	10454909	12876795	46252188	96	10369											
RYR1	6261	broad.mit.edu	37	chr19	38954119	38954119	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagctggcggagaacatccaCgagctctgggcgctaacccg	13	13	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr19:38954119C>T	uc002oit.2	+	21	2764	c.2634C>T	c.(2632-2634)CAC>CAT	p.H878H	RYR1_uc002oiu.2_Silent_p.H878H	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	878	1.|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGAACATCCACGAGCTCTGGG	0.662													T	38954119	T	T	38954119	2	4	150	1	0	0	0	0	0	0	0	1	13768	535	19	1		1	RYR1	19	38954119	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	26077324	38954119	20174864	97	10370											
SLC6A16	28968	broad.mit.edu	37	chr19	49812323	49812323	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcctatgcctgtgttagacaAaacttgaccccctgctagag	9	12	0	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr19:49812323A>T	uc002pmz.2	-	7	1273	c.1039T>A	c.(1039-1041)TTG>ATG	p.L347M	SLC6A16_uc002pna.2_Missense_Mutation_p.L347M|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	347	Helical; Name=6; (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		GTGTTAGACAAAACTTGACCC	0.478													T	49812323	T	T	49812323	3	4	150	1	0	0	0	0	1	0	0	0	14679	11	1	5	1195	5	SLC6A16	19	49812323	Missense_Mutation	SNP	A	TCGA-16-1045-01B-01W-0611-08	10858204	49812323	9316660	98	10371											
SIGLEC9	27180	broad.mit.edu	37	chr19	51630344	51630344	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccagagggccagtctctgcGcctggtctgtgcagttgatg	14	12	2	2	rs149764192		TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr19:51630344G>A	uc002pvu.2	+	4	873	c.806G>A	c.(805-807)CGC>CAC	p.R269H	SIGLEC9_uc010yct.1_Missense_Mutation_p.R269H	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	269	Extracellular (Potential).|Ig-like C2-type 2.			R -> H (in Ref. 2; AAF87223).	cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CAGTCTCTGCGCCTGGTCTGT	0.483													A	51630344	A	A	51630344	3	1	150	1	0	0	0	0	1	0	0	0	14315	1087	38	1	820	1	SIGLEC9	19	51630344	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	1818021	51630344	7498639	99	10372											
ZNF581	51545	broad.mit.edu	37	chr19	56155985	56155985	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcctctggcattttcctcCgttgagaccatggagggccc	11	14	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr19:56155985C>T	uc002qln.2	+	2	764	c.48C>T	c.(46-48)TCC>TCT	p.S16S	ZNF581_uc002qlq.2_Silent_p.S16S|CCDC106_uc002qlr.2_5'Flank	NM_016535	NP_057619	Q9P0T4	ZN581_HUMAN	zinc finger protein 581	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CATTTTCCTCCGTTGAGACCA	0.617													T	56155985	T	T	56155985	2	4	150	1	0	0	0	0	0	0	0	1	18010	639	23	2		2	ZNF581	19	56155985	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	4525641	56155985	2972998	100	10373											
C20orf194	25943	broad.mit.edu	37	chr20	3274853	3274853	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcacaggaagatgggtccGcatcacaggctcctggctaa	12	12	1	1	rs145634255	by1000genomes	TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr20:3274853G>A	uc002wii.2	-	25	2221	c.2170C>T	c.(2170-2172)CGG>TGG	p.R724W	C20orf194_uc002wij.3_Missense_Mutation_p.R463W|C20orf194_uc002wik.2_Missense_Mutation_p.R398W	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	724											0						AGATGGGTCCGCATCACAGGC	0.468													A	3274853	A	A	3274853	3	1	150	1	0	0	0	0	1	0	0	0	2099	1086	38	1	1415	1	C20orf194	20	3274853	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08		3274853	59750667	101	10374											
SEC23B	10483	broad.mit.edu	37	chr20	18534935	18534935	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	atgcccgagtatgaaaacttCaagcaccttctgcaggcacc	8	13	2	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr20:18534935C>A	uc002wqz.1	+	18	2492	c.2049C>A	c.(2047-2049)TTC>TTA	p.F683L	SEC23B_uc002wra.1_Missense_Mutation_p.F683L|SEC23B_uc002wrb.1_Missense_Mutation_p.F683L|SEC23B_uc010zsb.1_Missense_Mutation_p.F665L|SEC23B_uc002wrc.1_Missense_Mutation_p.F683L	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	683					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						ATGAAAACTTCAAGCACCTTC	0.493													A	18534935	A	A	18534935	3	1	150	1	0	0	0	0	1	0	0	0	13992	825	29	5	2115	5	SEC23B	20	18534935	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	15260082	18534935	44490585	102	10375											
BPI	671	broad.mit.edu	37	chr20	36932754	36932754	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccagaagggcctggactaCggtaactggatgcctccctt	11	13	0	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr20:36932754C>T	uc002xib.2	+	1	203	c.141C>T	c.(139-141)TAC>TAT	p.Y47Y		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	47					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				GCCTGGACTACGGTAACTGGA	0.458													T	36932754	T	T	36932754	2	4	150	1	0	0	0	0	0	0	0	1	1490	550	19	1		1	BPI	20	36932754	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	18397819	36932754	26092766	103	10376											
SLC9A8	23315	broad.mit.edu	37	chr20	48503378	48503378	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cggcaggaccttaagggcttCgtgtggctggacgccaagta	15	10	0	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr20:48503378C>T	uc002xuv.1	+	15	1791	c.1581C>T	c.(1579-1581)TTC>TTT	p.F527F	SLC9A8_uc010zym.1_Silent_p.F227F|SLC9A8_uc010gid.2_Silent_p.F151F	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	527						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TTAAGGGCTTCGTGTGGCTGG	0.627													T	48503378	T	T	48503378	2	4	150	1	0	0	0	0	0	0	0	1	14720	883	31	2		2	SLC9A8	20	48503378	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	11570624	48503378	14522142	104	10377											
BRWD1	54014	broad.mit.edu	37	chr21	40571510	40571510	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gaatttcaccagtctccaatGaattgttatcagaatcactt	5	9	4	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr21:40571510G>T	uc002yxk.1	-	40	4971	c.4832C>A	c.(4831-4833)TCA>TAA	p.S1611*	BRWD1_uc010goc.1_Nonsense_Mutation_p.S254*|BRWD1_uc002yxl.2_Nonsense_Mutation_p.S1611*	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1611					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AGTCTCCAATGAATTGTTATC	0.378											OREG0003861	type=REGULATORY REGION|Gene=BRWD1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	T	40571510	T	T	40571510	4	4	150	1	0	0	0	0	0	1	0	0	1525	1294	45	5	2381	5	BRWD1	21	40571510	Nonsense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08		40571510	7558385	105	10378											
CABIN1	23523	broad.mit.edu	37	chr22	24466765	24466765	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactaggactccttgctccgGctgaaggactatcggcagtg	12	11	0	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr22:24466765G>A	uc002zzi.1	+	17	2374	c.2247G>A	c.(2245-2247)CGG>CGA	p.R749R	CABIN1_uc002zzj.1_Silent_p.R699R|CABIN1_uc002zzl.1_Silent_p.R749R	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	749					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CCTTGCTCCGGCTGAAGGACT	0.562													A	24466765	A	A	24466765	2	1	150	1	0	0	0	0	0	0	0	1	2528	1190	42	3		3	CABIN1	22	24466765	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08		24466765	26837801	106	10379											
RANGAP1	5905	broad.mit.edu	37	chr22	41654011	41654011	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcattcaggttgatgacccGcagcagggggttgacagcga	15	9	2	3			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chr22:41654011G>A	uc003azs.2	-	6	2185	c.715C>T	c.(715-717)CGG>TGG	p.R239W	RANGAP1_uc003azt.2_Missense_Mutation_p.R239W|RANGAP1_uc003azu.2_Missense_Mutation_p.R239W|RANGAP1_uc011aoz.1_Missense_Mutation_p.R184W	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	239	LRR 4.				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						TTGATGACCCGCAGCAGGGGG	0.627													A	41654011	A	A	41654011	3	1	150	1	0	0	0	0	1	0	0	0	13033	1086	38	1	1088	1	RANGAP1	22	41654011	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	17187246	41654011	9650555	107	10380											
OFD1	8481	broad.mit.edu	37	chrX	13786260	13786260	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgagtaatcaagaaataaaaGacaaatctgctcacagtgaa	7	6	3	4			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:13786260G>C	uc004cvp.3	+	21	3204	c.2845G>C	c.(2845-2847)GAC>CAC	p.D949H	OFD1_uc004cvr.3_Missense_Mutation_p.D479H|OFD1_uc011mil.1_Missense_Mutation_p.D516H|OFD1_uc004cvq.3_Missense_Mutation_p.D772H|OFD1_uc010nen.2_Missense_Mutation_p.D947H|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.D908H|OFD1_uc004cvv.3_Missense_Mutation_p.D907H	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	949	Mediates the interaction with SDCCAG8.|Potential.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						AGAAATAAAAGACAAATCTGC	0.358													C	13786260	C	C	13786260	3	2	150	1	0	0	0	0	1	0	0	0	10838	942	33	5	2927	5	OFD1	23	13786260	Missense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08		13786260	141484300	108	10381											
HUWE1	10075	broad.mit.edu	37	chrX	53612010	53612010	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggaccgtgtatcttcttcGgcctgcagtgaatcgcacgc	11	12	2	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:53612010G>A	uc004dsp.2	-	40	5365	c.4963C>T	c.(4963-4965)CGA>TGA	p.R1655*	HUWE1_uc004dsn.2_Nonsense_Mutation_p.R480*	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1655	WWE.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TATCTTCTTCGGCCTGCAGTG	0.378													A	53612010	A	A	53612010	4	1	150	1	0	0	0	0	0	1	0	0	7461	1124	39	2	8341	2	HUWE1	23	53612010	Nonsense_Mutation	SNP	G	TCGA-16-1045-01B-01W-0611-08	39825750	53612010	101658550	109	10382											
OGT	8473	broad.mit.edu	37	chrX	70777507	70777507	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attgctgagaggcacggcaaCctgtgcttagataaggtgtg	14	7	0	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:70777507C>A	uc004eaa.1	+	12	1804	c.1587C>A	c.(1585-1587)AAC>AAA	p.N529K	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.N519K|OGT_uc004eac.2_Missense_Mutation_p.N390K|OGT_uc004ead.2_Missense_Mutation_p.N148K	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	529					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					GGCACGGCAACCTGTGCTTAG	0.284													A	70777507	A	A	70777507	3	1	150	1	0	0	0	0	1	0	0	0	10847	506	18	5	1633	5	OGT	23	70777507	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	17165497	70777507	84493053	110	10383											
DRP2	1821	broad.mit.edu	37	chrX	100511129	100511129	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgaggaccagtacctgctgCggcactccagccccatcaca	9	17	1	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:100511129C>T	uc004egz.2	+	21	2638	c.2269C>T	c.(2269-2271)CGG>TGG	p.R757W	DRP2_uc011mrh.1_Missense_Mutation_p.R679W	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	757					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						GTACCTGCTGCGGCACTCCAG	0.582													T	100511129	T	T	100511129	3	4	150	1	0	0	0	0	1	0	0	0	4764	759	27	1	2343	1	DRP2	23	100511129	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	29733622	100511129	54759431	111	10384											
COL4A5	1287	broad.mit.edu	37	chrX	107939578	107939578	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacttgaggacacgaattagCcgatgtcaagtgtgcatgaa	12	7	1	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:107939578C>T	uc004enz.1	+	52	5248	c.5046C>T	c.(5044-5046)AGC>AGT	p.S1682S	COL4A5_uc011mso.1_Silent_p.S1679S|COL4A5_uc011msp.1_Silent_p.S358S	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1676	Collagen IV NC1.		Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CACGAATTAGCCGATGTCAAG	0.348									Alport_syndrome_with_Diffuse_Leiomyomatosis				T	107939578	T	T	107939578	2	4	150	1	0	0	0	0	0	0	0	1	3694	738	26	3		3	COL4A5	23	107939578	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	7428449	107939578	47330982	112	10385											
LONRF3	79836	broad.mit.edu	37	chrX	118145848	118145848	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttccttgtcccctgcacatcTttgagccttgttaccgcctg	7	15	1	1			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:118145848T>A	uc004eqw.2	+	8	1754	c.1723T>A	c.(1723-1725)TTT>ATT	p.F575I	LONRF3_uc004eqx.2_Missense_Mutation_p.F534I|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_Missense_Mutation_p.F319I	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	575	Lon.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						CCTGCACATCTTTGAGCCTTG	0.478													A	118145848	A	A	118145848	3	1	150	1	0	0	0	0	1	0	0	0	8896	1609	56	5	1753	5	LONRF3	23	118145848	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	10206270	118145848	37124712	113	10386											
FAM70A	55026	broad.mit.edu	37	chrX	119410766	119410766	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttaaagcctccaaggacagCggcagtgatgatgcccagga	12	11	0	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:119410766C>T	uc004eso.3	-	8	948	c.721G>A	c.(721-723)GCT>ACT	p.A241T	FAM70A_uc004esp.3_Missense_Mutation_p.A217T|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	241	Helical; (Potential).					integral to membrane				lung(1)|breast(1)	2						CCAAGGACAGCGGCAGTGATG	0.527													T	119410766	T	T	119410766	3	4	150	1	0	0	0	0	1	0	0	0	5605	768	27	1	340	1	FAM70A	23	119410766	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	1264918	119410766	35859794	114	10387											
GLUD2	2747	broad.mit.edu	37	chrX	120181970	120181970	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcacagccagcaccgcacGccctgcaagggaggtatccg	12	16	0	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:120181970G>A	uc004eto.2	+	1	509	c.432G>A	c.(430-432)ACG>ACA	p.T144T		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	144					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	AGCACCGCACGCCCTGCAAGG	0.572													A	120181970	A	A	120181970	2	1	150	1	0	0	0	0	0	0	0	1	6477	1074	38	1		1	GLUD2	23	120181970	Silent	SNP	G	TCGA-16-1045-01B-01W-0611-08	771204	120181970	35088590	115	10388											
OCRL	4952	broad.mit.edu	37	chrX	128701326	128701326	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagtatgactctaaaacagaCcggtgggattccaggtaaag	11	7	1	2			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:128701326C>A	uc004euq.2	+	14	1617	c.1452C>A	c.(1450-1452)GAC>GAA	p.D484E	OCRL_uc004eur.2_Missense_Mutation_p.D484E	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	484					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						CTAAAACAGACCGGTGGGATT	0.393													A	128701326	A	A	128701326	3	1	150	1	0	0	0	0	1	0	0	0	10823	506	18	5	1506	5	OCRL	23	128701326	Missense_Mutation	SNP	C	TCGA-16-1045-01B-01W-0611-08	8519356	128701326	26569234	116	10389											
XPNPEP2	7512	broad.mit.edu	37	chrX	128887224	128887224	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccctcctcaaggccagccaCgtaagtccacgttcaggcag	10	16	2	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:128887224C>T	uc004eut.1	+	11	1351	c.1107C>T	c.(1105-1107)CAC>CAT	p.H369H		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	369					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						AGGCCAGCCACGTAAGTCCAC	0.537													T	128887224	T	T	128887224	2	4	150	1	0	0	0	0	0	0	0	1	17440	550	19	1		1	XPNPEP2	23	128887224	Silent	SNP	C	TCGA-16-1045-01B-01W-0611-08	185898	128887224	26383336	117	10390											
SAGE1	55511	broad.mit.edu	37	chrX	134989538	134989538	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaaccgcaacctaataacgTattgtcaactgttcaaccag	5	13	2	0			TCGA-16-1045-01B-01W-0611-08	TCGA-16-1045-10B-01W-0611-08									Somatic	Phase_I	Capture				Illumina GAIIx	c92c1d87-0df9-4c5a-baef-2dd26ad6d75a	92b999aa-f557-4ff7-b5d3-81f6507f6ce1	g.chrX:134989538T>G	uc004ezh.2	+	9	1111	c.944T>G	c.(943-945)GTA>GGA	p.V315G	SAGE1_uc010nry.1_Missense_Mutation_p.V284G|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	315										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CCTAATAACGTATTGTCAACT	0.408													G	134989538	G	G	134989538	3	3	150	1	0	0	0	0	1	0	0	0	13809	1638	57	5	974	5	SAGE1	23	134989538	Missense_Mutation	SNP	T	TCGA-16-1045-01B-01W-0611-08	6102314	134989538	20281022	118	10391											
KIAA1751	85452	broad.mit.edu	37	chr1	1902133	1902133	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctcctggcgccggcgctgGtggacaaggtgcctgaatgc	16	12	0	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr1:1902133G>A	uc001aim.1	-	10	1167	c.1011C>T	c.(1009-1011)CAC>CAT	p.H337H	KIAA1751_uc009vkz.1_Silent_p.H337H	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	337	Potential.									pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GCCGGCGCTGGTGGACAAGGT	0.677													A	1902133	A	A	1902133	2	1	151	1	0	0	0	0	0	0	0	1	8256	1252	44	3		3	KIAA1751	1	1902133	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08		1902133	247348488	1	10392											
CHD5	26038	broad.mit.edu	37	chr1	6195434	6195434	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcttccttggagatgtcaGcaaactcctccaggaagccc	10	13	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr1:6195434G>A	uc001amb.1	-	18	2826	c.2726C>T	c.(2725-2727)GCT>GTT	p.A909V	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	909					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGAGATGTCAGCAAACTCCTC	0.602													A	6195434	A	A	6195434	3	1	151	1	0	0	0	0	1	0	0	0	3328	971	34	3	3234	3	CHD5	1	6195434	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	4293301	6195434	243055187	2	10393											
ZMYM4	9202	broad.mit.edu	37	chr1	35836122	35836122	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaactgcttatcagaggaaaGggtctactcagctattctgc	9	9	4	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr1:35836122G>T	uc001byt.2	+	7	1155	c.1075G>T	c.(1075-1077)GGG>TGG	p.G359W	ZMYM4_uc009vuu.2_Missense_Mutation_p.G327W|ZMYM4_uc001byu.2_Missense_Mutation_p.G35W|ZMYM4_uc009vuv.2_Missense_Mutation_p.G98W|uc001byv.2_5'Flank	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	359					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TCAGAGGAAAGGGTCTACTCA	0.483													T	35836122	T	T	35836122	3	4	151	1	0	0	0	0	1	0	0	0	17699	1000	35	5	1101	5	ZMYM4	1	35836122	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	29640688	35836122	213414499	3	10394											
EPS15	2060	broad.mit.edu	37	chr1	51869155	51869155	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagtaacagctgtagtcaccTcattttcatcagtcacacca	5	13	5	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr1:51869155T>C	uc001csq.1	-	17	1819	c.1727A>G	c.(1726-1728)GAG>GGG	p.E576G	EPS15_uc009vyz.1_Missense_Mutation_p.E442G|EPS15_uc001csp.3_Missense_Mutation_p.E262G	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	576					cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						TGTAGTCACCTCATTTTCATC	0.303			T	MLL	ALL								C	51869155	C	C	51869155	3	2	151	1	0	0	0	0	1	0	0	0	5192	1551	54	4	999	4	EPS15	1	51869155	Missense_Mutation	SNP	T	TCGA-16-1048-01B-01D-1353-08	16033033	51869155	197381466	4	10395											
ECHDC2	55268	broad.mit.edu	37	chr1	53370462	53370462	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccgtgaagatgagctccttCgccagggccacccccagaca	10	17	0	4			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr1:53370462C>T	uc001cup.3	-	7	804	c.558G>A	c.(556-558)GCG>GCA	p.A186A	ECHDC2_uc001cun.2_Silent_p.A109A|ECHDC2_uc001cuo.3_Silent_p.A155A|ECHDC2_uc010onk.1_Silent_p.A140A	NM_018281	NP_060751	Q86YB7	ECHD2_HUMAN	enoyl Coenzyme A hydratase domain containing 2	186					fatty acid metabolic process	mitochondrion	lyase activity			central_nervous_system(1)	1						TGAGCTCCTTCGCCAGGGCCA	0.642													T	53370462	T	T	53370462	2	4	151	1	0	0	0	0	0	0	0	1	4894	871	31	2		2	ECHDC2	1	53370462	Silent	SNP	C	TCGA-16-1048-01B-01D-1353-08	1501307	53370462	195880159	5	10396											
AMY2B	280	broad.mit.edu	37	chr1	104115707	104115710	+	Frame_Shift_Del	DEL	TAAT	-	-													tcgtatttatgtggatgctgTaattaatcatatgtctggta							TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr1:104115707_104115710delTAAT	uc001duq.2	+	5	954_957	c.338_341delTAAT	c.(337-342)GTAATTfs	p.V113fs	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Frame_Shift_Del_p.V113fs|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	113_114					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GTGGATGCTGTAATTAATCATATG	0.387													-	104115710	-	-	104115707	7	5	151	1	0	1	0	1	0	0	0	0	595	1638	57	0	348	0	AMY2B	1	104115707	Frame_Shift_Del	DEL	TAAT	TCGA-16-1048-01B-01D-1353-08	50745245	104115707	145134914	6	10397											
TXNIP	10628	broad.mit.edu	37	chr1	145439050	145439050	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcttctggaagaccagccaaCaggtaagcggcccaattcat	9	12	3	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr1:145439050C>A	uc001enn.3	+	1	589	c.248C>A	c.(247-249)ACA>AAA	p.T83K	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_5'Flank	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	83					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GACCAGCCAACAGGTAAGCGG	0.463													A	145439050	A	A	145439050	3	1	151	1	0	0	0	0	1	0	0	0	16800	478	17	5	250	5	TXNIP	1	145439050	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	41323343	145439050	103811571	7	10398											
OR6K2	81448	broad.mit.edu	37	chr1	158669789	158669789	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagccacaataccatcgtaGgacatgaagatgagcatcac	8	11	1	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr1:158669789G>A	uc001fsu.1	-	1	654	c.654C>T	c.(652-654)TCC>TCT	p.S218S		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	218	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TACCATCGTAGGACATGAAGA	0.478													A	158669789	A	A	158669789	2	1	151	1	0	0	0	0	0	0	0	1	11202	987	35	3		3	OR6K2	1	158669789	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	13230739	158669789	90580832	8	10399											
CNTN2	6900	broad.mit.edu	37	chr1	205042816	205042816	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtggagaacatggcagtcCgcccagcaccacaccctggc	12	15	0	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr1:205042816C>T	uc001hbr.2	+	23	3315	c.3046C>T	c.(3046-3048)CGC>TGC	p.R1016C	CNTN2_uc001hbs.2_Missense_Mutation_p.R804C	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	1016					axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CATGGCAGTCCGCCCAGCACC	0.607													T	205042816	T	T	205042816	3	4	151	1	0	0	0	0	1	0	0	0	3641	652	23	2	3132	2	CNTN2	1	205042816	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	46373027	205042816	44207805	9	10400											
EHD3	30845	broad.mit.edu	37	chr2	31483729	31483729	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagggacatccagagtctgCcccgaaatgctgccctgcgc	11	15	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:31483729C>T	uc002rnu.2	+	4	1464	c.856C>T	c.(856-858)CCC>TCC	p.P286S	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	286					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding	p.P286P(1)		skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					CCAGAGTCTGCCCCGAAATGC	0.622													T	31483729	T	T	31483729	3	4	151	1	0	0	0	0	1	0	0	0	4979	739	26	3	870	3	EHD3	2	31483729	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08		31483729	211715644	10	10401											
BIRC6	57448	broad.mit.edu	37	chr2	32727897	32727897	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgccagttatctgagccattAttgtggttcattttgagagt	10	6	2	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:32727897A>T	uc010ezu.2	+	48	9377	c.9243A>T	c.(9241-9243)TTA>TTT	p.L3081F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3081					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTGAGCCATTATTGTGGTTCA	0.313													T	32727897	T	T	32727897	3	4	151	1	0	0	0	0	1	0	0	0	1438	446	16	5	9433	5	BIRC6	2	32727897	Missense_Mutation	SNP	A	TCGA-16-1048-01B-01D-1353-08	1244168	32727897	210471476	11	10402											
SLC4A5	57835	broad.mit.edu	37	chr2	74477637	74477637	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatatccagacacaggccacCgaagaacctgctcaagacag	9	13	1	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:74477637C>T	uc002sko.1	-	12	1488	c.1486G>A	c.(1486-1488)GGT>AGT	p.G496S	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.G496S|SLC4A5_uc010ffc.1_Missense_Mutation_p.G496S|SLC4A5_uc002skp.1_Missense_Mutation_p.G432S|SLC4A5_uc002sks.1_Missense_Mutation_p.G496S	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	496	Cytoplasmic (Potential).|Gly-rich.					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						CACAGGCCACCGAAGAACCTG	0.527											OREG0014716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	74477637	T	T	74477637	3	4	151	1	0	0	0	0	1	0	0	0	14657	652	23	2	1987	2	SLC4A5	2	74477637	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	41749740	74477637	168721736	12	10403											
IL18RAP	8807	broad.mit.edu	37	chr2	103040791	103040791	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcacataagcaagacctaCttcttgggagcactggctct	8	12	3	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:103040791C>T	uc002tbx.2	+	5	980	c.496C>T	c.(496-498)CTT>TTT	p.L166F	IL18RAP_uc010fiz.2_Missense_Mutation_p.L24F	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	166	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						gcaagacctacttcttgggag	0.343													T	103040791	T	T	103040791	3	4	151	1	0	0	0	0	1	0	0	0	7648	565	20	3	506	3	IL18RAP	2	103040791	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	28563154	103040791	140158582	13	10404											
TMEM87B	84910	broad.mit.edu	37	chr2	112865416	112865416	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttccctcttcattcacagatGtgtaagttatcttctgttac	5	10	5	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:112865416G>A	uc002thm.2	+	17	1945	c.1576G>A	c.(1576-1578)GTA>ATA	p.V526I		NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	526						integral to membrane					0						ATTCACAGATGTGTAAGTTAT	0.343													A	112865416	A	A	112865416	3	1	151	1	0	0	0	0	1	0	0	0	16208	1391	48	3	1642	3	TMEM87B	2	112865416	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	9824625	112865416	130333957	14	10405											
GCG	2641	broad.mit.edu	37	chr2	163005628	163005628	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgtgtcttgaagggaacGttgccagctgccttgtacca	11	11	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:163005628G>A	uc002ucc.2	-	2	160	c.61C>T	c.(61-63)CGT>TGT	p.R21C		NM_002054	NP_002045	P01275	GLUC_HUMAN	glucagon preproprotein	21					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)	TGAAGGGAACGTTGCCAGCTG	0.413													A	163005628	A	A	163005628	3	1	151	1	0	0	0	0	1	0	0	0	6290	1145	40	1	501	1	GCG	2	163005628	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	50140212	163005628	80193745	15	10406											
MYO3B	140469	broad.mit.edu	37	chr2	171243715	171243715	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaatgacaactcgagccgtTttggaaaatatctggaaatg	9	7	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:171243715T>C	uc002ufy.2	+	14	1617	c.1474T>C	c.(1474-1476)TTT>CTT	p.F492L	MYO3B_uc002ufv.2_Missense_Mutation_p.F479L|MYO3B_uc010fqb.1_Missense_Mutation_p.F479L|MYO3B_uc002ufz.2_Missense_Mutation_p.F492L|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	492	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						CTCGAGCCGTTTTGGAAAATA	0.433													C	171243715	C	C	171243715	3	2	151	1	0	0	0	0	1	0	0	0	10077	1841	64	4	1528	4	MYO3B	2	171243715	Missense_Mutation	SNP	T	TCGA-16-1048-01B-01D-1353-08	8238087	171243715	71955658	16	10407											
ITGA4	3676	broad.mit.edu	37	chr2	182358131	182358131	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccgtgcagatgggatctcGtcaaccttctcacaggtaag	12	11	3	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:182358131G>A	uc002unu.2	+	11	1996	c.1233G>A	c.(1231-1233)TCG>TCA	p.S411S		NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	411	FG-GAP 6.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATGGGATCTCGTCAACCTTCT	0.368													A	182358131	A	A	182358131	2	1	151	1	0	0	0	0	0	0	0	1	7878	1132	40	1		1	ITGA4	2	182358131	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	11114416	182358131	60841242	17	10408											
MYO1B	4430	broad.mit.edu	37	chr2	192141643	192141643	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggccaaaatggaggtgaaaAcctcacttctggacaatatg	10	8	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:192141643A>T	uc010fsg.2	+	2	277	c.22A>T	c.(22-24)ACC>TCC	p.T8S	MYO1B_uc002usq.2_Missense_Mutation_p.T8S|MYO1B_uc002usr.2_Missense_Mutation_p.T8S|MYO1B_uc002uss.1_Missense_Mutation_p.T8S	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	8						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GGAGGTGAAAACCTCACTTCT	0.433													T	192141643	T	T	192141643	3	4	151	1	0	0	0	0	1	0	0	0	10069	43	2	5	24	5	MYO1B	2	192141643	Missense_Mutation	SNP	A	TCGA-16-1048-01B-01D-1353-08	9783512	192141643	51057730	18	10409											
SLC19A3	80704	broad.mit.edu	37	chr2	228560683	228560683	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgcccagatattggctgtgTaatgcatgagaaataaagaa	10	6	0	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:228560683T>C	uc002vpi.2	-	4	1183	c.1094A>G	c.(1093-1095)TAC>TGC	p.Y365C	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.Y361C	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	365	Extracellular (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	ATTGGCTGTGTAATGCATGAG	0.443													C	228560683	C	C	228560683	3	2	151	1	0	0	0	0	1	0	0	0	14430	1638	57	4	408	4	SLC19A3	2	228560683	Missense_Mutation	SNP	T	TCGA-16-1048-01B-01D-1353-08	36419040	228560683	14638690	19	10410											
CHRND	1144	broad.mit.edu	37	chr2	233394760	233394760	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctacctcatcatccgccGcaagcccctcttctacatca	3	19	6	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:233394760G>A	uc002vsw.2	+	7	735	c.731G>A	c.(730-732)CGC>CAC	p.R244H	CHRND_uc010zmg.1_Missense_Mutation_p.R229H|CHRND_uc010fyc.2_Missense_Mutation_p.R117H|CHRND_uc010zmh.1_Intron	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	244	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		ATCATCCGCCGCAAGCCCCTC	0.607													A	233394760	A	A	233394760	3	1	151	1	0	0	0	0	1	0	0	0	3394	1087	38	1	757	1	CHRND	2	233394760	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	4834077	233394760	9804613	20	10411											
SNED1	25992	broad.mit.edu	37	chr2	242004746	242004746	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ccgacggccctcaagatggaGagagtggaggagagtggggt	19	7	1	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr2:242004746G>A	uc002wah.1	+	21	2745	c.2745G>A	c.(2743-2745)GAG>GAA	p.E915E	SNED1_uc002wai.1_Silent_p.E150E|SNED1_uc002waj.1_Silent_p.E2E|SNED1_uc002wak.2_Silent_p.E2E	NM_001080437	NP_001073906	Q8TER0	SNED1_HUMAN	6720455I24Rik homolog precursor	915	Fibronectin type-III 1.				cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		TCAAGATGGAGAGAGTGGAGG	0.607													A	242004746	A	A	242004746	2	1	151	1	0	0	0	0	0	0	0	1	14845	933	33	3		3	SNED1	2	242004746	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	8609986	242004746	1194627	21	10412											
SLC4A7	9497	broad.mit.edu	37	chr3	27478926	27478926	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctccatctctgtaacacagTtcatccatttccgtgaagag	6	12	3	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr3:27478926T>G	uc003cdv.2	-	4	425	c.354A>C	c.(352-354)GAA>GAC	p.E118D	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.E123D|SLC4A7_uc011aww.1_Missense_Mutation_p.E127D|SLC4A7_uc011awx.1_Missense_Mutation_p.E127D|SLC4A7_uc011awy.1_Missense_Mutation_p.E123D|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.E123D|SLC4A7_uc011axb.1_Missense_Mutation_p.E127D|SLC4A7_uc010hfm.2_Missense_Mutation_p.E123D|SLC4A7_uc003cdw.2_Missense_Mutation_p.E118D	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	118	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						TGTAACACAGTTCATCCATTT	0.333													G	27478926	G	G	27478926	3	3	151	1	0	0	0	0	1	0	0	0	14658	1722	60	5	3378	5	SLC4A7	3	27478926	Missense_Mutation	SNP	T	TCGA-16-1048-01B-01D-1353-08		27478926	170543504	22	10413											
PIK3CA	5290	broad.mit.edu	37	chr3	178917478	178917478	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttatgtaattttattaaagGttttgctatcggcatgccag	8	5	0	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr3:178917478G>A	uc003fjk.2	+	3	510	c.353G>A	c.(352-354)GGT>GAT	p.G118D		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	118					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G118D(6)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTTATTAAAGGTTTTGCTATC	0.338		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178917478	A	A	178917478	3	1	151	1	0	0	0	0	1	0	0	0	11913	1275	44	3	359	3	PIK3CA	3	178917478	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	151438552	178917478	19104952	23	10414											
GABRA4	2557	broad.mit.edu	37	chr4	46930475	46930475	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagtcttgatccaaacaCgtgacgagtagaagcagatc	10	10	1	4			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr4:46930475C>T	uc003gxg.2	-	9	1571	c.1432G>A	c.(1432-1434)GTG>ATG	p.V478M		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	478	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GATCCAAACACGTGACGAGTA	0.488													T	46930475	T	T	46930475	3	4	151	1	0	0	0	0	1	0	0	0	6163	536	19	1	236	1	GABRA4	4	46930475	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08		46930475	144223801	24	10415											
C4orf35	85438	broad.mit.edu	37	chr4	71201240	71201240	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatctcaataacctctgaaGtctctggcacactaaaggac	7	11	3	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr4:71201240G>A	uc003hff.2	+	1	570	c.484G>A	c.(484-486)GTC>ATC	p.V162I		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	162						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				AACCTCTGAAGTCTCTGGCAC	0.413													A	71201240	A	A	71201240	3	1	151	1	0	0	0	0	1	0	0	0	2265	1029	36	3	486	3	C4orf35	4	71201240	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	24270765	71201240	119953036	25	10416											
SEC24B	10427	broad.mit.edu	37	chr4	110384778	110384778	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acaggatccctggctgtagcGaacaacaacccaaccattac	7	14	0	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr4:110384778G>A	uc003hzk.2	+	2	910	c.855G>A	c.(853-855)GCG>GCA	p.A285A	SEC24B_uc003hzl.2_Silent_p.A285A|SEC24B_uc011cfp.1_Silent_p.A316A|SEC24B_uc011cfq.1_Silent_p.A285A|SEC24B_uc011cfr.1_Silent_p.A285A	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	285					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TGGCTGTAGCGAACAACAACC	0.413													A	110384778	A	A	110384778	2	1	151	1	0	0	0	0	0	0	0	1	13995	1045	37	2		2	SEC24B	4	110384778	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	39183538	110384778	80769498	26	10417											
NAF1	92345	broad.mit.edu	37	chr4	164050096	164050096	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	actatctccagaagagggtgGaggaggcagtggtggagggg	20	5	1	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr4:164050096G>C	uc003iqj.2	-	8	1632	c.1438C>G	c.(1438-1440)CCA>GCA	p.P480A	NAF1_uc010iqw.1_Intron	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	480	Pro-rich.				rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				GAAgagggtggaggaggcagt	0.289													C	164050096	C	C	164050096	3	2	151	1	0	0	0	0	1	0	0	0	10140	1174	41	5	191	5	NAF1	4	164050096	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	53665318	164050096	27104180	27	10418											
PALLD	23022	broad.mit.edu	37	chr4	169433085	169433085	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccgaaaggctgaaaagcgtGgtgcaaaaactcccagcaca	10	11	0	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr4:169433085G>A	uc011cjx.1	+	2	641	c.430G>A	c.(430-432)GGT>AGT	p.G144S	PALLD_uc003iru.2_Missense_Mutation_p.G144S	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	144					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TGAAAAGCGTGGTGCAAAAAC	0.512									Pancreatic_Cancer_Familial_Clustering_of				A	169433085	A	A	169433085	3	1	151	1	0	0	0	0	1	0	0	0	11407	1348	47	3	432	3	PALLD	4	169433085	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	5382989	169433085	21721191	28	10419											
LRP2BP	55805	broad.mit.edu	37	chr4	186299262	186299262	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcctttttccactggaaaaAtttttggtttttagcagcat	6	7	0	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr4:186299262A>C	uc003ixj.1	-	1	891	c.79T>G	c.(79-81)TTT>GTT	p.F27V	LRP2BP_uc003ixk.1_5'UTR|LRP2BP_uc011ckr.1_Missense_Mutation_p.F27V	NM_018409	NP_060879	Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	27						cytoplasm	protein binding				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		CACTGGAAAAATTTTTGGTTT	0.378													C	186299262	C	C	186299262	3	2	151	1	0	0	0	0	1	0	0	0	8957	101	4	5	996	5	LRP2BP	4	186299262	Missense_Mutation	SNP	A	TCGA-16-1048-01B-01D-1353-08	16866177	186299262	4855014	29	10420											
MARVELD2	153562	broad.mit.edu	37	chr5	68737366	68737366	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttcttttacaggatcctaCatttctggaaaaaaaagaac	5	7	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr5:68737366C>T	uc003jwq.2	+	7	1621	c.1562C>T	c.(1561-1563)ACA>ATA	p.T521I	MARVELD2_uc010ixf.2_Missense_Mutation_p.T509I|MARVELD2_uc003jwr.1_Intron|MARVELD2_uc003jws.1_RNA	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	521	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		CAGGATCCTACATTTCTGGAA	0.318													T	68737366	T	T	68737366	3	4	151	1	0	0	0	0	1	0	0	0	9318	478	17	3	1584	3	MARVELD2	5	68737366	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08		68737366	112177894	30	10421											
FBN2	2201	broad.mit.edu	37	chr5	127728993	127728993	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atttcccccagtgcctccagGtctggaaccagcactccctg	8	17	1	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr5:127728993G>T	uc003kuu.2	-	10	1739	c.1300C>A	c.(1300-1302)CCT>ACT	p.P434T	FBN2_uc003kuv.2_Missense_Mutation_p.P401T	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	434					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GTGCCTCCAGGTCTGGAACCA	0.532													T	127728993	T	T	127728993	3	4	151	1	0	0	0	0	1	0	0	0	5703	1261	44	5	7662	5	FBN2	5	127728993	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	58991627	127728993	53186267	31	10422											
PDLIM4	8572	broad.mit.edu	37	chr5	131607724	131607724	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gttccccccatcaggggcacCatcgtcaaggcacgggacaa	11	15	2	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr5:131607724C>G	uc003kwn.2	+	7	872	c.795C>G	c.(793-795)ACC>ACG	p.T265T	uc003kwm.3_Intron|PDLIM4_uc003kwp.2_Missense_Mutation_p.P226R|PDLIM4_uc003kwo.2_Silent_p.T373T	NM_003687	NP_003678	P50479	PDLI4_HUMAN	PDZ and LIM domain 4 isoform 1	265	LIM zinc-binding.						protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCAGGGGCACCATCGTCAAGG	0.617													G	131607724	G	G	131607724	2	3	151	1	0	0	0	0	0	0	0	1	11682	594	21	5		5	PDLIM4	5	131607724	Silent	SNP	C	TCGA-16-1048-01B-01D-1353-08	3878731	131607724	49307536	32	10423											
PCDHGA8	9708	broad.mit.edu	37	chr5	140774290	140774290	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccctgctggacagagatgCgctcaagcagagcctcgtgg	14	12	1	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr5:140774290C>T	uc003lkd.1	+	1	2808	c.1910C>T	c.(1909-1911)GCG>GTG	p.A637V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.A637V	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	637	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAGAGATGCGCTCAAGCAG	0.682													T	140774290	T	T	140774290	3	4	151	1	0	0	0	0	1	0	0	0	11560	768	27	1	1912	1	PCDHGA8	5	140774290	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	9166566	140774290	40140970	33	10424											
DSP	1832	broad.mit.edu	37	chr6	7580369	7580369	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaagcagtccctggaggagGctgccaagaccattcaggac	12	12	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:7580369G>A	uc003mxp.1	+	23	4225	c.3946G>A	c.(3946-3948)GCT>ACT	p.A1316T	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1316	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CCTGGAGGAGGCTGCCAAGAC	0.512													A	7580369	A	A	7580369	3	1	151	1	0	0	0	0	1	0	0	0	4781	1203	42	3	4036	3	DSP	6	7580369	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08		7580369	163534698	34	10425											
COL11A2	1302	broad.mit.edu	37	chr6	33137189	33137189	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttggggccatcatcgcctgTggggcctttaggccctggtg	15	11	1	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:33137189T>C	uc003ocx.1	-	51	3997	c.3769A>G	c.(3769-3771)ACA>GCA	p.T1257A	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.T1171A|COL11A2_uc003ocz.1_Missense_Mutation_p.T1150A	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1257	Triple-helical region.			T -> Q (in Ref. 1; AAC50213/AAC50214/ AAC50215 and 6; AAA52034).	cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TCATCGCCTGTGGGGCCTTTA	0.627													C	33137189	C	C	33137189	3	2	151	1	0	0	0	0	1	0	0	0	3668	1696	59	4	1505	4	COL11A2	6	33137189	Missense_Mutation	SNP	T	TCGA-16-1048-01B-01D-1353-08	25556820	33137189	137977878	35	10426											
KCNK17	89822	broad.mit.edu	37	chr6	39272395	39272395	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaagaagatgcagaagaggCgggcagccatcgtgttgggg	17	7	0	4	rs142227833		TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:39272395C>T	uc003ooo.2	-	3	529	c.389G>A	c.(388-390)CGC>CAC	p.R130H	KCNK17_uc003oop.2_Missense_Mutation_p.R130H	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	130	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						GCAGAAGAGGCGGGCAGCCAT	0.612													T	39272395	T	T	39272395	3	4	151	1	0	0	0	0	1	0	0	0	8064	768	27	1	753	1	KCNK17	6	39272395	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	6135206	39272395	131842672	36	10427											
PTK7	5754	broad.mit.edu	37	chr6	43109453	43109453	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagacaacgctgggaccctgCattttgcccgggtgactcga	12	13	0	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:43109453C>T	uc003oub.1	+	11	1864	c.1666C>T	c.(1666-1668)CAT>TAT	p.H556Y	PTK7_uc003ouc.1_Missense_Mutation_p.H556Y|PTK7_uc003oud.1_Missense_Mutation_p.H516Y|PTK7_uc003oue.1_Missense_Mutation_p.H426Y|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Missense_Mutation_p.H564Y|PTK7_uc010jyj.1_Intron	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	556	Ig-like C2-type 6.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			TGGGACCCTGCATTTTGCCCG	0.582													T	43109453	T	T	43109453	3	4	151	1	0	0	0	0	1	0	0	0	12765	710	25	3	1708	3	PTK7	6	43109453	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	3837058	43109453	128005614	37	10428											
TINAG	27283	broad.mit.edu	37	chr6	54191661	54191661	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tagaagatggttttaaatttCgccttggcactttgccacct	8	9	0	2	rs115438249	byFrequency	TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:54191661C>T	uc003pcj.2	+	4	717	c.571C>T	c.(571-573)CGC>TGC	p.R191C	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	191					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TTTTAAATTTCGCCTTGGCAC	0.373													T	54191661	T	T	54191661	3	4	151	1	0	0	0	0	1	0	0	0	15918	884	31	2	585	2	TINAG	6	54191661	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	11082208	54191661	116923406	38	10429											
TINAG	27283	broad.mit.edu	37	chr6	54254704	54254704	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcagcttggggccaactgaCgagttctgatgaaccataac	11	11	1	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:54254704C>T	uc003pcj.2	+	11	1558	c.1412C>T	c.(1411-1413)ACG>ATG	p.T471M	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	471					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			GGCCAACTGACGAGTTCTGAT	0.403													T	54254704	T	T	54254704	3	4	151	1	0	0	0	0	1	0	0	0	15918	536	19	1	1454	1	TINAG	6	54254704	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	63043	54254704	116860363	39	10430											
RIMS1	22999	broad.mit.edu	37	chr6	72993805	72993805	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aacagactaggaaaggcactGcctctgatgcagaaaggtag	12	8	1	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:72993805G>T	uc003pga.2	+	24	3615	c.3538G>T	c.(3538-3540)GCC>TCC	p.A1180S	RIMS1_uc011dyb.1_Intron|RIMS1_uc003pgc.2_Intron|RIMS1_uc010kaq.2_Missense_Mutation_p.A561S|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Missense_Mutation_p.A481S|RIMS1_uc011dyd.1_Missense_Mutation_p.A547S|RIMS1_uc003pgf.2_Intron|RIMS1_uc003pgg.2_Intron|RIMS1_uc003pgi.2_Intron|RIMS1_uc003pgh.2_Intron|RIMS1_uc003pgd.2_Intron|RIMS1_uc003pge.2_Intron|RIMS1_uc011dye.1_Missense_Mutation_p.A37S|RIMS1_uc011dyf.1_Missense_Mutation_p.A37S	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1180					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GAAAGGCACTGCCTCTGATGC	0.398													T	72993805	T	T	72993805	3	4	151	1	0	0	0	0	1	0	0	0	13367	1319	46	5	3795	5	RIMS1	6	72993805	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	18739101	72993805	98121262	40	10431											
MAP3K7	6885	broad.mit.edu	37	chr6	91226312	91226312	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agtagaaaggcttttgttttCatctaaaagctttttatgtt	7	4	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:91226312C>A	uc003pnz.1	-	17	1891	c.1729G>T	c.(1729-1731)GAA>TAA	p.E577*	MAP3K7_uc003pny.1_Nonsense_Mutation_p.E114*|MAP3K7_uc003poa.1_3'UTR|MAP3K7_uc003pob.1_Nonsense_Mutation_p.E550*|MAP3K7_uc003poc.1_3'UTR	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	577					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTTTTGTTTTCATCTAAAAGC	0.408													A	91226312	A	A	91226312	4	1	151	1	0	0	0	0	0	1	0	0	9255	835	29	5	95	5	MAP3K7	6	91226312	Nonsense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	18232507	91226312	79888755	41	10432											
LAMA4	3910	broad.mit.edu	37	chr6	112496666	112496666	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgctcttccccataatagagCatcttgttgttgatctctga	7	10	3	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:112496666C>A	uc003pvu.2	-	11	1515	c.1206G>T	c.(1204-1206)ATG>ATT	p.M402I	LAMA4_uc003pvv.2_Missense_Mutation_p.M395I|LAMA4_uc003pvt.2_Missense_Mutation_p.M395I	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	402	Potential.|Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CATAATAGAGCATCTTGTTGT	0.483													A	112496666	A	A	112496666	3	1	151	1	0	0	0	0	1	0	0	0	8608	710	25	5	4381	5	LAMA4	6	112496666	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	21270354	112496666	58618401	42	10433											
DSE	29940	broad.mit.edu	37	chr6	116757126	116757126	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagctgcttttctccctggGtgggtcaggtcacagaagac	13	10	3	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr6:116757126G>A	uc003pws.2	+	6	1689	c.1495G>A	c.(1495-1497)GTG>ATG	p.V499M	DSE_uc011ebg.1_Missense_Mutation_p.V518M|DSE_uc003pwt.2_Missense_Mutation_p.V499M|DSE_uc003pwu.2_Missense_Mutation_p.V166M	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	499					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TTCTCCCTGGGTGGGTCAGGT	0.483													A	116757126	A	A	116757126	3	1	151	1	0	0	0	0	1	0	0	0	4774	1261	44	3	1513	3	DSE	6	116757126	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	4260460	116757126	54357941	43	10434											
COL28A1	340267	broad.mit.edu	37	chr7	7412801	7412801	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accacctctgtcagtttctcTttatcacgagaatctgtctg	6	12	6	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr7:7412801T>C	uc003src.1	-	32	2853	c.2736A>G	c.(2734-2736)AAA>AAG	p.K912K	COL28A1_uc011jxe.1_Silent_p.K595K	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	912	VWFA 2.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TCAGTTTCTCTTTATCACGAG	0.443													C	7412801	C	C	7412801	2	2	151	1	0	0	0	0	0	0	0	1	3686	1606	56	4		4	COL28A1	7	7412801	Silent	SNP	T	TCGA-16-1048-01B-01D-1353-08		7412801	151725862	44	10435											
C7orf57	136288	broad.mit.edu	37	chr7	48081010	48081010	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcccagatcccaggtctcagCaatttgggagactcacacag	9	13	2	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr7:48081010C>G	uc003toh.3	+	3	347	c.135C>G	c.(133-135)AGC>AGG	p.S45R	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	45										ovary(1)	1						CAGGTCTCAGCAATTTGGGAG	0.537													G	48081010	G	G	48081010	3	3	151	1	0	0	0	0	1	0	0	0	2404	709	25	5	141	5	C7orf57	7	48081010	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	40668209	48081010	111057653	45	10436											
EGFR	1956	broad.mit.edu	37	chr7	55221716	55221716	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctccataggtctgccgcaaaTtccgagacgaagccacgtgc	10	14	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr7:55221716T>A	uc003tqk.2	+	7	1006	c.760T>A	c.(760-762)TTC>ATC	p.F254I	EGFR_uc003tqh.2_Missense_Mutation_p.F254I|EGFR_uc003tqi.2_Missense_Mutation_p.F254I|EGFR_uc003tqj.2_Missense_Mutation_p.F254I|EGFR_uc010kzg.1_Missense_Mutation_p.F209I|EGFR_uc011kco.1_Missense_Mutation_p.F201I|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	254	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.F254F(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTGCCGCAAATTCCGAGACGA	0.587		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55221716	A	A	55221716	3	1	151	1	0	0	0	0	1	0	0	0	4967	1493	52	5	786	5	EGFR	7	55221716	Missense_Mutation	SNP	T	TCGA-16-1048-01B-01D-1353-08	7140706	55221716	103916947	46	10437											
WBSCR17	64409	broad.mit.edu	37	chr7	71135089	71135089	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaataataccgttgcttacGgggaggtaattcagaccgtg	11	8	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr7:71135089G>A	uc003tvy.2	+	8	1399	c.1399G>A	c.(1399-1401)GGG>AGG	p.G467R	WBSCR17_uc003tvz.2_Missense_Mutation_p.G166R	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	467	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CGTTGCTTACGGGGAGGTAAT	0.413													A	71135089	A	A	71135089	3	1	151	1	0	0	0	0	1	0	0	0	17261	1116	39	2	1429	2	WBSCR17	7	71135089	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	15913373	71135089	88003574	47	10438											
SAMD9	54809	broad.mit.edu	37	chr7	92733048	92733048	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtacaggtacgtattcctgaCggttcattgccccataggtg	11	10	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr7:92733048C>T	uc003umf.2	-	3	2619	c.2363G>A	c.(2362-2364)CGT>CAT	p.R788H	SAMD9_uc003umg.2_Missense_Mutation_p.R788H	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	788						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GTATTCCTGACGGTTCATTGC	0.378													T	92733048	T	T	92733048	3	4	151	1	0	0	0	0	1	0	0	0	13826	536	19	1	2410	1	SAMD9	7	92733048	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	21597959	92733048	66405615	48	10439											
TRIM56	81844	broad.mit.edu	37	chr7	100730794	100730794	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagacagtgcctgtgccgccCgagggtgtggcctccttcaa	14	13	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr7:100730794C>T	uc003uxq.2	+	3	432	c.201C>T	c.(199-201)CCC>CCT	p.P67P	TRIM56_uc003uxr.2_Silent_p.P67P	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	67					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGTGCCGCCCGAGGGTGTGG	0.677													T	100730794	T	T	100730794	2	4	151	1	0	0	0	0	0	0	0	1	16527	639	23	2		2	TRIM56	7	100730794	Silent	SNP	C	TCGA-16-1048-01B-01D-1353-08	7997746	100730794	58407869	49	10440											
RELN	5649	broad.mit.edu	37	chr7	103159906	103159906	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cccatacatgaagtaaaattGgatgaactcagcattagtga	8	7	1	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr7:103159906G>T	uc003vca.2	-	49	7886	c.7726C>A	c.(7726-7728)CAA>AAA	p.Q2576K	RELN_uc010liz.2_Missense_Mutation_p.Q2576K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2576					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAGTAAAATTGGATGAACTCA	0.378													T	103159906	T	T	103159906	3	4	151	1	0	0	0	0	1	0	0	0	13220	1357	47	5	2724	5	RELN	7	103159906	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	2429112	103159906	55978757	50	10441											
DLGAP2	9228	broad.mit.edu	37	chr8	1649565	1649565	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catccccgaggcccagacccGgctctgagggcggaggccgg	16	16	1	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr8:1649565G>A	uc003wpl.2	+	12	3018	c.2921G>A	c.(2920-2922)CGG>CAG	p.R974Q	DLGAP2_uc003wpm.2_Missense_Mutation_p.R960Q	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	1053					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GCCCAGACCCGGCTCTGAGGG	0.706													A	1649565	A	A	1649565	3	1	151	1	0	0	0	0	1	0	0	0	4560	1116	39	2	2963	2	DLGAP2	8	1649565	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08		1649565	144714457	51	10442											
ADAM28	10863	broad.mit.edu	37	chr8	24199150	24199150	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgttctgtcaaggtgggtcGgataatttgccctggaaagg	14	6	2	0	rs145453785	byFrequency	TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr8:24199150G>A	uc003xdy.2	+	16	1793	c.1710G>A	c.(1708-1710)TCG>TCA	p.S570S	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Silent_p.S257S	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	570	Extracellular (Potential).|Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AAGGTGGGTCGGATAATTTGC	0.413													A	24199150	A	A	24199150	2	1	151	1	0	0	0	0	0	0	0	1	246	1103	39	2		2	ADAM28	8	24199150	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	22549585	24199150	122164872	52	10443											
ARHGAP39	80728	broad.mit.edu	37	chr8	145771184	145771184	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgaactgggcacaggcagcgAggtcctcagactgagaagga	15	10	1	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr8:145771184A>G	uc003zdt.1	-	7	2525	c.1970T>C	c.(1969-1971)CTC>CCC	p.L657P	ARHGAP39_uc011llk.1_Missense_Mutation_p.L657P|ARHGAP39_uc003zds.1_Missense_Mutation_p.L657P	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	657					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						ACAGGCAGCGAGGTCCTCAGA	0.672													G	145771184	G	G	145771184	3	3	151	1	0	0	0	0	1	0	0	0	884	304	11	4	1402	4	ARHGAP39	8	145771184	Missense_Mutation	SNP	A	TCGA-16-1048-01B-01D-1353-08	121572034	145771184	592838	53	10444											
FREM1	158326	broad.mit.edu	37	chr9	14784500	14784500	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attcgatctggccatatcgcGgaggggaggtgatgacatag	15	7	1	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr9:14784500G>A	uc003zlm.2	-	24	4900	c.4310C>T	c.(4309-4311)CCG>CTG	p.P1437L	FREM1_uc010mic.2_Intron	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1437	CSPG 10.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GCCATATCGCGGAGGGGAGGT	0.488													A	14784500	A	A	14784500	3	1	151	1	0	0	0	0	1	0	0	0	6044	1116	39	2	2335	2	FREM1	9	14784500	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08		14784500	126428931	54	10445											
FOXD4L5	653427	broad.mit.edu	37	chr9	70177746	70177747	+	In_Frame_Ins	INS	-	GCC	GCC													aactctgaggggtcactcggINSgccgccgccgccctcgatgt							TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr9:70177746_70177747insGCC	uc010moc.2	-	1	1069_1070	c.237_238insGGC	c.(235-240)insGGC	p.79_80insG		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	79_80					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GGGTCACTCGGGCCGCCGCCGC	0.688													GCC	70177747	GCC	GCC	70177746	7	5	151	1	0	1	1	0	0	0	0	0	6002	1232	43	0	1016	0	FOXD4L5	9	70177746	In_Frame_Ins	INS	-	TCGA-16-1048-01B-01D-1353-08	55393246	70177746	71035685	55	10446											
ZMIZ1	57178	broad.mit.edu	37	chr10	81065892	81065892	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtcaccatcgatcccacgtGcagctggcggccggtgccca	13	16	1	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr10:81065892G>T	uc001kaf.2	+	22	3031	c.2459G>T	c.(2458-2460)TGC>TTC	p.C820F	ZMIZ1_uc001kag.2_Missense_Mutation_p.C696F|ZMIZ1_uc010qlq.1_5'UTR	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	820					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GATCCCACGTGCAGCTGGCGG	0.607													T	81065892	T	T	81065892	3	4	151	1	0	0	0	0	1	0	0	0	17693	1319	46	5	2529	5	ZMIZ1	10	81065892	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08		81065892	54468855	56	10447											
PNLIP	5406	broad.mit.edu	37	chr10	118307871	118307871	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacacttttctgtctaaacaGgaagttgccgcagattcatc	7	10	3	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr10:118307871G>A	uc001lcm.2	+	4	245	c.202_splice	c.e4-1	p.E68_splice		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor						lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGTCTAAACAGGAAGTTGCCG	0.388													A	118307871	A	A	118307871	5	1	151	1	0	0	0	0	0	0	1	0	12149	1014	35	3	211	3	PNLIP	10	118307871	Splice_Site	SNP	G	TCGA-16-1048-01B-01D-1353-08	37241979	118307871	17226876	57	10448											
KIAA1598	57698	broad.mit.edu	37	chr10	118728202	118728202	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttttttaacggcttcatctcGttcttgcctaattttgtcac	5	10	4	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr10:118728202G>T	uc009xyw.2	-	3	631	c.133C>A	c.(133-135)CGA>AGA	p.R45R	KIAA1598_uc001lcz.3_Silent_p.R45R|KIAA1598_uc010qso.1_5'UTR|KIAA1598_uc010qsp.1_Silent_p.R45R|KIAA1598_uc010qsq.1_5'UTR|KIAA1598_uc001lcy.3_Silent_p.R15R	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	45	Potential.				axon guidance	axon					0				all cancers(201;0.00494)		GCTTCATCTCGTTCTTGCCTA	0.318													T	118728202	T	T	118728202	2	4	151	1	0	0	0	0	0	0	0	1	8246	1153	40	5		5	KIAA1598	10	118728202	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	420331	118728202	16806545	58	10449											
STIM1	6786	broad.mit.edu	37	chr11	4045179	4045179	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtgaggataagctcatcaGcgtggaggacctgtggaagg	17	6	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr11:4045179G>A	uc001lyv.2	+	3	915	c.347G>A	c.(346-348)AGC>AAC	p.S116N	STIM1_uc009yef.2_Missense_Mutation_p.S116N	NM_003156	NP_003147	Q13586	STIM1_HUMAN	stromal interaction molecule 1 precursor	116	Extracellular (Potential).				activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			pancreas(1)	1		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		AAGCTCATCAGCGTGGAGGAC	0.488													A	4045179	A	A	4045179	3	1	151	1	0	0	0	0	1	0	0	0	15282	971	34	3	357	3	STIM1	11	4045179	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08		4045179	130961337	59	10450											
OR8I2	120586	broad.mit.edu	37	chr11	55861310	55861310	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgattccagcatcaatcattTtttttgtgacaccacagctc	5	11	2	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr11:55861310T>C	uc010rix.1	+	1	527	c.527T>C	c.(526-528)TTT>TCT	p.F176S		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					ATCAATCATTTTTTTTGTGAC	0.443													C	55861310	C	C	55861310	3	2	151	1	0	0	0	0	1	0	0	0	11240	1841	64	4	529	4	OR8I2	11	55861310	Missense_Mutation	SNP	T	TCGA-16-1048-01B-01D-1353-08	51816131	55861310	79145206	60	10451											
SLC22A9	114571	broad.mit.edu	37	chr11	63137793	63137793	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acatgaggccagagaagtgtCgtcgctttgttcatcctcag	11	10	2	2	rs143461929	by1000genomes	TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr11:63137793C>T	uc001nww.2	+	1	533	c.265C>T	c.(265-267)CGT>TGT	p.R89C	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	89	Extracellular (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						AGAGAAGTGTCGTCGCTTTGT	0.537													T	63137793	T	T	63137793	3	4	151	1	0	0	0	0	1	0	0	0	14461	884	31	2	267	2	SLC22A9	11	63137793	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	7276483	63137793	71868723	61	10452											
TSGA10IP	254187	broad.mit.edu	37	chr11	65714723	65714723	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccatgccctcctcgttctccCagcgtcagtccaggcgcaag	9	18	2	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr11:65714723C>T	uc001ogk.1	+	5	459	c.427C>T	c.(427-429)CAG>TAG	p.Q143*	TSGA10IP_uc009yqw.1_RNA|TSGA10IP_uc009yqx.1_Intron	NM_152762	NP_689975	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein	143											0						CTCGTTCTCCCAGCGTCAGTC	0.657													T	65714723	T	T	65714723	4	4	151	1	0	0	0	0	0	1	0	0	16615	595	21	3	437	3	TSGA10IP	11	65714723	Nonsense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	2576930	65714723	69291793	62	10453											
MOGAT2	80168	broad.mit.edu	37	chr11	75439862	75439862	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctggtgccaatcttctccttCggggagaatgacctatttga	10	10	2	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr11:75439862C>T	uc010rru.1	+	5	678	c.678C>T	c.(676-678)TTC>TTT	p.F226F	MOGAT2_uc001oww.1_3'UTR|MOGAT2_uc010rrv.1_Silent_p.F144F	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	226					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					TCTTCTCCTTCGGGGAGAATG	0.537													T	75439862	T	T	75439862	2	4	151	1	0	0	0	0	0	0	0	1	9695	883	31	2		2	MOGAT2	11	75439862	Silent	SNP	C	TCGA-16-1048-01B-01D-1353-08	9725139	75439862	59566654	63	10454											
GDPD4	220032	broad.mit.edu	37	chr11	76990356	76990356	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagcattactcaccaacaGcaatgaagagtaggcagtca	9	9	2	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr11:76990356G>A	uc001oyf.2	-	3	393	c.142C>T	c.(142-144)CTG>TTG	p.L48L		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	48	Helical; (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						CTCACCAACAGCAATGAAGAG	0.433													A	76990356	A	A	76990356	2	1	151	1	0	0	0	0	0	0	0	1	6326	962	34	3		3	GDPD4	11	76990356	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	1550494	76990356	58016160	64	10455											
AMOTL1	154810	broad.mit.edu	37	chr11	94532995	94532995	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcaacagcagcagggggcGgtgggccatggttactacat	15	10	0	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr11:94532995G>A	uc001pfb.2	+	3	809	c.639G>A	c.(637-639)GCG>GCA	p.A213A	AMOTL1_uc001pfc.2_Silent_p.A163A	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	213						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				agcagGGGGCGGTGGGCCATG	0.532													A	94532995	A	A	94532995	2	1	151	1	0	0	0	0	0	0	0	1	583	1103	39	2		2	AMOTL1	11	94532995	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	17542639	94532995	40473521	65	10456											
CLDN25	644672	broad.mit.edu	37	chr11	113650759	113650759	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggagctccaggtagcccGcatcctcatggtagcctccc	10	17	1	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr11:113650759G>A	uc009yyw.1	+	1	242	c.242G>A	c.(241-243)CGC>CAC	p.R81H		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	81	Extracellular (Potential).					integral to membrane|tight junction	structural molecule activity				0						CAGGTAGCCCGCATCCTCATG	0.557													A	113650759	A	A	113650759	3	1	151	1	0	0	0	0	1	0	0	0	3485	1087	38	1	244	1	CLDN25	11	113650759	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	19117764	113650759	21355757	66	10457											
AQP5	362	broad.mit.edu	37	chr12	50355944	50355944	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcctgcagatcgcgctggcGtttggcctggccataggcac	13	13	0	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr12:50355944G>A	uc001rvo.2	+	1	666	c.144G>A	c.(142-144)GCG>GCA	p.A48A		NM_001651	NP_001642	P55064	AQP5_HUMAN	aquaporin 5	48	Helical; (Potential).				carbon dioxide transport|excretion|odontogenesis|pancreatic juice secretion	apical plasma membrane|integral to plasma membrane	protein binding|water channel activity				0						TCGCGCTGGCGTTTGGCCTGG	0.667													A	50355944	A	A	50355944	2	1	151	1	0	0	0	0	0	0	0	1	829	1132	40	1		1	AQP5	12	50355944	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08		50355944	83495951	67	10458											
HSD17B6	8630	broad.mit.edu	37	chr12	57167873	57167873	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtctgacaggctggagacGgtgaccctggatgttaccaa	13	10	1	3	rs147344470	byFrequency	TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr12:57167873G>A	uc001smg.1	+	2	347	c.237G>A	c.(235-237)ACG>ACA	p.T79T		NM_003725	NP_003716	O14756	H17B6_HUMAN	hydroxysteroid (17-beta) dehydrogenase 6	79					androgen biosynthetic process|androgen catabolic process	early endosome membrane|endoplasmic reticulum|microsome	binding|electron carrier activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			upper_aerodigestive_tract(1)|pancreas(1)	2					Succinic acid(DB00139)	GGCTGGAGACGGTGACCCTGG	0.567													A	57167873	A	A	57167873	2	1	151	1	0	0	0	0	0	0	0	1	7387	1103	39	2		2	HSD17B6	12	57167873	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	6811929	57167873	76684022	68	10459											
NOS1	4842	broad.mit.edu	37	chr12	117669899	117669899	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctggaagatggtgcagggCgggaggcggagctcgtctgt	20	8	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr12:117669899C>T	uc001twm.1	-	22	3959	c.3273G>A	c.(3271-3273)CCG>CCA	p.P1091P		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1091	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGGTGCAGGGCGGGAGGCGGA	0.602													T	117669899	T	T	117669899	2	4	151	1	0	0	0	0	0	0	0	1	10541	755	27	1		1	NOS1	12	117669899	Silent	SNP	C	TCGA-16-1048-01B-01D-1353-08	60502026	117669899	16181996	69	10460											
TSC22D1	8848	broad.mit.edu	37	chr13	45148388	45148388	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gcactggaggagccgcctgaGaatatggtagctggggttga	17	7	0	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr13:45148388G>T	uc001uzn.3	-	1	2314	c.1823C>A	c.(1822-1824)TCT>TAT	p.S608Y	TSC22D1_uc001uzo.1_Intron	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	608	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		AGCCGCCTGAGAATATGGTAG	0.522													T	45148388	T	T	45148388	3	4	151	1	0	0	0	0	1	0	0	0	16604	942	33	5	1539	5	TSC22D1	13	45148388	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08		45148388	70021490	70	10461											
TUBGCP3	10426	broad.mit.edu	37	chr13	113176787	113176787	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagcagcatcaatcttccccTgaaatgcattttccaagtct	5	12	3	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr13:113176787T>C	uc001vse.1	-	14	1779	c.1592A>G	c.(1591-1593)CAG>CGG	p.Q531R	TUBGCP3_uc010tjq.1_Missense_Mutation_p.Q521R|TUBGCP3_uc001vsf.2_Missense_Mutation_p.Q531R	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	531					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					AATCTTCCCCTGAAATGCATT	0.423													C	113176787	C	C	113176787	3	2	151	1	0	0	0	0	1	0	0	0	16764	1580	55	4	1167	4	TUBGCP3	13	113176787	Missense_Mutation	SNP	T	TCGA-16-1048-01B-01D-1353-08	68028399	113176787	1993091	71	10462											
ZNF828	283489	broad.mit.edu	37	chr13	115090500	115090500	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agtcatggaagtctggcccaCcagaactccgaaagacagct	10	12	2	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr13:115090500C>G	uc010ahb.2	+	3	1512	c.1183C>G	c.(1183-1185)CCA>GCA	p.P395A	ZNF828_uc001vuv.2_Missense_Mutation_p.P395A|ZNF828_uc010tko.1_Missense_Mutation_p.P395A	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	395	Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		GTCTGGCCCACCAGAACTCCG	0.557													G	115090500	G	G	115090500	3	3	151	1	0	0	0	0	1	0	0	0	18178	507	18	5	1185	5	ZNF828	13	115090500	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	1913713	115090500	79378	72	10463											
AK7	122481	broad.mit.edu	37	chr14	96875256	96875256	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgacggtgatgacttgggCgcgctccaaagccctggacc	14	13	0	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr14:96875256C>T	uc001yfn.2	+	4	520	c.476C>T	c.(475-477)GCG>GTG	p.A159V		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	159	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		ATGACTTGGGCGCGCTCCAAA	0.473													T	96875256	T	T	96875256	3	4	151	1	0	0	0	0	1	0	0	0	444	768	27	1	490	1	AK7	14	96875256	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08		96875256	10474284	73	10464											
AHNAK2	113146	broad.mit.edu	37	chr14	105407228	105407228	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tacctgaccaagagaaacagGaatcatggaattcagtgggc	11	8	2	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr14:105407228G>C	uc010axc.1	-	7	14680	c.14560C>G	c.(14560-14562)CCT>GCT	p.P4854A	AHNAK2_uc001ypx.2_Missense_Mutation_p.P4754A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4854						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGAGAAACAGGAATCATGGAA	0.483													C	105407228	C	C	105407228	3	2	151	1	0	0	0	0	1	0	0	0	415	1174	41	5	2831	5	AHNAK2	14	105407228	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	8531972	105407228	1942312	74	10465											
NDN	4692	broad.mit.edu	37	chr15	23932352	23932352	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agggtcgctcagatccttacTttgttctgacatgtctgcgc	10	11	3	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr15:23932352T>A	uc001ywk.2	-	1	99	c.13A>T	c.(13-15)AGT>TGT	p.S5C		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	5					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		AGATCCTTACTTTGTTCTGAC	0.642									Prader-Willi_syndrome				A	23932352	A	A	23932352	3	1	151	1	0	0	0	0	1	0	0	0	10247	1609	56	5	956	5	NDN	15	23932352	Missense_Mutation	SNP	T	TCGA-16-1048-01B-01D-1353-08		23932352	78599040	75	10466											
CHRFAM7A	89832	broad.mit.edu	37	chr15	30659651	30659651	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcttgcccccgtcggggtcGtggtggtggtactgcagcac	15	12	1	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr15:30659651G>A	uc001zdt.1	-	9	1256	c.690C>T	c.(688-690)CAC>CAT	p.H230H	DKFZP434L187_uc001zds.2_Intron|CHRFAM7A_uc001zdu.1_Silent_p.H139H|CHRFAM7A_uc010azn.2_Silent_p.H139H	NM_139320	NP_647536	Q494W8	CRFM7_HUMAN	CHRNA7-FAM7A fusion isoform 1	230						integral to membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity			skin(1)	1		all_lung(180;3.42e-11)|Breast(32;0.000153)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		CGTCGGGGTCGTGGTGGTGGT	0.602													A	30659651	A	A	30659651	2	1	151	1	0	0	0	0	0	0	0	1	3375	1136	40	1		1	CHRFAM7A	15	30659651	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	6727299	30659651	71871741	76	10467											
MNS1	55329	broad.mit.edu	37	chr15	56735891	56735893	+	In_Frame_Del	DEL	TCT	-	-													cttgaacttttgccatccgaTcttcttctctttgctgctgc							TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr15:56735891_56735893delTCT	uc002adr.2	-	6	1011_1013	c.846_848delAGA	c.(844-849)GAAGAT>GAT	p.E282del	MNS1_uc010bfo.2_In_Frame_Del_p.E150del|TEX9_uc002adp.2_Intron|TEX9_uc010ugl.1_Intron	NM_018365	NP_060835	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	282	Potential.|Glu-rich.				meiosis					ovary(1)	1				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		TGCCATCCGATCTTCTTCTCTTT	0.369													-	56735893	-	-	56735891	7	5	151	1	0	1	0	1	0	0	0	0	9677	1435	50	0	659	0	MNS1	15	56735891	In_Frame_Del	DEL	TCT	TCGA-16-1048-01B-01D-1353-08	26076240	56735891	45795501	77	10468											
ARID3B	10620	broad.mit.edu	37	chr15	74884098	74884098	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtgcagcaggccttccagCgcaactttttcagcatggca	11	12	1	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr15:74884098C>T	uc002aye.2	+	7	1564	c.1363C>T	c.(1363-1365)CGC>TGC	p.R455C	ARID3B_uc002ayd.2_Missense_Mutation_p.R455C|ARID3B_uc010bjs.1_Missense_Mutation_p.R160C	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	455	REKLES.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						GGCCTTCCAGCGCAACTTTTT	0.647													T	74884098	T	T	74884098	3	4	151	1	0	0	0	0	1	0	0	0	917	768	27	1	1385	1	ARID3B	15	74884098	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	18148207	74884098	27647294	78	10469											
SRRM2	23524	broad.mit.edu	37	chr16	2812074	2812074	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgatctccccagtggcgtagGtccaggtctgcacagaggtg	14	12	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr16:2812074G>A	uc002crk.2	+	11	2094	c.1545G>A	c.(1543-1545)AGG>AGA	p.R515R	SRRM2_uc002crj.1_Silent_p.R419R|SRRM2_uc002crl.1_Silent_p.R515R|SRRM2_uc010bsu.1_Silent_p.R419R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	515	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGTGGCGTAGGTCCAGGTCTG	0.617													A	2812074	A	A	2812074	2	1	151	1	0	0	0	0	0	0	0	1	15168	1252	44	3		3	SRRM2	16	2812074	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08		2812074	87542679	79	10470											
ACSM2A	123876	broad.mit.edu	37	chr16	20476938	20476938	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagtgaaaacagccagcagGcagccaacgtcctctcggga	12	12	1	2	rs141326932		TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr16:20476938G>A	uc010bwe.2	+	4	516	c.277G>A	c.(277-279)GCA>ACA	p.A93T	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.A14T|ACSM2A_uc002dhf.3_Missense_Mutation_p.A93T|ACSM2A_uc002dhg.3_Missense_Mutation_p.A93T|ACSM2A_uc010vay.1_Missense_Mutation_p.A14T	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	93					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CAGCCAGCAGGCAGCCAACGT	0.612													A	20476938	A	A	20476938	3	1	151	1	0	0	0	0	1	0	0	0	183	1203	42	3	283	3	ACSM2A	16	20476938	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	17664864	20476938	69877815	80	10471											
ACSM2B	348158	broad.mit.edu	37	chr16	20570670	20570670	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccgagaggatgttggctgCctgctggctgttttcactca	12	11	2	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr16:20570670C>T	uc002dhj.3	-	4	487	c.277G>A	c.(277-279)GCA>ACA	p.A93T	ACSM2B_uc002dhk.3_Missense_Mutation_p.A93T|ACSM2B_uc010bwf.1_Missense_Mutation_p.A93T	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	93					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						ATGTTGGCTGCCTGCTGGCTG	0.602													T	20570670	T	T	20570670	3	4	151	1	0	0	0	0	1	0	0	0	184	739	26	3	1504	3	ACSM2B	16	20570670	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	93732	20570670	69784083	81	10472											
ALOX12B	242	broad.mit.edu	37	chr17	7989533	7989533	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggcactgcacggtgtactgGcccacctaggcaggatgcaa	14	12	0	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr17:7989533G>T	uc002gjy.1	-	2	414	c.153C>A	c.(151-153)GGC>GGA	p.G51G	hsa-mir-4314|MI0015846_5'Flank	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	51	PLAT.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						CGGTGTACTGGCCCACCTAGG	0.647										Multiple Myeloma(8;0.094)			T	7989533	T	T	7989533	2	4	151	1	0	0	0	0	0	0	0	1	537	1190	42	5		5	ALOX12B	17	7989533	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08		7989533	73205677	82	10473											
SMCR7	125170	broad.mit.edu	37	chr17	18167942	18167942	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccctggagctgctcatcgGcagcctggagcaggccagcc	14	15	1	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr17:18167942G>A	uc002gst.2	+	4	1440	c.1229G>A	c.(1228-1230)GGC>GAC	p.G410D	SMCR7_uc002gsu.2_3'UTR|SMCR7_uc010vxq.1_Missense_Mutation_p.G421D	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	410						integral to membrane	protein binding				0	all_neural(463;0.228)					CTGCTCATCGGCAGCCTGGAG	0.627													A	18167942	A	A	18167942	3	1	151	1	0	0	0	0	1	0	0	0	14790	1203	42	3	1276	3	SMCR7	17	18167942	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	10178409	18167942	63027268	83	10474											
GPR179	440435	broad.mit.edu	37	chr17	36499092	36499092	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgcttcttcagggcagggGtgtccaggtccccaggaggg	16	12	2	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr17:36499092G>A	uc002hpz.2	-	1	602	c.581C>T	c.(580-582)ACC>ATC	p.T194I		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	194	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CAGGGCAGGGGTGTCCAGGTC	0.642													A	36499092	A	A	36499092	3	1	151	1	0	0	0	0	1	0	0	0	6674	1261	44	3	6566	3	GPR179	17	36499092	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	18331150	36499092	44696118	84	10475											
PPM1D	8493	broad.mit.edu	37	chr17	58740521	58740521	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aagatccagaaccacttgaaGaaaattgcgctaaagccctg	8	10	0	4			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr17:58740521G>T	uc002iyt.1	+	6	1648	c.1426G>T	c.(1426-1428)GAA>TAA	p.E476*	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	476					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			ACCACTTGAAGAAAATTGCGC	0.403											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	T	58740521	T	T	58740521	4	4	151	1	0	0	0	0	0	1	0	0	12337	943	33	5	1448	5	PPM1D	17	58740521	Nonsense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	22241429	58740521	22454689	85	10476											
C17orf77	146723	broad.mit.edu	37	chr17	72588368	72588368	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtctcctctcctctccttggTgatcacaggtgtctggtgcc	10	14	5	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr17:72588368T>G	uc002jla.1	+	3	545	c.183T>G	c.(181-183)GGT>GGG	p.G61G	CD300LD_uc002jkz.2_5'UTR	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	61						extracellular region					0						CTCTCCTTGGTGATCACAGGT	0.537													G	72588368	G	G	72588368	2	3	151	1	0	0	0	0	0	0	0	1	1882	1683	59	5		5	C17orf77	17	72588368	Silent	SNP	T	TCGA-16-1048-01B-01D-1353-08	13847847	72588368	8606842	86	10477											
EMILIN2	84034	broad.mit.edu	37	chr18	2892201	2892201	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgcttgtaaggaatgcacGcagggggtccagagggaggt	18	6	0	1	rs3810066	by1000genomes	TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr18:2892201G>A	uc002kln.2	+	4	2235	c.2076G>A	c.(2074-2076)ACG>ACA	p.T692T		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	692					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		AGGAATGCACGCAGGGGGTCC	0.572													A	2892201	A	A	2892201	2	1	151	1	0	0	0	0	0	0	0	1	5094	1074	38	1		1	EMILIN2	18	2892201	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08		2892201	75185047	87	10478											
DCC	1630	broad.mit.edu	37	chr18	50592528	50592528	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagtgcacagctcattgtccCtaagcctggtaagacaatgg	10	11	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr18:50592528C>A	uc002lfe.1	+	7	1840	c.1253C>A	c.(1252-1254)CCT>CAT	p.P418H	DCC_uc010xdr.1_Missense_Mutation_p.P266H|DCC_uc010dpf.1_Missense_Mutation_p.P73H	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	418	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTCATTGTCCCTAAGCCTGGT	0.438													A	50592528	A	A	50592528	3	1	151	1	0	0	0	0	1	0	0	0	4282	681	24	5	1279	5	DCC	18	50592528	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	47700327	50592528	27484720	88	10479											
ZNF532	55205	broad.mit.edu	37	chr18	56587377	56587377	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgcgtgggtacaagtgcttgGagtgtggggactcctttgca	16	8	0	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr18:56587377G>T	uc002lho.2	+	4	2405	c.1858G>T	c.(1858-1860)GAG>TAG	p.E620*	ZNF532_uc002lhp.2_Nonsense_Mutation_p.E618*|ZNF532_uc010xeg.1_Nonsense_Mutation_p.E618*|ZNF532_uc002lhr.2_Nonsense_Mutation_p.E618*|ZNF532_uc002lhs.2_Nonsense_Mutation_p.E618*	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	620	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						CAAGTGCTTGGAGTGTGGGGA	0.537													T	56587377	T	T	56587377	4	4	151	1	0	0	0	0	0	1	0	0	17969	1175	41	5	1860	5	ZNF532	18	56587377	Nonsense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	5994849	56587377	21489871	89	10480											
MC4R	4160	broad.mit.edu	37	chr18	58039346	58039346	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagctgcagatgaaaaagtaCatgggtgaatgcagattctt	11	5	1	4			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr18:58039346C>T	uc002lie.1	-	1	656	c.237G>A	c.(235-237)ATG>ATA	p.M79I		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	79	Cytoplasmic (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				TGAAAAAGTACATGGGTGAAT	0.438													T	58039346	T	T	58039346	3	4	151	1	0	0	0	0	1	0	0	0	9366	478	17	3	765	3	MC4R	18	58039346	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	1451969	58039346	20037902	90	10481											
ARID3A	1820	broad.mit.edu	37	chr19	964263	964263	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccagggacacctgtgaaccGcatccccatcatggccaaac	8	17	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr19:964263G>A	uc002lql.2	+	5	1072	c.782G>A	c.(781-783)CGC>CAC	p.R261H		NM_005224	NP_005215	Q99856	ARI3A_HUMAN	AT rich interactive domain 3A (BRIGHT- like)	261	ARID.					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGTGAACCGCATCCCCATC	0.418													A	964263	A	A	964263	3	1	151	1	0	0	0	0	1	0	0	0	916	1087	38	1	796	1	ARID3A	19	964263	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08		964263	58164720	91	10482											
FUT6	2528	broad.mit.edu	37	chr19	5832254	5832254	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gttgtacatgacctctcggtGgtgcacgatgaccgcgtctg	13	11	2	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr19:5832254G>C	uc002mdf.1	-	4	851	c.325C>G	c.(325-327)CAC>GAC	p.H109D	FUT6_uc002mdg.1_Missense_Mutation_p.H109D|FUT6_uc002mdh.1_Missense_Mutation_p.H109D|FUT6_uc010dul.1_Missense_Mutation_p.H109D	NM_001040701	NP_001035791	P51993	FUT6_HUMAN	fucosyltransferase 6	109	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						ACCTCTCGGTGGTGCACGATG	0.642													C	5832254	C	C	5832254	3	2	151	1	0	0	0	0	1	0	0	0	6108	1348	47	5	758	5	FUT6	19	5832254	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	4867991	5832254	53296729	92	10483											
CYP2B6	1555	broad.mit.edu	37	chr19	41515999	41515999	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccaccagcaccactctccGctacggcttcctgctcatgc	7	19	2	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr19:41515999G>A	uc002opr.1	+	6	930	c.923G>A	c.(922-924)CGC>CAC	p.R308H	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	308					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	ACCACTCTCCGCTACGGCTTC	0.552													A	41515999	A	A	41515999	3	1	151	1	0	0	0	0	1	0	0	0	4164	1087	38	1	945	1	CYP2B6	19	41515999	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	35683745	41515999	17612984	93	10484											
FOXA3	3171	broad.mit.edu	37	chr19	46375889	46375889	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatggctgctacctgcgccGccagaaacgcttcaagctgg	12	13	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr19:46375889G>A	uc002pdr.2	+	2	823	c.626G>A	c.(625-627)CGC>CAC	p.R209H		NM_004497	NP_004488	P55318	FOXA3_HUMAN	forkhead box A3	209					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)	1		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		TACCTGCGCCGCCAGAAACGC	0.627													A	46375889	A	A	46375889	3	1	151	1	0	0	0	0	1	0	0	0	5991	1087	38	1	632	1	FOXA3	19	46375889	Missense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	4859890	46375889	12753094	94	10485											
ANGPT4	51378	broad.mit.edu	37	chr20	869018	869018	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtagcagcagctggttctccAgcttgttggtggacagaaag	14	8	1	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr20:869018A>G	uc002wei.2	-	3	633	c.530T>C	c.(529-531)CTG>CCG	p.L177P	ANGPT4_uc010zpn.1_Missense_Mutation_p.L171P	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	177	Potential.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						CTGGTTCTCCAGCTTGTTGGT	0.522													G	869018	G	G	869018	3	3	151	1	0	0	0	0	1	0	0	0	612	188	7	4	1009	4	ANGPT4	20	869018	Missense_Mutation	SNP	A	TCGA-16-1048-01B-01D-1353-08		869018	62156502	95	10486											
DHX35	60625	broad.mit.edu	37	chr20	37632428	37632428	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttgtgtcgatgctcatcgagCaggctcgagcactagctcgc	12	12	1	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr20:37632428C>A	uc002xjh.2	+	11	900	c.889C>A	c.(889-891)CAG>AAG	p.Q297K	DHX35_uc010zwa.1_Missense_Mutation_p.Q142K|DHX35_uc010zwb.1_Missense_Mutation_p.Q142K|DHX35_uc010zwc.1_Missense_Mutation_p.Q266K	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	297	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GCTCATCGAGCAGGCTCGAGC	0.453													A	37632428	A	A	37632428	3	1	151	1	0	0	0	0	1	0	0	0	4508	711	25	5	931	5	DHX35	20	37632428	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08	36763410	37632428	25393092	96	10487											
BACH1	571	broad.mit.edu	37	chr21	30693606	30693606	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	acatttgttatgcagaatgtCtctgagtgagaactcggttt	10	6	1	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr21:30693606C>G	uc002ynj.2	+	2	120	c.5C>G	c.(4-6)TCT>TGT	p.S2C	BACH1_uc002ynk.2_Missense_Mutation_p.S2C|BACH1_uc002ynl.2_RNA	NM_001186	NP_001177	O14867	BACH1_HUMAN	BTB and CNC homology 1 transcription factor	2						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|liver(1)	2						TGCAGAATGTCTCTGAGTGAG	0.403													G	30693606	G	G	30693606	3	3	151	1	0	0	0	0	1	0	0	0	1283	913	32	5	7	5	BACH1	21	30693606	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08		30693606	17436289	97	10488											
KRTAP12-3	386683	broad.mit.edu	37	chr21	46078019	46078019	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcatgcccgtgagctgcacGcgcattgtgtgcgtggctcc	14	13	0	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr21:46078019G>A	uc002zft.2	+	1	171	c.123G>A	c.(121-123)ACG>ACA	p.T41T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198697	NP_941970	P60328	KR123_HUMAN	keratin associated protein 12-3	41	14 X 5 AA approximate repeats.					intermediate filament				central_nervous_system(1)	1						TGAGCTGCACGCGCATTGTGT	0.637													A	46078019	A	A	46078019	2	1	151	1	0	0	0	0	0	0	0	1	8520	1074	38	1		1	KRTAP12-3	21	46078019	Silent	SNP	G	TCGA-16-1048-01B-01D-1353-08	15384413	46078019	2051876	98	10489											
PARVG	64098	broad.mit.edu	37	chr22	44581720	44581720	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatacctgccacccacttccCggaaggaccccaaatttgaa	6	15	0	1			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chr22:44581720C>T	uc011aqe.1	+	4	536	c.112C>T	c.(112-114)CGG>TGG	p.R38W	PARVG_uc010gzo.2_Missense_Mutation_p.R105W|PARVG_uc010gzp.2_RNA|PARVG_uc003bep.2_Missense_Mutation_p.R38W|PARVG_uc010gzq.1_RNA|PARVG_uc010gzr.1_RNA|PARVG_uc011aqf.1_Missense_Mutation_p.R38W|PARVG_uc003beq.2_RNA|PARVG_uc003ber.2_RNA	NM_001137605	NP_001131077	Q9HBI0	PARVG_HUMAN	parvin, gamma	38					cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding				0		Ovarian(80;0.024)|all_neural(38;0.0299)				ACCCACTTCCCGGAAGGACCC	0.607													T	44581720	T	T	44581720	3	4	151	1	0	0	0	0	1	0	0	0	11470	643	23	2	118	2	PARVG	22	44581720	Missense_Mutation	SNP	C	TCGA-16-1048-01B-01D-1353-08		44581720	6722846	99	10490											
PHF8	23133	broad.mit.edu	37	chrX	53970579	53970579	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacctacctgctgggccagCtttgcagctgctgcagccaa	11	15	0	0			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chrX:53970579C>T	uc004dsu.2	-	20	2818	c.2745G>A	c.(2743-2745)AAG>AAA	p.K915K	PHF8_uc004dst.2_Silent_p.K879K|PHF8_uc004dsv.2_Silent_p.K745K|PHF8_uc004dsw.2_Silent_p.K778K|PHF8_uc004dsx.2_Silent_p.K643K|PHF8_uc004dsy.2_Silent_p.K862K	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	915					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						GCTGGGCCAGCTTTGCAGCTG	0.592													T	53970579	T	T	53970579	2	4	151	1	0	0	0	0	0	0	0	1	11840	796	28	3		3	PHF8	23	53970579	Silent	SNP	C	TCGA-16-1048-01B-01D-1353-08		53970579	101299981	100	10491											
ITIH5L	347365	broad.mit.edu	37	chrX	54784130	54784130	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatgtgagtgccccaagttGggggtgcgatggagcaccag	17	8	0	2			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chrX:54784130G>A	uc004dtj.2	-	8	2407	c.2377C>T	c.(2377-2379)CAA>TAA	p.Q793*		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	793	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GCCCCAAGTTGGGGGTGCGAT	0.552													A	54784130	A	A	54784130	4	1	151	1	0	0	0	0	0	1	0	0	7908	1357	47	3	1588	3	ITIH5L	23	54784130	Nonsense_Mutation	SNP	G	TCGA-16-1048-01B-01D-1353-08	813551	54784130	100486430	101	10492											
PCDH11Y	83259	broad.mit.edu	37	chrY	4966471	4966471	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacccagtctttaaggagacAgagattgaagtcagtatacc	9	9	2	3			TCGA-16-1048-01B-01D-1353-08	TCGA-16-1048-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	52671a3d-7840-402c-a49c-8b9a6fb2674d	ece35cba-afac-4d82-8f6d-dd626efa0acf	g.chrY:4966471A>G	uc004fqo.2	+	2	1586	c.852A>G	c.(850-852)ACA>ACG	p.T284T	PCDH11Y_uc010nwg.1_Silent_p.T273T|PCDH11Y_uc004fql.1_Silent_p.T273T|PCDH11Y_uc004fqm.1_Silent_p.T273T|PCDH11Y_uc004fqn.1_Silent_p.T284T|PCDH11Y_uc004fqp.1_Silent_p.T55T	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	284	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TTAAGGAGACAGAGATTGAAG	0.428													G	4966471	G	G	4966471	2	3	151	1	0	0	0	0	0	0	0	1	11509	175	7	4		4	PCDH11Y	24	4966471	Silent	SNP	A	TCGA-16-1048-01B-01D-1353-08		4966471	54407095	102	10493											
EPHA10	284656	broad.mit.edu	37	chr1	38227511	38227511	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcctaggcggggacgcccaCggcccaggtcggcctcagtt	15	16	1	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:38227511C>T	uc009vvi.2	-	3	502	c.416G>A	c.(415-417)CGT>CAT	p.R139H	EPHA10_uc001cbw.3_Missense_Mutation_p.R139H	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	139	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGGACGCCCACGGCCCAGGTC	0.657													T	38227511	T	T	38227511	3	4	152	1	0	0	0	0	1	0	0	0	5166	536	19	1	2708	1	EPHA10	1	38227511	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		38227511	211023110	1	10494											
KIAA0467	23334	broad.mit.edu	37	chr1	43905598	43905598	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttggatgtgtgggaaaagggGaacattagtattgtgcagct	15	3	0	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:43905598G>A	uc001cjk.1	+	36	4854	c.4392G>A	c.(4390-4392)GGG>GGA	p.G1464G		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2363						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGGAAAAGGGGAACATTAGTA	0.567													A	43905598	A	A	43905598	2	1	152	1	0	0	0	0	0	0	0	1	8178	1161	41	3		3	KIAA0467	1	43905598	Silent	SNP	G	TCGA-19-1390-01A-01D-1495-08	5678087	43905598	205345023	2	10495											
DAB1	1600	broad.mit.edu	37	chr1	57535099	57535099	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcctcaaacacaatgtaCtattacaggagcagccagaa	7	12	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:57535099C>T	uc001cys.1	-	10	1272	c.598_splice	c.e10-1	p.Y200_splice	DAB1_uc001cyt.1_Splice_Site_p.Y200_splice|DAB1_uc001cyq.1_Intron|DAB1_uc001cyr.1_Intron|DAB1_uc009vzw.1_Intron|DAB1_uc009vzx.1_Splice_Site_p.Y200_splice	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1						cell differentiation|nervous system development					skin(2)|ovary(1)	3						ACACAATGTACTATTACAGGA	0.413													T	57535099	T	T	57535099	5	4	152	1	0	0	0	0	0	0	1	0	4217	579	20	3	1098	3	DAB1	1	57535099	Splice_Site	SNP	C	TCGA-19-1390-01A-01D-1495-08	13629501	57535099	191715522	3	10496											
TNNI3K	51086	broad.mit.edu	37	chr1	74665467	74665467	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaaaagaaaggagttacccCttggagttcaatatcacgtt	9	7	2	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:74665467C>T	uc001dge.1	+	2	218	c.202C>T	c.(202-204)CTT>TTT	p.L68F	LRRIQ3_uc001dfy.3_5'Flank|LRRIQ3_uc001dfz.3_5'Flank|TNNI3K_uc001dgc.1_Missense_Mutation_p.L68F|TNNI3K_uc001dgd.2_Missense_Mutation_p.L68F|FPGT_uc010oqt.1_5'UTR|FPGT_uc010oqu.1_Missense_Mutation_p.L68F|FPGT_uc001dgb.1_Missense_Mutation_p.L68F|FPGT_uc010oqv.1_Missense_Mutation_p.L68F	NM_001112808	NP_001106279	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform a	Error:Variant_position_missing_in_Q59H18_after_alignment						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						GGAGTTACCCCTTGGAGTTCA	0.403													T	74665467	T	T	74665467	3	4	152	1	0	0	0	0	1	0	0	0	16326	681	24	3	208	3	TNNI3K	1	74665467	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	17130368	74665467	174585154	4	10497											
ST6GALNAC3	256435	broad.mit.edu	37	chr1	76877752	76877752	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactcaggtcagatggttggCcagaaggtgggaaatgagat	15	5	2	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:76877752C>T	uc001dhh.2	+	3	436	c.273C>T	c.(271-273)GGC>GGT	p.G91G	ST6GALNAC3_uc001dhg.3_Silent_p.G91G|ST6GALNAC3_uc010orh.1_Silent_p.G26G	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	91	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						AGATGGTTGGCCAGAAGGTGG	0.448													T	76877752	T	T	76877752	2	4	152	1	0	0	0	0	0	0	0	1	15224	726	26	3		3	ST6GALNAC3	1	76877752	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	2212285	76877752	172372869	5	10498											
PDE4DIP	9659	broad.mit.edu	37	chr1	144854614	144854614	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtcgctcctgtttggataCtttggttctcagttccagaa	10	9	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:144854614C>T	uc001elw.3	-	42	7147	c.6856G>A	c.(6856-6858)GTA>ATA	p.V2286I	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.V2180I|PDE4DIP_uc001elv.3_Missense_Mutation_p.V1293I	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2286	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGTTTGGATACTTTGGTTCTC	0.498			T	PDGFRB	MPD								T	144854614	T	T	144854614	3	4	152	1	0	0	0	0	1	0	0	0	11643	565	20	3	196	3	PDE4DIP	1	144854614	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	67976862	144854614	104396007	6	10499											
LCE1E	353135	broad.mit.edu	37	chr1	152760044	152760044	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caggtcccaccgtcacagacCccagagctctgactgctgca	9	17	2	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:152760044C>A	uc001fan.2	+	2	322	c.269C>A	c.(268-270)CCC>CAC	p.P90H		NM_178353	NP_848130	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	90	Cys-rich.				keratinization						0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTCACAGACCCCAGAGCTCT	0.687													A	152760044	A	A	152760044	3	1	152	1	0	0	0	0	1	0	0	0	8663	623	22	5	271	5	LCE1E	1	152760044	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	7905430	152760044	96490577	7	10500											
RGS4	5999	broad.mit.edu	37	chr1	163044110	163044110	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccttggcctttgcccctcaGgtgaacctggattcttgcac	10	14	2	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:163044110G>A	uc009wuy.2	+	5	890	c.379_splice	c.e5-1	p.V127_splice	RGS4_uc001gcl.3_Splice_Site_p.V224_splice|RGS4_uc009wuz.2_Splice_Site_p.C71_splice|RGS4_uc009wva.2_Splice_Site_p.V109_splice	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2						inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						TTGCCCCTCAGGTGAACCTGG	0.488													A	163044110	A	A	163044110	5	1	152	1	0	0	0	0	0	0	1	0	13307	1014	35	3	691	3	RGS4	1	163044110	Splice_Site	SNP	G	TCGA-19-1390-01A-01D-1495-08	10284066	163044110	86206511	8	10501											
C1orf129	80133	broad.mit.edu	37	chr1	170928687	170928687	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctagttgtcatgccaagtctTgacaaagtaaaagaaatggg	10	6	2	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:170928687T>G	uc001ghg.2	+	5	367	c.237T>G	c.(235-237)CTT>CTG	p.L79L	C1orf129_uc009wvy.2_5'UTR|C1orf129_uc010plz.1_Silent_p.L79L	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	79							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGCCAAGTCTTGACAAAGTAA	0.363													G	170928687	G	G	170928687	2	3	152	1	0	0	0	0	0	0	0	1	1996	1799	63	5		5	C1orf129	1	170928687	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	7884577	170928687	78321934	9	10502											
CACNA1E	777	broad.mit.edu	37	chr1	181693656	181693656	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtggataatctcgccaacGcccaggaactgaccaaggta	10	12	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:181693656G>A	uc001gow.2	+	17	2290	c.2125G>A	c.(2125-2127)GCC>ACC	p.A709T	CACNA1E_uc009wxs.2_Missense_Mutation_p.A616T	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	709	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCTCGCCAACGCCCAGGAACT	0.463													A	181693656	A	A	181693656	3	1	152	1	0	0	0	0	1	0	0	0	2542	1087	38	1	2191	1	CACNA1E	1	181693656	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	10764969	181693656	67556965	10	10503											
C4BPA	722	broad.mit.edu	37	chr1	207300203	207300203	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtaattcattgtgatgctgaTagcaaatggaatccttctcc	8	8	2	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:207300203T>C	uc001hfo.2	+	7	1046	c.852T>C	c.(850-852)GAT>GAC	p.D284D		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	284	Sushi 4.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						GTGATGCTGATAGCAAATGGA	0.403													C	207300203	C	C	207300203	2	2	152	1	0	0	0	0	0	0	0	1	2249	1403	49	4		4	C4BPA	1	207300203	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	25606547	207300203	41950418	11	10504											
PARP1	142	broad.mit.edu	37	chr1	226550806	226550806	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaaacactttacctttgaCactgtgcttgcccttgggta	9	10	0	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:226550806C>T	uc001hqd.3	-	21	3013	c.2842G>A	c.(2842-2844)GTC>ATC	p.V948I		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	948	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TTACCTTTGACACTGTGCTTG	0.527								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					T	226550806	T	T	226550806	3	4	152	1	0	0	0	0	1	0	0	0	11454	478	17	3	214	3	PARP1	1	226550806	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	19250603	226550806	22699815	12	10505											
RYR2	6262	broad.mit.edu	37	chr1	237789020	237789020	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgatttaacaattagagggCgtctgctatccctggtagaa	11	7	1	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:237789020C>T	uc001hyl.1	+	40	6202	c.6082C>T	c.(6082-6084)CGT>TGT	p.R2028C		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2028	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AATTAGAGGGCGTCTGCTATC	0.393													T	237789020	T	T	237789020	3	4	152	1	0	0	0	0	1	0	0	0	13769	768	27	1	6240	1	RYR2	1	237789020	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	11238214	237789020	11461601	13	10506											
OR2T27	403239	broad.mit.edu	37	chr1	248814164	248814164	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggataaagtcggcatacaCggaataattgctctgctcca	9	9	1	0	rs144642254		TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr1:248814164C>T	uc010pzo.1	-	1	22	c.22G>A	c.(22-24)GTG>ATG	p.V8M		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCGGCATACACGGAATAATTG	0.433													T	248814164	T	T	248814164	3	4	152	1	0	0	0	0	1	0	0	0	11021	536	19	1	934	1	OR2T27	1	248814164	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	11025144	248814164	436457	14	10507											
NCOA1	8648	broad.mit.edu	37	chr2	24929877	24929877	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcctttcctcctaatatttCgacattaagctctcccgttg	4	13	1	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:24929877C>T	uc002rfk.2	+	11	1796	c.1538C>T	c.(1537-1539)TCG>TTG	p.S513L	NCOA1_uc010eye.2_Missense_Mutation_p.S513L|NCOA1_uc002rfi.2_Missense_Mutation_p.S362L|NCOA1_uc002rfj.2_Missense_Mutation_p.S513L|NCOA1_uc002rfl.2_Missense_Mutation_p.S513L	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	513	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTAATATTTCGACATTAAGC	0.418			T	PAX3	alveolar rhadomyosarcoma								T	24929877	T	T	24929877	3	4	152	1	0	0	0	0	1	0	0	0	10228	893	31	2	1572	2	NCOA1	2	24929877	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		24929877	218269496	15	10508											
FAM179A	165186	broad.mit.edu	37	chr2	29268218	29268218	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgccttctaccagcgcttgcTgggcgagtgcgtttcctgag	13	12	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:29268218T>A	uc010ezl.2	+	19	3015	c.2664T>A	c.(2662-2664)GCT>GCA	p.A888A	FAM179A_uc010ymm.1_Silent_p.A833A|FAM179A_uc002rmr.3_Silent_p.A415A|FAM179A_uc002rms.1_Silent_p.A186A	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	888							binding			ovary(3)|skin(1)	4						CAGCGCTTGCTGGGCGAGTGC	0.627													A	29268218	A	A	29268218	2	1	152	1	0	0	0	0	0	0	0	1	5505	1567	55	5		5	FAM179A	2	29268218	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	4338341	29268218	213931155	16	10509											
CYP1B1	1545	broad.mit.edu	37	chr2	38302345	38302345	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcctggcccaccgccgccgCgtttccgatcagtggccacg	12	19	1	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:38302345C>T	uc002rqo.2	-	3	590	c.187G>A	c.(187-189)GCG>ACG	p.A63T		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	63					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	ACCGCCGCCGCGTTTCCGATC	0.721													T	38302345	T	T	38302345	3	4	152	1	0	0	0	0	1	0	0	0	4151	768	27	1	1452	1	CYP1B1	2	38302345	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	9034127	38302345	204897028	17	10510											
ALMS1	7840	broad.mit.edu	37	chr2	73651879	73651879	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggcctgaaaacaatttagcTgataaagatcaagtttcagt	8	6	2	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:73651879T>A	uc002sje.1	+	6	1200	c.1089T>A	c.(1087-1089)GCT>GCA	p.A363A	ALMS1_uc002sjf.1_Silent_p.A320A	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	362					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						ACAATTTAGCTGATAAAGATC	0.358													A	73651879	A	A	73651879	2	1	152	1	0	0	0	0	0	0	0	1	535	1567	55	5		5	ALMS1	2	73651879	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	35349534	73651879	169547494	18	10511											
DQX1	165545	broad.mit.edu	37	chr2	74747143	74747143	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctgcactgagtggaggaCgggtaaacccaggggcagct	15	10	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:74747143C>T	uc010yrw.1	-	9	1679	c.1514G>A	c.(1513-1515)CGT>CAT	p.R505H	DQX1_uc002smc.2_Missense_Mutation_p.R66H	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	505						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						GAGTGGAGGACGGGTAAACCC	0.527													T	74747143	T	T	74747143	3	4	152	1	0	0	0	0	1	0	0	0	4751	536	19	1	655	1	DQX1	2	74747143	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	1095264	74747143	168452230	19	10512											
MRPL30	51263	broad.mit.edu	37	chr2	99811636	99811636	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgaatgcaaaattgaaagtaGttaagcatttgataaggttt	9	2	0	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:99811636G>C	uc002szu.2	+	5	499	c.337G>C	c.(337-339)GTT>CTT	p.V113L	MRPL30_uc002szl.1_RNA|MRPL30_uc002szr.2_Missense_Mutation_p.V113L|MRPL30_uc002szt.1_RNA|MRPL30_uc002szv.2_Missense_Mutation_p.V113L	NM_145213	NP_660214	Q8TCC3	RM30_HUMAN	RecName: Full=39S ribosomal protein L30, mitochondrial;          Short=L30mt; AltName: Full=MRP-L30; AltName: Full=MRP-L28; Flags: Precursor;	113					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1						ATTGAAAGTAGTTAAGCATTT	0.333													C	99811636	C	C	99811636	3	2	152	1	0	0	0	0	1	0	0	0	9794	1029	36	5	351	5	MRPL30	2	99811636	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	25064493	99811636	143387737	20	10513											
IL1F6	27179	broad.mit.edu	37	chr2	113763644	113763644	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgctcatagcagtcccgaGgaaggaccgtatgtctccag	12	12	2	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:113763644G>A	uc010yxr.1	+	2	104	c.104G>A	c.(103-105)AGG>AAG	p.R35K		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	35					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding				0						GCAGTCCCGAGGAAGGACCGT	0.512													A	113763644	A	A	113763644	3	1	152	1	0	0	0	0	1	0	0	0	7654	1000	35	3	110	3	IL1F6	2	113763644	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	13952008	113763644	129435729	21	10514											
THSD7B	80731	broad.mit.edu	37	chr2	138420998	138420998	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctatacagagataatgaaaTcaaatggtttcctggattac	8	6	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:138420998T>C	uc002tva.1	+	25	4417	c.4417T>C	c.(4417-4419)TCA>CCA	p.S1473P	THSD7B_uc010zbj.1_RNA	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GATAATGAAATCAAATGGTTT	0.383													C	138420998	C	C	138420998	3	2	152	1	0	0	0	0	1	0	0	0	15877	1435	50	4	4514	4	THSD7B	2	138420998	Missense_Mutation	SNP	T	TCGA-19-1390-01A-01D-1495-08	24657354	138420998	104778375	22	10515											
XIRP2	129446	broad.mit.edu	37	chr2	168106391	168106391	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggaccatcaatgattggtcGaaaagaagagagattaataa	11	4	1	4			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:168106391G>A	uc002udx.2	+	8	8507	c.8489G>A	c.(8488-8490)CGA>CAA	p.R2830Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R2655Q|XIRP2_uc010fpq.2_Missense_Mutation_p.R2608Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.R176Q	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2655					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATGATTGGTCGAAAAGAAGAG	0.398													A	168106391	A	A	168106391	3	1	152	1	0	0	0	0	1	0	0	0	17427	1058	37	2	8519	2	XIRP2	2	168106391	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	29685393	168106391	75092982	23	10516											
TTN	7273	broad.mit.edu	37	chr2	179431720	179431720	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaagcacaaatggatttttcAttagtactggtgcagattcc	9	7	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:179431720A>G	uc010zfg.1	-	275	71659	c.71435T>C	c.(71434-71436)ATG>ACG	p.M23812T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.M17507T|TTN_uc010zfi.1_Missense_Mutation_p.M17440T|TTN_uc010zfj.1_Missense_Mutation_p.M17315T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24739							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGATTTTTCATTAGTACTGG	0.403													G	179431720	G	G	179431720	3	3	152	1	0	0	0	0	1	0	0	0	16732	217	8	4	28988	4	TTN	2	179431720	Missense_Mutation	SNP	A	TCGA-19-1390-01A-01D-1495-08	11325329	179431720	63767653	24	10517											
TTN	7273	broad.mit.edu	37	chr2	179456867	179456867	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagagaggtgaccactgggCgctggcaacatctctcctct	12	12	2	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:179456867C>T	uc010zfg.1	-	251	52284	c.52060G>A	c.(52060-52062)GCC>ACC	p.A17354T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A11049T|TTN_uc010zfi.1_Missense_Mutation_p.A10982T|TTN_uc010zfj.1_Missense_Mutation_p.A10857T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18281							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACCACTGGGCGCTGGCAACA	0.448													T	179456867	T	T	179456867	3	4	152	1	0	0	0	0	1	0	0	0	16732	768	27	1	48459	1	TTN	2	179456867	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	25147	179456867	63742506	25	10518											
SMARCAL1	50485	broad.mit.edu	37	chr2	217329391	217329391	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctaaaatcccatctgtcatGtaagtggtcactaagtgtcg	9	9	3	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr2:217329391G>A	uc002vgc.3	+	13	2471	c.2141_splice	c.e13+1	p.I714_splice	SMARCAL1_uc010fvf.2_Splice_Site|SMARCAL1_uc002vgd.3_Splice_Site_p.I714_splice|SMARCAL1_uc010fvg.2_Splice_Site_p.I692_splice	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated						chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CATCTGTCATGTAAGTGGTCA	0.363									Schimke_Immuno-Osseous_Dysplasia				A	217329391	A	A	217329391	5	1	152	1	0	0	0	0	0	0	1	0	14773	1391	48	3	2184	3	SMARCAL1	2	217329391	Splice_Site	SNP	G	TCGA-19-1390-01A-01D-1495-08	37872524	217329391	25869982	26	10519											
ALS2CL	259173	broad.mit.edu	37	chr3	46720751	46720751	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgccctcatacagggagtcGtcttcagagaggaggatgcc	14	10	3	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr3:46720751G>A	uc003cqa.1	-	15	1765	c.1575C>T	c.(1573-1575)GAC>GAT	p.D525D	ALS2CL_uc003cpx.1_5'Flank|ALS2CL_uc003cpy.1_5'Flank|ALS2CL_uc003cpz.1_Silent_p.D40D|ALS2CL_uc003cqb.1_Silent_p.D525D|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	525	MORN 7.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		ACAGGGAGTCGTCTTCAGAGA	0.627													A	46720751	A	A	46720751	2	1	152	1	0	0	0	0	0	0	0	1	551	1136	40	1		1	ALS2CL	3	46720751	Silent	SNP	G	TCGA-19-1390-01A-01D-1495-08		46720751	151301679	27	10520											
MORC1	27136	broad.mit.edu	37	chr3	108778663	108778663	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tgtgtcttacctttgtttctCtttaagattcttttgctttg	6	7	3	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr3:108778663C>A	uc003dxl.2	-	12	1108	c.1021G>T	c.(1021-1023)GAG>TAG	p.E341*	MORC1_uc011bhn.1_Nonsense_Mutation_p.E341*	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	341	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CTTTGTTTCTCTTTAAGATTC	0.368													A	108778663	A	A	108778663	4	1	152	1	0	0	0	0	0	1	0	0	9701	922	32	5	2001	5	MORC1	3	108778663	Nonsense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	62057912	108778663	89243767	28	10521											
GOLGB1	2804	broad.mit.edu	37	chr3	121410932	121410932	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttctaaaacaatattctcctCttcctcctgggacagcaggt	6	12	3	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr3:121410932C>T	uc003eei.3	-	14	7390	c.7264G>A	c.(7264-7266)GAG>AAG	p.E2422K	GOLGB1_uc010hrc.2_Missense_Mutation_p.E2427K|GOLGB1_uc003eej.3_Missense_Mutation_p.E2388K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2422	Cytoplasmic (Potential).|Potential.|Poly-Glu.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		ATATTCTCCTCTTCCTCCTGG	0.398													T	121410932	T	T	121410932	3	4	152	1	0	0	0	0	1	0	0	0	6565	922	32	3	2551	3	GOLGB1	3	121410932	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	12632269	121410932	76611498	29	10522											
CASR	846	broad.mit.edu	37	chr3	122004023	122004023	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagcactgttacagaaaaCgtagtgaattcataaaatgg	10	6	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr3:122004023C>T	uc003eev.3	+	7	3594	c.3222C>T	c.(3220-3222)AAC>AAT	p.N1074N	CASR_uc003eew.3_Silent_p.N1084N	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	1074	Cytoplasmic (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TTACAGAAAACGTAGTGAATT	0.522													T	122004023	T	T	122004023	2	4	152	1	0	0	0	0	0	0	0	1	2682	535	19	1		1	CASR	3	122004023	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	593091	122004023	76018407	30	10523											
TLR1	7096	broad.mit.edu	37	chr4	38798595	38798595	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgttcctggccctgcgccGggtctgggtccactggcaca	13	14	1	0	rs144775976	byFrequency	TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr4:38798595G>A	uc003gtl.2	-	4	2132	c.1858C>T	c.(1858-1860)CGG>TGG	p.R620W		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	620	Cytoplasmic (Potential).				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						GCCCTGCGCCGGGTCTGGGTC	0.517													A	38798595	A	A	38798595	3	1	152	1	0	0	0	0	1	0	0	0	15946	1115	39	2	506	2	TLR1	4	38798595	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08		38798595	152355681	31	10524											
PDGFRA	5156	broad.mit.edu	37	chr4	55138611	55138611	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcaccatggctcaactgggGgacagacggtgaggtgcaca	14	10	2	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr4:55138611G>A	uc003han.3	+	9	1619	c.1288G>A	c.(1288-1290)GGA>AGA	p.G430R	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.G324R|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	430	Ig-like C2-type 5.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTCAACTGGGGGACAGACGGT	0.473			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			A	55138611	A	A	55138611	3	1	152	1	0	0	0	0	1	0	0	0	11661	1233	43	3	1318	3	PDGFRA	4	55138611	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	16340016	55138611	136015665	32	10525											
PDGFRA	5156	broad.mit.edu	37	chr4	55138664	55138664	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ccgcttcctgatattgagtgGatgatatgcaaagatattaa	9	6	0	4			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr4:55138664G>C	uc003han.3	+	9	1672	c.1341G>C	c.(1339-1341)TGG>TGC	p.W447C	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.W341C|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	447	Ig-like C2-type 5.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	ATATTGAGTGGATGATATGCA	0.438			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			C	55138664	C	C	55138664	3	2	152	1	0	0	0	0	1	0	0	0	11661	1183	41	5	1371	5	PDGFRA	4	55138664	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	53	55138664	136015612	33	10526											
FRAS1	80144	broad.mit.edu	37	chr4	79418093	79418093	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	aagaataacatggccaccatCaccatatccaatgatgaaga	6	10	1	4			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr4:79418093C>A	uc003hlb.2	+	60	9533	c.9093C>A	c.(9091-9093)ATC>ATA	p.I3031I	FRAS1_uc003hlc.1_Silent_p.I33I	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3026	Calx-beta 5.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGGCCACCATCACCATATCCA	0.408													A	79418093	A	A	79418093	2	1	152	1	0	0	0	0	0	0	0	1	6042	816	29	5		5	FRAS1	4	79418093	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	24279429	79418093	111736183	34	10527											
LARP7	51574	broad.mit.edu	37	chr4	113568448	113568448	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catggacacaagcaacaccaGcatcagtaaaatgaaaagat	7	9	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr4:113568448G>A	uc003iay.2	+	7	1018	c.740G>A	c.(739-741)AGC>AAC	p.S247N	LARP7_uc003iaz.2_Missense_Mutation_p.S254N|LARP7_uc003iba.2_Missense_Mutation_p.S168N|LARP7_uc003ibb.2_Missense_Mutation_p.S247N	NM_016648	NP_057732	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	247	Lys-rich.				RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(3)	3		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		agcaacaCCAGCATCAGTAAA	0.234													A	113568448	A	A	113568448	3	1	152	1	0	0	0	0	1	0	0	0	8633	971	34	3	762	3	LARP7	4	113568448	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	34150355	113568448	77585828	35	10528											
ARFIP1	27236	broad.mit.edu	37	chr4	153809448	153809448	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctgtcaaattgaaatttctaGaagaaaataaggtaaattct	6	4	3	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr4:153809448G>A	uc003imz.2	+	8	1231	c.955G>A	c.(955-957)GAA>AAA	p.E319K	ARFIP1_uc003inb.2_Missense_Mutation_p.E287K|ARFIP1_uc003ina.2_Missense_Mutation_p.E287K|ARFIP1_uc003inc.2_Missense_Mutation_p.E319K|ARFIP1_uc011cij.1_Missense_Mutation_p.E139K	NM_001025595	NP_001020766	P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	319	AH.				intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane				ovary(1)	1	all_hematologic(180;0.093)					GAAATTTCTAGAAGAAAATAA	0.353													A	153809448	A	A	153809448	3	1	152	1	0	0	0	0	1	0	0	0	854	943	33	3	981	3	ARFIP1	4	153809448	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	40241000	153809448	37344828	36	10529											
ACCN5	51802	broad.mit.edu	37	chr4	156764950	156764950	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aagatgatcccagcatcaacGaaaccaagggctgggttatc	10	10	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr4:156764950G>A	uc003ipe.1	-	5	791	c.744C>T	c.(742-744)TTC>TTT	p.F248F		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	248	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		CAGCATCAACGAAACCAAGGG	0.413													A	156764950	A	A	156764950	2	1	152	1	0	0	0	0	0	0	0	1	132	1049	37	2		2	ACCN5	4	156764950	Silent	SNP	G	TCGA-19-1390-01A-01D-1495-08	2955502	156764950	34389326	37	10530											
FSTL5	56884	broad.mit.edu	37	chr4	162459448	162459448	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttatgtgaacctcactgccAtttgctgaaaaaagaaggga	9	8	1	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr4:162459448A>G	uc003iqh.2	-	10	1618	c.1182T>C	c.(1180-1182)AAT>AAC	p.N394N	FSTL5_uc003iqi.2_Silent_p.N393N|FSTL5_uc010iqv.2_Silent_p.N393N	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	394	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CCTCACTGCCATTTGCTGAAA	0.408													G	162459448	G	G	162459448	2	3	152	1	0	0	0	0	0	0	0	1	6080	214	8	4		4	FSTL5	4	162459448	Silent	SNP	A	TCGA-19-1390-01A-01D-1495-08	5694498	162459448	28694828	38	10531											
IRX2	153572	broad.mit.edu	37	chr5	2749779	2749779	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccttgagagtggccgtggcGtcccgcgtggcgttcttgcg	17	12	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr5:2749779G>A	uc003jda.2	-	2	614	c.372C>T	c.(370-372)GAC>GAT	p.D124D	C5orf38_uc003jdc.2_5'Flank|C5orf38_uc011cmg.1_5'Flank|C5orf38_uc011cmh.1_5'Flank|C5orf38_uc011cmi.1_5'Flank|C5orf38_uc011cmj.1_5'Flank|IRX2_uc003jdb.2_Silent_p.D124D	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	124	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		TGGCCGTGGCGTCCCGCGTGG	0.652													A	2749779	A	A	2749779	2	1	152	1	0	0	0	0	0	0	0	1	7844	1136	40	1		1	IRX2	5	2749779	Silent	SNP	G	TCGA-19-1390-01A-01D-1495-08		2749779	178165481	39	10532											
BDP1	55814	broad.mit.edu	37	chr5	70813215	70813215	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttccagaacacagaatgtatGaaaatcaaagtcaggtggtt	9	6	2	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr5:70813215G>A	uc003kbp.1	+	22	5190	c.4927G>A	c.(4927-4929)GAA>AAA	p.E1643K	BDP1_uc003kbo.2_Missense_Mutation_p.E1643K	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1643					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CAGAATGTATGAAAATCAAAG	0.303													A	70813215	A	A	70813215	3	1	152	1	0	0	0	0	1	0	0	0	1395	1291	45	3	5013	3	BDP1	5	70813215	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	68063436	70813215	110102045	40	10533											
JMY	133746	broad.mit.edu	37	chr5	78612055	78612055	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cggagcatccatgaagctctTagaagaattaaagaagcatc	9	8	1	4			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr5:78612055T>C	uc003kfx.3	+	10	3412	c.2892T>C	c.(2890-2892)CTT>CTC	p.L964L		NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	964					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		ATGAAGCTCTTAGAAGAATTA	0.438													C	78612055	C	C	78612055	2	2	152	1	0	0	0	0	0	0	0	1	7957	1741	61	4		4	JMY	5	78612055	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	7798840	78612055	102303205	41	10534											
HOMER1	9456	broad.mit.edu	37	chr5	78697771	78697771	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gataggcagcaagttgctgtTtccattgtttcacattggca	10	8	1	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr5:78697771T>C	uc003kfy.2	-	6	1738	c.635A>G	c.(634-636)AAA>AGA	p.K212R	HOMER1_uc010jab.2_Intron|HOMER1_uc010jac.2_Intron|HOMER1_uc010jad.2_Missense_Mutation_p.K38R	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	212	Potential.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		AAGTTGCTGTTTCCATTGTTT	0.478													C	78697771	C	C	78697771	3	2	152	1	0	0	0	0	1	0	0	0	7278	1841	64	4	445	4	HOMER1	5	78697771	Missense_Mutation	SNP	T	TCGA-19-1390-01A-01D-1495-08	85716	78697771	102217489	42	10535											
ELL2	22936	broad.mit.edu	37	chr5	95234136	95234136	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cataggctttggacactttaGtagaacggaaccagggggta	13	7	0	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr5:95234136G>T	uc003klr.3	-	8	1683	c.1333C>A	c.(1333-1335)CTA>ATA	p.L445I		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	445					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		GGACACTTTAGTAGAACGGAA	0.373													T	95234136	T	T	95234136	3	4	152	1	0	0	0	0	1	0	0	0	5063	1020	36	5	609	5	ELL2	5	95234136	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	16536365	95234136	85681124	43	10536											
APC	324	broad.mit.edu	37	chr5	112174282	112174282	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaagtaagttttgcagttaTggtcaatacccagccgacct	9	9	1	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr5:112174282T>C	uc010jby.2	+	16	3371	c.2991T>C	c.(2989-2991)TAT>TAC	p.Y997Y	APC_uc011cvt.1_Silent_p.Y979Y|APC_uc003kpz.3_Silent_p.Y997Y|APC_uc003kpy.3_Silent_p.Y997Y|APC_uc010jbz.2_Silent_p.Y714Y|APC_uc010jca.2_Silent_p.Y297Y	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	997	Ser-rich.|Responsible for down-regulation through a process mediated by direct ubiquitination.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.Y997fs*8(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TTTGCAGTTATGGTCAATACC	0.343		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			C	112174282	C	C	112174282	2	2	152	1	0	0	0	0	0	0	0	1	763	1471	51	4		4	APC	5	112174282	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	16940146	112174282	68740978	44	10537											
MAML1	9794	broad.mit.edu	37	chr5	179201677	179201677	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccctgcctcacagatgggCggtcgggcggggctgcactg	17	13	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr5:179201677C>T	uc003mkm.2	+	5	3113	c.2850C>T	c.(2848-2850)GGC>GGT	p.G950G	MAML1_uc003mkn.1_Intron	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	950					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACAGATGGGCGGTCGGGCGG	0.706													T	179201677	T	T	179201677	2	4	152	1	0	0	0	0	0	0	0	1	9205	755	27	1		1	MAML1	5	179201677	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	67027395	179201677	1713583	45	10538											
MYLK4	340156	broad.mit.edu	37	chr6	2685573	2685573	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gttcttagactcgaaggcatCgtacagctggatgaggttcg	13	8	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr6:2685573C>A	uc003mty.3	-	6	799	c.502G>T	c.(502-504)GAT>TAT	p.D168Y		NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	168	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				TCGAAGGCATCGTACAGCTGG	0.557													A	2685573	A	A	2685573	3	1	152	1	0	0	0	0	1	0	0	0	10059	884	31	5	692	5	MYLK4	6	2685573	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		2685573	168429494	46	10539											
HIVEP1	3096	broad.mit.edu	37	chr6	12164550	12164550	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaggcacattctgaagtTtttacaaagccctcaggcca	8	11	2	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr6:12164550T>C	uc003nac.2	+	9	8192	c.8013T>C	c.(8011-8013)GTT>GTC	p.V2671V	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2671					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ATTCTGAAGTTTTTACAAAGC	0.577													C	12164550	C	C	12164550	2	2	152	1	0	0	0	0	0	0	0	1	7186	1828	64	4		4	HIVEP1	6	12164550	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	9478977	12164550	158950517	47	10540											
RNF5	6048	broad.mit.edu	37	chr6	32147882	32147882	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ccaccgtcttcaatgcccatGagcctttccgccggggtaca	9	16	2	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr6:32147882G>A	uc003oaj.3	+	5	551	c.424G>A	c.(424-426)GAG>AAG	p.E142K	AGPAT1_uc003oaf.2_5'Flank|AGPAT1_uc003oag.2_5'Flank|AGPAT1_uc003oah.2_5'Flank	NM_006913	NP_008844	Q99942	RNF5_HUMAN	ring finger protein 5	142					ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						CAATGCCCATGAGCCTTTCCG	0.557													A	32147882	A	A	32147882	3	1	152	1	0	0	0	0	1	0	0	0	13497	1291	45	3	442	3	RNF5	6	32147882	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	19983332	32147882	138967185	48	10541											
COL11A2	1302	broad.mit.edu	37	chr6	33133402	33133402	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcctgggtccctgttggccgCctcatctgctcgatctcctc	9	17	3	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr6:33133402C>A	uc003ocx.1	-	63	4902	c.4674G>T	c.(4672-4674)AGG>AGT	p.R1558S	COL11A2_uc010jul.1_Missense_Mutation_p.R128S|COL11A2_uc003ocy.1_Missense_Mutation_p.R1472S|COL11A2_uc003ocz.1_Missense_Mutation_p.R1451S	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1558	Fibrillar collagen NC1.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CTGTTGGCCGCCTCATCTGCT	0.662													A	33133402	A	A	33133402	3	1	152	1	0	0	0	0	1	0	0	0	3668	738	26	5	552	5	COL11A2	6	33133402	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	985520	33133402	137981665	49	10542											
TFEB	7942	broad.mit.edu	37	chr6	41654875	41654875	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattcccaactccttgatgcGgtcattgatgttgaaccttc	7	12	1	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr6:41654875G>A	uc003oqs.1	-	8	1062	c.760C>T	c.(760-762)CGC>TGC	p.R254C	TFEB_uc003oqt.1_Missense_Mutation_p.R254C|TFEB_uc003oqu.1_Missense_Mutation_p.R268C|TFEB_uc003oqv.1_Missense_Mutation_p.R254C|TFEB_uc003oqr.1_Missense_Mutation_p.R169C	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	254	Helix-loop-helix motif.				embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TCCTTGATGCGGTCATTGATG	0.537			T	ALPHA	renal (childhood epithelioid)								A	41654875	A	A	41654875	3	1	152	1	0	0	0	0	1	0	0	0	15798	1116	39	2	682	2	TFEB	6	41654875	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	8521473	41654875	129460192	50	10543											
C7orf31	136895	broad.mit.edu	37	chr7	25182279	25182279	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgtaaaatcatgagtgtacGaagtgagccagtgggacctc	12	8	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr7:25182279G>A	uc003sxn.1	-	8	1400	c.839C>T	c.(838-840)TCG>TTG	p.S280L	C7orf31_uc003sxm.1_Missense_Mutation_p.S122L	NM_138811	NP_620166	Q8N865	CG031_HUMAN	hypothetical protein LOC136895	280											0						ATGAGTGTACGAAGTGAGCCA	0.368													A	25182279	A	A	25182279	3	1	152	1	0	0	0	0	1	0	0	0	2387	1059	37	2	945	2	C7orf31	7	25182279	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08		25182279	133956384	51	10544											
VPS41	27072	broad.mit.edu	37	chr7	38816326	38816326	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cgaaagtacaacaagctgatCacagagaggtgcaagtccac	10	10	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr7:38816326C>T	uc003tgy.2	-	11	861	c.835G>A	c.(835-837)GAT>AAT	p.D279N	VPS41_uc003tgz.2_Missense_Mutation_p.D254N|VPS41_uc010kxn.2_Missense_Mutation_p.D190N	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	279					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						ACAAGCTGATCACAGAGAGGT	0.413													T	38816326	T	T	38816326	3	4	152	1	0	0	0	0	1	0	0	0	17207	826	29	3	1805	3	VPS41	7	38816326	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	13634047	38816326	120322337	52	10545											
URGCP	55665	broad.mit.edu	37	chr7	43917540	43917540	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gagctggcagaactccttctCcacttgggctgcctttctcc	9	15	2	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr7:43917540C>T	uc003tiw.2	-	6	1579	c.1522G>A	c.(1522-1524)GAG>AAG	p.E508K	URGCP_uc003tiu.2_Missense_Mutation_p.E465K|URGCP_uc003tiv.2_Missense_Mutation_p.E433K|URGCP_uc003tix.2_Missense_Mutation_p.E499K|URGCP_uc003tiy.2_Missense_Mutation_p.E465K|URGCP_uc003tiz.2_Missense_Mutation_p.E465K|URGCP_uc011kbj.1_Missense_Mutation_p.E465K	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	508					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						AACTCCTTCTCCACTTGGGCT	0.607													T	43917540	T	T	43917540	3	4	152	1	0	0	0	0	1	0	0	0	17023	864	30	3	1277	3	URGCP	7	43917540	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	5101214	43917540	115221123	53	10546											
POM121L12	285877	broad.mit.edu	37	chr7	53103790	53103790	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggtgaccatcgggatcgcGccccctgagcgtcaggagag	15	14	1	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr7:53103790G>A	uc003tpz.2	+	1	442	c.426G>A	c.(424-426)GCG>GCA	p.A142A		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	142											0						TCGGGATCGCGCCCCCTGAGC	0.587													A	53103790	A	A	53103790	2	1	152	1	0	0	0	0	0	0	0	1	12241	1074	38	1		1	POM121L12	7	53103790	Silent	SNP	G	TCGA-19-1390-01A-01D-1495-08	9186250	53103790	106034873	54	10547											
POM121L12	285877	broad.mit.edu	37	chr7	53103915	53103915	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tctgctgggggcgctcagccAgtgccccaagggaagcgcta	15	13	2	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr7:53103915A>T	uc003tpz.2	+	1	567	c.551A>T	c.(550-552)CAG>CTG	p.Q184L		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	184											0						GCGCTCAGCCAGTGCCCCAAG	0.577													T	53103915	T	T	53103915	3	4	152	1	0	0	0	0	1	0	0	0	12241	188	7	5	553	5	POM121L12	7	53103915	Missense_Mutation	SNP	A	TCGA-19-1390-01A-01D-1495-08	125	53103915	106034748	55	10548											
DUS4L	11062	broad.mit.edu	37	chr7	107217955	107217955	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaagggtatttaatgctctgTcaagcacatcagcaatcata	7	8	4	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr7:107217955T>G	uc003veh.2	+	8	1237	c.904T>G	c.(904-906)TCA>GCA	p.S302A	DUS4L_uc003veg.2_Missense_Mutation_p.S181A|DUS4L_uc011klw.1_RNA|DUS4L_uc011klx.1_Missense_Mutation_p.S181A|DUS4L_uc010ljl.2_Missense_Mutation_p.S212A|BCAP29_uc003vej.2_5'Flank|BCAP29_uc011kly.1_5'Flank|BCAP29_uc011klz.1_5'Flank	NM_181581	NP_853559	O95620	DUS4L_HUMAN	dihydrouridine synthase 4-like	302					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0						TAATGCTCTGTCAAGCACATC	0.353													G	107217955	G	G	107217955	3	3	152	1	0	0	0	0	1	0	0	0	4808	1667	58	5	926	5	DUS4L	7	107217955	Missense_Mutation	SNP	T	TCGA-19-1390-01A-01D-1495-08	54114040	107217955	51920708	56	10549											
TES	26136	broad.mit.edu	37	chr7	115889257	115889257	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atattgacgaatccagttgcTgccaagaagaatgtctccat	8	9	1	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr7:115889257T>A	uc003vho.2	+	3	478	c.297T>A	c.(295-297)GCT>GCA	p.A99A	TES_uc011kmx.1_Silent_p.A99A|TES_uc011kmy.1_Intron|TES_uc010lka.1_Silent_p.A90A|TES_uc003vhp.2_Silent_p.A90A	NM_015641	NP_056456	Q9UGI8	TES_HUMAN	testin isoform 1	99	PET.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding				0	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			ATCCAGTTGCTGCCAAGAAGA	0.383													A	115889257	A	A	115889257	2	1	152	1	0	0	0	0	0	0	0	1	15762	1567	55	5		5	TES	7	115889257	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	8671302	115889257	43249406	57	10550											
GRM8	2918	broad.mit.edu	37	chr7	126542691	126542691	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgcaaaccacacatttcttCgattattggcaagagttcgg	8	10	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr7:126542691C>T	uc003vlr.2	-	5	1372	c.1061G>A	c.(1060-1062)CGA>CAA	p.R354Q	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.R354Q|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.R75Q	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	354	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CACATTTCTTCGATTATTGGC	0.348										HNSCC(24;0.065)			T	126542691	T	T	126542691	3	4	152	1	0	0	0	0	1	0	0	0	6803	884	31	2	1739	2	GRM8	7	126542691	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	10653434	126542691	32595972	58	10551											
AGAP3	116988	broad.mit.edu	37	chr7	150840450	150840450	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggagaaggaacgctggataCgggccaagtatgaacagaag	15	6	0	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr7:150840450C>T	uc003wjg.1	+	17	2299	c.2296C>T	c.(2296-2298)CGG>TGG	p.R766W	AGAP3_uc003wje.1_Missense_Mutation_p.R435W|AGAP3_uc003wjj.1_Missense_Mutation_p.R265W|AGAP3_uc003wjk.1_Missense_Mutation_p.R184W	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	730	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						ACGCTGGATACGGGCCAAGTA	0.622													T	150840450	T	T	150840450	3	4	152	1	0	0	0	0	1	0	0	0	369	527	19	1	2429	1	AGAP3	7	150840450	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	24297759	150840450	8298213	59	10552											
CLVS1	157807	broad.mit.edu	37	chr8	62212806	62212806	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaccattacggcaggaagatTcttttgctgtttgcagccaa	10	9	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr8:62212806T>C	uc003xuh.2	+	2	744	c.420T>C	c.(418-420)ATT>ATC	p.I140I	CLVS1_uc003xug.2_Silent_p.I140I|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Silent_p.I140I	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	140	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						GCAGGAAGATTCTTTTGCTGT	0.448													C	62212806	C	C	62212806	2	2	152	1	0	0	0	0	0	0	0	1	3571	1771	62	4		4	CLVS1	8	62212806	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08		62212806	84151216	60	10553											
C8orf84	157869	broad.mit.edu	37	chr8	73982070	73982070	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggccatctccagaacaaCgaaggctcacagagttcata	8	13	3	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr8:73982070C>T	uc003xzf.2	-	4	852	c.647G>A	c.(646-648)CGT>CAT	p.R216H		NM_153225	NP_694957	Q8IVN8	RPESP_HUMAN	RPE-spondin precursor	216					immune response	extracellular region	polysaccharide binding|scavenger receptor activity				0						TCCAGAACAACGAAGGCTCAC	0.478													T	73982070	T	T	73982070	3	4	152	1	0	0	0	0	1	0	0	0	2440	536	19	1	155	1	C8orf84	8	73982070	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	11769264	73982070	72381952	61	10554											
LAMC3	10319	broad.mit.edu	37	chr9	133948659	133948659	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaggaaggtcccagtcagCcgaccaaatggagccacctg	11	14	2	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr9:133948659C>T	uc004caa.1	+	20	3543	c.3445C>T	c.(3445-3447)CCG>TCG	p.P1149S		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1149	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TCCCAGTCAGCCGACCAAATG	0.582													T	133948659	T	T	133948659	3	4	152	1	0	0	0	0	1	0	0	0	8616	739	26	3	3523	3	LAMC3	9	133948659	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		133948659	7264772	62	10555											
KCNT1	57582	broad.mit.edu	37	chr9	138657034	138657034	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgagttctacgcccacccccGgctccaggtgaggcccctta	10	18	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr9:138657034G>A	uc011mdq.1	+	12	1267	c.1193G>A	c.(1192-1194)CGG>CAG	p.R398Q	KCNT1_uc011mdr.1_Missense_Mutation_p.R225Q|KCNT1_uc010nbf.2_Missense_Mutation_p.R353Q|KCNT1_uc004cgo.1_Missense_Mutation_p.R147Q	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	398						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GCCCACCCCCGGCTCCAGGTG	0.642													A	138657034	A	A	138657034	3	1	152	1	0	0	0	0	1	0	0	0	8091	1116	39	2	1239	2	KCNT1	9	138657034	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	4708375	138657034	2556397	63	10556											
KIAA1462	57608	broad.mit.edu	37	chr10	30315264	30315264	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttcctgaagctcaggactctCatccgtgacactgagctcac	8	14	3	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr10:30315264C>T	uc001iux.2	-	2	3872	c.3813G>A	c.(3811-3813)ATG>ATA	p.M1271I	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.M1133I|KIAA1462_uc009xle.1_Missense_Mutation_p.M1271I	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1271										ovary(4)	4						TCAGGACTCTCATCCGTGACA	0.582													T	30315264	T	T	30315264	3	4	152	1	0	0	0	0	1	0	0	0	8234	826	29	3	274	3	KIAA1462	10	30315264	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		30315264	105219483	64	10557											
RET	5979	broad.mit.edu	37	chr10	43604497	43604497	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agggctggttctcaaccggaAcctctccatctcggagaacc	10	14	3	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr10:43604497A>T	uc001jal.2	+	6	1272	c.1082A>T	c.(1081-1083)AAC>ATC	p.N361I	RET_uc001jak.1_Missense_Mutation_p.N361I|RET_uc010qez.1_Missense_Mutation_p.N107I	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	361	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CTCAACCGGAACCTCTCCATC	0.597		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				T	43604497	T	T	43604497	3	4	152	1	0	0	0	0	1	0	0	0	13235	43	2	5	1104	5	RET	10	43604497	Missense_Mutation	SNP	A	TCGA-19-1390-01A-01D-1495-08	13289233	43604497	91930250	65	10558											
GPRIN2	9721	broad.mit.edu	37	chr10	47000008	47000008	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagcctggaggaggtgccGtcccctgtgcgggatgtgcg	17	12	0	0	rs111800394		TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr10:47000008G>A	uc001jec.2	+	3	1263	c.1128G>A	c.(1126-1128)CCG>CCA	p.P376P	GPRIN2_uc010qfq.1_Silent_p.P139P	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	376											0						AGGAGGTGCCGTCCCCTGTGC	0.657													A	47000008	A	A	47000008	2	1	152	1	0	0	0	0	0	0	0	1	6730	1132	40	1		1	GPRIN2	10	47000008	Silent	SNP	G	TCGA-19-1390-01A-01D-1495-08	3395511	47000008	88534739	66	10559											
ATRNL1	26033	broad.mit.edu	37	chr10	117061475	117061475	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtggtgcagcagtacgaaaCgatgtgttgactctaatgcc	12	8	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr10:117061475C>T	uc001lcg.2	+	17	3126	c.2740C>T	c.(2740-2742)CGA>TGA	p.R914*	ATRNL1_uc010qsm.1_Nonsense_Mutation_p.R89*|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	914	PSI 4.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CAGTACGAAACGATGTGTTGA	0.453													T	117061475	T	T	117061475	4	4	152	1	0	0	0	0	0	1	0	0	1207	528	19	1	2806	1	ATRNL1	10	117061475	Nonsense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	70061467	117061475	18473272	67	10560											
TSPAN4	7106	broad.mit.edu	37	chr11	866600	866600	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccatgaccatgtactgccaAgtggtcaaggcagacaccta	10	12	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr11:866600A>G	uc001lsd.1	+	9	896	c.687A>G	c.(685-687)CAA>CAG	p.Q229Q	TSPAN4_uc001lse.1_Silent_p.Q165Q|TSPAN4_uc001lsf.1_Silent_p.Q229Q|TSPAN4_uc001lsg.1_Silent_p.Q229Q|TSPAN4_uc001lsh.1_Silent_p.Q229Q|TSPAN4_uc001lsi.1_Silent_p.Q229Q|TSPAN4_uc001lsj.1_Silent_p.Q229Q	NM_003271	NP_003262	O14817	TSN4_HUMAN	tetraspanin 4 isoform a	229	Cytoplasmic (Potential).				protein complex assembly	integral to plasma membrane				breast(1)	1		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGTACTGCCAAGTGGTCAAGG	0.642													G	866600	G	G	866600	2	3	152	1	0	0	0	0	0	0	0	1	16646	69	3	4		4	TSPAN4	11	866600	Silent	SNP	A	TCGA-19-1390-01A-01D-1495-08		866600	134139916	68	10561											
OR51S1	119692	broad.mit.edu	37	chr11	4870245	4870245	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaggaagaagtgcattgggCggtgcagggcgggctgcagg	21	6	0	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr11:4870245C>T	uc010qyo.1	-	1	194	c.194G>A	c.(193-195)CGC>CAC	p.R65H		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTGCATTGGGCGGTGCAGGGC	0.572													T	4870245	T	T	4870245	3	4	152	1	0	0	0	0	1	0	0	0	11105	768	27	1	780	1	OR51S1	11	4870245	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	4003645	4870245	130136271	69	10562											
RCN1	5954	broad.mit.edu	37	chr11	32119964	32119964	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agatgctgccacgtgatgagAgaagattcaaagctgcagac	12	8	1	6			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr11:32119964A>G	uc010reb.1	+	3	783	c.517A>G	c.(517-519)AGA>GGA	p.R173G	RCN1_uc010rea.1_Missense_Mutation_p.R122G|RCN1_uc001mtk.2_Missense_Mutation_p.R7G	NM_002901	NP_002892	Q15293	RCN1_HUMAN	reticulocalbin 1 precursor	173	EF-hand 3.					endoplasmic reticulum lumen	calcium ion binding			large_intestine(1)	1	Lung SC(675;0.225)					ACGTGATGAGAGAAGATTCAA	0.433													G	32119964	G	G	32119964	3	3	152	1	0	0	0	0	1	0	0	0	13179	296	11	4	527	4	RCN1	11	32119964	Missense_Mutation	SNP	A	TCGA-19-1390-01A-01D-1495-08	27249719	32119964	102886552	70	10563											
OR4C16	219428	broad.mit.edu	37	chr11	55340233	55340233	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atttgtgcagtgagttatgtCatgctaatattctcctatgt	8	6	2	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr11:55340233C>T	uc010rih.1	+	1	630	c.630C>T	c.(628-630)GTC>GTT	p.V210V		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TGAGTTATGTCATGCTAATAT	0.433													T	55340233	T	T	55340233	2	4	152	1	0	0	0	0	0	0	0	1	11049	813	29	3		3	OR4C16	11	55340233	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	23220269	55340233	79666283	71	10564											
OR5D18	219438	broad.mit.edu	37	chr11	55587827	55587827	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcgccgcaaagccttctccaCctgtgcctcccacctgactg	8	19	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr11:55587827C>A	uc010rin.1	+	1	722	c.722C>A	c.(721-723)ACC>AAC	p.T241N		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GCCTTCTCCACCTGTGCCTCC	0.507													A	55587827	A	A	55587827	3	1	152	1	0	0	0	0	1	0	0	0	11157	507	18	5	724	5	OR5D18	11	55587827	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	247594	55587827	79418689	72	10565											
LPXN	9404	broad.mit.edu	37	chr11	58295179	58295179	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagaaggagccagtagaAaaactggtgaagcagtcctg	12	7	1	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr11:58295179A>G	uc001nmw.2	-	9	1054	c.909T>C	c.(907-909)TTT>TTC	p.F303F	LPXN_uc009ymp.2_Silent_p.F173F|LPXN_uc010rkj.1_Silent_p.F308F|LPXN_uc010rkk.1_Silent_p.F283F	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	303	LIM zinc-binding 3.				cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				AGCCAGTAGAAAAACTGGTGA	0.473													G	58295179	G	G	58295179	2	3	152	1	0	0	0	0	0	0	0	1	8929	11	1	4		4	LPXN	11	58295179	Silent	SNP	A	TCGA-19-1390-01A-01D-1495-08	2707352	58295179	76711337	73	10566											
TYR	7299	broad.mit.edu	37	chr11	88911588	88911588	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtcatccccatagggacctAtggccaaatgaaaaatggat	9	9	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr11:88911588A>G	uc001pcs.2	+	1	549	c.467A>G	c.(466-468)TAT>TGT	p.Y156C		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	156	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	ATAGGGACCTATGGCCAAATG	0.408									Oculocutaneous_Albinism				G	88911588	G	G	88911588	3	3	152	1	0	0	0	0	1	0	0	0	16810	449	16	4	469	4	TYR	11	88911588	Missense_Mutation	SNP	A	TCGA-19-1390-01A-01D-1495-08	30616409	88911588	46094928	74	10567											
FAT3	120114	broad.mit.edu	37	chr11	92577445	92577445	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ttgatgtggtcgtgcatgtgGagcagttggtgcatgagatg	17	4	0	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr11:92577445G>C	uc001pdj.3	+	18	10929	c.10912G>C	c.(10912-10914)GAG>CAG	p.E3638Q	FAT3_uc001pdi.3_Missense_Mutation_p.E78Q	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3638	Cadherin 33.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CGTGCATGTGGAGCAGTTGGT	0.557										TCGA Ovarian(4;0.039)			C	92577445	C	C	92577445	3	2	152	1	0	0	0	0	1	0	0	0	5691	1175	41	5	10982	5	FAT3	11	92577445	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	3665857	92577445	42429071	75	10568											
OR10G8	219869	broad.mit.edu	37	chr11	123901051	123901051	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cagagcctttcagacctgtgCctcccactgtatcgtggtcc	9	15	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr11:123901051C>G	uc001pzp.1	+	1	722	c.722C>G	c.(721-723)GCC>GGC	p.A241G		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CAGACCTGTGCCTCCCACTGT	0.547													G	123901051	G	G	123901051	3	3	152	1	0	0	0	0	1	0	0	0	10903	739	26	5	724	5	OR10G8	11	123901051	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	31323606	123901051	11105465	76	10569											
CACNA1C	775	broad.mit.edu	37	chr12	2675631	2675631	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttctgcagaaggaagtgcCgcgccgcagtcaagtctaat	13	10	3	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr12:2675631C>T	uc009zdu.1	+	12	1865	c.1552C>T	c.(1552-1554)CGC>TGC	p.R518C	CACNA1C_uc009zdv.1_Missense_Mutation_p.R515C|CACNA1C_uc001qkb.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkc.2_Missense_Mutation_p.R518C|CACNA1C_uc001qke.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkf.2_Missense_Mutation_p.R518C|CACNA1C_uc001qjz.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkd.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkg.2_Missense_Mutation_p.R518C|CACNA1C_uc009zdw.1_Missense_Mutation_p.R518C|CACNA1C_uc001qkh.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkl.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkn.2_Missense_Mutation_p.R518C|CACNA1C_uc001qko.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkp.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkr.2_Missense_Mutation_p.R518C|CACNA1C_uc001qku.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkq.2_Missense_Mutation_p.R518C|CACNA1C_uc001qks.2_Missense_Mutation_p.R518C|CACNA1C_uc001qkt.2_Missense_Mutation_p.R518C|CACNA1C_uc001qka.1_Missense_Mutation_p.R53C|CACNA1C_uc001qki.1_Missense_Mutation_p.R254C|CACNA1C_uc001qkj.1_Missense_Mutation_p.R254C|CACNA1C_uc001qkk.1_Missense_Mutation_p.R254C|CACNA1C_uc001qkm.1_Missense_Mutation_p.R254C|CACNA1C_uc009zdy.1_Missense_Mutation_p.R183C|CACNA1C_uc001qkv.1_Missense_Mutation_p.R88C	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	518	II.|Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AAGGAAGTGCCGCGCCGCAGT	0.562													T	2675631	T	T	2675631	3	4	152	1	0	0	0	0	1	0	0	0	2540	652	23	2	1706	2	CACNA1C	12	2675631	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		2675631	131176264	77	10570											
CREBL2	1389	broad.mit.edu	37	chr12	12765120	12765120	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgccgcgatggatgacagtaAggtaagtcttgtggtttgca	14	6	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr12:12765120A>C	uc001rap.1	+	1	290	c.14A>C	c.(13-15)AAG>ACG	p.K5T		NM_001310	NP_001301	O60519	CRBL2_HUMAN	cAMP responsive element binding protein-like 2	5					cell cycle|signal transduction	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Prostate(47;0.0684)		BRCA - Breast invasive adenocarcinoma(232;0.0503)		GATGACAGTAAGGTAAGTCTT	0.677													C	12765120	C	C	12765120	3	2	152	1	0	0	0	0	1	0	0	0	3862	86	3	5	16	5	CREBL2	12	12765120	Missense_Mutation	SNP	A	TCGA-19-1390-01A-01D-1495-08	10089489	12765120	121086775	78	10571											
CNTN1	1272	broad.mit.edu	37	chr12	41410534	41410534	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aattttggttacatagtggcAtttaagccatttgatggaga	10	4	0	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr12:41410534A>T	uc001rmm.1	+	19	2348	c.2235A>T	c.(2233-2235)GCA>GCT	p.A745A	CNTN1_uc001rmn.1_Silent_p.A734A	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	745	Fibronectin type-III 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				ACATAGTGGCATTTAAGCCAT	0.368													T	41410534	T	T	41410534	2	4	152	1	0	0	0	0	0	0	0	1	3640	204	8	5		5	CNTN1	12	41410534	Silent	SNP	A	TCGA-19-1390-01A-01D-1495-08	28645414	41410534	92441361	79	10572											
SRGAP1	57522	broad.mit.edu	37	chr12	64491111	64491111	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttccgtgggctggaaaaccCcctctttcctaaggaaagat	9	11	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr12:64491111C>T	uc010ssp.1	+	15	1825	c.1769C>T	c.(1768-1770)CCC>CTC	p.P590L	SRGAP1_uc001srv.2_Missense_Mutation_p.P527L	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	590	Rho-GAP.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CTGGAAAACCCCCTCTTTCCT	0.378													T	64491111	T	T	64491111	3	4	152	1	0	0	0	0	1	0	0	0	15144	623	22	3	1827	3	SRGAP1	12	64491111	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	23080577	64491111	69360784	80	10573											
PTPRB	5787	broad.mit.edu	37	chr12	70949684	70949684	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atagtgctgtcttcaaccacCtcgctggtcatgccggccga	10	14	3	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr12:70949684C>T	uc001swb.3	-	17	4335	c.4305G>A	c.(4303-4305)GAG>GAA	p.E1435E	PTPRB_uc010sto.1_Silent_p.E1345E|PTPRB_uc010stp.1_Silent_p.E1345E|PTPRB_uc001swc.3_Silent_p.E1653E|PTPRB_uc001swa.3_Silent_p.E1565E	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1435	Fibronectin type-III 16.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTTCAACCACCTCGCTGGTCA	0.527													T	70949684	T	T	70949684	2	4	152	1	0	0	0	0	0	0	0	1	12796	680	24	3		3	PTPRB	12	70949684	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	6458573	70949684	62902211	81	10574											
PABPC3	5042	broad.mit.edu	37	chr13	25671682	25671682	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaataagcccagtgctatccGcccaggtgctcctagagtac	9	13	0	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr13:25671682G>A	uc001upy.2	+	1	1407	c.1346G>A	c.(1345-1347)CGC>CAC	p.R449H		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	449					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AGTGCTATCCGCCCAGGTGCT	0.502													A	25671682	A	A	25671682	3	1	152	1	0	0	0	0	1	0	0	0	11365	1087	38	1	1348	1	PABPC3	13	25671682	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08		25671682	89498196	82	10575											
ATP8A2	51761	broad.mit.edu	37	chr13	26273468	26273468	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggcactctcgtgcaaagCggtcatatgctgcaggtagg	13	9	2	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr13:26273468C>T	uc001uqk.2	+	25	2511	c.2369C>T	c.(2368-2370)GCG>GTG	p.A790V	ATP8A2_uc010tdi.1_Missense_Mutation_p.A750V|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.A340V	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	750	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TCGTGCAAAGCGGTCATATGC	0.522													T	26273468	T	T	26273468	3	4	152	1	0	0	0	0	1	0	0	0	1193	768	27	1	2467	1	ATP8A2	13	26273468	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	601786	26273468	88896410	83	10576											
RNASEH2B	79621	broad.mit.edu	37	chr13	51530575	51530575	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaagtattgataccttttttGgggtaaaaaataaaaaaaaa	6	2	0	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr13:51530575G>C	uc001vfa.3	+	11	1225	c.904G>C	c.(904-906)GGG>CGG	p.G302R	RNASEH2B_uc001vfb.3_Intron	NM_024570	NP_078846	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B isoform 1	302					RNA catabolic process	nucleus|ribonuclease H2 complex					0		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		TACCTTTTTTGGGGTAAAAAA	0.299													C	51530575	C	C	51530575	3	2	152	1	0	0	0	0	1	0	0	0	13413	1348	47	5	946	5	RNASEH2B	13	51530575	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	25257107	51530575	63639303	84	10577											
PCDH20	64881	broad.mit.edu	37	chr13	61985658	61985658	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atattaatctctggttctttTcttaaaagactctcaatgta	4	7	4	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr13:61985658T>C	uc001vid.3	-	2	2938	c.2574A>G	c.(2572-2574)AGA>AGG	p.R858R	PCDH20_uc010thj.1_Silent_p.R858R	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	831	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		CTGGTTCTTTTCTTAAAAGAC	0.408													C	61985658	C	C	61985658	2	2	152	1	0	0	0	0	0	0	0	1	11515	1780	62	4		4	PCDH20	13	61985658	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	10455083	61985658	53184220	85	10578											
MYO16	23026	broad.mit.edu	37	chr13	109859100	109859100	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agggtgcctcccccaccaccTtgcaagaagcccagccttct	8	18	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr13:109859100T>C	uc001vqt.1	+	35	5619	c.5493T>C	c.(5491-5493)CCT>CCC	p.P1831P	MYO16_uc010agk.1_Silent_p.P1853P	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1831					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCCCACCACCTTGCAAGAAGC	0.597													C	109859100	C	C	109859100	2	2	152	1	0	0	0	0	0	0	0	1	10064	1596	56	4		4	MYO16	13	109859100	Silent	SNP	T	TCGA-19-1390-01A-01D-1495-08	47873442	109859100	5310778	86	10579											
FKBP3	2287	broad.mit.edu	37	chr14	45587256	45587256	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcaggctgtcctttctttcCgtaagcccattctggttcaa	7	12	4	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr14:45587256C>T	uc010tqf.1	-	6	668	c.595G>A	c.(595-597)GGA>AGA	p.G199R		NM_002013	NP_002004	Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	199	PPIase FKBP-type.				protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity				0						CCTTTCTTTCCGTAAGCCCAT	0.378													T	45587256	T	T	45587256	3	4	152	1	0	0	0	0	1	0	0	0	5909	661	23	2	87	2	FKBP3	14	45587256	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		45587256	61762284	87	10580											
SPINT1	6692	broad.mit.edu	37	chr15	41146113	41146113	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcagctctggggctcaggCgactttcccccagggtgagt	15	12	2	1	rs145193299		TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr15:41146113C>T	uc001zna.2	+	5	1151	c.947C>T	c.(946-948)GCG>GTG	p.A316V	SPINT1_uc001znb.2_Intron|SPINT1_uc001znc.2_Intron|SPINT1_uc010ucs.1_Missense_Mutation_p.A316V	NM_181642	NP_857593	O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	316						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GGGGCTCAGGCGACTTTCCCC	0.592													T	41146113	T	T	41146113	3	4	152	1	0	0	0	0	1	0	0	0	15067	768	27	1	961	1	SPINT1	15	41146113	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		41146113	61385279	88	10581											
PLA2G4D	283748	broad.mit.edu	37	chr15	42364081	42364081	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gccccgtacttcaggaaaccGacctcatagggggagaactc	11	13	2	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr15:42364081G>A	uc001zox.2	-	15	1559	c.1464C>T	c.(1462-1464)GTC>GTT	p.V488V		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	488	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		TCAGGAAACCGACCTCATAGG	0.607													A	42364081	A	A	42364081	2	1	152	1	0	0	0	0	0	0	0	1	12004	1045	37	2		2	PLA2G4D	15	42364081	Silent	SNP	G	TCGA-19-1390-01A-01D-1495-08	1217968	42364081	60167311	89	10582											
ATP8B4	79895	broad.mit.edu	37	chr15	50211036	50211036	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aacatccattttcaagttacCttgtttgtctcctgttagga	6	9	2	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr15:50211036C>A	uc001zxu.2	-	19	2177	c.2035G>T	c.(2035-2037)GAA>TAA	p.E679*	ATP8B4_uc010ber.2_Nonsense_Mutation_p.E552*|ATP8B4_uc010ufd.1_Nonsense_Mutation_p.E489*|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	679	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTCAAGTTACCTTGTTTGTCT	0.318													A	50211036	A	A	50211036	4	1	152	1	0	0	0	0	0	1	0	0	1197	695	24	5	1583	5	ATP8B4	15	50211036	Nonsense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	7846955	50211036	52320356	90	10583											
ADAM10	102	broad.mit.edu	37	chr15	58925426	58925426	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agttatgtccaacttcgtgaGcaaaagtaatgtgagagact	10	6	0	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr15:58925426G>A	uc002afd.1	-	9	1589	c.1145C>T	c.(1144-1146)GCT>GTT	p.A382V	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Missense_Mutation_p.A81V|ADAM10_uc002afe.1_Intron	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	382	Peptidase M12B.|Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		AACTTCGTGAGCAAAAGTAAT	0.328													A	58925426	A	A	58925426	3	1	152	1	0	0	0	0	1	0	0	0	234	971	34	3	1133	3	ADAM10	15	58925426	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	8714390	58925426	43605966	91	10584											
TMEM202	338949	broad.mit.edu	37	chr15	72700088	72700088	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcctgcctgtgatgaaaacGtcactgtgattccaacagag	10	11	1	4	rs143076809		TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr15:72700088G>A	uc002auq.2	+	5	676	c.676G>A	c.(676-678)GTC>ATC	p.V226I	TMEM202_uc002aur.2_RNA	NM_001080462	NP_001073931	A6NGA9	TM202_HUMAN	transmembrane protein 202	226						integral to membrane				central_nervous_system(1)|skin(1)	2						TGATGAAAACGTCACTGTGAT	0.478													A	72700088	A	A	72700088	3	1	152	1	0	0	0	0	1	0	0	0	16124	1145	40	1	694	1	TMEM202	15	72700088	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	13774662	72700088	29831304	92	10585											
SCAMP5	192683	broad.mit.edu	37	chr15	75305137	75305137	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaccaagcgcctctactacCtctggatgtgtgagtgccat	10	12	2	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr15:75305137C>T	uc002azk.1	+	3	289	c.127C>T	c.(127-129)CTC>TTC	p.L43F	SCAMP5_uc002azl.1_Missense_Mutation_p.L43F|SCAMP5_uc002azm.1_Missense_Mutation_p.L43F|SCAMP5_uc002azn.1_Missense_Mutation_p.L43F|SCAMP5_uc010uly.1_Missense_Mutation_p.P24L	NM_138967	NP_620417	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	43	Helical; (Potential).				exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						CCTCTACTACCTCTGGATGTG	0.607													T	75305137	T	T	75305137	3	4	152	1	0	0	0	0	1	0	0	0	13874	681	24	3	133	3	SCAMP5	15	75305137	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	2605049	75305137	27226255	93	10586											
CORO1A	11151	broad.mit.edu	37	chr16	30198720	30198720	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggagaaggaccgtccccaCgaggggacccggcccgtgcg	16	15	0	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr16:30198720C>T	uc002dww.2	+	6	776	c.654C>T	c.(652-654)CAC>CAT	p.H218H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Silent_p.H218H|CORO1A_uc010bzr.2_Silent_p.H218H|CORO1A_uc002dwx.2_Silent_p.H112H|CORO1A_uc002dwy.1_Silent_p.H62H|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	218	WD 5.				cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						ACCGTCCCCACGAGGGGACCC	0.667													T	30198720	T	T	30198720	2	4	152	1	0	0	0	0	0	0	0	1	3753	535	19	1		1	CORO1A	16	30198720	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08		30198720	60156033	94	10587											
ARMC5	79798	broad.mit.edu	37	chr16	31471307	31471307	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagtgcgcagactcggaggCatactccctttgggtaagtg	14	9	0	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr16:31471307C>T	uc002ecc.2	+	1	991	c.462C>T	c.(460-462)GGC>GGT	p.G154G	ARMC5_uc010vfn.1_Silent_p.G249G|ARMC5_uc010vfo.1_Silent_p.G186G|ARMC5_uc002eca.3_Silent_p.G154G|ARMC5_uc010vfp.1_Silent_p.G154G|ARMC5_uc002ecb.2_Silent_p.G154G	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	154	ARM 1.						binding			pancreas(1)	1						GACTCGGAGGCATACTCCCTT	0.597													T	31471307	T	T	31471307	2	4	152	1	0	0	0	0	0	0	0	1	954	697	25	3		3	ARMC5	16	31471307	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	1272587	31471307	58883446	95	10588											
LRRC50	123872	broad.mit.edu	37	chr16	84203678	84203678	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtccagagccagaggggaCcctcccagctgagaccctgc	13	15	0	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr16:84203678C>T	uc002fhl.3	+	8	1425	c.1244C>T	c.(1243-1245)ACC>ATC	p.T415I	LRRC50_uc010vnw.1_Missense_Mutation_p.T179I	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	415	Pro-rich.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						CCAGAGGGGACCCTCCCAGCT	0.617									Kartagener_syndrome				T	84203678	T	T	84203678	3	4	152	1	0	0	0	0	1	0	0	0	9009	507	18	3	1274	3	LRRC50	16	84203678	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	52732371	84203678	6151075	96	10589											
TP53	7157	broad.mit.edu	37	chr17	7578268	7578268	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatttccttccactcggataAgatgctgaggaggggccaga	12	9	0	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr17:7578268A>C	uc002gim.2	-	6	775	c.581T>G	c.(580-582)CTT>CGT	p.L194R	TP53_uc002gig.1_Missense_Mutation_p.L194R|TP53_uc002gih.2_Missense_Mutation_p.L194R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L62R|TP53_uc010cng.1_Missense_Mutation_p.L62R|TP53_uc002gii.1_Missense_Mutation_p.L62R|TP53_uc010cnh.1_Missense_Mutation_p.L194R|TP53_uc010cni.1_Missense_Mutation_p.L194R|TP53_uc002gij.2_Missense_Mutation_p.L194R|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.L101R|TP53_uc002gio.2_Missense_Mutation_p.L62R|TP53_uc010vug.1_Missense_Mutation_p.L155R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	194	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> H (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(31)|p.L194F(16)|p.L194P(8)|p.0?(7)|p.L194H(5)|p.L194L(4)|p.A189_V197delAPPQHLIRV(4)|p.P191fs*53(2)|p.L194fs*15(2)|p.K164_P219del(1)|p.A189fs*53(1)|p.L194V(1)|p.L194fs*14(1)|p.P191fs*6(1)|p.I195fs*52(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.L194I(1)|p.L194fs*52(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACTCGGATAAGATGCTGAGG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578268	C	C	7578268	3	2	152	1	0	0	0	0	1	0	0	0	16378	72	3	5	713	5	TP53	17	7578268	Missense_Mutation	SNP	A	TCGA-19-1390-01A-01D-1495-08		7578268	73616942	97	10590											
TP53	7157	broad.mit.edu	37	chr17	7578542	7578542	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggcaaaacatcttgttgaGggcaggggagtactgtagga	15	5	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr17:7578542G>A	uc002gim.2	-	5	582	c.388C>T	c.(388-390)CTC>TTC	p.L130F	TP53_uc002gig.1_Missense_Mutation_p.L130F|TP53_uc002gih.2_Missense_Mutation_p.L130F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.L130F|TP53_uc010cni.1_Missense_Mutation_p.L130F|TP53_uc002gij.2_Missense_Mutation_p.L130F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.L37F|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.L91F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	130	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> H (in sporadic cancers; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> I (in a sporadic cancer; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L130V(11)|p.L130F(7)|p.L130R(7)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.L130L(4)|p.L130H(3)|p.Y126_N131delYSPALN(3)|p.L130fs*19(2)|p.L130fs*41(2)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.A129_L130insXX(1)|p.A129_N131delALN(1)|p.L130P(1)|p.V73fs*9(1)|p.Y126fs*18(1)|p.L130fs*39(1)|p.L130fs*16(1)|p.A129_K132delALNK(1)|p.L130_M133delLNKM(1)|p.N131fs*27(1)|p.P13fs*18(1)|p.S127fs*36(1)|p.L130del(1)|p.L130fs*40(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTTGTTGAGGGCAGGGGAG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578542	A	A	7578542	3	1	152	1	0	0	0	0	1	0	0	0	16378	1000	35	3	910	3	TP53	17	7578542	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	274	7578542	73616668	98	10591											
RCVRN	5957	broad.mit.edu	37	chr17	9808118	9808118	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggggagaggggagactgaccAtgacgatctccagcacttca	14	10	2	4			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr17:9808118A>G	uc002gme.1	-	1	567	c.380T>C	c.(379-381)ATG>ACG	p.M127T		NM_002903	NP_002894	P35243	RECO_HUMAN	recoverin	127	EF-hand 3.				visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0						GAGACTGACCATGACGATCTC	0.642													G	9808118	G	G	9808118	3	3	152	1	0	0	0	0	1	0	0	0	13186	231	8	4	234	4	RCVRN	17	9808118	Missense_Mutation	SNP	A	TCGA-19-1390-01A-01D-1495-08	2229576	9808118	71387092	99	10592											
MYH4	4622	broad.mit.edu	37	chr17	10358321	10358321	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctgcatatggcttgagtgCgcgtgatgagttgagctagc	14	8	1	4	rs144778193	by1000genomes	TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr17:10358321C>T	uc002gmn.2	-	21	2483	c.2372G>A	c.(2371-2373)CGC>CAC	p.R791H	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	791	IQ.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GGCTTGAGTGCGCGTGATGAG	0.463													T	10358321	T	T	10358321	3	4	152	1	0	0	0	0	1	0	0	0	10037	768	27	1	3527	1	MYH4	17	10358321	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	550203	10358321	70836889	100	10593											
MYH1	4619	broad.mit.edu	37	chr17	10419368	10419368	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctggcaaccacttgtaggggTtgacagtgacacagaacaag	12	9	0	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr17:10419368T>A	uc002gmo.2	-	5	474	c.380A>T	c.(379-381)AAC>ATC	p.N127I	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	127	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CTTGTAGGGGTTGACAGTGAC	0.488													A	10419368	A	A	10419368	3	1	152	1	0	0	0	0	1	0	0	0	10029	1725	60	5	5583	5	MYH1	17	10419368	Missense_Mutation	SNP	T	TCGA-19-1390-01A-01D-1495-08	61047	10419368	70775842	101	10594											
ACCN1	40	broad.mit.edu	37	chr17	31341024	31341024	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtccccagggtcgtctgcaGgggcacgttcacagtgtgac	15	12	2	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr17:31341024G>T	uc002hhu.2	-	10	1772	c.1498C>A	c.(1498-1500)CTG>ATG	p.L500M	ACCN1_uc002hht.2_Missense_Mutation_p.L551M	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	500	Cytoplasmic (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GTCGTCTGCAGGGGCACGTTC	0.557													T	31341024	T	T	31341024	3	4	152	1	0	0	0	0	1	0	0	0	128	991	35	5	44	5	ACCN1	17	31341024	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	20921656	31341024	49854186	102	10595											
ERBB2	2064	broad.mit.edu	37	chr17	37866667	37866667	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcacctacaacacagacacGtttgagtccatgcccaatcc	6	15	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr17:37866667G>A	uc002hso.2	+	7	1072	c.834G>A	c.(832-834)ACG>ACA	p.T278T	ERBB2_uc002hsm.2_Silent_p.T248T|ERBB2_uc010cwa.2_Silent_p.T263T|ERBB2_uc002hsp.2_Silent_p.T81T|ERBB2_uc010cwb.2_Silent_p.T278T|ERBB2_uc010wek.1_Intron|ERBB2_uc002hsl.2_Silent_p.T248T|ERBB2_uc002hsn.1_Silent_p.T278T	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	278	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ACACAGACACGTTTGAGTCCA	0.582		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			A	37866667	A	A	37866667	2	1	152	1	0	0	0	0	0	0	0	1	5206	1132	40	1		1	ERBB2	17	37866667	Silent	SNP	G	TCGA-19-1390-01A-01D-1495-08	6525643	37866667	43328543	103	10596											
DNAH17	8632	broad.mit.edu	37	chr17	76457727	76457727	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctggatcagttggtctgCgctctcattcttctgcttga	9	12	5	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr17:76457727C>T	uc010dhp.1	-	3	460	c.238G>A	c.(238-240)GCA>ACA	p.A80T	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGTTGGTCTGCGCTCTCATTC	0.527													T	76457727	T	T	76457727	3	4	152	1	0	0	0	0	1	0	0	0	4601	768	27	1	4246	1	DNAH17	17	76457727	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	38591060	76457727	4737483	104	10597											
DSG3	1830	broad.mit.edu	37	chr18	29046572	29046572	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aattgtccaacagctgtcctCgaaaaagatgcagtttgcag	9	9	0	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr18:29046572C>T	uc002kws.2	+	11	1600	c.1491C>T	c.(1489-1491)CTC>CTT	p.L497L		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	497	Cadherin 4.|Extracellular (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAGCTGTCCTCGAAAAAGATG	0.418													T	29046572	T	T	29046572	2	4	152	1	0	0	0	0	0	0	0	1	4778	871	31	2		2	DSG3	18	29046572	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08		29046572	49030676	105	10598											
DSG3	1830	broad.mit.edu	37	chr18	29055684	29055684	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatctatgataatgaaggcGcagatgccactggttctcct	10	9	2	4	rs148716637		TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr18:29055684G>A	uc002kws.2	+	16	2570	c.2461G>A	c.(2461-2463)GCA>ACA	p.A821T	DSG3_uc002kwt.2_Missense_Mutation_p.A103T	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	821	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TAATGAAGGCGCAGATGCCAC	0.468													A	29055684	A	A	29055684	3	1	152	1	0	0	0	0	1	0	0	0	4778	1087	38	1	2523	1	DSG3	18	29055684	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	9112	29055684	49021564	106	10599											
SERPINB12	89777	broad.mit.edu	37	chr18	61232706	61232706	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagagtgtgaagatgatgaCgcaaaaaggcctctacagaa	11	7	1	6			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr18:61232706C>T	uc010xen.1	+	6	674	c.674C>T	c.(673-675)ACG>ATG	p.T225M	SERPINB12_uc010xeo.1_Missense_Mutation_p.T245M	NM_080474	NP_536722	Q96P63	SPB12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	225					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity				0						AAGATGATGACGCAAAAAGGC	0.488													T	61232706	T	T	61232706	3	4	152	1	0	0	0	0	1	0	0	0	14099	536	19	1	696	1	SERPINB12	18	61232706	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	32177022	61232706	16844542	107	10600											
VMAC	400673	broad.mit.edu	37	chr19	5909016	5909016	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tggatgccctggctgaggctGagcgcctggggcccctgccg	17	14	0	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:5909016G>A	uc002mds.3	+	2	423	c.373G>A	c.(373-375)GAG>AAG	p.E125K		NM_001017921	NP_001017921	Q2NL98	VMAC_HUMAN	vimentin-type IF-associated coiled-coil protein	125						cytoplasm					0						GGCTGAGGCTGAGCGCCTGGG	0.721													A	5909016	A	A	5909016	3	1	152	1	0	0	0	0	1	0	0	0	17173	1291	45	3	379	3	VMAC	19	5909016	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08		5909016	53219967	108	10601											
LASS4	79603	broad.mit.edu	37	chr19	8316117	8316117	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctggtcctcctggccatgCgccttgcctttgagaggtga	13	13	0	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:8316117C>T	uc002mjg.2	+	3	477	c.157C>T	c.(157-159)CGC>TGC	p.R53C	LASS4_uc002mjh.2_Missense_Mutation_p.R2C|LASS4_uc002mji.2_Intron|LASS4_uc010dvz.2_Missense_Mutation_p.R53C	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4	53						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						CCTGGCCATGCGCCTTGCCTT	0.627													T	8316117	T	T	8316117	3	4	152	1	0	0	0	0	1	0	0	0	8641	768	27	1	159	1	LASS4	19	8316117	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	2407101	8316117	50812866	109	10602											
MUC16	94025	broad.mit.edu	37	chr19	8966765	8966765	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctactctccgagccagtggCgagaagttacacagggagtc	12	11	2	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:8966765C>T	uc002mkp.2	-	81	43392	c.43188G>A	c.(43186-43188)TCG>TCA	p.S14396S	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.S1196S|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGCCAGTGGCGAGAAGTTAC	0.527													T	8966765	T	T	8966765	2	4	152	1	0	0	0	0	0	0	0	1	9973	755	27	1		1	MUC16	19	8966765	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	650648	8966765	50162218	110	10603											
MUC16	94025	broad.mit.edu	37	chr19	9057573	9057573	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccaggagaacttttttggGtggtgatggtcatttgtgtt	13	6	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:9057573G>A	uc002mkp.2	-	3	30077	c.29873C>T	c.(29872-29874)ACC>ATC	p.T9958I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9960	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTTTTTTGGGTGGTGATGGT	0.488													A	9057573	A	A	9057573	3	1	152	1	0	0	0	0	1	0	0	0	9973	1261	44	3	13978	3	MUC16	19	9057573	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	90808	9057573	50071410	111	10604											
ZNF443	10224	broad.mit.edu	37	chr19	12543219	12543219	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tttcctgggatatctatattGatcttcaatgttctggtctt	7	7	5	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:12543219G>T	uc002mtu.2	-	3	361	c.163C>A	c.(163-165)CAA>AAA	p.Q55K		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	55	KRAB.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						TATCTATATTGATCTTCAATG	0.294													T	12543219	T	T	12543219	3	4	152	1	0	0	0	0	1	0	0	0	17913	1299	45	5	1860	5	ZNF443	19	12543219	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	3485646	12543219	46585764	112	10605											
OR7A17	26333	broad.mit.edu	37	chr19	14991689	14991689	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acagccacaataccattaagCtttgtgacaaggaattcagg	8	9	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:14991689C>A	uc010xob.1	-	1	479	c.479G>T	c.(478-480)AGC>ATC	p.S160I		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					TACCATTAAGCTTTGTGACAA	0.483													A	14991689	A	A	14991689	3	1	152	1	0	0	0	0	1	0	0	0	11215	797	28	5	452	5	OR7A17	19	14991689	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	2448470	14991689	44137294	113	10606											
ZNF208	7757	broad.mit.edu	37	chr19	22155210	22155210	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aattttcttatgataactaaGggttgagggccatttatagg	10	4	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:22155210G>T	uc002nqp.2	-	5	2475	c.2326C>A	c.(2326-2328)CTT>ATT	p.L776I	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGATAACTAAGGGTTGAGGGC	0.363													T	22155210	T	T	22155210	3	4	152	1	0	0	0	0	1	0	0	0	17763	1000	35	5	1220	5	ZNF208	19	22155210	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	7163521	22155210	36973773	114	10607											
MAG	4099	broad.mit.edu	37	chr19	35801000	35801000	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggcccaggccccgccccgCgtcatctgcaccgcgaggaa	12	19	2	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:35801000C>T	uc002nyy.1	+	8	1604	c.1455C>T	c.(1453-1455)CGC>CGT	p.R485R	MAG_uc002nyx.1_Silent_p.R485R|MAG_uc010eds.1_Silent_p.R460R|MAG_uc002nyz.1_Silent_p.R485R	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	485	Ig-like C2-type 4.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCCCGCCCCGCGTCATCTGCA	0.697													T	35801000	T	T	35801000	2	4	152	1	0	0	0	0	0	0	0	1	9162	755	27	1		1	MAG	19	35801000	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	13645790	35801000	23327983	115	10608											
CGB7	94027	broad.mit.edu	37	chr19	49557640	49557640	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttgaggaagaggaggcctGgaagcgggggtcatcacagg	18	7	2	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:49557640G>A	uc002pmd.2	-	3	771	c.406C>T	c.(406-408)CAG>TAG	p.Q136*	CGB_uc010yad.1_Intron|CGB8_uc002pmc.2_Intron|CGB7_uc002pme.2_Nonsense_Mutation_p.Q136*	NM_033142	NP_149133	P01233	CGHB_HUMAN	chorionic gonadotropin, beta polypeptide 7	136					apoptosis|cell-cell signaling|cellular nitrogen compound metabolic process|female gamete generation|hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Choriogonadotropin alfa(DB00097)	GAGGAGGCCTGGAAGCGGGGG	0.647													A	49557640	A	A	49557640	4	1	152	1	0	0	0	0	0	1	0	0	3300	1357	47	3	95	3	CGB7	19	49557640	Nonsense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	13756640	49557640	9571343	116	10609											
ZNF28	7576	broad.mit.edu	37	chr19	53304049	53304049	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acttgtaaggtttctctccaGtgtgaattatagtatgtttt	8	5	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:53304049G>T	uc002qad.2	-	4	1169	c.1049C>A	c.(1048-1050)ACT>AAT	p.T350N	ZNF28_uc002qac.2_Missense_Mutation_p.T297N|ZNF28_uc010eqe.2_Missense_Mutation_p.T296N	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TTTCTCTCCAGTGTGAATTAT	0.373													T	53304049	T	T	53304049	3	4	152	1	0	0	0	0	1	0	0	0	17810	1029	36	5	1111	5	ZNF28	19	53304049	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	3746409	53304049	5824934	117	10610											
NLRP7	199713	broad.mit.edu	37	chr19	55451268	55451268	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgccaggagctggaggtcccTcagtgccctgggccgcgtgg	17	14	1	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:55451268T>C	uc002qih.3	-	4	995	c.919A>G	c.(919-921)AGG>GGG	p.R307G	NLRP7_uc002qig.3_Missense_Mutation_p.R307G|NLRP7_uc002qii.3_Missense_Mutation_p.R307G|NLRP7_uc010esk.2_Missense_Mutation_p.R307G|NLRP7_uc010esl.2_Missense_Mutation_p.R335G	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	307	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TGGAGGTCCCTCAGTGCCCTG	0.617													C	55451268	C	C	55451268	3	2	152	1	0	0	0	0	1	0	0	0	10482	1550	54	4	2226	4	NLRP7	19	55451268	Missense_Mutation	SNP	T	TCGA-19-1390-01A-01D-1495-08	2147219	55451268	3677715	118	10611											
NLRP5	126206	broad.mit.edu	37	chr19	56549462	56549462	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttacgacctcccccagccTgaaatctctgagcctggcag	8	17	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr19:56549462T>C	uc002qmj.2	+	10	2687	c.2687T>C	c.(2686-2688)CTG>CCG	p.L896P	NLRP5_uc002qmi.2_Missense_Mutation_p.L877P	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	896	LRR 7.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCCCCCAGCCTGAAATCTCTG	0.547													C	56549462	C	C	56549462	3	2	152	1	0	0	0	0	1	0	0	0	10480	1580	55	4	2725	4	NLRP5	19	56549462	Missense_Mutation	SNP	T	TCGA-19-1390-01A-01D-1495-08	1098194	56549462	2579521	119	10612											
BPIL3	128859	broad.mit.edu	37	chr20	31630672	31630672	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atctcgaagaagcctacatcCcagttgtcaatggtgagggt	11	9	2	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr20:31630672C>A	uc010zuc.1	+	13	1240	c.1240C>A	c.(1240-1242)CCA>ACA	p.P414T	BPIL3_uc010zud.1_Missense_Mutation_p.P353T	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	414						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						AGCCTACATCCCAGTTGTCAA	0.473													A	31630672	A	A	31630672	3	1	152	1	0	0	0	0	1	0	0	0	1493	623	22	5	1290	5	BPIL3	20	31630672	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		31630672	31394848	120	10613											
CBFA2T2	9139	broad.mit.edu	37	chr20	32232172	32232172	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaactgctggaactgtggccGcaaagccagcgagacatgca	13	11	0	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr20:32232172G>A	uc002wzg.1	+	12	2072	c.1535G>A	c.(1534-1536)CGC>CAC	p.R512H	CBFA2T2_uc010zug.1_Missense_Mutation_p.R286H|CBFA2T2_uc002wze.1_Missense_Mutation_p.R503H|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Missense_Mutation_p.R483H|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA|CBFA2T2_uc002wzk.1_Missense_Mutation_p.R60H	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	512						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						AACTGTGGCCGCAAAGCCAGC	0.542													A	32232172	A	A	32232172	3	1	152	1	0	0	0	0	1	0	0	0	2697	1087	38	1	1615	1	CBFA2T2	20	32232172	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	601500	32232172	30793348	121	10614											
TSHZ2	128553	broad.mit.edu	37	chr20	51870661	51870661	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccgatgccgacagtgcagcGcggcctatgacaccctagtc	11	15	0	1	rs141167641	by1000genomes	TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr20:51870661G>A	uc002xwo.2	+	2	1620	c.664G>A	c.(664-666)GCG>ACG	p.A222T		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	222	C2H2-type 1.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A222T(1)		ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			ACAGTGCAGCGCGGCCTATGA	0.562													A	51870661	A	A	51870661	3	1	152	1	0	0	0	0	1	0	0	0	16621	1087	38	1	670	1	TSHZ2	20	51870661	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	19638489	51870661	11154859	122	10615											
GRIK1	2897	broad.mit.edu	37	chr21	30949385	30949385	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tatgggggattccattctctCtactgtcaagaaggcagcca	10	10	3	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr21:30949385C>G	uc002yno.1	-	14	2493	c.2029G>C	c.(2029-2031)GAG>CAG	p.E677Q	GRIK1_uc002ynn.2_Missense_Mutation_p.E662Q|GRIK1_uc011acs.1_Missense_Mutation_p.E677Q|GRIK1_uc011act.1_Missense_Mutation_p.E538Q	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	677	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TCCATTCTCTCTACTGTCAAG	0.448													G	30949385	G	G	30949385	3	3	152	1	0	0	0	0	1	0	0	0	6773	922	32	5	903	5	GRIK1	21	30949385	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		30949385	17180510	123	10616											
C21orf29	54084	broad.mit.edu	37	chr21	45949800	45949800	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gacacagccttggggtggcgTctgagcccggcagcaggacc	16	13	1	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chr21:45949800T>C	uc002zfe.1	-	5	737	c.671A>G	c.(670-672)GAC>GGC	p.D224G	C21orf29_uc010gpv.1_Missense_Mutation_p.D156G	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	224					cell adhesion	extracellular region	structural molecule activity				0						TGGGGTGGCGTCTGAGCCCGG	0.677													C	45949800	C	C	45949800	3	2	152	1	0	0	0	0	1	0	0	0	2124	1667	58	4	1370	4	C21orf29	21	45949800	Missense_Mutation	SNP	T	TCGA-19-1390-01A-01D-1495-08	15000415	45949800	2180095	124	10617											
ACE2	59272	broad.mit.edu	37	chrX	15582159	15582159	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ccacttacttcttccgatctCtgatcccagtgaagatcagg	7	13	3	3			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:15582159C>T	uc004cxa.1	-	17	2465	c.2297G>A	c.(2296-2298)AGA>AAA	p.R766K	ACE2_uc004cxb.2_Missense_Mutation_p.R766K	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	766	Cytoplasmic (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	CTTCCGATCTCTGATCCCAGT	0.413													T	15582159	T	T	15582159	3	4	152	1	0	0	0	0	1	0	0	0	137	913	32	3	128	3	ACE2	23	15582159	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08		15582159	139688401	125	10618											
RS1	6247	broad.mit.edu	37	chrX	18690198	18690198	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcgtgacatcttcccctcGtcctcggccaaagctctacc	7	17	2	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:18690198G>A	uc004cyo.2	-	1	26	c.-9C>T	c.(-11--7)GACGA>GATGA			NM_000330	NP_000321	O15537	XLRS1_HUMAN	X-linked juvenile retinoschisis protein						cell adhesion|multicellular organismal development|response to stimulus|visual perception	extracellular space				ovary(2)	2	Hepatocellular(33;0.183)					TCTTCCCCTCGTCCTCGGCCA	0.443													A	18690198	A	A	18690198	1	1	152	1	0	0	0	0	0	0	0	0	13693	1160	40	1		1	RS1	23	18690198	Translation_Start_Site	SNP	G	TCGA-19-1390-01A-01D-1495-08	3108039	18690198	136580362	126	10619											
KLHL34	257240	broad.mit.edu	37	chrX	21674007	21674007	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atctagcgcctctccaacctCtccctccctctcgtcgtccc	4	22	4	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:21674007C>T	uc004czz.1	-	1	2442	c.1900G>A	c.(1900-1902)GAG>AAG	p.E634K		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	634										ovary(1)	1						TCTCCAACCTCTCCCTCCCTC	0.637													T	21674007	T	T	21674007	3	4	152	1	0	0	0	0	1	0	0	0	8387	922	32	3	38	3	KLHL34	23	21674007	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	2983809	21674007	133596553	127	10620											
BCOR	54880	broad.mit.edu	37	chrX	39932304	39932304	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgctagtttccaaaatctcGgaaaaccgattccggagggt	10	10	1	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:39932304G>A	uc004den.3	-	4	2587	c.2295C>T	c.(2293-2295)TCC>TCT	p.S765S	BCOR_uc004dep.3_Silent_p.S765S|BCOR_uc004deo.3_Silent_p.S765S|BCOR_uc004dem.3_Silent_p.S765S|BCOR_uc004deq.3_Silent_p.S765S	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	765					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CCAAAATCTCGGAAAACCGAT	0.512													A	39932304	A	A	39932304	2	1	152	1	0	0	0	0	0	0	0	1	1386	1103	39	2		2	BCOR	23	39932304	Silent	SNP	G	TCGA-19-1390-01A-01D-1495-08	18258297	39932304	115338256	128	10621											
BMP15	9210	broad.mit.edu	37	chrX	50653945	50653945	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctagaagaatcccctggCgaacagccaaggaagccccg	11	14	0	2	rs149633402		TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:50653945C>T	uc011mnw.1	+	1	162	c.162C>T	c.(160-162)GGC>GGT	p.G54G		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	54					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					AATCCCCTGGCGAACAGCCAA	0.592													T	50653945	T	T	50653945	2	4	152	1	0	0	0	0	0	0	0	1	1458	755	27	1		1	BMP15	23	50653945	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	10721641	50653945	104616615	129	10622											
KDM5C	8242	broad.mit.edu	37	chrX	53230914	53230914	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagtgctcaatgcactggcGcccagcaggcaactgtgggc	14	12	1	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:53230914G>A	uc004drz.2	-	14	2412	c.1879C>T	c.(1879-1881)CGC>TGC	p.R627C	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Missense_Mutation_p.R560C|KDM5C_uc004dsa.2_Missense_Mutation_p.R626C	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	627	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						ATGCACTGGCGCCCAGCAGGC	0.587			N|F|S		clear cell renal carcinoma								A	53230914	A	A	53230914	3	1	152	1	0	0	0	0	1	0	0	0	8135	1087	38	1	2953	1	KDM5C	23	53230914	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	2576969	53230914	102039646	130	10623											
FAM123B	139285	broad.mit.edu	37	chrX	63412206	63412206	+	Frame_Shift_Del	DEL	T	-	-													acctgtcaatgaatcaaagcTtttcagggatgtcacatccc							TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:63412206delT	uc004dvo.2	-	2	1234	c.961delA	c.(961-963)AGCfs	p.S321fs		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	321					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GAATCAAAGCTTTTCAGGGAT	0.522													-	63412206	-	-	63412206	7	5	152	1	0	1	0	1	0	0	0	0	5423	1609	56	0	2450	0	FAM123B	23	63412206	Frame_Shift_Del	DEL	T	TCGA-19-1390-01A-01D-1495-08	10181292	63412206	91858354	131	10624											
YIPF6	286451	broad.mit.edu	37	chrX	67731798	67731798	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttgacagctccacattaaaTgaatctgttcgcaataccat	5	10	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:67731798T>A	uc004dwy.2	+	2	188	c.165T>A	c.(163-165)AAT>AAA	p.N55K	YIPF6_uc011mph.1_Intron	NM_173834	NP_776195	Q96EC8	YIPF6_HUMAN	Yip1 domain family, member 6	55						endoplasmic reticulum|integral to membrane					0						CCACATTAAATGAATCTGTTC	0.393													A	67731798	A	A	67731798	3	1	152	1	0	0	0	0	1	0	0	0	17479	1461	51	5	171	5	YIPF6	23	67731798	Missense_Mutation	SNP	T	TCGA-19-1390-01A-01D-1495-08	4319592	67731798	87538762	132	10625											
PCDH11X	27328	broad.mit.edu	37	chrX	91133162	91133162	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	aaacaagaatcttacactttCtatgtaaaggctgaggatgg	9	6	2	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:91133162C>A	uc004efk.1	+	2	2768	c.1923C>A	c.(1921-1923)TTC>TTA	p.F641L	PCDH11X_uc004efl.1_Missense_Mutation_p.F641L|PCDH11X_uc004efo.1_Missense_Mutation_p.F641L|PCDH11X_uc010nmv.1_Missense_Mutation_p.F641L|PCDH11X_uc004efm.1_Missense_Mutation_p.F641L|PCDH11X_uc004efn.1_Missense_Mutation_p.F641L|PCDH11X_uc004efh.1_Missense_Mutation_p.F641L|PCDH11X_uc004efj.1_Missense_Mutation_p.F641L	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	641	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CTTACACTTTCTATGTAAAGG	0.363													A	91133162	A	A	91133162	3	1	152	1	0	0	0	0	1	0	0	0	11508	912	32	5	1929	5	PCDH11X	23	91133162	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	23401364	91133162	64137398	133	10626											
OCRL	4952	broad.mit.edu	37	chrX	128721074	128721074	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggcttctagtagatcacctAttcaaatacgcctgtcacca	6	12	4	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:128721074A>G	uc004euq.2	+	20	2400	c.2235A>G	c.(2233-2235)CTA>CTG	p.L745L	OCRL_uc004eur.2_Silent_p.L737L|OCRL_uc010nrb.2_5'Flank	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	745	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						TAGATCACCTATTCAAATACG	0.403													G	128721074	G	G	128721074	2	3	152	1	0	0	0	0	0	0	0	1	10823	436	16	4		4	OCRL	23	128721074	Silent	SNP	A	TCGA-19-1390-01A-01D-1495-08	37587912	128721074	26549486	134	10627											
HTATSF1	27336	broad.mit.edu	37	chrX	135593609	135593609	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaagagaatttgaagaaaatGgtctcgagaaagatttggac	11	3	1	5			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:135593609G>T	uc004ezw.2	+	10	2127	c.1705G>T	c.(1705-1707)GGT>TGT	p.G569C	HTATSF1_uc004ezx.2_Missense_Mutation_p.G569C	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	569	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TGAAGAAAATGGTCTCGAGAA	0.393													T	135593609	T	T	135593609	3	4	152	1	0	0	0	0	1	0	0	0	7433	1348	47	5	1739	5	HTATSF1	23	135593609	Missense_Mutation	SNP	G	TCGA-19-1390-01A-01D-1495-08	6872535	135593609	19676951	135	10628											
SOX3	6658	broad.mit.edu	37	chrX	139586804	139586804	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccatgaaggcgttcatgggcCgtttcacacggtcctggtct	12	12	3	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:139586804C>T	uc004fbd.1	-	1	422	c.422G>A	c.(421-423)CGG>CAG	p.R141Q		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	141	HMG box.				face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					GTTCATGGGCCGTTTCACACG	0.652													T	139586804	T	T	139586804	3	4	152	1	0	0	0	0	1	0	0	0	14951	652	23	2	922	2	SOX3	23	139586804	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	3993195	139586804	15683756	136	10629											
MTM1	4534	broad.mit.edu	37	chrX	149839946	149839946	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acatggagctcttagccttaCgcgacgaatacataaagcgg	10	10	1	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:149839946C>T	uc004fef.3	+	15	1766	c.1690C>T	c.(1690-1692)CGC>TGC	p.R564C	MTM1_uc011mxx.1_RNA|MTM1_uc011mxy.1_Missense_Mutation_p.R527C|MTM1_uc011mxz.1_Missense_Mutation_p.R449C|MTM1_uc010nte.2_Missense_Mutation_p.R432C	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	564					endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTTAGCCTTACGCGACGAATA	0.517													T	149839946	T	T	149839946	3	4	152	1	0	0	0	0	1	0	0	0	9937	536	19	1	1744	1	MTM1	23	149839946	Missense_Mutation	SNP	C	TCGA-19-1390-01A-01D-1495-08	10253142	149839946	5430614	137	10630											
GABRE	2564	broad.mit.edu	37	chrX	151128446	151128446	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catctcattctcaggataggAaactggaaaggaatgtgaga	11	6	2	1			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:151128446A>G	uc004ffi.2	-	6	703	c.649T>C	c.(649-651)TCC>CCC	p.S217P	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA|MIR224_hsa-mir-224|MI0000301_5'Flank|MIR452_hsa-mir-452|MI0001733_5'Flank	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	217	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGGATAGGAAACTGGAAAG	0.438													G	151128446	G	G	151128446	3	3	152	1	0	0	0	0	1	0	0	0	6170	246	9	4	887	4	GABRE	23	151128446	Missense_Mutation	SNP	A	TCGA-19-1390-01A-01D-1495-08	1288500	151128446	4142114	138	10631											
PLXNB3	5365	broad.mit.edu	37	chrX	153033712	153033712	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgccacgtaggattccccCgagtcgtacccctgtggcga	11	16	0	0			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:153033712C>T	uc004fii.2	+	4	1269	c.1095C>T	c.(1093-1095)CCC>CCT	p.P365P	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Silent_p.P47P|PLXNB3_uc010nuk.2_Silent_p.P388P|PLXNB3_uc011mzd.1_Silent_p.P4P	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	365	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGATTCCCCCGAGTCGTACC	0.687													T	153033712	T	T	153033712	2	4	152	1	0	0	0	0	0	0	0	1	12125	639	23	2		2	PLXNB3	23	153033712	Silent	SNP	C	TCGA-19-1390-01A-01D-1495-08	1905266	153033712	2236848	139	10632											
MPP1	4354	broad.mit.edu	37	chrX	154009984	154009984	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agctgccaaactccaagaacTcattggcagagatgttcctc	8	12	1	2			TCGA-19-1390-01A-01D-1495-08	TCGA-19-1390-10C-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	d7e8e408-0a8f-4177-ad38-08c5da484ed0	59e90d1d-d052-4486-ba3a-85698c0ca427	g.chrX:154009984T>A	uc004fmp.1	-	10	1155	c.1040A>T	c.(1039-1041)GAG>GTG	p.E347V	MPP1_uc010nvg.1_Missense_Mutation_p.E327V|MPP1_uc011mzv.1_Missense_Mutation_p.E317V|MPP1_uc004fmq.1_Missense_Mutation_p.E301V|MPP1_uc011mzw.1_Missense_Mutation_p.E330V	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	347	Guanylate kinase-like.|Interaction with MPP5.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTCCAAGAACTCATTGGCAGA	0.468													A	154009984	A	A	154009984	3	1	152	1	0	0	0	0	1	0	0	0	9733	1551	54	5	372	5	MPP1	23	154009984	Missense_Mutation	SNP	T	TCGA-19-1390-01A-01D-1495-08	976272	154009984	1260576	140	10633											
MTOR	2475	broad.mit.edu	37	chr1	11190804	11190804	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttgtagtgtagcacagcttCgaagttcatcactgcccacg	9	11	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:11190804C>T	uc001asd.2	-	39	5516	c.5395G>A	c.(5395-5397)GAA>AAA	p.E1799K	MTOR_uc001asc.2_Missense_Mutation_p.E4K	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1799	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						AGCACAGCTTCGAAGTTCATC	0.493													T	11190804	T	T	11190804	3	4	153	1	0	0	0	0	1	0	0	0	9954	893	31	2	2334	2	MTOR	1	11190804	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08		11190804	238059817	1	10634											
PRAMEF12	390999	broad.mit.edu	37	chr1	12837525	12837525	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctaagcctggagctgtatcCtgcccctctggagagttatg	12	11	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:12837525C>T	uc001aui.2	+	3	1262	c.1235C>T	c.(1234-1236)CCT>CTT	p.P412L		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	412										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCTGTATCCTGCCCCTCTG	0.577													T	12837525	T	T	12837525	3	4	153	1	0	0	0	0	1	0	0	0	12428	681	24	3	1245	3	PRAMEF12	1	12837525	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	1646721	12837525	236413096	2	10635											
DDI2	84301	broad.mit.edu	37	chr1	15978327	15978327	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggctggaagagaggatgtaCggccagaggagattgcagac	18	6	0	4			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:15978327C>A	uc001awx.1	+	8	1216	c.1120C>A	c.(1120-1122)CGG>AGG	p.R374R	DDI2_uc009voj.1_Silent_p.R115R	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	374					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		AGAGGATGTACGGCCAGAGGA	0.512													A	15978327	A	A	15978327	2	1	153	1	0	0	0	0	0	0	0	1	4329	527	19	5		5	DDI2	1	15978327	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	3140802	15978327	233272294	3	10636											
C1orf64	149563	broad.mit.edu	37	chr1	16330879	16330879	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acaggcctggagaccagctcCggtaagaggcggcaaaggga	16	10	0	2	rs143498880	byFrequency	TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:16330879C>A	uc001axn.2	+	1	149	c.81C>A	c.(79-81)TCC>TCA	p.S27S		NM_178840	NP_849162	Q8NEQ6	CA064_HUMAN	hypothetical protein LOC149563	27										breast(2)	2		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		AGACCAGCTCCGGTAAGAGGC	0.483													A	16330879	A	A	16330879	2	1	153	1	0	0	0	0	0	0	0	1	2054	666	23	5		5	C1orf64	1	16330879	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	352552	16330879	232919742	4	10637											
CDA	978	broad.mit.edu	37	chr1	20945033	20945033	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgctgccctcctcctttgGgcctgaggacctgcagaaga	12	14	0	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:20945033G>A	uc001bdk.2	+	4	592	c.413G>A	c.(412-414)GGG>GAG	p.G138E	CDA_uc001bdl.2_RNA|CDA_uc009vpv.2_RNA	NM_001785	NP_001776	P32320	CDD_HUMAN	cytidine deaminase	138					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	TCCTCCTTTGGGCCTGAGGAC	0.542													A	20945033	A	A	20945033	3	1	153	1	0	0	0	0	1	0	0	0	3052	1232	43	3	427	3	CDA	1	20945033	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	4614154	20945033	228305588	5	10638											
HSPG2	3339	broad.mit.edu	37	chr1	22163397	22163397	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgggcacagcacagtggaacTcaacgctggccccaatgctc	11	14	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:22163397T>A	uc001bfj.2	-	75	10293	c.10253A>T	c.(10252-10254)GAG>GTG	p.E3418V	HSPG2_uc009vqd.2_Missense_Mutation_p.E3419V	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3418	Ig-like C2-type 20.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	ACAGTGGAACTCAACGCTGGC	0.662													A	22163397	A	A	22163397	3	1	153	1	0	0	0	0	1	0	0	0	7430	1551	54	5	3014	5	HSPG2	1	22163397	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	1218364	22163397	227087224	6	10639											
ARID1A	8289	broad.mit.edu	37	chr1	27099916	27099916	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctacagtcgtgctgccggCcctgggctaggaaatgtggc	14	13	0	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:27099916C>T	uc001bmv.1	+	15	4168	c.3795C>T	c.(3793-3795)GGC>GGT	p.G1265G	ARID1A_uc001bmt.1_Silent_p.G1264G|ARID1A_uc001bmu.1_Silent_p.G1265G|ARID1A_uc001bmw.1_Silent_p.G882G|ARID1A_uc001bmx.1_Silent_p.G111G|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1265					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GTGCTGCCGGCCCTGGGCTAG	0.607			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								T	27099916	T	T	27099916	2	4	153	1	0	0	0	0	0	0	0	1	913	726	26	3		3	ARID1A	1	27099916	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	4936519	27099916	222150705	7	10640											
CYP4X1	260293	broad.mit.edu	37	chr1	47498946	47498946	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctctagacggacccaagtGgttccagcatcgtcgcctac	11	14	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:47498946G>A	uc001cqt.2	+	4	648	c.398G>A	c.(397-399)TGG>TAG	p.W133*	CYP4X1_uc001cqr.2_Nonsense_Mutation_p.W132*|CYP4X1_uc001cqs.2_Nonsense_Mutation_p.W68*	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	133						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						GGACCCAAGTGGTTCCAGCAT	0.423													A	47498946	A	A	47498946	4	1	153	1	0	0	0	0	0	1	0	0	4193	1357	47	3	412	3	CYP4X1	1	47498946	Nonsense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	20399030	47498946	201751675	8	10641											
SYDE2	84144	broad.mit.edu	37	chr1	85624724	85624724	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcttttgtatttaaaaagtaGttttccccacagctgctcca	5	10	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:85624724G>C	uc009wcm.2	-	7	3343	c.3294C>G	c.(3292-3294)AAC>AAG	p.N1098K		NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	1098					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		TTAAAAAGTAGTTTTCCCCAC	0.388													C	85624724	C	C	85624724	3	2	153	1	0	0	0	0	1	0	0	0	15433	1020	36	5	294	5	SYDE2	1	85624724	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	38125778	85624724	163625897	9	10642											
COL24A1	255631	broad.mit.edu	37	chr1	86377068	86377068	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcttaaaaaattaccttttCgccaatgcttccagtcatcc	3	12	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:86377068C>T	uc001dlj.2	-	25	2653	c.2611G>A	c.(2611-2613)GAA>AAA	p.E871K	COL24A1_uc001dli.2_Missense_Mutation_p.E7K|COL24A1_uc010osd.1_Missense_Mutation_p.E171K|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	871	Collagen-like 6.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATTACCTTTTCGCCAATGCTT	0.308													T	86377068	T	T	86377068	3	4	153	1	0	0	0	0	1	0	0	0	3683	893	31	2	2677	2	COL24A1	1	86377068	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	752344	86377068	162873553	10	10643											
NOTCH2	4853	broad.mit.edu	37	chr1	120510201	120510201	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcacagtggaaggcgccatcCgtgttcacacattttcctgc	9	13	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:120510201C>A	uc001eik.2	-	8	1564	c.1308G>T	c.(1306-1308)ACG>ACT	p.T436T	NOTCH2_uc001eil.2_Silent_p.T436T|NOTCH2_uc001eim.3_Silent_p.T353T	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	436	Extracellular (Potential).|EGF-like 11; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGGCGCCATCCGTGTTCACAC	0.473			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				A	120510201	A	A	120510201	2	1	153	1	0	0	0	0	0	0	0	1	10548	639	23	5		5	NOTCH2	1	120510201	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	34133133	120510201	128740420	11	10644											
TCHH	7062	broad.mit.edu	37	chr1	152080460	152080460	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctaggatttttctgtagcGttcttggcggcgcagctgct	12	10	3	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:152080460G>A	uc001ezp.2	-	2	5233	c.5233C>T	c.(5233-5235)CGC>TGC	p.R1745C	TCHH_uc009wne.1_Missense_Mutation_p.R1745C	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1745	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTCTGTAGCGTTCTTGGCGG	0.587													A	152080460	A	A	152080460	3	1	153	1	0	0	0	0	1	0	0	0	15697	1145	40	1	602	1	TCHH	1	152080460	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	31570259	152080460	97170161	12	10645											
C1orf14	81626	broad.mit.edu	37	chr1	182922239	182922239	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggtgcggaatgagtccgcGggcaccgaggccttggagcc	17	11	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:182922239G>A	uc001gpu.2	-	1	315	c.30C>T	c.(28-30)CCC>CCT	p.P10P	C1orf14_uc001gpv.2_5'UTR|C1orf14_uc010pnz.1_5'UTR|C1orf14_uc001gpw.2_5'UTR	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	82											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		ATGAGTCCGCGGGCACCGAGG	0.716													A	182922239	A	A	182922239	2	1	153	1	0	0	0	0	0	0	0	1	2000	1103	39	2		2	C1orf14	1	182922239	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	30841779	182922239	66328382	13	10646											
PPP1R12B	4660	broad.mit.edu	37	chr1	202418229	202418229	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcttcctagcactgccaatGgggttacagctactcctgtg	9	13	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:202418229G>A	uc001gya.1	+	13	1924	c.1780G>A	c.(1780-1782)GGG>AGG	p.G594R	PPP1R12B_uc001gxz.1_Missense_Mutation_p.G594R	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	594					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			CACTGCCAATGGGGTTACAGC	0.507													A	202418229	A	A	202418229	3	1	153	1	0	0	0	0	1	0	0	0	12355	1348	47	3	1920	3	PPP1R12B	1	202418229	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	19495990	202418229	46832392	14	10647											
OR2B11	127623	broad.mit.edu	37	chr1	247614696	247614696	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtatggtgtcattcacagCggtgtcagcacacgacagct	11	11	3	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr1:247614696C>T	uc010pyx.1	-	1	589	c.589G>A	c.(589-591)GCT>ACT	p.A197T		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	197	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TCATTCACAGCGGTGTCAGCA	0.577													T	247614696	T	T	247614696	3	4	153	1	0	0	0	0	1	0	0	0	10988	768	27	1	367	1	OR2B11	1	247614696	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	45196467	247614696	1635925	15	10648											
CIB4	130106	broad.mit.edu	37	chr2	26805768	26805768	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgttgtcattgtccagatccGactcactcaggacctggcga	10	12	3	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:26805768G>A	uc002rhm.2	-	6	481	c.452C>T	c.(451-453)TCG>TTG	p.S151L		NM_001029881	NP_001025052	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	151	EF-hand 3.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCCAGATCCGACTCACTCAG	0.542													A	26805768	A	A	26805768	3	1	153	1	0	0	0	0	1	0	0	0	3423	1059	37	2	113	2	CIB4	2	26805768	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08		26805768	216393605	16	10649											
CAD	790	broad.mit.edu	37	chr2	27465508	27465508	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atcacgatggtgggtgacctGaagcacggacgcacagtaca	13	10	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:27465508G>T	uc002rji.2	+	41	6405	c.6243G>T	c.(6241-6243)CTG>CTT	p.L2081L	CAD_uc010eyw.2_Silent_p.L2018L	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	2081	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TGGGTGACCTGAAGCACGGAC	0.587													T	27465508	T	T	27465508	2	4	153	1	0	0	0	0	0	0	0	1	2565	1277	45	5		5	CAD	2	27465508	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	659740	27465508	215733865	17	10650											
BIRC6	57448	broad.mit.edu	37	chr2	32710744	32710744	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctagaagttggacttgaacaGcaagcagaactgatgttgaa	11	6	0	5			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:32710744G>A	uc010ezu.2	+	40	7865	c.7731G>A	c.(7729-7731)CAG>CAA	p.Q2577Q		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2577					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GACTTGAACAGCAAGCAGAAC	0.373													A	32710744	A	A	32710744	2	1	153	1	0	0	0	0	0	0	0	1	1438	962	34	3		3	BIRC6	2	32710744	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	5245236	32710744	210488629	18	10651											
PRKCE	5581	broad.mit.edu	37	chr2	46228662	46228662	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttaccccagacaaaatcaccAacagcggccagagaaggaaa	8	12	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:46228662A>G	uc002rut.2	+	7	1140	c.943A>G	c.(943-945)AAC>GAC	p.N315D		NM_005400	NP_005391	Q02156	KPCE_HUMAN	protein kinase C, epsilon	315					activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity			lung(4)|ovary(3)|kidney(1)|breast(1)|large_intestine(1)	10		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CAAAATCACCAACAGCGGCCA	0.552													G	46228662	G	G	46228662	3	3	153	1	0	0	0	0	1	0	0	0	12511	130	5	4	969	4	PRKCE	2	46228662	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08	13517918	46228662	196970711	19	10652											
RAB11FIP5	26056	broad.mit.edu	37	chr2	73316179	73316179	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgttgcggaggaagaagccTttggctttgcccatcttgcc	12	10	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:73316179T>C	uc002siu.3	-	2	937	c.696A>G	c.(694-696)AAA>AAG	p.K232K	RAB11FIP5_uc002sit.3_Silent_p.K154K	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	232					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GGAAGAAGCCTTTGGCTTTGC	0.602													C	73316179	C	C	73316179	2	2	153	1	0	0	0	0	0	0	0	1	12897	1606	56	4		4	RAB11FIP5	2	73316179	Silent	SNP	T	TCGA-19-1790-01B-01D-1353-08	27087517	73316179	169883194	20	10653											
PAX8	7849	broad.mit.edu	37	chr2	113999249	113999249	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccgtgcgaaggtgctttcggGgtccgctgctgctgctctgt	15	12	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:113999249G>T	uc010yxt.1	-	7	822	c.656C>A	c.(655-657)CCC>CAC	p.P219H	PAX8_uc010yxu.1_Missense_Mutation_p.P219H|PAX8_uc010yxv.1_Missense_Mutation_p.P219H|PAX8_uc002tjm.2_Missense_Mutation_p.P219H|PAX8_uc002tjn.2_Missense_Mutation_p.P219H|PAX8_uc010fku.1_Missense_Mutation_p.P219H|LOC654433_uc002tjq.3_Intron|LOC654433_uc010fks.2_Intron|LOC654433_uc010fkt.2_Intron|LOC654433_uc002tjr.3_Intron	NM_003466	NP_003457	Q06710	PAX8_HUMAN	paired box 8 isoform PAX8A	219					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity			ovary(1)|lung(1)	2						GTGCTTTCGGGGTCCGCTGCT	0.597			T	PPARG	follicular thyroid		Thyroid dysgenesis 						T	113999249	T	T	113999249	3	4	153	1	0	0	0	0	1	0	0	0	11485	1232	43	5	595	5	PAX8	2	113999249	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	40683070	113999249	129200124	21	10654											
TTN	7273	broad.mit.edu	37	chr2	179407009	179407009	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	acggatgctgctgcgacactCtatgacctcagactgcaagt	10	12	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:179407009C>G	uc010zfg.1	-	298	89994	c.89770G>C	c.(89770-89772)GAG>CAG	p.E29924Q	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E23619Q|TTN_uc010zfi.1_Missense_Mutation_p.E23552Q|TTN_uc010zfj.1_Missense_Mutation_p.E23427Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30851							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCGACACTCTATGACCTCA	0.463													G	179407009	G	G	179407009	3	3	153	1	0	0	0	0	1	0	0	0	16732	922	32	5	10561	5	TTN	2	179407009	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	65407760	179407009	63792364	22	10655											
TTN	7273	broad.mit.edu	37	chr2	179634616	179634616	+	Frame_Shift_Del	DEL	T	-	-													ctcacactcaaaagaggcagTtttggtctcaggcacctcga					rs78680811		TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:179634616delT	uc010zfg.1	-	37	8916	c.8692delA	c.(8692-8694)ACTfs	p.T2898fs	TTN_uc010zfh.1_Frame_Shift_Del_p.T2852fs|TTN_uc010zfi.1_Frame_Shift_Del_p.T2852fs|TTN_uc010zfj.1_Frame_Shift_Del_p.T2852fs|TTN_uc002unb.2_Frame_Shift_Del_p.T2898fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2898							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAGAGGCAGTTTTGGTCTCA	0.368													-	179634616	-	-	179634616	7	5	153	1	0	1	0	1	0	0	0	0	16732	1725	60	0	102600	0	TTN	2	179634616	Frame_Shift_Del	DEL	T	TCGA-19-1790-01B-01D-1353-08	227607	179634616	63564757	23	10656											
MYO1B	4430	broad.mit.edu	37	chr2	192255148	192255148	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctacgccttcaggcaggccTatgaaccttgcctagaaaga	10	12	1	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:192255148T>C	uc010fsg.2	+	18	2167	c.1912T>C	c.(1912-1914)TAT>CAT	p.Y638H	MYO1B_uc002usq.2_Missense_Mutation_p.Y638H|MYO1B_uc002usr.2_Missense_Mutation_p.Y638H|MYO1B_uc002usu.2_5'Flank	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	638	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			CAGGCAGGCCTATGAACCTTG	0.468													C	192255148	C	C	192255148	3	2	153	1	0	0	0	0	1	0	0	0	10069	1522	53	4	1978	4	MYO1B	2	192255148	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	12620532	192255148	50944225	24	10657											
TMEFF2	23671	broad.mit.edu	37	chr2	193049126	193049126	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acaagtatctcactctgctgTttgcatgcagcctgtcgcag	9	12	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:193049126T>C	uc002utc.2	-	3	760	c.366A>G	c.(364-366)AAA>AAG	p.K122K	TMEFF2_uc002utd.1_Silent_p.K122K	NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	122	Kazal-like 1.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			CACTCTGCTGTTTGCATGCAG	0.473													C	193049126	C	C	193049126	2	2	153	1	0	0	0	0	0	0	0	1	16011	1722	60	4		4	TMEFF2	2	193049126	Silent	SNP	T	TCGA-19-1790-01B-01D-1353-08	793978	193049126	50150247	25	10658											
PAX3	5077	broad.mit.edu	37	chr2	223096854	223096854	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agttcctccctagtataaatGtcagggtaatgagttctctc	8	9	2	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:223096854G>C	uc010fwo.2	-	5	1101	c.735C>G	c.(733-735)GAC>GAG	p.D245E	PAX3_uc002vmt.1_Missense_Mutation_p.D245E|PAX3_uc002vmy.1_Missense_Mutation_p.D244E|PAX3_uc002vmv.1_Missense_Mutation_p.D245E|PAX3_uc002vmw.1_Missense_Mutation_p.D245E|PAX3_uc002vmx.1_Missense_Mutation_p.D245E	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	245	Homeobox.				apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAGTATAAATGTCAGGGTAAT	0.527			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						C	223096854	C	C	223096854	3	2	153	1	0	0	0	0	1	0	0	0	11480	1368	48	5	834	5	PAX3	2	223096854	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	30047728	223096854	20102519	26	10659											
ESPNL	339768	broad.mit.edu	37	chr2	239036280	239036280	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cagccatgtccctcagcccgGcctggcctggccatcctgac	10	19	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:239036280G>C	uc002vxq.3	+	7	1230	c.1120G>C	c.(1120-1122)GCC>CCC	p.A374P	ESPNL_uc010fyw.2_Missense_Mutation_p.A70P	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	374	Pro-rich.									pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CCTCAGCCCGGCCTGGCCTGG	0.672													C	239036280	C	C	239036280	3	2	153	1	0	0	0	0	1	0	0	0	5255	1203	42	5	1146	5	ESPNL	2	239036280	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	15939426	239036280	4163093	27	10660											
OR6B3	150681	broad.mit.edu	37	chr2	240985270	240985270	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgggggtgatgtcagacaCgtaccagatctctaggaaag	13	8	2	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:240985270C>T	uc010zoe.1	-	1	220	c.220G>A	c.(220-222)GTG>ATG	p.V74M	PRR21_uc010zod.1_5'Flank	NM_173351	NP_775486	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		ATGTCAGACACGTACCAGATC	0.557													T	240985270	T	T	240985270	3	4	153	1	0	0	0	0	1	0	0	0	11189	536	19	1	778	1	OR6B3	2	240985270	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	1948990	240985270	2214103	28	10661											
MYEOV2	150678	broad.mit.edu	37	chr2	241066064	241066064	+	Frame_Shift_Del	DEL	T	-	-													gtttcatcactcttaaaacaTttacccctccagtgagtaga							TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:241066064delT	uc002vyu.1	-	5	675	c.675delA	c.(673-675)AAAfs	p.K225fs		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		TCTTAAAACATTTACCCCTCC	0.488													-	241066064	-	-	241066064	7	5	153	1	0	1	0	1	0	0	0	0	10026	1490	52	0	87	0	MYEOV2	2	241066064	Frame_Shift_Del	DEL	T	TCGA-19-1790-01B-01D-1353-08	80794	241066064	2133309	29	10662											
MYEOV2	150678	broad.mit.edu	37	chr2	241069334	241069334	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgcacttcttacctcttcCgacaccacaggccgctctgc	7	17	3	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:241069334C>T	uc002vyu.1	-	4	375	c.375G>A	c.(373-375)TCG>TCA	p.S125S		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		TTACCTCTTCCGACACCACAG	0.617													T	241069334	T	T	241069334	2	4	153	1	0	0	0	0	0	0	0	1	10026	639	23	2		2	MYEOV2	2	241069334	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	3270	241069334	2130039	30	10663											
D2HGDH	728294	broad.mit.edu	37	chr2	242683078	242683078	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgcgtcctggaggagctgAgccggtatgtggaggaacgg	19	8	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr2:242683078A>G	uc002wce.1	+	5	705	c.532A>G	c.(532-534)AGC>GGC	p.S178G	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Missense_Mutation_p.S44G|D2HGDH_uc002wcg.1_RNA	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	178	FAD-binding PCMH-type.				2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GGAGGAGCTGAGCCGGTATGT	0.642													G	242683078	G	G	242683078	3	3	153	1	0	0	0	0	1	0	0	0	4213	304	11	4	546	4	D2HGDH	2	242683078	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08	1613744	242683078	516295	31	10664											
DNAH1	25981	broad.mit.edu	37	chr3	52393305	52393305	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaactggcctggccaggtgaCcatcgctgggtgccagacct	14	13	0	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr3:52393305C>G	uc011bef.1	+	26	4571	c.4310C>G	c.(4309-4311)ACC>AGC	p.T1437S		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1437	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGCCAGGTGACCATCGCTGGG	0.627													G	52393305	G	G	52393305	3	3	153	1	0	0	0	0	1	0	0	0	4597	507	18	5	4408	5	DNAH1	3	52393305	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08		52393305	145629125	32	10665											
OR5K2	402135	broad.mit.edu	37	chr3	98216751	98216751	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggattcttgctgtgcctgtgCtattacccccaaaatgttag	9	10	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr3:98216751C>G	uc011bgx.1	+	1	227	c.227C>G	c.(226-228)GCT>GGT	p.A76G		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	76	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TGTGCCTGTGCTATTACCCCC	0.413													G	98216751	G	G	98216751	3	3	153	1	0	0	0	0	1	0	0	0	11167	797	28	5	229	5	OR5K2	3	98216751	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	45823446	98216751	99805679	33	10666											
PPP2R3A	5523	broad.mit.edu	37	chr3	135721607	135721607	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atattgaagaagagtcagatGgaaagaaagcattagataaa	10	2	1	6			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr3:135721607G>T	uc003eqv.1	+	2	1832	c.1267G>T	c.(1267-1269)GGA>TGA	p.G423*	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	423					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						AGAGTCAGATGGAAAGAAAGC	0.358													T	135721607	T	T	135721607	4	4	153	1	0	0	0	0	0	1	0	0	12388	1349	47	5	1269	5	PPP2R3A	3	135721607	Nonsense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	37504856	135721607	62300823	34	10667											
ACPL2	92370	broad.mit.edu	37	chr3	141006223	141006223	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aaggatccggagcctctttcGaaagccccttgaactccttg	9	13	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr3:141006223G>T	uc003etu.2	+	7	732	c.433G>T	c.(433-435)GAA>TAA	p.E145*	ACPL2_uc003etv.2_Nonsense_Mutation_p.E145*|ACPL2_uc011bna.1_Nonsense_Mutation_p.E107*|ACPL2_uc011bnb.1_Nonsense_Mutation_p.E128*	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	145						extracellular region	acid phosphatase activity			skin(1)	1						AGCCTCTTTCGAAAGCCCCTT	0.493													T	141006223	T	T	141006223	4	4	153	1	0	0	0	0	0	1	0	0	166	1059	37	5	447	5	ACPL2	3	141006223	Nonsense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	5284616	141006223	57016207	35	10668											
PLCH1	23007	broad.mit.edu	37	chr3	155198910	155198910	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cggccttcaaggccacccccTttcgtgttcttcaggtagcc	9	16	3	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr3:155198910T>A	uc011bok.1	-	23	5206	c.4929A>T	c.(4927-4929)AAA>AAT	p.K1643N	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.K1605N	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1643					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGCCACCCCCTTTCGTGTTCT	0.562													A	155198910	A	A	155198910	3	1	153	1	0	0	0	0	1	0	0	0	12037	1606	56	5	156	5	PLCH1	3	155198910	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	14192687	155198910	42823520	36	10669											
MECOM	2122	broad.mit.edu	37	chr3	168834168	168834168	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggaggcctgtggtacaagcCggaaggaaacagaccaggga	16	8	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr3:168834168C>T	uc003ffi.3	-	7	1197	c.928G>A	c.(928-930)GGC>AGC	p.G310S	MECOM_uc010hwk.1_Missense_Mutation_p.G333S|MECOM_uc003ffj.3_Missense_Mutation_p.G375S|MECOM_uc011bpi.1_Missense_Mutation_p.G311S|MECOM_uc003ffn.3_Missense_Mutation_p.G310S|MECOM_uc003ffk.2_Missense_Mutation_p.G310S|MECOM_uc003ffl.2_Missense_Mutation_p.G470S|MECOM_uc011bpj.1_Missense_Mutation_p.G498S|MECOM_uc011bpk.1_Missense_Mutation_p.G300S|MECOM_uc010hwn.2_Missense_Mutation_p.G498S	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	310					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TGGTACAAGCCGGAAGGAAAC	0.473													T	168834168	T	T	168834168	3	4	153	1	0	0	0	0	1	0	0	0	9422	652	23	2	2267	2	MECOM	3	168834168	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	13635258	168834168	29188262	37	10670											
PIK3CA	5290	broad.mit.edu	37	chr3	178928108	178928127	+	Splice_Site	DEL	TGGATCAAATCCAAATAAAG	-	-													ctgaaccctattggtgttacTggatcaaatccaaataaagt							TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr3:178928108_178928127delTGGATCAAATCCAAATAAAG	uc003fjk.2	+	8	1561	c.1404_splice	c.e8+1	p.K468_splice		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTGGTGTTACTGGATCAAATCCAAATAAAGTAAGGTTTTT	0.332		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			-	178928127	-	-	178928108	8	5	153	1	0	1	0	1	0	0	1	0	11913	1567	55	0	1412	0	PIK3CA	3	178928108	Splice_Site	DEL	TGGATCAAATCCAAATAAAG	TCGA-19-1790-01B-01D-1353-08	10093940	178928108	19094322	38	10671											
HRG	3273	broad.mit.edu	37	chr3	186394875	186394875	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtgtaccgcctcatttgggaCatcccttccactggggtggg	13	12	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr3:186394875C>A	uc003fqq.2	+	7	804	c.781C>A	c.(781-783)CAT>AAT	p.H261N		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	261					fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		TCATTTGGGACATCCCTTCCA	0.468													A	186394875	A	A	186394875	3	1	153	1	0	0	0	0	1	0	0	0	7354	478	17	5	807	5	HRG	3	186394875	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	7466767	186394875	11627555	39	10672											
TNK2	10188	broad.mit.edu	37	chr3	195611779	195611779	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cgcaggtccttctccccaatGaggcaggtgaggctctgcag	13	13	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr3:195611779G>C	uc003fvu.1	-	4	903	c.360C>G	c.(358-360)CTC>CTG	p.L120L	TNK2_uc003fvs.1_Silent_p.L152L|TNK2_uc003fvt.1_Silent_p.L183L|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_5'UTR|TNK2_uc010hzx.1_Silent_p.L134L	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	120					positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	TCTCCCCAATGAGGCAGGTGA	0.672													C	195611779	C	C	195611779	2	2	153	1	0	0	0	0	0	0	0	1	16315	1277	45	5		5	TNK2	3	195611779	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	9216904	195611779	2410651	40	10673											
FGFR3	2261	broad.mit.edu	37	chr4	1807639	1807639	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgcctaccaggtggcccGgggcatggagtacttggcct	15	12	0	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr4:1807639G>A	uc003gdr.3	+	13	2064	c.1808G>A	c.(1807-1809)CGG>CAG	p.R603Q	FGFR3_uc003gdu.2_Missense_Mutation_p.R605Q|FGFR3_uc003gds.3_Missense_Mutation_p.R491Q|FGFR3_uc003gdq.3_Missense_Mutation_p.R604Q	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	603	Protein kinase.|Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CAGGTGGCCCGGGGCATGGAG	0.612		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				A	1807639	A	A	1807639	3	1	153	1	0	0	0	0	1	0	0	0	5867	1116	39	2	2009	2	FGFR3	4	1807639	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08		1807639	189346637	41	10674											
WHSC2	7469	broad.mit.edu	37	chr4	1986590	1986590	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgggaaccacgctgggcgtGgagggaaggtagctcgtgga	20	8	0	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr4:1986590G>A	uc003gem.2	-	8	1254	c.1014C>T	c.(1012-1014)TCC>TCT	p.S338S	WHSC2_uc003gek.2_Silent_p.S64S|WHSC2_uc003gel.2_Silent_p.S252S|WHSC2_uc003gen.2_Silent_p.S192S	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	327					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			CGCTGGGCGTGGAGGGAAGGT	0.617													A	1986590	A	A	1986590	2	1	153	1	0	0	0	0	0	0	0	1	17361	1335	47	3		3	WHSC2	4	1986590	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	178951	1986590	189167686	42	10675											
CC2D2A	57545	broad.mit.edu	37	chr4	15589458	15589458	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaatttcttgatctcctggCaggggatgaagaagaacatg	12	7	2	4			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr4:15589458C>T	uc010idv.2	+	33	4330	c.4085C>T	c.(4084-4086)GCA>GTA	p.A1362V	CC2D2A_uc003gnx.2_Missense_Mutation_p.A1254V|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	1362					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						GATCTCCTGGCAGGGGATGAA	0.383													T	15589458	T	T	15589458	3	4	153	1	0	0	0	0	1	0	0	0	2728	710	25	3	4410	3	CC2D2A	4	15589458	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	13602868	15589458	175564818	43	10676											
SLIT2	9353	broad.mit.edu	37	chr4	20598280	20598280	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gacgaacataacacttcaggTaagagatctctctctatgga	8	9	3	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr4:20598280T>A	uc003gpr.1	+	32	3765	c.3561_splice	c.e32+2	p.Q1187_splice	SLIT2_uc003gps.1_Splice_Site_p.Q1179_splice	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor						apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ACACTTCAGGTAAGAGATCTC	0.358													A	20598280	A	A	20598280	5	1	153	1	0	0	0	0	0	0	1	0	14740	1652	57	5	3689	5	SLIT2	4	20598280	Splice_Site	SNP	T	TCGA-19-1790-01B-01D-1353-08	5008822	20598280	170555996	44	10677											
EPHA5	2044	broad.mit.edu	37	chr4	66361196	66361196	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agcttcctcatgggtataacTgtgaggtggacatttgccgc	12	9	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr4:66361196T>A	uc003hcy.2	-	4	1169	c.976A>T	c.(976-978)AGT>TGT	p.S326C	EPHA5_uc003hcx.2_Missense_Mutation_p.S257C|EPHA5_uc003hcz.2_Missense_Mutation_p.S326C|EPHA5_uc011cah.1_Missense_Mutation_p.S326C|EPHA5_uc011cai.1_Missense_Mutation_p.S326C|EPHA5_uc003hda.2_Missense_Mutation_p.S326C	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	326	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TGGGTATAACTGTGAGGTGGA	0.463										TSP Lung(17;0.13)			A	66361196	A	A	66361196	3	1	153	1	0	0	0	0	1	0	0	0	5170	1580	55	5	2197	5	EPHA5	4	66361196	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	45762916	66361196	124793080	45	10678											
FGB	2244	broad.mit.edu	37	chr4	155490852	155490852	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaggaacagccggtaatgCcctcatggatggagcatctc	12	11	2	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr4:155490852C>T	uc003ioa.3	+	7	1184	c.1145C>T	c.(1144-1146)GCC>GTC	p.A382V	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.A320V|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.A163V	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	382	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GCCGGTAATGCCCTCATGGAT	0.473													T	155490852	T	T	155490852	3	4	153	1	0	0	0	0	1	0	0	0	5831	739	26	3	1171	3	FGB	4	155490852	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	89129656	155490852	35663424	46	10679											
PALLD	23022	broad.mit.edu	37	chr4	169824985	169824985	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caaagagatctcgatgggacCtgctccctccataccacagc	8	15	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr4:169824985C>A	uc011cjx.1	+	15	2761	c.2550C>A	c.(2548-2550)ACC>ACA	p.T850T	CBR4_uc011cjy.1_Intron|PALLD_uc003iru.2_Silent_p.T833T|PALLD_uc003irv.2_Silent_p.T451T|PALLD_uc003irw.2_Silent_p.T335T|PALLD_uc003irx.2_Silent_p.T59T	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	1057	Ig-like C2-type 3.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TCGATGGGACCTGCTCCCTCC	0.438									Pancreatic_Cancer_Familial_Clustering_of				A	169824985	A	A	169824985	2	1	153	1	0	0	0	0	0	0	0	1	11407	668	24	5		5	PALLD	4	169824985	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	14334133	169824985	21329291	47	10680											
ADAMTS16	170690	broad.mit.edu	37	chr5	5200249	5200249	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tctctctctctcatagctttGgcatgattcatgatggagaa	8	9	4	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr5:5200249G>T	uc003jdl.2	+	9	1456	c.1318G>T	c.(1318-1320)GGC>TGC	p.G440C	ADAMTS16_uc003jdk.1_Missense_Mutation_p.G440C|ADAMTS16_uc003jdj.1_Missense_Mutation_p.G440C	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	440	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						tcATAGCTTTGGCATGATTCA	0.388													T	5200249	T	T	5200249	3	4	153	1	0	0	0	0	1	0	0	0	261	1348	47	5	1352	5	ADAMTS16	5	5200249	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08		5200249	175715011	48	10681											
CDH18	1016	broad.mit.edu	37	chr5	19503108	19503108	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tatatatgttcaccttcattGtccttcagagtgaagtttgg	8	7	3	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr5:19503108G>C	uc003jgc.2	-	10	2000	c.1623C>G	c.(1621-1623)GAC>GAG	p.D541E	CDH18_uc003jgd.2_Missense_Mutation_p.D541E|CDH18_uc011cnm.1_Missense_Mutation_p.D541E	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	541	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CACCTTCATTGTCCTTCAGAG	0.353													C	19503108	C	C	19503108	3	2	153	1	0	0	0	0	1	0	0	0	3103	1368	48	5	761	5	CDH18	5	19503108	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	14302859	19503108	161412152	49	10682											
PRDM9	56979	broad.mit.edu	37	chr5	23522791	23522791	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ggccccctacatttgtaaagGacagtgcagtggacaagggg	14	9	0	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr5:23522791G>T	uc003jgo.2	+	8	861	c.679G>T	c.(679-681)GAC>TAC	p.D227Y		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	227					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATTTGTAAAGGACAGTGCAGT	0.552										HNSCC(3;0.000094)			T	23522791	T	T	23522791	3	4	153	1	0	0	0	0	1	0	0	0	12463	1174	41	5	705	5	PRDM9	5	23522791	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	4019683	23522791	157392469	50	10683											
NIPBL	25836	broad.mit.edu	37	chr5	37064646	37064646	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagtcattgagaaggtcaaaAcgaaattcagactctacgga	9	7	4	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr5:37064646A>G	uc003jkl.3	+	47	8566	c.8067A>G	c.(8065-8067)AAA>AAG	p.K2689K	NIPBL_uc003jkk.3_3'UTR|NIPBL_uc003jkn.2_3'UTR	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2689					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GAAGGTCAAAACGAAATTCAG	0.378													G	37064646	G	G	37064646	2	3	153	1	0	0	0	0	0	0	0	1	10428	40	2	4		4	NIPBL	5	37064646	Silent	SNP	A	TCGA-19-1790-01B-01D-1353-08	13541855	37064646	143850614	51	10684											
C9	735	broad.mit.edu	37	chr5	39288825	39288825	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcaaataaattgtcctcacCttcagaaattttttgtttac	3	8	3	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr5:39288825C>A	uc003jlv.3	-	10	1734	c.1645G>T	c.(1645-1647)GGA>TGA	p.G549*		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	549					complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			TTGTCCTCACCTTCAGAAATT	0.333													A	39288825	A	A	39288825	4	1	153	1	0	0	0	0	0	1	0	0	2443	695	24	5	42	5	C9	5	39288825	Nonsense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	2224179	39288825	141626435	52	10685											
C5orf35	133383	broad.mit.edu	37	chr5	56207282	56207282	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgttgcccaagcaactAgctcattgatttctgctgga	9	10	3	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr5:56207282A>G	uc003jqx.2	+	2	758	c.385A>G	c.(385-387)AGC>GGC	p.S129G	C5orf35_uc003jqy.2_Intron	NM_153706	NP_714917	Q8NE22	CE035_HUMAN	hypothetical protein LOC133383	129										ovary(1)	1		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.173)		OV - Ovarian serous cystadenocarcinoma(10;2.58e-39)		CCAAGCAACTAGCTCATTGAT	0.403													G	56207282	G	G	56207282	3	3	153	1	0	0	0	0	1	0	0	0	2294	420	15	4	391	4	C5orf35	5	56207282	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08	16918457	56207282	124707978	53	10686											
MTX3	345778	broad.mit.edu	37	chr5	79279592	79279592	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttccgaggaggaagctgaGggctttggcgaagattgtca	16	6	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr5:79279592G>A	uc010jag.2	-	9	881	c.854C>T	c.(853-855)CCT>CTT	p.P285L	MTX3_uc010jah.2_3'UTR|MTX3_uc003kge.3_Missense_Mutation_p.P224L	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	285					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		AGGAAGCTGAGGGCTTTGGCG	0.463													A	79279592	A	A	79279592	3	1	153	1	0	0	0	0	1	0	0	0	9969	1000	35	3	88	3	MTX3	5	79279592	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	23072310	79279592	101635668	54	10687											
SLC23A1	9963	broad.mit.edu	37	chr5	138716553	138716553	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggaaccagaaatgcaaaggCactggcctggaacagcggca	13	10	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr5:138716553C>A	uc003leh.2	-	4	428	c.331G>T	c.(331-333)GCC>TCC	p.A111S	SLC23A1_uc003leg.2_Missense_Mutation_p.A111S	NM_005847	NP_005838	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (nucleobase	111	Helical; (Potential).				brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	AATGCAAAGGCACTGGCCTGG	0.602													A	138716553	A	A	138716553	3	1	153	1	0	0	0	0	1	0	0	0	14462	710	25	5	1521	5	SLC23A1	5	138716553	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	59436961	138716553	42198707	55	10688											
KIF4B	285643	broad.mit.edu	37	chr5	154396908	154396908	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tttaaccctgtctgtgccacCcccaatagcaagatcctgaa	6	14	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr5:154396908C>A	uc010jih.1	+	1	3649	c.3489C>A	c.(3487-3489)ACC>ACA	p.T1163T		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1163	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCTGTGCCACCCCCAATAGCA	0.532													A	154396908	A	A	154396908	2	1	153	1	0	0	0	0	0	0	0	1	8304	610	22	5		5	KIF4B	5	154396908	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	15680355	154396908	26518352	56	10689											
C6orf146	222826	broad.mit.edu	37	chr6	4068936	4068938	+	In_Frame_Del	DEL	TTG	-	-													atgaaagaaaagagttatttTtgttcaatgggtgagcagca							TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:4068936_4068938delTTG	uc003mvx.2	-	7	1859_1861	c.1519_1521delCAA	c.(1519-1521)CAAdel	p.Q507del	C6orf146_uc010jnq.1_Intron|C6orf146_uc003mvy.2_In_Frame_Del_p.Q444del	NM_173563	NP_775834	Q8IXS0	CF146_HUMAN	hypothetical protein LOC222826	507										ovary(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				AGAGTTATTTTTGTTCAATGGGT	0.36													-	4068938	-	-	4068936	7	5	153	1	0	1	0	1	0	0	0	0	2335	1838	64	0	9	0	C6orf146	6	4068936	In_Frame_Del	DEL	TTG	TCGA-19-1790-01B-01D-1353-08		4068936	167046131	57	10690											
CFB	629	broad.mit.edu	37	chr6	31915244	31915244	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttaccctgcgtggctcccagCggcgaacgtgtcaggaaggt	14	12	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:31915244C>T	uc003nyj.3	+	4	882	c.604C>T	c.(604-606)CGG>TGG	p.R202W	CFB_uc011dor.1_Missense_Mutation_p.R704W|CFB_uc003nyi.2_Missense_Mutation_p.R202W	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	202	Sushi 3.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						TGGCTCCCAGCGGCGAACGTG	0.632													T	31915244	T	T	31915244	3	4	153	1	0	0	0	0	1	0	0	0	3278	759	27	1	618	1	CFB	6	31915244	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	27846308	31915244	139199823	58	10691											
TAP2	6891	broad.mit.edu	37	chr6	32806007	32806007	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtctcaggtcagggagccGcatggctctgtcaacggata	15	10	4	0	rs61736918		TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:32806007G>A	uc003occ.2	-	1	35	c.4C>T	c.(4-6)CGG>TGG	p.R2W	TAP2_uc011dqf.1_Missense_Mutation_p.R2W|TAP2_uc003ocb.1_Missense_Mutation_p.R2W|TAP2_uc003ocd.2_Missense_Mutation_p.R2W	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	2	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						TCAGGGAGCCGCATGGCTCTG	0.622													A	32806007	A	A	32806007	3	1	153	1	0	0	0	0	1	0	0	0	15548	1086	38	1	2185	1	TAP2	6	32806007	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	890763	32806007	138309060	59	10692											
LEMD2	221496	broad.mit.edu	37	chr6	33740529	33740529	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	aggccaggaactccacagctCggtcccagacacgcttcatg	10	15	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:33740529C>A	uc011drm.1	-	9	1401	c.1388G>T	c.(1387-1389)CGA>CTA	p.R463L	LEMD2_uc010jvg.2_Missense_Mutation_p.R172L|LEMD2_uc011drl.1_Missense_Mutation_p.R161L|LEMD2_uc003ofe.2_Missense_Mutation_p.R161L	NM_181336	NP_851853	Q8NC56	LEMD2_HUMAN	LEM domain containing 2 isoform 1	463						integral to nuclear inner membrane				central_nervous_system(1)	1						CTCCACAGCTCGGTCCCAGAC	0.627													A	33740529	A	A	33740529	3	1	153	1	0	0	0	0	1	0	0	0	8720	884	31	5	127	5	LEMD2	6	33740529	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	934522	33740529	137374538	60	10693											
PGK2	5232	broad.mit.edu	37	chr6	49754282	49754282	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	accaagtatagccagaaaggGtctcactgggttttccaagg	11	9	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:49754282G>T	uc003ozu.2	-	1	726	c.619C>A	c.(619-621)CCC>ACC	p.P207T		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	207					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					GCCAGAAAGGGTCTCACTGGG	0.428													T	49754282	T	T	49754282	3	4	153	1	0	0	0	0	1	0	0	0	11791	1261	44	5	638	5	PGK2	6	49754282	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	16013753	49754282	121360785	61	10694											
GOPC	57120	broad.mit.edu	37	chr6	117892118	117892118	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tttctttagggaatcttgatCcttattgggaggaaaaaaga	10	4	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:117892118C>A	uc003pxu.2	-	6	1047	c.817G>T	c.(817-819)GAT>TAT	p.D273Y	GOPC_uc003pxq.1_Missense_Mutation_p.D46Y|GOPC_uc003pxv.2_Missense_Mutation_p.D265Y	NM_020399	NP_065132	Q9HD26	GOPC_HUMAN	golgi associated PDZ and coiled-coil motif	273					apical protein localization|cytoplasmic sequestering of CFTR protein|ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein homooligomerization|protein transport	cell junction|dendrite|Golgi membrane|postsynaptic density|postsynaptic membrane|trans-Golgi network transport vesicle	cystic fibrosis transmembrane conductance regulator binding			ovary(1)	1		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		GAATCTTGATCCTTATTGGGA	0.328			O	ROS1	glioblastoma								A	117892118	A	A	117892118	3	1	153	1	0	0	0	0	1	0	0	0	6573	869	30	5	587	5	GOPC	6	117892118	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	68137836	117892118	53222949	62	10695											
UTRN	7402	broad.mit.edu	37	chr6	145103130	145103130	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaccaaaatgaccagctccTcagtgttccagatgtcatca	7	12	3	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:145103130T>C	uc003qkt.2	+	60	8797	c.8705T>C	c.(8704-8706)CTC>CCC	p.L2902P		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2902	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GACCAGCTCCTCAGTGTTCCA	0.403													C	145103130	C	C	145103130	3	2	153	1	0	0	0	0	1	0	0	0	17100	1551	54	4	8943	4	UTRN	6	145103130	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	27211012	145103130	26011937	63	10696											
ESR1	2099	broad.mit.edu	37	chr6	152163775	152163775	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agggtggcagagaaagattgGccagtaccaatgacaaggga	15	6	0	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:152163775G>T	uc003qom.3	+	4	866	c.496G>T	c.(496-498)GCC>TCC	p.A166S	ESR1_uc010kin.2_Missense_Mutation_p.A166S|ESR1_uc010kio.2_Missense_Mutation_p.A166S|ESR1_uc010kip.2_Missense_Mutation_p.A166S|ESR1_uc003qon.3_Missense_Mutation_p.A166S|ESR1_uc003qoo.3_Missense_Mutation_p.A166S|ESR1_uc010kiq.2_Intron|ESR1_uc010kir.2_Intron|ESR1_uc011eet.1_RNA|ESR1_uc011eeu.1_RNA|ESR1_uc011eev.1_5'UTR|ESR1_uc011eew.1_5'UTR	NM_001122742	NP_001116214	P03372	ESR1_HUMAN	estrogen receptor alpha isoform 4	166	Modulating; mediates interaction with MACROD1.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	AGAAAGATTGGCCAGTACCAA	0.453													T	152163775	T	T	152163775	3	4	153	1	0	0	0	0	1	0	0	0	5256	1203	42	5	502	5	ESR1	6	152163775	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	7060645	152163775	18951292	64	10697											
TIAM2	26230	broad.mit.edu	37	chr6	155451173	155451173	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tccttcctggcccccggcatGcctgaccccagtctccatgc	8	20	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:155451173G>T	uc003qqb.2	+	6	2089	c.816G>T	c.(814-816)ATG>ATT	p.M272I	TIAM2_uc003qqe.2_Missense_Mutation_p.M272I	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	272					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCCCCGGCATGCCTGACCCCA	0.597													T	155451173	T	T	155451173	3	4	153	1	0	0	0	0	1	0	0	0	15888	1319	46	5	818	5	TIAM2	6	155451173	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	3287398	155451173	15663894	65	10698											
IGF2R	3482	broad.mit.edu	37	chr6	160445736	160445736	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcaatgtttgtagagacataGgtatgaatctttgtggggct	12	4	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr6:160445736G>T	uc003qta.2	+	5	794	c.646G>T	c.(646-648)GAC>TAC	p.D216Y		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	216	2.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TAGAGACATAGGTATGAATCT	0.438													T	160445736	T	T	160445736	3	4	153	1	0	0	0	0	1	0	0	0	7576	1014	35	5	664	5	IGF2R	6	160445736	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	4994563	160445736	10669331	66	10699											
KIAA0415	9907	broad.mit.edu	37	chr7	4830771	4830771	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctttattgctgtcaaagatgAggaccctggctcacagtcca	9	11	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:4830771A>G	uc003sne.2	+	17	2262	c.2179A>G	c.(2179-2181)AGG>GGG	p.R727G	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Missense_Mutation_p.R204G	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	727					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		GTCAAAGATGAGGACCCTGGC	0.637													G	4830771	G	G	4830771	3	3	153	1	0	0	0	0	1	0	0	0	8175	295	11	4	2245	4	KIAA0415	7	4830771	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08		4830771	154307892	67	10700											
STARD3NL	83930	broad.mit.edu	37	chr7	38254036	38254039	+	Splice_Site	DEL	GTAA	-	-													cttcatattttgatatatttGtaagtattttttatgtttca							TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:38254036_38254039delGTAA	uc003tfr.2	+	3	451	c.303_splice	c.e3+1	p.F101_splice	STARD3NL_uc003tfs.2_Splice_Site_p.F101_splice|STARD3NL_uc003tft.2_Splice_Site_p.F101_splice	NM_032016	NP_114405	O95772	MENTO_HUMAN	MLN64 N-terminal homolog							integral to membrane|late endosome membrane				ovary(1)	1						TGATATATTTGTAAGTATTTTTTA	0.338													-	38254039	-	-	38254036	8	5	153	1	0	1	0	1	0	0	1	0	15257	1391	48	0	310	0	STARD3NL	7	38254036	Splice_Site	DEL	GTAA	TCGA-19-1790-01B-01D-1353-08	33423265	38254036	120884627	68	10701											
AMPH	273	broad.mit.edu	37	chr7	38516553	38516553	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtccactagcttcctgctgCgcttggcgatgcgattctgt	11	12	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:38516553C>T	uc003tgu.2	-	6	482	c.413G>A	c.(412-414)CGC>CAC	p.R138H	AMPH_uc003tgv.2_Missense_Mutation_p.R138H	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	138	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CTTCCTGCTGCGCTTGGCGAT	0.502													T	38516553	T	T	38516553	3	4	153	1	0	0	0	0	1	0	0	0	588	768	27	1	1738	1	AMPH	7	38516553	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	262517	38516553	120622110	69	10702											
C7orf25	79020	broad.mit.edu	37	chr7	42949845	42949845	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aactctggtcacctgcaaaaGttcagggccctcatcatctg	8	13	6	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:42949845G>C	uc003thw.2	-	2	1119	c.655C>G	c.(655-657)CTT>GTT	p.L219V	C7orf25_uc010kxq.2_Missense_Mutation_p.L219V|C7orf25_uc003thx.3_Missense_Mutation_p.L277V|C7orf25_uc010kxr.2_Missense_Mutation_p.L277V	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	219										skin(1)	1						ACCTGCAAAAGTTCAGGGCCC	0.438													C	42949845	C	C	42949845	3	2	153	1	0	0	0	0	1	0	0	0	2380	1029	36	5	614	5	C7orf25	7	42949845	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	4433292	42949845	116188818	70	10703											
ADCY1	107	broad.mit.edu	37	chr7	45632382	45632382	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgccaatgccttgctcttcGtcggtgtgaacatgtatggg	13	9	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:45632382G>A	uc003tne.3	+	2	682	c.664G>A	c.(664-666)GTC>ATC	p.V222I	ADCY1_uc003tnd.2_5'UTR	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	222	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CTTGCTCTTCGTCGGTGTGAA	0.592													A	45632382	A	A	45632382	3	1	153	1	0	0	0	0	1	0	0	0	292	1145	40	1	670	1	ADCY1	7	45632382	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	2682537	45632382	113506281	71	10704											
TNS3	64759	broad.mit.edu	37	chr7	47408183	47408183	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccagggtgggcgagcctgggGaggggcctgtgctcagctct	19	11	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:47408183G>A	uc003tnv.2	-	17	2427	c.2060C>T	c.(2059-2061)TCC>TTC	p.S687F	TNS3_uc003tnw.2_Missense_Mutation_p.S687F	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	687						focal adhesion	protein binding			ovary(4)	4						CGAGCCTGGGGAGGGGCCTGT	0.622													A	47408183	A	A	47408183	3	1	153	1	0	0	0	0	1	0	0	0	16341	1174	41	3	2337	3	TNS3	7	47408183	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	1775801	47408183	111730480	72	10705											
POM121L12	285877	broad.mit.edu	37	chr7	53103674	53103674	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggaggcgccctgcccttcccGgggagaccgctctggggcga	17	15	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:53103674G>C	uc003tpz.2	+	1	326	c.310G>C	c.(310-312)GGG>CGG	p.G104R		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	104											0						TGCCCTTCCCGGGGAGACCGC	0.721													C	53103674	C	C	53103674	3	2	153	1	0	0	0	0	1	0	0	0	12241	1116	39	5	312	5	POM121L12	7	53103674	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	5695491	53103674	106034989	73	10706											
EGFR	1956	broad.mit.edu	37	chr7	55249121	55249121	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	actatgtccgggaacacaaaGacaatattggctcccagtac	8	11	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:55249121G>C	uc003tqk.2	+	20	2665	c.2419G>C	c.(2419-2421)GAC>CAC	p.D807H	EGFR_uc010kzg.1_Missense_Mutation_p.D762H|EGFR_uc011kco.1_Missense_Mutation_p.D754H|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	807	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.D807N(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGAACACAAAGACAATATTGG	0.582		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			C	55249121	C	C	55249121	3	2	153	1	0	0	0	0	1	0	0	0	4967	942	33	5	2761	5	EGFR	7	55249121	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	2145447	55249121	103889542	74	10707											
RSBN1L	222194	broad.mit.edu	37	chr7	77402516	77402516	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacctcgaacaagtgagcccCgtgagatgctctttgaagac	10	11	1	4			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:77402516C>T	uc010ldt.1	+	6	1722	c.1678C>T	c.(1678-1680)CGT>TGT	p.R560C	RSBN1L_uc003ugm.2_Missense_Mutation_p.R342C	NM_198467	NP_940869	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	560						nucleus				ovary(1)	1						AAGTGAGCCCCGTGAGATGCT	0.383													T	77402516	T	T	77402516	3	4	153	1	0	0	0	0	1	0	0	0	13697	652	23	2	1700	2	RSBN1L	7	77402516	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	22153395	77402516	81736147	75	10708											
AKAP9	10142	broad.mit.edu	37	chr7	91668077	91668078	+	Frame_Shift_Ins	INS	-	GA	GA													aagataaaacatttatagttINSagacagtctgtaagtatgcc							TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:91668077_91668078insGA	uc003ulg.2	+	17	4908_4909	c.4683_4684insGA	c.(4681-4686)GTTAGAfs	p.V1561fs	AKAP9_uc003ule.2_Frame_Shift_Ins_p.V1573fs|AKAP9_uc003ulf.2_Frame_Shift_Ins_p.V1561fs|AKAP9_uc003uli.2_Frame_Shift_Ins_p.V1186fs	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1573_1574					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CATTTATAGTTAGACAGTCTGT	0.287			T	BRAF	papillary thyroid								GA	91668078	GA	GA	91668077	7	5	153	1	0	1	1	0	0	0	0	0	459	1741	61	0	4749	0	AKAP9	7	91668077	Frame_Shift_Ins	INS	-	TCGA-19-1790-01B-01D-1353-08	14265561	91668077	67470586	76	10709											
ZAN	7455	broad.mit.edu	37	chr7	100350019	100350019	+	Frame_Shift_Del	DEL	A	-	-													aaaacccaccacccccacagAaaaacccaccatctccccag							TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:100350019delA	uc003uwj.2	+	14	2456	c.2291delA	c.(2290-2292)GAAfs	p.E764fs	ZAN_uc003uwk.2_Frame_Shift_Del_p.E764fs|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	764	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACCCCCACAGAAAAACCCACC	0.527													-	100350019	-	-	100350019	7	5	153	1	0	1	0	1	0	0	0	0	17510	246	9	0	2341	0	ZAN	7	100350019	Frame_Shift_Del	DEL	A	TCGA-19-1790-01B-01D-1353-08	8681942	100350019	58788644	77	10710											
MUC17	140453	broad.mit.edu	37	chr7	100674925	100674925	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggtacaacatctacaaatgtCgtggagccaagaatgtattt	9	7	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:100674925C>T	uc003uxp.1	+	3	281	c.228C>T	c.(226-228)GTC>GTT	p.V76V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	76	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTACAAATGTCGTGGAGCCAA	0.453													T	100674925	T	T	100674925	2	4	153	1	0	0	0	0	0	0	0	1	9974	871	31	2		2	MUC17	7	100674925	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	324906	100674925	58463738	78	10711											
PPP1R3A	5506	broad.mit.edu	37	chr7	113558410	113558410	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttgaccaaaatgtaccaacAgaagtttcataacgtataca	5	8	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:113558410A>C	uc010ljy.1	-	1	673	c.642T>G	c.(640-642)TCT>TCG	p.S214S		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	214	CBM21.				glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ATGTACCAACAGAAGTTTCAT	0.353													C	113558410	C	C	113558410	2	2	153	1	0	0	0	0	0	0	0	1	12371	175	7	5		5	PPP1R3A	7	113558410	Silent	SNP	A	TCGA-19-1790-01B-01D-1353-08	12883485	113558410	45580253	79	10712											
CALD1	800	broad.mit.edu	37	chr7	134552504	134552504	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catggatgattttgagcgtcGcagagaacttagaaggcaaa	12	6	0	4	rs142583902		TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:134552504G>A	uc003vrz.2	+	3	479	c.20G>A	c.(19-21)CGC>CAC	p.R7H	CALD1_uc003vry.2_Missense_Mutation_p.R7H|CALD1_uc003vsa.2_Missense_Mutation_p.R7H|CALD1_uc003vsb.2_Missense_Mutation_p.R7H|CALD1_uc010lmm.2_Missense_Mutation_p.R7H|CALD1_uc011kpt.1_5'UTR	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	7					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						TTTGAGCGTCGCAGAGAACTT	0.433													A	134552504	A	A	134552504	3	1	153	1	0	0	0	0	1	0	0	0	2581	1087	38	1	22	1	CALD1	7	134552504	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	20994094	134552504	24586159	80	10713											
NUP205	23165	broad.mit.edu	37	chr7	135311087	135311087	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgccaagtctatgacatgCgcccagaaacggacccgcag	10	13	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:135311087C>T	uc003vsw.2	+	33	4802	c.4771C>T	c.(4771-4773)CGC>TGC	p.R1591C	NUP205_uc003vsx.2_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1591					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						CTATGACATGCGCCCAGAAAC	0.423													T	135311087	T	T	135311087	3	4	153	1	0	0	0	0	1	0	0	0	10759	768	27	1	4901	1	NUP205	7	135311087	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	758583	135311087	23827576	81	10714											
FAM115A	9747	broad.mit.edu	37	chr7	143573699	143573699	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaggcagcagagggagtcgcCatggctctattggtttctgc	14	9	2	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr7:143573699C>A	uc003wdo.1	-	2	136	c.3G>T	c.(1-3)ATG>ATT	p.M1I	FAM115A_uc011ktu.1_Intron|FAM115A_uc003wdp.1_Missense_Mutation_p.M1I	NM_014719	NP_055534	Q9Y4C2	F115A_HUMAN	hypothetical protein LOC9747	1											0	Melanoma(164;0.0903)					AGGGAGTCGCCATGGCTCTAT	0.473													A	143573699	A	A	143573699	3	1	153	1	0	0	0	0	1	0	0	0	5405	594	21	5	2794	5	FAM115A	7	143573699	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	8262612	143573699	15564964	82	10715											
ANK1	286	broad.mit.edu	37	chr8	41530099	41530099	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatctgaatccactgtgtcGtcctccacaagttccagaga	8	13	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr8:41530099G>A	uc003xok.2	-	38	4953	c.4869C>T	c.(4867-4869)GAC>GAT	p.D1623D	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Silent_p.D1623D|ANK1_uc003xoj.2_Silent_p.D1623D|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Silent_p.D1664D	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1623	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCACTGTGTCGTCCTCCACAA	0.562													A	41530099	A	A	41530099	2	1	153	1	0	0	0	0	0	0	0	1	620	1136	40	1		1	ANK1	8	41530099	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08		41530099	104833923	83	10716											
TRHR	7201	broad.mit.edu	37	chr8	110131345	110131345	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgccctacaggactctagtGgttgtcaactcatttctctc	7	12	4	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr8:110131345G>A	uc003ymz.3	+	2	874	c.858G>A	c.(856-858)GTG>GTA	p.V286V		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	286	Helical; Name=6; (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GGACTCTAGTGGTTGTCAACT	0.418													A	110131345	A	A	110131345	2	1	153	1	0	0	0	0	0	0	0	1	16477	1335	47	3		3	TRHR	8	110131345	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	68601246	110131345	36232677	84	10717											
TRPS1	7227	broad.mit.edu	37	chr8	116599737	116599737	+	Frame_Shift_Del	DEL	C	-	-													ggctgtagtgatgtcctgttCctggcagtgaacagtgttga							TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr8:116599737delC	uc003ynz.2	-	4	2611	c.2152delG	c.(2152-2154)GAAfs	p.E718fs	TRPS1_uc011lhy.1_Frame_Shift_Del_p.E722fs|TRPS1_uc003yny.2_Frame_Shift_Del_p.E731fs|TRPS1_uc010mcy.2_Frame_Shift_Del_p.E718fs	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	718	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			ATGTCCTGTTCCTGGCAGTGA	0.507									Langer-Giedion_syndrome				-	116599737	-	-	116599737	7	5	153	1	0	1	0	1	0	0	0	0	16590	864	30	0	1705	0	TRPS1	8	116599737	Frame_Shift_Del	DEL	C	TCGA-19-1790-01B-01D-1353-08	6468392	116599737	29764285	85	10718											
TRPS1	7227	broad.mit.edu	37	chr8	116632180	116632180	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	catctgatctgcagaaaattCtttgttctttccagatacct	5	10	4	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr8:116632180C>T	uc003ynz.2	-	2	565	c.106G>A	c.(106-108)GAA>AAA	p.E36K	TRPS1_uc011lhy.1_Missense_Mutation_p.E40K|TRPS1_uc003yny.2_Missense_Mutation_p.E49K|TRPS1_uc010mcy.2_Missense_Mutation_p.E36K	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	36					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GCAGAAAATTCTTTGTTCTTT	0.448									Langer-Giedion_syndrome				T	116632180	T	T	116632180	3	4	153	1	0	0	0	0	1	0	0	0	16590	922	32	3	3759	3	TRPS1	8	116632180	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	32443	116632180	29731842	86	10719											
COMMD5	28991	broad.mit.edu	37	chr8	146076337	146076337	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccgctggctcccaaatacCacgctggccaagtccccgac	10	18	0	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr8:146076337C>T	uc003zem.2	-	2	518	c.387G>A	c.(385-387)GTG>GTA	p.V129V	COMMD5_uc003zel.1_RNA|COMMD5_uc003zen.2_Silent_p.V129V|COMMD5_uc003zeo.3_Silent_p.V129V|COMMD5_uc010mgf.2_Silent_p.V129V	NM_001081004	NP_001074473	Q9GZQ3	COMD5_HUMAN	COMM domain containing 5	129						nucleus	protein binding			ovary(1)	1	all_cancers(97;1.14e-11)|all_epithelial(106;7.74e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)			TCCCAAATACCACGCTGGCCA	0.652													T	146076337	T	T	146076337	2	4	153	1	0	0	0	0	0	0	0	1	3719	581	21	3		3	COMMD5	8	146076337	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	29444157	146076337	287685	87	10720											
PIGO	84720	broad.mit.edu	37	chr9	35095288	35095288	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gtagggagacaggaggctctCtaggcacgtgtgaatgctgg	17	7	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr9:35095288C>A	uc003zwd.2	-	2	671	c.275G>T	c.(274-276)AGA>ATA	p.R92I	PIGO_uc003zwc.1_Missense_Mutation_p.R92I|PIGO_uc003zwe.2_Missense_Mutation_p.R92I|PIGO_uc003zwf.2_Missense_Mutation_p.R92I|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	92					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGGAGGCTCTCTAGGCACGTG	0.582													A	35095288	A	A	35095288	3	1	153	1	0	0	0	0	1	0	0	0	11894	913	32	5	3034	5	PIGO	9	35095288	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08		35095288	106118143	88	10721											
OR2K2	26248	broad.mit.edu	37	chr9	114090010	114090010	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caccacaggtagaaaaagccTtgtttcttccctctgctgag	8	12	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr9:114090010T>C	uc011lwp.1	-	1	704	c.704A>G	c.(703-705)AAG>AGG	p.K235R		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	264	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGAAAAAGCCTTGTTTCTTCC	0.423													C	114090010	C	C	114090010	3	2	153	1	0	0	0	0	1	0	0	0	11005	1609	56	4	249	4	OR2K2	9	114090010	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	78994722	114090010	27123421	89	10722											
STXBP1	6812	broad.mit.edu	37	chr9	130422360	130422360	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccgccgactgctaaatacCgggctgcacacgtcttcttc	8	16	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr9:130422360C>T	uc004brl.2	+	5	495	c.298C>T	c.(298-300)CGG>TGG	p.R100W	STXBP1_uc004brk.2_Missense_Mutation_p.R100W	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	100					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						TGCTAAATACCGGGCTGCACA	0.527													T	130422360	T	T	130422360	3	4	153	1	0	0	0	0	1	0	0	0	15351	643	23	2	316	2	STXBP1	9	130422360	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	16332350	130422360	10791071	90	10723											
ITGB1	3688	broad.mit.edu	37	chr10	33211272	33211272	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttagggatcaagtttttcagCtcctgcaattaaaagataaa	7	6	2	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:33211272C>A	uc001iws.3	-	9	1177	c.1041G>T	c.(1039-1041)GAG>GAT	p.E347D	ITGB1_uc001iwp.3_Missense_Mutation_p.E347D|ITGB1_uc001iwq.3_Missense_Mutation_p.E347D|ITGB1_uc001iwr.3_Missense_Mutation_p.E347D|ITGB1_uc001iwt.3_Missense_Mutation_p.E347D|ITGB1_uc001iwu.1_Missense_Mutation_p.E347D	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	347	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				AGTTTTTCAGCTCCTGCAATT	0.348													A	33211272	A	A	33211272	3	1	153	1	0	0	0	0	1	0	0	0	7890	796	28	5	1625	5	ITGB1	10	33211272	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08		33211272	102323475	91	10724											
ALOX5	240	broad.mit.edu	37	chr10	45936078	45936078	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cctgctgtgcaccccattttCaaggtacagccagctaccgc	8	16	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:45936078C>A	uc001jce.2	+	8	1281	c.1182C>A	c.(1180-1182)TTC>TTA	p.F394L	ALOX5_uc009xmt.2_Missense_Mutation_p.F394L|ALOX5_uc010qfg.1_Missense_Mutation_p.F394L	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	394	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	ACCCCATTTTCAAGGTACAGC	0.582													A	45936078	A	A	45936078	3	1	153	1	0	0	0	0	1	0	0	0	540	825	29	5	1212	5	ALOX5	10	45936078	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	12724806	45936078	89598669	92	10725											
CDH23	64072	broad.mit.edu	37	chr10	73405621	73405621	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgtttgaggtgtacttggtgGggaacaactcccaccacttc	11	10	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:73405621G>C	uc001jrx.3	+	12	1551	c.1174G>C	c.(1174-1176)GGG>CGG	p.G392R	CDH23_uc001jrw.3_Missense_Mutation_p.G392R|CDH23_uc001jry.2_Missense_Mutation_p.G8R|CDH23_uc001jrz.2_Missense_Mutation_p.G8R	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	392	Cadherin 4.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GTACTTGGTGGGGAACAACTC	0.572													C	73405621	C	C	73405621	3	2	153	1	0	0	0	0	1	0	0	0	3108	1232	43	5	1303	5	CDH23	10	73405621	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	27469543	73405621	62129126	93	10726											
SYNPO2L	79933	broad.mit.edu	37	chr10	75407262	75407262	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtggagtcttaggagtcatAgggggcggggtcttgggagc	21	5	3	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:75407262A>G	uc001jut.3	-	4	2300	c.2148T>C	c.(2146-2148)CCT>CCC	p.P716P	SYNPO2L_uc001jus.3_Silent_p.P492P	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	716	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					TAGGAGTCATAGGGGGCGGGG	0.617													G	75407262	G	G	75407262	2	3	153	1	0	0	0	0	0	0	0	1	15455	407	15	4		4	SYNPO2L	10	75407262	Silent	SNP	A	TCGA-19-1790-01B-01D-1353-08	2001641	75407262	60127485	94	10727											
ZMIZ1	57178	broad.mit.edu	37	chr10	81061939	81061939	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggactcctcaagaagcgcCtcctgcccgcagagcactgt	10	15	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:81061939C>T	uc001kaf.2	+	18	2667	c.2095C>T	c.(2095-2097)CTC>TTC	p.L699F	ZMIZ1_uc001kag.2_Missense_Mutation_p.L575F	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	699					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CAAGAAGCGCCTCCTGCCCGC	0.627													T	81061939	T	T	81061939	3	4	153	1	0	0	0	0	1	0	0	0	17693	681	24	3	2149	3	ZMIZ1	10	81061939	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	5654677	81061939	54472808	95	10728											
RPP30	10556	broad.mit.edu	37	chr10	92660375	92660375	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctacagtgaagaaacctcGgccatcagaaggagatgaag	11	9	2	5			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:92660375G>A	uc009xtx.2	+	11	781	c.746G>A	c.(745-747)CGG>CAG	p.R249Q	RPP30_uc001khd.2_Missense_Mutation_p.R249Q	NM_006413	NP_006404	P78346	RPP30_HUMAN	ribonuclease P/MRP 30kDa subunit isoform b	249					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0						AAGAAACCTCGGCCATCAGAA	0.423													A	92660375	A	A	92660375	3	1	153	1	0	0	0	0	1	0	0	0	13612	1116	39	2	788	2	RPP30	10	92660375	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	11598436	92660375	42874372	96	10729											
PDLIM1	9124	broad.mit.edu	37	chr10	96998437	96998437	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gaatcctgagggcttgttggGatcccctgaaatgaggaaaa	13	7	0	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:96998437G>C	uc001kkh.2	-	6	800	c.691C>G	c.(691-693)CCC>GCC	p.P231A	PDLIM1_uc001kki.2_Missense_Mutation_p.P231A|PDLIM1_uc009xuv.2_Intron|PDLIM1_uc001kkj.1_Missense_Mutation_p.P231A	NM_020992	NP_066272	O00151	PDLI1_HUMAN	PDZ and LIM domain 1	231					response to oxidative stress	cytoplasm|cytoskeleton	zinc ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GGCTTGTTGGGATCCCCTGAA	0.443													C	96998437	C	C	96998437	3	2	153	1	0	0	0	0	1	0	0	0	11679	1174	41	5	306	5	PDLIM1	10	96998437	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	4338062	96998437	38536310	97	10730											
DMBT1	1755	broad.mit.edu	37	chr10	124358594	124358594	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactgtggccatagtgaagaCgctggtgtcatctgctcagg	13	9	3	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:124358594C>T	uc001lgk.1	+	26	3367	c.3261C>T	c.(3259-3261)GAC>GAT	p.D1087D	DMBT1_uc001lgl.1_Silent_p.D1077D|DMBT1_uc001lgm.1_Silent_p.D588D|DMBT1_uc009xzz.1_Silent_p.D1087D|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Silent_p.D48D	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1087	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATAGTGAAGACGCTGGTGTCA	0.532													T	124358594	T	T	124358594	2	4	153	1	0	0	0	0	0	0	0	1	4577	535	19	1		1	DMBT1	10	124358594	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	27360157	124358594	11176153	98	10731											
DMBT1	1755	broad.mit.edu	37	chr10	124390740	124390740	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctctggcagtgccggaacCgaggctggttctcccacaac	11	15	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:124390740C>T	uc001lgk.1	+	46	6008	c.5902C>T	c.(5902-5904)CGA>TGA	p.R1968*	DMBT1_uc001lgl.1_Nonsense_Mutation_p.R1958*|DMBT1_uc001lgm.1_Nonsense_Mutation_p.R1340*|DMBT1_uc009xzz.1_Nonsense_Mutation_p.R1968*|DMBT1_uc010qtx.1_Nonsense_Mutation_p.R688*|DMBT1_uc009yab.1_Nonsense_Mutation_p.R671*|DMBT1_uc009yac.1_Nonsense_Mutation_p.R262*	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1968	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTGCCGGAACCGAGGCTGGTT	0.542													T	124390740	T	T	124390740	4	4	153	1	0	0	0	0	0	1	0	0	4577	644	23	2	6084	2	DMBT1	10	124390740	Nonsense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	32146	124390740	11144007	99	10732											
DOCK1	1793	broad.mit.edu	37	chr10	128830507	128830507	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccggcaagagcatgcagaGccttgggagctgcaccatta	12	12	0	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr10:128830507G>A	uc001ljt.2	+	18	1836	c.1772G>A	c.(1771-1773)AGC>AAC	p.S591N	DOCK1_uc010qun.1_Missense_Mutation_p.S612N	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	591	DHR-1.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		AGCATGCAGAGCCTTGGGAGC	0.562													A	128830507	A	A	128830507	3	1	153	1	0	0	0	0	1	0	0	0	4684	971	34	3	1842	3	DOCK1	10	128830507	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	4439767	128830507	6704240	100	10733											
ART5	116969	broad.mit.edu	37	chr11	3660908	3660908	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gttaaaatggctacaggtctGattatagctccagagagtca	10	7	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:3660908G>C	uc001lyb.1	-	2	1144	c.751C>G	c.(751-753)CAG>GAG	p.Q251E	ART5_uc001lyc.1_Missense_Mutation_p.Q251E|ART5_uc001lyd.2_Intron|ART5_uc009yea.2_Intron	NM_053017	NP_443750	Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5 precursor	251						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTACAGGTCTGATTATAGCTC	0.522													C	3660908	C	C	3660908	3	2	153	1	0	0	0	0	1	0	0	0	1000	1299	45	5	136	5	ART5	11	3660908	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08		3660908	131345608	101	10734											
HBE1	3046	broad.mit.edu	37	chr11	5290821	5290821	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttgccatgggccttgacctTggggttgcccaggatggcag	15	11	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:5290821T>C	uc001mal.1	-	2	431	c.178A>G	c.(178-180)AAG>GAG	p.K60E	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Missense_Mutation_p.K60E	NM_005330	NP_005321	P02100	HBE_HUMAN	epsilon globin	60					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCTTGACCTTGGGGTTGCCC	0.507													C	5290821	C	C	5290821	3	2	153	1	0	0	0	0	1	0	0	0	6980	1821	63	4	273	4	HBE1	11	5290821	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	1629913	5290821	129715695	102	10735											
OR52L1	338751	broad.mit.edu	37	chr11	6008078	6008078	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccctaccaggagaaaagaaGgctgggatagcctccagctt	11	11	0	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:6008078G>A	uc001mcd.2	-	1	138	c.83C>T	c.(82-84)CCT>CTT	p.P28L		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	28	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGAAAAGAAGGCTGGGATAG	0.468													A	6008078	A	A	6008078	3	1	153	1	0	0	0	0	1	0	0	0	11125	1000	35	3	910	3	OR52L1	11	6008078	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	717257	6008078	128998438	103	10736											
SLC1A2	6506	broad.mit.edu	37	chr11	35313908	35313908	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gagaaggggtttttcctggtCactacaaagtaaatcaaggg	12	6	2	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:35313908C>T	uc001mwd.2	-	7	1609	c.1017G>A	c.(1015-1017)GTG>GTA	p.V339V	SLC1A2_uc001mwe.2_Silent_p.V330V|SLC1A2_uc010rev.1_Silent_p.V339V	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	339	Helical; (Potential).				D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	TTTTCCTGGTCACTACAAAGT	0.478													T	35313908	T	T	35313908	2	4	153	1	0	0	0	0	0	0	0	1	14432	813	29	3		3	SLC1A2	11	35313908	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	29305830	35313908	99692608	104	10737											
CREB3L1	90993	broad.mit.edu	37	chr11	46321656	46321656	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagcacagctactccctgagCggcgactcagcgccccagag	12	16	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:46321656C>T	uc001ncf.2	+	2	708	c.273C>T	c.(271-273)AGC>AGT	p.S91S		NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	91	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		ACTCCCTGAGCGGCGACTCAG	0.607			T	FUS	myxofibrosarcoma								T	46321656	T	T	46321656	2	4	153	1	0	0	0	0	0	0	0	1	3856	767	27	1		1	CREB3L1	11	46321656	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	11007748	46321656	88684860	105	10738											
LRP4	4038	broad.mit.edu	37	chr11	46916320	46916320	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtactcagagcggtgtggcaGcacctgccggatgtcgatgc	15	11	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:46916320G>A	uc001ndn.3	-	12	1506	c.1360C>T	c.(1360-1362)CTG>TTG	p.L454L		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	454	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CGGTGTGGCAGCACCTGCCGG	0.567													A	46916320	A	A	46916320	2	1	153	1	0	0	0	0	0	0	0	1	8959	962	34	3		3	LRP4	11	46916320	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	594664	46916320	88090196	106	10739											
OR5D14	219436	broad.mit.edu	37	chr11	55563704	55563704	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cttcctatgttttcatttttGtgactgtactaaaaatccgt	5	8	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:55563704G>C	uc010rim.1	+	1	673	c.673G>C	c.(673-675)GTG>CTG	p.V225L		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TTTCATTTTTGTGACTGTACT	0.478													C	55563704	C	C	55563704	3	2	153	1	0	0	0	0	1	0	0	0	11155	1377	48	5	675	5	OR5D14	11	55563704	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	8647384	55563704	79442812	107	10740											
OR6Q1	219952	broad.mit.edu	37	chr11	57798590	57798590	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagtggtgggtttggaccacCgactacggagacccatgtat	13	9	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:57798590C>T	uc010rjz.1	+	1	166	c.166C>T	c.(166-168)CGA>TGA	p.R56*	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	56	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				TTTGGACCACCGACTACGGAG	0.478													T	57798590	T	T	57798590	4	4	153	1	0	0	0	0	0	1	0	0	11208	644	23	2	168	2	OR6Q1	11	57798590	Nonsense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	2234886	57798590	77207926	108	10741											
PLAC1L	219990	broad.mit.edu	37	chr11	59812205	59812205	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctttaccccaaggaatatagAtcatgaccctcaggaaatcc	6	12	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:59812205A>T	uc001nol.2	+	3	490	c.305A>T	c.(304-306)GAT>GTT	p.D102V		NM_173801	NP_776162	Q86WS3	PLACL_HUMAN	placenta-specific 1-like precursor	102						extracellular region				ovary(2)|skin(1)	3						AGGAATATAGATCATGACCCT	0.408													T	59812205	T	T	59812205	3	4	153	1	0	0	0	0	1	0	0	0	12013	333	12	5	315	5	PLAC1L	11	59812205	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08	2013615	59812205	75194311	109	10742											
AHNAK	79026	broad.mit.edu	37	chr11	62299512	62299512	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cccttctggttcctcaatgcTcacatcaggagcagtaacat	7	13	4	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:62299512T>A	uc001ntl.2	-	5	2677	c.2377A>T	c.(2377-2379)AGC>TGC	p.S793C	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	793					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCCTCAATGCTCACATCAGGA	0.502													A	62299512	A	A	62299512	3	1	153	1	0	0	0	0	1	0	0	0	414	1551	54	5	15415	5	AHNAK	11	62299512	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	2487307	62299512	72707004	110	10743											
DPP3	10072	broad.mit.edu	37	chr11	66252660	66252660	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaggcgttcctggtctatgCcgcgggtgtttactccaaca	11	12	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:66252660C>T	uc001oig.1	+	3	349	c.287C>T	c.(286-288)GCC>GTC	p.A96V	DPP3_uc001oif.1_Missense_Mutation_p.A96V|DPP3_uc010rpe.1_Intron	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	96					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						CTGGTCTATGCCGCGGGTGTT	0.592													T	66252660	T	T	66252660	3	4	153	1	0	0	0	0	1	0	0	0	4728	739	26	3	293	3	DPP3	11	66252660	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	3953148	66252660	68753856	111	10744											
MMP7	4316	broad.mit.edu	37	chr11	102395756	102395756	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcaaaggcatgagccagcGtgtttcctggcccatcaaat	11	12	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:102395756G>A	uc001phb.2	-	4	571	c.524C>T	c.(523-525)ACG>ATG	p.T175M	MMP7_uc009yxd.2_Missense_Mutation_p.T175M	NM_002423	NP_002414	P09237	MMP7_HUMAN	matrix metalloproteinase 7 preproprotein	175		Calcium 2; via carbonyl oxygen.			collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(1)	1	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		ATGAGCCAGCGTGTTTCCTGG	0.478													A	102395756	A	A	102395756	3	1	153	1	0	0	0	0	1	0	0	0	9667	1145	40	1	291	1	MMP7	11	102395756	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	36143096	102395756	32610760	112	10745											
PPP2R1B	5519	broad.mit.edu	37	chr11	111631562	111631562	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgtctgatttctgctttaaCagcatttgatgccctgggat	9	9	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:111631562C>G	uc001plx.1	-	4	604	c.520G>C	c.(520-522)GTT>CTT	p.V174L	PPP2R1B_uc001plw.1_Missense_Mutation_p.V174L|PPP2R1B_uc010rwi.1_Missense_Mutation_p.V110L|PPP2R1B_uc010rwj.1_Intron|PPP2R1B_uc010rwk.1_Missense_Mutation_p.V174L|PPP2R1B_uc010rwl.1_Intron	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	174	HEAT 5.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		TCTGCTTTAACAGCATTTGAT	0.438													G	111631562	G	G	111631562	3	3	153	1	0	0	0	0	1	0	0	0	12383	478	17	5	1556	5	PPP2R1B	11	111631562	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	9235806	111631562	23374954	113	10746											
OR8D1	283159	broad.mit.edu	37	chr11	124180313	124180313	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	catagcgatcatatgccatgGcagtcaggaggtaaccctca	10	11	3	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:124180313G>C	uc010sag.1	-	1	350	c.350C>G	c.(349-351)GCC>GGC	p.A117G		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		ATATGCCATGGCAGTCAGGAG	0.478													C	124180313	C	C	124180313	3	2	153	1	0	0	0	0	1	0	0	0	11231	1203	42	5	579	5	OR8D1	11	124180313	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	12548751	124180313	10826203	114	10747											
CCDC15	80071	broad.mit.edu	37	chr11	124910501	124910501	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcagcatatactcgggcacTacattcattcatcaattcct	5	12	3	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr11:124910501T>C	uc001qbm.3	+	16	3009	c.2750T>C	c.(2749-2751)CTA>CCA	p.L917P		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	917						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		ACTCGGGCACTACATTCATTC	0.393													C	124910501	C	C	124910501	3	2	153	1	0	0	0	0	1	0	0	0	2784	1522	53	4	2808	4	CCDC15	11	124910501	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	730188	124910501	10096015	115	10748											
VWF	7450	broad.mit.edu	37	chr12	6153612	6153612	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggccgacaggataggctccTtttgcctcgaaggtaggaaa	14	9	0	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr12:6153612T>C	uc001qnn.1	-	18	2537	c.2287A>G	c.(2287-2289)AGG>GGG	p.R763G	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	763					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GATAGGCTCCTTTTGCCTCGA	0.522													C	6153612	C	C	6153612	3	2	153	1	0	0	0	0	1	0	0	0	17243	1608	56	4	6294	4	VWF	12	6153612	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08		6153612	127698283	116	10749											
A2M	2	broad.mit.edu	37	chr12	9251275	9251275	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acagcacggagggcgcagacGgactgaggagccgctgtgac	17	11	0	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr12:9251275G>C	uc001qvk.1	-	15	1892	c.1779C>G	c.(1777-1779)TCC>TCG	p.S593S	A2M_uc009zgk.1_Silent_p.S443S	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	593					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GGGCGCAGACGGACTGAGGAG	0.582													C	9251275	C	C	9251275	2	2	153	1	0	0	0	0	0	0	0	1	4	1103	39	5		5	A2M	12	9251275	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	3097663	9251275	124600620	117	10750											
MLL2	8085	broad.mit.edu	37	chr12	49416568	49416568	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tactgagatgacttggagtgCacaaactgcttgctgtaggg	13	7	0	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr12:49416568C>A	uc001rta.3	-	51	16143	c.16143G>T	c.(16141-16143)GTG>GTT	p.V5381V		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5381					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ACTTGGAGTGCACAAACTGCT	0.587			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			A	49416568	A	A	49416568	2	1	153	1	0	0	0	0	0	0	0	1	9621	697	25	5		5	MLL2	12	49416568	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	40165293	49416568	84435327	118	10751											
KRT84	3890	broad.mit.edu	37	chr12	52771859	52771859	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggtggtggacacaaagcGgacgctggagctgcggccgc	19	10	0	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr12:52771859G>A	uc001sah.1	-	9	1810	c.1762C>T	c.(1762-1764)CGC>TGC	p.R588C		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	588	Tail.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GACACAAAGCGGACGCTGGAG	0.677													A	52771859	A	A	52771859	3	1	153	1	0	0	0	0	1	0	0	0	8498	1116	39	2	44	2	KRT84	12	52771859	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	3355291	52771859	81080036	119	10752											
KRT74	121391	broad.mit.edu	37	chr12	52960950	52960950	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagctgctactgctgatgaCagctgaggaggaggggccaa	16	8	0	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr12:52960950C>T	uc001sap.1	-	9	1441	c.1393G>A	c.(1393-1395)GTC>ATC	p.V465I		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	465	Tail.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		CTGCTGATGACAGCTGAGGAG	0.607													T	52960950	T	T	52960950	3	4	153	1	0	0	0	0	1	0	0	0	8487	478	17	3	200	3	KRT74	12	52960950	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	189091	52960950	80890945	120	10753											
ZBTB39	9880	broad.mit.edu	37	chr12	57397937	57397937	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gtgaggaagctgtttttactGaagtctccattgctttgaac	10	7	1	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr12:57397937G>T	uc001sml.1	-	2	851	c.765C>A	c.(763-765)TTC>TTA	p.F255L	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						TGTTTTTACTGAAGTCTCCAT	0.517													T	57397937	T	T	57397937	3	4	153	1	0	0	0	0	1	0	0	0	17537	1281	45	5	1377	5	ZBTB39	12	57397937	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	4436987	57397937	76453958	121	10754											
OS9	10956	broad.mit.edu	37	chr12	58112083	58112083	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatgaagatgaggatgaacGgcagttactgggagaatttg	16	3	0	5			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr12:58112083G>A	uc001spj.2	+	11	1348	c.1289G>A	c.(1288-1290)CGG>CAG	p.R430Q	OS9_uc010srx.1_Missense_Mutation_p.R224Q|OS9_uc001spk.2_Missense_Mutation_p.R430Q|OS9_uc001spl.2_Missense_Mutation_p.R430Q|OS9_uc001spm.2_Missense_Mutation_p.R430Q|OS9_uc001spn.2_Missense_Mutation_p.R431Q|OS9_uc010sry.1_Missense_Mutation_p.R398Q|OS9_uc010srz.1_Missense_Mutation_p.R371Q	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	430					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			gaggatgaACGGCAGTTACTG	0.413													A	58112083	A	A	58112083	3	1	153	1	0	0	0	0	1	0	0	0	11272	1116	39	2	1331	2	OS9	12	58112083	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	714146	58112083	75739812	122	10755											
PAH	5053	broad.mit.edu	37	chr12	103246597	103246597	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggaggacagtactcacggttCgggggtatacatgggcttgg	17	7	1	0	rs62508698		TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr12:103246597C>T	uc001tjq.1	-	8	1310	c.838G>A	c.(838-840)GAA>AAA	p.E280K		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	280			E -> K (in PKU; haplotypes 1,2,4,16,38; partial residual activity).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	ACTCACGGTTCGGGGGTATAC	0.547													T	103246597	T	T	103246597	3	4	153	1	0	0	0	0	1	0	0	0	11394	893	31	2	548	2	PAH	12	103246597	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	45134514	103246597	30605298	123	10756											
TCTN2	79867	broad.mit.edu	37	chr12	124156084	124156084	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccttttatccgaatgtccgGccctgcggtcagcgcgtccc	10	16	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr12:124156084G>A	uc001ufp.2	+	2	241	c.113G>A	c.(112-114)GGC>GAC	p.G38D	TCTN2_uc009zya.2_Missense_Mutation_p.G38D	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	38	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		CGAATGTCCGGCCCTGCGGTC	0.617													A	124156084	A	A	124156084	3	1	153	1	0	0	0	0	1	0	0	0	15720	1203	42	3	119	3	TCTN2	12	124156084	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	20909487	124156084	9695811	124	10757											
RNF17	56163	broad.mit.edu	37	chr13	25363875	25363875	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagatcatctgtatgttcaaCaatatgggaaagattgaatt	9	4	3	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr13:25363875C>A	uc001upr.2	+	9	941	c.900C>A	c.(898-900)AAC>AAA	p.N300K	RNF17_uc010tdd.1_Missense_Mutation_p.N159K|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.N300K|RNF17_uc001ups.2_Missense_Mutation_p.N239K|RNF17_uc001upq.1_Missense_Mutation_p.N300K	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	300					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GTATGTTCAACAATATGGGAA	0.308													A	25363875	A	A	25363875	3	1	153	1	0	0	0	0	1	0	0	0	13461	477	17	5	934	5	RNF17	13	25363875	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08		25363875	89806003	125	10758											
BRCA2	675	broad.mit.edu	37	chr13	32903619	32903619	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgaaactgtatttcctcatgAtactactgctgtaagtaaat	6	7	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr13:32903619A>T	uc001uub.1	+	8	898	c.671A>T	c.(670-672)GAT>GTT	p.D224V	BRCA2_uc001uua.1_Missense_Mutation_p.D101V	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	224					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TTTCCTCATGATACTACTGCT	0.259			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			T	32903619	T	T	32903619	3	4	153	1	0	0	0	0	1	0	0	0	1499	333	12	5	697	5	BRCA2	13	32903619	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08	7539744	32903619	82266259	126	10759											
TUBGCP3	10426	broad.mit.edu	37	chr13	113181294	113181294	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cagacttggtcacagctatcAtctttgtagtgggagtctga	11	8	4	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr13:113181294A>T	uc001vse.1	-	13	1704	c.1517T>A	c.(1516-1518)ATG>AAG	p.M506K	TUBGCP3_uc010tjq.1_Missense_Mutation_p.M496K|TUBGCP3_uc001vsf.2_Missense_Mutation_p.M506K	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	506					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CACAGCTATCATCTTTGTAGT	0.318													T	113181294	T	T	113181294	3	4	153	1	0	0	0	0	1	0	0	0	16764	217	8	5	1246	5	TUBGCP3	13	113181294	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08	80277675	113181294	1988584	127	10760											
TGM1	7051	broad.mit.edu	37	chr14	24729739	24729739	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccagcgtctgattgtgtgCggactgtgaactgaaacttg	12	10	1	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr14:24729739C>T	uc001wod.2	-	4	798	c.674G>A	c.(673-675)CGC>CAC	p.R225H	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	225			R -> P (in ARCI-TGM1).|R -> H (in ARCI-TGM1).		cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TGATTGTGTGCGGACTGTGAA	0.587													T	24729739	T	T	24729739	3	4	153	1	0	0	0	0	1	0	0	0	15826	768	27	1	1827	1	TGM1	14	24729739	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08		24729739	82619801	128	10761											
NYNRIN	57523	broad.mit.edu	37	chr14	24886187	24886187	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggcctccctgcctttgctGcacctggccttcagggcctc	11	18	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr14:24886187G>A	uc001wpf.3	+	9	5550	c.5232G>A	c.(5230-5232)CTG>CTA	p.L1744L		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1744	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						TGCCTTTGCTGCACCTGGCCT	0.622													A	24886187	A	A	24886187	2	1	153	1	0	0	0	0	0	0	0	1	10796	1306	46	3		3	NYNRIN	14	24886187	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	156448	24886187	82463353	129	10762											
FOXA1	3169	broad.mit.edu	37	chr14	38061688	38061688	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccgtacccatggccgtcaCgccggccgcagtcatgctgt	12	17	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr14:38061688C>T	uc001wuf.2	-	2	613	c.301G>A	c.(301-303)GTG>ATG	p.V101M	FOXA1_uc010tpz.1_Missense_Mutation_p.V68M	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	101					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		ATGGCCGTCACGCCGGCCGCA	0.741													T	38061688	T	T	38061688	3	4	153	1	0	0	0	0	1	0	0	0	5989	536	19	1	1121	1	FOXA1	14	38061688	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	13175501	38061688	69287852	130	10763											
PPM1A	5494	broad.mit.edu	37	chr14	60749967	60749967	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagaatgcaggtggctctgtAatgattcagcgtgtgaatgg	14	6	2	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr14:60749967A>G	uc010apn.2	+	3	948	c.546A>G	c.(544-546)GTA>GTG	p.V182V	PPM1A_uc001xew.3_Silent_p.V255V|PPM1A_uc001xex.3_Silent_p.V182V|PPM1A_uc001xey.3_Silent_p.V182V	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	182					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		GTGGCTCTGTAATGATTCAGC	0.443													G	60749967	G	G	60749967	2	3	153	1	0	0	0	0	0	0	0	1	12335	349	13	4		4	PPM1A	14	60749967	Silent	SNP	A	TCGA-19-1790-01B-01D-1353-08	22688279	60749967	46599573	131	10764											
AHNAK2	113146	broad.mit.edu	37	chr14	105409035	105409035	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccacgacgggggtcatcacAtccgccttggggcctttcag	12	14	3	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr14:105409035A>G	uc010axc.1	-	7	12873	c.12753T>C	c.(12751-12753)GAT>GAC	p.D4251D	AHNAK2_uc001ypx.2_Silent_p.D4151D	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4251						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGTCATCACATCCGCCTTGG	0.642													G	105409035	G	G	105409035	2	3	153	1	0	0	0	0	0	0	0	1	415	214	8	4		4	AHNAK2	14	105409035	Silent	SNP	A	TCGA-19-1790-01B-01D-1353-08	44659068	105409035	1940505	132	10765											
GABRB3	2562	broad.mit.edu	37	chr15	26866466	26866466	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagaggcacacagacctgagCccatacagcactgtcccatc	8	15	0	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr15:26866466C>G	uc001zaz.2	-	4	598	c.456G>C	c.(454-456)GGG>GGC	p.G152G	GABRB3_uc010uae.1_Silent_p.G67G|GABRB3_uc001zba.2_Silent_p.G152G|GABRB3_uc001zbb.2_Silent_p.G208G|GABRB3_uc001zbc.2_RNA	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	152	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAGACCTGAGCCCATACAGCA	0.448													G	26866466	G	G	26866466	2	3	153	1	0	0	0	0	0	0	0	1	6168	726	26	5		5	GABRB3	15	26866466	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08		26866466	75664926	133	10766											
TCF12	6938	broad.mit.edu	37	chr15	57543615	57543615	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agctatgaaaactcactccaCtccctggtaagagcctctta	6	13	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr15:57543615C>G	uc002aec.2	+	14	1466	c.1182C>G	c.(1180-1182)CAC>CAG	p.H394Q	TCF12_uc010ugm.1_Missense_Mutation_p.H446Q|TCF12_uc010ugn.1_Missense_Mutation_p.H390Q|TCF12_uc002aea.2_Missense_Mutation_p.H394Q|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Missense_Mutation_p.H394Q|TCF12_uc002aed.2_Missense_Mutation_p.H394Q|TCF12_uc002aee.2_Missense_Mutation_p.H224Q|TCF12_uc010bft.2_Missense_Mutation_p.H224Q|TCF12_uc010ugo.1_Missense_Mutation_p.H158Q|TCF12_uc010ugp.1_Missense_Mutation_p.H28Q|TCF12_uc010ugq.1_Missense_Mutation_p.H28Q|TCF12_uc010ugr.1_5'Flank	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	394					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ACTCACTCCACTCCCTGGTAA	0.448			T	TEC	extraskeletal myxoid chondrosarcoma								G	57543615	G	G	57543615	3	3	153	1	0	0	0	0	1	0	0	0	15684	564	20	5	1305	5	TCF12	15	57543615	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	30677149	57543615	44987777	134	10767											
AQP9	366	broad.mit.edu	37	chr15	58476317	58476317	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaaaccagagaaatatgaaCtcagtgtcatcatgtagtgg	9	7	3	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr15:58476317C>T	uc002aez.2	+	6	1228	c.871C>T	c.(871-873)CTC>TTC	p.L291F	ALDH1A2_uc010ugw.1_Intron|AQP9_uc010ugx.1_Missense_Mutation_p.L226F	NM_020980	NP_066190	O43315	AQP9_HUMAN	aquaporin 9	291	Cytoplasmic (Potential).				cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			ovary(1)	1				GBM - Glioblastoma multiforme(80;0.16)		GAAATATGAACTCAGTGTCAT	0.438													T	58476317	T	T	58476317	3	4	153	1	0	0	0	0	1	0	0	0	833	565	20	3	893	3	AQP9	15	58476317	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	932702	58476317	44055075	135	10768											
BNC1	646	broad.mit.edu	37	chr15	83933192	83933192	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tttggggtcctgactttggtCatgaccctgctccaacatat	9	11	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr15:83933192C>G	uc002bjt.1	-	4	899	c.811G>C	c.(811-813)GAC>CAC	p.D271H	BNC1_uc010uos.1_Missense_Mutation_p.D259H	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	271					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TGACTTTGGTCATGACCCTGC	0.488													G	83933192	G	G	83933192	3	3	153	1	0	0	0	0	1	0	0	0	1474	826	29	5	2181	5	BNC1	15	83933192	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	25456875	83933192	18598200	136	10769											
CHSY1	22856	broad.mit.edu	37	chr15	101775678	101775678	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	acttcttctggggcgggtagGagtcgtccacaccccgtagt	13	12	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr15:101775678G>T	uc002bwt.1	-	3	908	c.425C>A	c.(424-426)TCC>TAC	p.S142Y		NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	142	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GGGCGGGTAGGAGTCGTCCAC	0.483													T	101775678	T	T	101775678	3	4	153	1	0	0	0	0	1	0	0	0	3412	1174	41	5	1991	5	CHSY1	15	101775678	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	17842486	101775678	755714	137	10770											
PTX4	390667	broad.mit.edu	37	chr16	1537375	1537375	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gggtcttttggggcagtcccActgagtacccgatggctgcc	14	12	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr16:1537375A>T	uc010uvf.1	-	2	723	c.723T>A	c.(721-723)AGT>AGA	p.S241R		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	246						extracellular region	metal ion binding				0						GGGCAGTCCCACTGAGTACCC	0.677													T	1537375	T	T	1537375	3	4	153	1	0	0	0	0	1	0	0	0	12823	156	6	5	705	5	PTX4	16	1537375	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08		1537375	88817378	138	10771											
PKD1	5310	broad.mit.edu	37	chr16	2160687	2160687	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccacaggtagctggcggggCgcccacggcccacagcagag	15	16	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr16:2160687C>T	uc002cos.1	-	15	4690	c.4481G>A	c.(4480-4482)CGC>CAC	p.R1494H	PKD1_uc002cot.1_Missense_Mutation_p.R1494H	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1494	Extracellular (Potential).|PKD 10.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GCTGGCGGGGCGCCCACGGCC	0.652													T	2160687	T	T	2160687	3	4	153	1	0	0	0	0	1	0	0	0	11963	768	27	1	8558	1	PKD1	16	2160687	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	623312	2160687	88194066	139	10772											
ADCY7	113	broad.mit.edu	37	chr16	50349362	50349362	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aaaggcaaaggcgagctgagGacttactttgtctgtacgga	13	7	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr16:50349362G>T	uc002egd.1	+	25	3457	c.3189G>T	c.(3187-3189)AGG>AGT	p.R1063S		NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	1063	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	GCGAGCTGAGGACTTACTTTG	0.572													T	50349362	T	T	50349362	3	4	153	1	0	0	0	0	1	0	0	0	299	1165	41	5	3287	5	ADCY7	16	50349362	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	48188675	50349362	40005391	140	10773											
CES7	221223	broad.mit.edu	37	chr16	55907825	55907825	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaaatcgcagggatcccagCgggggagcagcaaaggggac	17	9	0	0	rs113880150	byFrequency	TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr16:55907825C>T	uc002eip.2	-	2	347	c.198G>A	c.(196-198)CCG>CCA	p.P66P	CES7_uc002eio.2_Silent_p.P66P|CES7_uc002eiq.2_5'UTR|CES7_uc002eir.2_5'UTR	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	66						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		GGGATCCCAGCGGGGGAGCAG	0.597													T	55907825	T	T	55907825	2	4	153	1	0	0	0	0	0	0	0	1	3272	755	27	1		1	CES7	16	55907825	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	5558463	55907825	34446928	141	10774											
E2F4	1874	broad.mit.edu	37	chr16	67226947	67226947	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgcaatacccgggagattgCtgacaaactgattgagctca	10	10	1	4			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr16:67226947C>G	uc002erz.2	+	3	344	c.281C>G	c.(280-282)GCT>GGT	p.A94G	EXOC3L_uc002erv.1_5'Flank|EXOC3L_uc002erw.1_5'Flank|EXOC3L_uc002ery.1_5'Flank|EXOC3L_uc010vje.1_5'Flank|EXOC3L_uc002erx.1_5'Flank	NM_001950	NP_001941	Q16254	E2F4_HUMAN	E2F transcription factor 4	94	Dimerization (Potential).				G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		CGGGAGATTGCTGACAAACTG	0.612													G	67226947	G	G	67226947	3	3	153	1	0	0	0	0	1	0	0	0	4869	797	28	5	291	5	E2F4	16	67226947	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	11319122	67226947	23127806	142	10775											
C17orf100	388327	broad.mit.edu	37	chr17	6555309	6555309	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acacagagacgtccacggtcCgcgtggagacctcgtcccac	11	16	0	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr17:6555309C>A	uc010clp.1	+	1	251	c.76C>A	c.(76-78)CGC>AGC	p.R26S	MED31_uc002gdg.3_5'Flank|MED31_uc002gdh.3_5'Flank	NM_001105520	NP_001098990	D3DTM5	D3DTM5_HUMAN	hypothetical protein LOC388327	26											0						GTCCACGGTCCGCGTGGAGAC	0.736													A	6555309	A	A	6555309	3	1	153	1	0	0	0	0	1	0	0	0	1847	652	23	5	78	5	C17orf100	17	6555309	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08		6555309	74639901	143	10776											
SLFN13	146857	broad.mit.edu	37	chr17	33771684	33771684	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attcctcagttgtcaaggggCggatgtacttctccctcacc	9	13	4	0	rs148604980		TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr17:33771684C>T	uc002hjk.1	-	1	1346	c.1016G>A	c.(1015-1017)CGC>CAC	p.R339H	SLFN13_uc010wch.1_Missense_Mutation_p.R339H|SLFN13_uc002hjl.2_Missense_Mutation_p.R339H|SLFN13_uc010ctt.2_Missense_Mutation_p.R21H|SLFN13_uc002hjm.2_Missense_Mutation_p.R8H	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	339						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TGTCAAGGGGCGGATGTACTT	0.488													T	33771684	T	T	33771684	3	4	153	1	0	0	0	0	1	0	0	0	14736	768	27	1	1693	1	SLFN13	17	33771684	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	27216375	33771684	47423526	144	10777											
IKZF3	22806	broad.mit.edu	37	chr17	37985642	37985642	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctgcacactacggctcacctCctatgtcttcatcttcattg	5	15	5	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr17:37985642C>G	uc002hsu.2	-	3	223	c.161G>C	c.(160-162)GGA>GCA	p.G54A	IKZF3_uc002htd.2_Intron|IKZF3_uc010cwd.2_Missense_Mutation_p.G54A|IKZF3_uc002hsv.2_Intron|IKZF3_uc010cwe.2_Missense_Mutation_p.G54A|IKZF3_uc010cwf.2_Missense_Mutation_p.G54A|IKZF3_uc010cwg.2_Missense_Mutation_p.G54A|IKZF3_uc002hsw.2_Missense_Mutation_p.G54A|IKZF3_uc002hsx.2_Missense_Mutation_p.G54A|IKZF3_uc002hsy.2_Missense_Mutation_p.G54A|IKZF3_uc002hsz.2_Missense_Mutation_p.G54A|IKZF3_uc002hta.2_Missense_Mutation_p.G54A|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Missense_Mutation_p.G54A|IKZF3_uc002htc.2_5'UTR	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	54					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CGGCTCACCTCCTATGTCTTC	0.428													G	37985642	G	G	37985642	3	3	153	1	0	0	0	0	1	0	0	0	7616	855	30	5	1392	5	IKZF3	17	37985642	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	4213958	37985642	43209568	145	10778											
NAGS	162417	broad.mit.edu	37	chr17	42085912	42085912	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gactcctatgagttggtcaaCcacgccaagggactgccaga	11	12	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr17:42085912C>A	uc002ies.2	+	7	1548	c.1548C>A	c.(1546-1548)AAC>AAA	p.N516K	NAGS_uc010czn.2_Missense_Mutation_p.N524K|NAGS_uc002iet.2_Missense_Mutation_p.N140K	NM_153006	NP_694551	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	516	N-acetyltransferase.				arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity				0		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	AGTTGGTCAACCACGCCAAGG	0.557													A	42085912	A	A	42085912	3	1	153	1	0	0	0	0	1	0	0	0	10145	506	18	5	1574	5	NAGS	17	42085912	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	4100270	42085912	39109298	146	10779											
SEPT4	5414	broad.mit.edu	37	chr17	56603127	56603127	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tattgacaagtgtggatttgCccaggccagactctcctgag	11	10	1	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr17:56603127C>T	uc002iwm.1	-	4	595	c.467G>A	c.(466-468)GGC>GAC	p.G156D	SEPT4_uc002iwk.1_Missense_Mutation_p.G9D|SEPT4_uc010wnw.1_Missense_Mutation_p.G9D|SEPT4_uc002iwl.1_Missense_Mutation_p.G9D|SEPT4_uc002iwn.1_Missense_Mutation_p.G57D|SEPT4_uc002iwo.1_Missense_Mutation_p.G137D|SEPT4_uc002iwp.1_Missense_Mutation_p.G137D|SEPT4_uc010wnx.1_Missense_Mutation_p.G171D|SEPT4_uc010wny.1_Missense_Mutation_p.G148D|SEPT4_uc010dcy.1_Missense_Mutation_p.G38D	NM_004574	NP_004565	O43236	SEPT4_HUMAN	septin 4 isoform 1	156	GTP (By similarity).			G -> D (in Ref. 7; BAG37789).|GKS->ENP: Loss of TGF-beta-induced apoptosis. No translocation to the nucleus following TGF-beta treatment. Loss of XIAP-binding.	apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGTGGATTTGCCCAGGCCAGA	0.502													T	56603127	T	T	56603127	3	4	153	1	0	0	0	0	1	0	0	0	14066	739	26	3	1090	3	SEPT4	17	56603127	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	14517215	56603127	24592083	147	10780											
CD7	924	broad.mit.edu	37	chr17	80274632	80274632	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtgtccgacagctgcaggCggtgcatggtgatagtcagg	16	9	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr17:80274632C>T	uc002kel.1	-	2	417	c.308G>A	c.(307-309)CGC>CAC	p.R103H	CD7_uc010din.2_Missense_Mutation_p.R103H|CD7_uc002kem.2_Silent_p.P84P|CD7_uc010wvk.1_Missense_Mutation_p.R103H	NM_006137	NP_006128	P09564	CD7_HUMAN	CD7 antigen precursor	103	Ig-like.|Extracellular (Probable).				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			CAGCTGCAGGCGGTGCATGGT	0.612													T	80274632	T	T	80274632	3	4	153	1	0	0	0	0	1	0	0	0	3032	768	27	1	426	1	CD7	17	80274632	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	23671505	80274632	920578	148	10781											
B3GNTL1	146712	broad.mit.edu	37	chr17	80915279	80915279	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gctgcggtacagccggcgccCctgcttgccagcgttccaga	13	16	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr17:80915279C>G	uc002kgg.1	-	9	831	c.817G>C	c.(817-819)GGG>CGG	p.G273R	B3GNTL1_uc002kgf.1_Missense_Mutation_p.G162R|B3GNTL1_uc002kge.1_RNA	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	273							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			AGCCGGCGCCCCTGCTTGCCA	0.692													G	80915279	G	G	80915279	3	3	153	1	0	0	0	0	1	0	0	0	1265	623	22	5	284	5	B3GNTL1	17	80915279	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	640647	80915279	279931	149	10782											
SMCHD1	23347	broad.mit.edu	37	chr18	2700592	2700592	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atacttgagaaagcagctagAgggaaaaggcctatttttga	11	5	0	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr18:2700592A>T	uc002klm.3	+	11	1587	c.1398A>T	c.(1396-1398)AGA>AGT	p.R466S	SMCHD1_uc002klk.3_5'Flank	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	466					chromosome organization		ATP binding				0						AAGCAGCTAGAGGGAAAAGGC	0.303													T	2700592	T	T	2700592	3	4	153	1	0	0	0	0	1	0	0	0	14788	301	11	5	1440	5	SMCHD1	18	2700592	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08		2700592	75376656	150	10783											
C18orf8	29919	broad.mit.edu	37	chr18	21089223	21089223	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aaattgtcttcataacagatCaaggaatcgaattttaccag	6	7	3	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr18:21089223C>G	uc010xax.1	+	5	509	c.388C>G	c.(388-390)CAA>GAA	p.Q130E	C18orf8_uc010xau.1_Translation_Start_Site|C18orf8_uc010xav.1_Intron|C18orf8_uc010xaw.1_Intron|C18orf8_uc002kul.2_RNA	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	130										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CATAACAGATCAAGGAATCGA	0.294													G	21089223	G	G	21089223	3	3	153	1	0	0	0	0	1	0	0	0	1907	827	29	5	406	5	C18orf8	18	21089223	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	18388631	21089223	56988025	151	10784											
DSG4	147409	broad.mit.edu	37	chr18	28968938	28968938	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gataacgctccagtcttttcGcaaagtgtatacacagccag	8	11	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr18:28968938G>A	uc002kwq.2	+	5	609	c.474G>A	c.(472-474)TCG>TCA	p.S158S	DSG4_uc002kwr.2_Silent_p.S158S	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	158	Cadherin 2.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAGTCTTTTCGCAAAGTGTAT	0.413													A	28968938	A	A	28968938	2	1	153	1	0	0	0	0	0	0	0	1	4779	1074	38	1		1	DSG4	18	28968938	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	7879715	28968938	49108310	152	10785											
NOL4	8715	broad.mit.edu	37	chr18	31432915	31432915	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacggcattgatttcagttGgactcagctggggtctggag	14	8	4	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr18:31432915G>A	uc010dmi.2	-	11	2037	c.1808C>T	c.(1807-1809)CCA>CTA	p.P603L	NOL4_uc010xbs.1_Missense_Mutation_p.P318L|NOL4_uc002kxr.3_Missense_Mutation_p.P375L|NOL4_uc010xbt.1_Missense_Mutation_p.P529L|NOL4_uc010dmh.2_Missense_Mutation_p.P465L|NOL4_uc010xbu.1_Missense_Mutation_p.P539L|NOL4_uc002kxt.3_Missense_Mutation_p.P501L	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	603						nucleolus	RNA binding			ovary(3)	3						GATTTCAGTTGGACTCAGCTG	0.448													A	31432915	A	A	31432915	3	1	153	1	0	0	0	0	1	0	0	0	10524	1348	47	3	112	3	NOL4	18	31432915	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	2463977	31432915	46644333	153	10786											
MYO5B	4645	broad.mit.edu	37	chr18	47405384	47405384	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtgaatattccttcacaagGttctggtaccgggatcgctc	10	10	2	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr18:47405384G>T	uc002leb.2	-	24	3495	c.3207C>A	c.(3205-3207)AAC>AAA	p.N1069K	MYO5B_uc002lea.2_Missense_Mutation_p.N210K	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1069	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CCTTCACAAGGTTCTGGTACC	0.488													T	47405384	T	T	47405384	3	4	153	1	0	0	0	0	1	0	0	0	10079	1252	44	5	2407	5	MYO5B	18	47405384	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	15972469	47405384	30671864	154	10787											
CCBE1	147372	broad.mit.edu	37	chr18	57105364	57105364	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagaccctctgggcccaggCgctcctctctccccctaaaa	9	18	2	1	rs144169027		TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr18:57105364C>T	uc002lib.2	-	10	1036	c.966G>A	c.(964-966)GCG>GCA	p.A322A	CCBE1_uc010dpq.2_Silent_p.A51A|CCBE1_uc002lia.2_Silent_p.A175A	NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	322	Collagen-like 2.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				TGGGCCCAGGCGCTCCTCTCT	0.507													T	57105364	T	T	57105364	2	4	153	1	0	0	0	0	0	0	0	1	2731	755	27	1		1	CCBE1	18	57105364	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	9699980	57105364	20971884	155	10788											
TNFRSF11A	8792	broad.mit.edu	37	chr18	60033975	60033975	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggatcaatgaggcttgtggCcgcctaagtggagataaggt	15	6	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr18:60033975C>T	uc002lin.2	+	8	803	c.765C>T	c.(763-765)GGC>GGT	p.G255G	TNFRSF11A_uc010dpv.2_Intron	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	255	Cytoplasmic (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				AGGCTTGTGGCCGCCTAAGTG	0.403									Paget_Disease_of_Bone				T	60033975	T	T	60033975	2	4	153	1	0	0	0	0	0	0	0	1	16281	726	26	3		3	TNFRSF11A	18	60033975	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	2928611	60033975	18043273	156	10789											
RTTN	25914	broad.mit.edu	37	chr18	67718720	67718720	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	atggcaccagctttcctcagGagcatggccagaagattaaa	10	10	1	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr18:67718720G>T	uc002lkp.2	-	39	5318	c.5250C>A	c.(5248-5250)CTC>CTA	p.L1750L	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.L838L|RTTN_uc010dqp.2_Silent_p.L2L	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1750							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				CTTTCCTCAGGAGCATGGCCA	0.408													T	67718720	T	T	67718720	2	4	153	1	0	0	0	0	0	0	0	1	13737	1161	41	5		5	RTTN	18	67718720	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	7684745	67718720	10358528	157	10790											
SALL3	27164	broad.mit.edu	37	chr18	76757007	76757007	+	Frame_Shift_Del	DEL	C	-	-													ctgaagttctctgaaatgttCcagaaggacctggcagctcg							TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr18:76757007delC	uc002lmt.2	+	3	3588	c.3588delC	c.(3586-3588)TTCfs	p.F1196fs	SALL3_uc010dra.2_Frame_Shift_Del_p.F731fs	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CTGAAATGTTCCAGAAGGACC	0.577													-	76757007	-	-	76757007	7	5	153	1	0	1	0	1	0	0	0	0	13812	854	30	0	3598	0	SALL3	18	76757007	Frame_Shift_Del	DEL	C	TCGA-19-1790-01B-01D-1353-08	9038287	76757007	1320241	158	10791											
TCF3	6929	broad.mit.edu	37	chr19	1619469	1619469	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccaggtggtcttctatcttaCtctgctgcagggtgggggga	15	9	4	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:1619469C>G	uc002ltr.2	-	15	1239	c.1172G>C	c.(1171-1173)AGT>ACT	p.S391T	TCF3_uc002lto.2_Missense_Mutation_p.S152T|TCF3_uc002ltt.3_Missense_Mutation_p.S391T|TCF3_uc002ltq.2_Missense_Mutation_p.S340T|TCF3_uc002lts.1_Missense_Mutation_p.S307T|TCF3_uc010dso.1_Intron	NM_003200	NP_003191	P15923	TFE2_HUMAN	transcription factor 3 isoform E12	391	Leucine-zipper.				B cell lineage commitment|B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			lung(2)|breast(2)|ovary(1)|large_intestine(1)|skin(1)	7		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTATCTTACTCTGCTGCAG	0.682			T	PBX1|HLF|TFPT	pre B-ALL								G	1619469	G	G	1619469	3	3	153	1	0	0	0	0	1	0	0	0	15691	565	20	5	1043	5	TCF3	19	1619469	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08		1619469	57509514	159	10792											
RFX2	5990	broad.mit.edu	37	chr19	6007158	6007158	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgtccttgggcaggacggCgccctcggggtcttcgtcac	14	14	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:6007158C>T	uc002meb.2	-	12	1536	c.1267G>A	c.(1267-1269)GCC>ACC	p.A423T	RFX2_uc002mec.2_Missense_Mutation_p.A398T|RFX2_uc002med.1_3'UTR	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6						GGCAGGACGGCGCCCTCGGGG	0.662													T	6007158	T	T	6007158	3	4	153	1	0	0	0	0	1	0	0	0	13263	768	27	1	932	1	RFX2	19	6007158	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	4387689	6007158	53121825	160	10793											
MAN2B1	4125	broad.mit.edu	37	chr19	12757445	12757445	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccagcagacctaaccatccaCctccttccattgaactgagg	6	16	0	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:12757445C>A	uc002mub.2	-	24	3101	c.3025G>T	c.(3025-3027)GTG>TTG	p.V1009L	MAN2B1_uc010dyv.1_Missense_Mutation_p.V1008L	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	1009					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						TAACCATCCACCTCCTTCCAT	0.602													A	12757445	A	A	12757445	3	1	153	1	0	0	0	0	1	0	0	0	9216	507	18	5	14	5	MAN2B1	19	12757445	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	6750287	12757445	46371538	161	10794											
DCAF15	90379	broad.mit.edu	37	chr19	14065391	14065391	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacgtcctctcctacaccaGcagcagtggggatgacgact	10	14	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:14065391G>A	uc002mxt.2	+	3	290	c.284G>A	c.(283-285)AGC>AAC	p.S95N	PODNL1_uc010xnj.1_5'Flank|PODNL1_uc002mxs.2_5'Flank	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	95										central_nervous_system(1)	1						TCCTACACCAGCAGCAGTGGG	0.582													A	14065391	A	A	14065391	3	1	153	1	0	0	0	0	1	0	0	0	4267	971	34	3	294	3	DCAF15	19	14065391	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	1307946	14065391	45063592	162	10795											
MAP1S	55201	broad.mit.edu	37	chr19	17844118	17844118	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtggatgaggagttcttcCagcgcgtgcgcgcgctctgc	16	11	2	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:17844118C>T	uc002nhe.1	+	6	2914	c.2905C>T	c.(2905-2907)CAG>TAG	p.Q969*	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_Nonsense_Mutation_p.Q217*|MAP1S_uc010xpv.1_Nonsense_Mutation_p.Q943*	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	969	Necessary for association with actin (By similarity).|Necessary for interaction with RASSF1 isoform A and isoform C.|Necessary for the mitochondrial aggregation and genome destruction.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						GGAGTTCTTCCAGCGCGTGCG	0.687													T	17844118	T	T	17844118	4	4	153	1	0	0	0	0	0	1	0	0	9234	595	21	3	2927	3	MAP1S	19	17844118	Nonsense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	3778727	17844118	41284865	163	10796											
ATP13A1	57130	broad.mit.edu	37	chr19	19756301	19756301	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggtcggccaggagcgccaggCagaagtccaggagcaggacc	17	12	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:19756301C>G	uc002nnh.3	-	26	3573	c.3545G>C	c.(3544-3546)TGC>TCC	p.C1182S	GMIP_uc002nnd.2_5'Flank|GMIP_uc010xrb.1_5'Flank|GMIP_uc010xrc.1_5'Flank|ATP13A1_uc002nne.2_Missense_Mutation_p.C322S|ATP13A1_uc002nnf.3_Missense_Mutation_p.C550S|ATP13A1_uc002nng.2_Missense_Mutation_p.C1064S	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	ATPase type 13A1	1182	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(3)|large_intestine(2)|central_nervous_system(1)	6						GAGCGCCAGGCAGAAGTCCAG	0.647													G	19756301	G	G	19756301	3	3	153	1	0	0	0	0	1	0	0	0	1123	710	25	5	73	5	ATP13A1	19	19756301	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	1912183	19756301	39372682	164	10797											
GRAMD1A	57655	broad.mit.edu	37	chr19	35512755	35512755	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gacccctgtgcccgggccggCattcacacctcgggtacgtt	12	16	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:35512755C>A	uc010xse.1	+	15	1877	c.1740C>A	c.(1738-1740)GGC>GGA	p.G580G	GRAMD1A_uc002nxk.2_Silent_p.G573G|GRAMD1A_uc002nxl.2_Silent_p.G346G|GRAMD1A_uc010xsf.1_Silent_p.G585G|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Silent_p.G195G	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	580						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CCCGGGCCGGCATTCACACCT	0.711													A	35512755	A	A	35512755	2	1	153	1	0	0	0	0	0	0	0	1	6747	697	25	5		5	GRAMD1A	19	35512755	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	15756454	35512755	23616228	165	10798											
ZNF565	147929	broad.mit.edu	37	chr19	36673611	36673611	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcccacattccttacattcGtagggtttgtcacctgtatg	7	11	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:36673611G>A	uc002odn.2	-	5	1365	c.1257C>T	c.(1255-1257)TAC>TAT	p.Y419Y	ZNF565_uc010ees.2_Silent_p.Y354Y|ZNF565_uc002odo.2_Silent_p.Y419Y	NM_152477	NP_689690	Q8N9K5	ZN565_HUMAN	zinc finger protein 565	419	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			CCTTACATTCGTAGGGTTTGT	0.448													A	36673611	A	A	36673611	2	1	153	1	0	0	0	0	0	0	0	1	17993	1140	40	1		1	ZNF565	19	36673611	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	1160856	36673611	22455372	166	10799											
SIRT2	22933	broad.mit.edu	37	chr19	39371782	39371782	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgcgctgggaggctctcaccAaaaaagacgatatctgaggt	12	10	2	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:39371782A>C	uc002ojt.1	-	11	905	c.705T>G	c.(703-705)TTT>TTG	p.F235L	RINL_uc002ojq.2_5'Flank|RINL_uc010xuo.1_5'Flank|SIRT2_uc010egh.1_Missense_Mutation_p.F198L|SIRT2_uc010egi.1_Missense_Mutation_p.F198L|SIRT2_uc002ojs.1_Missense_Mutation_p.F215L|SIRT2_uc002oju.1_Missense_Mutation_p.F198L|SIRT2_uc010egj.1_Missense_Mutation_p.F198L|SIRT2_uc002ojv.1_Missense_Mutation_p.F233L	NM_012237	NP_036369	Q8IXJ6	SIRT2_HUMAN	sirtuin 2 isoform 1	235	Deacetylase sirtuin-type.				cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			GGCTCTCACCAAAAAAGACGA	0.617													C	39371782	C	C	39371782	3	2	153	1	0	0	0	0	1	0	0	0	14338	127	5	5	488	5	SIRT2	19	39371782	Missense_Mutation	SNP	A	TCGA-19-1790-01B-01D-1353-08	2698171	39371782	19757201	167	10800											
PSG5	5673	broad.mit.edu	37	chr19	43689016	43689016	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtaaggtgtaggatcctgcGtcttcccgggtgacattctg	13	9	2	1	rs143404539	byFrequency	TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:43689016G>A	uc002ovu.2	-	2	479	c.348C>T	c.(346-348)GAC>GAT	p.D116D	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Silent_p.D44D|PSG5_uc002ovx.2_Silent_p.D116D|PSG5_uc002ovv.2_Silent_p.D116D|PSG5_uc002ovw.2_Silent_p.D116D	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	116	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				AGGATCCTGCGTCTTCCCGGG	0.438													A	43689016	A	A	43689016	2	1	153	1	0	0	0	0	0	0	0	1	12658	1136	40	1		1	PSG5	19	43689016	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	4317234	43689016	15439967	168	10801											
PRKD2	25865	broad.mit.edu	37	chr19	47197301	47197301	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	taggtggcattggcagtgacGatctcaaagcagtgtgggtt	15	6	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:47197301G>A	uc002pfh.2	-	11	1749	c.1407C>T	c.(1405-1407)ATC>ATT	p.I469I	PRKD2_uc010ekt.2_5'Flank|PRKD2_uc002pfe.2_5'UTR|PRKD2_uc002pff.2_5'UTR|PRKD2_uc002pfg.2_Silent_p.I312I|PRKD2_uc002pfi.2_Silent_p.I469I|PRKD2_uc002pfj.2_Silent_p.I469I|PRKD2_uc010xye.1_Silent_p.I469I|PRKD2_uc002pfk.2_Silent_p.I312I	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	469	PH.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		TGGCAGTGACGATCTCAAAGC	0.647													A	47197301	A	A	47197301	2	1	153	1	0	0	0	0	0	0	0	1	12519	1048	37	2		2	PRKD2	19	47197301	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	3508285	47197301	11931682	169	10802											
DHX34	9704	broad.mit.edu	37	chr19	47879753	47879753	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgcaccccacctgcgtcttCgctggcagccccgaggtgct	11	18	1	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:47879753C>T	uc010xyn.1	+	12	2876	c.2535C>T	c.(2533-2535)TTC>TTT	p.F845F	DHX34_uc010xyo.1_5'Flank	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	845						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CCTGCGTCTTCGCTGGCAGCC	0.652													T	47879753	T	T	47879753	2	4	153	1	0	0	0	0	0	0	0	1	4507	883	31	2		2	DHX34	19	47879753	Silent	SNP	C	TCGA-19-1790-01B-01D-1353-08	682452	47879753	11249230	170	10803											
ZNF649	65251	broad.mit.edu	37	chr19	52394397	52394397	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgatgtatgttgagattgCccttctgaatgaagcctttt	10	6	1	4			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:52394397C>T	uc002pxy.2	-	5	1260	c.992G>A	c.(991-993)GGC>GAC	p.G331D	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	331	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		GTTGAGATTGCCCTTCTGAAT	0.453													T	52394397	T	T	52394397	3	4	153	1	0	0	0	0	1	0	0	0	18061	739	26	3	529	3	ZNF649	19	52394397	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	4514644	52394397	6734586	171	10804											
ZNF347	84671	broad.mit.edu	37	chr19	53645153	53645153	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acgtttttcgccagtatggaTcacctgatgggtagttaggt	12	7	1	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:53645153T>A	uc002qbb.1	-	5	997	c.928A>T	c.(928-930)ATC>TTC	p.I310F	ZNF347_uc010eql.1_Missense_Mutation_p.I311F|ZNF347_uc002qbc.1_Missense_Mutation_p.I311F	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	310	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		CCAGTATGGATCACCTGATGG	0.388													A	53645153	A	A	53645153	3	1	153	1	0	0	0	0	1	0	0	0	17858	1435	50	5	1595	5	ZNF347	19	53645153	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	1250756	53645153	5483830	172	10805											
NLRP7	199713	broad.mit.edu	37	chr19	55447703	55447703	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atcatcgtgcgttcccactcGatgtgccctgccagggtcag	11	14	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:55447703G>A	uc002qih.3	-	6	2302	c.2226C>T	c.(2224-2226)ATC>ATT	p.I742I	NLRP7_uc002qig.3_Silent_p.I714I|NLRP7_uc002qii.3_Silent_p.I742I|NLRP7_uc010esk.2_Silent_p.I742I|NLRP7_uc010esl.2_Silent_p.I770I	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	742							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GTTCCCACTCGATGTGCCCTG	0.552													A	55447703	A	A	55447703	2	1	153	1	0	0	0	0	0	0	0	1	10482	1048	37	2		2	NLRP7	19	55447703	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	1802550	55447703	3681280	173	10806											
ZNF329	79673	broad.mit.edu	37	chr19	58640193	58640193	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagtataaggcttctctccGgtgtgagttcggtgatgcaa	12	8	1	2	rs116840582	byFrequency	TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr19:58640193G>A	uc002qrn.2	-	4	915	c.678C>T	c.(676-678)ACC>ACT	p.T226T	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		GCTTCTCTCCGGTGTGAGTTC	0.433													A	58640193	A	A	58640193	2	1	153	1	0	0	0	0	0	0	0	1	17844	1103	39	2		2	ZNF329	19	58640193	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	3192490	58640193	488790	174	10807											
RBCK1	10616	broad.mit.edu	37	chr20	409649	409649	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagtgccagatcgtggtaCagaagaaggacggctgcgac	14	11	0	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr20:409649C>T	uc002wdp.3	+	11	2056	c.1363C>T	c.(1363-1365)CAG>TAG	p.Q455*	RBCK1_uc002wdq.3_Nonsense_Mutation_p.Q413*|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Nonsense_Mutation_p.Q285*	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	455	IBR-type 2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				GATCGTGGTACAGAAGAAGGA	0.682													T	409649	T	T	409649	4	4	153	1	0	0	0	0	0	1	0	0	13107	479	17	3	1424	3	RBCK1	20	409649	Nonsense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08		409649	62615871	175	10808											
RBPJL	11317	broad.mit.edu	37	chr20	43936878	43936878	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccgacaggcggagcctcccgGgcacttggaccaggtaacgg	15	14	0	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr20:43936878G>T	uc002xns.2	+	2	190	c.118G>T	c.(118-120)GGC>TGC	p.G40C	MATN4_uc002xnn.2_5'UTR|MATN4_uc002xno.2_5'UTR|MATN4_uc002xnp.2_5'UTR|MATN4_uc010zwr.1_5'Flank|MATN4_uc002xnr.1_5'UTR|RBPJL_uc002xnt.2_Missense_Mutation_p.G40C	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	40					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GAGCCTCCCGGGCACTTGGAC	0.642													T	43936878	T	T	43936878	3	4	153	1	0	0	0	0	1	0	0	0	13162	1232	43	5	124	5	RBPJL	20	43936878	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	43527229	43936878	19088642	176	10809											
GGTLC2	91227	broad.mit.edu	37	chr22	22989259	22989259	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccgctccccggtcagcgagaTcctgttcaatgatgaaatgg	11	12	2	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr22:22989259T>A	uc010gtt.2	+	2	246	c.212T>A	c.(211-213)ATC>AAC	p.I71N	LOC96610_uc011aim.1_Intron|POM121L1P_uc011ait.1_5'Flank|GGTLC2_uc010gts.2_Missense_Mutation_p.I71N	NM_199127	NP_954578	Q14390	GGTL2_HUMAN	gamma-glutamyltransferase-like 4 isoform 1	71					glutathione biosynthetic process		gamma-glutamyltransferase activity			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		GTCAGCGAGATCCTGTTCAAT	0.592													A	22989259	A	A	22989259	3	1	153	1	0	0	0	0	1	0	0	0	6366	1435	50	5	218	5	GGTLC2	22	22989259	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08		22989259	28315307	177	10810											
PLA2G6	8398	broad.mit.edu	37	chr22	38541510	38541510	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acagccaggtgggccactgaCcagctggggtggttacggat	16	10	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr22:38541510C>G	uc003auy.1	-	3	496	c.360G>C	c.(358-360)TGG>TGC	p.W120C	PLA2G6_uc003auz.1_Missense_Mutation_p.W120C|PLA2G6_uc003ava.1_Missense_Mutation_p.W120C|PLA2G6_uc003avb.2_Missense_Mutation_p.W120C|PLA2G6_uc010gxk.1_Intron|PLA2G6_uc011ano.1_Missense_Mutation_p.W120C	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	120					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	GGGCCACTGACCAGCTGGGGT	0.577													G	38541510	G	G	38541510	3	3	153	1	0	0	0	0	1	0	0	0	12008	508	18	5	2120	5	PLA2G6	22	38541510	Missense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	15552251	38541510	12763056	178	10811											
RANGAP1	5905	broad.mit.edu	37	chr22	41652054	41652054	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gccagcaccttggccatgttGaagccctccagcacctcctg	9	17	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr22:41652054G>T	uc003azs.2	-	9	2514	c.1044C>A	c.(1042-1044)TTC>TTA	p.F348L	RANGAP1_uc003azt.2_Missense_Mutation_p.F348L|RANGAP1_uc003azu.2_Missense_Mutation_p.F348L|RANGAP1_uc011aoz.1_Missense_Mutation_p.F293L	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	348					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						TGGCCATGTTGAAGCCCTCCA	0.552													T	41652054	T	T	41652054	3	4	153	1	0	0	0	0	1	0	0	0	13033	1281	45	5	747	5	RANGAP1	22	41652054	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	3110544	41652054	9652512	179	10812											
SBF1	6305	broad.mit.edu	37	chr22	50904674	50904674	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctgagccggcaggatggGcacataggtgaagctgtgca	16	9	0	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chr22:50904674G>A	uc003blh.2	-	8	997	c.802C>T	c.(802-804)CCC>TCC	p.P268S	SBF1_uc011arx.1_5'UTR|SBF1_uc003bli.2_Missense_Mutation_p.P269S	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	268	DENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GGCAGGATGGGCACATAGGTG	0.672													A	50904674	A	A	50904674	3	1	153	1	0	0	0	0	1	0	0	0	13858	1203	42	3	5015	3	SBF1	22	50904674	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	9252620	50904674	399892	180	10813											
NLGN4X	57502	broad.mit.edu	37	chrX	5811228	5811228	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctttttgtagtacagcgccGcaaaagctaagatgttgagg	11	8	0	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:5811228G>A	uc010ndh.2	-	6	2582	c.2081C>T	c.(2080-2082)GCG>GTG	p.A694V	NLGN4X_uc004crp.2_Missense_Mutation_p.A714V|NLGN4X_uc004crq.2_Missense_Mutation_p.A694V|NLGN4X_uc010ndi.2_Missense_Mutation_p.A731V|NLGN4X_uc004crr.2_Missense_Mutation_p.A694V|NLGN4X_uc010ndj.2_Missense_Mutation_p.A694V	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	694	Helical; (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GTACAGCGCCGCAAAAGCTAA	0.502													A	5811228	A	A	5811228	3	1	153	1	0	0	0	0	1	0	0	0	10464	1087	38	1	373	1	NLGN4X	23	5811228	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08		5811228	149459332	181	10814											
VCX3B	425054	broad.mit.edu	37	chrX	8433516	8433516	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtccaaagccgagagcctcgGgacctccggccaaggccaag	13	15	0	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:8433516G>T	uc010ndo.2	+	2	332	c.25G>T	c.(25-27)GGA>TGA	p.G9*	VCX3B_uc011mht.1_Nonsense_Mutation_p.G9*|VCX3B_uc004csd.1_Nonsense_Mutation_p.G9*	NM_001001888	NP_001001888	Q9H321	VCX3B_HUMAN	variable charge, X-linked 3B	9						nucleolus					0						GAGAGCCTCGGGACCTCCGGC	0.607													T	8433516	T	T	8433516	4	4	153	1	0	0	0	0	0	1	0	0	17142	1233	43	5	27	5	VCX3B	23	8433516	Nonsense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	2622288	8433516	146837044	182	10815											
DMD	1756	broad.mit.edu	37	chrX	32503062	32503062	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtagctctttctctctggccTgcacatcagaaaagacttgc	8	12	4	2			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:32503062T>C	uc004dda.1	-	21	3021	c.2777A>G	c.(2776-2778)CAG>CGG	p.Q926R	DMD_uc004dcz.2_Missense_Mutation_p.Q803R|DMD_uc004dcy.1_Missense_Mutation_p.Q922R|DMD_uc004ddb.1_Missense_Mutation_p.Q918R|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	926	Spectrin 5.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTCTCTGGCCTGCACATCAGA	0.408													C	32503062	C	C	32503062	3	2	153	1	0	0	0	0	1	0	0	0	4580	1580	55	4	8759	4	DMD	23	32503062	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	24069546	32503062	122767498	183	10816											
CXorf22	170063	broad.mit.edu	37	chrX	36007487	36007487	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaagtaacttggcagcaggGcttcagttctccagaagaag	12	8	2	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:36007487G>A	uc004ddj.2	+	16	2824	c.2765G>A	c.(2764-2766)GGC>GAC	p.G922D	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	922										large_intestine(1)|lung(1)|ovary(1)	3						TGGCAGCAGGGCTTCAGTTCT	0.368													A	36007487	A	A	36007487	3	1	153	1	0	0	0	0	1	0	0	0	4102	1203	42	3	2827	3	CXorf22	23	36007487	Missense_Mutation	SNP	G	TCGA-19-1790-01B-01D-1353-08	3504425	36007487	119263073	184	10817											
ZC4H2	55906	broad.mit.edu	37	chrX	64140054	64140054	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccacatgttctttcagtggcTtatactcatcatgcagcctc	6	13	4	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:64140054T>C	uc004dvu.2	-	3	393	c.305A>G	c.(304-306)AAG>AGG	p.K102R	ZC4H2_uc004dvv.2_Missense_Mutation_p.K79R|ZC4H2_uc011mov.1_Missense_Mutation_p.K79R|ZC4H2_uc011mow.1_Missense_Mutation_p.K102R|ZC4H2_uc004dvw.1_Missense_Mutation_p.K102R	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	102	Potential.						metal ion binding|protein binding			ovary(1)	1						TTTCAGTGGCTTATACTCATC	0.473													C	64140054	C	C	64140054	3	2	153	1	0	0	0	0	1	0	0	0	17575	1609	56	4	400	4	ZC4H2	23	64140054	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	28132567	64140054	91130506	185	10818											
EDA	1896	broad.mit.edu	37	chrX	69250324	69250324	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttctcatcctgccagccagcTgtggtgcatctacagggcca	10	14	2	0			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:69250324T>C	uc004dxs.2	+	6	989	c.747T>C	c.(745-747)GCT>GCC	p.A249A	EDA_uc004dxr.2_Silent_p.A249A|EDA_uc011mpj.1_Silent_p.A249A	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	249	Extracellular (Potential).				cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						GCCAGCCAGCTGTGGTGCATC	0.502											OREG0019846	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	69250324	C	C	69250324	2	2	153	1	0	0	0	0	0	0	0	1	4903	1567	55	4		4	EDA	23	69250324	Silent	SNP	T	TCGA-19-1790-01B-01D-1353-08	5110270	69250324	86020236	186	10819											
CDX4	1046	broad.mit.edu	37	chrX	72674301	72674301	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgagaatagtggaggctcGgtgcaaagtgactctgactc	13	7	1	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:72674301G>A	uc011mqk.1	+	3	735	c.735G>A	c.(733-735)TCG>TCA	p.S245S		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					GTGGAGGCTCGGTGCAAAGTG	0.448													A	72674301	A	A	72674301	2	1	153	1	0	0	0	0	0	0	0	1	3184	1103	39	2		2	CDX4	23	72674301	Silent	SNP	G	TCGA-19-1790-01B-01D-1353-08	3423977	72674301	82596259	187	10820											
RLIM	51132	broad.mit.edu	37	chrX	73811531	73811531	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctctaggttggtcatcatcaTcctcatttaagaggaaaaac	7	9	5	1			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:73811531T>C	uc004ebu.2	-	5	1909	c.1619A>G	c.(1618-1620)GAT>GGT	p.D540G	RLIM_uc004ebw.2_Missense_Mutation_p.D540G	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	540					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GTCATCATCATCCTCATTTAA	0.458													C	73811531	C	C	73811531	3	2	153	1	0	0	0	0	1	0	0	0	13390	1435	50	4	259	4	RLIM	23	73811531	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	1137230	73811531	81459029	188	10821											
CYLC1	1538	broad.mit.edu	37	chrX	83128534	83128534	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gaattactcacagaataattCaaagaattattctttgaagt	5	5	3	3			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:83128534C>G	uc004eei.1	+	4	839	c.818C>G	c.(817-819)TCA>TGA	p.S273*	CYLC1_uc004eeh.1_Nonsense_Mutation_p.S272*	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	273					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						CAGAATAATTCAAAGAATTAT	0.318													G	83128534	G	G	83128534	4	3	153	1	0	0	0	0	0	1	0	0	4141	838	29	5	832	5	CYLC1	23	83128534	Nonsense_Mutation	SNP	C	TCGA-19-1790-01B-01D-1353-08	9317003	83128534	72142026	189	10822											
RPS6KA6	27330	broad.mit.edu	37	chrX	83361995	83361995	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatagaagttgcaacaaagcTgaatcctttgaagagctgat	9	6	0	5			TCGA-19-1790-01B-01D-1353-08	TCGA-19-1790-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	081e73fe-86ff-4337-be06-3b5cb9759945	287a5160-5729-4ad5-980f-d50fb4769b22	g.chrX:83361995T>C	uc004eej.1	-	14	1242	c.1165A>G	c.(1165-1167)AGC>GGC	p.S389G	RPS6KA6_uc011mqt.1_Missense_Mutation_p.S389G|RPS6KA6_uc011mqu.1_Missense_Mutation_p.S286G	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	389	AGC-kinase C-terminal.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						GCAACAAAGCTGAATCCTTTG	0.343													C	83361995	C	C	83361995	3	2	153	1	0	0	0	0	1	0	0	0	13655	1580	55	4	1108	4	RPS6KA6	23	83361995	Missense_Mutation	SNP	T	TCGA-19-1790-01B-01D-1353-08	233461	83361995	71908565	190	10823											
HFM1	164045	broad.mit.edu	37	chr1	91843657	91843657	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtgctggtattttttaaagtCtgagaaacagactgtacagt	10	5	1	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:91843657C>T	uc001doa.3	-	11	1420	c.1320G>A	c.(1318-1320)CAG>CAA	p.Q440Q	HFM1_uc010osu.1_Silent_p.Q119Q|HFM1_uc010osv.1_Silent_p.Q124Q|HFM1_uc001doc.1_Silent_p.Q440Q	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	440	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TTTTTAAAGTCTGAGAAACAG	0.368													T	91843657	T	T	91843657	2	4	154	1	0	0	0	0	0	0	0	1	7083	912	32	3		3	HFM1	1	91843657	Silent	SNP	C	TCGA-19-2619-01A-01D-1495-08		91843657	157406964	1	10824											
LINGO4	339398	broad.mit.edu	37	chr1	151774511	151774511	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagctgccccagcccccgcaGggccccagctggcagcctcc	12	21	0	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:151774511G>A	uc001ezf.1	-	2	860	c.670C>T	c.(670-672)CTG>TTG	p.L224L		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	224	Extracellular (Potential).|LRR 7.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGCCCCCGCAGGGCCCCAGCT	0.642													A	151774511	A	A	151774511	2	1	154	1	0	0	0	0	0	0	0	1	8817	991	35	3		3	LINGO4	1	151774511	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08	59930854	151774511	97476110	2	10825											
UBQLN4	56893	broad.mit.edu	37	chr1	156011962	156011962	+	Silent	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	acctgctgcaggaagactggGagctgcaggcggagctgctc	16	11	0	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:156011962G>C	uc001fna.2	-	8	1356	c.1332C>G	c.(1330-1332)CTC>CTG	p.L444L	UBQLN4_uc010pgx.1_Silent_p.L424L	NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	444						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)|skin(1)	2	Hepatocellular(266;0.133)|all_neural(408;0.195)					GGAAGACTGGGAGCTGCAGGC	0.617													C	156011962	C	C	156011962	2	2	154	1	0	0	0	0	0	0	0	1	16896	1161	41	5		5	UBQLN4	1	156011962	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08	4237451	156011962	93238659	3	10826											
UBQLN4	56893	broad.mit.edu	37	chr1	156021545	156021545	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cagtgagcccgtccttgattCcgtgctggttcagtgtgtcc	12	12	1	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:156021545C>G	uc001fna.2	-	2	236	c.212G>C	c.(211-213)GGA>GCA	p.G71A	UBQLN4_uc010pgx.1_Missense_Mutation_p.G71A|ROBLD3_uc001fnb.3_5'Flank|ROBLD3_uc010pgy.1_5'Flank	NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	71	Ubiquitin-like.					cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)|skin(1)	2	Hepatocellular(266;0.133)|all_neural(408;0.195)					GTCCTTGATTCCGTGCTGGTT	0.537													G	156021545	G	G	156021545	3	3	154	1	0	0	0	0	1	0	0	0	16896	855	30	5	1633	5	UBQLN4	1	156021545	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	9583	156021545	93229076	4	10827											
IQGAP3	128239	broad.mit.edu	37	chr1	156501015	156501015	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tccccaggatggaactgtatGatatcggccaacagctgctt	10	11	0	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:156501015G>C	uc001fpf.2	-	33	4203	c.4128C>G	c.(4126-4128)ATC>ATG	p.I1376M		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1376					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGAACTGTATGATATCGGCCA	0.587													C	156501015	C	C	156501015	3	2	154	1	0	0	0	0	1	0	0	0	7816	1280	45	5	791	5	IQGAP3	1	156501015	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	479470	156501015	92749606	5	10828											
NTRK1	4914	broad.mit.edu	37	chr1	156834161	156834161	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagctacatcgagaaccaGcagcatctgcagcatctgga	9	13	2	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:156834161G>A	uc001fqh.1	+	2	284	c.228G>A	c.(226-228)CAG>CAA	p.Q76Q	NTRK1_uc001fqf.1_Silent_p.Q46Q|NTRK1_uc009wsi.1_5'UTR|NTRK1_uc001fqi.1_Silent_p.Q76Q|NTRK1_uc009wsk.1_Silent_p.Q76Q	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	76	Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TCGAGAACCAGCAGCATCTGC	0.587			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			A	156834161	A	A	156834161	2	1	154	1	0	0	0	0	0	0	0	1	10706	962	34	3		3	NTRK1	1	156834161	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08	333146	156834161	92416460	6	10829											
ARHGEF11	9826	broad.mit.edu	37	chr1	156917714	156917714	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gaggtggggaaggagggtatCtgtgcagaaccccaaactgg	17	7	1	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:156917714C>T	uc001fqo.2	-	24	3108	c.2068G>A	c.(2068-2070)GAT>AAT	p.D690N	ARHGEF11_uc010phu.1_Missense_Mutation_p.D106N|ARHGEF11_uc001fqn.2_Missense_Mutation_p.D730N	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	690					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGGAGGGTATCTGTGCAGAAC	0.562													T	156917714	T	T	156917714	3	4	154	1	0	0	0	0	1	0	0	0	896	913	32	3	2568	3	ARHGEF11	1	156917714	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	83553	156917714	92332907	7	10830											
F5	2153	broad.mit.edu	37	chr1	169489788	169489788	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acaaccttgcagttccaatcGaagggtaggtctgttatagg	11	8	1	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:169489788G>A	uc001ggg.1	-	22	6308	c.6163C>T	c.(6163-6165)CGA>TGA	p.R2055*		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2055	F5/8 type C 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AGTTCCAATCGAAGGGTAGGT	0.403													A	169489788	A	A	169489788	4	1	154	1	0	0	0	0	0	1	0	0	5348	1066	37	2	527	2	F5	1	169489788	Nonsense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	12572074	169489788	79760833	8	10831											
LGR6	59352	broad.mit.edu	37	chr1	202287759	202287759	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gccatggtgaggcacgtggcCtggctcatcttcgcagacgg	15	12	2	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:202287759C>A	uc001gxu.2	+	18	2328	c.2328C>A	c.(2326-2328)GCC>GCA	p.A776A	LGR6_uc001gxv.2_Silent_p.A724A|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.A637A	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	776	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						GGCACGTGGCCTGGCTCATCT	0.637													A	202287759	A	A	202287759	2	1	154	1	0	0	0	0	0	0	0	1	8758	668	24	5		5	LGR6	1	202287759	Silent	SNP	C	TCGA-19-2619-01A-01D-1495-08	32797971	202287759	46962862	9	10832											
RASSF5	83593	broad.mit.edu	37	chr1	206711530	206711530	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacctgtcacccagaatgcCgcagcctgatccagttggac	9	15	2	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:206711530C>T	uc001hed.2	+	2	544	c.487C>T	c.(487-489)CGC>TGC	p.R163C	RASSF5_uc001hec.1_Missense_Mutation_p.R163C|RASSF5_uc001hee.2_Missense_Mutation_p.R163C	NM_182663	NP_872604	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family 5	163	Phorbol-ester/DAG-type.				apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			ovary(1)	1	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CCCAGAATGCCGCAGCCTGAT	0.532													T	206711530	T	T	206711530	3	4	154	1	0	0	0	0	1	0	0	0	13089	652	23	2	493	2	RASSF5	1	206711530	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	4423771	206711530	42539091	10	10833											
MAPKAPK2	9261	broad.mit.edu	37	chr1	206902080	206902080	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaggactgccccaaggcccGcagggaggtggagctgcact	15	13	1	0	rs151079567		TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:206902080G>A	uc001hem.1	+	2	591	c.305G>A	c.(304-306)CGC>CAC	p.R102H	MAPKAPK2_uc001hel.1_Missense_Mutation_p.R102H	NM_032960	NP_116584	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated	102	Protein kinase.				activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			CCCAAGGCCCGCAGGGAGGTG	0.622													A	206902080	A	A	206902080	3	1	154	1	0	0	0	0	1	0	0	0	9289	1087	38	1	311	1	MAPKAPK2	1	206902080	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	190550	206902080	42348541	11	10834											
ESRRG	2104	broad.mit.edu	37	chr1	216737723	216737723	+	Splice_Site	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atgtgagacaatcttgttatCtgcaggatcagaccagagca	10	8	3	3			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr1:216737723C>G	uc001hkw.1	-	5	867	c.701_splice	c.e5-1	p.Y234_splice	ESRRG_uc001hky.1_Splice_Site_p.Y211_splice|ESRRG_uc009xdp.1_Splice_Site_p.Y211_splice|ESRRG_uc001hkz.1_Splice_Site_p.Y172_splice|ESRRG_uc010puc.1_Splice_Site_p.Y211_splice|ESRRG_uc001hla.1_Splice_Site_p.Y211_splice|ESRRG_uc001hlb.1_Splice_Site_p.Y211_splice|ESRRG_uc010pud.1_Splice_Site_p.Y42_splice|ESRRG_uc001hlc.1_Splice_Site_p.Y211_splice|ESRRG_uc001hld.1_Splice_Site_p.Y211_splice|ESRRG_uc001hkx.1_Missense_Mutation_p.D246H|ESRRG_uc009xdo.1_Splice_Site_p.Y211_splice|ESRRG_uc001hle.1_Splice_Site_p.Y211_splice	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1						positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	ATCTTGTTATCTGCAGGATCA	0.433													G	216737723	G	G	216737723	5	3	154	1	0	0	0	0	0	0	1	0	5262	927	32	5	688	5	ESRRG	1	216737723	Splice_Site	SNP	C	TCGA-19-2619-01A-01D-1495-08	9835643	216737723	32512898	12	10835											
TSSC1	7260	broad.mit.edu	37	chr2	3193249	3193249	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcgtgctcctcgtaggtggcGatcacgttgtcctgcagggg	15	11	1	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr2:3193249G>A	uc002qxj.2	-	9	1213	c.1020C>T	c.(1018-1020)ATC>ATT	p.I340I	TSSC1_uc002qxi.2_RNA	NM_003310	NP_003301	Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	340							protein binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		CGTAGGTGGCGATCACGTTGT	0.657													A	3193249	A	A	3193249	2	1	154	1	0	0	0	0	0	0	0	1	16663	1048	37	2		2	TSSC1	2	3193249	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08		3193249	240006124	13	10836											
MAP4K4	9448	broad.mit.edu	37	chr2	102486218	102486218	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgatgtggagcaggaaggGgctgacgagtccacctcagg	17	9	1	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr2:102486218G>A	uc002tbg.2	+	20	2410	c.2355G>A	c.(2353-2355)GGG>GGA	p.G785G	MAP4K4_uc002tbc.2_Silent_p.G866G|MAP4K4_uc002tbd.2_Silent_p.G758G|MAP4K4_uc002tbe.2_Silent_p.G704G|MAP4K4_uc002tbf.2_Silent_p.G755G|MAP4K4_uc010yvy.1_Silent_p.G781G|MAP4K4_uc002tbh.2_Silent_p.G703G|MAP4K4_uc002tbi.2_Silent_p.G588G|MAP4K4_uc010yvz.1_Silent_p.G761G|MAP4K4_uc002tbk.2_Silent_p.G240G|MAP4K4_uc002tbl.2_5'UTR	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	785					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AGCAGGAAGGGGCTGACGAGT	0.572													A	102486218	A	A	102486218	2	1	154	1	0	0	0	0	0	0	0	1	9262	1219	43	3		3	MAP4K4	2	102486218	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08	99292969	102486218	140713155	14	10837											
ALS2CR8	79800	broad.mit.edu	37	chr2	203806678	203806678	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ccataatgacggtgaagagtCaaaaaccagtgctcaagtat	9	8	2	3			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr2:203806678C>T	uc002uzo.2	+	3	333	c.53C>T	c.(52-54)TCA>TTA	p.S18L	ALS2CR8_uc002uzn.2_Intron|ALS2CR8_uc002uzm.2_Missense_Mutation_p.S18L|ALS2CR8_uc010zhy.1_Missense_Mutation_p.S18L|ALS2CR8_uc010zhz.1_Intron|ALS2CR8_uc010ftu.1_Intron|ALS2CR8_uc010zia.1_Missense_Mutation_p.S18L|ALS2CR8_uc010zib.1_Missense_Mutation_p.S18L|ALS2CR8_uc010zic.1_Intron|ALS2CR8_uc002uzp.2_Missense_Mutation_p.S18L	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	18										large_intestine(1)|ovary(1)	2						GGTGAAGAGTCAAAAACCAGT	0.363													T	203806678	T	T	203806678	3	4	154	1	0	0	0	0	1	0	0	0	555	838	29	3	55	3	ALS2CR8	2	203806678	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	101320460	203806678	39392695	15	10838											
ABI3BP	25890	broad.mit.edu	37	chr3	100568897	100568897	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcattagttaccaggtgtcGtaggctgcatttctggactg	12	8	2	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr3:100568897G>A	uc003dun.2	-	15	1452	c.1367C>T	c.(1366-1368)ACG>ATG	p.T456M	ABI3BP_uc003duo.2_Missense_Mutation_p.T498M	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	456	Pro-rich.					extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						ACCAGGTGTCGTAGGCTGCAT	0.378													A	100568897	A	A	100568897	3	1	154	1	0	0	0	0	1	0	0	0	91	1145	40	1	1944	1	ABI3BP	3	100568897	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08		100568897	97453533	16	10839											
MYH15	22989	broad.mit.edu	37	chr3	108205332	108205332	+	Frame_Shift_Del	DEL	A	-	-													agtaactgctccacaggagcAaaagtggaagtctgagggat							TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr3:108205332delA	uc003dxa.1	-	11	1030	c.973delT	c.(973-975)TGCfs	p.C325fs		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	325	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CCACAGGAGCAAAAGTGGAAG	0.438													-	108205332	-	-	108205332	7	5	154	1	0	1	0	1	0	0	0	0	10034	130	5	0	4995	0	MYH15	3	108205332	Frame_Shift_Del	DEL	A	TCGA-19-2619-01A-01D-1495-08	7636435	108205332	89817098	17	10840											
ZIC1	7545	broad.mit.edu	37	chr3	147128425	147128425	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggacatgtacccgcgaccgGagcagtacggccaggtgacc	15	13	0	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr3:147128425G>A	uc003ewe.2	+	1	1245	c.526G>A	c.(526-528)GAG>AAG	p.E176K		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	176					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCCGCGACCGGAGCAGTACGG	0.682													A	147128425	A	A	147128425	3	1	154	1	0	0	0	0	1	0	0	0	17675	1175	41	3	528	3	ZIC1	3	147128425	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	38923093	147128425	50894005	18	10841											
POU4F2	5458	broad.mit.edu	37	chr4	147561770	147561770	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caatggcgcggagaagaagcGcaagcgcacgtccatcgctg	14	12	0	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr4:147561770G>A	uc003ikv.2	+	2	1288	c.1040G>A	c.(1039-1041)CGC>CAC	p.R347H		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	347	Homeobox.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					GAGAAGAAGCGCAAGCGCACG	0.622													A	147561770	A	A	147561770	3	1	154	1	0	0	0	0	1	0	0	0	12279	1087	38	1	1046	1	POU4F2	4	147561770	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08		147561770	43592506	19	10842											
ZDHHC11	79844	broad.mit.edu	37	chr5	825284	825284	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgactgcaacttacccgtgCcgtcgaatccccatcctggt	9	15	0	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr5:825284C>T	uc011cma.1	-	8	1402	c.1018G>A	c.(1018-1020)GCA>ACA	p.A340T	ZDHHC11_uc010itc.2_5'Flank|ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	340						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			CTTACCCGTGCCGTCGAATCC	0.542													T	825284	T	T	825284	3	4	154	1	0	0	0	0	1	0	0	0	17598	739	26	3	240	3	ZDHHC11	5	825284	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08		825284	180089976	20	10843											
HTR1A	3350	broad.mit.edu	37	chr5	63257205	63257205	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcagcacagcacgtcgagGgcgatgaacaggtcgcaggt	16	10	0	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr5:63257205G>A	uc011cqt.1	-	1	342	c.342C>T	c.(340-342)GCC>GCT	p.A114A		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	114	Helical; Name=3; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCACGTCGAGGGCGATGAACA	0.607													A	63257205	A	A	63257205	2	1	154	1	0	0	0	0	0	0	0	1	7436	1219	43	3		3	HTR1A	5	63257205	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08	62431921	63257205	117658055	21	10844											
PCDHA5	56143	broad.mit.edu	37	chr5	140203141	140203141	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacgtggtggcgaaggtgcGcgcagtggaccctgattcgg	17	11	0	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr5:140203141G>A	uc003lhl.2	+	1	1781	c.1781G>A	c.(1780-1782)CGC>CAC	p.R594H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R594H|PCDHA5_uc003lhj.1_Missense_Mutation_p.R594H	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	594	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAAGGTGCGCGCAGTGGAC	0.697													A	140203141	A	A	140203141	3	1	154	1	0	0	0	0	1	0	0	0	11527	1087	38	1	1783	1	PCDHA5	5	140203141	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	76945936	140203141	40712119	22	10845											
RGS14	10636	broad.mit.edu	37	chr5	176794018	176794018	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agccccggccggacatgtttCgggcacagcagcttcaggtg	14	13	1	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr5:176794018C>A	uc003mgf.2	+	5	648	c.466C>A	c.(466-468)CGG>AGG	p.R156R	RGS14_uc003mgg.1_Silent_p.R3R|RGS14_uc003mgh.2_Silent_p.R3R|RGS14_uc003mgi.2_5'Flank	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	156	RGS.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGACATGTTTCGGGCACAGCA	0.662													A	176794018	A	A	176794018	2	1	154	1	0	0	0	0	0	0	0	1	13297	875	31	5		5	RGS14	5	176794018	Silent	SNP	C	TCGA-19-2619-01A-01D-1495-08	36590877	176794018	4121242	23	10846											
PTK7	5754	broad.mit.edu	37	chr6	43109925	43109925	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gacaggatgcacatcttccaGaatggctccctggtgatcca	10	12	1	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr6:43109925G>A	uc003oub.1	+	13	2133	c.1935G>A	c.(1933-1935)CAG>CAA	p.Q645Q	PTK7_uc003ouc.1_Intron|PTK7_uc003oud.1_Silent_p.Q605Q|PTK7_uc003oue.1_Silent_p.Q515Q|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.Q653Q|PTK7_uc010jyj.1_Intron	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	645	Ig-like C2-type 7.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			ACATCTTCCAGAATGGCTCCC	0.642													A	43109925	A	A	43109925	2	1	154	1	0	0	0	0	0	0	0	1	12765	933	33	3		3	PTK7	6	43109925	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08		43109925	128005142	24	10847											
SRF	6722	broad.mit.edu	37	chr6	43141721	43141721	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcaaggcactgattcagaCctgcctcaactcgccagact	9	15	2	3			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr6:43141721C>T	uc003oui.2	+	2	1125	c.650C>T	c.(649-651)ACC>ATC	p.T217I	SRF_uc011dvf.1_Missense_Mutation_p.T13I	NM_003131	NP_003122	P11831	SRF_HUMAN	serum response factor (c-fos serum response	217	|Involved in dimerization.				angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			ovary(1)|breast(1)|central_nervous_system(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CTGATTCAGACCTGCCTCAAC	0.557													T	43141721	T	T	43141721	3	4	154	1	0	0	0	0	1	0	0	0	15142	507	18	3	656	3	SRF	6	43141721	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	31796	43141721	127973346	25	10848											
DST	667	broad.mit.edu	37	chr6	56566691	56566691	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaaaacatcatacctggcGtcttttcaaatagtcaagtg	6	9	5	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr6:56566691G>A	uc003pdf.2	-	7	878	c.850C>T	c.(850-852)CGC>TGC	p.R284C	DST_uc003pcz.3_Missense_Mutation_p.R106C|DST_uc011dxj.1_Missense_Mutation_p.R135C|DST_uc011dxk.1_Missense_Mutation_p.R146C|DST_uc011dxl.1_Missense_Mutation_p.R135C	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	106	CH 1.|Actin-binding.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CATACCTGGCGTCTTTTCAAA	0.343													A	56566691	A	A	56566691	3	1	154	1	0	0	0	0	1	0	0	0	4783	1160	40	1		1	DST	6	56566691	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	13424970	56566691	114548376	26	10849											
PLG	5340	broad.mit.edu	37	chr6	161127557	161127557	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcaaaatgtgaggaggaCgaagaattcacctgcaggta	13	7	1	2	rs144100362		TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr6:161127557C>T	uc003qtm.3	+	2	231	c.168C>T	c.(166-168)GAC>GAT	p.D56D		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	56	PAN.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GTGAGGAGGACGAAGAATTCA	0.413													T	161127557	T	T	161127557	2	4	154	1	0	0	0	0	0	0	0	1	12086	535	19	1		1	PLG	6	161127557	Silent	SNP	C	TCGA-19-2619-01A-01D-1495-08	104560866	161127557	9987510	27	10850											
ZNF107	51427	broad.mit.edu	37	chr7	64168371	64168371	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catggcaaagtttttaaccaGtcctcaaaccttactacaca	4	12	1	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr7:64168371G>A	uc003ttd.2	+	7	2475	c.1689G>A	c.(1687-1689)CAG>CAA	p.Q563Q	ZNF107_uc003tte.2_Silent_p.Q563Q	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	563	C2H2-type 18; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TTTTTAACCAGTCCTCAAACC	0.348													A	64168371	A	A	64168371	2	1	154	1	0	0	0	0	0	0	0	1	17712	1020	36	3		3	ZNF107	7	64168371	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08		64168371	94970292	28	10851											
PCLO	27445	broad.mit.edu	37	chr7	82581607	82581607	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcagtgattccctgggataCggtgctatcagtccatccat	9	11	2	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr7:82581607C>T	uc003uhx.2	-	5	8951	c.8662G>A	c.(8662-8664)GTA>ATA	p.V2888I	PCLO_uc003uhv.2_Missense_Mutation_p.V2888I|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2819					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CCCTGGGATACGGTGCTATCA	0.463													T	82581607	T	T	82581607	3	4	154	1	0	0	0	0	1	0	0	0	11583	536	19	1	6867	1	PCLO	7	82581607	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	18413236	82581607	76557056	29	10852											
COL1A2	1278	broad.mit.edu	37	chr7	94043012	94043012	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atatttttagggtgctccagGtcctgatggaaacaatggtg	12	6	0	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr7:94043012G>T	uc003ung.1	+	27	2039	c.1568G>T	c.(1567-1569)GGT>GTT	p.G523V	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	523					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGTGCTCCAGGTCCTGATGGA	0.438										HNSCC(75;0.22)			T	94043012	T	T	94043012	3	4	154	1	0	0	0	0	1	0	0	0	3678	1261	44	5	1674	5	COL1A2	7	94043012	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	11461405	94043012	65095651	30	10853											
INTS10	55174	broad.mit.edu	37	chr8	19690804	19690804	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcgctcatccagctggcgaCgtgccactttgcgctagggg	15	13	1	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr8:19690804C>T	uc003wzj.2	+	12	1633	c.1502C>T	c.(1501-1503)ACG>ATG	p.T501M		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	501					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		CAGCTGGCGACGTGCCACTTT	0.602													T	19690804	T	T	19690804	3	4	154	1	0	0	0	0	1	0	0	0	7776	536	19	1	1548	1	INTS10	8	19690804	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08		19690804	126673218	31	10854											
ENPP2	5168	broad.mit.edu	37	chr8	120598445	120598445	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttgcaacatgccatctgcGttccaccaataaatggatat	6	12	1	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr8:120598445G>A	uc003yot.1	-	15	1434	c.1348C>T	c.(1348-1350)CGC>TGC	p.R450C	ENPP2_uc011lic.1_5'Flank|ENPP2_uc003yor.1_Missense_Mutation_p.R89C|ENPP2_uc003yos.1_Missense_Mutation_p.R502C|ENPP2_uc010mdd.1_Missense_Mutation_p.R450C	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	450					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGCCATCTGCGTTCCACCAAT	0.413													A	120598445	A	A	120598445	3	1	154	1	0	0	0	0	1	0	0	0	5130	1145	40	1	1366	1	ENPP2	8	120598445	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	100907641	120598445	25765577	32	10855											
IFNB1	3456	broad.mit.edu	37	chr9	21077338	21077338	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	taacctgtaagtctgttaatGaagtaaaagttccttaggat	8	5	1	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr9:21077338G>A	uc003zok.2	-	1	606	c.531C>T	c.(529-531)TTC>TTT	p.F177F		NM_002176	NP_002167	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast precursor	177					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			ovary(1)|breast(1)|kidney(1)	3				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)	GTCTGTTAATGAAGTAAAAGT	0.453													A	21077338	A	A	21077338	2	1	154	1	0	0	0	0	0	0	0	1	7546	1281	45	3		3	IFNB1	9	21077338	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08		21077338	120136093	33	10856											
AKR1E2	83592	broad.mit.edu	37	chr10	4873008	4873008	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaaggaaggcgctgtaagaCgggaggatctgttcattgcc	14	8	3	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr10:4873008C>T	uc001ihi.2	+	2	296	c.181C>T	c.(181-183)CGG>TGG	p.R61W	AKR1E2_uc001ihl.1_RNA|AKR1E2_uc010qam.1_Missense_Mutation_p.R61W|AKR1E2_uc001ihh.1_Missense_Mutation_p.R61W|AKR1E2_uc009xhw.2_Missense_Mutation_p.R61W|AKR1E2_uc001ihj.2_RNA|AKR1E2_uc001ihk.2_Missense_Mutation_p.R61W	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	61						cytoplasm	1,5-anhydro-D-fructose reductase activity				0						CGCTGTAAGACGGGAGGATCT	0.507													T	4873008	T	T	4873008	3	4	154	1	0	0	0	0	1	0	0	0	474	527	19	1	187	1	AKR1E2	10	4873008	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08		4873008	130661739	34	10857											
ITIH2	3698	broad.mit.edu	37	chr10	7762869	7762869	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgagatttcttcatgttccCgacacatttgaaggccattt	7	10	2	2	rs144114794		TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr10:7762869C>T	uc001ijs.2	+	7	843	c.681C>T	c.(679-681)CCC>CCT	p.P227P		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	227					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TTCATGTTCCCGACACATTTG	0.453													T	7762869	T	T	7762869	2	4	154	1	0	0	0	0	0	0	0	1	7904	639	23	2		2	ITIH2	10	7762869	Silent	SNP	C	TCGA-19-2619-01A-01D-1495-08	2889861	7762869	127771878	35	10858											
C10orf68	79741	broad.mit.edu	37	chr10	33000595	33000595	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctatgcttaaacatcaagatTcagtgtcaaaaatccaagtg	6	8	3	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr10:33000595T>C	uc001iwn.3	+	7	900	c.427T>C	c.(427-429)TCA>CCA	p.S143P	C10orf68_uc001iwl.1_Missense_Mutation_p.S151P|C10orf68_uc001iwm.1_Missense_Mutation_p.S119P|C10orf68_uc010qei.1_Missense_Mutation_p.S70P	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	143										skin(2)|ovary(1)	3						ACATCAAGATTCAGTGTCAAA	0.308													C	33000595	C	C	33000595	3	2	154	1	0	0	0	0	1	0	0	0	1613	1783	62	4	445	4	C10orf68	10	33000595	Missense_Mutation	SNP	T	TCGA-19-2619-01A-01D-1495-08	25237726	33000595	102534152	36	10859											
NAV3	89795	broad.mit.edu	37	chr12	78591133	78591133	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	taatcttcatcatgtgggctCtctgagtgatatcttcaatg	8	8	6	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr12:78591133C>G	uc001syp.2	+	35	6571	c.6398C>G	c.(6397-6399)TCT>TGT	p.S2133C	NAV3_uc001syo.2_Missense_Mutation_p.S2111C|NAV3_uc010sub.1_Missense_Mutation_p.S1590C|NAV3_uc009zsf.2_Missense_Mutation_p.S942C	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2133						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CATGTGGGCTCTCTGAGTGAT	0.328										HNSCC(70;0.22)			G	78591133	G	G	78591133	3	3	154	1	0	0	0	0	1	0	0	0	10185	913	32	5	6466	5	NAV3	12	78591133	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08		78591133	55260762	37	10860											
PAWR	5074	broad.mit.edu	37	chr12	80014954	80014954	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcgtttccgctctttctGccctgcttcatcatcttcgt	5	15	6	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr12:80014954G>A	uc001syx.2	-	3	836	c.550C>T	c.(550-552)CAG>TAG	p.Q184*		NM_002583	NP_002574	Q96IZ0	PAWR_HUMAN	PRKC, apoptosis, WT1, regulator	184	Selective for apoptosis induction in cancer cells (SAC).				actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0						CGCTCTTTCTGCCCTGCTTCA	0.363													A	80014954	A	A	80014954	4	1	154	1	0	0	0	0	0	1	0	0	11477	1328	46	3	492	3	PAWR	12	80014954	Nonsense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	1423821	80014954	53836941	38	10861											
FRY	10129	broad.mit.edu	37	chr13	32735289	32735289	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttctaattctaggggtgagaGaaagccaaaaatagatcttt	9	5	3	3			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr13:32735289G>A	uc001utx.2	+	17	2289	c.1793G>A	c.(1792-1794)AGA>AAA	p.R598K	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AGGGGTGAGAGAAAGCCAAAA	0.299													A	32735289	A	A	32735289	3	1	154	1	0	0	0	0	1	0	0	0	6063	942	33	3	1859	3	FRY	13	32735289	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08		32735289	82434589	39	10862											
FARP1	10160	broad.mit.edu	37	chr13	99042246	99042246	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttggaattcctgatggcCagtcgggatttctgcaagtc	11	10	1	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr13:99042246C>T	uc001vnj.2	+	10	1227	c.891C>T	c.(889-891)GCC>GCT	p.A297A	FARP1_uc001vnh.2_Silent_p.A297A	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	297	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TCCTGATGGCCAGTCGGGATT	0.443													T	99042246	T	T	99042246	2	4	154	1	0	0	0	0	0	0	0	1	5676	581	21	3		3	FARP1	13	99042246	Silent	SNP	C	TCGA-19-2619-01A-01D-1495-08	66306957	99042246	16127632	40	10863											
KIAA1409	57578	broad.mit.edu	37	chr14	94041533	94041533	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtgaactggcagggaaccttGcatctcgaagggtaattatt	12	7	1	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr14:94041533G>C	uc001ybv.1	+	14	1752	c.1669G>C	c.(1669-1671)GCA>CCA	p.A557P	KIAA1409_uc001ybs.1_Missense_Mutation_p.A557P	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	734						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AGGGAACCTTGCATCTCGAAG	0.373													C	94041533	C	C	94041533	3	2	154	1	0	0	0	0	1	0	0	0	8230	1319	46	5	1723	5	KIAA1409	14	94041533	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08		94041533	13308007	41	10864											
CHD2	1106	broad.mit.edu	37	chr15	93567832	93567834	+	In_Frame_Del	DEL	CTC	-	-													ctcacccccttctcagaaatCtcctcacgattccaagtcac							TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr15:93567832_93567834delCTC	uc002bsp.2	+	39	5959_5961	c.5384_5386delCTC	c.(5383-5388)TCTCCT>TCT	p.P1796del		NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1796					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TCTCAGAAATCTCCTCACGATTC	0.468													-	93567834	-	-	93567832	7	5	154	1	0	1	0	1	0	0	0	0	3325	913	32	0	5538	0	CHD2	15	93567832	In_Frame_Del	DEL	CTC	TCGA-19-2619-01A-01D-1495-08		93567832	8963560	42	10865											
UBFD1	56061	broad.mit.edu	37	chr16	23570883	23570883	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtgaccagtggggccaagatCatggtggttggctccaccat	14	10	1	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr16:23570883C>T	uc002dlv.2	+	3	652	c.450C>T	c.(448-450)ATC>ATT	p.I150I	EARS2_uc002dls.3_5'Flank|EARS2_uc002dlt.3_5'Flank|EARS2_uc002dlu.2_5'Flank	NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	150	Ubiquitin-like.										0				GBM - Glioblastoma multiforme(48;0.0331)		GGGCCAAGATCATGGTGGTTG	0.502													T	23570883	T	T	23570883	2	4	154	1	0	0	0	0	0	0	0	1	16881	816	29	3		3	UBFD1	16	23570883	Silent	SNP	C	TCGA-19-2619-01A-01D-1495-08		23570883	66783870	43	10866											
RNMTL1	55178	broad.mit.edu	37	chr17	695048	695048	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagccagtcaagattggctGcctcatgttgaggttcagag	14	8	3	3			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr17:695048G>A	uc002frw.2	+	4	1108	c.1002G>A	c.(1000-1002)CTG>CTA	p.L334L		NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	334					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		AAGATTGGCTGCCTCATGTTG	0.552													A	695048	A	A	695048	2	1	154	1	0	0	0	0	0	0	0	1	13507	1306	46	3		3	RNMTL1	17	695048	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08		695048	80500162	44	10867											
ALDH3A1	218	broad.mit.edu	37	chr17	19641725	19641725	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcggcggtgagagaaagtctCgaagctcttcttgccatggt	14	9	3	2	rs113168621		TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr17:19641725C>T	uc010cqu.2	-	9	1588	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	ALDH3A1_uc010vzd.1_Missense_Mutation_p.E420K|ALDH3A1_uc002gwj.2_Missense_Mutation_p.E420K|ALDH3A1_uc010cqv.2_Missense_Mutation_p.E419K|ALDH3A1_uc002gwk.2_Missense_Mutation_p.E537K|ALDH3A1_uc002gwl.1_Missense_Mutation_p.E347K	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	420					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	GAGAAAGTCTCGAAGCTCTTC	0.612													T	19641725	T	T	19641725	3	4	154	1	0	0	0	0	1	0	0	0	497	893	31	2	111	2	ALDH3A1	17	19641725	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	18946677	19641725	61553485	45	10868											
GAS2L2	246176	broad.mit.edu	37	chr17	34072169	34072169	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaggcctgtggtctctccGgggccgaatcctgggtctca	13	14	3	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr17:34072169G>A	uc002hjv.1	-	6	2375	c.2347C>T	c.(2347-2349)CGG>TGG	p.R783W		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	783					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGGTCTCTCCGGGGCCGAATC	0.612													A	34072169	A	A	34072169	3	1	154	1	0	0	0	0	1	0	0	0	6247	1115	39	2	299	2	GAS2L2	17	34072169	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	14430444	34072169	47123041	46	10869											
USH1G	124590	broad.mit.edu	37	chr17	72915620	72915620	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctcacggcccccaagatcttCtttcggggccccagtgggac	11	16	3	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr17:72915620C>T	uc002jme.1	-	2	1494	c.1311G>A	c.(1309-1311)AAG>AAA	p.K437K	USH1G_uc010wro.1_Silent_p.K334K	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	437	SAM.				equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					CCAAGATCTTCTTTCGGGGCC	0.682													T	72915620	T	T	72915620	2	4	154	1	0	0	0	0	0	0	0	1	17032	912	32	3		3	USH1G	17	72915620	Silent	SNP	C	TCGA-19-2619-01A-01D-1495-08	38843451	72915620	8279590	47	10870											
INO80C	125476	broad.mit.edu	37	chr18	33060423	33060423	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttcgatgcttaccacaaaGttgggatccttaaatggcaa	8	10	0	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr18:33060423G>A	uc002kyy.3	-	2	378	c.261C>T	c.(259-261)AAC>AAT	p.N87N	INO80C_uc002kyw.1_Silent_p.N87N|INO80C_uc002kyx.3_Silent_p.N32N|INO80C_uc010dmt.2_Silent_p.N123N	NM_194281	NP_919257	Q6PI98	IN80C_HUMAN	Ies6-similar protein isoform 2	87					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|MLL1 complex					0						TTACCACAAAGTTGGGATCCT	0.483													A	33060423	A	A	33060423	2	1	154	1	0	0	0	0	0	0	0	1	7748	1020	36	3		3	INO80C	18	33060423	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08		33060423	45016825	48	10871											
SERPINB4	6318	broad.mit.edu	37	chr18	61310407	61310407	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgactcacatgatatgttgcAgctttttctgtggtgttctc	9	8	3	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr18:61310407A>T	uc002ljf.2	-	3	296	c.210T>A	c.(208-210)GCT>GCA	p.A70A	SERPINB4_uc002lje.2_Silent_p.A70A|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	70					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						GATATGTTGCAGCTTTTTCTG	0.403													T	61310407	T	T	61310407	2	4	154	1	0	0	0	0	0	0	0	1	14103	175	7	5		5	SERPINB4	18	61310407	Silent	SNP	A	TCGA-19-2619-01A-01D-1495-08	28249984	61310407	16766841	49	10872											
CNDP1	84735	broad.mit.edu	37	chr18	72223637	72223637	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgttctcctcaccctcccCgcccccggcgctgttagaga	8	19	2	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr18:72223637C>T	uc002llq.2	+	2	300	c.89C>T	c.(88-90)CCG>CTG	p.P30L		NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	30					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		TCACCCTCCCCGCCCCCGGCG	0.537													T	72223637	T	T	72223637	3	4	154	1	0	0	0	0	1	0	0	0	3593	652	23	2	95	2	CNDP1	18	72223637	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	10913230	72223637	5853611	50	10873											
SAFB2	9667	broad.mit.edu	37	chr19	5587916	5587916	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccggctagccgcgcctgcGtccatggcaccctgccaggc	12	19	0	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr19:5587916G>A	uc002mcd.2	-	19	2813	c.2601C>T	c.(2599-2601)GAC>GAT	p.D867D		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	867	Interacts with SAFB1.|Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CCGCGCCTGCGTCCATGGCAC	0.672													A	5587916	A	A	5587916	2	1	154	1	0	0	0	0	0	0	0	1	13807	1136	40	1		1	SAFB2	19	5587916	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08		5587916	53541067	51	10874											
FBN3	84467	broad.mit.edu	37	chr19	8190851	8190851	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaagacccagcagtgttgaCgcaacgcccgttgggacaga	13	11	0	3			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr19:8190851C>T	uc002mjf.2	-	21	2677	c.2656G>A	c.(2656-2658)GTC>ATC	p.V886I		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	886	EGF-like 11; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GCAGTGTTGACGCAACGCCCG	0.637													T	8190851	T	T	8190851	3	4	154	1	0	0	0	0	1	0	0	0	5704	536	19	1	5945	1	FBN3	19	8190851	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	2602935	8190851	50938132	52	10875											
KIAA0892	23383	broad.mit.edu	37	chr19	19459728	19459728	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgctggagaggatcaacccgGaccacagcttccctgtcagg	12	13	2	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr19:19459728G>A	uc002nmk.3	+	14	1378	c.1339G>A	c.(1339-1341)GAC>AAC	p.D447N	KIAA0892_uc002nml.3_Missense_Mutation_p.D52N|KIAA0892_uc010ecd.2_Missense_Mutation_p.D52N|KIAA0892_uc010ece.2_Missense_Mutation_p.D23N	NM_015329	NP_056144	Q9Y6X3	SCC4_HUMAN	hypothetical protein LOC23383 precursor	447					cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding				0						GATCAACCCGGACCACAGCTT	0.617													A	19459728	A	A	19459728	3	1	154	1	0	0	0	0	1	0	0	0	8196	1174	41	3	1393	3	KIAA0892	19	19459728	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	11268877	19459728	39669255	53	10876											
MYH14	79784	broad.mit.edu	37	chr19	50792885	50792885	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaggctggtgaagagaggCggaggcagctggccaagcag	19	7	0	3			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr19:50792885C>T	uc002prr.1	+	33	4869	c.4822C>T	c.(4822-4824)CGG>TGG	p.R1608W	MYH14_uc010enu.1_Missense_Mutation_p.R1649W|MYH14_uc002prq.1_Missense_Mutation_p.R1616W|MYH14_uc010ycb.1_5'UTR|MYH14_uc002prs.1_5'UTR	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1608	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		TGAAGAGAGGCGGAGGCAGCT	0.612													T	50792885	T	T	50792885	3	4	154	1	0	0	0	0	1	0	0	0	10033	759	27	1	5079	1	MYH14	19	50792885	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	31333157	50792885	8336098	54	10877											
RASSF2	9770	broad.mit.edu	37	chr20	4776462	4776462	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgtctctcctcactcaccCctgagcccccaggttacagc	6	21	3	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr20:4776462C>T	uc002wld.2	-	4	340	c.286G>A	c.(286-288)GGA>AGA	p.G96R	RASSF2_uc002wlc.2_5'Flank|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.G96R	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	96					cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						CTCACTCACCCCTGAGCCCCC	0.597													T	4776462	T	T	4776462	3	4	154	1	0	0	0	0	1	0	0	0	13086	637	22	3	726	3	RASSF2	20	4776462	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08		4776462	58249058	55	10878											
TXNRD2	10587	broad.mit.edu	37	chr22	19865620	19865620	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcgggacttacttgatccCcagagcaaatccttgagtaa	8	12	0	3			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr22:19865620C>T	uc011ahc.1	-	16	1471	c.1438G>A	c.(1438-1440)GGG>AGG	p.G480R	TXNRD2_uc002zql.1_Missense_Mutation_p.G234R|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Missense_Mutation_p.G479R|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_Missense_Mutation_p.G130R	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	480					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					TACTTGATCCCCAGAGCAAAT	0.597													T	19865620	T	T	19865620	3	4	154	1	0	0	0	0	1	0	0	0	16805	623	22	3	144	3	TXNRD2	22	19865620	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08		19865620	31438946	56	10879											
SMTN	6525	broad.mit.edu	37	chr22	31492853	31492853	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggctctgctgtcagcactGttaccaagactgagcggctc	11	12	2	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chr22:31492853G>A	uc003ajl.1	+	14	2214	c.1996G>A	c.(1996-1998)GTT>ATT	p.V666I	SMTN_uc003ajk.1_Missense_Mutation_p.V666I|SMTN_uc003ajm.1_Missense_Mutation_p.V666I|SMTN_uc011ale.1_Missense_Mutation_p.V751I|SMTN_uc011alf.1_Missense_Mutation_p.V722I|SMTN_uc003ajn.1_Missense_Mutation_p.V689I|SMTN_uc011alg.1_Missense_Mutation_p.V122I|SMTN_uc003ajo.1_Intron|SMTN_uc011alh.1_RNA|SMTN_uc010gwe.1_Intron	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	666					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						TGTCAGCACTGTTACCAAGAC	0.682													A	31492853	A	A	31492853	3	1	154	1	0	0	0	0	1	0	0	0	14814	1377	48	3	2046	3	SMTN	22	31492853	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	11627233	31492853	19811713	57	10880											
NHS	4810	broad.mit.edu	37	chrX	17745612	17745612	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgaggtcgaatcctccacCgtcccttgcaattacaccaa	6	15	0	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chrX:17745612C>T	uc004cxx.2	+	6	3661	c.3323C>T	c.(3322-3324)CCG>CTG	p.P1108L	NHS_uc011mix.1_Missense_Mutation_p.P1129L|NHS_uc004cxy.2_Missense_Mutation_p.P952L|NHS_uc004cxz.2_Missense_Mutation_p.P931L|NHS_uc004cya.2_Missense_Mutation_p.P831L	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1108						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					AATCCTCCACCGTCCCTTGCA	0.408													T	17745612	T	T	17745612	3	4	154	1	0	0	0	0	1	0	0	0	10411	652	23	2	3450	2	NHS	23	17745612	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08		17745612	137524948	58	10881											
TIMM17B	10245	broad.mit.edu	37	chrX	48751096	48751096	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggggtcctccaggaatggGggcgctggagaagggagact	19	8	0	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chrX:48751096G>A	uc004dlc.1	-	7	584	c.435C>T	c.(433-435)CCC>CCT	p.P145P	TIMM17B_uc004dla.1_Silent_p.P195P|TIMM17B_uc004dlb.1_Silent_p.P165P	NM_005834	NP_005825	O60830	TI17B_HUMAN	translocase of inner mitochondrial membrane 17	145					protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CCAGGAATGGGGGCGCTGGAG	0.617													A	48751096	A	A	48751096	2	1	154	1	0	0	0	0	0	0	0	1	15906	1219	43	3		3	TIMM17B	23	48751096	Silent	SNP	G	TCGA-19-2619-01A-01D-1495-08	31005484	48751096	106519464	59	10882											
PCDH11X	27328	broad.mit.edu	37	chrX	91132985	91132985	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aacttctatgtcccagaaaaCcttccaaggcatggtacagt	7	11	1	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chrX:91132985C>A	uc004efk.1	+	2	2591	c.1746C>A	c.(1744-1746)AAC>AAA	p.N582K	PCDH11X_uc004efl.1_Missense_Mutation_p.N582K|PCDH11X_uc004efo.1_Missense_Mutation_p.N582K|PCDH11X_uc010nmv.1_Missense_Mutation_p.N582K|PCDH11X_uc004efm.1_Missense_Mutation_p.N582K|PCDH11X_uc004efn.1_Missense_Mutation_p.N582K|PCDH11X_uc004efh.1_Missense_Mutation_p.N582K|PCDH11X_uc004efj.1_Missense_Mutation_p.N582K	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	582	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TCCCAGAAAACCTTCCAAGGC	0.393													A	91132985	A	A	91132985	3	1	154	1	0	0	0	0	1	0	0	0	11508	506	18	5	1752	5	PCDH11X	23	91132985	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	42381889	91132985	64137575	60	10883											
DOCK11	139818	broad.mit.edu	37	chrX	117722099	117722099	+	Splice_Site	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ctgtttttttccctgctataGattgtattacttcttcatat	4	8	2	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chrX:117722099G>T	uc004eqp.2	+	17	1859	c.1796_splice	c.e17-1	p.N599_splice	DOCK11_uc004eqq.2_Splice_Site_p.N365_splice	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11						blood coagulation	cytosol	GTP binding			ovary(3)	3						CCCTGCTATAGATTGTATTAC	0.318													T	117722099	T	T	117722099	5	4	154	1	0	0	0	0	0	0	1	0	4686	956	33	5	1861	5	DOCK11	23	117722099	Splice_Site	SNP	G	TCGA-19-2619-01A-01D-1495-08	26589114	117722099	37548461	61	10884											
RNF113A	7737	broad.mit.edu	37	chrX	119004909	119004909	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccatgcttgtaatctgaaCggtcatggaggaatttgcag	11	8	2	1			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chrX:119004909C>T	uc004esb.2	-	1	883	c.668G>A	c.(667-669)CGT>CAT	p.R223H	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	223	C3H1-type.						nucleic acid binding|zinc ion binding			breast(2)	2						GTAATCTGAACGGTCATGGAG	0.522													T	119004909	T	T	119004909	3	4	154	1	0	0	0	0	1	0	0	0	13427	536	19	1	367	1	RNF113A	23	119004909	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	1282810	119004909	36265651	62	10885											
ARHGAP36	158763	broad.mit.edu	37	chrX	130220576	130220576	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aggatgcactactttctgatCcagtggaaacctctgctgaa	9	10	2	2			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chrX:130220576C>T	uc004evz.2	+	11	1768	c.1423C>T	c.(1423-1425)CCA>TCA	p.P475S	ARHGAP36_uc004ewa.2_Missense_Mutation_p.P463S|ARHGAP36_uc004ewb.2_Missense_Mutation_p.P444S|ARHGAP36_uc004ewc.2_Missense_Mutation_p.P339S	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	475					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						ACTTTCTGATCCAGTGGAAAC	0.478													T	130220576	T	T	130220576	3	4	154	1	0	0	0	0	1	0	0	0	883	855	30	3	1461	3	ARHGAP36	23	130220576	Missense_Mutation	SNP	C	TCGA-19-2619-01A-01D-1495-08	11215667	130220576	25049984	63	10886											
CTAG2	30848	broad.mit.edu	37	chrX	153881755	153881755	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggccatcagcatcgcccGtcgaaccccctgtgccctgg	11	18	1	0			TCGA-19-2619-01A-01D-1495-08	TCGA-19-2619-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b765a4c7-4fe8-444c-95bd-6a4d03af1432	f4f9cd59-cdbd-4ee2-908b-31bb8aa6750a	g.chrX:153881755G>A	uc004fmi.1	-	1	88	c.35C>T	c.(34-36)ACG>ATG	p.T12M	CTAG2_uc004fmh.1_Missense_Mutation_p.T12M	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	12	Gly-rich.					centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGCATCGCCCGTCGAACCCCC	0.706													A	153881755	A	A	153881755	3	1	154	1	0	0	0	0	1	0	0	0	3991	1145	40	1	744	1	CTAG2	23	153881755	Missense_Mutation	SNP	G	TCGA-19-2619-01A-01D-1495-08	23661179	153881755	1388805	64	10887											
PTCHD2	57540	broad.mit.edu	37	chr1	11562051	11562051	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctcctactcctactgctcGccccccagctcgctcatgac	7	20	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr1:11562051G>A	uc001ash.3	+	2	1140	c.1002G>A	c.(1000-1002)TCG>TCA	p.S334S	PTCHD2_uc001asi.1_Silent_p.S334S	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	334	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCTACTGCTCGCCCCCCAGCT	0.627													A	11562051	A	A	11562051	2	1	155	1	0	0	0	0	0	0	0	1	12733	1074	38	1		1	PTCHD2	1	11562051	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08		11562051	237688570	1	10888											
LRRC8B	23507	broad.mit.edu	37	chr1	90048973	90048973	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggagcagaaggacatcatttAtagagtatatctgaaacaga	10	5	2	4			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr1:90048973A>G	uc001dni.2	+	7	1271	c.764A>G	c.(763-765)TAT>TGT	p.Y255C	LRRC8B_uc001dnh.2_Missense_Mutation_p.Y255C|LRRC8B_uc001dnj.2_Missense_Mutation_p.Y255C	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	255						integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GACATCATTTATAGAGTATAT	0.383													G	90048973	G	G	90048973	3	3	155	1	0	0	0	0	1	0	0	0	9022	449	16	4	766	4	LRRC8B	1	90048973	Missense_Mutation	SNP	A	TCGA-19-2620-01A-01D-1495-08	78486922	90048973	159201648	2	10889											
GPR61	83873	broad.mit.edu	37	chr1	110086040	110086040	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcagcctggccatcctctcGgtgtcagccatcaatgtgga	11	13	4	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr1:110086040G>A	uc001dxy.2	+	2	1079	c.396G>A	c.(394-396)TCG>TCA	p.S132S		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	132	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCATCCTCTCGGTGTCAGCCA	0.607													A	110086040	A	A	110086040	2	1	155	1	0	0	0	0	0	0	0	1	6702	1103	39	2		2	GPR61	1	110086040	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	20037067	110086040	139164581	3	10890											
TTF2	8458	broad.mit.edu	37	chr1	117618058	117618058	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggggacccctcaacaaggaGtacacgaactgggaggctaa	14	10	1	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr1:117618058G>A	uc001egy.2	+	5	872	c.852G>A	c.(850-852)GAG>GAA	p.E284E	TTF2_uc001egx.1_Silent_p.E284E	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	284					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TCAACAAGGAGTACACGAACT	0.522													A	117618058	A	A	117618058	2	1	155	1	0	0	0	0	0	0	0	1	16716	1020	36	3		3	TTF2	1	117618058	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	7532018	117618058	131632563	4	10891											
FLG	2312	broad.mit.edu	37	chr1	152283519	152283519	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagacaacctctcggagtcGtctgagtgtctctcactgtc	9	14	4	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr1:152283519G>A	uc001ezu.1	-	3	3879	c.3843C>T	c.(3841-3843)GAC>GAT	p.D1281D	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1281	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTCGGAGTCGTCTGAGTGTC	0.383									Ichthyosis				A	152283519	A	A	152283519	2	1	155	1	0	0	0	0	0	0	0	1	5922	1136	40	1		1	FLG	1	152283519	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	34665461	152283519	96967102	5	10892											
HMCN1	83872	broad.mit.edu	37	chr1	186050515	186050515	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataaatttctatctaatggaCgaattctgcaggtaaaagta	7	5	3	0	rs142475663		TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr1:186050515C>T	uc001grq.1	+	56	9005	c.8776C>T	c.(8776-8778)CGA>TGA	p.R2926*		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2926	Ig-like C2-type 27.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATCTAATGGACGAATTCTGCA	0.338													T	186050515	T	T	186050515	4	4	155	1	0	0	0	0	0	1	0	0	7220	528	19	1	8998	1	HMCN1	1	186050515	Nonsense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	33766996	186050515	63200106	6	10893											
HMCN1	83872	broad.mit.edu	37	chr1	186083185	186083185	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caactgtattggaatgcatcGctgaaggtgtgccaactcca	10	10	0	1	rs138190200	byFrequency	TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr1:186083185G>A	uc001grq.1	+	73	11435	c.11206G>A	c.(11206-11208)GCT>ACT	p.A3736T		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3736	Ig-like C2-type 36.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GGAATGCATCGCTGAAGGTGT	0.408													A	186083185	A	A	186083185	3	1	155	1	0	0	0	0	1	0	0	0	7220	1087	38	1	11496	1	HMCN1	1	186083185	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	32670	186083185	63167436	7	10894											
NUAK2	81788	broad.mit.edu	37	chr1	205280831	205280831	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagctttaagtgcccactgtAccttcatggatggcaatgat	9	10	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr1:205280831A>G	uc001hce.2	-	2	479	c.352_splice	c.e2+1	p.V118_splice	NUAK2_uc009xbj.1_5'Flank	NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2						actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TGCCCACTGTACCTTCATGGA	0.413													G	205280831	G	G	205280831	5	3	155	1	0	0	0	0	0	0	1	0	10713	405	14	4	1556	4	NUAK2	1	205280831	Splice_Site	SNP	A	TCGA-19-2620-01A-01D-1495-08	19197646	205280831	43969790	8	10895											
TRAF3IP3	80342	broad.mit.edu	37	chr1	209954760	209954760	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctgcgtaagctgcagcActgtcgagaagagctgaacc	12	12	0	3			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr1:209954760A>T	uc001hho.2	+	16	1810	c.1520A>T	c.(1519-1521)CAC>CTC	p.H507L	TRAF3IP3_uc001hhn.2_Missense_Mutation_p.H487L|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.H507L	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	507	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		AAGCTGCAGCACTGTCGAGAA	0.512													T	209954760	T	T	209954760	3	4	155	1	0	0	0	0	1	0	0	0	16439	159	6	5	1574	5	TRAF3IP3	1	209954760	Missense_Mutation	SNP	A	TCGA-19-2620-01A-01D-1495-08	4673929	209954760	39295861	9	10896											
LPIN1	23175	broad.mit.edu	37	chr2	11943091	11943091	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctgccaagccatcaaacGcaggccacctccctcttctg	7	18	3	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr2:11943091G>A	uc010yjn.1	+	15	2111	c.1837G>A	c.(1837-1839)GCA>ACA	p.A613T	LPIN1_uc010yjm.1_Missense_Mutation_p.A698T|LPIN1_uc002rbt.2_Missense_Mutation_p.A613T|LPIN1_uc010yjo.1_Missense_Mutation_p.A114T	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	613					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		GCCATCAAACGCAGGCCACCT	0.532													A	11943091	A	A	11943091	3	1	155	1	0	0	0	0	1	0	0	0	8918	1087	38	1	1887	1	LPIN1	2	11943091	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08		11943091	231256282	10	10897											
IL1RL1	9173	broad.mit.edu	37	chr2	102959595	102959595	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggaacaaaaattacagactTtggtgaaccaagaattcaac	7	7	1	3			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr2:102959595T>C	uc002tbu.1	+	7	1053	c.782T>C	c.(781-783)TTT>TCT	p.F261S	IL1RL1_uc010ywa.1_Missense_Mutation_p.F144S|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Missense_Mutation_p.F261S	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	261	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						ATTACAGACTTTGGTGAACCA	0.423													C	102959595	C	C	102959595	3	2	155	1	0	0	0	0	1	0	0	0	7663	1841	64	4	804	4	IL1RL1	2	102959595	Missense_Mutation	SNP	T	TCGA-19-2620-01A-01D-1495-08	91016504	102959595	140239778	11	10898											
LRP2	4036	broad.mit.edu	37	chr2	170066149	170066149	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccacatgcagtgcgtttcGtcctggaagttaagaaaaga	10	8	0	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr2:170066149G>A	uc002ues.2	-	38	6496	c.6283C>T	c.(6283-6285)CGA>TGA	p.R2095*		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2095	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGTGCGTTTCGTCCTGGAAGT	0.418													A	170066149	A	A	170066149	4	1	155	1	0	0	0	0	0	1	0	0	8956	1153	40	1	7852	1	LRP2	2	170066149	Nonsense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	67106554	170066149	73133224	12	10899											
DNAH7	56171	broad.mit.edu	37	chr2	196765215	196765215	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cattgctactgtccgaaagaGagcctatgggtaggtagaaa	12	7	0	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr2:196765215G>C	uc002utj.3	-	28	4440	c.4339C>G	c.(4339-4341)CTC>GTC	p.L1447V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1447	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GTCCGAAAGAGAGCCTATGGG	0.303													C	196765215	C	C	196765215	3	2	155	1	0	0	0	0	1	0	0	0	4606	942	33	5	7887	5	DNAH7	2	196765215	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	26699066	196765215	46434158	13	10900											
AOX1	316	broad.mit.edu	37	chr2	201478598	201478598	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtctcccttttgggctcggCgccaggtgggaaagtggagt	16	9	1	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr2:201478598C>T	uc002uvx.2	+	15	1621	c.1520C>T	c.(1519-1521)GCG>GTG	p.A507V	AOX1_uc010zhf.1_Missense_Mutation_p.A63V|AOX1_uc010fsu.2_5'UTR	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	507					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TTGGGCTCGGCGCCAGGTGGG	0.473													T	201478598	T	T	201478598	3	4	155	1	0	0	0	0	1	0	0	0	729	768	27	1	1578	1	AOX1	2	201478598	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	4713383	201478598	41720775	14	10901											
FAM126B	285172	broad.mit.edu	37	chr2	201881771	201881771	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccattactctgtctgtctcgGctaactgtaagccgtaaata	7	11	3	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr2:201881771G>A	uc002uws.3	-	5	464	c.276C>T	c.(274-276)AGC>AGT	p.S92S	FAM126B_uc002uwu.2_Silent_p.S10S|FAM126B_uc002uwv.2_Silent_p.S92S|FAM126B_uc002uww.1_Silent_p.S92S	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	92						intracellular				ovary(1)	1						GTCTGTCTCGGCTAACTGTAA	0.388													A	201881771	A	A	201881771	2	1	155	1	0	0	0	0	0	0	0	1	5430	1194	42	3		3	FAM126B	2	201881771	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	403173	201881771	41317602	15	10902											
TRPM8	79054	broad.mit.edu	37	chr2	234835206	234835206	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tcctttcgggcagccaggctCagcatgaggaacagaaggaa	13	10	1	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr2:234835206C>A	uc002vvh.2	+	2	64	c.24C>A	c.(22-24)CTC>CTA	p.L8L	TRPM8_uc010fyj.2_5'UTR	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	8	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CAGCCAGGCTCAGCATGAGGA	0.522													A	234835206	A	A	234835206	2	1	155	1	0	0	0	0	0	0	0	1	16589	813	29	5		5	TRPM8	2	234835206	Silent	SNP	C	TCGA-19-2620-01A-01D-1495-08	32953435	234835206	8364167	16	10903											
OR5H2	79310	broad.mit.edu	37	chr3	98001924	98001924	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cacaacttcacatccccatgTacttttttcttgggagttta	5	11	2	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr3:98001924T>A	uc003dsj.1	+	1	193	c.193T>A	c.(193-195)TAC>AAC	p.Y65N		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						CATCCCCATGTACTTTTTTCT	0.408													A	98001924	A	A	98001924	3	1	155	1	0	0	0	0	1	0	0	0	11162	1638	57	5	195	5	OR5H2	3	98001924	Missense_Mutation	SNP	T	TCGA-19-2620-01A-01D-1495-08		98001924	100020506	17	10904											
OR5H2	79310	broad.mit.edu	37	chr3	98002428	98002428	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcttttcacaatcctaaaaAagaagtctgttagaggcgta	7	8	3	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr3:98002428A>C	uc003dsj.1	+	1	697	c.697A>C	c.(697-699)AAG>CAG	p.K233Q		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						AATCCTAAAAAAGAAGTCTGT	0.363													C	98002428	C	C	98002428	3	2	155	1	0	0	0	0	1	0	0	0	11162	15	1	5	699	5	OR5H2	3	98002428	Missense_Mutation	SNP	A	TCGA-19-2620-01A-01D-1495-08	504	98002428	100020002	18	10905											
SLCO2A1	6578	broad.mit.edu	37	chr3	133692615	133692615	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgccaatcagacgtggacGgtgcacccggctgccaaagt	13	12	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr3:133692615G>A	uc003eqa.3	-	3	563	c.289C>T	c.(289-291)CGT>TGT	p.R97C	SLCO2A1_uc003eqb.3_Missense_Mutation_p.R97C|SLCO2A1_uc011blv.1_Missense_Mutation_p.R97C|SLCO2A1_uc010htw.1_5'UTR	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	97	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						AGACGTGGACGGTGCACCCGG	0.572													A	133692615	A	A	133692615	3	1	155	1	0	0	0	0	1	0	0	0	14726	1116	39	2	1690	2	SLCO2A1	3	133692615	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	35690187	133692615	64329815	19	10906											
SR140	23350	broad.mit.edu	37	chr3	142735741	142735741	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taagccatcttcaagatttgCagatcaaaaaaatcctccaa	4	10	3	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr3:142735741C>T	uc003evh.1	+	6	593	c.494C>T	c.(493-495)GCA>GTA	p.A165V	SR140_uc003evi.1_5'UTR|SR140_uc011bnj.1_Missense_Mutation_p.A165V|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.A165V	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	165					RNA processing	nucleus	nucleotide binding|RNA binding				0						TCAAGATTTGCAGATCAAAAA	0.303													T	142735741	T	T	142735741	3	4	155	1	0	0	0	0	1	0	0	0	15130	710	25	3	516	3	SR140	3	142735741	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	9043126	142735741	55286689	20	10907											
BCHE	590	broad.mit.edu	37	chr3	165548715	165548715	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctctgacttttccattctttGttgcaattatgatgtcatct	5	9	4	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr3:165548715G>T	uc003fem.3	-	2	267	c.107C>A	c.(106-108)ACA>AAA	p.T36K	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	36					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	TCCATTCTTTGTTGCAATTAT	0.408													T	165548715	T	T	165548715	3	4	155	1	0	0	0	0	1	0	0	0	1358	1377	48	5	1713	5	BCHE	3	165548715	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	22812974	165548715	32473715	21	10908											
GHSR	2693	broad.mit.edu	37	chr3	172165593	172165593	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagcagtccagagcgcaccGcaaactcggtggggcggcac	15	13	0	2	rs121917883		TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr3:172165593G>A	uc003fib.1	-	1	611	c.611C>T	c.(610-612)GCG>GTG	p.A204V	GHSR_uc011bpv.1_Missense_Mutation_p.A204V	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	204	Extracellular (Potential).		A -> E (in ISSA; affects cell-surface expression; impairs constitutive activity but not the ability to respond to ghrelin).		actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			AGAGCGCACCGCAAACTCGGT	0.622													A	172165593	A	A	172165593	3	1	155	1	0	0	0	0	1	0	0	0	6375	1087	38	1	571	1	GHSR	3	172165593	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	6616878	172165593	25856837	22	10909											
CCDC158	339965	broad.mit.edu	37	chr4	77288530	77288530	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcatagctccagcagttcGtccatgctggcccaccagct	9	15	0	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr4:77288530G>A	uc003hkb.3	-	11	1900	c.1747C>T	c.(1747-1749)CGA>TGA	p.R583*		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	583	Potential.									skin(3)|ovary(2)|pancreas(1)	6						CCAGCAGTTCGTCCATGCTGG	0.453													A	77288530	A	A	77288530	4	1	155	1	0	0	0	0	0	1	0	0	2790	1153	40	1	1650	1	CCDC158	4	77288530	Nonsense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08		77288530	113865746	23	10910											
SEC31A	22872	broad.mit.edu	37	chr4	83799939	83799939	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtatgcttgtcattctgggCaatcacaacttccttgtctc	7	11	4	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr4:83799939C>T	uc003hnf.2	-	4	510	c.346G>A	c.(346-348)GCC>ACC	p.A116T	SEC31A_uc011ccl.1_Missense_Mutation_p.A116T|SEC31A_uc003hnl.2_Missense_Mutation_p.A116T|SEC31A_uc003hng.2_Missense_Mutation_p.A116T|SEC31A_uc003hnh.2_Missense_Mutation_p.A116T|SEC31A_uc003hni.2_Missense_Mutation_p.A116T|SEC31A_uc003hnj.2_Missense_Mutation_p.A116T|SEC31A_uc011ccm.1_Missense_Mutation_p.A111T|SEC31A_uc011ccn.1_Missense_Mutation_p.A116T|SEC31A_uc003hnk.2_Missense_Mutation_p.A116T|SEC31A_uc003hnm.2_Missense_Mutation_p.A116T|SEC31A_uc003hnn.1_Missense_Mutation_p.A116T|SEC31A_uc003hno.2_Missense_Mutation_p.A116T	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	116					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				TCATTCTGGGCAATCACAACT	0.398													T	83799939	T	T	83799939	3	4	155	1	0	0	0	0	1	0	0	0	13998	710	25	3	3412	3	SEC31A	4	83799939	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	6511409	83799939	107354337	24	10911											
PCDH18	54510	broad.mit.edu	37	chr4	138451923	138451923	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagagagactgggtgtcccCctgtcctcagcgattacagt	12	11	1	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr4:138451923C>T	uc003ihe.3	-	1	1707	c.1320G>A	c.(1318-1320)AGG>AGA	p.R440R	PCDH18_uc003ihf.3_Silent_p.R433R|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Silent_p.R220R|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	440	Cadherin 4.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TGGGTGTCCCCCTGTCCTCAG	0.373													T	138451923	T	T	138451923	2	4	155	1	0	0	0	0	0	0	0	1	11513	622	22	3		3	PCDH18	4	138451923	Silent	SNP	C	TCGA-19-2620-01A-01D-1495-08	54651984	138451923	52702353	25	10912											
MYO10	4651	broad.mit.edu	37	chr5	16668507	16668507	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagtggtcttccctctccaCgcttgtagacggagacggcg	12	14	2	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr5:16668507C>T	uc003jft.3	-	40	6422	c.5954G>A	c.(5953-5955)CGT>CAT	p.R1985H	MYO10_uc011cnb.1_Missense_Mutation_p.R614H|MYO10_uc011cnc.1_Missense_Mutation_p.R864H|MYO10_uc011cnd.1_Missense_Mutation_p.R1342H|MYO10_uc011cne.1_Missense_Mutation_p.R1342H|MYO10_uc010itx.2_Missense_Mutation_p.R1607H	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1985	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TCCCTCTCCACGCTTGTAGAC	0.547													T	16668507	T	T	16668507	3	4	155	1	0	0	0	0	1	0	0	0	10062	536	19	1	230	1	MYO10	5	16668507	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08		16668507	164246753	26	10913											
CDH9	1007	broad.mit.edu	37	chr5	26885965	26885965	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttccgagtcatgattcctGctgtattatctgggggagaa	11	8	2	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr5:26885965G>A	uc003jgs.1	-	11	1809	c.1640C>T	c.(1639-1641)GCA>GTA	p.A547V	CDH9_uc011cnv.1_Missense_Mutation_p.A140V	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	547	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CATGATTCCTGCTGTATTATC	0.318													A	26885965	A	A	26885965	3	1	155	1	0	0	0	0	1	0	0	0	3117	1319	46	3	737	3	CDH9	5	26885965	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	10217458	26885965	154029295	27	10914											
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139889605	139889605	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taatatgccttgtttacaggGgagcccacattgatgttcgt	10	8	0	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr5:139889605G>A	uc003lfs.1	+	22	4067	c.3943G>A	c.(3943-3945)GGA>AGA	p.G1315R	ANKHD1_uc003lfq.1_Missense_Mutation_p.G1334R|ANKHD1_uc003lfr.2_Missense_Mutation_p.G1315R|ANKHD1_uc003lft.1_Missense_Mutation_p.G526R|ANKHD1_uc003lfu.1_Missense_Mutation_p.G795R|ANKHD1_uc003lfv.1_Missense_Mutation_p.G392R|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.G54R|ANKHD1_uc003lfw.2_5'UTR	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1315						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTTACAGGGGAGCCCACAT	0.393													A	139889605	A	A	139889605	3	1	155	1	0	0	0	0	1	0	0	0	629	1246	43	3	4029	3	ANKHD1-EIF4EBP3	5	139889605	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	113003640	139889605	41025655	28	10915											
PCDHA4	56144	broad.mit.edu	37	chr5	140188686	140188686	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcacaacgcgtgccctggaCgaaacggacgctccgcgcca	12	16	0	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr5:140188686C>T	uc003lhi.2	+	1	2015	c.1914C>T	c.(1912-1914)GAC>GAT	p.D638D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.D638D|PCDHA4_uc011daa.1_Silent_p.D638D	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	638	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCCCTGGACGAAACGGACG	0.677													T	140188686	T	T	140188686	2	4	155	1	0	0	0	0	0	0	0	1	11526	535	19	1		1	PCDHA4	5	140188686	Silent	SNP	C	TCGA-19-2620-01A-01D-1495-08	299081	140188686	40726574	29	10916											
PCDHGB3	56102	broad.mit.edu	37	chr5	140751537	140751537	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttcgaccacgagcagctgCgtgccttcgagctcactctg	10	16	2	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr5:140751537C>T	uc003ljw.1	+	1	1576	c.1576C>T	c.(1576-1578)CGT>TGT	p.R526C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.R526C|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	526	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGCAGCTGCGTGCCTTCGA	0.692													T	140751537	T	T	140751537	3	4	155	1	0	0	0	0	1	0	0	0	11564	768	27	1	1578	1	PCDHGB3	5	140751537	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	562851	140751537	40163723	30	10917											
CAMK2A	815	broad.mit.edu	37	chr5	149602771	149602771	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgcacgggcttgctgttcCgggaccacactggaggaggg	17	10	0	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr5:149602771C>T	uc003lru.2	-	17	1429	c.1214G>A	c.(1213-1215)CGG>CAG	p.R405Q	CAMK2A_uc003lrs.2_Missense_Mutation_p.R116Q|CAMK2A_uc003lrt.2_Missense_Mutation_p.R416Q	NM_171825	NP_741960	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II	405					interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTGCTGTTCCGGGACCACAC	0.612													T	149602771	T	T	149602771	3	4	155	1	0	0	0	0	1	0	0	0	2599	652	23	2	230	2	CAMK2A	5	149602771	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	8851234	149602771	31312489	31	10918											
LARP1	23367	broad.mit.edu	37	chr5	154188110	154188110	+	Silent	SNP	G	A	A													cgagatcacttcaacaaaaaGatgtatgaggagttcaagca							TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr5:154188110G>A	uc003lvp.2	+	16	3219	c.2790G>A	c.(2788-2790)AAG>AAA	p.K930K	LARP1_uc003lvo.2_Silent_p.K853K	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	930							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCAACAAAAAGATGTATGAGG	0.532													A	154188110	A	A	154188110	2	1	155	1	0	0	0	0	0	0	0	1	8628	933	33	3		3	LARP1	5	154188110	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	4585339	154188110	26727150	32	10919	14	2									
LARP1	23367	broad.mit.edu	37	chr5	154188112	154188112	+	Missense_Mutation	SNP	T	A	A													agatcacttcaacaaaaagaTgtatgaggagttcaagcagc							TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr5:154188112T>A	uc003lvp.2	+	16	3221	c.2792T>A	c.(2791-2793)ATG>AAG	p.M931K	LARP1_uc003lvo.2_Missense_Mutation_p.M854K	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	931							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AACAAAAAGATGTATGAGGAG	0.532													A	154188112	A	A	154188112	3	1	155	1	0	0	0	0	1	0	0	0	8628	1464	51	5	2623	5	LARP1	5	154188112	Missense_Mutation	SNP	T	TCGA-19-2620-01A-01D-1495-08	2	154188112	26727148	33	10920	14	2									
GABRA6	2559	broad.mit.edu	37	chr5	161116737	161116737	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cttcaagccttctccagtatGatctgattggacaaacagta	7	10	3	2	rs145469537		TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr5:161116737G>T	uc003lyu.2	+	6	963	c.625G>T	c.(625-627)GAT>TAT	p.D209Y	GABRA6_uc003lyv.2_5'UTR	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	209	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity	p.D209N(1)		ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCTCCAGTATGATCTGATTGG	0.378										TCGA Ovarian(5;0.080)			T	161116737	T	T	161116737	3	4	155	1	0	0	0	0	1	0	0	0	6165	1290	45	5	647	5	GABRA6	5	161116737	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	6928625	161116737	19798523	34	10921											
ENPP5	59084	broad.mit.edu	37	chr6	46135819	46135819	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacattagtaacttgcttcaCgtgaacaccatatttcataa	4	9	2	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr6:46135819C>T	uc003oxz.1	-	2	389	c.181G>A	c.(181-183)GTG>ATG	p.V61M	ENPP5_uc003oya.1_Missense_Mutation_p.V61M|ENPP5_uc011dvz.1_Intron|ENPP5_uc010jzc.1_Missense_Mutation_p.V61M	NM_021572	NP_067547	Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	61						extracellular region|integral to membrane	hydrolase activity				0						ACTTGCTTCACGTGAACACCA	0.348													T	46135819	T	T	46135819	3	4	155	1	0	0	0	0	1	0	0	0	5133	536	19	1	1264	1	ENPP5	6	46135819	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08		46135819	124979248	35	10922											
LGSN	51557	broad.mit.edu	37	chr6	63991054	63991054	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtggctcttatgttattcatTtcattgtcctttggatttgg	9	6	3	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr6:63991054T>A	uc003peh.2	-	4	436	c.402A>T	c.(400-402)GAA>GAT	p.E134D	LGSN_uc003pei.2_Missense_Mutation_p.E134D	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	134					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	TGTTATTCATTTCATTGTCCT	0.393													A	63991054	A	A	63991054	3	1	155	1	0	0	0	0	1	0	0	0	8759	1838	64	5	1131	5	LGSN	6	63991054	Missense_Mutation	SNP	T	TCGA-19-2620-01A-01D-1495-08	17855235	63991054	107124013	36	10923											
EPHA7	2045	broad.mit.edu	37	chr6	93956625	93956625	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	acgctccttttgccaacaatCcaacattagctggtgaaggc	8	12	0	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr6:93956625C>G	uc003poe.2	-	15	2852	c.2611G>C	c.(2611-2613)GAT>CAT	p.D871H	EPHA7_uc003pof.2_Missense_Mutation_p.D866H|EPHA7_uc011eac.1_Missense_Mutation_p.D867H	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	871	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGCCAACAATCCAACATTAGC	0.418													G	93956625	G	G	93956625	3	3	155	1	0	0	0	0	1	0	0	0	5172	855	30	5	397	5	EPHA7	6	93956625	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	29965571	93956625	77158442	37	10924											
MAN1A1	4121	broad.mit.edu	37	chr6	119669897	119669897	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctccagggcggcctccgggtCcccgggtgccccctcctcgc	13	21	0	0	rs139302645		TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr6:119669897C>G	uc003pym.1	-	2	776	c.334G>C	c.(334-336)GAC>CAC	p.D112H	MAN1A1_uc010kei.1_Missense_Mutation_p.D112H	NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	112	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		GCCTCCGGGTCCCCGGGTGCC	0.502													G	119669897	G	G	119669897	3	3	155	1	0	0	0	0	1	0	0	0	9210	855	30	5	1675	5	MAN1A1	6	119669897	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	25713272	119669897	51445170	38	10925											
MED23	9439	broad.mit.edu	37	chr6	131929144	131929144	+	Frame_Shift_Del	DEL	C	-	-													gtgcatttttctgaatacttCcagaaatgaattgcaggaga							TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr6:131929144delC	uc003qcs.1	-	12	1319	c.1145delG	c.(1144-1146)GGAfs	p.G382fs	MED23_uc003qcq.2_Frame_Shift_Del_p.G388fs|MED23_uc011eca.1_Intron|MED23_uc003qct.1_Frame_Shift_Del_p.G388fs|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	382					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		CTGAATACTTCCAGAAATGAA	0.378													-	131929144	-	-	131929144	7	5	155	1	0	1	0	1	0	0	0	0	9441	855	30	0	3040	0	MED23	6	131929144	Frame_Shift_Del	DEL	C	TCGA-19-2620-01A-01D-1495-08	12259247	131929144	39185923	39	10926											
ECT2L	345930	broad.mit.edu	37	chr6	139183819	139183819	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaactggcacgttctttacGgcccccactgggattgcaac	9	14	1	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr6:139183819G>A	uc003qif.1	+	9	1357	c.1254G>A	c.(1252-1254)ACG>ACA	p.T418T	ECT2L_uc011edq.1_Silent_p.T349T	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	418					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						CGTTCTTTACGGCCCCCACTG	0.463													A	139183819	A	A	139183819	2	1	155	1	0	0	0	0	0	0	0	1	4902	1103	39	2		2	ECT2L	6	139183819	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	7254675	139183819	31931248	40	10927											
MAP3K4	4216	broad.mit.edu	37	chr6	161470034	161470034	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagtctcaaagaaaaaagacAgggagcaaagaggacaagaa	11	6	1	4			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr6:161470034A>G	uc003qtn.2	+	3	872	c.730A>G	c.(730-732)AGG>GGG	p.R244G	MAP3K4_uc010kkc.1_Missense_Mutation_p.R244G|MAP3K4_uc003qto.2_Missense_Mutation_p.R244G|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	244					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GAAAAAAGACAGGGAGCAAAG	0.433													G	161470034	G	G	161470034	3	3	155	1	0	0	0	0	1	0	0	0	9252	179	7	4	740	4	MAP3K4	6	161470034	Missense_Mutation	SNP	A	TCGA-19-2620-01A-01D-1495-08	22286215	161470034	9645033	41	10928											
NPC1L1	29881	broad.mit.edu	37	chr7	44579249	44579249	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggagcaggtcgccacgtcGtcaccttgggactcattgca	12	13	2	0	rs148698796		TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr7:44579249G>A	uc003tlb.2	-	2	803	c.747C>T	c.(745-747)GAC>GAT	p.D249D	NPC1L1_uc003tlc.2_Silent_p.D249D|NPC1L1_uc011kbw.1_Silent_p.D249D|NPC1L1_uc003tld.2_Silent_p.D249D	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	249	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	TCGCCACGTCGTCACCTTGGG	0.632													A	44579249	A	A	44579249	2	1	155	1	0	0	0	0	0	0	0	1	10571	1136	40	1		1	NPC1L1	7	44579249	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08		44579249	114559414	42	10929											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	155	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	10653794	55233043	103905620	43	10930											
CACNA2D1	781	broad.mit.edu	37	chr7	81598223	81598223	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcaggtttaagaagtttcCcttgaatatatatttctaca	6	7	1	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr7:81598223C>T	uc003uhr.1	-	29	2631	c.2375G>A	c.(2374-2376)GGG>GAG	p.G792E	CACNA2D1_uc011kgy.1_Intron	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	804	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AAGAAGTTTCCCTTGAATATA	0.284													T	81598223	T	T	81598223	3	4	155	1	0	0	0	0	1	0	0	0	2548	623	22	3	944	3	CACNA2D1	7	81598223	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	26365180	81598223	77540440	44	10931											
CHMP4C	92421	broad.mit.edu	37	chr8	82644913	82644913	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggctcttctaagagccgaGccgctcccagtccccaggag	12	16	2	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr8:82644913G>A	uc003ycl.2	+	1	226	c.52G>A	c.(52-54)GCC>ACC	p.A18T		NM_152284	NP_689497	Q96CF2	CHM4C_HUMAN	chromatin modifying protein 4C	18	Intramolecular interaction with C- terminus (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			ovary(2)	2						TAAGAGCCGAGCCGCTCCCAG	0.587													A	82644913	A	A	82644913	3	1	155	1	0	0	0	0	1	0	0	0	3358	971	34	3	54	3	CHMP4C	8	82644913	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08		82644913	63719109	45	10932											
WDYHV1	55093	broad.mit.edu	37	chr8	124453566	124453566	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attccaaaatgaacctgaacGatttcatcagtatggatccc	6	10	2	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr8:124453566G>A	uc003yqn.1	+	6	654	c.529G>A	c.(529-531)GAT>AAT	p.D177N	WDYHV1_uc011lij.1_Missense_Mutation_p.D117N|WDYHV1_uc003yqo.1_RNA	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	177					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)|skin(1)	2						GAACCTGAACGATTTCATCAG	0.373													A	124453566	A	A	124453566	3	1	155	1	0	0	0	0	1	0	0	0	17340	1058	37	2	551	2	WDYHV1	8	124453566	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	41808653	124453566	21910456	46	10933											
SLC45A4	57210	broad.mit.edu	37	chr8	142228261	142228261	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagccacagcaggcgcaccGtggtctcgccctccccctcc	10	20	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr8:142228261G>A	uc003ywd.1	-	4	1633	c.1325C>T	c.(1324-1326)ACG>ATG	p.T442M	SLC45A4_uc003ywc.1_Missense_Mutation_p.T442M|SLC45A4_uc010meq.1_Missense_Mutation_p.T440M	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	493					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CAGGCGCACCGTGGTCTCGCC	0.682													A	142228261	A	A	142228261	3	1	155	1	0	0	0	0	1	0	0	0	14643	1145	40	1	1091	1	SLC45A4	8	142228261	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	17774695	142228261	4135761	47	10934											
RHPN1	114822	broad.mit.edu	37	chr8	144462083	144462083	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtctcctggactgccctgGtgcatgtcaaggccgagtac	12	13	2	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr8:144462083G>A	uc003yyb.2	+	9	1163	c.1030G>A	c.(1030-1032)GTG>ATG	p.V344M		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	344	BRO1.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			GACTGCCCTGGTGCATGTCAA	0.657													A	144462083	A	A	144462083	3	1	155	1	0	0	0	0	1	0	0	0	13350	1261	44	3	1064	3	RHPN1	8	144462083	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	2233822	144462083	1901939	48	10935											
TAF1L	138474	broad.mit.edu	37	chr9	32633610	32633610	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgtgctttagcaaaggTtggactgaatggggacctgg	15	5	0	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr9:32633610T>A	uc003zrg.1	-	1	2058	c.1968A>T	c.(1966-1968)CAA>CAT	p.Q656H	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	656					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTAGCAAAGGTTGGACTGAAT	0.502													A	32633610	A	A	32633610	3	1	155	1	0	0	0	0	1	0	0	0	15520	1722	60	5	3516	5	TAF1L	9	32633610	Missense_Mutation	SNP	T	TCGA-19-2620-01A-01D-1495-08		32633610	108579821	49	10936											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112899196	112899196	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggagaggagagagctcatcCgcagccaggccgtcaagaag	15	10	2	3			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr9:112899196C>T	uc004bei.2	+	9	2260	c.2068C>T	c.(2068-2070)CGC>TGC	p.R690C	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.R458C|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.R458C|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.R268C|AKAP2_uc011lwi.1_Missense_Mutation_p.R316C|AKAP2_uc004bem.2_Missense_Mutation_p.R316C|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.R276C|AKAP2_uc011lwj.1_Missense_Mutation_p.R227C|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.R227C	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	227	Potential.						enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AGAGCTCATCCGCAGCCAGGC	0.512													T	112899196	T	T	112899196	3	4	155	1	0	0	0	0	1	0	0	0	11410	652	23	2	1402	2	PALM2-AKAP2	9	112899196	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	80265586	112899196	28314235	50	10937											
PMPCA	23203	broad.mit.edu	37	chr9	139306464	139306464	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttaggtttggacctcctgcGtacagacggtttagtagtgg	13	7	0	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr9:139306464G>A	uc004chl.2	+	2	92	c.87G>A	c.(85-87)GCG>GCA	p.A29A	SDCCAG3_uc004chi.2_5'Flank|SDCCAG3_uc004chj.2_5'Flank|SDCCAG3_uc004chk.2_5'Flank|PMPCA_uc011mdy.1_Silent_p.A29A|PMPCA_uc010nbk.2_RNA|PMPCA_uc010nbl.2_5'UTR|PMPCA_uc011mdz.1_5'UTR	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	29					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		GACCTCCTGCGTACAGACGGT	0.493													A	139306464	A	A	139306464	2	1	155	1	0	0	0	0	0	0	0	1	12140	1132	40	1		1	PMPCA	9	139306464	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	26407268	139306464	1906967	51	10938											
AS3MT	57412	broad.mit.edu	37	chr10	104638210	104638210	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaattgggttctgccctccaCgtttggtcactgccaatctc	8	13	3	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr10:104638210C>T	uc001kwk.2	+	8	825	c.685C>T	c.(685-687)CGT>TGT	p.R229C	AS3MT_uc001kwj.2_Missense_Mutation_p.R231C|AS3MT_uc009xxh.2_Missense_Mutation_p.R229C	NM_020682	NP_065733	Q9HBK9	AS3MT_HUMAN	arsenic (+3 oxidation state) methyltransferase	229					arsonoacetate metabolic process|toxin metabolic process	cytosol	arsenite methyltransferase activity|methylarsonite methyltransferase activity				0		Colorectal(252;0.122)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;5.87e-09)|all cancers(201;1.58e-07)|BRCA - Breast invasive adenocarcinoma(275;0.223)		CTGCCCTCCACGTTTGGTCAC	0.408													T	104638210	T	T	104638210	3	4	155	1	0	0	0	0	1	0	0	0	1005	536	19	1	715	1	AS3MT	10	104638210	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08		104638210	30896537	52	10939											
OR52I1	390037	broad.mit.edu	37	chr11	4616048	4616048	+	Frame_Shift_Del	DEL	G	-	-													ttgtactatctacctgggatGgcatccatctatgcggcctg							TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr11:4616048delG	uc010qyi.1	+	1	780	c.780delG	c.(778-780)ATGfs	p.M260fs		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	260	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TACCTGGGATGGCATCCATCT	0.507													-	4616048	-	-	4616048	7	5	155	1	0	1	0	1	0	0	0	0	11120	1348	47	0	782	0	OR52I1	11	4616048	Frame_Shift_Del	DEL	G	TCGA-19-2620-01A-01D-1495-08		4616048	130390468	53	10940											
OR5D18	219438	broad.mit.edu	37	chr11	55587445	55587445	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cctttgtggtcactgaatccTttttattagctgtgatggcc	9	9	1	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr11:55587445T>A	uc010rin.1	+	1	340	c.340T>A	c.(340-342)TTT>ATT	p.F114I		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CACTGAATCCTTTTTATTAGC	0.433													A	55587445	A	A	55587445	3	1	155	1	0	0	0	0	1	0	0	0	11157	1609	56	5	342	5	OR5D18	11	55587445	Missense_Mutation	SNP	T	TCGA-19-2620-01A-01D-1495-08	50971397	55587445	79419071	54	10941											
ACRV1	56	broad.mit.edu	37	chr11	125542539	125542539	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagcatataatttgcatcctCgttccatgggagaagaggtt	10	8	0	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr11:125542539C>T	uc001qcs.2	-	4	1014	c.747G>A	c.(745-747)ACG>ACA	p.T249T	CHEK1_uc001qcf.3_Intron|ACRV1_uc001qck.2_Silent_p.T160T|ACRV1_uc001qcl.2_Silent_p.T179T|ACRV1_uc001qcm.2_Silent_p.T105T|ACRV1_uc001qcn.2_Silent_p.T194T|ACRV1_uc001qco.2_Silent_p.T154T|ACRV1_uc001qcp.2_Silent_p.T65T|ACRV1_uc001qcq.2_Silent_p.T139T|ACRV1_uc001qcr.2_Silent_p.T230T	NM_001612	NP_001603	P26436	ASPX_HUMAN	acrosomal vesicle protein 1 isoform a precursor	249					multicellular organismal development	acrosomal vesicle					0	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0179)|Lung NSC(97;0.0185)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0713)		TTTGCATCCTCGTTCCATGGG	0.448													T	125542539	T	T	125542539	2	4	155	1	0	0	0	0	0	0	0	1	172	871	31	2		2	ACRV1	11	125542539	Silent	SNP	C	TCGA-19-2620-01A-01D-1495-08	69955094	125542539	9463977	55	10942											
ADAMTS20	80070	broad.mit.edu	37	chr12	43833726	43833726	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aataagttctttctcttgtcGattagtactattaattcttt	4	6	3	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr12:43833726G>A	uc010skx.1	-	17	2437	c.2437C>T	c.(2437-2439)CGA>TGA	p.R813*	ADAMTS20_uc001rno.1_5'Flank|ADAMTS20_uc001rnp.1_5'Flank	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	813	Spacer.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TTCTCTTGTCGATTAGTACTA	0.299													A	43833726	A	A	43833726	4	1	155	1	0	0	0	0	0	1	0	0	266	1066	37	2	3386	2	ADAMTS20	12	43833726	Nonsense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08		43833726	90018169	56	10943											
H1FNT	341567	broad.mit.edu	37	chr12	48723149	48723149	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtggggccatggctgaggcGcctgggcccagtggcgaatc	18	11	0	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr12:48723149G>A	uc001rrm.2	+	1	387	c.75G>A	c.(73-75)GCG>GCA	p.A25A		NM_181788	NP_861453	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	25					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			pancreas(1)	1						TGGCTGAGGCGCCTGGGCCCA	0.657													A	48723149	A	A	48723149	2	1	155	1	0	0	0	0	0	0	0	1	6921	1074	38	1		1	H1FNT	12	48723149	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	4889423	48723149	85128746	57	10944											
B4GALNT1	2583	broad.mit.edu	37	chr12	58022670	58022670	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggcaatcgtgactagagcGctgatgttgtactgggctga	15	7	0	4			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr12:58022670G>A	uc001spg.1	-	8	1260	c.828C>T	c.(826-828)AGC>AGT	p.S276S	B4GALNT1_uc010sru.1_Silent_p.S221S|B4GALNT1_uc010srv.1_Silent_p.S243S	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	276	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TGACTAGAGCGCTGATGTTGT	0.577													A	58022670	A	A	58022670	2	1	155	1	0	0	0	0	0	0	0	1	1266	1078	38	1		1	B4GALNT1	12	58022670	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	9299521	58022670	75829225	58	10945											
PTPN11	5781	broad.mit.edu	37	chr12	112926910	112926910	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atggtccagacagaagcacaGtaccgatttatctatatggc	9	9	1	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr12:112926910G>C	uc001ttx.2	+	13	1910	c.1530G>C	c.(1528-1530)CAG>CAC	p.Q510H		NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	514	Tyrosine-protein phosphatase.		Q -> P (in LEOPARD1).		axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding	p.Q510K(2)|p.Q510H(1)		haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						CAGAAGCACAGTACCGATTTA	0.493			Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				C	112926910	C	C	112926910	3	2	155	1	0	0	0	0	1	0	0	0	12780	1020	36	5	1580	5	PTPN11	12	112926910	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	54904240	112926910	20924985	59	10946											
C12orf52	84934	broad.mit.edu	37	chr12	113629392	113629392	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttacactcttcacgccccCtgaagcggggactttcccat	9	15	2	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr12:113629392C>T	uc001tur.1	+	4	1048	c.580C>T	c.(580-582)CTG>TTG	p.L194L	C12orf52_uc009zwg.1_Silent_p.L191L|C12orf52_uc001tus.1_Silent_p.L194L|C12orf52_uc001tut.1_Silent_p.L218L	NM_032848	NP_116237	Q96K30	RITA_HUMAN	hypothetical protein LOC84934	194	Interaction with tubulin.				negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding				0						TTCACGCCCCCTGAAGCGGGG	0.607													T	113629392	T	T	113629392	2	4	155	1	0	0	0	0	0	0	0	1	1697	680	24	3		3	C12orf52	12	113629392	Silent	SNP	C	TCGA-19-2620-01A-01D-1495-08	702482	113629392	20222503	60	10947											
DNAH10	196385	broad.mit.edu	37	chr12	124393905	124393905	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggaaaacagccaagggcGtgatgtccgacccgaatttc	11	11	0	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr12:124393905G>A	uc001uft.3	+	57	9584	c.9559G>A	c.(9559-9561)GTG>ATG	p.V3187M		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3187	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGCCAAGGGCGTGATGTCCGA	0.502													A	124393905	A	A	124393905	3	1	155	1	0	0	0	0	1	0	0	0	4598	1145	40	1	9785	1	DNAH10	12	124393905	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	10764513	124393905	9457990	61	10948											
GPR133	283383	broad.mit.edu	37	chr12	131475583	131475583	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcatgctttattgtcttcaaCgctgccaagcctcttcatga	7	12	4	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr12:131475583C>T	uc001uit.3	+	7	1329	c.770C>T	c.(769-771)ACG>ATG	p.T257M	GPR133_uc010tbm.1_Missense_Mutation_p.T289M	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	257	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TTGTCTTCAACGCTGCCAAGC	0.478													T	131475583	T	T	131475583	3	4	155	1	0	0	0	0	1	0	0	0	6643	536	19	1	796	1	GPR133	12	131475583	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	7081678	131475583	2376312	62	10949											
MDGA2	161357	broad.mit.edu	37	chr14	47389235	47389235	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcctgatgcccaaccggtAtgcaacaatccgatccactg	8	15	0	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr14:47389235A>G	uc001wwj.3	-	10	2207	c.2011T>C	c.(2011-2013)TAC>CAC	p.Y671H	MDGA2_uc001wwi.3_Missense_Mutation_p.Y442H|MDGA2_uc010ani.2_Missense_Mutation_p.Y231H	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	671					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CCCAACCGGTATGCAACAATC	0.423													G	47389235	G	G	47389235	3	3	155	1	0	0	0	0	1	0	0	0	9407	449	16	4	891	4	MDGA2	14	47389235	Missense_Mutation	SNP	A	TCGA-19-2620-01A-01D-1495-08		47389235	59960305	63	10950											
SYNE2	23224	broad.mit.edu	37	chr14	64686074	64686074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagctggaaatgttaaagatGgcaaagcctccctctgatat	10	8	1	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr14:64686074G>A	uc001xgm.2	+	109	19967	c.19737G>A	c.(19735-19737)ATG>ATA	p.M6579I	SYNE2_uc001xgl.2_Missense_Mutation_p.M6602I|SYNE2_uc010apy.2_Missense_Mutation_p.M2964I|SYNE2_uc001xgn.2_Missense_Mutation_p.M1541I|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.M549I|SYNE2_uc001xgq.2_Missense_Mutation_p.M944I|SYNE2_uc001xgr.2_Missense_Mutation_p.M362I|SYNE2_uc010tsi.1_Missense_Mutation_p.M236I|SYNE2_uc001xgs.2_Missense_Mutation_p.M236I|SYNE2_uc001xgt.2_Missense_Mutation_p.M110I	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6579	Cytoplasmic (Potential).|Spectrin 9.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGTTAAAGATGGCAAAGCCTC	0.433													A	64686074	A	A	64686074	3	1	155	1	0	0	0	0	1	0	0	0	15443	1348	47	3	20240	3	SYNE2	14	64686074	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	17296839	64686074	42663466	64	10951											
LTBP2	4053	broad.mit.edu	37	chr14	75078500	75078500	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggcgccgcagtcgattcgCgtctccaccagccggctcgt	13	16	1	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr14:75078500C>T	uc001xqa.2	-	1	535	c.148G>A	c.(148-150)GCG>ACG	p.A50T		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	50					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGTCGATTCGCGTCTCCACCA	0.692													T	75078500	T	T	75078500	3	4	155	1	0	0	0	0	1	0	0	0	9074	768	27	1	5461	1	LTBP2	14	75078500	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	10392426	75078500	32271040	65	10952											
AK7	122481	broad.mit.edu	37	chr14	96875256	96875256	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgacggtgatgacttgggCgcgctccaaagccctggacc	14	13	0	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr14:96875256C>T	uc001yfn.2	+	4	520	c.476C>T	c.(475-477)GCG>GTG	p.A159V		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	159	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		ATGACTTGGGCGCGCTCCAAA	0.473													T	96875256	T	T	96875256	3	4	155	1	0	0	0	0	1	0	0	0	444	768	27	1	490	1	AK7	14	96875256	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	21796756	96875256	10474284	66	10953											
PACS2	23241	broad.mit.edu	37	chr14	105859121	105859121	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agcaggctgcccagcagcggCgaggctgcagccacgcccac	14	17	0	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr14:105859121C>G	uc001yqt.2	+	22	2551	c.2376C>G	c.(2374-2376)GGC>GGG	p.G792G	PACS2_uc001yqs.2_Silent_p.G717G|PACS2_uc001yqv.2_Silent_p.G796G|PACS2_uc001yqu.2_Silent_p.G807G	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	792					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		CCAGCAGCGGCGAGGCTGCAG	0.612													G	105859121	G	G	105859121	2	3	155	1	0	0	0	0	0	0	0	1	11373	755	27	5		5	PACS2	14	105859121	Silent	SNP	C	TCGA-19-2620-01A-01D-1495-08	8983865	105859121	1490419	67	10954											
TRPM1	4308	broad.mit.edu	37	chr15	31295059	31295059	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctattgatgctgctttgccGgagaagatacgttgcctcac	11	10	1	3			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr15:31295059G>A	uc001zfm.2	-	27	3906	c.3778C>T	c.(3778-3780)CGG>TGG	p.R1260W	TRPM1_uc010azy.2_Missense_Mutation_p.R1167W|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1260	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CTGCTTTGCCGGAGAAGATAC	0.473													A	31295059	A	A	31295059	3	1	155	1	0	0	0	0	1	0	0	0	16582	1115	39	2	1037	2	TRPM1	15	31295059	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08		31295059	71236333	68	10955											
FBXL16	146330	broad.mit.edu	37	chr16	745854	745854	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcaggctggaccacagccCggcctcggtgaagtcgttgc	14	14	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr16:745854C>T	uc002cjc.2	-	4	906	c.703G>A	c.(703-705)GGG>AGG	p.G235R	FBXL16_uc002cja.2_5'Flank|FBXL16_uc002cjb.2_Missense_Mutation_p.G23R	NM_153350	NP_699181	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	235											0		Hepatocellular(780;0.0218)				GACCACAGCCCGGCCTCGGTG	0.672													T	745854	T	T	745854	3	4	155	1	0	0	0	0	1	0	0	0	5712	652	23	2	752	2	FBXL16	16	745854	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08		745854	89608899	69	10956											
CHTF18	63922	broad.mit.edu	37	chr16	839297	839297	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ggagccgccccctcccgactCctcgccgacggacatcaccc	9	22	1	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr16:839297C>G	uc002cke.3	+	3	437	c.374C>G	c.(373-375)TCC>TGC	p.S125C	RPUSD1_uc002cka.2_5'Flank|RPUSD1_uc002ckb.2_5'Flank|RPUSD1_uc002ckc.2_5'Flank|RPUSD1_uc002ckd.2_5'Flank|CHTF18_uc010uus.1_Missense_Mutation_p.S125C|CHTF18_uc010bre.1_RNA|CHTF18_uc002ckf.3_Missense_Mutation_p.S153C|CHTF18_uc010brf.2_5'UTR|CHTF18_uc002ckg.3_Intron	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	125					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)				CCTCCCGACTCCTCGCCGACG	0.662													G	839297	G	G	839297	3	3	155	1	0	0	0	0	1	0	0	0	3414	855	30	5	384	5	CHTF18	16	839297	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	93443	839297	89515456	70	10957											
GP2	2813	broad.mit.edu	37	chr16	20328646	20328646	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	actgagaaccggctttccgaGgactgcccattctcctccac	8	16	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr16:20328646G>T	uc002dgv.2	-	9	1397	c.1314C>A	c.(1312-1314)TCC>TCA	p.S438S	GP2_uc002dgw.2_Silent_p.S435S|GP2_uc002dgx.2_Silent_p.S291S|GP2_uc002dgy.2_Silent_p.S288S	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	438	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						GGCTTTCCGAGGACTGCCCAT	0.468													T	20328646	T	T	20328646	2	4	155	1	0	0	0	0	0	0	0	1	6582	987	35	5		5	GP2	16	20328646	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	19489349	20328646	70026107	71	10958											
DNAH3	55567	broad.mit.edu	37	chr16	21053361	21053361	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatttaccttgagattgtcGggcagttcagccctgccagc	11	12	1	1	rs150869091	byFrequency	TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr16:21053361G>A	uc010vbe.1	-	32	4626	c.4626C>T	c.(4624-4626)CCC>CCT	p.P1542P		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1542	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TGAGATTGTCGGGCAGTTCAG	0.403													A	21053361	A	A	21053361	2	1	155	1	0	0	0	0	0	0	0	1	4603	1103	39	2		2	DNAH3	16	21053361	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	724715	21053361	69301392	72	10959											
ZNF423	23090	broad.mit.edu	37	chr16	49671646	49671646	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggcagagatgttgccaaactGcatcacagggtaggcatggt	14	8	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr16:49671646G>C	uc002efs.2	-	5	1715	c.1417C>G	c.(1417-1419)CAG>GAG	p.Q473E	ZNF423_uc010vgn.1_Missense_Mutation_p.Q356E	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	473					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TTGCCAAACTGCATCACAGGG	0.577													C	49671646	C	C	49671646	3	2	155	1	0	0	0	0	1	0	0	0	17895	1328	46	5	2457	5	ZNF423	16	49671646	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	28618285	49671646	40683107	73	10960											
OR1D2	4991	broad.mit.edu	37	chr17	2995386	2995386	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	taaagtgtttatctaggagtCttcccagagccccatgcatg	9	10	2	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr17:2995386C>A	uc010vrb.1	-	1	905	c.905G>T	c.(904-906)AGA>ATA	p.R302I		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	302	Cytoplasmic (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						ATCTAGGAGTCTTCCCAGAGC	0.463													A	2995386	A	A	2995386	3	1	155	1	0	0	0	0	1	0	0	0	10953	913	32	5	36	5	OR1D2	17	2995386	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08		2995386	78199824	74	10961											
NF1	4763	broad.mit.edu	37	chr17	29508439	29508439	+	Splice_Site	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	taaaaattgtgttttttccaGaaacagcatttaaatttaaa	4	4	0	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr17:29508439G>A	uc002hgg.2	+	6	920	c.587_splice	c.e6-1	p.E196_splice	NF1_uc002hge.1_Splice_Site_p.E196_splice|NF1_uc002hgf.1_Splice_Site_p.E196_splice|NF1_uc002hgh.2_Splice_Site_p.E196_splice|NF1_uc010csn.1_Splice_Site_p.E56_splice	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GTTTTTTCCAGAAACAGCATT	0.299			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29508439	A	A	29508439	5	1	155	1	0	0	0	0	0	0	1	0	10356	956	33	3	608	3	NF1	17	29508439	Splice_Site	SNP	G	TCGA-19-2620-01A-01D-1495-08	26513053	29508439	51686771	75	10962											
WNT9B	7484	broad.mit.edu	37	chr17	44949992	44949992	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgctgaagctgtcccggCggcagaagcagctctgccgg	14	14	1	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr17:44949992C>T	uc002ikw.1	+	2	224	c.187C>T	c.(187-189)CGG>TGG	p.R63W	WNT9B_uc002ikx.1_Missense_Mutation_p.R63W	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	63					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GCTGTCCCGGCGGCAGAAGCA	0.682													T	44949992	T	T	44949992	3	4	155	1	0	0	0	0	1	0	0	0	17396	759	27	1	193	1	WNT9B	17	44949992	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	15441553	44949992	36245218	76	10963											
IGF2BP1	10642	broad.mit.edu	37	chr17	47118832	47118832	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaacctgaagaaggtagagcAagataccgagacaaaaatca	10	7	1	5			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr17:47118832A>C	uc002iom.2	+	8	1245	c.911A>C	c.(910-912)CAA>CCA	p.Q304P	IGF2BP1_uc010dbj.2_Missense_Mutation_p.Q165P	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	304	Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).|KH 2.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						AAGGTAGAGCAAGATACCGAG	0.498													C	47118832	C	C	47118832	3	2	155	1	0	0	0	0	1	0	0	0	7573	130	5	5	941	5	IGF2BP1	17	47118832	Missense_Mutation	SNP	A	TCGA-19-2620-01A-01D-1495-08	2168840	47118832	34076378	77	10964											
SDK2	54549	broad.mit.edu	37	chr17	71418469	71418469	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctttccccacgtcgttgaCggcacaaagacggaactggt	10	13	0	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr17:71418469C>T	uc010dfm.2	-	15	2002	c.2002G>A	c.(2002-2004)GTC>ATC	p.V668I	SDK2_uc010dfn.2_Missense_Mutation_p.V347I	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	668	Extracellular (Potential).|Fibronectin type-III 1.				cell adhesion	integral to membrane				ovary(2)	2						ACGTCGTTGACGGCACAAAGA	0.617													T	71418469	T	T	71418469	3	4	155	1	0	0	0	0	1	0	0	0	13969	536	19	1	4640	1	SDK2	17	71418469	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	24299637	71418469	9776741	78	10965											
LAMA1	284217	broad.mit.edu	37	chr18	6999962	6999962	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acaggcgtcacaacggaaatCgtggtccccttccaagacac	9	14	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr18:6999962C>T	uc002knm.2	-	31	4511	c.4417G>A	c.(4417-4419)GAT>AAT	p.D1473N	LAMA1_uc010wzj.1_Missense_Mutation_p.D949N	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1473	Laminin EGF-like 16.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAACGGAAATCGTGGTCCCCT	0.423													T	6999962	T	T	6999962	3	4	155	1	0	0	0	0	1	0	0	0	8605	884	31	2	4942	2	LAMA1	18	6999962	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08		6999962	71077286	79	10966											
RIOK3	8780	broad.mit.edu	37	chr18	21043044	21043044	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgtttttcctgaagttgcGtaagtaaaattcacaaatac	7	8	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr18:21043044G>A	uc002kui.3	+	2	796	c.179_splice	c.e2+1	p.A60_splice	RIOK3_uc010dls.2_Splice_Site_p.A60_splice|RIOK3_uc010xas.1_Splice_Site_p.A60_splice	NM_003831	NP_003822	O14730	RIOK3_HUMAN	sudD suppressor of bimD6 homolog						chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CTGAAGTTGCGTAAGTAAAAT	0.348													A	21043044	A	A	21043044	5	1	155	1	0	0	0	0	0	0	1	0	13379	1159	40	1	186	1	RIOK3	18	21043044	Splice_Site	SNP	G	TCGA-19-2620-01A-01D-1495-08	14043082	21043044	57034204	80	10967											
DOCK6	57572	broad.mit.edu	37	chr19	11353971	11353971	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgacagttagcgtggctggaCggaagccagagaagctgcag	16	8	0	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr19:11353971C>T	uc002mqs.3	-	12	1390	c.1349G>A	c.(1348-1350)CGT>CAT	p.R450H		NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	450					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CGTGGCTGGACGGAAGCCAGA	0.677											OREG0025252	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	11353971	T	T	11353971	3	4	155	1	0	0	0	0	1	0	0	0	4691	536	19	1	4942	1	DOCK6	19	11353971	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08		11353971	47775012	81	10968											
OR7A10	390892	broad.mit.edu	37	chr19	14952342	14952342	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaccggtcataggccatcacGgtcagaaggaagttatccaa	10	10	3	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr19:14952342G>A	uc002mzx.1	-	1	348	c.348C>T	c.(346-348)ACC>ACT	p.T116T		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					AGGCCATCACGGTCAGAAGGA	0.483													A	14952342	A	A	14952342	2	1	155	1	0	0	0	0	0	0	0	1	11214	1103	39	2		2	OR7A10	19	14952342	Silent	SNP	G	TCGA-19-2620-01A-01D-1495-08	3598371	14952342	44176641	82	10969											
FCGBP	8857	broad.mit.edu	37	chr19	40364217	40364217	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgctcacactcagggcccgGgtagaagacctcgcccagtg	12	16	2	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr19:40364217G>A	uc002omp.3	-	31	14433	c.14425C>T	c.(14425-14427)CCG>TCG	p.P4809S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4809						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCAGGGCCCGGGTAGAAGACC	0.657													A	40364217	A	A	40364217	3	1	155	1	0	0	0	0	1	0	0	0	5778	1232	43	3	1816	3	FCGBP	19	40364217	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	25411875	40364217	18764766	83	10970											
EML2	24139	broad.mit.edu	37	chr19	46112931	46112931	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggccgcatcagaccaccCgccactgtagcacactggtg	10	17	1	1			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr19:46112931C>T	uc002pcn.2	-	19	1975	c.1940G>A	c.(1939-1941)CGG>CAG	p.R647Q	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Missense_Mutation_p.R531Q|EML2_uc010xxl.1_Missense_Mutation_p.R794Q|EML2_uc010xxm.1_Missense_Mutation_p.R848Q	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	647	WD 11.				sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		TCAGACCACCCGCCACTGTAG	0.537													T	46112931	T	T	46112931	3	4	155	1	0	0	0	0	1	0	0	0	5097	652	23	2	13	2	EML2	19	46112931	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	5748714	46112931	13016052	84	10971											
ELSPBP1	64100	broad.mit.edu	37	chr19	48525436	48525436	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcttcctaggaatttccgCgttggtccctggctttcctt	9	13	0	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr19:48525436C>T	uc002pht.2	+	6	679	c.524C>T	c.(523-525)GCG>GTG	p.A175V		NM_022142	NP_071425	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1 precursor	175					single fertilization	extracellular region					0		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		GGAATTTCCGCGTTGGTCCCT	0.453													T	48525436	T	T	48525436	3	4	155	1	0	0	0	0	1	0	0	0	5083	768	27	1	542	1	ELSPBP1	19	48525436	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08	2412505	48525436	10603547	85	10972											
PROKR2	128674	broad.mit.edu	37	chr20	5282952	5282952	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggggaagaagtcacgaaCgatggtgaaaccgtagaagg	16	5	1	3	rs139399061	byFrequency	TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr20:5282952C>T	uc010zqw.1	-	2	889	c.889G>A	c.(889-891)GTT>ATT	p.V297I	PROKR2_uc010zqx.1_Missense_Mutation_p.V297I|PROKR2_uc010zqy.1_Missense_Mutation_p.V297I	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	297	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						AAGTCACGAACGATGGTGAAA	0.562										HNSCC(71;0.22)			T	5282952	T	T	5282952	3	4	155	1	0	0	0	0	1	0	0	0	12553	536	19	1	268	1	PROKR2	20	5282952	Missense_Mutation	SNP	C	TCGA-19-2620-01A-01D-1495-08		5282952	57742568	86	10973											
SYCP2	10388	broad.mit.edu	37	chr20	58489299	58489299	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tctacaatgcctacctgtaaGtcataatctattaaaaaaat	3	8	3	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr20:58489299G>T	uc002yaz.2	-	10	781	c.642C>A	c.(640-642)GAC>GAA	p.D214E	SYCP2_uc010gju.1_Missense_Mutation_p.D115E	NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	214					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			CTACCTGTAAGTCATAATCTA	0.289													T	58489299	T	T	58489299	3	4	155	1	0	0	0	0	1	0	0	0	15429	1020	36	5	4090	5	SYCP2	20	58489299	Missense_Mutation	SNP	G	TCGA-19-2620-01A-01D-1495-08	53206347	58489299	4536221	87	10974											
ARFGAP1	55738	broad.mit.edu	37	chr20	61907550	61907550	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cgcgggcttggggttcacctCaggtcagtgtcctgccgctc	14	14	3	0			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chr20:61907550C>A	uc002yem.2	+	3	280	c.168C>A	c.(166-168)CTC>CTA	p.L56L	ARFGAP1_uc011aas.1_Intron|ARFGAP1_uc011aat.1_5'UTR|ARFGAP1_uc002yel.2_Silent_p.L56L|ARFGAP1_uc002yen.2_Silent_p.L56L	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	56	Arf-GAP.				COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					GGGTTCACCTCAGGTCAGTGT	0.642													A	61907550	A	A	61907550	2	1	155	1	0	0	0	0	0	0	0	1	849	813	29	5		5	ARFGAP1	20	61907550	Silent	SNP	C	TCGA-19-2620-01A-01D-1495-08	3418251	61907550	1117970	88	10975											
KLHL13	90293	broad.mit.edu	37	chrX	117043736	117043736	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagttctcatgaaatccacCgtttgcacgtaattaatgag	7	9	2	2			TCGA-19-2620-01A-01D-1495-08	TCGA-19-2620-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	6de41ac1-229b-40b9-a494-5588c284351d	ede6d42c-895a-46f7-a0e3-11b152970581	g.chrX:117043736C>T	uc004eql.2	-	5	956	c.894G>A	c.(892-894)ACG>ACA	p.T298T	KLHL13_uc004eqk.2_Silent_p.T247T|KLHL13_uc011mtn.1_Silent_p.T138T|KLHL13_uc011mto.1_Silent_p.T292T|KLHL13_uc011mtp.1_Silent_p.T300T|KLHL13_uc004eqm.2_Silent_p.T247T|KLHL13_uc011mtq.1_Silent_p.T282T	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	298					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						TGAAATCCACCGTTTGCACGT	0.423													T	117043736	T	T	117043736	2	4	155	1	0	0	0	0	0	0	0	1	8369	639	23	2		2	KLHL13	23	117043736	Silent	SNP	C	TCGA-19-2620-01A-01D-1495-08		117043736	38226824	89	10976											
TAS1R1	80835	broad.mit.edu	37	chr1	6631015	6631015	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accacctcttccaggctatgCggcttggggttgaggagata	13	10	1	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:6631015C>T	uc001ant.2	+	2	238	c.238C>T	c.(238-240)CGG>TGG	p.R80W	TAS1R1_uc001anu.2_Missense_Mutation_p.R80W|TAS1R1_uc001anv.2_Missense_Mutation_p.R80W|TAS1R1_uc001anw.2_Missense_Mutation_p.R80W	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	80	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CCAGGCTATGCGGCTTGGGGT	0.532													T	6631015	T	T	6631015	3	4	156	1	0	0	0	0	1	0	0	0	15559	759	27	1	244	1	TAS1R1	1	6631015	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08		6631015	242619606	1	10977											
RERE	473	broad.mit.edu	37	chr1	8419927	8419927	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggctttctgctcagcctcgCgcttggccttctcaatggcc	11	15	3	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:8419927C>T	uc001ape.2	-	20	4325	c.3515G>A	c.(3514-3516)CGC>CAC	p.R1172H	RERE_uc001apf.2_Missense_Mutation_p.R1172H|RERE_uc001apd.2_Missense_Mutation_p.R618H	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1172	Potential.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CTCAGCCTCGCGCTTGGCCTT	0.498													T	8419927	T	T	8419927	3	4	156	1	0	0	0	0	1	0	0	0	13231	768	27	1	1205	1	RERE	1	8419927	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	1788912	8419927	240830694	2	10978											
HTR6	3362	broad.mit.edu	37	chr1	19992747	19992747	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccctgctgctgggctggcaCgagctgggccacgcacggcc	15	17	0	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:19992747C>T	uc001bcl.2	+	1	968	c.501C>T	c.(499-501)CAC>CAT	p.H167H		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	167	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	TGGGCTGGCACGAGCTGGGCC	0.711													T	19992747	T	T	19992747	2	4	156	1	0	0	0	0	0	0	0	1	7451	535	19	1		1	HTR6	1	19992747	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08	11572820	19992747	229257874	3	10979											
RNF19B	127544	broad.mit.edu	37	chr1	33402782	33402782	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaacatggagcgagtcctcCgtgctgcttccactcaccag	10	14	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:33402782C>T	uc010oho.1	-	9	1824	c.1824G>A	c.(1822-1824)ACG>ACA	p.T608T	RNF19B_uc001bwm.3_3'UTR|RNF19B_uc010ohp.1_Silent_p.T607T	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	608						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCGAGTCCTCCGTGCTGCTTC	0.502													T	33402782	T	T	33402782	2	4	156	1	0	0	0	0	0	0	0	1	13471	639	23	2		2	RNF19B	1	33402782	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08	13410035	33402782	215847839	4	10980											
COL9A2	1298	broad.mit.edu	37	chr1	40770007	40770007	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcaccttgtctcctttgacGcctggcaagccttggggccc	12	15	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:40770007G>A	uc001cfh.1	-	24	1342	c.1272C>T	c.(1270-1272)GGC>GGT	p.G424G	COL9A2_uc001cfi.1_Silent_p.G243G	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	424	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CTCCTTTGACGCCTGGCAAGC	0.607													A	40770007	A	A	40770007	2	1	156	1	0	0	0	0	0	0	0	1	3708	1074	38	1		1	COL9A2	1	40770007	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	7367225	40770007	208480614	5	10981											
LRRC7	57554	broad.mit.edu	37	chr1	70504762	70504762	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gaagtgaaagccgaaaagagGataccacccccttttcaaca	8	11	1	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:70504762G>C	uc001dep.2	+	19	3171	c.3141G>C	c.(3139-3141)AGG>AGC	p.R1047S	LRRC7_uc009wbg.2_Missense_Mutation_p.R331S|LRRC7_uc001deq.2_Missense_Mutation_p.R288S	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1047						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CCGAAAAGAGGATACCACCCC	0.448													C	70504762	C	C	70504762	3	2	156	1	0	0	0	0	1	0	0	0	9020	1165	41	5	3215	5	LRRC7	1	70504762	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	29734755	70504762	178745859	6	10982											
PTGFR	5737	broad.mit.edu	37	chr1	78958623	78958623	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agacagaagtccaaggcatcGtttctgcttttggccagtgg	12	9	1	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:78958623G>A	uc001din.2	+	2	461	c.195G>A	c.(193-195)TCG>TCA	p.S65S	PTGFR_uc001dim.2_Silent_p.S65S	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	65	Cytoplasmic (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CCAAGGCATCGTTTCTGCTTT	0.423													A	78958623	A	A	78958623	2	1	156	1	0	0	0	0	0	0	0	1	12749	1132	40	1		1	PTGFR	1	78958623	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	8453861	78958623	170291998	7	10983											
GBP4	115361	broad.mit.edu	37	chr1	89650937	89650937	+	Nonstop_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tacctggaatattcaggctcTtaaatacgtgagccaagata	8	8	2	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:89650937T>A	uc001dnb.2	-	11	2039	c.1923A>T	c.(1921-1923)TAA>TAT	p.*641Y		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	641						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		ATTCAGGCTCTTAAATACGTG	0.343													A	89650937	A	A	89650937	4	1	156	1	0	0	0	0	0	0	0	0	6276	1616	56	5	3	5	GBP4	1	89650937	Nonstop_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08	10692314	89650937	159599684	8	10984											
C1orf161	126868	broad.mit.edu	37	chr1	116670945	116670945	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggaacaggccggttatcacGtcccaccatctgcaggtgag	13	12	2	1	rs148441950		TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:116670945G>A	uc001egc.1	+	6	1105	c.840G>A	c.(838-840)ACG>ACA	p.T280T		NM_152367	NP_689580	Q8N8X9	MB213_HUMAN	hypothetical protein LOC126868	280											0	Lung SC(450;0.184)	all_cancers(81;0.00142)|all_lung(203;0.000139)|all_epithelial(167;0.000401)|Lung NSC(69;0.000705)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CGGTTATCACGTCCCACCATC	0.582													A	116670945	A	A	116670945	2	1	156	1	0	0	0	0	0	0	0	1	2009	1132	40	1		1	C1orf161	1	116670945	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	27020008	116670945	132579676	9	10985											
NBPF9	400818	broad.mit.edu	37	chr1	144823890	144823890	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tagatgttattcaactccttCaggttgtcttgaactgactg	8	8	3	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:144823890C>G	uc009wig.1	+	17	2007	c.1931C>G	c.(1930-1932)TCA>TGA	p.S644*	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Nonsense_Mutation_p.S445*|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|NBPF9_uc001elp.2_Nonsense_Mutation_p.S304*	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	644	NBPF 4.					cytoplasm					0						TCAACTCCTTCAGGTTGTCTT	0.483													G	144823890	G	G	144823890	4	3	156	1	0	0	0	0	0	1	0	0	10199	838	29	5	1983	5	NBPF9	1	144823890	Nonsense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	28152945	144823890	104426731	10	10986											
FLG	2312	broad.mit.edu	37	chr1	152283564	152283564	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcctggctaacactggatccCtggtgcctgcttgtcctgga	11	13	0	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:152283564C>A	uc001ezu.1	-	3	3834	c.3798G>T	c.(3796-3798)CAG>CAT	p.Q1266H	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1266	Ser-rich.|Filaggrin 7.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACTGGATCCCTGGTGCCTGC	0.488									Ichthyosis				A	152283564	A	A	152283564	3	1	156	1	0	0	0	0	1	0	0	0	5922	680	24	5	8391	5	FLG	1	152283564	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	7459674	152283564	96967057	11	10987											
OR6N2	81442	broad.mit.edu	37	chr1	158746549	158746549	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttaatgatttccttgttacGaagactgtagataattggat	8	4	0	3	rs144962739		TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:158746549G>A	uc010pir.1	-	1	877	c.877C>T	c.(877-879)CGT>TGT	p.R293C		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TCCTTGTTACGAAGACTGTAG	0.418													A	158746549	A	A	158746549	3	1	156	1	0	0	0	0	1	0	0	0	11207	1058	37	2	79	2	OR6N2	1	158746549	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	6462985	158746549	90504072	12	10988											
IGSF8	93185	broad.mit.edu	37	chr1	160064843	160064843	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gacttgaagacagcataggaGaactgggtatccttggtact	12	7	0	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:160064843G>A	uc001fva.2	-	2	303	c.258C>T	c.(256-258)TTC>TTT	p.F86F	IGSF8_uc001fuz.2_Silent_p.F86F|IGSF8_uc009wtf.2_Silent_p.F86F	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	86	Ig-like C2-type 1.|Extracellular (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CAGCATAGGAGAACTGGGTAT	0.602													A	160064843	A	A	160064843	2	1	156	1	0	0	0	0	0	0	0	1	7604	933	33	3		3	IGSF8	1	160064843	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	1318294	160064843	89185778	13	10989											
SEC16B	89866	broad.mit.edu	37	chr1	177927423	177927423	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgatgaggttggccacaggGggctgccgcttgtacttctc	14	10	1	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:177927423G>A	uc001gli.1	-	10	1299	c.1209C>T	c.(1207-1209)CCC>CCT	p.P403P	SEC16B_uc001glk.1_Silent_p.P80P|SEC16B_uc001glh.1_Silent_p.P62P|SEC16B_uc009wwz.1_Silent_p.P62P|SEC16B_uc001glj.1_Silent_p.P404P|SEC16B_uc001gll.3_Silent_p.P404P	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	403					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						TGGCCACAGGGGGCTGCCGCT	0.587													A	177927423	A	A	177927423	2	1	156	1	0	0	0	0	0	0	0	1	13987	1219	43	3		3	SEC16B	1	177927423	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	17862580	177927423	71323198	14	10990											
GPATCH2	55105	broad.mit.edu	37	chr1	217688167	217688167	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacactgagtactcactcaTggtgatgagaatccggggaa	11	9	2	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:217688167T>C	uc001hlf.1	-	6	1259	c.1163A>G	c.(1162-1164)CAT>CGT	p.H388R		NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	388						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		TACTCACTCATGGTGATGAGA	0.353													C	217688167	C	C	217688167	3	2	156	1	0	0	0	0	1	0	0	0	6591	1464	51	4	443	4	GPATCH2	1	217688167	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08	39760744	217688167	31562454	15	10991											
NVL	4931	broad.mit.edu	37	chr1	224514105	224514105	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttatttacctgtacactcttTgtaaatcagacgctaagact	5	9	2	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr1:224514105T>C	uc001hok.2	-	2	162	c.119A>G	c.(118-120)CAA>CGA	p.Q40R	NVL_uc001hol.2_Intron|NVL_uc010pvd.1_Missense_Mutation_p.Q40R|NVL_uc010pve.1_Intron|NVL_uc010pvf.1_Intron|NVL_uc010pvg.1_Missense_Mutation_p.Q40R	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	40						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		GTACACTCTTTGTAAATCAGA	0.318													C	224514105	C	C	224514105	3	2	156	1	0	0	0	0	1	0	0	0	10780	1812	63	4	2539	4	NVL	1	224514105	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08	6825938	224514105	24736516	16	10992											
DYSF	8291	broad.mit.edu	37	chr2	71909724	71909724	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccatgaagttcatcctgtggCggcgtttccggtgggccatc	13	12	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:71909724C>T	uc002sie.2	+	54	6497	c.6121C>T	c.(6121-6123)CGG>TGG	p.R2041W	DYSF_uc010feg.2_Missense_Mutation_p.R2072W|DYSF_uc010feh.2_Missense_Mutation_p.R2048W|DYSF_uc002sig.3_Missense_Mutation_p.R2027W|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R2062W|DYSF_uc010fef.2_Missense_Mutation_p.R2079W|DYSF_uc010fei.2_Missense_Mutation_p.R2058W|DYSF_uc010fek.2_Missense_Mutation_p.R2059W|DYSF_uc010fej.2_Missense_Mutation_p.R2049W|DYSF_uc010fel.2_Missense_Mutation_p.R2028W|DYSF_uc010feo.2_Missense_Mutation_p.R2073W|DYSF_uc010fem.2_Missense_Mutation_p.R2063W|DYSF_uc010fen.2_Missense_Mutation_p.R2080W|DYSF_uc002sif.2_Missense_Mutation_p.R2042W|DYSF_uc010yqy.1_Missense_Mutation_p.R922W|DYSF_uc010yqz.1_Missense_Mutation_p.R802W	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	2041	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CATCCTGTGGCGGCGTTTCCG	0.522													T	71909724	T	T	71909724	3	4	156	1	0	0	0	0	1	0	0	0	4859	759	27	1	6594	1	DYSF	2	71909724	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08		71909724	171289649	17	10993											
ASTL	431705	broad.mit.edu	37	chr2	96798441	96798441	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacctgcatccctccactgcGccccacactcgagaagcacc	6	21	0	1	rs145986421		TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:96798441G>A	uc010yui.1	-	6	475	c.475C>T	c.(475-477)CGC>TGC	p.R159C		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	159					proteolysis		metalloendopeptidase activity|zinc ion binding				0						CCTCCACTGCGCCCCACACTC	0.627													A	96798441	A	A	96798441	3	1	156	1	0	0	0	0	1	0	0	0	1063	1087	38	1	835	1	ASTL	2	96798441	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	24888717	96798441	146400932	18	10994											
NEB	4703	broad.mit.edu	37	chr2	152470900	152470900	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tatgtcgcttacaaggatctGacacttcttggccagcacca	8	12	2	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:152470900G>A	uc010fnx.2	-	73	10953	c.10762C>T	c.(10762-10764)CAG>TAG	p.Q3588*		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3588	Nebulin 98.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ACAAGGATCTGACACTTCTTG	0.527													A	152470900	A	A	152470900	4	1	156	1	0	0	0	0	0	1	0	0	10302	1299	45	3	14619	3	NEB	2	152470900	Nonsense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	55672459	152470900	90728473	19	10995											
ZNF804A	91752	broad.mit.edu	37	chr2	185801478	185801478	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttatacaactacgaaaccatCaatttcctatagctgtaatc	3	10	1	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:185801478C>G	uc002uph.2	+	4	1949	c.1355C>G	c.(1354-1356)TCA>TGA	p.S452*		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	452						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						ACGAAACCATCAATTTCCTAT	0.333													G	185801478	G	G	185801478	4	3	156	1	0	0	0	0	0	1	0	0	18167	838	29	5	1369	5	ZNF804A	2	185801478	Nonsense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	33330578	185801478	57397895	20	10996											
COL3A1	1281	broad.mit.edu	37	chr2	189851838	189851838	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagtctggagtagcagtaggAggactcgcaggctatcctgg	15	8	1	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:189851838A>G	uc002uqj.1	+	5	618	c.501A>G	c.(499-501)GGA>GGG	p.G167G		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	167	Nonhelical region (N-terminal).				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TAGCAGTAGGAGGACTCGCAG	0.403													G	189851838	G	G	189851838	2	3	156	1	0	0	0	0	0	0	0	1	3688	291	11	4		4	COL3A1	2	189851838	Silent	SNP	A	TCGA-19-2623-01A-01D-1495-08	4050360	189851838	53347535	21	10997											
COL3A1	1281	broad.mit.edu	37	chr2	189864035	189864035	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgctggtgcccctggtgaaCgtggacctcctggattggca	14	11	0	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:189864035C>A	uc002uqj.1	+	30	2164	c.2047C>A	c.(2047-2049)CGT>AGT	p.R683S		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	683	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCCTGGTGAACGTGGACCTCC	0.493													A	189864035	A	A	189864035	3	1	156	1	0	0	0	0	1	0	0	0	3688	536	19	5	2165	5	COL3A1	2	189864035	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	12197	189864035	53335338	22	10998											
ANKAR	150709	broad.mit.edu	37	chr2	190571779	190571779	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atattaaaggaaataatataAtccatttatcagtgttaacc	4	5	1	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:190571779A>C	uc002uqw.1	+	8	1813	c.1813A>C	c.(1813-1815)ATC>CTC	p.I605L	ANKAR_uc002uqu.2_RNA	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	676	ANK 5.					integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AAATAATATAATCCATTTATC	0.343													C	190571779	C	C	190571779	3	2	156	1	0	0	0	0	1	0	0	0	623	101	4	5	2056	5	ANKAR	2	190571779	Missense_Mutation	SNP	A	TCGA-19-2623-01A-01D-1495-08	707744	190571779	52627594	23	10999											
ZNF142	7701	broad.mit.edu	37	chr2	219507508	219507508	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtacccttaaccggtgcaagCgcagtttcgagttggtacca	11	11	0	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:219507508C>T	uc002vin.2	-	8	4167	c.3731G>A	c.(3730-3732)CGC>CAC	p.R1244H	ZNF142_uc002vil.2_Missense_Mutation_p.R1205H|ZNF142_uc010fvt.2_Missense_Mutation_p.R1081H|ZNF142_uc002vim.2_Missense_Mutation_p.R1081H	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1244	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CCGGTGCAAGCGCAGTTTCGA	0.542													T	219507508	T	T	219507508	3	4	156	1	0	0	0	0	1	0	0	0	17728	768	27	1	1344	1	ZNF142	2	219507508	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	28935729	219507508	23691865	24	11000											
KIAA1486	57624	broad.mit.edu	37	chr2	226447451	226447451	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actccacctctccctcccccGtcagcatggggaggtccctg	9	19	2	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:226447451G>A	uc002voe.2	+	4	1493	c.1318G>A	c.(1318-1320)GTC>ATC	p.V440I	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.V210I	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	440	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		TCCCTCCCCCGTCAGCATGGG	0.642													A	226447451	A	A	226447451	3	1	156	1	0	0	0	0	1	0	0	0	8237	1145	40	1	1328	1	KIAA1486	2	226447451	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	6939943	226447451	16751922	25	11001											
TRPM8	79054	broad.mit.edu	37	chr2	234891861	234891861	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcggccaggtgcccagtgaCgtggatggtaagcctgactt	14	10	0	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr2:234891861C>T	uc002vvh.2	+	20	2794	c.2754C>T	c.(2752-2754)GAC>GAT	p.D918D	TRPM8_uc010fyj.2_Silent_p.D496D|TRPM8_uc010fyk.2_RNA	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	918	Extracellular (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGCCCAGTGACGTGGATGGTA	0.592													T	234891861	T	T	234891861	2	4	156	1	0	0	0	0	0	0	0	1	16589	535	19	1		1	TRPM8	2	234891861	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08	8444410	234891861	8307512	26	11002											
CAND2	23066	broad.mit.edu	37	chr3	12858462	12858462	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccacactggcagccctggaCgccctggcccagagccaggg	14	17	0	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr3:12858462C>T	uc003bxk.2	+	10	2080	c.2031C>T	c.(2029-2031)GAC>GAT	p.D677D	CAND2_uc003bxj.2_Silent_p.D584D	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	677	HEAT 14.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						CAGCCCTGGACGCCCTGGCCC	0.662													T	12858462	T	T	12858462	2	4	156	1	0	0	0	0	0	0	0	1	2616	535	19	1		1	CAND2	3	12858462	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08		12858462	185163968	27	11003											
SCN10A	6336	broad.mit.edu	37	chr3	38748876	38748876	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agatgtcctggccccctaagTgcagagagggccacactgtt	12	12	0	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr3:38748876T>C	uc003ciq.2	-	25	4282	c.4282_splice	c.e25-1	p.L1428_splice		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha						sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GCCCCCTAAGTGCAGAGAGGG	0.512													C	38748876	C	C	38748876	5	2	156	1	0	0	0	0	0	0	1	0	13912	1710	59	4	1602	4	SCN10A	3	38748876	Splice_Site	SNP	T	TCGA-19-2623-01A-01D-1495-08	25890414	38748876	159273554	28	11004											
PCOLCE2	26577	broad.mit.edu	37	chr3	142557612	142557612	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cataaataggtgctacttacGcaggtggactatcaccacaa	8	10	1	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr3:142557612G>A	uc003evd.2	-	5	906	c.710C>T	c.(709-711)GCG>GTG	p.A237V		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	237	CUB 2.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						TGCTACTTACGCAGGTGGACT	0.378													A	142557612	A	A	142557612	3	1	156	1	0	0	0	0	1	0	0	0	11595	1101	38	1	557	1	PCOLCE2	3	142557612	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	103808736	142557612	55464818	29	11005											
GPR78	27201	broad.mit.edu	37	chr4	8582980	8582980	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctggacaccttcctggcgTccaacgcggcgctgagcgtg	13	15	0	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr4:8582980T>C	uc003glk.2	+	1	690	c.271T>C	c.(271-273)TCC>CCC	p.S91P	CPZ_uc003gll.2_RNA	NM_080819	NP_543009	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	91	Helical; Name=3; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|ovary(2)	6						CTTCCTGGCGTCCAACGCGGC	0.706													C	8582980	C	C	8582980	3	2	156	1	0	0	0	0	1	0	0	0	6710	1667	58	4	273	4	GPR78	4	8582980	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08		8582980	182571296	30	11006											
NCAPG	64151	broad.mit.edu	37	chr4	17816578	17816578	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgccaaaaattgtagggcGcaccaaggatgtgaaagagg	13	6	0	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr4:17816578G>A	uc003gpp.2	+	4	823	c.647G>A	c.(646-648)CGC>CAC	p.R216H	NCAPG_uc011bxj.1_5'UTR	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	216					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		ATTGTAGGGCGCACCAAGGAT	0.398													A	17816578	A	A	17816578	3	1	156	1	0	0	0	0	1	0	0	0	10207	1087	38	1	661	1	NCAPG	4	17816578	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	9233598	17816578	173337698	31	11007											
LGI2	55203	broad.mit.edu	37	chr4	25014103	25014103	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaaccgactggtagggtaaaGtctgatgaacaacaaaatct	9	7	2	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr4:25014103G>T	uc003grf.2	-	7	773	c.674C>A	c.(673-675)ACT>AAT	p.T225N		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	225	EAR 1.					extracellular region					0		Breast(46;0.173)				GTAGGGTAAAGTCTGATGAAC	0.473													T	25014103	T	T	25014103	3	4	156	1	0	0	0	0	1	0	0	0	8752	1029	36	5	971	5	LGI2	4	25014103	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	7197525	25014103	166140173	32	11008											
GABRG1	2565	broad.mit.edu	37	chr4	46043100	46043100	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagtcaattttggcaatgcGtatgtgtatccttccttccc	8	10	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr4:46043100G>A	uc003gxb.2	-	9	1455	c.1303C>T	c.(1303-1305)CGC>TGC	p.R435C		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	435	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTGGCAATGCGTATGTGTATC	0.403													A	46043100	A	A	46043100	3	1	156	1	0	0	0	0	1	0	0	0	6171	1145	40	1	98	1	GABRG1	4	46043100	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	21028997	46043100	145111176	33	11009											
UGT2B4	7363	broad.mit.edu	37	chr4	70361563	70361563	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatcagcagaagagctgaaGtccatttcatagacatcctg	9	9	2	4			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr4:70361563G>A	uc003hek.3	-	1	64	c.17C>T	c.(16-18)ACT>ATT	p.T6I	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Missense_Mutation_p.T6I	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	6					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						AAGAGCTGAAGTCCATTTCAT	0.443													A	70361563	A	A	70361563	3	1	156	1	0	0	0	0	1	0	0	0	16958	1029	36	3	1593	3	UGT2B4	4	70361563	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	24318463	70361563	120792713	34	11010											
PF4	5196	broad.mit.edu	37	chr4	74847163	74847163	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagtggggcagtggggtccGgccttgatcacctccaggct	16	12	1	1	rs144253863		TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr4:74847163G>A	uc003hhi.2	-	2	234	c.189C>T	c.(187-189)GCC>GCT	p.A63A		NM_002619	NP_002610	P02776	PLF4_HUMAN	platelet factor 4 (chemokine (C-X-C motif)	63					cytokine-mediated signaling pathway|immune response|leukocyte chemotaxis|negative regulation of angiogenesis|negative regulation of apoptosis|negative regulation of cytolysis|negative regulation of megakaryocyte differentiation|negative regulation of MHC class II biosynthetic process|platelet activation|platelet degranulation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of tumor necrosis factor production	extracellular space|platelet alpha granule lumen	chemokine activity|heparin binding				0	Breast(15;0.00136)		all cancers(17;0.0034)|Lung(101;0.196)		Drotrecogin alfa(DB00055)	AGTGGGGTCCGGCCTTGATCA	0.612													A	74847163	A	A	74847163	2	1	156	1	0	0	0	0	0	0	0	1	11752	1103	39	2		2	PF4	4	74847163	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	4485600	74847163	116307113	35	11011											
MEPE	56955	broad.mit.edu	37	chr4	88766796	88766796	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctcctttcagtggggacgGccaaccttttaaggacattc	9	11	2	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr4:88766796G>A	uc003hqy.2	+	4	815	c.776G>A	c.(775-777)GGC>GAC	p.G259D	MEPE_uc010ikn.2_Missense_Mutation_p.G146D	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	259					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AGTGGGGACGGCCAACCTTTT	0.453													A	88766796	A	A	88766796	3	1	156	1	0	0	0	0	1	0	0	0	9478	1203	42	3	786	3	MEPE	4	88766796	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	13919633	88766796	102387480	36	11012											
FAM13A	10144	broad.mit.edu	37	chr4	89668975	89668975	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccgcatcctgggagttaggTcctcttcagatatctttagt	10	10	3	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr4:89668975T>C	uc003hse.1	-	18	2397	c.2189A>G	c.(2188-2190)GAC>GGC	p.D730G	FAM13A_uc003hsa.1_Missense_Mutation_p.D201G|FAM13A_uc003hsb.1_Missense_Mutation_p.D404G|FAM13A_uc003hsd.1_Missense_Mutation_p.D404G|FAM13A_uc003hsc.1_Missense_Mutation_p.D390G|FAM13A_uc011cdq.1_Missense_Mutation_p.D376G|FAM13A_uc003hsf.1_Missense_Mutation_p.D316G|FAM13A_uc003hsg.1_Missense_Mutation_p.D201G	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	730	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						GGGAGTTAGGTCCTCTTCAGA	0.348													C	89668975	C	C	89668975	3	2	156	1	0	0	0	0	1	0	0	0	5452	1667	58	4	910	4	FAM13A	4	89668975	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08	902179	89668975	101485301	37	11013											
CDH18	1016	broad.mit.edu	37	chr5	19747074	19747074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatctgacatttcaggcacaGtaacaatgtatggtccatct	7	9	3	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr5:19747074G>A	uc003jgc.2	-	3	877	c.500C>T	c.(499-501)ACT>ATT	p.T167I	CDH18_uc003jgd.2_Missense_Mutation_p.T167I|CDH18_uc011cnm.1_Missense_Mutation_p.T167I	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	167	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TTCAGGCACAGTAACAATGTA	0.338													A	19747074	A	A	19747074	3	1	156	1	0	0	0	0	1	0	0	0	3103	1029	36	3	1912	3	CDH18	5	19747074	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08		19747074	161168186	38	11014											
HEATR7B2	133558	broad.mit.edu	37	chr5	41012778	41012778	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggttgaggctctccagaccGtccagcatttcctctaggaa	11	12	2	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr5:41012778G>A	uc003jmj.3	-	30	3532	c.3042C>T	c.(3040-3042)GAC>GAT	p.D1014D	HEATR7B2_uc003jmi.3_Silent_p.D569D	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1014							binding			ovary(6)|central_nervous_system(2)	8						TCTCCAGACCGTCCAGCATTT	0.478													A	41012778	A	A	41012778	2	1	156	1	0	0	0	0	0	0	0	1	7035	1136	40	1		1	HEATR7B2	5	41012778	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	21265704	41012778	139902482	39	11015											
TTC37	9652	broad.mit.edu	37	chr5	94834176	94834176	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tctgataattactgtctttgTgtttgatgtgcttcagtaac	8	6	3	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr5:94834176T>A	uc003klb.2	-	33	3731	c.3461A>T	c.(3460-3462)CAC>CTC	p.H1154L		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1154							binding			ovary(3)|pancreas(1)	4						ACTGTCTTTGTGTTTGATGTG	0.448													A	94834176	A	A	94834176	3	1	156	1	0	0	0	0	1	0	0	0	16702	1696	59	5	1277	5	TTC37	5	94834176	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08	53821398	94834176	86081084	40	11016											
SPOCK1	6695	broad.mit.edu	37	chr5	136476318	136476318	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagggcggtctggtagtcctGggtcacacacactttgtgag	14	10	2	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr5:136476318G>A	uc003lbo.2	-	3	489	c.298C>T	c.(298-300)CAG>TAG	p.Q100*	SPOCK1_uc003lbp.2_Nonsense_Mutation_p.Q100*	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	100					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGGTAGTCCTGGGTCACACAC	0.617													A	136476318	A	A	136476318	4	1	156	1	0	0	0	0	0	1	0	0	15078	1357	47	3	1053	3	SPOCK1	5	136476318	Nonsense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	41642142	136476318	44438942	41	11017											
GTF2H4	2968	broad.mit.edu	37	chr6	30876944	30876944	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccctgccacatgtctggctgTcttcaggtgagaagcccctt	10	14	3	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr6:30876944T>G	uc003nsa.1	+	2	338	c.131T>G	c.(130-132)GTC>GGC	p.V44G	GTF2H4_uc010jsf.2_Missense_Mutation_p.V44G|GTF2H4_uc011dmv.1_Intron|GTF2H4_uc003nsb.1_5'UTR|GTF2H4_uc011dmw.1_Missense_Mutation_p.V50G	NM_001517	NP_001508	Q92759	TF2H4_HUMAN	general transcription factor IIH, polypeptide 4,	44					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3						TGTCTGGCTGTCTTCAGGTGA	0.527								NER					G	30876944	G	G	30876944	3	3	156	1	0	0	0	0	1	0	0	0	6865	1667	58	5	133	5	GTF2H4	6	30876944	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08		30876944	140238123	42	11018											
AARS2	57505	broad.mit.edu	37	chr6	44268962	44268962	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agtaggagcacagacgtgctGggggcctgctcacacagctg	15	11	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr6:44268962G>C	uc010jza.1	-	21	2727	c.2724C>G	c.(2722-2724)CCC>CCG	p.P908P	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	908					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			ovary(1)	1	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CAGACGTGCTGGGGGCCTGCT	0.647													C	44268962	C	C	44268962	2	2	156	1	0	0	0	0	0	0	0	1	20	1335	47	5		5	AARS2	6	44268962	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	13392018	44268962	126846105	43	11019											
LGSN	51557	broad.mit.edu	37	chr6	63991036	63991036	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atgtcgctattaaaacatgtGgctcttatgttattcatttc	6	7	2	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr6:63991036G>T	uc003peh.2	-	4	454	c.420C>A	c.(418-420)GCC>GCA	p.A140A	LGSN_uc003pei.2_Silent_p.A140A	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	140					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	TAAAACATGTGGCTCTTATGT	0.408													T	63991036	T	T	63991036	2	4	156	1	0	0	0	0	0	0	0	1	8759	1335	47	5		5	LGSN	6	63991036	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	19722074	63991036	107124031	44	11020											
SLC22A2	6582	broad.mit.edu	37	chr6	160679391	160679391	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttacctcggtgacgatggaCgagccaggcgtctcgtacac	12	13	1	1	rs112210325	byFrequency	TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr6:160679391C>T	uc003qtf.2	-	1	569	c.399G>A	c.(397-399)TCG>TCA	p.S133S	SLC22A2_uc003qte.1_Silent_p.S133S|SLC22A2_uc003qth.1_Silent_p.S133S	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	133	Extracellular (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		TGACGATGGACGAGCCAGGCG	0.627													T	160679391	T	T	160679391	2	4	156	1	0	0	0	0	0	0	0	1	14450	523	19	1		1	SLC22A2	6	160679391	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08	96688355	160679391	10435676	45	11021											
MAD1L1	8379	broad.mit.edu	37	chr7	2269722	2269722	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gagagatgaagttgttcaaaGatctcagggtggataaaacc	12	5	2	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr7:2269722G>A	uc003slh.1	-	3	313	c.47C>T	c.(46-48)TCT>TTT	p.S16F	MAD1L1_uc003slf.1_Missense_Mutation_p.S16F|MAD1L1_uc003slg.1_Missense_Mutation_p.S16F|MAD1L1_uc010ksh.1_Missense_Mutation_p.S16F|MAD1L1_uc003sli.1_Intron|MAD1L1_uc010ksi.1_Missense_Mutation_p.S16F|MAD1L1_uc010ksj.2_Missense_Mutation_p.S16F	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	16					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GTTGTTCAAAGATCTCAGGGT	0.537													A	2269722	A	A	2269722	3	1	156	1	0	0	0	0	1	0	0	0	9147	942	33	3	2177	3	MAD1L1	7	2269722	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08		2269722	156868941	46	11022											
SDK1	221935	broad.mit.edu	37	chr7	4009042	4009042	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccctgaatgcatcggccaCgctcactgtgtggagtaagg	12	12	1	1	rs145189416		TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr7:4009042C>T	uc003smx.2	+	11	1839	c.1700C>T	c.(1699-1701)ACG>ATG	p.T567M		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	567	Ig-like C2-type 5.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GCATCGGCCACGCTCACTGTG	0.587													T	4009042	T	T	4009042	3	4	156	1	0	0	0	0	1	0	0	0	13968	536	19	1	1742	1	SDK1	7	4009042	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	1739320	4009042	155129621	47	11023											
POM121L12	285877	broad.mit.edu	37	chr7	53103741	53103741	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgaaaggggggctgtgtcGtgcctggaacccaggacgga	17	9	0	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr7:53103741G>A	uc003tpz.2	+	1	393	c.377G>A	c.(376-378)CGT>CAT	p.R126H		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	126											0						GGGCTGTGTCGTGCCTGGAAC	0.672													A	53103741	A	A	53103741	3	1	156	1	0	0	0	0	1	0	0	0	12241	1145	40	1	379	1	POM121L12	7	53103741	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	49094699	53103741	106034922	48	11024											
DGKI	9162	broad.mit.edu	37	chr7	137363356	137363356	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagcagaggtctcccgagaCgttggtctccagccacaggt	13	12	2	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr7:137363356C>T	uc003vtt.2	-	3	554	c.553G>A	c.(553-555)GTC>ATC	p.V185I	DGKI_uc003vtu.2_5'UTR	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	185	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						TCTCCCGAGACGTTGGTCTCC	0.507													T	137363356	T	T	137363356	3	4	156	1	0	0	0	0	1	0	0	0	4471	536	19	1	2772	1	DGKI	7	137363356	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	84259615	137363356	21775307	49	11025											
HTR5A	3361	broad.mit.edu	37	chr7	154863096	154863096	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgtctccaacgtcatgatcGcgctcacctgggcactctcc	9	17	4	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr7:154863096G>A	uc003wlu.1	+	1	551	c.487G>A	c.(487-489)GCG>ACG	p.A163T	uc011kvt.1_5'UTR|uc003wlt.2_5'UTR	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	163	Helical; Name=4; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CGTCATGATCGCGCTCACCTG	0.627													A	154863096	A	A	154863096	3	1	156	1	0	0	0	0	1	0	0	0	7450	1087	38	1	489	1	HTR5A	7	154863096	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	17499740	154863096	4275567	50	11026											
EN2	2020	broad.mit.edu	37	chr7	155251752	155251752	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gcgctactcggaccggccttCttcaggtgagcccgcgggga	15	14	2	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr7:155251752C>T	uc003wmb.2	+	1	929	c.680C>T	c.(679-681)TCT>TTT	p.S227F		NM_001427	NP_001418	P19622	HME2_HUMAN	engrailed homeobox 2	227						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GACCGGCCTTCTTCAGGTGAG	0.726													T	155251752	T	T	155251752	3	4	156	1	0	0	0	0	1	0	0	0	5110	913	32	3	682	3	EN2	7	155251752	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	388656	155251752	3886911	51	11027											
LMBR1	64327	broad.mit.edu	37	chr7	156521400	156521400	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atttctttcccatgctgaagCcttttttcgcctctctatta	4	12	2	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr7:156521400C>G	uc003wmw.3	-	11	1068	c.853G>C	c.(853-855)GCT>CCT	p.A285P	LMBR1_uc003wmv.3_Missense_Mutation_p.A133P|LMBR1_uc003wmx.3_Missense_Mutation_p.A133P|LMBR1_uc010lqn.2_Missense_Mutation_p.A326P|LMBR1_uc011kvx.1_Missense_Mutation_p.A264P	NM_022458	NP_071903	Q8WVP7	LMBR1_HUMAN	limb region 1 protein	285	Potential.|Cytoplasmic (Potential).					integral to membrane	receptor activity				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		CATGCTGAAGCCTTTTTTCGC	0.299													G	156521400	G	G	156521400	3	3	156	1	0	0	0	0	1	0	0	0	8840	739	26	5	647	5	LMBR1	7	156521400	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	1269648	156521400	2617263	52	11028											
TUSC3	7991	broad.mit.edu	37	chr8	15508246	15508246	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatactggcgaactcctggCgctattcatctgctttttgt	8	10	2	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr8:15508246C>T	uc003wwt.2	+	3	559	c.349C>T	c.(349-351)CGC>TGC	p.R117C	TUSC3_uc003wwr.2_Missense_Mutation_p.R117C|TUSC3_uc003wws.2_Missense_Mutation_p.R117C|TUSC3_uc003wwu.2_Missense_Mutation_p.R117C|TUSC3_uc003wwv.2_Missense_Mutation_p.R117C|TUSC3_uc003www.2_Missense_Mutation_p.R117C|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.R117C	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	117					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		GAACTCCTGGCGCTATTCATC	0.398													T	15508246	T	T	15508246	3	4	156	1	0	0	0	0	1	0	0	0	16775	768	27	1	359	1	TUSC3	8	15508246	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08		15508246	130855776	53	11029											
MSR1	4481	broad.mit.edu	37	chr8	16021625	16021625	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agaatgttcccaatctttcaGtctgagatcattagtgatgt	8	7	4	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr8:16021625G>C	uc003wwz.2	-	5	964	c.766C>G	c.(766-768)CTG>GTG	p.L256V	MSR1_uc010lsu.2_Missense_Mutation_p.L274V|MSR1_uc003wxa.2_Missense_Mutation_p.L256V|MSR1_uc003wxb.2_Missense_Mutation_p.L256V|MSR1_uc011kxz.1_Missense_Mutation_p.L30V	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	256	Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CAATCTTTCAGTCTGAGATCA	0.308													C	16021625	C	C	16021625	3	2	156	1	0	0	0	0	1	0	0	0	9886	1020	36	5	661	5	MSR1	8	16021625	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	513379	16021625	130342397	54	11030											
EFCAB1	79645	broad.mit.edu	37	chr8	49643175	49643175	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccaatacatttacacagccAtcattatctttatcaaaacc	1	12	3	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr8:49643175A>G	uc003xqo.2	-	3	403	c.243T>C	c.(241-243)GAT>GAC	p.D81D	EFCAB1_uc003xqn.3_Intron|EFCAB1_uc011ldj.1_Silent_p.D29D|EFCAB1_uc010lxx.2_RNA|EFCAB1_uc011ldk.1_RNA	NM_024593	NP_078869	Q9HAE3	EFCB1_HUMAN	EF-hand calcium binding domain 1 isoform a	81	EF-hand 1.|1 (Potential).						calcium ion binding				0		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)				TTACACAGCCATCATTATCTT	0.368													G	49643175	G	G	49643175	2	3	156	1	0	0	0	0	0	0	0	1	4933	214	8	4		4	EFCAB1	8	49643175	Silent	SNP	A	TCGA-19-2623-01A-01D-1495-08	33621550	49643175	96720847	55	11031											
COLEC10	10584	broad.mit.edu	37	chr8	120118082	120118082	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaagagaaattctactacatCgtgcaggaagagaagaacta	10	6	1	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr8:120118082C>T	uc003yoo.2	+	6	583	c.486C>T	c.(484-486)ATC>ATT	p.I162I		NM_006438	NP_006429	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 precursor	162	C-type lectin.					collagen|cytoplasm	mannose binding			ovary(2)|skin(1)	3	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			TCTACTACATCGTGCAGGAAG	0.458													T	120118082	T	T	120118082	2	4	156	1	0	0	0	0	0	0	0	1	3710	874	31	2		2	COLEC10	8	120118082	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08	70474907	120118082	26245940	56	11032											
CYP11B1	1584	broad.mit.edu	37	chr8	143956451	143956451	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgccaaagccaaagggcacGtggtagaagttcctgccgga	13	10	0	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr8:143956451G>A	uc003yxi.2	-	8	1327	c.1320C>T	c.(1318-1320)CAC>CAT	p.H440H	CYP11B1_uc010mex.2_Silent_p.H139H|CYP11B1_uc003yxh.2_Intron|CYP11B1_uc003yxj.2_Intron|CYP11B1_uc010mey.2_Silent_p.H511H	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	440					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CAAAGGGCACGTGGTAGAAGT	0.652									Familial_Hyperaldosteronism_type_I				A	143956451	A	A	143956451	2	1	156	1	0	0	0	0	0	0	0	1	4145	1136	40	1		1	CYP11B1	8	143956451	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	23838369	143956451	2407571	57	11033											
TAF1L	138474	broad.mit.edu	37	chr9	32633905	32633905	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctgttttgcccaagagaattCgactcttcttcagagatgat	8	9	3	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr9:32633905C>A	uc003zrg.1	-	1	1763	c.1673G>T	c.(1672-1674)CGA>CTA	p.R558L	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	558					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CAAGAGAATTCGACTCTTCTT	0.458													A	32633905	A	A	32633905	3	1	156	1	0	0	0	0	1	0	0	0	15520	884	31	5	3811	5	TAF1L	9	32633905	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08		32633905	108579526	58	11034											
NOL6	65083	broad.mit.edu	37	chr9	33465223	33465223	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acctcggaggggtgaagggcTcagggtgcaggaaaagggca	19	7	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr9:33465223T>C	uc003zsz.2	-	20	2764	c.2663A>G	c.(2662-2664)GAG>GGG	p.E888G	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Intron|NOL6_uc010mjv.2_Missense_Mutation_p.E885G|NOL6_uc011lob.1_Missense_Mutation_p.E836G|NOL6_uc003ztb.1_Missense_Mutation_p.E888G	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	888					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GGTGAAGGGCTCAGGGTGCAG	0.602													C	33465223	C	C	33465223	3	2	156	1	0	0	0	0	1	0	0	0	10525	1551	54	4	805	4	NOL6	9	33465223	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08	831318	33465223	107748208	59	11035											
TRPM3	80036	broad.mit.edu	37	chr9	73167906	73167906	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtcatgatgagctgatacCtctgaaacttccagacttgg	9	9	2	5			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr9:73167906C>T	uc004aid.2	-	23	3636	c.3392G>A	c.(3391-3393)AGG>AAG	p.R1131K	TRPM3_uc004ahu.2_Missense_Mutation_p.R973K|TRPM3_uc004ahv.2_Missense_Mutation_p.R933K|TRPM3_uc004ahw.2_Missense_Mutation_p.R1003K|TRPM3_uc004ahx.2_Missense_Mutation_p.R990K|TRPM3_uc004ahy.2_Missense_Mutation_p.R993K|TRPM3_uc004ahz.2_Missense_Mutation_p.R980K|TRPM3_uc004aia.2_Missense_Mutation_p.R978K|TRPM3_uc004aib.2_Missense_Mutation_p.R968K|TRPM3_uc004aic.2_Missense_Mutation_p.R1131K	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1156	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						GAGCTGATACCTCTGAAACTT	0.423													T	73167906	T	T	73167906	3	4	156	1	0	0	0	0	1	0	0	0	16584	681	24	3	1743	3	TRPM3	9	73167906	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	39702683	73167906	68045525	60	11036											
IKBKAP	8518	broad.mit.edu	37	chr9	111658909	111658909	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagcactcacagcatcaggaTcagagggagcatttcctaac	9	12	3	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr9:111658909T>A	uc004bdm.3	-	25	3123	c.2603A>T	c.(2602-2604)GAT>GTT	p.D868V	IKBKAP_uc004bdl.2_Missense_Mutation_p.D519V|IKBKAP_uc011lwc.1_Missense_Mutation_p.D754V|IKBKAP_uc010mtq.2_Missense_Mutation_p.D519V	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	868					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						AGCATCAGGATCAGAGGGAGC	0.368													A	111658909	A	A	111658909	3	1	156	1	0	0	0	0	1	0	0	0	7610	1435	50	5	1447	5	IKBKAP	9	111658909	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08	38491003	111658909	29554522	61	11037											
SPTAN1	6709	broad.mit.edu	37	chr9	131371470	131371470	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaatctcaaaccctccaacaGttcagccgggatgtggatga	10	11	2	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr9:131371470G>C	uc004bvl.3	+	36	4778	c.4665G>C	c.(4663-4665)CAG>CAC	p.Q1555H	SPTAN1_uc004bvm.3_Missense_Mutation_p.Q1555H|SPTAN1_uc004bvn.3_Missense_Mutation_p.Q1535H	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1555	Spectrin 17.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CCCTCCAACAGTTCAGCCGGG	0.473													C	131371470	C	C	131371470	3	2	156	1	0	0	0	0	1	0	0	0	15116	1020	36	5	4803	5	SPTAN1	9	131371470	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	19712561	131371470	9841961	62	11038											
LHX3	8022	broad.mit.edu	37	chr9	139092592	139092592	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtcacagccagcgcacagCgggatctctgtgggcacgag	15	12	2	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr9:139092592C>T	uc004cha.2	-	2	184	c.87G>A	c.(85-87)CCG>CCA	p.P29P	LHX3_uc004cgz.2_Silent_p.P34P	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	29					inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		CAGCGCACAGCGGGATCTCTG	0.632													T	139092592	T	T	139092592	2	4	156	1	0	0	0	0	0	0	0	1	8772	755	27	1		1	LHX3	9	139092592	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08	7721122	139092592	2120839	63	11039											
OR4P4	81300	broad.mit.edu	37	chr11	55406513	55406513	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtataccatcagagcatactCtgcagagagacgcagcaaag	10	10	2	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr11:55406513C>T	uc010rij.1	+	1	680	c.680C>T	c.(679-681)TCT>TTT	p.S227F		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AGAGCATACTCTGCAGAGAGA	0.393													T	55406513	T	T	55406513	3	4	156	1	0	0	0	0	1	0	0	0	11080	913	32	3	682	3	OR4P4	11	55406513	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08		55406513	79600003	64	11040											
OR5D16	390144	broad.mit.edu	37	chr11	55606713	55606713	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatgttccctgacactcgcGtgctctgctttaaagttatc	8	12	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr11:55606713G>A	uc010rio.1	+	1	486	c.486G>A	c.(484-486)GCG>GCA	p.A162A		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	162	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TGACACTCGCGTGCTCTGCTT	0.453													A	55606713	A	A	55606713	2	1	156	1	0	0	0	0	0	0	0	1	11156	1132	40	1		1	OR5D16	11	55606713	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	200200	55606713	79399803	65	11041											
PVRL1	5818	broad.mit.edu	37	chr11	119535607	119535607	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcggcctcatccacggtgaaGtagggccgcttggcgtcctc	13	14	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr11:119535607G>C	uc001pwv.2	-	6	1576	c.1404C>G	c.(1402-1404)TAC>TAG	p.Y468*	PVRL1_uc001pwu.1_Intron	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	468	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CCACGGTGAAGTAGGGCCGCT	0.582													C	119535607	C	C	119535607	4	2	156	1	0	0	0	0	0	1	0	0	12839	1024	36	5	539	5	PVRL1	11	119535607	Nonsense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	63928894	119535607	15470909	66	11042											
LEPREL2	10536	broad.mit.edu	37	chr12	6939135	6939135	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagacgaatgtcgggagttcGgccccagagcttccgggacc	14	13	0	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr12:6939135G>A	uc001qra.1	+	4	645	c.611G>A	c.(610-612)CGG>CAG	p.R204Q	LEPREL2_uc001qqz.1_Missense_Mutation_p.R11Q|LEPREL2_uc001qrb.1_Missense_Mutation_p.R11Q|GPR162_uc001qqy.1_Missense_Mutation_p.R139Q	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	204					negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCGGGAGTTCGGCCCCAGAGC	0.602													A	6939135	A	A	6939135	3	1	156	1	0	0	0	0	1	0	0	0	8731	1116	39	2	616	2	LEPREL2	12	6939135	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08		6939135	126912760	67	11043											
C12orf39	80763	broad.mit.edu	37	chr12	21681996	21681996	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcaaccatcttactggcGtcccttcagaaatcaccaga	7	14	3	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr12:21681996G>A	uc001rfa.1	+	5	421	c.270G>A	c.(268-270)GCG>GCA	p.A90A	C12orf39_uc009ziv.1_RNA|C12orf39_uc009ziw.1_RNA	NM_030572	NP_085049	Q9BT56	SPXN_HUMAN	spexin precursor	90						extracellular region|nucleus|transport vesicle					0						TCTTACTGGCGTCCCTTCAGA	0.438													A	21681996	A	A	21681996	2	1	156	1	0	0	0	0	0	0	0	1	1684	1132	40	1		1	C12orf39	12	21681996	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	14742861	21681996	112169899	68	11044											
ITPR2	3709	broad.mit.edu	37	chr12	26628304	26628304	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctccaccctcatcatccccAtggtcacattccaatccttg	3	18	4	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr12:26628304A>G	uc001rhg.2	-	45	6684	c.6267T>C	c.(6265-6267)CAT>CAC	p.H2089H	ITPR2_uc009zjg.1_Silent_p.H240H	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2089	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CATCATCCCCATGGTCACATT	0.368													G	26628304	G	G	26628304	2	3	156	1	0	0	0	0	0	0	0	1	7921	214	8	4		4	ITPR2	12	26628304	Silent	SNP	A	TCGA-19-2623-01A-01D-1495-08	4946308	26628304	107223591	69	11045											
SFRS2IP	9169	broad.mit.edu	37	chr12	46321868	46321868	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gatgaactgtacatacatctGtctttacctctgattgtgaa	7	8	3	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr12:46321868G>C	uc001rox.2	-	11	1903	c.1616C>G	c.(1615-1617)ACA>AGA	p.T539R	SFRS2IP_uc001row.2_Missense_Mutation_p.T224R|SFRS2IP_uc001roy.1_Missense_Mutation_p.T613R	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	539					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		ACATACATCTGTCTTTACCTC	0.363													C	46321868	C	C	46321868	3	2	156	1	0	0	0	0	1	0	0	0	14177	1377	48	5	2795	5	SFRS2IP	12	46321868	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	19693564	46321868	87530027	70	11046											
SPATS2	65244	broad.mit.edu	37	chr12	49919998	49919998	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaaaggggctcccccagcGcaaacccaggacctctcaga	9	16	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr12:49919998G>A	uc001rud.2	+	14	2587	c.1598G>A	c.(1597-1599)CGC>CAC	p.R533H	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Missense_Mutation_p.R533H|SPATS2_uc001ruf.2_Missense_Mutation_p.R533H|SPATS2_uc001rug.2_Missense_Mutation_p.R533H	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	533						cytoplasm		p.R533H(1)		breast(1)	1						CTCCCCCAGCGCAAACCCAGG	0.522													A	49919998	A	A	49919998	3	1	156	1	0	0	0	0	1	0	0	0	15018	1087	38	1	1644	1	SPATS2	12	49919998	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	3598130	49919998	83931897	71	11047											
MGAT4C	25834	broad.mit.edu	37	chr12	86373320	86373324	+	Frame_Shift_Del	DEL	TTTAC	-	-													gccgatcttctgttccagtaTttactttaattttttttatt							TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr12:86373320_86373324delTTTAC	uc001tai.3	-	8	2430_2434	c.1180_1184delGTAAA	c.(1180-1185)GTAAATfs	p.V394fs	MGAT4C_uc001tal.3_Frame_Shift_Del_p.V394fs|MGAT4C_uc001taj.3_Frame_Shift_Del_p.V394fs|MGAT4C_uc001tak.3_Frame_Shift_Del_p.V394fs|MGAT4C_uc010sum.1_Frame_Shift_Del_p.V418fs|MGAT4C_uc001tah.3_Frame_Shift_Del_p.V394fs	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	394_395	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TGTTCCAGTATTTACtttaattttt	0.346													-	86373324	-	-	86373320	7	5	156	1	0	1	0	1	0	0	0	0	9547	1493	52	0	256	0	MGAT4C	12	86373320	Frame_Shift_Del	DEL	TTTAC	TCGA-19-2623-01A-01D-1495-08	36453322	86373320	47478575	72	11048											
RFX4	5992	broad.mit.edu	37	chr12	107033171	107033172	+	Splice_Site	INS	-	T	T													ctcctgctactctgcaatggINStaagtttccatttttagcaa							TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr12:107033171_107033172insT	uc001tlr.2	+	3	257	c.191_splice	c.e3+1	p.W64_splice	RFX4_uc010swv.1_Splice_Site|RFX4_uc001tls.2_Splice_Site_p.W73_splice|RFX4_uc001tlt.2_Splice_Site_p.W73_splice	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c						transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						CTCTGCAATGGTAAGTTTCCAT	0.371													T	107033172	T	T	107033171	8	5	156	1	0	1	1	0	0	0	1	0	13265	1275	44	0	276	0	RFX4	12	107033171	Splice_Site	INS	-	TCGA-19-2623-01A-01D-1495-08	20659851	107033171	26818724	73	11049											
FLT3	2322	broad.mit.edu	37	chr13	28592630	28592630	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cctgacaacatagttggaatCactcatgatatctcgagcca	7	11	3	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr13:28592630C>G	uc001urw.2	-	20	2597	c.2515G>C	c.(2515-2517)GAT>CAT	p.D839H	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Intron	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	839	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.D839?(2)		haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TAGTTGGAATCACTCATGATA	0.453			Mis|O		AML|ALL								G	28592630	G	G	28592630	3	3	156	1	0	0	0	0	1	0	0	0	5942	826	29	5	486	5	FLT3	13	28592630	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08		28592630	86577248	74	11050											
RB1	5925	broad.mit.edu	37	chr13	48955560	48955563	+	Frame_Shift_Del	DEL	AATC	-	-													atgtgaacatcgaatcatggAatcccttgcatggctctcag							TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr13:48955560_48955563delAATC	uc001vcb.2	+	17	1842_1845	c.1676_1679delAATC	c.(1675-1680)GAATCCfs	p.E559fs		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	559_560	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGAATCATGGAATCCCTTGCATGG	0.328		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			-	48955563	-	-	48955560	7	5	156	1	0	1	0	1	0	0	0	0	13098	246	9	0	1742	0	RB1	13	48955560	Frame_Shift_Del	DEL	AATC	TCGA-19-2623-01A-01D-1495-08	20362930	48955560	66214318	75	11051											
PSMA3	5684	broad.mit.edu	37	chr14	58737688	58737688	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaaattgttccaaaagataTaagagaagaagcagagaaat	9	3	0	5			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr14:58737688T>C	uc001xdj.1	+	10	741	c.695T>C	c.(694-696)ATA>ACA	p.I232T	C14orf37_uc010tro.1_Intron|PSMA3_uc001xdk.1_Missense_Mutation_p.I225T|uc001xdl.2_Intron	NM_002788	NP_002779	P25788	PSA3_HUMAN	proteasome alpha 3 subunit isoform 1	232					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity				0						CCAAAAGATATAAGAGAAGAA	0.289													C	58737688	C	C	58737688	3	2	156	1	0	0	0	0	1	0	0	0	12668	1406	49	4	733	4	PSMA3	14	58737688	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08		58737688	48611852	76	11052											
CDCA4	55038	broad.mit.edu	37	chr14	105477700	105477700	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcagtactgtgtccaggtcGtagtaggggctgtccacgtc	14	10	1	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr14:105477700G>A	uc001yqa.2	-	2	663	c.567C>T	c.(565-567)TAC>TAT	p.Y189Y	CDCA4_uc001yqb.2_Silent_p.Y189Y	NM_145701	NP_663747	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	189						nucleus				ovary(1)	1		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		TGTCCAGGTCGTAGTAGGGGC	0.587													A	105477700	A	A	105477700	2	1	156	1	0	0	0	0	0	0	0	1	3088	1140	40	1		1	CDCA4	14	105477700	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	46740012	105477700	1871840	77	11053											
MKRN3	7681	broad.mit.edu	37	chr15	23812072	23812072	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagttctgggtggaggaggaGgaagagaagcagaaacttat	17	3	1	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr15:23812072G>A	uc001ywh.3	+	1	1619	c.1143G>A	c.(1141-1143)GAG>GAA	p.E381E	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Silent_p.E381E	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	381						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TGGAGGAGGAGGAAGAGAAGC	0.507													A	23812072	A	A	23812072	2	1	156	1	0	0	0	0	0	0	0	1	9608	991	35	3		3	MKRN3	15	23812072	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08		23812072	78719320	78	11054											
FMN1	342184	broad.mit.edu	37	chr15	33358855	33358855	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcccctttctggggggccGgatgaatagggctttaaaag	15	8	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr15:33358855G>A	uc001zhf.3	-	1	1231	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	FMN1_uc001zhg.2_Missense_Mutation_p.R411W	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CTGGGGGGCCGGATGAATAGG	0.567													A	33358855	A	A	33358855	3	1	156	1	0	0	0	0	1	0	0	0	5949	1115	39	2	2427	2	FMN1	15	33358855	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	9546783	33358855	69172537	79	11055											
GPR176	11245	broad.mit.edu	37	chr15	40093624	40093624	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaggggtggggcagagggCgcaaactgtggcccctgctc	17	12	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr15:40093624C>T	uc001zkj.1	-	3	2123	c.1257G>A	c.(1255-1257)GCG>GCA	p.A419A	GPR176_uc010uck.1_Silent_p.A359A	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	419	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		GGGCAGAGGGCGCAAACTGTG	0.572													T	40093624	T	T	40093624	2	4	156	1	0	0	0	0	0	0	0	1	6673	755	27	1		1	GPR176	15	40093624	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08	6734769	40093624	62437768	80	11056											
PLA2G4D	283748	broad.mit.edu	37	chr15	42364007	42364007	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tccggggctccgggatcctcCtcatcagccgtcccatgaag	11	16	2	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr15:42364007C>A	uc001zox.2	-	15	1633	c.1538G>T	c.(1537-1539)AGG>ATG	p.R513M		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	513	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		CGGGATCCTCCTCATCAGCCG	0.617													A	42364007	A	A	42364007	3	1	156	1	0	0	0	0	1	0	0	0	12004	681	24	5	942	5	PLA2G4D	15	42364007	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	2270383	42364007	60167385	81	11057											
C15orf48	84419	broad.mit.edu	37	chr15	45724277	45724277	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tctttaattttagccttgatCgaaaaaaaaatccagaacct	4	8	1	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr15:45724277C>T	uc001zvg.2	+	4	248	c.130C>T	c.(130-132)CGA>TGA	p.R44*	C15orf48_uc001zvh.2_Nonsense_Mutation_p.R44*|MIR147B_hsa-mir-147b|MI0005544_5'Flank	NM_197955	NP_922946	Q9C002	NMES1_HUMAN	normal mucosa of esophagus specific 1	44						nucleus				ovary(1)	1		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.67e-16)|GBM - Glioblastoma multiforme(94;1.71e-06)		TAGCCTTGATCGAAAAAAAAA	0.313													T	45724277	T	T	45724277	4	4	156	1	0	0	0	0	0	1	0	0	1799	876	31	2	140	2	C15orf48	15	45724277	Nonsense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	3360270	45724277	56807115	82	11058											
UACA	55075	broad.mit.edu	37	chr15	70970467	70970467	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtaactgtaaaccattgaCtttatccaaaagtattcttt	4	8	1	1	rs145715387		TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr15:70970467C>T	uc002asr.2	-	11	1074	c.970G>A	c.(970-972)GTC>ATC	p.V324I	UACA_uc010uke.1_Missense_Mutation_p.V215I|UACA_uc002asq.2_Missense_Mutation_p.V311I|UACA_uc010bin.1_Missense_Mutation_p.V310I	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	324	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						AAACCATTGACTTTATCCAAA	0.284													T	70970467	T	T	70970467	3	4	156	1	0	0	0	0	1	0	0	0	16821	565	20	3	3316	3	UACA	15	70970467	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	25246190	70970467	31560925	83	11059											
MYH11	4629	broad.mit.edu	37	chr16	15857677	15857677	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttatctggcatggacgcctGgtctgtgtttctttccttct	10	10	4	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr16:15857677G>A	uc002ddy.2	-	10	1212	c.1105C>T	c.(1105-1107)CAG>TAG	p.Q369*	MYH11_uc002ddv.2_Nonsense_Mutation_p.Q376*|MYH11_uc002ddw.2_Nonsense_Mutation_p.Q369*|MYH11_uc002ddx.2_Nonsense_Mutation_p.Q376*|MYH11_uc010bvg.2_Nonsense_Mutation_p.Q201*|MYH11_uc002dea.1_Nonsense_Mutation_p.Q75*	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	369	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						ATGGACGCCTGGTCTGTGTTT	0.507			T	CBFB	AML								A	15857677	A	A	15857677	4	1	156	1	0	0	0	0	0	1	0	0	10031	1357	47	3	4976	3	MYH11	16	15857677	Nonsense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08		15857677	74497076	84	11060											
DNAH3	55567	broad.mit.edu	37	chr16	21145656	21145656	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctcgttccacttcttggCgctcctgtagacactgtgcc	8	16	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr16:21145656C>T	uc010vbe.1	-	7	1006	c.1006G>A	c.(1006-1008)GCC>ACC	p.A336T	DNAH3_uc002die.2_Missense_Mutation_p.A307T	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	336	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CACTTCTTGGCGCTCCTGTAG	0.527													T	21145656	T	T	21145656	3	4	156	1	0	0	0	0	1	0	0	0	4603	768	27	1	11567	1	DNAH3	16	21145656	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	5287979	21145656	69209097	85	11061											
ITGAD	3681	broad.mit.edu	37	chr16	31426282	31426282	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacctgcgtcctgtgctggcCgtgggctcacaagacctctt	11	14	2	1	rs144306080	byFrequency	TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr16:31426282C>T	uc002ebv.1	+	18	2302	c.2253C>T	c.(2251-2253)GCC>GCT	p.A751A	ITGAD_uc010cap.1_Silent_p.A752A	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	751	Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CTGTGCTGGCCGTGGGCTCAC	0.537													T	31426282	T	T	31426282	2	4	156	1	0	0	0	0	0	0	0	1	7884	639	23	2		2	ITGAD	16	31426282	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08	10280626	31426282	58928471	86	11062											
CYLD	1540	broad.mit.edu	37	chr16	50815179	50815179	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatgagtgtgcaggctgtaCggatggaaccttcagaggca	15	7	1	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr16:50815179C>T	uc002egp.1	+	10	1956	c.1541C>T	c.(1540-1542)ACG>ATG	p.T514M	CYLD_uc002ego.2_Missense_Mutation_p.T511M|CYLD_uc010cbs.1_Missense_Mutation_p.T511M|CYLD_uc002egq.1_Missense_Mutation_p.T511M|CYLD_uc002egr.1_Missense_Mutation_p.T511M|CYLD_uc002egs.1_Missense_Mutation_p.T511M	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	514	CAP-Gly 3.|Interaction with TRIP.|Interaction with IKBKG/NEMO.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding	p.T514fs*29(1)		skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				GCAGGCTGTACGGATGGAACC	0.453			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				T	50815179	T	T	50815179	3	4	156	1	0	0	0	0	1	0	0	0	4143	536	19	1	1571	1	CYLD	16	50815179	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	19388897	50815179	39539574	87	11063											
LRRC50	123872	broad.mit.edu	37	chr16	84203580	84203580	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagctatttgttaaggaaagCtttgaggccaaggacgagct	13	6	0	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr16:84203580C>A	uc002fhl.3	+	8	1327	c.1146C>A	c.(1144-1146)AGC>AGA	p.S382R	LRRC50_uc010vnw.1_Missense_Mutation_p.S146R	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	382					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						TTAAGGAAAGCTTTGAGGCCA	0.577									Kartagener_syndrome				A	84203580	A	A	84203580	3	1	156	1	0	0	0	0	1	0	0	0	9009	796	28	5	1176	5	LRRC50	16	84203580	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	33388401	84203580	6151173	88	11064											
NLRP1	22861	broad.mit.edu	37	chr17	5463322	5463322	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccaccgctgcccatggggGcctgcctttctctgatttct	9	15	2	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr17:5463322G>A	uc002gci.2	-	4	1249	c.694C>T	c.(694-696)CCC>TCC	p.P232S	NLRP1_uc002gcg.1_Missense_Mutation_p.P232S|NLRP1_uc002gck.2_Missense_Mutation_p.P232S|NLRP1_uc002gcj.2_Missense_Mutation_p.P232S|NLRP1_uc002gcl.2_Missense_Mutation_p.P232S|NLRP1_uc002gch.3_Missense_Mutation_p.P232S|NLRP1_uc010clh.2_Missense_Mutation_p.P232S	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	232					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GCCCATGGGGGCCTGCCTTTC	0.507													A	5463322	A	A	5463322	3	1	156	1	0	0	0	0	1	0	0	0	10471	1203	42	3	3858	3	NLRP1	17	5463322	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08		5463322	75731888	89	11065											
TP53	7157	broad.mit.edu	37	chr17	7577548	7577548	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgggcctccggttcatgcCgcccatgcaggaactgttac	12	13	1	0	rs28934575		TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577548	T	T	7577548	3	4	156	1	0	0	0	0	1	0	0	0	16378	652	23	2	557	2	TP53	17	7577548	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	2114226	7577548	73617662	90	11066											
MYH8	4626	broad.mit.edu	37	chr17	10297588	10297588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtgtggaggagctggacaCgctcactggcatccaggagc	17	10	1	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr17:10297588C>T	uc002gmm.2	-	35	5239	c.5144G>A	c.(5143-5145)CGT>CAT	p.R1715H	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1715	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GAGCTGGACACGCTCACTGGC	0.512									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				T	10297588	T	T	10297588	3	4	156	1	0	0	0	0	1	0	0	0	10041	536	19	1	693	1	MYH8	17	10297588	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	2720040	10297588	70897622	91	11067											
CCL13	6357	broad.mit.edu	37	chr17	32685057	32685057	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctccacagcttcagaaccaaActgggcaaggagatctgtgc	10	12	2	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr17:32685057A>C	uc002hic.2	+	3	279	c.204A>C	c.(202-204)AAA>AAC	p.K68N		NM_005408	NP_005399	Q99616	CCL13_HUMAN	small inducible cytokine A13 precursor	68					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response	extracellular space	chemokine activity|signal transducer activity				0		Ovarian(249;0.0443)|Breast(31;0.151)				TCAGAACCAAACTGGGCAAGG	0.512													C	32685057	C	C	32685057	3	2	156	1	0	0	0	0	1	0	0	0	2884	40	2	5	214	5	CCL13	17	32685057	Missense_Mutation	SNP	A	TCGA-19-2623-01A-01D-1495-08	22387469	32685057	48510153	92	11068											
KRT25	147183	broad.mit.edu	37	chr17	38911514	38911514	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctggatgcactggaaagtcGaagagacatggtatcagggc	14	8	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr17:38911514G>A	uc002hve.2	-	1	71	c.10C>T	c.(10-12)CGA>TGA	p.R4*		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	4	Head.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				CTGGAAAGTCGAAGAGACATG	0.488													A	38911514	A	A	38911514	4	1	156	1	0	0	0	0	0	1	0	0	8462	1066	37	2	1374	2	KRT25	17	38911514	Nonsense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	6226457	38911514	42283696	93	11069											
DHX8	1659	broad.mit.edu	37	chr17	41601142	41601142	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaacagaagaagcaacagcGtcttgaacccttgtacaacc	7	12	1	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr17:41601142G>A	uc002idu.1	+	23	3663	c.3590G>A	c.(3589-3591)CGT>CAT	p.R1197H	DHX8_uc010wig.1_Intron	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	1197						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		AAGCAACAGCGTCTTGAACCC	0.517													A	41601142	A	A	41601142	3	1	156	1	0	0	0	0	1	0	0	0	4515	1145	40	1	3680	1	DHX8	17	41601142	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	2689628	41601142	39594068	94	11070											
TBX21	30009	broad.mit.edu	37	chr17	45822386	45822386	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcccaccatgtcctactaccGaggccaggaggtcctggcac	11	16	0	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr17:45822386G>A	uc002ilv.1	+	6	1473	c.1262G>A	c.(1261-1263)CGA>CAA	p.R421Q		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	421					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						TCCTACTACCGAGGCCAGGAG	0.662													A	45822386	A	A	45822386	3	1	156	1	0	0	0	0	1	0	0	0	15654	1058	37	2	1284	2	TBX21	17	45822386	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	4221244	45822386	35372824	95	11071											
MC2R	4158	broad.mit.edu	37	chr18	13885081	13885081	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgtaagcaccaccacagtgCggcgcatggtcacgatgctg	12	14	1	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr18:13885081C>T	uc002ksp.1	-	2	614	c.437G>A	c.(436-438)CGC>CAC	p.R146H		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	146	Cytoplasmic (By similarity).		R -> H (in GCCD1).		G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	CACCACAGTGCGGCGCATGGT	0.577													T	13885081	T	T	13885081	3	4	156	1	0	0	0	0	1	0	0	0	9364	768	27	1	460	1	MC2R	18	13885081	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08		13885081	64192167	96	11072											
ATP5A1	498	broad.mit.edu	37	chr18	43668121	43668121	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgggcaacagtggatctcttTtgaccaatagcaacataaat	8	8	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr18:43668121T>C	uc002lbr.1	-	6	843	c.753A>G	c.(751-753)CAA>CAG	p.Q251Q	ATP5A1_uc010dnl.1_Silent_p.Q201Q|ATP5A1_uc002lbs.1_Silent_p.Q201Q|ATP5A1_uc002lbt.1_Silent_p.Q251Q	NM_004046	NP_004037	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	251					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0						TGGATCTCTTTTGACCAATAG	0.368													C	43668121	C	C	43668121	2	2	156	1	0	0	0	0	0	0	0	1	1147	1838	64	4		4	ATP5A1	18	43668121	Silent	SNP	T	TCGA-19-2623-01A-01D-1495-08	29783040	43668121	34409127	97	11073											
INSR	3643	broad.mit.edu	37	chr19	7117197	7117197	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accctccatcccggccccccGcctcctccctctgacagtgc	6	24	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr19:7117197G>A	uc002mgd.1	-	22	4128	c.4019C>T	c.(4018-4020)GCG>GTG	p.A1340V	INSR_uc002mge.1_Missense_Mutation_p.A1328V	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1340	Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCGGCCCCCCGCCTCCTCCCT	0.592													A	7117197	A	A	7117197	3	1	156	1	0	0	0	0	1	0	0	0	7773	1087	38	1	133	1	INSR	19	7117197	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08		7117197	52011786	98	11074											
FBN3	84467	broad.mit.edu	37	chr19	8160957	8160957	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaggctgccggtcacactcGtcaatgtctgcagaagcaaa	10	12	3	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr19:8160957G>A	uc002mjf.2	-	44	5568	c.5547C>T	c.(5545-5547)GAC>GAT	p.D1849D		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1849	EGF-like 29; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGTCACACTCGTCAATGTCTG	0.582													A	8160957	A	A	8160957	2	1	156	1	0	0	0	0	0	0	0	1	5704	1136	40	1		1	FBN3	19	8160957	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	1043760	8160957	50968026	99	11075											
OR7C1	26664	broad.mit.edu	37	chr19	14910414	14910414	+	Frame_Shift_Del	DEL	A	-	-													caggacttcaagtagatcacAaaaaaagtgtggaatttcca							TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr19:14910414delA	uc010xnz.1	-	1	535	c.535delT	c.(535-537)TGTfs	p.C179fs		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	179	Extracellular (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						AGTAGATCACAAAAAAAGTGT	0.478													-	14910414	-	-	14910414	7	5	156	1	0	1	0	1	0	0	0	0	11217	130	5	0	429	0	OR7C1	19	14910414	Frame_Shift_Del	DEL	A	TCGA-19-2623-01A-01D-1495-08	6749457	14910414	44218569	100	11076											
UPF1	5976	broad.mit.edu	37	chr19	18976409	18976409	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagactggtcgtgggggacGccagaagaaccgctttgggc	16	10	0	3	rs139317612		TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr19:18976409G>A	uc002nkg.2	+	22	3367	c.3092G>A	c.(3091-3093)CGC>CAC	p.R1031H	UPF1_uc002nkf.2_Missense_Mutation_p.R1020H|UPF1_uc002nkh.2_Missense_Mutation_p.R275H	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	1031					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CGTGGGGGACGCCAGAAGAAC	0.642													A	18976409	A	A	18976409	3	1	156	1	0	0	0	0	1	0	0	0	17000	1087	38	1	3145	1	UPF1	19	18976409	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	4065995	18976409	40152574	101	11077											
PLEKHG2	64857	broad.mit.edu	37	chr19	39908257	39908257	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgcgagatggtggaggaagcTattgtgtccatgacagcggt	16	7	0	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr19:39908257T>C	uc010xuz.1	+	8	1132	c.807T>C	c.(805-807)GCT>GCC	p.A269A	PLEKHG2_uc010xuy.1_Silent_p.A210A|PLEKHG2_uc002olj.2_Silent_p.A269A|PLEKHG2_uc010xva.1_Silent_p.A76A	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	269	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGGAGGAAGCTATTGTGTCCA	0.602													C	39908257	C	C	39908257	2	2	156	1	0	0	0	0	0	0	0	1	12069	1509	53	4		4	PLEKHG2	19	39908257	Silent	SNP	T	TCGA-19-2623-01A-01D-1495-08	20931848	39908257	19220726	102	11078											
XRCC1	7515	broad.mit.edu	37	chr19	44057610	44057610	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccggcctcagagagttggCgctctcatcctcctccttca	8	18	3	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr19:44057610C>T	uc002owt.2	-	6	664	c.544G>A	c.(544-546)GCC>ACC	p.A182T	XRCC1_uc010xwp.1_Missense_Mutation_p.A151T	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	182					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				AGAGAGTTGGCGCTCTCATCC	0.502								Other_BER_factors					T	44057610	T	T	44057610	3	4	156	1	0	0	0	0	1	0	0	0	17449	768	27	1	1405	1	XRCC1	19	44057610	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	4149353	44057610	15071373	103	11079											
NLRP2	55655	broad.mit.edu	37	chr19	55501996	55501996	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aatacaggggtgaagtttctGtgtgagggcttgaggtaccc	15	6	1	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr19:55501996G>C	uc002qij.2	+	10	2750	c.2664G>C	c.(2662-2664)CTG>CTC	p.L888L	NLRP2_uc010yfp.1_Silent_p.L865L|NLRP2_uc010esn.2_Silent_p.L864L|NLRP2_uc010eso.2_Silent_p.L885L|NLRP2_uc010esp.2_Silent_p.L866L	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	888	LRR 3.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TGAAGTTTCTGTGTGAGGGCT	0.567													C	55501996	C	C	55501996	2	2	156	1	0	0	0	0	0	0	0	1	10477	1364	48	5		5	NLRP2	19	55501996	Silent	SNP	G	TCGA-19-2623-01A-01D-1495-08	11444386	55501996	3626987	104	11080											
NLRP5	126206	broad.mit.edu	37	chr19	56539073	56539073	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtggtgggggagagcgtcGcccccttcaaccaaacgctc	13	14	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr19:56539073G>A	uc002qmj.2	+	7	1474	c.1474G>A	c.(1474-1476)GCC>ACC	p.A492T	NLRP5_uc002qmi.2_Missense_Mutation_p.A473T	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	492	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GGAGAGCGTCGCCCCCTTCAA	0.637													A	56539073	A	A	56539073	3	1	156	1	0	0	0	0	1	0	0	0	10480	1087	38	1	1500	1	NLRP5	19	56539073	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	1037077	56539073	2589910	105	11081											
VPS16	64601	broad.mit.edu	37	chr20	2843940	2843940	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaccgggtctaccaggctcGtgttgcggagactttacccc	11	15	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr20:2843940G>A	uc002whe.2	+	15	1420	c.1372G>A	c.(1372-1374)GTG>ATG	p.V458M	VPS16_uc002whh.2_RNA|PTPRA_uc002whj.2_5'Flank|VPS16_uc002whf.2_Missense_Mutation_p.V314M|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Missense_Mutation_p.V144M|VPS16_uc002whi.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	458					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						TACCAGGCTCGTGTTGCGGAG	0.592													A	2843940	A	A	2843940	3	1	156	1	0	0	0	0	1	0	0	0	17190	1145	40	1	1430	1	VPS16	20	2843940	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08		2843940	60181580	106	11082											
SMOX	54498	broad.mit.edu	37	chr20	4162543	4162543	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttcacccgagaggaggtgCgtaaccgcatcaggaatgac	13	10	2	2			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr20:4162543C>T	uc002wkm.1	+	4	730	c.529C>T	c.(529-531)CGT>TGT	p.R177C	SMOX_uc002wkk.1_Missense_Mutation_p.R177C|SMOX_uc002wkl.1_Missense_Mutation_p.R177C|SMOX_uc002wkn.1_Intron|SMOX_uc002wkp.2_Missense_Mutation_p.R177C|SMOX_uc010zqo.1_Missense_Mutation_p.R154C|SMOX_uc002wko.1_Missense_Mutation_p.R177C	NM_175839	NP_787033	Q9NWM0	SMOX_HUMAN	spermine oxidase isoform 1	177					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)	1					Spermine(DB00127)	AGAGGAGGTGCGTAACCGCAT	0.537													T	4162543	T	T	4162543	3	4	156	1	0	0	0	0	1	0	0	0	14803	768	27	1	539	1	SMOX	20	4162543	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	1318603	4162543	58862977	107	11083											
ZNF831	128611	broad.mit.edu	37	chr20	57767832	57767832	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcccgcagaggacacagaCgcaaagagaactgctgcgcg	14	12	0	3			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr20:57767832C>T	uc002yan.2	+	1	1758	c.1758C>T	c.(1756-1758)GAC>GAT	p.D586D		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	586						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGGACACAGACGCAAAGAGAA	0.672													T	57767832	T	T	57767832	2	4	156	1	0	0	0	0	0	0	0	1	18182	535	19	1		1	ZNF831	20	57767832	Silent	SNP	C	TCGA-19-2623-01A-01D-1495-08	53605289	57767832	5257688	108	11084											
SAMSN1	64092	broad.mit.edu	37	chr21	15889263	15889263	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttacccacttttttcttcaTtgtccatgaaatagctctca	3	11	3	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chr21:15889263T>C	uc002yju.1	-	3	311	c.229A>G	c.(229-231)ATG>GTG	p.M77V	SAMSN1_uc010gky.1_Intron|SAMSN1_uc002yjv.1_Missense_Mutation_p.M145V	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	77					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		TTTTTCTTCATTGTCCATGAA	0.338													C	15889263	C	C	15889263	3	2	156	1	0	0	0	0	1	0	0	0	13830	1493	52	4	916	4	SAMSN1	21	15889263	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08		15889263	32240632	109	11085											
PCYT1B	9468	broad.mit.edu	37	chrX	24580418	24580418	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tcccagcagcctctacttttCatcctcatccccctcgctca	3	20	4	0			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chrX:24580418C>G	uc004dbi.2	-	8	1335	c.1102G>C	c.(1102-1104)GAA>CAA	p.E368Q	PCYT1B_uc004dbk.3_Intron|PCYT1B_uc004dbj.2_Missense_Mutation_p.E350Q	NM_004845	NP_004836	Q9Y5K3	PCY1B_HUMAN	choline phosphate cytidylyltransferase 1 beta	368						endoplasmic reticulum	choline-phosphate cytidylyltransferase activity				0					Choline(DB00122)	CTCTACTTTTCATCCTCATCC	0.577													G	24580418	G	G	24580418	3	3	156	1	0	0	0	0	1	0	0	0	11611	835	29	5	48	5	PCYT1B	23	24580418	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08		24580418	130690142	110	11086											
DMD	1756	broad.mit.edu	37	chrX	32563337	32563337	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttggggaggtggtggtggaaGttcctcttgagcatgcttta	16	5	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chrX:32563337G>T	uc004dda.1	-	17	2351	c.2107C>A	c.(2107-2109)CTT>ATT	p.L703I	DMD_uc004dcz.2_Missense_Mutation_p.L580I|DMD_uc004dcy.1_Missense_Mutation_p.L699I|DMD_uc004ddb.1_Missense_Mutation_p.L695I|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.L695I	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	703					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGTGGTGGAAGTTCCTCTTGA	0.448													T	32563337	T	T	32563337	3	4	156	1	0	0	0	0	1	0	0	0	4580	1029	36	5	9445	5	DMD	23	32563337	Missense_Mutation	SNP	G	TCGA-19-2623-01A-01D-1495-08	7982919	32563337	122707223	111	11087											
CXorf22	170063	broad.mit.edu	37	chrX	35989828	35989828	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcagcaaattcaattagagCgaatcgattgttaaccacca	7	9	1	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chrX:35989828C>T	uc004ddj.2	+	12	2155	c.2096C>T	c.(2095-2097)GCG>GTG	p.A699V	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	699										large_intestine(1)|lung(1)|ovary(1)	3						TCAATTAGAGCGAATCGATTG	0.448													T	35989828	T	T	35989828	3	4	156	1	0	0	0	0	1	0	0	0	4102	768	27	1	2142	1	CXorf22	23	35989828	Missense_Mutation	SNP	C	TCGA-19-2623-01A-01D-1495-08	3426491	35989828	119280732	112	11088											
THOC2	57187	broad.mit.edu	37	chrX	122799597	122799597	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catattgaacacgtctctccTcaaatcttcaaagctctcag	4	13	5	1			TCGA-19-2623-01A-01D-1495-08	TCGA-19-2623-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a14ae5c3-fee0-4ed7-9080-51056ce62ef2	7fc42b4d-ca22-4f63-a0f3-16c2ae0aa213	g.chrX:122799597T>C	uc004etu.2	-	12	1314	c.1282A>G	c.(1282-1284)AGG>GGG	p.R428G	THOC2_uc011muh.1_Missense_Mutation_p.R349G|THOC2_uc011mui.1_Missense_Mutation_p.R313G	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	428					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						ACGTCTCTCCTCAAATCTTCA	0.403													C	122799597	C	C	122799597	3	2	156	1	0	0	0	0	1	0	0	0	15862	1550	54	4	3607	4	THOC2	23	122799597	Missense_Mutation	SNP	T	TCGA-19-2623-01A-01D-1495-08	86809769	122799597	32470963	113	11089											
CDK11A	728642	broad.mit.edu	37	chr1	1636296	1636296	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aggacagcacggggccctgtCggaaaagccttccacccggg	14	14	0	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr1:1636296C>T	uc010nyt.1	-	13	1613	c.1505G>A	c.(1504-1506)CGA>CAA	p.R502Q	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_5'UTR|CDK11A_uc009vkp.2_Intron|CDK11A_uc009vkq.2_Intron|CDK11A_uc009vkr.2_Intron|CDK11A_uc009vks.2_Intron|CDK11A_uc010nys.1_Intron			Q9UQ88	CD11A_HUMAN	SubName: Full=cDNA FLJ56415, highly similar to PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22);	Error:Variant_position_missing_in_Q9UQ88_after_alignment					apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						GGGGCCCTGTCGGAAAAGCCT	0.607													T	1636296	T	T	1636296	3	4	157	1	0	0	0	0	1	0	0	0	3126	899	31	2		2	CDK11A	1	1636296	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08		1636296	247614325	1	11090											
HES5	388585	broad.mit.edu	37	chr1	2461382	2461382	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcgaactcctgctccagcagCagcttcagctgctcgatgct	10	15	1	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr1:2461382C>G	uc001ajn.2	-	2	204	c.123G>C	c.(121-123)CTG>CTC	p.L41L		NM_001010926	NP_001010926	Q5TA89	HES5_HUMAN	hairy and enhancer of split 5	41	Helix-loop-helix motif.				transcription, DNA-dependent	nucleus					0	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;4.41e-16)|all_lung(118;6.66e-07)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Lung SC(97;0.109)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;2.59e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000326)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.199)		GCTCCAGCAGCAGCTTCAGCT	0.647													G	2461382	G	G	2461382	2	3	157	1	0	0	0	0	0	0	0	1	7069	697	25	5		5	HES5	1	2461382	Silent	SNP	C	TCGA-19-2624-01A-01D-1495-08	825086	2461382	246789239	2	11091											
PTPRF	5792	broad.mit.edu	37	chr1	44085120	44085120	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtacgtgttcatccatgaggCgctgctggaggctgccacgt	14	11	1	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr1:44085120C>A	uc001cjr.2	+	28	5148	c.4808C>A	c.(4807-4809)GCG>GAG	p.A1603E	PTPRF_uc001cjs.2_Missense_Mutation_p.A1594E|PTPRF_uc001cju.2_Missense_Mutation_p.A992E|PTPRF_uc009vwt.2_Missense_Mutation_p.A1163E|PTPRF_uc001cjv.2_Missense_Mutation_p.A1074E|PTPRF_uc001cjw.2_Missense_Mutation_p.A829E	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1603	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATCCATGAGGCGCTGCTGGAG	0.607													A	44085120	A	A	44085120	3	1	157	1	0	0	0	0	1	0	0	0	12801	768	27	5	4910	5	PTPRF	1	44085120	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	41623738	44085120	205165501	3	11092											
KANK4	163782	broad.mit.edu	37	chr1	62728946	62728946	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgacttccggctggagacgCggaaccactcttgactgatg	12	12	1	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr1:62728946C>T	uc001dah.3	-	7	2734	c.2357G>A	c.(2356-2358)CGC>CAC	p.R786H	KANK4_uc001dai.3_Missense_Mutation_p.R158H|KANK4_uc001daf.3_5'UTR|KANK4_uc001dag.3_Missense_Mutation_p.R142H	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	786				R -> H (in Ref. 1; BAC03774).						ovary(3)|skin(2)|lung(1)	6						GCTGGAGACGCGGAACCACTC	0.562													T	62728946	T	T	62728946	3	4	157	1	0	0	0	0	1	0	0	0	7979	768	27	1	646	1	KANK4	1	62728946	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	18643826	62728946	186521675	4	11093											
CSDE1	7812	broad.mit.edu	37	chr1	115272925	115272925	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tggttttaggattggaaaaaGtggcttctttttctaccgtg	11	5	2	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr1:115272925G>C	uc001efk.2	-	12	1776	c.1310C>G	c.(1309-1311)ACT>AGT	p.T437S	CSDE1_uc001efi.2_Missense_Mutation_p.T483S|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.T406S|CSDE1_uc001efm.2_Missense_Mutation_p.T452S|CSDE1_uc009wgv.2_Missense_Mutation_p.T437S|CSDE1_uc001efn.2_Missense_Mutation_p.T406S	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	437					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATTGGAAAAAGTGGCTTCTTT	0.378													C	115272925	C	C	115272925	3	2	157	1	0	0	0	0	1	0	0	0	3929	1029	36	5	1122	5	CSDE1	1	115272925	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	52543979	115272925	133977696	5	11094											
F11R	50848	broad.mit.edu	37	chr1	160970003	160970003	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacgggtgcttttgggattcGtaggcatcactatcccatct	10	11	2	0	rs144844671	by1000genomes	TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr1:160970003G>A	uc009wtt.2	-	5	794	c.524C>T	c.(523-525)ACG>ATG	p.T175M	F11R_uc010pjv.1_Missense_Mutation_p.T126M|F11R_uc001fxe.3_Missense_Mutation_p.T175M|F11R_uc009wtu.2_Missense_Mutation_p.T175M|F11R_uc010pjw.1_Missense_Mutation_p.T179M|F11R_uc001fxf.3_Missense_Mutation_p.T175M	NM_016946	NP_058642	Q9Y624	JAM1_HUMAN	F11 receptor precursor	175	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				ovary(2)	2	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			TTTGGGATTCGTAGGCATCAC	0.517													A	160970003	A	A	160970003	3	1	157	1	0	0	0	0	1	0	0	0	5338	1145	40	1	399	1	F11R	1	160970003	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	45697078	160970003	88280618	6	11095											
LAMC1	3915	broad.mit.edu	37	chr1	183101569	183101569	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgatgacattgttcgagtgGcaaagacagccaatgatacg	11	8	0	4			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr1:183101569G>A	uc001gpy.3	+	21	3858	c.3601G>A	c.(3601-3603)GCA>ACA	p.A1201T		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1201	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTTCGAGTGGCAAAGACAGC	0.388													A	183101569	A	A	183101569	3	1	157	1	0	0	0	0	1	0	0	0	8614	1203	42	3	3683	3	LAMC1	1	183101569	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	22131566	183101569	66149052	7	11096											
ZC3H11A	9877	broad.mit.edu	37	chr1	203818961	203818961	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagtcttgacacctcttcgGggagatgtagcctcttgcaa	10	11	4	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr1:203818961G>A	uc001hac.2	+	17	2362	c.1746G>A	c.(1744-1746)CGG>CGA	p.R582R	ZC3H11A_uc001had.2_Silent_p.R582R|ZC3H11A_uc001hae.2_Silent_p.R582R|ZC3H11A_uc001haf.2_Silent_p.R582R|ZC3H11A_uc010pqm.1_Silent_p.R528R|ZC3H11A_uc001hag.1_Silent_p.R582R	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	582							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CACCTCTTCGGGGAGATGTAG	0.493													A	203818961	A	A	203818961	2	1	157	1	0	0	0	0	0	0	0	1	17557	1219	43	3		3	ZC3H11A	1	203818961	Silent	SNP	G	TCGA-19-2624-01A-01D-1495-08	20717392	203818961	45431660	8	11097											
CEP170	9859	broad.mit.edu	37	chr1	243362438	243362438	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttttttcatccacctcatcAtccccccaccatgacggctg	4	18	3	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr1:243362438A>G	uc001hzs.2	-	7	963	c.555T>C	c.(553-555)GAT>GAC	p.D185D	CEP170_uc001hzt.2_Silent_p.D185D|CEP170_uc001hzu.2_Silent_p.D185D	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	185						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			CCACCTCATCATCCCCCCACC	0.428													G	243362438	G	G	243362438	2	3	157	1	0	0	0	0	0	0	0	1	3250	214	8	4		4	CEP170	1	243362438	Silent	SNP	A	TCGA-19-2624-01A-01D-1495-08	39543477	243362438	5888183	9	11098											
TTN	7273	broad.mit.edu	37	chr2	179442793	179442793	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaattgattgccataactcGgaattcatattcaagacctt	5	8	2	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr2:179442793G>A	uc010zfg.1	-	271	60969	c.60745C>T	c.(60745-60747)CGA>TGA	p.R20249*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.R13944*|TTN_uc010zfi.1_Nonsense_Mutation_p.R13877*|TTN_uc010zfj.1_Nonsense_Mutation_p.R13752*|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21176							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCATAACTCGGAATTCATAT	0.423													A	179442793	A	A	179442793	4	1	157	1	0	0	0	0	0	1	0	0	16732	1124	39	2	39694	2	TTN	2	179442793	Nonsense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08		179442793	63756580	10	11099											
KCTD18	130535	broad.mit.edu	37	chr2	201371625	201371625	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcgaccactgaacatagatgCcaacatggagtccttgaagc	10	11	0	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr2:201371625C>A	uc002uvs.2	-	2	632	c.115G>T	c.(115-117)GCA>TCA	p.A39S	KCTD18_uc002uvt.2_Missense_Mutation_p.A39S|KCTD18_uc002uvu.1_Missense_Mutation_p.A39S	NM_152387	NP_689600	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain	39	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1						AACATAGATGCCAACATGGAG	0.458													A	201371625	A	A	201371625	3	1	157	1	0	0	0	0	1	0	0	0	8105	739	26	5	1189	5	KCTD18	2	201371625	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	21928832	201371625	41827748	11	11100											
PARD3B	117583	broad.mit.edu	37	chr2	205986432	205986432	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggctctcttaacatttttggTaataatgatggcgttttgaa	9	5	1	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr2:205986432T>C	uc002var.1	+	8	1131	c.924T>C	c.(922-924)GGT>GGC	p.G308G	PARD3B_uc010fub.1_Silent_p.G308G|PARD3B_uc002vao.1_Silent_p.G308G|PARD3B_uc002vap.1_Silent_p.G308G|PARD3B_uc002vaq.1_Silent_p.G308G	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	308					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		ACATTTTTGGTAATAATGATG	0.453													C	205986432	C	C	205986432	2	2	157	1	0	0	0	0	0	0	0	1	11444	1625	57	4		4	PARD3B	2	205986432	Silent	SNP	T	TCGA-19-2624-01A-01D-1495-08	4614807	205986432	37212941	12	11101											
ALPP	250	broad.mit.edu	37	chr2	233244353	233244353	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaccagtgcaacacgacacGcggcaacgaggtcatctccg	10	14	2	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr2:233244353G>A	uc002vsq.2	+	4	605	c.440G>A	c.(439-441)CGC>CAC	p.R147H	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	147						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		AACACGACACGCGGCAACGAG	0.607													A	233244353	A	A	233244353	3	1	157	1	0	0	0	0	1	0	0	0	548	1087	38	1	454	1	ALPP	2	233244353	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	27257921	233244353	9955020	13	11102											
HES1	3280	broad.mit.edu	37	chr3	193855643	193855643	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccagatcaatgccatgacctAccccgggcagccgcaccccg	9	19	1	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr3:193855643A>C	uc003ftq.1	+	4	700	c.464A>C	c.(463-465)TAC>TCC	p.Y155S		NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	155					endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		GCCATGACCTACCCCGGGCAG	0.731													C	193855643	C	C	193855643	3	2	157	1	0	0	0	0	1	0	0	0	7065	391	14	5	478	5	HES1	3	193855643	Missense_Mutation	SNP	A	TCGA-19-2624-01A-01D-1495-08		193855643	4166787	14	11103											
PLCXD3	345557	broad.mit.edu	37	chr5	41313846	41313846	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctcctggcttctgcgtgcggAcccactgcatcatggcagga	12	14	2	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr5:41313846A>T	uc003jmm.1	-	3	941	c.839T>A	c.(838-840)GTC>GAC	p.V280D		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	280					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						CTGCGTGCGGACCCACTGCAT	0.433													T	41313846	T	T	41313846	3	4	157	1	0	0	0	0	1	0	0	0	12043	275	10	5	130	5	PLCXD3	5	41313846	Missense_Mutation	SNP	A	TCGA-19-2624-01A-01D-1495-08		41313846	139601414	15	11104											
NMUR2	56923	broad.mit.edu	37	chr5	151784217	151784217	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtgctctgcagtttggcgCggaacgggtgtaggatggcc	19	8	1	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr5:151784217C>T	uc003luv.2	-	1	624	c.458G>A	c.(457-459)CGC>CAC	p.R153H		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	153	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			CAGTTTGGCGCGGAACGGGTG	0.637													T	151784217	T	T	151784217	3	4	157	1	0	0	0	0	1	0	0	0	10507	768	27	1	805	1	NMUR2	5	151784217	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	110470371	151784217	29131043	16	11105											
DOCK2	1794	broad.mit.edu	37	chr5	169508958	169508958	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gacaagaagacactcacacgGaagaaggtcaatcagttctt	9	9	4	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr5:169508958G>A	uc003maf.2	+	51	5480	c.5400G>A	c.(5398-5400)CGG>CGA	p.R1800R	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.R1292R|DOCK2_uc003mah.2_Silent_p.R356R	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1800					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CACTCACACGGAAGAAGGTCA	0.527													A	169508958	A	A	169508958	2	1	157	1	0	0	0	0	0	0	0	1	4687	1161	41	3		3	DOCK2	5	169508958	Silent	SNP	G	TCGA-19-2624-01A-01D-1495-08	17724741	169508958	11406302	17	11106											
C6orf195	154386	broad.mit.edu	37	chr6	2623743	2623743	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttctcagatggcagggagtgGcctggtcactgttgatcttg	14	8	3	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr6:2623743G>C	uc003mtw.2	-	3	1299	c.314C>G	c.(313-315)GCC>GGC	p.A105G		NM_152554	NP_689767	Q96MT4	CF195_HUMAN	hypothetical protein LOC154386	105											0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				GCAGGGAGTGGCCTGGTCACT	0.547													C	2623743	C	C	2623743	3	2	157	1	0	0	0	0	1	0	0	0	2350	1203	42	5	73	5	C6orf195	6	2623743	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08		2623743	168491324	18	11107											
LRRC1	55227	broad.mit.edu	37	chr6	53784332	53784332	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttatccctgactgccttgaaGttgaaggctctgtggctatc	10	10	1	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr6:53784332G>C	uc003pcd.1	+	12	1420	c.1143G>C	c.(1141-1143)AAG>AAC	p.K381N		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	381						cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		CTGCCTTGAAGTTGAAGGCTC	0.398													C	53784332	C	C	53784332	3	2	157	1	0	0	0	0	1	0	0	0	8966	1020	36	5	1189	5	LRRC1	6	53784332	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	51160589	53784332	117330735	19	11108											
AKD1	221264	broad.mit.edu	37	chr6	109993332	109993332	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtttaccataactcctgattCggtttcagcagcaatctgtt	7	10	2	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr6:109993332C>T	uc003ptn.2	-	4	297	c.220G>A	c.(220-222)GAA>AAA	p.E74K	AKD1_uc003ptr.3_Missense_Mutation_p.E74K|AKD1_uc003pts.1_RNA	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	74					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						ACTCCTGATTCGGTTTCAGCA	0.279													T	109993332	T	T	109993332	3	4	157	1	0	0	0	0	1	0	0	0	460	893	31	2	5679	2	AKD1	6	109993332	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	56209000	109993332	61121735	20	11109											
VNN1	8876	broad.mit.edu	37	chr6	133005540	133005540	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggaaagacatactgggttccGaaagtgccactgagggagaa	14	7	0	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr6:133005540G>A	uc003qdo.2	-	6	1313	c.1293C>T	c.(1291-1293)TTC>TTT	p.F431F	VNN1_uc003qdn.2_RNA	NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	431					acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		ACTGGGTTCCGAAAGTGCCAC	0.418													A	133005540	A	A	133005540	2	1	157	1	0	0	0	0	0	0	0	1	17179	1049	37	2		2	VNN1	6	133005540	Silent	SNP	G	TCGA-19-2624-01A-01D-1495-08	23012208	133005540	38109527	21	11110											
C7orf28A	51622	broad.mit.edu	37	chr7	5959509	5959509	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccaacgttggatttttgcCgaagactggacagcatcgtt	10	10	0	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr7:5959509C>T	uc003spf.2	+	12	1108	c.1018C>T	c.(1018-1020)CGA>TGA	p.R340*		NM_015622	NP_056437	P86791	CCZ1_HUMAN	hypothetical protein LOC51622	340						lysosomal membrane					0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0974)|OV - Ovarian serous cystadenocarcinoma(56;7.91e-15)		GGATTTTTGCCGAAGACTGGA	0.468													T	5959509	T	T	5959509	4	4	157	1	0	0	0	0	0	1	0	0	2383	644	23	2	1064	2	C7orf28A	7	5959509	Nonsense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08		5959509	153179154	22	11111											
EGFR	1956	broad.mit.edu	37	chr7	55210077	55210078	+	Missense_Mutation	DNP	GG	AA	AA													ataactgtgaggtggtccttGggaatttggaaattacctat							TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr7:55210077_55210078GG>AA	uc003tqk.2	+	2	433_434	c.187_188GG>AA	c.(187-189)GGG>AAG	p.G63K	EGFR_uc003tqh.2_Missense_Mutation_p.G63K|EGFR_uc003tqi.2_Missense_Mutation_p.G63K|EGFR_uc003tqj.2_Missense_Mutation_p.G63K|EGFR_uc010kzg.1_Missense_Mutation_p.G63K|EGFR_uc011kco.1_Missense_Mutation_p.G10K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	63	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.G63R(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGTGGTCCTTGGGAATTTGGAA	0.396		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			AA	55210078	AA	AA	55210077	3	1	157	1	0	0	0	0	1	0	0	0	4967	1348	47	3	193	3	EGFR	7	55210077	Missense_Mutation	DNP	GG	TCGA-19-2624-01A-01D-1495-08	49250568	55210077	103928586	23	11112											
STEAP1	26872	broad.mit.edu	37	chr7	89794038	89794038	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	taacaaaactgagatatgttCccagttgtagaattactgtt	7	6	0	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr7:89794038C>A	uc003ujx.2	+	5	1210	c.1010C>A	c.(1009-1011)TCC>TAC	p.S337Y	STEAP2_uc003ujy.2_5'Flank	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	337					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					GAGATATGTTCCCAGTTGTAG	0.299													A	89794038	A	A	89794038	3	1	157	1	0	0	0	0	1	0	0	0	15276	855	30	5	1024	5	STEAP1	7	89794038	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	34583961	89794038	69344625	24	11113											
LHFPL3	375612	broad.mit.edu	37	chr7	104377161	104377161	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctgtatgattttccctgatgGctgggactcagatgaagtaa	11	7	1	4			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr7:104377161G>C	uc003vce.2	+	2	609	c.485G>C	c.(484-486)GGC>GCC	p.G162A	LHFPL3_uc003vcf.2_Missense_Mutation_p.G162A	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	148						integral to membrane					0						TTCCCTGATGGCTGGGACTCA	0.418													C	104377161	C	C	104377161	3	2	157	1	0	0	0	0	1	0	0	0	8766	1203	42	5	491	5	LHFPL3	7	104377161	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	14583123	104377161	54761502	25	11114											
DAB2IP	153090	broad.mit.edu	37	chr9	124538504	124538504	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggtgctgcaggacaagctgCgaatctccaccaagaagctg	12	12	1	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr9:124538504C>T	uc004bln.2	+	14	3133	c.3064C>T	c.(3064-3066)CGA>TGA	p.R1022*	DAB2IP_uc004blo.2_Nonsense_Mutation_p.R926*|DAB2IP_uc004blp.2_Nonsense_Mutation_p.R455*	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	1050	Potential.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						GGACAAGCTGCGAATCTCCAC	0.622													T	124538504	T	T	124538504	4	4	157	1	0	0	0	0	0	1	0	0	4219	760	27	1	3118	1	DAB2IP	9	124538504	Nonsense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08		124538504	16674927	26	11115											
ALDH18A1	5832	broad.mit.edu	37	chr10	97396856	97396856	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcccagcctctcacctgggcAgcacagatgctgtactgggt	12	14	1	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr10:97396856A>T	uc001kkz.2	-	5	794	c.552T>A	c.(550-552)GCT>GCA	p.A184A	ALDH18A1_uc001kky.2_Silent_p.A184A|ALDH18A1_uc010qog.1_Silent_p.A73A|ALDH18A1_uc010qoh.1_Intron	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	184	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	TCACCTGGGCAGCACAGATGC	0.458													T	97396856	T	T	97396856	2	4	157	1	0	0	0	0	0	0	0	1	489	175	7	5		5	ALDH18A1	10	97396856	Silent	SNP	A	TCGA-19-2624-01A-01D-1495-08		97396856	38137891	27	11116											
ADAM8	101	broad.mit.edu	37	chr10	135084467	135084467	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccccggagcagggcgtgccGttctcctggaaggcgtcttc	14	15	2	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr10:135084467G>A	uc010qva.1	-	13	1416	c.1365C>T	c.(1363-1365)AAC>AAT	p.N455N	ADAM8_uc010quz.1_Silent_p.N494N|ADAM8_uc009ybi.2_Silent_p.N494N			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	455					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		AGGGCGTGCCGTTCTCCTGGA	0.667													A	135084467	A	A	135084467	2	1	157	1	0	0	0	0	0	0	0	1	252	1136	40	1		1	ADAM8	10	135084467	Silent	SNP	G	TCGA-19-2624-01A-01D-1495-08	37687611	135084467	450280	28	11117											
C11orf35	256329	broad.mit.edu	37	chr11	558885	558885	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagagcagaccaccggtgcGgggtggggcgtggtgtctgg	21	9	1	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr11:558885G>A	uc001lpx.2	-	2	192	c.129C>T	c.(127-129)CCC>CCT	p.P43P	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank|RASSF7_uc001lqb.2_5'Flank|RASSF7_uc001lqc.2_5'Flank|RASSF7_uc001lqd.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	43										pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCACCGGTGCGGGGTGGGGCG	0.692													A	558885	A	A	558885	2	1	157	1	0	0	0	0	0	0	0	1	1638	1103	39	2		2	C11orf35	11	558885	Silent	SNP	G	TCGA-19-2624-01A-01D-1495-08		558885	134447631	29	11118											
OR51E2	81285	broad.mit.edu	37	chr11	4703127	4703127	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatgtcacccatgacaacaCgcacaatgggatgaaggctg	11	10	1	3	rs138231892		TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr11:4703127C>T	uc001lzk.2	-	2	1059	c.815G>A	c.(814-816)CGT>CAT	p.R272H		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CATGACAACACGCACAATGGG	0.507													T	4703127	T	T	4703127	3	4	157	1	0	0	0	0	1	0	0	0	11095	536	19	1	151	1	OR51E2	11	4703127	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	4144242	4703127	130303389	30	11119											
OR52N4	390072	broad.mit.edu	37	chr11	5776764	5776764	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctccttcttttcccaccGctttggggaacacataatcc	5	15	2	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr11:5776764G>A	uc001mbu.2	+	1	842	c.794G>A	c.(793-795)CGC>CAC	p.R265H	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TTTTCCCACCGCTTTGGGGAA	0.468													A	5776764	A	A	5776764	3	1	157	1	0	0	0	0	1	0	0	0	11129	1087	38	1	796	1	OR52N4	11	5776764	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	1073637	5776764	129229752	31	11120											
OR8I2	120586	broad.mit.edu	37	chr11	55861299	55861299	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttggcgttctgtgattccagCatcaatcattttttttgtga	8	7	3	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr11:55861299C>A	uc010rix.1	+	1	516	c.516C>A	c.(514-516)AGC>AGA	p.S172R		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					GTGATTCCAGCATCAATCATT	0.448													A	55861299	A	A	55861299	3	1	157	1	0	0	0	0	1	0	0	0	11240	709	25	5	518	5	OR8I2	11	55861299	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	50084535	55861299	79145217	32	11121											
TBC1D10C	374403	broad.mit.edu	37	chr11	67177159	67177159	+	Frame_Shift_Del	DEL	C	-	-													ctcctgactcgggcccggggCccccccatcgaggggccccc							TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr11:67177159delC	uc001ola.2	+	10	1304	c.1275delC	c.(1273-1275)GGCfs	p.G425fs	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_3'UTR|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	425	Interaction with calcineurin.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GGGCCCGGGGCCCCCCCATCG	0.682													-	67177159	-	-	67177159	7	5	157	1	0	1	0	1	0	0	0	0	15597	726	26	0	1309	0	TBC1D10C	11	67177159	Frame_Shift_Del	DEL	C	TCGA-19-2624-01A-01D-1495-08	11315860	67177159	67829357	33	11122											
ST14	6768	broad.mit.edu	37	chr11	130069857	130069857	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctctgcagactgtgggctgCggtcattcacgagacaggct	13	12	3	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr11:130069857C>T	uc001qfw.2	+	16	2012	c.1819C>T	c.(1819-1821)CGG>TGG	p.R607W		NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	607	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	CTGTGGGCTGCGGTCATTCAC	0.612													T	130069857	T	T	130069857	3	4	157	1	0	0	0	0	1	0	0	0	15210	759	27	1	1881	1	ST14	11	130069857	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	62892698	130069857	4936659	34	11123											
FOXJ2	55810	broad.mit.edu	37	chr12	8201337	8201337	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atattgactctttaaaggaaAgcttcaagatggtgaatcgg	10	5	2	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr12:8201337A>G	uc001qtu.2	+	8	2355	c.1270A>G	c.(1270-1272)AGC>GGC	p.S424G	FOXJ2_uc001qtt.1_Missense_Mutation_p.S424G	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	424					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)		TTTAAAGGAAAGCTTCAAGAT	0.428													G	8201337	G	G	8201337	3	3	157	1	0	0	0	0	1	0	0	0	6012	72	3	4	1296	4	FOXJ2	12	8201337	Missense_Mutation	SNP	A	TCGA-19-2624-01A-01D-1495-08		8201337	125650558	35	11124											
CACNB3	784	broad.mit.edu	37	chr12	49217552	49217552	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtccagggctctggagtcaActttgaggccaaagattttc	11	9	2	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr12:49217552A>G	uc001rsl.1	+	3	458	c.257A>G	c.(256-258)AAC>AGC	p.N86S	CACNB3_uc010slx.1_Missense_Mutation_p.N73S|CACNB3_uc010sly.1_Missense_Mutation_p.N73S|CACNB3_uc010slz.1_Missense_Mutation_p.N85S|CACNB3_uc001rsk.1_5'UTR	NM_000725	NP_000716	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3	86	SH3.				axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0					Verapamil(DB00661)	TCTGGAGTCAACTTTGAGGCC	0.493													G	49217552	G	G	49217552	3	3	157	1	0	0	0	0	1	0	0	0	2554	43	2	4	267	4	CACNB3	12	49217552	Missense_Mutation	SNP	A	TCGA-19-2624-01A-01D-1495-08	41016215	49217552	84634343	36	11125											
ESPL1	9700	broad.mit.edu	37	chr12	53662942	53662942	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcttgccctaggcatctgggGagcctgctggagctggcaga	16	11	1	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr12:53662942G>A	uc001sck.2	+	3	307	c.216G>A	c.(214-216)GGG>GGA	p.G72G	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	72					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GGCATCTGGGGAGCCTGCTGG	0.567													A	53662942	A	A	53662942	2	1	157	1	0	0	0	0	0	0	0	1	5253	1161	41	3		3	ESPL1	12	53662942	Silent	SNP	G	TCGA-19-2624-01A-01D-1495-08	4445390	53662942	80188953	37	11126											
NEDD1	121441	broad.mit.edu	37	chr12	97345747	97345747	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgaaatgcattctttgctGgaaagatactcagtgaatga	9	5	2	4			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr12:97345747G>A	uc001teu.3	+	16	2238	c.1899G>A	c.(1897-1899)CTG>CTA	p.L633L	NEDD1_uc001tev.3_Silent_p.L633L|NEDD1_uc010svc.1_Silent_p.L544L|NEDD1_uc001tew.2_Silent_p.L640L|NEDD1_uc001tex.2_Silent_p.L544L	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	633					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						ATTCTTTGCTGGAAAGATACT	0.323													A	97345747	A	A	97345747	2	1	157	1	0	0	0	0	0	0	0	1	10309	1335	47	3		3	NEDD1	12	97345747	Silent	SNP	G	TCGA-19-2624-01A-01D-1495-08	43682805	97345747	36506148	38	11127											
ATXN2	6311	broad.mit.edu	37	chr12	111895056	111895056	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggatgacttccaccatgttGgctttgctgctgtccagtgg	12	10	0	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr12:111895056G>A	uc001tsj.2	-	22	3640	c.3478C>T	c.(3478-3480)CAA>TAA	p.Q1160*	ATXN2_uc001tsh.2_Nonsense_Mutation_p.Q895*|ATXN2_uc001tsi.2_Nonsense_Mutation_p.Q853*|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Nonsense_Mutation_p.Q348*|ATXN2_uc001tsl.1_Nonsense_Mutation_p.Q161*	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	1160					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CCACCATGTTGGCTTTGCTGC	0.552													A	111895056	A	A	111895056	4	1	157	1	0	0	0	0	0	1	0	0	1211	1357	47	3	479	3	ATXN2	12	111895056	Nonsense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	14549309	111895056	21956839	39	11128											
FZD10	11211	broad.mit.edu	37	chr12	130648665	130648665	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcagcatggacgtcaacgCgctcaccggcttcgtgctca	13	14	3	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr12:130648665C>T	uc001uii.2	+	1	1634	c.1178C>T	c.(1177-1179)GCG>GTG	p.A393V	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	393	Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GACGTCAACGCGCTCACCGGC	0.657													T	130648665	T	T	130648665	3	4	157	1	0	0	0	0	1	0	0	0	6129	768	27	1	1180	1	FZD10	12	130648665	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	18753609	130648665	3203230	40	11129											
CYP46A1	10858	broad.mit.edu	37	chr14	100166408	100166408	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagcgctggcacaagcagcGgagagtcatagacctggcct	14	11	1	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr14:100166408G>A	uc001ygo.2	+	5	413	c.413G>A	c.(412-414)CGG>CAG	p.R138Q	CYP46A1_uc001ygn.1_Missense_Mutation_p.R100Q	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	138					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CACAAGCAGCGGAGAGTCATA	0.592													A	100166408	A	A	100166408	3	1	157	1	0	0	0	0	1	0	0	0	4182	1116	39	2	431	2	CYP46A1	14	100166408	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08		100166408	7183132	41	11130											
AHNAK2	113146	broad.mit.edu	37	chr14	105410901	105410901	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgtctttggcagtcacgtcCttgtcagccagggacaggtc	12	12	3	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr14:105410901C>A	uc010axc.1	-	7	11007	c.10887G>T	c.(10885-10887)AAG>AAT	p.K3629N	AHNAK2_uc001ypx.2_Missense_Mutation_p.K3529N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3629						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CAGTCACGTCCTTGTCAGCCA	0.597													A	105410901	A	A	105410901	3	1	157	1	0	0	0	0	1	0	0	0	415	680	24	5	6504	5	AHNAK2	14	105410901	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	5244493	105410901	1938639	42	11131											
AHNAK2	113146	broad.mit.edu	37	chr14	105418389	105418389	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agcttggctcccggggcctcGacgtccacctccacgctggg	13	17	0	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr14:105418389G>A	uc010axc.1	-	7	3519	c.3399C>T	c.(3397-3399)GTC>GTT	p.V1133V	AHNAK2_uc001ypx.2_Silent_p.V1033V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1133						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCGGGGCCTCGACGTCCACCT	0.632													A	105418389	A	A	105418389	2	1	157	1	0	0	0	0	0	0	0	1	415	1045	37	2		2	AHNAK2	14	105418389	Silent	SNP	G	TCGA-19-2624-01A-01D-1495-08	7488	105418389	1931151	43	11132											
OR4N4	283694	broad.mit.edu	37	chr15	22332433	22332433	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaaaaaacaagattctaacGtgacagaacttgttcttctg	6	7	3	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr15:22332433G>A	uc001yuc.1	+	3	240	c.-741G>A	c.(-743--739)ACGTG>ACATG		LOC727924_uc001ytz.1_Intron|LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		AGATTCTAACGTGACAGAACT	0.328													A	22332433	A	A	22332433	1	1	157	1	0	0	0	0	0	0	0	0	11078	1160	40	1		1	OR4N4	15	22332433	Translation_Start_Site	SNP	G	TCGA-19-2624-01A-01D-1495-08		22332433	80198959	44	11133											
DUOX2	50506	broad.mit.edu	37	chr15	45393418	45393418	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaccgctccccaggtgtcCgagtgatgaacgagactcga	11	14	1	3	rs146664125	byFrequency	TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr15:45393418C>T	uc010bea.2	-	22	3109	c.2906G>A	c.(2905-2907)CGG>CAG	p.R969Q	DUOX2_uc001zun.2_Missense_Mutation_p.R969Q	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	969	Cytoplasmic (Potential).|Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CCCAGGTGTCCGAGTGATGAA	0.547													T	45393418	T	T	45393418	3	4	157	1	0	0	0	0	1	0	0	0	4801	652	23	2	1792	2	DUOX2	15	45393418	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	23060985	45393418	57137974	45	11134											
CCPG1	9236	broad.mit.edu	37	chr15	55652558	55652559	+	Frame_Shift_Ins	INS	-	C	C													tagccctgtggcttcctctgINSccccctttcttttttccatc							TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr15:55652558_55652559insC	uc002acv.1	-	8	1577_1578	c.1412_1413insG	c.(1411-1413)GGCfs	p.G471fs	CCPG1_uc002acy.2_Frame_Shift_Ins_p.G471fs|CCPG1_uc002acu.1_Frame_Shift_Ins_p.G327fs|CCPG1_uc002acw.1_Frame_Shift_Ins_p.G196fs|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Frame_Shift_Ins_p.G471fs|CCPG1_uc002acz.1_Frame_Shift_Ins_p.G471fs	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	471	Lumenal (Potential).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		GGCTTCCTCTGCCCCCTTTCTT	0.391													C	55652559	C	C	55652558	7	5	157	1	0	1	1	0	0	0	0	0	2938	1306	46	0	864	0	CCPG1	15	55652558	Frame_Shift_Ins	INS	-	TCGA-19-2624-01A-01D-1495-08	10259140	55652558	46878834	46	11135											
GFOD2	81577	broad.mit.edu	37	chr16	67709764	67709764	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaggctgcctgagtagatgCgggcatcacagatcatcacc	12	12	3	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr16:67709764C>T	uc002eub.2	-	3	747	c.452G>A	c.(451-453)CGC>CAC	p.R151H	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Missense_Mutation_p.R46H	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	151						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		TGAGTAGATGCGGGCATCACA	0.592													T	67709764	T	T	67709764	3	4	157	1	0	0	0	0	1	0	0	0	6344	768	27	1	709	1	GFOD2	16	67709764	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08		67709764	22644989	47	11136											
CBFA2T3	863	broad.mit.edu	37	chr16	88945788	88945788	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acgctccgtggtgatgagctCgtgcgctttgcgctccgcgt	14	13	0	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr16:88945788C>T	uc002fmm.1	-	11	1738	c.1552G>A	c.(1552-1554)GAG>AAG	p.E518K	CBFA2T3_uc002fml.1_Missense_Mutation_p.E432K|CBFA2T3_uc002fmk.1_Missense_Mutation_p.E17K	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	518	Potential.		E -> K (in a colorectal cancer sample; somatic mutation).		cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E518K(1)		large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		GTGATGAGCTCGTGCGCTTTG	0.657			T	RUNX1	AML								T	88945788	T	T	88945788	3	4	157	1	0	0	0	0	1	0	0	0	2698	893	31	2	417	2	CBFA2T3	16	88945788	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	21236024	88945788	1408965	48	11137											
GPR179	440435	broad.mit.edu	37	chr17	36499303	36499303	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gtaccattccacatcctcctCcacactggactcacggatgt	6	16	1	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr17:36499303C>G	uc002hpz.2	-	1	391	c.370G>C	c.(370-372)GAG>CAG	p.E124Q		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	124	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				ACATCCTCCTCCACACTGGAC	0.627													G	36499303	G	G	36499303	3	3	157	1	0	0	0	0	1	0	0	0	6674	864	30	5	6777	5	GPR179	17	36499303	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08		36499303	44695907	49	11138											
C18orf45	85019	broad.mit.edu	37	chr18	20889650	20889650	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaaaagacttaccatcccGtggttgcactggtcaggatc	10	11	1	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr18:20889650G>A	uc002kuf.2	-	14	933	c.824C>T	c.(823-825)ACG>ATG	p.T275M	C18orf45_uc010xaq.1_RNA|C18orf45_uc010xar.1_RNA|C18orf45_uc002kug.2_RNA|C18orf45_uc002kuh.2_RNA|C18orf45_uc002kue.2_RNA	NM_032933	NP_116322	Q24JQ0	CR045_HUMAN	hypothetical protein LOC85019	275	Helical; (Potential).					integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)					TTACCATCCCGTGGTTGCACT	0.403													A	20889650	A	A	20889650	3	1	157	1	0	0	0	0	1	0	0	0	1903	1145	40	1	74	1	C18orf45	18	20889650	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08		20889650	57187598	50	11139											
MIER2	54531	broad.mit.edu	37	chr19	307371	307371	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagcagtgacagctggctggTatgaggctgggtcggccagg	19	8	0	2			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr19:307371T>C	uc002lok.1	-	13	1373	c.1364A>G	c.(1363-1365)TAC>TGC	p.Y455C		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	455					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTGGCTGGTATGAGGCTGG	0.687													C	307371	C	C	307371	3	2	157	1	0	0	0	0	1	0	0	0	9581	1638	57	4	281	4	MIER2	19	307371	Missense_Mutation	SNP	T	TCGA-19-2624-01A-01D-1495-08		307371	58821612	51	11140											
CHAF1A	10036	broad.mit.edu	37	chr19	4409704	4409704	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgaggggccgcctgctccccCaaagcagcacagcagtacca	11	17	0	0	rs150305585		TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr19:4409704C>A	uc002mal.2	+	3	1008	c.908C>A	c.(907-909)CCA>CAA	p.P303Q		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	303	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGCTCCCCCAAAGCAGCAC	0.612								Chromatin_Structure					A	4409704	A	A	4409704	3	1	157	1	0	0	0	0	1	0	0	0	3311	594	21	5	918	5	CHAF1A	19	4409704	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08	4102333	4409704	54719279	52	11141											
PLEKHG2	64857	broad.mit.edu	37	chr19	39913972	39913972	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggattcccagatgagctgGcattccgctcttgctcagaa	11	11	2	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr19:39913972G>A	uc010xuz.1	+	18	2603	c.2278G>A	c.(2278-2280)GCA>ACA	p.A760T	PLEKHG2_uc010xuy.1_Missense_Mutation_p.A701T|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.A538T	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	760					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGATGAGCTGGCATTCCGCTC	0.597													A	39913972	A	A	39913972	3	1	157	1	0	0	0	0	1	0	0	0	12069	1203	42	3	2344	3	PLEKHG2	19	39913972	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	35504268	39913972	19215011	53	11142											
TGM3	7053	broad.mit.edu	37	chr20	2320632	2320632	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgttgggtaacctgaagatcGagtgagtcctgggcctaagt	14	7	0	3			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr20:2320632G>A	uc002wfx.3	+	12	2030	c.1933G>A	c.(1933-1935)GAC>AAC	p.D645N		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	645					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	CCTGAAGATCGAGTGAGTCCT	0.642													A	2320632	A	A	2320632	3	1	157	1	0	0	0	0	1	0	0	0	15828	1072	37	2	1979	2	TGM3	20	2320632	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08		2320632	60704888	54	11143											
SEMG1	6406	broad.mit.edu	37	chr20	43836470	43836470	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taagtaaagaacaaacttccGtctctggtgcacaaaaaggt	8	8	1	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr20:43836470G>A	uc002xni.2	+	2	589	c.532G>A	c.(532-534)GTC>ATC	p.V178I	SEMG1_uc002xnj.2_Missense_Mutation_p.V178I|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.V178I	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	178	42 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				ACAAACTTCCGTCTCTGGTGC	0.423													A	43836470	A	A	43836470	3	1	157	1	0	0	0	0	1	0	0	0	14044	1145	40	1	538	1	SEMG1	20	43836470	Missense_Mutation	SNP	G	TCGA-19-2624-01A-01D-1495-08	41515838	43836470	19189050	55	11144											
KRTAP6-1	337966	broad.mit.edu	37	chr21	31986055	31986055	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcatccatagccatagccacAgagggagcgggagccatagc	13	12	0	1			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr21:31986055A>T	uc002yop.2	-	1	169	c.169T>A	c.(169-171)TGT>AGT	p.C57S	KRTAP20-1_uc011ade.1_5'Flank	NM_181602	NP_853633	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1	57						cytosol|intermediate filament					0						CCATAGCCACAGAGGGAGCGG	0.567													T	31986055	T	T	31986055	3	4	157	1	0	0	0	0	1	0	0	0	8569	188	7	5	50	5	KRTAP6-1	21	31986055	Missense_Mutation	SNP	A	TCGA-19-2624-01A-01D-1495-08		31986055	16143840	56	11145											
MYH9	4627	broad.mit.edu	37	chr22	36689392	36689392	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacctgggcatggagggtggCgatctgcttctccaggttgt	15	9	2	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chr22:36689392C>T	uc003apg.2	-	30	4309	c.4078G>A	c.(4078-4080)GCC>ACC	p.A1360T		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1360	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGGAGGGTGGCGATCTGCTTC	0.662			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				T	36689392	T	T	36689392	3	4	157	1	0	0	0	0	1	0	0	0	10042	768	27	1	1852	1	MYH9	22	36689392	Missense_Mutation	SNP	C	TCGA-19-2624-01A-01D-1495-08		36689392	14615174	57	11146											
MAGEB18	286514	broad.mit.edu	37	chrX	26157310	26157310	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgcttcagggagccccatccAccaccaatgctattgcacct	7	17	1	0			TCGA-19-2624-01A-01D-1495-08	TCGA-19-2624-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	a8f86b64-914c-4d89-897b-33bcdd1759f7	f9b76b10-6585-4724-a373-3c7915d15bff	g.chrX:26157310A>G	uc004dbq.1	+	2	395	c.208A>G	c.(208-210)ACC>GCC	p.T70A		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	70							protein binding			central_nervous_system(1)	1						AGCCCCATCCACCACCAATGC	0.532													G	26157310	G	G	26157310	3	3	157	1	0	0	0	0	1	0	0	0	9175	159	6	4	210	4	MAGEB18	23	26157310	Missense_Mutation	SNP	A	TCGA-19-2624-01A-01D-1495-08		26157310	129113250	58	11147											
SPOCD1	90853	broad.mit.edu	37	chr1	32280067	32280067	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggggcccatcccctgtagCgggcaaatatccaaatttct	9	13	1	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr1:32280067C>T	uc001bts.1	-	2	926	c.868G>A	c.(868-870)GCT>ACT	p.A290T	SPOCD1_uc001btu.2_Missense_Mutation_p.A290T|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	290					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TCCCCTGTAGCGGGCAAATAT	0.632													T	32280067	T	T	32280067	3	4	158	1	0	0	0	0	1	0	0	0	15077	768	27	1	2842	1	SPOCD1	1	32280067	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08		32280067	216970554	1	11148											
PTPRF	5792	broad.mit.edu	37	chr1	44056912	44056912	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcgaggcagtgcgggcaCgcacgggagaacaggcgccc	17	14	0	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr1:44056912C>T	uc001cjr.2	+	9	1559	c.1219C>T	c.(1219-1221)CGC>TGC	p.R407C	PTPRF_uc001cjs.2_Missense_Mutation_p.R407C|PTPRF_uc001cju.2_Translation_Start_Site|PTPRF_uc009vwt.2_Translation_Start_Site|PTPRF_uc001cjv.2_Translation_Start_Site	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	407	Extracellular (Potential).|Fibronectin type-III 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGTGCGGGCACGCACGGGAGA	0.701													T	44056912	T	T	44056912	3	4	158	1	0	0	0	0	1	0	0	0	12801	536	19	1	1245	1	PTPRF	1	44056912	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	11776845	44056912	205193709	2	11149											
CLCA1	1179	broad.mit.edu	37	chr1	86951220	86951220	+	Frame_Shift_Del	DEL	C	-	-													caaagaattgtgtgtttagtCcttgacaaatctggaagcat							TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr1:86951220delC	uc001dlt.2	+	6	1059	c.930delC	c.(928-930)GTCfs	p.V310fs	CLCA1_uc001dls.1_Frame_Shift_Del_p.V249fs	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	310	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TGTGTTTAGTCCTTGACAAAT	0.448													-	86951220	-	-	86951220	7	5	158	1	0	1	0	1	0	0	0	0	3457	842	30	0	952	0	CLCA1	1	86951220	Frame_Shift_Del	DEL	C	TCGA-19-2625-01A-01D-1495-08	42894308	86951220	162299401	3	11150											
SLAMF6	114836	broad.mit.edu	37	chr1	160465979	160465979	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aggactgggtgaagttcagtCgctttccctgtttcggatta	12	8	1	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr1:160465979C>T	uc001fwe.1	-	2	314	c.254G>A	c.(253-255)CGA>CAA	p.R85Q	SLAMF6_uc001fwd.1_Missense_Mutation_p.R85Q|SLAMF6_uc010pjh.1_Missense_Mutation_p.R36Q|SLAMF6_uc010pji.1_Intron|SLAMF6_uc010pjj.1_Intron|SLAMF6_uc009wtm.1_Missense_Mutation_p.R36Q	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	85	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			GAAGTTCAGTCGCTTTCCCTG	0.463													T	160465979	T	T	160465979	3	4	158	1	0	0	0	0	1	0	0	0	14368	884	31	2	772	2	SLAMF6	1	160465979	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	73514759	160465979	88784642	4	11151											
NPHS2	7827	broad.mit.edu	37	chr1	179520378	179520378	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggaaggacttgggaaggggAggcttccctgagttctgttg	17	6	1	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr1:179520378A>G	uc001gmq.3	-	8	1167	c.1082T>C	c.(1081-1083)CTC>CCC	p.L361P	C1orf125_uc009wxg.2_Intron|C1orf125_uc001gmo.2_Intron|C1orf125_uc001gmp.2_Intron|C1orf125_uc009wxh.2_Intron|NPHS2_uc009wxi.2_Missense_Mutation_p.L293P|C1orf125_uc001gmr.2_RNA	NM_014625	NP_055440	Q9NP85	PODO_HUMAN	podocin	361	Cytoplasmic (Potential).				excretion	integral to plasma membrane	protein binding				0						TGGGAAGGGGAGGCTTCCCTG	0.473													G	179520378	G	G	179520378	3	3	158	1	0	0	0	0	1	0	0	0	10583	304	11	4	73	4	NPHS2	1	179520378	Missense_Mutation	SNP	A	TCGA-19-2625-01A-01D-1495-08	19054399	179520378	69730243	5	11152											
CENPF	1063	broad.mit.edu	37	chr1	214816089	214816089	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agatgcagctgggcttggagGaggggctcgttccatccctg	16	10	0	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr1:214816089G>A	uc001hkm.2	+	12	4582	c.4408G>A	c.(4408-4410)GAG>AAG	p.E1470K		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1566	1-2.|2 X 96 AA approximate tandem repeats.		Missing.		cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GGGCTTGGAGGAGGGGCTCGT	0.478													A	214816089	A	A	214816089	3	1	158	1	0	0	0	0	1	0	0	0	3231	1175	41	3	4450	3	CENPF	1	214816089	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	35295711	214816089	34434532	6	11153											
EPRS	2058	broad.mit.edu	37	chr1	220154727	220154727	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtgaatacctaccaccacaTtgcaccactgattgagcttg	8	12	0	3			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr1:220154727T>C	uc001hly.1	-	24	3716	c.3446A>G	c.(3445-3447)AAT>AGT	p.N1149S		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1149	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TACCACCACATTGCACCACTG	0.358													C	220154727	C	C	220154727	3	2	158	1	0	0	0	0	1	0	0	0	5191	1493	52	4	1128	4	EPRS	1	220154727	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08	5338638	220154727	29095894	7	11154											
TGFA	7039	broad.mit.edu	37	chr2	70742029	70742029	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttctccaaggcctggcacGcagccaacacaatacctgtt	8	14	1	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr2:70742029G>A	uc002sgs.3	-	2	262	c.56C>T	c.(55-57)GCG>GTG	p.A19V	TGFA_uc010fdq.2_Missense_Mutation_p.A25V|TGFA_uc010fdr.2_Missense_Mutation_p.A25V|TGFA_uc002sgt.3_Missense_Mutation_p.A19V|TGFA_uc002sgu.2_Missense_Mutation_p.A19V|TGFA_uc002sgv.2_Missense_Mutation_p.A19V|TGFA_uc002sgw.2_Missense_Mutation_p.A19V	NM_003236	NP_003227	P01135	TGFA_HUMAN	transforming growth factor, alpha isoform 1	19					activation of MAPK activity|cell proliferation|positive regulation of cell division|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	cell surface|extracellular space|integral to membrane|plasma membrane	epidermal growth factor receptor binding|growth factor activity|MAP kinase kinase activity|signal transducer activity			prostate(1)	1						GGCCTGGCACGCAGCCAACAC	0.597													A	70742029	A	A	70742029	3	1	158	1	0	0	0	0	1	0	0	0	15812	1087	38	1	446	1	TGFA	2	70742029	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08		70742029	172457344	8	11155											
THNSL2	55258	broad.mit.edu	37	chr2	88472749	88472749	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctggctatgcacctgacgGgggcctctttatgcctgaag	12	12	2	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr2:88472749G>A	uc002ssz.3	+	2	233	c.80G>A	c.(79-81)GGG>GAG	p.G27E	THNSL2_uc002ssv.2_Intron|THNSL2_uc002ssw.3_Missense_Mutation_p.G27E|THNSL2_uc002ssx.3_Intron|THNSL2_uc002sta.3_Intron|THNSL2_uc002ssy.3_Missense_Mutation_p.G27E	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	27					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						GCACCTGACGGGGGCCTCTTT	0.607													A	88472749	A	A	88472749	3	1	158	1	0	0	0	0	1	0	0	0	15860	1232	43	3	82	3	THNSL2	2	88472749	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	17730720	88472749	154726624	9	11156											
YSK4	80122	broad.mit.edu	37	chr2	135745654	135745654	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taactagggctcccggaggcTcgtttgatgggctgagctca	14	10	1	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr2:135745654T>G	uc002tue.1	-	7	819	c.788A>C	c.(787-789)GAG>GCG	p.E263A	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.E150A|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_5'UTR|YSK4_uc002tui.3_Missense_Mutation_p.E280A	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	263							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCCCGGAGGCTCGTTTGATGG	0.443													G	135745654	G	G	135745654	3	3	158	1	0	0	0	0	1	0	0	0	17492	1551	54	5	3214	5	YSK4	2	135745654	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08	47272905	135745654	107453719	10	11157											
ARHGAP15	55843	broad.mit.edu	37	chr2	143913090	143913090	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacaaattctgatacttccGtggaaacactgaattctacc	5	11	2	2	rs140767178		TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr2:143913090G>A	uc002tvm.3	+	2	182	c.31G>A	c.(31-33)GTG>ATG	p.V11M	ARHGAP15_uc010zbl.1_Missense_Mutation_p.V11M	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	11					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TGATACTTCCGTGGAAACACT	0.363													A	143913090	A	A	143913090	3	1	158	1	0	0	0	0	1	0	0	0	866	1145	40	1	33	1	ARHGAP15	2	143913090	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	8167436	143913090	99286283	11	11158											
SCN7A	6332	broad.mit.edu	37	chr2	167262458	167262458	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agccatggggaggtccaaagCaatgagctggcccttgtttg	14	9	0	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr2:167262458C>A	uc002udu.1	-	25	4808	c.4681G>T	c.(4681-4683)GCT>TCT	p.A1561S		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1561					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AGGTCCAAAGCAATGAGCTGG	0.453													A	167262458	A	A	167262458	3	1	158	1	0	0	0	0	1	0	0	0	13923	710	25	5	371	5	SCN7A	2	167262458	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	23349368	167262458	75936915	12	11159											
INPP5D	3635	broad.mit.edu	37	chr2	234106832	234106832	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccaccaatgcccctgcacGtgaagcagaccttgtcccct	9	17	0	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr2:234106832G>A	uc010zmo.1	+	24	2938	c.2785G>A	c.(2785-2787)GTG>ATG	p.V929M	INPP5D_uc010zmp.1_Missense_Mutation_p.V928M	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	929	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GCCCCTGCACGTGAAGCAGAC	0.647													A	234106832	A	A	234106832	3	1	158	1	0	0	0	0	1	0	0	0	7756	1145	40	1	2391	1	INPP5D	2	234106832	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	66844374	234106832	9092541	13	11160											
UGT1A1	54658	broad.mit.edu	37	chr2	234669017	234669017	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccagtggtgtcccatgctggGaagatactgttgatcccagt	12	10	0	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr2:234669017G>A	uc002vvb.2	+	1	99	c.84G>A	c.(82-84)GGG>GGA	p.G28G	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Silent_p.G28G	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	28					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CCCATGCTGGGAAGATACTGT	0.617													A	234669017	A	A	234669017	2	1	158	1	0	0	0	0	0	0	0	1	16941	1161	41	3		3	UGT1A1	2	234669017	Silent	SNP	G	TCGA-19-2625-01A-01D-1495-08	562185	234669017	8530356	14	11161											
PPP1R7	5510	broad.mit.edu	37	chr2	242105797	242105797	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtctgcagaacctggtgaacCtgcgggagctgtaccttagc	13	11	1	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr2:242105797C>G	uc002wat.1	+	8	775	c.760C>G	c.(760-762)CTG>GTG	p.L254V	PPP1R7_uc010fzm.1_Missense_Mutation_p.L238V|PPP1R7_uc002war.2_Missense_Mutation_p.L248V|PPP1R7_uc002was.2_Missense_Mutation_p.L254V|PPP1R7_uc002wau.1_Missense_Mutation_p.L211V|PPP1R7_uc002wav.1_Missense_Mutation_p.L180V	NM_002712	NP_002703	Q15435	PP1R7_HUMAN	protein phosphatase 1, regulatory subunit 7	254	LRR 9.					cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			ovary(3)	3		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)		CCTGGTGAACCTGCGGGAGCT	0.552													G	242105797	G	G	242105797	3	3	158	1	0	0	0	0	1	0	0	0	12376	680	24	5	790	5	PPP1R7	2	242105797	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	7436780	242105797	1093576	15	11162											
CAND2	23066	broad.mit.edu	37	chr3	12856870	12856870	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaacacagcccccgaagggaTggctggaggccatggaggaa	15	10	0	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr3:12856870T>A	uc003bxk.2	+	8	1286	c.1237T>A	c.(1237-1239)TGG>AGG	p.W413R	CAND2_uc003bxj.2_Missense_Mutation_p.W320R	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	413					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						CCCGAAGGGATGGCTGGAGGC	0.607													A	12856870	A	A	12856870	3	1	158	1	0	0	0	0	1	0	0	0	2616	1464	51	5	1267	5	CAND2	3	12856870	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08		12856870	185165560	16	11163											
LRIG1	26018	broad.mit.edu	37	chr3	66455660	66455660	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agccctgagaaggcgccgctCgtgtcctctattgtgcccga	12	14	1	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr3:66455660C>T	uc003dmx.2	-	9	1136	c.1122G>A	c.(1120-1122)ACG>ACA	p.T374T	LRIG1_uc011bfu.1_5'Flank|LRIG1_uc003dmw.2_Silent_p.T40T|LRIG1_uc010hnz.2_Silent_p.T114T|LRIG1_uc010hoa.2_Silent_p.T374T	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	374	Extracellular (Potential).|LRR 13.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		AGGCGCCGCTCGTGTCCTCTA	0.612													T	66455660	T	T	66455660	2	4	158	1	0	0	0	0	0	0	0	1	8944	871	31	2		2	LRIG1	3	66455660	Silent	SNP	C	TCGA-19-2625-01A-01D-1495-08	53598790	66455660	131566770	17	11164											
GPR15	2838	broad.mit.edu	37	chr3	98251885	98251885	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actgagacatcagatagtcaCctcactaaggctctctccac	6	14	4	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr3:98251885C>G	uc011bgy.1	+	1	1008	c.1008C>G	c.(1006-1008)CAC>CAG	p.H336Q		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	336	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		CAGATAGTCACCTCACTAAGG	0.483													G	98251885	G	G	98251885	3	3	158	1	0	0	0	0	1	0	0	0	6655	506	18	5	1010	5	GPR15	3	98251885	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	31796225	98251885	99770545	18	11165											
PDLIM5	10611	broad.mit.edu	37	chr4	95575673	95575673	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaattcaactgcgctcactGcaaaaatacaatggcctaca	6	11	2	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr4:95575673G>A	uc003hti.2	+	10	1497	c.1346G>A	c.(1345-1347)TGC>TAC	p.C449Y	PDLIM5_uc011cdx.1_Missense_Mutation_p.C346Y|PDLIM5_uc003hth.2_Missense_Mutation_p.C340Y|PDLIM5_uc003htj.2_Missense_Mutation_p.C124Y|PDLIM5_uc003htk.2_Missense_Mutation_p.C478Y|PDLIM5_uc011cdy.1_Missense_Mutation_p.C327Y|PDLIM5_uc003htl.2_Missense_Mutation_p.C124Y	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	449	LIM zinc-binding 1.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		TGCGCTCACTGCAAAAATACA	0.448													A	95575673	A	A	95575673	3	1	158	1	0	0	0	0	1	0	0	0	11683	1319	46	3	1540	3	PDLIM5	4	95575673	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08		95575673	95578603	19	11166											
ODZ3	55714	broad.mit.edu	37	chr4	183710311	183710311	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagacagaaaagatctatgaCgaccaccgtaaatttctact	6	9	2	4			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr4:183710311C>T	uc003ivd.1	+	24	5407	c.5370C>T	c.(5368-5370)GAC>GAT	p.D1790D		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1790	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AGATCTATGACGACCACCGTA	0.448													T	183710311	T	T	183710311	2	4	158	1	0	0	0	0	0	0	0	1	10836	535	19	1		1	ODZ3	4	183710311	Silent	SNP	C	TCGA-19-2625-01A-01D-1495-08	88134638	183710311	7443965	20	11167											
SLC12A7	10723	broad.mit.edu	37	chr5	1085433	1085433	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgcaggccaggaagaccagCgccagcttgttgacatactt	11	12	0	2	rs112522540		TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr5:1085433C>T	uc003jbu.2	-	7	897	c.831G>A	c.(829-831)GCG>GCA	p.A277A		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	277	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GGAAGACCAGCGCCAGCTTGT	0.637													T	1085433	T	T	1085433	2	4	158	1	0	0	0	0	0	0	0	1	14388	755	27	1		1	SLC12A7	5	1085433	Silent	SNP	C	TCGA-19-2625-01A-01D-1495-08		1085433	179829827	21	11168											
JMY	133746	broad.mit.edu	37	chr5	78533329	78533329	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agcaggaaatcgacactctgTgttaccagctccaggtctac	9	12	2	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr5:78533329T>C	uc003kfx.3	+	1	1376	c.856T>C	c.(856-858)TGT>CGT	p.C286R		NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	286					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		CGACACTCTGTGTTACCAGCT	0.632													C	78533329	C	C	78533329	3	2	158	1	0	0	0	0	1	0	0	0	7957	1696	59	4	858	4	JMY	5	78533329	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08	77447896	78533329	102381931	22	11169											
EGR1	1958	broad.mit.edu	37	chr5	137801566	137801568	+	In_Frame_Del	DEL	TGC	-	-													ccctaagctggaggagatgaTgctgctgagcaacggggctc							TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr5:137801566_137801568delTGC	uc003ldb.1	+	1	386_388	c.116_118delTGC	c.(115-120)ATGCTG>ATG	p.L41del	EGR1_uc011cyu.1_In_Frame_Del_p.L41del	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	41					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GAGGAGATGATGCTGCTGAGCAA	0.488													-	137801568	-	-	137801566	7	5	158	1	0	1	0	1	0	0	0	0	4971	1464	51	0	118	0	EGR1	5	137801566	In_Frame_Del	DEL	TGC	TCGA-19-2625-01A-01D-1495-08	59268237	137801566	43113694	23	11170											
MED7	9443	broad.mit.edu	37	chr5	156566183	156566183	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctaaaaggtccaagaaattaAtaaggatagacatattaagt	7	4	0	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr5:156566183A>G	uc010jik.2	-	2	652	c.260T>C	c.(259-261)ATT>ACT	p.I87T	MED7_uc003lwm.3_Missense_Mutation_p.I87T	NM_001100816	NP_001094286	O43513	MED7_HUMAN	mediator complex subunit 7	87					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity				0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAAGAAATTAATAAGGATAGA	0.378													G	156566183	G	G	156566183	3	3	158	1	0	0	0	0	1	0	0	0	9452	101	4	4	445	4	MED7	5	156566183	Missense_Mutation	SNP	A	TCGA-19-2625-01A-01D-1495-08	18764617	156566183	24349077	24	11171											
SQSTM1	8878	broad.mit.edu	37	chr5	179260112	179260114	+	In_Frame_Del	DEL	GAG	-	-													ctccagagagttccagcacaGaggagaagagcagctcacag							TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr5:179260112_179260114delGAG	uc003mkw.3	+	6	930_932	c.835_837delGAG	c.(835-837)GAGdel	p.E280del	SQSTM1_uc011dgr.1_In_Frame_Del_p.E196del|SQSTM1_uc011dgs.1_In_Frame_Del_p.E196del|SQSTM1_uc003mkv.3_In_Frame_Del_p.E280del|SQSTM1_uc003mkx.2_In_Frame_Del_p.E196del	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	280	Interaction with NTRK1 (By similarity).|Ser-rich.				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCAGCACAGAGGAGAAGAGCA	0.596									Paget_Disease_of_Bone				-	179260114	-	-	179260112	7	5	158	1	0	1	0	1	0	0	0	0	15129	943	33	0	857	0	SQSTM1	5	179260112	In_Frame_Del	DEL	GAG	TCGA-19-2625-01A-01D-1495-08	22693929	179260112	1655148	25	11172											
HSP90AB1	3326	broad.mit.edu	37	chr6	44217828	44217828	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cagacagagtacctagaagaGaggcgggtcaaagaagtagt	14	6	1	5			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr6:44217828G>C	uc003oxa.1	+	5	669	c.585G>C	c.(583-585)GAG>GAC	p.E195D	HSP90AB1_uc011dvr.1_Missense_Mutation_p.E185D|HSP90AB1_uc003oxb.1_Missense_Mutation_p.E195D|HSP90AB1_uc011dvs.1_Missense_Mutation_p.E15D|HSP90AB1_uc003oxc.1_5'UTR	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	195					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACCTAGAAGAGAGGCGGGTCA	0.428													C	44217828	C	C	44217828	3	2	158	1	0	0	0	0	1	0	0	0	7402	933	33	5	599	5	HSP90AB1	6	44217828	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08		44217828	126897239	26	11173											
GSTA4	2941	broad.mit.edu	37	chr6	52850376	52850376	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacttgttggaacagcaggtGgttacctgagaatggaagcc	13	8	0	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr6:52850376G>A	uc003pbc.2	-	3	209	c.145C>T	c.(145-147)CAC>TAC	p.H49Y	GSTA4_uc003pbd.2_5'UTR|GSTA4_uc003pbe.2_Intron|GSTA4_uc003pbf.2_Missense_Mutation_p.H49Y	NM_001512	NP_001503	O15217	GSTA4_HUMAN	glutathione S-transferase alpha 4	49	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity				0	Lung NSC(77;0.103)				Glutathione(DB00143)	AACAGCAGGTGGTTACCTGAG	0.458													A	52850376	A	A	52850376	3	1	158	1	0	0	0	0	1	0	0	0	6833	1348	47	3	539	3	GSTA4	6	52850376	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	8632548	52850376	118264691	27	11174											
PHF3	23469	broad.mit.edu	37	chr6	64416078	64416078	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	attctttgaggaggagaaacAggagtctccaaagtcaacgt	11	7	3	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr6:64416078A>T	uc003pep.1	+	11	3553	c.3527A>T	c.(3526-3528)CAG>CTG	p.Q1176L	PHF3_uc010kah.1_Missense_Mutation_p.Q990L|PHF3_uc003pen.2_Missense_Mutation_p.Q1088L|PHF3_uc011dxs.1_Missense_Mutation_p.Q445L	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1176					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			GAGGAGAAACAGGAGTCTCCA	0.378													T	64416078	T	T	64416078	3	4	158	1	0	0	0	0	1	0	0	0	11836	188	7	5	3569	5	PHF3	6	64416078	Missense_Mutation	SNP	A	TCGA-19-2625-01A-01D-1495-08	11565702	64416078	106698989	28	11175											
EZR	7430	broad.mit.edu	37	chr6	159210403	159210403	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtggtaactcggacattgaTctgaaaaacagaatgaaaca	10	6	1	4			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr6:159210403T>C	uc003qrt.3	-	2	228	c.13A>G	c.(13-15)ATC>GTC	p.I5V	EZR_uc011efs.1_Missense_Mutation_p.I5V|EZR_uc003qru.3_Missense_Mutation_p.I5V	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	5	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		CGGACATTGATCTGAAAAACA	0.428													C	159210403	C	C	159210403	3	2	158	1	0	0	0	0	1	0	0	0	5335	1449	50	4	1795	4	EZR	6	159210403	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08	94794325	159210403	11904664	29	11176											
MLLT4	4301	broad.mit.edu	37	chr6	168343837	168343837	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaagataaactaggaatctAtgtgaagtcggttgtgaaag	11	4	2	3			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr6:168343837A>G	uc003qwd.2	+	23	3246	c.3104A>G	c.(3103-3105)TAT>TGT	p.Y1035C	MLLT4_uc003qwb.1_Missense_Mutation_p.Y1020C|MLLT4_uc003qwc.1_Missense_Mutation_p.Y1036C|MLLT4_uc003qwg.1_Missense_Mutation_p.Y345C	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1036	PDZ.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CTAGGAATCTATGTGAAGTCG	0.373			T	MLL	AL								G	168343837	G	G	168343837	3	3	158	1	0	0	0	0	1	0	0	0	9629	449	16	4	3197	4	MLLT4	6	168343837	Missense_Mutation	SNP	A	TCGA-19-2625-01A-01D-1495-08	9133434	168343837	2771230	30	11177											
EGFR	1956	broad.mit.edu	37	chr7	55249002	55249003	+	In_Frame_Ins	INS	-	CAGCGTGGA	CAGCGTGGA													caggaagcctacgtgatggcINScagcgtggacaacccccacg							TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr7:55249002_55249003insCAGCGTGGA	uc003tqk.2	+	20	2546_2547	c.2300_2301insCAGCGTGGA	c.(2299-2301)GCC>GCCAGCGTGGAC	p.770_771insSVD	EGFR_uc010kzg.1_In_Frame_Ins_p.725_726insSVD|EGFR_uc011kco.1_In_Frame_Ins_p.717_718insSVD|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	770_771	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.D770_N771insSVD(21)|p.V769_D770insASV(20)|p.D770_N771insG(6)|p.D770>GY(3)|p.V769_D770insMASVD(2)|p.A767V(2)|p.V769_D770insGVV(2)|p.V769_D770insCV(1)|p.D770N(1)|p.D770_N771insGD(1)|p.D770_N771>AGG(1)|p.D770_N771insGL(1)|p.D770fs*61(1)|p.D770_P772>ASVDNR(1)|p.D770_N771insD(1)|p.V769_D770insGSV(1)|p.D770_N771insN(1)|p.V769_D770insDNV(1)|p.D770_N771insAPW(1)|p.D770_N771insSVP(1)|p.D770_N771insSVQ(1)|p.D770>GF(1)|p.D770_N771insMATP(1)|p.D770_N771insDG(1)|p.D770_N771insNPH(1)|p.V769_D770insGV(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TACGTGATGGCCAGCGTGGACA	0.649		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			CAGCGTGGA	55249003	CAGCGTGGA	CAGCGTGGA	55249002	7	5	158	1	0	1	1	0	0	0	0	0	4967	739	26	0	2642	0	EGFR	7	55249002	In_Frame_Ins	INS	-	TCGA-19-2625-01A-01D-1495-08		55249002	103889661	31	11178											
CYP3A5	1577	broad.mit.edu	37	chr7	99277452	99277452	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttggacagttactcacagaTagaggagcaccaggctgaca	11	9	1	3			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr7:99277452T>C	uc003urq.2	-	1	155	c.68A>G	c.(67-69)TAT>TGT	p.Y23C	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urr.2_5'UTR|CYP3A5_uc011kiy.1_5'UTR|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron|CYP3A5_uc003urt.2_Missense_Mutation_p.Y23C	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	23					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	TACTCACAGATAGAGGAGCAC	0.488													C	99277452	C	C	99277452	3	2	158	1	0	0	0	0	1	0	0	0	4180	1406	49	4	1492	4	CYP3A5	7	99277452	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08	44028450	99277452	59861211	32	11179											
DOCK5	80005	broad.mit.edu	37	chr8	25232155	25232155	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctacacgcttctcttgcaCgctgagcttctgcaggtgaa	10	13	2	2	rs138488512		TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr8:25232155C>T	uc003xeg.2	+	37	3938	c.3801C>T	c.(3799-3801)CAC>CAT	p.H1267H	DOCK5_uc003xeh.1_Silent_p.H981H|PPP2R2A_uc003xek.2_Silent_p.H56H|DOCK5_uc003xei.2_Silent_p.H837H|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1267	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TTCTCTTGCACGCTGAGCTTC	0.463													T	25232155	T	T	25232155	2	4	158	1	0	0	0	0	0	0	0	1	4690	535	19	1		1	DOCK5	8	25232155	Silent	SNP	C	TCGA-19-2625-01A-01D-1495-08		25232155	121131867	33	11180											
TBC1D2	55357	broad.mit.edu	37	chr9	101017509	101017509	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcgaagatcccctcctcagcGtccgccttacagtcaaacac	6	17	2	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr9:101017509G>C	uc011lvb.1	-	1	495	c.315C>G	c.(313-315)GAC>GAG	p.D105E	TBC1D2_uc004ayq.2_Missense_Mutation_p.D105E|TBC1D2_uc004ayr.2_5'UTR|TBC1D2_uc004ayo.3_Missense_Mutation_p.D105E	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	105	PH.|Interaction with CADH1.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CCTCCTCAGCGTCCGCCTTAC	0.537													C	101017509	C	C	101017509	3	2	158	1	0	0	0	0	1	0	0	0	15605	1136	40	5	2490	5	TBC1D2	9	101017509	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08		101017509	40195922	34	11181											
ARMC4	55130	broad.mit.edu	37	chr10	28229643	28229643	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgcagctccacagggccagtGccccacagcgagccacttcc	10	18	0	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr10:28229643G>T	uc009xky.2	-	13	1933	c.1835C>A	c.(1834-1836)GCA>GAA	p.A612E	ARMC4_uc010qds.1_Missense_Mutation_p.A137E|ARMC4_uc010qdt.1_Missense_Mutation_p.A304E|ARMC4_uc001itz.2_Missense_Mutation_p.A612E|ARMC4_uc010qdu.1_Missense_Mutation_p.A304E	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	612							binding			ovary(4)|skin(2)	6						CAGGGCCAGTGCCCCACAGCG	0.517													T	28229643	T	T	28229643	3	4	158	1	0	0	0	0	1	0	0	0	953	1319	46	5	1331	5	ARMC4	10	28229643	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08		28229643	107305104	35	11182											
PTEN	5728	broad.mit.edu	37	chr10	89685314	89685314	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccattacaagatatacaatcTgtaagtatgttttcttattt	4	6	2	1	rs121909226		TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr10:89685314T>A	uc001kfb.2	+	4	1240	c.209T>A	c.(208-210)CTT>CAT	p.L70H		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	70	Phosphatase tensin-type.		L -> P (in CD).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(4)|p.L70fs*7(4)|p.R55fs*1(4)|p.Y27_N212>Y(2)|p.Y27fs*1(2)|p.L70F(1)|p.L70P(1)|p.R55_L70>S(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ATATACAATCTGTAAGTATGT	0.279		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89685314	A	A	89685314	3	1	158	1	0	0	0	0	1	0	0	0	12738	1594	55	5	219	5	PTEN	10	89685314	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08	61455671	89685314	45849433	36	11183											
CDHR5	53841	broad.mit.edu	37	chr11	618758	618758	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcctctggggtctgtgctgTgcccccaccgggtgtggctg	16	13	2	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr11:618758T>C	uc001lqj.2	-	13	1906	c.1801A>G	c.(1801-1803)ACA>GCA	p.T601A	IRF7_uc001lqh.2_5'Flank|IRF7_uc001lqi.2_5'Flank|IRF7_uc010qwh.1_5'Flank|CDHR5_uc001lqk.2_Intron|CDHR5_uc009ycc.2_Missense_Mutation_p.T435A|CDHR5_uc009ycd.2_Missense_Mutation_p.T595A|CDHR5_uc001lql.2_Missense_Mutation_p.T601A	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	601	4 X 31 AA approximate tandem repeats.|2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						GTCTGTGCTGTGCCCCCACCG	0.667													C	618758	C	C	618758	3	2	158	1	0	0	0	0	1	0	0	0	3122	1696	59	4	748	4	CDHR5	11	618758	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08		618758	134387758	37	11184											
CD3E	916	broad.mit.edu	37	chr11	118184559	118184559	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaggccaagcctgtgacaCgaggagcgggtgctggcggc	17	12	0	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr11:118184559C>T	uc001psq.3	+	7	746	c.490C>T	c.(490-492)CGA>TGA	p.R164*		NM_000733	NP_000724	P07766	CD3E_HUMAN	CD3E antigen, epsilon polypeptide precursor	164	Cytoplasmic (Potential).				G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			ovary(2)	2	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	GCCTGTGACACGAGGAGCGGG	0.597													T	118184559	T	T	118184559	4	4	158	1	0	0	0	0	0	1	0	0	3011	528	19	1	512	1	CD3E	11	118184559	Nonsense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	117565801	118184559	16821957	38	11185											
ABCC9	10060	broad.mit.edu	37	chr12	22065805	22065805	+	Splice_Site	DEL	C	-	-													tgaaaatcaccaggaacttaCtccagttgtgttatttgtcc							TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr12:22065805delC	uc001rfi.1	-	6	1031	c.1011_splice	c.e6+1	p.G337_splice	ABCC9_uc001rfh.2_Splice_Site_p.G337_splice|ABCC9_uc001rfj.1_Splice_Site_p.G337_splice	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9						defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGGAACTTACTCCAGTTGTG	0.353													-	22065805	-	-	22065805	8	5	158	1	0	1	0	1	0	0	1	0	59	579	20	0	3911	0	ABCC9	12	22065805	Splice_Site	DEL	C	TCGA-19-2625-01A-01D-1495-08		22065805	111786090	39	11186											
WNT10B	7480	broad.mit.edu	37	chr12	49361974	49361974	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cagcagtttggccctcagccGatcctgctcaccactgccct	8	18	2	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr12:49361974G>T	uc001rss.2	-	4	812	c.466C>A	c.(466-468)CGG>AGG	p.R156R	WNT10B_uc001rst.2_Silent_p.R156R	NM_003394	NP_003385	O00744	WN10B_HUMAN	wingless-type MMTV integration site family,	156					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity	p.R156Q(1)		skin(4)|lung(3)	7						GCCCTCAGCCGATCCTGCTCA	0.532													T	49361974	T	T	49361974	2	4	158	1	0	0	0	0	0	0	0	1	17380	1057	37	5		5	WNT10B	12	49361974	Silent	SNP	G	TCGA-19-2625-01A-01D-1495-08	27296169	49361974	84489921	40	11187											
EP400	57634	broad.mit.edu	37	chr12	132471269	132471269	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caggggtggtggcatctgccCccaccaaaccacagagtcct	11	15	1	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr12:132471269C>A	uc001ujn.2	+	5	2175	c.2140C>A	c.(2140-2142)CCC>ACC	p.P714T	EP400_uc001ujl.2_Missense_Mutation_p.P713T|EP400_uc001ujm.2_Missense_Mutation_p.P714T|EP400_uc001ujj.1_Missense_Mutation_p.P677T|EP400_uc001ujk.2_Missense_Mutation_p.P750T	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	750					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGCATCTGCCCCCACCAAACC	0.532													A	132471269	A	A	132471269	3	1	158	1	0	0	0	0	1	0	0	0	5149	623	22	5	2155	5	EP400	12	132471269	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	83109295	132471269	1380626	41	11188											
RB1	5925	broad.mit.edu	37	chr13	48919325	48919332	+	Frame_Shift_Del	DEL	AAATTGGA	-	-													tattgtttgcactcttcagcAaattggaaaggtaaagtaaa					rs66624868		TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr13:48919325_48919332delAAATTGGA	uc001vcb.2	+	4	656_663	c.490_497delAAATTGGA	c.(490-498)AAATTGGAAfs	p.K164fs	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	164_166					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)|p.E166*(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACTCTTCAGCAAATTGGAAAGGTAAAGT	0.284		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			-	48919332	-	-	48919325	7	5	158	1	0	1	0	1	0	0	0	0	13098	131	5	0	504	0	RB1	13	48919325	Frame_Shift_Del	DEL	AAATTGGA	TCGA-19-2625-01A-01D-1495-08		48919325	66250553	42	11189											
KIAA0317	9870	broad.mit.edu	37	chr14	75149998	75149998	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaaaggaaaaaagaacctaCcaggttgaaaaattttgtag	9	4	0	3			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr14:75149998C>T	uc001xqb.2	-	5	986	c.481_splice	c.e5+1	p.G161_splice	KIAA0317_uc010tut.1_Splice_Site|KIAA0317_uc001xqc.2_Splice_Site_p.G161_splice	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		aaagaaCCTACCAGGTTGAAA	0.239													T	75149998	T	T	75149998	5	4	158	1	0	0	0	0	0	0	1	0	8167	521	18	3	2053	3	KIAA0317	14	75149998	Splice_Site	SNP	C	TCGA-19-2625-01A-01D-1495-08		75149998	32199542	43	11190											
PGP	283871	broad.mit.edu	37	chr16	2263929	2263929	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caggcggtctcccaccatgaCggtgcgctcggggttgatgc	15	13	1	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr16:2263929C>A	uc002cpk.1	-	2	810	c.766G>T	c.(766-768)GTC>TTC	p.V256F	C16orf79_uc002cpi.1_5'Flank|C16orf79_uc010bsh.2_5'Flank|PGP_uc010uvz.1_RNA	NM_001042371	NP_001035830	A6NDG6	PGP_HUMAN	phosphoglycolate phosphatase	256					carbohydrate metabolic process		phosphoglycolate phosphatase activity			skin(1)	1						CCCACCATGACGGTGCGCTCG	0.632													A	2263929	A	A	2263929	3	1	158	1	0	0	0	0	1	0	0	0	11802	536	19	5	203	5	PGP	16	2263929	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08		2263929	88090824	44	11191											
CDH5	1003	broad.mit.edu	37	chr16	66426078	66426078	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagcaatacagcttcatcGtcgaggccacagaccccacc	7	17	1	1	rs147523967		TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr16:66426078G>A	uc002eom.3	+	7	1165	c.1009G>A	c.(1009-1011)GTC>ATC	p.V337I	CDH5_uc002eon.1_Missense_Mutation_p.V337I	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	337	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CAGCTTCATCGTCGAGGCCAC	0.433													A	66426078	A	A	66426078	3	1	158	1	0	0	0	0	1	0	0	0	3113	1145	40	1	1031	1	CDH5	16	66426078	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	64162149	66426078	23928675	45	11192											
PMFBP1	83449	broad.mit.edu	37	chr16	72153835	72153835	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccttccagcccaaggtgccGcacactttctccctctgtgt	7	18	2	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr16:72153835G>A	uc002fcc.3	-	20	3109	c.2937C>T	c.(2935-2937)TGC>TGT	p.C979C	PMFBP1_uc002fcd.2_Silent_p.C974C|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Silent_p.C849C	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	979										ovary(2)	2		Ovarian(137;0.179)				CCAAGGTGCCGCACACTTTCT	0.557													A	72153835	A	A	72153835	2	1	158	1	0	0	0	0	0	0	0	1	12134	1079	38	1		1	PMFBP1	16	72153835	Silent	SNP	G	TCGA-19-2625-01A-01D-1495-08	5727757	72153835	18200918	46	11193											
KARS	3735	broad.mit.edu	37	chr16	75669879	75669879	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacagcagtgtgatctcataCggaatgatgctcagctcacc	10	11	3	2	rs143003475		TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr16:75669879C>T	uc002feq.2	-	5	648	c.600G>A	c.(598-600)CCG>CCA	p.P200P	KARS_uc002fer.2_Silent_p.P228P|KARS_uc002fes.2_Silent_p.P44P|KARS_uc010cgz.2_Silent_p.P44P	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	200					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	TGATCTCATACGGAATGATGC	0.448													T	75669879	T	T	75669879	2	4	158	1	0	0	0	0	0	0	0	1	7980	523	19	1		1	KARS	16	75669879	Silent	SNP	C	TCGA-19-2625-01A-01D-1495-08	3516044	75669879	14684874	47	11194											
OR1G1	8390	broad.mit.edu	37	chr17	3030338	3030338	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtgggatctcatggtttgCgcagaaggacaggctgttca	15	7	2	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr17:3030338C>T	uc002fvc.1	-	1	508	c.508G>A	c.(508-510)GCA>ACA	p.A170T		NM_003555	NP_003546	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCATGGTTTGCGCAGAAGGAC	0.532													T	3030338	T	T	3030338	3	4	158	1	0	0	0	0	1	0	0	0	10957	768	27	1	437	1	OR1G1	17	3030338	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08		3030338	78164872	48	11195											
TP53	7157	broad.mit.edu	37	chr17	7577568	7577568	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcccatgcaggaactgttaCacatgtagttgtagtggatg	12	8	0	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr17:7577568C>T	uc002gim.2	-	7	907	c.713G>A	c.(712-714)TGT>TAT	p.C238Y	TP53_uc002gig.1_Missense_Mutation_p.C238Y|TP53_uc002gih.2_Missense_Mutation_p.C238Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106Y|TP53_uc010cng.1_Missense_Mutation_p.C106Y|TP53_uc002gii.1_Missense_Mutation_p.C106Y|TP53_uc010cnh.1_Missense_Mutation_p.C238Y|TP53_uc010cni.1_Missense_Mutation_p.C238Y|TP53_uc002gij.2_Missense_Mutation_p.C238Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145Y|TP53_uc002gio.2_Missense_Mutation_p.C106Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577568	T	T	7577568	3	4	158	1	0	0	0	0	1	0	0	0	16378	478	17	3	577	3	TP53	17	7577568	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	4547230	7577568	73617642	49	11196											
TP53	7157	broad.mit.edu	37	chr17	7578235	7578235	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagtgtttctgtcatccaaaTactccacacgcaaatttcct	4	12	2	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr17:7578235T>C	uc002gim.2	-	6	808	c.614A>G	c.(613-615)TAT>TGT	p.Y205C	TP53_uc002gig.1_Missense_Mutation_p.Y205C|TP53_uc002gih.2_Missense_Mutation_p.Y205C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y73C|TP53_uc010cng.1_Missense_Mutation_p.Y73C|TP53_uc002gii.1_Missense_Mutation_p.Y73C|TP53_uc010cnh.1_Missense_Mutation_p.Y205C|TP53_uc010cni.1_Missense_Mutation_p.Y205C|TP53_uc002gij.2_Missense_Mutation_p.Y205C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y112C|TP53_uc002gio.2_Missense_Mutation_p.Y73C|TP53_uc010vug.1_Missense_Mutation_p.Y166C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	205	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> C (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(55)|p.Y205D(13)|p.Y205S(11)|p.Y205F(8)|p.0?(7)|p.Y205H(5)|p.Y205*(4)|p.Y205N(2)|p.K164_P219del(1)|p.Y205fs*42(1)|p.Y112C(1)|p.Y205fs*43(1)|p.E204fs*39(1)|p.Y73C(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATCCAAATACTCCACACG	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7578235	C	C	7578235	3	2	158	1	0	0	0	0	1	0	0	0	16378	1406	49	4	680	4	TP53	17	7578235	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08	667	7578235	73616975	50	11197											
MYH2	4620	broad.mit.edu	37	chr17	10432765	10432765	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agccctttctaggtccatgcGaagtttcttttcttgctcca	7	12	3	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr17:10432765G>A	uc010coi.2	-	25	3279	c.3151C>T	c.(3151-3153)CGC>TGC	p.R1051C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1051C|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1051	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AGGTCCATGCGAAGTTTCTTT	0.383													A	10432765	A	A	10432765	3	1	158	1	0	0	0	0	1	0	0	0	10035	1058	37	2	2738	2	MYH2	17	10432765	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	2854530	10432765	70762445	51	11198											
MUC16	94025	broad.mit.edu	37	chr19	9068025	9068025	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atccatgagtcatagctgagTgggtccctgcctgtgaggtt	13	9	1	3			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr19:9068025T>C	uc002mkp.2	-	3	19625	c.19421A>G	c.(19420-19422)CAC>CGC	p.H6474R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6476	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CATAGCTGAGTGGGTCCCTGC	0.488													C	9068025	C	C	9068025	3	2	158	1	0	0	0	0	1	0	0	0	9973	1696	59	4	24430	4	MUC16	19	9068025	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08		9068025	50060958	52	11199											
LDLR	3949	broad.mit.edu	37	chr19	11224247	11224247	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcccacggcgtctcttcctaTgacaccgtcatcagcagaga	9	15	3	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr19:11224247T>C	uc002mqk.3	+	10	1563	c.1395T>C	c.(1393-1395)TAT>TAC	p.Y465Y	LDLR_uc010xlk.1_Silent_p.Y465Y|LDLR_uc010xll.1_Silent_p.Y424Y|LDLR_uc010xlm.1_Silent_p.Y318Y|LDLR_uc010xln.1_Silent_p.Y338Y|LDLR_uc010xlo.1_Silent_p.Y297Y	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	465	LDL-receptor class B 2.|Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	TCTCTTCCTATGACACCGTCA	0.622													C	11224247	C	C	11224247	2	2	158	1	0	0	0	0	0	0	0	1	8704	1471	51	4		4	LDLR	19	11224247	Silent	SNP	T	TCGA-19-2625-01A-01D-1495-08	2156222	11224247	47904736	53	11200											
PRPF31	26121	broad.mit.edu	37	chr19	54621969	54621969	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acagtttgctgagattatgaTgaagattgaggagtatatca	11	3	1	5	rs145505952	byFrequency	TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr19:54621969T>C	uc002qdh.2	+	3	590	c.194T>C	c.(193-195)ATG>ACG	p.M65T	TFPT_uc010yej.1_5'Flank|TFPT_uc010erd.2_5'Flank|PRPF31_uc010yek.1_Missense_Mutation_p.M65T	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	65					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GAGATTATGATGAAGATTGAG	0.502													C	54621969	C	C	54621969	3	2	158	1	0	0	0	0	1	0	0	0	12566	1464	51	4	200	4	PRPF31	19	54621969	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08	43397722	54621969	4507014	54	11201											
C20orf72	92667	broad.mit.edu	37	chr20	17950509	17950509	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaaacaaatctgaatgaagAtgaagttatttcagaccatt	7	5	2	5			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr20:17950509A>G	uc002wqh.2	+	2	89	c.7A>G	c.(7-9)ATG>GTG	p.M3V	C20orf72_uc010gco.2_RNA|C20orf72_uc010gcp.2_5'Flank|SNX5_uc002wqc.2_5'Flank|SNX5_uc002wqd.2_5'Flank|SNX5_uc002wqe.2_5'Flank|SNX5_uc010zrt.1_5'Flank|SNX5_uc010gcn.1_5'Flank	NM_052865	NP_443097	Q9BQP7	CT072_HUMAN	hypothetical protein LOC92667	3											0						CTGAATGAAGATGAAGTTATT	0.408													G	17950509	G	G	17950509	3	3	158	1	0	0	0	0	1	0	0	0	2118	333	12	4	9	4	C20orf72	20	17950509	Missense_Mutation	SNP	A	TCGA-19-2625-01A-01D-1495-08		17950509	45075011	55	11202											
WFDC8	90199	broad.mit.edu	37	chr20	44184401	44184401	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagttgttggcattcccttcGcagcccctgtatttgaaggg	11	10	0	1	rs150100809	byFrequency	TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr20:44184401G>A	uc002xow.2	-	4	463	c.384C>T	c.(382-384)TGC>TGT	p.C128C	WFDC8_uc002xox.2_Silent_p.C128C	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	128	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CATTCCCTTCGCAGCCCCTGT	0.468													A	44184401	A	A	44184401	2	1	158	1	0	0	0	0	0	0	0	1	17353	1079	38	1		1	WFDC8	20	44184401	Silent	SNP	G	TCGA-19-2625-01A-01D-1495-08	26233892	44184401	18841119	56	11203											
MC3R	4159	broad.mit.edu	37	chr20	54824279	54824279	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgactccatgatctgcatctCcctggtggcctccatctgca	8	16	3	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr20:54824279C>T	uc002xxb.2	+	1	492	c.380C>T	c.(379-381)TCC>TTC	p.S127F		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	164	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			ATCTGCATCTCCCTGGTGGCC	0.557													T	54824279	T	T	54824279	3	4	158	1	0	0	0	0	1	0	0	0	9365	855	30	3	382	3	MC3R	20	54824279	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	10639878	54824279	8201241	57	11204											
KRTAP24-1	643803	broad.mit.edu	37	chr21	31654689	31654689	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatataacataatggtgagaCgtagctgggtatgaagcaag	12	4	0	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr21:31654689C>T	uc002ynv.2	-	1	588	c.562G>A	c.(562-564)GTC>ATC	p.V188I		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	188						keratin filament	structural molecule activity				0						AATGGTGAGACGTAGCTGGGT	0.418													T	31654689	T	T	31654689	3	4	158	1	0	0	0	0	1	0	0	0	8542	536	19	1	206	1	KRTAP24-1	21	31654689	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08		31654689	16475206	58	11205											
PRDM15	63977	broad.mit.edu	37	chr21	43281674	43281674	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccccaactgtgcgcaccgGcatgtccttcctgcaacctg	8	17	0	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr21:43281674G>A	uc002yzq.1	-	7	1000	c.889C>T	c.(889-891)CCG>TCG	p.P297S	PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTGCGCACCGGCATGTCCTTC	0.463													A	43281674	A	A	43281674	3	1	158	1	0	0	0	0	1	0	0	0	12456	1203	42	3	3734	3	PRDM15	21	43281674	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	11626985	43281674	4848221	59	11206											
COL6A2	1292	broad.mit.edu	37	chr21	47546138	47546138	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcatcgatgacatggaggaCgtcctctgcccgggtgagcg	14	11	2	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr21:47546138C>T	uc002zia.1	+	26	2491	c.2409C>T	c.(2407-2409)GAC>GAT	p.D803D	COL6A2_uc002zhy.1_Silent_p.D803D|COL6A2_uc002zhz.1_Silent_p.D803D|COL6A2_uc002zib.1_Silent_p.D209D|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	803	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACATGGAGGACGTCCTCTGCC	0.647													T	47546138	T	T	47546138	2	4	158	1	0	0	0	0	0	0	0	1	3700	535	19	1		1	COL6A2	21	47546138	Silent	SNP	C	TCGA-19-2625-01A-01D-1495-08	4264464	47546138	583757	60	11207											
RIMBP3	85376	broad.mit.edu	37	chr22	20458331	20458331	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	catgggagccatacggagcaCccctttggtccccagaaggg	13	13	0	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr22:20458331C>G	uc002zsd.3	-	1	3456	c.2971G>C	c.(2971-2973)GTG>CTG	p.V991L		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			ATACGGAGCACCCCTTTGGTC	0.602													G	20458331	G	G	20458331	3	3	158	1	0	0	0	0	1	0	0	0	13364	507	18	5	1952	5	RIMBP3	22	20458331	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08		20458331	30846235	61	11208											
PISD	23761	broad.mit.edu	37	chr22	32017352	32017352	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaggtcctctgtgcacataCgcgggcccaggaacgactcc	12	15	1	0			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chr22:32017352C>T	uc003alm.3	-	5	672	c.665G>A	c.(664-666)CGT>CAT	p.R222H	PISD_uc003alk.2_Missense_Mutation_p.R188H|PISD_uc003all.2_Missense_Mutation_p.R187H|PISD_uc011alr.1_Missense_Mutation_p.R187H|PISD_uc003aln.3_Missense_Mutation_p.R222H	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	222					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)	TGTGCACATACGCGGGCCCAG	0.627											OREG0003530	type=REGULATORY REGION|Gene=PISD|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	T	32017352	T	T	32017352	3	4	158	1	0	0	0	0	1	0	0	0	11946	536	19	1	580	1	PISD	22	32017352	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	11559021	32017352	19287214	62	11209											
PLCXD1	55344	broad.mit.edu	37	chrX	215977	215977	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgtcagtgacgtcatcgcgcTcaatcagaagctgctgtggt	12	11	4	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chrX:215977T>C	uc004cpc.2	+	7	1259	c.947T>C	c.(946-948)CTC>CCC	p.L316P	PLCXD1_uc011mgx.1_RNA	NM_018390	NP_060860	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X	316					intracellular signal transduction|lipid metabolic process		phospholipase C activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTCATCGCGCTCAATCAGAAG	0.602													C	215977	C	C	215977	3	2	158	1	0	0	0	0	1	0	0	0	12041	1551	54	4	969	4	PLCXD1	23	215977	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08		215977	155054583	63	11210											
WWC3	55841	broad.mit.edu	37	chrX	10096087	10096087	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgagatgcagctgcgctgGcattccgtgcaggtgttcac	14	10	1	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chrX:10096087G>A	uc004csx.3	+	16	2364	c.2166G>A	c.(2164-2166)TGG>TGA	p.W722*	WWC3_uc010nds.2_Nonsense_Mutation_p.W386*|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	722										ovary(4)	4						AGCTGCGCTGGCATTCCGTGC	0.562													A	10096087	A	A	10096087	4	1	158	1	0	0	0	0	0	1	0	0	17410	1212	42	3	2224	3	WWC3	23	10096087	Nonsense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	9880110	10096087	145174473	64	11211											
PDHA1	5160	broad.mit.edu	37	chrX	19369427	19369427	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgtgggcctggaggccgGcatcaaccccacagaccatc	12	15	1	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chrX:19369427G>A	uc004czg.3	+	4	465	c.320G>A	c.(319-321)GGC>GAC	p.G107D	PDHA1_uc004czh.3_Missense_Mutation_p.G142D|PDHA1_uc011mjc.1_Missense_Mutation_p.G111D|PDHA1_uc011mjd.1_Missense_Mutation_p.G104D|PDHA1_uc010nfk.2_Missense_Mutation_p.G104D	NM_000284	NP_000275	P08559	ODPA_HUMAN	pyruvate dehydrogenase E1 alpha 1 precursor	107					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)	CTGGAGGCCGGCATCAACCCC	0.507													A	19369427	A	A	19369427	3	1	158	1	0	0	0	0	1	0	0	0	11664	1203	42	3	473	3	PDHA1	23	19369427	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	9273340	19369427	135901133	65	11212											
CCNB3	85417	broad.mit.edu	37	chrX	50051674	50051674	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aggaacccactattgaggatGaaacccttatcaataagtca	7	9	2	2			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chrX:50051674G>A	uc004dox.3	+	6	803	c.505G>A	c.(505-507)GAA>AAA	p.E169K	CCNB3_uc004doy.2_Missense_Mutation_p.E169K|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	169					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TATTGAGGATGAAACCCTTAT	0.433													A	50051674	A	A	50051674	3	1	158	1	0	0	0	0	1	0	0	0	2914	1291	45	3	519	3	CCNB3	23	50051674	Missense_Mutation	SNP	G	TCGA-19-2625-01A-01D-1495-08	30682247	50051674	105218886	66	11213											
TBX22	50945	broad.mit.edu	37	chrX	79281244	79281244	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcagctttgatcgcatgaaaCtcaccaacaatgagatggat	8	9	2	3			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chrX:79281244C>G	uc010nmg.1	+	5	735	c.601C>G	c.(601-603)CTC>GTC	p.L201V	TBX22_uc004edi.1_Missense_Mutation_p.L81V|TBX22_uc004edj.1_Missense_Mutation_p.L201V	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	201	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.L201I(1)		lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						TCGCATGAAACTCACCAACAA	0.537													G	79281244	G	G	79281244	3	3	158	1	0	0	0	0	1	0	0	0	15655	565	20	5	615	5	TBX22	23	79281244	Missense_Mutation	SNP	C	TCGA-19-2625-01A-01D-1495-08	29229570	79281244	75989316	67	11214											
ATP11C	286410	broad.mit.edu	37	chrX	138897124	138897124	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acttcattgtcagctctgtgTctcagacaatcctcatatcc	5	13	5	1			TCGA-19-2625-01A-01D-1495-08	TCGA-19-2625-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0833912-0cb6-4d2a-bd18-9fc211793b30	4445ea84-ab2f-4906-8ec0-47d0bd5ee63a	g.chrX:138897124T>A	uc004faz.2	-	5	447	c.348A>T	c.(346-348)AGA>AGT	p.R116S	ATP11C_uc004fba.2_Missense_Mutation_p.R116S	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	116	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					CAGCTCTGTGTCTCAGACAAT	0.303													A	138897124	A	A	138897124	3	1	158	1	0	0	0	0	1	0	0	0	1121	1664	58	5	3217	5	ATP11C	23	138897124	Missense_Mutation	SNP	T	TCGA-19-2625-01A-01D-1495-08	59615880	138897124	16373436	68	11215											
DNAJB4	11080	broad.mit.edu	37	chr1	78470832	78470832	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgcattttgggaattgagaAaggagcttcagatgaagata	12	3	1	4			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr1:78470832A>G	uc001dij.2	+	1	197	c.38A>G	c.(37-39)AAA>AGA	p.K13R	DNAJB4_uc010orn.1_Intron	NM_007034	NP_008965	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4	13	J.				protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding				0						GGAATTGAGAAAGGAGCTTCA	0.368													G	78470832	G	G	78470832	3	3	159	1	0	0	0	0	1	0	0	0	4622	14	1	4	40	4	DNAJB4	1	78470832	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08		78470832	170779789	1	11216											
ODF2L	57489	broad.mit.edu	37	chr1	86822223	86822223	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgtgaagcctccgttccgcCgccgtcaaggaatcgcagac	11	15	1	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr1:86822223C>T	uc001dll.1	-	14	1762	c.1422G>A	c.(1420-1422)GCG>GCA	p.A474A	ODF2L_uc001dlm.1_Silent_p.A445A|ODF2L_uc001dln.2_Silent_p.A445A|ODF2L_uc001dlo.2_Silent_p.A314A|ODF2L_uc001dlp.2_Intron|ODF2L_uc010osg.1_Intron	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	474	Potential.					centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		TCCGTTCCGCCGCCGTCAAGG	0.547													T	86822223	T	T	86822223	2	4	159	1	0	0	0	0	0	0	0	1	10828	639	23	2		2	ODF2L	1	86822223	Silent	SNP	C	TCGA-19-2629-01A-01D-1495-08	8351391	86822223	162428398	2	11217											
ZNF644	84146	broad.mit.edu	37	chr1	91403294	91403296	+	In_Frame_Del	DEL	CTT	-	-													ttcatttaagaaattcagccCttcttcttctgatgcagaca							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr1:91403294_91403296delCTT	uc001dnw.2	-	4	3576_3578	c.3434_3436delAAG	c.(3433-3438)GAAGGG>GGG	p.E1145del	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	1145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AAATTCAGCCCTTCTTCTTCTGA	0.365													-	91403296	-	-	91403294	7	5	159	1	0	1	0	1	0	0	0	0	18057	681	24	0	559	0	ZNF644	1	91403294	In_Frame_Del	DEL	CTT	TCGA-19-2629-01A-01D-1495-08	4581071	91403294	157847327	3	11218											
TMED5	50999	broad.mit.edu	37	chr1	93620253	93620256	+	Frame_Shift_Del	DEL	CAAA	-	-													tctacttttcctcttatcttCaaacagactcttcagcatat							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr1:93620253_93620256delCAAA	uc001dpn.2	-	4	1108_1111	c.661_664delTTTG	c.(661-666)TTTGAAfs	p.F221fs	TMED5_uc001dpo.2_3'UTR|TMED5_uc001dpp.2_RNA	NM_016040	NP_057124	Q9Y3A6	TMED5_HUMAN	transmembrane emp24 protein transport domain	221_222	Cytoplasmic (Potential).				transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane				ovary(1)	1		all_lung(203;0.0223)|Lung NSC(277;0.071)|Melanoma(281;0.147)|Glioma(108;0.188)		all cancers(265;0.00108)|GBM - Glioblastoma multiforme(16;0.00407)|Epithelial(280;0.0797)		CTCTTATCTTCAAACAGACTCTTC	0.348													-	93620256	-	-	93620253	7	5	159	1	0	1	0	1	0	0	0	0	16004	835	29	0	29	0	TMED5	1	93620253	Frame_Shift_Del	DEL	CAAA	TCGA-19-2629-01A-01D-1495-08	2216959	93620253	155630368	4	11219											
SSR2	6746	broad.mit.edu	37	chr1	155989853	155989853	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	caaggtcaggtctcgtccctCcacggcgtatctgttcagca	10	14	4	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr1:155989853C>A	uc001fmx.2	-	2	186	c.106G>T	c.(106-108)GAG>TAG	p.E36*	SSR2_uc001fmw.2_RNA|SSR2_uc001fmy.2_RNA|SSR2_uc010pgv.1_Nonsense_Mutation_p.E55*|SSR2_uc010pgw.1_Nonsense_Mutation_p.E55*	NM_003145	NP_003136	P43308	SSRB_HUMAN	signal sequence receptor, beta precursor	36	Lumenal (Potential).				cotranslational protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					TCTCGTCCCTCCACGGCGTAT	0.483													A	155989853	A	A	155989853	4	1	159	1	0	0	0	0	0	1	0	0	15190	864	30	5	465	5	SSR2	1	155989853	Nonsense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	62369600	155989853	93260768	5	11220											
OR6K2	81448	broad.mit.edu	37	chr1	158670186	158670186	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggaaatgctcctctcactaAgcaggctagacagcatcttt	8	11	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr1:158670186A>G	uc001fsu.1	-	1	257	c.257T>C	c.(256-258)CTT>CCT	p.L86P		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					CCTCTCACTAAGCAGGCTAGA	0.458													G	158670186	G	G	158670186	3	3	159	1	0	0	0	0	1	0	0	0	11202	72	3	4	721	4	OR6K2	1	158670186	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	2680333	158670186	90580435	6	11221											
NDUFS2	4720	broad.mit.edu	37	chr1	161182256	161182256	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaagtgtctccacctaagCgagcagagatgaaggttggc	12	10	1	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr1:161182256C>T	uc001fyv.2	+	11	1550	c.1102C>T	c.(1102-1104)CGA>TGA	p.R368*	NDUFS2_uc001fyw.2_Nonsense_Mutation_p.R368*|NDUFS2_uc010pkj.1_Nonsense_Mutation_p.R317*|NDUFS2_uc001fyx.2_Nonsense_Mutation_p.R342*|FCER1G_uc001fyz.1_5'Flank|FCER1G_uc001fza.1_5'Flank	NM_004550	NP_004541	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2	368					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			skin(1)	1	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	TCCACCTAAGCGAGCAGAGAT	0.527													T	161182256	T	T	161182256	4	4	159	1	0	0	0	0	0	1	0	0	10292	760	27	1	1140	1	NDUFS2	1	161182256	Nonsense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	2512070	161182256	88068365	7	11222											
NOS1AP	9722	broad.mit.edu	37	chr1	162257211	162257213	+	In_Frame_Del	DEL	GAA	-	-													gatggagtgaaagtgattctGaagaagaagaaaaaggtaag							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr1:162257211_162257213delGAA	uc001gbv.2	+	3	642_644	c.255_257delGAA	c.(253-258)CTGAAG>CTG	p.K90del	NOS1AP_uc010pkr.1_In_Frame_Del_p.K92del|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_In_Frame_Del_p.K92del	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	90	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			AAGTGATTCTGAAGAAGAAGAAA	0.433													-	162257213	-	-	162257211	7	5	159	1	0	1	0	1	0	0	0	0	10542	1277	45	0	265	0	NOS1AP	1	162257211	In_Frame_Del	DEL	GAA	TCGA-19-2629-01A-01D-1495-08	1074955	162257211	86993410	8	11223											
TNNT2	7139	broad.mit.edu	37	chr1	201331099	201331101	+	In_Frame_Del	DEL	TCT	-	-													cttcctcctctcagccagaaTcttcttcttcttttcccgct					rs45578238		TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr1:201331099_201331101delTCT	uc001gwf.2	-	13	719_721	c.650_652delAGA	c.(649-654)AAGATT>ATT	p.K217del	TNNT2_uc009wzn.2_5'Flank|TNNT2_uc009wzo.2_5'Flank|TNNT2_uc009wzp.2_RNA|TNNT2_uc001gwg.2_In_Frame_Del_p.K207del|TNNT2_uc001gwh.2_In_Frame_Del_p.K204del|TNNT2_uc001gwi.2_In_Frame_Del_p.K177del|TNNT2_uc009wzr.2_In_Frame_Del_p.K148del	NM_000364	NP_000355	P45379	TNNT2_HUMAN	troponin T type 2, cardiac isoform 1	220			Missing (in CMD1D).		ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding				0						TCAGCCAGAATCTTCTTCTTCTT	0.576											OREG0014076	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	201331101	-	-	201331099	7	5	159	1	0	1	0	1	0	0	0	0	16328	1435	50	0	251	0	TNNT2	1	201331099	In_Frame_Del	DEL	TCT	TCGA-19-2629-01A-01D-1495-08	39073888	201331099	47919522	9	11224											
KIDINS220	57498	broad.mit.edu	37	chr2	8872006	8872006	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctgagcaatgtattctctaTaggcatctctatactcggcc	7	11	3	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr2:8872006T>C	uc002qzc.2	-	30	4342	c.4160A>G	c.(4159-4161)TAT>TGT	p.Y1387C	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Missense_Mutation_p.Y1288C|KIDINS220_uc002qzb.2_Missense_Mutation_p.Y241C	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1387	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTATTCTCTATAGGCATCTCT	0.463													C	8872006	C	C	8872006	3	2	159	1	0	0	0	0	1	0	0	0	8271	1406	49	4	1159	4	KIDINS220	2	8872006	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08		8872006	234327367	10	11225											
DPYSL5	56896	broad.mit.edu	37	chr2	27165614	27165616	+	In_Frame_Del	DEL	AGA	-	-													caagaagctggtccagagagAgaaggtgaggtgggaggagg							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr2:27165614_27165616delAGA	uc002rhu.3	+	11	1594_1596	c.1436_1438delAGA	c.(1435-1440)GAGAAG>GAG	p.K480del	DPYSL5_uc002rhv.3_In_Frame_Del_p.K480del	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	480					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCCAGAGAGAGAAGGTGAGGTG	0.557											OREG0014510	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	27165616	-	-	27165614	7	5	159	1	0	1	0	1	0	0	0	0	4750	304	11	0	1474	0	DPYSL5	2	27165614	In_Frame_Del	DEL	AGA	TCGA-19-2629-01A-01D-1495-08	18293608	27165614	216033759	11	11226											
TMEM214	54867	broad.mit.edu	37	chr2	27258019	27258019	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcagctggatgtggcagaccTgcagaaggaactggacaaga	15	8	0	3			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr2:27258019T>A	uc002ria.3	+	3	478	c.368T>A	c.(367-369)CTG>CAG	p.L123Q	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.L123Q	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	123						integral to membrane	protein binding				0						GTGGCAGACCTGCAGAAGGAA	0.537													A	27258019	A	A	27258019	3	1	159	1	0	0	0	0	1	0	0	0	16134	1580	55	5	378	5	TMEM214	2	27258019	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	92405	27258019	215941354	12	11227											
FAM176A	84141	broad.mit.edu	37	chr2	75745200	75745200	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acctgagacaaaggaataggCcgctaggatgttgctgagca	13	8	0	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr2:75745200C>A	uc002sni.2	-	3	545	c.67G>T	c.(67-69)GCC>TCC	p.A23S	FAM176A_uc002snj.1_Missense_Mutation_p.A10S|FAM176A_uc002snk.1_Missense_Mutation_p.A23S	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	23	Necessary for the localization and biological activity.				apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						AAGGAATAGGCCGCTAGGATG	0.612													A	75745200	A	A	75745200	3	1	159	1	0	0	0	0	1	0	0	0	5499	739	26	5	399	5	FAM176A	2	75745200	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	48487181	75745200	167454173	13	11228											
SEPT10	151011	broad.mit.edu	37	chr2	110350668	110350668	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cttgtgaagacatacaagttGttttcgttgccatgtgagac	10	7	0	3			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr2:110350668G>C	uc002tew.2	-	2	438	c.59C>G	c.(58-60)ACA>AGA	p.T20R	SEPT10_uc010ywu.1_Missense_Mutation_p.T20R|SEPT10_uc002tex.2_Intron|SEPT10_uc002tey.2_Missense_Mutation_p.T20R|SEPT10_uc010ywv.1_5'UTR	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1	20					cell cycle|cell division	septin complex	GTP binding				0						CATACAAGTTGTTTTCGTTGC	0.323													C	110350668	C	C	110350668	3	2	159	1	0	0	0	0	1	0	0	0	14060	1377	48	5	1345	5	SEPT10	2	110350668	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	34605468	110350668	132848705	14	11229											
NEB	4703	broad.mit.edu	37	chr2	152518698	152518698	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaaccatgttcatcgagTccatgagtgtggaatacttc	8	10	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr2:152518698T>C	uc010fnx.2	-	46	6112	c.5921A>G	c.(5920-5922)GAC>GGC	p.D1974G		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1974	Nebulin 52.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTTCATCGAGTCCATGAGTGT	0.413													C	152518698	C	C	152518698	3	2	159	1	0	0	0	0	1	0	0	0	10302	1667	58	4	20313	4	NEB	2	152518698	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	42168030	152518698	90680675	15	11230											
LASS6	253782	broad.mit.edu	37	chr2	169404150	169404150	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agccctcaacattcaggccaAtggaccacaaattgctccgc	7	15	2	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr2:169404150A>G	uc002ueb.1	+	2	339	c.215A>G	c.(214-216)AAT>AGT	p.N72S	LASS6_uc002uec.1_Missense_Mutation_p.N72S	NM_203463	NP_982288	Q6ZMG9	CERS6_HUMAN	longevity assurance homolog 6	72	Cytoplasmic (Potential).|Homeobox.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			skin(1)	1						ATTCAGGCCAATGGACCACAA	0.413													G	169404150	G	G	169404150	3	3	159	1	0	0	0	0	1	0	0	0	8643	101	4	4	221	4	LASS6	2	169404150	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	16885452	169404150	73795223	16	11231											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	159	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	39708962	209113112	34086261	17	11232											
ZNF142	7701	broad.mit.edu	37	chr2	219521105	219521105	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcagggcacagtccatccatCtccccggtgctactggctgg	11	15	2	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr2:219521105C>T	uc002vin.2	-	4	484	c.48G>A	c.(46-48)GAG>GAA	p.E16E	ZNF142_uc002vil.2_5'UTR|ZNF142_uc010fvt.2_5'UTR|ZNF142_uc002vim.2_5'UTR|BCS1L_uc002vio.2_5'Flank	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GTCCATCCATCTCCCCGGTGC	0.582													T	219521105	T	T	219521105	2	4	159	1	0	0	0	0	0	0	0	1	17728	912	32	3		3	ZNF142	2	219521105	Silent	SNP	C	TCGA-19-2629-01A-01D-1495-08	10407993	219521105	23678268	18	11233											
NUP210	23225	broad.mit.edu	37	chr3	13432743	13432743	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggagtctgagaacctgtcCgcctcggagtccttcacaat	11	12	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr3:13432743C>T	uc003bxv.1	-	4	584	c.501G>A	c.(499-501)GCG>GCA	p.A167A		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	167	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					AGAACCTGTCCGCCTCGGAGT	0.582													T	13432743	T	T	13432743	2	4	159	1	0	0	0	0	0	0	0	1	10760	639	23	2		2	NUP210	3	13432743	Silent	SNP	C	TCGA-19-2629-01A-01D-1495-08		13432743	184589687	19	11234											
MRPS25	64432	broad.mit.edu	37	chr3	15094113	15094115	+	In_Frame_Del	DEL	CTC	-	-													gggtgagaaagctgctttttCtcctcctcctcttccctgag							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr3:15094113_15094115delCTC	uc003bzl.2	-	4	470_472	c.355_357delGAG	c.(355-357)GAGdel	p.E119del	MRPS25_uc011avl.1_In_Frame_Del_p.89_90RR>R|MRPS25_uc011avm.1_Intron	NM_022497	NP_071942	P82663	RT25_HUMAN	mitochondrial ribosomal protein S25	119					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						GCTGCTTTTTCTCCTCCTCCTCT	0.586													-	15094115	-	-	15094113	7	5	159	1	0	1	0	1	0	0	0	0	9836	912	32	0	168	0	MRPS25	3	15094113	In_Frame_Del	DEL	CTC	TCGA-19-2629-01A-01D-1495-08	1661370	15094113	182928317	20	11235											
NICN1	84276	broad.mit.edu	37	chr3	49463788	49463788	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcacccacttggcaggtgtgTgtgctgaggtgtactgacgg	15	9	1	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr3:49463788T>G	uc003cwz.1	-	2	291	c.206A>C	c.(205-207)CAC>CCC	p.H69P	NICN1_uc003cxa.2_RNA|NICN1_uc011bcr.1_Missense_Mutation_p.H69P	NM_032316	NP_115692	Q9BSH3	NICN1_HUMAN	nicolin 1	69						microtubule|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;4.52e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGCAGGTGTGTGTGCTGAGGT	0.498													G	49463788	G	G	49463788	3	3	159	1	0	0	0	0	1	0	0	0	10413	1696	59	5	455	5	NICN1	3	49463788	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	34369675	49463788	148558642	21	11236											
TMEM115	11070	broad.mit.edu	37	chr3	50396188	50396190	+	In_Frame_Del	DEL	AGA	-	-													tacagacacattcaccactgAgaagaagatgagcagctcca							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr3:50396188_50396190delAGA	uc003dan.1	-	1	750_752	c.305_307delTCT	c.(304-309)TTCTCA>TCA	p.F102del		NM_007024	NP_008955	Q12893	TM115_HUMAN	PL6 protein	102	Helical; (Potential).				negative regulation of cell proliferation	Golgi apparatus|integral to membrane|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TTCACCACTGAGAAGAAGATGAG	0.601													-	50396190	-	-	50396188	7	5	159	1	0	1	0	1	0	0	0	0	16026	304	11	0	756	0	TMEM115	3	50396188	In_Frame_Del	DEL	AGA	TCGA-19-2629-01A-01D-1495-08	932400	50396188	147626242	22	11237											
C3orf17	25871	broad.mit.edu	37	chr3	112724550	112724550	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttagtttgtatgacaggcaTtgaaactccactattcaaga	7	8	1	3			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr3:112724550T>C	uc003dzr.2	-	9	1598	c.1537A>G	c.(1537-1539)ATG>GTG	p.M513V	GTPBP8_uc011bhy.1_Intron|C3orf17_uc003dzq.2_Missense_Mutation_p.M138V|C3orf17_uc011bhz.1_Missense_Mutation_p.M138V|C3orf17_uc010hqh.2_Missense_Mutation_p.M138V|C3orf17_uc003dzt.2_Missense_Mutation_p.M416V|C3orf17_uc003dzs.2_Missense_Mutation_p.M377V|C3orf17_uc010hqg.2_Missense_Mutation_p.M338V|C3orf17_uc011bia.1_Missense_Mutation_p.M310V|C3orf17_uc003dzu.2_Missense_Mutation_p.M442V|C3orf17_uc011bib.1_Missense_Mutation_p.M402V|C3orf17_uc011bic.1_Missense_Mutation_p.M346V|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	513						integral to membrane					0						ATGACAGGCATTGAAACTCCA	0.388													C	112724550	C	C	112724550	3	2	159	1	0	0	0	0	1	0	0	0	2210	1493	52	4	170	4	C3orf17	3	112724550	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	62328362	112724550	85297880	23	11238											
CCDC37	348807	broad.mit.edu	37	chr3	126138549	126138549	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatttcctatacaagctgtcGcccaaggagtggcttgaaga	11	9	0	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr3:126138549G>A	uc003eiu.1	+	9	900	c.801G>A	c.(799-801)TCG>TCA	p.S267S	CCDC37_uc010hsg.1_Silent_p.S268S	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	267										ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		ACAAGCTGTCGCCCAAGGAGT	0.488													A	126138549	A	A	126138549	2	1	159	1	0	0	0	0	0	0	0	1	2809	1074	38	1		1	CCDC37	3	126138549	Silent	SNP	G	TCGA-19-2629-01A-01D-1495-08	13413999	126138549	71883881	24	11239											
CP	1356	broad.mit.edu	37	chr3	148903188	148903188	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtatatttttgcttcatgCcgcctgtgtaatgatcagtt	8	8	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr3:148903188C>T	uc003ewy.3	-	12	2376	c.2123G>A	c.(2122-2124)GGC>GAC	p.G708D	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Missense_Mutation_p.G489D|CP_uc003ewz.2_Missense_Mutation_p.G708D	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	708	Plastocyanin-like 4.|F5/8 type A 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TTGCTTCATGCCGCCTGTGTA	0.368													T	148903188	T	T	148903188	3	4	159	1	0	0	0	0	1	0	0	0	3787	739	26	3	1106	3	CP	3	148903188	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	22764639	148903188	49119242	25	11240											
VEPH1	79674	broad.mit.edu	37	chr3	157213090	157213090	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taaggagaagaggtccccagCtcgtgaaagatctttttgtc	11	8	1	4			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr3:157213090C>A	uc003fbj.1	-	2	366	c.49G>T	c.(49-51)GCT>TCT	p.A17S	VEPH1_uc003fbk.1_Missense_Mutation_p.A17S|VEPH1_uc010hvu.1_Missense_Mutation_p.A17S|VEPH1_uc003fbm.2_Missense_Mutation_p.A17S|VEPH1_uc003fbn.2_Missense_Mutation_p.A17S	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	17						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			AGGTCCCCAGCTCGTGAAAGA	0.413													A	157213090	A	A	157213090	3	1	159	1	0	0	0	0	1	0	0	0	17151	797	28	5	2626	5	VEPH1	3	157213090	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	8309902	157213090	40809340	26	11241											
TP63	8626	broad.mit.edu	37	chr3	189607256	189607256	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cccccacctccgtatcccacAgattgcagcattgtcaggtg	8	16	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr3:189607256A>G	uc003fry.2	+	12	1724	c.1635A>G	c.(1633-1635)ACA>ACG	p.T545T	TP63_uc003frz.2_Silent_p.T545T|TP63_uc010hzc.1_Intron|TP63_uc003fsc.2_Silent_p.T451T|TP63_uc003fsd.2_Silent_p.T451T|TP63_uc010hzd.1_Silent_p.T366T	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	545	SAM.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CGTATCCCACAGATTGCAGCA	0.597									Hay-Wells_syndrome	HNSCC(45;0.13)			G	189607256	G	G	189607256	2	3	159	1	0	0	0	0	0	0	0	1	16389	175	7	4		4	TP63	3	189607256	Silent	SNP	A	TCGA-19-2629-01A-01D-1495-08	32394166	189607256	8415174	27	11242											
LGI2	55203	broad.mit.edu	37	chr4	25019723	25019723	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtggaatttgtcatcttcaaCcacaggtatagccacttggc	9	10	3	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr4:25019723C>A	uc003grf.2	-	6	642	c.543G>T	c.(541-543)TGG>TGT	p.W181C		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	181	LRRCT.					extracellular region					0		Breast(46;0.173)				TCATCTTCAACCACAGGTATA	0.373													A	25019723	A	A	25019723	3	1	159	1	0	0	0	0	1	0	0	0	8752	508	18	5	1106	5	LGI2	4	25019723	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08		25019723	166134553	28	11243											
UGT2A3	79799	broad.mit.edu	37	chr4	69798344	69798344	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caggattggaggttttactgAccttctgtgggatctgggca	14	7	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr4:69798344A>G	uc003hef.2	-	3	1027	c.996_splice	c.e3+1	p.K332_splice	UGT2A3_uc010ihp.1_Splice_Site	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,							integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GGTTTTACTGACCTTCTGTGG	0.398													G	69798344	G	G	69798344	5	3	159	1	0	0	0	0	0	0	1	0	16952	289	10	4	601	4	UGT2A3	4	69798344	Splice_Site	SNP	A	TCGA-19-2629-01A-01D-1495-08	44778621	69798344	121355932	29	11244											
USP53	54532	broad.mit.edu	37	chr4	120213685	120213686	+	Frame_Shift_Del	DEL	CT	-	-													ttgccttttcacgttgataaCtctgcttctgggaagagagt							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr4:120213685_120213686delCT	uc003ics.3	+	18	3607_3608	c.2541_2542delCT	c.(2539-2544)AACTCTfs	p.N847fs	USP53_uc003icr.3_Frame_Shift_Del_p.N847fs|USP53_uc003icu.3_Frame_Shift_Del_p.N470fs	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	847_848					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						ACGTTGATAACTCTGCTTCTGG	0.391													-	120213686	-	-	120213685	7	5	159	1	0	1	0	1	0	0	0	0	17081	564	20	0	2599	0	USP53	4	120213685	Frame_Shift_Del	DEL	CT	TCGA-19-2629-01A-01D-1495-08	50415341	120213685	70940591	30	11245											
PCDH18	54510	broad.mit.edu	37	chr4	138442804	138442804	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agtggtggcatccagcactgGtcagagtgtcccaggaccct	13	12	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr4:138442804G>T	uc003ihe.3	-	4	3174	c.2787C>A	c.(2785-2787)GAC>GAA	p.D929E	PCDH18_uc003ihf.3_Missense_Mutation_p.D921E|PCDH18_uc011cgz.1_Missense_Mutation_p.D140E|PCDH18_uc003ihg.3_Missense_Mutation_p.D708E|PCDH18_uc011cha.1_Missense_Mutation_p.D109E	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	929	Interaction with DAB1 (By similarity).|Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TCCAGCACTGGTCAGAGTGTC	0.498													T	138442804	T	T	138442804	3	4	159	1	0	0	0	0	1	0	0	0	11513	1252	44	5	624	5	PCDH18	4	138442804	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	18229119	138442804	52711472	31	11246											
SPOCK3	50859	broad.mit.edu	37	chr4	167921580	167921580	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	actttatggcgactacatttCatctttaagcatggatcctt	6	9	2	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr4:167921580C>T	uc003iri.1	-	5	420	c.279G>A	c.(277-279)ATG>ATA	p.M93I	SPOCK3_uc011cjp.1_Missense_Mutation_p.M90I|SPOCK3_uc011cjq.1_Missense_Mutation_p.M102I|SPOCK3_uc011cjr.1_Intron|SPOCK3_uc003irj.1_Missense_Mutation_p.M90I|SPOCK3_uc011cjs.1_Missense_Mutation_p.M42I|SPOCK3_uc011cjt.1_Missense_Mutation_p.M1I|SPOCK3_uc011cju.1_Intron|SPOCK3_uc011cjv.1_Intron|SPOCK3_uc003irk.3_Missense_Mutation_p.M90I|SPOCK3_uc011cjw.1_RNA	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	93					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		GACTACATTTCATCTTTAAGC	0.348													T	167921580	T	T	167921580	3	4	159	1	0	0	0	0	1	0	0	0	15080	826	29	3	1063	3	SPOCK3	4	167921580	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	29478776	167921580	23232696	32	11247											
MFAP3L	9848	broad.mit.edu	37	chr4	170926952	170926952	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtcacactcttagcggtgGctagagtggatactaggatt	12	7	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr4:170926952G>A	uc003isp.3	-	2	255	c.77C>T	c.(76-78)GCC>GTC	p.A26V	MFAP3L_uc003isn.3_5'Flank	NM_021647	NP_067679	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like isoform	26						integral to membrane|plasma membrane				ovary(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		CTTAGCGGTGGCTAGAGTGGA	0.458													A	170926952	A	A	170926952	3	1	159	1	0	0	0	0	1	0	0	0	9516	1203	42	3	1160	3	MFAP3L	4	170926952	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	3005372	170926952	20227324	33	11248											
TLR3	7098	broad.mit.edu	37	chr4	187003773	187003773	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctagagtataataatatacaGcatttgttttctcactcttt	4	7	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr4:187003773G>A	uc003iyq.2	+	4	1034	c.933G>A	c.(931-933)CAG>CAA	p.Q311Q	TLR3_uc011ckz.1_Silent_p.Q34Q|TLR3_uc003iyr.2_Silent_p.Q34Q	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	311	Lumenal (Potential).|LRR 11.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		ATAATATACAGCATTTGTTTT	0.383													A	187003773	A	A	187003773	2	1	159	1	0	0	0	0	0	0	0	1	15949	962	34	3		3	TLR3	4	187003773	Silent	SNP	G	TCGA-19-2629-01A-01D-1495-08	16076821	187003773	4150503	34	11249											
SPEF2	79925	broad.mit.edu	37	chr5	35771803	35771804	+	Frame_Shift_Ins	INS	-	A	A													ctcctcagatgggtgcaaatINSaaaaaagtcaaaaaggagcc							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr5:35771803_35771804insA	uc003jjo.2	+	27	4005_4006	c.3894_3895insA	c.(3892-3897)AATAAAfs	p.N1298fs	SPEF2_uc003jjp.1_Frame_Shift_Ins_p.N784fs|SPEF2_uc003jjr.2_5'Flank	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1298_1299					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGGGTGCAAATAAAAAAGTCAA	0.426													A	35771804	A	A	35771803	7	5	159	1	0	1	1	0	0	0	0	0	15034	1403	49	0	4021	0	SPEF2	5	35771803	Frame_Shift_Ins	INS	-	TCGA-19-2629-01A-01D-1495-08		35771803	145143457	35	11250											
PIK3R1	5295	broad.mit.edu	37	chr5	67589619	67589621	+	In_Frame_Del	DEL	GAG	-	-													tcagtttcaagaaaaaagtcGagaatatgatagattatatg							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr5:67589619_67589621delGAG	uc003jva.2	+	11	1942_1944	c.1382_1384delGAG	c.(1381-1386)CGAGAA>CAA	p.461_462RE>Q	PIK3R1_uc003jvb.2_In_Frame_Del_p.461_462RE>Q|PIK3R1_uc003jvc.2_In_Frame_Del_p.161_162RE>Q|PIK3R1_uc003jvd.2_In_Frame_Del_p.191_192RE>Q|PIK3R1_uc003jve.2_In_Frame_Del_p.140_141RE>Q|PIK3R1_uc011crb.1_In_Frame_Del_p.131_132RE>Q	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	461_462					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.?(1)|p.F456_R461>S(1)|p.Q457_R461del(1)|p.F456_R461del(1)|p.R461*(1)|p.T454_D464del(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GAAAAAAGTCGAGAATATGATAG	0.281			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67589621	-	-	67589619	7	5	159	1	0	1	0	1	0	0	0	0	11918	1058	37	0	1550	0	PIK3R1	5	67589619	In_Frame_Del	DEL	GAG	TCGA-19-2629-01A-01D-1495-08	31817816	67589619	113325641	36	11251											
HOMER1	9456	broad.mit.edu	37	chr5	78752779	78752781	+	In_Frame_Del	DEL	TTC	-	-													gcttgctggtgggtacccagTtcttctttgtgtttgggtca							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr5:78752779_78752781delTTC	uc003kfy.2	-	2	1169_1171	c.66_68delGAA	c.(64-69)AAGAAC>AAC	p.K22del	HOMER1_uc010jab.2_In_Frame_Del_p.K22del|HOMER1_uc010jac.2_In_Frame_Del_p.K22del|HOMER1_uc010jad.2_Intron	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	22	WH1.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		GGGTACCCAGTTCTTCTTTGTGT	0.433													-	78752781	-	-	78752779	7	5	159	1	0	1	0	1	0	0	0	0	7278	1725	60	0	1028	0	HOMER1	5	78752779	In_Frame_Del	DEL	TTC	TCGA-19-2629-01A-01D-1495-08	11163160	78752779	102162481	37	11252											
FAT2	2196	broad.mit.edu	37	chr5	150934173	150934173	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gattgtcattgacgtccaagAtgcctaccaccaccctggag	9	13	1	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr5:150934173A>G	uc003lue.3	-	4	3708	c.3695T>C	c.(3694-3696)ATC>ACC	p.I1232T	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1232	Extracellular (Potential).|Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GACGTCCAAGATGCCTACCAC	0.552													G	150934173	G	G	150934173	3	3	159	1	0	0	0	0	1	0	0	0	5690	333	12	4	9434	4	FAT2	5	150934173	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	72181394	150934173	29981087	38	11253											
TIMD4	91937	broad.mit.edu	37	chr5	156381617	156381617	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaccctcattccatcagtgCggatgagcgcctccttgcaa	8	15	3	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr5:156381617C>T	uc003lwh.2	-	2	266	c.209G>A	c.(208-210)CGC>CAC	p.R70H	TIMD4_uc010jii.2_Missense_Mutation_p.R70H	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	70	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCCATCAGTGCGGATGAGCGC	0.522													T	156381617	T	T	156381617	3	4	159	1	0	0	0	0	1	0	0	0	15900	768	27	1	959	1	TIMD4	5	156381617	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	5447444	156381617	24533643	39	11254											
FGFR4	2264	broad.mit.edu	37	chr5	176520301	176520301	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccgcccgcccgccactgtgcAgaagctctcccgcttccctc	8	22	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr5:176520301A>C	uc003mfl.2	+	9	1387	c.1220A>C	c.(1219-1221)CAG>CCG	p.Q407P	FGFR4_uc003mfm.2_Missense_Mutation_p.Q407P|FGFR4_uc011dfu.1_Intron|FGFR4_uc011dfw.1_3'UTR|FGFR4_uc003mfo.2_Intron	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	407	Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GCCACTGTGCAGAAGCTCTCC	0.692										TSP Lung(9;0.080)			C	176520301	C	C	176520301	3	2	159	1	0	0	0	0	1	0	0	0	5868	188	7	5	1250	5	FGFR4	5	176520301	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	20138684	176520301	4394959	40	11255											
KIAA0319	9856	broad.mit.edu	37	chr6	24563608	24563608	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgagatccgagtgggcccgaAtcttctggaccttaatgtcc	11	11	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr6:24563608A>G	uc011djo.1	-	16	2807	c.2570T>C	c.(2569-2571)ATT>ACT	p.I857T	KIAA0319_uc011djp.1_Missense_Mutation_p.I812T|KIAA0319_uc003neh.1_Missense_Mutation_p.I857T|KIAA0319_uc011djq.1_Missense_Mutation_p.I848T|KIAA0319_uc011djr.1_Missense_Mutation_p.I857T|KIAA0319_uc010jpt.1_Missense_Mutation_p.I268T	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	857	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						GTGGGCCCGAATCTTCTGGAC	0.567													G	24563608	G	G	24563608	3	3	159	1	0	0	0	0	1	0	0	0	8168	101	4	4	672	4	KIAA0319	6	24563608	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08		24563608	146551459	41	11256											
HIST1H3F	8968	broad.mit.edu	37	chr6	26250643	26250643	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgctggaatggtagcttgCgaatcagtagctcagtcgat	13	8	2	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr6:26250643C>T	uc003nhg.1	-	1	193	c.191G>A	c.(190-192)CGC>CAC	p.R64H	HIST1H2BH_uc003nhh.2_5'Flank	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	64					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						TGGTAGCTTGCGAATCAGTAG	0.612											OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	26250643	T	T	26250643	3	4	159	1	0	0	0	0	1	0	0	0	7160	768	27	1	223	1	HIST1H3F	6	26250643	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	1687035	26250643	144864424	42	11257											
TULP1	7287	broad.mit.edu	37	chr6	35477607	35477607	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccctaggctgggctcaccttTcttcttggtctttctcatct	7	14	6	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr6:35477607T>C	uc003okv.3	-	6	610	c.598A>G	c.(598-600)AAA>GAA	p.K200E	TULP1_uc003okw.3_Missense_Mutation_p.K147E	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	200					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						GGCTCACCTTTCTTCTTGGTC	0.592													C	35477607	C	C	35477607	3	2	159	1	0	0	0	0	1	0	0	0	16770	1792	62	4	1070	4	TULP1	6	35477607	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	9226964	35477607	135637460	43	11258											
CAPN11	11131	broad.mit.edu	37	chr6	44140965	44140965	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtgcccacaggctgagtgggTcctatgaagcattgtcaggg	15	9	1	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr6:44140965T>A	uc003owt.1	+	7	711	c.673T>A	c.(673-675)TCC>ACC	p.S225T		NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	225	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GCTGAGTGGGTCCTATGAAGC	0.617											OREG0017466	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	44140965	A	A	44140965	3	1	159	1	0	0	0	0	1	0	0	0	2624	1667	58	5	699	5	CAPN11	6	44140965	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	8663358	44140965	126974102	44	11259											
RAB23	51715	broad.mit.edu	37	chr6	57055306	57055309	+	Frame_Shift_Del	DEL	TTTG	-	-													atttctgtttttcttggtccTttgtttgttgggtctaagat							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr6:57055306_57055309delTTTG	uc003pds.2	-	7	870_873	c.664_667delCAAA	c.(664-669)CAAAGGfs	p.Q222fs	RAB23_uc003pdt.2_Frame_Shift_Del_p.Q222fs|RAB23_uc010kac.2_Frame_Shift_Del_p.Q222fs|RAB23_uc010kad.2_RNA	NM_183227	NP_899050	Q9ULC3	RAB23_HUMAN	Ras-related protein Rab-23	222_223					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			skin(1)	1	Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTCTTGGTCCTTTGTTTGTTGGGT	0.387													-	57055309	-	-	57055306	7	5	159	1	0	1	0	1	0	0	0	0	12910	1608	56	0	50	0	RAB23	6	57055306	Frame_Shift_Del	DEL	TTTG	TCGA-19-2629-01A-01D-1495-08	12914341	57055306	114059761	45	11260											
SPACA1	81833	broad.mit.edu	37	chr6	88769216	88769216	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagcaatcctagaagtacgcAaggaaagtcaccccttggct	9	12	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr6:88769216A>C	uc003pmn.2	+	5	637	c.520A>C	c.(520-522)AAG>CAG	p.K174Q		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor	174	Extracellular (Potential).					integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		AGAAGTACGCAAGGAAAGTCA	0.343													C	88769216	C	C	88769216	3	2	159	1	0	0	0	0	1	0	0	0	14972	131	5	5	538	5	SPACA1	6	88769216	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	31713910	88769216	82345851	46	11261											
ASCC3	10973	broad.mit.edu	37	chr6	101110219	101110219	+	Splice_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atcaaggaaggtaagctcttAccttaataataacagcatgg	8	7	2	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr6:101110219A>T	uc003pqk.2	-	15	2807	c.2478_splice	c.e15+1	p.K826_splice	ASCC3_uc011eai.1_Splice_Site_p.K728_splice	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		GTAAGCTCTTACCTTAATAAT	0.398													T	101110219	T	T	101110219	5	4	159	1	0	0	0	0	0	0	1	0	1033	405	14	5	4240	5	ASCC3	6	101110219	Splice_Site	SNP	A	TCGA-19-2629-01A-01D-1495-08	12341003	101110219	70004848	47	11262											
CCDC129	223075	broad.mit.edu	37	chr7	31617703	31617703	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtaacccagaggtatcagaGtccttcaaggtgaaggatga	12	7	2	4			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr7:31617703G>A	uc003tcj.1	+	8	1818	c.825G>A	c.(823-825)GAG>GAA	p.E275E	CCDC129_uc011kad.1_Silent_p.E285E|CCDC129_uc003tci.1_Intron|CCDC129_uc011kae.1_Silent_p.E301E|CCDC129_uc003tck.1_Silent_p.E183E	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	275											0						AGGTATCAGAGTCCTTCAAGG	0.453													A	31617703	A	A	31617703	2	1	159	1	0	0	0	0	0	0	0	1	2764	1020	36	3		3	CCDC129	7	31617703	Silent	SNP	G	TCGA-19-2629-01A-01D-1495-08		31617703	127520960	48	11263											
TRIM74	378108	broad.mit.edu	37	chr7	75028495	75028495	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaggtctgcgtgcaccaccGgaacccgctcagccttttct	9	16	3	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr7:75028495G>A	uc003udc.1	+	2	478	c.278G>A	c.(277-279)CGG>CAG	p.R93Q	TRIM74_uc010ldc.2_Missense_Mutation_p.R93Q|TRIM74_uc010ldd.2_Missense_Mutation_p.R93Q	NM_198924	NP_944606	Q86UV6	TRI74_HUMAN	tripartite motif-containing 73	93	B box-type.					intracellular	zinc ion binding				0						GTGCACCACCGGAACCCGCTC	0.667													A	75028495	A	A	75028495	3	1	159	1	0	0	0	0	1	0	0	0	16544	1116	39	2	280	2	TRIM74	7	75028495	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	43410792	75028495	84110168	49	11264											
SMURF1	57154	broad.mit.edu	37	chr7	98636097	98636099	+	In_Frame_Del	DEL	GTT	-	-													tgcaggatccgcccgaaggcGttgtgttccacgcagaaggt							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr7:98636097_98636099delGTT	uc003upu.1	-	15	1998_2000	c.1678_1680delAAC	c.(1678-1680)AACdel	p.N560del	SMURF1_uc003upv.1_In_Frame_Del_p.N534del|SMURF1_uc003upt.2_In_Frame_Del_p.N534del	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	560	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GCCCGAAGGCGTTGTGTTCCACG	0.512													-	98636099	-	-	98636097	7	5	159	1	0	1	0	1	0	0	0	0	14819	1136	40	0	613	0	SMURF1	7	98636097	In_Frame_Del	DEL	GTT	TCGA-19-2629-01A-01D-1495-08	23607602	98636097	60502566	50	11265											
CFTR	1080	broad.mit.edu	37	chr7	117180363	117180363	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atttccctgggctgtacaaaCatggtatgactctcttggag	10	9	1	1	rs75053309		TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr7:117180363C>G	uc003vjd.2	+	8	1211	c.1079C>G	c.(1078-1080)ACA>AGA	p.T360R	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	360	Cytoplasmic (Potential).|ABC transmembrane type-1 1.		QT -> KK (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GCTGTACAAACATGGTATGAC	0.388									Cystic_Fibrosis				G	117180363	G	G	117180363	3	3	159	1	0	0	0	0	1	0	0	0	3294	478	17	5	1109	5	CFTR	7	117180363	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	18544266	117180363	41958300	51	11266											
SSPO	23145	broad.mit.edu	37	chr7	149477563	149477563	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgtgcgccagctgtgtaaccCctggtgggtccttgagccat	13	13	0	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr7:149477563C>A	uc010lpk.2	+	12	1634	c.1634C>A	c.(1633-1635)CCC>CAC	p.P545H	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	545					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGTGTAACCCCTGGTGGGTC	0.627													A	149477563	A	A	149477563	3	1	159	1	0	0	0	0	1	0	0	0	15188	623	22	5	1678	5	SSPO	7	149477563	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	32297200	149477563	9661100	52	11267											
POLR3D	661	broad.mit.edu	37	chr8	22106020	22106020	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgaccccggcctgaggaaCgacactcgaaatatgcctgt	11	12	0	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr8:22106020C>T	uc003xbl.2	+	6	596	c.513C>T	c.(511-513)AAC>AAT	p.N171N	POLR3D_uc003xbm.2_Silent_p.N171N|POLR3D_uc011kze.1_RNA	NM_001722	NP_001713	P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	171					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity				0				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		GCCTGAGGAACGACACTCGAA	0.527													T	22106020	T	T	22106020	2	4	159	1	0	0	0	0	0	0	0	1	12231	535	19	1		1	POLR3D	8	22106020	Silent	SNP	C	TCGA-19-2629-01A-01D-1495-08		22106020	124258002	53	11268											
KCTD9	54793	broad.mit.edu	37	chr8	25287394	25287394	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catctgacactttgtgacatGtgtagtggtgtcagcatctc	10	9	3	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr8:25287394G>A	uc003xeo.2	-	12	1307	c.1149C>T	c.(1147-1149)CAC>CAT	p.H383H	PPP2R2A_uc003xek.2_Intron|KCTD9_uc011lad.1_RNA	NM_017634	NP_060104	Q7L273	KCTD9_HUMAN	potassium channel tetramerisation domain	383						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)		TTTGTGACATGTGTAGTGGTG	0.428													A	25287394	A	A	25287394	2	1	159	1	0	0	0	0	0	0	0	1	8116	1368	48	3		3	KCTD9	8	25287394	Silent	SNP	G	TCGA-19-2629-01A-01D-1495-08	3181374	25287394	121076628	54	11269											
FAM110B	90362	broad.mit.edu	37	chr8	59058884	59058884	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcccctgcgcatcctgaacaAggggccagactacttccgca	10	16	0	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr8:59058884A>T	uc003xtj.1	+	5	975	c.95A>T	c.(94-96)AAG>ATG	p.K32M		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	32						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				ATCCTGAACAAGGGGCCAGAC	0.657													T	59058884	T	T	59058884	3	4	159	1	0	0	0	0	1	0	0	0	5397	72	3	5	97	5	FAM110B	8	59058884	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	33771490	59058884	87305138	55	11270											
NCOA2	10499	broad.mit.edu	37	chr8	71069277	71069277	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcattcccccagaaccaccAaacctgcccatgggcatgcc	6	18	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr8:71069277A>G	uc003xyn.1	-	11	1485	c.1323T>C	c.(1321-1323)TTT>TTC	p.F441F		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	441					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			CAGAACCACCAAACCTGCCCA	0.502			T	RUNXBP2	AML								G	71069277	G	G	71069277	2	3	159	1	0	0	0	0	0	0	0	1	10229	127	5	4		4	NCOA2	8	71069277	Silent	SNP	A	TCGA-19-2629-01A-01D-1495-08	12010393	71069277	75294745	56	11271											
SLC7A13	157724	broad.mit.edu	37	chr8	87235301	87235301	+	Frame_Shift_Del	DEL	G	-	-													aacgcagtaaatatgcatttGggaattgttgttctgggctt							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr8:87235301delG	uc003ydq.1	-	2	815	c.717delC	c.(715-717)CCCfs	p.P239fs	SLC7A13_uc003ydr.1_Frame_Shift_Del_p.P230fs	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	239	Cytoplasmic (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						ATATGCATTTGGGAATTGTTG	0.358													-	87235301	-	-	87235301	7	5	159	1	0	1	0	1	0	0	0	0	14695	1335	47	0	707	0	SLC7A13	8	87235301	Frame_Shift_Del	DEL	G	TCGA-19-2629-01A-01D-1495-08	16166024	87235301	59128721	57	11272											
NCALD	83988	broad.mit.edu	37	chr8	102705056	102705056	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atctggcggaagatcttttcTgttcttttctctggggttga	11	7	5	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr8:102705056T>C	uc003yke.2	-	3	816	c.447A>G	c.(445-447)ACA>ACG	p.T149T	NCALD_uc003ykf.2_Silent_p.T149T|NCALD_uc003ykg.2_Silent_p.T149T|NCALD_uc003ykh.2_Silent_p.T149T|NCALD_uc003yki.2_Silent_p.T149T|NCALD_uc003ykj.2_Silent_p.T149T|NCALD_uc003ykk.2_Silent_p.T149T|NCALD_uc003ykl.2_Silent_p.T149T	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	149	EF-hand 4.				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			AGATCTTTTCTGTTCTTTTCT	0.507													C	102705056	C	C	102705056	2	2	159	1	0	0	0	0	0	0	0	1	10201	1567	55	4		4	NCALD	8	102705056	Silent	SNP	T	TCGA-19-2629-01A-01D-1495-08	15469755	102705056	43658966	58	11273											
PKHD1L1	93035	broad.mit.edu	37	chr8	110460477	110460477	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgtaatgtaaccatggccaAtgatagtgtggtgcagtgca	13	6	0	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr8:110460477A>G	uc003yne.2	+	39	5986	c.5882A>G	c.(5881-5883)AAT>AGT	p.N1961S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1961	Extracellular (Potential).|IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACCATGGCCAATGATAGTGTG	0.438										HNSCC(38;0.096)			G	110460477	G	G	110460477	3	3	159	1	0	0	0	0	1	0	0	0	11972	101	4	4	6036	4	PKHD1L1	8	110460477	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	7755421	110460477	35903545	59	11274											
FER1L6	654463	broad.mit.edu	37	chr8	125047566	125047566	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgcaagcaaaagtcgacGtgtacctgtggctgggctcc	13	11	0	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr8:125047566G>A	uc003yqw.2	+	19	2541	c.2335G>A	c.(2335-2337)GTG>ATG	p.V779M	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	779	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAAAGTCGACGTGTACCTGTG	0.493													A	125047566	A	A	125047566	3	1	159	1	0	0	0	0	1	0	0	0	5815	1145	40	1	2405	1	FER1L6	8	125047566	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	14587089	125047566	21316456	60	11275											
DGAT1	8694	broad.mit.edu	37	chr8	145540703	145540703	+	Frame_Shift_Del	DEL	G	-	-													acctcgtggaagaaggccgaGgccaggaacacccctgtcct							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr8:145540703delG	uc003zbv.3	-	15	1498	c.1230delC	c.(1228-1230)GCCfs	p.A410fs	DGAT1_uc010mfv.2_Frame_Shift_Del_p.L245fs	NM_012079	NP_036211	O75907	DGAT1_HUMAN	diacylglycerol O-acyltransferase 1	410	Lumenal (Potential).				triglyceride biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;7.67e-40)|all cancers(56;7.88e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			AGAAGGCCGAGGCCAGGAACA	0.637													-	145540703	-	-	145540703	7	5	159	1	0	1	0	1	0	0	0	0	4457	987	35	0	248	0	DGAT1	8	145540703	Frame_Shift_Del	DEL	G	TCGA-19-2629-01A-01D-1495-08	20493137	145540703	823319	61	11276											
FXN	2395	broad.mit.edu	37	chr9	71687595	71687595	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	acgacggcgtgtccctccatGagctgctggccgcagagctc	13	15	0	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr9:71687595G>T	uc004aha.2	+	5	770	c.550G>T	c.(550-552)GAG>TAG	p.E184*	FXN_uc011lrr.1_Intron|FXN_uc004agz.2_Missense_Mutation_p.M186I	NM_000144	NP_000135	Q16595	FRDA_HUMAN	frataxin isoform 1 preproprotein	184					cellular iron ion homeostasis|cellular response to hydrogen peroxide|heme biosynthetic process|ion transport|iron incorporation into metallo-sulfur cluster|negative regulation of apoptosis|negative regulation of release of cytochrome c from mitochondria|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity|protein autoprocessing|regulation of ferrochelatase activity|response to iron ion	cytosol|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferric iron binding|ferrous iron binding|ferroxidase activity|iron chaperone activity|protein binding				0						GTCCCTCCATGAGCTGCTGGC	0.498													T	71687595	T	T	71687595	4	4	159	1	0	0	0	0	0	1	0	0	6114	1291	45	5	576	5	FXN	9	71687595	Nonsense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08		71687595	69525836	62	11277											
TLE4	7091	broad.mit.edu	37	chr9	82227600	82227600	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtcaagaggctgaatgctatCtgtgcacaagtcattccttt	9	9	3	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr9:82227600C>T	uc004ald.2	+	5	1110	c.261C>T	c.(259-261)ATC>ATT	p.I87I	TLE4_uc004alc.2_Silent_p.I94I|TLE4_uc010mpr.2_5'UTR|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Silent_p.I87I|TLE4_uc010mps.2_Silent_p.I87I|TLE4_uc004alf.2_Silent_p.I32I	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						TGAATGCTATCTGTGCACAAG	0.408													T	82227600	T	T	82227600	2	4	159	1	0	0	0	0	0	0	0	1	15938	903	32	3		3	TLE4	9	82227600	Silent	SNP	C	TCGA-19-2629-01A-01D-1495-08	10540005	82227600	58985831	63	11278											
TDRD7	23424	broad.mit.edu	37	chr9	100235814	100235814	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtcaaagtaactaatatttGctctgatgggacactctact	7	8	3	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr9:100235814G>T	uc004axj.2	+	11	2210	c.1985G>T	c.(1984-1986)TGC>TTC	p.C662F	TDRD7_uc011lux.1_Missense_Mutation_p.C588F|TDRD7_uc010msp.1_5'UTR|TDRD7_uc011luy.1_Missense_Mutation_p.C11F	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	662					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				ACTAATATTTGCTCTGATGGG	0.443													T	100235814	T	T	100235814	3	4	159	1	0	0	0	0	1	0	0	0	15732	1319	46	5	2023	5	TDRD7	9	100235814	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	18008214	100235814	40977617	64	11279											
HSDL2	84263	broad.mit.edu	37	chr9	115181194	115181194	+	Frame_Shift_Del	DEL	A	-	-													tgtgcttggaatggcagaagAatttaaaggtgaaattgcag							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr9:115181194delA	uc004bga.1	+	6	647	c.554delA	c.(553-555)GAAfs	p.E185fs	HSDL2_uc011lwv.1_Frame_Shift_Del_p.E64fs|HSDL2_uc004bgb.1_Frame_Shift_Del_p.N36fs|HSDL2_uc004bgc.1_Frame_Shift_Del_p.E112fs|HSDL2_uc011lww.1_Intron	NM_032303	NP_115679	Q6YN16	HSDL2_HUMAN	hydroxysteroid dehydrogenase like 2	185						peroxisome	oxidoreductase activity|sterol binding				0						ATGGCAGAAGAATTTAAAGGT	0.279													-	115181194	-	-	115181194	7	5	159	1	0	1	0	1	0	0	0	0	7394	246	9	0	576	0	HSDL2	9	115181194	Frame_Shift_Del	DEL	A	TCGA-19-2629-01A-01D-1495-08	14945380	115181194	26032237	65	11280											
CDK5RAP2	55755	broad.mit.edu	37	chr9	123313122	123313122	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	attcctgttgcattctttccTcaaggaaatagatgcggagc	9	9	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr9:123313122T>A	uc004bkf.2	-	4	435	c.254A>T	c.(253-255)GAG>GTG	p.E85V	CDK5RAP2_uc004bkg.2_Missense_Mutation_p.E85V|CDK5RAP2_uc011lxw.1_5'UTR|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_5'UTR|CDK5RAP2_uc011lya.1_5'UTR|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.E85V	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	85					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CATTCTTTCCTCAAGGAAATA	0.383													A	123313122	A	A	123313122	3	1	159	1	0	0	0	0	1	0	0	0	3146	1551	54	5	5567	5	CDK5RAP2	9	123313122	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	8131928	123313122	17900309	66	11281											
TOR1A	1861	broad.mit.edu	37	chr9	132585088	132585088	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgattttctttgcaagatgCtgtccaaagaggttgtcgtc	10	7	1	3			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr9:132585088C>T	uc004byl.2	-	2	293	c.216G>A	c.(214-216)CAG>CAA	p.Q72Q	TOR1A_uc004bym.2_RNA|TOR1A_uc004byn.2_Silent_p.Q72Q	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	72					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)				TTGCAAGATGCTGTCCAAAGA	0.483													T	132585088	T	T	132585088	2	4	159	1	0	0	0	0	0	0	0	1	16368	796	28	3		3	TOR1A	9	132585088	Silent	SNP	C	TCGA-19-2629-01A-01D-1495-08	9271966	132585088	8628343	67	11282											
JMJD1C	221037	broad.mit.edu	37	chr10	64960280	64960282	+	In_Frame_Del	DEL	TTC	-	-													aatactggtgagtgagctggTtcttctccttttttactgcg							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr10:64960280_64960282delTTC	uc001jmn.2	-	11	5530_5532	c.5230_5232delGAA	c.(5230-5232)GAAdel	p.E1744del	JMJD1C_uc001jml.2_In_Frame_Del_p.E1525del|JMJD1C_uc001jmm.2_In_Frame_Del_p.E1456del|JMJD1C_uc010qiq.1_In_Frame_Del_p.E1562del|JMJD1C_uc009xpi.2_In_Frame_Del_p.E1562del|JMJD1C_uc009xpj.1_Intron|JMJD1C_uc009xpk.1_Intron	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1744					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGTGAGCTGGTTCTTCTCCTTTT	0.35													-	64960282	-	-	64960280	7	5	159	1	0	1	0	1	0	0	0	0	7950	1722	60	0	2454	0	JMJD1C	10	64960280	In_Frame_Del	DEL	TTC	TCGA-19-2629-01A-01D-1495-08		64960280	70574467	68	11283											
CYP2E1	1571	broad.mit.edu	37	chr10	135351261	135351261	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttgtttctcctagggcacaGtcgtagtgccaactctggac	10	11	2	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr10:135351261G>C	uc001lnj.1	+	8	1195	c.1162G>C	c.(1162-1164)GTC>CTC	p.V388L	CYP2E1_uc001lnk.1_Missense_Mutation_p.V251L|CYP2E1_uc009ybl.1_Missense_Mutation_p.V189L|CYP2E1_uc009ybm.1_Missense_Mutation_p.V42L|CYP2E1_uc001lnl.1_Missense_Mutation_p.V189L	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	388					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CTAGGGCACAGTCGTAGTGCC	0.398									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				C	135351261	C	C	135351261	3	2	159	1	0	0	0	0	1	0	0	0	4170	1029	36	5	1192	5	CYP2E1	10	135351261	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	70390981	135351261	183486	69	11284											
MUC5B	727897	broad.mit.edu	37	chr11	1257593	1257593	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccacagggtcggcttccGgcagcgtctgcctcccctgc	14	17	1	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:1257593G>A	uc009ycr.1	+	40	5063	c.4937G>A	c.(4936-4938)CGG>CAG	p.R1646Q	MUC5B_uc009yct.1_Intron|MUC5B_uc001ltb.2_Intron|MUC5B_uc001lta.2_Intron	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTCGGCTTCCGGCAGCGTCTG	0.677													A	1257593	A	A	1257593	3	1	159	1	0	0	0	0	1	0	0	0	9979	1131	39	2		2	MUC5B	11	1257593	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08		1257593	133748923	70	11285											
CHRNA10	57053	broad.mit.edu	37	chr11	3687783	3687783	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaccatggtcatagtggccaTgtagtacttccctgcaagag	11	10	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:3687783T>C	uc001lyf.2	-	5	979	c.907A>G	c.(907-909)ATG>GTG	p.M303V	CHRNA10_uc010qxt.1_Missense_Mutation_p.M97V|CHRNA10_uc010qxu.1_Missense_Mutation_p.M97V	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	303	Helical; (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	ATAGTGGCCATGTAGTACTTC	0.507													C	3687783	C	C	3687783	3	2	159	1	0	0	0	0	1	0	0	0	3382	1464	51	4	449	4	CHRNA10	11	3687783	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	2430190	3687783	131318733	71	11286											
CNGA4	1262	broad.mit.edu	37	chr11	6261617	6261617	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggtacctgggcttcgggcGtgacgcatgggtgtacccgg	17	12	0	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:6261617G>A	uc001mco.2	+	4	700	c.593G>A	c.(592-594)CGT>CAT	p.R198H	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.R158H	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	198	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCTTCGGGCGTGACGCATGG	0.547													A	6261617	A	A	6261617	3	1	159	1	0	0	0	0	1	0	0	0	3599	1145	40	1	607	1	CNGA4	11	6261617	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	2573834	6261617	128744899	72	11287											
OR10A6	390093	broad.mit.edu	37	chr11	7950020	7950020	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccaccacagataagttcaGgagaaacaggtacatgggaa	11	8	1	2	rs141585665		TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:7950020G>A	uc010rbh.1	-	1	190	c.190C>T	c.(190-192)CTG>TTG	p.L64L		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GATAAGTTCAGGAGAAACAGG	0.443													A	7950020	A	A	7950020	2	1	159	1	0	0	0	0	0	0	0	1	10894	991	35	3		3	OR10A6	11	7950020	Silent	SNP	G	TCGA-19-2629-01A-01D-1495-08	1688403	7950020	127056496	73	11288											
SYT13	57586	broad.mit.edu	37	chr11	45268002	45268002	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taatcagcaccaccaggaggCggttggcagccgggaggtag	16	10	1	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:45268002C>T	uc001myq.2	-	5	1034	c.908G>A	c.(907-909)CGC>CAC	p.R303H	SYT13_uc009yku.1_Missense_Mutation_p.R159H	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	303	C2 2.|Cytoplasmic (Potential).					transport vesicle				ovary(1)	1						CACCAGGAGGCGGTTGGCAGC	0.572													T	45268002	T	T	45268002	3	4	159	1	0	0	0	0	1	0	0	0	15466	768	27	1	380	1	SYT13	11	45268002	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	37317982	45268002	89738514	74	11289											
PSMC3	5702	broad.mit.edu	37	chr11	47446172	47446173	+	Frame_Shift_Del	DEL	TT	-	-													gctcacctgtcgtgtagaggTtttgatcacagcacacttgc							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:47446172_47446173delTT	uc001nfh.2	-	4	569_570	c.375_376delAA	c.(373-378)AAAACCfs	p.K125fs	PSMC3_uc009ylr.1_Frame_Shift_Del_p.K83fs	NM_002804	NP_002795	P17980	PRS6A_HUMAN	proteasome 26S ATPase subunit 3	125_126					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			ovary(4)	4				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CGTGTAGAGGTTTTGATCACAG	0.545													-	47446173	-	-	47446172	7	5	159	1	0	1	0	1	0	0	0	0	12687	1725	60	0	979	0	PSMC3	11	47446172	Frame_Shift_Del	DEL	TT	TCGA-19-2629-01A-01D-1495-08	2178170	47446172	87560344	75	11290											
SSRP1	6749	broad.mit.edu	37	chr11	57093935	57093937	+	In_Frame_Del	DEL	TTC	-	-													ctggggggagtactggctagTtcttcttcttcagagtcctg					rs142261788		TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:57093935_57093937delTTC	uc001njt.2	-	17	2341_2343	c.2074_2076delGAA	c.(2074-2076)GAAdel	p.E692del	TNKS1BP1_uc001njs.2_5'Flank|TNKS1BP1_uc009ymd.1_5'Flank	NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	692	Ser-rich.				DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						TACTGGCTAGTTCTTCTTCTTCA	0.552													-	57093937	-	-	57093935	7	5	159	1	0	1	0	1	0	0	0	0	15193	1722	60	0	57	0	SSRP1	11	57093935	In_Frame_Del	DEL	TTC	TCGA-19-2629-01A-01D-1495-08	9647763	57093935	77912581	76	11291											
ODZ4	26011	broad.mit.edu	37	chr11	78440577	78440577	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcatgaggttgaaggggaTggtcgggtgggtgaggctga	20	4	1	4			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:78440577T>C	uc001ozl.3	-	22	3713	c.3250A>G	c.(3250-3252)ATC>GTC	p.I1084V		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1084	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TTGAAGGGGATGGTCGGGTGG	0.567													C	78440577	C	C	78440577	3	2	159	1	0	0	0	0	1	0	0	0	10837	1464	51	4	5111	4	ODZ4	11	78440577	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	21346642	78440577	56565939	77	11292											
TMEM126B	55863	broad.mit.edu	37	chr11	85342819	85342819	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accaatggtcatagaaatcaTagaaaaaaattttgactatc	5	6	2	3			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:85342819T>C	uc001pao.2	+	3	332	c.80T>C	c.(79-81)ATA>ACA	p.I27T	TMEM126B_uc001pan.1_Missense_Mutation_p.I27T|TMEM126B_uc001pap.2_Missense_Mutation_p.I27T|TMEM126B_uc001paq.1_Missense_Mutation_p.I27T	NM_018480	NP_060950	Q8IUX1	T126B_HUMAN	transmembrane protein 126B	57						integral to membrane					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				ATAGAAATCATAGAAAAAAAT	0.353													C	85342819	C	C	85342819	3	2	159	1	0	0	0	0	1	0	0	0	16036	1406	49	4	82	4	TMEM126B	11	85342819	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	6902242	85342819	49663697	78	11293											
FOLH1B	219595	broad.mit.edu	37	chr11	89424051	89424054	+	Frame_Shift_Del	DEL	AAAC	-	-													tttgttattttttctgtaggAaacaaacaaattcagcggct							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:89424051_89424054delAAAC	uc001pda.2	+	11	1227_1230	c.701_704delAAAC	c.(700-705)GAAACAfs	p.E234fs		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	234_235					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TTTCTGTAGGAAACAAACAAATTC	0.319													-	89424054	-	-	89424051	7	5	159	1	0	1	0	1	0	0	0	0	5980	260	9	0	735	0	FOLH1B	11	89424051	Frame_Shift_Del	DEL	AAAC	TCGA-19-2629-01A-01D-1495-08	4081232	89424051	45582465	79	11294											
ARHGAP32	9743	broad.mit.edu	37	chr11	128840825	128840825	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tctccatcatcctggtggggGgcagtggtgcaggaaagcca	15	10	2	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr11:128840825G>C	uc009zcp.2	-	22	4241	c.4241C>G	c.(4240-4242)CCC>CGC	p.P1414R	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.P373R|ARHGAP32_uc001qez.2_Missense_Mutation_p.P1065R	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1414	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						CCTGGTGGGGGGCAGTGGTGC	0.592													C	128840825	C	C	128840825	3	2	159	1	0	0	0	0	1	0	0	0	881	1232	43	5	2026	5	ARHGAP32	11	128840825	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	39416774	128840825	6165691	80	11295											
KIAA1467	57613	broad.mit.edu	37	chr12	13208755	13208755	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccctggtgtcatatgtgcGcacgtctgtcttcctgctga	10	13	3	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr12:13208755G>A	uc001rbi.2	+	2	331	c.308G>A	c.(307-309)CGC>CAC	p.R103H	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	103						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TCATATGTGCGCACGTCTGTC	0.587													A	13208755	A	A	13208755	3	1	159	1	0	0	0	0	1	0	0	0	8235	1087	38	1	314	1	KIAA1467	12	13208755	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08		13208755	120643140	81	11296											
HIST4H4	121504	broad.mit.edu	37	chr12	14923761	14923761	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtttcagcgcgtacaccacAtccatggccgtgacggtctt	10	14	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr12:14923761A>G	uc001rcf.3	-	1	305	c.258T>C	c.(256-258)GAT>GAC	p.D86D	HIST4H4_uc001rce.2_RNA	NM_175054	NP_778224	P62805	H4_HUMAN	histone cluster 4, H4	86					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						CGTACACCACATCCATGGCCG	0.587											OREG0021698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	14923761	G	G	14923761	2	3	159	1	0	0	0	0	0	0	0	1	7185	214	8	4		4	HIST4H4	12	14923761	Silent	SNP	A	TCGA-19-2629-01A-01D-1495-08	1715006	14923761	118928134	82	11297											
ARID2	196528	broad.mit.edu	37	chr12	46245922	46245923	+	Frame_Shift_Del	DEL	AG	-	-													gaatggagcatctgggaaacAgaactcagaacaaatagaca							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr12:46245922_46245923delAG	uc001ros.1	+	15	4016_4017	c.4016_4017delAG	c.(4015-4017)CAGfs	p.Q1339fs	ARID2_uc001ror.2_Frame_Shift_Del_p.Q1339fs|ARID2_uc009zkg.1_Frame_Shift_Del_p.Q795fs|ARID2_uc009zkh.1_Frame_Shift_Del_p.Q966fs|ARID2_uc001rou.1_Frame_Shift_Del_p.Q673fs	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1339					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCTGGGAAACAGAACTCAGAAC	0.371													-	46245923	-	-	46245922	7	5	159	1	0	1	0	1	0	0	0	0	915	188	7	0	4074	0	ARID2	12	46245922	Frame_Shift_Del	DEL	AG	TCGA-19-2629-01A-01D-1495-08	31322161	46245922	87605973	83	11298											
FREM2	341640	broad.mit.edu	37	chr13	39425866	39425866	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accaaatttagtgtcactgaAcccaaagaacctggagagtc	8	10	1	3			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr13:39425866A>G	uc001uwv.2	+	11	7095	c.6786A>G	c.(6784-6786)GAA>GAG	p.E2262E	FREM2_uc001uww.2_Silent_p.E348E	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2262	Extracellular (Potential).|Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GTGTCACTGAACCCAAAGAAC	0.348													G	39425866	G	G	39425866	2	3	159	1	0	0	0	0	0	0	0	1	6045	40	2	4		4	FREM2	13	39425866	Silent	SNP	A	TCGA-19-2629-01A-01D-1495-08		39425866	75744012	84	11299											
AKAP11	11215	broad.mit.edu	37	chr13	42877884	42877884	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagctgagcgagagctgagcAgtaccagcctggcagccgac	14	12	0	3			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr13:42877884A>G	uc001uys.1	+	8	5177	c.5002A>G	c.(5002-5004)AGT>GGT	p.S1668G		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1668					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		AGAGCTGAGCAGTACCAGCCT	0.507													G	42877884	G	G	42877884	3	3	159	1	0	0	0	0	1	0	0	0	447	188	7	4	5024	4	AKAP11	13	42877884	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	3452018	42877884	72291994	85	11300											
RCBTB2	1102	broad.mit.edu	37	chr13	49089796	49089796	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agcctgacgaattaactgtaGttcttcttcagaacaaaggg	9	8	3	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr13:49089796G>C	uc001vch.2	-	5	495	c.124C>G	c.(124-126)CTA>GTA	p.L42V	RCBTB2_uc010tgg.1_Missense_Mutation_p.L47V|RCBTB2_uc001vci.2_Missense_Mutation_p.L18V|RCBTB2_uc010tgh.1_5'UTR|RCBTB2_uc001vcj.2_Missense_Mutation_p.L46V|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_Missense_Mutation_p.L18V	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	42							Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		ATTAACTGTAGTTCTTCTTCA	0.363													C	49089796	C	C	49089796	3	2	159	1	0	0	0	0	1	0	0	0	13172	1020	36	5	1575	5	RCBTB2	13	49089796	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	6211912	49089796	66080082	86	11301											
RNASE4	6038	broad.mit.edu	37	chr14	21167918	21167918	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggccatagcgagcactagaCgtgttgtcattgcctgtgag	14	9	1	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr14:21167918C>T	uc001vxy.3	+	2	951	c.388C>T	c.(388-390)CGT>TGT	p.R130C	RNASE4_uc001vxx.3_RNA|RNASE4_uc001vya.2_Missense_Mutation_p.R130C	NM_002937	NP_002928	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4 precursor	130					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)	1	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		GAGCACTAGACGTGTTGTCAT	0.527													T	21167918	T	T	21167918	3	4	159	1	0	0	0	0	1	0	0	0	13406	536	19	1	390	1	RNASE4	14	21167918	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08		21167918	86181622	87	11302											
GMPR2	51292	broad.mit.edu	37	chr14	24707579	24707581	+	In_Frame_Del	DEL	GAA	-	-													atgagttctgaaatggccatGaagaagtatgctgggggcgt							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr14:24707579_24707581delGAA	uc001wnr.2	+	9	1207_1209	c.825_827delGAA	c.(823-828)ATGAAG>ATG	p.K277del	GMPR2_uc001wnv.2_In_Frame_Del_p.K114del|GMPR2_uc001wns.2_In_Frame_Del_p.K277del|GMPR2_uc001wnt.2_In_Frame_Del_p.K244del|GMPR2_uc001wnu.2_In_Frame_Del_p.K241del|GMPR2_uc001wnw.2_In_Frame_Del_p.K277del|GMPR2_uc010all.2_In_Frame_Del_p.K249del|GMPR2_uc001wnx.2_In_Frame_Del_p.K295del|GMPR2_uc010tod.1_In_Frame_Del_p.K244del|GMPR2_uc010alk.1_In_Frame_Del_p.K277del|GMPR2_uc010toe.1_In_Frame_Del_p.K277del	NM_001002001	NP_001002001	Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2 isoform 2	277					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			ovary(3)	3				GBM - Glioblastoma multiforme(265;0.0181)		AAATGGCCATGAAGAAGTATGCT	0.537													-	24707581	-	-	24707579	7	5	159	1	0	1	0	1	0	0	0	0	6497	1290	45	0	909	0	GMPR2	14	24707579	In_Frame_Del	DEL	GAA	TCGA-19-2629-01A-01D-1495-08	3539661	24707579	82641961	88	11303											
DUOX2	50506	broad.mit.edu	37	chr15	45401132	45401132	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtctgtacgggagaatttgCcagggccaggccagtaatct	13	9	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr15:45401132C>T	uc010bea.2	-	12	1456	c.1253G>A	c.(1252-1254)GGC>GAC	p.G418D	DUOX2_uc001zun.2_Missense_Mutation_p.G418D	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	418	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GGAGAATTTGCCAGGGCCAGG	0.552													T	45401132	T	T	45401132	3	4	159	1	0	0	0	0	1	0	0	0	4801	739	26	3	3485	3	DUOX2	15	45401132	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08		45401132	57130260	89	11304											
ALDH1A2	8854	broad.mit.edu	37	chr15	58256142	58256142	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactacgcgcctcttggcccGctccacgcttcttctcacaa	6	19	3	0	rs137957671		TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr15:58256142G>A	uc002aex.2	-	9	1085	c.1027C>T	c.(1027-1029)CGG>TGG	p.R343W	ALDH1A2_uc002aey.2_Missense_Mutation_p.R305W|ALDH1A2_uc010ugv.1_Missense_Mutation_p.R322W|ALDH1A2_uc010ugw.1_Missense_Mutation_p.R314W|ALDH1A2_uc002aew.2_Missense_Mutation_p.R247W	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	343					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CTCTTGGCCCGCTCCACGCTT	0.527													A	58256142	A	A	58256142	3	1	159	1	0	0	0	0	1	0	0	0	491	1086	38	1	549	1	ALDH1A2	15	58256142	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	12855010	58256142	44275250	90	11305											
SCAPER	49855	broad.mit.edu	37	chr15	77059334	77059336	+	In_Frame_Del	DEL	TTC	-	-													tcaatttctctagttaactgTtcttcttcagcaatagcact							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr15:77059334_77059336delTTC	uc002bby.2	-	10	1401_1403	c.1342_1344delGAA	c.(1342-1344)GAAdel	p.E448del	SCAPER_uc002bbx.2_In_Frame_Del_p.E202del|SCAPER_uc002bbz.1_In_Frame_Del_p.E319del|SCAPER_uc002bca.1_In_Frame_Del_p.E313del|SCAPER_uc002bcb.1_In_Frame_Del_p.E454del|SCAPER_uc002bcc.1_In_Frame_Del_p.E448del	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	447	Glu-rich.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						TAGTTAACTGTTCTTCTTCAGCA	0.355													-	77059336	-	-	77059334	7	5	159	1	0	1	0	1	0	0	0	0	13878	1722	60	0	2946	0	SCAPER	15	77059334	In_Frame_Del	DEL	TTC	TCGA-19-2629-01A-01D-1495-08	18803192	77059334	25472058	91	11306											
SLC28A1	9154	broad.mit.edu	37	chr15	85476431	85476431	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctgccccttgtgccttggCcctctccaagctggtctacc	10	17	2	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr15:85476431C>T	uc002blg.2	+	13	1341	c.1139C>T	c.(1138-1140)GCC>GTC	p.A380V	SLC28A1_uc010bnb.2_Missense_Mutation_p.A380V|SLC28A1_uc010upe.1_Intron|SLC28A1_uc010upf.1_Missense_Mutation_p.A380V|SLC28A1_uc010upg.1_Missense_Mutation_p.A380V	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	380	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGTGCCTTGGCCCTCTCCAAG	0.562													T	85476431	T	T	85476431	3	4	159	1	0	0	0	0	1	0	0	0	14531	739	26	3	1252	3	SLC28A1	15	85476431	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	8417097	85476431	17054961	92	11307											
MVP	9961	broad.mit.edu	37	chr16	29855969	29855969	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttccataagaactcagcccGcatcattcgcactgctgtct	6	15	3	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr16:29855969G>A	uc002dui.2	+	11	1874	c.1790G>A	c.(1789-1791)CGC>CAC	p.R597H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc002duj.2_Missense_Mutation_p.R597H|MVP_uc010vea.1_Missense_Mutation_p.R191H	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	597					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						AACTCAGCCCGCATCATTCGC	0.617													A	29855969	A	A	29855969	3	1	159	1	0	0	0	0	1	0	0	0	9996	1087	38	1	1828	1	MVP	16	29855969	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08		29855969	60498784	93	11308											
MT1A	4489	broad.mit.edu	37	chr16	56673190	56673190	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgcaggtggctcctgcaccTgcactggctcctgcaaatgc	11	14	0	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr16:56673190T>C	uc002ejq.2	+	2	116	c.43T>C	c.(43-45)TGC>CGC	p.C15R	MT1A_uc002eji.2_Intron	NM_005946	NP_005937	P04731	MT1A_HUMAN	metallothionein 1A	15	Beta.	Divalent metal cation; cluster B.				cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding				0						CTCCTGCACCTGCACTGGCTC	0.512													C	56673190	C	C	56673190	3	2	159	1	0	0	0	0	1	0	0	0	9897	1580	55	4	49	4	MT1A	16	56673190	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	26817221	56673190	33681563	94	11309											
SLC12A3	6559	broad.mit.edu	37	chr16	56901059	56901059	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgatgggctggtggagggCgaggcaggcaccagcagcga	19	9	0	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr16:56901059C>T	uc010ccm.2	+	2	389	c.360C>T	c.(358-360)GGC>GGT	p.G120G	SLC12A3_uc002ekd.3_Silent_p.G120G|SLC12A3_uc010ccn.2_Silent_p.G119G	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	120	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TGGTGGAGGGCGAGGCAGGCA	0.652													T	56901059	T	T	56901059	2	4	159	1	0	0	0	0	0	0	0	1	14384	755	27	1		1	SLC12A3	16	56901059	Silent	SNP	C	TCGA-19-2629-01A-01D-1495-08	227869	56901059	33453694	95	11310											
CNOT1	23019	broad.mit.edu	37	chr16	58562381	58562385	+	Frame_Shift_Del	DEL	TTAGA	-	-													aactagttggaaccttacctTtagattaggagtgaatgggt							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr16:58562381_58562385delTTAGA	uc002env.2	-	44	6740_6744	c.6447_6451delTCTAA	c.(6445-6453)AATCTAAAGfs	p.N2149fs	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Frame_Shift_Del_p.N2144fs|CNOT1_uc002ent.2_Frame_Shift_Del_p.N87fs|CNOT1_uc010vik.1_Frame_Shift_Del_p.N1106fs	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2149_2151					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AACCTTACCTTTAGATTAGGAGTGA	0.4													-	58562385	-	-	58562381	7	5	159	1	0	1	0	1	0	0	0	0	3617	1850	64	0	703	0	CNOT1	16	58562381	Frame_Shift_Del	DEL	TTAGA	TCGA-19-2629-01A-01D-1495-08	1661322	58562381	31792372	96	11311											
TP53	7157	broad.mit.edu	37	chr17	7578555	7578555	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgttgagggcaggggagtaCtgtaggaagaggaaggagac	19	3	0	3			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr17:7578555C>T	uc002gim.2	-	5	570	c.376_splice	c.e5-1	p.Y126_splice	TP53_uc002gig.1_Splice_Site_p.Y126_splice|TP53_uc002gih.2_Splice_Site_p.Y126_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Splice_Site_p.Y126_splice|TP53_uc010cni.1_Splice_Site_p.Y126_splice|TP53_uc002gij.2_Splice_Site_p.Y126_splice|TP53_uc010cnj.1_Splice_Site|TP53_uc002gin.2_Splice_Site_p.Y33_splice|TP53_uc002gio.2_Splice_Site|TP53_uc010vug.1_Splice_Site_p.Y87_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(31)|p.0?(7)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGGAGTACTGTAGGAAGA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578555	T	T	7578555	5	4	159	1	0	0	0	0	0	0	1	0	16378	579	20	3	923	3	TP53	17	7578555	Splice_Site	SNP	C	TCGA-19-2629-01A-01D-1495-08		7578555	73616655	97	11312											
MYH4	4622	broad.mit.edu	37	chr17	10350506	10350506	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaggtcatcttggcctctgaTggcatcatccaaatgtagct	9	10	4	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr17:10350506T>A	uc002gmn.2	-	35	5104	c.4993A>T	c.(4993-4995)ATC>TTC	p.I1665F	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1665	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TGGCCTCTGATGGCATCATCC	0.468													A	10350506	A	A	10350506	3	1	159	1	0	0	0	0	1	0	0	0	10037	1464	51	5	850	5	MYH4	17	10350506	Missense_Mutation	SNP	T	TCGA-19-2629-01A-01D-1495-08	2771951	10350506	70844704	98	11313											
MYH1	4619	broad.mit.edu	37	chr17	10395868	10395868	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ctgcggaatttggagaggttGacgttggattgttcctcctg	14	7	0	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr17:10395868G>T	uc002gmo.2	-	40	5779	c.5685C>A	c.(5683-5685)GTC>GTA	p.V1895V	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1895	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TGGAGAGGTTGACGTTGGATT	0.473													T	10395868	T	T	10395868	2	4	159	1	0	0	0	0	0	0	0	1	10029	1277	45	5		5	MYH1	17	10395868	Silent	SNP	G	TCGA-19-2629-01A-01D-1495-08	45362	10395868	70799342	99	11314											
DNAH9	1770	broad.mit.edu	37	chr17	11757746	11757749	+	Splice_Site	DEL	GTGA	-	-													ccatcaaagccaagatcgctGtgagtgaccccagagcccct							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr17:11757746_11757749delGTGA	uc002gne.2	+	50	10001	c.9933_splice	c.e50+1	p.A3311_splice	DNAH9_uc010coo.2_Splice_Site_p.A2605_splice	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAAGATCGCTGTGAGTGACCCCAG	0.515													-	11757749	-	-	11757746	8	5	159	1	0	1	0	1	0	0	1	0	4608	1391	48	0	10132	0	DNAH9	17	11757746	Splice_Site	DEL	GTGA	TCGA-19-2629-01A-01D-1495-08	1361878	11757746	69437464	100	11315											
FAM83G	644815	broad.mit.edu	37	chr17	18906958	18906958	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatggtgtcgggccagcccaGgtccagctgcgggatggagc	18	11	0	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr17:18906958G>A	uc002guw.2	-	2	564	c.397C>T	c.(397-399)CTG>TTG	p.L133L	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	133										ovary(1)|central_nervous_system(1)	2						GGCCAGCCCAGGTCCAGCTGC	0.701													A	18906958	A	A	18906958	2	1	159	1	0	0	0	0	0	0	0	1	5639	991	35	3		3	FAM83G	17	18906958	Silent	SNP	G	TCGA-19-2629-01A-01D-1495-08	7149212	18906958	62288252	101	11316											
ACACA	31	broad.mit.edu	37	chr17	35564699	35564701	+	In_Frame_Del	DEL	GGA	-	-													atgccatagtggttgaggttGgaggagaaggacattctaaa							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr17:35564699_35564701delGGA	uc002hnm.2	-	31	3801_3803	c.3610_3612delTCC	c.(3610-3612)TCCdel	p.S1204del	ACACA_uc002hnk.2_In_Frame_Del_p.S1126del|ACACA_uc002hnl.2_In_Frame_Del_p.S1146del|ACACA_uc002hnn.2_In_Frame_Del_p.S1204del|ACACA_uc002hno.2_In_Frame_Del_p.S1241del|ACACA_uc010cuy.2_5'Flank	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1204					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GGTTGAGGTTGGAGGAGAAGGAC	0.473													-	35564701	-	-	35564699	7	5	159	1	0	1	0	1	0	0	0	0	106	1335	47	0	3532	0	ACACA	17	35564699	In_Frame_Del	DEL	GGA	TCGA-19-2629-01A-01D-1495-08	16657741	35564699	45630511	102	11317											
SGSH	6448	broad.mit.edu	37	chr17	78185892	78185892	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaggctcacgtaggcctcGctgacttggccccagcgttt	13	13	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr17:78185892G>A	uc002jxz.3	-	7	1014	c.927C>T	c.(925-927)AGC>AGT	p.S309S	SGSH_uc002jya.3_Silent_p.S106S|SGSH_uc002jxy.2_3'UTR|SGSH_uc010wue.1_3'UTR	NM_000199	NP_000190	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase precursor	309					proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CGTAGGCCTCGCTGACTTGGC	0.602													A	78185892	A	A	78185892	2	1	159	1	0	0	0	0	0	0	0	1	14221	1078	38	1		1	SGSH	17	78185892	Silent	SNP	G	TCGA-19-2629-01A-01D-1495-08	42621193	78185892	3009318	103	11318											
SETBP1	26040	broad.mit.edu	37	chr18	42533090	42533090	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgtggactcatgcacgaaaaGatactctggcagtggcgggg	15	8	2	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr18:42533090G>C	uc010dni.2	+	4	4081	c.3785G>C	c.(3784-3786)AGA>ACA	p.R1262T		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1262						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TGCACGAAAAGATACTCTGGC	0.537									Schinzel-Giedion_syndrome				C	42533090	C	C	42533090	3	2	159	1	0	0	0	0	1	0	0	0	14129	942	33	5	3988	5	SETBP1	18	42533090	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08		42533090	35544158	104	11319											
MYO5B	4645	broad.mit.edu	37	chr18	47479673	47479674	+	Frame_Shift_Del	DEL	TC	-	-													tctgctcttcatacaccgtgTctctgtttttctccagaaaa							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr18:47479673_47479674delTC	uc002leb.2	-	14	1996_1997	c.1708_1709delGA	c.(1708-1710)GACfs	p.D570fs	MYO5B_uc002lec.1_Frame_Shift_Del_p.D569fs	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	570	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		ATACACCGTGTCTCTGTTTTTC	0.52													-	47479674	-	-	47479673	7	5	159	1	0	1	0	1	0	0	0	0	10079	1667	58	0	3945	0	MYO5B	18	47479673	Frame_Shift_Del	DEL	TC	TCGA-19-2629-01A-01D-1495-08	4946583	47479673	30597575	105	11320											
ZNF407	55628	broad.mit.edu	37	chr18	72343319	72343319	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agatgaaacagggaaggagaCctttctgagtgactgcacag	13	7	1	5			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr18:72343319C>A	uc002llw.2	+	1	401	c.344C>A	c.(343-345)ACC>AAC	p.T115N	ZNF407_uc010xfc.1_Missense_Mutation_p.T115N|ZNF407_uc010dqu.1_Missense_Mutation_p.T115N|ZNF407_uc002llu.2_Missense_Mutation_p.T114N	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGGAAGGAGACCTTTCTGAGT	0.443													A	72343319	A	A	72343319	3	1	159	1	0	0	0	0	1	0	0	0	17884	507	18	5	346	5	ZNF407	18	72343319	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	24863646	72343319	5733929	106	11321											
ELANE	1991	broad.mit.edu	37	chr19	855979	855979	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggactccggcagccccttgGtctgcaacgggctaatccac	12	15	1	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr19:855979G>A	uc002lqb.2	+	5	657	c.619G>A	c.(619-621)GTC>ATC	p.V207I		NM_001972	NP_001963	P08246	ELNE_HUMAN	neutrophil elastase preproprotein	207	Peptidase S1.				cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			pancreas(1)	1					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CAGCCCCTTGGTCTGCAACGG	0.657									Kostmann_syndrome				A	855979	A	A	855979	3	1	159	1	0	0	0	0	1	0	0	0	5048	1261	44	3	637	3	ELANE	19	855979	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08		855979	58273004	107	11322											
TMIGD2	126259	broad.mit.edu	37	chr19	4298041	4298042	+	Frame_Shift_Del	DEL	TA	-	-													tcctccaactcaggaatctcTacggccgcccagcacacgta							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr19:4298041_4298042delTA	uc002lzx.1	-	2	393_394	c.347_348delTA	c.(346-348)GTAfs	p.V116fs	TMIGD2_uc010dtv.1_Frame_Shift_Del_p.V116fs	NM_144615	NP_653216	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain	116	Extracellular (Potential).|Ig-like.					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGAATCTCTACGGCCGCCCA	0.653													-	4298042	-	-	4298041	7	5	159	1	0	1	0	1	0	0	0	0	16228	1509	53	0	516	0	TMIGD2	19	4298041	Frame_Shift_Del	DEL	TA	TCGA-19-2629-01A-01D-1495-08	3442062	4298041	54830942	108	11323											
TRIP10	9322	broad.mit.edu	37	chr19	6751206	6751206	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgtgcccacctcctacctccGagtcacgctcaattgaaccc	6	19	2	1	rs139028261		TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr19:6751206G>A	uc002mfs.2	+	15	1856	c.1790G>A	c.(1789-1791)CGA>CAA	p.R597Q	TRIP10_uc010dux.1_Missense_Mutation_p.E551K|TRIP10_uc002mfr.2_Missense_Mutation_p.R541Q|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.R360Q	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	597	Interaction with PDE6G (By similarity).|SH3.|Required for podosome formation.|Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.|Interaction with DNM1 and WASL.|Required for interaction with FASLG and localization to lysosomes.|Interaction with WAS.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						TCCTACCTCCGAGTCACGCTC	0.612													A	6751206	A	A	6751206	3	1	159	1	0	0	0	0	1	0	0	0	16551	1058	37	2	1676	2	TRIP10	19	6751206	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	2453165	6751206	52377777	109	11324											
C19orf43	79002	broad.mit.edu	37	chr19	12841881	12841881	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtcacctttacttgttaatAcctgtggaaaggggatacgg	11	8	1	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr19:12841881A>G	uc002muu.2	-	3	483	c.425T>C	c.(424-426)GTA>GCA	p.V142A		NM_024038	NP_076943	Q9BQ61	CS043_HUMAN	hypothetical protein MGC2803	142											0						ACTTGTTAATACCTGTGGAAA	0.547													G	12841881	G	G	12841881	3	3	159	1	0	0	0	0	1	0	0	0	1926	405	14	4	109	4	C19orf43	19	12841881	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	6090675	12841881	46287102	110	11325											
CYP4F12	66002	broad.mit.edu	37	chr19	15807863	15807863	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgagggcgggctttggctgCgggtggagcccctgaatgta	18	10	0	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr19:15807863C>T	uc002nbl.2	+	13	1604	c.1543C>T	c.(1543-1545)CGG>TGG	p.R515W		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GCTTTGGCTGCGGGTGGAGCC	0.567													T	15807863	T	T	15807863	3	4	159	1	0	0	0	0	1	0	0	0	4187	759	27	1	1589	1	CYP4F12	19	15807863	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	2965982	15807863	43321120	111	11326											
USP29	57663	broad.mit.edu	37	chr19	57641232	57641232	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aattaaatgccactttgaatActgggaaagaatgtggggat	11	4	0	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr19:57641232A>G	uc002qny.2	+	4	1545	c.1189A>G	c.(1189-1191)ACT>GCT	p.T397A		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	397					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CACTTTGAATACTGGGAAAGA	0.383													G	57641232	G	G	57641232	3	3	159	1	0	0	0	0	1	0	0	0	17056	391	14	4	1191	4	USP29	19	57641232	Missense_Mutation	SNP	A	TCGA-19-2629-01A-01D-1495-08	41833369	57641232	1487751	112	11327											
MYH7B	57644	broad.mit.edu	37	chr20	33572918	33572918	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctgggaagctggcatccgCggatattgacagctgtgagt	14	9	1	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr20:33572918C>T	uc002xbi.1	+	11	1009	c.917C>T	c.(916-918)GCG>GTG	p.A306V		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	264	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CTGGCATCCGCGGATATTGAC	0.642													T	33572918	T	T	33572918	3	4	159	1	0	0	0	0	1	0	0	0	10040	768	27	1	959	1	MYH7B	20	33572918	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08		33572918	29452602	113	11328											
PTPRT	11122	broad.mit.edu	37	chr20	40911144	40911144	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cataccttttgtagccagacGaacacagttgattttggtct	8	9	1	2			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr20:40911144G>A	uc002xkg.2	-	13	2345	c.2161C>T	c.(2161-2163)CGT>TGT	p.R721C	PTPRT_uc010ggj.2_Missense_Mutation_p.R721C	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	721	Extracellular (Potential).|Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GTAGCCAGACGAACACAGTTG	0.348													A	40911144	A	A	40911144	3	1	159	1	0	0	0	0	1	0	0	0	12812	1058	37	2	2301	2	PTPRT	20	40911144	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	7338226	40911144	22114376	114	11329											
KCNE1	3753	broad.mit.edu	37	chr21	35821746	35821746	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttggagcggatgtagctcaGcatgatgcccagggtgaaga	15	8	1	3			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr21:35821746G>T	uc010gmp.2	-	2	617	c.187C>A	c.(187-189)CTG>ATG	p.L63M	KCNE1_uc002ytz.2_Missense_Mutation_p.L63M|KCNE1_uc010gmq.2_Missense_Mutation_p.L63M|KCNE1_uc010gmr.2_Missense_Mutation_p.L63M|KCNE1_uc010gms.2_Missense_Mutation_p.L63M|KCNE1_uc002yua.2_RNA	NM_001127670	NP_001121142	P15382	KCNE1_HUMAN	potassium voltage-gated channel, Isk-related	63	Helical; (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound	lysosome	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(2)	2					Indapamide(DB00808)	ATGTAGCTCAGCATGATGCCC	0.592													T	35821746	T	T	35821746	3	4	159	1	0	0	0	0	1	0	0	0	8021	962	34	5	206	5	KCNE1	21	35821746	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08		35821746	12308149	115	11330											
KRTAP10-2	386679	broad.mit.edu	37	chr21	45971183	45971183	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcctggcagcaggggctggaCacacagctcactggggtgca	16	12	1	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr21:45971183C>G	uc002zfi.1	-	1	206	c.159G>C	c.(157-159)GTG>GTC	p.V53V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	53	22 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)	1						AGGGGCTGGACACACAGCTCA	0.697													G	45971183	G	G	45971183	2	3	159	1	0	0	0	0	0	0	0	1	8509	465	17	5		5	KRTAP10-2	21	45971183	Silent	SNP	C	TCGA-19-2629-01A-01D-1495-08	10149437	45971183	2158712	116	11331											
OSBP2	23762	broad.mit.edu	37	chr22	31137202	31137202	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accatcaacctgtccaccgcGcacattgacacggaggactc	8	16	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr22:31137202G>A	uc003aiy.1	+	2	803	c.699G>A	c.(697-699)GCG>GCA	p.A233A	OSBP2_uc011ala.1_Silent_p.A68A|OSBP2_uc010gwc.1_Silent_p.A60A|OSBP2_uc003aix.1_Silent_p.A233A|OSBP2_uc011alb.1_Silent_p.A233A|OSBP2_uc003aiz.1_Silent_p.A233A	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	233	PH.				lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						TGTCCACCGCGCACATTGACA	0.557													A	31137202	A	A	31137202	2	1	159	1	0	0	0	0	0	0	0	1	11274	1074	38	1		1	OSBP2	22	31137202	Silent	SNP	G	TCGA-19-2629-01A-01D-1495-08		31137202	20167364	117	11332											
TMPRSS6	164656	broad.mit.edu	37	chr22	37492125	37492125	+	Frame_Shift_Del	DEL	C	-	-													agaagaagcaggtgaggggtCcctccctaaggcaggcagaa							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr22:37492125delC	uc003aqs.1	-	5	551	c.437delG	c.(436-438)GGAfs	p.G146fs	TMPRSS6_uc003aqt.1_Frame_Shift_Del_p.G137fs|TMPRSS6_uc003aqu.2_Frame_Shift_Del_p.G137fs	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	146	Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						GGTGAGGGGTCCCTCCCTAAG	0.567													-	37492125	-	-	37492125	7	5	159	1	0	1	0	1	0	0	0	0	16248	855	30	0	2054	0	TMPRSS6	22	37492125	Frame_Shift_Del	DEL	C	TCGA-19-2629-01A-01D-1495-08	6354923	37492125	13812441	118	11333											
CYTH4	27128	broad.mit.edu	37	chr22	37707507	37707507	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccctgtaggacaaggagcCacggggaattatacctcttg	11	10	1	0			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr22:37707507C>T	uc003arf.2	+	11	1012	c.896C>T	c.(895-897)CCA>CTA	p.P299L	CYTH4_uc011amw.1_Missense_Mutation_p.P242L|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	299	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						GACAAGGAGCCACGGGGAATT	0.582													T	37707507	T	T	37707507	3	4	159	1	0	0	0	0	1	0	0	0	4206	594	21	3	938	3	CYTH4	22	37707507	Missense_Mutation	SNP	C	TCGA-19-2629-01A-01D-1495-08	215382	37707507	13597059	119	11334											
DDX17	10521	broad.mit.edu	37	chr22	38890068	38890069	+	Frame_Shift_Del	DEL	TT	-	-													tcagatcatcacagcgtctcTttgtctccacaaatattatt							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr22:38890068_38890069delTT	uc003avy.3	-	9	1385_1386	c.1282_1283delAA	c.(1282-1284)AAGfs	p.K428fs	DDX17_uc003avx.3_Frame_Shift_Del_p.K428fs|DDX17_uc011anu.1_Frame_Shift_Del_p.K341fs	NM_001098504	NP_001091974	Q92841	DDX17_HUMAN	DEAD box polypeptide 17 isoform 3	349	Helicase C-terminal.				RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)					ACAGCGTCTCTTTGTCTCCACA	0.386													-	38890069	-	-	38890068	7	5	159	1	0	1	0	1	0	0	0	0	4344	1609	56	0	932	0	DDX17	22	38890068	Frame_Shift_Del	DEL	TT	TCGA-19-2629-01A-01D-1495-08	1182561	38890068	12414498	120	11335											
MCHR1	2847	broad.mit.edu	37	chr22	41077826	41077826	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtgctctgtgagacgttccGcaaacgcttggtcctgtcgg	13	12	1	1			TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chr22:41077826G>A	uc003ayz.2	+	2	1431	c.1163G>A	c.(1162-1164)CGC>CAC	p.R388H	MCHR1_uc003aza.2_Missense_Mutation_p.R277H|uc003azb.1_RNA	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	388	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0						GAGACGTTCCGCAAACGCTTG	0.572													A	41077826	A	A	41077826	3	1	159	1	0	0	0	0	1	0	0	0	9382	1087	38	1	1169	1	MCHR1	22	41077826	Missense_Mutation	SNP	G	TCGA-19-2629-01A-01D-1495-08	2187758	41077826	10226740	121	11336											
ATRX	546	broad.mit.edu	37	chrX	76939674	76939675	+	Frame_Shift_Del	DEL	TT	-	-													ttggctgtggtctcaatcagTttttttgccttcttaatcat							TCGA-19-2629-01A-01D-1495-08	TCGA-19-2629-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	56ffaa35-814c-4c0b-b3c6-d4514d34fec2	99337ac4-6bcf-4258-81aa-23c5f807ac5f	g.chrX:76939674_76939675delTT	uc004ecp.3	-	9	1305_1306	c.1073_1074delAA	c.(1072-1074)AAAfs	p.K358fs	ATRX_uc004ecq.3_Frame_Shift_Del_p.K320fs|ATRX_uc004eco.3_Frame_Shift_Del_p.K143fs|ATRX_uc004ecr.2_Frame_Shift_Del_p.K319fs|ATRX_uc010nlx.1_Frame_Shift_Del_p.K358fs|ATRX_uc010nly.1_Frame_Shift_Del_p.K303fs	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	358					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCTCAATCAGTTTTTTTGCCTT	0.366			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						-	76939675	-	-	76939674	7	5	159	1	0	1	0	1	0	0	0	0	1208	1722	60	0	6512	0	ATRX	23	76939674	Frame_Shift_Del	DEL	TT	TCGA-19-2629-01A-01D-1495-08		76939674	78330886	122	11337											
SEPN1	57190	broad.mit.edu	37	chr1	26140414	26140414	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gactgtcctggaaagttcgcCcatcctcaccctgctcaacg	8	16	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr1:26140414C>A	uc010oer.1	+	14	1485	c.1430C>A	c.(1429-1431)CCC>CAC	p.P477H	SEPN1_uc010oes.1_Missense_Mutation_p.P443H	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	477						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		GAAAGTTCGCCCATCCTCACC	0.612													A	26140414	A	A	26140414	3	1	160	1	0	0	0	0	1	0	0	0	14056	623	22	5	1472	5	SEPN1	1	26140414	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08		26140414	223110207	1	11338											
NTNG1	22854	broad.mit.edu	37	chr1	107867040	107867040	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacttggaaggagtatcccaAgcctctccaggttaacatca	8	12	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr1:107867040A>G	uc001dvh.3	+	3	1101	c.383A>G	c.(382-384)AAG>AGG	p.K128R	NTNG1_uc001dvf.3_Missense_Mutation_p.K128R|NTNG1_uc010out.1_Missense_Mutation_p.K128R|NTNG1_uc001dvc.3_Missense_Mutation_p.K128R|NTNG1_uc001dvd.1_Missense_Mutation_p.K128R	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	128	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GAGTATCCCAAGCCTCTCCAG	0.478													G	107867040	G	G	107867040	3	3	160	1	0	0	0	0	1	0	0	0	10704	72	3	4	389	4	NTNG1	1	107867040	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08	81726626	107867040	141383581	2	11339											
AKNAD1	254268	broad.mit.edu	37	chr1	109395162	109395162	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaataatttgatttaagactTcaaggccatccttttttgag	6	6	1	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr1:109395162T>C	uc001dwa.2	-	2	394	c.125A>G	c.(124-126)GAA>GGA	p.E42G	AKNAD1_uc010ovb.1_Intron|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	42										ovary(3)	3						ATTTAAGACTTCAAGGCCATC	0.408													C	109395162	C	C	109395162	3	2	160	1	0	0	0	0	1	0	0	0	464	1783	62	4	2445	4	AKNAD1	1	109395162	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08	1528122	109395162	139855459	3	11340											
IFI16	3428	broad.mit.edu	37	chr1	159015232	159015232	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcagatgcctccatcaacacCaagcagcagtttcttaacca	5	14	3	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr1:159015232C>A	uc010pis.1	+	7	1486	c.1307C>A	c.(1306-1308)CCA>CAA	p.P436Q	IFI16_uc001ftg.2_Intron|IFI16_uc001fth.2_Intron|IFI16_uc010pit.1_Missense_Mutation_p.P91Q	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	492					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					CCATCAACACCAAGCAGCAGT	0.488													A	159015232	A	A	159015232	3	1	160	1	0	0	0	0	1	0	0	0	7511	609	21	5		5	IFI16	1	159015232	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	49620070	159015232	90235389	4	11341											
IGSF9	57549	broad.mit.edu	37	chr1	159897140	159897140	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacatcagggatgttcacaGcagagtggcctgttcggggt	14	9	3	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr1:159897140G>A	uc001fur.2	-	21	3733	c.3535C>T	c.(3535-3537)CTG>TTG	p.L1179L	IGSF9_uc001fuq.2_Silent_p.L1163L|CCDC19_uc001ful.2_5'Flank|TAGLN2_uc001fun.1_5'Flank|TAGLN2_uc001fuo.1_5'Flank|TAGLN2_uc010piy.1_5'Flank|IGSF9_uc001fup.2_Silent_p.L325L	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	1179	PDZ-binding (By similarity).|Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GATGTTCACAGCAGAGTGGCC	0.607													A	159897140	A	A	159897140	2	1	160	1	0	0	0	0	0	0	0	1	7605	962	34	3		3	IGSF9	1	159897140	Silent	SNP	G	TCGA-19-2631-01A-01D-1353-08	881908	159897140	89353481	5	11342											
FMO3	2328	broad.mit.edu	37	chr1	171077238	171077238	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggactaaaccactttaaagGcaaatgcttccacagcaggg	9	10	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr1:171077238G>A	uc001ghi.2	+	5	614	c.503G>A	c.(502-504)GGC>GAC	p.G168D	FMO3_uc001ghh.2_Missense_Mutation_p.G168D|FMO3_uc010pmb.1_Missense_Mutation_p.G148D|FMO3_uc010pmc.1_Missense_Mutation_p.G105D	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	168					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CACTTTAAAGGCAAATGCTTC	0.423													A	171077238	A	A	171077238	3	1	160	1	0	0	0	0	1	0	0	0	5956	1203	42	3	517	3	FMO3	1	171077238	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	11180098	171077238	78173383	6	11343											
OR14A16	284532	broad.mit.edu	37	chr1	247978223	247978223	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagtgtagaacacagaaattAcagcatccaaaatagaagga	8	6	0	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr1:247978223A>G	uc001idm.1	-	1	809	c.809T>C	c.(808-810)GTA>GCA	p.V270A		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	270	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACAGAAATTACAGCATCCAA	0.413													G	247978223	G	G	247978223	3	3	160	1	0	0	0	0	1	0	0	0	10945	391	14	4	124	4	OR14A16	1	247978223	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08	76900985	247978223	1272398	7	11344											
CTNNA2	1496	broad.mit.edu	37	chr2	80874750	80874750	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatccaggcagctaaaaaccTgatgaatgctgttgtcctca	8	10	1	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr2:80874750T>C	uc010ysh.1	+	18	2620	c.2615T>C	c.(2614-2616)CTG>CCG	p.L872P	CTNNA2_uc010yse.1_Missense_Mutation_p.L824P|CTNNA2_uc010ysf.1_Missense_Mutation_p.L824P|CTNNA2_uc010ysg.1_Missense_Mutation_p.L779P|CTNNA2_uc010ysi.1_Missense_Mutation_p.L456P|CTNNA2_uc010ysj.1_Missense_Mutation_p.L153P	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	872					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GCTAAAAACCTGATGAATGCT	0.468													C	80874750	C	C	80874750	3	2	160	1	0	0	0	0	1	0	0	0	4013	1580	55	4	2329	4	CTNNA2	2	80874750	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08		80874750	162324623	8	11345											
RGPD4	285190	broad.mit.edu	37	chr2	108455335	108455335	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgcagaattgctttgtaaaaAtgatgttactgatggaagag	11	3	0	4			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr2:108455335A>T	uc010ywk.1	+	4	402	c.320A>T	c.(319-321)AAT>ATT	p.N107I	RGPD4_uc002tdu.2_5'UTR	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	107					intracellular transport		binding			skin(2)	2						CTTTGTAAAAATGATGTTACT	0.333													T	108455335	T	T	108455335	3	4	160	1	0	0	0	0	1	0	0	0	13288	101	4	5	334	5	RGPD4	2	108455335	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08	27580585	108455335	134744038	9	11346											
SCN9A	6335	broad.mit.edu	37	chr2	167159653	167159653	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttatgctttctaatgtttcaTtattttcaagtgaatttcga	5	5	3	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr2:167159653T>C	uc010fpl.2	-	7	1189	c.848A>G	c.(847-849)AAT>AGT	p.N283S	SCN9A_uc002udr.1_Missense_Mutation_p.N154S|SCN9A_uc002uds.1_Missense_Mutation_p.N154S|SCN9A_uc002udt.1_Missense_Mutation_p.N154S	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	283	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TAATGTTTCATTATTTTCAAG	0.338													C	167159653	C	C	167159653	3	2	160	1	0	0	0	0	1	0	0	0	13925	1493	52	4	5169	4	SCN9A	2	167159653	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08	58704318	167159653	76039720	10	11347											
ZSWIM2	151112	broad.mit.edu	37	chr2	187713851	187713851	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agaggccttatagcctcggcGaagcatgctgggtgcgggcg	17	10	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr2:187713851G>T	uc002upu.1	-	1	47	c.7C>A	c.(7-9)CGC>AGC	p.R3S		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	3					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TAGCCTCGGCGAAGCATGCTG	0.642													T	187713851	T	T	187713851	3	4	160	1	0	0	0	0	1	0	0	0	18238	1058	37	5	1930	5	ZSWIM2	2	187713851	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	20554198	187713851	55485522	11	11348											
FAM126B	285172	broad.mit.edu	37	chr2	201846441	201846441	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctttatccttggctgaaCgcccagttgctactttcctt	6	12	1	1	rs138872845		TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr2:201846441C>T	uc002uws.3	-	12	1333	c.1145G>A	c.(1144-1146)CGT>CAT	p.R382H	FAM126B_uc002uwu.2_Missense_Mutation_p.R356H|FAM126B_uc002uwv.2_Missense_Mutation_p.R382H	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	382						intracellular				ovary(1)	1						CTTGGCTGAACGCCCAGTTGC	0.493													T	201846441	T	T	201846441	3	4	160	1	0	0	0	0	1	0	0	0	5430	536	19	1	451	1	FAM126B	2	201846441	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	14132590	201846441	41352932	12	11349											
ZDBF2	57683	broad.mit.edu	37	chr2	207176262	207176262	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcatcttgtttacaacaacGtgagagaatgatgactcggc	9	9	2	4			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr2:207176262G>A	uc002vbp.2	+	5	7260	c.7010G>A	c.(7009-7011)CGT>CAT	p.R2337H		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2337							nucleic acid binding|zinc ion binding			ovary(3)	3						TTACAACAACGTGAGAGAATG	0.428													A	207176262	A	A	207176262	3	1	160	1	0	0	0	0	1	0	0	0	17596	1145	40	1	7020	1	ZDBF2	2	207176262	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	5329821	207176262	36023111	13	11350											
CHRND	1144	broad.mit.edu	37	chr2	233394744	233394744	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccgccaggacatcaccttcTacctcatcatccgccgcaag	7	18	4	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr2:233394744T>C	uc002vsw.2	+	7	719	c.715T>C	c.(715-717)TAC>CAC	p.Y239H	CHRND_uc010zmg.1_Missense_Mutation_p.Y224H|CHRND_uc010fyc.2_Missense_Mutation_p.Y112H|CHRND_uc010zmh.1_Intron	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	239	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		CATCACCTTCTACCTCATCAT	0.612													C	233394744	C	C	233394744	3	2	160	1	0	0	0	0	1	0	0	0	3394	1522	53	4	741	4	CHRND	2	233394744	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08	26218482	233394744	9804629	14	11351											
ATG4B	23192	broad.mit.edu	37	chr2	242592988	242592988	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctgcggtgtggacagatgatCtttgcccaagccctggtgtg	14	10	1	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr2:242592988C>G	uc002wbv.2	+	4	349	c.246C>G	c.(244-246)ATC>ATG	p.I82M	ATG4B_uc002wbu.2_Missense_Mutation_p.I8M|ATG4B_uc002wbw.2_Missense_Mutation_p.I82M|ATG4B_uc010zox.1_Missense_Mutation_p.I68M|ATG4B_uc010zoy.1_Missense_Mutation_p.I8M|ATG4B_uc010fzp.2_Missense_Mutation_p.I82M|ATG4B_uc010zoz.1_Missense_Mutation_p.I8M	NM_013325	NP_037457	Q9Y4P1	ATG4B_HUMAN	APG4 autophagy 4 homolog B isoform a	82					autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)		GACAGATGATCTTTGCCCAAG	0.642													G	242592988	G	G	242592988	3	3	160	1	0	0	0	0	1	0	0	0	1097	903	32	5	260	5	ATG4B	2	242592988	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	9198244	242592988	606385	15	11352											
ZFYVE20	64145	broad.mit.edu	37	chr3	15123959	15123959	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcgtgtccttgcagtgtgtaCagcagcggatccggtcatcg	14	11	1	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr3:15123959C>A	uc003bzm.1	-	9	1369	c.755G>T	c.(754-756)TGT>TTT	p.C252F	ZFYVE20_uc010hek.1_Missense_Mutation_p.C252F|ZFYVE20_uc011avn.1_Intron	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	252	FYVE-type.|Necessary for the correct targeting to endosomes.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						GCAGTGTGTACAGCAGCGGAT	0.572													A	15123959	A	A	15123959	3	1	160	1	0	0	0	0	1	0	0	0	17663	478	17	5	1623	5	ZFYVE20	3	15123959	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08		15123959	182898471	16	11353											
FLNB	2317	broad.mit.edu	37	chr3	58141766	58141766	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgccggtcatcgcaccctcCgacgacgcccgccgcctcac	10	21	2	0	rs113304692		TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr3:58141766C>T	uc003djj.2	+	41	7017	c.6852C>T	c.(6850-6852)TCC>TCT	p.S2284S	FLNB_uc010hne.2_Silent_p.S2315S|FLNB_uc003djk.2_Silent_p.S2273S|FLNB_uc010hnf.2_Silent_p.S2260S|FLNB_uc003djl.2_Silent_p.S2104S|FLNB_uc003djm.2_Silent_p.S2091S	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2284	Filamin 22.|Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TCGCACCCTCCGACGACGCCC	0.587													T	58141766	T	T	58141766	2	4	160	1	0	0	0	0	0	0	0	1	5934	639	23	2		2	FLNB	3	58141766	Silent	SNP	C	TCGA-19-2631-01A-01D-1353-08	43017807	58141766	139880664	17	11354											
ROBO1	6091	broad.mit.edu	37	chr3	78711202	78711202	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggttgtggaggtgcagaaCagcatttcccagctctctct	13	10	2	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr3:78711202C>T	uc003dqe.2	-	15	2237	c.2029G>A	c.(2029-2031)GTT>ATT	p.V677I	ROBO1_uc003dqb.2_Missense_Mutation_p.V638I|ROBO1_uc003dqc.2_Missense_Mutation_p.V641I|ROBO1_uc003dqd.2_Missense_Mutation_p.V641I|ROBO1_uc010hoh.2_5'UTR|ROBO1_uc011bgl.1_Missense_Mutation_p.V249I|ROBO1_uc003dqf.1_Missense_Mutation_p.V356I	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	677	Extracellular (Potential).|Fibronectin type-III 2.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AGGTGCAGAACAGCATTTCCC	0.483													T	78711202	T	T	78711202	3	4	160	1	0	0	0	0	1	0	0	0	13513	478	17	3	2994	3	ROBO1	3	78711202	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	20569436	78711202	119311228	18	11355											
OR5H1	26341	broad.mit.edu	37	chr3	97851558	97851558	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggacatggaagaggaaaatgCaacattgctgacagagtttg	13	5	0	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr3:97851558C>G	uc011bgt.1	+	1	17	c.17C>G	c.(16-18)GCA>GGA	p.A6G		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GAGGAAAATGCAACATTGCTG	0.393													G	97851558	G	G	97851558	3	3	160	1	0	0	0	0	1	0	0	0	11159	710	25	5	19	5	OR5H1	3	97851558	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	19140356	97851558	100170872	19	11356											
CEP70	80321	broad.mit.edu	37	chr3	138216906	138216906	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tagatcattagtaaatgcctGaaatgctgggaaaaattcct	8	6	1	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr3:138216906G>A	uc003esl.2	-	17	1897	c.1699C>T	c.(1699-1701)CAG>TAG	p.Q567*	CEP70_uc011bmk.1_Nonsense_Mutation_p.Q547*|CEP70_uc011bml.1_Nonsense_Mutation_p.Q549*|CEP70_uc011bmm.1_Nonsense_Mutation_p.Q415*	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	567					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						GTAAATGCCTGAAATGCTGGG	0.343													A	138216906	A	A	138216906	4	1	160	1	0	0	0	0	0	1	0	0	3259	1299	45	3	102	3	CEP70	3	138216906	Nonsense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	40365348	138216906	59805524	20	11357											
NAALADL2	254827	broad.mit.edu	37	chr3	174814645	174814645	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	caggacactcacagtacttaGacaatgatgaccttcaagcc	7	12	2	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr3:174814645G>A	uc003fit.2	+	2	196	c.109G>A	c.(109-111)GAC>AAC	p.D37N	NAALADL2_uc003fiu.1_Missense_Mutation_p.D30N	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	37	Cytoplasmic (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		ACAGTACTTAGACAATGATGA	0.408													A	174814645	A	A	174814645	3	1	160	1	0	0	0	0	1	0	0	0	10130	942	33	3	115	3	NAALADL2	3	174814645	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	36597739	174814645	23207785	21	11358											
PDGFRA	5156	broad.mit.edu	37	chr4	55131142	55131142	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaaccgtgtataagtcagggGaaacgattgtggtcacctgt	12	7	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr4:55131142G>A	uc003han.3	+	5	1016	c.685G>A	c.(685-687)GAA>AAA	p.E229K	PDGFRA_uc003haa.2_Intron|PDGFRA_uc003hal.2_3'UTR|PDGFRA_uc010igq.1_Missense_Mutation_p.E123K|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	229	Ig-like C2-type 3.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TAAGTCAGGGGAAACGATTGT	0.413			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			A	55131142	A	A	55131142	3	1	160	1	0	0	0	0	1	0	0	0	11661	1175	41	3	699	3	PDGFRA	4	55131142	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08		55131142	136023134	22	11359											
LRBA	987	broad.mit.edu	37	chr4	151357950	151357950	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gtgaaactttggaacttgatCatcttcccatgattcataac	6	9	3	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr4:151357950C>A	uc010ipj.2	-	46	7354	c.6880G>T	c.(6880-6882)GAT>TAT	p.D2294Y	LRBA_uc010ipi.2_5'UTR|LRBA_uc003ils.3_Missense_Mutation_p.D184Y|LRBA_uc003ilt.3_Missense_Mutation_p.D942Y|LRBA_uc003ilu.3_Missense_Mutation_p.D2283Y	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2294	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					GGAACTTGATCATCTTCCCAT	0.388													A	151357950	A	A	151357950	3	1	160	1	0	0	0	0	1	0	0	0	8931	826	29	5	1763	5	LRBA	4	151357950	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	96226808	151357950	39796326	23	11360											
FGG	2266	broad.mit.edu	37	chr4	155528109	155528109	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgtcagcttcaggtcccaCcttgaacatggcatagtctg	9	12	3	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr4:155528109C>T	uc003ioj.2	-	8	1018	c.877G>A	c.(877-879)GTG>ATG	p.V293M	FGG_uc003iog.2_Missense_Mutation_p.V293M|FGG_uc003ioh.2_Missense_Mutation_p.V301M|FGG_uc010ipx.2_Missense_Mutation_p.V121M|FGG_uc010ipy.2_Missense_Mutation_p.V4M|FGG_uc003ioi.2_Missense_Mutation_p.V4M|FGG_uc003iok.2_Missense_Mutation_p.V301M	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	293	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TCAGGTCCCACCTTGAACATG	0.493													T	155528109	T	T	155528109	3	4	160	1	0	0	0	0	1	0	0	0	5870	507	18	3	511	3	FGG	4	155528109	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	4170159	155528109	35626167	24	11361											
SPEF2	79925	broad.mit.edu	37	chr5	35659271	35659271	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaacaacatgaggaaagaCgacttaaagatttccaggat	8	6	0	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:35659271C>T	uc003jjo.2	+	8	1240	c.1129C>T	c.(1129-1131)CGA>TGA	p.R377*	SPEF2_uc003jjn.1_Nonsense_Mutation_p.R377*|SPEF2_uc003jjq.3_Nonsense_Mutation_p.R377*	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	377	Potential.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGAGGAAAGACGACTTAAAGA	0.408													T	35659271	T	T	35659271	4	4	160	1	0	0	0	0	0	1	0	0	15034	528	19	1	1159	1	SPEF2	5	35659271	Nonsense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08		35659271	145255989	25	11362											
C5orf39	389289	broad.mit.edu	37	chr5	43040065	43040065	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggcccacgatcttctgaactCacaataggtggaggctgggg	14	10	3	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:43040065C>T	uc003jnf.2	-	1	383	c.84G>A	c.(82-84)GTG>GTA	p.V28V	C5orf39_uc010ivj.1_RNA|LOC153684_uc003jng.2_5'Flank|LOC153684_uc003jni.2_5'Flank	NM_001014279	NP_001014301	Q3ZCQ2	AX2R_HUMAN	annexin II receptor	28							receptor activity				0						CTTCTGAACTCACAATAGGTG	0.557											OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	43040065	T	T	43040065	2	4	160	1	0	0	0	0	0	0	0	1	2297	813	29	3		3	C5orf39	5	43040065	Silent	SNP	C	TCGA-19-2631-01A-01D-1353-08	7380794	43040065	137875195	26	11363											
ITGA1	3672	broad.mit.edu	37	chr5	52145207	52145207	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctcctaaagttgttctaCgctgctgcgtatcattcaat	6	10	4	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:52145207C>T	uc003jou.2	+	2	122	c.70C>T	c.(70-72)CGC>TGC	p.R24C	ITGA1_uc003jov.2_RNA	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	24					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				AGTTGTTCTACGCTGCTGCGT	0.373													T	52145207	T	T	52145207	3	4	160	1	0	0	0	0	1	0	0	0	7872	536	19	1	76	1	ITGA1	5	52145207	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	9105142	52145207	128770053	27	11364											
ANKRD34B	340120	broad.mit.edu	37	chr5	79855139	79855139	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggccccttaggggccaatgCaggtttcctcacaggggaac	14	12	1	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:79855139C>T	uc010jam.2	-	4	1050	c.700G>A	c.(700-702)GCA>ACA	p.A234T	ANKRD34B_uc003kgw.2_Missense_Mutation_p.A234T|ANKRD34B_uc010jan.2_Missense_Mutation_p.A234T	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	234						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		GGGGCCAATGCAGGTTTCCTC	0.522													T	79855139	T	T	79855139	3	4	160	1	0	0	0	0	1	0	0	0	663	710	25	3	848	3	ANKRD34B	5	79855139	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	27709932	79855139	101060121	28	11365											
SLCO4C1	353189	broad.mit.edu	37	chr5	101585466	101585466	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacaattggcattacaagggGctatcaagtttcccaattct	7	9	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:101585466G>A	uc003knm.2	-	9	1783	c.1496C>T	c.(1495-1497)GCC>GTC	p.A499V		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	499	Kazal-like.|Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		ATTACAAGGGGCTATCAAGTT	0.373													A	101585466	A	A	101585466	3	1	160	1	0	0	0	0	1	0	0	0	14730	1203	42	3	698	3	SLCO4C1	5	101585466	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	21730327	101585466	79329794	29	11366											
TXNDC15	79770	broad.mit.edu	37	chr5	134223439	134223439	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcagcctgctcaccctctccAggtgggggctgtgtacctgg	14	14	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:134223439A>G	uc003lac.1	+	2	816	c.158A>G	c.(157-159)CAG>CGG	p.Q53R	TXNDC15_uc010jdy.1_Intron|TXNDC15_uc011cxv.1_RNA	NM_024715	NP_078991	Q96J42	TXD15_HUMAN	disulfide isomerase precursor	53	Extracellular (Potential).				cell redox homeostasis	integral to membrane				ovary(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CACCCTCTCCAGGTGGGGGCT	0.567													G	134223439	G	G	134223439	3	3	160	1	0	0	0	0	1	0	0	0	16791	188	7	4	164	4	TXNDC15	5	134223439	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08	32637973	134223439	46691821	30	11367											
CDC23	8697	broad.mit.edu	37	chr5	137548883	137548883	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgctcccgggtaaggcccGcaataagcagcagttgcttt	11	14	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:137548883G>A	uc003lcl.2	-	1	150	c.119C>T	c.(118-120)GCG>GTG	p.A40V	CDC23_uc003lcm.1_Missense_Mutation_p.A40V	NM_004661	NP_004652	Q9UJX2	CDC23_HUMAN	cell division cycle protein 23	40					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GGTAAGGCCCGCAATAAGCAG	0.572													A	137548883	A	A	137548883	3	1	160	1	0	0	0	0	1	0	0	0	3061	1087	38	1	1738	1	CDC23	5	137548883	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	3325444	137548883	43366377	31	11368											
FAM53C	51307	broad.mit.edu	37	chr5	137682463	137682463	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcatctctccaccatggttcAtggcctgtagccccccaccc	7	19	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:137682463A>G	uc003lcv.2	+	5	1464	c.994A>G	c.(994-996)ATG>GTG	p.M332V	FAM53C_uc003lcw.2_Missense_Mutation_p.M332V|FAM53C_uc011cyq.1_RNA|FAM53C_uc011cyr.1_3'UTR	NM_001135647	NP_001129119	Q9NYF3	FA53C_HUMAN	hypothetical protein LOC51307	332										ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACCATGGTTCATGGCCTGTAG	0.572													G	137682463	G	G	137682463	3	3	160	1	0	0	0	0	1	0	0	0	5581	217	8	4	1008	4	FAM53C	5	137682463	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08	133580	137682463	43232797	32	11369											
PCDHA1	56147	broad.mit.edu	37	chr5	140167728	140167728	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagccggcagcaggcggcgCgcgcatcccgttccgcgtgg	17	16	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:140167728C>T	uc003lhb.2	+	1	1853	c.1853C>T	c.(1852-1854)GCG>GTG	p.A618V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.A618V	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	618	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGGCGGCGCGCGCATCCCG	0.672													T	140167728	T	T	140167728	3	4	160	1	0	0	0	0	1	0	0	0	11519	768	27	1	1855	1	PCDHA1	5	140167728	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	2485265	140167728	40747532	33	11370											
PCDHB7	56129	broad.mit.edu	37	chr5	140553181	140553181	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcaggtgcccgaaaatagCcccgttggttccatggttgt	13	10	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:140553181C>T	uc003lit.2	+	1	939	c.765C>T	c.(763-765)AGC>AGT	p.S255S		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	255	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGAAAATAGCCCCGTTGGTT	0.507													T	140553181	T	T	140553181	2	4	160	1	0	0	0	0	0	0	0	1	11547	738	26	3		3	PCDHB7	5	140553181	Silent	SNP	C	TCGA-19-2631-01A-01D-1353-08	385453	140553181	40362079	34	11371											
SLC34A1	6569	broad.mit.edu	37	chr5	176815108	176815108	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	catcactcgacttgtggtggCctccttcaacatccatggtg	9	13	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:176815108C>A	uc003mgk.3	+	7	859	c.758C>A	c.(757-759)GCC>GAC	p.A253D		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	253	Extracellular (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTTGTGGTGGCCTCCTTCAAC	0.592													A	176815108	A	A	176815108	3	1	160	1	0	0	0	0	1	0	0	0	14567	739	26	5	780	5	SLC34A1	5	176815108	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	36261927	176815108	4100152	35	11372											
FLT4	2324	broad.mit.edu	37	chr5	180048821	180048821	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atgctcgtacttgtagctgtCggcttggcagctcaggagca	13	10	1	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr5:180048821C>T	uc003mma.3	-	13	1820	c.1741G>A	c.(1741-1743)GAC>AAC	p.D581N	FLT4_uc003mlz.3_Missense_Mutation_p.D581N|FLT4_uc003mmb.1_Missense_Mutation_p.D114N|FLT4_uc011dgy.1_Missense_Mutation_p.D581N	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	581	Ig-like C2-type 6.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TTGTAGCTGTCGGCTTGGCAG	0.617									Congenital_Hereditary_Lymphedema				T	180048821	T	T	180048821	3	4	160	1	0	0	0	0	1	0	0	0	5944	884	31	2	2430	2	FLT4	5	180048821	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	3233713	180048821	866439	36	11373											
NKAPL	222698	broad.mit.edu	37	chr6	28227888	28227888	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	agaataagaaaaccaaaaaaGaatccagtgactcaagctgt	7	7	1	4			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr6:28227888G>A	uc003nkt.2	+	1	791	c.739G>A	c.(739-741)GAA>AAA	p.E247K	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	247										upper_aerodigestive_tract(1)|ovary(1)	2						AACCAAAAAAGAATCCAGTGA	0.308													A	28227888	A	A	28227888	3	1	160	1	0	0	0	0	1	0	0	0	10440	943	33	3	741	3	NKAPL	6	28227888	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08		28227888	142887179	37	11374											
PKHD1	5314	broad.mit.edu	37	chr6	51768472	51768472	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attggagagtccctcggcacCagaaacctggatgatcacgt	11	11	1	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr6:51768472C>T	uc003pah.1	-	43	7195	c.6919G>A	c.(6919-6921)GGT>AGT	p.G2307S	PKHD1_uc010jzn.1_Missense_Mutation_p.G290S|PKHD1_uc003pai.2_Missense_Mutation_p.G2307S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2307	PbH1 3.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCCTCGGCACCAGAAACCTGG	0.418													T	51768472	T	T	51768472	3	4	160	1	0	0	0	0	1	0	0	0	11971	594	21	3	5444	3	PKHD1	6	51768472	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	23540584	51768472	119346595	38	11375											
BMP5	653	broad.mit.edu	37	chr6	55638880	55638880	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cattctggaggagtcctgatGagagctggatttattgcggt	14	6	1	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr6:55638880G>A	uc003pcq.2	-	4	1706	c.994C>T	c.(994-996)CAT>TAT	p.H332Y	BMP5_uc011dxf.1_Missense_Mutation_p.H332Y	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	332					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GAGTCCTGATGAGAGCTGGAT	0.468													A	55638880	A	A	55638880	3	1	160	1	0	0	0	0	1	0	0	0	1463	1290	45	3	386	3	BMP5	6	55638880	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	3870408	55638880	115476187	39	11376											
BEND6	221336	broad.mit.edu	37	chr6	56883316	56883316	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	accaagaagccaaatttaagCaaaaatcttaactctcagga	5	9	2	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr6:56883316C>G	uc010kab.2	+	6	1396	c.810C>G	c.(808-810)AGC>AGG	p.S270R	BEND6_uc003pdi.3_Missense_Mutation_p.S172R	NM_152731	NP_689944	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	270	BEN.										0						CAAATTTAAGCAAAAATCTTA	0.313													G	56883316	G	G	56883316	3	3	160	1	0	0	0	0	1	0	0	0	1402	709	25	5	828	5	BEND6	6	56883316	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	1244436	56883316	114231751	40	11377											
KHDRBS2	202559	broad.mit.edu	37	chr6	62611257	62611257	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attcacgtagttgttcctgaCgaatttcatcattgtagtcc	7	9	3	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr6:62611257C>T	uc003peg.2	-	5	750	c.503G>A	c.(502-504)CGT>CAT	p.R168H		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TTGTTCCTGACGAATTTCATC	0.403													T	62611257	T	T	62611257	3	4	160	1	0	0	0	0	1	0	0	0	8147	536	19	1	566	1	KHDRBS2	6	62611257	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	5727941	62611257	108503810	41	11378											
SNAP91	9892	broad.mit.edu	37	chr6	84303343	84303343	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaggagcagttgcgggaactGgaggggctgtgctagctgta	18	6	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr6:84303343G>C	uc011dze.1	-	17	1867	c.1550C>G	c.(1549-1551)CCA>CGA	p.P517R	SNAP91_uc011dzd.1_Missense_Mutation_p.P20R|SNAP91_uc003pkb.2_Missense_Mutation_p.P480R|SNAP91_uc003pkc.2_Missense_Mutation_p.P515R|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Missense_Mutation_p.P515R	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	517	Ala-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TGCGGGAACTGGAGGGGCTGT	0.313													C	84303343	C	C	84303343	3	2	160	1	0	0	0	0	1	0	0	0	14833	1348	47	5	1221	5	SNAP91	6	84303343	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	21692086	84303343	86811724	42	11379											
MAP3K7	6885	broad.mit.edu	37	chr6	91266234	91266234	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttaccttcaaaaacttcagGtgccatccaagcagcactcc	5	14	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr6:91266234G>A	uc003pnz.1	-	6	754	c.592C>T	c.(592-594)CCT>TCT	p.P198S	MAP3K7_uc003poa.1_Missense_Mutation_p.P198S|MAP3K7_uc003pob.1_Missense_Mutation_p.P198S|MAP3K7_uc003poc.1_Missense_Mutation_p.P198S	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	198	Protein kinase.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		AAAACTTCAGGTGCCATCCAA	0.403													A	91266234	A	A	91266234	3	1	160	1	0	0	0	0	1	0	0	0	9255	1261	44	3	1276	3	MAP3K7	6	91266234	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	6962891	91266234	79848833	43	11380											
SEPT7	989	broad.mit.edu	37	chr7	35942771	35942771	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acgtcgtcagttcgaggatgAgaaagcaaactgggaagctc	13	8	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr7:35942771A>G	uc010kxc.2	+	12	1413	c.1220A>G	c.(1219-1221)GAG>GGG	p.E407G	SEPT7_uc011kat.1_Missense_Mutation_p.E406G|SEPT7_uc011kau.1_Missense_Mutation_p.E371G|SEPT7_uc011kav.1_Missense_Mutation_p.E354G|SEPT7_uc003tey.2_Missense_Mutation_p.E255G	NM_001788	NP_001779	Q16181	SEPT7_HUMAN	cell division cycle 10 isoform 1	407	Potential.				cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity				0						TTCGAGGATGAGAAAGCAAAC	0.383													G	35942771	G	G	35942771	3	3	160	1	0	0	0	0	1	0	0	0	14069	304	11	4	1264	4	SEPT7	7	35942771	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08		35942771	123195892	44	11381											
C7orf64	84060	broad.mit.edu	37	chr7	92163996	92163997	+	Frame_Shift_Del	DEL	TT	-	-													cattataaccacaatgactcTttgcggaaaacacagataaa							TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr7:92163996_92163997delTT	uc003ulz.2	+	4	770_771	c.729_730delTT	c.(727-732)TCTTTGfs	p.S243fs	C7orf64_uc003uma.2_Frame_Shift_Del_p.S243fs	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	243_244							nucleotide binding			ovary(2)	2						ACAATGACTCTTTGCGGAAAAC	0.45													-	92163997	-	-	92163996	7	5	160	1	0	1	0	1	0	0	0	0	2410	1596	56	0	743	0	C7orf64	7	92163996	Frame_Shift_Del	DEL	TT	TCGA-19-2631-01A-01D-1353-08	56221225	92163996	66974667	45	11382											
SRRT	51593	broad.mit.edu	37	chr7	100485931	100485931	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gccctccatacccccatgccCcgtatggtgctggtcgaggg	12	16	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr7:100485931C>G	uc003uwy.2	+	20	2750	c.2482C>G	c.(2482-2484)CCG>GCG	p.P828A	SRRT_uc010lhl.1_Missense_Mutation_p.P827A|SRRT_uc003uxa.2_Missense_Mutation_p.P823A|SRRT_uc003uwz.2_Missense_Mutation_p.P824A|uc010lhm.1_5'Flank	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	828	Pro-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						CCCCCATGCCCCGTATGGTGC	0.577													G	100485931	G	G	100485931	3	3	160	1	0	0	0	0	1	0	0	0	15171	623	22	5	2552	5	SRRT	7	100485931	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	8321935	100485931	58652732	46	11383											
LAMB4	22798	broad.mit.edu	37	chr7	107708521	107708521	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacctgtcacagcagcgccCgaccacaagaggtttacact	9	15	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr7:107708521C>T	uc010ljo.1	-	19	2470	c.2386G>A	c.(2386-2388)GGG>AGG	p.G796R	LAMB4_uc003vey.2_Missense_Mutation_p.G796R	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	796	Laminin EGF-like 6.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						CAGCAGCGCCCGACCACAAGA	0.567													T	107708521	T	T	107708521	3	4	160	1	0	0	0	0	1	0	0	0	8613	652	23	2	2963	2	LAMB4	7	107708521	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	7222590	107708521	51430142	47	11384											
GPR85	54329	broad.mit.edu	37	chr7	112724397	112724397	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagcctctttgtatagaagCggtgatgggcgatagctaaa	12	7	2	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr7:112724397C>T	uc010ljv.2	-	2	897	c.380G>A	c.(379-381)CGC>CAC	p.R127H	GPR85_uc003vgp.1_Missense_Mutation_p.R127H|GPR85_uc003vgq.2_Missense_Mutation_p.R127H|GPR85_uc010ljw.1_Missense_Mutation_p.R127H	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	127	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						TGTATAGAAGCGGTGATGGGC	0.493													T	112724397	T	T	112724397	3	4	160	1	0	0	0	0	1	0	0	0	6715	768	27	1	736	1	GPR85	7	112724397	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	5015876	112724397	46414266	48	11385											
GRM8	2918	broad.mit.edu	37	chr7	126173579	126173579	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggagcacgtaactaagttcGcgtcctgaagccctcacgat	10	12	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr7:126173579G>A	uc003vlr.2	-	8	2168	c.1857C>T	c.(1855-1857)CGC>CGT	p.R619R	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.R619R|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	619	Cytoplasmic (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AACTAAGTTCGCGTCCTGAAG	0.458										HNSCC(24;0.065)			A	126173579	A	A	126173579	2	1	160	1	0	0	0	0	0	0	0	1	6803	1074	38	1		1	GRM8	7	126173579	Silent	SNP	G	TCGA-19-2631-01A-01D-1353-08	13449182	126173579	32965084	49	11386											
CALD1	800	broad.mit.edu	37	chr7	134618735	134618735	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgcaagagacaaagataaaAggggaaaaggtagaacagaa	12	3	0	4			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr7:134618735A>G	uc003vrz.2	+	5	1674	c.1215A>G	c.(1213-1215)AAA>AAG	p.K405K	CALD1_uc003vry.2_Intron|CALD1_uc003vsa.2_Intron|CALD1_uc003vsb.2_Intron|CALD1_uc010lmm.2_Intron|CALD1_uc011kpt.1_Intron|CALD1_uc003vsc.2_Intron|CALD1_uc003vsd.2_Intron|CALD1_uc011kpu.1_Intron|CALD1_uc011kpv.1_Intron|CALD1_uc003vse.2_Silent_p.K269K	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	405					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						CAAAGATAAAAGGGGAAAAGG	0.418													G	134618735	G	G	134618735	2	3	160	1	0	0	0	0	0	0	0	1	2581	69	3	4		4	CALD1	7	134618735	Silent	SNP	A	TCGA-19-2631-01A-01D-1353-08	8445156	134618735	24519928	50	11387											
ADAM2	2515	broad.mit.edu	37	chr8	39626970	39626970	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctttgcattaccacacactgCttgctgtttgaaaaaaggat	7	9	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr8:39626970C>A	uc003xnj.2	-	12	1228	c.1153G>T	c.(1153-1155)GCA>TCA	p.A385S	ADAM2_uc003xnk.2_Missense_Mutation_p.A366S|ADAM2_uc011lck.1_Missense_Mutation_p.A385S|ADAM2_uc003xnl.2_Missense_Mutation_p.A259S	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	385	Extracellular (Potential).|Disintegrin.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CCACACACTGCTTGCTGTTTG	0.448													A	39626970	A	A	39626970	3	1	160	1	0	0	0	0	1	0	0	0	241	797	28	5	1090	5	ADAM2	8	39626970	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08		39626970	106737052	51	11388											
TMEM55A	55529	broad.mit.edu	37	chr8	92007945	92007945	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gataactgactcttatggctCcccaataacaagctcggata	7	11	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr8:92007945C>T	uc003yes.2	-	7	960	c.734G>A	c.(733-735)GGA>GAA	p.G245E		NM_018710	NP_061180	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A	245	Helical; (Potential).					integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0			BRCA - Breast invasive adenocarcinoma(11;0.033)			TCTTATGGCTCCCCAATAACA	0.438													T	92007945	T	T	92007945	3	4	160	1	0	0	0	0	1	0	0	0	16178	855	30	3	43	3	TMEM55A	8	92007945	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	52380975	92007945	54356077	52	11389											
TRPS1	7227	broad.mit.edu	37	chr8	116430676	116430676	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaaacaccggagcctctaCgcctctgaaacaggggaaaa	9	11	2	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr8:116430676C>T	uc003ynz.2	-	5	3125	c.2666G>A	c.(2665-2667)CGT>CAT	p.R889H	TRPS1_uc011lhy.1_Missense_Mutation_p.R893H|TRPS1_uc003yny.2_Missense_Mutation_p.R902H|TRPS1_uc010mcy.2_Missense_Mutation_p.R889H	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	889					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R889C(1)		ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GGAGCCTCTACGCCTCTGAAA	0.478									Langer-Giedion_syndrome				T	116430676	T	T	116430676	3	4	160	1	0	0	0	0	1	0	0	0	16590	536	19	1	1187	1	TRPS1	8	116430676	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	24422731	116430676	29933346	53	11390											
RANBP6	26953	broad.mit.edu	37	chr9	6012502	6012502	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attggaattatttggaccaaTtacaactgggtggttacttt	9	5	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr9:6012502T>G	uc003zjr.2	-	1	3117	c.3106A>C	c.(3106-3108)ATT>CTT	p.I1036L	RANBP6_uc011lmf.1_Missense_Mutation_p.I684L|RANBP6_uc003zjs.2_Missense_Mutation_p.I624L	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	1036					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TTTGGACCAATTACAACTGGG	0.368													G	6012502	G	G	6012502	3	3	160	1	0	0	0	0	1	0	0	0	13031	1493	52	5	215	5	RANBP6	9	6012502	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08		6012502	135200929	54	11391											
C9orf41	138199	broad.mit.edu	37	chr9	77631261	77631261	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccctttctgctttcccagtTtcactccagtctctcacaaa	3	16	4	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr9:77631261T>G	uc004ajq.2	-	3	666	c.513A>C	c.(511-513)GAA>GAC	p.E171D	C9orf41_uc011lsi.1_RNA	NM_152420	NP_689633	Q8N4J0	CI041_HUMAN	hypothetical protein LOC138199	171										ovary(1)|skin(1)	2						CTTTCCCAGTTTCACTCCAGT	0.353													G	77631261	G	G	77631261	3	3	160	1	0	0	0	0	1	0	0	0	2482	1838	64	5	740	5	C9orf41	9	77631261	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08	71618759	77631261	63582170	55	11392											
TLE1	7088	broad.mit.edu	37	chr9	84200544	84200544	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccactgccagccactccccGgtggggcagtaccccaggga	12	18	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr9:84200544G>A	uc004aly.2	-	18	2445	c.2004C>T	c.(2002-2004)ACC>ACT	p.T668T	TLE1_uc004alz.2_Silent_p.T678T|TLE1_uc011lsr.1_Silent_p.T653T	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	668					negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						GCCACTCCCCGGTGGGGCAGT	0.557													A	84200544	A	A	84200544	2	1	160	1	0	0	0	0	0	0	0	1	15935	1103	39	2		2	TLE1	9	84200544	Silent	SNP	G	TCGA-19-2631-01A-01D-1353-08	6569283	84200544	57012887	56	11393											
FAM22F	54754	broad.mit.edu	37	chr9	97081002	97081002	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggagactgaagagctccctgGggtcctctccctcctgggct	13	14	1	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr9:97081002G>T	uc004aup.1	-	7	2037	c.2016C>A	c.(2014-2016)CCC>CCA	p.P672P		NM_017561	NP_060031	A1L443	FA22F_HUMAN	hypothetical protein LOC54754	672											0		Acute lymphoblastic leukemia(62;0.136)				GAGCTCCCTGGGGTCCTCTCC	0.607													T	97081002	T	T	97081002	2	4	160	1	0	0	0	0	0	0	0	1	5545	1219	43	5		5	FAM22F	9	97081002	Silent	SNP	G	TCGA-19-2631-01A-01D-1353-08	12880458	97081002	44132429	57	11394											
FAM22G	441457	broad.mit.edu	37	chr9	99694201	99694201	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcaggacaggatggccgcGgcccaagtggggctggggct	20	10	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr9:99694201G>A	uc004awq.1	+	2	929	c.214G>A	c.(214-216)GGC>AGC	p.G72S		NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	72										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				GGATGGCCGCGGCCCAAGTGG	0.642													A	99694201	A	A	99694201	3	1	160	1	0	0	0	0	1	0	0	0	5546	1116	39	2	220	2	FAM22G	9	99694201	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	2613199	99694201	41519230	58	11395											
ANKRD26	22852	broad.mit.edu	37	chr10	27324683	27324683	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcatgactatgagaattcTaagtaaaacaaaggaaactt	6	6	2	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr10:27324683T>C	uc001ith.2	-	24	2867	c.2695_splice	c.e24-1	p.N899_splice	ANKRD26_uc001itg.2_Splice_Site_p.N586_splice|ANKRD26_uc009xku.1_Splice_Site_p.N900_splice	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26							centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						ATGAGAATTCTAAGTAAAACA	0.313													C	27324683	C	C	27324683	5	2	160	1	0	0	0	0	0	0	1	0	654	1536	53	4	2480	4	ANKRD26	10	27324683	Splice_Site	SNP	T	TCGA-19-2631-01A-01D-1353-08		27324683	108210064	59	11396											
TLL2	7093	broad.mit.edu	37	chr10	98173027	98173027	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggccaatggttggcctgaCgccattgtcatcttgacggg	13	11	2	2	rs61743696		TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr10:98173027C>T	uc001kml.1	-	8	1196	c.970G>A	c.(970-972)GTC>ATC	p.V324I	TLL2_uc009xvf.1_Missense_Mutation_p.V272I	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	324	Metalloprotease (By similarity).				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GTTGGCCTGACGCCATTGTCA	0.522													T	98173027	T	T	98173027	3	4	160	1	0	0	0	0	1	0	0	0	15943	536	19	1	2133	1	TLL2	10	98173027	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	70848344	98173027	37361720	60	11397											
LOC729020	729020	broad.mit.edu	37	chr10	105005929	105005929	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtggtagaaagccttcgaaAgcagctaggccaggaccctt	12	10	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr10:105005929A>G	uc009xxi.2	+	1	286	c.176A>G	c.(175-177)AAG>AGG	p.K59R	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	59					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						AGCCTTCGAAAGCAGCTAGGC	0.498													G	105005929	G	G	105005929	3	3	160	1	0	0	0	0	1	0	0	0	8888	72	3	4	178	4	LOC729020	10	105005929	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08	6832902	105005929	30528818	61	11398											
INS	3630	broad.mit.edu	37	chr11	2181187	2181187	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tccagggccaagggctgcagGctgcctgcaccagggccccc	14	17	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr11:2181187G>C	uc001lvn.1	-	3	283	c.228C>G	c.(226-228)AGC>AGG	p.S76R	INS-IGF2_uc001lvi.2_Intron|INS-IGF2_uc001lvm.2_Intron|INS_uc001lvo.1_Missense_Mutation_p.S76R|INS_uc009ydg.1_Missense_Mutation_p.S64R	NM_000207	NP_000198	P01308	INS_HUMAN	proinsulin precursor	76					activation of protein kinase B activity|acute-phase response|alpha-beta T cell activation|endocrine pancreas development|energy reserve metabolic process|fatty acid homeostasis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|glucose metabolic process|glucose transport|insulin receptor signaling pathway|MAPKKK cascade|negative regulation of acute inflammatory response|negative regulation of apoptosis|negative regulation of fatty acid metabolic process|negative regulation of feeding behavior|negative regulation of gluconeogenesis|negative regulation of glycogen catabolic process|negative regulation of lipid catabolic process|negative regulation of NAD(P)H oxidase activity|negative regulation of protein catabolic process|negative regulation of protein secretion|negative regulation of proteolysis|negative regulation of respiratory burst involved in inflammatory response|negative regulation of vasodilation|positive regulation of cell differentiation|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine secretion|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin receptor signaling pathway|positive regulation of lipid biosynthetic process|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of respiratory burst|positive regulation of vasodilation|regulation of cellular amino acid metabolic process|regulation of insulin secretion|regulation of transmembrane transporter activity|wound healing	endoplasmic reticulum lumen|endosome lumen|extracellular space	hormone activity|insulin receptor binding|insulin-like growth factor receptor binding				0		Lung NSC(207;8.94e-06)|all_epithelial(84;3.17e-05)|all_lung(207;3.67e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.14)		AGGGCTGCAGGCTGCCTGCAC	0.662													C	2181187	C	C	2181187	3	2	160	1	0	0	0	0	1	0	0	0	7762	1194	42	5	108	5	INS	11	2181187	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08		2181187	132825329	62	11399											
CCKBR	887	broad.mit.edu	37	chr11	6291993	6291993	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgacggcgacagtgacagCgacagccaaagcagggtccg	14	11	0	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr11:6291993C>T	uc001mcp.2	+	4	964	c.771C>T	c.(769-771)AGC>AGT	p.S257S	CCKBR_uc001mcq.2_Silent_p.S185S|CCKBR_uc001mcr.2_Silent_p.S257S|CCKBR_uc001mcs.2_Silent_p.S257S|CCKBR_uc001mct.1_5'Flank	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	257	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	ACAGTGACAGCGACAGCCAAA	0.622													T	6291993	T	T	6291993	2	4	160	1	0	0	0	0	0	0	0	1	2881	767	27	1		1	CCKBR	11	6291993	Silent	SNP	C	TCGA-19-2631-01A-01D-1353-08	4110806	6291993	128714523	63	11400											
RAG1	5896	broad.mit.edu	37	chr11	36595309	36595309	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagagagctacttcctggcCggacctcattgccaaggttt	10	11	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr11:36595309C>T	uc001mwu.3	+	2	579	c.455C>T	c.(454-456)CCG>CTG	p.P152L	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	152	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				ACTTCCTGGCCGGACCTCATT	0.507									Familial_Hemophagocytic_Lymphohistiocytosis				T	36595309	T	T	36595309	3	4	160	1	0	0	0	0	1	0	0	0	13003	652	23	2	457	2	RAG1	11	36595309	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	30303316	36595309	98411207	64	11401											
ACCSL	390110	broad.mit.edu	37	chr11	44077630	44077630	+	Frame_Shift_Del	DEL	A	-	-													cccatgtgatctggggtaccAgtaaggtgagccattgcttt							TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr11:44077630delA	uc001mxw.1	+	10	1236	c.1180delA	c.(1180-1182)AGTfs	p.S394fs	ACCSL_uc009ykr.2_Frame_Shift_Del_p.S213fs	NM_001031854	NP_001027025	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase	394							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(5)	5						CTGGGGTACCAGTAAGGTGAG	0.443													-	44077630	-	-	44077630	7	5	160	1	0	1	0	1	0	0	0	0	134	188	7	0	1218	0	ACCSL	11	44077630	Frame_Shift_Del	DEL	A	TCGA-19-2631-01A-01D-1353-08	7482321	44077630	90928886	65	11402											
CREB3L1	90993	broad.mit.edu	37	chr11	46341859	46341859	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgatgacggggcaggcttaTgggaagatggccgcagcacc	16	10	0	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr11:46341859T>C	uc001ncf.2	+	11	1738	c.1303T>C	c.(1303-1305)TGG>CGG	p.W435R	CREB3L1_uc001ncg.2_Missense_Mutation_p.W69R	NM_052854	NP_443086	Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like	435	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	soft_tissue(6)|ovary(2)	8				GBM - Glioblastoma multiforme(35;0.0285)		GGCAGGCTTATGGGAAGATGG	0.652			T	FUS	myxofibrosarcoma								C	46341859	C	C	46341859	3	2	160	1	0	0	0	0	1	0	0	0	3856	1464	51	4	1345	4	CREB3L1	11	46341859	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08	2264229	46341859	88664657	66	11403											
OR5A1	219982	broad.mit.edu	37	chr11	59211096	59211096	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acgcatggtggttggggcatAtgttggtggcttcctgagct	16	7	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr11:59211096A>T	uc001nnx.1	+	1	455	c.455A>T	c.(454-456)TAT>TTT	p.Y152F		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						GTTGGGGCATATGTTGGTGGC	0.547													T	59211096	T	T	59211096	3	4	160	1	0	0	0	0	1	0	0	0	11139	449	16	5	457	5	OR5A1	11	59211096	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08	12869237	59211096	75795420	67	11404											
CABP4	57010	broad.mit.edu	37	chr11	67225877	67225877	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatggacgaattacggtggcGgagctgcgggaggcggtacc	19	8	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr11:67225877G>A	uc001olo.2	+	5	764	c.687G>A	c.(685-687)GCG>GCA	p.A229A	CABP4_uc001oln.2_Silent_p.A124A	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	229	EF-hand 3.|2 (Potential).				visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			TTACGGTGGCGGAGCTGCGGG	0.647													A	67225877	A	A	67225877	2	1	160	1	0	0	0	0	0	0	0	1	2533	1103	39	2		2	CABP4	11	67225877	Silent	SNP	G	TCGA-19-2631-01A-01D-1353-08	8014781	67225877	67780639	68	11405											
APOBEC1	339	broad.mit.edu	37	chr12	7803627	7803627	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaagtgacttactagaattaTgcagtgcagctccagtgcgt	10	8	0	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr12:7803627T>C	uc001qtb.2	-	4	587	c.553A>G	c.(553-555)ATA>GTA	p.I185V	APOBEC1_uc001qtc.2_Missense_Mutation_p.I140V|APOBEC1_uc010sgf.1_Missense_Mutation_p.I185V	NM_001644	NP_001635	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme	185	Leu-rich.				cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding				0						ACTAGAATTATGCAGTGCAGC	0.433													C	7803627	C	C	7803627	3	2	160	1	0	0	0	0	1	0	0	0	787	1464	51	4	165	4	APOBEC1	12	7803627	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08		7803627	126048268	69	11406											
PRB1	5542	broad.mit.edu	37	chr12	11506566	11506566	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgggggtggtccttgtggCtttcctggaggagatcaggg	19	6	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr12:11506566C>T	uc001qzw.1	-	4	508	c.471G>A	c.(469-471)AAG>AAA	p.K157K	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	218	9.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GTCCTTGTGGCTTTCCTGGAG	0.597													T	11506566	T	T	11506566	2	4	160	1	0	0	0	0	0	0	0	1	12442	796	28	3		3	PRB1	12	11506566	Silent	SNP	C	TCGA-19-2631-01A-01D-1353-08	3702939	11506566	122345329	70	11407											
KRT75	9119	broad.mit.edu	37	chr12	52828035	52828035	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggtgatggccgaggtggtGctgaagcccctgcggctgcc	19	11	0	2	rs140932366		TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr12:52828035G>A	uc001saj.2	-	1	76	c.54C>T	c.(52-54)AGC>AGT	p.S18S		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	18	Head.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		CCGAGGTGGTGCTGAAGCCCC	0.672													A	52828035	A	A	52828035	2	1	160	1	0	0	0	0	0	0	0	1	8488	1310	46	3		3	KRT75	12	52828035	Silent	SNP	G	TCGA-19-2631-01A-01D-1353-08	41321469	52828035	81023860	71	11408											
OR6C68	403284	broad.mit.edu	37	chr12	55886262	55886262	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtttctatttatcacctacaTgttgagtgtaacagggaaac	8	7	2	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr12:55886262T>A	uc010spo.1	+	1	116	c.116T>A	c.(115-117)ATG>AAG	p.M39K		NM_001005519	NP_001005519	A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATCACCTACATGTTGAGTGTA	0.398													A	55886262	A	A	55886262	3	1	160	1	0	0	0	0	1	0	0	0	11196	1464	51	5	118	5	OR6C68	12	55886262	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08	3058227	55886262	77965633	72	11409											
FAM19A2	338811	broad.mit.edu	37	chr12	62148677	62148677	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacacatgatggagcagctcGcgtggtgcctgccacctgcc	12	15	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr12:62148677G>A	uc001sqw.2	-	3	1748	c.235C>T	c.(235-237)CGA>TGA	p.R79*	FAM19A2_uc001sqv.2_RNA|FAM19A2_uc001sqx.2_Nonsense_Mutation_p.R79*|FAM19A2_uc001sqy.2_RNA	NM_178539	NP_848634	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine	79						cytoplasm				ovary(1)	1			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		GGAGCAGCTCGCGTGGTGCCT	0.502													A	62148677	A	A	62148677	4	1	160	1	0	0	0	0	0	1	0	0	5532	1095	38	1	172	1	FAM19A2	12	62148677	Nonsense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	6262415	62148677	71703218	73	11410											
GRIP1	23426	broad.mit.edu	37	chr12	66800092	66800092	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttcatctttgcggattttgAgcttcaccaggtcttcacat	7	11	5	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr12:66800092A>G	uc001stk.2	-	15	2040	c.1799T>C	c.(1798-1800)CTC>CCC	p.L600P	GRIP1_uc010sta.1_Missense_Mutation_p.L544P|GRIP1_uc001stj.2_Missense_Mutation_p.L382P|GRIP1_uc001stl.1_Missense_Mutation_p.L492P|GRIP1_uc001stm.2_Missense_Mutation_p.L600P	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	652	PDZ 5.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		GCGGATTTTGAGCTTCACCAG	0.413													G	66800092	G	G	66800092	3	3	160	1	0	0	0	0	1	0	0	0	6787	304	11	4	1471	4	GRIP1	12	66800092	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08	4651415	66800092	67051803	74	11411											
MED13L	23389	broad.mit.edu	37	chr12	116446291	116446291	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tggaggcctgaactcagcatCatcactgggtgggagacgat	14	9	3	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr12:116446291C>G	uc001tvw.2	-	10	1982	c.1927G>C	c.(1927-1929)GAT>CAT	p.D643H		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	643					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		AACTCAGCATCATCACTGGGT	0.517													G	116446291	G	G	116446291	3	3	160	1	0	0	0	0	1	0	0	0	9431	826	29	5	4793	5	MED13L	12	116446291	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	49646199	116446291	17405604	75	11412											
MPHOSPH9	10198	broad.mit.edu	37	chr12	123687854	123687854	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcctctcaggtaactgcttGttttccctttgttttttata	5	9	1	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr12:123687854G>A	uc001uel.2	-	5	914	c.807C>T	c.(805-807)AAC>AAT	p.N269N	MPHOSPH9_uc010tal.1_5'UTR|MPHOSPH9_uc010tam.1_Intron|MPHOSPH9_uc001uem.2_5'UTR	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	269					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		GTAACTGCTTGTTTTCCCTTT	0.373													A	123687854	A	A	123687854	2	1	160	1	0	0	0	0	0	0	0	1	9728	1368	48	3		3	MPHOSPH9	12	123687854	Silent	SNP	G	TCGA-19-2631-01A-01D-1353-08	7241563	123687854	10164041	76	11413											
TGM1	7051	broad.mit.edu	37	chr14	24730965	24730965	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgggacaggaggaggagcatAtggaaaggctgcccgcggcg	19	9	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr14:24730965A>G	uc001wod.2	-	3	568	c.444T>C	c.(442-444)CAT>CAC	p.H148H	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	148					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	GGAGGAGCATATGGAAAGGCT	0.592													G	24730965	G	G	24730965	2	3	160	1	0	0	0	0	0	0	0	1	15826	446	16	4		4	TGM1	14	24730965	Silent	SNP	A	TCGA-19-2631-01A-01D-1353-08		24730965	82618575	77	11414											
SRP54	6729	broad.mit.edu	37	chr14	35465958	35465958	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaaataacatcagcattaCgctcgttgagcaatgccacc	7	11	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr14:35465958C>T	uc001wso.2	+	2	394	c.43C>T	c.(43-45)CGC>TGC	p.R15C	SRP54_uc010tpp.1_Translation_Start_Site|SRP54_uc010tpq.1_Intron	NM_003136	NP_003127	P61011	SRP54_HUMAN	signal recognition particle 54kDa isoform 1	15	G-domain.				GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)		ATCAGCATTACGCTCGTTGAG	0.343													T	35465958	T	T	35465958	3	4	160	1	0	0	0	0	1	0	0	0	15154	536	19	1	45	1	SRP54	14	35465958	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	10734993	35465958	71883582	78	11415											
C14orf37	145407	broad.mit.edu	37	chr14	58471770	58471770	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gttgttggttccatacctttCttttatgccttttgaagcca	7	9	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr14:58471770C>G	uc001xdc.2	-	7	2363	c.2252G>C	c.(2251-2253)AGA>ACA	p.R751T	C14orf37_uc010tro.1_Missense_Mutation_p.R789T|C14orf37_uc001xdd.2_Missense_Mutation_p.R751T	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	751	Cytoplasmic (Potential).					integral to membrane	binding				0						CCATACCTTTCTTTTATGCCT	0.413													G	58471770	G	G	58471770	3	3	160	1	0	0	0	0	1	0	0	0	1771	913	32	5	80	5	C14orf37	14	58471770	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	23005812	58471770	48877770	79	11416											
GABRB3	2562	broad.mit.edu	37	chr15	26825568	26825568	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacagccttgtccccgcctcGccagtaaaactcaatgtcat	6	15	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr15:26825568G>A	uc001zaz.2	-	6	722	c.580C>T	c.(580-582)CGA>TGA	p.R194*	GABRB3_uc010uae.1_Nonsense_Mutation_p.R109*|GABRB3_uc001zba.2_Nonsense_Mutation_p.R194*|GABRB3_uc001zbb.2_Nonsense_Mutation_p.R250*	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	194	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCCCCGCCTCGCCAGTAAAAC	0.517													A	26825568	A	A	26825568	4	1	160	1	0	0	0	0	0	1	0	0	6168	1095	38	1	857	1	GABRB3	15	26825568	Nonsense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08		26825568	75705824	80	11417											
PCSK6	5046	broad.mit.edu	37	chr15	101924538	101924538	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgccgcacctttatgacccGcgccgttcactttccagtcg	8	17	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr15:101924538G>A	uc002bwy.2	-	11	1717	c.1403C>T	c.(1402-1404)GCG>GTG	p.A468V	PCSK6_uc010bpd.2_Intron|PCSK6_uc010bpe.2_Missense_Mutation_p.A468V|PCSK6_uc002bxa.2_Missense_Mutation_p.A468V|PCSK6_uc002bxb.2_Missense_Mutation_p.A468V|PCSK6_uc002bxc.1_Missense_Mutation_p.A468V|PCSK6_uc002bxd.1_Missense_Mutation_p.A468V|PCSK6_uc002bxe.2_Missense_Mutation_p.A468V|PCSK6_uc002bxg.1_Missense_Mutation_p.A468V|PCSK6_uc002bxf.1_5'Flank	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	468					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTTATGACCCGCGCCGTTCAC	0.567													A	101924538	A	A	101924538	3	1	160	1	0	0	0	0	1	0	0	0	11604	1087	38	1	2037	1	PCSK6	15	101924538	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	75098970	101924538	606854	81	11418											
GLYR1	84656	broad.mit.edu	37	chr16	4863830	4863830	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgcagcacaccactggggcCcagcaccagctgtggggaca	13	14	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr16:4863830C>T	uc002cxx.3	-	12	1064	c.1027G>A	c.(1027-1029)GGC>AGC	p.G343S	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Missense_Mutation_p.G257S|GLYR1_uc002cya.2_Missense_Mutation_p.G337S|GLYR1_uc010uxv.1_Missense_Mutation_p.G262S	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	343					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						CCACTGGGGCCCAGCACCAGC	0.612													T	4863830	T	T	4863830	3	4	160	1	0	0	0	0	1	0	0	0	6483	623	22	3	654	3	GLYR1	16	4863830	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08		4863830	85490923	82	11419											
ATF7IP2	80063	broad.mit.edu	37	chr16	10524533	10524533	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaagccaaaaagacaatgcCcctaagttgccggaagcaag	9	10	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr16:10524533C>T	uc002czu.2	+	3	283	c.56C>T	c.(55-57)CCC>CTC	p.P19L	ATF7IP2_uc002czv.2_Missense_Mutation_p.P19L|ATF7IP2_uc010uyo.1_RNA|ATF7IP2_uc010uyp.1_Intron|ATF7IP2_uc002czw.2_Missense_Mutation_p.P19L|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AAGACAATGCCCCTAAGTTGC	0.383													T	10524533	T	T	10524533	3	4	160	1	0	0	0	0	1	0	0	0	1088	623	22	3	58	3	ATF7IP2	16	10524533	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	5660703	10524533	79830220	83	11420											
UMOD	7369	broad.mit.edu	37	chr16	20359594	20359594	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagtgccatctgccattattCgatttgcagtcctcgtctat	7	12	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr16:20359594C>T	uc002dgz.2	-	4	1053	c.924G>A	c.(922-924)TCG>TCA	p.S308S	UMOD_uc002dha.2_Silent_p.S308S|UMOD_uc002dhb.2_Silent_p.S341S	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	308					cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						TGCCATTATTCGATTTGCAGT	0.552													T	20359594	T	T	20359594	2	4	160	1	0	0	0	0	0	0	0	1	16976	871	31	2		2	UMOD	16	20359594	Silent	SNP	C	TCGA-19-2631-01A-01D-1353-08	9835061	20359594	69995159	84	11421											
ITGAX	3687	broad.mit.edu	37	chr16	31373991	31373991	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctggtcctgggggcccccCgctaccagcacaccgggaag	14	17	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr16:31373991C>T	uc002ebu.1	+	12	1343	c.1276C>T	c.(1276-1278)CGC>TGC	p.R426C	ITGAX_uc002ebt.2_Missense_Mutation_p.R426C|ITGAX_uc010vfk.1_Missense_Mutation_p.R76C	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	426	FG-GAP 4.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGGGGCCCCCCGCTACCAGCA	0.657													T	31373991	T	T	31373991	3	4	160	1	0	0	0	0	1	0	0	0	7889	652	23	2	1322	2	ITGAX	16	31373991	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	11014397	31373991	58980762	85	11422											
MYO15A	51168	broad.mit.edu	37	chr17	18055238	18055238	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcctgaaagggcagatgacCcacctggcagctgcacctgg	12	13	0	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr17:18055238C>T	uc010vxh.1	+	40	8204	c.7866C>T	c.(7864-7866)ACC>ACT	p.T2622T	MYO15A_uc010vxi.1_5'Flank|MYO15A_uc010vxj.1_5'Flank|MYO15A_uc010vxk.1_5'Flank	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2622	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GGCAGATGACCCACCTGGCAG	0.602													T	18055238	T	T	18055238	2	4	160	1	0	0	0	0	0	0	0	1	10063	610	22	3		3	MYO15A	17	18055238	Silent	SNP	C	TCGA-19-2631-01A-01D-1353-08		18055238	63139972	86	11423											
LLGL1	3996	broad.mit.edu	37	chr17	18138556	18138556	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggcccacgtggccagtgtccCcgccaagctgtgggcccgca	14	17	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr17:18138556C>G	uc002gsp.2	+	10	1275	c.1214C>G	c.(1213-1215)CCC>CGC	p.P405R		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	405	WD 8.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					GCCAGTGTCCCCGCCAAGCTG	0.672													G	18138556	G	G	18138556	3	3	160	1	0	0	0	0	1	0	0	0	8833	623	22	5	1252	5	LLGL1	17	18138556	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	83318	18138556	63056654	87	11424											
KCNJ12	3768	broad.mit.edu	37	chr17	21319068	21319068	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcggccttcctcttctccatCgagacgcagaccaccatcgg	9	17	2	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr17:21319068C>T	uc002gyv.1	+	3	1119	c.414C>T	c.(412-414)ATC>ATT	p.I138I		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	138					blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TCTTCTCCATCGAGACGCAGA	0.672										Prostate(3;0.18)			T	21319068	T	T	21319068	2	4	160	1	0	0	0	0	0	0	0	1	8046	874	31	2		2	KCNJ12	17	21319068	Silent	SNP	C	TCGA-19-2631-01A-01D-1353-08	3180512	21319068	59876142	88	11425											
ACCN1	40	broad.mit.edu	37	chr17	31352958	31352958	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgacctagggcaggctctGcacactccttgtgctgctca	10	14	2	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr17:31352958G>A	uc002hhu.2	-	5	1302	c.1028C>T	c.(1027-1029)GCA>GTA	p.A343V	ACCN1_uc002hht.2_Missense_Mutation_p.A394V	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	343	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GGCAGGCTCTGCACACTCCTT	0.532													A	31352958	A	A	31352958	3	1	160	1	0	0	0	0	1	0	0	0	128	1319	46	3	534	3	ACCN1	17	31352958	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	10033890	31352958	49842252	89	11426											
GAS2L2	246176	broad.mit.edu	37	chr17	34074081	34074081	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcccccgtccctgctccccGttccctgcggggtctggggg	15	18	1	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr17:34074081G>A	uc002hjv.1	-	5	1067	c.1039C>T	c.(1039-1041)CGG>TGG	p.R347W		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	347					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCTGCTCCCCGTTCCCTGCGG	0.612													A	34074081	A	A	34074081	3	1	160	1	0	0	0	0	1	0	0	0	6247	1144	40	1	1611	1	GAS2L2	17	34074081	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	2721123	34074081	47121129	90	11427											
TAF15	8148	broad.mit.edu	37	chr17	34151174	34151174	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ggcgtgggggatatgacaagGatggaagaggtcctatgaca	17	5	0	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr17:34151174G>T	uc002hkd.2	+	7	663	c.577G>T	c.(577-579)GAT>TAT	p.D193Y	TAF15_uc010ctw.1_RNA|TAF15_uc002hkc.2_Missense_Mutation_p.D190Y	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	193	Gln/Gly/Ser/Tyr-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		ATATGACAAGGATGGAAGAGG	0.428			T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								T	34151174	T	T	34151174	3	4	160	1	0	0	0	0	1	0	0	0	15515	1174	41	5	603	5	TAF15	17	34151174	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	77093	34151174	47044036	91	11428											
KCNH6	81033	broad.mit.edu	37	chr17	61607575	61607575	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caagtgcagcagccgcagctTgtcccagcgcctgttgtccc	11	16	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr17:61607575T>C	uc002jay.2	+	3	511	c.431T>C	c.(430-432)TTG>TCG	p.L144S	KCNH6_uc002jax.1_Missense_Mutation_p.L144S|KCNH6_uc010wpl.1_Missense_Mutation_p.L21S|KCNH6_uc010wpm.1_Missense_Mutation_p.L144S|KCNH6_uc002jaz.1_Missense_Mutation_p.L144S	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	144	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	AGCCGCAGCTTGTCCCAGCGC	0.642													C	61607575	C	C	61607575	3	2	160	1	0	0	0	0	1	0	0	0	8036	1821	63	4	441	4	KCNH6	17	61607575	Missense_Mutation	SNP	T	TCGA-19-2631-01A-01D-1353-08	27456401	61607575	19587635	92	11429											
THOC1	9984	broad.mit.edu	37	chr18	247872	247874	+	In_Frame_Del	DEL	TCT	-	-													gagaaaagttttccatgaaaTcttctcatagcattgcacag							TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr18:247872_247874delTCT	uc002kkj.3	-	10	801_803	c.761_763delAGA	c.(760-765)AAGATT>ATT	p.K254del	THOC1_uc002kkk.3_RNA|THOC1_uc002kkl.2_In_Frame_Del_p.K254del	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	THO complex 1	254					apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				TTCCATGAAATCTTCTCATAGCA	0.35													-	247874	-	-	247872	7	5	160	1	0	1	0	1	0	0	0	0	15861	1435	50	0	1258	0	THOC1	18	247872	In_Frame_Del	DEL	TCT	TCGA-19-2631-01A-01D-1353-08		247872	77829376	93	11430											
KIAA1012	22878	broad.mit.edu	37	chr18	29496353	29496353	+	Frame_Shift_Del	DEL	A	-	-													aattcgatgctgttcttgtgAcaactttgaaaactgttcca							TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr18:29496353delA	uc002kxc.3	-	4	863	c.499delT	c.(499-501)TCAfs	p.S167fs	KIAA1012_uc002kxb.3_Frame_Shift_Del_p.S113fs|KIAA1012_uc002kxd.3_RNA|KIAA1012_uc002kxe.2_Frame_Shift_Del_p.S167fs	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	167					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TGTTCTTGTGACAACTTTGAA	0.348													-	29496353	-	-	29496353	7	5	160	1	0	1	0	1	0	0	0	0	8204	275	10	0	3912	0	KIAA1012	18	29496353	Frame_Shift_Del	DEL	A	TCGA-19-2631-01A-01D-1353-08	29248481	29496353	48580895	94	11431											
PSTPIP2	9050	broad.mit.edu	37	chr18	43572096	43572096	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaatctgtccagttttgcGttgattcacaaagtattcaa	8	7	3	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr18:43572096G>A	uc002lbp.3	-	11	910	c.814C>T	c.(814-816)CGC>TGC	p.R272C	PSTPIP2_uc002lbq.3_Intron	NM_024430	NP_077748	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting	272						membrane				ovary(1)	1						CCAGTTTTGCGTTGATTCACA	0.388													A	43572096	A	A	43572096	3	1	160	1	0	0	0	0	1	0	0	0	12722	1145	40	1	206	1	PSTPIP2	18	43572096	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	14075743	43572096	34505152	95	11432											
DENND1C	79958	broad.mit.edu	37	chr19	6477231	6477231	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tccccgagccccgctcaccgGcttgctattcccccgggtag	10	19	1	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr19:6477231G>C	uc002mfe.2	-	8	603	c.511C>G	c.(511-513)CCG>GCG	p.P171A	DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Missense_Mutation_p.P127A	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	171	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						CCGCTCACCGGCTTGCTATTC	0.667													C	6477231	C	C	6477231	3	2	160	1	0	0	0	0	1	0	0	0	4428	1203	42	5	1958	5	DENND1C	19	6477231	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08		6477231	52651752	96	11433											
MUC16	94025	broad.mit.edu	37	chr19	8997532	8997532	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatagcaccaggagagggctGgcagctgtcgtggaggtggg	19	7	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr19:8997532G>A	uc002mkp.2	-	59	41094	c.40890C>T	c.(40888-40890)GCC>GCT	p.A13630A	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.A447A|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAGAGGGCTGGCAGCTGTCG	0.468													A	8997532	A	A	8997532	2	1	160	1	0	0	0	0	0	0	0	1	9973	1335	47	3		3	MUC16	19	8997532	Silent	SNP	G	TCGA-19-2631-01A-01D-1353-08	2520301	8997532	50131451	97	11434											
FBXL12	54850	broad.mit.edu	37	chr19	9922084	9922084	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcggggacgcggtccagcaCgatgcattcaagcaggggca	17	11	1	0	rs61753275		TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr19:9922084C>T	uc002mme.2	-	3	711	c.469G>A	c.(469-471)GTG>ATG	p.V157M	FBXL12_uc002mmd.2_Missense_Mutation_p.V104M|FBXL12_uc002mmf.2_Missense_Mutation_p.V104M|FBXL12_uc002mmg.2_Missense_Mutation_p.V104M|FBXL12_uc002mmh.2_Missense_Mutation_p.V104M	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	157							protein binding			lung(1)|kidney(1)	2						CGGTCCAGCACGATGCATTCA	0.667													T	9922084	T	T	9922084	3	4	160	1	0	0	0	0	1	0	0	0	5708	536	19	1	515	1	FBXL12	19	9922084	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	924552	9922084	49206899	98	11435											
B3GNT3	10331	broad.mit.edu	37	chr19	17919127	17919127	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctggaggcacagactcacGgagacatcctgcagtgggac	14	11	1	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr19:17919127G>A	uc002nhk.1	+	2	596	c.511G>A	c.(511-513)GGA>AGA	p.G171R	B3GNT3_uc002nhl.1_Missense_Mutation_p.G171R|B3GNT3_uc010ebd.1_Missense_Mutation_p.G171R|B3GNT3_uc010ebe.1_Missense_Mutation_p.G171R	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	171	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						ACAGACTCACGGAGACATCCT	0.637													A	17919127	A	A	17919127	3	1	160	1	0	0	0	0	1	0	0	0	1258	1117	39	2	513	2	B3GNT3	19	17919127	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	7997043	17919127	41209856	99	11436											
SLC5A5	6528	broad.mit.edu	37	chr19	17986765	17986765	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtcccatgctgcagggcgGcatgaaggctgtggtctgga	16	10	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr19:17986765G>A	uc002nhr.3	+	5	895	c.548G>A	c.(547-549)GGC>GAC	p.G183D		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	183	Helical; (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CTGCAGGGCGGCATGAAGGCT	0.557													A	17986765	A	A	17986765	3	1	160	1	0	0	0	0	1	0	0	0	14668	1203	42	3	566	3	SLC5A5	19	17986765	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	67638	17986765	41142218	100	11437											
FAM187B	148109	broad.mit.edu	37	chr19	35718991	35718991	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actggacgtggcaggcttccAcctgcagctcaggccgcaag	13	14	1	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr19:35718991A>C	uc002nyk.1	-	1	638	c.593T>G	c.(592-594)GTG>GGG	p.V198G		NM_152481	NP_689694	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	198	Extracellular (Potential).					integral to membrane				ovary(2)	2						GCAGGCTTCCACCTGCAGCTC	0.542													C	35718991	C	C	35718991	3	2	160	1	0	0	0	0	1	0	0	0	5513	159	6	5	524	5	FAM187B	19	35718991	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08	17732226	35718991	23409992	101	11438											
SYMPK	8189	broad.mit.edu	37	chr19	46338456	46338456	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggaaggaggctggcatggCctcgggtaggtacaccatgc	16	10	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr19:46338456C>T	uc002pdn.2	-	11	1518	c.1273G>A	c.(1273-1275)GCC>ACC	p.A425T	SYMPK_uc002pdo.1_Missense_Mutation_p.A425T|SYMPK_uc002pdp.1_Missense_Mutation_p.A425T|SYMPK_uc002pdq.1_Missense_Mutation_p.A425T	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	425					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GCTGGCATGGCCTCGGGTAGG	0.498													T	46338456	T	T	46338456	3	4	160	1	0	0	0	0	1	0	0	0	15436	739	26	3	2619	3	SYMPK	19	46338456	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	10619465	46338456	12790527	102	11439											
FAM83E	54854	broad.mit.edu	37	chr19	49106813	49106813	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttaggtcccacatggagcGgctgggccgggccggggggc	20	12	0	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr19:49106813G>A	uc002pjn.2	-	4	1179	c.1114C>T	c.(1114-1116)CGC>TGC	p.R372C		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	372										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CACATGGAGCGGCTgggccgg	0.517													A	49106813	A	A	49106813	3	1	160	1	0	0	0	0	1	0	0	0	5637	1116	39	2	330	2	FAM83E	19	49106813	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	2768357	49106813	10022170	103	11440											
ZNF845	91664	broad.mit.edu	37	chr19	53854361	53854361	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	atcagcttggatcaagctttCattcgcatctgcctgaactc	7	12	4	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr19:53854361C>A	uc010ydv.1	+	4	550	c.433C>A	c.(433-435)CAT>AAT	p.H145N	ZNF845_uc010ydw.1_Missense_Mutation_p.H145N	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATCAAGCTTTCATTCGCATCT	0.428													A	53854361	A	A	53854361	3	1	160	1	0	0	0	0	1	0	0	0	18188	826	29	5	443	5	ZNF845	19	53854361	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	4747548	53854361	5274622	104	11441											
SEC23B	10483	broad.mit.edu	37	chr20	18511418	18511418	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attttaatggagatttccgaAtggcatttggtgctactttg	10	5	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr20:18511418A>G	uc002wqz.1	+	10	1647	c.1204A>G	c.(1204-1206)ATG>GTG	p.M402V	SEC23B_uc002wra.1_Missense_Mutation_p.M402V|SEC23B_uc002wrb.1_Missense_Mutation_p.M402V|SEC23B_uc010zsb.1_Missense_Mutation_p.M384V|SEC23B_uc002wrc.1_Missense_Mutation_p.M402V	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	402					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						AGATTTCCGAATGGCATTTGG	0.274													G	18511418	G	G	18511418	3	3	160	1	0	0	0	0	1	0	0	0	13992	101	4	4	1238	4	SEC23B	20	18511418	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08		18511418	44514102	105	11442											
SRC	6714	broad.mit.edu	37	chr20	36030005	36030005	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggtctctctctgcccagGgagtttgctggactttctca	11	12	3	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr20:36030005G>A	uc002xgx.2	+	11	1489	c.1040G>A	c.(1039-1041)GGG>GAG	p.G347E	SRC_uc002xgy.2_Missense_Mutation_p.G347E	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	347	Protein kinase.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	CTCTGCCCAGGGAGTTTGCTG	0.617													A	36030005	A	A	36030005	3	1	160	1	0	0	0	0	1	0	0	0	15133	1246	43	3	1070	3	SRC	20	36030005	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	17518587	36030005	26995515	106	11443											
KIAA1755	85449	broad.mit.edu	37	chr20	36841631	36841631	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcttgtgggagcctttgCcgtcttcagcctctgcagcc	12	14	3	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr20:36841631C>T	uc002xhy.1	-	14	3688	c.3416G>A	c.(3415-3417)GGC>GAC	p.G1139D	KIAA1755_uc002xhv.1_Missense_Mutation_p.G203D|KIAA1755_uc002xhw.1_Missense_Mutation_p.G194D|KIAA1755_uc002xhx.1_Missense_Mutation_p.G417D	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	1139										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GGAGCCTTTGCCGTCTTCAGC	0.652													T	36841631	T	T	36841631	3	4	160	1	0	0	0	0	1	0	0	0	8257	739	26	3	190	3	KIAA1755	20	36841631	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	811626	36841631	26183889	107	11444											
LPIN3	64900	broad.mit.edu	37	chr20	39986528	39986528	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcccccactctcagaaatggGtacaagttcctgtactgctc	7	14	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr20:39986528G>T	uc002xjx.2	+	17	2137	c.2046G>T	c.(2044-2046)GGG>GGT	p.G682G	LPIN3_uc010ggh.2_Silent_p.G683G|LPIN3_uc010zwf.1_RNA	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	lipin 3	682	C-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.000739)				TCAGAAATGGGTACAAGTTCC	0.622													T	39986528	T	T	39986528	2	4	160	1	0	0	0	0	0	0	0	1	8920	1248	44	5		5	LPIN3	20	39986528	Silent	SNP	G	TCGA-19-2631-01A-01D-1353-08	3144897	39986528	23038992	108	11445											
DPM1	8813	broad.mit.edu	37	chr20	49574949	49574949	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacgatgagcggcaggttctCgcgctcgttgtaggtaggta	15	9	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr20:49574949C>T	uc002xvw.1	-	1	112	c.112G>A	c.(112-114)GAG>AAG	p.E38K	DPM1_uc002xvx.1_RNA|MOCS3_uc002xvy.1_5'Flank	NM_003859	NP_003850	O60762	DPM1_HUMAN	dolichyl-phosphate mannosyltransferase 1	38					C-terminal protein lipidation|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|protein N-linked glycosylation via asparagine|protein O-linked mannosylation	dolichol-phosphate-mannose synthase complex|endoplasmic reticulum membrane|membrane fraction	dolichyl-phosphate beta-D-mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding			ovary(1)	1						GGCAGGTTCTCGCGCTCGTTG	0.582													T	49574949	T	T	49574949	3	4	160	1	0	0	0	0	1	0	0	0	4724	893	31	2	706	2	DPM1	20	49574949	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	9588421	49574949	13450571	109	11446											
NFATC2	4773	broad.mit.edu	37	chr20	50007936	50007936	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctataatggcttcttttaCgtctgatttctggcaggagg	11	7	3	1	rs148642400		TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr20:50007936C>T	uc002xwd.2	-	10	2995	c.2775G>A	c.(2773-2775)ACG>ACA	p.T925T	NFATC2_uc002xwc.2_3'UTR|NFATC2_uc010zyv.1_3'UTR|NFATC2_uc010zyw.1_Silent_p.T706T|NFATC2_uc010zyx.1_3'UTR|NFATC2_uc010zyy.1_3'UTR|NFATC2_uc010zyz.1_Silent_p.T706T|NFATC2_uc002xwe.2_Silent_p.T905T	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	925					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GCTTCTTTTACGTCTGATTTC	0.498													T	50007936	T	T	50007936	2	4	160	1	0	0	0	0	0	0	0	1	10362	523	19	1		1	NFATC2	20	50007936	Silent	SNP	C	TCGA-19-2631-01A-01D-1353-08	432987	50007936	13017584	110	11447											
TMPRSS15	5651	broad.mit.edu	37	chr21	19651292	19651292	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ataatttaccttgatatacaAccgtcccccaaccagcaata	3	13	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr21:19651292A>T	uc002ykw.2	-	23	2784	c.2753T>A	c.(2752-2754)GTT>GAT	p.V918D		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	918	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TTGATATACAACCGTCCCCCA	0.328													T	19651292	T	T	19651292	3	4	160	1	0	0	0	0	1	0	0	0	16243	43	2	5	318	5	TMPRSS15	21	19651292	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08		19651292	28478603	111	11448											
IFNGR2	3460	broad.mit.edu	37	chr21	34805024	34805024	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tcgtgtcctctttttagcctCcactgagcttcagcaagtca	7	13	3	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chr21:34805024C>G	uc002yrp.3	+	6	1373	c.725C>G	c.(724-726)TCC>TGC	p.S242C	IFNGR2_uc002yrq.3_Missense_Mutation_p.S261C|IFNGR2_uc010gma.2_Missense_Mutation_p.S163C|IFNGR2_uc002yrr.3_Missense_Mutation_p.S163C|TMEM50B_uc002yrs.1_RNA	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	242	Extracellular (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	TTTTTAGCCTCCACTGAGCTT	0.468													G	34805024	G	G	34805024	3	3	160	1	0	0	0	0	1	0	0	0	7550	855	30	5	747	5	IFNGR2	21	34805024	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	15153732	34805024	13324871	112	11449											
ZBED1	9189	broad.mit.edu	37	chrX	2407889	2407889	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cggcattgaaggtgtggcccAggcagggcatgtgcactgcg	17	10	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:2407889A>G	uc004cqg.2	-	2	1073	c.872T>C	c.(871-873)CTG>CCG	p.L291P	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.L291P	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	291						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTGTGGCCCAGGCAGGGCAT	0.647													G	2407889	G	G	2407889	3	3	160	1	0	0	0	0	1	0	0	0	17514	188	7	4	1216	4	ZBED1	23	2407889	Missense_Mutation	SNP	A	TCGA-19-2631-01A-01D-1353-08		2407889	152862671	113	11450											
ARX	170302	broad.mit.edu	37	chrX	25031255	25031255	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccttgggtgacagctccccgCcctctgtggccactgcagcg	12	17	1	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:25031255C>G	uc004dbp.3	-	2	1068	c.857G>C	c.(856-858)GGC>GCC	p.G286A		NM_139058	NP_620689	Q96QS3	ARX_HUMAN	aristaless related homeobox	286						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CAGCTCCCCGCCCTCTGTGGC	0.701													G	25031255	G	G	25031255	3	3	160	1	0	0	0	0	1	0	0	0	1004	739	26	5	847	5	ARX	23	25031255	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	22623366	25031255	130239305	114	11451											
DMD	1756	broad.mit.edu	37	chrX	32305784	32305784	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctatgaataatgtcaatcCgacctgagctttgttgtaga	9	7	1	3			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:32305784C>T	uc004dda.1	-	43	6396	c.6152G>A	c.(6151-6153)CGG>CAG	p.R2051Q	DMD_uc004dcw.2_Missense_Mutation_p.R707Q|DMD_uc004dcx.2_Missense_Mutation_p.R710Q|DMD_uc004dcz.2_Missense_Mutation_p.R1928Q|DMD_uc004dcy.1_Missense_Mutation_p.R2047Q|DMD_uc004ddb.1_Missense_Mutation_p.R2043Q|DMD_uc010ngo.1_Intron|DMD_uc010ngn.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2051	Spectrin 14.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AATGTCAATCCGACCTGAGCT	0.348													T	32305784	T	T	32305784	3	4	160	1	0	0	0	0	1	0	0	0	4580	652	23	2	5201	2	DMD	23	32305784	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	7274529	32305784	122964776	115	11452											
RBM3	5935	broad.mit.edu	37	chrX	48433596	48433596	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctgaagaaggaaagctcttcGtgggagggctcaactttaac	12	8	2	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:48433596G>C	uc004dkf.1	+	2	167	c.28G>C	c.(28-30)GTG>CTG	p.V10L	RBM3_uc004dkd.1_RNA|RBM3_uc004dkg.2_Missense_Mutation_p.V10L	NM_006743	NP_006734	P98179	RBM3_HUMAN	RNA binding motif protein 3	10	RRM.				positive regulation of translation	dendrite|nucleus	nucleotide binding|RNA binding			ovary(1)	1						AAAGCTCTTCGTGGGAGGGCT	0.502											OREG0019765	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	48433596	C	C	48433596	3	2	160	1	0	0	0	0	1	0	0	0	13129	1145	40	5	30	5	RBM3	23	48433596	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	16127812	48433596	106836964	116	11453											
CLCN5	1184	broad.mit.edu	37	chrX	49851112	49851112	+	Frame_Shift_Del	DEL	A	-	-													actattttatgtggagtttcAcaccccatggcatctctttg							TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:49851112delA	uc004dos.1	+	8	1180	c.932delA	c.(931-933)CACfs	p.H311fs	CLCN5_uc004dor.1_Frame_Shift_Del_p.H381fs|CLCN5_uc004doq.1_Frame_Shift_Del_p.H381fs|CLCN5_uc004dot.1_Frame_Shift_Del_p.H311fs	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	311					excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					GTGGAGTTTCACACCCCATGG	0.498													-	49851112	-	-	49851112	7	5	160	1	0	1	0	1	0	0	0	0	3466	159	6	0	1176	0	CLCN5	23	49851112	Frame_Shift_Del	DEL	A	TCGA-19-2631-01A-01D-1353-08	1417516	49851112	105419448	117	11454											
USP51	158880	broad.mit.edu	37	chrX	55513943	55513943	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatgcagttacagcagttgGggttattggcctcctgccca	12	10	0	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:55513943G>A	uc004dun.1	-	2	1509	c.1430C>T	c.(1429-1431)CCC>CTC	p.P477L	USP51_uc011moo.1_Missense_Mutation_p.P181L	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	477					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						ACAGCAGTTGGGGTTATTGGC	0.478													A	55513943	A	A	55513943	3	1	160	1	0	0	0	0	1	0	0	0	17080	1232	43	3	709	3	USP51	23	55513943	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	5662831	55513943	99756617	118	11455											
NRK	203447	broad.mit.edu	37	chrX	105159747	105159747	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagagatctccttctgtgcCtaacaaccaggatcatgcac	8	12	3	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:105159747C>T	uc004emd.2	+	15	2678	c.2375C>T	c.(2374-2376)CCT>CTT	p.P792L	NRK_uc010npc.1_Missense_Mutation_p.P460L	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	792							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						CCTTCTGTGCCTAACAACCAG	0.313										HNSCC(51;0.14)			T	105159747	T	T	105159747	3	4	160	1	0	0	0	0	1	0	0	0	10655	681	24	3	2433	3	NRK	23	105159747	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	49645804	105159747	50110813	119	11456											
LHFPL1	340596	broad.mit.edu	37	chrX	111914414	111914414	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcattgaagctggcatagcGcccacattcttccaccatga	9	13	1	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:111914414G>A	uc004epq.2	-	2	538	c.205C>T	c.(205-207)CGC>TGC	p.R69C	LHFPL1_uc004epp.2_Missense_Mutation_p.R92C|LHFPL1_uc010nqa.2_Intron|LHFPL1_uc010nqb.2_Missense_Mutation_p.R69C	NM_178175	NP_835469	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1 precursor	69						integral to membrane					0						CTGGCATAGCGCCCACATTCT	0.592													A	111914414	A	A	111914414	3	1	160	1	0	0	0	0	1	0	0	0	8764	1087	38	1	469	1	LHFPL1	23	111914414	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	6754667	111914414	43356146	120	11457											
HTR2C	3358	broad.mit.edu	37	chrX	114082719	114082719	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatagccgtttcaattcgcGgactaaggccatcatgaaga	10	10	2	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:114082719G>A	uc004epu.1	+	5	1231	c.503G>A	c.(502-504)CGG>CAG	p.R168Q	HTR2C_uc010nqc.1_Missense_Mutation_p.R168Q|HTR2C_uc004epv.1_Intron	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	168	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	TTCAATTCGCGGACTAAGGCC	0.408													A	114082719	A	A	114082719	3	1	160	1	0	0	0	0	1	0	0	0	7443	1116	39	2	513	2	HTR2C	23	114082719	Missense_Mutation	SNP	G	TCGA-19-2631-01A-01D-1353-08	2168305	114082719	41187841	121	11458											
MAGEC3	139081	broad.mit.edu	37	chrX	140985023	140985023	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atcaagaagtataaggactaTtttcccatgatcttcgggaa	8	7	2	2			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:140985023T>C	uc011mwp.1	+	7	1479	c.1479T>C	c.(1477-1479)TAT>TAC	p.Y493Y	MAGEC3_uc004fbs.2_Silent_p.Y195Y|MAGEC3_uc010nsj.2_Silent_p.Y195Y	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	493	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATAAGGACTATTTTCCCATGA	0.438													C	140985023	C	C	140985023	2	2	160	1	0	0	0	0	0	0	0	1	9182	1500	52	4		4	MAGEC3	23	140985023	Silent	SNP	T	TCGA-19-2631-01A-01D-1353-08	26902304	140985023	14285537	122	11459											
MTMR1	8776	broad.mit.edu	37	chrX	149924177	149924177	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaggatgtatatacaaagaCgatatctttatggtcgtata	8	5	2	1			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:149924177C>T	uc004fei.2	+	14	1808	c.1673C>T	c.(1672-1674)ACG>ATG	p.T558M	MTMR1_uc011mya.1_Missense_Mutation_p.T464M|MTMR1_uc004feh.1_Missense_Mutation_p.T566M|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_RNA	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	558	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TATACAAAGACGATATCTTTA	0.323													T	149924177	T	T	149924177	3	4	160	1	0	0	0	0	1	0	0	0	9938	536	19	1	1727	1	MTMR1	23	149924177	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	8939154	149924177	5346383	123	11460											
FAM3A	60343	broad.mit.edu	37	chrX	153736149	153736149	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgctgcaactcacctccggcCcacatgtcaaaggcccgggc	10	18	2	0			TCGA-19-2631-01A-01D-1353-08	TCGA-19-2631-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	2c5bd78d-89c0-4828-903d-4fe5a3088440	d235b579-9d3f-49e3-bdcf-6c3ae9975993	g.chrX:153736149C>A	uc004fls.1	-	6	655	c.378G>T	c.(376-378)TGG>TGT	p.W126C	FAM3A_uc004flt.1_Missense_Mutation_p.W140C|FAM3A_uc011mzp.1_Intron|FAM3A_uc004flu.1_Intron|FAM3A_uc011mzq.1_Missense_Mutation_p.W126C|FAM3A_uc004flw.1_Missense_Mutation_p.W126C	NM_021806	NP_068578	P98173	FAM3A_HUMAN	family 3, member A protein precursor	126						extracellular region				large_intestine(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CACCTCCGGCCCACATGTCAA	0.627													A	153736149	A	A	153736149	3	1	160	1	0	0	0	0	1	0	0	0	5556	624	22	5	330	5	FAM3A	23	153736149	Missense_Mutation	SNP	C	TCGA-19-2631-01A-01D-1353-08	3811972	153736149	1534411	124	11461											
CHD5	26038	broad.mit.edu	37	chr1	6181182	6181182	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacctctcggcagctgctccGgggagggcggggccttctcc	15	15	2	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr1:6181182G>A	uc001amb.1	-	33	4995	c.4895C>T	c.(4894-4896)CCG>CTG	p.P1632L	CHD5_uc001alz.1_Missense_Mutation_p.P489L|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1632					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CAGCTGCTCCGGGGAGGGCGG	0.652													A	6181182	A	A	6181182	3	1	161	1	0	0	0	0	1	0	0	0	3328	1116	39	2	1005	2	CHD5	1	6181182	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08		6181182	243069439	1	11462											
RORC	6097	broad.mit.edu	37	chr1	151789268	151789268	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgcgttacagcgctggctcCggcggaagaagccctgggga	16	13	0	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr1:151789268C>T	uc001ezh.2	-	4	278	c.170G>A	c.(169-171)CGG>CAG	p.R57Q	RORC_uc001ezg.2_Missense_Mutation_p.R36Q|RORC_uc010pdo.1_Missense_Mutation_p.R111Q|RORC_uc010pdp.1_Missense_Mutation_p.R57Q	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	57	Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCGCTGGCTCCGGCGGAAGAA	0.637													T	151789268	T	T	151789268	3	4	161	1	0	0	0	0	1	0	0	0	13530	652	23	2	1418	2	RORC	1	151789268	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	145608086	151789268	97461353	2	11463											
RPTN	126638	broad.mit.edu	37	chr1	152127687	152127687	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaatccctgtccctggttttGgtacccttcctgtcctggag	10	13	0	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr1:152127687G>T	uc001ezs.1	-	3	1953	c.1888C>A	c.(1888-1890)CAA>AAA	p.Q630K		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	630	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						CCCTGGTTTTGGTACCCTTCC	0.498													T	152127687	T	T	152127687	3	4	161	1	0	0	0	0	1	0	0	0	13664	1357	47	5	470	5	RPTN	1	152127687	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	338419	152127687	97122934	3	11464											
HMCN1	83872	broad.mit.edu	37	chr1	185958748	185958748	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaccaatacagccggctaCgccaaaaggaaagtgcagct	10	13	0	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr1:185958748C>T	uc001grq.1	+	21	3406	c.3177C>T	c.(3175-3177)TAC>TAT	p.Y1059Y	HMCN1_uc001grr.1_Silent_p.Y400Y	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1059	Ig-like C2-type 7.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAGCCGGCTACGCCAAAAGGA	0.483													T	185958748	T	T	185958748	2	4	161	1	0	0	0	0	0	0	0	1	7220	547	19	1		1	HMCN1	1	185958748	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	33831061	185958748	63291873	4	11465											
IGFN1	91156	broad.mit.edu	37	chr1	201182690	201182690	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggagagaggagagatgctaCccggagttccacatccagat	13	9	0	3			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr1:201182690C>T	uc001gwc.2	+	1	921	c.149C>T	c.(148-150)ACC>ATC	p.T50I	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						AGAGATGCTACCCGGAGTTCC	0.562													T	201182690	T	T	201182690	3	4	161	1	0	0	0	0	1	0	0	0	7590	507	18	3	8711	3	IGFN1	1	201182690	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	15223942	201182690	48067931	5	11466											
GTF2A1L	11036	broad.mit.edu	37	chr2	48960045	48960045	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccgaaggcattcccaagaaGgacatcgtttaacacctaaa	7	12	0	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr2:48960045G>C	uc002rwt.2	+	9	1409	c.1343G>C	c.(1342-1344)AGG>ACG	p.R448T	LHCGR_uc002rwu.3_Intron|LHCGR_uc002rwv.2_Intron	NM_172196	NP_751946	Q9UNN4	TF2AY_HUMAN	general transcription factor IIA, 1-like isoform	Error:Variant_position_missing_in_Q9UNN4_after_alignment					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	transcription factor TFIIA complex	DNA binding|transcription coactivator activity				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTCCCAAGAAGGACATCGTTT	0.249													C	48960045	C	C	48960045	3	2	161	1	0	0	0	0	1	0	0	0	6853	1000	35	5	1489	5	GTF2A1L	2	48960045	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08		48960045	194239328	6	11467											
DPP10	57628	broad.mit.edu	37	chr2	116548904	116548904	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcccaaagattttatggacCgaaaccagtatgctcttctg	7	10	2	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr2:116548904C>T	uc002tla.1	+	19	2129	c.1672C>T	c.(1672-1674)CGA>TGA	p.R558*	DPP10_uc002tlb.1_Nonsense_Mutation_p.R508*|DPP10_uc002tlc.1_Nonsense_Mutation_p.R554*|DPP10_uc002tle.2_Nonsense_Mutation_p.R562*|DPP10_uc002tlf.1_Nonsense_Mutation_p.R551*	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	558	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TTTTATGGACCGAAACCAGTA	0.289													T	116548904	T	T	116548904	4	4	161	1	0	0	0	0	0	1	0	0	4727	644	23	2	1917	2	DPP10	2	116548904	Nonsense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	67588859	116548904	126650469	7	11468											
NCL	4691	broad.mit.edu	37	chr2	232325239	232325239	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgctttctgtttggccattTccttctttcgttttccaggt	7	11	2	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr2:232325239T>C	uc002vru.2	-	5	989	c.848A>G	c.(847-849)GAA>GGA	p.E283G	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	283					angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		TTTGGCCATTTCCTTCTTTCG	0.433													C	232325239	C	C	232325239	3	2	161	1	0	0	0	0	1	0	0	0	10226	1783	62	4	1324	4	NCL	2	232325239	Missense_Mutation	SNP	T	TCGA-19-4068-01A-01D-1353-08	115776335	232325239	10874134	8	11469											
SUSD5	26032	broad.mit.edu	37	chr3	33194586	33194586	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgggtggttgccatgatcGttgaggggatgtggttaggt	19	4	0	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr3:33194586G>A	uc003cfo.1	-	5	1956	c.1538C>T	c.(1537-1539)ACG>ATG	p.T513M		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	513	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						TGCCATGATCGTTGAGGGGAT	0.522													A	33194586	A	A	33194586	3	1	161	1	0	0	0	0	1	0	0	0	15408	1145	40	1	355	1	SUSD5	3	33194586	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08		33194586	164827844	9	11470											
VILL	50853	broad.mit.edu	37	chr3	38048114	38048114	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaccagcgccacgatcaacGggggcctgcgccgggaacaa	14	15	1	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr3:38048114G>T	uc003chj.2	+	19	2666	c.2380G>T	c.(2380-2382)GGG>TGG	p.G794W	VILL_uc003chl.2_Missense_Mutation_p.G794W	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	794	HP.				actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CACGATCAACGGGGGCCTGCG	0.672													T	38048114	T	T	38048114	3	4	161	1	0	0	0	0	1	0	0	0	17162	1116	39	5	2450	5	VILL	3	38048114	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	4853528	38048114	159974316	10	11471											
SHISA5	51246	broad.mit.edu	37	chr3	48510545	48510545	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatccatgtaggccgggttGtaaggaggctggctggcggg	19	8	0	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr3:48510545G>A	uc003ctp.1	-	6	818	c.684C>T	c.(682-684)TAC>TAT	p.Y228Y	SHISA5_uc003ctn.1_Nonsense_Mutation_p.Q97*|SHISA5_uc003ctm.1_Silent_p.Y125Y|SHISA5_uc011bbk.1_Nonsense_Mutation_p.Q137*|SHISA5_uc003cto.1_Silent_p.Y197Y|SHISA5_uc003ctq.1_Silent_p.Y221Y|SHISA5_uc003ctr.1_Silent_p.Y197Y|SHISA5_uc003cts.1_Silent_p.Y197Y|SHISA5_uc003ctt.2_3'UTR|SHISA5_uc003ctu.1_RNA|SHISA5_uc011bbl.1_Silent_p.Y126Y	NM_016479	NP_057563	Q8N114	SHSA5_HUMAN	scotin precursor	228	Cytoplasmic (Potential).|Pro-rich.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	signal transducer activity|WW domain binding				0						AGGCCGGGTTGTAAGGAGGCT	0.637													A	48510545	A	A	48510545	2	1	161	1	0	0	0	0	0	0	0	1	14283	1372	48	3		3	SHISA5	3	48510545	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	10462431	48510545	149511885	11	11472											
POC1A	25886	broad.mit.edu	37	chr3	52156395	52156395	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgcctgccaagccacttacCagattccccatggagctggc	9	15	0	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr3:52156395C>T	uc003dcu.2	-	9	1299	c.981G>A	c.(979-981)CTG>CTA	p.L327L	POC1A_uc003dcv.2_Silent_p.L289L|POC1A_uc003dcw.2_Silent_p.L327L	NM_015426	NP_056241	Q8NBT0	POC1A_HUMAN	WD repeat domain 51A isoform 1	327						centriole|microtubule basal body					0						AGCCACTTACCAGATTCCCCA	0.547													T	52156395	T	T	52156395	2	4	161	1	0	0	0	0	0	0	0	1	12175	608	21	3		3	POC1A	3	52156395	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	3645850	52156395	145866035	12	11473											
EPHA6	285220	broad.mit.edu	37	chr3	97124120	97124120	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gatcaagtactatgagaaagTaggtcttatttggagcttcc	10	6	2	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr3:97124120T>A	uc010how.1	+	6	1774	c.1731_splice	c.e6+2	p.K577_splice		NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a							integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TATGAGAAAGTAGGTCTTATT	0.353													A	97124120	A	A	97124120	5	1	161	1	0	0	0	0	0	0	1	0	5171	1652	57	5	1755	5	EPHA6	3	97124120	Splice_Site	SNP	T	TCGA-19-4068-01A-01D-1353-08	44967725	97124120	100898310	13	11474											
IMPG2	50939	broad.mit.edu	37	chr3	100964883	100964883	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gggaggaccagagctgaaatCaagtggtggaatactgctgg	16	6	1	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr3:100964883C>G	uc003duq.1	-	12	1509	c.1306G>C	c.(1306-1308)GAT>CAT	p.D436H	IMPG2_uc011bhe.1_Missense_Mutation_p.D299H	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	436	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GAGCTGAAATCAAGTGGTGGA	0.468													G	100964883	G	G	100964883	3	3	161	1	0	0	0	0	1	0	0	0	7729	826	29	5	2451	5	IMPG2	3	100964883	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	3840763	100964883	97057547	14	11475											
CASR	846	broad.mit.edu	37	chr3	122003194	122003194	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcaagtcccggaagctgcCggagaacttcaatgaagcca	10	12	2	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr3:122003194C>T	uc003eev.3	+	7	2765	c.2393C>T	c.(2392-2394)CCG>CTG	p.P798L	CASR_uc003eew.3_Missense_Mutation_p.P808L	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	798	Cytoplasmic (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CGGAAGCTGCCGGAGAACTTC	0.552													T	122003194	T	T	122003194	3	4	161	1	0	0	0	0	1	0	0	0	2682	652	23	2	2445	2	CASR	3	122003194	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	21038311	122003194	76019236	15	11476											
PLXNA1	5361	broad.mit.edu	37	chr3	126708342	126708342	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgagttccccattggctgCgagcaggcgggtgtggagta	17	8	0	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr3:126708342C>T	uc003ejg.2	+	1	841	c.837C>T	c.(835-837)TGC>TGT	p.C279C		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	302	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CCATTGGCTGCGAGCAGGCGG	0.662													T	126708342	T	T	126708342	2	4	161	1	0	0	0	0	0	0	0	1	12119	776	27	1		1	PLXNA1	3	126708342	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	4705148	126708342	71314088	16	11477											
THPO	7066	broad.mit.edu	37	chr3	184090840	184090840	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgtggtgggtggggcccGcctgacgcagagggtggacc	20	10	0	2	rs144953270		TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr3:184090840G>A	uc003fol.1	-	6	738	c.523C>T	c.(523-525)CGG>TGG	p.R175W	THPO_uc003fom.1_Missense_Mutation_p.R171W|THPO_uc003fon.2_Intron|THPO_uc011bro.1_Intron|THPO_uc003fop.2_Intron|THPO_uc011brp.1_Intron|THPO_uc011brq.1_Intron|THPO_uc003for.1_Intron|THPO_uc003fos.1_Intron	NM_000460	NP_000451	P40225	TPO_HUMAN	thrombopoietin precursor	175					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			ovary(1)	1	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGTGGGGCCCGCCTGACGCAG	0.562													A	184090840	A	A	184090840	3	1	161	1	0	0	0	0	1	0	0	0	15869	1087	38	1	542	1	THPO	3	184090840	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	57382498	184090840	13931590	17	11478											
DEFB131	644414	broad.mit.edu	37	chr4	9452176	9452176	+	Frame_Shift_Del	DEL	G	-	-													tgaacatgcaattagatactGtgctgacttcagcatctgct							TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr4:9452176delG	uc011bwt.1	+	2	149	c.149delG	c.(148-150)TGTfs	p.C50fs		NM_001040448	NP_001035538	P59861	DB131_HUMAN	defensin, beta 131 precursor	50					defense response to bacterium	extracellular region					0						ATTAGATACTGTGCTGACTTC	0.383													-	9452176	-	-	9452176	7	5	161	1	0	1	0	1	0	0	0	0	4416	1377	48	0	155	0	DEFB131	4	9452176	Frame_Shift_Del	DEL	G	TCGA-19-4068-01A-01D-1353-08		9452176	181702100	18	11479											
PLEKHG4B	153478	broad.mit.edu	37	chr5	163559	163559	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacagagaagaagctcccGctgtggcagcatgccaggag	14	12	0	2	rs114260538	byFrequency	TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr5:163559G>A	uc003jak.2	+	11	2354	c.2304G>A	c.(2302-2304)CCG>CCA	p.P768P		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	768					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGAAGCTCCCGCTGTGGCAGC	0.652													A	163559	A	A	163559	2	1	161	1	0	0	0	0	0	0	0	1	12072	1074	38	1		1	PLEKHG4B	5	163559	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08		163559	180751701	19	11480											
MAST4	375449	broad.mit.edu	37	chr5	65892596	65892596	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtcctctccgggtgcttcctCggccgagtcctcctcgggct	12	17	1	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr5:65892596C>T	uc003jur.3	+	1	421	c.113C>T	c.(112-114)TCG>TTG	p.S38L	MAST4_uc010iwz.2_Missense_Mutation_p.S38L	NM_198828	NP_942123	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	38						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GGTGCTTCCTCGGCCGAGTCC	0.731													T	65892596	T	T	65892596	3	4	161	1	0	0	0	0	1	0	0	0	9327	893	31	2	115	2	MAST4	5	65892596	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	65729037	65892596	115022664	20	11481											
TAF9	6880	broad.mit.edu	37	chr5	68647987	68647987	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ttactgggcagctgatgcacGatttcttccttgtaggatgc	11	9	1	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr5:68647987G>T	uc003jwa.2	-	5	512	c.420C>A	c.(418-420)ATC>ATA	p.I140I	TAF9_uc003jwb.2_Silent_p.I137I	NM_016283	NP_057367	Q16594	TAF9_HUMAN	TAF9 RNA polymerase II, TATA box binding	Error:Variant_position_missing_in_Q16594_after_alignment					histone H3 acetylation|negative regulation of apoptosis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cell growth|positive regulation of response to cytokine stimulus|positive regulation of transcription from RNA polymerase II promoter|response to interleukin-1|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	MLL1 complex|PCAF complex|pre-snoRNP complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	activating transcription factor binding|C2H2 zinc finger domain binding|p53 binding|transcription coactivator activity|transcription regulatory region DNA binding				0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		GCTGATGCACGATTTCTTCCT	0.373													T	68647987	T	T	68647987	2	4	161	1	0	0	0	0	0	0	0	1	15532	1048	37	5		5	TAF9	5	68647987	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	2755391	68647987	112267273	21	11482											
SLCO6A1	133482	broad.mit.edu	37	chr5	101794118	101794138	+	In_Frame_Del	DEL	TTCCAAGTTTCAGATCTTTAA	-	-													acataaatccttgatattagTtccaagtttcagatctttaa							TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr5:101794118_101794138delTTCCAAGTTTCAGATCTTTAA	uc003knn.2	-	6	1251_1271	c.1079_1099delTTAAAGATCTGAAACTTGGAA	c.(1078-1101)CTTAAAGATCTGAAACTTGGAACT>CCT	p.360_367LKDLKLGT>P	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_In_Frame_Del_p.360_367LKDLKLGT>P|SLCO6A1_uc003knq.2_In_Frame_Del_p.298_305LKDLKLGT>P	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	360_367	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TTGATATTAGTTCCAAGTTTCAGATCTTTAAGTCTGCTGTC	0.285													-	101794138	-	-	101794118	7	5	161	1	0	1	0	1	0	0	0	0	14732	1725	60	0	1092	0	SLCO6A1	5	101794118	In_Frame_Del	DEL	TTCCAAGTTTCAGATCTTTAA	TCGA-19-4068-01A-01D-1353-08	33146131	101794118	79121142	22	11483											
SEC24A	10802	broad.mit.edu	37	chr5	134033601	134033601	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttccaggttgtatttctcGgtattcagcaggtagtgtct	10	8	4	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr5:134033601G>A	uc003kzs.2	+	15	2408	c.2120G>A	c.(2119-2121)CGG>CAG	p.R707Q	SEC24A_uc011cxu.1_Missense_Mutation_p.R471Q	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	707					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGTATTTCTCGGTATTCAGCA	0.383													A	134033601	A	A	134033601	3	1	161	1	0	0	0	0	1	0	0	0	13994	1116	39	2	2178	2	SEC24A	5	134033601	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	32239483	134033601	46881659	23	11484											
SH3RF2	153769	broad.mit.edu	37	chr5	145435652	145435652	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttcagaaggtgatccacgGcaaagccgtcccttcaaatc	8	12	2	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr5:145435652G>A	uc003lnt.2	+	8	1669	c.1431G>A	c.(1429-1431)CGG>CGA	p.R477R	SH3RF2_uc011dbl.1_Silent_p.R477R|SH3RF2_uc011dbm.1_5'UTR|SH3RF2_uc003lnu.2_5'UTR|SH3RF2_uc011dbn.1_5'UTR	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	477							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGATCCACGGCAAAGCCGTC	0.562													A	145435652	A	A	145435652	2	1	161	1	0	0	0	0	0	0	0	1	14259	1190	42	3		3	SH3RF2	5	145435652	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	11402051	145435652	35479608	24	11485											
TRIM41	90933	broad.mit.edu	37	chr5	180651777	180651777	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagccacaaacagcacagcGtggtgccattggaggaggtg	16	9	0	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr5:180651777G>A	uc003mne.1	+	1	1472	c.778G>A	c.(778-780)GTG>ATG	p.V260M	uc003mnb.1_Missense_Mutation_p.R39C|TRIM41_uc003mnc.1_Missense_Mutation_p.V260M|TRIM41_uc003mnd.1_Missense_Mutation_p.V260M|TRIM41_uc003mnf.1_RNA	NM_033549	NP_291027	Q8WV44	TRI41_HUMAN	tripartite motif-containing 41 isoform 1	260	B box-type.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding				0	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAGCACAGCGTGGTGCCATT	0.552													A	180651777	A	A	180651777	3	1	161	1	0	0	0	0	1	0	0	0	16513	1145	40	1	780	1	TRIM41	5	180651777	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	35216125	180651777	263483	25	11486											
MCM3	4172	broad.mit.edu	37	chr6	52141940	52141940	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagtggtggggatagctcGgggtgcagtgcaaagcacat	17	8	0	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr6:52141940G>A	uc003pan.1	-	8	1200	c.1090C>T	c.(1090-1092)CGA>TGA	p.R364*	MCM3_uc011dwu.1_Nonsense_Mutation_p.R318*	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	364	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					GGGATAGCTCGGGGTGCAGTG	0.597													A	52141940	A	A	52141940	4	1	161	1	0	0	0	0	0	1	0	0	9387	1124	39	2	1376	2	MCM3	6	52141940	Nonsense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08		52141940	118973127	26	11487											
BMP5	653	broad.mit.edu	37	chr6	55684540	55684540	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctccggtccttgtatatcCggaattcagctgctgtcact	9	12	2	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr6:55684540C>T	uc003pcq.2	-	2	1308	c.596G>A	c.(595-597)CGG>CAG	p.R199Q	BMP5_uc011dxf.1_Missense_Mutation_p.R199Q	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	199					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTTGTATATCCGGAATTCAGC	0.368													T	55684540	T	T	55684540	3	4	161	1	0	0	0	0	1	0	0	0	1463	652	23	2	792	2	BMP5	6	55684540	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	3542600	55684540	115430527	27	11488											
NOX3	50508	broad.mit.edu	37	chr6	155764472	155764472	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgcccagcttggaaagtgCggccagaagtccctgggcct	14	12	0	1	rs142034685		TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr6:155764472C>T	uc003qqm.2	-	5	524	c.421G>A	c.(421-423)GCA>ACA	p.A141T		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	141	Ferric oxidoreductase.|Extracellular (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		TTGGAAAGTGCGGCCAGAAGT	0.577													T	155764472	T	T	155764472	3	4	161	1	0	0	0	0	1	0	0	0	10557	768	27	1	1321	1	NOX3	6	155764472	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	100079932	155764472	15350595	28	11489											
DTX2	113878	broad.mit.edu	37	chr7	76109950	76109950	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgccaccgtctgcagcttcAtcgagcagcagtttgtccag	11	13	2	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr7:76109950A>G	uc003uff.3	+	4	680	c.124A>G	c.(124-126)ATC>GTC	p.I42V	DTX2_uc011kgk.1_Intron|DTX2_uc003ufg.3_Missense_Mutation_p.I42V|DTX2_uc003ufh.3_Missense_Mutation_p.I42V|DTX2_uc003ufj.3_Missense_Mutation_p.I42V	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	42	WWE 1.				Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CTGCAGCTTCATCGAGCAGCA	0.662													G	76109950	G	G	76109950	3	3	161	1	0	0	0	0	1	0	0	0	4794	217	8	4	126	4	DTX2	7	76109950	Missense_Mutation	SNP	A	TCGA-19-4068-01A-01D-1353-08		76109950	83028713	29	11490											
CALCR	799	broad.mit.edu	37	chr7	93067382	93067382	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taattctcaccacaagtgccGccatgacaggtccatggatt	8	12	1	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr7:93067382G>A	uc003umv.1	-	12	1283	c.1022C>T	c.(1021-1023)GCG>GTG	p.A341V	CALCR_uc011kia.1_Missense_Mutation_p.A121V|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.A307V|CALCR_uc003umw.2_Missense_Mutation_p.A307V	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	323	Helical; Name=5; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CACAAGTGCCGCCATGACAGG	0.348													A	93067382	A	A	93067382	3	1	161	1	0	0	0	0	1	0	0	0	2579	1087	38	1	520	1	CALCR	7	93067382	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	16957432	93067382	66071281	30	11491											
LAMB1	3912	broad.mit.edu	37	chr7	107600245	107600245	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctccgttgggatcacacacGgaacttaacgaaccctgagg	10	13	1	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr7:107600245G>A	uc003vew.2	-	19	2684	c.2349C>T	c.(2347-2349)TCC>TCT	p.S783S	LAMB1_uc003vev.2_Silent_p.S807S|LAMB1_uc003vex.2_Silent_p.S783S	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	783	Laminin EGF-like 6.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GATCACACACGGAACTTAACG	0.572													A	107600245	A	A	107600245	2	1	161	1	0	0	0	0	0	0	0	1	8610	1103	39	2		2	LAMB1	7	107600245	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	14532863	107600245	51538418	31	11492											
TRYX3	136541	broad.mit.edu	37	chr7	141955123	141955123	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtaacccccaatatcaccCgaagctttctggaacaatat	5	12	2	0	rs138718517		TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr7:141955123C>T	uc003vxb.2	-	3	508	c.188G>A	c.(187-189)CGG>CAG	p.R63Q	TRYX3_uc003vxc.3_Missense_Mutation_p.R63Q	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	63	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					CAATATCACCCGAAGCTTTCT	0.428													T	141955123	T	T	141955123	3	4	161	1	0	0	0	0	1	0	0	0	16601	652	23	2	549	2	TRYX3	7	141955123	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	34354878	141955123	17183540	32	11493											
ADAMDEC1	27299	broad.mit.edu	37	chr8	24251644	24251644	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cagaggagaggaaattaccaCgaaacctgagaacatggtag	12	7	0	3			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr8:24251644C>G	uc003xdz.2	+	4	567	c.347C>G	c.(346-348)ACG>AGG	p.T116R	ADAMDEC1_uc010lub.2_Missense_Mutation_p.T37R|ADAMDEC1_uc011lab.1_Missense_Mutation_p.T37R	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	116					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		GAAATTACCACGAAACCTGAG	0.463													G	24251644	G	G	24251644	3	3	161	1	0	0	0	0	1	0	0	0	254	536	19	5	361	5	ADAMDEC1	8	24251644	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08		24251644	122112378	33	11494											
FZD3	7976	broad.mit.edu	37	chr8	28385048	28385048	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attttcttcattggatttttGcttgaagatcgagtagcctg	9	6	2	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr8:28385048G>A	uc003xgx.2	+	5	1249	c.771G>A	c.(769-771)TTG>TTA	p.L257L	FZD3_uc010lvb.2_Silent_p.L257L	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	257	Helical; Name=2; (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		TTGGATTTTTGCTTGAAGATC	0.378													A	28385048	A	A	28385048	2	1	161	1	0	0	0	0	0	0	0	1	6131	1310	46	3		3	FZD3	8	28385048	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	4133404	28385048	117978974	34	11495											
GPR124	25960	broad.mit.edu	37	chr8	37693258	37693258	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcctggcaagaggcgtggcGtggccacccccgtcatcttc	14	15	2	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr8:37693258G>A	uc003xkj.2	+	13	2383	c.2020G>A	c.(2020-2022)GTG>ATG	p.V674M	GPR124_uc010lvy.2_Intron	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	674	Extracellular (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GAGGCGTGGCGTGGCCACCCC	0.652													A	37693258	A	A	37693258	3	1	161	1	0	0	0	0	1	0	0	0	6638	1145	40	1	2049	1	GPR124	8	37693258	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	9308210	37693258	108670764	35	11496											
C8orf84	157869	broad.mit.edu	37	chr8	73993342	73993342	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgggcagggcgccccgccGttctgaggctcctgctgcac	16	15	1	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr8:73993342G>A	uc003xzf.2	-	2	526	c.321C>T	c.(319-321)AAC>AAT	p.N107N		NM_153225	NP_694957	Q8IVN8	RPESP_HUMAN	RPE-spondin precursor	107	TSP type-1.				immune response	extracellular region	polysaccharide binding|scavenger receptor activity				0						GCGCCCCGCCGTTCTGAGGCT	0.657													A	73993342	A	A	73993342	2	1	161	1	0	0	0	0	0	0	0	1	2440	1136	40	1		1	C8orf84	8	73993342	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	36300084	73993342	72370680	36	11497											
VPS13B	157680	broad.mit.edu	37	chr8	100874087	100874087	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggatgaggagcactacaacCggcaggaggagtggcggcgg	19	8	0	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr8:100874087C>A	uc003yiv.2	+	58	11314	c.11203C>A	c.(11203-11205)CGG>AGG	p.R3735R	VPS13B_uc003yiw.2_Silent_p.R3710R	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3735					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GCACTACAACCGGCAGGAGGA	0.657													A	100874087	A	A	100874087	2	1	161	1	0	0	0	0	0	0	0	1	17187	643	23	5		5	VPS13B	8	100874087	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	26880745	100874087	45489935	37	11498											
PKHD1L1	93035	broad.mit.edu	37	chr8	110463211	110463211	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cttcctttcataggcacgggAgctgagcaagcctgtgaagt	12	10	1	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr8:110463211A>T	uc003yne.2	+	41	6287	c.6183A>T	c.(6181-6183)GGA>GGT	p.G2061G		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2061	Extracellular (Potential).|IPT/TIG 13.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TAGGCACGGGAGCTGAGCAAG	0.458										HNSCC(38;0.096)	OREG0018931	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	110463211	T	T	110463211	2	4	161	1	0	0	0	0	0	0	0	1	11972	291	11	5		5	PKHD1L1	8	110463211	Silent	SNP	A	TCGA-19-4068-01A-01D-1353-08	9589124	110463211	35900811	38	11499											
FLJ46321	389763	broad.mit.edu	37	chr9	84609453	84609453	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttcagaaaatggatgaagacCtctttgcagtggtttaataa	9	5	2	3			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr9:84609453C>A	uc004amn.2	+	4	4115	c.4068C>A	c.(4066-4068)ACC>ACA	p.T1356T		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1356						integral to membrane					0						GGATGAAGACCTCTTTGCAGT	0.433													A	84609453	A	A	84609453	2	1	161	1	0	0	0	0	0	0	0	1	5932	668	24	5		5	FLJ46321	9	84609453	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08		84609453	56603978	39	11500											
ST6GALNAC6	30815	broad.mit.edu	37	chr9	130653179	130653179	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cggtaggtggtcttgttgccCacatcagctgagtagccagt	13	10	2	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr9:130653179C>A	uc004bso.1	-	5	560	c.441G>T	c.(439-441)GTG>GTT	p.V147V	ST6GALNAC6_uc004bsn.1_Silent_p.V113V|ST6GALNAC6_uc011man.1_Intron|ST6GALNAC6_uc004bsp.1_Silent_p.V147V|ST6GALNAC6_uc004bsq.1_Silent_p.V113V|ST6GALNAC6_uc004bsr.2_Silent_p.V113V|ST6GALNAC6_uc010mxp.1_RNA	NM_013443	NP_038471	Q969X2	SIA7F_HUMAN	sialytransferase 7F	147	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane|plasma membrane					0						TCTTGTTGCCCACATCAGCTG	0.607													A	130653179	A	A	130653179	2	1	161	1	0	0	0	0	0	0	0	1	15227	581	21	5		5	ST6GALNAC6	9	130653179	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	46043726	130653179	10560252	40	11501											
PLXDC2	84898	broad.mit.edu	37	chr10	20453469	20453469	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gactgtccgatgcatttgtcGttgtccacaggatccaacaa	9	11	0	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr10:20453469G>A	uc001iqg.1	+	7	1493	c.856G>A	c.(856-858)GTT>ATT	p.V286I	PLXDC2_uc001iqh.1_Missense_Mutation_p.V237I|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	286	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TGCATTTGTCGTTGTCCACAG	0.443													A	20453469	A	A	20453469	3	1	161	1	0	0	0	0	1	0	0	0	12118	1145	40	1	882	1	PLXDC2	10	20453469	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08		20453469	115081278	41	11502											
MYO3A	53904	broad.mit.edu	37	chr10	26463063	26463063	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actttggaacctacacttagCcaaaggtcaatttatcaaaa	5	9	2	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr10:26463063C>T	uc001isn.2	+	30	4230	c.3870C>T	c.(3868-3870)AGC>AGT	p.S1290S	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1290					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						CTACACTTAGCCAAAGGTCAA	0.428													T	26463063	T	T	26463063	2	4	161	1	0	0	0	0	0	0	0	1	10076	738	26	3		3	MYO3A	10	26463063	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	6009594	26463063	109071684	42	11503											
DKK1	22943	broad.mit.edu	37	chr10	54076434	54076434	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggtcaagtgtgtaccaagcAtaggagaaaaggctctcatg	12	7	2	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr10:54076434A>G	uc001jjr.2	+	4	822	c.668A>G	c.(667-669)CAT>CGT	p.H223R	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	223	DKK-type Cys-2.				negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TGTACCAAGCATAGGAGAAAA	0.463													G	54076434	G	G	54076434	3	3	161	1	0	0	0	0	1	0	0	0	4544	217	8	4	682	4	DKK1	10	54076434	Missense_Mutation	SNP	A	TCGA-19-4068-01A-01D-1353-08	27613371	54076434	81458313	43	11504											
TMEM26	219623	broad.mit.edu	37	chr10	63170245	63170245	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttctgactgacttctcaaCgaagcacggactgccaatgc	8	14	2	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr10:63170245C>T	uc001jlo.2	-	6	1311	c.942G>A	c.(940-942)TCG>TCA	p.S314S	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlp.1_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	314						integral to membrane					0	Prostate(12;0.0112)					GACTTCTCAACGAAGCACGGA	0.557													T	63170245	T	T	63170245	2	4	161	1	0	0	0	0	0	0	0	1	16148	523	19	1		1	TMEM26	10	63170245	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	9093811	63170245	72364502	44	11505											
RUFY2	55680	broad.mit.edu	37	chr10	70154149	70154149	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcacattcaggccaaccagcAgcccaacaattactgctcct	5	16	2	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr10:70154149A>G	uc001job.2	-	5	890	c.563T>C	c.(562-564)CTG>CCG	p.L188P	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Missense_Mutation_p.L119P|RUFY2_uc010qiw.1_Missense_Mutation_p.L95P|RUFY2_uc001jod.1_Missense_Mutation_p.L153P|RUFY2_uc009xpv.1_Missense_Mutation_p.L36P|RUFY2_uc001joe.1_Missense_Mutation_p.L153P	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	202	RUN.					nucleus	metal ion binding			ovary(1)	1						GCCAACCAGCAGCCCAACAAT	0.383													G	70154149	G	G	70154149	3	3	161	1	0	0	0	0	1	0	0	0	13739	188	7	4	1531	4	RUFY2	10	70154149	Missense_Mutation	SNP	A	TCGA-19-4068-01A-01D-1353-08	6983904	70154149	65380598	45	11506											
COL17A1	1308	broad.mit.edu	37	chr10	105815707	105815707	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccccatagggcagtatgctcCtcctgatcctctccagctca	7	17	2	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr10:105815707C>A	uc001kxr.2	-	18	1689	c.1520G>T	c.(1519-1521)AGG>ATG	p.R507M	COL17A1_uc010qqv.1_Missense_Mutation_p.R491M	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	507	Extracellular (Potential).|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CAGTATGCTCCTCCTGATCCT	0.597													A	105815707	A	A	105815707	3	1	161	1	0	0	0	0	1	0	0	0	3674	681	24	5	3129	5	COL17A1	10	105815707	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	35661558	105815707	29719040	46	11507											
UBQLN3	50613	broad.mit.edu	37	chr11	5529360	5529360	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggataagccggggatggcaGccagggaggctcagggattc	18	8	1	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr11:5529360G>A	uc001may.1	-	2	1515	c.1429C>T	c.(1429-1431)CTG>TTG	p.L477L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	477										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGGATGGCAGCCAGGGAGGC	0.552													A	5529360	A	A	5529360	2	1	161	1	0	0	0	0	0	0	0	1	16895	962	34	3		3	UBQLN3	11	5529360	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08		5529360	129477156	47	11508											
DCHS1	8642	broad.mit.edu	37	chr11	6646055	6646055	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccgatcagtggcagagacGgagagaatggcactgcctgg	15	10	1	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr11:6646055G>A	uc001mem.1	-	20	7601	c.7191C>T	c.(7189-7191)TCC>TCT	p.S2397S		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	2397	Cadherin 23.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGCAGAGACGGAGAGAATGG	0.557													A	6646055	A	A	6646055	2	1	161	1	0	0	0	0	0	0	0	1	4287	1103	39	2		2	DCHS1	11	6646055	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	1116695	6646055	128360461	48	11509											
RAG1	5896	broad.mit.edu	37	chr11	36597064	36597064	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactctttgtgatgccacccGtctggaagcctctcaaaatc	7	13	3	1	rs104894286		TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr11:36597064G>A	uc001mwu.3	+	2	2334	c.2210G>A	c.(2209-2211)CGT>CAT	p.R737H	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	737			R -> H (in OS and CHIDG; reduced recombination activity when associated with T-507).		histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GATGCCACCCGTCTGGAAGCC	0.502									Familial_Hemophagocytic_Lymphohistiocytosis				A	36597064	A	A	36597064	3	1	161	1	0	0	0	0	1	0	0	0	13003	1145	40	1	2212	1	RAG1	11	36597064	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	29951009	36597064	98409452	49	11510											
OR5D18	219438	broad.mit.edu	37	chr11	55587399	55587399	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accatttcatttttaggatgCgtagtacaattctttttctt	5	7	3	0	rs147156620	by1000genomes	TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr11:55587399C>T	uc010rin.1	+	1	294	c.294C>T	c.(292-294)TGC>TGT	p.C98C		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TTTTAGGATGCGTAGTACAAT	0.433													T	55587399	T	T	55587399	2	4	161	1	0	0	0	0	0	0	0	1	11157	776	27	1		1	OR5D18	11	55587399	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	18990335	55587399	79419117	50	11511											
OR8J3	81168	broad.mit.edu	37	chr11	55904467	55904467	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgtgactgctatcatatgcGaagcgcaggtggaaaaggct	13	9	1	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr11:55904467G>A	uc010riz.1	-	1	728	c.728C>T	c.(727-729)TCG>TTG	p.S243L		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					TATCATATGCGAAGCGCAGGT	0.403													A	55904467	A	A	55904467	3	1	161	1	0	0	0	0	1	0	0	0	11242	1059	37	2	221	2	OR8J3	11	55904467	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	317068	55904467	79102049	51	11512											
SLC43A3	29015	broad.mit.edu	37	chr11	57193641	57193641	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaggggcaggccctggcccGccatgagcagaagtggagtg	18	11	0	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr11:57193641G>A	uc001nkg.2	-	3	415	c.5C>T	c.(4-6)GCG>GTG	p.A2V	PRG2_uc001nke.2_5'Flank|SLC43A3_uc001nkh.2_Missense_Mutation_p.A2V|SLC43A3_uc010rjr.1_Missense_Mutation_p.A2V|SLC43A3_uc009yme.2_Missense_Mutation_p.A2V|SLC43A3_uc001nki.2_Missense_Mutation_p.A2V|SLC43A3_uc009ymf.1_Missense_Mutation_p.A2V|SLC43A3_uc010rjs.1_Missense_Mutation_p.A2V|SLC43A3_uc009ymg.1_Missense_Mutation_p.A2V	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	2					transmembrane transport	integral to membrane				central_nervous_system(1)	1						GCCCTGGCCCGCCATGAGCAG	0.587													A	57193641	A	A	57193641	3	1	161	1	0	0	0	0	1	0	0	0	14634	1087	38	1	1518	1	SLC43A3	11	57193641	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	1289174	57193641	77812875	52	11513											
DYNC2H1	79659	broad.mit.edu	37	chr11	103006524	103006524	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agagaaatgaagagattcatCggcattccaaatcagtttaa	8	6	2	3			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr11:103006524C>T	uc001pho.2	+	17	2565	c.2421C>T	c.(2419-2421)ATC>ATT	p.I807I	DYNC2H1_uc001phn.1_Silent_p.I807I|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	807	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGAGATTCATCGGCATTCCAA	0.343													T	103006524	T	T	103006524	2	4	161	1	0	0	0	0	0	0	0	1	4846	874	31	2		2	DYNC2H1	11	103006524	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	45812883	103006524	31999992	53	11514											
CD163L1	283316	broad.mit.edu	37	chr12	7519881	7519881	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctcttgaggcaggtctccatCtcatggaataaattctcctc	7	12	4	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr12:7519881C>T	uc001qsy.2	-	18	4256	c.4230G>A	c.(4228-4230)GAG>GAA	p.E1410E	CD163L1_uc010sge.1_Silent_p.E1420E	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1410	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						AGGTCTCCATCTCATGGAATA	0.498													T	7519881	T	T	7519881	2	4	161	1	0	0	0	0	0	0	0	1	2968	912	32	3		3	CD163L1	12	7519881	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08		7519881	126332014	54	11515											
KRT18	3875	broad.mit.edu	37	chr12	53346096	53346096	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgagatcgccacctaccGccgcctgctggaagatggcg	14	14	0	2	rs147541172	byFrequency	TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr12:53346096G>A	uc001sbe.2	+	7	1211	c.1142G>A	c.(1141-1143)CGC>CAC	p.R381H	KRT18_uc009zmn.1_Missense_Mutation_p.R381H|KRT18_uc001sbf.1_Missense_Mutation_p.R208H|KRT18_uc001sbg.2_Missense_Mutation_p.R381H|KRT18_uc009zmo.2_Missense_Mutation_p.R381H|KRT8_uc009zml.1_5'Flank|KRT8_uc009zmm.1_5'Flank	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	381	Interaction with DNAJB6.|Coil 2.|Rod.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						GCCACCTACCGCCGCCTGCTG	0.602													A	53346096	A	A	53346096	3	1	161	1	0	0	0	0	1	0	0	0	8455	1087	38	1	1164	1	KRT18	12	53346096	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	45826215	53346096	80505799	55	11516											
ACACB	32	broad.mit.edu	37	chr12	109693958	109693958	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacagctctgaagggaacGtggcagagcggattctttga	13	9	2	3			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr12:109693958G>A	uc001tob.2	+	45	6299	c.6180G>A	c.(6178-6180)ACG>ACA	p.T2060T	ACACB_uc001toc.2_Silent_p.T2060T|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.T726T	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2060	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TGAAGGGAACGTGGCAGAGCG	0.602													A	109693958	A	A	109693958	2	1	161	1	0	0	0	0	0	0	0	1	107	1132	40	1		1	ACACB	12	109693958	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	56347862	109693958	24157937	56	11517											
PITPNM2	57605	broad.mit.edu	37	chr12	123473301	123473301	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaaaggagaccacgtctgtTgactcccagtagctggcgtg	13	10	1	3			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr12:123473301T>C	uc001uej.1	-	18	2989	c.2850A>G	c.(2848-2850)TCA>TCG	p.S950S	PITPNM2_uc001uek.1_Silent_p.S944S	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	950	DDHD.				metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CCACGTCTGTTGACTCCCAGT	0.632													C	123473301	C	C	123473301	2	2	161	1	0	0	0	0	0	0	0	1	11951	1799	63	4		4	PITPNM2	12	123473301	Silent	SNP	T	TCGA-19-4068-01A-01D-1353-08	13779343	123473301	10378594	57	11518											
MYH6	4624	broad.mit.edu	37	chr14	23861788	23861789	+	Frame_Shift_Del	DEL	TC	-	-													cacctggttttccttcagttTcttctgtagttgaagggcca							TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr14:23861788_23861789delTC	uc001wjv.2	-	25	3391_3392	c.3324_3325delGA	c.(3322-3327)AAGAAAfs	p.K1108fs		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1108_1109	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCCTTCAGTTTCTTCTGTAGTT	0.505													-	23861789	-	-	23861788	7	5	161	1	0	1	0	1	0	0	0	0	10038	1792	62	0	2554	0	MYH6	14	23861788	Frame_Shift_Del	DEL	TC	TCGA-19-4068-01A-01D-1353-08		23861788	83487752	58	11519											
SPTBN5	51332	broad.mit.edu	37	chr15	42160382	42160382	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aggtctgatacacctggtccCgctggtcctgcagggctcga	13	13	1	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr15:42160382C>A	uc001zos.2	-	34	6320	c.5987G>T	c.(5986-5988)CGG>CTG	p.R1996L	hsa-mir-4310|MI0015840_5'Flank	NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2031	Spectrin 16.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CACCTGGTCCCGCTGGTCCTG	0.642													A	42160382	A	A	42160382	3	1	161	1	0	0	0	0	1	0	0	0	15121	652	23	5	5072	5	SPTBN5	15	42160382	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08		42160382	60371010	59	11520											
ATP8B4	79895	broad.mit.edu	37	chr15	50209193	50209193	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaaacacatcattcatgtcGtcagtcagcatgttgcaggc	8	11	4	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr15:50209193G>A	uc001zxu.2	-	20	2221	c.2079C>T	c.(2077-2079)GAC>GAT	p.D693D	ATP8B4_uc010ber.2_Silent_p.D566D|ATP8B4_uc010ufd.1_Silent_p.D503D|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	693	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CATTCATGTCGTCAGTCAGCA	0.333													A	50209193	A	A	50209193	2	1	161	1	0	0	0	0	0	0	0	1	1197	1136	40	1		1	ATP8B4	15	50209193	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	8048811	50209193	52322199	60	11521											
SH3GL3	6457	broad.mit.edu	37	chr15	84257442	84257442	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcatccagtgtccccagaCgagaatacaagccaaggcct	9	14	0	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr15:84257442C>T	uc002bjw.2	+	8	952	c.757C>T	c.(757-759)CGA>TGA	p.R253*	SH3GL3_uc010uot.1_Nonsense_Mutation_p.R253*|SH3GL3_uc002bjx.2_Nonsense_Mutation_p.R184*|SH3GL3_uc002bju.2_Nonsense_Mutation_p.R261*|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	253	Interaction with ARC (By similarity).				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						TGTCCCCAGACGAGAATACAA	0.458													T	84257442	T	T	84257442	4	4	161	1	0	0	0	0	0	1	0	0	14252	528	19	1	787	1	SH3GL3	15	84257442	Nonsense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	34048249	84257442	18273950	61	11522											
DNAH9	1770	broad.mit.edu	37	chr17	11865572	11865572	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggtgcctgctgggacacacAggtaaagcttggaatgaacc	13	9	0	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr17:11865572A>G	uc002gne.2	+	68	13300	c.13232A>G	c.(13231-13233)CAG>CGG	p.Q4411R	DNAH9_uc010coo.2_Missense_Mutation_p.Q3629R|DNAH9_uc002gnf.2_Missense_Mutation_p.Q723R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	4411					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGGGACACACAGGTAAAGCTT	0.473													G	11865572	G	G	11865572	3	3	161	1	0	0	0	0	1	0	0	0	4608	202	7	4	13502	4	DNAH9	17	11865572	Missense_Mutation	SNP	A	TCGA-19-4068-01A-01D-1353-08		11865572	69329638	62	11523											
ALDH3A1	218	broad.mit.edu	37	chr17	19642827	19642827	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcccaccacccaccttgtcGttgctggagaacatgtagag	11	13	0	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr17:19642827G>A	uc010cqu.2	-	7	1440	c.1110C>T	c.(1108-1110)AAC>AAT	p.N370N	ALDH3A1_uc010vzd.1_Silent_p.N370N|ALDH3A1_uc002gwj.2_Silent_p.N370N|ALDH3A1_uc010cqv.2_Silent_p.N369N|ALDH3A1_uc002gwk.2_Silent_p.N487N|ALDH3A1_uc002gwl.1_Silent_p.N297N	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	370					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	CCACCTTGTCGTTGCTGGAGA	0.443													A	19642827	A	A	19642827	2	1	161	1	0	0	0	0	0	0	0	1	497	1136	40	1		1	ALDH3A1	17	19642827	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	7777255	19642827	61552383	63	11524											
DNAI2	64446	broad.mit.edu	37	chr17	72283178	72283178	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatgaagagtatttcaatgaCgaggaggccatggaagtgat	13	4	1	4			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr17:72283178C>T	uc002jkf.2	+	4	507	c.408C>T	c.(406-408)GAC>GAT	p.D136D	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_Intron	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	136					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						ATTTCAATGACGAGGAGGCCA	0.507									Kartagener_syndrome				T	72283178	T	T	72283178	2	4	161	1	0	0	0	0	0	0	0	1	4610	535	19	1		1	DNAI2	17	72283178	Silent	SNP	C	TCGA-19-4068-01A-01D-1353-08	52640351	72283178	8912032	64	11525											
AFG3L2	10939	broad.mit.edu	37	chr18	12356814	12356814	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcttcccagtgcctggaggaCcagtgagaatggcacccttc	11	13	1	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr18:12356814C>G	uc002kqz.1	-	9	1156	c.1043G>C	c.(1042-1044)GGT>GCT	p.G348A		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	348	ATP (Potential).				cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)	GCCTGGAGGACCAGTGAGAAT	0.418													G	12356814	G	G	12356814	3	3	161	1	0	0	0	0	1	0	0	0	360	507	18	5	1386	5	AFG3L2	18	12356814	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08		12356814	65720434	65	11526											
DSG4	147409	broad.mit.edu	37	chr18	28986155	28986155	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttggcacaaatggtgcagttAtatgcctgtgattgcgatga	12	6	0	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr18:28986155A>G	uc002kwq.2	+	12	1887	c.1752A>G	c.(1750-1752)TTA>TTG	p.L584L	DSG4_uc002kwr.2_Silent_p.L584L	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	584	Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGGTGCAGTTATATGCCTGTG	0.483													G	28986155	G	G	28986155	2	3	161	1	0	0	0	0	0	0	0	1	4779	446	16	4		4	DSG4	18	28986155	Silent	SNP	A	TCGA-19-4068-01A-01D-1353-08	16629341	28986155	49091093	66	11527											
THEG	51298	broad.mit.edu	37	chr19	362390	362390	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcacctcccagcgaggatctCggtcaggaacgcacttgtcc	11	15	2	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr19:362390C>T	uc002lol.2	-	8	989	c.950G>A	c.(949-951)CGA>CAA	p.R317Q	THEG_uc002lom.2_Missense_Mutation_p.R293Q	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	317					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGAGGATCTCGGTCAGGAAC	0.577													T	362390	T	T	362390	3	4	161	1	0	0	0	0	1	0	0	0	15854	884	31	2	193	2	THEG	19	362390	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08		362390	58766593	67	11528											
GPX4	2879	broad.mit.edu	37	chr19	1105195	1105195	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccttgcagtgcgcgtcccGggacgactggcgctgtgcgc	16	14	0	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr19:1105195G>A	uc010xgg.1	+	2	202	c.95G>A	c.(94-96)CGG>CAG	p.R32Q	GPX4_uc010xgh.1_Missense_Mutation_p.R32Q|GPX4_uc010xgi.1_Missense_Mutation_p.R69Q	NM_002085	NP_002076	P36969	GPX4_HUMAN	glutathione peroxidase 4 isoform A precursor	32					multicellular organismal development|phospholipid metabolic process		glutathione peroxidase activity|phospholipid-hydroperoxide glutathione peroxidase activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glutathione(DB00143)	TGCGCGTCCCGGGACGACTGG	0.672													A	1105195	A	A	1105195	3	1	161	1	0	0	0	0	1	0	0	0	6742	1116	39	2	300	2	GPX4	19	1105195	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	742805	1105195	58023788	68	11529											
CD209	30835	broad.mit.edu	37	chr19	7808071	7808071	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccattgccactaaattccgCgcagtcttcctccccaacgt	6	17	1	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr19:7808071C>T	uc002mht.2	-	7	1136	c.1069G>A	c.(1069-1071)GCG>ACG	p.A357T	CD209_uc010xju.1_Missense_Mutation_p.A196T|CD209_uc010dvp.2_Missense_Mutation_p.R295H|CD209_uc002mhr.2_Missense_Mutation_p.A333T|CD209_uc002mhs.2_Missense_Mutation_p.A287T|CD209_uc002mhu.2_Missense_Mutation_p.A265T|CD209_uc010dvq.2_Missense_Mutation_p.A351T|CD209_uc002mhq.2_Missense_Mutation_p.A357T|CD209_uc002mhv.2_Missense_Mutation_p.A333T|CD209_uc002mhx.2_Missense_Mutation_p.A313T|CD209_uc002mhw.2_Missense_Mutation_p.A221T|CD209_uc010dvr.2_Missense_Mutation_p.A121T	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	357	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						CTAAATTCCGCGCAGTCTTCC	0.527													T	7808071	T	T	7808071	3	4	161	1	0	0	0	0	1	0	0	0	2984	768	27	1	149	1	CD209	19	7808071	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	6702876	7808071	51320912	69	11530											
MUC16	94025	broad.mit.edu	37	chr19	9072932	9072932	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgattcaaatgctgaaccGgtggtccccacattggtaac	10	10	1	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr19:9072932G>A	uc002mkp.2	-	3	14718	c.14514C>T	c.(14512-14514)ACC>ACT	p.T4838T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4840	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGCTGAACCGGTGGTCCCCA	0.463													A	9072932	A	A	9072932	2	1	161	1	0	0	0	0	0	0	0	1	9973	1103	39	2		2	MUC16	19	9072932	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	1264861	9072932	50056051	70	11531											
ZNF345	25850	broad.mit.edu	37	chr19	37368940	37368940	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	accctatgaatgtaaagaatGtggaaagtcctttagtagtg	10	5	0	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr19:37368940G>C	uc002oex.2	+	3	1586	c.1208G>C	c.(1207-1209)TGT>TCT	p.C403S	ZNF345_uc002oey.3_Missense_Mutation_p.C403S|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	403	C2H2-type 13.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTAAAGAATGTGGAAAGTCC	0.418													C	37368940	C	C	37368940	3	2	161	1	0	0	0	0	1	0	0	0	17856	1377	48	5	1210	5	ZNF345	19	37368940	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	28296008	37368940	21760043	71	11532											
KLC3	147700	broad.mit.edu	37	chr19	45849928	45849929	+	Frame_Shift_Ins	INS	-	G	G													actggaggagacgcagcggcINSggcttcgggccagcgaggag					rs141629020	by1000genomes	TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr19:45849928_45849929insG	uc002pbf.1	+	3	500_501	c.385_386insG	c.(385-387)CGGfs	p.R129fs	KLC3_uc002pbe.2_Frame_Shift_Ins_p.R129fs|KLC3_uc010ejy.1_Frame_Shift_Ins_p.R129fs|KLC3_uc002pbg.1_Frame_Shift_Ins_p.R143fs	NM_177417	NP_803136	Q6P597	KLC3_HUMAN	kinesin light chain 3	129	Potential.					cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GACGCAGCGGCGGCTTCGGGCC	0.713													G	45849929	G	G	45849928	7	5	161	1	0	1	1	0	0	0	0	0	8335	759	27	0	391	0	KLC3	19	45849928	Frame_Shift_Ins	INS	-	TCGA-19-4068-01A-01D-1353-08	8480988	45849928	13279055	72	11533											
KIR3DL1	3811	broad.mit.edu	37	chr19	55341632	55341632	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcacacagagaaaaatcactCgcccttctcagaggcccaag	7	14	3	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr19:55341632C>T	uc002qhk.3	+	9	1300	c.1237C>T	c.(1237-1239)CGC>TGC	p.R413C	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.R338C|KIR3DL1_uc010esf.2_Missense_Mutation_p.R318C|KIR3DL1_uc010yfo.1_Missense_Mutation_p.R355C|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_5'Flank|KIR2DS4_uc002qhm.1_5'Flank	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	413	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		AAAAATCACTCGCCCTTCTCA	0.507													T	55341632	T	T	55341632	3	4	161	1	0	0	0	0	1	0	0	0	8320	884	31	2	1271	2	KIR3DL1	19	55341632	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	9491704	55341632	3787351	73	11534											
TOP1	7150	broad.mit.edu	37	chr20	39726941	39726941	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtatttcaaagcccagacGgaagctcggaaacagatgag	11	9	1	3			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr20:39726941G>A	uc002xjl.2	+	11	1185	c.939G>A	c.(937-939)ACG>ACA	p.T313T		NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	313					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	AAGCCCAGACGGAAGCTCGGA	0.368			T	NUP98	AML*								A	39726941	A	A	39726941	2	1	161	1	0	0	0	0	0	0	0	1	16360	1103	39	2		2	TOP1	20	39726941	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08		39726941	23298579	74	11535											
SLC12A5	57468	broad.mit.edu	37	chr20	44665416	44665416	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctccatgagtgcaattgcaAcgaatggtgttgtgcctggt	12	8	1	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr20:44665416A>G	uc010zxl.1	+	5	608	c.532A>G	c.(532-534)ACG>GCG	p.T178A	SLC12A5_uc002xra.2_Missense_Mutation_p.T155A|SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.T155A	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	178	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGCAATTGCAACGAATGGTGT	0.612													G	44665416	G	G	44665416	3	3	161	1	0	0	0	0	1	0	0	0	14386	43	2	4	606	4	SLC12A5	20	44665416	Missense_Mutation	SNP	A	TCGA-19-4068-01A-01D-1353-08	4938475	44665416	18360104	75	11536											
TFF2	7032	broad.mit.edu	37	chr21	43767708	43767708	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccgggtagccacagtttcttCggtctgagacctccatgacg	11	13	2	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr21:43767708C>T	uc002zaw.2	-	3	405	c.263G>A	c.(262-264)CGA>CAA	p.R88Q		NM_005423	NP_005414	Q03403	TFF2_HUMAN	trefoil factor 2 precursor	88	P-type 2.				digestion	extracellular region				pancreas(1)	1						ACAGTTTCTTCGGTCTGAGAC	0.602													T	43767708	T	T	43767708	3	4	161	1	0	0	0	0	1	0	0	0	15801	884	31	2	134	2	TFF2	21	43767708	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08		43767708	4362187	76	11537											
KRTAP10-2	386679	broad.mit.edu	37	chr21	45970888	45970888	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgactcagagcaggtgggcaCgcagcacacagctttgcagc	13	12	1	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr21:45970888C>T	uc002zfi.1	-	1	501	c.454G>A	c.(454-456)GTG>ATG	p.V152M	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	152	13.|22 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)	1						CAGGTGGGCACGCAGCACACA	0.617													T	45970888	T	T	45970888	3	4	161	1	0	0	0	0	1	0	0	0	8509	536	19	1	317	1	KRTAP10-2	21	45970888	Missense_Mutation	SNP	C	TCGA-19-4068-01A-01D-1353-08	2203180	45970888	2159007	77	11538											
KRTAP10-7	386675	broad.mit.edu	37	chr21	46021573	46021573	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgccgcccagcctcctgtgTgtctctcctttgccgccccg	9	20	1	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr21:46021573T>G	uc002zfn.3	+	2	1062	c.1037T>G	c.(1036-1038)GTG>GGG	p.V346G	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198689	NP_941962	P60409	KR107_HUMAN	keratin associated protein 10-7	351	30 X 5 AA repeats of C-C-X(3).					keratin filament					0						GCCTCCTGTGTGTCTCTCCTT	0.672													G	46021573	G	G	46021573	3	3	161	1	0	0	0	0	1	0	0	0	8514	1696	59	5	1043	5	KRTAP10-7	21	46021573	Missense_Mutation	SNP	T	TCGA-19-4068-01A-01D-1353-08	50685	46021573	2108322	78	11539											
CDC42EP1	11135	broad.mit.edu	37	chr22	37964570	37964570	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaagtccagcccagtgggaGggggtccccgaggacctgct	16	12	0	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chr22:37964570G>A	uc003asz.3	+	3	1322	c.919G>A	c.(919-921)GGG>AGG	p.G307R		NM_152243	NP_689449	Q00587	BORG5_HUMAN	CDC42 effector protein 1	307					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding				0	Melanoma(58;0.0574)					CCCAGTGGGAGGGGGTCCCCG	0.692													A	37964570	A	A	37964570	3	1	161	1	0	0	0	0	1	0	0	0	3075	1000	35	3	925	3	CDC42EP1	22	37964570	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08		37964570	13339996	79	11540											
ZMYM3	9203	broad.mit.edu	37	chrX	70466243	70466243	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttcatctccaccttgcaggaGacgccccgattctgcatcag	8	15	4	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chrX:70466243G>T	uc004dzh.1	-	15	2619	c.2532C>A	c.(2530-2532)GTC>GTA	p.V844V	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.V844V|ZMYM3_uc004dzj.1_Silent_p.V832V	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	844					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CCTTGCAGGAGACGCCCCGAT	0.597													T	70466243	T	T	70466243	2	4	161	1	0	0	0	0	0	0	0	1	17698	929	33	5		5	ZMYM3	23	70466243	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08		70466243	84804317	80	11541											
ERCC6L	54821	broad.mit.edu	37	chrX	71428507	71428507	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aaagtttaaatgcttcttccAggtctccattcttagttgct	6	9	3	0			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chrX:71428507A>T	uc004eaq.1	-	2	207	c.110T>A	c.(109-111)CTG>CAG	p.L37Q	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_5'UTR	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	37	TPR 1.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					TGCTTCTTCCAGGTCTCCATT	0.363													T	71428507	T	T	71428507	3	4	161	1	0	0	0	0	1	0	0	0	5218	188	7	5	3646	5	ERCC6L	23	71428507	Missense_Mutation	SNP	A	TCGA-19-4068-01A-01D-1353-08	962264	71428507	83842053	81	11542											
SLC6A14	11254	broad.mit.edu	37	chrX	115590033	115590033	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccatacctggaacaacatcGtggggaaagatataaagaca	9	8	0	2			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chrX:115590033G>A	uc004eqi.2	+	14	1945	c.1841G>A	c.(1840-1842)CGT>CAT	p.R614H		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	614	Cytoplasmic (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	GAACAACATCGTGGGGAAAGA	0.403													A	115590033	A	A	115590033	3	1	161	1	0	0	0	0	1	0	0	0	14677	1145	40	1	1895	1	SLC6A14	23	115590033	Missense_Mutation	SNP	G	TCGA-19-4068-01A-01D-1353-08	44161526	115590033	39680527	82	11543											
ZNF280C	55609	broad.mit.edu	37	chrX	129339341	129339341	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttagccatacgatctaagccGgaagaatcagctaggaaatc	9	9	2	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chrX:129339341G>A	uc004evm.2	-	17	2245	c.2091C>T	c.(2089-2091)TCC>TCT	p.S697S		NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	697					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						GATCTAAGCCGGAAGAATCAG	0.323													A	129339341	A	A	129339341	2	1	161	1	0	0	0	0	0	0	0	1	17813	1103	39	2		2	ZNF280C	23	129339341	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	13749308	129339341	25931219	83	11544											
F9	2158	broad.mit.edu	37	chrX	138643870	138643870	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attgctgacaaggaatacacGaacatcttcctcaaatttgg	7	9	2	1			TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chrX:138643870G>A	uc004fas.1	+	8	1055	c.1026G>A	c.(1024-1026)ACG>ACA	p.T342T	F9_uc004fat.1_Silent_p.T304T	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	342	Peptidase S1.		T -> K (in HEMB; mild).|T -> M (in HEMB; moderate).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	AGGAATACACGAACATCTTCC	0.433													A	138643870	A	A	138643870	2	1	161	1	0	0	0	0	0	0	0	1	5351	1045	37	2		2	F9	23	138643870	Silent	SNP	G	TCGA-19-4068-01A-01D-1353-08	9304529	138643870	16626690	84	11545											
F8	2157	broad.mit.edu	37	chrX	154194774	154194774	+	Frame_Shift_Del	DEL	T	-	-													agcaatgtaatgtacccaagTtttaggatgcttcttggcaa							TCGA-19-4068-01A-01D-1353-08	TCGA-19-4068-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0dcd7c56-8322-4598-9a89-89194700fd3c	624f5c85-5108-422b-be38-42b6c5976c02	g.chrX:154194774delT	uc004fmt.2	-	8	1369	c.1198delA	c.(1198-1200)ACTfs	p.T400fs		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	400	F5/8 type A 2.|Plastocyanin-like 3.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TGTACCCAAGTTTTAGGATGC	0.448													-	154194774	-	-	154194774	7	5	161	1	0	1	0	1	0	0	0	0	5350	1725	60	0	5961	0	F8	23	154194774	Frame_Shift_Del	DEL	T	TCGA-19-4068-01A-01D-1353-08	15550904	154194774	1075786	85	11546											
RERE	473	broad.mit.edu	37	chr1	8424241	8424242	+	Frame_Shift_Ins	INS	-	T	T													atgggcgggagctcaccgtaINStttcttgaagtggatgcgac							TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr1:8424241_8424242insT	uc001ape.2	-	16	2424_2425	c.1614_1615insA	c.(1612-1617)AAATACfs	p.K538fs	RERE_uc001apf.2_Frame_Shift_Ins_p.K538fs|RERE_uc010nzx.1_Frame_Shift_Ins_p.K270fs|RERE_uc001apd.2_5'UTR	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	538_539					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AGCTCACCGTATTTCTTGAAGT	0.569													T	8424242	T	T	8424241	7	5	162	1	0	1	1	0	0	0	0	0	13231	449	16	0	3121	0	RERE	1	8424241	Frame_Shift_Ins	INS	-	TCGA-19-5947-01A-11D-1696-08		8424241	240826380	1	11547											
MSH4	4438	broad.mit.edu	37	chr1	76288094	76288094	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	catttcttgtgttttgaaagGaataatcacactctctttgg	7	7	3	1			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr1:76288094G>A	uc001dhd.1	+	7	1031	c.990G>A	c.(988-990)AGG>AGA	p.R330R		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	330					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						GTTTTGAAAGGAATAATCACA	0.308								MMR					A	76288094	A	A	76288094	2	1	162	1	0	0	0	0	0	0	0	1	9872	1188	41	3		3	MSH4	1	76288094	Silent	SNP	G	TCGA-19-5947-01A-11D-1696-08	67863853	76288094	172962527	2	11548											
RPL5	6125	broad.mit.edu	37	chr1	93303161	93303161	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acaagaaacagttctctcaaTacataaagaacagcgtaact	5	9	2	2			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr1:93303161T>C	uc001doz.2	+	6	754	c.676T>C	c.(676-678)TAC>CAC	p.Y226H	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_RNA|RPL5_uc001dpb.2_Missense_Mutation_p.Y176H|RPL5_uc001dpd.2_Missense_Mutation_p.Y27H	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5	226					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		GTTCTCTCAATACATAAAGAA	0.368													C	93303161	C	C	93303161	3	2	162	1	0	0	0	0	1	0	0	0	13597	1406	49	4	698	4	RPL5	1	93303161	Missense_Mutation	SNP	T	TCGA-19-5947-01A-11D-1696-08	17015067	93303161	155947460	3	11549											
SCYL3	57147	broad.mit.edu	37	chr1	169833511	169833511	+	Frame_Shift_Del	DEL	T	-	-													actttgaaaaagcattcaccTtttttggggccaagcagata							TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr1:169833511delT	uc001ggs.2	-	9	1152	c.954delA	c.(952-954)AAAfs	p.K318fs	SCYL3_uc010plw.1_5'UTR|SCYL3_uc001ggt.2_Frame_Shift_Del_p.K318fs|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	318	HEAT 2.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGCATTCACCTTTTTTGGGGC	0.393													-	169833511	-	-	169833511	7	5	162	1	0	1	0	1	0	0	0	0	13949	1623	56	0	1298	0	SCYL3	1	169833511	Frame_Shift_Del	DEL	T	TCGA-19-5947-01A-11D-1696-08	76530350	169833511	79417110	4	11550											
GALNT14	79623	broad.mit.edu	37	chr2	31360949	31360949	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccgacgagtcaggcgccGcatggtcccctttgccgctt	12	16	1	0			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr2:31360949G>A	uc002rnr.2	-	1	623	c.4C>T	c.(4-6)CGG>TGG	p.R2W	GALNT14_uc002rns.2_Missense_Mutation_p.R2W|GALNT14_uc010ymr.1_5'UTR|GALNT14_uc010ezo.1_Missense_Mutation_p.R2W|GALNT14_uc010ezp.1_Intron	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	2	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GTCAGGCGCCGCATGGTCCCC	0.682													A	31360949	A	A	31360949	3	1	162	1	0	0	0	0	1	0	0	0	6212	1086	38	1	1714	1	GALNT14	2	31360949	Missense_Mutation	SNP	G	TCGA-19-5947-01A-11D-1696-08		31360949	211838424	5	11551											
ZAK	51776	broad.mit.edu	37	chr2	174104210	174104210	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggttttcacttgaaaccaGgaactggcccacaggtaaat	9	9	1	1			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr2:174104210G>A	uc002uhz.2	+	16	1545	c.1345G>A	c.(1345-1347)GGA>AGA	p.G449R	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	449					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			CTTGAAACCAGGAACTGGCCC	0.398													A	174104210	A	A	174104210	3	1	162	1	0	0	0	0	1	0	0	0	17509	1001	35	3	1788	3	ZAK	2	174104210	Missense_Mutation	SNP	G	TCGA-19-5947-01A-11D-1696-08	142743261	174104210	69095163	6	11552											
LMCD1	29995	broad.mit.edu	37	chr3	8574487	8574487	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gggatgcaaggggacgtgttCgggcttcgagccacattcat	15	9	1	0			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr3:8574487C>T	uc003bqq.2	+	2	221	c.107C>T	c.(106-108)TCG>TTG	p.S36L	LMCD1_uc011atd.1_Intron|LMCD1_uc011ate.1_Silent_p.F9F	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	36	Cys-rich.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		GGGACGTGTTCGGGCTTCGAG	0.537													T	8574487	T	T	8574487	3	4	162	1	0	0	0	0	1	0	0	0	8844	893	31	2	113	2	LMCD1	3	8574487	Missense_Mutation	SNP	C	TCGA-19-5947-01A-11D-1696-08		8574487	189447943	7	11553											
TLR9	54106	broad.mit.edu	37	chr3	52257538	52257538	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtgacgagggcactccatgCaggggttgggagcgtggtcg	19	8	0	1			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr3:52257538C>A	uc003dda.1	-	2	1428	c.794G>T	c.(793-795)TGC>TTC	p.C265F	TLR9_uc003ddb.2_Missense_Mutation_p.C362F	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	265	LRR 8.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GCACTCCATGCAGGGGTTGGG	0.617													A	52257538	A	A	52257538	3	1	162	1	0	0	0	0	1	0	0	0	15955	710	25	5	2308	5	TLR9	3	52257538	Missense_Mutation	SNP	C	TCGA-19-5947-01A-11D-1696-08	43683051	52257538	145764892	8	11554											
SR140	23350	broad.mit.edu	37	chr3	142773820	142773820	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacatcccccagcccatctcGcagtagcagtggtagacgag	10	14	1	1			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr3:142773820G>A	uc003evh.1	+	27	2909	c.2810G>A	c.(2809-2811)CGC>CAC	p.R937H	SR140_uc003evi.1_Missense_Mutation_p.R528H|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.R936H	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	937	Arg/Ser-rich.				RNA processing	nucleus	nucleotide binding|RNA binding				0						AGCCCATCTCGCAGTAGCAGT	0.478													A	142773820	A	A	142773820	3	1	162	1	0	0	0	0	1	0	0	0	15130	1087	38	1	2916	1	SR140	3	142773820	Missense_Mutation	SNP	G	TCGA-19-5947-01A-11D-1696-08	90516282	142773820	55248610	9	11555											
PIK3CA	5290	broad.mit.edu	37	chr3	178921548	178921548	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaattctttgtgcaacctacGtgaatgtaaatattcgagac	7	7	1	2			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr3:178921548G>A	uc003fjk.2	+	5	1187	c.1030G>A	c.(1030-1032)GTG>ATG	p.V344M		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	344					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.V344A(1)|p.V344G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGCAACCTACGTGAATGTAAA	0.308		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178921548	A	A	178921548	3	1	162	1	0	0	0	0	1	0	0	0	11913	1145	40	1	1044	1	PIK3CA	3	178921548	Missense_Mutation	SNP	G	TCGA-19-5947-01A-11D-1696-08	36147728	178921548	19100882	10	11556											
PIK3R1	5295	broad.mit.edu	37	chr5	67591152	67591152	+	Frame_Shift_Del	DEL	T	-	-													gacgagagaccaatacttgaTgtaagtatttgaaatggaat							TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr5:67591152delT	uc003jva.2	+	13	2305	c.1745delT	c.(1744-1746)ATGfs	p.M582fs	PIK3R1_uc003jvb.2_Frame_Shift_Del_p.M582fs|PIK3R1_uc003jvc.2_Frame_Shift_Del_p.M282fs|PIK3R1_uc003jvd.2_Frame_Shift_Del_p.M312fs|PIK3R1_uc003jve.2_Frame_Shift_Del_p.M261fs|PIK3R1_uc011crb.1_Frame_Shift_Del_p.M252fs	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	582					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.M582_D605>I(4)|p.R577_M582>K(1)|p.Y580fs*1(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CAATACTTGATGTAAGTATTT	0.373			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67591152	-	-	67591152	7	5	162	1	0	1	0	1	0	0	0	0	11918	1478	51	0	1921	0	PIK3R1	5	67591152	Frame_Shift_Del	DEL	T	TCGA-19-5947-01A-11D-1696-08		67591152	113324108	11	11557											
AFF4	27125	broad.mit.edu	37	chr5	132227876	132227877	+	Frame_Shift_Ins	INS	-	G	G													ttaacctccttggagctactINSggaagtcttcccttcggtct							TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr5:132227876_132227877insG	uc003kyd.2	-	13	3024_3025	c.2616_2617insC	c.(2614-2619)TCCAGTfs	p.S872fs	AFF4_uc011cxk.1_Frame_Shift_Ins_p.S550fs|AFF4_uc003kye.1_Frame_Shift_Ins_p.S872fs	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	872_873	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGGAGCTACTGGAAGTCTTCC	0.47													G	132227877	G	G	132227876	7	5	162	1	0	1	1	0	0	0	0	0	359	1580	55	0	910	0	AFF4	5	132227876	Frame_Shift_Ins	INS	-	TCGA-19-5947-01A-11D-1696-08	64636724	132227876	48687384	12	11558											
PCDHA6	56142	broad.mit.edu	37	chr5	140209539	140209539	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaagcagcgctcgcttcccGtttcgcgtggggctgtacac	13	14	0	0			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr5:140209539G>A	uc003lho.2	+	1	1890	c.1863G>A	c.(1861-1863)CCG>CCA	p.P621P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.P621P	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	621	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCGCTTCCCGTTTCGCGTGG	0.657													A	140209539	A	A	140209539	2	1	162	1	0	0	0	0	0	0	0	1	11528	1132	40	1		1	PCDHA6	5	140209539	Silent	SNP	G	TCGA-19-5947-01A-11D-1696-08	7981663	140209539	40705721	13	11559											
SH3RF2	153769	broad.mit.edu	37	chr5	145439569	145439569	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccctcctccccctcagccGtggtggtggagatggggtcc	13	16	1	1			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr5:145439569G>A	uc003lnt.2	+	9	1934	c.1696G>A	c.(1696-1698)GTG>ATG	p.V566M	SH3RF2_uc011dbl.1_Missense_Mutation_p.V566M|SH3RF2_uc011dbm.1_Missense_Mutation_p.V51M|SH3RF2_uc003lnu.2_Missense_Mutation_p.V57M|SH3RF2_uc011dbn.1_Missense_Mutation_p.V57M|SH3RF2_uc011dbo.1_Missense_Mutation_p.V23M	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	566							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCCTCAGCCGTGGTGGTGGA	0.672													A	145439569	A	A	145439569	3	1	162	1	0	0	0	0	1	0	0	0	14259	1145	40	1	1726	1	SH3RF2	5	145439569	Missense_Mutation	SNP	G	TCGA-19-5947-01A-11D-1696-08	5230030	145439569	35475691	14	11560											
RIMS1	22999	broad.mit.edu	37	chr6	72957754	72957754	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atctcagaagatggaaaggcCttccatttctgttatttctc	7	9	3	2			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr6:72957754C>A	uc003pga.2	+	12	2242	c.2165C>A	c.(2164-2166)CCT>CAT	p.P722H	RIMS1_uc011dyb.1_Missense_Mutation_p.P348H|RIMS1_uc003pgc.2_Missense_Mutation_p.P348H|RIMS1_uc010kaq.2_Missense_Mutation_p.P196H|RIMS1_uc011dyc.1_Missense_Mutation_p.P196H|RIMS1_uc010kar.2_Missense_Mutation_p.P115H|RIMS1_uc011dyd.1_Missense_Mutation_p.P181H|RIMS1_uc003pgf.2_5'Flank|RIMS1_uc003pgg.2_5'Flank|RIMS1_uc003pgi.2_5'Flank|RIMS1_uc003pgh.2_5'Flank|RIMS1_uc003pgd.2_5'Flank|RIMS1_uc003pge.2_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.P348H|RIMS1_uc010kas.1_Missense_Mutation_p.P181H	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	722					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ATGGAAAGGCCTTCCATTTCT	0.333													A	72957754	A	A	72957754	3	1	162	1	0	0	0	0	1	0	0	0	13367	681	24	5	2374	5	RIMS1	6	72957754	Missense_Mutation	SNP	C	TCGA-19-5947-01A-11D-1696-08		72957754	98157313	15	11561											
DENND2A	27147	broad.mit.edu	37	chr7	140301861	140301861	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccccgacgttcactgctcCtttattcctctccttctctg	4	18	3	0			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr7:140301861C>T	uc010lnj.2	-	1	482	c.337G>A	c.(337-339)GGA>AGA	p.G113R	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.G113R|DENND2A_uc003vvw.2_Missense_Mutation_p.G113R|DENND2A_uc003vvx.2_Missense_Mutation_p.G113R	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	113										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					TTCACTGCTCCTTTATTCCTC	0.587													T	140301861	T	T	140301861	3	4	162	1	0	0	0	0	1	0	0	0	4429	690	24	3	2764	3	DENND2A	7	140301861	Missense_Mutation	SNP	C	TCGA-19-5947-01A-11D-1696-08		140301861	18836802	16	11562											
RAG2	5897	broad.mit.edu	37	chr11	36615451	36615451	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ccctccatggatgatgtattGatgcttttcagactccaagc	8	11	1	3	rs149769148		TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr11:36615451G>C	uc001mwv.3	-	2	456	c.268C>G	c.(268-270)CAA>GAA	p.Q90E	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	90					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				ATGATGTATTGATGCTTTTCA	0.413									Familial_Hemophagocytic_Lymphohistiocytosis				C	36615451	C	C	36615451	3	2	162	1	0	0	0	0	1	0	0	0	13005	1299	45	5	1319	5	RAG2	11	36615451	Missense_Mutation	SNP	G	TCGA-19-5947-01A-11D-1696-08		36615451	98391065	17	11563											
KDELC2	143888	broad.mit.edu	37	chr11	108361783	108361783	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcgacagtttcatacatcCtatatctcatcaaaaatgtt	3	10	3	0			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr11:108361783C>T	uc001pkj.2	-	2	380	c.314G>A	c.(313-315)AGG>AAG	p.R105K	KDELC2_uc001pki.2_Missense_Mutation_p.R49K	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	105	Filamin.					endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		TTCATACATCCTATATCTCAT	0.388													T	108361783	T	T	108361783	3	4	162	1	0	0	0	0	1	0	0	0	8118	681	24	3	1237	3	KDELC2	11	108361783	Missense_Mutation	SNP	C	TCGA-19-5947-01A-11D-1696-08	71746332	108361783	26644733	18	11564											
ESAM	90952	broad.mit.edu	37	chr11	124623728	124623728	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcgtgggggtcaatgcAccaggcctgggagggccatg	19	10	1	0			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr11:124623728A>C	uc001qav.3	-	7	1160	c.987T>G	c.(985-987)GGT>GGG	p.G329G	VSIG2_uc001qas.2_5'Flank|VSIG2_uc001qat.2_5'Flank|ESAM_uc010sao.1_Intron|ESAM_uc001qau.3_Silent_p.G256G|ESAM_uc001qaw.3_RNA|ESAM_uc001qax.3_RNA|ESAM_uc009zbi.2_Missense_Mutation_p.V328G	NM_138961	NP_620411	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule precursor	329	Cytoplasmic (Potential).				blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction					0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		GGGTCAATGCACCAGGCCTGG	0.647													C	124623728	C	C	124623728	2	2	162	1	0	0	0	0	0	0	0	1	5247	146	6	5		5	ESAM	11	124623728	Silent	SNP	A	TCGA-19-5947-01A-11D-1696-08	16261945	124623728	10382788	19	11565											
ANKRD33	341405	broad.mit.edu	37	chr12	52284586	52284586	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgccccttcactcctagaaCggctgcaggctaccttgagc	9	15	1	2			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr12:52284586C>T	uc001rzf.3	+	5	1060	c.481C>T	c.(481-483)CGG>TGG	p.R161W	ANKRD33_uc001rzh.3_3'UTR|ANKRD33_uc001rzd.2_Missense_Mutation_p.R286W|ANKRD33_uc001rze.2_Missense_Mutation_p.R182W|ANKRD33_uc001rzg.3_Missense_Mutation_p.R88W|ANKRD33_uc001rzi.3_Missense_Mutation_p.R161W	NM_001130015	NP_001123487	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33 isoform 1	161											0				BRCA - Breast invasive adenocarcinoma(357;0.0969)		ACTCCTAGAACGGCTGCAGGC	0.552													T	52284586	T	T	52284586	3	4	162	1	0	0	0	0	1	0	0	0	661	527	19	1	904	1	ANKRD33	12	52284586	Missense_Mutation	SNP	C	TCGA-19-5947-01A-11D-1696-08		52284586	81567309	20	11566											
IGDCC3	9543	broad.mit.edu	37	chr15	65621380	65621380	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cggcgcagggagccgtggccTctgtggtcttcgcctccgtc	15	15	2	0			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr15:65621380T>A	uc002aos.2	-	14	2564	c.2312A>T	c.(2311-2313)GAG>GTG	p.E771V	IGDCC3_uc002aor.1_Missense_Mutation_p.E57V	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	771	Cytoplasmic (Potential).									ovary(3)	3						AGCCGTGGCCTCTGTGGTCTT	0.716													A	65621380	A	A	65621380	3	1	162	1	0	0	0	0	1	0	0	0	7568	1551	54	5	136	5	IGDCC3	15	65621380	Missense_Mutation	SNP	T	TCGA-19-5947-01A-11D-1696-08		65621380	36910012	21	11567											
RBBP6	5930	broad.mit.edu	37	chr16	24581255	24581256	+	Frame_Shift_Ins	INS	-	A	A													atcttcctctcagaaggatgINSaaaaaatcactggaaccccc							TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr16:24581255_24581256insA	uc002dmh.2	+	17	4284_4285	c.3244_3245insA	c.(3244-3246)GAAfs	p.E1082fs	RBBP6_uc010vcb.1_Frame_Shift_Ins_p.E949fs|RBBP6_uc002dmi.2_Frame_Shift_Ins_p.E1048fs|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Frame_Shift_Ins_p.E915fs	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1082	Interaction with RB1 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TCAGAAGGATGAAAAAATCACT	0.406													A	24581256	A	A	24581255	7	5	162	1	0	1	1	0	0	0	0	0	13103	1291	45	0	3364	0	RBBP6	16	24581255	Frame_Shift_Ins	INS	-	TCGA-19-5947-01A-11D-1696-08		24581255	65773498	22	11568											
CES3	23491	broad.mit.edu	37	chr16	66997813	66997813	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgtggttacagtccagtacCgccttggggtccttggcttc	12	12	0	0	rs148620443	byFrequency	TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr16:66997813C>T	uc002eqt.2	+	4	608	c.535C>T	c.(535-537)CGC>TGC	p.R179C	CES3_uc010cdz.2_Missense_Mutation_p.R179C|CES3_uc010cea.2_RNA	NM_024922	NP_079198	Q6UWW8	EST3_HUMAN	carboxylesterase 3 precursor	179						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			ovary(3)|central_nervous_system(2)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		AGTCCAGTACCGCCTTGGGGT	0.607													T	66997813	T	T	66997813	3	4	162	1	0	0	0	0	1	0	0	0	3271	652	23	2	549	2	CES3	16	66997813	Missense_Mutation	SNP	C	TCGA-19-5947-01A-11D-1696-08	42416558	66997813	23356940	23	11569											
SSTR2	6752	broad.mit.edu	37	chr17	71166297	71166297	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catattcaacgtttcttccgTctccatggccatcagcccca	5	16	4	0			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr17:71166297T>C	uc002jje.2	+	2	1199	c.839T>C	c.(838-840)GTC>GCC	p.V280A		NM_001050	NP_001041	P30874	SSR2_HUMAN	somatostatin receptor 2	280	Extracellular (Potential).				digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity				0			LUSC - Lung squamous cell carcinoma(166;0.197)			GTTTCTTCCGTCTCCATGGCC	0.512													C	71166297	C	C	71166297	3	2	162	1	0	0	0	0	1	0	0	0	15197	1667	58	4	841	4	SSTR2	17	71166297	Missense_Mutation	SNP	T	TCGA-19-5947-01A-11D-1696-08		71166297	10028913	24	11570											
CDH19	28513	broad.mit.edu	37	chr18	64178924	64178925	+	Splice_Site	INS	-	A	A													actgatagtctgaattacctINSaaaaaaaaagggggatagat							TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr18:64178924_64178925insA	uc002lkc.1	-	10	1597	c.1459_splice	c.e10-1	p.V487_splice	CDH19_uc010dql.1_Splice_Site|CDH19_uc010xey.1_Intron	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CTGAATTACCTAAAAAAAAAGG	0.317													A	64178925	A	A	64178924	8	5	162	1	0	1	1	0	0	0	1	0	3104	1536	53	0	873	0	CDH19	18	64178924	Splice_Site	INS	-	TCGA-19-5947-01A-11D-1696-08		64178924	13898324	25	11571											
ZNF516	9658	broad.mit.edu	37	chr18	74091275	74091275	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgggcgatgacggtgggcGtaggggtggcgctcctgctg	20	11	0	1			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr18:74091275G>A	uc010dqx.1	-	3	3030	c.2795C>T	c.(2794-2796)ACG>ATG	p.T932M	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	932					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GACGGTGGGCGTAGGGGTGGC	0.726													A	74091275	A	A	74091275	3	1	162	1	0	0	0	0	1	0	0	0	17957	1145	40	1	713	1	ZNF516	18	74091275	Missense_Mutation	SNP	G	TCGA-19-5947-01A-11D-1696-08	9912351	74091275	3985973	26	11572											
ZNF135	7694	broad.mit.edu	37	chr19	58578313	58578313	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccttcacgcctgtgaagaCgcctgttctggagcagtggc	14	12	2	2			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr19:58578313C>T	uc010yhq.1	+	5	593	c.497C>T	c.(496-498)ACG>ATG	p.T166M	ZNF135_uc002qre.2_Missense_Mutation_p.T154M|ZNF135_uc002qrd.1_Missense_Mutation_p.T112M|ZNF135_uc002qrf.2_Missense_Mutation_p.T112M|ZNF135_uc002qrg.2_Missense_Mutation_p.T124M|ZNF135_uc010yhr.1_Translation_Start_Site	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	166					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CCTGTGAAGACGCCTGTTCTG	0.557													T	58578313	T	T	58578313	3	4	162	1	0	0	0	0	1	0	0	0	17722	536	19	1	664	1	ZNF135	19	58578313	Missense_Mutation	SNP	C	TCGA-19-5947-01A-11D-1696-08		58578313	550670	27	11573											
SEMG2	6407	broad.mit.edu	37	chr20	43851147	43851147	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatatcatacccgtcttcaCgtacagaagaaagacaactt	5	10	3	3	rs140069155		TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chr20:43851147C>T	uc010ggz.2	+	2	931	c.874C>T	c.(874-876)CGT>TGT	p.R292C	SEMG2_uc002xnk.2_Missense_Mutation_p.R292C|SEMG2_uc002xnl.2_Missense_Mutation_p.R292C	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	292	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CCCGTCTTCACGTACAGAAGA	0.393													T	43851147	T	T	43851147	3	4	162	1	0	0	0	0	1	0	0	0	14045	536	19	1	880	1	SEMG2	20	43851147	Missense_Mutation	SNP	C	TCGA-19-5947-01A-11D-1696-08		43851147	19174373	28	11574											
CXorf66	347487	broad.mit.edu	37	chrX	139038184	139038184	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcattcacatgatcaccgtaTgcattgttcctggaatctaa	6	10	4	1			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chrX:139038184T>C	uc004fbb.2	-	3	979	c.957A>G	c.(955-957)GCA>GCG	p.A319A		NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor	319	Cytoplasmic (Potential).					integral to membrane					0						GATCACCGTATGCATTGTTCC	0.383													C	139038184	C	C	139038184	2	2	162	1	0	0	0	0	0	0	0	1	4118	1451	51	4		4	CXorf66	23	139038184	Silent	SNP	T	TCGA-19-5947-01A-11D-1696-08		139038184	16232376	29	11575											
UBE2NL	389898	broad.mit.edu	37	chrX	142967295	142967295	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagaaccagatgaaagcaaCgcccgttattttcatgtggt	10	9	1	3			TCGA-19-5947-01A-11D-1696-08	TCGA-19-5947-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	d5e7dd90-ead0-40fe-94c5-bc740cb509ab	fa48fd89-0ab3-4670-9276-3257e1451d5d	g.chrX:142967295C>T	uc004fca.2	+	1	123	c.93C>T	c.(91-93)AAC>AAT	p.N31N		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	31							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					ATGAAAGCAACGCCCGTTATT	0.493													T	142967295	T	T	142967295	2	4	162	1	0	0	0	0	0	0	0	1	16864	535	19	1		1	UBE2NL	23	142967295	Silent	SNP	C	TCGA-19-5947-01A-11D-1696-08	3929111	142967295	12303265	30	11576											
EPHA8	2046	broad.mit.edu	37	chr1	22903296	22903296	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccaagatgtactgcagcgCggagggcgagtggctcgtgc	16	11	0	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr1:22903296C>T	uc001bfx.1	+	3	871	c.746C>T	c.(745-747)GCG>GTG	p.A249V	EPHA8_uc001bfw.2_Missense_Mutation_p.A249V	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	249	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TACTGCAGCGCGGAGGGCGAG	0.687													T	22903296	T	T	22903296	3	4	163	1	0	0	0	0	1	0	0	0	5173	768	27	1	756	1	EPHA8	1	22903296	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		22903296	226347325	1	11577											
TSSK3	81629	broad.mit.edu	37	chr1	32828323	32828323	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atggaggactttctgctctcCaatgggtaccagctgggcaa	12	10	2	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr1:32828323C>A	uc001bvf.2	+	1	462	c.21C>A	c.(19-21)TCC>TCA	p.S7S	uc001bve.1_RNA	NM_052841	NP_443073	Q96PN8	TSSK3_HUMAN	testis-specific serine kinase 3	7					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.17)|Breast(348;0.212)				TTCTGCTCTCCAATGGGTACC	0.502													A	32828323	A	A	32828323	2	1	163	1	0	0	0	0	0	0	0	1	16667	581	21	5		5	TSSK3	1	32828323	Silent	SNP	C	TCGA-19-5950-01A-11D-1696-08	9925027	32828323	216422298	2	11578											
GRIK3	2899	broad.mit.edu	37	chr1	37356541	37356541	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cctttttggtcgcctcgaagCtgtcatggaagtgaatcctc	10	11	1	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr1:37356541C>G	uc001caz.2	-	2	407	c.272G>C	c.(271-273)AGC>ACC	p.S91T	GRIK3_uc001cba.1_Missense_Mutation_p.S91T	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	91	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CGCCTCGAAGCTGTCATGGAA	0.527													G	37356541	G	G	37356541	3	3	163	1	0	0	0	0	1	0	0	0	6775	797	28	5	2547	5	GRIK3	1	37356541	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	4528218	37356541	211894080	3	11579											
SDC1	6382	broad.mit.edu	37	chr2	20403674	20403674	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcctctgtgtggggagtgTgaaggtcagcttggctgggt	17	7	2	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr2:20403674T>C	uc002rdo.1	-	3	826	c.527A>G	c.(526-528)CAC>CGC	p.H176R	SDC1_uc002rdp.1_Missense_Mutation_p.H176R|SDC1_uc010exv.2_Intron	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	176	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		GTGGGGAGTGTGAAGGTCAGC	0.662													C	20403674	C	C	20403674	3	2	163	1	0	0	0	0	1	0	0	0	13951	1696	59	4	417	4	SDC1	2	20403674	Missense_Mutation	SNP	T	TCGA-19-5950-01A-11D-1696-08		20403674	222795699	4	11580											
KCNH8	131096	broad.mit.edu	37	chr3	19574895	19574895	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctatccacataggtaacaacAttgactcaggaagtttctca	6	10	2	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr3:19574895A>G	uc003cbk.1	+	16	2823	c.2628A>G	c.(2626-2628)ACA>ACG	p.T876T	KCNH8_uc010hex.1_Silent_p.T337T	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	876	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						AGGTAACAACATTGACTCAGG	0.413													G	19574895	G	G	19574895	2	3	163	1	0	0	0	0	0	0	0	1	8038	204	8	4		4	KCNH8	3	19574895	Silent	SNP	A	TCGA-19-5950-01A-11D-1696-08		19574895	178447535	5	11581											
ERC2	26059	broad.mit.edu	37	chr3	56468977	56468977	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgaggagaccttggcaaaCgaggggatctggaagggcta	16	7	1	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr3:56468977C>T	uc003dhr.1	-	2	315	c.59G>A	c.(58-60)CGT>CAT	p.R20H		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	20						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CCTTGGCAAACGAGGGGATCT	0.468													T	56468977	T	T	56468977	3	4	163	1	0	0	0	0	1	0	0	0	5211	536	19	1	2868	1	ERC2	3	56468977	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	36894082	56468977	141553453	6	11582											
SLC33A1	9197	broad.mit.edu	37	chr3	155547581	155547581	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tactgtagaaggccagtttcCtcccagattggacacggtat	10	10	0	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr3:155547581C>T	uc003fan.3	-	5	1759	c.1378G>A	c.(1378-1380)GGA>AGA	p.G460R	SLC33A1_uc003fao.1_Missense_Mutation_p.G460R|SLC33A1_uc003fap.1_RNA	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	460	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGCCAGTTTCCTCCCAGATTG	0.428													T	155547581	T	T	155547581	3	4	163	1	0	0	0	0	1	0	0	0	14566	690	24	3	279	3	SLC33A1	3	155547581	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	99078604	155547581	42474849	7	11583											
ABCG2	9429	broad.mit.edu	37	chr4	89061129	89061129	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgacactgggataaaaacttCgacattactggaagacatct	8	8	1	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr4:89061129C>T	uc003hrg.2	-	2	512	c.19G>A	c.(19-21)GAA>AAA	p.E7K	ABCG2_uc003hrh.2_Missense_Mutation_p.E7K|ABCG2_uc003hri.1_Missense_Mutation_p.E7K|ABCG2_uc003hrj.1_Missense_Mutation_p.E7K|ABCG2_uc003hrk.1_Missense_Mutation_p.E7K	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	7	Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	ATAAAAACTTCGACATTACTG	0.413													T	89061129	T	T	89061129	3	4	163	1	0	0	0	0	1	0	0	0	69	893	31	2	2008	2	ABCG2	4	89061129	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		89061129	102093147	8	11584											
TRAM1L1	133022	broad.mit.edu	37	chr4	118005603	118005603	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acctctgaagccagagagtaAttaagttccatgttacgtag	9	8	1	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr4:118005603A>G	uc003ibv.3	-	1	1134	c.947T>C	c.(946-948)ATT>ACT	p.I316T		NM_152402	NP_689615	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like	316	Helical; (Potential).|TLC.				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)	1						CCAGAGAGTAATTAAGTTCCA	0.408													G	118005603	G	G	118005603	3	3	163	1	0	0	0	0	1	0	0	0	16449	101	4	4	166	4	TRAM1L1	4	118005603	Missense_Mutation	SNP	A	TCGA-19-5950-01A-11D-1696-08	28944474	118005603	73148673	9	11585											
DNAH5	1767	broad.mit.edu	37	chr5	13901576	13901576	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtttcgagccagaggaggatCgtatttctgctttgtataca	11	7	1	1	rs141072655		TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr5:13901576C>T	uc003jfd.2	-	14	1879	c.1837G>A	c.(1837-1839)GAT>AAT	p.D613N		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	613	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGAGGAGGATCGTATTTCTGC	0.448									Kartagener_syndrome				T	13901576	T	T	13901576	3	4	163	1	0	0	0	0	1	0	0	0	4604	884	31	2	12301	2	DNAH5	5	13901576	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		13901576	167013684	10	11586											
PRDM9	56979	broad.mit.edu	37	chr5	23527545	23527545	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtctgcagggagtgtgggcGgggctttagagataagtcaa	17	5	2	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr5:23527545G>A	uc003jgo.2	+	11	2530	c.2348G>A	c.(2347-2349)CGG>CAG	p.R783Q		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	783	C2H2-type 11.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GAGTGTGGGCGGGGCTTTAGA	0.577										HNSCC(3;0.000094)			A	23527545	A	A	23527545	3	1	163	1	0	0	0	0	1	0	0	0	12463	1116	39	2	2386	2	PRDM9	5	23527545	Missense_Mutation	SNP	G	TCGA-19-5950-01A-11D-1696-08	9625969	23527545	157387715	11	11587											
EMB	133418	broad.mit.edu	37	chr5	49698154	49698154	+	Splice_Site	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctcaaattctttcccctcatCtgtgtaacaaaagaagaatt	4	10	4	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr5:49698154C>T	uc003jom.2	-	7	1127	c.878_splice	c.e7-1	p.D293_splice	EMB_uc010ivq.2_Splice_Site_p.D87_splice|EMB_uc003jol.2_Splice_Site_p.D224_splice|EMB_uc011cpy.1_Splice_Site_p.D243_splice|EMB_uc010ivr.2_Splice_Site_p.D239_splice	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor							integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TTCCCCTCATCTGTGTAACAA	0.318													T	49698154	T	T	49698154	5	4	163	1	0	0	0	0	0	0	1	0	5085	927	32	3	118	3	EMB	5	49698154	Splice_Site	SNP	C	TCGA-19-5950-01A-11D-1696-08	26170609	49698154	131217106	12	11588											
OCLN	4950	broad.mit.edu	37	chr5	68805174	68805174	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttgcctgtgtggcctccaCgcttgcctgggacagaggct	13	13	0	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr5:68805174C>T	uc003jwu.2	+	3	693	c.257C>T	c.(256-258)ACG>ATG	p.T86M	OCLN_uc003jwv.3_Missense_Mutation_p.T86M	NM_002538	NP_002529			occludin												0		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		GTGGCCTCCACGCTTGCCTGG	0.478													T	68805174	T	T	68805174	3	4	163	1	0	0	0	0	1	0	0	0	10820	536	19	1	263	1	OCLN	5	68805174	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	19107020	68805174	112110086	13	11589											
PKHD1	5314	broad.mit.edu	37	chr6	51491843	51491843	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcccttgtgattctcggcGtttggatgagatgtggatat	15	6	1	2	rs151198392		TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr6:51491843G>A	uc003pah.1	-	66	12013	c.11737C>T	c.(11737-11739)CGC>TGC	p.R3913C		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3913	Cytoplasmic (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GATTCTCGGCGTTTGGATGAG	0.433													A	51491843	A	A	51491843	3	1	163	1	0	0	0	0	1	0	0	0	11971	1145	40	1	495	1	PKHD1	6	51491843	Missense_Mutation	SNP	G	TCGA-19-5950-01A-11D-1696-08		51491843	119623224	14	11590											
COL12A1	1303	broad.mit.edu	37	chr6	75898089	75898089	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctactcaccttcttctccaCtaaccaattcaccaagttgt	2	15	5	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr6:75898089C>A	uc003phs.2	-	8	1152	c.986G>T	c.(985-987)AGT>ATT	p.S329I	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_5'UTR	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	329					cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TTCTTCTCCACTAACCAATTC	0.373													A	75898089	A	A	75898089	3	1	163	1	0	0	0	0	1	0	0	0	3669	565	20	5	8441	5	COL12A1	6	75898089	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	24406246	75898089	95216978	15	11591											
DOPEY1	23033	broad.mit.edu	37	chr6	83841949	83841949	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgggacacctcagcatcacCagaagagtgtggaactattt	10	9	2	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr6:83841949C>T	uc003pjs.1	+	18	2931	c.2671C>T	c.(2671-2673)CAG>TAG	p.Q891*	DOPEY1_uc011dyy.1_Nonsense_Mutation_p.Q882*|DOPEY1_uc010kbl.1_Nonsense_Mutation_p.Q882*	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	891					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TCAGCATCACCAGAAGAGTGT	0.373													T	83841949	T	T	83841949	4	4	163	1	0	0	0	0	0	1	0	0	4707	595	21	3	2733	3	DOPEY1	6	83841949	Nonsense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	7943860	83841949	87273118	16	11592											
PREP	5550	broad.mit.edu	37	chr6	105771589	105771589	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttccttttacggtcacctctCggaaaactcttggctccagc	7	14	3	0	rs141737006		TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr6:105771589C>T	uc003prc.2	-	10	1471	c.1268G>A	c.(1267-1269)CGA>CAA	p.R423Q		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	423					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	GGTCACCTCTCGGAAAACTCT	0.408													T	105771589	T	T	105771589	3	4	163	1	0	0	0	0	1	0	0	0	12474	884	31	2	888	2	PREP	6	105771589	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	21929640	105771589	65343478	17	11593											
DNAH11	8701	broad.mit.edu	37	chr7	21939697	21939697	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaggaagattatggacaccCgccaagggaaggtgcatacc	12	9	0	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr7:21939697C>T	uc003svc.2	+	82	13314	c.13283C>T	c.(13282-13284)CCG>CTG	p.P4428L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4428					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TATGGACACCCGCCAAGGGAA	0.488									Kartagener_syndrome				T	21939697	T	T	21939697	3	4	163	1	0	0	0	0	1	0	0	0	4599	652	23	2	13606	2	DNAH11	7	21939697	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		21939697	137198966	18	11594											
PPP1R9A	55607	broad.mit.edu	37	chr7	94879506	94879506	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagagactcaaagccagTatcaggccttggaaaagaaa	9	8	3	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr7:94879506T>C	uc003unp.2	+	9	2551	c.2269T>C	c.(2269-2271)TAT>CAT	p.Y757H	PPP1R9A_uc010lfj.2_Missense_Mutation_p.Y779H|PPP1R9A_uc011kif.1_Missense_Mutation_p.Y757H|PPP1R9A_uc003unq.2_Missense_Mutation_p.Y757H|PPP1R9A_uc011kig.1_Missense_Mutation_p.Y757H	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	757	Interacts with TGN38 (By similarity).|Potential.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TCAAAGCCAGTATCAGGCCTT	0.373										HNSCC(28;0.073)			C	94879506	C	C	94879506	3	2	163	1	0	0	0	0	1	0	0	0	12378	1638	57	4	2369	4	PPP1R9A	7	94879506	Missense_Mutation	SNP	T	TCGA-19-5950-01A-11D-1696-08	72939809	94879506	64259157	19	11595											
IRF5	3663	broad.mit.edu	37	chr7	128585975	128585975	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagtggaaggccaacctgcGctgtgcccttaacaagagcc	11	13	0	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr7:128585975G>A	uc003vog.2	+	3	393	c.272G>A	c.(271-273)CGC>CAC	p.R91H	IRF5_uc010llr.1_Missense_Mutation_p.R91H|IRF5_uc011kot.1_Missense_Mutation_p.R91H|IRF5_uc011kou.1_Missense_Mutation_p.R91H|IRF5_uc010lls.1_Missense_Mutation_p.R91H|IRF5_uc003voh.2_Missense_Mutation_p.R91H|IRF5_uc010llt.2_Missense_Mutation_p.R91H|IRF5_uc003voi.2_Missense_Mutation_p.R91H|IRF5_uc010llu.1_Missense_Mutation_p.R91H|IRF5_uc003vok.2_Missense_Mutation_p.R91H|IRF5_uc003voj.3_Missense_Mutation_p.R91H|IRF5_uc010llv.1_Missense_Mutation_p.R91H|IRF5_uc010llw.1_Missense_Mutation_p.R91H	NM_002200	NP_002191	Q13568	IRF5_HUMAN	interferon regulatory factor 5 isoform a	91	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCAACCTGCGCTGTGCCCTT	0.612													A	128585975	A	A	128585975	3	1	163	1	0	0	0	0	1	0	0	0	7833	1087	38	1	278	1	IRF5	7	128585975	Missense_Mutation	SNP	G	TCGA-19-5950-01A-11D-1696-08	33706469	128585975	30552688	20	11596											
OR2A12	346525	broad.mit.edu	37	chr7	143792799	143792799	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaccaggtggtcctatttgCgggttctgcgttcatcttag	11	10	3	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr7:143792799C>T	uc011kty.1	+	1	599	c.599C>T	c.(598-600)GCG>GTG	p.A200V		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A200V(1)		ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					GTCCTATTTGCGGGTTCTGCG	0.532													T	143792799	T	T	143792799	3	4	163	1	0	0	0	0	1	0	0	0	10975	768	27	1	601	1	OR2A12	7	143792799	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	15206824	143792799	15345864	21	11597											
CSMD1	64478	broad.mit.edu	37	chr8	3057257	3057257	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgatacacgaagtggaagcCgcgggcagaggcaccgctct	14	11	1	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr8:3057257C>T	uc011kwk.1	-	33	5566	c.5176G>A	c.(5176-5178)GGC>AGC	p.G1726S	CSMD1_uc011kwj.1_Missense_Mutation_p.G1118S|CSMD1_uc003wqe.2_Missense_Mutation_p.G882S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1726	Extracellular (Potential).|CUB 10.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAGTGGAAGCCGCGGGCAGAG	0.512													T	3057257	T	T	3057257	3	4	163	1	0	0	0	0	1	0	0	0	3944	652	23	2	5673	2	CSMD1	8	3057257	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		3057257	143306765	22	11598											
MSR1	4481	broad.mit.edu	37	chr8	15978016	15978016	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccaacgcgcacttcccagCgatcgtcacaaattgtaccc	7	16	1	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr8:15978016C>T	uc003wwz.2	-	9	1331	c.1133G>A	c.(1132-1134)CGC>CAC	p.R378H	MSR1_uc010lsu.2_Missense_Mutation_p.R396H|MSR1_uc003wxa.2_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	378	SRCR.|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CACTTCCCAGCGATCGTCACA	0.562													T	15978016	T	T	15978016	3	4	163	1	0	0	0	0	1	0	0	0	9886	768	27	1	230	1	MSR1	8	15978016	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	12920759	15978016	130386006	23	11599											
CDCA2	157313	broad.mit.edu	37	chr8	25341581	25341581	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cccggaagtgtttgatgaatCtttgccagcaaatactccat	8	10	1	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr8:25341581C>A	uc003xep.1	+	10	1699	c.1220C>A	c.(1219-1221)TCT>TAT	p.S407Y	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_Missense_Mutation_p.S407Y|CDCA2_uc003xeq.1_Missense_Mutation_p.S392Y|CDCA2_uc003xer.1_Missense_Mutation_p.S70Y	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	407					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		TTTGATGAATCTTTGCCAGCA	0.428													A	25341581	A	A	25341581	3	1	163	1	0	0	0	0	1	0	0	0	3086	913	32	5	1254	5	CDCA2	8	25341581	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	9363565	25341581	121022441	24	11600											
PKHD1L1	93035	broad.mit.edu	37	chr8	110424605	110424605	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatgttaaaccaaacagaCgaccatatggagatatttta	7	7	0	3			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr8:110424605C>T	uc003yne.2	+	20	2301	c.2197C>T	c.(2197-2199)CGA>TGA	p.R733*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	733	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACCAAACAGACGACCATATGG	0.368										HNSCC(38;0.096)			T	110424605	T	T	110424605	4	4	163	1	0	0	0	0	0	1	0	0	11972	528	19	1	2275	1	PKHD1L1	8	110424605	Nonsense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	85083024	110424605	35939417	25	11601											
DGAT1	8694	broad.mit.edu	37	chr8	145541816	145541818	+	In_Frame_Del	DEL	CTT	-	-													ggggcagcagcactgctggcCttcttccctgcagaggctac							TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr8:145541816_145541818delCTT	uc003zbv.3	-	8	959_961	c.691_693delAAG	c.(691-693)AAGdel	p.K231del	DGAT1_uc010mfv.2_Intron	NM_012079	NP_036211	O75907	DGAT1_HUMAN	diacylglycerol O-acyltransferase 1	231	Helical; (Potential).				triglyceride biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;7.67e-40)|all cancers(56;7.88e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CACTGCTGGCCTTCTTCCCTGCA	0.709													-	145541818	-	-	145541816	7	5	163	1	0	1	0	1	0	0	0	0	4457	680	24	0	813	0	DGAT1	8	145541816	In_Frame_Del	DEL	CTT	TCGA-19-5950-01A-11D-1696-08	35117211	145541816	822206	26	11602											
ZNF250	58500	broad.mit.edu	37	chr8	146108024	146108024	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggcactgcctggtgcggagTgagtggcatgctttggctta	16	8	0	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr8:146108024T>C	uc003zeq.3	-	6	676	c.559A>G	c.(559-561)ACT>GCT	p.T187A	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Missense_Mutation_p.T182A|ZNF250_uc010mgg.2_Missense_Mutation_p.T182A	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		TGGTGCGGAGTGAGTGGCATG	0.498													C	146108024	C	C	146108024	3	2	163	1	0	0	0	0	1	0	0	0	17792	1696	59	4	1127	4	ZNF250	8	146108024	Missense_Mutation	SNP	T	TCGA-19-5950-01A-11D-1696-08	566208	146108024	255998	27	11603											
MOBKL2B	79817	broad.mit.edu	37	chr9	27455216	27455216	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtactggggagctggcagCgctgttggcttcttatactt	13	8	1	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr9:27455216C>T	uc003zqn.2	-	2	829	c.333G>A	c.(331-333)GCG>GCA	p.A111A		NM_024761	NP_079037	Q86TA1	MOL2B_HUMAN	MOB1, Mps One Binder kinase activator-like 2B	111							metal ion binding|protein binding			ovary(1)|pleura(1)	2		all_neural(11;9.12e-11)		Lung(218;6.54e-05)|LUSC - Lung squamous cell carcinoma(38;0.000397)		GAGCTGGCAGCGCTGTTGGCT	0.488													T	27455216	T	T	27455216	2	4	163	1	0	0	0	0	0	0	0	1	9685	755	27	1		1	MOBKL2B	9	27455216	Silent	SNP	C	TCGA-19-5950-01A-11D-1696-08		27455216	113758215	28	11604											
FBP2	8789	broad.mit.edu	37	chr9	97329591	97329591	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcacatattcagtggtggcCgcatcaaaatacttggcata	9	9	2	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr9:97329591C>T	uc004auv.2	-	5	733	c.666G>A	c.(664-666)GCG>GCA	p.A222A	uc004aus.1_Intron|uc004aut.1_Intron|uc004auu.2_Intron	NM_003837	NP_003828	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	222					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)				CAGTGGTGGCCGCATCAAAAT	0.463													T	97329591	T	T	97329591	2	4	163	1	0	0	0	0	0	0	0	1	5706	639	23	2		2	FBP2	9	97329591	Silent	SNP	C	TCGA-19-5950-01A-11D-1696-08	69874375	97329591	43883840	29	11605											
ITIH2	3698	broad.mit.edu	37	chr10	7763617	7763617	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccgttctttctaggcgcaCgtctccttcaagcccacggt	8	16	4	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr10:7763617C>T	uc001ijs.2	+	8	906	c.744C>T	c.(742-744)CAC>CAT	p.H248H		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	248					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TCTAGGCGCACGTCTCCTTCA	0.587													T	7763617	T	T	7763617	2	4	163	1	0	0	0	0	0	0	0	1	7904	535	19	1		1	ITIH2	10	7763617	Silent	SNP	C	TCGA-19-5950-01A-11D-1696-08		7763617	127771130	30	11606											
EXOC6	54536	broad.mit.edu	37	chr10	94653171	94653171	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaagttagatgcttgtatccGtaatcatgacaaggaaattg	9	5	1	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr10:94653171G>A	uc001kig.2	+	2	233	c.167G>A	c.(166-168)CGT>CAT	p.R56H	EXOC6_uc010qnr.1_Missense_Mutation_p.R72H|EXOC6_uc001kie.2_Missense_Mutation_p.R51H|EXOC6_uc001kif.3_Missense_Mutation_p.R56H|EXOC6_uc009xub.2_Missense_Mutation_p.R56H|EXOC6_uc009xuc.2_Missense_Mutation_p.R56H	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	56					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				GCTTGTATCCGTAATCATGAC	0.333													A	94653171	A	A	94653171	3	1	163	1	0	0	0	0	1	0	0	0	5308	1145	40	1	263	1	EXOC6	10	94653171	Missense_Mutation	SNP	G	TCGA-19-5950-01A-11D-1696-08	86889554	94653171	40881576	31	11607											
SORBS1	10580	broad.mit.edu	37	chr10	97194458	97194458	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcagaaatagagcgtgcgcgTaaagggtcggcagttgctga	16	7	0	3			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr10:97194458T>A	uc001kkp.2	-	3	138	c.93A>T	c.(91-93)TTA>TTT	p.L31F	SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Missense_Mutation_p.L19F|SORBS1_uc001kko.2_Missense_Mutation_p.L31F|SORBS1_uc001kkq.2_Missense_Mutation_p.L31F|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Missense_Mutation_p.L31F|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.L31F|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Intron|SORBS1_uc001kkx.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	31					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		AGCGTGCGCGTAAAGGGTCGG	0.483													A	97194458	A	A	97194458	3	1	163	1	0	0	0	0	1	0	0	0	14927	1635	57	5	4098	5	SORBS1	10	97194458	Missense_Mutation	SNP	T	TCGA-19-5950-01A-11D-1696-08	2541287	97194458	38340289	32	11608											
NLRP14	338323	broad.mit.edu	37	chr11	7065151	7065151	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccggtgtttgcggaccatcAggctgtctgtaactgtggta	14	9	2	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr11:7065151A>G	uc001mfb.1	+	4	2217	c.1894A>G	c.(1894-1896)AGG>GGG	p.R632G		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	632					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GCGGACCATCAGGCTGTCTGT	0.423													G	7065151	G	G	7065151	3	3	163	1	0	0	0	0	1	0	0	0	10476	179	7	4	1904	4	NLRP14	11	7065151	Missense_Mutation	SNP	A	TCGA-19-5950-01A-11D-1696-08		7065151	127941365	33	11609											
OR5AN1	390195	broad.mit.edu	37	chr11	59132528	59132528	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	actttctttgtacaggtcatGactgctatattaaccatgtt	6	8	2	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr11:59132528G>A	uc010rks.1	+	1	597	c.597G>A	c.(595-597)ATG>ATA	p.M199I		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TACAGGTCATGACTGCTATAT	0.408													A	59132528	A	A	59132528	3	1	163	1	0	0	0	0	1	0	0	0	11143	1290	45	3	599	3	OR5AN1	11	59132528	Missense_Mutation	SNP	G	TCGA-19-5950-01A-11D-1696-08	52067377	59132528	75873988	34	11610											
ATM	472	broad.mit.edu	37	chr11	108172455	108172455	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acatagtttctgggagatttAtaagatgacaacagatccaa	8	6	1	4			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr11:108172455A>G	uc001pkb.1	+	35	5643	c.5258A>G	c.(5257-5259)TAT>TGT	p.Y1753C	ATM_uc009yxr.1_Missense_Mutation_p.Y1753C|ATM_uc001pke.1_Missense_Mutation_p.Y405C|ATM_uc001pkg.1_Missense_Mutation_p.Y110C|ATM_uc009yxt.1_5'Flank	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1753					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TGGGAGATTTATAAGATGACA	0.343			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			G	108172455	G	G	108172455	3	3	163	1	0	0	0	0	1	0	0	0	1109	449	16	4	5392	4	ATM	11	108172455	Missense_Mutation	SNP	A	TCGA-19-5950-01A-11D-1696-08	49039927	108172455	26834061	35	11611											
BUD13	84811	broad.mit.edu	37	chr11	116633616	116633616	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgaggaaccatgacgggctCgcctaggaggagagggatct	16	9	1	3	rs139478949		TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr11:116633616C>T	uc001ppn.2	-	4	723	c.689G>A	c.(688-690)CGA>CAA	p.R230Q	BUD13_uc001ppo.2_Intron|BUD13_uc009yzc.2_Missense_Mutation_p.R230Q	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	230	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		ATGACGGGCTCGCCTAGGAGG	0.532													T	116633616	T	T	116633616	3	4	163	1	0	0	0	0	1	0	0	0	1573	884	31	2	1198	2	BUD13	11	116633616	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	8461161	116633616	18372900	36	11612											
TIMELESS	8914	broad.mit.edu	37	chr12	56822356	56822356	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatgatgcggctgctctccCtcacagcctcatctggagat	10	13	4	3			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr12:56822356C>T	uc001slf.2	-	12	1553	c.1385G>A	c.(1384-1386)AGG>AAG	p.R462K	TIMELESS_uc001slg.2_Missense_Mutation_p.R461K	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	462					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GCTGCTCTCCCTCACAGCCTC	0.557													T	56822356	T	T	56822356	3	4	163	1	0	0	0	0	1	0	0	0	15901	681	24	3	2313	3	TIMELESS	12	56822356	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		56822356	77029539	37	11613											
KCNC2	3747	broad.mit.edu	37	chr12	75601221	75601221	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggccgccaggtcctcgtcGtcgccggggtcgccgccaat	14	16	0	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr12:75601221G>A	uc001sxg.1	-	2	1087	c.543C>T	c.(541-543)GAC>GAT	p.D181D	KCNC2_uc009zry.2_Silent_p.D181D|KCNC2_uc001sxe.2_Silent_p.D181D|KCNC2_uc001sxf.2_Silent_p.D181D|KCNC2_uc010stw.1_Silent_p.D181D	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	181	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						GGTCCTCGTCGTCGCCGGGGT	0.726													A	75601221	A	A	75601221	2	1	163	1	0	0	0	0	0	0	0	1	8015	1136	40	1		1	KCNC2	12	75601221	Silent	SNP	G	TCGA-19-5950-01A-11D-1696-08	18778865	75601221	58250674	38	11614											
NTN4	59277	broad.mit.edu	37	chr12	96076575	96076575	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gacggaagtcaggaacttcaTgataccagtctatgtctgtg	11	8	4	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr12:96076575T>G	uc001tei.2	-	7	1867	c.1418A>C	c.(1417-1419)CAT>CCT	p.H473P	NTN4_uc009ztf.2_Missense_Mutation_p.H473P|NTN4_uc009ztg.2_Missense_Mutation_p.H436P	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	473					axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						AGGAACTTCATGATACCAGTC	0.423													G	96076575	G	G	96076575	3	3	163	1	0	0	0	0	1	0	0	0	10702	1464	51	5	484	5	NTN4	12	96076575	Missense_Mutation	SNP	T	TCGA-19-5950-01A-11D-1696-08	20475354	96076575	37775320	39	11615											
FOXA1	3169	broad.mit.edu	37	chr14	38061515	38061515	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcgcttgaacgtcttggcGtcgccgccgccgcccgcgcg	14	18	1	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr14:38061515G>A	uc001wuf.2	-	2	786	c.474C>T	c.(472-474)GAC>GAT	p.D158D	FOXA1_uc010tpz.1_Silent_p.D125D	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	158					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		ACGTCTTGGCGTcgccgccgc	0.557													A	38061515	A	A	38061515	2	1	163	1	0	0	0	0	0	0	0	1	5989	1136	40	1		1	FOXA1	14	38061515	Silent	SNP	G	TCGA-19-5950-01A-11D-1696-08		38061515	69288025	40	11616											
TMEM229B	161145	broad.mit.edu	37	chr14	67940157	67940157	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagtcagtcttgacatggcCgttggccagggctagggcgc	15	11	3	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr14:67940157C>T	uc001xjk.2	-	3	894	c.484G>A	c.(484-486)GGC>AGC	p.G162S	TMEM229B_uc001xjj.1_RNA	NM_182526	NP_872332	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	162	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1						TTGACATGGCCGTTGGCCAGG	0.632													T	67940157	T	T	67940157	3	4	163	1	0	0	0	0	1	0	0	0	16145	652	23	2	23	2	TMEM229B	14	67940157	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	29878642	67940157	39409383	41	11617											
RPS6KL1	83694	broad.mit.edu	37	chr14	75388196	75388196	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ccgtgctcgtgagcaaggctCaggctccaggccggggctgg	17	13	1	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr14:75388196C>A	uc010tux.1	-	2	577	c.49G>T	c.(49-51)GAG>TAG	p.E17*	RPS6KL1_uc001xqw.2_Nonsense_Mutation_p.E17*|RPS6KL1_uc010asd.1_RNA|RPS6KL1_uc001xqy.1_Nonsense_Mutation_p.E17*	NM_031464	NP_113652	Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	17						ribosome	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00658)		GAGCAAGGCTCAGGCTCCAGG	0.607													A	75388196	A	A	75388196	4	1	163	1	0	0	0	0	0	1	0	0	13659	835	29	5	1616	5	RPS6KL1	14	75388196	Nonsense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	7448039	75388196	31961344	42	11618											
ACAN	176	broad.mit.edu	37	chr15	89386832	89386832	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacgtgcatgccaaccagaCgggctaccccgacccctcat	8	18	1	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr15:89386832C>T	uc010upo.1	+	6	1378	c.1004C>T	c.(1003-1005)ACG>ATG	p.T335M	ACAN_uc002bmx.2_Missense_Mutation_p.T335M|ACAN_uc010upp.1_Missense_Mutation_p.T335M|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	335					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GCCAACCAGACGGGCTACCCC	0.657													T	89386832	T	T	89386832	3	4	163	1	0	0	0	0	1	0	0	0	117	536	19	1	1022	1	ACAN	15	89386832	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		89386832	13144560	43	11619											
LRRK1	79705	broad.mit.edu	37	chr15	101567475	101567475	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgctcacagtgagatttcCtgcaagagcctggaaggtca	11	9	2	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr15:101567475C>T	uc002bwr.2	+	18	2734	c.2415C>T	c.(2413-2415)TCC>TCT	p.S805S	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	805	Roc.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTGAGATTTCCTGCAAGAGCC	0.562													T	101567475	T	T	101567475	2	4	163	1	0	0	0	0	0	0	0	1	9032	668	24	3		3	LRRK1	15	101567475	Silent	SNP	C	TCGA-19-5950-01A-11D-1696-08	12180643	101567475	963917	44	11620											
WFIKKN2	124857	broad.mit.edu	37	chr17	48917794	48917794	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctggcctgcatgagcgggcCgctggccgcgtgcagcctgc	17	15	0	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr17:48917794C>T	uc002isv.3	+	2	1839	c.1145C>T	c.(1144-1146)CCG>CTG	p.P382L	WFIKKN2_uc010dbu.2_Missense_Mutation_p.P289L	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	382						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			ATGAGCGGGCCGCTGGCCGCG	0.652													T	48917794	T	T	48917794	3	4	163	1	0	0	0	0	1	0	0	0	17356	652	23	2	1151	2	WFIKKN2	17	48917794	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		48917794	32277416	45	11621											
ABCA10	10349	broad.mit.edu	37	chr17	67188731	67188731	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatatccaataccccactttCgcttcagaaacaaagatgat	5	11	1	3	rs138792982	byFrequency	TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr17:67188731C>T	uc010dfa.1	-	17	2723	c.1844G>A	c.(1843-1845)CGA>CAA	p.R615Q	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.R216Q	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	615	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					ACCCCACTTTCGCTTCAGAAA	0.328													T	67188731	T	T	67188731	3	4	163	1	0	0	0	0	1	0	0	0	29	884	31	2	2883	2	ABCA10	17	67188731	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	18270937	67188731	14006479	46	11622											
DNAH17	8632	broad.mit.edu	37	chr17	76557880	76557880	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catttgagctgcccggccacGggaggcatgtttttgtggat	14	9	0	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr17:76557880G>A	uc002jvv.1	-	8	964	c.858C>T	c.(856-858)CCC>CCT	p.P286P						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCCCGGCCACGGGAGGCATGT	0.577													A	76557880	A	A	76557880	2	1	163	1	0	0	0	0	0	0	0	1	4601	1103	39	2		2	DNAH17	17	76557880	Silent	SNP	G	TCGA-19-5950-01A-11D-1696-08	9369149	76557880	4637330	47	11623											
ANKRD12	23253	broad.mit.edu	37	chr18	9258903	9258903	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catatctcctggatggaaacCccttaagcaagatttgtatt	7	9	1	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr18:9258903C>T	uc002knv.2	+	9	5895	c.5638C>T	c.(5638-5640)CCC>TCC	p.P1880S	ANKRD12_uc002knw.2_Missense_Mutation_p.P1857S|ANKRD12_uc002knx.2_Missense_Mutation_p.P1857S|ANKRD12_uc010dkx.1_Missense_Mutation_p.P1587S	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	1880						nucleus				ovary(2)|central_nervous_system(1)	3						GGATGGAAACCCCTTAAGCAA	0.303													T	9258903	T	T	9258903	3	4	163	1	0	0	0	0	1	0	0	0	640	623	22	3	5668	3	ANKRD12	18	9258903	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		9258903	68818345	48	11624											
ATCAY	85300	broad.mit.edu	37	chr19	3907801	3907801	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctatttggggacggcacgaCggaggacggcagcgccgcca	16	12	1	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr19:3907801C>T	uc002lyy.3	+	5	858	c.428C>T	c.(427-429)ACG>ATG	p.T143M	ATCAY_uc010xhz.1_Missense_Mutation_p.T149M|ATCAY_uc010dts.2_5'Flank	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	143					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		GACGGCACGACGGAGGACGGC	0.637													T	3907801	T	T	3907801	3	4	163	1	0	0	0	0	1	0	0	0	1077	536	19	1	442	1	ATCAY	19	3907801	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08		3907801	55221182	49	11625											
HOMER3	9454	broad.mit.edu	37	chr19	19043763	19043784	+	Frame_Shift_Del	DEL	CGCTCTGTGGGGCCGGGGGCAT	-	-													acatcttctttagccgctcgCgctctgtggggccgggggca					rs147820524	byFrequency	TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr19:19043763_19043784delCGCTCTGTGGGGCCGGGGGCAT	uc002nku.2	-	5	1135_1156	c.482_503delATGCCCCCGGCCCCACAGAGCG	c.(481-504)GATGCCCCCGGCCCCACAGAGCGCfs	p.D161fs	HOMER3_uc002nko.1_RNA|HOMER3_uc002nkp.1_RNA|HOMER3_uc010eby.2_Frame_Shift_Del_p.D125fs|HOMER3_uc010ebz.2_Frame_Shift_Del_p.D161fs|HOMER3_uc002nkw.2_Frame_Shift_Del_p.D161fs|HOMER3_uc002nkv.2_Frame_Shift_Del_p.D161fs	NM_004838	NP_004829	Q9NSC5	HOME3_HUMAN	Homer, neuronal immediate early gene, 3 isoform	161_168					metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding				0			Epithelial(12;0.0107)			TAGCCGCTCGCGCTCTGTGGGGCCGGGGGCATCAGCGCTCTG	0.437													-	19043784	-	-	19043763	7	5	163	1	0	1	0	1	0	0	0	0	7280	768	27	0	602	0	HOMER3	19	19043763	Frame_Shift_Del	DEL	CGCTCTGTGGGGCCGGGGGCAT	TCGA-19-5950-01A-11D-1696-08	15135962	19043763	40085220	50	11626											
LSM14A	26065	broad.mit.edu	37	chr19	34710329	34710329	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagctccaaggagagggcGtgggggtcatcggggtggca	19	8	2	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr19:34710329G>A	uc002nvb.3	+	7	1011	c.815G>A	c.(814-816)CGT>CAT	p.R272H	LSM14A_uc002nva.3_Missense_Mutation_p.R272H|LSM14A_uc010xru.1_Missense_Mutation_p.R231H|LSM14A_uc002nvc.3_Missense_Mutation_p.R78H	NM_001114093	NP_001107565	Q8ND56	LS14A_HUMAN	LSM14 homolog A isoform a	272					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				skin(1)	1	Esophageal squamous(110;0.162)					AGGAGAGGGCGTGGGGGTCAT	0.443													A	34710329	A	A	34710329	3	1	163	1	0	0	0	0	1	0	0	0	9054	1145	40	1	841	1	LSM14A	19	34710329	Missense_Mutation	SNP	G	TCGA-19-5950-01A-11D-1696-08	15666566	34710329	24418654	51	11627											
CHGB	1114	broad.mit.edu	37	chr20	5903378	5903378	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagccaggagagacacaaaaCgcttttctcaatgaaagaaa	9	8	1	3	rs149359798	by1000genomes	TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr20:5903378C>T	uc002wmg.2	+	4	894	c.588C>T	c.(586-588)AAC>AAT	p.N196N	CHGB_uc010zqz.1_Translation_Start_Site	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	196						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						AGACACAAAACGCTTTTCTCA	0.483													T	5903378	T	T	5903378	2	4	163	1	0	0	0	0	0	0	0	1	3339	535	19	1		1	CHGB	20	5903378	Silent	SNP	C	TCGA-19-5950-01A-11D-1696-08		5903378	57122142	52	11628											
CD93	22918	broad.mit.edu	37	chr20	23066544	23066544	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccttctctcgctggagccCaatccagaacttgctcatcc	7	17	2	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr20:23066544C>T	uc002wsv.2	-	1	434	c.286G>A	c.(286-288)GGG>AGG	p.G96R		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	96	Extracellular (Potential).|C-type lectin.				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGCTGGAGCCCAATCCAGAAC	0.642													T	23066544	T	T	23066544	3	4	163	1	0	0	0	0	1	0	0	0	3047	594	21	3	1680	3	CD93	20	23066544	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	17163166	23066544	39958976	53	11629											
REM1	28954	broad.mit.edu	37	chr20	30070096	30070096	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tccctctcctgcaggataaaAgctggagccaggagtcatgc	11	12	2	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr20:30070096A>T	uc002wwa.2	+	4	714	c.430A>T	c.(430-432)AGC>TGC	p.S144C		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	144					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GCAGGATAAAAGCTGGAGCCA	0.587													T	30070096	T	T	30070096	3	4	163	1	0	0	0	0	1	0	0	0	13222	72	3	5	440	5	REM1	20	30070096	Missense_Mutation	SNP	A	TCGA-19-5950-01A-11D-1696-08	7003552	30070096	32955424	54	11630											
RBL1	5933	broad.mit.edu	37	chr20	35690525	35690525	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaggttatactccacattagCctgtgctgtcagtttcccta	7	11	1	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr20:35690525C>A	uc002xgi.2	-	8	1124	c.1045G>T	c.(1045-1047)GCT>TCT	p.A349S	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.A349S|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	349					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				TCCACATTAGCCTGTGCTGTC	0.423													A	35690525	A	A	35690525	3	1	163	1	0	0	0	0	1	0	0	0	13109	739	26	5	2230	5	RBL1	20	35690525	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	5620429	35690525	27334995	55	11631											
KRTAP11-1	337880	broad.mit.edu	37	chr21	32253366	32253366	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacacttagcaggttcttcGgcagctggacacgcaggact	11	12	1	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chr21:32253366G>A	uc002yov.2	-	1	509	c.478C>T	c.(478-480)CGA>TGA	p.R160*		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	160						keratin filament	structural molecule activity			pancreas(1)	1						CAGGTTCTTCGGCAGCTGGAC	0.562													A	32253366	A	A	32253366	4	1	163	1	0	0	0	0	0	1	0	0	8517	1124	39	2	17	2	KRTAP11-1	21	32253366	Nonsense_Mutation	SNP	G	TCGA-19-5950-01A-11D-1696-08		32253366	15876529	56	11632											
ARSE	415	broad.mit.edu	37	chrX	2873479	2873479	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatcgcacagggtatctgccCgtgaggaaggcggctctgct	15	11	2	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:2873479C>T	uc004crc.3	-	4	535	c.285G>A	c.(283-285)ACG>ACA	p.T95T	ARSE_uc011mhi.1_Silent_p.T41T|ARSE_uc011mhh.1_Silent_p.T120T	NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	95					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTATCTGCCCGTGAGGAAGG	0.527													T	2873479	T	T	2873479	2	4	163	1	0	0	0	0	0	0	0	1	990	639	23	2		2	ARSE	23	2873479	Silent	SNP	C	TCGA-19-5950-01A-11D-1696-08		2873479	152397081	57	11633											
TLR7	51284	broad.mit.edu	37	chrX	12903821	12903821	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aattcctggaggtattcccaCgaacaccacgaacctcaccc	6	16	1	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:12903821C>T	uc004cvc.2	+	3	333	c.194C>T	c.(193-195)ACG>ATG	p.T65M		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	65	Extracellular (Potential).|LRR 2.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	GGTATTCCCACGAACACCACG	0.488													T	12903821	T	T	12903821	3	4	163	1	0	0	0	0	1	0	0	0	15953	536	19	1	200	1	TLR7	23	12903821	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	10030342	12903821	142366739	58	11634											
DMD	1756	broad.mit.edu	37	chrX	32407637	32407637	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ccacacaatgatttagctgtGactgtactacttcctgttcc	6	12	0	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:32407637G>A	uc004dda.1	-	32	4743	c.4499C>T	c.(4498-4500)TCA>TTA	p.S1500L	DMD_uc004dcw.2_Missense_Mutation_p.S156L|DMD_uc004dcx.2_Missense_Mutation_p.S159L|DMD_uc004dcz.2_Missense_Mutation_p.S1377L|DMD_uc004dcy.1_Missense_Mutation_p.S1496L|DMD_uc004ddb.1_Missense_Mutation_p.S1492L|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1500	Spectrin 10.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATTTAGCTGTGACTGTACTAC	0.393													A	32407637	A	A	32407637	3	1	163	1	0	0	0	0	1	0	0	0	4580	1294	45	3	6898	3	DMD	23	32407637	Missense_Mutation	SNP	G	TCGA-19-5950-01A-11D-1696-08	19503816	32407637	122862923	59	11635											
P2RY10	27334	broad.mit.edu	37	chrX	78216970	78216970	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttcgtgaccaactatcccGccatggcagttctgtgaccc	9	14	1	2			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:78216970G>A	uc004ede.2	+	4	1322	c.953G>A	c.(952-954)CGC>CAC	p.R318H	P2RY10_uc004edf.2_Missense_Mutation_p.R318H	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	318	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CAACTATCCCGCCATGGCAGT	0.438													A	78216970	A	A	78216970	3	1	163	1	0	0	0	0	1	0	0	0	11347	1087	38	1	955	1	P2RY10	23	78216970	Missense_Mutation	SNP	G	TCGA-19-5950-01A-11D-1696-08	45809333	78216970	77053590	60	11636											
RPA4	29935	broad.mit.edu	37	chrX	96139918	96139918	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccgcaatttcatccaggaCgaagtgctgcgtttgattca	9	11	2	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:96139918C>T	uc004efv.3	+	1	907	c.609C>T	c.(607-609)GAC>GAT	p.D203D	DIAPH2_uc004eft.3_Intron|DIAPH2_uc004efu.3_Intron|DIAPH2_uc004efs.2_Intron	NM_013347	NP_037479	Q13156	RFA4_HUMAN	replication protein A4, 34kDa	203					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding				0						TCATCCAGGACGAAGTGCTGC	0.522								Other_identified_genes_with_known_or_suspected_DNA_repair_function					T	96139918	T	T	96139918	2	4	163	1	0	0	0	0	0	0	0	1	13539	535	19	1		1	RPA4	23	96139918	Silent	SNP	C	TCGA-19-5950-01A-11D-1696-08	17922948	96139918	59130642	61	11637											
RAB9B	51209	broad.mit.edu	37	chrX	103080537	103080537	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgccctgcagtgtcccagaTctggagggttacaaagcgtc	12	12	1	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:103080537T>C	uc004ell.1	-	3	463	c.178A>G	c.(178-180)ATC>GTC	p.I60V	RAB9B_uc004eli.1_Intron	NM_016370	NP_057454	Q9NP90	RAB9B_HUMAN	RAB9B, member RAS oncogene family	60					Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(3)	3						GTGTCCCAGATCTGGAGGGTT	0.507													C	103080537	C	C	103080537	3	2	163	1	0	0	0	0	1	0	0	0	12959	1435	50	4	431	4	RAB9B	23	103080537	Missense_Mutation	SNP	T	TCGA-19-5950-01A-11D-1696-08	6940619	103080537	52190023	62	11638											
KLHL13	90293	broad.mit.edu	37	chrX	117043525	117043525	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catgggggctaacgatttccActcatgggccttttcatcat	9	11	3	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:117043525A>T	uc004eql.2	-	5	1167	c.1105T>A	c.(1105-1107)TGG>AGG	p.W369R	KLHL13_uc004eqk.2_Missense_Mutation_p.W318R|KLHL13_uc011mtn.1_Missense_Mutation_p.W209R|KLHL13_uc011mto.1_Missense_Mutation_p.W363R|KLHL13_uc011mtp.1_Missense_Mutation_p.W371R|KLHL13_uc004eqm.2_Missense_Mutation_p.W318R|KLHL13_uc011mtq.1_Missense_Mutation_p.W353R	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	369	Kelch 1.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						AACGATTTCCACTCATGGGCC	0.493													T	117043525	T	T	117043525	3	4	163	1	0	0	0	0	1	0	0	0	8369	159	6	5	874	5	KLHL13	23	117043525	Missense_Mutation	SNP	A	TCGA-19-5950-01A-11D-1696-08	13962988	117043525	38227035	63	11639											
MAGEA8	4107	broad.mit.edu	37	chrX	149013837	149013837	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacctggagtaccgccaggCgcccggcagtgatcctgtgc	13	15	0	1			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:149013837C>T	uc004fdw.1	+	3	1006	c.791C>T	c.(790-792)GCG>GTG	p.A264V		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	264	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					TACCGCCAGGCGCCCGGCAGT	0.577													T	149013837	T	T	149013837	3	4	163	1	0	0	0	0	1	0	0	0	9171	768	27	1	793	1	MAGEA8	23	149013837	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	31970312	149013837	6256723	64	11640											
PNCK	139728	broad.mit.edu	37	chrX	152937465	152937465	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcggtcaaacagctcgccaCccgtcaccctgggggtgcca	12	16	2	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:152937465C>T	uc011myu.1	-	5	719	c.533G>A	c.(532-534)GGT>GAT	p.G178D	PNCK_uc011myt.1_Missense_Mutation_p.G112D|PNCK_uc004fia.2_Missense_Mutation_p.G107D|PNCK_uc004fhz.3_Translation_Start_Site|PNCK_uc010nuh.2_3'UTR|PNCK_uc011myv.1_Missense_Mutation_p.G122D|PNCK_uc011myw.1_Missense_Mutation_p.G122D	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	95	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCTCGCCACCCGTCACCCT	0.662													T	152937465	T	T	152937465	3	4	163	1	0	0	0	0	1	0	0	0	12145	507	18	3	775	3	PNCK	23	152937465	Missense_Mutation	SNP	C	TCGA-19-5950-01A-11D-1696-08	3923628	152937465	2333095	65	11641											
RAB39B	116442	broad.mit.edu	37	chrX	154490194	154490194	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agccctcctggattgtaatcTccccccttttaaccagctca	5	16	2	0			TCGA-19-5950-01A-11D-1696-08	TCGA-19-5950-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	8d6626e2-ea32-4b1d-8f2b-389294121692	713b4752-50da-4548-a5a9-b45e9b496f4c	g.chrX:154490194T>C	uc004fne.2	-	2	815	c.536A>G	c.(535-537)GAG>GGG	p.E179G		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	179					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GATTGTAATCTCCCCCCTTTT	0.463													C	154490194	C	C	154490194	3	2	163	1	0	0	0	0	1	0	0	0	12930	1551	54	4	109	4	RAB39B	23	154490194	Missense_Mutation	SNP	T	TCGA-19-5950-01A-11D-1696-08	1552729	154490194	780366	66	11642											
KIF17	57576	broad.mit.edu	37	chr1	21009246	21009246	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtccccgctgtcctcatccGagttctgcagggcagccacc	10	17	2	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr1:21009246G>A	uc001bdr.3	-	11	2481	c.2363C>T	c.(2362-2364)TCG>TTG	p.S788L	KIF17_uc001bdp.3_Missense_Mutation_p.S66L|KIF17_uc001bdq.3_Missense_Mutation_p.S66L|KIF17_uc009vpx.2_Missense_Mutation_p.S158L|KIF17_uc001bds.3_Missense_Mutation_p.S788L	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	788	Potential.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GTCCTCATCCGAGTTCTGCAG	0.607													A	21009246	A	A	21009246	3	1	164	1	0	0	0	0	1	0	0	0	8279	1059	37	2	746	2	KIF17	1	21009246	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08		21009246	228241375	1	11643											
DNALI1	7802	broad.mit.edu	37	chr1	38025070	38025070	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacaggcatctgccctgtcCgcagggaactctactcacag	9	14	3	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr1:38025070C>T	uc001cbj.2	+	3	446	c.436C>T	c.(436-438)CGC>TGC	p.R146C	DNALI1_uc010oie.1_Intron	NM_003462	NP_003453	O14645	IDLC_HUMAN	dynein, axonemal, light intermediate chain 1	124					cellular component movement|single fertilization	axonemal dynein complex	microtubule motor activity			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTGCCCTGTCCGCAGGGAACT	0.587													T	38025070	T	T	38025070	3	4	164	1	0	0	0	0	1	0	0	0	4659	652	23	2	446	2	DNALI1	1	38025070	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	17015824	38025070	211225551	2	11644											
TIE1	7075	broad.mit.edu	37	chr1	43784978	43784978	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctccaagattgcagacttcGgcctttctcggggagaggag	13	11	1	3			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr1:43784978G>T	uc001ciu.2	+	18	3074	c.2995G>T	c.(2995-2997)GGC>TGC	p.G999C	TIE1_uc010oke.1_Missense_Mutation_p.G954C|TIE1_uc009vwq.2_Missense_Mutation_p.G955C|TIE1_uc010okg.1_Missense_Mutation_p.G644C	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	999	Cytoplasmic (Potential).|Protein kinase.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCAGACTTCGGCCTTTCTCG	0.577													T	43784978	T	T	43784978	3	4	164	1	0	0	0	0	1	0	0	0	15890	1116	39	5	3065	5	TIE1	1	43784978	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	5759908	43784978	205465643	3	11645											
LCE3A	353142	broad.mit.edu	37	chr1	152595450	152595450	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	actcaggcagcagctgcgctCggagctgggcccacagcccc	13	17	1	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr1:152595450C>T	uc010pdt.1	-	1	130	c.130G>A	c.(130-132)GAG>AAG	p.E44K		NM_178431	NP_848518	Q5TA76	LCE3A_HUMAN	late cornified envelope 3A	44					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGCTGCGCTCGGAGCTGGGC	0.657													T	152595450	T	T	152595450	3	4	164	1	0	0	0	0	1	0	0	0	8669	893	31	2	142	2	LCE3A	1	152595450	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	108810472	152595450	96655171	4	11646											
HMCN1	83872	broad.mit.edu	37	chr1	186045741	186045741	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgacctcaagtgataaagtAttgattttgccaggtaaaga	9	6	1	4			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr1:186045741A>G	uc001grq.1	+	54	8701	c.8472A>G	c.(8470-8472)GTA>GTG	p.V2824V		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2824	Ig-like C2-type 26.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTGATAAAGTATTGATTTTGC	0.428													G	186045741	G	G	186045741	2	3	164	1	0	0	0	0	0	0	0	1	7220	436	16	4		4	HMCN1	1	186045741	Silent	SNP	A	TCGA-19-5951-01A-11D-1696-08	33450291	186045741	63204880	5	11647											
LEFTY2	7044	broad.mit.edu	37	chr1	226127598	226127598	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccggctcctggaagagccGcagcacggcctgcaccagct	13	16	0	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr1:226127598G>A	uc001hpt.1	-	2	435	c.355C>T	c.(355-357)CGG>TGG	p.R119W	LEFTY2_uc010pvk.1_Intron|LEFTY2_uc009xek.1_Intron	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor	119					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					TGGAAGAGCCGCAGCACGGCC	0.741													A	226127598	A	A	226127598	3	1	164	1	0	0	0	0	1	0	0	0	8716	1086	38	1	757	1	LEFTY2	1	226127598	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	40081857	226127598	23123023	6	11648											
OR2T1	26696	broad.mit.edu	37	chr1	248569915	248569915	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgggggctctttggatggctTcctcctaacccccatcacca	9	15	2	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr1:248569915T>C	uc010pzm.1	+	1	620	c.620T>C	c.(619-621)TTC>TCC	p.F207S		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	207	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGGATGGCTTCCTCCTAACC	0.537													C	248569915	C	C	248569915	3	2	164	1	0	0	0	0	1	0	0	0	11016	1783	62	4	622	4	OR2T1	1	248569915	Missense_Mutation	SNP	T	TCGA-19-5951-01A-11D-1696-08	22442317	248569915	680706	7	11649											
CCDC148	130940	broad.mit.edu	37	chr2	159215014	159215015	+	Frame_Shift_Ins	INS	-	T	T													gcttcagttaatgcacgcaaINSttgttgatagtctactggtt							TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr2:159215014_159215015insT	uc002tzq.2	-	2	356_357	c.93_94insA	c.(91-96)CAATTGfs	p.Q31fs	CCDC148_uc002tzr.2_5'UTR|CCDC148_uc010foh.2_5'UTR|CCDC148_uc010foi.1_Intron|CCDC148_uc010foj.1_5'UTR|CCDC148_uc010fok.1_Intron|CCDC148_uc002tzs.1_Frame_Shift_Ins_p.Q31fs	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	31_32										ovary(2)	2						AATGCACGCAATTGTTGATAGT	0.322													T	159215015	T	T	159215014	7	5	164	1	0	1	1	0	0	0	0	0	2782	98	4	0	1785	0	CCDC148	2	159215014	Frame_Shift_Ins	INS	-	TCGA-19-5951-01A-11D-1696-08		159215014	83984359	8	11650											
ITGB6	3694	broad.mit.edu	37	chr2	160993973	160993973	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcagccctttgtgtctcacGcaggagaaattgtcacactg	10	11	2	1	rs61737765	byFrequency	TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr2:160993973G>A	uc002ubh.2	-	10	1648	c.1632C>T	c.(1630-1632)TGC>TGT	p.C544C	ITGB6_uc010fou.2_Silent_p.C544C|ITGB6_uc010zcq.1_Silent_p.C502C|ITGB6_uc010fov.1_Silent_p.C544C	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	544	Extracellular (Potential).|III.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						TGTGTCTCACGCAGGAGAAAT	0.488													A	160993973	A	A	160993973	2	1	164	1	0	0	0	0	0	0	0	1	7899	1079	38	1		1	ITGB6	2	160993973	Silent	SNP	G	TCGA-19-5951-01A-11D-1696-08	1778959	160993973	82205400	9	11651											
COL6A3	1293	broad.mit.edu	37	chr2	238275681	238275681	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggcccaccttagtgttggCgtgtcttccccctttgtaga	10	12	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr2:238275681C>T	uc002vwl.2	-	11	5434	c.5149G>A	c.(5149-5151)GCC>ACC	p.A1717T	COL6A3_uc002vwo.2_Missense_Mutation_p.A1511T|COL6A3_uc010znj.1_Missense_Mutation_p.A1110T	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1717	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTAGTGTTGGCGTGTCTTCCC	0.542													T	238275681	T	T	238275681	3	4	164	1	0	0	0	0	1	0	0	0	3701	768	27	1	4520	1	COL6A3	2	238275681	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	77281708	238275681	4923692	10	11652											
BSN	8927	broad.mit.edu	37	chr3	49689184	49689184	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaggtggggagcagcatgcGgcctttgctgcaggcccagg	17	11	0	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr3:49689184G>A	uc003cxe.3	+	5	2309	c.2195G>A	c.(2194-2196)CGG>CAG	p.R732Q		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	732					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGCAGCATGCGGCCTTTGCTG	0.667													A	49689184	A	A	49689184	3	1	164	1	0	0	0	0	1	0	0	0	1530	1116	39	2	2213	2	BSN	3	49689184	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08		49689184	148333246	11	11653											
SEMA3G	56920	broad.mit.edu	37	chr3	52475289	52475289	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagctcttaccacgcagacGcggcccacgcggctgacagt	11	17	1	2	rs138050174		TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr3:52475289G>A	uc003dea.1	-	7	804	c.804C>T	c.(802-804)CGC>CGT	p.R268R		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	268	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CCACGCAGACGCGGCCCACGC	0.612													A	52475289	A	A	52475289	2	1	164	1	0	0	0	0	0	0	0	1	14030	1074	38	1		1	SEMA3G	3	52475289	Silent	SNP	G	TCGA-19-5951-01A-11D-1696-08	2786105	52475289	145547141	12	11654											
PLXNA1	5361	broad.mit.edu	37	chr3	126733439	126733439	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtgggcaaggtgctgtgcaGccctgtggagagcgagtaca	17	9	0	1	rs138171477		TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr3:126733439G>A	uc003ejg.2	+	12	2658	c.2654G>A	c.(2653-2655)AGC>AAC	p.S885N		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	908	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		GTGCTGTGCAGCCCTGTGGAG	0.577													A	126733439	A	A	126733439	3	1	164	1	0	0	0	0	1	0	0	0	12119	971	34	3	2769	3	PLXNA1	3	126733439	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	74258150	126733439	71288991	13	11655											
D4S234E	27065	broad.mit.edu	37	chr4	4411320	4411320	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtctccgtgttggtcctcttCgccctggccttcctcacctg	9	17	3	0	rs143847165		TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr4:4411320C>T	uc011bvz.1	+	7	1548	c.267C>T	c.(265-267)TTC>TTT	p.F89F	D4S234E_uc011bwa.1_Silent_p.F50F|D4S234E_uc003ghz.2_Silent_p.F89F|D4S234E_uc003gia.2_Silent_p.F89F|D4S234E_uc003gib.2_Silent_p.F89F	NM_014392	NP_055207	P42857	NSG1_HUMAN	brain neuron cytoplasmic protein 1	89	Helical; Signal-anchor for type II membrane protein; (Potential).				dopamine receptor signaling pathway	Golgi membrane|integral to membrane|nucleus	dopamine receptor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)		TGGTCCTCTTCGCCCTGGCCT	0.617													T	4411320	T	T	4411320	2	4	164	1	0	0	0	0	0	0	0	1	4214	883	31	2		2	D4S234E	4	4411320	Silent	SNP	C	TCGA-19-5951-01A-11D-1696-08		4411320	186742956	14	11656											
UGT2A3	79799	broad.mit.edu	37	chr4	69795715	69795715	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgcttggctcctttgtggCgcatgacaaactcgatccag	12	11	0	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr4:69795715C>T	uc003hef.2	-	6	1431	c.1400G>A	c.(1399-1401)CGC>CAC	p.R467H	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	467	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TCCTTTGTGGCGCATGACAAA	0.488													T	69795715	T	T	69795715	3	4	164	1	0	0	0	0	1	0	0	0	16952	768	27	1	187	1	UGT2A3	4	69795715	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	65384395	69795715	121358561	15	11657											
EGF	1950	broad.mit.edu	37	chr4	110864421	110864421	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attttgcagagagtatgtaaTatagagaaaaatgtttctgg	10	2	1	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr4:110864421T>C	uc003hzy.3	+	3	791	c.339T>C	c.(337-339)AAT>AAC	p.N113N	EGF_uc011cfu.1_Silent_p.N113N|EGF_uc011cfv.1_Silent_p.N113N	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	113	LDL-receptor class B 1.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GAGTATGTAATATAGAGAAAA	0.249													C	110864421	C	C	110864421	2	2	164	1	0	0	0	0	0	0	0	1	4962	1403	49	4		4	EGF	4	110864421	Silent	SNP	T	TCGA-19-5951-01A-11D-1696-08	41068706	110864421	80289855	16	11658											
FAT4	79633	broad.mit.edu	37	chr4	126241369	126241369	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtacctctggtcaggtaaCactaattggcaaattagact	8	9	2	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr4:126241369C>T	uc003ifj.3	+	1	3803	c.3803C>T	c.(3802-3804)ACA>ATA	p.T1268I		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1268	Cadherin 12.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGTCAGGTAACACTAATTGGC	0.373													T	126241369	T	T	126241369	3	4	164	1	0	0	0	0	1	0	0	0	5692	478	17	3	3805	3	FAT4	4	126241369	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	15376948	126241369	64912907	17	11659											
INPP4B	8821	broad.mit.edu	37	chr4	143159105	143159105	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacatctgctctcgaattcGcatccacttattgtcagatg	7	11	3	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr4:143159105G>A	uc003iix.3	-	13	1343	c.748C>T	c.(748-750)CGA>TGA	p.R250*	INPP4B_uc003iiw.3_Nonsense_Mutation_p.R250*|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Nonsense_Mutation_p.R65*|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Nonsense_Mutation_p.R121*	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	250					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					TCTCGAATTCGCATCCACTTA	0.318													A	143159105	A	A	143159105	4	1	164	1	0	0	0	0	0	1	0	0	7753	1095	38	1	2086	1	INPP4B	4	143159105	Nonsense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	16917736	143159105	47995171	18	11660											
SH3RF1	57630	broad.mit.edu	37	chr4	170043337	170043337	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cccattccagcagcagcagcAgcggcggtggcgcctggtgg	16	14	0	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr4:170043337A>G	uc003isa.1	-	7	1595	c.1260T>C	c.(1258-1260)GCT>GCC	p.A420A	SH3RF1_uc010irc.1_Silent_p.A120A	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	420	Poly-Ala.					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		CAGCAGCAGCAGCGGCGGTGG	0.582													G	170043337	G	G	170043337	2	3	164	1	0	0	0	0	0	0	0	1	14258	175	7	4		4	SH3RF1	4	170043337	Silent	SNP	A	TCGA-19-5951-01A-11D-1696-08	26884232	170043337	21110939	19	11661											
DNAH5	1767	broad.mit.edu	37	chr5	13719110	13719110	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcggtggtcatccagaggCggaacgcatcatgtacaagc	12	12	2	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr5:13719110C>T	uc003jfd.2	-	72	12422	c.12380G>A	c.(12379-12381)CGC>CAC	p.R4127H	DNAH5_uc003jfc.2_Missense_Mutation_p.R295H	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4127	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CATCCAGAGGCGGAACGCATC	0.493									Kartagener_syndrome				T	13719110	T	T	13719110	3	4	164	1	0	0	0	0	1	0	0	0	4604	768	27	1	1526	1	DNAH5	5	13719110	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08		13719110	167196150	20	11662											
TRIO	7204	broad.mit.edu	37	chr5	14462975	14462975	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggccgacgccgtgcccctgCcgccacccatggccatccag	12	20	0	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr5:14462975C>G	uc003jff.2	+	36	5614	c.5608C>G	c.(5608-5610)CCG>GCG	p.P1870A	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Missense_Mutation_p.P1519A|TRIO_uc003jfi.1_Missense_Mutation_p.P173A	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1870					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CGTGCCCCTGCCGCCACCCAT	0.652													G	14462975	G	G	14462975	3	3	164	1	0	0	0	0	1	0	0	0	16549	739	26	5	5750	5	TRIO	5	14462975	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	743865	14462975	166452285	21	11663											
GDNF	2668	broad.mit.edu	37	chr5	37816010	37816010	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccagacccaagtcagtgaCatttaaatgtattgcagtta	8	9	1	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr5:37816010C>T	uc011cpi.1	-	3	579	c.379G>A	c.(379-381)GTC>ATC	p.V127I	GDNF_uc011cpc.1_Missense_Mutation_p.V49I|GDNF_uc011cpd.1_Missense_Mutation_p.V75I|GDNF_uc011cpe.1_Missense_Mutation_p.V101I|GDNF_uc011cpf.1_Missense_Mutation_p.V101I|GDNF_uc011cpg.1_Missense_Mutation_p.V144I|GDNF_uc011cph.1_Missense_Mutation_p.V118I	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	127					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					AAGTCAGTGACATTTAAATGT	0.493													T	37816010	T	T	37816010	3	4	164	1	0	0	0	0	1	0	0	0	6322	478	17	3	259	3	GDNF	5	37816010	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	23353035	37816010	143099250	22	11664											
PIK3R1	5295	broad.mit.edu	37	chr5	67589199	67589213	+	In_Frame_Del	DEL	TAACCTTCAGTTCTG	-	-													atatggcttctctgacccatTaaccttcagttctgtggttg							TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr5:67589199_67589213delTAACCTTCAGTTCTG	uc003jva.2	+	10	1747_1761	c.1187_1201delTAACCTTCAGTTCTG	c.(1186-1203)TTAACCTTCAGTTCTGTG>TTG	p.TFSSV397del	PIK3R1_uc003jvb.2_In_Frame_Del_p.TFSSV397del|PIK3R1_uc003jvc.2_In_Frame_Del_p.TFSSV97del|PIK3R1_uc003jvd.2_In_Frame_Del_p.TFSSV127del|PIK3R1_uc003jve.2_In_Frame_Del_p.TFSSV76del|PIK3R1_uc011crb.1_In_Frame_Del_p.TFSSV67del	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	397_401	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TCTGACCCATTAACCTTCAGTTCTGTGGTTGAATT	0.326			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67589213	-	-	67589199	7	5	164	1	0	1	0	1	0	0	0	0	11918	1764	61	0	1351	0	PIK3R1	5	67589199	In_Frame_Del	DEL	TAACCTTCAGTTCTG	TCGA-19-5951-01A-11D-1696-08	29773189	67589199	113326061	23	11665											
PCDHA6	56142	broad.mit.edu	37	chr5	140208958	140208958	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgagttggtggtaaccgcgCgggacgggggctcgccttcg	18	10	0	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr5:140208958C>T	uc003lho.2	+	1	1309	c.1282C>T	c.(1282-1284)CGG>TGG	p.R428W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.R428W|PCDHA6_uc011dab.1_Missense_Mutation_p.R428W	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	428	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTAACCGCGCGGGACGGGGG	0.617													T	140208958	T	T	140208958	3	4	164	1	0	0	0	0	1	0	0	0	11528	759	27	1	1284	1	PCDHA6	5	140208958	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	72619759	140208958	40706302	24	11666											
PCDHGA4	56111	broad.mit.edu	37	chr5	140735359	140735359	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccagagctggtgctggaaCgcgctctagatcgcgaggaa	14	11	1	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr5:140735359C>T	uc003ljq.1	+	1	592	c.592C>T	c.(592-594)CGC>TGC	p.R198C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.R198C	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	198	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCTGGAACGCGCTCTAGA	0.562													T	140735359	T	T	140735359	3	4	164	1	0	0	0	0	1	0	0	0	11556	536	19	1	594	1	PCDHGA4	5	140735359	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	526401	140735359	40179901	25	11667											
PPARGC1B	133522	broad.mit.edu	37	chr5	149219665	149219665	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccggcacgccaggaagcggCgggaaaaggccattgtaagt	15	10	0	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr5:149219665C>T	uc003lrc.2	+	9	2722	c.2680C>T	c.(2680-2682)CGG>TGG	p.R894W	PPARGC1B_uc003lrb.1_Missense_Mutation_p.R894W|PPARGC1B_uc003lrd.2_Missense_Mutation_p.R855W|PPARGC1B_uc003lrf.2_Missense_Mutation_p.R873W|PPARGC1B_uc003lre.1_Missense_Mutation_p.R873W	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	894					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CAGGAAGCGGCGGGAAAAGGC	0.577													T	149219665	T	T	149219665	3	4	164	1	0	0	0	0	1	0	0	0	12301	759	27	1	2721	1	PPARGC1B	5	149219665	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	8484306	149219665	31695595	26	11668											
NRN1	51299	broad.mit.edu	37	chr6	5999377	5999377	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agtttatcccacatatctttCgccccttcctggcaatccgt	5	15	1	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr6:5999377C>T	uc003mwu.2	-	3	912	c.261G>A	c.(259-261)GCG>GCA	p.A87A	NRN1_uc003mwt.2_Silent_p.A113A	NM_016588	NP_057672	Q9NPD7	NRN1_HUMAN	neuritin precursor	87						anchored to membrane|plasma membrane					0	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)		ACATATCTTTCGCCCCTTCCT	0.527													T	5999377	T	T	5999377	2	4	164	1	0	0	0	0	0	0	0	1	10658	871	31	2		2	NRN1	6	5999377	Silent	SNP	C	TCGA-19-5951-01A-11D-1696-08		5999377	165115690	27	11669											
DSP	1832	broad.mit.edu	37	chr6	7584664	7584664	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatcgtttaccagttgacaTagcatataagaggggctatt	9	8	0	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr6:7584664T>C	uc003mxp.1	+	24	7448	c.7169T>C	c.(7168-7170)ATA>ACA	p.I2390T	DSP_uc003mxq.1_Missense_Mutation_p.I1791T	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2390	Plectin 10.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CCAGTTGACATAGCATATAAG	0.443													C	7584664	C	C	7584664	3	2	164	1	0	0	0	0	1	0	0	0	4781	1406	49	4	7263	4	DSP	6	7584664	Missense_Mutation	SNP	T	TCGA-19-5951-01A-11D-1696-08	1585287	7584664	163530403	28	11670											
GPR146	115330	broad.mit.edu	37	chr7	1098107	1098107	+	Frame_Shift_Del	DEL	G	-	-													aaagctgccctgcggggaccGgcactgctccccggaccaca					rs147446123		TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr7:1098107delG	uc003sjw.2	+	2	1032	c.956delG	c.(955-957)CGGfs	p.R319fs	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPR146_uc003sjx.3_Frame_Shift_Del_p.R319fs|GPR146_uc003sjy.1_Frame_Shift_Del_p.R319fs	NM_138445	NP_612454	Q96CH1	GP146_HUMAN	G protein-coupled receptor 146	319	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		TGCGGGGACCGGCACTGCTCC	0.617													-	1098107	-	-	1098107	7	5	164	1	0	1	0	1	0	0	0	0	6652	1116	39	0	958	0	GPR146	7	1098107	Frame_Shift_Del	DEL	G	TCGA-19-5951-01A-11D-1696-08		1098107	158040556	29	11671											
PDE1C	5137	broad.mit.edu	37	chr7	31855673	31855673	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctcagctttgccagatgCgccttcttcagcctggcttt	8	13	3	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr7:31855673C>T	uc003tcm.1	-	15	2147	c.1678G>A	c.(1678-1680)GCA>ACA	p.A560T	PDE1C_uc003tcn.1_Missense_Mutation_p.A560T|PDE1C_uc003tco.1_Missense_Mutation_p.A620T|PDE1C_uc003tcr.2_Missense_Mutation_p.A560T|PDE1C_uc003tcs.2_Missense_Mutation_p.A560T	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	560					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TTGCCAGATGCGCCTTCTTCA	0.502													T	31855673	T	T	31855673	3	4	164	1	0	0	0	0	1	0	0	0	11635	768	27	1	238	1	PDE1C	7	31855673	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	30757566	31855673	127282990	30	11672											
CD36	948	broad.mit.edu	37	chr7	80295787	80295787	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctattgggaaagtcactgcGacatgattaatggtacaggt	11	7	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr7:80295787G>A	uc003uhc.2	+	11	1414	c.730G>A	c.(730-732)GAC>AAC	p.D244N	CD36_uc003uhd.3_Missense_Mutation_p.D244N|CD36_uc011kgv.1_Missense_Mutation_p.D168N|CD36_uc003uhe.3_Missense_Mutation_p.D244N|CD36_uc003uhf.3_Missense_Mutation_p.D244N|CD36_uc003uhg.3_Missense_Mutation_p.D244N|CD36_uc003uhh.3_Missense_Mutation_p.D244N	NM_001127444	NP_001120916	P16671	CD36_HUMAN	CD36 antigen	244	Extracellular (Potential).				cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			ovary(1)	1						AAGTCACTGCGACATGATTAA	0.348													A	80295787	A	A	80295787	3	1	164	1	0	0	0	0	1	0	0	0	3007	1058	37	2	752	2	CD36	7	80295787	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	48440114	80295787	78842876	31	11673											
SLC26A4	5172	broad.mit.edu	37	chr7	107303838	107303838	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaatggctgcttagtgacGtcatttcgggagttagtact	13	6	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr7:107303838G>A	uc003vep.2	+	3	486	c.262G>A	c.(262-264)GTC>ATC	p.V88I	LOC286002_uc003veo.3_5'Flank	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	88	Helical; (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						GCTTAGTGACGTCATTTCGGG	0.502									Pendred_syndrome				A	107303838	A	A	107303838	3	1	164	1	0	0	0	0	1	0	0	0	14519	1145	40	1	268	1	SLC26A4	7	107303838	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	27008051	107303838	51834825	32	11674											
WDR91	29062	broad.mit.edu	37	chr7	134874110	134874110	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcataccaaacagccggatgAcgccatcagctgcccctgtg	10	15	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr7:134874110A>G	uc003vsp.2	-	12	1816	c.1754T>C	c.(1753-1755)GTC>GCC	p.V585A	WDR91_uc010lmq.2_Missense_Mutation_p.V174A|WDR91_uc010lmr.2_RNA	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	585	WD 4.									breast(2)|ovary(1)|skin(1)	4						CAGCCGGATGACGCCATCAGC	0.488													G	134874110	G	G	134874110	3	3	164	1	0	0	0	0	1	0	0	0	17335	275	10	4	505	4	WDR91	7	134874110	Missense_Mutation	SNP	A	TCGA-19-5951-01A-11D-1696-08	27570272	134874110	24264553	33	11675											
OR2F2	135948	broad.mit.edu	37	chr7	143632553	143632553	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgtctcctatgccacaagCgtagtcccccagctgctggc	10	15	1	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr7:143632553C>T	uc011ktv.1	+	1	228	c.228C>T	c.(226-228)AGC>AGT	p.S76S		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					ATGCCACAAGCGTAGTCCCCC	0.517													T	143632553	T	T	143632553	2	4	164	1	0	0	0	0	0	0	0	1	10997	767	27	1		1	OR2F2	7	143632553	Silent	SNP	C	TCGA-19-5951-01A-11D-1696-08	8758443	143632553	15506110	34	11676											
NOBOX	135935	broad.mit.edu	37	chr7	144098293	144098293	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacccacagggcactgggttGtgtgtggcacgggctgagtt	17	9	0	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr7:144098293G>T	uc011kue.1	-	4	690	c.690C>A	c.(688-690)CAC>CAA	p.H230Q		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	230					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					GCACTGGGTTGTGTGTGGCAC	0.617													T	144098293	T	T	144098293	3	4	164	1	0	0	0	0	1	0	0	0	10512	1368	48	5	1317	5	NOBOX	7	144098293	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	465740	144098293	15040370	35	11677											
DOCK5	80005	broad.mit.edu	37	chr8	25246735	25246735	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggggaagacatcaagtcGtcccccaagcagtgtatcct	10	13	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr8:25246735G>A	uc003xeg.2	+	41	4397	c.4260G>A	c.(4258-4260)TCG>TCA	p.S1420S	PPP2R2A_uc003xek.2_Silent_p.S209S|DOCK5_uc003xei.2_Silent_p.S990S|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1420	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		ACATCAAGTCGTCCCCCAAGC	0.567													A	25246735	A	A	25246735	2	1	164	1	0	0	0	0	0	0	0	1	4690	1132	40	1		1	DOCK5	8	25246735	Silent	SNP	G	TCGA-19-5951-01A-11D-1696-08		25246735	121117287	36	11678											
BRF2	55290	broad.mit.edu	37	chr8	37704528	37704528	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttaggggccagttatgctgtCggcaggtgattaagacgcag	15	7	0	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr8:37704528C>T	uc003xkk.2	-	3	490	c.380G>A	c.(379-381)CGA>CAA	p.R127Q		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	127	1.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			GTTATGCTGTCGGCAGGTGAT	0.527													T	37704528	T	T	37704528	3	4	164	1	0	0	0	0	1	0	0	0	1511	884	31	2	887	2	BRF2	8	37704528	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	12457793	37704528	108659494	37	11679											
SOX17	64321	broad.mit.edu	37	chr8	55371633	55371633	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaggcaagtcgtggaaggCgctgacgctggcggagaagc	18	9	0	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr8:55371633C>T	uc003xsb.3	+	2	527	c.323C>T	c.(322-324)GCG>GTG	p.A108V		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	108	HMG box.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			TCGTGGAAGGCGCTGACGCTG	0.701													T	55371633	T	T	55371633	3	4	164	1	0	0	0	0	1	0	0	0	14947	768	27	1	329	1	SOX17	8	55371633	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	17667105	55371633	90992389	38	11680											
WDR67	93594	broad.mit.edu	37	chr8	124113069	124113069	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttggagtactaagtcaagAtggtattatgagatttatca	9	4	3	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr8:124113069A>G	uc003ypp.1	+	7	944	c.854A>G	c.(853-855)GAT>GGT	p.D285G	WDR67_uc011lig.1_Missense_Mutation_p.D285G|WDR67_uc011lih.1_Missense_Mutation_p.D175G|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_5'UTR|WDR67_uc003ypo.1_Missense_Mutation_p.D285G|WDR67_uc003ypr.2_RNA	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	285						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			CTAAGTCAAGATGGTATTATG	0.353													G	124113069	G	G	124113069	3	3	164	1	0	0	0	0	1	0	0	0	17315	333	12	4	880	4	WDR67	8	124113069	Missense_Mutation	SNP	A	TCGA-19-5951-01A-11D-1696-08	68741436	124113069	22250953	39	11681											
ADCY8	114	broad.mit.edu	37	chr8	131896832	131896832	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctccaggctggagtctTtaaacatcagtgagaatggc	12	8	2	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr8:131896832T>G	uc003ytd.3	-	8	2343	c.2087A>C	c.(2086-2088)AAA>ACA	p.K696T	ADCY8_uc010mds.2_Missense_Mutation_p.K696T	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	696	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GCTGGAGTCTTTAAACATCAG	0.468										HNSCC(32;0.087)			G	131896832	G	G	131896832	3	3	164	1	0	0	0	0	1	0	0	0	300	1841	64	5	1712	5	ADCY8	8	131896832	Missense_Mutation	SNP	T	TCGA-19-5951-01A-11D-1696-08	7783763	131896832	14467190	40	11682											
KIF24	347240	broad.mit.edu	37	chr9	34257897	34257897	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccaggggagctctgaattcGttttggagaggagtttccag	14	8	1	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr9:34257897G>A	uc003zua.3	-	11	1828	c.1708C>T	c.(1708-1710)CGA>TGA	p.R570*	KIF24_uc010mkb.2_Intron	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	570					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			CTCTGAATTCGTTTTGGAGAG	0.448													A	34257897	A	A	34257897	4	1	164	1	0	0	0	0	0	1	0	0	8292	1153	40	1	2410	1	KIF24	9	34257897	Nonsense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08		34257897	106955534	41	11683											
COL15A1	1306	broad.mit.edu	37	chr9	101810265	101810265	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tcaagggtaccaaaggagatCcaggggtcattatgcaggtg	14	7	2	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr9:101810265C>A	uc004azb.1	+	28	2982	c.2776C>A	c.(2776-2778)CCA>ACA	p.P926T		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	926	Triple-helical region 5 (COL5).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				CAAAGGAGATCCAGGGGTCAT	0.617													A	101810265	A	A	101810265	3	1	164	1	0	0	0	0	1	0	0	0	3672	855	30	5	2886	5	COL15A1	9	101810265	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	67552368	101810265	39403166	42	11684											
C9orf86	55684	broad.mit.edu	37	chr9	139726289	139726289	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcctgccggacgacgtgcGtgacttcatcgacaacctgg	11	14	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr9:139726289G>A	uc004cji.1	+	6	843	c.575G>A	c.(574-576)CGT>CAT	p.R192H	C9orf86_uc004cjm.2_Missense_Mutation_p.R192H|C9orf86_uc004cjh.2_Missense_Mutation_p.R192H|C9orf86_uc004cjj.1_Missense_Mutation_p.R192H|C9orf86_uc004cjk.1_RNA|C9orf86_uc010nbr.1_Missense_Mutation_p.R192H|C9orf86_uc004cjl.1_RNA|C9orf86_uc010nbs.1_Missense_Mutation_p.R77H	NM_024718	NP_078994	Q3YEC7	PARF_HUMAN	Rab-like GTP-binding protein 1 isoform 1	192	Small GTPase-like.				small GTPase mediated signal transduction	cytoplasm|nucleus	GTP binding|protein binding				0	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.61e-05)|Epithelial(140;0.000183)		GACGACGTGCGTGACTTCATC	0.677													A	139726289	A	A	139726289	3	1	164	1	0	0	0	0	1	0	0	0	2502	1145	40	1	597	1	C9orf86	9	139726289	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	37916024	139726289	1487142	43	11685											
OR51A7	119687	broad.mit.edu	37	chr11	4929295	4929295	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	agcattgcatctttggcagaGaggcttaaggccctaaatac	10	9	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr11:4929295G>T	uc010qyq.1	+	1	696	c.696G>T	c.(694-696)GAG>GAT	p.E232D		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTTGGCAGAGAGGCTTAAGG	0.478													T	4929295	T	T	4929295	3	4	164	1	0	0	0	0	1	0	0	0	11088	933	33	5	698	5	OR51A7	11	4929295	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08		4929295	130077221	44	11686											
OR52B6	340980	broad.mit.edu	37	chr11	5602633	5602633	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccacagcttcatcattatgtTtccatccatctttctccttg	3	14	4	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr11:5602633T>A	uc010qzi.1	+	1	527	c.527T>A	c.(526-528)TTT>TAT	p.F176Y	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	176	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCATTATGTTTCCATCCATC	0.498													A	5602633	A	A	5602633	3	1	164	1	0	0	0	0	1	0	0	0	11113	1841	64	5	529	5	OR52B6	11	5602633	Missense_Mutation	SNP	T	TCGA-19-5951-01A-11D-1696-08	673338	5602633	129403883	45	11687											
PIK3C2A	5286	broad.mit.edu	37	chr11	17111388	17111388	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacccaagaaaaaattctccCgcagagattctgcactgagt	7	12	2	3			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr11:17111388C>T	uc001mmq.3	-	32	5024	c.4958G>A	c.(4957-4959)CGG>CAG	p.R1653Q	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.R1273Q|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1653	C2.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	AAAATTCTCCCGCAGAGATTC	0.413													T	17111388	T	T	17111388	3	4	164	1	0	0	0	0	1	0	0	0	11909	652	23	2	106	2	PIK3C2A	11	17111388	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	11508755	17111388	117895128	46	11688											
MS4A14	84689	broad.mit.edu	37	chr11	60184370	60184370	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaaaactgttatgccaagaTtcagaatcccaaatacagca	5	11	1	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr11:60184370T>C	uc001npj.2	+	5	2494	c.1929T>C	c.(1927-1929)GAT>GAC	p.D643D	MS4A14_uc001npi.2_Silent_p.D531D|MS4A14_uc001npn.2_Silent_p.D381D|MS4A14_uc001npk.2_Silent_p.D626D|MS4A14_uc001npl.2_Silent_p.D381D|MS4A14_uc001npm.2_Silent_p.D381D	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	643	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						TATGCCAAGATTCAGAATCCC	0.473													C	60184370	C	C	60184370	2	2	164	1	0	0	0	0	0	0	0	1	9858	1490	52	4		4	MS4A14	11	60184370	Silent	SNP	T	TCGA-19-5951-01A-11D-1696-08	43072982	60184370	74822146	47	11689											
RBM4	5936	broad.mit.edu	37	chr11	66411465	66411465	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcgctacagccccagtcccCactgttggagagggctacgg	13	15	0	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr11:66411465C>T	uc009yrj.2	+	3	1445	c.957C>T	c.(955-957)CCC>CCT	p.P319P	RBM4_uc009yrk.2_Silent_p.P294P|RBM4_uc001oiw.1_Silent_p.P319P|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_Silent_p.P319P|RBM4_uc001oiz.1_Silent_p.P319P	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	319	Interaction with TNPO3.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		CCCCAGTCCCCACTGTTGGAG	0.493													T	66411465	T	T	66411465	2	4	164	1	0	0	0	0	0	0	0	1	13134	581	21	3		3	RBM4	11	66411465	Silent	SNP	C	TCGA-19-5951-01A-11D-1696-08	6227095	66411465	68595051	48	11690											
POU2AF1	5450	broad.mit.edu	37	chr11	111229596	111229596	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactggctccttcacacggaCgccctggtatggccgggccg	13	16	1	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr11:111229596C>T	uc001plg.3	-	2	319	c.64G>A	c.(64-66)GTC>ATC	p.V22I		NM_006235	NP_006226	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	22					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			kidney(1)	1		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		TTCACACGGACGCCCTGGTAT	0.627			T	BCL6	NHL								T	111229596	T	T	111229596	3	4	164	1	0	0	0	0	1	0	0	0	12270	536	19	1	722	1	POU2AF1	11	111229596	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	44818131	111229596	23776920	49	11691											
CD3E	916	broad.mit.edu	37	chr11	118183512	118183512	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagaattggagcaaagtggtTattatgtctgctaccccaga	10	8	1	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr11:118183512T>C	uc001psq.3	+	6	539	c.283T>C	c.(283-285)TAT>CAT	p.Y95H	CD3E_uc010rya.1_Missense_Mutation_p.Y95H	NM_000733	NP_000724	P07766	CD3E_HUMAN	CD3E antigen, epsilon polypeptide precursor	95	Extracellular (Potential).|Ig-like.				G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			ovary(2)	2	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	GCAAAGTGGTTATTATGTCTG	0.443													C	118183512	C	C	118183512	3	2	164	1	0	0	0	0	1	0	0	0	3011	1754	61	4	301	4	CD3E	11	118183512	Missense_Mutation	SNP	T	TCGA-19-5951-01A-11D-1696-08	6953916	118183512	16823004	50	11692											
MFRP	83552	broad.mit.edu	37	chr11	119215663	119215663	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcagagacgaagaccaccagGaggtggctggcattggtgtt	15	8	1	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr11:119215663G>A	uc001pwj.2	-	6	853	c.693C>T	c.(691-693)CTC>CTT	p.L231L	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Silent_p.L231L	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		AGACCACCAGGAGGTGGCTGG	0.617													A	119215663	A	A	119215663	2	1	164	1	0	0	0	0	0	0	0	1	9526	1161	41	3		3	MFRP	11	119215663	Silent	SNP	G	TCGA-19-5951-01A-11D-1696-08	1032151	119215663	15790853	51	11693											
OR10G7	390265	broad.mit.edu	37	chr11	123909127	123909127	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcacaaagatgaccatctcGttggctgaggtgtctgcaca	10	10	3	3	rs147011748	byFrequency	TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr11:123909127G>A	uc001pzq.1	-	1	582	c.582C>T	c.(580-582)AAC>AAT	p.N194N		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGACCATCTCGTTGGCTGAGG	0.537													A	123909127	A	A	123909127	2	1	164	1	0	0	0	0	0	0	0	1	10902	1136	40	1		1	OR10G7	11	123909127	Silent	SNP	G	TCGA-19-5951-01A-11D-1696-08	4693464	123909127	11097389	52	11694											
ACSM4	341392	broad.mit.edu	37	chr12	7456944	7456944	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaccatgaagatttttttccGctaccagacatttagattca	5	9	1	4			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr12:7456944G>A	uc001qsx.1	+	1	17	c.17G>A	c.(16-18)CGC>CAC	p.R6H		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	6					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						ATTTTTTTCCGCTACCAGACA	0.468													A	7456944	A	A	7456944	3	1	164	1	0	0	0	0	1	0	0	0	186	1087	38	1	19	1	ACSM4	12	7456944	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08		7456944	126394951	53	11695											
SLCO1B3	28234	broad.mit.edu	37	chr12	21036410	21036410	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagaacagaaattactcagCacacttgggtgaatgcccaa	8	11	1	3			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr12:21036410C>T	uc001rek.2	+	12	1682	c.1556C>T	c.(1555-1557)GCA>GTA	p.A519V	SLCO1B3_uc001rel.2_Missense_Mutation_p.A519V|SLCO1B3_uc010sil.1_Missense_Mutation_p.A519V|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.A344V	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	519	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					AATTACTCAGCACACTTGGGT	0.338													T	21036410	T	T	21036410	3	4	164	1	0	0	0	0	1	0	0	0	14724	710	25	3	1598	3	SLCO1B3	12	21036410	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	13579466	21036410	112815485	54	11696											
ABCC9	10060	broad.mit.edu	37	chr12	21997448	21997448	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tattagtatcagctgaaaagCgattgagaatcagtcccagg	10	7	2	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr12:21997448C>T	uc001rfi.1	-	26	3304	c.3284G>A	c.(3283-3285)CGC>CAC	p.R1095H	ABCC9_uc001rfh.2_Missense_Mutation_p.R1095H|ABCC9_uc001rfj.1_Missense_Mutation_p.R1059H	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1095	ABC transmembrane type-1 2.|Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGCTGAAAAGCGATTGAGAAT	0.353													T	21997448	T	T	21997448	3	4	164	1	0	0	0	0	1	0	0	0	59	768	27	1	1559	1	ABCC9	12	21997448	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	961038	21997448	111854447	55	11697											
STK38L	23012	broad.mit.edu	37	chr12	27467499	27467499	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagaggaaacacagttctacAtttcagagactgttctggca	9	8	3	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr12:27467499A>G	uc001rhr.2	+	7	779	c.580A>G	c.(580-582)ATT>GTT	p.I194V	STK38L_uc001rhs.2_RNA|STK38L_uc010sjm.1_Missense_Mutation_p.I101V|STK38L_uc010sjn.1_5'UTR	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	194	Protein kinase.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|kidney(1)	5	Colorectal(261;0.0847)					ACAGTTCTACATTTCAGAGAC	0.378													G	27467499	G	G	27467499	3	3	164	1	0	0	0	0	1	0	0	0	15303	217	8	4	602	4	STK38L	12	27467499	Missense_Mutation	SNP	A	TCGA-19-5951-01A-11D-1696-08	5470051	27467499	106384396	56	11698											
CACNB3	784	broad.mit.edu	37	chr12	49218455	49218455	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctccctttcttctcaggagAtctgggaacccttccagcct	7	16	3	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr12:49218455A>G	uc001rsl.1	+	5	612	c.411A>G	c.(409-411)AGA>AGG	p.R137R	CACNB3_uc010slx.1_Silent_p.R124R|CACNB3_uc010sly.1_Silent_p.R124R|CACNB3_uc010slz.1_Silent_p.R136R|CACNB3_uc001rsk.1_5'UTR	NM_000725	NP_000716	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3	137					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0					Verapamil(DB00661)	TTCTCAGGAGATCTGGGAACC	0.483													G	49218455	G	G	49218455	2	3	164	1	0	0	0	0	0	0	0	1	2554	330	12	4		4	CACNB3	12	49218455	Silent	SNP	A	TCGA-19-5951-01A-11D-1696-08	21750956	49218455	84633440	57	11699											
RNF17	56163	broad.mit.edu	37	chr13	25444863	25444863	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaggcgcttcctcctctgaCggattttagaacaggtatac	10	10	1	3			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr13:25444863C>T	uc001upr.2	+	32	4474	c.4433C>T	c.(4432-4434)ACG>ATG	p.T1478M	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.T1474M|RNF17_uc001ups.2_Missense_Mutation_p.T1417M|RNF17_uc010aac.2_Missense_Mutation_p.T670M|RNF17_uc010aad.2_Missense_Mutation_p.T488M	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1478					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CCTCCTCTGACGGATTTTAGA	0.423													T	25444863	T	T	25444863	3	4	164	1	0	0	0	0	1	0	0	0	13461	536	19	1	4559	1	RNF17	13	25444863	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08		25444863	89725015	58	11700											
PCDH20	64881	broad.mit.edu	37	chr13	61985634	61985634	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagatttgtggttctttctcCtctatattaatctctggttc	7	8	4	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr13:61985634C>T	uc001vid.3	-	2	2962	c.2598G>A	c.(2596-2598)GAG>GAA	p.E866E	PCDH20_uc010thj.1_Silent_p.E866E	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	839	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GTTCTTTCTCCTCTATATTAA	0.393													T	61985634	T	T	61985634	2	4	164	1	0	0	0	0	0	0	0	1	11515	680	24	3		3	PCDH20	13	61985634	Silent	SNP	C	TCGA-19-5951-01A-11D-1696-08	36540771	61985634	53184244	59	11701											
OR4K17	390436	broad.mit.edu	37	chr14	20586156	20586156	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ataccatttgctgtgaacttGcccttttgtggtcccaatgt	8	10	0	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr14:20586156G>A	uc001vwo.1	+	1	591	c.591G>A	c.(589-591)TTG>TTA	p.L197L		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTGTGAACTTGCCCTTTTGTG	0.428													A	20586156	A	A	20586156	2	1	164	1	0	0	0	0	0	0	0	1	11071	1310	46	3		3	OR4K17	14	20586156	Silent	SNP	G	TCGA-19-5951-01A-11D-1696-08		20586156	86763384	60	11702											
CLEC14A	161198	broad.mit.edu	37	chr14	38724256	38724256	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtgtctctcccagcttctcGtcgaccctgattggccatgt	10	14	2	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr14:38724256G>T	uc001wum.1	-	1	1319	c.972C>A	c.(970-972)GAC>GAA	p.D324E		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	324	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CCAGCTTCTCGTCGACCCTGA	0.602													T	38724256	T	T	38724256	3	4	164	1	0	0	0	0	1	0	0	0	3499	1136	40	5	504	5	CLEC14A	14	38724256	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	18138100	38724256	68625284	61	11703											
PLEKHG3	26030	broad.mit.edu	37	chr14	65208951	65208951	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggtggccccactgcaccccCgcatcgtgcagctctcccac	9	20	1	0	rs150120531	byFrequency	TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr14:65208951C>G	uc001xho.1	+	16	2985	c.2716C>G	c.(2716-2718)CGC>GGC	p.R906G	PLEKHG3_uc001xhn.1_Missense_Mutation_p.R850G|PLEKHG3_uc001xhp.2_Missense_Mutation_p.R1027G|PLEKHG3_uc010aqh.1_Missense_Mutation_p.R448G|PLEKHG3_uc001xhq.1_Missense_Mutation_p.R411G	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	906					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		ACTGCACCCCCGCATCGTGCA	0.662													G	65208951	G	G	65208951	3	3	164	1	0	0	0	0	1	0	0	0	12070	652	23	5	2598	5	PLEKHG3	14	65208951	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	26484695	65208951	42140589	62	11704											
AK7	122481	broad.mit.edu	37	chr14	96864516	96864516	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctggaagcttcctcaaccaaAgtgaaggaaggcacattcca	9	11	1	1	rs17853407		TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr14:96864516A>T	uc001yfn.2	+	2	254	c.210A>T	c.(208-210)AAA>AAT	p.K70N	AK7_uc001yfm.1_Missense_Mutation_p.K70N	NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	70	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CCTCAACCAAAGTGAAGGAAG	0.507													T	96864516	T	T	96864516	3	4	164	1	0	0	0	0	1	0	0	0	444	69	3	5	216	5	AK7	14	96864516	Missense_Mutation	SNP	A	TCGA-19-5951-01A-11D-1696-08	31655565	96864516	10485024	63	11705											
JAG2	3714	broad.mit.edu	37	chr14	105609273	105609273	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcgcctcgtccgccctgCgcggcggcggcgtgaagttc	16	16	0	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr14:105609273C>T	uc001yqg.2	-	26	3880	c.3476G>A	c.(3475-3477)CGC>CAC	p.R1159H	JAG2_uc010axf.2_5'UTR|JAG2_uc001yqf.2_Missense_Mutation_p.R563H|JAG2_uc001yqh.2_Missense_Mutation_p.R1121H	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1159	Cytoplasmic (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		gtccgccctgcgcggcggcgg	0.463													T	105609273	T	T	105609273	3	4	164	1	0	0	0	0	1	0	0	0	7935	768	27	1	244	1	JAG2	14	105609273	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	8744757	105609273	1740267	64	11706											
PIF1	80119	broad.mit.edu	37	chr15	65110455	65110455	+	Splice_Site	DEL	C	-	-													ccacctcctcccaacacttaCctctcccttctgcctcgaac							TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr15:65110455delC	uc002ant.2	-	10	1594	c.1528_splice	c.e10+1	p.G510_splice	PIF1_uc002anr.2_Splice_Site_p.G58_splice|PIF1_uc002ans.2_Splice_Site_p.G201_splice|PIF1_uc010uiq.1_Splice_Site_p.G510_splice	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	DNA helicase homolog PIF1						negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0						CCAACACTTACCTCTCCCTTC	0.582													-	65110455	-	-	65110455	8	5	164	1	0	1	0	1	0	0	1	0	11883	521	18	0	412	0	PIF1	15	65110455	Splice_Site	DEL	C	TCGA-19-5951-01A-11D-1696-08		65110455	37420937	65	11707											
LRRK1	79705	broad.mit.edu	37	chr15	101595366	101595366	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccatgagggcgccctaggcGtggagggcactcctggctac	15	13	0	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr15:101595366G>A	uc002bwr.2	+	27	4589	c.4270G>A	c.(4270-4272)GTG>ATG	p.V1424M	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1424	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CGCCCTAGGCGTGGAGGGCAC	0.567													A	101595366	A	A	101595366	3	1	164	1	0	0	0	0	1	0	0	0	9032	1145	40	1	4372	1	LRRK1	15	101595366	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	36484911	101595366	936026	66	11708											
APOB48R	55911	broad.mit.edu	37	chr16	28507939	28507939	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttggaggcaactccagaggCcaggcctgaggaggagctca	15	11	1	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr16:28507939C>T	uc002dqb.1	+	3	1560	c.1550C>T	c.(1549-1551)GCC>GTC	p.A517V	uc010vct.1_Intron|APOB48R_uc010byg.1_Missense_Mutation_p.A55V	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	517	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						ACTCCAGAGGCCAGGCCTGAG	0.652													T	28507939	T	T	28507939	3	4	164	1	0	0	0	0	1	0	0	0	786	739	26	3	1560	3	APOB48R	16	28507939	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08		28507939	61846814	67	11709											
SLC5A2	6524	broad.mit.edu	37	chr16	31500623	31500623	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctggcctcctcaccctcacGgtctccctgtgcaccgcgcc	8	21	4	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr16:31500623G>A	uc002ecf.3	+	12	1648	c.1629G>A	c.(1627-1629)ACG>ACA	p.T543T	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	543	Helical; (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						TCACCCTCACGGTCTCCCTGT	0.637													A	31500623	A	A	31500623	2	1	164	1	0	0	0	0	0	0	0	1	14665	1103	39	2		2	SLC5A2	16	31500623	Silent	SNP	G	TCGA-19-5951-01A-11D-1696-08	2992684	31500623	58854130	68	11710											
NOL3	8996	broad.mit.edu	37	chr16	67208819	67208819	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggacccagagcccgagccCgacttcgaggaaagggacga	14	14	0	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr16:67208819C>T	uc010vjd.1	+	3	774	c.767C>T	c.(766-768)CCG>CTG	p.P256L	NOL3_uc010vjc.1_Silent_p.P259P|NOL3_uc002erp.2_Silent_p.P197P			O60936	NOL3_HUMAN	RecName: Full=Nucleolar protein 3; AltName: Full=Apoptosis repressor with CARD; AltName: Full=Muscle-enriched cytoplasmic protein;          Short=Myp; AltName: Full=Nucleolar protein of 30 kDa;          Short=Nop30;	194					anti-apoptosis|apoptosis|mRNA processing|RNA splicing	cytosol|nucleolus	identical protein binding|RNA binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		agcccgagcccgacttcgaGG	0.323													T	67208819	T	T	67208819	3	4	164	1	0	0	0	0	1	0	0	0	10523	652	23	2	597	2	NOL3	16	67208819	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	35708196	67208819	23145934	69	11711											
FOXL1	2300	broad.mit.edu	37	chr16	86613224	86613224	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctgggtgcctcgctcctgGccgcctcctccagcctccgt	11	19	1	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr16:86613224G>A	uc002fjr.2	+	1	1110	c.895G>A	c.(895-897)GCC>ACC	p.A299T		NM_005250	NP_005241	Q12952	FOXL1_HUMAN	forkhead box L1	299					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1						CTCGCTCCTGGCCGCCTCCTC	0.672													A	86613224	A	A	86613224	3	1	164	1	0	0	0	0	1	0	0	0	6016	1203	42	3	897	3	FOXL1	16	86613224	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	19404405	86613224	3741529	70	11712											
TRPV1	7442	broad.mit.edu	37	chr17	3493599	3493599	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaagaagtccccatgggccGcagcctggacgtctgctccg	12	14	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr17:3493599G>A	uc010vrr.1	-	4	1219	c.692C>T	c.(691-693)GCG>GTG	p.A231V	TRPV1_uc010vro.1_Missense_Mutation_p.A231V|TRPV1_uc010vrp.1_Missense_Mutation_p.A231V|TRPV1_uc010vrq.1_Missense_Mutation_p.A229V|TRPV1_uc010vrs.1_Missense_Mutation_p.A231V|TRPV1_uc010vrt.1_Missense_Mutation_p.A231V|TRPV1_uc010vru.1_Missense_Mutation_p.A231V	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	231	ANK 3.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	CCCATGGGCCGCAGCCTGGAC	0.572													A	3493599	A	A	3493599	3	1	164	1	0	0	0	0	1	0	0	0	16592	1087	38	1	1548	1	TRPV1	17	3493599	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08		3493599	77701611	71	11713											
POTEC	388468	broad.mit.edu	37	chr18	14542809	14542809	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgcccacgttgctcttgcCgctccccctgcagcagggga	12	17	1	0	rs113041483		TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr18:14542809C>T	uc010dln.2	-	1	791	c.337G>A	c.(337-339)GGC>AGC	p.G113S	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	113										skin(3)	3						TTGCTCTTGCCGCTCCCCCTG	0.597													T	14542809	T	T	14542809	3	4	164	1	0	0	0	0	1	0	0	0	12262	652	23	2	1335	2	POTEC	18	14542809	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08		14542809	63534439	72	11714											
ABCA7	10347	broad.mit.edu	37	chr19	1056425	1056425	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgcccccaggcccggccCgccacgcccacagcatcacc	8	24	1	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr19:1056425C>T	uc002lqw.3	+	33	4744	c.4513C>T	c.(4513-4515)CGC>TGC	p.R1505C	ABCA7_uc002lqy.2_5'Flank|ABCA7_uc010dsc.2_5'Flank	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1505	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGCCCGGCCCGCCACGCCCA	0.612													T	1056425	T	T	1056425	3	4	164	1	0	0	0	0	1	0	0	0	37	652	23	2	4639	2	ABCA7	19	1056425	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08		1056425	58072558	73	11715											
EMR1	2015	broad.mit.edu	37	chr19	6906478	6906478	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaaggaagatgtgataccCgataataagcagatccagca	10	7	0	3			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr19:6906478C>T	uc002mfw.2	+	9	1022	c.984C>T	c.(982-984)CCC>CCT	p.P328P	EMR1_uc010dvc.2_Silent_p.P328P|EMR1_uc010dvb.2_Silent_p.P276P|EMR1_uc010xji.1_Silent_p.P187P|EMR1_uc010xjj.1_Silent_p.P151P	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	328	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					ATGTGATACCCGATAATAAGC	0.388													T	6906478	T	T	6906478	2	4	164	1	0	0	0	0	0	0	0	1	5104	639	23	2		2	EMR1	19	6906478	Silent	SNP	C	TCGA-19-5951-01A-11D-1696-08	5850053	6906478	52222505	74	11716											
RAVER1	125950	broad.mit.edu	37	chr19	10434234	10434234	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagctgcccatcctggccGcacgccagctgccggaggaa	12	16	1	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr19:10434234G>A	uc002moa.2	-	4	896	c.816C>T	c.(814-816)TGC>TGT	p.C272C		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	255	RRM 3.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CATCCTGGCCGCACGCCAGCT	0.667													A	10434234	A	A	10434234	2	1	164	1	0	0	0	0	0	0	0	1	13094	1079	38	1		1	RAVER1	19	10434234	Silent	SNP	G	TCGA-19-5951-01A-11D-1696-08	3527756	10434234	48694749	75	11717											
ZNF676	163223	broad.mit.edu	37	chr19	22364159	22364159	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttgaacatttatgaaagacGtttgcatatttgccacattg	7	6	0	3			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr19:22364159G>C	uc002nqs.1	-	3	678	c.360C>G	c.(358-360)AAC>AAG	p.N120K		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TATGAAAGACGTTTGCATATT	0.328													C	22364159	C	C	22364159	3	2	164	1	0	0	0	0	1	0	0	0	18080	1136	40	5	1410	5	ZNF676	19	22364159	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	11929925	22364159	36764824	76	11718											
PSG7	5676	broad.mit.edu	37	chr19	43441294	43441294	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccagaatcttcctgagcaCggctgtcagctgtgctgtcc	10	13	2	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr19:43441294C>T	uc002ovl.3	-	1	37	c.-65G>A	c.(-67--63)CCGTG>CCATG		PSG3_uc002ouf.2_5'Flank|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Translation_Start_Site	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7						female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTCCTGAGCACGGCTGTCAGC	0.617													T	43441294	T	T	43441294	1	4	164	1	0	0	0	0	0	0	0	0	12660	551	19	1		1	PSG7	19	43441294	Translation_Start_Site	SNP	C	TCGA-19-5951-01A-11D-1696-08	21077135	43441294	15687689	77	11719											
C5AR1	728	broad.mit.edu	37	chr19	47823567	47823567	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcctgtaccgggtggtccGggaggagtactttccaccaa	12	12	0	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr19:47823567G>A	uc002pgj.1	+	2	582	c.533G>A	c.(532-534)CGG>CAG	p.R178Q		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	178	Extracellular (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CGGGTGGTCCGGGAGGAGTAC	0.637													A	47823567	A	A	47823567	3	1	164	1	0	0	0	0	1	0	0	0	2281	1116	39	2	538	2	C5AR1	19	47823567	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	4382273	47823567	11305416	78	11720											
POLD1	5424	broad.mit.edu	37	chr19	50918754	50918754	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcggacctgctgtgcaaccGcatcgatatctcccagctgg	10	15	1	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr19:50918754G>A	uc002psb.3	+	21	2680	c.2624G>A	c.(2623-2625)CGC>CAC	p.R875H	POLD1_uc002psc.3_Missense_Mutation_p.R875H|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.R901H	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	875					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CTGTGCAACCGCATCGATATC	0.657								DNA_polymerases_(catalytic_subunits)					A	50918754	A	A	50918754	3	1	164	1	0	0	0	0	1	0	0	0	12190	1087	38	1	2702	1	POLD1	19	50918754	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	3095187	50918754	8210229	79	11721											
SNX5	27131	broad.mit.edu	37	chr20	17929612	17929612	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatctgatgaaactcgaccCtctactttctatatagaaaa	4	10	4	3			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr20:17929612C>T	uc002wqc.2	-	10	926	c.840G>A	c.(838-840)GAG>GAA	p.E280E	SNX5_uc002wqb.2_RNA|SNX5_uc002wqd.2_Silent_p.E280E|SNX5_uc002wqe.2_Silent_p.E175E|SNX5_uc010zrt.1_Silent_p.E280E	NM_014426	NP_055241	Q9Y5X3	SNX5_HUMAN	sorting nexin 5	280	BAR.				cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			large_intestine(1)	1						AAACTCGACCCTCTACTTTCT	0.383													T	17929612	T	T	17929612	2	4	164	1	0	0	0	0	0	0	0	1	14905	680	24	3		3	SNX5	20	17929612	Silent	SNP	C	TCGA-19-5951-01A-11D-1696-08		17929612	45095908	80	11722											
NCOA3	8202	broad.mit.edu	37	chr20	46264906	46264906	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtcaaatagcagagatcaCctcagtgacaaagaaagtaa	8	8	3	3			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr20:46264906C>T	uc002xtk.2	+	12	1981	c.1776C>T	c.(1774-1776)CAC>CAT	p.H592H	NCOA3_uc010ght.1_Silent_p.H602H|NCOA3_uc002xtl.2_Silent_p.H592H|NCOA3_uc002xtm.2_Silent_p.H592H|NCOA3_uc002xtn.2_Silent_p.H592H|NCOA3_uc010zyc.1_Silent_p.H387H	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	592	Ser-rich.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						GCAGAGATCACCTCAGTGACA	0.423													T	46264906	T	T	46264906	2	4	164	1	0	0	0	0	0	0	0	1	10230	506	18	3		3	NCOA3	20	46264906	Silent	SNP	C	TCGA-19-5951-01A-11D-1696-08	28335294	46264906	16760614	81	11723											
DSCAM	1826	broad.mit.edu	37	chr21	41455893	41455893	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaagggtgatggaggaagaCgtggtcttggagactgtaag	18	3	1	3			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chr21:41455893C>T	uc002yyq.1	-	24	4625	c.4173G>A	c.(4171-4173)ACG>ACA	p.T1391T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1391	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGAGGAAGACGTGGTCTTGG	0.433													T	41455893	T	T	41455893	2	4	164	1	0	0	0	0	0	0	0	1	4768	523	19	1		1	DSCAM	21	41455893	Silent	SNP	C	TCGA-19-5951-01A-11D-1696-08		41455893	6674002	82	11724											
ARSH	347527	broad.mit.edu	37	chrX	2931164	2931164	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggtcttcccaccaatgaaacGacttttgccaagctgctgca	8	13	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chrX:2931164G>A	uc011mhj.1	+	3	291	c.291G>A	c.(289-291)ACG>ACA	p.T97T		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	97						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CCAATGAAACGACTTTTGCCA	0.552													A	2931164	A	A	2931164	2	1	164	1	0	0	0	0	0	0	0	1	993	1045	37	2		2	ARSH	23	2931164	Silent	SNP	G	TCGA-19-5951-01A-11D-1696-08		2931164	152339396	83	11725											
ELK1	2002	broad.mit.edu	37	chrX	47496310	47496310	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagggatgtgcacctgggcgCtgccactggatggaaactgg	16	9	0	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chrX:47496310C>T	uc004dik.3	-	7	1527	c.1205G>A	c.(1204-1206)AGC>AAC	p.S402N	ELK1_uc010nhv.2_Missense_Mutation_p.S402N|ELK1_uc010nhw.2_Missense_Mutation_p.S292N|ELK1_uc004dil.3_RNA	NM_001114123	NP_001107595	P19419	ELK1_HUMAN	ELK1 protein	402					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						CACCTGGGCGCTGCCACTGGA	0.597													T	47496310	T	T	47496310	3	4	164	1	0	0	0	0	1	0	0	0	5059	797	28	3	85	3	ELK1	23	47496310	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	44565146	47496310	107774250	84	11726											
ZNF182	7569	broad.mit.edu	37	chrX	47842806	47842806	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctacatcttcaaatgtcacTagcccctgtaatggtacatt	6	11	3	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chrX:47842806T>C	uc004dir.2	-	5	424	c.78A>G	c.(76-78)CTA>CTG	p.L26L	ZNF182_uc004dis.2_Silent_p.L7L|ZNF182_uc004dit.2_Silent_p.L26L|ZNF182_uc011mlu.1_Silent_p.L7L|ZNF630_uc010nhz.1_RNA	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	26					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CAAATGTCACTAGCCCCTGTA	0.463													C	47842806	C	C	47842806	2	2	164	1	0	0	0	0	0	0	0	1	17747	1509	53	4		4	ZNF182	23	47842806	Silent	SNP	T	TCGA-19-5951-01A-11D-1696-08	346496	47842806	107427754	85	11727											
WAS	7454	broad.mit.edu	37	chrX	48545194	48545194	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccagtgggtccgctctcccTggggctggcgacagtggaca	15	13	1	0			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chrX:48545194T>G	uc004dkm.3	+	7	641	c.584T>G	c.(583-585)CTG>CGG	p.L195R		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	195					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				CCGCTCTCCCTGGGGCTGGCG	0.582			Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				G	48545194	G	G	48545194	3	3	164	1	0	0	0	0	1	0	0	0	17248	1580	55	5	610	5	WAS	23	48545194	Missense_Mutation	SNP	T	TCGA-19-5951-01A-11D-1696-08	702388	48545194	106725366	86	11728											
SHROOM4	57477	broad.mit.edu	37	chrX	50377938	50377938	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgagtgggttggaatccaCgctggaagctctgtcacagg	14	8	2	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chrX:50377938C>T	uc004dpe.2	-	4	1161	c.1135G>A	c.(1135-1137)GTG>ATG	p.V379M	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.V263M	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	379					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					TTGGAATCCACGCTGGAAGCT	0.542													T	50377938	T	T	50377938	3	4	164	1	0	0	0	0	1	0	0	0	14296	536	19	1	3370	1	SHROOM4	23	50377938	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	1832744	50377938	104892622	87	11729											
ERCC6L	54821	broad.mit.edu	37	chrX	71425657	71425657	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcacaaaccctgctctggaaTtaggtgcagagccacacaag	10	12	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chrX:71425657T>C	uc004eaq.1	-	2	3057	c.2960A>G	c.(2959-2961)AAT>AGT	p.N987S	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Missense_Mutation_p.N864S	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	987					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					TGCTCTGGAATTAGGTGCAGA	0.393													C	71425657	C	C	71425657	3	2	164	1	0	0	0	0	1	0	0	0	5218	1493	52	4	796	4	ERCC6L	23	71425657	Missense_Mutation	SNP	T	TCGA-19-5951-01A-11D-1696-08	21047719	71425657	83844903	88	11730											
AMOT	154796	broad.mit.edu	37	chrX	112025789	112025789	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgccctccatgtcaaggcaaCgcttattggccatcaagatt	8	12	2	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chrX:112025789C>A	uc004epr.2	-	8	2219	c.2219G>T	c.(2218-2220)CGT>CTT	p.R740L	AMOT_uc004eps.2_Missense_Mutation_p.R331L|AMOT_uc011mtc.1_5'Flank|hsa-mir-4329|MI0015901_5'Flank	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	740	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						GTCAAGGCAACGCTTATTGGC	0.453													A	112025789	A	A	112025789	3	1	164	1	0	0	0	0	1	0	0	0	582	536	19	5	1051	5	AMOT	23	112025789	Missense_Mutation	SNP	C	TCGA-19-5951-01A-11D-1696-08	40600132	112025789	43244771	89	11731											
FAM70A	55026	broad.mit.edu	37	chrX	119410875	119410875	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgctgacatcgatgtattcGtagtacccaccagtgatctc	8	12	1	2			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chrX:119410875G>T	uc004eso.3	-	8	839	c.612C>A	c.(610-612)TAC>TAA	p.Y204*	FAM70A_uc004esp.3_Nonsense_Mutation_p.Y180*|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	204						integral to membrane				lung(1)|breast(1)	2						CGATGTATTCGTAGTACCCAC	0.582													T	119410875	T	T	119410875	4	4	164	1	0	0	0	0	0	1	0	0	5605	1140	40	5	449	5	FAM70A	23	119410875	Nonsense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	7385086	119410875	35859685	90	11732											
GDI1	2664	broad.mit.edu	37	chrX	153666947	153666947	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggaacccctactacgggggcGagagctcctccatcacaccc	10	17	1	1			TCGA-19-5951-01A-11D-1696-08	TCGA-19-5951-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	57cf584c-8c95-42ec-9cb0-707228b70010	0de1bd85-87e3-4189-9c82-206b20e4428f	g.chrX:153666947G>A	uc004fli.3	+	2	466	c.124G>A	c.(124-126)GAG>AAG	p.E42K	GDI1_uc011mzo.1_Missense_Mutation_p.E42K	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	42					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTACGGGGGCGAGAGCTCCTC	0.617													A	153666947	A	A	153666947	3	1	164	1	0	0	0	0	1	0	0	0	6320	1059	37	2	130	2	GDI1	23	153666947	Missense_Mutation	SNP	G	TCGA-19-5951-01A-11D-1696-08	34256072	153666947	1603613	91	11733											
NBPF1	55672	broad.mit.edu	37	chr1	16893838	16893838	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttctcatccagcagctccCtgctgagcctggaacagtgg	10	14	1	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr1:16893838C>T	uc009vos.1	-	26	3788	c.2900G>A	c.(2899-2901)AGG>AAG	p.R967K	NBPF1_uc009vot.1_Missense_Mutation_p.R350K|NBPF1_uc001ayz.1_Missense_Mutation_p.R350K|NBPF1_uc010oce.1_Missense_Mutation_p.R621K	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	967	NBPF 6.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CAGCAGCTCCCTGCTGAGCCT	0.473													T	16893838	T	T	16893838	3	4	165	1	0	0	0	0	1	0	0	0	10192	681	24	3	769	3	NBPF1	1	16893838	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08		16893838	232356783	1	11734											
PLK3	1263	broad.mit.edu	37	chr1	45271002	45271002	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcccttgctgctgcagtgggTcaagacggatcaggctctcc	13	13	3	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr1:45271002T>C	uc001cmn.2	+	14	1800	c.1700T>C	c.(1699-1701)GTC>GCC	p.V567A	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	567	POLO box 2.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					CTGCAGTGGGTCAAGACGGAT	0.602													C	45271002	C	C	45271002	3	2	165	1	0	0	0	0	1	0	0	0	12097	1667	58	4	1754	4	PLK3	1	45271002	Missense_Mutation	SNP	T	TCGA-19-5952-01A-11D-1696-08	28377164	45271002	203979619	2	11735											
LGALS8	3964	broad.mit.edu	37	chr1	236700824	236700824	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cgtttgttggcaccattcctGatcagctggatcctggaact	10	11	1	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr1:236700824G>A	uc001hxz.1	+	4	454	c.73G>A	c.(73-75)GAT>AAT	p.D25N	LGALS8_uc001hxw.1_Missense_Mutation_p.D25N|LGALS8_uc001hxy.1_Missense_Mutation_p.D25N|LGALS8_uc009xgg.1_RNA|LGALS8_uc001hya.1_Missense_Mutation_p.D25N|LGALS8_uc001hyb.1_Missense_Mutation_p.D25N|LGALS8_uc001hyc.1_Missense_Mutation_p.D25N	NM_201543	NP_963837	O00214	LEG8_HUMAN	galectin-8 isoform b	25	Galectin 1.					cytoplasm|extracellular space	sugar binding			ovary(1)	1	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.0253)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CACCATTCCTGATCAGCTGGA	0.393													A	236700824	A	A	236700824	3	1	165	1	0	0	0	0	1	0	0	0	8747	1290	45	3	79	3	LGALS8	1	236700824	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	191429822	236700824	12549797	3	11736											
GPR17	2840	broad.mit.edu	37	chr2	128408657	128408657	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcttctacctcaacatgtaCgccagcatctacttcctcac	3	17	5	0	rs61749508		TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr2:128408657C>T	uc010yzn.1	+	4	1043	c.432C>T	c.(430-432)TAC>TAT	p.Y144Y	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.Y144Y|GPR17_uc010yzo.1_Silent_p.Y116Y|GPR17_uc002tpd.2_Silent_p.Y116Y	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	144	Helical; Name=3; (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		TCAACATGTACGCCAGCATCT	0.602													T	128408657	T	T	128408657	2	4	165	1	0	0	0	0	0	0	0	1	6667	547	19	1		1	GPR17	2	128408657	Silent	SNP	C	TCGA-19-5952-01A-11D-1696-08		128408657	114790716	4	11737											
TTN	7273	broad.mit.edu	37	chr2	179548796	179548796	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcttctgggacagctctcttCggttcctctggcactttaaa	8	12	4	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr2:179548796C>T	uc010zfg.1	-	130	29228	c.29004G>A	c.(29002-29004)CCG>CCA	p.P9668P	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.P6329P|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10595							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTCTCTTCGGTTCCTCTG	0.368													T	179548796	T	T	179548796	2	4	165	1	0	0	0	0	0	0	0	1	16732	871	31	2		2	TTN	2	179548796	Silent	SNP	C	TCGA-19-5952-01A-11D-1696-08	51140139	179548796	63650577	5	11738											
ACCN4	55515	broad.mit.edu	37	chr2	220379838	220379838	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcattcggcactcagcgatgCcgacatcttccacctggcca	9	16	2	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr2:220379838C>T	uc002vma.2	+	1	787	c.773C>T	c.(772-774)GCC>GTC	p.A258V	ACCN4_uc010fwi.1_Missense_Mutation_p.A258V|ACCN4_uc010fwj.1_Missense_Mutation_p.A258V|ACCN4_uc002vly.1_Missense_Mutation_p.A258V|ACCN4_uc002vlz.2_Missense_Mutation_p.A258V|ACCN4_uc002vmb.2_5'Flank	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	258	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		CTCAGCGATGCCGACATCTTC	0.657													T	220379838	T	T	220379838	3	4	165	1	0	0	0	0	1	0	0	0	131	739	26	3	775	3	ACCN4	2	220379838	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08	40831042	220379838	22819535	6	11739											
CX3CR1	1524	broad.mit.edu	37	chr3	39307959	39307959	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggcctcagccaaatcatcGtactcaaagttttctgtcac	6	13	5	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr3:39307959G>A	uc003cjl.2	-	2	134	c.42C>T	c.(40-42)TAC>TAT	p.Y14Y		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	14	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CCAAATCATCGTACTCAAAGT	0.443													A	39307959	A	A	39307959	2	1	165	1	0	0	0	0	0	0	0	1	4075	1140	40	1		1	CX3CR1	3	39307959	Silent	SNP	G	TCGA-19-5952-01A-11D-1696-08		39307959	158714471	7	11740											
WDR82	80335	broad.mit.edu	37	chr3	52292683	52292683	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attccagacatggatcttgcCatcctctgaacctaaagagg	8	11	2	3			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr3:52292683C>T	uc003ddl.2	-	8	1063	c.781G>A	c.(781-783)GGC>AGC	p.G261S	WDR82_uc003ddk.2_Missense_Mutation_p.G186S	NM_025222	NP_079498	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	261	WD 5.				histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding				0				BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		TGGATCTTGCCATCCTCTGAA	0.438													T	52292683	T	T	52292683	3	4	165	1	0	0	0	0	1	0	0	0	17328	594	21	3	168	3	WDR82	3	52292683	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08	12984724	52292683	145729747	8	11741											
TRH	7200	broad.mit.edu	37	chr3	129695840	129695840	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaggagctgggaagaagaGgaggaggaggaagagagaga	20	2	0	4			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr3:129695840G>A	uc003enc.2	+	3	1071	c.510G>A	c.(508-510)GAG>GAA	p.E170E		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	170					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						Gggaagaagaggaggaggagg	0.547													A	129695840	A	A	129695840	2	1	165	1	0	0	0	0	0	0	0	1	16475	991	35	3		3	TRH	3	129695840	Silent	SNP	G	TCGA-19-5952-01A-11D-1696-08	77403157	129695840	68326590	9	11742											
GFM1	85476	broad.mit.edu	37	chr3	158378683	158378683	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgttgaggaagtatatgcCggagacatctgtgcattgtt	13	5	1	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr3:158378683C>T	uc003fce.2	+	10	1349	c.1242C>T	c.(1240-1242)GCC>GCT	p.A414A	GFM1_uc003fcd.2_Silent_p.A414A|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Silent_p.A345A	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	414					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			AAGTATATGCCGGAGACATCT	0.353													T	158378683	T	T	158378683	2	4	165	1	0	0	0	0	0	0	0	1	6341	639	23	2		2	GFM1	3	158378683	Silent	SNP	C	TCGA-19-5952-01A-11D-1696-08	28682843	158378683	39643747	10	11743											
FGG	2266	broad.mit.edu	37	chr4	155528019	155528019	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaacttgtcactaggatcatCgccaaaatcaaagccatcaa	5	11	4	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr4:155528019C>T	uc003ioj.2	-	8	1108	c.967G>A	c.(967-969)GAT>AAT	p.D323N	FGG_uc003iog.2_Missense_Mutation_p.D323N|FGG_uc003ioh.2_Missense_Mutation_p.D331N|FGG_uc010ipx.2_Missense_Mutation_p.D151N|FGG_uc010ipy.2_Missense_Mutation_p.D34N|FGG_uc003ioi.2_Missense_Mutation_p.D34N|FGG_uc003iok.2_Missense_Mutation_p.D331N	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	323	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CTAGGATCATCGCCAAAATCA	0.468													T	155528019	T	T	155528019	3	4	165	1	0	0	0	0	1	0	0	0	5870	884	31	2	421	2	FGG	4	155528019	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08		155528019	35626257	11	11744											
IRX4	50805	broad.mit.edu	37	chr5	1880903	1880903	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcggcagcggctggtgccaGgcccccatgcgcagatcccg	16	16	0	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr5:1880903G>A	uc003jcz.2	-	3	462	c.343C>T	c.(343-345)CTG>TTG	p.L115L	IRX4_uc011cmf.1_5'UTR	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	115					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		GCTGGTGCCAGGCCCCCATGC	0.622													A	1880903	A	A	1880903	2	1	165	1	0	0	0	0	0	0	0	1	7846	991	35	3		3	IRX4	5	1880903	Silent	SNP	G	TCGA-19-5952-01A-11D-1696-08		1880903	179034357	12	11745											
TRPC7	57113	broad.mit.edu	37	chr5	135692954	135692954	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaagcgctcctcctcgggcGtcagactggtgcccttctcg	13	15	2	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr5:135692954G>A	uc003lbn.1	-	1	122	c.119C>T	c.(118-120)ACG>ATG	p.T40M	TRPC7_uc010jef.1_Missense_Mutation_p.T32M|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.T32M|TRPC7_uc010jei.1_Missense_Mutation_p.T32M|TRPC7_uc010jej.1_Translation_Start_Site	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	41	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTCCTCGGGCGTCAGACTGGT	0.602													A	135692954	A	A	135692954	3	1	165	1	0	0	0	0	1	0	0	0	16581	1145	40	1	2510	1	TRPC7	5	135692954	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	133812051	135692954	45222306	13	11746											
PCDHGA6	56109	broad.mit.edu	37	chr5	140754770	140754770	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccctttttcaagtgttcgatCgagactctggcctgaatggc	10	11	2	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr5:140754770C>T	uc003ljy.1	+	1	1120	c.1120C>T	c.(1120-1122)CGA>TGA	p.R374*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Nonsense_Mutation_p.R374*	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	374	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGTTCGATCGAGACTCTGG	0.428													T	140754770	T	T	140754770	4	4	165	1	0	0	0	0	0	1	0	0	11558	876	31	2	1122	2	PCDHGA6	5	140754770	Nonsense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08	5061816	140754770	40160490	14	11747											
FBXO38	81545	broad.mit.edu	37	chr5	147807296	147807296	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccggatggtacgagatcCgccttttcctttaggactct	11	12	1	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr5:147807296C>T	uc003lpf.1	+	15	2559	c.2439C>T	c.(2437-2439)TCC>TCT	p.S813S	FBXO38_uc003lpg.1_Intron|FBXO38_uc003lph.2_Intron	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	813						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTACGAGATCCGCCTTTTCCT	0.567													T	147807296	T	T	147807296	2	4	165	1	0	0	0	0	0	0	0	1	5746	639	23	2		2	FBXO38	5	147807296	Silent	SNP	C	TCGA-19-5952-01A-11D-1696-08	7052526	147807296	33107964	15	11748											
FAM54A	113115	broad.mit.edu	37	chr6	136554632	136554632	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgaatgggtctaccgccaGgtgacctattttttaaaaaa	8	7	1	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr6:136554632G>A	uc010kgp.1	-	7	1265	c.875C>T	c.(874-876)CCT>CTT	p.P292L	FAM54A_uc003qgt.1_Missense_Mutation_p.P292L|FAM54A_uc003qgu.1_Missense_Mutation_p.P249L	NM_001099286	NP_001092756	Q6P444	FA54A_HUMAN	DUF729 domain containing 1	292										skin(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00228)|OV - Ovarian serous cystadenocarcinoma(155;0.00504)		TCTACCGCCAGGTGACCtatt	0.313													A	136554632	A	A	136554632	3	1	165	1	0	0	0	0	1	0	0	0	5582	1000	35	3	290	3	FAM54A	6	136554632	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08		136554632	34560435	16	11749											
SDK1	221935	broad.mit.edu	37	chr7	3991529	3991529	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcttttgaaccggccagggCgacggcctttcttttcatca	10	13	3	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr7:3991529C>T	uc003smx.2	+	7	1266	c.1127C>T	c.(1126-1128)GCG>GTG	p.A376V		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	376	Ig-like C2-type 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCGGCCAGGGCGACGGCCTTT	0.577													T	3991529	T	T	3991529	3	4	165	1	0	0	0	0	1	0	0	0	13968	768	27	1	1153	1	SDK1	7	3991529	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08		3991529	155147134	17	11750											
CALCR	799	broad.mit.edu	37	chr7	93055883	93055883	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgaattgggcccattggcGcttcacggtggtttggacct	13	9	1	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr7:93055883G>A	uc003umv.1	-	15	1573	c.1312C>T	c.(1312-1314)CGC>TGC	p.R438C	CALCR_uc011kia.1_Missense_Mutation_p.R218C|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.R404C|CALCR_uc003umw.2_Missense_Mutation_p.R404C	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	420	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GCCCATTGGCGCTTCACGGTG	0.537													A	93055883	A	A	93055883	3	1	165	1	0	0	0	0	1	0	0	0	2579	1087	38	1	218	1	CALCR	7	93055883	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	89064354	93055883	66082780	18	11751											
KIAA1549	57670	broad.mit.edu	37	chr7	138593736	138593736	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgcattcagtgatattctcaCctgcaccgtgaggttatacg	9	10	2	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr7:138593736C>A	uc011kql.1	-	5	3325	c.3276_splice	c.e5+1	p.Q1092_splice	KIAA1549_uc003vuk.3_Splice_Site_p.Q1042_splice|KIAA1549_uc011kqj.1_Splice_Site_p.Q1092_splice	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1							integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GATATTCTCACCTGCACCGTG	0.468			O	BRAF	pilocytic astrocytoma								A	138593736	A	A	138593736	5	1	165	1	0	0	0	0	0	0	1	0	8244	521	18	5	2639	5	KIAA1549	7	138593736	Splice_Site	SNP	C	TCGA-19-5952-01A-11D-1696-08	45537853	138593736	20544927	19	11752											
PRKAG2	51422	broad.mit.edu	37	chr7	151261177	151261177	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtctcacctcagctcttactAttctgtccacgatggtctcc	6	15	5	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr7:151261177A>T	uc003wkk.2	-	14	2182	c.1571T>A	c.(1570-1572)ATA>AAA	p.I524K	PRKAG2_uc003wki.2_Missense_Mutation_p.I283K|PRKAG2_uc011kvl.1_Missense_Mutation_p.I399K|PRKAG2_uc003wkj.2_Missense_Mutation_p.I480K|PRKAG2_uc003wkl.2_Missense_Mutation_p.I72K	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	524	CBS 4.				ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		AGCTCTTACTATTCTGTCCAC	0.517													T	151261177	T	T	151261177	3	4	165	1	0	0	0	0	1	0	0	0	12501	449	16	5	150	5	PRKAG2	7	151261177	Missense_Mutation	SNP	A	TCGA-19-5952-01A-11D-1696-08	12667441	151261177	7877486	20	11753											
FRMD3	257019	broad.mit.edu	37	chr9	85913683	85913683	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgcacctcaggaggctcCctctggatcttggaactggc	12	13	3	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr9:85913683C>T	uc004ams.1	-	12	1252	c.1050G>A	c.(1048-1050)AGG>AGA	p.R350R	FRMD3_uc004amr.1_Silent_p.R336R	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	350						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						CAGGAGGCTCCCTCTGGATCT	0.493													T	85913683	T	T	85913683	2	4	165	1	0	0	0	0	0	0	0	1	6050	622	22	3		3	FRMD3	9	85913683	Silent	SNP	C	TCGA-19-5952-01A-11D-1696-08		85913683	55299748	21	11754											
LRRC8A	56262	broad.mit.edu	37	chr9	131669841	131669841	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacctggtgcttctgcacaCgctcatcttcctggcctgca	8	16	3	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr9:131669841C>T	uc004bwl.3	+	3	652	c.398C>T	c.(397-399)ACG>ATG	p.T133M	LRRC8A_uc010myp.2_Missense_Mutation_p.T133M|LRRC8A_uc010myq.2_Missense_Mutation_p.T133M	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	133	Helical; (Potential).				pre-B cell differentiation	integral to membrane					0						CTTCTGCACACGCTCATCTTC	0.557													T	131669841	T	T	131669841	3	4	165	1	0	0	0	0	1	0	0	0	9021	536	19	1	400	1	LRRC8A	9	131669841	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08	45756158	131669841	9543590	22	11755											
APBB1IP	54518	broad.mit.edu	37	chr10	26849669	26849672	+	Frame_Shift_Del	DEL	CTCT	-	-													ctctccccagtatgggaagaCtctctatgataactaccagc					rs145279460		TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr10:26849669_26849672delCTCT	uc001iss.2	+	13	1586_1589	c.1265_1268delCTCT	c.(1264-1269)ACTCTCfs	p.T422fs		NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	422_423				L -> F (in Ref. 1; BAC41256).	blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						TATGGGAAGACTCTCTATGATAAC	0.461													-	26849672	-	-	26849669	7	5	165	1	0	1	0	1	0	0	0	0	760	565	20	0	1307	0	APBB1IP	10	26849669	Frame_Shift_Del	DEL	CTCT	TCGA-19-5952-01A-11D-1696-08		26849669	108685078	23	11756											
SYT15	83849	broad.mit.edu	37	chr10	46965845	46965845	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gcctgtccacgtggtagacgGagaacttcagcaccctctgg	12	13	2	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr10:46965845G>T	uc001jea.2	-	5	845	c.692C>A	c.(691-693)TCC>TAC	p.S231Y	SYT15_uc001jdz.2_Missense_Mutation_p.S231Y|SYT15_uc001jeb.2_Missense_Mutation_p.S109Y|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	231	Cytoplasmic (Potential).|C2 1.					integral to membrane|plasma membrane					0						GTGGTAGACGGAGAACTTCAG	0.622													T	46965845	T	T	46965845	3	4	165	1	0	0	0	0	1	0	0	0	15468	1174	41	5	643	5	SYT15	10	46965845	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	20116176	46965845	88568902	24	11757											
PTEN	5728	broad.mit.edu	37	chr10	89692911	89692911	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctggaaagggacgaactgGtgtaatgatatgtgcatatt	13	4	0	1	rs121909241		TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr10:89692911G>A	uc001kfb.2	+	6	1426	c.395G>A	c.(394-396)GGT>GAT	p.G132D		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	132	Phosphatase tensin-type.		G -> V (in one patient with clinical findings suggesting hamartoma tumor syndrome).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.G132D(5)|p.R55fs*1(4)|p.?(2)|p.G132S(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G132V(1)|p.K128fs*47(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.G132fs*2(1)|p.G132R(1)|p.T131fs*42(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGACGAACTGGTGTAATGATA	0.398		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89692911	A	A	89692911	3	1	165	1	0	0	0	0	1	0	0	0	12738	1261	44	3	413	3	PTEN	10	89692911	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	42727066	89692911	45841836	25	11758											
PSD	5662	broad.mit.edu	37	chr10	104171572	104171572	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaggccagctccttcagaaAcaccctggagaaggggcaag	12	11	1	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr10:104171572A>G	uc001kvg.1	-	8	2361	c.1834T>C	c.(1834-1836)TTT>CTT	p.F612L	PSD_uc001kvf.1_5'Flank|PSD_uc001kvh.1_Missense_Mutation_p.F233L|PSD_uc009xxd.1_Missense_Mutation_p.F612L	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	612	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TCCTTCAGAAACACCCTGGAG	0.582													G	104171572	G	G	104171572	3	3	165	1	0	0	0	0	1	0	0	0	12646	43	2	4	1280	4	PSD	10	104171572	Missense_Mutation	SNP	A	TCGA-19-5952-01A-11D-1696-08	14478661	104171572	31363175	26	11759											
OR8K3	219473	broad.mit.edu	37	chr11	56086192	56086192	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gctatacacagtaatcatgtCacgaagggtatgtcaggtgc	11	8	3	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr11:56086192C>T	uc010rjf.1	+	1	410	c.410C>T	c.(409-411)TCA>TTA	p.S137L		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					GTAATCATGTCACGAAGGGTA	0.413													T	56086192	T	T	56086192	3	4	165	1	0	0	0	0	1	0	0	0	11244	838	29	3	412	3	OR8K3	11	56086192	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08		56086192	78920324	27	11760											
OR5B3	441608	broad.mit.edu	37	chr11	58170525	58170525	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgcacactgctgcatagcGgtcataggccattgaggcca	11	11	1	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr11:58170525G>A	uc010rkf.1	-	1	358	c.358C>T	c.(358-360)CGC>TGC	p.R120C		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GCTGCATAGCGGTCATAGGCC	0.468													A	58170525	A	A	58170525	3	1	165	1	0	0	0	0	1	0	0	0	11152	1116	39	2	588	2	OR5B3	11	58170525	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	2084333	58170525	76835991	28	11761											
CLPB	81570	broad.mit.edu	37	chr11	72114088	72114088	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cattgacatctgcaccttctGacaacagcctaaaacaagac	5	13	2	3			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr11:72114088G>C	uc001osj.2	-	3	514	c.464C>G	c.(463-465)TCA>TGA	p.S155*	CLPB_uc010rqx.1_Nonsense_Mutation_p.S110*|CLPB_uc010rqy.1_Intron|CLPB_uc001osk.2_Nonsense_Mutation_p.S155*|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Intron	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	155	ANK 1.				cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						TGCACCTTCTGACAACAGCCT	0.458													C	72114088	C	C	72114088	4	2	165	1	0	0	0	0	0	1	0	0	3551	1294	45	5	1719	5	CLPB	11	72114088	Nonsense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	13943563	72114088	62892428	29	11762											
MMP1	4312	broad.mit.edu	37	chr11	102665949	102665949	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccccgaatcgtagttatagcAtcaaaggttagcttactgtc	8	10	1	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr11:102665949A>T	uc001phi.2	-	6	998	c.855T>A	c.(853-855)GAT>GAA	p.D285E	uc001phh.1_RNA|MMP1_uc010ruv.1_Missense_Mutation_p.D219E	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	285	Hemopexin-like 1.	Calcium 4; via carbonyl oxygen (By similarity).			blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		TAGTTATAGCATCAAAGGTTA	0.403													T	102665949	T	T	102665949	3	4	165	1	0	0	0	0	1	0	0	0	9648	214	8	5	574	5	MMP1	11	102665949	Missense_Mutation	SNP	A	TCGA-19-5952-01A-11D-1696-08	30551861	102665949	32340567	30	11763											
DSCAML1	57453	broad.mit.edu	37	chr11	117329509	117329509	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagagcacactgctgcgtaCgccgtccccagcctgggtgt	13	14	0	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr11:117329509C>T	uc001prh.1	-	19	3711	c.3709G>A	c.(3709-3711)GTA>ATA	p.V1237I		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1177	Fibronectin type-III 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CTGCTGCGTACGCCGTCCCCA	0.652													T	117329509	T	T	117329509	3	4	165	1	0	0	0	0	1	0	0	0	4769	536	19	1	2692	1	DSCAML1	11	117329509	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08	14663560	117329509	17677007	31	11764											
KIAA1467	57613	broad.mit.edu	37	chr12	13215874	13215874	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	acttggatgaagacggtgttCgagaccttgtggttctggcc	14	8	1	3			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr12:13215874C>G	uc001rbi.2	+	5	840	c.817C>G	c.(817-819)CGA>GGA	p.R273G	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	273						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		AGACGGTGTTCGAGACCTTGT	0.448													G	13215874	G	G	13215874	3	3	165	1	0	0	0	0	1	0	0	0	8235	876	31	5	835	5	KIAA1467	12	13215874	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08		13215874	120636021	32	11765											
PIK3C2G	5288	broad.mit.edu	37	chr12	18435551	18435551	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagtagcattcctccaacaaAttcatccttctcaagtgact	4	12	2	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr12:18435551A>G	uc001rdt.2	+	2	652	c.536A>G	c.(535-537)AAT>AGT	p.N179S	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.N179S|PIK3C2G_uc010sic.1_5'UTR	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	179					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CCTCCAACAAATTCATCCTTC	0.343													G	18435551	G	G	18435551	3	3	165	1	0	0	0	0	1	0	0	0	11911	101	4	4	538	4	PIK3C2G	12	18435551	Missense_Mutation	SNP	A	TCGA-19-5952-01A-11D-1696-08	5219677	18435551	115416344	33	11766											
TMEM132D	121256	broad.mit.edu	37	chr12	129559351	129559351	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttaactttgatgtttgccGttccaacagctaacacactc	5	11	0	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr12:129559351G>A	uc009zyl.1	-	9	2697	c.2369C>T	c.(2368-2370)ACG>ATG	p.T790M	TMEM132D_uc001uia.2_Missense_Mutation_p.T328M	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	790	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GATGTTTGCCGTTCCAACAGC	0.483													A	129559351	A	A	129559351	3	1	165	1	0	0	0	0	1	0	0	0	16044	1145	40	1	934	1	TMEM132D	12	129559351	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	111123800	129559351	4292544	34	11767											
ADCY4	196883	broad.mit.edu	37	chr14	24787905	24787905	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctccatgcggctggccacGttcactgtgttgccccaaat	9	15	2	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr14:24787905G>A	uc001wov.2	-	24	3042	c.3036C>T	c.(3034-3036)AAC>AAT	p.N1012N	ADCY4_uc001wow.2_Silent_p.N1012N|ADCY4_uc010toh.1_Silent_p.N698N|ADCY4_uc001wox.2_Silent_p.N1012N|ADCY4_uc001woy.2_Silent_p.N1012N	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	1012	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GGCTGGCCACGTTCACTGTGT	0.537													A	24787905	A	A	24787905	2	1	165	1	0	0	0	0	0	0	0	1	296	1136	40	1		1	ADCY4	14	24787905	Silent	SNP	G	TCGA-19-5952-01A-11D-1696-08		24787905	82561635	35	11768											
SERPINA1	5265	broad.mit.edu	37	chr14	94849557	94849557	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagcaggaggatgccccaCgagacagaagacggcattgt	14	11	0	3			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr14:94849557C>T	uc001ycx.3	-	2	279	c.18G>A	c.(16-18)TCG>TCA	p.S6S	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Silent_p.S6S|SERPINA1_uc010aux.2_Silent_p.S6S|SERPINA1_uc001ycy.3_Silent_p.S6S|SERPINA1_uc010auy.2_Silent_p.S6S|SERPINA1_uc001ycz.3_Silent_p.S6S|SERPINA1_uc010auz.2_Silent_p.S6S|SERPINA1_uc010ava.2_Silent_p.S6S|SERPINA1_uc001ydb.3_Silent_p.S6S|SERPINA1_uc010avb.2_Silent_p.S6S|SERPINA1_uc001ydc.3_Silent_p.S6S|SERPINA1_uc001yda.1_Silent_p.S6S	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	6					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	GGATGCCCCACGAGACAGAAG	0.612									Alpha-1-Antitrypsin_Deficiency				T	94849557	T	T	94849557	2	4	165	1	0	0	0	0	0	0	0	1	14086	523	19	1		1	SERPINA1	14	94849557	Silent	SNP	C	TCGA-19-5952-01A-11D-1696-08	70061652	94849557	12499983	36	11769											
RYR3	6263	broad.mit.edu	37	chr15	34064164	34064164	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctggtgaaggctgggttaCgagcattctttgaaaatgct	13	6	1	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr15:34064164C>T	uc001zhi.2	+	63	8930	c.8860C>T	c.(8860-8862)CGA>TGA	p.R2954*	RYR3_uc010bar.2_Nonsense_Mutation_p.R2954*	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2954	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGCTGGGTTACGAGCATTCTT	0.448													T	34064164	T	T	34064164	4	4	165	1	0	0	0	0	0	1	0	0	13770	528	19	1	9110	1	RYR3	15	34064164	Nonsense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08		34064164	68467228	37	11770											
ODF4	146852	broad.mit.edu	37	chr17	8243551	8243551	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taacaggtccttgggccagcGccagaactctccgctgccct	10	16	1	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr17:8243551G>A	uc002gle.1	+	1	364	c.182G>A	c.(181-183)CGC>CAC	p.R61H		NM_153007	NP_694552	Q2M2E3	ODFP4_HUMAN	outer dense fiber of sperm tails 4	61					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)	1						TTGGGCCAGCGCCAGAACTCT	0.587													A	8243551	A	A	8243551	3	1	165	1	0	0	0	0	1	0	0	0	10833	1087	38	1	184	1	ODF4	17	8243551	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08		8243551	72951659	38	11771											
PPP1R1B	84152	broad.mit.edu	37	chr17	37791907	37791907	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctggaagggccctgggagCgcccaccccctctggatgag	15	14	2	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr17:37791907C>T	uc002hrz.2	+	6	960	c.493C>T	c.(493-495)CGC>TGC	p.R165C	PPP1R1B_uc002hsa.2_Missense_Mutation_p.R176C|PPP1R1B_uc010cvx.2_Missense_Mutation_p.R132C|PPP1R1B_uc002hsb.2_Missense_Mutation_p.R129C|PPP1R1B_uc002hsc.2_Missense_Mutation_p.R129C|STARD3_uc010weg.1_5'Flank|STARD3_uc002hsd.2_5'Flank|STARD3_uc010weh.1_5'Flank|STARD3_uc002hse.2_5'Flank|STARD3_uc010wei.1_5'Flank	NM_032192	NP_115568	Q9UD71	PPR1B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	165					signal transduction	cytosol	protein kinase inhibitor activity|protein phosphatase inhibitor activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCCCTGGGAGCGCCCACCCCC	0.582													T	37791907	T	T	37791907	3	4	165	1	0	0	0	0	1	0	0	0	12368	768	27	1	515	1	PPP1R1B	17	37791907	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08	29548356	37791907	43403303	39	11772											
INTS2	57508	broad.mit.edu	37	chr17	59952385	59952385	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggctgaagtgcattaaccGtcattacccatagcctgata	8	10	1	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr17:59952385G>A	uc002izn.2	-	19	2571	c.2495C>T	c.(2494-2496)ACG>ATG	p.T832M	INTS2_uc002izm.2_Missense_Mutation_p.T824M	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	832					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						TGCATTAACCGTCATTACCCA	0.343													A	59952385	A	A	59952385	3	1	165	1	0	0	0	0	1	0	0	0	7778	1145	40	1	1147	1	INTS2	17	59952385	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	22160478	59952385	21242825	40	11773											
TANC2	26115	broad.mit.edu	37	chr17	61271350	61271350	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttcaatgccttcttgttacAggtgatgctgaacaggagct	10	9	2	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr17:61271350A>G	uc002jal.3	+	4	235	c.212_splice	c.e4-2	p.G71_splice	TANC2_uc010wpe.1_5'Flank	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and								binding			ovary(2)	2						TTCTTGTTACAGGTGATGCTG	0.423													G	61271350	G	G	61271350	5	3	165	1	0	0	0	0	0	0	1	0	15542	202	7	4	224	4	TANC2	17	61271350	Splice_Site	SNP	A	TCGA-19-5952-01A-11D-1696-08	1318965	61271350	19923860	41	11774											
PCYT2	5833	broad.mit.edu	37	chr17	79864762	79864762	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccccggtccaggggttccGcccaccagggcactgcaagc	12	17	0	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr17:79864762G>A	uc002kcf.1	-	7	613	c.550C>T	c.(550-552)CGG>TGG	p.R184W	PCYT2_uc010wva.1_Missense_Mutation_p.R152W|PCYT2_uc010wvb.1_Missense_Mutation_p.R152W|PCYT2_uc002kce.1_Missense_Mutation_p.R106W|PCYT2_uc002kcg.1_Missense_Mutation_p.R213W|PCYT2_uc002kch.1_Missense_Mutation_p.R202W|PCYT2_uc002kci.1_Missense_Mutation_p.R143W|PCYT2_uc010dii.1_Missense_Mutation_p.R184W|PCYT2_uc010wvc.1_Missense_Mutation_p.R106W	NM_002861	NP_002852	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	184	Catalytic 1 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CAGGGGTTCCGCCCACCAGGG	0.622													A	79864762	A	A	79864762	3	1	165	1	0	0	0	0	1	0	0	0	11612	1086	38	1	647	1	PCYT2	17	79864762	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	18593412	79864762	1330448	42	11775											
DSC3	1825	broad.mit.edu	37	chr18	28605880	28605880	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctgtgctgcatcagattcaAcctaaaagtagaaaaaaaat	6	7	3	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr18:28605880A>G	uc002kwj.3	-	5	631	c.476T>C	c.(475-477)GTT>GCT	p.V159A	DSC3_uc002kwi.3_Missense_Mutation_p.V159A	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	159	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			ATCAGATTCAACCTAAAAGTA	0.264													G	28605880	G	G	28605880	3	3	165	1	0	0	0	0	1	0	0	0	4767	57	2	4	2293	4	DSC3	18	28605880	Missense_Mutation	SNP	A	TCGA-19-5952-01A-11D-1696-08		28605880	49471368	43	11776											
DSG4	147409	broad.mit.edu	37	chr18	28991295	28991295	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccgttggcctcatggccGcaggggccgcaggagcctca	15	15	2	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr18:28991295G>A	uc002kwq.2	+	15	2374	c.2239G>A	c.(2239-2241)GCA>ACA	p.A747T	DSG4_uc002kwr.2_Missense_Mutation_p.A766T	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	747	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCTCATggccgcaggggccgc	0.473													A	28991295	A	A	28991295	3	1	165	1	0	0	0	0	1	0	0	0	4779	1087	38	1	2418	1	DSG4	18	28991295	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08	385415	28991295	49085953	44	11777											
POLRMT	5442	broad.mit.edu	37	chr19	618520	618522	+	In_Frame_Del	DEL	GGA	-	-													agggcggtgagcatcatgtgGgaggagtccagcgagtggat							TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr19:618520_618522delGGA	uc002lpf.1	-	17	3444_3446	c.3388_3390delTCC	c.(3388-3390)TCCdel	p.S1130del		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	1130	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCATCATGTGGGAGGAGTCCAGC	0.66													-	618522	-	-	618520	7	5	165	1	0	1	0	1	0	0	0	0	12238	1219	43	0	322	0	POLRMT	19	618520	In_Frame_Del	DEL	GGA	TCGA-19-5952-01A-11D-1696-08		618520	58510463	45	11778											
ZNF681	148213	broad.mit.edu	37	chr19	23927954	23927954	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctctgggtagttggcaaaCattggttaagtccattataa	10	6	1	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr19:23927954C>T	uc002nrk.3	-	4	540	c.398G>A	c.(397-399)TGT>TAT	p.C133Y	ZNF681_uc002nrl.3_Missense_Mutation_p.C64Y|ZNF681_uc002nrj.3_Missense_Mutation_p.C64Y	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				AGTTGGCAAACATTGGTTAAG	0.313													T	23927954	T	T	23927954	3	4	165	1	0	0	0	0	1	0	0	0	18085	478	17	3	1543	3	ZNF681	19	23927954	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08	23309434	23927954	35201029	46	11779											
PRODH2	58510	broad.mit.edu	37	chr19	36293096	36293096	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggagccattcacatacccaGtgctagagagacgtggtcac	12	11	2	2			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr19:36293096G>A	uc002obx.1	-	10	1441	c.1423C>T	c.(1423-1425)CTG>TTG	p.L475L		NM_021232	NP_067055	Q9UF12	PROD2_HUMAN	kidney and liver proline oxidase 1	475					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			ovary(2)	2	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CACATACCCAGTGCTAGAGAG	0.577													A	36293096	A	A	36293096	2	1	165	1	0	0	0	0	0	0	0	1	12549	1020	36	3		3	PRODH2	19	36293096	Silent	SNP	G	TCGA-19-5952-01A-11D-1696-08	12365142	36293096	22835887	47	11780											
PSG7	5676	broad.mit.edu	37	chr19	43439731	43439731	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatatttaattatttgaccGtctactatatatgatgtaac	4	7	1	2	rs140238439	by1000genomes	TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr19:43439731G>A	uc002ovl.3	-	2	357	c.255C>T	c.(253-255)GAC>GAT	p.D85D	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	85	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTATTTGACCGTCTACTATAT	0.418													A	43439731	A	A	43439731	2	1	165	1	0	0	0	0	0	0	0	1	12660	1136	40	1		1	PSG7	19	43439731	Silent	SNP	G	TCGA-19-5952-01A-11D-1696-08	7146635	43439731	15689252	48	11781											
PVR	5817	broad.mit.edu	37	chr19	45153193	45153193	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcccaaatcacctggcaCtcagacctgggcgggatgcc	11	16	2	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr19:45153193C>T	uc002ozm.2	+	3	839	c.540C>T	c.(538-540)CAC>CAT	p.H180H	PVR_uc010ejs.2_Silent_p.H180H|PVR_uc010xxb.1_Silent_p.H180H|PVR_uc010xxc.1_Silent_p.H180H|PVR_uc002ozn.2_Silent_p.H125H	NM_006505	NP_006496	P15151	PVR_HUMAN	poliovirus receptor isoform alpha	180	Extracellular (Potential).|Ig-like C2-type 1.				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		TCACCTGGCACTCAGACCTGG	0.632													T	45153193	T	T	45153193	2	4	165	1	0	0	0	0	0	0	0	1	12837	564	20	3		3	PVR	19	45153193	Silent	SNP	C	TCGA-19-5952-01A-11D-1696-08	1713462	45153193	13975790	49	11782											
VSTM1	284415	broad.mit.edu	37	chr19	54567025	54567025	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagcagggagaggaattctgCggtcatagcgtcccttctgc	13	10	3	1			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr19:54567025C>T	uc002qcw.3	-	1	183	c.7G>A	c.(7-9)GCA>ACA	p.A3T	VSTM1_uc010erb.2_RNA|VSTM1_uc002qcx.3_Missense_Mutation_p.A3T	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	3						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		AGGAATTCTGCGGTCATAGCG	0.627													T	54567025	T	T	54567025	3	4	165	1	0	0	0	0	1	0	0	0	17225	768	27	1	739	1	VSTM1	19	54567025	Missense_Mutation	SNP	C	TCGA-19-5952-01A-11D-1696-08	9413832	54567025	4561958	50	11783											
SLCO4A1	28231	broad.mit.edu	37	chr20	61297841	61297841	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagttctgcctgttctgcacCgttgtcagcctgctgggcat	11	12	3	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr20:61297841C>T	uc002ydb.1	+	7	1591	c.1386C>T	c.(1384-1386)ACC>ACT	p.T462T	SLCO4A1_uc002ydc.1_RNA|LOC100127888_uc002ydd.2_RNA|SLCO4A1_uc002yde.1_5'Flank	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	462	Helical; Name=9; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			TGTTCTGCACCGTTGTCAGCC	0.652													T	61297841	T	T	61297841	2	4	165	1	0	0	0	0	0	0	0	1	14729	639	23	2		2	SLCO4A1	20	61297841	Silent	SNP	C	TCGA-19-5952-01A-11D-1696-08		61297841	1727679	51	11784											
OSM	5008	broad.mit.edu	37	chr22	30660354	30660354	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagggtctgcaggaagccccGcctgcccagccccctcaggg	14	17	2	0			TCGA-19-5952-01A-11D-1696-08	TCGA-19-5952-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	483cad63-ca73-4b31-b4c7-9d73f2cb4186	1ed4b4f1-5d98-4490-87ee-303f7699f8f6	g.chr22:30660354G>A	uc003ahb.2	-	3	329	c.277C>T	c.(277-279)CGG>TGG	p.R93W		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	93					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			AGGAAGCCCCGCCTGCCCAGC	0.642													A	30660354	A	A	30660354	3	1	165	1	0	0	0	0	1	0	0	0	11291	1086	38	1	485	1	OSM	22	30660354	Missense_Mutation	SNP	G	TCGA-19-5952-01A-11D-1696-08		30660354	20644212	52	11785											
PADI6	353238	broad.mit.edu	37	chr1	17708559	17708559	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	catacctccaaggaagagtcGaagaaggcgagagtctactg	12	9	1	3			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:17708559G>A	uc001bak.1	+	6	651	c.651G>A	c.(649-651)TCG>TCA	p.S217S		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	209					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AGGAAGAGTCGAAGAAGGCGA	0.522													A	17708559	A	A	17708559	2	1	166	1	0	0	0	0	0	0	0	1	11381	1045	37	2		2	PADI6	1	17708559	Silent	SNP	G	TCGA-19-5953-01B-12D-1845-08		17708559	231542062	1	11786											
HP1BP3	50809	broad.mit.edu	37	chr1	21071371	21071371	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcctttcttgcactggttgcAggcttctttgaggagccacc	10	12	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:21071371A>G	uc001bdw.1	-	13	1721	c.1581T>C	c.(1579-1581)CCT>CCC	p.P527P	HP1BP3_uc001bdv.1_Silent_p.P489P|HP1BP3_uc010odh.1_Silent_p.P489P|HP1BP3_uc001bdy.1_Silent_p.P527P|HP1BP3_uc010odf.1_Silent_p.P186P|HP1BP3_uc010odg.1_Silent_p.P375P	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	527	Lys-rich.				nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		CACTGGTTGCAGGCTTCTTTG	0.458													G	21071371	G	G	21071371	2	3	166	1	0	0	0	0	0	0	0	1	7328	175	7	4		4	HP1BP3	1	21071371	Silent	SNP	A	TCGA-19-5953-01B-12D-1845-08	3362812	21071371	228179250	2	11787											
TINAGL1	64129	broad.mit.edu	37	chr1	32050587	32050587	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacacccaccagcagcagggCtgccgcggtgggcgtctcga	15	15	1	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:32050587C>T	uc001bta.2	+	7	933	c.807C>T	c.(805-807)GGC>GGT	p.G269G	TINAGL1_uc001bsz.2_Silent_p.G124G|TINAGL1_uc010ogj.1_Silent_p.G238G|TINAGL1_uc010ogk.1_Silent_p.G269G	NM_022164	NP_071447	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	269					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		AGCAGCAGGGCTGCCGCGGTG	0.627													T	32050587	T	T	32050587	2	4	166	1	0	0	0	0	0	0	0	1	15919	784	28	3		3	TINAGL1	1	32050587	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	10979216	32050587	217200034	3	11788											
WDR78	79819	broad.mit.edu	37	chr1	67301382	67301382	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgccattgtgatagccaaCggctaaaaggttaggtgctc	12	8	0	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:67301382C>T	uc001dcx.2	-	11	1716	c.1660G>A	c.(1660-1662)GTT>ATT	p.V554I	WDR78_uc009waw.2_Missense_Mutation_p.V300I|WDR78_uc009wax.2_Intron	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	554	WD 1.									ovary(2)	2						TGATAGCCAACGGCTAAAAGG	0.363													T	67301382	T	T	67301382	3	4	166	1	0	0	0	0	1	0	0	0	17325	536	19	1	914	1	WDR78	1	67301382	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	35250795	67301382	181949239	4	11789											
BARHL2	343472	broad.mit.edu	37	chr1	91182597	91182597	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctacggtatcaatctccgaAcagggagatggggtggcctg	14	10	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:91182597A>G	uc001dns.2	-	1	198	c.156T>C	c.(154-156)TGT>TGC	p.C52C		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	52						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		CAATCTCCGAACAGGGAGATG	0.607													G	91182597	G	G	91182597	2	3	166	1	0	0	0	0	0	0	0	1	1314	41	2	4		4	BARHL2	1	91182597	Silent	SNP	A	TCGA-19-5953-01B-12D-1845-08	23881215	91182597	158068024	5	11790											
HSD3B1	3283	broad.mit.edu	37	chr1	120056674	120056674	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgggtggaatctgaaaaaCggcggcaccctgtacacttg	12	10	1	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:120056674C>T	uc001ehv.1	+	4	673	c.528C>T	c.(526-528)AAC>AAT	p.N176N	HSD3B1_uc001ehw.2_Silent_p.N178N	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	176					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	ATCTGAAAAACGGCGGCACCC	0.507													T	120056674	T	T	120056674	2	4	166	1	0	0	0	0	0	0	0	1	7390	535	19	1		1	HSD3B1	1	120056674	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	28874077	120056674	129193947	6	11791											
PDE4DIP	9659	broad.mit.edu	37	chr1	144859794	144859794	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcttgtttccagggtcagtgCtggctgggaagttctggtta	15	7	2	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:144859794C>G	uc001elw.3	-	38	6581	c.6290G>C	c.(6289-6291)AGC>ACC	p.S2097T	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.S1991T|PDE4DIP_uc001elv.3_Missense_Mutation_p.S1104T	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2097					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGGGTCAGTGCTGGCTGGGAA	0.577			T	PDGFRB	MPD								G	144859794	G	G	144859794	3	3	166	1	0	0	0	0	1	0	0	0	11643	797	28	5	778	5	PDE4DIP	1	144859794	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	24803120	144859794	104390827	7	11792											
PDE4DIP	9659	broad.mit.edu	37	chr1	144859988	144859988	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggatttggtgacaggcatcCaggctgtaagctgagagaga	16	6	0	3			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:144859988C>G	uc001elw.3	-	38	6387	c.6096G>C	c.(6094-6096)CTG>CTC	p.L2032L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L1926L|PDE4DIP_uc001elv.3_Silent_p.L1039L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2032	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GACAGGCATCCAGGCTGTAAG	0.527			T	PDGFRB	MPD								G	144859988	G	G	144859988	2	3	166	1	0	0	0	0	0	0	0	1	11643	581	21	5		5	PDE4DIP	1	144859988	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	194	144859988	104390633	8	11793											
ADAMTSL4	54507	broad.mit.edu	37	chr1	150530495	150530495	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaccgccagctgcagtgccGgcaggaatttggggggggtg	19	10	0	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:150530495G>A	uc001eux.2	+	14	2488	c.2252G>A	c.(2251-2253)CGG>CAG	p.R751Q	ADAMTSL4_uc001euw.2_Missense_Mutation_p.R751Q|ADAMTSL4_uc009wlw.2_Missense_Mutation_p.R774Q|ADAMTSL4_uc010pcg.1_Missense_Mutation_p.R712Q|ADAMTSL4_uc009wlx.2_5'UTR	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	751	TSP type-1 2.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTGCAGTGCCGGCAGGAATTT	0.706													A	150530495	A	A	150530495	3	1	166	1	0	0	0	0	1	0	0	0	277	1116	39	2	2298	2	ADAMTSL4	1	150530495	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	5670507	150530495	98720126	9	11794											
FCGR3A	2214	broad.mit.edu	37	chr1	161518335	161518335	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggcctggcttgagatgagGctctcattgtgaaaccactg	13	9	1	3	rs145248243		TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:161518335G>A	uc001gat.3	-	4	332	c.195C>T	c.(193-195)AGC>AGT	p.S65S	FCGR3A_uc001gar.2_Silent_p.S101S|FCGR3A_uc001gas.2_Silent_p.S100S|FCGR3A_uc009wuh.2_Silent_p.S64S|FCGR3A_uc009wui.2_Silent_p.S65S	NM_001127595	NP_001121067	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor	65	Ig-like C2-type 1.|Extracellular (Potential).				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TTGAGATGAGGCTCTCATTGT	0.552													A	161518335	A	A	161518335	2	1	166	1	0	0	0	0	0	0	0	1	5784	1194	42	3		3	FCGR3A	1	161518335	Silent	SNP	G	TCGA-19-5953-01B-12D-1845-08	10987840	161518335	87732286	10	11795											
GORAB	92344	broad.mit.edu	37	chr1	170521169	170521169	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttacaggaagcggtttgacAgggctgaagcagagtacatt	13	7	0	3			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:170521169A>G	uc001gha.2	+	5	778	c.751A>G	c.(751-753)AGG>GGG	p.R251G	GORAB_uc009wvx.2_Missense_Mutation_p.R71G|GORAB_uc001ghb.2_Missense_Mutation_p.R71G|GORAB_uc001ghc.2_Missense_Mutation_p.R71G|GORAB_uc001ghd.2_Missense_Mutation_p.R44G	NM_152281	NP_689494	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting isoform a	251	Necessary for interaction with RCHY1.|Potential.					Golgi apparatus|nucleus					0						GCGGTTTGACAGGGCTGAAGC	0.398													G	170521169	G	G	170521169	3	3	166	1	0	0	0	0	1	0	0	0	6574	179	7	4	773	4	GORAB	1	170521169	Missense_Mutation	SNP	A	TCGA-19-5953-01B-12D-1845-08	9002834	170521169	78729452	11	11796											
PAPPA2	60676	broad.mit.edu	37	chr1	176563936	176563936	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggtcccctgaacagcccctTcatggcatcttgccgctctt	8	16	3	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:176563936T>C	uc001gkz.2	+	3	2360	c.1196T>C	c.(1195-1197)TTC>TCC	p.F399S	PAPPA2_uc001gky.1_Missense_Mutation_p.F399S|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	399					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AACAGCCCCTTCATGGCATCT	0.592													C	176563936	C	C	176563936	3	2	166	1	0	0	0	0	1	0	0	0	11433	1783	62	4	1202	4	PAPPA2	1	176563936	Missense_Mutation	SNP	T	TCGA-19-5953-01B-12D-1845-08	6042767	176563936	72686685	12	11797											
ANGPTL1	9068	broad.mit.edu	37	chr1	178822880	178822880	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcatataaatcccactgaccGaatgcccagcttcttttgct	5	13	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:178822880G>A	uc001gma.2	-	4	1342	c.866C>T	c.(865-867)TCG>TTG	p.S289L	RALGPS2_uc001gly.1_Intron|RALGPS2_uc001glz.2_Intron|RALGPS2_uc010pnb.1_Intron|ANGPTL1_uc001gmb.2_Missense_Mutation_p.S289L|ANGPTL1_uc010pnc.1_Missense_Mutation_p.S211L	NM_004673	NP_004664	O95841	ANGL1_HUMAN	angiopoietin-like 1 precursor	289	Fibrinogen C-terminal.					extracellular space	receptor binding				0						CCCACTGACCGAATGCCCAGC	0.373													A	178822880	A	A	178822880	3	1	166	1	0	0	0	0	1	0	0	0	613	1059	37	2	621	2	ANGPTL1	1	178822880	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	2258944	178822880	70427741	13	11798											
KIAA1614	57710	broad.mit.edu	37	chr1	180914469	180914469	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	acttcaccacggcgtgccctCagtgtggaggacgtgggtgc	15	12	2	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:180914469C>T	uc001gok.2	+	9	3385	c.3318C>T	c.(3316-3318)CTC>CTT	p.L1106L	KIAA1614_uc001gol.1_Silent_p.L727L|KIAA1614_uc001gom.1_Silent_p.L197L|STX6_uc009wxo.1_RNA	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	1106										ovary(3)|skin(1)	4						GGCGTGCCCTCAGTGTGGAGG	0.662													T	180914469	T	T	180914469	2	4	166	1	0	0	0	0	0	0	0	1	8248	813	29	3		3	KIAA1614	1	180914469	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	2091589	180914469	68336152	14	11799											
LAMB3	3914	broad.mit.edu	37	chr1	209796522	209796522	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atctgcctggagttgccacaGagctgtggacagatggcggt	15	9	1	2			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:209796522G>T	uc001hhg.2	-	16	2751	c.2361C>A	c.(2359-2361)CTC>CTA	p.L787L	LAMB3_uc009xco.2_Silent_p.L787L|LAMB3_uc001hhh.2_Silent_p.L787L|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	787	Domain alpha.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AGTTGCCACAGAGCTGTGGAC	0.572													T	209796522	T	T	209796522	2	4	166	1	0	0	0	0	0	0	0	1	8612	929	33	5		5	LAMB3	1	209796522	Silent	SNP	G	TCGA-19-5953-01B-12D-1845-08	28882053	209796522	39454099	15	11800											
TRIM58	25893	broad.mit.edu	37	chr1	248039229	248039229	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagctggatcccgccacggCgcacccgagtctgctcttga	11	15	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr1:248039229C>T	uc001ido.2	+	6	947	c.899C>T	c.(898-900)GCG>GTG	p.A300V	OR2W3_uc001idp.1_5'UTR	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	300	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCCGCCACGGCGCACCCGAGT	0.552													T	248039229	T	T	248039229	3	4	166	1	0	0	0	0	1	0	0	0	16528	768	27	1	921	1	TRIM58	1	248039229	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	38242707	248039229	1211392	16	11801											
APOB	338	broad.mit.edu	37	chr2	21232448	21232448	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catctacaaactggtggtaaTcaaatgactttaatttcttt	5	7	3	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr2:21232448T>C	uc002red.2	-	26	7420	c.7292A>G	c.(7291-7293)GAT>GGT	p.D2431G		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2431					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGGTGGTAATCAAATGACTT	0.343													C	21232448	C	C	21232448	3	2	166	1	0	0	0	0	1	0	0	0	785	1435	50	4	6415	4	APOB	2	21232448	Missense_Mutation	SNP	T	TCGA-19-5953-01B-12D-1845-08		21232448	221966925	17	11802											
SLC9A4	389015	broad.mit.edu	37	chr2	103141556	103141556	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaagagattctgatccgccGccagaacaccttaagggaga	10	10	1	4			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr2:103141556G>A	uc002tbz.3	+	10	2349	c.1892G>A	c.(1891-1893)CGC>CAC	p.R631H		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	631	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CTGATCCGCCGCCAGAACACC	0.507													A	103141556	A	A	103141556	3	1	166	1	0	0	0	0	1	0	0	0	14716	1087	38	1	1930	1	SLC9A4	2	103141556	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	81909108	103141556	140057817	18	11803											
EEFSEC	60678	broad.mit.edu	37	chr3	127981028	127981028	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggggggaccagaggccccCgaaactgaagctccacaggg	15	14	0	2			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr3:127981028C>T	uc003eki.2	+	3	620	c.582C>T	c.(580-582)CCC>CCT	p.P194P	EEFSEC_uc003ekj.2_Silent_p.P194P	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	194						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						CAGAGGCCCCCGAAACTGAAG	0.562													T	127981028	T	T	127981028	2	4	166	1	0	0	0	0	0	0	0	1	4931	639	23	2		2	EEFSEC	3	127981028	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08		127981028	70041402	19	11804											
INTU	27152	broad.mit.edu	37	chr4	128564761	128564761	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtgaggatgaagaagaaagcCtccttcctgagacaccaact	10	10	0	5			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr4:128564761C>G	uc003ifk.1	+	2	302	c.232C>G	c.(232-234)CTC>GTC	p.L78V	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	78										ovary(1)	1						AGAAGAAAGCCTCCTTCCTGA	0.393													G	128564761	G	G	128564761	3	3	166	1	0	0	0	0	1	0	0	0	7786	681	24	5	238	5	INTU	4	128564761	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08		128564761	62589515	20	11805											
ELOVL7	79993	broad.mit.edu	37	chr5	60060144	60060144	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacttggctatttttcttgcGcagaacaaaaaagatctgaa	7	8	2	3			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr5:60060144G>A	uc003jsi.3	-	7	609	c.409C>T	c.(409-411)CGC>TGC	p.R137C	ELOVL7_uc011cqo.1_Missense_Mutation_p.R50C|ELOVL7_uc010iwk.2_Missense_Mutation_p.R137C|ELOVL7_uc003jsj.3_Missense_Mutation_p.R124C	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	137					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				TTTTTCTTGCGCAGAACAAAA	0.348													A	60060144	A	A	60060144	3	1	166	1	0	0	0	0	1	0	0	0	5079	1087	38	1	448	1	ELOVL7	5	60060144	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08		60060144	120855116	21	11806											
PCDHGA3	56112	broad.mit.edu	37	chr5	140725076	140725076	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcatcacttatgcattgacCgaggacactctccagggggc	11	13	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr5:140725076C>T	uc003ljm.1	+	1	1476	c.1476C>T	c.(1474-1476)ACC>ACT	p.T492T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.T252T|PCDHGA3_uc011dap.1_Silent_p.T492T	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	492	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCATTGACCGAGGACACTC	0.542													T	140725076	T	T	140725076	2	4	166	1	0	0	0	0	0	0	0	1	11555	639	23	2		2	PCDHGA3	5	140725076	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	80664932	140725076	40190184	22	11807											
PCDHGA6	56109	broad.mit.edu	37	chr5	140755737	140755737	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactctgtacctggtggtggCggtggccgcggtctcctgcg	16	13	2	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr5:140755737C>T	uc003ljy.1	+	1	2087	c.2087C>T	c.(2086-2088)GCG>GTG	p.A696V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.A696V	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	696	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGTGGTGGCGGTGGCCGCG	0.672													T	140755737	T	T	140755737	3	4	166	1	0	0	0	0	1	0	0	0	11558	768	27	1	2089	1	PCDHGA6	5	140755737	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	30661	140755737	40159523	23	11808											
FAT2	2196	broad.mit.edu	37	chr5	150942915	150942915	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtgaatcataaagaatcccAtgtagttcccactggtgatg	10	8	1	3			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr5:150942915A>G	uc003lue.3	-	2	3558	c.3545T>C	c.(3544-3546)ATG>ACG	p.M1182T	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.M1182T	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1182	Extracellular (Potential).|Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAGAATCCCATGTAGTTCCC	0.438													G	150942915	G	G	150942915	3	3	166	1	0	0	0	0	1	0	0	0	5690	217	8	4	9592	4	FAT2	5	150942915	Missense_Mutation	SNP	A	TCGA-19-5953-01B-12D-1845-08	10187178	150942915	29972345	24	11809											
LARP1	23367	broad.mit.edu	37	chr5	154135677	154135677	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggacttcgtggaagccccCccgcccaaggtgaacccgtg	13	16	0	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr5:154135677C>T	uc003lvp.2	+	1	789	c.360C>T	c.(358-360)CCC>CCT	p.P120P	LARP1_uc003lvo.2_Intron|LARP1_uc010jie.1_5'Flank	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	120							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGGAAGCCCCCCCGCCCAAGG	0.627													T	154135677	T	T	154135677	2	4	166	1	0	0	0	0	0	0	0	1	8628	638	22	3		3	LARP1	5	154135677	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	3192762	154135677	26779583	25	11810											
GPR116	221395	broad.mit.edu	37	chr6	46826522	46826522	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agtccggttcttggtcaccgAtttccacaccacagcttcca	7	15	2	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr6:46826522A>T	uc003oyo.3	-	17	3407	c.3118T>A	c.(3118-3120)TCG>ACG	p.S1040T	GPR116_uc011dwj.1_Missense_Mutation_p.S595T|GPR116_uc011dwk.1_Missense_Mutation_p.S469T|GPR116_uc003oyp.3_Missense_Mutation_p.S898T|GPR116_uc003oyq.3_Missense_Mutation_p.S1040T|GPR116_uc010jzi.1_Missense_Mutation_p.S712T	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1040	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			TTGGTCACCGATTTCCACACC	0.507													T	46826522	T	T	46826522	3	4	166	1	0	0	0	0	1	0	0	0	6633	333	12	5	942	5	GPR116	6	46826522	Missense_Mutation	SNP	A	TCGA-19-5953-01B-12D-1845-08		46826522	124288545	26	11811											
MANEA	79694	broad.mit.edu	37	chr6	96054014	96054014	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggaacacgcaaaacactcgGaaccgaatcaatgggaagta	10	9	1	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr6:96054014G>A	uc003poo.1	+	5	1262	c.1122G>A	c.(1120-1122)CGG>CGA	p.R374R		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	374	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		AAAACACTCGGAACCGAATCA	0.408													A	96054014	A	A	96054014	2	1	166	1	0	0	0	0	0	0	0	1	9221	1161	41	3		3	MANEA	6	96054014	Silent	SNP	G	TCGA-19-5953-01B-12D-1845-08	49227492	96054014	75061053	27	11812											
SLC22A16	85413	broad.mit.edu	37	chr6	110768146	110768146	+	Frame_Shift_Del	DEL	A	-	-													acgccgctgctattccaaacAaaaacatgctactgcttgtg							TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr6:110768146delA	uc003puf.2	-	3	648	c.581delT	c.(580-582)TTGfs	p.L194fs	SLC22A16_uc003pue.2_Frame_Shift_Del_p.L175fs	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	194	Helical; (Potential).				acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		TATTCCAAACAAAAACATGCT	0.433													-	110768146	-	-	110768146	7	5	166	1	0	1	0	1	0	0	0	0	14447	131	5	0	1176	0	SLC22A16	6	110768146	Frame_Shift_Del	DEL	A	TCGA-19-5953-01B-12D-1845-08	14714132	110768146	60346921	28	11813											
OLIG3	167826	broad.mit.edu	37	chr6	137815222	137815222	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggctctcctggtggtggtggTggcggtggtggtggtccctc	20	9	1	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr6:137815222T>C	uc003qhp.1	-	1	310	c.86A>G	c.(85-87)CAC>CGC	p.H29R		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	29	Poly-His.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		gtggtggtggtggcggtggtg	0.483													C	137815222	C	C	137815222	3	2	166	1	0	0	0	0	1	0	0	0	10862	1696	59	4	736	4	OLIG3	6	137815222	Missense_Mutation	SNP	T	TCGA-19-5953-01B-12D-1845-08	27047076	137815222	33299845	29	11814											
REPS1	85021	broad.mit.edu	37	chr6	139266737	139266737	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggggaattacaccagaataCgacccttgattttcagaatc	9	9	1	3			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr6:139266737C>T	uc003qii.2	-	3	954	c.375G>A	c.(373-375)TCG>TCA	p.S125S	REPS1_uc003qig.3_Silent_p.S125S|REPS1_uc011edr.1_Silent_p.S125S|REPS1_uc003qij.2_Silent_p.S125S|REPS1_uc003qik.2_5'UTR	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	125						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		CACCAGAATACGACCCTTGAT	0.483													T	139266737	T	T	139266737	2	4	166	1	0	0	0	0	0	0	0	1	13228	523	19	1		1	REPS1	6	139266737	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	1451515	139266737	31848330	30	11815											
PCLO	27445	broad.mit.edu	37	chr7	82580167	82580167	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccatgatcttttcttgttctCggaacctttgaatttcctga	6	10	3	3			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr7:82580167C>T	uc003uhx.2	-	6	10026	c.9737G>A	c.(9736-9738)CGA>CAA	p.R3246Q	PCLO_uc003uhv.2_Missense_Mutation_p.R3246Q|PCLO_uc010lec.2_Missense_Mutation_p.R211Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3177	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTCTTGTTCTCGGAACCTTTG	0.473													T	82580167	T	T	82580167	3	4	166	1	0	0	0	0	1	0	0	0	11583	884	31	2	5788	2	PCLO	7	82580167	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08		82580167	76558496	31	11816											
ABCB1	5243	broad.mit.edu	37	chr7	87174224	87174224	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	atctttttcttattagactgGatcttgaatcatttgaagac	6	6	4	4			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr7:87174224G>C	uc003uiz.1	-	17	2397	c.1979C>G	c.(1978-1980)TCC>TGC	p.S660C	ABCB1_uc011khc.1_Missense_Mutation_p.S596C	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	660	Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TATTAGACTGGATCTTGAATC	0.388													C	87174224	C	C	87174224	3	2	166	1	0	0	0	0	1	0	0	0	40	1174	41	5	1915	5	ABCB1	7	87174224	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	4594057	87174224	71964439	32	11817											
COL1A2	1278	broad.mit.edu	37	chr7	94039107	94039107	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggccctgttggtgctgccGgtgctactggtgccagagga	16	11	0	1	rs67865220		TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr7:94039107G>A	uc003ung.1	+	19	1480	c.1009G>A	c.(1009-1011)GGT>AGT	p.G337S	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	337			G -> S (in OI3).|G -> C (in OI3).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGGTGCTGCCGGTGCTACTGG	0.557										HNSCC(75;0.22)			A	94039107	A	A	94039107	3	1	166	1	0	0	0	0	1	0	0	0	3678	1116	39	2	1083	2	COL1A2	7	94039107	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	6864883	94039107	65099556	33	11818											
C7orf43	55262	broad.mit.edu	37	chr7	99753440	99753440	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggcgctcctcctcacacaGctgctttcctgggggcagaa	11	16	1	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr7:99753440G>A	uc003utr.2	-	9	1429	c.1249C>T	c.(1249-1251)CTG>TTG	p.L417L	C7orf43_uc010lgo.2_Silent_p.L43L|C7orf43_uc010lgp.2_Silent_p.L39L|C7orf43_uc011kjj.1_Silent_p.L185L|C7orf43_uc003uts.2_Silent_p.L148L	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	417											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCCTCACACAGCTGCTTTCCT	0.612													A	99753440	A	A	99753440	2	1	166	1	0	0	0	0	0	0	0	1	2393	962	34	3		3	C7orf43	7	99753440	Silent	SNP	G	TCGA-19-5953-01B-12D-1845-08	5714333	99753440	59385223	34	11819											
ZCWPW1	55063	broad.mit.edu	37	chr7	99998739	99998739	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaacatcttccatgagttgCtccaggtccaggtcactgga	9	13	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr7:99998739C>T	uc003uut.2	-	18	2093	c.1845G>A	c.(1843-1845)GAG>GAA	p.E615E	ZCWPW1_uc011kjq.1_Silent_p.E495E|ZCWPW1_uc003uur.2_3'UTR|ZCWPW1_uc003uus.2_Silent_p.E444E|ZCWPW1_uc011kjr.1_3'UTR|ZCWPW1_uc011kjp.1_RNA	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	615							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCATGAGTTGCTCCAGGTCCA	0.612													T	99998739	T	T	99998739	2	4	166	1	0	0	0	0	0	0	0	1	17594	796	28	3		3	ZCWPW1	7	99998739	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	245299	99998739	59139924	35	11820											
MUC17	140453	broad.mit.edu	37	chr7	100677675	100677675	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagcacacctgtcagccacaCgctggtggccaattctgagg	11	13	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr7:100677675C>T	uc003uxp.1	+	3	3031	c.2978C>T	c.(2977-2979)ACG>ATG	p.T993M	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	993	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|14.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGCCACACGCTGGTGGCC	0.512													T	100677675	T	T	100677675	3	4	166	1	0	0	0	0	1	0	0	0	9974	536	19	1	2988	1	MUC17	7	100677675	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	678936	100677675	58460988	36	11821											
OR2A25	392138	broad.mit.edu	37	chr7	143772171	143772171	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaatcccatgcttaatcccCtaatttatagtcttaggaac	4	11	2	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr7:143772171C>T	uc011ktx.1	+	1	859	c.859C>T	c.(859-861)CTA>TTA	p.L287L		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GCTTAATCCCCTAATTTATAG	0.413													T	143772171	T	T	143772171	2	4	166	1	0	0	0	0	0	0	0	1	10978	680	24	3		3	OR2A25	7	143772171	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	43094496	143772171	15366492	37	11822											
DEPDC6	64798	broad.mit.edu	37	chr8	121021282	121021282	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctagattgttggtgacgcGgttggctggggttttgtggt	17	5	1	2			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr8:121021282G>A	uc003yow.3	+	8	1198	c.1011G>A	c.(1009-1011)GCG>GCA	p.A337A	DEPDC6_uc011lid.1_Silent_p.A236A	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	337	PDZ.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTGGTGACGCGGTTGGCTGGG	0.542													A	121021282	A	A	121021282	2	1	166	1	0	0	0	0	0	0	0	1	4443	1103	39	2		2	DEPDC6	8	121021282	Silent	SNP	G	TCGA-19-5953-01B-12D-1845-08		121021282	25342740	38	11823											
FAM83H	286077	broad.mit.edu	37	chr8	144808270	144808270	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcatgctctccatgcggcGcagcagccgatcgcgctcct	12	17	1	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr8:144808270G>A	uc003yzk.2	-	5	3430	c.3361C>T	c.(3361-3363)CGC>TGC	p.R1121C	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1121					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TCCATGCGGCGCAGCAGCCGA	0.677													A	144808270	A	A	144808270	3	1	166	1	0	0	0	0	1	0	0	0	5640	1087	38	1	182	1	FAM83H	8	144808270	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	23786988	144808270	1555752	39	11824											
TAF1L	138474	broad.mit.edu	37	chr9	32633525	32633525	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgagatcctgaggtgtgcGcataaaaaacaactctccac	9	10	1	2	rs147409173		TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr9:32633525G>A	uc003zrg.1	-	1	2143	c.2053C>T	c.(2053-2055)CGC>TGC	p.R685C	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	685					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGAGGTGTGCGCATAAAAAAC	0.448													A	32633525	A	A	32633525	3	1	166	1	0	0	0	0	1	0	0	0	15520	1087	38	1	3431	1	TAF1L	9	32633525	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08		32633525	108579906	40	11825											
STRBP	55342	broad.mit.edu	37	chr9	125909182	125909182	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcttggatggtcctgaggcTtcatatgttgtgccatccac	10	10	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr9:125909182T>C	uc004bns.2	-	13	1720	c.1290A>G	c.(1288-1290)GAA>GAG	p.E430E	STRBP_uc004bnt.2_Silent_p.E248E|STRBP_uc004bnu.2_Silent_p.E416E|STRBP_uc004bnv.2_Silent_p.E430E|STRBP_uc004bnr.2_Silent_p.E42E	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	430	DRBM 1.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						GTCCTGAGGCTTCATATGTTG	0.433													C	125909182	C	C	125909182	2	2	166	1	0	0	0	0	0	0	0	1	15326	1606	56	4		4	STRBP	9	125909182	Silent	SNP	T	TCGA-19-5953-01B-12D-1845-08	93275657	125909182	15304249	41	11826											
PTEN	5728	broad.mit.edu	37	chr10	89692893	89692893	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagcaattcactgtaaagCtggaaagggacgaactggtg	13	7	1	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr10:89692893C>T	uc001kfb.2	+	6	1408	c.377C>T	c.(376-378)GCT>GTT	p.A126V		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	126	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.A126T(5)|p.R55fs*1(4)|p.A126D(3)|p.?(2)|p.Y27fs*1(2)|p.A126P(2)|p.Y27_N212>Y(2)|p.A121_F145del(1)|p.A126V(1)|p.A126S(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CACTGTAAAGCTGGAAAGGGA	0.408		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89692893	T	T	89692893	3	4	166	1	0	0	0	0	1	0	0	0	12738	797	28	3	395	3	PTEN	10	89692893	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08		89692893	45841854	42	11827											
PDE3B	5140	broad.mit.edu	37	chr11	14839801	14839801	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tactggctctctaactaatcGatcacccatagaatttcctg	5	12	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr11:14839801G>A	uc001mln.2	+	6	1948	c.1595G>A	c.(1594-1596)CGA>CAA	p.R532Q	PDE3B_uc010rcr.1_Missense_Mutation_p.R481Q	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	532					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						CTAACTAATCGATCACCCATA	0.388													A	14839801	A	A	14839801	3	1	166	1	0	0	0	0	1	0	0	0	11638	1058	37	2	1617	2	PDE3B	11	14839801	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08		14839801	120166715	43	11828											
OR5T3	390154	broad.mit.edu	37	chr11	56020021	56020021	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaaaatgttggtcaatttcCtggcaaaaaataaatccatt	5	7	1	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr11:56020021C>T	uc010rjd.1	+	1	346	c.346C>T	c.(346-348)CTG>TTG	p.L116L		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	116	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					GGTCAATTTCCTGGCAAAAAA	0.368													T	56020021	T	T	56020021	2	4	166	1	0	0	0	0	0	0	0	1	11183	680	24	3		3	OR5T3	11	56020021	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	41180220	56020021	78986495	44	11829											
SHANK2	22941	broad.mit.edu	37	chr11	70319235	70319235	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagtatcgagggggatggCgacctactgcgtcccgctgg	16	11	0	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr11:70319235C>T	uc001oqc.2	-	22	5367	c.5289G>A	c.(5287-5289)TCG>TCA	p.S1763S	SHANK2_uc010rqn.1_Silent_p.S1175S|SHANK2_uc001opz.2_Silent_p.S1168S|uc009ysn.1_Silent_p.G45G|SHANK2_uc001opy.2_Silent_p.S99S	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1384					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AGGGGGATGGCGACCTACTGC	0.537													T	70319235	T	T	70319235	2	4	166	1	0	0	0	0	0	0	0	1	14265	755	27	1		1	SHANK2	11	70319235	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	14299214	70319235	64687281	45	11830											
KRTAP5-10	387273	broad.mit.edu	37	chr11	71276821	71276910	+	In_Frame_Del	DEL	GCTGTGGCTCCTGTGGGGGCTCCAAGGGGGACTGTGGCTCTTGTGGGGGCTCCAAAGGGGGCTGTGGTTCCTGTGGGGGCTCCAAGGGGG	-	-													gccagcctgttcctgctccaGctgtggctcctgtgggggct					rs146095815	by1000genomes	TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr11:71276821_71276910delGCTGTGGCTCCTGTGGGGGCTCCAAGGGGGACTGTGGCTCTTGTGGGGGCTCCAAAGGGGGCTGTGGTTCCTGTGGGGGCTCCAAGGGGG	uc001oqt.1	+	1	213_302	c.188_277delGCTGTGGCTCCTGTGGGGGCTCCAAGGGGGACTGTGGCTCTTGTGGGGGCTCCAAAGGGGGCTGTGGTTCCTGTGGGGGCTCCAAGGGGG	c.(187-279)AGCTGTGGCTCCTGTGGGGGCTCCAAGGGGGACTGTGGCTCTTGTGGGGGCTCCAAAGGGGGCTGTGGTTCCTGTGGGGGCTCCAAGGGGGGC>AGC	p.CGSCGGSKGDCGSCGGSKGGCGSCGGSKGG64del		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	64_93	7 X 4 AA repeats of C-C-X-P.					keratin filament		p.G65S(1)		skin(1)	1						TCCTGCTCCAGCTGTGGCTCCTGTGGGGGCTCCAAGGGGGACTGTGGCTCTTGTGGGGGCTCCAAAGGGGGCTGTGGTTCCTGTGGGGGCTCCAAGGGGGGCTGTGGCTC	0.676													-	71276910	-	-	71276821	7	5	166	1	0	1	0	1	0	0	0	0	8559	971	34	0	190	0	KRTAP5-10	11	71276821	In_Frame_Del	DEL	GCTGTGGCTCCTGTGGGGGCTCCAAGGGGGACTGTGGCTCTTGTGGGGGCTCCAAAGGGGGCTGTGGTTCCTGTGGGGGCTCCAAGGGGG	TCGA-19-5953-01B-12D-1845-08	957586	71276821	63729695	46	11831											
SLCO2B1	11309	broad.mit.edu	37	chr11	74876887	74876887	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttttggcagccgggtgcaccGaccccgaatgattggctatg	13	11	0	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr11:74876887G>A	uc001owb.2	+	4	728	c.341G>A	c.(340-342)CGA>CAA	p.R114Q	SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Intron|SLCO2B1_uc010rrs.1_5'UTR|SLCO2B1_uc001owc.2_5'UTR|SLCO2B1_uc001owd.2_Missense_Mutation_p.R92Q	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	114	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	CGGGTGCACCGACCCCGAATG	0.572													A	74876887	A	A	74876887	3	1	166	1	0	0	0	0	1	0	0	0	14727	1058	37	2	355	2	SLCO2B1	11	74876887	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	3600066	74876887	60129629	47	11832											
DRD2	1813	broad.mit.edu	37	chr11	113286210	113286210	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtgttgactcgcttgcggCgtctgcggaggacaatgtag	16	8	1	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr11:113286210C>T	uc001pnz.2	-	4	977	c.656G>A	c.(655-657)CGC>CAC	p.R219H	DRD2_uc010rwv.1_Missense_Mutation_p.R218H|DRD2_uc001poa.3_Missense_Mutation_p.R219H|DRD2_uc001pob.3_Missense_Mutation_p.R219H|DRD2_uc009yyr.1_Missense_Mutation_p.R219H	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	219	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	TCGCTTGCGGCGTCTGCGGAG	0.572													T	113286210	T	T	113286210	3	4	166	1	0	0	0	0	1	0	0	0	4757	768	27	1	691	1	DRD2	11	113286210	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	38409323	113286210	21720306	48	11833											
GDF3	9573	broad.mit.edu	37	chr12	7842975	7842975	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtatctccaggaataacccGaaatttttccgggggttgtc	10	9	1	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr12:7842975G>A	uc001qte.2	-	2	630	c.594C>T	c.(592-594)TTC>TTT	p.F198F		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	198					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						GGAATAACCCGAAATTTTTCC	0.473													A	7842975	A	A	7842975	2	1	166	1	0	0	0	0	0	0	0	1	6315	1049	37	2		2	GDF3	12	7842975	Silent	SNP	G	TCGA-19-5953-01B-12D-1845-08		7842975	126008920	49	11834											
ERP27	121506	broad.mit.edu	37	chr12	15070213	15070213	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggagatgaatctgaattaCgctgttgaataacccaatca	9	7	2	4	rs139573344	byFrequency	TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr12:15070213C>T	uc001rco.2	-	5	496	c.475G>A	c.(475-477)GTA>ATA	p.V159I		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	159						endoplasmic reticulum lumen				breast(1)	1						ATCTGAATTACGCTGTTGAAT	0.453													T	15070213	T	T	15070213	3	4	166	1	0	0	0	0	1	0	0	0	5241	536	19	1	358	1	ERP27	12	15070213	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	7227238	15070213	118781682	50	11835											
CPSF6	11052	broad.mit.edu	37	chr12	69645041	69645041	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caactgttggtgatgatgtgGgtaaaggagcagcaccaaat	13	6	0	2			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr12:69645041G>C	uc001sut.3	+	2	303	c.193G>C	c.(193-195)GGT>CGT	p.G65R	CPSF6_uc001suu.3_Missense_Mutation_p.G65R	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	65					mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			TGATGATGTGGGTAAAGGAGC	0.378													C	69645041	C	C	69645041	3	2	166	1	0	0	0	0	1	0	0	0	3829	1232	43	5	199	5	CPSF6	12	69645041	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	54574828	69645041	64206854	51	11836											
KIAA1033	23325	broad.mit.edu	37	chr12	105514968	105514968	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	atcacactgaaagaccactgGactatgtacaaaaggtacac	7	10	1	2			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr12:105514968G>T	uc001tld.2	+	9	738	c.651G>T	c.(649-651)TGG>TGT	p.W217C	KIAA1033_uc010swr.1_Missense_Mutation_p.W217C|KIAA1033_uc010sws.1_Missense_Mutation_p.W29C	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	217					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						AAGACCACTGGACTATGTACA	0.299													T	105514968	T	T	105514968	3	4	166	1	0	0	0	0	1	0	0	0	8206	1183	41	5	685	5	KIAA1033	12	105514968	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	35869927	105514968	28336927	52	11837											
WSCD2	9671	broad.mit.edu	37	chr12	108603905	108603905	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagcctcccccaggggttacCtgtatggcgggctggagttc	14	13	0	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr12:108603905C>A	uc001tms.2	+	4	1249	c.505C>A	c.(505-507)CTG>ATG	p.L169M	WSCD2_uc001tmt.2_Missense_Mutation_p.L169M	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	169	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						CAGGGGTTACCTGTATGGCGG	0.647													A	108603905	A	A	108603905	3	1	166	1	0	0	0	0	1	0	0	0	17404	680	24	5	515	5	WSCD2	12	108603905	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	3088937	108603905	25247990	53	11838											
TMEM132D	121256	broad.mit.edu	37	chr12	129563144	129563144	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatggccctgttgcttcctgGgctgagctgcaaggagagtg	16	9	0	2			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr12:129563144G>A	uc009zyl.1	-	8	2378	c.2050C>T	c.(2050-2052)CCA>TCA	p.P684S	TMEM132D_uc001uia.2_Missense_Mutation_p.P222S	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	684	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTGCTTCCTGGGCTGAGCTGC	0.577													A	129563144	A	A	129563144	3	1	166	1	0	0	0	0	1	0	0	0	16044	1232	43	3	1257	3	TMEM132D	12	129563144	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	20959239	129563144	4288751	54	11839											
ANKLE2	23141	broad.mit.edu	37	chr12	133306704	133306704	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ggcttctatgaggtctgcctCctgctccaaggggaaggcgc	14	12	2	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr12:133306704C>G	uc001ukx.2	-	11	2111	c.2044G>C	c.(2044-2046)GAG>CAG	p.E682Q	ANKLE2_uc009zyw.1_Missense_Mutation_p.E37Q	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	682						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		AGGTCTGCCTCCTGCTCCAAG	0.572													G	133306704	G	G	133306704	3	3	166	1	0	0	0	0	1	0	0	0	633	864	30	5	784	5	ANKLE2	12	133306704	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	3743560	133306704	545191	55	11840											
SLC39A2	29986	broad.mit.edu	37	chr14	21469493	21469493	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgggcagtgttctccataCtattattagctctcatgtcc	8	10	2	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr14:21469493C>T	uc001vyr.2	+	4	872	c.685C>T	c.(685-687)CTA>TTA	p.L229L	SLC39A2_uc001vys.2_Silent_p.L130L	NM_014579	NP_055394	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter),	229	Helical; (Potential).					cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			ovary(2)|central_nervous_system(1)	3	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		GTTCTCCATACTATTATTAGC	0.567													T	21469493	T	T	21469493	2	4	166	1	0	0	0	0	0	0	0	1	14618	564	20	3		3	SLC39A2	14	21469493	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08		21469493	85880047	56	11841											
C15orf2	23742	broad.mit.edu	37	chr15	24921103	24921103	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcccccgctcccctgtcccGggacgcctccccgcccggtc	10	25	0	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr15:24921103G>A	uc001ywo.2	+	1	563	c.89G>A	c.(88-90)CGG>CAG	p.R30Q		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	30					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCCCTGTCCCGGGACGCCTCC	0.706													A	24921103	A	A	24921103	3	1	166	1	0	0	0	0	1	0	0	0	1784	1116	39	2	91	2	C15orf2	15	24921103	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08		24921103	77610289	57	11842											
CHRNB4	1143	broad.mit.edu	37	chr15	78917630	78917630	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgtacttccagtcctcaaCgacctgcaggcagacagagg	10	14	1	2			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr15:78917630C>T	uc002bed.1	-	6	1454	c.1342G>A	c.(1342-1344)GTT>ATT	p.V448I	CHRNB4_uc002bee.1_Silent_p.S121S|uc002bef.1_5'Flank	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	448	Cytoplasmic (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						CAGTCCTCAACGACCTGCAGG	0.607													T	78917630	T	T	78917630	3	4	166	1	0	0	0	0	1	0	0	0	3393	536	19	1	158	1	CHRNB4	15	78917630	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	53996527	78917630	23613762	58	11843											
CHRNB4	1143	broad.mit.edu	37	chr15	78922161	78922161	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agggtgcagttctgctggtcGaagggaaagtacttcacctc	13	9	2	0	rs80249872		TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr15:78922161G>A	uc002bed.1	-	5	598	c.486C>T	c.(484-486)TTC>TTT	p.F162F	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_5'UTR	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	162	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						TCTGCTGGTCGAAGGGAAAGT	0.552													A	78922161	A	A	78922161	2	1	166	1	0	0	0	0	0	0	0	1	3393	1049	37	2		2	CHRNB4	15	78922161	Silent	SNP	G	TCGA-19-5953-01B-12D-1845-08	4531	78922161	23609231	59	11844											
SEPT12	124404	broad.mit.edu	37	chr16	4833669	4833669	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccctgcgcctgaaggcctctCgctcctccatggtcaggctg	11	17	2	1	rs140969211		TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr16:4833669C>T	uc002cxq.2	-	6	752	c.611G>A	c.(610-612)CGA>CAA	p.R204Q	SEPT12_uc002cxr.2_Missense_Mutation_p.R158Q|SEPT12_uc010bty.2_RNA	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	204					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						GAAGGCCTCTCGCTCCTCCAT	0.677													T	4833669	T	T	4833669	3	4	166	1	0	0	0	0	1	0	0	0	14062	884	31	2	485	2	SEPT12	16	4833669	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08		4833669	85521084	60	11845											
ITGAD	3681	broad.mit.edu	37	chr16	31435264	31435264	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgaagggcaatctcagtttCggctgggtccgcgaggtgtg	16	9	1	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr16:31435264C>T	uc002ebv.1	+	27	3193	c.3144C>T	c.(3142-3144)TTC>TTT	p.F1048F	ITGAD_uc010cap.1_Silent_p.F1049F	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	1048	Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						ATCTCAGTTTCGGCTGGGTCC	0.642													T	31435264	T	T	31435264	2	4	166	1	0	0	0	0	0	0	0	1	7884	883	31	2		2	ITGAD	16	31435264	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	26601595	31435264	58919489	61	11846											
C16orf78	123970	broad.mit.edu	37	chr16	49407930	49407930	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagactgctgaagataggcGcatgtctgacctcacctgtg	12	10	2	4	rs144505396	byFrequency	TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr16:49407930G>A	uc002efr.2	+	1	123	c.80G>A	c.(79-81)CGC>CAC	p.R27H		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	27										central_nervous_system(1)	1						GAAGATAGGCGCATGTCTGAC	0.488													A	49407930	A	A	49407930	3	1	166	1	0	0	0	0	1	0	0	0	1835	1087	38	1	82	1	C16orf78	16	49407930	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	17972666	49407930	40946823	62	11847											
NF1	4763	broad.mit.edu	37	chr17	29588751	29588751	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcataaagctgttggaagaCgaccttttgataagatggca	10	6	1	3			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr17:29588751C>T	uc002hgg.2	+	35	4933	c.4600C>T	c.(4600-4602)CGA>TGA	p.R1534*	NF1_uc002hgh.2_Nonsense_Mutation_p.R1513*|NF1_uc002hgi.1_Nonsense_Mutation_p.R546*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1534					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(3)|p.R1534*(3)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGTTGGAAGACGACCTTTTGA	0.413			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29588751	T	T	29588751	4	4	166	1	0	0	0	0	0	1	0	0	10356	528	19	1	4799	1	NF1	17	29588751	Nonsense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08		29588751	51606459	63	11848											
KRT25	147183	broad.mit.edu	37	chr17	38904633	38904633	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttaaccactatggctttggCtgggtctgagcattaaaaat	9	8	1	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr17:38904633C>T	uc002hve.2	-	8	1310	c.1249G>A	c.(1249-1251)GCC>ACC	p.A417T		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	417	Tail.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				ATGGCTTTGGCTGGGTCTGAG	0.348													T	38904633	T	T	38904633	3	4	166	1	0	0	0	0	1	0	0	0	8462	797	28	3	107	3	KRT25	17	38904633	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	9315882	38904633	42290577	64	11849											
RAD51C	5889	broad.mit.edu	37	chr17	56809897	56809897	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aggaatgcacagtactgtttCaaatcaaagtcagtattatt	7	6	3	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr17:56809897C>G	uc002iwu.2	+	8	1060	c.1018C>G	c.(1018-1020)CAA>GAA	p.Q340E	RAD51C_uc010woa.1_Missense_Mutation_p.Q340E|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	340					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGTACTGTTTCAAATCAAAGT	0.338								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				G	56809897	G	G	56809897	3	3	166	1	0	0	0	0	1	0	0	0	12988	827	29	5	1052	5	RAD51C	17	56809897	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	17905264	56809897	24385313	65	11850											
BAHCC1	57597	broad.mit.edu	37	chr17	79412126	79412126	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atgcagcacccgggccagctCcctgtgtactcgaggccgca	12	16	0	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr17:79412126C>T	uc002kaf.2	+	7	2757	c.2757C>T	c.(2755-2757)CTC>CTT	p.L919L	BAHCC1_uc002kae.2_Silent_p.L118L	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	919	Pro-rich.						DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CGGGCCAGCTCCCTGTGTACT	0.697													T	79412126	T	T	79412126	2	4	166	1	0	0	0	0	0	0	0	1	1296	842	30	3		3	BAHCC1	17	79412126	Silent	SNP	C	TCGA-19-5953-01B-12D-1845-08	22602229	79412126	1783084	66	11851											
LAMA1	284217	broad.mit.edu	37	chr18	7011448	7011448	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttactctgagaaaccacacGcagaagaggctgatcggagc	12	10	1	4			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr18:7011448G>A	uc002knm.2	-	25	3632	c.3538C>T	c.(3538-3540)CGT>TGT	p.R1180C	LAMA1_uc010wzj.1_Missense_Mutation_p.R656C	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1180	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAACCACACGCAGAAGAGGC	0.552													A	7011448	A	A	7011448	3	1	166	1	0	0	0	0	1	0	0	0	8605	1087	38	1	5845	1	LAMA1	18	7011448	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08		7011448	71065800	67	11852											
MIB1	57534	broad.mit.edu	37	chr18	19358097	19358097	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtccaggatgccaagggaGgttctttctacagagatcac	12	9	3	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr18:19358097G>A	uc002ktq.2	+	5	670	c.670G>A	c.(670-672)GGT>AGT	p.G224S	MIB1_uc002ktp.2_5'UTR	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	224					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			TGCCAAGGGAGGTTCTTTCTA	0.403													A	19358097	A	A	19358097	3	1	166	1	0	0	0	0	1	0	0	0	9566	1000	35	3	688	3	MIB1	18	19358097	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	12346649	19358097	58719151	68	11853											
DSG3	1830	broad.mit.edu	37	chr18	29039054	29039054	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagaaaccacttatactaaCggttaaaattttggatatta	6	5	0	1	rs62095186		TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr18:29039054C>T	uc002kws.2	+	5	540	c.431C>T	c.(430-432)ACG>ATG	p.T144M		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	144	Extracellular (Potential).|Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTTATACTAACGGTTAAAATT	0.358													T	29039054	T	T	29039054	3	4	166	1	0	0	0	0	1	0	0	0	4778	536	19	1	449	1	DSG3	18	29039054	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08	9680957	29039054	49038194	69	11854											
COL6A1	1291	broad.mit.edu	37	chr21	47423347	47423347	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcaccatcctgctggacgGctccgccagcgtgggcagcc	12	17	1	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr21:47423347G>A	uc002zhu.1	+	35	2609	c.2507G>A	c.(2506-2508)GGC>GAC	p.G836D	COL6A1_uc010gqd.1_Missense_Mutation_p.G167D|COL6A1_uc002zhv.1_Missense_Mutation_p.G167D|COL6A1_uc002zhw.1_5'UTR	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	836	C-terminal globular domain.|VWFA 3.			DGSAS -> EPPPD (in Ref. 1; CAA33889).	axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CTGCTGGACGGCTCCGCCAGC	0.692													A	47423347	A	A	47423347	3	1	166	1	0	0	0	0	1	0	0	0	3699	1203	42	3	2645	3	COL6A1	21	47423347	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08		47423347	706548	70	11855											
SLC5A4	6527	broad.mit.edu	37	chr22	32628993	32628993	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttcacgtgagacatgtccTtgccacacaggcagcgctgc	10	15	1	1			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chr22:32628993T>G	uc003ami.2	-	9	916	c.914A>C	c.(913-915)AAG>ACG	p.K305T		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	305	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						AGACATGTCCTTGCCACACAG	0.557													G	32628993	G	G	32628993	3	3	166	1	0	0	0	0	1	0	0	0	14667	1609	56	5	1093	5	SLC5A4	22	32628993	Missense_Mutation	SNP	T	TCGA-19-5953-01B-12D-1845-08		32628993	18675573	71	11856											
FAM47A	158724	broad.mit.edu	37	chrX	34150044	34150044	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggcttccacttgctctaCgaacgccttccgtgctagct	9	15	1	0			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chrX:34150044C>T	uc004ddg.2	-	1	385	c.352G>A	c.(352-354)GTA>ATA	p.V118I		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	118										ovary(4)|central_nervous_system(1)	5						ACTTGCTCTACGAACGCCTTC	0.547													T	34150044	T	T	34150044	3	4	166	1	0	0	0	0	1	0	0	0	5569	536	19	1	2027	1	FAM47A	23	34150044	Missense_Mutation	SNP	C	TCGA-19-5953-01B-12D-1845-08		34150044	121120516	72	11857											
ZNF711	7552	broad.mit.edu	37	chrX	84526085	84526085	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgtgttgagtgtgggaagGgttttcgacatccttctgaa	13	5	1	2			TCGA-19-5953-01B-12D-1845-08	TCGA-19-5953-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a0180465-3685-4735-a76e-acbeebfa635a	ee331f5d-4cef-4c7e-9c0e-16efd5ff3417	g.chrX:84526085G>A	uc004eeo.2	+	9	1884	c.1537G>A	c.(1537-1539)GGT>AGT	p.G513S	ZNF711_uc004eep.2_Missense_Mutation_p.G513S|ZNF711_uc004eeq.2_Missense_Mutation_p.G559S|ZNF711_uc011mqy.1_Missense_Mutation_p.G112S	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	513	C2H2-type 4.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						GTGTGGGAAGGGTTTTCGACA	0.413													A	84526085	A	A	84526085	3	1	166	1	0	0	0	0	1	0	0	0	18113	1232	43	3	1563	3	ZNF711	23	84526085	Missense_Mutation	SNP	G	TCGA-19-5953-01B-12D-1845-08	50376041	84526085	70744475	73	11858											
GABRD	2563	broad.mit.edu	37	chr1	1961508	1961508	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctcccgccggcagcgccgCgtcccggggaacctgatggg	15	16	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:1961508C>T	uc001aip.2	+	9	1241	c.1146C>T	c.(1144-1146)CGC>CGT	p.R382R		NM_000815	NP_000806	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	382	Cytoplasmic (Probable).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GGCAGCGCCGCGTCCCGGGGA	0.692													T	1961508	T	T	1961508	2	4	167	1	0	0	0	0	0	0	0	1	6169	755	27	1		1	GABRD	1	1961508	Silent	SNP	C	TCGA-19-5954-01A-11D-1696-08		1961508	247289113	1	11859											
DNAJC11	55735	broad.mit.edu	37	chr1	6704720	6704720	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccgtactccaccaccgtcCcaaagaagcctgctctgcag	7	18	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:6704720C>T	uc001aof.2	-	10	1101	c.995G>A	c.(994-996)GGG>GAG	p.G332E	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Missense_Mutation_p.G332E|DNAJC11_uc010nzu.1_Missense_Mutation_p.G242E	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	332					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CACCACCGTCCCAAAGAAGCC	0.562													T	6704720	T	T	6704720	3	4	167	1	0	0	0	0	1	0	0	0	4630	623	22	3	712	3	DNAJC11	1	6704720	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	4743212	6704720	242545901	2	11860											
TNFRSF9	3604	broad.mit.edu	37	chr1	7998781	7998781	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaatatctttgaactcatacCtttacactgcctgcatatgt	4	10	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:7998781C>A	uc001aot.2	-	3	336	c.208G>T	c.(208-210)GGT>TGT	p.G70C		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,	70	TNFR-Cys 2.|Extracellular (Potential).				induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		GAACTCATACCTTTACACTGC	0.398													A	7998781	A	A	7998781	3	1	167	1	0	0	0	0	1	0	0	0	16297	695	24	5	583	5	TNFRSF9	1	7998781	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	1294061	7998781	241251840	3	11861											
FBLIM1	54751	broad.mit.edu	37	chr1	16095074	16095074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtcccctcaggcccatggagGaagagctgccacctcccccg	11	18	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:16095074G>A	uc001axd.1	+	6	933	c.490G>A	c.(490-492)GAA>AAA	p.E164K	FBLIM1_uc001axe.1_Missense_Mutation_p.E164K|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axg.1_Missense_Mutation_p.E164K|FBLIM1_uc001axh.1_Intron|FBLIM1_uc001axi.1_Intron	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	164	Pro-rich.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		GCCCATGGAGGAAGAGCTGCC	0.652													A	16095074	A	A	16095074	3	1	167	1	0	0	0	0	1	0	0	0	5697	1175	41	3	500	3	FBLIM1	1	16095074	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	8096293	16095074	233155547	4	11862											
C1orf38	9473	broad.mit.edu	37	chr1	28208484	28208484	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctgcccctctccacagtgCgcaggaccattgtcaagatc	9	15	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:28208484C>T	uc001bpc.3	+	4	677	c.649C>T	c.(649-651)CGC>TGC	p.R217C	C1orf38_uc001boz.2_Intron|C1orf38_uc001bpa.2_Intron|C1orf38_uc010ofn.1_Intron|C1orf38_uc010ofo.1_Missense_Mutation_p.R217C	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	217	CABIT 1.				cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCACAGTGCGCAGGACCAT	0.652													T	28208484	T	T	28208484	3	4	167	1	0	0	0	0	1	0	0	0	2039	768	27	1	663	1	C1orf38	1	28208484	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	12113410	28208484	221042137	5	11863											
FLG	2312	broad.mit.edu	37	chr1	152276552	152276552	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctgtccaccagaggaattctCtgcatgatgagtgcctgatt	10	10	1	4			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:152276552C>T	uc001ezu.1	-	3	10846	c.10810G>A	c.(10810-10812)GAG>AAG	p.E3604K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3604	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGAATTCTCTGCATGATGA	0.562									Ichthyosis				T	152276552	T	T	152276552	3	4	167	1	0	0	0	0	1	0	0	0	5922	922	32	3	1379	3	FLG	1	152276552	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	124068068	152276552	96974069	6	11864											
FLG	2312	broad.mit.edu	37	chr1	152280440	152280440	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctgtccaccagaggaattctCtgcatgatgagtgcctgatt	10	10	1	4			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:152280440C>T	uc001ezu.1	-	3	6958	c.6922G>A	c.(6922-6924)GAG>AAG	p.E2308K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2308	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGAATTCTCTGCATGATGA	0.562									Ichthyosis				T	152280440	T	T	152280440	3	4	167	1	0	0	0	0	1	0	0	0	5922	922	32	3	5267	3	FLG	1	152280440	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	3888	152280440	96970181	7	11865											
SEC16B	89866	broad.mit.edu	37	chr1	177936906	177936906	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccctggcctggatgcataatGgggctgctgctgatggtctg	15	10	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:177936906G>T	uc001gli.1	-	2	301	c.211C>A	c.(211-213)CAT>AAT	p.H71N	SEC16B_uc001glk.1_5'UTR|SEC16B_uc009wwz.1_5'UTR|SEC16B_uc001glj.1_Missense_Mutation_p.H71N|SEC16B_uc001gll.3_Missense_Mutation_p.H71N	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	71	Required for endoplasmic reticulum localization.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						GATGCATAATGGGGCTGCTGC	0.542													T	177936906	T	T	177936906	3	4	167	1	0	0	0	0	1	0	0	0	13987	1348	47	5	3071	5	SEC16B	1	177936906	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	25656466	177936906	71313715	8	11866											
LAMB3	3914	broad.mit.edu	37	chr1	209791966	209791966	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccacagggccagcacggcctCgctgacctcctggatagtgg	13	15	0	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:209791966C>T	uc001hhg.2	-	18	3130	c.2740G>A	c.(2740-2742)GAG>AAG	p.E914K	LAMB3_uc009xco.2_Missense_Mutation_p.E914K|LAMB3_uc001hhh.2_Missense_Mutation_p.E914K	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	914	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AGCACGGCCTCGCTGACCTCC	0.582													T	209791966	T	T	209791966	3	4	167	1	0	0	0	0	1	0	0	0	8612	893	31	2	798	2	LAMB3	1	209791966	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	31855060	209791966	39458655	9	11867											
CENPF	1063	broad.mit.edu	37	chr1	214819178	214819178	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagattatgaaaagctgaatGtctccaaggccttggaggcc	11	9	1	3			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr1:214819178G>A	uc001hkm.2	+	13	6439	c.6265G>A	c.(6265-6267)GTC>ATC	p.V2089I		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2185	Potential.|Interaction with NDE1 and NDEL1.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAAGCTGAATGTCTCCAAGGC	0.473													A	214819178	A	A	214819178	3	1	167	1	0	0	0	0	1	0	0	0	3231	1377	48	3	6311	3	CENPF	1	214819178	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	5027212	214819178	34431443	10	11868											
ADCY3	109	broad.mit.edu	37	chr2	25141642	25141642	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagggtctcgtggcgctgcCttttgaagtaggtctggtag	16	8	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr2:25141642C>T	uc002rfs.3	-	1	414	c.215G>A	c.(214-216)AGG>AAG	p.R72K	ADCY3_uc010ykm.1_Missense_Mutation_p.R72K	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	72	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GTGGCGCTGCCTTTTGAAGTA	0.597													T	25141642	T	T	25141642	3	4	167	1	0	0	0	0	1	0	0	0	295	681	24	3	3303	3	ADCY3	2	25141642	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08		25141642	218057731	11	11869											
UXS1	80146	broad.mit.edu	37	chr2	106710571	106710571	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggtactcgagttctttacGgaagtagtgaattgctttgt	11	6	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr2:106710571G>A	uc002tdm.2	-	15	1272	c.1174C>T	c.(1174-1176)CGT>TGT	p.R392C	UXS1_uc002tdk.2_Missense_Mutation_p.R190C|UXS1_uc002tdl.2_Missense_Mutation_p.R224C|UXS1_uc002tdn.2_Missense_Mutation_p.R397C|UXS1_uc002tdo.2_Missense_Mutation_p.R335C	NM_025076	NP_079352	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	392	Lumenal (Potential).				cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2						AGTTCTTTACGGAAGTAGTGA	0.468													A	106710571	A	A	106710571	3	1	167	1	0	0	0	0	1	0	0	0	17106	1116	39	2	92	2	UXS1	2	106710571	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	81568929	106710571	136488802	12	11870											
TUBA3D	113457	broad.mit.edu	37	chr2	132238151	132238151	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgagatcaccaatgcctgCttcgagccagccaatcaaat	8	14	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr2:132238151C>T	uc002tsu.3	+	4	992	c.885C>T	c.(883-885)TGC>TGT	p.C295C		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	295					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CCAATGCCTGCTTCGAGCCAG	0.597													T	132238151	T	T	132238151	2	4	167	1	0	0	0	0	0	0	0	1	16744	805	28	3		3	TUBA3D	2	132238151	Silent	SNP	C	TCGA-19-5954-01A-11D-1696-08	25527580	132238151	110961222	13	11871											
HOXD9	3235	broad.mit.edu	37	chr2	176988850	176988850	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcaaaatctggtttcagaacCgtaggatgaaaatgaaaaag	9	5	3	3			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr2:176988850C>A	uc010zex.1	+	2	1090	c.1006C>A	c.(1006-1008)CGT>AGT	p.R336S		NM_014213	NP_055028	P28356	HXD9_HUMAN	homeobox D9	336	Homeobox.					nucleus	sequence-specific DNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GTTTCAGAACCGTAGGATGAA	0.532													A	176988850	A	A	176988850	3	1	167	1	0	0	0	0	1	0	0	0	7326	652	23	5	1012	5	HOXD9	2	176988850	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	44750699	176988850	66210523	14	11872											
AOX1	316	broad.mit.edu	37	chr2	201478599	201478599	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctcccttttgggctcggcGccaggtgggaaagtggagtt	16	9	1	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr2:201478599G>A	uc002uvx.2	+	15	1622	c.1521G>A	c.(1519-1521)GCG>GCA	p.A507A	AOX1_uc010zhf.1_Silent_p.A63A|AOX1_uc010fsu.2_5'UTR	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	507					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TGGGCTCGGCGCCAGGTGGGA	0.468													A	201478599	A	A	201478599	2	1	167	1	0	0	0	0	0	0	0	1	729	1074	38	1		1	AOX1	2	201478599	Silent	SNP	G	TCGA-19-5954-01A-11D-1696-08	24489749	201478599	41720774	15	11873											
GRIP2	80852	broad.mit.edu	37	chr3	14552933	14552933	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccctacctgtgtgccacgCtgcctttcttgatgtcggag	11	14	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr3:14552933C>T	uc011avi.1	-	16	2069	c.2069G>A	c.(2068-2070)AGC>AAC	p.S690N	GRIP2_uc010heh.2_RNA|GRIP2_uc011avh.1_Missense_Mutation_p.S221N	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	592	PDZ 5.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						GTGTGCCACGCTGCCTTTCTT	0.597													T	14552933	T	T	14552933	3	4	167	1	0	0	0	0	1	0	0	0	6788	797	28	3	1395	3	GRIP2	3	14552933	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08		14552933	183469497	16	11874											
TRIM71	131405	broad.mit.edu	37	chr3	32915463	32915463	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcagatgcccagcagggaCgacaggcaatccaggtgagc	15	11	0	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr3:32915463C>T	uc003cff.2	+	2	1069	c.1006C>T	c.(1006-1008)CGA>TGA	p.R336*		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	336					multicellular organismal development	cytoplasm	zinc ion binding	p.R336fs*6(1)		ovary(2)|large_intestine(1)	3						CCAGCAGGGACGACAGGCAAT	0.612													T	32915463	T	T	32915463	4	4	167	1	0	0	0	0	0	1	0	0	16541	528	19	1	1012	1	TRIM71	3	32915463	Nonsense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	18362530	32915463	165106967	17	11875											
MINA	84864	broad.mit.edu	37	chr3	97686291	97686291	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttgaaaaaagtctctgtcttGatgggcgagattaaactttc	9	6	2	3			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr3:97686291G>T	uc003drz.1	-	2	653	c.147C>A	c.(145-147)ATC>ATA	p.I49I	MINA_uc003dsa.1_Silent_p.I49I|MINA_uc003dsb.1_Silent_p.I49I|MINA_uc003dsc.1_Silent_p.I49I|MINA_uc010hpa.1_RNA|MINA_uc010hpb.1_Intron	NM_001042533	NP_001035998	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen isoform a	49					ribosome biogenesis	cytoplasm|nucleolus				ovary(1)	1						TCTCTGTCTTGATGGGCGAGA	0.488													T	97686291	T	T	97686291	2	4	167	1	0	0	0	0	0	0	0	1	9586	1280	45	5		5	MINA	3	97686291	Silent	SNP	G	TCGA-19-5954-01A-11D-1696-08	64770828	97686291	100336139	18	11876											
ALCAM	214	broad.mit.edu	37	chr3	105238918	105238918	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttttcccccaaaggccttggAtggtatactgtaaattcagc	8	10	1	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr3:105238918A>T	uc003dvx.2	+	2	621	c.81A>T	c.(79-81)GGA>GGT	p.G27G	ALCAM_uc003dvv.2_Silent_p.G27G|ALCAM_uc003dvw.1_Silent_p.G27G|ALCAM_uc003dvy.2_Silent_p.G27G|ALCAM_uc011bhh.1_5'UTR	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	27					cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						AAGGCCTTGGATGGTATACTG	0.294													T	105238918	T	T	105238918	2	4	167	1	0	0	0	0	0	0	0	1	487	320	12	5		5	ALCAM	3	105238918	Silent	SNP	A	TCGA-19-5954-01A-11D-1696-08	7552627	105238918	92783512	19	11877											
BCHE	590	broad.mit.edu	37	chr3	165503999	165503999	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgttgagcacgtagtttcgTcattattcttgttgactctg	9	7	3	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr3:165503999T>C	uc003fem.3	-	3	1778	c.1618A>G	c.(1618-1620)ACG>GCG	p.T540A	BCHE_uc003fen.3_RNA	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	540					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	CGTAGTTTCGTCATTATTCTT	0.363													C	165503999	C	C	165503999	3	2	167	1	0	0	0	0	1	0	0	0	1358	1667	58	4	198	4	BCHE	3	165503999	Missense_Mutation	SNP	T	TCGA-19-5954-01A-11D-1696-08	60265081	165503999	32518431	20	11878											
PIK3CA	5290	broad.mit.edu	37	chr3	178916623	178916623	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaatcagaacaatgcctccaCgaccatcatcaggtgaactg	8	12	3	2	rs1051397		TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr3:178916623C>T	uc003fjk.2	+	2	167	c.10C>T	c.(10-12)CGA>TGA	p.R4*		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	4					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGCCTCCACGACCATCATC	0.393		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			T	178916623	T	T	178916623	4	4	167	1	0	0	0	0	0	1	0	0	11913	528	19	1	12	1	PIK3CA	3	178916623	Nonsense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	13412624	178916623	19105807	21	11879											
PIK3CA	5290	broad.mit.edu	37	chr3	178916945	178916945	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtaggcaaccgtgaagaaaAgatcctcaatcgagaaattg	10	7	1	4			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr3:178916945A>G	uc003fjk.2	+	2	489	c.332A>G	c.(331-333)AAG>AGG	p.K111R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	111					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.K111N(10)|p.K111E(7)|p.K111R(1)|p.K111del(1)|p.K111_I112>N(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CGTGAAGAAAAGATCCTCAAT	0.333		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			G	178916945	G	G	178916945	3	3	167	1	0	0	0	0	1	0	0	0	11913	72	3	4	334	4	PIK3CA	3	178916945	Missense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08	322	178916945	19105485	22	11880											
WDR1	9948	broad.mit.edu	37	chr4	10099515	10099515	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaggaagactgctccaaaCcttgacccaatgacacaggt	9	12	0	4			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr4:10099515C>T	uc003gmf.2	-	5	661	c.378G>A	c.(376-378)AAG>AAA	p.K126K	WDR1_uc003gmg.2_Intron	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	126	WD 2.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CTGCTCCAAACCTTGACCCAA	0.478													T	10099515	T	T	10099515	2	4	167	1	0	0	0	0	0	0	0	1	17269	521	18	3		3	WDR1	4	10099515	Silent	SNP	C	TCGA-19-5954-01A-11D-1696-08		10099515	181054761	23	11881											
CDKL2	8999	broad.mit.edu	37	chr4	76539498	76539498	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaacaaatacttttgaactaCttggtagtctagtccatttg	6	7	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr4:76539498C>G	uc003hiq.2	-	3	829	c.304G>C	c.(304-306)GTA>CTA	p.V102L	CDKL2_uc011cbp.1_Missense_Mutation_p.V102L|CDKL2_uc010iix.1_Intron	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	102	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TTTTGAACTACTTGGTAGTCT	0.294													G	76539498	G	G	76539498	3	3	167	1	0	0	0	0	1	0	0	0	3154	565	20	5	1213	5	CDKL2	4	76539498	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	66439983	76539498	114614778	24	11882											
HTR1A	3350	broad.mit.edu	37	chr5	63256355	63256355	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgaagtatgcgtaaatgaCggggttaagcagagagttgg	16	3	0	3			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr5:63256355C>T	uc011cqt.1	-	1	1192	c.1192G>A	c.(1192-1194)GTC>ATC	p.V398I		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	398	Helical; Name=7; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCGTAAATGACGGGGTTAAGC	0.517													T	63256355	T	T	63256355	3	4	167	1	0	0	0	0	1	0	0	0	7436	536	19	1	79	1	HTR1A	5	63256355	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08		63256355	117658905	25	11883											
GPR98	84059	broad.mit.edu	37	chr5	90049615	90049615	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggtgggctggcgtgctgcGtctgtcttcattagagtagc	15	8	3	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr5:90049615G>A	uc003kju.2	+	54	11442	c.11346G>A	c.(11344-11346)GCG>GCA	p.A3782A	GPR98_uc003kjt.2_Silent_p.A1488A|GPR98_uc003kjv.2_Silent_p.A1382A	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3782	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGCGTGCTGCGTCTGTCTTCA	0.368													A	90049615	A	A	90049615	2	1	167	1	0	0	0	0	0	0	0	1	6721	1132	40	1		1	GPR98	5	90049615	Silent	SNP	G	TCGA-19-5954-01A-11D-1696-08	26793260	90049615	90865645	26	11884											
PCDHA8	56140	broad.mit.edu	37	chr5	140222810	140222810	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcgagatcagcaccactcGtgtcctggacgaagcggact	14	12	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr5:140222810G>A	uc003lhs.2	+	1	1904	c.1904G>A	c.(1903-1905)CGT>CAT	p.R635H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.R635H	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	635	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCACCACTCGTGTCCTGGAC	0.647													A	140222810	A	A	140222810	3	1	167	1	0	0	0	0	1	0	0	0	11530	1145	40	1	1906	1	PCDHA8	5	140222810	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	50173195	140222810	40692450	27	11885											
KIF4B	285643	broad.mit.edu	37	chr5	154395782	154395782	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaagaaaaaaaggaatctcGggagaatccacctcctaaac	7	10	1	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr5:154395782G>A	uc010jih.1	+	1	2523	c.2363G>A	c.(2362-2364)CGG>CAG	p.R788Q		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	788	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAGGAATCTCGGGAGAATCCA	0.438													A	154395782	A	A	154395782	3	1	167	1	0	0	0	0	1	0	0	0	8304	1116	39	2	2365	2	KIF4B	5	154395782	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	14172972	154395782	26519478	28	11886											
ME1	4199	broad.mit.edu	37	chr6	84056027	84056027	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggtctcccaagccaagaatAcgctctccatcagtcaccac	6	16	4	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr6:84056027A>G	uc003pjy.2	-	5	571	c.465T>C	c.(463-465)CGT>CGC	p.R155R	ME1_uc011dzb.1_Silent_p.R80R|ME1_uc011dzc.1_5'UTR	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	155		NADP (By similarity).			carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AGCCAAGAATACGCTCTCCAT	0.428													G	84056027	G	G	84056027	2	3	167	1	0	0	0	0	0	0	0	1	9417	378	14	4		4	ME1	6	84056027	Silent	SNP	A	TCGA-19-5954-01A-11D-1696-08		84056027	87059040	29	11887											
PRDM13	59336	broad.mit.edu	37	chr6	100062503	100062503	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctcgccaaagcgggcgaCggcccgggtgccgagcccgg	17	16	0	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr6:100062503C>T	uc003pqg.1	+	4	2253	c.1992C>T	c.(1990-1992)GAC>GAT	p.D664D		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	664					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		AAGCGGGCGACGGCCCGGGTG	0.687													T	100062503	T	T	100062503	2	4	167	1	0	0	0	0	0	0	0	1	12454	535	19	1		1	PRDM13	6	100062503	Silent	SNP	C	TCGA-19-5954-01A-11D-1696-08	16006476	100062503	71052564	30	11888											
DSE	29940	broad.mit.edu	37	chr6	116720360	116720360	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcctttttatctcacgtaGgatctttcgaagatggtttg	8	7	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr6:116720360G>A	uc003pws.2	+	2	142	c.-52_splice	c.e2-1		DSE_uc011ebf.1_Splice_Site|DSE_uc003pwq.1_Splice_Site|DSE_uc011ebg.1_Splice_Site_p.G2_splice|DSE_uc003pwt.2_Splice_Site	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor						dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		ATCTCACGTAGGATCTTTCGA	0.433													A	116720360	A	A	116720360	5	1	167	1	0	0	0	0	0	0	1	0	4774	1014	35	3		3	DSE	6	116720360	Splice_Site	SNP	G	TCGA-19-5954-01A-11D-1696-08	16657857	116720360	54394707	31	11889											
C6orf170	221322	broad.mit.edu	37	chr6	121427228	121427228	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cacaagaggcaactcagcctTcagtagcatttcaatataat	6	10	3	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr6:121427228T>A	uc003pyo.1	-	30	3474	c.3406A>T	c.(3406-3408)AAG>TAG	p.K1136*		NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	1136	Rab-GAP TBC.				multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		AACTCAGCCTTCAGTAGCATT	0.393													A	121427228	A	A	121427228	4	1	167	1	0	0	0	0	0	1	0	0	2344	1792	62	5	379	5	C6orf170	6	121427228	Nonsense_Mutation	SNP	T	TCGA-19-5954-01A-11D-1696-08	4706868	121427228	49687839	32	11890											
SYNE1	23345	broad.mit.edu	37	chr6	152660497	152660497	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttgcaaagctctgaagtgtTtgacctggaaaaggcagtta	11	7	1	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr6:152660497T>C	uc010kiw.2	-	75	12832	c.12230A>G	c.(12229-12231)AAA>AGA	p.K4077R	SYNE1_uc003qot.3_Missense_Mutation_p.K4006R|SYNE1_uc003qou.3_Missense_Mutation_p.K4077R|SYNE1_uc010kja.1_Missense_Mutation_p.K782R	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4077	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCTGAAGTGTTTGACCTGGAA	0.403										HNSCC(10;0.0054)			C	152660497	C	C	152660497	3	2	167	1	0	0	0	0	1	0	0	0	15442	1841	64	4	14524	4	SYNE1	6	152660497	Missense_Mutation	SNP	T	TCGA-19-5954-01A-11D-1696-08	31233269	152660497	18454570	33	11891											
SNX13	23161	broad.mit.edu	37	chr7	17861198	17861198	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgataggttttccacatctcCtcactgtttaggttgcgccg	9	12	2	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr7:17861198C>T	uc003stw.1	-	18	2025	c.1812G>A	c.(1810-1812)GAG>GAA	p.E604E	SNX13_uc003stv.2_Silent_p.E593E|SNX13_uc010kuc.2_Silent_p.E390E|SNX13_uc010kub.2_5'UTR			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	604	PX.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					TCCACATCTCCTCACTGTTTA	0.413													T	17861198	T	T	17861198	2	4	167	1	0	0	0	0	0	0	0	1	14884	680	24	3		3	SNX13	7	17861198	Silent	SNP	C	TCGA-19-5954-01A-11D-1696-08		17861198	141277465	34	11892											
CHN2	1124	broad.mit.edu	37	chr7	29407583	29407583	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagaggcacctcgtcccaagAgaatcatttgtcctcgggag	11	11	1	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr7:29407583A>G	uc003szz.2	+	3	561	c.124A>G	c.(124-126)AGA>GGA	p.R42G	CHN2_uc011jzs.1_Missense_Mutation_p.R117G|CHN2_uc010kva.2_Intron|CHN2_uc010kvb.2_RNA|CHN2_uc010kvc.2_Intron|CHN2_uc011jzt.1_Missense_Mutation_p.R55G|CHN2_uc010kvd.2_Missense_Mutation_p.R42G|CHN2_uc011jzu.1_Missense_Mutation_p.R27G	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	42					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						TCGTCCCAAGAGAATCATTTG	0.403													G	29407583	G	G	29407583	3	3	167	1	0	0	0	0	1	0	0	0	3363	296	11	4	134	4	CHN2	7	29407583	Missense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08	11546385	29407583	129731080	35	11893											
PLEKHA8	84725	broad.mit.edu	37	chr7	30088881	30088882	+	Frame_Shift_Ins	INS	-	A	A													tgctgaaatcaacctgtaatINSacttttctgaagaccttgga							TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr7:30088881_30088882insA	uc003tam.1	+	5	571_572	c.480_481insA	c.(478-483)AATACTfs	p.N160fs	PLEKHA8_uc003tao.2_Frame_Shift_Ins_p.N44fs|PLEKHA8_uc003tap.1_Frame_Shift_Ins_p.N160fs|PLEKHA8_uc003tan.2_Frame_Shift_Ins_p.N160fs	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A	160_161					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4						CAACCTGTAATACTTTTCTGAA	0.465													A	30088882	A	A	30088881	7	5	167	1	0	1	1	0	0	0	0	0	12062	1403	49	0	498	0	PLEKHA8	7	30088881	Frame_Shift_Ins	INS	-	TCGA-19-5954-01A-11D-1696-08	681298	30088881	129049782	36	11894											
CDK13	8621	broad.mit.edu	37	chr7	40117639	40117639	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccatgtcctgcagtgtggcCtgatgtaatcaaactaccat	8	11	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr7:40117639C>T	uc003thh.3	+	10	3098	c.2816C>T	c.(2815-2817)CCT>CTT	p.P939L	CDK13_uc003thi.3_Missense_Mutation_p.P939L|CDK13_uc003thj.2_5'UTR	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	939	Protein kinase.				alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						GCAGTGTGGCCTGATGTAATC	0.368													T	40117639	T	T	40117639	3	4	167	1	0	0	0	0	1	0	0	0	3129	681	24	3	2854	3	CDK13	7	40117639	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	10028758	40117639	119021024	37	11895											
ABCB1	5243	broad.mit.edu	37	chr7	87148696	87148696	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccaagtaggctccaaacCggaaacatccagcataggaa	8	13	0	0	rs144369247		TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr7:87148696C>T	uc003uiz.1	-	24	3291	c.2873G>A	c.(2872-2874)CGG>CAG	p.R958Q	ABCB1_uc011khc.1_Missense_Mutation_p.R894Q	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	958	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GGCTCCAAACCGGAAACATCC	0.323													T	87148696	T	T	87148696	3	4	167	1	0	0	0	0	1	0	0	0	40	652	23	2	993	2	ABCB1	7	87148696	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	47031057	87148696	71989967	38	11896											
SAMD9L	219285	broad.mit.edu	37	chr7	92761184	92761184	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttttgagttttgctgcagTaggaaggcatattcattcac	9	6	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr7:92761184T>C	uc003umh.1	-	5	5317	c.4101A>G	c.(4099-4101)CTA>CTG	p.L1367L	SAMD9L_uc003umj.1_Silent_p.L1367L|SAMD9L_uc003umi.1_Silent_p.L1367L|SAMD9L_uc010lfb.1_Silent_p.L1367L|SAMD9L_uc003umk.1_Silent_p.L1367L|SAMD9L_uc010lfc.1_Silent_p.L1367L|SAMD9L_uc010lfd.1_Silent_p.L1367L|SAMD9L_uc011khx.1_3'UTR	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1367										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTGCTGCAGTAGGAAGGCAT	0.383													C	92761184	C	C	92761184	2	2	167	1	0	0	0	0	0	0	0	1	13827	1625	57	4		4	SAMD9L	7	92761184	Silent	SNP	T	TCGA-19-5954-01A-11D-1696-08	5612488	92761184	66377479	39	11897											
MUC17	140453	broad.mit.edu	37	chr7	100685627	100685627	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaccattatgcctgtcagcAccacatcggtgaccatttct	6	13	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr7:100685627A>G	uc003uxp.1	+	3	10983	c.10930A>G	c.(10930-10932)ACC>GCC	p.T3644A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3644	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|58.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCCTGTCAGCACCACATCGGT	0.478													G	100685627	G	G	100685627	3	3	167	1	0	0	0	0	1	0	0	0	9974	159	6	4	10940	4	MUC17	7	100685627	Missense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08	7924443	100685627	58453036	40	11898											
PTPRZ1	5803	broad.mit.edu	37	chr7	121651361	121651361	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gacaacccaaccggtatacaAtggtgagacacctcttcaac	7	13	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr7:121651361A>G	uc003vjy.2	+	12	2656	c.2261A>G	c.(2260-2262)AAT>AGT	p.N754S	PTPRZ1_uc003vjz.2_Missense_Mutation_p.N754S|PTPRZ1_uc011knt.1_Missense_Mutation_p.N204S	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	754	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CCGGTATACAATGGTGAGACA	0.488													G	121651361	G	G	121651361	3	3	167	1	0	0	0	0	1	0	0	0	12814	101	4	4	2307	4	PTPRZ1	7	121651361	Missense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08	20965734	121651361	37487302	41	11899											
OR6V1	346517	broad.mit.edu	37	chr7	142749543	142749543	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcatgctttatcttctcGccttcatgggaaacaccatc	5	14	4	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr7:142749543G>A	uc011ksv.1	+	1	106	c.106G>A	c.(106-108)GCC>ACC	p.A36T		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TTATCTTCTCGCCTTCATGGG	0.498													A	142749543	A	A	142749543	3	1	167	1	0	0	0	0	1	0	0	0	11211	1087	38	1	108	1	OR6V1	7	142749543	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	21098182	142749543	16389120	42	11900											
IDO2	169355	broad.mit.edu	37	chr8	39836613	39836613	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgctgagctgccagttcctgAagggtcaccgggagcagcgc	15	12	1	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr8:39836613A>T	uc010lwy.1	+	4	504	c.262A>T	c.(262-264)AAG>TAG	p.K88*	IDO2_uc003xno.1_RNA|IDO2_uc010lwz.1_5'UTR	NM_194294	NP_919270	Q6ZQW0	I23O2_HUMAN	indoleamine-pyrrole 2,3 dioxygenase-like 1	75					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			ovary(2)	2						CCAGTTCCTGAAGGGTCACCG	0.637													T	39836613	T	T	39836613	4	4	167	1	0	0	0	0	0	1	0	0	7502	247	9	5	276	5	IDO2	8	39836613	Nonsense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08		39836613	106527409	43	11901											
FBXO43	286151	broad.mit.edu	37	chr8	101149805	101149805	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tacattacctcagaatctgtTttcagttgtgtgatataaaa	6	6	3	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr8:101149805T>C	uc003yjd.2	-	3	2375	c.1662A>G	c.(1660-1662)AAA>AAG	p.K554K	FBXO43_uc003yje.2_Silent_p.K520K|FBXO43_uc010mbp.1_Silent_p.K554K	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	554					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			CAGAATCTGTTTTCAGTTGTG	0.308													C	101149805	C	C	101149805	2	2	167	1	0	0	0	0	0	0	0	1	5752	1838	64	4		4	FBXO43	8	101149805	Silent	SNP	T	TCGA-19-5954-01A-11D-1696-08	61313192	101149805	45214217	44	11902											
TRPM6	140803	broad.mit.edu	37	chr9	77436668	77436668	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cacaccaccactgggtccttGtccttgacagtctcccacac	6	18	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr9:77436668G>T	uc004ajl.1	-	8	1165	c.927C>A	c.(925-927)GAC>GAA	p.D309E	TRPM6_uc004ajk.1_Missense_Mutation_p.D304E|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.D309E|TRPM6_uc010mpd.1_Missense_Mutation_p.D309E|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	309	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CTGGGTCCTTGTCCTTGACAG	0.592													T	77436668	T	T	77436668	3	4	167	1	0	0	0	0	1	0	0	0	16587	1368	48	5	5269	5	TRPM6	9	77436668	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08		77436668	63776763	45	11903											
MYOF	26509	broad.mit.edu	37	chr10	95148849	95148849	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtactctctggggcttccatAaagattcaggtaacaaggtc	10	9	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr10:95148849A>G	uc001kin.2	-	18	1642	c.1519T>C	c.(1519-1521)TAT>CAT	p.Y507H	MYOF_uc001kio.2_Missense_Mutation_p.Y494H	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	507	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GGGCTTCCATAAAGATTCAGG	0.428													G	95148849	G	G	95148849	3	3	167	1	0	0	0	0	1	0	0	0	10089	362	13	4	4814	4	MYOF	10	95148849	Missense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08		95148849	40385898	46	11904											
MKI67	4288	broad.mit.edu	37	chr10	129906302	129906302	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgatacttctcttgggtcGttgctttgtgcttgttgggg	13	8	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr10:129906302G>A	uc001lke.2	-	13	3997	c.3802C>T	c.(3802-3804)CGA>TGA	p.R1268*	MKI67_uc001lkf.2_Nonsense_Mutation_p.R908*|MKI67_uc009yav.1_Nonsense_Mutation_p.R843*|MKI67_uc009yaw.1_Nonsense_Mutation_p.R418*	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1268	16 X 122 AA approximate repeats.|3.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTCTTGGGTCGTTGCTTTGTG	0.507													A	129906302	A	A	129906302	4	1	167	1	0	0	0	0	0	1	0	0	9598	1153	40	1	5980	1	MKI67	10	129906302	Nonsense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	34757453	129906302	5628445	47	11905											
F2	2147	broad.mit.edu	37	chr11	46750326	46750326	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccctgatgaagctgaagaagCctgttgccttcagtgactac	10	11	1	5			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr11:46750326C>G	uc001ndf.3	+	11	1454	c.1411C>G	c.(1411-1413)CCT>GCT	p.P471A	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	471	Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity	p.P471S(1)		ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	GCTGAAGAAGCCTGTTGCCTT	0.493													G	46750326	G	G	46750326	3	3	167	1	0	0	0	0	1	0	0	0	5342	739	26	5	1453	5	F2	11	46750326	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08		46750326	88256190	48	11906											
FAM111A	63901	broad.mit.edu	37	chr11	58919918	58919918	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acccagccagttgatgaattAgaaggcagatactttcaggt	10	8	1	4			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr11:58919918A>G	uc010rkp.1	+	5	1004	c.777A>G	c.(775-777)TTA>TTG	p.L259L	FAM111A_uc010rkq.1_Silent_p.L259L|FAM111A_uc010rkr.1_Silent_p.L259L|FAM111A_uc001nno.2_Silent_p.L259L|FAM111A_uc001nnp.2_Silent_p.L259L|FAM111A_uc001nnq.2_Silent_p.L259L	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	259					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)				TTGATGAATTAGAAGGCAGAT	0.423													G	58919918	G	G	58919918	2	3	167	1	0	0	0	0	0	0	0	1	5399	417	15	4		4	FAM111A	11	58919918	Silent	SNP	A	TCGA-19-5954-01A-11D-1696-08	12169592	58919918	76086598	49	11907											
NRXN2	9379	broad.mit.edu	37	chr11	64375399	64375399	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggcccccagagggcgggcGgcgcgcggcgggcgggggca	24	14	0	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr11:64375399G>A	uc001oap.2	-	8	1781	c.1270C>T	c.(1270-1272)CGC>TGC	p.R424C	NRXN2_uc001oar.2_Missense_Mutation_p.R1470C|NRXN2_uc001oas.2_Missense_Mutation_p.R1400C|NRXN2_uc001oao.2_Missense_Mutation_p.R110C|NRXN2_uc001oaq.2_Missense_Mutation_p.R1137C	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	424	Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GAgggcgggcggcgcgcggcg	0.612													A	64375399	A	A	64375399	3	1	167	1	0	0	0	0	1	0	0	0	10666	1116	39	2	734	2	NRXN2	11	64375399	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	5455481	64375399	70631117	50	11908											
IL10RA	3587	broad.mit.edu	37	chr11	117860220	117860220	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accctgtcctatgaccttacCgcagtgaccttggacctgta	8	14	0	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr11:117860220C>T	uc001prv.2	+	3	329	c.252C>T	c.(250-252)ACC>ACT	p.T84T	IL10RA_uc010rxl.1_Silent_p.T64T|IL10RA_uc010rxm.1_Silent_p.T64T|IL10RA_uc010rxn.1_Intron|IL10RA_uc001prw.2_5'UTR	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	84	Extracellular (Potential).		T -> I (in IBD28).			integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		ATGACCTTACCGCAGTGACCT	0.577													T	117860220	T	T	117860220	2	4	167	1	0	0	0	0	0	0	0	1	7620	639	23	2		2	IL10RA	11	117860220	Silent	SNP	C	TCGA-19-5954-01A-11D-1696-08	53484821	117860220	17146296	51	11909											
APLP2	334	broad.mit.edu	37	chr11	129999030	129999030	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccacctggcccgagtggaaGctatgctgaatgaccgccgt	12	14	0	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr11:129999030G>A	uc010sby.1	+	10	1541	c.1384G>A	c.(1384-1386)GCT>ACT	p.A462T	APLP2_uc001qfp.2_Missense_Mutation_p.A462T|APLP2_uc001qfq.2_Missense_Mutation_p.A406T|APLP2_uc010sbz.1_Missense_Mutation_p.A250T|APLP2_uc001qfr.2_Missense_Mutation_p.A228T|APLP2_uc001qfs.2_Missense_Mutation_p.A233T|APLP2_uc001qfv.2_Missense_Mutation_p.A353T	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	462	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		CCGAGTGGAAGCTATGCTGAA	0.582													A	129999030	A	A	129999030	3	1	167	1	0	0	0	0	1	0	0	0	779	971	34	3	1422	3	APLP2	11	129999030	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	12138810	129999030	5007486	52	11910											
TAS2R30	259293	broad.mit.edu	37	chr12	11286246	11286246	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagatgtttacacagagaacAgattaacagcagaaaagata	9	5	0	5			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr12:11286246A>G	uc009zhs.1	-	1	598	c.598T>C	c.(598-600)TGT>CGT	p.C200R	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_001097643	NP_001091112			type 2 taste receptor member 30												0						CACAGAGAACAGATTAACAGC	0.428													G	11286246	G	G	11286246	3	3	167	1	0	0	0	0	1	0	0	0	15570	188	7	4	365	4	TAS2R30	12	11286246	Missense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08		11286246	122565649	53	11911											
SOAT2	8435	broad.mit.edu	37	chr12	53516999	53516999	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atactcttccttgtcattggAggtgagctggtctctgtgcc	11	10	3	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr12:53516999A>G	uc001sbv.2	+	13	1459	c.1371A>G	c.(1369-1371)GGA>GGG	p.G457G	SOAT2_uc009zms.2_RNA	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	457	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						TTGTCATTGGAGGTGAGCTGG	0.582													G	53516999	G	G	53516999	2	3	167	1	0	0	0	0	0	0	0	1	14911	318	11	4		4	SOAT2	12	53516999	Silent	SNP	A	TCGA-19-5954-01A-11D-1696-08	42230753	53516999	80334896	54	11912											
CLYBL	171425	broad.mit.edu	37	chr13	100425088	100425088	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tgtcttgcaggaaagcgtctCtagcagctgatatccccaga	10	11	2	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr13:100425088C>G	uc001vok.2	+	2	87	c.73C>G	c.(73-75)CTA>GTA	p.L25V	CLYBL_uc010tix.1_Missense_Mutation_p.L25V|CLYBL_uc010tiy.1_Missense_Mutation_p.L25V	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	25					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GAAAGCGTCTCTAGCAGCTGA	0.388													G	100425088	G	G	100425088	3	3	167	1	0	0	0	0	1	0	0	0	3573	912	32	5	79	5	CLYBL	13	100425088	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08		100425088	14744790	55	11913											
ALDH6A1	4329	broad.mit.edu	37	chr14	74534253	74534253	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tattggcatctggcatgactAccccatggttcttggctccc	9	13	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr14:74534253A>G	uc001xpo.2	-	8	971	c.872T>C	c.(871-873)GTA>GCA	p.V291A	C14orf45_uc001xpm.1_Intron|ALDH6A1_uc010asa.2_Missense_Mutation_p.V136A|ALDH6A1_uc010tuq.1_Missense_Mutation_p.V278A	NM_005589	NP_005580	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6A1 precursor	291						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	TGGCATGACTACCCCATGGTT	0.448													G	74534253	G	G	74534253	3	3	167	1	0	0	0	0	1	0	0	0	503	391	14	4	755	4	ALDH6A1	14	74534253	Missense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08		74534253	32815287	56	11914											
LTBP2	4053	broad.mit.edu	37	chr14	75078642	75078642	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcgggctttggtccgcggCctcatggcgcggggcggctg	19	13	1	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr14:75078642C>T	uc001xqa.2	-	1	393	c.6G>A	c.(4-6)AGG>AGA	p.R2R		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	2					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TGGTCCGCGGCCTCATGGCGC	0.756													T	75078642	T	T	75078642	2	4	167	1	0	0	0	0	0	0	0	1	9074	738	26	3		3	LTBP2	14	75078642	Silent	SNP	C	TCGA-19-5954-01A-11D-1696-08	544389	75078642	32270898	57	11915											
GABRB3	2562	broad.mit.edu	37	chr15	26812728	26812728	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacttaaaaatagcacatacCgagggcaactctagcagcag	8	11	1	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr15:26812728C>T	uc001zaz.2	-	7	977	c.835G>A	c.(835-837)GGG>AGG	p.G279R	GABRB3_uc010uae.1_Missense_Mutation_p.G194R|GABRB3_uc001zba.2_Missense_Mutation_p.G279R|GABRB3_uc001zbb.2_Missense_Mutation_p.G335R	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	279	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TAGCACATACCGAGGGCAACT	0.373													T	26812728	T	T	26812728	3	4	167	1	0	0	0	0	1	0	0	0	6168	666	23	2	598	2	GABRB3	15	26812728	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08		26812728	75718664	58	11916											
ALDH1A2	8854	broad.mit.edu	37	chr15	58306465	58306465	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctctgagttctgccactcGttgtttataaagatctaagg	8	9	3	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr15:58306465G>A	uc002aex.2	-	2	190	c.132C>T	c.(130-132)AAC>AAT	p.N44N	ALDH1A2_uc002aey.2_Silent_p.N44N|ALDH1A2_uc010ugv.1_Silent_p.N23N|ALDH1A2_uc010ugw.1_Silent_p.N15N|ALDH1A2_uc002aew.2_5'Flank	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	44					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TCTGCCACTCGTTGTTTATAA	0.453													A	58306465	A	A	58306465	2	1	167	1	0	0	0	0	0	0	0	1	491	1136	40	1		1	ALDH1A2	15	58306465	Silent	SNP	G	TCGA-19-5954-01A-11D-1696-08	31493737	58306465	44224927	59	11917											
CIB1	10519	broad.mit.edu	37	chr15	90775506	90775506	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcacttgtgcccgaagtgacGactccacgctccgctgctcc	10	17	0	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr15:90775506G>A	uc002bpb.3	-	3	302	c.140C>T	c.(139-141)TCG>TTG	p.S47L	C15orf58_uc002bpc.2_5'Flank	NM_006384	NP_006375	Q99828	CIB1_HUMAN	calcium and integrin binding 1	47					apoptosis|cell adhesion|double-strand break repair	apical plasma membrane|endoplasmic reticulum|filopodium|nucleoplasm	calcium ion binding|protein binding				0	Melanoma(11;0.00551)|Lung NSC(78;0.0141)|all_lung(78;0.0303)		BRCA - Breast invasive adenocarcinoma(143;0.00269)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			CCGAAGTGACGACTCCACGCT	0.612													A	90775506	A	A	90775506	3	1	167	1	0	0	0	0	1	0	0	0	3420	1059	37	2	455	2	CIB1	15	90775506	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	32469041	90775506	11755886	60	11918											
HS3ST6	64711	broad.mit.edu	37	chr16	1962053	1962053	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagagcgtctgggcgtagtcGgagatggcccgggtcacggg	20	9	2	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr16:1962053G>A	uc002cnf.2	-	2	474	c.474C>T	c.(472-474)TCC>TCT	p.S158S		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	158											0						GGGCGTAGTCGGAGATGGCCC	0.721													A	1962053	A	A	1962053	2	1	167	1	0	0	0	0	0	0	0	1	7369	1103	39	2		2	HS3ST6	16	1962053	Silent	SNP	G	TCGA-19-5954-01A-11D-1696-08		1962053	88392700	61	11919											
GDPD3	79153	broad.mit.edu	37	chr16	30124034	30124036	+	In_Frame_Del	DEL	TCA	-	-													ccgactggcggcacaggttcTcatcatgtgacaccaccacc							TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr16:30124034_30124036delTCA	uc002dwp.2	-	3	340_342	c.261_263delTGA	c.(259-264)GATGAG>GAG	p.D87del	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_In_Frame_Del_p.D25del|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	87	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						GCACAGGTTCTCATCATGTGACA	0.645											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	30124036	-	-	30124034	7	5	167	1	0	1	0	1	0	0	0	0	6325	1551	54	0	725	0	GDPD3	16	30124034	In_Frame_Del	DEL	TCA	TCGA-19-5954-01A-11D-1696-08	28161981	30124034	60230719	62	11920											
CHD9	80205	broad.mit.edu	37	chr16	53308187	53308187	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agttattggaaatgagtgtcAgaaagtatttgatggagttg	13	1	1	3			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr16:53308187A>T	uc002ehb.2	+	23	5104	c.4940A>T	c.(4939-4941)CAG>CTG	p.Q1647L	CHD9_uc002egy.2_Missense_Mutation_p.Q1647L|CHD9_uc002ehc.2_Missense_Mutation_p.Q1647L|CHD9_uc002ehf.2_Missense_Mutation_p.Q761L|CHD9_uc010cbw.2_Missense_Mutation_p.Q15L	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1647					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				AATGAGTGTCAGAAAGTATTT	0.244													T	53308187	T	T	53308187	3	4	167	1	0	0	0	0	1	0	0	0	3332	188	7	5	5030	5	CHD9	16	53308187	Missense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08	23184153	53308187	37046566	63	11921											
MFSD6L	162387	broad.mit.edu	37	chr17	8702398	8702398	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtggaagagcttggccaccCccagcgccctgctgatgtcc	13	15	0	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr17:8702398C>A	uc002glp.1	-	1	189	c.41G>T	c.(40-42)GGG>GTG	p.G14V		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	14						integral to membrane				central_nervous_system(1)	1						CTTGGCCACCCCCAGCGCCCT	0.726													A	8702398	A	A	8702398	3	1	167	1	0	0	0	0	1	0	0	0	9536	623	22	5	1723	5	MFSD6L	17	8702398	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08		8702398	72492812	64	11922											
SREBF1	6720	broad.mit.edu	37	chr17	17721038	17721038	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctcaaagactgggctgtcaGgctccgagtcactgccactg	11	14	3	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr17:17721038G>T	uc002gru.1	-	7	1570	c.1376C>A	c.(1375-1377)CCT>CAT	p.P459H	SREBF1_uc002grp.1_Missense_Mutation_p.L29M|SREBF1_uc002grq.1_Translation_Start_Site|SREBF1_uc002grr.1_Missense_Mutation_p.P205H|SREBF1_uc002grs.1_Missense_Mutation_p.P435H|SREBF1_uc002grt.1_Missense_Mutation_p.P489H|SREBF1_uc010cpp.1_Missense_Mutation_p.P435H|SREBF1_uc010cpq.1_Missense_Mutation_p.P459H	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	459	Gly/Pro/Ser-rich.|Cytoplasmic (Potential).|Interaction with LMNA (By similarity).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						TGGGCTGTCAGGCTCCGAGTC	0.607													T	17721038	T	T	17721038	3	4	167	1	0	0	0	0	1	0	0	0	15140	1000	35	5	2119	5	SREBF1	17	17721038	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	9018640	17721038	63474172	65	11923											
RGS9	8787	broad.mit.edu	37	chr17	63221294	63221294	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgcccctcacccatcagaGtggccttggagagctcatcg	10	15	4	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr17:63221294G>A	uc002jfe.2	+	18	1692	c.1582G>A	c.(1582-1584)GTG>ATG	p.V528M	RGS9_uc010dem.2_Missense_Mutation_p.V525M|RGS9_uc002jfd.2_Missense_Mutation_p.V525M|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.V299M	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	528				RVALE -> LVVLD (in Ref. 7; AAC25430).	intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						ACCCATCAGAGTGGCCTTGGA	0.677													A	63221294	A	A	63221294	3	1	167	1	0	0	0	0	1	0	0	0	13313	1029	36	3	1707	3	RGS9	17	63221294	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	45500256	63221294	17973916	66	11924											
SERPINB2	5055	broad.mit.edu	37	chr18	61570323	61570323	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaatttctcagggatgtcGgagaggaatgacctgtttct	12	8	2	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr18:61570323G>A	uc010xeu.1	+	9	1365	c.1032G>A	c.(1030-1032)TCG>TCA	p.S344S	SERPINB2_uc002ljo.2_Silent_p.S344S|SERPINB2_uc010dqh.2_Silent_p.S274S|SERPINB2_uc002ljp.1_Intron|SERPINB2_uc002ljq.1_Intron	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	344					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CAGGGATGTCGGAGAGGAATG	0.498													A	61570323	A	A	61570323	2	1	167	1	0	0	0	0	0	0	0	1	14101	1103	39	2		2	SERPINB2	18	61570323	Silent	SNP	G	TCGA-19-5954-01A-11D-1696-08		61570323	16506925	67	11925											
ADNP2	22850	broad.mit.edu	37	chr18	77895050	77895050	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatcagccagtgagacctgGtgcttcgcagaacaccacct	10	13	1	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr18:77895050G>A	uc002lnw.2	+	4	2209	c.1754G>A	c.(1753-1755)GGT>GAT	p.G585D		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	585					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GTGAGACCTGGTGCTTCGCAG	0.552													A	77895050	A	A	77895050	3	1	167	1	0	0	0	0	1	0	0	0	324	1261	44	3	1764	3	ADNP2	18	77895050	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	16324727	77895050	182198	68	11926											
VAV1	7409	broad.mit.edu	37	chr19	6828672	6828672	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acgaggtcaagcgagacaacGagacactgcgacagatcacc	11	12	2	3			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:6828672G>A	uc002mfu.1	+	12	1229	c.1132G>A	c.(1132-1134)GAG>AAG	p.E378K	VAV1_uc010xjh.1_Missense_Mutation_p.E346K|VAV1_uc010dva.1_Missense_Mutation_p.E378K|VAV1_uc002mfv.1_Missense_Mutation_p.E323K	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	378					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						GCGAGACAACGAGACACTGCG	0.637													A	6828672	A	A	6828672	3	1	167	1	0	0	0	0	1	0	0	0	17128	1059	37	2	1178	2	VAV1	19	6828672	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08		6828672	52300311	69	11927											
MUC16	94025	broad.mit.edu	37	chr19	9014654	9014654	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagggcttttggggtcaagaCggtgggtgcagatggcatcc	17	8	1	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:9014654C>T	uc002mkp.2	-	31	38525	c.38321G>A	c.(38320-38322)CGT>CAT	p.R12774H	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12776	SEA 5.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGGTCAAGACGGTGGGTGCA	0.567													T	9014654	T	T	9014654	3	4	167	1	0	0	0	0	1	0	0	0	9973	536	19	1	5418	1	MUC16	19	9014654	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	2185982	9014654	50114329	70	11928											
IL27RA	9466	broad.mit.edu	37	chr19	14150321	14150321	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgcctctctcctcacagcCgttccaacaaaacccagact	4	20	2	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:14150321C>T	uc002mxx.2	+	3	643	c.220C>T	c.(220-222)CGT>TGT	p.R74C		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	74	Extracellular (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						TCCTCACAGCCGTTCCAACAA	0.547													T	14150321	T	T	14150321	3	4	167	1	0	0	0	0	1	0	0	0	7681	666	23	2	230	2	IL27RA	19	14150321	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	5135667	14150321	44978662	71	11929											
CPAMD8	27151	broad.mit.edu	37	chr19	17017818	17017818	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcaggggctgccgggctgCggagcagggtcagcgcgtag	19	12	2	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:17017818C>T	uc002nfb.2	-	30	4144	c.4112G>A	c.(4111-4113)CGC>CAC	p.R1371H		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1324						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TGCCGGGCTGCGGAGCAGGGT	0.667													T	17017818	T	T	17017818	3	4	167	1	0	0	0	0	1	0	0	0	3795	768	27	1	1738	1	CPAMD8	19	17017818	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	2867497	17017818	42111165	72	11930											
ABHD8	79575	broad.mit.edu	37	chr19	17411828	17411828	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccacctcatagcctaggcGcacaaagaagtccagctgct	8	15	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:17411828G>A	uc002ngb.3	-	2	838	c.598C>T	c.(598-600)CGC>TGC	p.R200C		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	200							hydrolase activity				0						TAGCCTAGGCGCACAAAGAAG	0.642													A	17411828	A	A	17411828	3	1	167	1	0	0	0	0	1	0	0	0	87	1087	38	1	737	1	ABHD8	19	17411828	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	394010	17411828	41717155	73	11931											
LGALS14	56891	broad.mit.edu	37	chr19	40197279	40197279	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttgcctgttggttcgtgcGtgataatcacagggacaccg	12	11	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:40197279G>A	uc002omg.2	+	2	281	c.58G>A	c.(58-60)GTG>ATG	p.V20M	LGALS14_uc002omf.2_Missense_Mutation_p.V49M	NM_020129	NP_064514	Q8TCE9	PPL13_HUMAN	lectin, galactoside-binding, soluble, 14 isoform	20	Galectin.					nucleus	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;4.39e-06)|all_lung(34;6.76e-08)|Lung NSC(34;7.98e-08)|Ovarian(47;0.06)	Myeloproliferative disorder(2;0.0741)	Epithelial(26;1.08e-24)|OV - Ovarian serous cystadenocarcinoma(5;1.92e-24)|all cancers(26;4.12e-22)			TGGTTCGTGCGTGATAATCAC	0.498													A	40197279	A	A	40197279	3	1	167	1	0	0	0	0	1	0	0	0	8741	1145	40	1	170	1	LGALS14	19	40197279	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	22785451	40197279	18931704	74	11932											
KLK5	25818	broad.mit.edu	37	chr19	51452018	51452018	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attcaagcactggaggacctTagggaagtgcactgtcaaac	11	9	2	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:51452018T>C	uc002pue.2	-	6	822	c.604A>G	c.(604-606)AAG>GAG	p.K202E	KLK5_uc002puf.2_Missense_Mutation_p.K202E|KLK5_uc002pug.2_Missense_Mutation_p.K202E	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	202	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		TGGAGGACCTTAGGGAAGTGC	0.502													C	51452018	C	C	51452018	3	2	167	1	0	0	0	0	1	0	0	0	8407	1763	61	4	285	4	KLK5	19	51452018	Missense_Mutation	SNP	T	TCGA-19-5954-01A-11D-1696-08	11254739	51452018	7676965	75	11933											
KIR3DL1	3811	broad.mit.edu	37	chr19	55331314	55331314	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaaggacccctcacgcctcGttggacagatccatgatggg	11	13	1	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:55331314G>A	uc002qhk.3	+	4	565	c.502G>A	c.(502-504)GTT>ATT	p.V168I	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.V110I|KIR3DL1_uc010esf.2_Missense_Mutation_p.V73I|KIR3DL1_uc010yfo.1_Missense_Mutation_p.V110I|KIR3DL1_uc002qhl.3_Missense_Mutation_p.V168I	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	168	Extracellular (Potential).|Ig-like C2-type 2.				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CTCACGCCTCGTTGGACAGAT	0.502													A	55331314	A	A	55331314	3	1	167	1	0	0	0	0	1	0	0	0	8320	1145	40	1	516	1	KIR3DL1	19	55331314	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	3879296	55331314	3797669	76	11934											
SYT5	6861	broad.mit.edu	37	chr19	55685985	55685985	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcttccgcacctttttgCcgccctgcagcaggtggacc	9	16	2	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:55685985C>T	uc002qjm.1	-	7	1920	c.860G>A	c.(859-861)GGC>GAC	p.G287D	SYT5_uc002qjp.2_Missense_Mutation_p.G283D|SYT5_uc002qjn.1_Missense_Mutation_p.G287D|SYT5_uc002qjo.1_Missense_Mutation_p.G286D	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	287	Cytoplasmic (Potential).|C2 2.				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CACCTTTTTGCCGCCCTGCAG	0.517													T	55685985	T	T	55685985	3	4	167	1	0	0	0	0	1	0	0	0	15474	739	26	3	308	3	SYT5	19	55685985	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	354671	55685985	3442998	77	11935											
ZSCAN1	284312	broad.mit.edu	37	chr19	58565136	58565136	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgagcaccagaagacccatcGcgaggaagggccctttccgt	12	14	0	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr19:58565136G>A	uc002qrc.1	+	6	1191	c.944G>A	c.(943-945)CGC>CAC	p.R315H		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	315					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AAGACCCATCGCGAGGAAGGG	0.647													A	58565136	A	A	58565136	3	1	167	1	0	0	0	0	1	0	0	0	18223	1087	38	1	958	1	ZSCAN1	19	58565136	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	2879151	58565136	563847	78	11936											
EMILIN3	90187	broad.mit.edu	37	chr20	39990117	39990119	+	In_Frame_Del	DEL	CCT	-	-													gcccagcctcctgcacgcacCctccacttgtgccacccgct							TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr20:39990117_39990119delCCT	uc002xjy.1	-	4	2314_2316	c.2090_2092delAGG	c.(2089-2094)GAGGGT>GGT	p.E697del		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	697						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				CTGCACGCACCCTCCACTTGTGC	0.665													-	39990119	-	-	39990117	7	5	167	1	0	1	0	1	0	0	0	0	5095	623	22	0	212	0	EMILIN3	20	39990117	In_Frame_Del	DEL	CCT	TCGA-19-5954-01A-11D-1696-08		39990117	23035403	79	11937											
ERG	2078	broad.mit.edu	37	chr21	39795376	39795376	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgttcgtggtcatgtttgggGgtggcatgtgcttctcctcc	14	10	2	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr21:39795376G>A	uc010gnw.2	-	5	660	c.365C>T	c.(364-366)CCC>CTC	p.P122L	ERG_uc002yxa.2_Missense_Mutation_p.P115L|ERG_uc011aek.1_Missense_Mutation_p.P23L|ERG_uc010gnv.2_Missense_Mutation_p.P23L|ERG_uc010gnx.2_Missense_Mutation_p.P122L|ERG_uc011ael.1_Missense_Mutation_p.P122L|ERG_uc002yxb.2_Missense_Mutation_p.P122L|ERG_uc011aem.1_Missense_Mutation_p.P115L|ERG_uc002yxc.3_Missense_Mutation_p.P122L	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	122	PNT.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CATGTTTGGGGGTGGCATGTG	0.592													A	39795376	A	A	39795376	3	1	167	1	0	0	0	0	1	0	0	0	5222	1232	43	3	1127	3	ERG	21	39795376	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08		39795376	8334519	80	11938											
POFUT2	23275	broad.mit.edu	37	chr21	46689872	46689872	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tcctgtctgtgaccccagatGaaatcttttcttctcaggtg	8	11	4	3			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chr21:46689872G>A	uc002zhc.2	-	7	919	c.894C>T	c.(892-894)TTC>TTT	p.F298F	POFUT2_uc002zha.2_RNA|POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_Silent_p.F298F	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	298					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		GACCCCAGATGAAATCTTTTC	0.572													A	46689872	A	A	46689872	2	1	167	1	0	0	0	0	0	0	0	1	12184	1281	45	3		3	POFUT2	21	46689872	Silent	SNP	G	TCGA-19-5954-01A-11D-1696-08	6894496	46689872	1440023	81	11939											
MXRA5	25878	broad.mit.edu	37	chrX	3242355	3242355	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatattgtttgagaatactgGgtgtagtaggaaagtagcac	13	3	0	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:3242355G>T	uc004crg.3	-	5	1528	c.1371C>A	c.(1369-1371)ACC>ACA	p.T457T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	457						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GAGAATACTGGGTGTAGTAGG	0.488													T	3242355	T	T	3242355	2	4	167	1	0	0	0	0	0	0	0	1	10003	1219	43	5		5	MXRA5	23	3242355	Silent	SNP	G	TCGA-19-5954-01A-11D-1696-08		3242355	152028205	82	11940											
DCAF8L1	139425	broad.mit.edu	37	chrX	27999353	27999353	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaatgtctgaggaggccgcCgtcaccgctgctactccaga	11	14	3	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:27999353C>T	uc004dbx.1	-	1	214	c.99G>A	c.(97-99)ACG>ACA	p.T33T		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	33										ovary(3)|skin(1)	4						AGGAGGCCGCCGTCACCGCTG	0.567													T	27999353	T	T	27999353	2	4	167	1	0	0	0	0	0	0	0	1	4277	639	23	2		2	DCAF8L1	23	27999353	Silent	SNP	C	TCGA-19-5954-01A-11D-1696-08	24756998	27999353	127271207	83	11941											
GPR34	2857	broad.mit.edu	37	chrX	41555890	41555890	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgatgtccagtaacattcGcaaaataatgtgccaacttc	6	11	0	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:41555890G>A	uc004dfp.3	+	3	1288	c.1004G>A	c.(1003-1005)CGC>CAC	p.R335H	CASK_uc004dfl.3_Intron|CASK_uc004dfm.3_Intron|CASK_uc004dfn.3_Intron|GPR34_uc004dfq.3_Missense_Mutation_p.R335H|GPR34_uc010nhg.2_Missense_Mutation_p.R335H|GPR34_uc004dfr.3_Missense_Mutation_p.R335H	NM_001097579	NP_001091048	Q9UPC5	GPR34_HUMAN	G protein-coupled receptor 34	335	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						AGTAACATTCGCAAAATAATG	0.373													A	41555890	A	A	41555890	3	1	167	1	0	0	0	0	1	0	0	0	6689	1087	38	1	1006	1	GPR34	23	41555890	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	13556537	41555890	113714670	84	11942											
DGAT2L6	347516	broad.mit.edu	37	chrX	69420246	69420246	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttttcccatccatcactcccTttgtagggaccttagaaagg	7	12	1	1			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:69420246T>A	uc004dxx.1	+	4	506	c.409T>A	c.(409-411)TTT>ATT	p.F137I		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	137					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						CATCACTCCCTTTGTAGGGAC	0.413													A	69420246	A	A	69420246	3	1	167	1	0	0	0	0	1	0	0	0	4459	1609	56	5	423	5	DGAT2L6	23	69420246	Missense_Mutation	SNP	T	TCGA-19-5954-01A-11D-1696-08	27864356	69420246	85850314	85	11943											
CENPI	2491	broad.mit.edu	37	chrX	100382542	100382542	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttccagtagctacactaaagAatgtggaaaaaaagagatga	9	5	0	3			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:100382542A>G	uc004egx.2	+	10	1232	c.962A>G	c.(961-963)GAA>GGA	p.E321G	CENPI_uc011mrg.1_Missense_Mutation_p.E321G|CENPI_uc004egy.2_Missense_Mutation_p.E321G	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	321					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						TACACTAAAGAATGTGGAAAA	0.353													G	100382542	G	G	100382542	3	3	167	1	0	0	0	0	1	0	0	0	3233	246	9	4	996	4	CENPI	23	100382542	Missense_Mutation	SNP	A	TCGA-19-5954-01A-11D-1696-08	30962296	100382542	54888018	86	11944											
ARMCX5	64860	broad.mit.edu	37	chrX	101858012	101858012	+	Frame_Shift_Del	DEL	C	-	-													agcctaaagagtttgataaaCttgttgccctccttaagtta							TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:101858012delC	uc004ejg.2	+	6	1824	c.943delC	c.(943-945)CTTfs	p.L315fs	ARMCX5_uc004ejh.2_Frame_Shift_Del_p.L315fs	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	315	ARM 1.						binding			ovary(1)	1						GTTTGATAAACTTGTTGCCCT	0.388													-	101858012	-	-	101858012	7	5	167	1	0	1	0	1	0	0	0	0	962	565	20	0	945	0	ARMCX5	23	101858012	Frame_Shift_Del	DEL	C	TCGA-19-5954-01A-11D-1696-08	1475470	101858012	53412548	87	11945			1	32		2	2	18	N	G_C	4.997173e-05
ARMCX5	64860	broad.mit.edu	37	chrX	101858029	101858029	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaacttgttgccctccttaaGttaactaaggatcctttcat	5	10	1	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:101858029G>C	uc004ejg.2	+	6	1841	c.960G>C	c.(958-960)AAG>AAC	p.K320N	ARMCX5_uc004ejh.2_Missense_Mutation_p.K320N	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	320	ARM 1.						binding			ovary(1)	1						CCCTCCTTAAGTTAACTAAGG	0.383													C	101858029	C	C	101858029	3	2	167	1	0	0	0	0	1	0	0	0	962	1020	36	5	962	5	ARMCX5	23	101858029	Missense_Mutation	SNP	G	TCGA-19-5954-01A-11D-1696-08	17	101858029	53412531	88	11946			1	32		2	2	18	N	G_C	4.997173e-05
SLITRK4	139065	broad.mit.edu	37	chrX	142717642	142717642	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccattgagatatagcctgCgtaaattagtgagattgtga	11	5	0	3			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:142717642C>T	uc004fbx.2	-	2	1659	c.1283G>A	c.(1282-1284)CGC>CAC	p.R428H	SLITRK4_uc004fby.2_Missense_Mutation_p.R428H	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	428	Extracellular (Potential).|LRR 9.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ATATAGCCTGCGTAAATTAGT	0.358													T	142717642	T	T	142717642	3	4	167	1	0	0	0	0	1	0	0	0	14745	768	27	1	1234	1	SLITRK4	23	142717642	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	40859613	142717642	12552918	89	11947											
PASD1	139135	broad.mit.edu	37	chrX	150828252	150828252	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cgttcacatgtttgtagattCtgattcaacttattgctcca	6	9	3	2			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:150828252C>A	uc004fev.3	+	10	1117	c.785C>A	c.(784-786)TCT>TAT	p.S262Y		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	262						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGTAGATTCTGATTCAACT	0.373													A	150828252	A	A	150828252	3	1	167	1	0	0	0	0	1	0	0	0	11471	913	32	5	819	5	PASD1	23	150828252	Missense_Mutation	SNP	C	TCGA-19-5954-01A-11D-1696-08	8110610	150828252	4442308	90	11948											
DUSP9	1852	broad.mit.edu	37	chrX	152915703	152915703	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatctgcggcctccaacccGccctccttcttcaccacccc	5	23	3	0			TCGA-19-5954-01A-11D-1696-08	TCGA-19-5954-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	cfd4e06e-203f-4a6f-8aa9-60828e0d4d68	868686a8-f6d2-4ed3-b1a7-49bf9da29e22	g.chrX:152915703G>A	uc004fhx.3	+	4	1302	c.1098G>A	c.(1096-1098)CCG>CCA	p.P366P	DUSP9_uc004fhy.3_Silent_p.P366P	NM_001395	NP_001386	Q99956	DUS9_HUMAN	dual specificity phosphatase 9	366	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCAACCCGCCCTCCTTCT	0.716													A	152915703	A	A	152915703	2	1	167	1	0	0	0	0	0	0	0	1	4832	1074	38	1		1	DUSP9	23	152915703	Silent	SNP	G	TCGA-19-5954-01A-11D-1696-08	2087451	152915703	2354857	91	11949											
CLCN6	1185	broad.mit.edu	37	chr1	11897139	11897139	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccatccagcgagctacggaaCatgtgtgatgagcacatcgc	11	12	0	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:11897139C>T	uc001ate.3	+	19	2177	c.2064C>T	c.(2062-2064)AAC>AAT	p.N688N	CLCN6_uc010oat.1_Silent_p.N404N|CLCN6_uc010oau.1_Silent_p.N666N	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	688	Cytoplasmic (By similarity).				cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		AGCTACGGAACATGTGTGATG	0.632													T	11897139	T	T	11897139	2	4	168	1	0	0	0	0	0	0	0	1	3467	477	17	3		3	CLCN6	1	11897139	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08		11897139	237353482	1	11950											
PADI3	51702	broad.mit.edu	37	chr1	17609431	17609431	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcctggaggagaaggtgCggtccctgctggagccgctg	18	11	0	1	rs144763474	byFrequency	TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:17609431C>T	uc001bai.2	+	16	1892	c.1852C>T	c.(1852-1854)CGG>TGG	p.R618W		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	618					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GGAGAAGGTGCGGTCCCTGCT	0.602													T	17609431	T	T	17609431	3	4	168	1	0	0	0	0	1	0	0	0	11379	759	27	1	1914	1	PADI3	1	17609431	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	5712292	17609431	231641190	2	11951											
CNR2	1269	broad.mit.edu	37	chr1	24202118	24202118	+	Translation_Start_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attcctccatggggtgggccCttcagattccactgagcttg	11	12	1	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:24202118C>A	uc001bif.2	-	2	117	c.-10G>T	c.(-12--8)AAGGG>AATGG			NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)						behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	GGGGTGGGCCCTTCAGATTCC	0.458													A	24202118	A	A	24202118	1	1	168	1	0	0	0	0	0	0	0	0	3632	696	24	5		5	CNR2	1	24202118	Translation_Start_Site	SNP	C	TCGA-19-5955-01A-11D-1696-08	6592687	24202118	225048503	3	11952											
TMEM57	55219	broad.mit.edu	37	chr1	25784890	25784890	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggtattgtagcagccaaaGgattacctgatatggattct	10	6	1	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:25784890G>A	uc001bkk.2	+	6	863	c.661G>A	c.(661-663)GGA>AGA	p.G221R	TMEM57_uc009vru.2_Intron|TMEM57_uc009vrv.2_Intron|TMEM57_uc009vrt.2_RNA	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	221						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		AGCAGCCAAAGGATTACCTGA	0.378													A	25784890	A	A	25784890	3	1	168	1	0	0	0	0	1	0	0	0	16181	1001	35	3	683	3	TMEM57	1	25784890	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	1582772	25784890	223465731	4	11953											
SFRS11	9295	broad.mit.edu	37	chr1	70716405	70716405	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aaacaaaggaatgttctgtgGaaaagggaactggtgattca	12	4	2	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:70716405G>T	uc001des.2	+	13	1496	c.1372G>T	c.(1372-1374)GAA>TAA	p.E458*	SFRS11_uc001det.2_Nonsense_Mutation_p.E457*|SFRS11_uc001dev.2_Nonsense_Mutation_p.E268*|SFRS11_uc001dew.2_Nonsense_Mutation_p.E398*	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	458					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						ATGTTCTGTGGAAAAGGGAAC	0.398													T	70716405	T	T	70716405	4	4	168	1	0	0	0	0	0	1	0	0	14166	1175	41	5	1418	5	SFRS11	1	70716405	Nonsense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	44931515	70716405	178534216	5	11954											
C1orf173	127254	broad.mit.edu	37	chr1	75037396	75037396	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagccacaacccttcctcctCccatgccctcattcttttgt	3	19	2	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:75037396C>T	uc001dgg.2	-	14	4217	c.3998G>A	c.(3997-3999)GGA>GAA	p.G1333E		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1333	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTTCCTCCTCCCATGCCCTC	0.562													T	75037396	T	T	75037396	3	4	168	1	0	0	0	0	1	0	0	0	2014	855	30	3	598	3	C1orf173	1	75037396	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	4320991	75037396	174213225	6	11955											
FNDC7	163479	broad.mit.edu	37	chr1	109270578	109270578	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaatgacactactcctgcGtgcaccctttcggctctaga	8	14	1	2	rs151239518	by1000genomes	TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:109270578G>A	uc001dvx.2	+	7	1260	c.1260G>A	c.(1258-1260)GCG>GCA	p.A420A	FNDC7_uc010ova.1_Silent_p.A187A	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	421	Fibronectin type-III 5.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		CTACTCCTGCGTGCACCCTTT	0.483													A	109270578	A	A	109270578	2	1	168	1	0	0	0	0	0	0	0	1	5973	1132	40	1		1	FNDC7	1	109270578	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	34233182	109270578	139980043	7	11956											
FLG	2312	broad.mit.edu	37	chr1	152276186	152276186	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagtactgggcccagcccGtccatgggcagactcagact	11	15	1	2	rs145171931	byFrequency	TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:152276186G>A	uc001ezu.1	-	3	11212	c.11176C>T	c.(11176-11178)CGG>TGG	p.R3726W		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3726	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCCAGCCCGTCCATGGGCA	0.607									Ichthyosis				A	152276186	A	A	152276186	3	1	168	1	0	0	0	0	1	0	0	0	5922	1144	40	1	1013	1	FLG	1	152276186	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	43005608	152276186	96974435	8	11957											
NUF2	83540	broad.mit.edu	37	chr1	163306614	163306614	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagaagcatgccgtgaaacGtatatggaatttctttggca	11	6	1	2	rs148215962		TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:163306614G>A	uc001gcq.1	+	6	711	c.411G>A	c.(409-411)ACG>ACA	p.T137T	NUF2_uc001gcp.2_Silent_p.T137T|NUF2_uc001gcr.1_Silent_p.T137T|NUF2_uc009wvc.1_Silent_p.T137T	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	137	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					GCCGTGAAACGTATATGGAAT	0.313													A	163306614	A	A	163306614	2	1	168	1	0	0	0	0	0	0	0	1	10747	1132	40	1		1	NUF2	1	163306614	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	11030428	163306614	85944007	9	11958											
PAPPA2	60676	broad.mit.edu	37	chr1	176734853	176734853	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agctgtccgtcattgctgctTgatcatgctgatgtggtgaa	12	8	2	3			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:176734853T>C	uc001gkz.2	+	15	5367	c.4203T>C	c.(4201-4203)CTT>CTC	p.L1401L	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1401	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CATTGCTGCTTGATCATGCTG	0.507													C	176734853	C	C	176734853	2	2	168	1	0	0	0	0	0	0	0	1	11433	1799	63	4		4	PAPPA2	1	176734853	Silent	SNP	T	TCGA-19-5955-01A-11D-1696-08	13428239	176734853	72515768	10	11959											
SLC45A3	85414	broad.mit.edu	37	chr1	205632180	205632180	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggttccggaaagccaagcGggcccggcatggacagcagt	15	12	0	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:205632180G>A	uc001hda.1	-	3	1078	c.739C>T	c.(739-741)CGC>TGC	p.R247C	SLC45A3_uc010prn.1_5'Flank|SLC45A3_uc010pro.1_Missense_Mutation_p.R81C|SLC45A3_uc010prp.1_Intron|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	247					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			AAAGCCAAGCGGGCCCGGCAT	0.716			T	ETV1|ETV5|ELK4|ERG	prostate 								A	205632180	A	A	205632180	3	1	168	1	0	0	0	0	1	0	0	0	14642	1116	39	2	934	2	SLC45A3	1	205632180	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	28897327	205632180	43618441	11	11960											
LEFTY2	7044	broad.mit.edu	37	chr1	226125177	226125177	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttggcacgagcgccccatcCgaggcacagctgcacttctg	11	16	1	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:226125177C>T	uc001hpt.1	-	4	1145	c.1065G>A	c.(1063-1065)TCG>TCA	p.S355S	LEFTY2_uc010pvk.1_Silent_p.S321S|LEFTY2_uc009xek.1_3'UTR	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor	355					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					GCGCCCCATCCGAGGCACAGC	0.602													T	226125177	T	T	226125177	2	4	168	1	0	0	0	0	0	0	0	1	8716	639	23	2		2	LEFTY2	1	226125177	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08	20492997	226125177	23125444	12	11961											
OR2M2	391194	broad.mit.edu	37	chr1	248343988	248343988	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgggatctggagagggtcGttgcaaagctttcacgacct	13	9	2	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:248343988G>A	uc010pzf.1	+	1	701	c.701G>A	c.(700-702)CGT>CAT	p.R234H		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGAGAGGGTCGTTGCAAAGCT	0.468													A	248343988	A	A	248343988	3	1	168	1	0	0	0	0	1	0	0	0	11010	1145	40	1	703	1	OR2M2	1	248343988	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	22218811	248343988	906633	13	11962											
OR2T27	403239	broad.mit.edu	37	chr1	248813409	248813409	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtaagaatgaggcagcacGtatgtgtacatggcagcccc	13	9	0	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr1:248813409G>A	uc010pzo.1	-	1	777	c.777C>T	c.(775-777)TAC>TAT	p.Y259Y		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAGGCAGCACGTATGTGTACA	0.532													A	248813409	A	A	248813409	2	1	168	1	0	0	0	0	0	0	0	1	11021	1140	40	1		1	OR2T27	1	248813409	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	469421	248813409	437212	14	11963											
DCTN1	1639	broad.mit.edu	37	chr2	74598790	74598790	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctcagctcacctgctgaCgctgagccagaggggcccag	13	15	2	3			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr2:74598790C>T	uc002skx.2	-	8	830	c.519G>A	c.(517-519)GCG>GCA	p.A173A	DCTN1_uc002skv.2_Silent_p.A39A|DCTN1_uc002sku.2_Silent_p.A39A|DCTN1_uc002skw.1_Silent_p.A149A|DCTN1_uc010ffd.2_Silent_p.A153A|DCTN1_uc002sky.2_Silent_p.A136A	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	173	Ser-rich.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						CACCTGCTGACGCTGAGCCAG	0.652													T	74598790	T	T	74598790	2	4	168	1	0	0	0	0	0	0	0	1	4306	523	19	1		1	DCTN1	2	74598790	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08		74598790	168600583	15	11964											
IL1RL2	8808	broad.mit.edu	37	chr2	102849423	102849423	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cttgtccaattccttttcagAtgggaagctgtatgacgcct	9	10	1	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr2:102849423A>T	uc002tbs.2	+	10	1262	c.1136A>T	c.(1135-1137)GAT>GTT	p.D379V	IL1RL2_uc002tbt.2_Missense_Mutation_p.D261V	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	379	Cytoplasmic (Potential).				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						TCCTTTTCAGATGGGAAGCTG	0.507													T	102849423	T	T	102849423	3	4	168	1	0	0	0	0	1	0	0	0	7664	347	12	5	1170	5	IL1RL2	2	102849423	Missense_Mutation	SNP	A	TCGA-19-5955-01A-11D-1696-08	28250633	102849423	140349950	16	11965											
TTN	7273	broad.mit.edu	37	chr2	179446667	179446667	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcataagcggccttggatgcGtcactgggtttgcctggtcc	14	11	1	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr2:179446667G>A	uc010zfg.1	-	264	58949	c.58725C>T	c.(58723-58725)GAC>GAT	p.D19575D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.D13270D|TTN_uc010zfi.1_Silent_p.D13203D|TTN_uc010zfj.1_Silent_p.D13078D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20502							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGGATGCGTCACTGGGTT	0.438													A	179446667	A	A	179446667	2	1	168	1	0	0	0	0	0	0	0	1	16732	1136	40	1		1	TTN	2	179446667	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	76597244	179446667	63752706	17	11966											
TTN	7273	broad.mit.edu	37	chr2	179666963	179666963	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttagtcacggcggggatcGtcagtttagcgcggccatcg	14	11	2	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr2:179666963G>A	uc002und.2	-	3	422	c.197C>T	c.(196-198)ACG>ATG	p.T66M	TTN_uc010zfg.1_Missense_Mutation_p.T66M|TTN_uc010zfh.1_Missense_Mutation_p.T66M|TTN_uc010zfi.1_Missense_Mutation_p.T66M|TTN_uc010zfj.1_Missense_Mutation_p.T66M|TTN_uc002unb.2_Missense_Mutation_p.T66M			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	66							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCGGGGATCGTCAGTTTAGC	0.547													A	179666963	A	A	179666963	3	1	168	1	0	0	0	0	1	0	0	0	16732	1145	40	1	111231	1	TTN	2	179666963	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	220296	179666963	63532410	18	11967											
DCLK3	85443	broad.mit.edu	37	chr3	36779980	36779980	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagctcttgggggtctcGgtctccccacagcggtggtc	14	14	3	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr3:36779980G>A	uc003cgi.2	-	2	662	c.171C>T	c.(169-171)ACC>ACT	p.T57T		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	57						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						TGGGGGTCTCGGTCTCCCCAC	0.617													A	36779980	A	A	36779980	2	1	168	1	0	0	0	0	0	0	0	1	4293	1103	39	2		2	DCLK3	3	36779980	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08		36779980	161242450	19	11968											
GOLGA4	2803	broad.mit.edu	37	chr3	37360647	37360647	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaccaagaagcttcagaccCgagaaagggaatttcaggaa	11	8	2	4			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr3:37360647C>T	uc003cgv.2	+	12	1811	c.1507C>T	c.(1507-1509)CGA>TGA	p.R503*	GOLGA4_uc010hgr.1_Intron|GOLGA4_uc003cgw.2_Nonsense_Mutation_p.R525*|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Nonsense_Mutation_p.R384*	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	503	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GCTTCAGACCCGAGAAAGGGA	0.378													T	37360647	T	T	37360647	4	4	168	1	0	0	0	0	0	1	0	0	6555	644	23	2	1623	2	GOLGA4	3	37360647	Nonsense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	580667	37360647	160661783	20	11969											
VIPR1	7433	broad.mit.edu	37	chr3	42567437	42567437	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgcacctggagcctggcccGtaccccattgcctgtggttt	11	15	0	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr3:42567437G>A	uc003clf.2	+	4	475	c.351G>A	c.(349-351)CCG>CCA	p.P117P	VIPR1_uc011azl.1_Silent_p.P70P|VIPR1_uc011azm.1_5'UTR|VIPR1_uc011azn.1_Silent_p.P90P	NM_004624	NP_004615	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	117	Extracellular (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.241)		AGCCTGGCCCGTACCCCATTG	0.662													A	42567437	A	A	42567437	2	1	168	1	0	0	0	0	0	0	0	1	17166	1132	40	1		1	VIPR1	3	42567437	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	5206790	42567437	155454993	21	11970											
GRM2	2912	broad.mit.edu	37	chr3	51746533	51746533	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatcccacagattagctaCgcctctaccagtgccaagct	7	15	1	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr3:51746533C>T	uc010hlv.2	+	3	734	c.495C>T	c.(493-495)TAC>TAT	p.Y165Y	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	165	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	AGATTAGCTACGCCTCTACCA	0.532													T	51746533	T	T	51746533	2	4	168	1	0	0	0	0	0	0	0	1	6797	547	19	1		1	GRM2	3	51746533	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08	9179096	51746533	146275897	22	11971											
TRAT1	50852	broad.mit.edu	37	chr3	108572525	108572525	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacagcgttaaggggaagcGtagaaagcccaggaaacaga	13	8	1	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr3:108572525G>A	uc003dxi.1	+	6	506	c.362G>A	c.(361-363)CGT>CAT	p.R121H	TRAT1_uc010hpx.1_Missense_Mutation_p.R84H	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	121	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						AAGGGGAAGCGTAGAAAGCCC	0.423													A	108572525	A	A	108572525	3	1	168	1	0	0	0	0	1	0	0	0	16463	1145	40	1	384	1	TRAT1	3	108572525	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	56825992	108572525	89449905	23	11972											
GPR156	165829	broad.mit.edu	37	chr3	119962857	119962857	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgctcacttacaattgttGtcttgcagagatcatgaagg	10	8	3	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr3:119962857G>A	uc011bjf.1	-	1	89	c.89C>T	c.(88-90)ACA>ATA	p.T30I	GPR156_uc011bjg.1_Missense_Mutation_p.T30I	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	30	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		TACAATTGTTGTCTTGCAGAG	0.433													A	119962857	A	A	119962857	3	1	168	1	0	0	0	0	1	0	0	0	6661	1377	48	3	2391	3	GPR156	3	119962857	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	11390332	119962857	78059573	24	11973											
DBR1	51163	broad.mit.edu	37	chr3	137890532	137890532	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaccgatccttacacctcGgtattttaccacaccagcca	4	17	0	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr3:137890532G>A	uc003erv.2	-	3	482	c.346C>T	c.(346-348)CGA>TGA	p.R116*	DBR1_uc003eru.2_Nonsense_Mutation_p.R65*	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	116						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						CTTACACCTCGGTATTTTACC	0.343													A	137890532	A	A	137890532	4	1	168	1	0	0	0	0	0	1	0	0	4257	1124	39	2	1312	2	DBR1	3	137890532	Nonsense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	17927675	137890532	60131898	25	11974											
CLSTN2	64084	broad.mit.edu	37	chr3	140185512	140185512	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcctcgtctttctcttgcGgaaggacttcgaccaggctg	11	14	2	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr3:140185512G>A	uc003etn.2	+	8	1473	c.1283G>A	c.(1282-1284)CGG>CAG	p.R428Q	CLSTN2_uc003etm.2_Missense_Mutation_p.R428Q	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	428	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TTTCTCTTGCGGAAGGACTTC	0.542										HNSCC(16;0.037)			A	140185512	A	A	140185512	3	1	168	1	0	0	0	0	1	0	0	0	3562	1116	39	2	1313	2	CLSTN2	3	140185512	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	2294980	140185512	57836918	26	11975											
ZBBX	79740	broad.mit.edu	37	chr3	167083682	167083682	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtatcttcttaccttaacaaCatttcctttattttgtgaca	3	9	2	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr3:167083682C>A	uc003fep.2	-	6	588	c.265G>T	c.(265-267)GTT>TTT	p.V89F	ZBBX_uc011bpc.1_Missense_Mutation_p.V89F|ZBBX_uc003feq.2_Missense_Mutation_p.V60F	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	89						intracellular	zinc ion binding			ovary(2)	2						ACCTTAACAACATTTCCTTTA	0.294													A	167083682	A	A	167083682	3	1	168	1	0	0	0	0	1	0	0	0	17513	478	17	5	2201	5	ZBBX	3	167083682	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	26898170	167083682	30938748	27	11976											
FRYL	285527	broad.mit.edu	37	chr4	48559529	48559529	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtggcttgtggagatccccAtccttctccccgtaaccagc	9	15	1	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr4:48559529A>C	uc003gyh.1	-	34	4671	c.4066T>G	c.(4066-4068)TGG>GGG	p.W1356G	FRYL_uc003gyk.2_Missense_Mutation_p.W1356G|FRYL_uc003gyg.1_Missense_Mutation_p.W52G|FRYL_uc003gyi.1_Missense_Mutation_p.W245G	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1356					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GGAGATCCCCATCCTTCTCCC	0.423													C	48559529	C	C	48559529	3	2	168	1	0	0	0	0	1	0	0	0	6064	217	8	5	5099	5	FRYL	4	48559529	Missense_Mutation	SNP	A	TCGA-19-5955-01A-11D-1696-08		48559529	142594747	28	11977											
CWH43	80157	broad.mit.edu	37	chr4	49040170	49040170	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctggctccagagattatctAcagctcactgaacatggcaa	8	12	2	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr4:49040170A>C	uc003gyv.2	+	13	1958	c.1776A>C	c.(1774-1776)CTA>CTC	p.L592L	CWH43_uc011bzl.1_Silent_p.L565L	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	592					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						GAGATTATCTACAGCTCACTG	0.323													C	49040170	C	C	49040170	2	2	168	1	0	0	0	0	0	0	0	1	4073	378	14	5		5	CWH43	4	49040170	Silent	SNP	A	TCGA-19-5955-01A-11D-1696-08	480641	49040170	142114106	29	11978											
CSN2	1447	broad.mit.edu	37	chr4	70823249	70823249	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gagcagaggcagaggaagatGcagattttcaagatcagtga	14	5	2	6			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr4:70823249G>T	uc003hes.3	-	5	431	c.418C>A	c.(418-420)CAT>AAT	p.H140N	CSN2_uc003het.3_Missense_Mutation_p.H139N	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	140				H -> Q (in Ref. 3; CAA34916).	calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						AGAGGAAGATGCAGATTTTCA	0.507													T	70823249	T	T	70823249	3	4	168	1	0	0	0	0	1	0	0	0	3948	1319	46	5	270	5	CSN2	4	70823249	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	21783079	70823249	120331027	30	11979											
WDFY3	23001	broad.mit.edu	37	chr4	85719250	85719250	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatttaaaggacttgccaaaCgtaaaaactccctaagaaag	6	8	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr4:85719250C>T	uc003hpd.2	-	18	3242	c.2834G>A	c.(2833-2835)CGT>CAT	p.R945H		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	945						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ACTTGCCAAACGTAAAAACTC	0.313													T	85719250	T	T	85719250	3	4	168	1	0	0	0	0	1	0	0	0	17267	536	19	1	7950	1	WDFY3	4	85719250	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	14896001	85719250	105435026	31	11980											
ADAM29	11086	broad.mit.edu	37	chr4	175898963	175898963	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cttcccagagtcaacctcctGtgacaccctcccagagtcaa	6	17	2	3			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr4:175898963G>C	uc003iuc.2	+	5	2957	c.2287G>C	c.(2287-2289)GTG>CTG	p.V763L	ADAM29_uc003iud.2_Missense_Mutation_p.V763L|ADAM29_uc010irr.2_Missense_Mutation_p.V763L|ADAM29_uc011cki.1_Missense_Mutation_p.V763L	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	763	Cytoplasmic (Potential).|9 X 9 AA approximate repeats.|3.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TCAACCTCCTGTGACACCCTC	0.567													C	175898963	C	C	175898963	3	2	168	1	0	0	0	0	1	0	0	0	247	1377	48	5	2289	5	ADAM29	4	175898963	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	90179713	175898963	15255313	32	11981											
PIK3R1	5295	broad.mit.edu	37	chr5	67591246	67591246	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttttcaaaactgtttttcAggtggttgactcaaaaaggt	8	6	4	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr5:67591246A>G	uc003jva.2	+	14	2306	c.1746_splice	c.e14-2	p.M582_splice	PIK3R1_uc003jvb.2_Splice_Site_p.M582_splice|PIK3R1_uc003jvc.2_Splice_Site_p.M282_splice|PIK3R1_uc003jvd.2_Splice_Site_p.M312_splice|PIK3R1_uc003jve.2_Splice_Site_p.M261_splice|PIK3R1_uc011crb.1_Splice_Site_p.M252_splice	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(2)|p.Y580fs*1(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	ACTGTTTTTCAGGTGGTTGAC	0.363			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			G	67591246	G	G	67591246	5	3	168	1	0	0	0	0	0	0	1	0	11918	202	7	4	1924	4	PIK3R1	5	67591246	Splice_Site	SNP	A	TCGA-19-5955-01A-11D-1696-08		67591246	113324014	33	11982											
SLCO6A1	133482	broad.mit.edu	37	chr5	101709074	101709074	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agttacaagtcagtttcttcTtttttcttaacttttggatt	5	6	4	0	rs146381310	byFrequency	TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr5:101709074T>C	uc003knn.2	-	13	2314	c.2142A>G	c.(2140-2142)AAA>AAG	p.K714K	SLCO6A1_uc003kno.2_Silent_p.K461K|SLCO6A1_uc003knp.2_Silent_p.K714K|SLCO6A1_uc003knq.2_Silent_p.K652K	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	714	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CAGTTTCTTCTTTTTTCTTAA	0.269													C	101709074	C	C	101709074	2	2	168	1	0	0	0	0	0	0	0	1	14732	1606	56	4		4	SLCO6A1	5	101709074	Silent	SNP	T	TCGA-19-5955-01A-11D-1696-08	34117828	101709074	79206186	34	11983											
PCDHA11	56138	broad.mit.edu	37	chr5	140249928	140249928	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgctggacagcgccctggacCgcgagaacgtgtgggcctat	15	12	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr5:140249928C>A	uc003lia.2	+	1	2098	c.1240C>A	c.(1240-1242)CGC>AGC	p.R414S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R414S	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	414	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCCTGGACCGCGAGAACGT	0.627													A	140249928	A	A	140249928	3	1	168	1	0	0	0	0	1	0	0	0	11521	652	23	5	1242	5	PCDHA11	5	140249928	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	38540854	140249928	40665332	35	11984											
PCDHA11	56138	broad.mit.edu	37	chr5	140250294	140250294	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctacagttccaggtgagcGcgcgcgatgcgggcgtgccg	17	12	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr5:140250294G>A	uc003lia.2	+	1	2464	c.1606G>A	c.(1606-1608)GCG>ACG	p.A536T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.A536T	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	536	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGGTGAGCGCGCGCGATGC	0.672													A	140250294	A	A	140250294	3	1	168	1	0	0	0	0	1	0	0	0	11521	1087	38	1	1608	1	PCDHA11	5	140250294	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	366	140250294	40664966	36	11985											
PCDHB7	56129	broad.mit.edu	37	chr5	140553185	140553185	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtgcccgaaaatagccccGttggttccatggttgtctcc	11	12	1	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr5:140553185G>A	uc003lit.2	+	1	943	c.769G>A	c.(769-771)GTT>ATT	p.V257I		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	257	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATAGCCCCGTTGGTTCCAT	0.502													A	140553185	A	A	140553185	3	1	168	1	0	0	0	0	1	0	0	0	11547	1145	40	1	771	1	PCDHB7	5	140553185	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	302891	140553185	40362075	37	11986											
PCDHB14	56122	broad.mit.edu	37	chr5	140605446	140605446	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggggaaatcgagaactttcGaaatagctttggacttaaca	11	6	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr5:140605446G>A	uc003ljb.2	+	1	2369	c.2369G>A	c.(2368-2370)CGA>CAA	p.R790Q	PCDHB14_uc011dal.1_Missense_Mutation_p.R637Q	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	790	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGAACTTTCGAAATAGCTTT	0.348													A	140605446	A	A	140605446	3	1	168	1	0	0	0	0	1	0	0	0	11539	1058	37	2	2371	2	PCDHB14	5	140605446	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	52261	140605446	40309814	38	11987											
BTBD9	114781	broad.mit.edu	37	chr6	38256068	38256068	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtattgacccaatcatgtaCggttgtgccaactgaaccac	8	12	1	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr6:38256068C>T	uc003ooa.3	-	9	2010	c.1434G>A	c.(1432-1434)CCG>CCA	p.P478P	BTBD9_uc003ony.3_Silent_p.P410P|BTBD9_uc010jwv.2_Silent_p.P439P|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Silent_p.P478P	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	478					cell adhesion						0						CAATCATGTACGGTTGTGCCA	0.398													T	38256068	T	T	38256068	2	4	168	1	0	0	0	0	0	0	0	1	1548	523	19	1		1	BTBD9	6	38256068	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08		38256068	132858999	39	11988											
PKHD1	5314	broad.mit.edu	37	chr6	51524416	51524416	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agaagacgtgggggctctggAgctcatggtagaatacagcc	15	8	2	3			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr6:51524416A>G	uc003pah.1	-	61	10784	c.10508T>C	c.(10507-10509)CTC>CCC	p.L3503P		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3503	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGGGCTCTGGAGCTCATGGTA	0.438													G	51524416	G	G	51524416	3	3	168	1	0	0	0	0	1	0	0	0	11971	304	11	4	1744	4	PKHD1	6	51524416	Missense_Mutation	SNP	A	TCGA-19-5955-01A-11D-1696-08	13268348	51524416	119590651	40	11989											
DOPEY1	23033	broad.mit.edu	37	chr6	83847935	83847935	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctctgccatcaaagccatcTtgaaaactaaccctatagct	4	13	3	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr6:83847935T>C	uc003pjs.1	+	21	4434	c.4174T>C	c.(4174-4176)TTG>CTG	p.L1392L	DOPEY1_uc011dyy.1_Silent_p.L1383L|DOPEY1_uc010kbl.1_Silent_p.L1383L|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1392					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CAAAGCCATCTTGAAAACTAA	0.383													C	83847935	C	C	83847935	2	2	168	1	0	0	0	0	0	0	0	1	4707	1606	56	4		4	DOPEY1	6	83847935	Silent	SNP	T	TCGA-19-5955-01A-11D-1696-08	32323519	83847935	87267132	41	11990											
IKZF1	10320	broad.mit.edu	37	chr7	50468241	50468241	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttccgtgatccttttgagtgCaacatgtgcggctaccacag	10	11	0	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr7:50468241C>A	uc003tow.3	+	9	1644	c.1476C>A	c.(1474-1476)TGC>TGA	p.C492*	IKZF1_uc003tox.3_Nonsense_Mutation_p.C450*|IKZF1_uc003toy.3_Nonsense_Mutation_p.C450*|IKZF1_uc011kck.1_Nonsense_Mutation_p.C405*|IKZF1_uc003toz.3_Nonsense_Mutation_p.C462*|IKZF1_uc010kyx.2_Nonsense_Mutation_p.C232*|IKZF1_uc003tpa.3_Nonsense_Mutation_p.C234*	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	492	C2H2-type 6.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CTTTTGAGTGCAACATGTGCG	0.592			D		ALL								A	50468241	A	A	50468241	4	1	168	1	0	0	0	0	0	1	0	0	7614	718	25	5	1502	5	IKZF1	7	50468241	Nonsense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08		50468241	108670422	42	11991											
BAIAP2L1	55971	broad.mit.edu	37	chr7	97944874	97944874	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agagcctctttgcaaccatcTgcaatgaatttctggatttc	7	10	3	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr7:97944874T>C	uc003upj.2	-	7	800	c.537A>G	c.(535-537)GCA>GCG	p.A179A		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	179	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			TGCAACCATCTGCAATGAATT	0.358													C	97944874	C	C	97944874	2	2	168	1	0	0	0	0	0	0	0	1	1302	1567	55	4		4	BAIAP2L1	7	97944874	Silent	SNP	T	TCGA-19-5955-01A-11D-1696-08	47476633	97944874	61193789	43	11992											
CLDN15	24146	broad.mit.edu	37	chr7	100877603	100877603	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cggtggccgccagcttggctTtcctggagagctccaggccc	14	15	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr7:100877603T>C	uc003uyg.1	-	2	592	c.338A>G	c.(337-339)AAA>AGA	p.K113R	CLDN15_uc003uyh.1_Missense_Mutation_p.K113R|CLDN15_uc003uyi.2_3'UTR	NM_014343	NP_055158	P56746	CLD15_HUMAN	claudin 15	113	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					CAGCTTGGCTTTCCTGGAGAG	0.662													C	100877603	C	C	100877603	3	2	168	1	0	0	0	0	1	0	0	0	3476	1841	64	4	364	4	CLDN15	7	100877603	Missense_Mutation	SNP	T	TCGA-19-5955-01A-11D-1696-08	2932729	100877603	58261060	44	11993											
GRM8	2918	broad.mit.edu	37	chr7	126409978	126409978	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcccatcaatggtactcattCgtggacaaaggccaatgtat	8	10	2	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr7:126409978C>T	uc003vlr.2	-	6	1609	c.1298G>A	c.(1297-1299)CGA>CAA	p.R433Q	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.R433Q|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.R154Q	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	433	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GGTACTCATTCGTGGACAAAG	0.403										HNSCC(24;0.065)			T	126409978	T	T	126409978	3	4	168	1	0	0	0	0	1	0	0	0	6803	884	31	2	1498	2	GRM8	7	126409978	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	25532375	126409978	32728685	45	11994											
STC1	6781	broad.mit.edu	37	chr8	23702306	23702306	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcactctcatgggatgtgcGtttgatgtgggagggagagt	17	5	1	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr8:23702306G>A	uc003xdw.1	-	4	1005	c.721C>T	c.(721-723)CGC>TGC	p.R241C		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor	241					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TGGGATGTGCGTTTGATGTGG	0.507													A	23702306	A	A	23702306	3	1	168	1	0	0	0	0	1	0	0	0	15274	1145	40	1	26	1	STC1	8	23702306	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08		23702306	122661716	46	11995											
EBF2	64641	broad.mit.edu	37	chr8	25718727	25718727	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagcaatgtctgcggctcGcttcaaaatgatgtcctaca	8	11	3	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr8:25718727G>A	uc003xes.1	-	13	1197	c.1180C>T	c.(1180-1182)CGA>TGA	p.R394*	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	394					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TCTGCGGCTCGCTTCAAAATG	0.488													A	25718727	A	A	25718727	4	1	168	1	0	0	0	0	0	1	0	0	4881	1095	38	1	563	1	EBF2	8	25718727	Nonsense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	2016421	25718727	120645295	47	11996											
LYN	4067	broad.mit.edu	37	chr8	56866431	56866431	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaagattggagaaggcttgTattagtcccaagccacagaa	11	7	0	4			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr8:56866431T>C	uc003xsk.3	+	8	960	c.678T>C	c.(676-678)TGT>TGC	p.C226C	LYN_uc003xsl.3_Silent_p.C205C	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	226	SH2.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			AGAAGGCTTGTATTAGTCCCA	0.478													C	56866431	C	C	56866431	2	2	168	1	0	0	0	0	0	0	0	1	9107	1644	57	4		4	LYN	8	56866431	Silent	SNP	T	TCGA-19-5955-01A-11D-1696-08	31147704	56866431	89497591	48	11997											
PRDM14	63978	broad.mit.edu	37	chr8	70980585	70980585	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgcagaacacaccaaaatgTgggacttcaccaaacaccgt	7	13	1	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr8:70980585T>C	uc003xym.2	-	4	994	c.792A>G	c.(790-792)CCA>CCG	p.P264P		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	264	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CACCAAAATGTGGGACTTCAC	0.488													C	70980585	C	C	70980585	2	2	168	1	0	0	0	0	0	0	0	1	12455	1683	59	4		4	PRDM14	8	70980585	Silent	SNP	T	TCGA-19-5955-01A-11D-1696-08	14114154	70980585	75383437	49	11998											
PABPC1	26986	broad.mit.edu	37	chr8	101730507	101730507	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggtgtccaaagcacgctcCgctgcaggaaggacattttc	11	11	0	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr8:101730507C>T	uc003yjs.1	-	2	699	c.195G>A	c.(193-195)GCG>GCA	p.A65A	PABPC1_uc011lhc.1_Silent_p.A65A|PABPC1_uc011lhd.1_Silent_p.A20A|PABPC1_uc003yjt.1_Silent_p.A65A|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	65	RRM 1.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			AAGCACGCTCCGCTGCAGGAA	0.433													T	101730507	T	T	101730507	2	4	168	1	0	0	0	0	0	0	0	1	11363	666	23	2		2	PABPC1	8	101730507	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08	30749922	101730507	44633515	50	11999											
RIMS2	9699	broad.mit.edu	37	chr8	104778688	104778688	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtggagaaaagtcgatctcaTgggctcacaagacagcattc	11	9	2	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr8:104778688T>C	uc003ylp.2	+	3	760	c.621T>C	c.(619-621)CAT>CAC	p.H207H		NM_001100117	NP_001093587	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	238					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTCGATCTCATGGGCTCACAA	0.443										HNSCC(12;0.0054)			C	104778688	C	C	104778688	2	2	168	1	0	0	0	0	0	0	0	1	13368	1461	51	4		4	RIMS2	8	104778688	Silent	SNP	T	TCGA-19-5955-01A-11D-1696-08	3048181	104778688	41585334	51	12000											
FREM1	158326	broad.mit.edu	37	chr9	14775892	14775892	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagcagtcagtctgggagtcCcctcctgagtgccgataggc	13	12	2	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr9:14775892C>T	uc003zlm.2	-	25	5342	c.4752G>A	c.(4750-4752)GGG>GGA	p.G1584G	FREM1_uc010mic.2_Intron|FREM1_uc003zlk.2_5'Flank|FREM1_uc003zll.2_Silent_p.G120G	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1584	CSPG 11.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TCTGGGAGTCCCCTCCTGAGT	0.512													T	14775892	T	T	14775892	2	4	168	1	0	0	0	0	0	0	0	1	6044	610	22	3		3	FREM1	9	14775892	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08		14775892	126437539	52	12001											
RRAGA	10670	broad.mit.edu	37	chr9	19050342	19050342	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	agcgcgacgtccaccggtttGagaagatcagcaacatcatc	10	12	2	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr9:19050342G>A	uc003znj.2	+	1	971	c.685G>A	c.(685-687)GAG>AAG	p.E229K		NM_006570	NP_006561	Q7L523	RRAGA_HUMAN	Ras-related GTP binding A	229				E -> G (in Ref. 2; AAB63255).	apoptosis|cellular protein localization|cellular response to amino acid stimulus|positive regulation of cytolysis|positive regulation of TOR signaling cascade|virus-host interaction	Golgi apparatus|lysosome|nucleus	GTP binding|phosphoprotein binding|protein heterodimerization activity|protein homodimerization activity				0						CCACCGGTTTGAGAAGATCAG	0.473													A	19050342	A	A	19050342	3	1	168	1	0	0	0	0	1	0	0	0	13672	1291	45	3	687	3	RRAGA	9	19050342	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	4274450	19050342	122163089	53	12002											
TAF1L	138474	broad.mit.edu	37	chr9	32632340	32632340	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgacattcctctttgtaacGctcttgatgctcagccacag	7	13	3	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr9:32632340G>A	uc003zrg.1	-	1	3328	c.3238C>T	c.(3238-3240)CGT>TGT	p.R1080C	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1080					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCTTTGTAACGCTCTTGATGC	0.473													A	32632340	A	A	32632340	3	1	168	1	0	0	0	0	1	0	0	0	15520	1087	38	1	2246	1	TAF1L	9	32632340	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	13581998	32632340	108581091	54	12003											
FGD3	89846	broad.mit.edu	37	chr9	95738835	95738835	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggagggcttggaggctggCccaagccccactgtactggg	17	11	0	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr9:95738835C>T	uc004asw.2	+	3	925	c.297C>T	c.(295-297)GGC>GGT	p.G99G	FGD3_uc004asx.2_Silent_p.G99G|FGD3_uc004asz.2_Silent_p.G99G	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	99					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						TGGAGGCTGGCCCAAGCCCCA	0.657													T	95738835	T	T	95738835	2	4	168	1	0	0	0	0	0	0	0	1	5834	726	26	3		3	FGD3	9	95738835	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08	63106495	95738835	45474596	55	12004											
ASTN2	23245	broad.mit.edu	37	chr9	119488220	119488220	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggtcaggatcttgagaacaTtagtgaagcctggacaagag	13	6	2	3			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr9:119488220T>C	uc004bjs.1	-	16	2737	c.2636A>G	c.(2635-2637)AAT>AGT	p.N879S	ASTN2_uc004bjr.1_Missense_Mutation_p.N875S|ASTN2_uc004bjt.1_Missense_Mutation_p.N828S	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	879	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CTTGAGAACATTAGTGAAGCC	0.542													C	119488220	C	C	119488220	3	2	168	1	0	0	0	0	1	0	0	0	1065	1493	52	4	1647	4	ASTN2	9	119488220	Missense_Mutation	SNP	T	TCGA-19-5955-01A-11D-1696-08	23749385	119488220	21725211	56	12005											
FCN2	2220	broad.mit.edu	37	chr9	137777089	137777089	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggttcccttcccaggcccGcgtacctgcaaggacctgct	11	17	0	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr9:137777089G>A	uc004cfg.1	+	5	316	c.306G>A	c.(304-306)CCG>CCA	p.P102P	FCN2_uc004cfh.1_Silent_p.P64P	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	102	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		TCCCAGGCCCGCGTACCTGCA	0.662													A	137777089	A	A	137777089	2	1	168	1	0	0	0	0	0	0	0	1	5792	1074	38	1		1	FCN2	9	137777089	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	18288869	137777089	3436342	57	12006											
MYO3A	53904	broad.mit.edu	37	chr10	26315330	26315330	+	Frame_Shift_Del	DEL	G	-	-													ttgactaaagattatgaaaaGcgtccaacagtgtcagaact							TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr10:26315330delG	uc001isn.2	+	10	1182	c.822delG	c.(820-822)AAGfs	p.K274fs	MYO3A_uc009xko.1_Frame_Shift_Del_p.K274fs|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Frame_Shift_Del_p.K274fs	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	274	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						ATTATGAAAAGCGTCCAACAG	0.328													-	26315330	-	-	26315330	7	5	168	1	0	1	0	1	0	0	0	0	10076	962	34	0	852	0	MYO3A	10	26315330	Frame_Shift_Del	DEL	G	TCGA-19-5955-01A-11D-1696-08		26315330	109219417	58	12007											
PTEN	5728	broad.mit.edu	37	chr10	89725130	89725130	+	Frame_Shift_Del	DEL	C	-	-													gtaacaccagatgttagtgaCaatgaacctgatcattatag							TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr10:89725130delC	uc001kfb.2	+	10	2144	c.1113delC	c.(1111-1113)GACfs	p.D371fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	371					activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.Y27fs*1(2)|p.N212fs*1(2)|p.G165_*404del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ATGTTAGTGACAATGAACCTG	0.388		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89725130	-	-	89725130	7	5	168	1	0	1	0	1	0	0	0	0	12738	477	17	0	1147	0	PTEN	10	89725130	Frame_Shift_Del	DEL	C	TCGA-19-5955-01A-11D-1696-08	63409800	89725130	45809617	59	12008											
HTR7	3363	broad.mit.edu	37	chr10	92508680	92508680	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagcttccggttgatattcCggtactggcactggagcagg	14	9	0	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr10:92508680C>T	uc001kha.2	-	2	1454	c.1211G>A	c.(1210-1212)CGG>CAG	p.R404Q	HTR7_uc001kgz.2_Missense_Mutation_p.R404Q|HTR7_uc001khb.2_Missense_Mutation_p.R404Q	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	404	Cytoplasmic (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	GTTGATATTCCGGTACTGGCA	0.507													T	92508680	T	T	92508680	3	4	168	1	0	0	0	0	1	0	0	0	7452	652	23	2	244	2	HTR7	10	92508680	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	2783550	92508680	43026067	60	12009											
OR4D10	390197	broad.mit.edu	37	chr11	59245250	59245250	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggatgtattttctctttcGgtgatggcattggatcgata	12	5	1	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr11:59245250G>A	uc001nnz.1	+	1	348	c.348G>A	c.(346-348)TCG>TCA	p.S116S		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TTTCTCTTTCGGTGATGGCAT	0.473													A	59245250	A	A	59245250	2	1	168	1	0	0	0	0	0	0	0	1	11054	1103	39	2		2	OR4D10	11	59245250	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08		59245250	75761266	61	12010											
ATM	472	broad.mit.edu	37	chr11	108199882	108199882	+	Frame_Shift_Del	DEL	G	-	-													gaaaactacatgaaatcatcGgaatttgaaaacaagcaagc					rs145747513	byFrequency	TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr11:108199882delG	uc001pkb.1	+	49	7609	c.7224delG	c.(7222-7224)TCGfs	p.S2408fs	ATM_uc009yxr.1_Frame_Shift_Del_p.S2408fs|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Frame_Shift_Del_p.S1060fs|ATM_uc001pkg.1_Frame_Shift_Del_p.S765fs	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2408	FAT.		S -> L (in a colorectal adenocarcinoma sample; somatic mutation).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.S2408L(1)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TGAAATCATCGGAATTTGAAA	0.373			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			-	108199882	-	-	108199882	7	5	168	1	0	1	0	1	0	0	0	0	1109	1103	39	0	7414	0	ATM	11	108199882	Frame_Shift_Del	DEL	G	TCGA-19-5955-01A-11D-1696-08	48954632	108199882	26806634	62	12011											
ST8SIA1	6489	broad.mit.edu	37	chr12	22354787	22354787	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagaactttccaatgctaCgcagaaagttggggttggca	11	9	0	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr12:22354787C>T	uc001rfo.3	-	5	1252	c.770G>A	c.(769-771)CGT>CAT	p.R257H	ST8SIA1_uc009zix.2_Missense_Mutation_p.R114H	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	257	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						TCCAATGCTACGCAGAAAGTT	0.478													T	22354787	T	T	22354787	3	4	168	1	0	0	0	0	1	0	0	0	15230	536	19	1	304	1	ST8SIA1	12	22354787	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08		22354787	111497108	63	12012											
SRGAP1	57522	broad.mit.edu	37	chr12	64502748	64502748	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagagggcgcttcacatccGcaaactcctcctgactttgc	9	14	1	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr12:64502748G>A	uc010ssp.1	+	16	1906	c.1850G>A	c.(1849-1851)CGC>CAC	p.R617H	SRGAP1_uc001srv.2_Missense_Mutation_p.R554H	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	617	Rho-GAP.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		CTTCACATCCGCAAACTCCTC	0.463													A	64502748	A	A	64502748	3	1	168	1	0	0	0	0	1	0	0	0	15144	1087	38	1	1912	1	SRGAP1	12	64502748	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	42147961	64502748	69349147	64	12013											
GRIP1	23426	broad.mit.edu	37	chr12	66765507	66765507	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	acaggagttggagacatgatCtcctttatttcttgtttcat	8	7	3	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr12:66765507C>T	uc001stk.2	-	22	3064	c.2823G>A	c.(2821-2823)GAG>GAA	p.E941E	GRIP1_uc010sta.1_Silent_p.E885E|GRIP1_uc001stj.2_Silent_p.E708E|GRIP1_uc001stl.1_Silent_p.E818E|GRIP1_uc001stm.2_Silent_p.E926E	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	993					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		GAGACATGATCTCCTTTATTT	0.493													T	66765507	T	T	66765507	2	4	168	1	0	0	0	0	0	0	0	1	6787	912	32	3		3	GRIP1	12	66765507	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08	2262759	66765507	67086388	65	12014											
C12orf43	64897	broad.mit.edu	37	chr12	121444130	121444130	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtataaccactcaccatcatCctccaaagcgactttctgta	4	14	3	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr12:121444130C>T	uc001tzh.1	-	4	378	c.355G>A	c.(355-357)GAT>AAT	p.D119N	C12orf43_uc009zxa.1_Missense_Mutation_p.D150N|C12orf43_uc010szo.1_Missense_Mutation_p.D77N|C12orf43_uc010szp.1_Missense_Mutation_p.D119N|C12orf43_uc001tzi.1_Missense_Mutation_p.D119N	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	119											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCACCATCATCCTCCAAAGCG	0.284													T	121444130	T	T	121444130	3	4	168	1	0	0	0	0	1	0	0	0	1689	855	30	3	445	3	C12orf43	12	121444130	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	54678623	121444130	12407765	66	12015											
RNF17	56163	broad.mit.edu	37	chr13	25419167	25419167	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttaagaaaacttgaagaaaaTctaaagacaatgggaagact	8	4	1	5			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr13:25419167T>A	uc001upr.2	+	22	3092	c.3051T>A	c.(3049-3051)AAT>AAA	p.N1017K	RNF17_uc010tdd.1_Missense_Mutation_p.N876K|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.N1017K|RNF17_uc001ups.2_Missense_Mutation_p.N956K|RNF17_uc010aac.2_Missense_Mutation_p.N215K|RNF17_uc010aad.2_Missense_Mutation_p.N69K	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1017	Tudor 2.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTGAAGAAAATCTAAAGACAA	0.308													A	25419167	A	A	25419167	3	1	168	1	0	0	0	0	1	0	0	0	13461	1432	50	5	3137	5	RNF17	13	25419167	Missense_Mutation	SNP	T	TCGA-19-5955-01A-11D-1696-08		25419167	89750711	67	12016											
TEP1	7011	broad.mit.edu	37	chr14	20873722	20873722	+	Missense_Mutation	SNP	C	G	G													cttctgagaccagagtagagCacagcaagctcagtagagcc							TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr14:20873722C>G	uc001vxe.2	-	4	798	c.758G>C	c.(757-759)TGC>TCC	p.C253S	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.C253S	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	253	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CAGAGTAGAGCACAGCAAGCT	0.468													G	20873722	G	G	20873722	3	3	168	1	0	0	0	0	1	0	0	0	15756	710	25	5	7333	5	TEP1	14	20873722	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08		20873722	86475818	68	12017	15	2									
TEP1	7011	broad.mit.edu	37	chr14	20873724	20873724	+	Silent	SNP	C	G	G													tctgagaccagagtagagcaCagcaagctcagtagagccat							TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr14:20873724C>G	uc001vxe.2	-	4	796	c.756G>C	c.(754-756)CTG>CTC	p.L252L	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.L252L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	252	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GAGTAGAGCACAGCAAGCTCA	0.463													G	20873724	G	G	20873724	2	3	168	1	0	0	0	0	0	0	0	1	15756	465	17	5		5	TEP1	14	20873724	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08	2	20873724	86475816	69	12018	15	2									
NOVA1	4857	broad.mit.edu	37	chr14	26941562	26941562	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtggtcatgggatcagatggAgaggacttggtggtagttgg	19	3	2	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr14:26941562A>C	uc001wpy.2	-	4	801	c.483T>G	c.(481-483)TCT>TCG	p.S161S	NOVA1_uc001wpz.2_Intron|NOVA1_uc001wqa.2_Silent_p.S39S|NOVA1_uc001wqb.2_Silent_p.S161S	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	164					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		GATCAGATGGAGAGGACTTGG	0.428													C	26941562	C	C	26941562	2	2	168	1	0	0	0	0	0	0	0	1	10554	291	11	5		5	NOVA1	14	26941562	Silent	SNP	A	TCGA-19-5955-01A-11D-1696-08	6067838	26941562	80407978	70	12019											
RTN1	6252	broad.mit.edu	37	chr14	60212931	60212931	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tccgtggactctgcaggagtCatctctattccagaatcaga	9	11	4	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr14:60212931C>G	uc001xen.1	-	2	719	c.510G>C	c.(508-510)ATG>ATC	p.M170I		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	170					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		CTGCAGGAGTCATCTCTATTC	0.512													G	60212931	G	G	60212931	3	3	168	1	0	0	0	0	1	0	0	0	13725	826	29	5	1917	5	RTN1	14	60212931	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	33271369	60212931	47136609	71	12020											
RTN1	6252	broad.mit.edu	37	chr14	60213169	60213169	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgttgttgagaaggtgTggtccatggcactggaaaca	14	5	0	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr14:60213169T>C	uc001xen.1	-	2	481	c.272A>G	c.(271-273)CAC>CGC	p.H91R		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	91					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TGAGAAGGTGTGGTCCATGGC	0.478													C	60213169	C	C	60213169	3	2	168	1	0	0	0	0	1	0	0	0	13725	1696	59	4	2155	4	RTN1	14	60213169	Missense_Mutation	SNP	T	TCGA-19-5955-01A-11D-1696-08	238	60213169	47136371	72	12021											
SYNE2	23224	broad.mit.edu	37	chr14	64430685	64430685	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctacagaagttgctaaaggaTtcagagaatgatacctactt	8	7	1	3			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr14:64430685T>C	uc001xgm.2	+	10	1187	c.957T>C	c.(955-957)GAT>GAC	p.D319D	SYNE2_uc001xgl.2_Silent_p.D319D	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	319	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGCTAAAGGATTCAGAGAATG	0.308													C	64430685	C	C	64430685	2	2	168	1	0	0	0	0	0	0	0	1	15443	1490	52	4		4	SYNE2	14	64430685	Silent	SNP	T	TCGA-19-5955-01A-11D-1696-08	4217516	64430685	42918855	73	12022											
NEDD4	4734	broad.mit.edu	37	chr15	56132880	56132880	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagtaagagaggtgatcttcGttacacaatccagagtttgg	11	6	1	3			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr15:56132880G>A	uc002adj.2	-	16	3441	c.3141C>T	c.(3139-3141)AAC>AAT	p.N1047N	NEDD4_uc002adl.2_Silent_p.N628N|NEDD4_uc002adi.2_Silent_p.N975N|NEDD4_uc010ugj.1_Silent_p.N1031N|NEDD4_uc010bfm.2_Silent_p.N1030N|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1047	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		GGTGATCTTCGTTACACAATC	0.338													A	56132880	A	A	56132880	2	1	168	1	0	0	0	0	0	0	0	1	10310	1136	40	1		1	NEDD4	15	56132880	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08		56132880	46398512	74	12023											
HS3ST6	64711	broad.mit.edu	37	chr16	1962204	1962204	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccagggttcggggcatcagaCtcctgcgggacgggtgcaag	17	11	1	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr16:1962204C>A	uc002cnf.2	-	2	323	c.323G>T	c.(322-324)AGT>ATT	p.S108I		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	108											0						GGGCATCAGACTCCTGCGGGA	0.706													A	1962204	A	A	1962204	3	1	168	1	0	0	0	0	1	0	0	0	7369	565	20	5	616	5	HS3ST6	16	1962204	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08		1962204	88392549	75	12024											
PHF12	57649	broad.mit.edu	37	chr17	27240276	27240276	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaatatgctgcactggagcGcaacaacactacagagccac	8	13	1	1	rs141809044		TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr17:27240276G>A	uc002hdg.1	-	9	1843	c.1313C>T	c.(1312-1314)GCG>GTG	p.A438V	PHF12_uc010wbb.1_Missense_Mutation_p.A420V|PHF12_uc002hdi.1_Missense_Mutation_p.A434V|PHF12_uc002hdj.1_Missense_Mutation_p.A438V|PHF12_uc010crw.1_Missense_Mutation_p.A141V|PHF12_uc002hdh.1_Missense_Mutation_p.A221V	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	438	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			GCACTGGAGCGCAACAACACT	0.532													A	27240276	A	A	27240276	3	1	168	1	0	0	0	0	1	0	0	0	11823	1087	38	1	1755	1	PHF12	17	27240276	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08		27240276	53954934	76	12025											
ACACA	31	broad.mit.edu	37	chr17	35633950	35633950	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcaatgccatttttcaAgagaagttccggtagtttgg	12	6	1	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr17:35633950A>G	uc002hnm.2	-	7	858	c.667T>C	c.(667-669)TTG>CTG	p.L223L	ACACA_uc002hnk.2_Silent_p.L145L|ACACA_uc002hnl.2_Silent_p.L165L|ACACA_uc002hnn.2_Silent_p.L223L|ACACA_uc002hno.2_Silent_p.L260L|ACACA_uc010cuz.2_Silent_p.L223L|ACACA_uc002hnq.2_Silent_p.L145L	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	223	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CCATTTTTCAAGAGAAGTTCC	0.403													G	35633950	G	G	35633950	2	3	168	1	0	0	0	0	0	0	0	1	106	69	3	4		4	ACACA	17	35633950	Silent	SNP	A	TCGA-19-5955-01A-11D-1696-08	8393674	35633950	45561260	77	12026											
KRTAP4-7	100132476	broad.mit.edu	37	chr17	39240673	39240673	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgccccacctgctgtgagaCgacctgctgccaccctaggt	10	17	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr17:39240673C>T	uc010wfn.1	+	1	215	c.215C>T	c.(214-216)ACG>ATG	p.T72M		NM_033061	NP_149050			keratin associated protein 4-7												0						TGCTGTGAGACGACctgctgc	0.338													T	39240673	T	T	39240673	3	4	168	1	0	0	0	0	1	0	0	0	8555	536	19	1	217	1	KRTAP4-7	17	39240673	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	3606723	39240673	41954537	78	12027											
COL1A1	1277	broad.mit.edu	37	chr17	48263379	48263379	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagccctggccgccatactcGaactgcaggggaggggagag	17	11	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr17:48263379G>A	uc002iqm.2	-	50	4134	c.4008C>T	c.(4006-4008)TTC>TTT	p.F1336F		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	1336	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	CGCCATACTCGAACTGCAGGG	0.637			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						A	48263379	A	A	48263379	2	1	168	1	0	0	0	0	0	0	0	1	3677	1049	37	2		2	COL1A1	17	48263379	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	9022706	48263379	32931831	79	12028											
ABCC3	8714	broad.mit.edu	37	chr17	48757178	48757178	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgacatttgctctgaactGgatgatacgaatgatgtcag	12	6	2	4			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr17:48757178G>A	uc002isl.2	+	26	3805	c.3725G>A	c.(3724-3726)TGG>TAG	p.W1242*	ABCC3_uc002isn.2_5'UTR	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1242	ABC transmembrane type-1 2.|Helical; Name=17; (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GCTCTGAACTGGATGATACGA	0.517													A	48757178	A	A	48757178	4	1	168	1	0	0	0	0	0	1	0	0	54	1357	47	3	3911	3	ABCC3	17	48757178	Nonsense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	493799	48757178	32438032	80	12029											
SOX9	6662	broad.mit.edu	37	chr17	70120351	70120351	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccagaactccagctcctaCtacagccacgcggcaggcca	8	18	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr17:70120351C>T	uc002jiw.2	+	3	1725	c.1353C>T	c.(1351-1353)TAC>TAT	p.Y451Y		NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	451					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CCAGCTCCTACTACAGCCACG	0.637													T	70120351	T	T	70120351	2	4	168	1	0	0	0	0	0	0	0	1	14958	576	20	3		3	SOX9	17	70120351	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08	21363173	70120351	11074859	81	12030											
SEPT9	10801	broad.mit.edu	37	chr17	75398771	75398771	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgtggctgaggctacacCccggagccaggagggtgagt	16	12	0	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr17:75398771C>T	uc002jts.3	+	3	833	c.707C>T	c.(706-708)CCC>CTC	p.P236L	SEPT9_uc010wtk.1_Missense_Mutation_p.P217L|SEPT9_uc002jtt.3_Missense_Mutation_p.P72L|SEPT9_uc002jtu.3_Missense_Mutation_p.P218L|SEPT9_uc002jtv.2_Missense_Mutation_p.P229L|SEPT9_uc002jtw.2_Missense_Mutation_p.P72L|SEPT9_uc002jtx.1_Missense_Mutation_p.P72L|SEPT9_uc010wtl.1_5'Flank	NM_001113491	NP_001106963	Q9UHD8	SEPT9_HUMAN	septin 9 isoform a	236					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding|protein binding			breast(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(99;0.153)			GAGGCTACACCCCGGAGCCAG	0.627													T	75398771	T	T	75398771	3	4	168	1	0	0	0	0	1	0	0	0	14071	623	22	3	802	3	SEPT9	17	75398771	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	5278420	75398771	5796439	82	12031											
GAA	2548	broad.mit.edu	37	chr17	78083809	78083809	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacgacgagggtctgcggagGggggttttcatcaccaacga	15	9	3	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr17:78083809G>A	uc002jxo.2	+	10	1574	c.1392G>A	c.(1390-1392)AGG>AGA	p.R464R	GAA_uc002jxp.2_Silent_p.R464R|GAA_uc002jxq.2_Silent_p.R464R	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	464					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GTCTGCGGAGGGGGGTTTTCA	0.657													A	78083809	A	A	78083809	2	1	168	1	0	0	0	0	0	0	0	1	6147	1223	43	3		3	GAA	17	78083809	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	2685038	78083809	3111401	83	12032											
SMCHD1	23347	broad.mit.edu	37	chr18	2700844	2700844	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttccaggtcagcacaaataaAttgacgtttatggatcttga	8	7	2	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr18:2700844A>C	uc002klm.3	+	12	1764	c.1575A>C	c.(1573-1575)AAA>AAC	p.K525N	SMCHD1_uc002klk.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	525					chromosome organization		ATP binding				0						GCACAAATAAATTGACGTTTA	0.338													C	2700844	C	C	2700844	3	2	168	1	0	0	0	0	1	0	0	0	14788	98	4	5	1621	5	SMCHD1	18	2700844	Missense_Mutation	SNP	A	TCGA-19-5955-01A-11D-1696-08		2700844	75376404	84	12033											
CIDEA	1149	broad.mit.edu	37	chr18	12274238	12274238	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagatgtactccgtgtcctaCgacatccggtgcacgggact	12	12	0	1	rs143526030	byFrequency	TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr18:12274238C>T	uc002kqt.3	+	4	542	c.477C>T	c.(475-477)TAC>TAT	p.Y159Y	CIDEA_uc002kqu.3_Silent_p.Y193Y|CIDEA_uc010dlc.2_RNA	NM_001279	NP_001270	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a isoform	159					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			ovary(1)|central_nervous_system(1)	2						CCGTGTCCTACGACATCCGGT	0.587													T	12274238	T	T	12274238	2	4	168	1	0	0	0	0	0	0	0	1	3425	547	19	1		1	CIDEA	18	12274238	Silent	SNP	C	TCGA-19-5955-01A-11D-1696-08	9573394	12274238	65803010	85	12034											
TICAM1	148022	broad.mit.edu	37	chr19	4817811	4817811	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctgccagtggatcgcagGgagcacccttggctccagtc	15	13	0	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr19:4817811G>A	uc002mbi.2	-	2	830	c.579C>T	c.(577-579)TCC>TCT	p.S193S		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	193					apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		TGGATCGCAGGGAGCACCCTT	0.652													A	4817811	A	A	4817811	2	1	168	1	0	0	0	0	0	0	0	1	15889	1219	43	3		3	TICAM1	19	4817811	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08		4817811	54311172	86	12035											
MUC16	94025	broad.mit.edu	37	chr19	9058146	9058146	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatccaacacttctgtagtcTtcaccaggcctgggaggata	9	11	3	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr19:9058146T>C	uc002mkp.2	-	3	29504	c.29300A>G	c.(29299-29301)AAG>AGG	p.K9767R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9769	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCTGTAGTCTTCACCAGGCC	0.493													C	9058146	C	C	9058146	3	2	168	1	0	0	0	0	1	0	0	0	9973	1609	56	4	14551	4	MUC16	19	9058146	Missense_Mutation	SNP	T	TCGA-19-5955-01A-11D-1696-08	4240335	9058146	50070837	87	12036											
MUC16	94025	broad.mit.edu	37	chr19	9084687	9084687	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atagttgaagaagctatggaGgtgttgatcagatcagaaga	13	3	2	6			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr19:9084687G>A	uc002mkp.2	-	1	7332	c.7128C>T	c.(7126-7128)ACC>ACT	p.T2376T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2376	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAGCTATGGAGGTGTTGATCA	0.438													A	9084687	A	A	9084687	2	1	168	1	0	0	0	0	0	0	0	1	9973	987	35	3		3	MUC16	19	9084687	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	26541	9084687	50044296	88	12037											
IL28B	282617	broad.mit.edu	37	chr19	39734655	39734655	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgacgactcacacaggccCggagctgggagaggatatgg	15	11	1	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr19:39734655C>T	uc010xut.1	-	3	405	c.401G>A	c.(400-402)CGG>CAG	p.R134Q	IL28B_uc010xuu.1_Missense_Mutation_p.R134Q	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	134					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CACACAGGCCCGGAGCTGGGA	0.667													T	39734655	T	T	39734655	3	4	168	1	0	0	0	0	1	0	0	0	7683	652	23	2	200	2	IL28B	19	39734655	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	30649968	39734655	19394328	89	12038											
KLC3	147700	broad.mit.edu	37	chr19	45853908	45853908	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccctccccaggcccttcgcCgcagcagctcactctccaag	7	22	2	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr19:45853908C>T	uc002pbf.1	+	11	1397	c.1282C>T	c.(1282-1284)CGC>TGC	p.R428C	KLC3_uc010ejy.1_Missense_Mutation_p.R427C|KLC3_uc002pbg.1_Missense_Mutation_p.R442C	NM_177417	NP_803136	Q6P597	KLC3_HUMAN	kinesin light chain 3	428						cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GGCCCTTCGCCGCAGCAGCTC	0.692													T	45853908	T	T	45853908	3	4	168	1	0	0	0	0	1	0	0	0	8335	652	23	2	1320	2	KLC3	19	45853908	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	6119253	45853908	13275075	90	12039											
TMEM143	55260	broad.mit.edu	37	chr19	48845929	48845929	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcatgaggttgagcagggcgCgctgcagggtgggcgtgcgc	21	9	0	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr19:48845929C>T	uc002pix.1	-	6	842	c.833G>A	c.(832-834)CGC>CAC	p.R278H	TMEM143_uc002piw.1_Intron|TMEM143_uc002piy.1_Missense_Mutation_p.R243H|TMEM143_uc010xzn.1_Missense_Mutation_p.R213H|TMEM143_uc010elw.1_Missense_Mutation_p.R178H|TMEM143_uc010xzo.1_Missense_Mutation_p.R68H	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	278						integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		GAGCAGGGCGCGCTGCAGGGT	0.637													T	48845929	T	T	48845929	3	4	168	1	0	0	0	0	1	0	0	0	16054	768	27	1	558	1	TMEM143	19	48845929	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	2992021	48845929	10283054	91	12040											
TMEM150B	284417	broad.mit.edu	37	chr19	55828201	55828201	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagaggcccaggcggaggGgcccaatccaggcagccccg	16	15	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr19:55828201G>A	uc010esw.1	-	7	631	c.458C>T	c.(457-459)CCC>CTC	p.P153L	TMEM150B_uc010yfu.1_Missense_Mutation_p.P153L|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	153	Cytoplasmic (Potential).					integral to membrane					0						CAGGCGGAGGGGCCCAATCCA	0.617													A	55828201	A	A	55828201	3	1	168	1	0	0	0	0	1	0	0	0	16065	1232	43	3	251	3	TMEM150B	19	55828201	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08	6982272	55828201	3300782	92	12041											
SIRPD	128646	broad.mit.edu	37	chr20	1517818	1517818	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctgtgagtcccagcagcCggaggcagcagcagggttgg	16	12	0	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr20:1517818C>T	uc002wfi.2	-	3	604	c.560G>A	c.(559-561)CGG>CAG	p.R187Q		NM_178460	NP_848555	Q9H106	SIRPD_HUMAN	signal-regulatory protein delta precursor	187						extracellular region				ovary(1)|kidney(1)|skin(1)	3						TCCCAGCAGCCGGAGGCAGCA	0.612													T	1517818	T	T	1517818	3	4	168	1	0	0	0	0	1	0	0	0	14335	652	23	2	41	2	SIRPD	20	1517818	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08		1517818	61507702	93	12042											
C20orf132	140699	broad.mit.edu	37	chr20	35776290	35776290	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcagagccactaggtgtccaAgtctttggaatcgcagtgga	12	9	2	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr20:35776290A>C	uc010zvu.1	-	12	1218	c.1127T>G	c.(1126-1128)CTT>CGT	p.L376R	C20orf132_uc002xgk.2_Missense_Mutation_p.L49R|C20orf132_uc002xgm.2_Missense_Mutation_p.L376R|C20orf132_uc002xgn.2_Missense_Mutation_p.L341R	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	251											0		Myeloproliferative disorder(115;0.00878)				TAGGTGTCCAAGTCTTTGGAA	0.478													C	35776290	C	C	35776290	3	2	168	1	0	0	0	0	1	0	0	0	2086	72	3	5	2103	5	C20orf132	20	35776290	Missense_Mutation	SNP	A	TCGA-19-5955-01A-11D-1696-08	34258472	35776290	27249230	94	12043											
PLXNB2	23654	broad.mit.edu	37	chr22	50717405	50717405	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaccttcaccgggatggcGtccactccctcgtcctgcac	10	17	1	0			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chr22:50717405G>A	uc003bkv.3	-	28	4531	c.4425C>T	c.(4423-4425)GAC>GAT	p.D1475D	PLXNB2_uc003bkt.1_Silent_p.D267D|PLXNB2_uc003bku.1_Silent_p.D460D	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1475	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCGGGATGGCGTCCACTCCCT	0.622													A	50717405	A	A	50717405	2	1	168	1	0	0	0	0	0	0	0	1	12124	1136	40	1		1	PLXNB2	22	50717405	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08		50717405	587161	95	12044											
PIM2	11040	broad.mit.edu	37	chrX	48771532	48771532	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtgagggtcgggaagaaGgtttgggggccaggcaccgg	20	8	0	2			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chrX:48771532G>A	uc004dls.2	-	6	1114	c.812C>T	c.(811-813)CCT>CTT	p.P271L	SLC35A2_uc004dlo.1_5'Flank|SLC35A2_uc011mml.1_5'Flank|SLC35A2_uc004dlp.1_5'Flank|SLC35A2_uc011mmm.1_5'Flank|SLC35A2_uc011mmn.1_5'Flank|SLC35A2_uc004dlq.2_5'Flank|SLC35A2_uc011mmo.1_5'Flank	NM_006875	NP_006866	Q9P1W9	PIM2_HUMAN	serine/threonine protein kinase pim-2	271	Protein kinase.				anti-apoptosis|cell proliferation|male meiosis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|response to virus		ATP binding|protein serine/threonine kinase activity			lung(3)|stomach(1)	4						TCGGGAAGAAGGTTTGGGGGC	0.602													A	48771532	A	A	48771532	3	1	168	1	0	0	0	0	1	0	0	0	11928	1000	35	3	127	3	PIM2	23	48771532	Missense_Mutation	SNP	G	TCGA-19-5955-01A-11D-1696-08		48771532	106499028	96	12045											
ATP7A	538	broad.mit.edu	37	chrX	77243835	77243835	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgatgacatgggctttgatgCtgttatccataatcctgacc	9	9	0	4			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chrX:77243835C>A	uc004ecx.3	+	3	378	c.218C>A	c.(217-219)GCT>GAT	p.A73D	ATP7A_uc004ecw.2_Missense_Mutation_p.A73D	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	73	HMA 1.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						GGCTTTGATGCTGTTATCCAT	0.423													A	77243835	A	A	77243835	3	1	168	1	0	0	0	0	1	0	0	0	1190	797	28	5	224	5	ATP7A	23	77243835	Missense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	28472303	77243835	78026725	97	12046											
STAG2	10735	broad.mit.edu	37	chrX	123220476	123220476	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcttccactgatgtcttacCgaaattctttgctagctggt	9	10	2	1			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chrX:123220476C>T	uc004etz.3	+	29	3472	c.3133C>T	c.(3133-3135)CGA>TGA	p.R1045*	STAG2_uc004eua.2_Nonsense_Mutation_p.R1045*|STAG2_uc004eub.2_Nonsense_Mutation_p.R1045*|STAG2_uc004euc.2_Nonsense_Mutation_p.R1045*|STAG2_uc004eud.2_Nonsense_Mutation_p.R1045*|STAG2_uc004eue.2_Nonsense_Mutation_p.R1045*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	1045					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GATGTCTTACCGAAATTCTTT	0.433													T	123220476	T	T	123220476	4	4	168	1	0	0	0	0	0	1	0	0	15242	644	23	2	3243	2	STAG2	23	123220476	Nonsense_Mutation	SNP	C	TCGA-19-5955-01A-11D-1696-08	45976641	123220476	32050084	98	12047											
L1CAM	3897	broad.mit.edu	37	chrX	153129351	153129351	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggctacctgagtatttgccGcccttgctgcgcttgatgaa	11	11	0	3			TCGA-19-5955-01A-11D-1696-08	TCGA-19-5955-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8abde95-f4d7-4d48-879b-bd584eaf8a25	cef2a217-c85e-4fb2-a319-d7a9a02417d4	g.chrX:153129351G>A	uc004fjb.2	-	25	3552	c.3444C>T	c.(3442-3444)GGC>GGT	p.G1148G	L1CAM_uc004fjc.2_Silent_p.G1148G|L1CAM_uc010nuo.2_Silent_p.G1143G	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	1148	Cytoplasmic (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTATTTGCCGCCCTTGCTGC	0.627													A	153129351	A	A	153129351	2	1	168	1	0	0	0	0	0	0	0	1	8588	1074	38	1		1	L1CAM	23	153129351	Silent	SNP	G	TCGA-19-5955-01A-11D-1696-08	29908875	153129351	2141209	99	12048											
ZNF642	339559	broad.mit.edu	37	chr1	40960711	40960711	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgatataatttattccacGttgagaaaagtctccacata	6	7	1	2			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr1:40960711G>A	uc001cfo.2	+	6	855	c.561G>A	c.(559-561)ACG>ACA	p.T187T	ZNF642_uc009vwb.2_Silent_p.T187T|ZNF642_uc010ojk.1_Silent_p.T188T	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)			TTTATTCCACGTTGAGAAAAG	0.398													A	40960711	A	A	40960711	2	1	169	1	0	0	0	0	0	0	0	1	18055	1132	40	1		1	ZNF642	1	40960711	Silent	SNP	G	TCGA-19-5958-01A-11D-1696-08		40960711	208289910	1	12049											
LRPPRC	10128	broad.mit.edu	37	chr2	44152273	44152273	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aatagcttctgtgtcagctcCactaatttttccagagtttc	6	10	2	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr2:44152273C>A	uc002rtr.2	-	27	2887	c.2829G>T	c.(2827-2829)GTG>GTT	p.V943V	LRPPRC_uc010yob.1_Silent_p.V843V	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	943					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTGTCAGCTCCACTAATTTTT	0.323													A	44152273	A	A	44152273	2	1	169	1	0	0	0	0	0	0	0	1	8965	581	21	5		5	LRPPRC	2	44152273	Silent	SNP	C	TCGA-19-5958-01A-11D-1696-08		44152273	199047100	2	12050											
RAB11FIP5	26056	broad.mit.edu	37	chr2	73315641	73315641	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaaccgggaagagacagcttGcaaggagccagaggatggaa	16	7	0	2			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr2:73315641G>C	uc002siu.3	-	3	1346	c.1105C>G	c.(1105-1107)CAA>GAA	p.Q369E	RAB11FIP5_uc002sit.3_Missense_Mutation_p.Q291E	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	369					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GAGACAGCTTGCAAGGAGCCA	0.617													C	73315641	C	C	73315641	3	2	169	1	0	0	0	0	1	0	0	0	12897	1328	46	5	868	5	RAB11FIP5	2	73315641	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08	29163368	73315641	169883732	3	12051											
DNAH6	1768	broad.mit.edu	37	chr2	84777113	84777113	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctcactgacaagctaaaaCgaacaccttcagcagatgtc	6	12	2	2	rs143013494		TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr2:84777113C>T	uc010fgb.2	+	9	1554	c.1417C>T	c.(1417-1419)CGA>TGA	p.R473*	DNAH6_uc002soo.2_Nonsense_Mutation_p.R52*|DNAH6_uc002sop.2_Nonsense_Mutation_p.R52*	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	473	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1						CAAGCTAAAACGAACACCTTC	0.348													T	84777113	T	T	84777113	4	4	169	1	0	0	0	0	0	1	0	0	4605	528	19	1	1447	1	DNAH6	2	84777113	Nonsense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	11461472	84777113	158422260	4	12052											
YSK4	80122	broad.mit.edu	37	chr2	135738725	135738725	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctttattattccagttgGcatgagcataacattatttc	6	8	0	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr2:135738725G>A	uc002tue.1	-	9	3617	c.3586C>T	c.(3586-3588)CCA>TCA	p.P1196S	YSK4_uc002tuf.1_Missense_Mutation_p.P378S|YSK4_uc010fnc.1_Missense_Mutation_p.P330S|YSK4_uc010fnd.1_Missense_Mutation_p.P1083S|YSK4_uc010zbg.1_Missense_Mutation_p.P328S|YSK4_uc002tuh.3_Missense_Mutation_p.P924S|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1196	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		ATTCCAGTTGGCATGAGCATA	0.428													A	135738725	A	A	135738725	3	1	169	1	0	0	0	0	1	0	0	0	17492	1203	42	3	408	3	YSK4	2	135738725	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08	50961612	135738725	107460648	5	12053											
TTN	7273	broad.mit.edu	37	chr2	179605482	179605482	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aataccttctttggagaaggTtttctgggactgtacaatct	9	7	3	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr2:179605482T>A	uc010zfh.1	-	46	12189	c.11965A>T	c.(11965-11967)ACC>TCC	p.T3989S	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.T3922S|TTN_uc010zfj.1_Missense_Mutation_p.T3797S|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGAGAAGGTTTTCTGGGAC	0.453													A	179605482	A	A	179605482	3	1	169	1	0	0	0	0	1	0	0	0	16732	1725	60	5	92311	5	TTN	2	179605482	Missense_Mutation	SNP	T	TCGA-19-5958-01A-11D-1696-08	43866757	179605482	63593891	6	12054											
CACNA1D	776	broad.mit.edu	37	chr3	53757913	53757913	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctttttctcttcattatcAtcttttccttgcttgggatg	6	9	4	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr3:53757913A>G	uc003dgv.3	+	14	2150	c.1987A>G	c.(1987-1989)ATC>GTC	p.I663V	CACNA1D_uc003dgu.3_Missense_Mutation_p.I683V|CACNA1D_uc003dgy.3_Missense_Mutation_p.I663V|CACNA1D_uc003dgw.3_Missense_Mutation_p.I330V	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	663	Helical; Name=S5 of repeat II; (Potential).|II.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CTTCATTATCATCTTTTCCTT	0.438													G	53757913	G	G	53757913	3	3	169	1	0	0	0	0	1	0	0	0	2541	217	8	4	2213	4	CACNA1D	3	53757913	Missense_Mutation	SNP	A	TCGA-19-5958-01A-11D-1696-08		53757913	144264517	7	12055											
CNOT6L	246175	broad.mit.edu	37	chr4	78650009	78650009	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaatgatattataaataccTgaatctggcaatgagttaag	8	4	1	3			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr4:78650009T>C	uc011ccd.1	-	10	1382	c.1251A>G	c.(1249-1251)TCA>TCG	p.S417S	CNOT6L_uc003hks.2_Silent_p.S417S|CNOT6L_uc003hkt.1_Silent_p.S260S	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	417					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						TATAAATACCTGAATCTGGCA	0.403													C	78650009	C	C	78650009	2	2	169	1	0	0	0	0	0	0	0	1	3623	1594	55	4		4	CNOT6L	4	78650009	Silent	SNP	T	TCGA-19-5958-01A-11D-1696-08		78650009	112504267	8	12056											
FRAS1	80144	broad.mit.edu	37	chr4	79236756	79236756	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcctccccttagcttgtgacCaatcctgtgacagttgtggc	10	13	0	2			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr4:79236756C>A	uc003hlb.2	+	16	2127	c.1687C>A	c.(1687-1689)CAA>AAA	p.Q563K	FRAS1_uc003hkw.2_Missense_Mutation_p.Q563K|FRAS1_uc003hky.1_Missense_Mutation_p.Q267K|FRAS1_uc003hkz.2_Missense_Mutation_p.Q267K|FRAS1_uc003hla.1_Missense_Mutation_p.Q74K	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	563	FU 4.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						AGCTTGTGACCAATCCTGTGA	0.478													A	79236756	A	A	79236756	3	1	169	1	0	0	0	0	1	0	0	0	6042	595	21	5	1749	5	FRAS1	4	79236756	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	586747	79236756	111917520	9	12057											
HCN1	348980	broad.mit.edu	37	chr5	45303842	45303842	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tccaggttgaaacacctcaaAtctcaacttgctcagcatgg	7	12	3	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr5:45303842A>T	uc003jok.2	-	6	1502	c.1477T>A	c.(1477-1479)TTT>ATT	p.F493I		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	493	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AACACCTCAAATCTCAACTTG	0.413													T	45303842	T	T	45303842	3	4	169	1	0	0	0	0	1	0	0	0	6996	101	4	5	1207	5	HCN1	5	45303842	Missense_Mutation	SNP	A	TCGA-19-5958-01A-11D-1696-08		45303842	135611418	10	12058											
PLK2	10769	broad.mit.edu	37	chr5	57754862	57754862	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgtgaggaataatttttgCggcgtagactttgttatttg	12	4	0	2			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr5:57754862C>T	uc003jrn.2	-	2	455	c.328G>A	c.(328-330)GCA>ACA	p.A110T	PLK2_uc011cql.1_Missense_Mutation_p.A12T	NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	110	Protein kinase.				positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		ATAATTTTTGCGGCGTAGACT	0.423													T	57754862	T	T	57754862	3	4	169	1	0	0	0	0	1	0	0	0	12096	768	27	1	1781	1	PLK2	5	57754862	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	12451020	57754862	123160398	11	12059											
PIK3R1	5295	broad.mit.edu	37	chr5	67589149	67589149	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggaaagggggaaataacaaAttaatcaaaatatttcatcg	8	4	2	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr5:67589149A>T	uc003jva.2	+	10	1697	c.1137A>T	c.(1135-1137)AAA>AAT	p.K379N	PIK3R1_uc003jvb.2_Missense_Mutation_p.K379N|PIK3R1_uc003jvc.2_Missense_Mutation_p.K79N|PIK3R1_uc003jvd.2_Missense_Mutation_p.K109N|PIK3R1_uc003jve.2_Missense_Mutation_p.K58N|PIK3R1_uc011crb.1_Missense_Mutation_p.K49N	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	379	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GAAATAACAAATTAATCAAAA	0.308			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			T	67589149	T	T	67589149	3	4	169	1	0	0	0	0	1	0	0	0	11918	98	4	5	1301	5	PIK3R1	5	67589149	Missense_Mutation	SNP	A	TCGA-19-5958-01A-11D-1696-08	9834287	67589149	113326111	12	12060											
TGFBI	7045	broad.mit.edu	37	chr5	135385160	135385160	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcatcagggctcaacacgatGcttgaaggtaacggccagta	12	10	2	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr5:135385160G>T	uc003lbf.3	+	7	965	c.804G>T	c.(802-804)ATG>ATT	p.M268I	TGFBI_uc003lbg.3_Missense_Mutation_p.M1I|TGFBI_uc003lbh.3_Missense_Mutation_p.M94I|TGFBI_uc011cyb.1_Missense_Mutation_p.M94I|TGFBI_uc010jed.2_Missense_Mutation_p.M1I	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	268	FAS1 2.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCAACACGATGCTTGAAGGTA	0.567													T	135385160	T	T	135385160	3	4	169	1	0	0	0	0	1	0	0	0	15817	1319	46	5	830	5	TGFBI	5	135385160	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08	67796011	135385160	45530100	13	12061											
NDST1	3340	broad.mit.edu	37	chr5	149925000	149925000	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcttgcccaaagccaaggtCctgaccatcctcatcaaccc	5	18	3	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr5:149925000C>T	uc003lsk.3	+	11	2599	c.2097C>T	c.(2095-2097)GTC>GTT	p.V699V	NDST1_uc011dcj.1_Silent_p.V699V	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	699	Heparan sulfate N-sulfotransferase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGCCAAGGTCCTGACCATCC	0.612													T	149925000	T	T	149925000	2	4	169	1	0	0	0	0	0	0	0	1	10255	842	30	3		3	NDST1	5	149925000	Silent	SNP	C	TCGA-19-5958-01A-11D-1696-08	14539840	149925000	30990260	14	12062											
ANXA6	309	broad.mit.edu	37	chr5	150512089	150512089	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacagctcccctcggatgctGgcttcaatcggcttccctgt	10	15	1	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr5:150512089G>A	uc003ltl.1	-	10	836	c.684C>T	c.(682-684)GCC>GCT	p.A228A	ANXA6_uc011dcp.1_Silent_p.A196A|ANXA6_uc003ltm.1_Silent_p.A228A|ANXA6_uc003ltn.1_Intron|ANXA6_uc003lto.1_Intron	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	228	Annexin 3.					melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCGGATGCTGGCTTCAATCG	0.542													A	150512089	A	A	150512089	2	1	169	1	0	0	0	0	0	0	0	1	722	1335	47	3		3	ANXA6	5	150512089	Silent	SNP	G	TCGA-19-5958-01A-11D-1696-08	587089	150512089	30403171	15	12063											
DOCK2	1794	broad.mit.edu	37	chr5	169098173	169098174	+	Frame_Shift_Del	DEL	TA	-	-													gaagcatctggaaacaactcTatgtggtgagactcagaact							TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr5:169098173_169098174delTA	uc003maf.2	+	5	396_397	c.316_317delTA	c.(316-318)TATfs	p.Y106fs	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	106					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAAACAACTCTATGTGGTGAGA	0.441													-	169098174	-	-	169098173	7	5	169	1	0	1	0	1	0	0	0	0	4687	1522	53	0	334	0	DOCK2	5	169098173	Frame_Shift_Del	DEL	TA	TCGA-19-5958-01A-11D-1696-08	18586084	169098173	11817087	16	12064											
PRSS16	10279	broad.mit.edu	37	chr6	27222902	27222902	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	actcccccagcctccgcctaGggcgccaggtaagagaaaaa	10	15	0	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr6:27222902G>T	uc003nja.2	+	11	1480	c.1468G>T	c.(1468-1470)GGG>TGG	p.G490W	PRSS16_uc011dkt.1_RNA|PRSS16_uc003njb.2_Missense_Mutation_p.G233W|PRSS16_uc003njd.2_RNA	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	490					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						CCTCCGCCTAGGGCGCCAGGT	0.507													T	27222902	T	T	27222902	3	4	169	1	0	0	0	0	1	0	0	0	12616	1000	35	5	1510	5	PRSS16	6	27222902	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08		27222902	143892165	17	12065											
MSH5	4439	broad.mit.edu	37	chr6	31721395	31721395	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccaaggtcagcgactggcagGttctctacaaggtaaggcct	12	11	2	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr6:31721395G>T	uc003nwv.1	+	12	1082	c.1003G>T	c.(1003-1005)GTT>TTT	p.V335F	MSH5_uc003nwt.1_Missense_Mutation_p.V352F|MSH5_uc003nwu.1_Missense_Mutation_p.V335F|MSH5_uc003nww.1_Missense_Mutation_p.V335F|MSH5_uc003nwx.1_Missense_Mutation_p.V352F|MSH5_uc011dof.1_Missense_Mutation_p.V34F|MSH5_uc003nwy.1_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	335					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						CGACTGGCAGGTTCTCTACAA	0.493								Direct_reversal_of_damage|MMR					T	31721395	T	T	31721395	3	4	169	1	0	0	0	0	1	0	0	0	9873	1261	44	5	1096	5	MSH5	6	31721395	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08	4498493	31721395	139393672	18	12066											
ANKRD6	22881	broad.mit.edu	37	chr6	90333750	90333750	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcagctctacacattgtacCggggcaaggatgggaaagtg	13	8	2	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr6:90333750C>T	uc003pni.3	+	12	1533	c.1192C>T	c.(1192-1194)CGG>TGG	p.R398W	ANKRD6_uc003pne.3_Missense_Mutation_p.R398W|ANKRD6_uc003pnf.3_Missense_Mutation_p.R363W|ANKRD6_uc011dzy.1_Missense_Mutation_p.R398W|ANKRD6_uc010kcd.2_Missense_Mutation_p.R339W|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_5'UTR|LYRM2_uc010kcf.1_Intron|ANKRD6_uc003pnj.3_5'UTR	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	398							protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		CACATTGTACCGGGGCAAGGA	0.522													T	90333750	T	T	90333750	3	4	169	1	0	0	0	0	1	0	0	0	685	643	23	2	1234	2	ANKRD6	6	90333750	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	58612355	90333750	80781317	19	12067											
SLC22A3	6581	broad.mit.edu	37	chr6	160819102	160819102	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggagcattcaccttaggctAtgcagcagacaggtaggtac	12	9	1	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr6:160819102A>G	uc003qti.2	+	2	548	c.521A>G	c.(520-522)TAT>TGT	p.Y174C	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	174						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		ACCTTAGGCTATGCAGCAGAC	0.433													G	160819102	G	G	160819102	3	3	169	1	0	0	0	0	1	0	0	0	14455	449	16	4	527	4	SLC22A3	6	160819102	Missense_Mutation	SNP	A	TCGA-19-5958-01A-11D-1696-08	70485352	160819102	10295965	20	12068											
ABCB1	5243	broad.mit.edu	37	chr7	87135283	87135283	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgaggctgtctaacaaggGcacgagctatggcaatgcgt	13	8	1	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr7:87135283G>A	uc003uiz.1	-	28	3984	c.3566C>T	c.(3565-3567)GCC>GTC	p.A1189V	ABCB1_uc011khc.1_Missense_Mutation_p.A1125V	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	1189	Cytoplasmic (Potential).|ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCTAACAAGGGCACGAGCTAT	0.403													A	87135283	A	A	87135283	3	1	169	1	0	0	0	0	1	0	0	0	40	1203	42	3	284	3	ABCB1	7	87135283	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08		87135283	72003380	21	12069											
MLL3	58508	broad.mit.edu	37	chr7	151970848	151970848	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aggaagatgtgactgaaatcCtgaaaggtgccggctcctgc	13	9	0	4			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr7:151970848C>A	uc003wla.2	-	7	1173	c.954G>T	c.(952-954)CAG>CAT	p.Q318H		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	318					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GACTGAAATCCTGAAAGGTGC	0.423			N		medulloblastoma								A	151970848	A	A	151970848	3	1	169	1	0	0	0	0	1	0	0	0	9622	680	24	5	13993	5	MLL3	7	151970848	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	64835565	151970848	7167815	22	12070											
SAMD12	401474	broad.mit.edu	37	chr8	119593041	119593041	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tttttatttttaatggattgAgattccacaccttcaccttc	4	9	1	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr8:119593041A>T	uc003yom.2	-	2	234	c.105T>A	c.(103-105)TCT>TCA	p.S35S	SAMD12_uc010mda.1_Silent_p.S35S|SAMD12_uc010mdb.1_RNA	NM_207506	NP_997389	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12 isoform	35										ovary(1)	1	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)			TAATGGATTGAGATTCCACAC	0.453													T	119593041	T	T	119593041	2	4	169	1	0	0	0	0	0	0	0	1	13817	291	11	5		5	SAMD12	8	119593041	Silent	SNP	A	TCGA-19-5958-01A-11D-1696-08		119593041	26770981	23	12071											
TBC1D2	55357	broad.mit.edu	37	chr9	100971301	100971301	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagcgctccctcagcggcCgatccacagcctcgaggccc	10	21	1	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr9:100971301C>T	uc011lvb.1	-	9	1979	c.1799G>A	c.(1798-1800)CGG>CAG	p.R600Q	TBC1D2_uc004ayp.2_Missense_Mutation_p.R140Q|TBC1D2_uc004ayq.2_Missense_Mutation_p.R600Q|TBC1D2_uc004ayr.2_Missense_Mutation_p.R382Q|TBC1D2_uc004ayo.3_Missense_Mutation_p.R600Q	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	600						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CCTCAGCGGCCGATCCACAGC	0.652													T	100971301	T	T	100971301	3	4	169	1	0	0	0	0	1	0	0	0	15605	652	23	2	974	2	TBC1D2	9	100971301	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08		100971301	40242130	24	12072											
PRKG1	5592	broad.mit.edu	37	chr10	54053584	54053584	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcatcacccacagacacaaGtaattttgacagtttccctg	6	12	1	2			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr10:54053584G>A	uc001jjm.2	+	18	2134	c.1940G>A	c.(1939-1941)AGT>AAT	p.S647N	PRKG1_uc001jjo.2_Missense_Mutation_p.S662N|PRKG1_uc009xow.1_Missense_Mutation_p.S365N|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	647	AGC-kinase C-terminal.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity	p.L647L(1)		lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		ACAGACACAAGTAATTTTGAC	0.388													A	54053584	A	A	54053584	3	1	169	1	0	0	0	0	1	0	0	0	12522	1029	36	3	2325	3	PRKG1	10	54053584	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08		54053584	81481163	25	12073											
RRP12	23223	broad.mit.edu	37	chr10	99130292	99130292	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgttcttccgtgcgcccaccGacacctccttggtgcacagg	10	17	1	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr10:99130292G>A	uc001knf.2	-	23	2748	c.2609C>T	c.(2608-2610)TCG>TTG	p.S870L	RRP12_uc009xvl.2_5'UTR|RRP12_uc009xvm.2_Missense_Mutation_p.S588L|RRP12_uc010qou.1_Missense_Mutation_p.S809L|RRP12_uc009xvn.2_Missense_Mutation_p.S770L	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	870						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TGCGCCCACCGACACCTCCTT	0.612													A	99130292	A	A	99130292	3	1	169	1	0	0	0	0	1	0	0	0	13686	1059	37	2	1332	2	RRP12	10	99130292	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08	45076708	99130292	36404455	26	12074											
RIC8A	60626	broad.mit.edu	37	chr11	209871	209871	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgacacactggagctgacGctgggggtgactcctgaagg	15	10	0	4			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr11:209871G>A	uc001log.2	+	3	922	c.597G>A	c.(595-597)ACG>ACA	p.T199T	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Silent_p.T199T|RIC8A_uc001loh.2_Silent_p.T192T	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	199						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		TGGAGCTGACGCTGGGGGTGA	0.602													A	209871	A	A	209871	2	1	169	1	0	0	0	0	0	0	0	1	13355	1074	38	1		1	RIC8A	11	209871	Silent	SNP	G	TCGA-19-5958-01A-11D-1696-08		209871	134796645	27	12075											
OR52A4	390053	broad.mit.edu	37	chr11	5142008	5142008	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatataagatccaaatctgCgagtaaaaaatgaaaaaaaa	7	4	1	2			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr11:5142008C>T	uc001lzz.1	-	1	801	c.801G>A	c.(799-801)TCG>TCA	p.S267S		NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TCCAAATCTGCGAGTAAAAAA	0.368													T	5142008	T	T	5142008	2	4	169	1	0	0	0	0	0	0	0	1	11109	755	27	1		1	OR52A4	11	5142008	Silent	SNP	C	TCGA-19-5958-01A-11D-1696-08	4932137	5142008	129864508	28	12076											
MMP3	4314	broad.mit.edu	37	chr11	102709358	102709358	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctgcatcgattttcctcaCggttggagggaaacctaggg	14	9	1	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr11:102709358C>T	uc001phj.1	-	8	1218	c.1153G>A	c.(1153-1155)GTG>ATG	p.V385M		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	385					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	ATTTTCCTCACGGTTGGAGGG	0.403													T	102709358	T	T	102709358	3	4	169	1	0	0	0	0	1	0	0	0	9666	536	19	1	292	1	MMP3	11	102709358	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	97567350	102709358	32297158	29	12077											
SCN2B	6327	broad.mit.edu	37	chr11	118037799	118037799	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgtggagtcccgctcaggggGctctggaaaggaagcagagc	17	10	2	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr11:118037799G>T	uc001psf.2	-	4	642	c.451C>A	c.(451-453)CCC>ACC	p.P151T		NM_004588	NP_004579	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta	151	Ig-like C2-type.|Extracellular (Potential).				synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity				0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		CGCTCAGGGGGCTCTGGAAAG	0.627													T	118037799	T	T	118037799	3	4	169	1	0	0	0	0	1	0	0	0	13917	1203	42	5	200	5	SCN2B	11	118037799	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08	15328441	118037799	16968717	30	12078											
PIWIL1	9271	broad.mit.edu	37	chr12	130833883	130833883	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaagtccttcgaagtgagacTgttttggatttcatgttcaa	9	6	2	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr12:130833883T>A	uc001uik.2	+	8	924	c.834T>A	c.(832-834)ACT>ACA	p.T278T	PIWIL1_uc001uij.1_Silent_p.T278T	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	278	PAZ.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GAAGTGAGACTGTTTTGGATT	0.383													A	130833883	A	A	130833883	2	1	169	1	0	0	0	0	0	0	0	1	11957	1567	55	5		5	PIWIL1	12	130833883	Silent	SNP	T	TCGA-19-5958-01A-11D-1696-08		130833883	3018012	31	12079											
IRS2	8660	broad.mit.edu	37	chr13	110436118	110436118	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaggtagtccccgttgggCagcagcttgccatctgcatg	13	11	1	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr13:110436118C>T	uc001vqv.2	-	1	2797	c.2283G>A	c.(2281-2283)CTG>CTA	p.L761L		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	761					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			CCCCGTTGGGCAGCAGCTTGC	0.692													T	110436118	T	T	110436118	2	4	169	1	0	0	0	0	0	0	0	1	7841	697	25	3		3	IRS2	13	110436118	Silent	SNP	C	TCGA-19-5958-01A-11D-1696-08		110436118	4733760	32	12080											
NFATC4	4776	broad.mit.edu	37	chr14	24845826	24845826	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctagtgacccgtatggagggCggggctcctctttctccctg	13	13	2	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr14:24845826C>T	uc001wpc.2	+	9	2704	c.2383C>T	c.(2383-2385)CGG>TGG	p.R795W	NFATC4_uc010tok.1_Missense_Mutation_p.R858W|NFATC4_uc010tol.1_Missense_Mutation_p.R858W|NFATC4_uc010alr.2_Intron|NFATC4_uc010tom.1_Missense_Mutation_p.R808W|NFATC4_uc010ton.1_Missense_Mutation_p.R808W|NFATC4_uc010too.1_Intron|NFATC4_uc010alt.2_Missense_Mutation_p.R827W|NFATC4_uc010top.1_Missense_Mutation_p.R827W|NFATC4_uc010toq.1_Intron|NFATC4_uc010tor.1_Intron|NFATC4_uc010tos.1_Missense_Mutation_p.R725W|NFATC4_uc010tot.1_Missense_Mutation_p.R783W|NFATC4_uc010tou.1_Missense_Mutation_p.R725W|NFATC4_uc010tov.1_Intron|NFATC4_uc010tow.1_Intron|NFATC4_uc010alv.2_Missense_Mutation_p.R783W|NFATC4_uc010tox.1_Missense_Mutation_p.R725W|NFATC4_uc001wpd.2_Missense_Mutation_p.R330W|NFATC4_uc010toy.1_Intron|NFATC4_uc010toz.1_Missense_Mutation_p.R330W|NFATC4_uc010tpa.1_Missense_Mutation_p.R83W|NFATC4_uc010tpb.1_Missense_Mutation_p.R83W	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	795	Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		GTATGGAGGGCGGGGCTCCTC	0.642													T	24845826	T	T	24845826	3	4	169	1	0	0	0	0	1	0	0	0	10365	759	27	1	2610	1	NFATC4	14	24845826	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08		24845826	82503714	33	12081											
C14orf105	55195	broad.mit.edu	37	chr14	57949812	57949812	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcattgtcctggcttctcGctggctcaggagtcttcctg	12	12	3	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr14:57949812G>A	uc001xcy.2	-	3	507	c.364C>T	c.(364-366)CGA>TGA	p.R122*	C14orf105_uc010trl.1_Nonsense_Mutation_p.R122*|C14orf105_uc010trm.1_Nonsense_Mutation_p.R34*|C14orf105_uc010trn.1_Nonsense_Mutation_p.R34*|C14orf105_uc001xcz.2_Nonsense_Mutation_p.R122*|C14orf105_uc010aox.1_RNA|C14orf105_uc010aoy.1_Nonsense_Mutation_p.R44*	NM_018168	NP_060638	Q9NVL8	CN105_HUMAN	hypothetical protein LOC55195	122											0						CTGGCTTCTCGCTGGCTCAGG	0.522													A	57949812	A	A	57949812	4	1	169	1	0	0	0	0	0	1	0	0	1737	1095	38	1	542	1	C14orf105	14	57949812	Nonsense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08	33103986	57949812	49399728	34	12082											
ATP10A	57194	broad.mit.edu	37	chr15	25924506	25924506	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tttcactgtgaccgccttgaAgatgctcctataagtagtct	8	10	2	3			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr15:25924506A>T	uc010ayu.2	-	21	4588	c.4482T>A	c.(4480-4482)TCT>TCA	p.S1494S		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1494	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		ACCGCCTTGAAGATGCTCCTA	0.408													T	25924506	T	T	25924506	2	4	169	1	0	0	0	0	0	0	0	1	1116	59	3	5		5	ATP10A	15	25924506	Silent	SNP	A	TCGA-19-5958-01A-11D-1696-08		25924506	76606886	35	12083											
CACNA1H	8912	broad.mit.edu	37	chr16	1259347	1259347	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggtggtggccctgcccagcGacttcttcctgcgcatcgac	12	15	1	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr16:1259347G>A	uc002cks.2	+	17	3927	c.3679G>A	c.(3679-3681)GAC>AAC	p.D1227N	CACNA1H_uc002ckt.2_Missense_Mutation_p.D1227N|CACNA1H_uc002cku.2_5'Flank|CACNA1H_uc010brj.2_5'Flank|CACNA1H_uc002ckv.2_5'Flank	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1227	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CCTGCCCAGCGACTTCTTCCT	0.736													A	1259347	A	A	1259347	3	1	169	1	0	0	0	0	1	0	0	0	2545	1058	37	2	3741	2	CACNA1H	16	1259347	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08		1259347	89095406	36	12084											
CORO7	79585	broad.mit.edu	37	chr16	4409376	4409376	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagctcgtacaggaatacaCgggtgtcgccctgcggggaa	15	11	0	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr16:4409376C>T	uc002cwh.3	-	23	2381	c.2261G>A	c.(2260-2262)CGT>CAT	p.R754H	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.R754H|CORO7_uc002cwg.3_Missense_Mutation_p.R534H|CORO7_uc010uxh.1_Missense_Mutation_p.R736H|CORO7_uc010uxi.1_Missense_Mutation_p.R669H|CORO7_uc002cwi.1_Missense_Mutation_p.R534H	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	754	WD 8.					cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						CAGGAATACACGGGTGTCGCC	0.667											OREG0023580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	4409376	T	T	4409376	3	4	169	1	0	0	0	0	1	0	0	0	3759	536	19	1	540	1	CORO7	16	4409376	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	3150029	4409376	85945377	37	12085											
MGRN1	23295	broad.mit.edu	37	chr16	4731589	4731589	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggctacgagcccatctcGctgctcgaggcgctcaacgg	12	16	2	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr16:4731589G>A	uc002cwz.2	+	13	1306	c.1170G>A	c.(1168-1170)TCG>TCA	p.S390S	MGRN1_uc002cxa.2_Silent_p.S390S|MGRN1_uc010btx.2_Silent_p.S369S|MGRN1_uc010btw.2_Silent_p.S369S|MGRN1_uc002cxb.2_Silent_p.S429S|MGRN1_uc010uxo.1_Silent_p.S368S|MGRN1_uc010uxp.1_Silent_p.S368S|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	390					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						AGCCCATCTCGCTGCTCGAGG	0.647													A	4731589	A	A	4731589	2	1	169	1	0	0	0	0	0	0	0	1	9559	1074	38	1		1	MGRN1	16	4731589	Silent	SNP	G	TCGA-19-5958-01A-11D-1696-08	322213	4731589	85623164	38	12086											
NKD1	85407	broad.mit.edu	37	chr16	50664787	50664787	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaagcccactgaggacctgCggagctgggagaagaagcag	15	11	0	3			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr16:50664787C>T	uc002egg.1	+	8	885	c.661C>T	c.(661-663)CGG>TGG	p.R221W		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	221					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		TGAGGACCTGCGGAGCTGGGA	0.612													T	50664787	T	T	50664787	3	4	169	1	0	0	0	0	1	0	0	0	10441	759	27	1	691	1	NKD1	16	50664787	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	45933198	50664787	39689966	39	12087											
CNGB1	1258	broad.mit.edu	37	chr16	57949167	57949167	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctacctttaaacagcgggGcaggcggaggagggggttca	16	9	1	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr16:57949167G>A	uc002emt.2	-	23	2355	c.2290C>T	c.(2290-2292)CCC>TCC	p.P764S	CNGB1_uc010cdh.2_Missense_Mutation_p.P758S	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	764	Extracellular (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						AAACAGCGGGGCAGGCGGAGG	0.602													A	57949167	A	A	57949167	3	1	169	1	0	0	0	0	1	0	0	0	3600	1203	42	3	1509	3	CNGB1	16	57949167	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08	7284380	57949167	32405586	40	12088											
MYH4	4622	broad.mit.edu	37	chr17	10355578	10355578	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcccgggagaggtcagagcGctgcttctctgctttggccc	13	14	2	2			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr17:10355578G>A	uc002gmn.2	-	27	3529	c.3418C>T	c.(3418-3420)CGC>TGC	p.R1140C	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1140	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						AGGTCAGAGCGCTGCTTCTCT	0.582													A	10355578	A	A	10355578	3	1	169	1	0	0	0	0	1	0	0	0	10037	1087	38	1	2457	1	MYH4	17	10355578	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08		10355578	70839632	41	12089											
DNAH9	1770	broad.mit.edu	37	chr17	11572540	11572540	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggataccatctctggtgcCacggctttccccacaaaatg	8	13	1	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr17:11572540C>T	uc002gne.2	+	16	2959	c.2891C>T	c.(2890-2892)CCA>CTA	p.P964L	DNAH9_uc010coo.2_Missense_Mutation_p.P258L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	964	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCTCTGGTGCCACGGCTTTCC	0.527													T	11572540	T	T	11572540	3	4	169	1	0	0	0	0	1	0	0	0	4608	594	21	3	2953	3	DNAH9	17	11572540	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	1216962	11572540	69622670	42	12090											
ERAL1	26284	broad.mit.edu	37	chr17	27182172	27182172	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcctcactcttaggcttccaAcggaggtgcgtgtcctgcgt	11	13	2	0			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr17:27182172A>G	uc002hcy.1	+	1	130	c.120A>G	c.(118-120)CAA>CAG	p.Q40Q	ERAL1_uc002hcx.1_Silent_p.Q40Q|ERAL1_uc002hcz.1_RNA|ERAL1_uc002hda.1_5'Flank|ERAL1_uc002hdb.1_5'Flank	NM_005702	NP_005693	O75616	ERAL1_HUMAN	Era-like 1	40					ribosomal small subunit assembly	mitochondrial inner membrane|mitochondrial matrix	GTP binding|ribosomal small subunit binding|rRNA binding			skin(1)	1	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.12e-05)|all cancers(11;5.32e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.105)			TAGGCTTCCAACGGAGGTGCG	0.627													G	27182172	G	G	27182172	2	3	169	1	0	0	0	0	0	0	0	1	5202	40	2	4		4	ERAL1	17	27182172	Silent	SNP	A	TCGA-19-5958-01A-11D-1696-08	15609632	27182172	54013038	43	12091											
ICAM4	3386	broad.mit.edu	37	chr19	10398453	10398453	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcccgtgatctgccacgcGcgcctcaatctcgacggcct	10	18	3	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr19:10398453G>A	uc002mns.1	+	2	675	c.636G>A	c.(634-636)GCG>GCA	p.A212A	ICAM4_uc002mnr.1_Missense_Mutation_p.A187T|ICAM4_uc002mnt.1_Silent_p.A212A|ICAM5_uc002mnu.3_5'Flank	NM_001544	NP_001535	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 isoform 1	212	Ig-like C2-type 2.|Extracellular (Potential).				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			TCTGCCACGCGCGCCTCAATC	0.642													A	10398453	A	A	10398453	2	1	169	1	0	0	0	0	0	0	0	1	7482	1087	38	1		1	ICAM4	19	10398453	Silent	SNP	G	TCGA-19-5958-01A-11D-1696-08		10398453	48730530	44	12092											
OR10H1	26539	broad.mit.edu	37	chr19	15918076	15918076	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgggcttcaggtaaatgaCggaggcaaagccatagtgca	13	7	1	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr19:15918076C>T	uc002nbq.2	-	1	861	c.772G>A	c.(772-774)GTC>ATC	p.V258I		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	258	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGTAAATGACGGAGGCAAAG	0.552													T	15918076	T	T	15918076	3	4	169	1	0	0	0	0	1	0	0	0	10905	536	19	1	188	1	OR10H1	19	15918076	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	5519623	15918076	43210907	45	12093											
PSG9	5678	broad.mit.edu	37	chr19	43766196	43766196	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccaccataggtagcttgcGtccagagtctcaggatcaca	9	12	2	1	rs150952802		TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr19:43766196G>A	uc002owd.3	-	3	624	c.525C>T	c.(523-525)GAC>GAT	p.D175D	PSG9_uc002owe.3_Silent_p.D175D|PSG9_uc010xwm.1_Intron|PSG9_uc002owf.3_Intron|PSG9_uc002owg.2_Silent_p.D175D|PSG9_uc002owh.2_Intron	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	175	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				GGTAGCTTGCGTCCAGAGTCT	0.532													A	43766196	A	A	43766196	2	1	169	1	0	0	0	0	0	0	0	1	12662	1136	40	1		1	PSG9	19	43766196	Silent	SNP	G	TCGA-19-5958-01A-11D-1696-08	27848120	43766196	15362787	46	12094											
PLEKHA4	57664	broad.mit.edu	37	chr19	49360714	49360714	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcccgggtcccagggggccGcggggggagctggagataag	22	10	0	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr19:49360714G>A	uc002pkx.2	-	9	1563	c.1012C>T	c.(1012-1014)CGG>TGG	p.R338W	PLEKHA4_uc002pkw.1_Intron|PLEKHA4_uc010eml.2_Intron	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	338	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		CCAGGGGGCCGCGGGGGGAGC	0.512													A	49360714	A	A	49360714	3	1	169	1	0	0	0	0	1	0	0	0	12058	1086	38	1	1375	1	PLEKHA4	19	49360714	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08	5594518	49360714	9768269	47	12095											
GFRA4	64096	broad.mit.edu	37	chr20	3640606	3640606	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagtatggagagcagggagcGtctctccagggccctgcctg	15	11	1	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr20:3640606G>A	uc002wio.2	-	5	850	c.850C>T	c.(850-852)CGC>TGC	p.R284C	GFRA4_uc002win.2_Missense_Mutation_p.R254C	NM_145762	NP_665705	Q9GZZ7	GFRA4_HUMAN	GDNF family receptor alpha 4 isoform b	284						anchored to membrane|extracellular region|plasma membrane	receptor activity				0						AGCAGGGAGCGTCTCTCCAGG	0.642													A	3640606	A	A	3640606	3	1	169	1	0	0	0	0	1	0	0	0	6350	1145	40	1	53	1	GFRA4	20	3640606	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08		3640606	59384914	48	12096											
MX2	4600	broad.mit.edu	37	chr21	42770891	42770891	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgaccgaggagctgcggcGttgcggggctgacatcccca	17	13	0	1			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chr21:42770891G>A	uc002yzf.1	+	9	1321	c.1217G>A	c.(1216-1218)CGT>CAT	p.R406H	MX2_uc011aer.1_RNA|MX2_uc002yzg.1_Missense_Mutation_p.R129H|MX2_uc010gop.1_5'UTR	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	406					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				GAGCTGCGGCGTTGCGGGGCT	0.527													A	42770891	A	A	42770891	3	1	169	1	0	0	0	0	1	0	0	0	9998	1145	40	1	1247	1	MX2	21	42770891	Missense_Mutation	SNP	G	TCGA-19-5958-01A-11D-1696-08		42770891	5359004	49	12097											
ITIH5L	347365	broad.mit.edu	37	chrX	54785074	54785074	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccacccaggtagttcagaCgcacatctgccagcagaggc	11	14	2	2			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chrX:54785074C>T	uc004dtj.2	-	8	1463	c.1433G>A	c.(1432-1434)CGT>CAT	p.R478H		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	478					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GTAGTTCAGACGCACATCTGC	0.597													T	54785074	T	T	54785074	3	4	169	1	0	0	0	0	1	0	0	0	7908	536	19	1	2532	1	ITIH5L	23	54785074	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08		54785074	100485486	50	12098											
TBC1D8B	54885	broad.mit.edu	37	chrX	106109162	106109162	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacttgttgagtccctgggCtcattctgcaaataaagact	8	10	3	2			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chrX:106109162C>T	uc004emo.2	+	16	2726	c.2561C>T	c.(2560-2562)GCT>GTT	p.A854V	MORC4_uc004emp.3_Intron	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	854						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AGTCCCTGGGCTCATTCTGCA	0.408													T	106109162	T	T	106109162	3	4	169	1	0	0	0	0	1	0	0	0	15623	797	28	3	2689	3	TBC1D8B	23	106109162	Missense_Mutation	SNP	C	TCGA-19-5958-01A-11D-1696-08	51324088	106109162	49161398	51	12099											
PCDH11Y	83259	broad.mit.edu	37	chrY	4925190	4925190	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agatgtgccactgattcgaaTtgaagaggatactggtgaga	13	5	0	5			TCGA-19-5958-01A-11D-1696-08	TCGA-19-5958-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	fd385a8e-d6dc-4e65-a023-ce485793c410	eafda2ee-1ee1-4fe4-8ceb-953e687102e9	g.chrY:4925190T>A	uc004fqo.2	+	1	1060	c.326T>A	c.(325-327)ATT>AAT	p.I109N	PCDH11Y_uc010nwg.1_Missense_Mutation_p.I98N|PCDH11Y_uc004fql.1_Missense_Mutation_p.I98N|PCDH11Y_uc004fqm.1_Missense_Mutation_p.I98N|PCDH11Y_uc004fqn.1_Missense_Mutation_p.I109N	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	109	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						CTGATTCGAATTGAAGAGGAT	0.443													A	4925190	A	A	4925190	3	1	169	1	0	0	0	0	1	0	0	0	11509	1493	52	5	364	5	PCDH11Y	24	4925190	Missense_Mutation	SNP	T	TCGA-19-5958-01A-11D-1696-08		4925190	54448376	52	12100											
SKI	6497	broad.mit.edu	37	chr1	2234792	2234792	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggtcccccgcagtgtcagcGagtgagaaagagctctcccc	12	14	2	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:2234792G>A	uc001aja.3	+	3	1236	c.1164G>A	c.(1162-1164)GCG>GCA	p.A388A		NM_003036	NP_003027	P12755	SKI_HUMAN	v-ski sarcoma viral oncogene homolog	388					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		CAGTGTCAGCGAGTGAGAAAG	0.622													A	2234792	A	A	2234792	2	1	170	1	0	0	0	0	0	0	0	1	14357	1045	37	2		2	SKI	1	2234792	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08		2234792	247015829	1	12101											
HIVEP3	59269	broad.mit.edu	37	chr1	42048030	42048030	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttccaagccactcggctgCtcgagagaatcagatttctc	8	14	2	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:42048030C>T	uc001cgz.3	-	4	3652	c.2439G>A	c.(2437-2439)GAG>GAA	p.E813E	HIVEP3_uc001cha.3_Silent_p.E813E|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	813	Ser-rich.|No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CACTCGGCTGCTCGAGAGAAT	0.557													T	42048030	T	T	42048030	2	4	170	1	0	0	0	0	0	0	0	1	7188	796	28	3		3	HIVEP3	1	42048030	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	39813238	42048030	207202591	2	12102											
ZYG11B	79699	broad.mit.edu	37	chr1	53250588	53250588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaccaccctatgaatttgCcagtgcaactggctgcaagc	9	12	0	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:53250588C>T	uc001cuj.2	+	5	1327	c.1132C>T	c.(1132-1134)CCA>TCA	p.P378S	ZYG11B_uc009vzg.2_RNA|ZYG11B_uc010onj.1_Missense_Mutation_p.P369S	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	378							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TATGAATTTGCCAGTGCAACT	0.458													T	53250588	T	T	53250588	3	4	170	1	0	0	0	0	1	0	0	0	18250	739	26	3	1150	3	ZYG11B	1	53250588	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	11202558	53250588	196000033	3	12103											
PCSK9	255738	broad.mit.edu	37	chr1	55527067	55527067	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgcagctcccactgggaGgtggaggaccttggcaccca	15	13	0	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:55527067G>A	uc001cyf.1	+	11	1992	c.1701G>A	c.(1699-1701)GAG>GAA	p.E567E	PCSK9_uc010oom.1_RNA	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	567					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						CCCACTGGGAGGTGGAGGACC	0.642													A	55527067	A	A	55527067	2	1	170	1	0	0	0	0	0	0	0	1	11606	991	35	3		3	PCSK9	1	55527067	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08	2276479	55527067	193723554	4	12104											
TACSTD2	4070	broad.mit.edu	37	chr1	59041860	59041860	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgccccgccgggtacctaCaagctcggttcctttctcaa	8	17	1	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:59041860C>T	uc001cyz.3	-	1	1307	c.969G>A	c.(967-969)TTG>TTA	p.L323L		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	323	Cytoplasmic (Potential).				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					CGGGTACCTACAAGCTCGGTT	0.537													T	59041860	T	T	59041860	2	4	170	1	0	0	0	0	0	0	0	1	15505	477	17	3		3	TACSTD2	1	59041860	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	3514793	59041860	190208761	5	12105											
DDX20	11218	broad.mit.edu	37	chr1	112305594	112305594	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatatgatgatgagaattgCccagaaatgtaatatcaacc	7	6	1	4			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:112305594C>T	uc001ebs.2	+	10	1634	c.1277C>T	c.(1276-1278)GCC>GTC	p.A426V	DDX20_uc010owf.1_Missense_Mutation_p.A188V|DDX20_uc001ebt.2_Missense_Mutation_p.A34V	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	426	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATGAGAATTGCCCAGAAATGT	0.353													T	112305594	T	T	112305594	3	4	170	1	0	0	0	0	1	0	0	0	4348	739	26	3	1315	3	DDX20	1	112305594	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	53263734	112305594	136945027	6	12106											
CRNN	49860	broad.mit.edu	37	chr1	152382359	152382359	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtctgggcctgtcctcccGgtactgtctctcctgcctca	9	17	3	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:152382359G>A	uc001ezx.2	-	3	1273	c.1199C>T	c.(1198-1200)CCG>CTG	p.P400L		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	400					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCCTCCCGGTACTGTCTC	0.612													A	152382359	A	A	152382359	3	1	170	1	0	0	0	0	1	0	0	0	3892	1116	39	2	292	2	CRNN	1	152382359	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	40076765	152382359	96868262	7	12107											
CD1D	912	broad.mit.edu	37	chr1	158153825	158153825	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcccggtttaagaggcaaaCgtaagtctcccctttccctt	7	14	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:158153825C>T	uc001frr.2	+	6	1485	c.986C>T	c.(985-987)ACT>ATT	p.T329I	CD1D_uc009wss.2_Missense_Mutation_p.T236I	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	329	Cytoplasmic (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					AAGAGGCAAACGTAAGTCTCC	0.512													T	158153825	T	T	158153825	3	4	170	1	0	0	0	0	1	0	0	0	2977	550	19	1	1004	1	CD1D	1	158153825	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	5771466	158153825	91096796	8	12108											
SERPINC1	462	broad.mit.edu	37	chr1	173883833	173883833	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatagaaagtggtagcaaagCgggaattggccttggacagt	15	5	0	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:173883833C>T	uc001gjt.2	-	2	385	c.266G>A	c.(265-267)CGC>CAC	p.R89H		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	89			R -> C (in AT3D; type-I).		blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	GGTAGCAAAGCGGGAATTGGC	0.532											OREG0013990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	173883833	T	T	173883833	3	4	170	1	0	0	0	0	1	0	0	0	14109	768	27	1	1152	1	SERPINC1	1	173883833	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	15730008	173883833	75366788	9	12109											
PRG4	10216	broad.mit.edu	37	chr1	186280588	186280588	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaggattctcagtactggcGttttaccaatgatataaaag	8	7	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:186280588G>A	uc001gru.3	+	10	3704	c.3653G>A	c.(3652-3654)CGT>CAT	p.R1218H	PRG4_uc001grt.3_Missense_Mutation_p.R1177H|PRG4_uc009wyl.2_Missense_Mutation_p.R1125H|PRG4_uc009wym.2_Missense_Mutation_p.R1084H|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1218	Hemopexin-like 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CAGTACTGGCGTTTTACCAAT	0.353													A	186280588	A	A	186280588	3	1	170	1	0	0	0	0	1	0	0	0	12481	1145	40	1	3687	1	PRG4	1	186280588	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	12396755	186280588	62970033	10	12110											
LHX9	56956	broad.mit.edu	37	chr1	197889248	197889248	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaagctggccctcgagtcCgagctcacctgctttgccaa	10	14	1	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:197889248C>T	uc001guk.1	+	2	758	c.321C>T	c.(319-321)TCC>TCT	p.S107S	LHX9_uc001gui.1_Silent_p.S98S|LHX9_uc001guj.1_Silent_p.S113S	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	107	LIM zinc-binding 1.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CCCTCGAGTCCGAGCTCACCT	0.557													T	197889248	T	T	197889248	2	4	170	1	0	0	0	0	0	0	0	1	8777	639	23	2		2	LHX9	1	197889248	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	11608660	197889248	51361373	11	12111											
OBSCN	84033	broad.mit.edu	37	chr1	228509734	228509734	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctgcatccgttttgaggcGctcactgaggcccgccaggc	12	14	2	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr1:228509734G>A	uc009xez.1	+	55	15236	c.15192G>A	c.(15190-15192)GCG>GCA	p.A5064A	OBSCN_uc001hsn.2_Silent_p.A5064A	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5064					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GTTTTGAGGCGCTCACTGAGG	0.612													A	228509734	A	A	228509734	2	1	170	1	0	0	0	0	0	0	0	1	10812	1074	38	1		1	OBSCN	1	228509734	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08	30620486	228509734	20740887	12	12112											
CCDC88A	55704	broad.mit.edu	37	chr2	55563820	55563821	+	Frame_Shift_Del	DEL	TC	-	-													gtaaaaaatgtatgaacctgTctctctgaattttctctcag							TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr2:55563820_55563821delTC	uc002ryv.2	-	14	2494_2495	c.1652_1653delGA	c.(1651-1653)AGAfs	p.R551fs	CCDC88A_uc010yoz.1_Frame_Shift_Del_p.R551fs|CCDC88A_uc010ypa.1_Frame_Shift_Del_p.R551fs|CCDC88A_uc010ypb.1_Frame_Shift_Del_p.R453fs|CCDC88A_uc002ryu.2_5'Flank|CCDC88A_uc002ryw.2_5'Flank	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	551	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TATGAACCTGTCTCTCTGAATT	0.262													-	55563821	-	-	55563820	7	5	170	1	0	1	0	1	0	0	0	0	2863	1664	58	0	4038	0	CCDC88A	2	55563820	Frame_Shift_Del	DEL	TC	TCGA-19-5959-01A-11D-1696-08		55563820	187635553	13	12113											
SMYD5	10322	broad.mit.edu	37	chr2	73453009	73453011	+	In_Frame_Del	DEL	GAG	-	-													cctcagaagaggaagaggaaGaggaggaggaggaggaagga							TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr2:73453009_73453011delGAG	uc002siw.2	+	13	1221_1223	c.1192_1194delGAG	c.(1192-1194)GAGdel	p.E403del	SMYD5_uc010yre.1_In_Frame_Del_p.E287del|SMYD5_uc002six.1_RNA	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	403	Glu-rich.						metal ion binding				0						ggaagaggaagaggaggaggagg	0.468													-	73453011	-	-	73453009	7	5	170	1	0	1	0	1	0	0	0	0	14825	943	33	0	1242	0	SMYD5	2	73453009	In_Frame_Del	DEL	GAG	TCGA-19-5959-01A-11D-1696-08	17889189	73453009	169746364	14	12114											
IL18RAP	8807	broad.mit.edu	37	chr2	103040451	103040451	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgacctatctgatgtccaatGgtaccaacaaccttcgaatg	7	12	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr2:103040451G>T	uc002tbx.2	+	4	735	c.251G>T	c.(250-252)TGG>TTG	p.W84L	IL18RAP_uc010fiz.2_Intron	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	84	Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						GATGTCCAATGGTACCAACAA	0.458													T	103040451	T	T	103040451	3	4	170	1	0	0	0	0	1	0	0	0	7648	1357	47	5	257	5	IL18RAP	2	103040451	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	29587442	103040451	140158922	15	12115											
LRP2	4036	broad.mit.edu	37	chr2	170112639	170112639	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaagatggcaagtccaaacGgatgtgtcatctgctctata	9	9	3	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr2:170112639G>A	uc002ues.2	-	19	2960	c.2747C>T	c.(2746-2748)CCG>CTG	p.P916L	LRP2_uc010zdf.1_Missense_Mutation_p.P779L	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	916	LDL-receptor class B 9.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AAGTCCAAACGGATGTGTCAT	0.378													A	170112639	A	A	170112639	3	1	170	1	0	0	0	0	1	0	0	0	8956	1116	39	2	11464	2	LRP2	2	170112639	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	67072188	170112639	73086734	16	12116											
TTN	7273	broad.mit.edu	37	chr2	179442111	179442111	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggtctaatgtcttttcctGccttggaccaacttgatttt	7	9	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr2:179442111G>A	uc010zfg.1	-	273	61471	c.61247C>T	c.(61246-61248)GCA>GTA	p.A20416V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A14111V|TTN_uc010zfi.1_Missense_Mutation_p.A14044V|TTN_uc010zfj.1_Missense_Mutation_p.A13919V|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21343							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTTTTCCTGCCTTGGACCA	0.403													A	179442111	A	A	179442111	3	1	170	1	0	0	0	0	1	0	0	0	16732	1319	46	3	39184	3	TTN	2	179442111	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	9329472	179442111	63757262	17	12117											
MFF	56947	broad.mit.edu	37	chr2	228195421	228195421	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttcagtacgaaatggaatatActgaaggcattagtcagcga	10	6	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr2:228195421A>T	uc002vos.2	+	4	536	c.118A>T	c.(118-120)ACT>TCT	p.T40S	MFF_uc002vot.2_Missense_Mutation_p.T14S|MFF_uc002vou.2_Missense_Mutation_p.T40S|MFF_uc002vov.2_Missense_Mutation_p.T14S|MFF_uc002vow.2_Missense_Mutation_p.T14S|MFF_uc002vox.2_Missense_Mutation_p.T14S|MFF_uc002voy.2_Missense_Mutation_p.T40S|MFF_uc002voz.2_Missense_Mutation_p.T14S	NM_020194	NP_064579	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	40	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane				large_intestine(1)	1						AATGGAATATACTGAAGGCAT	0.458													T	228195421	T	T	228195421	3	4	170	1	0	0	0	0	1	0	0	0	9519	391	14	5	124	5	MFF	2	228195421	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	48753310	228195421	15003952	18	12118											
UGT1A10	54575	broad.mit.edu	37	chr2	234545533	234545533	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttttcttgacttatttttttCgcattgcaggagtttgttta	7	5	1	1	rs145610800		TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr2:234545533C>T	uc002vur.2	+	1	411	c.365C>T	c.(364-366)TCG>TTG	p.S122L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Missense_Mutation_p.S122L	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	122					flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTATTTTTTTCGCATTGCAGG	0.363													T	234545533	T	T	234545533	3	4	170	1	0	0	0	0	1	0	0	0	16942	893	31	2	367	2	UGT1A10	2	234545533	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	6350112	234545533	8653840	19	12119											
NEU4	129807	broad.mit.edu	37	chr2	242755707	242755707	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtccctcgtaccccttcacGgacagtgctcttcgagcggg	12	15	2	0	rs138212045		TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr2:242755707G>A	uc010fzr.2	+	2	112	c.26G>A	c.(25-27)CGG>CAG	p.R9Q	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Missense_Mutation_p.R9Q|NEU4_uc002wcn.1_Missense_Mutation_p.R21Q|NEU4_uc002wco.1_Missense_Mutation_p.R9Q|NEU4_uc002wcp.1_Missense_Mutation_p.R21Q	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	9						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		ACCCCTTCACGGACAGTGCTC	0.692													A	242755707	A	A	242755707	3	1	170	1	0	0	0	0	1	0	0	0	10344	1116	39	2	71	2	NEU4	2	242755707	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	8210174	242755707	443666	20	12120											
FBLN2	2199	broad.mit.edu	37	chr3	13670420	13670420	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagacatcaacgagtgcaCgtcactgtccgagccatgtc	10	13	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr3:13670420C>T	uc011avb.1	+	11	2569	c.2444C>T	c.(2443-2445)ACG>ATG	p.T815M	FBLN2_uc011auz.1_Missense_Mutation_p.T841M|FBLN2_uc011ava.1_Missense_Mutation_p.T862M|FBLN2_uc011avc.1_Missense_Mutation_p.T862M	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	815	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AACGAGTGCACGTCACTGTCC	0.662													T	13670420	T	T	13670420	3	4	170	1	0	0	0	0	1	0	0	0	5699	536	19	1	1317	1	FBLN2	3	13670420	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08		13670420	184352010	21	12121											
FBLN2	2199	broad.mit.edu	37	chr3	13670486	13670486	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtgggctcctacacatgccAgaggaacccgctgatctgcg	13	13	1	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr3:13670486A>G	uc011avb.1	+	11	2635	c.2510A>G	c.(2509-2511)CAG>CGG	p.Q837R	FBLN2_uc011auz.1_Missense_Mutation_p.Q863R|FBLN2_uc011ava.1_Missense_Mutation_p.Q884R|FBLN2_uc011avc.1_Missense_Mutation_p.Q884R	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	837	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			TACACATGCCAGAGGAACCCG	0.652													G	13670486	G	G	13670486	3	3	170	1	0	0	0	0	1	0	0	0	5699	188	7	4	1383	4	FBLN2	3	13670486	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	66	13670486	184351944	22	12122											
KCNH8	131096	broad.mit.edu	37	chr3	19575088	19575088	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctacacttgcaaacaggcGgggctgcttatacccaagca	10	13	0	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr3:19575088G>A	uc003cbk.1	+	16	3016	c.2821G>A	c.(2821-2823)GGG>AGG	p.G941R	KCNH8_uc010hex.1_Missense_Mutation_p.G402R	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	941	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						GCAAACAGGCGGGGCTGCTTA	0.547													A	19575088	A	A	19575088	3	1	170	1	0	0	0	0	1	0	0	0	8038	1116	39	2	2883	2	KCNH8	3	19575088	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	5904602	19575088	178447342	23	12123											
RTP3	83597	broad.mit.edu	37	chr3	46542293	46542293	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagagaatgtctattcctaCgcatgccaaaaccacatctg	8	11	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr3:46542293C>T	uc003cps.1	+	2	671	c.603C>T	c.(601-603)TAC>TAT	p.Y201Y		NM_031440	NP_113628	Q9BQQ7	RTP3_HUMAN	transmembrane protein 7	201	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		TCTATTCCTACGCATGCCAAA	0.433													T	46542293	T	T	46542293	2	4	170	1	0	0	0	0	0	0	0	1	13735	547	19	1		1	RTP3	3	46542293	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	26967205	46542293	151480137	24	12124											
DNAH1	25981	broad.mit.edu	37	chr3	52433096	52433096	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcaggcctggatccaagatgGcatcccagctgtcttctgga	12	12	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr3:52433096G>C	uc011bef.1	+	76	12581	c.12320G>C	c.(12319-12321)GGC>GCC	p.G4107A	DNAH1_uc003ddv.2_Missense_Mutation_p.G965A	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	4172					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATCCAAGATGGCATCCCAGCT	0.532													C	52433096	C	C	52433096	3	2	170	1	0	0	0	0	1	0	0	0	4597	1203	42	5	12618	5	DNAH1	3	52433096	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	5890803	52433096	145589334	25	12125											
NT5DC2	64943	broad.mit.edu	37	chr3	52563292	52563292	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtcacgcaggctgatctcGttgttggcgtagatggctgc	14	10	2	2	rs148646310		TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr3:52563292G>A	uc003deo.2	-	2	604	c.180C>T	c.(178-180)AAC>AAT	p.N60N	NT5DC2_uc003dem.2_5'Flank|NT5DC2_uc003den.2_Silent_p.N97N|NT5DC2_uc010hmi.2_Silent_p.N97N|NT5DC2_uc010hmj.2_Translation_Start_Site	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	60							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		GGCTGATCTCGTTGTTGGCGT	0.592													A	52563292	A	A	52563292	2	1	170	1	0	0	0	0	0	0	0	1	10691	1136	40	1		1	NT5DC2	3	52563292	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08	130196	52563292	145459138	26	12126											
KIAA1524	57650	broad.mit.edu	37	chr3	108276241	108276241	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tttctctcaacttctctcaaCatactagcaagtgtccgtgc	5	13	4	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr3:108276241C>A	uc003dxb.3	-	17	2303	c.2034G>T	c.(2032-2034)ATG>ATT	p.M678I		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	678	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						CTTCTCTCAACATACTAGCAA	0.368													A	108276241	A	A	108276241	3	1	170	1	0	0	0	0	1	0	0	0	8239	478	17	5	703	5	KIAA1524	3	108276241	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	55712949	108276241	89746189	27	12127											
PLSCR2	57047	broad.mit.edu	37	chr3	146177634	146177634	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attttacgtatttgaaattaCctgacttaagtattccaatc	4	7	0	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr3:146177634C>T	uc003evv.1	-	3	390	c.57_splice	c.e3+1	p.Q19_splice	PLSCR2_uc003evw.1_Splice_Site_p.Q88_splice	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2						phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						TTTGAAATTACCTGACTTAAG	0.373													T	146177634	T	T	146177634	5	4	170	1	0	0	0	0	0	0	1	0	12110	521	18	3	640	3	PLSCR2	3	146177634	Splice_Site	SNP	C	TCGA-19-5959-01A-11D-1696-08	37901393	146177634	51844796	28	12128											
NFXL1	152518	broad.mit.edu	37	chr4	47864932	47864932	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acatcagctgtggttattttTctaaaaataagaaagttgat	7	4	2	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr4:47864932T>C	uc010igh.2	-	19	2424	c.2247A>G	c.(2245-2247)AGA>AGG	p.R749R	NFXL1_uc003gxo.2_Silent_p.R74R|NFXL1_uc003gxp.2_Silent_p.R749R|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Silent_p.R749R	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	749						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TGGTTATTTTTCTAAAAATAA	0.269													C	47864932	C	C	47864932	2	2	170	1	0	0	0	0	0	0	0	1	10388	1797	62	4		4	NFXL1	4	47864932	Silent	SNP	T	TCGA-19-5959-01A-11D-1696-08		47864932	143289344	29	12129											
TXK	7294	broad.mit.edu	37	chr4	48069656	48069656	+	Nonstop_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttggcattctgtttccggtcAccaggtttccgcaatctctg	9	12	3	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr4:48069656A>T	uc003gxx.3	-	15	1668	c.1582T>A	c.(1582-1584)TGA>AGA	p.*528R	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Nonstop_Mutation_p.*215R	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	528						cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GTTTCCGGTCACCAGGTTTCC	0.483													T	48069656	T	T	48069656	4	4	170	1	0	0	0	0	0	0	0	0	16783	172	6	5	5	5	TXK	4	48069656	Nonstop_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	204724	48069656	143084620	30	12130											
TMPRSS11F	389208	broad.mit.edu	37	chr4	68934340	68934340	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccttggttaacttacttccAaaagcagtgagctgctgtga	10	9	0	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr4:68934340A>G	uc003hdt.1	-	7	800	c.751T>C	c.(751-753)TGG>CGG	p.W251R	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	251	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						ACTTACTTCCAAAAGCAGTGA	0.522													G	68934340	G	G	68934340	3	3	170	1	0	0	0	0	1	0	0	0	16240	130	5	4	581	4	TMPRSS11F	4	68934340	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	20864684	68934340	122219936	31	12131											
SCARB2	950	broad.mit.edu	37	chr4	77102252	77102255	+	Splice_Site	DEL	TCCC	-	-													tatttgctttgtttctgagtTccctaaaagaaagaaaaggg					rs145870223		TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr4:77102252_77102255delTCCC	uc003hju.1	-	3	615	c.276_splice	c.e3-1	p.R92_splice	SCARB2_uc011cbu.1_Intron	NM_005506	NP_005497	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2						cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity				0			Lung(101;0.196)			GTTTCTGAGTTCCCTAAAAGAAAG	0.319													-	77102255	-	-	77102252	8	5	170	1	0	1	0	1	0	0	1	0	13882	1783	62	0	1198	0	SCARB2	4	77102252	Splice_Site	DEL	TCCC	TCGA-19-5959-01A-11D-1696-08	8167912	77102252	114052024	32	12132											
CDH18	1016	broad.mit.edu	37	chr5	19503219	19503219	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcactgatggtatgaataacCtaaagaaaagacaaactcta	7	7	1	4			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr5:19503219C>G	uc003jgc.2	-	10	1890	c.1513_splice	c.e10-1	p.V505_splice	CDH18_uc003jgd.2_Splice_Site_p.V505_splice|CDH18_uc011cnm.1_Splice_Site_p.V505_splice	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TATGAATAACCTAAAGAAAAG	0.303													G	19503219	G	G	19503219	5	3	170	1	0	0	0	0	0	0	1	0	3103	695	24	5	872	5	CDH18	5	19503219	Splice_Site	SNP	C	TCGA-19-5959-01A-11D-1696-08		19503219	161412041	33	12133											
CDH9	1007	broad.mit.edu	37	chr5	26881626	26881626	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggtatcttcttccccgccGccttcatcgttgtaggtcac	9	14	4	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr5:26881626G>A	uc003jgs.1	-	12	2158	c.1989C>T	c.(1987-1989)GGC>GGT	p.G663G	CDH9_uc011cnv.1_Silent_p.G256G	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	663	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CTTCCCCGCCGCCTTCATCGT	0.438													A	26881626	A	A	26881626	2	1	170	1	0	0	0	0	0	0	0	1	3117	1074	38	1		1	CDH9	5	26881626	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08	7378407	26881626	154033634	34	12134											
UGT3A2	167127	broad.mit.edu	37	chr5	36035988	36035988	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcgccccctgtctggaggaCgtggtcaatccagcccacca	11	17	2	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr5:36035988C>T	uc003jjz.1	-	7	1477	c.1384G>A	c.(1384-1386)GTC>ATC	p.V462I	UGT3A2_uc011cos.1_Missense_Mutation_p.V428I|UGT3A2_uc011cot.1_Missense_Mutation_p.V160I	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	462	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTCTGGAGGACGTGGTCAATC	0.617													T	36035988	T	T	36035988	3	4	170	1	0	0	0	0	1	0	0	0	16961	536	19	1	191	1	UGT3A2	5	36035988	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	9154362	36035988	144879272	35	12135											
PCDHA7	56141	broad.mit.edu	37	chr5	140215418	140215418	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcggcgggggacgcggacGcgcagaagaacgcgctggtg	20	10	0	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr5:140215418G>A	uc003lhq.2	+	1	1450	c.1450G>A	c.(1450-1452)GCG>ACG	p.A484T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A484T	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	484	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGCGGACGCGCAGAAGAA	0.677													A	140215418	A	A	140215418	3	1	170	1	0	0	0	0	1	0	0	0	11529	1087	38	1	1452	1	PCDHA7	5	140215418	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	104179430	140215418	40699842	36	12136											
DRD1	1812	broad.mit.edu	37	chr5	174869392	174869392	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtctggcaattcttggcGtggactgctgccctctccaa	12	12	3	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr5:174869392G>A	uc003mcz.2	-	2	1656	c.711C>T	c.(709-711)CAC>CAT	p.H237H		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	237	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	AATTCTTGGCGTGGACTGCTG	0.483													A	174869392	A	A	174869392	2	1	170	1	0	0	0	0	0	0	0	1	4756	1136	40	1		1	DRD1	5	174869392	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08	34653974	174869392	6045868	37	12137											
EEF1A1	1915	broad.mit.edu	37	chr6	74229088	74229088	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccctgtaatcatgtttttgAtaaagtctctgtgtcctggg	9	8	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr6:74229088A>G	uc003phi.2	-	2	333	c.296T>C	c.(295-297)ATC>ACC	p.I99T	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Missense_Mutation_p.I99T|EEF1A1_uc003phf.2_Missense_Mutation_p.I99T|EEF1A1_uc003phg.2_Missense_Mutation_p.I99T|EEF1A1_uc003phh.2_Intron|EEF1A1_uc003phj.2_Missense_Mutation_p.I99T|EEF1A1_uc003phk.2_Missense_Mutation_p.I99T|EEF1A1_uc003phl.2_Intron|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	99						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						CATGTTTTTGATAAAGTCTCT	0.408											OREG0003890	type=REGULATORY REGION|Gene=LOC477388|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	G	74229088	G	G	74229088	3	3	170	1	0	0	0	0	1	0	0	0	4923	333	12	4	1116	4	EEF1A1	6	74229088	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08		74229088	96885979	38	12138											
BACH2	60468	broad.mit.edu	37	chr6	90660866	90660866	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggccccagctggggccgtgGgggtaggggcagggctgggc	23	11	0	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr6:90660866G>A	uc011eab.1	-	7	1768	c.959C>T	c.(958-960)CCC>CTC	p.P320L	BACH2_uc003pnw.2_Missense_Mutation_p.P320L|BACH2_uc010kch.2_Missense_Mutation_p.P320L	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	320						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TGGGGCCGTGGGGGTAGGGGC	0.637													A	90660866	A	A	90660866	3	1	170	1	0	0	0	0	1	0	0	0	1284	1232	43	3	1578	3	BACH2	6	90660866	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	16431778	90660866	80454201	39	12139											
FAM184A	79632	broad.mit.edu	37	chr6	119301415	119301415	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaattcttcaagctcttgcGtaagccgctgtcgttcttgc	8	12	4	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr6:119301415G>A	uc003pyj.2	-	10	2537	c.2189C>T	c.(2188-2190)ACG>ATG	p.T730M	FAM184A_uc003pyk.3_Missense_Mutation_p.T610M|FAM184A_uc003pyl.3_Missense_Mutation_p.T610M	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	730	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						AAGCTCTTGCGTAAGCCGCTG	0.423													A	119301415	A	A	119301415	3	1	170	1	0	0	0	0	1	0	0	0	5511	1145	40	1	1269	1	FAM184A	6	119301415	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	28640549	119301415	51813652	40	12140											
TTYH3	80727	broad.mit.edu	37	chr7	2687687	2687687	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctccaagggcatcctggtgGggtgagtctgggggtgtcgg	20	8	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr7:2687687G>T	uc003smp.2	+	5	908	c.721G>T	c.(721-723)GGG>TGG	p.G241W	TTYH3_uc010ksn.2_Intron|TTYH3_uc003smq.2_Missense_Mutation_p.G70W	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	241	Helical; Name=4; (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		CATCCTGGTGGGGTGAGTCTG	0.662													T	2687687	T	T	2687687	3	4	170	1	0	0	0	0	1	0	0	0	16738	1246	43	5	739	5	TTYH3	7	2687687	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08		2687687	156450976	41	12141											
AHR	196	broad.mit.edu	37	chr7	17379818	17379818	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtcagatgcagtacaatcCagtactgccaggccaacagg	12	11	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr7:17379818C>T	uc011jxz.1	+	10	2982	c.2369C>T	c.(2368-2370)CCA>CTA	p.P790L	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	790					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					CAGTACAATCCAGTACTGCCA	0.443													T	17379818	T	T	17379818	3	4	170	1	0	0	0	0	1	0	0	0	416	594	21	3	2407	3	AHR	7	17379818	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	14692131	17379818	141758845	42	12142											
MGC26647	219557	broad.mit.edu	37	chr7	88423665	88423665	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgcaacttggtgtaagttatCgcctggtcctttagtgccta	10	9	0	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr7:88423665C>T	uc003ujv.2	-	2	774	c.592G>A	c.(592-594)GAT>AAT	p.D198N	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	198											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			TGTAAGTTATCGCCTGGTCCT	0.423													T	88423665	T	T	88423665	3	4	170	1	0	0	0	0	1	0	0	0	9550	884	31	2	173	2	MGC26647	7	88423665	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	71043847	88423665	70714998	43	12143											
RELN	5649	broad.mit.edu	37	chr7	103205876	103205876	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtccttgccattgttcagagAatactggagctgtacactgt	10	9	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr7:103205876A>G	uc003vca.2	-	34	5219	c.5059T>C	c.(5059-5061)TCT>CCT	p.S1687P	RELN_uc010liz.2_Missense_Mutation_p.S1687P	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1687	BNR 7.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTGTTCAGAGAATACTGGAGC	0.473													G	103205876	G	G	103205876	3	3	170	1	0	0	0	0	1	0	0	0	13220	246	9	4	5451	4	RELN	7	103205876	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	14782211	103205876	55932787	44	12144											
RELN	5649	broad.mit.edu	37	chr7	103338351	103338351	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttgcctgtgtccactgggtcGagactatcttctaaaacgac	9	11	2	1	rs142192165		TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr7:103338351G>A	uc003vca.2	-	10	1252	c.1092C>T	c.(1090-1092)CTC>CTT	p.L364L	RELN_uc010liz.2_Silent_p.L364L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	364					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCACTGGGTCGAGACTATCTT	0.418													A	103338351	A	A	103338351	2	1	170	1	0	0	0	0	0	0	0	1	13220	1045	37	2		2	RELN	7	103338351	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08	132475	103338351	55800312	45	12145											
CNTNAP2	26047	broad.mit.edu	37	chr7	146825899	146825899	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaacattactgatcttgccAgaaggaagaaattagagccc	8	9	2	4			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr7:146825899A>G	uc003weu.1	+	7	1570	c.1054A>G	c.(1054-1056)AGA>GGA	p.R352G		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	352	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGATCTTGCCAGAAGGAAGAA	0.388										HNSCC(39;0.1)			G	146825899	G	G	146825899	3	3	170	1	0	0	0	0	1	0	0	0	3647	180	7	4	1080	4	CNTNAP2	7	146825899	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	43487548	146825899	12312764	46	12146											
REPIN1	29803	broad.mit.edu	37	chr7	150069842	150069842	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaagtccaacctggtgtcGcaccggcgcatccacacggg	12	15	0	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr7:150069842G>A	uc010lpq.1	+	4	2001	c.1512G>A	c.(1510-1512)TCG>TCA	p.S504S	REPIN1_uc003whd.2_Silent_p.S493S|REPIN1_uc010lpr.1_Silent_p.S561S|REPIN1_uc003whc.2_Silent_p.S504S|REPIN1_uc003whe.2_Silent_p.S504S	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	504	C2H2-type 13.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			ACCTGGTGTCGCACCGGCGCA	0.667													A	150069842	A	A	150069842	2	1	170	1	0	0	0	0	0	0	0	1	13227	1074	38	1		1	REPIN1	7	150069842	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08	3243943	150069842	9068821	47	12147											
TEX15	56154	broad.mit.edu	37	chr8	30701172	30701172	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcacattcattaacctgtcGtttgtactttaagaatacat	4	8	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr8:30701172G>A	uc003xil.2	-	1	5362	c.5362C>T	c.(5362-5364)CGA>TGA	p.R1788*		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1788										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTAACCTGTCGTTTGTACTTT	0.343													A	30701172	A	A	30701172	4	1	170	1	0	0	0	0	0	1	0	0	15776	1153	40	1	3023	1	TEX15	8	30701172	Nonsense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08		30701172	115662850	48	12148											
DPY19L4	286148	broad.mit.edu	37	chr8	95792643	95792643	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtctcagcttatggaaagaGgtaaaaaaattagattttta	9	3	1	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr8:95792643G>A	uc003ygx.2	+	15	1756	c.1632G>A	c.(1630-1632)GAG>GAA	p.E544E		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	544						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					TATGGAAAGAGGtaaaaaaat	0.294													A	95792643	A	A	95792643	2	1	170	1	0	0	0	0	0	0	0	1	4743	1014	35	3		3	DPY19L4	8	95792643	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08	65091471	95792643	50571379	49	12149											
HAS2	3037	broad.mit.edu	37	chr8	122641443	122641443	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaggcaccatacagtccAaaagagaaatagtaattatc	6	7	0	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr8:122641443A>G	uc003yph.2	-	2	676	c.138T>C	c.(136-138)TTT>TTC	p.F46F		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	46	Helical; Name=2; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			CATACAGTCCAAAAGAGAAAT	0.418													G	122641443	G	G	122641443	2	3	170	1	0	0	0	0	0	0	0	1	6962	127	5	4		4	HAS2	8	122641443	Silent	SNP	A	TCGA-19-5959-01A-11D-1696-08	26848800	122641443	23722579	50	12150											
FAM75C1	441452	broad.mit.edu	37	chr9	90536465	90536465	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagggaaggttctgggggCgacctctgaggagtcagaaa	16	9	3	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr9:90536465C>T	uc010mqi.2	+	4	1672	c.1643C>T	c.(1642-1644)GCG>GTG	p.A548V	FAM75C1_uc004apq.3_Missense_Mutation_p.A531V	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GTTCTGGGGGCGACCTCTGAG	0.512													T	90536465	T	T	90536465	3	4	170	1	0	0	0	0	1	0	0	0	5623	768	27	1	1657	1	FAM75C1	9	90536465	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08		90536465	50676966	51	12151											
CTSL2	1515	broad.mit.edu	37	chr9	99799549	99799549	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcacctgattcttcactggCgtcacgtagcctttctttct	6	14	6	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr9:99799549C>T	uc004awt.2	-	4	578	c.381G>A	c.(379-381)ACG>ACA	p.T127T	CTSL2_uc010msi.2_Silent_p.T127T|CTSL2_uc004awu.2_Silent_p.T72T|CTSL2_uc010msj.1_Silent_p.T72T|CTSL2_uc010msk.2_Silent_p.T72T	NM_001333	NP_001324	O60911	CATL2_HUMAN	cathepsin L2 preproprotein	127						lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(62;0.0559)				TCTTCACTGGCGTCACGTAGC	0.483													T	99799549	T	T	99799549	2	4	170	1	0	0	0	0	0	0	0	1	4039	755	27	1		1	CTSL2	9	99799549	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	9263084	99799549	41413882	52	12152											
C9orf98	158067	broad.mit.edu	37	chr9	135702390	135702390	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcctctggcaccatgagaCggttctggatttcagattcg	11	10	3	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr9:135702390C>T	uc004cbu.1	-	8	1164	c.608G>A	c.(607-609)CGT>CAT	p.R203H	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_5'UTR	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	203						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		CACCATGAGACGGTTCTGGAT	0.517													T	135702390	T	T	135702390	3	4	170	1	0	0	0	0	1	0	0	0	2509	536	19	1	855	1	C9orf98	9	135702390	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	35902841	135702390	5511041	53	12153											
CACNA1B	774	broad.mit.edu	37	chr9	140881238	140881238	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcctgttttcctcaggttcAacttccaggatgagactccc	7	13	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr9:140881238A>G	uc004cog.2	+	15	2051	c.1906A>G	c.(1906-1908)AAC>GAC	p.N636D	CACNA1B_uc011mfd.1_Missense_Mutation_p.N167D	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	636	Extracellular (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCTCAGGTTCAACTTCCAGGA	0.602													G	140881238	G	G	140881238	3	3	170	1	0	0	0	0	1	0	0	0	2539	130	5	4	1964	4	CACNA1B	9	140881238	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	5178848	140881238	332193	54	12154											
C10orf53	282966	broad.mit.edu	37	chr10	50901822	50901822	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttttctttccttcccagctGtgttggccatagatggacat	8	11	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr10:50901822G>T	uc001jib.2	+	2	160	c.100G>T	c.(100-102)GTG>TTG	p.V34L	CHAT_uc010qgs.1_Silent_p.L542L|C10orf53_uc001jic.1_Missense_Mutation_p.V34L|C10orf53_uc001jid.1_Missense_Mutation_p.V34L	NM_001042427	NP_001035892	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53 isoform b	34											0		all_neural(218;0.107)				CTTCCCAGCTGTGTTGGCCAT	0.468													T	50901822	T	T	50901822	3	4	170	1	0	0	0	0	1	0	0	0	1606	1377	48	5	106	5	C10orf53	10	50901822	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08		50901822	84632925	55	12155											
STOX1	219736	broad.mit.edu	37	chr10	70644150	70644150	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcattacaaatacaaccaccCaggaaaataagagaatgctg	6	9	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr10:70644150C>T	uc001jos.2	+	3	685	c.598C>T	c.(598-600)CAG>TAG	p.Q200*	STOX1_uc001jor.2_Nonsense_Mutation_p.Q200*|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Nonsense_Mutation_p.Q90*	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	200						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						TACAACCACCCAGGAAAATAA	0.443													T	70644150	T	T	70644150	4	4	170	1	0	0	0	0	0	1	0	0	15318	595	21	3	608	3	STOX1	10	70644150	Nonsense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	19742328	70644150	64890597	56	12156											
PTEN	5728	broad.mit.edu	37	chr10	89692810	89692810	+	Frame_Shift_Del	DEL	A	-	-													gaccataacccaccacagctAgaacttatcaaacccttttg							TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr10:89692810delA	uc001kfb.2	+	6	1325	c.294delA	c.(292-294)CTAfs	p.L98fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	98	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.H93fs*5(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CACCACAGCTAGAACTTATCA	0.358		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89692810	-	-	89692810	7	5	170	1	0	1	0	1	0	0	0	0	12738	407	15	0	312	0	PTEN	10	89692810	Frame_Shift_Del	DEL	A	TCGA-19-5959-01A-11D-1696-08	19048660	89692810	45841937	57	12157											
KRTAP5-4	387267	broad.mit.edu	37	chr11	1643251	1643251	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcccccacagccagagcCacagcccccacagccggagc	9	21	0	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr11:1643251C>T	uc009ycy.1	-	1	118	c.31G>A	c.(31-33)GGC>AGC	p.G11S		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	25						keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		cagccagagccacagccccca	0.259													T	1643251	T	T	1643251	3	4	170	1	0	0	0	0	1	0	0	0	8563	594	21	3	617	3	KRTAP5-4	11	1643251	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08		1643251	133363265	58	12158											
SLC6A5	9152	broad.mit.edu	37	chr11	20636272	20636272	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aaatacagatcaagaactcgActttctgcatgaccgcttat	6	10	2	3			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr11:20636272A>T	uc001mqd.2	+	6	1306	c.1033A>T	c.(1033-1035)ACT>TCT	p.T345S	SLC6A5_uc009yic.2_Missense_Mutation_p.T110S	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	345	Extracellular (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	CAAGAACTCGACTTTCTGCAT	0.403													T	20636272	T	T	20636272	3	4	170	1	0	0	0	0	1	0	0	0	14687	275	10	5	1055	5	SLC6A5	11	20636272	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	18993021	20636272	114370244	59	12159											
OR8H3	390152	broad.mit.edu	37	chr11	55890213	55890213	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctcaatggcctatgatcGctatgcagcgatctgcagtc	9	13	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr11:55890213G>A	uc001nii.1	+	1	365	c.365G>A	c.(364-366)CGC>CAC	p.R122H		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					GCCTATGATCGCTATGCAGCG	0.468													A	55890213	A	A	55890213	3	1	170	1	0	0	0	0	1	0	0	0	11239	1087	38	1	367	1	OR8H3	11	55890213	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	35253941	55890213	79116303	60	12160											
OR5A1	219982	broad.mit.edu	37	chr11	59210760	59210760	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcctgggcatctatcttaCcaccctggcctggaacctgg	9	15	2	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr11:59210760C>T	uc001nnx.1	+	1	119	c.119C>T	c.(118-120)ACC>ATC	p.T40I		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						ATCTATCTTACCACCCTGGCC	0.502													T	59210760	T	T	59210760	3	4	170	1	0	0	0	0	1	0	0	0	11139	507	18	3	121	3	OR5A1	11	59210760	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	3320547	59210760	75795756	61	12161											
C11orf66	220004	broad.mit.edu	37	chr11	61249365	61249365	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggaccccctgaaattctaCgccaccagctactgcaccgc	7	18	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr11:61249365C>T	uc001nru.1	+	2	209	c.84C>T	c.(82-84)TAC>TAT	p.Y28Y	C11orf66_uc009ynq.1_Silent_p.Y28Y	NM_145017	NP_659454	Q7Z5V6	CK066_HUMAN	IIIG9 protein	28										ovary(1)	1						TGAAATTCTACGCCACCAGCT	0.622													T	61249365	T	T	61249365	2	4	170	1	0	0	0	0	0	0	0	1	1656	547	19	1		1	C11orf66	11	61249365	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	2038605	61249365	73757151	62	12162											
OVOL1	5017	broad.mit.edu	37	chr11	65561705	65561705	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagagaccatggcttcctgCgcaccaagatgaaggtaatg	12	10	0	3			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr11:65561705C>T	uc001ofp.2	+	2	620	c.304C>T	c.(304-306)CGC>TGC	p.R102C	OVOL1_uc001ofq.2_Missense_Mutation_p.R40C	NM_004561	NP_004552	O14753	OVOL1_HUMAN	OVO-like 1 binding protein	102					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.17)		TGGCTTCCTGCGCACCAAGAT	0.612													T	65561705	T	T	65561705	3	4	170	1	0	0	0	0	1	0	0	0	11326	768	27	1	310	1	OVOL1	11	65561705	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	4312340	65561705	69444811	63	12163											
KRTAP5-8	57830	broad.mit.edu	37	chr11	71249153	71249153	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccggctgtgggggctgcGgctctggctgtgggggatgt	21	9	1	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr11:71249153G>A	uc001oqr.1	+	1	83	c.52G>A	c.(52-54)GGC>AGC	p.G18S		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	18						extracellular region|keratin filament	structural constituent of epidermis				0						TGGGGGCTGCGGCTCTGGCTG	0.652													A	71249153	A	A	71249153	3	1	170	1	0	0	0	0	1	0	0	0	8567	1116	39	2	54	2	KRTAP5-8	11	71249153	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	5687448	71249153	63757363	64	12164											
ARRB1	408	broad.mit.edu	37	chr11	74979943	74979943	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctgctcaccttcccgatgCgggggttcctctttgggctt	11	13	3	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr11:74979943C>T	uc001owe.1	-	14	1305	c.1083G>A	c.(1081-1083)CCG>CCA	p.P361P	ARRB1_uc001owf.1_Silent_p.P353P	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	361	Interaction with TRAF6.				G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						CTTCCCGATGCGGGGGTTCCT	0.622													T	74979943	T	T	74979943	2	4	170	1	0	0	0	0	0	0	0	1	980	755	27	1		1	ARRB1	11	74979943	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	3730790	74979943	60026573	65	12165											
GRIN2B	2904	broad.mit.edu	37	chr12	13716218	13716218	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttcaggcttacgctgcgcggGgccagggcggcttcttcctt	14	13	2	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr12:13716218G>C	uc001rbt.2	-	13	4133	c.3954C>G	c.(3952-3954)GCC>GCG	p.A1318A		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1318	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGCTGCGCGGGGCCAGGGCGG	0.587													C	13716218	C	C	13716218	2	2	170	1	0	0	0	0	0	0	0	1	6780	1219	43	5		5	GRIN2B	12	13716218	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08		13716218	120135677	66	12166											
OAS1	4938	broad.mit.edu	37	chr12	113346549	113346549	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacgctggggcaacccccGtgcgctcagcttcgtactga	11	16	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr12:113346549G>A	uc001tud.2	+	2	495	c.389G>A	c.(388-390)CGT>CAT	p.R130H	OAS1_uc010syn.1_Missense_Mutation_p.R129H|OAS1_uc010syo.1_Missense_Mutation_p.R129H|OAS1_uc001tub.2_Missense_Mutation_p.R130H|OAS1_uc001tuc.2_Missense_Mutation_p.R130H|OAS1_uc009zwf.2_Missense_Mutation_p.R129H	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	130	Necessary for binding to dsRNA.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2						GGCAACCCCCGTGCGCTCAGC	0.577													A	113346549	A	A	113346549	3	1	170	1	0	0	0	0	1	0	0	0	10799	1145	40	1	395	1	OAS1	12	113346549	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	99630331	113346549	20505346	67	12167											
OR4K15	81127	broad.mit.edu	37	chr14	20443959	20443959	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaaacctgtcatttatagaCgtatgtgttgcctcttttgc	8	9	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr14:20443959C>T	uc010tkx.1	+	1	282	c.282C>T	c.(280-282)GAC>GAT	p.D94D		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	94	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATTTATAGACGTATGTGTTG	0.453													T	20443959	T	T	20443959	2	4	170	1	0	0	0	0	0	0	0	1	11070	535	19	1		1	OR4K15	14	20443959	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08		20443959	86905581	68	12168											
FLJ10357	55701	broad.mit.edu	37	chr14	21543075	21543075	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gggctcttagccgaggagggGacagtgccccactgagccct	15	13	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr14:21543075G>T	uc001vzp.2	+	3	1215	c.1186G>T	c.(1186-1188)GAC>TAC	p.D396Y	FLJ10357_uc001vzn.1_Missense_Mutation_p.D396Y|FLJ10357_uc001vzo.1_Intron|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_5'UTR	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	396					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		CCGAGGAGGGGACAGTGCCCC	0.597													T	21543075	T	T	21543075	3	4	170	1	0	0	0	0	1	0	0	0	5926	1174	41	5	1196	5	FLJ10357	14	21543075	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	1099116	21543075	85806465	69	12169											
CHD8	57680	broad.mit.edu	37	chr14	21871175	21871175	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taagacaatgaattcctttaCctgcaggtcattttgtggat	8	7	1	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr14:21871175C>T	uc001was.1	-	18	2971	c.2877_splice	c.e18+1	p.Q959_splice	CHD8_uc001war.1_Splice_Site_p.Q855_splice|CHD8_uc001wav.1_Splice_Site_p.Q401_splice	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8						ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AATTCCTTTACCTGCAGGTCA	0.403													T	21871175	T	T	21871175	5	4	170	1	0	0	0	0	0	0	1	0	3331	521	18	3	4114	3	CHD8	14	21871175	Splice_Site	SNP	C	TCGA-19-5959-01A-11D-1696-08	328100	21871175	85478365	70	12170											
ACTN1	87	broad.mit.edu	37	chr14	69356891	69356891	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtggatggaggccttctgcCggaacttctctgccaggtgg	15	11	2	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr14:69356891C>T	uc001xkl.2	-	11	1509	c.1199G>A	c.(1198-1200)CGG>CAG	p.R400Q	ACTN1_uc001xkk.2_5'Flank|ACTN1_uc010ttb.1_Missense_Mutation_p.R335Q|ACTN1_uc001xkm.2_Missense_Mutation_p.R400Q|ACTN1_uc001xkn.2_Missense_Mutation_p.R400Q|ACTN1_uc001xko.1_Missense_Mutation_p.R335Q|ACTN1_uc010ttd.1_Missense_Mutation_p.R379Q	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	400	Spectrin 2.|Interaction with DDN.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GGCCTTCTGCCGGAACTTCTC	0.647													T	69356891	T	T	69356891	3	4	170	1	0	0	0	0	1	0	0	0	204	652	23	2	1593	2	ACTN1	14	69356891	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	47485716	69356891	37992649	71	12171											
ITGA11	22801	broad.mit.edu	37	chr15	68643617	68643617	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaccgcatatcttgttacGttgtctctttcgctttgctg	8	12	2	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr15:68643617G>A	uc002ari.2	-	8	960	c.873C>T	c.(871-873)AAC>AAT	p.N291N	ITGA11_uc010bib.2_Silent_p.N291N	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	291	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	ATCTTGTTACGTTGTCTCTTT	0.552													A	68643617	A	A	68643617	2	1	170	1	0	0	0	0	0	0	0	1	7874	1136	40	1		1	ITGA11	15	68643617	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08		68643617	33887775	72	12172											
CSPG4	1464	broad.mit.edu	37	chr15	75980091	75980091	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttgcccgtcggacacctgCagctggatccagccacggtc	12	15	0	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr15:75980091C>T	uc002baw.2	-	3	3408	c.3315G>A	c.(3313-3315)CTG>CTA	p.L1105L		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1105	Interaction with COL5A1 (By similarity).|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|CSPG 6.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CGGACACCTGCAGCTGGATCC	0.657													T	75980091	T	T	75980091	2	4	170	1	0	0	0	0	0	0	0	1	3960	697	25	3		3	CSPG4	15	75980091	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	7336474	75980091	26551301	73	12173											
C15orf27	123591	broad.mit.edu	37	chr15	76430102	76430102	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcatctcccaacaagtagaCgaagaaaccaagagcattgc	7	11	2	3			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr15:76430102C>T	uc002bbq.2	+	3	248	c.93C>T	c.(91-93)GAC>GAT	p.D31D	C15orf27_uc010bkp.2_Translation_Start_Site|C15orf27_uc002bbr.2_Translation_Start_Site	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	31						integral to membrane					0						AACAAGTAGACGAAGAAACCA	0.537													T	76430102	T	T	76430102	2	4	170	1	0	0	0	0	0	0	0	1	1788	535	19	1		1	C15orf27	15	76430102	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	450011	76430102	26101290	74	12174											
C15orf26	161502	broad.mit.edu	37	chr15	81429012	81429012	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attcagtcccatctgaaagaCgaattagaggtaccctgtgg	10	9	2	3			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr15:81429012C>T	uc002bgb.2	+	3	342	c.315C>T	c.(313-315)GAC>GAT	p.D105D	C15orf26_uc010blp.1_Silent_p.D80D	NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	105											0						ATCTGAAAGACGAATTAGAGG	0.448													T	81429012	T	T	81429012	2	4	170	1	0	0	0	0	0	0	0	1	1787	535	19	1		1	C15orf26	15	81429012	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	4998910	81429012	21102380	75	12175											
HAPLN3	145864	broad.mit.edu	37	chr15	89430480	89430480	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agccgttgtagaagggcagtCcgtaggagccgggcagcagg	18	9	0	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr15:89430480C>A	uc002bnc.2	-	2	178	c.50G>T	c.(49-51)GGA>GTA	p.G17V	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Missense_Mutation_p.G79V	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	17					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					GAAGGGCAGTCCGTAGGAGCC	0.642													A	89430480	A	A	89430480	3	1	170	1	0	0	0	0	1	0	0	0	6956	855	30	5	1048	5	HAPLN3	15	89430480	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	8001468	89430480	13100912	76	12176											
GNPTG	84572	broad.mit.edu	37	chr16	1412483	1412483	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgccagaggccctgcagcGgcagtgggaccaggtagagc	16	13	0	2	rs139997459		TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr16:1412483G>A	uc002clm.2	+	8	592	c.557G>A	c.(556-558)CGG>CAG	p.R186Q		NM_032520	NP_115909	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase, gamma	186						extracellular region|Golgi apparatus	protein binding			central_nervous_system(1)	1		Hepatocellular(780;0.0893)				GCCCTGCAGCGGCAGTGGGAC	0.682													A	1412483	A	A	1412483	3	1	170	1	0	0	0	0	1	0	0	0	6546	1116	39	2	587	2	GNPTG	16	1412483	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08		1412483	88942270	77	12177											
TEKT5	146279	broad.mit.edu	37	chr16	10788509	10788509	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgtgggcaggatggtgggCggccgcagggtactggtgct	21	7	0	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr16:10788509C>T	uc002czz.1	-	1	294	c.222G>A	c.(220-222)CCG>CCA	p.P74P		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	74					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						GGATGGTGGGCGGCCGCAGGG	0.642													T	10788509	T	T	10788509	2	4	170	1	0	0	0	0	0	0	0	1	15753	755	27	1		1	TEKT5	16	10788509	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	9376026	10788509	79566244	78	12178											
ITGAM	3684	broad.mit.edu	37	chr16	31336846	31336846	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgctcacagcgatcctggcGcctggcctgtgagtctgcct	13	15	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr16:31336846G>A	uc002ebq.2	+	21	2629	c.2531G>A	c.(2530-2532)CGC>CAC	p.R844H	ITGAM_uc002ebr.2_Missense_Mutation_p.R845H|ITGAM_uc010can.2_Missense_Mutation_p.R250H|ITGAM_uc002ebs.1_Missense_Mutation_p.R250H	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	844	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CGATCCTGGCGCCTGGCCTGT	0.602													A	31336846	A	A	31336846	3	1	170	1	0	0	0	0	1	0	0	0	7887	1087	38	1	2616	1	ITGAM	16	31336846	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	20548337	31336846	59017907	79	12179											
DPEP3	64180	broad.mit.edu	37	chr16	68010069	68010069	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcttcctcgctccagctaCgactcagcaactcctctatc	5	18	3	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr16:68010069C>T	uc002evc.3	-	9	1326	c.1232G>A	c.(1231-1233)CGT>CAT	p.R411H	DPEP3_uc010cex.2_Missense_Mutation_p.R410H	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	386					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		GCTCCAGCTACGACTCAGCAA	0.577													T	68010069	T	T	68010069	3	4	170	1	0	0	0	0	1	0	0	0	4715	536	19	1	317	1	DPEP3	16	68010069	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	36673223	68010069	22344684	80	12180											
CNTNAP4	85445	broad.mit.edu	37	chr16	76482757	76482757	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcattcagtgctcatccagcGtttgggcaaacaagtcaact	9	11	3	0	rs148969138		TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr16:76482757G>A	uc002feu.1	+	8	1221	c.836G>A	c.(835-837)CGT>CAT	p.R279H	CNTNAP4_uc002fev.1_Missense_Mutation_p.R191H|CNTNAP4_uc010chb.1_Missense_Mutation_p.R254H|CNTNAP4_uc002fex.1_Missense_Mutation_p.R282H|CNTNAP4_uc002few.2_Missense_Mutation_p.R254H	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	279	Extracellular (Potential).|Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CTCATCCAGCGTTTGGGCAAA	0.483													A	76482757	A	A	76482757	3	1	170	1	0	0	0	0	1	0	0	0	3649	1145	40	1	871	1	CNTNAP4	16	76482757	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	8472688	76482757	13871996	81	12181											
SDR42E1	93517	broad.mit.edu	37	chr16	82033639	82033639	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttcgattgagttgctcccGccctgacataccataagagg	10	11	0	3			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr16:82033639G>A	uc002fgu.2	-	3	387	c.259C>T	c.(259-261)CGG>TGG	p.R87W		NM_145168	NP_660151	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E,	87					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding				0						AGTTGCTCCCGCCCTGACATA	0.498													A	82033639	A	A	82033639	3	1	170	1	0	0	0	0	1	0	0	0	13973	1086	38	1	926	1	SDR42E1	16	82033639	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	5550882	82033639	8321114	82	12182											
CDH13	1012	broad.mit.edu	37	chr16	83704506	83704506	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcctacaccatcatcaacGgaaaccccgggcagagcttt	8	15	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr16:83704506G>A	uc002fgx.2	+	9	1333	c.1213G>A	c.(1213-1215)GGA>AGA	p.G405R	CDH13_uc010vns.1_Missense_Mutation_p.G452R|CDH13_uc010vnt.1_Missense_Mutation_p.G151R|CDH13_uc010vnu.1_Missense_Mutation_p.G366R	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	405	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CATCATCAACGGAAACCCCGG	0.498													A	83704506	A	A	83704506	3	1	170	1	0	0	0	0	1	0	0	0	3099	1117	39	2	1247	2	CDH13	16	83704506	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	1670867	83704506	6650247	83	12183											
TNFAIP1	7126	broad.mit.edu	37	chr17	26666722	26666722	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctcaaggccatgttcagtGggcgcatggaggtgctgacc	15	10	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr17:26666722G>A	uc002hax.1	+	2	194	c.175G>A	c.(175-177)GGG>AGG	p.G59R	TNFAIP1_uc002hay.2_Missense_Mutation_p.G59R|TNFAIP1_uc010waf.1_Intron	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	59	BTB.				apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CATGTTCAGTGGGCGCATGGA	0.617													A	26666722	A	A	26666722	3	1	170	1	0	0	0	0	1	0	0	0	16269	1348	47	3	177	3	TNFAIP1	17	26666722	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08		26666722	54528488	84	12184											
KRT32	3882	broad.mit.edu	37	chr17	39619277	39619277	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtagcgggcctcactctccGtcagcgtgttttccagggag	13	12	3	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr17:39619277G>A	uc002hwr.2	-	6	1083	c.1022C>T	c.(1021-1023)ACG>ATG	p.T341M		NM_002278	NP_002269	Q14532	K1H2_HUMAN	keratin 32	341	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000812)				CTCACTCTCCGTCAGCGTGTT	0.572													A	39619277	A	A	39619277	3	1	170	1	0	0	0	0	1	0	0	0	8468	1145	40	1	332	1	KRT32	17	39619277	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	12952555	39619277	41575933	85	12185											
DCC	1630	broad.mit.edu	37	chr18	50451729	50451729	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tattagtgcctctgcagagcTcacagtcttgggtaagttag	11	8	3	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr18:50451729T>C	uc002lfe.1	+	5	1561	c.974T>C	c.(973-975)CTC>CCC	p.L325P	DCC_uc010xdr.1_Missense_Mutation_p.L173P	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	325	Extracellular (Potential).|Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCTGCAGAGCTCACAGTCTTG	0.388													C	50451729	C	C	50451729	3	2	170	1	0	0	0	0	1	0	0	0	4282	1551	54	4	992	4	DCC	18	50451729	Missense_Mutation	SNP	T	TCGA-19-5959-01A-11D-1696-08		50451729	27625519	86	12186											
ATCAY	85300	broad.mit.edu	37	chr19	3909561	3909561	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacggtgccacgccccggcGgaggatgcctggaatcggct	16	13	0	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr19:3909561G>A	uc002lyy.3	+	7	1155	c.725G>A	c.(724-726)CGG>CAG	p.R242Q	ATCAY_uc010xhz.1_Missense_Mutation_p.R248Q|ATCAY_uc010dts.2_5'UTR	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	242	CRAL-TRIO.				transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		ACGCCCCGGCGGAGGATGCCT	0.592													A	3909561	A	A	3909561	3	1	170	1	0	0	0	0	1	0	0	0	1077	1116	39	2	747	2	ATCAY	19	3909561	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08		3909561	55219422	87	12187											
TNFSF9	8744	broad.mit.edu	37	chr19	6534936	6534936	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcttgctgcacctgagtgcCggccagcgcctgggcgtcca	14	16	0	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr19:6534936C>T	uc002mfh.2	+	3	662	c.624C>T	c.(622-624)GCC>GCT	p.A208A		NM_003811	NP_003802	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily,	208	Extracellular (Potential).				apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						ACCTGAGTGCCGGCCAGCGCC	0.697													T	6534936	T	T	6534936	2	4	170	1	0	0	0	0	0	0	0	1	16309	639	23	2		2	TNFSF9	19	6534936	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	2625375	6534936	52594047	88	12188											
DOCK6	57572	broad.mit.edu	37	chr19	11361720	11361720	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gctagaggcaccactgcttcGaggggtgtcttccggggagc	16	11	1	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr19:11361720G>A	uc002mqs.3	-	6	591	c.550C>T	c.(550-552)CGA>TGA	p.R184*		NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	184					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CCACTGCTTCGAGGGGTGTCT	0.567													A	11361720	A	A	11361720	4	1	170	1	0	0	0	0	0	1	0	0	4691	1066	37	2	5765	2	DOCK6	19	11361720	Nonsense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	4826784	11361720	47767263	89	12189											
OR10H5	284433	broad.mit.edu	37	chr19	15905063	15905063	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcctgtgtgccctctccatcAccgagatcctctacaccgtg	7	17	3	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr19:15905063A>G	uc010xos.1	+	1	205	c.205A>G	c.(205-207)ACC>GCC	p.T69A		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCTCTCCATCACCGAGATCCT	0.622													G	15905063	G	G	15905063	3	3	170	1	0	0	0	0	1	0	0	0	10909	159	6	4	207	4	OR10H5	19	15905063	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	4543343	15905063	43223920	90	12190											
HIF3A	64344	broad.mit.edu	37	chr19	46832519	46832519	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctacatctccatggatgatgActtccagctcaacgccagcg	8	14	2	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr19:46832519A>G	uc002peh.2	+	12	1525	c.1496A>G	c.(1495-1497)GAC>GGC	p.D499G	HIF3A_uc002peg.3_Missense_Mutation_p.D499G|HIF3A_uc002pei.3_Missense_Mutation_p.D443G|HIF3A_uc002pej.1_Intron|HIF3A_uc002pek.2_Missense_Mutation_p.D443G|HIF3A_uc010xxy.1_Missense_Mutation_p.D430G|HIF3A_uc002pel.2_Missense_Mutation_p.D497G|HIF3A_uc010xxz.1_Missense_Mutation_p.D448G	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	499	NTAD.|ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		ATGGATGATGACTTCCAGCTC	0.552													G	46832519	G	G	46832519	3	3	170	1	0	0	0	0	1	0	0	0	7105	275	10	4	1566	4	HIF3A	19	46832519	Missense_Mutation	SNP	A	TCGA-19-5959-01A-11D-1696-08	30927456	46832519	12296464	91	12191											
FPR2	2358	broad.mit.edu	37	chr19	52272915	52272915	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcagccccaactaatgacaCggctgccaattctgcttcac	6	16	3	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr19:52272915C>T	uc002pxr.2	+	2	1049	c.1004C>T	c.(1003-1005)ACG>ATG	p.T335M	FPR2_uc002pxs.3_Missense_Mutation_p.T335M|FPR2_uc010epf.2_Missense_Mutation_p.T335M	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	335	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						ACTAATGACACGGCTGCCAAT	0.537													T	52272915	T	T	52272915	3	4	170	1	0	0	0	0	1	0	0	0	6039	536	19	1	1006	1	FPR2	19	52272915	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	5440396	52272915	6856068	92	12192											
ZNF71	58491	broad.mit.edu	37	chr19	57133247	57133247	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggcaaggccttcagccagCgcatgaacctcactgtgcac	11	15	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr19:57133247C>T	uc002qnm.3	+	3	830	c.592C>T	c.(592-594)CGC>TGC	p.R198C		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	198	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		CTTCAGCCAGCGCATGAACCT	0.637													T	57133247	T	T	57133247	3	4	170	1	0	0	0	0	1	0	0	0	18111	768	27	1	594	1	ZNF71	19	57133247	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	4860332	57133247	1995736	93	12193											
CHGB	1114	broad.mit.edu	37	chr20	5903871	5903871	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgaggacctggagtgggagCgctataggggcagaggaagt	19	6	0	2	rs144051265		TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr20:5903871C>T	uc002wmg.2	+	4	1387	c.1081C>T	c.(1081-1083)CGC>TGC	p.R361C	CHGB_uc010zqz.1_Missense_Mutation_p.R44C	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	361						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GGAGTGGGAGCGCTATAGGGG	0.527													T	5903871	T	T	5903871	3	4	170	1	0	0	0	0	1	0	0	0	3339	768	27	1	1095	1	CHGB	20	5903871	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08		5903871	57121649	94	12194											
SNTA1	6640	broad.mit.edu	37	chr20	32000203	32000203	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttttcagttagcagggcCagggtgggggctgtgccccc	15	12	1	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr20:32000203C>T	uc002wzd.1	-	5	1211	c.939G>A	c.(937-939)CTG>CTA	p.L313L	SNTA1_uc010zuf.1_Intron	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	313	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						TTAGCAGGGCCAGGGTGGGGG	0.652													T	32000203	T	T	32000203	2	4	170	1	0	0	0	0	0	0	0	1	14871	581	21	3		3	SNTA1	20	32000203	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	26096332	32000203	31025317	95	12195											
SRMS	6725	broad.mit.edu	37	chr20	62178625	62178625	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcagctccccgccacaccgCgccgtgaagtcatagagcgc	10	18	2	2	rs140773907		TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr20:62178625C>T	uc002yfi.1	-	1	233	c.192G>A	c.(190-192)GCG>GCA	p.A64A		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	64	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			CGCCACACCGCGCCGTGAAGT	0.692													T	62178625	T	T	62178625	2	4	170	1	0	0	0	0	0	0	0	1	15151	755	27	1		1	SRMS	20	62178625	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	30178422	62178625	846895	96	12196											
PCNT	5116	broad.mit.edu	37	chr21	47850134	47850134	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgcgaggtgcagcaggaggTcctccagctgaggtgcgcct	16	12	0	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chr21:47850134T>C	uc002zji.3	+	36	8008	c.7901T>C	c.(7900-7902)GTC>GCC	p.V2634A	PCNT_uc002zjj.2_Missense_Mutation_p.V2516A	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2634	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CAGCAGGAGGTCCTCCAGCTG	0.607													C	47850134	C	C	47850134	3	2	170	1	0	0	0	0	1	0	0	0	11590	1667	58	4	8043	4	PCNT	21	47850134	Missense_Mutation	SNP	T	TCGA-19-5959-01A-11D-1696-08		47850134	279761	97	12197											
ZRSR2	8233	broad.mit.edu	37	chrX	15841126	15841126	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaaagtagtcgtcacaggGggaagaaatctcacaaacgc	12	8	2	1			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chrX:15841126G>A	uc004cxg.3	+	11	1255	c.1210G>A	c.(1210-1212)GGG>AGG	p.G404R		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	404					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					TCGTCACAGGGGGAAGAAATC	0.552													A	15841126	A	A	15841126	3	1	170	1	0	0	0	0	1	0	0	0	18222	1232	43	3	1252	3	ZRSR2	23	15841126	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08		15841126	139429434	98	12198											
FTHL17	53940	broad.mit.edu	37	chrX	31089936	31089936	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagttctccagggccacgtcGtcccggttgaagtagaaggc	13	11	1	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chrX:31089936G>A	uc004dcl.1	-	1	238	c.135C>T	c.(133-135)GAC>GAT	p.D45D		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	45	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0						GGGCCACGTCGTCCCGGTTGA	0.582													A	31089936	A	A	31089936	2	1	170	1	0	0	0	0	0	0	0	1	6083	1136	40	1		1	FTHL17	23	31089936	Silent	SNP	G	TCGA-19-5959-01A-11D-1696-08	15248810	31089936	124180624	99	12199											
HUWE1	10075	broad.mit.edu	37	chrX	53591568	53591568	+	Frame_Shift_Del	DEL	C	-	-													gaactgagcacctcaggctgCccagcaatcaccactgagtc							TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chrX:53591568delC	uc004dsp.2	-	51	7398	c.6996delG	c.(6994-6996)GGGfs	p.G2332fs	HUWE1_uc004dsn.2_Frame_Shift_Del_p.G1156fs	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2332	Glu-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CCTCAGGCTGCCCAGCAATCA	0.562													-	53591568	-	-	53591568	7	5	170	1	0	1	0	1	0	0	0	0	7461	726	26	0	6264	0	HUWE1	23	53591568	Frame_Shift_Del	DEL	C	TCGA-19-5959-01A-11D-1696-08	22501632	53591568	101678992	100	12200											
FAM155B	27112	broad.mit.edu	37	chrX	68725733	68725733	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccttttgcgacacctacaCggtctgggacttgctgctgg	11	13	1	0			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chrX:68725733C>T	uc004dxk.2	+	1	656	c.608C>T	c.(607-609)ACG>ATG	p.T203M		NM_015686	NP_056501	O75949	F155B_HUMAN	transmembrane protein 28	203						integral to membrane				ovary(1)|breast(1)	2						GACACCTACACGGTCTGGGAC	0.632													T	68725733	T	T	68725733	3	4	170	1	0	0	0	0	1	0	0	0	5466	536	19	1	610	1	FAM155B	23	68725733	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	15134165	68725733	86544827	101	12201											
AIFM1	9131	broad.mit.edu	37	chrX	129272643	129272643	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtaattgatttgacttcccGtgaaatcttctccaagcttc	6	11	2	3			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chrX:129272643G>A	uc004evg.2	-	9	1070	c.892C>T	c.(892-894)CGG>TGG	p.R298W	AIFM1_uc011mur.1_5'Flank|AIFM1_uc011mus.1_Missense_Mutation_p.R298W|AIFM1_uc004evh.2_Missense_Mutation_p.R294W|AIFM1_uc004evi.2_Intron|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	298	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						TTGACTTCCCGTGAAATCTTC	0.433													A	129272643	A	A	129272643	3	1	170	1	0	0	0	0	1	0	0	0	426	1144	40	1	993	1	AIFM1	23	129272643	Missense_Mutation	SNP	G	TCGA-19-5959-01A-11D-1696-08	60546910	129272643	25997917	102	12202											
GPR112	139378	broad.mit.edu	37	chrX	135431775	135431775	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcacttccacattggctgaCgttaagcacacatttgagaa	7	10	1	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chrX:135431775C>T	uc004ezu.1	+	6	6201	c.5910C>T	c.(5908-5910)GAC>GAT	p.D1970D	GPR112_uc010nsb.1_Silent_p.D1765D|GPR112_uc010nsc.1_Silent_p.D1737D	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1970	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CATTGGCTGACGTTAAGCACA	0.413													T	135431775	T	T	135431775	2	4	170	1	0	0	0	0	0	0	0	1	6629	535	19	1		1	GPR112	23	135431775	Silent	SNP	C	TCGA-19-5959-01A-11D-1696-08	6159132	135431775	19838785	103	12203											
SRPK3	26576	broad.mit.edu	37	chrX	153049211	153049211	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accctggctctgacagcagaCcggtaagctgtccaaaaaca	9	13	1	2			TCGA-19-5959-01A-11D-1696-08	TCGA-19-5959-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	dd3e4733-7154-4162-9a61-a3a685e5f561	3a0f00b9-668f-4afb-8d07-998ed98c2181	g.chrX:153049211C>A	uc004fil.2	+	9	811	c.779C>A	c.(778-780)ACC>AAC	p.T260N	SRPK3_uc004fik.2_Missense_Mutation_p.T326N|SRPK3_uc010nul.2_Missense_Mutation_p.T217N|SRPK3_uc004fin.2_Missense_Mutation_p.T259N|SRPK3_uc004fim.2_Missense_Mutation_p.T259N	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	260	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TGACAGCAGACCGGTAAGCTG	0.622													A	153049211	A	A	153049211	3	1	170	1	0	0	0	0	1	0	0	0	15160	521	18	5	813	5	SRPK3	23	153049211	Missense_Mutation	SNP	C	TCGA-19-5959-01A-11D-1696-08	17617436	153049211	2221349	104	12204											
MTF1	4520	broad.mit.edu	37	chr1	38297931	38297931	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	acttaccgtactggaattttCtcgcaattcagaatctgtgg	8	9	3	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr1:38297931C>G	uc001cce.1	-	7	1195	c.1054G>C	c.(1054-1056)GAA>CAA	p.E352Q	MTF1_uc009vvj.1_Missense_Mutation_p.E43Q	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	352						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CTGGAATTTTCTCGCAATTCA	0.393													G	38297931	G	G	38297931	3	3	171	1	0	0	0	0	1	0	0	0	9922	922	32	5	1227	5	MTF1	1	38297931	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08		38297931	210952690	1	12205											
BSND	7809	broad.mit.edu	37	chr1	55470704	55470704	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgcttgcagatcaccttcGtccctgctgactctgacttt	7	13	2	3			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr1:55470704G>A	uc001cye.2	+	2	430	c.187G>A	c.(187-189)GTC>ATC	p.V63I		NM_057176	NP_476517	Q8WZ55	BSND_HUMAN	barttin	63	Cytoplasmic (Potential).					basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				ovary(1)|skin(1)	2						GATCACCTTCGTCCCTGCTGA	0.582													A	55470704	A	A	55470704	3	1	171	1	0	0	0	0	1	0	0	0	1531	1145	40	1	193	1	BSND	1	55470704	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	17172773	55470704	193779917	2	12206											
HFM1	164045	broad.mit.edu	37	chr1	91840986	91840986	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagcagcctgttgcacaccCttccttgttgcacaaaactg	8	13	0	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr1:91840986C>T	uc001doa.3	-	13	1714	c.1614G>A	c.(1612-1614)AAG>AAA	p.K538K	HFM1_uc010osu.1_Silent_p.K217K|HFM1_uc010osv.1_Silent_p.K222K	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	538	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GTTGCACACCCTTCCTTGTTG	0.308													T	91840986	T	T	91840986	2	4	171	1	0	0	0	0	0	0	0	1	7083	680	24	3		3	HFM1	1	91840986	Silent	SNP	C	TCGA-19-5960-01A-11D-1696-08	36370282	91840986	157409635	3	12207											
TCHH	7062	broad.mit.edu	37	chr1	152083402	152083402	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actgccatgtgaagtcccggCgctgctcctcttcctgctgc	10	16	1	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr1:152083402C>G	uc001ezp.2	-	2	2291	c.2291G>C	c.(2290-2292)CGC>CCC	p.R764P	TCHH_uc009wne.1_Missense_Mutation_p.R764P	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	764					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAAGTCCCGGCGCTGCTCCTC	0.682													G	152083402	G	G	152083402	3	3	171	1	0	0	0	0	1	0	0	0	15697	768	27	5	3544	5	TCHH	1	152083402	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08	60242416	152083402	97167219	4	12208											
NCF2	4688	broad.mit.edu	37	chr1	183546838	183546838	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	aaggtctttgatagccaaatCatatctgcaggacagaggga	11	7	3	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr1:183546838C>A	uc001gqj.3	-	3	537	c.262G>T	c.(262-264)GAT>TAT	p.D88Y	NCF2_uc010pod.1_Missense_Mutation_p.D88Y|NCF2_uc010poe.1_Missense_Mutation_p.D88Y|NCF2_uc001gqk.3_Missense_Mutation_p.D88Y	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	88	TPR 2.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						ATAGCCAAATCATATCTGCAG	0.443													A	183546838	A	A	183546838	3	1	171	1	0	0	0	0	1	0	0	0	10217	826	29	5	1370	5	NCF2	1	183546838	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08	31463436	183546838	65703783	5	12209											
OBSCN	84033	broad.mit.edu	37	chr1	228505193	228505193	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatcccccagaggatgctgaGgtggtggctcgcagcagcca	15	12	0	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr1:228505193G>T	uc009xez.1	+	52	13634	c.13590G>T	c.(13588-13590)GAG>GAT	p.E4530D	OBSCN_uc001hsn.2_Missense_Mutation_p.E4530D	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4530	Fibronectin type-III 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGGATGCTGAGGTGGTGGCTC	0.647													T	228505193	T	T	228505193	3	4	171	1	0	0	0	0	1	0	0	0	10812	991	35	5	13792	5	OBSCN	1	228505193	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	44958355	228505193	20745428	6	12210											
EPT1	85465	broad.mit.edu	37	chr2	26596336	26596336	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcatgtgtttactttgttGtgactgtttattccatcttt	8	6	2	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr2:26596336G>A	uc010ykz.1	+	5	559	c.412G>A	c.(412-414)GTG>ATG	p.V138M	EPT1_uc010eyl.1_RNA	NM_033505	NP_277040	Q9C0D9	EPT1_HUMAN	selenoprotein I	138	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding				0						TTACTTTGTTGTGACTGTTTA	0.433													A	26596336	A	A	26596336	3	1	171	1	0	0	0	0	1	0	0	0	5199	1377	48	3	430	3	EPT1	2	26596336	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		26596336	216603037	7	12211											
TTN	7273	broad.mit.edu	37	chr2	179432795	179432795	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccaggtggtaacctatgaCggggcttccaccattgttga	11	11	0	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr2:179432795C>T	uc010zfg.1	-	275	70584	c.70360G>A	c.(70360-70362)GTC>ATC	p.V23454I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V17149I|TTN_uc010zfi.1_Missense_Mutation_p.V17082I|TTN_uc010zfj.1_Missense_Mutation_p.V16957I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24381							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACCTATGACGGGGCTTCCA	0.443													T	179432795	T	T	179432795	3	4	171	1	0	0	0	0	1	0	0	0	16732	536	19	1	30063	1	TTN	2	179432795	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08	152836459	179432795	63766578	8	12212											
OXSR1	9943	broad.mit.edu	37	chr3	38266149	38266149	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaaaatatggaaaatcaTttagaaaaatgatttcattg	6	2	2	3			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr3:38266149T>C	uc003chy.2	+	8	1132	c.790T>C	c.(790-792)TTT>CTT	p.F264L	OXSR1_uc010hhb.2_Missense_Mutation_p.F198L|OXSR1_uc010hha.1_Missense_Mutation_p.F196L	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	264	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TGGAAAATCATTTAGAAAAAT	0.313													C	38266149	C	C	38266149	3	2	171	1	0	0	0	0	1	0	0	0	11336	1493	52	4	820	4	OXSR1	3	38266149	Missense_Mutation	SNP	T	TCGA-19-5960-01A-11D-1696-08		38266149	159756281	9	12213											
TRAK1	22906	broad.mit.edu	37	chr3	42242442	42242442	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactccctcctgtccagctgCgtcagcaccccccggtccag	8	20	1	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr3:42242442C>T	uc003cky.2	+	12	1539	c.1323C>T	c.(1321-1323)TGC>TGT	p.C441C	TRAK1_uc011azh.1_Silent_p.C441C|TRAK1_uc011azi.1_Silent_p.C441C|TRAK1_uc003ckz.3_Silent_p.C367C|TRAK1_uc011azj.1_Silent_p.C367C|TRAK1_uc003cla.2_Silent_p.C383C	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	441	Interaction with HGS.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TGTCCAGCTGCGTCAGCACCC	0.582													T	42242442	T	T	42242442	2	4	171	1	0	0	0	0	0	0	0	1	16446	776	27	1		1	TRAK1	3	42242442	Silent	SNP	C	TCGA-19-5960-01A-11D-1696-08	3976293	42242442	155779988	10	12214											
CASR	846	broad.mit.edu	37	chr3	122003250	122003250	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatgctcatcttcttcatcGtctggatctccttcattcca	5	14	7	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr3:122003250G>A	uc003eev.3	+	7	2821	c.2449G>A	c.(2449-2451)GTC>ATC	p.V817I	CASR_uc003eew.3_Missense_Mutation_p.V827I	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	817	Helical; Name=6; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CTTCTTCATCGTCTGGATCTC	0.527													A	122003250	A	A	122003250	3	1	171	1	0	0	0	0	1	0	0	0	2682	1145	40	1	2501	1	CASR	3	122003250	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	79760808	122003250	76019180	11	12215											
COL6A6	131873	broad.mit.edu	37	chr3	130313143	130313143	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agggaagcccagggaagagaGggactcctggtgaccgtgga	18	8	0	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr3:130313143G>C	uc010htl.2	+	17	4520	c.4489G>C	c.(4489-4491)GGG>CGG	p.G1497R	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1497	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AGGGAAGAGAGGGACTCCTGG	0.463													C	130313143	C	C	130313143	3	2	171	1	0	0	0	0	1	0	0	0	3703	1000	35	5	4555	5	COL6A6	3	130313143	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	8309893	130313143	67709287	12	12216											
TP63	8626	broad.mit.edu	37	chr3	189587160	189587160	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatgacatccatcaagaaaCgaagatccccagatgatgaa	8	9	1	7			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr3:189587160C>T	uc003fry.2	+	9	1266	c.1177C>T	c.(1177-1179)CGA>TGA	p.R393*	TP63_uc003frx.2_Nonsense_Mutation_p.R393*|TP63_uc003frz.2_Nonsense_Mutation_p.R393*|TP63_uc010hzc.1_Nonsense_Mutation_p.R393*|TP63_uc003fsa.2_Nonsense_Mutation_p.R299*|TP63_uc003fsb.2_Nonsense_Mutation_p.R299*|TP63_uc003fsc.2_Nonsense_Mutation_p.R299*|TP63_uc003fsd.2_Nonsense_Mutation_p.R299*|TP63_uc010hzd.1_Nonsense_Mutation_p.R214*|TP63_uc003fse.1_Nonsense_Mutation_p.R270*	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	393					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CATCAAGAAACGAAGATCCCC	0.413									Hay-Wells_syndrome	HNSCC(45;0.13)			T	189587160	T	T	189587160	4	4	171	1	0	0	0	0	0	1	0	0	16389	528	19	1	1257	1	TP63	3	189587160	Nonsense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08	59274017	189587160	8435270	13	12217											
FYTTD1	84248	broad.mit.edu	37	chr3	197497100	197497100	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agcagttctcaagagacctaGccagctaagcagaaagtaag	10	9	1	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr3:197497100G>T	uc003fyi.2	+	4	701	c.482G>T	c.(481-483)AGC>ATC	p.S161I	FYTTD1_uc011bui.1_Missense_Mutation_p.S135I|FYTTD1_uc011buj.1_Intron|FYTTD1_uc011buk.1_Missense_Mutation_p.S94I	NM_032288	NP_115664	Q96QD9	UIF_HUMAN	forty-two-three domain containing 1 isoform 1	161					mRNA export from nucleus	nuclear speck	mRNA binding|protein binding				0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.175)		AAGAGACCTAGCCAGCTAAGC	0.363													T	197497100	T	T	197497100	3	4	171	1	0	0	0	0	1	0	0	0	6127	971	34	5	525	5	FYTTD1	3	197497100	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	7909940	197497100	525330	14	12218											
EGF	1950	broad.mit.edu	37	chr4	110895931	110895931	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	actaaggagaacatctctcaAccacgaggaattgctgttca	8	10	3	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr4:110895931A>T	uc003hzy.3	+	12	2249	c.1797A>T	c.(1795-1797)CAA>CAT	p.Q599H	EGF_uc011cfu.1_Missense_Mutation_p.Q557H|EGF_uc011cfv.1_Missense_Mutation_p.Q599H	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	599	LDL-receptor class B 7.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ACATCTCTCAACCACGAGGAA	0.388													T	110895931	T	T	110895931	3	4	171	1	0	0	0	0	1	0	0	0	4962	40	2	5	1843	5	EGF	4	110895931	Missense_Mutation	SNP	A	TCGA-19-5960-01A-11D-1696-08		110895931	80258345	15	12219											
C6	729	broad.mit.edu	37	chr5	41196027	41196027	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcattctaactttctggcaaTgcagcggcctagtcaagaaa	9	10	3	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr5:41196027T>C	uc003jmk.2	-	5	664	c.454A>G	c.(454-456)ATT>GTT	p.I152V	C6_uc003jml.1_Missense_Mutation_p.I152V	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	152	LDL-receptor class A.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTTCTGGCAATGCAGCGGCCT	0.358													C	41196027	C	C	41196027	3	2	171	1	0	0	0	0	1	0	0	0	2315	1464	51	4	2406	4	C6	5	41196027	Missense_Mutation	SNP	T	TCGA-19-5960-01A-11D-1696-08		41196027	139719233	16	12220											
C5orf34	375444	broad.mit.edu	37	chr5	43487196	43487196	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agaaatctggtttaggatacCactattttctagtagcacta	7	7	2	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr5:43487196C>A	uc003jnz.1	-	14	2055	c.1738G>T	c.(1738-1740)GGT>TGT	p.G580C		NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	580										breast(1)	1	Lung NSC(6;2.07e-05)					TTTAGGATACCACTATTTTCT	0.313													A	43487196	A	A	43487196	3	1	171	1	0	0	0	0	1	0	0	0	2293	594	21	5	182	5	C5orf34	5	43487196	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08	2291169	43487196	137428064	17	12221											
FGFR4	2264	broad.mit.edu	37	chr5	176519769	176519769	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctcctaccagtctgcctgGctcacggtgctgccaggtga	11	15	3	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr5:176519769G>A	uc003mfl.2	+	8	1208	c.1041G>A	c.(1039-1041)TGG>TGA	p.W347*	FGFR4_uc003mfm.2_Nonsense_Mutation_p.W347*|FGFR4_uc011dfu.1_Nonsense_Mutation_p.W347*|FGFR4_uc011dfw.1_Nonsense_Mutation_p.W347*|FGFR4_uc003mfo.2_Nonsense_Mutation_p.W347*	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	347	Extracellular (Potential).|Ig-like C2-type 3.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	AGTCTGCCTGGCTCACGGTGC	0.647										TSP Lung(9;0.080)			A	176519769	A	A	176519769	4	1	171	1	0	0	0	0	0	1	0	0	5868	1212	42	3	1067	3	FGFR4	5	176519769	Nonsense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	133032573	176519769	4395491	18	12222											
TMEM217	221468	broad.mit.edu	37	chr6	37186701	37186701	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaactgccattccctaggtGcttctgttcaaagatgagat	9	10	2	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr6:37186701G>T	uc003onl.2	-	2	187	c.106C>A	c.(106-108)CAC>AAC	p.H36N	TMEM217_uc010jwr.2_Missense_Mutation_p.H36N|TMEM217_uc010jws.2_Intron|TMEM217_uc003onm.3_Missense_Mutation_p.H36N	NM_145316	NP_660359	Q8N7C4	TM217_HUMAN	transmembrane protein 217 isoform 1	36						integral to membrane					0						TTCCCTAGGTGCTTCTGTTCA	0.468													T	37186701	T	T	37186701	3	4	171	1	0	0	0	0	1	0	0	0	16137	1319	46	5	595	5	TMEM217	6	37186701	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		37186701	133928366	19	12223											
DNAH8	1769	broad.mit.edu	37	chr6	38830180	38830180	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttgggaaaatatgtggtcGtgttcaattgctcagatcaa	11	5	3	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr6:38830180G>A	uc003ooe.1	+	42	6205	c.5605G>A	c.(5605-5607)GTG>ATG	p.V1869M		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATATGTGGTCGTGTTCAATTG	0.418													A	38830180	A	A	38830180	3	1	171	1	0	0	0	0	1	0	0	0	4607	1145	40	1	5763	1	DNAH8	6	38830180	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	1643479	38830180	132284887	20	12224											
LRFN2	57497	broad.mit.edu	37	chr6	40400626	40400626	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtcaggtccaccagccccGtcatgttggcaaagtcctgg	13	13	2	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr6:40400626G>A	uc003oph.1	-	2	692	c.227C>T	c.(226-228)ACG>ATG	p.T76M		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	76	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					CACCAGCCCCGTCATGTTGGC	0.597													A	40400626	A	A	40400626	3	1	171	1	0	0	0	0	1	0	0	0	8938	1145	40	1	2150	1	LRFN2	6	40400626	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	1570446	40400626	130714441	21	12225											
TBP	6908	broad.mit.edu	37	chr6	170880497	170880497	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttttgcaattttccttctaGttatgagccagagttatttc	6	7	1	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr6:170880497G>A	uc003qxt.2	+	7	1078	c.846_splice	c.e7-1	p.S282_splice	TBP_uc003qxu.2_Splice_Site_p.S282_splice|TBP_uc011ehf.1_Splice_Site_p.S262_splice	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein						cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		TTTCCTTCTAGTTATGAGCCA	0.318													A	170880497	A	A	170880497	5	1	171	1	0	0	0	0	0	0	1	0	15641	1043	36	3	867	3	TBP	6	170880497	Splice_Site	SNP	G	TCGA-19-5960-01A-11D-1696-08	130479871	170880497	234570	22	12226											
TECPR1	25851	broad.mit.edu	37	chr7	97862242	97862242	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaggcagcggtctgggccGgcgtgatggacagggacagc	18	11	1	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr7:97862242G>A	uc003upg.2	-	12	1920	c.1715C>T	c.(1714-1716)CCG>CTG	p.P572L	TECPR1_uc003uph.1_Missense_Mutation_p.P502L	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	572						integral to membrane	protein binding			pancreas(1)	1						GGTCTGGGCCGGCGTGATGGA	0.652													A	97862242	A	A	97862242	3	1	171	1	0	0	0	0	1	0	0	0	15740	1116	39	2	1842	2	TECPR1	7	97862242	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		97862242	61276421	23	12227											
CYP3A5	1577	broad.mit.edu	37	chr7	99264589	99264589	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatacctccttgagttttcCgctggtgaaggttggagaca	11	9	1	3			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr7:99264589C>T	uc003urq.2	-	5	505	c.418G>A	c.(418-420)GGA>AGA	p.G140R	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_5'UTR|CYP3A5_uc003urr.2_Missense_Mutation_p.G27R|CYP3A5_uc011kiy.1_Missense_Mutation_p.G130R|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	140					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	TTGAGTTTTCCGCTGGTGAAG	0.413													T	99264589	T	T	99264589	3	4	171	1	0	0	0	0	1	0	0	0	4180	661	23	2	1126	2	CYP3A5	7	99264589	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08	1402347	99264589	59874074	24	12228											
KIAA1147	57189	broad.mit.edu	37	chr7	141365018	141365018	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gacacctctacctccaggctCtcgatgtcagccacgttcac	7	17	4	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr7:141365018C>G	uc003vwk.2	-	6	921	c.921G>C	c.(919-921)GAG>GAC	p.E307D		NM_001080392	NP_001073861	A4D1U4	LCHN_HUMAN	hypothetical protein LOC57189	307										ovary(1)	1	Melanoma(164;0.0171)					CCTCCAGGCTCTCGATGTCAG	0.602													G	141365018	G	G	141365018	3	3	171	1	0	0	0	0	1	0	0	0	8210	912	32	5	462	5	KIAA1147	7	141365018	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08	42100429	141365018	17773645	25	12229											
NOS3	4846	broad.mit.edu	37	chr7	150695737	150695737	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcaggatggctctgtgcGgggggacccagccaacgtgg	18	11	1	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr7:150695737G>A	uc003wif.2	+	7	1081	c.785G>A	c.(784-786)CGG>CAG	p.R262Q	NOS3_uc011kuy.1_Missense_Mutation_p.R56Q|NOS3_uc011kuz.1_Missense_Mutation_p.R262Q|NOS3_uc011kva.1_Missense_Mutation_p.R262Q|NOS3_uc011kvb.1_Missense_Mutation_p.R262Q	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	262	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GGCTCTGTGCGGGGGGACCCA	0.652													A	150695737	A	A	150695737	3	1	171	1	0	0	0	0	1	0	0	0	10544	1116	39	2	807	2	NOS3	7	150695737	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	9330719	150695737	8442926	26	12230											
IMPAD1	54928	broad.mit.edu	37	chr8	57905955	57905955	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacacagccagcatctcgcGcaagtccacggtgcccccat	9	17	1	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr8:57905955G>A	uc003xte.3	-	1	473	c.190C>T	c.(190-192)CGC>TGC	p.R64C		NM_017813	NP_060283	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	64						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			ovary(1)	1		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				AGCATCTCGCGCAAGTCCACG	0.572													A	57905955	A	A	57905955	3	1	171	1	0	0	0	0	1	0	0	0	7725	1087	38	1	909	1	IMPAD1	8	57905955	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		57905955	88458067	27	12231											
TPD52	7163	broad.mit.edu	37	chr8	80954870	80954870	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgcctttaagttttcgacCttttcttcaaatgatttaaa	4	8	2	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr8:80954870C>T	uc003ybr.1	-	5	862	c.540G>A	c.(538-540)AAG>AAA	p.K180K	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_RNA|TPD52_uc003ybs.1_Silent_p.K163K|TPD52_uc003ybt.1_Silent_p.K140K|TPD52_uc003ybq.1_RNA|TPD52_uc003ybu.1_RNA	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	180					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			AGTTTTCGACCTTTTCTTCAA	0.308													T	80954870	T	T	80954870	2	4	171	1	0	0	0	0	0	0	0	1	16394	680	24	3		3	TPD52	8	80954870	Silent	SNP	C	TCGA-19-5960-01A-11D-1696-08	23048915	80954870	65409152	28	12232											
FBP1	2203	broad.mit.edu	37	chr9	97401548	97401548	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccctcctccatgacgaagcgGgtcagggtgttgacgtccgt	13	13	1	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr9:97401548G>C	uc004auw.3	-	1	376	c.45C>G	c.(43-45)ACC>ACG	p.T15T	FBP1_uc010mrl.2_Silent_p.T15T	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	15					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	TGACGAAGCGGGTCAGGGTGT	0.667													C	97401548	C	C	97401548	2	2	171	1	0	0	0	0	0	0	0	1	5705	1219	43	5		5	FBP1	9	97401548	Silent	SNP	G	TCGA-19-5960-01A-11D-1696-08		97401548	43811883	29	12233											
TRAF2	7186	broad.mit.edu	37	chr9	139818449	139818449	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctgcggtggcccttcaaccaGaaggtgaggccgtccctgca	13	14	1	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr9:139818449G>A	uc010nbu.2	+	11	1457	c.1284G>A	c.(1282-1284)CAG>CAA	p.Q428Q	TRAF2_uc004cjv.2_Silent_p.Q428Q|TRAF2_uc011mek.1_Silent_p.Q417Q|TRAF2_uc010nbw.2_Silent_p.Q403Q	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	428	MATH.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		CCTTCAACCAGAAGGTGAGGC	0.647													A	139818449	A	A	139818449	2	1	171	1	0	0	0	0	0	0	0	1	16435	933	33	3		3	TRAF2	9	139818449	Silent	SNP	G	TCGA-19-5960-01A-11D-1696-08	42416901	139818449	1394982	30	12234											
CAMK1D	57118	broad.mit.edu	37	chr10	12802954	12802954	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttttttgccagggtgtccGgtggagagctgtttgaccgg	15	8	1	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr10:12802954G>A	uc001ilo.2	+	4	542	c.307G>A	c.(307-309)GGT>AGT	p.G103S	CAMK1D_uc001iln.2_Missense_Mutation_p.G103S	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	103	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		CAGGGTGTCCGGTGGAGAGCT	0.443													A	12802954	A	A	12802954	3	1	171	1	0	0	0	0	1	0	0	0	2597	1116	39	2	321	2	CAMK1D	10	12802954	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		12802954	122731793	31	12235											
C10orf76	79591	broad.mit.edu	37	chr10	103716424	103716424	+	Frame_Shift_Del	DEL	G	-	-													taaagttcatcatagctgctGggggttggcagaaatgtgtc							TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr10:103716424delG	uc009xwy.1	-	22	1737	c.1635delC	c.(1633-1635)CCCfs	p.P545fs	C10orf76_uc009xwx.1_RNA	NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	545						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		CATAGCTGCTGGGGGTTGGCA	0.408													-	103716424	-	-	103716424	7	5	171	1	0	1	0	1	0	0	0	0	1616	1335	47	0	454	0	C10orf76	10	103716424	Frame_Shift_Del	DEL	G	TCGA-19-5960-01A-11D-1696-08	90913470	103716424	31818323	32	12236											
OR52M1	119772	broad.mit.edu	37	chr11	4566796	4566796	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatggcttttgatcgctacGtggccatctgcaacccacta	8	14	1	1	rs61751910	byFrequency	TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr11:4566796G>A	uc010qyf.1	+	1	376	c.376G>A	c.(376-378)GTG>ATG	p.V126M		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGATCGCTACGTGGCCATCTG	0.527													A	4566796	A	A	4566796	3	1	171	1	0	0	0	0	1	0	0	0	11126	1145	40	1	378	1	OR52M1	11	4566796	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		4566796	130439720	33	12237											
GLYAT	10249	broad.mit.edu	37	chr11	58478160	58478160	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgccatatagagaatgcGttgtgtttgtttgactttga	11	5	0	3			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr11:58478160G>A	uc001nnb.2	-	5	546	c.391C>T	c.(391-393)CGC>TGC	p.R131C	GLYAT_uc001nnc.2_Missense_Mutation_p.R131C	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	131					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TAGAGAATGCGTTGTGTTTGT	0.428													A	58478160	A	A	58478160	3	1	171	1	0	0	0	0	1	0	0	0	6479	1145	40	1	511	1	GLYAT	11	58478160	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	53911364	58478160	76528356	34	12238											
GPR83	10888	broad.mit.edu	37	chr11	94113665	94113665	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggaggacgtagcagttgaGggggaaccagcagagggcaa	19	6	0	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr11:94113665G>A	uc001pet.2	-	4	1094	c.922C>T	c.(922-924)CTC>TTC	p.L308F		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	308	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TAGCAGTTGAGGGGGAACCAG	0.532													A	94113665	A	A	94113665	3	1	171	1	0	0	0	0	1	0	0	0	6713	1000	35	3	353	3	GPR83	11	94113665	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	35635505	94113665	40892851	35	12239											
MPZL2	10205	broad.mit.edu	37	chr11	118133277	118133277	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagaaggatggaggcatcGtaccgctcaggattcccatc	12	11	1	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr11:118133277G>A	uc001psn.2	-	3	453	c.312C>T	c.(310-312)TAC>TAT	p.Y104Y	MPZL2_uc001pso.2_Silent_p.Y104Y|MPZL2_uc001psp.1_Silent_p.Y104Y	NM_005797	NP_005788	O60487	MPZL2_HUMAN	myelin protein zero-like 2 precursor	104	Extracellular (Potential).|Ig-like V-type.				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				skin(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		TGGAGGCATCGTACCGCTCAG	0.527													A	118133277	A	A	118133277	2	1	171	1	0	0	0	0	0	0	0	1	9750	1140	40	1		1	MPZL2	11	118133277	Silent	SNP	G	TCGA-19-5960-01A-11D-1696-08	24019612	118133277	16873239	36	12240											
FLI1	2313	broad.mit.edu	37	chr11	128680531	128680531	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	catgaattacgacaagctgaGccgggccctccgttattact	9	12	0	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr11:128680531G>T	uc010sbu.1	+	9	1348	c.1007G>T	c.(1006-1008)AGC>ATC	p.S336I	FLI1_uc010sbt.1_Missense_Mutation_p.S143I|FLI1_uc010sbv.1_Missense_Mutation_p.S303I|FLI1_uc009zci.2_Missense_Mutation_p.S270I	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	336	ETS.				hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GACAAGCTGAGCCGGGCCCTC	0.522			T	EWSR1	Ewing sarcoma								T	128680531	T	T	128680531	3	4	171	1	0	0	0	0	1	0	0	0	5924	971	34	5	1041	5	FLI1	11	128680531	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08	10547254	128680531	6325985	37	12241											
RASSF9	9182	broad.mit.edu	37	chr12	86199652	86199652	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacatcagcagaggtggtgcGtttagtcagcccacagacaa	12	10	2	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr12:86199652G>A	uc001taf.1	-	2	475	c.136C>T	c.(136-138)CGC>TGC	p.R46C		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	46	Ras-associating.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						GAGGTGGTGCGTTTAGTCAGC	0.453													A	86199652	A	A	86199652	3	1	171	1	0	0	0	0	1	0	0	0	13093	1145	40	1	1175	1	RASSF9	12	86199652	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		86199652	47652243	38	12242											
DCLK1	9201	broad.mit.edu	37	chr13	36700120	36700120	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ctttcttggccttcttctcgGagctgagcgtctgcagcgtg	12	12	4	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr13:36700120G>T	uc001uvf.2	-	2	388	c.155C>A	c.(154-156)TCC>TAC	p.S52Y		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	52					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CTTCTTCTCGGAGCTGAGCGT	0.582													T	36700120	T	T	36700120	3	4	171	1	0	0	0	0	1	0	0	0	4291	1174	41	5	2102	5	DCLK1	13	36700120	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		36700120	78469758	39	12243											
SLITRK5	26050	broad.mit.edu	37	chr13	88329407	88329407	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagtgggcgtcctagtggaCgaggtgatctgtaaggcgcc	16	8	1	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr13:88329407C>T	uc001vln.2	+	2	1983	c.1764C>T	c.(1762-1764)GAC>GAT	p.D588D	SLITRK5_uc010tic.1_Silent_p.D347D	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	588	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TCCTAGTGGACGAGGTGATCT	0.512													T	88329407	T	T	88329407	2	4	171	1	0	0	0	0	0	0	0	1	14746	535	19	1		1	SLITRK5	13	88329407	Silent	SNP	C	TCGA-19-5960-01A-11D-1696-08	51629287	88329407	26840471	40	12244											
CLYBL	171425	broad.mit.edu	37	chr13	100515267	100515267	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcagacaaattttcattccActtaaaaggccgaaaacttg	6	9	1	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr13:100515267A>G	uc001vok.2	+	4	475	c.461A>G	c.(460-462)CAC>CGC	p.H154R	CLYBL_uc010tix.1_Missense_Mutation_p.H154R|CLYBL_uc010tiy.1_Intron	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	154					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTTTCATTCCACTTAAAAGGC	0.358													G	100515267	G	G	100515267	3	3	171	1	0	0	0	0	1	0	0	0	3573	159	6	4	475	4	CLYBL	13	100515267	Missense_Mutation	SNP	A	TCGA-19-5960-01A-11D-1696-08	12185860	100515267	14654611	41	12245											
TEKT5	146279	broad.mit.edu	37	chr16	10783110	10783110	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaaaaaaaaagcccttacCgcatctggatatcaattctt	4	9	3	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr16:10783110C>T	uc002czz.1	-	3	791	c.719G>A	c.(718-720)CGG>CAG	p.R240Q		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	240	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						AAGCCCTTACCGCATCTGGAT	0.413													T	10783110	T	T	10783110	3	4	171	1	0	0	0	0	1	0	0	0	15753	666	23	2	758	2	TEKT5	16	10783110	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08		10783110	79571643	42	12246											
RECQL5	9400	broad.mit.edu	37	chr17	73625102	73625102	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcccctgtgtacttctctgGggccatcgggggtccctgaa	12	14	1	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr17:73625102G>A	uc010dgl.2	-	16	2557	c.2401C>T	c.(2401-2403)CCA>TCA	p.P801S	RECQL5_uc010dgk.2_Missense_Mutation_p.P774S|RECQL5_uc002jot.3_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	801					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TACTTCTCTGGGGCCATCGGG	0.647								Other_identified_genes_with_known_or_suspected_DNA_repair_function					A	73625102	A	A	73625102	3	1	171	1	0	0	0	0	1	0	0	0	13203	1232	43	3	594	3	RECQL5	17	73625102	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		73625102	7570108	43	12247											
TNFRSF11A	8792	broad.mit.edu	37	chr18	60036664	60036664	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggaggctcccaagctcagCgagggcaggtgccgggtctg	18	11	2	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr18:60036664C>T	uc002lin.2	+	9	1552	c.1514C>T	c.(1513-1515)GCG>GTG	p.A505V	TNFRSF11A_uc010dpv.2_Intron	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	505	Cytoplasmic (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				CCAAGCTCAGCGAGGGCAGGT	0.632									Paget_Disease_of_Bone				T	60036664	T	T	60036664	3	4	171	1	0	0	0	0	1	0	0	0	16281	768	27	1	1548	1	TNFRSF11A	18	60036664	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08		60036664	18040584	44	12248											
CREB3L3	84699	broad.mit.edu	37	chr19	4171806	4171806	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggggcttccaggacaccgCgaacctgaccaattcgacgg	12	14	0	1	rs148141076		TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr19:4171806C>T	uc002lzl.2	+	10	1342	c.1226C>T	c.(1225-1227)GCG>GTG	p.A409V	CREB3L3_uc002lzm.2_Missense_Mutation_p.A399V|CREB3L3_uc010xib.1_Missense_Mutation_p.A398V|CREB3L3_uc010xic.1_3'UTR	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	409	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGACACCGCGAACCTGACC	0.677													T	4171806	T	T	4171806	3	4	171	1	0	0	0	0	1	0	0	0	3858	768	27	1	1264	1	CREB3L3	19	4171806	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08		4171806	54957177	45	12249											
LILRA6	79168	broad.mit.edu	37	chr19	54744788	54744788	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accatagcacctgtactggcCcccgtgggaggggctcacag	13	14	1	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr19:54744788C>T	uc002qeu.1	-	5	998	c.874G>A	c.(874-876)GGC>AGC	p.G292S	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Missense_Mutation_p.G292S|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.G292S|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.G292S|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.G292S|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Missense_Mutation_p.G292S|LILRA6_uc010yeq.1_Missense_Mutation_p.G292S|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.G153S	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	292	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGTACTGGCCCCCGTGGGAG	0.682													T	54744788	T	T	54744788	3	4	171	1	0	0	0	0	1	0	0	0	8789	623	22	3	587	3	LILRA6	19	54744788	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08	50572982	54744788	4384195	46	12250											
ADNP	23394	broad.mit.edu	37	chr20	49508976	49508976	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttcataggaatcatcttcatGacccttggggtctaaagcta	8	9	5	1			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr20:49508976G>T	uc002xvt.1	-	5	2620	c.2275C>A	c.(2275-2277)CAT>AAT	p.H759N	ADNP_uc002xvu.1_Missense_Mutation_p.H759N	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	759	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TCATCTTCATGACCCTTGGGG	0.418													T	49508976	T	T	49508976	3	4	171	1	0	0	0	0	1	0	0	0	323	1290	45	5	1037	5	ADNP	20	49508976	Missense_Mutation	SNP	G	TCGA-19-5960-01A-11D-1696-08		49508976	13516544	47	12251											
ATP9A	10079	broad.mit.edu	37	chr20	50313988	50313988	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caacgatgataaggtctccaActtggatgttagaactcttc	8	9	2	2			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr20:50313988A>G	uc002xwg.1	-	5	470	c.470T>C	c.(469-471)GTT>GCT	p.V157A	ATP9A_uc010gih.1_Intron|ATP9A_uc002xwf.1_5'UTR	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	157	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						AAGGTCTCCAACTTGGATGTT	0.418													G	50313988	G	G	50313988	3	3	171	1	0	0	0	0	1	0	0	0	1198	43	2	4	2769	4	ATP9A	20	50313988	Missense_Mutation	SNP	A	TCGA-19-5960-01A-11D-1696-08	805012	50313988	12711532	48	12252											
RCAN1	1827	broad.mit.edu	37	chr21	35890504	35890504	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcactctcacatacatggaCcaccacgctgggagtggtgt	10	12	2	0			TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr21:35890504C>T	uc002yue.2	-	4	709	c.637G>A	c.(637-639)GTC>ATC	p.V213I	RCAN1_uc002yuc.2_Missense_Mutation_p.V132I|RCAN1_uc002yud.2_Missense_Mutation_p.V78I|RCAN1_uc002yub.2_Missense_Mutation_p.V158I	NM_004414	NP_004405	P53805	RCAN1_HUMAN	calcipressin 1 isoform a	213					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						CATACATGGACCACCACGCTG	0.493													T	35890504	T	T	35890504	3	4	171	1	0	0	0	0	1	0	0	0	13168	507	18	3	125	3	RCAN1	21	35890504	Missense_Mutation	SNP	C	TCGA-19-5960-01A-11D-1696-08		35890504	12239391	49	12253											
ZDHHC8	29801	broad.mit.edu	37	chr22	20131184	20131184	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagggcctgccctccccgccCggcactccccactcaccatc	7	24	1	0	rs34918643		TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chr22:20131184C>T	uc002zrq.2	+	10	2137	c.2031C>T	c.(2029-2031)CCC>CCT	p.P677P	ZDHHC8_uc002zrr.1_Silent_p.P677P|ZDHHC8_uc010gsa.2_Silent_p.P483P	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	677	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					CCTCCCCGCCCGGCACTCCCC	0.716													T	20131184	T	T	20131184	2	4	171	1	0	0	0	0	0	0	0	1	17618	639	23	2		2	ZDHHC8	22	20131184	Silent	SNP	C	TCGA-19-5960-01A-11D-1696-08		20131184	31173382	50	12254											
PCDH19	57526	broad.mit.edu	37	chrX	99663560	99663562	+	In_Frame_Del	DEL	CAG	-	-													gcctgcgtccacagtatggcCagcagcagcagcaccggcag							TCGA-19-5960-01A-11D-1696-08	TCGA-19-5960-11A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8151614-b08f-49a3-ab6f-2e780f765a17	6550b1a6-606e-478b-8332-3836c47a6b84	g.chrX:99663560_99663562delCAG	uc010nmz.2	-	1	1710_1712	c.34_36delCTG	c.(34-36)CTGdel	p.L12del	PCDH19_uc004efw.3_In_Frame_Del_p.L12del|PCDH19_uc004efx.3_In_Frame_Del_p.L12del	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	12					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						ACAGTATGGCCAGCAGCAGCAGC	0.665													-	99663562	-	-	99663560	7	5	171	1	0	1	0	1	0	0	0	0	11514	581	21	0	3434	0	PCDH19	23	99663560	In_Frame_Del	DEL	CAG	TCGA-19-5960-01A-11D-1696-08		99663560	55607000	51	12255											
TTLL10	254173	broad.mit.edu	37	chr1	1120451	1120451	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgacacgttctggaaggccCggggcctcgccaaggactgg	16	12	1	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr1:1120451C>T	uc001acy.2	+	13	1514	c.1363C>T	c.(1363-1365)CGG>TGG	p.R455W	TTLL10_uc010nyg.1_Missense_Mutation_p.R455W|TTLL10_uc001acz.1_Missense_Mutation_p.R382W	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	455	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CTGGAAGGCCCGGGGCCTCGC	0.612													T	1120451	T	T	1120451	3	4	172	1	0	0	0	0	1	0	0	0	16720	643	23	2	1401	2	TTLL10	1	1120451	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08		1120451	248130170	1	12256											
ADC	113451	broad.mit.edu	37	chr1	33583680	33583681	+	Frame_Shift_Ins	INS	-	C	C													ccccttttgggggacccaggINScctgccacatcacctatgcc							TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr1:33583680_33583681insC	uc001bwr.2	+	11	1794_1795	c.1207_1208insC	c.(1207-1209)GCCfs	p.A403fs	ADC_uc001bws.2_Frame_Shift_Ins_p.A403fs|ADC_uc009vue.2_Frame_Shift_Ins_p.A403fs|ADC_uc001bwt.1_Frame_Shift_Ins_p.A308fs|ADC_uc001bwu.2_Frame_Shift_Ins_p.A308fs|ADC_uc001bwv.2_Frame_Shift_Ins_p.A308fs|ADC_uc001bww.2_Frame_Shift_Ins_p.A308fs|ADC_uc001bwx.1_Frame_Shift_Ins_p.A380fs|ADC_uc009vug.2_Frame_Shift_Ins_p.A423fs	NM_052998	NP_443724	Q96A70	ADC_HUMAN	ODC antizyme inhibitor-2	403					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	GGGGACCCAGGCCTGCCACATC	0.614													C	33583681	C	C	33583680	7	5	172	1	0	1	1	0	0	0	0	0	287	1203	42	0	1237	0	ADC	1	33583680	Frame_Shift_Ins	INS	-	TCGA-26-1439-01A-01D-1353-08	32463229	33583680	215666941	2	12257											
TCHH	7062	broad.mit.edu	37	chr1	152081494	152081494	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgctcgcgctcctggcagCgcagctgctgttcctcctta	11	15	0	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr1:152081494C>T	uc001ezp.2	-	2	4199	c.4199G>A	c.(4198-4200)CGC>CAC	p.R1400H	TCHH_uc009wne.1_Missense_Mutation_p.R1400H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1400	23 X 26 AA approximate tandem repeats.		R -> P (found in a renal cell carcinoma sample; somatic mutation).		keratinization	cytoskeleton	calcium ion binding	p.R1400P(1)		ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCCTGGCAGCGCAGCTGCTG	0.587													T	152081494	T	T	152081494	3	4	172	1	0	0	0	0	1	0	0	0	15697	768	27	1	1636	1	TCHH	1	152081494	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08	118497814	152081494	97169127	3	12258											
PCP4L1	654790	broad.mit.edu	37	chr1	161253488	161253488	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacatccccagcaaccaacCaggcagctggccaagaggaa	9	14	0	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr1:161253488C>T	uc001gad.2	+	2	288	c.40C>T	c.(40-42)CAG>TAG	p.Q14*		NM_001102566	NP_001096036	A6NKN8	PC4L1_HUMAN	Purkinje cell protein 4 like 1	14											0	all_cancers(52;4.16e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGCAACCAACCAGGCAGCTGG	0.428													T	161253488	T	T	161253488	4	4	172	1	0	0	0	0	0	1	0	0	11599	595	21	3	46	3	PCP4L1	1	161253488	Nonsense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08	9171994	161253488	87997133	4	12259											
NMNAT2	23057	broad.mit.edu	37	chr1	183261948	183261948	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccaatcagaattctggacGgccagctgacacatgatgag	10	10	2	4	rs138225647		TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr1:183261948G>A	uc001gqc.1	-	3	554	c.219C>T	c.(217-219)GCC>GCT	p.A73A	NMNAT2_uc001gqb.1_Silent_p.A68A|NMNAT2_uc001gqd.2_5'Flank	NM_015039	NP_055854	Q9BZQ4	NMNA2_HUMAN	nicotinamide mononucleotide adenylyltransferase	73					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			skin(1)	1						AATTCTGGACGGCCAGCTGAC	0.562													A	183261948	A	A	183261948	2	1	172	1	0	0	0	0	0	0	0	1	10499	1103	39	2		2	NMNAT2	1	183261948	Silent	SNP	G	TCGA-26-1439-01A-01D-1353-08	22008460	183261948	65988673	5	12260											
MFSD2B	388931	broad.mit.edu	37	chr2	24247038	24247038	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctcaaagtcctcattggcGccgtgcccacctgcatgatc	8	17	2	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr2:24247038G>A	uc002reo.1	+	13	1401	c.1387G>A	c.(1387-1389)GCC>ACC	p.A463T		NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	463	Helical; (Potential).				transport	integral to membrane				ovary(2)	2						CCTCATTGGCGCCGTGCCCAC	0.607													A	24247038	A	A	24247038	3	1	172	1	0	0	0	0	1	0	0	0	9531	1087	38	1	1437	1	MFSD2B	2	24247038	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08		24247038	218952335	6	12261											
VAX2	25806	broad.mit.edu	37	chr2	71160172	71160172	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgctgtcctcggcctcagcGtcccccccactgccgccccc	8	25	1	0	rs144443163	byFrequency	TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr2:71160172G>A	uc002shh.2	+	3	743	c.711G>A	c.(709-711)GCG>GCA	p.A237A	ATP6V1B1_uc002shi.1_5'Flank|ATP6V1B1_uc002shj.2_5'Flank|ATP6V1B1_uc010fdv.2_5'Flank|ATP6V1B1_uc010fdw.2_5'Flank	NM_012476	NP_036608	Q9UIW0	VAX2_HUMAN	ventral anterior homeobox 2	237					ectoderm development|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGGCCTCAGCGTCCCCCCCAC	0.692													A	71160172	A	A	71160172	2	1	172	1	0	0	0	0	0	0	0	1	17132	1132	40	1		1	VAX2	2	71160172	Silent	SNP	G	TCGA-26-1439-01A-01D-1353-08	46913134	71160172	172039201	7	12262											
EXOC6B	23233	broad.mit.edu	37	chr2	72692422	72692422	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtaggaactggtcaatcttcTggtttaagttggtataaatc	10	5	3	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr2:72692422T>A	uc010fep.2	-	18	1985	c.1847A>T	c.(1846-1848)CAG>CTG	p.Q616L	EXOC6B_uc002sij.2_Missense_Mutation_p.Q616L	NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	616					protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						GTCAATCTTCTGGTTTAAGTT	0.393													A	72692422	A	A	72692422	3	1	172	1	0	0	0	0	1	0	0	0	5309	1580	55	5	608	5	EXOC6B	2	72692422	Missense_Mutation	SNP	T	TCGA-26-1439-01A-01D-1353-08	1532250	72692422	170506951	8	12263											
SUSD5	26032	broad.mit.edu	37	chr3	33194868	33194868	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgagggtgctactcttgggcTtcttaacttccacaagaatg	10	9	2	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr3:33194868T>C	uc003cfo.1	-	5	1674	c.1256A>G	c.(1255-1257)AAG>AGG	p.K419R		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	419	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						ACTCTTGGGCTTCTTAACTTC	0.517													C	33194868	C	C	33194868	3	2	172	1	0	0	0	0	1	0	0	0	15408	1609	56	4	637	4	SUSD5	3	33194868	Missense_Mutation	SNP	T	TCGA-26-1439-01A-01D-1353-08		33194868	164827562	9	12264											
SGEF	26084	broad.mit.edu	37	chr3	153867229	153867229	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gccaggaggaaagaaagagaCaagaggtatgtttctaccga	13	6	1	3			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr3:153867229C>G	uc011bog.1	+	5	1532	c.1321C>G	c.(1321-1323)CAA>GAA	p.Q441E	SGEF_uc011boh.1_Missense_Mutation_p.Q441E	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	441	DH.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AAGAAAGAGACAAGAGGTATG	0.393													G	153867229	G	G	153867229	3	3	172	1	0	0	0	0	1	0	0	0	14205	479	17	5	1335	5	SGEF	3	153867229	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08	120672361	153867229	44155201	10	12265											
DCHS2	54798	broad.mit.edu	37	chr4	155219800	155219800	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tttgctcccggtccaaagcaCgagtggttgagagttctcct	11	11	1	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr4:155219800C>G	uc003inw.2	-	18	4301	c.4301G>C	c.(4300-4302)CGT>CCT	p.R1434P		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1434	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GTCCAAAGCACGAGTGGTTGA	0.393													G	155219800	G	G	155219800	3	3	172	1	0	0	0	0	1	0	0	0	4288	536	19	5	4481	5	DCHS2	4	155219800	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08		155219800	35934476	11	12266											
DCHS2	54798	broad.mit.edu	37	chr4	155242236	155242236	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcaacaatactaaaatgtaActttccattataatgttgtt	4	6	0	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr4:155242236A>G	uc003inw.2	-	14	2950	c.2950T>C	c.(2950-2952)TTA>CTA	p.L984L		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	984	Cadherin 8.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTAAAATGTAACTTTCCATTA	0.328													G	155242236	G	G	155242236	2	3	172	1	0	0	0	0	0	0	0	1	4288	40	2	4		4	DCHS2	4	155242236	Silent	SNP	A	TCGA-26-1439-01A-01D-1353-08	22436	155242236	35912040	12	12267											
HEATR7B2	133558	broad.mit.edu	37	chr5	41058241	41058241	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggcccagggcgtatccaCggaagtcttcccgatgcagc	12	15	1	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr5:41058241C>T	uc003jmj.3	-	7	1170	c.680G>A	c.(679-681)CGT>CAT	p.R227H	HEATR7B2_uc003jmi.3_Translation_Start_Site	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	227							binding			ovary(6)|central_nervous_system(2)	8						GGCGTATCCACGGAAGTCTTC	0.517													T	41058241	T	T	41058241	3	4	172	1	0	0	0	0	1	0	0	0	7035	536	19	1	4221	1	HEATR7B2	5	41058241	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08		41058241	139857019	13	12268											
MAST4	375449	broad.mit.edu	37	chr5	66460510	66460510	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccccagcccaagtggtgacGtgagggcctctgtgccacca	13	15	1	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr5:66460510G>A	uc003jut.1	+	28	5004	c.4936G>A	c.(4936-4938)GTG>ATG	p.V1646M	MAST4_uc003juw.2_Missense_Mutation_p.V1574M|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1838						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AAGTGGTGACGTGAGGGCCTC	0.562													A	66460510	A	A	66460510	3	1	172	1	0	0	0	0	1	0	0	0	9327	1145	40	1	5747	1	MAST4	5	66460510	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	25402269	66460510	114454750	14	12269											
TRPC7	57113	broad.mit.edu	37	chr5	135692416	135692416	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgccagtcctttgtaggcGttcatgcgcgagcgcgagtg	14	12	1	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr5:135692416G>A	uc003lbn.1	-	1	660	c.657C>T	c.(655-657)AAC>AAT	p.N219N	TRPC7_uc010jef.1_Silent_p.N211N|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Silent_p.N211N|TRPC7_uc010jei.1_Silent_p.N211N|TRPC7_uc010jej.1_Translation_Start_Site	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	220	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTTTGTAGGCGTTCATGCGCG	0.607													A	135692416	A	A	135692416	2	1	172	1	0	0	0	0	0	0	0	1	16581	1136	40	1		1	TRPC7	5	135692416	Silent	SNP	G	TCGA-26-1439-01A-01D-1353-08	69231906	135692416	45222844	15	12270											
LRRTM2	26045	broad.mit.edu	37	chr5	138209080	138209081	+	Frame_Shift_Ins	INS	-	T	T													tttctttgtctcccacatggINStaacttgatgagcttattct							TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr5:138209080_138209081insT	uc011cyz.1	-	2	1626_1627	c.1169_1170insA	c.(1168-1170)TACfs	p.Y390fs	CTNNA1_uc003ldh.2_Intron|CTNNA1_uc011cyx.1_Intron|CTNNA1_uc011cyy.1_Intron|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Intron|LRRTM2_uc010jez.2_Intron|LRRTM2_uc011cza.1_Frame_Shift_Ins_p.Y256fs|CTNNA1_uc003ldl.2_5'Flank	NM_015564	NP_056379	O43300	LRRT2_HUMAN	leucine rich repeat transmembrane neuronal 2	390	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CTCCCACATGGTAACTTGATGA	0.431													T	138209081	T	T	138209080	7	5	172	1	0	1	1	0	0	0	0	0	9040	1256	44	0	384	0	LRRTM2	5	138209080	Frame_Shift_Ins	INS	-	TCGA-26-1439-01A-01D-1353-08	2516664	138209080	42706180	16	12271											
PCDHA9	9752	broad.mit.edu	37	chr5	140229393	140229393	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcgccttcactgtgggccaCggccagggtgtctgtggagg	16	12	2	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr5:140229393C>T	uc003lhu.2	+	1	2037	c.1313C>T	c.(1312-1314)ACG>ATG	p.T438M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.T438M	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	438	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTGGGCCACGGCCAGGGTG	0.657													T	140229393	T	T	140229393	3	4	172	1	0	0	0	0	1	0	0	0	11531	536	19	1	1315	1	PCDHA9	5	140229393	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08	2020313	140229393	40685867	17	12272											
RUNX2	860	broad.mit.edu	37	chr6	45390685	45390685	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaacaagaccctgcccgtGgccttcaaggtaagaggcta	11	12	1	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr6:45390685G>A	uc011dvx.1	+	3	624	c.414G>A	c.(412-414)GTG>GTA	p.V138V	RUNX2_uc011dvy.1_Silent_p.V138V|RUNX2_uc003oxt.2_Silent_p.V124V	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	138	Runt.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						CCCTGCCCGTGGCCTTCAAGG	0.577													A	45390685	A	A	45390685	2	1	172	1	0	0	0	0	0	0	0	1	13748	1335	47	3		3	RUNX2	6	45390685	Silent	SNP	G	TCGA-26-1439-01A-01D-1353-08		45390685	125724382	18	12273											
DBNL	28988	broad.mit.edu	37	chr7	44100419	44100419	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaccccgagaacctcatcacGggcatcgaggtgatcgacga	12	13	2	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr7:44100419G>T	uc003tjp.3	+	13	1295	c.1197G>T	c.(1195-1197)ACG>ACT	p.T399T	DBNL_uc003tjo.3_Silent_p.T400T|DBNL_uc003tjr.3_Silent_p.T272T|DBNL_uc003tjq.3_Silent_p.T408T|DBNL_uc011kbm.1_Silent_p.T375T|DBNL_uc011kbn.1_Silent_p.T296T|DBNL_uc011kbo.1_Silent_p.T300T|DBNL_uc011kbp.1_Silent_p.T351T|DBNL_uc011kbq.1_Silent_p.T324T|DBNL_uc011kbr.1_Silent_p.T348T|DBNL_uc011kbs.1_Silent_p.T304T	NM_001014436	NP_001014436	Q9UJU6	DBNL_HUMAN	drebrin-like isoform b	399	SH3.				activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			skin(1)	1						ACCTCATCACGGGCATCGAGG	0.587													T	44100419	T	T	44100419	2	4	172	1	0	0	0	0	0	0	0	1	4255	1103	39	5		5	DBNL	7	44100419	Silent	SNP	G	TCGA-26-1439-01A-01D-1353-08		44100419	115038244	19	12274											
POM121L12	285877	broad.mit.edu	37	chr7	53103950	53103950	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcgctaggttcgacgggccgTtgtggttcgaggtctcagac	16	10	1	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr7:53103950T>C	uc003tpz.2	+	1	602	c.586T>C	c.(586-588)TTG>CTG	p.L196L		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	196											0						CGACGGGCCGTTGTGGTTCGA	0.607													C	53103950	C	C	53103950	2	2	172	1	0	0	0	0	0	0	0	1	12241	1722	60	4		4	POM121L12	7	53103950	Silent	SNP	T	TCGA-26-1439-01A-01D-1353-08	9003531	53103950	106034713	20	12275											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	172	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	2129093	55233043	103905620	21	12276											
ADAM22	53616	broad.mit.edu	37	chr7	87760639	87760639	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttgctatggaaacctgggCgactgacaacaagtttgcca	12	9	0	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr7:87760639C>T	uc003ujn.2	+	11	960	c.881C>T	c.(880-882)GCG>GTG	p.A294V	ADAM22_uc003ujj.1_Missense_Mutation_p.A294V|ADAM22_uc003ujk.1_Missense_Mutation_p.A294V|ADAM22_uc003ujl.1_Missense_Mutation_p.A294V|ADAM22_uc003ujm.2_Missense_Mutation_p.A294V|ADAM22_uc003ujo.2_Missense_Mutation_p.A294V|ADAM22_uc003ujp.1_Missense_Mutation_p.A346V	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	294	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GAAACCTGGGCGACTGACAAC	0.358													T	87760639	T	T	87760639	3	4	172	1	0	0	0	0	1	0	0	0	244	768	27	1	923	1	ADAM22	7	87760639	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08	32527596	87760639	71378024	22	12277											
EPHB4	2050	broad.mit.edu	37	chr7	100404060	100404060	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgtcctgattgctcatgtcCcagtacggcctctccccaaa	7	16	2	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr7:100404060C>T	uc003uwn.1	-	14	2957	c.2466G>A	c.(2464-2466)TGG>TGA	p.W822*	EPHB4_uc003uwm.1_Nonsense_Mutation_p.W729*|EPHB4_uc010lhj.1_Nonsense_Mutation_p.W822*	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	822	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					TGCTCATGTCCCAGTACGGCC	0.562													T	100404060	T	T	100404060	4	4	172	1	0	0	0	0	0	1	0	0	5177	624	22	3	513	3	EPHB4	7	100404060	Nonsense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08	12643421	100404060	58734603	23	12278											
TAF2	6873	broad.mit.edu	37	chr8	120774701	120774701	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cggaagaagtttttccatatTcaaaaatctggtgatttctt	7	6	3	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr8:120774701T>G	uc003you.2	-	19	2782	c.2512A>C	c.(2512-2514)AAT>CAT	p.N838H		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	838					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTTTCCATATTCAAAAATCTG	0.313													G	120774701	G	G	120774701	3	3	172	1	0	0	0	0	1	0	0	0	15521	1783	62	5	1119	5	TAF2	8	120774701	Missense_Mutation	SNP	T	TCGA-26-1439-01A-01D-1353-08		120774701	25589321	24	12279											
FLJ43860	389690	broad.mit.edu	37	chr8	142505515	142505515	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgagccatgttcttgatctTcttgatgatgtacttcaagt	8	7	4	4			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr8:142505515T>C	uc003ywi.2	-	3	412	c.331A>G	c.(331-333)AAG>GAG	p.K111E	FLJ43860_uc011ljs.1_5'Flank|FLJ43860_uc010meu.1_5'Flank	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	111							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TTCTTGATCTTCTTGATGATG	0.527													C	142505515	C	C	142505515	3	2	172	1	0	0	0	0	1	0	0	0	5930	1792	62	4	3737	4	FLJ43860	8	142505515	Missense_Mutation	SNP	T	TCGA-26-1439-01A-01D-1353-08	21730814	142505515	3858507	25	12280											
PLEC	5339	broad.mit.edu	37	chr8	144993831	144993831	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctgcgcctccagcaggagCgcagccgttgtggctctcag	14	15	1	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr8:144993831C>T	uc003zaf.1	-	32	10739	c.10569G>A	c.(10567-10569)GCG>GCA	p.A3523A	PLEC_uc003zab.1_Silent_p.A3386A|PLEC_uc003zac.1_Silent_p.A3390A|PLEC_uc003zad.2_Silent_p.A3386A|PLEC_uc003zae.1_Silent_p.A3354A|PLEC_uc003zag.1_Silent_p.A3364A|PLEC_uc003zah.2_Silent_p.A3372A|PLEC_uc003zaj.2_Silent_p.A3413A	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3523	Plectin 13.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCAGCAGGAGCGCAGCCGTTG	0.692													T	144993831	T	T	144993831	2	4	172	1	0	0	0	0	0	0	0	1	12052	755	27	1		1	PLEC	8	144993831	Silent	SNP	C	TCGA-26-1439-01A-01D-1353-08	2488316	144993831	1370191	26	12281											
FBXL6	26233	broad.mit.edu	37	chr8	145581939	145581939	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgcgccgctgtgcgcgggGccgggcggggccgggttcgg	23	13	0	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr8:145581939G>A	uc003zcb.2	-	1	194	c.169C>T	c.(169-171)CCC>TCC	p.P57S	C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_Missense_Mutation_p.P57S|FBXL6_uc010mfx.2_5'UTR|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	57	F-box.				proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			tgtgcgcggggccgggcgggg	0.413													A	145581939	A	A	145581939	3	1	172	1	0	0	0	0	1	0	0	0	5723	1203	42	3	1486	3	FBXL6	8	145581939	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	588108	145581939	782083	27	12282											
DMRT3	58524	broad.mit.edu	37	chr9	977245	977245	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccggcagcaggccaacgagAgcttggagagcctcatcccc	13	15	1	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr9:977245A>G	uc003zgw.1	+	1	282	c.244A>G	c.(244-246)AGC>GGC	p.S82G		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	82					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GGCCAACGAGAGCTTGGAGAG	0.483													G	977245	G	G	977245	3	3	172	1	0	0	0	0	1	0	0	0	4587	304	11	4	246	4	DMRT3	9	977245	Missense_Mutation	SNP	A	TCGA-26-1439-01A-01D-1353-08		977245	140236186	28	12283											
CACNA1B	774	broad.mit.edu	37	chr9	141014620	141014620	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtcctttgcccacagcccGtcacagatgccagccccatg	8	18	1	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr9:141014620G>A	uc004cog.2	+	44	6179	c.6034G>A	c.(6034-6036)GTC>ATC	p.V2012I	CACNA1B_uc004coi.2_Missense_Mutation_p.V1224I	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	2012	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCCACAGCCCGTCACAGATGC	0.672													A	141014620	A	A	141014620	3	1	172	1	0	0	0	0	1	0	0	0	2539	1145	40	1	6208	1	CACNA1B	9	141014620	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	140037375	141014620	198811	29	12284											
AKR1C4	1109	broad.mit.edu	37	chr10	5254979	5254979	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tggacccaaactccccagttCttttggaggacccagttctt	8	13	2	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr10:5254979C>A	uc001ihw.2	+	7	736	c.703C>A	c.(703-705)CTT>ATT	p.L235I		NM_001818	NP_001809	P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	235	NADP.				androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			ovary(1)	1					NADH(DB00157)	CTCCCCAGTTCTTTTGGAGGA	0.527													A	5254979	A	A	5254979	3	1	172	1	0	0	0	0	1	0	0	0	472	913	32	5	729	5	AKR1C4	10	5254979	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08		5254979	130279768	30	12285											
HPS6	79803	broad.mit.edu	37	chr10	103825336	103825336	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gactcagcggtccgagtccgTggcagtccggacggccgcca	15	15	1	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr10:103825336T>C	uc001kuj.2	+	1	190	c.105T>C	c.(103-105)CGT>CGC	p.R35R		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	35						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		TCCGAGTCCGTGGCAGTCCGG	0.756									Hermansky-Pudlak_syndrome				C	103825336	C	C	103825336	2	2	172	1	0	0	0	0	0	0	0	1	7343	1683	59	4		4	HPS6	10	103825336	Silent	SNP	T	TCGA-26-1439-01A-01D-1353-08	98570357	103825336	31709411	31	12286											
NPAS4	266743	broad.mit.edu	37	chr11	66192484	66192484	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taacatgttcctggaagagaCgcccgtggaagacatcttca	10	10	2	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr11:66192484C>T	uc001ohx.1	+	7	2299	c.2123C>T	c.(2122-2124)ACG>ATG	p.T708M	NPAS4_uc010rpc.1_Missense_Mutation_p.T498M	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	708					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CTGGAAGAGACGCCCGTGGAA	0.612													T	66192484	T	T	66192484	3	4	172	1	0	0	0	0	1	0	0	0	10565	536	19	1	2149	1	NPAS4	11	66192484	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08		66192484	68814032	32	12287											
CABP4	57010	broad.mit.edu	37	chr11	67225127	67225127	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcgcacatgctgggggtgCgagagctgcgcatcgccttc	16	13	0	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr11:67225127C>T	uc001olo.2	+	4	702	c.625C>T	c.(625-627)CGA>TGA	p.R209*	CABP4_uc001oln.2_Nonsense_Mutation_p.R104*	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	209	EF-hand 3.				visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GCTGGGGGTGCGAGAGCTGCG	0.637													T	67225127	T	T	67225127	4	4	172	1	0	0	0	0	0	1	0	0	2533	760	27	1	639	1	CABP4	11	67225127	Nonsense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08	1032643	67225127	67781389	33	12288											
SORL1	6653	broad.mit.edu	37	chr11	121424742	121424742	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgcctctcaccgggctacGggcagcagtggccctggact	14	14	1	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr11:121424742G>A	uc001pxx.2	+	17	2443	c.2363G>A	c.(2362-2364)CGG>CAG	p.R788Q		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	788	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ACCGGGCTACGGGCAGCAGTG	0.562													A	121424742	A	A	121424742	3	1	172	1	0	0	0	0	1	0	0	0	14934	1116	39	2	2429	2	SORL1	11	121424742	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	54199615	121424742	13581774	34	12289											
TFDP1	7027	broad.mit.edu	37	chr13	114294537	114294537	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtcctacgtcggggaggaCgacgaggaggacgatgactt	17	8	0	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr13:114294537C>T	uc001vtw.2	+	12	1400	c.1188C>T	c.(1186-1188)GAC>GAT	p.D396D	TFDP1_uc010tkd.1_Silent_p.D297D|TFDP1_uc010tke.1_Silent_p.D367D|TFDP1_uc001vty.3_Silent_p.D392D|TFDP1_uc001vtx.2_3'UTR	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	396	Asp/Glu-rich (acidic; NCB domain).				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			tcggggaggacgacgaggagg	0.378										TSP Lung(29;0.18)			T	114294537	T	T	114294537	2	4	172	1	0	0	0	0	0	0	0	1	15794	535	19	1		1	TFDP1	13	114294537	Silent	SNP	C	TCGA-26-1439-01A-01D-1353-08		114294537	875341	35	12290											
CDC42BPB	9578	broad.mit.edu	37	chr14	103523372	103523372	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccacgtacttgtcgcggcGcagggccgagtggctgcact	16	13	0	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr14:103523372G>A	uc001ymi.1	-	1	371	c.139C>T	c.(139-141)CGC>TGC	p.R47C		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	47					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TTGTCGCGGCGCAGGGCCGAG	0.721													A	103523372	A	A	103523372	3	1	172	1	0	0	0	0	1	0	0	0	3073	1087	38	1	5144	1	CDC42BPB	14	103523372	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08		103523372	3826168	36	12291											
KIAA1370	56204	broad.mit.edu	37	chr15	52902145	52902145	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgattttatatcacctatAccactaaagcctagaatatt	4	8	1	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr15:52902145A>G	uc002acg.3	-	6	1119	c.966T>C	c.(964-966)GGT>GGC	p.G322G	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Silent_p.G234G|KIAA1370_uc010ugf.1_Silent_p.G329G	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	322											0				all cancers(107;0.0803)		TATCACCTATACCACTAAAGC	0.383													G	52902145	G	G	52902145	2	3	172	1	0	0	0	0	0	0	0	1	8226	378	14	4		4	KIAA1370	15	52902145	Silent	SNP	A	TCGA-26-1439-01A-01D-1353-08		52902145	49629247	37	12292											
ANPEP	290	broad.mit.edu	37	chr15	90349552	90349552	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtgaggtacggtctcagcGtcacccggtaggaatcgggt	17	9	2	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr15:90349552G>A	uc002bop.3	-	2	555	c.263C>T	c.(262-264)ACG>ATG	p.T88M		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	88	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CGGTCTCAGCGTCACCCGGTA	0.597													A	90349552	A	A	90349552	3	1	172	1	0	0	0	0	1	0	0	0	710	1145	40	1	2720	1	ANPEP	15	90349552	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	37447407	90349552	12181840	38	12293											
NOD2	64127	broad.mit.edu	37	chr16	50745689	50745689	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cactcagtgctgatgtgccaCcagctttgctcagacacctc	8	15	2	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr16:50745689C>G	uc002egm.1	+	4	1972	c.1867C>G	c.(1867-1869)CCA>GCA	p.P623A	NOD2_uc010cbk.1_Missense_Mutation_p.P596A|NOD2_uc002egl.1_Missense_Mutation_p.P401A|NOD2_uc010cbl.1_Missense_Mutation_p.P401A|NOD2_uc010cbm.1_Missense_Mutation_p.P401A|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	623					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				TGATGTGCCACCAGCTTTGCT	0.582													G	50745689	G	G	50745689	3	3	172	1	0	0	0	0	1	0	0	0	10517	507	18	5	1881	5	NOD2	16	50745689	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08		50745689	39609064	39	12294											
NUP93	9688	broad.mit.edu	37	chr16	56865910	56865910	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacaaaactgaggattacctGtggctgaaggtaggcactgt	13	7	0	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr16:56865910G>A	uc002eka.2	+	11	1363	c.1242G>A	c.(1240-1242)CTG>CTA	p.L414L	NUP93_uc002ekb.2_Silent_p.L291L|NUP93_uc010vhi.1_Silent_p.L291L	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	414					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						AGGATTACCTGTGGCTGAAGG	0.502													A	56865910	A	A	56865910	2	1	172	1	0	0	0	0	0	0	0	1	10772	1364	48	3		3	NUP93	16	56865910	Silent	SNP	G	TCGA-26-1439-01A-01D-1353-08	6120221	56865910	33488843	40	12295											
CDYL2	124359	broad.mit.edu	37	chr16	80718650	80718650	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtagtcctgtaagacaccGtcttggtggccctgtcacct	12	12	2	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr16:80718650G>A	uc002ffs.2	-	2	506	c.401C>T	c.(400-402)ACG>ATG	p.T134M		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	134						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						GTAAGACACCGTCTTGGTGGC	0.537													A	80718650	A	A	80718650	3	1	172	1	0	0	0	0	1	0	0	0	3186	1145	40	1	1143	1	CDYL2	16	80718650	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	23852740	80718650	9636103	41	12296											
NLRP1	22861	broad.mit.edu	37	chr17	5418262	5418262	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccagcaccctctcgtactGctcctggctcagcacctgtc	8	18	2	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr17:5418262G>A	uc002gci.2	-	17	4789	c.4234C>T	c.(4234-4236)CAG>TAG	p.Q1412*	NLRP1_uc002gcg.1_Intron|NLRP1_uc002gck.2_Nonsense_Mutation_p.Q1368*|NLRP1_uc002gcj.2_Nonsense_Mutation_p.Q1382*|NLRP1_uc002gcl.2_Nonsense_Mutation_p.Q1338*|NLRP1_uc002gch.3_Nonsense_Mutation_p.Q1368*	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1412	CARD.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				CTCTCGTACTGCTCCTGGCTC	0.572													A	5418262	A	A	5418262	4	1	172	1	0	0	0	0	0	1	0	0	10471	1328	46	3	254	3	NLRP1	17	5418262	Nonsense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08		5418262	75776948	42	12297											
DNAH2	146754	broad.mit.edu	37	chr17	7708677	7708677	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttatgattcttcgaggcaaCgagcccacatgggcagaggc	13	10	1	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr17:7708677C>T	uc002giu.1	+	60	9422	c.9408C>T	c.(9406-9408)AAC>AAT	p.N3136N	DNAH2_uc010cnm.1_Silent_p.N74N	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3136	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TTCGAGGCAACGAGCCCACAT	0.403													T	7708677	T	T	7708677	2	4	172	1	0	0	0	0	0	0	0	1	4602	535	19	1		1	DNAH2	17	7708677	Silent	SNP	C	TCGA-26-1439-01A-01D-1353-08	2290415	7708677	73486533	43	12298											
PRPSAP2	5636	broad.mit.edu	37	chr17	18833933	18833933	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	actgtggatatcagcatgatCctttcagaggcgatccgtcg	11	10	2	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr17:18833933C>T	uc002gup.1	+	12	1243	c.1032C>T	c.(1030-1032)ATC>ATT	p.I344I	PRPSAP2_uc002guo.1_Silent_p.I258I|PRPSAP2_uc010vyi.1_Silent_p.I292I|PRPSAP2_uc010vyj.1_Silent_p.I258I|PRPSAP2_uc010vyk.1_Silent_p.I283I|PRPSAP2_uc002guq.1_Silent_p.I131I	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	344					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						TCAGCATGATCCTTTCAGAGG	0.448													T	18833933	T	T	18833933	2	4	172	1	0	0	0	0	0	0	0	1	12582	845	30	3		3	PRPSAP2	17	18833933	Silent	SNP	C	TCGA-26-1439-01A-01D-1353-08	11125256	18833933	62361277	44	12299											
SLC6A4	6532	broad.mit.edu	37	chr17	28537542	28537542	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgatactcacaaaagtcagGgtgaccagggatccaaagaa	10	8	2	3			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr17:28537542G>A	uc002hey.3	-	11	1984	c.1440C>T	c.(1438-1440)ACC>ACT	p.T480T	SLC6A4_uc010csg.2_RNA	NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	480	Helical; Name=9; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CAAAAGTCAGGGTGACCAGGG	0.582													A	28537542	A	A	28537542	2	1	172	1	0	0	0	0	0	0	0	1	14686	1219	43	3		3	SLC6A4	17	28537542	Silent	SNP	G	TCGA-26-1439-01A-01D-1353-08	9703609	28537542	52657668	45	12300											
C17orf71	55181	broad.mit.edu	37	chr17	57288448	57288448	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	taccgggaagccaggaggagGacccagtaggtatgttgctg	16	8	0	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr17:57288448G>A	uc002ixi.2	+	1	1078	c.1036G>A	c.(1036-1038)GAC>AAC	p.D346N		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	346					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					CCAGGAGGAGGACCCAGTAGG	0.527													A	57288448	A	A	57288448	3	1	172	1	0	0	0	0	1	0	0	0	1878	1174	41	3	1038	3	C17orf71	17	57288448	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	28750906	57288448	23906762	46	12301											
ABCA5	23461	broad.mit.edu	37	chr17	67305454	67305454	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatcatatcaggaaaaaaacGaagttcataggacatggagt	9	5	3	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr17:67305454G>A	uc002jif.2	-	3	1636	c.418C>T	c.(418-420)CGT>TGT	p.R140C	ABCA5_uc002jig.2_Missense_Mutation_p.R140C|ABCA5_uc002jih.2_Missense_Mutation_p.R140C|ABCA5_uc010dfe.2_Missense_Mutation_p.R140C	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	140					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					GGAAAAAAACGAAGTTCATAG	0.328													A	67305454	A	A	67305454	3	1	172	1	0	0	0	0	1	0	0	0	35	1058	37	2	4654	2	ABCA5	17	67305454	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	10017006	67305454	13889756	47	12302											
RECQL5	9400	broad.mit.edu	37	chr17	73626864	73626864	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgcccgtctcttaccttcaCagtcagcctggggatcctcc	8	17	3	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr17:73626864C>G	uc010dgl.2	-	12	1795	c.1639G>C	c.(1639-1641)GTG>CTG	p.V547L	RECQL5_uc010dgk.2_Missense_Mutation_p.V520L|RECQL5_uc002jot.3_5'Flank|LOC643008_uc002jow.2_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	547					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			CTTACCTTCACAGTCAGCCTG	0.657								Other_identified_genes_with_known_or_suspected_DNA_repair_function					G	73626864	G	G	73626864	3	3	172	1	0	0	0	0	1	0	0	0	13203	478	17	5	1372	5	RECQL5	17	73626864	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08	6321410	73626864	7568346	48	12303											
GALK1	2584	broad.mit.edu	37	chr17	73754163	73754163	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gcacagcaccttggctccatCggctgcttgagagaggtaga	13	11	0	3			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr17:73754163C>A	uc010wsi.1	-	8	1216	c.1153G>T	c.(1153-1155)GAT>TAT	p.D385Y	GALK1_uc002jpk.2_Missense_Mutation_p.D385Y	NM_000154	NP_000145	P51570	GALK1_HUMAN	galactokinase 1	385					galactose catabolic process	cytosol	ATP binding|galactokinase activity|galactose binding				0	all_cancers(13;1.5e-07)		all cancers(21;1.03e-06)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTGGCTCCATCGGCTGCTTGA	0.682													A	73754163	A	A	73754163	3	1	172	1	0	0	0	0	1	0	0	0	6203	884	31	5	29	5	GALK1	17	73754163	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08	127299	73754163	7441047	49	12304											
OR10H3	26532	broad.mit.edu	37	chr19	15852470	15852470	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctgatctgctcttcaccCatcgttccatcacctttgtg	7	14	4	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr19:15852470C>T	uc010xoq.1	+	1	268	c.268C>T	c.(268-270)CAT>TAT	p.H90Y		NM_013938	NP_039226	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTCTTCACCCATCGTTCCAT	0.502													T	15852470	T	T	15852470	3	4	172	1	0	0	0	0	1	0	0	0	10907	594	21	3	270	3	OR10H3	19	15852470	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08		15852470	43276513	50	12305											
CPAMD8	27151	broad.mit.edu	37	chr19	17017835	17017835	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcggagcagggtcagcgcGtaggtagtcagggcacagct	17	10	2	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr19:17017835G>A	uc002nfb.2	-	30	4127	c.4095C>T	c.(4093-4095)TAC>TAT	p.Y1365Y		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1318						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGGTCAGCGCGTAGGTAGTCA	0.662													A	17017835	A	A	17017835	2	1	172	1	0	0	0	0	0	0	0	1	3795	1140	40	1		1	CPAMD8	19	17017835	Silent	SNP	G	TCGA-26-1439-01A-01D-1353-08	1165365	17017835	42111148	51	12306											
PSG1	5669	broad.mit.edu	37	chr19	43373123	43373123	+	Nonsense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taggttcacaggtgaagtttAagacatccttattctccctg	8	9	2	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr19:43373123A>C	uc002ovb.2	-	4	911	c.773T>G	c.(772-774)TTA>TGA	p.L258*	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Nonsense_Mutation_p.L258*|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Nonsense_Mutation_p.L258*|PSG1_uc010eio.1_Nonsense_Mutation_p.L258*|PSG1_uc002oux.1_Nonsense_Mutation_p.L187*|PSG1_uc002ouy.1_Intron|PSG1_uc002ouz.1_Nonsense_Mutation_p.L258*|PSG1_uc002ova.1_Nonsense_Mutation_p.L165*|PSG1_uc002ovc.2_Nonsense_Mutation_p.L165*|PSG1_uc002ovd.1_Nonsense_Mutation_p.L258*	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	258	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GGTGAAGTTTAAGACATCCTT	0.488													C	43373123	C	C	43373123	4	2	172	1	0	0	0	0	0	1	0	0	12653	372	13	5	551	5	PSG1	19	43373123	Nonsense_Mutation	SNP	A	TCGA-26-1439-01A-01D-1353-08	26355288	43373123	15755860	52	12307											
SPTLC3	55304	broad.mit.edu	37	chr20	13052931	13052931	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgccactgtatcaagactttGaaaatttttatacaagaaac	5	7	1	3			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr20:13052931G>C	uc002wod.1	+	3	620	c.331G>C	c.(331-333)GAA>CAA	p.E111Q		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	111					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	TCAAGACTTTGAAAATTTTTA	0.428													C	13052931	C	C	13052931	3	2	172	1	0	0	0	0	1	0	0	0	15124	1291	45	5	341	5	SPTLC3	20	13052931	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08		13052931	49972589	53	12308											
KRTAP10-11	386678	broad.mit.edu	37	chr21	46066487	46066487	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcgcccccagctgctgcGccccggccccctccctgagc	11	23	0	1			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr21:46066487G>A	uc002zfr.3	+	1	157	c.112G>A	c.(112-114)GCC>ACC	p.A38T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	38	2.|25 X 5 AA repeats of C-C-X(3).					keratin filament				ovary(1)	1						CAGCTGCTGCGCCCCGGCCCC	0.697													A	46066487	A	A	46066487	3	1	172	1	0	0	0	0	1	0	0	0	8507	1087	38	1	114	1	KRTAP10-11	21	46066487	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08		46066487	2063408	54	12309											
CECR6	27439	broad.mit.edu	37	chr22	17600851	17600851	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagcatccggccgcgcggtgCcgctggggctgcagcagcag	17	14	0	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr22:17600851C>T	uc002zmb.2	-	1	1363	c.1167G>A	c.(1165-1167)CGG>CGA	p.R389R	CECR6_uc002zma.2_Silent_p.R34R|uc002zmc.2_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	389											0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		CCGCGCGGTGCCGCTGGGGCT	0.736													T	17600851	T	T	17600851	2	4	172	1	0	0	0	0	0	0	0	1	3208	726	26	3		3	CECR6	22	17600851	Silent	SNP	C	TCGA-26-1439-01A-01D-1353-08		17600851	33703715	55	12310											
GNB1L	54584	broad.mit.edu	37	chr22	19794193	19794193	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gggccttacctgccacagccGcaggcacatgggcatgccca	12	16	0	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr22:19794193G>C	uc002zqe.1	-	5	899	c.505C>G	c.(505-507)CGG>GGG	p.R169G	GNB1L_uc002zqd.1_Missense_Mutation_p.R25G|GNB1L_uc002zqf.1_Missense_Mutation_p.R169G	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	169	WD 3.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					TGCCACAGCCGCAGGCACATG	0.607													C	19794193	C	C	19794193	3	2	172	1	0	0	0	0	1	0	0	0	6516	1086	38	5	490	5	GNB1L	22	19794193	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	2193342	19794193	31510373	56	12311											
CSF2RB	1439	broad.mit.edu	37	chr22	37325775	37325775	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtggcccgagtacggacccGcctggccccaggttctcggc	14	17	1	0	rs149714683		TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr22:37325775G>A	uc003aqa.3	+	6	861	c.644G>A	c.(643-645)CGC>CAC	p.R215H	CSF2RB_uc003aqc.3_Missense_Mutation_p.R215H	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	215	Fibronectin type-III 1.|Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	GTACGGACCCGCCTGGCCCCA	0.647													A	37325775	A	A	37325775	3	1	172	1	0	0	0	0	1	0	0	0	3935	1087	38	1	662	1	CSF2RB	22	37325775	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	17531582	37325775	13978791	57	12312											
SSTR3	6753	broad.mit.edu	37	chr22	37603101	37603101	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgcgttcggagcgccgccGccgctggcacgagggtgccc	16	17	0	0			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chr22:37603101G>A	uc003ara.2	-	2	804	c.742C>T	c.(742-744)CGG>TGG	p.R248W	SSTR3_uc003arb.2_Missense_Mutation_p.R248W	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	248	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						GAGCGCCGCCGCCGCTGGCAC	0.667													A	37603101	A	A	37603101	3	1	172	1	0	0	0	0	1	0	0	0	15198	1086	38	1	518	1	SSTR3	22	37603101	Missense_Mutation	SNP	G	TCGA-26-1439-01A-01D-1353-08	277326	37603101	13701465	58	12313											
EFNB1	1947	broad.mit.edu	37	chrX	68058542	68058542	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcccccgagcagaagcagggCggccctatgagtactacaag	13	13	0	2			TCGA-26-1439-01A-01D-1353-08	TCGA-26-1439-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0d78dbfc-db49-42a2-a399-593c4b0839ff	07608301-2532-446d-acff-641e40d2e038	g.chrX:68058542C>G	uc004dxd.3	+	2	991	c.211C>G	c.(211-213)CGG>GGG	p.R71G	EFNB1_uc004dxe.2_Missense_Mutation_p.R71G	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	71	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						AGAAGCAGGGCGGCCCTATGA	0.572													G	68058542	G	G	68058542	3	3	172	1	0	0	0	0	1	0	0	0	4955	759	27	5	217	5	EFNB1	23	68058542	Missense_Mutation	SNP	C	TCGA-26-1439-01A-01D-1353-08		68058542	87212018	59	12314											
TIE1	7075	broad.mit.edu	37	chr1	43778133	43778133	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaggagcggcgggagaaCgtctcatccccccaggcccg	16	15	1	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr1:43778133C>T	uc001ciu.2	+	12	1867	c.1788C>T	c.(1786-1788)AAC>AAT	p.N596N	TIE1_uc010okd.1_Silent_p.N596N|TIE1_uc010oke.1_Silent_p.N551N|TIE1_uc009vwq.2_Silent_p.N552N|TIE1_uc010okf.1_Silent_p.N241N|TIE1_uc010okg.1_Silent_p.N241N	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	596	Fibronectin type-III 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGCGGGAGAACGTCTCATCCC	0.697													T	43778133	T	T	43778133	2	4	173	1	0	0	0	0	0	0	0	1	15890	535	19	1		1	TIE1	1	43778133	Silent	SNP	C	TCGA-26-1442-01A-01D-1696-08		43778133	205472488	1	12315											
DNAJB4	11080	broad.mit.edu	37	chr1	78478954	78478954	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cagcatgaatggatatccaaGagacaggaattctgtggggc	13	7	1	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr1:78478954G>C	uc001dij.2	+	2	590	c.431G>C	c.(430-432)AGA>ACA	p.R144T	DNAJB4_uc010orn.1_Missense_Mutation_p.R29T	NM_007034	NP_008965	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4	144					protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding				0						GGATATCCAAGAGACAGGAAT	0.413													C	78478954	C	C	78478954	3	2	173	1	0	0	0	0	1	0	0	0	4622	942	33	5	437	5	DNAJB4	1	78478954	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	34700821	78478954	170771667	2	12316											
S100A8	6279	broad.mit.edu	37	chr1	153362982	153362982	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggtagacgtcgatgatagaGttcaaggctttctccagctc	11	9	2	3			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr1:153362982G>T	uc001fbs.2	-	2	85	c.30C>A	c.(28-30)AAC>AAA	p.N10K		NM_002964	NP_002955	P05109	S10A8_HUMAN	S100 calcium-binding protein A8	10					chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			CGATGATAGAGTTCAAGGCTT	0.502													T	153362982	T	T	153362982	3	4	173	1	0	0	0	0	1	0	0	0	13786	1020	36	5	259	5	S100A8	1	153362982	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	74884028	153362982	95887639	3	12317											
C1orf14	81626	broad.mit.edu	37	chr1	182920519	182920519	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acaaagaatacactgggattAgtcttccagactccaagcca	7	11	1	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr1:182920519A>T	uc001gpu.2	-	2	774	c.489T>A	c.(487-489)ACT>ACA	p.T163T	C1orf14_uc001gpv.2_Silent_p.T44T|C1orf14_uc010pnz.1_Silent_p.T21T|C1orf14_uc001gpw.2_5'UTR	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	235											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		CACTGGGATTAGTCTTCCAGA	0.318													T	182920519	T	T	182920519	2	4	173	1	0	0	0	0	0	0	0	1	2000	407	15	5		5	C1orf14	1	182920519	Silent	SNP	A	TCGA-26-1442-01A-01D-1696-08	29557537	182920519	66330102	4	12318											
CFHR4	10877	broad.mit.edu	37	chr1	196887345	196887345	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttttctgctttcagatccaTgtataataactgaagaaaac	5	7	2	3			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr1:196887345T>C	uc001gto.2	+	6	874	c.805T>C	c.(805-807)TGT>CGT	p.C269R	CFHR4_uc009wyy.2_Missense_Mutation_p.C515R|CFHR4_uc001gtp.2_Missense_Mutation_p.C516R	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	269	Sushi 5.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TTCAGATCCATGTATAATAAC	0.259													C	196887345	C	C	196887345	3	2	173	1	0	0	0	0	1	0	0	0	3287	1464	51	4	827	4	CFHR4	1	196887345	Missense_Mutation	SNP	T	TCGA-26-1442-01A-01D-1696-08	13966826	196887345	52363276	5	12319											
CACNA1S	779	broad.mit.edu	37	chr1	201042718	201042718	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctcacccttgggtttctgctCcagcttcttggccatcgttg	9	14	3	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr1:201042718C>G	uc001gvv.2	-	15	2343	c.2116G>C	c.(2116-2118)GAG>CAG	p.E706Q		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	706	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GGTTTCTGCTCCAGCTTCTTG	0.542													G	201042718	G	G	201042718	3	3	173	1	0	0	0	0	1	0	0	0	2547	864	30	5	3625	5	CACNA1S	1	201042718	Missense_Mutation	SNP	C	TCGA-26-1442-01A-01D-1696-08	4155373	201042718	48207903	6	12320											
USH2A	7399	broad.mit.edu	37	chr1	216348801	216348801	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gctgttgattcctttaaccaGaggtggcctcagttgtgctg	12	9	1	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr1:216348801G>C	uc001hku.1	-	21	4807	c.4420C>G	c.(4420-4422)CTG>GTG	p.L1474V	USH2A_uc001hkv.2_Missense_Mutation_p.L1474V	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1474	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCTTTAACCAGAGGTGGCCTC	0.403										HNSCC(13;0.011)			C	216348801	C	C	216348801	3	2	173	1	0	0	0	0	1	0	0	0	17033	933	33	5	11410	5	USH2A	1	216348801	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	15306083	216348801	32901820	7	12321											
TTC27	55622	broad.mit.edu	37	chr2	33036261	33036261	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cacgtatatggaaatgggcaGagtgaaaagcctgatgaaaa	12	5	0	4			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr2:33036261G>C	uc002rom.2	+	17	2400	c.2169G>C	c.(2167-2169)CAG>CAC	p.Q723H	TTC27_uc010ymx.1_Missense_Mutation_p.Q673H|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	723							protein binding			central_nervous_system(1)	1						GAAATGGGCAGAGTGAAAAGC	0.428													C	33036261	C	C	33036261	3	2	173	1	0	0	0	0	1	0	0	0	16692	933	33	5	2235	5	TTC27	2	33036261	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08		33036261	210163112	8	12322											
INO80B	83444	broad.mit.edu	37	chr2	74684891	74684891	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgccgctacgcttgctcccGcacaggccaggcactctgta	11	17	1	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr2:74684891G>A	uc002slg.2	+	5	1016	c.971G>A	c.(970-972)CGC>CAC	p.R324H	INO80B_uc002slf.1_3'UTR|INO80B_uc010yrr.1_Missense_Mutation_p.R296H|WBP1_uc002slh.1_Intron|INO80B_uc002sli.1_RNA|INO80B_uc010yrs.1_Missense_Mutation_p.R342H|WBP1_uc002slj.1_5'Flank|WBP1_uc002slk.1_5'Flank|WBP1_uc002sll.1_5'Flank	NM_031288	NP_112578	Q9C086	IN80B_HUMAN	high mobility group AT-hook 1-like 4	324	HIT-type.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|nucleolus	metal ion binding|protein binding			pancreas(1)	1						GCTTGCTCCCGCACAGGCCAG	0.697													A	74684891	A	A	74684891	3	1	173	1	0	0	0	0	1	0	0	0	7747	1087	38	1	989	1	INO80B	2	74684891	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	41648630	74684891	168514482	9	12323											
KIF5C	3800	broad.mit.edu	37	chr2	149857246	149857246	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tgtttttcagattgctcaacGataaaagggaacaagccaga	9	7	2	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr2:149857246G>C	uc010zbu.1	+	21	2691	c.2323G>C	c.(2323-2325)GAT>CAT	p.D775H	KIF5C_uc002tws.1_RNA|KIF5C_uc002twu.1_Missense_Mutation_p.D57H	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	775					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		ATTGCTCAACGATAAAAGGGA	0.423													C	149857246	C	C	149857246	3	2	173	1	0	0	0	0	1	0	0	0	8307	1058	37	5	2327	5	KIF5C	2	149857246	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	75172355	149857246	93342127	10	12324											
COQ10B	80219	broad.mit.edu	37	chr2	198318368	198318368	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgacagcggccggggcgcaGgcgcccgtgcggaatggcag	20	13	0	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr2:198318368G>A	uc002uuh.1	+	1	138	c.84G>A	c.(82-84)CAG>CAA	p.Q28Q	COQ10B_uc010fsl.1_5'Flank	NM_025147	NP_079423	Q9H8M1	CQ10B_HUMAN	coenzyme Q10 homolog B precursor	28						mitochondrial inner membrane					0			Epithelial(96;0.231)|OV - Ovarian serous cystadenocarcinoma(117;0.246)			CCGGGGCGCAGGCGCCCGTGC	0.627													A	198318368	A	A	198318368	2	1	173	1	0	0	0	0	0	0	0	1	3744	991	35	3		3	COQ10B	2	198318368	Silent	SNP	G	TCGA-26-1442-01A-01D-1696-08	48461122	198318368	44881005	11	12325											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	173	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-26-1442-01A-01D-1696-08	10794744	209113112	34086261	12	12326											
SMARCC1	6599	broad.mit.edu	37	chr3	47755965	47755965	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcatcaacatcattactatgGacccaagtatcatagctata	5	10	3	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr3:47755965G>A	uc003crq.2	-	8	850	c.732C>T	c.(730-732)GTC>GTT	p.V244V	SMARCC1_uc011bbd.1_Silent_p.V135V	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	244					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		CATTACTATGGACCCAAGTAT	0.274													A	47755965	A	A	47755965	2	1	173	1	0	0	0	0	0	0	0	1	14775	1161	41	3		3	SMARCC1	3	47755965	Silent	SNP	G	TCGA-26-1442-01A-01D-1696-08		47755965	150266465	13	12327											
ITIH1	3697	broad.mit.edu	37	chr3	52822082	52822082	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccagaccgagtgaccggcGgtgagtccttggaagggtct	16	10	1	3			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr3:52822082G>A	uc003dfs.2	+	17	2029	c.2005G>A	c.(2005-2007)GTG>ATG	p.V669M	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Missense_Mutation_p.V270M|ITIH1_uc010hmo.1_Missense_Mutation_p.V223M|ITIH1_uc003dfu.2_Missense_Mutation_p.V35M	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	669	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		AGTGACCGGCGGTGAGTCCTT	0.607													A	52822082	A	A	52822082	3	1	173	1	0	0	0	0	1	0	0	0	7903	1130	39	2	2071	2	ITIH1	3	52822082	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	5066117	52822082	145200348	14	12328											
DZIP1L	199221	broad.mit.edu	37	chr3	137799416	137799416	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtaaggtcccaccttcctcTggagagtcctcctctgtgtc	9	14	2	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr3:137799416T>C	uc003erq.2	-	10	1644	c.1281A>G	c.(1279-1281)CCA>CCG	p.P427P	DZIP1L_uc003err.1_Silent_p.P427P	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	427						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						CACCTTCCTCTGGAGAGTCCT	0.522													C	137799416	C	C	137799416	2	2	173	1	0	0	0	0	0	0	0	1	4864	1567	55	4		4	DZIP1L	3	137799416	Silent	SNP	T	TCGA-26-1442-01A-01D-1696-08	84977334	137799416	60223014	15	12329											
ZBTB38	253461	broad.mit.edu	37	chr3	141162963	141162963	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaatgcaagagagccccttAtaagagctaccgaaattctt	8	9	1	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr3:141162963A>G	uc003etw.2	+	8	2715	c.1733A>G	c.(1732-1734)TAT>TGT	p.Y578C	ZBTB38_uc010hun.2_Missense_Mutation_p.Y575C|ZBTB38_uc010huo.2_Missense_Mutation_p.Y578C|ZBTB38_uc003ety.2_Missense_Mutation_p.Y578C|ZBTB38_uc010hup.2_Missense_Mutation_p.Y579C	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	578					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AGAGCCCCTTATAAGAGCTAC	0.408													G	141162963	G	G	141162963	3	3	173	1	0	0	0	0	1	0	0	0	17536	449	16	4	1735	4	ZBTB38	3	141162963	Missense_Mutation	SNP	A	TCGA-26-1442-01A-01D-1696-08	3363547	141162963	56859467	16	12330											
TRIML1	339976	broad.mit.edu	37	chr4	189068016	189068016	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gccacagctaatgcctatctCgtgttgtcggaggatctgaa	11	10	2	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr4:189068016C>T	uc003izm.1	+	6	1012	c.897C>T	c.(895-897)CTC>CTT	p.L299L	TRIML1_uc003izn.1_Silent_p.L23L	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	299	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		ATGCCTATCTCGTGTTGTCGG	0.512													T	189068016	T	T	189068016	2	4	173	1	0	0	0	0	0	0	0	1	16547	871	31	2		2	TRIML1	4	189068016	Silent	SNP	C	TCGA-26-1442-01A-01D-1696-08		189068016	2086260	17	12331											
CNOT8	9337	broad.mit.edu	37	chr5	154250226	154250226	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caccttgttttttagagaggAcatgtactcccaggattcca	8	10	0	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr5:154250226A>G	uc003lvu.2	+	5	796	c.317A>G	c.(316-318)GAC>GGC	p.D106G	CNOT8_uc011ddf.1_5'UTR|CNOT8_uc011ddg.1_5'UTR|CNOT8_uc011ddh.1_Intron|CNOT8_uc003lvv.2_Missense_Mutation_p.D106G|CNOT8_uc010jig.2_5'UTR|CNOT8_uc010jif.2_5'UTR|CNOT8_uc003lvw.2_Missense_Mutation_p.D106G|CNOT8_uc011ddi.1_5'UTR|CNOT8_uc011ddj.1_Intron	NM_004779	NP_004770	Q9UFF9	CNOT8_HUMAN	CCR4-NOT transcription complex, subunit 8	106					negative regulation of cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTTAGAGAGGACATGTACTCC	0.393								Direct_reversal_of_damage					G	154250226	G	G	154250226	3	3	173	1	0	0	0	0	1	0	0	0	3625	275	10	4	327	4	CNOT8	5	154250226	Missense_Mutation	SNP	A	TCGA-26-1442-01A-01D-1696-08		154250226	26665034	18	12332											
HIST1H1T	3010	broad.mit.edu	37	chr6	26107726	26107726	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tagatgtggcctttctaacaTtaacttcatgatgttgggtc	9	7	2	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr6:26107726T>A	uc003ngj.2	-	1	639	c.596A>T	c.(595-597)AAT>ATT	p.N199I		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	199					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						CTTTCTAACATTAACTTCATG	0.448													A	26107726	A	A	26107726	3	1	173	1	0	0	0	0	1	0	0	0	7127	1493	52	5	31	5	HIST1H1T	6	26107726	Missense_Mutation	SNP	T	TCGA-26-1442-01A-01D-1696-08		26107726	145007341	19	12333											
NCOA7	135112	broad.mit.edu	37	chr6	126210501	126210501	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggtggaatgcacaaaaaagAcaccttgaaggagtgccttt	11	7	0	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr6:126210501A>T	uc010kes.2	+	11	1750	c.1301A>T	c.(1300-1302)GAC>GTC	p.D434V	NCOA7_uc003qae.3_Missense_Mutation_p.D434V|NCOA7_uc003qah.2_Missense_Mutation_p.D423V|NCOA7_uc003qai.2_Missense_Mutation_p.D434V|NCOA7_uc010ket.2_Missense_Mutation_p.D319V	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	434					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		CACAAAAAAGACACCTTGAAG	0.423													T	126210501	T	T	126210501	3	4	173	1	0	0	0	0	1	0	0	0	10234	275	10	5	1331	5	NCOA7	6	126210501	Missense_Mutation	SNP	A	TCGA-26-1442-01A-01D-1696-08	100102775	126210501	44904566	20	12334											
TNRC18	84629	broad.mit.edu	37	chr7	5354614	5354614	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctggggaccaggccaacctaCcacccttggccttggcgctg	12	16	0	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr7:5354614C>A	uc003soi.3	-	26	7376	c.7027_splice	c.e26+1	p.D2343_splice		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18								DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GGCCAACCTACCACCCTTGGC	0.672													A	5354614	A	A	5354614	5	1	173	1	0	0	0	0	0	0	1	0	16336	521	18	5	1898	5	TNRC18	7	5354614	Splice_Site	SNP	C	TCGA-26-1442-01A-01D-1696-08		5354614	153784049	21	12335											
OGDH	4967	broad.mit.edu	37	chr7	44747273	44747273	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caggaggagcacaagaaccaAggctactatgactacgtgaa	11	9	0	3			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr7:44747273A>G	uc003tln.2	+	22	2998	c.2889A>G	c.(2887-2889)CAA>CAG	p.Q963Q	OGDH_uc011kbx.1_Silent_p.Q959Q|OGDH_uc011kby.1_Silent_p.Q813Q|OGDH_uc003tlp.2_Silent_p.Q974Q|OGDH_uc011kbz.1_Silent_p.Q758Q	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	963					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	ACAAGAACCAAGGCTACTATG	0.592													G	44747273	G	G	44747273	2	3	173	1	0	0	0	0	0	0	0	1	10839	69	3	4		4	OGDH	7	44747273	Silent	SNP	A	TCGA-26-1442-01A-01D-1696-08	39392659	44747273	114391390	22	12336											
ERLIN2	11160	broad.mit.edu	37	chr8	37611537	37611537	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctaacatgttcatggactcTgcgggcagtgtgagcaagca	12	10	2	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr8:37611537T>C	uc003xke.3	+	12	1039	c.924T>C	c.(922-924)TCT>TCC	p.S308S		NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	308	Interaction with ERLIN1.|Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TCATGGACTCTGCGGGCAGTG	0.463													C	37611537	C	C	37611537	2	2	173	1	0	0	0	0	0	0	0	1	5233	1567	55	4		4	ERLIN2	8	37611537	Silent	SNP	T	TCGA-26-1442-01A-01D-1696-08		37611537	108752485	23	12337											
LAPTM4B	55353	broad.mit.edu	37	chr8	98863639	98863639	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcaggtgctgctacccccGtatgatgatgccactgtgaa	10	12	1	3	rs147233429		TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr8:98863639G>A	uc003yia.2	+	7	1047	c.891G>A	c.(889-891)CCG>CCA	p.P297P	LAPTM4B_uc010mbg.2_Silent_p.P129P	NM_018407	NP_060877	Q86VI4	LAP4B_HUMAN	lysosomal associated transmembrane protein 4	350					transport	endomembrane system|integral to membrane	protein binding			skin(1)	1	Breast(36;1.59e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.149)			TGCTACCCCCGTATGATGATG	0.527													A	98863639	A	A	98863639	2	1	173	1	0	0	0	0	0	0	0	1	8625	1132	40	1		1	LAPTM4B	8	98863639	Silent	SNP	G	TCGA-26-1442-01A-01D-1696-08	61252102	98863639	47500383	24	12338											
C9orf79	286234	broad.mit.edu	37	chr9	90499950	90499950	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcatgggaaatgcatgcaagAtccgtctcctgccagcttgt	11	11	1	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr9:90499950A>G	uc004app.3	+	4	583	c.548A>G	c.(547-549)GAT>GGT	p.D183G	C9orf79_uc004apo.1_Intron	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	183	Pro-rich.					integral to membrane				ovary(3)	3						TGCATGCAAGATCCGTCTCCT	0.627													G	90499950	G	G	90499950	3	3	173	1	0	0	0	0	1	0	0	0	2497	333	12	4	562	4	C9orf79	9	90499950	Missense_Mutation	SNP	A	TCGA-26-1442-01A-01D-1696-08		90499950	50713481	25	12339											
AK1	203	broad.mit.edu	37	chr9	130630690	130630691	+	Frame_Shift_Ins	INS	-	T	T													gctttttgatggtctcctcaINSttgtcgtccacacgcccgct							TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr9:130630690_130630691insT	uc004bsm.3	-	6	578_579	c.425_426insA	c.(424-426)AATfs	p.N142fs		NM_000476	NP_000467	P00568	KAD1_HUMAN	adenylate kinase 1	142					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding				0						TGGTCTCCTCATTGTCGTCCAC	0.574													T	130630691	T	T	130630690	7	5	173	1	0	1	1	0	0	0	0	0	439	214	8	0	166	0	AK1	9	130630690	Frame_Shift_Ins	INS	-	TCGA-26-1442-01A-01D-1696-08	40130740	130630690	10582741	26	12340											
DLG5	9231	broad.mit.edu	37	chr10	79581222	79581222	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgggggtgtcagaggccccGccctcttggagggctgggga	19	10	2	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr10:79581222G>A	uc001jzk.2	-	15	3090	c.3020C>T	c.(3019-3021)GCG>GTG	p.A1007V	DLG5_uc001jzi.2_5'Flank|DLG5_uc001jzj.2_Intron|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.A611V	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1007	Pro-rich.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CAGAGGCCCCGCCCTCTTGGA	0.592													A	79581222	A	A	79581222	3	1	173	1	0	0	0	0	1	0	0	0	4558	1087	38	1	2811	1	DLG5	10	79581222	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08		79581222	55953525	27	12341											
CDHR1	92211	broad.mit.edu	37	chr10	85972090	85972090	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatcacactgctggatgtcaAtgaccacccccctcagtttg	7	14	3	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr10:85972090A>G	uc001kcv.2	+	15	1709	c.1709A>G	c.(1708-1710)AAT>AGT	p.N570S	CDHR1_uc001kcw.2_Missense_Mutation_p.N570S|CDHR1_uc009xst.2_Missense_Mutation_p.N274S|CDHR1_uc001kcx.2_5'Flank	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	570	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						CTGGATGTCAATGACCACCCC	0.522													G	85972090	G	G	85972090	3	3	173	1	0	0	0	0	1	0	0	0	3118	101	4	4	1767	4	CDHR1	10	85972090	Missense_Mutation	SNP	A	TCGA-26-1442-01A-01D-1696-08	6390868	85972090	49562657	28	12342											
TRPM5	29850	broad.mit.edu	37	chr11	2434731	2434731	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgatgaggttggtatagaCgagggcggggcagaggaagg	22	3	0	4	rs149949624	byFrequency	TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr11:2434731C>T	uc001lwm.3	-	13	1987	c.1978G>A	c.(1978-1980)GTC>ATC	p.V660I	TRPM5_uc010qxl.1_Missense_Mutation_p.V660I|TRPM5_uc009ydn.2_Missense_Mutation_p.V662I	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	660	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TTGGTATAGACGAGGGCGGGG	0.677													T	2434731	T	T	2434731	3	4	173	1	0	0	0	0	1	0	0	0	16586	536	19	1	1567	1	TRPM5	11	2434731	Missense_Mutation	SNP	C	TCGA-26-1442-01A-01D-1696-08		2434731	132571785	29	12343											
OR52B6	340980	broad.mit.edu	37	chr11	5602310	5602310	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	aatggcatcctaatttgtgtCatcctctcccaggcaatcct	6	13	2	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr11:5602310C>A	uc010qzi.1	+	1	204	c.204C>A	c.(202-204)GTC>GTA	p.V68V	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	68	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAATTTGTGTCATCCTCTCCC	0.522													A	5602310	A	A	5602310	2	1	173	1	0	0	0	0	0	0	0	1	11113	813	29	5		5	OR52B6	11	5602310	Silent	SNP	C	TCGA-26-1442-01A-01D-1696-08	3167579	5602310	129404206	30	12344											
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5656037	5656037	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cagaagcagttggtgagagaGctcatctcagatgtggagtg	15	6	2	4			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr11:5656037G>T	uc001mbf.2	+	10	2002	c.1758G>T	c.(1756-1758)GAG>GAT	p.E586D	HBG2_uc001mak.1_Intron|TRIM34_uc001mbh.2_Missense_Mutation_p.E232D|TRIM34_uc009yeq.2_5'UTR|TRIM34_uc001mbi.2_Missense_Mutation_p.E232D|TRIM34_uc001mbj.2_Missense_Mutation_p.E232D	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	586						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		TGGTGAGAGAGCTCATCTCAG	0.488													T	5656037	T	T	5656037	3	4	173	1	0	0	0	0	1	0	0	0	16531	962	34	5	1796	5	TRIM6-TRIM34	11	5656037	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	53727	5656037	129350479	31	12345											
MRVI1	10335	broad.mit.edu	37	chr11	10673684	10673684	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacgtgtgcccggaacctccGctgcgtcagccccaaagatg	11	16	1	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr11:10673684G>A	uc010rcc.1	-	2	499	c.113C>T	c.(112-114)GCG>GTG	p.A38V	MRVI1_uc001miw.2_Missense_Mutation_p.A29V|MRVI1_uc010rcb.1_Missense_Mutation_p.A29V|MRVI1_uc009ygb.1_5'UTR|MRVI1_uc001mix.2_5'UTR|MRVI1_uc001miz.2_Intron|MRVI1_uc009ygc.1_Intron|MRVI1_uc010rcd.1_Missense_Mutation_p.A38V|MRVI1_uc009ygd.1_Intron	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	29					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CGGAACCTCCGCTGCGTCAGC	0.647													A	10673684	A	A	10673684	3	1	173	1	0	0	0	0	1	0	0	0	9853	1087	38	1	2705	1	MRVI1	11	10673684	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	5017647	10673684	124332832	32	12346											
MS4A8B	83661	broad.mit.edu	37	chr11	60470903	60470903	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcctcggctccatcatggCgacggttctcgtaggggaat	14	12	2	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr11:60470903C>T	uc001npv.2	+	3	475	c.272C>T	c.(271-273)GCG>GTG	p.A91V	MS4A8B_uc009yne.1_Missense_Mutation_p.A91V	NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	91	Helical; (Potential).					integral to membrane	receptor activity				0						TCCATCATGGCGACGGTTCTC	0.552													T	60470903	T	T	60470903	3	4	173	1	0	0	0	0	1	0	0	0	9867	768	27	1	278	1	MS4A8B	11	60470903	Missense_Mutation	SNP	C	TCGA-26-1442-01A-01D-1696-08	49797219	60470903	74535613	33	12347											
HRASLS5	117245	broad.mit.edu	37	chr11	63257740	63257740	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctggatgcttctgccctgttCtaatgtgcccggcggaggct	13	12	2	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr11:63257740C>G	uc001nwy.2	-	2	418	c.244G>C	c.(244-246)GAA>CAA	p.E82Q	HRASLS5_uc001nwz.2_Missense_Mutation_p.E72Q|HRASLS5_uc010rmq.1_Missense_Mutation_p.E82Q|HRASLS5_uc009yos.2_RNA	NM_054108	NP_473449	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5 isoform 1	82										ovary(1)	1						CTGCCCTGTTCTAATGTGCCC	0.498													G	63257740	G	G	63257740	3	3	173	1	0	0	0	0	1	0	0	0	7351	922	32	5	615	5	HRASLS5	11	63257740	Missense_Mutation	SNP	C	TCGA-26-1442-01A-01D-1696-08	2786837	63257740	71748776	34	12348											
PFKM	5213	broad.mit.edu	37	chr12	48529142	48529142	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgtgcagaggggtgggacGccatcagcctttgacagaat	14	9	1	3			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr12:48529142G>A	uc001rrc.2	+	10	1082	c.912G>A	c.(910-912)ACG>ACA	p.T304T	PFKM_uc001rra.1_5'UTR|PFKM_uc001rrb.1_Silent_p.T375T|PFKM_uc001rrd.2_5'UTR|PFKM_uc001rre.1_Silent_p.T304T|PFKM_uc001rrg.1_Intron	NM_000289	NP_000280	P08237	K6PF_HUMAN	phosphofructokinase, muscle	304					fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4						GGGGTGGGACGCCATCAGCCT	0.572													A	48529142	A	A	48529142	2	1	173	1	0	0	0	0	0	0	0	1	11765	1074	38	1		1	PFKM	12	48529142	Silent	SNP	G	TCGA-26-1442-01A-01D-1696-08		48529142	85322753	35	12349											
ESPL1	9700	broad.mit.edu	37	chr12	53663316	53663316	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tgcttctccaacagcctgtcGagcggtagctgcccatcagc	10	15	2	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr12:53663316G>T	uc001sck.2	+	3	681	c.590G>T	c.(589-591)CGA>CTA	p.R197L	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	197					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						ACAGCCTGTCGAGCGGTAGCT	0.517													T	53663316	T	T	53663316	3	4	173	1	0	0	0	0	1	0	0	0	5253	1058	37	5	596	5	ESPL1	12	53663316	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	5134174	53663316	80188579	36	12350											
SP1	6667	broad.mit.edu	37	chr12	53804896	53804896	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgccactccttcagcccttAttaccaccaatatggtagcc	5	16	1	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr12:53804896A>T	uc001scw.2	+	6	2327	c.2230A>T	c.(2230-2232)ATT>TTT	p.I744F	SP1_uc010sog.1_Missense_Mutation_p.I737F	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	744	Domain D.|VZV IE62-binding.				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		TTCAGCCCTTATTACCACCAA	0.572													T	53804896	T	T	53804896	3	4	173	1	0	0	0	0	1	0	0	0	14959	449	16	5	2252	5	SP1	12	53804896	Missense_Mutation	SNP	A	TCGA-26-1442-01A-01D-1696-08	141580	53804896	80046999	37	12351											
ITGA7	3679	broad.mit.edu	37	chr12	56087909	56087909	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgctggggaatggccattcTggcgtggagaggtcagaaca	16	7	2	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr12:56087909T>C	uc001shh.2	-	19	2665	c.2445_splice	c.e19-1	p.G815_splice	ITGA7_uc001shg.2_Splice_Site_p.G811_splice|ITGA7_uc010sps.1_Splice_Site_p.G718_splice|ITGA7_uc009znw.2_Splice_Site_p.G58_splice|ITGA7_uc009znx.2_Splice_Site_p.G692_splice	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor						cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						ATGGCCATTCTGGCGTGGAGA	0.592													C	56087909	C	C	56087909	5	2	173	1	0	0	0	0	0	0	1	0	7881	1594	55	4	1010	4	ITGA7	12	56087909	Splice_Site	SNP	T	TCGA-26-1442-01A-01D-1696-08	2283013	56087909	77763986	38	12352											
MTERFD3	80298	broad.mit.edu	37	chr12	107372183	107372183	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttggactacagacaattgCttccgggcagcgttccaaaa	11	10	0	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr12:107372183C>T	uc001tme.1	-	2	2129	c.310G>A	c.(310-312)GCA>ACA	p.A104T	MTERFD3_uc001tmf.1_Missense_Mutation_p.A104T|MTERFD3_uc001tmg.1_Missense_Mutation_p.A104T|MTERFD3_uc001tmh.1_Missense_Mutation_p.A104T	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						CAGACAATTGCTTCCGGGCAG	0.423													T	107372183	T	T	107372183	3	4	173	1	0	0	0	0	1	0	0	0	9921	797	28	3	851	3	MTERFD3	12	107372183	Missense_Mutation	SNP	C	TCGA-26-1442-01A-01D-1696-08	51284274	107372183	26479712	39	12353											
EIF2B1	1967	broad.mit.edu	37	chr12	124116941	124116941	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtccggatggcagccactgcTgaggccatgtcaggatcttc	13	12	2	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr12:124116941T>C	uc001ufm.2	-	2	209	c.66A>G	c.(64-66)TCA>TCG	p.S22S	GTF2H3_uc001ufo.1_5'Flank|GTF2H3_uc010tau.1_5'Flank|EIF2B1_uc001ufn.2_Silent_p.S22S|EIF2B1_uc010tat.1_Silent_p.S22S	NM_001414	NP_001405	Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B,	22					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		CAGCCACTGCTGAGGCCATGT	0.398													C	124116941	C	C	124116941	2	2	173	1	0	0	0	0	0	0	0	1	5000	1567	55	4		4	EIF2B1	12	124116941	Silent	SNP	T	TCGA-26-1442-01A-01D-1696-08	16744758	124116941	9734954	40	12354											
FZD10	11211	broad.mit.edu	37	chr12	130648643	130648643	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctcaccggggtctgctacGtgggcagcatggacgtcaac	14	12	3	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr12:130648643G>A	uc001uii.2	+	1	1612	c.1156G>A	c.(1156-1158)GTG>ATG	p.V386M	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	386	Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GGTCTGCTACGTGGGCAGCAT	0.657													A	130648643	A	A	130648643	3	1	173	1	0	0	0	0	1	0	0	0	6129	1145	40	1	1158	1	FZD10	12	130648643	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	6531702	130648643	3203252	41	12355											
C13orf26	122046	broad.mit.edu	37	chr13	31531137	31531137	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaatcagtttatttcccttaCtaagagagactttgtggaca	7	7	1	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr13:31531137C>G	uc001uti.2	+	4	459	c.440C>G	c.(439-441)ACT>AGT	p.T147S		NM_152325	NP_689538	Q8N6G2	CM026_HUMAN	hypothetical protein LOC122046	147										ovary(2)|skin(1)	3		Lung SC(185;0.0281)		all cancers(112;0.0176)|Epithelial(112;0.0768)|OV - Ovarian serous cystadenocarcinoma(117;0.0852)		ATTTCCCTTACTAAGAGAGAC	0.318													G	31531137	G	G	31531137	3	3	173	1	0	0	0	0	1	0	0	0	1722	565	20	5	454	5	C13orf26	13	31531137	Missense_Mutation	SNP	C	TCGA-26-1442-01A-01D-1696-08		31531137	83638741	42	12356											
SLC15A1	6564	broad.mit.edu	37	chr13	99378425	99378425	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taagagctccgagaattggcGtcaggtagcacagagccaca	12	10	1	3			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr13:99378425G>A	uc001vno.2	-	4	274	c.197C>T	c.(196-198)ACG>ATG	p.T66M	SLC15A1_uc001vnp.1_Missense_Mutation_p.T34M	NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	66	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	GAGAATTGGCGTCAGGTAGCA	0.463													A	99378425	A	A	99378425	3	1	173	1	0	0	0	0	1	0	0	0	14398	1145	40	1	2009	1	SLC15A1	13	99378425	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	67847288	99378425	15791453	43	12357											
CHD8	57680	broad.mit.edu	37	chr14	21870120	21870120	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	catagacagaacatgccttaGcaaaggtggaaccttttcct	8	10	0	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr14:21870120G>C	uc001was.1	-	20	3315	c.3221C>G	c.(3220-3222)GCT>GGT	p.A1074G	CHD8_uc001war.1_Missense_Mutation_p.A970G|CHD8_uc001wav.1_Missense_Mutation_p.A516G	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1353					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ACATGCCTTAGCAAAGGTGGA	0.353													C	21870120	C	C	21870120	3	2	173	1	0	0	0	0	1	0	0	0	3331	971	34	5	3763	5	CHD8	14	21870120	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08		21870120	85479420	44	12358											
NYNRIN	57523	broad.mit.edu	37	chr14	24878580	24878580	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggaagcccgtggctcaagGggggctgacagatcagtcag	17	9	3	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr14:24878580G>A	uc001wpf.3	+	4	1898	c.1580G>A	c.(1579-1581)GGG>GAG	p.G527E		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	527					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GTGGCTCAAGGGGGGCTGACA	0.567													A	24878580	A	A	24878580	3	1	173	1	0	0	0	0	1	0	0	0	10796	1232	43	3	1590	3	NYNRIN	14	24878580	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	3008460	24878580	82470960	45	12359											
FRMD6	122786	broad.mit.edu	37	chr14	52194629	52194629	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatgaggaaggcctctattGcaacagttgcttggcccagc	13	10	1	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr14:52194629G>A	uc001wzd.2	+	14	2036	c.1751G>A	c.(1750-1752)TGC>TAC	p.C584Y	FRMD6_uc001wzb.2_Missense_Mutation_p.C576Y|FRMD6_uc001wzc.2_Missense_Mutation_p.C576Y|FRMD6_uc001wze.2_Missense_Mutation_p.C507Y|FRMD6_uc001wzf.2_Missense_Mutation_p.C277Y|FRMD6_uc001wzg.2_Missense_Mutation_p.C226Y	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	584						cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					GGCCTCTATTGCAACAGTTGC	0.468													A	52194629	A	A	52194629	3	1	173	1	0	0	0	0	1	0	0	0	6054	1319	46	3	1777	3	FRMD6	14	52194629	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	27316049	52194629	55154911	46	12360											
SYNE2	23224	broad.mit.edu	37	chr14	64540771	64540771	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcacaaaagagataattgctTtgaagaatttctttcaacag	6	6	3	3			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr14:64540771T>C	uc001xgm.2	+	53	11013	c.10783T>C	c.(10783-10785)TTG>CTG	p.L3595L	SYNE2_uc001xgl.2_Silent_p.L3595L|SYNE2_uc010apy.2_5'Flank|SYNE2_uc010apw.1_Silent_p.L301L|SYNE2_uc010apx.1_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3595	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GATAATTGCTTTGAAGAATTT	0.358													C	64540771	C	C	64540771	2	2	173	1	0	0	0	0	0	0	0	1	15443	1838	64	4		4	SYNE2	14	64540771	Silent	SNP	T	TCGA-26-1442-01A-01D-1696-08	12346142	64540771	42808769	47	12361											
TUBGCP5	114791	broad.mit.edu	37	chr15	22835924	22835924	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtctttaatagatttcatcGtttcttggatgtcaacagcc	7	8	4	1	rs143778036		TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr15:22835924G>T	uc001yur.3	+	2	285	c.155G>T	c.(154-156)CGT>CTT	p.R52L	TUBGCP5_uc001yuq.2_Missense_Mutation_p.R52L	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	52					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		AGATTTCATCGTTTCTTGGAT	0.368													T	22835924	T	T	22835924	3	4	173	1	0	0	0	0	1	0	0	0	16766	1145	40	5	161	5	TUBGCP5	15	22835924	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08		22835924	79695468	48	12362											
KCTD19	146212	broad.mit.edu	37	chr16	67331487	67331487	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggctcgtaggtgatgtcccTtttgtctaggaaggcacaga	13	8	1	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr16:67331487T>C	uc002esu.2	-	7	1117	c.1066A>G	c.(1066-1068)AGG>GGG	p.R356G	KCTD19_uc002est.2_Missense_Mutation_p.R128G|KCTD19_uc010vjj.1_Missense_Mutation_p.R99G	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	356						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GTGATGTCCCTTTTGTCTAGG	0.517													C	67331487	C	C	67331487	3	2	173	1	0	0	0	0	1	0	0	0	8106	1608	56	4	1754	4	KCTD19	16	67331487	Missense_Mutation	SNP	T	TCGA-26-1442-01A-01D-1696-08		67331487	23023266	49	12363											
TP53	7157	broad.mit.edu	37	chr17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccaggacaggcacaaacacGcacctcaaagctgttccgtc	8	16	1	0	rs121913343		TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577121	A	A	7577121	3	1	173	1	0	0	0	0	1	0	0	0	16378	1087	38	1	469	1	TP53	17	7577121	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08		7577121	73618089	50	12364											
DNAH9	1770	broad.mit.edu	37	chr17	11696846	11696846	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcttctcctcagtggaatgTgtgaaatccacatgggatct	9	10	4	1			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr17:11696846T>C	uc002gne.2	+	42	8156	c.8088T>C	c.(8086-8088)TGT>TGC	p.C2696C	DNAH9_uc010coo.2_Silent_p.C1990C	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2696					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAGTGGAATGTGTGAAATCCA	0.388													C	11696846	C	C	11696846	2	2	173	1	0	0	0	0	0	0	0	1	4608	1702	59	4		4	DNAH9	17	11696846	Silent	SNP	T	TCGA-26-1442-01A-01D-1696-08	4119725	11696846	69498364	51	12365											
BPTF	2186	broad.mit.edu	37	chr17	65862640	65862640	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tattacagcacaaaggtccaActtgcagaattaattgactg	7	8	0	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr17:65862640A>G	uc002jgf.2	+	3	1558	c.1497A>G	c.(1495-1497)CAA>CAG	p.Q499Q	BPTF_uc002jge.2_Silent_p.Q499Q|BPTF_uc010wqm.1_Silent_p.Q499Q	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	499					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAAAGGTCCAACTTGCAGAAT	0.343													G	65862640	G	G	65862640	2	3	173	1	0	0	0	0	0	0	0	1	1495	40	2	4		4	BPTF	17	65862640	Silent	SNP	A	TCGA-26-1442-01A-01D-1696-08	54165794	65862640	15332570	52	12366											
MIB1	57534	broad.mit.edu	37	chr18	19321653	19321653	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acggcggcgagggccatgtgGgcaccgtccggagcttcgag	18	12	0	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr18:19321653G>C	uc002ktq.2	+	1	109	c.109G>C	c.(109-111)GGC>CGC	p.G37R	MIB1_uc002ktp.2_Intron	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	37	MIB/HERC2 1.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			GGGCCATGTGGGCACCGTCCG	0.677													C	19321653	C	C	19321653	3	2	173	1	0	0	0	0	1	0	0	0	9566	1232	43	5	111	5	MIB1	18	19321653	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08		19321653	58755595	53	12367											
SOCS6	9306	broad.mit.edu	37	chr18	67992496	67992496	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaagagctcggcttctcatAatggagacctgcatcttcac	9	11	3	3			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr18:67992496A>G	uc002lkr.1	+	2	908	c.592A>G	c.(592-594)AAT>GAT	p.N198D	SOCS6_uc010dqq.2_Missense_Mutation_p.N198D	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	198					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				GGCTTCTCATAATGGAGACCT	0.512													G	67992496	G	G	67992496	3	3	173	1	0	0	0	0	1	0	0	0	14918	362	13	4	594	4	SOCS6	18	67992496	Missense_Mutation	SNP	A	TCGA-26-1442-01A-01D-1696-08	48670843	67992496	10084752	54	12368											
LMNB2	84823	broad.mit.edu	37	chr19	2444529	2444529	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgactcgtacagcgccttgaTgccactcacctggggagacc	11	15	1	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr19:2444529T>C	uc002lvy.2	-	2	301	c.214A>G	c.(214-216)ATC>GTC	p.I72V	LMNB2_uc002lwa.1_Missense_Mutation_p.I92V	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	72	Rod.|Linker 1.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCGCCTTGATGCCACTCACC	0.642													C	2444529	C	C	2444529	3	2	173	1	0	0	0	0	1	0	0	0	8850	1464	51	4	1632	4	LMNB2	19	2444529	Missense_Mutation	SNP	T	TCGA-26-1442-01A-01D-1696-08		2444529	56684454	55	12369											
PGLS	25796	broad.mit.edu	37	chr19	17626983	17626983	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccctctgttggctgcagaCgcatcttctctccagactgc	9	15	3	2	rs143569199		TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr19:17626983C>T	uc002ngw.2	+	2	340	c.290C>T	c.(289-291)ACG>ATG	p.T97M		NM_012088	NP_036220	O95336	6PGL_HUMAN	6-phosphogluconolactonase	97						cytosol	6-phosphogluconolactonase activity				0						TGGCTGCAGACGCATCTTCTC	0.433													T	17626983	T	T	17626983	3	4	173	1	0	0	0	0	1	0	0	0	11792	550	19	1	296	1	PGLS	19	17626983	Missense_Mutation	SNP	C	TCGA-26-1442-01A-01D-1696-08	15182454	17626983	41502000	56	12370											
ZNF233	353355	broad.mit.edu	37	chr19	44778066	44778066	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	acaacttcaagcccatcagaGaggtcactctagagacaaga	8	11	4	3			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr19:44778066G>A	uc002oyz.1	+	5	1380	c.1253G>A	c.(1252-1254)AGA>AAA	p.R418K	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.R233K	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	418	C2H2-type 5; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				GCCCATCAGAGAGGTCACTCT	0.418													A	44778066	A	A	44778066	3	1	173	1	0	0	0	0	1	0	0	0	17783	942	33	3	1267	3	ZNF233	19	44778066	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08	27151083	44778066	14350917	57	12371											
PEG3	5178	broad.mit.edu	37	chr19	57328400	57328400	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctctagtatgcatgatctgGtgctcaacaaattctgagat	8	8	4	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr19:57328400G>A	uc002qnu.2	-	7	1761	c.1410C>T	c.(1408-1410)CAC>CAT	p.H470H	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.H441H|PEG3_uc002qnv.2_Silent_p.H470H|PEG3_uc002qnw.2_Silent_p.H346H|PEG3_uc002qnx.2_Silent_p.H344H|PEG3_uc010etr.2_Silent_p.H470H	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	470	C2H2-type 1.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCATGATCTGGTGCTCAACAA	0.458													A	57328400	A	A	57328400	2	1	173	1	0	0	0	0	0	0	0	1	11720	1252	44	3		3	PEG3	19	57328400	Silent	SNP	G	TCGA-26-1442-01A-01D-1696-08	12550334	57328400	1800583	58	12372											
ACOT8	10005	broad.mit.edu	37	chr20	44477248	44477248	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgcacggccttcacagagCgcaccgagaagctcgaccct	11	15	1	2			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chr20:44477248C>T	uc002xqa.1	-	3	410	c.329G>A	c.(328-330)CGC>CAC	p.R110H	ACOT8_uc010zxe.1_Missense_Mutation_p.R110H|ACOT8_uc002xqc.1_Missense_Mutation_p.R57H|ACOT8_uc010zxf.1_Intron	NM_005469	NP_005460	O14734	ACOT8_HUMAN	peroxisomal acyl-CoA thioesterase 1 isoform a	110					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|interspecies interaction between organisms|peroxisome organization	peroxisomal matrix	acetyl-CoA hydrolase activity|acyl-CoA thioesterase activity|carboxylesterase activity|choloyl-CoA hydrolase activity|protein binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CTTCACAGAGCGCACCGAGAA	0.627													T	44477248	T	T	44477248	3	4	173	1	0	0	0	0	1	0	0	0	156	768	27	1	646	1	ACOT8	20	44477248	Missense_Mutation	SNP	C	TCGA-26-1442-01A-01D-1696-08		44477248	18548272	59	12373											
KDM5C	8242	broad.mit.edu	37	chrX	53223866	53223866	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttggccgaattggtgcgacGcagctgcaggataccctcct	12	13	0	0			TCGA-26-1442-01A-01D-1696-08	TCGA-26-1442-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	17e25583-886e-4dc9-802b-35e67971073d	251ab65c-abbf-4357-902b-bb1f5070536d	g.chrX:53223866G>A	uc004drz.2	-	23	4026	c.3493C>T	c.(3493-3495)CGT>TGT	p.R1165C	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Missense_Mutation_p.R1098C|KDM5C_uc004dsa.2_Missense_Mutation_p.R1164C|uc004dsb.1_RNA	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	1165					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						TTGGTGCGACGCAGCTGCAGG	0.612			N|F|S		clear cell renal carcinoma								A	53223866	A	A	53223866	3	1	173	1	0	0	0	0	1	0	0	0	8135	1087	38	1	1303	1	KDM5C	23	53223866	Missense_Mutation	SNP	G	TCGA-26-1442-01A-01D-1696-08		53223866	102046694	60	12374											
DNAJC16	23341	broad.mit.edu	37	chr1	15873341	15873341	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtccttctgtttgaccaaaCgcccattgtgccactgttat	7	12	1	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr1:15873341C>T	uc001aws.2	+	6	959	c.839C>T	c.(838-840)ACG>ATG	p.T280M	DNAJC16_uc001awr.1_Missense_Mutation_p.T280M|DNAJC16_uc001awt.2_Translation_Start_Site	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	280	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TTTGACCAAACGCCCATTGTG	0.308													T	15873341	T	T	15873341	3	4	174	1	0	0	0	0	1	0	0	0	4635	536	19	1	857	1	DNAJC16	1	15873341	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08		15873341	233377280	1	12375											
MACF1	23499	broad.mit.edu	37	chr1	39907987	39907987	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggtgagaaaattgcccacCgacaggtaaggcaggtggta	15	7	0	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr1:39907987C>T	uc010oiu.1	+	41	14403	c.14272C>T	c.(14272-14274)CGA>TGA	p.R4758*	MACF1_uc010ois.1_Nonsense_Mutation_p.R4256*	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6323	Spectrin 12.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AATTGCCCACCGACAGGTAAG	0.443													T	39907987	T	T	39907987	4	4	174	1	0	0	0	0	0	1	0	0	9144	644	23	2	19203	2	MACF1	1	39907987	Nonsense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	24034646	39907987	209342634	2	12376											
KCNQ4	9132	broad.mit.edu	37	chr1	41284177	41284177	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgccgcccccgcccctgcagActtcatcgtgttcgtggcct	10	19	1	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr1:41284177A>G	uc001cgh.1	+	4	615	c.533A>G	c.(532-534)GAC>GGC	p.D178G	KCNQ4_uc001cgi.1_Missense_Mutation_p.D178G	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	178	Helical; Name=Segment S3; (Potential).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			GCCCCTGCAGACTTCATCGTG	0.701													G	41284177	G	G	41284177	3	3	174	1	0	0	0	0	1	0	0	0	8085	289	10	4	547	4	KCNQ4	1	41284177	Missense_Mutation	SNP	A	TCGA-26-5132-01A-01D-1486-08	1376190	41284177	207966444	3	12377											
MYSM1	114803	broad.mit.edu	37	chr1	59141202	59141202	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttctactgcatcttttctgtCtctgattcgtactttgtcaa	5	10	5	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr1:59141202C>T	uc009wab.1	-	10	1464	c.1441G>A	c.(1441-1443)GAC>AAC	p.D481N	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	481					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TCTTTTCTGTCTCTGATTCGT	0.408													T	59141202	T	T	59141202	3	4	174	1	0	0	0	0	1	0	0	0	10101	913	32	3	1089	3	MYSM1	1	59141202	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	17857025	59141202	190109419	4	12378											
GJA5	2702	broad.mit.edu	37	chr1	147230552	147230552	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaggcactgattaaagtcGgggggtggtgtgcagctctg	16	8	1	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr1:147230552G>A	uc001eps.1	-	2	936	c.795C>T	c.(793-795)CCC>CCT	p.P265P	GJA5_uc001ept.1_Silent_p.P265P	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	265	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			GATTAAAGTCGGGGGGTGGTG	0.532													A	147230552	A	A	147230552	2	1	174	1	0	0	0	0	0	0	0	1	6404	1103	39	2		2	GJA5	1	147230552	Silent	SNP	G	TCGA-26-5132-01A-01D-1486-08	88089350	147230552	102020069	5	12379											
PRPF3	9129	broad.mit.edu	37	chr1	150318611	150318611	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacgtggtagtagtggaaggGggtgagtctgaaaaacttga	16	3	1	3			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr1:150318611G>A	uc001eum.3	+	13	1920	c.1758G>A	c.(1756-1758)GGG>GGA	p.G586G	PRPF3_uc009wlp.2_RNA|PRPF3_uc010pca.1_Silent_p.G545G|PRPF3_uc010pcb.1_Silent_p.G537G|PRPF3_uc009wlq.1_RNA	NM_004698	NP_004689	O43395	PRPF3_HUMAN	PRP3 pre-mRNA processing factor 3 homolog	586					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			ovary(1)	1	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		TAGTGGAAGGGGGTGAGTCTG	0.488													A	150318611	A	A	150318611	2	1	174	1	0	0	0	0	0	0	0	1	12565	1246	43	3		3	PRPF3	1	150318611	Silent	SNP	G	TCGA-26-5132-01A-01D-1486-08	3088059	150318611	98932010	6	12380											
FAM5C	339479	broad.mit.edu	37	chr1	190234152	190234152	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctcgtttgctcaacttcCgcttgtccacaaaaattgtg	7	12	1	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr1:190234152C>T	uc001gse.1	-	4	693	c.461G>A	c.(460-462)CGG>CAG	p.R154Q	FAM5C_uc010pot.1_Missense_Mutation_p.R52Q	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	154						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GCTCAACTTCCGCTTGTCCAC	0.388													T	190234152	T	T	190234152	3	4	174	1	0	0	0	0	1	0	0	0	5594	652	23	2	1859	2	FAM5C	1	190234152	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	39915541	190234152	59016469	7	12381											
LYST	1130	broad.mit.edu	37	chr1	235922440	235922440	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgcaatagtgctgtggcttCgctggaaggaggccaatccc	13	10	0	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr1:235922440C>T	uc001hxj.2	-	23	6888	c.6713G>A	c.(6712-6714)CGA>CAA	p.R2238Q	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2238					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GCTGTGGCTTCGCTGGAAGGA	0.527									Chediak-Higashi_syndrome				T	235922440	T	T	235922440	3	4	174	1	0	0	0	0	1	0	0	0	9128	884	31	2	4816	2	LYST	1	235922440	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	45688288	235922440	13328181	8	12382											
FBXO41	150726	broad.mit.edu	37	chr2	73493658	73493658	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcccaggctggcgctgggcGtgctgccacagctgctgctg	17	14	0	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr2:73493658G>A	uc002sjb.1	-	3	1241	c.1241C>T	c.(1240-1242)ACG>ATG	p.T414M		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	353						intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						GGCGCTGGGCGTGCTGCCACA	0.692													A	73493658	A	A	73493658	3	1	174	1	0	0	0	0	1	0	0	0	5750	1145	40	1	1613	1	FBXO41	2	73493658	Missense_Mutation	SNP	G	TCGA-26-5132-01A-01D-1486-08		73493658	169705715	9	12383											
SCN7A	6332	broad.mit.edu	37	chr2	167328840	167328840	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tactcactcaaacacagttaCgctgaaatcgagccagttcc	6	13	2	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr2:167328840C>T	uc002udu.1	-	5	686	c.559G>A	c.(559-561)GTA>ATA	p.V187I	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	187	Helical; Name=S3 of repeat I; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AACACAGTTACGCTGAAATCG	0.338													T	167328840	T	T	167328840	3	4	174	1	0	0	0	0	1	0	0	0	13923	536	19	1	4573	1	SCN7A	2	167328840	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	93835182	167328840	75870533	10	12384											
DCLK3	85443	broad.mit.edu	37	chr3	36779849	36779850	+	Frame_Shift_Ins	INS	-	C	C													cttgctactgggttctggctINScccatttccccctcccccac							TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr3:36779849_36779850insC	uc003cgi.2	-	2	792_793	c.301_302insG	c.(301-303)GAGfs	p.E101fs		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	101						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						GGGTTCTGGCTCCCATTTCCCC	0.589													C	36779850	C	C	36779849	7	5	174	1	0	1	1	0	0	0	0	0	4293	1551	54	0	1660	0	DCLK3	3	36779849	Frame_Shift_Ins	INS	-	TCGA-26-5132-01A-01D-1486-08		36779849	161242581	11	12385											
SLCO2A1	6578	broad.mit.edu	37	chr3	133653573	133653573	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggtcagatgaggcctgccGccttctgcacgttgtactcc	13	13	2	2	rs142805553	byFrequency	TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr3:133653573G>A	uc003eqa.3	-	14	2190	c.1916C>T	c.(1915-1917)GCG>GTG	p.A639V	SLCO2A1_uc003eqb.3_Missense_Mutation_p.A563V	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	639	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						GAGGCCTGCCGCCTTCTGCAC	0.567													A	133653573	A	A	133653573	3	1	174	1	0	0	0	0	1	0	0	0	14726	1087	38	1	19	1	SLCO2A1	3	133653573	Missense_Mutation	SNP	G	TCGA-26-5132-01A-01D-1486-08	96873724	133653573	64368857	12	12386											
DNAJC19	131118	broad.mit.edu	37	chr3	180705861	180705861	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tacttgaggctccatatgctTcatggcttgcaaaacgtaac	8	10	1	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr3:180705861T>C	uc003fkt.2	-	3	219	c.79A>G	c.(79-81)AAG>GAG	p.K27E	DNAJC19_uc003fku.2_RNA	NM_145261	NP_660304	Q96DA6	TIM14_HUMAN	DnaJ homolog, subfamily C, member 19	27	Mitochondrial matrix (Potential).				genitalia development|protein folding|protein targeting to mitochondrion|transmembrane transport|visual perception	integral to membrane|mitochondrial inner membrane	heat shock protein binding				0	all_cancers(143;3.12e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-36)|OV - Ovarian serous cystadenocarcinoma(80;1.55e-22)			TCCATATGCTTCATGGCTTGC	0.388													C	180705861	C	C	180705861	3	2	174	1	0	0	0	0	1	0	0	0	4638	1792	62	4	287	4	DNAJC19	3	180705861	Missense_Mutation	SNP	T	TCGA-26-5132-01A-01D-1486-08	47052288	180705861	17316569	13	12387											
LGI2	55203	broad.mit.edu	37	chr4	25014080	25014080	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttggagttgaacgtatccaCtgaaaccgactggtagggta	12	8	0	2			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr4:25014080C>T	uc003grf.2	-	7	796	c.697G>A	c.(697-699)GTG>ATG	p.V233M		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	233	EAR 1.					extracellular region					0		Breast(46;0.173)				AACGTATCCACTGAAACCGAC	0.453													T	25014080	T	T	25014080	3	4	174	1	0	0	0	0	1	0	0	0	8752	565	20	3	948	3	LGI2	4	25014080	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08		25014080	166140196	14	12388											
DCHS2	54798	broad.mit.edu	37	chr4	155219629	155219629	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaaccactgttcccacttcaGcatcttctctcacagaggac	6	15	4	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr4:155219629G>T	uc003inw.2	-	18	4472	c.4472C>A	c.(4471-4473)GCT>GAT	p.A1491D		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1491	Cadherin 13.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCCCACTTCAGCATCTTCTCT	0.463													T	155219629	T	T	155219629	3	4	174	1	0	0	0	0	1	0	0	0	4288	971	34	5	4310	5	DCHS2	4	155219629	Missense_Mutation	SNP	G	TCGA-26-5132-01A-01D-1486-08	130205549	155219629	35934647	15	12389											
SLC6A19	340024	broad.mit.edu	37	chr5	1214110	1214110	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacctggctggacgcgggcGcacaggtcttcttctccttc	11	15	3	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr5:1214110G>A	uc003jbw.3	+	6	873	c.817G>A	c.(817-819)GCA>ACA	p.A273T		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	273	Helical; Name=6; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGACGCGGGCGCACAGGTCTT	0.647													A	1214110	A	A	1214110	3	1	174	1	0	0	0	0	1	0	0	0	14682	1087	38	1	839	1	SLC6A19	5	1214110	Missense_Mutation	SNP	G	TCGA-26-5132-01A-01D-1486-08		1214110	179701150	16	12390											
ADAMTS12	81792	broad.mit.edu	37	chr5	33576573	33576573	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgtactttccactggagcGtcatttccaggtactctgat	8	11	3	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr5:33576573G>A	uc003jia.1	-	19	3721	c.3558C>T	c.(3556-3558)GAC>GAT	p.D1186D	ADAMTS12_uc010iuq.1_Silent_p.D1101D	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1186	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CCACTGGAGCGTCATTTCCAG	0.498										HNSCC(64;0.19)			A	33576573	A	A	33576573	2	1	174	1	0	0	0	0	0	0	0	1	257	1136	40	1		1	ADAMTS12	5	33576573	Silent	SNP	G	TCGA-26-5132-01A-01D-1486-08	32362463	33576573	147338687	17	12391											
HIST1H4G	8369	broad.mit.edu	37	chr6	26247188	26247188	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcccaaggccttttccggcCttgccccgaacagacatgat	8	15	0	2			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr6:26247188C>T	uc003nhf.2	-	1	18	c.18G>A	c.(16-18)AAG>AAA	p.K6K		NM_003547	NP_003538	Q99525	H4G_HUMAN	histone cluster 1, H4g	6					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				CTTTTCCGGCCTTGCCCCGAA	0.483													T	26247188	T	T	26247188	2	4	174	1	0	0	0	0	0	0	0	1	7171	680	24	3		3	HIST1H4G	6	26247188	Silent	SNP	C	TCGA-26-5132-01A-01D-1486-08		26247188	144867879	18	12392											
ZFP57	346171	broad.mit.edu	37	chr6	29641134	29641134	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggccggtaacccagatggaCgcggcggtgacgacttagtc	16	11	0	2			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr6:29641134C>T	uc011dlw.1	-	4	905	c.754G>A	c.(754-756)GTC>ATC	p.V252I	ZFP57_uc003nnl.3_Missense_Mutation_p.V232I	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	168	C2H2-type 3.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CCCAGATGGACGCGGCGGTGA	0.557													T	29641134	T	T	29641134	3	4	174	1	0	0	0	0	1	0	0	0	17648	536	19	1	860	1	ZFP57	6	29641134	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	3393946	29641134	141473933	19	12393											
TJAP1	93643	broad.mit.edu	37	chr6	43470020	43470020	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccttgtattatcccttttcaGgctgcagaacagctacacgg	8	12	1	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr6:43470020G>T	uc003ovd.2	+	7	667	c.291_splice	c.e7-1	p.R97_splice	TJAP1_uc003ovf.2_Splice_Site_p.R97_splice|TJAP1_uc003ove.2_Splice_Site_p.R97_splice|TJAP1_uc003ovc.2_Splice_Site_p.R97_splice|TJAP1_uc010jyp.2_Splice_Site_p.R56_splice|TJAP1_uc011dvh.1_Splice_Site_p.R97_splice|TJAP1_uc003ovg.2_Splice_Site|TJAP1_uc010jyq.2_Splice_Site_p.R97_splice|TJAP1_uc011dvi.1_Splice_Site_p.R97_splice|TJAP1_uc011dvj.1_Splice_Site|TJAP1_uc003ovi.2_Translation_Start_Site	NM_001146016	NP_001139488	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 isoform a							Golgi apparatus|tight junction	protein binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TCCCTTTTCAGGCTGCAGAAC	0.363													T	43470020	T	T	43470020	5	4	174	1	0	0	0	0	0	0	1	0	15925	1014	35	5	304	5	TJAP1	6	43470020	Splice_Site	SNP	G	TCGA-26-5132-01A-01D-1486-08	13828886	43470020	127645047	20	12394											
HDAC2	3066	broad.mit.edu	37	chr6	114264560	114264563	+	Frame_Shift_Del	DEL	CTTT	-	-													cttatcttcttcaattctagCtttctttgctcctttcttat							TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr6:114264560_114264563delCTTT	uc003pwd.1	-	12	1612_1615	c.1612_1615delAAAG	c.(1612-1617)AAAGCTfs	p.K538fs	HDAC2_uc003pwc.1_Frame_Shift_Del_p.K414fs|HDAC2_uc003pwe.1_Frame_Shift_Del_p.K414fs	NM_001527	NP_001518	Q92769	HDAC2_HUMAN	histone deacetylase 2	444_445					blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			skin(2)|ovary(1)|central_nervous_system(1)	4		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	tcaattctagctttctttgctcct	0.26													-	114264563	-	-	114264560	7	5	174	1	0	1	0	1	0	0	0	0	7007	797	28	0	145	0	HDAC2	6	114264560	Frame_Shift_Del	DEL	CTTT	TCGA-26-5132-01A-01D-1486-08	70794540	114264560	56850507	21	12395											
HEY2	23493	broad.mit.edu	37	chr6	126080793	126080793	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtccttcgcgggggcattcCccatgcttcccccaaacgca	9	17	0	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr6:126080793C>T	uc003qad.2	+	5	1050	c.859C>T	c.(859-861)CCC>TCC	p.P287S	HEY2_uc011ebr.1_Missense_Mutation_p.P241S	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	287	Ala-rich.				negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		GGGGGCATTCCCCATGCTTCC	0.667													T	126080793	T	T	126080793	3	4	174	1	0	0	0	0	1	0	0	0	7079	623	22	3	877	3	HEY2	6	126080793	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	11816233	126080793	45034274	22	12396											
HOXA6	3203	broad.mit.edu	37	chr7	27185435	27185435	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatctcgatgcggcggcgccGtgtcaggtagcggttgaagt	17	9	2	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr7:27185435G>A	uc003syo.1	-	2	544	c.544C>T	c.(544-546)CGG>TGG	p.R182W	HOXA5_uc003syn.1_5'Flank|uc003syp.1_5'Flank	NM_024014	NP_076919	P31267	HXA6_HUMAN	homeobox A6	182	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						CGGCGGCGCCGTGTCAGGTAG	0.602													A	27185435	A	A	27185435	3	1	174	1	0	0	0	0	1	0	0	0	7296	1144	40	1	161	1	HOXA6	7	27185435	Missense_Mutation	SNP	G	TCGA-26-5132-01A-01D-1486-08		27185435	131953228	23	12397											
CCDC132	55610	broad.mit.edu	37	chr7	92985271	92985271	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attggattttcaacagttttTaatgaaacttgaaaaactaa	5	4	1	2			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr7:92985271T>C	uc003umo.2	+	27	2782	c.2654T>C	c.(2653-2655)TTA>TCA	p.L885S	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.L855S|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.L605S	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	885											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			CAACAGTTTTTAATGAAACTT	0.303													C	92985271	C	C	92985271	3	2	174	1	0	0	0	0	1	0	0	0	2767	1764	61	4	2802	4	CCDC132	7	92985271	Missense_Mutation	SNP	T	TCGA-26-5132-01A-01D-1486-08	65799836	92985271	66153392	24	12398											
PEG10	23089	broad.mit.edu	37	chr7	94293142	94293142	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agttcgatggcaacccagacAtgctggctcctttcatggcc	10	13	1	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr7:94293142A>G	uc011kie.1	+	2	719	c.502A>G	c.(502-504)ATG>GTG	p.M168V		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	92	Necessary for interaction with ALK1.				apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CAACCCAGACATGCTGGCTCC	0.562													G	94293142	G	G	94293142	3	3	174	1	0	0	0	0	1	0	0	0	11719	217	8	4	508	4	PEG10	7	94293142	Missense_Mutation	SNP	A	TCGA-26-5132-01A-01D-1486-08	1307871	94293142	64845521	25	12399											
OR2AE1	81392	broad.mit.edu	37	chr7	99474406	99474406	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atttcttgccagataggtagTtggtagccatcttcaggatg	11	7	3	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr7:99474406T>C	uc003usc.1	-	1	251	c.251A>G	c.(250-252)AAC>AGC	p.N84S		NM_001005276	NP_001005276	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE,	84	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AGATAGGTAGTTGGTAGCCAT	0.468													C	99474406	C	C	99474406	3	2	174	1	0	0	0	0	1	0	0	0	10983	1725	60	4	724	4	OR2AE1	7	99474406	Missense_Mutation	SNP	T	TCGA-26-5132-01A-01D-1486-08	5181264	99474406	59664257	26	12400											
KRBA1	84626	broad.mit.edu	37	chr7	149431067	149431067	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccgagcagcctgctgggaggAgtgcagagggccctccagga	17	12	0	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr7:149431067A>T	uc003wfz.2	+	18	3423	c.3024A>T	c.(3022-3024)GGA>GGT	p.G1008G	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Silent_p.G615G	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	1008										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGCTGGGAGGAGTGCAGAGGG	0.647													T	149431067	T	T	149431067	2	4	174	1	0	0	0	0	0	0	0	1	8439	291	11	5		5	KRBA1	7	149431067	Silent	SNP	A	TCGA-26-5132-01A-01D-1486-08	49956661	149431067	9707596	27	12401											
ANK1	286	broad.mit.edu	37	chr8	41519452	41519452	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctatctgtcgaaccaccttgCgaatgatctaggaaaggaag	10	9	2	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr8:41519452C>T	uc003xok.2	-	41	5570	c.5486G>A	c.(5485-5487)CGC>CAC	p.R1829H	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.R983H|ANK1_uc003xoi.2_Missense_Mutation_p.R1829H|ANK1_uc003xoj.2_Missense_Mutation_p.R1829H|ANK1_uc003xol.2_Missense_Mutation_p.R1667H|ANK1_uc003xom.2_Missense_Mutation_p.R1870H|ANK1_uc011lcl.1_Missense_Mutation_p.R104H|ANK1_uc003xod.2_Missense_Mutation_p.R104H|ANK1_uc003xoc.2_Missense_Mutation_p.R104H|ANK1_uc003xof.2_Intron|MIR486_hsa-mir-486|MI0002470_5'Flank	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1829	55 kDa regulatory domain.			R->G: Abolishes interaction with OBSCN (in isoform Mu17).	axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AACCACCTTGCGAATGATCTA	0.423													T	41519452	T	T	41519452	3	4	174	1	0	0	0	0	1	0	0	0	620	768	27	1	270	1	ANK1	8	41519452	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08		41519452	104844570	28	12402											
SLC28A3	64078	broad.mit.edu	37	chr9	86917142	86917142	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccagaaccaatggctgtttAgaagccttctgccaggagac	11	11	1	3			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr9:86917142A>G	uc010mpz.2	-	5	622	c.497T>C	c.(496-498)CTA>CCA	p.L166P	SLC28A3_uc011lsy.1_Missense_Mutation_p.L97P|SLC28A3_uc004anu.1_Missense_Mutation_p.L166P|SLC28A3_uc010mqb.2_Missense_Mutation_p.L97P	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	166	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						ATGGCTGTTTAGAAGCCTTCT	0.433													G	86917142	G	G	86917142	3	3	174	1	0	0	0	0	1	0	0	0	14533	420	15	4	1634	4	SLC28A3	9	86917142	Missense_Mutation	SNP	A	TCGA-26-5132-01A-01D-1486-08		86917142	54296289	29	12403											
NAA35	60560	broad.mit.edu	37	chr9	88627995	88627995	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tattcagatccatggacataAcagggctcgacagagagata	10	8	1	3			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr9:88627995A>T	uc004aoi.3	+	16	1462	c.1325A>T	c.(1324-1326)AAC>ATC	p.N442I	NAA35_uc004aoj.3_Missense_Mutation_p.N442I	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	442					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						CATGGACATAACAGGGCTCGA	0.378													T	88627995	T	T	88627995	3	4	174	1	0	0	0	0	1	0	0	0	10123	43	2	5	1383	5	NAA35	9	88627995	Missense_Mutation	SNP	A	TCGA-26-5132-01A-01D-1486-08	1710853	88627995	52585436	30	12404											
SUSD3	203328	broad.mit.edu	37	chr9	95841846	95841846	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacttcaacaaacccgtgagCgggcccagccaggcgcacga	11	16	1	1	rs146086851	byFrequency	TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr9:95841846C>T	uc004atb.2	+	4	555	c.519C>T	c.(517-519)AGC>AGT	p.S173S	SUSD3_uc004atc.2_Silent_p.S160S	NM_145006	NP_659443	Q96L08	SUSD3_HUMAN	sushi domain containing 3	173	Cytoplasmic (Potential).					integral to membrane				breast(2)|skin(2)|ovary(1)|lung(1)	6						AACCCGTGAGCGGGCCCAGCC	0.642													T	95841846	T	T	95841846	2	4	174	1	0	0	0	0	0	0	0	1	15406	767	27	1		1	SUSD3	9	95841846	Silent	SNP	C	TCGA-26-5132-01A-01D-1486-08	7213851	95841846	45371585	31	12405											
DDX31	64794	broad.mit.edu	37	chr9	135470499	135470500	+	Splice_Site	DEL	CC	-	-													gtcttcttatgaaggtcaggCctgaagaacagtaacagcag							TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr9:135470499_135470500delCC	uc004cbq.1	-	20	2462	c.2310_splice	c.e20-1	p.R770_splice	DDX31_uc010mzu.1_Splice_Site_p.R697_splice	NM_022779	NP_073616	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31							nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		GAAGGTCAGGCCTGAAGAACAG	0.46													-	135470500	-	-	135470499	8	5	174	1	0	1	0	1	0	0	1	0	4356	753	26	0	249	0	DDX31	9	135470499	Splice_Site	DEL	CC	TCGA-26-5132-01A-01D-1486-08	39628653	135470499	5742932	32	12406											
HSPA14	51182	broad.mit.edu	37	chr10	14891809	14891809	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaagcaaaaaaatgctcttGggtaagtatatggggtttat	10	3	1	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr10:14891809G>A	uc001inf.2	+	6	607	c.466G>A	c.(466-468)GGA>AGA	p.G156R	HSPA14_uc010qbw.1_Missense_Mutation_p.G156R	NM_016299	NP_057383	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14 isoform 1	156					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5						AAATGCTCTTGGGTAAGTATA	0.338													A	14891809	A	A	14891809	3	1	174	1	0	0	0	0	1	0	0	0	7407	1362	47	3	488	3	HSPA14	10	14891809	Missense_Mutation	SNP	G	TCGA-26-5132-01A-01D-1486-08		14891809	120642938	33	12407											
PTEN	5728	broad.mit.edu	37	chr10	89720650	89720650	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttctttttttttttttttaGgacaaaatgtttcacttttg	4	4	2	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr10:89720650G>A	uc001kfb.2	+	9	1833	c.802_splice	c.e9-1	p.D268_splice		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(3)|p.N212fs*1(2)|p.Y27fs*1(2)|p.M264fs*8(2)|p.G165_*404del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		tttttttttAGGACAAAATGT	0.239		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89720650	A	A	89720650	5	1	174	1	0	0	0	0	0	0	1	0	12738	1014	35	3	831	3	PTEN	10	89720650	Splice_Site	SNP	G	TCGA-26-5132-01A-01D-1486-08	74828841	89720650	45814097	34	12408											
MUC2	4583	broad.mit.edu	37	chr11	1084747	1084747	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagcacctgcaagagaggaCgctgggtgtgcacccaggct	14	12	1	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr11:1084747C>T	uc001lsx.1	+	20	2569	c.2542C>T	c.(2542-2544)CGC>TGC	p.R848C		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	848						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CAAGAGAGGACGCTGGGTGTG	0.602													T	1084747	T	T	1084747	3	4	174	1	0	0	0	0	1	0	0	0	9975	536	19	1	2620	1	MUC2	11	1084747	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08		1084747	133921769	35	12409											
NELL1	4745	broad.mit.edu	37	chr11	21596532	21596532	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtacagaatggaagagtctgTtgttctgtggattttgagtg	14	3	2	3			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr11:21596532T>C	uc001mqe.2	+	20	2550	c.2397T>C	c.(2395-2397)TGT>TGC	p.C799C	NELL1_uc001mqf.2_Silent_p.C752C|NELL1_uc009yid.2_Silent_p.C827C|NELL1_uc010rdo.1_Silent_p.C742C|NELL1_uc010rdp.1_Silent_p.C512C|NELL1_uc001mqh.2_Silent_p.C344C	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	799	VWFC 5.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GAAGAGTCTGTTGTTCTGTGG	0.353													C	21596532	C	C	21596532	2	2	174	1	0	0	0	0	0	0	0	1	10333	1731	60	4		4	NELL1	11	21596532	Silent	SNP	T	TCGA-26-5132-01A-01D-1486-08	20511785	21596532	113409984	36	12410											
OR5D18	219438	broad.mit.edu	37	chr11	55587476	55587476	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtgatggcctatgaccgctTcgtggccatttgcaaccctc	10	13	0	2			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr11:55587476T>C	uc010rin.1	+	1	371	c.371T>C	c.(370-372)TTC>TCC	p.F124S		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TATGACCGCTTCGTGGCCATT	0.458													C	55587476	C	C	55587476	3	2	174	1	0	0	0	0	1	0	0	0	11157	1783	62	4	373	4	OR5D18	11	55587476	Missense_Mutation	SNP	T	TCGA-26-5132-01A-01D-1486-08	33990944	55587476	79419040	37	12411											
PANX3	116337	broad.mit.edu	37	chr11	124489386	124489386	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agaattcagctgctccatcaAgacagggctgctaagtgatg	11	9	2	3			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr11:124489386A>G	uc001qah.2	+	4	734	c.734A>G	c.(733-735)AAG>AGG	p.K245R		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	245	Extracellular (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		TGCTCCATCAAGACAGGGCTG	0.488													G	124489386	G	G	124489386	3	3	174	1	0	0	0	0	1	0	0	0	11422	72	3	4	748	4	PANX3	11	124489386	Missense_Mutation	SNP	A	TCGA-26-5132-01A-01D-1486-08	68901910	124489386	10517130	38	12412											
ABCC9	10060	broad.mit.edu	37	chr12	21995285	21995285	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtatttctggataaaataaaAggcaacaccaaggggcagga	11	6	1	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr12:21995285A>T	uc001rfi.1	-	27	3456	c.3436T>A	c.(3436-3438)TTT>ATT	p.F1146I	ABCC9_uc001rfh.2_Missense_Mutation_p.F1146I|ABCC9_uc001rfj.1_Missense_Mutation_p.F1110I	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1146	Helical; Name=14; (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ATAAAATAAAAGGCAACACCA	0.388													T	21995285	T	T	21995285	3	4	174	1	0	0	0	0	1	0	0	0	59	72	3	5	1403	5	ABCC9	12	21995285	Missense_Mutation	SNP	A	TCGA-26-5132-01A-01D-1486-08		21995285	111856610	39	12413											
ITPR2	3709	broad.mit.edu	37	chr12	26808744	26808744	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccattgtcagggcaaatttcCtcttcatatcatttctggaa	6	10	5	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr12:26808744C>T	uc001rhg.2	-	20	2903	c.2486G>A	c.(2485-2487)AGG>AAG	p.R829K		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	829	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					GGCAAATTTCCTCTTCATATC	0.313													T	26808744	T	T	26808744	3	4	174	1	0	0	0	0	1	0	0	0	7921	681	24	3	5771	3	ITPR2	12	26808744	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	4813459	26808744	107043151	40	12414											
ADAMTS20	80070	broad.mit.edu	37	chr12	43771195	43771195	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cattttccaactttccaagtGgccaaatgcaaacagctgtt	6	11	0	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr12:43771195G>C	uc010skx.1	-	32	4968	c.4968C>G	c.(4966-4968)GCC>GCG	p.A1656A		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1656	TSP type-1 15.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTTTCCAAGTGGCCAAATGCA	0.403													C	43771195	C	C	43771195	2	2	174	1	0	0	0	0	0	0	0	1	266	1335	47	5		5	ADAMTS20	12	43771195	Silent	SNP	G	TCGA-26-5132-01A-01D-1486-08	16962451	43771195	90080700	41	12415											
SUDS3	64426	broad.mit.edu	37	chr12	118841310	118841310	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agaagatggcaaactgtactAtgacaaaagatggtatgtta	10	4	0	4			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr12:118841310A>G	uc001twz.2	+	10	930	c.791A>G	c.(790-792)TAT>TGT	p.Y264C		NM_022491	NP_071936	Q9H7L9	SDS3_HUMAN	suppressor of defective silencing 3	264					chromatin modification|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	Sin3 complex	histone deacetylase binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAACTGTACTATGACAAAAGA	0.483													G	118841310	G	G	118841310	3	3	174	1	0	0	0	0	1	0	0	0	15366	449	16	4	829	4	SUDS3	12	118841310	Missense_Mutation	SNP	A	TCGA-26-5132-01A-01D-1486-08	75070115	118841310	15010585	42	12416											
RB1	5925	broad.mit.edu	37	chr13	48953730	48953730	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctttttgtttgtttgtagCgatacaaacttggagttcgc	9	6	1	0	rs3092891		TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr13:48953730C>T	uc001vcb.2	+	14	1499	c.1333C>T	c.(1333-1335)CGA>TGA	p.R445*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	445	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.R445*(2)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTTTGTAGCGATACAAACT	0.204		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	48953730	T	T	48953730	4	4	174	1	0	0	0	0	0	1	0	0	13098	782	27	1	1387	1	RB1	13	48953730	Nonsense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08		48953730	66216148	43	12417											
THBS1	7057	broad.mit.edu	37	chr15	39874516	39874516	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctttccgcatcgaggatGccaacctgatcccccctgtg	9	16	0	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr15:39874516G>A	uc001zkh.2	+	3	369	c.190G>A	c.(190-192)GCC>ACC	p.A64T		NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	64	TSP N-terminal.|Heparin-binding.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CATCGAGGATGCCAACCTGAT	0.612													A	39874516	A	A	39874516	3	1	174	1	0	0	0	0	1	0	0	0	15850	1319	46	3	196	3	THBS1	15	39874516	Missense_Mutation	SNP	G	TCGA-26-5132-01A-01D-1486-08		39874516	62656876	44	12418											
CDAN1	146059	broad.mit.edu	37	chr15	43022940	43022940	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccctcgctgcagcagagtcCgcacatccaggaccggaggg	14	15	0	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr15:43022940C>T	uc001zql.2	-	14	2147	c.2030G>A	c.(2029-2031)CGG>CAG	p.R677Q	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Missense_Mutation_p.G3R	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	677						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CAGCAGAGTCCGCACATCCAG	0.647													T	43022940	T	T	43022940	3	4	174	1	0	0	0	0	1	0	0	0	3054	652	23	2	1713	2	CDAN1	15	43022940	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	3148424	43022940	59508452	45	12419											
ZCCHC14	23174	broad.mit.edu	37	chr16	87448889	87448889	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acttcacactcacttttccaGctccagctgggtcttgagct	7	14	3	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr16:87448889G>T	uc002fjz.1	-	9	1084	c.1057C>A	c.(1057-1059)CTG>ATG	p.L353M	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.L129M	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	353					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CACTTTTCCAGCTCCAGCTGG	0.423													T	87448889	T	T	87448889	3	4	174	1	0	0	0	0	1	0	0	0	17580	962	34	5	1812	5	ZCCHC14	16	87448889	Missense_Mutation	SNP	G	TCGA-26-5132-01A-01D-1486-08		87448889	2905864	46	12420											
PRPF8	10594	broad.mit.edu	37	chr17	1577829	1577829	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctggaaactgagaaagtcaTttggcatctgagggggccca	13	9	2	2			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr17:1577829T>C	uc002fte.2	-	21	3320	c.3206A>G	c.(3205-3207)AAT>AGT	p.N1069S		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1069						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding	p.N1069D(1)		lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GAGAAAGTCATTTGGCATCTG	0.507													C	1577829	C	C	1577829	3	2	174	1	0	0	0	0	1	0	0	0	12575	1493	52	4	3893	4	PRPF8	17	1577829	Missense_Mutation	SNP	T	TCGA-26-5132-01A-01D-1486-08		1577829	79617381	47	12421											
ALDH3A1	218	broad.mit.edu	37	chr17	19644516	19644516	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttcatgaatttcccccaggCgatgcgtctgtgagaatccc	10	12	2	2	rs140108064	byFrequency	TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr17:19644516C>T	uc010cqu.2	-	5	1027	c.697G>A	c.(697-699)GCC>ACC	p.A233T	ALDH3A1_uc010vzd.1_Missense_Mutation_p.A233T|ALDH3A1_uc002gwj.2_Missense_Mutation_p.A233T|ALDH3A1_uc010cqv.2_Missense_Mutation_p.A233T|ALDH3A1_uc002gwk.2_Missense_Mutation_p.A350T|ALDH3A1_uc002gwl.1_Missense_Mutation_p.A160T	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	233					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	TTCCCCCAGGCGATGCGTCTG	0.537													T	19644516	T	T	19644516	3	4	174	1	0	0	0	0	1	0	0	0	497	768	27	1	688	1	ALDH3A1	17	19644516	Missense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	18066687	19644516	61550694	48	12422											
SEZ6	124925	broad.mit.edu	37	chr17	27287691	27287691	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cccattgcgaatgatgagccTgaaccaggagagtggcagct	13	10	0	4			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr17:27287691T>A	uc002hdp.2	-	7	1604	c.1410_splice	c.e7-1	p.R470_splice	SEZ6_uc002hdm.2_Splice_Site|SEZ6_uc010cry.1_Splice_Site_p.R470_splice|SEZ6_uc002hdq.1_Splice_Site_p.R345_splice	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1							integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			ATGATGAGCCTGAACCAGGAG	0.592													A	27287691	A	A	27287691	5	1	174	1	0	0	0	0	0	0	1	0	14142	1594	55	5	1633	5	SEZ6	17	27287691	Splice_Site	SNP	T	TCGA-26-5132-01A-01D-1486-08	7643175	27287691	53907519	49	12423											
KRT9	3857	broad.mit.edu	37	chr17	39724628	39724628	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gtcttccaagctcttctccaGagctgctttctaagggttag	9	11	4	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr17:39724628G>A	uc002hxe.3	-	6	1246	c.1180C>T	c.(1180-1182)CTG>TTG	p.L394L	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	394	Rod.|Coil 2.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				CTCTTCTCCAGAGCTGCTTTC	0.532													A	39724628	A	A	39724628	2	1	174	1	0	0	0	0	0	0	0	1	8501	933	33	3		3	KRT9	17	39724628	Silent	SNP	G	TCGA-26-5132-01A-01D-1486-08	12436937	39724628	41470582	50	12424											
C19orf40	91442	broad.mit.edu	37	chr19	33464993	33464993	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcttaaaggaattgtagtcGttgaaaaaacccggatgagt	10	5	1	2			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr19:33464993G>A	uc002nud.3	+	4	389	c.271G>A	c.(271-273)GTT>ATT	p.V91I	CCDC123_uc002nty.2_5'Flank|CCDC123_uc010edg.2_5'Flank|CCDC123_uc002ntz.1_5'Flank|CCDC123_uc002nua.2_5'Flank|CCDC123_uc002nuc.1_5'Flank	NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	91					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					AATTGTAGTCGTTGAAAAAAC	0.418								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks					A	33464993	A	A	33464993	3	1	174	1	0	0	0	0	1	0	0	0	1923	1145	40	1	281	1	C19orf40	19	33464993	Missense_Mutation	SNP	G	TCGA-26-5132-01A-01D-1486-08		33464993	25663990	51	12425											
DMRTC2	63946	broad.mit.edu	37	chr19	42352997	42352997	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgccaccaccagtggtgtgCcgcctgctgtaccaagaacc	10	15	0	1			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr19:42352997C>T	uc002ors.2	+	5	665	c.582C>T	c.(580-582)TGC>TGT	p.C194C	DMRTC2_uc002orr.1_Silent_p.C71C|DMRTC2_uc010xwe.1_Silent_p.C194C	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	194	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						CAGTGGTGTGCCGCCTGCTGT	0.498													T	42352997	T	T	42352997	2	4	174	1	0	0	0	0	0	0	0	1	4591	747	26	3		3	DMRTC2	19	42352997	Silent	SNP	C	TCGA-26-5132-01A-01D-1486-08	8888004	42352997	16775986	52	12426											
CD93	22918	broad.mit.edu	37	chr20	23065459	23065459	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatttggggccagcacccaGcctggcaggcagccacagtg	13	15	0	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr20:23065459G>A	uc002wsv.2	-	1	1519	c.1371C>T	c.(1369-1371)GGC>GGT	p.G457G		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	457	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCAGCACCCAGCCTGGCAGGC	0.632													A	23065459	A	A	23065459	2	1	174	1	0	0	0	0	0	0	0	1	3047	958	34	3		3	CD93	20	23065459	Silent	SNP	G	TCGA-26-5132-01A-01D-1486-08		23065459	39960061	53	12427											
TOP1	7150	broad.mit.edu	37	chr20	39704846	39704848	+	In_Frame_Del	DEL	AGG	-	-													tgaaaagaaacacaaagagaAggagaagaccaaacacaaag							TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chr20:39704846_39704848delAGG	uc002xjl.2	+	4	437_439	c.191_193delAGG	c.(190-195)AAGGAG>AAG	p.E65del	TOP1_uc010gge.1_RNA	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	65	Lys-rich.				DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	cacaaagagaaggagaagaccaa	0.207			T	NUP98	AML*								-	39704848	-	-	39704846	7	5	174	1	0	1	0	1	0	0	0	0	16360	72	3	0	205	0	TOP1	20	39704846	In_Frame_Del	DEL	AGG	TCGA-26-5132-01A-01D-1486-08	16639387	39704846	23320674	54	12428											
DCAF8L1	139425	broad.mit.edu	37	chrX	27998785	27998785	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttctgccgcacccagtcccAcactatcacccttaagtcat	4	18	3	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chrX:27998785A>G	uc004dbx.1	-	1	782	c.667T>C	c.(667-669)TGG>CGG	p.W223R		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	223	WD 1.									ovary(3)|skin(1)	4						ACCCAGTCCCACACTATCACC	0.498													G	27998785	G	G	27998785	3	3	174	1	0	0	0	0	1	0	0	0	4277	159	6	4	1139	4	DCAF8L1	23	27998785	Missense_Mutation	SNP	A	TCGA-26-5132-01A-01D-1486-08		27998785	127271775	55	12429											
MED12	9968	broad.mit.edu	37	chrX	70341430	70341430	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agtactctggggaatttgttCagtctgcatacctgtcccgc	10	11	3	0			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chrX:70341430C>T	uc004dyy.2	+	7	1064	c.865C>T	c.(865-867)CAG>TAG	p.Q289*	MED12_uc011mpq.1_Nonsense_Mutation_p.Q289*|MED12_uc004dyz.2_Nonsense_Mutation_p.Q289*|MED12_uc004dza.2_Nonsense_Mutation_p.Q136*	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	289					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GGAATTTGTTCAGTCTGCATA	0.502													T	70341430	T	T	70341430	4	4	174	1	0	0	0	0	0	1	0	0	9428	827	29	3	891	3	MED12	23	70341430	Nonsense_Mutation	SNP	C	TCGA-26-5132-01A-01D-1486-08	42342645	70341430	84929130	56	12430											
MAGEA6	4105	broad.mit.edu	37	chrX	151870122	151870122	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgatcctgcatgctatgagtTcctgtggggtccaagggccc	13	11	0	2			TCGA-26-5132-01A-01D-1486-08	TCGA-26-5132-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d1132127-1250-43af-9c16-425798a3d1a7	d3b73b4c-8cad-4fa2-b329-27b3f62f0748	g.chrX:151870122T>A	uc004ffq.1	+	3	1006	c.812T>A	c.(811-813)TTC>TAC	p.F271Y	MAGEA6_uc004ffr.1_Missense_Mutation_p.F271Y|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	271	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					TGCTATGAGTTCCTGTGGGGT	0.532													A	151870122	A	A	151870122	3	1	174	1	0	0	0	0	1	0	0	0	9170	1783	62	5	814	5	MAGEA6	23	151870122	Missense_Mutation	SNP	T	TCGA-26-5132-01A-01D-1486-08	81528692	151870122	3400438	57	12431											
MUTYH	4595	broad.mit.edu	37	chr1	45797465	45797465	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaagttgaccactcccagggTctggtcccagggctccgagg	14	13	1	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr1:45797465T>A	uc001cnm.2	-	12	1261	c.1045A>T	c.(1045-1047)ACC>TCC	p.T349S	MUTYH_uc009vxn.2_Missense_Mutation_p.T174S|MUTYH_uc001cnf.2_Missense_Mutation_p.T324S|MUTYH_uc009vxo.2_Missense_Mutation_p.T324S|MUTYH_uc001cng.2_Missense_Mutation_p.T335S|MUTYH_uc001cnj.2_Missense_Mutation_p.T232S|MUTYH_uc001cni.2_Missense_Mutation_p.T324S|MUTYH_uc001cnh.2_Missense_Mutation_p.T325S|MUTYH_uc001cno.2_Missense_Mutation_p.T232S|MUTYH_uc001cnk.2_Missense_Mutation_p.T209S|MUTYH_uc010oll.1_Intron|MUTYH_uc001cnl.2_Missense_Mutation_p.T338S|MUTYH_uc009vxp.2_Missense_Mutation_p.T352S|MUTYH_uc001cnn.2_Missense_Mutation_p.T339S	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	349					depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					ACTCCCAGGGTCTGGTCCCAG	0.652			Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				A	45797465	A	A	45797465	3	1	175	1	0	0	0	0	1	0	0	0	9993	1667	58	5	615	5	MUTYH	1	45797465	Missense_Mutation	SNP	T	TCGA-26-5133-01A-01D-1486-08		45797465	203453156	1	12432											
CTSK	1513	broad.mit.edu	37	chr1	150771721	150771721	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgcatggttcagattatcGctattgcagctttcatcata	7	9	3	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr1:150771721G>A	uc001evp.1	-	7	937	c.813C>T	c.(811-813)AGC>AGT	p.S271S	CTSK_uc001evq.1_Silent_p.S182S	NM_000396	NP_000387	P43235	CATK_HUMAN	cathepsin K preproprotein	271					proteolysis	lysosome	cysteine-type endopeptidase activity|protein binding			skin(1)	1	all_cancers(9;2.32e-51)|all_epithelial(9;3.89e-42)|all_lung(15;4.59e-35)|Lung NSC(24;1.7e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Colorectal(459;0.171)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCAGATTATCGCTATTGCAGC	0.433													A	150771721	A	A	150771721	2	1	175	1	0	0	0	0	0	0	0	1	4037	1078	38	1		1	CTSK	1	150771721	Silent	SNP	G	TCGA-26-5133-01A-01D-1486-08	104974256	150771721	98478900	2	12433											
FCRL1	115350	broad.mit.edu	37	chr1	157772382	157772382	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagcaactgagcagatgaggAccagcctgtctccctccatc	9	14	1	3			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr1:157772382A>C	uc001frg.2	-	4	505	c.392T>G	c.(391-393)GTC>GGC	p.V131G	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Missense_Mutation_p.V131G|FCRL1_uc001fri.2_Missense_Mutation_p.V131G|FCRL1_uc001frj.2_Intron	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	131	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GCAGATGAGGACCAGCCTGTC	0.542													C	157772382	C	C	157772382	3	2	175	1	0	0	0	0	1	0	0	0	5794	275	10	5	995	5	FCRL1	1	157772382	Missense_Mutation	SNP	A	TCGA-26-5133-01A-01D-1486-08	7000661	157772382	91478239	3	12434											
HMCN1	83872	broad.mit.edu	37	chr1	186097315	186097315	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tccccacttttactgaacttCctggagacgtgtcattaaat	6	11	1	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr1:186097315C>A	uc001grq.1	+	83	13025	c.12796C>A	c.(12796-12798)CCT>ACT	p.P4266T	HMCN1_uc001grs.1_5'UTR	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4266	Ig-like C2-type 42.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TACTGAACTTCCTGGAGACGT	0.418													A	186097315	A	A	186097315	3	1	175	1	0	0	0	0	1	0	0	0	7220	855	30	5	13126	5	HMCN1	1	186097315	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	28324933	186097315	63153306	4	12435											
CACNA1S	779	broad.mit.edu	37	chr1	201021762	201021762	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgggtcccatccaccaaggcGatcttcccaaacatctgcaa	7	15	2	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr1:201021762G>A	uc001gvv.2	-	32	4103	c.3876C>T	c.(3874-3876)ATC>ATT	p.I1292I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1292	Extracellular (Potential).|IV.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCACCAAGGCGATCTTCCCAA	0.557													A	201021762	A	A	201021762	2	1	175	1	0	0	0	0	0	0	0	1	2547	1048	37	2		2	CACNA1S	1	201021762	Silent	SNP	G	TCGA-26-5133-01A-01D-1486-08	14924447	201021762	48228859	5	12436											
C1orf69	200205	broad.mit.edu	37	chr1	228362831	228362831	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	caatccctgcaggcgttcctGagggggtccgagacttgcct	13	13	0	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr1:228362831G>A	uc001hsl.3	+	3	777	c.688G>A	c.(688-690)GAG>AAG	p.E230K	C1orf69_uc010pvw.1_Missense_Mutation_p.E37K	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	230					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				AGGCGTTCCTGAGGGGGTCCG	0.627													A	228362831	A	A	228362831	3	1	175	1	0	0	0	0	1	0	0	0	2057	1291	45	3	698	3	C1orf69	1	228362831	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	27341069	228362831	20887790	6	12437											
TMEM18	129787	broad.mit.edu	37	chr2	669581	669581	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tccaagcagctgctgcccctCagtcttctttccttctcctt	5	17	4	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr2:669581C>T	uc002qwl.2	-	5	516	c.422G>A	c.(421-423)TGA>TAA	p.*141*	TMEM18_uc002qwk.2_RNA	NM_152834	NP_690047	Q96B42	TMM18_HUMAN	transmembrane protein 18	141					cell migration	integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)		TGCTGCCCCTCAGTCttcttt	0.448													T	669581	T	T	669581	2	4	175	1	0	0	0	0	0	0	0	1	16095	837	29	3		3	TMEM18	2	669581	Silent	SNP	C	TCGA-26-5133-01A-01D-1486-08		669581	242529792	7	12438											
GREB1	9687	broad.mit.edu	37	chr2	11750922	11750922	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagatgaagaactacacgtcGgtggagacgctggagatcac	13	9	1	5			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr2:11750922G>A	uc002rbk.1	+	18	3075	c.2775G>A	c.(2773-2775)TCG>TCA	p.S925S	GREB1_uc002rbo.1_Silent_p.S559S|GREB1_uc002rbp.1_5'Flank	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	925						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACTACACGTCGGTGGAGACGC	0.657													A	11750922	A	A	11750922	2	1	175	1	0	0	0	0	0	0	0	1	6760	1103	39	2		2	GREB1	2	11750922	Silent	SNP	G	TCGA-26-5133-01A-01D-1486-08	11081341	11750922	231448451	8	12439											
APOB	338	broad.mit.edu	37	chr2	21225763	21225763	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atatggaattcttgagtaacTcgtaccaagccatcaaacac	6	10	2	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr2:21225763T>C	uc002red.2	-	29	12659	c.12531A>G	c.(12529-12531)CGA>CGG	p.R4177R		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4177					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTGAGTAACTCGTACCAAGC	0.463													C	21225763	C	C	21225763	2	2	175	1	0	0	0	0	0	0	0	1	785	1538	54	4		4	APOB	2	21225763	Silent	SNP	T	TCGA-26-5133-01A-01D-1486-08	9474841	21225763	221973610	9	12440											
FAM128A	653784	broad.mit.edu	37	chr2	132241729	132241729	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catcctctggctggatccctCgtggttgctgcgttccgcca	11	15	1	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr2:132241729C>T	uc002tsw.3	-	3	497	c.382G>A	c.(382-384)GAG>AAG	p.E128K	FAM128A_uc002tsv.3_RNA	NM_001085365	NP_001078834	Q6P582	MZT2A_HUMAN	hypothetical protein LOC653784	128						centrosome|gamma-tubulin ring complex|spindle					0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CTGGATCCCTCGTGGTTGCTG	0.642													T	132241729	T	T	132241729	3	4	175	1	0	0	0	0	1	0	0	0	5434	893	31	2	98	2	FAM128A	2	132241729	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	111015966	132241729	110957644	10	12441											
FMNL2	114793	broad.mit.edu	37	chr2	153399316	153399316	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agctcaaaggctatctggatCcagctgtaaccaggaaggta	11	9	2	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr2:153399316C>T	uc002tye.2	+	3	632	c.265C>T	c.(265-267)CCA>TCA	p.P89S		NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	89	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						CTATCTGGATCCAGCTGTAAC	0.433													T	153399316	T	T	153399316	3	4	175	1	0	0	0	0	1	0	0	0	5952	855	30	3	275	3	FMNL2	2	153399316	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	21157587	153399316	89800057	11	12442											
ACVR1C	130399	broad.mit.edu	37	chr2	158485147	158485147	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggagcgctgagcagagcgCccgggtcatcgccaccaggc	16	15	1	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr2:158485147C>T	uc002tzk.3	-	1	253	c.10G>A	c.(10-12)GCG>ACG	p.A4T	ACVR1C_uc002tzl.3_Missense_Mutation_p.A4T|ACVR1C_uc010fof.2_Missense_Mutation_p.A4T	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	4					apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						GAGCAGAGCGCCCGGGTCATC	0.751													T	158485147	T	T	158485147	3	4	175	1	0	0	0	0	1	0	0	0	222	739	26	3	1507	3	ACVR1C	2	158485147	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	5085831	158485147	84714226	12	12443											
CPS1	1373	broad.mit.edu	37	chr2	211476895	211476895	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccagaaagctttacggatgTgccacccatctatagaaggt	9	10	1	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr2:211476895T>C	uc002vee.3	+	20	2578	c.2446T>C	c.(2446-2448)TGC>CGC	p.C816R	CPS1_uc010fur.2_Missense_Mutation_p.C822R|CPS1_uc010fus.2_Missense_Mutation_p.C365R	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	816					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTTACGGATGTGCCACCCATC	0.413													C	211476895	C	C	211476895	3	2	175	1	0	0	0	0	1	0	0	0	3823	1696	59	4	2546	4	CPS1	2	211476895	Missense_Mutation	SNP	T	TCGA-26-5133-01A-01D-1486-08	52991748	211476895	31722478	13	12444											
CYP27A1	1593	broad.mit.edu	37	chr2	219677652	219677652	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgttgctttcacagggaagAagctgattgatgagaagctc	12	7	1	4	rs72551319		TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr2:219677652A>C	uc002viz.3	+	5	1284	c.850A>C	c.(850-852)AAG>CAG	p.K284Q		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	284					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	CACAGGGAAGAAGCTGATTGA	0.517													C	219677652	C	C	219677652	3	2	175	1	0	0	0	0	1	0	0	0	4158	247	9	5	868	5	CYP27A1	2	219677652	Missense_Mutation	SNP	A	TCGA-26-5133-01A-01D-1486-08	8200757	219677652	23521721	14	12445											
C2orf54	79919	broad.mit.edu	37	chr2	241831024	241831024	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccttctcaagctgccctcaGggaatccgggcatctgctgc	10	15	3	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr2:241831024G>A	uc002wae.3	-	2	830	c.671C>T	c.(670-672)CCT>CTT	p.P224L	C2orf54_uc002wac.2_Missense_Mutation_p.P56L|C2orf54_uc002wad.2_Missense_Mutation_p.P75L	NM_001085437	NP_001078906	Q08AI8	CB054_HUMAN	hypothetical protein LOC79919 isoform 1	224											0		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		GCTGCCCTCAGGGAATCCGGG	0.647													A	241831024	A	A	241831024	3	1	175	1	0	0	0	0	1	0	0	0	2175	1000	35	3	688	3	C2orf54	2	241831024	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	22153372	241831024	1368349	15	12446											
CX3CR1	1524	broad.mit.edu	37	chr3	39307958	39307958	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acaggcctcagccaaatcatCgtactcaaagttttctgtca	6	12	5	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr3:39307958C>T	uc003cjl.2	-	2	135	c.43G>A	c.(43-45)GAT>AAT	p.D15N		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	15	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		GCCAAATCATCGTACTCAAAG	0.448													T	39307958	T	T	39307958	3	4	175	1	0	0	0	0	1	0	0	0	4075	884	31	2	1028	2	CX3CR1	3	39307958	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08		39307958	158714472	16	12447											
BAP1	8314	broad.mit.edu	37	chr3	52442518	52442518	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaagaacatgttattcacaAtatcatcatcaatcacggac	4	10	5	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr3:52442518A>G	uc003ddx.2	-	4	342	c.227T>C	c.(226-228)ATT>ACT	p.I76T	PHF7_uc003ddy.2_5'Flank|PHF7_uc003ddz.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	76					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		GTTATTCACAATATCATCATC	0.478			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								G	52442518	G	G	52442518	3	3	175	1	0	0	0	0	1	0	0	0	1311	101	4	4	2018	4	BAP1	3	52442518	Missense_Mutation	SNP	A	TCGA-26-5133-01A-01D-1486-08	13134560	52442518	145579912	17	12448											
PRKCD	5580	broad.mit.edu	37	chr3	53220653	53220653	+	Frame_Shift_Del	DEL	G	-	-													ttgtgatggagttcctcaacGggggggacctgatgtaccac							TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr3:53220653delG	uc003dgl.2	+	14	1647	c.1294delG	c.(1294-1296)GGGfs	p.G432fs	PRKCD_uc003dgm.2_Frame_Shift_Del_p.G432fs	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	432	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GTTCCTCAACGGGGGGGACCT	0.602													-	53220653	-	-	53220653	7	5	175	1	0	1	0	1	0	0	0	0	12509	1116	39	0	1340	0	PRKCD	3	53220653	Frame_Shift_Del	DEL	G	TCGA-26-5133-01A-01D-1486-08	778135	53220653	144801777	18	12449											
ATXN7	6314	broad.mit.edu	37	chr3	63898472	63898472	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggaggacggcgggcccggCgccgcctccacctcggccgc	16	20	0	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr3:63898472C>T	uc003dlw.3	+	3	751	c.198C>T	c.(196-198)GGC>GGT	p.G66G	ATXN7_uc003dlv.2_Silent_p.G66G|ATXN7_uc010hnv.2_Silent_p.G66G|ATXN7_uc010hnu.1_RNA	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	66					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		gcgggcccggcgccgccTCCA	0.308													T	63898472	T	T	63898472	2	4	175	1	0	0	0	0	0	0	0	1	1215	755	27	1		1	ATXN7	3	63898472	Silent	SNP	C	TCGA-26-5133-01A-01D-1486-08	10677819	63898472	134123958	19	12450											
SR140	23350	broad.mit.edu	37	chr3	142731118	142731118	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caagtcggacacgacctaagAgcccaagaaaacataattat	7	10	0	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr3:142731118A>G	uc003evh.1	+	3	244	c.145A>G	c.(145-147)AGC>GGC	p.S49G	SR140_uc003evi.1_5'UTR|SR140_uc011bnj.1_Missense_Mutation_p.S49G|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.S49G	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	49					RNA processing	nucleus	nucleotide binding|RNA binding				0						ACGACCTAAGAGCCCAAGAAA	0.388													G	142731118	G	G	142731118	3	3	175	1	0	0	0	0	1	0	0	0	15130	304	11	4	155	4	SR140	3	142731118	Missense_Mutation	SNP	A	TCGA-26-5133-01A-01D-1486-08	78832646	142731118	55291312	20	12451											
ZBBX	79740	broad.mit.edu	37	chr3	167034878	167034878	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ataaaagagctgtgtgttgtActttggtctcctcacctagg	10	8	2	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr3:167034878A>T	uc003fep.2	-	14	1432	c.1109T>A	c.(1108-1110)GTA>GAA	p.V370E	ZBBX_uc011bpc.1_Missense_Mutation_p.V370E|ZBBX_uc003feq.2_Missense_Mutation_p.V341E	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	370						intracellular	zinc ion binding			ovary(2)	2						TGTGTGTTGTACTTTGGTCTC	0.328													T	167034878	T	T	167034878	3	4	175	1	0	0	0	0	1	0	0	0	17513	391	14	5	1325	5	ZBBX	3	167034878	Missense_Mutation	SNP	A	TCGA-26-5133-01A-01D-1486-08	24303760	167034878	30987552	21	12452											
TMEM44	93109	broad.mit.edu	37	chr3	194325157	194325157	+	Frame_Shift_Del	DEL	G	-	-													tgcccgtcacctggcagcctGgtggcactgcagcctgcctg							TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr3:194325157delG	uc010hzn.2	-	10	1345	c.1176delC	c.(1174-1176)ACCfs	p.T392fs	TMEM44_uc010hzm.2_Frame_Shift_Del_p.P76fs|TMEM44_uc003fuc.2_Frame_Shift_Del_p.T77fs|TMEM44_uc003fue.2_Frame_Shift_Del_p.T345fs|TMEM44_uc003fud.2_Frame_Shift_Del_p.T345fs|TMEM44_uc003fuf.2_Frame_Shift_Del_p.P344fs|TMEM44_uc011bsv.1_Frame_Shift_Del_p.T345fs|TMEM44_uc003fuh.1_RNA	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	392	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		CTGGCAGCCTGGTGGCACTGC	0.597													-	194325157	-	-	194325157	7	5	175	1	0	1	0	1	0	0	0	0	16165	1348	47	0	293	0	TMEM44	3	194325157	Frame_Shift_Del	DEL	G	TCGA-26-5133-01A-01D-1486-08	27290279	194325157	3697273	22	12453											
KIAA0232	9778	broad.mit.edu	37	chr4	6865692	6865692	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcagacatcactggattccCaggaggaatcaactgggatt	10	10	3	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr4:6865692C>T	uc003gjr.3	+	7	4046	c.3583C>T	c.(3583-3585)CAG>TAG	p.Q1195*	KIAA0232_uc003gjq.3_Nonsense_Mutation_p.Q1195*	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	1195							ATP binding			ovary(2)	2						ACTGGATTCCCAGGAGGAATC	0.408													T	6865692	T	T	6865692	4	4	175	1	0	0	0	0	0	1	0	0	8163	595	21	3	3601	3	KIAA0232	4	6865692	Nonsense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08		6865692	184288584	23	12454											
NAAA	27163	broad.mit.edu	37	chr4	76842123	76842123	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cgctccattcaaaggatctaGaggccaaatgtctgctgggc	11	11	3	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr4:76842123G>C	uc003hjb.2	-	6	884	c.820C>G	c.(820-822)CTA>GTA	p.L274V	NAAA_uc003hja.2_Missense_Mutation_p.L274V|NAAA_uc003hjc.3_Missense_Mutation_p.L274V|NAAA_uc003hjd.3_RNA|NAAA_uc011cbq.1_Missense_Mutation_p.L173V	NM_014435	NP_055250	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase isoform 1	274					lipid metabolic process	lysosome	hydrolase activity			skin(1)	1						AAAGGATCTAGAGGCCAAATG	0.433													C	76842123	C	C	76842123	3	2	175	1	0	0	0	0	1	0	0	0	10127	933	33	5	286	5	NAAA	4	76842123	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	69976431	76842123	114312153	24	12455											
PET112L	5188	broad.mit.edu	37	chr4	152592379	152592379	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcatgactggatctgctcGgctttgagtcgctttccgga	11	10	2	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr4:152592379G>A	uc003iml.2	-	13	1633	c.1621C>T	c.(1621-1623)CGA>TGA	p.R541*	PET112L_uc003imk.2_RNA	NM_004564	NP_004555	O75879	GATB_HUMAN	PET112-like precursor	541						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding				0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)			L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGATCTGCTCGGCTTTGAGTC	0.453													A	152592379	A	A	152592379	4	1	175	1	0	0	0	0	0	1	0	0	11734	1124	39	2	56	2	PET112L	4	152592379	Nonsense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	75750256	152592379	38561897	25	12456											
ETFDH	2110	broad.mit.edu	37	chr4	159603468	159603468	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcacatgaaaaggacatccgTgtgtgtctagtggagaaagc	13	7	1	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr4:159603468T>C	uc003iqb.2	+	3	629	c.297T>C	c.(295-297)CGT>CGC	p.R99R	ETFDH_uc011cjg.1_Silent_p.R52R|ETFDH_uc010iqr.2_Intron|ETFDH_uc011cjh.1_Silent_p.R38R|ETFDH_uc010iqs.2_Silent_p.R38R	NM_004453	NP_004444	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	99					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			large_intestine(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		AGGACATCCGTGTGTGTCTAG	0.502													C	159603468	C	C	159603468	2	2	175	1	0	0	0	0	0	0	0	1	5271	1683	59	4		4	ETFDH	4	159603468	Silent	SNP	T	TCGA-26-5133-01A-01D-1486-08	7011089	159603468	31550808	26	12457											
PCDHGB1	56104	broad.mit.edu	37	chr5	140729895	140729896	+	Frame_Shift_Del	DEL	TC	-	-													tcccttcctgctgtctttgtTctgcggggccatctcccagc							TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr5:140729895_140729896delTC	uc003ljo.1	+	1	68_69	c.68_69delTC	c.(67-69)TTCfs	p.F23fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Frame_Shift_Del_p.F23fs	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	23					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTCTTTGTTCTGCGGGGCCA	0.55											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	140729896	-	-	140729895	7	5	175	1	0	1	0	1	0	0	0	0	11562	1783	62	0	70	0	PCDHGB1	5	140729895	Frame_Shift_Del	DEL	TC	TCGA-26-5133-01A-01D-1486-08		140729895	40185365	27	12458											
C6orf10	10665	broad.mit.edu	37	chr6	32260945	32260945	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tctctgcatctctctcctttTctttatcattatttccttta	1	12	5	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr6:32260945T>A	uc011dpy.1	-	12	1678	c.1505A>T	c.(1504-1506)GAA>GTA	p.E502V	C6orf10_uc011dpx.1_Intron	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	502	Lys-rich.					integral to membrane				skin(1)	1						tctctccttttctttatcatt	0.174													A	32260945	A	A	32260945	3	1	175	1	0	0	0	0	1	0	0	0	2317	1783	62	5	190	5	C6orf10	6	32260945	Missense_Mutation	SNP	T	TCGA-26-5133-01A-01D-1486-08		32260945	138854122	28	12459											
HLA-DMB	3109	broad.mit.edu	37	chr6	32903319	32903319	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgagtcactcactagagtGgccagctctccgccagctga	11	14	3	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr6:32903319G>A	uc003ocl.1	-	4	966	c.733C>T	c.(733-735)CAC>TAC	p.H245Y	HLA-DMB_uc003ocj.1_3'UTR|HLA-DMB_uc003ock.1_RNA|HLA-DMB_uc010jud.1_Missense_Mutation_p.H114Y|HLA-DMB_uc010jue.1_Intron|HLA-DMB_uc010juf.1_Intron	NM_002118	NP_002109	P28068	DMB_HUMAN	major histocompatibility complex, class II, DM	245	Cytoplasmic (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						TCACTAGAGTGGCCAGCTCTC	0.537													A	32903319	A	A	32903319	3	1	175	1	0	0	0	0	1	0	0	0	7199	1348	47	3	70	3	HLA-DMB	6	32903319	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	642374	32903319	138211748	29	12460											
GRM4	2914	broad.mit.edu	37	chr6	34004117	34004117	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accacggccaggaagaggggCagcacggcccagggcgagcc	17	14	0	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr6:34004117C>T	uc003oir.3	-	8	1940	c.1770G>A	c.(1768-1770)CTG>CTA	p.L590L	GRM4_uc011dsn.1_Silent_p.L543L|GRM4_uc010jvh.2_Silent_p.L590L|GRM4_uc010jvi.2_Silent_p.L282L|GRM4_uc003oio.2_Silent_p.L282L|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Silent_p.L450L|GRM4_uc003oiq.2_Silent_p.L457L|GRM4_uc011dsm.1_Silent_p.L421L	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	590	Helical; Name=1; (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	GGAAGAGGGGCAGCACGGCCC	0.647													T	34004117	T	T	34004117	2	4	175	1	0	0	0	0	0	0	0	1	6799	697	25	3		3	GRM4	6	34004117	Silent	SNP	C	TCGA-26-5133-01A-01D-1486-08	1100798	34004117	137110950	30	12461											
MCM3	4172	broad.mit.edu	37	chr6	52149470	52149470	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tccagcaccacggtacccgcCatgcccgctgccaaagaact	8	18	0	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr6:52149470C>G	uc003pan.1	-	1	113	c.3G>C	c.(1-3)ATG>ATC	p.M1I	MCM3_uc011dwu.1_5'UTR	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	1					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					CGGTACCCGCCATGCCCGCTG	0.642													G	52149470	G	G	52149470	3	3	175	1	0	0	0	0	1	0	0	0	9387	594	21	5	2491	5	MCM3	6	52149470	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	18145353	52149470	118965597	31	12462											
IKZF1	10320	broad.mit.edu	37	chr7	50450397	50450397	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcactggccacctgaggaCgcactccggtaggtcccctg	11	17	1	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr7:50450397C>T	uc003tow.3	+	6	749	c.581C>T	c.(580-582)ACG>ATG	p.T194M	IKZF1_uc003tox.3_Missense_Mutation_p.T194M|IKZF1_uc003toy.3_Missense_Mutation_p.T194M|IKZF1_uc011kck.1_Missense_Mutation_p.T107M|IKZF1_uc003toz.3_Missense_Mutation_p.T164M|IKZF1_uc010kyx.2_Intron	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	194	C2H2-type 3.|Required for both high-affinity DNA binding and pericentromeric heterochromatin localization (By similarity).				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(74)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CACCTGAGGACGCACTCCGGT	0.657			D		ALL								T	50450397	T	T	50450397	3	4	175	1	0	0	0	0	1	0	0	0	7614	536	19	1	595	1	IKZF1	7	50450397	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08		50450397	108688266	32	12463											
TAF6	6878	broad.mit.edu	37	chr7	99711354	99711354	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cccccaccagaggcgaagcgGaaaggaatgaactcctgggc	13	13	0	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr7:99711354G>A	uc003uti.2	-	4	363	c.282C>T	c.(280-282)TTC>TTT	p.F94F	TAF6_uc003utg.2_Silent_p.F35F|TAF6_uc003uth.2_Silent_p.F151F|TAF6_uc003utk.2_Silent_p.F94F|TAF6_uc011kji.1_Silent_p.F131F|TAF6_uc003utj.2_Silent_p.F84F|TAF6_uc003utl.2_Silent_p.F94F|TAF6_uc003utm.2_Silent_p.F94F|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	94					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGGCGAAGCGGAAAGGAATGA	0.602													A	99711354	A	A	99711354	2	1	175	1	0	0	0	0	0	0	0	1	15527	1165	41	3		3	TAF6	7	99711354	Silent	SNP	G	TCGA-26-5133-01A-01D-1486-08	49260957	99711354	59427309	33	12464											
PIK3CG	5294	broad.mit.edu	37	chr7	106509904	106509904	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacaatgcagctcctggactGcaacttctcagatgaaaatg	8	10	1	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr7:106509904G>A	uc003vdv.3	+	2	1983	c.1898G>A	c.(1897-1899)TGC>TAC	p.C633Y	PIK3CG_uc003vdu.2_Missense_Mutation_p.C633Y|PIK3CG_uc003vdw.2_Missense_Mutation_p.C633Y	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	633					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CTCCTGGACTGCAACTTCTCA	0.333													A	106509904	A	A	106509904	3	1	175	1	0	0	0	0	1	0	0	0	11916	1319	46	3	1900	3	PIK3CG	7	106509904	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	6798550	106509904	52628759	34	12465											
ADAMDEC1	27299	broad.mit.edu	37	chr8	24251623	24251623	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cactgaaacattgtactcacCcagaggagaggaaattacca	8	10	1	3			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr8:24251623C>A	uc003xdz.2	+	4	546	c.326C>A	c.(325-327)CCC>CAC	p.P109H	ADAMDEC1_uc010lub.2_Missense_Mutation_p.P30H|ADAMDEC1_uc011lab.1_Missense_Mutation_p.P30H	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	109					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TTGTACTCACCCAGAGGAGAG	0.463													A	24251623	A	A	24251623	3	1	175	1	0	0	0	0	1	0	0	0	254	623	22	5	340	5	ADAMDEC1	8	24251623	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08		24251623	122112399	35	12466											
SNTB1	6641	broad.mit.edu	37	chr8	121644863	121644863	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttaggatcaccgtgtgctTagcatctggagagtggattt	12	8	2	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr8:121644863T>C	uc010mdg.2	-	3	1043	c.817A>G	c.(817-819)AAG>GAG	p.K273E	SNTB1_uc003ype.2_Missense_Mutation_p.K273E	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	273	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			ACCGTGTGCTTAGCATCTGGA	0.527													C	121644863	C	C	121644863	3	2	175	1	0	0	0	0	1	0	0	0	14872	1763	61	4	819	4	SNTB1	8	121644863	Missense_Mutation	SNP	T	TCGA-26-5133-01A-01D-1486-08	97393240	121644863	24719159	36	12467											
SH2D3C	10044	broad.mit.edu	37	chr9	130507361	130507361	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagaaggggctgcaggggCggcatggacacgggttactg	20	8	0	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr9:130507361C>T	uc004bsc.2	-	7	1424	c.1282G>A	c.(1282-1284)GCC>ACC	p.A428T	SH2D3C_uc010mxo.2_Missense_Mutation_p.A268T|SH2D3C_uc004bry.2_Missense_Mutation_p.A270T|SH2D3C_uc004brz.3_Missense_Mutation_p.A74T|SH2D3C_uc011mak.1_Missense_Mutation_p.A74T|SH2D3C_uc004bsa.2_Missense_Mutation_p.A271T|SH2D3C_uc004bsb.2_Missense_Mutation_p.A360T	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	428					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						GCTGCAGGGGCGGCATGGACA	0.627													T	130507361	T	T	130507361	3	4	175	1	0	0	0	0	1	0	0	0	14234	768	27	1	1324	1	SH2D3C	9	130507361	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08		130507361	10706070	37	12468											
GFI1B	8328	broad.mit.edu	37	chr9	135863634	135863634	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atggggactctccactgtccGactcacccccattctacaag	7	16	3	0	rs145562579		TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr9:135863634G>A	uc004ccg.2	+	4	440	c.289G>A	c.(289-291)GAC>AAC	p.D97N	GFI1B_uc010mzy.2_Missense_Mutation_p.D97N	NM_004188	NP_004179	Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription	97	Interaction with ARIH2.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		TCCACTGTCCGACTCACCCCC	0.587													A	135863634	A	A	135863634	3	1	175	1	0	0	0	0	1	0	0	0	6340	1058	37	2	299	2	GFI1B	9	135863634	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	5356273	135863634	5349797	38	12469											
PCDH15	65217	broad.mit.edu	37	chr10	55591167	55591167	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaggccccttctgtgtatccTagactttctcctctcttttt	5	13	3	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr10:55591167T>C	uc001jju.1	-	30	4505	c.4110A>G	c.(4108-4110)CTA>CTG	p.L1370L	PCDH15_uc010qhq.1_Silent_p.L1375L|PCDH15_uc010qhr.1_Silent_p.L1370L|PCDH15_uc010qhs.1_Silent_p.L1382L|PCDH15_uc010qht.1_Silent_p.L1377L|PCDH15_uc010qhu.1_Silent_p.L1370L|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Silent_p.L1370L|PCDH15_uc010qhw.1_Silent_p.L1333L|PCDH15_uc010qhx.1_Silent_p.L1299L|PCDH15_uc010qhy.1_Silent_p.L1375L|PCDH15_uc010qhz.1_Silent_p.L1370L|PCDH15_uc010qia.1_Silent_p.L1348L|PCDH15_uc010qib.1_Silent_p.L1348L	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1370	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGTGTATCCTAGACTTTCTC	0.483										HNSCC(58;0.16)			C	55591167	C	C	55591167	2	2	175	1	0	0	0	0	0	0	0	1	11511	1509	53	4		4	PCDH15	10	55591167	Silent	SNP	T	TCGA-26-5133-01A-01D-1486-08		55591167	79943580	39	12470											
PLA2G16	11145	broad.mit.edu	37	chr11	63381479	63381479	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccccgcacttacaatgggcGcacgcatcttccctcgcggt	10	17	1	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr11:63381479G>A	uc001nxh.2	-	1	431	c.8C>T	c.(7-9)GCG>GTG	p.A3V	PLA2G16_uc001nxi.2_Missense_Mutation_p.R32C|PLA2G16_uc009you.1_Missense_Mutation_p.A3V	NM_007069	NP_009000	P53816	PAG16_HUMAN	HRAS-like suppressor 3	3					lipid catabolic process	integral to membrane|perinuclear region of cytoplasm	hydrolase activity|protein binding			ovary(1)	1						TACAATGGGCGCACGCATCTT	0.478													A	63381479	A	A	63381479	3	1	175	1	0	0	0	0	1	0	0	0	11993	1087	38	1	496	1	PLA2G16	11	63381479	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08		63381479	71625037	40	12471											
ANO6	196527	broad.mit.edu	37	chr12	45823037	45823037	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atgacgaaaaatatgggggtGatagctgagcggatgataga	15	3	0	5			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr12:45823037G>A	uc001roo.2	+	20	3011	c.2676G>A	c.(2674-2676)GTG>GTA	p.V892V	ANO6_uc010sld.1_Intron|ANO6_uc010sle.1_Intron|ANO6_uc010slf.1_Silent_p.V913V|ANO6_uc010slg.1_Silent_p.V874V	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	892	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						ATATGGGGGTGATAGCTGAGC	0.373													A	45823037	A	A	45823037	2	1	175	1	0	0	0	0	0	0	0	1	701	1277	45	3		3	ANO6	12	45823037	Silent	SNP	G	TCGA-26-5133-01A-01D-1486-08		45823037	88028858	41	12472											
STAT6	6778	broad.mit.edu	37	chr12	57490672	57490672	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtcactggctggctcaggCagctgtcttccaccatggtc	11	14	3	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr12:57490672C>T	uc009zpe.2	-	21	2566	c.2315G>A	c.(2314-2316)TGC>TAC	p.C772Y	STAT6_uc009zpf.2_Missense_Mutation_p.C772Y|STAT6_uc001sna.2_Missense_Mutation_p.C772Y|STAT6_uc010srb.1_Missense_Mutation_p.C662Y|STAT6_uc010src.1_Missense_Mutation_p.C662Y|STAT6_uc010srd.1_Missense_Mutation_p.C662Y|STAT6_uc009zpg.2_Missense_Mutation_p.C821Y	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	772					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						CTGGCTCAGGCAGCTGTCTTC	0.642													T	57490672	T	T	57490672	3	4	175	1	0	0	0	0	1	0	0	0	15269	710	25	3	236	3	STAT6	12	57490672	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	11667635	57490672	76361223	42	12473											
OSBPL8	114882	broad.mit.edu	37	chr12	76791554	76791554	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttgatggacgttcaatgaTttcacaggcattcagaagaa	9	6	3	4			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr12:76791554T>C	uc001sye.1	-	8	1072	c.592A>G	c.(592-594)ATC>GTC	p.I198V	OSBPL8_uc001syf.1_Missense_Mutation_p.I156V|OSBPL8_uc001syg.1_Missense_Mutation_p.I156V|OSBPL8_uc001syh.1_Missense_Mutation_p.I173V	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	198	PH.				lipid transport		lipid binding			ovary(1)	1						CGTTCAATGATTTCACAGGCA	0.408													C	76791554	C	C	76791554	3	2	175	1	0	0	0	0	1	0	0	0	11283	1493	52	4	2145	4	OSBPL8	12	76791554	Missense_Mutation	SNP	T	TCGA-26-5133-01A-01D-1486-08	19300882	76791554	57060341	43	12474											
EP400	57634	broad.mit.edu	37	chr12	132551418	132551418	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaagcctccggtggtgtccGtcccggcagctgtggtctcc	14	15	1	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr12:132551418G>A	uc001ujn.2	+	48	8688	c.8653G>A	c.(8653-8655)GTC>ATC	p.V2885I	EP400_uc001ujl.2_Missense_Mutation_p.V2884I|EP400_uc001ujm.2_Missense_Mutation_p.V2804I|EP400_uc001ujp.2_Missense_Mutation_p.V95I	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2921					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.P2885P(1)		central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGTGGTGTCCGTCCCGGCAGC	0.682													A	132551418	A	A	132551418	3	1	175	1	0	0	0	0	1	0	0	0	5149	1145	40	1	8840	1	EP400	12	132551418	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	55759864	132551418	1300477	44	12475											
LMO7	4008	broad.mit.edu	37	chr13	76287343	76287343	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aacagagaagaattttgaaaCaaaagattttcgagcctctc	7	7	1	4	rs75385907		TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr13:76287343C>A	uc010thv.1	+	3	1511	c.251C>A	c.(250-252)ACA>AAA	p.T84K	LMO7_uc001vjt.1_Missense_Mutation_p.T32K	NM_005358	NP_005349	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 1	84	CH.					cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AATTTTGAAACAAAAGATTTT	0.318													A	76287343	A	A	76287343	3	1	175	1	0	0	0	0	1	0	0	0	8855	478	17	5	261	5	LMO7	13	76287343	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08		76287343	38882535	45	12476											
OR11G2	390439	broad.mit.edu	37	chr14	20666093	20666093	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttcttgattcctatcgtcaAcatctcccaaatgtccttct	4	13	4	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr14:20666093A>G	uc010tlb.1	+	1	599	c.599A>G	c.(598-600)AAC>AGC	p.N200S		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	200	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CCTATCGTCAACATCTCCCAA	0.448													G	20666093	G	G	20666093	3	3	175	1	0	0	0	0	1	0	0	0	10925	43	2	4	601	4	OR11G2	14	20666093	Missense_Mutation	SNP	A	TCGA-26-5133-01A-01D-1486-08		20666093	86683447	46	12477											
AKAP5	9495	broad.mit.edu	37	chr14	64936331	64936331	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaagaatgctattcagttgTcaatagaacagctggttaat	8	6	3	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr14:64936331T>C	uc001xhd.3	+	2	1597	c.1219T>C	c.(1219-1221)TCA>CCA	p.S407P	ZBTB25_uc001xhc.2_Intron	NM_004857	NP_004848	P24588	AKAP5_HUMAN	A-kinase anchor protein 5	407				S -> Y (in Ref. 3).	energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding				0				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		TATTCAGTTGTCAATAGAACA	0.348													C	64936331	C	C	64936331	3	2	175	1	0	0	0	0	1	0	0	0	454	1667	58	4	1221	4	AKAP5	14	64936331	Missense_Mutation	SNP	T	TCGA-26-5133-01A-01D-1486-08	44270238	64936331	42413209	47	12478											
HEATR4	399671	broad.mit.edu	37	chr14	73989140	73989140	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgtgactccagtcgtactgCtggcgcaggaagctctgcca	12	12	1	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr14:73989140C>A	uc010tub.1	-	3	1039	c.717G>T	c.(715-717)CAG>CAT	p.Q239H	HEATR4_uc010tua.1_Missense_Mutation_p.Q192H	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		AGTCGTACTGCTGGCGCAGGA	0.582													A	73989140	A	A	73989140	3	1	175	1	0	0	0	0	1	0	0	0	7030	796	28	5	2427	5	HEATR4	14	73989140	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	9052809	73989140	33360400	48	12479											
LTBP2	4053	broad.mit.edu	37	chr14	74974771	74974771	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagtgccctcccacacacGggtctgtggtggcacactcg	11	16	1	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr14:74974771G>A	uc001xqa.2	-	25	4067	c.3680C>T	c.(3679-3681)CCG>CTG	p.P1227L		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1227	EGF-like 13; calcium-binding (Potential).|Cys-rich.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TCCCACACACGGGTCTGTGGT	0.582													A	74974771	A	A	74974771	3	1	175	1	0	0	0	0	1	0	0	0	9074	1116	39	2	1833	2	LTBP2	14	74974771	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	985631	74974771	32374769	49	12480											
ATP8B4	79895	broad.mit.edu	37	chr15	50190419	50190419	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caagcaagttctaggagatcAttcttgacatcactttctag	7	9	5	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr15:50190419A>T	uc001zxu.2	-	22	2461	c.2319T>A	c.(2317-2319)AAT>AAA	p.N773K	ATP8B4_uc010ber.2_Missense_Mutation_p.N646K|ATP8B4_uc010ufd.1_Missense_Mutation_p.N583K|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Missense_Mutation_p.N71K	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	773	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTAGGAGATCATTCTTGACAT	0.398													T	50190419	T	T	50190419	3	4	175	1	0	0	0	0	1	0	0	0	1197	214	8	5	1287	5	ATP8B4	15	50190419	Missense_Mutation	SNP	A	TCGA-26-5133-01A-01D-1486-08		50190419	52340973	50	12481											
C15orf60	283677	broad.mit.edu	37	chr15	73832877	73832877	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttgaagattgtaagacgcGtggattgtctgttgtttgga	15	3	1	3			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr15:73832877G>A	uc002avq.2	+	3	329	c.301G>A	c.(301-303)GTG>ATG	p.V101M	C15orf60_uc010bjb.2_Intron	NM_001042367	NP_001035826	Q7Z4M0	CO060_HUMAN	hypothetical protein LOC283677	101										pancreas(1)	1						TGTAAGACGCGTGGATTGTCT	0.383													A	73832877	A	A	73832877	3	1	175	1	0	0	0	0	1	0	0	0	1808	1145	40	1	311	1	C15orf60	15	73832877	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	23642458	73832877	28698515	51	12482											
KIAA1199	57214	broad.mit.edu	37	chr15	81213426	81213426	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caacaacctcatcaactgtgCcgctgcaggatctgaggtga	10	12	3	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr15:81213426C>T	uc002bfw.1	+	15	2317	c.2057C>T	c.(2056-2058)GCC>GTC	p.A686V	KIAA1199_uc010unn.1_Missense_Mutation_p.A686V	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	686										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						ATCAACTGTGCCGCTGCAGGA	0.547													T	81213426	T	T	81213426	3	4	175	1	0	0	0	0	1	0	0	0	8213	739	26	3	2111	3	KIAA1199	15	81213426	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	7380549	81213426	21317966	52	12483											
RHBDL1	9028	broad.mit.edu	37	chr16	727863	727863	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacagcccagcttcatggcGcacctggcaggcgcggtggt	14	15	1	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr16:727863G>A	uc002cis.1	+	7	1155	c.1128G>A	c.(1126-1128)GCG>GCA	p.A376A	RHBDL1_uc002cir.1_Silent_p.A311A|RHBDL1_uc010uun.1_3'UTR|STUB1_uc002cit.2_5'Flank|STUB1_uc002ciu.2_5'Flank|STUB1_uc010bqz.2_5'Flank|STUB1_uc002civ.2_5'Flank	NM_003961	NP_003952	O75783	RHBL1_HUMAN	rhomboid protease 1	376	Helical; (Potential).				proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)				GCTTCATGGCGCACCTGGCAG	0.736													A	727863	A	A	727863	2	1	175	1	0	0	0	0	0	0	0	1	13321	1074	38	1		1	RHBDL1	16	727863	Silent	SNP	G	TCGA-26-5133-01A-01D-1486-08		727863	89626890	53	12484											
KIAA0430	9665	broad.mit.edu	37	chr16	15690712	15690712	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagctgctgagatgcaggaCgagctggagtcagaggtcag	16	8	2	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr16:15690712C>T	uc002ddr.2	-	27	5260	c.5067G>A	c.(5065-5067)TCG>TCA	p.S1689S	KIAA0430_uc002ddq.2_Silent_p.S1523S|KIAA0430_uc010uzv.1_Silent_p.S1685S|KIAA0430_uc010uzw.1_Silent_p.S1688S	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1688	Poly-Ser.					peroxisome	nucleotide binding|RNA binding				0						AGATGCAGGACGAGCTGGAGT	0.507													T	15690712	T	T	15690712	2	4	175	1	0	0	0	0	0	0	0	1	8177	523	19	1		1	KIAA0430	16	15690712	Silent	SNP	C	TCGA-26-5133-01A-01D-1486-08	14962849	15690712	74664041	54	12485											
ITGAX	3687	broad.mit.edu	37	chr16	31388543	31388543	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccagcaagaccaccttccagCtggagctcccggtgaagtat	10	14	0	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr16:31388543C>A	uc002ebu.1	+	23	2813	c.2746C>A	c.(2746-2748)CTG>ATG	p.L916M	ITGAX_uc002ebt.2_Missense_Mutation_p.L916M	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	916	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CACCTTCCAGCTGGAGCTCCC	0.537													A	31388543	A	A	31388543	3	1	175	1	0	0	0	0	1	0	0	0	7889	796	28	5	2836	5	ITGAX	16	31388543	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	15697831	31388543	58966210	55	12486											
TP53	7157	broad.mit.edu	37	chr17	7577580	7577580	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aactgttacacatgtagttgTagtggatggtggtacagtca	12	5	1	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr17:7577580T>C	uc002gim.2	-	7	895	c.701A>G	c.(700-702)TAC>TGC	p.Y234C	TP53_uc002gig.1_Missense_Mutation_p.Y234C|TP53_uc002gih.2_Missense_Mutation_p.Y234C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y102C|TP53_uc010cng.1_Missense_Mutation_p.Y102C|TP53_uc002gii.1_Missense_Mutation_p.Y102C|TP53_uc010cnh.1_Missense_Mutation_p.Y234C|TP53_uc010cni.1_Missense_Mutation_p.Y234C|TP53_uc002gij.2_Missense_Mutation_p.Y234C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y141C|TP53_uc002gio.2_Missense_Mutation_p.Y102C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	234	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> F (in a sporadic cancer; somatic mutation).|Y -> K (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|Y -> N (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> Q (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y234C(70)|p.Y234H(13)|p.Y234N(11)|p.0?(7)|p.Y234S(6)|p.Y234*(4)|p.Y234D(3)|p.Y234del(3)|p.Y234fs*2(1)|p.V225fs*23(1)|p.Y234fs*6(1)|p.Y234fs*5(1)|p.Y234fs*4(1)|p.Y234R(1)|p.Y234Y(1)|p.H233_C242del10(1)|p.D228fs*12(1)|p.Y234F(1)|p.I232_Y236delIHYNY(1)|p.Y141S(1)|p.T230_Y234delTTIHY(1)|p.H233fs*6(1)|p.Y234_N235insX(1)|p.I232fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGTAGTTGTAGTGGATGGT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7577580	C	C	7577580	3	2	175	1	0	0	0	0	1	0	0	0	16378	1638	57	4	589	4	TP53	17	7577580	Missense_Mutation	SNP	T	TCGA-26-5133-01A-01D-1486-08		7577580	73617630	56	12487											
NF1	4763	broad.mit.edu	37	chr17	29667528	29667528	+	Frame_Shift_Del	DEL	G	-	-													tatcttctttgccaggactcGcctctgcacaaagccctctt							TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr17:29667528delG	uc002hgg.2	+	47	7260	c.6927delG	c.(6925-6927)TCGfs	p.S2309fs	NF1_uc002hgh.2_Frame_Shift_Del_p.S2288fs|NF1_uc010cso.2_Frame_Shift_Del_p.S497fs|NF1_uc010wbt.1_5'UTR|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2309					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GCCAGGACTCGCCTCTGCACA	0.443			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29667528	-	-	29667528	7	5	175	1	0	1	0	1	0	0	0	0	10356	1074	38	0	7174	0	NF1	17	29667528	Frame_Shift_Del	DEL	G	TCGA-26-5133-01A-01D-1486-08	22089948	29667528	51527682	57	12488											
KRT31	3881	broad.mit.edu	37	chr17	39551111	39551111	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtactcacttgcagtcctcGctctccagcaggctccggta	9	15	2	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr17:39551111G>A	uc002hwn.2	-	6	1139	c.1086C>T	c.(1084-1086)AGC>AGT	p.S362S	KRT31_uc010cxn.2_Silent_p.S362S	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	362	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				TGCAGTCCTCGCTCTCCAGCA	0.532													A	39551111	A	A	39551111	2	1	175	1	0	0	0	0	0	0	0	1	8467	1078	38	1		1	KRT31	17	39551111	Silent	SNP	G	TCGA-26-5133-01A-01D-1486-08	9883583	39551111	41644099	58	12489											
MMD	23531	broad.mit.edu	37	chr17	53471726	53471726	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcataaagtccgtaggacttCggtaaaggtatttccaaatg	10	7	0	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr17:53471726C>T	uc002iui.2	-	7	971	c.686G>A	c.(685-687)CGA>CAA	p.R229Q		NM_012329	NP_036461	Q15546	PAQRB_HUMAN	monocyte to macrophage	229	Lumenal (Potential).				cytolysis	integral to plasma membrane|late endosome membrane|lysosomal membrane|membrane fraction	receptor activity				0						CGTAGGACTTCGGTAAAGGTA	0.463													T	53471726	T	T	53471726	3	4	175	1	0	0	0	0	1	0	0	0	9643	884	31	2	34	2	MMD	17	53471726	Missense_Mutation	SNP	C	TCGA-26-5133-01A-01D-1486-08	13920615	53471726	27723484	59	12490											
KCNH6	81033	broad.mit.edu	37	chr17	61611547	61611547	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccgcaccacctatgtcaacAccaatgatgaggtggtcagc	9	13	2	2			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr17:61611547A>G	uc002jay.2	+	5	1056	c.976A>G	c.(976-978)ACC>GCC	p.T326A	KCNH6_uc002jax.1_Missense_Mutation_p.T326A|KCNH6_uc010wpl.1_Missense_Mutation_p.T203A|KCNH6_uc010wpm.1_Missense_Mutation_p.T326A|KCNH6_uc002jaz.1_Missense_Mutation_p.T326A	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	326	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CTATGTCAACACCAATGATGA	0.567													G	61611547	G	G	61611547	3	3	175	1	0	0	0	0	1	0	0	0	8036	159	6	4	994	4	KCNH6	17	61611547	Missense_Mutation	SNP	A	TCGA-26-5133-01A-01D-1486-08	8139821	61611547	19583663	60	12491											
DNMT1	1786	broad.mit.edu	37	chr19	10288042	10288042	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctggggctaggtgaaggttcAgctgtttaaagaagaaaaag	14	4	1	3			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr19:10288042A>G	uc002mng.2	-	5	627	c.447T>C	c.(445-447)CCT>CCC	p.P149P	DNMT1_uc010xlc.1_Silent_p.A165A|DNMT1_uc002mnh.2_Silent_p.A44A|DNMT1_uc010xld.1_Silent_p.P149P|DNMT1_uc010dxb.1_RNA	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	149	Interaction with DNMT3B.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GTGAAGGTTCAGCTGTTTAAA	0.398													G	10288042	G	G	10288042	2	3	175	1	0	0	0	0	0	0	0	1	4675	202	7	4		4	DNMT1	19	10288042	Silent	SNP	A	TCGA-26-5133-01A-01D-1486-08		10288042	48840941	61	12492											
PLEKHG2	64857	broad.mit.edu	37	chr19	39915859	39915859	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtccggttgaaccaccctgcTctcttggcctccacacagga	9	16	1	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr19:39915859T>G	uc010xuz.1	+	19	4411	c.4086T>G	c.(4084-4086)GCT>GCG	p.A1362A	PLEKHG2_uc010xuy.1_Intron|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Silent_p.A1140A	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1362					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			ACCACCCTGCTCTCTTGGCCT	0.652													G	39915859	G	G	39915859	2	3	175	1	0	0	0	0	0	0	0	1	12069	1538	54	5		5	PLEKHG2	19	39915859	Silent	SNP	T	TCGA-26-5133-01A-01D-1486-08	29627817	39915859	19213124	62	12493											
NLRP13	126204	broad.mit.edu	37	chr19	56423467	56423467	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttctttgtcaagcaagacGtgttgcagtaacatcttcat	8	9	4	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr19:56423467G>A	uc010ygg.1	-	5	1741	c.1716C>T	c.(1714-1716)CAC>CAT	p.H572H		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	572							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAAGCAAGACGTGTTGCAGTA	0.423													A	56423467	A	A	56423467	2	1	175	1	0	0	0	0	0	0	0	1	10475	1136	40	1		1	NLRP13	19	56423467	Silent	SNP	G	TCGA-26-5133-01A-01D-1486-08	16507608	56423467	2705516	63	12494											
COL18A1	80781	broad.mit.edu	37	chr21	46875768	46875768	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgccagaggagaacattgcCggtgtcggagccgagatcct	15	11	0	3			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chr21:46875768C>T	uc011afs.1	+	1	345	c.324C>T	c.(322-324)GCC>GCT	p.A108A	COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Silent_p.A108A	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	108					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		AGAACATTGCCGGTGTCGGAG	0.642													T	46875768	T	T	46875768	2	4	175	1	0	0	0	0	0	0	0	1	3675	639	23	2		2	COL18A1	21	46875768	Silent	SNP	C	TCGA-26-5133-01A-01D-1486-08		46875768	1254127	64	12495											
SFRS17A	8227	broad.mit.edu	37	chrX	1719770	1719770	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacacacacgacgagctgggCgtggcacacgccgacctgct	12	16	0	0			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chrX:1719770C>T	uc004cqa.2	+	5	1567	c.1371C>T	c.(1369-1371)GGC>GGT	p.G457G	SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	457					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACGAGCTGGGCGTGGCACACG	0.701													T	1719770	T	T	1719770	2	4	175	1	0	0	0	0	0	0	0	1	14173	755	27	1		1	SFRS17A	23	1719770	Silent	SNP	C	TCGA-26-5133-01A-01D-1486-08		1719770	153550790	65	12496											
CITED1	4435	broad.mit.edu	37	chrX	71522708	71522708	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acatcaagtgcaggcctcgaCgttgttggcatttcagagcc	11	11	2	1	rs146201846	byFrequency	TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chrX:71522708C>T	uc011mqd.1	-	2	167	c.12G>A	c.(10-12)ACG>ACA	p.T4T	CITED1_uc011mqc.1_Silent_p.T30T|CITED1_uc004eas.2_Silent_p.T4T|CITED1_uc004eat.2_Silent_p.T4T	NM_001144887	NP_001138359	Q99966	CITE1_HUMAN	melanocyte-specific gene 1 isoform 1	4					apoptosis|branching involved in ureteric bud morphogenesis|cell proliferation|melanin biosynthetic process|melanocyte differentiation|mesenchymal to epithelial transition|metanephros development|negative regulation of neuron apoptosis|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|nucleocytoplasmic transport|placenta development|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to cAMP|response to estrogen stimulus|response to insulin stimulus|response to interferon-gamma|response to interleukin-1|response to interleukin-11|response to interleukin-2|response to interleukin-4|response to interleukin-6|response to interleukin-9|response to lipopolysaccharide|response to parathyroid hormone stimulus|response to transforming growth factor beta stimulus|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	chromatin binding|co-SMAD binding|LBD domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding				0	Renal(35;0.156)					CAGGCCTCGACGTTGTTGGCA	0.428													T	71522708	T	T	71522708	2	4	175	1	0	0	0	0	0	0	0	1	3439	523	19	1		1	CITED1	23	71522708	Silent	SNP	C	TCGA-26-5133-01A-01D-1486-08	69802938	71522708	83747852	66	12497											
CHRDL1	91851	broad.mit.edu	37	chrX	109922648	109922648	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ctcaatatggaagtgctggaGaatgcctagggccaagcaaa	12	8	1	1			TCGA-26-5133-01A-01D-1486-08	TCGA-26-5133-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	533051f3-5ea5-41a4-8727-11dc6d786607	c47b3f6f-5f47-4588-afe6-0249eaefe1b5	g.chrX:109922648G>C	uc004eou.3	-	11	1511	c.1162C>G	c.(1162-1164)CTC>GTC	p.L388V	CHRDL1_uc004eov.2_Missense_Mutation_p.L377V|CHRDL1_uc004eow.2_Missense_Mutation_p.L386V|CHRDL1_uc010nps.2_Missense_Mutation_p.L387V|CHRDL1_uc004eot.2_Missense_Mutation_p.L307V|CHRDL1_uc011mss.1_Missense_Mutation_p.L302V	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	380					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						AAGTGCTGGAGAATGCCTAGG	0.453													C	109922648	C	C	109922648	3	2	175	1	0	0	0	0	1	0	0	0	3373	942	33	5	222	5	CHRDL1	23	109922648	Missense_Mutation	SNP	G	TCGA-26-5133-01A-01D-1486-08	38399940	109922648	45347912	67	12498											
GALE	2582	broad.mit.edu	37	chr1	24123528	24123528	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttcccttttgccttacctggGagacataaggcatgaggttg	11	9	0	2			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr1:24123528G>A	uc009vqo.1	-	6	848	c.638C>T	c.(637-639)TCC>TTC	p.S213F	GALE_uc001bhv.1_Missense_Mutation_p.S213F|GALE_uc001bhw.1_Missense_Mutation_p.S213F|GALE_uc001bhx.1_Missense_Mutation_p.S213F|GALE_uc009vqp.1_Missense_Mutation_p.S213F|GALE_uc001bhy.1_Missense_Mutation_p.S213F|GALE_uc001bhz.1_Missense_Mutation_p.S139F|GALE_uc001bia.2_Missense_Mutation_p.S5F	NM_001127621	NP_001121093	Q14376	GALE_HUMAN	UDP-galactose-4-epimerase	213					galactose catabolic process	cytosol	coenzyme binding|protein homodimerization activity|UDP-glucose 4-epimerase activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		CCTTACCTGGGAGACATAAGG	0.587													A	24123528	A	A	24123528	3	1	176	1	0	0	0	0	1	0	0	0	6202	1174	41	3	432	3	GALE	1	24123528	Missense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08		24123528	225127093	1	12499											
MFSD2A	84879	broad.mit.edu	37	chr1	40431623	40431623	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttgtttccaggacctcaaTagctctacagtagcttcaca	6	13	3	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr1:40431623T>C	uc001cev.2	+	6	871	c.690T>C	c.(688-690)AAT>AAC	p.N230N	MFSD2A_uc010ojb.1_Silent_p.N180N|MFSD2A_uc001ceu.2_Silent_p.N217N|MFSD2A_uc010ojc.1_Silent_p.N61N|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_5'Flank	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	230					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						AGGACCTCAATAGCTCTACAG	0.572													C	40431623	C	C	40431623	2	2	176	1	0	0	0	0	0	0	0	1	9530	1403	49	4		4	MFSD2A	1	40431623	Silent	SNP	T	TCGA-26-5134-01A-01D-1486-08	16308095	40431623	208818998	2	12500											
CYP4Z1	199974	broad.mit.edu	37	chr1	47583502	47583502	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtggcattaactctgctcCgcttcaagctggctccagac	9	14	2	1	rs145758676		TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr1:47583502C>T	uc001cqu.1	+	12	1417	c.1414C>T	c.(1414-1416)CGC>TGC	p.R472C		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	472	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						AACTCTGCTCCGCTTCAAGCT	0.468													T	47583502	T	T	47583502	3	4	176	1	0	0	0	0	1	0	0	0	4194	652	23	2	1460	2	CYP4Z1	1	47583502	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	7151879	47583502	201667119	3	12501											
ROCK2	9475	broad.mit.edu	37	chr2	11332301	11332301	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtttggggcaagctgtcgaCttggccgtctaatagactgg	14	8	1	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr2:11332301C>T	uc002rbd.1	-	32	4585	c.4136G>A	c.(4135-4137)AGT>AAT	p.S1379N		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	1379					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AAGCTGTCGACTTGGCCGTCT	0.368													T	11332301	T	T	11332301	3	4	176	1	0	0	0	0	1	0	0	0	13518	565	20	3	38	3	ROCK2	2	11332301	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08		11332301	231867072	4	12502											
ITSN2	50618	broad.mit.edu	37	chr2	24526701	24526701	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gctgagtttgagaaagatttGactgaagaagggcatttcta	12	4	1	6			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr2:24526701G>A	uc002rfe.2	-	9	1082	c.824C>T	c.(823-825)TCA>TTA	p.S275L	ITSN2_uc002rff.2_Missense_Mutation_p.S275L|ITSN2_uc002rfg.2_Missense_Mutation_p.S275L|ITSN2_uc010eyd.2_Missense_Mutation_p.S300L	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	275	EH 2.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAAAGATTTGACTGAAGAAG	0.318													A	24526701	A	A	24526701	3	1	176	1	0	0	0	0	1	0	0	0	7927	1294	45	3	4448	3	ITSN2	2	24526701	Missense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08	13194400	24526701	218672672	5	12503											
EIF2AK2	5610	broad.mit.edu	37	chr2	37376027	37376027	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagctttgtccaaaatgcaCgcagataatcacggaagtgt	10	8	1	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr2:37376027C>T	uc010ynh.1	-	2	514	c.-43G>A	c.(-45--41)GCGTG>GCATG		EIF2AK2_uc010fab.1_5'Flank|EIF2AK2_uc010yng.1_5'Flank|EIF2AK2_uc010fac.2_Translation_Start_Site|EIF2AK2_uc010fad.2_Translation_Start_Site	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha						evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				CCAAAATGCACGCAGATAATC	0.433													T	37376027	T	T	37376027	1	4	176	1	0	0	0	0	0	0	0	0	4997	551	19	1		1	EIF2AK2	2	37376027	Translation_Start_Site	SNP	C	TCGA-26-5134-01A-01D-1486-08	12849326	37376027	205823346	6	12504											
ZNF638	27332	broad.mit.edu	37	chr2	71577393	71577393	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tgtgtaacgtagaatgtagtCatttgaaggtgagtgttttt	12	2	1	3			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr2:71577393C>A	uc002shx.2	+	2	1628	c.1309C>A	c.(1309-1311)CAT>AAT	p.H437N	ZNF638_uc010fec.2_Missense_Mutation_p.H543N|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Missense_Mutation_p.H437N|ZNF638_uc002shy.2_Missense_Mutation_p.H437N|ZNF638_uc002shz.2_Missense_Mutation_p.H437N|ZNF638_uc002sia.2_Missense_Mutation_p.H437N|ZNF638_uc002sib.1_Missense_Mutation_p.H437N	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	437					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						AGAATGTAGTCATTTGAAGGT	0.358													A	71577393	A	A	71577393	3	1	176	1	0	0	0	0	1	0	0	0	18052	826	29	5	1311	5	ZNF638	2	71577393	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	34201366	71577393	171621980	7	12505											
ADRA2B	151	broad.mit.edu	37	chr2	96781837	96781837	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaatgaggaaggtgatggCcgccgctatggccgctgtgg	18	8	0	3			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr2:96781837C>T	uc002svi.2	-	1	52	c.52G>A	c.(52-54)GCC>ACC	p.A18T		NM_000682	NP_000673	P18089	ADA2B_HUMAN	alpha-2B-adrenergic receptor	18	Helical; Name=1; (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			ovary(2)|lung(1)	3					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	AAGGTGATGGCCGCCGCTATG	0.662													T	96781837	T	T	96781837	3	4	176	1	0	0	0	0	1	0	0	0	338	739	26	3	1295	3	ADRA2B	2	96781837	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	25204444	96781837	146417536	8	12506											
WIPF1	7456	broad.mit.edu	37	chr2	175432647	175432647	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttgatggtggaggtgggggAggtgccccagcactgggcct	20	8	0	1	rs34236584		TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr2:175432647A>C	uc002uiy.2	-	7	1616	c.1284T>G	c.(1282-1284)CCT>CCG	p.P428P	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Silent_p.P428P|WIPF1_uc010fqt.1_Silent_p.P428P|WIPF1_uc002uiz.2_Silent_p.P428P|WIPF1_uc002ujb.1_Silent_p.P428P	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	428	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GAGGTGGGGGAGGTGCCCCAG	0.587													C	175432647	C	C	175432647	2	2	176	1	0	0	0	0	0	0	0	1	17364	291	11	5		5	WIPF1	2	175432647	Silent	SNP	A	TCGA-26-5134-01A-01D-1486-08	78650810	175432647	67766726	9	12507											
KIF15	56992	broad.mit.edu	37	chr3	44882590	44882590	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctaagacaccacctcactttCaaacacatttggcaaaactc	3	14	2	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr3:44882590C>G	uc003cnx.3	+	29	3594	c.3445C>G	c.(3445-3447)CAA>GAA	p.Q1149E	KIF15_uc010hiq.2_Missense_Mutation_p.Q1052E|KIF15_uc010hir.2_Missense_Mutation_p.Q197E	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	1149	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		ACCTCACTTTCAAACACATTT	0.333													G	44882590	G	G	44882590	3	3	176	1	0	0	0	0	1	0	0	0	8277	827	29	5	3559	5	KIF15	3	44882590	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08		44882590	153139840	10	12508											
SETD2	29072	broad.mit.edu	37	chr3	47147485	47147485	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaacatatccaagctgcttAcctcatcattcttcagggcc	5	14	4	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr3:47147485A>G	uc003cqs.2	-	6	4892	c.4839_splice	c.e6+1	p.E1613_splice	SETD2_uc003cqv.2_Splice_Site_p.E1602_splice	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CAAGCTGCTTACCTCATCATT	0.338			N|F|S|Mis		clear cell renal carcinoma								G	47147485	G	G	47147485	5	3	176	1	0	0	0	0	0	0	1	0	14131	405	14	4	2917	4	SETD2	3	47147485	Splice_Site	SNP	A	TCGA-26-5134-01A-01D-1486-08	2264895	47147485	150874945	11	12509											
UQCRC1	7384	broad.mit.edu	37	chr3	48641675	48641675	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaactctcacctgacattcTcactgggcccctccacagcc	5	20	2	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr3:48641675T>C	uc003cub.1	-	5	662	c.617A>G	c.(616-618)GAG>GGG	p.E206G	UQCRC1_uc003cua.1_Missense_Mutation_p.E91G|UQCRC1_uc003cuc.1_Missense_Mutation_p.E206G|UQCRC1_uc003cud.1_Missense_Mutation_p.E206G	NM_003365	NP_003356	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	206					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	CCTGACATTCTCACTGGGCCC	0.552													C	48641675	C	C	48641675	3	2	176	1	0	0	0	0	1	0	0	0	17016	1551	54	4	861	4	UQCRC1	3	48641675	Missense_Mutation	SNP	T	TCGA-26-5134-01A-01D-1486-08	1494190	48641675	149380755	12	12510											
MECOM	2122	broad.mit.edu	37	chr3	168810761	168810761	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttacctctcctccacattcCtgggagattggctgccatgg	9	13	1	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr3:168810761C>T	uc003ffi.3	-	13	2854	c.2585G>A	c.(2584-2586)AGG>AAG	p.R862K	MECOM_uc010hwk.1_Missense_Mutation_p.R876K|MECOM_uc003ffj.3_Missense_Mutation_p.R927K|MECOM_uc011bpi.1_Missense_Mutation_p.R854K|MECOM_uc003ffn.3_Missense_Mutation_p.R862K|MECOM_uc003ffk.2_Missense_Mutation_p.R853K|MECOM_uc003ffl.2_Missense_Mutation_p.R1013K|MECOM_uc011bpj.1_Missense_Mutation_p.R1050K|MECOM_uc011bpk.1_Missense_Mutation_p.R852K	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	862					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CTCCACATTCCTGGGAGATTG	0.403													T	168810761	T	T	168810761	3	4	176	1	0	0	0	0	1	0	0	0	9422	681	24	3	586	3	MECOM	3	168810761	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	120169086	168810761	29211669	13	12511											
SAMD7	344658	broad.mit.edu	37	chr3	169656173	169656173	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcctataagacaagcatttgAtcaaccagcagatacatccc	5	12	1	3			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr3:169656173A>G	uc003fgd.2	+	9	1487	c.1220A>G	c.(1219-1221)GAT>GGT	p.D407G	SAMD7_uc003fge.2_Missense_Mutation_p.D407G|SAMD7_uc011bpo.1_Missense_Mutation_p.D308G	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	407										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			CAAGCATTTGATCAACCAGCA	0.348													G	169656173	G	G	169656173	3	3	176	1	0	0	0	0	1	0	0	0	13824	333	12	4	1246	4	SAMD7	3	169656173	Missense_Mutation	SNP	A	TCGA-26-5134-01A-01D-1486-08	845412	169656173	28366257	14	12512											
PDGFRA	5156	broad.mit.edu	37	chr4	55133888	55133899	+	In_Frame_Del	DEL	GGAAAAGATTCA	-	-													actgagatcaccactgatgtGgaaaagattcaggaaataag							TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr4:55133888_55133899delGGAAAAGATTCA	uc003han.3	+	7	1432_1443	c.1101_1112delGGAAAAGATTCA	c.(1099-1113)GTGGAAAAGATTCAG>GTG	p.EKIQ368del	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_In_Frame_Del_p.EKIQ262del|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	368_371	Ig-like C2-type 4.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CCACTGATGTGGAAAAGATTCAGGAAATAAGG	0.448			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			-	55133899	-	-	55133888	7	5	176	1	0	1	0	1	0	0	0	0	11661	1335	47	0	1123	0	PDGFRA	4	55133888	In_Frame_Del	DEL	GGAAAAGATTCA	TCGA-26-5134-01A-01D-1486-08		55133888	136020388	15	12513											
ENAM	10117	broad.mit.edu	37	chr4	71509712	71509712	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acttcatcccaccaagttacCcatcaggtcaaaaagaagca	5	13	3	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr4:71509712C>A	uc011caw.1	+	9	2850	c.2569C>A	c.(2569-2571)CCA>ACA	p.P857T		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	857					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			ACCAAGTTACCCATCAGGTCA	0.448													A	71509712	A	A	71509712	3	1	176	1	0	0	0	0	1	0	0	0	5112	623	22	5	2599	5	ENAM	4	71509712	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	16375824	71509712	119644564	16	12514											
PTPN13	5783	broad.mit.edu	37	chr4	87728883	87728883	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaaaaatccacagtgataGccatgatgactcaagaagta	8	8	1	4			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr4:87728883G>A	uc003hpz.2	+	45	7396	c.6916G>A	c.(6916-6918)GCC>ACC	p.A2306T	PTPN13_uc003hpy.2_Missense_Mutation_p.A2311T|PTPN13_uc003hqa.2_Missense_Mutation_p.A2287T|PTPN13_uc003hqb.2_Missense_Mutation_p.A2115T	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2306	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CACAGTGATAGCCATGATGAC	0.453													A	87728883	A	A	87728883	3	1	176	1	0	0	0	0	1	0	0	0	12782	971	34	3	7105	3	PTPN13	4	87728883	Missense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08	16219171	87728883	103425393	17	12515											
ADH1A	124	broad.mit.edu	37	chr4	100205753	100205753	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctgctggtgccatcctgcaGggtcccctgaggattgctta	12	13	0	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr4:100205753G>T	uc003hur.1	-	5	441	c.370C>A	c.(370-372)CTG>ATG	p.L124M	uc003hum.1_Intron|ADH1A_uc011ceg.1_Missense_Mutation_p.L124M|ADH1A_uc010ilf.1_Translation_Start_Site	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	124					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CCATCCTGCAGGGTCCCCTGA	0.517													T	100205753	T	T	100205753	3	4	176	1	0	0	0	0	1	0	0	0	307	991	35	5	777	5	ADH1A	4	100205753	Missense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08	12476870	100205753	90948523	18	12516											
PRMT10	90826	broad.mit.edu	37	chr4	148589774	148589774	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taactttcccatacttttcaCaattagcactttcacctttg	2	12	2	0	rs147339843	byFrequency	TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr4:148589774C>A	uc003ilc.2	-	6	1011	c.869G>T	c.(868-870)TGT>TTT	p.C290F	PRMT10_uc003ild.2_Missense_Mutation_p.C177F	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	290						cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						ATACTTTTCACAATTAGCACT	0.299													A	148589774	A	A	148589774	3	1	176	1	0	0	0	0	1	0	0	0	12536	478	17	5	1696	5	PRMT10	4	148589774	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	48384021	148589774	42564502	19	12517											
FGA	2243	broad.mit.edu	37	chr4	155508053	155508053	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gaccctcgacaagatcggatCttaatatcaatgtccaccta	6	12	2	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr4:155508053C>G	uc003iod.1	-	5	586	c.528G>C	c.(526-528)AAG>AAC	p.K176N	FGA_uc003ioe.1_Missense_Mutation_p.K176N|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	176	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AAGATCGGATCTTAATATCAA	0.393													G	155508053	G	G	155508053	3	3	176	1	0	0	0	0	1	0	0	0	5830	912	32	5	2124	5	FGA	4	155508053	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	6918279	155508053	35646223	20	12518											
PCDHA7	56141	broad.mit.edu	37	chr5	140215867	140215867	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tacactggtgagatcagcacGacacgagccctagatgagac	11	11	1	3			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr5:140215867G>A	uc003lhq.2	+	1	1899	c.1899G>A	c.(1897-1899)ACG>ACA	p.T633T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.T633T	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	633	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGATCAGCACGACACGAGCCC	0.647													A	140215867	A	A	140215867	2	1	176	1	0	0	0	0	0	0	0	1	11529	1045	37	2		2	PCDHA7	5	140215867	Silent	SNP	G	TCGA-26-5134-01A-01D-1486-08		140215867	40699393	21	12519											
TRIM15	89870	broad.mit.edu	37	chr6	30131441	30131441	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgaggagaccggagtggaCgggctggggaaggcaccgtg	21	8	0	2			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr6:30131441C>T	uc010jrx.2	+	1	459	c.-20C>T	c.(-22--18)GACGG>GATGG		TRIM10_uc003npn.2_5'Flank|TRIM10_uc003npo.3_5'Flank	NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15						mesodermal cell fate determination	intracellular	zinc ion binding				0						CCGGAGTGGACGGGCTGGGGA	0.602													T	30131441	T	T	30131441	1	4	176	1	0	0	0	0	0	0	0	0	16487	551	19	1		1	TRIM15	6	30131441	Translation_Start_Site	SNP	C	TCGA-26-5134-01A-01D-1486-08		30131441	140983626	22	12520											
HSPA1L	3305	broad.mit.edu	37	chr6	31778907	31778907	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaatcaatttctaggttggcCtgggtgctggacgacagggt	15	7	2	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr6:31778907C>A	uc003nxh.2	-	2	1026	c.843G>T	c.(841-843)CAG>CAT	p.Q281H	HSPA1L_uc010jte.2_Missense_Mutation_p.Q281H	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	281					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						CTAGGTTGGCCTGGGTGCTGG	0.522													A	31778907	A	A	31778907	3	1	176	1	0	0	0	0	1	0	0	0	7410	680	24	5	1086	5	HSPA1L	6	31778907	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	1647466	31778907	139336160	23	12521											
PKHD1	5314	broad.mit.edu	37	chr6	51484145	51484145	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	caggtacacctgctgagcagGagcacctggagcacagatgt	13	11	0	2			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr6:51484145G>C	uc003pah.1	-	67	12235	c.11959C>G	c.(11959-11961)CCT>GCT	p.P3987A		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3987	Cytoplasmic (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TGCTGAGCAGGAGCACCTGGA	0.572													C	51484145	C	C	51484145	3	2	176	1	0	0	0	0	1	0	0	0	11971	1174	41	5	269	5	PKHD1	6	51484145	Missense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08	19705238	51484145	119630922	24	12522											
MTHFD1L	25902	broad.mit.edu	37	chr6	151281413	151281413	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtttgggctggttcaggcGcagtttgacatcgcagtggc	16	8	1	1	rs146093887	by1000genomes	TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr6:151281413G>A	uc003qob.2	+	18	2074	c.1806G>A	c.(1804-1806)GCG>GCA	p.A602A	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Silent_p.A603A|MTHFD1L_uc003qoc.2_Silent_p.A550A	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	602	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		TGGTTCAGGCGCAGTTTGACA	0.612													A	151281413	A	A	151281413	2	1	176	1	0	0	0	0	0	0	0	1	9928	1074	38	1		1	MTHFD1L	6	151281413	Silent	SNP	G	TCGA-26-5134-01A-01D-1486-08	99797268	151281413	19833654	25	12523											
PCLO	27445	broad.mit.edu	37	chr7	82785272	82785272	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agtgccatcctgctgaagcgGatccctaccaggtccttgct	10	14	0	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr7:82785272G>T	uc003uhx.2	-	2	974	c.685C>A	c.(685-687)CCG>ACG	p.P229T	PCLO_uc003uhv.2_Missense_Mutation_p.P229T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	229	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGCTGAAGCGGATCCCTACCA	0.463													T	82785272	T	T	82785272	3	4	176	1	0	0	0	0	1	0	0	0	11583	1174	41	5	14856	5	PCLO	7	82785272	Missense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08		82785272	76353391	26	12524											
TFPI2	7980	broad.mit.edu	37	chr7	93519537	93519537	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccccgtacaggaactggcgGcagctctgcgtgtacctgtc	12	15	1	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr7:93519537G>A	uc003umy.1	-	2	258	c.183C>T	c.(181-183)TGC>TGT	p.C61C	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_Silent_p.C61C|TFPI2_uc003una.1_Silent_p.C50C|TFPI2_uc003unb.1_Silent_p.C61C|TFPI2_uc010lfg.1_Intron	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	61	BPTI/Kunitz inhibitor 1.				blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			GGAACTGGCGGCAGCTCTGCG	0.577													A	93519537	A	A	93519537	2	1	176	1	0	0	0	0	0	0	0	1	15806	1195	42	3		3	TFPI2	7	93519537	Silent	SNP	G	TCGA-26-5134-01A-01D-1486-08	10734265	93519537	65619126	27	12525											
MOGAT3	346606	broad.mit.edu	37	chr7	100841600	100841600	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggcctgcccgagctggggCtgggacaggatgaagtccag	17	11	0	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr7:100841600C>T	uc003uyc.2	-	5	707	c.540G>A	c.(538-540)CAG>CAA	p.Q180Q	MOGAT3_uc010lhr.2_Silent_p.Q180Q	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	180					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					CGAGCTGGGGCTGGGACAGGA	0.657													T	100841600	T	T	100841600	2	4	176	1	0	0	0	0	0	0	0	1	9696	796	28	3		3	MOGAT3	7	100841600	Silent	SNP	C	TCGA-26-5134-01A-01D-1486-08	7322063	100841600	58297063	28	12526											
KCNU1	157855	broad.mit.edu	37	chr8	36661576	36661576	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctttgtactaagcattgggtCtcttataatctatttcatca	5	8	4	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr8:36661576C>G	uc010lvw.2	+	3	434	c.347C>G	c.(346-348)TCT>TGT	p.S116C	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	116	Helical; Name=Segment S1; (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AGCATTGGGTCTCTTATAATC	0.358													G	36661576	G	G	36661576	3	3	176	1	0	0	0	0	1	0	0	0	8093	913	32	5	357	5	KCNU1	8	36661576	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08		36661576	109702446	29	12527											
SNX16	64089	broad.mit.edu	37	chr8	82714627	82714627	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttatatacctagattcttcaTccaggacatcttgatcaacc	4	11	4	2			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr8:82714627T>A	uc011lft.1	-	8	1433	c.926A>T	c.(925-927)GAT>GTT	p.D309V	SNX16_uc003ycn.2_Missense_Mutation_p.D309V|SNX16_uc003yco.2_Missense_Mutation_p.D280V	NM_022133	NP_071416	P57768	SNX16_HUMAN	sorting nexin 16 isoform a	309				LDEE -> WMR (in Ref. 1; AAG25676).	cell communication|early endosome to late endosome transport|endosome to lysosome transport|protein targeting to lysosome	early endosome membrane|extrinsic to endosome membrane|late endosome membrane|lysosome	identical protein binding|phosphatidylinositol binding			ovary(1)|pancreas(1)	2						AGATTCTTCATCCAGGACATC	0.343													A	82714627	A	A	82714627	3	1	176	1	0	0	0	0	1	0	0	0	14887	1435	50	5	116	5	SNX16	8	82714627	Missense_Mutation	SNP	T	TCGA-26-5134-01A-01D-1486-08	46053051	82714627	63649395	30	12528											
TAF1L	138474	broad.mit.edu	37	chr9	32635178	32635178	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcatcataatccgagtggtAaaggggctgcaagctcccca	10	11	2	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr9:32635178A>G	uc003zrg.1	-	1	490	c.400T>C	c.(400-402)TAC>CAC	p.Y134H	uc003zrh.1_Intron	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	134					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCCGAGTGGTAAAGGGGCTGC	0.478													G	32635178	G	G	32635178	3	3	176	1	0	0	0	0	1	0	0	0	15520	362	13	4	5084	4	TAF1L	9	32635178	Missense_Mutation	SNP	A	TCGA-26-5134-01A-01D-1486-08		32635178	108578253	31	12529											
PIGO	84720	broad.mit.edu	37	chr9	35090223	35090223	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggggctgctgtctcttcCgcagcccttgactctcacac	10	16	2	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr9:35090223C>T	uc003zwd.2	-	9	3305	c.2909G>A	c.(2908-2910)CGG>CAG	p.R970Q	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Missense_Mutation_p.R553Q|PIGO_uc003zwf.2_Missense_Mutation_p.R553Q|PIGO_uc003zwg.1_3'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	970					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CTGTCTCTTCCGCAGCCCTTG	0.607													T	35090223	T	T	35090223	3	4	176	1	0	0	0	0	1	0	0	0	11894	652	23	2	372	2	PIGO	9	35090223	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	2455045	35090223	106123208	32	12530											
NR4A3	8013	broad.mit.edu	37	chr9	102590645	102590645	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caccaccaccaccaccaccaTcaccagcagcagcatcagca	4	21	2	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr9:102590645T>C	uc004baf.1	+	3	1050	c.321T>C	c.(319-321)CAT>CAC	p.H107H	NR4A3_uc004bae.2_Silent_p.H107H|NR4A3_uc004bag.1_Silent_p.H107H|NR4A3_uc004bai.2_Silent_p.H118H	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	107	Poly-His.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				accaccaccatcaccaGCAGC	0.493			T	EWSR1	extraskeletal myxoid chondrosarcoma								C	102590645	C	C	102590645	2	2	176	1	0	0	0	0	0	0	0	1	10634	1432	50	4		4	NR4A3	9	102590645	Silent	SNP	T	TCGA-26-5134-01A-01D-1486-08	67500422	102590645	38622786	33	12531											
ERCC6	2074	broad.mit.edu	37	chr10	50690803	50690803	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actgctccataaacacaggcAacgtgcctaactttcccggg	8	14	0	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr10:50690803A>G	uc001jhs.3	-	10	2253	c.2099T>C	c.(2098-2100)TTG>TCG	p.L700S	ERCC6_uc010qgr.1_Missense_Mutation_p.L70S|ERCC6_uc001jhr.3_Missense_Mutation_p.L100S	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	700					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						AAACACAGGCAACGTGCCTAA	0.483								Direct_reversal_of_damage|NER					G	50690803	G	G	50690803	3	3	176	1	0	0	0	0	1	0	0	0	5217	131	5	4	2430	4	ERCC6	10	50690803	Missense_Mutation	SNP	A	TCGA-26-5134-01A-01D-1486-08		50690803	84843944	34	12532											
NOC3L	64318	broad.mit.edu	37	chr10	96099659	96099659	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggcactggagtacaatctcaAcaccttcattggtagcacct	8	12	2	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr10:96099659A>G	uc001kjq.1	-	17	1887	c.1799T>C	c.(1798-1800)GTT>GCT	p.V600A		NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	600						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				TACAATCTCAACACCTTCATT	0.433													G	96099659	G	G	96099659	3	3	176	1	0	0	0	0	1	0	0	0	10514	43	2	4	623	4	NOC3L	10	96099659	Missense_Mutation	SNP	A	TCGA-26-5134-01A-01D-1486-08	45408856	96099659	39435088	35	12533											
OR4A16	81327	broad.mit.edu	37	chr11	55111268	55111268	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	actttataggactcactgtgGttgccaatggtggaataatt	10	6	1	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr11:55111268G>T	uc010rie.1	+	1	592	c.592G>T	c.(592-594)GTT>TTT	p.V198F		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						ACTCACTGTGGTTGCCAATGG	0.428													T	55111268	T	T	55111268	3	4	176	1	0	0	0	0	1	0	0	0	11041	1261	44	5	594	5	OR4A16	11	55111268	Missense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08		55111268	79895248	36	12534											
OR5I1	10798	broad.mit.edu	37	chr11	55703585	55703585	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ataaaactgcagggcacaccCataataggaaatagatttgt	8	7	0	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr11:55703585C>A	uc010ris.1	-	1	292	c.292G>T	c.(292-294)GGG>TGG	p.G98W		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGGGCACACCCATAATAGGAA	0.428													A	55703585	A	A	55703585	3	1	176	1	0	0	0	0	1	0	0	0	11164	594	21	5	655	5	OR5I1	11	55703585	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	592317	55703585	79302931	37	12535											
OR8K3	219473	broad.mit.edu	37	chr11	56085869	56085869	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaggcaccattatttgcAttgttcctcatgatctatgt	7	10	2	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr11:56085869A>G	uc010rjf.1	+	1	87	c.87A>G	c.(85-87)GCA>GCG	p.A29A		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CATTATTTGCATTGTTCCTCA	0.433													G	56085869	G	G	56085869	2	3	176	1	0	0	0	0	0	0	0	1	11244	204	8	4		4	OR8K3	11	56085869	Silent	SNP	A	TCGA-26-5134-01A-01D-1486-08	382284	56085869	78920647	38	12536											
C11orf2	738	broad.mit.edu	37	chr11	64876151	64876151	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagatcgtggaacgagtggCccgcgagcgcctgggccacc	17	13	0	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr11:64876151C>T	uc001ocr.1	+	5	1248	c.1208C>T	c.(1207-1209)GCC>GTC	p.A403V	C11orf2_uc001ocs.1_Missense_Mutation_p.A279V	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	403					lipid transport|protein transport	Golgi apparatus|integral to membrane					0						GAACGAGTGGCCCGCGAGCGC	0.761													T	64876151	T	T	64876151	3	4	176	1	0	0	0	0	1	0	0	0	1633	739	26	3	1226	3	C11orf2	11	64876151	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	8790282	64876151	70130365	39	12537											
OR8D4	338662	broad.mit.edu	37	chr11	123777373	123777373	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gctattcttctgtcattaccCctaaaatgctatcagggttt	6	10	4	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr11:123777373C>A	uc010saa.1	+	1	235	c.235C>A	c.(235-237)CCT>ACT	p.P79T		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TGTCATTACCCCTAAAATGCT	0.358													A	123777373	A	A	123777373	3	1	176	1	0	0	0	0	1	0	0	0	11233	623	22	5	237	5	OR8D4	11	123777373	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	58901222	123777373	11229143	40	12538											
VSIG2	23584	broad.mit.edu	37	chr11	124618351	124618351	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctttctggaacctgaccagGcagaacgcagcaactgacag	10	12	2	3			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr11:124618351G>A	uc001qas.2	-	6	862	c.786C>T	c.(784-786)TGC>TGT	p.C262C	VSIG2_uc001qat.2_Silent_p.C262C	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	262	Helical; (Potential).					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		ACCTGACCAGGCAGAACGCAG	0.617													A	124618351	A	A	124618351	2	1	176	1	0	0	0	0	0	0	0	1	17221	1195	42	3		3	VSIG2	11	124618351	Silent	SNP	G	TCGA-26-5134-01A-01D-1486-08	840978	124618351	10388165	41	12539											
CD163L1	283316	broad.mit.edu	37	chr12	7527492	7527492	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtcagatacatttgcgaggCatggaaacagtggctgggtc	15	7	1	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr12:7527492C>A	uc001qsy.2	-	12	3055	c.3029G>T	c.(3028-3030)TGC>TTC	p.C1010F	CD163L1_uc010sge.1_Missense_Mutation_p.C1020F	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1010	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ATTTGCGAGGCATGGAAACAG	0.463											OREG0021653	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	7527492	A	A	7527492	3	1	176	1	0	0	0	0	1	0	0	0	2968	710	25	5	1364	5	CD163L1	12	7527492	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08		7527492	126324403	42	12540											
SFRS2IP	9169	broad.mit.edu	37	chr12	46357935	46357935	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccatatttagggtacataCagttttcttcttcatttctc	4	10	4	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr12:46357935C>T	uc001rox.2	-	2	303	c.16G>A	c.(16-18)GTA>ATA	p.V6I	SFRS2IP_uc001roy.1_Missense_Mutation_p.V70I|SFRS2IP_uc009zki.1_RNA|SFRS2IP_uc001roz.2_Missense_Mutation_p.V6I	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	6					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		AGGGTACATACAGTTTTCTTC	0.279													T	46357935	T	T	46357935	3	4	176	1	0	0	0	0	1	0	0	0	14177	478	17	3	4431	3	SFRS2IP	12	46357935	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	38830443	46357935	87493960	43	12541											
GRIP1	23426	broad.mit.edu	37	chr12	66773075	66773075	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttacccactggctgtggacCggtcccagtcttcataactc	8	15	2	0	rs145115262	by1000genomes	TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr12:66773075C>T	uc001stk.2	-	19	2691	c.2450G>A	c.(2449-2451)CGG>CAG	p.R817Q	GRIP1_uc010sta.1_Missense_Mutation_p.R761Q|GRIP1_uc001stj.2_Missense_Mutation_p.R599Q|GRIP1_uc001stl.1_Missense_Mutation_p.R709Q|GRIP1_uc001stm.2_Missense_Mutation_p.R817Q	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	869					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		GGCTGTGGACCGGTCCCAGTC	0.517													T	66773075	T	T	66773075	3	4	176	1	0	0	0	0	1	0	0	0	6787	652	23	2	804	2	GRIP1	12	66773075	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	20415140	66773075	67078820	44	12542											
LRRC43	254050	broad.mit.edu	37	chr12	122672375	122672375	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttggaaagtctctacgtcaCcgctaatcactggtaactcg	8	12	3	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr12:122672375C>T	uc009zxm.2	+	4	675	c.650C>T	c.(649-651)ACC>ATC	p.T217I	LRRC43_uc001ubw.3_Missense_Mutation_p.T32I|LRRC43_uc009zxn.2_5'Flank|LRRC43_uc009zxl.1_RNA	NM_001098519	NP_001091989	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43 isoform 1	217											0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		CTCTACGTCACCGCTAATCAC	0.562													T	122672375	T	T	122672375	3	4	176	1	0	0	0	0	1	0	0	0	9001	507	18	3	664	3	LRRC43	12	122672375	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	55899300	122672375	11179520	45	12543											
NBEA	26960	broad.mit.edu	37	chr13	35685025	35685025	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acaccaccatacgcagagtaGgaacagtattacagctaatg	8	10	0	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr13:35685025G>C	uc001uvb.2	+	14	2118	c.1912G>C	c.(1912-1914)GGA>CGA	p.G638R		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	638						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ACGCAGAGTAGGAACAGTATT	0.368													C	35685025	C	C	35685025	3	2	176	1	0	0	0	0	1	0	0	0	10187	1001	35	5	1962	5	NBEA	13	35685025	Missense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08		35685025	79484853	46	12544											
OR4K2	390431	broad.mit.edu	37	chr14	20344857	20344857	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccccaggtgtgtgttgctcTcgtggtggcttcctggatta	13	10	1	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr14:20344857T>C	uc001vwh.1	+	1	431	c.431T>C	c.(430-432)CTC>CCC	p.L144P		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTGTTGCTCTCGTGGTGGCT	0.463													C	20344857	C	C	20344857	3	2	176	1	0	0	0	0	1	0	0	0	11072	1551	54	4	433	4	OR4K2	14	20344857	Missense_Mutation	SNP	T	TCGA-26-5134-01A-01D-1486-08		20344857	87004683	47	12545											
PCNX	22990	broad.mit.edu	37	chr14	71540387	71540387	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttaatgctgcatttagccagCgatggctagcttgggaagtg	13	7	0	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr14:71540387C>T	uc001xmo.2	+	27	5424	c.4978C>T	c.(4978-4980)CGA>TGA	p.R1660*	PCNX_uc010are.1_Nonsense_Mutation_p.R1549*|PCNX_uc010arf.1_Nonsense_Mutation_p.R448*	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1660						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		ATTTAGCCAGCGATGGCTAGC	0.438													T	71540387	T	T	71540387	4	4	176	1	0	0	0	0	0	1	0	0	11591	760	27	1	5084	1	PCNX	14	71540387	Nonsense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	51195530	71540387	35809153	48	12546											
EML5	161436	broad.mit.edu	37	chr14	89168805	89168805	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctacctggcctgttgccacGtagtctttcaaaggatgaat	9	11	2	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr14:89168805G>A	uc001xxg.2	-	15	2409	c.2223C>T	c.(2221-2223)TAC>TAT	p.Y741Y	EML5_uc001xxh.1_Translation_Start_Site	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	741	WD 11.					cytoplasm|microtubule				ovary(3)	3						CTGTTGCCACGTAGTCTTTCA	0.368													A	89168805	A	A	89168805	2	1	176	1	0	0	0	0	0	0	0	1	5100	1140	40	1		1	EML5	14	89168805	Silent	SNP	G	TCGA-26-5134-01A-01D-1486-08	17628418	89168805	18180735	49	12547											
AQR	9716	broad.mit.edu	37	chr15	35168164	35168164	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaagagggataaaagtttctAtctccagaatctgagcagcc	10	8	3	3			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr15:35168164A>G	uc001ziv.2	-	28	3390	c.3209T>C	c.(3208-3210)ATA>ACA	p.I1070T		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	1070						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		AAAAGTTTCTATCTCCAGAAT	0.358													G	35168164	G	G	35168164	3	3	176	1	0	0	0	0	1	0	0	0	835	449	16	4	1280	4	AQR	15	35168164	Missense_Mutation	SNP	A	TCGA-26-5134-01A-01D-1486-08		35168164	67363228	50	12548			1	33		2	2	12	N	C_A	2.274115e-05
AQR	9716	broad.mit.edu	37	chr15	35168175	35168175	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaagtttctatctccagaatCtgagcagcctcttccatcaa	5	12	5	2			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr15:35168175C>T	uc001ziv.2	-	28	3379	c.3198G>A	c.(3196-3198)CAG>CAA	p.Q1066Q		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	1066						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TCTCCAGAATCTGAGCAGCCT	0.353													T	35168175	T	T	35168175	2	4	176	1	0	0	0	0	0	0	0	1	835	912	32	3		3	AQR	15	35168175	Silent	SNP	C	TCGA-26-5134-01A-01D-1486-08	11	35168175	67363217	51	12549			1	33		2	2	12	N	C_A	2.274115e-05
NOX5	79400	broad.mit.edu	37	chr15	69324094	69324094	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gcaacggggccatcaccttcGaggagctccgggacgagctg	15	13	1	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr15:69324094G>T	uc002ars.1	+	4	582	c.562G>T	c.(562-564)GAG>TAG	p.E188*	NOX5_uc002arp.1_Nonsense_Mutation_p.E170*|NOX5_uc002arq.1_Nonsense_Mutation_p.E142*|NOX5_uc010bid.1_Nonsense_Mutation_p.E153*|NOX5_uc002arr.1_Nonsense_Mutation_p.E160*|NOX5_uc010bie.1_5'UTR|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	188	Cytoplasmic (Potential).|4 (Potential).|EF-hand 4.				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						CATCACCTTCGAGGAGCTCCG	0.677													T	69324094	T	T	69324094	4	4	176	1	0	0	0	0	0	1	0	0	10559	1059	37	5	609	5	NOX5	15	69324094	Nonsense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08	34155919	69324094	33207298	52	12550											
PAPD5	64282	broad.mit.edu	37	chr16	50263117	50263117	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aaggcttccaaggtacaactCaaacaagccatggttccttg	8	11	1	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr16:50263117C>G	uc010vgo.1	+	13	2010	c.1975C>G	c.(1975-1977)CAA>GAA	p.Q659E	PAPD5_uc010cbi.2_Intron|PAPD5_uc002efz.2_Missense_Mutation_p.Q403E|PAPD5_uc002ega.2_Missense_Mutation_p.Q450E	NM_001040284	NP_001035374	Q8NDF8	PAPD5_HUMAN	PAP associated domain containing 5 isoform a	533					cell division|DNA replication|histone mRNA catabolic process|mitosis	cytoplasm|nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding				0		all_cancers(37;0.0452)		BRCA - Breast invasive adenocarcinoma(181;0.0843)|GBM - Glioblastoma multiforme(240;0.231)		AGGTACAACTCAAACAAGCCA	0.433													G	50263117	G	G	50263117	3	3	176	1	0	0	0	0	1	0	0	0	11425	827	29	5	2025	5	PAPD5	16	50263117	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08		50263117	40091636	53	12551											
INPP5K	51763	broad.mit.edu	37	chr17	1419767	1419767	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cacctgagcctcctgcctttCggcccgctcagcttccgcga	9	19	1	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr17:1419767C>G	uc002fsr.2	-	1	416	c.27G>C	c.(25-27)CCG>CCC	p.P9P	INPP5K_uc002fss.2_5'UTR|INPP5K_uc002fsq.2_5'UTR|INPP5K_uc010cjr.2_5'UTR|INPP5K_uc010vql.1_5'UTR|INPP5K_uc010vqm.1_Silent_p.P9P|INPP5K_uc010cjs.2_Silent_p.P9P	NM_016532	NP_057616	Q9BT40	INP5K_HUMAN	inositol polyphosphate-5-phosphatase K isoform	9					actin cytoskeleton organization	cytosol|endoplasmic reticulum|membrane fraction|neuron projection|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol bisphosphate phosphatase activity|inositol bisphosphate phosphatase activity|inositol trisphosphate phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|lipid phosphatase activity|protein binding				0						TCCTGCCTTTCGGCCCGCTCA	0.756													G	1419767	G	G	1419767	2	3	176	1	0	0	0	0	0	0	0	1	7760	871	31	5		5	INPP5K	17	1419767	Silent	SNP	C	TCGA-26-5134-01A-01D-1486-08		1419767	79775443	54	12552											
PHF12	57649	broad.mit.edu	37	chr17	27233967	27233967	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atacagcacattgtccaccgTtgtcccatgctcactgtagt	7	13	1	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr17:27233967T>C	uc002hdg.1	-	14	3117	c.2587A>G	c.(2587-2589)ACG>GCG	p.T863A	PHF12_uc010wbb.1_Missense_Mutation_p.T845A	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	863	FHA.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TTGTCCACCGTTGTCCCATGC	0.507													C	27233967	C	C	27233967	3	2	176	1	0	0	0	0	1	0	0	0	11823	1725	60	4	435	4	PHF12	17	27233967	Missense_Mutation	SNP	T	TCGA-26-5134-01A-01D-1486-08	25814200	27233967	53961243	55	12553											
DSG3	1830	broad.mit.edu	37	chr18	29052357	29052357	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggaacaattcatcagtggGgaattgaaggagcccatcct	11	8	2	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr18:29052357G>A	uc002kws.2	+	13	2117	c.2008G>A	c.(2008-2010)GGA>AGA	p.G670R	DSG3_uc002kwt.2_5'Flank	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	670	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TCATCAGTGGGGAATTGAAGG	0.428													A	29052357	A	A	29052357	3	1	176	1	0	0	0	0	1	0	0	0	4778	1233	43	3	2058	3	DSG3	18	29052357	Missense_Mutation	SNP	G	TCGA-26-5134-01A-01D-1486-08		29052357	49024891	56	12554											
S1PR4	8698	broad.mit.edu	37	chr19	3179828	3179828	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggccgtcgaggctcactcCggagcttccaccaccgacag	12	17	1	0	rs147906636	byFrequency	TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr19:3179828C>T	uc002lxg.2	+	1	1063	c.1038C>T	c.(1036-1038)TCC>TCT	p.S346S		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	346	Cytoplasmic (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						AGGCTCACTCCGGAGCTTCCA	0.687													T	3179828	T	T	3179828	2	4	176	1	0	0	0	0	0	0	0	1	13796	639	23	2		2	S1PR4	19	3179828	Silent	SNP	C	TCGA-26-5134-01A-01D-1486-08		3179828	55949155	57	12555											
TYK2	7297	broad.mit.edu	37	chr19	10463654	10463654	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcggtagtactcgtggccttCgggcacggccttggctaggc	16	12	0	0			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr19:10463654C>T	uc002moc.3	-	22	3526	c.3148G>A	c.(3148-3150)GAA>AAA	p.E1050K	TYK2_uc010dxe.2_Missense_Mutation_p.E865K	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	1050	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TCGTGGCCTTCGGGCACGGCC	0.652													T	10463654	T	T	10463654	3	4	176	1	0	0	0	0	1	0	0	0	16807	893	31	2	431	2	TYK2	19	10463654	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	7283826	10463654	48665329	58	12556											
ZNF540	163255	broad.mit.edu	37	chr19	38103690	38103690	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgtacgatgtgggaagacCtttagatttggtttctacct	11	6	1	2			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr19:38103690C>T	uc002ogq.2	+	5	1841	c.1509C>T	c.(1507-1509)ACC>ACT	p.T503T	ZNF540_uc002ogu.2_Silent_p.T503T|ZNF540_uc010efq.2_Silent_p.T471T	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	503	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTGGGAAGACCTTTAGATTTG	0.393													T	38103690	T	T	38103690	2	4	176	1	0	0	0	0	0	0	0	1	17972	668	24	3		3	ZNF540	19	38103690	Silent	SNP	C	TCGA-26-5134-01A-01D-1486-08	27640036	38103690	21025293	59	12557											
CD33	945	broad.mit.edu	37	chr19	51728575	51728575	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctgcactttcttccatcccAtaccctactacgacaagaac	3	17	1	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr19:51728575A>T	uc002pwa.2	+	2	179	c.139A>T	c.(139-141)ATA>TTA	p.I47L	CD33_uc010eos.1_Missense_Mutation_p.I47L|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	47	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CTTCCATCCCATACCCTACTA	0.532													T	51728575	T	T	51728575	3	4	176	1	0	0	0	0	1	0	0	0	3005	217	8	5	145	5	CD33	19	51728575	Missense_Mutation	SNP	A	TCGA-26-5134-01A-01D-1486-08	13624885	51728575	7400408	60	12558											
FAM113A	64773	broad.mit.edu	37	chr20	2819125	2819125	+	Splice_Site	DEL	C	-	-													gagcctgccaggggctggagCtaagtgagaaagtgcagcct							TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr20:2819125delC	uc002wgz.1	-	6	1092	c.595_splice	c.e6-1	p.L199_splice	FAM113A_uc002whb.1_Intron|FAM113A_uc002wha.1_Intron|FAM113A_uc010zqa.1_Splice_Site_p.L46_splice|FAM113A_uc002whc.1_Splice_Site_p.L148_splice|VPS16_uc002whe.2_5'Flank|VPS16_uc002whf.2_5'Flank|VPS16_uc002whd.2_5'Flank	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773								hydrolase activity|protein binding			ovary(2)	2						GGGGCTGGAGCTAAGTGAGAA	0.572													-	2819125	-	-	2819125	8	5	176	1	0	1	0	1	0	0	1	0	5401	811	28	0	782	0	FAM113A	20	2819125	Splice_Site	DEL	C	TCGA-26-5134-01A-01D-1486-08		2819125	60206395	61	12559											
ISM1	140862	broad.mit.edu	37	chr20	13260546	13260546	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caaagatcagccagaatatgGtgagtttaccacctagtaat	8	8	1	3			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr20:13260546G>T	uc010gce.1	+	3	649	c.643_splice	c.e3+1	p.D215_splice	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor							extracellular region					0						CCAGAATATGGTGAGTTTACC	0.498													T	13260546	T	T	13260546	5	4	176	1	0	0	0	0	0	0	1	0	7860	1275	44	5	654	5	ISM1	20	13260546	Splice_Site	SNP	G	TCGA-26-5134-01A-01D-1486-08	10441421	13260546	49764974	62	12560											
CSTF1	1477	broad.mit.edu	37	chr20	54974411	54974411	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgaacactggtcagatacaCgggtatgtgagacgttgatg	13	7	1	3			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr20:54974411C>T	uc002xxl.1	+	5	1234	c.1034C>T	c.(1033-1035)ACG>ATG	p.T345M	CSTF1_uc002xxm.1_Missense_Mutation_p.T345M|CSTF1_uc002xxn.1_Missense_Mutation_p.T345M|CSTF1_uc002xxo.1_Missense_Mutation_p.T288M	NM_001033521	NP_001028693	Q05048	CSTF1_HUMAN	cleavage stimulation factor subunit 1	345					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(1)	1			Colorectal(105;0.202)			GTCAGATACACGGGTATGTGA	0.244													T	54974411	T	T	54974411	3	4	176	1	0	0	0	0	1	0	0	0	3983	536	19	1	1048	1	CSTF1	20	54974411	Missense_Mutation	SNP	C	TCGA-26-5134-01A-01D-1486-08	41713865	54974411	8051109	63	12561											
CXADR	1525	broad.mit.edu	37	chr21	18933791	18933791	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaggaagttcatcacgataTcaggtaattaagtgagacag	10	5	3	1			TCGA-26-5134-01A-01D-1486-08	TCGA-26-5134-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	11956d98-4ba5-486f-ae79-05aacebe0631	7a2da706-da57-4677-8c2f-ef27469a04de	g.chr21:18933791T>C	uc002yki.2	+	6	948	c.830T>C	c.(829-831)ATC>ACC	p.I277T	CXADR_uc002ykh.1_Intron|CXADR_uc010gld.1_Intron|CXADR_uc010gle.1_Intron|CXADR_uc002ykj.1_Missense_Mutation_p.I250T	NM_001338	NP_001329	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	277	Cytoplasmic (Potential).				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			ovary(1)	1				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		CATCACGATATCAGGTAATTA	0.363													C	18933791	C	C	18933791	3	2	176	1	0	0	0	0	1	0	0	0	4076	1435	50	4	852	4	CXADR	21	18933791	Missense_Mutation	SNP	T	TCGA-26-5134-01A-01D-1486-08		18933791	29196104	64	12562											
HCRTR1	3061	broad.mit.edu	37	chr1	32084853	32084853	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccctggcagcagagagccGtcccctgtgcctccagacta	10	18	0	2	rs142288232		TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:32084853G>A	uc009vtx.2	+	3	445	c.60G>A	c.(58-60)CCG>CCA	p.P20P	HCRTR1_uc001btb.2_Intron|HCRTR1_uc001btc.3_5'UTR|HCRTR1_uc001btd.2_Silent_p.P20P|HCRTR1_uc010ogl.1_Silent_p.P20P	NM_001525	NP_001516	O43613	OX1R_HUMAN	orexin receptor 1	20	Extracellular (Potential).				feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				ovary(1)	1		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		GCAGAGAGCCGTCCCCTGTGC	0.607													A	32084853	A	A	32084853	2	1	177	1	0	0	0	0	0	0	0	1	7001	1132	40	1		1	HCRTR1	1	32084853	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08		32084853	217165768	1	12563											
MSH4	4438	broad.mit.edu	37	chr1	76269590	76269590	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagctggacaccacaagtggGatattcaggtaaaataagtg	12	6	1	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:76269590G>A	uc001dhd.1	+	2	460	c.419G>A	c.(418-420)GGA>GAA	p.G140E		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	140					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						CCACAAGTGGGATATTCAGGT	0.313								MMR					A	76269590	A	A	76269590	3	1	177	1	0	0	0	0	1	0	0	0	9872	1174	41	3	425	3	MSH4	1	76269590	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	44184737	76269590	172981031	2	12564											
KCNA10	3744	broad.mit.edu	37	chr1	111061339	111061339	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctgtggcatagcctggctctTcttggatttcatctgaatta	9	9	4	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:111061339T>A	uc001dzt.1	-	1	459	c.71A>T	c.(70-72)GAA>GTA	p.E24V		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	24						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GCCTGGCTCTTCTTGGATTTC	0.522													A	111061339	A	A	111061339	3	1	177	1	0	0	0	0	1	0	0	0	8002	1783	62	5	1468	5	KCNA10	1	111061339	Missense_Mutation	SNP	T	TCGA-26-5135-01A-01D-1486-08	34791749	111061339	138189282	3	12565											
TRIM33	51592	broad.mit.edu	37	chr1	114969900	114969900	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accgtgctttcaaaatatgaCgcaactggaaagtaatctta	7	8	2	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:114969900C>T	uc001eew.2	-	8	1403	c.1319G>A	c.(1318-1320)CGT>CAT	p.R440H	TRIM33_uc010owr.1_Missense_Mutation_p.R48H|TRIM33_uc010ows.1_Missense_Mutation_p.R48H|TRIM33_uc001eex.2_Missense_Mutation_p.R440H	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	440					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAAATATGACGCAACTGGAA	0.353			T	RET	papillary thyroid								T	114969900	T	T	114969900	3	4	177	1	0	0	0	0	1	0	0	0	16504	536	19	1	2116	1	TRIM33	1	114969900	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	3908561	114969900	134280721	4	12566											
CRTC2	200186	broad.mit.edu	37	chr1	153927550	153927550	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtctactcacctggaactcGgccaggccagagccaatctg	11	14	3	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:153927550G>A	uc010ped.1	-	2	316	c.246C>T	c.(244-246)GCC>GCT	p.A82A	CRTC2_uc001fde.3_5'Flank|CRTC2_uc001fdf.3_5'Flank	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	82					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCTGGAACTCGGCCAGGCCAG	0.547													A	153927550	A	A	153927550	2	1	177	1	0	0	0	0	0	0	0	1	3900	1103	39	2		2	CRTC2	1	153927550	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08	38957650	153927550	95323071	5	12567											
GON4L	54856	broad.mit.edu	37	chr1	155791284	155791284	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaacattggcatatcttccGtctcactgatggctgctttc	7	12	2	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:155791284G>A	uc001flz.2	-	5	1041	c.944C>T	c.(943-945)ACG>ATG	p.T315M	GON4L_uc001fly.1_Missense_Mutation_p.T315M|GON4L_uc009wrh.1_Missense_Mutation_p.T315M|GON4L_uc001fma.1_Missense_Mutation_p.T315M|GON4L_uc001fmc.2_Missense_Mutation_p.T315M|GON4L_uc001fmd.3_Missense_Mutation_p.T315M|GON4L_uc009wri.2_Translation_Start_Site|GON4L_uc001fme.2_Missense_Mutation_p.T143M|GON4L_uc001fmf.2_Missense_Mutation_p.T9M	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	315					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CATATCTTCCGTCTCACTGAT	0.398													A	155791284	A	A	155791284	3	1	177	1	0	0	0	0	1	0	0	0	6572	1145	40	1	6007	1	GON4L	1	155791284	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	1863734	155791284	93459337	6	12568											
SPTA1	6708	broad.mit.edu	37	chr1	158609712	158609712	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtgttgaacctctgttgaCgactggcctcattgagcttc	10	10	2	3			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:158609712C>T	uc001fst.1	-	34	5022	c.4823G>A	c.(4822-4824)CGT>CAT	p.R1608H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1608	Spectrin 16.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCTCTGTTGACGACTGGCCTC	0.463													T	158609712	T	T	158609712	3	4	177	1	0	0	0	0	1	0	0	0	15115	536	19	1	2512	1	SPTA1	1	158609712	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	2818428	158609712	90640909	7	12569											
DUSP27	92235	broad.mit.edu	37	chr1	167096396	167096396	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgctgatggggacacgacGtcagtactgagcacccagag	14	11	1	3			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:167096396G>A	uc001geb.1	+	5	2028	c.2028G>A	c.(2026-2028)ACG>ACA	p.T676T		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	676					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GGGACACGACGTCAGTACTGA	0.637													A	167096396	A	A	167096396	2	1	177	1	0	0	0	0	0	0	0	1	4824	1132	40	1		1	DUSP27	1	167096396	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08	8486684	167096396	82154225	8	12570											
C4BPB	725	broad.mit.edu	37	chr1	207263727	207263727	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggtggaaggacagattctgGggacttacgtttgtatcaag	14	5	2	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:207263727G>T	uc001hfj.2	+	3	263	c.133G>T	c.(133-135)GGG>TGG	p.G45W	C4BPB_uc001hfi.2_Missense_Mutation_p.G44W|C4BPB_uc001hfk.2_Missense_Mutation_p.G44W|C4BPB_uc001hfl.2_Missense_Mutation_p.G45W|C4BPB_uc009xcd.2_Missense_Mutation_p.G35W|C4BPB_uc001hfm.2_Missense_Mutation_p.G45W|C4BPB_uc010pse.1_Missense_Mutation_p.G35W	NM_001017365	NP_001017365	P20851	C4BPB_HUMAN	complement component 4 binding protein, beta	45	Sushi 1.				blood coagulation|complement activation, classical pathway|innate immune response	extracellular region				ovary(1)	1						ACAGATTCTGGGGACTTACGT	0.473													T	207263727	T	T	207263727	3	4	177	1	0	0	0	0	1	0	0	0	2250	1232	43	5	139	5	C4BPB	1	207263727	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	40167331	207263727	41986894	9	12571											
OR2L13	284521	broad.mit.edu	37	chr1	248263039	248263039	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacctccatggcctacgaccGttatttggccatctgccact	8	15	1	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr1:248263039G>A	uc001ids.2	+	3	699	c.362G>A	c.(361-363)CGT>CAT	p.R121H		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			GCCTACGACCGTTATTTGGCC	0.498													A	248263039	A	A	248263039	3	1	177	1	0	0	0	0	1	0	0	0	11006	1145	40	1	364	1	OR2L13	1	248263039	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	40999312	248263039	987582	10	12572											
C2orf70	339778	broad.mit.edu	37	chr2	26798883	26798883	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catggagaagagccacactcCcttcagccaaggcggccatt	10	14	1	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr2:26798883C>T	uc010eyn.2	+	2	188	c.188C>T	c.(187-189)CCC>CTC	p.P63L		NM_001105519	NP_001098989	A6NJV1	CB070_HUMAN	hypothetical protein LOC339778	63										skin(1)	1						AGCCACACTCCCTTCAGCCAA	0.637													T	26798883	T	T	26798883	3	4	177	1	0	0	0	0	1	0	0	0	2190	623	22	3	194	3	C2orf70	2	26798883	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08		26798883	216400490	11	12573											
VAMP5	10791	broad.mit.edu	37	chr2	85818867	85818867	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcaggaatagagttggagcGgtgccagcagcaggcgaacg	18	8	0	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr2:85818867G>A	uc002spu.1	+	2	106	c.23G>A	c.(22-24)CGG>CAG	p.R8Q		NM_006634	NP_006625	O95183	VAMP5_HUMAN	vesicle-associated membrane protein 5	8	v-SNARE coiled-coil homology.|Cytoplasmic (Potential).				cell differentiation|vesicle-mediated transport	endomembrane system					0						GAGTTGGAGCGGTGCCAGCAG	0.602													A	85818867	A	A	85818867	3	1	177	1	0	0	0	0	1	0	0	0	17113	1116	39	2	29	2	VAMP5	2	85818867	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	59019984	85818867	157380506	12	12574											
SEMA4C	54910	broad.mit.edu	37	chr2	97533539	97533539	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagacactgtcttacgcgGcacaaggttccaccacacct	8	14	1	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr2:97533539G>A	uc002sxh.3	-	2	245	c.85C>T	c.(85-87)CCG>TCG	p.P29S	SEMA4C_uc002sxg.3_5'Flank	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	29	Extracellular (Potential).				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						GTCTTACGCGGCACAAGGTTC	0.642													A	97533539	A	A	97533539	3	1	177	1	0	0	0	0	1	0	0	0	14033	1203	42	3	2472	3	SEMA4C	2	97533539	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	11714672	97533539	145665834	13	12575											
FYCO1	79443	broad.mit.edu	37	chr3	45996750	45996750	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctctactcactgttcagccGcatttgggtcgagagaatca	9	12	4	1	rs140583635		TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr3:45996750G>A	uc003cpb.3	-	14	4141	c.3935C>T	c.(3934-3936)GCG>GTG	p.A1312V	FYCO1_uc011bal.1_Missense_Mutation_p.A1312V	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	1312					transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CTGTTCAGCCGCATTTGGGTC	0.498													A	45996750	A	A	45996750	3	1	177	1	0	0	0	0	1	0	0	0	6125	1087	38	1	521	1	FYCO1	3	45996750	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08		45996750	152025680	14	12576											
PFKFB4	5210	broad.mit.edu	37	chr3	48563038	48563038	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accggtacttgtcctggtccCgcagggcgaactccagtgga	13	13	0	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr3:48563038C>T	uc003ctv.2	-	10	1069	c.1052G>A	c.(1051-1053)CGG>CAG	p.R351Q	PFKFB4_uc003ctw.2_Missense_Mutation_p.R160Q|PFKFB4_uc010hkc.2_Intron|PFKFB4_uc003ctx.2_Missense_Mutation_p.R308Q|PFKFB4_uc010hkb.2_Missense_Mutation_p.R344Q|PFKFB4_uc011bbm.1_Missense_Mutation_p.R340Q|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	351	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		GTCCTGGTCCCGCAGGGCGAA	0.562													T	48563038	T	T	48563038	3	4	177	1	0	0	0	0	1	0	0	0	11763	652	23	2	377	2	PFKFB4	3	48563038	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	2566288	48563038	149459392	15	12577											
NISCH	11188	broad.mit.edu	37	chr3	52521957	52521957	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctttgcaccccagcacatgGccatgctgtgtagccccatc	9	16	0	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr3:52521957G>A	uc011beg.1	+	17	2521	c.2449G>A	c.(2449-2451)GCC>ACC	p.A817T	NISCH_uc003ded.3_Missense_Mutation_p.A817T|NISCH_uc003dee.3_Missense_Mutation_p.A306T|NISCH_uc003deg.1_RNA	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	817	Interaction with LIMK (By similarity).|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CCAGCACATGGCCATGCTGTG	0.622													A	52521957	A	A	52521957	3	1	177	1	0	0	0	0	1	0	0	0	10432	1203	42	3	2511	3	NISCH	3	52521957	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	3958919	52521957	145500473	16	12578											
ADCY5	111	broad.mit.edu	37	chr3	123046533	123046533	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttgaggtaggcgttgcgctCgcccccacagcctggctcca	12	16	0	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr3:123046533C>T	uc003egh.1	-	7	1879	c.1879G>A	c.(1879-1881)GAG>AAG	p.E627K	ADCY5_uc003egg.1_Missense_Mutation_p.E260K|ADCY5_uc003egi.1_Missense_Mutation_p.E186K	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	627	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GCGTTGCGCTCGCCCCCACAG	0.642													T	123046533	T	T	123046533	3	4	177	1	0	0	0	0	1	0	0	0	297	893	31	2	1966	2	ADCY5	3	123046533	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	70524576	123046533	74975897	17	12579											
RBP2	5948	broad.mit.edu	37	chr3	139195249	139195249	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccagggccttcatgtagcccTcaaagttttcattactctcc	6	14	4	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr3:139195249T>C	uc003eth.2	-	1	104	c.53A>G	c.(52-54)GAG>GGG	p.E18G		NM_004164	NP_004155	P50120	RET2_HUMAN	retinol binding protein 2, cellular	18					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			skin(1)	1					Vitamin A(DB00162)	CATGTAGCCCTCAAAGTTTTC	0.542													C	139195249	C	C	139195249	3	2	177	1	0	0	0	0	1	0	0	0	13156	1551	54	4	367	4	RBP2	3	139195249	Missense_Mutation	SNP	T	TCGA-26-5135-01A-01D-1486-08	16148716	139195249	58827181	18	12580											
PSMD2	5708	broad.mit.edu	37	chr3	184021749	184021749	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgtagtcaggagctcttctTgcctgtggcatagtgaactc	11	9	3	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr3:184021749T>C	uc003fnn.1	+	11	1371	c.1338T>C	c.(1336-1338)CTT>CTC	p.L446L	PSMD2_uc011brj.1_Silent_p.L287L|PSMD2_uc011brk.1_Silent_p.L316L	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	446	PC 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GAGCTCTTCTTGCCTGTGGCA	0.512													C	184021749	C	C	184021749	2	2	177	1	0	0	0	0	0	0	0	1	12698	1799	63	4		4	PSMD2	3	184021749	Silent	SNP	T	TCGA-26-5135-01A-01D-1486-08	44826500	184021749	14000681	19	12581											
LRRC15	131578	broad.mit.edu	37	chr3	194080518	194080518	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagggattgtcatacagccGcagctcacacagtttcccca	8	15	2	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr3:194080518G>A	uc003ftu.2	-	2	1341	c.1255C>T	c.(1255-1257)CGG>TGG	p.R419W	LRRC15_uc003ftt.2_Missense_Mutation_p.R425W	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	419	Extracellular (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TCATACAGCCGCAGCTCACAC	0.577													A	194080518	A	A	194080518	3	1	177	1	0	0	0	0	1	0	0	0	8970	1086	38	1	494	1	LRRC15	3	194080518	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	10058769	194080518	3941912	20	12582											
ADD1	118	broad.mit.edu	37	chr4	2930135	2930135	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccctcagctgtcgaggaggGggccgccgcggaccctggca	16	16	1	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr4:2930135G>A	uc003gfr.2	+	15	2287	c.2099G>A	c.(2098-2100)GGG>GAG	p.G700E	ADD1_uc003gfn.2_RNA|ADD1_uc003gfo.2_3'UTR|ADD1_uc003gfp.2_3'UTR|ADD1_uc003gfq.2_Missense_Mutation_p.G731E|ADD1_uc003gfs.2_3'UTR	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	700					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GTCGAGGAGGGGGCCGCCGCG	0.662													A	2930135	A	A	2930135	3	1	177	1	0	0	0	0	1	0	0	0	304	1232	43	3	2284	3	ADD1	4	2930135	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08		2930135	188224141	21	12583											
RXFP1	59350	broad.mit.edu	37	chr4	159538309	159538309	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgaataacgtcctcacccGtttacctgataaacctctct	5	13	2	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr4:159538309G>A	uc003ipz.2	+	9	789	c.707G>A	c.(706-708)CGT>CAT	p.R236H	RXFP1_uc010iqj.1_Missense_Mutation_p.R65H|RXFP1_uc011cja.1_Missense_Mutation_p.R155H|RXFP1_uc010iqo.2_Missense_Mutation_p.R236H|RXFP1_uc011cjb.1_Missense_Mutation_p.R182H|RXFP1_uc010iqk.2_Missense_Mutation_p.R104H|RXFP1_uc011cjc.1_Missense_Mutation_p.R155H|RXFP1_uc011cjd.1_Missense_Mutation_p.R155H|RXFP1_uc010iql.2_Missense_Mutation_p.R104H|RXFP1_uc011cje.1_Missense_Mutation_p.R263H|RXFP1_uc010iqm.2_Missense_Mutation_p.R203H|RXFP1_uc011cjf.1_Missense_Mutation_p.R106H|RXFP1_uc010iqn.2_Missense_Mutation_p.R182H	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	236	Extracellular (Potential).|LRR 4.					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		GTCCTCACCCGTTTACCTGAT	0.363													A	159538309	A	A	159538309	3	1	177	1	0	0	0	0	1	0	0	0	13759	1145	40	1	741	1	RXFP1	4	159538309	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	156608174	159538309	31615967	22	12584											
ODZ3	55714	broad.mit.edu	37	chr4	183713542	183713542	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccacaccatgcagaccatccGatccattggctactaccgca	6	17	0	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr4:183713542G>A	uc003ivd.1	+	25	5754	c.5717G>A	c.(5716-5718)CGA>CAA	p.R1906Q		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1906	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CAGACCATCCGATCCATTGGC	0.542													A	183713542	A	A	183713542	3	1	177	1	0	0	0	0	1	0	0	0	10836	1058	37	2	5815	2	ODZ3	4	183713542	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	24175233	183713542	7440734	23	12585											
SLC6A19	340024	broad.mit.edu	37	chr5	1216784	1216784	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccgcgccacacagcgctaCgacgactgcttcagcacgtg	10	16	1	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr5:1216784C>T	uc003jbw.3	+	7	1055	c.999C>T	c.(997-999)TAC>TAT	p.Y333Y		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	333	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CACAGCGCTACGACGACTGCT	0.617													T	1216784	T	T	1216784	2	4	177	1	0	0	0	0	0	0	0	1	14682	547	19	1		1	SLC6A19	5	1216784	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08		1216784	179698476	24	12586											
UGT3A1	133688	broad.mit.edu	37	chr5	35955903	35955903	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccatgggcacaccatgaCggatggcctccattacgctg	10	15	0	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr5:35955903C>T	uc003jjv.1	-	6	1296	c.1139G>A	c.(1138-1140)CGT>CAT	p.R380H	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.R380H|UGT3A1_uc011cor.1_Missense_Mutation_p.R346H	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	380	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CACACCATGACGGATGGCCTC	0.493													T	35955903	T	T	35955903	3	4	177	1	0	0	0	0	1	0	0	0	16960	536	19	1	440	1	UGT3A1	5	35955903	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	34739119	35955903	144959357	25	12587											
HCN1	348980	broad.mit.edu	37	chr5	45262136	45262136	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtgctggagggactcctcGgttcggggggatggctcccg	20	10	0	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr5:45262136G>A	uc003jok.2	-	8	2585	c.2560C>T	c.(2560-2562)CGA>TGA	p.R854*		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	854	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GGGACTCCTCGGTTCGGGGGG	0.632													A	45262136	A	A	45262136	4	1	177	1	0	0	0	0	0	1	0	0	6996	1124	39	2	116	2	HCN1	5	45262136	Nonsense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	9306233	45262136	135653124	26	12588											
HCN1	348980	broad.mit.edu	37	chr5	45353296	45353296	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtaatcatgtatcttctgaCgcatatcagctggtaactta	7	8	4	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr5:45353296C>T	uc003jok.2	-	5	1308	c.1283G>A	c.(1282-1284)CGT>CAT	p.R428H		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	428	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TATCTTCTGACGCATATCAGC	0.338													T	45353296	T	T	45353296	3	4	177	1	0	0	0	0	1	0	0	0	6996	536	19	1	1405	1	HCN1	5	45353296	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	91160	45353296	135561964	27	12589											
PTCD2	79810	broad.mit.edu	37	chr5	71634538	71634538	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tccaggagagcatcctgtttCgctgtggcattagctctgaa	11	10	1	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr5:71634538C>T	uc003kcb.2	+	7	739	c.729C>T	c.(727-729)TTC>TTT	p.F243F	PTCD2_uc011csf.1_Silent_p.F53F|PTCD2_uc003kcc.2_Silent_p.F91F|PTCD2_uc011csg.1_Silent_p.F71F|PTCD2_uc011csh.1_Silent_p.F134F|PTCD2_uc003kcd.2_RNA	NM_024754	NP_079030	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	243											0		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		CATCCTGTTTCGCTGTGGCAT	0.423													T	71634538	T	T	71634538	2	4	177	1	0	0	0	0	0	0	0	1	12728	883	31	2		2	PTCD2	5	71634538	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08	26281242	71634538	109280722	28	12590											
FCHO2	115548	broad.mit.edu	37	chr5	72370577	72370577	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtatattctaggtgtgtcaCggggtcccagccctgtcagc	12	11	3	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr5:72370577C>T	uc003kcl.2	+	20	1704	c.1588C>T	c.(1588-1590)CGG>TGG	p.R530W	FCHO2_uc011csl.1_Missense_Mutation_p.R497W|FCHO2_uc010izb.2_Translation_Start_Site|FCHO2_uc011csn.1_Translation_Start_Site	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2 isoform a	530										ovary(1)	1		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		AGGTGTGTCACGGGGTCCCAG	0.403													T	72370577	T	T	72370577	3	4	177	1	0	0	0	0	1	0	0	0	5788	527	19	1	1666	1	FCHO2	5	72370577	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	736039	72370577	108544683	29	12591											
ARRDC3	57561	broad.mit.edu	37	chr5	90672545	90672545	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcggctttcacccaatagcGcacactgccatgtcggcctt	8	15	1	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr5:90672545G>A	uc003kjz.2	-	3	643	c.403C>T	c.(403-405)CGC>TGC	p.R135C		NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	135					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		ACCCAATAGCGCACACTGCCA	0.398													A	90672545	A	A	90672545	3	1	177	1	0	0	0	0	1	0	0	0	984	1087	38	1	865	1	ARRDC3	5	90672545	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	18301968	90672545	90242715	30	12592											
SLIT3	6586	broad.mit.edu	37	chr5	168112721	168112721	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgttggcctggggtcggaCcttggcggaggccagttcca	17	10	0	0	rs143177032		TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr5:168112721C>T	uc003mab.2	-	31	3946	c.3526G>A	c.(3526-3528)GTC>ATC	p.V1176I	SLIT3_uc010jjg.2_Missense_Mutation_p.V1183I	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1176	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGGGTCGGACCTTGGCGGAG	0.607													T	168112721	T	T	168112721	3	4	177	1	0	0	0	0	1	0	0	0	14741	507	18	3	1069	3	SLIT3	5	168112721	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	77440176	168112721	12802539	31	12593											
OR12D2	26529	broad.mit.edu	37	chr6	29364964	29364964	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcactccgtaatgacttctcGcttgaacttctgtggttcca	8	12	2	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr6:29364964G>A	uc003nmf.3	+	1	549	c.488G>A	c.(487-489)CGC>CAC	p.R163H		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGACTTCTCGCTTGAACTTC	0.468													A	29364964	A	A	29364964	3	1	177	1	0	0	0	0	1	0	0	0	10931	1087	38	1	490	1	OR12D2	6	29364964	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08		29364964	141750103	32	12594											
HLA-G	3135	broad.mit.edu	37	chr6	29797340	29797340	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acccaggacgtggagctcgtGgagaccaggcctgcagggga	17	11	0	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr6:29797340G>C	uc003nnw.2	+	5	943	c.765G>C	c.(763-765)GTG>GTC	p.V255V	HLA-G_uc011dmb.1_Silent_p.V227V|HLA-G_uc003raj.3_Silent_p.V260V|HLA-G_uc003nnz.3_Silent_p.V163V|HLA-G_uc010jrn.2_Intron|HLA-G_uc003nny.3_RNA|HLA-G_uc003ran.1_5'Flank	NM_002127	NP_002118	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	255	Extracellular (Potential).|Ig-like C1-type.|Alpha-3.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4						TGGAGCTCGTGGAGACCAGGC	0.632													C	29797340	C	C	29797340	2	2	177	1	0	0	0	0	0	0	0	1	7212	1335	47	5		5	HLA-G	6	29797340	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08	432376	29797340	141317727	33	12595											
SKIV2L	6499	broad.mit.edu	37	chr6	31936703	31936703	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactgtgaagctggcagggcGggtggcttgtgccatgagca	17	9	0	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr6:31936703G>A	uc003nyn.1	+	26	3625	c.3236G>A	c.(3235-3237)CGG>CAG	p.R1079Q	SKIV2L_uc011dou.1_Missense_Mutation_p.R921Q|SKIV2L_uc011dov.1_Missense_Mutation_p.R886Q|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	1079						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CTGGCAGGGCGGGTGGCTTGT	0.592													A	31936703	A	A	31936703	3	1	177	1	0	0	0	0	1	0	0	0	14359	1116	39	2	3338	2	SKIV2L	6	31936703	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	2139363	31936703	139178364	34	12596											
SFRS3	6428	broad.mit.edu	37	chr6	36564707	36564707	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgttgaatttgaagatccCcgagatgcagctgatgcagt	11	7	0	5			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr6:36564707C>T	uc003omj.2	+	2	339	c.168C>T	c.(166-168)CCC>CCT	p.P56P	SFRS3_uc003omk.2_RNA|SFRS3_uc011dtp.1_Silent_p.P56P	NM_003017	NP_003008	P84103	SRSF3_HUMAN	splicing factor, arginine/serine-rich 3	56	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TTGAAGATCCCCGAGATGCAG	0.433			T	BCL6	follicular lymphoma								T	36564707	T	T	36564707	2	4	177	1	0	0	0	0	0	0	0	1	14178	610	22	3		3	SFRS3	6	36564707	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08	4628004	36564707	134550360	35	12597											
HMGCLL1	54511	broad.mit.edu	37	chr6	55360237	55360237	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagggccgtaaggatatTtgctaaggcttgtccgtatg	13	7	0	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr6:55360237T>C	uc003pcn.2	-	8	1024	c.865A>G	c.(865-867)AAT>GAT	p.N289D	HMGCLL1_uc003pco.2_Missense_Mutation_p.N259D|HMGCLL1_uc010jzx.2_Missense_Mutation_p.N160D|HMGCLL1_uc011dxc.1_Missense_Mutation_p.N227D|HMGCLL1_uc011dxd.1_Missense_Mutation_p.N156D|HMGCLL1_uc011dxe.1_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	289							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			GTAAGGATATTTGCTAAGGCT	0.398													C	55360237	C	C	55360237	3	2	177	1	0	0	0	0	1	0	0	0	7230	1841	64	4	259	4	HMGCLL1	6	55360237	Missense_Mutation	SNP	T	TCGA-26-5135-01A-01D-1486-08	18795530	55360237	115754830	36	12598											
TIAM2	26230	broad.mit.edu	37	chr6	155504465	155504465	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gccctgttttctgagaagagCgtcggactcactctgattgc	11	11	3	3			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr6:155504465C>G	uc003qqb.2	+	16	4168	c.2895C>G	c.(2893-2895)AGC>AGG	p.S965R	TIAM2_uc003qqe.2_Missense_Mutation_p.S965R|TIAM2_uc010kjj.2_Missense_Mutation_p.S498R|TIAM2_uc003qqf.2_Missense_Mutation_p.S341R|TIAM2_uc011efl.1_Missense_Mutation_p.S301R|TIAM2_uc003qqg.2_Missense_Mutation_p.S277R	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	965	PDZ.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CTGAGAAGAGCGTCGGACTCA	0.527													G	155504465	G	G	155504465	3	3	177	1	0	0	0	0	1	0	0	0	15888	767	27	5	2937	5	TIAM2	6	155504465	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	100144228	155504465	15610602	37	12599											
TMEM195	392636	broad.mit.edu	37	chr7	15425167	15425167	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagatgaagatgatgagaaGggaacttctttgccggtgac	14	5	1	6			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr7:15425167G>A	uc003stb.1	-	10	1148	c.978C>T	c.(976-978)CCC>CCT	p.P326P		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	326					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						ATGATGAGAAGGGAACTTCTT	0.368													A	15425167	A	A	15425167	2	1	177	1	0	0	0	0	0	0	0	1	16114	987	35	3		3	TMEM195	7	15425167	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08		15425167	143713496	38	12600											
PIK3CG	5294	broad.mit.edu	37	chr7	106508579	106508579	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggcggaggtggccagccgCgaccccaagctctacgccat	13	15	1	0	rs145944814		TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr7:106508579C>T	uc003vdv.3	+	2	658	c.573C>T	c.(571-573)CGC>CGT	p.R191R	PIK3CG_uc003vdu.2_Silent_p.R191R|PIK3CG_uc003vdw.2_Silent_p.R191R	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	191					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TGGCCAGCCGCGACCCCAAGC	0.612													T	106508579	T	T	106508579	2	4	177	1	0	0	0	0	0	0	0	1	11916	755	27	1		1	PIK3CG	7	106508579	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08	91083412	106508579	52630084	39	12601											
CTTNBP2	83992	broad.mit.edu	37	chr7	117368153	117368153	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggcacttacttcactgtcaCttgggcatgcccaggaacta	9	12	2	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr7:117368153C>A	uc003vjf.2	-	17	4137	c.4045G>T	c.(4045-4047)GTG>TTG	p.V1349L		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1349										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TTCACTGTCACTTGGGCATGC	0.493													A	117368153	A	A	117368153	3	1	177	1	0	0	0	0	1	0	0	0	4045	565	20	5	974	5	CTTNBP2	7	117368153	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	10859574	117368153	41770510	40	12602											
RNF133	168433	broad.mit.edu	37	chr7	122338662	122338662	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tacaacctccccgttcaataAgtgcaagccaggtctctgag	8	13	2	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr7:122338662A>C	uc003vkj.1	-	1	547	c.311T>G	c.(310-312)CTT>CGT	p.L104R	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	104	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						CCGTTCAATAAGTGCAAGCCA	0.458													C	122338662	C	C	122338662	3	2	177	1	0	0	0	0	1	0	0	0	13439	72	3	5	823	5	RNF133	7	122338662	Missense_Mutation	SNP	A	TCGA-26-5135-01A-01D-1486-08	4970509	122338662	36800001	41	12603											
GCC1	79571	broad.mit.edu	37	chr7	127222596	127222596	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcagttgctccagttccaaGtccttctcggtgagcacagc	10	14	1	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr7:127222596G>A	uc003vma.2	-	2	2218	c.1800C>T	c.(1798-1800)GAC>GAT	p.D600D		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	600	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						CCAGTTCCAAGTCCTTCTCGG	0.627													A	127222596	A	A	127222596	2	1	177	1	0	0	0	0	0	0	0	1	6285	1020	36	3		3	GCC1	7	127222596	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08	4883934	127222596	31916067	42	12604											
KEL	3792	broad.mit.edu	37	chr7	142643377	142643377	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacgtgcctgtctcctccaCgcacttcatccatcgtgggc	9	16	2	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr7:142643377C>T	uc003wcb.2	-	11	1441	c.1231G>A	c.(1231-1233)GTG>ATG	p.V411M		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	411	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GTCTCCTCCACGCACTTCATC	0.567													T	142643377	T	T	142643377	3	4	177	1	0	0	0	0	1	0	0	0	8142	536	19	1	1003	1	KEL	7	142643377	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	15420781	142643377	16495286	43	12605											
ADAM7	8756	broad.mit.edu	37	chr8	24324411	24324411	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatataacctgagggtgccGtatggtgccaattattcctg	10	8	0	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr8:24324411G>A	uc003xeb.2	+	6	602	c.489G>A	c.(487-489)CCG>CCA	p.P163P	ADAM7_uc003xea.1_Silent_p.P163P	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	163	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TGAGGGTGCCGTATGGTGCCA	0.388													A	24324411	A	A	24324411	2	1	177	1	0	0	0	0	0	0	0	1	251	1132	40	1		1	ADAM7	8	24324411	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08		24324411	122039611	44	12606											
SLCO5A1	81796	broad.mit.edu	37	chr8	70667740	70667740	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgatttctccttcagaacatCgtcatcactaacagcatcaa	4	12	5	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr8:70667740C>T	uc003xyl.2	-	4	1884	c.1177G>A	c.(1177-1179)GAT>AAT	p.D393N	SLCO5A1_uc010lzb.2_Missense_Mutation_p.D393N|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.D393N|SLCO5A1_uc010lzc.2_Missense_Mutation_p.D393N	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	393	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TTCAGAACATCGTCATCACTA	0.363													T	70667740	T	T	70667740	3	4	177	1	0	0	0	0	1	0	0	0	14731	884	31	2	1397	2	SLCO5A1	8	70667740	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	46343329	70667740	75696282	45	12607											
MTSS1	9788	broad.mit.edu	37	chr8	125568545	125568545	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcaggtgggccgctggcGgtagtgggtcctcccccgtt	17	13	0	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr8:125568545G>A	uc003yrk.2	-	12	1866	c.1332C>T	c.(1330-1332)ACC>ACT	p.T444T	NDUFB9_uc011lim.1_Intron|MTSS1_uc003yrh.2_5'UTR|MTSS1_uc011lin.1_Silent_p.T218T|MTSS1_uc011lio.1_Silent_p.T334T|MTSS1_uc003yri.2_Silent_p.T162T|MTSS1_uc003yrj.2_Silent_p.T419T|MTSS1_uc003yrl.2_Silent_p.T448T	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	444					actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GGCCGCTGGCGGTAGTGGGTC	0.627													A	125568545	A	A	125568545	2	1	177	1	0	0	0	0	0	0	0	1	9962	1103	39	2		2	MTSS1	8	125568545	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08	54900805	125568545	20795477	46	12608											
CEL	1056	broad.mit.edu	37	chr9	135946656	135946656	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccgcccacgggtgactccggGgccccccccgtgccgcccac	12	23	0	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr9:135946656G>C	uc010naa.1	+	11	1792	c.1776G>C	c.(1774-1776)GGG>GGC	p.G592G		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	589	3.|17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GTGACTCCGGGGCCCCCCCCG	0.811													C	135946656	C	C	135946656	2	2	177	1	0	0	0	0	0	0	0	1	3209	1219	43	5		5	CEL	9	135946656	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08		135946656	5266775	47	12609											
RPL7A	6130	broad.mit.edu	37	chr9	136217156	136217156	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctggtggtgattgcacaCgacgtggatcccatcgaggt	14	10	0	1	rs142456845	by1000genomes	TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr9:136217156C>T	uc004cde.1	+	5	507	c.477C>T	c.(475-477)CAC>CAT	p.H159H	MED22_uc004cdc.2_5'Flank|MED22_uc004cdd.2_5'Flank|RPL7A_uc004cdf.1_Translation_Start_Site|SNORD36A_uc010naj.2_5'Flank|SNORD36C_uc010nak.2_5'Flank	NM_000972	NP_000963	P62424	RL7A_HUMAN	ribosomal protein L7a	159					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|membrane fraction|polysomal ribosome	RNA binding|structural constituent of ribosome				0				OV - Ovarian serous cystadenocarcinoma(145;4.93e-07)|Epithelial(140;4.09e-06)|all cancers(34;3.78e-05)		TGATTGCACACGACGTGGATC	0.522													T	136217156	T	T	136217156	2	4	177	1	0	0	0	0	0	0	0	1	13600	535	19	1		1	RPL7A	9	136217156	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08	270500	136217156	4996275	48	12610											
SVIL	6840	broad.mit.edu	37	chr10	29751331	29751331	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtttcttgagattttttcCtgtagttacacagattgcaa	8	6	1	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr10:29751331C>T	uc001iut.1	-	36	7031	c.6278_splice	c.e36-1	p.G2093_splice	LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Splice_Site_p.G1007_splice|SVIL_uc001iuu.1_Splice_Site_p.G1667_splice	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2						cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AGATTTTTTCCTGTAGTTACA	0.468													T	29751331	T	T	29751331	5	4	177	1	0	0	0	0	0	0	1	0	15418	695	24	3	379	3	SVIL	10	29751331	Splice_Site	SNP	C	TCGA-26-5135-01A-01D-1486-08		29751331	105783416	49	12611											
MUC5B	727897	broad.mit.edu	37	chr11	1250506	1250506	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcgaggaccactgtgtggaCggctgcttctgccccccagg	14	14	1	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr11:1250506C>T	uc009ycr.1	+	25	3177	c.3051C>T	c.(3049-3051)GAC>GAT	p.D1017D	MUC5B_uc009yct.1_Silent_p.D361D|MUC5B_uc001ltb.2_Silent_p.D361D|MUC5B_uc001lta.2_Silent_p.D29D	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	361	TIL 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTGTGTGGACGGCTGCTTCT	0.682													T	1250506	T	T	1250506	2	4	177	1	0	0	0	0	0	0	0	1	9979	535	19	1		1	MUC5B	11	1250506	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08		1250506	133756010	50	12612											
GAPDH	2597	broad.mit.edu	37	chr12	6647098	6647098	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acttcaacagcgacacccacTcctccacctttgacgctggg	7	17	1	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr12:6647098T>G	uc001qop.1	+	8	976	c.874T>G	c.(874-876)TCC>GCC	p.S292A	GAPDH_uc009zep.1_Missense_Mutation_p.S250A|GAPDH_uc001qoq.1_Missense_Mutation_p.S217A|GAPDH_uc001qor.1_Missense_Mutation_p.S251A|GAPDH_uc001qos.1_Missense_Mutation_p.S292A|GAPDH_uc001qot.1_Missense_Mutation_p.S292A|GAPDH_uc001qou.1_Missense_Mutation_p.S251A|GAPDH_uc001qov.1_Missense_Mutation_p.S250A|GAPDH_uc001qow.1_Missense_Mutation_p.S245A|GAPDH_uc001qox.1_Missense_Mutation_p.S118A	NM_002046	NP_002037	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	292					gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding				0					NADH(DB00157)	CGACACCCACTCCTCCACCTT	0.582											OREG0021628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	6647098	G	G	6647098	3	3	177	1	0	0	0	0	1	0	0	0	6236	1551	54	5	900	5	GAPDH	12	6647098	Missense_Mutation	SNP	T	TCGA-26-5135-01A-01D-1486-08		6647098	127204797	51	12613											
ATF7IP	55729	broad.mit.edu	37	chr12	14650695	14650695	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcagaagccacacttgaaGttagcacgcgttcagagtca	9	12	3	3			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr12:14650695G>A	uc001rbw.2	+	15	3659	c.3501G>A	c.(3499-3501)AAG>AAA	p.K1167K	ATF7IP_uc001rbx.2_Silent_p.K1166K|ATF7IP_uc001rby.3_Silent_p.K1167K|ATF7IP_uc001rca.2_Silent_p.K1167K	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	1167	Interaction with MBD1.|Fibronectin type-III.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						CACACTTGAAGTTAGCACGCG	0.547													A	14650695	A	A	14650695	2	1	177	1	0	0	0	0	0	0	0	1	1087	1020	36	3		3	ATF7IP	12	14650695	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08	8003597	14650695	119201200	52	12614											
PDE3A	5139	broad.mit.edu	37	chr12	20769164	20769164	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtcaagtctctttcctagCgcctgagaaggagtttgcct	10	10	2	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr12:20769164C>T	uc001reh.1	+	4	1292	c.1270C>T	c.(1270-1272)CGC>TGC	p.R424C		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	424					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TCTTTCCTAGCGCCTGAGAAG	0.428													T	20769164	T	T	20769164	3	4	177	1	0	0	0	0	1	0	0	0	11637	782	27	1	1284	1	PDE3A	12	20769164	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	6118469	20769164	113082731	53	12615											
SOAT2	8435	broad.mit.edu	37	chr12	53512677	53512677	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccattgccgctgcaggacGccctatgtcaggtggaatta	11	13	1	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr12:53512677G>A	uc001sbv.2	+	9	955	c.867G>A	c.(865-867)ACG>ACA	p.T289T	SOAT2_uc009zms.2_Intron	NM_003578	NP_003569	O75908	SOAT2_HUMAN	acyl-CoA:cholesterol acyltransferase 2	289					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			ovary(1)	1						GCTGCAGGACGCCCTATGTCA	0.532													A	53512677	A	A	53512677	2	1	177	1	0	0	0	0	0	0	0	1	14911	1074	38	1		1	SOAT2	12	53512677	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08	32743513	53512677	80339218	54	12616											
EFNB2	1948	broad.mit.edu	37	chr13	107187289	107187289	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acaccccagcagtacttccaCacggagtcccttctcacagc	6	18	1	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr13:107187289C>A	uc001vqi.2	-	1	49	c.24G>T	c.(22-24)GTG>GTT	p.V8V		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	8					cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					AGTACTTCCACACGGAGTCCC	0.542													A	107187289	A	A	107187289	2	1	177	1	0	0	0	0	0	0	0	1	4956	465	17	5		5	EFNB2	13	107187289	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08		107187289	7982589	55	12617											
CTSG	1511	broad.mit.edu	37	chr14	25043934	25043934	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgattatattgagggtggcGgatggctctgcgcgcagtga	16	7	1	3			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr14:25043934G>T	uc001wpq.2	-	3	323	c.286C>A	c.(286-288)CGC>AGC	p.R96S		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	96	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		TGAGGGTGGCGGATGGCTCTG	0.532													T	25043934	T	T	25043934	3	4	177	1	0	0	0	0	1	0	0	0	4035	1116	39	5	493	5	CTSG	14	25043934	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08		25043934	82305606	56	12618											
LRFN5	145581	broad.mit.edu	37	chr14	42356801	42356801	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttcactggatttctcctgaaGggaagcttatttcaaatgca	8	8	3	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr14:42356801G>T	uc001wvm.2	+	3	2171	c.973G>T	c.(973-975)GGG>TGG	p.G325W	LRFN5_uc010ana.2_Missense_Mutation_p.G325W	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	325	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTCTCCTGAAGGGAAGCTTAT	0.453										HNSCC(30;0.082)			T	42356801	T	T	42356801	3	4	177	1	0	0	0	0	1	0	0	0	8941	1000	35	5	975	5	LRFN5	14	42356801	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	17312867	42356801	64992739	57	12619											
FOXN3	1112	broad.mit.edu	37	chr14	89647054	89647054	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccccacttacctcatggccGctgtcaccccaatgggagtg	9	16	2	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr14:89647054G>A	uc001xxo.3	-	6	1045	c.908C>T	c.(907-909)GCG>GTG	p.A303V	FOXN3_uc001xxn.3_Missense_Mutation_p.A281V|FOXN3_uc010atk.2_Missense_Mutation_p.A281V	NM_001085471	NP_001078940	O00409	FOXN3_HUMAN	checkpoint suppressor 1 isoform 1	303					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(2)|ovary(1)	3						CCTCATGGCCGCTGTCACCCC	0.637													A	89647054	A	A	89647054	3	1	177	1	0	0	0	0	1	0	0	0	6021	1087	38	1	572	1	FOXN3	14	89647054	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	47290253	89647054	17702486	58	12620											
BAHD1	22893	broad.mit.edu	37	chr15	40758215	40758215	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggttcccccctctgcagaCtattccaccccaccccaccg	5	22	1	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr15:40758215C>T	uc001zlu.2	+	7	2300	c.2229C>T	c.(2227-2229)GAC>GAT	p.D743D	BAHD1_uc001zlt.2_Silent_p.D742D|BAHD1_uc010bbp.1_Silent_p.D739D|BAHD1_uc001zlv.2_Silent_p.D740D	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	743	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CCTCTGCAGACTATTCCACCC	0.602													T	40758215	T	T	40758215	2	4	177	1	0	0	0	0	0	0	0	1	1297	564	20	3		3	BAHD1	15	40758215	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08		40758215	61773177	59	12621											
TARSL2	123283	broad.mit.edu	37	chr15	102242566	102242566	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtttccatttccggattgCcctcccaatatgttgaggaa	8	10	0	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr15:102242566C>T	uc002bxm.2	-	9	1152	c.1097G>A	c.(1096-1098)GGC>GAC	p.G366D	TARSL2_uc002bxl.2_5'UTR|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	366					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCCGGATTGCCCTCCCAATA	0.353													T	102242566	T	T	102242566	3	4	177	1	0	0	0	0	1	0	0	0	15558	739	26	3	1355	3	TARSL2	15	102242566	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	61484351	102242566	288826	60	12622											
IL32	9235	broad.mit.edu	37	chr16	3119233	3119233	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caggccctctggaaacagttCcagagtttctgctgctctct	9	13	3	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr16:3119233C>T	uc002cto.2	+	6	793	c.582C>T	c.(580-582)TTC>TTT	p.F194F	IL32_uc002ctk.2_Intron|IL32_uc010uwp.1_Silent_p.F128F|IL32_uc010btb.2_Silent_p.F138F|IL32_uc002ctl.2_Silent_p.F148F|IL32_uc002ctm.2_Silent_p.F148F|IL32_uc002ctn.2_Silent_p.F148F|IL32_uc002cts.3_Silent_p.F148F|IL32_uc002ctp.2_Silent_p.F128F|IL32_uc002ctq.2_Silent_p.F194F|IL32_uc002ctr.2_Silent_p.F128F|IL32_uc002ctt.2_Silent_p.F148F|IL32_uc010uwr.1_Silent_p.F108F|IL32_uc002ctu.2_Silent_p.F139F	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	194					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						GGAAACAGTTCCAGAGTTTCT	0.612													T	3119233	T	T	3119233	2	4	177	1	0	0	0	0	0	0	0	1	7692	854	30	3		3	IL32	16	3119233	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08		3119233	87235520	61	12623											
ITGAM	3684	broad.mit.edu	37	chr16	31309135	31309135	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctggggccgctttggggcaGccctaacagtgctgggggac	17	12	0	0			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr16:31309135G>T	uc002ebq.2	+	14	1665	c.1567G>T	c.(1567-1569)GCC>TCC	p.A523S	ITGAM_uc002ebr.2_Missense_Mutation_p.A524S|ITGAM_uc010cam.1_Intron|ITGAM_uc010can.2_Intron	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	523	FG-GAP 6.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CTTTGGGGCAGCCCTAACAGT	0.607													T	31309135	T	T	31309135	3	4	177	1	0	0	0	0	1	0	0	0	7887	971	34	5	1624	5	ITGAM	16	31309135	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	28189902	31309135	59045618	62	12624											
CHST5	23563	broad.mit.edu	37	chr16	75564025	75564025	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccatcaggtagaagacgtcGgggtgctggctgaagagctg	16	8	1	4			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr16:75564025G>A	uc002fei.2	-	3	1653	c.258C>T	c.(256-258)CCC>CCT	p.P86P	CHST5_uc002fej.1_Silent_p.P92P	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	86	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGAAGACGTCGGGGTGCTGGC	0.677													A	75564025	A	A	75564025	2	1	177	1	0	0	0	0	0	0	0	1	3407	1103	39	2		2	CHST5	16	75564025	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08	44254890	75564025	14790728	63	12625											
SUPT6H	6830	broad.mit.edu	37	chr17	27010834	27010834	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaaggaatatgtcataaaGgtgaggacagagactcatga	12	6	2	3			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr17:27010834G>A	uc002hby.2	+	17	2319	c.2229G>A	c.(2227-2229)AAG>AAA	p.K743K	SUPT6H_uc010crt.2_Silent_p.K743K	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	743					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					ATGTCATAAAGGTGAGGACAG	0.294													A	27010834	A	A	27010834	2	1	177	1	0	0	0	0	0	0	0	1	15397	1014	35	3		3	SUPT6H	17	27010834	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08		27010834	54184376	64	12626											
DSG4	147409	broad.mit.edu	37	chr18	28968937	28968937	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgataacgctccagtcttttCgcaaagtgtatacacagcca	7	11	1	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr18:28968937C>T	uc002kwq.2	+	5	608	c.473C>T	c.(472-474)TCG>TTG	p.S158L	DSG4_uc002kwr.2_Missense_Mutation_p.S158L	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	158	Cadherin 2.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCAGTCTTTTCGCAAAGTGTA	0.413													T	28968937	T	T	28968937	3	4	177	1	0	0	0	0	1	0	0	0	4779	893	31	2	491	2	DSG4	18	28968937	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08		28968937	49108311	65	12627											
ZNF57	126295	broad.mit.edu	37	chr19	2918067	2918067	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgagtgtaaacaatgtggaaAaaccttcacttggtcctcaa	8	8	2	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr19:2918067A>G	uc002lwr.2	+	4	1596	c.1448A>G	c.(1447-1449)AAA>AGA	p.K483R	ZNF57_uc010xha.1_Missense_Mutation_p.K451R	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	483	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		CAATGTGGAAAAACCTTCACT	0.448													G	2918067	G	G	2918067	3	3	177	1	0	0	0	0	1	0	0	0	17998	14	1	4	1462	4	ZNF57	19	2918067	Missense_Mutation	SNP	A	TCGA-26-5135-01A-01D-1486-08		2918067	56210916	66	12628											
MUC16	94025	broad.mit.edu	37	chr19	9062081	9062081	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gacatggatgttcccctagaGgatatcacttctgtcctgga	10	10	2	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr19:9062081G>C	uc002mkp.2	-	3	25569	c.25365C>G	c.(25363-25365)TCC>TCG	p.S8455S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8457	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTCCCCTAGAGGATATCACTT	0.522													C	9062081	C	C	9062081	2	2	177	1	0	0	0	0	0	0	0	1	9973	987	35	5		5	MUC16	19	9062081	Silent	SNP	G	TCGA-26-5135-01A-01D-1486-08	6144014	9062081	50066902	67	12629											
FBXL12	54850	broad.mit.edu	37	chr19	9921682	9921682	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgaccctcccaccccagccCctgcagctcaaggactctga	7	20	2	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr19:9921682C>T	uc002mme.2	-	3	1113	c.871G>A	c.(871-873)GGG>AGG	p.G291R	FBXL12_uc002mmd.2_Missense_Mutation_p.G238R|FBXL12_uc002mmf.2_Missense_Mutation_p.G238R|FBXL12_uc002mmg.2_Missense_Mutation_p.G238R|FBXL12_uc002mmh.2_Missense_Mutation_p.G238R	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	291	LRR 8.						protein binding			lung(1)|kidney(1)	2						CACCCCAGCCCCTGCAGCTCA	0.612													T	9921682	T	T	9921682	3	4	177	1	0	0	0	0	1	0	0	0	5708	623	22	3	113	3	FBXL12	19	9921682	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	859601	9921682	49207301	68	12630											
JAK3	3718	broad.mit.edu	37	chr19	17945947	17945947	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcactcagcttgatgaagggCgggctcccatcagccccctc	10	16	3	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr19:17945947C>T	uc002nhn.3	-	15	2092	c.1992G>A	c.(1990-1992)CCG>CCA	p.P664P	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Silent_p.P664P	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	664	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						TGATGAAGGGCGGGCTCCCAT	0.637		2	Mis		acute megakaryocytic leukemia|								T	17945947	T	T	17945947	2	4	177	1	0	0	0	0	0	0	0	1	7939	755	27	1		1	JAK3	19	17945947	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08	8024265	17945947	41183036	69	12631											
CD22	933	broad.mit.edu	37	chr19	35837570	35837570	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagcggcctcaggcacaagaAaatgtggactatgtgatcct	12	9	1	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr19:35837570A>C	uc010edt.2	+	14	2591	c.2514A>C	c.(2512-2514)GAA>GAC	p.E838D	CD22_uc010xst.1_Missense_Mutation_p.E666D|CD22_uc010edu.2_Missense_Mutation_p.E750D|CD22_uc010edv.2_3'UTR|CD22_uc002nzb.3_Missense_Mutation_p.E661D|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	838	Cytoplasmic (Potential).				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AGGCACAAGAAAATGTGGACT	0.552													C	35837570	C	C	35837570	3	2	177	1	0	0	0	0	1	0	0	0	2985	11	1	5	2564	5	CD22	19	35837570	Missense_Mutation	SNP	A	TCGA-26-5135-01A-01D-1486-08	17891623	35837570	23291413	70	12632											
SIPA1L3	23094	broad.mit.edu	37	chr19	38572329	38572329	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcccttgggattctgggccCagaatggcagcatgtcccag	12	13	1	1			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr19:38572329C>T	uc002ohk.2	+	3	633	c.124C>T	c.(124-126)CAG>TAG	p.Q42*		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	42					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ATTCTGGGCCCAGAATGGCAG	0.572													T	38572329	T	T	38572329	4	4	177	1	0	0	0	0	0	1	0	0	14331	595	21	3	126	3	SIPA1L3	19	38572329	Nonsense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	2734759	38572329	20556654	71	12633											
ZNF285	26974	broad.mit.edu	37	chr19	44891167	44891167	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctccagtggacttgaagaaCggagcttgaactaaagcact	10	10	0	3			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr19:44891167C>T	uc002ozd.3	-	4	1327	c.1240G>A	c.(1240-1242)GTT>ATT	p.V414I	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Missense_Mutation_p.V421I	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	414	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						ACTTGAAGAACGGAGCTTGAA	0.488													T	44891167	T	T	44891167	3	4	177	1	0	0	0	0	1	0	0	0	17819	536	19	1	536	1	ZNF285	19	44891167	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	6318838	44891167	14237816	72	12634											
CKM	1158	broad.mit.edu	37	chr19	45821144	45821144	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggtttgtagcccccgtggCgatccgagatgatggggtca	16	9	1	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr19:45821144C>T	uc002pbd.2	-	3	361	c.287G>A	c.(286-288)CGC>CAC	p.R96H		NM_001824	NP_001815	P06732	KCRM_HUMAN	muscle creatine kinase	96	Phosphagen kinase N-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			skin(1)	1		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	GCCCCCGTGGCGATCCGAGAT	0.582													T	45821144	T	T	45821144	3	4	177	1	0	0	0	0	1	0	0	0	3448	768	27	1	882	1	CKM	19	45821144	Missense_Mutation	SNP	C	TCGA-26-5135-01A-01D-1486-08	929977	45821144	13307839	73	12635											
ZNF805	390980	broad.mit.edu	37	chr19	57765629	57765629	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagcatccacactggagagaAgccctatgagtgcatggagt	12	10	0	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr19:57765629A>C	uc010ygt.1	+	4	1649	c.1442A>C	c.(1441-1443)AAG>ACG	p.K481T	ZNF805_uc010ygu.1_Missense_Mutation_p.K348T	NM_001023563	NP_001018857	Q5CZA5	ZN805_HUMAN	zinc finger protein 805 isoform 1	481					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTGGAGAGAAGCCCTATGAG	0.527													C	57765629	C	C	57765629	3	2	177	1	0	0	0	0	1	0	0	0	18169	72	3	5	1456	5	ZNF805	19	57765629	Missense_Mutation	SNP	A	TCGA-26-5135-01A-01D-1486-08	11944485	57765629	1363354	74	12636											
GGTLC1	92086	broad.mit.edu	37	chr20	23967182	23967182	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaactcgggcttgtagtaggAgatcgggtgagtggtgtcgt	18	5	0	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr20:23967182A>G	uc002wts.2	-	2	200	c.67T>C	c.(67-69)TCC>CCC	p.S23P	GGTLC1_uc002wtu.2_Missense_Mutation_p.S23P	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	23							gamma-glutamyltransferase activity			ovary(1)	1						TTGTAGTAGGAGATCGGGTGA	0.632													G	23967182	G	G	23967182	3	3	177	1	0	0	0	0	1	0	0	0	6365	304	11	4	630	4	GGTLC1	20	23967182	Missense_Mutation	SNP	A	TCGA-26-5135-01A-01D-1486-08		23967182	39058338	75	12637											
MATN4	8785	broad.mit.edu	37	chr20	43922452	43922452	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagatcctccaggcgcgcCgtcagctgggccagtgagcg	14	15	1	2			TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr20:43922452C>T	uc002xnn.2	-	10	1888	c.1701G>A	c.(1699-1701)ACG>ACA	p.T567T	MATN4_uc002xno.2_Silent_p.T526T|MATN4_uc002xnp.2_Silent_p.T485T	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	608	Potential.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				CCAGGCGCGCCGTCAGCTGGG	0.687													T	43922452	T	T	43922452	2	4	177	1	0	0	0	0	0	0	0	1	9336	639	23	2		2	MATN4	20	43922452	Silent	SNP	C	TCGA-26-5135-01A-01D-1486-08	19955270	43922452	19103068	76	12638											
FAM65C	140876	broad.mit.edu	37	chr20	49232571	49232571	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcctggtgtctttgtggcGtccagacaggtggtccagct	13	12	1	1	rs147229572		TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr20:49232571G>A	uc002xvm.2	-	4	622	c.304C>T	c.(304-306)CGC>TGC	p.R102C	FAM65C_uc010zyt.1_Missense_Mutation_p.R106C|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.R102C|MIR1302-5_hsa-mir-1302-5|MI0006366_5'Flank	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	102										ovary(2)	2						TCTTTGTGGCGTCCAGACAGG	0.542													A	49232571	A	A	49232571	3	1	177	1	0	0	0	0	1	0	0	0	5601	1145	40	1	2612	1	FAM65C	20	49232571	Missense_Mutation	SNP	G	TCGA-26-5135-01A-01D-1486-08	5310119	49232571	13792949	77	12639											
TAF4	6874	broad.mit.edu	37	chr20	60572701	60572706	+	In_Frame_Del	DEL	TTTGTG	-	-													gttggcgtcccgctgtctcaTttgtgccagttcctgttgct							TCGA-26-5135-01A-01D-1486-08	TCGA-26-5135-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ce48f01-2f61-49d9-a56a-7438bf4a37d7	8f36ad24-c425-4474-9d03-a5198e2e4901	g.chr20:60572701_60572706delTTTGTG	uc002ybs.2	-	14	2990_2995	c.2990_2995delCACAAA	c.(2989-2997)GCACAAATG>GTG	p.997_999AQM>V		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	997_999					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			CGCTGTCTCATTTGTGCCAGTTCCTG	0.471													-	60572706	-	-	60572701	7	5	177	1	0	1	0	1	0	0	0	0	15523	1493	52	0	270	0	TAF4	20	60572701	In_Frame_Del	DEL	TTTGTG	TCGA-26-5135-01A-01D-1486-08	11340130	60572701	2452819	78	12640											
PIK3CD	5293	broad.mit.edu	37	chr1	9780231	9780231	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtaaccccaacacggatagCgccgctgccctgctcatctg	9	16	2	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:9780231C>T	uc001aqb.3	+	11	1609	c.1401C>T	c.(1399-1401)AGC>AGT	p.S467S	PIK3CD_uc010oaf.1_Silent_p.S467S|PIK3CD_uc001aqe.3_Silent_p.S432S	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	467					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		ACACGGATAGCGCCGCTGCCC	0.662													T	9780231	T	T	9780231	2	4	178	1	0	0	0	0	0	0	0	1	11915	767	27	1		1	PIK3CD	1	9780231	Silent	SNP	C	TCGA-26-5136-01B-01D-1486-08		9780231	239470390	1	12641											
MUL1	79594	broad.mit.edu	37	chr1	20828674	20828674	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcgtttctttaacagaccGcacagctcctaagtggacac	8	12	1	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:20828674G>A	uc001bdi.3	-	3	374	c.217C>T	c.(217-219)CGG>TGG	p.R73W		NM_024544	NP_078820	Q969V5	MUL1_HUMAN	mitochondrial ubiquitin ligase activator of NFKB	73	Mitochondrial intermembrane (Potential).				activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		TTAACAGACCGCACAGCTCCT	0.388													A	20828674	A	A	20828674	3	1	178	1	0	0	0	0	1	0	0	0	9984	1086	38	1	849	1	MUL1	1	20828674	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	11048443	20828674	228421947	2	12642											
ZNF644	84146	broad.mit.edu	37	chr1	91404393	91404393	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaattaagtttttgcaaaaCgacaacagtcattttatgca	6	6	1	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:91404393C>T	uc001dnw.2	-	3	2660	c.2518G>A	c.(2518-2520)GTT>ATT	p.V840I	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.V840I	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	840					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TTTTGCAAAACGACAACAGTC	0.363													T	91404393	T	T	91404393	3	4	178	1	0	0	0	0	1	0	0	0	18057	536	19	1	1481	1	ZNF644	1	91404393	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	70575719	91404393	157846228	3	12643											
AMPD1	270	broad.mit.edu	37	chr1	115220069	115220069	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccactcatcaggactgcGgccatagatggacaggcggg	14	12	2	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:115220069G>A	uc001efe.1	-	10	1375	c.1291C>T	c.(1291-1293)CGC>TGC	p.R431C	AMPD1_uc001eff.1_Missense_Mutation_p.R427C	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	431					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TCAGGACTGCGGCCATAGATG	0.567													A	115220069	A	A	115220069	3	1	178	1	0	0	0	0	1	0	0	0	585	1116	39	2	980	2	AMPD1	1	115220069	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	23815676	115220069	134030552	4	12644											
PPIAL4G	644591	broad.mit.edu	37	chr1	143767630	143767630	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatagatggacttgtcaccGgtgccattagggtgtgtgaa	13	8	1	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:143767630G>A	uc001ejt.2	-	1	252	c.219C>T	c.(217-219)ACC>ACT	p.T73T		NM_001123068	NP_001116540	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	73	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity				0						ACTTGTCACCGGTGCCATTAG	0.468													A	143767630	A	A	143767630	2	1	178	1	0	0	0	0	0	0	0	1	12318	1103	39	2		2	PPIAL4G	1	143767630	Silent	SNP	G	TCGA-26-5136-01B-01D-1486-08	28547561	143767630	105482991	5	12645											
PEAR1	375033	broad.mit.edu	37	chr1	156879622	156879622	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgccagctgccagtgtgcCcatgaggcagtctgcagccc	12	14	1	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:156879622C>T	uc001fqj.1	+	12	1607	c.1491C>T	c.(1489-1491)GCC>GCT	p.A497A	PEAR1_uc001fqk.1_Silent_p.A122A	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	497	EGF-like 6.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCAGTGTGCCCATGAGGCAG	0.662													T	156879622	T	T	156879622	2	4	178	1	0	0	0	0	0	0	0	1	11712	610	22	3		3	PEAR1	1	156879622	Silent	SNP	C	TCGA-26-5136-01B-01D-1486-08	13111992	156879622	92370999	6	12646											
PVRL4	81607	broad.mit.edu	37	chr1	161049529	161049529	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggcggcggctgctccacgCggccctcgtaagccgggctc	17	16	0	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:161049529C>T	uc001fxo.2	-	2	589	c.290G>A	c.(289-291)CGC>CAC	p.R97H		NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	97	Ig-like V-type 1.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTGCTCCACGCGGCCCTCGTA	0.687													T	161049529	T	T	161049529	3	4	178	1	0	0	0	0	1	0	0	0	12842	768	27	1	1274	1	PVRL4	1	161049529	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	4169907	161049529	88201092	7	12647											
SIPA1L2	57568	broad.mit.edu	37	chr1	232561420	232561420	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtgctgaacagaatgtcGttgggcagggcctggtcaag	17	7	1	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:232561420G>A	uc001hvg.2	-	16	4703	c.4545C>T	c.(4543-4545)AAC>AAT	p.N1515N	SIPA1L2_uc001hvf.2_Silent_p.N589N	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1515					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				ACAGAATGTCGTTGGGCAGGG	0.642													A	232561420	A	A	232561420	2	1	178	1	0	0	0	0	0	0	0	1	14330	1136	40	1		1	SIPA1L2	1	232561420	Silent	SNP	G	TCGA-26-5136-01B-01D-1486-08	71511891	232561420	16689201	8	12648											
SIPA1L2	57568	broad.mit.edu	37	chr1	232626679	232626679	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtgagttggaagcctgtcGcaaacactgaatgctcagct	13	9	1	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:232626679G>A	uc001hvg.2	-	3	1905	c.1747C>T	c.(1747-1749)CGA>TGA	p.R583*		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	583					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GAAGCCTGTCGCAAACACTGA	0.463													A	232626679	A	A	232626679	4	1	178	1	0	0	0	0	0	1	0	0	14330	1095	38	1	3497	1	SIPA1L2	1	232626679	Nonsense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	65259	232626679	16623942	9	12649											
OR2T6	254879	broad.mit.edu	37	chr1	248551010	248551010	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttcggtgtcatttgtgccgTcttcttcatggccatgatag	10	9	4	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr1:248551010T>C	uc001iei.1	+	1	101	c.101T>C	c.(100-102)GTC>GCC	p.V34A		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTTGTGCCGTCTTCTTCATG	0.463													C	248551010	C	C	248551010	3	2	178	1	0	0	0	0	1	0	0	0	11029	1667	58	4	103	4	OR2T6	1	248551010	Missense_Mutation	SNP	T	TCGA-26-5136-01B-01D-1486-08	15924331	248551010	699611	10	12650											
MYCN	4613	broad.mit.edu	37	chr2	16082359	16082359	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagtttgagctgctgcccaCgcccccgctgtcgcccagcc	11	18	0	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr2:16082359C>T	uc002rci.2	+	2	473	c.173C>T	c.(172-174)ACG>ATG	p.T58M	MYCNOS_uc002rch.1_5'Flank|MYCN_uc010yjr.1_Missense_Mutation_p.T50M	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	58					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CTGCTGCCCACGCCCCCGCTG	0.677			A		neuroblastoma								T	16082359	T	T	16082359	3	4	178	1	0	0	0	0	1	0	0	0	10021	536	19	1	175	1	MYCN	2	16082359	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08		16082359	227117014	11	12651											
SCN9A	6335	broad.mit.edu	37	chr2	167141183	167141183	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggggcacaaacagtgagcccCttctgctctcattgtctcca	9	14	3	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr2:167141183C>G	uc010fpl.2	-	12	2095	c.1754G>C	c.(1753-1755)AGG>ACG	p.R585T	uc002udp.2_Intron|SCN9A_uc002udr.1_Missense_Mutation_p.R456T|SCN9A_uc002uds.1_Missense_Mutation_p.R456T|SCN9A_uc002udt.1_Missense_Mutation_p.R456T	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	585						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CAGTGAGCCCCTTCTGCTCTC	0.502													G	167141183	G	G	167141183	3	3	178	1	0	0	0	0	1	0	0	0	13925	681	24	5	4243	5	SCN9A	2	167141183	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	151058824	167141183	76058190	12	12652											
COL6A3	1293	broad.mit.edu	37	chr2	238270475	238270475	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gctttctcggcaatgttgtcCtaccgaaaggaagagaaacc	10	10	1	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr2:238270475C>G	uc002vwl.2	-	15	6349	c.6064_splice	c.e15-1	p.D2022_splice	COL6A3_uc002vwo.2_Splice_Site_p.D1816_splice|COL6A3_uc010znj.1_Splice_Site_p.D1415_splice	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor						axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CAATGTTGTCCTACCGAAAGG	0.527													G	238270475	G	G	238270475	5	3	178	1	0	0	0	0	0	0	1	0	3701	695	24	5	3590	5	COL6A3	2	238270475	Splice_Site	SNP	C	TCGA-26-5136-01B-01D-1486-08	71129292	238270475	4928898	13	12653											
OXSM	54995	broad.mit.edu	37	chr3	25832620	25832620	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtttttcggaactgtgccaAtatccagattgcataggcga	10	8	0	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr3:25832620A>G	uc003cdn.2	+	2	216	c.109A>G	c.(109-111)ATA>GTA	p.I37V	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_5'UTR|OXSM_uc010hfh.2_Missense_Mutation_p.I37V	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	37					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						AACTGTGCCAATATCCAGATT	0.428													G	25832620	G	G	25832620	3	3	178	1	0	0	0	0	1	0	0	0	11335	101	4	4	111	4	OXSM	3	25832620	Missense_Mutation	SNP	A	TCGA-26-5136-01B-01D-1486-08		25832620	172189810	14	12654											
PIK3CA	5290	broad.mit.edu	37	chr3	178916882	178916882	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatgaaacaagacgactttGtgaccttcggctttttcaac	8	9	1	4			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr3:178916882G>A	uc003fjk.2	+	2	426	c.269G>A	c.(268-270)TGT>TAT	p.C90Y		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	90	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGACGACTTTGTGACCTTCGG	0.368		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178916882	A	A	178916882	3	1	178	1	0	0	0	0	1	0	0	0	11913	1377	48	3	271	3	PIK3CA	3	178916882	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	153084262	178916882	19105548	15	12655											
UGT2B10	7365	broad.mit.edu	37	chr4	69696492	69696492	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cactctttggatgtgattggGttcctgctggcttgtgtggc	14	8	1	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr4:69696492G>T	uc003hee.2	+	6	1507	c.1482G>T	c.(1480-1482)GGG>GGT	p.G494G	UGT2B10_uc011cam.1_Silent_p.G410G	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	494	Helical; (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						ATGTGATTGGGTTCCTGCTGG	0.458													T	69696492	T	T	69696492	2	4	178	1	0	0	0	0	0	0	0	1	16953	1248	44	5		5	UGT2B10	4	69696492	Silent	SNP	G	TCGA-26-5136-01B-01D-1486-08		69696492	121457784	16	12656											
FAM13A	10144	broad.mit.edu	37	chr4	89941642	89941642	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaatgaatcgaggctgcaaCgctgaggtgatcagactgtc	13	8	1	5	rs147082682	byFrequency	TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr4:89941642C>T	uc003hse.1	-	3	604	c.396G>A	c.(394-396)GCG>GCA	p.A132A	FAM13A_uc003hsf.1_5'UTR|FAM13A_uc003hsh.1_5'UTR|FAM13A_uc003hsi.2_Silent_p.A132A|FAM13A_uc003hsj.2_Silent_p.A132A	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	132	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						GAGGCTGCAACGCTGAGGTGA	0.423													T	89941642	T	T	89941642	2	4	178	1	0	0	0	0	0	0	0	1	5452	523	19	1		1	FAM13A	4	89941642	Silent	SNP	C	TCGA-26-5136-01B-01D-1486-08	20245150	89941642	101212634	17	12657											
PTGER4	5734	broad.mit.edu	37	chr5	40681502	40681502	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacgtggacaagcgattggCgggcctcacgctctttgcag	13	12	2	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr5:40681502C>T	uc003jlz.2	+	2	999	c.407C>T	c.(406-408)GCG>GTG	p.A136V		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	136	Helical; Name=4; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						AAGCGATTGGCGGGCCTCACG	0.597											OREG0016588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	40681502	T	T	40681502	3	4	178	1	0	0	0	0	1	0	0	0	12745	768	27	1	409	1	PTGER4	5	40681502	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08		40681502	140233758	18	12658											
HSP90AB1	3326	broad.mit.edu	37	chr6	44217321	44217321	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cattcatggaggctcttcagGtattgcagttctgtaggcat	11	8	4	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr6:44217321G>T	uc003oxa.1	+	3	438	c.354_splice	c.e3+1	p.Q118_splice	HSP90AB1_uc011dvr.1_Splice_Site_p.Q118_splice|HSP90AB1_uc003oxb.1_Splice_Site_p.Q118_splice|HSP90AB1_uc011dvs.1_Splice_Site|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta						axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGCTCTTCAGGTATTGCAGTT	0.403													T	44217321	T	T	44217321	5	4	178	1	0	0	0	0	0	0	1	0	7402	1275	44	5	361	5	HSP90AB1	6	44217321	Splice_Site	SNP	G	TCGA-26-5136-01B-01D-1486-08		44217321	126897746	19	12659											
RABGEF1	27342	broad.mit.edu	37	chr7	66262470	66262470	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actgatgatgagaagaaagaTcttgccattcaaaagagaat	9	5	2	6			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr7:66262470T>C	uc011kee.1	+	6	911	c.747T>C	c.(745-747)GAT>GAC	p.D249D	RABGEF1_uc003tvf.2_Silent_p.D108D|RABGEF1_uc003tvg.2_Silent_p.D43D|RABGEF1_uc010lag.2_Silent_p.D235D|RABGEF1_uc003tvh.2_Silent_p.D235D|RABGEF1_uc003tvi.2_Silent_p.D69D	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	452	VPS9.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						AGAAGAAAGATCTTGCCATTC	0.358													C	66262470	C	C	66262470	2	2	178	1	0	0	0	0	0	0	0	1	12966	1432	50	4		4	RABGEF1	7	66262470	Silent	SNP	T	TCGA-26-5136-01B-01D-1486-08		66262470	92876193	20	12660											
TRIM50	135892	broad.mit.edu	37	chr7	72734159	72734159	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactcacgacgattcgggtcCggttgttcaccagtttggcg	12	12	2	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr7:72734159C>T	uc010lbd.1	-	3	607	c.482G>A	c.(481-483)CGG>CAG	p.R161Q	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Missense_Mutation_p.R161Q|TRIM50_uc003txz.1_Missense_Mutation_p.R161Q	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	161	Potential.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1						GATTCGGGTCCGGTTGTTCAC	0.562													T	72734159	T	T	72734159	3	4	178	1	0	0	0	0	1	0	0	0	16523	652	23	2	1001	2	TRIM50	7	72734159	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	6471689	72734159	86404504	21	12661											
BAIAP2L1	55971	broad.mit.edu	37	chr7	97922864	97922864	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggtgccgagcgatcattcGtcacagtcgggcggagtttc	15	10	2	0	rs140138864		TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr7:97922864G>A	uc003upj.2	-	14	1768	c.1505C>T	c.(1504-1506)ACG>ATG	p.T502M		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	502	Binds F-actin.			Missing: Loss ability to induce the formation of actin clusters; induce the formation of long filopodia.	filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			GCGATCATTCGTCACAGTCGG	0.547													A	97922864	A	A	97922864	3	1	178	1	0	0	0	0	1	0	0	0	1302	1145	40	1	34	1	BAIAP2L1	7	97922864	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	25188705	97922864	61215799	22	12662											
RELN	5649	broad.mit.edu	37	chr7	103389896	103389896	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atatttggatttaattgcagTtggtggtaggagtcaaagtc	12	3	1	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr7:103389896T>C	uc003vca.2	-	6	793	c.633A>G	c.(631-633)CAA>CAG	p.Q211Q	RELN_uc010liz.2_Silent_p.Q211Q	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	211					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTAATTGCAGTTGGTGGTAGG	0.353													C	103389896	C	C	103389896	2	2	178	1	0	0	0	0	0	0	0	1	13220	1722	60	4		4	RELN	7	103389896	Silent	SNP	T	TCGA-26-5136-01B-01D-1486-08	5467032	103389896	55748767	23	12663											
PARP12	64761	broad.mit.edu	37	chr7	139724367	139724367	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cactcctgtgcgctcactgtCggctgctgaacagggagccc	12	15	1	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr7:139724367C>T	uc003vvl.1	-	12	2973	c.2099G>A	c.(2098-2100)CGA>CAA	p.R700Q	PARP12_uc003vvk.1_Missense_Mutation_p.R486Q|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	700						nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					CGCTCACTGTCGGCTGCTGAA	0.522													T	139724367	T	T	139724367	3	4	178	1	0	0	0	0	1	0	0	0	11457	884	31	2	10	2	PARP12	7	139724367	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	36334471	139724367	19414296	24	12664											
OR2F2	135948	broad.mit.edu	37	chr7	143632582	143632582	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccagctgctggcacattttcTtgcagaacataaagccatcc	7	13	1	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr7:143632582T>C	uc011ktv.1	+	1	257	c.257T>C	c.(256-258)CTT>CCT	p.L86P		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					GCACATTTTCTTGCAGAACAT	0.522													C	143632582	C	C	143632582	3	2	178	1	0	0	0	0	1	0	0	0	10997	1609	56	4	259	4	OR2F2	7	143632582	Missense_Mutation	SNP	T	TCGA-26-5136-01B-01D-1486-08	3908215	143632582	15506081	25	12665											
SLC4A2	6522	broad.mit.edu	37	chr7	150759094	150759094	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgagcagcgcccctcggcGccccgccaagggcgcagatt	13	17	0	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr7:150759094G>A	uc003wit.3	+	2	276	c.20G>A	c.(19-21)CGC>CAC	p.R7H	SLC4A2_uc011kve.1_5'Flank|SLC4A2_uc003wiu.3_5'Flank	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	7	Cytoplasmic (Potential).|Pro-rich.			R -> L (in Ref. 1; CAA44067).	bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCCCTCGGCGCCCCGCCAAG	0.667													A	150759094	A	A	150759094	3	1	178	1	0	0	0	0	1	0	0	0	14654	1087	38	1	22	1	SLC4A2	7	150759094	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	7126512	150759094	8379569	26	12666											
TRIM14	9830	broad.mit.edu	37	chr9	100857227	100857227	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccttaaagaagctcttgaCgggctcaaaggagaggggca	14	9	2	3	rs149392923		TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr9:100857227C>T	uc004ayd.2	-	4	640	c.622G>A	c.(622-624)GTC>ATC	p.V208I	TRIM14_uc004ayf.1_Missense_Mutation_p.V115I|TRIM14_uc011luz.1_5'Flank|TRIM14_uc011lva.1_5'Flank|TRIM14_uc004ayg.1_Missense_Mutation_p.V208I|TRIM14_uc004ayh.1_Missense_Mutation_p.V208I|TRIM14_uc004ayi.1_Missense_Mutation_p.V208I|TRIM14_uc004ayj.1_Missense_Mutation_p.V115I	NM_033220	NP_150089	Q14142	TRI14_HUMAN	tripartite motif protein TRIM14 isoform alpha	208						cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)				AAGCTCTTGACGGGCTCAAAG	0.582													T	100857227	T	T	100857227	3	4	178	1	0	0	0	0	1	0	0	0	16486	536	19	1	718	1	TRIM14	9	100857227	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08		100857227	40356204	27	12667											
C9orf163	158055	broad.mit.edu	37	chr9	139379109	139379109	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggcggctggtgagggaggGggtgatatccgtgccacgcc	19	11	0	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr9:139379109G>A	uc004chy.2	+	1	1163	c.209G>A	c.(208-210)GGG>GAG	p.G70E	SEC16A_uc004chx.2_5'Flank|SEC16A_uc010nbo.1_5'Flank	NM_152571	NP_689784	Q8N9P6	CI163_HUMAN	hypothetical protein LOC158055	70							protein binding				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.36e-06)|Epithelial(140;5.65e-06)		GTGAGGGAGGGGGTGATATCC	0.687													A	139379109	A	A	139379109	3	1	178	1	0	0	0	0	1	0	0	0	2467	1232	43	3	211	3	C9orf163	9	139379109	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	38521882	139379109	1834322	28	12668											
EPC1	80314	broad.mit.edu	37	chr10	32580102	32580102	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attaatcaccttattaacttTgaactccttcacatccattg	2	11	2	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr10:32580102T>C	uc001iwg.1	-	6	1234	c.964A>G	c.(964-966)AAA>GAA	p.K322E	EPC1_uc001iwi.3_Missense_Mutation_p.K272E|EPC1_uc009xlt.2_Missense_Mutation_p.K272E|EPC1_uc001iwh.1_Missense_Mutation_p.K322E	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	322					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)				TTATTAACTTTGAACTCCTTC	0.318													C	32580102	C	C	32580102	3	2	178	1	0	0	0	0	1	0	0	0	5160	1821	63	4	1586	4	EPC1	10	32580102	Missense_Mutation	SNP	T	TCGA-26-5136-01B-01D-1486-08		32580102	102954645	29	12669											
TBC1D12	23232	broad.mit.edu	37	chr10	96163266	96163266	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggggccgccggtgcccttgcCcgccgcggagcagggtcctg	18	16	0	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr10:96163266C>A	uc001kjr.2	+	1	1081	c.896C>A	c.(895-897)CCC>CAC	p.P299H		NM_015188	NP_056003	O60347	TBC12_HUMAN	TBC1 domain family, member 12	299						intracellular	Rab GTPase activator activity				0		Colorectal(252;0.0429)				GTGCCCTTGCCCGCCGCGGAG	0.667													A	96163266	A	A	96163266	3	1	178	1	0	0	0	0	1	0	0	0	15598	623	22	5	898	5	TBC1D12	10	96163266	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	63583164	96163266	39371481	30	12670											
C10orf129	142827	broad.mit.edu	37	chr10	96979715	96979715	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggggaagccattgccacCttatattgtccaggtaggag	12	9	1	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr10:96979715C>T	uc001kke.2	+	9	1312	c.1187C>T	c.(1186-1188)CCT>CTT	p.P396L	C10orf129_uc009xuu.1_Missense_Mutation_p.P306L	NM_207321	NP_997204	Q6P461	ACSM6_HUMAN	acyl-coenzyme A synthetase ACSM6, mitochondrial	396					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CCATTGCCACCTTATATTGTC	0.368													T	96979715	T	T	96979715	3	4	178	1	0	0	0	0	1	0	0	0	1593	681	24	3	1217	3	C10orf129	10	96979715	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	816449	96979715	38555032	31	12671											
DMBT1	1755	broad.mit.edu	37	chr10	124351971	124351971	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcggccccaggaaatgcccGgtttggccagggctcaggac	15	13	1	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr10:124351971G>A	uc001lgk.1	+	20	2466	c.2360G>A	c.(2359-2361)CGG>CAG	p.R787Q	DMBT1_uc001lgl.1_Missense_Mutation_p.R777Q|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Missense_Mutation_p.R787Q|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Missense_Mutation_p.R400Q	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	787	SRCR 6.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGAAATGCCCGGTTTGGCCAG	0.622													A	124351971	A	A	124351971	3	1	178	1	0	0	0	0	1	0	0	0	4577	1116	39	2	2438	2	DMBT1	10	124351971	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	27372256	124351971	11182776	32	12672											
HMX3	340784	broad.mit.edu	37	chr10	124896723	124896723	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tggaggagagcgactccgagGaaagcaaaaaggaaggcgaa	16	6	0	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr10:124896723G>C	uc010quc.1	+	2	550	c.550G>C	c.(550-552)GAA>CAA	p.E184Q		NM_001105574	NP_001099044	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	184					cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		CGACTCCGAGGAAAGCAAAAA	0.677													C	124896723	C	C	124896723	3	2	178	1	0	0	0	0	1	0	0	0	7248	1175	41	5	556	5	HMX3	10	124896723	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	544752	124896723	10638024	33	12673											
PAOX	196743	broad.mit.edu	37	chr10	135197588	135197588	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctggagtttgaggagcccttCtgggagccagactgccagct	14	11	1	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr10:135197588C>A	uc001lmv.2	+	4	1073	c.993C>A	c.(991-993)TTC>TTA	p.F331L	PAOX_uc001lmw.2_Intron|PAOX_uc001lmx.2_Missense_Mutation_p.F331L|PAOX_uc001lmy.2_Intron|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_Intron|PAOX_uc001lnc.2_Intron	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	469					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		AGGAGCCCTTCTGGGAGCCAG	0.587													A	135197588	A	A	135197588	3	1	178	1	0	0	0	0	1	0	0	0	11423	912	32	5	1007	5	PAOX	10	135197588	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	10300865	135197588	337159	34	12674											
PCF11	51585	broad.mit.edu	37	chr11	82878503	82878505	+	In_Frame_Del	DEL	TTG	-	-													aattacacaggatgacttccTtgttgttgtgcatcaaattc							TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr11:82878503_82878505delTTG	uc001ozx.3	+	7	2393_2395	c.2048_2050delTTG	c.(2047-2052)CTTGTT>CTT	p.V686del	PCF11_uc010rsu.1_In_Frame_Del_p.V686del	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	686					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GATGACTTCCTTGTTGTTGTGCA	0.33													-	82878505	-	-	82878503	7	5	178	1	0	1	0	1	0	0	0	0	11573	1609	56	0	2074	0	PCF11	11	82878503	In_Frame_Del	DEL	TTG	TCGA-26-5136-01B-01D-1486-08		82878503	52128013	35	12675											
TRIM49	57093	broad.mit.edu	37	chr11	89531467	89531467	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttgggatatattgcagcataAgtggggaggtggtaaagaga	16	2	0	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr11:89531467A>T	uc001pdb.2	-	8	1519	c.1190T>A	c.(1189-1191)CTT>CAT	p.L397H		NM_020358	NP_065091	P0CI25	TRI49_HUMAN	ring finger protein 18	397	B30.2/SPRY.					intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TTGCAGCATAAGTGGGGAGGT	0.428													T	89531467	T	T	89531467	3	4	178	1	0	0	0	0	1	0	0	0	16521	72	3	5	172	5	TRIM49	11	89531467	Missense_Mutation	SNP	A	TCGA-26-5136-01B-01D-1486-08	6652964	89531467	45475049	36	12676											
ANGPTL5	253935	broad.mit.edu	37	chr11	101762250	101762250	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accaggcatgcagggcgacaCccatcattatcaacatctga	8	13	3	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr11:101762250C>T	uc001pgl.2	-	9	1523	c.927G>A	c.(925-927)GGG>GGA	p.G309G		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	309	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		CAGGGCGACACCCATCATTAT	0.443													T	101762250	T	T	101762250	2	4	178	1	0	0	0	0	0	0	0	1	617	494	18	3		3	ANGPTL5	11	101762250	Silent	SNP	C	TCGA-26-5136-01B-01D-1486-08	12230783	101762250	33244266	37	12677											
TSPAN9	10867	broad.mit.edu	37	chr12	3389625	3389625	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacaacgtggggctgaagaaCgcctggaacatcatccaggc	12	11	1	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr12:3389625C>T	uc001qlp.2	+	6	555	c.408C>T	c.(406-408)AAC>AAT	p.N136N		NM_006675	NP_006666	O75954	TSN9_HUMAN	tetraspanin 9	136	Extracellular (Potential).					integral to plasma membrane|membrane fraction				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			GGCTGAAGAACGCCTGGAACA	0.657													T	3389625	T	T	3389625	2	4	178	1	0	0	0	0	0	0	0	1	16651	535	19	1		1	TSPAN9	12	3389625	Silent	SNP	C	TCGA-26-5136-01B-01D-1486-08		3389625	130462270	38	12678											
PABPC3	5042	broad.mit.edu	37	chr13	25671151	25671151	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctcagaaaaaagtggaacGgcagacggaacttaagcgca	12	8	1	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr13:25671151G>A	uc001upy.2	+	1	876	c.815G>A	c.(814-816)CGG>CAG	p.R272Q		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	272					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAAGTGGAACGGCAGACGGAA	0.398													A	25671151	A	A	25671151	3	1	178	1	0	0	0	0	1	0	0	0	11365	1116	39	2	817	2	PABPC3	13	25671151	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08		25671151	89498727	39	12679											
UGGT2	55757	broad.mit.edu	37	chr13	96530054	96530054	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctgtcactttatcaaagcaTtgtccttccagtagtaagta	6	9	3	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr13:96530054T>C	uc001vmt.2	-	28	3455	c.3285A>G	c.(3283-3285)CAA>CAG	p.Q1095Q	UGGT2_uc001vmu.1_Silent_p.Q182Q	NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	1095					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TATCAAAGCATTGTCCTTCCA	0.403													C	96530054	C	C	96530054	2	2	178	1	0	0	0	0	0	0	0	1	16939	1490	52	4		4	UGGT2	13	96530054	Silent	SNP	T	TCGA-26-5136-01B-01D-1486-08	70858903	96530054	18639824	40	12680											
ADPRHL1	113622	broad.mit.edu	37	chr13	114107590	114107590	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgatggtgttgtcactcaCgggccattctcctggcgaga	12	11	3	2	rs149499588		TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr13:114107590C>T	uc001vtq.1	-	1	250	c.163G>A	c.(163-165)GTG>ATG	p.V55M		NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	55					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			TTGTCACTCACGGGCCATTCT	0.632													T	114107590	T	T	114107590	3	4	178	1	0	0	0	0	1	0	0	0	332	536	19	1	929	1	ADPRHL1	13	114107590	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	17577536	114107590	1062288	41	12681											
PEX11A	8800	broad.mit.edu	37	chr15	90226620	90226620	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaaacaccctaacgggtcttCagcttcatctgaggatatgc	8	11	4	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr15:90226620C>T	uc002boi.2	-	3	827	c.732G>A	c.(730-732)CTG>CTA	p.L244L	PEX11A_uc010upy.1_RNA	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	244	Cytoplasmic (Potential).			KLK->SLS: No effect on peroxisomal location.	cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			AACGGGTCTTCAGCTTCATCT	0.453													T	90226620	T	T	90226620	2	4	178	1	0	0	0	0	0	0	0	1	11737	813	29	3		3	PEX11A	15	90226620	Silent	SNP	C	TCGA-26-5136-01B-01D-1486-08		90226620	12304772	42	12682											
TIGD7	91151	broad.mit.edu	37	chr16	3349388	3349400	+	Frame_Shift_Del	DEL	TTCAGGTTCCTTT	-	-													tctaagccttgaaaatcataTtcaggttcctttttgtaaag							TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr16:3349388_3349400delTTCAGGTTCCTTT	uc002cus.2	-	1	2001_2013	c.1215_1227delAAAGGAACCTGAA	c.(1213-1227)AAAAAGGAACCTGAAfs	p.K405fs	ZNF263_uc002cur.2_3'UTR	NM_033208	NP_149985	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	405_409					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						GAAAATCATATTCAGGTTCCTTTTTGTAAAGAA	0.329													-	3349400	-	-	3349388	7	5	178	1	0	1	0	1	0	0	0	0	15898	1490	52	0	426	0	TIGD7	16	3349388	Frame_Shift_Del	DEL	TTCAGGTTCCTTT	TCGA-26-5136-01B-01D-1486-08		3349388	87005365	43	12683											
CDH5	1003	broad.mit.edu	37	chr16	66429972	66429972	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgggcagatactccatcCgcaggaccagtgacaagggc	12	14	0	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr16:66429972C>T	uc002eom.3	+	8	1384	c.1228C>T	c.(1228-1230)CGC>TGC	p.R410C		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	410	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		ATACTCCATCCGCAGGACCAG	0.493													T	66429972	T	T	66429972	3	4	178	1	0	0	0	0	1	0	0	0	3113	652	23	2	1254	2	CDH5	16	66429972	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	63080584	66429972	23924781	44	12684											
CDH15	1013	broad.mit.edu	37	chr16	89251737	89251737	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgcaagtggggctggaccGcgaggtgaggtggcgccccg	20	10	0	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr16:89251737G>A	uc002fmt.2	+	5	736	c.659G>A	c.(658-660)CGC>CAC	p.R220H	CDH15_uc010cij.1_Missense_Mutation_p.R220H	NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	220	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGGCTGGACCGCGAGGTGAGG	0.706													A	89251737	A	A	89251737	3	1	178	1	0	0	0	0	1	0	0	0	3100	1087	38	1	677	1	CDH15	16	89251737	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	22821765	89251737	1103016	45	12685											
TP53	7157	broad.mit.edu	37	chr17	7578534	7578534	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ttggccagttggcaaaacatCttgttgagggcaggggagta	15	6	1	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr17:7578534C>A	uc002gim.2	-	5	590	c.396G>T	c.(394-396)AAG>AAT	p.K132N	TP53_uc002gig.1_Missense_Mutation_p.K132N|TP53_uc002gih.2_Missense_Mutation_p.K132N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.K132N|TP53_uc010cni.1_Missense_Mutation_p.K132N|TP53_uc002gij.2_Missense_Mutation_p.K132N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.K39N|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.K93N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	132	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> T (in sporadic cancers; somatic mutation).|KM -> NL (in a sporadic cancer; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> R (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> Q (in sporadic cancers; somatic mutation).|K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(40)|p.K132R(32)|p.K132E(19)|p.K132Q(13)|p.K132M(9)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.K132T(4)|p.K132*(2)|p.N131fs*27(2)|p.K132fs*38(2)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.M133fs*16(1)|p.V73fs*9(1)|p.A129_K132delALNK(1)|p.L130_M133delLNKM(1)|p.M133fs*37(1)|p.K132_A138delKMFCQLA(1)|p.S127fs*36(1)|p.K132K(1)|p.K132W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAAAACATCTTGTTGAGGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578534	A	A	7578534	3	1	178	1	0	0	0	0	1	0	0	0	16378	912	32	5	902	5	TP53	17	7578534	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08		7578534	73616676	46	12686											
PHF12	57649	broad.mit.edu	37	chr17	27240145	27240145	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtaggtgtcttgtcagctgTttgcagggaggtggtgactg	17	5	2	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr17:27240145T>C	uc002hdg.1	-	9	1974	c.1444A>G	c.(1444-1446)ACA>GCA	p.T482A	PHF12_uc010wbb.1_Missense_Mutation_p.T464A|PHF12_uc002hdi.1_Missense_Mutation_p.T478A|PHF12_uc002hdj.1_Missense_Mutation_p.T482A|PHF12_uc010crw.1_Missense_Mutation_p.T185A|PHF12_uc002hdh.1_Missense_Mutation_p.T265A	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	482	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TTGTCAGCTGTTTGCAGGGAG	0.542													C	27240145	C	C	27240145	3	2	178	1	0	0	0	0	1	0	0	0	11823	1725	60	4	1624	4	PHF12	17	27240145	Missense_Mutation	SNP	T	TCGA-26-5136-01B-01D-1486-08	19661611	27240145	53955065	47	12687											
KIF18B	146909	broad.mit.edu	37	chr17	43005601	43005601	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttttgatgactgtggctgggCaaacgcgaggggaatggcag	17	6	0	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr17:43005601C>G	uc010wji.1	-	13	2179	c.2078G>C	c.(2077-2079)TGC>TCC	p.C693S	KIF18B_uc002iht.2_Missense_Mutation_p.C702S|KIF18B_uc010wjh.1_Missense_Mutation_p.C690S	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				TGTGGCTGGGCAAACGCGAGG	0.647													G	43005601	G	G	43005601	3	3	178	1	0	0	0	0	1	0	0	0	8281	710	25	5	504	5	KIF18B	17	43005601	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	15765456	43005601	38189609	48	12688											
EPB41L3	23136	broad.mit.edu	37	chr18	5415838	5415838	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcttcctctgaactgtcactCgggtcattgtctagggaggc	11	11	5	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr18:5415838C>T	uc002kmt.1	-	13	2132	c.2046G>A	c.(2044-2046)CCG>CCA	p.P682P	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Intron|EPB41L3_uc010wzf.1_Intron|EPB41L3_uc010wzg.1_Intron|EPB41L3_uc010dkr.2_Intron	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	682	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						AACTGTCACTCGGGTCATTGT	0.582													T	5415838	T	T	5415838	2	4	178	1	0	0	0	0	0	0	0	1	5154	871	31	2		2	EPB41L3	18	5415838	Silent	SNP	C	TCGA-26-5136-01B-01D-1486-08		5415838	72661410	49	12689											
KIAA0802	23255	broad.mit.edu	37	chr18	8786006	8786020	+	In_Frame_Del	DEL	CGAGCCGCGCGGGAG	-	-													agcgggagagcctgcgcctcCgagccgcgcgggagctgcac							TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr18:8786006_8786020delCGAGCCGCGCGGGAG	uc002knr.2	+	7	1946_1960	c.1804_1818delCGAGCCGCGCGGGAG	c.(1804-1818)CGAGCCGCGCGGGAGdel	p.RAARE602del	KIAA0802_uc002knq.2_In_Frame_Del_p.RAARE602del|KIAA0802_uc010dkw.1_In_Frame_Del_p.RAARE440del	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	953_957											0						CCTGCGCCTCCGAGCCGCGCGGGAGCTGCACCGCC	0.707													-	8786020	-	-	8786006	7	5	178	1	0	1	0	1	0	0	0	0	8194	644	23	0	1822	0	KIAA0802	18	8786006	In_Frame_Del	DEL	CGAGCCGCGCGGGAG	TCGA-26-5136-01B-01D-1486-08	3370168	8786006	69291242	50	12690											
NWD1	284434	broad.mit.edu	37	chr19	16860196	16860196	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaccgcctgccgtggagccGcgacttggtgaaccccaaga	12	16	0	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr19:16860196G>A	uc002neu.3	+	6	1165	c.743G>A	c.(742-744)CGC>CAC	p.R248H	NWD1_uc002net.3_Missense_Mutation_p.R113H|NWD1_uc002nev.3_Missense_Mutation_p.R42H			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	248							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CCGTGGAGCCGCGACTTGGTG	0.597													A	16860196	A	A	16860196	3	1	178	1	0	0	0	0	1	0	0	0	10781	1087	38	1	344	1	NWD1	19	16860196	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08		16860196	42268787	51	12691											
MAST3	23031	broad.mit.edu	37	chr19	18218415	18218415	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaaggagctgagcctgccaCgccgaggacgtgggtgagtt	17	9	0	3			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr19:18218415C>T	uc002nhz.3	+	2	58	c.58C>T	c.(58-60)CGC>TGC	p.R20C		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	20							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GAGCCTGCCACGCCGAGGACG	0.572													T	18218415	T	T	18218415	3	4	178	1	0	0	0	0	1	0	0	0	9326	536	19	1	64	1	MAST3	19	18218415	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	1358219	18218415	40910568	52	12692											
MLL4	9757	broad.mit.edu	37	chr19	36224327	36224327	+	Frame_Shift_Del	DEL	C	-	-													gccggtccccgccagcacctCccccatacaaagccccccgg							TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr19:36224327delC	uc010eei.2	+	29	6877	c.6877delC	c.(6877-6879)CCCfs	p.P2293fs		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2293					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCCAGCACCTCCCCCATACAA	0.682													-	36224327	-	-	36224327	7	5	178	1	0	1	0	1	0	0	0	0	9623	855	30	0	6987	0	MLL4	19	36224327	Frame_Shift_Del	DEL	C	TCGA-26-5136-01B-01D-1486-08	18005912	36224327	22904656	53	12693											
CD33	945	broad.mit.edu	37	chr19	51742917	51742917	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttccaaggacacctccaccGaatactcagaggtcaggacc	8	15	2	1	rs148758925	byFrequency	TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr19:51742917G>A	uc002pwa.2	+	7	1109	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K	CD33_uc010eos.1_3'UTR|CD33_uc010eot.1_Missense_Mutation_p.E230K|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	357	ITIM motif 2.|Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CACCTCCACCGAATACTCAGA	0.527													A	51742917	A	A	51742917	3	1	178	1	0	0	0	0	1	0	0	0	3005	1059	37	2	1108	2	CD33	19	51742917	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	15518590	51742917	7386066	54	12694											
MBOAT7	79143	broad.mit.edu	37	chr19	54677935	54677935	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gaagcccatgcacatgtagtCataggcgcgcatcttcagga	11	11	3	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr19:54677935C>G	uc002qdq.2	-	9	1488	c.1222G>C	c.(1222-1224)GAC>CAC	p.D408H	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Missense_Mutation_p.D92H|MBOAT7_uc010yem.1_Missense_Mutation_p.D390H|MBOAT7_uc002qdr.2_Missense_Mutation_p.D408H|MBOAT7_uc002qds.2_Missense_Mutation_p.D335H|MBOAT7_uc010yen.1_Missense_Mutation_p.D335H	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	408					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CACATGTAGTCATAGGCGCGC	0.652													G	54677935	G	G	54677935	3	3	178	1	0	0	0	0	1	0	0	0	9358	826	29	5	200	5	MBOAT7	19	54677935	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	2935018	54677935	4451048	55	12695											
SAMHD1	25939	broad.mit.edu	37	chr20	35547889	35547889	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aattccattagaattaataaGgtgctcaaacatcataactg	5	7	2	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chr20:35547889G>A	uc002xgh.1	-	7	860	c.730C>T	c.(730-732)CTT>TTT	p.L244F		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	244	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				GAATTAATAAGGTGCTCAAAC	0.368													A	35547889	A	A	35547889	3	1	178	1	0	0	0	0	1	0	0	0	13828	1000	35	3	1190	3	SAMHD1	20	35547889	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08		35547889	27477631	56	12696											
PRKX	5613	broad.mit.edu	37	chrX	3573336	3573336	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cagatgatctctgcagagtaGaagagccccgtggtgctgga	14	9	1	5			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:3573336G>C	uc010nde.2	-	3	820	c.453C>G	c.(451-453)TTC>TTG	p.F151L		NM_005044	NP_005035	P51817	PRKX_HUMAN	protein kinase, X-linked	151	Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			skin(2)|lung(1)	3		all_lung(23;0.000396)|Lung NSC(23;0.00123)				CTGCAGAGTAGAAGAGCCCCG	0.587													C	3573336	C	C	3573336	3	2	178	1	0	0	0	0	1	0	0	0	12527	933	33	5	647	5	PRKX	23	3573336	Missense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08		3573336	151697224	57	12697											
MSL3	10943	broad.mit.edu	37	chrX	11790274	11790274	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaattcgtgctttttccaGgtcctctcctggaagcttgt	8	11	2	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:11790274G>A	uc004cuw.2	+	11	1387	c.1282_splice	c.e11-1	p.V428_splice	MSL3_uc004cux.2_Splice_Site_p.V369_splice|MSL3_uc011mig.1_Splice_Site_p.V279_splice|MSL3_uc011mih.1_Splice_Site_p.V416_splice|MSL3_uc004cuy.2_Splice_Site_p.V262_splice	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a						histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCTTTTTCCAGGTCCTCTCCT	0.443													A	11790274	A	A	11790274	5	1	178	1	0	0	0	0	0	0	1	0	9879	1014	35	3	1403	3	MSL3	23	11790274	Splice_Site	SNP	G	TCGA-26-5136-01B-01D-1486-08	8216938	11790274	143480286	58	12698											
XK	7504	broad.mit.edu	37	chrX	37545375	37545375	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgcgcgctcgtgcagctcaCgcttctcttcgtacaccgcg	10	16	2	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:37545375C>T	uc004ddq.2	+	1	243	c.161C>T	c.(160-162)ACG>ATG	p.T54M		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	54	Helical; (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				GTGCAGCTCACGCTTCTCTTC	0.662													T	37545375	T	T	37545375	3	4	178	1	0	0	0	0	1	0	0	0	17428	536	19	1	163	1	XK	23	37545375	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	25755101	37545375	117725185	59	12699											
UBA1	7317	broad.mit.edu	37	chrX	47069360	47069360	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtggagcgaacactgcggctGgcaggcactcagcccttgga	15	12	1	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:47069360G>C	uc004dhj.3	+	18	2188	c.2037G>C	c.(2035-2037)CTG>CTC	p.L679L	UBA1_uc004dhk.3_Silent_p.L679L|UBA1_uc004dhm.2_Silent_p.L127L	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	679					cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						CACTGCGGCTGGCAGGCACTC	0.607													C	47069360	C	C	47069360	2	2	178	1	0	0	0	0	0	0	0	1	16824	1335	47	5		5	UBA1	23	47069360	Silent	SNP	G	TCGA-26-5136-01B-01D-1486-08	9523985	47069360	108201200	60	12700											
OTUD5	55593	broad.mit.edu	37	chrX	48814296	48814296	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcagccgcctcatactcGtcctcactgttgtagcctgc	9	16	2	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:48814296G>A	uc004dlu.2	-	1	598	c.537C>T	c.(535-537)GAC>GAT	p.D179D	OTUD5_uc004dlt.3_Silent_p.D179D|OTUD5_uc004dlv.2_Silent_p.D179D|OTUD5_uc011mmp.1_Intron	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	179					negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						CCTCATACTCGTCCTCACTGT	0.677													A	48814296	A	A	48814296	2	1	178	1	0	0	0	0	0	0	0	1	11315	1136	40	1		1	OTUD5	23	48814296	Silent	SNP	G	TCGA-26-5136-01B-01D-1486-08	1744936	48814296	106456264	61	12701											
TEX11	56159	broad.mit.edu	37	chrX	69871358	69871358	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atataaaattgagtgaaaacGttcctagggtcatgtcgttc	9	6	1	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:69871358G>A	uc004dyl.2	-	18	1632	c.1470C>T	c.(1468-1470)AAC>AAT	p.N490N	TEX11_uc004dyk.2_Silent_p.N165N|TEX11_uc004dym.2_Silent_p.N475N	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	490							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					GAGTGAAAACGTTCCTAGGGT	0.358													A	69871358	A	A	69871358	2	1	178	1	0	0	0	0	0	0	0	1	15771	1136	40	1		1	TEX11	23	69871358	Silent	SNP	G	TCGA-26-5136-01B-01D-1486-08	21057062	69871358	85399202	62	12702											
CXorf57	55086	broad.mit.edu	37	chrX	105855567	105855567	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaggatgagccacgcgacaCggtgcccaagcctccccttt	11	15	0	2			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:105855567C>T	uc004emi.3	+	1	408	c.257C>T	c.(256-258)ACG>ATG	p.T86M	CXorf57_uc004emj.3_Missense_Mutation_p.T86M|CXorf57_uc004emh.2_Missense_Mutation_p.T86M	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	86										ovary(1)|lung(1)|breast(1)	3						CCACGCGACACGGTGCCCAAG	0.557													T	105855567	T	T	105855567	3	4	178	1	0	0	0	0	1	0	0	0	4113	536	19	1	259	1	CXorf57	23	105855567	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	35984209	105855567	49414993	63	12703											
TMEM164	84187	broad.mit.edu	37	chrX	109247264	109247264	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agcggccagaggaaggcaagGagagcctgagcaagaatctg	16	8	1	4			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:109247264G>T	uc004eom.2	+	2	581	c.262G>T	c.(262-264)GAG>TAG	p.E88*	TMEM164_uc004eol.2_Intron|TMEM164_uc010npq.2_Nonsense_Mutation_p.E88*	NM_032227	NP_115603	Q5U3C3	TM164_HUMAN	transmembrane protein 164 isoform b	88						integral to membrane				large_intestine(1)|lung(1)|skin(1)	3						GGAAGGCAAGGAGAGCCTGAG	0.617													T	109247264	T	T	109247264	4	4	178	1	0	0	0	0	0	1	0	0	16076	1175	41	5	264	5	TMEM164	23	109247264	Nonsense_Mutation	SNP	G	TCGA-26-5136-01B-01D-1486-08	3391697	109247264	46023296	64	12704											
TREX2	11219	broad.mit.edu	37	chrX	152710600	152710600	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcctgcagcgtccgcaccaCggcgccatcaaagccagcct	11	18	1	0			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:152710600C>T	uc010nue.1	-	3	531	c.415G>A	c.(415-417)GTG>ATG	p.V139M	TREX2_uc010nud.1_Missense_Mutation_p.V97M|TREX2_uc011myp.1_Missense_Mutation_p.V97M|HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA	NM_080701	NP_542432	Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	140					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			large_intestine(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTCCGCACCACGGCGCCATCA	0.657								Editing_and_processing_nucleases					T	152710600	T	T	152710600	3	4	178	1	0	0	0	0	1	0	0	0	16474	536	19	1	424	1	TREX2	23	152710600	Missense_Mutation	SNP	C	TCGA-26-5136-01B-01D-1486-08	43463336	152710600	2559960	65	12705											
ATP2B3	492	broad.mit.edu	37	chrX	152830482	152830482	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggagctggccgaaggcgaggAagagatcgaccatgccgagc	17	10	0	1			TCGA-26-5136-01B-01D-1486-08	TCGA-26-5136-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	39e0587b-1b04-4c68-8ae4-3ae7781e8017	744f1805-ff88-4a74-b098-a00c74bce072	g.chrX:152830482A>T	uc004fht.1	+	19	3389	c.3263A>T	c.(3262-3264)GAA>GTA	p.E1088V	ATP2B3_uc004fhs.1_Missense_Mutation_p.E1088V|ATP2B3_uc010nuf.1_Missense_Mutation_p.E111V|ATP2B3_uc004fhu.1_Missense_Mutation_p.E11V	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	1088	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAAGGCGAGGAAGAGATCGAC	0.662													T	152830482	T	T	152830482	3	4	178	1	0	0	0	0	1	0	0	0	1141	246	9	5	3337	5	ATP2B3	23	152830482	Missense_Mutation	SNP	A	TCGA-26-5136-01B-01D-1486-08	119882	152830482	2440078	66	12706											
VPS72	6944	broad.mit.edu	37	chr1	151149180	151149180	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gagccagggaggggctcaggAggtggcgggccggggcccag	23	10	1	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr1:151149180A>T	uc001exe.1	-	6	1078	c.1035T>A	c.(1033-1035)CCT>CCA	p.P345P	TMOD4_uc001exd.2_5'Flank|TMOD4_uc001exc.3_5'Flank|TMOD4_uc010pct.1_5'Flank	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	345	Poly-Pro.|Pro-rich.				chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGGGCTCAGGAGGTGGCGGGC	0.572													T	151149180	T	T	151149180	2	4	179	1	0	0	0	0	0	0	0	1	17214	291	11	5		5	VPS72	1	151149180	Silent	SNP	A	TCGA-26-5139-01A-01D-1486-08		151149180	98101441	1	12707											
YY1AP1	55249	broad.mit.edu	37	chr1	155646478	155646478	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttcatcttcagctgttcaAatagttccttcgctatctga	5	11	6	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr1:155646478A>G	uc001fln.2	-	5	407	c.383T>C	c.(382-384)TTT>TCT	p.F128S	YY1AP1_uc010pgg.1_5'UTR|YY1AP1_uc010pgh.1_Missense_Mutation_p.F51S|YY1AP1_uc010pgi.1_Missense_Mutation_p.F200S|YY1AP1_uc001flh.2_Missense_Mutation_p.F200S|YY1AP1_uc009wqt.2_Missense_Mutation_p.F51S|YY1AP1_uc001flk.2_Missense_Mutation_p.F51S|YY1AP1_uc001fll.2_Missense_Mutation_p.F62S|YY1AP1_uc009wqv.2_5'UTR|YY1AP1_uc001flm.2_Missense_Mutation_p.F51S|YY1AP1_uc001fli.2_Missense_Mutation_p.F62S|YY1AP1_uc009wqu.2_5'UTR|YY1AP1_uc001flj.2_Missense_Mutation_p.F62S|YY1AP1_uc009wqw.2_Missense_Mutation_p.F51S|YY1AP1_uc001flo.2_5'UTR|YY1AP1_uc001flp.2_Missense_Mutation_p.F62S|YY1AP1_uc010pgj.1_Missense_Mutation_p.F128S|YY1AP1_uc009wqx.2_Missense_Mutation_p.F200S|YY1AP1_uc010pgk.1_Missense_Mutation_p.F200S	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	128					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CAGCTGTTCAAATAGTTCCTT	0.438													G	155646478	G	G	155646478	3	3	179	1	0	0	0	0	1	0	0	0	17505	14	1	4	2095	4	YY1AP1	1	155646478	Missense_Mutation	SNP	A	TCGA-26-5139-01A-01D-1486-08	4497298	155646478	93604143	2	12708											
PEAR1	375033	broad.mit.edu	37	chr1	156875138	156875138	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtataccggaccgtgtacCgtcaggtggtgaagacggac	14	9	1	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr1:156875138C>T	uc001fqj.1	+	4	345	c.229C>T	c.(229-231)CGT>TGT	p.R77C	PEAR1_uc009wsl.1_5'Flank|PEAR1_uc001fqk.1_5'Flank	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	77	EMI.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GACCGTGTACCGTCAGGTGGT	0.657													T	156875138	T	T	156875138	3	4	179	1	0	0	0	0	1	0	0	0	11712	652	23	2	239	2	PEAR1	1	156875138	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08	1228660	156875138	92375483	3	12709											
CD5L	922	broad.mit.edu	37	chr1	157804444	157804444	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcacacggtataccactgGttctggtgcttcacttccac	9	13	2	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr1:157804444G>A	uc001frk.3	-	4	614	c.471C>T	c.(469-471)AAC>AAT	p.N157N		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	157	SRCR 2.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TATACCACTGGTTCTGGTGCT	0.622													A	157804444	A	A	157804444	2	1	179	1	0	0	0	0	0	0	0	1	3027	1252	44	3		3	CD5L	1	157804444	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	929306	157804444	91446177	4	12710											
MYT1L	23040	broad.mit.edu	37	chr2	1926965	1926965	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatcgtaattgtcatattcGtcattattgttatcatcctt	4	8	4	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr2:1926965G>A	uc002qxe.2	-	10	1403	c.576C>T	c.(574-576)GAC>GAT	p.D192D	MYT1L_uc002qxd.2_Silent_p.D192D|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	192					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TGTCATATTCGTCATTATTGT	0.368													A	1926965	A	A	1926965	2	1	179	1	0	0	0	0	0	0	0	1	10107	1136	40	1		1	MYT1L	2	1926965	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08		1926965	241272408	5	12711											
XDH	7498	broad.mit.edu	37	chr2	31620554	31620554	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctggcaaaggtccggaagcCctggaggatgggtctgtagc	16	10	1	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr2:31620554C>A	uc002rnv.1	-	6	554	c.475G>T	c.(475-477)GGC>TGC	p.G159C		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	159					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GTCCGGAAGCCCTGGAGGATG	0.552													A	31620554	A	A	31620554	3	1	179	1	0	0	0	0	1	0	0	0	17423	623	22	5	3650	5	XDH	2	31620554	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08	29693589	31620554	211578819	6	12712											
CHL1	10752	broad.mit.edu	37	chr3	440026	440026	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgactaagaattggggcgatAatgatagcatttttcaagat	10	4	1	4			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr3:440026A>T	uc003bou.2	+	24	3434	c.3163A>T	c.(3163-3165)AAT>TAT	p.N1055Y	CHL1_uc003bot.2_Missense_Mutation_p.N1071Y|CHL1_uc003bow.1_Missense_Mutation_p.N1055Y|CHL1_uc011asi.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1055	Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTGGGGCGATAATGATAGCAT	0.383													T	440026	T	T	440026	3	4	179	1	0	0	0	0	1	0	0	0	3349	362	13	5	3301	5	CHL1	3	440026	Missense_Mutation	SNP	A	TCGA-26-5139-01A-01D-1486-08		440026	197582404	7	12713											
FGD5	152273	broad.mit.edu	37	chr3	14861539	14861539	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accatgcacaggatgagtccGccgaggagagctgccagatt	13	11	0	3			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr3:14861539G>A	uc003bzc.2	+	1	1071	c.961G>A	c.(961-963)GCC>ACC	p.A321T	FGD5_uc011avk.1_Missense_Mutation_p.A321T	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	321	Glu-rich.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						GGATGAGTCCGCCGAGGAGAG	0.552													A	14861539	A	A	14861539	3	1	179	1	0	0	0	0	1	0	0	0	5836	1087	38	1	963	1	FGD5	3	14861539	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	14421513	14861539	183160891	8	12714											
VILL	50853	broad.mit.edu	37	chr3	38035909	38035909	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtgctgcaccgcgaggcgcAgggccacgagtccgactgct	15	15	0	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr3:38035909A>G	uc003chj.2	+	4	579	c.293A>G	c.(292-294)CAG>CGG	p.Q98R	VILL_uc003chk.1_Missense_Mutation_p.Q98R|VILL_uc003chl.2_Missense_Mutation_p.Q98R|VILL_uc010hgu.2_5'UTR	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	98					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CGCGAGGCGCAGGGCCACGAG	0.721													G	38035909	G	G	38035909	3	3	179	1	0	0	0	0	1	0	0	0	17162	188	7	4	303	4	VILL	3	38035909	Missense_Mutation	SNP	A	TCGA-26-5139-01A-01D-1486-08	23174370	38035909	159986521	9	12715											
NPRL2	10641	broad.mit.edu	37	chr3	50385755	50385755	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacccaccactaccttgcttGgtcacgtaggatagacatgc	8	13	1	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr3:50385755G>A	uc003daj.1	-	8	1210	c.807C>T	c.(805-807)ACC>ACT	p.T269T	ZMYND10_uc003dag.1_5'Flank|ZMYND10_uc010hll.1_5'Flank|ZMYND10_uc003dah.1_5'Flank|ZMYND10_uc010hlm.1_5'Flank|NPRL2_uc003dai.1_Silent_p.T149T|CYB561D2_uc003dak.2_5'Flank|CYB561D2_uc003dal.2_5'Flank|CYB561D2_uc003dam.2_5'Flank	NM_006545	NP_006536	Q8WTW4	NPRL2_HUMAN	tumor suppressor candidate 4	269					negative regulation of kinase activity		protein binding|protein kinase activity			lung(1)	1						TACCTTGCTTGGTCACGTAGG	0.577													A	50385755	A	A	50385755	2	1	179	1	0	0	0	0	0	0	0	1	10597	1335	47	3		3	NPRL2	3	50385755	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	12349846	50385755	147636675	10	12716											
STXBP5L	9515	broad.mit.edu	37	chr3	120833881	120833881	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcattctttctggatatgttAtcatgtggaacaaggcaatt	8	6	4	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr3:120833881A>G	uc003eec.3	+	6	720	c.580A>G	c.(580-582)ATC>GTC	p.I194V	STXBP5L_uc011bji.1_Missense_Mutation_p.I194V	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	194	WD 3.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TGGATATGTTATCATGTGGAA	0.318													G	120833881	G	G	120833881	3	3	179	1	0	0	0	0	1	0	0	0	15356	449	16	4	598	4	STXBP5L	3	120833881	Missense_Mutation	SNP	A	TCGA-26-5139-01A-01D-1486-08	70448126	120833881	77188549	11	12717											
SI	6476	broad.mit.edu	37	chr3	164730787	164730787	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattaacagcttcatcttccGttagagttttatctattgtt	5	8	3	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr3:164730787G>A	uc003fei.2	-	34	4105	c.4043C>T	c.(4042-4044)ACG>ATG	p.T1348M		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1348	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTCATCTTCCGTTAGAGTTTT	0.323										HNSCC(35;0.089)			A	164730787	A	A	164730787	3	1	179	1	0	0	0	0	1	0	0	0	14297	1145	40	1	1500	1	SI	3	164730787	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	43896906	164730787	33291643	12	12718											
DGKQ	1609	broad.mit.edu	37	chr4	956666	956666	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acagtgccatcgccaccacaCaccagcacccggaagcaggg	10	17	0	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr4:956666C>A	uc003gbw.2	-	17	2003	c.1929G>T	c.(1927-1929)GTG>GTT	p.V643V	DGKQ_uc010ibn.2_Silent_p.V630V	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	643	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CGCCACCACACACCAGCACCC	0.682													A	956666	A	A	956666	2	1	179	1	0	0	0	0	0	0	0	1	4473	465	17	5		5	DGKQ	4	956666	Silent	SNP	C	TCGA-26-5139-01A-01D-1486-08		956666	190197610	13	12719											
PRKG2	5593	broad.mit.edu	37	chr4	82056416	82056416	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcttctgtcacacaagcaaCgcagaatttggaggtgggtt	12	8	2	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr4:82056416C>T	uc003hmh.2	-	13	1683	c.1669G>A	c.(1669-1671)GTT>ATT	p.V557I	PRKG2_uc011ccf.1_Missense_Mutation_p.V137I|PRKG2_uc011ccg.1_Missense_Mutation_p.V137I|PRKG2_uc011cch.1_Missense_Mutation_p.V528I	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	557	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						ACACAAGCAACGCAGAATTTG	0.413													T	82056416	T	T	82056416	3	4	179	1	0	0	0	0	1	0	0	0	12523	536	19	1	643	1	PRKG2	4	82056416	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08	81099750	82056416	109097860	14	12720											
FAT4	79633	broad.mit.edu	37	chr4	126372061	126372061	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacaaatgaatatgtgccccGttttgtttccaaactttact	6	9	0	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr4:126372061G>A	uc003ifj.3	+	9	9890	c.9890G>A	c.(9889-9891)CGT>CAT	p.R3297H	FAT4_uc011cgp.1_Missense_Mutation_p.R1595H|FAT4_uc003ifi.1_Missense_Mutation_p.R775H	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3297	Cadherin 31.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TATGTGCCCCGTTTTGTTTCC	0.403													A	126372061	A	A	126372061	3	1	179	1	0	0	0	0	1	0	0	0	5692	1145	40	1	9924	1	FAT4	4	126372061	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	44315645	126372061	64782215	15	12721											
DCHS2	54798	broad.mit.edu	37	chr4	155241880	155241880	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gggtggatgagaaatggattCgtgccagggttgtgggattc	18	4	0	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr4:155241880C>T	uc003inw.2	-	14	3306	c.3306G>A	c.(3304-3306)ACG>ACA	p.T1102T		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1102	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAAATGGATTCGTGCCAGGGT	0.453													T	155241880	T	T	155241880	2	4	179	1	0	0	0	0	0	0	0	1	4288	871	31	2		2	DCHS2	4	155241880	Silent	SNP	C	TCGA-26-5139-01A-01D-1486-08	28869819	155241880	35912396	16	12722											
KIAA1430	57587	broad.mit.edu	37	chr4	186111564	186111564	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaagactgaagagggctaaTgtctggagttgataagggac	14	4	1	4			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr4:186111564T>C	uc003ixf.3	-	2	934	c.787A>G	c.(787-789)ATT>GTT	p.I263V	KIAA1430_uc003ixg.2_Missense_Mutation_p.I263V	NM_020827	NP_065878	Q9P2B7	K1430_HUMAN	hypothetical protein LOC57587	263											0		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		AGAGGGCTAATGTCTGGAGTT	0.398													C	186111564	C	C	186111564	3	2	179	1	0	0	0	0	1	0	0	0	8232	1464	51	4	827	4	KIAA1430	4	186111564	Missense_Mutation	SNP	T	TCGA-26-5139-01A-01D-1486-08	30869684	186111564	5042712	17	12723											
TUBB4Q	56604	broad.mit.edu	37	chr4	190904404	190904404	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaggtctcatctgcgttttcTatgagctggtggactgagag	13	7	3	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr4:190904404T>C	uc011clg.1	-	4	579	c.576A>G	c.(574-576)ATA>ATG	p.I192M		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	193					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		CTGCGTTTTCTATGAGCTGGT	0.507													C	190904404	C	C	190904404	3	2	179	1	0	0	0	0	1	0	0	0	16756	1512	53	4	728	4	TUBB4Q	4	190904404	Missense_Mutation	SNP	T	TCGA-26-5139-01A-01D-1486-08	4792840	190904404	249872	18	12724											
CDH18	1016	broad.mit.edu	37	chr5	19544032	19544032	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tggagtttcttctctgtcgaGaacctttgtagtcctaatgg	10	8	2	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr5:19544032G>A	uc003jgc.2	-	8	1713	c.1336C>T	c.(1336-1338)CTC>TTC	p.L446F	CDH18_uc003jgd.2_Missense_Mutation_p.L446F|CDH18_uc011cnm.1_Missense_Mutation_p.L446F	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	446	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TCTCTGTCGAGAACCTTTGTA	0.363													A	19544032	A	A	19544032	3	1	179	1	0	0	0	0	1	0	0	0	3103	942	33	3	1056	3	CDH18	5	19544032	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08		19544032	161371228	19	12725											
PIK3R1	5295	broad.mit.edu	37	chr5	67591247	67591249	+	Splice_Site	DEL	GGT	-	-													cttttcaaaactgtttttcaGgtggttgactcaaaaaggtg							TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr5:67591247_67591249delGGT	uc003jva.2	+	14	2306	c.1746_splice	c.e14-1	p.M582_splice	PIK3R1_uc003jvb.2_Splice_Site_p.M582_splice|PIK3R1_uc003jvc.2_Splice_Site_p.M282_splice|PIK3R1_uc003jvd.2_Splice_Site_p.M312_splice|PIK3R1_uc003jve.2_Splice_Site_p.M261_splice|PIK3R1_uc011crb.1_Splice_Site_p.M252_splice	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.M582_D605>I(4)|p.?(3)|p.Y580fs*1(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CTGTTTTTCAGGTGGTTGACTCA	0.365			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67591249	-	-	67591247	8	5	179	1	0	1	0	1	0	0	1	0	11918	1014	35	0	1925	0	PIK3R1	5	67591247	Splice_Site	DEL	GGT	TCGA-26-5139-01A-01D-1486-08	48047215	67591247	113324013	20	12726											
CDK7	1022	broad.mit.edu	37	chr5	68555711	68555711	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactggcagattttggcctgGccaaatcttttgggagcccc	11	11	1	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr5:68555711G>A	uc003jvs.3	+	7	656	c.475G>A	c.(475-477)GCC>ACC	p.A159T	CDK7_uc003jvt.3_Missense_Mutation_p.A118T|CDK7_uc003jvu.3_Missense_Mutation_p.A66T	NM_001799	NP_001790	P50613	CDK7_HUMAN	cyclin-dependent kinase 7	159	Protein kinase.				androgen receptor signaling pathway|cell division|cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex|mitochondrion	androgen receptor binding|ATP binding|cyclin-dependent protein kinase activity|DNA-dependent ATPase activity|protein C-terminus binding|RNA polymerase II carboxy-terminal domain kinase activity|transcription coactivator activity			lung(1)	1		Lung NSC(167;7.26e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.98e-56)|Epithelial(20;3.54e-52)|all cancers(19;9.11e-48)|Lung(70;0.0185)		TTTTGGCCTGGCCAAATCTTT	0.388								NER					A	68555711	A	A	68555711	3	1	179	1	0	0	0	0	1	0	0	0	3149	1203	42	3	501	3	CDK7	5	68555711	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	964464	68555711	112359549	21	12727											
FAM13B	51306	broad.mit.edu	37	chr5	137275998	137275998	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attttcttgtactctctgtaCtcctcaagcactggaacacg	6	12	3	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr5:137275998C>T	uc003lbz.2	-	23	3198	c.2664G>A	c.(2662-2664)GAG>GAA	p.E888E	FAM13B_uc003lcb.2_Silent_p.E764E|FAM13B_uc003lca.2_Silent_p.E860E|PKD2L2_uc003lbw.1_3'UTR|PKD2L2_uc003lbx.2_3'UTR|PKD2L2_uc003lby.2_Intron|PKD2L2_uc011cyi.1_3'UTR	NM_016603	NP_057687	Q9NYF5	FA13B_HUMAN	hypothetical protein LOC51306 isoform 1	888					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						ACTCTCTGTACTCCTCAAGCA	0.353													T	137275998	T	T	137275998	2	4	179	1	0	0	0	0	0	0	0	1	5453	564	20	3		3	FAM13B	5	137275998	Silent	SNP	C	TCGA-26-5139-01A-01D-1486-08	68720287	137275998	43639262	22	12728											
PREP	5550	broad.mit.edu	37	chr6	105800946	105800946	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	caagacatagcggccatcatCagataactaaaaaagaaaaa	6	8	2	3			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr6:105800946C>T	uc003prc.2	-	7	927	c.724G>A	c.(724-726)GAT>AAT	p.D242N		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	242					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	CGGCCATCATCAGATAACTAA	0.353													T	105800946	T	T	105800946	3	4	179	1	0	0	0	0	1	0	0	0	12474	826	29	3	1444	3	PREP	6	105800946	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08		105800946	65314121	23	12729											
SLC29A4	222962	broad.mit.edu	37	chr7	5340251	5340251	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcggcagcgtgcccatgatcCtggcggcaggcaaagtgagc	15	12	0	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr7:5340251C>T	uc003sod.2	+	10	1569	c.1408C>T	c.(1408-1410)CTG>TTG	p.L470L	SLC29A4_uc003soc.2_Silent_p.L470L|SLC29A4_uc003soe.2_Silent_p.L456L|SLC29A4_uc010ksw.2_Intron	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	470	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		GCCCATGATCCTGGCGGCAGG	0.706													T	5340251	T	T	5340251	2	4	179	1	0	0	0	0	0	0	0	1	14537	680	24	3		3	SLC29A4	7	5340251	Silent	SNP	C	TCGA-26-5139-01A-01D-1486-08		5340251	153798412	24	12730											
DNAH11	8701	broad.mit.edu	37	chr7	21641054	21641054	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttataaaggagacagattccGgacttcagagagaattaaat	9	5	1	4			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr7:21641054G>A	uc003svc.2	+	18	3497	c.3466G>A	c.(3466-3468)GGA>AGA	p.G1156R		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1156	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GACAGATTCCGGACTTCAGAG	0.343									Kartagener_syndrome				A	21641054	A	A	21641054	3	1	179	1	0	0	0	0	1	0	0	0	4599	1117	39	2	3536	2	DNAH11	7	21641054	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	16300803	21641054	137497609	25	12731											
EGFR	1956	broad.mit.edu	37	chr7	55220278	55220278	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagcagtgctccgggcgctGccgtggcaagtcccccagtg	14	16	0	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr7:55220278G>A	uc003tqk.2	+	6	914	c.668G>A	c.(667-669)TGC>TAC	p.C223Y	EGFR_uc003tqh.2_Missense_Mutation_p.C223Y|EGFR_uc003tqi.2_Missense_Mutation_p.C223Y|EGFR_uc003tqj.2_Missense_Mutation_p.C223Y|EGFR_uc010kzg.1_Missense_Mutation_p.C178Y|EGFR_uc011kco.1_Missense_Mutation_p.C170Y|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	223	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCCGGGCGCTGCCGTGGCAAG	0.602		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55220278	A	A	55220278	3	1	179	1	0	0	0	0	1	0	0	0	4967	1319	46	3	690	3	EGFR	7	55220278	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	33579224	55220278	103918385	26	12732											
EGFR	1956	broad.mit.edu	37	chr7	55238870	55238870	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctctttcacttcctacagatGcactgggccaggtcttgaag	9	12	3	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr7:55238870G>T	uc003tqk.2	+	16	2129	c.1883G>T	c.(1882-1884)TGC>TTC	p.C628F	EGFR_uc010kzg.1_Missense_Mutation_p.C583F|EGFR_uc011kco.1_Missense_Mutation_p.C575F|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	628	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCCTACAGATGCACTGGGCCA	0.393		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55238870	T	T	55238870	3	4	179	1	0	0	0	0	1	0	0	0	4967	1319	46	5	2209	5	EGFR	7	55238870	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	18592	55238870	103899793	27	12733											
POM121C	100101267	broad.mit.edu	37	chr7	75068439	75068439	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tacttaggcacaaaagaagcGgggactccactggccaccag	11	12	0	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr7:75068439G>T	uc010lde.1	-	4	1017	c.1017C>A	c.(1015-1017)CCC>CCA	p.P339P	POM121C_uc003udk.3_Silent_p.P97P			A8CG34	P121C_HUMAN	Homo sapiens POM121-2 mRNA for nuclear pore membrane protein 121-2, partial cds.	339	Required for targeting to the nucleus and nuclear pore complex.|Pore side (Potential).|Ser-rich.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						CAAAAGAAGCGGGGACTCCAC	0.468													T	75068439	T	T	75068439	2	4	179	1	0	0	0	0	0	0	0	1	12240	1103	39	5		5	POM121C	7	75068439	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	19829569	75068439	84070224	28	12734											
MYOM2	9172	broad.mit.edu	37	chr8	2005570	2005570	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggcacgctcccaggcccGcgacaagctggacaaatacg	11	16	0	0	rs147661043		TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr8:2005570G>A	uc003wpx.3	+	4	506	c.368G>A	c.(367-369)CGC>CAC	p.R123H	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	123					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TCCCAGGCCCGCGACAAGCTG	0.617													A	2005570	A	A	2005570	3	1	179	1	0	0	0	0	1	0	0	0	10092	1087	38	1	378	1	MYOM2	8	2005570	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08		2005570	144358452	29	12735											
CHRNB3	1142	broad.mit.edu	37	chr8	42587374	42587374	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttcatcatgatttttgtgacCctgtccatcattgttaccgt	6	10	3	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr8:42587374C>A	uc003xpi.1	+	5	1052	c.924C>A	c.(922-924)ACC>ACA	p.T308T		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	308	Helical; (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TTTTTGTGACCCTGTCCATCA	0.448													A	42587374	A	A	42587374	2	1	179	1	0	0	0	0	0	0	0	1	3392	610	22	5		5	CHRNB3	8	42587374	Silent	SNP	C	TCGA-26-5139-01A-01D-1486-08	40581804	42587374	103776648	30	12736											
KCNV1	27012	broad.mit.edu	37	chr8	110984560	110984560	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctggacaatgcgccccacGttctccagctcctgcgtggt	10	16	1	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr8:110984560G>A	uc003ynr.3	-	2	1260	c.918C>T	c.(916-918)AAC>AAT	p.N306N	KCNV1_uc010mcw.2_Silent_p.N306N	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	306	Extracellular (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TGCGCCCCACGTTCTCCAGCT	0.532													A	110984560	A	A	110984560	2	1	179	1	0	0	0	0	0	0	0	1	8094	1136	40	1		1	KCNV1	8	110984560	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	68397186	110984560	35379462	31	12737											
GCNT1	2650	broad.mit.edu	37	chr9	79117571	79117571	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gccctcggtggacacctgacGactatataaacatgaccagt	9	12	0	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr9:79117571G>A	uc010mpf.2	+	3	615	c.274G>A	c.(274-276)GAC>AAC	p.D92N	GCNT1_uc010mpg.2_Missense_Mutation_p.D92N|GCNT1_uc010mph.2_Missense_Mutation_p.D92N|GCNT1_uc004akf.3_Missense_Mutation_p.D92N|GCNT1_uc010mpi.2_Missense_Mutation_p.D92N|GCNT1_uc004akh.3_Missense_Mutation_p.D92N	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	92	Lumenal (Potential).|Stem region (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						GACACCTGACGACTATATAAA	0.393													A	79117571	A	A	79117571	3	1	179	1	0	0	0	0	1	0	0	0	6300	1058	37	2	276	2	GCNT1	9	79117571	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08		79117571	62095860	32	12738											
OR4C46	119749	broad.mit.edu	37	chr11	51516009	51516009	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctgtgtctcccacatcaCggttgtcatcttattctttg	6	13	5	0	rs137991158		TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr11:51516009C>T	uc010ric.1	+	1	728	c.728C>T	c.(727-729)ACG>ATG	p.T243M		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCCCACATCACGGTTGTCATC	0.468													T	51516009	T	T	51516009	3	4	179	1	0	0	0	0	1	0	0	0	11051	536	19	1	730	1	OR4C46	11	51516009	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08		51516009	83490507	33	12739											
LRRC23	10233	broad.mit.edu	37	chr12	7021983	7021983	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcttgataacccatgcaCggacgaaaccagctaccgcc	9	15	0	1	rs78482853	by1000genomes	TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr12:7021983C>T	uc001qrt.3	+	7	1240	c.848C>T	c.(847-849)ACG>ATG	p.T283M	LRRC23_uc001qrp.2_Missense_Mutation_p.T283M|LRRC23_uc001qrq.2_Intron|LRRC23_uc001qrr.2_Missense_Mutation_p.T232M|LRRC23_uc001qrs.2_Intron|LRRC23_uc009zfh.2_Intron|ENO2_uc001qru.1_5'Flank|ENO2_uc009zfi.1_5'Flank|ENO2_uc010sfq.1_5'Flank|ENO2_uc001qrv.1_5'Flank	NM_001135217	NP_001128689	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23 isoform a	283	LRRCT.									ovary(1)	1						AACCCATGCACGGACGAAACC	0.602													T	7021983	T	T	7021983	3	4	179	1	0	0	0	0	1	0	0	0	8978	536	19	1	870	1	LRRC23	12	7021983	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08		7021983	126829912	34	12740											
PTPN6	5777	broad.mit.edu	37	chr12	7061224	7061224	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tatggaggggagaagtttgcGactctgacagagctggtgga	17	5	1	3			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr12:7061224G>A	uc001qsb.2	+	3	452	c.210G>A	c.(208-210)GCG>GCA	p.A70A	PTPN6_uc001qsa.1_Silent_p.A72A|PTPN6_uc010sfr.1_Silent_p.A31A|PTPN6_uc009zfl.1_Silent_p.A70A|PTPN6_uc010sfs.1_Silent_p.A58A	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	70	SH2 1.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						AGAAGTTTGCGACTCTGACAG	0.587													A	7061224	A	A	7061224	2	1	179	1	0	0	0	0	0	0	0	1	12792	1045	37	2		2	PTPN6	12	7061224	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	39241	7061224	126790671	35	12741											
ADAMTS20	80070	broad.mit.edu	37	chr12	43823483	43823483	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaacagttggtaataaagcGgtctcaagtttagaaataaa	9	4	1	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr12:43823483G>A	uc010skx.1	-	24	3426	c.3426C>T	c.(3424-3426)ACC>ACT	p.T1142T	ADAMTS20_uc001rno.1_Intron|ADAMTS20_uc001rnp.1_Silent_p.T296T	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1142						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTAATAAAGCGGTCTCAAGTT	0.338													A	43823483	A	A	43823483	2	1	179	1	0	0	0	0	0	0	0	1	266	1103	39	2		2	ADAMTS20	12	43823483	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	36762259	43823483	90028412	36	12742											
GALNT4	8693	broad.mit.edu	37	chr12	89917757	89917757	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cgtactctatcaagattgctGatgtaagtttcaagttgtgt	9	6	3	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr12:89917757G>T	uc001tbd.2	-	1	779	c.570C>A	c.(568-570)ATC>ATA	p.I190I	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Silent_p.I187I|GALNT4_uc010suo.1_Intron	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	190	Lumenal (Potential).|Catalytic subdomain A.				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						CAAGATTGCTGATGTAAGTTT	0.458											OREG0022018	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	89917757	T	T	89917757	2	4	179	1	0	0	0	0	0	0	0	1	6215	1280	45	5		5	GALNT4	12	89917757	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	46094274	89917757	43934138	37	12743											
RIC8B	55188	broad.mit.edu	37	chr12	107177813	107177814	+	Frame_Shift_Ins	INS	-	A	A													ttgaatcaacagatgaagatINSaaaagaaaggtaagccttgg							TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr12:107177813_107177814insA	uc001tlx.2	+	2	248_249	c.123_124insA	c.(121-126)GATAAAfs	p.D41fs	RIC8B_uc001tlw.2_Frame_Shift_Ins_p.D41fs|RIC8B_uc001tly.2_5'UTR|RIC8B_uc001tlz.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	41_42					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						CAGATGAAGATAAAAGAAAGGT	0.351													A	107177814	A	A	107177813	7	5	179	1	0	1	1	0	0	0	0	0	13356	1403	49	0	129	0	RIC8B	12	107177813	Frame_Shift_Ins	INS	-	TCGA-26-5139-01A-01D-1486-08	17260056	107177813	26674082	38	12744											
USP30	84749	broad.mit.edu	37	chr12	109495849	109495849	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagttcacctcccagtactcCagggatcagaaggagccccc	10	15	2	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr12:109495849C>A	uc010sxi.1	+	3	416	c.312C>A	c.(310-312)TCC>TCA	p.S104S	USP30_uc001tnu.3_Silent_p.S73S	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	104	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						CCCAGTACTCCAGGGATCAGA	0.478													A	109495849	A	A	109495849	2	1	179	1	0	0	0	0	0	0	0	1	17058	581	21	5		5	USP30	12	109495849	Silent	SNP	C	TCGA-26-5139-01A-01D-1486-08	2318036	109495849	24356046	39	12745											
CCDC60	160777	broad.mit.edu	37	chr12	119773039	119773039	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccccaactcgggggctgtcCggcccttttatgcctcggag	12	16	0	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr12:119773039C>T	uc001txe.2	+	1	523	c.58C>T	c.(58-60)CGG>TGG	p.R20W		NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	20										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GGGGGCTGTCCGGCCCTTTTA	0.463													T	119773039	T	T	119773039	3	4	179	1	0	0	0	0	1	0	0	0	2831	643	23	2	60	2	CCDC60	12	119773039	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08	10277190	119773039	14078856	40	12746											
EXD1	161829	broad.mit.edu	37	chr15	41501708	41501708	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatctttcacctgcagccaGcacagtttgccatggcgaca	8	13	2	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr15:41501708G>A	uc001znk.2	-	5	542	c.351C>T	c.(349-351)TGC>TGT	p.C117C	EXD1_uc010ucv.1_Silent_p.C175C	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	117	3'-5' exonuclease.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						CCTGCAGCCAGCACAGTTTGC	0.373													A	41501708	A	A	41501708	2	1	179	1	0	0	0	0	0	0	0	1	5297	963	34	3		3	EXD1	15	41501708	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08		41501708	61029684	41	12747											
PKD1L2	114780	broad.mit.edu	37	chr16	81175094	81175094	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgctgtccttccaggggccaCtccgtgccgccttgggcttg	13	16	0	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr16:81175094C>G	uc002fgh.1	-	31	5225	c.5225G>C	c.(5224-5226)AGT>ACT	p.S1742T	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1742	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCAGGGGCCACTCCGTGCCGC	0.582													G	81175094	G	G	81175094	3	3	179	1	0	0	0	0	1	0	0	0	11965	565	20	5	2205	5	PKD1L2	16	81175094	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08		81175094	9179659	42	12748											
POLR2A	5430	broad.mit.edu	37	chr17	7417217	7417217	+	Frame_Shift_Del	DEL	T	-	-													cccaagtactcgcctaccagTcccacctattcacccaccac							TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr17:7417217delT	uc002ghf.3	+	29	5868	c.5634delT	c.(5632-5634)AGTfs	p.S1878fs		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1878	41.|52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				CGCCTACCAGTcccacctatt	0.269													-	7417217	-	-	7417217	7	5	179	1	0	1	0	1	0	0	0	0	12214	1664	58	0	5748	0	POLR2A	17	7417217	Frame_Shift_Del	DEL	T	TCGA-26-5139-01A-01D-1486-08		7417217	73777993	43	12749											
AZI1	22994	broad.mit.edu	37	chr17	79164553	79164553	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccggtcctcgaactcctggCggatcacctgggccaggttg	14	14	1	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr17:79164553C>T	uc002jzp.1	-	24	3202	c.3002G>A	c.(3001-3003)CGC>CAC	p.R1001H	AZI1_uc002jzm.1_Missense_Mutation_p.R433H|AZI1_uc002jzn.1_Missense_Mutation_p.R998H|AZI1_uc002jzo.1_Missense_Mutation_p.R962H|AZI1_uc010wum.1_Missense_Mutation_p.R965H|AZI1_uc002jzq.2_Missense_Mutation_p.R149H	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	1001					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GAACTCCTGGCGGATCACCTG	0.692													T	79164553	T	T	79164553	3	4	179	1	0	0	0	0	1	0	0	0	1240	768	27	1	261	1	AZI1	17	79164553	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08	71747336	79164553	2030657	44	12750											
DSG4	147409	broad.mit.edu	37	chr18	28989414	28989414	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattgtcactttcttgggcaGtggctccactcttgctgctc	9	13	3	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr18:28989414G>A	uc002kwq.2	+	13	2069	c.1934_splice	c.e13-1	p.L645_splice	DSG4_uc002kwr.2_Splice_Site_p.L645_splice	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein						homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTCTTGGGCAGTGGCTCCACT	0.498													A	28989414	A	A	28989414	5	1	179	1	0	0	0	0	0	0	1	0	4779	1043	36	3	1983	3	DSG4	18	28989414	Splice_Site	SNP	G	TCGA-26-5139-01A-01D-1486-08		28989414	49087834	45	12751											
C18orf34	374864	broad.mit.edu	37	chr18	30950074	30950074	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	atgtgtgaaatcattttgttGacacaaggtgctggaatatt	10	4	1	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr18:30950074G>C	uc002kxn.2	-	5	430	c.288C>G	c.(286-288)GTC>GTG	p.V96V	C18orf34_uc010xbr.1_Silent_p.V96V|C18orf34_uc010dmf.1_Silent_p.V96V|C18orf34_uc002kxo.2_Silent_p.V96V|C18orf34_uc002kxp.2_Silent_p.V96V	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	96										ovary(1)	1						TCATTTTGTTGACACAAGGTG	0.378													C	30950074	C	C	30950074	2	2	179	1	0	0	0	0	0	0	0	1	1902	1277	45	5		5	C18orf34	18	30950074	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	1960660	30950074	47127174	46	12752											
SERPINB13	5275	broad.mit.edu	37	chr18	61262397	61262397	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtttgtgcttctgcccaaCgacatcgatggcctggagaa	11	10	1	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr18:61262397C>T	uc002ljc.2	+	7	918	c.750C>T	c.(748-750)AAC>AAT	p.N250N	SERPINB13_uc002ljd.2_Silent_p.N114N|SERPINB13_uc010xep.1_Silent_p.N259N|SERPINB13_uc010xeq.1_Silent_p.N71N|SERPINB13_uc010xer.1_Silent_p.N71N	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	250					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						TTCTGCCCAACGACATCGATG	0.458													T	61262397	T	T	61262397	2	4	179	1	0	0	0	0	0	0	0	1	14100	535	19	1		1	SERPINB13	18	61262397	Silent	SNP	C	TCGA-26-5139-01A-01D-1486-08	30312323	61262397	16814851	47	12753											
TJP3	27134	broad.mit.edu	37	chr19	3728405	3728405	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcctcatgcccatcttccCcgctcccctcgaccaggtgg	9	19	2	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr19:3728405C>T	uc010xhv.1	+	1	32	c.32C>T	c.(31-33)CCC>CTC	p.P11L	TJP3_uc010xhs.1_Intron|TJP3_uc010xht.1_Intron|TJP3_uc010xhu.1_Intron|TJP3_uc010xhw.1_Missense_Mutation_p.P11L	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	Error:Variant_position_missing_in_O95049_after_alignment						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCATCTTCCCCGCTCCCCTC	0.413													T	3728405	T	T	3728405	3	4	179	1	0	0	0	0	1	0	0	0	15928	623	22	3	34	3	TJP3	19	3728405	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08		3728405	55400578	48	12754											
CD70	970	broad.mit.edu	37	chr19	6586314	6586314	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaccatgtagatgccatcaCgatggatacgtagctgcccc	10	12	1	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr19:6586314C>T	uc002mfi.2	-	3	449	c.299G>A	c.(298-300)CGT>CAT	p.R100H	CD70_uc010xjf.1_Missense_Mutation_p.R100H	NM_001252	NP_001243	P32970	CD70_HUMAN	tumor necrosis factor ligand superfamily, member	100	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to membrane of membrane fraction|integral to plasma membrane	cytokine activity|protease binding|tumor necrosis factor receptor binding				0						GATGCCATCACGATGGATACG	0.642													T	6586314	T	T	6586314	3	4	179	1	0	0	0	0	1	0	0	0	3033	536	19	1	286	1	CD70	19	6586314	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08	2857909	6586314	52542669	49	12755											
RETN	56729	broad.mit.edu	37	chr19	7734784	7734784	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctggctacttgcccccgaGgtgagtgcaggagactgttg	14	11	0	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr19:7734784G>A	uc002mhf.1	+	3	242	c.196G>A	c.(196-198)GGC>AGC	p.G66S	RETN_uc002mhg.1_Missense_Mutation_p.G66S|RETN_uc010dvm.1_Intron	NM_020415	NP_065148	Q9HD89	RETN_HUMAN	resistin	66							hormone activity			ovary(1)	1						TTGCCCCCGAGGTGAGTGCAG	0.627													A	7734784	A	A	7734784	3	1	179	1	0	0	0	0	1	0	0	0	13236	1014	35	3	202	3	RETN	19	7734784	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	1148470	7734784	51394199	50	12756											
PODNL1	79883	broad.mit.edu	37	chr19	14046601	14046601	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggttggcagccagatccgCgacacggagggaccggggca	17	11	0	1	rs147712582	byFrequency	TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr19:14046601C>T	uc002mxr.2	-	5	722	c.448G>A	c.(448-450)GCG>ACG	p.A150T	PODNL1_uc010xni.1_Missense_Mutation_p.A68T|PODNL1_uc010xnj.1_Missense_Mutation_p.A148T|PODNL1_uc002mxs.2_Intron	NM_024825	NP_079101	Q6PEZ8	PONL1_HUMAN	podocan-like 1 isoform 1	150	Leu-rich.|LRR 4.					proteinaceous extracellular matrix				central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(19;5.26e-23)			GCCAGATCCGCGACACGGAGG	0.667													T	14046601	T	T	14046601	3	4	179	1	0	0	0	0	1	0	0	0	12179	768	27	1	1106	1	PODNL1	19	14046601	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08	6311817	14046601	45082382	51	12757											
FCGBP	8857	broad.mit.edu	37	chr19	40395990	40395990	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acgcaggtgcccatgaagtcGaagcggcggccatcgaaggt	15	11	0	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr19:40395990G>A	uc002omp.3	-	15	7415	c.7407C>T	c.(7405-7407)TTC>TTT	p.F2469F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2469	VWFD 6.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCATGAAGTCGAAGCGGCGGC	0.672													A	40395990	A	A	40395990	2	1	179	1	0	0	0	0	0	0	0	1	5778	1049	37	2		2	FCGBP	19	40395990	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	26349389	40395990	18732993	52	12758											
PRR12	57479	broad.mit.edu	37	chr19	50105110	50105110	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaggccggcgagagtggcGgagagggcatcttccgggaa	20	8	1	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr19:50105110G>A	uc002poo.3	+	6	4708	c.4708G>A	c.(4708-4710)GGA>AGA	p.G1570R		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	749							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CGAGAGTGGCGGAGAGGGCAT	0.647													A	50105110	A	A	50105110	3	1	179	1	0	0	0	0	1	0	0	0	12584	1117	39	2	4730	2	PRR12	19	50105110	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	9709120	50105110	9023873	53	12759											
TMPRSS6	164656	broad.mit.edu	37	chr22	37482392	37482392	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcaggcccttcttccagaCgaccgccatgatggcccccg	11	17	1	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chr22:37482392C>T	uc003aqs.1	-	8	1045	c.931G>A	c.(931-933)GTC>ATC	p.V311I	TMPRSS6_uc003aqt.1_Missense_Mutation_p.V302I|TMPRSS6_uc003aqu.2_Missense_Mutation_p.V302I	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	311	CUB 1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						TTCTTCCAGACGACCGCCATG	0.667													T	37482392	T	T	37482392	3	4	179	1	0	0	0	0	1	0	0	0	16248	536	19	1	1548	1	TMPRSS6	22	37482392	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08		37482392	13822174	54	12760											
FAM47B	170062	broad.mit.edu	37	chrX	34962542	34962542	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taaaatactgggacaggagaCgccgggcggcaccgcattct	13	11	1	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chrX:34962542C>T	uc004ddi.1	+	1	1612	c.1594C>T	c.(1594-1596)CGC>TGC	p.R532C		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	532										ovary(3)|breast(1)	4						GGACAGGAGACGCCGGGCGGC	0.498													T	34962542	T	T	34962542	3	4	179	1	0	0	0	0	1	0	0	0	5570	536	19	1	1596	1	FAM47B	23	34962542	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08		34962542	120308018	55	12761											
WNK3	65267	broad.mit.edu	37	chrX	54319681	54319681	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgagagcccatcgtttgattTgaggaataggctacactggg	13	7	0	3			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chrX:54319681T>C	uc004dtd.1	-	9	2212	c.1773A>G	c.(1771-1773)TCA>TCG	p.S591S	WNK3_uc004dtc.1_Silent_p.S591S	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	591					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TCGTTTGATTTGAGGAATAGG	0.398													C	54319681	C	C	54319681	2	2	179	1	0	0	0	0	0	0	0	1	17376	1799	63	4		4	WNK3	23	54319681	Silent	SNP	T	TCGA-26-5139-01A-01D-1486-08	19357139	54319681	100950879	56	12762											
LAS1L	81887	broad.mit.edu	37	chrX	64744052	64744052	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctctccaatagggcctgcGtgaagttctgggagtgcagg	14	10	2	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chrX:64744052G>A	uc004dwa.1	-	10	1256	c.1184C>T	c.(1183-1185)ACG>ATG	p.T395M	LAS1L_uc004dwc.1_Missense_Mutation_p.T378M|LAS1L_uc004dwd.1_Missense_Mutation_p.T336M	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	395						MLL1 complex|nucleolus	protein binding	p.T395T(1)		ovary(3)|large_intestine(1)	4						TAGGGCCTGCGTGAAGTTCTG	0.567													A	64744052	A	A	64744052	3	1	179	1	0	0	0	0	1	0	0	0	8636	1145	40	1	1040	1	LAS1L	23	64744052	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	10424371	64744052	90526508	57	12763											
BTK	695	broad.mit.edu	37	chrX	100611220	100611220	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcgctgcttggtgcagacGccatacaactgcaccagctt	12	13	0	1			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chrX:100611220G>A	uc004ehg.2	-	15	1579	c.1386C>T	c.(1384-1386)GGC>GGT	p.G462G	BTK_uc004ehf.2_Intron|BTK_uc010nnh.2_Intron|BTK_uc010nni.2_Intron|BTK_uc004ehe.2_Intron|BTK_uc010nnj.2_RNA|BTK_uc010nnk.2_Intron|BTK_uc010nnl.2_Intron|BTK_uc010nnm.2_Silent_p.G32G|BTK_uc010nnn.2_Intron|BTK_uc010nno.2_Silent_p.G496G|BTK_uc004ehh.1_Intron|BTK_uc004ehi.2_Silent_p.G462G	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	462	Protein kinase.		G -> D (in XLA).|G -> V (in XLA).		calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TGGTGCAGACGCCATACAACT	0.522									Agammaglobulinemia_X-linked				A	100611220	A	A	100611220	2	1	179	1	0	0	0	0	0	0	0	1	1557	1074	38	1		1	BTK	23	100611220	Silent	SNP	G	TCGA-26-5139-01A-01D-1486-08	35867168	100611220	54659340	58	12764											
SOX3	6658	broad.mit.edu	37	chrX	139586734	139586734	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttgctgatctcagaattgtgCatcttggggttctccagggc	12	9	3	2			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chrX:139586734C>G	uc004fbd.1	-	1	492	c.492G>C	c.(490-492)ATG>ATC	p.M164I		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	164	HMG box.				face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					CAGAATTGTGCATCTTGGGGT	0.622													G	139586734	G	G	139586734	3	3	179	1	0	0	0	0	1	0	0	0	14951	710	25	5	852	5	SOX3	23	139586734	Missense_Mutation	SNP	C	TCGA-26-5139-01A-01D-1486-08	38975514	139586734	15683826	59	12765											
PNMA5	114824	broad.mit.edu	37	chrX	152159506	152159506	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attgttggcctggagcacccGcatgattgacagagcaggcc	13	11	0	3			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chrX:152159506G>A	uc010ntw.2	-	3	976	c.637C>T	c.(637-639)CGG>TGG	p.R213W	PNMA5_uc004fha.3_Missense_Mutation_p.R213W|PNMA5_uc010ntx.2_Missense_Mutation_p.R213W|PNMA5_uc004fgy.3_Missense_Mutation_p.R213W	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	213					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TGGAGCACCCGCATGATTGAC	0.527													A	152159506	A	A	152159506	3	1	179	1	0	0	0	0	1	0	0	0	12156	1086	38	1	713	1	PNMA5	23	152159506	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	12572772	152159506	3111054	60	12766											
F8	2157	broad.mit.edu	37	chrX	154185438	154185438	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aattggaaaatccttcaaatGttttacacctacccacaagc	4	11	1	0			TCGA-26-5139-01A-01D-1486-08	TCGA-26-5139-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	8199001b-a3c9-47e1-97cf-943fa8030f46	0be951d5-b639-4125-996c-c1245d7750ee	g.chrX:154185438G>A	uc004fmt.2	-	11	1717	c.1546C>T	c.(1546-1548)CAT>TAT	p.H516Y		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	516	F5/8 type A 2.|Plastocyanin-like 3.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCCTTCAAATGTTTTACACCT	0.378													A	154185438	A	A	154185438	3	1	179	1	0	0	0	0	1	0	0	0	5350	1377	48	3	5601	3	F8	23	154185438	Missense_Mutation	SNP	G	TCGA-26-5139-01A-01D-1486-08	2025932	154185438	1085122	61	12767											
UBR4	23352	broad.mit.edu	37	chr1	19504071	19504071	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgagcatccatgttgacgcTcaactcctggatgatctgga	10	11	2	3			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr1:19504071T>C	uc001bbi.2	-	19	2525	c.2521A>G	c.(2521-2523)AGC>GGC	p.S841G	UBR4_uc001bbm.1_Missense_Mutation_p.S52G	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	841					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ATGTTGACGCTCAACTCCTGG	0.507													C	19504071	C	C	19504071	3	2	180	1	0	0	0	0	1	0	0	0	16901	1551	54	4	13382	4	UBR4	1	19504071	Missense_Mutation	SNP	T	TCGA-26-6173-01A-11D-1845-08		19504071	229746550	1	12768											
ZNF643	65243	broad.mit.edu	37	chr1	40919923	40919923	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccagggcgaaagtttagagaGtagagtgacccttggatccc	13	9	0	3			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr1:40919923G>T	uc001cfn.1	+	2	473	c.176G>T	c.(175-177)AGT>ATT	p.S59I	ZNF643_uc001cfl.1_Intron|ZNF643_uc001cfm.1_5'UTR	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	59					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			AGTTTAGAGAGTAGAGTGACC	0.493													T	40919923	T	T	40919923	3	4	180	1	0	0	0	0	1	0	0	0	18056	1029	36	5	182	5	ZNF643	1	40919923	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08	21415852	40919923	208330698	2	12769											
HRNR	388697	broad.mit.edu	37	chr1	152192865	152192865	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatccagagctgtgttggcCgcggcctgaagagtgacggg	17	9	0	5			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr1:152192865C>T	uc001ezt.1	-	3	1316	c.1240G>A	c.(1240-1242)GGC>AGC	p.G414S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	414	4.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTGTTGGCCGCGGCCTGAA	0.632													T	152192865	T	T	152192865	3	4	180	1	0	0	0	0	1	0	0	0	7359	652	23	2	7316	2	HRNR	1	152192865	Missense_Mutation	SNP	C	TCGA-26-6173-01A-11D-1845-08	111272942	152192865	97057756	3	12770											
FLG	2312	broad.mit.edu	37	chr1	152283171	152283171	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcttctgaatgtccctcactGttagtgacctgactaccact	6	13	3	3			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr1:152283171G>C	uc001ezu.1	-	3	4227	c.4191C>G	c.(4189-4191)AAC>AAG	p.N1397K	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1397	Ser-rich.|Filaggrin 8.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCCTCACTGTTAGTGACCT	0.567									Ichthyosis				C	152283171	C	C	152283171	3	2	180	1	0	0	0	0	1	0	0	0	5922	1368	48	5	7998	5	FLG	1	152283171	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08	90306	152283171	96967450	4	12771											
LCE1C	353133	broad.mit.edu	37	chr1	152777634	152777634	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtgctggccactccccccGccacagcagctggagccccc	11	20	0	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr1:152777634G>A	uc001fap.1	-	2	372	c.321C>T	c.(319-321)GGC>GGT	p.G107G		NM_178351	NP_848128	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	107	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACTCCCCCCGCCACAGCAGC	0.662													A	152777634	A	A	152777634	2	1	180	1	0	0	0	0	0	0	0	1	8661	1074	38	1		1	LCE1C	1	152777634	Silent	SNP	G	TCGA-26-6173-01A-11D-1845-08	494463	152777634	96472987	5	12772											
OR10R2	343406	broad.mit.edu	37	chr1	158449884	158449884	+	Frame_Shift_Del	DEL	A	-	-													tcagtgtcatccacctggatAaaagcctccacacaccaatg							TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr1:158449884delA	uc010pik.1	+	1	217	c.217delA	c.(217-219)AAAfs	p.K73fs	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	73	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					CCACCTGGATAAAAGCCTCCA	0.418													-	158449884	-	-	158449884	7	5	180	1	0	1	0	1	0	0	0	0	10917	363	13	0	219	0	OR10R2	1	158449884	Frame_Shift_Del	DEL	A	TCGA-26-6173-01A-11D-1845-08	5672250	158449884	90800737	6	12773											
ARHGAP15	55843	broad.mit.edu	37	chr2	144381721	144381721	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagagaagctgaatttggaCgacagccagtgggaggacat	15	6	0	2	rs138120208		TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr2:144381721C>T	uc002tvm.3	+	12	1174	c.1023C>T	c.(1021-1023)GAC>GAT	p.D341D	ARHGAP15_uc002tvn.2_Silent_p.D107D	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	341	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TGAATTTGGACGACAGCCAGT	0.448													T	144381721	T	T	144381721	2	4	180	1	0	0	0	0	0	0	0	1	866	535	19	1		1	ARHGAP15	2	144381721	Silent	SNP	C	TCGA-26-6173-01A-11D-1845-08		144381721	98817652	7	12774											
ZDBF2	57683	broad.mit.edu	37	chr2	207174442	207174442	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gctgataaaaaaaaacgttcGaagctaaaacatagagatct	7	6	1	2	rs140337696	by1000genomes	TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr2:207174442G>A	uc002vbp.2	+	5	5440	c.5190G>A	c.(5188-5190)TCG>TCA	p.S1730S		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1730							nucleic acid binding|zinc ion binding			ovary(3)	3						AAAAACGTTCGAAGCTAAAAC	0.458													A	207174442	A	A	207174442	2	1	180	1	0	0	0	0	0	0	0	1	17596	1045	37	2		2	ZDBF2	2	207174442	Silent	SNP	G	TCGA-26-6173-01A-11D-1845-08	62792721	207174442	36024931	8	12775											
ITGA9	3680	broad.mit.edu	37	chr3	37555330	37555330	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctctgacctgctggtgggggCccccatgttttctgagatca	12	12	3	2			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr3:37555330C>A	uc003chd.2	+	9	1027	c.974C>A	c.(973-975)GCC>GAC	p.A325D	ITGA9_uc003chc.2_Missense_Mutation_p.A325D	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	325	Extracellular (Potential).|FG-GAP 5.				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		CTGGTGGGGGCCCCCATGTTT	0.547													A	37555330	A	A	37555330	3	1	180	1	0	0	0	0	1	0	0	0	7883	739	26	5	1008	5	ITGA9	3	37555330	Missense_Mutation	SNP	C	TCGA-26-6173-01A-11D-1845-08		37555330	160467100	9	12776											
NBEAL2	23218	broad.mit.edu	37	chr3	47040321	47040321	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcagcagatgacgtgcaggtCacgcagaccatgctgagctt	12	11	2	4			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr3:47040321C>T	uc003cqp.2	+	23	3515	c.3336C>T	c.(3334-3336)GTC>GTT	p.V1112V	NBEAL2_uc010hjm.1_Silent_p.V673V	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1112							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		ACGTGCAGGTCACGCAGACCA	0.672											OREG0015546	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	47040321	T	T	47040321	2	4	180	1	0	0	0	0	0	0	0	1	10189	813	29	3		3	NBEAL2	3	47040321	Silent	SNP	C	TCGA-26-6173-01A-11D-1845-08	9484991	47040321	150982109	10	12777											
NLGN1	22871	broad.mit.edu	37	chr3	173525621	173525621	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aactatcgacttggagtactCggtaagaagagtctctcttt	9	8	2	2			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr3:173525621C>T	uc003fio.1	+	4	1068	c.645C>T	c.(643-645)CTC>CTT	p.L215L	NLGN1_uc010hww.1_Silent_p.L255L|NLGN1_uc003fip.1_Silent_p.L215L	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	232	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TTGGAGTACTCGGTAAGAAGA	0.323													T	173525621	T	T	173525621	2	4	180	1	0	0	0	0	0	0	0	1	10461	898	31	2		2	NLGN1	3	173525621	Silent	SNP	C	TCGA-26-6173-01A-11D-1845-08	126485300	173525621	24496809	11	12778											
CLNK	116449	broad.mit.edu	37	chr4	10522452	10522452	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggttgcttgtcgtgaatgaAgaactataagaaaatatgtt	10	3	0	4			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr4:10522452A>G	uc003gmo.3	-	15	872	c.735T>C	c.(733-735)TCT>TCC	p.S245S		NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	245	Poly-Ser.				immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						TCGTGAATGAAGAACTATAAG	0.363													G	10522452	G	G	10522452	2	3	180	1	0	0	0	0	0	0	0	1	3547	59	3	4		4	CLNK	4	10522452	Silent	SNP	A	TCGA-26-6173-01A-11D-1845-08		10522452	180631824	12	12779											
SLC30A9	10463	broad.mit.edu	37	chr4	42080309	42080309	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatattattgatactttaggAgctgaagtagatagacttga	9	3	0	5			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr4:42080309A>G	uc003gwl.2	+	17	1775	c.1629A>G	c.(1627-1629)GGA>GGG	p.G543G	SLC30A9_uc011byx.1_Silent_p.G303G	NM_006345	NP_006336	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter),	543					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3						ATACTTTAGGAGCTGAAGTAG	0.239													G	42080309	G	G	42080309	2	3	180	1	0	0	0	0	0	0	0	1	14562	291	11	4		4	SLC30A9	4	42080309	Silent	SNP	A	TCGA-26-6173-01A-11D-1845-08	31557857	42080309	149073967	13	12780											
SMR3B	10879	broad.mit.edu	37	chr4	71255517	71255517	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaatcccacctcctcctccCgcaccctatggtccagggat	7	18	0	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr4:71255517C>T	uc011cas.1	+	3	273	c.192C>T	c.(190-192)CCC>CCT	p.P64P	SMR3B_uc003hfh.2_Silent_p.P64P	NM_006685	NP_006676	P02814	SMR3B_HUMAN	submaxillary gland androgen regulated protein 3	64	Poly-Pro.|Pro-rich.					extracellular space				skin(1)	1		all_hematologic(202;0.196)				CTCCTCCTCCCGCACCCTATG	0.602													T	71255517	T	T	71255517	2	4	180	1	0	0	0	0	0	0	0	1	14812	639	23	2		2	SMR3B	4	71255517	Silent	SNP	C	TCGA-26-6173-01A-11D-1845-08	29175208	71255517	119898759	14	12781											
IRX1	79192	broad.mit.edu	37	chr5	3599499	3599499	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagcacgctcaaggcctggcTcaacgagcaccgcaagaatc	10	15	2	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr5:3599499T>G	uc003jde.2	+	2	489	c.437T>G	c.(436-438)CTC>CGC	p.L146R		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	146	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						AAGGCCTGGCTCAACGAGCAC	0.637													G	3599499	G	G	3599499	3	3	180	1	0	0	0	0	1	0	0	0	7843	1551	54	5	443	5	IRX1	5	3599499	Missense_Mutation	SNP	T	TCGA-26-6173-01A-11D-1845-08		3599499	177315761	15	12782											
MAP3K1	4214	broad.mit.edu	37	chr5	56176540	56176540	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttcctttgtttttagccGcacaagtcagctgtccatat	6	11	1	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr5:56176540G>A	uc003jqw.3	+	12	2591	c.2090G>A	c.(2089-2091)CGC>CAC	p.R697H		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	697					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GTTTTTAGCCGCACAAGTCAG	0.398													A	56176540	A	A	56176540	3	1	180	1	0	0	0	0	1	0	0	0	9243	1087	38	1	2136	1	MAP3K1	5	56176540	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08	52577041	56176540	124738720	16	12783											
CMYA5	202333	broad.mit.edu	37	chr5	79029879	79029879	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tccagccgactttaaaaaggGaggaaatcaagaaataggcc	10	8	1	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr5:79029879G>T	uc003kgc.2	+	2	5363	c.5291G>T	c.(5290-5292)GGA>GTA	p.G1764V		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1764						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTTAAAAAGGGAGGAAATCAA	0.413													T	79029879	T	T	79029879	3	4	180	1	0	0	0	0	1	0	0	0	3590	1174	41	5	5297	5	CMYA5	5	79029879	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08	22853339	79029879	101885381	17	12784											
FAM81B	153643	broad.mit.edu	37	chr5	94749823	94749823	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcgaaaagaggaatcgctcGccaggaagttactggaaagc	12	8	0	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr5:94749823G>A	uc003kla.1	+	4	512	c.466G>A	c.(466-468)GCC>ACC	p.A156T	FAM81B_uc010jbe.1_5'UTR	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	156										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		GGAATCGCTCGCCAGGAAGTT	0.458													A	94749823	A	A	94749823	3	1	180	1	0	0	0	0	1	0	0	0	5629	1087	38	1	480	1	FAM81B	5	94749823	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08	15719944	94749823	86165437	18	12785											
GABRA6	2559	broad.mit.edu	37	chr5	161128647	161128647	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cccccaccactctcgccagcCtttggaggcaccagtaaaat	7	17	1	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr5:161128647C>A	uc003lyu.2	+	9	1568	c.1230C>A	c.(1228-1230)GCC>GCA	p.A410A	GABRA6_uc003lyv.2_Silent_p.A181A	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	410	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCTCGCCAGCCTTTGGAGGCA	0.468										TCGA Ovarian(5;0.080)			A	161128647	A	A	161128647	2	1	180	1	0	0	0	0	0	0	0	1	6165	668	24	5		5	GABRA6	5	161128647	Silent	SNP	C	TCGA-26-6173-01A-11D-1845-08	66378824	161128647	19786613	19	12786											
CAP2	10486	broad.mit.edu	37	chr6	17543298	17543298	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttctccccacagacaactGtaaaaaactcggcctggtgt	7	12	1	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr6:17543298G>A	uc003ncb.2	+	11	1376	c.1133G>A	c.(1132-1134)TGT>TAT	p.C378Y	CAP2_uc010jpk.1_RNA|CAP2_uc011dja.1_Missense_Mutation_p.C352Y|CAP2_uc011djb.1_Missense_Mutation_p.C314Y|CAP2_uc011djc.1_Missense_Mutation_p.C266Y|CAP2_uc011djd.1_Missense_Mutation_p.C118Y	NM_006366	NP_006357	P40123	CAP2_HUMAN	adenylyl cyclase-associated protein 2	378	C-CAP/cofactor C-like.				activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			ACAGACAACTGTAAAAAACTC	0.403													A	17543298	A	A	17543298	3	1	180	1	0	0	0	0	1	0	0	0	2620	1377	48	3	1171	3	CAP2	6	17543298	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08		17543298	153571769	20	12787											
ROS1	6098	broad.mit.edu	37	chr6	117638305	117638305	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttatggatcccaactgcctaCcgttgccatccgggctttac	8	14	0	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr6:117638305C>T	uc003pxp.1	-	38	6334	c.6135_splice	c.e38+1	p.T2045_splice	ROS1_uc011ebi.1_Splice_Site	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor						transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CAACTGCCTACCGTTGCCATC	0.403			T	GOPC|ROS1	glioblastoma|NSCLC								T	117638305	T	T	117638305	5	4	180	1	0	0	0	0	0	0	1	0	13531	521	18	3	931	3	ROS1	6	117638305	Splice_Site	SNP	C	TCGA-26-6173-01A-11D-1845-08	100095007	117638305	53476762	21	12788											
DAGLB	221955	broad.mit.edu	37	chr7	6449599	6449599	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcatcttcggacctatgaGtattttgctgaattccgctt	9	9	1	2			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr7:6449599G>A	uc003sqa.2	-	15	2058	c.1888C>T	c.(1888-1890)CTC>TTC	p.L630F	DAGLB_uc003spy.2_Missense_Mutation_p.L176F|DAGLB_uc003spz.2_Missense_Mutation_p.L327F|DAGLB_uc011jwt.1_Missense_Mutation_p.L444F|DAGLB_uc011jwu.1_Missense_Mutation_p.L501F|DAGLB_uc003sqb.2_Missense_Mutation_p.L349F|DAGLB_uc003sqc.2_Missense_Mutation_p.L349F|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Missense_Mutation_p.L589F	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	630	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		GGACCTATGAGTATTTTGCTG	0.577													A	6449599	A	A	6449599	3	1	180	1	0	0	0	0	1	0	0	0	4227	1029	36	3	134	3	DAGLB	7	6449599	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08		6449599	152689064	22	12789											
FBXO24	26261	broad.mit.edu	37	chr7	100198322	100198322	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caccccaggaccccggggggAtggcccaggcctgcgaggag	17	15	0	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr7:100198322A>G	uc003uvm.1	+	10	1836	c.1543A>G	c.(1543-1545)ATG>GTG	p.M515V	FBXO24_uc003uvn.1_Missense_Mutation_p.M153V|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.M553V|FBXO24_uc011kka.1_Missense_Mutation_p.M503V|PCOLCE_uc011kkb.1_5'Flank|PCOLCE_uc003uvo.2_5'Flank|PCOLCE_uc010lhb.1_5'Flank	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	515						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCCCGGGGGGATGGCCCAGGC	0.662													G	100198322	G	G	100198322	3	3	180	1	0	0	0	0	1	0	0	0	5735	333	12	4	1738	4	FBXO24	7	100198322	Missense_Mutation	SNP	A	TCGA-26-6173-01A-11D-1845-08	93748723	100198322	58940341	23	12790											
NOM1	64434	broad.mit.edu	37	chr7	156743012	156743012	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaagctggagcgttgcctcgGtttgaacaagcgcaaaaaga	12	8	0	2			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr7:156743012G>A	uc003wmy.2	+	1	596	c.581G>A	c.(580-582)GGT>GAT	p.G194D		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	194	Necessary for nucleolar localization and for targeting PPP1CA to the nucleolus.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		CGTTGCCTCGGTTTGAACAAG	0.617													A	156743012	A	A	156743012	3	1	180	1	0	0	0	0	1	0	0	0	10530	1261	44	3	583	3	NOM1	7	156743012	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08	56544690	156743012	2395651	24	12791											
CYP11B1	1584	broad.mit.edu	37	chr8	143960555	143960555	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgttgcagcttctccacGtcctccggcagcatcacaca	7	17	2	0	rs5284		TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr8:143960555G>A	uc003yxi.2	-	2	295	c.288C>T	c.(286-288)GAC>GAT	p.D96D	CYP11B1_uc003yxh.2_5'Flank|CYP11B1_uc003yxj.2_Silent_p.D96D|CYP11B1_uc010mey.2_Silent_p.D141D	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	96					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GCTTCTCCACGTCCTCCGGCA	0.627									Familial_Hyperaldosteronism_type_I				A	143960555	A	A	143960555	2	1	180	1	0	0	0	0	0	0	0	1	4145	1136	40	1		1	CYP11B1	8	143960555	Silent	SNP	G	TCGA-26-6173-01A-11D-1845-08		143960555	2403467	25	12792											
CACNA1B	774	broad.mit.edu	37	chr9	140809200	140809200	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gccatcctcatgtttgccatCattggcctggagttctacat	8	12	3	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr9:140809200C>T	uc004cog.2	+	5	862	c.717C>T	c.(715-717)ATC>ATT	p.I239I		NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	239	Helical; Name=S5 of repeat I; (Potential).|I.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGTTTGCCATCATTGGCCTGG	0.567													T	140809200	T	T	140809200	2	4	180	1	0	0	0	0	0	0	0	1	2539	816	29	3		3	CACNA1B	9	140809200	Silent	SNP	C	TCGA-26-6173-01A-11D-1845-08		140809200	404231	26	12793											
DMBT1	1755	broad.mit.edu	37	chr10	124376759	124376759	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tacagacacttggccaacctCtcgtgcatcaacagcaggta	8	13	2	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr10:124376759C>G	uc001lgk.1	+	37	4593	c.4487C>G	c.(4486-4488)TCT>TGT	p.S1496C	DMBT1_uc001lgl.1_Missense_Mutation_p.S1486C|DMBT1_uc001lgm.1_Missense_Mutation_p.S868C|DMBT1_uc009xzz.1_Missense_Mutation_p.S1496C|DMBT1_uc010qtx.1_Missense_Mutation_p.S347C|DMBT1_uc009yab.1_Missense_Mutation_p.S199C	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1496					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGGCCAACCTCTCGTGCATCA	0.448													G	124376759	G	G	124376759	3	3	180	1	0	0	0	0	1	0	0	0	4577	913	32	5	4633	5	DMBT1	10	124376759	Missense_Mutation	SNP	C	TCGA-26-6173-01A-11D-1845-08		124376759	11157988	27	12794											
CKAP5	9793	broad.mit.edu	37	chr11	46783673	46783673	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acagctatttcctttaaggcTtttcctggggttggttggca	11	8	0	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr11:46783673T>C	uc001ndi.1	-	32	4208	c.4098A>G	c.(4096-4098)AAA>AAG	p.K1366K	CKAP5_uc009ylg.1_Silent_p.K1252K|CKAP5_uc001ndj.1_Silent_p.K1366K|CKAP5_uc001ndh.1_Silent_p.K295K	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1366	HEAT 10.				cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CCTTTAAGGCTTTTCCTGGGG	0.478													C	46783673	C	C	46783673	2	2	180	1	0	0	0	0	0	0	0	1	3445	1606	56	4		4	CKAP5	11	46783673	Silent	SNP	T	TCGA-26-6173-01A-11D-1845-08		46783673	88222843	28	12795											
OR8K3	219473	broad.mit.edu	37	chr11	56085805	56085805	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaacaacacaatctaacaaCggtgaatgaattcattctta	6	8	3	2			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr11:56085805C>T	uc010rjf.1	+	1	23	c.23C>T	c.(22-24)ACG>ATG	p.T8M		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					AATCTAACAACGGTGAATGAA	0.413													T	56085805	T	T	56085805	3	4	180	1	0	0	0	0	1	0	0	0	11244	536	19	1	25	1	OR8K3	11	56085805	Missense_Mutation	SNP	C	TCGA-26-6173-01A-11D-1845-08	9302132	56085805	78920711	29	12796											
MS4A3	932	broad.mit.edu	37	chr11	59828705	59828705	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtaccccaggcagtgaggcGggaccagaagagctgaatac	15	10	0	4			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr11:59828705G>A	uc001nom.2	+	2	200	c.72G>A	c.(70-72)GCG>GCA	p.A24A	MS4A3_uc001non.2_Silent_p.A24A|MS4A3_uc001noo.2_Intron	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	24	Cytoplasmic (Potential).			A -> T (in Ref. 1; AAA62319).		endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				GCAGTGAGGCGGGACCAGAAG	0.493													A	59828705	A	A	59828705	2	1	180	1	0	0	0	0	0	0	0	1	9861	1103	39	2		2	MS4A3	11	59828705	Silent	SNP	G	TCGA-26-6173-01A-11D-1845-08	3742900	59828705	75177811	30	12797											
SIPA1	6494	broad.mit.edu	37	chr11	65417064	65417064	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaggccccagtcctgcccaAcaccaccccggacctcctcc	7	22	0	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr11:65417064A>C	uc001ofb.2	+	11	2725	c.2558A>C	c.(2557-2559)AAC>ACC	p.N853T	SIPA1_uc010rom.1_Missense_Mutation_p.N751T|SIPA1_uc001ofd.2_Missense_Mutation_p.N853T	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	853					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						GTCCTGCCCAACACCACCCCG	0.642													C	65417064	C	C	65417064	3	2	180	1	0	0	0	0	1	0	0	0	14328	43	2	5	2596	5	SIPA1	11	65417064	Missense_Mutation	SNP	A	TCGA-26-6173-01A-11D-1845-08	5588359	65417064	69589452	31	12798											
MMP3	4314	broad.mit.edu	37	chr11	102709964	102709964	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcttcctgagggatttgcGccaaaagtgcctaaaatata	9	8	0	1	rs147533686	by1000genomes	TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr11:102709964G>A	uc001phj.1	-	7	1011	c.946C>T	c.(946-948)CGC>TGC	p.R316C		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	316	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.R316C(1)		lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	AGGGATTTGCGCCAAAAGTGC	0.403													A	102709964	A	A	102709964	3	1	180	1	0	0	0	0	1	0	0	0	9666	1087	38	1	503	1	MMP3	11	102709964	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08	37292900	102709964	32296552	32	12799											
MANSC1	54682	broad.mit.edu	37	chr12	12483054	12483054	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggattctacccaggaggacGaggcctatcaccaggaacag	12	11	2	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr12:12483054G>A	uc001rai.1	-	4	1461	c.1203C>T	c.(1201-1203)CTC>CTT	p.L401L	MANSC1_uc010shm.1_Silent_p.L335L|MANSC1_uc001raj.1_Silent_p.L367L|MANSC1_uc009zht.1_Silent_p.L320L	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	401	Helical; (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		CCAGGAGGACGAGGCCTATCA	0.488													A	12483054	A	A	12483054	2	1	180	1	0	0	0	0	0	0	0	1	9224	1045	37	2		2	MANSC1	12	12483054	Silent	SNP	G	TCGA-26-6173-01A-11D-1845-08		12483054	121368841	33	12800											
C14orf39	317761	broad.mit.edu	37	chr14	60945101	60945101	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgaaaaacatcacatgttggCttccagctatagaaaaaaat	6	8	1	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr14:60945101C>A	uc001xez.3	-	5	350	c.240G>T	c.(238-240)AAG>AAT	p.K80N	C14orf39_uc010apo.2_Intron	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	80										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		CACATGTTGGCTTCCAGCTAT	0.259													A	60945101	A	A	60945101	3	1	180	1	0	0	0	0	1	0	0	0	1772	796	28	5	1579	5	C14orf39	14	60945101	Missense_Mutation	SNP	C	TCGA-26-6173-01A-11D-1845-08		60945101	46404439	34	12801											
ZFP36L1	677	broad.mit.edu	37	chr14	69256954	69256954	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgacctggccgcccccggGctgcttctgggtgggcagca	16	14	1	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr14:69256954G>A	uc001xkh.1	-	2	443	c.313C>T	c.(313-315)CCC>TCC	p.P105S	ZFP36L1_uc001xki.1_Missense_Mutation_p.P105S	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	105					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CCGCCCCCGGGCTGCTTCTGG	0.672											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	69256954	A	A	69256954	3	1	180	1	0	0	0	0	1	0	0	0	17643	1203	42	3	707	3	ZFP36L1	14	69256954	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08	8311853	69256954	38092586	35	12802											
ACAN	176	broad.mit.edu	37	chr15	89386651	89386651	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagcagccaatgagtgccggCggctgggtgcccggctggcc	17	13	0	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr15:89386651C>T	uc010upo.1	+	6	1197	c.823C>T	c.(823-825)CGG>TGG	p.R275W	ACAN_uc002bmx.2_Missense_Mutation_p.R275W|ACAN_uc010upp.1_Missense_Mutation_p.R275W|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	275					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGAGTGCCGGCGGCTGGGTGC	0.642													T	89386651	T	T	89386651	3	4	180	1	0	0	0	0	1	0	0	0	117	759	27	1	841	1	ACAN	15	89386651	Missense_Mutation	SNP	C	TCGA-26-6173-01A-11D-1845-08		89386651	13144741	36	12803											
AMDHD2	51005	broad.mit.edu	37	chr16	2580611	2580611	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgggcacaggaggtacgCgcctggctctgccactgttc	13	14	1	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr16:2580611C>T	uc010uwc.1	+	11	1733	c.1636C>T	c.(1636-1638)CGC>TGC	p.R546C	AMDHD2_uc010uwd.1_Missense_Mutation_p.R310C|CEMP1_uc002cqr.2_Missense_Mutation_p.R155H	NM_001145815	NP_001139287	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 2	Error:Variant_position_missing_in_Q9Y303_after_alignment					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			skin(2)|large_intestine(1)|breast(1)	4						AGGAGGTACGCGCCTGGCTCT	0.567													T	2580611	T	T	2580611	3	4	180	1	0	0	0	0	1	0	0	0	568	768	27	1	1716	1	AMDHD2	16	2580611	Missense_Mutation	SNP	C	TCGA-26-6173-01A-11D-1845-08		2580611	87774142	37	12804											
ATXN2L	11273	broad.mit.edu	37	chr16	28847275	28847275	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cccatgtccaaactggaatcAcagcagccccgccccctcac	6	20	2	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr16:28847275A>T	uc002drc.2	+	22	3085	c.2917A>T	c.(2917-2919)ACA>TCA	p.T973S	uc010vct.1_Intron|ATXN2L_uc002drb.2_Missense_Mutation_p.T973S|ATXN2L_uc002dqy.2_Missense_Mutation_p.T973S|ATXN2L_uc002dra.2_Missense_Mutation_p.T973S|ATXN2L_uc002dqz.2_Missense_Mutation_p.T973S|ATXN2L_uc010vdb.1_Missense_Mutation_p.T979S|ATXN2L_uc002dre.2_Missense_Mutation_p.T973S|ATXN2L_uc002drf.2_Missense_Mutation_p.T382S|ATXN2L_uc002drg.2_Missense_Mutation_p.T256S	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	973						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						AACTGGAATCACAGCAGCCCC	0.622													T	28847275	T	T	28847275	3	4	180	1	0	0	0	0	1	0	0	0	1212	159	6	5	3003	5	ATXN2L	16	28847275	Missense_Mutation	SNP	A	TCGA-26-6173-01A-11D-1845-08	26266664	28847275	61507478	38	12805											
MYH8	4626	broad.mit.edu	37	chr17	10304645	10304645	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttggtcaggatgttgacttTgtcctcctctgcctgcaggt	11	10	2	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr17:10304645T>A	uc002gmm.2	-	24	3150	c.3055A>T	c.(3055-3057)AAA>TAA	p.K1019*	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1019	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATGTTGACTTTGTCCTCCTCT	0.438									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				A	10304645	A	A	10304645	4	1	180	1	0	0	0	0	0	1	0	0	10041	1821	63	5	2826	5	MYH8	17	10304645	Nonsense_Mutation	SNP	T	TCGA-26-6173-01A-11D-1845-08		10304645	70890565	39	12806											
NLE1	54475	broad.mit.edu	37	chr17	33463392	33463392	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcactcacaggatccttggAggtcttggggattaactgag	12	8	3	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr17:33463392A>G	uc002hiy.1	-	8	981	c.953T>C	c.(952-954)CTC>CCC	p.L318P	NLE1_uc010ctn.1_Missense_Mutation_p.L26P|NLE1_uc002hiz.1_Missense_Mutation_p.L26P	NM_018096	NP_060566	Q9NVX2	NLE1_HUMAN	Notchless gene homolog isoform a	318						nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)				GGATCCTTGGAGGTCTTGGGG	0.567													G	33463392	G	G	33463392	3	3	180	1	0	0	0	0	1	0	0	0	10460	304	11	4	528	4	NLE1	17	33463392	Missense_Mutation	SNP	A	TCGA-26-6173-01A-11D-1845-08	23158747	33463392	47731818	40	12807											
EPX	8288	broad.mit.edu	37	chr17	56270743	56270743	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgggcagcatcaagcagcGgcttcgcagcggttcagcca	13	14	2	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr17:56270743G>A	uc002ivq.2	+	3	268	c.182G>A	c.(181-183)CGG>CAG	p.R61Q		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	61					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						ATCAAGCAGCGGCTTCGCAGC	0.612													A	56270743	A	A	56270743	3	1	180	1	0	0	0	0	1	0	0	0	5200	1116	39	2	192	2	EPX	17	56270743	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08	22807351	56270743	24924467	41	12808											
XAB2	56949	broad.mit.edu	37	chr19	7687257	7687257	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acttgtgctcctccaggaacAtggcatagttgatgacgatc	10	10	0	2			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr19:7687257A>G	uc002mgx.2	-	12	1603	c.1577T>C	c.(1576-1578)ATG>ACG	p.M526T		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	526	HAT 10.				transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						CTCCAGGAACATGGCATAGTT	0.607								Direct_reversal_of_damage|NER					G	7687257	G	G	7687257	3	3	180	1	0	0	0	0	1	0	0	0	17415	217	8	4	1022	4	XAB2	19	7687257	Missense_Mutation	SNP	A	TCGA-26-6173-01A-11D-1845-08		7687257	51441726	42	12809											
NDUFA3	4696	broad.mit.edu	37	chr19	54609317	54609317	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccacgccctacaactacccAggtgagtgggggccaggcag	14	14	0	1			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr19:54609317A>C	uc002qde.2	+	3	189	c.162A>C	c.(160-162)CCA>CCC	p.P54P	NDUFA3_uc002qdf.2_RNA	NM_004542	NP_004533	O95167	NDUA3_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	54					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)	1	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)				NADH(DB00157)	ACAACTACCCAGGTGAGTGGG	0.577													C	54609317	C	C	54609317	2	2	180	1	0	0	0	0	0	0	0	1	10265	202	7	5		5	NDUFA3	19	54609317	Silent	SNP	A	TCGA-26-6173-01A-11D-1845-08	46922060	54609317	4519666	43	12810											
ZNF497	162968	broad.mit.edu	37	chr19	58868065	58868065	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgcaggagctgcgagctctCgcggaaagcctttccgcact	12	14	1	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr19:58868065C>T	uc002qsh.1	-	3	1126	c.937G>A	c.(937-939)GAG>AAG	p.E313K	A1BG_uc002qsf.1_Intron|ZNF497_uc002qsi.1_Missense_Mutation_p.E313K|uc002qsj.1_5'Flank|uc002qsk.1_5'Flank	NM_198458	NP_940860	Q6ZNH5	ZN497_HUMAN	zinc finger protein 497	313	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0278)		TGCGAGCTCTCGCGGAAAGCC	0.701													T	58868065	T	T	58868065	3	4	180	1	0	0	0	0	1	0	0	0	17943	893	31	2	563	2	ZNF497	19	58868065	Missense_Mutation	SNP	C	TCGA-26-6173-01A-11D-1845-08	4258748	58868065	260918	44	12811											
NTSR1	4923	broad.mit.edu	37	chr20	61340986	61340986	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcggcgacgccggctgccgcGgctactacttcctgcgcgac	13	17	0	0			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr20:61340986G>A	uc002ydf.2	+	1	798	c.427G>A	c.(427-429)GGC>AGC	p.G143S		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	143	Helical; Name=3; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CGGCTGCCGCGGCTACTACTT	0.677													A	61340986	A	A	61340986	3	1	180	1	0	0	0	0	1	0	0	0	10710	1116	39	2	429	2	NTSR1	20	61340986	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08		61340986	1684534	45	12812											
EP300	2033	broad.mit.edu	37	chr22	41556657	41556657	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccgacaggtatcatttctGtgagaagtgtttcaatgaga	11	6	3	2			TCGA-26-6173-01A-11D-1845-08	TCGA-26-6173-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	af373e42-cbbf-4a89-8479-bdd413011885	e7628017-ae1e-4937-856e-d47378745937	g.chr22:41556657G>A	uc003azl.3	+	20	3997	c.3602G>A	c.(3601-3603)TGT>TAT	p.C1201Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1201					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.Y1198_L1243del(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TATCATTTCTGTGAGAAGTGT	0.488			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				A	41556657	A	A	41556657	3	1	180	1	0	0	0	0	1	0	0	0	5148	1377	48	3	3680	3	EP300	22	41556657	Missense_Mutation	SNP	G	TCGA-26-6173-01A-11D-1845-08		41556657	9747909	46	12813											
EPHB2	2048	broad.mit.edu	37	chr1	23111326	23111326	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcatgtccctcatcgccGtgcgtgtcttctaccgcaag	10	15	3	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr1:23111326G>A	uc009vqj.1	+	3	713	c.568G>A	c.(568-570)GTG>ATG	p.V190M	EPHB2_uc001bge.2_Missense_Mutation_p.V190M|EPHB2_uc001bgf.2_Missense_Mutation_p.V190M|EPHB2_uc010odu.1_Missense_Mutation_p.V190M	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	190	Extracellular (Potential).|Cys-rich.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CCTCATCGCCGTGCGTGTCTT	0.622									Hereditary_Prostate_Cancer				A	23111326	A	A	23111326	3	1	181	1	0	0	0	0	1	0	0	0	5175	1145	40	1	578	1	EPHB2	1	23111326	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		23111326	226139295	1	12814											
PTPRU	10076	broad.mit.edu	37	chr1	29606627	29606627	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcaccgtgctgctgaggccGgcacagggccgcggtgcgcc	16	15	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr1:29606627G>A	uc001bru.2	+	11	1952	c.1842G>A	c.(1840-1842)CCG>CCA	p.P614P	PTPRU_uc001brv.2_Silent_p.P614P|PTPRU_uc001brw.2_Silent_p.P614P|PTPRU_uc009vtq.2_Silent_p.P614P|PTPRU_uc009vtr.2_Silent_p.P614P	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	614	Extracellular (Potential).|Fibronectin type-III 4.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		TGCTGAGGCCGGCACAGGGCC	0.652													A	29606627	A	A	29606627	2	1	181	1	0	0	0	0	0	0	0	1	12813	1103	39	2		2	PTPRU	1	29606627	Silent	SNP	G	TCGA-26-6174-01A-21D-1845-08	6495301	29606627	219643994	2	12815											
RPL5	6125	broad.mit.edu	37	chr1	93298990	93298990	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaggcctactttaagagataCcaagtgaaatttagaagacg	9	6	0	4	rs148673599	byFrequency	TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr1:93298990C>A	uc001doz.2	+	2	126	c.48C>A	c.(46-48)TAC>TAA	p.Y16*	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_RNA|RPL5_uc001dpb.2_5'UTR|RPL5_uc001dpd.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5	16					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		TTAAGAGATACCAAGTGAAAT	0.318													A	93298990	A	A	93298990	4	1	181	1	0	0	0	0	0	1	0	0	13597	518	18	5	54	5	RPL5	1	93298990	Nonsense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	63692363	93298990	155951631	3	12816											
SYCP1	6847	broad.mit.edu	37	chr1	115401212	115401212	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tattcaaaactgtataaggaGgctgaaaagataaaaaaatg	8	3	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr1:115401212G>A	uc001efr.2	+	6	545	c.336G>A	c.(334-336)GAG>GAA	p.E112E	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Silent_p.E112E|SYCP1_uc009wgw.2_Silent_p.E112E	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	112	Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGTATAAGGAGGCTGAAAAGA	0.303													A	115401212	A	A	115401212	2	1	181	1	0	0	0	0	0	0	0	1	15428	991	35	3		3	SYCP1	1	115401212	Silent	SNP	G	TCGA-26-6174-01A-21D-1845-08	22102222	115401212	133849409	4	12817											
SPAG17	200162	broad.mit.edu	37	chr1	118524021	118524021	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgaaaccttatgtggcttgAaatctagaaaacccaaaatg	7	8	1	3			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr1:118524021A>G	uc001ehk.2	-	43	5944	c.5876T>C	c.(5875-5877)TTC>TCC	p.F1959S		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1959						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ATGTGGCTTGAAATCTAGAAA	0.338													G	118524021	G	G	118524021	3	3	181	1	0	0	0	0	1	0	0	0	14979	246	9	4	819	4	SPAG17	1	118524021	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08	3122809	118524021	130726600	5	12818											
CRP	1401	broad.mit.edu	37	chr1	159683681	159683681	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gctactgtgacttcaggaacCtcgaataatatttcagaccc	7	11	2	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr1:159683681C>A	uc001ftw.2	-	2	413	c.309G>T	c.(307-309)GAG>GAT	p.E103D	CRP_uc001ftx.1_Intron|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	103	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding	p.E103K(1)		ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	CTTCAGGAACCTCGAATAATA	0.468													A	159683681	A	A	159683681	3	1	181	1	0	0	0	0	1	0	0	0	3895	680	24	5	369	5	CRP	1	159683681	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	41159660	159683681	89566940	6	12819											
UHMK1	127933	broad.mit.edu	37	chr1	162492275	162492275	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggatgtttgatgggaagtttGttgtggctacattctacccg	13	6	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr1:162492275G>C	uc001gcc.1	+	8	1331	c.1195G>C	c.(1195-1197)GTT>CTT	p.V399L	UHMK1_uc001gcb.1_Missense_Mutation_p.V325L|UHMK1_uc009wuu.1_3'UTR|uc001gcd.2_5'Flank	NM_175866	NP_787062	Q8TAS1	UHMK1_HUMAN	kinase interacting stathmin	399	RRM.				cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding				0	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TGGGAAGTTTGTTGTGGCTAC	0.423													C	162492275	C	C	162492275	3	2	181	1	0	0	0	0	1	0	0	0	16963	1377	48	5	1275	5	UHMK1	1	162492275	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	2808594	162492275	86758346	7	12820											
C1orf125	126859	broad.mit.edu	37	chr1	179399690	179399690	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatggaagagtctacaagcgAgacactgaaaattgttaagg	11	5	1	3			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr1:179399690A>C	uc001gmo.2	+	14	1563	c.1436A>C	c.(1435-1437)GAG>GCG	p.E479A	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Missense_Mutation_p.E267A|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.E479A	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	479	Potential.										0						TCTACAAGCGAGACACTGAAA	0.368													C	179399690	C	C	179399690	3	2	181	1	0	0	0	0	1	0	0	0	1993	304	11	5	1486	5	C1orf125	1	179399690	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08	16907415	179399690	69850931	8	12821											
TDRD5	163589	broad.mit.edu	37	chr1	179620128	179620128	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtgtgacacatcctcaaacGaagatgtctatttccatcat	6	10	3	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr1:179620128G>A	uc001gnf.1	+	12	2177	c.1927G>A	c.(1927-1929)GAA>AAA	p.E643K	TDRD5_uc010pnp.1_Missense_Mutation_p.E643K|TDRD5_uc001gnh.1_Missense_Mutation_p.E198K	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	643					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						ATCCTCAAACGAAGATGTCTA	0.413													A	179620128	A	A	179620128	3	1	181	1	0	0	0	0	1	0	0	0	15730	1059	37	2	1969	2	TDRD5	1	179620128	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	220438	179620128	69630493	9	12822											
EHD3	30845	broad.mit.edu	37	chr2	31483756	31483756	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgctgccctgcgcaagctcAacgacctcatcaaaagggcc	9	15	3	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr2:31483756A>G	uc002rnu.2	+	4	1491	c.883A>G	c.(883-885)AAC>GAC	p.N295D	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	295					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					GCGCAAGCTCAACGACCTCAT	0.622													G	31483756	G	G	31483756	3	3	181	1	0	0	0	0	1	0	0	0	4979	130	5	4	897	4	EHD3	2	31483756	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08		31483756	211715617	10	12823											
NCAPH	23397	broad.mit.edu	37	chr2	97035182	97035182	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gcctgccccctgtcatggctCagaacctctccatacctctg	7	18	4	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr2:97035182C>A	uc002svz.1	+	17	2194	c.2110C>A	c.(2110-2112)CAG>AAG	p.Q704K	NCAPH_uc010yum.1_Missense_Mutation_p.Q680K|NCAPH_uc010fhw.1_Missense_Mutation_p.Q693K|NCAPH_uc010yun.1_Missense_Mutation_p.Q568K|NCAPH_uc002swa.1_Missense_Mutation_p.Q299K	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	704					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				TGTCATGGCTCAGAACCTCTC	0.438													A	97035182	A	A	97035182	3	1	181	1	0	0	0	0	1	0	0	0	10209	827	29	5	2176	5	NCAPH	2	97035182	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	65551426	97035182	146164191	11	12824											
SP3	6670	broad.mit.edu	37	chr2	174783399	174783399	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcttgatgttgttggtccCcttcttcatctaccacctgt	6	13	4	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr2:174783399C>T	uc002uig.2	-	5	1918	c.1754G>A	c.(1753-1755)GGG>GAG	p.G585E	SP3_uc002uie.2_Missense_Mutation_p.G517E|SP3_uc002uif.2_Missense_Mutation_p.G532E|SP3_uc010zel.1_Missense_Mutation_p.G582E	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	585	Repressor domain.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TTGTTGGTCCCCTTCTTCATC	0.448													T	174783399	T	T	174783399	3	4	181	1	0	0	0	0	1	0	0	0	14965	623	22	3	603	3	SP3	2	174783399	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	77748217	174783399	68415974	12	12825											
TTN	7273	broad.mit.edu	37	chr2	179483009	179483009	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cacacggaataggtactcaaCtcctcctttctgtagaccag	7	13	2	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr2:179483009C>A	uc010zfg.1	-	201	39696	c.39472G>T	c.(39472-39474)GTT>TTT	p.V13158F	TTN_uc010zfh.1_Missense_Mutation_p.V6853F|TTN_uc010zfi.1_Missense_Mutation_p.V6786F|TTN_uc010zfj.1_Missense_Mutation_p.V6661F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14085							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGTACTCAACTCCTCCTTTC	0.458													A	179483009	A	A	179483009	3	1	181	1	0	0	0	0	1	0	0	0	16732	565	20	5	60961	5	TTN	2	179483009	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	4699610	179483009	63716364	13	12826											
TTN	7273	broad.mit.edu	37	chr2	179650718	179650718	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctcagctacctttgcggCggaaatgcgttccttatatc	10	11	1	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr2:179650718C>T	uc010zfg.1	-	14	2451	c.2227G>A	c.(2227-2229)GCC>ACC	p.A743T	TTN_uc010zfh.1_Missense_Mutation_p.A697T|TTN_uc010zfi.1_Missense_Mutation_p.A697T|TTN_uc010zfj.1_Missense_Mutation_p.A697T|TTN_uc002unb.2_Missense_Mutation_p.A743T|TTN_uc010frg.1_Missense_Mutation_p.A325T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	743							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTTGCGGCGGAAATGCGT	0.547													T	179650718	T	T	179650718	3	4	181	1	0	0	0	0	1	0	0	0	16732	768	27	1	109157	1	TTN	2	179650718	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	167709	179650718	63548655	14	12827											
THAP4	51078	broad.mit.edu	37	chr2	242576398	242576398	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctcgccctttccctgccggTtggagcagttcacggccgca	11	16	2	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr2:242576398T>C	uc002wbt.2	-	1	258	c.35A>G	c.(34-36)AAC>AGC	p.N12S	ATG4B_uc002wbu.2_5'Flank|ATG4B_uc002wbv.2_5'Flank|ATG4B_uc002wbw.2_5'Flank|ATG4B_uc010zox.1_5'Flank|ATG4B_uc010zoy.1_5'Flank|ATG4B_uc010fzp.2_5'Flank	NM_015963	NP_057047	Q8WY91	THAP4_HUMAN	THAP domain containing 4 isoform 1	12	THAP-type.						DNA binding|metal ion binding				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		TCCCTGCCGGTTGGAGCAGTT	0.418													C	242576398	C	C	242576398	3	2	181	1	0	0	0	0	1	0	0	0	15843	1725	60	4	1730	4	THAP4	2	242576398	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08	62925680	242576398	622975	15	12828											
ITGA9	3680	broad.mit.edu	37	chr3	37583996	37583996	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tctactttgtgctgctgggaGagaccatgggtcaggtcaca	13	9	3	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr3:37583996G>A	uc003chd.2	+	15	1662	c.1609G>A	c.(1609-1611)GAG>AAG	p.E537K	ITGA9_uc003chc.2_Missense_Mutation_p.E537K	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	537	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GCTGCTGGGAGAGACCATGGG	0.527													A	37583996	A	A	37583996	3	1	181	1	0	0	0	0	1	0	0	0	7883	943	33	3	1667	3	ITGA9	3	37583996	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		37583996	160438434	16	12829											
SCN10A	6336	broad.mit.edu	37	chr3	38835414	38835414	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctttgttccctgcttggCagcaatttgcttctctatct	6	11	3	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr3:38835414C>T	uc003ciq.2	-	1	88	c.88G>A	c.(88-90)GCC>ACC	p.A30T		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	30					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCCTGCTTGGCAGCAATTTGC	0.507													T	38835414	T	T	38835414	3	4	181	1	0	0	0	0	1	0	0	0	13912	710	25	3	5890	3	SCN10A	3	38835414	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	1251418	38835414	159187016	17	12830											
EPHA3	2042	broad.mit.edu	37	chr3	89259060	89259060	+	Nonsense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tacacacccatcaggacttaCcaggtgtgcaatgtcatgga	9	11	2	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr3:89259060C>G	uc003dqy.2	+	3	429	c.204C>G	c.(202-204)TAC>TAG	p.Y68*	EPHA3_uc003dqx.1_Nonsense_Mutation_p.Y68*|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	68	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TCAGGACTTACCAGGTGTGCA	0.438										TSP Lung(6;0.00050)			G	89259060	G	G	89259060	4	3	181	1	0	0	0	0	0	1	0	0	5168	518	18	5	214	5	EPHA3	3	89259060	Nonsense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	50423646	89259060	108763370	18	12831											
OR5H1	26341	broad.mit.edu	37	chr3	97852369	97852369	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caagatatggtggagcctctAttctacactgtcatcattcc	7	11	4	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr3:97852369A>G	uc011bgt.1	+	1	828	c.828A>G	c.(826-828)CTA>CTG	p.L276L		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TGGAGCCTCTATTCTACACTG	0.388													G	97852369	G	G	97852369	2	3	181	1	0	0	0	0	0	0	0	1	11159	436	16	4		4	OR5H1	3	97852369	Silent	SNP	A	TCGA-26-6174-01A-21D-1845-08	8593309	97852369	100170061	19	12832											
PARP9	83666	broad.mit.edu	37	chr3	122271392	122271392	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctttgtggcaagaaattccGatttcatttcaactcctgct	6	11	2	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr3:122271392G>A	uc010hri.2	-	5	1230	c.1085C>T	c.(1084-1086)TCG>TTG	p.S362L	PARP9_uc003eff.3_Missense_Mutation_p.S327L|PARP9_uc011bjs.1_Missense_Mutation_p.S327L|PARP9_uc003efg.2_Intron|PARP9_uc003efi.2_Missense_Mutation_p.S327L|PARP9_uc003efh.2_Missense_Mutation_p.S362L|PARP9_uc003efj.2_Missense_Mutation_p.S327L	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	362	Macro 2.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		AAGAAATTCCGATTTCATTTC	0.373													A	122271392	A	A	122271392	3	1	181	1	0	0	0	0	1	0	0	0	11466	1059	37	2	1560	2	PARP9	3	122271392	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	24419023	122271392	75751038	20	12833											
CPNE4	131034	broad.mit.edu	37	chr3	131261494	131261494	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcccatcatcaccgtccagCatctgcatgtcactgaagtc	6	15	4	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr3:131261494C>T	uc003eok.2	-	15	1881	c.1446G>A	c.(1444-1446)ATG>ATA	p.M482I	CPNE4_uc011blq.1_Missense_Mutation_p.M500I|CPNE4_uc003eol.2_Missense_Mutation_p.M500I|CPNE4_uc003eom.2_Missense_Mutation_p.M482I|CPNE4_uc003eoj.2_Missense_Mutation_p.M33I	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	482	VWFA.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CACCGTCCAGCATCTGCATGT	0.557													T	131261494	T	T	131261494	3	4	181	1	0	0	0	0	1	0	0	0	3814	710	25	3	235	3	CPNE4	3	131261494	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	8990102	131261494	66760936	21	12834											
NPHP3	27031	broad.mit.edu	37	chr3	132413753	132413754	+	Frame_Shift_Ins	INS	-	C	C													tctatataatgaaagagtatINScttgacactggaaacactga							TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr3:132413753_132413754insC	uc003epe.1	-	16	2304_2305	c.2227_2228insG	c.(2227-2229)GATfs	p.D743fs	NPHP3_uc003epd.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	743					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						TGAAAGAGTATCTTGACACTGG	0.381													C	132413754	C	C	132413753	7	5	181	1	0	1	1	0	0	0	0	0	10580	1435	50	0	1812	0	NPHP3	3	132413753	Frame_Shift_Ins	INS	-	TCGA-26-6174-01A-21D-1845-08	1152259	132413753	65608677	22	12835											
ALG3	10195	broad.mit.edu	37	chr3	183961666	183961666	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggctcgatgcaggaagagcGcctctgggaggaagcgccag	17	10	1	1	rs2233466	by1000genomes	TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr3:183961666G>A	uc003fne.2	-	6	876	c.845C>T	c.(844-846)GCG>GTG	p.A282V	ALG3_uc011brc.1_Missense_Mutation_p.A247V|ALG3_uc011brd.1_Missense_Mutation_p.A226V|ALG3_uc011bre.1_Missense_Mutation_p.A234V|ALG3_uc003fnf.1_Missense_Mutation_p.A242V	NM_005787	NP_005778	Q92685	ALG3_HUMAN	alpha-1,3-mannosyltransferase ALG3 isoform a	282					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity				0	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CAGGAAGAGCGCCTCTGGGAG	0.612													A	183961666	A	A	183961666	3	1	181	1	0	0	0	0	1	0	0	0	520	1087	38	1	487	1	ALG3	3	183961666	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	51547913	183961666	14060764	23	12836											
CDKL2	8999	broad.mit.edu	37	chr4	76522320	76522320	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtcatggagacagctggcaTttgaagctctattgcctttt	10	8	2	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr4:76522320T>C	uc003hiq.2	-	9	1646	c.1121A>G	c.(1120-1122)AAT>AGT	p.N374S	CDKL2_uc011cbp.1_Missense_Mutation_p.N374S	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	374					sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ACAGCTGGCATTTGAAGCTCT	0.393													C	76522320	C	C	76522320	3	2	181	1	0	0	0	0	1	0	0	0	3154	1493	52	4	372	4	CDKL2	4	76522320	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08		76522320	114631956	24	12837											
THAP9	79725	broad.mit.edu	37	chr4	83825996	83825996	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	accaggtgctatactgtgttCcaaacattttcaagaaagtg	8	8	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr4:83825996C>G	uc003hnt.2	+	2	307	c.188C>G	c.(187-189)TCC>TGC	p.S63C	THAP9_uc003hns.1_5'UTR|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_5'UTR	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	63	THAP-type.						DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				ATACTGTGTTCCAAACATTTT	0.403													G	83825996	G	G	83825996	3	3	181	1	0	0	0	0	1	0	0	0	15848	855	30	5	194	5	THAP9	4	83825996	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	7303676	83825996	107328280	25	12838											
DDX60L	91351	broad.mit.edu	37	chr4	169279395	169279395	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgccaggactacattgtcaCgcttattttcacatagttca	6	10	3	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr4:169279395C>T	uc003irq.3	-	38	5245	c.5024G>A	c.(5023-5025)CGT>CAT	p.R1675H		NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1675							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TACATTGTCACGCTTATTTTC	0.264													T	169279395	T	T	169279395	3	4	181	1	0	0	0	0	1	0	0	0	4379	536	19	1	100	1	DDX60L	4	169279395	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	85453399	169279395	21874881	26	12839											
MYO10	4651	broad.mit.edu	37	chr5	16877810	16877810	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attttctctcagccagacccGtgttccctgtaaacaaaaca	5	13	2	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr5:16877810G>A	uc003jft.3	-	2	496	c.28C>T	c.(28-30)CGG>TGG	p.R10W	MYO10_uc003jfu.2_Intron|MYO10_uc003jfv.2_Missense_Mutation_p.R10W	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	10	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						AGCCAGACCCGTGTTCCCTGT	0.438													A	16877810	A	A	16877810	3	1	181	1	0	0	0	0	1	0	0	0	10062	1144	40	1	6308	1	MYO10	5	16877810	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		16877810	164037450	27	12840											
PARP8	79668	broad.mit.edu	37	chr5	50091080	50091080	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtaatctcagaatggaagaAttatatggactgaaaaatca	8	4	2	3			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr5:50091080A>G	uc003jon.3	+	13	1439	c.1257A>G	c.(1255-1257)GAA>GAG	p.E419E	PARP8_uc011cpz.1_Silent_p.E311E|PARP8_uc003joo.2_Silent_p.E419E|PARP8_uc003jop.2_Silent_p.E419E	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	419						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GAATGGAAGAATTATATGGAC	0.438													G	50091080	G	G	50091080	2	3	181	1	0	0	0	0	0	0	0	1	11465	98	4	4		4	PARP8	5	50091080	Silent	SNP	A	TCGA-26-6174-01A-21D-1845-08	33213270	50091080	130824180	28	12841											
DDX4	54514	broad.mit.edu	37	chr5	55083703	55083703	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcctaccaattttggctcaTatgatgcatgatggaataac	7	9	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr5:55083703T>C	uc003jqg.3	+	15	1121	c.1047T>C	c.(1045-1047)CAT>CAC	p.H349H	DDX4_uc010ivz.2_Silent_p.H329H|DDX4_uc003jqh.3_Silent_p.H315H|DDX4_uc003jqj.2_Silent_p.H200H	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	349	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TTTTGGCTCATATGATGCATG	0.383													C	55083703	C	C	55083703	2	2	181	1	0	0	0	0	0	0	0	1	4360	1403	49	4		4	DDX4	5	55083703	Silent	SNP	T	TCGA-26-6174-01A-21D-1845-08	4992623	55083703	125831557	29	12842											
MAST4	375449	broad.mit.edu	37	chr5	66460727	66460727	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaaaggtccccatcctactgCcaggagccctggaacagtca	10	14	1	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr5:66460727C>A	uc003jut.1	+	28	5221	c.5153C>A	c.(5152-5154)GCC>GAC	p.A1718D	MAST4_uc003juw.2_Missense_Mutation_p.A1646D|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1910						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CATCCTACTGCCAGGAGCCCT	0.582													A	66460727	A	A	66460727	3	1	181	1	0	0	0	0	1	0	0	0	9327	739	26	5	5964	5	MAST4	5	66460727	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	11377024	66460727	114454533	30	12843											
PIK3R1	5295	broad.mit.edu	37	chr5	67591145	67591145	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgagaaagacgagagaccaaTacttgatgtaagtatttgaa	10	4	0	5			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr5:67591145T>G	uc003jva.2	+	13	2298	c.1738T>G	c.(1738-1740)TAC>GAC	p.Y580D	PIK3R1_uc003jvb.2_Missense_Mutation_p.Y580D|PIK3R1_uc003jvc.2_Missense_Mutation_p.Y280D|PIK3R1_uc003jvd.2_Missense_Mutation_p.Y310D|PIK3R1_uc003jve.2_Missense_Mutation_p.Y259D|PIK3R1_uc011crb.1_Missense_Mutation_p.Y250D	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	580					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.R577_M582>K(1)|p.Y580fs*1(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GAGAGACCAATACTTGATGTA	0.368			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			G	67591145	G	G	67591145	3	3	181	1	0	0	0	0	1	0	0	0	11918	1406	49	5	1914	5	PIK3R1	5	67591145	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08	1130418	67591145	113324115	31	12844											
PCDHA3	56145	broad.mit.edu	37	chr5	140182250	140182250	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acgcgcaggagaacgccctgGtgtcctactcgctggtggaa	14	12	0	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr5:140182250G>C	uc003lhf.2	+	1	1468	c.1468G>C	c.(1468-1470)GTG>CTG	p.V490L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.V490L	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	490	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACGCCCTGGTGTCCTACTC	0.677													C	140182250	C	C	140182250	3	2	181	1	0	0	0	0	1	0	0	0	11525	1261	44	5	1470	5	PCDHA3	5	140182250	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	72591105	140182250	40733010	32	12845											
PCDHA13	56136	broad.mit.edu	37	chr5	140263908	140263908	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgtcgagggcgtcggcaggCgctgtgggtccagaagcggc	19	11	0	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr5:140263908C>T	uc003lif.2	+	1	2055	c.2055C>T	c.(2053-2055)GGC>GGT	p.G685G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.G685G|PCDHA13_uc003lid.2_Silent_p.G685G	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	685	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTCGGCAGGCGCTGTGGGTC	0.632													T	140263908	T	T	140263908	2	4	181	1	0	0	0	0	0	0	0	1	11523	755	27	1		1	PCDHA13	5	140263908	Silent	SNP	C	TCGA-26-6174-01A-21D-1845-08	81658	140263908	40651352	33	12846											
KIF4B	285643	broad.mit.edu	37	chr5	154393521	154393521	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgccagatgtgcctttccttCgtgcccggggagactcaggt	13	12	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr5:154393521C>T	uc010jih.1	+	1	262	c.102C>T	c.(100-102)TTC>TTT	p.F34F		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	34	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GCCTTTCCTTCGTGCCCGGGG	0.512													T	154393521	T	T	154393521	2	4	181	1	0	0	0	0	0	0	0	1	8304	883	31	2		2	KIF4B	5	154393521	Silent	SNP	C	TCGA-26-6174-01A-21D-1845-08	14129613	154393521	26521739	34	12847											
ADAMTS2	9509	broad.mit.edu	37	chr5	178579165	178579165	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccaggtgcacacatagtcCcgtccaaggggggccccttc	12	15	0	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr5:178579165C>T	uc003mjw.2	-	10	1607	c.1607G>A	c.(1606-1608)GGG>GAG	p.G536E	ADAMTS2_uc011dgm.1_Missense_Mutation_p.G536E	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	536	Disintegrin.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		ACACATAGTCCCGTCCAAGGG	0.602													T	178579165	T	T	178579165	3	4	181	1	0	0	0	0	1	0	0	0	265	623	22	3	2155	3	ADAMTS2	5	178579165	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	24185644	178579165	2336095	35	12848											
COL11A2	1302	broad.mit.edu	37	chr6	33132163	33132163	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tccagagcaggggtaggagaCgtcctggtgggctgagacgc	18	9	0	3			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr6:33132163C>A	uc003ocx.1	-	65	5179	c.4951G>T	c.(4951-4953)GTC>TTC	p.V1651F	COL11A2_uc010jul.1_Missense_Mutation_p.V221F|COL11A2_uc003ocy.1_Missense_Mutation_p.V1565F|COL11A2_uc003ocz.1_Missense_Mutation_p.V1544F	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1651	Fibrillar collagen NC1.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GGGTAGGAGACGTCCTGGTGG	0.622													A	33132163	A	A	33132163	3	1	181	1	0	0	0	0	1	0	0	0	3668	536	19	5	267	5	COL11A2	6	33132163	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08		33132163	137982904	36	12849											
C6orf127	340204	broad.mit.edu	37	chr6	35754829	35754829	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgagactggctgctgccaaCgtgctccagacaattgcgag	13	12	0	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr6:35754829C>T	uc003old.3	+	2	211	c.154C>T	c.(154-156)CGT>TGT	p.R52C		NM_001010886	NP_001010886	A2RUU4	CF127_HUMAN	hypothetical protein LOC340204 precursor	52					digestion|lipid catabolic process	extracellular region	enzyme activator activity			skin(1)	1						CTGCTGCCAACGTGCTCCAGA	0.672													T	35754829	T	T	35754829	3	4	181	1	0	0	0	0	1	0	0	0	2327	536	19	1	160	1	C6orf127	6	35754829	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	2622666	35754829	135360238	37	12850											
KHDRBS2	202559	broad.mit.edu	37	chr6	62407128	62407128	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcataggcatcctcacttacTccatgaccgtagtcatagta	6	12	3	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr6:62407128T>C	uc003peg.2	-	8	1171	c.924A>G	c.(922-924)GGA>GGG	p.G308G		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	308					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		CCTCACTTACTCCATGACCGT	0.378													C	62407128	C	C	62407128	2	2	181	1	0	0	0	0	0	0	0	1	8147	1538	54	4		4	KHDRBS2	6	62407128	Silent	SNP	T	TCGA-26-6174-01A-21D-1845-08	26652299	62407128	108707939	38	12851											
EYS	346007	broad.mit.edu	37	chr6	66094367	66094367	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggtcaattgctttctcacagTttttttcagtaaatcctgat	6	8	3	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr6:66094367T>A	uc011dxu.1	-	8	1749	c.1211A>T	c.(1210-1212)AAC>ATC	p.N404I	EYS_uc003peq.2_Missense_Mutation_p.N404I|EYS_uc003per.1_Missense_Mutation_p.N404I	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	404	EGF-like 5.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						TTTCTCACAGTTTTTTTCAGT	0.284													A	66094367	A	A	66094367	3	1	181	1	0	0	0	0	1	0	0	0	5332	1725	60	5	8329	5	EYS	6	66094367	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08	3687239	66094367	105020700	39	12852											
NT5E	4907	broad.mit.edu	37	chr6	86203654	86203654	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcaagttttccacaggaagtCactgccatggaagcttttct	8	10	3	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr6:86203654C>T	uc003pko.3	+	9	2213	c.1657C>T	c.(1657-1659)CAC>TAC	p.H553Y	NT5E_uc010kbr.2_Missense_Mutation_p.H503Y	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	553					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	CACAGGAAGTCACTGCCATGG	0.363													T	86203654	T	T	86203654	3	4	181	1	0	0	0	0	1	0	0	0	10693	826	29	3	1691	3	NT5E	6	86203654	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	20109287	86203654	84911413	40	12853											
ROS1	6098	broad.mit.edu	37	chr6	117715327	117715327	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttaacttctcggactaaccaGttcatccatgatgaaataca	5	10	2	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr6:117715327G>C	uc003pxp.1	-	10	1361	c.1162C>G	c.(1162-1164)CTG>GTG	p.L388V	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	388	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GGACTAACCAGTTCATCCATG	0.323			T	GOPC|ROS1	glioblastoma|NSCLC								C	117715327	C	C	117715327	3	2	181	1	0	0	0	0	1	0	0	0	13531	1020	36	5	6017	5	ROS1	6	117715327	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	31511673	117715327	53399740	41	12854											
CLVS2	134829	broad.mit.edu	37	chr6	123319281	123319281	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctatggcaggaagattctagTcctttttgctgccaattggg	11	8	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr6:123319281T>C	uc003pzi.1	+	2	1228	c.359T>C	c.(358-360)GTC>GCC	p.V120A		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	120	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						AAGATTCTAGTCCTTTTTGCT	0.483													C	123319281	C	C	123319281	3	2	181	1	0	0	0	0	1	0	0	0	3572	1667	58	4	361	4	CLVS2	6	123319281	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08	5603954	123319281	47795786	42	12855											
KIAA1244	57221	broad.mit.edu	37	chr6	138638494	138638494	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gatttactctttgagctgttGagagatgtgacgaaaacacc	10	7	1	4			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr6:138638494G>C	uc003qhu.2	+	27	4452	c.4452G>C	c.(4450-4452)TTG>TTC	p.L1484F		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1484					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TTGAGCTGTTGAGAGATGTGA	0.458													C	138638494	C	C	138638494	3	2	181	1	0	0	0	0	1	0	0	0	8217	1281	45	5	4558	5	KIAA1244	6	138638494	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	15319213	138638494	32476573	43	12856											
SP4	6671	broad.mit.edu	37	chr7	21469834	21469834	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctggccagtatgcaagcacaTcagccagtagttctgaacgc	10	12	2	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr7:21469834T>A	uc003sva.2	+	3	1232	c.1051T>A	c.(1051-1053)TCA>ACA	p.S351T	SP4_uc003svb.2_Missense_Mutation_p.S38T	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	351					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						TGCAAGCACATCAGCCAGTAG	0.502													A	21469834	A	A	21469834	3	1	181	1	0	0	0	0	1	0	0	0	14966	1435	50	5	1061	5	SP4	7	21469834	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08		21469834	137668829	44	12857											
DYNC1I1	1780	broad.mit.edu	37	chr7	95665015	95665015	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggagacgtcaataacttcGtggttggcagtgaggaaggt	16	6	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr7:95665015G>A	uc003uoc.3	+	13	1643	c.1366G>A	c.(1366-1368)GTG>ATG	p.V456M	DYNC1I1_uc003uod.3_Missense_Mutation_p.V439M|DYNC1I1_uc003uob.2_Missense_Mutation_p.V419M|DYNC1I1_uc003uoe.3_Missense_Mutation_p.V436M|DYNC1I1_uc010lfl.2_Missense_Mutation_p.V445M	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	456	WD 4.				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CAATAACTTCGTGGTTGGCAG	0.473													A	95665015	A	A	95665015	3	1	181	1	0	0	0	0	1	0	0	0	4842	1145	40	1	1412	1	DYNC1I1	7	95665015	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	74195181	95665015	63473648	45	12858											
SLC12A9	56996	broad.mit.edu	37	chr7	100451836	100451836	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	agccatggccagcgagagctCacctctgctggcctaccggc	12	16	2	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr7:100451836C>G	uc003uwp.2	+	2	159	c.17C>G	c.(16-18)TCA>TGA	p.S6*	SLC12A9_uc003uwo.1_Nonsense_Mutation_p.S6*|SLC12A9_uc003uwq.2_Nonsense_Mutation_p.S6*|SLC12A9_uc011kki.1_Intron|SLC12A9_uc003uwr.2_5'Flank|SLC12A9_uc003uws.2_5'Flank|SLC12A9_uc003uwt.2_5'Flank	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	6	Cytoplasmic (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					AGCGAGAGCTCACCTCTGCTG	0.632													G	100451836	G	G	100451836	4	3	181	1	0	0	0	0	0	1	0	0	14390	838	29	5	19	5	SLC12A9	7	100451836	Nonsense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	4786821	100451836	58686827	46	12859											
PLXNA4	91584	broad.mit.edu	37	chr7	131883269	131883269	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagggatgtaaccatccaCtaaagggctgcactccacgc	10	13	0	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr7:131883269C>T	uc003vra.3	-	13	2942	c.2713G>A	c.(2713-2715)GTG>ATG	p.V905M		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	905	IPT/TIG 1.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TAACCATCCACTAAAGGGCTG	0.562													T	131883269	T	T	131883269	3	4	181	1	0	0	0	0	1	0	0	0	12122	565	20	3	3051	3	PLXNA4	7	131883269	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	31431433	131883269	27255394	47	12860											
BLK	640	broad.mit.edu	37	chr8	11400849	11400849	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaggacgccccgccactgcCgcccctggtgagtgattgcc	12	17	0	2	rs142352008	byFrequency	TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr8:11400849C>T	uc003wty.2	+	2	697	c.116C>T	c.(115-117)CCG>CTG	p.P39L	BLK_uc003wtz.2_Intron	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	39					intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CCGCCACTGCCGCCCCTGGTG	0.393													T	11400849	T	T	11400849	3	4	181	1	0	0	0	0	1	0	0	0	1444	652	23	2	118	2	BLK	8	11400849	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08		11400849	134963173	48	12861											
GRHL2	79977	broad.mit.edu	37	chr8	102585963	102585963	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agcagggggagggccccatgAcctacctcaacaaaggacag	13	12	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr8:102585963A>T	uc010mbu.2	+	6	1132	c.802A>T	c.(802-804)ACC>TCC	p.T268S	GRHL2_uc011lhi.1_Missense_Mutation_p.T268S	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	268						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			GGGCCCCATGACCTACCTCAA	0.532													T	102585963	T	T	102585963	3	4	181	1	0	0	0	0	1	0	0	0	6764	275	10	5	824	5	GRHL2	8	102585963	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08	91185114	102585963	43778059	49	12862											
FER1L6	654463	broad.mit.edu	37	chr8	124992825	124992825	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaggtgtgtcattcagggGcagaatcttggtagaaattg	15	4	3	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr8:124992825G>A	uc003yqw.2	+	11	1390	c.1184G>A	c.(1183-1185)GGC>GAC	p.G395D		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	395	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCATTCAGGGGCAGAATCTTG	0.507											OREG0018964	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	124992825	A	A	124992825	3	1	181	1	0	0	0	0	1	0	0	0	5815	1203	42	3	1222	3	FER1L6	8	124992825	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	22406862	124992825	21371197	50	12863											
CHRAC1	54108	broad.mit.edu	37	chr8	141525277	141525277	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctgaaaatgcttaaagaGgaaaagagggaagaagatga	12	3	0	6			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr8:141525277G>A	uc003yvl.2	+	3	525	c.327G>A	c.(325-327)GAG>GAA	p.E109E	CHRAC1_uc010mem.1_RNA	NM_017444	NP_059140	Q9NRG0	CHRC1_HUMAN	chromatin accessibility complex 1	109	Potential.				chromatin remodeling	chromatin accessibility complex|epsilon DNA polymerase complex	DNA-directed DNA polymerase activity|sequence-specific DNA binding			ovary(1)	1	all_cancers(97;5.52e-16)|all_epithelial(106;1.22e-13)|Lung NSC(106;4.09e-06)|all_lung(105;6e-06)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.107)			TGCTTAAAGAGGAAAAGAGGG	0.353													A	141525277	A	A	141525277	2	1	181	1	0	0	0	0	0	0	0	1	3371	991	35	3		3	CHRAC1	8	141525277	Silent	SNP	G	TCGA-26-6174-01A-21D-1845-08	16532452	141525277	4838745	51	12864											
TOPORS	10210	broad.mit.edu	37	chr9	32543467	32543467	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaactgataaattcatgTataaaatgctcagttcgatt	6	6	2	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr9:32543467T>C	uc003zrb.2	-	3	1223	c.1056A>G	c.(1054-1056)ATA>ATG	p.I352M	TOPORS_uc003zrc.2_Missense_Mutation_p.I285M	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	352	Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TAAATTCATGTATAAAATGCT	0.398													C	32543467	C	C	32543467	3	2	181	1	0	0	0	0	1	0	0	0	16367	1628	57	4	2085	4	TOPORS	9	32543467	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08		32543467	108669964	52	12865											
ZMYND19	116225	broad.mit.edu	37	chr9	140477434	140477434	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accgcactgcagcacacccaCctgcttctcaatcactgtgc	6	18	2	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr9:140477434C>T	uc004cno.1	-	5	762	c.540_splice	c.e5+1	p.Q180_splice		NM_138462	NP_612471	Q96E35	ZMY19_HUMAN	zinc finger, MYND domain containing 19							Golgi apparatus|plasma membrane	zinc ion binding			skin(1)	1	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)		AGCACACCCACCTGCTTCTCA	0.587													T	140477434	T	T	140477434	5	4	181	1	0	0	0	0	0	0	1	0	17707	521	18	3	150	3	ZMYND19	9	140477434	Splice_Site	SNP	C	TCGA-26-6174-01A-21D-1845-08	107933967	140477434	735997	53	12866											
ITIH2	3698	broad.mit.edu	37	chr10	7759687	7759687	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctaccaggaggtgaagtggaGgaagctgggctcctatgagc	16	8	0	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr10:7759687G>T	uc001ijs.2	+	6	728	c.566G>T	c.(565-567)AGG>ATG	p.R189M		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	189					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						GTGAAGTGGAGGAAGCTGGGC	0.522													T	7759687	T	T	7759687	3	4	181	1	0	0	0	0	1	0	0	0	7904	1000	35	5	588	5	ITIH2	10	7759687	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		7759687	127775060	54	12867											
CTNNA3	29119	broad.mit.edu	37	chr10	68139038	68139038	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctgatagcacccgcagcaCggtctaaattatcagcatcc	7	14	3	1	rs139378888	by1000genomes	TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr10:68139038C>T	uc009xpn.1	-	12	1727	c.1604G>A	c.(1603-1605)CGT>CAT	p.R535H	CTNNA3_uc001jmw.2_Missense_Mutation_p.R535H	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	535					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						ACCCGCAGCACGGTCTAAATT	0.458													T	68139038	T	T	68139038	3	4	181	1	0	0	0	0	1	0	0	0	4014	536	19	1	1111	1	CTNNA3	10	68139038	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	60379351	68139038	67395709	55	12868											
PTEN	5728	broad.mit.edu	37	chr10	89711915	89711915	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaggcgctatgtgtattattAtagctacctgttaaagaatc	9	6	0	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr10:89711915A>G	uc001kfb.2	+	7	1564	c.533A>G	c.(532-534)TAT>TGT	p.Y178C		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	178	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.Y178*(1)|p.G165_K342del(1)|p.Y177fs*1(1)|p.G165_*404del(1)|p.V175fs*3(1)|p.Y178fs*5(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GTGTATTATTATAGCTACCTG	0.368		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			G	89711915	G	G	89711915	3	3	181	1	0	0	0	0	1	0	0	0	12738	449	16	4	555	4	PTEN	10	89711915	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08	21572877	89711915	45822832	56	12869											
IFIT2	3433	broad.mit.edu	37	chr10	91066921	91066921	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agagggtgtaaaaataaaccAgaaatcaagggagaaagaaa	11	3	1	4			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr10:91066921A>T	uc009xts.2	+	2	1383	c.1208A>T	c.(1207-1209)CAG>CTG	p.Q403L	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	403	TPR 6.				negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				AAAATAAACCAGAAATCAAGG	0.398													T	91066921	T	T	91066921	3	4	181	1	0	0	0	0	1	0	0	0	7523	188	7	5	1214	5	IFIT2	10	91066921	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08	1355006	91066921	44467826	57	12870											
SLC22A18	5002	broad.mit.edu	37	chr11	2939241	2939241	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcccccgggccagtgtgttcGacctgaaggccatcgcctcc	12	17	0	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr11:2939241G>A	uc001lwx.2	+	7	897	c.679G>A	c.(679-681)GAC>AAC	p.D227N	SLC22A18_uc001lwy.2_Missense_Mutation_p.D227N|SLC22A18_uc001lwz.2_Missense_Mutation_p.D129N	NM_183233	NP_899056	Q96BI1	S22AI_HUMAN	tumor suppressing subtransferable candidate 5	227				D -> E (in Ref. 4; AAB82727 and 6; AAC23505).	excretion|organic cation transport	apical plasma membrane|cytoplasmic part|integral to membrane|nuclear envelope	drug:hydrogen antiporter activity|symporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|ovary(1)	3		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.192)		CAGTGTGTTCGACCTGAAGGC	0.672													A	2939241	A	A	2939241	3	1	181	1	0	0	0	0	1	0	0	0	14449	1058	37	2	701	2	SLC22A18	11	2939241	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		2939241	132067275	58	12871											
OR4C13	283092	broad.mit.edu	37	chr11	49974296	49974296	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gagaacattttttcagaggtGttgaggtcatcctacttact	9	7	2	3			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr11:49974296G>T	uc010rhz.1	+	1	322	c.322G>T	c.(322-324)GTT>TTT	p.V108F		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						TTTCAGAGGTGTTGAGGTCAT	0.423													T	49974296	T	T	49974296	3	4	181	1	0	0	0	0	1	0	0	0	11047	1377	48	5	324	5	OR4C13	11	49974296	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	47035055	49974296	85032220	59	12872											
OR5L1	219437	broad.mit.edu	37	chr11	55579768	55579768	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgctgacaaagtggccaccGtgttctacacagtcgtgatt	10	10	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr11:55579768G>A	uc001nhw.1	+	1	826	c.826G>A	c.(826-828)GTG>ATG	p.V276M		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				AGTGGCCACCGTGTTCTACAC	0.458													A	55579768	A	A	55579768	3	1	181	1	0	0	0	0	1	0	0	0	11170	1145	40	1	828	1	OR5L1	11	55579768	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	5605472	55579768	79426748	60	12873											
OR5M9	390162	broad.mit.edu	37	chr11	56230082	56230082	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccattttgccctgctctaCggattcctcagtgggtctcc	8	15	3	0	rs148447943	byFrequency	TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr11:56230082C>T	uc010rjj.1	-	1	796	c.796G>A	c.(796-798)GTA>ATA	p.V266I		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CCCTGCTCTACGGATTCCTCA	0.468													T	56230082	T	T	56230082	3	4	181	1	0	0	0	0	1	0	0	0	11177	536	19	1	138	1	OR5M9	11	56230082	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	650314	56230082	78776434	61	12874											
CTTN	2017	broad.mit.edu	37	chr11	70266538	70266538	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtttggaggaaaatttggtGtgcagacagacagacaagac	14	5	0	4			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr11:70266538G>A	uc001opv.3	+	10	918	c.712G>A	c.(712-714)GTG>ATG	p.V238M	CTTN_uc001opu.2_Missense_Mutation_p.V238M|CTTN_uc001opw.3_Missense_Mutation_p.V238M|CTTN_uc010rqm.1_Translation_Start_Site|CTTN_uc001opx.2_5'Flank	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	238	Cortactin 5.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		AAAATTTGGTGTGCAGACAGA	0.458													A	70266538	A	A	70266538	3	1	181	1	0	0	0	0	1	0	0	0	4044	1377	48	3	742	3	CTTN	11	70266538	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	14036456	70266538	64739978	62	12875											
APLP2	334	broad.mit.edu	37	chr11	129992408	129992408	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaattactcatgatgtcaaaGgtaaccccatgtagagccat	7	9	2	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr11:129992408G>A	uc010sby.1	+	6	1079	c.922G>A	c.(922-924)GCT>ACT	p.A308T	APLP2_uc001qfp.2_Missense_Mutation_p.A308T|APLP2_uc001qfq.2_Missense_Mutation_p.V308I|APLP2_uc010sbz.1_Missense_Mutation_p.V152I|APLP2_uc001qfr.2_Missense_Mutation_p.V130I|APLP2_uc001qfs.2_Intron|APLP2_uc001qfv.2_Missense_Mutation_p.V255I	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	308	BPTI/Kunitz inhibitor.|Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TGATGTCAAAGGTAACCCCAT	0.443													A	129992408	A	A	129992408	3	1	181	1	0	0	0	0	1	0	0	0	779	1014	35	3	944	3	APLP2	11	129992408	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	59725870	129992408	5014108	63	12876											
KRT79	338785	broad.mit.edu	37	chr12	53217702	53217702	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcatcagcctccccctgcAgcctctggatagtgcgggtg	12	15	2	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr12:53217702A>G	uc001sbb.2	-	6	1148	c.1115T>C	c.(1114-1116)CTG>CCG	p.L372P	KRT79_uc001sba.2_Missense_Mutation_p.L143P	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	372	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						CTCCCCCTGCAGCCTCTGGAT	0.617													G	53217702	G	G	53217702	3	3	181	1	0	0	0	0	1	0	0	0	8492	188	7	4	508	4	KRT79	12	53217702	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08		53217702	80634193	64	12877											
PTPRB	5787	broad.mit.edu	37	chr12	70974843	70974843	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccctccacaaccacttgtcGggaagagatccctccactca	6	17	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr12:70974843G>A	uc001swb.3	-	8	1927	c.1897C>T	c.(1897-1899)CGA>TGA	p.R633*	PTPRB_uc010sto.1_Nonsense_Mutation_p.R633*|PTPRB_uc010stp.1_Nonsense_Mutation_p.R543*|PTPRB_uc001swc.3_Nonsense_Mutation_p.R851*|PTPRB_uc001swa.3_Nonsense_Mutation_p.R851*|PTPRB_uc001swd.3_Nonsense_Mutation_p.R850*|PTPRB_uc009zrr.1_Nonsense_Mutation_p.R730*	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	633	Fibronectin type-III 7.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACCACTTGTCGGGAAGAGATC	0.468													A	70974843	A	A	70974843	4	1	181	1	0	0	0	0	0	1	0	0	12796	1124	39	2	4196	2	PTPRB	12	70974843	Nonsense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	17757141	70974843	62877052	65	12878											
ANO4	121601	broad.mit.edu	37	chr12	101493475	101493475	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccgatgaatgcctatggacTcttcgatgaatacttagaaa	9	8	1	3			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr12:101493475T>C	uc010svm.1	+	22	2698	c.2126T>C	c.(2125-2127)CTC>CCC	p.L709P	ANO4_uc001thw.2_Missense_Mutation_p.L674P|ANO4_uc001thx.2_Missense_Mutation_p.L709P|ANO4_uc001thy.2_Missense_Mutation_p.L229P	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	709	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GCCTATGGACTCTTCGATGAA	0.333										HNSCC(74;0.22)			C	101493475	C	C	101493475	3	2	181	1	0	0	0	0	1	0	0	0	699	1551	54	4	2099	4	ANO4	12	101493475	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08	30518632	101493475	32358420	66	12879											
RNF17	56163	broad.mit.edu	37	chr13	25373533	25373533	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtttccctcattatttagGtgcaagaatatttgtcagca	7	7	2	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr13:25373533G>A	uc001upr.2	+	12	1441	c.1400G>A	c.(1399-1401)GGT>GAT	p.G467D	RNF17_uc010tdd.1_Missense_Mutation_p.G326D|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.G467D|RNF17_uc001ups.2_Missense_Mutation_p.G406D	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	467					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CATTATTTAGGTGCAAGAATA	0.328													A	25373533	A	A	25373533	3	1	181	1	0	0	0	0	1	0	0	0	13461	1275	44	3	1446	3	RNF17	13	25373533	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		25373533	89796345	67	12880											
BRCA2	675	broad.mit.edu	37	chr13	32913746	32913746	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgtctaacagctattcctacCattctgatgaggtatataat	6	8	2	2	rs80358749		TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr13:32913746C>A	uc001uub.1	+	11	5481	c.5254C>A	c.(5254-5256)CAT>AAT	p.H1752N		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1752					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CTATTCCTACCATTCTGATGA	0.308			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			A	32913746	A	A	32913746	3	1	181	1	0	0	0	0	1	0	0	0	1499	594	21	5	5292	5	BRCA2	13	32913746	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	7540213	32913746	82256132	68	12881											
TNFSF11	8600	broad.mit.edu	37	chr13	43175077	43175077	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agcaagcttgaagctcagccTtttgctcatctcactattaa	6	11	3	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr13:43175077T>A	uc001uyu.2	+	4	641	c.492T>A	c.(490-492)CCT>CCA	p.P164P	TNFSF11_uc001uyt.2_Silent_p.P91P	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	164	Extracellular (Potential).				immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		AAGCTCAGCCTTTTGCTCATC	0.428													A	43175077	A	A	43175077	2	1	181	1	0	0	0	0	0	0	0	1	16299	1596	56	5		5	TNFSF11	13	43175077	Silent	SNP	T	TCGA-26-6174-01A-21D-1845-08	10261331	43175077	71994801	69	12882											
OR4M1	441670	broad.mit.edu	37	chr14	20249338	20249338	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatattccctttacttaatcCcattatttacacattgagaa	2	9	0	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr14:20249338C>T	uc010tku.1	+	1	857	c.857C>T	c.(856-858)CCC>CTC	p.P286L		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTACTTAATCCCATTATTTAC	0.363													T	20249338	T	T	20249338	3	4	181	1	0	0	0	0	1	0	0	0	11075	623	22	3	859	3	OR4M1	14	20249338	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08		20249338	87100202	70	12883											
CHD8	57680	broad.mit.edu	37	chr14	21897227	21897227	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agaggacagagtcactggctGggtggagggtggctgctggg	21	6	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr14:21897227G>C	uc001was.1	-	3	368	c.274C>G	c.(274-276)CAG>GAG	p.Q92E	CHD8_uc001war.1_5'UTR	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	371	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GTCACTGGCTGGGTGGAGGGT	0.547													C	21897227	C	C	21897227	3	2	181	1	0	0	0	0	1	0	0	0	3331	1357	47	5	6778	5	CHD8	14	21897227	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	1647889	21897227	85452313	71	12884											
SLC35F4	341880	broad.mit.edu	37	chr14	58063582	58063582	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cagctgcctcccactggtcaGtttgtggaagagatccaaga	11	11	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr14:58063582G>C	uc001xdb.1	-	1	34	c.34C>G	c.(34-36)CTG>GTG	p.L12V	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_5'UTR	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						CCACTGGTCAGTTTGTGGAAG	0.428													C	58063582	C	C	58063582	3	2	181	1	0	0	0	0	1	0	0	0	14591	1020	36	5	1563	5	SLC35F4	14	58063582	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	36166355	58063582	49285958	72	12885											
ATG2B	55102	broad.mit.edu	37	chr14	96779478	96779478	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacggtaagaagagatcggaTtggcaaataaaggggtctaa	13	5	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr14:96779478T>C	uc001yfi.2	-	25	4131	c.3766A>G	c.(3766-3768)ATC>GTC	p.I1256V		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1256										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AGAGATCGGATTGGCAAATAA	0.348													C	96779478	C	C	96779478	3	2	181	1	0	0	0	0	1	0	0	0	1094	1493	52	4	2542	4	ATG2B	14	96779478	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08	38715896	96779478	10570062	73	12886											
FAM81A	145773	broad.mit.edu	37	chr15	59752269	59752269	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcgtagagcacgcctttcGgattaaagatgacattgtca	9	10	1	3			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr15:59752269G>A	uc002agc.2	+	3	345	c.158G>A	c.(157-159)CGG>CAG	p.R53Q	FAM81A_uc010uha.1_Missense_Mutation_p.R53Q	NM_152450	NP_689663	Q8TBF8	FA81A_HUMAN	hypothetical protein LOC145773	53										ovary(1)	1						CACGCCTTTCGGATTAAAGAT	0.502													A	59752269	A	A	59752269	3	1	181	1	0	0	0	0	1	0	0	0	5628	1116	39	2	164	2	FAM81A	15	59752269	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		59752269	42779123	74	12887											
MAN2A2	4122	broad.mit.edu	37	chr15	91452684	91452684	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggatgcccagttcttcaacTaccaacggctctttgacttc	8	13	3	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr15:91452684T>C	uc010bnz.2	+	9	1439	c.1324T>C	c.(1324-1326)TAC>CAC	p.Y442H	MAN2A2_uc010boa.2_Missense_Mutation_p.Y484H|MAN2A2_uc002bqc.2_Missense_Mutation_p.Y442H|MAN2A2_uc010uql.1_Missense_Mutation_p.Y146H|MAN2A2_uc010uqm.1_Silent_p.T88T|MAN2A2_uc010uqn.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	442	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GTTCTTCAACTACCAACGGCT	0.567													C	91452684	C	C	91452684	3	2	181	1	0	0	0	0	1	0	0	0	9215	1522	53	4	1354	4	MAN2A2	15	91452684	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08	31700415	91452684	11078708	75	12888											
SPATA8	145946	broad.mit.edu	37	chr15	97326893	97326893	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagggcatgaggaatggcccCggctgggatgtcaggggccc	18	10	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr15:97326893C>T	uc002bue.2	+	1	218	c.8C>T	c.(7-9)CCG>CTG	p.P3L	uc010uro.1_5'Flank|uc010urp.1_5'Flank|uc002bud.1_5'Flank	NM_173499	NP_775770	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	3										ovary(1)|skin(1)	2	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			GGAATGGCCCCGGCTGGGATG	0.567													T	97326893	T	T	97326893	3	4	181	1	0	0	0	0	1	0	0	0	15014	652	23	2	10	2	SPATA8	15	97326893	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	5874209	97326893	5204499	76	12889											
PDILT	204474	broad.mit.edu	37	chr16	20373885	20373885	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agtgggaacagcatcttgcaCtttttagaccagggtgcatc	11	9	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr16:20373885C>G	uc002dhc.1	-	10	1480	c.1257G>C	c.(1255-1257)AAG>AAC	p.K419N		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	419	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						GCATCTTGCACTTTTTAGACC	0.473													G	20373885	G	G	20373885	3	3	181	1	0	0	0	0	1	0	0	0	11674	564	20	5	509	5	PDILT	16	20373885	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08		20373885	69980868	77	12890											
ERN2	10595	broad.mit.edu	37	chr16	23712369	23712369	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggtcccagccccaagtaagAgtctggagttttttcttctg	11	10	3	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr16:23712369A>G	uc002dma.3	-	12	1583	c.1414T>C	c.(1414-1416)TCT>CCT	p.S472P	ERN2_uc010bxp.2_Intron|ERN2_uc010bxq.1_Missense_Mutation_p.S280P	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	424	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CCCAAGTAAGAGTCTGGAGTT	0.562													G	23712369	G	G	23712369	3	3	181	1	0	0	0	0	1	0	0	0	5238	304	11	4	1554	4	ERN2	16	23712369	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08	3338484	23712369	66642384	78	12891											
PRKCB	5579	broad.mit.edu	37	chr16	24202548	24202548	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagcccccttataagccaaaAgctgtaagtagcccattctc	6	14	1	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr16:24202548A>G	uc002dmd.2	+	16	2057	c.1860A>G	c.(1858-1860)AAA>AAG	p.K620K	PRKCB_uc002dme.2_Silent_p.K620K	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	620	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	ATAAGCCAAAAGCTGTAAGTA	0.473													G	24202548	G	G	24202548	2	3	181	1	0	0	0	0	0	0	0	1	12508	69	3	4		4	PRKCB	16	24202548	Silent	SNP	A	TCGA-26-6174-01A-21D-1845-08	490179	24202548	66152205	79	12892											
LPCAT2	54947	broad.mit.edu	37	chr16	55543215	55543215	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcttcccgccgccggtgcCgaaccccttcgtgcagcaga	10	18	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr16:55543215C>T	uc002eie.3	+	1	303	c.122C>T	c.(121-123)CCG>CTG	p.P41L		NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	41	Cytoplasmic (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0						CCGCCGGTGCCGAACCCCTTC	0.726													T	55543215	T	T	55543215	3	4	181	1	0	0	0	0	1	0	0	0	8911	652	23	2	124	2	LPCAT2	16	55543215	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	31340667	55543215	34811538	80	12893											
C16orf46	123775	broad.mit.edu	37	chr16	81095126	81095126	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaggggaggatggcgtgtcGttgaccatagggtgtttggc	19	5	0	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr16:81095126G>A	uc002fgc.3	-	4	1087	c.828C>T	c.(826-828)AAC>AAT	p.N276N	C16orf46_uc010chf.2_Silent_p.N276N|C16orf46_uc010vno.1_Silent_p.N3N	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	276											0						ATGGCGTGTCGTTGACCATAG	0.552													A	81095126	A	A	81095126	2	1	181	1	0	0	0	0	0	0	0	1	1815	1136	40	1		1	C16orf46	16	81095126	Silent	SNP	G	TCGA-26-6174-01A-21D-1845-08	25551911	81095126	9259627	81	12894											
KIAA0513	9764	broad.mit.edu	37	chr16	85120720	85120720	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctttggactgaacaagaaGctgtgcaatgacttcctgaa	10	9	0	4			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr16:85120720G>A	uc002fiu.2	+	12	1354	c.1134G>A	c.(1132-1134)AAG>AAA	p.K378K	KIAA0513_uc010voj.1_Silent_p.K368K	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	378						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		TGAACAAGAAGCTGTGCAATG	0.612											OREG0023994	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	85120720	A	A	85120720	2	1	181	1	0	0	0	0	0	0	0	1	8181	962	34	3		3	KIAA0513	16	85120720	Silent	SNP	G	TCGA-26-6174-01A-21D-1845-08	4025594	85120720	5234033	82	12895											
SENP3	26168	broad.mit.edu	37	chr17	7466491	7466491	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccaggcgggagcgtcttcGttggcccccacctcccaaac	10	18	1	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr17:7466491G>A	uc002ghm.2	+	2	371	c.98G>A	c.(97-99)CGT>CAT	p.R33H	EIF4A1_uc002gho.1_5'Flank|SENP3_uc002ghn.1_5'Flank	NM_015670	NP_056485	Q9H4L4	SENP3_HUMAN	SUMO1/sentrin/SMT3 specific protease 3	33	Pro-rich.				proteolysis	MLL1 complex|nucleolus	cysteine-type peptidase activity			ovary(1)|central_nervous_system(1)	2		Prostate(122;0.157)				GAGCGTCTTCGTTGGCCCCCA	0.637													A	7466491	A	A	7466491	3	1	181	1	0	0	0	0	1	0	0	0	14048	1145	40	1	100	1	SENP3	17	7466491	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		7466491	73728719	83	12896											
ALOX15B	247	broad.mit.edu	37	chr17	7948185	7948185	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcaggaggacgccttcttcGcctcccagttcctgaatggt	12	13	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr17:7948185G>A	uc002gju.2	+	6	831	c.715G>A	c.(715-717)GCC>ACC	p.A239T	ALOX15B_uc002gjv.2_Missense_Mutation_p.A239T|ALOX15B_uc002gjw.2_Missense_Mutation_p.A239T|ALOX15B_uc010vun.1_Missense_Mutation_p.A239T|ALOX15B_uc010cnp.2_Missense_Mutation_p.A45T	NM_001141	NP_001132	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, second type	239	Lipoxygenase.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1						CGCCTTCTTCGCCTCCCAGTT	0.607													A	7948185	A	A	7948185	3	1	181	1	0	0	0	0	1	0	0	0	539	1087	38	1	737	1	ALOX15B	17	7948185	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	481694	7948185	73247025	84	12897											
KRT24	192666	broad.mit.edu	37	chr17	38859417	38859417	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agacccaggcccatatttgtCataccactccttgattttgt	6	12	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr17:38859417C>T	uc002hvd.2	-	1	586	c.529G>A	c.(529-531)GAC>AAC	p.D177N		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	177	Linker 1.|Rod.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CCATATTTGTCATACCACTCC	0.458													T	38859417	T	T	38859417	3	4	181	1	0	0	0	0	1	0	0	0	8461	826	29	3	1080	3	KRT24	17	38859417	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	30911232	38859417	42335793	85	12898											
ABCA6	23460	broad.mit.edu	37	chr17	67079124	67079124	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atgtaatccttgccaagtttGtttttcaggtgttggatgga	11	5	1	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr17:67079124G>C	uc002jhw.1	-	36	4681	c.4506C>G	c.(4504-4506)AAC>AAG	p.N1502K		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1502	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					TGCCAAGTTTGTTTTTCAGGT	0.378													C	67079124	C	C	67079124	3	2	181	1	0	0	0	0	1	0	0	0	36	1368	48	5	363	5	ABCA6	17	67079124	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	28219707	67079124	14116086	86	12899											
ZNF236	7776	broad.mit.edu	37	chr18	74625839	74625839	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctggggtcctcaagtcccacGagaagacacacacaggtcac	10	14	2	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr18:74625839G>A	uc002lmi.2	+	18	3238	c.3040G>A	c.(3040-3042)GAG>AAG	p.E1014K	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1014	C2H2-type 19.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CAAGTCCCACGAGAAGACACA	0.413													A	74625839	A	A	74625839	3	1	181	1	0	0	0	0	1	0	0	0	17786	1059	37	2	3110	2	ZNF236	18	74625839	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		74625839	3451409	87	12900											
PTPRS	5802	broad.mit.edu	37	chr19	5221104	5221104	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgctgggcttgccgttgagcAggttgaaggcagtccaggcg	17	10	0	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr19:5221104A>C	uc002mbv.2	-	20	3596	c.3362T>G	c.(3361-3363)CTG>CGG	p.L1121R	PTPRS_uc002mbu.1_Missense_Mutation_p.L690R|PTPRS_uc010xin.1_Missense_Mutation_p.L690R|PTPRS_uc002mbw.2_Missense_Mutation_p.L1099R|PTPRS_uc002mbx.2_Missense_Mutation_p.L694R|PTPRS_uc002mby.2_Missense_Mutation_p.L690R	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1121	Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GCCGTTGAGCAGGTTGAAGGC	0.622													C	5221104	C	C	5221104	3	2	181	1	0	0	0	0	1	0	0	0	12811	188	7	5	2560	5	PTPRS	19	5221104	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08		5221104	53907879	88	12901											
KIAA1543	57662	broad.mit.edu	37	chr19	7676675	7676675	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctccgctctgtgagctcGgacagcctgggccccccgcg	12	19	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr19:7676675G>A	uc002mgv.3	+	11	1397	c.1296G>A	c.(1294-1296)TCG>TCA	p.S432S	KIAA1543_uc002mgu.3_Silent_p.S459S|KIAA1543_uc002mgw.2_5'Flank	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	432					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						CTGTGAGCTCGGACAGCCTGG	0.687													A	7676675	A	A	7676675	2	1	181	1	0	0	0	0	0	0	0	1	8243	1103	39	2		2	KIAA1543	19	7676675	Silent	SNP	G	TCGA-26-6174-01A-21D-1845-08	2455571	7676675	51452308	89	12902											
ZNF99	7652	broad.mit.edu	37	chr19	22940690	22940690	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcacatttgtagggtttcTcttcagtatgaattacttta	6	7	3	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr19:22940690T>C	uc010xrh.1	-	5	1748	c.1748A>G	c.(1747-1749)GAG>GGG	p.E583G		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GTAGGGTTTCTCTTCAGTATG	0.358													C	22940690	C	C	22940690	3	2	181	1	0	0	0	0	1	0	0	0	18201	1551	54	4	1376	4	ZNF99	19	22940690	Missense_Mutation	SNP	T	TCGA-26-6174-01A-21D-1845-08	15264015	22940690	36188293	90	12903											
SFRS16	11129	broad.mit.edu	37	chr19	45561033	45561033	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagaagaaggcttccatcGgttatacctacgaggacagc	11	10	0	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr19:45561033G>A	uc002pak.2	+	7	588	c.490G>A	c.(490-492)GGT>AGT	p.G164S	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.G102S|SFRS16_uc002pam.2_Missense_Mutation_p.G164S|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	164					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGCTTCCATCGGTTATACCTA	0.592													A	45561033	A	A	45561033	3	1	181	1	0	0	0	0	1	0	0	0	14172	1116	39	2	512	2	SFRS16	19	45561033	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	22620343	45561033	13567950	91	12904											
ZNF347	84671	broad.mit.edu	37	chr19	53645135	53645135	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acactcattacatttgtaacGtttttcgccagtatggatca	6	9	2	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr19:53645135G>A	uc002qbb.1	-	5	1015	c.946C>T	c.(946-948)CGT>TGT	p.R316C	ZNF347_uc010eql.1_Missense_Mutation_p.R317C|ZNF347_uc002qbc.1_Missense_Mutation_p.R317C	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		CATTTGTAACGTTTTTCGCCA	0.373													A	53645135	A	A	53645135	3	1	181	1	0	0	0	0	1	0	0	0	17858	1145	40	1	1577	1	ZNF347	19	53645135	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	8084102	53645135	5483848	92	12905											
LILRA4	23547	broad.mit.edu	37	chr19	54850352	54850352	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aaagaagagcaggcttgtgaGaatgagggtcatggcatctc	14	6	2	4			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr19:54850352G>C	uc002qfj.2	-	1	70	c.13C>G	c.(13-15)CTC>GTC	p.L5V	LILRA4_uc002qfi.2_5'UTR	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	5						integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		AGGCTTGTGAGAATGAGGGTC	0.567													C	54850352	C	C	54850352	3	2	181	1	0	0	0	0	1	0	0	0	8787	942	33	5	1518	5	LILRA4	19	54850352	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	1205217	54850352	4278631	93	12906											
REM1	28954	broad.mit.edu	37	chr20	30065686	30065686	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaagacaccacactggtggtCgtggacacctgggaggccga	15	11	0	1	rs147559982		TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chr20:30065686C>T	uc002wwa.2	+	3	680	c.396C>T	c.(394-396)GTC>GTT	p.V132V		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	132					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CACTGGTGGTCGTGGACACCT	0.572													T	30065686	T	T	30065686	2	4	181	1	0	0	0	0	0	0	0	1	13222	871	31	2		2	REM1	20	30065686	Silent	SNP	C	TCGA-26-6174-01A-21D-1845-08		30065686	32959834	94	12907											
PORCN	64840	broad.mit.edu	37	chrX	48371104	48371104	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacggtgaccgcctccttcGcaagtgagcacagccttcga	10	15	0	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chrX:48371104G>A	uc010nie.1	+	6	841	c.683G>A	c.(682-684)CGC>CAC	p.R228H	PORCN_uc004djr.1_Missense_Mutation_p.R228H|PORCN_uc004djs.1_Missense_Mutation_p.R228H|PORCN_uc004djt.1_Missense_Mutation_p.R157H|PORCN_uc011mlx.1_Missense_Mutation_p.R157H|PORCN_uc004dju.1_Missense_Mutation_p.R97H|PORCN_uc004djv.1_Missense_Mutation_p.R228H|PORCN_uc004djw.1_Missense_Mutation_p.R228H	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	228	Extracellular (Potential).		R -> C (in a patient with focal dermal hypoplasia also carrying a frameshift mutation; uncertain pathological significance).		Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						CGCCTCCTTCGCAAGTGAGCA	0.622													A	48371104	A	A	48371104	3	1	181	1	0	0	0	0	1	0	0	0	12258	1087	38	1	701	1	PORCN	23	48371104	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08		48371104	106899456	95	12908											
PQBP1	10084	broad.mit.edu	37	chrX	48759746	48759746	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggaagagggcaaagaacggCgccaccatcgccgggaggag	18	10	0	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chrX:48759746C>T	uc004dle.2	+	5	718	c.529C>T	c.(529-531)CGC>TGC	p.R177C	PQBP1_uc004dlf.2_Missense_Mutation_p.R177C|PQBP1_uc004dlg.2_Missense_Mutation_p.R177C|PQBP1_uc004dld.2_Intron|PQBP1_uc004dlh.2_Missense_Mutation_p.R177C|PQBP1_uc004dli.2_Missense_Mutation_p.R177C|PQBP1_uc004dlj.1_Missense_Mutation_p.R177C|PQBP1_uc004dln.2_Missense_Mutation_p.R177C|PQBP1_uc010nih.2_RNA|PQBP1_uc010nii.2_Missense_Mutation_p.R135C|PQBP1_uc004dlk.2_Intron|PQBP1_uc004dll.2_Intron|PQBP1_uc004dlm.2_Missense_Mutation_p.R135C|PQBP1_uc010nij.2_Missense_Mutation_p.R77C	NM_001032382	NP_001027554	O60828	PQBP1_HUMAN	polyglutamine binding protein 1	177	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|transcription coactivator activity			large_intestine(1)	1						CAAAGAACGGCGCCACCATCG	0.612													T	48759746	T	T	48759746	3	4	181	1	0	0	0	0	1	0	0	0	12417	768	27	1	543	1	PQBP1	23	48759746	Missense_Mutation	SNP	C	TCGA-26-6174-01A-21D-1845-08	388642	48759746	106510814	96	12909											
CHM	1121	broad.mit.edu	37	chrX	85156121	85156121	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgtgagcacatgttctcaggAaagtaactgtcctccacgag	10	11	1	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chrX:85156121A>T	uc004eet.2	-	10	1347	c.1317T>A	c.(1315-1317)TTT>TTA	p.F439L	CHM_uc011mqz.1_Missense_Mutation_p.F291L	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	439					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				TGTTCTCAGGAAAGTAACTGT	0.393													T	85156121	T	T	85156121	3	4	181	1	0	0	0	0	1	0	0	0	3350	243	9	5	668	5	CHM	23	85156121	Missense_Mutation	SNP	A	TCGA-26-6174-01A-21D-1845-08	36396375	85156121	70114439	97	12910											
CXorf61	203413	broad.mit.edu	37	chrX	115592953	115592953	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcacctctgaaacccttgctAagtagagtatgttccagttc	8	11	1	2			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chrX:115592953A>C	uc004eqj.1	-	2	417	c.297T>G	c.(295-297)CTT>CTG	p.L99L		NM_001017978	NP_001017978	Q5H943	KKLC1_HUMAN	chromosome X open reading frame 61	99	Extracellular (Potential).					integral to membrane|plasma membrane					0						AACCCTTGCTAAGTAGAGTAT	0.418													C	115592953	C	C	115592953	2	2	181	1	0	0	0	0	0	0	0	1	4116	349	13	5		5	CXorf61	23	115592953	Silent	SNP	A	TCGA-26-6174-01A-21D-1845-08	30436832	115592953	39677607	98	12911											
ARHGEF6	9459	broad.mit.edu	37	chrX	135825762	135825762	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accactggatttaatttcacGgacataattactggggaacc	8	9	1	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chrX:135825762G>A	uc004fab.2	-	5	1105	c.643C>T	c.(643-645)CGT>TGT	p.R215C	ARHGEF6_uc011mwd.1_Missense_Mutation_p.R61C|ARHGEF6_uc011mwe.1_Missense_Mutation_p.R61C	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	215	SH3.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					TTAATTTCACGGACATAATTA	0.388													A	135825762	A	A	135825762	3	1	181	1	0	0	0	0	1	0	0	0	910	1116	39	2	1759	2	ARHGEF6	23	135825762	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	20232809	135825762	19444798	99	12912											
MCF2	4168	broad.mit.edu	37	chrX	138668562	138668562	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgcttctgcctgaactgaCgcaattgcctcacagacctc	7	14	2	3	rs142128026	byFrequency	TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chrX:138668562C>T	uc004fau.2	-	23	2901	c.2607G>A	c.(2605-2607)GCG>GCA	p.A869A	MCF2_uc004fav.2_Silent_p.A885A|MCF2_uc011mwl.1_Silent_p.A846A|MCF2_uc010nsh.1_Intron|MCF2_uc011mwm.1_Intron|MCF2_uc011mwn.1_Intron|MCF2_uc004faw.2_Silent_p.A929A|MCF2_uc011mwo.1_Silent_p.A945A	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	869					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					CCTGAACTGACGCAATTGCCT	0.413													T	138668562	T	T	138668562	2	4	181	1	0	0	0	0	0	0	0	1	9378	523	19	1		1	MCF2	23	138668562	Silent	SNP	C	TCGA-26-6174-01A-21D-1845-08	2842800	138668562	16601998	100	12913											
IDS	3423	broad.mit.edu	37	chrX	148564457	148564457	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctatagtctatggtgcgtatGgaatagcccatgatctttat	9	7	2	1			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chrX:148564457G>T	uc011mxe.1	-	9	1671	c.1473C>A	c.(1471-1473)TCC>TCA	p.S491S	IDS_uc011mxd.1_Silent_p.S94S|IDS_uc011mxf.1_Silent_p.S401S|IDS_uc011mxg.1_Silent_p.S280S|IDS_uc010nsu.1_Silent_p.S101S|IDS_uc004fcw.3_Silent_p.S280S	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	491			S -> F (in MPS2; mild form).			lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					TGGTGCGTATGGAATAGCCCA	0.433													T	148564457	T	T	148564457	2	4	181	1	0	0	0	0	0	0	0	1	7503	1335	47	5		5	IDS	23	148564457	Silent	SNP	G	TCGA-26-6174-01A-21D-1845-08	9895895	148564457	6706103	101	12914											
DKC1	1736	broad.mit.edu	37	chrX	154001511	154001511	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cacttaccctcggaagtgggGtttaggtccaaaggtaagtg	13	8	0	0			TCGA-26-6174-01A-21D-1845-08	TCGA-26-6174-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	3ba04f15-48f4-4851-a21f-8fa7cc9eac6b	59389092-6f21-4cb4-b44e-b0ac30d38963	g.chrX:154001511G>C	uc004fmm.2	+	11	1352	c.1142G>C	c.(1141-1143)GGT>GCT	p.G381A	DKC1_uc010nvf.2_Missense_Mutation_p.G381A|SNORA56_uc004fmo.2_5'Flank	NM_001363	NP_001354	O60832	DKC1_HUMAN	dyskerin isoform 1	381					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGGAAGTGGGGTTTAGGTCCA	0.383									Congenital_Dyskeratosis				C	154001511	C	C	154001511	3	2	181	1	0	0	0	0	1	0	0	0	4542	1261	44	5	1184	5	DKC1	23	154001511	Missense_Mutation	SNP	G	TCGA-26-6174-01A-21D-1845-08	5437054	154001511	1269049	102	12915											
COL16A1	1307	broad.mit.edu	37	chr1	32163660	32163660	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acactcagcatcagcttgtgCcaacgcaagtcgaagagctg	10	12	2	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr1:32163660C>T	uc001btk.1	-	6	869	c.504G>A	c.(502-504)TGG>TGA	p.W168*	COL16A1_uc001btj.1_5'UTR|COL16A1_uc001btl.3_Nonsense_Mutation_p.W168*	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	168	TSP N-terminal.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TCAGCTTGTGCCAACGCAAGT	0.642													T	32163660	T	T	32163660	4	4	182	1	0	0	0	0	0	1	0	0	3673	740	26	3	4574	3	COL16A1	1	32163660	Nonsense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08		32163660	217086961	1	12916											
FGGY	55277	broad.mit.edu	37	chr1	59805657	59805657	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacaagggattgatttaaacCaaattcgaggacttgggttt	10	5	0	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr1:59805657C>T	uc001czi.3	+	3	441	c.229C>T	c.(229-231)CAA>TAA	p.Q77*	FGGY_uc001czg.2_Intron|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Nonsense_Mutation_p.Q77*|FGGY_uc001czj.3_Nonsense_Mutation_p.Q77*|FGGY_uc001czk.3_5'UTR|FGGY_uc001czl.3_Intron	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	77					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					TGATTTAAACCAAATTCGAGG	0.363													T	59805657	T	T	59805657	4	4	182	1	0	0	0	0	0	1	0	0	5871	595	21	3	235	3	FGGY	1	59805657	Nonsense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	27641997	59805657	189444964	2	12917											
MSH4	4438	broad.mit.edu	37	chr1	76349367	76349367	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggcatcctattcttgaaaaAatatctgcggaaaaacctat	6	8	2	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr1:76349367A>T	uc001dhd.1	+	15	2009	c.1968A>T	c.(1966-1968)AAA>AAT	p.K656N		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	656					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TTCTTGAAAAAATATCTGCGG	0.313								MMR					T	76349367	T	T	76349367	3	4	182	1	0	0	0	0	1	0	0	0	9872	11	1	5	2026	5	MSH4	1	76349367	Missense_Mutation	SNP	A	TCGA-27-1830-01A-01W-0643-08	16543710	76349367	172901254	3	12918											
SYCP1	6847	broad.mit.edu	37	chr1	115487554	115487554	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acagaaagaaattgataagcGatgtcaacataaaatagctg	8	5	1	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr1:115487554G>A	uc001efr.2	+	25	2314	c.2105G>A	c.(2104-2106)CGA>CAA	p.R702Q	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Missense_Mutation_p.R702Q|SYCP1_uc009wgw.2_Missense_Mutation_p.R702Q	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	702	Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATTGATAAGCGATGTCAACAT	0.254													A	115487554	A	A	115487554	3	1	182	1	0	0	0	0	1	0	0	0	15428	1058	37	2	2199	2	SYCP1	1	115487554	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	39138187	115487554	133763067	4	12919											
PTGFRN	5738	broad.mit.edu	37	chr1	117484643	117484643	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaccaaggccactacaaatGttcaacccccagcacagatg	7	14	1	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr1:117484643G>T	uc001egv.1	+	2	493	c.356G>T	c.(355-357)TGT>TTT	p.C119F		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	119	Extracellular (Potential).|Ig-like C2-type 1.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		CACTACAAATGTTCAACCCCC	0.483													T	117484643	T	T	117484643	3	4	182	1	0	0	0	0	1	0	0	0	12750	1377	48	5	362	5	PTGFRN	1	117484643	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	1997089	117484643	131765978	5	12920											
CR2	1380	broad.mit.edu	37	chr1	207649599	207649599	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccttcatagggtgtccacctCcgcctaagacccctaacggg	9	16	1	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr1:207649599C>T	uc001hfw.2	+	14	2654	c.2560C>T	c.(2560-2562)CCG>TCG	p.P854S	CR2_uc001hfv.2_Missense_Mutation_p.P913S|CR2_uc009xch.2_Intron	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	854	Sushi 14.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						GTGTCCACCTCCGCCTAAGAC	0.493													T	207649599	T	T	207649599	3	4	182	1	0	0	0	0	1	0	0	0	3842	855	30	3	2795	3	CR2	1	207649599	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	90164956	207649599	41601022	6	12921											
SOS1	6654	broad.mit.edu	37	chr2	39262448	39262448	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttctttgaaaccttcgcctaTtgactggaaaaaaaagtgat	7	7	1	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr2:39262448T>C	uc002rrk.3	-	8	1020	c.979A>G	c.(979-981)ATA>GTA	p.I327V	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_5'UTR|SOS1_uc002rrl.2_Missense_Mutation_p.I59V	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	327	DH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				CCTTCGCCTATTGACTGGAAA	0.338									Noonan_syndrome				C	39262448	C	C	39262448	3	2	182	1	0	0	0	0	1	0	0	0	14936	1493	52	4	3086	4	SOS1	2	39262448	Missense_Mutation	SNP	T	TCGA-27-1830-01A-01W-0643-08		39262448	203936925	7	12922											
SLC4A5	57835	broad.mit.edu	37	chr2	74462257	74462257	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	actgggcacatgcagcttggGagtttctaggccaaaacagg	13	9	1	0			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr2:74462257G>C	uc002sko.1	-	17	2406	c.2404C>G	c.(2404-2406)CCC>GCC	p.P802A	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.P802A|SLC4A5_uc010ffc.1_Missense_Mutation_p.P802A|SLC4A5_uc002skp.1_Intron|SLC4A5_uc002sks.1_Intron	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	802	Cytoplasmic (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						TGCAGCTTGGGAGTTTCTAGG	0.547													C	74462257	C	C	74462257	3	2	182	1	0	0	0	0	1	0	0	0	14657	1174	41	5	1049	5	SLC4A5	2	74462257	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	35199809	74462257	168737116	8	12923											
LRP2	4036	broad.mit.edu	37	chr2	170092415	170092415	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	acaaaagtccatgtaatcaaGataggagtccatgaagtaga	9	6	1	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr2:170092415G>A	uc002ues.2	-	29	5068	c.4855C>T	c.(4855-4857)CTT>TTT	p.L1619F		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1619	LDL-receptor class B 13.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATGTAATCAAGATAGGAGTCC	0.453													A	170092415	A	A	170092415	3	1	182	1	0	0	0	0	1	0	0	0	8956	942	33	3	9316	3	LRP2	2	170092415	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	95630158	170092415	73106958	9	12924											
TTN	7273	broad.mit.edu	37	chr2	179410964	179410964	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actttgaccatgacagacacGgccttggtcccgctggcatt	10	13	0	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr2:179410964G>A	uc010zfg.1	-	291	87614	c.87390C>T	c.(87388-87390)GCC>GCT	p.A29130A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A22825A|TTN_uc010zfi.1_Silent_p.A22758A|TTN_uc010zfj.1_Silent_p.A22633A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30057							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGACAGACACGGCCTTGGTCC	0.428													A	179410964	A	A	179410964	2	1	182	1	0	0	0	0	0	0	0	1	16732	1103	39	2		2	TTN	2	179410964	Silent	SNP	G	TCGA-27-1830-01A-01W-0643-08	9318549	179410964	63788409	10	12925											
TTN	7273	broad.mit.edu	37	chr2	179462736	179462736	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atttgtagaatgctccttccTttaatcctgtcacaacaagc	5	11	1	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr2:179462736T>A	uc010zfg.1	-	242	49681	c.49457A>T	c.(49456-49458)AAG>ATG	p.K16486M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K10181M|TTN_uc010zfi.1_Missense_Mutation_p.K10114M|TTN_uc010zfj.1_Missense_Mutation_p.K9989M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17413							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTCCTTCCTTTAATCCTGT	0.383													A	179462736	A	A	179462736	3	1	182	1	0	0	0	0	1	0	0	0	16732	1609	56	5	50812	5	TTN	2	179462736	Missense_Mutation	SNP	T	TCGA-27-1830-01A-01W-0643-08	51772	179462736	63736637	11	12926											
MAP2	4133	broad.mit.edu	37	chr2	210518141	210518141	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acggagagctgacctcagctGacagagaaacagcaggtaac	12	10	1	4			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr2:210518141G>C	uc002vde.1	+	4	495	c.247G>C	c.(247-249)GAC>CAC	p.D83H	MAP2_uc002vdc.1_Missense_Mutation_p.D83H|MAP2_uc002vdd.1_Missense_Mutation_p.D83H|MAP2_uc002vdf.1_Missense_Mutation_p.D83H|MAP2_uc002vdg.1_Missense_Mutation_p.D83H|MAP2_uc002vdh.1_Missense_Mutation_p.D83H|MAP2_uc002vdi.1_Missense_Mutation_p.D83H	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	83					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GACCTCAGCTGACAGAGAAAC	0.463													C	210518141	C	C	210518141	3	2	182	1	0	0	0	0	1	0	0	0	9235	1290	45	5	249	5	MAP2	2	210518141	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	31055405	210518141	32681232	12	12927											
ST3GAL6	10402	broad.mit.edu	37	chr3	98506930	98506930	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaagaagttgggagaaggaCaaccttccgacttttttatc	10	7	0	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr3:98506930C>T	uc003dsz.2	+	7	718	c.482C>T	c.(481-483)ACA>ATA	p.T161I	ST3GAL6_uc003dsy.2_Missense_Mutation_p.T75I|ST3GAL6_uc003dta.2_Missense_Mutation_p.T43I|ST3GAL6_uc003dtb.2_Missense_Mutation_p.T17I|ST3GAL6_uc003dtc.2_Missense_Mutation_p.T161I|ST3GAL6_uc010hpd.2_Missense_Mutation_p.T214I	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	161	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						GGGAGAAGGACAACCTTCCGA	0.378													T	98506930	T	T	98506930	3	4	182	1	0	0	0	0	1	0	0	0	15218	478	17	3	504	3	ST3GAL6	3	98506930	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08		98506930	99515500	13	12928											
MYLK	4638	broad.mit.edu	37	chr3	123457797	123457797	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgatcttgcaggagaatcGtcccatctgtccttctttga	9	10	3	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr3:123457797G>A	uc003ego.2	-	7	817	c.535C>T	c.(535-537)CGA>TGA	p.R179*	MYLK_uc011bjw.1_Nonsense_Mutation_p.R179*|MYLK_uc003egp.2_Nonsense_Mutation_p.R179*|MYLK_uc003egq.2_Nonsense_Mutation_p.R179*|MYLK_uc003egr.2_Nonsense_Mutation_p.R179*|MYLK_uc003egs.2_Nonsense_Mutation_p.R3*|MYLK_uc010hrs.1_Nonsense_Mutation_p.R179*	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	179	Ig-like C2-type 2.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CAGGAGAATCGTCCCATCTGT	0.562													A	123457797	A	A	123457797	4	1	182	1	0	0	0	0	0	1	0	0	10056	1153	40	1	5321	1	MYLK	3	123457797	Nonsense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	24950867	123457797	74564633	14	12929											
DCUN1D4	23142	broad.mit.edu	37	chr4	52765498	52765498	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aagatcattcttaaatgattCtacaaactttaaacttattt	2	6	3	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr4:52765498C>G	uc003gze.2	+	8	702	c.569C>G	c.(568-570)TCT>TGT	p.S190C	DCUN1D4_uc003gzf.2_Missense_Mutation_p.S190C|DCUN1D4_uc011bzn.1_Missense_Mutation_p.S130C|DCUN1D4_uc003gzg.2_RNA|DCUN1D4_uc003gzh.2_RNA|DCUN1D4_uc011bzo.1_Missense_Mutation_p.S234C	NM_001040402	NP_001035492	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain	190	DCUN1.									ovary(2)	2			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			TTAAATGATTCTACAAACTTT	0.348													G	52765498	G	G	52765498	3	3	182	1	0	0	0	0	1	0	0	0	4316	913	32	5	599	5	DCUN1D4	4	52765498	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08		52765498	138388778	15	12930											
EPHA5	2044	broad.mit.edu	37	chr4	66233108	66233108	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaaatgcatcttttcctcttCtggatcttgttttgctttgc	6	9	4	0			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr4:66233108C>T	uc003hcy.2	-	10	2084	c.1891G>A	c.(1891-1893)GAA>AAA	p.E631K	EPHA5_uc003hcx.2_Missense_Mutation_p.E563K|EPHA5_uc003hcz.2_Missense_Mutation_p.E609K|EPHA5_uc011cah.1_Missense_Mutation_p.E632K|EPHA5_uc011cai.1_Missense_Mutation_p.E610K|EPHA5_uc003hda.2_Missense_Mutation_p.E632K	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	631	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TTTTCCTCTTCTGGATCTTGT	0.358										TSP Lung(17;0.13)			T	66233108	T	T	66233108	3	4	182	1	0	0	0	0	1	0	0	0	5170	922	32	3	1258	3	EPHA5	4	66233108	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	13467610	66233108	124921168	16	12931											
SULT1B1	27284	broad.mit.edu	37	chr4	70596362	70596362	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catcattcaggttcttctctAgaaatctaatgatcttcttg	5	9	7	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr4:70596362A>G	uc003hen.2	-	7	933	c.635T>C	c.(634-636)CTA>CCA	p.L212P		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	212	PAPS (By similarity).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						GTTCTTCTCTAGAAATCTAAT	0.338													G	70596362	G	G	70596362	3	3	182	1	0	0	0	0	1	0	0	0	15373	420	15	4	263	4	SULT1B1	4	70596362	Missense_Mutation	SNP	A	TCGA-27-1830-01A-01W-0643-08	4363254	70596362	120557914	17	12932			1	34		2	2	22	A		4.273614e-05
SULT1B1	27284	broad.mit.edu	37	chr4	70596383	70596383	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaatctaatgatcttcttgAtttcctcctttggattctat	5	8	4	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr4:70596383A>C	uc003hen.2	-	7	912	c.614T>G	c.(613-615)ATC>AGC	p.I205S		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	205	PAPS (By similarity).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						GATCTTCTTGATTTCCTCCTT	0.328													C	70596383	C	C	70596383	3	2	182	1	0	0	0	0	1	0	0	0	15373	333	12	5	284	5	SULT1B1	4	70596383	Missense_Mutation	SNP	A	TCGA-27-1830-01A-01W-0643-08	21	70596383	120557893	18	12933			1	34		2	2	22	A		4.273614e-05
C4orf35	85438	broad.mit.edu	37	chr4	71201006	71201006	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagaagatgatatggggaccGactttattaagtcaacaact	9	7	1	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr4:71201006G>A	uc003hff.2	+	1	336	c.250G>A	c.(250-252)GAC>AAC	p.D84N		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	84						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				TATGGGGACCGACTTTATTAA	0.363													A	71201006	A	A	71201006	3	1	182	1	0	0	0	0	1	0	0	0	2265	1058	37	2	252	2	C4orf35	4	71201006	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	604623	71201006	119953270	19	12934											
TACR3	6870	broad.mit.edu	37	chr4	104510963	104510963	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggcgttgctcttttcttcCgactggacctggtggtgtct	12	10	3	0			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr4:104510963C>T	uc003hxe.1	-	5	1417	c.1274G>A	c.(1273-1275)CGG>CAG	p.R425Q		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	425	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TCTTTTCTTCCGACTGGACCT	0.502													T	104510963	T	T	104510963	3	4	182	1	0	0	0	0	1	0	0	0	15504	652	23	2	127	2	TACR3	4	104510963	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	33309957	104510963	86643313	20	12935											
NDST3	9348	broad.mit.edu	37	chr4	119064755	119064755	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cttttcactcacaccattttCtacaaagaatatccaggggg	6	11	3	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr4:119064755C>T	uc003ibx.2	+	6	1858	c.1455C>T	c.(1453-1455)TTC>TTT	p.F485F	NDST3_uc011cgf.1_Silent_p.F404F	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	485	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						ACACCATTTTCTACAAAGAAT	0.383													T	119064755	T	T	119064755	2	4	182	1	0	0	0	0	0	0	0	1	10257	912	32	3		3	NDST3	4	119064755	Silent	SNP	C	TCGA-27-1830-01A-01W-0643-08	14553792	119064755	72089521	21	12936											
DNAH5	1767	broad.mit.edu	37	chr5	13841162	13841162	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgattagttttctgcatgatTtttttatcaaacttggcatt	6	5	2	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr5:13841162T>A	uc003jfd.2	-	34	5604	c.5562A>T	c.(5560-5562)AAA>AAT	p.K1854N		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1854	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTGCATGATTTTTTTATCAA	0.398									Kartagener_syndrome				A	13841162	A	A	13841162	3	1	182	1	0	0	0	0	1	0	0	0	4604	1838	64	5	8496	5	DNAH5	5	13841162	Missense_Mutation	SNP	T	TCGA-27-1830-01A-01W-0643-08		13841162	167074098	22	12937											
MCCC2	64087	broad.mit.edu	37	chr5	70945048	70945048	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgggggctcctatggagcCggaaactatgggatgtgtgg	17	6	0	0			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr5:70945048C>T	uc003kbs.3	+	14	1479	c.1341C>T	c.(1339-1341)GCC>GCT	p.A447A	MCCC2_uc003kbt.3_RNA	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	447	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	CCTATGGAGCCGGAAACTATG	0.463													T	70945048	T	T	70945048	2	4	182	1	0	0	0	0	0	0	0	1	9375	639	23	2		2	MCCC2	5	70945048	Silent	SNP	C	TCGA-27-1830-01A-01W-0643-08	57103886	70945048	109970212	23	12938											
SLC22A5	6584	broad.mit.edu	37	chr5	131729366	131729366	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggctccgtctgctttgccatAggtgcctacgaccgcttcct	10	15	1	0			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr5:131729366A>G	uc003kww.3	+	9	1715	c.1451_splice	c.e9-2	p.G484_splice	SLC22A5_uc003kwx.3_Splice_Site_p.G508_splice|SLC22A5_uc010jdr.1_Splice_Site_p.G104_splice	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5						positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GCTTTGCCATAGGTGCCTACG	0.562													G	131729366	G	G	131729366	5	3	182	1	0	0	0	0	0	0	1	0	14457	434	15	4	1483	4	SLC22A5	5	131729366	Splice_Site	SNP	A	TCGA-27-1830-01A-01W-0643-08	60784318	131729366	49185894	24	12939											
MAT2B	27430	broad.mit.edu	37	chr5	162945327	162945327	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcaaagaatcactttggccTttcctcattgacaagagatg	7	9	3	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr5:162945327T>G	uc003lzk.2	+	7	1071	c.963T>G	c.(961-963)CCT>CCG	p.P321P	MAT2B_uc003lzj.2_Silent_p.P310P|MAT2B_uc003lzl.1_3'UTR|MAT2B_uc003lzm.2_Silent_p.P61P	NM_013283	NP_037415	Q9NZL9	MAT2B_HUMAN	methionine adenosyltransferase II, beta isoform	321					extracellular polysaccharide biosynthetic process|methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol|methionine adenosyltransferase complex|nucleus	dTDP-4-dehydrorhamnose reductase activity|methionine adenosyltransferase regulator activity|protein binding			upper_aerodigestive_tract(1)	1	Renal(175;0.000281)	Medulloblastoma(196;0.0208)|all_neural(177;0.0765)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.027)|OV - Ovarian serous cystadenocarcinoma(192;0.0406)|Epithelial(171;0.0797)	L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	CACTTTGGCCTTTCCTCATTG	0.388													G	162945327	G	G	162945327	2	3	182	1	0	0	0	0	0	0	0	1	9331	1596	56	5		5	MAT2B	5	162945327	Silent	SNP	T	TCGA-27-1830-01A-01W-0643-08	31215961	162945327	17969933	25	12940											
PKHD1	5314	broad.mit.edu	37	chr6	51941121	51941121	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgaacgatgggtgtctgcGccttggaaaactgtttagaa	14	6	1	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr6:51941121G>A	uc003pah.1	-	6	677	c.401C>T	c.(400-402)GCG>GTG	p.A134V	PKHD1_uc003pai.2_Missense_Mutation_p.A134V	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	134	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGGTGTCTGCGCCTTGGAAAA	0.393													A	51941121	A	A	51941121	3	1	182	1	0	0	0	0	1	0	0	0	11971	1087	38	1	12110	1	PKHD1	6	51941121	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08		51941121	119173946	26	12941											
IBTK	25998	broad.mit.edu	37	chr6	82924066	82924066	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgctcttctgcctctcactAactgtttgagcttgattact	6	11	3	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr6:82924066A>C	uc003pjl.1	-	12	2609	c.2082T>G	c.(2080-2082)GTT>GTG	p.V694V	IBTK_uc011dyv.1_Silent_p.V694V|IBTK_uc011dyw.1_Intron|IBTK_uc010kbi.1_Silent_p.V388V|IBTK_uc003pjm.2_Silent_p.V694V	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	694					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		GCCTCTCACTAACTGTTTGAG	0.338													C	82924066	C	C	82924066	2	2	182	1	0	0	0	0	0	0	0	1	7476	349	13	5		5	IBTK	6	82924066	Silent	SNP	A	TCGA-27-1830-01A-01W-0643-08	30982945	82924066	88191001	27	12942											
SESN1	27244	broad.mit.edu	37	chr6	109319765	109319765	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcatccacactgtgattgCcatttgtaatgtcacagatg	7	10	2	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr6:109319765C>T	uc003pst.3	-	5	838	c.746G>A	c.(745-747)GGC>GAC	p.G249D	SESN1_uc003psu.2_Missense_Mutation_p.G308D	NM_014454	NP_055269	Q9Y6P5	SESN1_HUMAN	sestrin 1	249					cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				ovary(1)	1		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)		ACTGTGATTGCCATTTGTAAT	0.398													T	109319765	T	T	109319765	3	4	182	1	0	0	0	0	1	0	0	0	14124	739	26	3	756	3	SESN1	6	109319765	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	26395699	109319765	61795302	28	12943											
ZNF804B	219578	broad.mit.edu	37	chr7	88966247	88966247	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatcctttaatccaaccagtAttccaaggtcaagatttttg	5	9	1	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr7:88966247A>G	uc011khi.1	+	4	4489	c.3951A>G	c.(3949-3951)GTA>GTG	p.V1317V		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1317						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TCCAACCAGTATTCCAAGGTC	0.413										HNSCC(36;0.09)			G	88966247	G	G	88966247	2	3	182	1	0	0	0	0	0	0	0	1	18168	436	16	4		4	ZNF804B	7	88966247	Silent	SNP	A	TCGA-27-1830-01A-01W-0643-08		88966247	70172416	29	12944											
PPP1R3A	5506	broad.mit.edu	37	chr7	113518248	113518248	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggtttagactcaggataagGgtgcttctcaataccctgga	11	8	2	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr7:113518248G>T	uc010ljy.1	-	4	2930	c.2899C>A	c.(2899-2901)CCT>ACT	p.P967T		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	967					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TCAGGATAAGGGTGCTTCTCA	0.383													T	113518248	T	T	113518248	3	4	182	1	0	0	0	0	1	0	0	0	12371	1232	43	5	473	5	PPP1R3A	7	113518248	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	24552001	113518248	45620415	30	12945											
PLXNA4	91584	broad.mit.edu	37	chr7	131866156	131866156	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacctttaggatgatgggcGtgccaggcttgagctccagg	14	11	0	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr7:131866156G>A	uc003vra.3	-	18	3705	c.3476C>T	c.(3475-3477)ACG>ATG	p.T1159M		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1159	IPT/TIG 4.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GATGATGGGCGTGCCAGGCTT	0.582													A	131866156	A	A	131866156	3	1	182	1	0	0	0	0	1	0	0	0	12122	1145	40	1	2268	1	PLXNA4	7	131866156	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	18347908	131866156	27272507	31	12946											
GIMAP8	155038	broad.mit.edu	37	chr7	150171329	150171329	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttcgatcattgatgctccGgacatctcatctttaaagaa	7	9	3	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr7:150171329G>A	uc003whj.2	+	4	1242	c.912G>A	c.(910-912)CCG>CCA	p.P304P		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	304						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TTGATGCTCCGGACATCTCAT	0.458													A	150171329	A	A	150171329	2	1	182	1	0	0	0	0	0	0	0	1	6385	1103	39	2		2	GIMAP8	7	150171329	Silent	SNP	G	TCGA-27-1830-01A-01W-0643-08	18305173	150171329	8967334	32	12947											
TEX15	56154	broad.mit.edu	37	chr8	30702861	30702861	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcatttattacttcattagCgtcacaactgttttctttag	4	8	4	0			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr8:30702861C>T	uc003xil.2	-	1	3673	c.3673G>A	c.(3673-3675)GCT>ACT	p.A1225T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1225										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ACTTCATTAGCGTCACAACTG	0.299													T	30702861	T	T	30702861	3	4	182	1	0	0	0	0	1	0	0	0	15776	768	27	1	4712	1	TEX15	8	30702861	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08		30702861	115661161	33	12948											
FAM135B	51059	broad.mit.edu	37	chr8	139209806	139209806	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtcccgcatgatcaccaggAagtggagacggagaccccgg	14	12	1	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr8:139209806A>G	uc003yuy.2	-	8	947	c.776T>C	c.(775-777)TTC>TCC	p.F259S	FAM135B_uc003yux.2_Missense_Mutation_p.F160S|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	259										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GATCACCAGGAAGTGGAGACG	0.612										HNSCC(54;0.14)			G	139209806	G	G	139209806	3	3	182	1	0	0	0	0	1	0	0	0	5449	246	9	4	3496	4	FAM135B	8	139209806	Missense_Mutation	SNP	A	TCGA-27-1830-01A-01W-0643-08	108506945	139209806	7154216	34	12949											
ZNF79	7633	broad.mit.edu	37	chr9	130206381	130206381	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttccaagacccatgtgtagaGatgccccctggggattcaga	11	11	1	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr9:130206381G>C	uc004bqw.3	+	5	816	c.402G>C	c.(400-402)GAG>GAC	p.E134D	ZNF79_uc011maf.1_Missense_Mutation_p.E110D|ZNF79_uc011mag.1_Missense_Mutation_p.E110D	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CATGTGTAGAGATGCCCCCTG	0.502													C	130206381	C	C	130206381	3	2	182	1	0	0	0	0	1	0	0	0	18158	933	33	5	420	5	ZNF79	9	130206381	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08		130206381	11007050	35	12950											
ANK3	288	broad.mit.edu	37	chr10	61836046	61836046	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttaacggagaagctgatggCgtattagaggaagaacttga	13	4	0	5			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr10:61836046C>T	uc001jky.2	-	37	4785	c.4593G>A	c.(4591-4593)ACG>ACA	p.T1531T	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1531	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AAGCTGATGGCGTATTAGAGG	0.443													T	61836046	T	T	61836046	2	4	182	1	0	0	0	0	0	0	0	1	622	755	27	1		1	ANK3	10	61836046	Silent	SNP	C	TCGA-27-1830-01A-01W-0643-08		61836046	73698701	36	12951											
TLL2	7093	broad.mit.edu	37	chr10	98157009	98157009	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggaactccacccagagccGgctgtccgtggagacgaggg	16	13	0	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr10:98157009G>A	uc001kml.1	-	11	1544	c.1318C>T	c.(1318-1320)CGG>TGG	p.R440W	TLL2_uc009xvf.1_Missense_Mutation_p.R418W	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	440	CUB 1.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		ACCCAGAGCCGGCTGTCCGTG	0.587													A	98157009	A	A	98157009	3	1	182	1	0	0	0	0	1	0	0	0	15943	1115	39	2	1773	2	TLL2	10	98157009	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	36320963	98157009	37377738	37	12952											
RAG1	5896	broad.mit.edu	37	chr11	36596877	36596877	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgagacgctgactgccatcCtgagtcctctcattgctgag	10	13	1	4			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr11:36596877C>T	uc001mwu.3	+	2	2147	c.2023C>T	c.(2023-2025)CTG>TTG	p.L675L	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	675					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GACTGCCATCCTGAGTCCTCT	0.498									Familial_Hemophagocytic_Lymphohistiocytosis				T	36596877	T	T	36596877	2	4	182	1	0	0	0	0	0	0	0	1	13003	680	24	3		3	RAG1	11	36596877	Silent	SNP	C	TCGA-27-1830-01A-01W-0643-08		36596877	98409639	38	12953											
FOLH1	2346	broad.mit.edu	37	chr11	49186293	49186293	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaccaagctgtacatcagCggtgtacaatcaactctcag	8	11	3	0	rs141224157	by1000genomes	TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr11:49186293C>T	uc001ngy.2	-	13	1665	c.1404G>A	c.(1402-1404)CCG>CCA	p.P468P	FOLH1_uc001ngz.2_Silent_p.P468P|FOLH1_uc009yly.2_Silent_p.P453P|FOLH1_uc009ylz.2_Silent_p.P453P|FOLH1_uc009yma.2_Silent_p.P160P	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	468	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TGTACATCAGCGGTGTACAAT	0.284													T	49186293	T	T	49186293	2	4	182	1	0	0	0	0	0	0	0	1	5979	755	27	1		1	FOLH1	11	49186293	Silent	SNP	C	TCGA-27-1830-01A-01W-0643-08	12589416	49186293	85820223	39	12954											
VWF	7450	broad.mit.edu	37	chr12	6127888	6127888	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccctggtagcggatctctcGcacccgctgcaggatgtccc	12	16	1	0	rs61750112		TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr12:6127888G>A	uc001qnn.1	-	28	4946	c.4696C>T	c.(4696-4698)CGA>TGA	p.R1566*	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1566	VWFA 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CGGATCTCTCGCACCCGCTGC	0.473													A	6127888	A	A	6127888	4	1	182	1	0	0	0	0	0	1	0	0	17243	1095	38	1	3845	1	VWF	12	6127888	Nonsense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08		6127888	127724007	40	12955											
CD163L1	283316	broad.mit.edu	37	chr12	7528295	7528295	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagattatttaaaaatctcaCgggaacagacaactccaact	5	9	1	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr12:7528295C>T	uc001qsy.2	-	10	2712	c.2686_splice	c.e10+1	p.R896_splice	CD163L1_uc010sge.1_Splice_Site_p.R906_splice	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						AAAAATCTCACGGGAACAGAC	0.468													T	7528295	T	T	7528295	5	4	182	1	0	0	0	0	0	0	1	0	2968	550	19	1	1714	1	CD163L1	12	7528295	Splice_Site	SNP	C	TCGA-27-1830-01A-01W-0643-08	1400407	7528295	126323600	41	12956											
KRT8	3856	broad.mit.edu	37	chr12	53294405	53294405	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcctgaggaagttgatctcGtcggtcagcccttccaggcg	13	12	2	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr12:53294405G>A	uc001sbd.2	-	4	760	c.657C>T	c.(655-657)GAC>GAT	p.D219D	KRT8_uc009zmj.2_Silent_p.D219D|KRT8_uc009zmk.1_Silent_p.D247D|KRT8_uc009zml.1_Silent_p.D219D|KRT8_uc009zmm.1_Silent_p.D219D	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	219	Coil 1B.|Rod.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTTGATCTCGTCGGTCAGCC	0.572													A	53294405	A	A	53294405	2	1	182	1	0	0	0	0	0	0	0	1	8493	1136	40	1		1	KRT8	12	53294405	Silent	SNP	G	TCGA-27-1830-01A-01W-0643-08	45766110	53294405	80557490	42	12957											
IRAK3	11213	broad.mit.edu	37	chr12	66597512	66597512	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagagactttcaagcagctGgctggatgttcgtcatattg	12	7	2	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr12:66597512G>A	uc001sth.2	+	2	257	c.155G>A	c.(154-156)TGG>TAG	p.W52*	IRAK3_uc010ssy.1_Intron	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	52	Death.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		TCAAGCAGCTGGCTGGATGTT	0.363													A	66597512	A	A	66597512	4	1	182	1	0	0	0	0	0	1	0	0	7824	1357	47	3	161	3	IRAK3	12	66597512	Nonsense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	13303107	66597512	67254383	43	12958											
SBNO1	55206	broad.mit.edu	37	chr12	123794321	123794321	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaactgcagtaagtgtgtcCgcaaaatactgaaataacgc	8	9	0	1	rs145298684	by1000genomes	TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr12:123794321C>T	uc010tap.1	-	25	3378	c.3378G>A	c.(3376-3378)GCG>GCA	p.A1126A	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Silent_p.A1125A|SBNO1_uc010taq.1_Silent_p.A77A|SBNO1_uc001ues.1_Silent_p.A77A	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1126							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TAAGTGTGTCCGCAAAATACT	0.358													T	123794321	T	T	123794321	2	4	182	1	0	0	0	0	0	0	0	1	13862	639	23	2		2	SBNO1	12	123794321	Silent	SNP	C	TCGA-27-1830-01A-01W-0643-08	57196809	123794321	10057574	44	12959											
CLCN7	1186	broad.mit.edu	37	chr16	1498997	1498997	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtcgcccacgatcttggcGgtcatgagcaccagcatgat	11	13	2	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr16:1498997G>A	uc002clv.2	-	19	1877	c.1767C>T	c.(1765-1767)ACC>ACT	p.T589T	CLCN7_uc010brq.1_5'Flank|CLCN7_uc002clu.2_Silent_p.T37T|CLCN7_uc002clw.2_Silent_p.T565T	NM_001287	NP_001278	P51798	CLCN7_HUMAN	chloride channel 7 isoform a	589	Helical; (By similarity).					integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Hepatocellular(780;0.0893)				CGATCTTGGCGGTCATGAGCA	0.632													A	1498997	A	A	1498997	2	1	182	1	0	0	0	0	0	0	0	1	3468	1103	39	2		2	CLCN7	16	1498997	Silent	SNP	G	TCGA-27-1830-01A-01W-0643-08		1498997	88855756	45	12960											
CLCN7	1186	broad.mit.edu	37	chr16	1510943	1510943	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcttgatctccaccgtccGgaaggcctgcagggcgcggt	15	14	1	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr16:1510943G>A	uc002clv.2	-	5	468	c.358C>T	c.(358-360)CGG>TGG	p.R120W	CLCN7_uc002clw.2_Missense_Mutation_p.R96W	NM_001287	NP_001278	P51798	CLCN7_HUMAN	chloride channel 7 isoform a	120	Cytoplasmic (By similarity).					integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Hepatocellular(780;0.0893)				TCCACCGTCCGGAAGGCCTGC	0.682													A	1510943	A	A	1510943	3	1	182	1	0	0	0	0	1	0	0	0	3468	1115	39	2	2143	2	CLCN7	16	1510943	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	11946	1510943	88843810	46	12961											
ZNF19	7567	broad.mit.edu	37	chr16	71509676	71509676	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgatgtataacaaactcGgaactactcgtgaaactatt	6	9	1	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr16:71509676G>A	uc010cgc.1	-	6	1280	c.774C>T	c.(772-774)TCC>TCT	p.S258S	ZNF23_uc002fai.2_Intron|ZNF19_uc002fak.1_Silent_p.S246S|ZNF19_uc002fal.1_Silent_p.S246S|ZNF19_uc002fam.1_Silent_p.S258S	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	258	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		TAACAAACTCGGAACTACTCG	0.438													A	71509676	A	A	71509676	2	1	182	1	0	0	0	0	0	0	0	1	17752	1103	39	2		2	ZNF19	16	71509676	Silent	SNP	G	TCGA-27-1830-01A-01W-0643-08	69998733	71509676	18845077	47	12962											
CHST6	4166	broad.mit.edu	37	chr16	75513068	75513068	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcacgatgccgttgtcaCgcgccagagccttggctgtc	12	15	1	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr16:75513068C>T	uc002fef.2	-	3	839	c.659G>A	c.(658-660)CGT>CAT	p.R220H	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.R220H	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	220	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GCCGTTGTCACGCGCCAGAGC	0.721													T	75513068	T	T	75513068	3	4	182	1	0	0	0	0	1	0	0	0	3408	536	19	1	532	1	CHST6	16	75513068	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	4003392	75513068	14841685	48	12963											
SLC38A8	146167	broad.mit.edu	37	chr16	84066963	84066963	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctggaaggcgatctcccgcGgggcagacaggggcaggatg	18	10	2	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr16:84066963G>A	uc002fhg.1	-	3	500	c.500C>T	c.(499-501)CCG>CTG	p.P167L		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	167	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0						GATCTCCCGCGGGGCAGACAG	0.652													A	84066963	A	A	84066963	3	1	182	1	0	0	0	0	1	0	0	0	14610	1116	39	2	839	2	SLC38A8	16	84066963	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	8553895	84066963	6287790	49	12964											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577538	T	T	7577538	3	4	182	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08		7577538	73617672	50	12965											
MSL1	339287	broad.mit.edu	37	chr17	38285515	38285515	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taggaaatccccatttggaaGtacagaaagaaagactcctg	9	8	0	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr17:38285515G>A	uc002hub.2	+	3	426	c.407G>A	c.(406-408)AGT>AAT	p.S136N	MSL1_uc002hua.3_Missense_Mutation_p.S74N|MSL1_uc002huc.2_Missense_Mutation_p.S74N|MSL1_uc002hud.2_5'Flank	NM_001012241	NP_001012241	Q68DK7	MSL1_HUMAN	hampin	337					histone H4-K16 acetylation	MSL complex					0						CCATTTGGAAGTACAGAAAGA	0.333													A	38285515	A	A	38285515	3	1	182	1	0	0	0	0	1	0	0	0	9877	1029	36	3	227	3	MSL1	17	38285515	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	30707977	38285515	42909695	51	12966											
IFI35	3430	broad.mit.edu	37	chr17	41166266	41166266	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtagaggccctgacagtcGtaccccaaggacagcagggc	14	12	0	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr17:41166266G>A	uc010whj.1	+	7	1013	c.817G>A	c.(817-819)GTA>ATA	p.V273I		NM_005533	NP_005524	P80217	IN35_HUMAN	interferon-induced protein 35	271				EVEALTVVPQGQQGLAVFTSESG -> GRGPDSRTPRTAGP SSLHL (in Ref. 1; no nucleotide entry).	response to virus|type I interferon-mediated signaling pathway	nucleus	protein binding			ovary(1)	1		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.157)		CCTGACAGTCGTACCCCAAGG	0.632													A	41166266	A	A	41166266	3	1	182	1	0	0	0	0	1	0	0	0	7516	1145	40	1	843	1	IFI35	17	41166266	Missense_Mutation	SNP	G	TCGA-27-1830-01A-01W-0643-08	2880751	41166266	40028944	52	12967											
ACE	1636	broad.mit.edu	37	chr17	61566027	61566027	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatctgacgaatgtgatggCcacgtcccggaaatatgaag	12	8	1	4			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr17:61566027C>T	uc002jau.1	+	16	2346	c.2324C>T	c.(2323-2325)GCC>GTC	p.A775V	ACE_uc002jav.1_Missense_Mutation_p.A201V|ACE_uc010ddv.1_Missense_Mutation_p.A2V|ACE_uc010wpj.1_Missense_Mutation_p.A201V|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.A85V	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	775	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	AATGTGATGGCCACGTCCCGG	0.542													T	61566027	T	T	61566027	3	4	182	1	0	0	0	0	1	0	0	0	136	739	26	3	2589	3	ACE	17	61566027	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	20399761	61566027	19629183	53	12968											
DSG3	1830	broad.mit.edu	37	chr18	29054117	29054117	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacgtatgccagaggcacagCggtggaaggcacttcaggaa	14	9	1	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr18:29054117C>T	uc002kws.2	+	15	2244	c.2135C>T	c.(2134-2136)GCG>GTG	p.A712V	DSG3_uc002kwt.2_5'UTR	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	712	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGAGGCACAGCGGTGGAAGGC	0.443													T	29054117	T	T	29054117	3	4	182	1	0	0	0	0	1	0	0	0	4778	768	27	1	2193	1	DSG3	18	29054117	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08		29054117	49023131	54	12969											
ATP5A1	498	broad.mit.edu	37	chr18	43667414	43667414	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caggtactgaagtggggcagCatccgaggccgtagccgaca	15	11	0	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr18:43667414C>A	uc002lbr.1	-	7	934	c.844G>T	c.(844-846)GCT>TCT	p.A282S	ATP5A1_uc010dnl.1_Missense_Mutation_p.A232S|ATP5A1_uc002lbs.1_Missense_Mutation_p.A232S|ATP5A1_uc002lbt.1_Missense_Mutation_p.A282S	NM_004046	NP_004037	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	282					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0						AGTGGGGCAGCATCCGAGGCC	0.423													A	43667414	A	A	43667414	3	1	182	1	0	0	0	0	1	0	0	0	1147	710	25	5	841	5	ATP5A1	18	43667414	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	14613297	43667414	34409834	55	12970											
C19orf50	79036	broad.mit.edu	37	chr19	18675766	18675766	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagcagatgagcgaacgcttCctgcaccacacgaggaccct	10	15	0	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr19:18675766C>T	uc002njo.2	+	3	331	c.189C>T	c.(187-189)TTC>TTT	p.F63F	C19orf50_uc002njp.2_RNA|C19orf50_uc002njq.2_Silent_p.F63F	NM_024069	NP_076974	Q9BQD3	CS050_HUMAN	hypothetical protein LOC79036	63							protein binding				0						GCGAACGCTTCCTGCACCACA	0.582													T	18675766	T	T	18675766	2	4	182	1	0	0	0	0	0	0	0	1	1932	854	30	3		3	C19orf50	19	18675766	Silent	SNP	C	TCGA-27-1830-01A-01W-0643-08		18675766	40453217	56	12971											
ZNF429	353088	broad.mit.edu	37	chr19	21712573	21712573	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgttagagaactacagaaaCttggtcttcctgggtgagaa	11	6	1	3			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr19:21712573C>A	uc002nqd.1	+	2	254	c.117C>A	c.(115-117)AAC>AAA	p.N39K	ZNF429_uc010ecu.1_Missense_Mutation_p.N39K	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						ACTACAGAAACTTGGTCTTCC	0.378													A	21712573	A	A	21712573	3	1	182	1	0	0	0	0	1	0	0	0	17899	564	20	5	123	5	ZNF429	19	21712573	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	3036807	21712573	37416410	57	12972											
TMEM149	79713	broad.mit.edu	37	chr19	36230669	36230669	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtcccctgtctccagggcGcctggggaggacagatgcga	16	12	1	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr19:36230669G>A	uc002obc.2	-	4	764	c.663C>T	c.(661-663)GGC>GGT	p.G221G	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Silent_p.G221G|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Silent_p.G301G	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	221	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTCCAGGGCGCCTGGGGAGG	0.642													A	36230669	A	A	36230669	2	1	182	1	0	0	0	0	0	0	0	1	16059	1074	38	1		1	TMEM149	19	36230669	Silent	SNP	G	TCGA-27-1830-01A-01W-0643-08	14518096	36230669	22898314	58	12973											
CPT1C	126129	broad.mit.edu	37	chr19	50208532	50208532	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgagaagatcttcaacaccaCgcggattccaggggtccaaa	10	12	2	2			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr19:50208532C>T	uc002ppj.2	+	9	1146	c.941C>T	c.(940-942)ACG>ATG	p.T314M	CPT1C_uc002ppl.3_Missense_Mutation_p.T280M|CPT1C_uc002ppi.2_Missense_Mutation_p.T231M|CPT1C_uc002ppk.2_Missense_Mutation_p.T303M|CPT1C_uc010eng.2_Missense_Mutation_p.T314M|CPT1C_uc010enh.2_Missense_Mutation_p.T314M|CPT1C_uc010ybc.1_Missense_Mutation_p.T185M|CPT1C_uc010eni.1_5'Flank	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	314	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTCAACACCACGCGGATTCCA	0.448													T	50208532	T	T	50208532	3	4	182	1	0	0	0	0	1	0	0	0	3833	536	19	1	971	1	CPT1C	19	50208532	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	13977863	50208532	8920451	59	12974											
XKR7	343702	broad.mit.edu	37	chr20	30584473	30584473	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcccgcggcctggccttcgCgctcttcgccagcgtctaca	11	19	2	0			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr20:30584473C>T	uc002wxe.2	+	3	1127	c.953C>T	c.(952-954)GCG>GTG	p.A318V		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	318	Helical; (Potential).					integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CTGGCCTTCGCGCTCTTCGCC	0.637													T	30584473	T	T	30584473	3	4	182	1	0	0	0	0	1	0	0	0	17433	768	27	1	963	1	XKR7	20	30584473	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08		30584473	32441047	60	12975											
JPH2	57158	broad.mit.edu	37	chr20	42788430	42788430	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gccctcctcgcggtggccgtCgggcagcgtggtgcagccat	16	15	0	0			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr20:42788430C>T	uc002xli.1	-	2	1870	c.997G>A	c.(997-999)GAC>AAC	p.D333N		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	333	MORN 8.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGGTGGCCGTCGGGCAGCGTG	0.662													T	42788430	T	T	42788430	3	4	182	1	0	0	0	0	1	0	0	0	7961	884	31	2	1109	2	JPH2	20	42788430	Missense_Mutation	SNP	C	TCGA-27-1830-01A-01W-0643-08	12203957	42788430	20237090	61	12976											
PCBP3	54039	broad.mit.edu	37	chr21	47349908	47349908	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagaccaaccccgctttcccCggtacgtacccagccctttt	6	19	0	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chr21:47349908C>A	uc002zhq.1	+	10	920	c.795C>A	c.(793-795)CCC>CCA	p.P265P	PCBP3_uc010gqb.2_Silent_p.P265P|PCBP3_uc002zhp.1_Silent_p.P265P|PCBP3_uc002zhs.1_Silent_p.P239P|PCBP3_uc002zhr.1_Silent_p.P264P|PCBP3_uc002zht.1_Silent_p.P255P	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	265					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		CCGCTTTCCCCGGTACGTACC	0.567													A	47349908	A	A	47349908	2	1	182	1	0	0	0	0	0	0	0	1	11502	666	23	5		5	PCBP3	21	47349908	Silent	SNP	C	TCGA-27-1830-01A-01W-0643-08		47349908	779987	62	12977											
ZCCHC5	203430	broad.mit.edu	37	chrX	77913028	77913028	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctccagtaaggggctttggAtatccagtaagagctggaac	13	8	0	1			TCGA-27-1830-01A-01W-0643-08	TCGA-27-1830-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	b391392a-9865-4bf4-b5f1-fa4fb2ad1343	79d0add1-1203-45bd-a50e-3ab5bcacc03d	g.chrX:77913028A>G	uc004edc.1	-	2	1186	c.890T>C	c.(889-891)ATC>ACC	p.I297T		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	297							nucleic acid binding|zinc ion binding			ovary(1)	1						GGGGCTTTGGATATCCAGTAA	0.483													G	77913028	G	G	77913028	3	3	182	1	0	0	0	0	1	0	0	0	17588	333	12	4	541	4	ZCCHC5	23	77913028	Missense_Mutation	SNP	A	TCGA-27-1830-01A-01W-0643-08		77913028	77357532	63	12978											
AGMAT	79814	broad.mit.edu	37	chr1	15904246	15904246	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcataggcaggatccagagcGtcaatatcaaagctgatata	10	8	2	2	rs148750290	by1000genomes	TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:15904246G>A	uc001awv.1	-	5	977	c.834C>T	c.(832-834)GAC>GAT	p.D278D	DNAJC16_uc001awu.2_Intron	NM_024758	NP_079034	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase) precursor	278		Manganese 2 (By similarity).			putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			skin(1)	1		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		GATCCAGAGCGTCAATATCAA	0.532													A	15904246	A	A	15904246	2	1	183	1	0	0	0	0	0	0	0	1	385	1136	40	1		1	AGMAT	1	15904246	Silent	SNP	G	TCGA-27-1831-01A-01D-1494-08		15904246	233346375	1	12979											
EPHA8	2046	broad.mit.edu	37	chr1	22924647	22924647	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctactgcccgcccaggccGcctggcaatgattgtgactg	11	16	0	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:22924647G>A	uc001bfx.1	+	12	2245	c.2120G>A	c.(2119-2121)CGC>CAC	p.R707H		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	707	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CGCCCAGGCCGCCTGGCAATG	0.622													A	22924647	A	A	22924647	3	1	183	1	0	0	0	0	1	0	0	0	5173	1087	38	1	2339	1	EPHA8	1	22924647	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	7020401	22924647	226325974	2	12980											
HTR1D	3352	broad.mit.edu	37	chr1	23520071	23520071	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tagatccggccatataggatGatgagcaacaccgagggaat	12	8	0	3			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:23520071G>A	uc001bgn.2	-	1	1152	c.642C>T	c.(640-642)ATC>ATT	p.I214I		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	214	Helical; Name=5; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	CATATAGGATGATGAGCAACA	0.577													A	23520071	A	A	23520071	2	1	183	1	0	0	0	0	0	0	0	1	7438	1280	45	3		3	HTR1D	1	23520071	Silent	SNP	G	TCGA-27-1831-01A-01D-1494-08	595424	23520071	225730550	3	12981											
KLHDC9	126823	broad.mit.edu	37	chr1	161068632	161068632	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggctgggacgggtctcgcCgcttggccacagtgaccgca	16	14	1	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:161068632C>T	uc001fxr.2	+	1	479	c.307C>T	c.(307-309)CGC>TGC	p.R103C	KLHDC9_uc001fxq.2_5'UTR|KLHDC9_uc001fxs.2_Missense_Mutation_p.R103C	NM_152366	NP_689579	Q8NEP7	KLDC9_HUMAN	kelch/ankyrin repeat containing cyclin A1	103	Kelch 2.										0	all_cancers(52;1.28e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CGGGTCTCGCCGCTTGGCCAC	0.726													T	161068632	T	T	161068632	3	4	183	1	0	0	0	0	1	0	0	0	8364	652	23	2	309	2	KLHDC9	1	161068632	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	137548561	161068632	88181989	4	12982											
ADAMTS4	9507	broad.mit.edu	37	chr1	161165991	161165991	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agcagcagtgaaggctgactGgagcccatcatcctccacaa	10	13	1	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:161165991G>T	uc001fyt.3	-	3	1488	c.1060C>A	c.(1060-1062)CAG>AAG	p.Q354K	ADAMTS4_uc001fyu.2_3'UTR	NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	354	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AAGGCTGACTGGAGCCCATCA	0.577													T	161165991	T	T	161165991	3	4	183	1	0	0	0	0	1	0	0	0	268	1357	47	5	1481	5	ADAMTS4	1	161165991	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	97359	161165991	88084630	5	12983											
SLC9A11	284525	broad.mit.edu	37	chr1	173552735	173552735	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gatcaatgattctcctctaaTgagatcaatgtatattttag	6	6	4	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:173552735T>A	uc001giz.2	-	6	973	c.550A>T	c.(550-552)ATT>TTT	p.I184F	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	184	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TCTCCTCTAATGAGATCAATG	0.294													A	173552735	A	A	173552735	3	1	183	1	0	0	0	0	1	0	0	0	14711	1464	51	5	2916	5	SLC9A11	1	173552735	Missense_Mutation	SNP	T	TCGA-27-1831-01A-01D-1494-08	12386744	173552735	75697886	6	12984											
KDM5B	10765	broad.mit.edu	37	chr1	202718129	202718129	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctcaatcataatggccatgtCtttctgaacagttgaagcca	7	10	4	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:202718129C>A	uc001gyf.2	-	14	2076	c.1960G>T	c.(1960-1962)GAC>TAC	p.D654Y	KDM5B_uc009xag.2_Missense_Mutation_p.D690Y|KDM5B_uc001gyg.1_Missense_Mutation_p.D496Y	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	654					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						ATGGCCATGTCTTTCTGAACA	0.403													A	202718129	A	A	202718129	3	1	183	1	0	0	0	0	1	0	0	0	8134	913	32	5	2730	5	KDM5B	1	202718129	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	29165394	202718129	46532492	7	12985											
USH2A	7399	broad.mit.edu	37	chr1	215972257	215972257	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggccccttacctggaaggCgattgtacaccactccttct	9	14	1	0	rs140746096		TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:215972257C>T	uc001hku.1	-	50	10337	c.9950G>A	c.(9949-9951)CGC>CAC	p.R3317H		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3317	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACCTGGAAGGCGATTGTACAC	0.473										HNSCC(13;0.011)			T	215972257	T	T	215972257	3	4	183	1	0	0	0	0	1	0	0	0	17033	768	27	1	5750	1	USH2A	1	215972257	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	13254128	215972257	33278364	8	12986											
C1orf65	164127	broad.mit.edu	37	chr1	223568231	223568231	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctgaggaaggagcggcaaCgcgagctgagggagaaggcc	19	9	0	3			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:223568231C>T	uc001hoa.2	+	1	1517	c.1414C>T	c.(1414-1416)CGC>TGC	p.R472C		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	472	Potential.									central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		GGAGCGGCAACGCGAGCTGAG	0.607													T	223568231	T	T	223568231	3	4	183	1	0	0	0	0	1	0	0	0	2055	536	19	1	1416	1	C1orf65	1	223568231	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	7595974	223568231	25682390	9	12987											
RYR2	6262	broad.mit.edu	37	chr1	237863751	237863751	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catattggccagcatcagttCggagaagacctaatatgtat	9	8	1	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:237863751C>T	uc001hyl.1	+	65	9471	c.9351C>T	c.(9349-9351)TTC>TTT	p.F3117F	RYR2_uc010pxz.1_Silent_p.F72F	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3117					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCATCAGTTCGGAGAAGACC	0.373													T	237863751	T	T	237863751	2	4	183	1	0	0	0	0	0	0	0	1	13769	883	31	2		2	RYR2	1	237863751	Silent	SNP	C	TCGA-27-1831-01A-01D-1494-08	14295520	237863751	11386870	10	12988											
NLRP3	114548	broad.mit.edu	37	chr1	247587925	247587925	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgatgaggcccaagccaggGcagccttcagtctgattcag	12	12	3	3			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr1:247587925G>T	uc001icr.2	+	5	1318	c.1180G>T	c.(1180-1182)GCA>TCA	p.A394S	NLRP3_uc001ics.2_Missense_Mutation_p.A394S|NLRP3_uc001icu.2_Missense_Mutation_p.A394S|NLRP3_uc001icw.2_Missense_Mutation_p.A394S|NLRP3_uc001icv.2_Missense_Mutation_p.A394S|NLRP3_uc010pyw.1_Missense_Mutation_p.A392S|NLRP3_uc001ict.1_Missense_Mutation_p.A392S	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	394	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CCAAGCCAGGGCAGCCTTCAG	0.537													T	247587925	T	T	247587925	3	4	183	1	0	0	0	0	1	0	0	0	10478	1203	42	5	1190	5	NLRP3	1	247587925	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	9724174	247587925	1662696	11	12989											
KCNS3	3790	broad.mit.edu	37	chr2	18112318	18112318	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atcgccctggacaagacgagGaacttgtcaacctgaatgtg	11	10	1	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr2:18112318G>A	uc002rcv.2	+	3	494	c.43G>A	c.(43-45)GAA>AAA	p.E15K	KCNS3_uc002rcw.2_Missense_Mutation_p.E15K	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	15	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ACAAGACGAGGAACTTGTCAA	0.537													A	18112318	A	A	18112318	3	1	183	1	0	0	0	0	1	0	0	0	8090	1175	41	3	45	3	KCNS3	2	18112318	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08		18112318	225087055	12	12990											
APOB	338	broad.mit.edu	37	chr2	21227512	21227512	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttcctttagtcttagaggCtaacgtaccatcttcgattt	7	9	2	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr2:21227512C>T	uc002red.2	-	27	11952	c.11824G>A	c.(11824-11826)GCC>ACC	p.A3942T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3942					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTCTTAGAGGCTAACGTACCA	0.358													T	21227512	T	T	21227512	3	4	183	1	0	0	0	0	1	0	0	0	785	797	28	3	1879	3	APOB	2	21227512	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	3115194	21227512	221971861	13	12991											
GPD2	2820	broad.mit.edu	37	chr2	157407115	157407115	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgccactttctttcacaggGcaggaatttgacgtgagagc	11	9	2	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr2:157407115G>A	uc002tzf.3	+	8	1188	c.828G>A	c.(826-828)GGG>GGA	p.G276G	GPD2_uc010zch.1_Silent_p.G49G|GPD2_uc002tzd.3_Silent_p.G276G|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	276					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						CTTTCACAGGGCAGGAATTTG	0.438													A	157407115	A	A	157407115	2	1	183	1	0	0	0	0	0	0	0	1	6606	1217	42	3		3	GPD2	2	157407115	Silent	SNP	G	TCGA-27-1831-01A-01D-1494-08	136179603	157407115	85792258	14	12992											
KIAA1486	57624	broad.mit.edu	37	chr2	226447519	226447519	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttacgacgctgtgcattcGggcagcctctcaaggagctc	11	14	1	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr2:226447519G>A	uc002voe.2	+	4	1561	c.1386G>A	c.(1384-1386)TCG>TCA	p.S462S	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Silent_p.S232S	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	462	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		CTGTGCATTCGGGCAGCCTCT	0.622													A	226447519	A	A	226447519	2	1	183	1	0	0	0	0	0	0	0	1	8237	1103	39	2		2	KIAA1486	2	226447519	Silent	SNP	G	TCGA-27-1831-01A-01D-1494-08	69040404	226447519	16751854	15	12993											
UGT1A7	54577	broad.mit.edu	37	chr2	234591304	234591304	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctccaaacccctgtcacgGcatatgatctctacagccac	5	16	3	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr2:234591304G>A	uc002vut.2	+	1	721	c.721G>A	c.(721-723)GCA>ACA	p.A241T	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Missense_Mutation_p.A241T	NM_019077	NP_061950	Q9HAW7	UD17_HUMAN	UDP glycosyltransferase 1 family, polypeptide A7	241					drug metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	drug binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CCCTGTCACGGCATATGATCT	0.413													A	234591304	A	A	234591304	3	1	183	1	0	0	0	0	1	0	0	0	16947	1203	42	3	723	3	UGT1A7	2	234591304	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	8143785	234591304	8608069	16	12994											
COL6A3	1293	broad.mit.edu	37	chr2	238275630	238275630	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gtccaggcggctgcctgcctCaggcacaaagtggtttaccc	12	14	1	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr2:238275630C>A	uc002vwl.2	-	11	5485	c.5200G>T	c.(5200-5202)GAG>TAG	p.E1734*	COL6A3_uc002vwo.2_Nonsense_Mutation_p.E1528*|COL6A3_uc010znj.1_Nonsense_Mutation_p.E1127*	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1734	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTGCCTGCCTCAGGCACAAAG	0.572													A	238275630	A	A	238275630	4	1	183	1	0	0	0	0	0	1	0	0	3701	835	29	5	4469	5	COL6A3	2	238275630	Nonsense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	3684326	238275630	4923743	17	12995											
CDCP1	64866	broad.mit.edu	37	chr3	45132920	45132920	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccacctggtctctgggcaCgctgatgttccaggacacag	13	13	1	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr3:45132920C>T	uc003com.2	-	7	1873	c.1738G>A	c.(1738-1740)GTG>ATG	p.V580M		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	580	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCTCTGGGCACGCTGATGTTC	0.607													T	45132920	T	T	45132920	3	4	183	1	0	0	0	0	1	0	0	0	3093	536	19	1	784	1	CDCP1	3	45132920	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		45132920	152889510	18	12996											
GSK3B	2932	broad.mit.edu	37	chr3	119812236	119812236	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agctgaaggctgctgcaccgGcttgcagctctccgcaaagg	13	13	1	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr3:119812236G>C	uc003edo.2	-	1	1029	c.46C>G	c.(46-48)CCG>GCG	p.P16A	GSK3B_uc003edn.2_Missense_Mutation_p.P16A|uc003edp.2_5'Flank	NM_001146156	NP_001139628	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta isoform 2	16					axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			lung(2)	2				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)	TGCTGCACCGGCTTGCAGCTC	0.483													C	119812236	C	C	119812236	3	2	183	1	0	0	0	0	1	0	0	0	6824	1203	42	5	1303	5	GSK3B	3	119812236	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	74679316	119812236	78210194	19	12997											
WFS1	7466	broad.mit.edu	37	chr4	6302612	6302612	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtgatctgcaccctcaagGtgttccaggacagcaaggcc	12	12	2	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr4:6302612G>A	uc003giy.2	+	8	1256	c.1090G>A	c.(1090-1092)GTG>ATG	p.V364M	WFS1_uc003gix.2_Missense_Mutation_p.V364M|WFS1_uc003giz.2_Missense_Mutation_p.V182M	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	364					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		CACCCTCAAGGTGTTCCAGGA	0.572													A	6302612	A	A	6302612	3	1	183	1	0	0	0	0	1	0	0	0	17357	1261	44	3	1116	3	WFS1	4	6302612	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08		6302612	184851664	20	12998											
TLR6	10333	broad.mit.edu	37	chr4	38830723	38830723	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaatgagagatctaaatgCctgaaactcacaataggatg	9	6	2	4			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr4:38830723C>T	uc003gtm.2	-	1	438	c.372G>A	c.(370-372)AGG>AGA	p.R124R	TLR6_uc010ifg.1_Silent_p.R124R	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	124	LRR 4.|Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						GATCTAAATGCCTGAAACTCA	0.363													T	38830723	T	T	38830723	2	4	183	1	0	0	0	0	0	0	0	1	15952	738	26	3		3	TLR6	4	38830723	Silent	SNP	C	TCGA-27-1831-01A-01D-1494-08	32528111	38830723	152323553	21	12999											
PDGFRA	5156	broad.mit.edu	37	chr4	55155241	55155241	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	accctccttttaccacctgaGtgagattgtggagaatctgc	9	11	1	3			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr4:55155241G>C	uc003han.3	+	21	3171	c.2840G>C	c.(2839-2841)AGT>ACT	p.S947T	PDGFRA_uc003haa.2_Missense_Mutation_p.S707T	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	947	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TACCACCTGAGTGAGATTGTG	0.498			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			C	55155241	C	C	55155241	3	2	183	1	0	0	0	0	1	0	0	0	11661	1029	36	5	2918	5	PDGFRA	4	55155241	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	16324518	55155241	135999035	22	13000											
PDCL2	132954	broad.mit.edu	37	chr4	56435994	56435994	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttctccaaatttttgtttttTcttaagagctttccattcct	3	9	2	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr4:56435994T>C	uc003hbb.2	-	4	356	c.253A>G	c.(253-255)AAA>GAA	p.K85E		NM_152401	NP_689614	Q8N4E4	PDCL2_HUMAN	phosducin-like 2	85											0	Lung NSC(11;0.00256)|Glioma(25;0.08)|all_epithelial(27;0.0863)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.69e-07)|Lung(4;1.03e-06)|Epithelial(7;0.00669)			TTTTGTTTTTTCTTAAGAGCT	0.289													C	56435994	C	C	56435994	3	2	183	1	0	0	0	0	1	0	0	0	11627	1792	62	4	484	4	PDCL2	4	56435994	Missense_Mutation	SNP	T	TCGA-27-1831-01A-01D-1494-08	1280753	56435994	134718282	23	13001											
PPBP	5473	broad.mit.edu	37	chr4	74853312	74853312	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttttgggatgaattccagagGttgtctttatacacatgcag	10	6	1	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr4:74853312G>T	uc003hhj.2	-	2	286	c.206C>A	c.(205-207)ACC>AAC	p.T69N		NM_002704	NP_002695	P02775	CXCL7_HUMAN	pro-platelet basic protein precursor	69					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			AATTCCAGAGGTTGTCTTTAT	0.363													T	74853312	T	T	74853312	3	4	183	1	0	0	0	0	1	0	0	0	12303	1261	44	5	188	5	PPBP	4	74853312	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	18417318	74853312	116300964	24	13002											
TTC29	83894	broad.mit.edu	37	chr4	147824706	147824706	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccactcaccatcttcctcGtagagaagacccatatgcat	6	15	2	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr4:147824706G>A	uc003ikw.3	-	6	803	c.576C>T	c.(574-576)TAC>TAT	p.Y192Y	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Silent_p.Y218Y|TTC29_uc010ipd.1_Silent_p.Y192Y	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	192	TPR 1.						binding				0	all_hematologic(180;0.151)					CATCTTCCTCGTAGAGAAGAC	0.458													A	147824706	A	A	147824706	2	1	183	1	0	0	0	0	0	0	0	1	16693	1140	40	1		1	TTC29	4	147824706	Silent	SNP	G	TCGA-27-1831-01A-01D-1494-08	72971394	147824706	43329570	25	13003											
WWC2	80014	broad.mit.edu	37	chr4	184166575	184166576	+	Frame_Shift_Ins	INS	-	A	A													tctcttttcacagaattgatINSaaaaaaatgtctggaggcca							TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr4:184166575_184166576insA	uc010irx.2	+	6	791_792	c.609_610insA	c.(607-612)GATAAAfs	p.D203fs	WWC2_uc003ivk.3_5'UTR|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Intron	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	203_204										ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		ACAGAATTGATAAAAAAATGTC	0.356													A	184166576	A	A	184166575	7	5	183	1	0	1	1	0	0	0	0	0	17409	1403	49	0	631	0	WWC2	4	184166575	Frame_Shift_Ins	INS	-	TCGA-27-1831-01A-01D-1494-08	36341869	184166575	6987701	26	13004											
CDC20B	166979	broad.mit.edu	37	chr5	54423154	54423154	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccaagcatatttctcagcCgctttttagttaccacatcc	5	13	1	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr5:54423154C>T	uc003jpo.1	-	8	1095	c.920G>A	c.(919-921)CGG>CAG	p.R307Q	CDC20B_uc003jpn.1_Missense_Mutation_p.R307Q|CDC20B_uc010ivu.1_Missense_Mutation_p.R307Q|CDC20B_uc010ivv.1_Missense_Mutation_p.R307Q	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	307	WD 2.										0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			ATTTCTCAGCCGCTTTTTAGT	0.438													T	54423154	T	T	54423154	3	4	183	1	0	0	0	0	1	0	0	0	3060	652	23	2	659	2	CDC20B	5	54423154	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		54423154	126492106	27	13005											
FAT2	2196	broad.mit.edu	37	chr5	150947475	150947475	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggaataaaaataagggcCgctcccactcctggcctgga	11	12	0	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr5:150947475C>T	uc003lue.3	-	1	1031	c.1018G>A	c.(1018-1020)GGC>AGC	p.G340S	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.G340S	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	340	Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAATAAGGGCCGCTCCCACTC	0.502													T	150947475	T	T	150947475	3	4	183	1	0	0	0	0	1	0	0	0	5690	652	23	2	12123	2	FAT2	5	150947475	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	96524321	150947475	29967785	28	13006											
LARP1	23367	broad.mit.edu	37	chr5	154193504	154193504	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtggtagcaggaggtggcGgcggtgagggcaggaagcgg	23	6	0	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr5:154193504G>A	uc003lvp.2	+	19	3568	c.3139G>A	c.(3139-3141)GGC>AGC	p.G1047S	LARP1_uc003lvo.2_Missense_Mutation_p.G970S	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	1047	Poly-Gly.						protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGGAGGTGGCGGCGGTGAGGG	0.637													A	154193504	A	A	154193504	3	1	183	1	0	0	0	0	1	0	0	0	8628	1116	39	2	2982	2	LARP1	5	154193504	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	3246029	154193504	26721756	29	13007											
EYA4	2070	broad.mit.edu	37	chr6	133844286	133844286	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttaggaggtgctttccccaTtgagaatatttacagtgcaa	9	7	0	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr6:133844286T>C	uc003qec.3	+	18	2167	c.1709T>C	c.(1708-1710)ATT>ACT	p.I570T	EYA4_uc011ecq.1_Missense_Mutation_p.I516T|EYA4_uc011ecr.1_Missense_Mutation_p.I522T|EYA4_uc003qed.3_Missense_Mutation_p.I570T|EYA4_uc003qee.3_Missense_Mutation_p.I547T|EYA4_uc011ecs.1_Missense_Mutation_p.I576T|uc003qeg.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	570					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		GCTTTCCCCATTGAGAATATT	0.383													C	133844286	C	C	133844286	3	2	183	1	0	0	0	0	1	0	0	0	5331	1493	52	4	1775	4	EYA4	6	133844286	Missense_Mutation	SNP	T	TCGA-27-1831-01A-01D-1494-08		133844286	37270781	30	13008											
SDK1	221935	broad.mit.edu	37	chr7	4050700	4050700	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctatcaattccgggtgtgcgCggtgaatgaagtgggcaggg	17	7	1	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:4050700C>T	uc003smx.2	+	15	2373	c.2234C>T	c.(2233-2235)GCG>GTG	p.A745V	SDK1_uc010kso.2_Missense_Mutation_p.A21V	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	745	Fibronectin type-III 1.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CGGGTGTGCGCGGTGAATGAA	0.622													T	4050700	T	T	4050700	3	4	183	1	0	0	0	0	1	0	0	0	13968	768	27	1	2292	1	SDK1	7	4050700	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		4050700	155087963	31	13009											
TMEM196	256130	broad.mit.edu	37	chr7	19765216	19765216	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tctgttcataactggctagtCgacaagtgagccaggaagag	12	8	2	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:19765216C>T	uc011jyg.1	-	3	465	c.380G>A	c.(379-381)CGA>CAA	p.R127Q	TMEM196_uc003sur.2_RNA	NM_152774	NP_689987	Q5HYL7	TM196_HUMAN	transmembrane protein 196	133						integral to membrane					0						ACTGGCTAGTCGACAAGTGAG	0.498													T	19765216	T	T	19765216	3	4	183	1	0	0	0	0	1	0	0	0	16115	884	31	2	146	2	TMEM196	7	19765216	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	15714516	19765216	139373447	32	13010											
EGFR	1956	broad.mit.edu	37	chr7	55211080	55211080	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggaaaacctgcagatcatcaGaggaaatatgtactacgaaa	9	7	2	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:55211080G>A	uc003tqk.2	+	3	569	c.323G>A	c.(322-324)AGA>AAA	p.R108K	EGFR_uc003tqh.2_Missense_Mutation_p.R108K|EGFR_uc003tqi.2_Missense_Mutation_p.R108K|EGFR_uc003tqj.2_Missense_Mutation_p.R108K|EGFR_uc010kzg.1_Missense_Mutation_p.R108K|EGFR_uc011kco.1_Missense_Mutation_p.R55K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	108	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R108K(7)|p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGATCATCAGAGGAAATATG	0.423		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55211080	A	A	55211080	3	1	183	1	0	0	0	0	1	0	0	0	4967	942	33	3	333	3	EGFR	7	55211080	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	35445864	55211080	103927583	33	13011											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	183	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	10742	55221822	103916841	34	13012											
EGFR	1956	broad.mit.edu	37	chr7	55241677	55241677	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctctcttgaggatcttgaagGaaactgaattcaaaaagatc	8	7	3	4			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:55241677G>A	uc003tqk.2	+	18	2371	c.2125G>A	c.(2125-2127)GAA>AAA	p.E709K	EGFR_uc010kzg.1_Missense_Mutation_p.E664K|EGFR_uc011kco.1_Missense_Mutation_p.E656K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	709	Cytoplasmic (Potential).		E -> K (found in a lung cancer sample).|E -> A (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E709K(17)|p.E709A(11)|p.E709G(7)|p.E709V(5)|p.E709_T710>D(5)|p.E709H(2)|p.E709_T710>G(1)|p.E709_T710>A(1)|p.E709fs*1(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATCTTGAAGGAAACTGAATT	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55241677	A	A	55241677	3	1	183	1	0	0	0	0	1	0	0	0	4967	1175	41	3	2459	3	EGFR	7	55241677	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	19855	55241677	103896986	35	13013			1	35		2	2	18	G		4.00874e-05
EGFR	1956	broad.mit.edu	37	chr7	55241694	55241694	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aaggaaactgaattcaaaaaGatcaaagtgctgggctccgg	11	7	2	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:55241694G>C	uc003tqk.2	+	18	2388	c.2142G>C	c.(2140-2142)AAG>AAC	p.K714N	EGFR_uc010kzg.1_Missense_Mutation_p.K669N|EGFR_uc011kco.1_Missense_Mutation_p.K661N	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	714	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AATTCAAAAAGATCAAAGTGC	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			C	55241694	C	C	55241694	3	2	183	1	0	0	0	0	1	0	0	0	4967	933	33	5	2476	5	EGFR	7	55241694	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	17	55241694	103896969	36	13014			1	35		2	2	18	G		4.00874e-05
ZNF3	7551	broad.mit.edu	37	chr7	99669056	99669056	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgatagaggtgtgagctctGgctgaaggctttcccacatt	12	9	1	4			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:99669056G>A	uc003usq.2	-	6	1358	c.1051C>T	c.(1051-1053)CAG>TAG	p.Q351*	ZNF3_uc003usp.2_Intron|ZNF3_uc003usr.2_Nonsense_Mutation_p.Q351*|ZNF3_uc010lgj.2_Nonsense_Mutation_p.Q315*|ZNF3_uc003uss.2_Nonsense_Mutation_p.Q358*|ZNF3_uc003ust.3_Nonsense_Mutation_p.Q351*	NM_032924	NP_116313	P17036	ZNF3_HUMAN	zinc finger protein 3 isoform 2	351	C2H2-type 6.			GEKPYECNECGKAFSQSSHLYQHQRIHTGEKPYECMECGGK FTYSSGLIQHQ -> EALPTFVTLIRLLPSVDPIVTNEAAF PAESLATIFALIWRLFCVHSLMFKKV (in Ref. 2; BAA91019).	cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			TGTGAGCTCTGGCTGAAGGCT	0.473													A	99669056	A	A	99669056	4	1	183	1	0	0	0	0	0	1	0	0	17826	1357	47	3	422	3	ZNF3	7	99669056	Nonsense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	44427362	99669056	59469607	37	13015											
SERPINE1	5054	broad.mit.edu	37	chr7	100779013	100779013	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaccaagagcctctccacGtcgcgcaggcgctgcagaaa	11	15	1	3			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:100779013G>A	uc003uxt.2	+	7	1166	c.1018G>A	c.(1018-1020)GTC>ATC	p.V340I	SERPINE1_uc011kkj.1_Missense_Mutation_p.V325I|SERPINE1_uc003uxu.1_3'UTR	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	340					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	GCCTCTCCACGTCGCGCAGGC	0.582													A	100779013	A	A	100779013	3	1	183	1	0	0	0	0	1	0	0	0	14111	1145	40	1	1040	1	SERPINE1	7	100779013	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	1109957	100779013	58359650	38	13016											
RELN	5649	broad.mit.edu	37	chr7	103205920	103205920	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttgctgaagggcttgctaCagcccatgctcatttcaaac	9	11	2	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:103205920C>T	uc003vca.2	-	34	5175	c.5015G>A	c.(5014-5016)TGT>TAT	p.C1672Y	RELN_uc010liz.2_Missense_Mutation_p.C1672Y	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1672					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGGCTTGCTACAGCCCATGCT	0.448													T	103205920	T	T	103205920	3	4	183	1	0	0	0	0	1	0	0	0	13220	478	17	3	5495	3	RELN	7	103205920	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	2426907	103205920	55932743	39	13017											
NRCAM	4897	broad.mit.edu	37	chr7	107824688	107824688	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	aaggcatcatagctcaccttCcacgtaatcaccaaattatc	4	13	3	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:107824688C>A	uc003vfb.2	-	22	2772	c.2301G>T	c.(2299-2301)TGG>TGT	p.W767C	NRCAM_uc003vfc.2_Missense_Mutation_p.W751C|NRCAM_uc011kmk.1_Missense_Mutation_p.W762C|NRCAM_uc003vfd.2_Missense_Mutation_p.W743C|NRCAM_uc003vfe.2_Missense_Mutation_p.W743C	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	767	Fibronectin type-III 2.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						AGCTCACCTTCCACGTAATCA	0.368													A	107824688	A	A	107824688	3	1	183	1	0	0	0	0	1	0	0	0	10644	856	30	5	1691	5	NRCAM	7	107824688	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	4618768	107824688	51313975	40	13018											
FAM71F1	84691	broad.mit.edu	37	chr7	128355633	128355633	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttgcctgtggatggagagccGaaccctggagcgggcctagg	17	10	0	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:128355633G>A	uc003vno.1	+	1	191	c.138G>A	c.(136-138)CCG>CCA	p.P46P	FAM71F1_uc010llo.1_Intron|FAM71F1_uc011koq.1_Intron|FAM71F1_uc003vnm.1_Intron|FAM71F1_uc003vnn.1_Intron|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Silent_p.P46P	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	46										skin(1)	1						ATGGAGAGCCGAACCCTGGAG	0.522													A	128355633	A	A	128355633	2	1	183	1	0	0	0	0	0	0	0	1	5612	1045	37	2		2	FAM71F1	7	128355633	Silent	SNP	G	TCGA-27-1831-01A-01D-1494-08	20530945	128355633	30783030	41	13019											
UBE3C	9690	broad.mit.edu	37	chr7	157041143	157041143	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttggaaccagtgccgacgtgGacattcaccacctcgcctcc	9	16	1	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr7:157041143G>A	uc010lqs.2	+	19	2875	c.2563G>A	c.(2563-2565)GAC>AAC	p.D855N	UBE3C_uc003wni.3_Missense_Mutation_p.D218N	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	855	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TGCCGACGTGGACATTCACCA	0.502													A	157041143	A	A	157041143	3	1	183	1	0	0	0	0	1	0	0	0	16878	1174	41	3	2637	3	UBE3C	7	157041143	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	28685510	157041143	2097520	42	13020											
UBR5	51366	broad.mit.edu	37	chr8	103289358	103289358	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttccccttcttttttttgCcggttttgcatgttcattac	5	11	3	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr8:103289358C>T	uc003ykr.1	-	45	6384	c.6351G>A	c.(6349-6351)CGG>CGA	p.R2117R	UBR5_uc003yks.1_Silent_p.R2117R	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2117					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTTTTTTTTGCCGGTTTTGCA	0.378													T	103289358	T	T	103289358	2	4	183	1	0	0	0	0	0	0	0	1	16902	726	26	3		3	UBR5	8	103289358	Silent	SNP	C	TCGA-27-1831-01A-01D-1494-08		103289358	43074664	43	13021											
COL14A1	7373	broad.mit.edu	37	chr8	121267573	121267573	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgccatgccacagcctatagGgttgttatagaatccctcca	8	13	0	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr8:121267573G>T	uc003yox.2	+	23	3112	c.2847G>T	c.(2845-2847)AGG>AGT	p.R949S	COL14A1_uc003yoy.2_Missense_Mutation_p.R627S	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	949	Fibronectin type-III 8.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CAGCCTATAGGGTTGTTATAG	0.453													T	121267573	T	T	121267573	3	4	183	1	0	0	0	0	1	0	0	0	3671	1223	43	5	2933	5	COL14A1	8	121267573	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	17978215	121267573	25096449	44	13022											
IFNE	338376	broad.mit.edu	37	chr9	21481272	21481272	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agtacattttaacttgtaatCtaaggttatcactacccaaa	4	8	2	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr9:21481272C>T	uc003zpg.2	-	1	1041	c.422G>A	c.(421-423)AGA>AAA	p.R141K	LOC554202_uc003zpe.2_Intron|LOC554202_uc003zpf.2_Intron	NM_176891	NP_795372	Q86WN2	IFNE_HUMAN	interferon, epsilon precursor	141					defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding				0						AACTTGTAATCTAAGGTTATC	0.433													T	21481272	T	T	21481272	3	4	183	1	0	0	0	0	1	0	0	0	7547	913	32	3	208	3	IFNE	9	21481272	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		21481272	119732159	45	13023											
OIT3	170392	broad.mit.edu	37	chr10	74666378	74666378	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaatgaatgtgagcaaaacaAcggtggctgcagtgagatct	12	6	1	3			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr10:74666378A>G	uc001jte.1	+	4	787	c.569A>G	c.(568-570)AAC>AGC	p.N190S	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	190	EGF-like; calcium-binding (Potential).					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					GAGCAAAACAACGGTGGCTGC	0.488													G	74666378	G	G	74666378	3	3	183	1	0	0	0	0	1	0	0	0	10849	43	2	4	583	4	OIT3	10	74666378	Missense_Mutation	SNP	A	TCGA-27-1831-01A-01D-1494-08		74666378	60868369	46	13024											
EBF3	253738	broad.mit.edu	37	chr10	131640486	131640486	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gggttgttgcccagggtgggGatctggttgtgattgcgggg	21	5	1	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr10:131640486G>C	uc001lki.1	-	13	1298	c.1239C>G	c.(1237-1239)ATC>ATG	p.I413M		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	422					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCAGGGTGGGGATCTGGTTGT	0.617													C	131640486	C	C	131640486	3	2	183	1	0	0	0	0	1	0	0	0	4882	1164	41	5	432	5	EBF3	10	131640486	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	56974108	131640486	3894261	47	13025											
OR52J3	119679	broad.mit.edu	37	chr11	5068212	5068212	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttagcatgtgcattgtaattCgtcccgttttacttacactt	6	9	0	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr11:5068212C>T	uc010qyv.1	+	1	457	c.457C>T	c.(457-459)CGT>TGT	p.R153C		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		CATTGTAATTCGTCCCGTTTT	0.468													T	5068212	T	T	5068212	3	4	183	1	0	0	0	0	1	0	0	0	11122	884	31	2	459	2	OR52J3	11	5068212	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		5068212	129938304	48	13026											
SLC5A12	159963	broad.mit.edu	37	chr11	26718717	26718717	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgctatactaacctcagaGttccactgaaggcacaagcc	8	12	1	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr11:26718717G>A	uc001mra.2	-	8	1347	c.1034C>T	c.(1033-1035)ACT>ATT	p.T345I	SLC5A12_uc001mrb.2_RNA|SLC5A12_uc001mrc.3_Missense_Mutation_p.T345I	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	345	Cytoplasmic (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						TAACCTCAGAGTTCCACTGAA	0.373													A	26718717	A	A	26718717	3	1	183	1	0	0	0	0	1	0	0	0	14664	1029	36	3	854	3	SLC5A12	11	26718717	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	21650505	26718717	108287799	49	13027											
PYGM	5837	broad.mit.edu	37	chr11	64521011	64521011	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggtcttcttgaggatctcGgagtggatgcgcgccacgcc	14	11	3	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr11:64521011G>A	uc001oax.3	-	11	2200	c.1383C>T	c.(1381-1383)TCC>TCT	p.S461S	PYGM_uc001oay.3_Silent_p.S373S	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	461					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	TGAGGATCTCGGAGTGGATGC	0.652													A	64521011	A	A	64521011	2	1	183	1	0	0	0	0	0	0	0	1	12862	1103	39	2		2	PYGM	11	64521011	Silent	SNP	G	TCGA-27-1831-01A-01D-1494-08	37802294	64521011	70485505	50	13028											
GPR83	10888	broad.mit.edu	37	chr11	94113625	94113625	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtagagggcattgttggtgCggatgaccttgctggacagg	17	6	0	2	rs145628763	byFrequency	TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr11:94113625C>T	uc001pet.2	-	4	1134	c.962G>A	c.(961-963)CGC>CAC	p.R321H		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	321	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATTGTTGGTGCGGATGACCTT	0.517													T	94113625	T	T	94113625	3	4	183	1	0	0	0	0	1	0	0	0	6713	768	27	1	313	1	GPR83	11	94113625	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	29592614	94113625	40892891	51	13029											
KIAA1377	57562	broad.mit.edu	37	chr11	101793446	101793446	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcagcaacaaaaaatatgtcGaaatcgagcacgtaaatatt	7	7	0	0	rs142032267		TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr11:101793446G>A	uc001pgm.2	+	2	473	c.203G>A	c.(202-204)CGA>CAA	p.R68Q	KIAA1377_uc001pgn.2_Missense_Mutation_p.R24Q	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	68	Potential.						protein binding	p.R68*(1)		breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AAAATATGTCGAAATCGAGCA	0.303													A	101793446	A	A	101793446	3	1	183	1	0	0	0	0	1	0	0	0	8227	1058	37	2	209	2	KIAA1377	11	101793446	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	7679821	101793446	33213070	52	13030											
GRIN2B	2904	broad.mit.edu	37	chr12	13716353	13716353	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttagtggtggaggcgtttgaCgtcaccgccactggggcagc	16	10	1	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr12:13716353C>T	uc001rbt.2	-	13	3998	c.3819G>A	c.(3817-3819)ACG>ACA	p.T1273T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1273	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGCGTTTGACGTCACCGCCA	0.582													T	13716353	T	T	13716353	2	4	183	1	0	0	0	0	0	0	0	1	6780	523	19	1		1	GRIN2B	12	13716353	Silent	SNP	C	TCGA-27-1831-01A-01D-1494-08		13716353	120135542	53	13031											
EPYC	1833	broad.mit.edu	37	chr12	91363838	91363838	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctggaggtgaagggctcGtagattttctgggagtggca	16	6	1	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr12:91363838G>A	uc001tbk.2	-	6	874	c.781C>T	c.(781-783)CGA>TGA	p.R261*		NM_004950	NP_004941	Q99645	EPYC_HUMAN	dermatan sulfate proteoglycan 3 precursor	261	LRR 5.				female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding			skin(1)	1						TGAAGGGCTCGTAGATTTTCT	0.478													A	91363838	A	A	91363838	4	1	183	1	0	0	0	0	0	1	0	0	5201	1153	40	1	195	1	EPYC	12	91363838	Nonsense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	77647485	91363838	42488057	54	13032											
NR1H4	9971	broad.mit.edu	37	chr12	100897255	100897255	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ggatttttcatggaaatgatGagtatgaagcccgcgaaagg	13	5	1	3			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr12:100897255G>T	uc001tht.1	+	1	118	c.90G>T	c.(88-90)ATG>ATT	p.M30I	NR1H4_uc001thp.1_Intron|NR1H4_uc001thq.1_Intron|NR1H4_uc010svj.1_Intron|NR1H4_uc001thr.1_Intron|NR1H4_uc010svk.1_Intron|NR1H4_uc001ths.1_Missense_Mutation_p.M30I	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	30					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TGGAAATGATGAGTATGAAGC	0.453													T	100897255	T	T	100897255	3	4	183	1	0	0	0	0	1	0	0	0	10619	1305	45	5		5	NR1H4	12	100897255	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	9533417	100897255	32954640	55	13033											
DAO	1610	broad.mit.edu	37	chr12	109293186	109293186	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggtgaacgaactggcttcCggccagtacgcccccagatt	11	13	0	2	rs140015394		TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr12:109293186C>T	uc001tnr.3	+	10	1000	c.847C>T	c.(847-849)CGG>TGG	p.R283W	DAO_uc001tnq.3_Missense_Mutation_p.R217W|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	283		Substrate.			glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2						AACTGGCTTCCGGCCAGTACG	0.458													T	109293186	T	T	109293186	3	4	183	1	0	0	0	0	1	0	0	0	4231	643	23	2	881	2	DAO	12	109293186	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	8395931	109293186	24558709	56	13034											
RPGRIP1	57096	broad.mit.edu	37	chr14	21793505	21793505	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agcccaggtctacctgtcaaCcgatgtgcttggaggccgga	13	12	2	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr14:21793505C>A	uc001wag.2	+	15	2330	c.2330C>A	c.(2329-2331)ACC>AAC	p.T777N	RPGRIP1_uc001wah.2_Missense_Mutation_p.T419N|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001wak.2_Missense_Mutation_p.T252N|RPGRIP1_uc010aim.2_Missense_Mutation_p.T160N|RPGRIP1_uc001wal.2_Missense_Mutation_p.T136N|RPGRIP1_uc001wam.2_Missense_Mutation_p.T94N	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	777					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TACCTGTCAACCGATGTGCTT	0.542													A	21793505	A	A	21793505	3	1	183	1	0	0	0	0	1	0	0	0	13549	507	18	5	2388	5	RPGRIP1	14	21793505	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		21793505	85556035	57	13035											
LOXL1	4016	broad.mit.edu	37	chr15	74238821	74238821	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctactgcgcttcccccagcgCgtgaagaaccagggcacagc	11	16	0	2			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr15:74238821C>T	uc002awc.1	+	3	1611	c.1275C>T	c.(1273-1275)CGC>CGT	p.R425R	LOXL1_uc002awd.1_5'Flank	NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	425	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding				0						TCCCCCAGCGCGTGAAGAACC	0.692													T	74238821	T	T	74238821	2	4	183	1	0	0	0	0	0	0	0	1	8899	755	27	1		1	LOXL1	15	74238821	Silent	SNP	C	TCGA-27-1831-01A-01D-1494-08		74238821	28292571	58	13036											
USP6	9098	broad.mit.edu	37	chr17	5050405	5050405	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaggataaccaaaaagtaCaactctcagtgagcggattt	8	9	2	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr17:5050405C>T	uc002gau.1	+	29	4577	c.2347C>T	c.(2347-2349)CAA>TAA	p.Q783*	USP6_uc002gav.1_Nonsense_Mutation_p.Q783*|USP6_uc010ckz.1_Nonsense_Mutation_p.Q466*	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	783					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						CCAAAAAGTACAACTCTCAGT	0.383			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								T	5050405	T	T	5050405	4	4	183	1	0	0	0	0	0	1	0	0	17083	479	17	3	2425	3	USP6	17	5050405	Nonsense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		5050405	76144805	59	13037											
MYO1D	4642	broad.mit.edu	37	chr17	31105570	31105570	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taatgtacttactggcttccGttttaccagctccactttcc	5	13	0	0			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr17:31105570G>A	uc002hho.1	-	3	338	c.326C>T	c.(325-327)ACG>ATG	p.T109M	MYO1D_uc002hhp.1_Missense_Mutation_p.T109M|MYO1D_uc010wcb.1_Missense_Mutation_p.T109M	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	109	ATP (Potential).|Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			ACTGGCTTCCGTTTTACCAGC	0.393													A	31105570	A	A	31105570	3	1	183	1	0	0	0	0	1	0	0	0	10071	1145	40	1	2774	1	MYO1D	17	31105570	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	26055165	31105570	50089640	60	13038											
MYO19	80179	broad.mit.edu	37	chr17	34856982	34856982	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcctcagccgagtcaccaGttatggctgctgcctgagtt	12	12	2	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr17:34856982G>A	uc010wcy.1	-	23	3166	c.2174C>T	c.(2173-2175)ACT>ATT	p.T725I	MYO19_uc002hmw.2_Missense_Mutation_p.T525I|MYO19_uc010cuu.2_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	725						mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CGAGTCACCAGTTATGGCTGC	0.577													A	34856982	A	A	34856982	3	1	183	1	0	0	0	0	1	0	0	0	10067	1029	36	3	758	3	MYO19	17	34856982	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	3751412	34856982	46338228	61	13039											
TANC2	26115	broad.mit.edu	37	chr17	61428697	61428697	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaccggattatggggatacaAttgtatcgtttctgagtaaa	10	5	1	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr17:61428697A>G	uc002jal.3	+	11	1695	c.1672A>G	c.(1672-1674)ATT>GTT	p.I558V	TANC2_uc010wpe.1_Missense_Mutation_p.I468V	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	558							binding			ovary(2)	2						TGGGGATACAATTGTATCGTT	0.338													G	61428697	G	G	61428697	3	3	183	1	0	0	0	0	1	0	0	0	15542	101	4	4	1714	4	TANC2	17	61428697	Missense_Mutation	SNP	A	TCGA-27-1831-01A-01D-1494-08	26571715	61428697	19766513	62	13040											
PTPRM	5797	broad.mit.edu	37	chr18	7888125	7888125	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttctttcatgctggtgaatgCctctgggagacctgaggggc	14	9	3	3			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr18:7888125C>A	uc002knn.3	+	3	721	c.218C>A	c.(217-219)GCC>GAC	p.A73D	PTPRM_uc010dkv.2_Missense_Mutation_p.A73D	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	73	MAM.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CTGGTGAATGCCTCTGGGAGA	0.453													A	7888125	A	A	7888125	3	1	183	1	0	0	0	0	1	0	0	0	12806	739	26	5	228	5	PTPRM	18	7888125	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		7888125	70189123	63	13041											
MUC16	94025	broad.mit.edu	37	chr19	9087832	9087832	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacttgtatccttaggatccGtagtggtgatgtaggtggtg	14	5	0	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr19:9087832G>A	uc002mkp.2	-	1	4187	c.3983C>T	c.(3982-3984)ACG>ATG	p.T1328M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1328	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTTAGGATCCGTAGTGGTGAT	0.527													A	9087832	A	A	9087832	3	1	183	1	0	0	0	0	1	0	0	0	9973	1145	40	1	39876	1	MUC16	19	9087832	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08		9087832	50041151	64	13042											
RAB3D	9545	broad.mit.edu	37	chr19	11448018	11448018	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tagcagtttgaacatatagtCgaagttctgatctgctgcat	9	7	2	2	rs144965675	by1000genomes	TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr19:11448018C>T	uc002mqy.2	-	2	296	c.58G>A	c.(58-60)GAC>AAC	p.D20N		NM_004283	NP_004274	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	20					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(2)	2						AACATATAGTCGAAGTTCTGA	0.557													T	11448018	T	T	11448018	3	4	183	1	0	0	0	0	1	0	0	0	12934	884	31	2	617	2	RAB3D	19	11448018	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	2360186	11448018	47680965	65	13043											
OR10H2	26538	broad.mit.edu	37	chr19	15839588	15839589	+	Frame_Shift_Ins	INS	-	CTTATTGTGG	CTTATTGTGG													tctccacctgtgcctctcacINScttattgtggtcattgtgca							TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr19:15839588_15839589insCTTATTGTGG	uc002nbm.2	+	1	755_756	c.735_736insCTTATTGTGG	c.(733-738)CACCTTfs	p.H245fs		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	245_246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GTGCCTCTCACCTTATTGTGGT	0.54													CTTATTGTGG	15839589	CTTATTGTGG	CTTATTGTGG	15839588	7	5	183	1	0	1	1	0	0	0	0	0	10906	506	18	0	737	0	OR10H2	19	15839588	Frame_Shift_Ins	INS	-	TCGA-27-1831-01A-01D-1494-08	4391570	15839588	43289395	66	13044											
ZNF91	7644	broad.mit.edu	37	chr19	23543307	23543307	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cacattctttacatttgtagGgtttctctccagtatgaatt	6	8	2	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr19:23543307G>C	uc002nre.2	-	4	2587	c.2474C>G	c.(2473-2475)CCC>CGC	p.P825R	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.P793R	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	825						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				ACATTTGTAGGGTTTCTCTCC	0.403													C	23543307	C	C	23543307	3	2	183	1	0	0	0	0	1	0	0	0	18197	1232	43	5	1105	5	ZNF91	19	23543307	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	7703719	23543307	35585676	67	13045											
C5AR1	728	broad.mit.edu	37	chr19	47823716	47823716	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttacactttcatcctgctcCggacgtggagccgcagggcc	12	14	1	0	rs146163744		TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr19:47823716C>T	uc002pgj.1	+	2	731	c.682C>T	c.(682-684)CGG>TGG	p.R228W		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	228	Cytoplasmic (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CATCCTGCTCCGGACGTGGAG	0.612													T	47823716	T	T	47823716	3	4	183	1	0	0	0	0	1	0	0	0	2281	643	23	2	687	2	C5AR1	19	47823716	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08	24280409	47823716	11305267	68	13046											
SSTR4	6754	broad.mit.edu	37	chr20	23016973	23016973	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagctgctgaacctcttcGtgaccagccttgatgccacc	9	15	1	3			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr20:23016973G>A	uc002wsr.2	+	1	917	c.853G>A	c.(853-855)GTG>ATG	p.V285M		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	285	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GAACCTCTTCGTGACCAGCCT	0.552													A	23016973	A	A	23016973	3	1	183	1	0	0	0	0	1	0	0	0	15199	1145	40	1	855	1	SSTR4	20	23016973	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08		23016973	40008547	69	13047											
CLDN14	23562	broad.mit.edu	37	chr21	37833888	37833888	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtgaggatgttggtgcccaCgtgcgctgtcctccgccagt	14	13	0	1	rs142205038		TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chr21:37833888C>T	uc002yvk.1	-	2	248	c.106G>A	c.(106-108)GTG>ATG	p.V36M	CLDN14_uc002yvn.1_Missense_Mutation_p.V36M|CLDN14_uc002yvo.1_Missense_Mutation_p.V36M|CLDN14_uc002yvl.1_Missense_Mutation_p.V36M|CLDN14_uc002yvm.1_Missense_Mutation_p.V36M	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	36	Extracellular (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TTGGTGCCCACGTGCGCTGTC	0.622													T	37833888	T	T	37833888	3	4	183	1	0	0	0	0	1	0	0	0	3475	536	19	1	617	1	CLDN14	21	37833888	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		37833888	10296007	70	13048											
IL3RA	3563	broad.mit.edu	37	chrX	1484071	1484071	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagctactcaatcctggaaCgtacacagtacaaataagag	7	11	1	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chrX:1484071C>T	uc004cps.2	+	9	1149	c.800C>T	c.(799-801)ACG>ATG	p.T267M	IL3RA_uc011mhd.1_Missense_Mutation_p.T189M	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	267	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AATCCTGGAACGTACACAGTA	0.433													T	1484071	T	T	1484071	3	4	183	1	0	0	0	0	1	0	0	0	7695	536	19	1	830	1	IL3RA	23	1484071	Missense_Mutation	SNP	C	TCGA-27-1831-01A-01D-1494-08		1484071	153786489	71	13049											
STS	412	broad.mit.edu	37	chrX	7177573	7177573	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctccccctgcagatcgtcgGggtcaccctccttacccttg	8	19	1	1			TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chrX:7177573G>A	uc004cry.3	+	5	826	c.581G>A	c.(580-582)GGG>GAG	p.G194E		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	194	Helical.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CAGATCGTCGGGGTCACCCTC	0.567									Ichthyosis				A	7177573	A	A	7177573	3	1	183	1	0	0	0	0	1	0	0	0	15331	1232	43	3	599	3	STS	23	7177573	Missense_Mutation	SNP	G	TCGA-27-1831-01A-01D-1494-08	5693502	7177573	148092987	72	13050											
SATL1	340562	broad.mit.edu	37	chrX	84349151	84349151	+	Frame_Shift_Del	DEL	A	-	-													taccttggtaagcttgtgtgAcataaaagtcctctaggtaa							TCGA-27-1831-01A-01D-1494-08	TCGA-27-1831-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9880c3c9-5685-42a7-8fe9-7585ea1a1d37	638e5204-4a1a-43a0-bab5-2d3f1bac8dee	g.chrX:84349151delA	uc011mqx.1	-	4	1859	c.1859delT	c.(1858-1860)GTCfs	p.V620fs	SATL1_uc004een.2_Frame_Shift_Del_p.V620fs	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	433	N-acetyltransferase.|Acetyl-CoA binding (By similarity).						N-acetyltransferase activity			breast(2)	2						AGCTTGTGTGACATAAAAGTC	0.338													-	84349151	-	-	84349151	7	5	183	1	0	1	0	1	0	0	0	0	13855	275	10	0	47	0	SATL1	23	84349151	Frame_Shift_Del	DEL	A	TCGA-27-1831-01A-01D-1494-08	77171578	84349151	70921409	73	13051											
RPE65	6121	broad.mit.edu	37	chr1	68904666	68904666	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acaatcagaaacccattgtcTtcataggtgttgatgtgatg	9	7	3	3			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr1:68904666T>A	uc001dei.1	-	9	1011	c.957A>T	c.(955-957)GAA>GAT	p.E319D		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	319					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						ACCCATTGTCTTCATAGGTGT	0.413													A	68904666	A	A	68904666	3	1	184	1	0	0	0	0	1	0	0	0	13545	1606	56	5	668	5	RPE65	1	68904666	Missense_Mutation	SNP	T	TCGA-27-1832-01A-01W-0643-08		68904666	180345955	1	13052											
SLC39A1	27173	broad.mit.edu	37	chr1	153933124	153933124	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcagagcccttgtttcctccAgaggtgacggccctgactgc	12	14	0	4			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr1:153933124A>G	uc001fdh.2	-	4	594	c.425T>C	c.(424-426)CTG>CCG	p.L142P	CRTC2_uc010ped.1_5'Flank|SLC39A1_uc001fdi.2_Missense_Mutation_p.L142P|SLC39A1_uc001fdj.2_Missense_Mutation_p.L142P|SLC39A1_uc001fdk.2_Missense_Mutation_p.L142P|SLC39A1_uc010pee.1_Missense_Mutation_p.L40P|SLC39A1_uc001fdl.2_Missense_Mutation_p.L142P	NM_014437	NP_055252	Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter),	142	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		TGTTTCCTCCAGAGGTGACGG	0.607													G	153933124	G	G	153933124	3	3	184	1	0	0	0	0	1	0	0	0	14612	188	7	4	553	4	SLC39A1	1	153933124	Missense_Mutation	SNP	A	TCGA-27-1832-01A-01W-0643-08	85028458	153933124	95317497	2	13053											
NRXN1	9378	broad.mit.edu	37	chr2	50847197	50847197	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	taaagttgttactgactggtGaccctggaaggtcggctgtg	14	7	0	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr2:50847197G>A	uc010fbq.2	-	8	2880	c.1403C>T	c.(1402-1404)TCA>TTA	p.S468L	NRXN1_uc002rxb.3_Missense_Mutation_p.S100L|NRXN1_uc002rxe.3_Missense_Mutation_p.S428L|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACTGACTGGTGACCCTGGAAG	0.463													A	50847197	A	A	50847197	3	1	184	1	0	0	0	0	1	0	0	0	10665	1294	45	3	3567	3	NRXN1	2	50847197	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08		50847197	192352176	3	13054											
EIF2AK3	9451	broad.mit.edu	37	chr2	88870441	88870441	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacttgtcctgtgtgtctgGcataagctggcattggggtc	13	9	1	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr2:88870441G>A	uc002stc.3	-	14	3138	c.2936C>T	c.(2935-2937)GCC>GTC	p.A979V		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	979	Cytoplasmic (Potential).|Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						TGTGTGTCTGGCATAAGCTGG	0.488													A	88870441	A	A	88870441	3	1	184	1	0	0	0	0	1	0	0	0	4998	1203	42	3	430	3	EIF2AK3	2	88870441	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08	38023244	88870441	154328932	4	13055											
COL5A2	1290	broad.mit.edu	37	chr2	189918184	189918184	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaccaacagctccagttggcCcattttcacctcgagaaccc	6	16	1	1			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr2:189918184C>T	uc002uqk.2	-	38	2794	c.2519G>A	c.(2518-2520)GGG>GAG	p.G840E	COL5A2_uc010frx.2_Missense_Mutation_p.G416E	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	840					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCCAGTTGGCCCATTTTCACC	0.343													T	189918184	T	T	189918184	3	4	184	1	0	0	0	0	1	0	0	0	3697	623	22	3	2048	3	COL5A2	2	189918184	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08	101047743	189918184	53281189	5	13056											
GLS	2744	broad.mit.edu	37	chr2	191769831	191769831	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcttggaactgaatatgtgcAtcgatatgttggaaaagagc	11	5	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr2:191769831A>T	uc002usf.2	+	6	1181	c.917A>T	c.(916-918)CAT>CTT	p.H306L	GLS_uc002use.2_Missense_Mutation_p.H306L	NM_014905	NP_055720	O94925	GLSK_HUMAN	glutaminase precursor	306					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAATATGTGCATCGATATGTT	0.348													T	191769831	T	T	191769831	3	4	184	1	0	0	0	0	1	0	0	0	6463	217	8	5	939	5	GLS	2	191769831	Missense_Mutation	SNP	A	TCGA-27-1832-01A-01W-0643-08	1851647	191769831	51429542	6	13057											
CPS1	1373	broad.mit.edu	37	chr2	211441119	211441119	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaaaggacagattctcacaAtggccaaccctattattggg	8	10	1	1			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr2:211441119A>G	uc002vee.3	+	3	418	c.286A>G	c.(286-288)ATG>GTG	p.M96V	CPS1_uc010fur.2_Missense_Mutation_p.M102V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	96	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GATTCTCACAATGGCCAACCC	0.408													G	211441119	G	G	211441119	3	3	184	1	0	0	0	0	1	0	0	0	3823	101	4	4	318	4	CPS1	2	211441119	Missense_Mutation	SNP	A	TCGA-27-1832-01A-01W-0643-08	19671288	211441119	31758254	7	13058											
KIF9	64147	broad.mit.edu	37	chr3	47307239	47307239	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctaacgagtccttcagagcGtgggtgagcttgcactgccg	13	12	1	2	rs146278510		TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr3:47307239G>A	uc010hjp.2	-	9	1501	c.897C>T	c.(895-897)CAC>CAT	p.H299H	KIF9_uc003cqx.2_Silent_p.H299H|KIF9_uc003cqy.2_Silent_p.H299H|KIF9_uc011bat.1_RNA|KIF9_uc011bau.1_RNA	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	299					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CCTTCAGAGCGTGGGTGAGCT	0.582													A	47307239	A	A	47307239	2	1	184	1	0	0	0	0	0	0	0	1	8310	1136	40	1		1	KIF9	3	47307239	Silent	SNP	G	TCGA-27-1832-01A-01W-0643-08		47307239	150715191	8	13059											
CEP135	9662	broad.mit.edu	37	chr4	56875926	56875926	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgaaagaaacattggttaatCgagatcgtgagataaacagc	10	5	0	4			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr4:56875926C>T	uc003hbi.2	+	19	2596	c.2362C>T	c.(2362-2364)CGA>TGA	p.R788*	CEP135_uc003hbj.2_Nonsense_Mutation_p.R494*	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	788	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					ATTGGTTAATCGAGATCGTGA	0.363													T	56875926	T	T	56875926	4	4	184	1	0	0	0	0	0	1	0	0	3247	876	31	2	2432	2	CEP135	4	56875926	Nonsense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08		56875926	134278350	9	13060											
WDFY3	23001	broad.mit.edu	37	chr4	85657415	85657415	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accaaagccactgctgacacGggataatttggactgtgtgg	12	9	0	1			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr4:85657415G>A	uc003hpd.2	-	42	7231	c.6823C>T	c.(6823-6825)CGT>TGT	p.R2275C	WDFY3_uc003hpe.1_5'Flank	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2275						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CTGCTGACACGGGATAATTTG	0.373													A	85657415	A	A	85657415	3	1	184	1	0	0	0	0	1	0	0	0	17267	1116	39	2	3865	2	WDFY3	4	85657415	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08	28781489	85657415	105496861	10	13061											
GFM2	84340	broad.mit.edu	37	chr5	74056813	74056813	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttatagcagcatatattcTagtaaagagaaaaagaaact	6	4	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr5:74056813T>C	uc003kdh.1	-	3	368	c.64_splice	c.e3-1	p.N22_splice	GFM2_uc003kdi.1_Splice_Site_p.N22_splice|GFM2_uc010izj.1_Splice_Site_p.N54_splice|GFM2_uc010izk.1_Splice_Site|GFM2_uc003kdj.1_Splice_Site_p.N22_splice|GFM2_uc010izl.1_Splice_Site_p.N22_splice	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1						mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		GCATATATTCTAGTAAAGAGA	0.294													C	74056813	C	C	74056813	5	2	184	1	0	0	0	0	0	0	1	0	6342	1536	53	4	2385	4	GFM2	5	74056813	Splice_Site	SNP	T	TCGA-27-1832-01A-01W-0643-08		74056813	106858447	11	13062											
PCDHA1	56147	broad.mit.edu	37	chr5	140167207	140167207	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acggccagggtgtccgtggaGgtggccgacgtgaatgacaa	17	9	0	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr5:140167207G>A	uc003lhb.2	+	1	1332	c.1332G>A	c.(1330-1332)GAG>GAA	p.E444E	PCDHA1_uc003lha.2_Silent_p.E444E|PCDHA1_uc003lgz.2_Silent_p.E444E	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	444	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCCGTGGAGGTGGCCGACG	0.667													A	140167207	A	A	140167207	2	1	184	1	0	0	0	0	0	0	0	1	11519	991	35	3		3	PCDHA1	5	140167207	Silent	SNP	G	TCGA-27-1832-01A-01W-0643-08	66110394	140167207	40748053	12	13063											
RP9	6100	broad.mit.edu	37	chr7	33138995	33138995	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagccagaaattccctggcGtgttcattgcctggtacatc	10	11	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr7:33138995G>A	uc003tdm.2	-	3	255	c.237C>T	c.(235-237)CAC>CAT	p.H79H		NM_203288	NP_976033	Q8TA86	RP9_HUMAN	retinitis pigmentosa 9	79	PIM1-binding (By similarity).				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding				0			GBM - Glioblastoma multiforme(11;0.0403)			ATTCCCTGGCGTGTTCATTGC	0.463													A	33138995	A	A	33138995	2	1	184	1	0	0	0	0	0	0	0	1	13535	1136	40	1		1	RP9	7	33138995	Silent	SNP	G	TCGA-27-1832-01A-01W-0643-08		33138995	125999668	13	13064											
CCDC146	57639	broad.mit.edu	37	chr7	76796979	76796979	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attaattttattttagaatcGtgaaaaatggaagacagtag	8	2	0	3			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr7:76796979G>A	uc003uga.2	+	2	121	c.-6G>A	c.(-8--4)TCGTG>TCATG		CCDC146_uc003ufz.1_Translation_Start_Site	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146											ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				TTTTAGAATCGTGAAAAATGG	0.308													A	76796979	A	A	76796979	1	1	184	1	0	0	0	0	0	0	0	0	2780	1160	40	1		1	CCDC146	7	76796979	Translation_Start_Site	SNP	G	TCGA-27-1832-01A-01W-0643-08	43657984	76796979	82341684	14	13065											
CROT	54677	broad.mit.edu	37	chr7	86998729	86998729	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccaaaccacattgtagtgctGtgtcgaggccgagcttttgt	11	10	0	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr7:86998729G>T	uc003uit.2	+	7	830	c.585G>T	c.(583-585)CTG>CTT	p.L195L	CROT_uc003uiu.2_Silent_p.L223L	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	195					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TTGTAGTGCTGTGTCGAGGCC	0.428													T	86998729	T	T	86998729	2	4	184	1	0	0	0	0	0	0	0	1	3894	1364	48	5		5	CROT	7	86998729	Silent	SNP	G	TCGA-27-1832-01A-01W-0643-08	10201750	86998729	72139934	15	13066											
ATP6V0A4	50617	broad.mit.edu	37	chr7	138440516	138440516	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctctgggcaagggtagacaGtggctcgaaacctgtgttta	14	8	1	1			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr7:138440516G>T	uc003vuf.2	-	9	972	c.734C>A	c.(733-735)ACT>AAT	p.T245N	ATP6V0A4_uc003vug.2_Missense_Mutation_p.T245N|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.T245N	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	245	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						AGGGTAGACAGTGGCTCGAAA	0.498													T	138440516	T	T	138440516	3	4	184	1	0	0	0	0	1	0	0	0	1170	1029	36	5	1840	5	ATP6V0A4	7	138440516	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08	51441787	138440516	20698147	16	13067											
C9orf131	138724	broad.mit.edu	37	chr9	35045866	35045866	+	Nonstop_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cccaccaaatctagtcagtaGagaaaaggctggtaatacta	8	9	2	1			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr9:35045866G>C	uc003zvw.2	+	2	3269	c.3240G>C	c.(3238-3240)TAG>TAC	p.*1080Y	C9orf131_uc003zvu.2_Nonstop_Mutation_p.*1032Y|C9orf131_uc003zvv.2_Nonstop_Mutation_p.*1007Y|C9orf131_uc003zvx.2_Nonstop_Mutation_p.*1045Y	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	1080											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CTAGTCAGTAGAGAAAAGGCT	0.483													C	35045866	C	C	35045866	4	2	184	1	0	0	0	0	0	0	0	0	2457	937	33	5	3262	5	C9orf131	9	35045866	Nonstop_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08		35045866	106167565	17	13068											
CNTNAP3	79937	broad.mit.edu	37	chr9	39099958	39099959	+	Frame_Shift_Ins	INS	-	C	C													gaaggcacagtcacaggtgaINScccccctgcgtttctctctg							TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr9:39099958_39099959insC	uc004abi.2	-	18	3183_3184	c.2944_2945insG	c.(2944-2946)GTCfs	p.V982fs	CNTNAP3_uc004abj.2_Intron|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Frame_Shift_Ins_p.V982fs	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	982	EGF-like 2.|Extracellular (Potential).				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GTCACAGGTGACCCCCCTGCGT	0.535													C	39099959	C	C	39099958	7	5	184	1	0	1	1	0	0	0	0	0	3648	275	10	0	949	0	CNTNAP3	9	39099958	Frame_Shift_Ins	INS	-	TCGA-27-1832-01A-01W-0643-08	4054092	39099958	102113473	18	13069											
GPR107	57720	broad.mit.edu	37	chr9	132848732	132848732	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatccttttctgttcataatAatggtggggcagtgtcattt	9	6	3	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr9:132848732A>G	uc004bze.2	+	7	825	c.598A>G	c.(598-600)AAT>GAT	p.N200D	GPR107_uc004bzb.2_Missense_Mutation_p.N11D|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.N200D|GPR107_uc004bzd.2_Missense_Mutation_p.N200D	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	200						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				TGTTCATAATAATGGTGGGGC	0.348													G	132848732	G	G	132848732	3	3	184	1	0	0	0	0	1	0	0	0	6623	362	13	4	624	4	GPR107	9	132848732	Missense_Mutation	SNP	A	TCGA-27-1832-01A-01W-0643-08	93748774	132848732	8364699	19	13070											
MS4A6A	64231	broad.mit.edu	37	chr11	59947358	59947358	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacagtgtagaagtcacttgGgtaaaatttggagagaagga	13	3	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr11:59947358G>A	uc001nor.2	-	3	466	c.228C>T	c.(226-228)ACC>ACT	p.T76T	MS4A6A_uc001noq.2_Silent_p.T76T|MS4A6A_uc001nos.3_Silent_p.T104T|MS4A6A_uc009ymv.2_Silent_p.T76T|MS4A6A_uc001not.2_Silent_p.T76T|MS4A6A_uc010rla.1_Silent_p.T104T|MS4A6A_uc010rlb.1_Intron	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	76	Extracellular (Potential).					integral to membrane	receptor activity				0						AAGTCACTTGGGTAAAATTTG	0.468													A	59947358	A	A	59947358	2	1	184	1	0	0	0	0	0	0	0	1	9864	1219	43	3		3	MS4A6A	11	59947358	Silent	SNP	G	TCGA-27-1832-01A-01W-0643-08		59947358	75059158	20	13071											
USP28	57646	broad.mit.edu	37	chr11	113688486	113688486	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttctgaggcaggttttgtacTagcaaattcaataacatatt	7	6	2	1			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr11:113688486T>C	uc001poh.2	-	13	1390	c.1357A>G	c.(1357-1359)AGT>GGT	p.S453G	USP28_uc001pog.2_Missense_Mutation_p.S161G|USP28_uc010rwy.1_Missense_Mutation_p.S328G|USP28_uc001poi.2_Intron|USP28_uc001poj.3_Missense_Mutation_p.S453G	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	453					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		GGTTTTGTACTAGCAAATTCA	0.463													C	113688486	C	C	113688486	3	2	184	1	0	0	0	0	1	0	0	0	17055	1522	53	4	1928	4	USP28	11	113688486	Missense_Mutation	SNP	T	TCGA-27-1832-01A-01W-0643-08	53741128	113688486	21318030	21	13072											
CD163L1	283316	broad.mit.edu	37	chr12	7559406	7559406	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctctactctccccatacagCggttagttccacctacaagc	6	16	2	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr12:7559406C>T	uc001qsy.2	-	5	835	c.809G>A	c.(808-810)CGC>CAC	p.R270H	CD163L1_uc010sge.1_Missense_Mutation_p.R280H	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	270	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CCCCATACAGCGGTTAGTTCC	0.448													T	7559406	T	T	7559406	3	4	184	1	0	0	0	0	1	0	0	0	2968	768	27	1	3612	1	CD163L1	12	7559406	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08		7559406	126292489	22	13073											
TRPV4	59341	broad.mit.edu	37	chr12	110236625	110236625	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgcctcgcgagtcctggcGccgcatgtccgccttcttgt	12	15	1	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr12:110236625G>A	uc001tpj.1	-	5	1041	c.946C>T	c.(946-948)CGC>TGC	p.R316C	TRPV4_uc001tpg.1_Missense_Mutation_p.R282C|TRPV4_uc001tph.1_Missense_Mutation_p.R269C|TRPV4_uc001tpi.1_Missense_Mutation_p.R269C|TRPV4_uc001tpk.1_Missense_Mutation_p.R316C|TRPV4_uc001tpl.1_Missense_Mutation_p.R316C	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	316	Cytoplasmic (Potential).		R -> C (in CMT2C and SPSMA).		actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GAGTCCTGGCGCCGCATGTCC	0.612													A	110236625	A	A	110236625	3	1	184	1	0	0	0	0	1	0	0	0	16595	1087	38	1	1713	1	TRPV4	12	110236625	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08	102677219	110236625	23615270	23	13074											
AACS	65985	broad.mit.edu	37	chr12	125599073	125599073	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgcacggcaacatgacCagcagtgacatcctcctgtg	10	14	0	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr12:125599073C>A	uc001uhc.2	+	9	1172	c.966C>A	c.(964-966)ACC>ACA	p.T322T	AACS_uc001uhd.2_Silent_p.T322T|AACS_uc009zyh.2_RNA|AACS_uc009zyi.2_5'UTR	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	322					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		GCAACATGACCAGCAGTGACA	0.607													A	125599073	A	A	125599073	2	1	184	1	0	0	0	0	0	0	0	1	9	581	21	5		5	AACS	12	125599073	Silent	SNP	C	TCGA-27-1832-01A-01W-0643-08	15362448	125599073	8252822	24	13075											
IPO5	3843	broad.mit.edu	37	chr13	98666352	98666352	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctggagtgtgcaagagtcCgtggtcctgagtatctcaca	12	10	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr13:98666352C>T	uc001vne.2	+	22	2443	c.2263C>T	c.(2263-2265)CGT>TGT	p.R755C		NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	737					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						TGCAAGAGTCCGTGGTCCTGA	0.438													T	98666352	T	T	98666352	3	4	184	1	0	0	0	0	1	0	0	0	7796	652	23	2	2341	2	IPO5	13	98666352	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08		98666352	16503526	25	13076											
F10	2159	broad.mit.edu	37	chr13	113793675	113793675	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatcctctctttgcagatggCgaccagtgtgagaccagtcc	10	12	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr13:113793675C>T	uc001vsx.2	+	4	318	c.261C>T	c.(259-261)GGC>GGT	p.G87G	F10_uc010agq.1_RNA|F10_uc001vsy.2_Silent_p.G87G|F10_uc001vsz.2_Silent_p.G87G	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	87	EGF-like 1; calcium-binding (Potential).				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGCAGATGGCGACCAGTGTG	0.502													T	113793675	T	T	113793675	2	4	184	1	0	0	0	0	0	0	0	1	5336	755	27	1		1	F10	13	113793675	Silent	SNP	C	TCGA-27-1832-01A-01W-0643-08	15127323	113793675	1376203	26	13077											
SLC7A7	9056	broad.mit.edu	37	chr14	23245049	23245049	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgccactcttacctagaagCagccacaatggaggcattga	9	11	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr14:23245049C>T	uc001wgr.3	-	6	1129	c.991G>A	c.(991-993)GCT>ACT	p.A331T	SLC7A7_uc001wgs.3_Missense_Mutation_p.A331T|SLC7A7_uc001wgt.3_Missense_Mutation_p.A331T|SLC7A7_uc001wgu.3_Missense_Mutation_p.A331T|SLC7A7_uc001wgv.3_Missense_Mutation_p.A331T	NM_003982	NP_003973	Q9UM01	YLAT1_HUMAN	solute carrier family 7 member 7	331					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			ovary(1)|breast(1)	2	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		TACCTAGAAGCAGCCACAATG	0.428													T	23245049	T	T	23245049	3	4	184	1	0	0	0	0	1	0	0	0	14703	710	25	3	564	3	SLC7A7	14	23245049	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08		23245049	84104491	27	13078											
NFKBIA	4792	broad.mit.edu	37	chr14	35871759	35871759	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agctggtagggagaatagccCtggtaggtaactctgttgac	14	7	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr14:35871759C>A	uc001wtf.3	-	5	857	c.747G>T	c.(745-747)CAG>CAT	p.Q249H	NFKBIA_uc001wte.3_Missense_Mutation_p.Q159H|NFKBIA_uc001wtg.3_Intron|NFKBIA_uc010amo.2_RNA	NM_020529	NP_065390	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene	249					anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(2)	2	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		GAGAATAGCCCTGGTAGGTAA	0.577													A	35871759	A	A	35871759	3	1	184	1	0	0	0	0	1	0	0	0	10377	680	24	5	214	5	NFKBIA	14	35871759	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08	12626710	35871759	71477781	28	13079											
TPSD1	23430	broad.mit.edu	37	chr16	1306641	1306641	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgcacttctgcgggggctcCctcatccacccccagtgggt	11	16	2	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr16:1306641C>T	uc002clb.1	+	2	216	c.207C>T	c.(205-207)TCC>TCT	p.S69S	TPSD1_uc010brm.1_Silent_p.S7S	NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	69	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GCGGGGGCTCCCTCATCCACC	0.692													T	1306641	T	T	1306641	2	4	184	1	0	0	0	0	0	0	0	1	16422	610	22	3		3	TPSD1	16	1306641	Silent	SNP	C	TCGA-27-1832-01A-01W-0643-08		1306641	89048112	29	13080											
DNAH3	55567	broad.mit.edu	37	chr16	20975342	20975342	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtagcccatccgagtctcGtcaatctgcgtttctgtcat	8	12	5	0	rs142743875	byFrequency	TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr16:20975342G>A	uc010vbe.1	-	53	9864	c.9864C>T	c.(9862-9864)GAC>GAT	p.D3288D	DNAH3_uc010vbd.1_Silent_p.D723D	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3288					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCCGAGTCTCGTCAATCTGCG	0.498													A	20975342	A	A	20975342	2	1	184	1	0	0	0	0	0	0	0	1	4603	1136	40	1		1	DNAH3	16	20975342	Silent	SNP	G	TCGA-27-1832-01A-01W-0643-08	19668701	20975342	69379411	30	13081											
KIAA0556	23247	broad.mit.edu	37	chr16	27761189	27761189	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggtgactttaaaatccccGtcttgccttatggacagcgc	11	11	1	1			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr16:27761189G>A	uc002dow.2	+	16	2932	c.2908G>A	c.(2908-2910)GTC>ATC	p.V970I		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	970										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TAAAATCCCCGTCTTGCCTTA	0.557													A	27761189	A	A	27761189	3	1	184	1	0	0	0	0	1	0	0	0	8183	1145	40	1	2970	1	KIAA0556	16	27761189	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08	6785847	27761189	62593564	31	13082											
TRIM72	493829	broad.mit.edu	37	chr16	31235634	31235634	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgcgccagttcgacaaggCggtggcggtggtggcgcacc	17	14	0	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr16:31235634C>T	uc002ebn.1	+	7	1221	c.992C>T	c.(991-993)GCG>GTG	p.A331V	uc002ebp.1_5'Flank	NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	331	B30.2/SPRY.				exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						TTCGACAAGGCGGTGGCGGTG	0.697													T	31235634	T	T	31235634	3	4	184	1	0	0	0	0	1	0	0	0	16542	768	27	1	1014	1	TRIM72	16	31235634	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08	3474445	31235634	59119119	32	13083											
SMCR8	140775	broad.mit.edu	37	chr17	18219935	18219935	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagcacatccaggatcagGccagccaggcatccactacc	10	15	1	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr17:18219935G>A	uc002gsy.3	+	1	1342	c.832G>A	c.(832-834)GCC>ACC	p.A278T		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	278										central_nervous_system(1)	1						CCAGGATCAGGCCAGCCAGGC	0.517													A	18219935	A	A	18219935	3	1	184	1	0	0	0	0	1	0	0	0	14792	1203	42	3	834	3	SMCR8	17	18219935	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08		18219935	62975275	33	13084											
ENPP7	339221	broad.mit.edu	37	chr17	77710991	77710991	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtgtacgagctcatgtgccGgctgctgggcatcgtgcccg	15	13	1	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr17:77710991G>A	uc002jxa.2	+	4	1198	c.1178G>A	c.(1177-1179)CGG>CAG	p.R393Q		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	393					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CTCATGTGCCGGCTGCTGGGC	0.647													A	77710991	A	A	77710991	3	1	184	1	0	0	0	0	1	0	0	0	5135	1116	39	2	1192	2	ENPP7	17	77710991	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08	59491056	77710991	3484219	34	13085											
SLC38A10	124565	broad.mit.edu	37	chr17	79226299	79226302	+	Frame_Shift_Del	DEL	TCTT	-	-													tgctccggctcttgtttctcTctttctgagtcgggcagagg							TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr17:79226299_79226302delTCTT	uc002jzz.1	-	13	2013_2016	c.1638_1641delAAGA	c.(1636-1641)GAAAGAfs	p.E546fs	SLC38A10_uc002jzy.1_Frame_Shift_Del_p.E464fs|SLC38A10_uc002kab.2_Frame_Shift_Del_p.E546fs	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	546_547					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CTTGTTTCTCTCTTTCTGAGTCGG	0.618													-	79226302	-	-	79226299	7	5	184	1	0	1	0	1	0	0	0	0	14602	1548	54	0	2012	0	SLC38A10	17	79226299	Frame_Shift_Del	DEL	TCTT	TCGA-27-1832-01A-01W-0643-08	1515308	79226299	1968911	35	13086											
DUS1L	64118	broad.mit.edu	37	chr17	80020801	80020801	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcaatctccgggaagacaCggattttgcacgtgacagga	12	9	2	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr17:80020801C>T	uc002kdq.2	-	4	865	c.446G>A	c.(445-447)CGT>CAT	p.R149H	DUS1L_uc002kdp.2_Missense_Mutation_p.R18H|DUS1L_uc002kdr.2_Missense_Mutation_p.R149H|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA|DUS1L_uc010wvi.1_Missense_Mutation_p.R132H	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	149					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			CGGGAAGACACGGATTTTGCA	0.602													T	80020801	T	T	80020801	3	4	184	1	0	0	0	0	1	0	0	0	4805	536	19	1	1015	1	DUS1L	17	80020801	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08	794502	80020801	1174409	36	13087											
ANKRD30B	374860	broad.mit.edu	37	chr18	14763986	14763986	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acatctgtaaagactgaatgCgtggcaggagtaacacctaa	10	8	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr18:14763986C>G	uc010dlo.2	+	7	1302	c.1122C>G	c.(1120-1122)TGC>TGG	p.C374W	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	374										ovary(1)|skin(1)	2						AGACTGAATGCGTGGCAGGAG	0.363													G	14763986	G	G	14763986	3	3	184	1	0	0	0	0	1	0	0	0	659	776	27	5	1148	5	ANKRD30B	18	14763986	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08		14763986	63313262	37	13088											
DSEL	92126	broad.mit.edu	37	chr18	65181103	65181103	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctacagcctgtttccatataTttgctttagatcctttatct	4	10	1	1			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr18:65181103T>C	uc002lke.1	-	2	1997	c.773A>G	c.(772-774)AAT>AGT	p.N258S		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	248						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				TTTCCATATATTTGCTTTAGA	0.418													C	65181103	C	C	65181103	3	2	184	1	0	0	0	0	1	0	0	0	4775	1493	52	4	2899	4	DSEL	18	65181103	Missense_Mutation	SNP	T	TCGA-27-1832-01A-01W-0643-08	50417117	65181103	12896145	38	13089											
KLK15	55554	broad.mit.edu	37	chr19	51330985	51330985	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaagcgccacagttaaagcGtccacgctcgtagagagcca	12	12	0	1	rs140896741	byFrequency	TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr19:51330985G>A	uc002ptl.2	-	2	161	c.130C>T	c.(130-132)CGC>TGC	p.R44C	KLK15_uc002ptm.2_Missense_Mutation_p.R44C|KLK15_uc002ptn.2_Missense_Mutation_p.R44C|KLK15_uc002pto.2_Missense_Mutation_p.R43C|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_Missense_Mutation_p.R43C|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	44	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CAGTTAAAGCGTCCACGCTCG	0.612													A	51330985	A	A	51330985	3	1	184	1	0	0	0	0	1	0	0	0	8403	1145	40	1	656	1	KLK15	19	51330985	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08		51330985	7797998	39	13090											
RRP1B	23076	broad.mit.edu	37	chr21	45113183	45113183	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgaagacccccaccagctcAcctgccagctcacccctggt	7	20	2	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr21:45113183A>C	uc002zdk.2	+	16	2310	c.2196A>C	c.(2194-2196)TCA>TCC	p.S732S	RRP1B_uc002zdl.2_Silent_p.S265S	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	732					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		CCACCAGCTCACCTGCCAGCT	0.612													C	45113183	C	C	45113183	2	2	184	1	0	0	0	0	0	0	0	1	13688	146	6	5		5	RRP1B	21	45113183	Silent	SNP	A	TCGA-27-1832-01A-01W-0643-08		45113183	3016712	40	13091											
C22orf42	150297	broad.mit.edu	37	chr22	32546408	32546408	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gataggctttcactgagatcCgatgtcatgaagtcttcaag	10	8	4	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr22:32546408C>T	uc003amd.2	-	7	593	c.552G>A	c.(550-552)TCG>TCA	p.S184S		NM_001010859	NP_001010859	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	184										ovary(1)|skin(1)	2						CACTGAGATCCGATGTCATGA	0.458													T	32546408	T	T	32546408	2	4	184	1	0	0	0	0	0	0	0	1	2149	639	23	2		2	C22orf42	22	32546408	Silent	SNP	C	TCGA-27-1832-01A-01W-0643-08		32546408	18758158	41	13092											
TMPRSS6	164656	broad.mit.edu	37	chr22	37469590	37469590	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	accttcctggcactgctcttCgtcgctgccgttgagacaat	9	14	1	1			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chr22:37469590C>T	uc003aqs.1	-	13	1678	c.1564G>A	c.(1564-1566)GAA>AAA	p.E522K	TMPRSS6_uc003aqt.1_Missense_Mutation_p.E513K	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	522	LDL-receptor class A 2.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						CACTGCTCTTCGTCGCTGCCG	0.552													T	37469590	T	T	37469590	3	4	184	1	0	0	0	0	1	0	0	0	16248	893	31	2	895	2	TMPRSS6	22	37469590	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08	4923182	37469590	13834976	42	13093											
STS	412	broad.mit.edu	37	chrX	7194035	7194035	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtcttgtcctacctccacGtgcacacagccctgttctcc	6	17	2	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chrX:7194035G>A	uc004cry.3	+	6	1110	c.865G>A	c.(865-867)GTG>ATG	p.V289M		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	289	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CTACCTCCACGTGCACACAGC	0.423									Ichthyosis				A	7194035	A	A	7194035	3	1	184	1	0	0	0	0	1	0	0	0	15331	1145	40	1	887	1	STS	23	7194035	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08		7194035	148076525	43	13094											
PHF16	9767	broad.mit.edu	37	chrX	46918293	46918293	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcagggagagctccatatcaGgaaaatgatggctattgccc	12	9	1	2			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chrX:46918293G>C	uc004dgx.2	+	11	2337	c.2286G>C	c.(2284-2286)CAG>CAC	p.Q762H	PHF16_uc004dgy.2_Missense_Mutation_p.Q762H	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	762					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						CTCCATATCAGGAAAATGATG	0.483													C	46918293	C	C	46918293	3	2	184	1	0	0	0	0	1	0	0	0	11827	991	35	5	2324	5	PHF16	23	46918293	Missense_Mutation	SNP	G	TCGA-27-1832-01A-01W-0643-08	39724258	46918293	108352267	44	13095											
SLC6A14	11254	broad.mit.edu	37	chrX	115582754	115582754	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaactgtctcactagcgtgTttgctggatttgctattttt	8	8	1	0			TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chrX:115582754T>G	uc004eqi.2	+	8	1182	c.1078T>G	c.(1078-1080)TTT>GTT	p.F360V		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	360	Helical; Name=7; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	CACTAGCGTGTTTGCTGGATT	0.358													G	115582754	G	G	115582754	3	3	184	1	0	0	0	0	1	0	0	0	14677	1725	60	5	1108	5	SLC6A14	23	115582754	Missense_Mutation	SNP	T	TCGA-27-1832-01A-01W-0643-08	68664461	115582754	39687806	45	13096											
CDR1	1038	broad.mit.edu	37	chrX	139865904	139865904	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagtcaatccacatcttcCggaaaaaatccaggtcttcc	5	14	3	0	rs143948461		TCGA-27-1832-01A-01W-0643-08	TCGA-27-1832-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	7ea7ee22-55a6-4748-9607-d93a6a367122	68a8c7ec-beb2-4ce0-8480-1b72210a5989	g.chrX:139865904C>T	uc004fbg.1	-	1	820	c.628G>A	c.(628-630)GGA>AGA	p.G210R	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	210											0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCACATCTTCCGGAAAAAATC	0.438													T	139865904	T	T	139865904	3	4	184	1	0	0	0	0	1	0	0	0	3171	661	23	2	164	2	CDR1	23	139865904	Missense_Mutation	SNP	C	TCGA-27-1832-01A-01W-0643-08	24283150	139865904	15404656	46	13097											
GJB3	2707	broad.mit.edu	37	chr1	35250842	35250842	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatggcttcaatatgccgcGcctggtgcagtgtgccaacg	13	12	1	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr1:35250842G>A	uc001bxx.2	+	2	1094	c.479G>A	c.(478-480)CGC>CAC	p.R160H	GJB3_uc001bxy.2_Missense_Mutation_p.R160H|GJB3_uc001bxz.3_Missense_Mutation_p.R160H|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	160	Extracellular (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				AATATGCCGCGCCTGGTGCAG	0.552													A	35250842	A	A	35250842	3	1	185	1	0	0	0	0	1	0	0	0	6409	1087	38	1	481	1	GJB3	1	35250842	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08		35250842	213999779	1	13098											
EPHA10	284656	broad.mit.edu	37	chr1	38227109	38227109	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccacgctcctggaatcccGcgctgcagctgcagcggccc	11	19	0	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr1:38227109G>A	uc009vvi.2	-	3	904	c.818C>T	c.(817-819)GCG>GTG	p.A273V	EPHA10_uc001cbw.3_Missense_Mutation_p.A273V	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	273	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTGGAATCCCGCGCTGCAGCT	0.677													A	38227109	A	A	38227109	3	1	185	1	0	0	0	0	1	0	0	0	5166	1087	38	1	2306	1	EPHA10	1	38227109	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	2976267	38227109	211023512	2	13099											
LRRIQ3	127255	broad.mit.edu	37	chr1	74507363	74507363	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcaatatcactaaatgttcGgagtttcataccagctcttt	6	9	4	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr1:74507363G>A	uc001dfy.3	-	7	1444	c.1252C>T	c.(1252-1254)CGA>TGA	p.R418*	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	418										ovary(2)	2						CTAAATGTTCGGAGTTTCATA	0.363													A	74507363	A	A	74507363	4	1	185	1	0	0	0	0	0	1	0	0	9030	1124	39	2	630	2	LRRIQ3	1	74507363	Nonsense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	36280254	74507363	174743258	3	13100											
NBPF9	400818	broad.mit.edu	37	chr1	144615288	144615288	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccggcttcctggccaacCgacagaagaaatacagtaag	11	11	0	2			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr1:144615288C>T	uc009wig.1	+	4	236	c.160C>T	c.(160-162)CGA>TGA	p.R54*	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_5'UTR|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_5'UTR|NBPF9_uc010oyg.1_Missense_Mutation_p.P53L|NBPF9_uc009wii.1_5'UTR|NBPF9_uc009wif.1_RNA|C1orf152_uc001elf.3_5'Flank	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	54						cytoplasm					0						CCTGGCCAACCGACAGAAGAA	0.448													T	144615288	T	T	144615288	4	4	185	1	0	0	0	0	0	1	0	0	10199	652	23	2	160	2	NBPF9	1	144615288	Nonsense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	70107925	144615288	104635333	4	13101											
ILDR2	387597	broad.mit.edu	37	chr1	166904584	166904584	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cttggtgccaagggaggtggAtgcggcttgtccatcagcat	15	9	1	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr1:166904584A>T	uc001gdx.1	-	6	890	c.834T>A	c.(832-834)CAT>CAA	p.H278Q		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	278	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						AGGGAGGTGGATGCGGCTTGT	0.617													T	166904584	T	T	166904584	3	4	185	1	0	0	0	0	1	0	0	0	7710	330	12	5	1105	5	ILDR2	1	166904584	Missense_Mutation	SNP	A	TCGA-27-1833-01A-01W-0643-08	22289296	166904584	82346037	5	13102											
CPS1	1373	broad.mit.edu	37	chr2	211481222	211481222	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggtttttgtataagatgCgtgatattttaaacatggaa	10	2	0	2	rs148519116		TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr2:211481222C>T	uc002vee.3	+	21	2776	c.2644C>T	c.(2644-2646)CGT>TGT	p.R882C	CPS1_uc010fur.2_Missense_Mutation_p.R888C|CPS1_uc010fus.2_Missense_Mutation_p.R431C|LOC29034_uc002vef.2_5'Flank	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	882					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GTATAAGATGCGTGATATTTT	0.408													T	211481222	T	T	211481222	3	4	185	1	0	0	0	0	1	0	0	0	3823	768	27	1	2748	1	CPS1	2	211481222	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08		211481222	31718151	6	13103											
NCL	4691	broad.mit.edu	37	chr2	232326477	232326477	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ttctttgcccccttggctggGatggcagcacccttcttacc	9	15	2	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr2:232326477G>T	uc002vru.2	-	3	528	c.387C>A	c.(385-387)ATC>ATA	p.I129I	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	129	8.|8 X 8 AA tandem repeats of X-T-P-X-K-K-X- X.				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		CCTTGGCTGGGATGGCAGCAC	0.393													T	232326477	T	T	232326477	2	4	185	1	0	0	0	0	0	0	0	1	10226	1164	41	5		5	NCL	2	232326477	Silent	SNP	G	TCGA-27-1833-01A-01W-0643-08	20845255	232326477	10872896	7	13104											
SH3BP4	23677	broad.mit.edu	37	chr2	235950763	235950763	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacctggagccctgtatgtaCgtggctgtcgtggcccatgg	14	11	0	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr2:235950763C>T	uc002vvp.2	+	4	1743	c.1350C>T	c.(1348-1350)TAC>TAT	p.Y450Y	SH3BP4_uc010fym.2_Silent_p.Y450Y|SH3BP4_uc002vvq.2_Silent_p.Y450Y	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	450					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CCTGTATGTACGTGGCTGTCG	0.577													T	235950763	T	T	235950763	2	4	185	1	0	0	0	0	0	0	0	1	14246	547	19	1		1	SH3BP4	2	235950763	Silent	SNP	C	TCGA-27-1833-01A-01W-0643-08	3624286	235950763	7248610	8	13105											
D2HGDH	728294	broad.mit.edu	37	chr2	242683167	242683167	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggggaaacgtggcaaccaaCgctggaggcctgcggtttct	16	10	1	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr2:242683167C>T	uc002wce.1	+	5	794	c.621C>T	c.(619-621)AAC>AAT	p.N207N	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Silent_p.N73N|D2HGDH_uc002wcg.1_RNA	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	207	FAD-binding PCMH-type.				2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TGGCAACCAACGCTGGAGGCC	0.617													T	242683167	T	T	242683167	2	4	185	1	0	0	0	0	0	0	0	1	4213	535	19	1		1	D2HGDH	2	242683167	Silent	SNP	C	TCGA-27-1833-01A-01W-0643-08	6732404	242683167	516206	9	13106											
CNTN6	27255	broad.mit.edu	37	chr3	1418745	1418745	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggaagtcggtctgaactcGtcattacgtgggaggtaatt	14	6	2	1	rs140014929		TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr3:1418745G>A	uc003boz.2	+	17	2419	c.2152G>A	c.(2152-2154)GTC>ATC	p.V718I	CNTN6_uc011asj.1_Missense_Mutation_p.V646I|CNTN6_uc003bpa.2_Missense_Mutation_p.V718I	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	718	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane		p.V718I(1)		skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GTCTGAACTCGTCATTACGTG	0.373													A	1418745	A	A	1418745	3	1	185	1	0	0	0	0	1	0	0	0	3645	1145	40	1	2214	1	CNTN6	3	1418745	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08		1418745	196603685	10	13107											
RARB	5915	broad.mit.edu	37	chr3	25215958	25215958	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgactcactatccagccacaCcctacccgttactctttcca	3	18	2	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr3:25215958C>A	uc011awl.1	+	1	136	c.70C>A	c.(70-72)CCC>ACC	p.P24T		NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	24	Modulating.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	TCCAGCCACACCCTACCCGTT	0.592													A	25215958	A	A	25215958	3	1	185	1	0	0	0	0	1	0	0	0	13053	522	18	5		5	RARB	3	25215958	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	23797213	25215958	172806472	11	13108											
CYP8B1	1582	broad.mit.edu	37	chr3	42916827	42916827	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcctcatgccagcaactgGcatccagactccagcctttg	8	15	1	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr3:42916827G>A	uc003cmh.2	-	1	807	c.482C>T	c.(481-483)GCC>GTC	p.A161V	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Missense_Mutation_p.A161V	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	161					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCAGCAACTGGCATCCAGACT	0.522													A	42916827	A	A	42916827	3	1	185	1	0	0	0	0	1	0	0	0	4198	1203	42	3	1027	3	CYP8B1	3	42916827	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	17700869	42916827	155105603	12	13109											
WHSC1	7468	broad.mit.edu	37	chr4	1955109	1955109	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatgttaagcgctgtgtggtAactcagtgtggaaaatttta	12	4	1	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr4:1955109A>G	uc003gdz.3	+	12	2372	c.2196A>G	c.(2194-2196)GTA>GTG	p.V732V	WHSC1_uc003geb.3_Silent_p.V732V|WHSC1_uc003gec.3_Silent_p.V732V|WHSC1_uc003ged.3_Silent_p.V732V|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_5'UTR|WHSC1_uc011bvh.1_5'UTR|WHSC1_uc010icf.2_Silent_p.V80V	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	732	PHD-type 2.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GCTGTGTGGTAACTCAGTGTG	0.458			T	IGH@	MM								G	1955109	G	G	1955109	2	3	185	1	0	0	0	0	0	0	0	1	17359	349	13	4		4	WHSC1	4	1955109	Silent	SNP	A	TCGA-27-1833-01A-01W-0643-08		1955109	189199167	13	13110											
PAM	5066	broad.mit.edu	37	chr5	102360910	102360911	+	Frame_Shift_Del	DEL	AG	-	-													gcagaagatgcaagagaaacAgaaactgatcaaagagccag							TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr5:102360910_102360911delAG	uc003knw.2	+	23	2934_2935	c.2561_2562delAG	c.(2560-2562)CAGfs	p.Q854fs	PAM_uc003kns.2_Frame_Shift_Del_p.Q747fs|PAM_uc003knt.2_Frame_Shift_Del_p.Q854fs|PAM_uc003knu.2_Intron|PAM_uc003knv.2_Intron|PAM_uc011cuz.1_Frame_Shift_Del_p.Q756fs|PAM_uc003knz.2_Frame_Shift_Del_p.Q94fs	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	854	Intragranular (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	CAAGAGAAACAGAAACTGATCA	0.46													-	102360911	-	-	102360910	7	5	185	1	0	1	0	1	0	0	0	0	11412	188	7	0	2651	0	PAM	5	102360910	Frame_Shift_Del	DEL	AG	TCGA-27-1833-01A-01W-0643-08		102360910	78554350	14	13111											
PKHD1	5314	broad.mit.edu	37	chr6	51523917	51523917	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagtgctccttactgttggCgaatcaccaatttcaatgac	7	12	2	1	rs142855690	by1000genomes	TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr6:51523917C>T	uc003pah.1	-	61	11283	c.11007G>A	c.(11005-11007)TCG>TCA	p.S3669S		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3669	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TTACTGTTGGCGAATCACCAA	0.423													T	51523917	T	T	51523917	2	4	185	1	0	0	0	0	0	0	0	1	11971	755	27	1		1	PKHD1	6	51523917	Silent	SNP	C	TCGA-27-1833-01A-01W-0643-08		51523917	119591150	15	13112											
TRAF3IP2	10758	broad.mit.edu	37	chr6	111912560	111912560	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catctgtgcacatgctggatAcctctgaggttcaaactgag	10	10	3	2			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr6:111912560A>G	uc011ebc.1	-	3	1345	c.730T>C	c.(730-732)TAT>CAT	p.Y244H	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.Y244H|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.Y244H|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.Y244H|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.Y244H	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	253					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		CATGCTGGATACCTCTGAGGT	0.572													G	111912560	G	G	111912560	3	3	185	1	0	0	0	0	1	0	0	0	16438	391	14	4	999	4	TRAF3IP2	6	111912560	Missense_Mutation	SNP	A	TCGA-27-1833-01A-01W-0643-08	60388643	111912560	59202507	16	13113											
PON1	5444	broad.mit.edu	37	chr7	94953757	94953757	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaagagtgccagtcccatccCcaagagggtgagcgcaatca	12	12	1	3			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr7:94953757C>A	uc003uns.2	-	1	128	c.31G>T	c.(31-33)GGG>TGG	p.G11W	PON1_uc011kih.1_Intron	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	11					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	AGTCCCATCCCCAAGAGGGTG	0.607													A	94953757	A	A	94953757	3	1	185	1	0	0	0	0	1	0	0	0	12248	623	22	5	1072	5	PON1	7	94953757	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08		94953757	64184906	17	13114											
TRRAP	8295	broad.mit.edu	37	chr7	98580929	98580935	+	Frame_Shift_Del	DEL	AACGCAG	-	-													tccaggaagctgcacaaatcAacgcaggcttacagccaacc							TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr7:98580929_98580935delAACGCAG	uc003upp.2	+	59	9057_9063	c.8848_8854delAACGCAG	c.(8848-8856)AACGCAGGCfs	p.N2950fs	TRRAP_uc011kis.1_Frame_Shift_Del_p.N2932fs|TRRAP_uc003upr.2_Frame_Shift_Del_p.N2649fs	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2950_2952	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGCACAAATCAACGCAGGCTTACAGCC	0.522													-	98580935	-	-	98580929	7	5	185	1	0	1	0	1	0	0	0	0	16598	130	5	0	9020	0	TRRAP	7	98580929	Frame_Shift_Del	DEL	AACGCAG	TCGA-27-1833-01A-01W-0643-08	3627172	98580929	60557734	18	13115											
PIK3CG	5294	broad.mit.edu	37	chr7	106513286	106513286	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtggcacagccatgctgcaCgactttacccaacaagtcca	8	14	0	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr7:106513286C>T	uc003vdv.3	+	4	2275	c.2190C>T	c.(2188-2190)CAC>CAT	p.H730H	PIK3CG_uc003vdu.2_Silent_p.H730H|PIK3CG_uc003vdw.2_Silent_p.H730H	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	730					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CCATGCTGCACGACTTTACCC	0.473													T	106513286	T	T	106513286	2	4	185	1	0	0	0	0	0	0	0	1	11916	535	19	1		1	PIK3CG	7	106513286	Silent	SNP	C	TCGA-27-1833-01A-01W-0643-08	7932357	106513286	52625377	19	13116											
AKR1B15	441282	broad.mit.edu	37	chr7	134260192	134260192	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccatggaggagctggtggaCgaggggctggtgaaagccct	19	8	0	1	rs4035285		TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr7:134260192C>T	uc011kpr.1	+	7	833	c.534C>T	c.(532-534)GAC>GAT	p.D178D	AKR1B15_uc011kps.1_Silent_p.D150D	NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	178							oxidoreductase activity			ovary(1)	1						AGCTGGTGGACGAGGGGCTGG	0.517													T	134260192	T	T	134260192	2	4	185	1	0	0	0	0	0	0	0	1	468	535	19	1		1	AKR1B15	7	134260192	Silent	SNP	C	TCGA-27-1833-01A-01W-0643-08	27746906	134260192	24878471	20	13117											
MLL3	58508	broad.mit.edu	37	chr7	151877846	151877846	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catatttacagtattctgtgTatcagttactcctgaagttg	7	7	2	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr7:151877846T>C	uc003wla.2	-	36	7318	c.7099A>G	c.(7099-7101)ACA>GCA	p.T2367A	MLL3_uc003wkz.2_Missense_Mutation_p.T1428A|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2367					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GTATTCTGTGTATCAGTTACT	0.428			N		medulloblastoma								C	151877846	C	C	151877846	3	2	185	1	0	0	0	0	1	0	0	0	9622	1638	57	4	7732	4	MLL3	7	151877846	Missense_Mutation	SNP	T	TCGA-27-1833-01A-01W-0643-08	17617654	151877846	7260817	21	13118											
FLJ43860	389690	broad.mit.edu	37	chr8	142476586	142476586	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggccagcagggtgatggcGtgcagggtcttttccttggc	17	10	1	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr8:142476586G>A	uc003ywi.2	-	19	2481	c.2400C>T	c.(2398-2400)CAC>CAT	p.H800H	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	800							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGGTGATGGCGTGCAGGGTCT	0.632													A	142476586	A	A	142476586	2	1	185	1	0	0	0	0	0	0	0	1	5930	1136	40	1		1	FLJ43860	8	142476586	Silent	SNP	G	TCGA-27-1833-01A-01W-0643-08		142476586	3887436	22	13119											
HSF1	3297	broad.mit.edu	37	chr8	145537533	145537533	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagcccctcggtgaccgtgCccgacatgagcctgcctgac	11	17	1	3			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr8:145537533C>T	uc003zbt.3	+	11	1443	c.1273C>T	c.(1273-1275)CCC>TCC	p.P425S	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	425	Transactivation domain.					cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			GGTGACCGTGCCCGACATGAG	0.532													T	145537533	T	T	145537533	3	4	185	1	0	0	0	0	1	0	0	0	7395	739	26	3	1315	3	HSF1	8	145537533	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	3060947	145537533	826489	23	13120											
EXD3	54932	broad.mit.edu	37	chr9	140201615	140201615	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgcagccgggtgccgtcGgccagcatgtccggtgtctc	15	14	1	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr9:140201615G>A	uc004cmp.2	-	22	2614	c.2418C>T	c.(2416-2418)GCC>GCT	p.A806A	C9orf167_uc011mew.1_Intron|EXD3_uc010ncf.1_Silent_p.A444A	NM_017820	NP_060290	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	806					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						GGGTGCCGTCGGCCAGCATGT	0.697													A	140201615	A	A	140201615	2	1	185	1	0	0	0	0	0	0	0	1	5299	1103	39	2		2	EXD3	9	140201615	Silent	SNP	G	TCGA-27-1833-01A-01W-0643-08		140201615	1011816	24	13121											
MPP7	143098	broad.mit.edu	37	chr10	28345469	28345469	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ataatctttgcattttttctTgtttctctcaaacgctctat	3	9	5	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr10:28345469T>C	uc001iua.1	-	18	1895	c.1491A>G	c.(1489-1491)ACA>ACG	p.T497T	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Silent_p.T497T|MPP7_uc009xla.2_Silent_p.T497T|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	497	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						CATTTTTTCTTGTTTCTCTCA	0.333													C	28345469	C	C	28345469	2	2	185	1	0	0	0	0	0	0	0	1	9739	1799	63	4		4	MPP7	10	28345469	Silent	SNP	T	TCGA-27-1833-01A-01W-0643-08		28345469	107189278	25	13122											
OGDHL	55753	broad.mit.edu	37	chr10	50943387	50943387	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtgcagccgctgggtcccGgccaacatacctggaggagg	16	12	0	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr10:50943387G>A	uc001jie.2	-	23	3062	c.2920C>T	c.(2920-2922)CGG>TGG	p.R974W	OGDHL_uc009xog.2_Missense_Mutation_p.R1001W|OGDHL_uc010qgt.1_Missense_Mutation_p.R917W|OGDHL_uc010qgu.1_Missense_Mutation_p.R765W	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	974					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GCTGGGTCCCGGCCAACATAC	0.622													A	50943387	A	A	50943387	3	1	185	1	0	0	0	0	1	0	0	0	10840	1115	39	2	116	2	OGDHL	10	50943387	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	22597918	50943387	84591360	26	13123											
A1CF	29974	broad.mit.edu	37	chr10	52596064	52596064	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcacaaacccctaagaggCgcccatttctgcaaaaagag	9	12	1	2	rs148254279		TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr10:52596064C>T	uc001jjj.2	-	6	562	c.374G>A	c.(373-375)CGC>CAC	p.R125H	A1CF_uc010qhn.1_Missense_Mutation_p.R133H|A1CF_uc001jji.2_Missense_Mutation_p.R125H|A1CF_uc001jjh.2_Missense_Mutation_p.R133H|A1CF_uc010qho.1_Missense_Mutation_p.R133H|A1CF_uc009xov.2_Missense_Mutation_p.R125H	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	125	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						CCCTAAGAGGCGCCCATTTCT	0.438													T	52596064	T	T	52596064	3	4	185	1	0	0	0	0	1	0	0	0	2	768	27	1	1442	1	A1CF	10	52596064	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	1652677	52596064	82938683	27	13124											
CNNM1	26507	broad.mit.edu	37	chr10	101147663	101147663	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacatggaggccttcacagaCggggactccactaaggcccc	12	14	1	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr10:101147663C>T	uc001kpp.3	+	8	2716	c.2427C>T	c.(2425-2427)GAC>GAT	p.D809D	CNNM1_uc010qpi.1_Silent_p.D830D|CNNM1_uc009xwf.2_Silent_p.D809D|CNNM1_uc009xwg.2_Silent_p.D209D	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	809					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		CCTTCACAGACGGGGACTCCA	0.602													T	101147663	T	T	101147663	2	4	185	1	0	0	0	0	0	0	0	1	3612	535	19	1		1	CNNM1	10	101147663	Silent	SNP	C	TCGA-27-1833-01A-01W-0643-08	48551599	101147663	34387084	28	13125											
DCHS1	8642	broad.mit.edu	37	chr11	6654846	6654846	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcaccacagaattggccCgtctggccaagggccaggct	13	14	1	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr11:6654846C>T	uc001mem.1	-	5	2662	c.2252G>A	c.(2251-2253)CGG>CAG	p.R751Q		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	751	Cadherin 7.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAATTGGCCCGTCTGGCCAA	0.547													T	6654846	T	T	6654846	3	4	185	1	0	0	0	0	1	0	0	0	4287	652	23	2	7712	2	DCHS1	11	6654846	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08		6654846	128351670	29	13126											
OR4C6	219432	broad.mit.edu	37	chr11	55432767	55432767	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cacagtgctggaaaatctacTtattgtggtaactattatca	7	7	2	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr11:55432767T>A	uc001nht.3	+	3	390	c.125T>A	c.(124-126)CTT>CAT	p.L42H	OR4C6_uc010rik.1_Missense_Mutation_p.L42H	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GAAAATCTACTTATTGTGGTA	0.393													A	55432767	A	A	55432767	3	1	185	1	0	0	0	0	1	0	0	0	11052	1609	56	5	127	5	OR4C6	11	55432767	Missense_Mutation	SNP	T	TCGA-27-1833-01A-01W-0643-08	48777921	55432767	79573749	30	13127											
TMEM109	79073	broad.mit.edu	37	chr11	60687272	60687272	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcagcattggcccagtcccGtcgagactttgcaccaccag	9	16	1	1	rs139328208		TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr11:60687272G>A	uc001nqg.2	+	2	485	c.107G>A	c.(106-108)CGT>CAT	p.R36H	TMEM109_uc001nqh.2_Missense_Mutation_p.R36H	NM_024092	NP_076997	Q9BVC6	TM109_HUMAN	transmembrane protein 109 precursor	36						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane					0						GCCCAGTCCCGTCGAGACTTT	0.547													A	60687272	A	A	60687272	3	1	185	1	0	0	0	0	1	0	0	0	16022	1145	40	1	109	1	TMEM109	11	60687272	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	5254505	60687272	74319244	31	13128											
NXF1	10482	broad.mit.edu	37	chr11	62561731	62561731	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacatgccccgcactcactTctgggaccactcgaggttca	8	16	3	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr11:62561731T>C	uc001nvf.1	-	19	1895	c.1759A>G	c.(1759-1761)AAG>GAG	p.K587E	TMEM223_uc001nve.2_5'Flank|NXF1_uc001nvg.1_3'UTR|NXF1_uc009yog.1_3'UTR	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	587	TAP-C.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						CGCACTCACTTCTGGGACCAC	0.493													C	62561731	C	C	62561731	3	2	185	1	0	0	0	0	1	0	0	0	10782	1797	62	4	112	4	NXF1	11	62561731	Missense_Mutation	SNP	T	TCGA-27-1833-01A-01W-0643-08	1874459	62561731	72444785	32	13129											
MAP4K2	5871	broad.mit.edu	37	chr11	64559447	64559448	+	Frame_Shift_Ins	INS	-	G	G													acatggaacaggacgcggcaINSgccgggcccctcaggcccct							TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr11:64559447_64559448insG	uc001obh.2	-	27	2117_2118	c.2025_2026insC	c.(2023-2028)GGCTGCfs	p.G675fs	MAP4K2_uc001obg.2_RNA|MAP4K2_uc001obi.2_Frame_Shift_Ins_p.G667fs	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	675_676	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						AGGACGCGGCAGCCGGGCCCCT	0.708													G	64559448	G	G	64559447	7	5	185	1	0	1	1	0	0	0	0	0	9260	188	7	0	460	0	MAP4K2	11	64559447	Frame_Shift_Ins	INS	-	TCGA-27-1833-01A-01W-0643-08	1997716	64559447	70447069	33	13130											
SLCO1B3	28234	broad.mit.edu	37	chr12	21229466	21229466	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccaacagctgtggagcaCgaggggcttgtaggatatat	13	9	0	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr12:21229466C>T	uc010sil.1	+	15	2076	c.2011C>T	c.(2011-2013)CGA>TGA	p.R671*	LST-3TM12_uc010sim.1_Nonsense_Mutation_p.R610*|LST-3TM12_uc010sin.1_Nonsense_Mutation_p.R563*			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CTGTGGAGCACGAGGGGCTTG	0.353													T	21229466	T	T	21229466	4	4	185	1	0	0	0	0	0	1	0	0	14724	528	19	1		1	SLCO1B3	12	21229466	Nonsense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08		21229466	112622429	34	13131											
STAC3	246329	broad.mit.edu	37	chr12	57642900	57642900	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaatttgtggggcttatcGttgaccagcttaggaggttc	13	6	0	2	rs148939626		TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr12:57642900G>A	uc001snp.2	-	3	453	c.258C>T	c.(256-258)AAC>AAT	p.N86N	STAC3_uc009zpl.2_Intron|STAC3_uc001snq.2_Silent_p.N47N|STAC3_uc010srm.1_Intron	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	86					intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						GGGGCTTATCGTTGACCAGCT	0.408													A	57642900	A	A	57642900	2	1	185	1	0	0	0	0	0	0	0	1	15240	1136	40	1		1	STAC3	12	57642900	Silent	SNP	G	TCGA-27-1833-01A-01W-0643-08	36413434	57642900	76208995	35	13132											
SACS	26278	broad.mit.edu	37	chr13	23908788	23908788	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacagtggtaaagattagcaGtttcatcacagttataaacc	8	7	2	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr13:23908788G>T	uc001uon.2	-	10	9816	c.9227C>A	c.(9226-9228)ACT>AAT	p.T3076N	SACS_uc001uoo.2_Missense_Mutation_p.T2929N|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3076					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAGATTAGCAGTTTCATCACA	0.358													T	23908788	T	T	23908788	3	4	185	1	0	0	0	0	1	0	0	0	13804	1029	36	5	4516	5	SACS	13	23908788	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08		23908788	91261090	36	13133											
SPTB	6710	broad.mit.edu	37	chr14	65270332	65270332	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccaggaacccacctggaagCggaggatgatggtccagatg	14	11	0	2			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr14:65270332C>T	uc001xht.2	-	3	521	c.467G>A	c.(466-468)CGC>CAC	p.R156H	SPTB_uc001xhr.2_Missense_Mutation_p.R156H|SPTB_uc001xhs.2_Missense_Mutation_p.R156H|SPTB_uc001xhu.2_Missense_Mutation_p.R156H	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	156	CH 1.|Actin-binding.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CACCTGGAAGCGGAGGATGAT	0.572													T	65270332	T	T	65270332	3	4	185	1	0	0	0	0	1	0	0	0	15117	768	27	1	6720	1	SPTB	14	65270332	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08		65270332	42079208	37	13134											
WDR72	256764	broad.mit.edu	37	chr15	53992060	53992060	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aaaggtgcttccgggcatgcAggaggcaactctttccctca	11	12	2	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr15:53992060A>T	uc002acj.2	-	13	1694	c.1652T>A	c.(1651-1653)CTG>CAG	p.L551Q	WDR72_uc010bfi.1_Missense_Mutation_p.L551Q	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	551	WD 7.									lung(1)|skin(1)	2				all cancers(107;0.0511)		CCGGGCATGCAGGAGGCAACT	0.463													T	53992060	T	T	53992060	3	4	185	1	0	0	0	0	1	0	0	0	17319	188	7	5	1688	5	WDR72	15	53992060	Missense_Mutation	SNP	A	TCGA-27-1833-01A-01W-0643-08		53992060	48539332	38	13135											
MEF2A	4205	broad.mit.edu	37	chr15	100230497	100230497	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatttgattggagctactgGtgcaaatagcttaggcaaag	11	5	0	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr15:100230497G>A	uc010urw.1	+	7	1087	c.728G>A	c.(727-729)GGT>GAT	p.G243D	MEF2A_uc010urv.1_Missense_Mutation_p.G173D|MEF2A_uc010bos.2_Missense_Mutation_p.G241D|MEF2A_uc002bvf.2_Missense_Mutation_p.G243D|MEF2A_uc002bve.2_Missense_Mutation_p.G241D|MEF2A_uc002bvg.2_Missense_Mutation_p.G241D|MEF2A_uc002bvi.2_Missense_Mutation_p.G241D|MEF2A_uc010bot.2_Missense_Mutation_p.G173D	NM_005587	NP_005578	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A isoform 1	243					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			ovary(1)	1	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			GGAGCTACTGGTGCAAATAGC	0.413													A	100230497	A	A	100230497	3	1	185	1	0	0	0	0	1	0	0	0	9455	1261	44	3	886	3	MEF2A	15	100230497	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	46238437	100230497	2300895	39	13136											
CACNA1H	8912	broad.mit.edu	37	chr16	1255218	1255218	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcctgcggccctctgggctaCatccggaacccgtacaacat	10	16	1	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr16:1255218C>A	uc002cks.2	+	11	2804	c.2556C>A	c.(2554-2556)TAC>TAA	p.Y852*	CACNA1H_uc002ckt.2_Nonsense_Mutation_p.Y852*	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	852	II.|Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CTCTGGGCTACATCCGGAACC	0.597													A	1255218	A	A	1255218	4	1	185	1	0	0	0	0	0	1	0	0	2545	489	17	5	2594	5	CACNA1H	16	1255218	Nonsense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08		1255218	89099535	40	13137											
MAPK8IP3	23162	broad.mit.edu	37	chr16	1816093	1816093	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacccgctgcaacgtgccgcGgagcaactgctcctcccgag	11	18	0	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr16:1816093G>A	uc002cmk.2	+	21	2696	c.2576G>A	c.(2575-2577)CGG>CAG	p.R859Q	MAPK8IP3_uc002cml.2_Missense_Mutation_p.R853Q|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.R860Q	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	859					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						AACGTGCCGCGGAGCAACTGC	0.662													A	1816093	A	A	1816093	3	1	185	1	0	0	0	0	1	0	0	0	9286	1116	39	2	2674	2	MAPK8IP3	16	1816093	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	560875	1816093	88538660	41	13138											
SCNN1G	6340	broad.mit.edu	37	chr16	23200784	23200784	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttccagagtcccggaagcGccgagaggcggagtcctgga	15	12	0	2			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr16:23200784G>A	uc002dlm.1	+	3	549	c.410G>A	c.(409-411)CGC>CAC	p.R137H		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	137	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TCCCGGAAGCGCCGAGAGGCG	0.577													A	23200784	A	A	23200784	3	1	185	1	0	0	0	0	1	0	0	0	13930	1087	38	1	416	1	SCNN1G	16	23200784	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	21384691	23200784	67153969	42	13139											
IL4R	3566	broad.mit.edu	37	chr16	27357789	27357789	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gaggccgcttctcccgcagtGaaacccagggccccaggaaa	12	15	1	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr16:27357789G>A	uc002don.2	+	6	605	c.363G>A	c.(361-363)GTG>GTA	p.V121V	IL4R_uc002dom.2_Silent_p.V121V|IL4R_uc002dop.3_Silent_p.V106V|IL4R_uc010bxy.2_Silent_p.V121V|IL4R_uc002doo.2_5'UTR	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	121	Extracellular (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						CTCCCGCAGTGAAACCCAGGG	0.567													A	27357789	A	A	27357789	2	1	185	1	0	0	0	0	0	0	0	1	7698	1304	45	3		3	IL4R	16	27357789	Silent	SNP	G	TCGA-27-1833-01A-01W-0643-08	4157005	27357789	62996964	43	13140											
DNAH9	1770	broad.mit.edu	37	chr17	11684359	11684359	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctctggaaaagaaggctgGcagaaactatggccctccag	12	11	1	2			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr17:11684359G>A	uc002gne.2	+	39	7654	c.7586G>A	c.(7585-7587)GGC>GAC	p.G2529D	DNAH9_uc010coo.2_Missense_Mutation_p.G1823D	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2529	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AAGAAGGCTGGCAGAAACTAT	0.542													A	11684359	A	A	11684359	3	1	185	1	0	0	0	0	1	0	0	0	4608	1203	42	3	7740	3	DNAH9	17	11684359	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08		11684359	69510851	44	13141											
CDRT15	146822	broad.mit.edu	37	chr17	14140072	14140072	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgagggatgagccttcttcGgcatcgtcggaaaaggctct	14	9	2	2	rs147270904	byFrequency	TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr17:14140072G>A	uc010vvu.1	-	1	79	c.79C>T	c.(79-81)CGA>TGA	p.R27*	CDRT15_uc010coq.2_RNA	NM_001007530	NP_001007531	Q96T59	CDRTF_HUMAN	CMT1A duplicated region transcript 15	27											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGCCTTCTTCGGCATCGTCGG	0.597													A	14140072	A	A	14140072	4	1	185	1	0	0	0	0	0	1	0	0	3175	1124	39	2	497	2	CDRT15	17	14140072	Nonsense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	2455713	14140072	67055138	45	13142											
CCL3	6348	broad.mit.edu	37	chr17	34416095	34416095	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcacagacctgccggcttcGcttggttaggaagctgtgga	14	10	0	1	rs5029409		TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr17:34416095G>A	uc002hkv.2	-	3	304	c.202C>T	c.(202-204)CGA>TGA	p.R68*		NM_002983	NP_002974	P10147	CCL3_HUMAN	chemokine (C-C motif) ligand 3	68		Involved in GAG binding.		R->A: Strongly reduces heparin binding.	cell-cell signaling|cellular calcium ion homeostasis|cellular component movement|cytoskeleton organization|exocytosis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|regulation of viral genome replication	extracellular space|soluble fraction	chemoattractant activity|chemokine activity|signal transducer activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCCGGCTTCGCTTGGTTAGG	0.597													A	34416095	A	A	34416095	4	1	185	1	0	0	0	0	0	1	0	0	2901	1095	38	1	80	1	CCL3	17	34416095	Nonsense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	20276023	34416095	46779115	46	13143											
JUP	3728	broad.mit.edu	37	chr17	39680449	39680449	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccctgaagggtgcgccgcagGtcagtaacctcggacctgct	13	14	1	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr17:39680449G>T	uc010wfs.1	-	8	1391	c.1383C>A	c.(1381-1383)GAC>GAA	p.D461E	KRT15_uc002hxb.1_5'Flank|uc002hxc.1_5'Flank|KRT19_uc002hxd.3_Missense_Mutation_p.D298E	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	Error:Variant_position_missing_in_P14923_after_alignment					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		TGCGCCGCAGGTCAGTAACCT	0.577													T	39680449	T	T	39680449	3	4	185	1	0	0	0	0	1	0	0	0	7972	1252	44	5		5	JUP	17	39680449	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	5264354	39680449	41514761	47	13144											
IGF2BP1	10642	broad.mit.edu	37	chr17	47115648	47115648	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gccgagggggctttggctctCggggtcagccccgccagggc	18	14	2	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr17:47115648C>T	uc002iom.2	+	6	854	c.520C>T	c.(520-522)CGG>TGG	p.R174W	IGF2BP1_uc010dbj.2_Intron	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	174					CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						CTTTGGCTCTCGGGGTCAGCC	0.652													T	47115648	T	T	47115648	3	4	185	1	0	0	0	0	1	0	0	0	7573	875	31	2	542	2	IGF2BP1	17	47115648	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	7435199	47115648	34079562	48	13145											
SOX9	6662	broad.mit.edu	37	chr17	70117782	70117782	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcagccaggtgctcaaaggcTacgactggacgctggtgccc	13	13	2	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr17:70117782T>G	uc002jiw.2	+	1	622	c.250T>G	c.(250-252)TAC>GAC	p.Y84D	uc002jiv.2_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	84					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			GCTCAAAGGCTACGACTGGAC	0.637													G	70117782	G	G	70117782	3	3	185	1	0	0	0	0	1	0	0	0	14958	1522	53	5	252	5	SOX9	17	70117782	Missense_Mutation	SNP	T	TCGA-27-1833-01A-01W-0643-08	23002134	70117782	11077428	49	13146											
EPB41L3	23136	broad.mit.edu	37	chr18	5406824	5406824	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggcatcctcctgcctggcGgccagtcgcacgggggaggt	18	13	0	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr18:5406824G>A	uc002kmt.1	-	16	2387	c.2301C>T	c.(2299-2301)GCC>GCT	p.A767A	EPB41L3_uc010wzh.1_Silent_p.A598A|EPB41L3_uc002kmu.1_Silent_p.A586A|EPB41L3_uc010dkq.1_Silent_p.A477A|EPB41L3_uc002kms.1_Silent_p.A39A|EPB41L3_uc010wze.1_Silent_p.A39A|EPB41L3_uc010wzf.1_Silent_p.A39A|EPB41L3_uc010wzg.1_Silent_p.A39A|EPB41L3_uc010dkr.2_Silent_p.A159A	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	767	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CCTGCCTGGCGGCCAGTCGCA	0.527													A	5406824	A	A	5406824	2	1	185	1	0	0	0	0	0	0	0	1	5154	1103	39	2		2	EPB41L3	18	5406824	Silent	SNP	G	TCGA-27-1833-01A-01W-0643-08		5406824	72670424	50	13147											
SERPINB2	5055	broad.mit.edu	37	chr18	61569672	61569672	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtacagatgatgtacttgcGtgaaaagctaaacattggat	10	5	0	3			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr18:61569672G>A	uc010xeu.1	+	8	1046	c.713G>A	c.(712-714)CGT>CAT	p.R238H	SERPINB2_uc002ljo.2_Missense_Mutation_p.R238H|SERPINB2_uc010dqh.2_Missense_Mutation_p.R168H|SERPINB2_uc002ljp.1_Missense_Mutation_p.R43H|SERPINB2_uc002ljq.1_Missense_Mutation_p.R43H	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	238					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	ATGTACTTGCGTGAAAAGCTA	0.363													A	61569672	A	A	61569672	3	1	185	1	0	0	0	0	1	0	0	0	14101	1145	40	1	735	1	SERPINB2	18	61569672	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	56162848	61569672	16507576	51	13148											
CACNA1A	773	broad.mit.edu	37	chr19	13410023	13410023	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtctggccgcaggtgccgCgtgtaggcagccttccagcg	15	13	1	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr19:13410023C>T	uc010dze.2	-	19	2663	c.2427G>A	c.(2425-2427)ACG>ACA	p.T809T	CACNA1A_uc010dzc.2_Silent_p.T334T|CACNA1A_uc002mwy.3_Silent_p.T808T|CACNA1A_uc010xne.1_Silent_p.T337T	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	809	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCAGGTGCCGCGTGTAGGCAG	0.642													T	13410023	T	T	13410023	2	4	185	1	0	0	0	0	0	0	0	1	2538	755	27	1		1	CACNA1A	19	13410023	Silent	SNP	C	TCGA-27-1833-01A-01W-0643-08		13410023	45718960	52	13149											
FCGBP	8857	broad.mit.edu	37	chr19	40368357	40368357	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaccccagcggcctggcaggCggccacgtaggaagccagag	15	14	0	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr19:40368357C>T	uc002omp.3	-	28	12999	c.12991G>A	c.(12991-12993)GCC>ACC	p.A4331T		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4331						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCTGGCAGGCGGCCACGTAG	0.647													T	40368357	T	T	40368357	3	4	185	1	0	0	0	0	1	0	0	0	5778	768	27	1	3262	1	FCGBP	19	40368357	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	26958334	40368357	18760626	53	13150											
B3GNT8	374907	broad.mit.edu	37	chr19	41932065	41932066	+	Frame_Shift_Del	DEL	TG	-	-													gtcccagagcagcaggtcacTgtagcgacggctctcccagg							TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr19:41932065_41932066delTG	uc002oqs.2	-	3	1072_1073	c.618_619delCA	c.(616-621)TACAGTfs	p.Y206fs	CYP2F1_uc010xvw.1_Intron|B3GNT8_uc002oqt.1_Intron	NM_198540	NP_940942	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal	206_207	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity				0						AGCAGGTCACTGTAGCGACGGC	0.653													-	41932066	-	-	41932065	7	5	185	1	0	1	0	1	0	0	0	0	1263	1580	55	0	578	0	B3GNT8	19	41932065	Frame_Shift_Del	DEL	TG	TCGA-27-1833-01A-01W-0643-08	1563708	41932065	17196918	54	13151											
GPR4	2828	broad.mit.edu	37	chr19	46094683	46094683	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacaggggcgccgagttggCgcccagctccgtggcccaga	16	14	0	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr19:46094683C>T	uc002pcm.2	-	2	1387	c.442G>A	c.(442-444)GCC>ACC	p.A148T	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	148	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		GCCGAGTTGGCGCCCAGCTCC	0.672													T	46094683	T	T	46094683	3	4	185	1	0	0	0	0	1	0	0	0	6694	768	27	1	650	1	GPR4	19	46094683	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	4162618	46094683	13034300	55	13152											
GPR4	2828	broad.mit.edu	37	chr19	46094825	46094825	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaggcgatgctgatgtagatAttggtgtagaagatgaaccc	13	5	0	5			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr19:46094825A>G	uc002pcm.2	-	2	1245	c.300T>C	c.(298-300)AAT>AAC	p.N100N	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	100	Helical; Name=3; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		TGATGTAGATATTGGTGTAGA	0.622													G	46094825	G	G	46094825	2	3	185	1	0	0	0	0	0	0	0	1	6694	446	16	4		4	GPR4	19	46094825	Silent	SNP	A	TCGA-27-1833-01A-01W-0643-08	142	46094825	13034158	56	13153											
CCDC114	93233	broad.mit.edu	37	chr19	48807021	48807021	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctgggaggtcttccagaCgccctcggccacctccccgg	11	19	1	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr19:48807021C>T	uc002pir.2	-	8	1446	c.763G>A	c.(763-765)GTC>ATC	p.V255I	CCDC114_uc002piq.2_Missense_Mutation_p.V64I|CCDC114_uc002pio.2_Missense_Mutation_p.V292I|CCDC114_uc002pis.1_5'Flank|CCDC114_uc002pit.1_Missense_Mutation_p.V292I|CCDC114_uc002piu.1_Missense_Mutation_p.V292I	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	255										ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GTCTTCCAGACGCCCTCGGCC	0.632													T	48807021	T	T	48807021	3	4	185	1	0	0	0	0	1	0	0	0	2751	536	19	1	1277	1	CCDC114	19	48807021	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	2712196	48807021	10321962	57	13154											
CD33	945	broad.mit.edu	37	chr19	51728525	51728525	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaagtgcaggagtcagtgaCggtacaggagggtttgtgcg	18	6	1	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr19:51728525C>T	uc002pwa.2	+	2	129	c.89C>T	c.(88-90)ACG>ATG	p.T30M	CD33_uc010eos.1_Missense_Mutation_p.T30M|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	30	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GAGTCAGTGACGGTACAGGAG	0.582													T	51728525	T	T	51728525	3	4	185	1	0	0	0	0	1	0	0	0	3005	536	19	1	95	1	CD33	19	51728525	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	2921504	51728525	7400458	58	13155											
CD33	945	broad.mit.edu	37	chr19	51729331	51729331	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagaaccatccagctcaacGtcacctgtaagtgctgggcc	10	13	2	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr19:51729331G>A	uc002pwa.2	+	3	731	c.691G>A	c.(691-693)GTC>ATC	p.V231I	CD33_uc010eos.1_Missense_Mutation_p.V231I|CD33_uc010eot.1_Missense_Mutation_p.V104I|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	231	Extracellular (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CCAGCTCAACGTCACCTGTAA	0.607													A	51729331	A	A	51729331	3	1	185	1	0	0	0	0	1	0	0	0	3005	1145	40	1	701	1	CD33	19	51729331	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	806	51729331	7399652	59	13156											
SEMG2	6407	broad.mit.edu	37	chr20	43851621	43851621	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggcaagtctcaaaaccagGtaacaattcctagtcaagat	7	9	2	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr20:43851621G>A	uc010ggz.2	+	2	1405	c.1348G>A	c.(1348-1350)GTA>ATA	p.V450I	SEMG2_uc002xnk.2_Missense_Mutation_p.V450I|SEMG2_uc002xnl.2_Intron	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	450	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				TCAAAACCAGGTAACAATTCC	0.383													A	43851621	A	A	43851621	3	1	185	1	0	0	0	0	1	0	0	0	14045	1261	44	3	1354	3	SEMG2	20	43851621	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08		43851621	19173899	60	13157											
SULF2	55959	broad.mit.edu	37	chr20	46292214	46292214	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacgtgtccagaaaggcgccGtctgccagtgctggttgtcg	14	12	1	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr20:46292214G>A	uc002xto.2	-	16	2540	c.2210C>T	c.(2209-2211)ACG>ATG	p.T737M	SULF2_uc002xtr.2_Missense_Mutation_p.T737M|SULF2_uc002xtq.2_Missense_Mutation_p.T737M|SULF2_uc010zyd.1_Missense_Mutation_p.T16M	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	737					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GAAAGGCGCCGTCTGCCAGTG	0.597											OREG0026005	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	46292214	A	A	46292214	3	1	185	1	0	0	0	0	1	0	0	0	15370	1145	40	1	426	1	SULF2	20	46292214	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	2440593	46292214	16733306	61	13158											
ZFP64	55734	broad.mit.edu	37	chr20	50803594	50803594	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagtcagctccaccagcacCgttgtgccacctggaactcc	10	16	1	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr20:50803594C>T	uc002xwl.2	-	2	412	c.63G>A	c.(61-63)ACG>ACA	p.T21T	ZFP64_uc002xwk.2_Silent_p.T21T|ZFP64_uc002xwm.2_Silent_p.T19T|ZFP64_uc002xwn.2_Silent_p.T21T	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CCACCAGCACCGTTGTGCCAC	0.483													T	50803594	T	T	50803594	2	4	185	1	0	0	0	0	0	0	0	1	17649	639	23	2		2	ZFP64	20	50803594	Silent	SNP	C	TCGA-27-1833-01A-01W-0643-08	4511380	50803594	12221926	62	13159											
LAMA5	3911	broad.mit.edu	37	chr20	60921843	60921843	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taacagtcggtggcatggccGtagcagttacaggctagaga	14	8	0	1			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr20:60921843G>A	uc002ycq.2	-	8	1153	c.1086C>T	c.(1084-1086)TAC>TAT	p.Y362Y		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	362	Laminin EGF-like 2.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGCATGGCCGTAGCAGTTAC	0.667													A	60921843	A	A	60921843	2	1	185	1	0	0	0	0	0	0	0	1	8609	1140	40	1		1	LAMA5	20	60921843	Silent	SNP	G	TCGA-27-1833-01A-01W-0643-08	10118249	60921843	2103677	63	13160											
TMPRSS15	5651	broad.mit.edu	37	chr21	19770222	19770222	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtaaaactcttgagttcttAtattcattcttcagattgct	5	7	5	2			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr21:19770222A>G	uc002ykw.2	-	3	349	c.318T>C	c.(316-318)TAT>TAC	p.Y106Y		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	106	Extracellular (Potential).|SEA.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TTGAGTTCTTATATTCATTCT	0.249													G	19770222	G	G	19770222	2	3	185	1	0	0	0	0	0	0	0	1	16243	456	16	4		4	TMPRSS15	21	19770222	Silent	SNP	A	TCGA-27-1833-01A-01W-0643-08		19770222	28359673	64	13161											
RIPK4	54101	broad.mit.edu	37	chr21	43161519	43161519	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggtagtgcccgcgctgtgCggccaggtgcaatggcgtcc	17	13	0	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr21:43161519C>T	uc002yzn.1	-	8	1882	c.1834G>A	c.(1834-1836)GCA>ACA	p.A612T		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	612						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						CCGCGCTGTGCGGCCAGGTGC	0.687													T	43161519	T	T	43161519	3	4	185	1	0	0	0	0	1	0	0	0	13383	768	27	1	524	1	RIPK4	21	43161519	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	23391297	43161519	4968376	65	13162											
A4GALT	53947	broad.mit.edu	37	chr22	43089430	43089430	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgagtgcgatcctggaggcGtcggagagcacgggcagcag	18	9	0	2			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr22:43089430G>A	uc003bdb.2	-	3	789	c.528C>T	c.(526-528)GAC>GAT	p.D176D	A4GALT_uc010gzd.2_Silent_p.D176D	NM_017436	NP_059132	Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	176	Lumenal (Potential).				glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			central_nervous_system(2)	2						TCCTGGAGGCGTCGGAGAGCA	0.652													A	43089430	A	A	43089430	2	1	185	1	0	0	0	0	0	0	0	1	6	1136	40	1		1	A4GALT	22	43089430	Silent	SNP	G	TCGA-27-1833-01A-01W-0643-08		43089430	8215136	66	13163											
SHANK3	85358	broad.mit.edu	37	chr22	51159629	51159629	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgagctctggcctcccaggCgccctcccggtcccccacac	10	22	1	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chr22:51159629C>T	uc003bne.1	+	22	3416	c.3416C>T	c.(3415-3417)GCG>GTG	p.A1139V	SHANK3_uc003bnf.1_Missense_Mutation_p.A586V|SHANK3_uc010hbg.1_Missense_Mutation_p.A321V	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1139										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		GCCTCCCAGGCGCCCTCCCGG	0.711													T	51159629	T	T	51159629	3	4	185	1	0	0	0	0	1	0	0	0	14266	768	27	1	3502	1	SHANK3	22	51159629	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	8070199	51159629	144937	67	13164											
MAGEB4	4115	broad.mit.edu	37	chrX	30260469	30260469	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacccaccacctctgctgctGcagctatgtcatgcactgga	8	16	2	0			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chrX:30260469G>A	uc004dcb.2	+	1	301	c.217G>A	c.(217-219)GCA>ACA	p.A73T	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	73										ovary(1)	1						CTCTGCTGCTGCAGCTATGTC	0.527													A	30260469	A	A	30260469	3	1	185	1	0	0	0	0	1	0	0	0	9178	1319	46	3	219	3	MAGEB4	23	30260469	Missense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08		30260469	125010091	68	13165											
CCDC120	90060	broad.mit.edu	37	chrX	48923077	48923077	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatctggggggagccctgagCggcgaaccccatggaaacca	14	12	1	1	rs148446381		TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chrX:48923077C>T	uc010nik.2	+	8	1282	c.775C>T	c.(775-777)CGG>TGG	p.R259W	CCDC120_uc011mmq.1_Missense_Mutation_p.R247W|CCDC120_uc004dmf.2_Missense_Mutation_p.R259W|CCDC120_uc010nil.2_Missense_Mutation_p.R259W|CCDC120_uc011mmr.1_Missense_Mutation_p.R259W|CCDC120_uc011mms.1_Missense_Mutation_p.R247W	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	259							protein binding			pancreas(1)	1						GAGCCCTGAGCGGCGAACCCC	0.642													T	48923077	T	T	48923077	3	4	185	1	0	0	0	0	1	0	0	0	2756	759	27	1	797	1	CCDC120	23	48923077	Missense_Mutation	SNP	C	TCGA-27-1833-01A-01W-0643-08	18662608	48923077	106347483	69	13166											
BRWD3	254065	broad.mit.edu	37	chrX	79938109	79938109	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaaataaggcagataatcGcagcatcatgctatagatct	7	8	3	2			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chrX:79938109G>A	uc004edt.2	-	38	4515	c.4252C>T	c.(4252-4254)CGA>TGA	p.R1418*	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Nonsense_Mutation_p.R1014*|BRWD3_uc004edp.2_Nonsense_Mutation_p.R1247*|BRWD3_uc004edq.2_Nonsense_Mutation_p.R1014*|BRWD3_uc010nmj.1_Nonsense_Mutation_p.R1014*|BRWD3_uc004edr.2_Nonsense_Mutation_p.R1088*|BRWD3_uc004eds.2_Nonsense_Mutation_p.R1014*|BRWD3_uc004edu.2_Nonsense_Mutation_p.R1088*|BRWD3_uc004edv.2_Nonsense_Mutation_p.R1014*|BRWD3_uc004edw.2_Nonsense_Mutation_p.R1014*|BRWD3_uc004edx.2_Nonsense_Mutation_p.R1014*|BRWD3_uc004edy.2_Nonsense_Mutation_p.R1014*|BRWD3_uc004edz.2_Nonsense_Mutation_p.R1088*|BRWD3_uc004eea.2_Nonsense_Mutation_p.R1088*|BRWD3_uc004eeb.2_Nonsense_Mutation_p.R1014*	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1418										ovary(4)	4						GCAGATAATCGCAGCATCATG	0.338													A	79938109	A	A	79938109	4	1	185	1	0	0	0	0	0	1	0	0	1526	1095	38	1	1172	1	BRWD3	23	79938109	Nonsense_Mutation	SNP	G	TCGA-27-1833-01A-01W-0643-08	31015032	79938109	75332451	70	13167											
NXF3	56000	broad.mit.edu	37	chrX	102334798	102334798	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtcatagatcaagtaataCctgttggagaccagtgagga	12	6	2	3			TCGA-27-1833-01A-01W-0643-08	TCGA-27-1833-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	4d8d34d9-7069-436c-84d6-ace5760c2aec	f8e118cf-6937-4ff5-a3d2-77fb32519488	g.chrX:102334798C>T	uc004eju.2	-	13	1124	c.1053G>A	c.(1051-1053)CAG>CAA	p.Q351Q	NXF3_uc010noi.1_Silent_p.Q201Q	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	351	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						TCAAGTAATACCTGTTGGAGA	0.493													T	102334798	T	T	102334798	2	4	185	1	0	0	0	0	0	0	0	1	10785	521	18	3		3	NXF3	23	102334798	Silent	SNP	C	TCGA-27-1833-01A-01W-0643-08	22396689	102334798	52935762	71	13168											
DVL1	1855	broad.mit.edu	37	chr1	1275475	1275475	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gcggccacagccccgcccttCatgatggagccaatgtagat	11	14	1	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr1:1275475C>T	uc001aer.3	-	8	899	c.852G>A	c.(850-852)ATG>ATA	p.M284I	DVL1_uc002quu.2_Missense_Mutation_p.M1I|DVL1_uc009vka.2_5'UTR|DVL1_uc001aeu.1_5'UTR	NM_004421	NP_004412	O14640	DVL1_HUMAN	dishevelled 1	284	PDZ.				canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCCCGCCCTTCATGATGGAGC	0.627													T	1275475	T	T	1275475	3	4	186	1	0	0	0	0	1	0	0	0	4835	826	29	3	1192	3	DVL1	1	1275475	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08		1275475	247975146	1	13169											
AGL	178	broad.mit.edu	37	chr1	100382185	100382185	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctattgggtattttcttcGtgcaaaattatatttttcca	6	7	1	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr1:100382185G>A	uc001dsi.1	+	33	4779	c.4379G>A	c.(4378-4380)CGT>CAT	p.R1460H	AGL_uc001dsj.1_Missense_Mutation_p.R1460H|AGL_uc001dsk.1_Missense_Mutation_p.R1460H|AGL_uc001dsl.1_Missense_Mutation_p.R1460H|AGL_uc001dsm.1_Missense_Mutation_p.R1444H|AGL_uc001dsn.1_Missense_Mutation_p.R1443H	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1460	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TATTTTCTTCGTGCAAAATTA	0.308													A	100382185	A	A	100382185	3	1	186	1	0	0	0	0	1	0	0	0	384	1145	40	1	4574	1	AGL	1	100382185	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	99106710	100382185	148868436	2	13170											
DENND2C	163259	broad.mit.edu	37	chr1	115143493	115143493	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgatggtgcgtccaggaGctgggaaaggagcttccatg	16	8	0	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr1:115143493G>A	uc001efd.1	-	14	2606	c.1904C>T	c.(1903-1905)GCT>GTT	p.A635V	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Missense_Mutation_p.A578V	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	635	DENN.									skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCGTCCAGGAGCTGGGAAAGG	0.448													A	115143493	A	A	115143493	3	1	186	1	0	0	0	0	1	0	0	0	4430	971	34	3	914	3	DENND2C	1	115143493	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	14761308	115143493	134107128	3	13171											
SPAG17	200162	broad.mit.edu	37	chr1	118598400	118598400	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttttgctagcagaagtaagtTtggcattagcagaagatttc	10	5	0	3			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr1:118598400T>A	uc001ehk.2	-	19	2746	c.2678A>T	c.(2677-2679)AAA>ATA	p.K893I		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	893						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AGAAGTAAGTTTGGCATTAGC	0.323													A	118598400	A	A	118598400	3	1	186	1	0	0	0	0	1	0	0	0	14979	1841	64	5	4113	5	SPAG17	1	118598400	Missense_Mutation	SNP	T	TCGA-27-1834-01A-01W-0643-08	3454907	118598400	130652221	4	13172											
FLG	2312	broad.mit.edu	37	chr1	152276824	152276824	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgagtgtctagagctgtccGcctgagtggaagcttcatgg	15	8	2	3	rs143278829	by1000genomes	TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr1:152276824G>A	uc001ezu.1	-	3	10574	c.10538C>T	c.(10537-10539)GCG>GTG	p.A3513V		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3513	Ser-rich.|Filaggrin 21.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGAGCTGTCCGCCTGAGTGGA	0.562									Ichthyosis				A	152276824	A	A	152276824	3	1	186	1	0	0	0	0	1	0	0	0	5922	1087	38	1	1651	1	FLG	1	152276824	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	33678424	152276824	96973797	5	13173											
FLG	2312	broad.mit.edu	37	chr1	152286487	152286487	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctaactctggatcccctaCgctttcttgtcctggactcc	8	15	2	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr1:152286487C>T	uc001ezu.1	-	3	911	c.875G>A	c.(874-876)CGT>CAT	p.R292H	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	292	Filaggrin 1.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGATCCCCTACGCTTTCTTGT	0.502									Ichthyosis				T	152286487	T	T	152286487	3	4	186	1	0	0	0	0	1	0	0	0	5922	536	19	1	11314	1	FLG	1	152286487	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	9663	152286487	96964134	6	13174											
CRNN	49860	broad.mit.edu	37	chr1	152382849	152382849	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctccacagtctgggtggcacCtgcctgggtctgagttccag	13	13	2	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr1:152382849C>A	uc001ezx.2	-	3	783	c.709G>T	c.(709-711)GGT>TGT	p.G237C		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	237	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGGTGGCACCTGCCTGGGTC	0.582													A	152382849	A	A	152382849	3	1	186	1	0	0	0	0	1	0	0	0	3892	681	24	5	782	5	CRNN	1	152382849	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	96362	152382849	96867772	7	13175											
CACNA1E	777	broad.mit.edu	37	chr1	181549749	181549749	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggtattctagaaggatttgAcccccctcacccatgtggtg	10	11	2	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr1:181549749A>T	uc001gow.2	+	6	953	c.788A>T	c.(787-789)GAC>GTC	p.D263V	CACNA1E_uc009wxr.2_Missense_Mutation_p.D170V|CACNA1E_uc009wxs.2_Missense_Mutation_p.D170V	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	263	I.|Extracellular (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GAAGGATTTGACCCCCCTCAC	0.507													T	181549749	T	T	181549749	3	4	186	1	0	0	0	0	1	0	0	0	2542	275	10	5	810	5	CACNA1E	1	181549749	Missense_Mutation	SNP	A	TCGA-27-1834-01A-01W-0643-08	29166900	181549749	67700872	8	13176											
LHCGR	3973	broad.mit.edu	37	chr2	48958384	48958384	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acatttttatgacctcattaAgtcctctgaaagcttgagat	6	8	2	3			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr2:48958384A>T	uc002rwu.3	-	2	285	c.215T>A	c.(214-216)CTT>CAT	p.L72H	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	72	Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GACCTCATTAAGTCCTCTGAA	0.338									Familial_Male-Limited_Precocious_Puberty				T	48958384	T	T	48958384	3	4	186	1	0	0	0	0	1	0	0	0	8762	72	3	5	1924	5	LHCGR	2	48958384	Missense_Mutation	SNP	A	TCGA-27-1834-01A-01W-0643-08		48958384	194240989	9	13177											
TSGA10	80705	broad.mit.edu	37	chr2	99636771	99636771	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttctgccaaacaaaggtgttCtttaagaagctgaatttcag	8	7	3	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr2:99636771C>T	uc002szg.3	-	16	2417	c.1789G>A	c.(1789-1791)GAA>AAA	p.E597K	TSGA10_uc002szh.3_Missense_Mutation_p.E597K|TSGA10_uc002szi.3_Missense_Mutation_p.E597K|TSGA10_uc010fin.1_Missense_Mutation_p.E597K	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	597	Interaction with HIF1A (By similarity).				spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						CAAAGGTGTTCTTTAAGAAGC	0.323													T	99636771	T	T	99636771	3	4	186	1	0	0	0	0	1	0	0	0	16614	922	32	3	323	3	TSGA10	2	99636771	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	50678387	99636771	143562602	10	13178											
GPD2	2820	broad.mit.edu	37	chr2	157439407	157439407	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaagagttccaattccagtgGaccgtagttgtggaggattg	14	6	0	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr2:157439407G>A	uc002tzf.3	+	17	2521	c.2161G>A	c.(2161-2163)GAC>AAC	p.D721N	GPD2_uc010zch.1_Missense_Mutation_p.D494N|GPD2_uc002tzd.3_Missense_Mutation_p.D721N|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	721					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						AATTCCAGTGGACCGTAGTTG	0.443													A	157439407	A	A	157439407	3	1	186	1	0	0	0	0	1	0	0	0	6606	1174	41	3	2223	3	GPD2	2	157439407	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	57802636	157439407	85759966	11	13179											
XIRP2	129446	broad.mit.edu	37	chr2	168098387	168098387	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaagatcctttattctgaCaaagagatgacaaccccagc	7	10	1	4			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr2:168098387C>T	uc002udx.2	+	7	1161	c.1143C>T	c.(1141-1143)GAC>GAT	p.D381D	XIRP2_uc010fpn.2_Silent_p.D414D|XIRP2_uc010fpo.2_Silent_p.D381D|XIRP2_uc010fpp.2_Silent_p.D381D|XIRP2_uc002udy.2_Silent_p.D206D|XIRP2_uc010fpq.2_Silent_p.D159D|XIRP2_uc010fpr.2_Silent_p.D159D	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	206					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTTATTCTGACAAAGAGATGA	0.368													T	168098387	T	T	168098387	2	4	186	1	0	0	0	0	0	0	0	1	17427	477	17	3		3	XIRP2	2	168098387	Silent	SNP	C	TCGA-27-1834-01A-01W-0643-08	10658980	168098387	75100986	12	13180											
ALS2CR8	79800	broad.mit.edu	37	chr2	203846966	203846966	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atagccttcaaagagatacaTgcttaacccaaaacaatagt	5	9	1	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr2:203846966T>C	uc002uzo.2	+	15	2141	c.1861T>C	c.(1861-1863)TGC>CGC	p.C621R	ALS2CR8_uc010zia.1_Missense_Mutation_p.C545R|ALS2CR8_uc010zib.1_Missense_Mutation_p.C545R|ALS2CR8_uc010zic.1_Missense_Mutation_p.C533R|ALS2CR8_uc002uzp.2_Missense_Mutation_p.C621R	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	621										large_intestine(1)|ovary(1)	2						AAGAGATACATGCTTAACCCA	0.418													C	203846966	C	C	203846966	3	2	186	1	0	0	0	0	1	0	0	0	555	1464	51	4	1911	4	ALS2CR8	2	203846966	Missense_Mutation	SNP	T	TCGA-27-1834-01A-01W-0643-08	35748579	203846966	39352407	13	13181											
EPHA4	2043	broad.mit.edu	37	chr2	222428934	222428934	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccttgcaagtccccatgaCgcccggaagactattgcagt	9	14	0	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr2:222428934C>T	uc002vmq.2	-	3	382	c.340G>A	c.(340-342)GTC>ATC	p.V114I	EPHA4_uc002vmr.2_Missense_Mutation_p.V114I|EPHA4_uc010zlm.1_Missense_Mutation_p.V55I|EPHA4_uc010zln.1_Missense_Mutation_p.V114I	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	114	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GTCCCCATGACGCCCGGAAGA	0.453													T	222428934	T	T	222428934	3	4	186	1	0	0	0	0	1	0	0	0	5169	536	19	1	2680	1	EPHA4	2	222428934	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	18581968	222428934	20770439	14	13182											
RPL32	6161	broad.mit.edu	37	chr3	12881707	12881707	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttctctttttgacgatcttGggcttcacaaggggtctgag	12	8	4	2	rs144517633		TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr3:12881707G>A	uc003bxl.2	-	1	243	c.30C>T	c.(28-30)CCC>CCT	p.P10P	RPL32_uc003bxm.2_Silent_p.P10P|RPL32_uc003bxn.2_Silent_p.P10P	NM_001007074	NP_001007075	P62910	RL32_HUMAN	ribosomal protein L32	10					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome			ovary(1)	1						TGACGATCTTGGGCTTCACAA	0.537													A	12881707	A	A	12881707	2	1	186	1	0	0	0	0	0	0	0	1	13582	1335	47	3		3	RPL32	3	12881707	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08		12881707	185140723	15	13183											
CELSR3	1951	broad.mit.edu	37	chr3	48697393	48697393	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctccaggagataggtgataCgagcattctcacccacgtca	9	13	2	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr3:48697393C>T	uc003cul.2	-	1	2956	c.2675G>A	c.(2674-2676)CGT>CAT	p.R892H	CELSR3_uc003cuf.1_Missense_Mutation_p.R962H	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	892	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATAGGTGATACGAGCATTCTC	0.363													T	48697393	T	T	48697393	3	4	186	1	0	0	0	0	1	0	0	0	3223	536	19	1	7403	1	CELSR3	3	48697393	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	35815686	48697393	149325037	16	13184											
MYH15	22989	broad.mit.edu	37	chr3	108189636	108189636	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccctgttgatccgtgccactAgccacttaaacatcctttca	5	15	1	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr3:108189636A>G	uc003dxa.1	-	14	1409	c.1352T>C	c.(1351-1353)CTA>CCA	p.L451P		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	451	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CCGTGCCACTAGCCACTTAAA	0.458													G	108189636	G	G	108189636	3	3	186	1	0	0	0	0	1	0	0	0	10034	420	15	4	4604	4	MYH15	3	108189636	Missense_Mutation	SNP	A	TCGA-27-1834-01A-01W-0643-08	59492243	108189636	89832794	17	13185											
PHLDB2	90102	broad.mit.edu	37	chr3	111604066	111604066	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagtttttgcgaccaggaGgaacttctcttgtggatctg	12	8	2	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr3:111604066G>A	uc010hqa.2	+	2	1553	c.1142G>A	c.(1141-1143)AGG>AAG	p.R381K	PHLDB2_uc003dyc.2_Missense_Mutation_p.R408K|PHLDB2_uc003dyd.2_Missense_Mutation_p.R381K|PHLDB2_uc003dyg.2_Missense_Mutation_p.R381K|PHLDB2_uc003dyh.2_Missense_Mutation_p.R381K|PHLDB2_uc003dye.3_Missense_Mutation_p.R381K|PHLDB2_uc003dyf.3_Missense_Mutation_p.R381K	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	381						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GCGACCAGGAGGAACTTCTCT	0.517													A	111604066	A	A	111604066	3	1	186	1	0	0	0	0	1	0	0	0	11852	1000	35	3	1229	3	PHLDB2	3	111604066	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	3414430	111604066	86418364	18	13186											
EPHB1	2047	broad.mit.edu	37	chr3	134920351	134920351	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttcaccgtgatccagcttgtGggtatgctcaggggcatcgc	13	11	2	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr3:134920351G>T	uc003eqt.2	+	12	2386	c.2166G>T	c.(2164-2166)GTG>GTT	p.V722V	EPHB1_uc003equ.2_Silent_p.V283V	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	722	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TCCAGCTTGTGGGTATGCTCA	0.507													T	134920351	T	T	134920351	2	4	186	1	0	0	0	0	0	0	0	1	5174	1335	47	5		5	EPHB1	3	134920351	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08	23316285	134920351	63102079	19	13187											
PRR23C	389152	broad.mit.edu	37	chr3	138763141	138763141	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctcctgagcattcgtcgaCggagctcaggaggacctcgg	14	13	1	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr3:138763141C>T	uc011bmt.1	-	1	594	c.322G>A	c.(322-324)GTC>ATC	p.V108I		NM_001134657	NP_001128129	Q6ZRP0	PR23C_HUMAN	proline rich 23C	108										skin(1)	1						CATTCGTCGACGGAGCTCAGG	0.642													T	138763141	T	T	138763141	3	4	186	1	0	0	0	0	1	0	0	0	12596	536	19	1	470	1	PRR23C	3	138763141	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	3842790	138763141	59259289	20	13188											
MBNL1	4154	broad.mit.edu	37	chr3	152018056	152018056	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtagagagttccagagggGgacttgctcacggccagaca	14	9	1	3			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr3:152018056G>A	uc003ezm.2	+	1	863	c.74G>A	c.(73-75)GGG>GAG	p.G25E	MBNL1_uc003ezh.2_Missense_Mutation_p.G25E|MBNL1_uc003ezi.2_Missense_Mutation_p.G25E|MBNL1_uc003ezj.2_Intron|MBNL1_uc003ezl.2_Missense_Mutation_p.G25E|MBNL1_uc003ezp.2_Missense_Mutation_p.G25E|MBNL1_uc003ezn.2_Missense_Mutation_p.G25E|MBNL1_uc003ezo.2_Missense_Mutation_p.G25E|MBNL1_uc003ezg.1_RNA|MBNL1_uc003ezk.1_RNA	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	muscleblind-like 1 isoform c	25	C3H1-type 1.				embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TTCCAGAGGGGGACTTGCTCA	0.428													A	152018056	A	A	152018056	3	1	186	1	0	0	0	0	1	0	0	0	9353	1232	43	3	76	3	MBNL1	3	152018056	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	13254915	152018056	46004374	21	13189											
MBNL1	4154	broad.mit.edu	37	chr3	152132751	152132751	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gccgttgctccagggagaacTgcaaatatcttcatccaccc	8	14	2	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr3:152132751T>A	uc003ezm.2	+	2	985	c.196T>A	c.(196-198)TGC>AGC	p.C66S	MBNL1_uc003ezh.2_Missense_Mutation_p.C66S|MBNL1_uc003ezi.2_Missense_Mutation_p.C66S|MBNL1_uc003ezj.2_Missense_Mutation_p.C9S|MBNL1_uc003ezl.2_Missense_Mutation_p.C66S|MBNL1_uc003ezp.2_Missense_Mutation_p.C66S|MBNL1_uc003ezn.2_Missense_Mutation_p.C66S|MBNL1_uc003ezo.2_Missense_Mutation_p.C66S|MBNL1_uc010hvp.2_5'UTR	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	muscleblind-like 1 isoform c	66	C3H1-type 2.				embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CAGGGAGAACTGCAAATATCT	0.393													A	152132751	A	A	152132751	3	1	186	1	0	0	0	0	1	0	0	0	9353	1580	55	5	202	5	MBNL1	3	152132751	Missense_Mutation	SNP	T	TCGA-27-1834-01A-01W-0643-08	114695	152132751	45889679	22	13190											
ALG3	10195	broad.mit.edu	37	chr3	183960423	183960423	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctgcaggatgtggaagggTatgtgttccaggagagctcg	17	6	0	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr3:183960423T>G	uc003fne.2	-	9	1227	c.1196A>C	c.(1195-1197)TAC>TCC	p.Y399S	ALG3_uc011brc.1_Missense_Mutation_p.Y364S|ALG3_uc011brd.1_Missense_Mutation_p.Y343S|ALG3_uc011bre.1_Missense_Mutation_p.Y351S	NM_005787	NP_005778	Q92685	ALG3_HUMAN	alpha-1,3-mannosyltransferase ALG3 isoform a	399					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity				0	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGTGGAAGGGTATGTGTTCCA	0.587													G	183960423	G	G	183960423	3	3	186	1	0	0	0	0	1	0	0	0	520	1638	57	5	124	5	ALG3	3	183960423	Missense_Mutation	SNP	T	TCGA-27-1834-01A-01W-0643-08	31827672	183960423	14062007	23	13191											
FRAS1	80144	broad.mit.edu	37	chr4	79400664	79400664	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgagtcgtgtgatattcggGcctggtgtgaccatgtccac	14	10	0	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr4:79400664G>A	uc003hlb.2	+	56	8675	c.8235G>A	c.(8233-8235)GGG>GGA	p.G2745G		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2740	Extracellular (Potential).|Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGATATTCGGGCCTGGTGTGA	0.483													A	79400664	A	A	79400664	2	1	186	1	0	0	0	0	0	0	0	1	6042	1190	42	3		3	FRAS1	4	79400664	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08		79400664	111753612	24	13192											
ENPEP	2028	broad.mit.edu	37	chr4	111474494	111474494	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggatttgctcaaggacaCgaaccttattaaaactcagg	8	8	2	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr4:111474494C>T	uc003iab.3	+	18	2867	c.2525C>T	c.(2524-2526)ACG>ATG	p.T842M		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	842	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CTCAAGGACACGAACCTTATT	0.353													T	111474494	T	T	111474494	3	4	186	1	0	0	0	0	1	0	0	0	5128	536	19	1	2595	1	ENPEP	4	111474494	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	32073830	111474494	79679782	25	13193											
NR3C2	4306	broad.mit.edu	37	chr4	149357361	149357361	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaaaactgccaaagctggCtgtggtggaggacacagagt	15	7	0	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr4:149357361C>T	uc003ilj.3	-	2	986	c.652G>A	c.(652-654)GCC>ACC	p.A218T	NR3C2_uc003ilk.3_Missense_Mutation_p.A218T|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	218	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	CCAAAGCTGGCTGTGGTGGAG	0.532													T	149357361	T	T	149357361	3	4	186	1	0	0	0	0	1	0	0	0	10631	797	28	3	2334	3	NR3C2	4	149357361	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	37882867	149357361	41796915	26	13194											
SOX30	11063	broad.mit.edu	37	chr5	157078493	157078493	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgggcttttgcctgccccGccttgcatcgagtctctcat	10	16	2	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr5:157078493G>A	uc003lxb.1	-	1	936	c.594C>T	c.(592-594)GGC>GGT	p.G198G	SOX30_uc003lxc.1_Silent_p.G198G|SOX30_uc011dds.1_Intron	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	198					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGCCTGCCCCGCCTTGCATCG	0.657													A	157078493	A	A	157078493	2	1	186	1	0	0	0	0	0	0	0	1	14952	1074	38	1		1	SOX30	5	157078493	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08		157078493	23836767	27	13195											
DDR1	780	broad.mit.edu	37	chr6	30861171	30861171	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcattgccctcatgctctggCggctgcactggcgcaggctc	12	15	3	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr6:30861171C>T	uc003nrr.2	+	11	1577	c.1318C>T	c.(1318-1320)CGG>TGG	p.R440W	DDR1_uc010jse.2_Missense_Mutation_p.R440W|DDR1_uc003nrq.2_Missense_Mutation_p.R440W|DDR1_uc003nrs.2_Missense_Mutation_p.R440W|DDR1_uc003nrt.2_Missense_Mutation_p.R440W|DDR1_uc011dms.1_Missense_Mutation_p.R458W|DDR1_uc003nru.2_Missense_Mutation_p.R440W|DDR1_uc003nrv.2_Missense_Mutation_p.R440W|DDR1_uc003nrw.1_Missense_Mutation_p.R239W|DDR1_uc003nry.1_RNA|DDR1_uc003nrx.1_RNA	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	440	Helical; (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	CATGCTCTGGCGGCTGCACTG	0.697													T	30861171	T	T	30861171	3	4	186	1	0	0	0	0	1	0	0	0	4336	759	27	1	1352	1	DDR1	6	30861171	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08		30861171	140253896	28	13196											
THSD7A	221981	broad.mit.edu	37	chr7	11514021	11514021	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgacttttcttgtctgcatgCcgacagagcaggaggcctcc	11	12	2	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr7:11514021C>T	uc003ssf.3	-	8	2444	c.2192G>A	c.(2191-2193)GGC>GAC	p.G731D		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	731	TSP type-1 7.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TGTCTGCATGCCGACAGAGCA	0.512										HNSCC(18;0.044)			T	11514021	T	T	11514021	3	4	186	1	0	0	0	0	1	0	0	0	15876	739	26	3	2861	3	THSD7A	7	11514021	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08		11514021	147624642	29	13197											
IGF2BP3	10643	broad.mit.edu	37	chr7	23509595	23509595	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgagggcccagctctcgtcCgggcagtccacgaacgcgta	13	14	1	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr7:23509595C>T	uc003swg.2	-	1	401	c.135G>A	c.(133-135)CCG>CCA	p.P45P	IGF2BP3_uc003swh.1_RNA	NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	45	RRM 1.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						AGCTCTCGTCCGGGCAGTCCA	0.697													T	23509595	T	T	23509595	2	4	186	1	0	0	0	0	0	0	0	1	7575	639	23	2		2	IGF2BP3	7	23509595	Silent	SNP	C	TCGA-27-1834-01A-01W-0643-08	11995574	23509595	135629068	30	13198											
GNAT3	346562	broad.mit.edu	37	chr7	80117947	80117947	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttactgtaaattactgctttGaactccatgcattcttgctc	5	10	1	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr7:80117947G>A	uc011kgu.1	-	3	207	c.207C>T	c.(205-207)TTC>TTT	p.F69F	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	69					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TTACTGCTTTGAACTCCATGC	0.338													A	80117947	A	A	80117947	2	1	186	1	0	0	0	0	0	0	0	1	6513	1281	45	3		3	GNAT3	7	80117947	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08	56608352	80117947	79020716	31	13199											
TRRAP	8295	broad.mit.edu	37	chr7	98554147	98554147	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttaggacggccaccggagcCatcagtgcagtaagatcatg	12	10	2	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr7:98554147C>T	uc003upp.2	+	42	6410	c.6201C>T	c.(6199-6201)GCC>GCT	p.A2067A	TRRAP_uc011kis.1_Silent_p.A2049A|TRRAP_uc003upr.2_Silent_p.A1766A	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2067	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCACCGGAGCCATCAGTGCAG	0.512													T	98554147	T	T	98554147	2	4	186	1	0	0	0	0	0	0	0	1	16598	581	21	3		3	TRRAP	7	98554147	Silent	SNP	C	TCGA-27-1834-01A-01W-0643-08	18436200	98554147	60584516	32	13200											
TRRAP	8295	broad.mit.edu	37	chr7	98567836	98567836	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcaacctggccgatagccaCgaccgtgccgccttcgccat	9	17	1	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr7:98567836C>T	uc003upp.2	+	51	7802	c.7593C>T	c.(7591-7593)CAC>CAT	p.H2531H	TRRAP_uc011kis.1_Silent_p.H2513H|TRRAP_uc003upr.2_Silent_p.H2230H	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2531					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCGATAGCCACGACCGTGCCG	0.632													T	98567836	T	T	98567836	2	4	186	1	0	0	0	0	0	0	0	1	16598	535	19	1		1	TRRAP	7	98567836	Silent	SNP	C	TCGA-27-1834-01A-01W-0643-08	13689	98567836	60570827	33	13201											
CLCN1	1180	broad.mit.edu	37	chr7	143043325	143043325	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggccacaaacagcagccGgaagcaccagagcctgcagg	12	15	0	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr7:143043325G>A	uc003wcr.1	+	18	2352	c.2265G>A	c.(2263-2265)CCG>CCA	p.P755P	CLCN1_uc011ktc.1_Silent_p.P367P	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	755	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					AACAGCAGCCGGAAGCACCAG	0.602													A	143043325	A	A	143043325	2	1	186	1	0	0	0	0	0	0	0	1	3462	1103	39	2		2	CLCN1	7	143043325	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08	44475489	143043325	16095338	34	13202											
OR6B1	135946	broad.mit.edu	37	chr7	143701705	143701705	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actttatcctggcactggtcAtcttcctattcccactcttt	4	14	3	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr7:143701705A>G	uc003wdt.1	+	1	616	c.616A>G	c.(616-618)ATC>GTC	p.I206V		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					GGCACTGGTCATCTTCCTATT	0.458													G	143701705	G	G	143701705	3	3	186	1	0	0	0	0	1	0	0	0	11187	217	8	4	618	4	OR6B1	7	143701705	Missense_Mutation	SNP	A	TCGA-27-1834-01A-01W-0643-08	658380	143701705	15436958	35	13203											
HR	55806	broad.mit.edu	37	chr8	21983183	21983183	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttgagccagttttgcagggaGagccaggcatggtatgtcct	14	8	0	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr8:21983183G>T	uc003xas.2	-	4	2133	c.1468C>A	c.(1468-1470)CTC>ATC	p.L490I	HR_uc003xat.2_Missense_Mutation_p.L490I	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	490							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		TTTGCAGGGAGAGCCAGGCAT	0.602													T	21983183	T	T	21983183	3	4	186	1	0	0	0	0	1	0	0	0	7347	942	33	5	2165	5	HR	8	21983183	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08		21983183	124380839	36	13204											
CYP11B2	1585	broad.mit.edu	37	chr8	143994857	143994857	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaagagcgtcatcagcaagGgaaacgctgtctacagaagc	11	10	3	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr8:143994857G>A	uc003yxk.1	-	6	968	c.965C>T	c.(964-966)CCC>CTC	p.P322L		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	322					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CATCAGCAAGGGAAACGCTGT	0.632									Familial_Hyperaldosteronism_type_I				A	143994857	A	A	143994857	3	1	186	1	0	0	0	0	1	0	0	0	4146	1232	43	3	562	3	CYP11B2	8	143994857	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	122011674	143994857	2369165	37	13205											
IFNB1	3456	broad.mit.edu	37	chr9	21077465	21077465	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gcagactgctcatgagttttCccctggtgaaatcttctttc	8	11	3	3			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr9:21077465C>A	uc003zok.2	-	1	479	c.404G>T	c.(403-405)GGA>GTA	p.G135V		NM_002176	NP_002167	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast precursor	135					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			ovary(1)|breast(1)|kidney(1)	3				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)	CATGAGTTTTCCCCTGGTGAA	0.443													A	21077465	A	A	21077465	3	1	186	1	0	0	0	0	1	0	0	0	7546	855	30	5	163	5	IFNB1	9	21077465	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08		21077465	120135966	38	13206											
OR1J4	26219	broad.mit.edu	37	chr9	125281885	125281885	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatcctctcctgtaccaatGccctgtctcacactctcctc	5	18	3	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr9:125281885G>A	uc011lyw.1	+	1	466	c.466G>A	c.(466-468)GCC>ACC	p.A156T		NM_001004452	NP_001004452	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGTACCAATGCCCTGTCTCA	0.517													A	125281885	A	A	125281885	3	1	186	1	0	0	0	0	1	0	0	0	10961	1319	46	3	468	3	OR1J4	9	125281885	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	104204420	125281885	15931546	39	13207											
GTF3C4	9329	broad.mit.edu	37	chr9	135546145	135546145	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgcctcatggtgactcggCgggagccggccgtgaagctg	16	13	1	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr9:135546145C>T	uc010mzv.2	+	1	418	c.160C>T	c.(160-162)CGG>TGG	p.R54W	DDX31_uc004cbq.1_5'Flank|DDX31_uc010mzu.1_5'Flank|DDX31_uc004cbr.1_5'Flank|DDX31_uc004cbs.1_5'Flank|GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	54					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GGTGACTCGGCGGGAGCCGGC	0.567													T	135546145	T	T	135546145	3	4	186	1	0	0	0	0	1	0	0	0	6875	759	27	1	162	1	GTF3C4	9	135546145	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	10264260	135546145	5667286	40	13208											
C9orf116	138162	broad.mit.edu	37	chr9	138387358	138387358	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatgcagttatcggggccaGtcacgatgcttttctccagg	12	10	2	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr9:138387358G>A	uc004cft.1	-	3	390	c.326C>T	c.(325-327)ACT>ATT	p.T109I	C9orf116_uc004cfs.1_3'UTR|C9orf116_uc004cfu.1_RNA	NM_001048265	NP_001041730	Q5BN46	CI116_HUMAN	hypothetical protein LOC138162 isoform 1	109											0				OV - Ovarian serous cystadenocarcinoma(145;7.39e-08)|Epithelial(140;5.19e-07)|all cancers(34;1.04e-05)		ATCGGGGCCAGTCACGATGCT	0.478													A	138387358	A	A	138387358	3	1	186	1	0	0	0	0	1	0	0	0	2450	1029	36	3	88	3	C9orf116	9	138387358	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	2841213	138387358	2826073	41	13209											
FAM107B	83641	broad.mit.edu	37	chr10	14564008	14564008	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	caattctggtttgttctgagGagcaagacccctgcgaaaga	11	9	2	3			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr10:14564008G>C	uc001imx.1	-	3	384	c.139C>G	c.(139-141)CCT>GCT	p.P47A	FAM107B_uc001ina.1_Missense_Mutation_p.P222A|FAM107B_uc010qbu.1_RNA|FAM107B_uc009xjg.1_Missense_Mutation_p.P47A|FAM107B_uc001imy.1_Missense_Mutation_p.P47A|FAM107B_uc001imz.1_Missense_Mutation_p.P47A	NM_031453	NP_113641	Q9H098	F107B_HUMAN	hypothetical protein LOC83641	47										breast(4)	4						TTGTTCTGAGGAGCAAGACCC	0.358													C	14564008	C	C	14564008	3	2	186	1	0	0	0	0	1	0	0	0	5390	1174	41	5	264	5	FAM107B	10	14564008	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08		14564008	120970739	42	13210											
PARD3	56288	broad.mit.edu	37	chr10	34663908	34663908	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caacttcctcttgggatttgCccactaaatctactccattt	4	13	2	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr10:34663908C>T	uc010qej.1	-	11	1562	c.1562G>A	c.(1561-1563)GGC>GAC	p.G521D	PARD3_uc010qek.1_Missense_Mutation_p.G521D|PARD3_uc010qel.1_Missense_Mutation_p.G521D|PARD3_uc010qem.1_Missense_Mutation_p.G521D|PARD3_uc010qen.1_Missense_Mutation_p.G521D|PARD3_uc010qeo.1_Missense_Mutation_p.G521D|PARD3_uc010qep.1_Missense_Mutation_p.G477D|PARD3_uc010qeq.1_Missense_Mutation_p.G477D|PARD3_uc001ixo.1_Missense_Mutation_p.G251D|PARD3_uc001ixp.1_Missense_Mutation_p.G386D|PARD3_uc001ixq.1_Missense_Mutation_p.G521D|PARD3_uc001ixr.1_Missense_Mutation_p.G521D|PARD3_uc001ixt.1_Missense_Mutation_p.G342D|PARD3_uc001ixu.1_Missense_Mutation_p.G477D|PARD3_uc001ixs.1_Missense_Mutation_p.G174D	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	521	PDZ 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				TTGGGATTTGCCCACTAAATC	0.388													T	34663908	T	T	34663908	3	4	186	1	0	0	0	0	1	0	0	0	11443	739	26	3	2603	3	PARD3	10	34663908	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	20099900	34663908	100870839	43	13211											
PTEN	5728	broad.mit.edu	37	chr10	89720676	89720676	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatgtttcacttttgggtaaAtacattcttcataccaggac	6	8	3	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr10:89720676A>G	uc001kfb.2	+	9	1858	c.827A>G	c.(826-828)AAT>AGT	p.N276S		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	276	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.D268_F279>VGQNVSLLGKYI(2)|p.N276fs*15(2)|p.G165_*404del(1)|p.G165_K342del(1)|p.W274_F341del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTTTGGGTAAATACATTCTTC	0.254		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			G	89720676	G	G	89720676	3	3	186	1	0	0	0	0	1	0	0	0	12738	101	4	4	857	4	PTEN	10	89720676	Missense_Mutation	SNP	A	TCGA-27-1834-01A-01W-0643-08	55056768	89720676	45814071	44	13212											
DNMBP	23268	broad.mit.edu	37	chr10	101715528	101715528	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtaaaattttatctggctctGtgccgggccctgccaagctc	10	12	2	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr10:101715528G>C	uc001kqj.2	-	4	1795	c.1703C>G	c.(1702-1704)ACA>AGA	p.T568R	NCRNA00093_uc001kqk.1_RNA	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	568					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		ATCTGGCTCTGTGCCGGGCCC	0.498													C	101715528	C	C	101715528	3	2	186	1	0	0	0	0	1	0	0	0	4674	1377	48	5	3086	5	DNMBP	10	101715528	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08	11994852	101715528	33819219	45	13213											
NELL1	4745	broad.mit.edu	37	chr11	21135236	21135236	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	actgtgtcccaggatacattCgtgtggatgacttctcttgt	10	9	1	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr11:21135236C>T	uc001mqe.2	+	13	1555	c.1402C>T	c.(1402-1404)CGT>TGT	p.R468C	NELL1_uc001mqf.2_Missense_Mutation_p.R468C|NELL1_uc009yid.2_Missense_Mutation_p.R496C|NELL1_uc010rdo.1_Missense_Mutation_p.R411C|NELL1_uc010rdp.1_Missense_Mutation_p.R228C	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	468	EGF-like 2; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						AGGATACATTCGTGTGGATGA	0.403													T	21135236	T	T	21135236	3	4	186	1	0	0	0	0	1	0	0	0	10333	884	31	2	1452	2	NELL1	11	21135236	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08		21135236	113871280	46	13214											
OR5M8	219484	broad.mit.edu	37	chr11	56258155	56258155	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaaaagctttttgcctgcccTctgtagagcgaatctttaaa	7	9	2	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr11:56258155T>A	uc001nix.1	-	1	692	c.692A>T	c.(691-693)GAG>GTG	p.E231V		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					TTGCCTGCCCTCTGTAGAGCG	0.413													A	56258155	A	A	56258155	3	1	186	1	0	0	0	0	1	0	0	0	11176	1551	54	5	247	5	OR5M8	11	56258155	Missense_Mutation	SNP	T	TCGA-27-1834-01A-01W-0643-08	35122919	56258155	78748361	47	13215											
MS4A4A	51338	broad.mit.edu	37	chr11	60075609	60075609	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attctgccatcacattctcaCatggcagaaacagcatctcc	5	14	4	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr11:60075609C>T	uc001noz.2	+	7	688	c.678C>T	c.(676-678)CAC>CAT	p.H226H	MS4A4A_uc001npa.2_Silent_p.H207H|MS4A4A_uc001npb.2_Silent_p.H207H|MS4A4A_uc001npc.2_Silent_p.H154H	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	226	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						CACATTCTCACATGGCAGAAA	0.458													T	60075609	T	T	60075609	2	4	186	1	0	0	0	0	0	0	0	1	9862	477	17	3		3	MS4A4A	11	60075609	Silent	SNP	C	TCGA-27-1834-01A-01W-0643-08	3817454	60075609	74930907	48	13216											
CCDC87	55231	broad.mit.edu	37	chr11	66359836	66359836	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttagagcactgcacttgggcGaagccagtgctgtgaggcca	14	10	0	2	rs17853294		TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr11:66359836G>A	uc001oiq.3	-	1	719	c.651C>T	c.(649-651)TTC>TTT	p.F217F	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	217										ovary(1)|skin(1)	2						GCACTTGGGCGAAGCCAGTGC	0.592													A	66359836	A	A	66359836	2	1	186	1	0	0	0	0	0	0	0	1	2862	1049	37	2		2	CCDC87	11	66359836	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08	6284227	66359836	68646680	49	13217											
CNTN5	53942	broad.mit.edu	37	chr11	99827702	99827703	+	Frame_Shift_Ins	INS	-	TCCTTAGTCC	TCCTTAGTCC													cacagtgacgaatgctagagINStccttagtcctccaacgcca							TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr11:99827702_99827703insTCCTTAGTCC	uc001pga.2	+	8	1177_1178	c.838_839insTCCTTAGTCC	c.(838-840)GTCfs	p.V280fs	CNTN5_uc009ywv.1_Frame_Shift_Ins_p.V280fs|CNTN5_uc001pfz.2_Frame_Shift_Ins_p.V280fs|CNTN5_uc001pgb.2_Frame_Shift_Ins_p.V206fs	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	280	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GAATGCTAGAGTCCTTAGTCCT	0.416													TCCTTAGTCC	99827703	TCCTTAGTCC	TCCTTAGTCC	99827702	7	5	186	1	0	1	1	0	0	0	0	0	3644	1029	36	0	860	0	CNTN5	11	99827702	Frame_Shift_Ins	INS	-	TCGA-27-1834-01A-01W-0643-08	33467866	99827702	35178814	50	13218											
OPCML	4978	broad.mit.edu	37	chr11	132527102	132527102	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gatgctgtactgggttggtgTattgaccaggatgatcacac	13	7	1	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr11:132527102T>A	uc001qgs.2	-	2	330	c.280A>T	c.(280-282)ACA>TCA	p.T94S	OPCML_uc001qgu.2_Missense_Mutation_p.T87S|OPCML_uc010sck.1_Missense_Mutation_p.T94S|OPCML_uc001qgt.2_Missense_Mutation_p.T94S|OPCML_uc010scl.1_Missense_Mutation_p.T53S	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	94	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TGGGTTGGTGTATTGACCAGG	0.532													A	132527102	A	A	132527102	3	1	186	1	0	0	0	0	1	0	0	0	10874	1638	57	5	781	5	OPCML	11	132527102	Missense_Mutation	SNP	T	TCGA-27-1834-01A-01W-0643-08	32699400	132527102	2479414	51	13219											
MVK	4598	broad.mit.edu	37	chr12	110023885	110023885	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttccaaggggagagaatgAttcacgggaacccctccgga	12	12	1	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr12:110023885A>G	uc001toy.3	+	6	770	c.586A>G	c.(586-588)ATT>GTT	p.I196V	MVK_uc009zvk.2_Missense_Mutation_p.I196V|MVK_uc010sxr.1_Missense_Mutation_p.I144V|MVK_uc001toz.3_Missense_Mutation_p.I2V|MVK_uc001tpc.3_RNA	NM_001114185	NP_001107657	Q03426	KIME_HUMAN	mevalonate kinase	196					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity				0						GGAGAGAATGATTCACGGGAA	0.453													G	110023885	G	G	110023885	3	3	186	1	0	0	0	0	1	0	0	0	9995	333	12	4	604	4	MVK	12	110023885	Missense_Mutation	SNP	A	TCGA-27-1834-01A-01W-0643-08		110023885	23828010	52	13220											
FZD10	11211	broad.mit.edu	37	chr12	130647861	130647861	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cccgattatggagcagttcaActtcaagtggcccgactccc	9	14	2	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr12:130647861A>T	uc001uii.2	+	1	830	c.374A>T	c.(373-375)AAC>ATC	p.N125I	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	125	FZ.|Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GAGCAGTTCAACTTCAAGTGG	0.642													T	130647861	T	T	130647861	3	4	186	1	0	0	0	0	1	0	0	0	6129	43	2	5	376	5	FZD10	12	130647861	Missense_Mutation	SNP	A	TCGA-27-1834-01A-01W-0643-08	20623976	130647861	3204034	53	13221											
OLFM4	10562	broad.mit.edu	37	chr13	53624555	53624555	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gatgagaatggattgtgggtTatttattcaactgaagccag	12	4	1	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr13:53624555T>A	uc001vhl.2	+	5	1182	c.1182T>A	c.(1180-1182)GTT>GTA	p.V394V	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	394	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GATTGTGGGTTATTTATTCAA	0.398													A	53624555	A	A	53624555	2	1	186	1	0	0	0	0	0	0	0	1	10855	1741	61	5		5	OLFM4	13	53624555	Silent	SNP	T	TCGA-27-1834-01A-01W-0643-08		53624555	61545323	54	13222											
OR10G2	26534	broad.mit.edu	37	chr14	22102705	22102705	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagccacacagccaccaaaCgggatagccttgatggaagg	12	11	0	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr14:22102705C>T	uc010tmc.1	-	1	294	c.294G>A	c.(292-294)CCG>CCA	p.P98P		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		AGCCACCAAACGGGATAGCCT	0.493													T	22102705	T	T	22102705	2	4	186	1	0	0	0	0	0	0	0	1	10899	523	19	1		1	OR10G2	14	22102705	Silent	SNP	C	TCGA-27-1834-01A-01W-0643-08		22102705	85246835	55	13223											
FOXA1	3169	broad.mit.edu	37	chr14	38060669	38060669	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggtggtcaccgaggcgctGcctagaggcaggctggcggg	19	11	1	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr14:38060669G>A	uc001wuf.2	-	2	1632	c.1320C>T	c.(1318-1320)GGC>GGT	p.G440G	FOXA1_uc010tpz.1_Silent_p.G407G	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	440					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		CCGAGGCGCTGCCTAGAGGCA	0.607													A	38060669	A	A	38060669	2	1	186	1	0	0	0	0	0	0	0	1	5989	1306	46	3		3	FOXA1	14	38060669	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08	15957964	38060669	69288871	56	13224											
ZNF839	55778	broad.mit.edu	37	chr14	102792551	102792551	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtgacttatgccaacctcCtgctcaggggtttgtacaga	10	10	1	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr14:102792551C>T	uc001ylo.2	+	2	520	c.170C>T	c.(169-171)CCT>CTT	p.P57L	ZNF839_uc010awk.1_Missense_Mutation_p.P173L|ZNF839_uc001ylp.2_RNA|ZNF839_uc001ylq.1_Missense_Mutation_p.P57L|ZNF839_uc001ylr.2_Missense_Mutation_p.P57L	NM_018335	NP_060805	A8K0R7	ZN839_HUMAN	zinc finger protein 839	57						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						TGCCAACCTCCTGCTCAGGGG	0.597													T	102792551	T	T	102792551	3	4	186	1	0	0	0	0	1	0	0	0	18185	681	24	3	524	3	ZNF839	14	102792551	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	64731882	102792551	4556989	57	13225											
ANKS4B	257629	broad.mit.edu	37	chr16	21261689	21261689	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	accatgaatccattctcaatCgtccaggtctaggaagtatt	7	10	2	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr16:21261689C>T	uc010bwp.1	+	2	845	c.802C>T	c.(802-804)CGT>TGT	p.R268C	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	268										ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		CATTCTCAATCGTCCAGGTCT	0.468													T	21261689	T	T	21261689	3	4	186	1	0	0	0	0	1	0	0	0	691	884	31	2	808	2	ANKS4B	16	21261689	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08		21261689	69093064	58	13226											
PRKCB	5579	broad.mit.edu	37	chr16	24185839	24185839	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttttttttttttaatttcagAttttacgctgcagaaattgc	5	5	1	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr16:24185839A>T	uc002dmd.2	+	12	1529	c.1332A>T	c.(1330-1332)GTA>GTT	p.V444V	PRKCB_uc002dme.2_Silent_p.V444V	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	444	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TTAATTTCAGATTTTACGCTG	0.383													T	24185839	T	T	24185839	2	4	186	1	0	0	0	0	0	0	0	1	12508	347	12	5		5	PRKCB	16	24185839	Silent	SNP	A	TCGA-27-1834-01A-01W-0643-08	2924150	24185839	66168914	59	13227											
CHD9	80205	broad.mit.edu	37	chr16	53337839	53337839	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagggatttgcttattggtgCtgccaaacacggggtgagcc	14	8	0	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr16:53337839C>T	uc002ehb.2	+	30	6085	c.5921C>T	c.(5920-5922)GCT>GTT	p.A1974V	CHD9_uc002egy.2_Missense_Mutation_p.A1974V|CHD9_uc002ehc.2_Missense_Mutation_p.A1974V|CHD9_uc002ehf.2_Missense_Mutation_p.A1088V|CHD9_uc010cbw.2_Intron|CHD9_uc002ehg.1_5'UTR	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1974					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CTTATTGGTGCTGCCAAACAC	0.468													T	53337839	T	T	53337839	3	4	186	1	0	0	0	0	1	0	0	0	3332	797	28	3	6039	3	CHD9	16	53337839	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08	29152000	53337839	37016914	60	13228											
SEZ6	124925	broad.mit.edu	37	chr17	27308674	27308674	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgtgattcgaagcatagGggactctgactccggactcc	12	11	1	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr17:27308674G>A	uc002hdp.2	-	2	633	c.439C>T	c.(439-441)CCT>TCT	p.P147S	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.P147S|SEZ6_uc002hdq.1_Missense_Mutation_p.P22S|SEZ6_uc010crz.1_Missense_Mutation_p.P147S	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	147	Pro-rich.|Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			CGAAGCATAGGGGACTCTGAC	0.652													A	27308674	A	A	27308674	3	1	186	1	0	0	0	0	1	0	0	0	14142	1232	43	3	2622	3	SEZ6	17	27308674	Missense_Mutation	SNP	G	TCGA-27-1834-01A-01W-0643-08		27308674	53886536	61	13229											
PPM1D	8493	broad.mit.edu	37	chr17	58678099	58678099	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccgtgtgcgacgggcacggCgggcgggaggcggcacagtt	21	11	0	0			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr17:58678099C>T	uc002iyt.1	+	1	546	c.324C>T	c.(322-324)GGC>GGT	p.G108G	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	108	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			ACGGGCACGGCGGGCGGGAGG	0.692													T	58678099	T	T	58678099	2	4	186	1	0	0	0	0	0	0	0	1	12337	755	27	1		1	PPM1D	17	58678099	Silent	SNP	C	TCGA-27-1834-01A-01W-0643-08	31369425	58678099	22517111	62	13230											
SLC39A11	201266	broad.mit.edu	37	chr17	70644980	70644980	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgatgtcgtccatgaccacGtagaccatggcaccggcagc	11	13	0	3	rs146713017		TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr17:70644980G>A	uc002jjb.2	-	9	1027	c.912C>T	c.(910-912)TAC>TAT	p.Y304Y	SLC39A11_uc002jja.2_Silent_p.Y297Y	NM_001159770	NP_001153242	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11 isoform 1	304	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)	1						CCATGACCACGTAGACCATGG	0.642													A	70644980	A	A	70644980	2	1	186	1	0	0	0	0	0	0	0	1	14614	1140	40	1		1	SLC39A11	17	70644980	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08	11966881	70644980	10550230	63	13231											
TBC1D16	125058	broad.mit.edu	37	chr17	77915925	77915925	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtgcaggagcatctggtcCgtggccagctgctgctcgat	14	11	1	0	rs149251119	byFrequency	TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr17:77915925C>T	uc002jxj.2	-	11	2105	c.1989G>A	c.(1987-1989)ACG>ACA	p.T663T	TBC1D16_uc002jxh.2_Silent_p.T301T|TBC1D16_uc002jxi.2_Silent_p.T288T	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	663						intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			GCATCTGGTCCGTGGCCAGCT	0.622													T	77915925	T	T	77915925	2	4	186	1	0	0	0	0	0	0	0	1	15602	639	23	2		2	TBC1D16	17	77915925	Silent	SNP	C	TCGA-27-1834-01A-01W-0643-08	7270945	77915925	3279285	64	13232											
CYP2A13	1553	broad.mit.edu	37	chr19	41597775	41597775	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctggatcccaattccccaCgggacttcatcgactccttt	7	16	1	0	rs143140637		TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr19:41597775C>T	uc002opt.2	+	5	802	c.793C>T	c.(793-795)CGG>TGG	p.R265W		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	265					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	CAATTCCCCACGGGACTTCAT	0.582													T	41597775	T	T	41597775	3	4	186	1	0	0	0	0	1	0	0	0	4161	527	19	1	811	1	CYP2A13	19	41597775	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08		41597775	17531208	65	13233											
HAO1	54363	broad.mit.edu	37	chr20	7915230	7915230	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctctgtcctaaaacagaagTcgacagatctgtttcagcaa	7	11	3	2			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr20:7915230T>G	uc002wmw.1	-	2	214	c.190A>C	c.(190-192)ACT>CCT	p.T64P	HAO1_uc010gbu.2_Missense_Mutation_p.T64P	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	64	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						AAAACAGAAGTCGACAGATCT	0.458													G	7915230	G	G	7915230	3	3	186	1	0	0	0	0	1	0	0	0	6951	1667	58	5	950	5	HAO1	20	7915230	Missense_Mutation	SNP	T	TCGA-27-1834-01A-01W-0643-08		7915230	55110290	66	13234											
CSTF1	1477	broad.mit.edu	37	chr20	54978729	54978729	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accaaccccgggttcatgacGtgcagcgatgacttcagagc	11	13	2	3			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr20:54978729G>A	uc002xxl.1	+	6	1442	c.1242G>A	c.(1240-1242)ACG>ACA	p.T414T	CSTF1_uc002xxm.1_Silent_p.T414T|CSTF1_uc002xxn.1_Silent_p.T414T|CSTF1_uc002xxo.1_Silent_p.T357T	NM_001033521	NP_001028693	Q05048	CSTF1_HUMAN	cleavage stimulation factor subunit 1	414	WD 6.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(1)	1			Colorectal(105;0.202)			GGTTCATGACGTGCAGCGATG	0.587													A	54978729	A	A	54978729	2	1	186	1	0	0	0	0	0	0	0	1	3983	1132	40	1		1	CSTF1	20	54978729	Silent	SNP	G	TCGA-27-1834-01A-01W-0643-08	47063499	54978729	8046791	67	13235											
COL6A2	1292	broad.mit.edu	37	chr21	47545941	47545941	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cggacgggcgccacgaccctCgggacgatgacctcaacttg	13	15	1	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chr21:47545941C>T	uc002zia.1	+	26	2294	c.2212C>T	c.(2212-2214)CGG>TGG	p.R738W	COL6A2_uc002zhy.1_Missense_Mutation_p.R738W|COL6A2_uc002zhz.1_Missense_Mutation_p.R738W|COL6A2_uc002zib.1_Missense_Mutation_p.R144W|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	738	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCACGACCCTCGGGACGATGA	0.622													T	47545941	T	T	47545941	3	4	186	1	0	0	0	0	1	0	0	0	3700	875	31	2	2310	2	COL6A2	21	47545941	Missense_Mutation	SNP	C	TCGA-27-1834-01A-01W-0643-08		47545941	583954	68	13236											
CSF2RA	1438	broad.mit.edu	37	chrX	1407665	1407665	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcccaggaagggagggtacCgctgctcagaatttctcctg	12	11	2	1			TCGA-27-1834-01A-01W-0643-08	TCGA-27-1834-10A-01W-0644-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6c0824e-3d2a-498a-af77-44ea96ba5ce4	732875cd-e439-43d9-8720-e45f5cbbefae	g.chrX:1407665C>T	uc010nct.2	+	7	679	c.357C>T	c.(355-357)ACC>ACT	p.T119T	CSF2RA_uc011mhb.1_Silent_p.T119T|CSF2RA_uc004cpq.2_Silent_p.T119T|CSF2RA_uc004cpn.2_Silent_p.T119T|CSF2RA_uc004cpo.2_Silent_p.T119T|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_5'UTR|CSF2RA_uc004cpp.2_Silent_p.T119T|CSF2RA_uc010ncv.2_Silent_p.T119T|CSF2RA_uc004cpr.2_Silent_p.T119T	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	119	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GGGAGGGTACCGCTGCTCAGA	0.517													T	1407665	T	T	1407665	2	4	186	1	0	0	0	0	0	0	0	1	3934	639	23	2		2	CSF2RA	23	1407665	Silent	SNP	C	TCGA-27-1834-01A-01W-0643-08		1407665	153862895	69	13237											
PLEKHO1	51177	broad.mit.edu	37	chr1	150131552	150131552	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagcagctgctgctggagaCggaacggctgctgggagagg	19	8	0	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr1:150131552C>T	uc001ett.2	+	6	1342	c.1064C>T	c.(1063-1065)ACG>ATG	p.T355M	PLEKHO1_uc001etr.2_Missense_Mutation_p.T183M|PLEKHO1_uc001ets.2_Missense_Mutation_p.T172M|PLEKHO1_uc001etu.2_Missense_Mutation_p.T183M	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	355	Negative regulator of AP-1 activity.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTGCTGGAGACGGAACGGCTG	0.607													T	150131552	T	T	150131552	3	4	187	1	0	0	0	0	1	0	0	0	12084	536	19	1	1086	1	PLEKHO1	1	150131552	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08		150131552	99119069	1	13238											
NUP210L	91181	broad.mit.edu	37	chr1	154110601	154110601	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctgtcactctcccttgaacCatttttgcaacttggtattt	5	12	2	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr1:154110601C>A	uc001fdw.2	-	6	903	c.831G>T	c.(829-831)ATG>ATT	p.M277I	NUP210L_uc009woq.2_5'Flank|NUP210L_uc010peh.1_Missense_Mutation_p.M277I	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	277						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TCCCTTGAACCATTTTTGCAA	0.343													A	154110601	A	A	154110601	3	1	187	1	0	0	0	0	1	0	0	0	10761	594	21	5	4975	5	NUP210L	1	154110601	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	3979049	154110601	95140020	2	13239											
SPTA1	6708	broad.mit.edu	37	chr1	158626393	158626393	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttccgcagagctttcatactGtctccaaatgaattgagatc	7	10	2	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr1:158626393G>C	uc001fst.1	-	20	3058	c.2859C>G	c.(2857-2859)GAC>GAG	p.D953E		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	953	Spectrin 10.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTTTCATACTGTCTCCAAATG	0.413													C	158626393	C	C	158626393	3	2	187	1	0	0	0	0	1	0	0	0	15115	1368	48	5	4532	5	SPTA1	1	158626393	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	4515792	158626393	90624228	3	13240											
SPTA1	6708	broad.mit.edu	37	chr1	158632602	158632602	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggtctaagagcttcttctttCgggtggccagtggctctttc	12	10	4	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr1:158632602C>T	uc001fst.1	-	17	2553	c.2354G>A	c.(2353-2355)CGA>CAA	p.R785Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	785	Spectrin 8.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTTCTTCTTTCGGGTGGCCAG	0.478													T	158632602	T	T	158632602	3	4	187	1	0	0	0	0	1	0	0	0	15115	884	31	2	5049	2	SPTA1	1	158632602	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	6209	158632602	90618019	4	13241											
LAMB3	3914	broad.mit.edu	37	chr1	209804029	209804029	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgtagaagggtgcacagcGctcacaatttgggccggcag	15	9	1	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr1:209804029G>A	uc001hhg.2	-	8	1264	c.874C>T	c.(874-876)CGC>TGC	p.R292C	LAMB3_uc009xco.2_Missense_Mutation_p.R292C|LAMB3_uc001hhh.2_Missense_Mutation_p.R292C|LAMB3_uc010psl.1_RNA|LAMB3_uc009xcp.1_Missense_Mutation_p.R228C	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	292	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGTGCACAGCGCTCACAATTT	0.597													A	209804029	A	A	209804029	3	1	187	1	0	0	0	0	1	0	0	0	8612	1087	38	1	2704	1	LAMB3	1	209804029	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	51171427	209804029	39446592	5	13242											
SIPA1L2	57568	broad.mit.edu	37	chr1	232615447	232615447	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcgtagtctttgtatgtggTatagagagagtgcgtgcccg	14	6	1	2			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr1:232615447T>C	uc001hvg.2	-	5	2169	c.2011A>G	c.(2011-2013)ACC>GCC	p.T671A		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	671	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTGTATGTGGTATAGAGAGAG	0.448													C	232615447	C	C	232615447	3	2	187	1	0	0	0	0	1	0	0	0	14330	1638	57	4	3225	4	SIPA1L2	1	232615447	Missense_Mutation	SNP	T	TCGA-27-1835-01A-01D-1494-08	22811418	232615447	16635174	6	13243											
KIAA1804	84451	broad.mit.edu	37	chr1	233515030	233515030	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaggaagagaagaagaaaCgagagggaatcttccagcgg	14	7	1	4			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr1:233515030C>T	uc001hvt.3	+	9	2539	c.2278C>T	c.(2278-2280)CGA>TGA	p.R760*	KIAA1804_uc001hvu.3_Nonsense_Mutation_p.R206*	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	760					activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				GAAGAAGAAACGAGAGGGAAT	0.602													T	233515030	T	T	233515030	4	4	187	1	0	0	0	0	0	1	0	0	8259	528	19	1	2312	1	KIAA1804	1	233515030	Nonsense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	899583	233515030	15735591	7	13244											
OR2M4	26245	broad.mit.edu	37	chr1	248402638	248402638	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cttcagtacaccatcctcatGaatccgaaactctgtgtctt	5	13	4	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr1:248402638G>T	uc010pzh.1	+	1	408	c.408G>T	c.(406-408)ATG>ATT	p.M136I		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCATCCTCATGAATCCGAAAC	0.473													T	248402638	T	T	248402638	3	4	187	1	0	0	0	0	1	0	0	0	11012	1290	45	5	410	5	OR2M4	1	248402638	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	14887608	248402638	847983	8	13245											
IFT172	26160	broad.mit.edu	37	chr2	27670769	27670769	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctcaccatgtcagtgaagatCcttttgtagatattgaagtt	8	7	2	4			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr2:27670769C>A	uc002rku.2	-	41	4500	c.4449G>T	c.(4447-4449)AGG>AGT	p.R1483S	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1483					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					CAGTGAAGATCCTTTTGTAGA	0.502													A	27670769	A	A	27670769	3	1	187	1	0	0	0	0	1	0	0	0	7557	854	30	5	832	5	IFT172	2	27670769	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08		27670769	215528604	9	13246											
CAPN13	92291	broad.mit.edu	37	chr2	30959413	30959413	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cagtcgcgcaaactcctcttGgtctagccgcccattcactt	7	16	3	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr2:30959413G>T	uc002rnn.2	-	17	1854	c.1678C>A	c.(1678-1680)CAA>AAA	p.Q560K	CAPN13_uc002rnm.2_RNA	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	560	EF-hand 1.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AACTCCTCTTGGTCTAGCCGC	0.493													T	30959413	T	T	30959413	3	4	187	1	0	0	0	0	1	0	0	0	2626	1357	47	5	351	5	CAPN13	2	30959413	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	3288644	30959413	212239960	10	13247											
FAM82A1	151393	broad.mit.edu	37	chr2	38202445	38202445	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacacaagaaaagaaacatTatgctaatattggtaagcat	6	6	0	2			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr2:38202445T>C	uc002rql.2	+	4	841	c.718T>C	c.(718-720)TAT>CAT	p.Y240H	FAM82A1_uc002rqn.1_Missense_Mutation_p.Y418H|FAM82A1_uc002rqk.1_Missense_Mutation_p.Y95H|FAM82A1_uc002rqm.2_Missense_Mutation_p.Y95H	NM_144713	NP_653314	Q96LZ7	RMD2_HUMAN	family with sequence similarity 82, member A1	240						cytoplasm|integral to membrane|microtubule|spindle pole	binding			ovary(1)	1						AAAGAAACATTATGCTAATAT	0.254													C	38202445	C	C	38202445	3	2	187	1	0	0	0	0	1	0	0	0	5630	1754	61	4	1722	4	FAM82A1	2	38202445	Missense_Mutation	SNP	T	TCGA-27-1835-01A-01D-1494-08	7243032	38202445	204996928	11	13248											
SULT1C4	27233	broad.mit.edu	37	chr2	108999906	108999906	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggcatgaacatgtgaaaggAtggtgggaagccaaagacaa	14	5	0	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr2:108999906A>T	uc002tea.1	+	5	928	c.555A>T	c.(553-555)GGA>GGT	p.G185G	SULT1C4_uc010ywr.1_RNA|SULT1C4_uc002teb.1_Silent_p.G110G	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member	185					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0						ATGTGAAAGGATGGTGGGAAG	0.478													T	108999906	T	T	108999906	2	4	187	1	0	0	0	0	0	0	0	1	15376	320	12	5		5	SULT1C4	2	108999906	Silent	SNP	A	TCGA-27-1835-01A-01D-1494-08	70797461	108999906	134199467	12	13249											
RPRM	56475	broad.mit.edu	37	chr2	154334770	154334770	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagtagggccccacgaccaCcgcctccacctccttagacg	8	19	1	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr2:154334770C>T	uc002tyq.1	-	1	553	c.310G>A	c.(310-312)GTG>ATG	p.V104M		NM_019845	NP_062819	Q9NS64	RPRM_HUMAN	reprimo, TP53 dependant G2 arrest mediator	104					cell cycle arrest	cytoplasm|integral to membrane	protein binding				0						CCCACGACCACCGCCTCCACC	0.637													T	154334770	T	T	154334770	3	4	187	1	0	0	0	0	1	0	0	0	13618	507	18	3	23	3	RPRM	2	154334770	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	45334864	154334770	88864603	13	13250											
STAT4	6775	broad.mit.edu	37	chr2	192011451	192011451	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaagttttgaagaagaatcGttgccatggtttcattgtta	9	5	1	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr2:192011451G>A	uc002usm.1	-	3	415	c.161C>T	c.(160-162)ACG>ATG	p.T54M	STAT4_uc010zgm.1_RNA|STAT4_uc010zgn.1_RNA|STAT4_uc010zgo.1_RNA|STAT4_uc002usn.1_Missense_Mutation_p.T54M|STAT4_uc002uso.2_Missense_Mutation_p.T54M|STAT4_uc002usp.3_Missense_Mutation_p.T54M|STAT4_uc010zgl.1_Missense_Mutation_p.T54M	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	54					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			AAGAAGAATCGTTGCCATGGT	0.323													A	192011451	A	A	192011451	3	1	187	1	0	0	0	0	1	0	0	0	15266	1145	40	1	2173	1	STAT4	2	192011451	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	37676681	192011451	51187922	14	13251											
CD28	940	broad.mit.edu	37	chr2	204599561	204599561	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actacatgaacatgactcccCgccgccccgggcccacccgc	8	21	0	2			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr2:204599561C>T	uc002vah.3	+	4	811	c.589C>T	c.(589-591)CGC>TGC	p.R197C	CD28_uc010zio.1_RNA|CD28_uc010ftx.2_Missense_Mutation_p.R78C|CD28_uc002vaj.3_RNA	NM_006139	NP_006130	P10747	CD28_HUMAN	CD28 antigen precursor	197	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity				0						CATGACTCCCCGCCGCCCCGG	0.597													T	204599561	T	T	204599561	3	4	187	1	0	0	0	0	1	0	0	0	2993	652	23	2	603	2	CD28	2	204599561	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	12588110	204599561	38599812	15	13252											
SNRK	54861	broad.mit.edu	37	chr3	43381834	43381834	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaagggcttctttagaagagAttgaaaatcatccttggctt	10	6	2	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr3:43381834A>C	uc003cms.3	+	5	1119	c.787A>C	c.(787-789)ATT>CTT	p.I263L	SNRK_uc003cmt.3_Missense_Mutation_p.I263L|SNRK_uc010hik.2_Missense_Mutation_p.I263L|SNRK_uc011azr.1_Missense_Mutation_p.I57L	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase	263	Protein kinase.				myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		TTTAGAAGAGATTGAAAATCA	0.443													C	43381834	C	C	43381834	3	2	187	1	0	0	0	0	1	0	0	0	14851	333	12	5	797	5	SNRK	3	43381834	Missense_Mutation	SNP	A	TCGA-27-1835-01A-01D-1494-08		43381834	154640596	16	13253											
LETM1	3954	broad.mit.edu	37	chr4	1818642	1818642	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcttgatctcctgcaagtcCtaataaaattattttggttg	6	7	2	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr4:1818642C>T	uc003gdv.2	-	12	2041	c.1744_splice	c.e12-1	p.D582_splice		NM_012318	NP_036450	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane						cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			central_nervous_system(1)	1			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			CCTGCAAGTCCTAATAAAATT	0.264													T	1818642	T	T	1818642	5	4	187	1	0	0	0	0	0	0	1	0	8734	695	24	3	488	3	LETM1	4	1818642	Splice_Site	SNP	C	TCGA-27-1835-01A-01D-1494-08		1818642	189335634	17	13254											
WHSC1	7468	broad.mit.edu	37	chr4	1978378	1978378	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accaaggcctaccacctgtcCtgcctgggccttggcaagcg	11	16	0	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr4:1978378C>A	uc003gdz.3	+	21	3974	c.3798C>A	c.(3796-3798)TCC>TCA	p.S1266S	WHSC1_uc003geb.3_Silent_p.S1266S|WHSC1_uc003gec.3_Silent_p.S1266S|WHSC1_uc003ged.3_Silent_p.S1266S|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Silent_p.S485S|WHSC1_uc011bvh.1_Silent_p.S327S|WHSC1_uc010icf.2_Silent_p.S614S	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1266	PHD-type 4; atypical.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		ACCACCTGTCCTGCCTGGGCC	0.657			T	IGH@	MM								A	1978378	A	A	1978378	2	1	187	1	0	0	0	0	0	0	0	1	17359	668	24	5		5	WHSC1	4	1978378	Silent	SNP	C	TCGA-27-1835-01A-01D-1494-08	159736	1978378	189175898	18	13255											
FAM193A	8603	broad.mit.edu	37	chr4	2692666	2692667	+	Frame_Shift_Del	DEL	CA	-	-													cagtccagcaacagccagttCagagtgtcatccaagagacc							TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr4:2692666_2692667delCA	uc010icl.2	+	13	2250_2251	c.1899_1900delCA	c.(1897-1902)TTCAGAfs	p.F633fs	FAM193A_uc010ick.2_Frame_Shift_Del_p.F833fs|FAM193A_uc003gfd.2_Frame_Shift_Del_p.F633fs|FAM193A_uc011bvm.1_Frame_Shift_Del_p.F655fs|FAM193A_uc011bvn.1_Frame_Shift_Del_p.F633fs|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Frame_Shift_Del_p.F487fs	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	633_634										ovary(3)	3						ACAGCCAGTTCAGAGTGTCATC	0.53													-	2692667	-	-	2692666	7	5	187	1	0	1	0	1	0	0	0	0	5524	825	29	0	1941	0	FAM193A	4	2692666	Frame_Shift_Del	DEL	CA	TCGA-27-1835-01A-01D-1494-08	714288	2692666	188461610	19	13256											
USP46	64854	broad.mit.edu	37	chr4	53468067	53468067	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	accaagtcatacatgcggtcCaggttcactgcatcactgga	9	12	3	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr4:53468067C>G	uc003gzn.2	-	7	1061	c.876G>C	c.(874-876)CTG>CTC	p.L292L	USP46_uc003gzm.3_Silent_p.L285L|USP46_uc011bzr.1_Silent_p.L269L|USP46_uc011bzs.1_Silent_p.L176L	NM_022832	NP_073743	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46 isoform 1	292					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0295)			ACATGCGGTCCAGGTTCACTG	0.537													G	53468067	G	G	53468067	2	3	187	1	0	0	0	0	0	0	0	1	17074	581	21	5		5	USP46	4	53468067	Silent	SNP	C	TCGA-27-1835-01A-01D-1494-08	50775401	53468067	137686209	20	13257											
C4orf40	401137	broad.mit.edu	37	chr4	71024299	71024299	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccctcctaggggtttcccGtttgtccctccttcaaggtt	8	15	1	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr4:71024299G>A	uc003hfa.3	+	4	403	c.330G>A	c.(328-330)CCG>CCA	p.P110P	C4orf40_uc003hfb.3_Silent_p.P110P	NM_214711	NP_999876	Q6MZM9	CD040_HUMAN	hypothetical protein LOC401137 precursor	110						extracellular region					0						GGGGTTTCCCGTTTGTCCCTC	0.532													A	71024299	A	A	71024299	2	1	187	1	0	0	0	0	0	0	0	1	2269	1132	40	1		1	C4orf40	4	71024299	Silent	SNP	G	TCGA-27-1835-01A-01D-1494-08	17556232	71024299	120129977	21	13258											
PRDM5	11107	broad.mit.edu	37	chr4	121720881	121720884	+	Frame_Shift_Del	DEL	CAAT	-	-													atttcttcatacattcttgaCaatcaaatatctcatgaatc					rs34666716	byFrequency	TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr4:121720881_121720884delCAAT	uc003idn.2	-	9	1212_1215	c.962_965delATTG	c.(961-966)GATTGTfs	p.D321fs	PRDM5_uc003ido.2_Frame_Shift_Del_p.D290fs|PRDM5_uc010ine.2_Frame_Shift_Del_p.D290fs	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	321_322	C2H2-type 6.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						ACATTCTTGACAATCAAATATCTC	0.309													-	121720884	-	-	121720881	7	5	187	1	0	1	0	1	0	0	0	0	12460	478	17	0	959	0	PRDM5	4	121720881	Frame_Shift_Del	DEL	CAAT	TCGA-27-1835-01A-01D-1494-08	50696582	121720881	69433395	22	13259											
GPR98	84059	broad.mit.edu	37	chr5	89981612	89981612	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagttccaaattctccacGtcttgggcctaaggtagaaa	8	10	3	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr5:89981612G>A	uc003kju.2	+	29	6386	c.6290G>A	c.(6289-6291)CGT>CAT	p.R2097H	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2097	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AATTCTCCACGTCTTGGGCCT	0.423													A	89981612	A	A	89981612	3	1	187	1	0	0	0	0	1	0	0	0	6721	1145	40	1	6404	1	GPR98	5	89981612	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08		89981612	90933648	23	13260											
ADAMTS19	171019	broad.mit.edu	37	chr5	128957961	128957961	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgatggttccctccaagCtgccagggatgacatacact	10	12	0	2			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr5:128957961C>G	uc003kvb.1	+	10	1672	c.1672C>G	c.(1672-1674)CTG>GTG	p.L558V	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	558	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		TCCCTCCAAGCTGCCAGGGAT	0.468													G	128957961	G	G	128957961	3	3	187	1	0	0	0	0	1	0	0	0	264	796	28	5	1710	5	ADAMTS19	5	128957961	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	38976349	128957961	51957299	24	13261											
GABRA6	2559	broad.mit.edu	37	chr5	161116169	161116169	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaatggaaccattttatacaCcatgaggtgaggtttctcca	9	8	1	2			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr5:161116169C>A	uc003lyu.2	+	4	778	c.440C>A	c.(439-441)ACC>AAC	p.T147N	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	147	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATTTTATACACCATGAGGTGA	0.373										TCGA Ovarian(5;0.080)			A	161116169	A	A	161116169	3	1	187	1	0	0	0	0	1	0	0	0	6165	507	18	5	454	5	GABRA6	5	161116169	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	32158208	161116169	19799091	25	13262											
DDX41	51428	broad.mit.edu	37	chr5	176943782	176943782	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cacgtagtcctcgtcgtcctCatcttccgcctcggagcggc	10	17	2	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr5:176943782C>G	uc003mho.2	-	2	103	c.82G>C	c.(82-84)GAG>CAG	p.E28Q	DDX41_uc003mhm.2_5'Flank|DDX41_uc003mhn.2_5'UTR|DDX41_uc003mhp.2_5'UTR|DDX41_uc003mhq.1_5'UTR	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	28				PAGGSRSEAEDEDDEDYVPYVPLRQRR -> LPEEAAPRRK MRTTRTTCPMCRYAAP (in Ref. 1; AAF04150).	apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TCGTCGTCCTCATCTTCCGCC	0.706													G	176943782	G	G	176943782	3	3	187	1	0	0	0	0	1	0	0	0	4361	835	29	5	1850	5	DDX41	5	176943782	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	15827613	176943782	3971478	26	13263											
GPR116	221395	broad.mit.edu	37	chr6	46826114	46826114	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgatcagtgctgggatggCgaaagccagcagggccttgg	16	8	1	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr6:46826114C>T	uc003oyo.3	-	17	3815	c.3526G>A	c.(3526-3528)GCC>ACC	p.A1176T	GPR116_uc011dwj.1_Missense_Mutation_p.A731T|GPR116_uc011dwk.1_Missense_Mutation_p.A605T|GPR116_uc003oyp.3_Missense_Mutation_p.A1034T|GPR116_uc003oyq.3_Missense_Mutation_p.A1176T|GPR116_uc010jzi.1_Missense_Mutation_p.A848T	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1176	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			GCTGGGATGGCGAAAGCCAGC	0.547													T	46826114	T	T	46826114	3	4	187	1	0	0	0	0	1	0	0	0	6633	768	27	1	534	1	GPR116	6	46826114	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08		46826114	124288953	27	13264											
NT5E	4907	broad.mit.edu	37	chr6	86197137	86197137	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attagggaaaacaattgtctAtctggatggctcctctcaat	8	8	3	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr6:86197137A>G	uc003pko.3	+	5	1590	c.1034A>G	c.(1033-1035)TAT>TGT	p.Y345C	NT5E_uc010kbr.2_Missense_Mutation_p.Y345C	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	345					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	ACAATTGTCTATCTGGATGGC	0.393													G	86197137	G	G	86197137	3	3	187	1	0	0	0	0	1	0	0	0	10693	449	16	4	1052	4	NT5E	6	86197137	Missense_Mutation	SNP	A	TCGA-27-1835-01A-01D-1494-08	39371023	86197137	84917930	28	13265											
MDN1	23195	broad.mit.edu	37	chr6	90362720	90362720	+	Frame_Shift_Del	DEL	C	-	-													agttttactacctggaagatCgtgtccatgaggaattgatg							TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr6:90362720delC	uc003pnn.1	-	94	15932	c.15816delG	c.(15814-15816)ACGfs	p.T5272fs		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5272					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCTGGAAGATCGTGTCCATGA	0.333													-	90362720	-	-	90362720	7	5	187	1	0	1	0	1	0	0	0	0	9415	871	31	0	1010	0	MDN1	6	90362720	Frame_Shift_Del	DEL	C	TCGA-27-1835-01A-01D-1494-08	4165583	90362720	80752347	29	13266											
MAP3K7	6885	broad.mit.edu	37	chr6	91281453	91281453	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcctctcagattcactttctAtttgtttaatagcaacatct	3	10	4	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr6:91281453A>G	uc003pnz.1	-	2	356	c.194T>C	c.(193-195)ATA>ACA	p.I65T	MAP3K7_uc003poa.1_Missense_Mutation_p.I65T|MAP3K7_uc003pob.1_Missense_Mutation_p.I65T|MAP3K7_uc003poc.1_Missense_Mutation_p.I65T	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	65	Protein kinase.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		TTCACTTTCTATTTGTTTAAT	0.318													G	91281453	G	G	91281453	3	3	187	1	0	0	0	0	1	0	0	0	9255	449	16	4	1690	4	MAP3K7	6	91281453	Missense_Mutation	SNP	A	TCGA-27-1835-01A-01D-1494-08	918733	91281453	79833614	30	13267											
SLC16A10	117247	broad.mit.edu	37	chr6	111498841	111498841	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaataccacttgcacttttTggatactttgtgccttatgt	8	8	0	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr6:111498841T>C	uc003pus.2	+	3	1090	c.915T>C	c.(913-915)TTT>TTC	p.F305F	SLC16A10_uc003pur.3_Silent_p.F305F|SLC16A10_uc003put.2_5'UTR	NM_018593	NP_061063	Q8TF71	MOT10_HUMAN	solute carrier family 16, member 10	305	Helical; (Potential).				aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity				0		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		TTGCACTTTTTGGATACTTTG	0.363													C	111498841	C	C	111498841	2	2	187	1	0	0	0	0	0	0	0	1	14403	1809	63	4		4	SLC16A10	6	111498841	Silent	SNP	T	TCGA-27-1835-01A-01D-1494-08	20217388	111498841	59616226	31	13268											
RSPH4A	345895	broad.mit.edu	37	chr6	116938051	116938051	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ctgctcctgtctctccgcggGagccctcttcctctccttct	7	19	4	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr6:116938051G>T	uc003pxe.2	+	1	410	c.265G>T	c.(265-267)GAG>TAG	p.E89*	RSPH4A_uc010kee.2_Nonsense_Mutation_p.E89*	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	89					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						CTCTCCGCGGGAGCCCTCTTC	0.647									Kartagener_syndrome				T	116938051	T	T	116938051	4	4	187	1	0	0	0	0	0	1	0	0	13706	1175	41	5	267	5	RSPH4A	6	116938051	Nonsense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	5439210	116938051	54177016	32	13269											
RFX6	222546	broad.mit.edu	37	chr6	117244279	117244279	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tttacttttagaccagcaaaCaaaatggaaggtcattaaag	7	6	1	1	rs144863251		TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr6:117244279C>A	uc003pxm.2	+	14	1510	c.1447C>A	c.(1447-1449)CAA>AAA	p.Q483K		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	483					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding	p.Q483K(1)		ovary(1)|pancreas(1)|skin(1)	3						GACCAGCAAACAAAATGGAAG	0.363													A	117244279	A	A	117244279	3	1	187	1	0	0	0	0	1	0	0	0	13267	479	17	5	1501	5	RFX6	6	117244279	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	306228	117244279	53870788	33	13270											
CNKSR3	154043	broad.mit.edu	37	chr6	154743668	154743668	+	Frame_Shift_Del	DEL	T	-	-													gaggtggcttccaccgtaggTttttcaggggagcaggagta							TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr6:154743668delT	uc003qpy.2	-	9	1422	c.917delA	c.(916-918)AACfs	p.N306fs		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	306					negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CCACCGTAGGTTTTTCAGGGG	0.448													-	154743668	-	-	154743668	7	5	187	1	0	1	0	1	0	0	0	0	3608	1725	60	0	770	0	CNKSR3	6	154743668	Frame_Shift_Del	DEL	T	TCGA-27-1835-01A-01D-1494-08	37499389	154743668	16371399	34	13271											
DLL1	28514	broad.mit.edu	37	chr6	170599203	170599203	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaggccgagagcaccgccaGggccagcgcgcaccgactgc	14	17	0	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr6:170599203G>A	uc003qxm.2	-	1	495	c.25C>T	c.(25-27)CTG>TTG	p.L9L	DLL1_uc011ehc.1_Silent_p.L9L|DLL1_uc003qxn.3_Silent_p.L9L	NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	9					cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		AGCACCGCCAGGGCCAGCGCG	0.647													A	170599203	A	A	170599203	2	1	187	1	0	0	0	0	0	0	0	1	4566	991	35	3		3	DLL1	6	170599203	Silent	SNP	G	TCGA-27-1835-01A-01D-1494-08	15855535	170599203	515864	35	13272											
HOXA6	3203	broad.mit.edu	37	chr7	27186942	27186942	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttacccgcgcaggagttcaTccgctgcatccaagggtaaa	10	13	1	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr7:27186942T>G	uc003syo.1	-	1	427	c.427A>C	c.(427-429)ATG>CTG	p.M143L	uc003syp.1_Missense_Mutation_p.S9A	NM_024014	NP_076919	P31267	HXA6_HUMAN	homeobox A6	143						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						CAGGAGTTCATCCGCTGCATC	0.493													G	27186942	G	G	27186942	3	3	187	1	0	0	0	0	1	0	0	0	7296	1435	50	5	282	5	HOXA6	7	27186942	Missense_Mutation	SNP	T	TCGA-27-1835-01A-01D-1494-08		27186942	131951721	36	13273											
TXNDC3	51314	broad.mit.edu	37	chr7	37903981	37903981	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agtattgctattatcaaaccGgatgctgtgattagtaaaaa	8	5	1	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr7:37903981G>C	uc003tfn.2	+	9	858	c.486G>C	c.(484-486)CCG>CCC	p.P162P		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	162	NDK 1.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TTATCAAACCGGATGCTGTGA	0.284									Kartagener_syndrome				C	37903981	C	C	37903981	2	2	187	1	0	0	0	0	0	0	0	1	16795	1103	39	5		5	TXNDC3	7	37903981	Silent	SNP	G	TCGA-27-1835-01A-01D-1494-08	10717039	37903981	121234682	37	13274											
ABCB1	5243	broad.mit.edu	37	chr7	87179256	87179256	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gacattttcacggccatagcGaatgttttcagctatcgtgg	10	9	2	0	rs142600685	byFrequency	TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr7:87179256G>A	uc003uiz.1	-	14	1883	c.1465C>T	c.(1465-1467)CGC>TGC	p.R489C	ABCB1_uc011khc.1_Missense_Mutation_p.R425C	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	489	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CGGCCATAGCGAATGTTTTCA	0.428													A	87179256	A	A	87179256	3	1	187	1	0	0	0	0	1	0	0	0	40	1058	37	2	2441	2	ABCB1	7	87179256	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	49275275	87179256	71959407	38	13275											
MCM7	4176	broad.mit.edu	37	chr7	99693696	99693696	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtcagccagcaccagggcCccaccctctaaggtcagttc	10	16	3	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr7:99693696C>T	uc003usw.1	-	11	1806	c.1296G>A	c.(1294-1296)GGG>GGA	p.G432G	MCM7_uc003usv.1_Silent_p.G256G|MCM7_uc003usx.1_Silent_p.G256G|uc003usy.1_5'Flank|MIR25_hsa-mir-25|MI0000082_5'Flank|uc003usz.1_5'Flank|MIR93_hsa-mir-93|MI0000095_5'Flank|uc003uta.1_5'Flank|MIR106B_hsa-mir-106b|MI0000734_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	432	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	GCACCAGGGCCCCACCCTCTA	0.612													T	99693696	T	T	99693696	2	4	187	1	0	0	0	0	0	0	0	1	9392	610	22	3		3	MCM7	7	99693696	Silent	SNP	C	TCGA-27-1835-01A-01D-1494-08	12514440	99693696	59444967	39	13276											
MUC17	140453	broad.mit.edu	37	chr7	100681846	100681846	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatctcctacaactgctgaCgatactagcatgccaacctc	5	15	2	1	rs138267850		TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr7:100681846C>T	uc003uxp.1	+	3	7202	c.7149C>T	c.(7147-7149)GAC>GAT	p.D2383D	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2383	Extracellular (Potential).|59 X approximate tandem repeats.|38.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAACTGCTGACGATACTAGCA	0.498													T	100681846	T	T	100681846	2	4	187	1	0	0	0	0	0	0	0	1	9974	535	19	1		1	MUC17	7	100681846	Silent	SNP	C	TCGA-27-1835-01A-01D-1494-08	988150	100681846	58456817	40	13277											
PIK3CG	5294	broad.mit.edu	37	chr7	106508257	106508257	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgctggagaccagcgtggCggcggacttctaccaccggc	15	14	1	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr7:106508257C>T	uc003vdv.3	+	2	336	c.251C>T	c.(250-252)GCG>GTG	p.A84V	PIK3CG_uc003vdu.2_Missense_Mutation_p.A84V|PIK3CG_uc003vdw.2_Missense_Mutation_p.A84V	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	84					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						ACCAGCGTGGCGGCGGACTTC	0.637													T	106508257	T	T	106508257	3	4	187	1	0	0	0	0	1	0	0	0	11916	768	27	1	253	1	PIK3CG	7	106508257	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	5826411	106508257	52630406	41	13278											
EBF2	64641	broad.mit.edu	37	chr8	25766052	25766052	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acaattctgattgcacttgaGgaaaaattttaaaaagaatc	6	5	1	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr8:25766052G>T	uc003xes.1	-	7	588	c.571C>A	c.(571-573)CTC>ATC	p.L191I	PPP2R2A_uc003xek.2_Intron	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	191					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TTGCACTTGAGGAAAAATTTT	0.363													T	25766052	T	T	25766052	3	4	187	1	0	0	0	0	1	0	0	0	4881	1000	35	5	1196	5	EBF2	8	25766052	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08		25766052	120597970	42	13279											
TMC1	117531	broad.mit.edu	37	chr9	75441788	75441789	+	Frame_Shift_Ins	INS	-	A	A													tttttaattcccccagtggcINSaaaaatagaatgtttgaagt							TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr9:75441788_75441789insA	uc004aiz.1	+	21	2547_2548	c.2007_2008insA	c.(2005-2010)GGCAAAfs	p.G669fs	TMC1_uc010moz.1_Frame_Shift_Ins_p.G627fs|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Frame_Shift_Ins_p.G523fs|TMC1_uc010mpa.1_Frame_Shift_Ins_p.G523fs	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	669_670	Extracellular (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						CCCCCAGTGGCAAAAATAGAAT	0.411													A	75441789	A	A	75441788	7	5	187	1	0	1	1	0	0	0	0	0	15981	697	25	0	2073	0	TMC1	9	75441788	Frame_Shift_Ins	INS	-	TCGA-27-1835-01A-01D-1494-08		75441788	65771643	43	13280											
ACTL7B	10880	broad.mit.edu	37	chr9	111618206	111618206	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatggggctgttccttgtcGccatctgcctcccttgctcc	10	16	1	0	rs139165156		TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr9:111618206G>A	uc004bdi.2	-	1	70	c.5C>T	c.(4-6)GCG>GTG	p.A2V		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	2						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						GTTCCTTGTCGCCATCTGCCT	0.667													A	111618206	A	A	111618206	3	1	187	1	0	0	0	0	1	0	0	0	201	1087	38	1	1246	1	ACTL7B	9	111618206	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	36176418	111618206	29595225	44	13281											
COL5A1	1289	broad.mit.edu	37	chr9	137620520	137620520	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcaattcgctttcagtacaCggaaggagacggcgagggtg	15	9	1	1	rs148548209		TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr9:137620520C>T	uc004cfe.2	+	6	1173	c.791C>T	c.(790-792)ACG>ATG	p.T264M		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	264	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TTTCAGTACACGGAAGGAGAC	0.612													T	137620520	T	T	137620520	3	4	187	1	0	0	0	0	1	0	0	0	3696	536	19	1	813	1	COL5A1	9	137620520	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	26002314	137620520	3592911	45	13282											
CALML5	51806	broad.mit.edu	37	chr10	5540984	5540984	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctgggcgagcatcctcgCgaactcctcgtagttcaccc	9	17	1	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr10:5540984C>T	uc001iic.2	-	1	550	c.418G>A	c.(418-420)GCG>ACG	p.A140T		NM_017422	NP_059118	Q9NZT1	CALL5_HUMAN	calmodulin-like 5	140	EF-hand 4.				epidermis development|signal transduction		calcium ion binding|protein binding				0						AGCATCCTCGCGAACTCCTCG	0.701													T	5540984	T	T	5540984	3	4	187	1	0	0	0	0	1	0	0	0	2589	768	27	1	26	1	CALML5	10	5540984	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08		5540984	129993763	46	13283											
SLK	9748	broad.mit.edu	37	chr10	105752828	105752828	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actacttacatgataataagAtcatccacagagatctgaag	6	8	2	4			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr10:105752828A>G	uc001kxo.1	+	4	485	c.451A>G	c.(451-453)ATC>GTC	p.I151V	SLK_uc001kxp.1_Missense_Mutation_p.I151V	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	151	Protein kinase.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGATAATAAGATCATCCACAG	0.333													G	105752828	G	G	105752828	3	3	187	1	0	0	0	0	1	0	0	0	14748	333	12	4	465	4	SLK	10	105752828	Missense_Mutation	SNP	A	TCGA-27-1835-01A-01D-1494-08	100211844	105752828	29781919	47	13284											
IFITM1	8519	broad.mit.edu	37	chr11	314342	314342	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctgggcttcatagcattcGcctactccgtgaaggtgcgt	12	11	2	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr11:314342G>A	uc001loy.3	+	1	352	c.172G>A	c.(172-174)GCC>ACC	p.A58T		NM_003641	NP_003632	P13164	IFM1_HUMAN	interferon induced transmembrane protein 1	58	Cytoplasmic (Potential).				negative regulation of cell proliferation|regulation of immune response|response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane	protein binding|receptor signaling protein activity				0		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CATAGCATTCGCCTACTCCGT	0.612													A	314342	A	A	314342	3	1	187	1	0	0	0	0	1	0	0	0	7526	1087	38	1	174	1	IFITM1	11	314342	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08		314342	134692174	48	13285											
SYT9	143425	broad.mit.edu	37	chr11	7334771	7334771	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggataatgatgacgggagaCggagtaacagcaaggcttgt	15	5	0	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr11:7334771C>T	uc001mfe.2	+	3	880	c.643C>T	c.(643-645)CGG>TGG	p.R215W	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	215	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TGACGGGAGACGGAGTAACAG	0.398													T	7334771	T	T	7334771	3	4	187	1	0	0	0	0	1	0	0	0	15478	527	19	1	653	1	SYT9	11	7334771	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	7020429	7334771	127671745	49	13286											
OR5J2	282775	broad.mit.edu	37	chr11	55944236	55944236	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaatctgggcatgatcctctTaatccaaatcacctccaaac	5	13	3	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr11:55944236T>A	uc010rjb.1	+	1	143	c.143T>A	c.(142-144)TTA>TAA	p.L48*		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					ATGATCCTCTTAATCCAAATC	0.428													A	55944236	A	A	55944236	4	1	187	1	0	0	0	0	0	1	0	0	11165	1764	61	5	145	5	OR5J2	11	55944236	Nonsense_Mutation	SNP	T	TCGA-27-1835-01A-01D-1494-08	48609465	55944236	79062280	50	13287											
POLA2	23649	broad.mit.edu	37	chr11	65048610	65048610	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ttaaggaatattctctgtttCctggacaggtgagattggag	12	5	1	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr11:65048610C>A	uc001odj.2	+	8	1234	c.892C>A	c.(892-894)CCT>ACT	p.P298T	POLA2_uc010rod.1_Missense_Mutation_p.P90T|POLA2_uc001odk.2_5'UTR	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	298					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	TTCTCTGTTTCCTGGACAGGT	0.512													A	65048610	A	A	65048610	3	1	187	1	0	0	0	0	1	0	0	0	12188	855	30	5	922	5	POLA2	11	65048610	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	9104374	65048610	69957906	51	13288											
OR10G7	390265	broad.mit.edu	37	chr11	123909464	123909464	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccgcttggggacaccaagGtcatcagcattttgggcacc	12	12	2	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr11:123909464G>A	uc001pzq.1	-	1	245	c.245C>T	c.(244-246)ACC>ATC	p.T82I		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GGACACCAAGGTCATCAGCAT	0.532													A	123909464	A	A	123909464	3	1	187	1	0	0	0	0	1	0	0	0	10902	1261	44	3	694	3	OR10G7	11	123909464	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	58860854	123909464	11097052	52	13289											
IQSEC3	440073	broad.mit.edu	37	chr12	248252	248254	+	In_Frame_Del	DEL	GAG	-	-													cccccaaaacagaggaggaaGaggaggaggaggagacggcg							TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr12:248252_248254delGAG	uc001qhw.1	+	1	820_822	c.814_816delGAG	c.(814-816)GAGdel	p.E276del	IQSEC3_uc001qhu.1_In_Frame_Del_p.E276del|IQSEC3_uc001qht.1_In_Frame_Del_p.E361del|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	579	Poly-Glu.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		Agaggaggaagaggaggaggagg	0.586													-	248254	-	-	248252	7	5	187	1	0	1	0	1	0	0	0	0	7819	943	33	0	1737	0	IQSEC3	12	248252	In_Frame_Del	DEL	GAG	TCGA-27-1835-01A-01D-1494-08		248252	133603643	53	13290											
C3AR1	719	broad.mit.edu	37	chr12	8211864	8211864	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttgtggtagctcagactcGtagaaggaattgctagaagc	12	8	1	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr12:8211864G>A	uc001qtv.1	-	2	1010	c.918C>T	c.(916-918)TAC>TAT	p.Y306Y		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	306	Extracellular (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		GCTCAGACTCGTAGAAGGAAT	0.438													A	8211864	A	A	8211864	2	1	187	1	0	0	0	0	0	0	0	1	2205	1140	40	1		1	C3AR1	12	8211864	Silent	SNP	G	TCGA-27-1835-01A-01D-1494-08	7963612	8211864	125640031	54	13291											
C12orf51	283450	broad.mit.edu	37	chr12	112622744	112622744	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgggcttgctgcctccgatGctgagcacggtggggtccga	16	12	0	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr12:112622744G>A	uc009zwc.2	-	54	8778	c.8760C>T	c.(8758-8760)AGC>AGT	p.S2920S		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TGCCTCCGATGCTGAGCACGG	0.627													A	112622744	A	A	112622744	2	1	187	1	0	0	0	0	0	0	0	1	1696	1310	46	3		3	C12orf51	12	112622744	Silent	SNP	G	TCGA-27-1835-01A-01D-1494-08	104410880	112622744	21229151	55	13292											
DDX54	79039	broad.mit.edu	37	chr12	113600992	113600992	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatgtagaattcctggtcccGctgccgggcctcctccctcc	10	17	0	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr12:113600992G>T	uc001tup.2	-	16	2054	c.2026C>A	c.(2026-2028)CGG>AGG	p.R676R	DDX54_uc001tuq.3_Silent_p.R676R	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	676					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						TCCTGGTCCCGCTGCCGGGCC	0.667													T	113600992	T	T	113600992	2	4	187	1	0	0	0	0	0	0	0	1	4372	1086	38	5		5	DDX54	12	113600992	Silent	SNP	G	TCGA-27-1835-01A-01D-1494-08	978248	113600992	20250903	56	13293											
LTBP2	4053	broad.mit.edu	37	chr14	74991895	74991895	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cttcctgtatctctgcaatcCcctgttcaggcattggtggg	10	12	2	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr14:74991895C>G	uc001xqa.2	-	15	2849	c.2462G>C	c.(2461-2463)GGG>GCG	p.G821A		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	821					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CTCTGCAATCCCCTGTTCAGG	0.612													G	74991895	G	G	74991895	3	3	187	1	0	0	0	0	1	0	0	0	9074	623	22	5	3091	5	LTBP2	14	74991895	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08		74991895	32357645	57	13294			1	36		2	2	33	C		8.062541e-05
LTBP2	4053	broad.mit.edu	37	chr14	74991927	74991927	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	attggtggggttgtggcattCcctgtggaggagagagggga	20	4	0	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr14:74991927C>G	uc001xqa.2	-	15	2817	c.2430G>C	c.(2428-2430)GGG>GGC	p.G810G		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	810					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TTGTGGCATTCCCTGTGGAGG	0.597													G	74991927	G	G	74991927	2	3	187	1	0	0	0	0	0	0	0	1	9074	869	30	5		5	LTBP2	14	74991927	Silent	SNP	C	TCGA-27-1835-01A-01D-1494-08	32	74991927	32357613	58	13295			1	36		2	2	33	C		8.062541e-05
STON2	85439	broad.mit.edu	37	chr14	81744671	81744671	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aagaaagcactgaaagggttGataggggagggctgtacatc	15	5	0	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr14:81744671G>C	uc010tvu.1	-	4	1185	c.984C>G	c.(982-984)ATC>ATG	p.I328M	STON2_uc001xvk.1_Missense_Mutation_p.I328M|STON2_uc010tvt.1_Missense_Mutation_p.I125M	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	328					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TGAAAGGGTTGATAGGGGAGG	0.512													C	81744671	C	C	81744671	3	2	187	1	0	0	0	0	1	0	0	0	15317	1280	45	5	1739	5	STON2	14	81744671	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	6752744	81744671	25604869	59	13296											
C14orf109	26175	broad.mit.edu	37	chr14	93651787	93651787	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	attattcagagctgagtgacTctttaacgcttgccgtggga	11	8	2	3			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr14:93651787T>A	uc010auo.2	+	1	413	c.55T>A	c.(55-57)TCT>ACT	p.S19T	MOAP1_uc001ybj.2_5'Flank|C14orf109_uc001ybk.3_Intron	NM_001098621	NP_001092091	Q8N6I4	CN109_HUMAN	hypothetical protein LOC26175 isoform 1	13						integral to membrane					0		all_cancers(154;0.11)|Acute lymphoblastic leukemia(33;0.0488)		Epithelial(152;0.176)|all cancers(159;0.197)|COAD - Colon adenocarcinoma(157;0.202)		GCTGAGTGACTCTTTAACGCT	0.502													A	93651787	A	A	93651787	3	1	187	1	0	0	0	0	1	0	0	0	1739	1551	54	5	57	5	C14orf109	14	93651787	Missense_Mutation	SNP	T	TCGA-27-1835-01A-01D-1494-08	11907116	93651787	13697753	60	13297											
RLTPR	146206	broad.mit.edu	37	chr16	67683828	67683828	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgaacgacgtggcccaggCgcagcgcagccgcccggaac	14	16	0	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr16:67683828C>T	uc002etn.2	+	21	2159	c.2039C>T	c.(2038-2040)GCG>GTG	p.A680V	RLTPR_uc010cel.1_Missense_Mutation_p.A673V|RLTPR_uc010vjr.1_Missense_Mutation_p.A644V	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	680	LRR 16.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GTGGCCCAGGCGCAGCGCAGC	0.647													T	67683828	T	T	67683828	3	4	187	1	0	0	0	0	1	0	0	0	13394	768	27	1	2121	1	RLTPR	16	67683828	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08		67683828	22670925	61	13298											
TP53	7157	broad.mit.edu	37	chr17	7578203	7578203	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggctcatagggcaccaccaCactatgtcgaaaagtgtttc	9	12	1	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr17:7578203C>T	uc002gim.2	-	6	840	c.646G>A	c.(646-648)GTG>ATG	p.V216M	TP53_uc002gig.1_Missense_Mutation_p.V216M|TP53_uc002gih.2_Missense_Mutation_p.V216M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V84M|TP53_uc010cng.1_Missense_Mutation_p.V84M|TP53_uc002gii.1_Missense_Mutation_p.V84M|TP53_uc010cnh.1_Missense_Mutation_p.V216M|TP53_uc010cni.1_Missense_Mutation_p.V216M|TP53_uc002gij.2_Missense_Mutation_p.V216M|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.V123M|TP53_uc002gio.2_Missense_Mutation_p.V84M|TP53_uc010vug.1_Missense_Mutation_p.V177M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	216	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> A (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> M (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V216M(49)|p.V216del(8)|p.0?(7)|p.V216L(7)|p.V216E(4)|p.V216G(3)|p.V216A(3)|p.V216fs*6(2)|p.V216fs*31(2)|p.H214fs*5(2)|p.K164_P219del(1)|p.V216fs*32(1)|p.V216fs*33(1)|p.S215fs*27(1)|p.S215fs*29(1)|p.V216fs*5(1)|p.V216_Y220delVVVPY(1)|p.D208_V216delDRNTFRHSV(1)|p.D208fs*1(1)|p.V216fs*28(1)|p.S215fs*31(1)|p.S215_V216insX(1)|p.T211fs*28(1)|p.D207_V216del10(1)|p.S215_V218>R(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACCACCACACTATGTCGA	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578203	T	T	7578203	3	4	187	1	0	0	0	0	1	0	0	0	16378	478	17	3	648	3	TP53	17	7578203	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08		7578203	73617007	62	13299											
PLXDC1	57125	broad.mit.edu	37	chr17	37265501	37265501	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggcgactggggcactcacCgaagcctgccggtgggtgtt	16	12	1	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr17:37265501C>T	uc002hrg.2	-	3	611	c.399G>A	c.(397-399)TCG>TCA	p.S133S	PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	133	Extracellular (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						GGGCACTCACCGAAGCCTGCC	0.657													T	37265501	T	T	37265501	2	4	187	1	0	0	0	0	0	0	0	1	12117	666	23	2		2	PLXDC1	17	37265501	Silent	SNP	C	TCGA-27-1835-01A-01D-1494-08	29687298	37265501	43929709	63	13300											
SCN4A	6329	broad.mit.edu	37	chr17	62036660	62036660	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagcacagacagtccctgtaCgttggccaggcctagctcta	10	13	1	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr17:62036660C>T	uc002jds.1	-	12	2061	c.1984G>A	c.(1984-1986)GTA>ATA	p.V662I		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	662	II.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	AGTCCCTGTACGTTGGCCAGG	0.592													T	62036660	T	T	62036660	3	4	187	1	0	0	0	0	1	0	0	0	13920	536	19	1	3578	1	SCN4A	17	62036660	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	24771159	62036660	19158550	64	13301											
PALM	5064	broad.mit.edu	37	chr19	746653	746653	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtggtcatcgaagacgcgGctgagcccaaggagcctgca	15	11	1	2			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr19:746653G>A	uc002lpm.1	+	9	1197	c.1003G>A	c.(1003-1005)GCT>ACT	p.A335T	PALM_uc002lpn.1_Missense_Mutation_p.A291T|PALM_uc010xfu.1_Missense_Mutation_p.A200T	NM_002579	NP_002570	O75781	PALM_HUMAN	paralemmin isoform 1	335					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		CGAAGACGCGGCTGAGCCCAA	0.647													A	746653	A	A	746653	3	1	187	1	0	0	0	0	1	0	0	0	11408	1203	42	3	1037	3	PALM	19	746653	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08		746653	58382330	65	13302											
SAFB2	9667	broad.mit.edu	37	chr19	5587954	5587954	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggcgcgtgcctggtgctcctCtagccgctggttgtgctctc	14	14	2	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr19:5587954C>T	uc002mcd.2	-	19	2775	c.2563G>A	c.(2563-2565)GAG>AAG	p.E855K		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	855	Interacts with SAFB1.|Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TGGTGCTCCTCTAGCCGCTGG	0.652													T	5587954	T	T	5587954	3	4	187	1	0	0	0	0	1	0	0	0	13807	922	32	3	310	3	SAFB2	19	5587954	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	4841301	5587954	53541029	66	13303											
ANGPT4	51378	broad.mit.edu	37	chr20	860425	860425	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagttccgctgaaaattcaCggtgccattctcacggcgct	9	14	2	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr20:860425C>T	uc002wei.2	-	6	1121	c.1018G>A	c.(1018-1020)GTG>ATG	p.V340M	ANGPT4_uc010zpn.1_Missense_Mutation_p.V334M	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	340	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						TGAAAATTCACGGTGCCATTC	0.617													T	860425	T	T	860425	3	4	187	1	0	0	0	0	1	0	0	0	612	536	19	1	509	1	ANGPT4	20	860425	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08		860425	62165095	67	13304											
PTPRT	11122	broad.mit.edu	37	chr20	41306569	41306569	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtacccccctcacctggtcGtgtgaggagcactcggatct	11	15	2	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr20:41306569G>A	uc002xkg.2	-	7	1274	c.1090C>T	c.(1090-1092)CGA>TGA	p.R364*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.R364*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	364	Extracellular (Potential).|Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCACCTGGTCGTGTGAGGAGC	0.562													A	41306569	A	A	41306569	4	1	187	1	0	0	0	0	0	1	0	0	12812	1153	40	1	3396	1	PTPRT	20	41306569	Nonsense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	40446144	41306569	21718951	68	13305											
MATN4	8785	broad.mit.edu	37	chr20	43927042	43927042	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcggtgccgtagcgacccagAgggaactcggtgcgcacgcg	17	13	0	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr20:43927042A>T	uc002xnn.2	-	7	1381	c.1194T>A	c.(1192-1194)CCT>CCA	p.P398P	MATN4_uc002xno.2_Silent_p.P357P|MATN4_uc002xnp.2_Silent_p.P316P|MATN4_uc010zwr.1_Silent_p.P346P|MATN4_uc002xnr.1_Silent_p.P398P	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	439	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				AGCGACCCAGAGGGAACTCGG	0.662													T	43927042	T	T	43927042	2	4	187	1	0	0	0	0	0	0	0	1	9336	291	11	5		5	MATN4	20	43927042	Silent	SNP	A	TCGA-27-1835-01A-01D-1494-08	2620473	43927042	19098478	69	13306											
MATN4	8785	broad.mit.edu	37	chr20	43933002	43933002	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcgcgctgcacccccaccGcgtaaatttcaatgccgcgg	10	18	1	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr20:43933002G>A	uc002xnn.2	-	3	696	c.509C>T	c.(508-510)GCG>GTG	p.A170V	MATN4_uc002xno.2_Missense_Mutation_p.A170V|MATN4_uc002xnp.2_Missense_Mutation_p.A170V|MATN4_uc010zwr.1_Missense_Mutation_p.A118V|MATN4_uc002xnr.1_Missense_Mutation_p.A170V|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	170	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				CACCCCCACCGCGTAAATTTC	0.706													A	43933002	A	A	43933002	3	1	187	1	0	0	0	0	1	0	0	0	9336	1087	38	1	1268	1	MATN4	20	43933002	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	5960	43933002	19092518	70	13307											
MMP9	4318	broad.mit.edu	37	chr20	44641083	44641083	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggatacagtttgttcctcGtggcggcgcatgagttcggc	14	10	0	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr20:44641083G>A	uc002xqz.2	+	8	1211	c.1192G>A	c.(1192-1194)GTG>ATG	p.V398M		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	398					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TTTGTTCCTCGTGGCGGCGCA	0.662													A	44641083	A	A	44641083	3	1	187	1	0	0	0	0	1	0	0	0	9669	1145	40	1	1222	1	MMP9	20	44641083	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08	708081	44641083	18384437	71	13308											
MIOX	55586	broad.mit.edu	37	chr22	50928230	50928230	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccggacgtggacaagctgcGgccctactaccaggggctca	14	14	1	0	rs140377157	byFrequency	TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chr22:50928230G>A	uc003bll.1	+	10	917	c.803G>A	c.(802-804)CGG>CAG	p.R268Q	MIOX_uc003blm.1_Silent_p.A263A|MIOX_uc003bln.1_Silent_p.A224A	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	268					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GACAAGCTGCGGCCCTACTAC	0.662													A	50928230	A	A	50928230	3	1	187	1	0	0	0	0	1	0	0	0	9590	1116	39	2	841	2	MIOX	22	50928230	Missense_Mutation	SNP	G	TCGA-27-1835-01A-01D-1494-08		50928230	376336	72	13309											
EIF1AX	1964	broad.mit.edu	37	chrX	20148634	20148634	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacaaggtacatctacttacGtcatcaatatcttcatcatc	3	12	6	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chrX:20148634G>A	uc004czt.2	-	6	637	c.429C>T	c.(427-429)GAC>GAT	p.D143D		NM_001412	NP_001403	P47813	IF1AX_HUMAN	X-linked eukaryotic translation initiation	143						cytosol	translation initiation factor activity			ovary(1)	1						ATCTACTTACGTCATCAATAT	0.338													A	20148634	A	A	20148634	2	1	187	1	0	0	0	0	0	0	0	1	4992	1159	40	1		1	EIF1AX	23	20148634	Silent	SNP	G	TCGA-27-1835-01A-01D-1494-08		20148634	135121926	73	13310											
ZNF674	641339	broad.mit.edu	37	chrX	46359485	46359485	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gtatgaattctctgatgtttGatgagagttgacttcctact	9	6	1	5			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chrX:46359485G>T	uc004dgr.2	-	6	1766	c.1539C>A	c.(1537-1539)ATC>ATA	p.I513I	ZNF674_uc011mlg.1_Silent_p.I507I	NM_001039891	NP_001034980	Q2M3X9	ZN674_HUMAN	zinc finger family member 674 isoform 1	513	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)	2						TCTGATGTTTGATGAGAGTTG	0.398													T	46359485	T	T	46359485	2	4	187	1	0	0	0	0	0	0	0	1	18078	1280	45	5		5	ZNF674	23	46359485	Silent	SNP	G	TCGA-27-1835-01A-01D-1494-08	26210851	46359485	108911075	74	13311											
ACRC	93953	broad.mit.edu	37	chrX	70830591	70830591	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaactgctggcttatgcAgcactggtgagatgtggtac	13	7	0	2			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chrX:70830591A>G	uc004eae.2	+	11	2173	c.1672A>G	c.(1672-1674)AGC>GGC	p.S558G	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	558						nucleus				ovary(3)	3	Renal(35;0.156)					TGGCTTATGCAGCACTGGTGA	0.493													G	70830591	G	G	70830591	3	3	187	1	0	0	0	0	1	0	0	0	171	188	7	4	1710	4	ACRC	23	70830591	Missense_Mutation	SNP	A	TCGA-27-1835-01A-01D-1494-08	24471106	70830591	84439969	75	13312											
RPS4X	6191	broad.mit.edu	37	chrX	71492579	71492579	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcttcagcaatggtgaggCggataccctttcctcgggga	12	11	2	1			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chrX:71492579C>T	uc004ear.2	-	7	830	c.734G>A	c.(733-735)CGC>CAC	p.R245H		NM_001007	NP_000998	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked X isoform	245					endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0	Renal(35;0.156)					AATGGTGAGGCGGATACCCTT	0.488													T	71492579	T	T	71492579	3	4	187	1	0	0	0	0	1	0	0	0	13645	768	27	1	61	1	RPS4X	23	71492579	Missense_Mutation	SNP	C	TCGA-27-1835-01A-01D-1494-08	661988	71492579	83777981	76	13313											
COL4A6	1288	broad.mit.edu	37	chrX	107407829	107407829	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagcacatgctctcaacttaCctcttggccctgccttcccc	5	19	2	0			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chrX:107407829C>A	uc004enw.3	-	40	4175	c.4072_splice	c.e40+1	p.G1358_splice	COL4A6_uc004env.3_Splice_Site_p.G1357_splice|COL4A6_uc011msn.1_Splice_Site_p.G1333_splice|COL4A6_uc010npk.2_Intron|COL4A6_uc010npj.2_5'Flank	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor						cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						TCTCAACTTACCTCTTGGCCC	0.592									Alport_syndrome_with_Diffuse_Leiomyomatosis				A	107407829	A	A	107407829	5	1	187	1	0	0	0	0	0	0	1	0	3695	521	18	5	1026	5	COL4A6	23	107407829	Splice_Site	SNP	C	TCGA-27-1835-01A-01D-1494-08	35915250	107407829	47862731	77	13314											
MAGEC2	51438	broad.mit.edu	37	chrX	141291591	141291591	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcctcaggaccaccaagaatCagagaagaggatgtggagaa	12	8	2	4			TCGA-27-1835-01A-01D-1494-08	TCGA-27-1835-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6d5fd73b-4cad-44ae-8c79-67f2b9d30328	e94c4f81-564e-4435-a308-6d27aa33bd82	g.chrX:141291591C>T	uc004fbu.1	-	3	531	c.183G>A	c.(181-183)CTG>CTA	p.L61L		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	61						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CACCAAGAATCAGAGAAGAGG	0.443										HNSCC(46;0.14)			T	141291591	T	T	141291591	2	4	187	1	0	0	0	0	0	0	0	1	9181	813	29	3		3	MAGEC2	23	141291591	Silent	SNP	C	TCGA-27-1835-01A-01D-1494-08	33883762	141291591	13978969	78	13315											
PTCH2	8643	broad.mit.edu	37	chr1	45288988	45288988	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagatggccccatcggtcaCgggggcaaatgtgtgctcaa	15	10	2	1	rs142187073	byFrequency	TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr1:45288988C>T	uc010olf.1	-	20	3196	c.3184G>A	c.(3184-3186)GTG>ATG	p.V1062M	PTCH2_uc010olg.1_Missense_Mutation_p.V760M	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	1062	Cytoplasmic (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					CCATCGGTCACGGGGGCAAAT	0.617									Basal_Cell_Nevus_syndrome				T	45288988	T	T	45288988	3	4	188	1	0	0	0	0	1	0	0	0	12731	536	19	1	459	1	PTCH2	1	45288988	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08		45288988	203961633	1	13316											
NRD1	4898	broad.mit.edu	37	chr1	52260179	52260179	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacttcagagttggcatcacCcttgttcagagctttcactt	8	11	4	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr1:52260179C>T	uc001ctc.3	-	26	3266	c.2944G>A	c.(2944-2946)GGT>AGT	p.G982S	NRD1_uc009vzb.2_Missense_Mutation_p.G677S|NRD1_uc001ctd.3_Missense_Mutation_p.G914S|NRD1_uc001cte.2_Missense_Mutation_p.G850S|NRD1_uc001ctf.2_Missense_Mutation_p.G914S|NRD1_uc010ong.1_RNA	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	913					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						TTGGCATCACCCTTGTTCAGA	0.547													T	52260179	T	T	52260179	3	4	188	1	0	0	0	0	1	0	0	0	10645	623	22	3	747	3	NRD1	1	52260179	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	6971191	52260179	196990442	2	13317											
HIPK1	204851	broad.mit.edu	37	chr1	114500841	114500841	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggtgtttccttgcagcctGgaaccacccagatttgcact	10	12	0	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr1:114500841G>A	uc001eem.2	+	8	2070	c.1909G>A	c.(1909-1911)GGA>AGA	p.G637R	HIPK1_uc001eel.2_Missense_Mutation_p.G637R|HIPK1_uc001een.2_Missense_Mutation_p.G637R|HIPK1_uc001eeo.2_Missense_Mutation_p.G263R|HIPK1_uc001eep.2_Missense_Mutation_p.G243R	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	637					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTGCAGCCTGGAACCACCCA	0.463													A	114500841	A	A	114500841	3	1	188	1	0	0	0	0	1	0	0	0	7116	1349	47	3	1953	3	HIPK1	1	114500841	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	62240662	114500841	134749780	3	13318											
RYR2	6262	broad.mit.edu	37	chr1	237777379	237777379	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgacagagcaggaggaattgCtgaaatttcactatcacact	9	8	2	3			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr1:237777379C>T	uc001hyl.1	+	37	5071	c.4951C>T	c.(4951-4953)CTG>TTG	p.L1651L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1651	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAGGAATTGCTGAAATTTCA	0.463													T	237777379	T	T	237777379	2	4	188	1	0	0	0	0	0	0	0	1	13769	796	28	3		3	RYR2	1	237777379	Silent	SNP	C	TCGA-27-1836-01A-01D-1494-08	123276538	237777379	11473242	4	13319											
OR2T34	127068	broad.mit.edu	37	chr1	248737350	248737350	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaggccttcctgcggccggCggcagaattcatcctgtgga	13	13	1	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr1:248737350C>T	uc001iep.1	-	1	709	c.709G>A	c.(709-711)GCC>ACC	p.A237T		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGCGGCCGGCGGCAGAATTC	0.562													T	248737350	T	T	248737350	3	4	188	1	0	0	0	0	1	0	0	0	11025	768	27	1	251	1	OR2T34	1	248737350	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	10959971	248737350	513271	5	13320											
IL1F6	27179	broad.mit.edu	37	chr2	113764258	113764258	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctacctgggcctgaatggaCtcaatctctgcctgatgtgt	10	11	3	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr2:113764258C>T	uc010yxr.1	+	3	208	c.208C>T	c.(208-210)CTC>TTC	p.L70F		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	70					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding				0						CCTGAATGGACTCAATCTCTG	0.512													T	113764258	T	T	113764258	3	4	188	1	0	0	0	0	1	0	0	0	7654	565	20	3	218	3	IL1F6	2	113764258	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08		113764258	129435115	6	13321											
ZAK	51776	broad.mit.edu	37	chr2	174131096	174131096	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttcagagaggggtcgatactCagacagaagcaggaacaaat	12	7	2	3			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr2:174131096C>T	uc002uhz.2	+	20	2221	c.2021C>T	c.(2020-2022)TCA>TTA	p.S674L	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	674					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			GGTCGATACTCAGACAGAAGC	0.448													T	174131096	T	T	174131096	3	4	188	1	0	0	0	0	1	0	0	0	17509	838	29	3	2480	3	ZAK	2	174131096	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	60366838	174131096	69068277	7	13322											
ACADL	33	broad.mit.edu	37	chr2	211070506	211070506	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaacatcacttaatgacccAttactgatgaacacctgcaa	4	12	1	3			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr2:211070506A>G	uc002vdz.3	-	6	846	c.618T>C	c.(616-618)AAT>AAC	p.N206N		NM_001608	NP_001599	P28330	ACADL_HUMAN	long-chain acyl-CoA dehydrogenase precursor	206					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity				0		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		TTAATGACCCATTACTGATGA	0.388													G	211070506	G	G	211070506	2	3	188	1	0	0	0	0	0	0	0	1	112	214	8	4		4	ACADL	2	211070506	Silent	SNP	A	TCGA-27-1836-01A-01D-1494-08	36939410	211070506	32128867	8	13323											
NKTR	4820	broad.mit.edu	37	chr3	42676817	42676817	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaatgcagagattaagagcAtatagaccacctagtggaga	11	6	0	4	rs142015233		TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr3:42676817A>G	uc003clo.2	+	12	1269	c.1122A>G	c.(1120-1122)GCA>GCG	p.A374A	NKTR_uc003clm.1_Silent_p.A121A|NKTR_uc003clp.2_Silent_p.A121A|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Silent_p.A264A|NKTR_uc003clr.1_Silent_p.A121A|NKTR_uc003cls.2_Silent_p.A74A	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	374					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GATTAAGAGCATATAGACCAC	0.388													G	42676817	G	G	42676817	2	3	188	1	0	0	0	0	0	0	0	1	10448	204	8	4		4	NKTR	3	42676817	Silent	SNP	A	TCGA-27-1836-01A-01D-1494-08		42676817	155345613	9	13324											
KBTBD8	84541	broad.mit.edu	37	chr3	67054666	67054666	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aattgttggacgactgtttgCgcgatgccagttgcaatgga	13	7	0	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr3:67054666C>T	uc003dmy.2	+	3	1328	c.1275C>T	c.(1273-1275)TGC>TGT	p.C425C	KBTBD8_uc011bfv.1_Intron	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	425	Kelch 2.									ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		CGACTGTTTGCGCGATGCCAG	0.413													T	67054666	T	T	67054666	2	4	188	1	0	0	0	0	0	0	0	1	7999	776	27	1		1	KBTBD8	3	67054666	Silent	SNP	C	TCGA-27-1836-01A-01D-1494-08	24377849	67054666	130967764	10	13325											
ROBO1	6091	broad.mit.edu	37	chr3	78734960	78734960	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatttaaagtctggcagatGtaataaccaacatcagatcg	7	8	2	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr3:78734960G>A	uc003dqe.2	-	10	1486	c.1278C>T	c.(1276-1278)TAC>TAT	p.Y426Y	ROBO1_uc003dqb.2_Silent_p.Y387Y|ROBO1_uc003dqc.2_Silent_p.Y390Y|ROBO1_uc003dqd.2_Silent_p.Y390Y|ROBO1_uc010hoh.2_5'UTR|ROBO1_uc003dqf.1_Silent_p.Y105Y	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	426	Extracellular (Potential).|Ig-like C2-type 4.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TCTGGCAGATGTAATAACCAA	0.393													A	78734960	A	A	78734960	2	1	188	1	0	0	0	0	0	0	0	1	13513	1372	48	3		3	ROBO1	3	78734960	Silent	SNP	G	TCGA-27-1836-01A-01D-1494-08	11680294	78734960	119287470	11	13326											
DNAJB8	165721	broad.mit.edu	37	chr3	128181904	128181904	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcacggtcatacagggagCgtttcttggagtcagacaga	13	9	3	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr3:128181904C>T	uc003ekk.1	-	3	1846	c.185G>A	c.(184-186)CGC>CAC	p.R62H	uc003ekl.1_5'Flank	NM_153330	NP_699161	Q8NHS0	DNJB8_HUMAN	DnaJ homolog, subfamily B, member 8	62	J.				protein folding		heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(114;0.177)		ATACAGGGAGCGTTTCTTGGA	0.602													T	128181904	T	T	128181904	3	4	188	1	0	0	0	0	1	0	0	0	4626	768	27	1	517	1	DNAJB8	3	128181904	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	49446944	128181904	69840526	12	13327											
ARL14	80117	broad.mit.edu	37	chr3	160395695	160395695	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaagaggagacactttggcGttcttcaagcagaactgagg	12	8	3	4			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr3:160395695G>A	uc003fdq.2	+	1	748	c.561G>A	c.(559-561)GCG>GCA	p.A187A		NM_025047	NP_079323	Q8N4G2	ARL14_HUMAN	ADP-ribosylation factor-like 14	187					small GTPase mediated signal transduction	intracellular	GTP binding				0			Lung(72;7.02e-05)|LUSC - Lung squamous cell carcinoma(72;7.23e-05)			ACACTTTGGCGTTCTTCAAGC	0.473													A	160395695	A	A	160395695	2	1	188	1	0	0	0	0	0	0	0	1	930	1132	40	1		1	ARL14	3	160395695	Silent	SNP	G	TCGA-27-1836-01A-01D-1494-08	32213791	160395695	37626735	13	13328											
KNG1	3827	broad.mit.edu	37	chr3	186459456	186459456	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggattcaggaaaagaacaagGgcatactcgtagacatgact	11	7	1	3			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr3:186459456G>A	uc011bsa.1	+	10	1483	c.1271G>A	c.(1270-1272)GGG>GAG	p.G424E	KNG1_uc003fqr.2_Intron	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	424	|His-rich.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	AAAGAACAAGGGCATACTCGT	0.458													A	186459456	A	A	186459456	3	1	188	1	0	0	0	0	1	0	0	0	8427	1232	43	3	1309	3	KNG1	3	186459456	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	26063761	186459456	11562974	14	13329											
UGT2B10	7365	broad.mit.edu	37	chr4	69681966	69681966	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctcttaaacttgaagtttatCctacatctttaactaaaact	2	9	2	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr4:69681966C>A	uc003hee.2	+	1	254	c.229C>A	c.(229-231)CCT>ACT	p.P77T	UGT2B10_uc011cam.1_Missense_Mutation_p.P77T	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	77					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TGAAGTTTATCCTACATCTTT	0.348													A	69681966	A	A	69681966	3	1	188	1	0	0	0	0	1	0	0	0	16953	855	30	5	231	5	UGT2B10	4	69681966	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08		69681966	121472310	15	13330											
TLR2	7097	broad.mit.edu	37	chr4	154625962	154625962	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaaggaagcccaggaaagctCccagcaggaacatctgctat	10	11	1	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr4:154625962C>T	uc003inq.2	+	3	2122	c.1903C>T	c.(1903-1905)CCC>TCC	p.P635S	TLR2_uc003inr.2_Missense_Mutation_p.P635S|TLR2_uc003ins.2_Missense_Mutation_p.P635S	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	635	Cytoplasmic (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				CAGGAAAGCTCCCAGCAGGAA	0.537													T	154625962	T	T	154625962	3	4	188	1	0	0	0	0	1	0	0	0	15948	855	30	3	1905	3	TLR2	4	154625962	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	84943996	154625962	36528314	16	13331											
CDH9	1007	broad.mit.edu	37	chr5	26902589	26902589	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttttcaaagtacttactttaTtaaattgttcctggcatctg	5	7	2	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr5:26902589T>A	uc003jgs.1	-	7	1418	c.1249A>T	c.(1249-1251)ATA>TTA	p.I417L		NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	417	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ACTTACTTTATTAAATTGTTC	0.308													A	26902589	A	A	26902589	3	1	188	1	0	0	0	0	1	0	0	0	3117	1493	52	5	1144	5	CDH9	5	26902589	Missense_Mutation	SNP	T	TCGA-27-1836-01A-01D-1494-08		26902589	154012671	17	13332											
SPEF2	79925	broad.mit.edu	37	chr5	35641735	35641735	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggagatgcaaaccatgcaaCgtctgacaaatttaagactt	8	8	1	3			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr5:35641735C>T	uc003jjo.2	+	3	475	c.364C>T	c.(364-366)CGT>TGT	p.R122C	SPEF2_uc003jjn.1_Missense_Mutation_p.R122C|SPEF2_uc003jjq.3_Missense_Mutation_p.R122C	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	122					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AACCATGCAACGTCTGACAAA	0.358													T	35641735	T	T	35641735	3	4	188	1	0	0	0	0	1	0	0	0	15034	536	19	1	374	1	SPEF2	5	35641735	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	8739146	35641735	145273525	18	13333											
EFNA5	1946	broad.mit.edu	37	chr5	106763058	106763058	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atctcttgaaccctttggaaGtgtggtcgcaggcactgtag	12	9	1	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr5:106763058G>C	uc003kol.2	-	2	560	c.278C>G	c.(277-279)ACT>AGT	p.T93S	EFNA5_uc010jbr.1_Missense_Mutation_p.T93S	NM_001962	NP_001953	P52803	EFNA5_HUMAN	ephrin-A5 precursor	93					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding				0		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		CCCTTTGGAAGTGTGGTCGCA	0.488													C	106763058	C	C	106763058	3	2	188	1	0	0	0	0	1	0	0	0	4954	1029	36	5	424	5	EFNA5	5	106763058	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	71121323	106763058	74152202	19	13334											
KIF4B	285643	broad.mit.edu	37	chr5	154396474	154396474	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tatctccagactcttcttttGaatatatcccacctaagcca	3	13	3	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr5:154396474G>A	uc010jih.1	+	1	3215	c.3055G>A	c.(3055-3057)GAA>AAA	p.E1019K		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1019	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CTCTTCTTTTGAATATATCCC	0.403													A	154396474	A	A	154396474	3	1	188	1	0	0	0	0	1	0	0	0	8304	1291	45	3	3057	3	KIF4B	5	154396474	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	47633416	154396474	26518786	20	13335											
SLIT3	6586	broad.mit.edu	37	chr5	168176560	168176560	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggcacctagggttcccaCtgacgatccgcctcttcctc	8	17	2	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr5:168176560C>T	uc003mab.2	-	19	2474	c.2054G>A	c.(2053-2055)AGT>AAT	p.S685N	SLIT3_uc010jjg.2_Missense_Mutation_p.S685N	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	685	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGGTTCCCACTGACGATCCG	0.557													T	168176560	T	T	168176560	3	4	188	1	0	0	0	0	1	0	0	0	14741	565	20	3	2589	3	SLIT3	5	168176560	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	13780086	168176560	12738700	21	13336											
KIF13A	63971	broad.mit.edu	37	chr6	17788096	17788097	+	Frame_Shift_Del	DEL	AA	-	-													acctctcccttacgcagtttAagtcttcttcctaacatcag							TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr6:17788096_17788097delAA	uc003ncg.3	-	27	3376_3377	c.3271_3272delTT	c.(3271-3273)TTAfs	p.L1091fs	KIF13A_uc003ncf.2_Frame_Shift_Del_p.L1078fs|KIF13A_uc003nch.3_Frame_Shift_Del_p.L1091fs|KIF13A_uc003nci.3_Frame_Shift_Del_p.L1078fs	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1091					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TACGCAGTTTAAGTCTTCTTCC	0.366													-	17788097	-	-	17788096	7	5	188	1	0	1	0	1	0	0	0	0	8274	372	13	0	2222	0	KIF13A	6	17788096	Frame_Shift_Del	DEL	AA	TCGA-27-1836-01A-01D-1494-08		17788096	153326971	22	13337											
COL11A2	1302	broad.mit.edu	37	chr6	33143356	33143356	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccctcatcccatcaccttctCgcccatgagccctgggggcc	8	20	3	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr6:33143356C>T	uc003ocx.1	-	30	2599	c.2371G>A	c.(2371-2373)GAG>AAG	p.E791K	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.E705K|COL11A2_uc003ocz.1_Missense_Mutation_p.E684K	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	791	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						ATCACCTTCTCGCCCATGAGC	0.657													T	33143356	T	T	33143356	3	4	188	1	0	0	0	0	1	0	0	0	3668	893	31	2	2987	2	COL11A2	6	33143356	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	15355260	33143356	137971711	23	13338											
GPR31	2853	broad.mit.edu	37	chr6	167571202	167571202	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccacaccctgacccggaacaGgaaggtccacagcgccaccg	10	18	0	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr6:167571202G>C	uc011egq.1	-	1	118	c.118C>G	c.(118-120)CTG>GTG	p.L40V		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	40	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		ACCCGGAACAGGAAGGTCCAC	0.662													C	167571202	C	C	167571202	3	2	188	1	0	0	0	0	1	0	0	0	6687	991	35	5	844	5	GPR31	6	167571202	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	134427846	167571202	3543865	24	13339											
TNKS	8658	broad.mit.edu	37	chr8	9565981	9565981	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcattaatttcaaacaaccGcagtctcatgaaacagcact	4	11	3	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr8:9565981G>A	uc003wss.2	+	9	1562	c.1557G>A	c.(1555-1557)CCG>CCA	p.P519P	TNKS_uc011kwv.1_Silent_p.P519P|TNKS_uc011kww.1_Silent_p.P282P	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	519					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		TCAAACAACCGCAGTCTCATG	0.328													A	9565981	A	A	9565981	2	1	188	1	0	0	0	0	0	0	0	1	16316	1074	38	1		1	TNKS	8	9565981	Silent	SNP	G	TCGA-27-1836-01A-01D-1494-08		9565981	136798041	25	13340											
KIAA1429	25962	broad.mit.edu	37	chr8	95531632	95531632	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttgtggcttgcagcacaccAgggtgagcacttgttactgg	13	9	0	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr8:95531632A>G	uc003ygo.1	-	9	2107	c.2094T>C	c.(2092-2094)CCT>CCC	p.P698P	KIAA1429_uc003ygp.2_Silent_p.P698P|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	698					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GCAGCACACCAGGGTGAGCAC	0.388													G	95531632	G	G	95531632	2	3	188	1	0	0	0	0	0	0	0	1	8231	175	7	4		4	KIAA1429	8	95531632	Silent	SNP	A	TCGA-27-1836-01A-01D-1494-08	85965651	95531632	50832390	26	13341											
FOXH1	8928	broad.mit.edu	37	chr8	145700407	145700407	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgaccgcccagaagttgccCttggcctggggctttgcagg	14	13	0	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr8:145700407C>T	uc003zdc.2	-	3	891	c.312G>A	c.(310-312)AAG>AAA	p.K104K		NM_003923	NP_003914	O75593	FOXH1_HUMAN	forkhead box H1	104	Fork-head.				axial mesoderm development|blood vessel development|cell migration involved in gastrulation|embryonic heart tube anterior/posterior pattern formation|floor plate formation|heart looping|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|specification of organ position|transforming growth factor beta receptor signaling pathway	activin responsive factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|R-SMAD binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.76e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AGAAGTTGCCCTTGGCCTGGG	0.687													T	145700407	T	T	145700407	2	4	188	1	0	0	0	0	0	0	0	1	6008	680	24	3		3	FOXH1	8	145700407	Silent	SNP	C	TCGA-27-1836-01A-01D-1494-08	50168775	145700407	663615	27	13342											
KIAA1539	80256	broad.mit.edu	37	chr9	35108147	35108147	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtagaccccgggggatgtcGccccccctgctgggctgtag	16	14	0	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr9:35108147G>A	uc003zwl.2	-	3	450	c.125C>T	c.(124-126)GCG>GTG	p.A42V	KIAA1539_uc003zwm.2_Missense_Mutation_p.A42V|KIAA1539_uc003zwn.2_5'UTR|KIAA1539_uc003zwo.2_Missense_Mutation_p.A42V|KIAA1539_uc003zwp.1_Missense_Mutation_p.A42V|KIAA1539_uc010mkk.1_RNA	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	42						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GGGGGATGTCGCCCCCCCTGC	0.652													A	35108147	A	A	35108147	3	1	188	1	0	0	0	0	1	0	0	0	8242	1087	38	1	1519	1	KIAA1539	9	35108147	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08		35108147	106105284	28	13343											
FAM102A	399665	broad.mit.edu	37	chr9	130710434	130710434	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccccactgctggtcccacCacccttacacgtcagctgca	7	20	1	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr9:130710434C>T	uc004bsx.1	-	6	611	c.532G>A	c.(532-534)GGT>AGT	p.G178S	FAM102A_uc004bsw.1_Missense_Mutation_p.G36S|FAM102A_uc004bsy.1_5'UTR	NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	178	Ser-rich.									ovary(1)	1						CTGGTCCCACCACCCTTACAC	0.612													T	130710434	T	T	130710434	3	4	188	1	0	0	0	0	1	0	0	0	5382	594	21	3	646	3	FAM102A	9	130710434	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	95602287	130710434	10502997	29	13344											
LAMC3	10319	broad.mit.edu	37	chr9	133947006	133947006	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctaccagggccatcacctgCttccaggtacagcaggagcg	11	14	2	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr9:133947006C>T	uc004caa.1	+	18	3303	c.3205C>T	c.(3205-3207)CTT>TTT	p.L1069F		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1069	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CCATCACCTGCTTCCAGGTAC	0.672													T	133947006	T	T	133947006	3	4	188	1	0	0	0	0	1	0	0	0	8616	797	28	3	3275	3	LAMC3	9	133947006	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	3236572	133947006	7266425	30	13345											
MUC2	4583	broad.mit.edu	37	chr11	1094855	1094855	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcctgaacgacacctactaCgcaccaggtactcaggctgt	9	14	1	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr11:1094855C>T	uc001lsx.1	+	34	13056	c.13029C>T	c.(13027-13029)TAC>TAT	p.Y4343Y		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4343						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ACACCTACTACGCACCAGGTA	0.607													T	1094855	T	T	1094855	2	4	188	1	0	0	0	0	0	0	0	1	9975	547	19	1		1	MUC2	11	1094855	Silent	SNP	C	TCGA-27-1836-01A-01D-1494-08		1094855	133911661	31	13346											
SLC22A10	387775	broad.mit.edu	37	chr11	63071595	63071595	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagaaatgcagaccctgcGtgtggctttggcatgtctgg	14	10	1	2	rs112720090		TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr11:63071595G>A	uc009yor.2	+	8	1509	c.1301G>A	c.(1300-1302)CGT>CAT	p.R434H	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_Missense_Mutation_p.V228M	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	434	Cytoplasmic (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						CAGACCCTGCGTGTGGCTTTG	0.453													A	63071595	A	A	63071595	3	1	188	1	0	0	0	0	1	0	0	0	14441	1145	40	1	1331	1	SLC22A10	11	63071595	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	61976740	63071595	71934921	32	13347											
CABP4	57010	broad.mit.edu	37	chr11	67223870	67223870	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accctgggctacatgcccacCgagatggagctcctggaggt	13	13	0	1	rs139927588		TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr11:67223870C>T	uc001olo.2	+	3	575	c.498C>T	c.(496-498)ACC>ACT	p.T166T	CABP4_uc001oln.2_Silent_p.T61T	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	166	EF-hand 2.				visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			ACATGCCCACCGAGATGGAGC	0.652													T	67223870	T	T	67223870	2	4	188	1	0	0	0	0	0	0	0	1	2533	639	23	2		2	CABP4	11	67223870	Silent	SNP	C	TCGA-27-1836-01A-01D-1494-08	4152275	67223870	67782646	33	13348											
CACNB3	784	broad.mit.edu	37	chr12	49218469	49218469	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caggagatctgggaacccttCcagcctgagtgacattggca	12	11	1	3			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr12:49218469C>T	uc001rsl.1	+	5	626	c.425C>T	c.(424-426)TCC>TTC	p.S142F	CACNB3_uc010slx.1_Missense_Mutation_p.S129F|CACNB3_uc010sly.1_Missense_Mutation_p.S129F|CACNB3_uc010slz.1_Missense_Mutation_p.S141F|CACNB3_uc001rsk.1_5'UTR	NM_000725	NP_000716	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3	142					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0					Verapamil(DB00661)	GGGAACCCTTCCAGCCTGAGT	0.493													T	49218469	T	T	49218469	3	4	188	1	0	0	0	0	1	0	0	0	2554	855	30	3	443	3	CACNB3	12	49218469	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08		49218469	84633426	34	13349											
TP53	7157	broad.mit.edu	37	chr17	7578217	7578217	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaccacactatgtcgaaaaGtgtttctgtcatccaaatac	5	12	2	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr17:7578217G>A	uc002gim.2	-	6	826	c.632C>T	c.(631-633)ACT>ATT	p.T211I	TP53_uc002gig.1_Missense_Mutation_p.T211I|TP53_uc002gih.2_Missense_Mutation_p.T211I|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.T79I|TP53_uc010cng.1_Missense_Mutation_p.T79I|TP53_uc002gii.1_Missense_Mutation_p.T79I|TP53_uc010cnh.1_Missense_Mutation_p.T211I|TP53_uc010cni.1_Missense_Mutation_p.T211I|TP53_uc002gij.2_Missense_Mutation_p.T211I|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.T118I|TP53_uc002gio.2_Missense_Mutation_p.T79I|TP53_uc010vug.1_Missense_Mutation_p.T172I	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	211	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in sporadic cancers; somatic mutation).|T -> I (in sporadic cancers; somatic mutation).|T -> N (in sporadic cancers; somatic mutation).|T -> S (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T211T(9)|p.T211I(7)|p.0?(7)|p.T211N(4)|p.T211fs*4(3)|p.R209fs*35(2)|p.T211A(2)|p.T211fs*36(2)|p.T211fs*5(2)|p.D208fs*1(1)|p.T211_F212insX(1)|p.R209_R213delRNTFR(1)|p.D207_R213delDDRNTFR(1)|p.T211fs*28(1)|p.T211_S215delTFRHS(1)|p.K164_P219del(1)|p.D207_V216del10(1)|p.T211P(1)|p.T211S(1)|p.R209fs*6(1)|p.D208_V216delDRNTFRHSV(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGTCGAAAAGTGTTTCTGTC	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578217	A	A	7578217	3	1	188	1	0	0	0	0	1	0	0	0	16378	1029	36	3	662	3	TP53	17	7578217	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08		7578217	73616993	35	13350											
DNAH9	1770	broad.mit.edu	37	chr17	11672470	11672470	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacacgagtgagaccatccGtgtgtgctacttcatggagc	12	11	1	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr17:11672470G>A	uc002gne.2	+	38	7444	c.7376G>A	c.(7375-7377)CGT>CAT	p.R2459H	DNAH9_uc010coo.2_Missense_Mutation_p.R1753H	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2459	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAGACCATCCGTGTGTGCTAC	0.612													A	11672470	A	A	11672470	3	1	188	1	0	0	0	0	1	0	0	0	4608	1145	40	1	7526	1	DNAH9	17	11672470	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	4094253	11672470	69522740	36	13351											
SMCR7	125170	broad.mit.edu	37	chr17	18167560	18167560	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcctgatccggcccagcAtggcctcggaggagctgctg	16	13	0	1			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr17:18167560A>G	uc002gst.2	+	4	1058	c.847A>G	c.(847-849)ATG>GTG	p.M283V	SMCR7_uc002gsu.2_3'UTR|SMCR7_uc010vxq.1_Missense_Mutation_p.M294V	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	283						integral to membrane	protein binding				0	all_neural(463;0.228)					CCGGCCCAGCATGGCCTCGGA	0.667													G	18167560	G	G	18167560	3	3	188	1	0	0	0	0	1	0	0	0	14790	217	8	4	894	4	SMCR7	17	18167560	Missense_Mutation	SNP	A	TCGA-27-1836-01A-01D-1494-08	6495090	18167560	63027650	37	13352											
CCDC144NL	339184	broad.mit.edu	37	chr17	20799291	20799291	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtagactgccggcttcggagAccccccagcccctccccgct	10	20	0	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr17:20799291A>C	uc002gyf.2	-	1	163	c.43T>G	c.(43-45)TCT>GCT	p.S15A	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	15											0						GGCTTCGGAGACCCCCCAGCC	0.647											OREG0024248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	20799291	C	C	20799291	3	2	188	1	0	0	0	0	1	0	0	0	2779	275	10	5	638	5	CCDC144NL	17	20799291	Missense_Mutation	SNP	A	TCGA-27-1836-01A-01D-1494-08	2631731	20799291	60395919	38	13353											
KIF2B	84643	broad.mit.edu	37	chr17	51900492	51900492	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaagagggcatctacgtggCgatccagcgcagtgacaagc	13	12	1	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr17:51900492C>T	uc002iua.2	+	1	254	c.98C>T	c.(97-99)GCG>GTG	p.A33V		NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	33					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						ATCTACGTGGCGATCCAGCGC	0.552													T	51900492	T	T	51900492	3	4	188	1	0	0	0	0	1	0	0	0	8298	768	27	1	100	1	KIF2B	17	51900492	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	31101201	51900492	29294718	39	13354											
ENPP7	339221	broad.mit.edu	37	chr17	77705154	77705154	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacttcaccctggtcaccGgtgagtactgccctgtgacg	11	15	2	2	rs150916536		TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr17:77705154G>A	uc002jxa.2	+	1	273	c.253G>A	c.(253-255)GGC>AGC	p.G85S		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	85					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CCTGGTCACCGGTGAGTACTG	0.647													A	77705154	A	A	77705154	3	1	188	1	0	0	0	0	1	0	0	0	5135	1130	39	2	255	2	ENPP7	17	77705154	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	25804662	77705154	3490056	40	13355											
CELF5	60680	broad.mit.edu	37	chr19	3282231	3282231	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataggcgccgtcagcctcaaCgggctgcctgccacacccat	10	17	2	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr19:3282231C>T	uc002lxm.2	+	7	895	c.858C>T	c.(856-858)AAC>AAT	p.N286N	CELF5_uc002lxl.1_Silent_p.N286N|CELF5_uc010dtj.1_Silent_p.N286N|CELF5_uc010xhg.1_Silent_p.N172N|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	286					mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						TCAGCCTCAACGGGCTGCCTG	0.647													T	3282231	T	T	3282231	2	4	188	1	0	0	0	0	0	0	0	1	3219	535	19	1		1	CELF5	19	3282231	Silent	SNP	C	TCGA-27-1836-01A-01D-1494-08		3282231	55846752	41	13356											
OR7A10	390892	broad.mit.edu	37	chr19	14951969	14951969	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aactgagaggtgagatgcacAggtggaaaatgccttatact	12	6	0	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr19:14951969A>T	uc002mzx.1	-	1	721	c.721T>A	c.(721-723)TGT>AGT	p.C241S		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					TGAGATGCACAGGTGGAAAAT	0.488													T	14951969	T	T	14951969	3	4	188	1	0	0	0	0	1	0	0	0	11214	188	7	5	212	5	OR7A10	19	14951969	Missense_Mutation	SNP	A	TCGA-27-1836-01A-01D-1494-08	11669738	14951969	44177014	42	13357											
ZNF208	7757	broad.mit.edu	37	chr19	22156724	22156724	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctttgccgcattcttcaCatttgtagggtttctctcca	8	11	3	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr19:22156724C>T	uc002nqp.2	-	4	1261	c.1112G>A	c.(1111-1113)TGT>TAT	p.C371Y	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GCATTCTTCACATTTGTAGGG	0.383													T	22156724	T	T	22156724	3	4	188	1	0	0	0	0	1	0	0	0	17763	478	17	3	2734	3	ZNF208	19	22156724	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	7204755	22156724	36972259	43	13358											
KLK6	5653	broad.mit.edu	37	chr19	51466663	51466663	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagagagtttggctgggcGtgccaggcgcaacagcatga	15	9	1	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr19:51466663G>A	uc002pui.2	-	5	600	c.340C>T	c.(340-342)CGC>TGC	p.R114C	KLK6_uc010eoj.2_Intron|KLK6_uc002puh.2_Missense_Mutation_p.R123C|KLK6_uc002puj.2_Missense_Mutation_p.R7C|KLK6_uc010ycn.1_Missense_Mutation_p.R7C|KLK6_uc002pul.2_Missense_Mutation_p.R114C|KLK6_uc002pum.2_Missense_Mutation_p.R7C	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	114	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		TTGGCTGGGCGTGCCAGGCGC	0.612													A	51466663	A	A	51466663	3	1	188	1	0	0	0	0	1	0	0	0	8408	1145	40	1	406	1	KLK6	19	51466663	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	29309939	51466663	7662320	44	13359											
NLRP11	204801	broad.mit.edu	37	chr19	56320357	56320357	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaacaaaggcatatggtgcGtcaacttttccgggtcacgg	11	9	2	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr19:56320357G>A	uc010ygf.1	-	5	2330	c.1619C>T	c.(1618-1620)ACG>ATG	p.T540M	NLRP11_uc002qlz.2_Missense_Mutation_p.T441M|NLRP11_uc002qmb.2_Missense_Mutation_p.T441M|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	540							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CATATGGTGCGTCAACTTTTC	0.448													A	56320357	A	A	56320357	3	1	188	1	0	0	0	0	1	0	0	0	10473	1145	40	1	1514	1	NLRP11	19	56320357	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	4853694	56320357	2808626	45	13360											
DIDO1	11083	broad.mit.edu	37	chr20	61512320	61512320	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcagggcgccgcaaggcGgtgtgggcagcagcaccctc	17	14	0	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr20:61512320G>A	uc002ydr.1	-	16	5252	c.4988C>T	c.(4987-4989)CCG>CTG	p.P1663L	DIDO1_uc002yds.1_Missense_Mutation_p.P1663L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1663					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GCCGCAAGGCGGTGTGGGCAG	0.731													A	61512320	A	A	61512320	3	1	188	1	0	0	0	0	1	0	0	0	4522	1116	39	2	1738	2	DIDO1	20	61512320	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08		61512320	1513200	46	13361											
PLA2G3	50487	broad.mit.edu	37	chr22	31534350	31534350	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgaagaaggccacgcccaCgatgtccgagatggagtcgt	14	10	0	3			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr22:31534350C>T	uc003aka.2	-	3	823	c.694G>A	c.(694-696)GTG>ATG	p.V232M		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	232	Phospholipase A2-like.				cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						GCCACGCCCACGATGTCCGAG	0.617													T	31534350	T	T	31534350	3	4	188	1	0	0	0	0	1	0	0	0	12000	536	19	1	855	1	PLA2G3	22	31534350	Missense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08		31534350	19770216	47	13362											
TTLL12	23170	broad.mit.edu	37	chr22	43575872	43575872	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtccaggtccctcaggggCcacagcagcgtgtaggccac	14	14	1	0			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr22:43575872C>T	uc003bdq.2	-	4	713	c.681G>A	c.(679-681)TGG>TGA	p.W227*	TTLL12_uc003bdr.1_Nonsense_Mutation_p.W227*	NM_015140	NP_055955	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	227					protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)	1		Ovarian(80;0.221)|Glioma(61;0.222)				CCCTCAGGGGCCACAGCAGCG	0.672													T	43575872	T	T	43575872	4	4	188	1	0	0	0	0	0	1	0	0	16722	740	26	3	1297	3	TTLL12	22	43575872	Nonsense_Mutation	SNP	C	TCGA-27-1836-01A-01D-1494-08	12041522	43575872	7728694	48	13363											
CELSR1	9620	broad.mit.edu	37	chr22	46931874	46931874	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctcgttgagctggaagacGtcccacgcgccccccaacac	9	18	1	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chr22:46931874G>A	uc003bhw.1	-	1	1194	c.1194C>T	c.(1192-1194)GAC>GAT	p.D398D		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	398	Extracellular (Potential).|Cadherin 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GCTGGAAGACGTCCCACGCGC	0.682													A	46931874	A	A	46931874	2	1	188	1	0	0	0	0	0	0	0	1	3221	1136	40	1		1	CELSR1	22	46931874	Silent	SNP	G	TCGA-27-1836-01A-01D-1494-08	3356002	46931874	4372692	49	13364											
PPEF1	5475	broad.mit.edu	37	chrX	18797156	18797156	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cccctcagagaggaacccgtAtgtttttaatggtgactttg	10	9	1	2			TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chrX:18797156A>T	uc004cyq.2	+	10	1068	c.587A>T	c.(586-588)TAT>TTT	p.Y196F	PPEF1_uc004cyp.2_Missense_Mutation_p.Y196F|PPEF1_uc004cyr.2_Missense_Mutation_p.Y196F|PPEF1_uc004cys.2_Missense_Mutation_p.Y196F|PPEF1_uc011mja.1_Missense_Mutation_p.Y131F|PPEF1_uc011mjb.1_Missense_Mutation_p.Y140F	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	196	Catalytic.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					AGGAACCCGTATGTTTTTAAT	0.408													T	18797156	T	T	18797156	3	4	188	1	0	0	0	0	1	0	0	0	12307	449	16	5	613	5	PPEF1	23	18797156	Missense_Mutation	SNP	A	TCGA-27-1836-01A-01D-1494-08		18797156	136473404	50	13365											
GPR64	10149	broad.mit.edu	37	chrX	19025360	19025360	+	Frame_Shift_Del	DEL	G	-	-													ggcctctccccacctggctcGggttgatgtgctttaatgtg							TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chrX:19025360delG	uc004cyx.2	-	20	1846	c.1682delC	c.(1681-1683)CCGfs	p.P561fs	GPR64_uc004cyy.2_Frame_Shift_Del_p.P558fs|GPR64_uc004cyz.2_Frame_Shift_Del_p.P547fs|GPR64_uc004czb.2_Frame_Shift_Del_p.P561fs|GPR64_uc004czc.2_Frame_Shift_Del_p.P545fs|GPR64_uc004czd.2_Frame_Shift_Del_p.P537fs|GPR64_uc004cze.2_Frame_Shift_Del_p.P531fs|GPR64_uc004czf.2_Frame_Shift_Del_p.P523fs|GPR64_uc004cza.2_Frame_Shift_Del_p.P539fs|GPR64_uc004cyw.2_Frame_Shift_Del_p.P545fs|GPR64_uc010nfj.2_Intron	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	561	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					CACCTGGCTCGGGTTGATGTG	0.502													-	19025360	-	-	19025360	7	5	188	1	0	1	0	1	0	0	0	0	6705	1116	39	0	1411	0	GPR64	23	19025360	Frame_Shift_Del	DEL	G	TCGA-27-1836-01A-01D-1494-08	228204	19025360	136245200	51	13366											
NXF5	55998	broad.mit.edu	37	chrX	101096651	101096651	+	Frame_Shift_Del	DEL	G	-	-													gccctcagcacacaccttttGgttctcatcatcataaatct							TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chrX:101096651delG	uc011mrk.1	-	5	595	c.235delC	c.(235-237)CAAfs	p.Q79fs	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_Intron|NXF5_uc004eil.1_Intron	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	79	RRM.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						CACACCTTTTGGTTCTCATCA	0.488													-	101096651	-	-	101096651	7	5	188	1	0	1	0	1	0	0	0	0	10786	1357	47	0	910	0	NXF5	23	101096651	Frame_Shift_Del	DEL	G	TCGA-27-1836-01A-01D-1494-08	82071291	101096651	54173909	52	13367											
F8	2157	broad.mit.edu	37	chrX	154159916	154159916	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggcggtcatgcctctgttccGaaagtctgagttgtggcacc	13	11	3	1	rs137852435		TCGA-27-1836-01A-01D-1494-08	TCGA-27-1836-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	8c58f090-31a3-4b2f-93e7-1ae6f6d73350	563efbbc-5c03-4e2c-b085-4cad0e1e43bf	g.chrX:154159916G>A	uc004fmt.2	-	14	2320	c.2149C>T	c.(2149-2151)CGG>TGG	p.R717W		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	717	F5/8 type A 2.|Plastocyanin-like 4.		R -> L (in HEMA; mild).|R -> W (in HEMA; mild).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CCTCTGTTCCGAAAGTCTGAG	0.423													A	154159916	A	A	154159916	3	1	188	1	0	0	0	0	1	0	0	0	5350	1057	37	2	4986	2	F8	23	154159916	Missense_Mutation	SNP	G	TCGA-27-1836-01A-01D-1494-08	53063265	154159916	1110644	53	13368											
CYP4X1	260293	broad.mit.edu	37	chr1	47501571	47501571	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggatataatcatgaaatgcGctttcagcaaggagaccaac	9	8	2	2			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr1:47501571G>A	uc001cqt.2	+	5	836	c.586G>A	c.(586-588)GCT>ACT	p.A196T	CYP4X1_uc001cqr.2_Missense_Mutation_p.A195T|CYP4X1_uc001cqs.2_Missense_Mutation_p.A131T	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	196						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						CATGAAATGCGCTTTCAGCAA	0.428													A	47501571	A	A	47501571	3	1	189	1	0	0	0	0	1	0	0	0	4193	1087	38	1	604	1	CYP4X1	1	47501571	Missense_Mutation	SNP	G	TCGA-27-1837-01A-01D-1494-08		47501571	201749050	1	13369											
SETDB1	9869	broad.mit.edu	37	chr1	150936730	150936730	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcctcttcagaagaatcCgggctgggacagaacttact	9	11	3	3			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr1:150936730C>T	uc001evu.2	+	22	3956	c.3766C>T	c.(3766-3768)CGG>TGG	p.R1256W	SETDB1_uc001evv.2_Missense_Mutation_p.R1255W	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1256	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGAAGAATCCGGGCTGGGAC	0.507													T	150936730	T	T	150936730	3	4	189	1	0	0	0	0	1	0	0	0	14138	643	23	2	3848	2	SETDB1	1	150936730	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	103435159	150936730	98313891	2	13370											
FDPS	2224	broad.mit.edu	37	chr1	155288033	155288033	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctaccgcctgctgaagctctAttgccgggagcagccctatt	10	14	1	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr1:155288033A>G	uc001fkc.2	+	6	854	c.635A>G	c.(634-636)TAT>TGT	p.Y212C	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Missense_Mutation_p.Y146C|FDPS_uc001fke.2_Missense_Mutation_p.Y212C|FDPS_uc001fkf.2_Missense_Mutation_p.Y146C|C1orf104_uc001fkh.1_Intron|RUSC1_uc001fkj.2_5'Flank|RUSC1_uc001fkk.2_5'Flank	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	212					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	CTGAAGCTCTATTGCCGGGAG	0.552													G	155288033	G	G	155288033	3	3	189	1	0	0	0	0	1	0	0	0	5803	449	16	4	653	4	FDPS	1	155288033	Missense_Mutation	SNP	A	TCGA-27-1837-01A-01D-1494-08	4351303	155288033	93962588	3	13371											
TPR	7175	broad.mit.edu	37	chr1	186310460	186310460	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttattggtctccataactAcattcattgtttcagttttc	4	8	3	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr1:186310460A>G	uc001grv.2	-	28	4109	c.3812T>C	c.(3811-3813)GTA>GCA	p.V1271A		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1271	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CTCCATAACTACATTCATTGT	0.343			T	NTRK1	papillary thyroid								G	186310460	G	G	186310460	3	3	189	1	0	0	0	0	1	0	0	0	16413	391	14	4	3375	4	TPR	1	186310460	Missense_Mutation	SNP	A	TCGA-27-1837-01A-01D-1494-08	31022427	186310460	62940161	4	13372											
DPYSL5	56896	broad.mit.edu	37	chr2	27151139	27151139	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccagggtgctaaggaggcacTggatttggggatcacaggcc	16	9	1	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr2:27151139T>C	uc002rhu.3	+	5	775	c.617T>C	c.(616-618)CTG>CCG	p.L206P	DPYSL5_uc002rhv.3_Missense_Mutation_p.L206P	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	206					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGGAGGCACTGGATTTGGGG	0.478													C	27151139	C	C	27151139	3	2	189	1	0	0	0	0	1	0	0	0	4750	1580	55	4	631	4	DPYSL5	2	27151139	Missense_Mutation	SNP	T	TCGA-27-1837-01A-01D-1494-08		27151139	216048234	5	13373											
ALPPL2	251	broad.mit.edu	37	chr2	233274470	233274470	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacaccgcctgcgacctggCgccccgcgccggcaccaccg	11	22	0	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr2:233274470C>T	uc002vss.3	+	11	1540	c.1487C>T	c.(1486-1488)GCG>GTG	p.A496V		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	496					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	TGCGACCTGGCGCCCCGCGCC	0.736													T	233274470	T	T	233274470	3	4	189	1	0	0	0	0	1	0	0	0	549	768	27	1	1529	1	ALPPL2	2	233274470	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	206123331	233274470	9924903	6	13374											
CCDC12	151903	broad.mit.edu	37	chr3	46965117	46965117	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacctcctcgatgacgggctCgggcttggcggcctccagct	13	16	0	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr3:46965117C>T	uc011baq.1	-	4	334	c.325G>A	c.(325-327)GAG>AAG	p.E109K	CCDC12_uc003cqo.2_Missense_Mutation_p.E109K	NM_144716	NP_653317	Q8WUD4	CCD12_HUMAN	coiled-coil domain containing 12	96											0		Prostate(884;0.0143)|Ovarian(412;0.0448)|Acute lymphoblastic leukemia(5;0.143)		OV - Ovarian serous cystadenocarcinoma(275;2.2e-56)|BRCA - Breast invasive adenocarcinoma(193;0.00136)|KIRC - Kidney renal clear cell carcinoma(197;0.00703)|Kidney(197;0.00809)		ATGACGGGCTCGGGCTTGGCG	0.552											OREG0015545	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	46965117	T	T	46965117	3	4	189	1	0	0	0	0	1	0	0	0	2755	893	31	2	230	2	CCDC12	3	46965117	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08		46965117	151057313	7	13375											
OR5H1	26341	broad.mit.edu	37	chr3	97851850	97851850	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaagatacagtttttttcGtttgcaatcagtgtaaccac	7	8	1	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr3:97851850G>A	uc011bgt.1	+	1	309	c.309G>A	c.(307-309)TCG>TCA	p.S103S		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						AGTTTTTTTCGTTTGCAATCA	0.388													A	97851850	A	A	97851850	2	1	189	1	0	0	0	0	0	0	0	1	11159	1132	40	1		1	OR5H1	3	97851850	Silent	SNP	G	TCGA-27-1837-01A-01D-1494-08	50886733	97851850	100170580	8	13376											
SLC9A10	285335	broad.mit.edu	37	chr3	111997653	111997653	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aactactggtgtaaatatacGaaaaaataagtctggactca	7	6	2	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr3:111997653G>A	uc003dyu.2	-	4	463	c.241C>T	c.(241-243)CGT>TGT	p.R81C	SLC9A10_uc011bhu.1_5'UTR|SLC9A10_uc010hqc.2_Missense_Mutation_p.R81C	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	81	Helical; (Potential).				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						GTAAATATACGAAAAAATAAG	0.313													A	111997653	A	A	111997653	3	1	189	1	0	0	0	0	1	0	0	0	14710	1058	37	2	3396	2	SLC9A10	3	111997653	Missense_Mutation	SNP	G	TCGA-27-1837-01A-01D-1494-08	14145803	111997653	86024777	9	13377											
SOX14	8403	broad.mit.edu	37	chr3	137484038	137484038	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cggcctcggcgccctactccCtgctggaccccgcgcagttt	11	19	0	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr3:137484038C>G	uc003erm.1	+	1	460	c.412C>G	c.(412-414)CTG>GTG	p.L138V		NM_004189	NP_004180	O95416	SOX14_HUMAN	SRY-box 14	138					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding				0						GCCCTACTCCCTGCTGGACCC	0.721													G	137484038	G	G	137484038	3	3	189	1	0	0	0	0	1	0	0	0	14945	680	24	5	414	5	SOX14	3	137484038	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	25486385	137484038	60538392	10	13378											
UGT2B28	54490	broad.mit.edu	37	chr4	70148376	70148376	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caaacctgccaaacccctacCtaaggtaaacatactttcgt	4	14	0	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr4:70148376C>A	uc003hej.2	+	2	868	c.866C>A	c.(865-867)CCT>CAT	p.P289H	UGT2B28_uc010ihr.2_Missense_Mutation_p.P289H	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	289					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	AAACCCCTACCTAAGGTAAAC	0.383													A	70148376	A	A	70148376	3	1	189	1	0	0	0	0	1	0	0	0	16957	681	24	5	872	5	UGT2B28	4	70148376	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08		70148376	121005900	11	13379											
ENPEP	2028	broad.mit.edu	37	chr4	111398043	111398043	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggggaccaggtgcaagtccGgaggtgtttcgagtacaaaa	15	7	0	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr4:111398043G>A	uc003iab.3	+	1	815	c.473G>A	c.(472-474)CGG>CAG	p.R158Q		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	158	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GTGCAAGTCCGGAGGTGTTTC	0.627													A	111398043	A	A	111398043	3	1	189	1	0	0	0	0	1	0	0	0	5128	1116	39	2	475	2	ENPEP	4	111398043	Missense_Mutation	SNP	G	TCGA-27-1837-01A-01D-1494-08	41249667	111398043	79756233	12	13380											
PCDHB15	56121	broad.mit.edu	37	chr5	140626805	140626805	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcgagtgctggtgctggaCgccaacgacaactcgccctt	13	13	0	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr5:140626805C>T	uc003lje.2	+	1	1659	c.1659C>T	c.(1657-1659)GAC>GAT	p.D553D		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	553	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGCTGGACGCCAACGACA	0.711													T	140626805	T	T	140626805	2	4	189	1	0	0	0	0	0	0	0	1	11540	535	19	1		1	PCDHB15	5	140626805	Silent	SNP	C	TCGA-27-1837-01A-01D-1494-08		140626805	40288455	13	13381											
PCDHGB2	56103	broad.mit.edu	37	chr5	140740727	140740727	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaaattcttgatgacaacgAttgtgcacctgaagttattg	9	6	1	4	rs150123769	by1000genomes	TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr5:140740727A>C	uc003ljs.1	+	1	1025	c.1025A>C	c.(1024-1026)GAT>GCT	p.D342A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Missense_Mutation_p.D342A	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	342	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGACAACGATTGTGCACCT	0.448													C	140740727	C	C	140740727	3	2	189	1	0	0	0	0	1	0	0	0	11563	333	12	5	1027	5	PCDHGB2	5	140740727	Missense_Mutation	SNP	A	TCGA-27-1837-01A-01D-1494-08	113922	140740727	40174533	14	13382											
PCDHGA11	56105	broad.mit.edu	37	chr5	140802685	140802685	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggcgaggtgcgtacagcgCgggcactgctggacagagac	18	11	0	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr5:140802685C>T	uc003lkq.1	+	1	2149	c.1891C>T	c.(1891-1893)CGG>TGG	p.R631W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.R631W|PCDHGA11_uc003lkp.1_Intron	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	631	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTACAGCGCGGGCACTGCT	0.687													T	140802685	T	T	140802685	3	4	189	1	0	0	0	0	1	0	0	0	11552	759	27	1	1893	1	PCDHGA11	5	140802685	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	61958	140802685	40112575	15	13383											
SGK1	6446	broad.mit.edu	37	chr6	134582969	134582969	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagaagctttataaatatgCattaaaaaattattttttgg	5	3	1	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr6:134582969C>T	uc003qep.2	-	2	985	c.387G>A	c.(385-387)ATG>ATA	p.M129I	SGK1_uc003qeo.3_Intron			O00141	SGK1_HUMAN	SubName: Full=Putative uncharacterized protein DKFZp686H1615;	Error:Variant_position_missing_in_O00141_after_alignment					apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(3)|stomach(1)|lung(1)|central_nervous_system(1)	6	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		TATAAATATGCATTAAAAAAT	0.269													T	134582969	T	T	134582969	3	4	189	1	0	0	0	0	1	0	0	0	14207	725	25	3		3	SGK1	6	134582969	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08		134582969	36532098	16	13384											
ABCA13	154664	broad.mit.edu	37	chr7	48412010	48412010	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acagcggccctttgtaccagCctggtgtacatgatcagctt	10	12	1	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr7:48412010C>A	uc003toq.2	+	33	11074	c.11049C>A	c.(11047-11049)AGC>AGA	p.S3683R	ABCA13_uc010kys.1_Missense_Mutation_p.S757R|ABCA13_uc003tos.1_Missense_Mutation_p.S509R	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3683	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTTGTACCAGCCTGGTGTACA	0.403													A	48412010	A	A	48412010	3	1	189	1	0	0	0	0	1	0	0	0	31	738	26	5	11008	5	ABCA13	7	48412010	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08		48412010	110726653	17	13385											
SEMA3C	10512	broad.mit.edu	37	chr7	80456743	80456743	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttttttttaacacttactgTgggatctttgccagccattt	6	8	1	0	rs13310887		TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr7:80456743T>G	uc003uhj.2	-	4	887	c.325A>C	c.(325-327)ACA>CCA	p.T109P	SEMA3C_uc011kgw.1_Missense_Mutation_p.T127P|SEMA3C_uc011kgx.1_Intron	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	109	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						ACACTTACTGTGGGATCTTTG	0.338													G	80456743	G	G	80456743	3	3	189	1	0	0	0	0	1	0	0	0	14026	1696	59	5	1990	5	SEMA3C	7	80456743	Missense_Mutation	SNP	T	TCGA-27-1837-01A-01D-1494-08	32044733	80456743	78681920	18	13386											
GRM3	2913	broad.mit.edu	37	chr7	86415951	86415951	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcatgcgcagcgacgactcGcgggagctcattgcagccgc	13	14	2	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr7:86415951G>A	uc003uid.2	+	3	1942	c.843G>A	c.(841-843)TCG>TCA	p.S281S	GRM3_uc010lef.2_Silent_p.S279S|GRM3_uc010leg.2_Silent_p.S153S|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	281	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCGACGACTCGCGGGAGCTCA	0.662													A	86415951	A	A	86415951	2	1	189	1	0	0	0	0	0	0	0	1	6798	1074	38	1		1	GRM3	7	86415951	Silent	SNP	G	TCGA-27-1837-01A-01D-1494-08	5959208	86415951	72722712	19	13387											
EMID2	136227	broad.mit.edu	37	chr7	101063350	101063350	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcgtgtaccagagctgccGgtggccggggccctgcgcca	17	15	0	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr7:101063350G>A	uc010lhy.1	+	2	443	c.251G>A	c.(250-252)CGG>CAG	p.R84Q	EMID2_uc003uyo.1_Missense_Mutation_p.R84Q	NM_133457	NP_597714	Q96A83	EMID2_HUMAN	EMI domain containing 2	84	EMI.					collagen				ovary(1)	1	Lung NSC(181;0.215)					CAGAGCTGCCGGTGGCCGGGG	0.647													A	101063350	A	A	101063350	3	1	189	1	0	0	0	0	1	0	0	0	5092	1116	39	2	257	2	EMID2	7	101063350	Missense_Mutation	SNP	G	TCGA-27-1837-01A-01D-1494-08	14647399	101063350	58075313	20	13388											
FBXL13	222235	broad.mit.edu	37	chr7	102604030	102604030	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacaaccacgaaaattcaaaCgcagcacatttaaacgccac	5	13	1	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr7:102604030C>T	uc003vaq.2	-	8	1101	c.674G>A	c.(673-675)CGT>CAT	p.R225H	FBXL13_uc010liq.1_Missense_Mutation_p.R40H|FBXL13_uc010lir.1_Missense_Mutation_p.R225H|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.R225H|FBXL13_uc003vav.2_RNA	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	225											0						AAAATTCAAACGCAGCACATT	0.328													T	102604030	T	T	102604030	3	4	189	1	0	0	0	0	1	0	0	0	5709	536	19	1	1585	1	FBXL13	7	102604030	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	1540680	102604030	56534633	21	13389											
RELN	5649	broad.mit.edu	37	chr7	103368566	103368566	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacatacttaccagttctcGtgggccatatggttcacaga	9	11	2	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr7:103368566G>A	uc003vca.2	-	7	905	c.745C>T	c.(745-747)CGA>TGA	p.R249*	RELN_uc010liz.2_Nonsense_Mutation_p.R249*	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	249					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACCAGTTCTCGTGGGCCATAT	0.408													A	103368566	A	A	103368566	4	1	189	1	0	0	0	0	0	1	0	0	13220	1153	40	1	9873	1	RELN	7	103368566	Nonsense_Mutation	SNP	G	TCGA-27-1837-01A-01D-1494-08	764536	103368566	55770097	22	13390											
CSMD1	64478	broad.mit.edu	37	chr8	3216774	3216774	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatcccaggaagcaggaaaaCgtcagagagtctcccacacc	9	13	2	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr8:3216774C>T	uc011kwk.1	-	21	3597	c.3207G>A	c.(3205-3207)ACG>ACA	p.T1069T	CSMD1_uc011kwj.1_Silent_p.T461T|CSMD1_uc003wqe.2_Silent_p.T225T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1069	Sushi 6.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGCAGGAAAACGTCAGAGAGT	0.552													T	3216774	T	T	3216774	2	4	189	1	0	0	0	0	0	0	0	1	3944	523	19	1		1	CSMD1	8	3216774	Silent	SNP	C	TCGA-27-1837-01A-01D-1494-08		3216774	143147248	23	13391											
TYRP1	7306	broad.mit.edu	37	chr9	12702411	12702414	+	Frame_Shift_Del	DEL	ACAA	-	-													ctcctttttattccaactctAcaaacagtttccgaaacaca							TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr9:12702411_12702414delACAA	uc003zkv.3	+	5	1232_1235	c.1054_1057delACAA	c.(1054-1059)ACAAACfs	p.T352fs		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	352_353	Lumenal, melanosome (Potential).				melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		TTCCAACTCTACAAACAGTTTCCG	0.387									Oculocutaneous_Albinism				-	12702414	-	-	12702411	7	5	189	1	0	1	0	1	0	0	0	0	16813	391	14	0	1068	0	TYRP1	9	12702411	Frame_Shift_Del	DEL	ACAA	TCGA-27-1837-01A-01D-1494-08		12702411	128511020	24	13392											
C9orf80	58493	broad.mit.edu	37	chr9	115451883	115451883	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agtccttattaagagagggtCtcgagagtgcaatgctaaaa	11	6	1	2			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr9:115451883C>A	uc004bgg.2	-	4	320	c.143G>T	c.(142-144)AGA>ATA	p.R48I	C9orf80_uc010muk.2_Intron	NM_021218	NP_067041	Q9NRY2	SOSSC_HUMAN	SOSSC protein	48					DNA repair|response to ionizing radiation	SOSS complex	protein binding				0						AAGAGAGGGTCTCGAGAGTGC	0.428													A	115451883	A	A	115451883	3	1	189	1	0	0	0	0	1	0	0	0	2498	913	32	5	179	5	C9orf80	9	115451883	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	102749472	115451883	25761548	25	13393											
MYO3A	53904	broad.mit.edu	37	chr10	26482157	26482157	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctgtaaaggagaggagccaAaaatattgagacccccaaga	10	8	1	3	rs34204285	by1000genomes	TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr10:26482157A>G	uc001isn.2	+	32	4822	c.4462A>G	c.(4462-4464)AAA>GAA	p.K1488E	MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1488					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AGAGGAGCCAAAAATATTGAG	0.358													G	26482157	G	G	26482157	3	3	189	1	0	0	0	0	1	0	0	0	10076	15	1	4	4580	4	MYO3A	10	26482157	Missense_Mutation	SNP	A	TCGA-27-1837-01A-01D-1494-08		26482157	109052590	26	13394											
PTEN	5728	broad.mit.edu	37	chr10	89720679	89720679	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttcacttttgggtaaataCattcttcataccaggaccag	7	9	3	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr10:89720679C>T	uc001kfb.2	+	9	1861	c.830C>T	c.(829-831)ACA>ATA	p.T277I		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	277	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.D268_F279>VGQNVSLLGKYI(2)|p.G165_*404del(1)|p.G165_K342del(1)|p.T277I(1)|p.W274_F341del(1)|p.T277fs*13(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGGGTAAATACATTCTTCATA	0.259		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89720679	T	T	89720679	3	4	189	1	0	0	0	0	1	0	0	0	12738	478	17	3	860	3	PTEN	10	89720679	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	63238522	89720679	45814068	27	13395											
MUC5B	727897	broad.mit.edu	37	chr11	1155150	1155150	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgtctccgcaggggtccCgctccgtggggcgactgtct	14	16	2	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr11:1155150C>T	uc009ycr.1	+	4	284	c.158C>T	c.(157-159)CCG>CTG	p.P53L		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	58					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCAGGGGTCCCGCTCCGTGGG	0.667													T	1155150	T	T	1155150	3	4	189	1	0	0	0	0	1	0	0	0	9979	667	23	2		2	MUC5B	11	1155150	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08		1155150	133851366	28	13396											
OR4D5	219875	broad.mit.edu	37	chr11	123811011	123811011	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatgctccgaagccactcaCgggagggccgcagcaaggcc	13	15	2	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr11:123811011C>T	uc001pzk.1	+	1	688	c.688C>T	c.(688-690)CGG>TGG	p.R230W		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AAGCCACTCACGGGAGGGCCG	0.522													T	123811011	T	T	123811011	3	4	189	1	0	0	0	0	1	0	0	0	11057	527	19	1	690	1	OR4D5	11	123811011	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	122655861	123811011	11195505	29	13397											
ADAMTS15	170689	broad.mit.edu	37	chr11	130343595	130343595	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgctccaagagctgcggccGgggatttcagaggcgctcac	14	13	2	2			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr11:130343595G>A	uc010scd.1	+	8	2732	c.2732G>A	c.(2731-2733)CGG>CAG	p.R911Q		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	911	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		AGCTGCGGCCGGGGATTTCAG	0.682													A	130343595	A	A	130343595	3	1	189	1	0	0	0	0	1	0	0	0	260	1116	39	2	2762	2	ADAMTS15	11	130343595	Missense_Mutation	SNP	G	TCGA-27-1837-01A-01D-1494-08	6532584	130343595	4662921	30	13398											
CLSTN3	9746	broad.mit.edu	37	chr12	7302219	7302219	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccgagcgggaaagcctgctCctggacacaacctctctgca	10	16	1	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr12:7302219C>T	uc001qsr.2	+	14	2453	c.2175C>T	c.(2173-2175)CTC>CTT	p.L725L	CLSTN3_uc001qss.2_Silent_p.L737L	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	725	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						AAAGCCTGCTCCTGGACACAA	0.582													T	7302219	T	T	7302219	2	4	189	1	0	0	0	0	0	0	0	1	3563	842	30	3		3	CLSTN3	12	7302219	Silent	SNP	C	TCGA-27-1837-01A-01D-1494-08		7302219	126549676	31	13399											
ACSM4	341392	broad.mit.edu	37	chr12	7477186	7477186	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagtagtccagatcaaatcCgcggagaggtagatgaatgt	12	7	2	4			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr12:7477186C>T	uc001qsx.1	+	11	1528	c.1528C>T	c.(1528-1530)CGC>TGC	p.R510C		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	510					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						AGATCAAATCCGCGGAGAGGT	0.438													T	7477186	T	T	7477186	3	4	189	1	0	0	0	0	1	0	0	0	186	652	23	2	1570	2	ACSM4	12	7477186	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	174967	7477186	126374709	32	13400											
TUBA1A	7846	broad.mit.edu	37	chr12	49578914	49578914	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaactcaccttcctccatcCcctccccaacgtaccagtga	3	19	1	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr12:49578914C>T	uc009zlf.2	-	4	1507	c.1235G>A	c.(1234-1236)GGG>GAG	p.G412E	TUBA1B_uc001rto.2_Intron|TUBA1A_uc001rtp.2_Missense_Mutation_p.G412E|TUBA1A_uc001rtq.2_Missense_Mutation_p.G259E|TUBA1A_uc001rtr.2_Missense_Mutation_p.G259E|TUBA1A_uc009zlg.2_Missense_Mutation_p.G259E	NM_006009	NP_006000	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	412					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity				0						TTCCTCCATCCCCTCCCCAAC	0.547													T	49578914	T	T	49578914	3	4	189	1	0	0	0	0	1	0	0	0	16740	623	22	3	124	3	TUBA1A	12	49578914	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	42101728	49578914	84272981	33	13401											
GLTP	51228	broad.mit.edu	37	chr12	110290512	110290512	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggagagcgctttcaggaagtCagacttatagggtgctgcgt	15	7	2	2			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr12:110290512C>T	uc001tpm.2	-	5	592	c.478G>A	c.(478-480)GAC>AAC	p.D160N	GLTP_uc010sxt.1_RNA	NM_016433	NP_057517	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	160						cytoplasm	glycolipid binding|glycolipid transporter activity				0		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)		TTCAGGAAGTCAGACTTATAG	0.587											OREG0022112	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	110290512	T	T	110290512	3	4	189	1	0	0	0	0	1	0	0	0	6471	826	29	3	155	3	GLTP	12	110290512	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	60711598	110290512	23561383	34	13402											
IQCH	64799	broad.mit.edu	37	chr15	67664811	67664811	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagatggaaattcggaggcCgccatgaagatccaagccac	11	11	0	3	rs111681102	byFrequency	TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr15:67664811C>T	uc002aqo.1	+	9	1163	c.1116C>T	c.(1114-1116)GCC>GCT	p.A372A	IQCH_uc010ujv.1_Silent_p.A191A|IQCH_uc002aqn.1_Silent_p.A199A|IQCH_uc002aqq.1_Silent_p.A120A|IQCH_uc002aqp.1_Silent_p.A124A	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	372	IQ.									skin(3)|ovary(1)	4				Colorectal(3;0.0856)		ATTCGGAGGCCGCCATGAAGA	0.468													T	67664811	T	T	67664811	2	4	189	1	0	0	0	0	0	0	0	1	7811	639	23	2		2	IQCH	15	67664811	Silent	SNP	C	TCGA-27-1837-01A-01D-1494-08		67664811	34866581	35	13403											
ZKSCAN2	342357	broad.mit.edu	37	chr16	25251329	25251329	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccagtgtgtattctccgatgTtctcgaaatctcgtacagtt	8	10	3	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr16:25251329T>C	uc002dod.3	-	7	3119	c.2712A>G	c.(2710-2712)GAA>GAG	p.E904E	ZKSCAN2_uc010vcl.1_Silent_p.E700E	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	904	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		TTCTCCGATGTTCTCGAAATC	0.458													C	25251329	C	C	25251329	2	2	189	1	0	0	0	0	0	0	0	1	17684	1722	60	4		4	ZKSCAN2	16	25251329	Silent	SNP	T	TCGA-27-1837-01A-01D-1494-08		25251329	65103424	36	13404											
ZNF48	197407	broad.mit.edu	37	chr16	30409511	30409511	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgtggaaaggagtttgccCggggatccgacctggtgaag	17	7	0	1	rs141362652		TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr16:30409511C>T	uc002dya.1	+	2	999	c.940C>T	c.(940-942)CGG>TGG	p.R314W	ZNF48_uc002dxz.1_Missense_Mutation_p.R191W	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	314	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAGTTTGCCCGGGGATCCGA	0.622													T	30409511	T	T	30409511	3	4	189	1	0	0	0	0	1	0	0	0	17931	643	23	2	946	2	ZNF48	16	30409511	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	5158182	30409511	59945242	37	13405											
WDR81	124997	broad.mit.edu	37	chr17	1634533	1634533	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgctgcccgtgctcagcttcCtcacctccctcgtcacgggg	10	18	3	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr17:1634533C>G	uc002fti.2	+	4	718	c.457C>G	c.(457-459)CTC>GTC	p.L153V	WDR81_uc002fth.2_Missense_Mutation_p.L329V|WDR81_uc010vqp.1_Missense_Mutation_p.L177V|WDR81_uc002ftj.2_Missense_Mutation_p.L1380V|WDR81_uc010vqq.1_Intron	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	153										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GCTCAGCTTCCTCACCTCCCT	0.498													G	1634533	G	G	1634533	3	3	189	1	0	0	0	0	1	0	0	0	17327	681	24	5	4214	5	WDR81	17	1634533	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08		1634533	79560677	38	13406											
NCOR1	9611	broad.mit.edu	37	chr17	16062148	16062148	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aggaggggacacgggcttctCaggctcaggaggtttagctg	17	8	2	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr17:16062148C>T	uc002gpo.2	-	6	898	c.658G>A	c.(658-660)GAG>AAG	p.E220K	NCOR1_uc002gpn.2_Missense_Mutation_p.E220K|NCOR1_uc002gpp.1_Missense_Mutation_p.E111K|NCOR1_uc002gpr.2_Missense_Mutation_p.E111K|NCOR1_uc002gps.1_Missense_Mutation_p.E220K|NCOR1_uc010coz.1_Missense_Mutation_p.E36K|NCOR1_uc010cpb.1_Missense_Mutation_p.E220K|NCOR1_uc010cpa.1_Missense_Mutation_p.E220K	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	220	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ACGGGCTTCTCAGGCTCAGGA	0.488													T	16062148	T	T	16062148	3	4	189	1	0	0	0	0	1	0	0	0	10235	835	29	3	6828	3	NCOR1	17	16062148	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	14427615	16062148	65133062	39	13407											
SLC4A1	6521	broad.mit.edu	37	chr17	42335476	42335476	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtaataggggtagcggcgcCggatatcacgcaccaggccc	15	12	1	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr17:42335476C>T	uc002igf.3	-	11	1309	c.1160G>A	c.(1159-1161)CGG>CAG	p.R387Q	SLC4A1_uc002igg.3_Missense_Mutation_p.R387Q	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	387	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GTAGCGGCGCCGGATATCACG	0.587													T	42335476	T	T	42335476	3	4	189	1	0	0	0	0	1	0	0	0	14650	652	23	2	1615	2	SLC4A1	17	42335476	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08	26273328	42335476	38859734	40	13408											
ABCA5	23461	broad.mit.edu	37	chr17	67290837	67290837	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacccttctttctgtatgtcTtctgaataccactaattctg	4	12	5	1			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr17:67290837T>G	uc002jif.2	-	10	2672	c.1454A>C	c.(1453-1455)AAG>ACG	p.K485T	ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.K485T|ABCA5_uc002jih.2_Missense_Mutation_p.K485T|ABCA5_uc010dfe.2_Missense_Mutation_p.K485T	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	485	ABC transporter 1.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					TCTGTATGTCTTCTGAATACC	0.264													G	67290837	G	G	67290837	3	3	189	1	0	0	0	0	1	0	0	0	35	1609	56	5	3590	5	ABCA5	17	67290837	Missense_Mutation	SNP	T	TCGA-27-1837-01A-01D-1494-08	24955361	67290837	13904373	41	13409											
CLDN14	23562	broad.mit.edu	37	chr21	37833394	37833394	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtttgcagtggtcgtggtGgccctgggcggggcctggta	20	8	0	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr21:37833394G>A	uc002yvk.1	-	2	742	c.600C>T	c.(598-600)GCC>GCT	p.A200A	CLDN14_uc002yvn.1_Silent_p.A200A|CLDN14_uc002yvo.1_Silent_p.A200A|CLDN14_uc002yvl.1_Silent_p.A200A|CLDN14_uc002yvm.1_Silent_p.A200A	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	200	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TGGTCGTGGTGGCCCTGGGCG	0.652													A	37833394	A	A	37833394	2	1	189	1	0	0	0	0	0	0	0	1	3475	1335	47	3		3	CLDN14	21	37833394	Silent	SNP	G	TCGA-27-1837-01A-01D-1494-08		37833394	10296501	42	13410											
RFPL1	5988	broad.mit.edu	37	chr22	29834818	29834818	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgtcacaactaacaggctttCacctcacggaaattttcttc	5	12	4	0			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chr22:29834818C>T	uc003afn.2	+	1	247	c.38C>T	c.(37-39)TCA>TTA	p.S13L	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	13							zinc ion binding				0						AACAGGCTTTCACCTCACGGA	0.463													T	29834818	T	T	29834818	3	4	189	1	0	0	0	0	1	0	0	0	13253	838	29	3	40	3	RFPL1	22	29834818	Missense_Mutation	SNP	C	TCGA-27-1837-01A-01D-1494-08		29834818	21469748	43	13411											
SPIN2B	474343	broad.mit.edu	37	chrX	57146697	57146697	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attatggtatttgcaaggttGgcatcactaatgtgagatga	11	4	1	2			TCGA-27-1837-01A-01D-1494-08	TCGA-27-1837-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	61ad1d55-21a9-49c4-925b-54a24703afda	2105c6c4-df9f-4762-b894-7fc96cbe7559	g.chrX:57146697G>A	uc004duy.2	-	2	625	c.366C>T	c.(364-366)GCC>GCT	p.A122A	SPIN2B_uc004duz.2_Silent_p.A122A|SPIN2B_uc004dva.2_Silent_p.A122A|uc011mor.1_RNA	NM_001006682	NP_001006683	Q9BPZ2	SPI2B_HUMAN	spindlin-like protein 2	122					apoptosis|cell cycle|gamete generation	nucleus					0						TTGCAAGGTTGGCATCACTAA	0.433													A	57146697	A	A	57146697	2	1	189	1	0	0	0	0	0	0	0	1	15053	1335	47	3		3	SPIN2B	23	57146697	Silent	SNP	G	TCGA-27-1837-01A-01D-1494-08		57146697	98123863	44	13412											
EPHA8	2046	broad.mit.edu	37	chr1	22927229	22927229	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctcctcggccagcgacgtgTggagcttcggcgtggtcatg	15	12	2	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr1:22927229T>C	uc001bfx.1	+	14	2589	c.2464T>C	c.(2464-2466)TGG>CGG	p.W822R		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	822	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CAGCGACGTGTGGAGCTTCGG	0.657													C	22927229	C	C	22927229	3	2	190	1	0	0	0	0	1	0	0	0	5173	1696	59	4	2691	4	EPHA8	1	22927229	Missense_Mutation	SNP	T	TCGA-27-1838-01A-01D-1494-08		22927229	226323392	1	13413											
ABCD3	5825	broad.mit.edu	37	chr1	94965170	94965170	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagaaaagcaaagaatggcGgtaagtatactgtgaagaag	14	3	0	4			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr1:94965170G>A	uc001dqn.3	+	20	1842	c.1740G>A	c.(1738-1740)GCG>GCA	p.A580A	ABCD3_uc010oto.1_Silent_p.A604A|ABCD3_uc010otp.1_Silent_p.A507A|ABCD3_uc009wdr.2_Silent_p.A470A|ABCD3_uc001dqo.3_Silent_p.A268A	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	580	ABC transporter.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		AAAGAATGGCGGTAAGTATAC	0.418													A	94965170	A	A	94965170	2	1	190	1	0	0	0	0	0	0	0	1	62	1130	39	2		2	ABCD3	1	94965170	Silent	SNP	G	TCGA-27-1838-01A-01D-1494-08	72037941	94965170	154285451	2	13414											
FCRL5	83416	broad.mit.edu	37	chr1	157490328	157490328	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaagggccacttctgttcGcggtcagccctgagggggag	15	11	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr1:157490328G>A	uc001fqu.2	-	12	2683	c.2525C>T	c.(2524-2526)GCG>GTG	p.A842V	FCRL5_uc009wsm.2_Missense_Mutation_p.A842V	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	842	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				ACTTCTGTTCGCGGTCAGCCC	0.657													A	157490328	A	A	157490328	3	1	190	1	0	0	0	0	1	0	0	0	5798	1087	38	1	432	1	FCRL5	1	157490328	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	62525158	157490328	91760293	3	13415											
SPTA1	6708	broad.mit.edu	37	chr1	158615013	158615013	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggtctaggatcttcttgcGtttttcccaagccttctcca	7	13	4	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr1:158615013G>A	uc001fst.1	-	29	4358	c.4159C>T	c.(4159-4161)CGC>TGC	p.R1387C		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1387	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ATCTTCTTGCGTTTTTCCCAA	0.433													A	158615013	A	A	158615013	3	1	190	1	0	0	0	0	1	0	0	0	15115	1145	40	1	3196	1	SPTA1	1	158615013	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	1124685	158615013	90635608	4	13416											
CFHR4	10877	broad.mit.edu	37	chr1	196887346	196887346	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttttctgctttcagatccatGtataataactgaagaaaaca	5	7	2	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr1:196887346G>T	uc001gto.2	+	6	875	c.806G>T	c.(805-807)TGT>TTT	p.C269F	CFHR4_uc009wyy.2_Missense_Mutation_p.C515F|CFHR4_uc001gtp.2_Missense_Mutation_p.C516F	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	269	Sushi 5.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TCAGATCCATGTATAATAACT	0.264													T	196887346	T	T	196887346	3	4	190	1	0	0	0	0	1	0	0	0	3287	1377	48	5	828	5	CFHR4	1	196887346	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	38272333	196887346	52363275	5	13417											
OR2AK2	391191	broad.mit.edu	37	chr1	248129572	248129572	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgagaaataaggaagtgacGggggcagtgaggagactgtt	17	4	0	4			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr1:248129572G>A	uc010pzd.1	+	1	939	c.939G>A	c.(937-939)ACG>ACA	p.T313T	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			AGGAAGTGACGGGGGCAGTGA	0.433													A	248129572	A	A	248129572	2	1	190	1	0	0	0	0	0	0	0	1	10986	1103	39	2		2	OR2AK2	1	248129572	Silent	SNP	G	TCGA-27-1838-01A-01D-1494-08	51242226	248129572	1121049	6	13418											
ALLC	55821	broad.mit.edu	37	chr2	3727515	3727515	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtcatccggggcttcgacGtggacgtttcttacttcacg	12	11	3	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr2:3727515G>A	uc010ewt.2	+	5	390	c.229G>A	c.(229-231)GTG>ATG	p.V77M		NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	96							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		GGGCTTCGACGTGGACGTTTC	0.547										HNSCC(21;0.051)			A	3727515	A	A	3727515	3	1	190	1	0	0	0	0	1	0	0	0	534	1145	40	1	243	1	ALLC	2	3727515	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08		3727515	239471858	7	13419											
RAD51AP2	729475	broad.mit.edu	37	chr2	17696534	17696534	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cattattgggtacagttttcCatttaaataaactttggtga	7	5	0	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr2:17696534C>A	uc002rcl.1	-	1	3173	c.3149G>T	c.(3148-3150)TGG>TTG	p.W1050L	RAD51AP2_uc010exn.1_Missense_Mutation_p.W1041L	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	1050										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TACAGTTTTCCATTTAAATAA	0.368													A	17696534	A	A	17696534	3	1	190	1	0	0	0	0	1	0	0	0	12987	595	21	5	342	5	RAD51AP2	2	17696534	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	13969019	17696534	225502839	8	13420											
MSH6	2956	broad.mit.edu	37	chr2	48026087	48026087	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggaaggaaacgccctcagCcaccaaacaagcaactagca	8	13	1	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr2:48026087C>T	uc002rwd.3	+	4	1117	c.965C>T	c.(964-966)GCC>GTC	p.A322V	MSH6_uc002rwc.2_Missense_Mutation_p.A322V|MSH6_uc010fbj.2_Missense_Mutation_p.A20V|MSH6_uc010yoi.1_Missense_Mutation_p.A192V|MSH6_uc010yoj.1_Missense_Mutation_p.A20V	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	322					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACGCCCTCAGCCACCAAACAA	0.473			Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				T	48026087	T	T	48026087	3	4	190	1	0	0	0	0	1	0	0	0	9874	739	26	3	979	3	MSH6	2	48026087	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	30329553	48026087	195173286	9	13421											
TSGA10	80705	broad.mit.edu	37	chr2	99634812	99634812	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttcttgtacggccctctcCctaaagcaaaatagtgatgc	8	11	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr2:99634812C>T	uc002szg.3	-	18	2551	c.1923G>A	c.(1921-1923)AGG>AGA	p.R641R	TSGA10_uc002szh.3_Silent_p.R641R|TSGA10_uc002szi.3_Silent_p.R641R|TSGA10_uc010fin.1_Silent_p.R641R	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	641	Interaction with HIF1A (By similarity).				spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						CGGCCCTCTCCCTAAAGCAAA	0.323													T	99634812	T	T	99634812	2	4	190	1	0	0	0	0	0	0	0	1	16614	637	22	3		3	TSGA10	2	99634812	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08	51608725	99634812	143564561	10	13422											
IL1R1	3554	broad.mit.edu	37	chr2	102789175	102789175	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atcctgcaaacaaaagaaggAgtaccctcatcacagtgctt	7	11	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr2:102789175A>T	uc002tbq.2	+	9	1186	c.868A>T	c.(868-870)AGT>TGT	p.S290C	IL1R1_uc010fix.2_Missense_Mutation_p.S290C|IL1R1_uc002tbp.2_Missense_Mutation_p.S290C|IL1R1_uc002tbr.2_Missense_Mutation_p.S290C	NM_000877	NP_000868	P14778	IL1R1_HUMAN	interleukin 1 receptor, type I precursor	290	Ig-like C2-type 3.|Extracellular (Potential).				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			skin(1)	1					Anakinra(DB00026)	CAAAAGAAGGAGTACCCTCAT	0.348													T	102789175	T	T	102789175	3	4	190	1	0	0	0	0	1	0	0	0	7658	304	11	5	894	5	IL1R1	2	102789175	Missense_Mutation	SNP	A	TCGA-27-1838-01A-01D-1494-08	3154363	102789175	140410198	11	13423											
SLC9A4	389015	broad.mit.edu	37	chr2	103141556	103141556	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaagagattctgatccgccGccagaacaccttaagggaga	10	10	1	4			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr2:103141556G>A	uc002tbz.3	+	10	2349	c.1892G>A	c.(1891-1893)CGC>CAC	p.R631H		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	631	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CTGATCCGCCGCCAGAACACC	0.507													A	103141556	A	A	103141556	3	1	190	1	0	0	0	0	1	0	0	0	14716	1087	38	1	1930	1	SLC9A4	2	103141556	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	352381	103141556	140057817	12	13424											
XIRP2	129446	broad.mit.edu	37	chr2	168103543	168103543	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacttaaagaatcaagccatCgatggaaagaatctaaacag	7	8	2	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr2:168103543C>T	uc002udx.2	+	8	5659	c.5641C>T	c.(5641-5643)CGA>TGA	p.R1881*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.R1706*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.R1659*|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1706					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATCAAGCCATCGATGGAAAGA	0.378													T	168103543	T	T	168103543	4	4	190	1	0	0	0	0	0	1	0	0	17427	876	31	2	5671	2	XIRP2	2	168103543	Nonsense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	64961987	168103543	75095830	13	13425											
TTN	7273	broad.mit.edu	37	chr2	179431526	179431526	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taatcctgtcactcttagacGcaaatctgtaatgcggcgtt	8	10	3	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr2:179431526G>A	uc010zfg.1	-	275	71853	c.71629C>T	c.(71629-71631)CGT>TGT	p.R23877C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R17572C|TTN_uc010zfi.1_Missense_Mutation_p.R17505C|TTN_uc010zfj.1_Missense_Mutation_p.R17380C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24804							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCTTAGACGCAAATCTGTA	0.408													A	179431526	A	A	179431526	3	1	190	1	0	0	0	0	1	0	0	0	16732	1087	38	1	28794	1	TTN	2	179431526	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	11327983	179431526	63767847	14	13426											
TRIM71	131405	broad.mit.edu	37	chr3	32932739	32932739	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcgcatccagatcttcacGttcgagggccagttcctcct	8	15	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr3:32932739G>A	uc003cff.2	+	4	2106	c.2043G>A	c.(2041-2043)ACG>ACA	p.T681T		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	681	NHL 2.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						AGATCTTCACGTTCGAGGGCC	0.582													A	32932739	A	A	32932739	2	1	190	1	0	0	0	0	0	0	0	1	16541	1132	40	1		1	TRIM71	3	32932739	Silent	SNP	G	TCGA-27-1838-01A-01D-1494-08		32932739	165089691	15	13427											
AMIGO3	386724	broad.mit.edu	37	chr3	49756785	49756785	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcaggtcggcagcgcagatAcatttgtaggggcagttgtg	16	7	0	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr3:49756785A>G	uc003cxj.2	-	1	454	c.114T>C	c.(112-114)TGT>TGC	p.C38C	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	38	Extracellular (Potential).|LRRNT.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CAGCGCAGATACATTTGTAGG	0.647											OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	49756785	G	G	49756785	2	3	190	1	0	0	0	0	0	0	0	1	577	389	14	4		4	AMIGO3	3	49756785	Silent	SNP	A	TCGA-27-1838-01A-01D-1494-08	16824046	49756785	148265645	16	13428											
HTR1F	3355	broad.mit.edu	37	chr3	88040099	88040099	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttaatttgttcccttgcagTcacagattttcttgtggctg	8	8	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr3:88040099T>A	uc003dqr.2	+	2	358	c.200T>A	c.(199-201)GTC>GAC	p.V67D		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	67	Helical; Name=2; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	TCCCTTGCAGTCACAGATTTT	0.463													A	88040099	A	A	88040099	3	1	190	1	0	0	0	0	1	0	0	0	7440	1667	58	5	202	5	HTR1F	3	88040099	Missense_Mutation	SNP	T	TCGA-27-1838-01A-01D-1494-08	38283314	88040099	109982331	17	13429											
FAM55C	91775	broad.mit.edu	37	chr3	101520152	101520152	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtttcctcccaggtgacagGaattagccgaaatccctact	8	12	0	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr3:101520152G>A	uc003dvn.2	+	5	804	c.167G>A	c.(166-168)GGA>GAA	p.G56E	FAM55C_uc010hpn.2_Missense_Mutation_p.G56E	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	56						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						CAGGTGACAGGAATTAGCCGA	0.522													A	101520152	A	A	101520152	3	1	190	1	0	0	0	0	1	0	0	0	5586	1174	41	3	173	3	FAM55C	3	101520152	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	13480053	101520152	96502278	18	13430											
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178936091	A	A	178936091	3	1	190	1	0	0	0	0	1	0	0	0	11913	1291	45	3	1667	3	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	77415939	178936091	19086339	19	13431											
GABRB1	2560	broad.mit.edu	37	chr4	47322182	47322182	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atgtatgatggatcttcgaaGatatccattggatgagcaga	11	5	1	4			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr4:47322182G>T	uc003gxh.2	+	5	874	c.500G>T	c.(499-501)AGA>ATA	p.R167I	GABRB1_uc011bze.1_Missense_Mutation_p.R97I	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	167	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GATCTTCGAAGATATCCATTG	0.418													T	47322182	T	T	47322182	3	4	190	1	0	0	0	0	1	0	0	0	6166	942	33	5	518	5	GABRB1	4	47322182	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08		47322182	143832094	20	13432											
HPSE	10855	broad.mit.edu	37	chr4	84216623	84216623	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggcaaggtttgatcatccacCatctttagagttagaccatt	8	9	2	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr4:84216623C>G	uc003hoj.3	-	12	1605	c.1506G>C	c.(1504-1506)ATG>ATC	p.M502I	uc003hoi.2_5'Flank|HPSE_uc010ika.2_Missense_Mutation_p.M444I|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.M245I|HPSE_uc011cct.1_Missense_Mutation_p.M428I|HPSE_uc003hok.3_Missense_Mutation_p.M502I	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	502					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	GATCATCCACCATCTTTAGAG	0.443													G	84216623	G	G	84216623	3	3	190	1	0	0	0	0	1	0	0	0	7344	594	21	5	129	5	HPSE	4	84216623	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	36894441	84216623	106937653	21	13433											
LRIT3	345193	broad.mit.edu	37	chr4	110791269	110791269	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaaaagaaatttaaaggtggCaaagaatggaagtaagcttc	11	3	0	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr4:110791269C>A	uc003hzx.3	+	3	1422	c.1229C>A	c.(1228-1230)GCA>GAA	p.A410E	LRIT3_uc003hzw.3_Missense_Mutation_p.A272E	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	410						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TTAAAGGTGGCAAAGAATGGA	0.453													A	110791269	A	A	110791269	3	1	190	1	0	0	0	0	1	0	0	0	8949	710	25	5	1239	5	LRIT3	4	110791269	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	26574646	110791269	80363007	22	13434											
MYOZ2	51778	broad.mit.edu	37	chr4	120072132	120072132	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccaggctatttaagatgcGtcaaagaagatctgacaaat	9	7	2	4			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr4:120072132G>A	uc003icp.3	+	3	395	c.182G>A	c.(181-183)CGT>CAT	p.R61H		NM_016599	NP_057683	Q9NPC6	MYOZ2_HUMAN	myozenin 2	61							protein phosphatase 2B binding				0						TTTAAGATGCGTCAAAGAAGA	0.398													A	120072132	A	A	120072132	3	1	190	1	0	0	0	0	1	0	0	0	10096	1145	40	1	188	1	MYOZ2	4	120072132	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	9280863	120072132	71082144	23	13435											
FSTL5	56884	broad.mit.edu	37	chr4	162577565	162577565	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcagggttccttgaatggcaCagctcagaacagcactttgt	10	10	2	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr4:162577565C>G	uc003iqh.2	-	7	1245	c.809G>C	c.(808-810)TGT>TCT	p.C270S	FSTL5_uc003iqi.2_Missense_Mutation_p.C269S|FSTL5_uc010iqv.2_Missense_Mutation_p.C269S	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	270	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTGAATGGCACAGCTCAGAAC	0.393													G	162577565	G	G	162577565	3	3	190	1	0	0	0	0	1	0	0	0	6080	478	17	5	1774	5	FSTL5	4	162577565	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	42505433	162577565	28576711	24	13436											
OSMR	9180	broad.mit.edu	37	chr5	38904563	38904563	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atgccagccacttctggaaaTggagtgaatggagtggtcag	14	7	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr5:38904563T>A	uc003jln.1	+	9	1610	c.1243T>A	c.(1243-1245)TGG>AGG	p.W415R		NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	415	WSXWS motif.|Fibronectin type-III 1.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					CTTCTGGAAATGGAGTGAATG	0.488													A	38904563	A	A	38904563	3	1	190	1	0	0	0	0	1	0	0	0	11292	1464	51	5	1311	5	OSMR	5	38904563	Missense_Mutation	SNP	T	TCGA-27-1838-01A-01D-1494-08		38904563	142010697	25	13437											
COX7C	1350	broad.mit.edu	37	chr5	85915176	85915176	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttttttccaacagaatttgCcattttcagtggaaaacaag	6	7	1	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr5:85915176C>T	uc003kir.2	+	2	171	c.82C>T	c.(82-84)CCA>TCA	p.P28S		NM_001867	NP_001858	P15954	COX7C_HUMAN	cytochrome c oxidase subunit VIIc precursor	28	Mitochondrial matrix (By similarity).				respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	cytochrome-c oxidase activity				0		all_cancers(142;7e-06)|Lung NSC(167;0.000601)|all_lung(232;0.000693)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;1.56e-40)|Epithelial(54;3.17e-34)|all cancers(79;3.36e-29)		ACAGAATTTGCCATTTTCAGT	0.338													T	85915176	T	T	85915176	3	4	190	1	0	0	0	0	1	0	0	0	3784	739	26	3	88	3	COX7C	5	85915176	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	47010613	85915176	95000084	26	13438											
PCDHA12	56137	broad.mit.edu	37	chr5	140255258	140255258	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcgcctgttccgggtggcGtccaaaagacacggggacct	14	14	0	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr5:140255258G>A	uc003lic.2	+	1	328	c.201G>A	c.(199-201)GCG>GCA	p.A67A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.A67A	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	67	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCGGGTGGCGTCCAAAAGAC	0.632													A	140255258	A	A	140255258	2	1	190	1	0	0	0	0	0	0	0	1	11522	1132	40	1		1	PCDHA12	5	140255258	Silent	SNP	G	TCGA-27-1838-01A-01D-1494-08	54340082	140255258	40660002	27	13439											
SH3RF2	153769	broad.mit.edu	37	chr5	145393533	145393533	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agggcgccatatggtagagaTcagcaccccagtgctcatca	11	12	3	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr5:145393533T>G	uc003lnt.2	+	5	1206	c.968T>G	c.(967-969)ATC>AGC	p.I323S	SH3RF2_uc011dbl.1_Missense_Mutation_p.I323S	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	323							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGGTAGAGATCAGCACCCCA	0.567													G	145393533	G	G	145393533	3	3	190	1	0	0	0	0	1	0	0	0	14259	1435	50	5	982	5	SH3RF2	5	145393533	Missense_Mutation	SNP	T	TCGA-27-1838-01A-01D-1494-08	5138275	145393533	35521727	28	13440											
ITPR3	3710	broad.mit.edu	37	chr6	33644615	33644615	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcggagctggaccggctgcGgaccatggtggagaagtcag	18	9	1	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr6:33644615G>A	uc011drk.1	+	26	3572	c.3353G>A	c.(3352-3354)CGG>CAG	p.R1118Q		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1118	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GACCGGCTGCGGACCATGGTG	0.597													A	33644615	A	A	33644615	3	1	190	1	0	0	0	0	1	0	0	0	7922	1116	39	2	3455	2	ITPR3	6	33644615	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08		33644615	137470452	29	13441											
KCNK16	83795	broad.mit.edu	37	chr6	39282798	39282814	+	Frame_Shift_Del	DEL	TGGATATGGGGAAGTCC	-	-													tcagcttcccagtcctttctTggatatggggaagtcctggg					rs11756091	byFrequency	TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr6:39282798_39282814delTGGATATGGGGAAGTCC	uc003ooq.2	-	6	908_924	c.894_910delGGACTTCCCCATATCCA	c.(892-912)CAGGACTTCCCCATATCCAAGfs	p.Q298fs	KCNK17_uc003ooo.2_5'Flank|KCNK17_uc003oop.2_5'Flank|KCNK16_uc003oor.3_3'UTR|KCNK16_uc010jwy.2_Frame_Shift_Del_p.Q251fs	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	298_304	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						AGTCCTTTCTTGGATATGGGGAAGTCCTGGGGTGTGA	0.59													-	39282814	-	-	39282798	7	5	190	1	0	1	0	1	0	0	0	0	8063	1821	63	0	23	0	KCNK16	6	39282798	Frame_Shift_Del	DEL	TGGATATGGGGAAGTCC	TCGA-27-1838-01A-01D-1494-08	5638183	39282798	131832269	30	13442											
CUL9	23113	broad.mit.edu	37	chr6	43164484	43164484	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aacccaagagctgagagacaCgttgtttaggcactcaggga	12	9	1	3	rs142672693	byFrequency	TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr6:43164484C>A	uc003ouk.2	+	11	2762	c.2687C>A	c.(2686-2688)ACG>AAG	p.T896K	CUL9_uc003oul.2_Missense_Mutation_p.T896K|CUL9_uc010jyk.2_Missense_Mutation_p.T48K	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	896					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CTGAGAGACACGTTGTTTAGG	0.517													A	43164484	A	A	43164484	3	1	190	1	0	0	0	0	1	0	0	0	4061	536	19	5	2725	5	CUL9	6	43164484	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	3881686	43164484	127950583	31	13443											
ABCC10	89845	broad.mit.edu	37	chr6	43413522	43413522	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctgctgctcctgctgccGcctttgagcatcatgtacta	10	13	1	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr6:43413522G>A	uc003ouy.1	+	15	3431	c.3216G>A	c.(3214-3216)CCG>CCA	p.P1072P	ABCC10_uc003ouz.1_Silent_p.P1044P|ABCC10_uc010jyo.1_Silent_p.P178P	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1072	ABC transmembrane type-1 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TCCTGCTGCCGCCTTTGAGCA	0.662													A	43413522	A	A	43413522	2	1	190	1	0	0	0	0	0	0	0	1	50	1074	38	1		1	ABCC10	6	43413522	Silent	SNP	G	TCGA-27-1838-01A-01D-1494-08	249038	43413522	127701545	32	13444											
GCM1	8521	broad.mit.edu	37	chr6	52993580	52993580	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcagtcagatctgtgattccTcccagaccataactcttgga	7	12	4	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr6:52993580T>C	uc003pbp.2	-	6	944	c.735A>G	c.(733-735)GGA>GGG	p.G245G		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	245						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					CTGTGATTCCTCCCAGACCAT	0.453													C	52993580	C	C	52993580	2	2	190	1	0	0	0	0	0	0	0	1	6297	1538	54	4		4	GCM1	6	52993580	Silent	SNP	T	TCGA-27-1838-01A-01D-1494-08	9580058	52993580	118121487	33	13445											
LGSN	51557	broad.mit.edu	37	chr6	63990360	63990360	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccttggaataacgctttcGgcagctaacagaaggcgcca	11	11	0	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr6:63990360G>A	uc003peh.2	-	4	1130	c.1096C>T	c.(1096-1098)CGA>TGA	p.R366*	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	366					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	TAACGCTTTCGGCAGCTAACA	0.478													A	63990360	A	A	63990360	4	1	190	1	0	0	0	0	0	1	0	0	8759	1124	39	2	437	2	LGSN	6	63990360	Nonsense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	10996780	63990360	107124707	34	13446											
PHF3	23469	broad.mit.edu	37	chr6	64422167	64422167	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgacgagtcttagtctcagAggtaagccaccagatgtttc	10	9	2	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr6:64422167A>G	uc003pep.1	+	15	4709	c.4683A>G	c.(4681-4683)AGA>AGG	p.R1561R	PHF3_uc003pen.2_Silent_p.R1473R|PHF3_uc011dxs.1_Silent_p.R830R	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1561					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TTAGTCTCAGAGGTAAGCCAC	0.353													G	64422167	G	G	64422167	2	3	190	1	0	0	0	0	0	0	0	1	11836	301	11	4		4	PHF3	6	64422167	Silent	SNP	A	TCGA-27-1838-01A-01D-1494-08	431807	64422167	106692900	35	13447											
SEC63	11231	broad.mit.edu	37	chr6	108250659	108250659	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctggggttttaataaccGtaaacgataccacatacacc	8	10	0	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr6:108250659G>A	uc003psc.3	-	2	453	c.184C>T	c.(184-186)CGG>TGG	p.R62W		NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	62	Cytoplasmic (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TTTAATAACCGTAAACGATAC	0.299													A	108250659	A	A	108250659	3	1	190	1	0	0	0	0	1	0	0	0	14005	1144	40	1	2178	1	SEC63	6	108250659	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	43828492	108250659	62864408	36	13448											
SLC22A2	6582	broad.mit.edu	37	chr6	160663362	160663362	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acagctcagcattgaccaggCagactatctcataggccatt	8	12	2	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr6:160663362C>A	uc003qtf.2	-	8	1522	c.1352G>T	c.(1351-1353)TGC>TTC	p.C451F	SLC22A2_uc003qte.1_Missense_Mutation_p.C451F	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	451	Helical; (Potential).	Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations (By similarity).			body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		ATTGACCAGGCAGACTATCTC	0.438													A	160663362	A	A	160663362	3	1	190	1	0	0	0	0	1	0	0	0	14450	710	25	5	331	5	SLC22A2	6	160663362	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	52412703	160663362	10451705	37	13449											
DGKB	1607	broad.mit.edu	37	chr7	14733777	14733777	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcctccagagacacggttcCatcatgatcatagtcaattt	6	11	3	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:14733777C>T	uc003ssz.2	-	8	821	c.634G>A	c.(634-636)GGA>AGA	p.G212R	DGKB_uc011jxt.1_Missense_Mutation_p.G205R|DGKB_uc003sta.2_Missense_Mutation_p.G212R|DGKB_uc011jxu.1_Missense_Mutation_p.G212R|DGKB_uc011jxv.1_Missense_Mutation_p.G212R	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	212	EF-hand 2.|2 (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	GACACGGTTCCATCATGATCA	0.418													T	14733777	T	T	14733777	3	4	190	1	0	0	0	0	1	0	0	0	4466	603	21	3	1867	3	DGKB	7	14733777	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08		14733777	144404886	38	13450											
TRA2A	29896	broad.mit.edu	37	chr7	23552560	23552560	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	atacacaaaagcaaatcctcGagatcgcccagttcgctgat	7	12	0	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:23552560G>C	uc003swi.2	-	4	692	c.478C>G	c.(478-480)CGA>GGA	p.R160G	TRA2A_uc011jzb.1_RNA|TRA2A_uc011jzc.1_Missense_Mutation_p.R59G|TRA2A_uc011jzd.1_Missense_Mutation_p.R59G|TRA2A_uc010kuo.1_RNA	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	transformer-2 alpha	160	RRM.				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			ovary(1)	1						GCAAATCCTCGAGATCGCCCA	0.378													C	23552560	C	C	23552560	3	2	190	1	0	0	0	0	1	0	0	0	16430	1066	37	5	390	5	TRA2A	7	23552560	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	8818783	23552560	135586103	39	13451											
GHRHR	2692	broad.mit.edu	37	chr7	31009513	31009513	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgggattgtactatcactggCtggtctgagccctttccacc	10	13	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:31009513C>A	uc003tbx.2	+	4	348	c.300C>A	c.(298-300)GGC>GGA	p.G100G	GHRHR_uc003tbw.1_Silent_p.G100G|GHRHR_uc003tby.2_Silent_p.G36G|GHRHR_uc003tbz.2_Translation_Start_Site	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	100	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	CTATCACTGGCTGGTCTGAGC	0.582													A	31009513	A	A	31009513	2	1	190	1	0	0	0	0	0	0	0	1	6373	784	28	5		5	GHRHR	7	31009513	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08	7456953	31009513	128129150	40	13452											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:55221822C>A	uc003tqk.2	+	7	1112	c.866C>A	c.(865-867)GCC>GAC	p.A289D	EGFR_uc003tqh.2_Missense_Mutation_p.A289D|EGFR_uc003tqi.2_Missense_Mutation_p.A289D|EGFR_uc003tqj.2_Missense_Mutation_p.A289D|EGFR_uc010kzg.1_Missense_Mutation_p.A244D|EGFR_uc011kco.1_Missense_Mutation_p.A236D|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55221822	A	A	55221822	3	1	190	1	0	0	0	0	1	0	0	0	4967	739	26	5	892	5	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	24212309	55221822	103916841	41	13453											
PCLO	27445	broad.mit.edu	37	chr7	82474620	82474620	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcttctttttgctcactgaGggggaccctggttgcccagg	13	11	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:82474620G>A	uc003uhx.2	-	13	14302	c.14013C>T	c.(14011-14013)CCC>CCT	p.P4671P	PCLO_uc003uhv.2_Silent_p.P4671P|PCLO_uc003uht.1_Silent_p.P122P|PCLO_uc003uhu.1_Silent_p.P101P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4559					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGCTCACTGAGGGGGACCCTG	0.488													A	82474620	A	A	82474620	2	1	190	1	0	0	0	0	0	0	0	1	11583	987	35	3		3	PCLO	7	82474620	Silent	SNP	G	TCGA-27-1838-01A-01D-1494-08	27252798	82474620	76664043	42	13454											
STEAP4	79689	broad.mit.edu	37	chr7	87913202	87913202	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaatgcttttaccacgtggGctcctggcaccaaatgagca	9	11	0	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:87913202G>A	uc003ujs.2	-	2	488	c.383C>T	c.(382-384)GCC>GTC	p.A128V	STEAP4_uc010lek.2_Missense_Mutation_p.A128V|STEAP4_uc003ujt.2_Missense_Mutation_p.A128V	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	128					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					TACCACGTGGGCTCCTGGCAC	0.428													A	87913202	A	A	87913202	3	1	190	1	0	0	0	0	1	0	0	0	15279	1203	42	3	1012	3	STEAP4	7	87913202	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	5438582	87913202	71225461	43	13455											
ZNF655	79027	broad.mit.edu	37	chr7	99170930	99170930	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	acatcttattcagcatcaaaGaattcacacaggagagaaag	7	8	4	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:99170930G>T	uc003urh.2	+	3	1592	c.1199G>T	c.(1198-1200)AGA>ATA	p.R400I	ZNF655_uc010lga.2_Missense_Mutation_p.R435I|ZNF655_uc010lgc.2_Missense_Mutation_p.R435I|ZNF655_uc003urj.2_Missense_Mutation_p.R400I|ZNF655_uc003urk.2_Missense_Mutation_p.R237I|ZNF655_uc010lgd.2_Missense_Mutation_p.R237I	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	400	C2H2-type 5.				G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CAGCATCAAAGAATTCACACA	0.353													T	99170930	T	T	99170930	3	4	190	1	0	0	0	0	1	0	0	0	18065	942	33	5	1736	5	ZNF655	7	99170930	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	11257728	99170930	59967733	44	13456											
RELN	5649	broad.mit.edu	37	chr7	103368622	103368622	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catgcataatcgcgccacacTgttctccagtctcacagttg	7	14	2	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:103368622T>C	uc003vca.2	-	7	849	c.689A>G	c.(688-690)CAG>CGG	p.Q230R	RELN_uc010liz.2_Missense_Mutation_p.Q230R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	230					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CGCGCCACACTGTTCTCCAGT	0.458													C	103368622	C	C	103368622	3	2	190	1	0	0	0	0	1	0	0	0	13220	1580	55	4	9929	4	RELN	7	103368622	Missense_Mutation	SNP	T	TCGA-27-1838-01A-01D-1494-08	4197692	103368622	55770041	45	13457											
TAS2R16	50833	broad.mit.edu	37	chr7	122635067	122635067	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgaccagtgctatgatgttGtatctgcttggtcagtgatg	13	6	2	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:122635067G>T	uc003vkl.1	-	1	688	c.622C>A	c.(622-624)CAA>AAA	p.Q208K		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	208	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						CTATGATGTTGTATCTGCTTG	0.463													T	122635067	T	T	122635067	3	4	190	1	0	0	0	0	1	0	0	0	15566	1386	48	5	257	5	TAS2R16	7	122635067	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	19266445	122635067	36503596	46	13458											
TRPV6	55503	broad.mit.edu	37	chr7	142575732	142575732	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgagcaacttgttcagggccTggacatcattatctttggca	10	9	3	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr7:142575732T>C	uc003wbx.1	-	2	392	c.176A>G	c.(175-177)CAG>CGG	p.Q59R	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_5'UTR	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	59	ANK 1.|Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GTTCAGGGCCTGGACATCATT	0.493													C	142575732	C	C	142575732	3	2	190	1	0	0	0	0	1	0	0	0	16597	1580	55	4	2057	4	TRPV6	7	142575732	Missense_Mutation	SNP	T	TCGA-27-1838-01A-01D-1494-08	19940665	142575732	16562931	47	13459											
DCTN6	10671	broad.mit.edu	37	chr8	30040689	30040689	+	Nonstop_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaactccagtaaagaactaAgaacagtgtataacatgaag	7	7	1	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr8:30040689A>C	uc003xhy.2	+	7	660	c.573A>C	c.(571-573)TAA>TAC	p.*191Y		NM_006571	NP_006562	O00399	DCTN6_HUMAN	dynactin 6	191						centrosome	transferase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.099)|Kidney(114;0.119)		TAAAGAACTAAGAACAGTGTA	0.378													C	30040689	C	C	30040689	4	2	190	1	0	0	0	0	0	0	0	0	4311	79	3	5	599	5	DCTN6	8	30040689	Nonstop_Mutation	SNP	A	TCGA-27-1838-01A-01D-1494-08		30040689	116323333	48	13460											
PLEKHA2	59339	broad.mit.edu	37	chr8	38826181	38826181	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccaggccctcaagtgccaCcccagagtaagtcacttcct	8	16	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr8:38826181C>T	uc003xmi.3	+	11	1143	c.909C>T	c.(907-909)CAC>CAT	p.H303H	PLEKHA2_uc011lce.1_Silent_p.H253H	NM_021623	NP_067636	Q9HB19	PKHA2_HUMAN	pleckstrin homology domain containing, family A	303					positive regulation of cell-matrix adhesion	cytoplasm|nucleus|plasma membrane|protein complex	fibronectin binding|laminin binding				0		all_lung(54;0.0413)|Lung NSC(58;0.115)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;4.68e-08)|COAD - Colon adenocarcinoma(9;0.235)			TCAAGTGCCACCCCAGAGTAA	0.498													T	38826181	T	T	38826181	2	4	190	1	0	0	0	0	0	0	0	1	12056	506	18	3		3	PLEKHA2	8	38826181	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08	8785492	38826181	107537841	49	13461											
ANK1	286	broad.mit.edu	37	chr8	41543721	41543721	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaggttcagcaaggccacacTctgctccaacagggagttgg	13	11	2	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr8:41543721T>A	uc003xok.2	-	36	4423	c.4339A>T	c.(4339-4341)AGT>TGT	p.S1447C	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.S763C|ANK1_uc003xoi.2_Missense_Mutation_p.S1447C|ANK1_uc003xoj.2_Missense_Mutation_p.S1447C|ANK1_uc003xol.2_Missense_Mutation_p.S1447C|ANK1_uc003xom.2_Missense_Mutation_p.S1488C	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1447	55 kDa regulatory domain.|Death.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AAGGCCACACTCTGCTCCAAC	0.557													A	41543721	A	A	41543721	3	1	190	1	0	0	0	0	1	0	0	0	620	1551	54	5	1660	5	ANK1	8	41543721	Missense_Mutation	SNP	T	TCGA-27-1838-01A-01D-1494-08	2717540	41543721	104820301	50	13462											
IL7	3574	broad.mit.edu	37	chr8	79645969	79645969	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cagtgttctttagtgcccatCaaaattttattccaacaagt	5	9	2	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr8:79645969C>T	uc003ybg.2	-	6	1114	c.513G>A	c.(511-513)TTG>TTA	p.L171L	IL7_uc003ybe.2_Silent_p.L86L|IL7_uc011lfm.1_RNA|IL7_uc003ybh.2_RNA|IL7_uc003ybi.3_RNA	NM_000880	NP_000871	P13232	IL7_HUMAN	interleukin 7 precursor	171					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding				0						TAGTGCCCATCAAAATTTTAT	0.323													T	79645969	T	T	79645969	2	4	190	1	0	0	0	0	0	0	0	1	7704	825	29	3		3	IL7	8	79645969	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08	38102248	79645969	66718053	51	13463											
RGS22	26166	broad.mit.edu	37	chr8	101016271	101016271	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cattatcccaatattctgttCgtttagagacgttagagagt	8	7	1	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr8:101016271C>T	uc003yjb.1	-	17	2705	c.2510G>A	c.(2509-2511)CGA>CAA	p.R837Q	RGS22_uc003yja.1_Missense_Mutation_p.R656Q|RGS22_uc003yjc.1_Missense_Mutation_p.R825Q|RGS22_uc011lgz.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	837					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ATATTCTGTTCGTTTAGAGAC	0.353													T	101016271	T	T	101016271	3	4	190	1	0	0	0	0	1	0	0	0	13305	884	31	2	1328	2	RGS22	8	101016271	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	21370302	101016271	45347751	52	13464											
SMARCA2	6595	broad.mit.edu	37	chr9	2029232	2029232	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gacttcccacaggaaggcatGcatcaaatgcataaggtaag	10	9	1	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr9:2029232G>C	uc003zhc.2	+	2	309	c.210G>C	c.(208-210)ATG>ATC	p.M70I	SMARCA2_uc003zhd.2_Missense_Mutation_p.M70I|SMARCA2_uc010mha.2_Missense_Mutation_p.M61I	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	70					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AGGAAGGCATGCATCAAATGC	0.493													C	2029232	C	C	2029232	3	2	190	1	0	0	0	0	1	0	0	0	14769	1319	46	5	212	5	SMARCA2	9	2029232	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08		2029232	139184199	53	13465											
IL33	90865	broad.mit.edu	37	chr9	6251142	6251142	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcccatccggtctgcaggtAgaaagcacaaaagacatctg	9	11	2	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr9:6251142A>G	uc003zjt.2	+	4	277	c.220A>G	c.(220-222)AGA>GGA	p.R74G	IL33_uc011lmg.1_Missense_Mutation_p.R74G|IL33_uc011lmh.1_Intron|IL33_uc003zju.1_Missense_Mutation_p.R74G	NM_033439	NP_254274	O95760	IL33_HUMAN	interleukin 33 precursor	74					positive regulation of chemokine secretion|positive regulation of inflammatory response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity				0		Acute lymphoblastic leukemia(23;0.158)|Prostate(43;0.167)		GBM - Glioblastoma multiforme(50;0.0161)|Lung(218;0.105)		GTCTGCAGGTAGAAAGCACAA	0.493													G	6251142	G	G	6251142	3	3	190	1	0	0	0	0	1	0	0	0	7693	412	15	4	230	4	IL33	9	6251142	Missense_Mutation	SNP	A	TCGA-27-1838-01A-01D-1494-08	4221910	6251142	134962289	54	13466											
ZNF484	83744	broad.mit.edu	37	chr9	95610513	95610513	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	atataaggttatgataggctCcaaattctttccacacgagt	7	8	1	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr9:95610513C>A	uc004asu.1	-	5	705	c.556G>T	c.(556-558)GAG>TAG	p.E186*	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Nonsense_Mutation_p.E188*|ZNF484_uc010mrb.1_Nonsense_Mutation_p.E150*|ZNF484_uc004asv.1_Nonsense_Mutation_p.E150*	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGATAGGCTCCAAATTCTTT	0.343													A	95610513	A	A	95610513	4	1	190	1	0	0	0	0	0	1	0	0	17934	864	30	5	2006	5	ZNF484	9	95610513	Nonsense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	89359371	95610513	45602918	55	13467											
ZNF462	58499	broad.mit.edu	37	chr9	109687562	109687562	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atcgacgtagcatctctcgtCacatagaaaacatccactta	5	12	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr9:109687562C>G	uc004bcz.2	+	3	1658	c.1369C>G	c.(1369-1371)CAC>GAC	p.H457D	ZNF462_uc010mto.2_Missense_Mutation_p.H305D|ZNF462_uc004bda.2_Missense_Mutation_p.H305D	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	457	C2H2-type 4.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CATCTCTCGTCACATAGAAAA	0.438													G	109687562	G	G	109687562	3	3	190	1	0	0	0	0	1	0	0	0	17923	826	29	5	1375	5	ZNF462	9	109687562	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	14077049	109687562	31525869	56	13468											
FAM129B	64855	broad.mit.edu	37	chr9	130289580	130289580	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagaggttccccgagaagaCgatgcgctcgtccagtggca	14	11	0	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr9:130289580C>T	uc004brh.2	-	3	410	c.208G>A	c.(208-210)GTC>ATC	p.V70I	FAM129B_uc004bri.2_Missense_Mutation_p.V57I|FAM129B_uc004brj.3_Missense_Mutation_p.V70I	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	70	PH.						protein binding				0						CCCGAGAAGACGATGCGCTCG	0.637													T	130289580	T	T	130289580	3	4	190	1	0	0	0	0	1	0	0	0	5437	536	19	1	2080	1	FAM129B	9	130289580	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	20602018	130289580	10923851	57	13469											
PAEP	5047	broad.mit.edu	37	chr9	138453719	138453719	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gccatggacatcccccagacCaagcaggacctggagctccc	10	17	0	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr9:138453719C>A	uc004cge.1	+	1	116	c.72C>A	c.(70-72)ACC>ACA	p.T24T	PAEP_uc010naw.1_Silent_p.T24T|PAEP_uc010naz.2_RNA|PAEP_uc010nay.2_Silent_p.T24T|PAEP_uc010nba.1_Silent_p.T24T|PAEP_uc004cgd.1_Silent_p.T24T|PAEP_uc011mdp.1_Silent_p.T24T|PAEP_uc004cgg.1_Silent_p.T24T|PAEP_uc010nbc.1_Silent_p.T24T|PAEP_uc004cgf.1_Silent_p.T24T	NM_001018049	NP_001018059	P09466	PAEP_HUMAN	glycodelin precursor	24					multicellular organismal development	extracellular region	binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		TCCCCCAGACCAAGCAGGACC	0.682													A	138453719	A	A	138453719	2	1	190	1	0	0	0	0	0	0	0	1	11382	581	21	5		5	PAEP	9	138453719	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08	8164139	138453719	2759712	58	13470											
ADARB2	105	broad.mit.edu	37	chr10	1262895	1262895	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagccgtgggcctcacctggCgatcttgtccgtgcaggaca	13	13	2	0	rs142663256	byFrequency	TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr10:1262895C>T	uc009xhq.2	-	7	2052	c.1678G>A	c.(1678-1680)GCC>ACC	p.A560T		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	560	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CCTCACCTGGCGATCTTGTCC	0.677													T	1262895	T	T	1262895	3	4	190	1	0	0	0	0	1	0	0	0	283	768	27	1	557	1	ADARB2	10	1262895	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08		1262895	134271852	59	13471											
GDF10	2662	broad.mit.edu	37	chr10	48429388	48429388	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcaggtgctggcgtgtgggCgggcccaggggcagcgggcg	23	10	0	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr10:48429388C>T	uc001jfb.2	-	2	954	c.498G>A	c.(496-498)CCG>CCA	p.P166P	GDF10_uc009xnp.2_Silent_p.P165P|GDF10_uc009xnq.1_Silent_p.P166P	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	166					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						GGCGTGTGGGCGGGCCCAGGG	0.726													T	48429388	T	T	48429388	2	4	190	1	0	0	0	0	0	0	0	1	6311	755	27	1		1	GDF10	10	48429388	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08	47166493	48429388	87105359	60	13472											
MAT1A	4143	broad.mit.edu	37	chr10	82034333	82034333	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcaccacatccagcagctctCgctctgtcttctgagaggtt	9	14	4	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr10:82034333C>T	uc001kbw.2	-	8	1283	c.1028G>A	c.(1027-1029)CGA>CAA	p.R343Q		NM_000429	NP_000420	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	343					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	CAGCAGCTCTCGCTCTGTCTT	0.557													T	82034333	T	T	82034333	3	4	190	1	0	0	0	0	1	0	0	0	9329	884	31	2	167	2	MAT1A	10	82034333	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	33604945	82034333	53500414	61	13473											
PTEN	5728	broad.mit.edu	37	chr10	89720670	89720671	+	Missense_Mutation	DNP	GG	CT	CT													ggacaaaatgtttcacttttGggtaaatacattcttcatac							TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr10:89720670_89720671GG>CT	uc001kfb.2	+	9	1852_1853	c.821_822GG>CT	c.(820-822)TGG>TCT	p.W274S		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	274	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.W274*(6)|p.R55fs*1(4)|p.?(2)|p.W274fs*2(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.D268_F279>VGQNVSLLGKYI(2)|p.G165_*404del(1)|p.W274G(1)|p.W274_F341del(1)|p.W274R(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTTCACTTTTGGGTAAATACAT	0.243		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			CT	89720671	CT	CT	89720670	3	2	190	1	0	0	0	0	1	0	0	0	12738	1357	47	5	851	5	PTEN	10	89720670	Missense_Mutation	DNP	GG	TCGA-27-1838-01A-01D-1494-08	7686337	89720670	45814077	62	13474											
AFAP1L2	84632	broad.mit.edu	37	chr10	116062141	116062141	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacaatacaggagaccctatCggcatccacatagtcgtagg	9	12	0	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr10:116062141C>T	uc001lbn.2	-	12	1688	c.1387G>A	c.(1387-1389)GAT>AAT	p.D463N	AFAP1L2_uc001lbo.2_Missense_Mutation_p.D463N|AFAP1L2_uc010qse.1_Missense_Mutation_p.D516N|AFAP1L2_uc001lbp.2_Missense_Mutation_p.D491N|AFAP1L2_uc001lbr.1_Missense_Mutation_p.D463N|AFAP1L2_uc001lbm.2_5'Flank|AFAP1L2_uc010qsd.1_Missense_Mutation_p.D29N|AFAP1L2_uc001lbq.1_5'Flank	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	463					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GAGACCCTATCGGCATCCACA	0.527													T	116062141	T	T	116062141	3	4	190	1	0	0	0	0	1	0	0	0	355	884	31	2	1101	2	AFAP1L2	10	116062141	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	26341471	116062141	19472606	63	13475											
C11orf35	256329	broad.mit.edu	37	chr11	556891	556891	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgcttgctcggaggaagcgCggtggtcccggggcgggtgc	21	11	0	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr11:556891C>T	uc001lpx.2	-	8	983	c.920G>A	c.(919-921)CGC>CAC	p.R307H	uc001lpy.2_5'Flank|uc001lpz.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	307										pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAGGAAGCGCGGTGGTCCCG	0.692													T	556891	T	T	556891	3	4	190	1	0	0	0	0	1	0	0	0	1638	768	27	1	1012	1	C11orf35	11	556891	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08		556891	134449625	64	13476											
OR4A15	81328	broad.mit.edu	37	chr11	55135749	55135749	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggttgtatggctcaacttttTatggatcatttatttgctgg	10	5	2	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr11:55135749T>C	uc010rif.1	+	1	390	c.390T>C	c.(388-390)TTT>TTC	p.F130F		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	130	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTCAACTTTTTATGGATCATT	0.403													C	55135749	C	C	55135749	2	2	190	1	0	0	0	0	0	0	0	1	11040	1751	61	4		4	OR4A15	11	55135749	Silent	SNP	T	TCGA-27-1838-01A-01D-1494-08	54578858	55135749	79870767	65	13477											
OR5D16	390144	broad.mit.edu	37	chr11	55606949	55606950	+	Frame_Shift_Ins	INS	-	CACCT	CACCT													gggcaccgcaaagtcttctcINScacctgtgcctcccacctga							TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr11:55606949_55606950insCACCT	uc010rio.1	+	1	722_723	c.722_723insCACCT	c.(721-723)TCCfs	p.S241fs		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				AAAGTCTTCTCCACCTGTGCCT	0.49													CACCT	55606950	CACCT	CACCT	55606949	7	5	190	1	0	1	1	0	0	0	0	0	11156	855	30	0	724	0	OR5D16	11	55606949	Frame_Shift_Ins	INS	-	TCGA-27-1838-01A-01D-1494-08	471200	55606949	79399567	66	13478											
OR8H2	390151	broad.mit.edu	37	chr11	55873210	55873210	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcctgaaaattaattccaCttcaggaaagcagaaagctt	6	9	1	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr11:55873210C>T	uc010riy.1	+	1	692	c.692C>T	c.(691-693)ACT>ATT	p.T231I		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					ATTAATTCCACTTCAGGAAAG	0.373										HNSCC(53;0.14)			T	55873210	T	T	55873210	3	4	190	1	0	0	0	0	1	0	0	0	11238	565	20	3	694	3	OR8H2	11	55873210	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	266261	55873210	79133306	67	13479											
ZP1	22917	broad.mit.edu	37	chr11	60637220	60637220	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atacctcccaaggctctggcCatgcctttcccagcccactg	7	18	1	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr11:60637220C>G	uc001nqd.2	+	3	549	c.529C>G	c.(529-531)CAT>GAT	p.H177D	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	177	Extracellular (Potential).				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						AGGCTCTGGCCATGCCTTTCC	0.627													G	60637220	G	G	60637220	3	3	190	1	0	0	0	0	1	0	0	0	18212	594	21	5	539	5	ZP1	11	60637220	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	4764010	60637220	74369296	68	13480											
FTH1	2495	broad.mit.edu	37	chr11	61732280	61732280	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gattcgggcgctcccatcttGcgcaagttggtcacgtggtc	13	12	2	0	rs11554851		TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr11:61732280G>C	uc001nsu.2	-	4	706	c.471C>G	c.(469-471)CGC>CGG	p.R157R		NM_002032	NP_002023	P02794	FRIH_HUMAN	ferritin, heavy polypeptide 1	157	Ferritin-like diiron.				cell proliferation|cellular membrane organization|immune response|intracellular sequestering of iron ion|iron ion transport|negative regulation of cell proliferation|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|ferroxidase activity|protein binding			ovary(1)	1					Iron Dextran(DB00893)	CTCCCATCTTGCGCAAGTTGG	0.493													C	61732280	C	C	61732280	2	2	190	1	0	0	0	0	0	0	0	1	6082	1306	46	5		5	FTH1	11	61732280	Silent	SNP	G	TCGA-27-1838-01A-01D-1494-08	1095060	61732280	73274236	69	13481											
PGR	5241	broad.mit.edu	37	chr11	100933263	100933263	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtcagcaaagaactggaggtGtcaggttttgtgttgtcatg	14	5	3	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr11:100933263G>T	uc001pgh.2	-	4	2870	c.2127C>A	c.(2125-2127)GAC>GAA	p.D709E	PGR_uc001pgg.2_Missense_Mutation_p.D90E|PGR_uc001pgi.2_Intron|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	709	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	AACTGGAGGTGTCAGGTTTTG	0.408													T	100933263	T	T	100933263	3	4	190	1	0	0	0	0	1	0	0	0	11805	1368	48	5	694	5	PGR	11	100933263	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	39200983	100933263	34073253	70	13482											
CDCA3	83461	broad.mit.edu	37	chr12	6959664	6959664	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcataggtgtccgtgcaaTaccaagagtaggagagcggg	14	8	1	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr12:6959664T>C	uc001qrg.2	-	3	345	c.217A>G	c.(217-219)ATT>GTT	p.I73V	CDCA3_uc001qre.2_Missense_Mutation_p.I73V|uc001qrf.1_5'Flank|USP5_uc001qri.3_5'Flank|USP5_uc001qrh.3_5'Flank	NM_031299	NP_112589	Q99618	CDCA3_HUMAN	cell division cycle associated 3	73					cell division|mitosis	cytosol					0						GTCCGTGCAATACCAAGAGTA	0.547													C	6959664	C	C	6959664	3	2	190	1	0	0	0	0	1	0	0	0	3087	1406	49	4	605	4	CDCA3	12	6959664	Missense_Mutation	SNP	T	TCGA-27-1838-01A-01D-1494-08		6959664	126892231	71	13483											
ABCC9	10060	broad.mit.edu	37	chr12	21960380	21960380	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atagctgtctctgtccaacgCtaaaattctccccaccttca	4	15	3	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr12:21960380C>G	uc001rfi.1	-	36	4369	c.4349G>C	c.(4348-4350)AGC>ACC	p.S1450T	ABCC9_uc001rfh.2_Missense_Mutation_p.S1450T|ABCC9_uc001rfj.1_Missense_Mutation_p.S1414T|ABCC9_uc001rfg.2_5'UTR	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1450	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTGTCCAACGCTAAAATTCTC	0.433													G	21960380	G	G	21960380	3	3	190	1	0	0	0	0	1	0	0	0	59	797	28	5	454	5	ABCC9	12	21960380	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	15000716	21960380	111891515	72	13484											
ABCC9	10060	broad.mit.edu	37	chr12	21968784	21968784	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acacacagatcatgtatcttGatctccccttcttgtggcca	6	13	4	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr12:21968784G>C	uc001rfi.1	-	32	3956	c.3936C>G	c.(3934-3936)ATC>ATG	p.I1312M	ABCC9_uc001rfh.2_Missense_Mutation_p.I1312M|ABCC9_uc001rfj.1_Missense_Mutation_p.I1276M	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1312	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CATGTATCTTGATCTCCCCTT	0.403													C	21968784	C	C	21968784	3	2	190	1	0	0	0	0	1	0	0	0	59	1280	45	5	883	5	ABCC9	12	21968784	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	8404	21968784	111883111	73	13485											
ABCC9	10060	broad.mit.edu	37	chr12	21970190	21970190	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcttcactgcacccatctGgacctccaggtcagccaagt	7	16	4	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr12:21970190G>A	uc001rfi.1	-	31	3843	c.3823C>T	c.(3823-3825)CAG>TAG	p.Q1275*	ABCC9_uc001rfh.2_Nonsense_Mutation_p.Q1275*|ABCC9_uc001rfj.1_Nonsense_Mutation_p.Q1239*	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1275	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCACCCATCTGGACCTCCAGG	0.368													A	21970190	A	A	21970190	4	1	190	1	0	0	0	0	0	1	0	0	59	1357	47	3	1000	3	ABCC9	12	21970190	Nonsense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	1406	21970190	111881705	74	13486											
ABCC9	10060	broad.mit.edu	37	chr12	21981913	21981913	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtcctgacctccagccatctGttggcagctgagagaaataa	10	11	1	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr12:21981913G>T	uc001rfi.1	-	29	3668	c.3648C>A	c.(3646-3648)AAC>AAA	p.N1216K	ABCC9_uc001rfh.2_Missense_Mutation_p.N1216K|ABCC9_uc001rfj.1_Missense_Mutation_p.N1180K	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1216	Extracellular (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCAGCCATCTGTTGGCAGCTG	0.423													T	21981913	T	T	21981913	3	4	190	1	0	0	0	0	1	0	0	0	59	1368	48	5	1183	5	ABCC9	12	21981913	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	11723	21981913	111869982	75	13487											
OR6C6	283365	broad.mit.edu	37	chr12	55688288	55688288	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tatgtcatggagacaacaatCatgtgggaagtacaggtgga	13	5	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr12:55688288C>G	uc010sph.1	-	1	729	c.729G>C	c.(727-729)ATG>ATC	p.M243I		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						AGACAACAATCATGTGGGAAG	0.368													G	55688288	G	G	55688288	3	3	190	1	0	0	0	0	1	0	0	0	11194	826	29	5	217	5	OR6C6	12	55688288	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	33706375	55688288	78163607	76	13488											
NUP107	57122	broad.mit.edu	37	chr12	69115670	69115670	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagtttgggcctacttccGggtgatggtggacagtctgg	15	9	1	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr12:69115670G>A	uc001suf.2	+	16	1476	c.1361G>A	c.(1360-1362)CGG>CAG	p.R454Q	NUP107_uc001sug.2_Missense_Mutation_p.R301Q|NUP107_uc010stj.1_Missense_Mutation_p.R425Q	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	454					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			GCCTACTTCCGGGTGATGGTG	0.448													A	69115670	A	A	69115670	3	1	190	1	0	0	0	0	1	0	0	0	10753	1116	39	2	1423	2	NUP107	12	69115670	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	13427382	69115670	64736225	77	13489											
FLT3	2322	broad.mit.edu	37	chr13	28636174	28636174	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgagctctggggtctcaaCgcacacccgaggtcttccgg	12	15	3	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr13:28636174C>T	uc001urw.2	-	3	280	c.198G>A	c.(196-198)GCG>GCA	p.A66A	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Silent_p.A66A	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	66	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.599_560>LTGSSDNEYFYVDFREYEY(1)		haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GGGGTCTCAACGCACACCCGA	0.537			Mis|O		AML|ALL								T	28636174	T	T	28636174	2	4	190	1	0	0	0	0	0	0	0	1	5942	523	19	1		1	FLT3	13	28636174	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08		28636174	86533704	78	13490											
RNASE11	122651	broad.mit.edu	37	chr14	21052270	21052270	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcacttctgtggagctgcGgatgaagttattgctccact	10	10	2	1	rs144501463	byFrequency	TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr14:21052270G>A	uc010ahv.2	-	2	549	c.364C>T	c.(364-366)CGC>TGC	p.R122C	RNASE11_uc010ahx.2_Missense_Mutation_p.R122C|RNASE11_uc010ahw.2_Missense_Mutation_p.R122C|RNASE11_uc001vxs.2_Missense_Mutation_p.R122C	NM_145250	NP_660293	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	122						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(3)	3	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		GTGGAGCTGCGGATGAAGTTA	0.488													A	21052270	A	A	21052270	3	1	190	1	0	0	0	0	1	0	0	0	13401	1116	39	2	239	2	RNASE11	14	21052270	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08		21052270	86297270	79	13491											
GALNTL1	57452	broad.mit.edu	37	chr14	69795188	69795188	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgatccggtcccgagtgcGtggggcggacgtggctgcag	19	11	0	1	rs61748871	byFrequency	TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr14:69795188G>A	uc010aqu.1	+	6	683	c.590G>A	c.(589-591)CGT>CAT	p.R197H	GALNTL1_uc001xla.1_Missense_Mutation_p.R197H|GALNTL1_uc001xlb.1_Missense_Mutation_p.R197H	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	197	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		TCCCGAGTGCGTGGGGCGGAC	0.632													A	69795188	A	A	69795188	3	1	190	1	0	0	0	0	1	0	0	0	6221	1145	40	1	612	1	GALNTL1	14	69795188	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	48742918	69795188	37554352	80	13492											
FBLN5	10516	broad.mit.edu	37	chr14	92343924	92343924	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggcttgcatttggaagatGtcagcgggaacggagcgtcc	16	8	1	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr14:92343924G>A	uc001xzx.3	-	10	1565	c.1092C>T	c.(1090-1092)GAC>GAT	p.D364D	FBLN5_uc010aud.2_Silent_p.D369D|FBLN5_uc010aue.2_Silent_p.D405D|FBLN5_uc001xzw.2_5'Flank	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	364					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				TTTGGAAGATGTCAGCGGGAA	0.537													A	92343924	A	A	92343924	2	1	190	1	0	0	0	0	0	0	0	1	5700	1368	48	3		3	FBLN5	14	92343924	Silent	SNP	G	TCGA-27-1838-01A-01D-1494-08	22548736	92343924	15005616	81	13493											
PAPOLA	10914	broad.mit.edu	37	chr14	96991694	96991694	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttggaggaaaaatttttacAtttggatcttacagattagg	10	3	1	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr14:96991694A>G	uc001yfq.2	+	4	507	c.297A>G	c.(295-297)ACA>ACG	p.T99T	PAPOLA_uc001yfo.2_Silent_p.T99T|PAPOLA_uc001yfp.2_Silent_p.T99T|PAPOLA_uc001yfr.2_Silent_p.T99T|PAPOLA_uc010twv.1_Silent_p.T99T|PAPOLA_uc010avp.2_5'UTR	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	99					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		AAATTTTTACATTTGGATCTT	0.323													G	96991694	G	G	96991694	2	3	190	1	0	0	0	0	0	0	0	1	11429	204	8	4		4	PAPOLA	14	96991694	Silent	SNP	A	TCGA-27-1838-01A-01D-1494-08	4647770	96991694	10357846	82	13494											
KIF26A	26153	broad.mit.edu	37	chr14	104642036	104642036	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccccagaagagcctgggggaGggggcactgatggagtggca	19	9	0	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr14:104642036G>T	uc001yos.3	+	12	2911	c.2911G>T	c.(2911-2913)GGG>TGG	p.G971W		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	971					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GCCTGGGGGAGGGGGCACTGA	0.701													T	104642036	T	T	104642036	3	4	190	1	0	0	0	0	1	0	0	0	8294	1000	35	5	2957	5	KIF26A	14	104642036	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	7650342	104642036	2707504	83	13495											
TUBGCP5	114791	broad.mit.edu	37	chr15	22868917	22868917	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agatcaattgattaaaattcActataggtatctgtcaacca	5	7	4	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr15:22868917A>G	uc001yur.3	+	20	2919	c.2789A>G	c.(2788-2790)CAC>CGC	p.H930R	TUBGCP5_uc001yuq.2_Missense_Mutation_p.H930R	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	930					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		ATTAAAATTCACTATAGGTAT	0.453													G	22868917	G	G	22868917	3	3	190	1	0	0	0	0	1	0	0	0	16766	159	6	4	2867	4	TUBGCP5	15	22868917	Missense_Mutation	SNP	A	TCGA-27-1838-01A-01D-1494-08		22868917	79662475	84	13496											
C15orf2	23742	broad.mit.edu	37	chr15	24922713	24922713	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgcatctgcccacctaaccTcacagactgcggtagaccct	7	17	2	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr15:24922713T>C	uc001ywo.2	+	1	2173	c.1699T>C	c.(1699-1701)TCA>CCA	p.S567P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	567					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCACCTAACCTCACAGACTGC	0.488													C	24922713	C	C	24922713	3	2	190	1	0	0	0	0	1	0	0	0	1784	1551	54	4	1701	4	C15orf2	15	24922713	Missense_Mutation	SNP	T	TCGA-27-1838-01A-01D-1494-08	2053796	24922713	77608679	85	13497											
RPAP1	26015	broad.mit.edu	37	chr15	41810311	41810311	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcaccagtaaccagggtccGgaagtagagctgaaggaggg	16	9	0	2	rs141969064		TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr15:41810311G>A	uc001zod.2	-	23	3989	c.3865C>T	c.(3865-3867)CGG>TGG	p.R1289W	RPAP1_uc001zoc.2_Missense_Mutation_p.R308W	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1289						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		ACCAGGGTCCGGAAGTAGAGC	0.582													A	41810311	A	A	41810311	3	1	190	1	0	0	0	0	1	0	0	0	13541	1115	39	2	328	2	RPAP1	15	41810311	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	16887598	41810311	60721081	86	13498											
DUOX2	50506	broad.mit.edu	37	chr15	45387648	45387648	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgctcaccttcttacacagcAtttggctgcccaaggatgac	8	13	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr15:45387648A>C	uc010bea.2	-	31	4429	c.4226T>G	c.(4225-4227)ATG>AGG	p.M1409R	DUOX2_uc001zun.2_Missense_Mutation_p.M1409R	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1409	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CTTACACAGCATTTGGCTGCC	0.532													C	45387648	C	C	45387648	3	2	190	1	0	0	0	0	1	0	0	0	4801	217	8	5	436	5	DUOX2	15	45387648	Missense_Mutation	SNP	A	TCGA-27-1838-01A-01D-1494-08	3577337	45387648	57143744	87	13499											
ZNF263	10127	broad.mit.edu	37	chr16	3339694	3339694	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aactcaaacctaattaggcaCcagagaatacatgcagctga	7	10	1	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr16:3339694C>A	uc002cuq.2	+	6	1520	c.1188C>A	c.(1186-1188)CAC>CAA	p.H396Q	ZNF263_uc010uww.1_Missense_Mutation_p.H44Q|ZNF263_uc002cur.2_Missense_Mutation_p.H44Q	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	396	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						TAATTAGGCACCAGAGAATAC	0.478													A	3339694	A	A	3339694	3	1	190	1	0	0	0	0	1	0	0	0	17800	506	18	5	1210	5	ZNF263	16	3339694	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08		3339694	87015059	88	13500											
ATF7IP2	80063	broad.mit.edu	37	chr16	10525310	10525310	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcacttgacactaataacaAcagtaagtatatacttatgc	4	8	1	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr16:10525310A>G	uc002czu.2	+	3	1060	c.833A>G	c.(832-834)AAC>AGC	p.N278S	ATF7IP2_uc002czv.2_Missense_Mutation_p.N278S|ATF7IP2_uc010uyo.1_RNA|ATF7IP2_uc010uyp.1_Intron|ATF7IP2_uc002czw.2_Missense_Mutation_p.N278S|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						ACTAATAACAACAGTAAGTAT	0.313													G	10525310	G	G	10525310	3	3	190	1	0	0	0	0	1	0	0	0	1088	43	2	4	835	4	ATF7IP2	16	10525310	Missense_Mutation	SNP	A	TCGA-27-1838-01A-01D-1494-08	7185616	10525310	79829443	89	13501											
AQP8	343	broad.mit.edu	37	chr16	25232824	25232824	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctggcagccatgctgatcGgaggcctcaacctggtgatg	13	13	1	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr16:25232824G>A	uc002doc.2	+	3	389	c.307G>A	c.(307-309)GGA>AGA	p.G103R		NM_001169	NP_001160	O94778	AQP8_HUMAN	aquaporin 8	103	Helical; (Potential).				cellular response to cAMP	integral to plasma membrane	water channel activity			upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(48;0.044)		CATGCTGATCGGAGGCCTCAA	0.627													A	25232824	A	A	25232824	3	1	190	1	0	0	0	0	1	0	0	0	832	1117	39	2	317	2	AQP8	16	25232824	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	14707514	25232824	65121929	90	13502											
TP53	7157	broad.mit.edu	37	chr17	7577114	7577114	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtctctcccaggacaggcaCaaacacgcacctcaaagctg	9	15	2	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr17:7577114C>T	uc002gim.2	-	8	1018	c.824G>A	c.(823-825)TGT>TAT	p.C275Y	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.C275Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C143Y|TP53_uc010cng.1_Missense_Mutation_p.C143Y|TP53_uc002gii.1_Missense_Mutation_p.C143Y|TP53_uc010cnh.1_Missense_Mutation_p.C275Y|TP53_uc010cni.1_Missense_Mutation_p.C275Y|TP53_uc002gij.2_Missense_Mutation_p.C275Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	275	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C275Y(44)|p.C275F(34)|p.C275G(7)|p.C275W(7)|p.0?(7)|p.C275R(6)|p.C275C(4)|p.C275fs*70(2)|p.C275fs*31(2)|p.?(2)|p.C275S(2)|p.R273_C275delRVC(1)|p.C275_A276ins10(1)|p.V274_P278del(1)|p.C275*(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.C275fs*67(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.A276fs*29(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGACAGGCACAAACACGCAC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577114	T	T	7577114	3	4	190	1	0	0	0	0	1	0	0	0	16378	478	17	3	462	3	TP53	17	7577114	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08		7577114	73618096	91	13503											
TP53	7157	broad.mit.edu	37	chr17	7577610	7577610	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggtacagtcagagccaaccTaggagataacacaggcccaa	10	11	1	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr17:7577610T>C	uc002gim.2	-	7	867	c.673_splice	c.e7-1	p.V225_splice	TP53_uc002gig.1_Splice_Site_p.V225_splice|TP53_uc002gih.2_Splice_Site_p.V225_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.V93_splice|TP53_uc010cng.1_Splice_Site_p.V93_splice|TP53_uc002gii.1_Splice_Site_p.V93_splice|TP53_uc010cnh.1_Splice_Site_p.V225_splice|TP53_uc010cni.1_Splice_Site_p.V225_splice|TP53_uc002gij.2_Splice_Site_p.V225_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(22)|p.0?(7)|p.V225fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGAGCCAACCTAGGAGATAAC	0.483		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7577610	C	C	7577610	5	2	190	1	0	0	0	0	0	0	1	0	16378	1536	53	4	619	4	TP53	17	7577610	Splice_Site	SNP	T	TCGA-27-1838-01A-01D-1494-08	496	7577610	73617600	92	13504											
CCDC42	146849	broad.mit.edu	37	chr17	8644917	8644917	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgcgcttggtcagctcctGcatgtgctggcacttgagtt	12	11	1	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr17:8644917G>A	uc002gln.2	-	4	594	c.367C>T	c.(367-369)CAG>TAG	p.Q123*	CCDC42_uc002glo.2_Nonsense_Mutation_p.Q123*	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	123	Potential.									ovary(1)	1						GTCAGCTCCTGCATGTGCTGG	0.602													A	8644917	A	A	8644917	4	1	190	1	0	0	0	0	0	1	0	0	2814	1328	46	3	599	3	CCDC42	17	8644917	Nonsense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	1067307	8644917	72550293	93	13505											
DNAH9	1770	broad.mit.edu	37	chr17	11568211	11568211	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctggaagacttatgttaactCtattgacaatttgttgctga	8	6	1	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr17:11568211C>A	uc002gne.2	+	15	2725	c.2657C>A	c.(2656-2658)TCT>TAT	p.S886Y	DNAH9_uc010coo.2_Missense_Mutation_p.S180Y	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	886	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TATGTTAACTCTATTGACAAT	0.383													A	11568211	A	A	11568211	3	1	190	1	0	0	0	0	1	0	0	0	4608	913	32	5	2715	5	DNAH9	17	11568211	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	2923294	11568211	69626999	94	13506											
DHX58	79132	broad.mit.edu	37	chr17	40263362	40263362	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggggctggtcagtgccatctGcagaagctctgctgtgcaga	15	10	3	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr17:40263362G>T	uc002hyw.3	-	4	545	c.322C>A	c.(322-324)CAG>AAG	p.Q108K	DHX58_uc002hyv.3_Intron|DHX58_uc010wgf.1_Missense_Mutation_p.Q101K	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	108	Helicase ATP-binding.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGTGCCATCTGCAGAAGCTCT	0.622													T	40263362	T	T	40263362	3	4	190	1	0	0	0	0	1	0	0	0	4514	1328	46	5	1758	5	DHX58	17	40263362	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	28695151	40263362	40931848	95	13507											
HEATR6	63897	broad.mit.edu	37	chr17	58137429	58137429	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttgagccttccaagatggcaGataaaacttgcagagcacag	10	9	0	4			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr17:58137429G>C	uc002iyk.1	-	10	1462	c.1445C>G	c.(1444-1446)TCT>TGT	p.S482C	HEATR6_uc010ddk.1_Missense_Mutation_p.S21C|HEATR6_uc010wos.1_Missense_Mutation_p.S314C	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	482	HEAT 2.						binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			CAAGATGGCAGATAAAACTTG	0.433													C	58137429	C	C	58137429	3	2	190	1	0	0	0	0	1	0	0	0	7033	942	33	5	2144	5	HEATR6	17	58137429	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	17874067	58137429	23057781	96	13508											
KCNJ16	3773	broad.mit.edu	37	chr17	68128948	68128948	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcatttaaagacctcaaattAgtcaacgaccaaatcatcct	4	11	3	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr17:68128948A>T	uc002jin.2	+	5	1206	c.720A>T	c.(718-720)TTA>TTT	p.L240F	KCNJ16_uc002jio.2_Missense_Mutation_p.L240F|KCNJ16_uc002jip.2_Missense_Mutation_p.L240F|KCNJ16_uc002jiq.2_Missense_Mutation_p.L272F	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	240	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					ACCTCAAATTAGTCAACGACC	0.483													T	68128948	T	T	68128948	3	4	190	1	0	0	0	0	1	0	0	0	8050	417	15	5	722	5	KCNJ16	17	68128948	Missense_Mutation	SNP	A	TCGA-27-1838-01A-01D-1494-08	9991519	68128948	13066262	97	13509											
SMCHD1	23347	broad.mit.edu	37	chr18	2688412	2688412	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatcattcaggatatgttcGtccagtaccagtgccacgca	9	11	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr18:2688412G>A	uc002klm.3	+	6	848	c.659G>A	c.(658-660)CGT>CAT	p.R220H		NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	220					chromosome organization		ATP binding				0						GGATATGTTCGTCCAGTACCA	0.368													A	2688412	A	A	2688412	3	1	190	1	0	0	0	0	1	0	0	0	14788	1145	40	1	681	1	SMCHD1	18	2688412	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08		2688412	75388836	98	13510											
DSG4	147409	broad.mit.edu	37	chr18	28993484	28993484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accttcccataggccaaaccGttggctccacatcccccatg	6	18	0	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr18:28993484G>A	uc002kwq.2	+	16	3184	c.3049G>A	c.(3049-3051)GTT>ATT	p.V1017I	DSG4_uc002kwr.2_Missense_Mutation_p.V1036I	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	1017	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGGCCAAACCGTTGGCTCCAC	0.453													A	28993484	A	A	28993484	3	1	190	1	0	0	0	0	1	0	0	0	4779	1145	40	1	3232	1	DSG4	18	28993484	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	26305072	28993484	49083764	99	13511											
CDH19	28513	broad.mit.edu	37	chr18	64218401	64218401	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acacttgttgttccagacaaCgctcctggctgaccaatcat	7	13	1	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr18:64218401C>T	uc002lkc.1	-	5	843	c.705G>A	c.(703-705)GCG>GCA	p.A235A	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Silent_p.A235A|CDH19_uc002lkd.2_Silent_p.A235A	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	235	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TTCCAGACAACGCTCCTGGCT	0.328													T	64218401	T	T	64218401	2	4	190	1	0	0	0	0	0	0	0	1	3104	523	19	1		1	CDH19	18	64218401	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08	35224917	64218401	13858847	100	13512											
FBN3	84467	broad.mit.edu	37	chr19	8191373	8191373	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gatctcgcagcgttcgcaggGgctcccccaggctgccccga	13	17	1	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr19:8191373G>C	uc002mjf.2	-	19	2554	c.2533C>G	c.(2533-2535)CCC>GCC	p.P845A		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	845	TB 4.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CGTTCGCAGGGGCTCCCCCAG	0.667													C	8191373	C	C	8191373	3	2	190	1	0	0	0	0	1	0	0	0	5704	1232	43	5	6076	5	FBN3	19	8191373	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08		8191373	50937610	101	13513											
TNPO2	30000	broad.mit.edu	37	chr19	12825902	12825902	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggatgagcctgtcaatccGcacttccagaagcatcacca	10	13	2	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr19:12825902G>A	uc002muo.2	-	8	915	c.730C>T	c.(730-732)CGG>TGG	p.R244W	TNPO2_uc002mup.2_Missense_Mutation_p.R336W|TNPO2_uc002muq.2_Missense_Mutation_p.R244W|TNPO2_uc002mur.2_Missense_Mutation_p.R244W	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	244	HEAT 3.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						CTGTCAATCCGCACTTCCAGA	0.632													A	12825902	A	A	12825902	3	1	190	1	0	0	0	0	1	0	0	0	16333	1086	38	1	2031	1	TNPO2	19	12825902	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	4634529	12825902	46303081	102	13514											
ZNF17	7565	broad.mit.edu	37	chr19	57931383	57931383	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acagtgggtggaagccacacAgggacactcatggtgtggag	16	8	1	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr19:57931383A>G	uc002qoo.1	+	3	754	c.523A>G	c.(523-525)AGG>GGG	p.R175G	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Missense_Mutation_p.R177G	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		GAAGCCACACAGGGACACTCA	0.488													G	57931383	G	G	57931383	3	3	190	1	0	0	0	0	1	0	0	0	17740	179	7	4	533	4	ZNF17	19	57931383	Missense_Mutation	SNP	A	TCGA-27-1838-01A-01D-1494-08	45105481	57931383	1197600	103	13515											
ANGPT4	51378	broad.mit.edu	37	chr20	870858	870858	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tcagtcaccctctgttacctGagcctccatgtcggtcagct	8	15	4	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr20:870858G>A	uc002wei.2	-	2	566	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	ANGPT4_uc010zpn.1_Nonsense_Mutation_p.Q149*	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	155	Potential.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						TCTGTTACCTGAGCCTCCATG	0.607													A	870858	A	A	870858	4	1	190	1	0	0	0	0	0	1	0	0	612	1299	45	3	1080	3	ANGPT4	20	870858	Nonsense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08		870858	62154662	104	13516											
SIRPA	140885	broad.mit.edu	37	chr20	1915375	1915375	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttttaggttgcatgagcccgAgaagaatgccagagaaataa	11	6	0	4			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr20:1915375A>T	uc002wfq.2	+	8	1601	c.1241A>T	c.(1240-1242)GAG>GTG	p.E414V	SIRPA_uc010zps.1_Missense_Mutation_p.E394V|SIRPA_uc002wfr.2_Missense_Mutation_p.E414V|SIRPA_uc002wfs.2_Missense_Mutation_p.E414V|SIRPA_uc002wft.2_Missense_Mutation_p.E414V	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	414	Cytoplasmic (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		CATGAGCCCGAGAAGAATGCC	0.338													T	1915375	T	T	1915375	3	4	190	1	0	0	0	0	1	0	0	0	14332	304	11	5	1267	5	SIRPA	20	1915375	Missense_Mutation	SNP	A	TCGA-27-1838-01A-01D-1494-08	1044517	1915375	61110145	105	13517											
PTPRT	11122	broad.mit.edu	37	chr20	41385120	41385120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctttcacgatcagctccgCgtagttggacacaccagacc	8	15	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chr20:41385120C>T	uc002xkg.2	-	6	1025	c.841G>A	c.(841-843)GCG>ACG	p.A281T	PTPRT_uc010ggj.2_Missense_Mutation_p.A281T	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	281	Extracellular (Potential).|Ig-like C2-type.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATCAGCTCCGCGTAGTTGGAC	0.567													T	41385120	T	T	41385120	3	4	190	1	0	0	0	0	1	0	0	0	12812	768	27	1	3649	1	PTPRT	20	41385120	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	39469745	41385120	21640400	106	13518											
MXRA5	25878	broad.mit.edu	37	chrX	3235331	3235331	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctgcaccgtcctgcgcgCggagcctaccaggttggcgg	15	15	0	0			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:3235331C>T	uc004crg.3	-	6	6548	c.6391G>A	c.(6391-6393)GCG>ACG	p.A2131T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2131	Ig-like C2-type 5.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTCCTGCGCGCGGAGCCTACC	0.662													T	3235331	T	T	3235331	3	4	190	1	0	0	0	0	1	0	0	0	10003	768	27	1	2103	1	MXRA5	23	3235331	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08		3235331	152035229	107	13519											
MAGEB6	158809	broad.mit.edu	37	chrX	26212996	26212996	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagataagtacgtggtttacCggcaggtgtgcaacagtgat	13	6	0	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:26212996C>T	uc004dbr.2	+	2	1182	c.1033C>T	c.(1033-1035)CGG>TGG	p.R345W	MAGEB6_uc010ngc.1_Missense_Mutation_p.R125W	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	345	MAGE.									ovary(3)	3						CGTGGTTTACCGGCAGGTGTG	0.498													T	26212996	T	T	26212996	3	4	190	1	0	0	0	0	1	0	0	0	9179	643	23	2	1035	2	MAGEB6	23	26212996	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	22977665	26212996	129057564	108	13520											
USP9X	8239	broad.mit.edu	37	chrX	41075579	41075579	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgaagaaatgaaaaaccagtGttttggtggagagtacatgg	13	4	0	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:41075579G>C	uc004dfb.2	+	35	6392	c.5759G>C	c.(5758-5760)TGT>TCT	p.C1920S	USP9X_uc004dfc.2_Missense_Mutation_p.C1920S	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1920					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						AAAAACCAGTGTTTTGGTGGA	0.388													C	41075579	C	C	41075579	3	2	190	1	0	0	0	0	1	0	0	0	17087	1377	48	5	5893	5	USP9X	23	41075579	Missense_Mutation	SNP	G	TCGA-27-1838-01A-01D-1494-08	14862583	41075579	114194981	109	13521											
SLC9A7	84679	broad.mit.edu	37	chrX	46491045	46491047	+	In_Frame_Del	DEL	GTT	-	-													tgtaagacttgaaagctgtcGttgttgggtggtgggtcttg							TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:46491045_46491047delGTT	uc004dgu.1	-	14	1719_1721	c.1711_1713delAAC	c.(1711-1713)AACdel	p.N571del		NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	571					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						GAAAGCTGTCGTTGTTGGGTGGT	0.384													-	46491047	-	-	46491045	7	5	190	1	0	1	0	1	0	0	0	0	14719	1136	40	0	480	0	SLC9A7	23	46491045	In_Frame_Del	DEL	GTT	TCGA-27-1838-01A-01D-1494-08	5415466	46491045	108779515	110	13522											
SSX7	280658	broad.mit.edu	37	chrX	52677324	52677324	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcttaccggatgtcttgttAatcttctcagaggtacttgg	9	9	4	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:52677324A>G	uc004dqx.1	-	6	612	c.453T>C	c.(451-453)ATT>ATC	p.I151I		NM_173358	NP_775494	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			skin(1)	1	Ovarian(276;0.236)					ATGTCTTGTTAATCTTCTCAG	0.512													G	52677324	G	G	52677324	2	3	190	1	0	0	0	0	0	0	0	1	15208	358	13	4		4	SSX7	23	52677324	Silent	SNP	A	TCGA-27-1838-01A-01D-1494-08	6186279	52677324	102593236	111	13523											
KIAA2022	340533	broad.mit.edu	37	chrX	73963402	73963402	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagttgaattgggcatcttcCtgcatcaaaagagtagtctt	9	7	3	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:73963402C>T	uc004eby.2	-	3	1607	c.990G>A	c.(988-990)CAG>CAA	p.Q330Q		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	330					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GGGCATCTTCCTGCATCAAAA	0.448													T	73963402	T	T	73963402	2	4	190	1	0	0	0	0	0	0	0	1	8269	680	24	3		3	KIAA2022	23	73963402	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08	21286078	73963402	81307158	112	13524											
PAK3	5063	broad.mit.edu	37	chrX	110406206	110406208	+	In_Frame_Del	DEL	GAA	-	-													ctgaagaagaagatgaagagGaagaagaagaagaagatgaa							TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:110406206_110406208delGAA	uc004epa.2	+	6	604_606	c.577_579delGAA	c.(577-579)GAAdel	p.E197del	PAK3_uc010npt.1_In_Frame_Del_p.E182del|PAK3_uc010npu.1_In_Frame_Del_p.E182del|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_In_Frame_Del_p.E182del|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_In_Frame_Del_p.E218del|PAK3_uc010npw.1_In_Frame_Del_p.E203del	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	197	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						agatgaagaggaagaagaagaag	0.325										TSP Lung(19;0.15)			-	110406208	-	-	110406206	7	5	190	1	0	1	0	1	0	0	0	0	11402	1175	41	0	666	0	PAK3	23	110406206	In_Frame_Del	DEL	GAA	TCGA-27-1838-01A-01D-1494-08	36442804	110406206	44864354	113	13525											
KIAA1210	57481	broad.mit.edu	37	chrX	118220581	118220581	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctctgttgcttatctgcaaCgtaagatattttggtgaggt	11	6	2	2			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:118220581C>T	uc004era.3	-	11	4612	c.4612G>A	c.(4612-4614)GTT>ATT	p.V1538I		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1538										ovary(4)|skin(1)	5						TTATCTGCAACGTAAGATATT	0.507													T	118220581	T	T	118220581	3	4	190	1	0	0	0	0	1	0	0	0	8214	536	19	1	533	1	KIAA1210	23	118220581	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	7814375	118220581	37049979	114	13526											
DCAF12L1	139170	broad.mit.edu	37	chrX	125686304	125686304	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgcgaacaccttgttgacCgtgcccagctccagttggcg	12	14	0	1	rs141018282		TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:125686304C>T	uc004eul.2	-	1	539	c.288G>A	c.(286-288)ACG>ACA	p.T96T		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	96										skin(3)|ovary(1)	4						CCTTGTTGACCGTGCCCAGCT	0.657													T	125686304	T	T	125686304	2	4	190	1	0	0	0	0	0	0	0	1	4264	639	23	2		2	DCAF12L1	23	125686304	Silent	SNP	C	TCGA-27-1838-01A-01D-1494-08	7465723	125686304	29584256	115	13527											
USP26	83844	broad.mit.edu	37	chrX	132160788	132160788	+	Frame_Shift_Del	DEL	A	-	-													tactcaagctcttctgctccAaaaaaaagatcaaaagtaga							TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:132160788delA	uc010nrm.1	-	6	1931	c.1461delT	c.(1459-1461)TTTfs	p.F487fs	USP26_uc011mvf.1_Frame_Shift_Del_p.F487fs	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	487					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity	p.G488fs*6(2)|p.F487fs*7(1)		lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					CTTCTGCTCCAAAAAAAAGAT	0.383													-	132160788	-	-	132160788	7	5	190	1	0	1	0	1	0	0	0	0	17054	127	5	0	1283	0	USP26	23	132160788	Frame_Shift_Del	DEL	A	TCGA-27-1838-01A-01D-1494-08	6474484	132160788	23109772	116	13528											
MAGEA10	4109	broad.mit.edu	37	chrX	151303934	151303934	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggaggaagaggaggaggaGggaaaagaggatggaaaaga	21	0	0	3			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:151303934G>A	uc004ffk.2	-	5	567	c.159C>T	c.(157-159)CCC>CCT	p.P53P	MAGEA10_uc004ffl.2_Silent_p.P53P	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	53											0	Acute lymphoblastic leukemia(192;6.56e-05)					aggaggaggagggaaaagagg	0.418													A	151303934	A	A	151303934	2	1	190	1	0	0	0	0	0	0	0	1	9164	987	35	3		3	MAGEA10	23	151303934	Silent	SNP	G	TCGA-27-1838-01A-01D-1494-08	19143146	151303934	3966626	117	13529											
RENBP	5973	broad.mit.edu	37	chrX	153209567	153209567	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ccacacatacttgaggtcatCatacacccgcccctcgcggc	7	18	2	1			TCGA-27-1838-01A-01D-1494-08	TCGA-27-1838-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	881af1d2-3fbc-44dd-8362-e6c386345cf6	d3e925a1-2c02-4722-a862-78d17ef59052	g.chrX:153209567C>A	uc004fjo.1	-	3	348	c.178G>T	c.(178-180)GAT>TAT	p.D60Y	RENBP_uc011mzh.1_Missense_Mutation_p.D60Y	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	60					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	TTGAGGTCATCATACACCCGC	0.632													A	153209567	A	A	153209567	3	1	190	1	0	0	0	0	1	0	0	0	13225	826	29	5	1141	5	RENBP	23	153209567	Missense_Mutation	SNP	C	TCGA-27-1838-01A-01D-1494-08	1905633	153209567	2060993	118	13530											
LOC649330	649330	broad.mit.edu	37	chr1	12907821	12907821	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gccatagtccaagtcaaaagAggagccgtacatctccgctg	10	12	2	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr1:12907821A>T	uc009vno.2	-	1	417	c.322T>A	c.(322-324)TCT>ACT	p.S108T	HNRNPCL1_uc010obf.1_Missense_Mutation_p.S108T	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	108							nucleic acid binding|nucleotide binding				0						AAGTCAAAAGAGGAGCCGTAC	0.493													T	12907821	T	T	12907821	3	4	191	1	0	0	0	0	1	0	0	0	8885	304	11	5	563	5	LOC649330	1	12907821	Missense_Mutation	SNP	A	TCGA-27-2518-01A-01D-1494-08		12907821	236342800	1	13531											
HPCAL4	51440	broad.mit.edu	37	chr1	40150150	40150150	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgaaactcctccaggttgagGatgccgctggggcagtcctt	13	11	0	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr1:40150150G>A	uc001cdr.2	-	2	246	c.126C>T	c.(124-126)ATC>ATT	p.I42I	HPCAL4_uc010oix.1_Silent_p.I42I	NM_016257	NP_057341	Q9UM19	HPCL4_HUMAN	hippocalcin-like protein 4	42	EF-hand 1.				central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CCAGGTTGAGGATGCCGCTGG	0.627													A	40150150	A	A	40150150	2	1	191	1	0	0	0	0	0	0	0	1	7331	1164	41	3		3	HPCAL4	1	40150150	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08	27242329	40150150	209100471	2	13532											
ELTD1	64123	broad.mit.edu	37	chr1	79383365	79383365	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taaaactccaaataaagttgTtttcggtgctaagccaacat	6	8	0	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr1:79383365T>C	uc001diq.3	-	12	1859	c.1703A>G	c.(1702-1704)AAC>AGC	p.N568S		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	568	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		AATAAAGTTGTTTTCGGTGCT	0.279													C	79383365	C	C	79383365	3	2	191	1	0	0	0	0	1	0	0	0	5084	1725	60	4	385	4	ELTD1	1	79383365	Missense_Mutation	SNP	T	TCGA-27-2518-01A-01D-1494-08	39233215	79383365	169867256	3	13533											
SLC26A9	115019	broad.mit.edu	37	chr1	205890886	205890886	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaaggtgatataggacacGctggtgccgttagccggggt	16	8	0	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr1:205890886G>A	uc001hdq.2	-	17	1977	c.1863C>T	c.(1861-1863)AGC>AGT	p.S621S	SLC26A9_uc001hdo.2_Silent_p.S289S|SLC26A9_uc001hdp.2_Silent_p.S621S	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	621	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TATAGGACACGCTGGTGCCGT	0.642													A	205890886	A	A	205890886	2	1	191	1	0	0	0	0	0	0	0	1	14524	1078	38	1		1	SLC26A9	1	205890886	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08	126507521	205890886	43359735	4	13534											
WDR64	128025	broad.mit.edu	37	chr1	241959665	241959665	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagggaggtcatgttcaacGtgaaaaagtaagttagtact	12	4	2	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr1:241959665G>A	uc001hzf.1	+	16	1967	c.1814G>A	c.(1813-1815)CGT>CAT	p.R605H	WDR64_uc001hzg.1_Missense_Mutation_p.R518H	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	1052										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CATGTTCAACGTGAAAAAGTA	0.378													A	241959665	A	A	241959665	3	1	191	1	0	0	0	0	1	0	0	0	17312	1145	40	1	3257	1	WDR64	1	241959665	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08	36068779	241959665	7290956	5	13535											
KLF11	8462	broad.mit.edu	37	chr2	10186413	10186413	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tatgagctcctggggtcaaaGatcccagaaaggtgacctgt	12	9	1	4			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr2:10186413G>T	uc002raf.1	+	2	341	c.179G>T	c.(178-180)AGA>ATA	p.R60I	KLF11_uc010yjc.1_Missense_Mutation_p.R43I	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	60					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		TGGGGTCAAAGATCCCAGAAA	0.537													T	10186413	T	T	10186413	3	4	191	1	0	0	0	0	1	0	0	0	8339	942	33	5	185	5	KLF11	2	10186413	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08		10186413	233012960	6	13536											
LAPTM4A	9741	broad.mit.edu	37	chr2	20240757	20240757	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cacagtcagcaaaattgccaTcaataggtttactacctgga	7	10	2	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr2:20240757T>A	uc002rdm.2	-	2	635	c.127A>T	c.(127-129)ATG>TTG	p.M43L	LAPTM4A_uc002rdn.2_Missense_Mutation_p.M1L|LAPTM4A_uc010yjx.1_Missense_Mutation_p.M43L	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	43	Helical; (Potential).				transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAAATTGCCATCAATAGGTTT	0.378													A	20240757	A	A	20240757	3	1	191	1	0	0	0	0	1	0	0	0	8624	1435	50	5	598	5	LAPTM4A	2	20240757	Missense_Mutation	SNP	T	TCGA-27-2518-01A-01D-1494-08	10054344	20240757	222958616	7	13537											
PROM2	150696	broad.mit.edu	37	chr2	95947041	95947041	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccctcatcctcctggtgttCgccaccttcctggtgggtgg	11	16	1	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr2:95947041C>T	uc002suh.1	+	12	1612	c.1479C>T	c.(1477-1479)TTC>TTT	p.F493F	PROM2_uc002sui.2_Silent_p.F493F|PROM2_uc002suj.2_Silent_p.F147F|PROM2_uc002suk.2_Silent_p.F493F|PROM2_uc002sul.2_Silent_p.F19F|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	493	Helical; (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						TCCTGGTGTTCGCCACCTTCC	0.642													T	95947041	T	T	95947041	2	4	191	1	0	0	0	0	0	0	0	1	12556	883	31	2		2	PROM2	2	95947041	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08	75706284	95947041	147252332	8	13538											
DPP10	57628	broad.mit.edu	37	chr2	116534868	116534868	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tggcatacgatgaaactactCaaaaaatgtgagtgttttca	8	6	2	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr2:116534868C>A	uc002tla.1	+	14	1763	c.1306C>A	c.(1306-1308)CAA>AAA	p.Q436K	DPP10_uc002tlb.1_Missense_Mutation_p.Q386K|DPP10_uc002tlc.1_Missense_Mutation_p.Q432K|DPP10_uc002tle.2_Missense_Mutation_p.Q440K|DPP10_uc002tlf.1_Missense_Mutation_p.Q429K	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	436	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TGAAACTACTCAAAAAATGTG	0.378													A	116534868	A	A	116534868	3	1	191	1	0	0	0	0	1	0	0	0	4727	827	29	5	1531	5	DPP10	2	116534868	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	20587827	116534868	126664505	9	13539											
SCN2A	6326	broad.mit.edu	37	chr2	166179852	166179852	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccgcacagacatggagaaCggcgccacagcaatgtcagc	12	13	1	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr2:166179852C>T	uc002udc.2	+	12	2148	c.1858C>T	c.(1858-1860)CGG>TGG	p.R620W	SCN2A_uc002udd.2_Missense_Mutation_p.R620W|SCN2A_uc002ude.2_Missense_Mutation_p.R620W	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	620					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ACATGGAGAACGGCGCCACAG	0.562													T	166179852	T	T	166179852	3	4	191	1	0	0	0	0	1	0	0	0	13916	527	19	1	1996	1	SCN2A	2	166179852	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	49644984	166179852	77019521	10	13540											
SPEG	10290	broad.mit.edu	37	chr2	220329174	220329174	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgagaaaccgccagcccGtgcgcccagaccagcggcgc	14	17	0	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr2:220329174G>A	uc010fwg.2	+	9	2725	c.2725G>A	c.(2725-2727)GTG>ATG	p.V909M	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Missense_Mutation_p.V117M|SPEG_uc002vln.1_Missense_Mutation_p.V117M|SPEG_uc002vlp.1_Missense_Mutation_p.V117M|SPEG_uc002vlq.2_Missense_Mutation_p.V60M	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	909	Ig-like 3.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCGCCAGCCCGTGCGCCCAGA	0.662													A	220329174	A	A	220329174	3	1	191	1	0	0	0	0	1	0	0	0	15035	1145	40	1	2759	1	SPEG	2	220329174	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08	54149322	220329174	22870199	11	13541											
SPHKAP	80309	broad.mit.edu	37	chr2	228856023	228856023	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgactgtcctttaagaatctTcttttcttctactaattcac	3	10	5	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr2:228856023T>A	uc002vpq.2	-	10	4788	c.4741A>T	c.(4741-4743)AAG>TAG	p.K1581*	SPHKAP_uc002vpp.2_Nonsense_Mutation_p.K1552*|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1581						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTAAGAATCTTCTTTTCTTCT	0.403													A	228856023	A	A	228856023	4	1	191	1	0	0	0	0	0	1	0	0	15047	1792	62	5	373	5	SPHKAP	2	228856023	Nonsense_Mutation	SNP	T	TCGA-27-2518-01A-01D-1494-08	8526849	228856023	14343350	12	13542											
IL5RA	3568	broad.mit.edu	37	chr3	3139660	3139660	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgccctttgctgaggataaaAgtcctgggaaaccagcatgc	11	11	0	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr3:3139660A>C	uc011ask.1	-	8	1247	c.603T>G	c.(601-603)ACT>ACG	p.T201T	IL5RA_uc010hbq.2_Silent_p.T201T|IL5RA_uc010hbr.2_Intron|IL5RA_uc010hbs.2_Silent_p.T201T|IL5RA_uc011asl.1_Silent_p.T201T|IL5RA_uc011asm.1_Silent_p.T201T|IL5RA_uc010hbt.2_Silent_p.T201T|IL5RA_uc011asn.1_Silent_p.T201T|IL5RA_uc010hbu.2_Silent_p.T201T	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	201	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		TGAGGATAAAAGTCCTGGGAA	0.493													C	3139660	C	C	3139660	2	2	191	1	0	0	0	0	0	0	0	1	7700	59	3	5		5	IL5RA	3	3139660	Silent	SNP	A	TCGA-27-2518-01A-01D-1494-08		3139660	194882770	13	13543											
FAM19A1	407738	broad.mit.edu	37	chr3	68466552	68466552	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctggaacaacaagaaacCggccttcttgcgtcgatggt	12	10	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr3:68466552C>T	uc003dnd.2	+	3	457	c.241C>T	c.(241-243)CGG>TGG	p.R81W	FAM19A1_uc003dne.2_Missense_Mutation_p.R81W|FAM19A1_uc003dng.2_Missense_Mutation_p.R81W	NM_213609	NP_998774	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine	81						endoplasmic reticulum|extracellular region				ovary(1)	1		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		AACAAGAAACCGGCCTTCTTG	0.418													T	68466552	T	T	68466552	3	4	191	1	0	0	0	0	1	0	0	0	5531	643	23	2	247	2	FAM19A1	3	68466552	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	65326892	68466552	129555878	14	13544											
HPS3	84343	broad.mit.edu	37	chr3	148868422	148868422	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcactgtgcggtgcagtgcGgcggcagctcgtgaggagga	18	9	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr3:148868422G>A	uc003ewu.1	+	6	1340	c.1200G>A	c.(1198-1200)GCG>GCA	p.A400A	HPS3_uc003ewt.1_Silent_p.A400A|HPS3_uc011bnq.1_Silent_p.A235A	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	400						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GGTGCAGTGCGGCGGCAGCTC	0.532									Hermansky-Pudlak_syndrome				A	148868422	A	A	148868422	2	1	191	1	0	0	0	0	0	0	0	1	7340	1103	39	2		2	HPS3	3	148868422	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08	80401870	148868422	49154008	15	13545											
CP	1356	broad.mit.edu	37	chr3	148925268	148925268	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgtcaatacggtagttcttGttagtcagtgcttgcccgtg	12	8	3	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr3:148925268G>T	uc003ewy.3	-	5	1171	c.918C>A	c.(916-918)AAC>AAA	p.N306K	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Missense_Mutation_p.N87K|CP_uc003ewz.2_Missense_Mutation_p.N306K|CP_uc010hvf.1_Missense_Mutation_p.N32K	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	306	F5/8 type A 1.|Plastocyanin-like 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	GGTAGTTCTTGTTAGTCAGTG	0.458													T	148925268	T	T	148925268	3	4	191	1	0	0	0	0	1	0	0	0	3787	1368	48	5	2339	5	CP	3	148925268	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08	56846	148925268	49097162	16	13546											
SAMD7	344658	broad.mit.edu	37	chr3	169654200	169654200	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gcatcttcgaggcactatggGattaaagctagggccggcac	13	10	1	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr3:169654200G>C	uc003fgd.2	+	8	1382	c.1115G>C	c.(1114-1116)GGA>GCA	p.G372A	SAMD7_uc003fge.2_Missense_Mutation_p.G372A|SAMD7_uc011bpo.1_Missense_Mutation_p.G273A	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	372	SAM.									skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GGCACTATGGGATTAAAGCTA	0.343													C	169654200	C	C	169654200	3	2	191	1	0	0	0	0	1	0	0	0	13824	1174	41	5	1137	5	SAMD7	3	169654200	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08	20728932	169654200	28368230	17	13547											
PCDHB12	56124	broad.mit.edu	37	chr5	140589502	140589502	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attcaggtgatggatgtaaaCgacaacgctcctgaaatcac	9	9	2	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr5:140589502C>T	uc003liz.2	+	1	1212	c.1023C>T	c.(1021-1023)AAC>AAT	p.N341N	PCDHB12_uc011dak.1_Silent_p.N4N	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	341	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGATGTAAACGACAACGCTC	0.413													T	140589502	T	T	140589502	2	4	191	1	0	0	0	0	0	0	0	1	11537	535	19	1		1	PCDHB12	5	140589502	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08		140589502	40325758	18	13548											
GFPT2	9945	broad.mit.edu	37	chr5	179731784	179731784	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gccctcacctggcgggccgtGacttgctgcagggcgttctg	15	14	2	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr5:179731784G>A	uc003mlw.1	-	17	1928	c.1830C>T	c.(1828-1830)GTC>GTT	p.V610V		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	610	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	GGCGGGCCGTGACTTGCTGCA	0.592													A	179731784	A	A	179731784	2	1	191	1	0	0	0	0	0	0	0	1	6346	1277	45	3		3	GFPT2	5	179731784	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08	39142282	179731784	1183476	19	13549											
GFPT2	9945	broad.mit.edu	37	chr5	179731922	179731922	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atgccttctgagtgcatgtaGgttatctctttaattttctg	8	7	3	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr5:179731922G>C	uc003mlw.1	-	17	1790	c.1692C>G	c.(1690-1692)ACC>ACG	p.T564T		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	564	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	AGTGCATGTAGGTTATCTCTT	0.537													C	179731922	C	C	179731922	2	2	191	1	0	0	0	0	0	0	0	1	6346	987	35	5		5	GFPT2	5	179731922	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08	138	179731922	1183338	20	13550											
VARS2	57176	broad.mit.edu	37	chr6	30883807	30883807	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggtccctggttcagatcatGcaggaattgctacacaagta	11	9	2	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr6:30883807G>T	uc003nsc.1	+	5	1188	c.556G>T	c.(556-558)GCA>TCA	p.A186S	VARS2_uc003nsd.2_Missense_Mutation_p.A186S|VARS2_uc011dmx.1_Missense_Mutation_p.A186S|VARS2_uc011dmy.1_Missense_Mutation_p.A46S|VARS2_uc011dmz.1_Missense_Mutation_p.A216S|VARS2_uc011dna.1_Missense_Mutation_p.A186S|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	186					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						TTCAGATCATGCAGGAATTGC	0.478													T	30883807	T	T	30883807	3	4	191	1	0	0	0	0	1	0	0	0	17121	1319	46	5	668	5	VARS2	6	30883807	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08		30883807	140231260	21	13551											
CLCN1	1180	broad.mit.edu	37	chr7	143047569	143047569	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gagcagacaaccctgcacaaGgtgagtcttttgctgactgc	11	11	1	3			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr7:143047569G>C	uc003wcr.1	+	21	2595	c.2508G>C	c.(2506-2508)AAG>AAC	p.K836N	CLCN1_uc011ktc.1_Missense_Mutation_p.K448N	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	836	CBS 2.|Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CCCTGCACAAGGTGAGTCTTT	0.567													C	143047569	C	C	143047569	3	2	191	1	0	0	0	0	1	0	0	0	3462	1014	35	5	2590	5	CLCN1	7	143047569	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08		143047569	16091094	22	13552											
WHSC1L1	54904	broad.mit.edu	37	chr8	38148069	38148069	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaacataagggaacactctGccctggtgtacccagtagta	9	11	2	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr8:38148069G>A	uc003xli.2	-	17	3560	c.3042C>T	c.(3040-3042)GGC>GGT	p.G1014G	WHSC1L1_uc011lbm.1_Silent_p.G1014G|WHSC1L1_uc010lwe.2_Silent_p.G965G	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	1014	PWWP 2.				cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			GGAACACTCTGCCCTGGTGTA	0.463			T	NUP98	AML								A	38148069	A	A	38148069	2	1	191	1	0	0	0	0	0	0	0	1	17360	1306	46	3		3	WHSC1L1	8	38148069	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08		38148069	108215953	23	13553											
JPH1	56704	broad.mit.edu	37	chr8	75171695	75171695	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctggcgagcggccagcgCggcctggtcggcggcatcgg	18	15	0	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr8:75171695C>T	uc003yae.2	-	3	1223	c.1183G>A	c.(1183-1185)GCG>ACG	p.A395T	JPH1_uc003yaf.2_Missense_Mutation_p.A395T|JPH1_uc003yag.1_Missense_Mutation_p.A259T	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	395	Ala-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GCGGCCAGCGCGGCCTGGTCG	0.597													T	75171695	T	T	75171695	3	4	191	1	0	0	0	0	1	0	0	0	7960	768	27	1	814	1	JPH1	8	75171695	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	37023626	75171695	71192327	24	13554											
RALYL	138046	broad.mit.edu	37	chr8	85774546	85774546	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taaaggttatttgattaccaCgggcgtgtgcctccacctcc	9	12	0	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr8:85774546C>T	uc003ycq.3	+	7	845	c.429C>T	c.(427-429)CAC>CAT	p.H143H	RALYL_uc003ycr.3_Silent_p.H143H|RALYL_uc003ycs.3_Silent_p.H143H|RALYL_uc010lzy.2_Silent_p.H132H|RALYL_uc003yct.3_Silent_p.H156H|RALYL_uc003ycu.3_Silent_p.H70H|RALYL_uc003ycv.3_Silent_p.H55H	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	143							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						TTGATTACCACGGGCGTGTGC	0.483													T	85774546	T	T	85774546	2	4	191	1	0	0	0	0	0	0	0	1	13020	535	19	1		1	RALYL	8	85774546	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08	10602851	85774546	60589476	25	13555											
CORO2A	7464	broad.mit.edu	37	chr9	100897128	100897128	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaagaggatgttggcggccGtggggtgccactccaccagg	17	10	0	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr9:100897128G>A	uc004ayl.2	-	4	694	c.428C>T	c.(427-429)ACG>ATG	p.T143M	CORO2A_uc004aym.2_Missense_Mutation_p.T143M	NM_003389	NP_003380	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	143	WD 2.				actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)				GTTGGCGGCCGTGGGGTGCCA	0.468													A	100897128	A	A	100897128	3	1	191	1	0	0	0	0	1	0	0	0	3756	1145	40	1	1185	1	CORO2A	9	100897128	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08		100897128	40316303	26	13556											
OR51B6	390058	broad.mit.edu	37	chr11	5373571	5373571	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcacaatgagctacatccaCttccttttcccaccttttat	2	14	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr11:5373571C>A	uc010qzb.1	+	1	834	c.834C>A	c.(832-834)CAC>CAA	p.H278Q	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTACATCCACTTCCTTTTCC	0.398													A	5373571	A	A	5373571	3	1	191	1	0	0	0	0	1	0	0	0	11092	564	20	5	836	5	OR51B6	11	5373571	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08		5373571	129632945	27	13557											
ADM	133	broad.mit.edu	37	chr11	10327296	10327296	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgggttcgctcgccttcCtaggcgctgacaccgctcgg	12	16	0	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr11:10327296C>T	uc001mik.1	+	1	666	c.49C>T	c.(49-51)CTA>TTA	p.L17L	ADM_uc001mil.1_Silent_p.L17L|ADM_uc001mim.1_5'UTR	NM_001124	NP_001115	P35318	ADML_HUMAN	adrenomedullin precursor	17					blood circulation|cAMP biosynthetic process|female pregnancy|negative regulation of vasoconstriction|progesterone biosynthetic process|response to wounding	cytoplasm|extracellular space|soluble fraction	hormone activity			central_nervous_system(1)	1				all cancers(16;3.51e-65)|Epithelial(150;1.52e-62)|BRCA - Breast invasive adenocarcinoma(625;0.0257)		GCTCGCCTTCCTAGGCGCTGA	0.612													T	10327296	T	T	10327296	2	4	191	1	0	0	0	0	0	0	0	1	321	680	24	3		3	ADM	11	10327296	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08	4953725	10327296	124679220	28	13558											
CHST1	8534	broad.mit.edu	37	chr11	45671304	45671304	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggttcttcagctcctcctcCgaggcggcgatcttgtagcc	12	14	3	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr11:45671304C>T	uc001mys.1	-	4	1841	c.1170G>A	c.(1168-1170)TCG>TCA	p.S390S		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	390	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GCTCCTCCTCCGAGGCGGCGA	0.692													T	45671304	T	T	45671304	2	4	191	1	0	0	0	0	0	0	0	1	3397	639	23	2		2	CHST1	11	45671304	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08	35344008	45671304	89335212	29	13559											
OR4P4	81300	broad.mit.edu	37	chr11	55406609	55406609	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgttcatttacattagacCggtcacaacattctcagaag	6	9	3	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr11:55406609C>T	uc010rij.1	+	1	776	c.776C>T	c.(775-777)CCG>CTG	p.P259L		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TACATTAGACCGGTCACAACA	0.418													T	55406609	T	T	55406609	3	4	191	1	0	0	0	0	1	0	0	0	11080	652	23	2	778	2	OR4P4	11	55406609	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	9735305	55406609	79599907	30	13560											
OR5D13	390142	broad.mit.edu	37	chr11	55541762	55541762	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctgtgttttacacagtggcGattccaatgctgaacccatt	8	10	1	1	rs150209335	byFrequency	TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr11:55541762G>A	uc010ril.1	+	1	849	c.849G>A	c.(847-849)GCG>GCA	p.A283A		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				ACACAGTGGCGATTCCAATGC	0.363													A	55541762	A	A	55541762	2	1	191	1	0	0	0	0	0	0	0	1	11154	1045	37	2		2	OR5D13	11	55541762	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08	135153	55541762	79464754	31	13561											
OR6Q1	219952	broad.mit.edu	37	chr11	57798597	57798597	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtttggaccaccgactacGgagacccatgtatttcttcc	10	12	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr11:57798597G>A	uc010rjz.1	+	1	173	c.173G>A	c.(172-174)CGG>CAG	p.R58Q	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				CACCGACTACGGAGACCCATG	0.483													A	57798597	A	A	57798597	3	1	191	1	0	0	0	0	1	0	0	0	11208	1116	39	2	175	2	OR6Q1	11	57798597	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08	2256835	57798597	77207919	32	13562											
PLAC1L	219990	broad.mit.edu	37	chr11	59807922	59807922	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgctggaggtctgctcagaCgaaggtctccatggcgttag	15	9	3	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr11:59807922C>T	uc001nol.2	+	1	175	c.-10C>T	c.(-12--8)GACGA>GATGA			NM_173801	NP_776162	Q86WS3	PLACL_HUMAN	placenta-specific 1-like precursor							extracellular region				ovary(2)|skin(1)	3						TCTGCTCAGACGAAGGTCTCC	0.473													T	59807922	T	T	59807922	1	4	191	1	0	0	0	0	0	0	0	0	12013	551	19	1		1	PLAC1L	11	59807922	Translation_Start_Site	SNP	C	TCGA-27-2518-01A-01D-1494-08	2009325	59807922	75198594	33	13563											
SLC22A11	55867	broad.mit.edu	37	chr11	64329558	64329558	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatcttcgccccaacattcGtcatctactgcggcctgcgg	8	17	3	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr11:64329558G>A	uc001oai.2	+	3	954	c.580G>A	c.(580-582)GTC>ATC	p.V194I	SLC22A11_uc001oah.1_Missense_Mutation_p.R159H|SLC22A11_uc001oaj.2_Missense_Mutation_p.V194I|SLC22A11_uc009ypq.2_Missense_Mutation_p.V194I|SLC22A11_uc001oak.1_Missense_Mutation_p.V23I	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	194	Helical; (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	CCCAACATTCGTCATCTACTG	0.622											OREG0004030	type=REGULATORY REGION|Gene=SLC22A11|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	A	64329558	A	A	64329558	3	1	191	1	0	0	0	0	1	0	0	0	14442	1145	40	1	590	1	SLC22A11	11	64329558	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08	4521636	64329558	70676958	34	13564											
RAB38	23682	broad.mit.edu	37	chr11	87847172	87847172	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctactaggatttggcacagCcagagcagctggcaaccttg	11	12	0	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr11:87847172C>A	uc001pcj.1	-	3	667	c.620G>T	c.(619-621)GGC>GTC	p.G207V		NM_022337	NP_071732	P57729	RAB38_HUMAN	RAB38	207					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTTGGCACAGCCAGAGCAGCT	0.473													A	87847172	A	A	87847172	3	1	191	1	0	0	0	0	1	0	0	0	12928	739	26	5	19	5	RAB38	11	87847172	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	23517614	87847172	47159344	35	13565											
CCND2	894	broad.mit.edu	37	chr12	4409083	4409083	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctcctcaatagcctgcagCagtaccgtcaggaccaacgt	9	14	2	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr12:4409083C>T	uc001qmo.2	+	5	1083	c.778C>T	c.(778-780)CAG>TAG	p.Q260*		NM_001759	NP_001750	P30279	CCND2_HUMAN	cyclin D2	260					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|breast(1)|kidney(1)	3			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			TAGCCTGCAGCAGTACCGTCA	0.542			T	IGL@	NHL,CLL								T	4409083	T	T	4409083	4	4	191	1	0	0	0	0	0	1	0	0	2917	711	25	3	796	3	CCND2	12	4409083	Nonsense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08		4409083	129442812	36	13566											
PRPF40B	25766	broad.mit.edu	37	chr12	50030609	50030609	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgggagcgacgccaacaaCgcaagaatcgggaggccttc	13	12	0	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr12:50030609C>T	uc001rur.1	+	15	1535	c.1471C>T	c.(1471-1473)CGC>TGC	p.R491C	PRPF40B_uc001rup.1_Missense_Mutation_p.R513C|PRPF40B_uc001ruq.1_Missense_Mutation_p.R485C|PRPF40B_uc001rus.1_Missense_Mutation_p.R434C	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	491					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						ACGCCAACAACGCAAGAATCG	0.577											OREG0021797	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	50030609	T	T	50030609	3	4	191	1	0	0	0	0	1	0	0	0	12572	536	19	1	1529	1	PRPF40B	12	50030609	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	45621526	50030609	83821286	37	13567											
LEMD3	23592	broad.mit.edu	37	chr12	65564282	65564282	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccgctgactgctaaatcggcCggcggcaggctggagacttc	14	13	0	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr12:65564282C>A	uc001ssl.1	+	1	912	c.906C>A	c.(904-906)GCC>GCA	p.A302A	LEMD3_uc009zqo.1_Silent_p.A302A	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	302					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		CTAAATCGGCCGGCGGCAGGC	0.622													A	65564282	A	A	65564282	2	1	191	1	0	0	0	0	0	0	0	1	8721	639	23	5		5	LEMD3	12	65564282	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08	15533673	65564282	68287613	38	13568											
GLT1D1	144423	broad.mit.edu	37	chr12	129360521	129360521	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgcctttgactttgaaagccGatctgagattgcaaacctca	8	10	2	3			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr12:129360521G>A	uc010tbh.1	+	2	107	c.98G>A	c.(97-99)CGA>CAA	p.R33Q	GLT1D1_uc001uhx.1_Missense_Mutation_p.R44Q|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	44					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		TTTGAAAGCCGATCTGAGATT	0.488													A	129360521	A	A	129360521	3	1	191	1	0	0	0	0	1	0	0	0	6465	1058	37	2	137	2	GLT1D1	12	129360521	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08	63796239	129360521	4491374	39	13569											
F7	2155	broad.mit.edu	37	chr13	113771870	113771870	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtctccgcggcccactgtttCgacaaaatcaagaactggag	10	12	2	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr13:113771870C>T	uc001vsv.2	+	8	816	c.765C>T	c.(763-765)TTC>TTT	p.F255F	F7_uc001vsw.2_Silent_p.F233F|F7_uc010tjt.1_Silent_p.F186F	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	255	Peptidase S1.				anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	CCCACTGTTTCGACAAAATCA	0.622													T	113771870	T	T	113771870	2	4	191	1	0	0	0	0	0	0	0	1	5349	883	31	2		2	F7	13	113771870	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08		113771870	1398008	40	13570											
STYX	6815	broad.mit.edu	37	chr14	53217446	53217446	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taacccatataatatgcataCgacaaaatattgaagcaaac	4	8	0	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr14:53217446C>T	uc010tqy.1	+	5	252	c.190C>T	c.(190-192)CGA>TGA	p.R64*	STYX_uc001xaa.2_Nonsense_Mutation_p.R64*	NM_001130701	NP_001124173	Q8WUJ0	STYX_HUMAN	serine/threonine/tyrosine interacting protein	64					protein dephosphorylation|spermatogenesis	cytoplasm	protein tyrosine/serine/threonine phosphatase activity				0	Breast(41;0.176)					AATATGCATACGACAAAATAT	0.289													T	53217446	T	T	53217446	4	4	191	1	0	0	0	0	0	1	0	0	15359	528	19	1	204	1	STYX	14	53217446	Nonsense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08		53217446	54132094	41	13571											
KIAA1409	57578	broad.mit.edu	37	chr14	94109960	94109960	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagagacacttgggctagcCatcgtggtcctctccacatt	10	12	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr14:94109960C>T	uc001ybv.1	+	33	5696	c.5613C>T	c.(5611-5613)GCC>GCT	p.A1871A	KIAA1409_uc001ybs.1_Silent_p.A1849A	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2026						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTGGGCTAGCCATCGTGGTCC	0.498													T	94109960	T	T	94109960	2	4	191	1	0	0	0	0	0	0	0	1	8230	581	21	3		3	KIAA1409	14	94109960	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08	40892514	94109960	13239580	42	13572											
AHNAK2	113146	broad.mit.edu	37	chr14	105418809	105418809	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attttgaacttgctgtctttGgcagtcacgtccttgtcggc	10	10	2	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr14:105418809G>A	uc010axc.1	-	7	3099	c.2979C>T	c.(2977-2979)GCC>GCT	p.A993A	AHNAK2_uc001ypx.2_Silent_p.A893A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	993						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGCTGTCTTTGGCAGTCACGT	0.602													A	105418809	A	A	105418809	2	1	191	1	0	0	0	0	0	0	0	1	415	1335	47	3		3	AHNAK2	14	105418809	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08	11308849	105418809	1930731	43	13573											
SYNM	23336	broad.mit.edu	37	chr15	99671205	99671205	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaaggaggacacagaaggaCggtgcagtgggcgagaaggt	19	6	0	2			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr15:99671205C>T	uc002bup.2	+	6	2760	c.2640C>T	c.(2638-2640)GAC>GAT	p.D880D	SYNM_uc002buo.2_Silent_p.D880D|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	880	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						CACAGAAGGACGGTGCAGTGG	0.582													T	99671205	T	T	99671205	2	4	191	1	0	0	0	0	0	0	0	1	15452	535	19	1		1	SYNM	15	99671205	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08		99671205	2860187	44	13574											
GRIN2A	2903	broad.mit.edu	37	chr16	9857448	9857448	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaatttccctccagaagcCgttccctgtccttgaggctt	7	13	0	2	rs149745535		TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr16:9857448C>T	uc002czo.3	-	13	4501	c.3953G>A	c.(3952-3954)CGG>CAG	p.R1318Q	GRIN2A_uc010uym.1_Missense_Mutation_p.R1318Q|GRIN2A_uc010uyn.1_Intron|GRIN2A_uc002czr.3_Intron	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1318	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.R1318W(1)		skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTCCAGAAGCCGTTCCCTGTC	0.527													T	9857448	T	T	9857448	3	4	191	1	0	0	0	0	1	0	0	0	6779	652	23	2	445	2	GRIN2A	16	9857448	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08		9857448	80497305	45	13575											
DNAH3	55567	broad.mit.edu	37	chr16	21156695	21156695	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gtccatgacgtgcgttgcatCaagggcgggtaaaagctgtg	15	8	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr16:21156695C>G	uc010vbe.1	-	3	255	c.255G>C	c.(253-255)TTG>TTC	p.L85F	DNAH3_uc002die.2_Missense_Mutation_p.L56F	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	85	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TGCGTTGCATCAAGGGCGGGT	0.527													G	21156695	G	G	21156695	3	3	191	1	0	0	0	0	1	0	0	0	4603	825	29	5	12334	5	DNAH3	16	21156695	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	11299247	21156695	69198058	46	13576											
SEZ6L2	26470	broad.mit.edu	37	chr16	29884862	29884862	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtgccccagactcacaggCgcatttggggaccctatcgc	12	14	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr16:29884862C>T	uc002duq.3	-	13	2533	c.2293G>A	c.(2293-2295)GCC>ACC	p.A765T	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.A695T|SEZ6L2_uc002dur.3_Missense_Mutation_p.A695T|SEZ6L2_uc002dus.3_Missense_Mutation_p.A651T|SEZ6L2_uc010vec.1_Missense_Mutation_p.A765T|SEZ6L2_uc010ved.1_Missense_Mutation_p.A721T	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	765	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GACTCACAGGCGCATTTGGGG	0.672													T	29884862	T	T	29884862	3	4	191	1	0	0	0	0	1	0	0	0	14144	768	27	1	502	1	SEZ6L2	16	29884862	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	8728167	29884862	60469891	47	13577											
CMTM2	146225	broad.mit.edu	37	chr16	66613682	66613682	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacctcaaaaggcggtgcagCccaagcacgaagtgggcacg	13	12	1	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr16:66613682C>T	uc002ept.2	+	1	332	c.172C>T	c.(172-174)CCC>TCC	p.P58S	CMTM2_uc010cdu.2_Missense_Mutation_p.P58S	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	58					chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		GGCGGTGCAGCCCAAGCACGA	0.557													T	66613682	T	T	66613682	3	4	191	1	0	0	0	0	1	0	0	0	3583	739	26	3	174	3	CMTM2	16	66613682	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08	36728820	66613682	23741071	48	13578											
DNAI2	64446	broad.mit.edu	37	chr17	72308276	72308276	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggccgtagacctggaggcGctggtcagcaaggccgagga	17	11	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr17:72308276G>A	uc002jkf.2	+	12	1728	c.1629G>A	c.(1627-1629)GCG>GCA	p.A543A	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_Intron|uc002jkh.1_5'Flank|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	543					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						ACCTGGAGGCGCTGGTCAGCA	0.617									Kartagener_syndrome				A	72308276	A	A	72308276	2	1	191	1	0	0	0	0	0	0	0	1	4610	1074	38	1		1	DNAI2	17	72308276	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08		72308276	8886934	49	13579											
QRICH2	84074	broad.mit.edu	37	chr17	74276772	74276772	+	Frame_Shift_Del	DEL	T	-	-													ccaggtgctccctgttggccTtttccttttcgagcttctcc							TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr17:74276772delT	uc002jrd.1	-	10	4106	c.3926delA	c.(3925-3927)AAGfs	p.K1309fs	QRICH2_uc010wsz.1_Frame_Shift_Del_p.K1235fs|QRICH2_uc010dgw.1_Frame_Shift_Del_p.K153fs	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1309	Potential.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CCTGTTGGCCTTTTCCTTTTC	0.587													-	74276772	-	-	74276772	7	5	191	1	0	1	0	1	0	0	0	0	12880	1609	56	0	1105	0	QRICH2	17	74276772	Frame_Shift_Del	DEL	T	TCGA-27-2518-01A-01D-1494-08	1968496	74276772	6918438	50	13580											
SERPINB13	5275	broad.mit.edu	37	chr18	61255920	61255920	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatggattcacttggcgccGtcagcactcgacttgggttt	11	11	3	0	rs139825462		TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr18:61255920G>A	uc002ljc.2	+	2	187	c.19G>A	c.(19-21)GTC>ATC	p.V7I	SERPINB13_uc002ljd.2_5'UTR|SERPINB13_uc010xep.1_Missense_Mutation_p.V7I|SERPINB13_uc010xeq.1_5'UTR|SERPINB13_uc010xer.1_5'UTR	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	7					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						ACTTGGCGCCGTCAGCACTCG	0.418													A	61255920	A	A	61255920	3	1	191	1	0	0	0	0	1	0	0	0	14100	1145	40	1	21	1	SERPINB13	18	61255920	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08		61255920	16821328	51	13581											
CLEC4M	10332	broad.mit.edu	37	chr19	7833731	7833731	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgggctttgcagcttccagCggtactggaacagtggagaa	14	8	0	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr19:7833731C>T	uc002mih.2	+	8	1106	c.988C>T	c.(988-990)CGG>TGG	p.R330W	CLEC4M_uc010xjw.1_Missense_Mutation_p.R286W|CLEC4M_uc010dvt.2_Missense_Mutation_p.R307W|CLEC4M_uc010dvs.2_Missense_Mutation_p.R329W|CLEC4M_uc010xjx.1_Missense_Mutation_p.R302W|CLEC4M_uc002mhz.2_Missense_Mutation_p.A223V|CLEC4M_uc002mic.2_Missense_Mutation_p.A287V|CLEC4M_uc002mia.2_Missense_Mutation_p.R217W	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	353	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						CAGCTTCCAGCGGTACTGGAA	0.498													T	7833731	T	T	7833731	3	4	191	1	0	0	0	0	1	0	0	0	3518	768	27	1	1104	1	CLEC4M	19	7833731	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08		7833731	51295252	52	13582											
SLC1A6	6511	broad.mit.edu	37	chr19	15067440	15067440	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggtcagggtgtacatgccCagctgaccccccaggacggc	13	15	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr19:15067440C>T	uc002naa.1	-	6	1025	c.1017G>A	c.(1015-1017)CTG>CTA	p.L339L	SLC1A6_uc010dzu.1_Intron|SLC1A6_uc010xod.1_Silent_p.L275L	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	339					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	TGTACATGCCCAGCTGACCCC	0.587													T	15067440	T	T	15067440	2	4	191	1	0	0	0	0	0	0	0	1	14436	581	21	3		3	SLC1A6	19	15067440	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08	7233709	15067440	44061543	53	13583											
KCNN1	3780	broad.mit.edu	37	chr19	18084899	18084899	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggcagccccaggaccaggacGatgacgaggatgatgaggaa	16	9	0	3			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr19:18084899G>A	uc002nht.2	+	3	512	c.202G>A	c.(202-204)GAT>AAT	p.D68N	KCNN1_uc010xqa.1_Missense_Mutation_p.D68N	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	68					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						GGACCAGGACGATGACGAGGA	0.701													A	18084899	A	A	18084899	3	1	191	1	0	0	0	0	1	0	0	0	8078	1058	37	2	204	2	KCNN1	19	18084899	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08	3017459	18084899	41044084	54	13584											
PSG6	5675	broad.mit.edu	37	chr19	43414919	43414919	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaccacaggtagcttgcatcCggagtctcaggatcacagat	10	11	2	1	rs1065506		TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr19:43414919C>T	uc002ovj.1	-	3	571	c.519G>A	c.(517-519)CCG>CCA	p.P173P	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Silent_p.P180P|PSG6_uc002ovi.2_Silent_p.P174P|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_5'UTR|PSG6_uc002ovf.1_Silent_p.P173P|PSG6_uc002ovg.1_Silent_p.P173P	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	173	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				AGCTTGCATCCGGAGTCTCAG	0.532													T	43414919	T	T	43414919	2	4	191	1	0	0	0	0	0	0	0	1	12659	639	23	2		2	PSG6	19	43414919	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08	25330020	43414919	15714064	55	13585											
SIGLEC5	8778	broad.mit.edu	37	chr19	52115643	52115643	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggagatgcttgatctccGgggctgtctggccagggctt	17	9	2	2	rs141897891	byFrequency	TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr19:52115643G>A	uc002pxe.2	-	9	1636	c.1497C>T	c.(1495-1497)CCC>CCT	p.P499P		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	499	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CTTGATCTCCGGGGCTGTCTG	0.493													A	52115643	A	A	52115643	2	1	191	1	0	0	0	0	0	0	0	1	14311	1103	39	2		2	SIGLEC5	19	52115643	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08	8700724	52115643	7013340	56	13586											
NLRP5	126206	broad.mit.edu	37	chr19	56515208	56515208	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgctcaccttttccagctaCgggctgcaatggtgtctcta	9	13	2	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr19:56515208C>T	uc002qmj.2	+	2	189	c.189C>T	c.(187-189)TAC>TAT	p.Y63Y	NLRP5_uc002qmi.2_Silent_p.Y63Y	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	63	DAPIN.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTTCCAGCTACGGGCTGCAAT	0.423													T	56515208	T	T	56515208	2	4	191	1	0	0	0	0	0	0	0	1	10480	547	19	1		1	NLRP5	19	56515208	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08	4399565	56515208	2613775	57	13587											
SALL4	57167	broad.mit.edu	37	chr20	50407509	50407509	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcccaggctgcaggtcacCgggcaaggagccacccgtga	15	14	1	1			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr20:50407509C>T	uc002xwh.3	-	2	1614	c.1513G>A	c.(1513-1515)GGT>AGT	p.G505S	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	505					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGCAGGTCACCGGGCAAGGAG	0.567													T	50407509	T	T	50407509	3	4	191	1	0	0	0	0	1	0	0	0	13813	652	23	2	1660	2	SALL4	20	50407509	Missense_Mutation	SNP	C	TCGA-27-2518-01A-01D-1494-08		50407509	12618011	58	13588											
ZGPAT	84619	broad.mit.edu	37	chr20	62365995	62365995	+	Splice_Site	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccctctgtccatctcttgcAgtggtggggtcggacgccgt	14	13	2	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr20:62365995A>C	uc002ygk.2	+	5	1050	c.872_splice	c.e5-2	p.V291_splice	ZGPAT_uc002ygi.2_Intron|ZGPAT_uc002ygj.2_Intron|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Intron|ZGPAT_uc002ygm.2_Intron|ZGPAT_uc002ygn.3_Intron|LIME1_uc011abi.1_5'Flank|LIME1_uc002ygp.3_5'Flank	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain						negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					CATCTCTTGCAGTGGTGGGGT	0.622													C	62365995	C	C	62365995	5	2	191	1	0	0	0	0	0	0	1	0	17671	202	7	5	884	5	ZGPAT	20	62365995	Splice_Site	SNP	A	TCGA-27-2518-01A-01D-1494-08	11958486	62365995	659525	59	13589											
NRIP1	8204	broad.mit.edu	37	chr21	16339283	16339283	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atattcatcaatagttgtagGtgtactactttcctcaaaaa	5	7	3	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr21:16339283G>T	uc002yjx.2	-	4	1829	c.1231C>A	c.(1231-1233)CCT>ACT	p.P411T		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	411	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		ATAGTTGTAGGTGTACTACTT	0.373													T	16339283	T	T	16339283	3	4	191	1	0	0	0	0	1	0	0	0	10652	1261	44	5	2249	5	NRIP1	21	16339283	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08		16339283	31790612	60	13590											
TUBA8	51807	broad.mit.edu	37	chr22	18609536	18609536	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacctggtgccctacccccGcatccacttcccgctggtca	7	20	1	0			TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr22:18609536G>A	uc002znv.1	+	4	864	c.791G>A	c.(790-792)CGC>CAC	p.R264H	TUBA8_uc002znr.2_Missense_Mutation_p.R198H|TUBA8_uc002znw.1_Missense_Mutation_p.R288H|TUBA8_uc002znx.1_Missense_Mutation_p.R111H	NM_018943	NP_061816	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	264					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0						CCCTACCCCCGCATCCACTTC	0.567													A	18609536	A	A	18609536	3	1	191	1	0	0	0	0	1	0	0	0	16747	1087	38	1	805	1	TUBA8	22	18609536	Missense_Mutation	SNP	G	TCGA-27-2518-01A-01D-1494-08		18609536	32695030	61	13591											
SCUBE1	80274	broad.mit.edu	37	chr22	43600126	43600126	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctggggatgcgccagcacGtcgaagagggccttgatcag	15	10	2	2	rs140846155	byFrequency	TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chr22:43600126G>A	uc003bdt.1	-	22	2932	c.2844C>T	c.(2842-2844)GAC>GAT	p.D948D		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	948					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				GCGCCAGCACGTCGAAGAGGG	0.572													A	43600126	A	A	43600126	2	1	191	1	0	0	0	0	0	0	0	1	13944	1136	40	1		1	SCUBE1	22	43600126	Silent	SNP	G	TCGA-27-2518-01A-01D-1494-08	24990590	43600126	7704440	62	13592											
RAB9A	9367	broad.mit.edu	37	chrX	13727279	13727279	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caggtgtctacagaagaagcCcaagcttggtgcagggacaa	13	9	1	2	rs146572677	byFrequency	TCGA-27-2518-01A-01D-1494-08	TCGA-27-2518-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	dae099ff-330f-492b-a06d-6f975e9e5aea	54dcf632-973a-4ecc-be89-c590ba1a6ad0	g.chrX:13727279C>G	uc004cvm.2	+	3	596	c.414C>G	c.(412-414)GCC>GCG	p.A138A	RAB9A_uc010neh.2_Silent_p.A138A	NM_004251	NP_004242	P51151	RAB9A_HUMAN	RAB9A, member RAS oncogene family	138					protein transport|small GTPase mediated signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome|lysosome|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding	p.A138V(1)		ovary(1)	1						CAGAAGAAGCCCAAGCTTGGT	0.458													G	13727279	G	G	13727279	2	3	191	1	0	0	0	0	0	0	0	1	12958	610	22	5		5	RAB9A	23	13727279	Silent	SNP	C	TCGA-27-2518-01A-01D-1494-08		13727279	141543281	63	13593											
CHD5	26038	broad.mit.edu	37	chr1	6172293	6172293	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcttcctctttgtcaccatTttgctgtgtttcaatgggct	7	10	4	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr1:6172293T>G	uc001amb.1	-	35	5147	c.5047A>C	c.(5047-5049)AAT>CAT	p.N1683H	CHD5_uc001alz.1_Missense_Mutation_p.N540H|CHD5_uc001ama.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1683					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TTGTCACCATTTTGCTGTGTT	0.433													G	6172293	G	G	6172293	3	3	192	1	0	0	0	0	1	0	0	0	3328	1841	64	5	845	5	CHD5	1	6172293	Missense_Mutation	SNP	T	TCGA-27-2519-01A-01D-1494-08		6172293	243078328	1	13594											
AIM1L	55057	broad.mit.edu	37	chr1	26658052	26658052	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgtgagagtggggaactcGccctcagagagaatgtgctg	16	9	1	3			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr1:26658052G>A	uc001bmd.3	-	14	1537	c.1107C>T	c.(1105-1107)GGC>GGT	p.G369G		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	369	Beta/gamma crystallin 'Greek key' 8.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		TGGGGAACTCGCCCTCAGAGA	0.567													A	26658052	A	A	26658052	2	1	192	1	0	0	0	0	0	0	0	1	431	1074	38	1		1	AIM1L	1	26658052	Silent	SNP	G	TCGA-27-2519-01A-01D-1494-08	20485759	26658052	222592569	2	13595											
WDR65	149465	broad.mit.edu	37	chr1	43663300	43663300	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggtctagctacctgcatccGcaaaccccttatagccacct	6	17	1	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr1:43663300G>A	uc001cip.1	+	7	1320	c.1199G>A	c.(1198-1200)CGC>CAC	p.R400H	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Missense_Mutation_p.R389H|WDR65_uc001ciq.1_Missense_Mutation_p.R400H	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	400	WD 5.									skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACCTGCATCCGCAAACCCCTT	0.458													A	43663300	A	A	43663300	3	1	192	1	0	0	0	0	1	0	0	0	17313	1087	38	1	1221	1	WDR65	1	43663300	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	17005248	43663300	205587321	3	13596											
PTPRF	5792	broad.mit.edu	37	chr1	44069848	44069848	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcatccagtcccggaccatgCcggtggagcaaggtgtgtgc	15	12	0	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr1:44069848C>T	uc001cjr.2	+	16	3365	c.3025C>T	c.(3025-3027)CCG>TCG	p.P1009S	PTPRF_uc001cjs.2_Missense_Mutation_p.P1000S|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Missense_Mutation_p.P569S|PTPRF_uc001cjv.2_Missense_Mutation_p.P469S|PTPRF_uc001cjw.2_Missense_Mutation_p.P235S	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1009	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCGGACCATGCCGGTGGAGCA	0.617													T	44069848	T	T	44069848	3	4	192	1	0	0	0	0	1	0	0	0	12801	739	26	3	3079	3	PTPRF	1	44069848	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	406548	44069848	205180773	4	13597											
TCHH	7062	broad.mit.edu	37	chr1	152080572	152080572	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgttcctcctggaggaatttTctctctcgttcctgacggcg	10	12	2	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr1:152080572T>A	uc001ezp.2	-	2	5121	c.5121A>T	c.(5119-5121)AGA>AGT	p.R1707S	TCHH_uc009wne.1_Missense_Mutation_p.R1707S	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1707	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGGAATTTTCTCTCTCGTT	0.587													A	152080572	A	A	152080572	3	1	192	1	0	0	0	0	1	0	0	0	15697	1780	62	5	714	5	TCHH	1	152080572	Missense_Mutation	SNP	T	TCGA-27-2519-01A-01D-1494-08	108010724	152080572	97170049	5	13598											
TCHH	7062	broad.mit.edu	37	chr1	152081047	152081047	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctgtcacggtcctgacgcCgctgttgcccgcgctcctgg	12	16	2	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr1:152081047C>T	uc001ezp.2	-	2	4646	c.4646G>A	c.(4645-4647)CGG>CAG	p.R1549Q	TCHH_uc009wne.1_Missense_Mutation_p.R1549Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1549	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCTGACGCCGCTGTTGCCC	0.607													T	152081047	T	T	152081047	3	4	192	1	0	0	0	0	1	0	0	0	15697	652	23	2	1189	2	TCHH	1	152081047	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	475	152081047	97169574	6	13599											
OR2M2	391194	broad.mit.edu	37	chr1	248344068	248344068	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctttgttcatgtacataCggcccacatctgatcactcc	6	14	3	1	rs150685608		TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr1:248344068C>T	uc010pzf.1	+	1	781	c.781C>T	c.(781-783)CGG>TGG	p.R261W		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CATGTACATACGGCCCACATC	0.517													T	248344068	T	T	248344068	3	4	192	1	0	0	0	0	1	0	0	0	11010	527	19	1	783	1	OR2M2	1	248344068	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	96263021	248344068	906553	7	13600											
C2orf89	129293	broad.mit.edu	37	chr2	85051138	85051138	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgcggcctccgctgtgaccGcctccgcttcttccggaacc	10	19	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr2:85051138G>A	uc010ysl.1	-	6	1362	c.1273C>T	c.(1273-1275)CGG>TGG	p.R425W	C2orf89_uc002sou.3_Missense_Mutation_p.R376W	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	425	Extracellular (Potential).					integral to membrane				ovary(1)	1						CGCTGTGACCGCCTCCGCTTC	0.652													A	85051138	A	A	85051138	3	1	192	1	0	0	0	0	1	0	0	0	2203	1086	38	1	252	1	C2orf89	2	85051138	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08		85051138	158148235	8	13601											
SCN9A	6335	broad.mit.edu	37	chr2	167055444	167055444	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattttgccttaagcggtaaCgtctataagcacgctgaatg	9	9	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr2:167055444C>T	uc010fpl.2	-	27	6013	c.5672G>A	c.(5671-5673)CGT>CAT	p.R1891H	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1902	IQ.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TAAGCGGTAACGTCTATAAGC	0.363													T	167055444	T	T	167055444	3	4	192	1	0	0	0	0	1	0	0	0	13925	536	19	1	265	1	SCN9A	2	167055444	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	82004306	167055444	76143929	9	13602											
PDE1A	5136	broad.mit.edu	37	chr2	183066517	183066517	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcactaggttccgaagatccCtgcagagtcaccaaaaggag	10	11	2	2			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr2:183066517C>G	uc002uos.2	-	10	1035	c.951_splice	c.e10-1	p.R317_splice	PDE1A_uc010zfp.1_Splice_Site_p.R213_splice|PDE1A_uc002uoq.1_Splice_Site_p.R317_splice|PDE1A_uc010zfq.1_Splice_Site_p.R317_splice|PDE1A_uc002uor.2_Splice_Site_p.R301_splice|PDE1A_uc002uou.2_Splice_Site_p.R283_splice	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2						activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			CCGAAGATCCCTGCAGAGTCA	0.289													G	183066517	G	G	183066517	5	3	192	1	0	0	0	0	0	0	1	0	11633	695	24	5	759	5	PDE1A	2	183066517	Splice_Site	SNP	C	TCGA-27-2519-01A-01D-1494-08	16011073	183066517	60132856	10	13603											
PASK	23178	broad.mit.edu	37	chr2	242054741	242054741	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccaccctggatagaattgCgatctctaaagtaactttcc	6	12	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr2:242054741C>T	uc002wao.1	-	13	3252	c.3160G>A	c.(3160-3162)GCA>ACA	p.A1054T	PASK_uc010zol.1_Missense_Mutation_p.A868T|PASK_uc010zom.1_Missense_Mutation_p.A1019T|PASK_uc010fzl.1_Missense_Mutation_p.A1054T|PASK_uc010zon.1_Missense_Mutation_p.A835T|PASK_uc002wap.2_Missense_Mutation_p.A597T|PASK_uc002waq.2_Missense_Mutation_p.A1054T	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	1054	Protein kinase.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GATAGAATTGCGATCTCTAAA	0.433													T	242054741	T	T	242054741	3	4	192	1	0	0	0	0	1	0	0	0	11472	768	27	1	835	1	PASK	2	242054741	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	58988224	242054741	1144632	11	13604											
OR5H6	79295	broad.mit.edu	37	chr3	97983628	97983628	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	attagtcttgtcatttatagGtggccttcttcatgctttaa	7	7	4	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr3:97983628G>C	uc003dsi.1	+	1	500	c.500G>C	c.(499-501)GGT>GCT	p.G167A		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	167	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						TCATTTATAGGTGGCCTTCTT	0.348													C	97983628	C	C	97983628	3	2	192	1	0	0	0	0	1	0	0	0	11163	1261	44	5	502	5	OR5H6	3	97983628	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08		97983628	100038802	12	13605											
REST	5978	broad.mit.edu	37	chr4	57797807	57797807	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctggacaaaacttgaataCgccagagggtgaaactttaa	9	8	1	3			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr4:57797807C>T	uc003hch.2	+	4	3130	c.2783C>T	c.(2782-2784)ACG>ATG	p.T928M	REST_uc003hci.2_Missense_Mutation_p.T928M|REST_uc010ihf.2_Missense_Mutation_p.T602M	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	928					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					AACTTGAATACGCCAGAGGGT	0.413													T	57797807	T	T	57797807	3	4	192	1	0	0	0	0	1	0	0	0	13234	536	19	1	2793	1	REST	4	57797807	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08		57797807	133356469	13	13606											
NDST4	64579	broad.mit.edu	37	chr4	115997685	115997685	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttgtgtacttggtaagctgtTctcattggctttatgaaaac	9	6	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr4:115997685T>A	uc003ibu.2	-	2	1187	c.508A>T	c.(508-510)AAC>TAC	p.N170Y	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	170	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GGTAAGCTGTTCTCATTGGCT	0.368													A	115997685	A	A	115997685	3	1	192	1	0	0	0	0	1	0	0	0	10258	1783	62	5	2162	5	NDST4	4	115997685	Missense_Mutation	SNP	T	TCGA-27-2519-01A-01D-1494-08	58199878	115997685	75156591	14	13607											
KLKB1	3818	broad.mit.edu	37	chr4	187173239	187173239	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttggggagagtggccctggCaggtgagcctgcaggtgaag	19	8	0	3	rs61733605		TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr4:187173239C>A	uc003iyy.2	+	11	1284	c.1213C>A	c.(1213-1215)CAG>AAG	p.Q405K	KLKB1_uc011clc.1_Missense_Mutation_p.Q203K|KLKB1_uc011cld.1_Missense_Mutation_p.Q367K	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	405	Peptidase S1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GTGGCCCTGGCAGGTGAGCCT	0.542													A	187173239	A	A	187173239	3	1	192	1	0	0	0	0	1	0	0	0	8412	711	25	5	1251	5	KLKB1	4	187173239	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	71175554	187173239	3981037	15	13608											
RAB3C	115827	broad.mit.edu	37	chr5	57913622	57913622	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gactcctttacatctgcattCgtcagcacagttgggatcga	9	11	2	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr5:57913622C>T	uc003jrp.2	+	2	274	c.177C>T	c.(175-177)TTC>TTT	p.F59F		NM_138453	NP_612462	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	59	Effector region (By similarity).				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)|central_nervous_system(1)	2		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		CATCTGCATTCGTCAGCACAG	0.383													T	57913622	T	T	57913622	2	4	192	1	0	0	0	0	0	0	0	1	12933	883	31	2		2	RAB3C	5	57913622	Silent	SNP	C	TCGA-27-2519-01A-01D-1494-08		57913622	123001638	16	13609											
MAP1B	4131	broad.mit.edu	37	chr5	71493036	71493036	+	Frame_Shift_Del	DEL	A	-	-													cttctctctgacgcccaatgAgattaaagtctctgcagagg							TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr5:71493036delA	uc003kbw.3	+	5	4095	c.3854delA	c.(3853-3855)GAGfs	p.E1285fs	MAP1B_uc010iyw.1_Frame_Shift_Del_p.E1302fs|MAP1B_uc010iyx.1_Frame_Shift_Del_p.E1159fs|MAP1B_uc010iyy.1_Frame_Shift_Del_p.E1159fs	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1285						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ACGCCCAATGAGATTAAAGTC	0.527													-	71493036	-	-	71493036	7	5	192	1	0	1	0	1	0	0	0	0	9228	304	11	0	3872	0	MAP1B	5	71493036	Frame_Shift_Del	DEL	A	TCGA-27-2519-01A-01D-1494-08	13579414	71493036	109422224	17	13610											
SV2C	22987	broad.mit.edu	37	chr5	75428035	75428035	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atggtcgttttcagtgggccCttttcttcgtcctgggcatg	12	10	2	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr5:75428035C>A	uc003kei.1	+	2	594	c.460C>A	c.(460-462)CTT>ATT	p.L154I		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	154	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TCAGTGGGCCCTTTTCTTCGT	0.527													A	75428035	A	A	75428035	3	1	192	1	0	0	0	0	1	0	0	0	15416	681	24	5	462	5	SV2C	5	75428035	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	3934999	75428035	105487225	18	13611											
GABRA1	2554	broad.mit.edu	37	chr5	161324208	161324208	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taatttggccaggggcgaccCgggcttagccaccattgcta	12	12	0	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr5:161324208C>T	uc010jiw.2	+	11	1619	c.1151C>T	c.(1150-1152)CCG>CTG	p.P384L	GABRA1_uc010jix.2_Missense_Mutation_p.P384L|GABRA1_uc010jiy.2_Missense_Mutation_p.P384L|GABRA1_uc003lyx.3_Missense_Mutation_p.P384L|GABRA1_uc010jiz.2_Missense_Mutation_p.P384L|GABRA1_uc010jja.2_Missense_Mutation_p.P384L|GABRA1_uc010jjb.2_Missense_Mutation_p.P384L	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	384	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	AGGGGCGACCCGGGCTTAGCC	0.458													T	161324208	T	T	161324208	3	4	192	1	0	0	0	0	1	0	0	0	6160	652	23	2	1185	2	GABRA1	5	161324208	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	85896173	161324208	19591052	19	13612											
PKHD1	5314	broad.mit.edu	37	chr6	51910930	51910930	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtacctggatgtgaagtcatCggcattattctgtaagagct	11	7	2	2			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr6:51910930C>T	uc003pah.1	-	24	2740	c.2464G>A	c.(2464-2466)GAT>AAT	p.D822N	PKHD1_uc003pai.2_Missense_Mutation_p.D822N	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	822	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTGAAGTCATCGGCATTATTC	0.443													T	51910930	T	T	51910930	3	4	192	1	0	0	0	0	1	0	0	0	11971	884	31	2	9975	2	PKHD1	6	51910930	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08		51910930	119204137	20	13613											
EZR	7430	broad.mit.edu	37	chr6	159192358	159192358	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgtcaggcttcctgcggcGcatatacaactcatggttgc	12	11	2	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr6:159192358G>A	uc003qrt.3	-	8	1092	c.877C>T	c.(877-879)CGC>TGC	p.R293C	EZR_uc011efr.1_5'Flank|EZR_uc011efs.1_Missense_Mutation_p.R261C|EZR_uc003qru.3_Missense_Mutation_p.R293C	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	293	Interaction with SCYL3.|FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TTCCTGCGGCGCATATACAAC	0.572													A	159192358	A	A	159192358	3	1	192	1	0	0	0	0	1	0	0	0	5335	1087	38	1	907	1	EZR	6	159192358	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	107281428	159192358	11922709	21	13614											
FAM126A	84668	broad.mit.edu	37	chr7	22985627	22985627	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agttttgcttcctcctgaccGtctgtggttctttcctatac	7	12	2	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr7:22985627G>A	uc003svm.3	-	11	1402	c.1147C>T	c.(1147-1149)CGG>TGG	p.R383W	FAM126A_uc003svn.3_3'UTR	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	383						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						CCTCCTGACCGTCTGTGGTTC	0.438													A	22985627	A	A	22985627	3	1	192	1	0	0	0	0	1	0	0	0	5429	1144	40	1	422	1	FAM126A	7	22985627	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08		22985627	136153036	22	13615											
AMPH	273	broad.mit.edu	37	chr7	38516566	38516566	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctgctgcgcttggcgatgcGattctgtcaacaggaaatgc	12	11	2	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr7:38516566G>A	uc003tgu.2	-	6	469	c.400C>T	c.(400-402)CGC>TGC	p.R134C	AMPH_uc003tgv.2_Missense_Mutation_p.R134C	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	134	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TTGGCGATGCGATTCTGTCAA	0.522													A	38516566	A	A	38516566	3	1	192	1	0	0	0	0	1	0	0	0	588	1058	37	2	1751	2	AMPH	7	38516566	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	15530939	38516566	120622097	23	13616											
ABCA13	154664	broad.mit.edu	37	chr7	48287865	48287865	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgcaagaggtcattacttgGcacaaaaatatgtcagtttt	8	6	2	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr7:48287865G>T	uc003toq.2	+	14	1714	c.1689G>T	c.(1687-1689)TGG>TGT	p.W563C	ABCA13_uc010kyr.2_Missense_Mutation_p.W66C	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	563					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TCATTACTTGGCACAAAAATA	0.388													T	48287865	T	T	48287865	3	4	192	1	0	0	0	0	1	0	0	0	31	1212	42	5	1572	5	ABCA13	7	48287865	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	9771299	48287865	110850798	24	13617											
TRPV6	55503	broad.mit.edu	37	chr7	142572296	142572296	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tctggaatcctcgggcgaagTacatgacgttgcaccagccc	11	13	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr7:142572296T>A	uc003wbx.1	-	11	1616	c.1400A>T	c.(1399-1401)TAC>TTC	p.Y467F	TRPV6_uc003wbw.1_Missense_Mutation_p.Y253F|TRPV6_uc010lou.1_Missense_Mutation_p.Y338F	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	467	Helical; (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					TCGGGCGAAGTACATGACGTT	0.577													A	142572296	A	A	142572296	3	1	192	1	0	0	0	0	1	0	0	0	16597	1638	57	5	797	5	TRPV6	7	142572296	Missense_Mutation	SNP	T	TCGA-27-2519-01A-01D-1494-08	94284431	142572296	16566367	25	13618											
ARHGEF5	7984	broad.mit.edu	37	chr7	144062310	144062310	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccatcatagaccctcccaccGaaccacccccattgccccca	3	23	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr7:144062310G>A	uc003wel.2	+	2	2666	c.2548G>A	c.(2548-2550)GAA>AAA	p.E850K	ARHGEF5_uc003wek.2_Missense_Mutation_p.E850K|ARHGEF5_uc003wem.2_5'Flank	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	850					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					CCCTCCCACCGAACCACCCCC	0.587													A	144062310	A	A	144062310	3	1	192	1	0	0	0	0	1	0	0	0	909	1059	37	2	2550	2	ARHGEF5	7	144062310	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	1490014	144062310	15076353	26	13619											
ZNF786	136051	broad.mit.edu	37	chr7	148768162	148768162	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagcccttgccacactcccCgcacgagaacggcctctcct	8	19	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr7:148768162C>T	uc003wfh.2	-	4	1839	c.1702G>A	c.(1702-1704)GGG>AGG	p.G568R	ZNF786_uc011kuk.1_Missense_Mutation_p.G531R|ZNF786_uc003wfi.2_Missense_Mutation_p.G482R	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	568	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CCACACTCCCCGCACGAGAAC	0.632													T	148768162	T	T	148768162	3	4	192	1	0	0	0	0	1	0	0	0	18155	652	23	2	650	2	ZNF786	7	148768162	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	4705852	148768162	10370501	27	13620											
HTR5A	3361	broad.mit.edu	37	chr7	154875908	154875908	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagatggtgttcacggtccGccacgccaccgtcaccttcc	9	18	2	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr7:154875908G>A	uc003wlu.1	+	2	849	c.785G>A	c.(784-786)CGC>CAC	p.R262H		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	262	Cytoplasmic (By similarity).		R -> C (in a colorectal cancer sample; somatic mutation).			integral to plasma membrane	serotonin receptor activity	p.R262C(1)		ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TTCACGGTCCGCCACGCCACC	0.607													A	154875908	A	A	154875908	3	1	192	1	0	0	0	0	1	0	0	0	7450	1087	38	1	791	1	HTR5A	7	154875908	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	6107746	154875908	4262755	28	13621											
TEX15	56154	broad.mit.edu	37	chr8	30701172	30701172	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcacattcattaacctgtcGtttgtactttaagaatacat	4	8	2	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr8:30701172G>A	uc003xil.2	-	1	5362	c.5362C>T	c.(5362-5364)CGA>TGA	p.R1788*		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1788										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTAACCTGTCGTTTGTACTTT	0.343													A	30701172	A	A	30701172	4	1	192	1	0	0	0	0	0	1	0	0	15776	1153	40	1	3023	1	TEX15	8	30701172	Nonsense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08		30701172	115662850	29	13622											
TRIM55	84675	broad.mit.edu	37	chr8	67040581	67040581	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caagaggaggtaccaccatgGcatcagggggccgattccgc	14	12	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr8:67040581G>T	uc003xvv.2	+	2	437	c.211G>T	c.(211-213)GCA>TCA	p.A71S	TRIM55_uc003xvu.2_Missense_Mutation_p.A71S|TRIM55_uc003xvw.2_Missense_Mutation_p.A71S|TRIM55_uc003xvx.2_Missense_Mutation_p.A71S	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	71						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			TACCACCATGGCATCAGGGGG	0.493													T	67040581	T	T	67040581	3	4	192	1	0	0	0	0	1	0	0	0	16526	1203	42	5	217	5	TRIM55	8	67040581	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	36339409	67040581	79323441	30	13623											
ZHX2	22882	broad.mit.edu	37	chr8	123965254	123965254	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaggggcatcgtccacatcAccagcgaatcccttgccaaa	8	14	1	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr8:123965254A>C	uc003ypk.1	+	3	2071	c.1504A>C	c.(1504-1506)ACC>CCC	p.T502P		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	502						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CGTCCACATCACCAGCGAATC	0.572													C	123965254	C	C	123965254	3	2	192	1	0	0	0	0	1	0	0	0	17673	159	6	5	1506	5	ZHX2	8	123965254	Missense_Mutation	SNP	A	TCGA-27-2519-01A-01D-1494-08	56924673	123965254	22398768	31	13624											
FER1L6	654463	broad.mit.edu	37	chr8	125110086	125110086	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	attttagaggatgagaatatCttcacaggccaaaaatcaag	8	6	3	2			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr8:125110086C>A	uc003yqw.2	+	37	5051	c.4845C>A	c.(4843-4845)ATC>ATA	p.I1615I	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1615	C2 6.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ATGAGAATATCTTCACAGGCC	0.408													A	125110086	A	A	125110086	2	1	192	1	0	0	0	0	0	0	0	1	5815	903	32	5		5	FER1L6	8	125110086	Silent	SNP	C	TCGA-27-2519-01A-01D-1494-08	1144832	125110086	21253936	32	13625											
RAD23B	5887	broad.mit.edu	37	chr9	110084381	110084383	+	In_Frame_Del	DEL	ACA	-	-													caactacgacagcaacaactAcaacaacaagttctggaggt							TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr9:110084381_110084383delACA	uc004bde.2	+	7	1166_1168	c.799_801delACA	c.(799-801)ACAdel	p.T269del	RAD23B_uc011lwa.1_In_Frame_Del_p.T269del|RAD23B_uc011lwb.1_In_Frame_Del_p.T248del	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	269	Poly-Thr.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						AGCAACAACTACAACAACAAGTT	0.468								Direct_reversal_of_damage|NER					-	110084383	-	-	110084381	7	5	192	1	0	1	0	1	0	0	0	0	12983	391	14	0	825	0	RAD23B	9	110084381	In_Frame_Del	DEL	ACA	TCGA-27-2519-01A-01D-1494-08		110084381	31129050	33	13626											
PTPN3	5774	broad.mit.edu	37	chr9	112153417	112153417	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatccagattcctaacttaCgttcacgtaacttgcattaa	4	11	2	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr9:112153417C>T	uc004bed.2	-	21	2218	c.2106_splice	c.e21+1	p.N702_splice	PTPN3_uc004beb.2_Splice_Site_p.N571_splice|PTPN3_uc004bec.2_Splice_Site_p.N526_splice|PTPN3_uc010mtu.2_Splice_Site|PTPN3_uc011lwg.1_Splice_Site_p.N657_splice|PTPN3_uc011lwh.1_Splice_Site_p.N548_splice|PTPN3_uc011lwd.1_Splice_Site_p.N170_splice|PTPN3_uc011lwe.1_Splice_Site_p.N415_splice|PTPN3_uc011lwf.1_Splice_Site_p.N370_splice	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type						negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						TCCTAACTTACGTTCACGTAA	0.358													T	112153417	T	T	112153417	5	4	192	1	0	0	0	0	0	0	1	0	12789	550	19	1	658	1	PTPN3	9	112153417	Splice_Site	SNP	C	TCGA-27-2519-01A-01D-1494-08	2069036	112153417	29060014	34	13627											
C10orf113	387638	broad.mit.edu	37	chr10	21435284	21435284	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actctacctgttcatgtctgGaatgtacatttcagccacac	6	12	4	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr10:21435284G>A	uc001iqm.2	-	1	144	c.124C>T	c.(124-126)CCA>TCA	p.P42S	NEBL_uc001iqk.2_Intron	NM_001010896	NP_001010896	Q5VZT2	CJ113_HUMAN	hypothetical protein LOC387638	52										ovary(3)|pancreas(1)	4						TTCATGTCTGGAATGTACATT	0.443													A	21435284	A	A	21435284	3	1	192	1	0	0	0	0	1	0	0	0	1584	1174	41	3	356	3	C10orf113	10	21435284	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08		21435284	114099463	35	13628											
PTEN	5728	broad.mit.edu	37	chr10	89711899	89711899	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taactattcccagtcagaggCgctatgtgtattattatagc	8	8	1	1	rs121913293		TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr10:89711899C>T	uc001kfb.2	+	7	1548	c.517C>T	c.(517-519)CGC>TGC	p.R173C		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	173	Phosphatase tensin-type.		R -> C (in endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3; retains ability to bind phospholipid membranes).|R -> P (loss of phosphatase activity towards Ins(1,3,4,5)P4).|R -> H (loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R173C(32)|p.R173H(22)|p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.R173fs*10(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G165_K342del(1)|p.G165_*404del(1)|p.R173R(1)|p.R173P(1)|p.R172fs*5(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CAGTCAGAGGCGCTATGTGTA	0.348	R173C(REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89711899	T	T	89711899	3	4	192	1	0	0	0	0	1	0	0	0	12738	768	27	1	539	1	PTEN	10	89711899	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	68276615	89711899	45822848	36	13629											
DNMBP	23268	broad.mit.edu	37	chr10	101654794	101654794	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttttctgtttcttcaaatActtcatcttttatctgttca	2	8	7	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr10:101654794A>G	uc001kqj.2	-	11	3157	c.3065T>C	c.(3064-3066)GTA>GCA	p.V1022A	DNMBP_uc010qpl.1_5'UTR|DNMBP_uc001kqg.2_Missense_Mutation_p.V310A|DNMBP_uc001kqh.2_Missense_Mutation_p.V654A	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1022	BAR.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TTCTTCAAATACTTCATCTTT	0.353													G	101654794	G	G	101654794	3	3	192	1	0	0	0	0	1	0	0	0	4674	391	14	4	1696	4	DNMBP	10	101654794	Missense_Mutation	SNP	A	TCGA-27-2519-01A-01D-1494-08	11942895	101654794	33879953	37	13630											
SORCS1	114815	broad.mit.edu	37	chr10	108389034	108389034	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacggtcacacggaaaatgCccacgttctgatagacgtgt	11	11	2	2			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr10:108389034C>T	uc001kym.2	-	19	2596	c.2588G>A	c.(2587-2589)GGC>GAC	p.G863D	SORCS1_uc001kyl.2_Missense_Mutation_p.G863D|SORCS1_uc009xxs.2_Missense_Mutation_p.G863D|SORCS1_uc001kyn.1_Missense_Mutation_p.G863D|SORCS1_uc001kyo.2_Missense_Mutation_p.G863D	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	863	Lumenal (Potential).|PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACGGAAAATGCCCACGTTCTG	0.483													T	108389034	T	T	108389034	3	4	192	1	0	0	0	0	1	0	0	0	14930	739	26	3	1184	3	SORCS1	10	108389034	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	6734240	108389034	27145713	38	13631											
RAB11FIP2	22841	broad.mit.edu	37	chr10	119798511	119798511	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggcattatatttgaagcccTgaattttgctgtaaatggat	9	5	0	2			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr10:119798511T>C	uc001ldj.1	-	3	1677	c.1237A>G	c.(1237-1239)AGG>GGG	p.R413G	RAB11FIP2_uc009xyz.1_Missense_Mutation_p.R413G	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	413					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		TTTGAAGCCCTGAATTTTGCT	0.343													C	119798511	C	C	119798511	3	2	192	1	0	0	0	0	1	0	0	0	12894	1579	55	4	313	4	RAB11FIP2	10	119798511	Missense_Mutation	SNP	T	TCGA-27-2519-01A-01D-1494-08	11409477	119798511	15736236	39	13632											
GRM5	2915	broad.mit.edu	37	chr11	88780659	88780659	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggagccatccacacagcGtaccaagccttcttcctctt	8	15	2	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr11:88780659G>A	uc001pcq.2	-	1	582	c.382C>T	c.(382-384)CGC>TGC	p.R128C	GRM5_uc009yvm.2_Missense_Mutation_p.R128C|GRM5_uc009yvn.1_Missense_Mutation_p.R128C	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	128	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R128H(1)		central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TCCACACAGCGTACCAAGCCT	0.522													A	88780659	A	A	88780659	3	1	192	1	0	0	0	0	1	0	0	0	6800	1145	40	1	3292	1	GRM5	11	88780659	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08		88780659	46225857	40	13633											
ANO4	121601	broad.mit.edu	37	chr12	101480464	101480464	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtggtgattgctgccgtgttCgggatcgtcatttaccgggt	15	8	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr12:101480464C>T	uc010svm.1	+	17	2135	c.1563C>T	c.(1561-1563)TTC>TTT	p.F521F	ANO4_uc001thw.2_Silent_p.F486F|ANO4_uc001thx.2_Silent_p.F521F|ANO4_uc001thy.2_Silent_p.F41F	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	521	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CTGCCGTGTTCGGGATCGTCA	0.517										HNSCC(74;0.22)			T	101480464	T	T	101480464	2	4	192	1	0	0	0	0	0	0	0	1	699	883	31	2		2	ANO4	12	101480464	Silent	SNP	C	TCGA-27-2519-01A-01D-1494-08		101480464	32371431	41	13634											
EML1	2009	broad.mit.edu	37	chr14	100363508	100363508	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtacaggggtcgagactgccGtaacaacctgtacttgcttc	11	11	0	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr14:100363508G>A	uc001ygs.2	+	7	773	c.704G>A	c.(703-705)CGT>CAT	p.R235H	EML1_uc010avt.1_Missense_Mutation_p.R222H|EML1_uc010tww.1_Missense_Mutation_p.R223H|EML1_uc001ygq.2_Missense_Mutation_p.R254H|EML1_uc001ygr.2_Missense_Mutation_p.R254H	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	235						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				CGAGACTGCCGTAACAACCTG	0.468													A	100363508	A	A	100363508	3	1	192	1	0	0	0	0	1	0	0	0	5096	1145	40	1	791	1	EML1	14	100363508	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08		100363508	6986032	42	13635											
CIB2	10518	broad.mit.edu	37	chr15	78403609	78403609	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggccagctcatagaatcgCgaatgcagccttggaggaaa	14	9	1	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr15:78403609C>T	uc002bdb.1	-	3	417	c.96G>A	c.(94-96)TCG>TCA	p.S32S	CIB2_uc002bdc.1_5'UTR|CIB2_uc010ums.1_Silent_p.S32S	NM_006383	NP_006374	O75838	CIB2_HUMAN	DNA-dependent protein kinase catalytic	32							calcium ion binding				0						CATAGAATCGCGAATGCAGCC	0.612													T	78403609	T	T	78403609	2	4	192	1	0	0	0	0	0	0	0	1	3421	755	27	1		1	CIB2	15	78403609	Silent	SNP	C	TCGA-27-2519-01A-01D-1494-08		78403609	24127783	43	13636											
ACSM2B	348158	broad.mit.edu	37	chr16	20570756	20570756	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accacagggctgggcttgggAgtcgcttgccagcctgagga	16	11	0	1	rs74479331		TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr16:20570756A>G	uc002dhj.3	-	4	401	c.191T>C	c.(190-192)CTC>CCC	p.L64P	ACSM2B_uc002dhk.3_Missense_Mutation_p.L64P|ACSM2B_uc010bwf.1_Missense_Mutation_p.L64P	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	64					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TGGGCTTGGGAGTCGCTTGCC	0.512													G	20570756	G	G	20570756	3	3	192	1	0	0	0	0	1	0	0	0	184	304	11	4	1590	4	ACSM2B	16	20570756	Missense_Mutation	SNP	A	TCGA-27-2519-01A-01D-1494-08		20570756	69783997	44	13637											
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Frame_Shift_Del	DEL	G	-	-													attctcttcctctgtgcgccGgtctctcccaggacaggcac					rs28934574		TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr17:7577094delG	uc002gim.2	-	8	1038	c.844delC	c.(844-846)CGGfs	p.R282fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.R282fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.R150fs|TP53_uc010cng.1_Frame_Shift_Del_p.R150fs|TP53_uc002gii.1_Frame_Shift_Del_p.R150fs|TP53_uc010cnh.1_Frame_Shift_Del_p.R282fs|TP53_uc010cni.1_Frame_Shift_Del_p.R282fs|TP53_uc002gij.2_Frame_Shift_Del_p.R282fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			-	7577094	-	-	7577094	7	5	192	1	0	1	0	1	0	0	0	0	16378	1115	39	0	442	0	TP53	17	7577094	Frame_Shift_Del	DEL	G	TCGA-27-2519-01A-01D-1494-08		7577094	73618116	45	13638											
SGCA	6442	broad.mit.edu	37	chr17	48245006	48245006	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggacacccagacctgccccGgtggctccgctacacccagc	11	19	0	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr17:48245006G>A	uc002iqi.2	+	3	257	c.221G>A	c.(220-222)CGG>CAG	p.R74Q	SGCA_uc010wmh.1_Intron|SGCA_uc002iqj.2_Missense_Mutation_p.R74Q|SGCA_uc010wmi.1_RNA	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	74	Extracellular (Potential).		R -> W (in LGMD2D).		muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						GACCTGCCCCGGTGGCTCCGC	0.657													A	48245006	A	A	48245006	3	1	192	1	0	0	0	0	1	0	0	0	14199	1116	39	2	231	2	SGCA	17	48245006	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	40667912	48245006	32950204	46	13639											
ARHGAP28	79822	broad.mit.edu	37	chr18	6859897	6859897	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttcccaggagtgactctgtgGtaagtcatccatgtcagcac	10	11	3	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr18:6859897G>T	uc010wzi.1	+	4	433	c.195_splice	c.e4+1	p.V65_splice	ARHGAP28_uc002knc.2_Splice_Site_p.V190_splice|ARHGAP28_uc002knd.2_Splice_Site_p.V83_splice|ARHGAP28_uc002kne.2_Splice_Site_p.V83_splice|ARHGAP28_uc002knf.2_Splice_Site_p.V74_splice			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;						signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				TGACTCTGTGGTAAGTCATCC	0.428													T	6859897	T	T	6859897	5	4	192	1	0	0	0	0	0	0	1	0	877	1275	44	5	260	5	ARHGAP28	18	6859897	Splice_Site	SNP	G	TCGA-27-2519-01A-01D-1494-08		6859897	71217351	47	13640											
SIGLEC11	114132	broad.mit.edu	37	chr19	50462137	50462137	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caggaccgggagggatgtgcCgttcccgaggttttccagga	16	10	0	0	rs142292396	byFrequency	TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr19:50462137C>A	uc010ybh.1	-	7	1217	c.1126G>T	c.(1126-1128)GGC>TGC	p.G376C	SIGLEC11_uc010ybi.1_Missense_Mutation_p.G376C	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	376	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		AGGGATGTGCCGTTCCCGAGG	0.662													A	50462137	A	A	50462137	3	1	192	1	0	0	0	0	1	0	0	0	14307	652	23	5	990	5	SIGLEC11	19	50462137	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08		50462137	8666846	48	13641											
KLK15	55554	broad.mit.edu	37	chr19	51329907	51329907	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgcgcctctgccctccgcGcctgcacacaccatggtgtt	9	18	2	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr19:51329907G>A	uc002ptl.2	-	4	619	c.588C>T	c.(586-588)GGC>GGT	p.G196G	KLK1_uc002ptk.1_5'Flank|KLK1_uc010ycg.1_5'Flank|KLK15_uc002ptm.2_Intron|KLK15_uc002ptn.2_Intron|KLK15_uc002pto.2_Silent_p.G195G|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_Intron|KLK15_uc010eod.2_Intron	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	196	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		TGCCCTCCGCGCCTGCACACA	0.582													A	51329907	A	A	51329907	2	1	192	1	0	0	0	0	0	0	0	1	8403	1074	38	1		1	KLK15	19	51329907	Silent	SNP	G	TCGA-27-2519-01A-01D-1494-08	867770	51329907	7799076	49	13642											
BRSK1	84446	broad.mit.edu	37	chr19	55814187	55814187	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agagagcatggcatcactggGctgcttcagggaccgcgaga	15	10	2	2			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr19:55814187G>C	uc002qkg.2	+	10	1257	c.980G>C	c.(979-981)GGC>GCC	p.G327A	BRSK1_uc002qkf.2_Missense_Mutation_p.G343A|BRSK1_uc002qkh.2_Missense_Mutation_p.G22A	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	327	UBA.			G->A: Abolishes activation of kinase activity.	establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity	p.G327D(1)		ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCATCACTGGGCTGCTTCAGG	0.682													C	55814187	C	C	55814187	3	2	192	1	0	0	0	0	1	0	0	0	1523	1203	42	5	1018	5	BRSK1	19	55814187	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	4484280	55814187	3314796	50	13643											
TM9SF4	9777	broad.mit.edu	37	chr20	30745712	30745712	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccatatgacaaccctgtgcGcaccaaccagattccccggc	8	17	0	2			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr20:30745712G>A	uc002wxj.2	+	14	1680	c.1445G>A	c.(1444-1446)CGC>CAC	p.R482H	TM9SF4_uc010zts.1_Missense_Mutation_p.R389H|TM9SF4_uc002wxk.2_Missense_Mutation_p.R465H|TM9SF4_uc010gdz.2_Missense_Mutation_p.R361H	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	482						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AACCCTGTGCGCACCAACCAG	0.587													A	30745712	A	A	30745712	3	1	192	1	0	0	0	0	1	0	0	0	15977	1087	38	1	1499	1	TM9SF4	20	30745712	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08		30745712	32279808	51	13644											
MC3R	4159	broad.mit.edu	37	chr20	54824428	54824428	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgctgcggcgtctgtggcGtggtgttcatcgtctactcg	14	11	4	0			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr20:54824428G>A	uc002xxb.2	+	1	641	c.529G>A	c.(529-531)GTG>ATG	p.V177M		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	214	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			CGTCTGTGGCGTGGTGTTCAT	0.562													A	54824428	A	A	54824428	3	1	192	1	0	0	0	0	1	0	0	0	9365	1145	40	1	531	1	MC3R	20	54824428	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08	24078716	54824428	8201092	52	13645											
HUNK	30811	broad.mit.edu	37	chr21	33370854	33370854	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagattcctttggctgccGcaatattttccgcaaaacct	7	12	0	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chr21:33370854G>A	uc002yph.2	+	11	1862	c.1502G>A	c.(1501-1503)CGC>CAC	p.R501H		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	501					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						TTTGGCTGCCGCAATATTTTC	0.527													A	33370854	A	A	33370854	3	1	192	1	0	0	0	0	1	0	0	0	7458	1087	38	1	1544	1	HUNK	21	33370854	Missense_Mutation	SNP	G	TCGA-27-2519-01A-01D-1494-08		33370854	14759041	53	13646											
ARSF	416	broad.mit.edu	37	chrX	2994636	2994636	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaaggcgtgcgactgactcAgcacatctctgccgcctccc	11	16	2	1			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chrX:2994636A>C	uc004cre.1	+	4	430	c.209A>C	c.(208-210)CAG>CCG	p.Q70P	ARSF_uc004crf.1_Missense_Mutation_p.Q70P	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	70						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGACTGACTCAGCACATCTCT	0.483													C	2994636	C	C	2994636	3	2	192	1	0	0	0	0	1	0	0	0	991	188	7	5	219	5	ARSF	23	2994636	Missense_Mutation	SNP	A	TCGA-27-2519-01A-01D-1494-08		2994636	152275924	54	13647											
PHKA1	5255	broad.mit.edu	37	chrX	71821869	71821869	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctgagattgacagtctaCgaaattccacctgaaacata	7	10	1	3			TCGA-27-2519-01A-01D-1494-08	TCGA-27-2519-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b0daafab-b783-4cfc-9f7d-8017d98e80bb	8c4df672-e807-4afa-aa62-d2574c5fe0ef	g.chrX:71821869C>T	uc004eax.3	-	28	3345	c.3044G>A	c.(3043-3045)CGT>CAT	p.R1015H	PHKA1_uc004eay.3_Intron|PHKA1_uc011mqi.1_Intron	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	1015					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					TGACAGTCTACGAAATTCCAC	0.358													T	71821869	T	T	71821869	3	4	192	1	0	0	0	0	1	0	0	0	11843	536	19	1	647	1	PHKA1	23	71821869	Missense_Mutation	SNP	C	TCGA-27-2519-01A-01D-1494-08	68827233	71821869	83448691	55	13648											
NPHP4	261734	broad.mit.edu	37	chr1	5969267	5969267	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaactcgaggtactggcgctGgcgggcctgggaggaagcac	18	10	0	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:5969267G>C	uc001alq.1	-	12	1714	c.1448C>G	c.(1447-1449)CCA>CGA	p.P483R	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_Intron|NPHP4_uc001alt.1_Intron	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	483					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TACTGGCGCTGGCGGGCCTGG	0.642													C	5969267	C	C	5969267	3	2	193	1	0	0	0	0	1	0	0	0	10581	1348	47	5	2908	5	NPHP4	1	5969267	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08		5969267	243281354	1	13649											
PRAMEF2	65122	broad.mit.edu	37	chr1	12918957	12918957	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctctgccatggaggagctGcccagggtgctctatctccc	11	14	3	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:12918957G>A	uc001aum.1	+	2	180	c.93G>A	c.(91-93)CTG>CTA	p.L31L		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	31											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGGAGGAGCTGCCCAGGGTGC	0.622													A	12918957	A	A	12918957	2	1	193	1	0	0	0	0	0	0	0	1	12435	1306	46	3		3	PRAMEF2	1	12918957	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08	6949690	12918957	236331664	2	13650											
MACF1	23499	broad.mit.edu	37	chr1	39753206	39753206	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caatctccgatttgtgtatgAactactgtcttgggtagaag	10	7	2	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:39753206A>T	uc010ois.1	+	16	1977	c.1772A>T	c.(1771-1773)GAA>GTA	p.E591V	MACF1_uc001cda.1_Missense_Mutation_p.E499V	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	591					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTTGTGTATGAACTACTGTCT	0.463													T	39753206	T	T	39753206	3	4	193	1	0	0	0	0	1	0	0	0	9144	246	9	5	1826	5	MACF1	1	39753206	Missense_Mutation	SNP	A	TCGA-27-2521-01A-01D-1494-08	26834249	39753206	209497415	3	13651											
FAAH	2166	broad.mit.edu	37	chr1	46871972	46871972	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagcctggcactgtgcctgCgagccctgctgtgtgaggac	15	12	0	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:46871972C>T	uc001cpu.2	+	7	965	c.883C>T	c.(883-885)CGA>TGA	p.R295*	FAAH_uc001cpv.2_Intron	NM_001441	NP_001432	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	295	Cytoplasmic (By similarity).				fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	ACTGTGCCTGCGAGCCCTGCT	0.642											OREG0013458	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	46871972	T	T	46871972	4	4	193	1	0	0	0	0	0	1	0	0	5353	760	27	1	909	1	FAAH	1	46871972	Nonsense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	7118766	46871972	202378649	4	13652											
HOOK1	51361	broad.mit.edu	37	chr1	60312821	60312821	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	attgactagtcttgcagaagAaacaagagccctgaaagatg	10	7	1	6			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:60312821A>T	uc009wad.2	+	11	995	c.893A>T	c.(892-894)GAA>GTA	p.E298V	HOOK1_uc001czo.2_Missense_Mutation_p.E298V|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Missense_Mutation_p.E256V	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	298	Potential.|Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					CTTGCAGAAGAAACAAGAGCC	0.348													T	60312821	T	T	60312821	3	4	193	1	0	0	0	0	1	0	0	0	7282	246	9	5	931	5	HOOK1	1	60312821	Missense_Mutation	SNP	A	TCGA-27-2521-01A-01D-1494-08	13440849	60312821	188937800	5	13653											
PDE4B	5142	broad.mit.edu	37	chr1	66831413	66831413	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctgccatccatgacgttgatCatcctggagtctccaatcag	8	13	3	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:66831413C>T	uc001dcn.2	+	13	1539	c.1348C>T	c.(1348-1350)CAT>TAT	p.H450Y	PDE4B_uc009war.2_Missense_Mutation_p.H358Y|PDE4B_uc001dco.2_Missense_Mutation_p.H450Y|PDE4B_uc001dcp.2_Missense_Mutation_p.H435Y|PDE4B_uc001dcq.2_Missense_Mutation_p.H278Y|PDE4B_uc009was.2_Missense_Mutation_p.H217Y	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	450					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	TGACGTTGATCATCCTGGAGT	0.418													T	66831413	T	T	66831413	3	4	193	1	0	0	0	0	1	0	0	0	11640	826	29	3	1752	3	PDE4B	1	66831413	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	6518592	66831413	182419208	6	13654											
SLC44A3	126969	broad.mit.edu	37	chr1	95322914	95322914	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcccaggttatggaaggcGgccaagtggaatataagccc	13	10	0	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:95322914G>A	uc001dqv.3	+	10	1203	c.1096G>A	c.(1096-1098)GGC>AGC	p.G366S	SLC44A3_uc001dqx.3_Missense_Mutation_p.G366S|SLC44A3_uc010otq.1_Missense_Mutation_p.G298S|SLC44A3_uc010otr.1_Missense_Mutation_p.G330S|SLC44A3_uc001dqw.3_Missense_Mutation_p.G318S|SLC44A3_uc010ots.1_Missense_Mutation_p.G286S|SLC44A3_uc009wds.2_Missense_Mutation_p.G269S|SLC44A3_uc010ott.1_Missense_Mutation_p.G286S|SLC44A3_uc010otu.1_RNA	NM_001114106	NP_001107578	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3 isoform 1	366						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)	1		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	TATGGAAGGCGGCCAAGTGGA	0.458													A	95322914	A	A	95322914	3	1	193	1	0	0	0	0	1	0	0	0	14637	1116	39	2	1134	2	SLC44A3	1	95322914	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	28491501	95322914	153927707	7	13655											
FLG2	388698	broad.mit.edu	37	chr1	152327770	152327770	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	actcatgctgtccaaagccaGaggattgtcctgagccagac	10	12	1	3			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:152327770G>T	uc001ezw.3	-	3	2565	c.2492C>A	c.(2491-2493)TCT>TAT	p.S831Y	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	831	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCAAAGCCAGAGGATTGTCC	0.517													T	152327770	T	T	152327770	3	4	193	1	0	0	0	0	1	0	0	0	5923	942	33	5	4687	5	FLG2	1	152327770	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	57004856	152327770	96922851	8	13656											
GORAB	92344	broad.mit.edu	37	chr1	170508571	170508571	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catttcactctcacctccccCgttggtgatggacaaccaca	6	16	2	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:170508571C>T	uc001gha.2	+	2	384	c.357C>T	c.(355-357)CCC>CCT	p.P119P	GORAB_uc009wvw.2_3'UTR|GORAB_uc001ggz.3_Silent_p.P119P|GORAB_uc009wvx.2_5'UTR|GORAB_uc001ghb.2_5'UTR|GORAB_uc001ghc.2_5'UTR	NM_152281	NP_689494	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting isoform a	119						Golgi apparatus|nucleus					0						TCACCTCCCCCGTTGGTGATG	0.468													T	170508571	T	T	170508571	2	4	193	1	0	0	0	0	0	0	0	1	6574	639	23	2		2	GORAB	1	170508571	Silent	SNP	C	TCGA-27-2521-01A-01D-1494-08	18180801	170508571	78742050	9	13657											
NEK7	140609	broad.mit.edu	37	chr1	198262082	198262082	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtttttttgcagttggtacGccttattacatgtctccaga	8	8	1	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:198262082G>A	uc001gun.3	+	8	924	c.597G>A	c.(595-597)ACG>ACA	p.T199T		NM_133494	NP_598001	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	199	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|lung(1)|ovary(1)	4						CAGTTGGTACGCCTTATTACA	0.323													A	198262082	A	A	198262082	2	1	193	1	0	0	0	0	0	0	0	1	10329	1074	38	1		1	NEK7	1	198262082	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08	27753511	198262082	50988539	10	13658											
HNRNPU	3192	broad.mit.edu	37	chr1	245025769	245025769	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	acagcttcacttacaagtatCaagacaaaccactgtgtcat	5	11	3	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr1:245025769C>G	uc001iaz.1	-	3	1089	c.871G>C	c.(871-873)GAT>CAT	p.D291H	HNRNPU_uc001iax.1_5'Flank|HNRNPU_uc001iay.1_5'Flank|HNRNPU_uc001iba.1_Missense_Mutation_p.D272H|HNRNPU_uc001ibb.1_5'UTR	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	291	B30.2/SPRY.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			TTACAAGTATCAAGACAAACC	0.378													G	245025769	G	G	245025769	3	3	193	1	0	0	0	0	1	0	0	0	7273	826	29	5	1654	5	HNRNPU	1	245025769	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	46763687	245025769	4224852	11	13659											
ATP6V1C2	245973	broad.mit.edu	37	chr2	10912727	10912727	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcagacatggtggtccctcGatcaaccaagtaagtgagac	10	11	2	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr2:10912727G>A	uc002ras.2	+	8	738	c.629G>A	c.(628-630)CGA>CAA	p.R210Q	ATP6V1C2_uc002rat.2_Missense_Mutation_p.R210Q	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a	210					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		GTGGTCCCTCGATCAACCAAG	0.507													A	10912727	A	A	10912727	3	1	193	1	0	0	0	0	1	0	0	0	1181	1058	37	2	655	2	ATP6V1C2	2	10912727	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08		10912727	232286646	12	13660											
TET3	200424	broad.mit.edu	37	chr2	74328397	74328397	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccagtgggggctgttcccCggtgaggggcagcaggcagc	20	11	0	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr2:74328397C>T	uc002skb.3	+	9	4077	c.4077C>T	c.(4075-4077)CCC>CCT	p.P1359P		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	1359							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GGCTGTTCCCCGGTGAGGGGC	0.657													T	74328397	T	T	74328397	2	4	193	1	0	0	0	0	0	0	0	1	15768	639	23	2		2	TET3	2	74328397	Silent	SNP	C	TCGA-27-2521-01A-01D-1494-08	63415670	74328397	168870976	13	13661											
RANBP2	5903	broad.mit.edu	37	chr2	109388156	109388156	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttttttgactggtgttacaGcaaaagagaagaaaaaacct	8	5	0	3			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr2:109388156G>A	uc002tem.3	+	21	7976	c.7850_splice	c.e21-1	p.A2617_splice		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TGGTGTTACAGCAAAAGAGAA	0.348													A	109388156	A	A	109388156	5	1	193	1	0	0	0	0	0	0	1	0	13028	985	34	3	7931	3	RANBP2	2	109388156	Splice_Site	SNP	G	TCGA-27-2521-01A-01D-1494-08	35059759	109388156	133811217	14	13662											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	193	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	99724956	209113112	34086261	15	13663											
SCLY	51540	broad.mit.edu	37	chr2	239002554	239002554	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttatgaggcccacatgagggAcgtccgcgactacctggaag	13	11	0	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr2:239002554A>T	uc010fyv.2	+	9	1038	c.974A>T	c.(973-975)GAC>GTC	p.D325V	SCLY_uc002vxm.3_Missense_Mutation_p.D292V|SCLY_uc002vxn.2_3'UTR|SCLY_uc010znq.1_Missense_Mutation_p.D119V|SCLY_uc010znr.1_Missense_Mutation_p.D231V|SCLY_uc002vxp.3_5'Flank	NM_016510	NP_057594	Q96I15	SCLY_HUMAN	selenocysteine lyase	325					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			ovary(2)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		CACATGAGGGACGTCCGCGAC	0.622													T	239002554	T	T	239002554	3	4	193	1	0	0	0	0	1	0	0	0	13907	275	10	5	1008	5	SCLY	2	239002554	Missense_Mutation	SNP	A	TCGA-27-2521-01A-01D-1494-08	29889442	239002554	4196819	16	13664											
STAB1	23166	broad.mit.edu	37	chr3	52536060	52536060	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaccccatgcaatggccacGggacctgcttggatggcatg	13	12	0	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr3:52536060G>A	uc003dej.2	+	4	444	c.370G>A	c.(370-372)GGG>AGG	p.G124R	STAB1_uc003dei.1_Missense_Mutation_p.G124R	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	124	EGF-like 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CAATGGCCACGGGACCTGCTT	0.637													A	52536060	A	A	52536060	3	1	193	1	0	0	0	0	1	0	0	0	15236	1116	39	2	384	2	STAB1	3	52536060	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08		52536060	145486370	17	13665											
MINA	84864	broad.mit.edu	37	chr3	97664110	97664110	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgtagtaagtttcaggtccTtgacagaaatagctggacta	10	7	1	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr3:97664110T>C	uc003drz.1	-	10	1822	c.1316A>G	c.(1315-1317)AAG>AGG	p.K439R	MINA_uc003dry.1_Missense_Mutation_p.K110R|MINA_uc003dsa.1_Missense_Mutation_p.K438R|MINA_uc003dsb.1_Missense_Mutation_p.K439R|MINA_uc003dsc.1_Missense_Mutation_p.K438R	NM_001042533	NP_001035998	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen isoform a	439					ribosome biogenesis	cytoplasm|nucleolus				ovary(1)	1						TTTCAGGTCCTTGACAGAAAT	0.383													C	97664110	C	C	97664110	3	2	193	1	0	0	0	0	1	0	0	0	9586	1609	56	4	85	4	MINA	3	97664110	Missense_Mutation	SNP	T	TCGA-27-2521-01A-01D-1494-08	45128050	97664110	100358320	18	13666											
EAF2	55840	broad.mit.edu	37	chr3	121554141	121554141	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aggagagtaattatgaatagCgcagcgggattctcacacct	11	8	1	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr3:121554141C>A	uc003een.2	+	1	108	c.9C>A	c.(7-9)AGC>AGA	p.S3R	IQCB1_uc010hre.1_5'Flank|IQCB1_uc003eek.2_5'Flank|IQCB1_uc010hrf.1_5'Flank|EAF2_uc003eem.2_RNA|EAF2_uc003eeo.2_5'UTR	NM_018456	NP_060926	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	3					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding				0				GBM - Glioblastoma multiforme(114;0.0972)		TTATGAATAGCGCAGCGGGAT	0.572													A	121554141	A	A	121554141	3	1	193	1	0	0	0	0	1	0	0	0	4876	767	27	5	11	5	EAF2	3	121554141	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	23890031	121554141	76468289	19	13667											
CLSTN2	64084	broad.mit.edu	37	chr3	140281698	140281698	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaggtgctacatcacatccGctaccgcaactggcgtccgg	11	15	1	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr3:140281698G>A	uc003etn.2	+	14	2448	c.2258G>A	c.(2257-2259)CGC>CAC	p.R753H		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	753	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CATCACATCCGCTACCGCAAC	0.552										HNSCC(16;0.037)			A	140281698	A	A	140281698	3	1	193	1	0	0	0	0	1	0	0	0	3562	1087	38	1	2312	1	CLSTN2	3	140281698	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	18727557	140281698	57740732	20	13668											
LRRIQ4	344657	broad.mit.edu	37	chr3	169555374	169555374	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctccaaaagataagaaaggAaagaaggatgtaaaaggaaa	10	3	1	3			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr3:169555374A>G	uc003fgb.2	+	5	1638	c.1638A>G	c.(1636-1638)GGA>GGG	p.G546G		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	546											0						ATAAGAAAGGAAAGAAGGATG	0.363													G	169555374	G	G	169555374	2	3	193	1	0	0	0	0	0	0	0	1	9031	233	9	4		4	LRRIQ4	3	169555374	Silent	SNP	A	TCGA-27-2521-01A-01D-1494-08	29273676	169555374	28467056	21	13669											
SLC7A14	57709	broad.mit.edu	37	chr3	170219101	170219101	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcagatcctgtggtcttgGggactcgaactccaaactct	11	11	2	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr3:170219101G>A	uc003fgz.2	-	3	654	c.338C>T	c.(337-339)CCC>CTC	p.P113L	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	113						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			TGTGGTCTTGGGGACTCGAAC	0.507													A	170219101	A	A	170219101	3	1	193	1	0	0	0	0	1	0	0	0	14696	1232	43	3	2001	3	SLC7A14	3	170219101	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	663727	170219101	27803329	22	13670											
CSF2	1437	broad.mit.edu	37	chr5	131409784	131409784	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttctacagaatgaaacagTagaagtcatctcagaaatgt	7	6	3	4			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr5:131409784T>C	uc003kwf.2	+	2	202	c.170T>C	c.(169-171)GTA>GCA	p.V57A		NM_000758	NP_000749	P04141	CSF2_HUMAN	colony stimulating factor 2 precursor	57					immune response|negative regulation of cytolysis|positive regulation of DNA replication|positive regulation of interleukin-23 production|positive regulation of macrophage derived foam cell differentiation|positive regulation of podosome assembly|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|growth factor activity				0		all_cancers(142;4.28e-07)|all_lung(232;2.81e-05)|Lung NSC(810;0.000693)|Lung SC(612;0.122)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Sargramostim(DB00020)	AATGAAACAGTAGAAGTCATC	0.517													C	131409784	C	C	131409784	3	2	193	1	0	0	0	0	1	0	0	0	3933	1638	57	4	176	4	CSF2	5	131409784	Missense_Mutation	SNP	T	TCGA-27-2521-01A-01D-1494-08		131409784	49505476	23	13671											
PDE6A	5145	broad.mit.edu	37	chr5	149323959	149323959	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtacatgaacaggctcatgCggtctgcctgcaggaggaag	15	9	2	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr5:149323959C>T	uc003lrg.3	-	1	398	c.278G>A	c.(277-279)CGC>CAC	p.R93H		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	93	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CAGGCTCATGCGGTCTGCCTG	0.522													T	149323959	T	T	149323959	3	4	193	1	0	0	0	0	1	0	0	0	11645	768	27	1	2392	1	PDE6A	5	149323959	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	17914175	149323959	31591301	24	13672											
SOX30	11063	broad.mit.edu	37	chr5	157065654	157065654	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgagcagcactggagacGctgggctggaaaagtgtgac	15	9	0	3			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr5:157065654G>A	uc003lxb.1	-	4	1806	c.1464C>T	c.(1462-1464)AGC>AGT	p.S488S	SOX30_uc003lxc.1_Intron|SOX30_uc011dds.1_Silent_p.S183S	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	488					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CACTGGAGACGCTGGGCTGGA	0.532													A	157065654	A	A	157065654	2	1	193	1	0	0	0	0	0	0	0	1	14952	1078	38	1		1	SOX30	5	157065654	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08	7741695	157065654	23849606	25	13673											
FARS2	10667	broad.mit.edu	37	chr6	5613545	5613545	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gatctcatagacaagtttgtAcatccaaagtaagtgaaaag	8	6	1	2	rs147628137		TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr6:5613545A>T	uc010jnv.1	+	6	1545	c.1209A>T	c.(1207-1209)GTA>GTT	p.V403V	FARS2_uc003mwr.2_Silent_p.V403V	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	403	FDX-ACB.				phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	ACAAGTTTGTACATCCAAAGT	0.393													T	5613545	T	T	5613545	2	4	193	1	0	0	0	0	0	0	0	1	5678	378	14	5		5	FARS2	6	5613545	Silent	SNP	A	TCGA-27-2521-01A-01D-1494-08		5613545	165501522	26	13674											
MDC1	9656	broad.mit.edu	37	chr6	30680501	30680501	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgctgagacttcttcctcGtcatctgtatcgctgttgat	9	11	3	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr6:30680501G>A	uc003nrg.3	-	5	1658	c.1218C>T	c.(1216-1218)GAC>GAT	p.D406D	MDC1_uc003nrf.3_Silent_p.D60D|MDC1_uc011dmp.1_Silent_p.D278D|MDC1_uc003nrh.1_Silent_p.D278D|MDC1_uc003nri.2_Silent_p.D406D	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	406	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CTTCTTCCTCGTCATCTGTAT	0.522								Other_conserved_DNA_damage_response_genes					A	30680501	A	A	30680501	2	1	193	1	0	0	0	0	0	0	0	1	9403	1136	40	1		1	MDC1	6	30680501	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08	25066956	30680501	140434566	27	13675											
LTA	4049	broad.mit.edu	37	chr6	31540609	31540609	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgctggttctgctgccTggggcccaggtgaggcagca	16	12	1	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr6:31540609T>C	uc011dnu.1	+	2	303	c.90T>C	c.(88-90)CCT>CCC	p.P30P	LTA_uc003nue.1_Silent_p.P30P|LTA_uc003nuf.2_5'Flank|LTA_uc003nuh.2_5'Flank|LTA_uc003nug.2_5'Flank|LTA_uc010jsr.2_5'Flank|TNF_uc003nui.2_5'Flank	NM_001159740	NP_001153212	P01374	TNFB_HUMAN	lymphotoxin alpha precursor	30					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding				0					Etanercept(DB00005)	TTCTGCTGCCTGGGGCCCAGG	0.632													C	31540609	C	C	31540609	2	2	193	1	0	0	0	0	0	0	0	1	9068	1567	55	4		4	LTA	6	31540609	Silent	SNP	T	TCGA-27-2521-01A-01D-1494-08	860108	31540609	139574458	28	13676											
GRM4	2914	broad.mit.edu	37	chr6	34003985	34003985	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaggtggtggcatagcacagGaagatgcctgccagcagcac	14	10	0	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr6:34003985G>A	uc003oir.3	-	8	2072	c.1902C>T	c.(1900-1902)TTC>TTT	p.F634F	GRM4_uc011dsn.1_Silent_p.F587F|GRM4_uc010jvh.2_Silent_p.F634F|GRM4_uc010jvi.2_Silent_p.F326F|GRM4_uc003oio.2_Silent_p.F326F|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Silent_p.F494F|GRM4_uc003oiq.2_Silent_p.F501F|GRM4_uc011dsm.1_Silent_p.F465F	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	634	Helical; Name=2; (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CATAGCACAGGAAGATGCCTG	0.592													A	34003985	A	A	34003985	2	1	193	1	0	0	0	0	0	0	0	1	6799	1165	41	3		3	GRM4	6	34003985	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08	2463376	34003985	137111082	29	13677											
LAMA2	3908	broad.mit.edu	37	chr6	129663557	129663557	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatactatggaattgtcaagGgattgccaaatgactgtcag	11	6	2	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr6:129663557G>T	uc003qbn.2	+	30	4486	c.4381G>T	c.(4381-4383)GGA>TGA	p.G1461*	LAMA2_uc003qbo.2_Nonsense_Mutation_p.G1461*	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1461	Laminin EGF-like 15.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AATTGTCAAGGGATTGCCAAA	0.403													T	129663557	T	T	129663557	4	4	193	1	0	0	0	0	0	1	0	0	8606	1233	43	5	4499	5	LAMA2	6	129663557	Nonsense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	95659572	129663557	41451510	30	13678											
HIVEP2	3097	broad.mit.edu	37	chr6	143093267	143093267	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgtgataggactgctgcTgcacctgctgagatggagag	16	7	0	3			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr6:143093267T>C	uc003qjd.2	-	5	3352	c.2609A>G	c.(2608-2610)CAG>CGG	p.Q870R		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GGACTGCTGCTGCACCTGCTG	0.557													C	143093267	C	C	143093267	3	2	193	1	0	0	0	0	1	0	0	0	7187	1580	55	4	4755	4	HIVEP2	6	143093267	Missense_Mutation	SNP	T	TCGA-27-2521-01A-01D-1494-08	13429710	143093267	28021800	31	13679											
ARID1B	57492	broad.mit.edu	37	chr6	157488293	157488293	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcgccgccctacagcatggCgcccgccatggtgaacagct	13	16	0	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr6:157488293C>T	uc003qqn.2	+	9	2938	c.2786C>T	c.(2785-2787)GCG>GTG	p.A929V	ARID1B_uc003qqo.2_Missense_Mutation_p.A942V|ARID1B_uc003qqp.2_Missense_Mutation_p.A929V|ARID1B_uc010kjl.2_Missense_Mutation_p.A127V	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	987					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TACAGCATGGCGCCCGCCATG	0.597													T	157488293	T	T	157488293	3	4	193	1	0	0	0	0	1	0	0	0	914	768	27	1	3037	1	ARID1B	6	157488293	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	14395026	157488293	13626774	32	13680											
ITGB8	3696	broad.mit.edu	37	chr7	20420296	20420296	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttcccacacagtgactacAatttagactgcatgcctccc	5	14	0	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr7:20420296A>G	uc003suu.2	+	5	1348	c.643A>G	c.(643-645)AAT>GAT	p.N215D	ITGB8_uc011jyh.1_Missense_Mutation_p.N80D|ITGB8_uc003sut.2_Missense_Mutation_p.N215D	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	215	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						CAGTGACTACAATTTAGACTG	0.388													G	20420296	G	G	20420296	3	3	193	1	0	0	0	0	1	0	0	0	7901	130	5	4	661	4	ITGB8	7	20420296	Missense_Mutation	SNP	A	TCGA-27-2521-01A-01D-1494-08		20420296	138718367	33	13681											
MTERF	7978	broad.mit.edu	37	chr7	91503603	91503603	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtttaggttgttattggaccGaaaaaaggattcaggagaac	12	4	1	1	rs148973867		TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr7:91503603G>A	uc003ulb.1	-	2	549	c.505C>T	c.(505-507)CGG>TGG	p.R169W	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Missense_Mutation_p.R169W|MTERF_uc011khm.1_Missense_Mutation_p.R149W|MTERF_uc010leu.1_Missense_Mutation_p.R149W	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	169	Interaction with DNA.			R->A: Strongly reduces affinity for DNA. Strongly reduces transcription termination.	DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			TTATTGGACCGAAAAAAGGAT	0.398													A	91503603	A	A	91503603	3	1	193	1	0	0	0	0	1	0	0	0	9918	1057	37	2	698	2	MTERF	7	91503603	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	71083307	91503603	67635060	34	13682											
ORC5L	5001	broad.mit.edu	37	chr7	103835638	103835638	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caaacggctcaaagcatccaGtatttggacgaaacttttcc	7	11	1	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr7:103835638G>T	uc003vcb.2	-	5	617	c.506C>A	c.(505-507)ACT>AAT	p.T169N	ORC5L_uc011klp.1_Missense_Mutation_p.T37N|ORC5L_uc003vcc.2_Missense_Mutation_p.T169N|ORC5L_uc003vcd.2_Missense_Mutation_p.T169N	NM_002553	NP_002544	O43913	ORC5_HUMAN	origin recognition complex subunit 5 isoform 1	169					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding				0						AAAGCATCCAGTATTTGGACG	0.343													T	103835638	T	T	103835638	3	4	193	1	0	0	0	0	1	0	0	0	11265	1029	36	5	939	5	ORC5L	7	103835638	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	12332035	103835638	55303025	35	13683											
STAR	6770	broad.mit.edu	37	chr8	38005844	38005844	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agagtctcttctagccgagaAcctggatacacagccgagga	11	11	2	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr8:38005844A>G	uc003xkv.1	-	3	444	c.180T>C	c.(178-180)GGT>GGC	p.G60G	STAR_uc010lwc.1_Silent_p.G22G	NM_001007243	NP_001007244	P49675	STAR_HUMAN	steroidogenic acute regulatory protein isoform	60					C21-steroid hormone biosynthetic process	mitochondrial intermembrane space	cholesterol transporter activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.0151)|Lung NSC(58;0.0295)		READ - Rectum adenocarcinoma(644;0.188)		CTAGCCGAGAACCTGGATACA	0.577													G	38005844	G	G	38005844	2	3	193	1	0	0	0	0	0	0	0	1	15253	57	2	4		4	STAR	8	38005844	Silent	SNP	A	TCGA-27-2521-01A-01D-1494-08		38005844	108358178	36	13684											
GDF6	392255	broad.mit.edu	37	chr8	97157751	97157751	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agaggagtgtgcgagagatcGtctgcgagataaaaaataat	13	4	1	3			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr8:97157751G>C	uc003yhp.2	-	2	508	c.408C>G	c.(406-408)GAC>GAG	p.D136E		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	136					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					GCGAGAGATCGTCTGCGAGAT	0.557													C	97157751	C	C	97157751	3	2	193	1	0	0	0	0	1	0	0	0	6317	1159	40	5	963	5	GDF6	8	97157751	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	59151907	97157751	49206271	37	13685											
IFNW1	3467	broad.mit.edu	37	chr9	21141019	21141019	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctctatctttacttctcagtCtttcttgcatgtttgttgat	5	9	5	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr9:21141019C>G	uc003zol.1	-	1	1126	c.551G>C	c.(550-552)AGA>ACA	p.R184T		NM_002177	NP_002168	P05000	IFNW1_HUMAN	interferon, omega 1 precursor	184					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding				0				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ACTTCTCAGTCTTTCTTGCAT	0.383													G	21141019	G	G	21141019	3	3	193	1	0	0	0	0	1	0	0	0	7552	913	32	5	40	5	IFNW1	9	21141019	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08		21141019	120072412	38	13686											
IFNW1	3467	broad.mit.edu	37	chr9	21141108	21141108	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tcgctgtatttcttctctttCaggtagacacggattccctg	8	11	3	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr9:21141108C>G	uc003zol.1	-	1	1037	c.462G>C	c.(460-462)CTG>CTC	p.L154L		NM_002177	NP_002168	P05000	IFNW1_HUMAN	interferon, omega 1 precursor	154					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding				0				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TCTTCTCTTTCAGGTAGACAC	0.473													G	21141108	G	G	21141108	2	3	193	1	0	0	0	0	0	0	0	1	7552	813	29	5		5	IFNW1	9	21141108	Silent	SNP	C	TCGA-27-2521-01A-01D-1494-08	89	21141108	120072323	39	13687											
TMEM2	23670	broad.mit.edu	37	chr9	74324239	74324239	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catttacacagcttggatggCggatcaggtagttgtccatt	11	8	1	0	rs147272925	byFrequency	TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr9:74324239C>T	uc011lsa.1	-	17	3461	c.2921G>A	c.(2920-2922)CGC>CAC	p.R974H	TMEM2_uc010mos.2_Missense_Mutation_p.R911H|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	974						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		GCTTGGATGGCGGATCAGGTA	0.448													T	74324239	T	T	74324239	3	4	193	1	0	0	0	0	1	0	0	0	16118	768	27	1	1262	1	TMEM2	9	74324239	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	53183131	74324239	66889192	40	13688											
ZNF618	114991	broad.mit.edu	37	chr9	116811982	116811982	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gagaacttcaaggtgcacccGgcccacaaggtggccatgat	12	12	1	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr9:116811982G>T	uc004bid.2	+	15	2499	c.2400G>T	c.(2398-2400)CCG>CCT	p.P800P	ZNF618_uc004bic.2_Silent_p.P707P|ZNF618_uc011lxi.1_Silent_p.P767P|ZNF618_uc011lxj.1_Silent_p.P768P|ZNF618_uc010mvb.2_Silent_p.P390P	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	800					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGTGCACCCGGCCCACAAGG	0.612													T	116811982	T	T	116811982	2	4	193	1	0	0	0	0	0	0	0	1	18039	1103	39	5		5	ZNF618	9	116811982	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08	42487743	116811982	24401449	41	13689											
DEC1	50514	broad.mit.edu	37	chr9	118162691	118162691	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cagcacctggtgagggccttCttgccgtgttacacatgatg	12	11	1	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr9:118162691C>G	uc004bjk.1	+	6	586	c.67C>G	c.(67-69)CTT>GTT	p.L23V	DEC1_uc004bjl.1_Intron	NM_017418	NP_059114	Q9P2X7	DEC1_HUMAN	deleted in esophageal cancer 1	23					negative regulation of cell proliferation					ovary(1)	1						tgagggccttcttgccgtgtt	0													G	118162691	G	G	118162691	3	3	193	1	0	0	0	0	1	0	0	0	4381	913	32	5	73	5	DEC1	9	118162691	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	1350709	118162691	23050740	42	13690											
ASTN2	23245	broad.mit.edu	37	chr9	119204775	119204775	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agtggacaggccgtcctcagGgtcaccgtgcttagctctga	13	12	3	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr9:119204775G>T	uc004bjs.1	-	21	3656	c.3555C>A	c.(3553-3555)ACC>ACA	p.T1185T	ASTN2_uc004bjr.1_Silent_p.T1181T|ASTN2_uc004bjt.1_Silent_p.T1134T|ASTN2_uc004bjp.1_Silent_p.T278T|ASTN2_uc004bjq.1_Silent_p.T237T|ASTN2_uc011lxr.1_Silent_p.T237T|ASTN2_uc011lxs.1_Silent_p.T237T|ASTN2_uc011lxt.1_Silent_p.T237T|ASTN2_uc004bjo.1_5'UTR	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1185	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CCGTCCTCAGGGTCACCGTGC	0.512													T	119204775	T	T	119204775	2	4	193	1	0	0	0	0	0	0	0	1	1065	1219	43	5		5	ASTN2	9	119204775	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08	1042084	119204775	22008656	43	13691											
GLT6D1	360203	broad.mit.edu	37	chr9	138517954	138517954	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggcccacagtgatattcCgccttctgtaatgtttttcc	7	13	1	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr9:138517954C>T	uc010nbd.1	-	4	472	c.218G>A	c.(217-219)CGG>CAG	p.R73Q		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	73	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		AGTGATATTCCGCCTTCTGTA	0.498													T	138517954	T	T	138517954	3	4	193	1	0	0	0	0	1	0	0	0	6468	652	23	2	620	2	GLT6D1	9	138517954	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	19313179	138517954	2695477	44	13692											
C10orf18	54906	broad.mit.edu	37	chr10	5804609	5804609	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccatttaggagtagctattGgtaagaacactttttatgta	8	5	0	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr10:5804609G>A	uc001iij.2	+	20	7914	c.7289G>A	c.(7288-7290)TGG>TAG	p.W2430*	C10orf18_uc001iik.2_Nonsense_Mutation_p.W1274*	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2430										ovary(1)|central_nervous_system(1)	2						AGTAGCTATTGGTAAGAACAC	0.343													A	5804609	A	A	5804609	4	1	193	1	0	0	0	0	0	1	0	0	1596	1362	47	3	7355	3	C10orf18	10	5804609	Nonsense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08		5804609	129730138	45	13693											
MYO3A	53904	broad.mit.edu	37	chr10	26414537	26414537	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaagcatgactcatcaccaaGgtaaaaatttttacagaaac	6	8	2	2	rs141374777		TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr10:26414537G>T	uc001isn.2	+	19	2474	c.2114G>T	c.(2113-2115)AGT>ATT	p.S705I	MYO3A_uc009xko.1_Missense_Mutation_p.S705I|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	705	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TCATCACCAAGGTAAAAATTT	0.338													T	26414537	T	T	26414537	3	4	193	1	0	0	0	0	1	0	0	0	10076	1014	35	5	2180	5	MYO3A	10	26414537	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	20609928	26414537	109120210	46	13694											
MPP7	143098	broad.mit.edu	37	chr10	28378639	28378639	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatttttcattagtttgtcGccgatacggtgtcacttctt	8	8	3	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr10:28378639G>A	uc001iua.1	-	14	1488	c.1084C>T	c.(1084-1086)CGA>TGA	p.R362*	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Nonsense_Mutation_p.R362*|MPP7_uc009xla.2_Nonsense_Mutation_p.R362*|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	362					establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TTAGTTTGTCGCCGATACGGT	0.383													A	28378639	A	A	28378639	4	1	193	1	0	0	0	0	0	1	0	0	9739	1095	38	1	670	1	MPP7	10	28378639	Nonsense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	1964102	28378639	107156108	47	13695											
RUFY2	55680	broad.mit.edu	37	chr10	70139220	70139220	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggctgcagtaattttattgGttttttcttctagtcgggca	10	6	2	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr10:70139220G>T	uc001job.2	-	12	1598	c.1271C>A	c.(1270-1272)ACC>AAC	p.T424N	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joa.2_5'Flank|RUFY2_uc001joc.2_Missense_Mutation_p.T355N|RUFY2_uc010qiw.1_Missense_Mutation_p.T331N|RUFY2_uc001jod.1_Missense_Mutation_p.T389N	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	438	Potential.					nucleus	metal ion binding			ovary(1)	1						AATTTTATTGGTTTTTTCTTC	0.274													T	70139220	T	T	70139220	3	4	193	1	0	0	0	0	1	0	0	0	13739	1261	44	5	795	5	RUFY2	10	70139220	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	41760581	70139220	65395527	48	13696											
ZMIZ1	57178	broad.mit.edu	37	chr10	81058831	81058831	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccacaatgacgagctgcggcTcacattccctgtgcgggatg	12	13	1	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr10:81058831T>G	uc001kaf.2	+	16	2263	c.1691T>G	c.(1690-1692)CTC>CGC	p.L564R	ZMIZ1_uc001kag.2_Missense_Mutation_p.L440R	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	564					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GAGCTGCGGCTCACATTCCCT	0.647													G	81058831	G	G	81058831	3	3	193	1	0	0	0	0	1	0	0	0	17693	1551	54	5	1737	5	ZMIZ1	10	81058831	Missense_Mutation	SNP	T	TCGA-27-2521-01A-01D-1494-08	10919611	81058831	54475916	49	13697											
MAPK8IP1	9479	broad.mit.edu	37	chr11	45923593	45923593	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caggatcgggtgtctcgatcAtcctcacccctgaagacagg	11	13	3	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr11:45923593A>T	uc001nbr.2	+	4	755	c.585A>T	c.(583-585)TCA>TCT	p.S195S		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	195	JNK-binding domain (JBD).				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		TGTCTCGATCATCCTCACCCC	0.527													T	45923593	T	T	45923593	2	4	193	1	0	0	0	0	0	0	0	1	9284	204	8	5		5	MAPK8IP1	11	45923593	Silent	SNP	A	TCGA-27-2521-01A-01D-1494-08		45923593	89082923	50	13698											
DLAT	1737	broad.mit.edu	37	chr11	111899615	111899615	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acccctgctgccactgcttcGccacctacaccttctgctca	5	20	2	0	rs148153443		TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr11:111899615G>A	uc001pmo.2	+	4	1265	c.606G>A	c.(604-606)TCG>TCA	p.S202S	DLAT_uc009yyk.1_Silent_p.S202S|DLAT_uc010rwr.1_Intron	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor	202					glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	CCACTGCTTCGCCACCTACAC	0.532													A	111899615	A	A	111899615	2	1	193	1	0	0	0	0	0	0	0	1	4549	1074	38	1		1	DLAT	11	111899615	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08	65976022	111899615	23106901	51	13699											
HTR3A	3359	broad.mit.edu	37	chr11	113857602	113857602	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ataagtttggccgagaccatCttcattgtgcggctggtgca	12	9	2	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr11:113857602C>A	uc010rxb.1	+	7	1319	c.1086C>A	c.(1084-1086)ATC>ATA	p.I362I	HTR3A_uc010rxa.1_Silent_p.I330I|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Silent_p.I309I	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	324	Cytoplasmic (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	CCGAGACCATCTTCATTGTGC	0.582													A	113857602	A	A	113857602	2	1	193	1	0	0	0	0	0	0	0	1	7444	903	32	5		5	HTR3A	11	113857602	Silent	SNP	C	TCGA-27-2521-01A-01D-1494-08	1957987	113857602	21148914	52	13700			1	37		2	2	13	N	G_C	3.256105e-05
HTR3A	3359	broad.mit.edu	37	chr11	113857614	113857614	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gagaccatcttcattgtgcgGctggtgcacaagcaagacct	11	11	2	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr11:113857614G>C	uc010rxb.1	+	7	1331	c.1098G>C	c.(1096-1098)CGG>CGC	p.R366R	HTR3A_uc010rxa.1_Silent_p.R334R|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Silent_p.R313R	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	328	Cytoplasmic (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	TCATTGTGCGGCTGGTGCACA	0.572													C	113857614	C	C	113857614	2	2	193	1	0	0	0	0	0	0	0	1	7444	1190	42	5		5	HTR3A	11	113857614	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08	12	113857614	21148902	53	13701			1	37		2	2	13	N	G_C	3.256105e-05
APOA5	116519	broad.mit.edu	37	chr11	116661604	116661604	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagcccaccagctcgtgcGcctctgccatgtagggctgg	12	16	1	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr11:116661604G>A	uc001ppr.2	-	3	349	c.341C>T	c.(340-342)GCG>GTG	p.A114V	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Missense_Mutation_p.A114V|APOA5_uc009yzf.2_Missense_Mutation_p.A114V|APOA5_uc009yzg.2_Missense_Mutation_p.A140V	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	114	Potential.				acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		CAGCTCGTGCGCCTCTGCCAT	0.662													A	116661604	A	A	116661604	3	1	193	1	0	0	0	0	1	0	0	0	784	1087	38	1	763	1	APOA5	11	116661604	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	2803990	116661604	18344912	54	13702											
GRIP1	23426	broad.mit.edu	37	chr12	66786170	66786170	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggcaccgtggaggggtaCatgtcggagagcttgcctgg	18	9	0	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr12:66786170C>T	uc001stk.2	-	18	2467	c.2226G>A	c.(2224-2226)ATG>ATA	p.M742I	GRIP1_uc010sta.1_Missense_Mutation_p.M686I|GRIP1_uc001stj.2_Missense_Mutation_p.M524I|GRIP1_uc001stl.1_Missense_Mutation_p.M634I|GRIP1_uc001stm.2_Missense_Mutation_p.M742I	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	794					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TGGAGGGGTACATGTCGGAGA	0.537													T	66786170	T	T	66786170	3	4	193	1	0	0	0	0	1	0	0	0	6787	478	17	3	1032	3	GRIP1	12	66786170	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08		66786170	67065725	55	13703											
GOLGA3	2802	broad.mit.edu	37	chr12	133381337	133381337	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgagcatgctcctctgcatgTcctctaccttggccataagc	8	14	2	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr12:133381337T>A	uc001ukz.1	-	7	2121	c.1562A>T	c.(1561-1563)GAC>GTC	p.D521V	GOLGA3_uc001ula.1_Missense_Mutation_p.D521V|GOLGA3_uc001ulb.2_Missense_Mutation_p.D521V	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	521	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CCTCTGCATGTCCTCTACCTT	0.607													A	133381337	A	A	133381337	3	1	193	1	0	0	0	0	1	0	0	0	6554	1667	58	5	3144	5	GOLGA3	12	133381337	Missense_Mutation	SNP	T	TCGA-27-2521-01A-01D-1494-08	66595167	133381337	470558	56	13704											
BRCA2	675	broad.mit.edu	37	chr13	32914389	32914389	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgtagtatagggaagcttcAtaagtcagtctcatctgcaa	9	7	4	0	rs80358823		TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr13:32914389A>G	uc001uub.1	+	11	6124	c.5897A>G	c.(5896-5898)CAT>CGT	p.H1966R		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1966					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GGGAAGCTTCATAAGTCAGTC	0.358			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			G	32914389	G	G	32914389	3	3	193	1	0	0	0	0	1	0	0	0	1499	217	8	4	5935	4	BRCA2	13	32914389	Missense_Mutation	SNP	A	TCGA-27-2521-01A-01D-1494-08		32914389	82255489	57	13705											
SLITRK6	84189	broad.mit.edu	37	chr13	86370282	86370282	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taagaatttctaaagaattgTgattgatatgaagttgtttc	8	2	1	5			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr13:86370282T>G	uc001vll.1	-	2	821	c.362A>C	c.(361-363)CAC>CCC	p.H121P	SLITRK6_uc010afe.1_5'Flank	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	121	Extracellular (Potential).|LRR 2.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TAAAGAATTGTGATTGATATG	0.353													G	86370282	G	G	86370282	3	3	193	1	0	0	0	0	1	0	0	0	14747	1696	59	5	2167	5	SLITRK6	13	86370282	Missense_Mutation	SNP	T	TCGA-27-2521-01A-01D-1494-08	53455893	86370282	28799596	58	13706											
SALL2	6297	broad.mit.edu	37	chr14	21991030	21991030	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tcaagaaagccctgcctgcaGaaaacacaagtgaagagcgg	11	10	1	4			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr14:21991030G>T	uc001wbe.2	-	2	3114	c.2832C>A	c.(2830-2832)TTC>TTA	p.F944L	SALL2_uc010tly.1_Missense_Mutation_p.F942L|SALL2_uc010tlz.1_Missense_Mutation_p.F807L|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Missense_Mutation_p.F809L|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	944	C2H2-type 7.						DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CCTGCCTGCAGAAAACACAAG	0.597													T	21991030	T	T	21991030	3	4	193	1	0	0	0	0	1	0	0	0	13811	933	33	5	195	5	SALL2	14	21991030	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08		21991030	85358510	59	13707											
ACIN1	22985	broad.mit.edu	37	chr14	23531439	23531439	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggactggggccatttgacccCgtgcagagctgtgcgggtgg	18	10	0	2	rs138390500	byFrequency	TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr14:23531439C>T	uc001wit.3	-	16	3539	c.3211G>A	c.(3211-3213)GGG>AGG	p.G1071R	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.G313R|ACIN1_uc001wiq.3_Missense_Mutation_p.G313R|ACIN1_uc001wir.3_Missense_Mutation_p.G344R|ACIN1_uc001wis.3_Missense_Mutation_p.G752R|ACIN1_uc010akg.2_Missense_Mutation_p.G1058R	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1071					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CATTTGACCCCGTGCAGAGCT	0.552													T	23531439	T	T	23531439	3	4	193	1	0	0	0	0	1	0	0	0	142	652	23	2	830	2	ACIN1	14	23531439	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	1540409	23531439	83818101	60	13708											
SECISBP2L	9728	broad.mit.edu	37	chr15	49325161	49325161	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atgtaagaacccttgccttaCcagtttgctgtgaagcatct	8	10	1	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr15:49325161C>G	uc001zxe.1	-	4	798	c.664_splice	c.e4+1	p.D222_splice	SECISBP2L_uc001zxd.1_Splice_Site_p.D222_splice|SECISBP2L_uc010bep.1_Splice_Site|SECISBP2L_uc010beq.1_Intron	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like											breast(1)|skin(1)	2						CCTTGCCTTACCAGTTTGCTG	0.393													G	49325161	G	G	49325161	5	3	193	1	0	0	0	0	0	0	1	0	14007	521	18	5	2561	5	SECISBP2L	15	49325161	Splice_Site	SNP	C	TCGA-27-2521-01A-01D-1494-08		49325161	53206231	61	13709			2	38		2	2	20	C		5.15545e-05
SECISBP2L	9728	broad.mit.edu	37	chr15	49325180	49325180	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	accagtttgctgtgaagcatCtaccagaagcacaatttttg	8	9	1	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr15:49325180C>G	uc001zxe.1	-	4	780	c.646G>C	c.(646-648)GAT>CAT	p.D216H	SECISBP2L_uc001zxd.1_Missense_Mutation_p.D216H|SECISBP2L_uc010bep.1_5'UTR|SECISBP2L_uc010beq.1_Intron	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	216										breast(1)|skin(1)	2						TGTGAAGCATCTACCAGAAGC	0.398													G	49325180	G	G	49325180	3	3	193	1	0	0	0	0	1	0	0	0	14007	913	32	5	2580	5	SECISBP2L	15	49325180	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	19	49325180	53206212	62	13710			2	38		2	2	20	C		5.15545e-05
FBXO22	26263	broad.mit.edu	37	chr15	76225151	76225151	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gactgctgaggctgcgatgcAgcgcctcaaagcggccaaca	13	13	1	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr15:76225151A>G	uc002bbk.2	+	7	1025	c.920A>G	c.(919-921)CAG>CGG	p.Q307R	FBXO22_uc002bbl.2_Missense_Mutation_p.Q203R|FBXO22OS_uc002bbm.1_RNA	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	F-box only protein 22 isoform a	307					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity				0						GCTGCGATGCAGCGCCTCAAA	0.527													G	76225151	G	G	76225151	3	3	193	1	0	0	0	0	1	0	0	0	5734	188	7	4	983	4	FBXO22	15	76225151	Missense_Mutation	SNP	A	TCGA-27-2521-01A-01D-1494-08	26899971	76225151	26306241	63	13711											
TSC2	7249	broad.mit.edu	37	chr16	2138318	2138318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgccacatcaagcggctcCgccagcgggtagggaatatg	13	13	1	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr16:2138318C>T	uc002con.2	+	41	5357	c.5251C>T	c.(5251-5253)CGC>TGC	p.R1751C	TSC2_uc010bsd.2_Missense_Mutation_p.R1728C|TSC2_uc002coo.2_Missense_Mutation_p.R1684C|TSC2_uc010uvv.1_Missense_Mutation_p.R1648C|TSC2_uc010uvw.1_Missense_Mutation_p.R1636C|TSC2_uc002cop.2_Missense_Mutation_p.R1507C|TSC2_uc002coq.2_Missense_Mutation_p.R526C|TSC2_uc002cor.2_Missense_Mutation_p.R452C	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1751	Rap-GAP.		Missing (in TSC2).	RLR->QLQ: No effect.	cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CAAGCGGCTCCGCCAGCGGGT	0.662			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				T	2138318	T	T	2138318	3	4	193	1	0	0	0	0	1	0	0	0	16603	652	23	2	5409	2	TSC2	16	2138318	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08		2138318	88216435	64	13712											
RRAD	6236	broad.mit.edu	37	chr16	66957423	66957424	+	Missense_Mutation	DNP	CA	AC	AC													cctgccgcctactcaccatcCaccgagacctcacgagagcg							TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr16:66957423_66957424CA>AC	uc002eqn.2	-	4	796_797	c.644_645TG>GT	c.(643-645)GTG>GGT	p.V215G	RRAD_uc002eqo.2_Missense_Mutation_p.V215G	NM_001128850	NP_001122322	P55042	RAD_HUMAN	Ras-related associated with diabetes	215					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		ACTCACCATCCACCGAGACCTC	0.634													AC	66957424	AC	AC	66957423	3	1	193	1	0	0	0	0	1	0	0	0	13671	581	21	5	289	5	RRAD	16	66957423	Missense_Mutation	DNP	CA	TCGA-27-2521-01A-01D-1494-08	64819105	66957423	23397330	65	13713											
ACADVL	37	broad.mit.edu	37	chr17	7125285	7125285	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacaggggagactgtggccGctttctgtctaaccgagccc	12	13	2	1	rs140629318		TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr17:7125285G>A	uc002gev.2	+	8	788	c.637G>A	c.(637-639)GCT>ACT	p.A213T	DLG4_uc002get.3_5'Flank|DLG4_uc010vto.1_5'Flank|ACADVL_uc010vtp.1_Missense_Mutation_p.A223T|ACADVL_uc010vtq.1_Missense_Mutation_p.A259T|ACADVL_uc002gew.2_Missense_Mutation_p.A191T|ACADVL_uc002gex.2_Missense_Mutation_p.A137T	NM_000018	NP_000009	P49748	ACADV_HUMAN	acyl-Coenzyme A dehydrogenase, very long chain	213	Catalytic.		A -> P (in ACADVLD).		energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial inner membrane|mitochondrial nucleoid	long-chain-acyl-CoA dehydrogenase activity			ovary(3)	3						GACTGTGGCCGCTTTCTGTCT	0.572													A	7125285	A	A	7125285	3	1	193	1	0	0	0	0	1	0	0	0	116	1087	38	1	667	1	ACADVL	17	7125285	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08		7125285	74069925	66	13714											
TP53	7157	broad.mit.edu	37	chr17	7577149	7577149	+	Frame_Shift_Del	DEL	A	-	-													aagctgttccgtcccagtagAttaccactactcaggatagg							TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr17:7577149delA	uc002gim.2	-	8	983	c.789delT	c.(787-789)AATfs	p.N263fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Del_p.N263fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.N131fs|TP53_uc010cng.1_Frame_Shift_Del_p.N131fs|TP53_uc002gii.1_Frame_Shift_Del_p.N131fs|TP53_uc010cnh.1_Frame_Shift_Del_p.N263fs|TP53_uc010cni.1_Frame_Shift_Del_p.N263fs|TP53_uc002gij.2_Frame_Shift_Del_p.N263fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	263	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		GN -> PD (in a sporadic cancer; somatic mutation).|N -> S (in a sporadic cancer; somatic mutation).|N -> K (in a sporadic cancer; somatic mutation).|N -> D (in sporadic cancers; somatic mutation).|N -> H (in sporadic cancers; somatic mutation).|N -> I (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.N263fs*82(3)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.N263D(2)|p.N263I(2)|p.G262_S269delGNLLGRNS(2)|p.N263H(2)|p.E258fs*71(1)|p.S261_L264>R(1)|p.N263fs*84(1)|p.N263K(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCCCAGTAGATTACCACTAC	0.517		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			-	7577149	-	-	7577149	7	5	193	1	0	1	0	1	0	0	0	0	16378	330	12	0	497	0	TP53	17	7577149	Frame_Shift_Del	DEL	A	TCGA-27-2521-01A-01D-1494-08	451864	7577149	73618061	67	13715											
SLC13A2	9058	broad.mit.edu	37	chr17	26823547	26823547	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctggccttcatgttgcctgTggccaccccgcccaatgcca	9	18	1	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr17:26823547T>C	uc002hbh.2	+	11	1617	c.1550T>C	c.(1549-1551)GTG>GCG	p.V517A	SLC13A2_uc010wam.1_Missense_Mutation_p.V473A|SLC13A2_uc010wan.1_Missense_Mutation_p.V566A|SLC13A2_uc010wao.1_Missense_Mutation_p.V474A|SLC13A2_uc002hbi.2_Missense_Mutation_p.V446A	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	517	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	ATGTTGCCTGTGGCCACCCCG	0.617													C	26823547	C	C	26823547	3	2	193	1	0	0	0	0	1	0	0	0	14392	1696	59	4	1739	4	SLC13A2	17	26823547	Missense_Mutation	SNP	T	TCGA-27-2521-01A-01D-1494-08	19246398	26823547	54371663	68	13716											
MYO18A	399687	broad.mit.edu	37	chr17	27424842	27424842	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacttccccgttgatctccgCtgcccggatgagacgggcct	11	16	1	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr17:27424842C>T	uc002hdt.1	-	26	4224	c.4066G>A	c.(4066-4068)GCG>ACG	p.A1356T	MYO18A_uc010wbc.1_Missense_Mutation_p.A898T|MYO18A_uc002hds.2_Missense_Mutation_p.A898T|MYO18A_uc010csa.1_Missense_Mutation_p.A1356T|MYO18A_uc002hdu.1_Missense_Mutation_p.A1356T|MYO18A_uc010wbd.1_Missense_Mutation_p.A1025T	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1356	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TTGATCTCCGCTGCCCGGATG	0.602													T	27424842	T	T	27424842	3	4	193	1	0	0	0	0	1	0	0	0	10065	797	28	3	2166	3	MYO18A	17	27424842	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	601295	27424842	53770368	69	13717											
SUZ12	23512	broad.mit.edu	37	chr17	30320320	30320320	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aagaaaaggatactccaaatGaaaaccgacaaaaattaaga	6	6	0	3			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr17:30320320G>A	uc002hgs.2	+	11	1483	c.1261G>A	c.(1261-1263)GAA>AAA	p.E421K	SUZ12_uc002hgt.2_Missense_Mutation_p.E398K	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	421					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				TACTCCAAATGAAAACCGACA	0.264			T	JAZF1	endometrial stromal tumours								A	30320320	A	A	30320320	3	1	193	1	0	0	0	0	1	0	0	0	15413	1291	45	3	1303	3	SUZ12	17	30320320	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	2895478	30320320	50874890	70	13718											
GNGT2	2793	broad.mit.edu	37	chr17	47284162	47284162	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctccttgaagggattcttgTcctcagggatgcctttgaga	11	9	3	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr17:47284162T>C	uc002ioo.1	-	4	474	c.167A>G	c.(166-168)GAC>GGC	p.D56G		NM_031498	NP_113686	O14610	GBGT2_HUMAN	guanine nucleotide binding protein-gamma	56					G-protein coupled receptor protein signaling pathway|phototransduction|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			GGGATTCTTGTCCTCAGGGAT	0.507													C	47284162	C	C	47284162	3	2	193	1	0	0	0	0	1	0	0	0	6534	1667	58	4	46	4	GNGT2	17	47284162	Missense_Mutation	SNP	T	TCGA-27-2521-01A-01D-1494-08	16963842	47284162	33911048	71	13719											
WIPI1	55062	broad.mit.edu	37	chr17	66417949	66417949	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgcccttctgatttccacGgcacaagattatctaccaaa	5	12	2	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr17:66417949G>A	uc010dey.2	-	13	1397	c.1306C>T	c.(1306-1308)CGT>TGT	p.R436C	WIPI1_uc002jhd.3_RNA|WIPI1_uc010wqo.1_Missense_Mutation_p.R354C|WIPI1_uc002jhe.3_RNA	NM_017983	NP_060453	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting	436					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding				0						TGATTTCCACGGCACAAGATT	0.468													A	66417949	A	A	66417949	3	1	193	1	0	0	0	0	1	0	0	0	17367	1116	39	2	38	2	WIPI1	17	66417949	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	19133787	66417949	14777261	72	13720											
CLUL1	27098	broad.mit.edu	37	chr18	633305	633305	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgttccctgtagctcctgaCcacggaggcctgatttcaaa	9	12	1	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr18:633305C>A	uc002kkp.2	+	6	1009	c.864C>A	c.(862-864)GAC>GAA	p.D288E	CLUL1_uc010wys.1_Missense_Mutation_p.D340E|CLUL1_uc002kkq.2_Missense_Mutation_p.D288E	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	288					cell death	extracellular region				ovary(2)	2						TAGCTCCTGACCACGGAGGCC	0.428													A	633305	A	A	633305	3	1	193	1	0	0	0	0	1	0	0	0	3570	506	18	5	882	5	CLUL1	18	633305	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08		633305	77443943	73	13721											
TCEB3C	162699	broad.mit.edu	37	chr18	44554624	44554624	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaattgccttggccatcagCggggccactttcttggcagc	12	13	2	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr18:44554624C>T	uc010xdb.1	-	1	1826	c.1590G>A	c.(1588-1590)CCG>CCA	p.P530P	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	530					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						TGGCCATCAGCGGGGCCACTT	0.368													T	44554624	T	T	44554624	2	4	193	1	0	0	0	0	0	0	0	1	15680	755	27	1		1	TCEB3C	18	44554624	Silent	SNP	C	TCGA-27-2521-01A-01D-1494-08	43921319	44554624	33522624	74	13722											
SLC39A3	29985	broad.mit.edu	37	chr19	2733097	2733097	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acggccacccccacgaacagGctcaccactttctccccctc	5	22	2	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr19:2733097G>A	uc002lwg.2	-	3	851	c.597C>T	c.(595-597)AGC>AGT	p.S199S	SLC39A3_uc010xgy.1_Silent_p.S199S	NM_144564	NP_653165	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter),	199	Helical; (Potential).					integral to membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACGAACAGGCTCACCACTT	0.716													A	2733097	A	A	2733097	2	1	193	1	0	0	0	0	0	0	0	1	14619	1194	42	3		3	SLC39A3	19	2733097	Silent	SNP	G	TCGA-27-2521-01A-01D-1494-08		2733097	56395886	75	13723											
OR2Z1	284383	broad.mit.edu	37	chr19	8841547	8841547	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcttcttgatccgtgtggacTcccggctccatacacccatg	8	15	2	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr19:8841547T>C	uc010xkg.1	+	1	157	c.157T>C	c.(157-159)TCC>CCC	p.S53P		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						CCGTGTGGACTCCCGGCTCCA	0.542													C	8841547	C	C	8841547	3	2	193	1	0	0	0	0	1	0	0	0	11036	1551	54	4	159	4	OR2Z1	19	8841547	Missense_Mutation	SNP	T	TCGA-27-2521-01A-01D-1494-08	6108450	8841547	50287436	76	13724											
CIC	23152	broad.mit.edu	37	chr19	42795881	42795881	+	Frame_Shift_Del	DEL	C	-	-													agtacctgtgcagaatggtgCccagccccccagcaaggtga							TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr19:42795881delC	uc002otf.1	+	11	2910	c.2870delC	c.(2869-2871)GCCfs	p.A957fs		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	957	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CAGAATGGTGCCCAGCCCCCC	0.602			T	DUX4	soft tissue sarcoma								-	42795881	-	-	42795881	7	5	193	1	0	1	0	1	0	0	0	0	3424	739	26	0	2912	0	CIC	19	42795881	Frame_Shift_Del	DEL	C	TCGA-27-2521-01A-01D-1494-08	33954334	42795881	16333102	77	13725											
GPR4	2828	broad.mit.edu	37	chr19	46094298	46094298	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtccgccacacagttgaggCtggtgaaagccagtgagctg	15	10	0	3			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr19:46094298C>T	uc002pcm.2	-	2	1772	c.827G>A	c.(826-828)AGC>AAC	p.S276N	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	276	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		ACAGTTGAGGCTGGTGAAAGC	0.647													T	46094298	T	T	46094298	3	4	193	1	0	0	0	0	1	0	0	0	6694	797	28	3	265	3	GPR4	19	46094298	Missense_Mutation	SNP	C	TCGA-27-2521-01A-01D-1494-08	3298417	46094298	13034685	78	13726											
ZNF71	58491	broad.mit.edu	37	chr19	57132720	57132721	+	Frame_Shift_Ins	INS	-	G	G													tccgttgttggggaggccacINSggggggacccacgaggaatg							TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr19:57132720_57132721insG	uc002qnm.3	+	3	303_304	c.65_66insG	c.(64-66)ACGfs	p.T22fs		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	22						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GGGGAGGCCACGGGGGGACCCA	0.554													G	57132721	G	G	57132720	7	5	193	1	0	1	1	0	0	0	0	0	18111	536	19	0	67	0	ZNF71	19	57132720	Frame_Shift_Ins	INS	-	TCGA-27-2521-01A-01D-1494-08	11038422	57132720	1996263	79	13727											
SPTLC3	55304	broad.mit.edu	37	chr20	13052999	13052999	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaccggcccatctgcagtgcCccagggcctctgtttgattt	10	14	2	1			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr20:13052999C>G	uc002wod.1	+	3	688	c.399C>G	c.(397-399)GCC>GCG	p.A133A		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	133					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	TCTGCAGTGCCCCAGGGCCTC	0.438													G	13052999	G	G	13052999	2	3	193	1	0	0	0	0	0	0	0	1	15124	610	22	5		5	SPTLC3	20	13052999	Silent	SNP	C	TCGA-27-2521-01A-01D-1494-08		13052999	49972521	80	13728											
ZNF831	128611	broad.mit.edu	37	chr20	57829379	57829379	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagtcacagaagagggcagaGcacagaccctcttgccaggg	13	11	2	4			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chr20:57829379G>A	uc002yan.2	+	5	4615	c.4615G>A	c.(4615-4617)GCA>ACA	p.A1539T		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1539						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGAGGGCAGAGCACAGACCCT	0.498													A	57829379	A	A	57829379	3	1	193	1	0	0	0	0	1	0	0	0	18182	971	34	3	4633	3	ZNF831	20	57829379	Missense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	44776380	57829379	5196141	81	13729											
MAGEB16	139604	broad.mit.edu	37	chrX	35820799	35820799	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgagagcttctgagcacctAgagatgatatttggccttga	11	8	1	5			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chrX:35820799A>G	uc010ngt.1	+	2	765	c.486A>G	c.(484-486)CTA>CTG	p.L162L		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	162	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						CTGAGCACCTAGAGATGATAT	0.468													G	35820799	G	G	35820799	2	3	193	1	0	0	0	0	0	0	0	1	9174	407	15	4		4	MAGEB16	23	35820799	Silent	SNP	A	TCGA-27-2521-01A-01D-1494-08		35820799	119449761	82	13730											
WDR13	64743	broad.mit.edu	37	chrX	48458765	48458765	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggcctgctgctcactcgaCggcagcatctccctgtgcca	10	17	2	0			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chrX:48458765C>T	uc004dkh.1	+	6	729	c.582C>T	c.(580-582)GAC>GAT	p.D194D	WDR13_uc010nif.1_Silent_p.D72D|WDR13_uc004dki.1_Silent_p.D102D|WDR13_uc004dkj.1_Silent_p.D194D|WDR13_uc004dkk.1_Silent_p.D102D|WDR13_uc004dkl.3_Silent_p.D102D|WDR13_uc011mme.1_Silent_p.D72D	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	194	WD 1.					cytoplasm|nucleus				ovary(2)	2						GCTCACTCGACGGCAGCATCT	0.632													T	48458765	T	T	48458765	2	4	193	1	0	0	0	0	0	0	0	1	17272	535	19	1		1	WDR13	23	48458765	Silent	SNP	C	TCGA-27-2521-01A-01D-1494-08	12637966	48458765	106811795	83	13731											
ATRX	546	broad.mit.edu	37	chrX	76875916	76875916	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttaaaataatcctcctccttGatcgtatagaattcatagct	4	9	1	2			TCGA-27-2521-01A-01D-1494-08	TCGA-27-2521-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	3678d5f3-9a29-4750-b0a9-20e971ff6aa4	04c01b52-cf2f-4432-a541-c20085c3db62	g.chrX:76875916G>C	uc004ecp.3	-	20	5451	c.5219C>G	c.(5218-5220)TCA>TGA	p.S1740*	ATRX_uc004ecq.3_Nonsense_Mutation_p.S1702*|ATRX_uc004eco.3_Nonsense_Mutation_p.S1525*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1740	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CCTCCTCCTTGATCGTATAGA	0.333			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						C	76875916	C	C	76875916	4	2	193	1	0	0	0	0	0	1	0	0	1208	1294	45	5	2323	5	ATRX	23	76875916	Nonsense_Mutation	SNP	G	TCGA-27-2521-01A-01D-1494-08	28417151	76875916	78394644	84	13732											
HRNR	388697	broad.mit.edu	37	chr1	152187663	152187663	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgagctagatccgtgtcGttcacccctagatgactgtc	9	13	1	4			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:152187663G>A	uc001ezt.1	-	3	6518	c.6442C>T	c.(6442-6444)CGA>TGA	p.R2148*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2148					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATCCGTGTCGTTCACCCCTA	0.587													A	152187663	A	A	152187663	4	1	194	1	0	0	0	0	0	1	0	0	7359	1153	40	1	2114	1	HRNR	1	152187663	Nonsense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08		152187663	97062958	1	13733											
MEF2D	4209	broad.mit.edu	37	chr1	156446904	156446904	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgtgggtaggtgggggtGgagacttggcagggatgacc	21	5	0	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:156446904G>A	uc001fpc.2	-	7	1145	c.755C>T	c.(754-756)CCG>CTG	p.P252L	MEF2D_uc001fpb.2_Missense_Mutation_p.P252L|MEF2D_uc001fpd.2_Missense_Mutation_p.P252L|MEF2D_uc001fpe.1_Missense_Mutation_p.P252L|MEF2D_uc009wsa.2_RNA	NM_005920	NP_005911	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	252	Poly-Pro.				apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGTGGGGGTGGAGACTTGGC	0.607													A	156446904	A	A	156446904	3	1	194	1	0	0	0	0	1	0	0	0	9458	1348	47	3	834	3	MEF2D	1	156446904	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	4259241	156446904	92803717	2	13734											
FCER1A	2205	broad.mit.edu	37	chr1	159275846	159275846	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctcttcctcaggtgccatGgttggaggaactgggatgtg	14	10	2	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:159275846G>A	uc001ftq.2	+	5	499	c.400G>A	c.(400-402)GGT>AGT	p.G134S		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	134	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CAGGTGCCATGGTTGGAGGAA	0.468													A	159275846	A	A	159275846	3	1	194	1	0	0	0	0	1	0	0	0	5774	1348	47	3	414	3	FCER1A	1	159275846	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	2828942	159275846	89974775	3	13735											
DUSP27	92235	broad.mit.edu	37	chr1	167097485	167097485	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgagaggagagcccagagccCtacttcttccgccggacccc	11	17	1	3			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:167097485C>A	uc001geb.1	+	5	3117	c.3117C>A	c.(3115-3117)CCC>CCA	p.P1039P		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1039					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GCCCAGAGCCCTACTTCTTCC	0.587													A	167097485	A	A	167097485	2	1	194	1	0	0	0	0	0	0	0	1	4824	668	24	5		5	DUSP27	1	167097485	Silent	SNP	C	TCGA-27-2523-01A-01D-1494-08	7821639	167097485	82153136	4	13736											
HMCN1	83872	broad.mit.edu	37	chr1	185878633	185878633	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccaatgattgaaattcgcaaTcctttaggtgagatatatca	7	7	1	3			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:185878633T>A	uc001grq.1	+	5	1015	c.786T>A	c.(784-786)AAT>AAA	p.N262K		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	262					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AAATTCGCAATCCTTTAGGTG	0.363													A	185878633	A	A	185878633	3	1	194	1	0	0	0	0	1	0	0	0	7220	1432	50	5	804	5	HMCN1	1	185878633	Missense_Mutation	SNP	T	TCGA-27-2523-01A-01D-1494-08	18781148	185878633	63371988	5	13737											
LAMB3	3914	broad.mit.edu	37	chr1	209790792	209790792	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgctcgctggcaccttccGcaagctgctgggcctggact	12	16	0	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:209790792G>A	uc001hhg.2	-	20	3581	c.3191C>T	c.(3190-3192)GCG>GTG	p.A1064V	LAMB3_uc009xco.2_Missense_Mutation_p.A1064V|LAMB3_uc001hhh.2_Missense_Mutation_p.A1064V	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1064	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGCACCTTCCGCAAGCTGCTG	0.627													A	209790792	A	A	209790792	3	1	194	1	0	0	0	0	1	0	0	0	8612	1087	38	1	339	1	LAMB3	1	209790792	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	23912159	209790792	39459829	6	13738											
LAMB3	3914	broad.mit.edu	37	chr1	209801465	209801465	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tctccctgcacatgctccttGcacacacactgcccggtcac	6	19	2	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:209801465G>C	uc001hhg.2	-	10	1593	c.1203C>G	c.(1201-1203)TGC>TGG	p.C401W	LAMB3_uc009xco.2_Missense_Mutation_p.C401W|LAMB3_uc001hhh.2_Missense_Mutation_p.C401W|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	401	Laminin EGF-like 3.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CATGCTCCTTGCACACACACT	0.642											OREG0014217	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	209801465	C	C	209801465	3	2	194	1	0	0	0	0	1	0	0	0	8612	1311	46	5	2367	5	LAMB3	1	209801465	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	10673	209801465	39449156	7	13739											
C1orf107	27042	broad.mit.edu	37	chr1	210001468	210001468	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aacaccctaactaaaaagcaGaagaaacatcttcgagattt	5	9	1	3			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:210001468G>C	uc001hhr.1	+	1	136	c.60G>C	c.(58-60)CAG>CAC	p.Q20H	C1orf107_uc009xcu.1_5'UTR	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	20					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		CTAAAAAGCAGAAGAAACATC	0.547											OREG0014221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	210001468	C	C	210001468	3	2	194	1	0	0	0	0	1	0	0	0	1981	933	33	5	62	5	C1orf107	1	210001468	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	200003	210001468	39249153	8	13740			1	39		2	2	26	G		5.249123e-05
C1orf107	27042	broad.mit.edu	37	chr1	210001493	210001493	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aacatcttcgagatttcggcGaggagcatcccttctatgac	9	11	2	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:210001493G>T	uc001hhr.1	+	1	161	c.85G>T	c.(85-87)GAG>TAG	p.E29*	C1orf107_uc009xcu.1_5'UTR	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	29					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		AGATTTCGGCGAGGAGCATCC	0.547											OREG0014221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	210001493	T	T	210001493	4	4	194	1	0	0	0	0	0	1	0	0	1981	1059	37	5	87	5	C1orf107	1	210001493	Nonsense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	25	210001493	39249128	9	13741			1	39		2	2	26	G		5.249123e-05
PGBD2	267002	broad.mit.edu	37	chr1	249212387	249212387	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgacacaacatctcaagGgaggcgaagcaggcggttgg	15	9	1	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:249212387G>A	uc001ifh.2	+	3	1751	c.1604G>A	c.(1603-1605)GGG>GAG	p.G535E	PGBD2_uc001ifg.2_Missense_Mutation_p.G284E|PGBD2_uc009xhd.2_Missense_Mutation_p.G532E	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	535										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ACATCTCAAGGGAGGCGAAGC	0.547													A	249212387	A	A	249212387	3	1	194	1	0	0	0	0	1	0	0	0	11781	1232	43	3	1610	3	PGBD2	1	249212387	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	39210894	249212387	38234	10	13742											
PGBD2	267002	broad.mit.edu	37	chr1	249212544	249212544	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtccatgccaaatgcttcagGgagtaccacatccggtgaca	10	12	1	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr1:249212544G>T	uc001ifh.2	+	3	1908	c.1761G>T	c.(1759-1761)AGG>AGT	p.R587S	PGBD2_uc001ifg.2_Missense_Mutation_p.R336S|PGBD2_uc009xhd.2_Missense_Mutation_p.R584S	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	587										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AATGCTTCAGGGAGTACCACA	0.478													T	249212544	T	T	249212544	3	4	194	1	0	0	0	0	1	0	0	0	11781	1223	43	5	1767	5	PGBD2	1	249212544	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	157	249212544	38077	11	13743											
HK2	3099	broad.mit.edu	37	chr2	75081480	75081480	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctcttggagatctctaagCggttccgcaaggagatggag	13	10	2	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr2:75081480C>T	uc002snd.2	+	2	2050	c.124C>T	c.(124-126)CGG>TGG	p.R42W		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	42	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GATCTCTAAGCGGTTCCGCAA	0.512													T	75081480	T	T	75081480	3	4	194	1	0	0	0	0	1	0	0	0	7191	759	27	1	130	1	HK2	2	75081480	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08		75081480	168117893	12	13744											
UGGT1	56886	broad.mit.edu	37	chr2	128944331	128944331	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctttggtgtgaaacgtgGtgtgatgacgcctctaagaa	14	6	1	4			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr2:128944331G>A	uc002tps.2	+	39	4612	c.4434G>A	c.(4432-4434)TGG>TGA	p.W1478*	UGGT1_uc002tpr.2_Nonsense_Mutation_p.W1454*	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1478	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						GTGAAACGTGGTGTGATGACG	0.413													A	128944331	A	A	128944331	4	1	194	1	0	0	0	0	0	1	0	0	16938	1270	44	3	4588	3	UGGT1	2	128944331	Nonsense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	53862851	128944331	114255042	13	13745											
TTN	7273	broad.mit.edu	37	chr2	179571370	179571370	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttttggtggatgaaaacaCgacctccttggttcagctgt	10	9	1	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr2:179571370C>T	uc010zfg.1	-	99	25723	c.25499G>A	c.(25498-25500)CGT>CAT	p.R8500H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R5161H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9427							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGAAAACACGACCTCCTTG	0.443													T	179571370	T	T	179571370	3	4	194	1	0	0	0	0	1	0	0	0	16732	536	19	1	75342	1	TTN	2	179571370	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	50627039	179571370	63628003	14	13746											
AQP12B	653437	broad.mit.edu	37	chr2	241621969	241621969	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggaactcctgcagggacaCggtggggttggccgaggccc	18	11	0	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr2:241621969C>T	uc010fzj.2	-	1	349	c.286G>A	c.(286-288)GTG>ATG	p.V96M	AQP12B_uc002vzt.2_Intron	NM_001102467	NP_001095937	A6NM10	AQ12B_HUMAN	aquaporin 12B	84						integral to membrane	transporter activity				0		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		TGCAGGGACACGGTGGGGTTG	0.687													T	241621969	T	T	241621969	3	4	194	1	0	0	0	0	1	0	0	0	825	536	19	1	649	1	AQP12B	2	241621969	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	62050599	241621969	1577404	15	13747											
DCLK3	85443	broad.mit.edu	37	chr3	36779774	36779774	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtcttttcaatctccaccCcaagatgcttctctcccctt	4	16	4	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr3:36779774C>T	uc003cgi.2	-	2	868	c.377G>A	c.(376-378)GGG>GAG	p.G126E		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	126						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						AATCTCCACCCCAAGATGCTT	0.567													T	36779774	T	T	36779774	3	4	194	1	0	0	0	0	1	0	0	0	4293	623	22	3	1585	3	DCLK3	3	36779774	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08		36779774	161242656	16	13748											
SLC6A20	54716	broad.mit.edu	37	chr3	45801400	45801400	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccccgtgaggatgtagtcGctcaggtagaagacaaagag	14	8	1	4	rs143985135		TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr3:45801400G>A	uc011bai.1	-	10	1702	c.1578C>T	c.(1576-1578)AGC>AGT	p.S526S	SLC6A20_uc003cow.2_Silent_p.S176S|SLC6A20_uc011baj.1_Silent_p.S489S	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	526	Extracellular (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		GGATGTAGTCGCTCAGGTAGA	0.592													A	45801400	A	A	45801400	2	1	194	1	0	0	0	0	0	0	0	1	14684	1078	38	1		1	SLC6A20	3	45801400	Silent	SNP	G	TCGA-27-2523-01A-01D-1494-08	9021626	45801400	152221030	17	13749											
NIT2	56954	broad.mit.edu	37	chr3	100057936	100057936	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtctttgttctcagctttcCgcttggccctcatccagctt	7	14	3	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr3:100057936C>T	uc003dtv.2	+	2	87	c.13C>T	c.(13-15)CGC>TGC	p.R5C	NIT2_uc011bha.1_Missense_Mutation_p.R5C	NM_020202	NP_064587	Q9NQR4	NIT2_HUMAN	nitrilase family, member 2	5	CN hydrolase.				nitrogen compound metabolic process		omega-amidase activity			ovary(1)	1						CTCAGCTTTCCGCTTGGCCCT	0.403													T	100057936	T	T	100057936	3	4	194	1	0	0	0	0	1	0	0	0	10434	652	23	2	19	2	NIT2	3	100057936	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	54256536	100057936	97964494	18	13750											
DLG1	1739	broad.mit.edu	37	chr3	196921382	196921382	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctctgagacatgaaccaattCtggacctatcacttcatttg	6	11	4	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr3:196921382C>G	uc003fxo.3	-	5	587	c.397G>C	c.(397-399)GAA>CAA	p.E133Q	DLG1_uc011bud.1_5'UTR|DLG1_uc003fxn.3_Missense_Mutation_p.E133Q|DLG1_uc011bue.1_Missense_Mutation_p.E133Q|DLG1_uc010ial.2_Missense_Mutation_p.E133Q|DLG1_uc011buf.1_RNA|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Missense_Mutation_p.E133Q	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	133					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TGAACCAATTCTGGACCTATC	0.353													G	196921382	G	G	196921382	3	3	194	1	0	0	0	0	1	0	0	0	4554	922	32	5	2509	5	DLG1	3	196921382	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	96863446	196921382	1101048	19	13751											
SLIT2	9353	broad.mit.edu	37	chr4	20543202	20543202	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacttcctgaaagaaataccCatccaggatgtggccattca	7	11	1	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr4:20543202C>T	uc003gpr.1	+	20	2307	c.2103C>T	c.(2101-2103)CCC>CCT	p.P701P	SLIT2_uc003gps.1_Silent_p.P693P	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	701	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AAGAAATACCCATCCAGGATG	0.443													T	20543202	T	T	20543202	2	4	194	1	0	0	0	0	0	0	0	1	14740	581	21	3		3	SLIT2	4	20543202	Silent	SNP	C	TCGA-27-2523-01A-01D-1494-08		20543202	170611074	20	13752											
N4BP2	55728	broad.mit.edu	37	chr4	40119548	40119548	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgttggaacattatcaacGttttgtttcagtgccaataa	7	6	2	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr4:40119548G>A	uc003guy.3	+	8	2062	c.1724G>A	c.(1723-1725)CGT>CAT	p.R575H	N4BP2_uc010ifq.2_Missense_Mutation_p.R495H|N4BP2_uc010ifr.2_Missense_Mutation_p.R495H	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	575						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						CATTATCAACGTTTTGTTTCA	0.363													A	40119548	A	A	40119548	3	1	194	1	0	0	0	0	1	0	0	0	10110	1145	40	1	1746	1	N4BP2	4	40119548	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	19576346	40119548	151034728	21	13753											
PCDH10	57575	broad.mit.edu	37	chr4	134084209	134084209	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtgctggatgccttcttttGtcccttctgatggacgccag	12	11	2	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr4:134084209G>T	uc003iha.2	+	4	3701	c.2875G>T	c.(2875-2877)GTC>TTC	p.V959F		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	959	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCCTTCTTTTGTCCCTTCTGA	0.488													T	134084209	T	T	134084209	3	4	194	1	0	0	0	0	1	0	0	0	11507	1377	48	5	2949	5	PCDH10	4	134084209	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	93964661	134084209	57070067	22	13754											
DCLK2	166614	broad.mit.edu	37	chr4	151170830	151170830	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	actaccaccggggtctccgtCatcatggtgagtggaaggcg	14	11	3	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr4:151170830C>G	uc003ilm.3	+	15	2167	c.2067C>G	c.(2065-2067)GTC>GTG	p.V689V	DCLK2_uc003iln.3_Silent_p.V688V|DCLK2_uc003ilo.3_Silent_p.V706V|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	689					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					GGGTCTCCGTCATCATGGTGA	0.532													G	151170830	G	G	151170830	2	3	194	1	0	0	0	0	0	0	0	1	4292	813	29	5		5	DCLK2	4	151170830	Silent	SNP	C	TCGA-27-2523-01A-01D-1494-08	17086621	151170830	39983446	23	13755											
AP3S1	1176	broad.mit.edu	37	chr5	115177778	115177778	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacaaccacgggaagccgcGgctctccaagttctaccagc	9	16	2	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr5:115177778G>A	uc003krl.2	+	1	160	c.44G>A	c.(43-45)CGG>CAG	p.R15Q	AP3S1_uc003krk.2_5'UTR|AP3S1_uc003krm.2_Missense_Mutation_p.R15Q|ATG12_uc003krh.2_5'Flank|ATG12_uc003kri.2_5'Flank|ATG12_uc003krj.2_5'Flank	NM_001284	NP_001275	Q92572	AP3S1_HUMAN	adaptor-related protein complex 3, sigma 1	15					insulin receptor signaling pathway|intracellular protein transport|vesicle-mediated transport	AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|Golgi apparatus|transport vesicle	protein binding|protein transporter activity				0		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;1.08e-07)|Epithelial(69;1.11e-06)|all cancers(49;5.2e-05)		GGGAAGCCGCGGCTCTCCAAG	0.692													A	115177778	A	A	115177778	3	1	194	1	0	0	0	0	1	0	0	0	749	1116	39	2	46	2	AP3S1	5	115177778	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08		115177778	65737482	24	13756											
DOCK2	1794	broad.mit.edu	37	chr5	169506008	169506008	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaattagcatcacccaagaCgccgagagtggagcaggagg	15	9	1	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr5:169506008C>T	uc003maf.2	+	49	5104	c.5024C>T	c.(5023-5025)ACG>ATG	p.T1675M	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.T1167M|DOCK2_uc003mah.2_Missense_Mutation_p.T231M	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1675					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCACCCAAGACGCCGAGAGTG	0.557													T	169506008	T	T	169506008	3	4	194	1	0	0	0	0	1	0	0	0	4687	536	19	1	5218	1	DOCK2	5	169506008	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	54328230	169506008	11409252	25	13757											
WDR27	253769	broad.mit.edu	37	chr6	170036474	170036474	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggggggtgcctacctcttaaTctcatctttgcaagtgtcaa	10	10	4	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr6:170036474T>C	uc003qwx.2	-	19	2516	c.1996A>G	c.(1996-1998)ATT>GTT	p.I666V	WDR27_uc003qwv.1_Intron|WDR27_uc010kkw.1_Missense_Mutation_p.I666V|WDR27_uc003qwy.2_Missense_Mutation_p.I539V			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	636										pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		TACCTCTTAATCTCATCTTTG	0.378													C	170036474	C	C	170036474	3	2	194	1	0	0	0	0	1	0	0	0	17281	1435	50	4	605	4	WDR27	6	170036474	Missense_Mutation	SNP	T	TCGA-27-2523-01A-01D-1494-08		170036474	1078593	26	13758											
FAM126A	84668	broad.mit.edu	37	chr7	23023600	23023600	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ggataactttatagagagatGaaactaaagaactcttgtct	8	5	2	4			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr7:23023600G>T	uc003svm.3	-	3	371	c.116C>A	c.(115-117)TCA>TAA	p.S39*	FAM126A_uc003svn.3_5'UTR|FAM126A_uc011jyr.1_Intron	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	39						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						ATAGAGAGATGAAACTAAAGA	0.259													T	23023600	T	T	23023600	4	4	194	1	0	0	0	0	0	1	0	0	5429	1294	45	5	1485	5	FAM126A	7	23023600	Nonsense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08		23023600	136115063	27	13759											
MUC17	140453	broad.mit.edu	37	chr7	100683180	100683180	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtggccagttctgaggctgGcaccctttcaacaactcctg	10	13	2	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr7:100683180G>A	uc003uxp.1	+	3	8536	c.8483G>A	c.(8482-8484)GGC>GAC	p.G2828D	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2828	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|45.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCTGAGGCTGGCACCCTTTCA	0.498													A	100683180	A	A	100683180	3	1	194	1	0	0	0	0	1	0	0	0	9974	1203	42	3	8493	3	MUC17	7	100683180	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	77659580	100683180	58455483	28	13760											
ARFGEF1	10565	broad.mit.edu	37	chr8	68140317	68140317	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaacattcttgggtgtgtcgTggaaagtaattcatccatag	10	6	2	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr8:68140317T>C	uc003xxo.1	-	25	3862	c.3472A>G	c.(3472-3474)ACG>GCG	p.T1158A	ARFGEF1_uc003xxl.1_Missense_Mutation_p.T612A|ARFGEF1_uc003xxn.1_Missense_Mutation_p.T141A	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1158					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GGGTGTGTCGTGGAAAGTAAT	0.318													C	68140317	C	C	68140317	3	2	194	1	0	0	0	0	1	0	0	0	852	1696	59	4	2137	4	ARFGEF1	8	68140317	Missense_Mutation	SNP	T	TCGA-27-2523-01A-01D-1494-08		68140317	78223705	29	13761											
SLC39A4	55630	broad.mit.edu	37	chr8	145642115	145642115	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcaggcggggacgccgtcGccgtcaccaccagcacagcc	13	18	1	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr8:145642115G>A	uc003zcq.2	-	1	159	c.59C>T	c.(58-60)GCG>GTG	p.A20V	SLC39A4_uc003zco.2_5'Flank|SLC39A4_uc003zcp.2_5'Flank	NM_130849	NP_570901	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter),	20						cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			GGACGCCGTCGCCGTCACCAC	0.662													A	145642115	A	A	145642115	3	1	194	1	0	0	0	0	1	0	0	0	14620	1087	38	1	2049	1	SLC39A4	8	145642115	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	77501798	145642115	721907	30	13762											
PAPPA	5069	broad.mit.edu	37	chr9	118997909	118997909	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacatctcaataggaaattcGtagacatgtaagtgcattct	7	7	2	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr9:118997909G>A	uc004bjn.2	+	7	3106	c.2725G>A	c.(2725-2727)GTA>ATA	p.V909I	PAPPA_uc011lxp.1_Missense_Mutation_p.V604I|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	909					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TAGGAAATTCGTAGACATGTA	0.517													A	118997909	A	A	118997909	3	1	194	1	0	0	0	0	1	0	0	0	11432	1145	40	1	2751	1	PAPPA	9	118997909	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08		118997909	22215522	31	13763											
LAMC3	10319	broad.mit.edu	37	chr9	133907535	133907535	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctccagtcctactattatgCcgtgtccgacttctctgtgg	9	13	1	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr9:133907535C>T	uc004caa.1	+	3	880	c.782C>T	c.(781-783)GCC>GTC	p.A261V		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	261	Laminin N-terminal.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TACTATTATGCCGTGTCCGAC	0.612													T	133907535	T	T	133907535	3	4	194	1	0	0	0	0	1	0	0	0	8616	739	26	3	792	3	LAMC3	9	133907535	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	14909626	133907535	7305896	32	13764											
LBX1	10660	broad.mit.edu	37	chr10	102987489	102987489	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggttggtgaaggccgtgcgCgactttcgccgcttcttagg	15	10	1	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr10:102987489C>T	uc001ksx.2	-	2	529	c.384G>A	c.(382-384)TCG>TCA	p.S128S	uc010qpy.1_5'Flank	NM_006562	NP_006553	P52954	LBX1_HUMAN	ladybird homeobox 1	128	Homeobox.				muscle organ development		sequence-specific DNA binding				0		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		AGGCCGTGCGCGACTTTCGCC	0.587													T	102987489	T	T	102987489	2	4	194	1	0	0	0	0	0	0	0	1	8653	755	27	1		1	LBX1	10	102987489	Silent	SNP	C	TCGA-27-2523-01A-01D-1494-08		102987489	32547258	33	13765											
OR52B2	255725	broad.mit.edu	37	chr11	6190634	6190634	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtcttgatgtcaaagaacCggtgggctacaccctcacgt	10	11	3	2	rs147668114	by1000genomes	TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr11:6190634C>T	uc010qzy.1	-	1	923	c.923G>A	c.(922-924)CGG>CAG	p.R308Q		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCAAAGAACCGGTGGGCTAC	0.478													T	6190634	T	T	6190634	3	4	194	1	0	0	0	0	1	0	0	0	11111	652	23	2	51	2	OR52B2	11	6190634	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08		6190634	128815882	34	13766											
INSC	387755	broad.mit.edu	37	chr11	15260573	15260573	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agctgcagtgaccctggctcGtctcagccgagacccagatg	12	14	1	3			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr11:15260573G>C	uc001mly.2	+	11	1533	c.1487G>C	c.(1486-1488)CGT>CCT	p.R496P	INSC_uc001mlz.2_Missense_Mutation_p.R449P|INSC_uc001mma.2_Missense_Mutation_p.R449P|INSC_uc010rcs.1_Missense_Mutation_p.R484P|INSC_uc001mmb.2_Missense_Mutation_p.R449P|INSC_uc001mmc.2_Missense_Mutation_p.R407P	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	496					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						ACCCTGGCTCGTCTCAGCCGA	0.607													C	15260573	C	C	15260573	3	2	194	1	0	0	0	0	1	0	0	0	7764	1145	40	5	1529	5	INSC	11	15260573	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	9069939	15260573	119745943	35	13767											
HIPK3	10114	broad.mit.edu	37	chr11	33362619	33362619	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttaagaccagttgcttcaagCagtactgctacactgactgc	8	11	1	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr11:33362619C>A	uc001mul.1	+	7	1989	c.1719C>A	c.(1717-1719)AGC>AGA	p.S573R	HIPK3_uc001mum.1_Missense_Mutation_p.S573R|HIPK3_uc009yjv.1_Missense_Mutation_p.S573R	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	573					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TTGCTTCAAGCAGTACTGCTA	0.318													A	33362619	A	A	33362619	3	1	194	1	0	0	0	0	1	0	0	0	7118	709	25	5	1741	5	HIPK3	11	33362619	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	18102046	33362619	101643897	36	13768											
DGKZ	8525	broad.mit.edu	37	chr11	46393049	46393049	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctcagtaccacagcaagGtgtcctgcttcatgctgcag	9	14	2	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr11:46393049G>A	uc001ncn.1	+	9	1344	c.1219G>A	c.(1219-1221)GTG>ATG	p.V407M	DGKZ_uc001nch.1_Missense_Mutation_p.V235M|DGKZ_uc010rgq.1_Missense_Mutation_p.V162M|DGKZ_uc001ncj.1_Missense_Mutation_p.V185M|DGKZ_uc010rgr.1_Missense_Mutation_p.V184M|DGKZ_uc001nck.1_Translation_Start_Site|DGKZ_uc001ncl.2_Missense_Mutation_p.V219M|DGKZ_uc001ncm.2_Missense_Mutation_p.V218M|DGKZ_uc009yky.1_Missense_Mutation_p.V219M|DGKZ_uc010rgs.1_Missense_Mutation_p.V196M	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	407	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CCACAGCAAGGTGTCCTGCTT	0.701													A	46393049	A	A	46393049	3	1	194	1	0	0	0	0	1	0	0	0	4474	1261	44	3	1696	3	DGKZ	11	46393049	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	13030430	46393049	88613467	37	13769											
PEX5	5830	broad.mit.edu	37	chr12	7343512	7343512	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcctttgggagtagcttctgAagatgaggtaaatagaccag	13	6	1	4			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr12:7343512A>G	uc009zfu.1	+	4	756	c.176A>G	c.(175-177)GAA>GGA	p.E59G	PEX5_uc001qsw.2_Missense_Mutation_p.E59G|PEX5_uc010sgc.1_Missense_Mutation_p.E74G|PEX5_uc001qsu.2_Missense_Mutation_p.E59G|PEX5_uc010sgd.1_Missense_Mutation_p.E80G|PEX5_uc001qsv.2_Missense_Mutation_p.E59G	NM_001131026	NP_001124498	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5 isoform d	59					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			ovary(1)	1						GTAGCTTCTGAAGATGAGGTA	0.428													G	7343512	G	G	7343512	3	3	194	1	0	0	0	0	1	0	0	0	11748	246	9	4	227	4	PEX5	12	7343512	Missense_Mutation	SNP	A	TCGA-27-2523-01A-01D-1494-08		7343512	126508383	38	13770											
CD163	9332	broad.mit.edu	37	chr12	7651670	7651670	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tacaaatgacagatgcatgaTctatgttgaagttatcatca	7	6	3	4			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr12:7651670T>A	uc001qsz.3	-	4	700	c.572A>T	c.(571-573)GAT>GTT	p.D191V	CD163_uc001qta.3_Missense_Mutation_p.D191V|CD163_uc009zfw.2_Missense_Mutation_p.D191V	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	191	SRCR 2.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						AGATGCATGATCTATGTTGAA	0.428													A	7651670	A	A	7651670	3	1	194	1	0	0	0	0	1	0	0	0	2967	1435	50	5	2950	5	CD163	12	7651670	Missense_Mutation	SNP	T	TCGA-27-2523-01A-01D-1494-08	308158	7651670	126200225	39	13771											
METTL7A	25840	broad.mit.edu	37	chr12	51319018	51319018	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtaacctgcaggagtttgCgggcccctccgggaaactct	12	13	1	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr12:51319018C>T	uc001rxb.2	+	1	485	c.197C>T	c.(196-198)GCG>GTG	p.A66V	METTL7A_uc010smv.1_Missense_Mutation_p.A66V	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	66						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						CAGGAGTTTGCGGGCCCCTCC	0.552													T	51319018	T	T	51319018	3	4	194	1	0	0	0	0	1	0	0	0	9505	768	27	1	199	1	METTL7A	12	51319018	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	43667348	51319018	82532877	40	13772											
TRHDE	29953	broad.mit.edu	37	chr12	73056901	73056901	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cacgagctgtggaaactgtcGaagccaatgtgcgctggaaa	13	9	0	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr12:73056901G>A	uc001sxa.2	+	19	3031	c.3001G>A	c.(3001-3003)GAA>AAA	p.E1001K		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1001	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GGAAACTGTCGAAGCCAATGT	0.373													A	73056901	A	A	73056901	3	1	194	1	0	0	0	0	1	0	0	0	16476	1059	37	2	3075	2	TRHDE	12	73056901	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	21737883	73056901	60794994	41	13773											
NAP1L1	4673	broad.mit.edu	37	chr12	76447581	76447581	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cataatttctggtccatcaaAagaaaagggatcagaatcat	7	7	4	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr12:76447581A>C	uc001sxw.2	-	9	1151	c.739T>G	c.(739-741)TTT>GTT	p.F247V	NAP1L1_uc001sxv.2_Missense_Mutation_p.F205V|NAP1L1_uc001sxz.2_Missense_Mutation_p.F178V|NAP1L1_uc001sxx.2_Missense_Mutation_p.F247V|NAP1L1_uc001sxy.2_Missense_Mutation_p.F184V|NAP1L1_uc010sty.1_Missense_Mutation_p.F204V|NAP1L1_uc010stz.1_Missense_Mutation_p.F64V|NAP1L1_uc010sua.1_Missense_Mutation_p.F247V|NAP1L1_uc001syb.2_Missense_Mutation_p.F247V|NAP1L1_uc001sya.2_Missense_Mutation_p.F205V|NAP1L1_uc001syc.2_Missense_Mutation_p.F258V	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	247					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				GGTCCATCAAAAGAAAAGGGA	0.333													C	76447581	C	C	76447581	3	2	194	1	0	0	0	0	1	0	0	0	10156	14	1	5	464	5	NAP1L1	12	76447581	Missense_Mutation	SNP	A	TCGA-27-2523-01A-01D-1494-08	3390680	76447581	57404314	42	13774											
CRY1	1407	broad.mit.edu	37	chr12	107393552	107393552	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccttccattttatcaaagCgtggattatttgttgctgct	7	8	1	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr12:107393552C>T	uc001tmi.3	-	7	1773	c.914G>A	c.(913-915)CGC>CAC	p.R305H		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	305	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						TTTATCAAAGCGTGGATTATT	0.433													T	107393552	T	T	107393552	3	4	194	1	0	0	0	0	1	0	0	0	3903	768	27	1	870	1	CRY1	12	107393552	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	30945971	107393552	26458343	43	13775											
PCDH9	5101	broad.mit.edu	37	chr13	67802035	67802035	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	actctgcccatttaacaattCataatgctgtacaccattga	4	11	2	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr13:67802035C>T	uc001vik.2	-	2	1230	c.538G>A	c.(538-540)GAA>AAA	p.E180K	PCDH9_uc001vil.2_Missense_Mutation_p.E180K|PCDH9_uc010thl.1_Missense_Mutation_p.E180K|PCDH9_uc001vin.3_Missense_Mutation_p.E180K	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	180	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TTTAACAATTCATAATGCTGT	0.423													T	67802035	T	T	67802035	3	4	194	1	0	0	0	0	1	0	0	0	11518	835	29	3	3191	3	PCDH9	13	67802035	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08		67802035	47367843	44	13776											
FOXA1	3169	broad.mit.edu	37	chr14	38060635	38060635	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgccggctccagggctgaggGctcgatggggctcctggtgg	19	12	0	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr14:38060635G>C	uc001wuf.2	-	2	1666	c.1354C>G	c.(1354-1356)CCC>GCC	p.P452A	FOXA1_uc010tpz.1_Missense_Mutation_p.P419A	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	452					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		AGGGCTGAGGGCTCGATGGGG	0.617													C	38060635	C	C	38060635	3	2	194	1	0	0	0	0	1	0	0	0	5989	1203	42	5	68	5	FOXA1	14	38060635	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08		38060635	69288905	45	13777											
LPCAT4	254531	broad.mit.edu	37	chr15	34653631	34653631	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagccaaaggcaccagccacCgtctgaggatcagagagctg	12	12	2	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr15:34653631C>T	uc001zig.2	-	11	1207	c.1113G>A	c.(1111-1113)ACG>ACA	p.T371T		NM_153613	NP_705841	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	371					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding				0						CACCAGCCACCGTCTGAGGAT	0.587													T	34653631	T	T	34653631	2	4	194	1	0	0	0	0	0	0	0	1	8913	639	23	2		2	LPCAT4	15	34653631	Silent	SNP	C	TCGA-27-2523-01A-01D-1494-08		34653631	67877761	46	13778											
ITGA11	22801	broad.mit.edu	37	chr15	68612685	68612685	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgaaggacagcgtgtatgcGgagcagtcctgcgcaggctt	15	10	0	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr15:68612685G>A	uc002ari.2	-	20	2541	c.2454C>T	c.(2452-2454)TCC>TCT	p.S818S	ITGA11_uc010bib.2_Silent_p.S818S	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	818	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	GCGTGTATGCGGAGCAGTCCT	0.592													A	68612685	A	A	68612685	2	1	194	1	0	0	0	0	0	0	0	1	7874	1103	39	2		2	ITGA11	15	68612685	Silent	SNP	G	TCGA-27-2523-01A-01D-1494-08	33959054	68612685	33918707	47	13779											
SETD1A	9739	broad.mit.edu	37	chr16	30976386	30976386	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccggagcctccagaacctggTggaggcgggggtggaggagg	21	9	0	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr16:30976386T>C	uc002ead.1	+	7	2009	c.1323T>C	c.(1321-1323)GGT>GGC	p.G441G		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	441	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CAGAACCTGGTGGAGGCGGGG	0.716													C	30976386	C	C	30976386	2	2	194	1	0	0	0	0	0	0	0	1	14130	1683	59	4		4	SETD1A	16	30976386	Silent	SNP	T	TCGA-27-2523-01A-01D-1494-08		30976386	59378367	48	13780											
PRSS36	146547	broad.mit.edu	37	chr16	31159857	31159857	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgcagcagggccaggtcggCgcccagctccacttggctgt	15	15	0	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr16:31159857C>T	uc002ebd.2	-	5	471	c.412G>A	c.(412-414)GCC>ACC	p.A138T	PRSS36_uc010vff.1_5'UTR|PRSS36_uc010vfg.1_Missense_Mutation_p.A138T|PRSS36_uc010vfh.1_Missense_Mutation_p.A138T	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	138	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						GCCAGGTCGGCGCCCAGCTCC	0.756													T	31159857	T	T	31159857	3	4	194	1	0	0	0	0	1	0	0	0	12625	768	27	1	2199	1	PRSS36	16	31159857	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	183471	31159857	59194896	49	13781											
POLR2A	5430	broad.mit.edu	37	chr17	7399844	7399844	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtctacgacctttgcaaggGcaaaaacatatgcgagggtg	12	8	1	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr17:7399844G>A	uc002ghf.3	+	4	683	c.449G>A	c.(448-450)GGC>GAC	p.G150D	POLR2A_uc002ghe.2_Missense_Mutation_p.G150D	NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	150					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				CTTTGCAAGGGCAAAAACATA	0.537													A	7399844	A	A	7399844	3	1	194	1	0	0	0	0	1	0	0	0	12214	1203	42	3	463	3	POLR2A	17	7399844	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08		7399844	73795366	50	13782											
KIAA0100	9703	broad.mit.edu	37	chr17	26967617	26967617	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acaataccacgcttgtgttcTccatcttaaccttgacctgg	6	13	2	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr17:26967617T>C	uc002hbu.2	-	8	950	c.851A>G	c.(850-852)GAG>GGG	p.E284G	KIAA0100_uc002hbv.2_Missense_Mutation_p.E284G|KIAA0100_uc010crr.1_Missense_Mutation_p.E141G	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	284						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GCTTGTGTTCTCCATCTTAAC	0.463													C	26967617	C	C	26967617	3	2	194	1	0	0	0	0	1	0	0	0	8154	1551	54	4	5984	4	KIAA0100	17	26967617	Missense_Mutation	SNP	T	TCGA-27-2523-01A-01D-1494-08	19567773	26967617	54227593	51	13783											
TUBG1	7283	broad.mit.edu	37	chr17	40766544	40766544	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttgcagaggatccgggaaCgcaagttggccaacttcatc	12	11	1	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr17:40766544C>T	uc002ian.2	+	10	1425	c.1027C>T	c.(1027-1029)CGC>TGC	p.R343C		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	343					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		GATCCGGGAACGCAAGTTGGC	0.657													T	40766544	T	T	40766544	3	4	194	1	0	0	0	0	1	0	0	0	16761	536	19	1	1065	1	TUBG1	17	40766544	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	13798927	40766544	40428666	52	13784											
TNFRSF11A	8792	broad.mit.edu	37	chr18	60021766	60021766	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcctgggcgcccagcacccGtgtacgggttggatgtgtgc	17	12	0	0	rs139968917		TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr18:60021766G>A	uc002lin.2	+	4	464	c.426G>A	c.(424-426)CCG>CCA	p.P142P	TNFRSF11A_uc010dpv.2_Silent_p.P142P	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	142	Extracellular (Potential).|TNFR-Cys 3.				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				CCCAGCACCCGTGTACGGGTT	0.647									Paget_Disease_of_Bone				A	60021766	A	A	60021766	2	1	194	1	0	0	0	0	0	0	0	1	16281	1159	40	1		1	TNFRSF11A	18	60021766	Silent	SNP	G	TCGA-27-2523-01A-01D-1494-08		60021766	18055482	53	13785											
MUC16	94025	broad.mit.edu	37	chr19	8962003	8962003	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cccaggagtcctgccaagccGatgaggatgacagcccagaa	12	13	0	3			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr19:8962003G>A	uc002mkp.2	-	83	43578	c.43374C>T	c.(43372-43374)ATC>ATT	p.I14458I	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.I1258I|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCCAAGCCGATGAGGATGA	0.502													A	8962003	A	A	8962003	2	1	194	1	0	0	0	0	0	0	0	1	9973	1048	37	2		2	MUC16	19	8962003	Silent	SNP	G	TCGA-27-2523-01A-01D-1494-08		8962003	50166980	54	13786											
LPPR2	64748	broad.mit.edu	37	chr19	11472001	11472001	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtgtgccgccccaactacaCggccctgggctgcctgccac	11	19	0	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr19:11472001C>T	uc002mre.1	+	6	837	c.500C>T	c.(499-501)ACG>ATG	p.T167M	LPPR2_uc002mrf.1_Missense_Mutation_p.T142M|LPPR2_uc010dxy.1_Translation_Start_Site	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	167						integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						CCCAACTACACGGCCCTGGGC	0.682													T	11472001	T	T	11472001	3	4	194	1	0	0	0	0	1	0	0	0	8925	536	19	1	514	1	LPPR2	19	11472001	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	2509998	11472001	47656982	55	13787											
CYP4F8	11283	broad.mit.edu	37	chr19	15726591	15726591	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggtgtttcccgcagccccGgaaacagaactggttcttgg	12	13	1	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr19:15726591G>A	uc002nbi.2	+	2	228	c.164G>A	c.(163-165)CGG>CAG	p.R55Q	CYP4F8_uc010xoi.1_Missense_Mutation_p.R55Q|CYP4F8_uc010xoj.1_Missense_Mutation_p.G17R	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	55					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CCGCAGCCCCGGAAACAGAAC	0.642													A	15726591	A	A	15726591	3	1	194	1	0	0	0	0	1	0	0	0	4191	1116	39	2	166	2	CYP4F8	19	15726591	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	4254590	15726591	43402392	56	13788											
PIK3R2	5296	broad.mit.edu	37	chr19	18277106	18277106	+	Frame_Shift_Del	DEL	T	-	-													tgagggcaacgagaaagagaTgcaaaggtgagtctggcgcc							TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr19:18277106delT	uc002nia.1	+	12	2065	c.1553delT	c.(1552-1554)ATGfs	p.M518fs	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	518					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						GAGAAAGAGATGCAAAGGTGA	0.428													-	18277106	-	-	18277106	7	5	194	1	0	1	0	1	0	0	0	0	11919	1464	51	0	1595	0	PIK3R2	19	18277106	Frame_Shift_Del	DEL	T	TCGA-27-2523-01A-01D-1494-08	2550515	18277106	40851877	57	13789											
KIRREL2	84063	broad.mit.edu	37	chr19	36351843	36351843	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaggcaaagccggagcccGtgtccgtggacgtgggggaa	18	10	0	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr19:36351843G>A	uc002ocb.3	+	8	1173	c.961G>A	c.(961-963)GTG>ATG	p.V321M	KIRREL2_uc002obz.3_Missense_Mutation_p.V321M|KIRREL2_uc002oca.3_Missense_Mutation_p.V271M|KIRREL2_uc002occ.3_Missense_Mutation_p.V268M|KIRREL2_uc002ocd.3_Missense_Mutation_p.V318M	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	321	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCCGGAGCCCGTGTCCGTGGA	0.672													A	36351843	A	A	36351843	3	1	194	1	0	0	0	0	1	0	0	0	8325	1145	40	1	991	1	KIRREL2	19	36351843	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	18074737	36351843	22777140	58	13790											
SLC17A7	57030	broad.mit.edu	37	chr19	49934369	49934369	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaggatgctggcgtagcgcGgggctatgtccaggtggttc	18	8	0	1	rs17855709		TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr19:49934369G>A	uc002pnp.2	-	11	1464	c.1292C>T	c.(1291-1293)CCG>CTG	p.P431L	SLC17A7_uc002pno.2_Missense_Mutation_p.P93L	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	431	Cytoplasmic (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GGCGTAGCGCGGGGCTATGTC	0.607													A	49934369	A	A	49934369	3	1	194	1	0	0	0	0	1	0	0	0	14422	1116	39	2	398	2	SLC17A7	19	49934369	Missense_Mutation	SNP	G	TCGA-27-2523-01A-01D-1494-08	13582526	49934369	9194614	59	13791											
SULF2	55959	broad.mit.edu	37	chr20	46386007	46386007	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgcggtccctctgaaacCtgcctttcaggcggtggtgc	12	14	2	1			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr20:46386007C>T	uc002xto.2	-	2	431	c.101G>A	c.(100-102)AGG>AAG	p.R34K	SULF2_uc002xtr.2_Missense_Mutation_p.R34K|SULF2_uc002xtq.2_Missense_Mutation_p.R34K|SULF2_uc010ghv.1_Missense_Mutation_p.R34K	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	34					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCTCTGAAACCTGCCTTTCAG	0.647													T	46386007	T	T	46386007	3	4	194	1	0	0	0	0	1	0	0	0	15370	681	24	3	2591	3	SULF2	20	46386007	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08		46386007	16639513	60	13792											
SLCO4A1	28231	broad.mit.edu	37	chr20	61291766	61291766	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccactgcctcttccacaggaCggagctgaccaccgagagcc	10	17	1	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr20:61291766C>T	uc002ydb.1	+	4	1095	c.890C>T	c.(889-891)ACG>ATG	p.T297M	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	297	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			TTCCACAGGACGGAGCTGACC	0.687													T	61291766	T	T	61291766	3	4	194	1	0	0	0	0	1	0	0	0	14729	536	19	1	900	1	SLCO4A1	20	61291766	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08	14905759	61291766	1733754	61	13793											
KRTAP10-5	386680	broad.mit.edu	37	chr21	46000294	46000294	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggggctgggctcacaggcCgcctggcagcaggggctgga	19	12	1	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr21:46000294C>T	uc002zfl.1	-	1	188	c.162G>A	c.(160-162)GCG>GCA	p.A54A	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198694	NP_941967	P60370	KR105_HUMAN	keratin associated protein 10-5	54	22 X 5 AA repeats of C-C-X(3).|2.					keratin filament					0						GCTCACAGGCCGCCTGGCAGC	0.493													T	46000294	T	T	46000294	2	4	194	1	0	0	0	0	0	0	0	1	8512	639	23	2		2	KRTAP10-5	21	46000294	Silent	SNP	C	TCGA-27-2523-01A-01D-1494-08		46000294	2129601	62	13794											
C1QTNF6	114904	broad.mit.edu	37	chr22	37581311	37581311	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcaggcagggcgtgggggCggccggaggaagaggctgag	22	8	1	2			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chr22:37581311C>T	uc003aqw.1	-	1	684	c.179G>A	c.(178-180)CGC>CAC	p.R60H	C1QTNF6_uc003aqx.1_Missense_Mutation_p.R79H|C1QTNF6_uc003aqy.1_Missense_Mutation_p.R79H|C1QTNF6_uc003aqz.1_RNA	NM_182486	NP_872292	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6	60						collagen					0						GGCGTGGGGGCGGCCGGAGGA	0.632													T	37581311	T	T	37581311	3	4	194	1	0	0	0	0	1	0	0	0	1967	768	27	1	608	1	C1QTNF6	22	37581311	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08		37581311	13723255	63	13795											
GABRQ	55879	broad.mit.edu	37	chrX	151820044	151820044	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcacatctgcgggataagctCcccaacatttcctgtatcaa	6	13	3	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chrX:151820044C>T	uc004ffp.1	+	8	977	c.957C>T	c.(955-957)CTC>CTT	p.L319L		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	319						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGGATAAGCTCCCCAACATTT	0.448													T	151820044	T	T	151820044	2	4	194	1	0	0	0	0	0	0	0	1	6175	842	30	3		3	GABRQ	23	151820044	Silent	SNP	C	TCGA-27-2523-01A-01D-1494-08		151820044	3450516	64	13796											
PCDH11Y	83259	broad.mit.edu	37	chrY	5605715	5605715	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgctgcaatcagccacagctCttctctgccacaggttattg	8	13	3	0			TCGA-27-2523-01A-01D-1494-08	TCGA-27-2523-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	d60f54f5-b154-42c4-99fb-cea4e7a33dc7	28ea912e-e998-458c-879e-38d55938a2fb	g.chrY:5605715C>T	uc004fqo.2	+	5	4489	c.3755C>T	c.(3754-3756)TCT>TTT	p.S1252F		NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	1252	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						AGCCACAGCTCTTCTCTGCCA	0.552													T	5605715	T	T	5605715	3	4	194	1	0	0	0	0	1	0	0	0	11509	913	32	3	3831	3	PCDH11Y	24	5605715	Missense_Mutation	SNP	C	TCGA-27-2523-01A-01D-1494-08		5605715	53767851	65	13797											
TAS1R1	80835	broad.mit.edu	37	chr1	6639227	6639227	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggctggtggtgtggaccccActgcctgctagggaatacca	14	11	0	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr1:6639227A>G	uc001ant.2	+	6	2109	c.2109A>G	c.(2107-2109)CCA>CCG	p.P703P	TAS1R1_uc001anu.2_Silent_p.P449P|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	703	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TGTGGACCCCACTGCCTGCTA	0.577													G	6639227	G	G	6639227	2	3	195	1	0	0	0	0	0	0	0	1	15559	146	6	4		4	TAS1R1	1	6639227	Silent	SNP	A	TCGA-27-2524-01A-01D-1494-08		6639227	242611394	1	13798											
PABPC4	8761	broad.mit.edu	37	chr1	40029374	40029374	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggagcagcagcagcaacaGcagcgcgtggcgctaagttc	16	11	0	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr1:40029374G>A	uc010oiv.1	-	12	2430	c.1532C>T	c.(1531-1533)GCT>GTT	p.A511V	PABPC4_uc001cdl.2_Missense_Mutation_p.A527V|PABPC4_uc001cdm.2_Missense_Mutation_p.A498V	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	511	Poly-Ala.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AGCAGCAACAGCAGCGCGTGG	0.572													A	40029374	A	A	40029374	3	1	195	1	0	0	0	0	1	0	0	0	11366	971	34	3	418	3	PABPC4	1	40029374	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	33390147	40029374	209221247	2	13799											
WDR47	22911	broad.mit.edu	37	chr1	109553699	109553699	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctcttatcatgactggttagTccacaggtgaggccatctaa	9	10	3	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr1:109553699T>A	uc001dwj.2	-	5	1345	c.969A>T	c.(967-969)GGA>GGT	p.G323G	WDR47_uc001dwl.2_Silent_p.G330G|WDR47_uc001dwi.2_Silent_p.G323G|WDR47_uc001dwk.2_Silent_p.G295G|WDR47_uc010ovf.1_Silent_p.G250G	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	323										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		GACTGGTTAGTCCACAGGTGA	0.448													A	109553699	A	A	109553699	2	1	195	1	0	0	0	0	0	0	0	1	17297	1654	58	5		5	WDR47	1	109553699	Silent	SNP	T	TCGA-27-2524-01A-01D-1494-08	69524325	109553699	139696922	3	13800											
RPTN	126638	broad.mit.edu	37	chr1	152127651	152127651	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctggtggccgttctgctGtgagtccctagactggaatc	12	11	1	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr1:152127651G>A	uc001ezs.1	-	3	1989	c.1924C>T	c.(1924-1926)CAG>TAG	p.Q642*		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	642	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						CCGTTCTGCTGTGAGTCCCTA	0.483													A	152127651	A	A	152127651	4	1	195	1	0	0	0	0	0	1	0	0	13664	1386	48	3	434	3	RPTN	1	152127651	Nonsense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	42573952	152127651	97122970	4	13801											
PLXNA2	5362	broad.mit.edu	37	chr1	208205103	208205103	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacaaacttctgcagggtgCcctggaggaggggtggggga	18	9	1	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr1:208205103C>T	uc001hgz.2	-	29	5815	c.5057G>A	c.(5056-5058)GGC>GAC	p.G1686D	PLXNA2_uc001hgy.2_5'Flank	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1686	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CTGCAGGGTGCCCTGGAGGAG	0.572													T	208205103	T	T	208205103	3	4	195	1	0	0	0	0	1	0	0	0	12120	753	26	3	643	3	PLXNA2	1	208205103	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	56077452	208205103	41045518	5	13802											
ADD2	119	broad.mit.edu	37	chr2	70890611	70890611	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ttcaggaaggagggggttcgGaatttctttttcttctttga	12	5	4	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr2:70890611G>C	uc002sgz.2	-	16	2592	c.2127C>G	c.(2125-2127)TTC>TTG	p.F709L	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_3'UTR|ADD2_uc002sha.2_Missense_Mutation_p.F403L|ADD2_uc002sgx.2_3'UTR	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	709	Interaction with calmodulin (Potential).				actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						AGGGGGTTCGGAATTTCTTTT	0.527													C	70890611	C	C	70890611	3	2	195	1	0	0	0	0	1	0	0	0	305	1165	41	5	57	5	ADD2	2	70890611	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08		70890611	172308762	6	13803											
CLASP1	23332	broad.mit.edu	37	chr2	122216417	122216417	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcctataacatacttaccCgaataattaacctaacagct	4	11	0	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr2:122216417C>T	uc002tnc.2	-	13	1703	c.1313G>A	c.(1312-1314)CGG>CAG	p.R438Q	CLASP1_uc002tna.2_5'Flank|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.R438Q|CLASP1_uc010yza.1_Missense_Mutation_p.R438Q|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tng.1_Missense_Mutation_p.R438Q	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	438	HEAT 3.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					CATACTTACCCGAATAATTAA	0.338													T	122216417	T	T	122216417	3	4	195	1	0	0	0	0	1	0	0	0	3454	666	23	2	3467	2	CLASP1	2	122216417	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	51325806	122216417	120982956	7	13804											
MBD5	55777	broad.mit.edu	37	chr2	149220206	149220206	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttaaaacatacctgcttactGatggaacatgcaagtgtggc	9	8	0	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr2:149220206G>A	uc002twm.3	+	7	1157	c.169G>A	c.(169-171)GAT>AAT	p.D57N	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.D57N	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	57	MBD.					chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CCTGCTTACTGATGGAACATG	0.353													A	149220206	A	A	149220206	3	1	195	1	0	0	0	0	1	0	0	0	9347	1290	45	3	175	3	MBD5	2	149220206	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	27003789	149220206	93979167	8	13805											
PMS1	5378	broad.mit.edu	37	chr2	190660525	190660525	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatttgataaaattgaggtgCgagataacggggagggtatc	15	3	0	3			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr2:190660525C>T	uc002urh.3	+	3	692	c.163C>T	c.(163-165)CGA>TGA	p.R55*	PMS1_uc010zga.1_Nonsense_Mutation_p.R55*|PMS1_uc010zgb.1_Intron|PMS1_uc002urk.3_Nonsense_Mutation_p.R55*|PMS1_uc002uri.3_Nonsense_Mutation_p.R55*|PMS1_uc010zgc.1_5'UTR|PMS1_uc010zgd.1_Intron|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Nonsense_Mutation_p.R55*|PMS1_uc010frz.2_Nonsense_Mutation_p.R55*|PMS1_uc010zfz.1_Nonsense_Mutation_p.R55*	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	55					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			AATTGAGGTGCGAGATAACGG	0.323			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					T	190660525	T	T	190660525	4	4	195	1	0	0	0	0	0	1	0	0	12142	760	27	1	169	1	PMS1	2	190660525	Nonsense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	41440319	190660525	52538848	9	13806											
DYTN	391475	broad.mit.edu	37	chr2	207530695	207530695	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgacaaattctttcttcctGggaggtgtatatagcttgca	9	8	2	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr2:207530695G>A	uc002vbr.1	-	10	1156	c.1039C>T	c.(1039-1041)CAG>TAG	p.Q347*		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	347	Potential.					plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		CTTTCTTCCTGGGAGGTGTAT	0.408													A	207530695	A	A	207530695	4	1	195	1	0	0	0	0	0	1	0	0	4861	1357	47	3	709	3	DYTN	2	207530695	Nonsense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	16870170	207530695	35668678	10	13807											
WNT10A	80326	broad.mit.edu	37	chr2	219745829	219745829	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgctggctgctgccatgcccAggtgagccctcacctcatgc	11	16	2	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr2:219745829A>T	uc002vjd.1	+	1	575	c.112A>T	c.(112-114)AGG>TGG	p.R38W		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	38					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCCATGCCCAGGTGAGCCCT	0.687													T	219745829	T	T	219745829	3	4	195	1	0	0	0	0	1	0	0	0	17379	202	7	5	114	5	WNT10A	2	219745829	Missense_Mutation	SNP	A	TCGA-27-2524-01A-01D-1494-08	12215134	219745829	23453544	11	13808											
KCNJ13	3769	broad.mit.edu	37	chr2	233632952	233632952	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaattgtcaatgctttgtccAttgatgtggatatccaggtc	9	7	1	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr2:233632952A>G	uc002vto.2	-	2	1075	c.1032T>C	c.(1030-1032)AAT>AAC	p.N344N	GIGYF2_uc010zmj.1_Intron|GIGYF2_uc002vtg.2_Intron|GIGYF2_uc002vtj.3_Intron|GIGYF2_uc002vti.3_Intron|GIGYF2_uc002vtk.3_Intron|GIGYF2_uc002vth.3_Intron|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc010zml.1_Intron|KCNJ13_uc002vtn.2_3'UTR|KCNJ13_uc002vtp.2_Silent_p.N344N	NM_002242	NP_002233	O60928	IRK13_HUMAN	potassium inwardly-rectifying channel J13	344	Cytoplasmic (By similarity).					voltage-gated potassium channel complex	inward rectifier potassium channel activity				0		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0306)|Lung NSC(271;0.0908)		Epithelial(121;5.9e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0617)		TGCTTTGTCCATTGATGTGGA	0.383													G	233632952	G	G	233632952	2	3	195	1	0	0	0	0	0	0	0	1	8047	214	8	4		4	KCNJ13	2	233632952	Silent	SNP	A	TCGA-27-2524-01A-01D-1494-08	13887123	233632952	9566421	12	13809											
CAND2	23066	broad.mit.edu	37	chr3	12856711	12856711	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggcagctgccaagtgcatcGcagccttgatcagctcgcgg	14	13	1	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr3:12856711G>T	uc003bxk.2	+	8	1127	c.1078G>T	c.(1078-1080)GCA>TCA	p.A360S	CAND2_uc003bxj.2_Missense_Mutation_p.A267S	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	360	HEAT 8.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						CAAGTGCATCGCAGCCTTGAT	0.597													T	12856711	T	T	12856711	3	4	195	1	0	0	0	0	1	0	0	0	2616	1087	38	5	1108	5	CAND2	3	12856711	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08		12856711	185165719	13	13810											
SLC7A11	23657	broad.mit.edu	37	chr4	139100426	139100426	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	catataataaagagataataCgcagggactccagtcagagt	9	7	1	2	rs145453312	by1000genomes	TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr4:139100426C>A	uc011chb.1	-	11	1669	c.1389G>T	c.(1387-1389)GCG>GCT	p.A463A		NM_014331	NP_055146	Q9UPY5	XCT_HUMAN	solute carrier family 7, (cationic amino acid	463	Helical; (Potential).				blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			skin(1)	1	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	AGAGATAATACGCAGGGACTC	0.423													A	139100426	A	A	139100426	2	1	195	1	0	0	0	0	0	0	0	1	14694	523	19	5		5	SLC7A11	4	139100426	Silent	SNP	C	TCGA-27-2524-01A-01D-1494-08		139100426	52053850	14	13811											
CARD6	84674	broad.mit.edu	37	chr5	40843343	40843343	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tttctcctggaataaaacagCctgaagcccctgagatcaca	7	12	2	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr5:40843343C>A	uc003jmg.2	+	2	448	c.373C>A	c.(373-375)CCT>ACT	p.P125T		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	125					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						AATAAAACAGCCTGAAGCCCC	0.403													A	40843343	A	A	40843343	3	1	195	1	0	0	0	0	1	0	0	0	2650	739	26	5	379	5	CARD6	5	40843343	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08		40843343	140071917	15	13812											
HARS	3035	broad.mit.edu	37	chr5	140056309	140056309	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccccacacatggcaccttgCgccctttggggtcgaacatg	11	15	0	0	rs151258227		TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr5:140056309C>T	uc003lgv.2	-	10	1206	c.1124G>A	c.(1123-1125)CGC>CAC	p.R375H	HARS_uc003lgu.2_Missense_Mutation_p.R306H|HARS_uc011czm.1_Missense_Mutation_p.R335H|HARS_uc003lgw.2_Missense_Mutation_p.R355H|HARS_uc011czn.1_Missense_Mutation_p.R315H|HARS_uc010jfu.2_Missense_Mutation_p.R375H|HARS_uc011czo.1_Missense_Mutation_p.R301H|HARS_uc011czp.1_Missense_Mutation_p.R261H|HARS_uc011czq.1_Missense_Mutation_p.R265H	NM_002109	NP_002100	P12081	SYHC_HUMAN	histidyl-tRNA synthetase	375					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	TGGCACCTTGCGCCCTTTGGG	0.597													T	140056309	T	T	140056309	3	4	195	1	0	0	0	0	1	0	0	0	6959	768	27	1	421	1	HARS	5	140056309	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	99212966	140056309	40858951	16	13813											
PCDHB13	56123	broad.mit.edu	37	chr5	140594357	140594357	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcactggatggtggctctcCgcccagatctggcactgctc	12	14	2	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr5:140594357C>T	uc003lja.1	+	1	849	c.662C>T	c.(661-663)CCG>CTG	p.P221L		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	221	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.P221L(1)		skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGCTCTCCGCCCAGATCT	0.532													T	140594357	T	T	140594357	3	4	195	1	0	0	0	0	1	0	0	0	11538	652	23	2	664	2	PCDHB13	5	140594357	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	538048	140594357	40320903	17	13814											
RREB1	6239	broad.mit.edu	37	chr6	7229251	7229251	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggtgcgaaacaaacctgCggaggtgcatcagcgagcaa	13	11	1	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr6:7229251C>T	uc003mxc.2	+	10	1309	c.919C>T	c.(919-921)CGG>TGG	p.R307W	RREB1_uc003mxb.2_Missense_Mutation_p.R307W|RREB1_uc010jnx.2_Missense_Mutation_p.R307W	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	307					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				AACAAACCTGCGGAGGTGCAT	0.507													T	7229251	T	T	7229251	3	4	195	1	0	0	0	0	1	0	0	0	13679	759	27	1	945	1	RREB1	6	7229251	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08		7229251	163885816	18	13815											
TDP2	51567	broad.mit.edu	37	chr6	24658115	24658115	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aataacttcctgtagaaataTcacatctgggctgtacctaa	6	9	2	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr6:24658115T>C	uc003nej.2	-	4	467	c.442A>G	c.(442-444)ATA>GTA	p.I148V	TDP2_uc003nei.2_Missense_Mutation_p.I36V|TDP2_uc010jpu.1_Missense_Mutation_p.I148V	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	148					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2						TGTAGAAATATCACATCTGGG	0.313								Direct_reversal_of_damage|Editing_and_processing_nucleases					C	24658115	C	C	24658115	3	2	195	1	0	0	0	0	1	0	0	0	15726	1435	50	4	662	4	TDP2	6	24658115	Missense_Mutation	SNP	T	TCGA-27-2524-01A-01D-1494-08	17428864	24658115	146456952	19	13816											
MDC1	9656	broad.mit.edu	37	chr6	30671570	30671570	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggagctccggggtgaacctaGatctacctgctggttccacc	12	13	1	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr6:30671570G>A	uc003nrg.3	-	10	5830	c.5390C>T	c.(5389-5391)TCT>TTT	p.S1797F	MDC1_uc003nrf.3_Missense_Mutation_p.S428F|MDC1_uc011dmp.1_Missense_Mutation_p.S1404F	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1797	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GGTGAACCTAGATCTACCTGC	0.537								Other_conserved_DNA_damage_response_genes					A	30671570	A	A	30671570	3	1	195	1	0	0	0	0	1	0	0	0	9403	942	33	3	903	3	MDC1	6	30671570	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	6013455	30671570	140443497	20	13817											
DST	667	broad.mit.edu	37	chr6	56566691	56566691	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaaaacatcatacctggcGtcttttcaaatagtcaagtg	6	9	5	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr6:56566691G>A	uc003pdf.2	-	7	878	c.850C>T	c.(850-852)CGC>TGC	p.R284C	DST_uc003pcz.3_Missense_Mutation_p.R106C|DST_uc011dxj.1_Missense_Mutation_p.R135C|DST_uc011dxk.1_Missense_Mutation_p.R146C|DST_uc011dxl.1_Missense_Mutation_p.R135C	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	106	CH 1.|Actin-binding.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CATACCTGGCGTCTTTTCAAA	0.343													A	56566691	A	A	56566691	3	1	195	1	0	0	0	0	1	0	0	0	4783	1160	40	1		1	DST	6	56566691	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	25895121	56566691	114548376	21	13818											
PMS2	5395	broad.mit.edu	37	chr7	6026906	6026906	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaatccacggaagtgctgCcgtgccccgagtccttctcc	10	16	1	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr7:6026906C>T	uc003spl.2	-	11	1577	c.1490G>A	c.(1489-1491)GGC>GAC	p.G497D	PMS2_uc003spj.2_Missense_Mutation_p.G391D|PMS2_uc003spk.2_Missense_Mutation_p.G362D|PMS2_uc011jwl.1_Missense_Mutation_p.G362D|PMS2_uc010ktg.2_Missense_Mutation_p.G186D|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Missense_Mutation_p.G497D	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	497					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		GGAAGTGCTGCCGTGCCCCGA	0.632			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				T	6026906	T	T	6026906	3	4	195	1	0	0	0	0	1	0	0	0	12143	739	26	3	1118	3	PMS2	7	6026906	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08		6026906	153111757	22	13819											
TARP	445347	broad.mit.edu	37	chr7	38305013	38305013	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttattattctcatgtctgaCgatacatctgtgttctttgt	6	7	4	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr7:38305013C>T	uc003tge.1	-	5	1071	c.694G>A	c.(694-696)GTC>ATC	p.V232I	uc003tfz.1_Intron|TARP_uc003tgb.2_Missense_Mutation_p.V28I|TARP_uc003tgc.1_Missense_Mutation_p.V28I|TARP_uc003tgd.1_Missense_Mutation_p.V28I|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						TCATGTCTGACGATACATCTG	0.393													T	38305013	T	T	38305013	3	4	195	1	0	0	0	0	1	0	0	0	15555	536	19	1	265	1	TARP	7	38305013	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	32278107	38305013	120833650	23	13820											
PCLO	27445	broad.mit.edu	37	chr7	82584287	82584287	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcataaatctgttctgaaagTcttatcttttgctctcttcc	4	10	6	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr7:82584287T>C	uc003uhx.2	-	5	6271	c.5982A>G	c.(5980-5982)AGA>AGG	p.R1994R	PCLO_uc003uhv.2_Silent_p.R1994R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1925					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTTCTGAAAGTCTTATCTTTT	0.388													C	82584287	C	C	82584287	2	2	195	1	0	0	0	0	0	0	0	1	11583	1664	58	4		4	PCLO	7	82584287	Silent	SNP	T	TCGA-27-2524-01A-01D-1494-08	44279274	82584287	76554376	24	13821											
TRRAP	8295	broad.mit.edu	37	chr7	98509724	98509724	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggaatatctccttgatcGcctgccagaaatgggctcca	11	11	1	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr7:98509724G>A	uc003upp.2	+	18	2296	c.2087G>A	c.(2086-2088)CGC>CAC	p.R696H	TRRAP_uc011kis.1_Missense_Mutation_p.R696H|TRRAP_uc003upr.2_Missense_Mutation_p.R388H	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	696					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTCCTTGATCGCCTGCCAGAA	0.468													A	98509724	A	A	98509724	3	1	195	1	0	0	0	0	1	0	0	0	16598	1087	38	1	2153	1	TRRAP	7	98509724	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	15925437	98509724	60628939	25	13822											
PLOD3	8985	broad.mit.edu	37	chr7	100852149	100852149	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttacctcatgccggccgccTgaccactggccgtagtgctc	10	17	1	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr7:100852149T>C	uc003uyd.2	-	16	2229	c.1773A>G	c.(1771-1773)TCA>TCG	p.S591S	PLOD3_uc010lhs.2_Silent_p.S156S	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	591					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	GCCGGCCGCCTGACCACTGGC	0.582													C	100852149	C	C	100852149	2	2	195	1	0	0	0	0	0	0	0	1	12103	1567	55	4		4	PLOD3	7	100852149	Silent	SNP	T	TCGA-27-2524-01A-01D-1494-08	2342425	100852149	58286514	26	13823											
KIAA1549	57670	broad.mit.edu	37	chr7	138603251	138603251	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttagatgaaacatcagttGgtgaagcagaggacgcaaat	13	5	1	4			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr7:138603251G>A	uc011kql.1	-	2	1170	c.1121C>T	c.(1120-1122)CCA>CTA	p.P374L	KIAA1549_uc003vuk.3_Missense_Mutation_p.P324L|KIAA1549_uc011kqj.1_Missense_Mutation_p.P374L	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	374						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						AACATCAGTTGGTGAAGCAGA	0.507			O	BRAF	pilocytic astrocytoma								A	138603251	A	A	138603251	3	1	195	1	0	0	0	0	1	0	0	0	8244	1348	47	3	4807	3	KIAA1549	7	138603251	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	37751102	138603251	20535412	27	13824											
TRPV5	56302	broad.mit.edu	37	chr7	142609825	142609825	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcatcaataacagtgagAaaaagctcaaaggtggtgaa	12	5	2	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr7:142609825A>G	uc003wby.1	-	13	1875	c.1611T>C	c.(1609-1611)TTT>TTC	p.F537F		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	537					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					TAACAGTGAGAAAAAGCTCAA	0.502													G	142609825	G	G	142609825	2	3	195	1	0	0	0	0	0	0	0	1	16596	243	9	4		4	TRPV5	7	142609825	Silent	SNP	A	TCGA-27-2524-01A-01D-1494-08	4006574	142609825	16528838	28	13825											
ACCN3	9311	broad.mit.edu	37	chr7	150749681	150749681	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctcccacccctccctgtgCcgtcaccaagactctctccg	5	22	2	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr7:150749681C>T	uc003win.2	+	11	1906	c.1538C>T	c.(1537-1539)GCC>GTC	p.A513V	ACCN3_uc003wio.2_Missense_Mutation_p.P520S|ACCN3_uc003wip.2_Silent_p.C493C|ACCN3_uc003wiq.2_RNA	NM_004769	NP_004760	Q9UHC3	ACCN3_HUMAN	amiloride-sensitive cation channel 3 isoform a	513	Cytoplasmic (Potential).				sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCCCTGTGCCGTCACCAAG	0.632													T	150749681	T	T	150749681	3	4	195	1	0	0	0	0	1	0	0	0	130	748	26	3	1600	3	ACCN3	7	150749681	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	8139856	150749681	8388982	29	13826											
ECM2	1842	broad.mit.edu	37	chr9	95263237	95263237	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catagccagggatccgttcaAtctggttcccaaggagtact	10	11	2	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr9:95263237A>G	uc004ash.2	-	9	1768	c.1703T>C	c.(1702-1704)ATT>ACT	p.I568T	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.I546T|ECM2_uc011lty.1_Missense_Mutation_p.I568T|ECM2_uc004asg.2_Missense_Mutation_p.I546T|ECM2_uc010mqz.1_5'UTR	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	568	LRR 9.				cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						GATCCGTTCAATCTGGTTCCC	0.478													G	95263237	G	G	95263237	3	3	195	1	0	0	0	0	1	0	0	0	4898	101	4	4	404	4	ECM2	9	95263237	Missense_Mutation	SNP	A	TCGA-27-2524-01A-01D-1494-08		95263237	45950194	30	13827											
KIAA1217	56243	broad.mit.edu	37	chr10	24832950	24832950	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccctaagaagcaactcgccgCtctcactcaagccattcgca	6	17	2	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr10:24832950C>A	uc001iru.3	+	19	5154	c.4751C>A	c.(4750-4752)GCT>GAT	p.A1584D	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Missense_Mutation_p.A1267D|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Missense_Mutation_p.A420D	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1584					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CAACTCGCCGCTCTCACTCAA	0.473													A	24832950	A	A	24832950	3	1	195	1	0	0	0	0	1	0	0	0	8216	797	28	5	4825	5	KIAA1217	10	24832950	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08		24832950	110701797	31	13828											
AGAP7	653268	broad.mit.edu	37	chr10	51464835	51464835	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttggaacggatccaccgttCcttctcttccctcgtggact	8	14	1	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr10:51464835C>T	uc001jio.2	-	7	1747	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron	NM_001077685	NP_001071153	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	541	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						ATCCACCGTTCCTTCTCTTCC	0.572													T	51464835	T	T	51464835	3	4	195	1	0	0	0	0	1	0	0	0	373	864	30	3	374	3	AGAP7	10	51464835	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	26631885	51464835	84069912	32	13829											
PTEN	5728	broad.mit.edu	37	chr10	89692904	89692904	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgtaaagctggaaagggaCgaactggtgtaatgatatgt	13	4	0	1	rs121909224		TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr10:89692904C>T	uc001kfb.2	+	6	1419	c.388C>T	c.(388-390)CGA>TGA	p.R130*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).	R->M: Does not affect the ability to inhibit AKT/PKB activation.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130G(65)|p.R130*(61)|p.R130Q(43)|p.R130fs*4(12)|p.R130L(7)|p.R130P(4)|p.R55fs*1(4)|p.K128_R130del(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.K128fs*47(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.R130R(1)|p.F56fs*2(1)|p.G129fs*50(1)|p.G129fs*51(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGGAAAGGGACGAACTGGTGT	0.403	R130G(OV56_OVARY)|R130G(KMBC2_URINARY_TRACT)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89692904	T	T	89692904	4	4	195	1	0	0	0	0	0	1	0	0	12738	528	19	1	406	1	PTEN	10	89692904	Nonsense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	38228069	89692904	45841843	33	13830											
OR51B2	79345	broad.mit.edu	37	chr11	5344773	5344773	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaatgtcaaacccatcactGtaacatagaagataagaaca	6	8	2	4			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr11:5344773G>A	uc001mao.1	-	1	810	c.755C>T	c.(754-756)ACA>ATA	p.T252I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCCATCACTGTAACATAGAA	0.393													A	5344773	A	A	5344773	3	1	195	1	0	0	0	0	1	0	0	0	11089	1377	48	3	187	3	OR51B2	11	5344773	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08		5344773	129661743	34	13831											
OR52D1	390066	broad.mit.edu	37	chr11	5510785	5510785	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cacatctttctggctaatctCtatgtgctggtgcctcctgt	8	12	3	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr11:5510785C>G	uc010qzg.1	+	1	849	c.849C>G	c.(847-849)CTC>CTG	p.L283L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGCTAATCTCTATGTGCTGG	0.493													G	5510785	G	G	5510785	2	3	195	1	0	0	0	0	0	0	0	1	11114	900	32	5		5	OR52D1	11	5510785	Silent	SNP	C	TCGA-27-2524-01A-01D-1494-08	166012	5510785	129495731	35	13832											
SLC17A6	57084	broad.mit.edu	37	chr11	22363249	22363249	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctgcatctccttcggtatcCgctgcaacctgggcgtggcc	11	15	2	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr11:22363249C>A	uc001mqk.2	+	2	675	c.262C>A	c.(262-264)CGC>AGC	p.R88S		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	88	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						CTTCGGTATCCGCTGCAACCT	0.642													A	22363249	A	A	22363249	3	1	195	1	0	0	0	0	1	0	0	0	14421	652	23	5	268	5	SLC17A6	11	22363249	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	16852464	22363249	112643267	36	13833											
CD5	921	broad.mit.edu	37	chr11	60885944	60885944	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtgtcactctctgggcctgaCctgcttaggtgggtaactag	13	10	2	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr11:60885944C>A	uc009ynk.2	+	3	495	c.392C>A	c.(391-393)ACC>AAC	p.T131N		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	131	Extracellular (Potential).|SRCR 1.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		CTGGGCCTGACCTGCTTAGGT	0.607													A	60885944	A	A	60885944	3	1	195	1	0	0	0	0	1	0	0	0	3021	507	18	5	402	5	CD5	11	60885944	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	38522695	60885944	74120572	37	13834											
OR2AT4	341152	broad.mit.edu	37	chr11	74799893	74799893	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgtaaatgagggggttgagaAttggtgtgagaatggcatat	16	1	0	3			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr11:74799893A>T	uc010rro.1	-	1	866	c.866T>A	c.(865-867)ATT>AAT	p.I289N		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGGGTTGAGAATTGGTGTGAG	0.488													T	74799893	T	T	74799893	3	4	195	1	0	0	0	0	1	0	0	0	10987	101	4	5	99	5	OR2AT4	11	74799893	Missense_Mutation	SNP	A	TCGA-27-2524-01A-01D-1494-08	13913949	74799893	60206623	38	13835											
MLL	4297	broad.mit.edu	37	chr11	118382698	118382698	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cattgacagataaagtccagGaagctcgatcaaatgcccgc	9	11	1	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr11:118382698G>C	uc001pta.2	+	31	11118	c.11095G>C	c.(11095-11097)GAA>CAA	p.E3699Q	MLL_uc001ptb.2_Missense_Mutation_p.E3702Q	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3699	FYR C-terminal.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TAAAGTCCAGGAAGCTCGATC	0.418			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								C	118382698	C	C	118382698	3	2	195	1	0	0	0	0	1	0	0	0	9620	1175	41	5	11217	5	MLL	11	118382698	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	43582805	118382698	16623818	39	13836											
OR8G2	26492	broad.mit.edu	37	chr11	124095935	124095935	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccggctttatgttgagactcTttttgtgcaagactaatgtg	10	7	1	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr11:124095935T>C	uc010saf.1	+	1	538	c.538T>C	c.(538-540)TTT>CTT	p.F180L		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	180						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GTTGAGACTCTTTTTGTGCAA	0.428													C	124095935	C	C	124095935	3	2	195	1	0	0	0	0	1	0	0	0	11235	1609	56	4	540	4	OR8G2	11	124095935	Missense_Mutation	SNP	T	TCGA-27-2524-01A-01D-1494-08	5713237	124095935	10910581	40	13837											
ERP27	121506	broad.mit.edu	37	chr12	15073953	15073953	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaatgctttcaatgtcttcGtcctctaaattcagttgttc	5	10	5	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr12:15073953G>A	uc001rco.2	-	4	384	c.363C>T	c.(361-363)GAC>GAT	p.D121D		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	121	Thioredoxin.					endoplasmic reticulum lumen				breast(1)	1						CAATGTCTTCGTCCTCTAAAT	0.333													A	15073953	A	A	15073953	2	1	195	1	0	0	0	0	0	0	0	1	5241	1136	40	1		1	ERP27	12	15073953	Silent	SNP	G	TCGA-27-2524-01A-01D-1494-08		15073953	118777942	41	13838											
LST-3TM12	338821	broad.mit.edu	37	chr12	21175884	21175884	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atagtaccattggggatttcTtacattgatgattttgcaaa	8	5	1	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr12:21175884T>C	uc010sin.1	+	4	441	c.441T>C	c.(439-441)TCT>TCC	p.S147S	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Silent_p.S194S	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	147						membrane	transporter activity				0						TGGGGATTTCTTACATTGATG	0.383													C	21175884	C	C	21175884	2	2	195	1	0	0	0	0	0	0	0	1	9066	1596	56	4		4	LST-3TM12	12	21175884	Silent	SNP	T	TCGA-27-2524-01A-01D-1494-08	6101931	21175884	112676011	42	13839											
ABCD2	225	broad.mit.edu	37	chr12	40012546	40012546	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcgagtgcacataccgcaaaTagccttttctatgtgcttcc	7	12	1	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr12:40012546T>C	uc001rmb.2	-	1	1298	c.872A>G	c.(871-873)TAT>TGT	p.Y291C		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	291	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						ATACCGCAAATAGCCTTTTCT	0.413													C	40012546	C	C	40012546	3	2	195	1	0	0	0	0	1	0	0	0	61	1406	49	4	1390	4	ABCD2	12	40012546	Missense_Mutation	SNP	T	TCGA-27-2524-01A-01D-1494-08	18836662	40012546	93839349	43	13840											
AMHR2	269	broad.mit.edu	37	chr12	53823327	53823327	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtgccattggagacctggGccttgccttggtgctccctg	14	12	0	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr12:53823327G>A	uc001scx.1	+	8	1136	c.1058G>A	c.(1057-1059)GGC>GAC	p.G353D	AMHR2_uc009zmy.1_Missense_Mutation_p.G353D	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	353	Cytoplasmic (Potential).|Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)	GGAGACCTGGGCCTTGCCTTG	0.572									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				A	53823327	A	A	53823327	3	1	195	1	0	0	0	0	1	0	0	0	573	1203	42	3	1088	3	AMHR2	12	53823327	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	13810781	53823327	80028568	44	13841											
LUM	4060	broad.mit.edu	37	chr12	91497971	91497971	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgacttcgttagcaacacGtagacattcatacatatccg	7	10	1	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr12:91497971G>A	uc001tbm.2	-	3	1377	c.988C>T	c.(988-990)CGT>TGT	p.R330C	LUM_uc001tbn.2_RNA	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	330					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						TTAGCAACACGTAGACATTCA	0.383													A	91497971	A	A	91497971	3	1	195	1	0	0	0	0	1	0	0	0	9085	1145	40	1	32	1	LUM	12	91497971	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	37674644	91497971	42353924	45	13842											
CORO1C	23603	broad.mit.edu	37	chr12	109052586	109052586	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaagctgtgcagatcagactGccattccggttccagctcac	10	13	2	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr12:109052586G>C	uc001tnj.2	-	5	654	c.558C>G	c.(556-558)GGC>GGG	p.G186G	CORO1C_uc009zva.2_Silent_p.G239G|CORO1C_uc010sxf.1_Silent_p.G149G	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	186	WD 3.				actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						AGATCAGACTGCCATTCCGGT	0.433													C	109052586	C	C	109052586	2	2	195	1	0	0	0	0	0	0	0	1	3755	1306	46	5		5	CORO1C	12	109052586	Silent	SNP	G	TCGA-27-2524-01A-01D-1494-08	17554615	109052586	24799309	46	13843											
TRPV4	59341	broad.mit.edu	37	chr12	110226433	110226433	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaaggtctcgctgtcacgGcacgaggggtaagtgggcac	16	10	2	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr12:110226433G>A	uc001tpj.1	-	12	2075	c.1980C>T	c.(1978-1980)TGC>TGT	p.C660C	TRPV4_uc001tpg.1_Silent_p.C626C|TRPV4_uc001tph.1_Silent_p.C613C|TRPV4_uc001tpi.1_Silent_p.C553C|TRPV4_uc001tpk.1_Silent_p.C660C|TRPV4_uc001tpl.1_Silent_p.C600C	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	660					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CGCTGTCACGGCACGAGGGGT	0.597													A	110226433	A	A	110226433	2	1	195	1	0	0	0	0	0	0	0	1	16595	1195	42	3		3	TRPV4	12	110226433	Silent	SNP	G	TCGA-27-2524-01A-01D-1494-08	1173847	110226433	23625462	47	13844											
TRPV4	59341	broad.mit.edu	37	chr12	110238470	110238470	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggctggaagaagcgcccaCgggcctgggcgtggacatca	17	11	1	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr12:110238470C>T	uc001tpj.1	-	4	901	c.806G>A	c.(805-807)CGT>CAT	p.R269H	TRPV4_uc001tpg.1_Missense_Mutation_p.R235H|TRPV4_uc001tph.1_Intron|TRPV4_uc001tpi.1_Intron|TRPV4_uc001tpk.1_Missense_Mutation_p.R269H|TRPV4_uc001tpl.1_Missense_Mutation_p.R269H	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	269	Cytoplasmic (Potential).		R -> H (in CMT2C and DSMAC).|R -> C (in CMT2C).		actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GAAGCGCCCACGGGCCTGGGC	0.632													T	110238470	T	T	110238470	3	4	195	1	0	0	0	0	1	0	0	0	16595	536	19	1	1857	1	TRPV4	12	110238470	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	12037	110238470	23613425	48	13845											
RB1	5925	broad.mit.edu	37	chr13	48951053	48951053	+	Splice_Site	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttctgtttttacctcctaaaGaactgcacagtgaatccaaa	5	10	1	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr13:48951053G>C	uc001vcb.2	+	13	1382	c.1216_splice	c.e13-1	p.N406_splice	RB1_uc010act.1_Splice_Site_p.N107_splice	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(10)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACCTCCTAAAGAACTGCACAG	0.318		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			C	48951053	C	C	48951053	5	2	195	1	0	0	0	0	0	0	1	0	13098	956	33	5	1265	5	RB1	13	48951053	Splice_Site	SNP	G	TCGA-27-2524-01A-01D-1494-08		48951053	66218825	49	13846											
LEO1	123169	broad.mit.edu	37	chr15	52258194	52258194	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctgaggcctctcctcatcaTctgtgttctgcattttctca	7	13	6	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr15:52258194T>C	uc002abo.2	-	2	582	c.566A>G	c.(565-567)GAT>GGT	p.D189G	LEO1_uc010bfd.2_Missense_Mutation_p.D189G	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	189	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		CTCCTCATCATCTGTGTTCTG	0.433													C	52258194	C	C	52258194	3	2	195	1	0	0	0	0	1	0	0	0	8726	1435	50	4	1478	4	LEO1	15	52258194	Missense_Mutation	SNP	T	TCGA-27-2524-01A-01D-1494-08		52258194	50273198	50	13847											
PDILT	204474	broad.mit.edu	37	chr16	20380898	20380898	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaggcattttgtacctggcGtcagagctcaagtttaggat	12	7	2	1	rs150342728	byFrequency	TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr16:20380898G>A	uc002dhc.1	-	8	1255	c.1032C>T	c.(1030-1032)GAC>GAT	p.D344D		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	344					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TGTACCTGGCGTCAGAGCTCA	0.468													A	20380898	A	A	20380898	2	1	195	1	0	0	0	0	0	0	0	1	11674	1136	40	1		1	PDILT	16	20380898	Silent	SNP	G	TCGA-27-2524-01A-01D-1494-08		20380898	69973855	51	13848											
CHD9	80205	broad.mit.edu	37	chr16	53330872	53330872	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atctgactcaaaatagatggAcaagaagagaagaagctgac	10	6	2	6			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr16:53330872A>G	uc002ehb.2	+	29	5679	c.5515A>G	c.(5515-5517)ACA>GCA	p.T1839A	CHD9_uc002egy.2_Missense_Mutation_p.T1839A|CHD9_uc002ehc.2_Missense_Mutation_p.T1839A|CHD9_uc002ehf.2_Missense_Mutation_p.T953A|CHD9_uc010cbw.2_Missense_Mutation_p.T207A	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1839					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				AAATAGATGGACAAGAAGAGA	0.294													G	53330872	G	G	53330872	3	3	195	1	0	0	0	0	1	0	0	0	3332	275	10	4	5629	4	CHD9	16	53330872	Missense_Mutation	SNP	A	TCGA-27-2524-01A-01D-1494-08	32949974	53330872	37023881	52	13849											
ZFHX3	463	broad.mit.edu	37	chr16	72827367	72827367	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgagccatcaactgacgtaCggtggctgggtcaaagtatt	12	8	2	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr16:72827367C>T	uc002fck.2	-	9	9887	c.9214G>A	c.(9214-9216)GTA>ATA	p.V3072I	ZFHX3_uc002fcl.2_Missense_Mutation_p.V2158I	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3072					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				AACTGACGTACGGTGGCTGGG	0.488													T	72827367	T	T	72827367	3	4	195	1	0	0	0	0	1	0	0	0	17631	536	19	1	1905	1	ZFHX3	16	72827367	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	19496495	72827367	17527386	53	13850											
RICH2	9912	broad.mit.edu	37	chr17	12847456	12847456	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	accatcagcggccgggagatCgccttccccatcgaggcgtg	13	15	1	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr17:12847456C>T	uc002gnr.3	+	10	1131	c.804C>T	c.(802-804)ATC>ATT	p.I268I	RICH2_uc010vvk.1_Silent_p.I268I|RICH2_uc010vvl.1_Silent_p.I268I|RICH2_uc002gns.3_Silent_p.I68I|RICH2_uc010vvm.1_Silent_p.I268I|RICH2_uc010vvn.1_RNA|RICH2_uc002gnt.1_5'UTR	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	268	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						GCCGGGAGATCGCCTTCCCCA	0.632													T	12847456	T	T	12847456	2	4	195	1	0	0	0	0	0	0	0	1	13357	874	31	2		2	RICH2	17	12847456	Silent	SNP	C	TCGA-27-2524-01A-01D-1494-08		12847456	68347754	54	13851											
CPD	1362	broad.mit.edu	37	chr17	28770823	28770823	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ccttgtacttaatccaggttCatcagggcgtcagaggattt	10	9	3	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr17:28770823C>A	uc002hfb.1	+	11	2392	c.2377C>A	c.(2377-2379)CAT>AAT	p.H793N	CPD_uc010wbo.1_Missense_Mutation_p.H546N|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	793	Extracellular (Potential).|Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						AATCCAGGTTCATCAGGGCGT	0.378													A	28770823	A	A	28770823	3	1	195	1	0	0	0	0	1	0	0	0	3798	826	29	5	2419	5	CPD	17	28770823	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	15923367	28770823	52424387	55	13852											
CPD	1362	broad.mit.edu	37	chr17	28770972	28770972	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gttccaggaacttataaaatCacagcatctgctcgagggtg	10	9	2	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr17:28770972C>G	uc002hfb.1	+	11	2541	c.2526C>G	c.(2524-2526)ATC>ATG	p.I842M	CPD_uc010wbo.1_Missense_Mutation_p.I595M|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	842	Extracellular (Potential).|Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						CTTATAAAATCACAGCATCTG	0.423													G	28770972	G	G	28770972	3	3	195	1	0	0	0	0	1	0	0	0	3798	816	29	5	2568	5	CPD	17	28770972	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	149	28770972	52424238	56	13853											
SLC4A1	6521	broad.mit.edu	37	chr17	42337808	42337808	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gggcccggagcagctcctctCggtcctgaggccggatctgg	16	14	2	1	rs55735880		TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr17:42337808C>T	uc002igf.3	-	6	598	c.449G>A	c.(448-450)CGA>CAA	p.R150Q	SLC4A1_uc002igg.3_Missense_Mutation_p.R150Q	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	150	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CAGCTCCTCTCGGTCCTGAGG	0.607													T	42337808	T	T	42337808	3	4	195	1	0	0	0	0	1	0	0	0	14650	884	31	2	2346	2	SLC4A1	17	42337808	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	13566836	42337808	38857402	57	13854											
GJC1	10052	broad.mit.edu	37	chr17	42882259	42882259	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gccttgttttgcttgtaggcGatcttagcattggacagttc	11	8	1	0	rs138440006		TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr17:42882259G>T	uc002ihj.2	-	2	1438	c.927C>A	c.(925-927)ATC>ATA	p.I309I	GJC1_uc002ihk.2_Silent_p.I309I|GJC1_uc002ihl.2_Silent_p.I309I|GJC1_uc010czx.2_Silent_p.I309I|GJC1_uc010czy.1_Silent_p.I170I	NM_005497	NP_005488	P36383	CXG1_HUMAN	connexin 45	309	Cytoplasmic (Potential).				cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane					0		Prostate(33;0.0959)				GCTTGTAGGCGATCTTAGCAT	0.507													T	42882259	T	T	42882259	2	4	195	1	0	0	0	0	0	0	0	1	6414	1048	37	5		5	GJC1	17	42882259	Silent	SNP	G	TCGA-27-2524-01A-01D-1494-08	544451	42882259	38312951	58	13855											
FMNL1	752	broad.mit.edu	37	chr17	43322740	43322740	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggagttcctgagggccaactCgcccaccatggacaagctgc	12	14	0	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr17:43322740C>T	uc002iin.2	+	22	3049	c.2849C>T	c.(2848-2850)TCG>TTG	p.S950L	FMNL1_uc002iiq.2_Missense_Mutation_p.S528L|FMNL1_uc010dag.2_RNA|LOC100133991_uc010dah.2_5'Flank	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	950	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						AGGGCCAACTCGCCCACCATG	0.617													T	43322740	T	T	43322740	3	4	195	1	0	0	0	0	1	0	0	0	5951	893	31	2	2935	2	FMNL1	17	43322740	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	440481	43322740	37872470	59	13856											
C17orf47	284083	broad.mit.edu	37	chr17	56621327	56621327	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	catagtgtccaggtcctgacTggagggagacagatcgaggg	16	8	0	3			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr17:56621327T>A	uc002iwq.1	-	1	357	c.221A>T	c.(220-222)CAG>CTG	p.Q74L		NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	74										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGTCCTGACTGGAGGGAGAC	0.567													A	56621327	A	A	56621327	3	1	195	1	0	0	0	0	1	0	0	0	1858	1580	55	5	1499	5	C17orf47	17	56621327	Missense_Mutation	SNP	T	TCGA-27-2524-01A-01D-1494-08	13298587	56621327	24573883	60	13857											
USP32	84669	broad.mit.edu	37	chr17	58258719	58258719	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gattataaataggcttaataCgagtatcttctctttggtca	7	6	3	0	rs17405739	by1000genomes	TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr17:58258719C>T	uc002iyo.1	-	32	4800	c.4514G>A	c.(4513-4515)CGT>CAT	p.R1505H	USP32_uc002iyn.1_Missense_Mutation_p.R1175H	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1505					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AGGCTTAATACGAGTATCTTC	0.383													T	58258719	T	T	58258719	3	4	195	1	0	0	0	0	1	0	0	0	17060	536	19	1	312	1	USP32	17	58258719	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	1637392	58258719	22936491	61	13858											
GAA	2548	broad.mit.edu	37	chr17	78081639	78081639	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctcaccctttctacctggCgctggaggacggcgggtcgg	15	13	2	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr17:78081639C>T	uc002jxo.2	+	6	1081	c.899C>T	c.(898-900)GCG>GTG	p.A300V	GAA_uc002jxp.2_Missense_Mutation_p.A300V|GAA_uc002jxq.2_Missense_Mutation_p.A300V	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	300					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	TTCTACCTGGCGCTGGAGGAC	0.647													T	78081639	T	T	78081639	3	4	195	1	0	0	0	0	1	0	0	0	6147	768	27	1	913	1	GAA	17	78081639	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	19822920	78081639	3113571	62	13859											
MUC16	94025	broad.mit.edu	37	chr19	9056586	9056586	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctccagtggtggcaaatgaaGtcatggcctctgatagagaa	12	8	2	3			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr19:9056586G>T	uc002mkp.2	-	3	31064	c.30860C>A	c.(30859-30861)ACT>AAT	p.T10287N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10289	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCAAATGAAGTCATGGCCTC	0.493													T	9056586	T	T	9056586	3	4	195	1	0	0	0	0	1	0	0	0	9973	1029	36	5	12991	5	MUC16	19	9056586	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08		9056586	50072397	63	13860											
NR1H2	7376	broad.mit.edu	37	chr19	50882004	50882004	+	Frame_Shift_Del	DEL	C	-	-													gatccagcagttggtggcggCccaactgcagtgcaacaaac							TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr19:50882004delC	uc010enw.2	+	7	977	c.701delC	c.(700-702)GCCfs	p.A234fs	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Frame_Shift_Del_p.A233fs|NR1H2_uc002psa.3_Frame_Shift_Del_p.A136fs	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	233	Ligand-binding (Potential).				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		TTGGTGGCGGCCCAACTGCAG	0.612													-	50882004	-	-	50882004	7	5	195	1	0	1	0	1	0	0	0	0	10617	739	26	0	712	0	NR1H2	19	50882004	Frame_Shift_Del	DEL	C	TCGA-27-2524-01A-01D-1494-08	41825418	50882004	8246979	64	13861											
SIRPG	55423	broad.mit.edu	37	chr20	1616837	1616837	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtgagggtcctctacctcGgatggcctcagacaagttgg	14	10	2	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr20:1616837G>A	uc002wfm.1	-	3	810	c.745C>T	c.(745-747)CGA>TGA	p.R249*	SIRPG_uc002wfn.1_Nonsense_Mutation_p.R249*|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	249	Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						CCTCTACCTCGGATGGCCTCA	0.622													A	1616837	A	A	1616837	4	1	195	1	0	0	0	0	0	1	0	0	14336	1124	39	2	430	2	SIRPG	20	1616837	Nonsense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08		1616837	61408683	65	13862											
PLK1S1	55857	broad.mit.edu	37	chr20	21143753	21143753	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgtattttgcaaaccctaagCtctcctgattcagaaaagga	7	9	2	2			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr20:21143753C>G	uc002wsb.2	+	6	1438	c.1305C>G	c.(1303-1305)AGC>AGG	p.S435R	PLK1S1_uc010zsh.1_Missense_Mutation_p.S332R|PLK1S1_uc010zsi.1_Missense_Mutation_p.S302R|PLK1S1_uc010zsj.1_RNA|uc002wsc.2_Intron|PLK1S1_uc002wsd.2_RNA	NM_018474	NP_060944	Q2M2Z5	KIZ_HUMAN	polo-like kinase 1 substrate 1 isoform 1	435					spindle organization	centrosome	protein kinase binding				0						AAACCCTAAGCTCTCCTGATT	0.368													G	21143753	G	G	21143753	3	3	195	1	0	0	0	0	1	0	0	0	12095	796	28	5	1327	5	PLK1S1	20	21143753	Missense_Mutation	SNP	C	TCGA-27-2524-01A-01D-1494-08	19526916	21143753	41881767	66	13863											
PYGB	5834	broad.mit.edu	37	chr20	25271172	25271172	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caagttggtcacctccatcgGcgacgtcgtcaatcatgacc	9	14	3	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr20:25271172G>T	uc002wup.2	+	16	1992	c.1883G>T	c.(1882-1884)GGC>GTC	p.G628V	uc010gdm.1_5'Flank	NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	628					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	ACCTCCATCGGCGACGTCGTC	0.522													T	25271172	T	T	25271172	3	4	195	1	0	0	0	0	1	0	0	0	12860	1203	42	5	1945	5	PYGB	20	25271172	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	4127419	25271172	37754348	67	13864											
SLC32A1	140679	broad.mit.edu	37	chr20	37356106	37356106	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gccccacagggcatgttcgtGctgggcctaccctacgccat	11	16	0	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr20:37356106G>C	uc002xjc.2	+	2	665	c.402G>C	c.(400-402)GTG>GTC	p.V134V		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	134	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GCATGTTCGTGCTGGGCCTAC	0.647													C	37356106	C	C	37356106	2	2	195	1	0	0	0	0	0	0	0	1	14565	1306	46	5		5	SLC32A1	20	37356106	Silent	SNP	G	TCGA-27-2524-01A-01D-1494-08	12084934	37356106	25669414	68	13865											
CASS4	57091	broad.mit.edu	37	chr20	55033502	55033502	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggggcgctcttcaaagccaTcagcgcatttcacggcagcc	11	14	4	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr20:55033502T>A	uc002xxp.2	+	7	2285	c.2060T>A	c.(2059-2061)ATC>AAC	p.I687N	CASS4_uc002xxr.2_Missense_Mutation_p.I687N|CASS4_uc010zze.1_Missense_Mutation_p.I633N|CASS4_uc010gio.2_Missense_Mutation_p.I250N	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	687					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						TTCAAAGCCATCAGCGCATTT	0.577													A	55033502	A	A	55033502	3	1	195	1	0	0	0	0	1	0	0	0	2683	1435	50	5	2082	5	CASS4	20	55033502	Missense_Mutation	SNP	T	TCGA-27-2524-01A-01D-1494-08	17677396	55033502	7992018	69	13866											
SLCO4A1	28231	broad.mit.edu	37	chr20	61288142	61288142	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgttcttcctgtgtgcggcCgcattcctgcaggggatgac	13	12	1	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr20:61288142C>T	uc002ydb.1	+	2	541	c.336C>T	c.(334-336)GCC>GCT	p.A112A	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	112	Helical; Name=1; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			TGTGTGCGGCCGCATTCCTGC	0.647													T	61288142	T	T	61288142	2	4	195	1	0	0	0	0	0	0	0	1	14729	639	23	2		2	SLCO4A1	20	61288142	Silent	SNP	C	TCGA-27-2524-01A-01D-1494-08	6254640	61288142	1737378	70	13867											
POTEH	23784	broad.mit.edu	37	chr22	16287657	16287657	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaagtgcccacgttgctctTgccgctccccctgcaccagg	10	17	1	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr22:16287657T>C	uc010gqp.2	-	1	281	c.229A>G	c.(229-231)AAG>GAG	p.K77E	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	77										skin(1)	1						ACGTTGCTCTTGCCGCTCCCC	0.587													C	16287657	C	C	16287657	3	2	195	1	0	0	0	0	1	0	0	0	12267	1821	63	4	1448	4	POTEH	22	16287657	Missense_Mutation	SNP	T	TCGA-27-2524-01A-01D-1494-08		16287657	35016909	71	13868											
ELFN2	114794	broad.mit.edu	37	chr22	37769172	37769172	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggatgtcatgcagatcctcGtccttggcgaactggacctt	11	11	1	1			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chr22:37769172G>A	uc003asq.3	-	3	3189	c.2403C>T	c.(2401-2403)GAC>GAT	p.D801D		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	801	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					GCAGATCCTCGTCCTTGGCGA	0.632													A	37769172	A	A	37769172	2	1	195	1	0	0	0	0	0	0	0	1	5058	1136	40	1		1	ELFN2	22	37769172	Silent	SNP	G	TCGA-27-2524-01A-01D-1494-08	21481515	37769172	13535394	72	13869											
RIBC1	158787	broad.mit.edu	37	chrX	53455349	53455349	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gagcagaagcagcagctcaaGaacgggcgtgaatttagtct	13	8	2	3			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chrX:53455349G>A	uc004dsk.2	+	5	471	c.318G>A	c.(316-318)AAG>AAA	p.K106K	RIBC1_uc004dsj.1_Silent_p.K106K|RIBC1_uc011mog.1_Intron	NM_001031745	NP_001026915	Q8N443	RIBC1_HUMAN	RIB43A domain with coiled-coils 1 isoform 1	106	Potential.										0						AGCAGCTCAAGAACGGGCGTG	0.512													A	53455349	A	A	53455349	2	1	195	1	0	0	0	0	0	0	0	1	13352	933	33	3		3	RIBC1	23	53455349	Silent	SNP	G	TCGA-27-2524-01A-01D-1494-08		53455349	101815211	73	13870											
CT45A5	441521	broad.mit.edu	37	chrX	134947910	134947910	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcttacactacttacttcGtccaaggcatcggatttcct	6	12	1	0	rs146235294	byFrequency	TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chrX:134947910G>A	uc004eze.2	-	3	660	c.415C>T	c.(415-417)CGA>TGA	p.R139*	CT45A5_uc011mvu.1_Nonsense_Mutation_p.R139*	NM_001007551	NP_001007552	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	139											0						TACTTACTTCGTCCAAGGCAT	0.383													A	134947910	A	A	134947910	4	1	195	1	0	0	0	0	0	1	0	0	3988	1153	40	1	166	1	CT45A5	23	134947910	Nonsense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	81492561	134947910	20322650	74	13871											
AFF2	2334	broad.mit.edu	37	chrX	148069012	148069012	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accacatggctgccagccacGtcaacatcactagcaatgtg	8	14	2	0			TCGA-27-2524-01A-01D-1494-08	TCGA-27-2524-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	ce679bfd-fbf9-4c78-822e-37d2322d544b	30a97718-a630-4552-89c0-e2fe8af1d1a2	g.chrX:148069012G>A	uc004fcp.2	+	20	4218	c.3739G>A	c.(3739-3741)GTC>ATC	p.V1247I	AFF2_uc004fcq.2_Missense_Mutation_p.V1237I|AFF2_uc004fcr.2_Missense_Mutation_p.V1208I|AFF2_uc011mxb.1_Missense_Mutation_p.V1212I|AFF2_uc004fcs.2_Missense_Mutation_p.V1212I|AFF2_uc011mxc.1_Missense_Mutation_p.V888I	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1247					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TGCCAGCCACGTCAACATCAC	0.498													A	148069012	A	A	148069012	3	1	195	1	0	0	0	0	1	0	0	0	357	1145	40	1	3872	1	AFF2	23	148069012	Missense_Mutation	SNP	G	TCGA-27-2524-01A-01D-1494-08	13121102	148069012	7201548	75	13872											
PRAMEF2	65122	broad.mit.edu	37	chr1	12919829	12919829	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taagctggtcaattatctaaCgccaattaaatatctcagaa	5	8	3	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr1:12919829C>T	uc001aum.1	+	3	656	c.569C>T	c.(568-570)ACG>ATG	p.T190M		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	190											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AATTATCTAACGCCAATTAAA	0.398													T	12919829	T	T	12919829	3	4	196	1	0	0	0	0	1	0	0	0	12435	536	19	1	575	1	PRAMEF2	1	12919829	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08		12919829	236330792	1	13873											
ATP13A2	23400	broad.mit.edu	37	chr1	17318252	17318252	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaccatgacggcgcggatgCgggtccttcgcagagcctgg	15	13	1	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr1:17318252C>T	uc001baa.2	-	20	2418	c.2228G>A	c.(2227-2229)CGC>CAC	p.R743H	ATP13A2_uc001azz.1_5'Flank|ATP13A2_uc001bab.2_Missense_Mutation_p.R738H|ATP13A2_uc001bac.2_Missense_Mutation_p.R738H	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	743	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		GGCGCGGATGCGGGTCCTTCG	0.622													T	17318252	T	T	17318252	3	4	196	1	0	0	0	0	1	0	0	0	1124	768	27	1	1590	1	ATP13A2	1	17318252	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	4398423	17318252	231932369	2	13874											
WDR78	79819	broad.mit.edu	37	chr1	67301450	67301450	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catatggactctgataaataCgttctggccactaaatttta	6	8	2	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr1:67301450C>T	uc001dcx.2	-	11	1648	c.1592G>A	c.(1591-1593)CGT>CAT	p.R531H	WDR78_uc009waw.2_Missense_Mutation_p.R277H|WDR78_uc009wax.2_Intron	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	531										ovary(2)	2						CTGATAAATACGTTCTGGCCA	0.368													T	67301450	T	T	67301450	3	4	196	1	0	0	0	0	1	0	0	0	17325	536	19	1	982	1	WDR78	1	67301450	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	49983198	67301450	181949171	3	13875											
CELSR2	1952	broad.mit.edu	37	chr1	109795999	109795999	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctggaggccatcatgagcGtgctggtgtcaggtaaggaa	15	8	3	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr1:109795999G>A	uc001dxa.3	+	1	3359	c.3298G>A	c.(3298-3300)GTG>ATG	p.V1100M		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1100	Cadherin 9.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CATCATGAGCGTGCTGGTGTC	0.637													A	109795999	A	A	109795999	3	1	196	1	0	0	0	0	1	0	0	0	3222	1145	40	1	3300	1	CELSR2	1	109795999	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08	42494549	109795999	139454622	4	13876											
HRNR	388697	broad.mit.edu	37	chr1	152191194	152191194	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tgagctagatccatgttgttCgctcctagatgactgtcctg	10	10	0	4			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr1:152191194C>G	uc001ezt.1	-	3	2987	c.2911G>C	c.(2911-2913)GAA>CAA	p.E971Q		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	971	11.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGTTGTTCGCTCCTAGAT	0.562													G	152191194	G	G	152191194	3	3	196	1	0	0	0	0	1	0	0	0	7359	893	31	5	5645	5	HRNR	1	152191194	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	42395195	152191194	97059427	5	13877											
CD5L	922	broad.mit.edu	37	chr1	157804375	157804375	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtcagtacagccctcccacaTcccagctgccggcacaccac	7	20	1	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr1:157804375T>C	uc001frk.3	-	4	683	c.540A>G	c.(538-540)GGA>GGG	p.G180G		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	180	SRCR 2.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCCTCCCACATCCCAGCTGCC	0.587													C	157804375	C	C	157804375	2	2	196	1	0	0	0	0	0	0	0	1	3027	1422	50	4		4	CD5L	1	157804375	Silent	SNP	T	TCGA-27-2526-01A-01D-1494-08	5613181	157804375	91446246	6	13878											
CEP350	9857	broad.mit.edu	37	chr1	180063502	180063505	+	Frame_Shift_Del	DEL	GACA	-	-													ctggaaaaaatcagcttactGacagacagtttactaaaagt							TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr1:180063502_180063505delGACA	uc001gnt.2	+	34	8645_8648	c.8262_8265delGACA	c.(8260-8265)CTGACAfs	p.L2754fs	CEP350_uc009wxl.2_Frame_Shift_Del_p.L2753fs|CEP350_uc001gnv.2_Frame_Shift_Del_p.L889fs|CEP350_uc001gnw.1_Frame_Shift_Del_p.L511fs|CEP350_uc001gnx.1_Frame_Shift_Del_p.L511fs	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2754_2755						centrosome|nucleus|spindle				ovary(4)	4						TCAGCTTACTGACAGACAGTTTAC	0.358													-	180063505	-	-	180063502	7	5	196	1	0	1	0	1	0	0	0	0	3254	1277	45	0	8392	0	CEP350	1	180063502	Frame_Shift_Del	DEL	GACA	TCGA-27-2526-01A-01D-1494-08	22259127	180063502	69187119	7	13879											
SLC5A6	8884	broad.mit.edu	37	chr2	27425742	27425742	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctagacaaagcagcccatagCcaaaggctgggggaaaagga	13	9	0	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr2:27425742C>T	uc002rjd.2	-	12	1605	c.1214G>A	c.(1213-1215)GGC>GAC	p.G405D	SLC5A6_uc010eyv.1_Missense_Mutation_p.G405D	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	405	Helical; (Potential).				biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	CAGCCCATAGCCAAAGGCTGG	0.493													T	27425742	T	T	27425742	3	4	196	1	0	0	0	0	1	0	0	0	14669	739	26	3	717	3	SLC5A6	2	27425742	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08		27425742	215773631	8	13880											
SLC1A4	6509	broad.mit.edu	37	chr2	65237852	65237852	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agacctcatccgtttcttcaAttccctcaacgaggcgacga	7	14	4	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr2:65237852A>G	uc010yqa.1	+	4	1077	c.755A>G	c.(754-756)AAT>AGT	p.N252S	SLC1A4_uc010ypy.1_Missense_Mutation_p.N32S|SLC1A4_uc010ypz.1_Missense_Mutation_p.N32S|SLC1A4_uc010fcv.2_Missense_Mutation_p.N252S|SLC1A4_uc002sdh.2_Missense_Mutation_p.N32S	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	252					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	CGTTTCTTCAATTCCCTCAAC	0.498													G	65237852	G	G	65237852	3	3	196	1	0	0	0	0	1	0	0	0	14434	101	4	4	769	4	SLC1A4	2	65237852	Missense_Mutation	SNP	A	TCGA-27-2526-01A-01D-1494-08	37812110	65237852	177961521	9	13881											
GPR45	11250	broad.mit.edu	37	chr2	105858641	105858641	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggggaccacttctgccgccTctcagccacgctctactggt	10	16	3	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr2:105858641T>C	uc002tco.1	+	1	442	c.326T>C	c.(325-327)CTC>CCC	p.L109P		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	109	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TTCTGCCGCCTCTCAGCCACG	0.612													C	105858641	C	C	105858641	3	2	196	1	0	0	0	0	1	0	0	0	6696	1551	54	4	328	4	GPR45	2	105858641	Missense_Mutation	SNP	T	TCGA-27-2526-01A-01D-1494-08	40620789	105858641	137340732	10	13882											
NDUFA10	4705	broad.mit.edu	37	chr2	240944658	240944658	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtggtataaagtgcgattgtCctgcttgagccacggccctt	12	10	0	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr2:240944658C>T	uc002vyn.2	-	8	939	c.859G>A	c.(859-861)GAC>AAC	p.D287N	NDUFA10_uc010fzc.1_Missense_Mutation_p.D317N	NM_004544	NP_004535	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	287					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)	1		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	GTGCGATTGTCCTGCTTGAGC	0.463													T	240944658	T	T	240944658	3	4	196	1	0	0	0	0	1	0	0	0	10260	855	30	3	220	3	NDUFA10	2	240944658	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	135086017	240944658	2254715	11	13883											
DPPA2	151871	broad.mit.edu	37	chr3	109026881	109026881	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctttaaggttgatcttaccaGaggcttgcatcaaaaaggcc	9	9	2	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr3:109026881G>A	uc003dxo.2	-	6	903	c.656C>T	c.(655-657)TCT>TTT	p.S219F		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	219						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						GATCTTACCAGAGGCTTGCAT	0.438													A	109026881	A	A	109026881	3	1	196	1	0	0	0	0	1	0	0	0	4734	942	33	3	252	3	DPPA2	3	109026881	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08		109026881	88995549	12	13884											
CD200R1L	344807	broad.mit.edu	37	chr3	112546470	112546470	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attatgatcaaatttcttaaTgcgataggagggcaacaaag	9	5	2	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr3:112546470T>C	uc003dzi.1	-	3	400	c.174A>G	c.(172-174)GCA>GCG	p.A58A	CD200R1L_uc011bhw.1_Silent_p.A37A|CD200R1L_uc010hqf.1_Silent_p.A37A	NM_001008784	NP_001008784	Q6Q8B3	MO2R2_HUMAN	CD200 cell surface glycoprotein receptor 2	58	Ig-like V-type.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)	1						AATTTCTTAATGCGATAGGAG	0.393													C	112546470	C	C	112546470	2	2	196	1	0	0	0	0	0	0	0	1	2982	1451	51	4		4	CD200R1L	3	112546470	Silent	SNP	T	TCGA-27-2526-01A-01D-1494-08	3519589	112546470	85475960	13	13885											
RNF168	165918	broad.mit.edu	37	chr3	196230195	196230195	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaacaggagcatccaacaCgtcttgaagcaaaaaggcgc	11	10	1	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr3:196230195C>T	uc003fwq.2	-	1	388	c.-150G>A	c.(-152--148)ACGTG>ACATG		RNF168_uc010iah.2_Translation_Start_Site	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168						double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		GCATCCAACACGTCTTGAAGC	0.493													T	196230195	T	T	196230195	1	4	196	1	0	0	0	0	0	0	0	0	13459	551	19	1		1	RNF168	3	196230195	Translation_Start_Site	SNP	C	TCGA-27-2526-01A-01D-1494-08	83683725	196230195	1792235	14	13886											
HGFAC	3083	broad.mit.edu	37	chr4	3451018	3451018	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acggcgtggcttacctctacGgcatcatcagctggggtgac	13	12	3	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr4:3451018G>A	uc003ghc.2	+	14	1843	c.1840G>A	c.(1840-1842)GGC>AGC	p.G614S	HGFAC_uc010icw.2_Missense_Mutation_p.G621S	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	614	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TTACCTCTACGGCATCATCAG	0.672													A	3451018	A	A	3451018	3	1	196	1	0	0	0	0	1	0	0	0	7086	1116	39	2	1894	2	HGFAC	4	3451018	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08		3451018	187703258	15	13887											
RBM47	54502	broad.mit.edu	37	chr4	40439840	40439840	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgcgttgtaggggtagccGtagtaggccagtgtgtaggg	19	6	0	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr4:40439840G>A	uc003gvc.2	-	4	1781	c.1071C>T	c.(1069-1071)TAC>TAT	p.Y357Y	RBM47_uc003gvd.2_Silent_p.Y357Y|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Silent_p.Y319Y|RBM47_uc003gvg.1_Silent_p.Y357Y	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	357						nucleus	nucleotide binding|RNA binding			breast(3)	3						AGGGGTAGCCGTAGTAGGCCA	0.642													A	40439840	A	A	40439840	2	1	196	1	0	0	0	0	0	0	0	1	13141	1140	40	1		1	RBM47	4	40439840	Silent	SNP	G	TCGA-27-2526-01A-01D-1494-08	36988822	40439840	150714436	16	13888											
ANK2	287	broad.mit.edu	37	chr4	114276299	114276299	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtactcactagtcctttcaaCacaacatttccactcgacta	3	14	2	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr4:114276299C>G	uc003ibe.3	+	38	6625	c.6525C>G	c.(6523-6525)AAC>AAG	p.N2175K	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.N2190K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2142					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GTCCTTTCAACACAACATTTC	0.433													G	114276299	G	G	114276299	3	3	196	1	0	0	0	0	1	0	0	0	621	477	17	5	6740	5	ANK2	4	114276299	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	73836459	114276299	76877977	17	13889											
DNAH5	1767	broad.mit.edu	37	chr5	13876806	13876806	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gacatacctttttggtggagTtgataattgtgctaagcaca	10	6	0	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr5:13876806T>A	uc003jfd.2	-	22	3425	c.3383A>T	c.(3382-3384)AAC>ATC	p.N1128I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1128	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTTGGTGGAGTTGATAATTGT	0.378									Kartagener_syndrome				A	13876806	A	A	13876806	3	1	196	1	0	0	0	0	1	0	0	0	4604	1725	60	5	10723	5	DNAH5	5	13876806	Missense_Mutation	SNP	T	TCGA-27-2526-01A-01D-1494-08		13876806	167038454	18	13890											
C6	729	broad.mit.edu	37	chr5	41186199	41186199	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgacattttccagattggcCggaacacggtatggattact	10	10	0	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr5:41186199C>T	uc003jmk.2	-	6	909	c.699G>A	c.(697-699)CCG>CCA	p.P233P	C6_uc003jml.1_Silent_p.P233P	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	233	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CCAGATTGGCCGGAACACGGT	0.443													T	41186199	T	T	41186199	2	4	196	1	0	0	0	0	0	0	0	1	2315	639	23	2		2	C6	5	41186199	Silent	SNP	C	TCGA-27-2526-01A-01D-1494-08	27309393	41186199	139729061	19	13891											
PCDHB7	56129	broad.mit.edu	37	chr5	140554315	140554315	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaggctgctgagcgagcgCgacgcagccaagcagaggct	16	13	0	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr5:140554315C>T	uc003lit.2	+	1	2073	c.1899C>T	c.(1897-1899)CGC>CGT	p.R633R		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	633	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAGCGAGCGCGACGCAGCCA	0.687													T	140554315	T	T	140554315	2	4	196	1	0	0	0	0	0	0	0	1	11547	755	27	1		1	PCDHB7	5	140554315	Silent	SNP	C	TCGA-27-2526-01A-01D-1494-08	99368116	140554315	40360945	20	13892											
SH3TC2	79628	broad.mit.edu	37	chr5	148407984	148407984	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggctccggcaggcgatagctGtctgaggtggccgagaggag	19	9	1	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr5:148407984G>C	uc003lpu.2	-	11	1463	c.1311C>G	c.(1309-1311)GAC>GAG	p.D437E	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.D81E|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Missense_Mutation_p.D430E|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_Missense_Mutation_p.D322E	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	437							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGATAGCTGTCTGAGGTGG	0.622													C	148407984	C	C	148407984	3	2	196	1	0	0	0	0	1	0	0	0	14262	1368	48	5	2583	5	SH3TC2	5	148407984	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08	7853669	148407984	32507276	21	13893											
GABRB2	2561	broad.mit.edu	37	chr5	160761758	160761758	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcagtaataaaatggcctaCctaatgccacccttgcagct	7	12	0	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr5:160761758C>T	uc003lys.1	-	8	1050	c.832_splice	c.e8+1	p.G278_splice	GABRB2_uc011deh.1_Splice_Site_p.G117_splice|GABRB2_uc003lyr.1_Splice_Site_p.G278_splice|GABRB2_uc003lyt.1_Splice_Site_p.G278_splice|GABRB2_uc010jiu.1_Splice_Site_p.G215_splice	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta						gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AAATGGCCTACCTAATGCCAC	0.443													T	160761758	T	T	160761758	5	4	196	1	0	0	0	0	0	0	1	0	6167	521	18	3	721	3	GABRB2	5	160761758	Splice_Site	SNP	C	TCGA-27-2526-01A-01D-1494-08	12353774	160761758	20153502	22	13894											
GABRA6	2559	broad.mit.edu	37	chr5	161117359	161117359	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccagcaagaactgtttttGgtatatgtcacattttgtac	7	8	1	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr5:161117359G>A	uc003lyu.2	+	7	1164	c.826G>A	c.(826-828)GGG>AGG	p.G276R	GABRA6_uc003lyv.2_Missense_Mutation_p.G47R	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	276	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AACTGTTTTTGGTATATGTCA	0.378										TCGA Ovarian(5;0.080)			A	161117359	A	A	161117359	3	1	196	1	0	0	0	0	1	0	0	0	6165	1362	47	3	852	3	GABRA6	5	161117359	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08	355601	161117359	19797901	23	13895											
HIST1H1C	3006	broad.mit.edu	37	chr6	26056237	26056245	+	In_Frame_Del	DEL	CTTCTTGGG	-	-													ggagttgcgccgccagccgcCttcttgggcttcttggctgc					rs149712381	by1000genomes	TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr6:26056237_26056245delCTTCTTGGG	uc003nfw.2	-	1	455_463	c.412_420delCCCAAGAAG	c.(412-420)CCCAAGAAGdel	p.PKK138del		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	138_140					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						CGCCAGCCGCCTTCTTGGGCTTCTTGGCT	0.565													-	26056245	-	-	26056237	7	5	196	1	0	1	0	1	0	0	0	0	7124	680	24	0	225	0	HIST1H1C	6	26056237	In_Frame_Del	DEL	CTTCTTGGG	TCGA-27-2526-01A-01D-1494-08		26056237	145058830	24	13896											
TAP2	6891	broad.mit.edu	37	chr6	32803482	32803482	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggaggagaaaagctgctccCggatccgcaagttgattcga	14	9	0	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr6:32803482C>T	uc003occ.2	-	3	708	c.677G>A	c.(676-678)CGG>CAG	p.R226Q	TAP2_uc011dqf.1_Missense_Mutation_p.R226Q|TAP2_uc003ocb.1_Missense_Mutation_p.R226Q|TAP2_uc003ocd.2_Missense_Mutation_p.R226Q	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	226	Cytoplasmic (Potential).|ABC transmembrane type-1.				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						AAGCTGCTCCCGGATCCGCAA	0.582													T	32803482	T	T	32803482	3	4	196	1	0	0	0	0	1	0	0	0	15548	652	23	2	1504	2	TAP2	6	32803482	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	6747245	32803482	138311585	25	13897											
DNAH8	1769	broad.mit.edu	37	chr6	38750809	38750809	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacattttatcaagtccggaCggtaaagctgtcatccgtca	9	10	3	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr6:38750809C>T	uc003ooe.1	+	15	2238	c.1638C>T	c.(1636-1638)GAC>GAT	p.D546D		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAAGTCCGGACGGTAAAGCTG	0.378													T	38750809	T	T	38750809	2	4	196	1	0	0	0	0	0	0	0	1	4607	535	19	1		1	DNAH8	6	38750809	Silent	SNP	C	TCGA-27-2526-01A-01D-1494-08	5947327	38750809	132364258	26	13898											
MANEA	79694	broad.mit.edu	37	chr6	96053740	96053740	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaatgggccaatctgttaaCcacctcagggtctcggagta	10	10	3	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr6:96053740C>T	uc003poo.1	+	5	988	c.848C>T	c.(847-849)ACC>ATC	p.T283I		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	283	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		AATCTGTTAACCACCTCAGGG	0.398													T	96053740	T	T	96053740	3	4	196	1	0	0	0	0	1	0	0	0	9221	507	18	3	862	3	MANEA	6	96053740	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	57302931	96053740	75061327	27	13899											
SIM1	6492	broad.mit.edu	37	chr6	100841630	100841630	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccgaaaactgtctgtaggCgcacgatgcgtcgtgctggg	15	10	1	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr6:100841630C>T	uc003pqj.3	-	10	1510	c.1303G>A	c.(1303-1305)GCC>ACC	p.A435T	SIM1_uc010kcu.2_Missense_Mutation_p.A435T	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	435	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TGTCTGTAGGCGCACGATGCG	0.617													T	100841630	T	T	100841630	3	4	196	1	0	0	0	0	1	0	0	0	14323	768	27	1	1005	1	SIM1	6	100841630	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	4787890	100841630	70273437	28	13900											
CALCR	799	broad.mit.edu	37	chr7	93108720	93108720	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcatagcatttgtactgtgCatccatcatcttctttcgtc	6	11	4	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr7:93108720C>T	uc003umv.1	-	4	466	c.205G>A	c.(205-207)GCA>ACA	p.A69T	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.A51T|CALCR_uc003umw.2_Missense_Mutation_p.A51T	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	51	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TTGTACTGTGCATCCATCATC	0.418													T	93108720	T	T	93108720	3	4	196	1	0	0	0	0	1	0	0	0	2579	710	25	3	1369	3	CALCR	7	93108720	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08		93108720	66029943	29	13901											
TMEM130	222865	broad.mit.edu	37	chr7	98457803	98457803	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaggggtaaggacctaccCgtccccgaagtcccagctgt	12	14	0	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr7:98457803C>T	uc003upo.2	-	3	739	c.550G>A	c.(550-552)GGG>AGG	p.G184R	TMEM130_uc011kiq.1_Missense_Mutation_p.G165R|TMEM130_uc011kir.1_Missense_Mutation_p.G184R|TMEM130_uc003upn.2_Missense_Mutation_p.G82R	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	184	Extracellular (Potential).|PKD.					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGGACCTACCCGTCCCCGAAG	0.557													T	98457803	T	T	98457803	3	4	196	1	0	0	0	0	1	0	0	0	16040	666	23	2	781	2	TMEM130	7	98457803	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	5349083	98457803	60680860	30	13902											
LAMB4	22798	broad.mit.edu	37	chr7	107745023	107745023	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tccttgcatctctcacagttCggaccatctgtattgtgctg	8	12	3	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr7:107745023C>T	uc010ljo.1	-	9	996	c.912G>A	c.(910-912)CCG>CCA	p.P304P	LAMB4_uc003vey.2_Silent_p.P304P	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	304	Laminin EGF-like 1.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TCTCACAGTTCGGACCATCTG	0.522													T	107745023	T	T	107745023	2	4	196	1	0	0	0	0	0	0	0	1	8613	871	31	2		2	LAMB4	7	107745023	Silent	SNP	C	TCGA-27-2526-01A-01D-1494-08	9287220	107745023	51393640	31	13903											
UBE3C	9690	broad.mit.edu	37	chr7	157041080	157041081	+	In_Frame_Ins	INS	-	TGG	TGG													ggctctctatgagaacatgcINStggtggagctgccctttgca							TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr7:157041080_157041081insTGG	uc010lqs.2	+	19	2812_2813	c.2500_2501insTGG	c.(2500-2502)CTG>CTGGTG	p.835_836insV	UBE3C_uc003wni.3_In_Frame_Ins_p.198_199insV	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	835_836	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TGAGAACATGCTGGTGGAGCTG	0.47													TGG	157041081	TGG	TGG	157041080	7	5	196	1	0	1	1	0	0	0	0	0	16878	796	28	0	2574	0	UBE3C	7	157041080	In_Frame_Ins	INS	-	TCGA-27-2526-01A-01D-1494-08	49296057	157041080	2097583	32	13904											
RP1L1	94137	broad.mit.edu	37	chr8	10467799	10467799	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcttcatcctcattggtgGcacaagcgcaggctcgggcg	13	13	2	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr8:10467799G>A	uc003wtc.2	-	4	4038	c.3809C>T	c.(3808-3810)GCC>GTC	p.A1270V		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1270					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTCATTGGTGGCACAAGCGCA	0.517													A	10467799	A	A	10467799	3	1	196	1	0	0	0	0	1	0	0	0	13533	1203	42	3	3397	3	RP1L1	8	10467799	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08		10467799	135896223	33	13905											
CSMD3	114788	broad.mit.edu	37	chr8	113420591	113420591	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tagctgttattggtccaactGaagtaaatcgaattgtgatc	9	6	0	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr8:113420591G>T	uc003ynu.2	-	34	5720	c.5561C>A	c.(5560-5562)TCA>TAA	p.S1854*	CSMD3_uc003yns.2_Intron|CSMD3_uc003ynt.2_Nonsense_Mutation_p.S1814*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.S1750*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1854	Extracellular (Potential).|CUB 10.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGGTCCAACTGAAGTAAATCG	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			T	113420591	T	T	113420591	4	4	196	1	0	0	0	0	0	1	0	0	3946	1294	45	5	5714	5	CSMD3	8	113420591	Nonsense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08	102952792	113420591	32943431	34	13906											
MAT1A	4143	broad.mit.edu	37	chr10	82034790	82034790	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctggacaagcactctccGgcagagccctgctttcacca	8	16	2	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr10:82034790G>A	uc001kbw.2	-	7	1189	c.934C>T	c.(934-936)CGG>TGG	p.R312W		NM_000429	NP_000420	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	312					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	AGCACTCTCCGGCAGAGCCCT	0.632													A	82034790	A	A	82034790	3	1	196	1	0	0	0	0	1	0	0	0	9329	1115	39	2	265	2	MAT1A	10	82034790	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08		82034790	53499957	35	13907											
PTEN	5728	broad.mit.edu	37	chr10	89692923	89692923	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgaactggtgtaatgatatGtgcatatttattacatcggg	10	5	0	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr10:89692923G>A	uc001kfb.2	+	6	1438	c.407G>A	c.(406-408)TGT>TAT	p.C136Y		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	136	Phosphatase tensin-type.		C -> Y (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P3).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.C136Y(7)|p.R55fs*1(4)|p.C136F(3)|p.C136fs*1(2)|p.C136R(2)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.I135_A137>T(1)|p.A121_F145del(1)|p.I135fs*6(1)|p.C136_A137insGM(1)|p.C136W(1)|p.T131fs*42(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GTAATGATATGTGCATATTTA	0.393		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89692923	A	A	89692923	3	1	196	1	0	0	0	0	1	0	0	0	12738	1377	48	3	425	3	PTEN	10	89692923	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08	7658133	89692923	45841824	36	13908											
OR9G4	283189	broad.mit.edu	37	chr11	56510803	56510803	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaaatcctcctatgtaggagCcagcaacaagcccagtacag	8	12	0	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr11:56510803C>A	uc010rjo.1	-	1	485	c.485G>T	c.(484-486)GGC>GTC	p.G162V		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	162	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TATGTAGGAGCCAGCAACAAG	0.463													A	56510803	A	A	56510803	3	1	196	1	0	0	0	0	1	0	0	0	11251	739	26	5	501	5	OR9G4	11	56510803	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08		56510803	78495713	37	13909											
TECTA	7007	broad.mit.edu	37	chr11	121028677	121028677	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcgcaacggggtgcgcgGctgcttcagcaccaagacct	14	14	1	1			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr11:121028677G>A	uc010rzo.1	+	13	4433	c.4433G>A	c.(4432-4434)GGC>GAC	p.G1478D		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1478					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGGGTGCGCGGCTGCTTCAGC	0.682													A	121028677	A	A	121028677	3	1	196	1	0	0	0	0	1	0	0	0	15744	1203	42	3	4483	3	TECTA	11	121028677	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08	64517874	121028677	13977839	38	13910											
LRIG3	121227	broad.mit.edu	37	chr12	59270251	59270251	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actgtcatgttgtggtaagaAaaatccagcacctgaagatg	10	7	1	3			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr12:59270251A>G	uc001sqr.2	-	16	2917	c.2671T>C	c.(2671-2673)TTC>CTC	p.F891L	LRIG3_uc009zqh.2_Missense_Mutation_p.F831L|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	891						integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			TGTGGTAAGAAAAATCCAGCA	0.418													G	59270251	G	G	59270251	3	3	196	1	0	0	0	0	1	0	0	0	8946	14	1	4	704	4	LRIG3	12	59270251	Missense_Mutation	SNP	A	TCGA-27-2526-01A-01D-1494-08		59270251	74581644	39	13911											
LRIG3	121227	broad.mit.edu	37	chr12	59271192	59271192	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtttacacacctgtgttggtAatgctgcaatcttcattcct	7	10	2	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr12:59271192A>G	uc001sqr.2	-	15	2772	c.2526T>C	c.(2524-2526)ATT>ATC	p.I842I	LRIG3_uc009zqh.2_Silent_p.I782I|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	842						integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			CTGTGTTGGTAATGCTGCAAT	0.493													G	59271192	G	G	59271192	2	3	196	1	0	0	0	0	0	0	0	1	8946	358	13	4		4	LRIG3	12	59271192	Silent	SNP	A	TCGA-27-2526-01A-01D-1494-08	941	59271192	74580703	40	13912											
PLBD2	196463	broad.mit.edu	37	chr12	113825637	113825637	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atgctatctccgcccgctccGacctcaacccggccaatggc	8	19	2	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr12:113825637G>A	uc001tve.2	+	11	1563	c.1528G>A	c.(1528-1530)GAC>AAC	p.D510N	PLBD2_uc001tvf.2_Missense_Mutation_p.D478N	NM_173542	NP_775813	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2 isoform 1	510					lipid catabolic process	lysosomal lumen	hydrolase activity				0						CGCCCGCTCCGACCTCAACCC	0.617													A	113825637	A	A	113825637	3	1	196	1	0	0	0	0	1	0	0	0	12026	1058	37	2	1570	2	PLBD2	12	113825637	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08	54554445	113825637	20026258	41	13913											
ZMYM2	7750	broad.mit.edu	37	chr13	20625722	20625722	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgacaactcagaaaggaccTgaaaacttacattatggtat	7	7	1	3			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr13:20625722T>C	uc001umr.2	+	14	2740	c.2442T>C	c.(2440-2442)CCT>CCC	p.P814P	ZMYM2_uc001ums.2_Silent_p.P814P|ZMYM2_uc001umt.2_Silent_p.P814P|ZMYM2_uc010tco.1_RNA|ZMYM2_uc001umv.2_Silent_p.P194P|ZMYM2_uc001umw.2_Silent_p.P267P	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	814					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		AGAAAGGACCTGAAAACTTAC	0.368													C	20625722	C	C	20625722	2	2	196	1	0	0	0	0	0	0	0	1	17697	1567	55	4		4	ZMYM2	13	20625722	Silent	SNP	T	TCGA-27-2526-01A-01D-1494-08		20625722	94544156	42	13914											
GALC	2581	broad.mit.edu	37	chr14	88416243	88416243	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcggatgtttttccaagtttGgtataccatacctgtagctc	8	9	0	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr14:88416243G>T	uc001xvt.2	-	12	1683	c.1284C>A	c.(1282-1284)ACC>ACA	p.T428T	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Silent_p.T402T|GALC_uc010tvy.1_Silent_p.T405T|GALC_uc010tvz.1_Silent_p.T372T	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	428					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						TTCCAAGTTTGGTATACCATA	0.333													T	88416243	T	T	88416243	2	4	196	1	0	0	0	0	0	0	0	1	6201	1335	47	5		5	GALC	14	88416243	Silent	SNP	G	TCGA-27-2526-01A-01D-1494-08		88416243	18933297	43	13915											
CKMT1B	1159	broad.mit.edu	37	chr15	43891425	43891425	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaacggcgtctggagagagGccaggatatccgcatcccca	13	12	1	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr15:43891425G>A	uc001zsc.2	+	10	1600	c.1208G>A	c.(1207-1209)GGC>GAC	p.G403D	CKMT1B_uc010uds.1_Missense_Mutation_p.G434D|CKMT1B_uc001zsd.3_Missense_Mutation_p.G403D|CKMT1B_uc010bdj.2_RNA	NM_020990	NP_066270	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B precursor	403					creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	CTGGAGAGAGGCCAGGATATC	0.493													A	43891425	A	A	43891425	3	1	196	1	0	0	0	0	1	0	0	0	3450	1203	42	3	1242	3	CKMT1B	15	43891425	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08		43891425	58639967	44	13916											
FBN1	2200	broad.mit.edu	37	chr15	48760692	48760692	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggagtgttgacacagttcCcactgatgcacgtggttgga	13	9	0	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr15:48760692C>T	uc001zwx.1	-	37	4827	c.4499G>A	c.(4498-4500)GGG>GAG	p.G1500E	FBN1_uc010beo.1_5'Flank	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1500	EGF-like 26; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GACACAGTTCCCACTGATGCA	0.473													T	48760692	T	T	48760692	3	4	196	1	0	0	0	0	1	0	0	0	5702	623	22	3	4236	3	FBN1	15	48760692	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	4869267	48760692	53770700	45	13917											
IGF1R	3480	broad.mit.edu	37	chr15	99251008	99251008	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacctcttccccaacctcacGgtcatccgcggctggaaact	8	17	3	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr15:99251008G>A	uc002bul.2	+	2	362	c.312G>A	c.(310-312)ACG>ACA	p.T104T	IGF1R_uc010urq.1_Silent_p.T104T|IGF1R_uc010bon.2_Silent_p.T104T	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	104					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CCAACCTCACGGTCATCCGCG	0.547													A	99251008	A	A	99251008	2	1	196	1	0	0	0	0	0	0	0	1	7571	1103	39	2		2	IGF1R	15	99251008	Silent	SNP	G	TCGA-27-2526-01A-01D-1494-08	50490316	99251008	3280384	46	13918											
RLTPR	146206	broad.mit.edu	37	chr16	67681065	67681065	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcctacaacctgtggttcCggtgcctctcctgtgtggac	11	13	1	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr16:67681065C>T	uc002etn.2	+	9	778	c.658C>T	c.(658-660)CGG>TGG	p.R220W	RLTPR_uc010cel.1_Missense_Mutation_p.R220W|RLTPR_uc010vjr.1_Missense_Mutation_p.R220W	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	220										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CCTGTGGTTCCGGTGCCTCTC	0.672													T	67681065	T	T	67681065	3	4	196	1	0	0	0	0	1	0	0	0	13394	643	23	2	692	2	RLTPR	16	67681065	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08		67681065	22673688	47	13919											
C19orf28	126321	broad.mit.edu	37	chr19	3550991	3550991	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggctcccacctgagtgccGtgagctccaccttctcatgg	10	16	1	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr19:3550991G>A	uc002lxz.2	-	2	670	c.500C>T	c.(499-501)ACG>ATG	p.T167M	C19orf28_uc002lxw.2_Missense_Mutation_p.T167M|C19orf28_uc002lxx.2_Missense_Mutation_p.T167M|C19orf28_uc002lxy.2_Missense_Mutation_p.T158M	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	167					transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGAGTGCCGTGAGCTCCAC	0.557													A	3550991	A	A	3550991	3	1	196	1	0	0	0	0	1	0	0	0	1917	1145	40	1	1185	1	C19orf28	19	3550991	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08		3550991	55577992	48	13920											
MUC16	94025	broad.mit.edu	37	chr19	9021119	9021119	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggtgacccatgtcctcccCatactgcaggttggtgatgg	13	11	0	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr19:9021119C>T	uc002mkp.2	-	19	37408	c.37204G>A	c.(37204-37206)GGG>AGG	p.G12402R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12404	Extracellular (Potential).|SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGTCCTCCCCATACTGCAGG	0.547													T	9021119	T	T	9021119	3	4	196	1	0	0	0	0	1	0	0	0	9973	594	21	3	6583	3	MUC16	19	9021119	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08	5470128	9021119	50107864	49	13921											
NWD1	284434	broad.mit.edu	37	chr19	16874718	16874718	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttgccctatcacctgcttcActcgggccgcctggaggagc	12	15	2	0	rs111332125		TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr19:16874718A>G	uc002neu.3	+	9	2635	c.2213A>G	c.(2212-2214)CAC>CGC	p.H738R	NWD1_uc002net.3_Missense_Mutation_p.H603R|NWD1_uc002nev.3_Missense_Mutation_p.H532R			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	738							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CACCTGCTTCACTCGGGCCGC	0.612													G	16874718	G	G	16874718	3	3	196	1	0	0	0	0	1	0	0	0	10781	159	6	4	1826	4	NWD1	19	16874718	Missense_Mutation	SNP	A	TCGA-27-2526-01A-01D-1494-08	7853599	16874718	42254265	50	13922											
SYCP2	10388	broad.mit.edu	37	chr20	58471554	58471554	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaatcattgatgcttcAgacatttttcttttgctagg	7	7	3	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr20:58471554A>G	uc002yaz.2	-	18	1573	c.1434T>C	c.(1432-1434)TCT>TCC	p.S478S		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	478					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TTGATGCTTCAGACATTTTTC	0.313													G	58471554	G	G	58471554	2	3	196	1	0	0	0	0	0	0	0	1	15429	175	7	4		4	SYCP2	20	58471554	Silent	SNP	A	TCGA-27-2526-01A-01D-1494-08		58471554	4553966	51	13923											
SFRS15	57466	broad.mit.edu	37	chr21	33044602	33044602	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggatgagaccgggccgggCgccaagaagaccagtagatg	17	9	0	4			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr21:33044602C>T	uc002ypd.2	-	20	2980	c.2554G>A	c.(2554-2556)GCC>ACC	p.A852T	SFRS15_uc002ype.2_Missense_Mutation_p.A830T|SFRS15_uc010glu.2_Missense_Mutation_p.A837T	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	852						nucleus	nucleotide binding|RNA binding				0						CCGGGCCGGGCGCCAAGAAGA	0.562													T	33044602	T	T	33044602	3	4	196	1	0	0	0	0	1	0	0	0	14171	768	27	1	893	1	SFRS15	21	33044602	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08		33044602	15085293	52	13924											
PITPNB	23760	broad.mit.edu	37	chr22	28310333	28310333	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaacatggcaaaaccacaCggctaaaaagacaaaagaaa	7	9	0	3			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chr22:28310333C>T	uc003adk.2	-	2	99	c.23G>A	c.(22-24)CGT>CAT	p.R8H	PITPNB_uc011akh.1_Missense_Mutation_p.R10H|PITPNB_uc003adl.2_Missense_Mutation_p.R8H	NM_012399	NP_036531	P48739	PIPNB_HUMAN	phosphatidylinositol transfer protein, beta	8					lipid metabolic process|transport	Golgi apparatus	lipid binding			skin(1)	1						CAAAACCACACGGCTAAAAAG	0.318													T	28310333	T	T	28310333	3	4	196	1	0	0	0	0	1	0	0	0	11948	536	19	1	832	1	PITPNB	22	28310333	Missense_Mutation	SNP	C	TCGA-27-2526-01A-01D-1494-08		28310333	22994233	53	13925											
ELK1	2002	broad.mit.edu	37	chrX	47509844	47509844	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtgtagcgtggcggtggcGttggcaatgttggcagctcc	18	8	0	0			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chrX:47509844G>A	uc004dik.3	-	1	160	c.-162C>T	c.(-164--160)AACGC>AATGC		ELK1_uc010nhv.2_Translation_Start_Site|ELK1_uc010nhw.2_Translation_Start_Site|ELK1_uc004dil.3_RNA	NM_001114123	NP_001107595	P19419	ELK1_HUMAN	ELK1 protein						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						TGGCGGTGGCGTTGGCAATGT	0.622													A	47509844	A	A	47509844	1	1	196	1	0	0	0	0	0	0	0	0	5059	1160	40	1		1	ELK1	23	47509844	Translation_Start_Site	SNP	G	TCGA-27-2526-01A-01D-1494-08		47509844	107760716	54	13926											
PNMA3	29944	broad.mit.edu	37	chrX	152226004	152226004	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tacagatgtggcaggtgcccGagggggaaaagaggcggagg	20	6	0	2			TCGA-27-2526-01A-01D-1494-08	TCGA-27-2526-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	bc1abcb7-b4e9-4447-b0c5-0fc09401eec0	2cc9e13d-f78f-40bc-b90e-62b7784293f3	g.chrX:152226004G>A	uc004fhc.2	+	2	928	c.592G>A	c.(592-594)GAG>AAG	p.E198K	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	198					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					gcaggtgcccgagggggaaaa	0													A	152226004	A	A	152226004	3	1	196	1	0	0	0	0	1	0	0	0	12155	1059	37	2	594	2	PNMA3	23	152226004	Missense_Mutation	SNP	G	TCGA-27-2526-01A-01D-1494-08	104716160	152226004	3044556	55	13927											
TAS1R2	80834	broad.mit.edu	37	chr1	19181421	19181421	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcggcgctgggtgtggtacgCagcaaagccgggaagcgcac	17	11	0	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:19181421C>T	uc001bba.1	-	3	544	c.543G>A	c.(541-543)CTG>CTA	p.L181L		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	181	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GTGTGGTACGCAGCAAAGCCG	0.622													T	19181421	T	T	19181421	2	4	197	1	0	0	0	0	0	0	0	1	15560	697	25	3		3	TAS1R2	1	19181421	Silent	SNP	C	TCGA-27-2527-01A-01D-1494-08		19181421	230069200	1	13928											
COL16A1	1307	broad.mit.edu	37	chr1	32126216	32126216	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggggaccgggtcttccctgGggtcccatggcaccaggttc	16	13	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:32126216G>T	uc001btk.1	-	62	4214	c.3849C>A	c.(3847-3849)CCC>CCA	p.P1283P	COL16A1_uc001bti.1_5'UTR|COL16A1_uc001btj.1_Silent_p.P1081P	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	1283	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GTCTTCCCTGGGGTCCCATGG	0.547													T	32126216	T	T	32126216	2	4	197	1	0	0	0	0	0	0	0	1	3673	1219	43	5		5	COL16A1	1	32126216	Silent	SNP	G	TCGA-27-2527-01A-01D-1494-08	12944795	32126216	217124405	2	13929											
DAB1	1600	broad.mit.edu	37	chr1	57491656	57491656	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagcaatgcatacttacggGgggagaggttatatcagggg	16	5	1	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:57491656G>A	uc001cys.1	-	12	1458	c.784C>T	c.(784-786)CCC>TCC	p.P262S	DAB1_uc001cyt.1_Missense_Mutation_p.P260S|DAB1_uc001cyq.1_Missense_Mutation_p.P260S|DAB1_uc001cyr.1_Missense_Mutation_p.P176S|DAB1_uc009vzw.1_Missense_Mutation_p.P244S|DAB1_uc009vzx.1_Missense_Mutation_p.P262S	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	295				P -> S (in Ref. 6; AAH67447).	cell differentiation|nervous system development					skin(2)|ovary(1)	3						ATACTTACGGGGGGAGAGGTT	0.358													A	57491656	A	A	57491656	3	1	197	1	0	0	0	0	1	0	0	0	4217	1232	43	3	903	3	DAB1	1	57491656	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	25365440	57491656	191758965	3	13930											
HFM1	164045	broad.mit.edu	37	chr1	91846537	91846537	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaatacttctaaattttgCcgcttacaataacattaagg	5	7	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:91846537C>T	uc001doa.3	-	7	905	c.805G>A	c.(805-807)GCA>ACA	p.A269T	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.A269T	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	269							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CTAAATTTTGCCGCTTACAAT	0.209													T	91846537	T	T	91846537	3	4	197	1	0	0	0	0	1	0	0	0	7083	739	26	3	3634	3	HFM1	1	91846537	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	34354881	91846537	157404084	4	13931											
CCDC18	343099	broad.mit.edu	37	chr1	93649564	93649564	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtgaaaattctgattatgCccctaatccttcaaggtctg	7	9	3	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:93649564C>T	uc001dpq.2	+	3	686	c.518C>T	c.(517-519)GCC>GTC	p.A173V		NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	55										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TCTGATTATGCCCCTAATCCT	0.323													T	93649564	T	T	93649564	3	4	197	1	0	0	0	0	1	0	0	0	2794	739	26	3	528	3	CCDC18	1	93649564	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	1803027	93649564	155601057	5	13932											
PHGDH	26227	broad.mit.edu	37	chr1	120285535	120285535	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	accaggctgtgggcttggtcCaaggcactacgcctgtactg	13	12	0	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:120285535C>G	uc001ehz.2	+	11	1542	c.1315C>G	c.(1315-1317)CAA>GAA	p.Q439E	PHGDH_uc009whm.2_Missense_Mutation_p.Q337E|PHGDH_uc001eia.2_Missense_Mutation_p.Q438E|PHGDH_uc009whn.2_Intron|PHGDH_uc001eib.2_Missense_Mutation_p.Q405E|PHGDH_uc001eic.2_RNA	NM_006623	NP_006614	O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	439					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			ovary(1)	1	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	GGGCTTGGTCCAAGGCACTAC	0.657													G	120285535	G	G	120285535	3	3	197	1	0	0	0	0	1	0	0	0	11841	595	21	5	1357	5	PHGDH	1	120285535	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	26635971	120285535	128965086	6	13933											
THBS3	7059	broad.mit.edu	37	chr1	155170717	155170719	+	In_Frame_Del	DEL	CAT	-	-													cttgatcccatccccatcagCatcatcatcacactggtccc							TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:155170717_155170719delCAT	uc001fix.2	-	13	1540_1542	c.1517_1519delATG	c.(1516-1521)GATGCT>GCT	p.D506del	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_In_Frame_Del_p.D497del|THBS3_uc001fiz.2_In_Frame_Del_p.D469del|THBS3_uc001fiy.2_In_Frame_Del_p.D35del|THBS3_uc010pfu.1_In_Frame_Del_p.D386del|THBS3_uc010pfv.1_RNA|THBS3_uc001fja.2_RNA	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	506	TSP type-3 2.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCCCCATCAGCATCATCATCACA	0.542													-	155170719	-	-	155170717	7	5	197	1	0	1	0	1	0	0	0	0	15852	710	25	0	1395	0	THBS3	1	155170717	In_Frame_Del	DEL	CAT	TCGA-27-2527-01A-01D-1494-08	34885182	155170717	94079904	7	13934											
YY1AP1	55249	broad.mit.edu	37	chr1	155629578	155629578	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gcggctccagagcttgccttCcctcctctgttttcacaacg	8	16	2	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:155629578C>G	uc001fln.2	-	11	2285	c.2261G>C	c.(2260-2262)GGA>GCA	p.G754A	YY1AP1_uc001flg.2_Missense_Mutation_p.G493A|YY1AP1_uc010pgg.1_Missense_Mutation_p.G593A|YY1AP1_uc010pgh.1_Missense_Mutation_p.G697A|YY1AP1_uc010pgi.1_Missense_Mutation_p.G846A|YY1AP1_uc001flh.2_Missense_Mutation_p.G826A|YY1AP1_uc009wqt.2_Missense_Mutation_p.G677A|YY1AP1_uc001flk.2_Missense_Mutation_p.G697A|YY1AP1_uc001fll.2_Missense_Mutation_p.G708A|YY1AP1_uc009wqv.2_Missense_Mutation_p.G425A|YY1AP1_uc001flm.2_Missense_Mutation_p.G697A|YY1AP1_uc001fli.2_Missense_Mutation_p.G708A|YY1AP1_uc009wqu.2_Missense_Mutation_p.G541A|YY1AP1_uc001flj.2_Missense_Mutation_p.G688A|YY1AP1_uc009wqw.2_Missense_Mutation_p.G677A|YY1AP1_uc001flo.2_Missense_Mutation_p.G642A|YY1AP1_uc001flp.2_Missense_Mutation_p.G708A	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	754					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					AGCTTGCCTTCCCTCCTCTGT	0.527													G	155629578	G	G	155629578	3	3	197	1	0	0	0	0	1	0	0	0	17505	855	30	5	133	5	YY1AP1	1	155629578	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	458861	155629578	93621043	8	13935											
CFHR3	10878	broad.mit.edu	37	chr1	196749091	196749091	+	Missense_Mutation	SNP	T	C	C													gctggtctcctactcccagaTgcatccgtgtcagtaagtac							TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:196749091T>C	uc001gtl.2	+	3	505	c.418T>C	c.(418-420)TGC>CGC	p.C140R	CFHR3_uc001gtk.2_Missense_Mutation_p.C140R|CFHR3_uc010poy.1_Missense_Mutation_p.C140R|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	140	Sushi 2.					extracellular space					0						TACTCCCAGATGCATCCGTGT	0.493													C	196749091	C	C	196749091	3	2	197	1	0	0	0	0	1	0	0	0	3286	1464	51	4	428	4	CFHR3	1	196749091	Missense_Mutation	SNP	T	TCGA-27-2527-01A-01D-1494-08	41119513	196749091	52501530	9	13936	16	2									
CFHR3	10878	broad.mit.edu	37	chr1	196749101	196749101	+	Missense_Mutation	SNP	T	A	A													tactcccagatgcatccgtgTcagtaagtacaccgctctga							TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:196749101T>A	uc001gtl.2	+	3	515	c.428T>A	c.(427-429)GTC>GAC	p.V143D	CFHR3_uc001gtk.2_Missense_Mutation_p.V143D|CFHR3_uc010poy.1_Missense_Mutation_p.V143D|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	143				V -> D (in Ref. 1; CAA48639).		extracellular space					0						TGCATCCGTGTCAGTAAGTAC	0.478													A	196749101	A	A	196749101	3	1	197	1	0	0	0	0	1	0	0	0	3286	1667	58	5	438	5	CFHR3	1	196749101	Missense_Mutation	SNP	T	TCGA-27-2527-01A-01D-1494-08	10	196749101	52501520	10	13937	16	2									
OR2G2	81470	broad.mit.edu	37	chr1	247752159	247752159	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggtacagtccaccctcacCctgcagctgcccttctgtgg	9	17	2	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr1:247752159C>T	uc010pyy.1	+	1	498	c.498C>T	c.(496-498)ACC>ACT	p.T166T		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CCACCCTCACCCTGCAGCTGC	0.542													T	247752159	T	T	247752159	2	4	197	1	0	0	0	0	0	0	0	1	10998	610	22	3		3	OR2G2	1	247752159	Silent	SNP	C	TCGA-27-2527-01A-01D-1494-08	51003058	247752159	1498462	11	13938											
NRXN1	9378	broad.mit.edu	37	chr2	50850508	50850508	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcattatcattaaactttcCattcacaggctccactagtg	6	11	2	0	rs34326676		TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr2:50850508C>T	uc010fbq.2	-	6	2654	c.1177G>A	c.(1177-1179)GGA>AGA	p.G393R	NRXN1_uc002rxb.3_Missense_Mutation_p.G40R|NRXN1_uc002rxe.3_Missense_Mutation_p.G360R|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TTAAACTTTCCATTCACAGGC	0.458													T	50850508	T	T	50850508	3	4	197	1	0	0	0	0	1	0	0	0	10665	603	21	3	3801	3	NRXN1	2	50850508	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08		50850508	192348865	12	13939											
PROM2	150696	broad.mit.edu	37	chr2	95947910	95947910	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagtgcaaggaaggggcagCgctctggacagtcctgcagc	16	11	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr2:95947910C>T	uc002suh.1	+	14	1797	c.1664C>T	c.(1663-1665)GCG>GTG	p.A555V	PROM2_uc002sui.2_Missense_Mutation_p.A555V|PROM2_uc002suj.2_Missense_Mutation_p.A209V|PROM2_uc002suk.2_Missense_Mutation_p.A555V|PROM2_uc002sul.2_Missense_Mutation_p.A81V|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	555	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GAAGGGGCAGCGCTCTGGACA	0.627													T	95947910	T	T	95947910	3	4	197	1	0	0	0	0	1	0	0	0	12556	768	27	1	1718	1	PROM2	2	95947910	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	45097402	95947910	147251463	13	13940											
MCM6	4175	broad.mit.edu	37	chr2	136630337	136630337	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caggtccacaaaactcacaaCcaatgtgtttctctcaggac	6	13	3	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr2:136630337C>G	uc002tuw.2	-	2	260	c.184G>C	c.(184-186)GTT>CTT	p.V62L		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	62					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	AAACTCACAACCAATGTGTTT	0.403													G	136630337	G	G	136630337	3	3	197	1	0	0	0	0	1	0	0	0	9391	507	18	5	2345	5	MCM6	2	136630337	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	40682427	136630337	106569036	14	13941											
TTN	7273	broad.mit.edu	37	chr2	179458739	179458739	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagcctgtactgttctccaCaaccacacagtatttgccgg	8	13	1	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr2:179458739C>T	uc010zfg.1	-	246	50901	c.50677G>A	c.(50677-50679)GTG>ATG	p.V16893M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V10588M|TTN_uc010zfi.1_Missense_Mutation_p.V10521M|TTN_uc010zfj.1_Missense_Mutation_p.V10396M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17820							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTTCTCCACAACCACACAG	0.403													T	179458739	T	T	179458739	3	4	197	1	0	0	0	0	1	0	0	0	16732	478	17	3	49862	3	TTN	2	179458739	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	42828402	179458739	63740634	15	13942											
ALS2CR12	130540	broad.mit.edu	37	chr2	202216040	202216040	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actccctgtggagttcttgcGtggtagttgaggggtcttga	15	7	2	2	rs143899839		TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr2:202216040G>A	uc010ftg.2	-	2	532	c.88C>T	c.(88-90)CGC>TGC	p.R30C	ALS2CR12_uc002uya.3_Missense_Mutation_p.R30C|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	30					regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						GAGTTCTTGCGTGGTAGTTGA	0.517													A	202216040	A	A	202216040	3	1	197	1	0	0	0	0	1	0	0	0	553	1145	40	1	1305	1	ALS2CR12	2	202216040	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	22757301	202216040	40983333	16	13943											
THAP4	51078	broad.mit.edu	37	chr2	242573479	242573479	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattggattagacgttttgaGtcctttagggggaacctaca	11	7	0	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr2:242573479G>A	uc002wbt.2	-	2	316	c.93C>T	c.(91-93)GAC>GAT	p.D31D		NM_015963	NP_057047	Q8WY91	THAP4_HUMAN	THAP domain containing 4 isoform 1	31	THAP-type.						DNA binding|metal ion binding				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		GACGTTTTGAGTCCTTTAGGG	0.353													A	242573479	A	A	242573479	2	1	197	1	0	0	0	0	0	0	0	1	15843	1020	36	3		3	THAP4	2	242573479	Silent	SNP	G	TCGA-27-2527-01A-01D-1494-08	40357439	242573479	625894	17	13944											
FANCD2	2177	broad.mit.edu	37	chr3	10108908	10108908	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcagattgtaaatgccttcTgccaggaaacatcacctgag	9	10	2	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:10108908T>C	uc003buw.2	+	26	2479	c.2401T>C	c.(2401-2403)TGC>CGC	p.C801R	FANCD2_uc003bux.1_Missense_Mutation_p.C801R|FANCD2_uc003buy.1_Missense_Mutation_p.C801R|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	801					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AAATGCCTTCTGCCAGGAAAC	0.378			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				C	10108908	C	C	10108908	3	2	197	1	0	0	0	0	1	0	0	0	5665	1580	55	4	2499	4	FANCD2	3	10108908	Missense_Mutation	SNP	T	TCGA-27-2527-01A-01D-1494-08		10108908	187913522	18	13945											
IRAK2	3656	broad.mit.edu	37	chr3	10254939	10254939	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaaacttttgagcttggctGgagacagccttttctggagt	11	7	1	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:10254939G>A	uc003bve.1	+	5	653	c.577G>A	c.(577-579)GGA>AGA	p.G193R		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	193					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						GAGCTTGGCTGGAGACAGCCT	0.493													A	10254939	A	A	10254939	3	1	197	1	0	0	0	0	1	0	0	0	7823	1349	47	3	595	3	IRAK2	3	10254939	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	146031	10254939	187767491	19	13946											
FGD5	152273	broad.mit.edu	37	chr3	14862951	14862951	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagaatatccagattccaccCcggagacctgccagggctgg	12	13	0	3			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:14862951C>A	uc003bzc.2	+	1	2483	c.2373C>A	c.(2371-2373)CCC>CCA	p.P791P	FGD5_uc011avk.1_Silent_p.P791P	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	791					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding	p.A791A(1)		ovary(3)|kidney(1)|pancreas(1)	5						AGATTCCACCCCGGAGACCTG	0.537													A	14862951	A	A	14862951	2	1	197	1	0	0	0	0	0	0	0	1	5836	610	22	5		5	FGD5	3	14862951	Silent	SNP	C	TCGA-27-2527-01A-01D-1494-08	4608012	14862951	183159479	20	13947											
XIRP1	165904	broad.mit.edu	37	chr3	39229284	39229284	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctgggtctcaaaaagccaCcgagctgtgccaacgtcccc	11	15	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:39229284C>T	uc003cjk.1	-	2	1874	c.1653G>A	c.(1651-1653)CGG>CGA	p.R551R	XIRP1_uc003cji.2_Silent_p.R551R|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	551	Interaction with CTNNB1 (By similarity).|Xin 12.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CAAAAAGCCACCGAGCTGTGC	0.632													T	39229284	T	T	39229284	2	4	197	1	0	0	0	0	0	0	0	1	17426	494	18	3		3	XIRP1	3	39229284	Silent	SNP	C	TCGA-27-2527-01A-01D-1494-08	24366333	39229284	158793146	21	13948											
IMPDH2	3615	broad.mit.edu	37	chr3	49062153	49062153	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgttggatgccagcaatcaGgtaagggacaaatttgtgga	14	5	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:49062153G>A	uc003cvt.2	-	12	1470	c.1378C>T	c.(1378-1380)CTG>TTG	p.L460L		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	460					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CCAGCAATCAGGTAAGGGACA	0.552													A	49062153	A	A	49062153	2	1	197	1	0	0	0	0	0	0	0	1	7727	991	35	3		3	IMPDH2	3	49062153	Silent	SNP	G	TCGA-27-2527-01A-01D-1494-08	9832869	49062153	148960277	22	13949											
PBRM1	55193	broad.mit.edu	37	chr3	52595840	52595840	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccattctgtccccaccaggcGgctgagctccccgaaagagt	10	16	1	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:52595840G>A	uc003des.2	-	25	4243	c.4231C>T	c.(4231-4233)CGC>TGC	p.R1411C	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.R1411C|PBRM1_uc003der.2_Missense_Mutation_p.R1379C|PBRM1_uc003det.2_Missense_Mutation_p.R1426C|PBRM1_uc003deu.2_Missense_Mutation_p.R1426C|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.R1411C|PBRM1_uc010hmk.1_Missense_Mutation_p.R1386C|PBRM1_uc003dey.2_Missense_Mutation_p.R1359C|PBRM1_uc003dez.1_Missense_Mutation_p.R1410C	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1411	HMG box.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CCCACCAGGCGGCTGAGCTCC	0.498			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								A	52595840	A	A	52595840	3	1	197	1	0	0	0	0	1	0	0	0	11491	1116	39	2	693	2	PBRM1	3	52595840	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	3533687	52595840	145426590	23	13950											
ATXN7	6314	broad.mit.edu	37	chr3	63981678	63981678	+	Frame_Shift_Del	DEL	C	-	-													ctcttcctcctcctcctcttCttctcattccatggagtctt							TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:63981678delC	uc003dlw.3	+	12	2733	c.2180delC	c.(2179-2181)TCTfs	p.S727fs	ATXN7_uc003dlv.2_Frame_Shift_Del_p.S727fs|ATXN7_uc010hnv.2_Frame_Shift_Del_p.S727fs|ATXN7_uc011bfn.1_Frame_Shift_Del_p.S582fs	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	727	Poly-Ser.|Ser-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		tcctcctcttcttcTCATTCC	0.413													-	63981678	-	-	63981678	7	5	197	1	0	1	0	1	0	0	0	0	1215	913	32	0	2286	0	ATXN7	3	63981678	Frame_Shift_Del	DEL	C	TCGA-27-2527-01A-01D-1494-08	11385838	63981678	134040752	24	13951											
FNDC3B	64778	broad.mit.edu	37	chr3	172065012	172065012	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcctttccagagtcctgataGttctggtgctgacatctcag	10	11	2	3			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:172065012G>C	uc003fhy.2	+	21	2547	c.2375G>C	c.(2374-2376)AGT>ACT	p.S792T	FNDC3B_uc003fhz.3_Missense_Mutation_p.S792T	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	792	Fibronectin type-III 6.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		AGTCCTGATAGTTCTGGTGCT	0.398													C	172065012	C	C	172065012	3	2	197	1	0	0	0	0	1	0	0	0	5970	1029	36	5	2453	5	FNDC3B	3	172065012	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	108083334	172065012	25957418	25	13952											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	10	7	1	2	rs121913279		TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			G	178952085	G	G	178952085	3	3	197	1	0	0	0	0	1	0	0	0	11913	217	8	4	3218	4	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-27-2527-01A-01D-1494-08	6887073	178952085	19070345	26	13953											
IL1RAP	3556	broad.mit.edu	37	chr3	190345166	190345166	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagttttctgatggattctcGcaatgaggtttggtggacca	12	6	2	2	rs138101360		TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr3:190345166G>A	uc003fsm.1	+	8	1036	c.830G>A	c.(829-831)CGC>CAC	p.R277H	IL1RAP_uc003fsk.2_Missense_Mutation_p.R277H|IL1RAP_uc003fsl.2_Missense_Mutation_p.R277H|IL1RAP_uc010hzf.2_Missense_Mutation_p.R136H|IL1RAP_uc010hzg.1_Missense_Mutation_p.R277H|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Missense_Mutation_p.R277H|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Missense_Mutation_p.R277H	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	277	Extracellular (Potential).|Ig-like C2-type 3.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		ATGGATTCTCGCAATGAGGTT	0.348													A	190345166	A	A	190345166	3	1	197	1	0	0	0	0	1	0	0	0	7660	1087	38	1	852	1	IL1RAP	3	190345166	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	11393081	190345166	7677264	27	13954											
UGT2B11	10720	broad.mit.edu	37	chr4	70079956	70079956	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaccgtatgttaagtagcGcagccagcagctcaccacag	9	13	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr4:70079956G>A	uc003heh.2	-	1	494	c.485C>T	c.(484-486)GCG>GTG	p.A162V	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	162					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.A162A(1)		ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						GTTAAGTAGCGCAGCCAGCAG	0.423													A	70079956	A	A	70079956	3	1	197	1	0	0	0	0	1	0	0	0	16954	1087	38	1	1128	1	UGT2B11	4	70079956	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08		70079956	121074320	28	13955											
ADAM29	11086	broad.mit.edu	37	chr4	175897289	175897289	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggattgttgaaattgtagtcGtcattgataattatctgtac	9	4	2	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr4:175897289G>A	uc003iuc.2	+	5	1283	c.613G>A	c.(613-615)GTC>ATC	p.V205I	ADAM29_uc003iud.2_Missense_Mutation_p.V205I|ADAM29_uc010irr.2_Missense_Mutation_p.V205I|ADAM29_uc011cki.1_Missense_Mutation_p.V205I	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	205	Peptidase M12B.|Extracellular (Potential).		V -> I (in a colorectal cancer sample; somatic mutation).		proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding	p.V205I(1)		skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AATTGTAGTCGTCATTGATAA	0.348													A	175897289	A	A	175897289	3	1	197	1	0	0	0	0	1	0	0	0	247	1145	40	1	615	1	ADAM29	4	175897289	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	105817333	175897289	15256987	29	13956											
TMEM174	134288	broad.mit.edu	37	chr5	72469396	72469396	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaaagtgaggaaagggtccCggactcggaacagacaccag	14	9	0	3	rs34059261	byFrequency	TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr5:72469396C>T	uc010izc.2	+	1	374	c.326C>T	c.(325-327)CCG>CTG	p.P109L		NM_153217	NP_694949	Q8WUU8	TM174_HUMAN	transmembrane protein 174	109						integral to membrane				ovary(1)	1		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		GAAAGGGTCCCGGACTCGGAA	0.527													T	72469396	T	T	72469396	3	4	197	1	0	0	0	0	1	0	0	0	16087	652	23	2	328	2	TMEM174	5	72469396	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08		72469396	108445864	30	13957											
EGR1	1958	broad.mit.edu	37	chr5	137803019	137803019	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccctctgtctactattaaggCctttgccactcagtcgggct	8	14	3	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr5:137803019C>A	uc003ldb.1	+	2	1151	c.881C>A	c.(880-882)GCC>GAC	p.A294D	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	294					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACTATTAAGGCCTTTGCCACT	0.627													A	137803019	A	A	137803019	3	1	197	1	0	0	0	0	1	0	0	0	4971	739	26	5	887	5	EGR1	5	137803019	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	65333623	137803019	43112241	31	13958											
DSP	1832	broad.mit.edu	37	chr6	7583937	7583937	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctttttgccaaaagatgtcGccttggcccgggggctgatt	12	10	1	2	rs144539278		TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr6:7583937G>A	uc003mxp.1	+	24	6721	c.6442G>A	c.(6442-6444)GCC>ACC	p.A2148T	DSP_uc003mxq.1_Missense_Mutation_p.A1549T	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2148	Plectin 4.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAAAGATGTCGCCTTGGCCCG	0.478													A	7583937	A	A	7583937	3	1	197	1	0	0	0	0	1	0	0	0	4781	1087	38	1	6536	1	DSP	6	7583937	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08		7583937	163531130	32	13959											
HIST1H2AM	8336	broad.mit.edu	37	chr6	27860752	27860752	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gctccaggatctcggcagttAggtactccagcaccgccgcc	11	16	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr6:27860752A>T	uc003nkb.1	-	1	212	c.176T>A	c.(175-177)CTA>CAA	p.L59Q	HIST1H3J_uc003nka.2_5'Flank|HIST1H2BO_uc003nkc.1_5'Flank	NM_003514	NP_003505	P0C0S8	H2A1_HUMAN	histone cluster 1, H2am	59					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			ovary(2)	2						CTCGGCAGTTAGGTACTCCAG	0.662													T	27860752	T	T	27860752	3	4	197	1	0	0	0	0	1	0	0	0	7139	420	15	5	220	5	HIST1H2AM	6	27860752	Missense_Mutation	SNP	A	TCGA-27-2527-01A-01D-1494-08	20276815	27860752	143254315	33	13960											
NEU1	4758	broad.mit.edu	37	chr6	31830506	31830506	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaagcccagaatccgcggCccccagcgtctgtccgggag	13	16	1	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr6:31830506C>T	uc003nxq.3	-	1	204	c.48G>A	c.(46-48)GGG>GGA	p.G16G	NEU1_uc010jtg.2_RNA|NEU1_uc003nxr.3_RNA|NEU1_uc010jth.2_5'UTR|NEU1_uc003nxs.3_Silent_p.G16G	NM_000434	NP_000425	Q99519	NEUR1_HUMAN	neuraminidase precursor	16						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			ovary(1)	1					Oseltamivir(DB00198)|Zanamivir(DB00558)	GAATCCGCGGCCCCCAGCGTC	0.662													T	31830506	T	T	31830506	2	4	197	1	0	0	0	0	0	0	0	1	10341	726	26	3		3	NEU1	6	31830506	Silent	SNP	C	TCGA-27-2527-01A-01D-1494-08	3969754	31830506	139284561	34	13961											
PKHD1	5314	broad.mit.edu	37	chr6	51751972	51751972	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctgagtgaaggaaagaagCggagcttgtgatgtttggtt	15	3	1	4			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr6:51751972C>T	uc003pah.1	-	44	7344	c.7068G>A	c.(7066-7068)CCG>CCA	p.P2356P	PKHD1_uc010jzn.1_Silent_p.P339P|PKHD1_uc003pai.2_Silent_p.P2356P	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2356	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.P2356P(1)		lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AGGAAAGAAGCGGAGCTTGTG	0.388													T	51751972	T	T	51751972	2	4	197	1	0	0	0	0	0	0	0	1	11971	755	27	1		1	PKHD1	6	51751972	Silent	SNP	C	TCGA-27-2527-01A-01D-1494-08	19921466	51751972	119363095	35	13962											
C6orf165	154313	broad.mit.edu	37	chr6	88170826	88170826	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acacacatactgccaccaacGattgtgagatcatatgagtg	8	10	1	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr6:88170826G>A	uc003plv.2	+	12	1673	c.1581G>A	c.(1579-1581)ACG>ACA	p.T527T	SLC35A1_uc003plx.2_RNA|C6orf165_uc003plw.2_Silent_p.T339T|C6orf165_uc010kbv.1_RNA	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	527										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TGCCACCAACGATTGTGAGAT	0.328													A	88170826	A	A	88170826	2	1	197	1	0	0	0	0	0	0	0	1	2341	1045	37	2		2	C6orf165	6	88170826	Silent	SNP	G	TCGA-27-2527-01A-01D-1494-08	36418854	88170826	82944241	36	13963											
SDK1	221935	broad.mit.edu	37	chr7	4215452	4215452	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagcagctccacatcgacgaTgtgtgaactaacacgtaagt	9	11	0	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr7:4215452T>C	uc003smx.2	+	34	5121	c.4982T>C	c.(4981-4983)ATG>ACG	p.M1661T	SDK1_uc010kso.2_Intron|SDK1_uc003smy.2_Missense_Mutation_p.M148T	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1661	Fibronectin type-III 10.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACATCGACGATGTGTGAACTA	0.582													C	4215452	C	C	4215452	3	2	197	1	0	0	0	0	1	0	0	0	13968	1464	51	4	5116	4	SDK1	7	4215452	Missense_Mutation	SNP	T	TCGA-27-2527-01A-01D-1494-08		4215452	154923211	37	13964											
GPR141	353345	broad.mit.edu	37	chr7	37780665	37780665	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cccaccaggagttctgggctCagctgaaaaacctatttttt	8	11	2	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr7:37780665C>G	uc003tfm.1	+	1	670	c.670C>G	c.(670-672)CAG>GAG	p.Q224E	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	224	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						GTTCTGGGCTCAGCTGAAAAA	0.438													G	37780665	G	G	37780665	3	3	197	1	0	0	0	0	1	0	0	0	6649	827	29	5	672	5	GPR141	7	37780665	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	33565213	37780665	121357998	38	13965											
GLI3	2737	broad.mit.edu	37	chr7	42004153	42004153	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccatcgtctatgatggcatcGaagtcaatctgtaccccttc	7	13	3	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr7:42004153G>A	uc011kbh.1	-	15	4609	c.4518C>T	c.(4516-4518)TTC>TTT	p.F1506F	GLI3_uc011kbg.1_Silent_p.F1447F	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1506	Asp/Glu-rich (acidic).				negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TGATGGCATCGAAGTCAATCT	0.552									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				A	42004153	A	A	42004153	2	1	197	1	0	0	0	0	0	0	0	1	6439	1049	37	2		2	GLI3	7	42004153	Silent	SNP	G	TCGA-27-2527-01A-01D-1494-08	4223488	42004153	117134510	39	13966											
SEMA3E	9723	broad.mit.edu	37	chr7	83095907	83095907	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaaaacccgaacataatttGcacattcaccctaaagcagg	6	12	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr7:83095907G>T	uc003uhy.1	-	4	813	c.347C>A	c.(346-348)GCA>GAA	p.A116E		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	116	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				AACATAATTTGCACATTCACC	0.388													T	83095907	T	T	83095907	3	4	197	1	0	0	0	0	1	0	0	0	14028	1319	46	5	2036	5	SEMA3E	7	83095907	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	41091754	83095907	76042756	40	13967											
SAMD9L	219285	broad.mit.edu	37	chr7	92763418	92763418	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgagtcaccgattttagttTaaggatagtgctgtttacca	9	8	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr7:92763418T>G	uc003umh.1	-	5	3083	c.1867A>C	c.(1867-1869)AAA>CAA	p.K623Q	SAMD9L_uc003umj.1_Missense_Mutation_p.K623Q|SAMD9L_uc003umi.1_Missense_Mutation_p.K623Q|SAMD9L_uc010lfb.1_Missense_Mutation_p.K623Q|SAMD9L_uc003umk.1_Missense_Mutation_p.K623Q|SAMD9L_uc010lfc.1_Missense_Mutation_p.K623Q|SAMD9L_uc010lfd.1_Missense_Mutation_p.K623Q|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	623										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			GATTTTAGTTTAAGGATAGTG	0.383													G	92763418	G	G	92763418	3	3	197	1	0	0	0	0	1	0	0	0	13827	1763	61	5	2891	5	SAMD9L	7	92763418	Missense_Mutation	SNP	T	TCGA-27-2527-01A-01D-1494-08	9667511	92763418	66375245	41	13968											
TRRAP	8295	broad.mit.edu	37	chr7	98581850	98581850	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacaaggactggtcaatgtaGctctggatatattaagtcgg	11	6	2	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr7:98581850G>A	uc003upp.2	+	60	9378	c.9169G>A	c.(9169-9171)GCT>ACT	p.A3057T	TRRAP_uc011kis.1_Missense_Mutation_p.A3028T|TRRAP_uc003upr.2_Missense_Mutation_p.A2745T	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3057	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GGTCAATGTAGCTCTGGATAT	0.448													A	98581850	A	A	98581850	3	1	197	1	0	0	0	0	1	0	0	0	16598	971	34	3	9312	3	TRRAP	7	98581850	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	5818432	98581850	60556813	42	13969											
ZCWPW1	55063	broad.mit.edu	37	chr7	99998699	99998699	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgctgtgctgcagctcccCgctctgccccagctctctcc	9	19	2	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr7:99998699C>T	uc003uut.2	-	18	2133	c.1885G>A	c.(1885-1887)GGG>AGG	p.G629R	ZCWPW1_uc011kjq.1_Missense_Mutation_p.G509R|ZCWPW1_uc003uur.2_3'UTR|ZCWPW1_uc003uus.2_Missense_Mutation_p.G458R|ZCWPW1_uc011kjr.1_3'UTR|ZCWPW1_uc011kjp.1_RNA	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	629							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGCAGCTCCCCGCTCTGCCCC	0.602													T	99998699	T	T	99998699	3	4	197	1	0	0	0	0	1	0	0	0	17594	652	23	2	65	2	ZCWPW1	7	99998699	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	1416849	99998699	59139964	43	13970											
NEFM	4741	broad.mit.edu	37	chr8	24772136	24772136	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaggaaatccgctcccagcTcgaaagccactcagaccaga	9	14	1	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr8:24772136T>C	uc003xed.3	+	1	863	c.830T>C	c.(829-831)CTC>CCC	p.L277P	NEFM_uc011lac.1_Missense_Mutation_p.L277P|NEFM_uc010lue.2_5'Flank|uc010luc.1_5'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	277	Rod.|Coil 2A.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CGCTCCCAGCTCGAAAGCCAC	0.587													C	24772136	C	C	24772136	3	2	197	1	0	0	0	0	1	0	0	0	10316	1551	54	4	832	4	NEFM	8	24772136	Missense_Mutation	SNP	T	TCGA-27-2527-01A-01D-1494-08		24772136	121591886	44	13971											
ANK1	286	broad.mit.edu	37	chr8	41753935	41753935	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggattcctccttctccttctGctcctggagggcctgcgcct	10	16	2	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr8:41753935G>C	uc003xom.2	-	1	346	c.64C>G	c.(64-66)CAG>GAG	p.Q22E		NM_001142446	NP_001135918	P16157	ANK1_HUMAN	ankyrin 1 isoform 9	Error:Variant_position_missing_in_P16157_after_alignment					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TTCTCCTTCTGCTCCTGGAGG	0.637													C	41753935	C	C	41753935	3	2	197	1	0	0	0	0	1	0	0	0	620	1328	46	5	6233	5	ANK1	8	41753935	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	16981799	41753935	104610087	45	13972											
RALYL	138046	broad.mit.edu	37	chr8	85774569	85774569	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgtgtgcctccacctccccGtgcagtaattccgctgaagc	10	16	0	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr8:85774569G>A	uc003ycq.3	+	7	868	c.452G>A	c.(451-453)CGT>CAT	p.R151H	RALYL_uc003ycr.3_Missense_Mutation_p.R151H|RALYL_uc003ycs.3_Missense_Mutation_p.R151H|RALYL_uc010lzy.2_Missense_Mutation_p.R140H|RALYL_uc003yct.3_Missense_Mutation_p.R164H|RALYL_uc003ycu.3_Missense_Mutation_p.R78H|RALYL_uc003ycv.3_Missense_Mutation_p.R63H	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	151							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						CCACCTCCCCGTGCAGTAATT	0.498													A	85774569	A	A	85774569	3	1	197	1	0	0	0	0	1	0	0	0	13020	1145	40	1	513	1	RALYL	8	85774569	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	44020634	85774569	60589453	46	13973											
KCNS2	3788	broad.mit.edu	37	chr8	99440635	99440635	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgagcagagtgaccaggagaGcaccacgtcttccttcgatg	12	12	1	3			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr8:99440635G>A	uc003yin.2	+	2	778	c.428G>A	c.(427-429)AGC>AAC	p.S143N		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	143	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GACCAGGAGAGCACCACGTCT	0.582													A	99440635	A	A	99440635	3	1	197	1	0	0	0	0	1	0	0	0	8089	971	34	3	430	3	KCNS2	8	99440635	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	13666066	99440635	46923387	47	13974											
SNX30	401548	broad.mit.edu	37	chr9	115598647	115598647	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catttgcactcaaactgggaAccattgatcgaatagcccag	8	11	1	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr9:115598647A>T	uc004bgj.3	+	5	920	c.772A>T	c.(772-774)ACC>TCC	p.T258S	SNX30_uc004bgi.3_5'Flank	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	258					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						CAAACTGGGAACCATTGATCG	0.498													T	115598647	T	T	115598647	3	4	197	1	0	0	0	0	1	0	0	0	14900	43	2	5	790	5	SNX30	9	115598647	Missense_Mutation	SNP	A	TCGA-27-2527-01A-01D-1494-08		115598647	25614784	48	13975											
PDCD11	22984	broad.mit.edu	37	chr10	105176336	105176336	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actacctgtcattacctgctAtgccgatgccaagcctggtc	8	14	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr10:105176336A>G	uc001kwy.1	+	13	1694	c.1607A>G	c.(1606-1608)TAT>TGT	p.Y536C		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	536					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ATTACCTGCTATGCCGATGCC	0.493											OREG0020494	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	105176336	G	G	105176336	3	3	197	1	0	0	0	0	1	0	0	0	11617	449	16	4	1653	4	PDCD11	10	105176336	Missense_Mutation	SNP	A	TCGA-27-2527-01A-01D-1494-08		105176336	30358411	49	13976											
KIAA1598	57698	broad.mit.edu	37	chr10	118671332	118671332	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttagttcatccactgcacttTcgcagcctttcgaagattct	6	12	2	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr10:118671332T>G	uc009xyw.2	-	14	1826	c.1328A>C	c.(1327-1329)GAA>GCA	p.E443A	KIAA1598_uc001lcz.3_Missense_Mutation_p.E443A|KIAA1598_uc010qso.1_Missense_Mutation_p.E383A|KIAA1598_uc010qsp.1_Missense_Mutation_p.E443A|KIAA1598_uc010qsq.1_Missense_Mutation_p.E383A|KIAA1598_uc001lcy.3_Missense_Mutation_p.E413A	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	443					axon guidance	axon					0				all cancers(201;0.00494)		CACTGCACTTTCGCAGCCTTT	0.299													G	118671332	G	G	118671332	3	3	197	1	0	0	0	0	1	0	0	0	8246	1783	62	5	583	5	KIAA1598	10	118671332	Missense_Mutation	SNP	T	TCGA-27-2527-01A-01D-1494-08	13494996	118671332	16863415	50	13977											
CPXM2	119587	broad.mit.edu	37	chr10	125506512	125506512	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actctccagggttcaggaggCgccagtaatccccatcgttg	11	13	2	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr10:125506512C>T	uc001lhk.1	-	14	2364	c.2039G>A	c.(2038-2040)CGC>CAC	p.R680H	CPXM2_uc001lhj.2_Intron	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	680					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GTTCAGGAGGCGCCAGTAATC	0.547													T	125506512	T	T	125506512	3	4	197	1	0	0	0	0	1	0	0	0	3838	768	27	1	235	1	CPXM2	10	125506512	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	6835180	125506512	10028235	51	13978											
HPS5	11234	broad.mit.edu	37	chr11	18309168	18309168	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgacaaagttgtatgatatcCgatggcaaaatggatggaaa	11	4	0	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr11:18309168C>T	uc001mod.1	-	18	2909	c.2631G>A	c.(2629-2631)TCG>TCA	p.S877S	HPS5_uc001moe.1_Silent_p.S763S|HPS5_uc001mof.1_Silent_p.S763S	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	877						cytosol				ovary(1)|pancreas(1)|skin(1)	3						GTATGATATCCGATGGCAAAA	0.408									Hermansky-Pudlak_syndrome				T	18309168	T	T	18309168	2	4	197	1	0	0	0	0	0	0	0	1	7342	639	23	2		2	HPS5	11	18309168	Silent	SNP	C	TCGA-27-2527-01A-01D-1494-08		18309168	116697348	52	13979											
SLC5A12	159963	broad.mit.edu	37	chr11	26708091	26708091	+	Frame_Shift_Del	DEL	C	-	-													acatcacgccaaataagagaCctgaaagaaagaaaaattac							TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr11:26708091delC	uc001mra.2	-	10	1467	c.1154delG	c.(1153-1155)TGTfs	p.C385fs	SLC5A12_uc001mrb.2_RNA	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/glucose	385	Cytoplasmic (Potential).				sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2						AAATAAGAGACCTGAAAGAAA	0.453													-	26708091	-	-	26708091	7	5	197	1	0	1	0	1	0	0	0	0	14664	521	18	0	726	0	SLC5A12	11	26708091	Frame_Shift_Del	DEL	C	TCGA-27-2527-01A-01D-1494-08	8398923	26708091	108298425	53	13980											
EXT2	2132	broad.mit.edu	37	chr11	44129545	44129545	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acacgtgttttgatgtctatCgctgtggcttcaacccaaag	9	10	2	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr11:44129545C>T	uc001mxz.2	+	2	617	c.283C>T	c.(283-285)CGC>TGC	p.R95C	EXT2_uc010rfo.1_Missense_Mutation_p.R123C|EXT2_uc001mxy.2_Missense_Mutation_p.R108C|EXT2_uc009ykt.2_Missense_Mutation_p.R95C|EXT2_uc001mya.2_Missense_Mutation_p.R128C	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	95	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						TGATGTCTATCGCTGTGGCTT	0.512			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				T	44129545	T	T	44129545	3	4	197	1	0	0	0	0	1	0	0	0	5324	884	31	2	388	2	EXT2	11	44129545	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	17421454	44129545	90876971	54	13981											
OR4A5	81318	broad.mit.edu	37	chr11	51412077	51412077	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaaggaagacctcagcccCaccaaagaaatggtctataa	8	11	2	3	rs5002407		TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr11:51412077C>T	uc001nhi.1	-	1	319	c.319G>A	c.(319-321)GGG>AGG	p.G107R		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				ACCTCAGCCCCACCAAAGAAA	0.443													T	51412077	T	T	51412077	3	4	197	1	0	0	0	0	1	0	0	0	11043	594	21	3	632	3	OR4A5	11	51412077	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	7282532	51412077	83594439	55	13982											
MMP13	4322	broad.mit.edu	37	chr11	102816396	102816396	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	atttttctcatagacagcatCtactttatcaccaattcctg	3	11	3	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr11:102816396C>A	uc001phl.2	-	9	1322	c.1294G>T	c.(1294-1296)GAT>TAT	p.D432Y		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	432	Hemopexin-like 4.	Calcium 3; via carbonyl oxygen (By similarity).			collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TAGACAGCATCTACTTTATCA	0.328													A	102816396	A	A	102816396	3	1	197	1	0	0	0	0	1	0	0	0	9652	913	32	5	129	5	MMP13	11	102816396	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	51404319	102816396	32190120	56	13983											
MMP13	4322	broad.mit.edu	37	chr11	102826101	102826101	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtgttatcgtcaagtttgCcagtcacctctaagccgaag	10	10	3	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr11:102826101C>T	uc001phl.2	-	2	270	c.242G>A	c.(241-243)GGC>GAC	p.G81D		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	81					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GTCAAGTTTGCCAGTCACCTC	0.473													T	102826101	T	T	102826101	3	4	197	1	0	0	0	0	1	0	0	0	9652	739	26	3	1209	3	MMP13	11	102826101	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	9705	102826101	32180415	57	13984											
OR10G8	219869	broad.mit.edu	37	chr11	123900834	123900834	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttccatttgccctactgtGgacccaactggatccagcac	7	15	0	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr11:123900834G>A	uc001pzp.1	+	1	505	c.505G>A	c.(505-507)GGA>AGA	p.G169R		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GCCCTACTGTGGACCCAACTG	0.537													A	123900834	A	A	123900834	3	1	197	1	0	0	0	0	1	0	0	0	10903	1349	47	3	507	3	OR10G8	11	123900834	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	21074733	123900834	11105682	58	13985											
CACNA1C	775	broad.mit.edu	37	chr12	2716164	2716164	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcaggggcaactacatcaCgtacaaagacggggaggttg	13	9	2	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr12:2716164C>T	uc009zdu.1	+	27	3597	c.3284C>T	c.(3283-3285)ACG>ATG	p.T1095M	CACNA1C_uc009zdv.1_Missense_Mutation_p.T1072M|CACNA1C_uc001qkb.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qkc.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qke.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qkf.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qjz.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qkd.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qkg.2_Missense_Mutation_p.T1075M|CACNA1C_uc009zdw.1_Missense_Mutation_p.T1075M|CACNA1C_uc001qkh.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qkl.2_Missense_Mutation_p.T1095M|CACNA1C_uc001qkn.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qko.2_Missense_Mutation_p.T1095M|CACNA1C_uc001qkp.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qkr.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qku.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qkq.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qks.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qkt.2_Missense_Mutation_p.T1075M|CACNA1C_uc001qka.1_Missense_Mutation_p.T610M|CACNA1C_uc001qki.1_Missense_Mutation_p.T811M|CACNA1C_uc001qkj.1_Missense_Mutation_p.T811M|CACNA1C_uc001qkk.1_Missense_Mutation_p.T811M|CACNA1C_uc001qkm.1_Missense_Mutation_p.T811M	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1095	Extracellular (Potential).|III.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AACTACATCACGTACAAAGAC	0.557													T	2716164	T	T	2716164	3	4	197	1	0	0	0	0	1	0	0	0	2540	536	19	1	3498	1	CACNA1C	12	2716164	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08		2716164	131135731	59	13986											
C1S	716	broad.mit.edu	37	chr12	7174399	7174399	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caaagcaatggaaagtggagTaattccaaactgaaatgtca	9	6	1	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr12:7174399T>A	uc001qsj.2	+	12	1763	c.1044T>A	c.(1042-1044)AGT>AGA	p.S348R	C1S_uc001qsk.2_Missense_Mutation_p.S348R|C1S_uc001qsl.2_Missense_Mutation_p.S348R|C1S_uc009zfr.2_Missense_Mutation_p.S181R|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	348	Sushi 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GAAAGTGGAGTAATTCCAAAC	0.368													A	7174399	A	A	7174399	3	1	197	1	0	0	0	0	1	0	0	0	1974	1635	57	5	1074	5	C1S	12	7174399	Missense_Mutation	SNP	T	TCGA-27-2527-01A-01D-1494-08	4458235	7174399	126677496	60	13987											
SYT10	341359	broad.mit.edu	37	chr12	33538180	33538180	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtcatacgcccagccgtcGgtaggtaacaaagggaaaac	11	10	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr12:33538180G>A	uc001rll.1	-	4	1421	c.1124C>T	c.(1123-1125)CCG>CTG	p.P375L	SYT10_uc009zju.1_Missense_Mutation_p.P185L	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	375	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CCCAGCCGTCGGTAGGTAACA	0.438													A	33538180	A	A	33538180	3	1	197	1	0	0	0	0	1	0	0	0	15463	1116	39	2	463	2	SYT10	12	33538180	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	26363781	33538180	100313715	61	13988											
C12orf68	387856	broad.mit.edu	37	chr12	48578422	48578422	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctccttgggggggacgggCcacttgtggagcccctcgac	16	13	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr12:48578422C>T	uc001rrj.2	+	1	1057	c.517C>T	c.(517-519)CCA>TCA	p.P173S		NM_001013635	NP_001013657	Q52MB2	CL068_HUMAN	hypothetical protein LOC387856	173						cytoplasm				central_nervous_system(1)	1						GGGGGACGGGCCACTTGTGGA	0.607													T	48578422	T	T	48578422	3	4	197	1	0	0	0	0	1	0	0	0	1710	739	26	3	519	3	C12orf68	12	48578422	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	15040242	48578422	85273473	62	13989											
SCN8A	6334	broad.mit.edu	37	chr12	52180608	52180608	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatacctggcccttcttcaaGtagtaagtagtgtttttgtt	9	7	2	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr12:52180608G>A	uc001ryw.2	+	22	4403	c.4225G>A	c.(4225-4227)GTA>ATA	p.V1409I	SCN8A_uc010snl.1_Missense_Mutation_p.V1233I|SCN8A_uc001rza.1_RNA	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1409	III.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CCTTCTTCAAGTAGTAAGTAG	0.403													A	52180608	A	A	52180608	3	1	197	1	0	0	0	0	1	0	0	0	13924	1029	36	3	4307	3	SCN8A	12	52180608	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	3602186	52180608	81671287	63	13990											
KIAA0748	9840	broad.mit.edu	37	chr12	55356553	55356553	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccagagtttgggatggtgCtagcactgtggacatcctct	12	9	1	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr12:55356553C>T	uc001sgn.3	-	9	1239	c.1129G>A	c.(1129-1131)GCA>ACA	p.A377T	KIAA0748_uc001sgl.3_Missense_Mutation_p.A239T|KIAA0748_uc001sgm.3_Missense_Mutation_p.A124T|KIAA0748_uc010spb.1_Missense_Mutation_p.A124T|KIAA0748_uc010spc.1_Missense_Mutation_p.A239T|KIAA0748_uc010spd.1_Missense_Mutation_p.A377T|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	377								p.T377N(1)		ovary(1)|central_nervous_system(1)	2						TGGGATGGTGCTAGCACTGTG	0.527													T	55356553	T	T	55356553	3	4	197	1	0	0	0	0	1	0	0	0	8190	797	28	3	444	3	KIAA0748	12	55356553	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	3175945	55356553	78495342	64	13991											
GPR109A	338442	broad.mit.edu	37	chr12	123187080	123187080	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagccagaagatgcggatccGcacaaccacgctgggaagga	14	11	0	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr12:123187080G>A	uc001ucx.1	-	1	825	c.751C>T	c.(751-753)CGG>TGG	p.R251W	GPR81_uc001ucw.1_Intron	NM_177551	NP_808219	Q8TDS4	HCAR2_HUMAN	G protein-coupled receptor 109A	251	Extracellular (Potential).				negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	ATGCGGATCCGCACAACCACG	0.542													A	123187080	A	A	123187080	3	1	197	1	0	0	0	0	1	0	0	0	6625	1086	38	1	344	1	GPR109A	12	123187080	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08	67830527	123187080	10664815	65	13992											
KLHL1	57626	broad.mit.edu	37	chr13	70535514	70535514	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttgatctcctcttgcttgGcttcacaaacatcacttgta	5	11	4	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr13:70535514G>A	uc001vip.2	-	3	1537	c.743C>T	c.(742-744)GCC>GTC	p.A248V	KLHL1_uc010thm.1_Missense_Mutation_p.A187V	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	248	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTCTTGCTTGGCTTCACAAAC	0.413													A	70535514	A	A	70535514	3	1	197	1	0	0	0	0	1	0	0	0	8365	1203	42	3	1539	3	KLHL1	13	70535514	Missense_Mutation	SNP	G	TCGA-27-2527-01A-01D-1494-08		70535514	44634364	66	13993											
SPTB	6710	broad.mit.edu	37	chr14	65245925	65245925	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgcagattagtgccatagtCggctgactgggccagaggca	14	9	0	3			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr14:65245925C>T	uc001xht.2	-	21	4567	c.4513G>A	c.(4513-4515)GAC>AAC	p.D1505N	SPTB_uc001xhr.2_Missense_Mutation_p.D1505N|SPTB_uc001xhs.2_Missense_Mutation_p.D1505N|SPTB_uc001xhu.2_Missense_Mutation_p.D1505N|SPTB_uc010aqi.2_Missense_Mutation_p.D166N	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1505	Spectrin 12.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GTGCCATAGTCGGCTGACTGG	0.532													T	65245925	T	T	65245925	3	4	197	1	0	0	0	0	1	0	0	0	15117	884	31	2	2602	2	SPTB	14	65245925	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08		65245925	42103615	67	13994											
SPTBN5	51332	broad.mit.edu	37	chr15	42168354	42168354	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcgggtggcgagtagctcGctctcagctgcttcgtgccg	15	13	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr15:42168354G>A	uc001zos.2	-	21	4308	c.3975C>T	c.(3973-3975)AGC>AGT	p.S1325S		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1360	Spectrin 10.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CGAGTAGCTCGCTCTCAGCTG	0.622													A	42168354	A	A	42168354	2	1	197	1	0	0	0	0	0	0	0	1	15121	1078	38	1		1	SPTBN5	15	42168354	Silent	SNP	G	TCGA-27-2527-01A-01D-1494-08		42168354	60363038	68	13995											
HERC1	8925	broad.mit.edu	37	chr15	63948489	63948489	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgctgccaagcacattaatCgaactagcgttcggatatct	8	11	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr15:63948489C>T	uc002amp.2	-	49	9816	c.9668G>A	c.(9667-9669)CGA>CAA	p.R3223Q		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3223					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GCACATTAATCGAACTAGCGT	0.532													T	63948489	T	T	63948489	3	4	197	1	0	0	0	0	1	0	0	0	7057	884	31	2	5037	2	HERC1	15	63948489	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	21780135	63948489	38582903	69	13996											
TMC3	342125	broad.mit.edu	37	chr15	81628948	81628948	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaaagaaacggaaatacttAccttctaccatctgggcaac	6	10	2	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr15:81628948A>G	uc002bgo.1	-	20	2203	c.2203_splice	c.e20+1	p.A735_splice	TMC3_uc010blr.1_Splice_Site	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3							integral to membrane				ovary(1)|liver(1)	2						GGAAATACTTACCTTCTACCA	0.214													G	81628948	G	G	81628948	5	3	197	1	0	0	0	0	0	0	1	0	15983	405	14	4	1109	4	TMC3	15	81628948	Splice_Site	SNP	A	TCGA-27-2527-01A-01D-1494-08	17680459	81628948	20902444	70	13997											
IL34	146433	broad.mit.edu	37	chr16	70693910	70693910	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctcttgcaggtaaacaaagCtccgtcctaaactggcagga	9	11	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr16:70693910C>A	uc002ezh.1	+	6	932	c.549C>A	c.(547-549)AGC>AGA	p.S183R	IL34_uc002ezi.1_Missense_Mutation_p.S182R	NM_152456	NP_689669	Q6ZMJ4	IL34_HUMAN	interleukin 34 precursor	183					positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			central_nervous_system(1)|skin(1)	2						GTAAACAAAGCTCCGTCCTAA	0.562													A	70693910	A	A	70693910	3	1	197	1	0	0	0	0	1	0	0	0	7694	796	28	5	571	5	IL34	16	70693910	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08		70693910	19660843	71	13998											
TTC25	83538	broad.mit.edu	37	chr17	40092757	40092757	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attaagctggagaacaaaggGgacctctccttcttaagcaa	9	9	2	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr17:40092757G>A	uc002hyj.3	+	4	518	c.429G>A	c.(427-429)GGG>GGA	p.G143G	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Silent_p.G143G	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	143						cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				AGAACAAAGGGGACCTCTCCT	0.522													A	40092757	A	A	40092757	2	1	197	1	0	0	0	0	0	0	0	1	16690	1219	43	3		3	TTC25	17	40092757	Silent	SNP	G	TCGA-27-2527-01A-01D-1494-08		40092757	41102453	72	13999											
BZRAP1	9256	broad.mit.edu	37	chr17	56389930	56389930	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tttggcccccgctactgctgCcacccccacctacactcagg	7	20	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr17:56389930C>G	uc002ivx.3	-	17	3123	c.2252G>C	c.(2251-2253)GGC>GCC	p.G751A	BZRAP1_uc010dcs.2_Missense_Mutation_p.G691A|BZRAP1_uc010wnt.1_Missense_Mutation_p.G751A	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	751						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCTACTGCTGCCACCCCCACC	0.632													G	56389930	G	G	56389930	3	3	197	1	0	0	0	0	1	0	0	0	1577	739	26	5	3381	5	BZRAP1	17	56389930	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08	16297173	56389930	24805280	73	14000											
RYR1	6261	broad.mit.edu	37	chr19	38990280	38990280	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catgcgggtggccaggcgagAgcgtggaggagaacgccaat	18	9	0	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr19:38990280A>C	uc002oit.2	+	44	7163	c.7033A>C	c.(7033-7035)AGC>CGC	p.S2345R	RYR1_uc002oiu.2_Missense_Mutation_p.S2345R|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2345	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCCAGGCGAGAGCGTGGAGGA	0.667													C	38990280	C	C	38990280	3	2	197	1	0	0	0	0	1	0	0	0	13768	304	11	5	7207	5	RYR1	19	38990280	Missense_Mutation	SNP	A	TCGA-27-2527-01A-01D-1494-08		38990280	20138703	74	14001											
CADM4	199731	broad.mit.edu	37	chr19	44130439	44130439	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttcctggctgctgctcacTcctgccacaccccggtcaga	8	17	2	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr19:44130439T>C	uc002oxc.1	-	5	550	c.501A>G	c.(499-501)GGA>GGG	p.G167G		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	167	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				TGCTGCTCACTCCTGCCACAC	0.592													C	44130439	C	C	44130439	2	2	197	1	0	0	0	0	0	0	0	1	2569	1565	54	4		4	CADM4	19	44130439	Silent	SNP	T	TCGA-27-2527-01A-01D-1494-08	5140159	44130439	14998544	75	14002											
EML2	24139	broad.mit.edu	37	chr19	46124852	46124852	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcagagcccaaacacgccGccgtcgtgggcgcccagcac	13	18	0	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr19:46124852G>A	uc002pcn.2	-	10	920	c.885C>T	c.(883-885)GGC>GGT	p.G295G	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Silent_p.G179G|EML2_uc010xxl.1_Silent_p.G442G|EML2_uc010xxm.1_Silent_p.G496G|EML2_uc010xxn.1_RNA|EML2_uc010xxo.1_Silent_p.G295G|EML2_uc010ekj.2_Missense_Mutation_p.A262V	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	295	WD 5.				sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		CAAACACGCCGCCGTCGTGGG	0.687													A	46124852	A	A	46124852	2	1	197	1	0	0	0	0	0	0	0	1	5097	1074	38	1		1	EML2	19	46124852	Silent	SNP	G	TCGA-27-2527-01A-01D-1494-08	1994413	46124852	13004131	76	14003											
ZNF324B	388569	broad.mit.edu	37	chr19	58967238	58967238	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccagcgcatccacagcggCgagacgccctacgcgtgccc	11	19	0	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr19:58967238C>T	uc002qsv.1	+	4	1034	c.927C>T	c.(925-927)GGC>GGT	p.G309G	ZNF324B_uc002qsu.1_Silent_p.G299G|ZNF324B_uc010euq.1_Silent_p.G309G	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TCCACAGCGGCGAGACGCCCT	0.687													T	58967238	T	T	58967238	2	4	197	1	0	0	0	0	0	0	0	1	17842	755	27	1		1	ZNF324B	19	58967238	Silent	SNP	C	TCGA-27-2527-01A-01D-1494-08	12842386	58967238	161745	77	14004											
ADAMTS1	9510	broad.mit.edu	37	chr21	28212824	28212824	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggttggcatcgtacgaggtgCcagggagatcgcctgggagc	18	9	0	1			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr21:28212824C>A	uc002ymf.2	-	5	1891	c.1436G>T	c.(1435-1437)GGC>GTC	p.G479V		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	479	Disintegrin.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		GTACGAGGTGCCAGGGAGATC	0.527													A	28212824	A	A	28212824	3	1	197	1	0	0	0	0	1	0	0	0	255	739	26	5	1487	5	ADAMTS1	21	28212824	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08		28212824	19917071	78	14005											
PRAME	23532	broad.mit.edu	37	chr22	22893261	22893261	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggtctccaggtgaagaTgttgtcccttcatcagcact	10	10	3	3			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chr22:22893261T>C	uc002zwf.2	-	3	428	c.272A>G	c.(271-273)CAT>CGT	p.H91R	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Missense_Mutation_p.H75R|PRAME_uc010gtr.2_Missense_Mutation_p.H91R|PRAME_uc002zwg.2_Missense_Mutation_p.H91R|PRAME_uc002zwh.2_Missense_Mutation_p.H91R|PRAME_uc002zwi.2_Missense_Mutation_p.H91R|PRAME_uc002zwj.2_Missense_Mutation_p.H91R|PRAME_uc002zwk.2_Missense_Mutation_p.H91R	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	91					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		CAGGTGAAGATGTTGTCCCTT	0.582													C	22893261	C	C	22893261	3	2	197	1	0	0	0	0	1	0	0	0	12424	1464	51	4	1269	4	PRAME	22	22893261	Missense_Mutation	SNP	T	TCGA-27-2527-01A-01D-1494-08		22893261	28411305	79	14006											
FRMD7	90167	broad.mit.edu	37	chrX	131212279	131212279	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgtctgattggctctgggacCttttaggggtttgctcttga	13	7	3	2			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chrX:131212279C>A	uc004ewn.2	-	12	1944	c.1766G>T	c.(1765-1767)AGG>ATG	p.R589M	FRMD7_uc011muy.1_Missense_Mutation_p.R574M	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	589					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GCTCTGGGACCTTTTAGGGGT	0.433													A	131212279	A	A	131212279	3	1	197	1	0	0	0	0	1	0	0	0	6055	681	24	5	382	5	FRMD7	23	131212279	Missense_Mutation	SNP	C	TCGA-27-2527-01A-01D-1494-08		131212279	24058281	80	14007											
GPR50	9248	broad.mit.edu	37	chrX	150349759	150349759	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtcggcctctagccctgcCgctgggcccaccaagcctgc	12	18	1	0			TCGA-27-2527-01A-01D-1494-08	TCGA-27-2527-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	b8b00995-ada6-493b-bafc-0f6c9def41c9	42ed562f-33ed-4798-a495-42594968feff	g.chrX:150349759C>T	uc010ntg.1	+	2	1839	c.1704C>T	c.(1702-1704)GCC>GCT	p.A568A		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	568	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTAGCCCTGCCGCTGGGCCCA	0.602													T	150349759	T	T	150349759	2	4	197	1	0	0	0	0	0	0	0	1	6697	639	23	2		2	GPR50	23	150349759	Silent	SNP	C	TCGA-27-2527-01A-01D-1494-08	19137480	150349759	4920801	81	14008											
CELA3B	23436	broad.mit.edu	37	chr1	22313121	22313121	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcctttggctgcaacacccGcaggaagcccacggtgttca	11	14	1	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr1:22313121G>A	uc001bfk.2	+	7	855	c.740G>A	c.(739-741)CGC>CAC	p.R247H	CELA3B_uc009vqf.2_Intron	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	247	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						TGCAACACCCGCAGGAAGCCC	0.622													A	22313121	A	A	22313121	3	1	198	1	0	0	0	0	1	0	0	0	3214	1087	38	1	766	1	CELA3B	1	22313121	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08		22313121	226937500	1	14009											
ZNF683	257101	broad.mit.edu	37	chr1	26691223	26691223	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctccagcacctggatttcGggcctgggaaggcagagctt	14	11	0	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr1:26691223G>A	uc001bmg.1	-	4	932	c.814C>T	c.(814-816)CGA>TGA	p.R272*	ZNF683_uc001bmh.1_Nonsense_Mutation_p.R272*|ZNF683_uc009vsj.1_Nonsense_Mutation_p.R272*	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		CCTGGATTTCGGGCCTGGGAA	0.652													A	26691223	A	A	26691223	4	1	198	1	0	0	0	0	0	1	0	0	18087	1124	39	2	712	2	ZNF683	1	26691223	Nonsense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	4378102	26691223	222559398	2	14010											
SPTA1	6708	broad.mit.edu	37	chr1	158614117	158614117	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	actgtctaaggaacttttgtCatctgacctcagggaattct	8	9	5	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr1:158614117C>T	uc001fst.1	-	30	4463	c.4264G>A	c.(4264-4266)GAC>AAC	p.D1422N		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1422	Spectrin 14.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GAACTTTTGTCATCTGACCTC	0.443													T	158614117	T	T	158614117	3	4	198	1	0	0	0	0	1	0	0	0	15115	826	29	3	3087	3	SPTA1	1	158614117	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08	131922894	158614117	90636504	3	14011											
CNTN2	6900	broad.mit.edu	37	chr1	205033757	205033758	+	Frame_Shift_Del	DEL	TG	-	-													tgtccttgccacagagtgacTgtaactccagatggcacctt							TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr1:205033757_205033758delTG	uc001hbr.2	+	12	1667_1668	c.1398_1399delTG	c.(1396-1401)ACTGTAfs	p.T466fs	CNTN2_uc001hbq.1_Frame_Shift_Del_p.T357fs|CNTN2_uc001hbs.2_Frame_Shift_Del_p.T254fs	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	466_467	Ig-like C2-type 5.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACAGAGTGACTGTAACTCCAGA	0.525													-	205033758	-	-	205033757	7	5	198	1	0	1	0	1	0	0	0	0	3641	1567	55	0	1440	0	CNTN2	1	205033757	Frame_Shift_Del	DEL	TG	TCGA-27-2528-01A-01D-1494-08	46419640	205033757	44216864	4	14012											
OBSCN	84033	broad.mit.edu	37	chr1	228468436	228468436	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgacgtgagccctgaagaCgccggcctgtacacctgcca	11	15	0	4			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr1:228468436C>T	uc009xez.1	+	30	8180	c.8136C>T	c.(8134-8136)GAC>GAT	p.D2712D	OBSCN_uc001hsn.2_Silent_p.D2712D|OBSCN_uc001hsp.1_Silent_p.D411D|OBSCN_uc001hsq.1_Translation_Start_Site	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2712	Ig-like 26.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCCCTGAAGACGCCGGCCTGT	0.692													T	228468436	T	T	228468436	2	4	198	1	0	0	0	0	0	0	0	1	10812	535	19	1		1	OBSCN	1	228468436	Silent	SNP	C	TCGA-27-2528-01A-01D-1494-08	23434679	228468436	20782185	5	14013											
SLC4A5	57835	broad.mit.edu	37	chr2	74479508	74479508	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctctgctagggagaacaCagatttcctggaagagaagg	13	8	1	3			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr2:74479508C>T	uc002sko.1	-	11	1278	c.1276G>A	c.(1276-1278)GTG>ATG	p.V426M	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.V426M|SLC4A5_uc010ffc.1_Missense_Mutation_p.V426M|SLC4A5_uc002skp.1_Missense_Mutation_p.V362M|SLC4A5_uc002sks.1_Missense_Mutation_p.V426M	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	426	Cytoplasmic (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						AGGGAGAACACAGATTTCCTG	0.433													T	74479508	T	T	74479508	3	4	198	1	0	0	0	0	1	0	0	0	14657	478	17	3	2201	3	SLC4A5	2	74479508	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08		74479508	168719865	6	14014											
UGGT1	56886	broad.mit.edu	37	chr2	128935427	128935427	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagaagaaggcagatatgGtgaacgaagacttgctgagt	13	5	1	6			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr2:128935427G>A	uc002tps.2	+	33	3824	c.3646G>A	c.(3646-3648)GTG>ATG	p.V1216M	UGGT1_uc002tpr.2_Missense_Mutation_p.V1192M	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1216					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						GGCAGATATGGTGAACGAAGA	0.398													A	128935427	A	A	128935427	3	1	198	1	0	0	0	0	1	0	0	0	16938	1261	44	3	3776	3	UGGT1	2	128935427	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	54455919	128935427	114263946	7	14015											
SP110	3431	broad.mit.edu	37	chr2	231067312	231067312	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	taccctctgatctcgactttCgggcacattcagttctcgcc	7	15	4	1	rs144163010		TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr2:231067312C>T	uc002vqh.3	-	9	1271	c.1031G>A	c.(1030-1032)CGA>CAA	p.R344Q	SP110_uc002vqg.3_Missense_Mutation_p.R344Q|SP110_uc002vqi.3_Missense_Mutation_p.R344Q|SP110_uc010fxk.2_Missense_Mutation_p.R342Q|SP110_uc010fxj.2_Intron	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	344					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TCTCGACTTTCGGGCACATTC	0.478													T	231067312	T	T	231067312	3	4	198	1	0	0	0	0	1	0	0	0	14961	884	31	2	1218	2	SP110	2	231067312	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08	102131885	231067312	12132061	8	14016											
KIF1A	547	broad.mit.edu	37	chr2	241657468	241657468	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccctgcaggcggccctaccGtatggtcccggccaggaggg	16	15	0	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr2:241657468G>A	uc002vzy.2	-	46	5175	c.5029C>T	c.(5029-5031)CGG>TGG	p.R1677W	KIF1A_uc010fzk.2_Missense_Mutation_p.R1778W|KIF1A_uc002vzw.2_Missense_Mutation_p.R338W|KIF1A_uc002vzx.2_Missense_Mutation_p.R404W	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1677					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CGGCCCTACCGTATGGTCCCG	0.662													A	241657468	A	A	241657468	3	1	198	1	0	0	0	0	1	0	0	0	8283	1159	40	1	51	1	KIF1A	2	241657468	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	10590156	241657468	1541905	9	14017											
WDR48	57599	broad.mit.edu	37	chr3	39126186	39126186	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgttttgctgcctgggtttcTgcaaaagatgctggtttcag	12	7	2	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr3:39126186T>G	uc003cit.2	+	13	1342	c.1332T>G	c.(1330-1332)TCT>TCG	p.S444S	WDR48_uc011ayt.1_Silent_p.S435S|WDR48_uc011ayu.1_Silent_p.S362S|WDR48_uc011ayv.1_Silent_p.S169S|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	444					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CCTGGGTTTCTGCAAAAGATG	0.363													G	39126186	G	G	39126186	2	3	198	1	0	0	0	0	0	0	0	1	17298	1567	55	5		5	WDR48	3	39126186	Silent	SNP	T	TCGA-27-2528-01A-01D-1494-08		39126186	158896244	10	14018											
FBXL5	26234	broad.mit.edu	37	chr4	15626935	15626935	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tgagaaacagaagtacacgtCcagtctcttgatcagatttt	8	8	2	4			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr4:15626935C>A	uc003goc.1	-	9	1893	c.1790G>T	c.(1789-1791)GGA>GTA	p.G597V	FBXL5_uc010idw.1_Missense_Mutation_p.G510V|FBXL5_uc003gob.1_Missense_Mutation_p.G471V|FBXL5_uc010idx.1_Missense_Mutation_p.G596V|FBXL5_uc003god.1_Missense_Mutation_p.G580V|FBXL5_uc010idy.1_Missense_Mutation_p.G597V	NM_012161	NP_036293	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5 isoform	597	LRR 5.				iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0						AAGTACACGTCCAGTCTCTTG	0.393													A	15626935	A	A	15626935	3	1	198	1	0	0	0	0	1	0	0	0	5722	855	30	5	297	5	FBXL5	4	15626935	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08		15626935	175527341	11	14019											
NIPAL1	152519	broad.mit.edu	37	chr4	48037778	48037778	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagccagtttacaaacatccGctggtctttgttttgctggc	9	10	1	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr4:48037778G>A	uc003gxw.2	+	6	888	c.822G>A	c.(820-822)CCG>CCA	p.P274P		NM_207330	NP_997213	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	274	Helical; (Potential).					integral to membrane					0						ACAAACATCCGCTGGTCTTTG	0.428													A	48037778	A	A	48037778	2	1	198	1	0	0	0	0	0	0	0	1	10424	1074	38	1		1	NIPAL1	4	48037778	Silent	SNP	G	TCGA-27-2528-01A-01D-1494-08	32410843	48037778	143116498	12	14020											
BMP3	651	broad.mit.edu	37	chr4	81967723	81967723	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtagactttgcagatattgGctggagtgaatggattatct	13	4	1	3			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr4:81967723G>T	uc003hmg.3	+	2	1468	c.1148G>T	c.(1147-1149)GGC>GTC	p.G383V		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	383					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						GCAGATATTGGCTGGAGTGAA	0.478													T	81967723	T	T	81967723	3	4	198	1	0	0	0	0	1	0	0	0	1461	1203	42	5	1154	5	BMP3	4	81967723	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	33929945	81967723	109186553	13	14021											
NDST4	64579	broad.mit.edu	37	chr4	115998108	115998108	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agagtagagaaaataggcagAaatgacaatgctcaccaagc	10	7	1	4			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr4:115998108A>G	uc003ibu.2	-	2	764	c.85T>C	c.(85-87)TCT>CCT	p.S29P	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	29	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AAATAGGCAGAAATGACAATG	0.358													G	115998108	G	G	115998108	3	3	198	1	0	0	0	0	1	0	0	0	10258	246	9	4	2585	4	NDST4	4	115998108	Missense_Mutation	SNP	A	TCGA-27-2528-01A-01D-1494-08	34030385	115998108	75156168	14	14022											
RAI14	26064	broad.mit.edu	37	chr5	34811182	34811182	+	Frame_Shift_Del	DEL	G	-	-													gagatctgtcactttctcctGgatcatggagcagatgtcaa							TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr5:34811182delG	uc003jir.2	+	8	712	c.516delG	c.(514-516)CTGfs	p.L172fs	RAI14_uc010iur.2_Frame_Shift_Del_p.L172fs|RAI14_uc011coj.1_Frame_Shift_Del_p.L172fs|RAI14_uc010ius.1_Frame_Shift_Del_p.L101fs|RAI14_uc003jis.2_Frame_Shift_Del_p.L175fs|RAI14_uc003jit.2_Frame_Shift_Del_p.L172fs|RAI14_uc011cok.1_Frame_Shift_Del_p.L164fs	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	172	ANK 5.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					ACTTTCTCCTGGATCATGGAG	0.418													-	34811182	-	-	34811182	7	5	198	1	0	1	0	1	0	0	0	0	13008	1335	47	0	607	0	RAI14	5	34811182	Frame_Shift_Del	DEL	G	TCGA-27-2528-01A-01D-1494-08		34811182	146104078	15	14023											
UGT3A2	167127	broad.mit.edu	37	chr5	36035914	36035914	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agcagaaacacaaaaacgtcGagcaggtactgctcatgcca	9	11	1	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr5:36035914G>A	uc003jjz.1	-	7	1551	c.1458C>T	c.(1456-1458)CTC>CTT	p.L486L	UGT3A2_uc011cos.1_Silent_p.L452L|UGT3A2_uc011cot.1_Silent_p.L184L	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	486	Helical; (Potential).			L -> F (in Ref. 1; AAQ88782).		integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAAAAACGTCGAGCAGGTACT	0.612													A	36035914	A	A	36035914	2	1	198	1	0	0	0	0	0	0	0	1	16961	1045	37	2		2	UGT3A2	5	36035914	Silent	SNP	G	TCGA-27-2528-01A-01D-1494-08	1224732	36035914	144879346	16	14024											
SLCO6A1	133482	broad.mit.edu	37	chr5	101816115	101816115	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgaaaatcgccaatgctgaCatctataagaccaaacacca	5	12	1	3	rs111320089	byFrequency	TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr5:101816115C>T	uc003knn.2	-	2	554	c.382G>A	c.(382-384)GTC>ATC	p.V128I	SLCO6A1_uc003kno.2_Missense_Mutation_p.V128I|SLCO6A1_uc003knp.2_Missense_Mutation_p.V128I|SLCO6A1_uc003knq.2_Missense_Mutation_p.V128I	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	128	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CCAATGCTGACATCTATAAGA	0.328													T	101816115	T	T	101816115	3	4	198	1	0	0	0	0	1	0	0	0	14732	478	17	3	1825	3	SLCO6A1	5	101816115	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08	65780201	101816115	79099145	17	14025											
PCDHB5	26167	broad.mit.edu	37	chr5	140516912	140516912	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaggctgctgagcgagcgCgacgcggccaagcacaggct	16	14	0	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr5:140516912C>T	uc003liq.2	+	1	2113	c.1896C>T	c.(1894-1896)CGC>CGT	p.R632R		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	632	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAGCGAGCGCGACGCGGCCA	0.692													T	140516912	T	T	140516912	2	4	198	1	0	0	0	0	0	0	0	1	11545	755	27	1		1	PCDHB5	5	140516912	Silent	SNP	C	TCGA-27-2528-01A-01D-1494-08	38700797	140516912	40398348	18	14026											
ABLIM3	22885	broad.mit.edu	37	chr5	148586637	148586637	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggctctggacaagcagtggcAcgtcagctgcttcaagtgcc	13	12	3	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr5:148586637A>G	uc003lpy.2	+	6	766	c.515A>G	c.(514-516)CAC>CGC	p.H172R	ABLIM3_uc003lpz.1_Missense_Mutation_p.H172R|ABLIM3_uc003lqa.1_Missense_Mutation_p.H180R|ABLIM3_uc003lqb.2_Missense_Mutation_p.H172R|ABLIM3_uc003lqc.1_Missense_Mutation_p.H172R|ABLIM3_uc003lqd.1_Missense_Mutation_p.H172R|ABLIM3_uc003lqf.2_Missense_Mutation_p.H172R|ABLIM3_uc003lqe.1_Missense_Mutation_p.H172R	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	172	LIM zinc-binding 3.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGCAGTGGCACGTCAGCTGC	0.612													G	148586637	G	G	148586637	3	3	198	1	0	0	0	0	1	0	0	0	96	159	6	4	533	4	ABLIM3	5	148586637	Missense_Mutation	SNP	A	TCGA-27-2528-01A-01D-1494-08	8069725	148586637	32328623	19	14027											
GABRA1	2554	broad.mit.edu	37	chr5	161300296	161300296	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cacaacatgaccatgcccaaCaaactcctgcggatcacaga	6	15	1	2			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr5:161300296C>A	uc010jiw.2	+	6	897	c.429C>A	c.(427-429)AAC>AAA	p.N143K	GABRA1_uc010jix.2_Missense_Mutation_p.N143K|GABRA1_uc010jiy.2_Missense_Mutation_p.N143K|GABRA1_uc003lyx.3_Missense_Mutation_p.N143K|GABRA1_uc010jiz.2_Missense_Mutation_p.N143K|GABRA1_uc010jja.2_Missense_Mutation_p.N143K|GABRA1_uc010jjb.2_Missense_Mutation_p.N143K	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	143	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CCATGCCCAACAAACTCCTGC	0.473													A	161300296	A	A	161300296	3	1	198	1	0	0	0	0	1	0	0	0	6160	477	17	5	443	5	GABRA1	5	161300296	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08	12713659	161300296	19614964	20	14028											
RARS	5917	broad.mit.edu	37	chr5	167919770	167919770	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcatatccagatttggAaaatcctcctctgctagtga	9	10	1	2			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr5:167919770A>G	uc003lzx.2	+	3	328	c.287A>G	c.(286-288)GAA>GGA	p.E96G	RARS_uc011deo.1_5'UTR	NM_002887	NP_002878	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	96					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		CCAGATTTGGAAAATCCTCCT	0.418													G	167919770	G	G	167919770	3	3	198	1	0	0	0	0	1	0	0	0	13058	246	9	4	297	4	RARS	5	167919770	Missense_Mutation	SNP	A	TCGA-27-2528-01A-01D-1494-08	6619474	167919770	12995490	21	14029											
HIST1H2BE	8344	broad.mit.edu	37	chr6	26184206	26184207	+	In_Frame_Ins	INS	-	ATC	ATC													tctcctctaaagccatggggINSatcatgaattcctttgtcaa							TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr6:26184206_26184207insATC	uc003ngt.2	+	1	183_184	c.183_184insATC	c.(181-186)insATC	p.62_63insI		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	62_63					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						AAGCCATGGGGATCATGAATTC	0.574													ATC	26184207	ATC	ATC	26184206	7	5	198	1	0	1	1	0	0	0	0	0	7144	1161	41	0	185	0	HIST1H2BE	6	26184206	In_Frame_Ins	INS	-	TCGA-27-2528-01A-01D-1494-08		26184206	144930861	22	14030											
SLC35D3	340146	broad.mit.edu	37	chr6	137245675	137245675	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gagagcaggcaagaggtcagGggcagcccccgaggagtccc	17	12	1	2			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr6:137245675G>T	uc003qhe.2	+	2	1257	c.1092G>T	c.(1090-1092)AGG>AGT	p.R364S		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	364					carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		AAGAGGTCAGGGGCAGCCCCC	0.637													T	137245675	T	T	137245675	3	4	198	1	0	0	0	0	1	0	0	0	14583	1223	43	5	1098	5	SLC35D3	6	137245675	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	111061469	137245675	33869392	23	14031											
SYNE1	23345	broad.mit.edu	37	chr6	152751311	152751311	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atattttaattggaacagcaAgtttatcttcaaattcagac	5	6	3	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr6:152751311A>T	uc010kiw.2	-	36	5326	c.4724T>A	c.(4723-4725)CTT>CAT	p.L1575H	SYNE1_uc003qot.3_Missense_Mutation_p.L1582H|SYNE1_uc003qou.3_Missense_Mutation_p.L1575H|SYNE1_uc010kjb.1_Missense_Mutation_p.L1558H|SYNE1_uc003qow.2_Missense_Mutation_p.L870H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1575	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGAACAGCAAGTTTATCTTC	0.303										HNSCC(10;0.0054)			T	152751311	T	T	152751311	3	4	198	1	0	0	0	0	1	0	0	0	15442	72	3	5	22186	5	SYNE1	6	152751311	Missense_Mutation	SNP	A	TCGA-27-2528-01A-01D-1494-08	15505636	152751311	18363756	24	14032											
C7orf26	79034	broad.mit.edu	37	chr7	6630085	6630085	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttcgtgttccaggtgcccaaGgagcgcagcgcgcagcccaa	13	14	0	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr7:6630085G>C	uc003sqo.1	+	1	171	c.171G>C	c.(169-171)AAG>AAC	p.K57N	uc011jwy.1_5'Flank|C7orf26_uc003sqp.1_Missense_Mutation_p.K57N|C7orf26_uc003sqq.1_5'UTR	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	57										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		AGGTGCCCAAGGAGCGCAGCG	0.562													C	6630085	C	C	6630085	3	2	198	1	0	0	0	0	1	0	0	0	2381	991	35	5	173	5	C7orf26	7	6630085	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08		6630085	152508578	25	14033											
DNAH11	8701	broad.mit.edu	37	chr7	21603893	21603893	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacggaattcccacagacaCgcatattaatcgctccatta	6	12	0	2			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr7:21603893C>T	uc003svc.2	+	6	1103	c.1072C>T	c.(1072-1074)CGC>TGC	p.R358C		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	358	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CCCACAGACACGCATATTAAT	0.443									Kartagener_syndrome				T	21603893	T	T	21603893	3	4	198	1	0	0	0	0	1	0	0	0	4599	536	19	1	1094	1	DNAH11	7	21603893	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08	14973808	21603893	137534770	26	14034											
EGFR	1956	broad.mit.edu	37	chr7	55220274	55220274	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcccagcagtgctccgggCgctgccgtggcaagtccccc	14	17	0	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr7:55220274C>T	uc003tqk.2	+	6	910	c.664C>T	c.(664-666)CGC>TGC	p.R222C	EGFR_uc003tqh.2_Missense_Mutation_p.R222C|EGFR_uc003tqi.2_Missense_Mutation_p.R222C|EGFR_uc003tqj.2_Missense_Mutation_p.R222C|EGFR_uc010kzg.1_Missense_Mutation_p.R177C|EGFR_uc011kco.1_Missense_Mutation_p.R169C|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	222	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.R222C(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGCTCCGGGCGCTGCCGTGG	0.597		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55220274	T	T	55220274	3	4	198	1	0	0	0	0	1	0	0	0	4967	768	27	1	686	1	EGFR	7	55220274	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08	33616381	55220274	103918389	27	14035											
SPAM1	6677	broad.mit.edu	37	chr7	123593667	123593667	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatctttttcagaagctttGttaaatcaagtggagtatcc	7	7	3	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr7:123593667G>A	uc003vld.2	+	4	445	c.43G>A	c.(43-45)GTT>ATT	p.V15I	SPAM1_uc003vle.2_Missense_Mutation_p.V15I|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.V15I|SPAM1_uc010lku.2_Missense_Mutation_p.V15I	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	15					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	CAGAAGCTTTGTTAAATCAAG	0.373													A	123593667	A	A	123593667	3	1	198	1	0	0	0	0	1	0	0	0	14986	1377	48	3	45	3	SPAM1	7	123593667	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	68373393	123593667	35544996	28	14036											
CUL1	8454	broad.mit.edu	37	chr7	148484161	148484161	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctcgccaagaggctcgtccaCcagaacagtgcaagtgacga	11	13	0	3			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr7:148484161C>G	uc010lpg.2	+	13	1954	c.1428C>G	c.(1426-1428)CAC>CAG	p.H476Q	CUL1_uc003wey.2_Missense_Mutation_p.H476Q|CUL1_uc003wez.2_Missense_Mutation_p.H366Q|CUL1_uc003wfa.2_Missense_Mutation_p.H137Q	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	476					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GGCTCGTCCACCAGAACAGTG	0.448													G	148484161	G	G	148484161	3	3	198	1	0	0	0	0	1	0	0	0	4054	506	18	5	1474	5	CUL1	7	148484161	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08	24890494	148484161	10654502	29	14037											
ENG	2022	broad.mit.edu	37	chr9	130579436	130579436	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagggagctcaccagacaggTcagggctgatgatgttcaag	15	8	3	3			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr9:130579436T>C	uc004bsj.3	-	13	2146	c.1733A>G	c.(1732-1734)GAC>GGC	p.D578G	ENG_uc011mam.1_Missense_Mutation_p.D389G|ENG_uc004bsk.3_Missense_Mutation_p.D578G|uc004bsl.1_RNA	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	578	Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						ACCAGACAGGTCAGGGCTGAT	0.572									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				C	130579436	C	C	130579436	3	2	198	1	0	0	0	0	1	0	0	0	5117	1667	58	4	281	4	ENG	9	130579436	Missense_Mutation	SNP	T	TCGA-27-2528-01A-01D-1494-08		130579436	10633995	30	14038											
CACNA1B	774	broad.mit.edu	37	chr9	141006952	141006952	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggacttgctggtaccaccccAtaagcgtaagtgtgagggtg	14	9	0	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr9:141006952A>G	uc004cog.2	+	39	5676	c.5531A>G	c.(5530-5532)CAT>CGT	p.H1844R	CACNA1B_uc004coi.2_Missense_Mutation_p.H1056R|CACNA1B_uc004cok.1_RNA|CACNA1B_uc010ncp.1_Missense_Mutation_p.H124R	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1844	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GTACCACCCCATAAGCGTAAG	0.577													G	141006952	G	G	141006952	3	3	198	1	0	0	0	0	1	0	0	0	2539	217	8	4	5685	4	CACNA1B	9	141006952	Missense_Mutation	SNP	A	TCGA-27-2528-01A-01D-1494-08	10427516	141006952	206479	31	14039											
JMJD1C	221037	broad.mit.edu	37	chr10	64954062	64954062	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttaccagaaccaggtataatTtgggttggcattaaatgttt	9	5	0	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr10:64954062T>A	uc001jmn.2	-	14	6018	c.5718A>T	c.(5716-5718)CAA>CAT	p.Q1906H	JMJD1C_uc001jml.2_Missense_Mutation_p.Q1687H|JMJD1C_uc001jmm.2_Missense_Mutation_p.Q1618H|JMJD1C_uc010qiq.1_Missense_Mutation_p.Q1724H|JMJD1C_uc009xpi.2_Missense_Mutation_p.Q1724H|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.Q804H	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1906					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CAGGTATAATTTGGGTTGGCA	0.333													A	64954062	A	A	64954062	3	1	198	1	0	0	0	0	1	0	0	0	7950	1838	64	5	1956	5	JMJD1C	10	64954062	Missense_Mutation	SNP	T	TCGA-27-2528-01A-01D-1494-08		64954062	70580685	32	14040											
PDCD11	22984	broad.mit.edu	37	chr10	105204397	105204397	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacagatgtctggtcggtctAtatcgacatgaccatcaagc	9	11	3	2			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr10:105204397A>G	uc001kwy.1	+	35	5489	c.5402A>G	c.(5401-5403)TAT>TGT	p.Y1801C		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1801	HAT 3.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TGGTCGGTCTATATCGACATG	0.597													G	105204397	G	G	105204397	3	3	198	1	0	0	0	0	1	0	0	0	11617	449	16	4	5536	4	PDCD11	10	105204397	Missense_Mutation	SNP	A	TCGA-27-2528-01A-01D-1494-08	40250335	105204397	30330350	33	14041											
CHID1	66005	broad.mit.edu	37	chr11	902312	902312	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccaaagaccttggtgacatCgtagccatggctgttccact	9	13	0	2			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr11:902312C>T	uc001lsl.2	-	4	441	c.280G>A	c.(280-282)GAT>AAT	p.D94N	CHID1_uc010qwu.1_Missense_Mutation_p.D124N|CHID1_uc010qwv.1_Missense_Mutation_p.D155N|CHID1_uc001lsn.2_Missense_Mutation_p.D119N|CHID1_uc001lsm.2_Missense_Mutation_p.D94N|CHID1_uc001lso.2_Missense_Mutation_p.D94N|CHID1_uc001lsp.2_Missense_Mutation_p.D94N|CHID1_uc010qww.1_Missense_Mutation_p.D94N	NM_023947	NP_076436	Q9BWS9	CHID1_HUMAN	chitinase domain containing 1 isoform a	94					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		TTGGTGACATCGTAGCCATGG	0.562													T	902312	T	T	902312	3	4	198	1	0	0	0	0	1	0	0	0	3345	884	31	2	941	2	CHID1	11	902312	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08		902312	134104204	34	14042											
WT1	7490	broad.mit.edu	37	chr11	32413578	32413578	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcggaccgggagaactttcGctgacaagttttacactgga	12	9	0	2	rs121907909		TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr11:32413578G>A	uc001mtn.1	-	9	1568	c.1372C>T	c.(1372-1374)CGA>TGA	p.R458*	WT1_uc001mtl.1_Nonsense_Mutation_p.R246*|WT1_uc001mtm.1_Nonsense_Mutation_p.R229*|WT1_uc001mto.1_Nonsense_Mutation_p.R458*|WT1_uc001mtp.1_Nonsense_Mutation_p.R441*|WT1_uc001mtq.1_Nonsense_Mutation_p.R441*|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	390	C2H2-type 3.				adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.R390*(9)|p.V380_S410del(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GAGAACTTTCGCTGACAAGTT	0.458			D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				A	32413578	A	A	32413578	4	1	198	1	0	0	0	0	0	1	0	0	17405	1095	38	1	189	1	WT1	11	32413578	Nonsense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	31511266	32413578	102592938	35	14043											
OR5W2	390148	broad.mit.edu	37	chr11	55681478	55681478	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgaataacactaactcattgAcctgtgtatctgagcgagag	9	8	2	4			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr11:55681478A>T	uc010rir.1	-	1	581	c.581T>A	c.(580-582)GTC>GAC	p.V194D		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TAACTCATTGACCTGTGTATC	0.393													T	55681478	T	T	55681478	3	4	198	1	0	0	0	0	1	0	0	0	11185	275	10	5	353	5	OR5W2	11	55681478	Missense_Mutation	SNP	A	TCGA-27-2528-01A-01D-1494-08	23267900	55681478	79325038	36	14044											
ATM	472	broad.mit.edu	37	chr11	108143569	108143572	+	Frame_Shift_Del	DEL	TCAA	-	-													ttcgcatgttggctgcagagTcaatcaataggtaatgggtc							TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr11:108143569_108143572delTCAA	uc001pkb.1	+	22	3659_3662	c.3274_3277delTCAA	c.(3274-3279)TCAATCfs	p.S1092fs	ATM_uc009yxr.1_Frame_Shift_Del_p.S1092fs	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1092_1093					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GGCTGCAGAGTCAATCAATAGGTA	0.363			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			-	108143572	-	-	108143569	7	5	198	1	0	1	0	1	0	0	0	0	1109	1667	58	0	3356	0	ATM	11	108143569	Frame_Shift_Del	DEL	TCAA	TCGA-27-2528-01A-01D-1494-08	52462091	108143569	26862947	37	14045											
FOXM1	2305	broad.mit.edu	37	chr12	2975658	2975658	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctcccggacaaacatgtcGtgcagggaaaggttgtggcg	15	9	1	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr12:2975658G>A	uc001qlf.2	-	5	1141	c.876C>T	c.(874-876)CAC>CAT	p.H292H	FOXM1_uc001qle.2_Silent_p.H292H|FOXM1_uc001qlg.2_Silent_p.H292H|FOXM1_uc009zea.2_Silent_p.H291H|FOXM1_uc009zeb.2_Silent_p.H291H	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	292	Fork-head.				cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			CAAACATGTCGTGCAGGGAAA	0.502													A	2975658	A	A	2975658	2	1	198	1	0	0	0	0	0	0	0	1	6018	1136	40	1		1	FOXM1	12	2975658	Silent	SNP	G	TCGA-27-2528-01A-01D-1494-08		2975658	130876237	38	14046											
FAM90A1	55138	broad.mit.edu	37	chr12	8376154	8376154	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctctgcgggtcttgtggcCtgcagaacagaaaaaggtca	12	10	3	2			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr12:8376154C>T	uc001qui.2	-	6	883	c.324_splice	c.e6-1	p.R108_splice	FAM90A1_uc001quh.2_Splice_Site_p.R108_splice	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138								nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		GTCTTGTGGCCTGCAGAACAG	0.542													T	8376154	T	T	8376154	5	4	198	1	0	0	0	0	0	0	1	0	5650	695	24	3	1079	3	FAM90A1	12	8376154	Splice_Site	SNP	C	TCGA-27-2528-01A-01D-1494-08	5400496	8376154	125475741	39	14047											
PTPRO	5800	broad.mit.edu	37	chr12	15650274	15650274	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attatccagaaaaatataacGttttcacaagagtgaacatt	5	6	1	3			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr12:15650274G>A	uc001rcv.1	+	3	619	c.445G>A	c.(445-447)GTT>ATT	p.V149I	PTPRO_uc001rcw.1_Missense_Mutation_p.V149I|PTPRO_uc001rcu.1_Missense_Mutation_p.V149I	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	149	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				AAAATATAACGTTTTCACAAG	0.378													A	15650274	A	A	15650274	3	1	198	1	0	0	0	0	1	0	0	0	12809	1145	40	1	455	1	PTPRO	12	15650274	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	7274120	15650274	118201621	40	14048											
ANP32D	23519	broad.mit.edu	37	chr12	48866783	48866783	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atagagcccctgaaaaagttAgaaaacctcgagagcttaga	9	8	0	5			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr12:48866783A>C	uc010slt.1	+	1	336	c.336A>C	c.(334-336)TTA>TTC	p.L112F		NM_012404	NP_036536	O95626	AN32D_HUMAN	acidic nuclear phosphoprotein 32D	112								p.L112_E113>*(1)		ovary(1)|central_nervous_system(1)	2						TGAAAAAGTTAGAAAACCTCG	0.408													C	48866783	C	C	48866783	3	2	198	1	0	0	0	0	1	0	0	0	708	417	15	5	338	5	ANP32D	12	48866783	Missense_Mutation	SNP	A	TCGA-27-2528-01A-01D-1494-08	33216509	48866783	84985112	41	14049											
NR4A1	3164	broad.mit.edu	37	chr12	52451031	52451031	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggagctcttcatcctccGcctggcgtacaggtgagagc	12	14	2	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr12:52451031G>A	uc001rzs.2	+	6	1663	c.1349G>A	c.(1348-1350)CGC>CAC	p.R450H	NR4A1_uc010sno.1_Missense_Mutation_p.R463H|NR4A1_uc001rzt.2_Missense_Mutation_p.R450H|NR4A1_uc009zmc.2_Missense_Mutation_p.A64T	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	450	Ligand-binding (Potential).				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		TTCATCCTCCGCCTGGCGTAC	0.612													A	52451031	A	A	52451031	3	1	198	1	0	0	0	0	1	0	0	0	10632	1087	38	1	1363	1	NR4A1	12	52451031	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	3584248	52451031	81400864	42	14050											
EFS	10278	broad.mit.edu	37	chr14	23829158	23829158	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctccagggggctgcggggCaacccgggtcagagggtggg	20	11	2	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr14:23829158C>T	uc001wjo.2	-	4	1137	c.529G>A	c.(529-531)GCC>ACC	p.A177T	EFS_uc001wjp.2_Missense_Mutation_p.A84T|EFS_uc010tnm.1_Missense_Mutation_p.A84T	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	177	Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GGCTGCGGGGCAACCCGGGTC	0.652													T	23829158	T	T	23829158	3	4	198	1	0	0	0	0	1	0	0	0	4959	710	25	3	1168	3	EFS	14	23829158	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08		23829158	83520382	43	14051											
CPPED1	55313	broad.mit.edu	37	chr16	12798557	12798557	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tagtagtcgtcgtcctcgtcGatgctctccaggaacagcgg	12	12	1	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr16:12798557G>A	uc002dca.3	-	3	750	c.639C>T	c.(637-639)ATC>ATT	p.I213I	CPPED1_uc002dcb.3_Intron|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	213							hydrolase activity|metal ion binding				0						CGTCCTCGTCGATGCTCTCCA	0.602													A	12798557	A	A	12798557	2	1	198	1	0	0	0	0	0	0	0	1	3822	1048	37	2		2	CPPED1	16	12798557	Silent	SNP	G	TCGA-27-2528-01A-01D-1494-08		12798557	77556196	44	14052											
EFNB3	1949	broad.mit.edu	37	chr17	7612770	7612770	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggatagctctgcggggtgGcggggctgcagatcccccct	17	12	1	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr17:7612770G>A	uc002gis.2	+	5	1296	c.899G>A	c.(898-900)GGC>GAC	p.G300D		NM_001406	NP_001397	Q15768	EFNB3_HUMAN	ephrin-B3 precursor	300	Cytoplasmic (Potential).				cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			ovary(1)	1		all_cancers(10;1.14e-06)|Prostate(122;0.081)				CTGCGGGGTGGCGGGGCTGCA	0.667													A	7612770	A	A	7612770	3	1	198	1	0	0	0	0	1	0	0	0	4957	1203	42	3	917	3	EFNB3	17	7612770	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08		7612770	73582440	45	14053											
DNAH2	146754	broad.mit.edu	37	chr17	7626952	7626952	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttattcttcctagagccacGgttggagggacctcaagcac	10	11	2	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr17:7626952G>A	uc002giu.1	+	2	187	c.173G>A	c.(172-174)CGG>CAG	p.R58Q	DNAH2_uc002git.2_Missense_Mutation_p.R58Q|DNAH2_uc010vuk.1_Missense_Mutation_p.R58Q	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	58	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTAGAGCCACGGTTGGAGGGA	0.393													A	7626952	A	A	7626952	3	1	198	1	0	0	0	0	1	0	0	0	4602	1116	39	2	179	2	DNAH2	17	7626952	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	14182	7626952	73568258	46	14054											
ULK2	9706	broad.mit.edu	37	chr17	19705231	19705231	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttggaccttcgtaccactgCagatctgaaaagtaaattat	8	8	1	2			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr17:19705231C>T	uc002gwm.3	-	16	1809	c.1300G>A	c.(1300-1302)GCA>ACA	p.A434T	ULK2_uc002gwn.2_Missense_Mutation_p.A434T	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	434					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					CGTACCACTGCAGATCTGAAA	0.468													T	19705231	T	T	19705231	3	4	198	1	0	0	0	0	1	0	0	0	16973	710	25	3	1858	3	ULK2	17	19705231	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08	12078279	19705231	61489979	47	14055											
UNC45B	146862	broad.mit.edu	37	chr17	33482349	33482349	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcatgcagtgcggatagaccGaatctgtagcctcatggccg	13	11	2	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr17:33482349G>A	uc002hja.2	+	7	771	c.674G>A	c.(673-675)CGA>CAA	p.R225Q	UNC45B_uc002hjb.2_Missense_Mutation_p.R225Q|UNC45B_uc002hjc.2_Missense_Mutation_p.R225Q|UNC45B_uc010cto.2_Missense_Mutation_p.R225Q	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	225	ARM 2.				cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				CGGATAGACCGAATCTGTAGC	0.562													A	33482349	A	A	33482349	3	1	198	1	0	0	0	0	1	0	0	0	16986	1058	37	2	696	2	UNC45B	17	33482349	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	13777118	33482349	47712861	48	14056											
RNF43	54894	broad.mit.edu	37	chr17	56439918	56439918	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctcaccggcctgctgtggCgggggcggcaccggatgcgc	18	14	1	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr17:56439918C>T	uc002iwf.2	-	5	2630	c.674G>A	c.(673-675)CGC>CAC	p.R225H	RNF43_uc010wnv.1_Missense_Mutation_p.R184H|RNF43_uc002iwh.3_Missense_Mutation_p.R225H|RNF43_uc002iwg.3_Missense_Mutation_p.R225H|RNF43_uc010dcw.2_Missense_Mutation_p.R98H	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	225	Cytoplasmic (Potential).			R -> H (in Ref. 2; BAH12429).		endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCTGCTGTGGCGGGGGCGGCA	0.597													T	56439918	T	T	56439918	3	4	198	1	0	0	0	0	1	0	0	0	13495	768	27	1	1697	1	RNF43	17	56439918	Missense_Mutation	SNP	C	TCGA-27-2528-01A-01D-1494-08	22957569	56439918	24755292	49	14057											
BPTF	2186	broad.mit.edu	37	chr17	65889572	65889572	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaaatatcaacaattatttTaaattgggtcaagaagggaa	9	3	2	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr17:65889572T>C	uc002jgf.2	+	6	2203	c.2142T>C	c.(2140-2142)TTT>TTC	p.F714F	BPTF_uc002jge.2_Silent_p.F840F|BPTF_uc010wqm.1_Silent_p.F777F	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	840	Interaction with MAZ.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACAATTATTTTAAATTGGGTC	0.373													C	65889572	C	C	65889572	2	2	198	1	0	0	0	0	0	0	0	1	1495	1751	61	4		4	BPTF	17	65889572	Silent	SNP	T	TCGA-27-2528-01A-01D-1494-08	9449654	65889572	15305638	50	14058											
DSC1	1823	broad.mit.edu	37	chr18	28736074	28736074	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctggaataggagcccatcGtctcttgctgcgcttgaggg	14	10	1	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr18:28736074G>A	uc002kwn.2	-	4	665	c.403C>T	c.(403-405)CGA>TGA	p.R135*	DSC1_uc002kwm.2_Nonsense_Mutation_p.R135*	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	135	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GGAGCCCATCGTCTCTTGCTG	0.413													A	28736074	A	A	28736074	4	1	198	1	0	0	0	0	0	1	0	0	4765	1153	40	1	2373	1	DSC1	18	28736074	Nonsense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08		28736074	49341174	51	14059											
ALPK2	115701	broad.mit.edu	37	chr18	56171191	56171191	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccgtcaccaggaggcagccActtgttttctggtacaccca	9	14	2	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr18:56171191A>C	uc002lhj.3	-	11	6433	c.6219T>G	c.(6217-6219)AGT>AGG	p.S2073R		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	2073	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GGAGGCAGCCACTTGTTTTCT	0.522													C	56171191	C	C	56171191	3	2	198	1	0	0	0	0	1	0	0	0	545	156	6	5	305	5	ALPK2	18	56171191	Missense_Mutation	SNP	A	TCGA-27-2528-01A-01D-1494-08	27435117	56171191	21906057	52	14060											
SERPINB10	5273	broad.mit.edu	37	chr18	61585273	61585273	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagaaatcctcaagcccaaCgatgactacttacttaaaac	4	12	2	2	rs61761878	byFrequency	TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr18:61585273C>T	uc010xev.1	+	4	399	c.309C>T	c.(307-309)AAC>AAT	p.N103N	SERPINB10_uc010xew.1_Silent_p.N103N	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	103						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				TCAAGCCCAACGATGACTACT	0.353													T	61585273	T	T	61585273	2	4	198	1	0	0	0	0	0	0	0	1	14097	535	19	1		1	SERPINB10	18	61585273	Silent	SNP	C	TCGA-27-2528-01A-01D-1494-08	5414082	61585273	16491975	53	14061											
C3	718	broad.mit.edu	37	chr19	6681977	6681977	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccaggtagatgatgagggtgTtcctatcggagaaggctttg	15	6	0	4			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr19:6681977T>G	uc002mfm.2	-	35	4387	c.4325A>C	c.(4324-4326)AAC>ACC	p.N1442T	C3_uc002mfl.2_Missense_Mutation_p.N178T	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1442	Properdin-binding.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GATGAGGGTGTTCCTATCGGA	0.532													G	6681977	G	G	6681977	3	3	198	1	0	0	0	0	1	0	0	0	2204	1725	60	5	694	5	C3	19	6681977	Missense_Mutation	SNP	T	TCGA-27-2528-01A-01D-1494-08		6681977	52447006	54	14062											
LILRA2	11027	broad.mit.edu	37	chr19	55086977	55086977	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtgcacacaacctctcctccGagtggtcggcccccagtgac	10	17	1	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr19:55086977G>A	uc002qgg.3	+	5	999	c.910G>A	c.(910-912)GAG>AAG	p.E304K	LILRA2_uc010ern.2_Missense_Mutation_p.E304K|LILRA2_uc002qgf.2_Missense_Mutation_p.E304K|LILRA2_uc010yfe.1_Missense_Mutation_p.E304K|LILRA2_uc010yff.1_Missense_Mutation_p.E292K|LILRA2_uc010ero.2_Missense_Mutation_p.E292K|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	304	Ig-like C2-type 3.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CCTCTCCTCCGAGTGGTCGGC	0.677													A	55086977	A	A	55086977	3	1	198	1	0	0	0	0	1	0	0	0	8785	1059	37	2	928	2	LILRA2	19	55086977	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08	48405000	55086977	4042006	55	14063											
NTSR1	4923	broad.mit.edu	37	chr20	61386135	61386135	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcatggtacgccaggcggcCgagcagggccaagtgtgcac	16	12	1	0			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chr20:61386135C>T	uc002ydf.2	+	2	1184	c.813C>T	c.(811-813)GCC>GCT	p.A271A		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	271	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			GCCAGGCGGCCGAGCAGGGCC	0.632													T	61386135	T	T	61386135	2	4	198	1	0	0	0	0	0	0	0	1	10710	639	23	2		2	NTSR1	20	61386135	Silent	SNP	C	TCGA-27-2528-01A-01D-1494-08		61386135	1639385	56	14064											
CXorf22	170063	broad.mit.edu	37	chrX	35938122	35938122	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactgtgcataatatttgccGctggaaccagaaaatccgat	8	9	0	1			TCGA-27-2528-01A-01D-1494-08	TCGA-27-2528-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	374cbd87-428e-4509-85c1-b7d3302c30a0	ba315999-bdef-4b98-8207-7653987bc717	g.chrX:35938122G>A	uc004ddj.2	+	1	265	c.206G>A	c.(205-207)CGC>CAC	p.R69H	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	69										large_intestine(1)|lung(1)|ovary(1)	3						AATATTTGCCGCTGGAACCAG	0.582													A	35938122	A	A	35938122	3	1	198	1	0	0	0	0	1	0	0	0	4102	1087	38	1	208	1	CXorf22	23	35938122	Missense_Mutation	SNP	G	TCGA-27-2528-01A-01D-1494-08		35938122	119332438	57	14065											
CLCA1	1179	broad.mit.edu	37	chr1	86954794	86954794	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaaagtggtgccatcatccAcacagtcgctttggggccct	10	13	1	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr1:86954794A>G	uc001dlt.2	+	8	1427	c.1298A>G	c.(1297-1299)CAC>CGC	p.H433R	CLCA1_uc001dls.1_Missense_Mutation_p.H372R	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	433	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GCCATCATCCACACAGTCGCT	0.473													G	86954794	G	G	86954794	3	3	199	1	0	0	0	0	1	0	0	0	3457	159	6	4	1328	4	CLCA1	1	86954794	Missense_Mutation	SNP	A	TCGA-28-1747-01C-01D-1494-08		86954794	162295827	1	14066											
DCLRE1B	64858	broad.mit.edu	37	chr1	114454356	114454356	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaagagaaactttctccctGgcctgcggaccttgaaaagc	10	11	1	2			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr1:114454356G>A	uc001eeg.2	+	4	1313	c.1142G>A	c.(1141-1143)TGG>TAG	p.W381*	DCLRE1B_uc001eeh.2_Nonsense_Mutation_p.W255*|DCLRE1B_uc001eei.2_Nonsense_Mutation_p.W255*	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	381					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTTCTCCCTGGCCTGCGGAC	0.483								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					A	114454356	A	A	114454356	4	1	199	1	0	0	0	0	0	1	0	0	4295	1357	47	3	1156	3	DCLRE1B	1	114454356	Nonsense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08	27499562	114454356	134796265	2	14067											
HMCN1	83872	broad.mit.edu	37	chr1	186120829	186120829	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gcagtcaatggctttaccctCaccaatgcagtcttcaaaag	7	12	4	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr1:186120829C>A	uc001grq.1	+	95	15079	c.14850C>A	c.(14848-14850)CTC>CTA	p.L4950L	HMCN1_uc001grs.1_Silent_p.L519L	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4950	Nidogen G2 beta-barrel.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GCTTTACCCTCACCAATGCAG	0.348													A	186120829	A	A	186120829	2	1	199	1	0	0	0	0	0	0	0	1	7220	813	29	5		5	HMCN1	1	186120829	Silent	SNP	C	TCGA-28-1747-01C-01D-1494-08	71666473	186120829	63129792	3	14068											
PLA2G4A	5321	broad.mit.edu	37	chr1	186948519	186948519	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgatgacccagaatcaccatTttcaaccttcaattttcaat	3	11	4	3			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr1:186948519T>G	uc001gsc.2	+	17	2238	c.2033T>G	c.(2032-2034)TTT>TGT	p.F678C	PLA2G4A_uc010pos.1_Missense_Mutation_p.F618C	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	678	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	GAATCACCATTTTCAACCTTC	0.358													G	186948519	G	G	186948519	3	3	199	1	0	0	0	0	1	0	0	0	12001	1841	64	5	2095	5	PLA2G4A	1	186948519	Missense_Mutation	SNP	T	TCGA-28-1747-01C-01D-1494-08	827690	186948519	62302102	4	14069											
NT5C1B	93034	broad.mit.edu	37	chr2	18766137	18766137	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgaccggggcagctggggCgacgcgggtggctggagcga	22	10	0	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr2:18766137C>T	uc002rcz.2	-	5	650	c.546G>A	c.(544-546)TCG>TCA	p.S182S	NT5C1B_uc002rcy.2_Silent_p.S182S|NT5C1B_uc010exr.2_Silent_p.S124S|NT5C1B_uc010yju.1_Silent_p.S122S|NT5C1B_uc002rda.2_Silent_p.S122S|NT5C1B_uc010yjv.1_Silent_p.S199S|NT5C1B_uc010yjw.1_Silent_p.S165S|NT5C1B_uc010exs.2_Silent_p.S184S|NT5C1B_uc002rdb.1_5'UTR	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	182	Pro-rich.				purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GCAGCTGGGGCGACGCGGGTG	0.716													T	18766137	T	T	18766137	2	4	199	1	0	0	0	0	0	0	0	1	10686	755	27	1		1	NT5C1B	2	18766137	Silent	SNP	C	TCGA-28-1747-01C-01D-1494-08		18766137	224433236	5	14070											
IL18R1	8809	broad.mit.edu	37	chr2	102988458	102988459	+	Frame_Shift_Del	DEL	AC	-	-													aatgtcatcagaagaaataaAcacagctgtttcactgaaag							TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr2:102988458_102988459delAC	uc002tbw.3	+	4	498_499	c.348_349delAC	c.(346-351)AAACACfs	p.K116fs	IL18R1_uc010ywb.1_Frame_Shift_Del_p.K116fs|IL18R1_uc010ywc.1_Frame_Shift_Del_p.K116fs|IL18R1_uc010ywd.1_5'UTR|IL18R1_uc010fiy.2_Frame_Shift_Del_p.K116fs	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	116_117	Ig-like C2-type 1.|Extracellular (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						GAAGAAATAAACACAGCTGTTT	0.277													-	102988459	-	-	102988458	7	5	199	1	0	1	0	1	0	0	0	0	7647	40	2	0	358	0	IL18R1	2	102988458	Frame_Shift_Del	DEL	AC	TCGA-28-1747-01C-01D-1494-08	84222321	102988458	140210915	6	14071											
CALCRL	10203	broad.mit.edu	37	chr2	188223966	188223966	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgtaatataagcttctagcaAtggcatgtatacaagcagga	9	6	1	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr2:188223966A>T	uc002upv.3	-	11	1363	c.815T>A	c.(814-816)ATT>AAT	p.I272N	CALCRL_uc010frt.2_Missense_Mutation_p.I272N	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	272	Helical; Name=4; (Potential).					integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			GCTTCTAGCAATGGCATGTAT	0.244													T	188223966	T	T	188223966	3	4	199	1	0	0	0	0	1	0	0	0	2580	101	4	5	590	5	CALCRL	2	188223966	Missense_Mutation	SNP	A	TCGA-28-1747-01C-01D-1494-08	85235508	188223966	54975407	7	14072											
BMPR2	659	broad.mit.edu	37	chr2	203397336	203397336	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatcagatatatggcaccagAagtgctagaaggagctgtga	12	6	1	4			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr2:203397336A>G	uc002uzf.3	+	9	2305	c.1157A>G	c.(1156-1158)GAA>GGA	p.E386G	BMPR2_uc010ftr.2_Missense_Mutation_p.E386G	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	386	Protein kinase.|Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						ATGGCACCAGAAGTGCTAGAA	0.318													G	203397336	G	G	203397336	3	3	199	1	0	0	0	0	1	0	0	0	1471	246	9	4	1191	4	BMPR2	2	203397336	Missense_Mutation	SNP	A	TCGA-28-1747-01C-01D-1494-08	15173370	203397336	39802037	8	14073											
SCG2	7857	broad.mit.edu	37	chr2	224463759	224463759	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggggacagagacaccttggTagggattataatctgggctg	16	6	1	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr2:224463759T>C	uc002vnm.2	-	2	375	c.242A>G	c.(241-243)TAC>TGC	p.Y81C		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	81					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GACACCTTGGTAGGGATTATA	0.448													C	224463759	C	C	224463759	3	2	199	1	0	0	0	0	1	0	0	0	13891	1638	57	4	1615	4	SCG2	2	224463759	Missense_Mutation	SNP	T	TCGA-28-1747-01C-01D-1494-08	21066423	224463759	18735614	9	14074											
OR5K4	403278	broad.mit.edu	37	chr3	98072818	98072818	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctatctggtcaccatggtgGggaatcttggtctggtggca	14	8	5	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr3:98072818G>A	uc011bgv.1	+	1	121	c.121G>A	c.(121-123)GGG>AGG	p.G41R		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						CACCATGGTGGGGAATCTTGG	0.458													A	98072818	A	A	98072818	3	1	199	1	0	0	0	0	1	0	0	0	11169	1232	43	3	123	3	OR5K4	3	98072818	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		98072818	99949612	10	14075											
ADAM29	11086	broad.mit.edu	37	chr4	175897608	175897608	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaatgtgtacaccacaccGtagttgtgcaattgttactt	9	8	0	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr4:175897608G>A	uc003iuc.2	+	5	1602	c.932G>A	c.(931-933)CGT>CAT	p.R311H	ADAM29_uc003iud.2_Missense_Mutation_p.R311H|ADAM29_uc010irr.2_Missense_Mutation_p.R311H|ADAM29_uc011cki.1_Missense_Mutation_p.R311H	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	311	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ACACCACACCGTAGTTGTGCA	0.428													A	175897608	A	A	175897608	3	1	199	1	0	0	0	0	1	0	0	0	247	1145	40	1	934	1	ADAM29	4	175897608	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		175897608	15256668	11	14076											
SLC6A3	6531	broad.mit.edu	37	chr5	1409844	1409844	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatggtacgtacgttggtgaCgcagaacagggacaggagga	17	6	0	2	rs140401978		TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr5:1409844C>T	uc003jck.2	-	10	1511	c.1390G>A	c.(1390-1392)GTC>ATC	p.V464I		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	464	Helical; Name=9; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	ACGTTGGTGACGCAGAACAGG	0.612													T	1409844	T	T	1409844	3	4	199	1	0	0	0	0	1	0	0	0	14685	536	19	1	496	1	SLC6A3	5	1409844	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08		1409844	179505416	12	14077											
ZFYVE16	9765	broad.mit.edu	37	chr5	79768699	79768699	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtagacctgagagaatacGtggatatctgctgggtagat	13	6	1	4			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr5:79768699G>A	uc003kgr.3	+	16	4446	c.4144G>A	c.(4144-4146)GTG>ATG	p.V1382M	ZFYVE16_uc003kgq.3_Missense_Mutation_p.V1382M|ZFYVE16_uc003kgs.3_Missense_Mutation_p.V1382M|ZFYVE16_uc003kgt.3_Missense_Mutation_p.V470M|ZFYVE16_uc003kgu.3_Missense_Mutation_p.V134M	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	1382					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		GAGAGAATACGTGGATATCTG	0.368													A	79768699	A	A	79768699	3	1	199	1	0	0	0	0	1	0	0	0	17661	1145	40	1	4198	1	ZFYVE16	5	79768699	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08	78358855	79768699	101146561	13	14078											
ACOT12	134526	broad.mit.edu	37	chr5	80643625	80643625	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtagccactgtctccatccaCgccataatctggccaccaaa	6	16	2	0	rs150238683	byFrequency	TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr5:80643625C>T	uc003khl.3	-	6	676	c.621G>A	c.(619-621)GCG>GCA	p.A207A	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	207	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		TCTCCATCCACGCCATAATCT	0.502													T	80643625	T	T	80643625	2	4	199	1	0	0	0	0	0	0	0	1	150	523	19	1		1	ACOT12	5	80643625	Silent	SNP	C	TCGA-28-1747-01C-01D-1494-08	874926	80643625	100271635	14	14079											
PCSK1	5122	broad.mit.edu	37	chr5	95735874	95735874	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaccaggtgctgcatatctcGccaggtgagatttgggctgg	14	9	1	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr5:95735874G>A	uc003kls.1	-	10	1419	c.1213C>T	c.(1213-1215)CGA>TGA	p.R405*	PCSK1_uc010jbi.1_Nonsense_Mutation_p.R95*	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	405	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGCATATCTCGCCAGGTGAGA	0.478													A	95735874	A	A	95735874	4	1	199	1	0	0	0	0	0	1	0	0	11600	1095	38	1	1068	1	PCSK1	5	95735874	Nonsense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08	15092249	95735874	85179386	15	14080											
PCDHA9	9752	broad.mit.edu	37	chr5	140230084	140230084	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acggccactgtgctggtgtcGctggtggagagcggccaggc	18	11	0	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr5:140230084G>A	uc003lhu.2	+	1	2728	c.2004G>A	c.(2002-2004)TCG>TCA	p.S668S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.S668S	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	668	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding	p.S668L(1)		large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTGGTGTCGCTGGTGGAGA	0.677													A	140230084	A	A	140230084	2	1	199	1	0	0	0	0	0	0	0	1	11531	1074	38	1		1	PCDHA9	5	140230084	Silent	SNP	G	TCGA-28-1747-01C-01D-1494-08	44494210	140230084	40685176	16	14081											
PCDHGA12	26025	broad.mit.edu	37	chr5	140811313	140811313	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gataatgcaggatattctgcGcgagccaaagtcctgatcac	10	10	2	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr5:140811313G>A	uc003lkt.1	+	1	1156	c.987G>A	c.(985-987)GCG>GCA	p.A329A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Silent_p.A329A	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	329	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATATTCTGCGCGAGCCAAAG	0.512													A	140811313	A	A	140811313	2	1	199	1	0	0	0	0	0	0	0	1	11553	1074	38	1		1	PCDHGA12	5	140811313	Silent	SNP	G	TCGA-28-1747-01C-01D-1494-08	581229	140811313	40103947	17	14082											
FAM50B	26240	broad.mit.edu	37	chr6	3850733	3850733	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acttcctggagctgcgctccGccggcgtggagcagctcatg	14	14	1	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr6:3850733G>A	uc003mvu.2	+	2	800	c.688G>A	c.(688-690)GCC>ACC	p.A230T		NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	230						nucleus				pancreas(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				GCTGCGCTCCGCCGGCGTGGA	0.652													A	3850733	A	A	3850733	3	1	199	1	0	0	0	0	1	0	0	0	5578	1087	38	1	690	1	FAM50B	6	3850733	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		3850733	167264334	18	14083											
GPX5	2880	broad.mit.edu	37	chr6	28497327	28497327	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaagcagtatgtgggcaagCacatcctcttcgtcaacgtg	10	11	3	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr6:28497327C>T	uc003nll.2	+	2	189	c.187C>T	c.(187-189)CAC>TAC	p.H63Y	GPX5_uc003nlm.2_Missense_Mutation_p.H63Y|GPX5_uc003nln.2_RNA	NM_001509	NP_001500	O75715	GPX5_HUMAN	glutathione peroxidase 5 isoform 1 precursor	63					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			skin(1)	1					Glutathione(DB00143)	TGTGGGCAAGCACATCCTCTT	0.443													T	28497327	T	T	28497327	3	4	199	1	0	0	0	0	1	0	0	0	6743	710	25	3	193	3	GPX5	6	28497327	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	24646594	28497327	142617740	19	14084											
DNAH11	8701	broad.mit.edu	37	chr7	21658736	21658736	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aggtcaagtttttaataaatGaagccacaactttggcagat	8	6	1	2			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr7:21658736G>A	uc003svc.2	+	24	4319	c.4288G>A	c.(4288-4290)GAA>AAA	p.E1430K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1430	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTTAATAAATGAAGCCACAAC	0.418									Kartagener_syndrome				A	21658736	A	A	21658736	3	1	199	1	0	0	0	0	1	0	0	0	4599	1291	45	3	4382	3	DNAH11	7	21658736	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		21658736	137479927	20	14085											
EGFR	1956	broad.mit.edu	37	chr7	55211079	55211079	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggaaaacctgcagatcatcAgaggaaatatgtactacgaa	9	7	2	2			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr7:55211079A>G	uc003tqk.2	+	3	568	c.322A>G	c.(322-324)AGA>GGA	p.R108G	EGFR_uc003tqh.2_Missense_Mutation_p.R108G|EGFR_uc003tqi.2_Missense_Mutation_p.R108G|EGFR_uc003tqj.2_Missense_Mutation_p.R108G|EGFR_uc010kzg.1_Missense_Mutation_p.R108G|EGFR_uc011kco.1_Missense_Mutation_p.R55G	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	108	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R108K(7)|p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GCAGATCATCAGAGGAAATAT	0.418		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			G	55211079	G	G	55211079	3	3	199	1	0	0	0	0	1	0	0	0	4967	180	7	4	332	4	EGFR	7	55211079	Missense_Mutation	SNP	A	TCGA-28-1747-01C-01D-1494-08	33552343	55211079	103927584	21	14086											
EGFR	1956	broad.mit.edu	37	chr7	55223543	55223543	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtaattatgtggtgacagatCacggctcgtgcgtccgagcc	13	10	1	2			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr7:55223543C>T	uc003tqk.2	+	8	1156	c.910C>T	c.(910-912)CAC>TAC	p.H304Y	EGFR_uc003tqh.2_Missense_Mutation_p.H304Y|EGFR_uc003tqi.2_Missense_Mutation_p.H304Y|EGFR_uc003tqj.2_Missense_Mutation_p.H304Y|EGFR_uc010kzg.1_Missense_Mutation_p.H259Y|EGFR_uc011kco.1_Missense_Mutation_p.H251Y|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	304	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGTGACAGATCACGGCTCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55223543	T	T	55223543	3	4	199	1	0	0	0	0	1	0	0	0	4967	826	29	3	940	3	EGFR	7	55223543	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	12464	55223543	103915120	22	14087											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	199	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08	9500	55233043	103905620	23	14088											
PCLO	27445	broad.mit.edu	37	chr7	82585035	82585035	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctctccttttttgtgactcGggctactgtcactgtcctca	7	13	3	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr7:82585035G>A	uc003uhx.2	-	5	5523	c.5234C>T	c.(5233-5235)CCG>CTG	p.P1745L	PCLO_uc003uhv.2_Missense_Mutation_p.P1745L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1676					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTGTGACTCGGGCTACTGTC	0.488													A	82585035	A	A	82585035	3	1	199	1	0	0	0	0	1	0	0	0	11583	1116	39	2	10295	2	PCLO	7	82585035	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08	27351992	82585035	76553628	24	14089											
DYNC1I1	1780	broad.mit.edu	37	chr7	95442583	95442583	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aacccctatgtctccctcctCgaaatcagtgagcactccca	5	17	2	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr7:95442583C>T	uc003uoc.3	+	4	576	c.299C>T	c.(298-300)TCG>TTG	p.S100L	DYNC1I1_uc003uod.3_Missense_Mutation_p.S83L|DYNC1I1_uc003uob.2_Missense_Mutation_p.S83L|DYNC1I1_uc003uoe.3_Missense_Mutation_p.S100L|DYNC1I1_uc010lfl.2_Missense_Mutation_p.S89L	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	100	Interaction with DCTN1 (By similarity).				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TCTCCCTCCTCGAAATCAGTG	0.468													T	95442583	T	T	95442583	3	4	199	1	0	0	0	0	1	0	0	0	4842	893	31	2	309	2	DYNC1I1	7	95442583	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	12857548	95442583	63696080	25	14090											
OR2A7	401427	broad.mit.edu	37	chr7	143956670	143956670	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catctgaatccttgggccaaCgggaaatcccagtaggagga	12	10	1	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr7:143956670C>T	uc011kuc.1	-	1	52	c.52G>A	c.(52-54)GTT>ATT	p.V18I	OR2A9P_uc003wec.1_Intron|OR2A7_uc003wef.2_3'UTR	NM_001005328	NP_001005328	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					CTTGGGCCAACGGGAAATCCC	0.498													T	143956670	T	T	143956670	3	4	199	1	0	0	0	0	1	0	0	0	10982	536	19	1	883	1	OR2A7	7	143956670	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	48514087	143956670	15181993	26	14091											
MTUS1	57509	broad.mit.edu	37	chr8	17503489	17503489	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cccgaattccttggtgactgCaaagggatggcggaggatgt	15	8	0	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr8:17503489C>A	uc003wxv.2	-	15	4233	c.3759G>T	c.(3757-3759)TTG>TTT	p.L1253F	MTUS1_uc003wxt.2_Missense_Mutation_p.L500F|MTUS1_uc011kyg.1_Missense_Mutation_p.L398F|MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.L1199F|MTUS1_uc003wxs.2_Missense_Mutation_p.L419F	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	1253						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		TTGGTGACTGCAAAGGGATGG	0.537													A	17503489	A	A	17503489	3	1	199	1	0	0	0	0	1	0	0	0	9965	709	25	5	57	5	MTUS1	8	17503489	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08		17503489	128860533	27	14092											
TG	7038	broad.mit.edu	37	chr8	133925395	133925395	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagacgttcccagcggaaacCatccgcttcctccaagggga	10	14	0	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr8:133925395C>T	uc003ytw.2	+	20	4304	c.4263C>T	c.(4261-4263)ACC>ACT	p.T1421T	TG_uc010mdw.2_Silent_p.T180T	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1421					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CAGCGGAAACCATCCGCTTCC	0.562													T	133925395	T	T	133925395	2	4	199	1	0	0	0	0	0	0	0	1	15810	581	21	3		3	TG	8	133925395	Silent	SNP	C	TCGA-28-1747-01C-01D-1494-08	116421906	133925395	12438627	28	14093											
AKNA	80709	broad.mit.edu	37	chr9	117099371	117099371	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgcaggctgtgagcctggCgcaggtcggctgacagcgag	17	13	0	2			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr9:117099371C>T	uc004biq.3	-	21	4418	c.4283G>A	c.(4282-4284)CGC>CAC	p.R1428H	AKNA_uc004bin.3_Missense_Mutation_p.R675H|AKNA_uc004bio.3_Missense_Mutation_p.R888H|AKNA_uc004bip.3_Missense_Mutation_p.R1347H|AKNA_uc004bir.3_Missense_Mutation_p.R1428H|AKNA_uc004bis.3_Missense_Mutation_p.R1428H|AKNA_uc010mve.2_Missense_Mutation_p.R1309H	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						GTGAGCCTGGCGCAGGTCGGC	0.682													T	117099371	T	T	117099371	3	4	199	1	0	0	0	0	1	0	0	0	463	768	27	1	40	1	AKNA	9	117099371	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08		117099371	24114060	29	14094											
ALX4	60529	broad.mit.edu	37	chr11	44297101	44297101	+	Frame_Shift_Del	DEL	C	-	-													gaggtctgagctggcccggtCctggggccccttcaccccag							TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr11:44297101delC	uc001myb.2	-	2	678	c.574delG	c.(574-576)GACfs	p.D192fs		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	192					hair follicle development						0						CTGGCCCGGTCCTGGGGCCCC	0.632													-	44297101	-	-	44297101	7	5	199	1	0	1	0	1	0	0	0	0	558	855	30	0	673	0	ALX4	11	44297101	Frame_Shift_Del	DEL	C	TCGA-28-1747-01C-01D-1494-08		44297101	90709415	30	14095											
NCAM1	4684	broad.mit.edu	37	chr11	113076266	113076266	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagctcatgttcaagaatgCgccaaccccacaggagttcc	9	13	2	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr11:113076266C>T	uc009yyq.1	+	4	708	c.14C>T	c.(13-15)GCG>GTG	p.A5V	NCAM1_uc001pno.2_Missense_Mutation_p.A5V	NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	123	Ig-like C2-type 2.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TTCAAGAATGCGCCAACCCCA	0.522													T	113076266	T	T	113076266	3	4	199	1	0	0	0	0	1	0	0	0	10202	768	27	1	383	1	NCAM1	11	113076266	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	68779165	113076266	21930250	31	14096											
FAM55A	120400	broad.mit.edu	37	chr11	114400948	114400948	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gataagatacctctctattcCgggtggtcatgtaggtcaga	11	8	3	2	rs150857743	byFrequency	TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr11:114400948C>T	uc001ppa.2	-	3	773	c.356G>A	c.(355-357)CGG>CAG	p.R119Q	FAM55A_uc010rxd.1_5'UTR|FAM55A_uc001ppb.1_Missense_Mutation_p.R261Q	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	261						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		CTCTCTATTCCGGGTGGTCAT	0.458													T	114400948	T	T	114400948	3	4	199	1	0	0	0	0	1	0	0	0	5584	652	23	2	877	2	FAM55A	11	114400948	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	1324682	114400948	20605568	32	14097											
CD163L1	283316	broad.mit.edu	37	chr12	7531814	7531814	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attagcacacagaattcccaCggcaccctggacattcacct	6	15	1	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr12:7531814C>T	uc001qsy.2	-	9	2157	c.2131G>A	c.(2131-2133)GTG>ATG	p.V711M	CD163L1_uc010sge.1_Missense_Mutation_p.V721M	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	711	SRCR 7.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						AGAATTCCCACGGCACCCTGG	0.502													T	7531814	T	T	7531814	3	4	199	1	0	0	0	0	1	0	0	0	2968	536	19	1	2274	1	CD163L1	12	7531814	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08		7531814	126320081	33	14098											
PPM1H	57460	broad.mit.edu	37	chr12	63195712	63195712	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccggggcccccacccctcCgcgcagggaggctgcccggg	16	20	0	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr12:63195712C>T	uc001srk.3	-	3	789	c.640G>A	c.(640-642)GGA>AGA	p.G214R		NM_020700	NP_065751	Q9ULR3	PPM1H_HUMAN	protein phosphatase 1H (PP2C domain containing)	214	PP2C-like.						phosphoprotein phosphatase activity			lung(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		CCCACCCCTCCGCGCAGGGAG	0.682													T	63195712	T	T	63195712	3	4	199	1	0	0	0	0	1	0	0	0	12341	661	23	2	936	2	PPM1H	12	63195712	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	55663898	63195712	70656183	34	14099											
ATP11A	23250	broad.mit.edu	37	chr13	113527920	113527920	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cacactactggacttggatcAaccattttgtcatctggggg	10	10	3	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr13:113527920A>T	uc001vsi.3	+	27	3179	c.3091A>T	c.(3091-3093)AAC>TAC	p.N1031Y	ATP11A_uc001vsj.3_Missense_Mutation_p.N1031Y|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	1031	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GACTTGGATCAACCATTTTGT	0.448											OREG0003854	type=REGULATORY REGION|Gene=ATP11A|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	T	113527920	T	T	113527920	3	4	199	1	0	0	0	0	1	0	0	0	1119	130	5	5	3197	5	ATP11A	13	113527920	Missense_Mutation	SNP	A	TCGA-28-1747-01C-01D-1494-08		113527920	1641958	35	14100											
AK7	122481	broad.mit.edu	37	chr14	96953242	96953242	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tattctattttagaataaacGactggaggaagtgaaaagag	10	3	1	3			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr14:96953242G>A	uc001yfn.2	+	17	2026	c.1982G>A	c.(1981-1983)CGA>CAA	p.R661Q		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	661	Potential.|Glu-rich.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TAGAATAAACGACTGGAGGAA	0.393													A	96953242	A	A	96953242	3	1	199	1	0	0	0	0	1	0	0	0	444	1058	37	2	2048	2	AK7	14	96953242	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		96953242	10396298	36	14101											
RYR3	6263	broad.mit.edu	37	chr15	33944995	33944995	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagatcaaatcggagcaacGtggacctggagatcggctgt	14	8	1	2			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr15:33944995G>A	uc001zhi.2	+	32	4289	c.4219G>A	c.(4219-4221)GTG>ATG	p.V1407M	RYR3_uc010bar.2_Missense_Mutation_p.V1407M	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1407	4 X approximate repeats.|B30.2/SPRY 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCGGAGCAACGTGGACCTGGA	0.557													A	33944995	A	A	33944995	3	1	199	1	0	0	0	0	1	0	0	0	13770	1145	40	1	4345	1	RYR3	15	33944995	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		33944995	68586397	37	14102											
ZSCAN29	146050	broad.mit.edu	37	chr15	43658464	43658464	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggctcttcagtctcagcatCgctgcctaccaggccagagt	10	14	3	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr15:43658464C>T	uc001zrk.1	-	3	1213	c.1066G>A	c.(1066-1068)GAT>AAT	p.D356N	ZSCAN29_uc001zrj.1_Missense_Mutation_p.D236N|ZSCAN29_uc010bdf.1_Missense_Mutation_p.D355N|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Intron|ZSCAN29_uc001zrm.2_Missense_Mutation_p.D355N	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	356					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		GTCTCAGCATCGCTGCCTACC	0.572													T	43658464	T	T	43658464	3	4	199	1	0	0	0	0	1	0	0	0	18233	884	31	2	1504	2	ZSCAN29	15	43658464	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	9713469	43658464	58872928	38	14103											
SLC28A2	9153	broad.mit.edu	37	chr15	45555359	45555359	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctttgtcctggttcactcGtttttgaaaaagctcctggg	9	9	2	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr15:45555359G>A	uc001zva.2	+	5	428	c.363G>A	c.(361-363)TCG>TCA	p.S121S		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	121	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		TGGTTCACTCGTTTTTGAAAA	0.458													A	45555359	A	A	45555359	2	1	199	1	0	0	0	0	0	0	0	1	14532	1132	40	1		1	SLC28A2	15	45555359	Silent	SNP	G	TCGA-28-1747-01C-01D-1494-08	1896895	45555359	56976033	39	14104											
GRIN2A	2903	broad.mit.edu	37	chr16	10273879	10273879	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagccatgatcatagatgcGcccccatgaatgcccaagat	8	13	2	4			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr16:10273879G>A	uc002czo.3	-	2	938	c.390C>T	c.(388-390)GGC>GGT	p.G130G	GRIN2A_uc010uym.1_Silent_p.G130G|GRIN2A_uc002czr.3_Silent_p.G130G|GRIN2A_uc010buk.2_Silent_p.G130G	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	130	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCATAGATGCGCCCCCATGAA	0.597													A	10273879	A	A	10273879	2	1	199	1	0	0	0	0	0	0	0	1	6779	1074	38	1		1	GRIN2A	16	10273879	Silent	SNP	G	TCGA-28-1747-01C-01D-1494-08		10273879	80080874	40	14105											
HS3ST3A1	9955	broad.mit.edu	37	chr17	13400088	13400088	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgtgacgaagtaactgggcGtcttctccatggtgatctgc	13	10	3	2			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr17:13400088G>A	uc002gob.1	-	2	1445	c.647C>T	c.(646-648)ACG>ATG	p.T216M		NM_006042	NP_006033	Q9Y663	HS3SA_HUMAN	heparan sulfate D-glucosaminyl	216	Substrate binding.|Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			ovary(1)|central_nervous_system(1)	2		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTAACTGGGCGTCTTCTCCAT	0.622													A	13400088	A	A	13400088	3	1	199	1	0	0	0	0	1	0	0	0	7365	1145	40	1	577	1	HS3ST3A1	17	13400088	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		13400088	67795122	41	14106											
HEXIM1	10614	broad.mit.edu	37	chr17	43226653	43226653	+	Frame_Shift_Del	DEL	C	-	-													gaagagctgaaccctgagcgCcccccaggcgcggaggagcg							TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr17:43226653delC	uc002iig.2	+	1	1970	c.96delC	c.(94-96)CGCfs	p.R32fs		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	32					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						ACCCTGAGCGCCCCCCAGGCG	0.632											OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	43226653	-	-	43226653	7	5	199	1	0	1	0	1	0	0	0	0	7076	726	26	0	98	0	HEXIM1	17	43226653	Frame_Shift_Del	DEL	C	TCGA-28-1747-01C-01D-1494-08	29826565	43226653	37968557	42	14107											
ABCA9	10350	broad.mit.edu	37	chr17	67016638	67016638	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	actgattgttttccttgtttCgtggaaggaagacaaaactt	9	6	0	2			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr17:67016638C>T	uc002jhu.2	-	19	2634	c.2491G>A	c.(2491-2493)GAA>AAA	p.E831K	ABCA9_uc010dez.2_Missense_Mutation_p.E831K	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	831					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TTCCTTGTTTCGTGGAAGGAA	0.413													T	67016638	T	T	67016638	3	4	199	1	0	0	0	0	1	0	0	0	39	893	31	2	2467	2	ABCA9	17	67016638	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	23789985	67016638	14178572	43	14108											
LIPG	9388	broad.mit.edu	37	chr18	47101837	47101837	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtcctccacacctacacgCgttccttcggcttgagcatt	7	15	0	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr18:47101837C>T	uc002ldv.2	+	5	922	c.670C>T	c.(670-672)CGT>TGT	p.R224C	LIPG_uc002ldu.1_Missense_Mutation_p.R224C|LIPG_uc010xdh.1_Intron	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	224					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						CACCTACACGCGTTCCTTCGG	0.557													T	47101837	T	T	47101837	3	4	199	1	0	0	0	0	1	0	0	0	8823	768	27	1	688	1	LIPG	18	47101837	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08		47101837	30975411	44	14109											
TUBB4	10382	broad.mit.edu	37	chr19	6495585	6495585	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcggccacggtcaggtagcGgccgtggcgcgggtcgcacg	20	13	1	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr19:6495585G>A	uc002mfg.1	-	4	1032	c.925C>T	c.(925-927)CGC>TGC	p.R309C	TUBB4_uc002mff.1_Missense_Mutation_p.R237C|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	309					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		GTCAGGTAGCGGCCGTGGCGC	0.662													A	6495585	A	A	6495585	3	1	199	1	0	0	0	0	1	0	0	0	16755	1116	39	2	413	2	TUBB4	19	6495585	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		6495585	52633398	45	14110											
MUC16	94025	broad.mit.edu	37	chr19	9073488	9073488	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaaaatatctgggaactttGttgactgagcaggagttggt	13	4	1	3			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr19:9073488G>T	uc002mkp.2	-	3	14162	c.13958C>A	c.(13957-13959)ACA>AAA	p.T4653K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4655	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGGAACTTTGTTGACTGAGC	0.458													T	9073488	T	T	9073488	3	4	199	1	0	0	0	0	1	0	0	0	9973	1377	48	5	29893	5	MUC16	19	9073488	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08	2577903	9073488	50055495	46	14111											
GRAMD1A	57655	broad.mit.edu	37	chr19	35500871	35500871	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccccgaagcagaacgcctcaTtgtgggtgagtcccggaccc	12	15	1	2			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr19:35500871T>C	uc010xse.1	+	4	457	c.320T>C	c.(319-321)ATT>ACT	p.I107T	GRAMD1A_uc002nxi.1_Missense_Mutation_p.I194T|GRAMD1A_uc002nxk.2_Missense_Mutation_p.I100T|GRAMD1A_uc002nxl.2_5'UTR|GRAMD1A_uc010xsf.1_Missense_Mutation_p.I112T	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	107	GRAM.					integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GAACGCCTCATTGTGGGTGAG	0.607													C	35500871	C	C	35500871	3	2	199	1	0	0	0	0	1	0	0	0	6747	1493	52	4	334	4	GRAMD1A	19	35500871	Missense_Mutation	SNP	T	TCGA-28-1747-01C-01D-1494-08	26427383	35500871	23628112	47	14112											
ZNF610	162963	broad.mit.edu	37	chr19	52868955	52868955	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctttcttcttttctagggagGagctgtgtattgggaagcaa	12	6	3	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr19:52868955G>A	uc002pyx.3	+	6	730	c.324G>A	c.(322-324)AGG>AGA	p.R108R	ZNF610_uc002pyy.3_Silent_p.R108R|ZNF610_uc002pyz.3_Silent_p.R65R|ZNF610_uc002pza.2_Silent_p.R108R	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		TTCTAGGGAGGAGCTGTGTAT	0.453													A	52868955	A	A	52868955	2	1	199	1	0	0	0	0	0	0	0	1	18033	1165	41	3		3	ZNF610	19	52868955	Silent	SNP	G	TCGA-28-1747-01C-01D-1494-08	17368084	52868955	6260028	48	14113											
PTPRH	5794	broad.mit.edu	37	chr19	55693262	55693262	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgcactgatgcaggaataCgtactgagcctgggaagcag	14	8	0	2	rs140496718		TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr19:55693262C>T	uc002qjq.2	-	20	3281	c.3208G>A	c.(3208-3210)GTA>ATA	p.V1070I	PTPRH_uc010esv.2_Missense_Mutation_p.V892I|SYT5_uc002qjm.1_5'Flank|SYT5_uc002qjp.2_5'Flank|SYT5_uc002qjn.1_5'Flank|SYT5_uc002qjo.1_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1070	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TGCAGGAATACGTACTGAGCC	0.622													T	55693262	T	T	55693262	3	4	199	1	0	0	0	0	1	0	0	0	12803	536	19	1	143	1	PTPRH	19	55693262	Missense_Mutation	SNP	C	TCGA-28-1747-01C-01D-1494-08	2824307	55693262	3435721	49	14114											
ANGPT4	51378	broad.mit.edu	37	chr20	853677	853677	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccttgaagtagtgccagcGgatgccgtccatcttgtact	11	12	1	1			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr20:853677G>A	uc002wei.2	-	9	1541	c.1438C>T	c.(1438-1440)CGC>TGC	p.R480C	ANGPT4_uc010zpn.1_3'UTR	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	480	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						TAGTGCCAGCGGATGCCGTCC	0.587													A	853677	A	A	853677	3	1	199	1	0	0	0	0	1	0	0	0	612	1116	39	2	77	2	ANGPT4	20	853677	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		853677	62171843	50	14115											
MOCS3	27304	broad.mit.edu	37	chr20	49576424	49576424	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agcgactgctggattctgggGcattccacctgttgctggac	13	11	1	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr20:49576424G>C	uc002xvy.1	+	1	1062	c.1045G>C	c.(1045-1047)GCA>CCA	p.A349P	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	349	Rhodanese.				enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						GGATTCTGGGGCATTCCACCT	0.552													C	49576424	C	C	49576424	3	2	199	1	0	0	0	0	1	0	0	0	9692	1203	42	5	1047	5	MOCS3	20	49576424	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08	48722747	49576424	13449096	51	14116											
TRPM2	7226	broad.mit.edu	37	chr21	45798938	45798938	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttgtggagggctcgggccGcgtggccgacgtcattgccc	18	12	1	0			TCGA-28-1747-01C-01D-1494-08	TCGA-28-1747-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	7c746081-ac14-4ae2-9564-d67d52f2627c	53b59edd-ae02-4865-8ee3-d8a0da64e9e9	g.chr21:45798938G>A	uc002zet.1	+	9	1286	c.1073G>A	c.(1072-1074)CGC>CAC	p.R358H	TRPM2_uc002zeu.1_Missense_Mutation_p.R358H|TRPM2_uc002zew.1_Missense_Mutation_p.R358H|TRPM2_uc010gpt.1_Missense_Mutation_p.R358H|TRPM2_uc002zex.1_Missense_Mutation_p.R144H	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	358	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCTCGGGCCGCGTGGCCGAC	0.622													A	45798938	A	A	45798938	3	1	199	1	0	0	0	0	1	0	0	0	16583	1087	38	1	1103	1	TRPM2	21	45798938	Missense_Mutation	SNP	G	TCGA-28-1747-01C-01D-1494-08		45798938	2330957	52	14117											
CROCC	9696	broad.mit.edu	37	chr1	17296756	17296756	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctgttgcaggtgctgcgGcagcggcaggagggtgaggc	19	9	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr1:17296756G>A	uc001azt.2	+	34	5529	c.5460G>A	c.(5458-5460)CGG>CGA	p.R1820R	CROCC_uc001azu.2_Silent_p.R1123R|CROCC_uc001azv.2_Silent_p.R156R	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1820					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		AGGTGCTGCGGCAGCGGCAGG	0.428													A	17296756	A	A	17296756	2	1	200	1	0	0	0	0	0	0	0	1	3893	1190	42	3		3	CROCC	1	17296756	Silent	SNP	G	TCGA-28-1753-01A-01D-1494-08		17296756	231953865	1	14118											
HCRTR1	3061	broad.mit.edu	37	chr1	32086485	32086485	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtgctaactctcagcttcatCgccctggaccgctggtatgc	10	14	2	0	rs140406432		TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr1:32086485C>T	uc009vtx.2	+	5	805	c.420C>T	c.(418-420)ATC>ATT	p.I140I	HCRTR1_uc001btb.2_5'UTR|HCRTR1_uc001btc.3_Silent_p.I54I|HCRTR1_uc001btd.2_Silent_p.I140I|HCRTR1_uc010ogl.1_Silent_p.I140I	NM_001525	NP_001516	O43613	OX1R_HUMAN	orexin receptor 1	140	Helical; Name=3; (Potential).				feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				ovary(1)	1		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		TCAGCTTCATCGCCCTGGACC	0.612													T	32086485	T	T	32086485	2	4	200	1	0	0	0	0	0	0	0	1	7001	874	31	2		2	HCRTR1	1	32086485	Silent	SNP	C	TCGA-28-1753-01A-01D-1494-08	14789729	32086485	217164136	2	14119											
PABPC4	8761	broad.mit.edu	37	chr1	40038250	40038250	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagttcatggtgtccaaagCccgctcagctgtaagagaga	11	9	2	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr1:40038250C>T	uc010oiv.1	-	2	1100	c.202G>A	c.(202-204)GCT>ACT	p.A68T	PABPC4_uc001cdl.2_Missense_Mutation_p.A68T|PABPC4_uc001cdm.2_Missense_Mutation_p.A68T	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	68	RRM 1.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GTGTCCAAAGCCCGCTCAGCT	0.463													T	40038250	T	T	40038250	3	4	200	1	0	0	0	0	1	0	0	0	11366	739	26	3	1836	3	PABPC4	1	40038250	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	7951765	40038250	209212371	3	14120											
CYP4X1	260293	broad.mit.edu	37	chr1	47512186	47512186	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacaatgtgcatcaaggagaCgtgccgattgattcctgcag	11	10	1	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr1:47512186C>T	uc001cqt.2	+	9	1371	c.1121C>T	c.(1120-1122)ACG>ATG	p.T374M	CYP4X1_uc001cqr.2_Missense_Mutation_p.T373M|CYP4X1_uc001cqs.2_Missense_Mutation_p.T309M	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	374						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						ATCAAGGAGACGTGCCGATTG	0.493													T	47512186	T	T	47512186	3	4	200	1	0	0	0	0	1	0	0	0	4193	536	19	1	1155	1	CYP4X1	1	47512186	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	7473936	47512186	201738435	4	14121											
CYP4A22	284541	broad.mit.edu	37	chr1	47606460	47606460	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcgttgacagttccaacaCgaccaggagctacaacggat	9	13	0	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr1:47606460C>T	uc001cqv.1	+	2	255	c.204C>T	c.(202-204)CAC>CAT	p.H68H	CYP4A22_uc009vyo.2_Silent_p.H68H|CYP4A22_uc009vyp.2_Silent_p.H68H	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	68						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						AGTTCCAACACGACCAGGAGC	0.498													T	47606460	T	T	47606460	2	4	200	1	0	0	0	0	0	0	0	1	4184	535	19	1		1	CYP4A22	1	47606460	Silent	SNP	C	TCGA-28-1753-01A-01D-1494-08	94274	47606460	201644161	5	14122											
CDKN2C	1031	broad.mit.edu	37	chr1	51439583	51439583	+	Frame_Shift_Del	DEL	C	-	-													aggttatgaaacttggaaatCccgagattgccaggagactg							TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr1:51439583delC	uc001csf.2	+	3	1364	c.148delC	c.(148-150)CCCfs	p.P50fs	CDKN2C_uc001csg.2_Frame_Shift_Del_p.P50fs	NM_001262	NP_001253	P42773	CDN2C_HUMAN	cyclin-dependent kinase inhibitor 2C	50	ANK 2.				cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0?(4)|p.?(1)		central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(5)|ovary(2)|thyroid(1)|lung(1)|kidney(1)	17				GBM - Glioblastoma multiforme(3;3.61e-13)|all cancers(3;0.00151)		ACTTGGAAATCCCGAGATTGC	0.428			D		glioma|MM				Multiple_Endocrine_Neoplasia_type_1				-	51439583	-	-	51439583	7	5	200	1	0	1	0	1	0	0	0	0	3165	855	30	0	154	0	CDKN2C	1	51439583	Frame_Shift_Del	DEL	C	TCGA-28-1753-01A-01D-1494-08	3833123	51439583	197811038	6	14123											
FCRLA	84824	broad.mit.edu	37	chr1	161682005	161682005	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagctagagatcagagtgCagggtgagttcgcatcagag	14	9	2	4			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr1:161682005C>T	uc001gbe.2	+	5	1092	c.850C>T	c.(850-852)CAG>TAG	p.Q284*	FCRLA_uc001gbd.2_Nonsense_Mutation_p.Q278*|FCRLA_uc001gbf.2_Nonsense_Mutation_p.Q189*|FCRLA_uc001gbg.2_Nonsense_Mutation_p.Q138*|FCRLA_uc009wuo.2_Nonsense_Mutation_p.Q144*|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	261					cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			GATCAGAGTGCAGGGTGAGTT	0.527													T	161682005	T	T	161682005	4	4	200	1	0	0	0	0	0	1	0	0	5800	711	25	3	868	3	FCRLA	1	161682005	Nonsense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	110242422	161682005	87568616	7	14124											
RYR2	6262	broad.mit.edu	37	chr1	237754030	237754030	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agaacagcaacactgatatcAtgttttatcgcctgagcatg	8	9	1	3			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr1:237754030A>G	uc001hyl.1	+	31	4018	c.3898A>G	c.(3898-3900)ATG>GTG	p.M1300V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1300	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CACTGATATCATGTTTTATCG	0.522													G	237754030	G	G	237754030	3	3	200	1	0	0	0	0	1	0	0	0	13769	217	8	4	4020	4	RYR2	1	237754030	Missense_Mutation	SNP	A	TCGA-28-1753-01A-01D-1494-08	76072025	237754030	11496591	8	14125											
TEKT4	150483	broad.mit.edu	37	chr2	95539765	95539765	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggtcagacaagatggagGcctacaacatcgacgagacc	11	11	1	3			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr2:95539765G>A	uc002stw.1	+	3	718	c.625G>A	c.(625-627)GCC>ACC	p.A209T	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	209					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						CAAGATGGAGGCCTACAACAT	0.652													A	95539765	A	A	95539765	3	1	200	1	0	0	0	0	1	0	0	0	15752	1203	42	3	635	3	TEKT4	2	95539765	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08		95539765	147659608	9	14126											
MARCO	8685	broad.mit.edu	37	chr2	119752091	119752091	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgcaggcgtggagtgcagcGtctgacccggaaaccctttc	13	13	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr2:119752091G>A	uc002tln.1	+	17	1690	c.1558G>A	c.(1558-1560)GTC>ATC	p.V520I	MARCO_uc010yyf.1_Missense_Mutation_p.V442I	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	520	Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGAGTGCAGCGTCTGACCCGG	0.602													A	119752091	A	A	119752091	3	1	200	1	0	0	0	0	1	0	0	0	9311	1145	40	1	1624	1	MARCO	2	119752091	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08	24212326	119752091	123447282	10	14127											
NEB	4703	broad.mit.edu	37	chr2	152484105	152484105	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtcgggcaggcacgtccactCgtgcaggtagttcttgtagt	14	10	1	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr2:152484105C>T	uc010fnx.2	-	65	9537	c.9346G>A	c.(9346-9348)GAG>AAG	p.E3116K		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3116	Nebulin 84.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CACGTCCACTCGTGCAGGTAG	0.532													T	152484105	T	T	152484105	3	4	200	1	0	0	0	0	1	0	0	0	10302	893	31	2	16067	2	NEB	2	152484105	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	32732014	152484105	90715268	11	14128											
LRP2	4036	broad.mit.edu	37	chr2	170044684	170044684	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttttactaatgcagcgccCgttctgacaggtaaactgat	10	9	1	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr2:170044684C>T	uc002ues.2	-	49	9337	c.9124G>A	c.(9124-9126)GGG>AGG	p.G3042R		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3042	LDL-receptor class A 24.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATGCAGCGCCCGTTCTGACAG	0.512													T	170044684	T	T	170044684	3	4	200	1	0	0	0	0	1	0	0	0	8956	652	23	2	4967	2	LRP2	2	170044684	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	17560579	170044684	73154689	12	14129											
TTN	7273	broad.mit.edu	37	chr2	179437646	179437646	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggcaggttccccaagtccttCggaattcatggcatagatgc	11	11	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr2:179437646C>T	uc010zfg.1	-	275	65733	c.65509G>A	c.(65509-65511)GAA>AAA	p.E21837K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E15532K|TTN_uc010zfi.1_Missense_Mutation_p.E15465K|TTN_uc010zfj.1_Missense_Mutation_p.E15340K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22764							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAAGTCCTTCGGAATTCATG	0.488													T	179437646	T	T	179437646	3	4	200	1	0	0	0	0	1	0	0	0	16732	893	31	2	34914	2	TTN	2	179437646	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	9392962	179437646	63761727	13	14130											
ITGA4	3676	broad.mit.edu	37	chr2	182360569	182360569	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgagtcagtaaatagaaCgaaatttgactgtgttgaaa	9	6	1	4			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr2:182360569C>T	uc002unu.2	+	14	2208	c.1445C>T	c.(1444-1446)ACG>ATG	p.T482M	ITGA4_uc010frj.1_5'Flank	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	482	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GTAAATAGAACGAAATTTGAC	0.388													T	182360569	T	T	182360569	3	4	200	1	0	0	0	0	1	0	0	0	7878	536	19	1	1499	1	ITGA4	2	182360569	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	2922923	182360569	60838804	14	14131											
BARD1	580	broad.mit.edu	37	chr2	215646041	215646041	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaaacatctgcaggaggaCttggggaaacaaattcatat	10	7	2	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr2:215646041C>T	uc002veu.2	-	4	692	c.557G>A	c.(556-558)AGT>AAT	p.S186N	BARD1_uc010zjm.1_Missense_Mutation_p.S42N	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	186					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGCAGGAGGACTTGGGGAAAC	0.383									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				T	215646041	T	T	215646041	3	4	200	1	0	0	0	0	1	0	0	0	1312	565	20	3	1808	3	BARD1	2	215646041	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	33285472	215646041	27553332	15	14132											
SPEG	10290	broad.mit.edu	37	chr2	220342016	220342016	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggacgaggtgctgctgacCgagagcagccatgtgagctt	15	10	0	3			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr2:220342016C>T	uc010fwg.2	+	20	4578	c.4578C>T	c.(4576-4578)ACC>ACT	p.T1526T		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1526	Ig-like 8.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TGCTGCTGACCGAGAGCAGCC	0.642													T	220342016	T	T	220342016	2	4	200	1	0	0	0	0	0	0	0	1	15035	639	23	2		2	SPEG	2	220342016	Silent	SNP	C	TCGA-28-1753-01A-01D-1494-08	4695975	220342016	22857357	16	14133											
FGD5	152273	broad.mit.edu	37	chr3	14861789	14861789	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggctccctacagggtggagCggccgagggtcccgcagccc	16	15	0	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr3:14861789C>T	uc003bzc.2	+	1	1321	c.1211C>T	c.(1210-1212)GCG>GTG	p.A404V	FGD5_uc011avk.1_Missense_Mutation_p.A404V	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	404					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CAGGGTGGAGCGGCCGAGGGT	0.647													T	14861789	T	T	14861789	3	4	200	1	0	0	0	0	1	0	0	0	5836	768	27	1	1213	1	FGD5	3	14861789	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08		14861789	183160641	17	14134											
CD86	942	broad.mit.edu	37	chr3	121822548	121822548	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcattccaagtatatgggccGcacaagttttgattcggaca	9	9	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr3:121822548G>A	uc003eet.2	+	3	370	c.254G>A	c.(253-255)CGC>CAC	p.R85H	CD86_uc011bjo.1_Missense_Mutation_p.R3H|CD86_uc011bjp.1_Intron|CD86_uc003eeu.2_Missense_Mutation_p.R79H	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	85	Ig-like V-type.|Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	TATATGGGCCGCACAAGTTTT	0.423													A	121822548	A	A	121822548	3	1	200	1	0	0	0	0	1	0	0	0	3043	1087	38	1	264	1	CD86	3	121822548	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08	106960759	121822548	76199882	18	14135											
SLBP	7884	broad.mit.edu	37	chr4	1701407	1701407	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtcagccggcacagtagaCatagactcctttgaatcaga	9	10	2	4			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr4:1701407C>T	uc003gdi.1	-	5	478	c.363G>A	c.(361-363)ATG>ATA	p.M121I	SLBP_uc010ibx.1_Missense_Mutation_p.M128I|SLBP_uc003gdj.1_Missense_Mutation_p.M101I|SLBP_uc003gdk.1_Missense_Mutation_p.M82I|SLBP_uc011bvf.1_Missense_Mutation_p.M86I|SLBP_uc003gdl.1_Missense_Mutation_p.M38I	NM_006527	NP_006518	Q14493	SLBP_HUMAN	stem-loop (histone) binding protein	121					DNA replication involved in S phase|histone mRNA 3'-end processing|mRNA export from nucleus|regulation of S phase|termination of RNA polymerase II transcription	cytosol|histone pre-mRNA 3'end processing complex|nucleoplasm	histone pre-mRNA DCP binding|histone pre-mRNA stem-loop binding|protein binding				0		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.0055)			GCACAGTAGACATAGACTCCT	0.393													T	1701407	T	T	1701407	3	4	200	1	0	0	0	0	1	0	0	0	14372	478	17	3	465	3	SLBP	4	1701407	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08		1701407	189452869	19	14136											
ANK2	287	broad.mit.edu	37	chr4	114278539	114278539	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaatgatgaaatctatgatcCacaaatcactagcccttatg	6	9	2	3			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr4:114278539C>T	uc003ibe.3	+	38	8865	c.8765C>T	c.(8764-8766)CCA>CTA	p.P2922L	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.P224L|ANK2_uc011cgb.1_Missense_Mutation_p.P2937L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2889					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCTATGATCCACAAATCACT	0.408													T	114278539	T	T	114278539	3	4	200	1	0	0	0	0	1	0	0	0	621	594	21	3	8980	3	ANK2	4	114278539	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	112577132	114278539	76875737	20	14137											
ZFP42	132625	broad.mit.edu	37	chr4	188924445	188924445	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaggaatacctggcattgacCtatcagatcctaaacagctc	8	11	1	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr4:188924445C>G	uc003izg.1	+	3	729	c.484C>G	c.(484-486)CTA>GTA	p.L162V	ZFP42_uc003izh.1_Missense_Mutation_p.L162V|ZFP42_uc003izi.1_Missense_Mutation_p.L162V	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	162					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TGGCATTGACCTATCAGATCC	0.453													G	188924445	G	G	188924445	3	3	200	1	0	0	0	0	1	0	0	0	17647	680	24	5	486	5	ZFP42	4	188924445	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	74645906	188924445	2229831	21	14138											
PCDHB16	57717	broad.mit.edu	37	chr5	140563779	140563779	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcagcgaggcgctggtgcgcGtgctggtgctggacgccaac	18	12	0	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr5:140563779G>T	uc003liv.2	+	1	2800	c.1645G>T	c.(1645-1647)GTG>TTG	p.V549L		NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	549	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGGTGCGCGTGCTGGTGCT	0.711													T	140563779	T	T	140563779	3	4	200	1	0	0	0	0	1	0	0	0	11541	1145	40	5	1647	5	PCDHB16	5	140563779	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08		140563779	40351481	22	14139											
GABRG2	2566	broad.mit.edu	37	chr5	161580200	161580200	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacggctatgagtgtctggaCggcaaggactgtgccagttt	14	8	1	1	rs113085352		TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr5:161580200C>T	uc003lyz.3	+	9	1588	c.1230C>T	c.(1228-1230)GAC>GAT	p.D410D	GABRG2_uc010jjc.2_Silent_p.D458D|GABRG2_uc003lyy.3_Silent_p.D418D|GABRG2_uc011dej.1_Silent_p.D315D	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	410	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		AGTGTCTGGACGGCAAGGACT	0.463													T	161580200	T	T	161580200	2	4	200	1	0	0	0	0	0	0	0	1	6172	535	19	1		1	GABRG2	5	161580200	Silent	SNP	C	TCGA-28-1753-01A-01D-1494-08	21016421	161580200	19335060	23	14140											
RFX6	222546	broad.mit.edu	37	chr6	117232121	117232121	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcttcactcgtaaatattcGcttagctcaaaaactggaac	7	10	2	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr6:117232121G>A	uc003pxm.2	+	7	759	c.696G>A	c.(694-696)TCG>TCA	p.S232S		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	232					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GTAAATATTCGCTTAGCTCAA	0.343													A	117232121	A	A	117232121	2	1	200	1	0	0	0	0	0	0	0	1	13267	1074	38	1		1	RFX6	6	117232121	Silent	SNP	G	TCGA-28-1753-01A-01D-1494-08		117232121	53882946	24	14141											
CD36	948	broad.mit.edu	37	chr7	80300317	80300317	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctatgctgtatttgaatcCgacgttaatctgaaaggaat	8	6	2	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr7:80300317C>T	uc003uhc.2	+	13	1527	c.843C>T	c.(841-843)TCC>TCT	p.S281S	CD36_uc003uhd.3_Silent_p.S281S|CD36_uc011kgv.1_Silent_p.S205S|CD36_uc003uhe.3_Silent_p.S281S|CD36_uc003uhf.3_Silent_p.S281S|CD36_uc003uhg.3_Silent_p.S281S|CD36_uc003uhh.3_Silent_p.S281S	NM_001127444	NP_001120916	P16671	CD36_HUMAN	CD36 antigen	281	Extracellular (Potential).				cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			ovary(1)	1						TATTTGAATCCGACGTTAATC	0.388													T	80300317	T	T	80300317	2	4	200	1	0	0	0	0	0	0	0	1	3007	639	23	2		2	CD36	7	80300317	Silent	SNP	C	TCGA-28-1753-01A-01D-1494-08		80300317	78838346	25	14142											
SEMA3C	10512	broad.mit.edu	37	chr7	80434993	80434993	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgttgatcagttctgaccGcattcctcttggttaaactt	7	9	3	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr7:80434993G>A	uc003uhj.2	-	7	1182	c.620C>T	c.(619-621)GCG>GTG	p.A207V	SEMA3C_uc011kgw.1_Missense_Mutation_p.A225V|SEMA3C_uc011kgx.1_Missense_Mutation_p.A59V	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	207	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						AGTTCTGACCGCATTCCTCTT	0.323													A	80434993	A	A	80434993	3	1	200	1	0	0	0	0	1	0	0	0	14026	1087	38	1	1683	1	SEMA3C	7	80434993	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08	134676	80434993	78703670	26	14143											
TES	26136	broad.mit.edu	37	chr7	115892026	115892026	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccgatgtgctggctgtgaCgaggtatgttctatgggacc	14	10	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr7:115892026C>T	uc003vho.2	+	5	1096	c.915C>T	c.(913-915)GAC>GAT	p.D305D	TES_uc011kmy.1_Silent_p.D63D|TES_uc003vhp.2_Silent_p.D296D|uc003vhq.1_5'Flank	NM_015641	NP_056456	Q9UGI8	TES_HUMAN	testin isoform 1	305	LIM zinc-binding 2.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding				0	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			CTGGCTGTGACGAGGTATGTT	0.478													T	115892026	T	T	115892026	2	4	200	1	0	0	0	0	0	0	0	1	15762	535	19	1		1	TES	7	115892026	Silent	SNP	C	TCGA-28-1753-01A-01D-1494-08	35457033	115892026	43246637	27	14144											
WEE2	494551	broad.mit.edu	37	chr7	141408767	141408767	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcatgagctcgacacatcttCggaaaaagacaaagaaagtc	9	9	1	3			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr7:141408767C>T	uc003vwn.2	+	1	615	c.209C>T	c.(208-210)TCG>TTG	p.S70L	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	70					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					GACACATCTTCGGAAAAAGAC	0.517													T	141408767	T	T	141408767	3	4	200	1	0	0	0	0	1	0	0	0	17342	893	31	2	211	2	WEE2	7	141408767	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	25516741	141408767	17729896	28	14145											
ARHGEF5	7984	broad.mit.edu	37	chr7	144060365	144060365	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagaatgaaggctctgaaagTgggactatcaggcaggggga	16	6	2	3			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr7:144060365T>A	uc003wel.2	+	2	721	c.603T>A	c.(601-603)AGT>AGA	p.S201R	ARHGEF5_uc003wek.2_Missense_Mutation_p.S201R	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	201					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					GCTCTGAAAGTGGGACTATCA	0.532													A	144060365	A	A	144060365	3	1	200	1	0	0	0	0	1	0	0	0	909	1693	59	5	605	5	ARHGEF5	7	144060365	Missense_Mutation	SNP	T	TCGA-28-1753-01A-01D-1494-08	2651598	144060365	15078298	29	14146											
DOCK5	80005	broad.mit.edu	37	chr8	25190203	25190203	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgacttccttgtgtttgacGcactggtaagcagttaaaca	9	8	0	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr8:25190203G>A	uc003xeg.2	+	20	2223	c.2086G>A	c.(2086-2088)GCA>ACA	p.A696T	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.A410T|DOCK5_uc003xei.2_Missense_Mutation_p.A266T|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	696						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TGTGTTTGACGCACTGGTAAG	0.214													A	25190203	A	A	25190203	3	1	200	1	0	0	0	0	1	0	0	0	4690	1087	38	1	2164	1	DOCK5	8	25190203	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08		25190203	121173819	30	14147											
DOCK5	80005	broad.mit.edu	37	chr8	25225732	25225732	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggggacatgagaaaggaaatCggctttagaatccgggacat	14	6	0	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr8:25225732C>T	uc003xeg.2	+	32	3386	c.3249C>T	c.(3247-3249)ATC>ATT	p.I1083I	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Silent_p.I797I|DOCK5_uc003xei.2_Silent_p.I653I|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1083						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GAAAGGAAATCGGCTTTAGAA	0.413													T	25225732	T	T	25225732	2	4	200	1	0	0	0	0	0	0	0	1	4690	874	31	2		2	DOCK5	8	25225732	Silent	SNP	C	TCGA-28-1753-01A-01D-1494-08	35529	25225732	121138290	31	14148											
NOV	4856	broad.mit.edu	37	chr8	120431487	120431487	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggtatggggttctccaccCgggtcaccaataggaaccgt	13	11	2	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr8:120431487C>T	uc003yoq.2	+	4	900	c.679C>T	c.(679-681)CGG>TGG	p.R227W		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	227	TSP type-1.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GTTCTCCACCCGGGTCACCAA	0.532													T	120431487	T	T	120431487	3	4	200	1	0	0	0	0	1	0	0	0	10553	643	23	2	693	2	NOV	8	120431487	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	95205755	120431487	25932535	32	14149											
CPSF1	29894	broad.mit.edu	37	chr8	145620691	145620691	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacatagtgggccgtgcagcGcagcgggatcttcctgacag	14	12	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr8:145620691G>A	uc003zcj.2	-	27	3130	c.3055C>T	c.(3055-3057)CGC>TGC	p.R1019C	MIR939_hsa-mir-939|MI0005761_5'Flank|CPSF1_uc011lld.1_RNA	NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	1019					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GCCGTGCAGCGCAGCGGGATC	0.667													A	145620691	A	A	145620691	3	1	200	1	0	0	0	0	1	0	0	0	3824	1087	38	1	1324	1	CPSF1	8	145620691	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08	25189204	145620691	743331	33	14150											
UHRF2	115426	broad.mit.edu	37	chr9	6413501	6413501	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggcgccaagatgtggatacAggttcgcaccattgatggct	13	9	0	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr9:6413501A>G	uc003zjy.2	+	1	351	c.11A>G	c.(10-12)CAG>CGG	p.Q4R	UHRF2_uc003zjz.2_RNA	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	4	Ubiquitin-like.				cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		ATGTGGATACAGGTTCGCACC	0.512													G	6413501	G	G	6413501	3	3	200	1	0	0	0	0	1	0	0	0	16967	188	7	4	13	4	UHRF2	9	6413501	Missense_Mutation	SNP	A	TCGA-28-1753-01A-01D-1494-08		6413501	134799930	34	14151											
IPPK	64768	broad.mit.edu	37	chr9	95400529	95400529	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtcagccacggggctccGggcatctttgcagccgtaaa	12	14	2	0	rs146634367		TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr9:95400529G>A	uc004asl.1	-	9	947	c.670C>T	c.(670-672)CGG>TGG	p.R224W	IPPK_uc004ask.1_5'Flank	NM_022755	NP_073592	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	224					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			ovary(2)	2						ACGGGGCTCCGGGCATCTTTG	0.562													A	95400529	A	A	95400529	3	1	200	1	0	0	0	0	1	0	0	0	7801	1115	39	2	825	2	IPPK	9	95400529	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08	88987028	95400529	45812902	35	14152											
KIF5B	3799	broad.mit.edu	37	chr10	32306085	32306085	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actaaccaatctgtgcagaaTgccctcttctggccatattc	6	13	3	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr10:32306085T>C	uc001iwe.3	-	24	3217	c.2747A>G	c.(2746-2748)CAT>CGT	p.H916R		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	916	Globular.				stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)				CTGTGCAGAATGCCCTCTTCT	0.383													C	32306085	C	C	32306085	3	2	200	1	0	0	0	0	1	0	0	0	8306	1464	51	4	152	4	KIF5B	10	32306085	Missense_Mutation	SNP	T	TCGA-28-1753-01A-01D-1494-08		32306085	103228662	36	14153											
PTEN	5728	broad.mit.edu	37	chr10	89720857	89720857	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaagacaaagccaaccgataCttttctccaaattttaaggt	5	9	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr10:89720857C>A	uc001kfb.2	+	9	2039	c.1008C>A	c.(1006-1008)TAC>TAA	p.Y336*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	336	C2 tensin-type.			Y->F: Significantly lower phosphatase activity, reduced protein stability and decreased growth-inhibitory effect.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.Y336*(3)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.Y336F(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.R335fs*4(1)|p.W274_F341del(1)|p.D326_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CCAACCGATACTTTTCTCCAA	0.333		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89720857	A	A	89720857	4	1	200	1	0	0	0	0	0	1	0	0	12738	576	20	5	1038	5	PTEN	10	89720857	Nonsense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	57414772	89720857	45813890	37	14154											
SLC6A13	6540	broad.mit.edu	37	chr12	333249	333249	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcttgcggaacacgtgaGggtacatgtccaccagcgct	11	12	2	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr12:333249G>A	uc001qic.1	-	11	1273	c.1220C>T	c.(1219-1221)CCT>CTT	p.P407L	SLC6A13_uc009zdj.1_Missense_Mutation_p.P397L|SLC6A13_uc010sdl.1_Missense_Mutation_p.P315L	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	407					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GAACACGTGAGGGTACATGTC	0.562													A	333249	A	A	333249	3	1	200	1	0	0	0	0	1	0	0	0	14676	1000	35	3	608	3	SLC6A13	12	333249	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08		333249	133518646	38	14155											
LST-3TM12	338821	broad.mit.edu	37	chr12	21201718	21201718	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cattaaaaaattcaaattgtCtttagttggacttgccaaat	5	6	2	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr12:21201718C>T	uc010sin.1	+	8	1067	c.1067C>T	c.(1066-1068)TCT>TTT	p.S356F	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Missense_Mutation_p.S403F	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	356						membrane	transporter activity				0						TTCAAATTGTCTTTAGTTGGA	0.353													T	21201718	T	T	21201718	3	4	200	1	0	0	0	0	1	0	0	0	9066	913	32	3	1097	3	LST-3TM12	12	21201718	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	20868469	21201718	112650177	39	14156											
E2F7	144455	broad.mit.edu	37	chr12	77426878	77426878	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agacagctgccaggcttccaAtttctaaagagtagccacct	8	12	1	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr12:77426878A>G	uc001sym.3	-	9	1570	c.1334T>C	c.(1333-1335)ATT>ACT	p.I445T	E2F7_uc009zse.2_5'Flank	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	445					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						CAGGCTTCCAATTTCTAAAGA	0.353													G	77426878	G	G	77426878	3	3	200	1	0	0	0	0	1	0	0	0	4872	101	4	4	1421	4	E2F7	12	77426878	Missense_Mutation	SNP	A	TCGA-28-1753-01A-01D-1494-08	56225160	77426878	56425017	40	14157											
RPH3A	22895	broad.mit.edu	37	chr12	113313505	113313505	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccccaggaggaagcagacCgggtcctgggccagcaggac	16	13	0	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr12:113313505C>T	uc010syl.1	+	12	1267	c.905C>T	c.(904-906)CCG>CTG	p.P302L	RPH3A_uc001ttz.2_Missense_Mutation_p.P302L|RPH3A_uc001tty.2_Missense_Mutation_p.P298L|RPH3A_uc009zwe.1_Missense_Mutation_p.P298L|RPH3A_uc010sym.1_Missense_Mutation_p.P253L|RPH3A_uc001tua.2_Missense_Mutation_p.P62L	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	302	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GGAAGCAGACCGGGTCCTGGG	0.577													T	113313505	T	T	113313505	3	4	200	1	0	0	0	0	1	0	0	0	13551	652	23	2	943	2	RPH3A	12	113313505	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	35886627	113313505	20538390	41	14158											
SLC7A1	6541	broad.mit.edu	37	chr13	30110213	30110213	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcccaccccgagggccAccagatcaaaagtgttcagg	11	14	2	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr13:30110213A>G	uc001uso.2	-	3	500	c.113T>C	c.(112-114)GTG>GCG	p.V38A		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	38	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CCCGAGGGCCACCAGATCAAA	0.627													G	30110213	G	G	30110213	3	3	200	1	0	0	0	0	1	0	0	0	14692	159	6	4	1820	4	SLC7A1	13	30110213	Missense_Mutation	SNP	A	TCGA-28-1753-01A-01D-1494-08		30110213	85059665	42	14159											
SPERT	220082	broad.mit.edu	37	chr13	46287863	46287863	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtgaagaaggaccacgtcGccctgcaggtgccccgtggc	15	13	0	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr13:46287863G>A	uc001van.1	+	3	783	c.703G>A	c.(703-705)GCC>ACC	p.A235T	SPERT_uc001vao.2_Missense_Mutation_p.A199T	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	235						cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		GGACCACGTCGCCCTGCAGGT	0.677													A	46287863	A	A	46287863	3	1	200	1	0	0	0	0	1	0	0	0	15038	1087	38	1	713	1	SPERT	13	46287863	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08	16177650	46287863	68882015	43	14160											
C15orf2	23742	broad.mit.edu	37	chr15	24921157	24921157	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acccaccccgcgccctttccGcggcctgttccgccggaacg	10	21	0	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr15:24921157G>A	uc001ywo.2	+	1	617	c.143G>A	c.(142-144)CGC>CAC	p.R48H		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	48					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CGCCCTTTCCGCGGCCTGTTC	0.761													A	24921157	A	A	24921157	3	1	200	1	0	0	0	0	1	0	0	0	1784	1087	38	1	145	1	C15orf2	15	24921157	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08		24921157	77610235	44	14161											
SPPL2A	84888	broad.mit.edu	37	chr15	51031880	51031880	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaatatgacttcttacccaAccatttgtagaagaaataaa	4	7	1	3			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr15:51031880A>G	uc001zyv.2	-	6	910	c.730T>C	c.(730-732)TTG>CTG	p.L244L		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	244						integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		TTCTTACCCAACCATTTGTAG	0.308													G	51031880	G	G	51031880	2	3	200	1	0	0	0	0	0	0	0	1	15087	40	2	4		4	SPPL2A	15	51031880	Silent	SNP	A	TCGA-28-1753-01A-01D-1494-08	26110723	51031880	51499512	45	14162											
LARP6	55323	broad.mit.edu	37	chr15	71128745	71128745	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcatcagaaaagtagaattcGatctgatccaccagtttctt	6	9	4	3			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr15:71128745G>A	uc002ass.2	-	2	371	c.300C>T	c.(298-300)ATC>ATT	p.I100I		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	100	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						AGTAGAATTCGATCTGATCCA	0.502													A	71128745	A	A	71128745	2	1	200	1	0	0	0	0	0	0	0	1	8632	1048	37	2		2	LARP6	15	71128745	Silent	SNP	G	TCGA-28-1753-01A-01D-1494-08	20096865	71128745	31402647	46	14163											
MSLNL	401827	broad.mit.edu	37	chr16	820272	820272	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggcccagcagcgcagtcaCgttgccaacatccaggctct	11	15	2	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr16:820272C>T	uc002cjz.1	-	15	2713	c.2713G>A	c.(2713-2715)GTG>ATG	p.V905M	MIR662_hsa-mir-662|MI0003670_RNA	NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	554	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						AGCGCAGTCACGTTGCCAACA	0.692													T	820272	T	T	820272	3	4	200	1	0	0	0	0	1	0	0	0	9882	536	19	1	456	1	MSLNL	16	820272	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08		820272	89534481	47	14164											
OSGIN1	29948	broad.mit.edu	37	chr16	83994249	83994249	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctctttgatgcccttctaCgcccagacacagactttggg	9	13	2	3	rs62640906	byFrequency	TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr16:83994249C>T	uc002fha.2	+	5	912	c.529C>T	c.(529-531)CGC>TGC	p.R177C	OSGIN1_uc002fhb.2_Missense_Mutation_p.R94C|OSGIN1_uc002fhc.2_Missense_Mutation_p.R94C	NM_013370	NP_037502	Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	177					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity				0						TGCCCTTCTACGCCCAGACAC	0.632													T	83994249	T	T	83994249	3	4	200	1	0	0	0	0	1	0	0	0	11289	536	19	1	547	1	OSGIN1	16	83994249	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	83173977	83994249	6360504	48	14165											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	8	15	1	0	rs28934576	by1000genomes	TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577120	T	T	7577120	3	4	200	1	0	0	0	0	1	0	0	0	16378	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08		7577120	73618090	49	14166											
SGK494	124923	broad.mit.edu	37	chr17	26939067	26939067	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcacttaactctaccttcaCatctcgatgcatgatgccca	5	14	3	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr17:26939067C>T	uc002hbr.1	-	7	720	c.688G>A	c.(688-690)GTG>ATG	p.V230M	SGK494_uc010waq.1_Intron|SGK494_uc010war.1_RNA|uc010crq.1_5'Flank|uc002hbs.1_RNA	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						TCTACCTTCACATCTCGATGC	0.443													T	26939067	T	T	26939067	3	4	200	1	0	0	0	0	1	0	0	0	14213	478	17	3	568	3	SGK494	17	26939067	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	19361947	26939067	54256143	50	14167											
KIF2B	84643	broad.mit.edu	37	chr17	51901460	51901460	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acctcaaagtctatgggacaTtttttgagatttatgggggc	11	6	2	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr17:51901460T>A	uc002iua.2	+	1	1222	c.1066T>A	c.(1066-1068)TTT>ATT	p.F356I	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	356	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CTATGGGACATTTTTTGAGAT	0.453													A	51901460	A	A	51901460	3	1	200	1	0	0	0	0	1	0	0	0	8298	1493	52	5	1068	5	KIF2B	17	51901460	Missense_Mutation	SNP	T	TCGA-28-1753-01A-01D-1494-08	24962393	51901460	29293750	51	14168											
USH1G	124590	broad.mit.edu	37	chr17	72916669	72916669	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggcaccagatgttggctcCgaaggacaccaggaaggaca	13	10	0	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr17:72916669C>T	uc002jme.1	-	2	445	c.262G>A	c.(262-264)GGA>AGA	p.G88R	USH1G_uc010wro.1_5'UTR	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	88	ANK 2.				equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					ATGTTGGCTCCGAAGGACACC	0.602													T	72916669	T	T	72916669	3	4	200	1	0	0	0	0	1	0	0	0	17032	661	23	2	1131	2	USH1G	17	72916669	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	21015209	72916669	8278541	52	14169											
DNAH17	8632	broad.mit.edu	37	chr17	76502887	76502887	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggggaaagccagtcttttcGtctctaaatactctgccaaa	9	10	3	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr17:76502887G>A	uc010wtu.1	-	4	770	c.593C>T	c.(592-594)ACG>ATG	p.T198M						full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGTCTTTTCGTCTCTAAATA	0.557													A	76502887	A	A	76502887	3	1	200	1	0	0	0	0	1	0	0	0	4601	1145	40	1	8878	1	DNAH17	17	76502887	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08	3586218	76502887	4692323	53	14170											
SIPA1L3	23094	broad.mit.edu	37	chr19	38655177	38655177	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctctccagcaacgcatccaGcagccacagcgacgaccgct	8	19	1	0			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr19:38655177G>T	uc002ohk.2	+	15	4348	c.3839G>T	c.(3838-3840)AGC>ATC	p.S1280I		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1280					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AACGCATCCAGCAGCCACAGC	0.607													T	38655177	T	T	38655177	3	4	200	1	0	0	0	0	1	0	0	0	14331	971	34	5	3889	5	SIPA1L3	19	38655177	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08		38655177	20473806	54	14171											
LILRB2	10288	broad.mit.edu	37	chr19	54780739	54780739	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggaggagcagtaggacgaCggccaccaagatgccgatca	15	10	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr19:54780739C>T	uc002qfb.2	-	10	1671	c.1405G>A	c.(1405-1407)GTC>ATC	p.V469I	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.V469I|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.V468I|LILRB2_uc010yet.1_Missense_Mutation_p.V353I	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	469	Helical; (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		agtaggaCGACGGCCACCAAG	0.413													T	54780739	T	T	54780739	3	4	200	1	0	0	0	0	1	0	0	0	8791	536	19	1	411	1	LILRB2	19	54780739	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	16125562	54780739	4348244	55	14172											
LILRB1	10859	broad.mit.edu	37	chr19	55146136	55146136	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatcggcatcttggtggccGtcatcctactgctcctcctc	9	15	2	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr19:55146136G>A	uc002qgj.2	+	11	1745	c.1405G>A	c.(1405-1407)GTC>ATC	p.V469I	LILRB1_uc010erp.1_Missense_Mutation_p.V84I|LILRB1_uc002qgl.2_Missense_Mutation_p.V469I|LILRB1_uc002qgk.2_Missense_Mutation_p.V470I|LILRB1_uc002qgm.2_Missense_Mutation_p.V470I|LILRB1_uc010erq.2_Missense_Mutation_p.V453I|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	469	Helical; (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CTTGGTGGCCGTCAtcctact	0.413										HNSCC(37;0.09)			A	55146136	A	A	55146136	3	1	200	1	0	0	0	0	1	0	0	0	8790	1145	40	1	1442	1	LILRB1	19	55146136	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08	365397	55146136	3982847	56	14173											
TPTE	7179	broad.mit.edu	37	chr21	10951337	10951337	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctagagaaatagaacgataCtccaaaggaatataaagttt	8	5	0	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr21:10951337C>T	uc002yip.1	-	10	743	c.375G>A	c.(373-375)GAG>GAA	p.E125E	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.E107E|TPTE_uc002yir.1_Silent_p.E87E|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	125					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAGAACGATACTCCAAAGGAA	0.328													T	10951337	T	T	10951337	2	4	200	1	0	0	0	0	0	0	0	1	16427	564	20	3		3	TPTE	21	10951337	Silent	SNP	C	TCGA-28-1753-01A-01D-1494-08		10951337	37178558	57	14174											
KRTAP6-1	337966	broad.mit.edu	37	chr21	31986020	31986020	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggcatcctcaataatagtaGccagagccagagccgcatcc	9	13	1	2			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr21:31986020G>T	uc002yop.2	-	1	204	c.204C>A	c.(202-204)GGC>GGA	p.G68G	KRTAP20-1_uc011ade.1_5'Flank	NM_181602	NP_853633	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1	68						cytosol|intermediate filament					0						AATAATAGTAGCCAGAGCCAG	0.537													T	31986020	T	T	31986020	2	4	200	1	0	0	0	0	0	0	0	1	8569	958	34	5		5	KRTAP6-1	21	31986020	Silent	SNP	G	TCGA-28-1753-01A-01D-1494-08	21034683	31986020	16143875	58	14175											
ITSN1	6453	broad.mit.edu	37	chr21	35254584	35254584	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgaccaattgcttggggcCgcgcaaatttctgcacagtg	12	10	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr21:35254584C>T	uc002yta.1	+	35	4647	c.4379C>T	c.(4378-4380)CCG>CTG	p.P1460L	DONSON_uc002ysn.1_Intron|ITSN1_uc002ytb.1_Missense_Mutation_p.P1455L|ITSN1_uc002ytj.2_Missense_Mutation_p.P1399L|ITSN1_uc010gmm.1_RNA|ITSN1_uc010gmn.1_Intron|ITSN1_uc002ytk.1_Intron	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1460					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						TGCTTGGGGCCGCGCAAATTT	0.473													T	35254584	T	T	35254584	3	4	200	1	0	0	0	0	1	0	0	0	7926	652	23	2	4519	2	ITSN1	21	35254584	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	3268564	35254584	12875311	59	14176											
DIP2A	23181	broad.mit.edu	37	chr21	47957153	47957153	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagctgaaacattaacaaaCgtgctggatttcaaaaggga	10	7	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr21:47957153C>T	uc002zjo.2	+	14	1842	c.1659C>T	c.(1657-1659)AAC>AAT	p.N553N	DIP2A_uc011afy.1_Silent_p.N489N|DIP2A_uc011afz.1_Silent_p.N549N|DIP2A_uc002zjl.2_Silent_p.N553N|DIP2A_uc002zjm.2_Silent_p.N553N|DIP2A_uc010gql.2_Silent_p.N510N|DIP2A_uc002zjn.2_Silent_p.N553N|DIP2A_uc002zjp.1_Silent_p.N298N|DIP2A_uc002zjq.2_5'Flank	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	553					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CATTAACAAACGTGCTGGATT	0.443													T	47957153	T	T	47957153	2	4	200	1	0	0	0	0	0	0	0	1	4527	535	19	1		1	DIP2A	21	47957153	Silent	SNP	C	TCGA-28-1753-01A-01D-1494-08	12702569	47957153	172742	60	14177											
SUSD2	56241	broad.mit.edu	37	chr22	24582099	24582099	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgacctgagggtgcaggcGcgggcccagcccgggacgat	17	14	0	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chr22:24582099G>A	uc002zzn.1	+	9	1499	c.1455G>A	c.(1453-1455)GCG>GCA	p.A485A		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	485	VWFD.|Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GGGTGCAGGCGCGGGCCCAGC	0.647													A	24582099	A	A	24582099	2	1	200	1	0	0	0	0	0	0	0	1	15405	1074	38	1		1	SUSD2	22	24582099	Silent	SNP	G	TCGA-28-1753-01A-01D-1494-08		24582099	26722467	61	14178											
CYBB	1536	broad.mit.edu	37	chrX	37668843	37668843	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatcactttgctgtgcaccaTgatgaggagaaagatgtgat	11	6	1	5			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chrX:37668843T>C	uc004ddr.2	+	12	1546	c.1485T>C	c.(1483-1485)CAT>CAC	p.H495H	CYBB_uc011mkf.1_Silent_p.H463H|CYBB_uc011mkg.1_Silent_p.H228H	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	495	Cytoplasmic (Potential).				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						CTGTGCACCATGATGAGGAGA	0.398													C	37668843	C	C	37668843	2	2	200	1	0	0	0	0	0	0	0	1	4133	1461	51	4		4	CYBB	23	37668843	Silent	SNP	T	TCGA-28-1753-01A-01D-1494-08		37668843	117601717	62	14179											
GDPD2	54857	broad.mit.edu	37	chrX	69652284	69652284	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagctgctgcagcagatgCgttaccctatctggcttatt	10	12	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chrX:69652284C>T	uc004dyh.2	+	13	1686	c.1435C>T	c.(1435-1437)CGT>TGT	p.R479C	GDPD2_uc010nky.1_3'UTR|GDPD2_uc011mpk.1_Missense_Mutation_p.R530C|GDPD2_uc011mpl.1_Missense_Mutation_p.R400C|GDPD2_uc011mpm.1_Missense_Mutation_p.R400C	NM_017711	NP_060181	Q9HCC8	GDPD2_HUMAN	osteoblast differentiation promoting factor	479	Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			ovary(2)	2	Renal(35;0.156)					GCAGCAGATGCGTTACCCTAT	0.522													T	69652284	T	T	69652284	3	4	200	1	0	0	0	0	1	0	0	0	6324	768	27	1	1638	1	GDPD2	23	69652284	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	31983441	69652284	85618276	63	14180											
NXF3	56000	broad.mit.edu	37	chrX	102337213	102337213	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaggtatccgagaaggtcGtgcacactgggcttctgtcc	14	10	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chrX:102337213G>A	uc004eju.2	-	9	931	c.860C>T	c.(859-861)ACG>ATG	p.T287M	NXF3_uc010noi.1_Missense_Mutation_p.T137M|NXF3_uc011mrw.1_Missense_Mutation_p.T287M|NXF3_uc011mrx.1_Missense_Mutation_p.T198M	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	287						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CGAGAAGGTCGTGCACACTGG	0.542													A	102337213	A	A	102337213	3	1	200	1	0	0	0	0	1	0	0	0	10785	1145	40	1	779	1	NXF3	23	102337213	Missense_Mutation	SNP	G	TCGA-28-1753-01A-01D-1494-08	32684929	102337213	52933347	64	14181											
IRS4	8471	broad.mit.edu	37	chrX	107978476	107978476	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tctgagccagcctcccggctCgagcggcaccaagcccaggt	12	17	1	1			TCGA-28-1753-01A-01D-1494-08	TCGA-28-1753-10B-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	c7143f1e-458c-4129-aa91-61b8e4b90e53	d9fdefb1-7ff6-435d-8319-2c99e82383e6	g.chrX:107978476C>G	uc004eoc.2	-	1	1132	c.1099G>C	c.(1099-1101)GAG>CAG	p.E367Q		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	367						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CCTCCCGGCTCGAGCGGCACC	0.632													G	107978476	G	G	107978476	3	3	200	1	0	0	0	0	1	0	0	0	7842	893	31	5	2678	5	IRS4	23	107978476	Missense_Mutation	SNP	C	TCGA-28-1753-01A-01D-1494-08	5641263	107978476	47292084	65	14182											
CTSS	1520	broad.mit.edu	37	chr1	150727568	150727568	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttgacttatatgtgatatttCtctgccactggctgggaact	9	8	1	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr1:150727568C>T	uc001evn.2	-	4	441	c.308G>A	c.(307-309)AGA>AAA	p.R103K	CTSS_uc010pcj.1_Intron|CTSS_uc001evo.1_Missense_Mutation_p.R103K	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	103					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			TGTGATATTTCTCTGCCACTG	0.353													T	150727568	T	T	150727568	3	4	201	1	0	0	0	0	1	0	0	0	4041	913	32	3	707	3	CTSS	1	150727568	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08		150727568	98523053	1	14183											
ROBLD3	28956	broad.mit.edu	37	chr1	156025122	156025122	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgacgcccgggtcaccgCtgccatagccagtaacatct	9	16	2	1			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr1:156025122C>T	uc001fnb.3	+	2	301	c.137C>T	c.(136-138)GCT>GTT	p.A46V	UBQLN4_uc001fna.2_5'Flank|UBQLN4_uc010pgx.1_5'Flank|ROBLD3_uc010pgy.1_Missense_Mutation_p.A46V	NM_014017	NP_054736	Q9Y2Q5	LTOR2_HUMAN	roadblock domain-containing protein 3 isoform 1	46					cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosomal membrane|Ragulator complex					0						CGGGTCACCGCTGCCATAGCC	0.572													T	156025122	T	T	156025122	3	4	201	1	0	0	0	0	1	0	0	0	13512	797	28	3	143	3	ROBLD3	1	156025122	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08	5297554	156025122	93225499	2	14184											
SPP2	6694	broad.mit.edu	37	chr2	234967547	234967547	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catccgggagactacatgcaGgaaggattctggagaagatc	13	8	1	3			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr2:234967547G>A	uc002vvk.1	+	3	363	c.278G>A	c.(277-279)AGG>AAG	p.R93K	SPP2_uc010fyl.1_Missense_Mutation_p.R13K	NM_006944	NP_008875	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa precursor	93					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity				0		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		ACTACATGCAGGAAGGATTCT	0.453													A	234967547	A	A	234967547	3	1	201	1	0	0	0	0	1	0	0	0	15086	1000	35	3	288	3	SPP2	2	234967547	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08		234967547	8231826	3	14185											
NFXL1	152518	broad.mit.edu	37	chr4	47886362	47886362	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aattgaaattctaatacttaCataggaataggaacttgaca	6	5	1	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr4:47886362C>T	uc010igh.2	-	15	2093	c.1916_splice	c.e15+1	p.M639_splice	NFXL1_uc003gxp.2_Splice_Site_p.M639_splice|NFXL1_uc003gxq.3_Splice_Site|NFXL1_uc010igi.2_Splice_Site_p.M639_splice	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like							integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CTAATACTTACATAGGAATAG	0.368													T	47886362	T	T	47886362	5	4	201	1	0	0	0	0	0	0	1	0	10388	492	17	3	854	3	NFXL1	4	47886362	Splice_Site	SNP	C	TCGA-28-2499-01A-01D-1494-08		47886362	143267914	4	14186											
FRAS1	80144	broad.mit.edu	37	chr4	79402982	79402982	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtaaagattccagttatccGccatggtactgacctctcta	7	11	1	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr4:79402982G>A	uc003hlb.2	+	57	8908	c.8468G>A	c.(8467-8469)CGC>CAC	p.R2823H		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2818	Calx-beta 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CCAGTTATCCGCCATGGTACT	0.468													A	79402982	A	A	79402982	3	1	201	1	0	0	0	0	1	0	0	0	6042	1087	38	1	8769	1	FRAS1	4	79402982	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08	31516620	79402982	111751294	5	14187											
CDH9	1007	broad.mit.edu	37	chr5	26902807	26902807	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tacttgcatccactcttaaaGtatagagcatttgattttca	5	8	2	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr5:26902807G>T	uc003jgs.1	-	7	1200	c.1031C>A	c.(1030-1032)ACT>AAT	p.T344N		NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	344	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CACTCTTAAAGTATAGAGCAT	0.328													T	26902807	T	T	26902807	3	4	201	1	0	0	0	0	1	0	0	0	3117	1029	36	5	1362	5	CDH9	5	26902807	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08		26902807	154012453	6	14188											
PTCD2	79810	broad.mit.edu	37	chr5	71618025	71618025	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatacctacttacagataatGtggtgaaattaaaagaattt	7	4	0	3			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr5:71618025G>A	uc003kcb.2	+	2	164	c.154G>A	c.(154-156)GTG>ATG	p.V52M	MRPS27_uc003kca.3_5'Flank|MRPS27_uc003kbz.3_5'Flank|MRPS27_uc011cse.1_5'Flank|MRPS27_uc010iza.2_5'Flank|PTCD2_uc011csf.1_Translation_Start_Site|PTCD2_uc003kcc.2_Translation_Start_Site|PTCD2_uc011csg.1_Translation_Start_Site|PTCD2_uc011csh.1_Missense_Mutation_p.V52M|PTCD2_uc003kcd.2_RNA	NM_024754	NP_079030	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	52											0		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		TACAGATAATGTGGTGAAATT	0.284													A	71618025	A	A	71618025	3	1	201	1	0	0	0	0	1	0	0	0	12728	1377	48	3	160	3	PTCD2	5	71618025	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08	44715218	71618025	109297235	7	14189											
VDAC1	7416	broad.mit.edu	37	chr5	133326760	133326760	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttctctgtaaacgtcaggCcgtactcagtccatctgtac	7	12	4	0			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr5:133326760C>T	uc003kyp.1	-	4	302	c.203G>A	c.(202-204)GGC>GAC	p.G68D	VDAC1_uc003kyq.1_Missense_Mutation_p.G68D|VDAC1_uc003kyr.1_Missense_Mutation_p.G68D	NM_003374	NP_003365	P21796	VDAC1_HUMAN	voltage-dependent anion channel 1	68					apoptosis|interspecies interaction between organisms	mitochondrial nucleoid|mitochondrial outer membrane|plasma membrane|pore complex	porin activity|protein binding|voltage-gated anion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)		Dihydroxyaluminium(DB01375)	AAACGTCAGGCCGTACTCAGT	0.463													T	133326760	T	T	133326760	3	4	201	1	0	0	0	0	1	0	0	0	17143	739	26	3	672	3	VDAC1	5	133326760	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08	61708735	133326760	47588500	8	14190											
TAP2	6891	broad.mit.edu	37	chr6	32782892	32782892	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccatccacggcctgtctgCtcctctccaagagatccagc	7	19	2	1			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr6:32782892C>T	uc011dqf.1	-	13	2233	c.2111G>A	c.(2110-2112)AGC>AAC	p.S704N	HLA-DOB_uc003oca.2_Missense_Mutation_p.S97N|HLA-DOB_uc011dqg.1_Missense_Mutation_p.S97N	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	Error:Variant_position_missing_in_Q03519_after_alignment					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						GGCCTGTCTGCTCCTCTCCAA	0.592													T	32782892	T	T	32782892	3	4	201	1	0	0	0	0	1	0	0	0	15548	797	28	3		3	TAP2	6	32782892	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08		32782892	138332175	9	14191											
FAM83B	222584	broad.mit.edu	37	chr6	54806575	54806575	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgatcggcgtgtttacagtCgttttgagccgttttgtaag	12	7	0	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr6:54806575C>T	uc003pck.2	+	5	2922	c.2806C>T	c.(2806-2808)CGT>TGT	p.R936C		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	936										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TGTTTACAGTCGTTTTGAGCC	0.438													T	54806575	T	T	54806575	3	4	201	1	0	0	0	0	1	0	0	0	5634	884	31	2	2820	2	FAM83B	6	54806575	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08	22023683	54806575	116308492	10	14192											
DDX56	54606	broad.mit.edu	37	chr7	44611974	44611974	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtaatatcagctccttgagtGcttgtacgtcctcgttaaaa	8	9	1	1			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr7:44611974G>A	uc003tlg.2	-	5	1260	c.617C>T	c.(616-618)GCA>GTA	p.A206V	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Missense_Mutation_p.A142V|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Missense_Mutation_p.A206V|DDX56_uc010kyh.1_RNA	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	206	Helicase ATP-binding.				rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						CTCCTTGAGTGCTTGTACGTC	0.473													A	44611974	A	A	44611974	3	1	201	1	0	0	0	0	1	0	0	0	4374	1319	46	3	1066	3	DDX56	7	44611974	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08		44611974	114526689	11	14193											
MAGI2	9863	broad.mit.edu	37	chr7	77756518	77756518	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctccgggaggaggtacctggGgttgtctgtagtccgacaga	16	9	1	1			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr7:77756518G>T	uc003ugx.2	-	19	3673	c.3419C>A	c.(3418-3420)CCC>CAC	p.P1140H	MAGI2_uc003ugy.2_Missense_Mutation_p.P1126H|MAGI2_uc010ldx.1_Missense_Mutation_p.P733H	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	1140						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGGTACCTGGGGTTGTCTGTA	0.597													T	77756518	T	T	77756518	3	4	201	1	0	0	0	0	1	0	0	0	9191	1232	43	5	964	5	MAGI2	7	77756518	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08	33144544	77756518	81382145	12	14194											
LAMB4	22798	broad.mit.edu	37	chr7	107746315	107746315	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttctgcatagggcgacattCgctagcatggccattgcaaa	10	11	1	0			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr7:107746315C>T	uc010ljo.1	-	8	901	c.817G>A	c.(817-819)GAA>AAA	p.E273K	LAMB4_uc003vey.2_Missense_Mutation_p.E273K	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	273	Laminin EGF-like 1.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						GGGCGACATTCGCTAGCATGG	0.468													T	107746315	T	T	107746315	3	4	201	1	0	0	0	0	1	0	0	0	8613	893	31	2	4576	2	LAMB4	7	107746315	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08	29989797	107746315	51392348	13	14195											
LGI3	203190	broad.mit.edu	37	chr8	22005999	22005999	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttggagtcgccaatgtagcGgctgaggcacaggtagctgt	15	9	0	1			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr8:22005999G>A	uc003xav.2	-	8	1610	c.1321C>T	c.(1321-1323)CGC>TGC	p.R441C	LGI3_uc010ltu.2_Missense_Mutation_p.R417C	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	441	EAR 5.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CCAATGTAGCGGCTGAGGCAC	0.657													A	22005999	A	A	22005999	3	1	201	1	0	0	0	0	1	0	0	0	8753	1116	39	2	329	2	LGI3	8	22005999	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08		22005999	124358023	14	14196											
NRG1	3084	broad.mit.edu	37	chr8	32599524	32599524	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttaccacatttttgccctctAggtgccaacctggattcact	6	13	2	0			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr8:32599524A>G	uc003xiv.2	+	7	1150	c.633_splice	c.e7-2	p.K211_splice	NRG1_uc003xip.2_Intron|NRG1_uc010lvn.2_Intron|NRG1_uc003xis.2_Intron|NRG1_uc011lbf.1_Intron|NRG1_uc010lvo.2_Intron|NRG1_uc003xiu.2_Intron|NRG1_uc003xiw.2_Intron|NRG1_uc003xit.2_Splice_Site_p.K211_splice|NRG1_uc010lvr.2_Intron|NRG1_uc010lvs.2_Intron|NRG1_uc010lvp.2_Intron|NRG1_uc010lvq.2_Intron|NRG1_uc003xix.2_Splice_Site_p.K101_splice|NRG1_uc003xiy.2_Intron|NRG1_uc010lvt.2_Intron|NRG1_uc011lbg.1_Splice_Site_p.K57_splice|NRG1_uc011lbh.1_Intron|NRG1_uc003xiz.1_Splice_Site|NRG1_uc003xja.2_Splice_Site_p.K14_splice	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha						activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TTTGCCCTCTAGGTGCCAACC	0.378													G	32599524	G	G	32599524	5	3	201	1	0	0	0	0	0	0	1	0	10647	434	15	4	2127	4	NRG1	8	32599524	Splice_Site	SNP	A	TCGA-28-2499-01A-01D-1494-08	10593525	32599524	113764498	15	14197											
GML	2765	broad.mit.edu	37	chr8	143928002	143928002	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttgaaagggacatgttacccGatgaagtaactgaggaggag	14	5	0	3			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr8:143928002G>A	uc003yxg.2	+	4	463	c.373G>A	c.(373-375)GAT>AAT	p.D125N		NM_002066	NP_002057	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule	125	UPAR/Ly6.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				central_nervous_system(2)	2	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CATGTTACCCGATGAAGTAAC	0.418													A	143928002	A	A	143928002	3	1	201	1	0	0	0	0	1	0	0	0	6492	1058	37	2	383	2	GML	8	143928002	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08	111328478	143928002	2436020	16	14198											
OR2K2	26248	broad.mit.edu	37	chr9	114090554	114090554	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtacatgggggttttaaggcGtgaatctaggatagtgatca	14	4	2	2	rs117283259	byFrequency	TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr9:114090554G>A	uc011lwp.1	-	1	160	c.160C>T	c.(160-162)CGC>TGC	p.R54C		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	83	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTTTTAAGGCGTGAATCTAGG	0.433													A	114090554	A	A	114090554	3	1	201	1	0	0	0	0	1	0	0	0	11005	1145	40	1	793	1	OR2K2	9	114090554	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08		114090554	27122877	17	14199											
PHRF1	57661	broad.mit.edu	37	chr11	607393	607393	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgccccttgcctctgccgCgtctaagatctcaagcagag	9	15	3	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr11:607393C>T	uc001lqe.2	+	14	2068	c.1937C>T	c.(1936-1938)GCG>GTG	p.A646V	PHRF1_uc010qwc.1_Missense_Mutation_p.A645V|PHRF1_uc010qwd.1_Missense_Mutation_p.A644V|PHRF1_uc010qwe.1_Missense_Mutation_p.A642V|PHRF1_uc009ybz.1_Missense_Mutation_p.A436V|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	646							RNA polymerase binding|zinc ion binding				0						GCCTCTGCCGCGTCTAAGATC	0.587													T	607393	T	T	607393	3	4	201	1	0	0	0	0	1	0	0	0	11861	768	27	1	1984	1	PHRF1	11	607393	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08		607393	134399123	18	14200											
FAT3	120114	broad.mit.edu	37	chr11	92531786	92531786	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gcagagagtcccgttgaagtCaacattgaggtgacagatgt	13	7	1	5			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr11:92531786C>T	uc001pdj.3	+	9	5624	c.5607C>T	c.(5605-5607)GTC>GTT	p.V1869V		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1869	Cadherin 16.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCGTTGAAGTCAACATTGAGG	0.463										TCGA Ovarian(4;0.039)			T	92531786	T	T	92531786	2	4	201	1	0	0	0	0	0	0	0	1	5691	813	29	3		3	FAT3	11	92531786	Silent	SNP	C	TCGA-28-2499-01A-01D-1494-08	91924393	92531786	42474730	19	14201											
TRPC6	7225	broad.mit.edu	37	chr11	101323804	101323804	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caaggagttcatagcggagaCttgagatgtcctgcttaatt	11	7	1	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr11:101323804C>A	uc001pgk.3	-	13	3103	c.2678G>T	c.(2677-2679)AGT>ATT	p.S893I	TRPC6_uc009ywy.2_Missense_Mutation_p.S777I	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	893	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		ATAGCGGAGACTTGAGATGTC	0.388													A	101323804	A	A	101323804	3	1	201	1	0	0	0	0	1	0	0	0	16580	565	20	5	121	5	TRPC6	11	101323804	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08	8792018	101323804	33682712	20	14202											
ANO2	57101	broad.mit.edu	37	chr12	5908717	5908717	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttatagaacactccatagcgCgcccattcttgatatagcag	7	11	1	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr12:5908717C>T	uc001qnm.2	-	10	1071	c.999G>A	c.(997-999)GCG>GCA	p.A333A		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	338	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CTCCATAGCGCGCCCATTCTT	0.418													T	5908717	T	T	5908717	2	4	201	1	0	0	0	0	0	0	0	1	697	755	27	1		1	ANO2	12	5908717	Silent	SNP	C	TCGA-28-2499-01A-01D-1494-08		5908717	127943178	21	14203											
LECT1	11061	broad.mit.edu	37	chr13	53307443	53307443	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cccagcgtctatttccattgAcccatcttgtaatttcccat	4	14	2	1			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr13:53307443A>G	uc001vhf.2	-	3	376	c.265T>C	c.(265-267)TCA>CCA	p.S89P	LECT1_uc001vhg.2_Missense_Mutation_p.S89P|LECT1_uc001vhh.2_Missense_Mutation_p.S116P	NM_007015	NP_008946	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1 isoform 1	89					cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		ATTTCCATTGACCCATCTTGT	0.363													G	53307443	G	G	53307443	3	3	201	1	0	0	0	0	1	0	0	0	8712	275	10	4	759	4	LECT1	13	53307443	Missense_Mutation	SNP	A	TCGA-28-2499-01A-01D-1494-08		53307443	61862435	22	14204											
TFDP1	7027	broad.mit.edu	37	chr13	114286001	114286001	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggtaggaagcccacacaccCccagcactcactttgcctct	7	17	2	0			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr13:114286001C>A	uc001vtw.2	+	5	462	c.250C>A	c.(250-252)CCC>ACC	p.P84T	TFDP1_uc010tkd.1_Intron|TFDP1_uc010tke.1_Intron|TFDP1_uc001vty.3_Missense_Mutation_p.P84T|TFDP1_uc001vtx.2_5'Flank|TFDP1_uc010agx.2_Missense_Mutation_p.P84T	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	84					cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			CCCACACACCCCCAGCACTCA	0.557										TSP Lung(29;0.18)			A	114286001	A	A	114286001	3	1	201	1	0	0	0	0	1	0	0	0	15794	623	22	5	264	5	TFDP1	13	114286001	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08	60978558	114286001	883877	23	14205											
WDR72	256764	broad.mit.edu	37	chr15	53908374	53908374	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagaagaatatgaaagccaaCgttactccattttgtcttca	6	8	2	3			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr15:53908374C>T	uc002acj.2	-	15	2071	c.2029G>A	c.(2029-2031)GTT>ATT	p.V677I	WDR72_uc010bfi.1_Missense_Mutation_p.V677I	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	677										lung(1)|skin(1)	2				all cancers(107;0.0511)		TGAAAGCCAACGTTACTCCAT	0.378													T	53908374	T	T	53908374	3	4	201	1	0	0	0	0	1	0	0	0	17319	536	19	1	1303	1	WDR72	15	53908374	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08		53908374	48623018	24	14206											
TLN2	83660	broad.mit.edu	37	chr15	63063321	63063321	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatgcagccaaagaaggtggCggaaaccccaaggtatggtc	13	9	0	1			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr15:63063321C>T	uc002alb.3	+	39	5355	c.5355C>T	c.(5353-5355)GGC>GGT	p.G1785G	TLN2_uc002alc.3_Silent_p.G178G|TLN2_uc002ald.2_Silent_p.G178G	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1785					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						AAGAAGGTGGCGGAAACCCCA	0.507													T	63063321	T	T	63063321	2	4	201	1	0	0	0	0	0	0	0	1	15945	755	27	1		1	TLN2	15	63063321	Silent	SNP	C	TCGA-28-2499-01A-01D-1494-08	9154947	63063321	39468071	25	14207											
AXIN1	8312	broad.mit.edu	37	chr16	339566	339566	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacaacgatgctgtcacacGgctgggcactcccgccgccc	10	19	1	0			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr16:339566G>A	uc002cgp.1	-	10	2513	c.2336C>T	c.(2335-2337)CCG>CTG	p.P779L	AXIN1_uc002cgq.1_Missense_Mutation_p.P743L	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	779	Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GCTGTCACACGGCTGGGCACT	0.637													A	339566	A	A	339566	3	1	201	1	0	0	0	0	1	0	0	0	1236	1116	39	2	260	2	AXIN1	16	339566	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08		339566	90015187	26	14208											
TEKT5	146279	broad.mit.edu	37	chr16	10788283	10788283	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctcagctctgacttccagaAgccaatgtccgacagcctct	8	15	3	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr16:10788283A>G	uc002czz.1	-	1	520	c.448T>C	c.(448-450)TTC>CTC	p.F150L		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	150	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						GACTTCCAGAAGCCAATGTCC	0.597													G	10788283	G	G	10788283	3	3	201	1	0	0	0	0	1	0	0	0	15753	72	3	4	1037	4	TEKT5	16	10788283	Missense_Mutation	SNP	A	TCGA-28-2499-01A-01D-1494-08	10448717	10788283	79566470	27	14209											
PKD1L2	114780	broad.mit.edu	37	chr16	81219137	81219137	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagggcgcagacacgtagaGgcactgctctgccctgttct	12	14	2	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr16:81219137G>A	uc002fgh.1	-	11	1957	c.1957C>T	c.(1957-1959)CTC>TTC	p.L653F	PKD1L2_uc002fgj.2_Missense_Mutation_p.L653F	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	653	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GACACGTAGAGGCACTGCTCT	0.567													A	81219137	A	A	81219137	3	1	201	1	0	0	0	0	1	0	0	0	11965	1000	35	3	5623	3	PKD1L2	16	81219137	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08	70430854	81219137	9135616	28	14210											
SLC13A2	9058	broad.mit.edu	37	chr17	26822743	26822743	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgccagctccagccattgCcatcatcctctccctcctgg	7	18	2	0			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr17:26822743C>T	uc002hbh.2	+	10	1446	c.1379C>T	c.(1378-1380)GCC>GTC	p.A460V	SLC13A2_uc010wam.1_Missense_Mutation_p.A416V|SLC13A2_uc010wan.1_Missense_Mutation_p.A509V|SLC13A2_uc010wao.1_Missense_Mutation_p.A417V|SLC13A2_uc002hbi.2_Missense_Mutation_p.A389V	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	460	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CCAGCCATTGCCATCATCCTC	0.607													T	26822743	T	T	26822743	3	4	201	1	0	0	0	0	1	0	0	0	14392	739	26	3	1564	3	SLC13A2	17	26822743	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08		26822743	54372467	29	14211											
GPS1	2873	broad.mit.edu	37	chr17	80011213	80011213	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acccgcagaatgcacctgacGtcaactacgtggtggagaac	11	12	1	3	rs146475501		TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr17:80011213G>A	uc002kdl.1	+	2	142	c.97G>A	c.(97-99)GTC>ATC	p.V33I	RFNG_uc002kdh.2_5'Flank|RFNG_uc002kdj.2_5'Flank|GPS1_uc002kdk.1_Missense_Mutation_p.V73I|GPS1_uc010dij.1_Missense_Mutation_p.V73I|GPS1_uc002kdm.1_Missense_Mutation_p.V17I|GPS1_uc002kdn.1_Missense_Mutation_p.V33I|GPS1_uc002kdo.1_Missense_Mutation_p.V33I|GPS1_uc010wvh.1_Missense_Mutation_p.V25I	NM_004127	NP_004118	Q13098	CSN1_HUMAN	G protein pathway suppressor 1 isoform 2	33					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			TGCACCTGACGTCAACTACGT	0.667													A	80011213	A	A	80011213	3	1	201	1	0	0	0	0	1	0	0	0	6732	1145	40	1	260	1	GPS1	17	80011213	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08	53188470	80011213	1183997	30	14212											
TSPAN16	26526	broad.mit.edu	37	chr19	11408879	11408879	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtggaggggcctctctgaCgaatgtcctcgggctgtcct	14	11	1	1	rs138340787		TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr19:11408879C>T	uc002mqv.1	+	2	281	c.131C>T	c.(130-132)ACG>ATG	p.T44M	TSPAN16_uc002mqu.1_RNA	NM_012466	NP_036598	Q9UKR8	TSN16_HUMAN	transmembrane 4 superfamily member 16	44	Helical; (Potential).					integral to membrane				skin(1)	1						GCCTCTCTGACGAATGTCCTC	0.532													T	11408879	T	T	11408879	3	4	201	1	0	0	0	0	1	0	0	0	16637	536	19	1	137	1	TSPAN16	19	11408879	Missense_Mutation	SNP	C	TCGA-28-2499-01A-01D-1494-08		11408879	47720104	31	14213											
CALR	811	broad.mit.edu	37	chr19	13050871	13050871	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgcttcacacctaggtccCgacatctgtggccctggcac	9	16	3	0			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr19:13050871C>T	uc002mvu.2	+	4	482	c.402C>T	c.(400-402)CCC>CCT	p.P134P		NM_004343	NP_004334	P27797	CALR_HUMAN	calreticulin precursor	134	N-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCTAGGTCCCGACATCTGTG	0.502													T	13050871	T	T	13050871	2	4	201	1	0	0	0	0	0	0	0	1	2592	639	23	2		2	CALR	19	13050871	Silent	SNP	C	TCGA-28-2499-01A-01D-1494-08	1641992	13050871	46078112	32	14214											
PGLYRP2	114770	broad.mit.edu	37	chr19	15586693	15586693	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggttaacagagatgccttgGggtccaaaagcgtaaaggtc	13	7	0	1			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr19:15586693G>A	uc002nbf.3	-	2	921	c.788C>T	c.(787-789)CCC>CTC	p.P263L	PGLYRP2_uc002nbg.3_Missense_Mutation_p.P263L	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	263					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						AGATGCCTTGGGGTCCAAAAG	0.617													A	15586693	A	A	15586693	3	1	201	1	0	0	0	0	1	0	0	0	11794	1232	43	3	958	3	PGLYRP2	19	15586693	Missense_Mutation	SNP	G	TCGA-28-2499-01A-01D-1494-08	2535822	15586693	43542290	33	14215											
ZNF337	26152	broad.mit.edu	37	chr20	25655873	25655873	+	Frame_Shift_Del	DEL	G	-	-													tacactcctggcaaacaaaaGgcttctcctttgagtgtatc							TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr20:25655873delG	uc002wva.2	-	4	2573	c.2051delC	c.(2050-2052)CCTfs	p.P684fs	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Frame_Shift_Del_p.P652fs|ZNF337_uc002wvb.2_Frame_Shift_Del_p.P684fs|ZNF337_uc002wvc.2_Frame_Shift_Del_p.P684fs	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	684					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCAAACAAAAGGCTTCTCCTT	0.502													-	25655873	-	-	25655873	7	5	201	1	0	1	0	1	0	0	0	0	17850	1000	35	0	208	0	ZNF337	20	25655873	Frame_Shift_Del	DEL	G	TCGA-28-2499-01A-01D-1494-08		25655873	37369647	34	14216											
PABPC1L	80336	broad.mit.edu	37	chr20	43559261	43559261	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agaggagcggaaggccatctTgaccaaccagtacatgcagc	12	11	1	2			TCGA-28-2499-01A-01D-1494-08	TCGA-28-2499-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	28583f40-c3fc-4213-91c1-99d7d536551e	bfeda2fa-2ff8-40d0-9c7d-9edd34d95451	g.chr20:43559261T>A	uc010ggv.1	+	8	1215	c.1133T>A	c.(1132-1134)TTG>TAG	p.L378*	PABPC1L_uc010zwq.1_RNA|PABPC1L_uc002xmv.2_RNA|PABPC1L_uc002xmw.2_5'Flank|PABPC1L_uc002xmx.2_5'Flank	NM_001124756	NP_001118228	Q4VXU2	PAP1L_HUMAN	poly(A)-binding protein, cytoplasmic 1-like	378							nucleotide binding|RNA binding			ovary(1)	1						AAGGCCATCTTGACCAACCAG	0.627													A	43559261	A	A	43559261	4	1	201	1	0	0	0	0	0	1	0	0	11364	1821	63	5	1163	5	PABPC1L	20	43559261	Nonsense_Mutation	SNP	T	TCGA-28-2499-01A-01D-1494-08	17903388	43559261	19466259	35	14217											
SCNN1D	6339	broad.mit.edu	37	chr1	1222931	1222931	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccacctacggcagctgctacAcggtcgatggcgtctggaca	12	14	1	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:1222931A>G	uc001adu.1	+	9	1486	c.862A>G	c.(862-864)ACG>GCG	p.T288A	SCNN1D_uc001adt.1_Missense_Mutation_p.T452A|SCNN1D_uc001adw.2_Missense_Mutation_p.T354A|SCNN1D_uc001adx.2_Silent_p.T51T|SCNN1D_uc001adv.2_Missense_Mutation_p.T288A	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CAGCTGCTACACGGTCGATGG	0.677													G	1222931	G	G	1222931	3	3	202	1	0	0	0	0	1	0	0	0	13929	159	6	4	1086	4	SCNN1D	1	1222931	Missense_Mutation	SNP	A	TCGA-28-2501-01A-01D-1696-08		1222931	248027690	1	14218											
ACTL8	81569	broad.mit.edu	37	chr1	18152553	18152553	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcagatgaacaagtgctacGtgccgcagaatctgggggag	14	9	2	3			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:18152553G>A	uc001bat.2	+	3	856	c.640G>A	c.(640-642)GTG>ATG	p.V214M		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	214						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CAAGTGCTACGTGCCGCAGAA	0.567											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	18152553	A	A	18152553	3	1	202	1	0	0	0	0	1	0	0	0	202	1145	40	1	646	1	ACTL8	1	18152553	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	16929622	18152553	231098068	2	14219											
SCMH1	22955	broad.mit.edu	37	chr1	41514522	41514522	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaccttcttcttatctaaGtgggggcctgtgctgccatt	11	10	3	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:41514522G>A	uc001cgo.2	-	11	1427	c.1116C>T	c.(1114-1116)CAC>CAT	p.H372H	SCMH1_uc010ojr.1_Silent_p.H214H|SCMH1_uc001cgp.2_Silent_p.H311H|SCMH1_uc001cgr.2_Silent_p.H311H|SCMH1_uc001cgs.2_Silent_p.H382H|SCMH1_uc001cgt.2_Silent_p.H311H|SCMH1_uc001cgq.2_Silent_p.H325H|SCMH1_uc010ojs.1_RNA	NM_001031694	NP_001026864	Q96GD3	SCMH1_HUMAN	sex comb on midleg 1 isoform 1	372					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				TCTTATCTAAGTGGGGGCCTG	0.493													A	41514522	A	A	41514522	2	1	202	1	0	0	0	0	0	0	0	1	13908	1020	36	3		3	SCMH1	1	41514522	Silent	SNP	G	TCGA-28-2501-01A-01D-1696-08	23361969	41514522	207736099	3	14220											
CPT2	1376	broad.mit.edu	37	chr1	53666396	53666396	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctttctccccaggctgcCtattcccaaacttgaagaca	6	15	1	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:53666396C>T	uc001cvb.3	+	2	673	c.158C>T	c.(157-159)CCT>CTT	p.P53L		NM_000098	NP_000089	P23786	CPT2_HUMAN	carnitine O-palmitoyltransferase precursor	53	Mitochondrial matrix (By similarity).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity				0					L-Carnitine(DB00583)|Perhexiline(DB01074)	CCCAGGCTGCCTATTCCCAAA	0.433													T	53666396	T	T	53666396	3	4	202	1	0	0	0	0	1	0	0	0	3834	681	24	3	164	3	CPT2	1	53666396	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	12151874	53666396	195584225	4	14221											
PKLR	5313	broad.mit.edu	37	chr1	155264053	155264053	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacagacaacaggcttgccCgccaagttgcagcgcccaat	10	15	0	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:155264053C>T	uc001fkb.3	-	7	1128	c.1089G>A	c.(1087-1089)GCG>GCA	p.A363A	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Silent_p.A332A	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	363					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CAGGCTTGCCCGCCAAGTTGC	0.577													T	155264053	T	T	155264053	2	4	202	1	0	0	0	0	0	0	0	1	11976	639	23	2		2	PKLR	1	155264053	Silent	SNP	C	TCGA-28-2501-01A-01D-1696-08	101597657	155264053	93986568	5	14222											
MPZL1	9019	broad.mit.edu	37	chr1	167757139	167757139	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcagagtctgtggtgtatgCggatatccgaaagaattaag	13	5	2	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:167757139C>T	uc001geo.2	+	6	993	c.791C>T	c.(790-792)GCG>GTG	p.A264V	MPZL1_uc001gep.2_3'UTR|MPZL1_uc001geq.2_Missense_Mutation_p.A114V|MPZL1_uc009wvh.2_RNA	NM_003953	NP_003944	O95297	MPZL1_HUMAN	myelin protein zero-like 1 isoform a	264	ITIM motif 2.|Cytoplasmic (Potential).				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			ovary(2)	2	all_hematologic(923;0.215)					GTGGTGTATGCGGATATCCGA	0.448													T	167757139	T	T	167757139	3	4	202	1	0	0	0	0	1	0	0	0	9749	768	27	1	813	1	MPZL1	1	167757139	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	12493086	167757139	81493482	6	14223											
HMCN1	83872	broad.mit.edu	37	chr1	185956672	185956672	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	caaaccgtctgtcatctggtCcaaggtaaatgatacatcta	7	10	4	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:185956672C>G	uc001grq.1	+	20	3273	c.3044C>G	c.(3043-3045)TCC>TGC	p.S1015C	HMCN1_uc001grr.1_Missense_Mutation_p.S356C	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1015	Ig-like C2-type 7.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTCATCTGGTCCAAGGTAAAT	0.458													G	185956672	G	G	185956672	3	3	202	1	0	0	0	0	1	0	0	0	7220	855	30	5	3122	5	HMCN1	1	185956672	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	18199533	185956672	63293949	7	14224											
RBBP5	5929	broad.mit.edu	37	chr1	205065884	205065884	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gtggctgggacccatctgctGaggactgcctcttcttctct	11	13	4	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:205065884G>A	uc001hbu.1	-	12	1452	c.1322C>T	c.(1321-1323)TCA>TTA	p.S441L	RBBP5_uc010prd.1_Missense_Mutation_p.S476L|RBBP5_uc001hbv.1_Missense_Mutation_p.S441L|RBBP5_uc010pre.1_Missense_Mutation_p.S308L	NM_005057	NP_005048	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	441					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			lung(1)	1	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			CCCATCTGCTGAGGACTGCCT	0.493													A	205065884	A	A	205065884	3	1	202	1	0	0	0	0	1	0	0	0	13102	1294	45	3	306	3	RBBP5	1	205065884	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	19109212	205065884	44184737	8	14225											
KCNK1	3775	broad.mit.edu	37	chr1	233802400	233802400	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttctgcatcatctactccGtcattggcattcccttcacc	4	17	5	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:233802400G>A	uc010pxo.1	+	2	583	c.415G>A	c.(415-417)GTC>ATC	p.V139I	KCNK1_uc001hvw.2_RNA|KCNK1_uc001hvx.2_RNA	NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	139	Helical; (Potential).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	CATCTACTCCGTCATTGGCAT	0.582													A	233802400	A	A	233802400	3	1	202	1	0	0	0	0	1	0	0	0	8058	1145	40	1	421	1	KCNK1	1	233802400	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	28736516	233802400	15448221	9	14226											
RYR2	6262	broad.mit.edu	37	chr1	237947838	237947838	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaaagtaaaaaagatgaccGtgaaggacatggtcacggcc	11	7	1	3			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:237947838G>A	uc001hyl.1	+	90	12946	c.12826G>A	c.(12826-12828)GTG>ATG	p.V4276M	RYR2_uc010pya.1_Missense_Mutation_p.V691M	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4276					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAAGATGACCGTGAAGGACAT	0.468													A	237947838	A	A	237947838	3	1	202	1	0	0	0	0	1	0	0	0	13769	1145	40	1	13184	1	RYR2	1	237947838	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	4145438	237947838	11302783	10	14227											
NLRP3	114548	broad.mit.edu	37	chr1	247587842	247587842	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacttgctggaccatcctcGgcatgtggagatcctgggtt	13	11	0	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr1:247587842G>A	uc001icr.2	+	5	1235	c.1097G>A	c.(1096-1098)CGG>CAG	p.R366Q	NLRP3_uc001ics.2_Missense_Mutation_p.R366Q|NLRP3_uc001icu.2_Missense_Mutation_p.R366Q|NLRP3_uc001icw.2_Missense_Mutation_p.R366Q|NLRP3_uc001icv.2_Missense_Mutation_p.R366Q|NLRP3_uc010pyw.1_Missense_Mutation_p.R364Q|NLRP3_uc001ict.1_Missense_Mutation_p.R364Q	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	366	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GACCATCCTCGGCATGTGGAG	0.547													A	247587842	A	A	247587842	3	1	202	1	0	0	0	0	1	0	0	0	10478	1116	39	2	1107	2	NLRP3	1	247587842	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	9640004	247587842	1662779	11	14228											
SLC5A7	60482	broad.mit.edu	37	chr2	108604723	108604723	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagtggcagcgcagaagagCgcagcgaagccatcatagtt	13	10	1	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr2:108604723C>T	uc002tdv.2	+	2	388	c.112C>T	c.(112-114)CGC>TGC	p.R38C	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.R38C|SLC5A7_uc010ywn.1_Intron	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	38	Extracellular (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CGCAGAAGAGCGCAGCGAAGC	0.502													T	108604723	T	T	108604723	3	4	202	1	0	0	0	0	1	0	0	0	14670	768	27	1	114	1	SLC5A7	2	108604723	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08		108604723	134594650	12	14229											
MYO7B	4648	broad.mit.edu	37	chr2	128366343	128366343	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgctctccctgccaagaagCgcagatccatctacgacacc	8	17	2	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr2:128366343C>T	uc002top.2	+	22	2757	c.2704C>T	c.(2704-2706)CGC>TGC	p.R902C		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	902						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGCCAAGAAGCGCAGATCCAT	0.652													T	128366343	T	T	128366343	3	4	202	1	0	0	0	0	1	0	0	0	10083	768	27	1	2786	1	MYO7B	2	128366343	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	19761620	128366343	114833030	13	14230											
POTEE	445582	broad.mit.edu	37	chr2	131976471	131976471	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatgctcagggacactgacGtgaacaagaaggacaagcaa	11	9	2	3			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr2:131976471G>A	uc002tsn.2	+	1	548	c.496G>A	c.(496-498)GTG>ATG	p.V166M	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Translation_Start_Site|POTEE_uc002tsl.2_Translation_Start_Site	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	166							ATP binding				0						GGACACTGACGTGAACAAGAA	0.592													A	131976471	A	A	131976471	3	1	202	1	0	0	0	0	1	0	0	0	12264	1145	40	1	498	1	POTEE	2	131976471	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	3610128	131976471	111222902	14	14231											
TTN	7273	broad.mit.edu	37	chr2	179542438	179542438	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcaggtacatattcttcttCgggaggaacttcctcttcct	7	12	4	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr2:179542438C>T	uc010zfg.1	-	143	30693	c.30469G>A	c.(30469-30471)GAA>AAA	p.E10157K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E6818K|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11084							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTCTTCTTCGGGAGGAACT	0.453													T	179542438	T	T	179542438	3	4	202	1	0	0	0	0	1	0	0	0	16732	893	31	2	70196	2	TTN	2	179542438	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	47565967	179542438	63656935	15	14232											
TTN	7273	broad.mit.edu	37	chr2	179639038	179639038	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgtgaggttctgacgtccaCgacgagatgtaattgtatat	11	8	1	3			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr2:179639038C>T	uc010zfg.1	-	30	7177	c.6953G>A	c.(6952-6954)CGT>CAT	p.R2318H	TTN_uc010zfh.1_Missense_Mutation_p.R2272H|TTN_uc010zfi.1_Missense_Mutation_p.R2272H|TTN_uc010zfj.1_Missense_Mutation_p.R2272H|TTN_uc002unb.2_Missense_Mutation_p.R2318H|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2318							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGACGTCCACGACGAGATGT	0.403													T	179639038	T	T	179639038	3	4	202	1	0	0	0	0	1	0	0	0	16732	536	19	1	104367	1	TTN	2	179639038	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	96600	179639038	63560335	16	14233											
DOCK10	55619	broad.mit.edu	37	chr2	225670162	225670162	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcttctcactgctcttctcaTtggtacttggattggagtca	8	10	5	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr2:225670162T>C	uc010fwz.1	-	35	4138	c.3899A>G	c.(3898-3900)AAT>AGT	p.N1300S	DOCK10_uc002vob.2_Missense_Mutation_p.N1294S|DOCK10_uc002voa.2_5'UTR|DOCK10_uc002voc.2_Missense_Mutation_p.N154S	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1300							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GCTCTTCTCATTGGTACTTGG	0.423													C	225670162	C	C	225670162	3	2	202	1	0	0	0	0	1	0	0	0	4685	1493	52	4	2749	4	DOCK10	2	225670162	Missense_Mutation	SNP	T	TCGA-28-2501-01A-01D-1696-08	46031124	225670162	17529211	17	14234											
UBA7	7318	broad.mit.edu	37	chr3	49849871	49849871	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatagaccggggatcacagtCgttgagctcaaccattccct	10	12	2	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr3:49849871C>T	uc003cxr.2	-	6	835	c.664G>A	c.(664-666)GAC>AAC	p.D222N		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	222	2 approximate repeats.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGATCACAGTCGTTGAGCTCA	0.567													T	49849871	T	T	49849871	3	4	202	1	0	0	0	0	1	0	0	0	16830	884	31	2	2450	2	UBA7	3	49849871	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08		49849871	148172559	18	14235											
EPHB1	2047	broad.mit.edu	37	chr3	134851749	134851749	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tttgtgcccaggcagctgggCctgacggagtgccgcgtctc	15	13	1	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr3:134851749C>A	uc003eqt.2	+	5	1375	c.1155C>A	c.(1153-1155)GGC>GGA	p.G385G	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	385	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GGCAGCTGGGCCTGACGGAGT	0.597													A	134851749	A	A	134851749	2	1	202	1	0	0	0	0	0	0	0	1	5174	726	26	5		5	EPHB1	3	134851749	Silent	SNP	C	TCGA-28-2501-01A-01D-1696-08	85001878	134851749	63170681	19	14236											
HTR3E	285242	broad.mit.edu	37	chr3	183824082	183824082	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggagatgctgtcccactgcGccccagaaggaaaataaggg	14	10	0	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr3:183824082G>A	uc010hxq.2	+	8	1558	c.1092G>A	c.(1090-1092)GCG>GCA	p.A364A	HTR3E_uc003fml.3_Silent_p.A349A|HTR3E_uc003fmm.2_Silent_p.A379A|HTR3E_uc010hxr.2_Silent_p.A390A|HTR3E_uc003fmn.2_Silent_p.A364A	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	364	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity	p.S364S(1)		ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GTCCCACTGCGCCCCAGAAGG	0.557													A	183824082	A	A	183824082	2	1	202	1	0	0	0	0	0	0	0	1	7448	1074	38	1		1	HTR3E	3	183824082	Silent	SNP	G	TCGA-28-2501-01A-01D-1696-08	48972333	183824082	14198348	20	14237											
DGKG	1608	broad.mit.edu	37	chr3	185975697	185975697	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaccacaggccaaaacacGgaagtctggagtatcacgga	10	12	2	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr3:185975697G>A	uc003fqa.2	-	17	1993	c.1456C>T	c.(1456-1458)CGT>TGT	p.R486C	DGKG_uc003fqb.2_Missense_Mutation_p.R447C|DGKG_uc003fqc.2_Missense_Mutation_p.R461C|DGKG_uc011brx.1_Missense_Mutation_p.R427C	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	486	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	GCCAAAACACGGAAGTCTGGA	0.463													A	185975697	A	A	185975697	3	1	202	1	0	0	0	0	1	0	0	0	4469	1116	39	2	955	2	DGKG	3	185975697	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	2151615	185975697	12046733	21	14238											
BDH1	622	broad.mit.edu	37	chr3	197238913	197238913	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcatcgatgacaggggaCgtgtctgtggagccactgct	14	10	1	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr3:197238913C>T	uc003fxr.2	-	8	1287	c.885G>A	c.(883-885)ACG>ACA	p.T295T	BDH1_uc003fxs.2_Silent_p.T295T|BDH1_uc003fxt.2_Silent_p.T208T|BDH1_uc003fxu.2_Silent_p.T295T	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	295					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	TGACAGGGGACGTGTCTGTGG	0.577													T	197238913	T	T	197238913	2	4	202	1	0	0	0	0	0	0	0	1	1390	523	19	1		1	BDH1	3	197238913	Silent	SNP	C	TCGA-28-2501-01A-01D-1696-08	11263216	197238913	783517	22	14239											
AMBN	258	broad.mit.edu	37	chr4	71472354	71472354	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaagcaaccatggataccacGatggccccaaactctctgca	8	14	1	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr4:71472354G>A	uc003hfl.2	+	13	1326	c.1251G>A	c.(1249-1251)ACG>ACA	p.T417T		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	417					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			TGGATACCACGATGGCCCCAA	0.512													A	71472354	A	A	71472354	2	1	202	1	0	0	0	0	0	0	0	1	563	1045	37	2		2	AMBN	4	71472354	Silent	SNP	G	TCGA-28-2501-01A-01D-1696-08		71472354	119681922	23	14240											
IRX1	79192	broad.mit.edu	37	chr5	3600344	3600344	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcactcaatggagacaagGcctcggtccgcagcagcccc	13	15	1	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr5:3600344G>A	uc003jde.2	+	2	1334	c.1282G>A	c.(1282-1284)GCC>ACC	p.A428T		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	428						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						TGGAGACAAGGCCTCGGTCCG	0.697													A	3600344	A	A	3600344	3	1	202	1	0	0	0	0	1	0	0	0	7843	1203	42	3	1288	3	IRX1	5	3600344	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08		3600344	177314916	24	14241											
CMYA5	202333	broad.mit.edu	37	chr5	79026546	79026546	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccctacatctgagagctctcTctcaccatccacaactgaga	5	16	3	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr5:79026546T>C	uc003kgc.2	+	2	2030	c.1958T>C	c.(1957-1959)CTC>CCC	p.L653P		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	653						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAGAGCTCTCTCTCACCATCC	0.458													C	79026546	C	C	79026546	3	2	202	1	0	0	0	0	1	0	0	0	3590	1551	54	4	1964	4	CMYA5	5	79026546	Missense_Mutation	SNP	T	TCGA-28-2501-01A-01D-1696-08	75426202	79026546	101888714	25	14242											
ABLIM3	22885	broad.mit.edu	37	chr5	148617052	148617052	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttaattacaaagacctggcGgctctccccaaggttaagtc	8	12	1	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr5:148617052G>T	uc003lpy.2	+	11	1181	c.930G>T	c.(928-930)GCG>GCT	p.A310A	ABLIM3_uc003lpz.1_Silent_p.A310A|ABLIM3_uc003lqa.1_Intron|ABLIM3_uc003lqb.2_Intron|ABLIM3_uc003lqc.1_Silent_p.A310A|ABLIM3_uc003lqd.1_Intron|ABLIM3_uc003lqf.2_Intron|ABLIM3_uc003lqe.1_Intron	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	310					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGACCTGGCGGCTCTCCCCA	0.468													T	148617052	T	T	148617052	2	4	202	1	0	0	0	0	0	0	0	1	96	1103	39	5		5	ABLIM3	5	148617052	Silent	SNP	G	TCGA-28-2501-01A-01D-1696-08	69590506	148617052	32298208	26	14243											
SLIT3	6586	broad.mit.edu	37	chr5	168620553	168620553	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcttattcttgttcaggcGcctaaagaggaaagagaatg	11	7	2	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr5:168620553G>A	uc003mab.2	-	4	763	c.343C>T	c.(343-345)CGC>TGC	p.R115C	SLIT3_uc010jjg.2_Missense_Mutation_p.R115C|SLIT3_uc010jji.2_Missense_Mutation_p.R115C	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	115	LRR 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGTTCAGGCGCCTAAAGAGG	0.408													A	168620553	A	A	168620553	3	1	202	1	0	0	0	0	1	0	0	0	14741	1101	38	1	4360	1	SLIT3	5	168620553	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	20003501	168620553	12294707	27	14244											
MDC1	9656	broad.mit.edu	37	chr6	30682871	30682871	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagccgccctactggctccaCgttacacctcaaggattcac	7	16	2	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr6:30682871C>T	uc003nrg.3	-	2	522	c.82G>A	c.(82-84)GTG>ATG	p.V28M	MDC1_uc003nrf.3_5'Flank|MDC1_uc011dmp.1_Translation_Start_Site|MDC1_uc003nrh.1_Translation_Start_Site|MDC1_uc003nri.2_Missense_Mutation_p.V28M	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	28	Interaction with the MRN complex.|Interaction with CHEK2.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						ACTGGCTCCACGTTACACCTC	0.458								Other_conserved_DNA_damage_response_genes					T	30682871	T	T	30682871	3	4	202	1	0	0	0	0	1	0	0	0	9403	536	19	1	6243	1	MDC1	6	30682871	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08		30682871	140432196	28	14245											
IER3	8870	broad.mit.edu	37	chr6	30711832	30711832	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggggtgggcgccagggatgCggcgttaggggcgtcctctg	21	9	1	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr6:30711832C>T	uc003nrn.2	-	2	384	c.352G>A	c.(352-354)GCA>ACA	p.A118T	FLOT1_uc003nrm.2_5'Flank|FLOT1_uc011dmr.1_5'Flank	NM_003897	NP_003888	P46695	IEX1_HUMAN	immediate early response 3	118	Extracellular (Potential).				anatomical structure morphogenesis|anti-apoptosis|apoptosis	integral to membrane	protein binding				0						GCCAGGGATGCGGCGTTAGGG	0.627													T	30711832	T	T	30711832	3	4	202	1	0	0	0	0	1	0	0	0	7506	768	27	1	122	1	IER3	6	30711832	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	28961	30711832	140403235	29	14246											
BBS9	27241	broad.mit.edu	37	chr7	33397475	33397475	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttttattttaggcattccgCgagttatccaatgtaaattt	6	7	0	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr7:33397475C>T	uc003tdn.1	+	16	2074	c.1561C>T	c.(1561-1563)CGA>TGA	p.R521*	BBS9_uc003tdo.1_Nonsense_Mutation_p.R486*|BBS9_uc003tdp.1_Nonsense_Mutation_p.R516*|BBS9_uc003tdq.1_Nonsense_Mutation_p.R481*|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Nonsense_Mutation_p.R45*|BBS9_uc003tds.1_5'UTR|BBS9_uc011kao.1_Nonsense_Mutation_p.R399*	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	521					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			AGGCATTCCGCGAGTTATCCA	0.323									Bardet-Biedl_syndrome				T	33397475	T	T	33397475	4	4	202	1	0	0	0	0	0	1	0	0	1342	760	27	1	1619	1	BBS9	7	33397475	Nonsense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08		33397475	125741188	30	14247											
PCLO	27445	broad.mit.edu	37	chr7	82584801	82584801	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattactaggtggtgtctttGgcctttcccttcttctctga	9	10	3	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr7:82584801G>A	uc003uhx.2	-	5	5757	c.5468C>T	c.(5467-5469)CCA>CTA	p.P1823L	PCLO_uc003uhv.2_Missense_Mutation_p.P1823L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1754					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGGTGTCTTTGGCCTTTCCCT	0.423													A	82584801	A	A	82584801	3	1	202	1	0	0	0	0	1	0	0	0	11583	1348	47	3	10061	3	PCLO	7	82584801	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	49187326	82584801	76553862	31	14248											
DMTF1	9988	broad.mit.edu	37	chr7	86815172	86815172	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaacttgatgtagctgatgaAaatgacattaactgggatct	10	5	1	4			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr7:86815172A>G	uc003uih.2	+	12	1403	c.1077A>G	c.(1075-1077)GAA>GAG	p.E359E	DMTF1_uc003uii.2_Silent_p.E93E|DMTF1_uc003uij.2_Silent_p.E93E|DMTF1_uc011khb.1_Silent_p.E271E|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Silent_p.E359E|DMTF1_uc003uin.2_Silent_p.E93E	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	359	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for DNA-binding (By similarity).|Myb-like 2.				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					TAGCTGATGAAAATGACATTA	0.398													G	86815172	G	G	86815172	2	3	202	1	0	0	0	0	0	0	0	1	4592	11	1	4		4	DMTF1	7	86815172	Silent	SNP	A	TCGA-28-2501-01A-01D-1696-08	4230371	86815172	72323491	32	14249											
CNTNAP2	26047	broad.mit.edu	37	chr7	146997320	146997320	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccatcgatggagatgaagCatcagcagttcgaactaata	9	9	1	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr7:146997320C>T	uc003weu.1	+	9	1952	c.1436C>T	c.(1435-1437)GCA>GTA	p.A479V		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	479	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGAGATGAAGCATCAGCAGTT	0.428										HNSCC(39;0.1)			T	146997320	T	T	146997320	3	4	202	1	0	0	0	0	1	0	0	0	3647	710	25	3	1470	3	CNTNAP2	7	146997320	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	60182148	146997320	12141343	33	14250											
DOCK8	81704	broad.mit.edu	37	chr9	404947	404947	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagctcagtaaccttccaacGctcatttccatgaggctaga	7	12	2	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr9:404947G>A	uc003zgf.2	+	27	3376	c.3264G>A	c.(3262-3264)ACG>ACA	p.T1088T	DOCK8_uc010mgu.2_Silent_p.T390T|DOCK8_uc010mgv.2_Silent_p.T988T|DOCK8_uc010mgw.1_Silent_p.T390T|DOCK8_uc003zgk.2_Silent_p.T546T	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1088					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ACCTTCCAACGCTCATTTCCA	0.418													A	404947	A	A	404947	2	1	202	1	0	0	0	0	0	0	0	1	4693	1074	38	1		1	DOCK8	9	404947	Silent	SNP	G	TCGA-28-2501-01A-01D-1696-08		404947	140808484	34	14251											
ANKS6	203286	broad.mit.edu	37	chr9	101533299	101533299	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggctgggcttctggggagGcttggaaatttaacaggcct	16	7	1	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr9:101533299G>A	uc004ayu.2	-	10	1872	c.1851C>T	c.(1849-1851)AGC>AGT	p.S617S	ANKS6_uc004ayt.2_Silent_p.S316S|ANKS6_uc004ayv.1_Silent_p.S79S|ANKS6_uc004ayw.1_Silent_p.S199S|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	617	Ser-rich.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				TTCTGGGGAGGCTTGGAAATT	0.582													A	101533299	A	A	101533299	2	1	202	1	0	0	0	0	0	0	0	1	692	1194	42	3		3	ANKS6	9	101533299	Silent	SNP	G	TCGA-28-2501-01A-01D-1696-08	101128352	101533299	39680132	35	14252											
BRD3	8019	broad.mit.edu	37	chr9	136918434	136918434	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggctggtagaagggccaggCgaactggtgtttccagagcg	18	8	0	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr9:136918434C>T	uc004cew.2	-	2	354	c.166G>A	c.(166-168)GCC>ACC	p.A56T	BRD3_uc004cex.2_Missense_Mutation_p.A56T	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	56	Bromo 1.					nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		AAGGGCCAGGCGAACTGGTGT	0.617			T	NUT|C15orf55	lethal midline carcinoma of young people								T	136918434	T	T	136918434	3	4	202	1	0	0	0	0	1	0	0	0	1503	768	27	1	2058	1	BRD3	9	136918434	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	35385135	136918434	4294997	36	14253											
MYO3A	53904	broad.mit.edu	37	chr10	26465747	26465747	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accataagccaattaatagaCgagtttcttctcagcagtgc	7	10	2	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr10:26465747C>T	uc001isn.2	+	31	4771	c.4411C>T	c.(4411-4413)CGA>TGA	p.R1471*	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1471					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AATTAATAGACGAGTTTCTTC	0.378													T	26465747	T	T	26465747	4	4	202	1	0	0	0	0	0	1	0	0	10076	528	19	1	4525	1	MYO3A	10	26465747	Nonsense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08		26465747	109069000	37	14254											
OR5D16	390144	broad.mit.edu	37	chr11	55606359	55606359	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcttcagtgtggtagggaaTcttgggatgatagtgatcat	15	4	3	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr11:55606359T>C	uc010rio.1	+	1	132	c.132T>C	c.(130-132)AAT>AAC	p.N44N		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TGGTAGGGAATCTTGGGATGA	0.438													C	55606359	C	C	55606359	2	2	202	1	0	0	0	0	0	0	0	1	11156	1432	50	4		4	OR5D16	11	55606359	Silent	SNP	T	TCGA-28-2501-01A-01D-1696-08		55606359	79400157	38	14255											
OR5AR1	219493	broad.mit.edu	37	chr11	56431688	56431688	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggttccaatatcatcaatcAtttcttctgcgaaatcccac	4	12	5	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr11:56431688A>G	uc010rjm.1	+	1	527	c.527A>G	c.(526-528)CAT>CGT	p.H176R		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATCATCAATCATTTCTTCTGC	0.488													G	56431688	G	G	56431688	3	3	202	1	0	0	0	0	1	0	0	0	11145	217	8	4	529	4	OR5AR1	11	56431688	Missense_Mutation	SNP	A	TCGA-28-2501-01A-01D-1696-08	825329	56431688	78574828	39	14256											
LRRC32	2615	broad.mit.edu	37	chr11	76372493	76372493	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaagggtctcagtgtctggCgggagcaccgaggggacctg	17	10	3	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr11:76372493C>T	uc001oxq.3	-	3	387	c.144G>A	c.(142-144)CCG>CCA	p.P48P	LRRC32_uc001oxr.3_Silent_p.P48P|LRRC32_uc010rsf.1_Silent_p.P48P	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	48	Extracellular (Potential).					integral to plasma membrane					0						CAGTGTCTGGCGGGAGCACCG	0.622													T	76372493	T	T	76372493	2	4	202	1	0	0	0	0	0	0	0	1	8987	755	27	1		1	LRRC32	11	76372493	Silent	SNP	C	TCGA-28-2501-01A-01D-1696-08	19940805	76372493	58634023	40	14257											
PTPRR	5801	broad.mit.edu	37	chr12	71078010	71078010	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttgatcatggggccctgcGtggcaatgaaggctttctcc	13	10	2	2	rs150540173		TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr12:71078010G>A	uc001swi.1	-	10	1810	c.1394C>T	c.(1393-1395)ACG>ATG	p.T465M	PTPRR_uc001swh.1_Missense_Mutation_p.T220M|PTPRR_uc009zrs.2_Missense_Mutation_p.T314M|PTPRR_uc010stq.1_Missense_Mutation_p.T353M|PTPRR_uc010str.1_Missense_Mutation_p.T314M	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	465	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GGGGCCCTGCGTGGCAATGAA	0.433													A	71078010	A	A	71078010	3	1	202	1	0	0	0	0	1	0	0	0	12810	1145	40	1	599	1	PTPRR	12	71078010	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08		71078010	62773885	41	14258											
CHD8	57680	broad.mit.edu	37	chr14	21897194	21897194	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttgtcctggtcccattatctGagcctgctgtacagaggaca	10	11	1	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr14:21897194G>A	uc001was.1	-	3	401	c.307C>T	c.(307-309)CAG>TAG	p.Q103*	CHD8_uc001war.1_5'UTR	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	382	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CCCATTATCTGAGCCTGCTGT	0.517													A	21897194	A	A	21897194	4	1	202	1	0	0	0	0	0	1	0	0	3331	1299	45	3	6745	3	CHD8	14	21897194	Nonsense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08		21897194	85452346	42	14259											
EPB42	2038	broad.mit.edu	37	chr15	43499515	43499515	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcaactccagtgtcccatcCtcacagcacttccagaccac	5	18	2	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr15:43499515C>T	uc001zra.3	-	9	1500	c.1200G>A	c.(1198-1200)GAG>GAA	p.E400E	EPB42_uc001zqz.3_Silent_p.E67E|EPB42_uc010bde.2_Silent_p.E245E|EPB42_uc001zrb.3_Silent_p.E430E|EPB42_uc010udm.1_Silent_p.E322E	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	400					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GTGTCCCATCCTCACAGCACT	0.552													T	43499515	T	T	43499515	2	4	202	1	0	0	0	0	0	0	0	1	5158	680	24	3		3	EPB42	15	43499515	Silent	SNP	C	TCGA-28-2501-01A-01D-1696-08		43499515	59031877	43	14260											
CILP	8483	broad.mit.edu	37	chr15	65489544	65489544	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggcagctgccctgggggatgAccttcaccagggtgcggtcc	16	13	1	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr15:65489544A>G	uc002aon.2	-	9	3261	c.3080T>C	c.(3079-3081)GTC>GCC	p.V1027A		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	1027					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CTGGGGGATGACCTTCACCAG	0.592													G	65489544	G	G	65489544	3	3	202	1	0	0	0	0	1	0	0	0	3429	275	10	4	478	4	CILP	15	65489544	Missense_Mutation	SNP	A	TCGA-28-2501-01A-01D-1696-08	21990029	65489544	37041848	44	14261											
C15orf17	57184	broad.mit.edu	37	chr15	75198690	75198690	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccgcagaacggccttggcCaggtcccggtgcttctctgg	13	15	1	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr15:75198690C>T	uc002azh.3	-	2	552	c.231G>A	c.(229-231)CTG>CTA	p.L77L	C15orf17_uc010bkh.2_5'UTR|C15orf17_uc002azg.2_Silent_p.L77L|C15orf17_uc002azf.2_Silent_p.L77L	NM_020447	NP_065180	Q5XKK7	CO017_HUMAN	hypothetical protein LOC57184	77							cytochrome-c oxidase activity				0						CGGCCTTGGCCAGGTCCCGGT	0.657													T	75198690	T	T	75198690	2	4	202	1	0	0	0	0	0	0	0	1	1783	581	21	3		3	C15orf17	15	75198690	Silent	SNP	C	TCGA-28-2501-01A-01D-1696-08	9709146	75198690	27332702	45	14262											
DNAH2	146754	broad.mit.edu	37	chr17	7643079	7643079	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtcagtatcacttcgcccGctgggaagatggcaagcagg	13	11	2	1	rs145686578		TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr17:7643079G>A	uc002giu.1	+	8	1213	c.1199G>A	c.(1198-1200)CGC>CAC	p.R400H	DNAH2_uc002git.2_Missense_Mutation_p.R482H|DNAH2_uc010vuk.1_Missense_Mutation_p.R400H	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	400	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CACTTCGCCCGCTGGGAAGAT	0.483													A	7643079	A	A	7643079	3	1	202	1	0	0	0	0	1	0	0	0	4602	1087	38	1	1229	1	DNAH2	17	7643079	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08		7643079	73552131	46	14263											
DNAH9	1770	broad.mit.edu	37	chr17	11650946	11650946	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tggcgctggtaccggcaagtCacaggtgctgaggtccttgc	15	11	1	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr17:11650946C>T	uc002gne.2	+	32	6541	c.6473C>T	c.(6472-6474)TCA>TTA	p.S2158L	DNAH9_uc010coo.2_Missense_Mutation_p.S1452L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2158	AAA 2 (By similarity).|ATP (Potential).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACCGGCAAGTCACAGGTGCTG	0.562													T	11650946	T	T	11650946	3	4	202	1	0	0	0	0	1	0	0	0	4608	838	29	3	6599	3	DNAH9	17	11650946	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	4007867	11650946	69544264	47	14264											
ITGB3	3690	broad.mit.edu	37	chr17	45376748	45376748	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actactgcaactgtaccacgCgtactgacacctgcatgtcc	7	15	0	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr17:45376748C>T	uc002ilj.2	+	11	1785	c.1765C>T	c.(1765-1767)CGT>TGT	p.R589C	ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	589	Extracellular (Potential).|III.|Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	CTGTACCACGCGTACTGACAC	0.607													T	45376748	T	T	45376748	3	4	202	1	0	0	0	0	1	0	0	0	7895	768	27	1	1807	1	ITGB3	17	45376748	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	33725802	45376748	35818462	48	14265											
SPAG9	9043	broad.mit.edu	37	chr17	49062314	49062314	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgaaagattgcaagggtgcCgtcagccagggctactaaca	13	9	1	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr17:49062314C>T	uc002itc.2	-	24	3267	c.3058G>A	c.(3058-3060)GGC>AGC	p.G1020S	SPAG9_uc002itb.2_Missense_Mutation_p.G1006S|SPAG9_uc002itd.2_Missense_Mutation_p.G1010S|SPAG9_uc002ita.2_Missense_Mutation_p.G863S	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	1020					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			GCAAGGGTGCCGTCAGCCAGG	0.458													T	49062314	T	T	49062314	3	4	202	1	0	0	0	0	1	0	0	0	14985	652	23	2	935	2	SPAG9	17	49062314	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	3685566	49062314	32132896	49	14266											
CD300LB	124599	broad.mit.edu	37	chr17	72521999	72521999	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctccatggtcacagtgaaCgtgcggtctttctgattgtc	10	12	3	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr17:72521999C>T	uc002jkx.2	-	2	382	c.369G>A	c.(367-369)ACG>ACA	p.T123T	CD300LB_uc010wqz.1_Silent_p.T123T	NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	86	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						TCACAGTGAACGTGCGGTCTT	0.517													T	72521999	T	T	72521999	2	4	202	1	0	0	0	0	0	0	0	1	2999	523	19	1		1	CD300LB	17	72521999	Silent	SNP	C	TCGA-28-2501-01A-01D-1696-08	23459685	72521999	8673211	50	14267											
EVPL	2125	broad.mit.edu	37	chr17	74005267	74005267	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggcccgcctcttctgggccGcctcccgcacctcctggcgg	12	21	2	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr17:74005267G>A	uc002jqi.2	-	22	4247	c.4019C>T	c.(4018-4020)GCG>GTG	p.A1340V	EVPL_uc010wss.1_Missense_Mutation_p.A1362V|EVPL_uc010wst.1_Missense_Mutation_p.A810V	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1340	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CTTCTGGGCCGCCTCCCGCAC	0.672													A	74005267	A	A	74005267	3	1	202	1	0	0	0	0	1	0	0	0	5292	1087	38	1	2086	1	EVPL	17	74005267	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08	1483268	74005267	7189943	51	14268											
ENGASE	64772	broad.mit.edu	37	chr17	77073797	77073797	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atcagcttttacttgtcttcGctggaggagctcttggcgtg	12	9	3	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr17:77073797G>T	uc002jwv.2	+	3	275	c.267G>T	c.(265-267)TCG>TCT	p.S89S	ENGASE_uc002jwu.1_Silent_p.S89S|ENGASE_uc010wtz.1_5'UTR|ENGASE_uc002jww.2_5'Flank	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	89						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						ACTTGTCTTCGCTGGAGGAGC	0.527													T	77073797	T	T	77073797	2	4	202	1	0	0	0	0	0	0	0	1	5118	1074	38	5		5	ENGASE	17	77073797	Silent	SNP	G	TCGA-28-2501-01A-01D-1696-08	3068530	77073797	4121413	52	14269											
DENND1C	79958	broad.mit.edu	37	chr19	6479059	6479059	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgctgcacggcggggctgGggggctccctggagtgggaa	20	9	0	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr19:6479059G>A	uc002mfe.2	-	5	277	c.185C>T	c.(184-186)CCC>CTC	p.P62L	DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Missense_Mutation_p.P18L	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	62	UDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						GGCGGGGCTGGGGGGCTCCCT	0.632													A	6479059	A	A	6479059	3	1	202	1	0	0	0	0	1	0	0	0	4428	1232	43	3	2296	3	DENND1C	19	6479059	Missense_Mutation	SNP	G	TCGA-28-2501-01A-01D-1696-08		6479059	52649924	53	14270											
MUC16	94025	broad.mit.edu	37	chr19	9069613	9069613	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggctacttcctgatactgCggaataaagagatgaatgtg	13	6	0	3			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr19:9069613C>T	uc002mkp.2	-	3	18037	c.17833G>A	c.(17833-17835)GCA>ACA	p.A5945T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5947	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTGATACTGCGGAATAAAGA	0.512													T	9069613	T	T	9069613	3	4	202	1	0	0	0	0	1	0	0	0	9973	768	27	1	26018	1	MUC16	19	9069613	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08	2590554	9069613	50059370	54	14271											
MC3R	4159	broad.mit.edu	37	chr20	54824818	54824818	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttccggagcctggaattgCgcaacacctttagggagatt	11	10	0	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr20:54824818C>T	uc002xxb.2	+	1	1031	c.919C>T	c.(919-921)CGC>TGC	p.R307C		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	344	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding	p.R344C(1)		ovary(2)|breast(2)	4			Colorectal(105;0.202)			CCTGGAATTGCGCAACACCTT	0.517													T	54824818	T	T	54824818	3	4	202	1	0	0	0	0	1	0	0	0	9365	768	27	1	921	1	MC3R	20	54824818	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08		54824818	8200702	55	14272											
TPTE	7179	broad.mit.edu	37	chr21	10969096	10969096	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttcactgataggtgacaccCgggctgctcctttaaattca	8	11	2	2			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr21:10969096C>T	uc002yip.1	-	7	520	c.152G>A	c.(151-153)CGG>CAG	p.R51Q	TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	51					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGGTGACACCCGGGCTGCTCC	0.328													T	10969096	T	T	10969096	3	4	202	1	0	0	0	0	1	0	0	0	16427	652	23	2	1575	2	TPTE	21	10969096	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08		10969096	37160799	56	14273											
C21orf29	54084	broad.mit.edu	37	chr21	45948429	45948429	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgtcttccacctcggtacaCggtggctggggtcccagcgt	14	14	1	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr21:45948429C>T	uc002zfe.1	-	6	894	c.828G>A	c.(826-828)CCG>CCA	p.P276P	C21orf29_uc010gpv.1_Silent_p.P208P	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	276					cell adhesion	extracellular region	structural molecule activity				0						CCTCGGTACACGGTGGCTGGG	0.577													T	45948429	T	T	45948429	2	4	202	1	0	0	0	0	0	0	0	1	2124	523	19	1		1	C21orf29	21	45948429	Silent	SNP	C	TCGA-28-2501-01A-01D-1696-08	34979333	45948429	2181466	57	14274											
MYO18B	84700	broad.mit.edu	37	chr22	26228907	26228907	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtgttcctgtgcagtttgaCctcccggacccctccccagg	11	16	0	1			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chr22:26228907C>A	uc003abz.1	+	16	3253	c.3003C>A	c.(3001-3003)GAC>GAA	p.D1001E	MYO18B_uc003aca.1_Missense_Mutation_p.D882E|MYO18B_uc010guy.1_Missense_Mutation_p.D882E|MYO18B_uc010guz.1_Missense_Mutation_p.D882E|MYO18B_uc011aka.1_Missense_Mutation_p.D155E|MYO18B_uc011akb.1_Missense_Mutation_p.D514E	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1001	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TGCAGTTTGACCTCCCGGACC	0.507													A	26228907	A	A	26228907	3	1	202	1	0	0	0	0	1	0	0	0	10066	506	18	5	3061	5	MYO18B	22	26228907	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08		26228907	25075659	58	14275											
FMR1NB	158521	broad.mit.edu	37	chrX	147088330	147088330	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttttcatcatcggggaccaCgagcttcaaatgttttgctc	8	10	3	0			TCGA-28-2501-01A-01D-1696-08	TCGA-28-2501-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	2a2cb25d-4069-4824-b09d-2d49634ed284	575c728e-f69f-4680-b7b8-ff3c62421402	g.chrX:147088330C>T	uc004fcm.2	+	3	580	c.506C>T	c.(505-507)ACG>ATG	p.T169M		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	169	P-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCGGGGACCACGAGCTTCAAA	0.363													T	147088330	T	T	147088330	3	4	202	1	0	0	0	0	1	0	0	0	5961	536	19	1	516	1	FMR1NB	23	147088330	Missense_Mutation	SNP	C	TCGA-28-2501-01A-01D-1696-08		147088330	8182230	59	14276											
MTOR	2475	broad.mit.edu	37	chr1	11188183	11188183	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtcagtgggtagatgagggCctgagggaaaaacagaagaa	16	4	1	5			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr1:11188183C>T	uc001asd.2	-	43	6032	c.5911G>A	c.(5911-5913)GCC>ACC	p.A1971T	MTOR_uc001asc.2_Missense_Mutation_p.A176T	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1971	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TAGATGAGGGCCTGAGGGAAA	0.458													T	11188183	T	T	11188183	3	4	203	1	0	0	0	0	1	0	0	0	9954	753	26	3	1802	3	MTOR	1	11188183	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08		11188183	238062438	1	14277											
C1QC	714	broad.mit.edu	37	chr1	22973963	22973963	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcctgatcagattcaacgCggtcctcaccaacccgcagg	9	16	3	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr1:22973963C>T	uc001bgc.3	+	3	528	c.425C>T	c.(424-426)GCG>GTG	p.A142V	C1QC_uc001bga.3_Missense_Mutation_p.A142V|C1QC_uc001bgb.2_Missense_Mutation_p.A142V	NM_172369	NP_758957	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	142	C1q.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen					0		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGATTCAACGCGGTCCTCACC	0.567													T	22973963	T	T	22973963	3	4	203	1	0	0	0	0	1	0	0	0	1957	768	27	1	431	1	C1QC	1	22973963	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	11785780	22973963	226276658	2	14278											
SPOCD1	90853	broad.mit.edu	37	chr1	32279589	32279589	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggctgggttcctctggcCtgtcctggtgggagttgtct	16	10	2	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr1:32279589C>T	uc001bts.1	-	2	1404	c.1346G>A	c.(1345-1347)AGG>AAG	p.R449K	SPOCD1_uc001btu.2_Missense_Mutation_p.R449K|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	449					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TTCCTCTGGCCTGTCCTGGTG	0.567													T	32279589	T	T	32279589	3	4	203	1	0	0	0	0	1	0	0	0	15077	681	24	3	2364	3	SPOCD1	1	32279589	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	9305626	32279589	216971032	3	14279											
LPAR3	23566	broad.mit.edu	37	chr1	85331474	85331474	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggaagcagtcaagctactGtccagaagcccctgacggag	13	11	1	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr1:85331474G>A	uc001dkl.2	-	1	369	c.330C>T	c.(328-330)GAC>GAT	p.D110D	LPAR3_uc009wcj.1_Silent_p.D110D	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	110	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						TCAAGCTACTGTCCAGAAGCC	0.493													A	85331474	A	A	85331474	2	1	203	1	0	0	0	0	0	0	0	1	8906	1368	48	3		3	LPAR3	1	85331474	Silent	SNP	G	TCGA-28-2502-01B-01D-1494-08	53051885	85331474	163919147	4	14280											
WDR63	126820	broad.mit.edu	37	chr1	85564213	85564213	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tttcttttaatatttttcagCctatgtttctccttgaaccg	4	9	3	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr1:85564213C>G	uc001dkt.2	+	13	1542	c.1351C>G	c.(1351-1353)CCT>GCT	p.P451A	WDR63_uc009wcl.2_Missense_Mutation_p.P412A	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	451										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TATTTTTCAGCCTATGTTTCT	0.318													G	85564213	G	G	85564213	3	3	203	1	0	0	0	0	1	0	0	0	17311	753	26	5	1397	5	WDR63	1	85564213	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	232739	85564213	163686408	5	14281											
ADAM30	11085	broad.mit.edu	37	chr1	120438173	120438173	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taactctggatatccaacgcGtattttgttaaaatctgtcc	6	9	2	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr1:120438173G>A	uc001eij.2	-	1	941	c.787C>T	c.(787-789)CGC>TGC	p.R263C		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	263	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TATCCAACGCGTATTTTGTTA	0.358													A	120438173	A	A	120438173	3	1	203	1	0	0	0	0	1	0	0	0	248	1145	40	1	1589	1	ADAM30	1	120438173	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	34873960	120438173	128812448	6	14282											
FLG	2312	broad.mit.edu	37	chr1	152277058	152277058	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcttgaccccgggtgtccaCgaatggtgtcctgaccctct	11	14	1	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr1:152277058C>T	uc001ezu.1	-	3	10340	c.10304G>A	c.(10303-10305)CGT>CAT	p.R3435H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3435	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGGGTGTCCACGAATGGTGTC	0.602									Ichthyosis				T	152277058	T	T	152277058	3	4	203	1	0	0	0	0	1	0	0	0	5922	536	19	1	1885	1	FLG	1	152277058	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	31838885	152277058	96973563	7	14283											
FBLN2	2199	broad.mit.edu	37	chr3	13679189	13679189	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atatcttccgcattggccccGcgccagccttcacgggggac	11	16	2	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr3:13679189G>A	uc011avb.1	+	17	3450	c.3325G>A	c.(3325-3327)GCG>ACG	p.A1109T	FBLN2_uc011auz.1_Missense_Mutation_p.A1135T|FBLN2_uc011ava.1_Missense_Mutation_p.A1156T|FBLN2_uc011avc.1_Missense_Mutation_p.A1156T	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	1109	Domain III.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CATTGGCCCCGCGCCAGCCTT	0.622													A	13679189	A	A	13679189	3	1	203	1	0	0	0	0	1	0	0	0	5699	1087	38	1	2222	1	FBLN2	3	13679189	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08		13679189	184343241	8	14284											
SCN10A	6336	broad.mit.edu	37	chr3	38833608	38833608	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actgaatagccacagggcccGagtggcactaaaccgggaaa	12	11	0	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr3:38833608G>A	uc003ciq.2	-	2	322	c.322C>T	c.(322-324)CGG>TGG	p.R108W		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	108					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CACAGGGCCCGAGTGGCACTA	0.463													A	38833608	A	A	38833608	3	1	203	1	0	0	0	0	1	0	0	0	13912	1057	37	2	5652	2	SCN10A	3	38833608	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	25154419	38833608	159188822	9	14285											
CCDC71	64925	broad.mit.edu	37	chr3	49200468	49200468	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atcttttgcctcctcagcccTtttcctcttctgcccaacag	4	17	4	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr3:49200468T>C	uc003cwg.3	-	2	1312	c.1174A>G	c.(1174-1176)AGG>GGG	p.R392G		NM_022903	NP_075054	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	392										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCCTCAGCCCTTTTCCTCTTC	0.572													C	49200468	C	C	49200468	3	2	203	1	0	0	0	0	1	0	0	0	2844	1608	56	4	233	4	CCDC71	3	49200468	Missense_Mutation	SNP	T	TCGA-28-2502-01B-01D-1494-08	10366860	49200468	148821962	10	14286											
GPR128	84873	broad.mit.edu	37	chr3	100365559	100365559	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaccatactactaattttgcTgtattaatggtaaggatata	6	5	0	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr3:100365559T>C	uc003duc.2	+	10	1525	c.1257T>C	c.(1255-1257)GCT>GCC	p.A419A	GPR128_uc011bhc.1_Silent_p.A120A	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	419	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						CTAATTTTGCTGTATTAATGG	0.413													C	100365559	C	C	100365559	2	2	203	1	0	0	0	0	0	0	0	1	6641	1567	55	4		4	GPR128	3	100365559	Silent	SNP	T	TCGA-28-2502-01B-01D-1494-08	51165091	100365559	97656871	11	14287											
PHLDB2	90102	broad.mit.edu	37	chr3	111603461	111603461	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tctggctcgctcctggccatGtggaatggaagttccctgag	13	11	1	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr3:111603461G>C	uc010hqa.2	+	2	948	c.537G>C	c.(535-537)ATG>ATC	p.M179I	PHLDB2_uc003dyc.2_Missense_Mutation_p.M206I|PHLDB2_uc003dyd.2_Missense_Mutation_p.M179I|PHLDB2_uc003dyg.2_Missense_Mutation_p.M179I|PHLDB2_uc003dyh.2_Missense_Mutation_p.M179I|PHLDB2_uc003dye.3_Missense_Mutation_p.M179I|PHLDB2_uc003dyf.3_Missense_Mutation_p.M179I	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	179						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TCCTGGCCATGTGGAATGGAA	0.537													C	111603461	C	C	111603461	3	2	203	1	0	0	0	0	1	0	0	0	11852	1377	48	5	624	5	PHLDB2	3	111603461	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	11237902	111603461	86418969	12	14288											
CASR	846	broad.mit.edu	37	chr3	122003132	122003132	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atggccctgggcttcctgatCggctacacctgcctgctggc	12	15	0	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr3:122003132C>T	uc003eev.3	+	7	2703	c.2331C>T	c.(2329-2331)ATC>ATT	p.I777I	CASR_uc003eew.3_Silent_p.I787I	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	777	Helical; Name=5; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCTTCCTGATCGGCTACACCT	0.582													T	122003132	T	T	122003132	2	4	203	1	0	0	0	0	0	0	0	1	2682	874	31	2		2	CASR	3	122003132	Silent	SNP	C	TCGA-28-2502-01B-01D-1494-08	10399671	122003132	76019298	13	14289											
UGT2B28	54490	broad.mit.edu	37	chr4	70146911	70146911	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caaatgtgtgatatgaagaaGtgggatcagttttacagtga	12	3	1	4			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr4:70146911G>T	uc003hej.2	+	1	695	c.693G>T	c.(691-693)AAG>AAT	p.K231N	UGT2B28_uc010ihr.2_Missense_Mutation_p.K231N	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	231					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	ATATGAAGAAGTGGGATCAGT	0.323													T	70146911	T	T	70146911	3	4	203	1	0	0	0	0	1	0	0	0	16957	1020	36	5	695	5	UGT2B28	4	70146911	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08		70146911	121007365	14	14290											
INTS12	57117	broad.mit.edu	37	chr4	106604288	106604288	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccagaccagtcaaacccaCaggtttctggttagctgacg	10	12	2	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr4:106604288C>T	uc003hxw.2	-	8	1249	c.991G>A	c.(991-993)GTG>ATG	p.V331M	INTS12_uc010ilr.2_Missense_Mutation_p.V331M	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	331	Ser-rich.				snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		GTCAAACCCACAGGTTTCTGG	0.448													T	106604288	T	T	106604288	3	4	203	1	0	0	0	0	1	0	0	0	7777	478	17	3	401	3	INTS12	4	106604288	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	36457377	106604288	84549988	15	14291											
CDH18	1016	broad.mit.edu	37	chr5	19544080	19544080	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	attggcatcaatgttgaaaaAtctgtcgtcttcaacattgt	7	7	4	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr5:19544080A>T	uc003jgc.2	-	8	1665	c.1288T>A	c.(1288-1290)TTT>ATT	p.F430I	CDH18_uc003jgd.2_Missense_Mutation_p.F430I|CDH18_uc011cnm.1_Missense_Mutation_p.F430I	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	430	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ATGTTGAAAAATCTGTCGTCT	0.353													T	19544080	T	T	19544080	3	4	203	1	0	0	0	0	1	0	0	0	3103	101	4	5	1104	5	CDH18	5	19544080	Missense_Mutation	SNP	A	TCGA-28-2502-01B-01D-1494-08		19544080	161371180	16	14292											
MAP1B	4131	broad.mit.edu	37	chr5	71490832	71490832	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtctgaagccagccgcaaaAccacttcctagcaaatccgt	7	14	1	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr5:71490832A>G	uc003kbw.3	+	5	1891	c.1650A>G	c.(1648-1650)AAA>AAG	p.K550K	MAP1B_uc010iyw.1_Silent_p.K567K|MAP1B_uc010iyx.1_Silent_p.K424K|MAP1B_uc010iyy.1_Silent_p.K424K	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	550						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CAGCCGCAAAACCACTTCCTA	0.493													G	71490832	G	G	71490832	2	3	203	1	0	0	0	0	0	0	0	1	9228	40	2	4		4	MAP1B	5	71490832	Silent	SNP	A	TCGA-28-2502-01B-01D-1494-08	51946752	71490832	109424428	17	14293											
HIST1H2BA	255626	broad.mit.edu	37	chr6	25727356	25727356	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgtcactgatatctttgagCgtatagcgagcgaggcatca	11	9	3	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr6:25727356C>T	uc003nfd.2	+	1	220	c.220C>T	c.(220-222)CGT>TGT	p.R74C	HIST1H2AA_uc003nfc.2_5'Flank	NM_170610	NP_733759	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	74					nucleosome assembly	nucleosome|nucleus	DNA binding			kidney(1)	1						TATCTTTGAGCGTATAGCGAG	0.483													T	25727356	T	T	25727356	3	4	203	1	0	0	0	0	1	0	0	0	7140	768	27	1	222	1	HIST1H2BA	6	25727356	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08		25727356	145387711	18	14294											
HIST1H2BE	8344	broad.mit.edu	37	chr6	26184091	26184093	+	In_Frame_Del	DEL	AGA	-	-													gaaggccgtgaccaaggcgcAgaagaaggacggcaagaagc							TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr6:26184091_26184093delAGA	uc003ngt.2	+	1	68_70	c.68_70delAGA	c.(67-72)CAGAAG>CAG	p.K25del		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	25					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						ACCAAGGCGCAGAAGAAGGACGG	0.576													-	26184093	-	-	26184091	7	5	203	1	0	1	0	1	0	0	0	0	7144	188	7	0	70	0	HIST1H2BE	6	26184091	In_Frame_Del	DEL	AGA	TCGA-28-2502-01B-01D-1494-08	456735	26184091	144930976	19	14295											
TRIM10	10107	broad.mit.edu	37	chr6	30121907	30121907	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagagacaccctcacctgccGgggctgctccttcagggtca	11	15	3	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr6:30121907G>A	uc003npo.3	-	7	1361	c.1285C>T	c.(1285-1287)CGG>TGG	p.R429W	TRIM10_uc003npn.2_Intron	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	429	B30.2/SPRY.					cytoplasm	zinc ion binding				0						CTCACCTGCCGGGGCTGCTCC	0.642													A	30121907	A	A	30121907	3	1	203	1	0	0	0	0	1	0	0	0	16483	1115	39	2	252	2	TRIM10	6	30121907	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	3937816	30121907	140993160	20	14296											
MICB	4277	broad.mit.edu	37	chr6	31474137	31474137	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagaccaagacacactatcgCgctatgcaggcagactgcct	9	13	0	3			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr6:31474137C>T	uc003ntn.3	+	3	659	c.543C>T	c.(541-543)CGC>CGT	p.R181R	MICB_uc011dnm.1_Silent_p.R149R|MICB_uc003nto.3_Silent_p.R138R	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	181	Extracellular (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						CACACTATCGCGCTATGCAGG	0.532													T	31474137	T	T	31474137	2	4	203	1	0	0	0	0	0	0	0	1	9575	755	27	1		1	MICB	6	31474137	Silent	SNP	C	TCGA-28-2502-01B-01D-1494-08	1352230	31474137	139640930	21	14297											
MEP1A	4224	broad.mit.edu	37	chr6	46797155	46797155	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cggaagaggcagccctactgGagtctcggattctttaccca	11	12	2	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr6:46797155G>A	uc010jzh.1	+	10	1033	c.991G>A	c.(991-993)GAG>AAG	p.E331K	MEP1A_uc011dwg.1_Missense_Mutation_p.E53K|MEP1A_uc011dwh.1_Missense_Mutation_p.E359K|MEP1A_uc011dwi.1_Missense_Mutation_p.E231K	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	331	Extracellular (Potential).|MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			AGCCCTACTGGAGTCTCGGAT	0.532													A	46797155	A	A	46797155	3	1	203	1	0	0	0	0	1	0	0	0	9475	1175	41	3	1029	3	MEP1A	6	46797155	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	15323018	46797155	124317912	22	14298											
GPR116	221395	broad.mit.edu	37	chr6	46845996	46845996	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tttgctccaattaacattacCctgactgcagcagttcaaag	6	11	1	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr6:46845996C>A	uc003oyo.3	-	10	1472	c.1183G>T	c.(1183-1185)GGT>TGT	p.G395C	GPR116_uc003oyp.3_Intron|GPR116_uc003oyq.3_Missense_Mutation_p.G395C|GPR116_uc010jzi.1_Missense_Mutation_p.G67C|GPR116_uc003oyr.2_Missense_Mutation_p.G395C	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	395	Ig-like 2.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			TTAACATTACCCTGACTGCAG	0.373													A	46845996	A	A	46845996	3	1	203	1	0	0	0	0	1	0	0	0	6633	623	22	5	2905	5	GPR116	6	46845996	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	48841	46845996	124269071	23	14299											
SYNE1	23345	broad.mit.edu	37	chr6	152527476	152527476	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgtagctgccttgttgccGcagaaacactttttctttga	9	9	1	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr6:152527476G>A	uc010kiw.2	-	126	23448	c.22846C>T	c.(22846-22848)CGG>TGG	p.R7616W	SYNE1_uc010kiv.2_Missense_Mutation_p.R2140W|SYNE1_uc003qos.3_Missense_Mutation_p.R2140W|SYNE1_uc003qot.3_Missense_Mutation_p.R7545W|SYNE1_uc003qou.3_Missense_Mutation_p.R7616W|SYNE1_uc003qor.3_Missense_Mutation_p.R516W	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7616	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTTGTTGCCGCAGAAACACT	0.483										HNSCC(10;0.0054)			A	152527476	A	A	152527476	3	1	203	1	0	0	0	0	1	0	0	0	15442	1086	38	1	3704	1	SYNE1	6	152527476	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	105681480	152527476	18587591	24	14300											
UNC93A	54346	broad.mit.edu	37	chr6	167709567	167709567	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgggactcggggccgcccCgctgtggtctgcacagtgca	16	14	1	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr6:167709567C>T	uc003qvq.2	+	3	492	c.317C>T	c.(316-318)CCG>CTG	p.P106L	UNC93A_uc003qvr.2_Missense_Mutation_p.P106L	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	106	Helical; (Potential).					integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GGGGCCGCCCCGCTGTGGTCT	0.557													T	167709567	T	T	167709567	3	4	203	1	0	0	0	0	1	0	0	0	16993	652	23	2	327	2	UNC93A	6	167709567	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	15182091	167709567	3405500	25	14301											
SDK1	221935	broad.mit.edu	37	chr7	4153883	4153883	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgggccgtggagcgaggtggTgcggggccggacgcgggagt	24	8	0	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr7:4153883T>C	uc003smx.2	+	25	3939	c.3800T>C	c.(3799-3801)GTG>GCG	p.V1267A	SDK1_uc010kso.2_Missense_Mutation_p.V543A	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1267	Fibronectin type-III 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCGAGGTGGTGCGGGGCCGG	0.637													C	4153883	C	C	4153883	3	2	203	1	0	0	0	0	1	0	0	0	13968	1696	59	4	3898	4	SDK1	7	4153883	Missense_Mutation	SNP	T	TCGA-28-2502-01B-01D-1494-08		4153883	154984780	26	14302											
ZNF679	168417	broad.mit.edu	37	chr7	63727109	63727109	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gcctttgccttctcctcaacTcttaatactcataagaggat	5	12	4	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr7:63727109T>A	uc003tsx.2	+	5	1367	c.1098T>A	c.(1096-1098)ACT>ACA	p.T366T		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	366	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TCTCCTCAACTCTTAATACTC	0.378													A	63727109	A	A	63727109	2	1	203	1	0	0	0	0	0	0	0	1	18083	1538	54	5		5	ZNF679	7	63727109	Silent	SNP	T	TCGA-28-2502-01B-01D-1494-08	59573226	63727109	95411554	27	14303											
MUC17	140453	broad.mit.edu	37	chr7	100696360	100696360	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggcctcgtgggggcaggggtCgtgctgatgctgatcatcct	17	10	1	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr7:100696360C>T	uc003uxp.1	+	10	13250	c.13197C>T	c.(13195-13197)GTC>GTT	p.V4399V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4399	Helical; (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGGCAGGGGTCGTGCTGATGC	0.587													T	100696360	T	T	100696360	2	4	203	1	0	0	0	0	0	0	0	1	9974	871	31	2		2	MUC17	7	100696360	Silent	SNP	C	TCGA-28-2502-01B-01D-1494-08	36969251	100696360	58442303	28	14304											
OR2A1	346528	broad.mit.edu	37	chr7	143929644	143929644	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaaacagagaaaggtctgcGtcatgcaaccagcaaaggag	11	9	3	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr7:143929644G>A	uc011kub.1	-	1	293	c.293C>T	c.(292-294)ACG>ATG	p.T98M		NM_001005287	NP_001005287	Q8NGT9	OR2A1_HUMAN	olfactory receptor, family 2, subfamily A,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.14)					AAAGGTCTGCGTCATGCAACC	0.572													A	143929644	A	A	143929644	3	1	203	1	0	0	0	0	1	0	0	0	10974	1145	40	1		1	OR2A1	7	143929644	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	43233284	143929644	15209019	29	14305											
NOBOX	135935	broad.mit.edu	37	chr7	144098530	144098530	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtctcccagcatcagccccGgtggcttctccagagactgc	10	16	3	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr7:144098530G>A	uc011kue.1	-	4	453	c.453C>T	c.(451-453)ACC>ACT	p.T151T		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	151					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					CATCAGCCCCGGTGGCTTCTC	0.637													A	144098530	A	A	144098530	2	1	203	1	0	0	0	0	0	0	0	1	10512	1103	39	2		2	NOBOX	7	144098530	Silent	SNP	G	TCGA-28-2502-01B-01D-1494-08	168886	144098530	15040133	30	14306											
CALB1	793	broad.mit.edu	37	chr8	91094855	91094855	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaagataatcaccgtcagcgTcgaaatggagccagatctcg	11	10	3	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr8:91094855T>C	uc003yel.1	-	1	253	c.71A>G	c.(70-72)GAC>GGC	p.D24G	CALB1_uc003yem.1_Intron|CALB1_uc011lge.1_5'Flank	NM_004929	NP_004920	P05937	CALB1_HUMAN	calbindin 1	24	1.|EF-hand 1.					nucleus	calcium ion binding|vitamin D binding			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.00953)			ACCGTCAGCGTCGAAATGGAG	0.502													C	91094855	C	C	91094855	3	2	203	1	0	0	0	0	1	0	0	0	2573	1667	58	4	758	4	CALB1	8	91094855	Missense_Mutation	SNP	T	TCGA-28-2502-01B-01D-1494-08		91094855	55269167	31	14307											
ASAP1	50807	broad.mit.edu	37	chr8	131140283	131140283	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcccgcactctgctctccaCggaaggccatggttagggcc	11	16	2	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr8:131140283C>T	uc003yta.1	-	15	1299	c.1271G>A	c.(1270-1272)CGT>CAT	p.R424H	ASAP1_uc003ysz.1_Missense_Mutation_p.R235H|ASAP1_uc011liw.1_Missense_Mutation_p.R417H	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	424					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CTGCTCTCCACGGAAGGCCAT	0.458													T	131140283	T	T	131140283	3	4	203	1	0	0	0	0	1	0	0	0	1010	536	19	1	2178	1	ASAP1	8	131140283	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	40045428	131140283	15223739	32	14308											
ANKS6	203286	broad.mit.edu	37	chr9	101530471	101530471	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggctgggtttctgctccaaTaatccggctgcttttttcct	9	11	1	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr9:101530471T>A	uc004ayu.2	-	11	2055	c.2034A>T	c.(2032-2034)TTA>TTT	p.L678F	ANKS6_uc004ayt.2_Missense_Mutation_p.L377F|ANKS6_uc004ayv.1_Missense_Mutation_p.L140F|ANKS6_uc004ayw.1_Missense_Mutation_p.L260F|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	678	Ser-rich.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				TCTGCTCCAATAATCCGGCTG	0.582													A	101530471	A	A	101530471	3	1	203	1	0	0	0	0	1	0	0	0	692	1403	49	5	601	5	ANKS6	9	101530471	Missense_Mutation	SNP	T	TCGA-28-2502-01B-01D-1494-08		101530471	39682960	33	14309											
SMC2	10592	broad.mit.edu	37	chr9	106889054	106889054	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagtaatggcagctgaggtgGctaaaaataaggtaggattt	13	3	0	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr9:106889054G>A	uc004bbv.2	+	19	2872	c.2584G>A	c.(2584-2586)GCT>ACT	p.A862T	SMC2_uc004bbw.2_Missense_Mutation_p.A862T|SMC2_uc011lvl.1_Missense_Mutation_p.A862T|SMC2_uc004bbx.2_Missense_Mutation_p.A862T|SMC2_uc004bby.2_5'Flank	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	862	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						AGCTGAGGTGGCTAAAAATAA	0.338													A	106889054	A	A	106889054	3	1	203	1	0	0	0	0	1	0	0	0	14783	1203	42	3	2654	3	SMC2	9	106889054	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	5358583	106889054	34324377	34	14310											
COL27A1	85301	broad.mit.edu	37	chr9	117014903	117014903	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatgatgggacccccaggcGtgcctggacccaaggggtcg	16	13	0	1	rs141446597		TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr9:117014903G>A	uc011lxl.1	+	26	3064	c.3064G>A	c.(3064-3066)GTG>ATG	p.V1022M	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1022	Pro-rich.|Collagen-like 7.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ACCCCCAGGCGTGCCTGGACC	0.607													A	117014903	A	A	117014903	3	1	203	1	0	0	0	0	1	0	0	0	3685	1145	40	1	3166	1	COL27A1	9	117014903	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	10125849	117014903	24198528	35	14311											
PTEN	5728	broad.mit.edu	37	chr10	89690805	89690805	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttaaacttttcttttagttGtgctgaaagacattatgaca	6	5	1	3			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr10:89690805G>A	uc001kfb.2	+	5	1243	c.212G>A	c.(211-213)TGT>TAT	p.C71Y		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	71	Phosphatase tensin-type.		C -> Y (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.L70fs*7(4)|p.R55fs*1(4)|p.?(2)|p.C71fs*6(2)|p.Y27fs*1(2)|p.C71Y(2)|p.Y27_N212>Y(2)|p.C71fs*28(1)|p.F56fs*2(1)|p.C71W(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TCTTTTAGTTGTGCTGAAAGA	0.259		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89690805	A	A	89690805	3	1	203	1	0	0	0	0	1	0	0	0	12738	1377	48	3	226	3	PTEN	10	89690805	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08		89690805	45843942	36	14312											
CPN1	1369	broad.mit.edu	37	chr10	101835788	101835788	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactcctcgcacagaaactcCgacagctgcagcatcagctc	7	16	1	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr10:101835788C>T	uc001kql.2	-	2	560	c.300G>A	c.(298-300)TCG>TCA	p.S100S		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	100	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		ACAGAAACTCCGACAGCTGCA	0.582													T	101835788	T	T	101835788	2	4	203	1	0	0	0	0	0	0	0	1	3809	639	23	2		2	CPN1	10	101835788	Silent	SNP	C	TCGA-28-2502-01B-01D-1494-08	12144983	101835788	33698959	37	14313											
GTF2H1	2965	broad.mit.edu	37	chr11	18369172	18369172	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tgtgccatctgcttccaattCtaaatccataaaagagaata	5	9	2	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr11:18369172C>G	uc001moi.2	+	9	1569	c.875C>G	c.(874-876)TCT>TGT	p.S292C	GTF2H1_uc001moh.2_Missense_Mutation_p.S292C|GTF2H1_uc009yhm.2_Missense_Mutation_p.S176C|GTF2H1_uc001moj.2_5'UTR	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	292				S -> P (in Ref. 2; BAB15621).	mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						GCTTCCAATTCTAAATCCATA	0.358								NER					G	18369172	G	G	18369172	3	3	203	1	0	0	0	0	1	0	0	0	6860	913	32	5	901	5	GTF2H1	11	18369172	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08		18369172	116637344	38	14314											
DEPDC7	91614	broad.mit.edu	37	chr11	33049298	33049299	+	Frame_Shift_Del	DEL	TC	-	-													ttagaggacctgtgggaaaaTctgagtttaaagcctgccaa							TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr11:33049298_33049299delTC	uc001mub.2	+	3	623_624	c.531_532delTC	c.(529-534)AATCTGfs	p.N177fs	DEPDC7_uc010reh.1_Frame_Shift_Del_p.N177fs|DEPDC7_uc001muc.2_Frame_Shift_Del_p.N168fs	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	177_178					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						TGTGggaaaatctgagtttaaa	0.287													-	33049299	-	-	33049298	7	5	203	1	0	1	0	1	0	0	0	0	4444	1432	50	0	591	0	DEPDC7	11	33049298	Frame_Shift_Del	DEL	TC	TCGA-28-2502-01B-01D-1494-08	14680126	33049298	101957218	39	14315											
NUMA1	4926	broad.mit.edu	37	chr11	71729878	71729878	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagccacctacccttctcggTgaggagcttgcggttctcag	11	14	2	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr11:71729878T>C	uc001orl.1	-	10	905	c.733A>G	c.(733-735)ACC>GCC	p.T245A	NUMA1_uc009ysw.1_5'Flank|NUMA1_uc001ork.1_Missense_Mutation_p.T245A|NUMA1_uc001orm.1_Missense_Mutation_p.T245A|NUMA1_uc001orn.2_5'Flank|NUMA1_uc009ysx.1_Missense_Mutation_p.T245A|NUMA1_uc001oro.1_Missense_Mutation_p.T245A|NUMA1_uc009ysy.1_Missense_Mutation_p.T245A|NUMA1_uc001orp.2_Missense_Mutation_p.T245A|NUMA1_uc001orq.2_Missense_Mutation_p.T245A	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	245	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CCCTTCTCGGTGAGGAGCTTG	0.577			T	RARA	APL								C	71729878	C	C	71729878	3	2	203	1	0	0	0	0	1	0	0	0	10750	1696	59	4	5686	4	NUMA1	11	71729878	Missense_Mutation	SNP	T	TCGA-28-2502-01B-01D-1494-08	38680580	71729878	63276638	40	14316											
MMP3	4314	broad.mit.edu	37	chr11	102713433	102713433	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgggttttcctccacttcGggatgccaggaaaggttctg	14	9	1	0	rs151123532		TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr11:102713433G>A	uc001phj.1	-	2	385	c.320C>T	c.(319-321)CCG>CTG	p.P107L		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	107					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CCTCCACTTCGGGATGCCAGG	0.473													A	102713433	A	A	102713433	3	1	203	1	0	0	0	0	1	0	0	0	9666	1116	39	2	1149	2	MMP3	11	102713433	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	30983555	102713433	32293083	41	14317											
KDM5A	5927	broad.mit.edu	37	chr12	416884	416884	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgacagaatagtctctagCctgggccttcgagaccgcat	11	11	1	3			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr12:416884C>T	uc001qif.1	-	23	4029	c.3666G>A	c.(3664-3666)AGG>AGA	p.R1222R	KDM5A_uc001qie.1_Silent_p.R1222R	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1222					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						TAGTCTCTAGCCTGGGCCTTC	0.478			T 	NUP98	AML								T	416884	T	T	416884	2	4	203	1	0	0	0	0	0	0	0	1	8133	738	26	3		3	KDM5A	12	416884	Silent	SNP	C	TCGA-28-2502-01B-01D-1494-08		416884	133435011	42	14318											
RERGL	79785	broad.mit.edu	37	chr12	18237478	18237478	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgactagtttgtggctccCggattctgtagatcagcgct	11	9	2	2	rs61757396	byFrequency	TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr12:18237478C>T	uc001rdq.2	-	5	502	c.308G>A	c.(307-309)CGG>CAG	p.R103Q	RERGL_uc001rdr.2_Missense_Mutation_p.R102Q	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	103	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						TTGTGGCTCCCGGATTCTGTA	0.383													T	18237478	T	T	18237478	3	4	203	1	0	0	0	0	1	0	0	0	13233	652	23	2	317	2	RERGL	12	18237478	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	17820594	18237478	115614417	43	14319											
LMO7	4008	broad.mit.edu	37	chr13	76301190	76301190	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttaataagcttaaacctggcGtcattaagaagatcaataga	7	6	2	3	rs140368500	byFrequency	TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr13:76301190G>A	uc010thv.1	+	4	1582	c.322G>A	c.(322-324)GTC>ATC	p.V108I	LMO7_uc001vjt.1_Missense_Mutation_p.V56I	NM_005358	NP_005349	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 1	108	CH.					cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TAAACCTGGCGTCATTAAGAA	0.303													A	76301190	A	A	76301190	3	1	203	1	0	0	0	0	1	0	0	0	8855	1145	40	1	336	1	LMO7	13	76301190	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08		76301190	38868688	44	14320											
C14orf39	317761	broad.mit.edu	37	chr14	60938273	60938273	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aacaaaaatattaatacctcGaaatttcataaaaattgttt	2	5	1	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr14:60938273G>A	uc001xez.3	-	6	618	c.508C>T	c.(508-510)CGA>TGA	p.R170*	C14orf39_uc010apo.2_Intron	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	170										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		TTAATACCTCGAAATTTCATA	0.249													A	60938273	A	A	60938273	4	1	203	1	0	0	0	0	0	1	0	0	1772	1066	37	2	1307	2	C14orf39	14	60938273	Nonsense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08		60938273	46411267	45	14321											
RYR3	6263	broad.mit.edu	37	chr15	33855071	33855071	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aattagactccagtcacaagCgagacatagaaggcatggga	11	8	1	3			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr15:33855071C>T	uc001zhi.2	+	11	1076	c.1006C>T	c.(1006-1008)CGA>TGA	p.R336*	RYR3_uc010bar.2_Nonsense_Mutation_p.R336*	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	336	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGTCACAAGCGAGACATAGA	0.398													T	33855071	T	T	33855071	4	4	203	1	0	0	0	0	0	1	0	0	13770	760	27	1	1048	1	RYR3	15	33855071	Nonsense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08		33855071	68676321	46	14322											
EXD1	161829	broad.mit.edu	37	chr15	41488149	41488149	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accttcaaaattctcttgtcTtctagtatcatctgaagtcc	4	11	6	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr15:41488149T>G	uc001znk.2	-	6	638	c.447A>C	c.(445-447)GAA>GAC	p.E149D	EXD1_uc010ucv.1_Missense_Mutation_p.E207D	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	149					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						TTCTCTTGTCTTCTAGTATCA	0.378													G	41488149	G	G	41488149	3	3	203	1	0	0	0	0	1	0	0	0	5297	1606	56	5	1117	5	EXD1	15	41488149	Missense_Mutation	SNP	T	TCGA-28-2502-01B-01D-1494-08	7633078	41488149	61043243	47	14323											
CLCN7	1186	broad.mit.edu	37	chr16	1507256	1507256	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacaagatttcaactcaccTtgaaatctcgtttcagtgac	5	11	4	3			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr16:1507256T>C	uc002clv.2	-	9	931	c.821A>G	c.(820-822)AAG>AGG	p.K274R	CLCN7_uc002clw.2_Missense_Mutation_p.K250R	NM_001287	NP_001278	P51798	CLCN7_HUMAN	chloride channel 7 isoform a	274						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Hepatocellular(780;0.0893)				TCAACTCACCTTGAAATCTCG	0.592													C	1507256	C	C	1507256	3	2	203	1	0	0	0	0	1	0	0	0	3468	1623	56	4	1664	4	CLCN7	16	1507256	Missense_Mutation	SNP	T	TCGA-28-2502-01B-01D-1494-08		1507256	88847497	48	14324											
MKL2	57496	broad.mit.edu	37	chr16	14234551	14234551	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctcagagtgaagctgtggctCatgaattccaggaactctcc	10	11	3	3			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr16:14234551C>G	uc010uza.1	+	3	243	c.88C>G	c.(88-90)CAT>GAT	p.H30D	MKL2_uc002dcg.2_Missense_Mutation_p.H30D	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	Error:Variant_position_missing_in_Q9ULH7_after_alignment					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						AGCTGTGGCTCATGAATTCCA	0.488													G	14234551	G	G	14234551	3	3	203	1	0	0	0	0	1	0	0	0	9602	826	29	5	90	5	MKL2	16	14234551	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	12727295	14234551	76120202	49	14325											
SETD1A	9739	broad.mit.edu	37	chr16	30977133	30977133	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acctgatgggccgccgccccCtgagtaccccccacctcctc	8	22	0	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr16:30977133C>G	uc002ead.1	+	8	2617	c.1931C>G	c.(1930-1932)CCT>CGT	p.P644R		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	644	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CCGCCGCCCCCTGAGTACCCC	0.577													G	30977133	G	G	30977133	3	3	203	1	0	0	0	0	1	0	0	0	14130	681	24	5	1957	5	SETD1A	16	30977133	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	16742582	30977133	59377620	50	14326											
NF1	4763	broad.mit.edu	37	chr17	29496924	29496927	+	Frame_Shift_Del	DEL	TGTT	-	-													tttaggttacaggaattaacTgtttgttcagaagacaatgt							TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr17:29496924_29496927delTGTT	uc002hgg.2	+	5	828_831	c.495_498delTGTT	c.(493-498)ACTGTTfs	p.T165fs	NF1_uc002hge.1_Frame_Shift_Del_p.T165fs|NF1_uc002hgf.1_Frame_Shift_Del_p.T165fs|NF1_uc002hgh.2_Frame_Shift_Del_p.T165fs|NF1_uc010csn.1_Intron	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	165_166					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.C167fs*10(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGGAATTAACTGTTTGTTCAGAAG	0.225			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29496927	-	-	29496924	7	5	203	1	0	1	0	1	0	0	0	0	10356	1567	55	0	513	0	NF1	17	29496924	Frame_Shift_Del	DEL	TGTT	TCGA-28-2502-01B-01D-1494-08		29496924	51698286	51	14327											
KRT36	8689	broad.mit.edu	37	chr17	39644595	39644595	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagctcatccaggatcctaCgcaggccgttgatgtcggcc	11	14	2	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr17:39644595C>T	uc002hwt.2	-	3	599	c.599G>A	c.(598-600)CGT>CAT	p.R200H		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	200	Rod.|Coil 1B.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CAGGATCCTACGCAGGCCGTT	0.577													T	39644595	T	T	39644595	3	4	203	1	0	0	0	0	1	0	0	0	8473	536	19	1	824	1	KRT36	17	39644595	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	10147671	39644595	41550615	52	14328											
BCAS3	54828	broad.mit.edu	37	chr17	58756885	58756885	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtactggtggagttgtggttCgcccccaggctgtcacgtaa	14	10	1	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr17:58756885C>T	uc002iyv.3	+	2	176	c.67C>T	c.(67-69)CGC>TGC	p.R23C	BCAS3_uc010wow.1_Missense_Mutation_p.R19C|BCAS3_uc002iyu.3_Missense_Mutation_p.R23C|BCAS3_uc002iyw.3_Missense_Mutation_p.R19C	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	23						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			AGTTGTGGTTCGCCCCCAGGC	0.383													T	58756885	T	T	58756885	3	4	203	1	0	0	0	0	1	0	0	0	1352	884	31	2	69	2	BCAS3	17	58756885	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	19112290	58756885	22438325	53	14329											
ABCA10	10349	broad.mit.edu	37	chr17	67212489	67212489	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaagcaaatgtatgtcaatcCccaggagagcctatagtaga	10	8	1	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr17:67212489C>A	uc010dfa.1	-	8	1420	c.541G>T	c.(541-543)GGA>TGA	p.G181*	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_5'Flank|ABCA10_uc010dfc.1_Nonsense_Mutation_p.G73*	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	181					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TATGTCAATCCCCAGGAGAGC	0.328													A	67212489	A	A	67212489	4	1	203	1	0	0	0	0	0	1	0	0	29	632	22	5	4222	5	ABCA10	17	67212489	Nonsense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	8455604	67212489	13982721	54	14330											
KCNJ16	3773	broad.mit.edu	37	chr17	68128849	68128849	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcgcattggtgattttcgGccaaaccacgtggtagaagg	14	8	0	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr17:68128849G>A	uc002jin.2	+	5	1107	c.621G>A	c.(619-621)CGG>CGA	p.R207R	KCNJ16_uc002jio.2_Silent_p.R207R|KCNJ16_uc002jip.2_Silent_p.R207R|KCNJ16_uc002jiq.2_Silent_p.R239R	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	207	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					GTGATTTTCGGCCAAACCACG	0.468													A	68128849	A	A	68128849	2	1	203	1	0	0	0	0	0	0	0	1	8050	1190	42	3		3	KCNJ16	17	68128849	Silent	SNP	G	TCGA-28-2502-01B-01D-1494-08	916360	68128849	13066361	55	14331											
ZNF556	80032	broad.mit.edu	37	chr19	2877814	2877814	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcacgccggagggagaccGtatgagtgcaagcagtgtgg	17	8	0	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr19:2877814G>A	uc002lwp.1	+	4	945	c.858G>A	c.(856-858)CCG>CCA	p.P286P	ZNF556_uc002lwq.2_Silent_p.P285P	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGGAGACCGTATGAGTGCA	0.517													A	2877814	A	A	2877814	2	1	203	1	0	0	0	0	0	0	0	1	17984	1132	40	1		1	ZNF556	19	2877814	Silent	SNP	G	TCGA-28-2502-01B-01D-1494-08		2877814	56251169	56	14332											
CCDC105	126402	broad.mit.edu	37	chr19	15132710	15132710	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacgtgggcacccaactcccGgaggctgcgcgcctcgcaca	12	18	0	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr19:15132710G>A	uc002nae.2	+	6	1329	c.1230G>A	c.(1228-1230)CCG>CCA	p.P410P		NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	410					microtubule cytoskeleton organization	microtubule				ovary(1)	1						CCCAACTCCCGGAGGCTGCGC	0.632													A	15132710	A	A	15132710	2	1	203	1	0	0	0	0	0	0	0	1	2740	1103	39	2		2	CCDC105	19	15132710	Silent	SNP	G	TCGA-28-2502-01B-01D-1494-08	12254896	15132710	43996273	57	14333											
CYP4F22	126410	broad.mit.edu	37	chr19	15648391	15648391	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacaagtggagccggcaccGtcgcctgctgacacccgcct	12	16	0	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr19:15648391G>A	uc002nbh.3	+	6	634	c.467G>A	c.(466-468)CGT>CAT	p.R156H		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	156						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						AGCCGGCACCGTCGCCTGCTG	0.542													A	15648391	A	A	15648391	3	1	203	1	0	0	0	0	1	0	0	0	4189	1145	40	1	481	1	CYP4F22	19	15648391	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	515681	15648391	43480592	58	14334											
FFAR2	2867	broad.mit.edu	37	chr19	35940986	35940986	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	acaagctctcccgccggcctCtgtatggagtgattgcagct	11	13	2	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr19:35940986C>T	uc002nzg.2	+	2	450	c.370C>T	c.(370-372)CTG>TTG	p.L124L	FFAR2_uc010eea.2_Silent_p.L124L	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	124	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCGCCGGCCTCTGTATGGAGT	0.577													T	35940986	T	T	35940986	2	4	203	1	0	0	0	0	0	0	0	1	5828	912	32	3		3	FFAR2	19	35940986	Silent	SNP	C	TCGA-28-2502-01B-01D-1494-08	20292595	35940986	23187997	59	14335											
MAP4K1	11184	broad.mit.edu	37	chr19	39098515	39098515	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcacttacatgtccacgtcGtcatagtcatcgtcagacga	7	13	4	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr19:39098515G>A	uc002oix.1	-	16	1254	c.1146C>T	c.(1144-1146)GAC>GAT	p.D382D	MAP4K1_uc002oiw.1_Translation_Start_Site|MAP4K1_uc002oiy.1_Silent_p.D382D|MAP4K1_uc010xug.1_Silent_p.D44D	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	382					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGTCCACGTCGTCATAGTCAT	0.597													A	39098515	A	A	39098515	2	1	203	1	0	0	0	0	0	0	0	1	9259	1136	40	1		1	MAP4K1	19	39098515	Silent	SNP	G	TCGA-28-2502-01B-01D-1494-08	3157529	39098515	20030468	60	14336											
DMPK	1760	broad.mit.edu	37	chr19	46275974	46275974	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaagcagctgctcggcctcCagttccatgggtgtggggcc	14	13	1	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr19:46275974C>T	uc002pdd.1	-	9	1843	c.1299G>A	c.(1297-1299)CTG>CTA	p.L433L	DMPK_uc010xxs.1_Silent_p.L334L|DMPK_uc002pde.1_Silent_p.L428L|DMPK_uc002pdf.1_Silent_p.L423L|DMPK_uc002pdg.1_Silent_p.L418L|DMPK_uc002pdh.1_Silent_p.L418L|DMPK_uc002pdi.1_Silent_p.L449L|DMPK_uc010xxt.1_Silent_p.L418L	NM_001081563	NP_001075032	Q09013	DMPK_HUMAN	myotonic dystrophy protein kinase isoform 1	433					regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)	3		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		GCTCGGCCTCCAGTTCCATGG	0.627													T	46275974	T	T	46275974	2	4	203	1	0	0	0	0	0	0	0	1	4584	581	21	3		3	DMPK	19	46275974	Silent	SNP	C	TCGA-28-2502-01B-01D-1494-08	7177459	46275974	12853009	61	14337											
ZNF831	128611	broad.mit.edu	37	chr20	57766702	57766702	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcagagtccgagggcgccGggggcggcctcctggaggaa	18	13	1	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr20:57766702G>A	uc002yan.2	+	1	628	c.628G>A	c.(628-630)GGG>AGG	p.G210R		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	210						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CGAGGGCGCCGGGGGCGGCCT	0.677													A	57766702	A	A	57766702	3	1	203	1	0	0	0	0	1	0	0	0	18182	1116	39	2	630	2	ZNF831	20	57766702	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08		57766702	5258818	62	14338											
IFNGR2	3460	broad.mit.edu	37	chr21	34799266	34799266	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcaggttctcctctccctTtgacatcgctgatacctcca	5	16	3	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr21:34799266T>C	uc002yrp.3	+	4	1136	c.488T>C	c.(487-489)TTT>TCT	p.F163S	IFNGR2_uc002yrq.3_Missense_Mutation_p.F182S|IFNGR2_uc010gma.2_Missense_Mutation_p.F84S|IFNGR2_uc002yrr.3_Missense_Mutation_p.F84S	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	163	Extracellular (Potential).|Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	TCCTCTCCCTTTGACATCGCT	0.443													C	34799266	C	C	34799266	3	2	203	1	0	0	0	0	1	0	0	0	7550	1841	64	4	502	4	IFNGR2	21	34799266	Missense_Mutation	SNP	T	TCGA-28-2502-01B-01D-1494-08		34799266	13330629	63	14339											
BPIL2	254240	broad.mit.edu	37	chr22	32828360	32828360	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cactgtctccccagacttacGaagtccatggaaacgatggt	9	12	1	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr22:32828360G>A	uc003amn.2	-	10	1149	c.1149C>T	c.(1147-1149)TTC>TTT	p.F383F	BPIL2_uc010gwo.2_Intron|BPIL2_uc011amb.1_Silent_p.F107F	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	383						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						CCAGACTTACGAAGTCCATGG	0.517													A	32828360	A	A	32828360	2	1	203	1	0	0	0	0	0	0	0	1	1492	1072	37	2		2	BPIL2	22	32828360	Silent	SNP	G	TCGA-28-2502-01B-01D-1494-08		32828360	18476206	64	14340											
MYH9	4627	broad.mit.edu	37	chr22	36696181	36696181	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacgggcctcaccttggccaGcttgcagttctggtcctcca	10	16	2	0			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr22:36696181G>A	uc003apg.2	-	23	3199	c.2968C>T	c.(2968-2970)CTG>TTG	p.L990L	MYH9_uc003aph.1_Silent_p.L854L	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	990	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						ACCTTGGCCAGCTTGCAGTTC	0.662			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				A	36696181	A	A	36696181	2	1	203	1	0	0	0	0	0	0	0	1	10042	962	34	3		3	MYH9	22	36696181	Silent	SNP	G	TCGA-28-2502-01B-01D-1494-08	3867821	36696181	14608385	65	14341											
TMEM184B	25829	broad.mit.edu	37	chr22	38617546	38617546	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccactgaggctgtgggagCgggagaggccgtgggcgcca	20	11	0	2			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr22:38617546C>T	uc003avf.1	-	9	1378	c.1154G>A	c.(1153-1155)CGC>CAC	p.R385H	TMEM184B_uc003avg.1_Missense_Mutation_p.R385H|TMEM184B_uc003avh.1_Missense_Mutation_p.R319H	NM_012264	NP_036396	Q9Y519	T184B_HUMAN	transmembrane protein 184B	385						integral to membrane					0	Melanoma(58;0.045)					GCTGTGGGAGCGGGAGAGGCC	0.652													T	38617546	T	T	38617546	3	4	203	1	0	0	0	0	1	0	0	0	16102	768	27	1	73	1	TMEM184B	22	38617546	Missense_Mutation	SNP	C	TCGA-28-2502-01B-01D-1494-08	1921365	38617546	12687020	66	14342											
MEI1	150365	broad.mit.edu	37	chr22	42191460	42191460	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcctctctcatgaagaggtgGgtgatgttctgcaaggtgtg	14	7	3	3			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr22:42191460G>C	uc003baz.1	+	29	3605	c.3580G>C	c.(3580-3582)GGT>CGT	p.G1194R	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Missense_Mutation_p.G580R|MEI1_uc003bbc.1_Missense_Mutation_p.G562R|MEI1_uc010gym.1_Missense_Mutation_p.G527R|MEI1_uc003bbd.1_Intron|MEI1_uc010gyn.1_RNA|MEI1_uc003bbe.1_RNA|MEI1_uc003bbf.2_Missense_Mutation_p.G208R|MEI1_uc003bbg.2_Intron	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	1194							binding			central_nervous_system(1)|skin(1)	2						TGAAGAGGTGGGTGATGTTCT	0.557													C	42191460	C	C	42191460	3	2	203	1	0	0	0	0	1	0	0	0	9465	1232	43	5	3694	5	MEI1	22	42191460	Missense_Mutation	SNP	G	TCGA-28-2502-01B-01D-1494-08	3573914	42191460	9113106	67	14343											
PANX2	56666	broad.mit.edu	37	chr22	50617532	50617532	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaccatcctgagccgaaaCgccacacacccgctgctgca	7	19	1	1	rs145485598		TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chr22:50617532C>T	uc003bjn.3	+	3	1860	c.1860C>T	c.(1858-1860)AAC>AAT	p.N620N	PANX2_uc003bjp.3_Silent_p.N486N|PANX2_uc003bjo.3_Silent_p.N620N	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	620	Cytoplasmic (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		TGAGCCGAAACGCCACACACC	0.716													T	50617532	T	T	50617532	2	4	203	1	0	0	0	0	0	0	0	1	11421	535	19	1		1	PANX2	22	50617532	Silent	SNP	C	TCGA-28-2502-01B-01D-1494-08	8426072	50617532	687034	68	14344											
FAM47B	170062	broad.mit.edu	37	chrX	34962109	34962109	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catttttgggaatcctgtccGcggccttttgagagtcggat	12	9	0	1			TCGA-28-2502-01B-01D-1494-08	TCGA-28-2502-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	707466c8-138a-4ed0-b806-6579464595cb	cb3968fd-b397-486f-9149-1de2830947f2	g.chrX:34962109G>A	uc004ddi.1	+	1	1179	c.1161G>A	c.(1159-1161)CCG>CCA	p.P387P		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	387										ovary(3)|breast(1)	4						AATCCTGTCCGCGGCCTTTTG	0.567													A	34962109	A	A	34962109	2	1	203	1	0	0	0	0	0	0	0	1	5570	1074	38	1		1	FAM47B	23	34962109	Silent	SNP	G	TCGA-28-2502-01B-01D-1494-08		34962109	120308451	69	14345											
DARC	2532	broad.mit.edu	37	chr1	159175495	159175495	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttttcagacctctcttccGctggcagctctgccctggct	9	16	3	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr1:159175495G>A	uc001fto.2	+	2	506	c.266G>A	c.(265-267)CGC>CAC	p.R89H	DARC_uc001ftp.3_Missense_Mutation_p.R91H	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	89	Cytoplasmic (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					CCTCTCTTCCGCTGGCAGCTC	0.602													A	159175495	A	A	159175495	3	1	204	1	0	0	0	0	1	0	0	0	4240	1087	38	1	299	1	DARC	1	159175495	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08		159175495	90075126	1	14346											
OBSCN	84033	broad.mit.edu	37	chr1	228529316	228529316	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctggccctgcctgtgtggcGtgagtgtccaccttcccggg	14	14	1	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr1:228529316G>A	uc009xez.1	+	74	18078	c.18034_splice	c.e74+1	p.R6012_splice	OBSCN_uc001hsn.2_Splice_Site_p.R6012_splice|OBSCN_uc001hsr.1_Splice_Site_p.R641_splice	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCTGTGTGGCGTGAGTGTCCA	0.667													A	228529316	A	A	228529316	5	1	204	1	0	0	0	0	0	0	1	0	10812	1159	40	1	18325	1	OBSCN	1	228529316	Splice_Site	SNP	G	TCGA-28-2509-01A-01D-1494-08	69353821	228529316	20721305	2	14347											
GALNT3	2591	broad.mit.edu	37	chr2	166611230	166611230	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agacatagaggctgaccaacGcttttaatctaaaggaaaat	8	7	1	3			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr2:166611230G>A	uc010fph.1	-	9	1920	c.1533C>T	c.(1531-1533)AGC>AGT	p.S511S		NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	511	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						GCTGACCAACGCTTTTAATCT	0.303													A	166611230	A	A	166611230	2	1	204	1	0	0	0	0	0	0	0	1	6214	1078	38	1		1	GALNT3	2	166611230	Silent	SNP	G	TCGA-28-2509-01A-01D-1494-08		166611230	76588143	3	14348											
SESTD1	91404	broad.mit.edu	37	chr2	180014058	180014058	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgatttcctttatcacttcCattgttaatcaaagcaagtt	4	9	2	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr2:180014058C>A	uc002uni.3	-	7	697	c.547G>T	c.(547-549)GGA>TGA	p.G183*		NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	183					regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			TTATCACTTCCATTGTTAATC	0.308													A	180014058	A	A	180014058	4	1	204	1	0	0	0	0	0	1	0	0	14127	603	21	5	1591	5	SESTD1	2	180014058	Nonsense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	13402828	180014058	63185315	4	14349											
SP100	6672	broad.mit.edu	37	chr2	231328786	231328786	+	Frame_Shift_Del	DEL	C	-	-													ccattcttttgtgcagtgatCaataatgacaaccctttaga							TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr2:231328786delC	uc002vqt.2	+	11	1203	c.1062delC	c.(1060-1062)ATCfs	p.I354fs	SP100_uc002vqs.2_Frame_Shift_Del_p.I354fs|SP100_uc002vqu.1_Frame_Shift_Del_p.I354fs|SP100_uc002vqq.1_Frame_Shift_Del_p.I354fs|SP100_uc002vqr.1_Frame_Shift_Del_p.I329fs|SP100_uc010zmc.1_Frame_Shift_Del_p.I329fs|SP100_uc002vqv.1_Frame_Shift_Del_p.I318fs	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	354					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GTGCAGTGATCAATAATGACA	0.408													-	231328786	-	-	231328786	7	5	204	1	0	1	0	1	0	0	0	0	14960	816	29	0	1104	0	SP100	2	231328786	Frame_Shift_Del	DEL	C	TCGA-28-2509-01A-01D-1494-08	51314728	231328786	11870587	5	14350											
TRAT1	50852	broad.mit.edu	37	chr3	108572602	108572602	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacatgcaatagatgccagcGtttctaagaccaccttagta	7	10	1	2	rs142175794	byFrequency	TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr3:108572602G>A	uc003dxi.1	+	6	583	c.439G>A	c.(439-441)GTT>ATT	p.V147I	TRAT1_uc010hpx.1_Missense_Mutation_p.V110I	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	147	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						AGATGCCAGCGTTTCTAAGAC	0.458													A	108572602	A	A	108572602	3	1	204	1	0	0	0	0	1	0	0	0	16463	1145	40	1	461	1	TRAT1	3	108572602	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08		108572602	89449828	6	14351											
PARP9	83666	broad.mit.edu	37	chr3	122274913	122274913	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttattttttaaaattttgaaGtcattgtggttaatgggaat	8	1	1	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr3:122274913G>C	uc010hri.2	-	4	355	c.210C>G	c.(208-210)GAC>GAG	p.D70E	PARP9_uc003eff.3_Missense_Mutation_p.D35E|PARP9_uc011bjs.1_Missense_Mutation_p.D35E|PARP9_uc003efg.2_Intron|PARP9_uc003efi.2_Missense_Mutation_p.D35E|PARP9_uc003efh.2_Missense_Mutation_p.D70E|PARP9_uc003efj.2_Missense_Mutation_p.D35E	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	70					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		AAATTTTGAAGTCATTGTGGT	0.353													C	122274913	C	C	122274913	3	2	204	1	0	0	0	0	1	0	0	0	11466	1020	36	5	2439	5	PARP9	3	122274913	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	13702311	122274913	75747517	7	14352											
DBR1	51163	broad.mit.edu	37	chr3	137880744	137880746	+	In_Frame_Del	DEL	TCA	-	-													aatcatcttaagctgcatcgTcatcatcatcatccactgca							TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr3:137880744_137880746delTCA	uc003erv.2	-	8	1756_1758	c.1620_1622delTGA	c.(1618-1623)GATGAT>GAT	p.540_541DD>D	DBR1_uc003eru.2_In_Frame_Del_p.489_490DD>D|DBR1_uc003ert.2_In_Frame_Del_p.308_309DD>D	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	540_541						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						AGCTGCATCGTCATCATCATCAT	0.261													-	137880746	-	-	137880744	7	5	204	1	0	1	0	1	0	0	0	0	4257	1667	58	0	16	0	DBR1	3	137880744	In_Frame_Del	DEL	TCA	TCGA-28-2509-01A-01D-1494-08	15605831	137880744	60141686	8	14353											
KIT	3815	broad.mit.edu	37	chr4	55564507	55564507	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggaaagaagacaacgacaCgctggtccgctgtcctctca	11	12	1	2			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr4:55564507C>T	uc010igr.2	+	3	482	c.395C>T	c.(394-396)ACG>ATG	p.T132M	KIT_uc010igs.2_Missense_Mutation_p.T132M	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	132	Extracellular (Potential).|Ig-like C2-type 2.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GACAACGACACGCTGGTCCGC	0.498		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				T	55564507	T	T	55564507	3	4	204	1	0	0	0	0	1	0	0	0	8329	536	19	1	405	1	KIT	4	55564507	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08		55564507	135589769	9	14354											
SULT1B1	27284	broad.mit.edu	37	chr4	70592883	70592883	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcaaatttctcattttgggCcacggtgaagtaattcttcc	7	9	3	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr4:70592883C>T	uc003hen.2	-	8	1112	c.814G>A	c.(814-816)GCC>ACC	p.A272T		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	272					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						TCATTTTGGGCCACGGTGAAG	0.343													T	70592883	T	T	70592883	3	4	204	1	0	0	0	0	1	0	0	0	15373	739	26	3	80	3	SULT1B1	4	70592883	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	15028376	70592883	120561393	10	14355											
FRAS1	80144	broad.mit.edu	37	chr4	79447726	79447726	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caggagagtacaccatctacCtgatcccttgcacagtgcag	9	13	1	2			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr4:79447726C>G	uc003hlb.2	+	70	11280	c.10840C>G	c.(10840-10842)CTG>GTG	p.L3614V		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3609	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CACCATCTACCTGATCCCTTG	0.512													G	79447726	G	G	79447726	3	3	204	1	0	0	0	0	1	0	0	0	6042	680	24	5	11193	5	FRAS1	4	79447726	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	8854843	79447726	111706550	11	14356											
FAT1	2195	broad.mit.edu	37	chr4	187522529	187522529	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaatttgttttcattttccGtcagacggtatttcacgtag	7	8	3	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr4:187522529G>A	uc003izf.2	-	21	11722	c.11534C>T	c.(11533-11535)ACG>ATG	p.T3845M		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3845	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTCATTTTCCGTCAGACGGTA	0.413										HNSCC(5;0.00058)			A	187522529	A	A	187522529	3	1	204	1	0	0	0	0	1	0	0	0	5689	1145	40	1	2260	1	FAT1	4	187522529	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	108074803	187522529	3631747	12	14357											
PCDHB7	56129	broad.mit.edu	37	chr5	140553530	140553530	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tggctgtttttaggattagaGacagagattccgggaacaat	12	5	0	2			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr5:140553530G>C	uc003lit.2	+	1	1288	c.1114G>C	c.(1114-1116)GAC>CAC	p.D372H		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	372	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGGATTAGAGACAGAGATTC	0.468													C	140553530	C	C	140553530	3	2	204	1	0	0	0	0	1	0	0	0	11547	942	33	5	1116	5	PCDHB7	5	140553530	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08		140553530	40361730	13	14358											
GM2A	2760	broad.mit.edu	37	chr5	150639411	150639411	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctggagcctgaccccatcatCgttcctggaaatgtgaccct	9	14	1	2			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr5:150639411C>T	uc003ltr.3	+	2	342	c.177C>T	c.(175-177)ATC>ATT	p.I59I	GM2A_uc011dcs.1_RNA|GM2A_uc011dcr.1_Silent_p.I59I|GM2A_uc003ltt.1_5'UTR	NM_000405	NP_000396	P17900	SAP3_HUMAN	GM2 ganglioside activator precursor	59						lysosome|nucleolus	sphingolipid activator protein activity				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCCCATCATCGTTCCTGGAA	0.587													T	150639411	T	T	150639411	2	4	204	1	0	0	0	0	0	0	0	1	6484	874	31	2		2	GM2A	5	150639411	Silent	SNP	C	TCGA-28-2509-01A-01D-1494-08	10085881	150639411	30275849	14	14359											
FAT2	2196	broad.mit.edu	37	chr5	150922530	150922530	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tagactgtagatgactggatCttgagctgccactgctttaa	10	8	1	4			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr5:150922530C>G	uc003lue.3	-	9	8171	c.8158G>C	c.(8158-8160)GAT>CAT	p.D2720H	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2720	Cadherin 24.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGACTGGATCTTGAGCTGCC	0.478													G	150922530	G	G	150922530	3	3	204	1	0	0	0	0	1	0	0	0	5690	913	32	5	4951	5	FAT2	5	150922530	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	283119	150922530	29992730	15	14360											
SLIT3	6586	broad.mit.edu	37	chr5	168233574	168233574	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggagttggcattgcaggatGggggctccgagtggggggct	21	6	0	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr5:168233574G>T	uc003mab.2	-	9	1232	c.812C>A	c.(811-813)CCA>CAA	p.P271Q	SLIT3_uc010jjg.2_Missense_Mutation_p.P271Q|SLIT3_uc010jji.2_Missense_Mutation_p.P271Q|SLIT3_uc003mac.1_Missense_Mutation_p.P68Q	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	271	LRRNT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATTGCAGGATGGGGGCTCCGA	0.567													T	168233574	T	T	168233574	3	4	204	1	0	0	0	0	1	0	0	0	14741	1348	47	5	3871	5	SLIT3	5	168233574	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	17311044	168233574	12681686	16	14361											
FOXI1	2299	broad.mit.edu	37	chr5	169535115	169535115	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttcgacaatggaaatttcCgcaggaaaaggaagagaaaa	11	5	0	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr5:169535115C>T	uc003mai.3	+	2	682	c.637C>T	c.(637-639)CGC>TGC	p.R213C	FOXI1_uc003maj.3_Intron	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	213	Fork-head.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGAAATTTCCGCAGGAAAAG	0.488									Pendred_syndrome				T	169535115	T	T	169535115	3	4	204	1	0	0	0	0	1	0	0	0	6009	652	23	2	643	2	FOXI1	5	169535115	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	1301541	169535115	11380145	17	14362											
ARID1B	57492	broad.mit.edu	37	chr6	157495209	157495209	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccctgcctctcaaagcagaCggcaaagaagaaggcactcc	9	15	1	3	rs147853607		TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr6:157495209C>T	uc003qqn.2	+	10	3032	c.2880C>T	c.(2878-2880)GAC>GAT	p.D960D	ARID1B_uc003qqo.2_Silent_p.D973D|ARID1B_uc003qqp.2_Silent_p.D960D|ARID1B_uc010kjl.2_Silent_p.D158D	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TCAAAGCAGACGGCAAAGAAG	0.507													T	157495209	T	T	157495209	2	4	204	1	0	0	0	0	0	0	0	1	914	535	19	1		1	ARID1B	6	157495209	Silent	SNP	C	TCGA-28-2509-01A-01D-1494-08		157495209	13619858	18	14363											
GCC1	79571	broad.mit.edu	37	chr7	127222986	127222986	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtagccttctccccatcagcAgcctccgagctgggcattat	9	15	2	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr7:127222986A>G	uc003vma.2	-	2	1828	c.1410T>C	c.(1408-1410)GCT>GCC	p.A470A		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	470	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						CCCCATCAGCAGCCTCCGAGC	0.542													G	127222986	G	G	127222986	2	3	204	1	0	0	0	0	0	0	0	1	6285	175	7	4		4	GCC1	7	127222986	Silent	SNP	A	TCGA-28-2509-01A-01D-1494-08		127222986	31915677	19	14364											
OR2A25	392138	broad.mit.edu	37	chr7	143771552	143771552	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagcacggtgccccagatGctggtgaacctcctgcatcc	11	15	0	2			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr7:143771552G>A	uc011ktx.1	+	1	240	c.240G>A	c.(238-240)ATG>ATA	p.M80I		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TGCCCCAGATGCTGGTGAACC	0.547													A	143771552	A	A	143771552	3	1	204	1	0	0	0	0	1	0	0	0	10978	1319	46	3	242	3	OR2A25	7	143771552	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	16548566	143771552	15367111	20	14365											
ABCB8	11194	broad.mit.edu	37	chr7	150737710	150737710	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggctccgttacatttcagaaCgtctgcttcaggtcagcacg	10	12	4	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr7:150737710C>G	uc003wil.3	+	12	1521	c.1428C>G	c.(1426-1428)AAC>AAG	p.N476K	ABCB8_uc010lpw.1_Missense_Mutation_p.N348K|ABCB8_uc010lpx.2_Missense_Mutation_p.N459K|ABCB8_uc011kvd.1_Missense_Mutation_p.N371K|ABCB8_uc003wim.3_Missense_Mutation_p.N254K|ABCB8_uc003wik.3_Missense_Mutation_p.N459K	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	476	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATTTCAGAACGTCTGCTTCA	0.632													G	150737710	G	G	150737710	3	3	204	1	0	0	0	0	1	0	0	0	47	535	19	5	1419	5	ABCB8	7	150737710	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	6966158	150737710	8400953	21	14366											
SGK223	157285	broad.mit.edu	37	chr8	8235473	8235473	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacagcgagaattgccatcaGgggaggtagagggaccagca	16	8	1	2			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr8:8235473G>T	uc003wsh.3	-	2	446	c.446C>A	c.(445-447)CCT>CAT	p.P149H		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	149							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						ATTGCCATCAGGGGAGGTAGA	0.642													T	8235473	T	T	8235473	3	4	204	1	0	0	0	0	1	0	0	0	14210	1000	35	5	3778	5	SGK223	8	8235473	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08		8235473	138128549	22	14367											
PRKDC	5591	broad.mit.edu	37	chr8	48869810	48869810	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaaactttaggatttcttctCtacattcacgaaactgtaat	4	8	3	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr8:48869810C>T	uc003xqi.2	-	3	302	c.245G>A	c.(244-246)AGA>AAA	p.R82K	PRKDC_uc003xqj.2_Missense_Mutation_p.R82K|PRKDC_uc011ldh.1_Missense_Mutation_p.R82K	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	82					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GATTTCTTCTCTACATTCACG	0.318								NHEJ					T	48869810	T	T	48869810	3	4	204	1	0	0	0	0	1	0	0	0	12521	913	32	3	12476	3	PRKDC	8	48869810	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	40634337	48869810	97494212	23	14368											
TSNARE1	203062	broad.mit.edu	37	chr8	143425640	143425640	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgtgccaaacagcagctgGtggtgcttgctcaccttgga	12	13	1	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr8:143425640G>A	uc003ywk.2	-	4	550	c.432C>T	c.(430-432)CAC>CAT	p.H144H	TSNARE1_uc011lju.1_Silent_p.H144H|TSNARE1_uc003ywj.2_Silent_p.H144H|TSNARE1_uc003ywl.3_Intron	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	144					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					ACAGCAGCTGGTGGTGCTTGC	0.667													A	143425640	A	A	143425640	2	1	204	1	0	0	0	0	0	0	0	1	16627	1252	44	3		3	TSNARE1	8	143425640	Silent	SNP	G	TCGA-28-2509-01A-01D-1494-08	94555830	143425640	2938382	24	14369											
ZNF658	26149	broad.mit.edu	37	chr9	40772759	40772759	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgatgtgcacagaggtgtGttctttgggagaaagttttc	13	5	2	3			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr9:40772759G>A	uc004abs.2	-	5	2668	c.2516C>T	c.(2515-2517)ACA>ATA	p.T839I	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.T839I	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	839	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACAGAGGTGTGTTCTTTGGGA	0.428													A	40772759	A	A	40772759	3	1	204	1	0	0	0	0	1	0	0	0	18066	1377	48	3	667	3	ZNF658	9	40772759	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08		40772759	100440672	25	14370											
C9orf140	89958	broad.mit.edu	37	chr9	139959203	139959203	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gagcgccgacttctcctgctCcagctgcgtgatgcgctcac	11	16	2	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr9:139959203C>T	uc011men.1	-	6	1209	c.1093G>A	c.(1093-1095)GAG>AAG	p.E365K		NM_178448	NP_848543	Q86UD0	CI140_HUMAN	tumor specificity and mitosis phase-dependent	365	Potential.					cytoplasm|nucleus				skin(1)	1	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;3.02e-05)|Epithelial(140;0.000499)		TTCTCCTGCTCCAGCTGCGTG	0.647											OREG0019628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	139959203	T	T	139959203	3	4	204	1	0	0	0	0	1	0	0	0	2460	864	30	3	95	3	C9orf140	9	139959203	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	99186444	139959203	1254228	26	14371											
AGAP6	414189	broad.mit.edu	37	chr10	51748567	51748567	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtccctctgaatctgagaCctatgaggcaggagctaggg	14	9	2	3			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr10:51748567C>T	uc001jix.3	+	1	490	c.92C>T	c.(91-93)ACC>ATC	p.T31I		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	31					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						GAATCTGAGACCTATGAGGCA	0.597													T	51748567	T	T	51748567	3	4	204	1	0	0	0	0	1	0	0	0	372	507	18	3	94	3	AGAP6	10	51748567	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08		51748567	83786180	27	14372											
VENTX	27287	broad.mit.edu	37	chr10	135053299	135053299	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtacctgagccctctggagCggaagaggctggccagggag	17	10	1	2			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr10:135053299C>T	uc010quy.1	+	2	372	c.361C>T	c.(361-363)CGG>TGG	p.R121W		NM_014468	NP_055283	O95231	VENTX_HUMAN	VENT homeobox	121	Homeobox.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		CCCTCTGGAGCGGAAGAGGCT	0.488													T	135053299	T	T	135053299	3	4	204	1	0	0	0	0	1	0	0	0	17150	759	27	1	367	1	VENTX	10	135053299	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	83304732	135053299	481448	28	14373											
OR4C3	256144	broad.mit.edu	37	chr11	48346680	48346680	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgctgatctatgtggtcaCggtttgtggcaacatgctca	11	8	3	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr11:48346680C>T	uc010rhv.1	+	1	188	c.188C>T	c.(187-189)ACG>ATG	p.T63M		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TATGTGGTCACGGTTTGTGGC	0.463													T	48346680	T	T	48346680	3	4	204	1	0	0	0	0	1	0	0	0	11050	536	19	1	190	1	OR4C3	11	48346680	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08		48346680	86659836	29	14374											
OR4A47	403253	broad.mit.edu	37	chr11	48510660	48510660	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctttatcgagcacattttcGgtgggtcagaggtctttctc	10	9	4	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr11:48510660G>A	uc010rhx.1	+	1	316	c.316G>A	c.(316-318)GGT>AGT	p.G106S		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GCACATTTTCGGTGGGTCAGA	0.453													A	48510660	A	A	48510660	3	1	204	1	0	0	0	0	1	0	0	0	11042	1116	39	2	318	2	OR4A47	11	48510660	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	163980	48510660	86495856	30	14375											
OR5W2	390148	broad.mit.edu	37	chr11	55681751	55681751	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatctgcaaagatacagaagAccaagaattgcagagcacag	9	8	1	5			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr11:55681751A>G	uc010rir.1	-	1	308	c.308T>C	c.(307-309)GTC>GCC	p.V103A		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GATACAGAAGACCAAGAATTG	0.468													G	55681751	G	G	55681751	3	3	204	1	0	0	0	0	1	0	0	0	11185	275	10	4	626	4	OR5W2	11	55681751	Missense_Mutation	SNP	A	TCGA-28-2509-01A-01D-1494-08	7171091	55681751	79324765	31	14376											
GANAB	23193	broad.mit.edu	37	chr11	62400735	62400735	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttctctgccttcccctgagtCtcctctggctgttaagaaga	8	13	3	3			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr11:62400735C>T	uc001nub.2	-	7	672	c.639G>A	c.(637-639)GAG>GAA	p.E213E	GANAB_uc001nua.2_Silent_p.E235E|GANAB_uc001nuc.2_Silent_p.E116E|GANAB_uc010rma.1_Silent_p.E121E|GANAB_uc010rmb.1_Silent_p.E99E	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	213					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						TCCCCTGAGTCTCCTCTGGCT	0.527													T	62400735	T	T	62400735	2	4	204	1	0	0	0	0	0	0	0	1	6233	912	32	3		3	GANAB	11	62400735	Silent	SNP	C	TCGA-28-2509-01A-01D-1494-08	6718984	62400735	72605781	32	14377											
USP28	57646	broad.mit.edu	37	chr11	113672259	113672259	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttctcatgacctcaatggCatccagatcatccttggaaa	7	11	3	2			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr11:113672259C>T	uc001poh.2	-	24	3037	c.3004G>A	c.(3004-3006)GCC>ACC	p.A1002T	USP28_uc001pog.2_Missense_Mutation_p.A678T|USP28_uc010rwy.1_Missense_Mutation_p.A845T|USP28_uc001poi.2_Missense_Mutation_p.A325T	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	1002					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		ACCTCAATGGCATCCAGATCA	0.393													T	113672259	T	T	113672259	3	4	204	1	0	0	0	0	1	0	0	0	17055	710	25	3	237	3	USP28	11	113672259	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	51271524	113672259	21334257	33	14378											
DDX25	29118	broad.mit.edu	37	chr11	125788549	125788549	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaaacgctaagtggttgacCgtggagatgatacaggatgg	15	6	0	3			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr11:125788549C>T	uc001qcz.3	+	10	1206	c.1065C>T	c.(1063-1065)ACC>ACT	p.T355T	DDX25_uc010sbk.1_Silent_p.T355T	NM_013264	NP_037396	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 25	355	Helicase C-terminal.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(1)	1	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		AGTGGTTGACCGTGGAGATGA	0.512													T	125788549	T	T	125788549	2	4	204	1	0	0	0	0	0	0	0	1	4352	639	23	2		2	DDX25	11	125788549	Silent	SNP	C	TCGA-28-2509-01A-01D-1494-08	12116290	125788549	9217967	34	14379											
LRRK2	120892	broad.mit.edu	37	chr12	40618993	40618996	+	Frame_Shift_Del	DEL	AGTC	-	-													gaaactctgaagaagttgatAgtcaggctgaacaatgtcca							TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr12:40618993_40618996delAGTC	uc001rmg.3	+	1	181_184	c.60_63delAGTC	c.(58-63)ATAGTCfs	p.I20fs		NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	20_21					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGAAGTTGATAGTCAGGCTGAACA	0.544													-	40618996	-	-	40618993	7	5	204	1	0	1	0	1	0	0	0	0	9033	410	15	0	62	0	LRRK2	12	40618993	Frame_Shift_Del	DEL	AGTC	TCGA-28-2509-01A-01D-1494-08		40618993	93232902	35	14380											
PTPRB	5787	broad.mit.edu	37	chr12	70928634	70928634	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgcatatcttaaactcccgGatggtccactcaggcaggac	9	14	2	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr12:70928634G>A	uc001swb.3	-	28	5559	c.5529C>T	c.(5527-5529)ATC>ATT	p.I1843I	uc001svz.2_Intron|PTPRB_uc010sto.1_Silent_p.I1753I|PTPRB_uc010stp.1_Silent_p.I1753I|PTPRB_uc001swc.3_Silent_p.I2061I|PTPRB_uc001swa.3_Silent_p.I1973I	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1843	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TAAACTCCCGGATGGTCCACT	0.512													A	70928634	A	A	70928634	2	1	204	1	0	0	0	0	0	0	0	1	12796	1164	41	3		3	PTPRB	12	70928634	Silent	SNP	G	TCGA-28-2509-01A-01D-1494-08	30309641	70928634	62923261	36	14381											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100451481	100451482	+	Frame_Shift_Del	DEL	AG	-	-													catattcttataagaaacacAgagaggagccaggttgggtg							TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr12:100451481_100451482delAG	uc001tgq.2	-	15	3520_3521	c.3291_3292delCT	c.(3289-3294)CTCTGTfs	p.L1097fs	UHRF1BP1L_uc001tgp.2_Frame_Shift_Del_p.L747fs	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	1097_1098										ovary(2)	2						TAAGAAACACAGAGAGGAGCCA	0.332													-	100451482	-	-	100451481	7	5	204	1	0	1	0	1	0	0	0	0	16966	188	7	0	1130	0	UHRF1BP1L	12	100451481	Frame_Shift_Del	DEL	AG	TCGA-28-2509-01A-01D-1494-08	29522847	100451481	33400414	37	14382											
SLC24A6	80024	broad.mit.edu	37	chr12	113737741	113737741	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgaggctgagccccagggcGcctgccaggacccacaccag	13	17	0	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr12:113737741G>A	uc001tvc.2	-	16	1806	c.1596C>T	c.(1594-1596)GGC>GGT	p.G532G	SLC24A6_uc001tuz.2_Silent_p.G237G|SLC24A6_uc001tva.2_RNA|SLC24A6_uc001tvb.2_Silent_p.G270G	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	532	Helical; Name=12; (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						GCCCCAGGGCGCCTGCCAGGA	0.627													A	113737741	A	A	113737741	2	1	204	1	0	0	0	0	0	0	0	1	14470	1074	38	1		1	SLC24A6	12	113737741	Silent	SNP	G	TCGA-28-2509-01A-01D-1494-08	13286260	113737741	20114154	38	14383											
KSR2	283455	broad.mit.edu	37	chr12	118105354	118105354	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtcccacaaagaaggagcGgagggagcgctcggacagca	16	10	0	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr12:118105354G>A	uc001two.2	-	5	1064	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	366					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAGAAGGAGCGGAGGGAGCGC	0.602													A	118105354	A	A	118105354	3	1	204	1	0	0	0	0	1	0	0	0	8582	1116	39	2	1820	2	KSR2	12	118105354	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	4367613	118105354	15746541	39	14384											
GCN1L1	10985	broad.mit.edu	37	chr12	120628101	120628101	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtggatgaaaaataaatacCttttccagcaacacacttcc	5	10	0	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr12:120628101C>T	uc001txo.2	-	2	134	c.121G>A	c.(121-123)GAT>AAT	p.D41N		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	41					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAATAAATACCTTTTCCAGCA	0.303													T	120628101	T	T	120628101	3	4	204	1	0	0	0	0	1	0	0	0	6299	695	24	3	8122	3	GCN1L1	12	120628101	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	2522747	120628101	13223794	40	14385											
NEK3	4752	broad.mit.edu	37	chr13	52728302	52728302	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctagaattctgtgtattagAgaaagactagaaaaacattt	7	5	1	4			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr13:52728302A>G	uc001vgi.2	-	3	359	c.124T>C	c.(124-126)TCT>CCT	p.S42P	NEK3_uc001vgg.2_Intron|NEK3_uc001vgh.2_Missense_Mutation_p.S63P|NEK3_uc010tgx.1_RNA|NEK3_uc010tgy.1_Missense_Mutation_p.S42P	NM_152720	NP_689933	P51956	NEK3_HUMAN	NIMA-related kinase 3 isoform a	42	Interaction with VAV2.|Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		TGTGTATTAGAGAAAGACTAG	0.284													G	52728302	G	G	52728302	3	3	204	1	0	0	0	0	1	0	0	0	10325	304	11	4	1452	4	NEK3	13	52728302	Missense_Mutation	SNP	A	TCGA-28-2509-01A-01D-1494-08		52728302	62441576	41	14386											
RIN3	79890	broad.mit.edu	37	chr14	93022210	93022210	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgccggggcatcagcatcctGgagaagctcatcaaaacatg	11	12	3	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr14:93022210G>A	uc001yap.2	+	2	311	c.159G>A	c.(157-159)CTG>CTA	p.L53L	RIN3_uc010auk.2_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	53					endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				TCAGCATCCTGGAGAAGCTCA	0.612													A	93022210	A	A	93022210	2	1	204	1	0	0	0	0	0	0	0	1	13373	1335	47	3		3	RIN3	14	93022210	Silent	SNP	G	TCGA-28-2509-01A-01D-1494-08		93022210	14327330	42	14387											
TJP1	7082	broad.mit.edu	37	chr15	30053400	30053400	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcagaaggctctgaccgctGgtcaggagatcgtgaccggc	14	11	3	4			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr15:30053400G>A	uc001zcr.2	-	8	1427	c.952C>T	c.(952-954)CAG>TAG	p.Q318*	TJP1_uc010azl.2_Nonsense_Mutation_p.Q306*|TJP1_uc001zcq.2_Nonsense_Mutation_p.Q322*|TJP1_uc001zcs.2_Nonsense_Mutation_p.Q318*	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	318					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TCTGACCGCTGGTCAGGAGAT	0.488													A	30053400	A	A	30053400	4	1	204	1	0	0	0	0	0	1	0	0	15926	1357	47	3	4378	3	TJP1	15	30053400	Nonsense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08		30053400	72477992	43	14388											
MAPKBP1	23005	broad.mit.edu	37	chr15	42067489	42067489	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcataatggctgtggaagggTcaaccattaccagccggatc	11	10	2	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr15:42067489T>G	uc001zok.3	+	2	302	c.16T>G	c.(16-18)TCA>GCA	p.S6A	MAPKBP1_uc001zoj.3_Missense_Mutation_p.S6A|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.S6A|MAPKBP1_uc010udb.1_5'UTR|MAPKBP1_uc010bck.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	6										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TGTGGAAGGGTCAACCATTAC	0.557													G	42067489	G	G	42067489	3	3	204	1	0	0	0	0	1	0	0	0	9292	1667	58	5	18	5	MAPKBP1	15	42067489	Missense_Mutation	SNP	T	TCGA-28-2509-01A-01D-1494-08	12014089	42067489	60463903	44	14389											
SEMA7A	8482	broad.mit.edu	37	chr15	74708161	74708161	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggggttggagaaaacacCatagaccctggtgtccctcc	11	13	0	2			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr15:74708161C>T	uc002axv.2	-	8	1007	c.967G>A	c.(967-969)GGT>AGT	p.G323S	SEMA7A_uc010ulk.1_Missense_Mutation_p.G158S|SEMA7A_uc010ull.1_Missense_Mutation_p.G309S	NM_003612	NP_003603	O75326	SEM7A_HUMAN	semaphorin 7A isoform 1 preproprotein	323	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(1)|central_nervous_system(1)	2						GAGAAAACACCATAGACCCTG	0.612													T	74708161	T	T	74708161	3	4	204	1	0	0	0	0	1	0	0	0	14043	594	21	3	1061	3	SEMA7A	15	74708161	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	32640672	74708161	27823231	45	14390											
FBXO22	26263	broad.mit.edu	37	chr15	76196838	76196838	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgcgtcctcagcgtgtgCcgcttatggagggagtgtgt	16	8	1	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr15:76196838C>T	uc002bbk.2	+	2	252	c.147C>T	c.(145-147)TGC>TGT	p.C49C	FBXO22_uc002bbj.1_Silent_p.C49C|FBXO22_uc002bbl.2_Intron	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	F-box only protein 22 isoform a	49	F-box.				ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity				0						TCAGCGTGTGCCGCTTATGGA	0.622													T	76196838	T	T	76196838	2	4	204	1	0	0	0	0	0	0	0	1	5734	747	26	3		3	FBXO22	15	76196838	Silent	SNP	C	TCGA-28-2509-01A-01D-1494-08	1488677	76196838	26334554	46	14391											
ZNF174	7727	broad.mit.edu	37	chr16	3458790	3458790	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtggaaactgctttgggcgGcagtcaaccctgaagctgca	13	10	1	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr16:3458790G>A	uc002cvc.2	+	3	1910	c.1095G>A	c.(1093-1095)CGG>CGA	p.R365R		NM_003450	NP_003441	Q15697	ZN174_HUMAN	zinc finger protein 174 isoform a	365	C2H2-type 2.				negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0						GCTTTGGGCGGCAGTCAACCC	0.542													A	3458790	A	A	3458790	2	1	204	1	0	0	0	0	0	0	0	1	17741	1190	42	3		3	ZNF174	16	3458790	Silent	SNP	G	TCGA-28-2509-01A-01D-1494-08		3458790	86895963	47	14392											
DNAH3	55567	broad.mit.edu	37	chr16	21080833	21080833	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcctctgaactgaagattGgttccaggtacagccaggtg	12	9	1	3			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr16:21080833G>A	uc010vbe.1	-	23	3284	c.3284C>T	c.(3283-3285)CCA>CTA	p.P1095L		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1095	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ACTGAAGATTGGTTCCAGGTA	0.438													A	21080833	A	A	21080833	3	1	204	1	0	0	0	0	1	0	0	0	4603	1348	47	3	9225	3	DNAH3	16	21080833	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	17622043	21080833	69273920	48	14393											
SRCAP	10847	broad.mit.edu	37	chr16	30734359	30734359	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccctcgggatggactgactcCtgttcctccattggccccag	10	16	0	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr16:30734359C>G	uc002dze.1	+	24	4353	c.3968C>G	c.(3967-3969)CCT>CGT	p.P1323R	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.P1118R|SRCAP_uc010bzz.1_Missense_Mutation_p.P893R	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1323	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GGACTGACTCCTGTTCCTCCA	0.587													G	30734359	G	G	30734359	3	3	204	1	0	0	0	0	1	0	0	0	15134	681	24	5	4054	5	SRCAP	16	30734359	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	9653526	30734359	59620394	49	14394											
SRCAP	10847	broad.mit.edu	37	chr16	30749342	30749342	+	Frame_Shift_Del	DEL	G	-	-													tcccaccctcagcagcatctGatgagccacttcaggagcca							TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr16:30749342delG	uc002dze.1	+	34	8366	c.7981delG	c.(7981-7983)GATfs	p.D2661fs	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Frame_Shift_Del_p.D2456fs	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2661	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AGCAGCATCTGATGAGCCACT	0.602													-	30749342	-	-	30749342	7	5	204	1	0	1	0	1	0	0	0	0	15134	1290	45	0	8107	0	SRCAP	16	30749342	Frame_Shift_Del	DEL	G	TCGA-28-2509-01A-01D-1494-08	14983	30749342	59605411	50	14395											
RLTPR	146206	broad.mit.edu	37	chr16	67683468	67683468	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcagcggcaacgccatggGggacgcgggcgccaagttgc	16	12	1	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr16:67683468G>A	uc002etn.2	+	20	1985	c.1865G>A	c.(1864-1866)GGG>GAG	p.G622E	RLTPR_uc010cel.1_Missense_Mutation_p.G615E|RLTPR_uc010vjr.1_Missense_Mutation_p.G586E	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	622	Tropomodulin-like.|LRR 14.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		AACGCCATGGGGGACGCGGGC	0.701													A	67683468	A	A	67683468	3	1	204	1	0	0	0	0	1	0	0	0	13394	1232	43	3	1943	3	RLTPR	16	67683468	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	36934126	67683468	22671285	51	14396											
TP53	7157	broad.mit.edu	37	chr17	7577556	7577556	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccggttcatgccgcccatgCaggaactgttacacatgtag	10	12	1	0	rs121912655		TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr17:7577556C>T	uc002gim.2	-	7	919	c.725G>A	c.(724-726)TGC>TAC	p.C242Y	TP53_uc002gig.1_Missense_Mutation_p.C242Y|TP53_uc002gih.2_Missense_Mutation_p.C242Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110Y|TP53_uc010cng.1_Missense_Mutation_p.C110Y|TP53_uc002gii.1_Missense_Mutation_p.C110Y|TP53_uc010cnh.1_Missense_Mutation_p.C242Y|TP53_uc010cni.1_Missense_Mutation_p.C242Y|TP53_uc002gij.2_Missense_Mutation_p.C242Y|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149Y|TP53_uc002gio.2_Missense_Mutation_p.C110Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGCCCATGCAGGAACTGTT	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577556	T	T	7577556	3	4	204	1	0	0	0	0	1	0	0	0	16378	710	25	3	565	3	TP53	17	7577556	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08		7577556	73617654	52	14397											
MYH8	4626	broad.mit.edu	37	chr17	10304743	10304743	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caatggtttcatccaggcctGccatctcttctgtaagattt	7	11	3	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr17:10304743G>A	uc002gmm.2	-	24	3052	c.2957C>T	c.(2956-2958)GCA>GTA	p.A986V	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	986	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATCCAGGCCTGCCATCTCTTC	0.443									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				A	10304743	A	A	10304743	3	1	204	1	0	0	0	0	1	0	0	0	10041	1319	46	3	2924	3	MYH8	17	10304743	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	2727187	10304743	70890467	53	14398											
CNDP1	84735	broad.mit.edu	37	chr18	72226676	72226676	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcagcgcctgggggcccGtgtggcctcggtggacatgg	19	12	0	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr18:72226676G>A	uc002llq.2	+	3	483	c.272G>A	c.(271-273)CGT>CAT	p.R91H	uc002llr.2_RNA	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	91					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		CTGGGGGCCCGTGTGGCCTCG	0.632													A	72226676	A	A	72226676	3	1	204	1	0	0	0	0	1	0	0	0	3593	1145	40	1	282	1	CNDP1	18	72226676	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08		72226676	5850572	54	14399											
TMEM146	257062	broad.mit.edu	37	chr19	5776309	5776309	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tatgtcttctacatttcgatCgtggatccgtactacaggtg	9	9	2	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr19:5776309C>T	uc002mda.2	+	21	2140	c.2079C>T	c.(2077-2079)ATC>ATT	p.I693I		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	693	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACATTTCGATCGTGGATCCGT	0.582													T	5776309	T	T	5776309	2	4	204	1	0	0	0	0	0	0	0	1	16057	874	31	2		2	TMEM146	19	5776309	Silent	SNP	C	TCGA-28-2509-01A-01D-1494-08		5776309	53352674	55	14400											
MUC16	94025	broad.mit.edu	37	chr19	9090864	9090864	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgggcattgtgctggctctGgcctcgggcaccccaggaga	15	12	1	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr19:9090864G>A	uc002mkp.2	-	1	1155	c.951C>T	c.(949-951)GCC>GCT	p.A317A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	317	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGCTGGCTCTGGCCTCGGGCA	0.498													A	9090864	A	A	9090864	2	1	204	1	0	0	0	0	0	0	0	1	9973	1335	47	3		3	MUC16	19	9090864	Silent	SNP	G	TCGA-28-2509-01A-01D-1494-08	3314555	9090864	50038119	56	14401											
MAST1	22983	broad.mit.edu	37	chr19	12979571	12979571	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggcaccagcagatgtcagGggatgtggcagtagagaaga	17	7	1	3			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr19:12979571G>A	uc002mvm.2	+	21	2809	c.2681G>A	c.(2680-2682)GGG>GAG	p.G894E		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	894					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CAGATGTCAGGGGATGTGGCA	0.577													A	12979571	A	A	12979571	3	1	204	1	0	0	0	0	1	0	0	0	9324	1232	43	3	2763	3	MAST1	19	12979571	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	3888707	12979571	46149412	57	14402											
ZNF626	199777	broad.mit.edu	37	chr19	20808078	20808078	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctttgccacattcttcacatTtgtagggtttccctccagta	6	12	2	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr19:20808078T>A	uc002npb.1	-	4	755	c.605A>T	c.(604-606)AAA>ATA	p.K202I	ZNF626_uc002npc.1_Missense_Mutation_p.K126I	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	202	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTCTTCACATTTGTAGGGTTT	0.368													A	20808078	A	A	20808078	3	1	204	1	0	0	0	0	1	0	0	0	18047	1841	64	5	985	5	ZNF626	19	20808078	Missense_Mutation	SNP	T	TCGA-28-2509-01A-01D-1494-08	7828507	20808078	38320905	58	14403											
FKRP	79147	broad.mit.edu	37	chr19	47258817	47258817	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctaggaattcccgggcccGggggccccgtcgtgcctctg	15	16	1	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr19:47258817G>A	uc002pfn.2	+	4	407	c.110G>A	c.(109-111)CGG>CAG	p.R37Q	FKRP_uc002pfp.2_Missense_Mutation_p.R37Q	NM_024301	NP_077277	Q9H9S5	FKRP_HUMAN	fukutin-related protein	37						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			pancreas(1)	1		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		TCCCGGGCCCGGGGGCCCCGT	0.677													A	47258817	A	A	47258817	3	1	204	1	0	0	0	0	1	0	0	0	5917	1116	39	2	112	2	FKRP	19	47258817	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	26450739	47258817	11870166	59	14404											
LILRB3	11025	broad.mit.edu	37	chr19	54724484	54724484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtagcacctgtaggtccccGcgtgggctgaggtcacagga	15	12	1	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr19:54724484G>A	uc002qef.1	-	6	1283	c.1172C>T	c.(1171-1173)GCG>GTG	p.A391V	LILRB3_uc002qee.1_Missense_Mutation_p.A391V|LILRB3_uc002qeh.1_Missense_Mutation_p.A391V|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Missense_Mutation_p.A391V|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Missense_Mutation_p.A391V|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Missense_Mutation_p.A391V|LILRB3_uc002qep.1_Missense_Mutation_p.A391V|LILRB3_uc002qeq.1_Missense_Mutation_p.A391V|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.A391V|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	391	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTAGGTCCCCGCGTGGGCTGA	0.607													A	54724484	A	A	54724484	3	1	204	1	0	0	0	0	1	0	0	0	8792	1087	38	1	758	1	LILRB3	19	54724484	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	7465667	54724484	4404499	60	14405											
LILRA6	79168	broad.mit.edu	37	chr19	54744236	54744236	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtagcacctgtaggtccccGcgtgggctgaggtcacagga	15	12	1	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr19:54744236G>A	uc002qeu.1	-	6	1296	c.1172C>T	c.(1171-1173)GCG>GTG	p.A391V	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Missense_Mutation_p.A391V|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.A391V|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Missense_Mutation_p.A391V|LILRA6_uc010yeq.1_Missense_Mutation_p.A391V|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.A252V	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	391	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTAGGTCCCCGCGTGGGCTGA	0.592													A	54744236	A	A	54744236	3	1	204	1	0	0	0	0	1	0	0	0	8789	1087	38	1	285	1	LILRA6	19	54744236	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	19752	54744236	4384747	61	14406											
ERG	2078	broad.mit.edu	37	chr21	39764312	39764312	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtacctttcgactggggcGtggggtggccgtgaccggtc	17	11	0	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chr21:39764312G>A	uc010gnw.2	-	9	1116	c.821C>T	c.(820-822)ACG>ATG	p.T274M	ERG_uc002yxa.2_Missense_Mutation_p.T267M|ERG_uc011aek.1_Missense_Mutation_p.T175M|ERG_uc010gnv.2_Missense_Mutation_p.T151M|ERG_uc010gnx.2_Missense_Mutation_p.T250M|ERG_uc011ael.1_Missense_Mutation_p.T274M|ERG_uc002yxb.2_Missense_Mutation_p.T250M|ERG_uc011aem.1_Missense_Mutation_p.T148M|ERG_uc010gny.1_RNA	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	274					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CGACTGGGGCGTGGGGTGGCC	0.448													A	39764312	A	A	39764312	3	1	204	1	0	0	0	0	1	0	0	0	5222	1145	40	1	655	1	ERG	21	39764312	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08		39764312	8365583	62	14407											
HCCS	3052	broad.mit.edu	37	chrX	11139917	11139917	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgaaagtcgcttggtggcGttggacctcgtaaagcactg	13	8	0	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:11139917G>A	uc004cuk.2	+	7	1060	c.794G>A	c.(793-795)CGT>CAT	p.R265H	HCCS_uc004cuj.2_Missense_Mutation_p.R265H|HCCS_uc004cul.1_Missense_Mutation_p.R265H	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	265					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						GCTTGGTGGCGTTGGACCTCG	0.428													A	11139917	A	A	11139917	3	1	204	1	0	0	0	0	1	0	0	0	6990	1145	40	1	816	1	HCCS	23	11139917	Missense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08		11139917	144130643	63	14408											
MAGEB6	158809	broad.mit.edu	37	chrX	26212632	26212632	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaaggcagacatgctgaaGtgtgtccgcagagagtacaa	13	7	0	4	rs141448892		TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:26212632G>A	uc004dbr.2	+	2	818	c.669G>A	c.(667-669)AAG>AAA	p.K223K	MAGEB6_uc010ngc.1_Silent_p.K3K	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	223	MAGE.									ovary(3)	3						ACATGCTGAAGTGTGTCCGCA	0.463													A	26212632	A	A	26212632	2	1	204	1	0	0	0	0	0	0	0	1	9179	1020	36	3		3	MAGEB6	23	26212632	Silent	SNP	G	TCGA-28-2509-01A-01D-1494-08	15072715	26212632	129057928	64	14409											
CXorf22	170063	broad.mit.edu	37	chrX	35985763	35985763	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccttcgatccgtaatcccaCgggaaagtttgtggtcaaag	11	10	1	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:35985763C>T	uc004ddj.2	+	10	1687	c.1628C>T	c.(1627-1629)ACG>ATG	p.T543M	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	543										large_intestine(1)|lung(1)|ovary(1)	3						CGTAATCCCACGGGAAAGTTT	0.353													T	35985763	T	T	35985763	3	4	204	1	0	0	0	0	1	0	0	0	4102	536	19	1	1666	1	CXorf22	23	35985763	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	9773131	35985763	119284797	65	14410											
ZNF157	7712	broad.mit.edu	37	chrX	47272290	47272290	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactcacacaggggagaaacCctatgaatgtagtgaatgtg	11	7	1	3			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:47272290C>T	uc004dhr.1	+	4	887	c.818C>T	c.(817-819)CCC>CTC	p.P273L		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	273					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGGGAGAAACCCTATGAATGT	0.448													T	47272290	T	T	47272290	3	4	204	1	0	0	0	0	1	0	0	0	17734	623	22	3	832	3	ZNF157	23	47272290	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	11286527	47272290	107998270	66	14411											
MORF4L2	9643	broad.mit.edu	37	chrX	102931771	102931771	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggggggttctctgcagagCgaccaccccatcttcctggg	13	13	2	1			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:102931771C>T	uc004ekw.2	-	4	1417	c.185G>A	c.(184-186)CGC>CAC	p.R62H	MORF4L2_uc004ela.2_Missense_Mutation_p.R62H|MORF4L2_uc004ekx.2_Missense_Mutation_p.R62H|MORF4L2_uc004elb.2_Missense_Mutation_p.R62H|MORF4L2_uc004eky.2_Missense_Mutation_p.R62H|MORF4L2_uc010nos.2_Missense_Mutation_p.R62H|MORF4L2_uc004ekz.2_Missense_Mutation_p.R62H|MORF4L2_uc011mry.1_Missense_Mutation_p.R62H|MORF4L2_uc011mrz.1_Missense_Mutation_p.R62H|MORF4L2_uc004elc.2_Missense_Mutation_p.R62H|MORF4L2_uc004elf.2_Missense_Mutation_p.R62H|MORF4L2_uc004ele.2_Missense_Mutation_p.R62H|MORF4L2_uc011msa.1_Missense_Mutation_p.R62H|MORF4L2_uc011msb.1_Missense_Mutation_p.R62H|MORF4L2_uc011msc.1_Missense_Mutation_p.R62H|MORF4L2_uc011msd.1_Missense_Mutation_p.R62H|MORF4L2_uc004eld.2_Missense_Mutation_p.R62H	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	62					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						CTCTGCAGAGCGACCACCCCA	0.532													T	102931771	T	T	102931771	3	4	204	1	0	0	0	0	1	0	0	0	9707	768	27	1	685	1	MORF4L2	23	102931771	Missense_Mutation	SNP	C	TCGA-28-2509-01A-01D-1494-08	55659481	102931771	52338789	67	14412											
MID2	11043	broad.mit.edu	37	chrX	107084129	107084129	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgctttccagtgtcctacCtgcaggtatgttatctcgct	8	12	1	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:107084129C>T	uc004enl.2	+	2	807	c.234C>T	c.(232-234)ACC>ACT	p.T78T	MID2_uc004enk.2_Silent_p.T78T	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	78	RING-type.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						AGTGTCCTACCTGCAGGTATG	0.512													T	107084129	T	T	107084129	2	4	204	1	0	0	0	0	0	0	0	1	9578	668	24	3		3	MID2	23	107084129	Silent	SNP	C	TCGA-28-2509-01A-01D-1494-08	4152358	107084129	48186431	68	14413											
IRS4	8471	broad.mit.edu	37	chrX	107977802	107977803	+	Frame_Shift_Ins	INS	-	C	C													tcccacttcctgagcctttgINSccccccccagagttcttgcc							TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:107977802_107977803insC	uc004eoc.2	-	1	1805_1806	c.1772_1773insG	c.(1771-1773)GGCfs	p.G591fs		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	591						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTGAGCCTTTGCCCCCCCCAGA	0.545													C	107977803	C	C	107977802	7	5	204	1	0	1	1	0	0	0	0	0	7842	1306	46	0	2004	0	IRS4	23	107977802	Frame_Shift_Ins	INS	-	TCGA-28-2509-01A-01D-1494-08	893673	107977802	47292758	69	14414											
ELF4	2000	broad.mit.edu	37	chrX	129201458	129201458	+	Frame_Shift_Del	DEL	G	-	-													agggccgagcccgaccccacGggggccactcctaggtggat							TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:129201458delG	uc004evd.3	-	9	1615	c.1230delC	c.(1228-1230)CCCfs	p.P410fs	ELF4_uc004eve.3_Frame_Shift_Del_p.P410fs	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	410					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCGACCCCACGGGGGCCACTC	0.592			T	ERG	AML								-	129201458	-	-	129201458	7	5	204	1	0	1	0	1	0	0	0	0	5056	1103	39	0	765	0	ELF4	23	129201458	Frame_Shift_Del	DEL	G	TCGA-28-2509-01A-01D-1494-08	21223656	129201458	26069102	70	14415											
IGSF1	3547	broad.mit.edu	37	chrX	130416634	130416634	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cactccatccactggtcctcGacaccgtaggctcacattct	6	17	2	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:130416634G>A	uc004ewd.2	-	7	1268	c.1030C>T	c.(1030-1032)CGA>TGA	p.R344*	IGSF1_uc004ewe.3_Nonsense_Mutation_p.R333*|IGSF1_uc004ewf.2_Nonsense_Mutation_p.R324*	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	344	Ig-like C2-type 4.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						ACTGGTCCTCGACACCGTAGG	0.488													A	130416634	A	A	130416634	4	1	204	1	0	0	0	0	0	1	0	0	7596	1066	37	2	3051	2	IGSF1	23	130416634	Nonsense_Mutation	SNP	G	TCGA-28-2509-01A-01D-1494-08	1215176	130416634	24853926	71	14416											
DDX26B	203522	broad.mit.edu	37	chrX	134655171	134655171	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccttgccccgcagctgcgCgcccgggacccggccagccg	13	21	0	0			TCGA-28-2509-01A-01D-1494-08	TCGA-28-2509-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4a62fe0-cee2-487a-9a8a-4cd98d8380df	36277954-db5f-4e92-b170-db6c5dd82efa	g.chrX:134655171C>T	uc004eyw.3	+	2	480	c.117C>T	c.(115-117)CGC>CGT	p.R39R		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	39	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CGCAGCTGCGCGCCCGGGACC	0.632													T	134655171	T	T	134655171	2	4	204	1	0	0	0	0	0	0	0	1	4353	755	27	1		1	DDX26B	23	134655171	Silent	SNP	C	TCGA-28-2509-01A-01D-1494-08	4238537	134655171	20615389	72	14417											
FLG	2312	broad.mit.edu	37	chr1	152280065	152280065	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcttcctccagtgctggTcccggtccgtccatgggcgg	13	14	1	0			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr1:152280065T>C	uc001ezu.1	-	3	7333	c.7297A>G	c.(7297-7299)ACC>GCC	p.T2433A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2433	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGTGCTGGTCCCGGTCCGT	0.597									Ichthyosis				C	152280065	C	C	152280065	3	2	205	1	0	0	0	0	1	0	0	0	5922	1667	58	4	4892	4	FLG	1	152280065	Missense_Mutation	SNP	T	TCGA-28-2510-01A-01D-1696-08		152280065	96970556	1	14418											
HMCN1	83872	broad.mit.edu	37	chr1	186057366	186057366	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtgatgccactgggatcCcacctcccacgatagcatgg	10	14	0	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr1:186057366C>T	uc001grq.1	+	62	9764	c.9535C>T	c.(9535-9537)CCA>TCA	p.P3179S		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3179	Ig-like C2-type 30.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CACTGGGATCCCACCTCCCAC	0.433													T	186057366	T	T	186057366	3	4	205	1	0	0	0	0	1	0	0	0	7220	623	22	3	9781	3	HMCN1	1	186057366	Missense_Mutation	SNP	C	TCGA-28-2510-01A-01D-1696-08	33777301	186057366	63193255	2	14419											
LRPPRC	10128	broad.mit.edu	37	chr2	44203309	44203309	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcatgccctgtcacaaggGcactgaatactgcctctgta	10	12	2	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr2:44203309G>A	uc002rtr.2	-	6	768	c.710C>T	c.(709-711)GCC>GTC	p.A237V	LRPPRC_uc010yob.1_Missense_Mutation_p.A137V|LRPPRC_uc010faw.1_Missense_Mutation_p.A211V	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	237	PPR 4.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGTCACAAGGGCACTGAATAC	0.398													A	44203309	A	A	44203309	3	1	205	1	0	0	0	0	1	0	0	0	8965	1203	42	3	3606	3	LRPPRC	2	44203309	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08		44203309	198996064	3	14420											
TTN	7273	broad.mit.edu	37	chr2	179633437	179633437	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctgttgatgttgcttttccAgccacaaaggtgtagtcagc	11	9	1	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr2:179633437A>G	uc010zfg.1	-	38	9350	c.9126T>C	c.(9124-9126)GCT>GCC	p.A3042A	TTN_uc010zfh.1_Silent_p.A2996A|TTN_uc010zfi.1_Silent_p.A2996A|TTN_uc010zfj.1_Silent_p.A2996A|TTN_uc002unb.2_Silent_p.A3042A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3042							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCTTTTCCAGCCACAAAGG	0.388													G	179633437	G	G	179633437	2	3	205	1	0	0	0	0	0	0	0	1	16732	175	7	4		4	TTN	2	179633437	Silent	SNP	A	TCGA-28-2510-01A-01D-1696-08	135430128	179633437	63565936	4	14421											
MUC4	4585	broad.mit.edu	37	chr3	195516052	195516052	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaaggggtagctgtgcccGctgaggtggttcgtgaccct	17	9	0	2	rs142259629	by1000genomes	TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr3:195516052G>A	uc011bto.1	-	2	2859	c.2399C>T	c.(2398-2400)GCG>GTG	p.A800V	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.A682V	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	805	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGCTGTGCCCGCTGAGGTGGT	0.587													A	195516052	A	A	195516052	3	1	205	1	0	0	0	0	1	0	0	0	9978	1087	38	1		1	MUC4	3	195516052	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08		195516052	2506378	5	14422											
LIN54	132660	broad.mit.edu	37	chr4	83905798	83905798	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tagtgtggttactgtacactGtgattggttccgtggaaatg	13	5	0	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr4:83905798G>C	uc003hnx.3	-	2	578	c.200C>G	c.(199-201)ACA>AGA	p.T67R	LIN54_uc003hnz.3_Intron|LIN54_uc003hny.3_Intron|LIN54_uc010ijt.2_Missense_Mutation_p.T67R|LIN54_uc010iju.2_5'UTR|LIN54_uc010ijv.2_Intron	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	67					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				ACTGTACACTGTGATTGGTTC	0.428													C	83905798	C	C	83905798	3	2	205	1	0	0	0	0	1	0	0	0	8809	1377	48	5	2097	5	LIN54	4	83905798	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08		83905798	107248478	6	14423											
CLCN3	1182	broad.mit.edu	37	chr4	170610366	170610366	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aaaacatgggcagaattaatCataggtcaagcagaggtaag	11	5	2	2			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr4:170610366C>G	uc003isi.2	+	5	1100	c.591C>G	c.(589-591)ATC>ATG	p.I197M	CLCN3_uc003ish.2_Missense_Mutation_p.I197M|CLCN3_uc011cjz.1_Missense_Mutation_p.I180M|CLCN3_uc011cka.1_Missense_Mutation_p.I197M|CLCN3_uc003isj.1_Missense_Mutation_p.I170M	NM_001829	NP_001820	P51790	CLCN3_HUMAN	chloride channel 3 isoform b	197					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(2)|ovary(1)	3		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		CAGAATTAATCATAGGTCAAG	0.353													G	170610366	G	G	170610366	3	3	205	1	0	0	0	0	1	0	0	0	3464	816	29	5	605	5	CLCN3	4	170610366	Missense_Mutation	SNP	C	TCGA-28-2510-01A-01D-1696-08	86704568	170610366	20543910	7	14424											
LRRC16A	55604	broad.mit.edu	37	chr6	25606465	25606465	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtctggcagcacggcccGtcatcccgcagaaaccaaga	10	16	2	2			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr6:25606465G>A	uc011djw.1	+	35	4187	c.3811G>A	c.(3811-3813)GTC>ATC	p.V1271I	LRRC16A_uc010jpx.2_Missense_Mutation_p.V1226I|LRRC16A_uc010jpy.2_Missense_Mutation_p.V1265I	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1271					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						AGCACGGCCCGTCATCCCGCA	0.607													A	25606465	A	A	25606465	3	1	205	1	0	0	0	0	1	0	0	0	8971	1145	40	1	3949	1	LRRC16A	6	25606465	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08		25606465	145508602	8	14425											
CHN2	1124	broad.mit.edu	37	chr7	29407575	29407575	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttacagcaagaggcacctcGtcccaagagaatcatttgtc	9	11	1	2			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr7:29407575G>A	uc003szz.2	+	3	553	c.116G>A	c.(115-117)CGT>CAT	p.R39H	CHN2_uc011jzs.1_Missense_Mutation_p.R114H|CHN2_uc010kva.2_Intron|CHN2_uc010kvb.2_RNA|CHN2_uc010kvc.2_Intron|CHN2_uc011jzt.1_Missense_Mutation_p.R52H|CHN2_uc010kvd.2_Missense_Mutation_p.R39H|CHN2_uc011jzu.1_Missense_Mutation_p.R24H	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	39					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						GAGGCACCTCGTCCCAAGAGA	0.413													A	29407575	A	A	29407575	3	1	205	1	0	0	0	0	1	0	0	0	3363	1145	40	1	126	1	CHN2	7	29407575	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08		29407575	129731088	9	14426											
SAMD9	54809	broad.mit.edu	37	chr7	92731863	92731863	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cataccgcctttttgacttcGgatacaatctttccttcact	4	13	2	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr7:92731863G>A	uc003umf.2	-	3	3804	c.3548C>T	c.(3547-3549)CCG>CTG	p.P1183L	SAMD9_uc003umg.2_Missense_Mutation_p.P1183L	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1183						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTTGACTTCGGATACAATCT	0.378													A	92731863	A	A	92731863	3	1	205	1	0	0	0	0	1	0	0	0	13826	1116	39	2	1225	2	SAMD9	7	92731863	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08	63324288	92731863	66406800	10	14427											
PTEN	5728	broad.mit.edu	37	chr10	89711900	89711900	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactattcccagtcagaggcGctatgtgtattattatagct	8	8	1	1	rs121913294		TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr10:89711900G>A	uc001kfb.2	+	7	1549	c.518G>A	c.(517-519)CGC>CAC	p.R173H		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	173	Phosphatase tensin-type.		R -> C (in endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3; retains ability to bind phospholipid membranes).|R -> P (loss of phosphatase activity towards Ins(1,3,4,5)P4).|R -> H (loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R173C(32)|p.R173H(22)|p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.R173fs*10(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G165_K342del(1)|p.G165_*404del(1)|p.R173R(1)|p.R173P(1)|p.R172fs*5(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGTCAGAGGCGCTATGTGTAT	0.348	R173H(RL952_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89711900	A	A	89711900	3	1	205	1	0	0	0	0	1	0	0	0	12738	1087	38	1	540	1	PTEN	10	89711900	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08		89711900	45822847	11	14428											
POLL	27343	broad.mit.edu	37	chr10	103342623	103342623	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtcagggaggcctggctgCggatgtcttccagacttcgg	15	10	2	1	rs146112511		TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr10:103342623C>T	uc001ktg.1	-	6	1857	c.1091G>A	c.(1090-1092)CGC>CAC	p.R364H	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_Missense_Mutation_p.R37H|POLL_uc001kte.1_Missense_Mutation_p.R56H|POLL_uc001kth.1_Missense_Mutation_p.R89H|POLL_uc001kti.1_Missense_Mutation_p.R364H|POLL_uc001ktj.1_Missense_Mutation_p.R364H|POLL_uc001ktf.2_Missense_Mutation_p.R272H|POLL_uc001ktk.1_Missense_Mutation_p.R103H|POLL_uc010qqa.1_Missense_Mutation_p.R103H|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Missense_Mutation_p.R364H|POLL_uc001ktl.2_Missense_Mutation_p.R276H|POLL_uc010qqc.1_Missense_Mutation_p.R56H	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	364					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GGCCTGGCTGCGGATGTCTTC	0.552								DNA_polymerases_(catalytic_subunits)					T	103342623	T	T	103342623	3	4	205	1	0	0	0	0	1	0	0	0	12205	768	27	1	648	1	POLL	10	103342623	Missense_Mutation	SNP	C	TCGA-28-2510-01A-01D-1696-08	13630723	103342623	32192124	12	14429											
C10orf96	374355	broad.mit.edu	37	chr10	118084588	118084588	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaggcggaggagagtcgccGtttgatgcgagaaggtcggg	19	7	1	3			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr10:118084588G>A	uc001lck.2	+	2	316	c.65G>A	c.(64-66)CGT>CAT	p.R22H		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	22	Potential.									ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		GAGAGTCGCCGTTTGATGCGA	0.557													A	118084588	A	A	118084588	3	1	205	1	0	0	0	0	1	0	0	0	1627	1145	40	1	67	1	C10orf96	10	118084588	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08	14741965	118084588	17450159	13	14430											
LPXN	9404	broad.mit.edu	37	chr11	58318640	58318640	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacccccaagcattgagtcCagggaggccttgtgatcctg	12	12	0	3			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr11:58318640C>T	uc001nmw.2	-	5	529	c.384G>A	c.(382-384)CTG>CTA	p.L128L	LPXN_uc009ymp.2_5'UTR|LPXN_uc010rkj.1_Silent_p.L133L|LPXN_uc010rkk.1_Silent_p.L108L|LPXN_uc010rkl.1_RNA	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	128					cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GCATTGAGTCCAGGGAGGCCT	0.557													T	58318640	T	T	58318640	2	4	205	1	0	0	0	0	0	0	0	1	8929	581	21	3		3	LPXN	11	58318640	Silent	SNP	C	TCGA-28-2510-01A-01D-1696-08		58318640	76687876	14	14431											
AHNAK	79026	broad.mit.edu	37	chr11	62296010	62296010	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actccagctcaacatcaggcAcctccacacccacactggga	6	18	2	0			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr11:62296010A>G	uc001ntl.2	-	5	6179	c.5879T>C	c.(5878-5880)GTG>GCG	p.V1960A	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1960					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AACATCAGGCACCTCCACACC	0.507													G	62296010	G	G	62296010	3	3	205	1	0	0	0	0	1	0	0	0	414	159	6	4	11913	4	AHNAK	11	62296010	Missense_Mutation	SNP	A	TCGA-28-2510-01A-01D-1696-08	3977370	62296010	72710506	15	14432											
C11orf65	160140	broad.mit.edu	37	chr11	108302505	108302505	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatatatttcactatctgacGtggttctccttgtcttctta	5	9	5	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr11:108302505G>A	uc001pkh.2	-	3	212	c.142C>T	c.(142-144)CGT>TGT	p.R48C	C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_RNA	NM_152587	NP_689800	Q8NCR3	CK065_HUMAN	hypothetical protein LOC160140	48										ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		ACTATCTGACGTGGTTCTCCT	0.299													A	108302505	A	A	108302505	3	1	205	1	0	0	0	0	1	0	0	0	1655	1145	40	1	827	1	C11orf65	11	108302505	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08	46006495	108302505	26704011	16	14433											
OR8D1	283159	broad.mit.edu	37	chr11	124180280	124180280	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgcattataaagcagtgggCtacagatggcaacatagcga	11	8	0	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr11:124180280C>T	uc010sag.1	-	1	383	c.383G>A	c.(382-384)AGC>AAC	p.S128N		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AAGCAGTGGGCTACAGATGGC	0.498													T	124180280	T	T	124180280	3	4	205	1	0	0	0	0	1	0	0	0	11231	797	28	3	546	3	OR8D1	11	124180280	Missense_Mutation	SNP	C	TCGA-28-2510-01A-01D-1696-08	15877775	124180280	10826236	17	14434											
ZBTB39	9880	broad.mit.edu	37	chr12	57396726	57396726	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agactgtgcagcggtacatgAgggcccccgagtgtgtcttt	14	10	1	2			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr12:57396726A>G	uc001sml.1	-	2	2062	c.1976T>C	c.(1975-1977)CTC>CCC	p.L659P	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	659					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						GCGGTACATGAGGGCCCCCGA	0.557													G	57396726	G	G	57396726	3	3	205	1	0	0	0	0	1	0	0	0	17537	304	11	4	166	4	ZBTB39	12	57396726	Missense_Mutation	SNP	A	TCGA-28-2510-01A-01D-1696-08		57396726	76455169	18	14435											
CUX2	23316	broad.mit.edu	37	chr12	111748209	111748209	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgcggatggtggtgggggCggagcggcggggcccggggc	25	11	0	0			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr12:111748209C>T	uc001tsa.1	+	15	1776	c.1623C>T	c.(1621-1623)GGC>GGT	p.G541G		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	541						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GTGGTGGGGGCGGAGCGGCGG	0.721													T	111748209	T	T	111748209	2	4	205	1	0	0	0	0	0	0	0	1	4065	755	27	1		1	CUX2	12	111748209	Silent	SNP	C	TCGA-28-2510-01A-01D-1696-08	54351483	111748209	22103686	19	14436											
RIMBP2	23504	broad.mit.edu	37	chr12	130898833	130898833	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catagaagtctggagaaaggCggtctcgcccgtaatcgtct	12	10	3	2			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr12:130898833C>T	uc001uil.2	-	14	2653	c.2489G>A	c.(2488-2490)CGC>CAC	p.R830H		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	830						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGGAGAAAGGCGGTCTCGCCC	0.572													T	130898833	T	T	130898833	3	4	205	1	0	0	0	0	1	0	0	0	13363	768	27	1	693	1	RIMBP2	12	130898833	Missense_Mutation	SNP	C	TCGA-28-2510-01A-01D-1696-08	19150624	130898833	2953062	20	14437											
NID2	22795	broad.mit.edu	37	chr14	52507433	52507433	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgtgaaatttgctgagacGtaaggcacctggccttgaat	12	8	0	3			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr14:52507433G>A	uc001wzo.2	-	8	2196	c.1962C>T	c.(1960-1962)TAC>TAT	p.Y654Y	NID2_uc010tqs.1_Silent_p.Y654Y|NID2_uc010tqt.1_Silent_p.Y654Y|NID2_uc001wzp.2_Silent_p.Y654Y	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	654	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TTGCTGAGACGTAAGGCACCT	0.443													A	52507433	A	A	52507433	2	1	205	1	0	0	0	0	0	0	0	1	10415	1140	40	1		1	NID2	14	52507433	Silent	SNP	G	TCGA-28-2510-01A-01D-1696-08		52507433	54842107	21	14438											
RBM25	58517	broad.mit.edu	37	chr14	73578303	73578303	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctacctgtagatagtgtcttTaacaaatttgaggatgaaga	9	5	1	4			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr14:73578303T>C	uc001xno.2	+	16	2293	c.2085T>C	c.(2083-2085)TTT>TTC	p.F695F	RBM25_uc010ttu.1_Silent_p.F695F|RBM25_uc001xnp.2_Silent_p.F490F	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	695					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		ATAGTGTCTTTAACAAATTTG	0.403													C	73578303	C	C	73578303	2	2	205	1	0	0	0	0	0	0	0	1	13125	1751	61	4		4	RBM25	14	73578303	Silent	SNP	T	TCGA-28-2510-01A-01D-1696-08	21070870	73578303	33771237	22	14439											
ADAM10	102	broad.mit.edu	37	chr15	58904096	58904096	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagagctgtgaagccattacAtattccttcccttgcacagt	8	11	0	2			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr15:58904096A>C	uc002afd.1	-	12	2050	c.1606T>G	c.(1606-1608)TGT>GGT	p.C536G	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Missense_Mutation_p.C235G|ADAM10_uc002afe.1_Intron|ADAM10_uc002aff.1_Missense_Mutation_p.C73G	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	536	Extracellular (Potential).|Disintegrin.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		AAGCCATTACATATTCCTTCC	0.448													C	58904096	C	C	58904096	3	2	205	1	0	0	0	0	1	0	0	0	234	217	8	5	660	5	ADAM10	15	58904096	Missense_Mutation	SNP	A	TCGA-28-2510-01A-01D-1696-08		58904096	43627296	23	14440											
SNX29	92017	broad.mit.edu	37	chr16	12220512	12220512	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaactgcgccaggccactgtGgccatgatgaacaggaagga	14	10	0	2			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr16:12220512G>A	uc002dby.3	+	5	326	c.270G>A	c.(268-270)GTG>GTA	p.V90V	SNX29_uc010uyx.1_Silent_p.V117V	NM_001080530	NP_001073999	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	90	Potential.				cell communication		phosphatidylinositol binding			ovary(1)	1						AGGCCACTGTGGCCATGATGA	0.488													A	12220512	A	A	12220512	2	1	205	1	0	0	0	0	0	0	0	1	14898	1335	47	3		3	SNX29	16	12220512	Silent	SNP	G	TCGA-28-2510-01A-01D-1696-08		12220512	78134241	24	14441											
GTF3C1	2975	broad.mit.edu	37	chr16	27480738	27480738	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgccgggggagtagtagcCcctcatcagcaggtagttgg	16	9	2	0			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr16:27480738C>T	uc002dov.1	-	32	4988	c.4948G>A	c.(4948-4950)GGC>AGC	p.G1650S	GTF3C1_uc002dou.2_Missense_Mutation_p.G1650S	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1650						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GAGTAGTAGCCCCTCATCAGC	0.602													T	27480738	T	T	27480738	3	4	205	1	0	0	0	0	1	0	0	0	6872	623	22	3	1405	3	GTF3C1	16	27480738	Missense_Mutation	SNP	C	TCGA-28-2510-01A-01D-1696-08	15260226	27480738	62874015	25	14442											
CTAGE1	64693	broad.mit.edu	37	chr18	19997766	19997766	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaccataaggatgagaatcGggtctcataccttcagtcag	9	9	3	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr18:19997766G>A	uc002ktv.1	-	1	113	c.9C>T	c.(7-9)CCC>CCT	p.P3P		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	3						integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GATGAGAATCGGGTCTCATAC	0.507													A	19997766	A	A	19997766	2	1	205	1	0	0	0	0	0	0	0	1	3992	1103	39	2		2	CTAGE1	18	19997766	Silent	SNP	G	TCGA-28-2510-01A-01D-1696-08		19997766	58079482	26	14443											
SERPINB4	6318	broad.mit.edu	37	chr18	61325755	61325755	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggctctcctaccattcgttTgactttccacccaggagtta	7	13	1	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr18:61325755T>A	uc002ljg.2	-	4	487	c.461A>T	c.(460-462)CAA>CTA	p.Q154L	SERPINB3_uc002lji.2_Missense_Mutation_p.Q154L|SERPINB3_uc010dqa.2_Missense_Mutation_p.Q154L|SERPINB3_uc010dqb.2_3'UTR			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	154					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						ACCATTCGTTTGACTTTCCAC	0.448													A	61325755	A	A	61325755	3	1	205	1	0	0	0	0	1	0	0	0	14103	1812	63	5		5	SERPINB4	18	61325755	Missense_Mutation	SNP	T	TCGA-28-2510-01A-01D-1696-08	41327989	61325755	16751493	27	14444											
OR7A5	26659	broad.mit.edu	37	chr19	14938368	14938368	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgtacttcccctgagctgatGagattgcatgtatggaagaa	11	7	0	4			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr19:14938368G>A	uc002mzw.2	-	1	909	c.686C>T	c.(685-687)TCA>TTA	p.S229L	OR7A5_uc010xoa.1_Missense_Mutation_p.S229L	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						CTGAGCTGATGAGATTGCATG	0.448													A	14938368	A	A	14938368	3	1	205	1	0	0	0	0	1	0	0	0	11216	1294	45	3	277	3	OR7A5	19	14938368	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08		14938368	44190615	28	14445											
HIPK4	147746	broad.mit.edu	37	chr19	40890043	40890043	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gctggcggatccgaagtcaaTcacctgtcgggggtggggaa	17	9	2	0			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr19:40890043T>C	uc002onp.2	-	2	754	c.469A>G	c.(469-471)ATT>GTT	p.I157V		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	157	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CCGAAGTCAATCACCTGTCGG	0.627													C	40890043	C	C	40890043	3	2	205	1	0	0	0	0	1	0	0	0	7119	1435	50	4	1393	4	HIPK4	19	40890043	Missense_Mutation	SNP	T	TCGA-28-2510-01A-01D-1696-08	25951675	40890043	18238940	29	14446											
SPTBN4	57731	broad.mit.edu	37	chr19	41060491	41060491	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaggcgtggagaactacgagGaaagcatcgcgcagctgtcg	15	9	0	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr19:41060491G>A	uc002ony.2	+	24	5109	c.5023G>A	c.(5023-5025)GAA>AAA	p.E1675K	SPTBN4_uc002onx.2_Missense_Mutation_p.E1675K|SPTBN4_uc002onz.2_Missense_Mutation_p.E1675K|SPTBN4_uc010egx.2_Missense_Mutation_p.E418K|SPTBN4_uc010egy.1_Missense_Mutation_p.E351K|SPTBN4_uc002ooa.2_Missense_Mutation_p.E351K	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1675	Spectrin 14.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAACTACGAGGAAAGCATCGC	0.662													A	41060491	A	A	41060491	3	1	205	1	0	0	0	0	1	0	0	0	15120	1175	41	3	5113	3	SPTBN4	19	41060491	Missense_Mutation	SNP	G	TCGA-28-2510-01A-01D-1696-08	170448	41060491	18068492	30	14447											
KLK13	26085	broad.mit.edu	37	chr19	51563780	51563780	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttgcactagtagggcagccTgccagggctgagagtggggg	18	9	0	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr19:51563780T>C	uc002pvn.2	-	2	192	c.149A>G	c.(148-150)CAG>CGG	p.Q50R	KLK13_uc002pvl.2_RNA|KLK13_uc002pvm.2_RNA|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Missense_Mutation_p.Q50R|KLK13_uc002pvq.2_RNA|KLK13_uc010eoo.2_Intron|KLK13_uc002pvr.2_Missense_Mutation_p.Q50R	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor	50	Peptidase S1.				proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		TAGGGCAGCCTGCCAGGGCTG	0.602													C	51563780	C	C	51563780	3	2	205	1	0	0	0	0	1	0	0	0	8401	1580	55	4	700	4	KLK13	19	51563780	Missense_Mutation	SNP	T	TCGA-28-2510-01A-01D-1696-08	10503289	51563780	7565203	31	14448											
NLRP4	147945	broad.mit.edu	37	chr19	56372800	56372800	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cacatctgctctgtgctcacCaccagcgggcacctcagaga	9	16	4	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chr19:56372800C>A	uc002qmd.3	+	4	2327	c.1905C>A	c.(1903-1905)ACC>ACA	p.T635T	NLRP4_uc002qmf.2_Silent_p.T560T|NLRP4_uc010etf.2_Silent_p.T466T	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	635							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CTGTGCTCACCACCAGCGGGC	0.592													A	56372800	A	A	56372800	2	1	205	1	0	0	0	0	0	0	0	1	10479	581	21	5		5	NLRP4	19	56372800	Silent	SNP	C	TCGA-28-2510-01A-01D-1696-08	4809020	56372800	2756183	32	14449											
BEND2	139105	broad.mit.edu	37	chrX	18195711	18195711	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcaatgcagccattttgttCgggtcgagggattggctgtc	13	9	1	0	rs150572716		TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chrX:18195711C>T	uc004cyj.3	-	10	1762	c.1608G>A	c.(1606-1608)CCG>CCA	p.P536P	BEND2_uc010nfb.2_Silent_p.P445P	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	536	BEN 1.							p.P536P(1)		ovary(3)|kidney(1)|central_nervous_system(1)	5						CCATTTTGTTCGGGTCGAGGG	0.388													T	18195711	T	T	18195711	2	4	205	1	0	0	0	0	0	0	0	1	1398	871	31	2		2	BEND2	23	18195711	Silent	SNP	C	TCGA-28-2510-01A-01D-1696-08		18195711	137074849	33	14450											
YY2	404281	broad.mit.edu	37	chrX	21875351	21875351	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaaaggtccaaaggagaacCtcccaaaacagtcccttgct	7	13	0	1			TCGA-28-2510-01A-01D-1696-08	TCGA-28-2510-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f2dc303-9859-4b63-8aab-c387da4b2cc1	1ac0c79f-5de9-404e-88fd-a3533e56ea51	g.chrX:21875351C>T	uc011mjp.1	+	1	749	c.749C>T	c.(748-750)CCT>CTT	p.P250L	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Missense_Mutation_p.P468L|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	250	Mediates transcriptional repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AAAGGAGAACCTCCCAAAACA	0.502													T	21875351	T	T	21875351	3	4	205	1	0	0	0	0	1	0	0	0	17506	681	24	3	751	3	YY2	23	21875351	Missense_Mutation	SNP	C	TCGA-28-2510-01A-01D-1696-08	3679640	21875351	133395209	34	14451											
ZFYVE9	9372	broad.mit.edu	37	chr1	52704095	52704095	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgaagaatccctccggtctGgtttacctttgcttctcaaa	7	12	2	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr1:52704095G>T	uc001cto.2	+	4	1178	c.1006G>T	c.(1006-1008)GGT>TGT	p.G336C	ZFYVE9_uc001ctn.2_Missense_Mutation_p.G336C|ZFYVE9_uc001ctp.2_Missense_Mutation_p.G336C	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	336					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						CCTCCGGTCTGGTTTACCTTT	0.468													T	52704095	T	T	52704095	3	4	206	1	0	0	0	0	1	0	0	0	17668	1348	47	5	1012	5	ZFYVE9	1	52704095	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08		52704095	196546526	1	14452											
FLG	2312	broad.mit.edu	37	chr1	152275656	152275656	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatcgcggtgagaggatccGgggtgtctggagccatctct	16	9	2	1	rs147335121		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr1:152275656G>A	uc001ezu.1	-	3	11742	c.11706C>T	c.(11704-11706)CCC>CCT	p.P3902P		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3902	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGAGGATCCGGGGTGTCTGG	0.517									Ichthyosis				A	152275656	A	A	152275656	2	1	206	1	0	0	0	0	0	0	0	1	5922	1103	39	2		2	FLG	1	152275656	Silent	SNP	G	TCGA-28-2513-01A-01D-1494-08	99571561	152275656	96974965	2	14453											
FLG2	388698	broad.mit.edu	37	chr1	152329436	152329436	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ataaccacatgcatgacttcGcctcccactgtctcctgaac	5	16	1	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr1:152329436G>A	uc001ezw.3	-	3	899	c.826C>T	c.(826-828)CGA>TGA	p.R276*	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	276	Ser-rich.|Filaggrin 1.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCATGACTTCGCCTCCCACTG	0.448													A	152329436	A	A	152329436	4	1	206	1	0	0	0	0	0	1	0	0	5923	1095	38	1	6353	1	FLG2	1	152329436	Nonsense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	53780	152329436	96921185	3	14454											
PFDN2	5202	broad.mit.edu	37	chr1	161072146	161072146	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcgctgttcctgccgaaggCggttgaagccagcaatcacc	11	14	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr1:161072146C>T	uc001fxu.2	-	2	145	c.95G>A	c.(94-96)CGC>CAC	p.R32H		NM_012394	NP_036526	Q9UHV9	PFD2_HUMAN	prefoldin subunit 2	32				GFNRLR -> SFNAF (in Ref. 3; AAF36151).	'de novo' posttranslational protein folding	prefoldin complex	unfolded protein binding				0	all_cancers(52;1.84e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTGCCGAAGGCGGTTGAAGCC	0.527													T	161072146	T	T	161072146	3	4	206	1	0	0	0	0	1	0	0	0	11756	768	27	1	381	1	PFDN2	1	161072146	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	8742710	161072146	88178475	4	14455											
HMCN1	83872	broad.mit.edu	37	chr1	186114957	186114957	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaggaggtgaaaagactcGgaagcggctgtgcgaccatc	16	8	0	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr1:186114957G>A	uc001grq.1	+	93	14739	c.14510G>A	c.(14509-14511)CGG>CAG	p.R4837Q	HMCN1_uc001grs.1_Missense_Mutation_p.R406Q	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4837	TSP type-1 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAAAAGACTCGGAAGCGGCTG	0.552													A	186114957	A	A	186114957	3	1	206	1	0	0	0	0	1	0	0	0	7220	1116	39	2	14880	2	HMCN1	1	186114957	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	25042811	186114957	63135664	5	14456											
CACNA1S	779	broad.mit.edu	37	chr1	201047161	201047161	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatagacatgaagtactggcGcaggcccagcccgtacatct	11	12	1	2	rs138364213		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr1:201047161G>A	uc001gvv.2	-	11	1692	c.1465C>T	c.(1465-1467)CGC>TGC	p.R489C		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	489	II.|Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAGTACTGGCGCAGGCCCAGC	0.582													A	201047161	A	A	201047161	3	1	206	1	0	0	0	0	1	0	0	0	2547	1087	38	1	4292	1	CACNA1S	1	201047161	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	14932204	201047161	48203460	6	14457											
NRXN1	9378	broad.mit.edu	37	chr2	50765581	50765581	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccggatatctttgctttgGccatcgatgaacaaatccct	8	11	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr2:50765581G>A	uc010fbq.2	-	10	3550	c.2073C>T	c.(2071-2073)GGC>GGT	p.G691G	NRXN1_uc002rxb.3_Silent_p.G323G|NRXN1_uc002rxe.3_Silent_p.G651G|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTTTGCTTTGGCCATCGATGA	0.502													A	50765581	A	A	50765581	2	1	206	1	0	0	0	0	0	0	0	1	10665	1190	42	3		3	NRXN1	2	50765581	Silent	SNP	G	TCGA-28-2513-01A-01D-1494-08		50765581	192433792	7	14458											
PSD4	23550	broad.mit.edu	37	chr2	113940279	113940279	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggagctgggtccatcaggaCgggctggagccttgccagga	18	10	1	0	rs147089589		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr2:113940279C>T	uc002tjc.2	+	2	429	c.246C>T	c.(244-246)GAC>GAT	p.D82D	PSD4_uc002tjd.2_Translation_Start_Site|PSD4_uc002tje.2_Silent_p.D81D|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	82					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TCCATCAGGACGGGCTGGAGC	0.622													T	113940279	T	T	113940279	2	4	206	1	0	0	0	0	0	0	0	1	12649	535	19	1		1	PSD4	2	113940279	Silent	SNP	C	TCGA-28-2513-01A-01D-1494-08	63174698	113940279	129259094	8	14459											
SLC4A10	57282	broad.mit.edu	37	chr2	162815003	162815003	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgttcttttacagtttattCccatgccagtgctatatgga	7	8	1	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr2:162815003C>T	uc002ubx.3	+	21	2984	c.2800C>T	c.(2800-2802)CCC>TCC	p.P934S	SLC4A10_uc002uby.3_Missense_Mutation_p.P904S|SLC4A10_uc010zcs.1_Missense_Mutation_p.P915S	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	934	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						ACAGTTTATTCCCATGCCAGT	0.343													T	162815003	T	T	162815003	3	4	206	1	0	0	0	0	1	0	0	0	14651	855	30	3	2967	3	SLC4A10	2	162815003	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	48874724	162815003	80384370	9	14460											
TTN	7273	broad.mit.edu	37	chr2	179469893	179469893	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgggtttttcaattacagttTcatttttggaccattcaatc	6	7	3	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr2:179469893T>G	uc010zfg.1	-	229	46531	c.46307A>C	c.(46306-46308)GAA>GCA	p.E15436A	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E9131A|TTN_uc010zfi.1_Missense_Mutation_p.E9064A|TTN_uc010zfj.1_Missense_Mutation_p.E8939A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16363							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTACAGTTTCATTTTTGGA	0.468													G	179469893	G	G	179469893	3	3	206	1	0	0	0	0	1	0	0	0	16732	1783	62	5	54014	5	TTN	2	179469893	Missense_Mutation	SNP	T	TCGA-28-2513-01A-01D-1494-08	16654890	179469893	63729480	10	14461											
ZNF804A	91752	broad.mit.edu	37	chr2	185802437	185802437	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaaagattctatcgaaaaCgtagacaacattcacattct	5	9	3	3			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr2:185802437C>T	uc002uph.2	+	4	2908	c.2314C>T	c.(2314-2316)CGT>TGT	p.R772C		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	772						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CTATCGAAAACGTAGACAACA	0.343													T	185802437	T	T	185802437	3	4	206	1	0	0	0	0	1	0	0	0	18167	536	19	1	2328	1	ZNF804A	2	185802437	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	6332544	185802437	57396936	11	14462											
NBEAL1	65065	broad.mit.edu	37	chr2	204000539	204000539	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcataagcacagtagagctgTtttaatgaaagacaatgata	8	5	1	4			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr2:204000539T>C	uc002uzt.3	+	27	4199	c.3866T>C	c.(3865-3867)GTT>GCT	p.V1289A	NBEAL1_uc002uzs.3_5'UTR	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1289							binding			ovary(1)|skin(1)	2						AGTAGAGCTGTTTTAATGAAA	0.343													C	204000539	C	C	204000539	3	2	206	1	0	0	0	0	1	0	0	0	10188	1725	60	4	3968	4	NBEAL1	2	204000539	Missense_Mutation	SNP	T	TCGA-28-2513-01A-01D-1494-08	18198102	204000539	39198834	12	14463											
CADM2	253559	broad.mit.edu	37	chr3	85932587	85932587	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttccaaggcatatctcaccGttctgggtaagtgcaaggga	11	10	2	0	rs138383256		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr3:85932587G>A	uc003dqj.2	+	3	984	c.358G>A	c.(358-360)GTT>ATT	p.V120I	CADM2_uc003dqk.2_Missense_Mutation_p.V129I|CADM2_uc003dql.2_Missense_Mutation_p.V122I	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	120	Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		ATATCTCACCGTTCTGGGTAA	0.358													A	85932587	A	A	85932587	3	1	206	1	0	0	0	0	1	0	0	0	2567	1145	40	1	439	1	CADM2	3	85932587	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08		85932587	112089843	13	14464											
MYLK	4638	broad.mit.edu	37	chr3	123333123	123333123	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagttcccgtcctcatcgtaGtctatctggaagtggcggga	12	11	3	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr3:123333123G>A	uc003ego.2	-	34	5856	c.5574C>T	c.(5572-5574)GAC>GAT	p.D1858D	uc003egk.2_Intron|MYLK_uc003egl.2_Silent_p.D98D|MYLK_uc003egm.2_Silent_p.D97D|MYLK_uc010hrr.2_Silent_p.D293D|MYLK_uc011bjv.1_Silent_p.D658D|MYLK_uc011bjw.1_Silent_p.D1857D|MYLK_uc003egp.2_Silent_p.D1789D|MYLK_uc003egq.2_Silent_p.D1807D|MYLK_uc003egr.2_Silent_p.D1738D|MYLK_uc003egs.2_Silent_p.D1682D	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1858	Ig-like C2-type 9.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCTCATCGTAGTCTATCTGGA	0.502													A	123333123	A	A	123333123	2	1	206	1	0	0	0	0	0	0	0	1	10056	1020	36	3		3	MYLK	3	123333123	Silent	SNP	G	TCGA-28-2513-01A-01D-1494-08	37400536	123333123	74689307	14	14465											
ZBBX	79740	broad.mit.edu	37	chr3	167035369	167035369	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atctggtagcattttaaaaaGttgctcttgtggagttctac	9	6	3	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr3:167035369G>C	uc003fep.2	-	13	1323	c.1000C>G	c.(1000-1002)CTT>GTT	p.L334V	ZBBX_uc011bpc.1_Missense_Mutation_p.L334V|ZBBX_uc003feq.2_Missense_Mutation_p.L305V	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	334						intracellular	zinc ion binding			ovary(2)	2						ATTTTAAAAAGTTGCTCTTGT	0.348													C	167035369	C	C	167035369	3	2	206	1	0	0	0	0	1	0	0	0	17513	1029	36	5	1438	5	ZBBX	3	167035369	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	43702246	167035369	30987061	15	14466											
ABCC5	10057	broad.mit.edu	37	chr3	183665139	183665139	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcataagagatggcgagaccCgcataggctgggggaatctg	16	8	1	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr3:183665139C>A	uc003fmg.2	-	23	3552	c.3387G>T	c.(3385-3387)GCG>GCT	p.A1129A	ABCC5_uc011bqt.1_Silent_p.A657A|ABCC5_uc010hxl.2_Silent_p.A1086A	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1129	ABC transmembrane type-1 2.|Helical; (Potential).					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGGCGAGACCCGCATAGGCTG	0.567													A	183665139	A	A	183665139	2	1	206	1	0	0	0	0	0	0	0	1	56	639	23	5		5	ABCC5	3	183665139	Silent	SNP	C	TCGA-28-2513-01A-01D-1494-08	16629770	183665139	14357291	16	14467											
EIF4G1	1981	broad.mit.edu	37	chr3	184044341	184044341	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccatcgattctaacaaccaGctctttgcacctggagggcg	9	13	2	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr3:184044341G>A	uc003fnp.2	+	22	3447	c.3249G>A	c.(3247-3249)CAG>CAA	p.Q1083Q	EIF4G1_uc003fnt.2_Silent_p.Q794Q|EIF4G1_uc003fnq.2_Silent_p.Q996Q|EIF4G1_uc003fnr.2_Silent_p.Q919Q|EIF4G1_uc010hxx.2_Silent_p.Q1090Q|EIF4G1_uc003fns.2_Silent_p.Q1043Q|EIF4G1_uc010hxy.2_Silent_p.Q1090Q|EIF4G1_uc003fnv.3_Silent_p.Q1084Q|EIF4G1_uc003fnu.3_Silent_p.Q1083Q|EIF4G1_uc003fnw.2_Silent_p.Q1090Q|EIF4G1_uc003fnx.2_Silent_p.Q888Q|EIF4G1_uc003fny.3_Silent_p.Q887Q|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1083	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTAACAACCAGCTCTTTGCAC	0.587													A	184044341	A	A	184044341	2	1	206	1	0	0	0	0	0	0	0	1	5036	962	34	3		3	EIF4G1	3	184044341	Silent	SNP	G	TCGA-28-2513-01A-01D-1494-08	379202	184044341	13978089	17	14468											
CCDC96	257236	broad.mit.edu	37	chr4	7043696	7043696	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gaagcgtcgccactccttctCcaccctggtgagcttctcct	8	17	2	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr4:7043696C>A	uc003gjv.2	-	1	1033	c.970G>T	c.(970-972)GAG>TAG	p.E324*	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	324	Potential.										0						CACTCCTTCTCCACCCTGGTG	0.642													A	7043696	A	A	7043696	4	1	206	1	0	0	0	0	0	1	0	0	2874	864	30	5	701	5	CCDC96	4	7043696	Nonsense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08		7043696	184110580	18	14469											
FGFBP1	9982	broad.mit.edu	37	chr4	15937922	15937922	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgggcaacttgtttccaatAgactctctcatccttgagct	7	13	2	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr4:15937922A>G	uc003gom.2	-	2	452	c.334T>C	c.(334-336)TAT>CAT	p.Y112H		NM_005130	NP_005121	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	112					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding				0						TGTTTCCAATAGACTCTCTCA	0.448													G	15937922	G	G	15937922	3	3	206	1	0	0	0	0	1	0	0	0	5860	420	15	4	374	4	FGFBP1	4	15937922	Missense_Mutation	SNP	A	TCGA-28-2513-01A-01D-1494-08	8894226	15937922	175216354	19	14470											
ARAP2	116984	broad.mit.edu	37	chr4	36168644	36168644	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctacattcataggaattatgGtaataccaagtccactctta	5	9	2	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr4:36168644G>C	uc003gsq.1	-	10	2221	c.1883C>G	c.(1882-1884)ACC>AGC	p.T628S	ARAP2_uc003gsr.1_Missense_Mutation_p.T628S	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	628	PH 2.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AGGAATTATGGTAATACCAAG	0.294													C	36168644	C	C	36168644	3	2	206	1	0	0	0	0	1	0	0	0	839	1261	44	5	3327	5	ARAP2	4	36168644	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	20230722	36168644	154985632	20	14471											
RBM47	54502	broad.mit.edu	37	chr4	40440352	40440352	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttcttcatcttgtcggccgCgctggcgtagacgatcacgt	12	12	4	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr4:40440352C>T	uc003gvc.2	-	4	1269	c.559G>A	c.(559-561)GCG>ACG	p.A187T	RBM47_uc003gvd.2_Missense_Mutation_p.A187T|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.A149T|RBM47_uc003gvg.1_Missense_Mutation_p.A187T	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	187	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						TTGTCGGCCGCGCTGGCGTAG	0.637													T	40440352	T	T	40440352	3	4	206	1	0	0	0	0	1	0	0	0	13141	768	27	1	1238	1	RBM47	4	40440352	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	4271708	40440352	150713924	21	14472											
TMEM150C	441027	broad.mit.edu	37	chr4	83417295	83417295	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tccactaatattcagccacgGgtttaaaaccttcggtttca	6	11	2	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr4:83417295G>T	uc003hmy.1	-	6	367	c.289C>A	c.(289-291)CCG>ACG	p.P97T	TMEM150C_uc011ccj.1_Missense_Mutation_p.P127T	NM_001080506	NP_001073975	B9EJG8	T150C_HUMAN	transmembrane protein 150C	97						integral to membrane				ovary(1)	1						TTCAGCCACGGGTTTAAAACC	0.418													T	83417295	T	T	83417295	3	4	206	1	0	0	0	0	1	0	0	0	16066	1232	43	5	472	5	TMEM150C	4	83417295	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	42976943	83417295	107736981	22	14473											
ENPEP	2028	broad.mit.edu	37	chr4	111430927	111430927	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcctcatcaaaccaacagagGgtggccactgtggttgccca	11	13	2	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr4:111430927G>T	uc003iab.3	+	5	1500	c.1158G>T	c.(1156-1158)AGG>AGT	p.R386S		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	386	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ACCAACAGAGGGTGGCCACTG	0.453													T	111430927	T	T	111430927	3	4	206	1	0	0	0	0	1	0	0	0	5128	1223	43	5	1176	5	ENPEP	4	111430927	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	28013632	111430927	79723349	23	14474											
ALPK1	80216	broad.mit.edu	37	chr4	113353567	113353567	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcctatctgaattccagtgGgagttcttgggtttcattgc	11	8	3	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr4:113353567G>A	uc003iap.3	+	11	3143	c.2864G>A	c.(2863-2865)GGG>GAG	p.G955E	ALPK1_uc003ian.3_Missense_Mutation_p.G955E|ALPK1_uc011cfx.1_Missense_Mutation_p.G877E|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Missense_Mutation_p.G783E	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	955	Ser-rich.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AATTCCAGTGGGAGTTCTTGG	0.512													A	113353567	A	A	113353567	3	1	206	1	0	0	0	0	1	0	0	0	544	1232	43	3	2898	3	ALPK1	4	113353567	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	1922640	113353567	77800709	24	14475											
PPID	5481	broad.mit.edu	37	chr4	159638287	159638287	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggagttggaactgttgtgatAaaaaactgagaaccgtttgt	12	4	0	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr4:159638287A>C	uc003iqc.2	-	4	511	c.399T>G	c.(397-399)TTT>TTG	p.F133L		NM_005038	NP_005029	Q08752	PPID_HUMAN	peptidylprolyl isomerase D	133	PPIase cyclophilin-type.				protein folding	cytoplasm|intermediate filament cytoskeleton	cyclosporin A binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0159)		CTGTTGTGATAAAAAACTGAG	0.403													C	159638287	C	C	159638287	3	2	206	1	0	0	0	0	1	0	0	0	12321	359	13	5	741	5	PPID	4	159638287	Missense_Mutation	SNP	A	TCGA-28-2513-01A-01D-1494-08	46284720	159638287	31515989	25	14476											
TUBB4Q	56604	broad.mit.edu	37	chr4	190903815	190903815	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtggaggaaggccttgcGcctgaacgttgctgtaaact	13	10	0	1	rs17799221		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr4:190903815G>A	uc011clg.1	-	4	1168	c.1165C>T	c.(1165-1167)CGC>TGC	p.R389C		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	390					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		AAGGCCTTGCGCCTGAACGTT	0.547													A	190903815	A	A	190903815	3	1	206	1	0	0	0	0	1	0	0	0	16756	1087	38	1	139	1	TUBB4Q	4	190903815	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	31265528	190903815	250461	26	14477											
PIK3R1	5295	broad.mit.edu	37	chr5	67591085	67591085	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cagctgagtatcgagaaattGacaaacgtatgaacagcatt	9	7	0	4			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr5:67591085G>C	uc003jva.2	+	13	2238	c.1678G>C	c.(1678-1680)GAC>CAC	p.D560H	PIK3R1_uc003jvb.2_Missense_Mutation_p.D560H|PIK3R1_uc003jvc.2_Missense_Mutation_p.D260H|PIK3R1_uc003jvd.2_Missense_Mutation_p.D290H|PIK3R1_uc003jve.2_Missense_Mutation_p.D239H|PIK3R1_uc011crb.1_Missense_Mutation_p.D230H	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	560					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D560_S565del(1)|p.R557_K561>Q(1)|p.D560Y(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TCGAGAAATTGACAAACGTAT	0.358			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			C	67591085	C	C	67591085	3	2	206	1	0	0	0	0	1	0	0	0	11918	1290	45	5	1854	5	PIK3R1	5	67591085	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08		67591085	113324175	27	14478											
MCTP1	79772	broad.mit.edu	37	chr5	94288921	94288921	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaacaaataaatggctcAcctttatatacaatggctcc	4	9	1	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr5:94288921A>G	uc003kkx.2	-	3	981	c.981_splice	c.e3+1	p.K327_splice	MCTP1_uc003kkv.2_Splice_Site_p.K106_splice|MCTP1_uc003kkw.2_Splice_Site_p.K106_splice|MCTP1_uc003kkz.2_Splice_Site	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TAAATGGCTCACCTTTATATA	0.363													G	94288921	G	G	94288921	5	3	206	1	0	0	0	0	0	0	1	0	9400	173	6	4	2100	4	MCTP1	5	94288921	Splice_Site	SNP	A	TCGA-28-2513-01A-01D-1494-08	26697836	94288921	86626339	28	14479											
YIPF5	81555	broad.mit.edu	37	chr5	143540055	143540055	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatggctaatgcagaaataAatattttggaagcagaaaaa	8	5	0	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr5:143540055A>C	uc003lnk.3	-	6	1121	c.680T>G	c.(679-681)TTT>TGT	p.F227C	YIPF5_uc003lnl.3_Missense_Mutation_p.F227C|YIPF5_uc010jgl.2_Missense_Mutation_p.F173C	NM_001024947	NP_001020118	Q969M3	YIPF5_HUMAN	Yip1 domain family, member 5	227	Cytoplasmic (Potential).				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi cisterna membrane|integral to membrane				ovary(1)|skin(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TGCAGAAATAAATATTTTGGA	0.388													C	143540055	C	C	143540055	3	2	206	1	0	0	0	0	1	0	0	0	17478	14	1	5	97	5	YIPF5	5	143540055	Missense_Mutation	SNP	A	TCGA-28-2513-01A-01D-1494-08	49251134	143540055	37375205	29	14480											
FAT2	2196	broad.mit.edu	37	chr5	150921921	150921921	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctttagagtcgccaccagttCgccaggctcactgttctcaa	8	14	2	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr5:150921921C>T	uc003lue.3	-	9	8780	c.8767G>A	c.(8767-8769)GAA>AAA	p.E2923K	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2923	Extracellular (Potential).|Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCCACCAGTTCGCCAGGCTCA	0.512													T	150921921	T	T	150921921	3	4	206	1	0	0	0	0	1	0	0	0	5690	893	31	2	4342	2	FAT2	5	150921921	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	7381866	150921921	29993339	30	14481											
BTN3A2	11118	broad.mit.edu	37	chr6	26373202	26373202	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttgctgctgcttctcgccGgagccagttacttcttgtgg	11	12	3	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr6:26373202G>A	uc010jqh.1	+	6	1052	c.793G>A	c.(793-795)GGA>AGA	p.G265R	BTN3A2_uc003nho.1_Missense_Mutation_p.G263R|BTN3A2_uc003nhp.2_Missense_Mutation_p.G265R|BTN3A2_uc011dkd.1_Missense_Mutation_p.G223R|BTN3A2_uc011dke.1_Missense_Mutation_p.G242R|BTN3A2_uc010jqi.1_Missense_Mutation_p.G263R	NM_007047	NP_008978	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2 precursor	265	Helical; (Potential).					integral to membrane					0						GCTTCTCGCCGGAGCCAGTTA	0.542													A	26373202	A	A	26373202	3	1	206	1	0	0	0	0	1	0	0	0	1563	1117	39	2	807	2	BTN3A2	6	26373202	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08		26373202	144741865	31	14482											
PRSS35	167681	broad.mit.edu	37	chr6	84234218	84234218	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggttcgggggtctatctgcGtctgaaagatccagacaaaa	12	9	3	3			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr6:84234218G>A	uc003pjz.2	+	2	1221	c.1058G>A	c.(1057-1059)CGT>CAT	p.R353H	PRSS35_uc010kbm.2_Missense_Mutation_p.R353H	NM_153362	NP_699193	Q8N3Z0	PRS35_HUMAN	protease, serine, 35 precursor	353	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		GTCTATCTGCGTCTGAAAGAT	0.512													A	84234218	A	A	84234218	3	1	206	1	0	0	0	0	1	0	0	0	12624	1145	40	1	1060	1	PRSS35	6	84234218	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	57861016	84234218	86880849	32	14483											
REPS1	85021	broad.mit.edu	37	chr6	139251126	139251126	+	Frame_Shift_Del	DEL	A	-	-													ttgctaacctcactgctctgAttcagctcaggccatgtctg							TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr6:139251126delA	uc003qii.2	-	9	1824	c.1245delT	c.(1243-1245)AATfs	p.N415fs	REPS1_uc003qig.3_Frame_Shift_Del_p.N415fs|REPS1_uc011edr.1_Frame_Shift_Del_p.N415fs|REPS1_uc003qij.2_Frame_Shift_Del_p.N415fs|REPS1_uc003qik.2_Frame_Shift_Del_p.N48fs	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	415						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		CACTGCTCTGATTCAGCTCAG	0.448													-	139251126	-	-	139251126	7	5	206	1	0	1	0	1	0	0	0	0	13228	330	12	0	1193	0	REPS1	6	139251126	Frame_Shift_Del	DEL	A	TCGA-28-2513-01A-01D-1494-08	55016908	139251126	31863941	33	14484											
OPRM1	4988	broad.mit.edu	37	chr6	154412222	154412222	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctatggactgatgatcttgcGcctcaagagtgtccgcatgc	11	11	2	3	rs1799974		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr6:154412222G>A	uc003qpr.2	+	3	1016	c.779G>A	c.(778-780)CGC>CAC	p.R260H	OPRM1_uc011efc.1_Missense_Mutation_p.R179H|OPRM1_uc011efd.1_Missense_Mutation_p.R160H|OPRM1_uc011efe.1_Missense_Mutation_p.R353H|OPRM1_uc003qpn.2_Missense_Mutation_p.R260H|OPRM1_uc003qpo.1_Missense_Mutation_p.R260H|OPRM1_uc011eff.1_Missense_Mutation_p.R260H|OPRM1_uc011efg.1_Missense_Mutation_p.R260H|OPRM1_uc011efh.1_Missense_Mutation_p.R260H|OPRM1_uc003qpq.1_Missense_Mutation_p.R260H|OPRM1_uc003qpt.1_Missense_Mutation_p.R260H|OPRM1_uc011efi.1_Missense_Mutation_p.R260H|OPRM1_uc003qpp.2_RNA|OPRM1_uc003qps.2_RNA|OPRM1_uc010kjg.2_Missense_Mutation_p.R160H|OPRM1_uc003qpu.2_Missense_Mutation_p.R160H	NM_000914	NP_000905	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1	260	Cytoplasmic (Potential).				behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	ATGATCTTGCGCCTCAAGAGT	0.502													A	154412222	A	A	154412222	3	1	206	1	0	0	0	0	1	0	0	0	10887	1087	38	1	1123	1	OPRM1	6	154412222	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	15161096	154412222	16702845	34	14485											
RABGEF1	27342	broad.mit.edu	37	chr7	66240254	66240254	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggcctttgccagcagtcagAgcagccaaggggcccaatcc	12	14	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr7:66240254A>T	uc011kee.1	+	3	426	c.262A>T	c.(262-264)AGC>TGC	p.S88C	RABGEF1_uc003tvf.2_5'UTR|RABGEF1_uc003tvg.2_5'UTR|RABGEF1_uc010lag.2_Missense_Mutation_p.S74C|RABGEF1_uc003tvh.2_Missense_Mutation_p.S74C|RABGEF1_uc003tvi.2_5'UTR	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	252	Interaction with ubiquitinated proteins.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						CAGCAGTCAGAGCAGCCAAGG	0.473													T	66240254	T	T	66240254	3	4	206	1	0	0	0	0	1	0	0	0	12966	304	11	5	226	5	RABGEF1	7	66240254	Missense_Mutation	SNP	A	TCGA-28-2513-01A-01D-1494-08		66240254	92898409	35	14486											
PPP1R3A	5506	broad.mit.edu	37	chr7	113519322	113519322	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accagttatccctcctaaagCgctgccttcactagtcaaat	5	14	2	0	rs144397367		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr7:113519322C>T	uc010ljy.1	-	4	1856	c.1825G>A	c.(1825-1827)GCT>ACT	p.A609T		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	609					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						CCTCCTAAAGCGCTGCCTTCA	0.403													T	113519322	T	T	113519322	3	4	206	1	0	0	0	0	1	0	0	0	12371	768	27	1	1547	1	PPP1R3A	7	113519322	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	47279068	113519322	45619341	36	14487											
ZNF786	136051	broad.mit.edu	37	chr7	148769373	148769373	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatttctgggacctgggattCcttcttttagggtagattca	11	7	3	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr7:148769373C>T	uc003wfh.2	-	4	628	c.491G>A	c.(490-492)GGA>GAA	p.G164E	ZNF786_uc011kuk.1_Missense_Mutation_p.G127E|ZNF786_uc003wfi.2_Missense_Mutation_p.G78E	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			ACCTGGGATTCCTTCTTTTAG	0.617													T	148769373	T	T	148769373	3	4	206	1	0	0	0	0	1	0	0	0	18155	855	30	3	1861	3	ZNF786	7	148769373	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	35250051	148769373	10369290	37	14488											
KRBA1	84626	broad.mit.edu	37	chr7	149427522	149427522	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtttgtgacgttagagagGgaccgccttcccagctgtaa	12	9	0	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr7:149427522G>A	uc003wfz.2	+	16	2409	c.2010G>A	c.(2008-2010)AGG>AGA	p.R670R	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Silent_p.R277R	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	670	Pro-rich.									ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGTTAGAGAGGGACCGCCTTC	0.642													A	149427522	A	A	149427522	2	1	206	1	0	0	0	0	0	0	0	1	8439	1223	43	3		3	KRBA1	7	149427522	Silent	SNP	G	TCGA-28-2513-01A-01D-1494-08	658149	149427522	9711141	38	14489											
NSMAF	8439	broad.mit.edu	37	chr8	59512581	59512581	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttccaagtttctgcaataCtacatatgaaaaaaaaattc	3	7	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr8:59512581C>T	uc003xtt.2	-	17	1495	c.1281_splice	c.e17-1	p.S427_splice	NSMAF_uc011lee.1_Splice_Site_p.S458_splice	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation						ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				TTCTGCAATACTACATATGAA	0.269													T	59512581	T	T	59512581	5	4	206	1	0	0	0	0	0	0	1	0	10674	579	20	3	1533	3	NSMAF	8	59512581	Splice_Site	SNP	C	TCGA-28-2513-01A-01D-1494-08		59512581	86851441	39	14490											
PKHD1L1	93035	broad.mit.edu	37	chr8	110497284	110497284	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttttctaaggagggagaagaGattgtgataacaaccacaag	11	5	1	3			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr8:110497284G>A	uc003yne.2	+	58	9692	c.9588G>A	c.(9586-9588)GAG>GAA	p.E3196E		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3196	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGGGAGAAGAGATTGTGATAA	0.284										HNSCC(38;0.096)			A	110497284	A	A	110497284	2	1	206	1	0	0	0	0	0	0	0	1	11972	933	33	3		3	PKHD1L1	8	110497284	Silent	SNP	G	TCGA-28-2513-01A-01D-1494-08	50984703	110497284	35866738	40	14491											
TRPS1	7227	broad.mit.edu	37	chr8	116426785	116426785	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agccaatcagcttcactctgGaagtcattatgtacaaaggg	9	9	4	0	rs145393309		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr8:116426785G>T	uc003ynz.2	-	6	3771	c.3312C>A	c.(3310-3312)TTC>TTA	p.F1104L	TRPS1_uc011lhy.1_Missense_Mutation_p.F1108L|TRPS1_uc003yny.2_Missense_Mutation_p.F1117L|TRPS1_uc010mcy.2_Missense_Mutation_p.F1104L	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	1104	Mediates interaction with RNF4 (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.F1104F(1)		ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTTCACTCTGGAAGTCATTAT	0.473									Langer-Giedion_syndrome				T	116426785	T	T	116426785	3	4	206	1	0	0	0	0	1	0	0	0	16590	1165	41	5	537	5	TRPS1	8	116426785	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	5929501	116426785	29937237	41	14492											
COL14A1	7373	broad.mit.edu	37	chr8	121293282	121293282	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactccataaagatgccctgGtttcccagccaaccaggtat	7	13	0	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr8:121293282G>A	uc003yox.2	+	31	4073	c.3808G>A	c.(3808-3810)GTT>ATT	p.V1270I	COL14A1_uc003yoz.2_Missense_Mutation_p.V235I	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1270	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AGATGCCCTGGTTTCCCAGCC	0.378													A	121293282	A	A	121293282	3	1	206	1	0	0	0	0	1	0	0	0	3671	1261	44	3	3926	3	COL14A1	8	121293282	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	4866497	121293282	25070740	42	14493											
PTEN	5728	broad.mit.edu	37	chr10	89693009	89693009	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	taaggaccagagacaaaaagGtaagttattttttgatgttt	9	3	0	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr10:89693009G>T	uc001kfb.2	+	6	1523	c.492_splice	c.e6+1	p.K164_splice		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.Y27fs*1(2)|p.?(2)|p.K163_V166>NKGE(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGACAAAAAGGTAAGTTATTT	0.313		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89693009	T	T	89693009	5	4	206	1	0	0	0	0	0	0	1	0	12738	1275	44	5	511	5	PTEN	10	89693009	Splice_Site	SNP	G	TCGA-28-2513-01A-01D-1494-08		89693009	45841738	43	14494											
PIK3AP1	118788	broad.mit.edu	37	chr10	98411291	98411291	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatgaattccacaggattcGcggcattggacaataaattc	8	9	0	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr10:98411291G>A	uc001kmq.2	-	5	958	c.830C>T	c.(829-831)GCG>GTG	p.A277V	PIK3AP1_uc001kmp.2_Missense_Mutation_p.A99V	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	277	DBB.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CACAGGATTCGCGGCATTGGA	0.398													A	98411291	A	A	98411291	3	1	206	1	0	0	0	0	1	0	0	0	11908	1087	38	1	1639	1	PIK3AP1	10	98411291	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	8718282	98411291	37123456	44	14495											
CNGA4	1262	broad.mit.edu	37	chr11	6261464	6261464	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgaaccgctttctccgcgCgccccgcctcttcgaggcct	10	19	2	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr11:6261464C>T	uc001mco.2	+	4	547	c.440C>T	c.(439-441)GCG>GTG	p.A147V	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.A107V	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	147	Extracellular (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTTCTCCGCGCGCCCCGCCTC	0.587													T	6261464	T	T	6261464	3	4	206	1	0	0	0	0	1	0	0	0	3599	768	27	1	454	1	CNGA4	11	6261464	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08		6261464	128745052	45	14496											
OR5D14	219436	broad.mit.edu	37	chr11	55563770	55563770	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctccacctgggcctcccacCtgacttctatcaccatcttc	4	19	4	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr11:55563770C>A	uc010rim.1	+	1	739	c.739C>A	c.(739-741)CTG>ATG	p.L247M		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				GGCCTCCCACCTGACTTCTAT	0.453													A	55563770	A	A	55563770	3	1	206	1	0	0	0	0	1	0	0	0	11155	680	24	5	741	5	OR5D14	11	55563770	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	49302306	55563770	79442746	46	14497											
DDI1	414301	broad.mit.edu	37	chr11	103908142	103908142	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccttgagagagcaagagaggCttcgtctctacacagccgac	11	12	1	3			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr11:103908142C>G	uc001phr.2	+	1	835	c.592C>G	c.(592-594)CTT>GTT	p.L198V	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	198					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GCAAGAGAGGCTTCGTCTCTA	0.522													G	103908142	G	G	103908142	3	3	206	1	0	0	0	0	1	0	0	0	4328	797	28	5	594	5	DDI1	11	103908142	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	48344372	103908142	31098374	47	14498											
OR8A1	390275	broad.mit.edu	37	chr11	124440263	124440263	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cattacccctaagatgctggTgaactttgtgtcagagaaaa	9	8	1	3			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr11:124440263T>A	uc010san.1	+	1	299	c.299T>A	c.(298-300)GTG>GAG	p.V100E		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	100	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		AAGATGCTGGTGAACTTTGTG	0.463													A	124440263	A	A	124440263	3	1	206	1	0	0	0	0	1	0	0	0	11225	1696	59	5	301	5	OR8A1	11	124440263	Missense_Mutation	SNP	T	TCGA-28-2513-01A-01D-1494-08	20532121	124440263	10566253	48	14499											
ANKRD33	341405	broad.mit.edu	37	chr12	52284606	52284606	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cggctgcaggctaccttgagCctcccctttgccccgtctcc	9	19	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr12:52284606C>A	uc001rzf.3	+	5	1080	c.501C>A	c.(499-501)AGC>AGA	p.S167R	ANKRD33_uc001rzh.3_3'UTR|ANKRD33_uc001rzd.2_Missense_Mutation_p.S292R|ANKRD33_uc001rze.2_Missense_Mutation_p.S188R|ANKRD33_uc001rzg.3_Missense_Mutation_p.S94R|ANKRD33_uc001rzi.3_Missense_Mutation_p.S167R	NM_001130015	NP_001123487	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33 isoform 1	167											0				BRCA - Breast invasive adenocarcinoma(357;0.0969)		CTACCTTGAGCCTCCCCTTTG	0.557													A	52284606	A	A	52284606	3	1	206	1	0	0	0	0	1	0	0	0	661	738	26	5	924	5	ANKRD33	12	52284606	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08		52284606	81567289	49	14500											
OR6C3	254786	broad.mit.edu	37	chr12	55726370	55726370	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgagaaaccagcaagtaaaaCaagccttcaaaaatgtggtc	8	8	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr12:55726370C>A	uc010spj.1	+	1	886	c.886C>A	c.(886-888)CAA>AAA	p.Q296K		NM_054104	NP_473445	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCAAGTAAAACAAGCCTTCAA	0.338													A	55726370	A	A	55726370	3	1	206	1	0	0	0	0	1	0	0	0	11192	479	17	5	888	5	OR6C3	12	55726370	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	3441764	55726370	78125525	50	14501											
PTPRB	5787	broad.mit.edu	37	chr12	70933755	70933755	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttaagtggacagataatggtCgatccctacgaatgctcaga	10	8	1	2	rs139546127	by1000genomes	TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr12:70933755C>T	uc001swb.3	-	22	5018	c.4988G>A	c.(4987-4989)CGA>CAA	p.R1663Q	PTPRB_uc010sto.1_Missense_Mutation_p.R1573Q|PTPRB_uc010stp.1_Missense_Mutation_p.R1573Q|PTPRB_uc001swc.3_Missense_Mutation_p.R1881Q|PTPRB_uc001swa.3_Missense_Mutation_p.R1793Q	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1663	Cytoplasmic (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGATAATGGTCGATCCCTACG	0.413													T	70933755	T	T	70933755	3	4	206	1	0	0	0	0	1	0	0	0	12796	884	31	2	1049	2	PTPRB	12	70933755	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	15207385	70933755	62918140	51	14502											
PTPRR	5801	broad.mit.edu	37	chr12	71286587	71286587	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaattgacaatctggtggcGtttgcttacttgagcttcgg	12	7	1	3			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr12:71286587G>A	uc001swi.1	-	2	645	c.229C>T	c.(229-231)CGC>TGC	p.R77C		NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	77	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		ATCTGGTGGCGTTTGCTTACT	0.448													A	71286587	A	A	71286587	3	1	206	1	0	0	0	0	1	0	0	0	12810	1145	40	1	1796	1	PTPRR	12	71286587	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	352832	71286587	62565308	52	14503											
C12orf63	374467	broad.mit.edu	37	chr12	97073486	97073486	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ataccataacagatcaatccGacacagcagaaagttgcttt	6	10	1	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr12:97073486G>A	uc001tet.1	+	7	1025	c.947G>A	c.(946-948)CGA>CAA	p.R316Q		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	316										skin(6)|ovary(1)	7						AGATCAATCCGACACAGCAGA	0.453													A	97073486	A	A	97073486	3	1	206	1	0	0	0	0	1	0	0	0	1706	1058	37	2	969	2	C12orf63	12	97073486	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	25786899	97073486	36778409	53	14504											
OASL	8638	broad.mit.edu	37	chr12	121465457	121465457	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agtacttggtccagtagataCagatgacttcatactccagg	9	9	1	3			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr12:121465457C>G	uc001tzj.1	-	4	827	c.821G>C	c.(820-822)TGT>TCT	p.C274S	OASL_uc001tzk.1_Intron	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	274					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCAGTAGATACAGATGACTTC	0.453													G	121465457	G	G	121465457	3	3	206	1	0	0	0	0	1	0	0	0	10802	478	17	5	735	5	OASL	12	121465457	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	24391971	121465457	12386438	54	14505											
EP400	57634	broad.mit.edu	37	chr12	132512816	132512816	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcggtgtggagagtctctGcaggatgttattgacaggta	15	5	1	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr12:132512816G>A	uc001ujn.2	+	26	5399	c.5364G>A	c.(5362-5364)CTG>CTA	p.L1788L	EP400_uc001ujl.2_Silent_p.L1787L|EP400_uc001ujm.2_Silent_p.L1707L	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1824					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GAGAGTCTCTGCAGGATGTTA	0.557													A	132512816	A	A	132512816	2	1	206	1	0	0	0	0	0	0	0	1	5149	1306	46	3		3	EP400	12	132512816	Silent	SNP	G	TCGA-28-2513-01A-01D-1494-08	11047359	132512816	1339079	55	14506											
KCNK10	54207	broad.mit.edu	37	chr14	88652226	88652226	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgctccggccccttcaggcGcaggttgttgggccggttgt	15	13	1	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr14:88652226G>A	uc001xwo.2	-	7	1727	c.1270C>T	c.(1270-1272)CGC>TGC	p.R424C	KCNK10_uc001xwm.2_Missense_Mutation_p.R429C|KCNK10_uc001xwn.2_Missense_Mutation_p.R429C	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	424	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						CCCTTCAGGCGCAGGTTGTTG	0.607													A	88652226	A	A	88652226	3	1	206	1	0	0	0	0	1	0	0	0	8059	1087	38	1	350	1	KCNK10	14	88652226	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08		88652226	18697314	56	14507											
MTMR15	22909	broad.mit.edu	37	chr15	31197005	31197005	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctaaacttgcctgccccgttTgcagtaaaatggtgcctaga	9	11	0	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr15:31197005T>C	uc001zff.2	+	2	430	c.139T>C	c.(139-141)TGC>CGC	p.C47R	MTMR15_uc001zfc.3_Missense_Mutation_p.C47R|MTMR15_uc010azw.2_Missense_Mutation_p.C47R|MTMR15_uc001zfd.3_Missense_Mutation_p.C47R|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	47	UBZ-type.			C->A: Abolishes interaction with monoubiquitinated FANCD2; when associated with A-44.	double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		CTGCCCCGTTTGCAGTAAAAT	0.403								Direct_reversal_of_damage|Editing_and_processing_nucleases					C	31197005	C	C	31197005	3	2	206	1	0	0	0	0	1	0	0	0	9943	1812	63	4	141	4	MTMR15	15	31197005	Missense_Mutation	SNP	T	TCGA-28-2513-01A-01D-1494-08		31197005	71334387	57	14508											
AXIN1	8312	broad.mit.edu	37	chr16	339599	339599	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgccgcccaccttcctctgcGatcttgtcctggggaaagag	11	15	2	1	rs138816818		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr16:339599G>T	uc002cgp.1	-	10	2480	c.2303C>A	c.(2302-2304)TCG>TAG	p.S768*	AXIN1_uc002cgq.1_Nonsense_Mutation_p.S732*	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	768	Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CTTCCTCTGCGATCTTGTCCT	0.637													T	339599	T	T	339599	4	4	206	1	0	0	0	0	0	1	0	0	1236	1059	37	5	293	5	AXIN1	16	339599	Nonsense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08		339599	90015154	58	14509											
ATF7IP2	80063	broad.mit.edu	37	chr16	10534246	10534246	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatagcaaaacttcaaagacGtattaaaacagtattattat	4	5	1	1	rs141687995		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr16:10534246G>A	uc002czu.2	+	6	1348	c.1121G>A	c.(1120-1122)CGT>CAT	p.R374H	ATF7IP2_uc002czv.2_Missense_Mutation_p.R374H|ATF7IP2_uc010uyo.1_RNA|ATF7IP2_uc010uyp.1_Intron|ATF7IP2_uc002czw.2_Missense_Mutation_p.R374H|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	374	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						CTTCAAAGACGTATTAAAACA	0.289													A	10534246	A	A	10534246	3	1	206	1	0	0	0	0	1	0	0	0	1088	1145	40	1	1135	1	ATF7IP2	16	10534246	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	10194647	10534246	79820507	59	14510											
ACSM5	54988	broad.mit.edu	37	chr16	20442617	20442617	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgtatcagacccactcggCccttctgtttcttcaattgc	6	15	4	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr16:20442617C>T	uc002dhe.2	+	10	1429	c.1282C>T	c.(1282-1284)CCC>TCC	p.P428S		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	428					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						ACCCACTCGGCCCTTCTGTTT	0.413													T	20442617	T	T	20442617	3	4	206	1	0	0	0	0	1	0	0	0	187	739	26	3	1316	3	ACSM5	16	20442617	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	9908371	20442617	69912136	60	14511											
ITGAM	3684	broad.mit.edu	37	chr16	31308873	31308873	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctccctctgctccgtggaCgtggacagcaacggcagcac	12	16	1	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr16:31308873C>T	uc002ebq.2	+	13	1493	c.1395C>T	c.(1393-1395)GAC>GAT	p.D465D	ITGAM_uc002ebr.2_Silent_p.D465D|ITGAM_uc010cam.1_Missense_Mutation_p.R69C|ITGAM_uc010can.2_Translation_Start_Site	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	465	FG-GAP 5.|Extracellular (Potential).|Potential.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GCTCCGTGGACGTGGACAGCA	0.627													T	31308873	T	T	31308873	2	4	206	1	0	0	0	0	0	0	0	1	7887	535	19	1		1	ITGAM	16	31308873	Silent	SNP	C	TCGA-28-2513-01A-01D-1494-08	10866256	31308873	59045880	61	14512											
ZFHX3	463	broad.mit.edu	37	chr16	72821854	72821854	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tttgctttctgcttctggctCttcagggagtttcggcagga	12	9	4	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr16:72821854C>A	uc002fck.2	-	10	10994	c.10321G>T	c.(10321-10323)GAG>TAG	p.E3441*	ZFHX3_uc002fcl.2_Nonsense_Mutation_p.E2527*	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3441					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GCTTCTGGCTCTTCAGGGAGT	0.557													A	72821854	A	A	72821854	4	1	206	1	0	0	0	0	0	1	0	0	17631	922	32	5	794	5	ZFHX3	16	72821854	Nonsense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	41512981	72821854	17532899	62	14513											
MYH1	4619	broad.mit.edu	37	chr17	10399320	10399320	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccaggagctcctgttctgCgattttcctgctcctctctg	8	14	2	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr17:10399320C>T	uc002gmo.2	-	35	5210	c.5116G>A	c.(5116-5118)GCA>ACA	p.A1706T	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1706	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCCTGTTCTGCGATTTTCCTG	0.532													T	10399320	T	T	10399320	3	4	206	1	0	0	0	0	1	0	0	0	10029	768	27	1	727	1	MYH1	17	10399320	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08		10399320	70795890	63	14514											
MYH2	4620	broad.mit.edu	37	chr17	10427956	10427956	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcaggtcctcctggctccGgagagcatcatccaggtgga	12	13	2	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr17:10427956G>A	uc010coi.2	-	35	5130	c.5002C>T	c.(5002-5004)CGG>TGG	p.R1668W	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1668W|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1668	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCCTGGCTCCGGAGAGCATCA	0.572													A	10427956	A	A	10427956	3	1	206	1	0	0	0	0	1	0	0	0	10035	1115	39	2	847	2	MYH2	17	10427956	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	28636	10427956	70767254	64	14515											
ACACA	31	broad.mit.edu	37	chr17	35615262	35615262	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cccatacatcatacggatatCcttgattctatatagaggaa	6	9	2	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr17:35615262C>G	uc002hnm.2	-	13	1614	c.1423G>C	c.(1423-1425)GAT>CAT	p.D475H	ACACA_uc002hnk.2_Missense_Mutation_p.D397H|ACACA_uc002hnl.2_Missense_Mutation_p.D417H|ACACA_uc002hnn.2_Missense_Mutation_p.D475H|ACACA_uc002hno.2_Missense_Mutation_p.D512H|ACACA_uc010cuz.2_Missense_Mutation_p.D475H	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	475	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ATACGGATATCCTTGATTCTA	0.413													G	35615262	G	G	35615262	3	3	206	1	0	0	0	0	1	0	0	0	106	855	30	5	5793	5	ACACA	17	35615262	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	25187306	35615262	45579948	65	14516											
MKS1	54903	broad.mit.edu	37	chr17	56294074	56294074	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aatcacaatctcctcctcttCgtcttcctctgggcggtgtc	7	15	5	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr17:56294074C>T	uc002ivr.1	-	3	289	c.214G>A	c.(214-216)GAA>AAA	p.E72K	MKS1_uc010wnq.1_5'UTR|MKS1_uc002ivs.1_Missense_Mutation_p.E72K	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	72					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						TCCTCCTCTTCGTCTTCCTCT	0.483													T	56294074	T	T	56294074	3	4	206	1	0	0	0	0	1	0	0	0	9609	893	31	2	1529	2	MKS1	17	56294074	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	20678812	56294074	24901136	66	14517											
CDR2L	30850	broad.mit.edu	37	chr17	73000053	73000053	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgtggaggccgtggacaagCggctggaacagagccagccc	16	12	0	1	rs144796205	byFrequency	TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr17:73000053C>T	uc002jml.3	+	5	1694	c.1282C>T	c.(1282-1284)CGG>TGG	p.R428W		NM_014603	NP_055418	Q86X02	CDR2L_HUMAN	cerebellar degeneration-related protein 2-like	428											0	all_lung(278;0.226)					CGTGGACAAGCGGCTGGAACA	0.612													T	73000053	T	T	73000053	3	4	206	1	0	0	0	0	1	0	0	0	3173	759	27	1	1300	1	CDR2L	17	73000053	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	16705979	73000053	8195157	67	14518											
ITGB4	3691	broad.mit.edu	37	chr17	73725429	73725429	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagatgtggatgagttccGgaataaactgcagggagagc	15	5	0	4	rs144968507		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr17:73725429G>A	uc002jpg.2	+	7	837	c.650G>A	c.(649-651)CGG>CAG	p.R217Q	ITGB4_uc002jph.2_Missense_Mutation_p.R217Q|ITGB4_uc010dgo.2_Missense_Mutation_p.R217Q|ITGB4_uc002jpi.3_Missense_Mutation_p.R217Q|ITGB4_uc010dgp.1_Missense_Mutation_p.R217Q|ITGB4_uc002jpj.2_Missense_Mutation_p.R217Q|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	217	VWFA.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GATGAGTTCCGGAATAAACTG	0.602													A	73725429	A	A	73725429	3	1	206	1	0	0	0	0	1	0	0	0	7897	1116	39	2	672	2	ITGB4	17	73725429	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	725376	73725429	7469781	68	14519											
ROCK1	6093	broad.mit.edu	37	chr18	18547745	18547745	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	attcagttccttctgatgttTcactaccatctggttgaatt	6	9	4	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr18:18547745T>A	uc002kte.2	-	26	4101	c.3160A>T	c.(3160-3162)AAA>TAA	p.K1054*		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1054	Potential.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TTCTGATGTTTCACTACCATC	0.353													A	18547745	A	A	18547745	4	1	206	1	0	0	0	0	0	1	0	0	13517	1792	62	5	936	5	ROCK1	18	18547745	Nonsense_Mutation	SNP	T	TCGA-28-2513-01A-01D-1494-08		18547745	59529503	69	14520											
CTAGE1	64693	broad.mit.edu	37	chr18	19996798	19996798	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atgcttgttcagtctgaagaTttttaatatgctctgtaagc	8	6	3	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr18:19996798T>A	uc002ktv.1	-	1	1081	c.977A>T	c.(976-978)AAT>ATT	p.N326I		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	326	Potential.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGTCTGAAGATTTTTAATATG	0.308													A	19996798	A	A	19996798	3	1	206	1	0	0	0	0	1	0	0	0	3992	1493	52	5	1264	5	CTAGE1	18	19996798	Missense_Mutation	SNP	T	TCGA-28-2513-01A-01D-1494-08	1449053	19996798	58080450	70	14521											
DSC2	1824	broad.mit.edu	37	chr18	28673541	28673541	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctctaccaacaagtttctcGgcatctagtttggagggaac	9	11	3	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr18:28673541G>A	uc002kwl.3	-	2	589	c.135C>T	c.(133-135)GCC>GCT	p.A45A	DSC2_uc002kwk.3_Silent_p.A45A|DSC2_uc010xbo.1_Silent_p.A45A	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	45					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CAAGTTTCTCGGCATCTAGTT	0.259													A	28673541	A	A	28673541	2	1	206	1	0	0	0	0	0	0	0	1	4766	1103	39	2		2	DSC2	18	28673541	Silent	SNP	G	TCGA-28-2513-01A-01D-1494-08	8676743	28673541	49403707	71	14522											
SMAD4	4089	broad.mit.edu	37	chr18	48604808	48604808	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgaagtacttcataccatgCcgattgcagacccacaacct	6	14	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr18:48604808C>T	uc010xdp.1	+	12	2168	c.1630C>T	c.(1630-1632)CCG>TCG	p.P544S	SMAD4_uc002lfb.3_Missense_Mutation_p.P389S	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	544	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TCATACCATGCCGATTGCAGA	0.458									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				T	48604808	T	T	48604808	3	4	206	1	0	0	0	0	1	0	0	0	14760	739	26	3	1672	3	SMAD4	18	48604808	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	19931267	48604808	29472440	72	14523											
SERPINB4	6318	broad.mit.edu	37	chr18	61305084	61305084	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taattcgactactactacagCggtggcagctgcagcttcca	9	12	0	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr18:61305084C>T	uc002ljf.2	-	8	1128	c.1042G>A	c.(1042-1044)GCT>ACT	p.A348T	SERPINB4_uc002lje.2_Missense_Mutation_p.A327T|SERPINB4_uc002ljg.2_Missense_Mutation_p.A348T	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	348					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						ACTACTACAGCGGTGGCAGCT	0.468													T	61305084	T	T	61305084	3	4	206	1	0	0	0	0	1	0	0	0	14103	768	27	1	134	1	SERPINB4	18	61305084	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	12700276	61305084	16772164	73	14524											
FBN3	84467	broad.mit.edu	37	chr19	8190851	8190851	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaagacccagcagtgttgaCgcaacgcccgttgggacaga	13	11	0	3			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr19:8190851C>T	uc002mjf.2	-	21	2677	c.2656G>A	c.(2656-2658)GTC>ATC	p.V886I		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	886	EGF-like 11; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GCAGTGTTGACGCAACGCCCG	0.637													T	8190851	T	T	8190851	3	4	206	1	0	0	0	0	1	0	0	0	5704	536	19	1	5945	1	FBN3	19	8190851	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08		8190851	50938132	74	14525											
MUC16	94025	broad.mit.edu	37	chr19	9068764	9068764	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaaggtgaggttgtcacaaGgagaggtgcctgagaagaga	17	4	1	5			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr19:9068764G>T	uc002mkp.2	-	3	18886	c.18682C>A	c.(18682-18684)CTT>ATT	p.L6228I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6230	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTTGTCACAAGGAGAGGTGCC	0.478													T	9068764	T	T	9068764	3	4	206	1	0	0	0	0	1	0	0	0	9973	1000	35	5	25169	5	MUC16	19	9068764	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	877913	9068764	50060219	75	14526											
RTBDN	83546	broad.mit.edu	37	chr19	12939705	12939705	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggctcggcactccacagcGttctggatggtttccagggc	14	12	1	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr19:12939705G>A	uc002mvi.2	-	3	362	c.232C>T	c.(232-234)CGC>TGC	p.R78C	RTBDN_uc002mvh.1_Missense_Mutation_p.R110C|RTBDN_uc002mvj.2_Missense_Mutation_p.R110C	NM_001080997	NP_001074466	Q9BSG5	RTBDN_HUMAN	retbindin isoform 1	78						extracellular region					0						ACTCCACAGCGTTCTGGATGG	0.582													A	12939705	A	A	12939705	3	1	206	1	0	0	0	0	1	0	0	0	13717	1145	40	1	473	1	RTBDN	19	12939705	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	3870941	12939705	46189278	76	14527											
GTPBP3	84705	broad.mit.edu	37	chr19	17450006	17450006	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccaggcgcgggcagaggctcCgctcaggggtgcacgtagtg	18	12	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr19:17450006C>A	uc010eas.2	+	6	804	c.739C>A	c.(739-741)CGC>AGC	p.R247S	GTPBP3_uc010xpo.1_Missense_Mutation_p.R269S|GTPBP3_uc010ear.1_RNA|GTPBP3_uc002ngh.3_Missense_Mutation_p.R247S|GTPBP3_uc002ngg.3_Missense_Mutation_p.R279S|GTPBP3_uc002ngi.3_5'UTR	NM_032620	NP_116009	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial) isoform V	247					tRNA modification	mitochondrion	GTP binding|GTPase activity			skin(1)	1						GCAGAGGCTCCGCTCAGGGGT	0.662													A	17450006	A	A	17450006	3	1	206	1	0	0	0	0	1	0	0	0	6881	652	23	5	853	5	GTPBP3	19	17450006	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	4510301	17450006	41678977	77	14528											
UBA52	7311	broad.mit.edu	37	chr19	18684123	18684123	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acgcaaacatgcagatctttGtgaagaccctcactggcaaa	8	11	2	3			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr19:18684123G>C	uc002njr.2	+	2	127	c.13G>C	c.(13-15)GTG>CTG	p.V5L	UBA52_uc002njs.2_Missense_Mutation_p.V5L|UBA52_uc002njt.2_Missense_Mutation_p.V5L	NM_001033930	NP_001029102	P62987	RL40_HUMAN	ubiquitin and ribosomal protein L40 precursor	5	Ubiquitin-like.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome				0						GCAGATCTTTGTGAAGACCCT	0.517													C	18684123	C	C	18684123	3	2	206	1	0	0	0	0	1	0	0	0	16828	1377	48	5	15	5	UBA52	19	18684123	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	1234117	18684123	40444860	78	14529											
ZNF787	126208	broad.mit.edu	37	chr19	56614551	56614551	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctggtcctcagaatccagCggccccggagaccaggcttc	12	15	1	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr19:56614551C>T	uc010eth.1	-	2	155	c.36G>A	c.(34-36)CCG>CCA	p.P12P	ZNF787_uc002qml.1_Silent_p.P12P	NM_001002836	NP_001002836	Q6DD87	ZN787_HUMAN	zinc finger protein 787	12					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0559)		CAGAATCCAGCGGCCCCGGAG	0.632													T	56614551	T	T	56614551	2	4	206	1	0	0	0	0	0	0	0	1	18156	755	27	1		1	ZNF787	19	56614551	Silent	SNP	C	TCGA-28-2513-01A-01D-1494-08	37930428	56614551	2514432	79	14530											
ZFP28	140612	broad.mit.edu	37	chr19	57060380	57060380	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctctcaagaaggacttctgcGaaggaaagctatcccaggca	10	11	2	1	rs142184982		TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr19:57060380G>A	uc002qnj.2	+	5	648	c.577G>A	c.(577-579)GAA>AAA	p.E193K	ZFP28_uc002qni.2_Missense_Mutation_p.E193K|uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GGACTTCTGCGAAGGAAAGCT	0.413													A	57060380	A	A	57060380	3	1	206	1	0	0	0	0	1	0	0	0	17639	1059	37	2	595	2	ZFP28	19	57060380	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	445829	57060380	2068603	80	14531											
MRPS26	64949	broad.mit.edu	37	chr20	3027090	3027090	+	Frame_Shift_Del	DEL	C	-	-													ggttctggcggagcgcaaggCcctgaaggacgccgccgagc							TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr20:3027090delC	uc002whs.2	+	2	324	c.284delC	c.(283-285)GCCfs	p.A95fs		NM_030811	NP_110438	Q9BYN8	RT26_HUMAN	mitochondrial ribosomal protein S26 precursor	95					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit					0						GAGCGCAAGGCCCTGAAGGAC	0.627													-	3027090	-	-	3027090	7	5	206	1	0	1	0	1	0	0	0	0	9837	739	26	0	290	0	MRPS26	20	3027090	Frame_Shift_Del	DEL	C	TCGA-28-2513-01A-01D-1494-08		3027090	59998430	81	14532											
SNX21	90203	broad.mit.edu	37	chr20	44469563	44469563	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcgtgctgccggagctgCggcgggcacagagcctcacc	14	15	2	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr20:44469563C>T	uc002xpv.1	+	4	822	c.733C>T	c.(733-735)CGG>TGG	p.R245W	SNX21_uc002xps.1_Intron|SNX21_uc002xpt.1_3'UTR|SNX21_uc002xpu.1_3'UTR|SNX21_uc002xpw.1_Missense_Mutation_p.R56W|SNX21_uc002xpx.2_Missense_Mutation_p.R235W|SNX21_uc010zxd.1_3'UTR|SNX21_uc002xpy.1_Missense_Mutation_p.R56W|SNX21_uc002xpz.1_Missense_Mutation_p.R56W	NM_033421	NP_219489	Q969T3	SNX21_HUMAN	sorting nexin 21 isoform a	245	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			breast(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				GCCGGAGCTGCGGCGGGCACA	0.662													T	44469563	T	T	44469563	3	4	206	1	0	0	0	0	1	0	0	0	14893	759	27	1	762	1	SNX21	20	44469563	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	41442473	44469563	18555957	82	14533											
PREX1	57580	broad.mit.edu	37	chr20	47276521	47276521	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcgaagctgtttgttcttgCtgctggtcccctccatctcc	9	14	2	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr20:47276521C>T	uc002xtw.1	-	16	1840	c.1817G>A	c.(1816-1818)AGC>AAC	p.S606N		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	606					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			TTTGTTCTTGCTGCTGGTCCC	0.562													T	47276521	T	T	47276521	3	4	206	1	0	0	0	0	1	0	0	0	12476	797	28	3	3262	3	PREX1	20	47276521	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	2806958	47276521	15748999	83	14534											
TBC1D22A	25771	broad.mit.edu	37	chr22	47507479	47507479	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgagatggaggaaggaaataCtagaagaaaaagattttcaa	11	2	1	4			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chr22:47507479C>G	uc003bib.2	+	12	1540	c.1405C>G	c.(1405-1407)CTA>GTA	p.L469V	TBC1D22A_uc010haf.2_Missense_Mutation_p.L439V|TBC1D22A_uc003bic.2_Missense_Mutation_p.L410V|TBC1D22A_uc003bie.2_Missense_Mutation_p.L391V|TBC1D22A_uc003bid.2_RNA|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Missense_Mutation_p.L422V	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	469						intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		GAAGGAAATACTAGAAGAAAA	0.368													G	47507479	G	G	47507479	3	3	206	1	0	0	0	0	1	0	0	0	15608	564	20	5	1451	5	TBC1D22A	22	47507479	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08		47507479	3797087	84	14535											
POLA1	5422	broad.mit.edu	37	chrX	24766501	24766501	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattttgcccagagagatccGgaaactggtagaacggagaa	12	8	0	4			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:24766501G>A	uc004dbl.2	+	25	2770	c.2747G>A	c.(2746-2748)CGG>CAG	p.R916Q		NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	916					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	AGAGAGATCCGGAAACTGGTA	0.284													A	24766501	A	A	24766501	3	1	206	1	0	0	0	0	1	0	0	0	12187	1116	39	2	2845	2	POLA1	23	24766501	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08		24766501	130504059	85	14536											
MAGEB2	4113	broad.mit.edu	37	chrX	30236767	30236767	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggcccgagatgagacccggGgtctcaatgttcctcaggtc	13	12	2	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:30236767G>T	uc004dbz.2	+	2	173	c.70G>T	c.(70-72)GGT>TGT	p.G24C		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	24							protein binding			ovary(1)	1						TGAGACCCGGGGTCTCAATGT	0.577													T	30236767	T	T	30236767	3	4	206	1	0	0	0	0	1	0	0	0	9176	1232	43	5	72	5	MAGEB2	23	30236767	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	5470266	30236767	125033793	86	14537											
MAGEB4	4115	broad.mit.edu	37	chrX	30260607	30260607	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agacgaagatgttagtgcagTtcctgctgtacaagtataaa	10	6	0	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:30260607T>A	uc004dcb.2	+	1	439	c.355T>A	c.(355-357)TTC>ATC	p.F119I	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	119	MAGE.									ovary(1)	1						GTTAGTGCAGTTCCTGCTGTA	0.443													A	30260607	A	A	30260607	3	1	206	1	0	0	0	0	1	0	0	0	9178	1725	60	5	357	5	MAGEB4	23	30260607	Missense_Mutation	SNP	T	TCGA-28-2513-01A-01D-1494-08	23840	30260607	125009953	87	14538											
DMD	1756	broad.mit.edu	37	chrX	32404521	32404521	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctttttctgtacaatctgaCgtccagtctttatcaccatt	5	11	4	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:32404521C>T	uc004dda.1	-	33	4824	c.4580G>A	c.(4579-4581)CGT>CAT	p.R1527H	DMD_uc004dcw.2_Missense_Mutation_p.R183H|DMD_uc004dcx.2_Missense_Mutation_p.R186H|DMD_uc004dcz.2_Missense_Mutation_p.R1404H|DMD_uc004dcy.1_Missense_Mutation_p.R1523H|DMD_uc004ddb.1_Missense_Mutation_p.R1519H|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1527	Spectrin 10.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TACAATCTGACGTCCAGTCTT	0.353													T	32404521	T	T	32404521	3	4	206	1	0	0	0	0	1	0	0	0	4580	536	19	1	6813	1	DMD	23	32404521	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	2143914	32404521	122866039	88	14539											
OTC	5009	broad.mit.edu	37	chrX	38260580	38260580	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctcgagtgtataaacaatcaGatttggacaccctggctaaa	8	9	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:38260580G>A	uc004def.3	+	5	653	c.439G>A	c.(439-441)GAT>AAT	p.D147N		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor	147					arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	TAAACAATCAGATTTGGACAC	0.408													A	38260580	A	A	38260580	3	1	206	1	0	0	0	0	1	0	0	0	11301	942	33	3	457	3	OTC	23	38260580	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	5856059	38260580	117009980	89	14540											
MAGED1	9500	broad.mit.edu	37	chrX	51640084	51640084	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	actggcagaacctgcgccccTcgcctaacctgcgcccttct	8	19	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:51640084T>A	uc004dpm.2	+	4	1428	c.1333T>A	c.(1333-1335)TCG>ACG	p.S445T	MAGED1_uc004dpn.2_Missense_Mutation_p.S501T|MAGED1_uc004dpo.2_Missense_Mutation_p.S445T	NM_001005332	NP_001005332	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1 isoform b	445	Pro-rich.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			ovary(3)	3	Ovarian(276;0.236)					CCTGCGCCCCTCGCCTAACCT	0.602										Multiple Myeloma(10;0.10)			A	51640084	A	A	51640084	3	1	206	1	0	0	0	0	1	0	0	0	9183	1551	54	5	1515	5	MAGED1	23	51640084	Missense_Mutation	SNP	T	TCGA-28-2513-01A-01D-1494-08	13379504	51640084	103630476	90	14541											
CDX4	1046	broad.mit.edu	37	chrX	72667161	72667161	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcatgagccctgggggcgaCggcacagctgggacaggcgg	18	12	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:72667161C>T	uc011mqk.1	+	1	72	c.72C>T	c.(70-72)GAC>GAT	p.D24D		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	24						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					CTGGGGGCGACGGCACAGCTG	0.612													T	72667161	T	T	72667161	2	4	206	1	0	0	0	0	0	0	0	1	3184	535	19	1		1	CDX4	23	72667161	Silent	SNP	C	TCGA-28-2513-01A-01D-1494-08	21027077	72667161	82603399	91	14542											
PCDH19	57526	broad.mit.edu	37	chrX	99662512	99662512	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatcacgtagcccgggggggCgctctcgctgacctccacaa	13	15	2	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:99662512C>T	uc010nmz.2	-	1	2760	c.1084G>A	c.(1084-1086)GCC>ACC	p.A362T	PCDH19_uc004efw.3_Missense_Mutation_p.A362T|PCDH19_uc004efx.3_Missense_Mutation_p.A362T	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	362	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CCCGGGGGGGCGCTCTCGCTG	0.607													T	99662512	T	T	99662512	3	4	206	1	0	0	0	0	1	0	0	0	11514	768	27	1	2386	1	PCDH19	23	99662512	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	26995351	99662512	55608048	92	14543											
DDX26B	203522	broad.mit.edu	37	chrX	134681139	134681139	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaaaaagttcagagtggtGtagttattaattttgaaaaa	8	2	2	2			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:134681139G>A	uc004eyw.3	+	6	1054	c.691G>A	c.(691-693)GTA>ATA	p.V231I		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	231											0	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGAGTGGTGTAGTTATTAA	0.338													A	134681139	A	A	134681139	3	1	206	1	0	0	0	0	1	0	0	0	4353	1377	48	3	713	3	DDX26B	23	134681139	Missense_Mutation	SNP	G	TCGA-28-2513-01A-01D-1494-08	35018627	134681139	20589421	93	14544											
CSAG1	158511	broad.mit.edu	37	chrX	151908921	151908921	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccaacaaccacccatcaacaCcaaagaggcgaggaagggga	10	13	1	1			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:151908921C>A	uc004fge.2	+	4	488	c.160C>A	c.(160-162)CCA>ACA	p.P54T	CSAG1_uc004fgf.2_Missense_Mutation_p.P54T|CSAG1_uc004fgd.2_RNA	NM_153478	NP_705611	Q6PB30	CSAG1_HUMAN	chondrosarcoma associated gene 1 precursor	54										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CCCATCAACACCAAAGAGGCG	0.557													A	151908921	A	A	151908921	3	1	206	1	0	0	0	0	1	0	0	0	3926	507	18	5	166	5	CSAG1	23	151908921	Missense_Mutation	SNP	C	TCGA-28-2513-01A-01D-1494-08	17227782	151908921	3361639	94	14545											
G6PD	2539	broad.mit.edu	37	chrX	153760436	153760436	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggggatgggcttgggcttcTccagctcaatctggtgcagc	15	10	3	0			TCGA-28-2513-01A-01D-1494-08	TCGA-28-2513-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	52dd150e-abd7-4fd2-abe9-09428c5a610c	1a247427-ee89-4549-b07c-21afee78cb17	g.chrX:153760436T>C	uc004fly.1	-	12	1537	c.1424A>G	c.(1423-1425)GAG>GGG	p.E475G	G6PD_uc004flx.1_Missense_Mutation_p.E505G	NM_001042351	NP_001035810	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase isoform b	475					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTTGGGCTTCTCCAGCTCAAT	0.627													C	153760436	C	C	153760436	3	2	206	1	0	0	0	0	1	0	0	0	6146	1551	54	4	131	4	G6PD	23	153760436	Missense_Mutation	SNP	T	TCGA-28-2513-01A-01D-1494-08	1851515	153760436	1510124	95	14546											
PLCH2	9651	broad.mit.edu	37	chr1	2411398	2411398	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaggacagcctggctcgccGccagcgcaccagggaccaat	13	16	0	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr1:2411398G>A	uc001aji.1	+	3	771	c.497G>A	c.(496-498)CGC>CAC	p.R166H	PLCH2_uc010nyz.1_5'Flank|PLCH2_uc009vle.1_5'Flank|PLCH2_uc001ajj.1_5'Flank|PLCH2_uc001ajk.1_5'Flank	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	166					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CTGGCTCGCCGCCAGCGCACC	0.687													A	2411398	A	A	2411398	3	1	207	1	0	0	0	0	1	0	0	0	12038	1087	38	1	507	1	PLCH2	1	2411398	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08		2411398	246839223	1	14547											
PTPN22	26191	broad.mit.edu	37	chr1	114399229	114399229	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctggctcagcccagtagcGctcacactttttctgttgca	8	14	3	0	rs115552198	byFrequency	TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr1:114399229G>A	uc001eds.2	-	6	551	c.421C>T	c.(421-423)CGC>TGC	p.R141C	uc001edv.1_5'Flank|PTPN22_uc009wgq.2_Missense_Mutation_p.R141C|PTPN22_uc010owo.1_Intron|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.R141C|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Missense_Mutation_p.R141C	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	141	Tyrosine-protein phosphatase.				negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCCAGTAGCGCTCACACTTT	0.438													A	114399229	A	A	114399229	3	1	207	1	0	0	0	0	1	0	0	0	12787	1087	38	1	2089	1	PTPN22	1	114399229	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08	111987831	114399229	134851392	2	14548											
DYSF	8291	broad.mit.edu	37	chr2	71801344	71801344	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcacaggcaggcggaggCggagggcgagggctgggagt	23	8	0	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr2:71801344C>T	uc002sie.2	+	30	3567	c.3191C>T	c.(3190-3192)GCG>GTG	p.A1064V	DYSF_uc010feg.2_Missense_Mutation_p.A1095V|DYSF_uc010feh.2_Missense_Mutation_p.A1050V|DYSF_uc002sig.3_Missense_Mutation_p.A1050V|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.A1064V|DYSF_uc010fef.2_Missense_Mutation_p.A1081V|DYSF_uc010fei.2_Missense_Mutation_p.A1081V|DYSF_uc010fek.2_Missense_Mutation_p.A1082V|DYSF_uc010fej.2_Missense_Mutation_p.A1051V|DYSF_uc010fel.2_Missense_Mutation_p.A1051V|DYSF_uc010feo.2_Missense_Mutation_p.A1096V|DYSF_uc010fem.2_Missense_Mutation_p.A1065V|DYSF_uc010fen.2_Missense_Mutation_p.A1082V|DYSF_uc002sif.2_Missense_Mutation_p.A1065V|DYSF_uc010yqy.1_5'Flank	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1064	Cytoplasmic (Potential).|Arg-rich.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CAGGCGGAGGCGGAGGGCGAG	0.662													T	71801344	T	T	71801344	3	4	207	1	0	0	0	0	1	0	0	0	4859	768	27	1	3501	1	DYSF	2	71801344	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08		71801344	171398029	3	14549											
SLC9A4	389015	broad.mit.edu	37	chr2	103095611	103095611	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggcctttggcctgggcgaCgtcaacctgctgcagaacct	12	13	1	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr2:103095611C>T	uc002tbz.3	+	2	1027	c.570C>T	c.(568-570)GAC>GAT	p.D190D		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	190	Extracellular (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GCCTGGGCGACGTCAACCTGC	0.632													T	103095611	T	T	103095611	2	4	207	1	0	0	0	0	0	0	0	1	14716	535	19	1		1	SLC9A4	2	103095611	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08	31294267	103095611	140103762	4	14550											
DPP10	57628	broad.mit.edu	37	chr2	116447456	116447456	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccagaagtagaggactccGtcttgcagtacgcggcctgg	13	12	1	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr2:116447456G>A	uc002tla.1	+	7	992	c.535G>A	c.(535-537)GTC>ATC	p.V179I	DPP10_uc002tlb.1_Missense_Mutation_p.V129I|DPP10_uc002tlc.1_Missense_Mutation_p.V175I|DPP10_uc002tle.2_Missense_Mutation_p.V183I|DPP10_uc002tlf.1_Missense_Mutation_p.V172I	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	179	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AGAGGACTCCGTCTTGCAGTA	0.438													A	116447456	A	A	116447456	3	1	207	1	0	0	0	0	1	0	0	0	4727	1145	40	1	732	1	DPP10	2	116447456	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08	13351845	116447456	126751917	5	14551											
ABCB11	8647	broad.mit.edu	37	chr2	169850255	169850255	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctgctccaatcccaatgagaGggctgacagaaataataacc	8	11	0	3			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr2:169850255G>C	uc002ueo.1	-	8	875	c.749C>G	c.(748-750)CCT>CGT	p.P250R		NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	250	Helical; (Potential).|ABC transmembrane type-1 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CCCAATGAGAGGGCTGACAGA	0.453													C	169850255	C	C	169850255	3	2	207	1	0	0	0	0	1	0	0	0	42	1000	35	5	3300	5	ABCB11	2	169850255	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08	53402799	169850255	73349118	6	14552											
FBLN2	2199	broad.mit.edu	37	chr3	13670777	13670777	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctttcagcgggatgcctttGgccggggctgcatcggtagg	17	10	1	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr3:13670777G>A	uc011avb.1	+	12	2811	c.2686G>A	c.(2686-2688)GGC>AGC	p.G896S	FBLN2_uc011auz.1_Missense_Mutation_p.G922S|FBLN2_uc011ava.1_Missense_Mutation_p.G943S|FBLN2_uc011avc.1_Missense_Mutation_p.G943S	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	896	EGF-like 6; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GGATGCCTTTGGCCGGGGCTG	0.662													A	13670777	A	A	13670777	3	1	207	1	0	0	0	0	1	0	0	0	5699	1348	47	3	1563	3	FBLN2	3	13670777	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08		13670777	184351653	7	14553											
TRAT1	50852	broad.mit.edu	37	chr3	108549621	108549621	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccactatgtggaaaagcaaCgacaaggtaagacattttga	9	8	0	2	rs148894492		TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr3:108549621C>T	uc003dxi.1	+	2	256	c.112C>T	c.(112-114)CGA>TGA	p.R38*	TRAT1_uc010hpx.1_Intron	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	38	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						GGAAAAGCAACGACAAGGTAA	0.418													T	108549621	T	T	108549621	4	4	207	1	0	0	0	0	0	1	0	0	16463	528	19	1	118	1	TRAT1	3	108549621	Nonsense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	94878844	108549621	89472809	8	14554											
IFT80	57560	broad.mit.edu	37	chr3	160083930	160083930	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggccccacgctactgaataCactggtgttcctgtaagatg	11	11	0	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr3:160083930C>T	uc011boy.1	-	6	883	c.450G>A	c.(448-450)GTG>GTA	p.V150V	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Silent_p.V13V|IFT80_uc003fdd.1_Intron|IFT80_uc003fde.1_Silent_p.V13V	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	150	WD 3.					cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CTACTGAATACACTGGTGTTC	0.353													T	160083930	T	T	160083930	2	4	207	1	0	0	0	0	0	0	0	1	7564	465	17	3		3	IFT80	3	160083930	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08	51534309	160083930	37938500	9	14555											
RBM47	54502	broad.mit.edu	37	chr4	40440481	40440481	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgtccacgctgcagcacaCgccgagcaggcggcccgggc	15	16	0	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr4:40440481C>T	uc003gvc.2	-	4	1140	c.430G>A	c.(430-432)GTG>ATG	p.V144M	RBM47_uc003gvd.2_Missense_Mutation_p.V144M|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.V106M|RBM47_uc003gvg.1_Missense_Mutation_p.V144M	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	144	RRM 1.					nucleus	nucleotide binding|RNA binding			breast(3)	3						CTGCAGCACACGCCGAGCAGG	0.637													T	40440481	T	T	40440481	3	4	207	1	0	0	0	0	1	0	0	0	13141	536	19	1	1367	1	RBM47	4	40440481	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08		40440481	150713795	10	14556											
LRRC66	339977	broad.mit.edu	37	chr4	52869513	52869513	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accctatttgcaatatcccaTtgaatgacagatccaaactc	4	12	0	3			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr4:52869513T>C	uc003gzi.2	-	2	555	c.542A>G	c.(541-543)AAT>AGT	p.N181S		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	181	LRR 4.					integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CAATATCCCATTGAATGACAG	0.313													C	52869513	C	C	52869513	3	2	207	1	0	0	0	0	1	0	0	0	9018	1493	52	4	2112	4	LRRC66	4	52869513	Missense_Mutation	SNP	T	TCGA-28-2514-01A-02D-1494-08	12429032	52869513	138284763	11	14557											
SULT1B1	27284	broad.mit.edu	37	chr4	70596318	70596318	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	catcacttcaaatgaggtgtGatggatgatcctatccaaga	9	8	2	4			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr4:70596318G>A	uc003hen.2	-	7	977	c.679C>T	c.(679-681)CAC>TAC	p.H227Y		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	227	PAPS (By similarity).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						AATGAGGTGTGATGGATGATC	0.378													A	70596318	A	A	70596318	3	1	207	1	0	0	0	0	1	0	0	0	15373	1290	45	3	219	3	SULT1B1	4	70596318	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08	17726805	70596318	120557958	12	14558											
C4orf40	401137	broad.mit.edu	37	chr4	71021774	71021774	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttttctttattttagagaCggttccccttcattggtgag	8	7	2	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr4:71021774C>T	uc003hfa.3	+	3	128	c.55C>T	c.(55-57)CGG>TGG	p.R19W	C4orf40_uc003hfb.3_Missense_Mutation_p.R19W	NM_214711	NP_999876	Q6MZM9	CD040_HUMAN	hypothetical protein LOC401137 precursor	19						extracellular region					0						ATTTTAGAGACGGTTCCCCTT	0.259													T	71021774	T	T	71021774	3	4	207	1	0	0	0	0	1	0	0	0	2269	527	19	1	61	1	C4orf40	4	71021774	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	425456	71021774	120132502	13	14559											
AFM	173	broad.mit.edu	37	chr4	74365901	74365901	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatttacctttcacgcagacAtgtgtcaatctcagaatgag	7	9	3	3	rs149561663		TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr4:74365901A>C	uc003hhb.2	+	12	1634	c.1603A>C	c.(1603-1605)ATG>CTG	p.M535L		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	535	Albumin 3.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCACGCAGACATGTGTCAATC	0.393													C	74365901	C	C	74365901	3	2	207	1	0	0	0	0	1	0	0	0	361	217	8	5	1649	5	AFM	4	74365901	Missense_Mutation	SNP	A	TCGA-28-2514-01A-02D-1494-08	3344127	74365901	116788375	14	14560											
AGXT2L1	64850	broad.mit.edu	37	chr4	109667553	109667553	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttaaagatccatggacccAcctgttagaatcctatcaag	6	11	2	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr4:109667553A>G	uc003hzc.2	-	11	1484	c.1303_splice	c.e11+1	p.V435_splice	AGXT2L1_uc010imc.2_Splice_Site_p.V429_splice|AGXT2L1_uc011cfm.1_Splice_Site_p.V395_splice|AGXT2L1_uc011cfn.1_Splice_Site_p.V362_splice|AGXT2L1_uc011cfo.1_Splice_Site_p.V377_splice	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1						cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		CCATGGACCCACCTGTTAGAA	0.413													G	109667553	G	G	109667553	5	3	207	1	0	0	0	0	0	0	1	0	406	173	6	4	206	4	AGXT2L1	4	109667553	Splice_Site	SNP	A	TCGA-28-2514-01A-02D-1494-08	35301652	109667553	81486723	15	14561											
SYNPO2	171024	broad.mit.edu	37	chr4	119948017	119948017	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagaaacaggcccgagctacCaaagggctccccaaatgcct	9	14	0	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr4:119948017C>T	uc003icm.3	+	3	689	c.493C>T	c.(493-495)CAA>TAA	p.Q165*	SYNPO2_uc010ina.2_Nonsense_Mutation_p.Q165*|SYNPO2_uc010inb.2_Nonsense_Mutation_p.Q165*|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Nonsense_Mutation_p.Q93*	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	165						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						CCCGAGCTACCAAAGGGCTCC	0.557													T	119948017	T	T	119948017	4	4	207	1	0	0	0	0	0	1	0	0	15454	595	21	3	503	3	SYNPO2	4	119948017	Nonsense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	10280464	119948017	71206259	16	14562											
CAMK4	814	broad.mit.edu	37	chr5	110818505	110818505	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagaaaattaattgttttggAtccaaagaaacggctgacta	8	6	0	3			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr5:110818505A>C	uc011cvj.1	+	11	950	c.851A>C	c.(850-852)GAT>GCT	p.D284A	CAMK4_uc003kpf.2_Missense_Mutation_p.D284A|CAMK4_uc010jbv.2_Missense_Mutation_p.D87A|CAMK4_uc003kpg.2_5'UTR	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	284	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		ATTGTTTTGGATCCAAAGAAA	0.423													C	110818505	C	C	110818505	3	2	207	1	0	0	0	0	1	0	0	0	2605	333	12	5	889	5	CAMK4	5	110818505	Missense_Mutation	SNP	A	TCGA-28-2514-01A-02D-1494-08		110818505	70096755	17	14563											
PCDHB7	56129	broad.mit.edu	37	chr5	140553289	140553289	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	actgaaagaattctcaaaacGtttcaaatcaatccaacatc	3	10	3	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr5:140553289G>T	uc003lit.2	+	1	1047	c.873G>T	c.(871-873)ACG>ACT	p.T291T		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	291	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCTCAAAACGTTTCAAATCA	0.418													T	140553289	T	T	140553289	2	4	207	1	0	0	0	0	0	0	0	1	11547	1132	40	5		5	PCDHB7	5	140553289	Silent	SNP	G	TCGA-28-2514-01A-02D-1494-08	29734784	140553289	40361971	18	14564											
KIAA1244	57221	broad.mit.edu	37	chr6	138559683	138559683	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cataagcagctgtcaccagcGtagcataaacactgctgtgc	9	12	1	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr6:138559683G>A	uc003qhu.2	+	6	458	c.458G>A	c.(457-459)CGT>CAT	p.R153H		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	153					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TGTCACCAGCGTAGCATAAAC	0.453													A	138559683	A	A	138559683	3	1	207	1	0	0	0	0	1	0	0	0	8217	1145	40	1	480	1	KIAA1244	6	138559683	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08		138559683	32555384	19	14565											
RNASET2	8635	broad.mit.edu	37	chr6	167360227	167360227	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catccttcacttttatcgggCctggaaattcaaatttaaaa	5	9	2	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr6:167360227C>T	uc003qve.2	-	4	611	c.204G>A	c.(202-204)TGG>TGA	p.W68*	RNASET2_uc003qvh.2_Intron|RNASET2_uc003qvf.2_5'UTR|RNASET2_uc003qvg.2_Silent_p.K5K|RNASET2_uc003qvi.1_Intron	NM_003730	NP_003721	O00584	RNT2_HUMAN	ribonuclease T2 precursor	68					RNA catabolic process	extracellular region	ribonuclease T2 activity|RNA binding				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;1.53e-19)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00665)		TTTTATCGGGCCTGGAAATTC	0.348													T	167360227	T	T	167360227	4	4	207	1	0	0	0	0	0	1	0	0	13418	753	26	3	590	3	RNASET2	6	167360227	Nonsense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	28800544	167360227	3754840	20	14566											
ABCA13	154664	broad.mit.edu	37	chr7	48443394	48443394	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcatgggcatgtcgaggacCgtggttctggatgagcccac	14	10	2	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr7:48443394C>T	uc003toq.2	+	39	12013	c.11988C>T	c.(11986-11988)ACC>ACT	p.T3996T	ABCA13_uc010kys.1_Silent_p.T1070T|ABCA13_uc003tos.1_Silent_p.T822T|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3996	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TGTCGAGGACCGTGGTTCTGG	0.572													T	48443394	T	T	48443394	2	4	207	1	0	0	0	0	0	0	0	1	31	639	23	2		2	ABCA13	7	48443394	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08		48443394	110695269	21	14567											
EIF4H	7458	broad.mit.edu	37	chr7	73601967	73601967	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cggcagtgctggtggccatgGttcccgtagccagaaggagt	16	10	0	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr7:73601967G>T	uc003uad.1	+	2	94	c.86G>T	c.(85-87)GGT>GTT	p.G29V	RFC2_uc011kfa.1_Intron|EIF4H_uc011kfg.1_Missense_Mutation_p.G29V|EIF4H_uc010lbm.2_Missense_Mutation_p.G29V|EIF4H_uc003uae.1_Missense_Mutation_p.G29V|EIF4H_uc003uaf.1_Intron	NM_022170	NP_071496	Q15056	IF4H_HUMAN	eukaryotic translation initiation factor 4H	29					interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0						GGTGGCCATGGTTCCCGTAGC	0.527													T	73601967	T	T	73601967	3	4	207	1	0	0	0	0	1	0	0	0	5039	1261	44	5	92	5	EIF4H	7	73601967	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08	25158573	73601967	85536696	22	14568											
PILRA	29992	broad.mit.edu	37	chr7	99996939	99996939	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttccaaaacacagaggagCcatatgagaatatcaggaat	8	9	1	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr7:99996939C>T	uc003uuo.1	+	5	945	c.733C>T	c.(733-735)CCA>TCA	p.P245S	PILRA_uc011kjo.1_Missense_Mutation_p.P172S|PILRA_uc003uup.1_Missense_Mutation_p.P172S|PILRA_uc003uuq.1_Silent_p.S160S	NM_013439	NP_038467	Q9UKJ1	PILRA_HUMAN	paired immunoglobulin-like type 2 receptor alpha	245	Cytoplasmic (Potential).				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CACAGAGGAGCCATATGAGAA	0.483													T	99996939	T	T	99996939	3	4	207	1	0	0	0	0	1	0	0	0	11925	739	26	3	751	3	PILRA	7	99996939	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	26394972	99996939	59141724	23	14569											
GRM8	2918	broad.mit.edu	37	chr7	126249517	126249517	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataacgtccaggagcatctcCgttttcattaaaagtgacag	8	9	2	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr7:126249517C>T	uc003vlr.2	-	7	1704	c.1393G>A	c.(1393-1395)GGA>AGA	p.G465R	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.G465R|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	465	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GGAGCATCTCCGTTTTCATTA	0.378										HNSCC(24;0.065)			T	126249517	T	T	126249517	3	4	207	1	0	0	0	0	1	0	0	0	6803	661	23	2	1399	2	GRM8	7	126249517	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	26252578	126249517	32889146	24	14570											
IDO1	3620	broad.mit.edu	37	chr8	39782809	39782809	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tctgggaagacccaaaggagTttgcagggggcagtgcaggc	17	8	1	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr8:39782809T>A	uc003xnm.2	+	9	889	c.775T>A	c.(775-777)TTT>ATT	p.F259I	IDO1_uc003xnn.2_RNA	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	259					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	CCCAAAGGAGTTTGCAGGGGG	0.507													A	39782809	A	A	39782809	3	1	207	1	0	0	0	0	1	0	0	0	7501	1725	60	5	809	5	IDO1	8	39782809	Missense_Mutation	SNP	T	TCGA-28-2514-01A-02D-1494-08		39782809	106581213	25	14571											
RAD21	5885	broad.mit.edu	37	chr8	117875483	117875483	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taagagatgtcctgatgtccGtaatgccattttcacctatg	8	9	1	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr8:117875483G>A	uc003yod.2	-	3	448	c.160C>T	c.(160-162)CGG>TGG	p.R54W		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	54					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					CCTGATGTCCGTAATGCCATT	0.348													A	117875483	A	A	117875483	3	1	207	1	0	0	0	0	1	0	0	0	12981	1144	40	1	1783	1	RAD21	8	117875483	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08	78092674	117875483	28488539	26	14572											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112686091	112686091	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcaaatcatcctagagaaaCtgaaggaaacagaaaaatcc	7	8	1	3			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr9:112686091C>T	uc004bei.2	+	4	526	c.334C>T	c.(334-336)CTG>TTG	p.L112L	PALM2_uc004bef.2_Silent_p.L114L|PALM2_uc004beg.2_Silent_p.L114L|PALM2_uc004beh.3_Silent_p.L112L|PALM2-AKAP2_uc004bek.3_Silent_p.L112L|PALM2-AKAP2_uc004bej.3_Silent_p.L112L|PALM2-AKAP2_uc004bel.1_5'UTR	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:Variant_position_missing_in_Q9Y2D5_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CCTAGAGAAACTGAAGGAAAC	0.403													T	112686091	T	T	112686091	2	4	207	1	0	0	0	0	0	0	0	1	11410	564	20	3		3	PALM2-AKAP2	9	112686091	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08		112686091	28527340	27	14573											
SUV39H2	79723	broad.mit.edu	37	chr10	14938880	14938880	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttgtaaaatggaaaggatgGccagattctacaaatacttg	9	6	1	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr10:14938880G>T	uc001inh.2	+	2	89	c.33G>T	c.(31-33)TGG>TGT	p.W11C	SUV39H2_uc001ing.2_Missense_Mutation_p.W71C|SUV39H2_uc001ini.2_Missense_Mutation_p.W11C|SUV39H2_uc001inj.2_Missense_Mutation_p.W11C	NM_024670	NP_078946	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2	71	Chromo.				cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding			breast(2)|ovary(1)	3						GGAAAGGATGGCCAGATTCTA	0.323													T	14938880	T	T	14938880	3	4	207	1	0	0	0	0	1	0	0	0	15410	1212	42	5	35	5	SUV39H2	10	14938880	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08		14938880	120595867	28	14574											
MKI67	4288	broad.mit.edu	37	chr10	129901939	129901947	+	In_Frame_Del	DEL	CTCTTTGTG	-	-													gcacacgtgtcctgagatgcCtctttgtgcttgctgtggtg					rs1050767	byFrequency	TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr10:129901939_129901947delCTCTTTGTG	uc001lke.2	-	13	8352_8360	c.8157_8165delCACAAAGAG	c.(8155-8166)AGCACAAAGAGG>AGG	p.STK2719del	MKI67_uc001lkf.2_In_Frame_Del_p.STK2359del|MKI67_uc009yav.1_In_Frame_Del_p.STK2294del|MKI67_uc009yaw.1_In_Frame_Del_p.STK1869del	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2719_2721	16 X 122 AA approximate repeats.|15.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CCTGAGATGCCTCTTTGTGCTTGCTGTGG	0.483													-	129901947	-	-	129901939	7	5	207	1	0	1	0	1	0	0	0	0	9598	681	24	0	1617	0	MKI67	10	129901939	In_Frame_Del	DEL	CTCTTTGTG	TCGA-28-2514-01A-02D-1494-08	114963059	129901939	5632808	29	14575											
SYTL2	54843	broad.mit.edu	37	chr11	85445443	85445443	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aatgctccttctcagaaattCtctcatggatggttaggcca	8	10	3	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr11:85445443C>T	uc010rth.1	-	6	1202	c.926G>A	c.(925-927)AGA>AAA	p.R309K	SYTL2_uc010rtg.1_Missense_Mutation_p.R310K|SYTL2_uc010rti.1_Missense_Mutation_p.R309K|SYTL2_uc010rtj.1_Missense_Mutation_p.R261K|SYTL2_uc001pbf.3_Missense_Mutation_p.R309K|SYTL2_uc010rtf.1_Missense_Mutation_p.R167K	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	309					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CTCAGAAATTCTCTCATGGAT	0.438													T	85445443	T	T	85445443	3	4	207	1	0	0	0	0	1	0	0	0	15480	913	32	3	4411	3	SYTL2	11	85445443	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08		85445443	49561073	30	14576											
PDZD3	79849	broad.mit.edu	37	chr11	119058000	119058000	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggtacgccgcatccgggccAgcagccctcgggtgttgctg	15	14	0	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr11:119058000A>T	uc001pwb.2	+	3	1074	c.550A>T	c.(550-552)AGC>TGC	p.S184C	PDZD3_uc001pvy.2_Missense_Mutation_p.S118C|PDZD3_uc001pvz.2_Missense_Mutation_p.S118C|PDZD3_uc010rzd.1_Missense_Mutation_p.S105C|PDZD3_uc001pwa.2_5'UTR			Q86UT5	NHRF4_HUMAN	RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF4;          Short=NHERF-4; AltName: Full=PDZ domain-containing protein 3; AltName: Full=PDZ domain-containing protein 2; AltName: Full=Intestinal and kidney-enriched PDZ protein; AltName: Full=Sodium-hydrogen exchanger regulatory factor 4;	184	PDZ 1.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)	1	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		CATCCGGGCCAGCAGCCCTCG	0.632													T	119058000	T	T	119058000	3	4	207	1	0	0	0	0	1	0	0	0	11702	188	7	5	370	5	PDZD3	11	119058000	Missense_Mutation	SNP	A	TCGA-28-2514-01A-02D-1494-08	33612557	119058000	15948516	31	14577											
PRIM1	5557	broad.mit.edu	37	chr12	57140741	57140741	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctcacatcgtcatagtctgTcatgtcaatgtcaaatacca	5	12	6	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr12:57140741T>C	uc001smd.2	-	3	401	c.337A>G	c.(337-339)ACA>GCA	p.T113A	PRIM1_uc001sme.1_RNA|PRIM1_uc009zoz.1_Intron|PRIM1_uc001smf.2_Missense_Mutation_p.T113A	NM_000946	NP_000937	P49642	PRI1_HUMAN	DNA primase polypeptide 1	113					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	DNA primase activity|metal ion binding				0						TCATAGTCTGTCATGTCAATG	0.428													C	57140741	C	C	57140741	3	2	207	1	0	0	0	0	1	0	0	0	12490	1667	58	4	969	4	PRIM1	12	57140741	Missense_Mutation	SNP	T	TCGA-28-2514-01A-02D-1494-08		57140741	76711154	32	14578											
IL26	55801	broad.mit.edu	37	chr12	68619487	68619487	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgtgcttggcaatggcaagaGacagagtgactaacagcaac	12	8	0	3			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr12:68619487G>C	uc001stx.1	-	1	85	c.50C>G	c.(49-51)TCT>TGT	p.S17C		NM_018402	NP_060872	Q9NPH9	IL26_HUMAN	interleukin 26 precursor	17					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		AATGGCAAGAGACAGAGTGAC	0.478													C	68619487	C	C	68619487	3	2	207	1	0	0	0	0	1	0	0	0	7679	942	33	5	485	5	IL26	12	68619487	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08	11478746	68619487	65232408	33	14579											
MIPEP	4285	broad.mit.edu	37	chr13	24448985	24448985	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaacagcagaaagatgtacCttttctttgtctagatggat	8	6	2	3			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr13:24448985C>T	uc001uox.3	-	5	703	c.603G>A	c.(601-603)AAG>AAA	p.K201K		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	201					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		AAAGATGTACCTTTTCTTTGT	0.333													T	24448985	T	T	24448985	2	4	207	1	0	0	0	0	0	0	0	1	9592	695	24	3		3	MIPEP	13	24448985	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08		24448985	90720893	34	14580											
ERCC5	2073	broad.mit.edu	37	chr13	103520596	103520596	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gggcatggcctggaacctctCctaaaattctcgtaaggtct	10	11	3	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr13:103520596C>T	uc001vpw.2	+	12	3110	c.2667C>T	c.(2665-2667)CTC>CTT	p.L889L	ERCC5_uc001vpu.1_Silent_p.L1343L|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Silent_p.L721L	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	889					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TGGAACCTCTCCTAAAATTCT	0.373			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				T	103520596	T	T	103520596	2	4	207	1	0	0	0	0	0	0	0	1	5216	842	30	3		3	ERCC5	13	103520596	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08	79071611	103520596	11649282	35	14581											
ARHGEF7	8874	broad.mit.edu	37	chr13	111896312	111896315	+	Splice_Site	DEL	AAGT	-	-													ggccattgcagaccagtgagAagtaagttagatgataaatt							TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr13:111896312_111896315delAAGT	uc001vrs.2	+	8	1167	c.917_splice	c.e8+1	p.K306_splice	ARHGEF7_uc001vrr.2_Splice_Site_p.K285_splice|ARHGEF7_uc001vrt.2_Splice_Site_p.K256_splice|ARHGEF7_uc010tjn.1_Intron|ARHGEF7_uc001vru.1_Splice_Site_p.K128_splice|ARHGEF7_uc001vrv.3_Splice_Site_p.K128_splice|ARHGEF7_uc001vrw.3_Splice_Site_p.K128_splice|ARHGEF7_uc001vrx.3_Splice_Site_p.K128_splice|ARHGEF7_uc010tjo.1_Splice_Site_p.K203_splice|ARHGEF7_uc010tjp.1_Splice_Site_p.K50_splice|ARHGEF7_uc010agn.1_Splice_Site_p.K50_splice	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c						apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			GACCAGTGAGAAGTAAGTTAGATG	0.324													-	111896315	-	-	111896312	8	5	207	1	0	1	0	1	0	0	1	0	911	260	9	0	946	0	ARHGEF7	13	111896312	Splice_Site	DEL	AAGT	TCGA-28-2514-01A-02D-1494-08	8375716	111896312	3273566	36	14582											
DLK1	8788	broad.mit.edu	37	chr14	101200827	101200827	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctgtgtcaagaagcgcgCgctgagcccccagcaggtca	12	15	2	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr14:101200827C>T	uc001yhs.3	+	5	899	c.746C>T	c.(745-747)GCG>GTG	p.A249V	DLK1_uc001yhu.3_Intron	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	249	Extracellular (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				AAGAAGCGCGCGCTGAGCCCC	0.682													T	101200827	T	T	101200827	3	4	207	1	0	0	0	0	1	0	0	0	4564	768	27	1	764	1	DLK1	14	101200827	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08		101200827	6148713	37	14583											
SIN3A	25942	broad.mit.edu	37	chr15	75693090	75693090	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctctttacagagaggagtcCgtcctgtacacttgggctgc	11	12	1	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr15:75693090C>T	uc002bai.2	-	11	1977	c.1718G>A	c.(1717-1719)CGG>CAG	p.R573Q	SIN3A_uc002baj.2_Missense_Mutation_p.R573Q|SIN3A_uc010uml.1_Missense_Mutation_p.R573Q	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	573	Interactions with SUDS3 and SAP130.|Interaction with NCOR1 (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						GAGAGGAGTCCGTCCTGTACA	0.493													T	75693090	T	T	75693090	3	4	207	1	0	0	0	0	1	0	0	0	14325	652	23	2	2147	2	SIN3A	15	75693090	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08		75693090	26838302	38	14584											
PKD1	5310	broad.mit.edu	37	chr16	2156265	2156265	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcgccgcagcagcagggcGtacaccagcggggcgccagc	16	16	0	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr16:2156265G>A	uc002cos.1	-	19	7739	c.7530C>T	c.(7528-7530)TAC>TAT	p.Y2510Y	PKD1_uc002cot.1_Silent_p.Y2510Y|PKD1_uc010bse.1_5'Flank	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2510	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GCAGCAGGGCGTACACCAGCG	0.687													A	2156265	A	A	2156265	2	1	207	1	0	0	0	0	0	0	0	1	11963	1140	40	1		1	PKD1	16	2156265	Silent	SNP	G	TCGA-28-2514-01A-02D-1494-08		2156265	88198488	39	14585											
CREBBP	1387	broad.mit.edu	37	chr16	3779062	3779062	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacattcaggctcacgggggCcatctggctccccggggtcc	13	16	3	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr16:3779062C>T	uc002cvv.2	-	31	6190	c.5986G>A	c.(5986-5988)GCC>ACC	p.A1996T	CREBBP_uc002cvw.2_Missense_Mutation_p.A1958T	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1996					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CTCACGGGGGCCATCTGGCTC	0.697			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				T	3779062	T	T	3779062	3	4	207	1	0	0	0	0	1	0	0	0	3861	739	26	3	1346	3	CREBBP	16	3779062	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	1622797	3779062	86575691	40	14586											
ANKS3	124401	broad.mit.edu	37	chr16	4755095	4755095	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggaaacgcgggccactcaCcatagcgaggccgtggggct	16	13	1	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr16:4755095C>T	uc002cxj.1	-	8	1163	c.868_splice	c.e8+1	p.E290_splice	ANKS3_uc002cxi.1_Splice_Site_p.E217_splice|ANKS3_uc002cxk.2_Splice_Site_p.E161_splice|ANKS3_uc002cxl.2_Splice_Site_p.E117_splice|ANKS3_uc010uxs.1_Splice_Site_p.E217_splice|ANKS3_uc002cxm.2_Splice_Site_p.E84_splice	NM_133450	NP_597707	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain												0						GGGCCACTCACCATAGCGAGG	0.597													T	4755095	T	T	4755095	5	4	207	1	0	0	0	0	0	0	1	0	690	521	18	3	1141	3	ANKS3	16	4755095	Splice_Site	SNP	C	TCGA-28-2514-01A-02D-1494-08	976033	4755095	85599658	41	14587											
CNGB1	1258	broad.mit.edu	37	chr16	57918280	57918280	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgtccggggcgcgggtgggtCggtggcggcctcctttgggt	21	11	0	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr16:57918280C>T	uc002emt.2	-	33	3609	c.3544G>A	c.(3544-3546)GAC>AAC	p.D1182N	CNGB1_uc010cdh.2_Missense_Mutation_p.D1176N	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	1182	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCGGGTGGGTCGGTGGCGGCC	0.721													T	57918280	T	T	57918280	3	4	207	1	0	0	0	0	1	0	0	0	3600	884	31	2	215	2	CNGB1	16	57918280	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	53163185	57918280	32436473	42	14588											
KRT39	390792	broad.mit.edu	37	chr17	39116542	39116542	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attttacatacttgccatccGagctctccagaaggctgcgg	9	12	1	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr17:39116542G>A	uc002hvo.1	-	6	1244	c.1208C>T	c.(1207-1209)TCG>TTG	p.S403L	KRT39_uc010wfm.1_Missense_Mutation_p.S136L	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	403	Coil 2.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				CTTGCCATCCGAGCTCTCCAG	0.468													A	39116542	A	A	39116542	3	1	207	1	0	0	0	0	1	0	0	0	8476	1059	37	2	275	2	KRT39	17	39116542	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08		39116542	42078668	43	14589											
ONECUT2	9480	broad.mit.edu	37	chr18	55103358	55103358	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catgagcatgtcctgcgactCgtctccgcctggcatgggca	12	14	1	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr18:55103358C>T	uc002lgo.2	+	1	442	c.410C>T	c.(409-411)TCG>TTG	p.S137L		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	137					organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		TCCTGCGACTCGTCTCCGCCT	0.617													T	55103358	T	T	55103358	3	4	207	1	0	0	0	0	1	0	0	0	10869	893	31	2	412	2	ONECUT2	18	55103358	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08		55103358	22973890	44	14590											
APC2	10297	broad.mit.edu	37	chr19	1466495	1466496	+	Frame_Shift_Ins	INS	-	T	T													cggcgcaagaggggccactcINStcgctgtcccgatgcagctc							TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:1466495_1466496insT	uc002lsr.1	+	15	3403_3404	c.3195_3196insT	c.(3193-3198)CTCTCGfs	p.L1065fs	APC2_uc002lss.1_Frame_Shift_Ins_p.L647fs|APC2_uc002lst.1_Frame_Shift_Ins_p.L1065fs|APC2_uc002lsu.1_Frame_Shift_Ins_p.L1064fs|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1065_1066	Interaction with CTNNB1.|1.|5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGGCCACTCTCGCTGTCCCG	0.683													T	1466496	T	T	1466495	7	5	207	1	0	1	1	0	0	0	0	0	764	900	32	0	3249	0	APC2	19	1466495	Frame_Shift_Ins	INS	-	TCGA-28-2514-01A-02D-1494-08		1466495	57662488	45	14591											
CELF5	60680	broad.mit.edu	37	chr19	3293345	3293345	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctttgataacccggccagCgcccaggcagccatccaggc	11	16	0	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:3293345C>T	uc002lxm.2	+	12	1396	c.1359C>T	c.(1357-1359)AGC>AGT	p.S453S	CELF5_uc002lxl.1_3'UTR|CELF5_uc010dtj.1_3'UTR|CELF5_uc010xhg.1_3'UTR|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	453	RRM 3.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						ACCCGGCCAGCGCCCAGGCAG	0.622													T	3293345	T	T	3293345	2	4	207	1	0	0	0	0	0	0	0	1	3219	767	27	1		1	CELF5	19	3293345	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08	1826850	3293345	55835638	46	14592											
TNFSF14	8740	broad.mit.edu	37	chr19	6664993	6664993	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcacgcagtcgaaccaggcGttcatccagcacacggacga	10	14	2	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:6664993G>A	uc002mfk.1	-	5	1049	c.667C>T	c.(667-669)CGC>TGC	p.R223C	TNFSF14_uc002mfj.1_Missense_Mutation_p.R187C	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	223	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						CGAACCAGGCGTTCATCCAGC	0.612													A	6664993	A	A	6664993	3	1	207	1	0	0	0	0	1	0	0	0	16304	1145	40	1	59	1	TNFSF14	19	6664993	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08	3371648	6664993	52463990	47	14593											
TNFSF14	8740	broad.mit.edu	37	chr19	6665273	6665273	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaccacaagggccccatcGtggtagctgaggcccctcag	13	14	1	2	rs147375196		TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:6665273G>A	uc002mfk.1	-	5	769	c.387C>T	c.(385-387)CAC>CAT	p.H129H	TNFSF14_uc002mfj.1_Silent_p.H93H	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	129	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						GGGCCCCATCGTGGTAGCTGA	0.647													A	6665273	A	A	6665273	2	1	207	1	0	0	0	0	0	0	0	1	16304	1136	40	1		1	TNFSF14	19	6665273	Silent	SNP	G	TCGA-28-2514-01A-02D-1494-08	280	6665273	52463710	48	14594											
LRRC8E	80131	broad.mit.edu	37	chr19	7964176	7964176	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgtacaccatgtacatcCgacagacggtgctgaaagtg	10	11	0	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:7964176C>T	uc002mir.2	+	3	870	c.769C>T	c.(769-771)CGA>TGA	p.R257*		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	257						integral to membrane				lung(1)|pancreas(1)	2						CATGTACATCCGACAGACGGT	0.532													T	7964176	T	T	7964176	4	4	207	1	0	0	0	0	0	1	0	0	9025	644	23	2	775	2	LRRC8E	19	7964176	Nonsense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	1298903	7964176	51164807	49	14595											
LDLR	3949	broad.mit.edu	37	chr19	11221368	11221368	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacaacggcggctgttcccaCgtctgcaatgaccttaagat	9	12	1	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:11221368C>T	uc002mqk.3	+	7	1149	c.981C>T	c.(979-981)CAC>CAT	p.H327H	LDLR_uc010xlk.1_Silent_p.H327H|LDLR_uc010xll.1_Silent_p.H286H|LDLR_uc010xlm.1_Silent_p.H180H|LDLR_uc010xln.1_Silent_p.H200H|LDLR_uc010xlo.1_Silent_p.H159H	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	327	Extracellular (Potential).|EGF-like 1.		H -> Y (in FH).		cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GCTGTTCCCACGTCTGCAATG	0.627													T	11221368	T	T	11221368	2	4	207	1	0	0	0	0	0	0	0	1	8704	535	19	1		1	LDLR	19	11221368	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08	3257192	11221368	47907615	50	14596											
FFAR2	2867	broad.mit.edu	37	chr19	35941517	35941517	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggctcctccctgttgggaCgcagaggcaaagacacagca	13	12	0	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:35941517C>T	uc002nzg.2	+	2	981	c.901C>T	c.(901-903)CGC>TGC	p.R301C	FFAR2_uc010eea.2_Missense_Mutation_p.R301C	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	301	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCTGTTGGGACGCAGAGGCAA	0.567													T	35941517	T	T	35941517	3	4	207	1	0	0	0	0	1	0	0	0	5828	536	19	1	903	1	FFAR2	19	35941517	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	24720149	35941517	23187466	51	14597											
PSG8	440533	broad.mit.edu	37	chr19	43359720	43359720	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctcctcacctgtgagcaggaCccccttccatttgatgtgct	8	15	1	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:43359720C>G	uc002oul.3	-	1	151	c.52G>C	c.(52-54)GTC>CTC	p.V18L	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG8_uc002oum.3_Missense_Mutation_p.V18L|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.V18L|PSG10_uc010eip.2_RNA|PSG1_uc002our.1_Intron|PSG1_uc010eio.1_Intron|PSG1_uc002oux.1_Intron|PSG1_uc002ouy.1_Intron	NM_001130168	NP_001123640	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	18						extracellular region					0		Prostate(69;0.00899)				GTGAGCAGGACCCCCTTCCAT	0.567													G	43359720	G	G	43359720	3	3	207	1	0	0	0	0	1	0	0	0	12661	522	18	5		5	PSG8	19	43359720	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	7418203	43359720	15769263	52	14598											
KIR2DS4	3809	broad.mit.edu	37	chr19	55351111	55351111	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctttccgtgacgctccctaCgagtggtcaaactcgagtga	10	12	2	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:55351111C>T	uc002qhm.1	+	5	667	c.621C>T	c.(619-621)TAC>TAT	p.Y207Y	KIR2DS4_uc010yfj.1_Missense_Mutation_p.T193M|KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Missense_Mutation_p.T200M|KIR2DS4_uc002qhn.1_Intron	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	207	Extracellular (Potential).					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		ACGCTCCCTACGAGTGGTCAA	0.562													T	55351111	T	T	55351111	2	4	207	1	0	0	0	0	0	0	0	1	8319	536	19	1		1	KIR2DS4	19	55351111	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08	11991391	55351111	3777872	53	14599											
NLRP2	55655	broad.mit.edu	37	chr19	55495082	55495082	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcactgcgtctgaatcagaCgccgaggttgagaggtgaga	15	8	3	4			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:55495082C>T	uc002qij.2	+	6	2102	c.2016C>T	c.(2014-2016)GAC>GAT	p.D672D	NLRP2_uc010yfp.1_Silent_p.D649D|NLRP2_uc010esn.2_Silent_p.D648D|NLRP2_uc010eso.2_Silent_p.D669D|NLRP2_uc010esp.2_Silent_p.D650D	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	672					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTGAATCAGACGCCGAGGTTG	0.507													T	55495082	T	T	55495082	2	4	207	1	0	0	0	0	0	0	0	1	10477	535	19	1		1	NLRP2	19	55495082	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08	143971	55495082	3633901	54	14600											
PTPRH	5794	broad.mit.edu	37	chr19	55693402	55693402	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctcagtctgcaccatcaaCggccgactctctctcatctt	5	17	6	0			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr19:55693402C>T	uc002qjq.2	-	19	3253	c.3180G>A	c.(3178-3180)CCG>CCA	p.P1060P	PTPRH_uc010esv.2_Silent_p.P882P|SYT5_uc002qjm.1_5'Flank|SYT5_uc002qjp.2_5'Flank|SYT5_uc002qjn.1_5'Flank|SYT5_uc002qjo.1_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1060	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GCACCATCAACGGCCGACTCT	0.637													T	55693402	T	T	55693402	2	4	207	1	0	0	0	0	0	0	0	1	12803	523	19	1		1	PTPRH	19	55693402	Silent	SNP	C	TCGA-28-2514-01A-02D-1494-08	198320	55693402	3435581	55	14601											
ZNF337	26152	broad.mit.edu	37	chr20	25666266	25666266	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacttccccttgctctagccGcctgatgagttctggtttag	9	13	2	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr20:25666266G>A	uc002wva.2	-	3	709	c.187C>T	c.(187-189)CGG>TGG	p.R63W	ZNF337_uc010ztg.1_Intron|ZNF337_uc002wvb.2_Missense_Mutation_p.R63W|ZNF337_uc002wvc.2_Missense_Mutation_p.R63W	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCTCTAGCCGCCTGATGAGT	0.577													A	25666266	A	A	25666266	3	1	207	1	0	0	0	0	1	0	0	0	17850	1086	38	1	2076	1	ZNF337	20	25666266	Missense_Mutation	SNP	G	TCGA-28-2514-01A-02D-1494-08		25666266	37359254	56	14602											
STAU1	6780	broad.mit.edu	37	chr20	47741010	47741010	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctcaagaacagctatggCggcatttttctttgaaatct	7	10	3	2			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chr20:47741010C>T	uc002xud.2	-	7	1135	c.724G>A	c.(724-726)GCC>ACC	p.A242T	STAU1_uc002xua.2_Missense_Mutation_p.A161T|STAU1_uc002xub.2_Missense_Mutation_p.A167T|STAU1_uc002xuc.2_Missense_Mutation_p.A161T|STAU1_uc002xue.2_Missense_Mutation_p.A161T|STAU1_uc002xuf.2_Missense_Mutation_p.A167T|STAU1_uc002xug.2_Missense_Mutation_p.A242T	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	242	DRBM 2.					microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding	p.A242T(1)		ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			ACAGCTATGGCGGCATTTTTC	0.468													T	47741010	T	T	47741010	3	4	207	1	0	0	0	0	1	0	0	0	15271	768	27	1	1041	1	STAU1	20	47741010	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08	22074744	47741010	15284510	57	14603											
SERPINA7	6906	broad.mit.edu	37	chrX	105280734	105280734	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagccatgctggatctctaCcattggagtgtctgtgaggt	13	8	2	1			TCGA-28-2514-01A-02D-1494-08	TCGA-28-2514-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	6eef4a0e-3fef-4529-8193-21b380d96344	cebad0a3-5b2f-4236-baff-dc3cfb5e886f	g.chrX:105280734C>T	uc004eme.1	-	1	332	c.316G>A	c.(316-318)GTA>ATA	p.V106I	SERPINA7_uc010npd.2_Missense_Mutation_p.V106I|SERPINA7_uc010npe.1_Missense_Mutation_p.V106I	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	106					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	TGGATCTCTACCATTGGAGTG	0.478													T	105280734	T	T	105280734	3	4	207	1	0	0	0	0	1	0	0	0	14094	507	18	3	947	3	SERPINA7	23	105280734	Missense_Mutation	SNP	C	TCGA-28-2514-01A-02D-1494-08		105280734	49989826	58	14604											
YOD1	55432	broad.mit.edu	37	chr1	207224090	207224090	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	attgctgagatccaggcactCgggagggtatccgacgagga	15	9	0	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr1:207224090C>T	uc001hfe.1	-	1	333	c.286G>A	c.(286-288)GAG>AAG	p.E96K	PFKFB2_uc010psc.1_Intron|YOD1_uc001hff.1_Missense_Mutation_p.E52K	NM_018566	NP_061036	Q5VVQ6	OTU1_HUMAN	YOD1 OTU deubiquinating enzyme 1 homolog	96	UBX-like.				cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1	Prostate(682;0.19)					TCCAGGCACTCGGGAGGGTAT	0.632											OREG0014189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	207224090	T	T	207224090	3	4	208	1	0	0	0	0	1	0	0	0	17485	893	31	2	768	2	YOD1	1	207224090	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08		207224090	42026531	1	14605											
SLC35F3	148641	broad.mit.edu	37	chr1	234455909	234455909	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgatgtctcttggaatcGtcctcagcatacctgtgaat	8	11	3	2	rs149597390		TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr1:234455909G>A	uc001hwa.1	+	6	1234	c.1006G>A	c.(1006-1008)GTC>ATC	p.V336I	SLC35F3_uc001hvy.1_Missense_Mutation_p.V405I	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	336	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TCTTGGAATCGTCCTCAGCAT	0.294													A	234455909	A	A	234455909	3	1	208	1	0	0	0	0	1	0	0	0	14590	1145	40	1	1239	1	SLC35F3	1	234455909	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08	27231819	234455909	14794712	2	14606											
OR2W5	441932	broad.mit.edu	37	chr1	247654793	247654793	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggttgtcatgtcccatgacCgctatgtggccgtctgccgg	13	12	2	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr1:247654793C>T	uc001icz.1	+	1	364	c.364C>T	c.(364-366)CGC>TGC	p.R122C		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GTCCCATGACCGCTATGTGGC	0.587													T	247654793	T	T	247654793	3	4	208	1	0	0	0	0	1	0	0	0	11034	652	23	2	366	2	OR2W5	1	247654793	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08	13198884	247654793	1595828	3	14607											
IL1A	3552	broad.mit.edu	37	chr2	113532647	113532647	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagtgagactccagacctaCgcctggttttccagtatctg	9	12	1	2	rs3783588		TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr2:113532647C>T	uc002tig.2	-	7	1773	c.813G>A	c.(811-813)GCG>GCA	p.A271A		NM_000575	NP_000566	P01583	IL1A_HUMAN	interleukin 1, alpha proprotein	271					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			lung(1)	1						TCCAGACCTACGCCTGGTTTT	0.458													T	113532647	T	T	113532647	2	4	208	1	0	0	0	0	0	0	0	1	7650	523	19	1		1	IL1A	2	113532647	Silent	SNP	C	TCGA-28-5204-01A-01D-1486-08		113532647	129666726	4	14608											
TTN	7273	broad.mit.edu	37	chr2	179448473	179448473	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactcttcctggggaatctgGtgaggtgcagtattgcaccg	13	9	2	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr2:179448473G>A	uc010zfg.1	-	261	57956	c.57732C>T	c.(57730-57732)CAC>CAT	p.H19244H	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.H12939H|TTN_uc010zfi.1_Silent_p.H12872H|TTN_uc010zfj.1_Silent_p.H12747H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20171							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGGAATCTGGTGAGGTGCAG	0.463													A	179448473	A	A	179448473	2	1	208	1	0	0	0	0	0	0	0	1	16732	1252	44	3		3	TTN	2	179448473	Silent	SNP	G	TCGA-28-5204-01A-01D-1486-08	65915826	179448473	63750900	5	14609											
XPC	7508	broad.mit.edu	37	chr3	14197915	14197915	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctcatatttcaggagatgCcgcttcagggcatacagagg	12	10	3	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr3:14197915C>T	uc011ave.1	-	10	2057	c.1953G>A	c.(1951-1953)CGG>CGA	p.R651R	XPC_uc011avf.1_Silent_p.R458R|XPC_uc011avg.1_Silent_p.R614R	NM_004628	NP_004619	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	651	Minimal sensor domain involved in damage recognition.|DNA-binding; preference for heteroduplex DNA.|Interaction with RAD23B.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			ovary(2)|breast(1)	3						TCAGGAGATGCCGCTTCAGGG	0.532			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				T	14197915	T	T	14197915	2	4	208	1	0	0	0	0	0	0	0	1	17438	726	26	3		3	XPC	3	14197915	Silent	SNP	C	TCGA-28-5204-01A-01D-1486-08		14197915	183824515	6	14610											
TMPRSS7	344805	broad.mit.edu	37	chr3	111769547	111769547	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acacagtgttggtcaaagacAtcactggctttgaagggaaa	11	7	2	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr3:111769547A>G	uc010hqb.2	+	7	912	c.742A>G	c.(742-744)ATC>GTC	p.I248V	TMPRSS7_uc011bhr.1_Missense_Mutation_p.I103V	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	374	Extracellular (Potential).|CUB 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						GGTCAAAGACATCACTGGCTT	0.403													G	111769547	G	G	111769547	3	3	208	1	0	0	0	0	1	0	0	0	16249	217	8	4	764	4	TMPRSS7	3	111769547	Missense_Mutation	SNP	A	TCGA-28-5204-01A-01D-1486-08	97571632	111769547	86252883	7	14611											
RPL22L1	200916	broad.mit.edu	37	chr3	170584263	170584263	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgcaaccactcgaagccaaTcacgaagattgttcttctta	6	11	3	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr3:170584263T>C	uc003fhc.3	-	4	364	c.275A>G	c.(274-276)GAT>GGT	p.D92G	RPL22L1_uc003fhb.3_RNA	NM_001099645	NP_001093115	Q6P5R6	RL22L_HUMAN	ribosomal protein L22-like 1	92					translation	ribosome	structural constituent of ribosome				0	all_cancers(22;1.96e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.137)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			TCGAAGCCAATCACGAAGATT	0.353													C	170584263	C	C	170584263	3	2	208	1	0	0	0	0	1	0	0	0	13569	1435	50	4	97	4	RPL22L1	3	170584263	Missense_Mutation	SNP	T	TCGA-28-5204-01A-01D-1486-08	58814716	170584263	27438167	8	14612											
HRG	3273	broad.mit.edu	37	chr3	186390618	186390618	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttcgtggacttctctgtgCggaactgccccagacaccat	9	14	1	1	rs140916341		TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr3:186390618C>T	uc003fqq.2	+	5	624	c.601C>T	c.(601-603)CGG>TGG	p.R201W		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	201	Cystatin 2.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CTTCTCTGTGCGGAACTGCCC	0.403													T	186390618	T	T	186390618	3	4	208	1	0	0	0	0	1	0	0	0	7354	759	27	1	619	1	HRG	3	186390618	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08	15806355	186390618	11631812	9	14613											
CNOT6L	246175	broad.mit.edu	37	chr4	78665959	78665959	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtttaatgcccaggatggGcaatagccatatagctgccg	11	10	0	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr4:78665959G>A	uc011ccd.1	-	7	761	c.630C>T	c.(628-630)TGC>TGT	p.C210C	CNOT6L_uc003hks.2_Silent_p.C210C|CNOT6L_uc003hkt.1_Silent_p.C53C|CNOT6L_uc011cce.1_Intron	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	210					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						CCCAGGATGGGCAATAGCCAT	0.393													A	78665959	A	A	78665959	2	1	208	1	0	0	0	0	0	0	0	1	3623	1195	42	3		3	CNOT6L	4	78665959	Silent	SNP	G	TCGA-28-5204-01A-01D-1486-08		78665959	112488317	10	14614											
PLCXD3	345557	broad.mit.edu	37	chr5	41382448	41382448	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctgggcttggtggaaattcGaagatcaaaataacgaattc	10	6	2	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr5:41382448G>A	uc003jmm.1	-	2	394	c.292C>T	c.(292-294)CGA>TGA	p.R98*		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	98	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						GTGGAAATTCGAAGATCAAAA	0.443													A	41382448	A	A	41382448	4	1	208	1	0	0	0	0	0	1	0	0	12043	1066	37	2	681	2	PLCXD3	5	41382448	Nonsense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08		41382448	139532812	11	14615											
ERAP2	64167	broad.mit.edu	37	chr5	96239220	96239220	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaccacacacttctcagaccTaaggacagagtaggtctgat	8	11	2	3	rs115987752	by1000genomes	TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr5:96239220T>C	uc003kmq.2	+	13	2678	c.1968T>C	c.(1966-1968)CCT>CCC	p.P656P	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Silent_p.P656P|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Silent_p.P605P|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	656	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		TTCTCAGACCTAAGGACAGAG	0.418													C	96239220	C	C	96239220	2	2	208	1	0	0	0	0	0	0	0	1	5204	1509	53	4		4	ERAP2	5	96239220	Silent	SNP	T	TCGA-28-5204-01A-01D-1486-08	54856772	96239220	84676040	12	14616											
OOEP	441161	broad.mit.edu	37	chr6	74079407	74079407	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccggaaaccaccagggccGgatgcgaatctgtggcggcg	15	13	1	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr6:74079407G>A	uc003pgu.3	-	1	109	c.109C>T	c.(109-111)CGG>TGG	p.R37W	OOEP_uc003pgv.3_Intron	NM_001080507	NP_001073976	A6NGQ2	OOEP_HUMAN	oocyte expressed protein homolog	37						cytoplasm					0						CACCAGGGCCGGATGCGAATC	0.622													A	74079407	A	A	74079407	3	1	208	1	0	0	0	0	1	0	0	0	10870	1115	39	2	352	2	OOEP	6	74079407	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08		74079407	97035660	13	14617											
UST	10090	broad.mit.edu	37	chr6	149342488	149342488	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaatgggcccttgagagaGcaaagctgaacgtgaatgaa	14	6	0	6			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr6:149342488G>A	uc003qmg.2	+	7	1104	c.808G>A	c.(808-810)GCA>ACA	p.A270T		NM_005715	NP_005706	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	270	Lumenal (Potential).				protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			ovary(2)	2		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		CCTTGAGAGAGCAAAGCTGAA	0.388													A	149342488	A	A	149342488	3	1	208	1	0	0	0	0	1	0	0	0	17090	971	34	3	834	3	UST	6	149342488	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08	75263081	149342488	21772579	14	14618											
CALN1	83698	broad.mit.edu	37	chr7	71571179	71571179	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgatggccagctccacctcGcttggcatgtaccccaaaga	9	14	0	2	rs139754746		TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr7:71571179G>A	uc003twa.3	-	3	746	c.219C>T	c.(217-219)AGC>AGT	p.S73S	CALN1_uc003twb.3_Silent_p.S115S|CALN1_uc003twc.3_Silent_p.S73S	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	73	EF-hand 2.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				GCTCCACCTCGCTTGGCATGT	0.592													A	71571179	A	A	71571179	2	1	208	1	0	0	0	0	0	0	0	1	2591	1078	38	1		1	CALN1	7	71571179	Silent	SNP	G	TCGA-28-5204-01A-01D-1486-08		71571179	87567484	15	14619											
GNAT3	346562	broad.mit.edu	37	chr7	80103615	80103615	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtttcaatgattccagtcGttttcactcgagaatggaga	10	7	2	3			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr7:80103615G>A	uc011kgu.1	-	5	542	c.542C>T	c.(541-543)ACG>ATG	p.T181M	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	181	GTP (By similarity).	Magnesium (By similarity).			detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						GATTCCAGTCGTTTTCACTCG	0.343													A	80103615	A	A	80103615	3	1	208	1	0	0	0	0	1	0	0	0	6513	1145	40	1	536	1	GNAT3	7	80103615	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08	8532436	80103615	79035048	16	14620											
TRRAP	8295	broad.mit.edu	37	chr7	98609721	98609721	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcattctgaaaacggttctcCgggacgagatcattgcttgg	12	9	3	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr7:98609721C>T	uc003upp.2	+	72	11532	c.11323C>T	c.(11323-11325)CGG>TGG	p.R3775W	TRRAP_uc011kis.1_Missense_Mutation_p.R3746W|TRRAP_uc003upr.2_Missense_Mutation_p.R3481W|TRRAP_uc003ups.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3775	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AACGGTTCTCCGGGACGAGAT	0.547													T	98609721	T	T	98609721	3	4	208	1	0	0	0	0	1	0	0	0	16598	643	23	2	11514	2	TRRAP	7	98609721	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08	18506106	98609721	60528942	17	14621											
GJC3	349149	broad.mit.edu	37	chr7	99521178	99521178	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	catctccaactcaggcatctCtgggtccaactggtctttgt	8	13	4	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr7:99521178C>G	uc011kjd.1	-	2	830	c.830G>C	c.(829-831)AGA>ACA	p.R277T		NM_181538	NP_853516	Q8NFK1	CXG3_HUMAN	gap junction protein, gamma 3, 30.2kDa	277	Cytoplasmic (Potential).					connexon complex|integral to membrane				ovary(1)	1	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					tcaggcatctctgggtccaac	0													G	99521178	G	G	99521178	3	3	208	1	0	0	0	0	1	0	0	0	6416	913	32	5	13	5	GJC3	7	99521178	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08	911457	99521178	59617485	18	14622											
MUC17	140453	broad.mit.edu	37	chr7	100684383	100684383	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccattaactagtgtacctgTcagcaacacgccggtggcca	9	13	1	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr7:100684383T>C	uc003uxp.1	+	3	9739	c.9686T>C	c.(9685-9687)GTC>GCC	p.V3229A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3229	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|52.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGTGTACCTGTCAGCAACACG	0.478													C	100684383	C	C	100684383	3	2	208	1	0	0	0	0	1	0	0	0	9974	1667	58	4	9696	4	MUC17	7	100684383	Missense_Mutation	SNP	T	TCGA-28-5204-01A-01D-1486-08	1163205	100684383	58454280	19	14623											
ADAM2	2515	broad.mit.edu	37	chr8	39678526	39678526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caattaatcacctacctctaCgctttgtaatttaaaggaca	4	10	2	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr8:39678526C>T	uc003xnj.2	-	6	583	c.508G>A	c.(508-510)GTA>ATA	p.V170I	ADAM2_uc003xnk.2_Missense_Mutation_p.V170I|ADAM2_uc011lck.1_Missense_Mutation_p.V170I|ADAM2_uc003xnl.2_Missense_Mutation_p.V170I	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	170				V -> A (in Ref. 2; AAD04206).	cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CCTACCTCTACGCTTTGTAAT	0.294													T	39678526	T	T	39678526	3	4	208	1	0	0	0	0	1	0	0	0	241	536	19	1	1759	1	ADAM2	8	39678526	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08		39678526	106685496	20	14624											
RORB	6096	broad.mit.edu	37	chr9	77249548	77249548	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cttctctttttccctcaaggGattctttaggaggagccagc	9	11	3	0	rs143312543		TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr9:77249548G>T	uc004aji.2	+	3	177	c.128G>T	c.(127-129)GGA>GTA	p.G43V	RORB_uc004ajh.2_Missense_Mutation_p.G32V	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	43	Nuclear receptor.				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.G32E(1)		ovary(2)|lung(1)|skin(1)	4						TCCCTCAAGGGATTCTTTAGG	0.413													T	77249548	T	T	77249548	3	4	208	1	0	0	0	0	1	0	0	0	13529	1188	41	5	105	5	RORB	9	77249548	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08		77249548	63963883	21	14625											
BICD2	23299	broad.mit.edu	37	chr9	95481024	95481024	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggtgcttgatctggtcacGgatgatagcgatcaggttgt	14	7	3	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr9:95481024G>A	uc004aso.1	-	5	1960	c.1903C>T	c.(1903-1905)CGT>TGT	p.R635C	BICD2_uc004asp.1_Missense_Mutation_p.R635C	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	635					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						ATCTGGTCACGGATGATAGCG	0.652													A	95481024	A	A	95481024	3	1	208	1	0	0	0	0	1	0	0	0	1429	1116	39	2	686	2	BICD2	9	95481024	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08	18231476	95481024	45732407	22	14626											
CYLC2	1539	broad.mit.edu	37	chr9	105767590	105767590	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggtaaaaaggattcaaagaAgggcaaggattcagccatag	12	5	2	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr9:105767590A>C	uc004bbs.2	+	5	747	c.677A>C	c.(676-678)AAG>ACG	p.K226T		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	226	3 X approximate tandem repeats.|31 X 3 AA repeats of K-K-X.|3.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				GATTCAAAGAAGGGCAAGGAT	0.363													C	105767590	C	C	105767590	3	2	208	1	0	0	0	0	1	0	0	0	4142	72	3	5	695	5	CYLC2	9	105767590	Missense_Mutation	SNP	A	TCGA-28-5204-01A-01D-1486-08	10286566	105767590	35445841	23	14627											
TAF3	83860	broad.mit.edu	37	chr10	8007617	8007625	+	In_Frame_Del	DEL	AGAAGGAGA	-	-													gaagaaaaagaaggaaaaagAgaaggagaagaaggagaagg							TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr10:8007617_8007625delAGAAGGAGA	uc010qbd.1	+	3	2144_2152	c.2144_2152delAGAAGGAGA	c.(2143-2154)GAGAAGGAGAAG>GAG	p.KEK719del		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	719_721	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						aaggaaaaagagaaggagaagaaggagaa	0.115													-	8007625	-	-	8007617	7	5	208	1	0	1	0	1	0	0	0	0	15522	304	11	0	2154	0	TAF3	10	8007617	In_Frame_Del	DEL	AGAAGGAGA	TCGA-28-5204-01A-01D-1486-08		8007617	127527130	24	14628											
FAM13C	220965	broad.mit.edu	37	chr10	61029825	61029825	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagtggaggtcttctggtgCactgtcggcctcattctgcc	13	11	4	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr10:61029825C>T	uc001jkn.2	-	8	771	c.637G>A	c.(637-639)GCA>ACA	p.A213T	FAM13C_uc001jko.2_Missense_Mutation_p.A213T|FAM13C_uc010qid.1_Missense_Mutation_p.A130T|FAM13C_uc010qie.1_Missense_Mutation_p.A130T|FAM13C_uc010qif.1_Missense_Mutation_p.A235T|FAM13C_uc001jkp.2_Missense_Mutation_p.A130T	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	213										ovary(2)	2						TCTTCTGGTGCACTGTCGGCC	0.532													T	61029825	T	T	61029825	3	4	208	1	0	0	0	0	1	0	0	0	5454	710	25	3	1152	3	FAM13C	10	61029825	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08	53022208	61029825	74504922	25	14629											
RTKN2	219790	broad.mit.edu	37	chr10	63957685	63957685	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttctatacttgtgcctgcagCcatgatctagggtccagaat	9	10	2	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr10:63957685C>G	uc001jlw.2	-	12	1909	c.1812G>C	c.(1810-1812)TGG>TGC	p.W604C	RTKN2_uc009xpf.1_Intron|RTKN2_uc001jlv.2_Missense_Mutation_p.W258C	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	604					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					GTGCCTGCAGCCATGATCTAG	0.378													G	63957685	G	G	63957685	3	3	208	1	0	0	0	0	1	0	0	0	13723	740	26	5	21	5	RTKN2	10	63957685	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08	2927860	63957685	71577062	26	14630											
OR51A2	401667	broad.mit.edu	37	chr11	4976153	4976153	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagagacatgcccggcaaagCggtggacaacggccaggttg	16	10	0	1	rs61744535		TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr11:4976153C>T	uc010qyt.1	-	1	791	c.791G>A	c.(790-792)CGC>CAC	p.R264H		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCGGCAAAGCGGTGGACAAC	0.453													T	4976153	T	T	4976153	3	4	208	1	0	0	0	0	1	0	0	0	11086	768	27	1	152	1	OR51A2	11	4976153	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08		4976153	130030363	27	14631											
OR4C12	283093	broad.mit.edu	37	chr11	50003720	50003720	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcaggatgatctcagtagcAccaaaaatgtgttctgcata	9	8	2	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr11:50003720A>G	uc010ria.1	-	1	318	c.318T>C	c.(316-318)GGT>GGC	p.G106G		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TCTCAGTAGCACCAAAAATGT	0.453													G	50003720	G	G	50003720	2	3	208	1	0	0	0	0	0	0	0	1	11046	146	6	4		4	OR4C12	11	50003720	Silent	SNP	A	TCGA-28-5204-01A-01D-1486-08	45027567	50003720	85002796	28	14632											
CARD16	114769	broad.mit.edu	37	chr11	104912141	104912141	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgaagactatgataatttatGagttccagtttgcaactctt	7	6	1	4			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr11:104912141G>A	uc001pip.1	-	3	607	c.580C>T	c.(580-582)CAT>TAT	p.H194Y	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_3'UTR	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	194					regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						GATAATTTATGAGTTCCAGTT	0.398													A	104912141	A	A	104912141	3	1	208	1	0	0	0	0	1	0	0	0	2647	1290	45	3	17	3	CARD16	11	104912141	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08	54908421	104912141	30094375	29	14633											
SLC38A1	81539	broad.mit.edu	37	chr12	46594890	46594890	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaattacttaccatagaatgTcaagtagccaaaaatggcag	7	7	1	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr12:46594890T>C	uc001rpa.2	-	13	1252	c.994A>G	c.(994-996)ACA>GCA	p.T332A	SLC38A1_uc001rpb.2_Missense_Mutation_p.T332A|SLC38A1_uc001rpc.2_Missense_Mutation_p.T332A|SLC38A1_uc001rpd.2_Missense_Mutation_p.T332A|SLC38A1_uc001rpe.2_Missense_Mutation_p.T332A|SLC38A1_uc010slh.1_Missense_Mutation_p.T305A|SLC38A1_uc009zkj.1_Missense_Mutation_p.T332A	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	332	Helical; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			CCATAGAATGTCAAGTAGCCA	0.294													C	46594890	C	C	46594890	3	2	208	1	0	0	0	0	1	0	0	0	14601	1667	58	4	489	4	SLC38A1	12	46594890	Missense_Mutation	SNP	T	TCGA-28-5204-01A-01D-1486-08		46594890	87257005	30	14634											
TRPC4	7223	broad.mit.edu	37	chr13	38266163	38266163	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccacggtaatatcatccactCgacgatggttggtggtggac	12	10	1	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr13:38266163C>T	uc001uws.2	-	4	1442	c.1207G>A	c.(1207-1209)GAG>AAG	p.E403K	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Missense_Mutation_p.E403K|TRPC4_uc010tey.1_Missense_Mutation_p.E403K|TRPC4_uc010abw.2_Missense_Mutation_p.E230K|TRPC4_uc010abx.2_Missense_Mutation_p.E403K|TRPC4_uc010aby.2_Missense_Mutation_p.E403K	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	403	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ATCATCCACTCGACGATGGTT	0.438													T	38266163	T	T	38266163	3	4	208	1	0	0	0	0	1	0	0	0	16577	893	31	2	1773	2	TRPC4	13	38266163	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08		38266163	76903715	31	14635											
DACH1	1602	broad.mit.edu	37	chr13	72053352	72053352	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctcaagtgtttcccttagttCtctttcccttaaaaaatcca	3	12	2	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr13:72053352C>A	uc010thn.1	-	9	2242	c.1819G>T	c.(1819-1821)GAA>TAA	p.E607*	DACH1_uc010tho.1_Nonsense_Mutation_p.E459*|DACH1_uc010thp.1_Nonsense_Mutation_p.E405*	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	659	DACHbox-C.|Potential.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TCCCTTAGTTCTCTTTCCCTT	0.363													A	72053352	A	A	72053352	4	1	208	1	0	0	0	0	0	1	0	0	4220	922	32	5	317	5	DACH1	13	72053352	Nonsense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08	33787189	72053352	43116526	32	14636											
ACAN	176	broad.mit.edu	37	chr15	89400787	89400787	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggacttccatctggattcccAactgtttccctagtggattc	8	12	1	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr15:89400787A>T	uc010upo.1	+	12	5345	c.4971A>T	c.(4969-4971)CCA>CCT	p.P1657P	ACAN_uc010upp.1_Silent_p.P1657P|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1657					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGATTCCCAACTGTTTCCC	0.537													T	89400787	T	T	89400787	2	4	208	1	0	0	0	0	0	0	0	1	117	117	5	5		5	ACAN	15	89400787	Silent	SNP	A	TCGA-28-5204-01A-01D-1486-08		89400787	13130605	33	14637											
DPEP1	1800	broad.mit.edu	37	chr16	89703308	89703308	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggtggacacgggagacagcGagccccagagccaaggcttg	16	11	0	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr16:89703308G>A	uc010cin.2	+	6	759	c.556G>A	c.(556-558)GAG>AAG	p.E186K	DPEP1_uc002fnr.3_Missense_Mutation_p.E186K|DPEP1_uc002fns.3_Missense_Mutation_p.E186K	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	186					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	GGGAGACAGCGAGCCCCAGAG	0.632													A	89703308	A	A	89703308	3	1	208	1	0	0	0	0	1	0	0	0	4713	1059	37	2	574	2	DPEP1	16	89703308	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08		89703308	651445	34	14638											
PIK3R5	23533	broad.mit.edu	37	chr17	8792501	8792501	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtgtagcacctggcgacagGgatggggatggtgtggagct	20	6	0	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr17:8792501G>T	uc002glt.2	-	9	917	c.850C>A	c.(850-852)CCT>ACT	p.P284T	PIK3R5_uc010vuz.1_Missense_Mutation_p.P284T|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Silent_p.S232S|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	284				AKTLAELEDIFTETAEAQELASGIGDAAEARRWLRTKLQAV GEKAGFPGVLDTAKPGKLHTIPIPVARCYTYSWSQDS -> TLQNQGSSIPSPSLSPGATPTAGARTALTSCRKSCSRNRSC SSQGSWEMMKRRKRRRRRWRRTWKLMGTVPREIPCSP (in Ref. 6; AAW63122).	platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						CTGGCGACAGGGATGGGGATG	0.483													T	8792501	T	T	8792501	3	4	208	1	0	0	0	0	1	0	0	0	11922	1232	43	5	1836	5	PIK3R5	17	8792501	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08		8792501	72402709	35	14639											
DBF4B	80174	broad.mit.edu	37	chr17	42828248	42828248	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcggacattcctgttaaggGcccactcctcttccctgaag	10	14	1	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr17:42828248G>A	uc002ihf.2	+	14	1688	c.1475G>A	c.(1474-1476)GGC>GAC	p.G492D	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	492					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				CCTGTTAAGGGCCCACTCCTC	0.592													A	42828248	A	A	42828248	3	1	208	1	0	0	0	0	1	0	0	0	4249	1203	42	3	1574	3	DBF4B	17	42828248	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08	34035747	42828248	38366962	36	14640											
RGS9	8787	broad.mit.edu	37	chr17	63206625	63206625	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctccaccctcccttttatgCggcgtcacctgcgctccagc	8	19	1	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr17:63206625C>T	uc002jfe.2	+	17	1419	c.1309C>T	c.(1309-1311)CGG>TGG	p.R437W	RGS9_uc010dem.2_Missense_Mutation_p.R434W|RGS9_uc002jfd.2_Missense_Mutation_p.R434W|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.R208W	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	437					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CCCTTTTATGCGGCGTCACCT	0.572													T	63206625	T	T	63206625	3	4	208	1	0	0	0	0	1	0	0	0	13313	759	27	1	1375	1	RGS9	17	63206625	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08	20378377	63206625	17988585	37	14641											
ABCA5	23461	broad.mit.edu	37	chr17	67264191	67264191	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aattttaaaaactatatcagTaatttcctgaaagacaacca	3	7	1	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr17:67264191T>A	uc002jif.2	-	22	4255	c.3037A>T	c.(3037-3039)ACT>TCT	p.T1013S	ABCA5_uc002jib.2_5'UTR|ABCA5_uc002jic.2_Missense_Mutation_p.T236S|ABCA5_uc002jid.2_5'UTR|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.T1013S	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	1013					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					ACTATATCAGTAATTTCCTGA	0.274													A	67264191	A	A	67264191	3	1	208	1	0	0	0	0	1	0	0	0	35	1638	57	5	1959	5	ABCA5	17	67264191	Missense_Mutation	SNP	T	TCGA-28-5204-01A-01D-1486-08	4057566	67264191	13931019	38	14642											
TNRC6C	57690	broad.mit.edu	37	chr17	76083173	76083173	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acctttgctccttaccctctCggtgagtgtcccatggtctt	8	14	2	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr17:76083173C>T	uc002jud.2	+	14	4401	c.3801C>T	c.(3799-3801)CTC>CTT	p.L1267L	TNRC6C_uc002juf.2_Silent_p.L1264L	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1267					gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CTTACCCTCTCGGTGAGTGTC	0.572													T	76083173	T	T	76083173	2	4	208	1	0	0	0	0	0	0	0	1	16339	898	31	2		2	TNRC6C	17	76083173	Silent	SNP	C	TCGA-28-5204-01A-01D-1486-08	8818982	76083173	5112037	39	14643											
ZNF554	115196	broad.mit.edu	37	chr19	2834236	2834236	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgtgggaaggtgttcaacCggaggcattctttgagcgaa	15	6	2	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr19:2834236C>T	uc002lwm.2	+	5	1201	c.1003C>T	c.(1003-1005)CGG>TGG	p.R335W	ZNF554_uc002lwl.2_Missense_Mutation_p.R284W	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	335	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGTTCAACCGGAGGCATTC	0.532													T	2834236	T	T	2834236	3	4	208	1	0	0	0	0	1	0	0	0	17982	643	23	2	1021	2	ZNF554	19	2834236	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08		2834236	56294747	40	14644											
LDLR	3949	broad.mit.edu	37	chr19	11222312	11222312	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacgaaggcctgcaaggctGtgggtgagcacgggaaggcg	18	9	0	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr19:11222312G>A	uc002mqk.3	+	8	1351	c.1183G>A	c.(1183-1185)GTG>ATG	p.V395M	LDLR_uc010xlk.1_Missense_Mutation_p.V395M|LDLR_uc010xll.1_Missense_Mutation_p.V354M|LDLR_uc010xlm.1_Missense_Mutation_p.V248M|LDLR_uc010xln.1_Missense_Mutation_p.V268M|LDLR_uc010xlo.1_Missense_Mutation_p.V227M	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	395	Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CTGCAAGGCTGTGGGTGAGCA	0.632													A	11222312	A	A	11222312	3	1	208	1	0	0	0	0	1	0	0	0	8704	1377	48	3	1213	3	LDLR	19	11222312	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08	8388076	11222312	47906671	41	14645											
RYR1	6261	broad.mit.edu	37	chr19	39008083	39008083	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagacattggggggctggCcgagtcaggtgcccgctaca	17	11	1	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr19:39008083C>T	uc002oit.2	+	66	9900	c.9770C>T	c.(9769-9771)GCC>GTC	p.A3257V	RYR1_uc002oiu.2_Missense_Mutation_p.A3257V|RYR1_uc002oiv.1_Missense_Mutation_p.A177V|RYR1_uc010xuf.1_Missense_Mutation_p.A177V	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3257					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGGGGGCTGGCCGAGTCAGGT	0.657													T	39008083	T	T	39008083	3	4	208	1	0	0	0	0	1	0	0	0	13768	739	26	3	10032	3	RYR1	19	39008083	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08	27785771	39008083	20120900	42	14646											
ZNF235	9310	broad.mit.edu	37	chr19	44803797	44803797	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taaagttctccagcatcacaTctcggtacagcttcctctgg	7	13	4	0			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr19:44803797T>C	uc002oza.3	-	3	207	c.104A>G	c.(103-105)GAT>GGT	p.D35G	ZNF235_uc002oyx.1_RNA|ZNF235_uc010eji.2_Missense_Mutation_p.D35G|ZNF235_uc002ozb.3_Missense_Mutation_p.D35G|ZNF235_uc010xwx.1_5'UTR	NM_004234	NP_004225	Q14590	ZN235_HUMAN	zinc finger protein 93 homolog	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)	3		Prostate(69;0.0352)|all_neural(266;0.116)				CAGCATCACATCTCGGTACAG	0.443													C	44803797	C	C	44803797	3	2	208	1	0	0	0	0	1	0	0	0	17785	1435	50	4	2124	4	ZNF235	19	44803797	Missense_Mutation	SNP	T	TCGA-28-5204-01A-01D-1486-08	5795714	44803797	14325186	43	14647											
FPR2	2358	broad.mit.edu	37	chr19	52272072	52272072	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatctgggtggctggattccGgatgacacgcacagtcacca	13	11	2	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr19:52272072G>A	uc002pxr.2	+	2	206	c.161G>A	c.(160-162)CGG>CAG	p.R54Q	FPR2_uc002pxs.3_Missense_Mutation_p.R54Q|FPR2_uc010epf.2_Missense_Mutation_p.R54Q	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	54	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						GCTGGATTCCGGATGACACGC	0.562													A	52272072	A	A	52272072	3	1	208	1	0	0	0	0	1	0	0	0	6039	1116	39	2	163	2	FPR2	19	52272072	Missense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08	7468275	52272072	6856911	44	14648											
UBE2M	9040	broad.mit.edu	37	chr19	59067682	59067682	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaccacctattcctactcaCcaagaagagatactgcaggc	6	14	1	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr19:59067682C>T	uc002qtl.3	-	5	1006	c.411_splice	c.e5+1	p.L137_splice	CHMP2A_uc002qti.2_5'Flank|CHMP2A_uc002qtj.2_5'Flank|CHMP2A_uc002qtk.2_5'Flank|LOC100131691_uc002qtm.2_5'Flank	NM_003969	NP_003960	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M						protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TTCCTACTCACCAAGAAGAGA	0.552													T	59067682	T	T	59067682	5	4	208	1	0	0	0	0	0	0	1	0	16862	521	18	3	147	3	UBE2M	19	59067682	Splice_Site	SNP	C	TCGA-28-5204-01A-01D-1486-08	6795610	59067682	61301	45	14649											
MATN4	8785	broad.mit.edu	37	chr20	43927050	43927050	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtagcgacccagagggaactCggtgcgcacgcggctcgaga	16	12	0	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr20:43927050C>T	uc002xnn.2	-	7	1373	c.1186G>A	c.(1186-1188)GAG>AAG	p.E396K	MATN4_uc002xno.2_Missense_Mutation_p.E355K|MATN4_uc002xnp.2_Missense_Mutation_p.E314K|MATN4_uc010zwr.1_Missense_Mutation_p.E344K|MATN4_uc002xnr.1_Missense_Mutation_p.E396K	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	437	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				AGAGGGAACTCGGTGCGCACG	0.657													T	43927050	T	T	43927050	3	4	208	1	0	0	0	0	1	0	0	0	9336	893	31	2	575	2	MATN4	20	43927050	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08		43927050	19098470	46	14650											
USP25	29761	broad.mit.edu	37	chr21	17199405	17199405	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaaaccatttactcagtccCggatacctccagatttgccc	5	15	1	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr21:17199405C>T	uc002yjy.1	+	14	1793	c.1576C>T	c.(1576-1578)CGG>TGG	p.R526W	USP25_uc011aby.1_Missense_Mutation_p.R526W|USP25_uc002yjz.1_Missense_Mutation_p.R526W|USP25_uc010gla.1_Intron	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	526					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TACTCAGTCCCGGATACCTCC	0.473													T	17199405	T	T	17199405	3	4	208	1	0	0	0	0	1	0	0	0	17053	643	23	2	1630	2	USP25	21	17199405	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08		17199405	30930490	47	14651											
NEFH	4744	broad.mit.edu	37	chr22	29886478	29886478	+	Frame_Shift_Del	DEL	C	-	-													accagcagagaagaaggaggCagcaccggagaaaaaagaca							TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr22:29886478delC	uc003afo.2	+	4	2920	c.2849delC	c.(2848-2850)GCAfs	p.A950fs	NEFH_uc003afp.2_Frame_Shift_Del_p.Q16fs	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	956	Tail.				cell death|nervous system development	neurofilament					0						AAGAAGGAGGCAGCACCGGAG	0.512													-	29886478	-	-	29886478	7	5	208	1	0	1	0	1	0	0	0	0	10314	710	25	0	2863	0	NEFH	22	29886478	Frame_Shift_Del	DEL	C	TCGA-28-5204-01A-01D-1486-08		29886478	21418088	48	14652											
GGA1	26088	broad.mit.edu	37	chr22	38016358	38016366	+	In_Frame_Del	DEL	AAAGAAGCA	-	-													gcagaggcctaccagatgctAaagaagcagggtgaggcaca							TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chr22:38016358_38016366delAAAGAAGCA	uc003atc.2	+	5	782_790	c.417_425delAAAGAAGCA	c.(415-426)CTAAAGAAGCAG>CTG	p.KKQ140del	GGA1_uc003atd.2_In_Frame_Del_p.KKQ140del|GGA1_uc003ate.2_In_Frame_Del_p.KKQ140del|GGA1_uc003atf.2_In_Frame_Del_p.KKQ67del	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	140_142	Interaction with ARF3.|VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					ACCAGATGCTAAAGAAGCAGGGTGAGGCA	0.617													-	38016366	-	-	38016358	7	5	208	1	0	1	0	1	0	0	0	0	6352	349	13	0	501	0	GGA1	22	38016358	In_Frame_Del	DEL	AAAGAAGCA	TCGA-28-5204-01A-01D-1486-08	8129880	38016358	13288208	49	14653											
KIAA2022	340533	broad.mit.edu	37	chrX	73961437	73961437	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctaaagagccgaccatcatcCatattgactggcccctgctg	8	14	1	2			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chrX:73961437C>T	uc004eby.2	-	3	3572	c.2955G>A	c.(2953-2955)ATG>ATA	p.M985I		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	985					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GACCATCATCCATATTGACTG	0.448													T	73961437	T	T	73961437	3	4	208	1	0	0	0	0	1	0	0	0	8269	594	21	3	1603	3	KIAA2022	23	73961437	Missense_Mutation	SNP	C	TCGA-28-5204-01A-01D-1486-08		73961437	81309123	50	14654											
IRS4	8471	broad.mit.edu	37	chrX	107977902	107977902	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	caggtctctggccaccacctGaaccgtgcccacctgcggtg	11	17	1	1			TCGA-28-5204-01A-01D-1486-08	TCGA-28-5204-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9590ee4-92d8-4afb-908e-0c816d2b82f3	3b890266-b1aa-401e-a5f2-5c35849a42f2	g.chrX:107977902G>T	uc004eoc.2	-	1	1706	c.1673C>A	c.(1672-1674)TCA>TAA	p.S558*		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	558						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GCCACCACCTGAACCGTGCCC	0.657													T	107977902	T	T	107977902	4	4	208	1	0	0	0	0	0	1	0	0	7842	1294	45	5	2104	5	IRS4	23	107977902	Nonsense_Mutation	SNP	G	TCGA-28-5204-01A-01D-1486-08	34016465	107977902	47292658	51	14655											
NOL9	79707	broad.mit.edu	37	chr1	6589196	6589196	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgggtaggggcgacatcagaGtgggtaatccggagtgcgac	18	7	1	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr1:6589196G>T	uc001ans.2	-	10	1702	c.1683C>A	c.(1681-1683)CAC>CAA	p.H561Q	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	561					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		CGACATCAGAGTGGGTAATCC	0.463													T	6589196	T	T	6589196	3	4	209	1	0	0	0	0	1	0	0	0	10528	1020	36	5	437	5	NOL9	1	6589196	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08		6589196	242661425	1	14656											
MACF1	23499	broad.mit.edu	37	chr1	39800817	39800817	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatttgggtgcaaggatcaaCgtaagccaagaatgtcttca	10	7	3	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr1:39800817C>T	uc010oiu.1	+	1	4008	c.3877C>T	c.(3877-3879)CGT>TGT	p.R1293C	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2858					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAAGGATCAACGTAAGCCAAG	0.398													T	39800817	T	T	39800817	3	4	209	1	0	0	0	0	1	0	0	0	9144	536	19	1	8648	1	MACF1	1	39800817	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	33211621	39800817	209449804	2	14657											
HYI	81888	broad.mit.edu	37	chr1	43917642	43917642	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caggaagtactgggggtcagTgatgcgggtgttgatgggct	19	5	1	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr1:43917642T>C	uc001cjo.2	-	4	639	c.469A>G	c.(469-471)ACT>GCT	p.T157A	KIAA0467_uc001cjk.1_3'UTR|KIAA0467_uc001cjl.1_3'UTR|HYI_uc001cjm.2_Missense_Mutation_p.T84A|HYI_uc001cjn.2_Missense_Mutation_p.T157A|HYI_uc001cjp.2_Missense_Mutation_p.T84A	NM_031207	NP_112484	Q5T013	HYI_HUMAN	hydroxypyruvate isomerase homolog	157							hydroxypyruvate isomerase activity			ovary(1)	1	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGGGGGTCAGTGATGCGGGTG	0.587													C	43917642	C	C	43917642	3	2	209	1	0	0	0	0	1	0	0	0	7468	1696	59	4	384	4	HYI	1	43917642	Missense_Mutation	SNP	T	TCGA-28-5207-01A-01D-1486-08	4116825	43917642	205332979	3	14658											
FCRL2	79368	broad.mit.edu	37	chr1	157740305	157740305	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cttaaaactgcactttggatAaggaaatctgagaatttttt	7	5	1	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr1:157740305A>T	uc001fre.2	-	3	263	c.204T>A	c.(202-204)CTT>CTA	p.L68L	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Silent_p.L68L|FCRL2_uc009wsp.2_Silent_p.L68L|FCRL2_uc010pia.1_Silent_p.L68L	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	68	Ig-like C2-type 1.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CACTTTGGATAAGGAAATCTG	0.338													T	157740305	T	T	157740305	2	4	209	1	0	0	0	0	0	0	0	1	5795	349	13	5		5	FCRL2	1	157740305	Silent	SNP	A	TCGA-28-5207-01A-01D-1486-08	113822663	157740305	91510316	4	14659											
ZBTB37	84614	broad.mit.edu	37	chr1	173840057	173840057	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gagtggcggaccgtgggggtCggagtgatgatgaagttaga	20	4	0	4			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr1:173840057C>T	uc009wwp.1	+	3	970	c.694C>T	c.(694-696)CGG>TGG	p.R232W	GAS5_uc001gjj.2_5'Flank|GAS5_uc001gjk.2_5'Flank|ZBTB37_uc001gjp.1_Missense_Mutation_p.R232W|ZBTB37_uc001gjq.3_Missense_Mutation_p.R232W|ZBTB37_uc001gjr.2_Missense_Mutation_p.R232W	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGTGGGGGTCGGAGTGATGA	0.522													T	173840057	T	T	173840057	3	4	209	1	0	0	0	0	1	0	0	0	17535	875	31	2	696	2	ZBTB37	1	173840057	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	16099752	173840057	75410564	5	14660											
HMCN1	83872	broad.mit.edu	37	chr1	186099745	186099745	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccccaccccaaccatccaGtggaacagaaagggagtgga	11	13	0	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr1:186099745G>A	uc001grq.1	+	85	13375	c.13146G>A	c.(13144-13146)CAG>CAA	p.Q4382Q	HMCN1_uc001grs.1_Translation_Start_Site	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4382	Ig-like C2-type 43.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAACCATCCAGTGGAACAGAA	0.488													A	186099745	A	A	186099745	2	1	209	1	0	0	0	0	0	0	0	1	7220	1020	36	3		3	HMCN1	1	186099745	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	12259688	186099745	63150876	6	14661											
ASPM	259266	broad.mit.edu	37	chr1	197062332	197062332	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gcagatttctgccgaagaaaGacctgccttcctttatatcc	7	12	1	3			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr1:197062332G>C	uc001gtu.2	-	21	9401	c.9144C>G	c.(9142-9144)GTC>GTG	p.V3048V	ASPM_uc001gtv.2_Silent_p.V1463V|ASPM_uc001gtw.3_Silent_p.V896V	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	3048	IQ 36.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GCCGAAGAAAGACCTGCCTTC	0.348													C	197062332	C	C	197062332	2	2	209	1	0	0	0	0	0	0	0	1	1056	929	33	5		5	ASPM	1	197062332	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	10962587	197062332	52188289	7	14662											
USH2A	7399	broad.mit.edu	37	chr1	216465647	216465647	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cattgacaaggtttacaattGaaagcgtaaacttgatcacc	7	8	1	3			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr1:216465647G>C	uc001hku.1	-	10	2097	c.1710C>G	c.(1708-1710)TTC>TTG	p.F570L	USH2A_uc001hkv.2_Missense_Mutation_p.F570L	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	570	Laminin EGF-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTTACAATTGAAAGCGTAAA	0.413										HNSCC(13;0.011)			C	216465647	C	C	216465647	3	2	209	1	0	0	0	0	1	0	0	0	17033	1281	45	5	14164	5	USH2A	1	216465647	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08	19403315	216465647	32784974	8	14663											
OR2T27	403239	broad.mit.edu	37	chr1	248814129	248814129	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agccaggggaaacgggcgttGctgaacaaacccagaaggat	14	9	0	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr1:248814129G>T	uc010pzo.1	-	1	57	c.57C>A	c.(55-57)AGC>AGA	p.S19R		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AACGGGCGTTGCTGAACAAAC	0.468													T	248814129	T	T	248814129	3	4	209	1	0	0	0	0	1	0	0	0	11021	1310	46	5	899	5	OR2T27	1	248814129	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08	32348482	248814129	436492	9	14664											
SNTG2	54221	broad.mit.edu	37	chr2	1271233	1271233	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccctattgcttcagcatcGtggccggccatgggaagagc	14	12	1	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr2:1271233G>A	uc002qwq.2	+	14	1302	c.1174G>A	c.(1174-1176)GTG>ATG	p.V392M	SNTG2_uc010ewi.2_Missense_Mutation_p.V265M	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	392	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CTTCAGCATCGTGGCCGGCCA	0.522													A	1271233	A	A	1271233	3	1	209	1	0	0	0	0	1	0	0	0	14875	1145	40	1	1228	1	SNTG2	2	1271233	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08		1271233	241928140	10	14665											
STRN	6801	broad.mit.edu	37	chr2	37152302	37152302	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctcctcacaagatccttcTtcaaattttcttggcccttc	3	15	4	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr2:37152302T>C	uc002rpn.2	-	2	293	c.284A>G	c.(283-285)AAG>AGG	p.K95R	STRN_uc010ezx.2_Missense_Mutation_p.K95R	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	95	Potential.				dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				AAGATCCTTCTTCAAATTTTC	0.353													C	37152302	C	C	37152302	3	2	209	1	0	0	0	0	1	0	0	0	15328	1609	56	4	2126	4	STRN	2	37152302	Missense_Mutation	SNP	T	TCGA-28-5207-01A-01D-1486-08	35881069	37152302	206047071	11	14666											
SOCS5	9655	broad.mit.edu	37	chr2	46987001	46987001	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agtttcgacgcccatgacccGtgtgtatttcactcctccac	7	15	1	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr2:46987001G>T	uc002rvf.2	+	2	1496	c.1332G>T	c.(1330-1332)CCG>CCT	p.P444P	SOCS5_uc010yoe.1_Silent_p.P413P|SOCS5_uc002rvg.2_Silent_p.P444P	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	444	SH2.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CCCATGACCCGTGTGTATTTC	0.443													T	46987001	T	T	46987001	2	4	209	1	0	0	0	0	0	0	0	1	14917	1132	40	5		5	SOCS5	2	46987001	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	9834699	46987001	196212372	12	14667											
IL1R1	3554	broad.mit.edu	37	chr2	102793083	102793083	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctttacacagggaccacagtCtgcaaagacaaggttctgga	10	10	2	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr2:102793083C>T	uc002tbq.2	+	12	1892	c.1574C>T	c.(1573-1575)TCT>TTT	p.S525F	IL1R1_uc010fix.2_Missense_Mutation_p.S494F|IL1R1_uc002tbr.2_Missense_Mutation_p.S525F	NM_000877	NP_000868	P14778	IL1R1_HUMAN	interleukin 1 receptor, type I precursor	525	TIR.|Cytoplasmic (Potential).				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			skin(1)	1					Anakinra(DB00026)	GGACCACAGTCTGCAAAGACA	0.468													T	102793083	T	T	102793083	3	4	209	1	0	0	0	0	1	0	0	0	7658	913	32	3	1612	3	IL1R1	2	102793083	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	55806082	102793083	140406290	13	14668											
LCT	3938	broad.mit.edu	37	chr2	136558294	136558294	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgactggcgcggtacacatcGttgtacagatgccaggcctc	12	12	0	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr2:136558294G>A	uc002tuu.1	-	12	4760	c.4749C>T	c.(4747-4749)AAC>AAT	p.N1583N		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1583	Extracellular (Potential).|4.|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGTACACATCGTTGTACAGAT	0.537													A	136558294	A	A	136558294	2	1	209	1	0	0	0	0	0	0	0	1	8693	1136	40	1		1	LCT	2	136558294	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	33765211	136558294	106641079	14	14669											
ARHGAP15	55843	broad.mit.edu	37	chr2	144381721	144381721	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagagaagctgaatttggaCgacagccagtgggaggacat	15	6	0	2	rs138120208		TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr2:144381721C>T	uc002tvm.3	+	12	1174	c.1023C>T	c.(1021-1023)GAC>GAT	p.D341D	ARHGAP15_uc002tvn.2_Silent_p.D107D	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	341	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		TGAATTTGGACGACAGCCAGT	0.448													T	144381721	T	T	144381721	2	4	209	1	0	0	0	0	0	0	0	1	866	535	19	1		1	ARHGAP15	2	144381721	Silent	SNP	C	TCGA-28-5207-01A-01D-1486-08	7823427	144381721	98817652	15	14670											
TTN	7273	broad.mit.edu	37	chr2	179647001	179647001	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatggggctttgggttgccGccaacttggcatccaaacac	11	12	0	0	rs141768043		TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr2:179647001G>A	uc010zfg.1	-	20	3542	c.3318C>T	c.(3316-3318)GGC>GGT	p.G1106G	TTN_uc010zfh.1_Silent_p.G1060G|TTN_uc010zfi.1_Silent_p.G1060G|TTN_uc010zfj.1_Silent_p.G1060G|TTN_uc002unb.2_Silent_p.G1106G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1106							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGGTTGCCGCCAACTTGGC	0.488													A	179647001	A	A	179647001	2	1	209	1	0	0	0	0	0	0	0	1	16732	1074	38	1		1	TTN	2	179647001	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	35265280	179647001	63552372	16	14671											
LRIG1	26018	broad.mit.edu	37	chr3	66432740	66432740	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gcctgagggccaccctcggtCctgaccacggtttcttgtcg	12	15	1	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr3:66432740C>A	uc003dmx.2	-	16	2588	c.2574G>T	c.(2572-2574)AGG>AGT	p.R858S	SLC25A26_uc011bft.1_Intron|LRIG1_uc011bfu.1_Missense_Mutation_p.R478S|LRIG1_uc003dmw.2_Missense_Mutation_p.R524S|LRIG1_uc010hnz.2_Missense_Mutation_p.R574S|LRIG1_uc010hoa.2_Missense_Mutation_p.R835S	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	858	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CACCCTCGGTCCTGACCACGG	0.552													A	66432740	A	A	66432740	3	1	209	1	0	0	0	0	1	0	0	0	8944	854	30	5	723	5	LRIG1	3	66432740	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08		66432740	131589690	17	14672											
STXBP5L	9515	broad.mit.edu	37	chr3	120957900	120957900	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catactttgcagattgtcctCcggatttgattctagtactg	8	9	1	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr3:120957900C>T	uc003eec.3	+	13	1407	c.1267C>T	c.(1267-1269)CCG>TCG	p.P423S	STXBP5L_uc011bji.1_Missense_Mutation_p.P423S	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	423	WD 8.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AGATTGTCCTCCGGATTTGAT	0.308													T	120957900	T	T	120957900	3	4	209	1	0	0	0	0	1	0	0	0	15356	855	30	3	1313	3	STXBP5L	3	120957900	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	54525160	120957900	77064530	18	14673											
SLC25A36	55186	broad.mit.edu	37	chr3	140692641	140692641	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actaaaaggattttatagggGcatgtctgcttcatatgctg	10	6	2	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr3:140692641G>A	uc003etr.2	+	6	771	c.536G>A	c.(535-537)GGC>GAC	p.G179D	SLC25A36_uc003ets.2_Missense_Mutation_p.G179D|SLC25A36_uc003etq.2_Missense_Mutation_p.G22D|SLC25A36_uc011bmz.1_Missense_Mutation_p.G153D	NM_001104647	NP_001098117	Q96CQ1	S2536_HUMAN	solute carrier family 25, member 36 isoform a	179	Solcar 2.				response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						TTTTATAGGGGCATGTCTGCT	0.368													A	140692641	A	A	140692641	3	1	209	1	0	0	0	0	1	0	0	0	14500	1203	42	3	558	3	SLC25A36	3	140692641	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08	19734741	140692641	57329789	19	14674											
BOD1L	259282	broad.mit.edu	37	chr4	13603517	13603517	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttcaactatttctgagtcTctacttaaagaaccatcaca	3	12	4	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr4:13603517T>G	uc003gmz.1	-	10	5124	c.5007A>C	c.(5005-5007)AGA>AGC	p.R1669S	BOD1L_uc010idr.1_Missense_Mutation_p.R1006S	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1669							DNA binding			ovary(5)|breast(1)	6						TTTCTGAGTCTCTACTTAAAG	0.373													G	13603517	G	G	13603517	3	3	209	1	0	0	0	0	1	0	0	0	1483	1548	54	5	4216	5	BOD1L	4	13603517	Missense_Mutation	SNP	T	TCGA-28-5207-01A-01D-1486-08		13603517	177550759	20	14675											
PAQR3	152559	broad.mit.edu	37	chr4	79856373	79856373	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcatatattcccagggtgaAgaagagaaagaaacccagca	10	8	1	4			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr4:79856373A>G	uc003hlp.1	-	2	454	c.250T>C	c.(250-252)TTC>CTC	p.F84L	PAQR3_uc003hlm.2_RNA|PAQR3_uc003hln.2_Intron|PAQR3_uc003hlq.1_Intron	NM_001040202	NP_001035292	Q6TCH7	PAQR3_HUMAN	progestin and adipoQ receptor family member III	84	Helical; (Potential).					Golgi membrane|integral to membrane	receptor activity				0						CCCAGGGTGAAGAAGAGAAAG	0.368													G	79856373	G	G	79856373	3	3	209	1	0	0	0	0	1	0	0	0	11436	72	3	4	705	4	PAQR3	4	79856373	Missense_Mutation	SNP	A	TCGA-28-5207-01A-01D-1486-08	66252856	79856373	111297903	21	14676											
APC	324	broad.mit.edu	37	chr5	112175591	112175591	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctggacaaaccatgccaccaAgcagaagtaaaacacctcca	6	14	0	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr5:112175591A>G	uc010jby.2	+	16	4680	c.4300A>G	c.(4300-4302)AGC>GGC	p.S1434G	APC_uc011cvt.1_Missense_Mutation_p.S1416G|APC_uc003kpz.3_Missense_Mutation_p.S1434G|APC_uc003kpy.3_Missense_Mutation_p.S1434G|APC_uc010jbz.2_Missense_Mutation_p.S1151G|APC_uc010jca.2_Missense_Mutation_p.S734G	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1434	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.S1434I(1)|p.P1424fs*19(1)|p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CATGCCACCAAGCAGAAGTAA	0.483		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			G	112175591	G	G	112175591	3	3	209	1	0	0	0	0	1	0	0	0	763	72	3	4	4358	4	APC	5	112175591	Missense_Mutation	SNP	A	TCGA-28-5207-01A-01D-1486-08		112175591	68739669	22	14677											
PCDHGA8	9708	broad.mit.edu	37	chr5	140773167	140773167	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccccaggcacgcggctgcttActgtaacagccagcgacccg	11	17	0	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr5:140773167A>G	uc003lkd.1	+	1	1685	c.787A>G	c.(787-789)ACT>GCT	p.T263A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.T263A	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	263	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGCTGCTTACTGTAACAGC	0.473													G	140773167	G	G	140773167	3	3	209	1	0	0	0	0	1	0	0	0	11560	391	14	4	789	4	PCDHGA8	5	140773167	Missense_Mutation	SNP	A	TCGA-28-5207-01A-01D-1486-08	28597576	140773167	40142093	23	14678											
SPRY4	81848	broad.mit.edu	37	chr5	141694230	141694230	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgcttgtccagctcgggtggGaccgccgggcccttgaggtc	16	13	0	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr5:141694230G>A	uc003lml.2	-	2	703	c.444C>T	c.(442-444)GTC>GTT	p.V148V	SPRY4_uc010jgi.1_Silent_p.V171V	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	148					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCGGGTGGGACCGCCGGGC	0.652									Testicular_Cancer_Familial_Clustering_of				A	141694230	A	A	141694230	2	1	209	1	0	0	0	0	0	0	0	1	15107	1161	41	3		3	SPRY4	5	141694230	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	921063	141694230	39221030	24	14679											
HLA-DOA	3111	broad.mit.edu	37	chr6	32974898	32974898	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcccatgatgatgaggacGgtgcccacgaggaagcccac	14	12	0	3			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr6:32974898G>A	uc003ocr.2	-	4	784	c.708C>T	c.(706-708)ACC>ACT	p.T236T	HLA-DOA_uc010juj.2_Intron|HLA-DOA_uc010jui.2_3'UTR	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	236	Helical; (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						TGATGAGGACGGTGCCCACGA	0.627													A	32974898	A	A	32974898	2	1	209	1	0	0	0	0	0	0	0	1	7200	1103	39	2		2	HLA-DOA	6	32974898	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08		32974898	138140169	25	14680											
C6orf154	221424	broad.mit.edu	37	chr6	43475289	43475291	+	In_Frame_Del	DEL	TCC	-	-													cgccagcccctcctgccactTcctcctcctcctctccctca							TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr6:43475289_43475291delTCC	uc003ovk.1	-	5	1684_1686	c.783_785delGGA	c.(781-786)GAGGAA>GAA	p.261_262EE>E	C6orf154_uc003ovj.1_In_Frame_Del_p.70_71EE>E	NM_001012974	NP_001012992	Q5JTD7	CF154_HUMAN	hypothetical protein LOC221424	261_262	Poly-Glu.										0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			TCCTGCCACTTCCTCCTCCTCCT	0.631													-	43475291	-	-	43475289	7	5	209	1	0	1	0	1	0	0	0	0	2339	1783	62	0	173	0	C6orf154	6	43475289	In_Frame_Del	DEL	TCC	TCGA-28-5207-01A-01D-1486-08	10500391	43475289	127639778	26	14681											
PLA2G7	7941	broad.mit.edu	37	chr6	46678392	46678392	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acattcttttgctctttgccGtacctaatataattattaga	4	8	2	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr6:46678392G>T	uc010jzf.2	-	8	936	c.667C>A	c.(667-669)CGG>AGG	p.R223R	PLA2G7_uc010jzg.1_Silent_p.R223R|PLA2G7_uc011dwd.1_Silent_p.R178R|PLA2G7_uc011dwe.1_Silent_p.R96R	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	223					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			GCTCTTTGCCGTACCTAATAT	0.323													T	46678392	T	T	46678392	2	4	209	1	0	0	0	0	0	0	0	1	12009	1144	40	5		5	PLA2G7	6	46678392	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	3203103	46678392	124436675	27	14682											
QKI	9444	broad.mit.edu	37	chr6	163984582	163984585	+	Frame_Shift_Del	DEL	CAGA	-	-													cctaccataatgcctttgatCagacaaatacagaccgctgt							TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr6:163984582_163984585delCAGA	uc003qui.2	+	6	1316_1319	c.765_768delCAGA	c.(763-768)ATCAGAfs	p.I255fs	QKI_uc003que.2_Frame_Shift_Del_p.I255fs|QKI_uc003quf.2_Frame_Shift_Del_p.I255fs|QKI_uc003qug.2_Frame_Shift_Del_p.I255fs|QKI_uc003quh.2_Frame_Shift_Del_p.I247fs|QKI_uc003quj.2_Frame_Shift_Del_p.I247fs	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	255_256					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		TGCCTTTGATCAGACAAATACAGA	0.554													-	163984585	-	-	163984582	7	5	209	1	0	1	0	1	0	0	0	0	12873	816	29	0	787	0	QKI	6	163984582	Frame_Shift_Del	DEL	CAGA	TCGA-28-5207-01A-01D-1486-08	117306190	163984582	7130485	28	14683											
EGFR	1956	broad.mit.edu	37	chr7	55221821	55221821	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggcaaatacagctttggtGccacctgcgtgaagaagtgt	13	8	0	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr7:55221821G>A	uc003tqk.2	+	7	1111	c.865G>A	c.(865-867)GCC>ACC	p.A289T	EGFR_uc003tqh.2_Missense_Mutation_p.A289T|EGFR_uc003tqi.2_Missense_Mutation_p.A289T|EGFR_uc003tqj.2_Missense_Mutation_p.A289T|EGFR_uc010kzg.1_Missense_Mutation_p.A244T|EGFR_uc011kco.1_Missense_Mutation_p.A236T|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTTTGGTGCCACCTGCGT	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55221821	A	A	55221821	3	1	209	1	0	0	0	0	1	0	0	0	4967	1319	46	3	891	3	EGFR	7	55221821	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08		55221821	103916842	29	14684											
HYAL4	23553	broad.mit.edu	37	chr7	123508443	123508443	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcttgtctaaaacctgctcGacttccaatttatcaaagga	5	11	3	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr7:123508443G>A	uc003vlc.2	+	3	754	c.116G>A	c.(115-117)CGA>CAA	p.R39Q	HYAL4_uc011knz.1_Missense_Mutation_p.R39Q	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	39	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						AAACCTGCTCGACTTCCAATT	0.323													A	123508443	A	A	123508443	3	1	209	1	0	0	0	0	1	0	0	0	7466	1058	37	2	118	2	HYAL4	7	123508443	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08	68286622	123508443	35630220	30	14685											
PLXNA4	91584	broad.mit.edu	37	chr7	131859666	131859666	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctcatggatgtccgtctgCagctcggcaaaggctggcac	13	12	2	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr7:131859666C>T	uc003vra.3	-	21	4117	c.3888G>A	c.(3886-3888)CTG>CTA	p.L1296L		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1296	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGTCCGTCTGCAGCTCGGCAA	0.562													T	131859666	T	T	131859666	2	4	209	1	0	0	0	0	0	0	0	1	12122	697	25	3		3	PLXNA4	7	131859666	Silent	SNP	C	TCGA-28-5207-01A-01D-1486-08	8351223	131859666	27278997	31	14686											
CHRM2	1129	broad.mit.edu	37	chr7	136700324	136700324	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttctccaagtctggtacaaGgaaggatagtgaagccaaac	10	8	2	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr7:136700324G>C	uc003vtf.1	+	4	1335	c.712G>C	c.(712-714)GGA>CGA	p.G238R	CHRM2_uc003vtg.1_Missense_Mutation_p.G238R|CHRM2_uc003vtj.1_Missense_Mutation_p.G238R|CHRM2_uc003vtk.1_Missense_Mutation_p.G238R|CHRM2_uc003vtl.1_Missense_Mutation_p.G238R|CHRM2_uc003vtm.1_Missense_Mutation_p.G238R|CHRM2_uc003vti.1_Missense_Mutation_p.G238R|CHRM2_uc003vto.1_Missense_Mutation_p.G238R|CHRM2_uc003vtn.1_Missense_Mutation_p.G238R|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	238	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	TCTGGTACAAGGAAGGATAGT	0.507													C	136700324	C	C	136700324	3	2	209	1	0	0	0	0	1	0	0	0	3377	1001	35	5	714	5	CHRM2	7	136700324	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08	4840658	136700324	22438339	32	14687											
TNKS	8658	broad.mit.edu	37	chr8	9620738	9620738	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccagaagataaagaatatcAgtcagtggaagaagaggtaa	11	4	2	5			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr8:9620738A>G	uc003wss.2	+	22	3361	c.3356A>G	c.(3355-3357)CAG>CGG	p.Q1119R	TNKS_uc011kww.1_Missense_Mutation_p.Q882R	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1119	PARP catalytic.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		AAAGAATATCAGTCAGTGGAA	0.358													G	9620738	G	G	9620738	3	3	209	1	0	0	0	0	1	0	0	0	16316	188	7	4	3442	4	TNKS	8	9620738	Missense_Mutation	SNP	A	TCGA-28-5207-01A-01D-1486-08		9620738	136743284	33	14688											
GSDMC	56169	broad.mit.edu	37	chr8	130762682	130762682	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtggagcccctcaccatgtTcatcaggtcctgtagagccc	10	14	3	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr8:130762682T>C	uc003ysr.2	-	11	1960	c.1078A>G	c.(1078-1080)AAC>GAC	p.N360D		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	360						mitochondrion				ovary(2)|skin(1)	3						CTCACCATGTTCATCAGGTCC	0.468													C	130762682	C	C	130762682	3	2	209	1	0	0	0	0	1	0	0	0	6818	1783	62	4	464	4	GSDMC	8	130762682	Missense_Mutation	SNP	T	TCGA-28-5207-01A-01D-1486-08	121141944	130762682	15601340	34	14689											
PYCRL	65263	broad.mit.edu	37	chr8	144690265	144690265	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggttcctgtctgttggtgcActggccagtatgtgctgagc	14	9	1	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr8:144690265A>G	uc003yyy.2	-	2	169	c.159T>C	c.(157-159)AGT>AGC	p.S53S	PYCRL_uc011lkm.1_Silent_p.S53S|PYCRL_uc011lkn.1_RNA	NM_023078	NP_075566	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	41					proline biosynthetic process		pyrroline-5-carboxylate reductase activity				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CTGTTGGTGCACTGGCCAGTA	0.532													G	144690265	G	G	144690265	2	3	209	1	0	0	0	0	0	0	0	1	12857	156	6	4		4	PYCRL	8	144690265	Silent	SNP	A	TCGA-28-5207-01A-01D-1486-08	13927583	144690265	1673757	35	14690											
MPDZ	8777	broad.mit.edu	37	chr9	13107002	13107002	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgacagtgccttttgtccGtttaaggatggcaacagctt	11	8	0	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr9:13107002G>A	uc010mhy.2	-	45	6139	c.6088C>T	c.(6088-6090)CGG>TGG	p.R2030W	MPDZ_uc003zkx.3_Missense_Mutation_p.R254W|MPDZ_uc003zky.3_Missense_Mutation_p.R593W|MPDZ_uc010mib.2_Missense_Mutation_p.R764W|MPDZ_uc010mhx.2_Missense_Mutation_p.R881W|MPDZ_uc011lmm.1_Missense_Mutation_p.R918W|MPDZ_uc003zkz.3_Missense_Mutation_p.R752W|MPDZ_uc010mhz.2_Missense_Mutation_p.R2026W|MPDZ_uc011lmn.1_Missense_Mutation_p.R1997W|MPDZ_uc003zlb.3_Missense_Mutation_p.R2030W	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	2059	PDZ 13.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CCTTTTGTCCGTTTAAGGATG	0.483													A	13107002	A	A	13107002	3	1	209	1	0	0	0	0	1	0	0	0	9722	1144	40	1	41	1	MPDZ	9	13107002	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08		13107002	128106429	36	14691											
ZCCHC6	79670	broad.mit.edu	37	chr9	88967843	88967843	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctgatctttgtggctgtcaTtcatccaagcgggttgactg	11	9	4	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr9:88967843T>C	uc004aoq.2	-	2	487	c.272A>G	c.(271-273)AAT>AGT	p.N91S	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.N91S|ZCCHC6_uc004aou.2_Missense_Mutation_p.N91S|ZCCHC6_uc004aov.2_Missense_Mutation_p.N91S|ZCCHC6_uc004aow.2_Missense_Mutation_p.N91S|ZCCHC6_uc010mqf.1_Missense_Mutation_p.N91S	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	91					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						GTGGCTGTCATTCATCCAAGC	0.438													C	88967843	C	C	88967843	3	2	209	1	0	0	0	0	1	0	0	0	17589	1493	52	4	4319	4	ZCCHC6	9	88967843	Missense_Mutation	SNP	T	TCGA-28-5207-01A-01D-1486-08	75860841	88967843	52245588	37	14692											
NEBL	10529	broad.mit.edu	37	chr10	21124444	21124444	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	atcacgcaccctactaacctCactcgctatctctgcagcct	4	18	3	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr10:21124444C>A	uc001iqi.2	-	14	1844	c.1447G>T	c.(1447-1449)GAG>TAG	p.E483*	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	483	Nebulin 13.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CTACTAACCTCACTCGCTATC	0.423													A	21124444	A	A	21124444	4	1	209	1	0	0	0	0	0	1	0	0	10303	835	29	5	1657	5	NEBL	10	21124444	Nonsense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08		21124444	114410303	38	14693											
COL17A1	1308	broad.mit.edu	37	chr10	105798222	105798222	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccagagctgctgatagagccCggaggcccagggggcccagg	17	13	0	3			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr10:105798222C>A	uc001kxr.2	-	45	3181	c.3012G>T	c.(3010-3012)CCG>CCT	p.P1004P		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1004	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TGATAGAGCCCGGAGGCCCAG	0.607													A	105798222	A	A	105798222	2	1	209	1	0	0	0	0	0	0	0	1	3674	639	23	5		5	COL17A1	10	105798222	Silent	SNP	C	TCGA-28-5207-01A-01D-1486-08	84673778	105798222	29736525	39	14694											
CTSF	8722	broad.mit.edu	37	chr11	66334786	66334786	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattgaagccatcttcacagGcaagtcctggataggcagac	11	10	2	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr11:66334786G>A	uc001oip.2	-	4	628	c.538C>T	c.(538-540)CCT>TCT	p.P180S		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	180					proteolysis	lysosome	cysteine-type endopeptidase activity				0						ATCTTCACAGGCAAGTCCTGG	0.522													A	66334786	A	A	66334786	3	1	209	1	0	0	0	0	1	0	0	0	4034	1203	42	3	956	3	CTSF	11	66334786	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08		66334786	68671730	40	14695											
SLCO2B1	11309	broad.mit.edu	37	chr11	74904384	74904384	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcctgcccaagttcctggaGcgccagttttccatcacagc	8	15	1	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr11:74904384G>A	uc001owb.2	+	9	1584	c.1197G>A	c.(1195-1197)GAG>GAA	p.E399E	SLCO2B1_uc010rrq.1_Silent_p.E144E|SLCO2B1_uc010rrr.1_Silent_p.E255E|SLCO2B1_uc010rrs.1_Silent_p.E283E|SLCO2B1_uc001owc.2_Silent_p.E172E|SLCO2B1_uc001owd.2_Silent_p.E377E	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	399	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	AGTTCCTGGAGCGCCAGTTTT	0.612													A	74904384	A	A	74904384	2	1	209	1	0	0	0	0	0	0	0	1	14727	962	34	3		3	SLCO2B1	11	74904384	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	8569598	74904384	60102132	41	14696											
C11orf63	79864	broad.mit.edu	37	chr11	122756720	122756720	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaagcctcacgcaagagattAtgtgccattctgagtttgat	9	8	2	3			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr11:122756720A>G	uc001pym.2	+	2	460	c.163A>G	c.(163-165)ATG>GTG	p.M55V	C11orf63_uc001pyl.1_Missense_Mutation_p.M55V	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	55										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GCAAGAGATTATGTGCCATTC	0.488													G	122756720	G	G	122756720	3	3	209	1	0	0	0	0	1	0	0	0	1654	449	16	4	165	4	C11orf63	11	122756720	Missense_Mutation	SNP	A	TCGA-28-5207-01A-01D-1486-08	47852336	122756720	12249796	42	14697											
ATP5B	506	broad.mit.edu	37	chr12	57033894	57033894	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccagctcagcaatggcacgcGacagtacagtggtagcatcc	11	13	1	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr12:57033894G>A	uc001slr.2	-	8	1262	c.1157C>T	c.(1156-1158)TCG>TTG	p.S386L		NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	386					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						AATGGCACGCGACAGTACAGT	0.512													A	57033894	A	A	57033894	3	1	209	1	0	0	0	0	1	0	0	0	1148	1059	37	2	444	2	ATP5B	12	57033894	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08		57033894	76818001	43	14698											
MARS	4141	broad.mit.edu	37	chr12	57883052	57883053	+	Frame_Shift_Ins	INS	-	T	T													gctctctctctgggcagataINStttttttttgttatctggct					rs11540808		TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr12:57883052_57883053insT	uc001sog.2	+	3	226_227	c.203_204insT	c.(202-204)TATfs	p.Y68fs	ARHGAP9_uc001sod.2_5'Flank|ARHGAP9_uc001soe.1_5'Flank|MARS_uc001sof.1_RNA|MARS_uc010srp.1_Intron|MARS_uc010srq.1_5'UTR	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	68					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CTGGGCAGATATTTTTTTTTGT	0.485													T	57883053	T	T	57883052	7	5	209	1	0	1	1	0	0	0	0	0	9316	449	16	0	213	0	MARS	12	57883052	Frame_Shift_Ins	INS	-	TCGA-28-5207-01A-01D-1486-08	849158	57883052	75968843	44	14699											
FLT1	2321	broad.mit.edu	37	chr13	28877307	28877307	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aggcttcgtgtcaaactctaGatgggtggggtggagtacag	16	6	2	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr13:28877307G>C	uc001usb.3	-	30	4299	c.4014C>G	c.(4012-4014)ATC>ATG	p.I1338M	FLT1_uc010aap.2_Missense_Mutation_p.I343M|FLT1_uc010aaq.2_Missense_Mutation_p.I463M|FLT1_uc001usa.3_Missense_Mutation_p.I556M	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1338	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TCAAACTCTAGATGGGTGGGG	0.488													C	28877307	C	C	28877307	3	2	209	1	0	0	0	0	1	0	0	0	5941	932	33	5	6	5	FLT1	13	28877307	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08		28877307	86292571	45	14700											
NALCN	259232	broad.mit.edu	37	chr13	101742235	101742235	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aataacatctctcacttccaCccagcctttcaaggagagaa	5	13	3	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr13:101742235C>T	uc001vox.1	-	29	3541	c.3352G>A	c.(3352-3354)GTG>ATG	p.V1118M		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1118	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTCACTTCCACCCAGCCTTTC	0.453													T	101742235	T	T	101742235	3	4	209	1	0	0	0	0	1	0	0	0	10148	507	18	3	1928	3	NALCN	13	101742235	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	72864928	101742235	13427643	46	14701											
HERC1	8925	broad.mit.edu	37	chr15	63970125	63970125	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcccagcagcgtggcatggCgcccagtttgcttgtgaaca	12	13	0	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr15:63970125C>T	uc002amp.2	-	37	7137	c.6989G>A	c.(6988-6990)CGC>CAC	p.R2330H		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2330					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CGTGGCATGGCGCCCAGTTTG	0.527													T	63970125	T	T	63970125	3	4	209	1	0	0	0	0	1	0	0	0	7057	768	27	1	7764	1	HERC1	15	63970125	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08		63970125	38561267	47	14702											
A2BP1	54715	broad.mit.edu	37	chr16	7629900	7629900	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccttcaggttccgggatcCggacctcagacaaatgtttg	10	13	2	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr16:7629900C>T	uc002cys.2	+	6	1380	c.392C>T	c.(391-393)CCG>CTG	p.P131L	A2BP1_uc010buf.1_Missense_Mutation_p.P131L|A2BP1_uc002cyr.1_Missense_Mutation_p.P130L|A2BP1_uc002cyt.2_Missense_Mutation_p.P131L|A2BP1_uc010uxz.1_Missense_Mutation_p.P174L|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Missense_Mutation_p.P131L|A2BP1_uc010uyb.1_Missense_Mutation_p.P131L|A2BP1_uc002cyw.2_Missense_Mutation_p.P151L|A2BP1_uc002cyy.2_Missense_Mutation_p.P151L|A2BP1_uc002cyx.2_Missense_Mutation_p.P151L|A2BP1_uc010uyc.1_Missense_Mutation_p.P151L	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	131	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TTCCGGGATCCGGACCTCAGA	0.537													T	7629900	T	T	7629900	3	4	209	1	0	0	0	0	1	0	0	0	3	652	23	2	493	2	A2BP1	16	7629900	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08		7629900	82724853	48	14703											
LCAT	3931	broad.mit.edu	37	chr16	67976842	67976842	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggatctggacaccaggggCgttggacacgagcccagagc	16	12	1	1	rs28940886		TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr16:67976842C>T	uc002euy.1	-	3	360	c.349G>A	c.(349-351)GCC>ACC	p.A117T		NM_000229	NP_000220	P04180	LCAT_HUMAN	lecithin-cholesterol acyltransferase precursor	117					cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|reverse cholesterol transport|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein A-I binding|phosphatidylcholine-sterol O-acyltransferase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00418)|Epithelial(162;0.0183)|all cancers(182;0.12)		ACACCAGGGGCGTTGGACACG	0.642													T	67976842	T	T	67976842	3	4	209	1	0	0	0	0	1	0	0	0	8658	768	27	1	989	1	LCAT	16	67976842	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	60346942	67976842	22377911	49	14704											
USP6	9098	broad.mit.edu	37	chr17	5037198	5037198	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagatcatgaaggagagggGcaagaggtcatctgaacaca	13	7	3	5			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr17:5037198G>A	uc002gau.1	+	15	2631	c.401G>A	c.(400-402)GGC>GAC	p.G134D	USP6_uc002gav.1_Missense_Mutation_p.G134D|USP6_uc010ckz.1_5'UTR|USP6_uc002gaw.2_Missense_Mutation_p.G195D|uc002gay.1_5'Flank|uc002gba.2_5'Flank|uc002gbb.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	134	Rab-GAP TBC.				protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						AAGGAGAGGGGCAAGAGGTCA	0.552			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								A	5037198	A	A	5037198	3	1	209	1	0	0	0	0	1	0	0	0	17083	1203	42	3	423	3	USP6	17	5037198	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08		5037198	76158012	50	14705											
TP53	7157	broad.mit.edu	37	chr17	7577141	7577141	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gcacctcaaagctgttccgtCccagtagattaccactactc	6	15	1	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr17:7577141C>A	uc002gim.2	-	8	991	c.797G>T	c.(796-798)GGA>GTA	p.G266V	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G266V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G134V|TP53_uc010cng.1_Missense_Mutation_p.G134V|TP53_uc002gii.1_Missense_Mutation_p.G134V|TP53_uc010cnh.1_Missense_Mutation_p.G266V|TP53_uc010cni.1_Missense_Mutation_p.G266V|TP53_uc002gij.2_Missense_Mutation_p.G266V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	266	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(45)|p.G266R(42)|p.G266V(32)|p.G266*(12)|p.0?(7)|p.G266fs*79(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266G(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.G266fs*9(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTGTTCCGTCCCAGTAGATT	0.517		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577141	A	A	7577141	3	1	209	1	0	0	0	0	1	0	0	0	16378	855	30	5	489	5	TP53	17	7577141	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	2539943	7577141	73618069	51	14706											
KRT40	125115	broad.mit.edu	37	chr17	39135111	39135111	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgatctcaccctccagccGggccttcacgtccaggagca	10	16	2	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr17:39135111G>A	uc010cxh.1	-	8	1302	c.1141C>T	c.(1141-1143)CGG>TGG	p.R381W	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	381	Rod.|Coil 2.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				CCCTCCAGCCGGGCCTTCACG	0.582													A	39135111	A	A	39135111	3	1	209	1	0	0	0	0	1	0	0	0	8478	1115	39	2	162	2	KRT40	17	39135111	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08	31557970	39135111	42060099	52	14707											
SP6	80320	broad.mit.edu	37	chr17	45925367	45925367	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctgaagcgcccccgggtgGccaggtgaggtcagcgcgcc	17	15	1	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr17:45925367G>A	uc002img.1	-	2	761	c.429C>T	c.(427-429)GGC>GGT	p.G143G	SP6_uc002imh.1_Silent_p.G143G	NM_199262	NP_954871	Q3SY56	SP6_HUMAN	Sp6 transcription factor	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCCCCGGGTGGCCAGGTGAGG	0.706													A	45925367	A	A	45925367	2	1	209	1	0	0	0	0	0	0	0	1	14968	1190	42	3		3	SP6	17	45925367	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	6790256	45925367	35269843	53	14708											
OTOP2	92736	broad.mit.edu	37	chr17	72926423	72926423	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctgcctctgcagcacggcCgtctgccagatcttccagca	9	17	3	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr17:72926423C>T	uc010wrp.1	+	7	782	c.693C>T	c.(691-693)GCC>GCT	p.A231A		NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	231						integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					GCAGCACGGCCGTCTGCCAGA	0.562													T	72926423	T	T	72926423	2	4	209	1	0	0	0	0	0	0	0	1	11306	639	23	2		2	OTOP2	17	72926423	Silent	SNP	C	TCGA-28-5207-01A-01D-1486-08	27001056	72926423	8268787	54	14709											
PRPSAP1	5635	broad.mit.edu	37	chr17	74326154	74326154	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catcaggagacttagctacaAtgactgcatttctgtaattt	7	8	2	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr17:74326154A>G	uc010wta.1	-	6	1051	c.605T>C	c.(604-606)ATT>ACT	p.I202T	PRPSAP1_uc010wtb.1_Missense_Mutation_p.I99T	NM_002766	NP_002757	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate	173					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			ovary(1)	1						CTTAGCTACAATGACTGCATT	0.393													G	74326154	G	G	74326154	3	3	209	1	0	0	0	0	1	0	0	0	12581	101	4	4	572	4	PRPSAP1	17	74326154	Missense_Mutation	SNP	A	TCGA-28-5207-01A-01D-1486-08	1399731	74326154	6869056	55	14710											
COLEC12	81035	broad.mit.edu	37	chr18	335090	335090	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acgctctccggggggaccagCtggtccaattgggcctctct	13	14	2	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr18:335090C>G	uc002kkm.2	-	6	1683	c.1468G>C	c.(1468-1470)GCT>CCT	p.A490P		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	490	Collagen-like 2.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GGGGGACCAGCTGGTCCAATT	0.677													G	335090	G	G	335090	3	3	209	1	0	0	0	0	1	0	0	0	3712	797	28	5	780	5	COLEC12	18	335090	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08		335090	77742158	56	14711											
ICAM1	3383	broad.mit.edu	37	chr19	10394791	10394791	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accgtggtctgttccctggaCgggctgttcccagtctcgga	13	13	2	0	rs143689328	byFrequency	TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr19:10394791C>T	uc002mnq.2	+	4	1039	c.720C>T	c.(718-720)GAC>GAT	p.D240D	ICAM1_uc010xle.1_Intron|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	240	Ig-like C2-type 3.|Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	GTTCCCTGGACGGGCTGTTCC	0.637													T	10394791	T	T	10394791	2	4	209	1	0	0	0	0	0	0	0	1	7479	535	19	1		1	ICAM1	19	10394791	Silent	SNP	C	TCGA-28-5207-01A-01D-1486-08		10394791	48734192	57	14712											
SMARCA4	6597	broad.mit.edu	37	chr19	11132404	11132404	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactctggggcccgcagatcCgttggaagtacatgattgtg	13	10	1	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr19:11132404C>T	uc002mqf.3	+	19	2904	c.2620C>T	c.(2620-2622)CGT>TGT	p.R874C	SMARCA4_uc010dxp.2_Missense_Mutation_p.R874C|SMARCA4_uc010dxo.2_Missense_Mutation_p.R874C|SMARCA4_uc002mqg.1_Missense_Mutation_p.R874C|SMARCA4_uc010dxq.2_Missense_Mutation_p.R874C|SMARCA4_uc010dxr.2_Missense_Mutation_p.R874C|SMARCA4_uc002mqj.3_Missense_Mutation_p.R874C|SMARCA4_uc010dxs.2_Missense_Mutation_p.R874C|SMARCA4_uc010dxt.1_Missense_Mutation_p.R94C|SMARCA4_uc002mqh.3_5'UTR|SMARCA4_uc002mqi.1_Missense_Mutation_p.R77C	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	874	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CCCGCAGATCCGTTGGAAGTA	0.632			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				T	11132404	T	T	11132404	3	4	209	1	0	0	0	0	1	0	0	0	14770	652	23	2	2690	2	SMARCA4	19	11132404	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	737613	11132404	47996579	58	14713											
ZNF625	90589	broad.mit.edu	37	chr19	12256527	12256527	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtgagttctttcatgtattCgaaggctaccagaatgacta	9	7	2	3			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr19:12256527C>T	uc002mth.2	-	4	856	c.506G>A	c.(505-507)CGA>CAA	p.R169Q	ZNF20_uc002mtg.1_Intron|ZNF625_uc010dyn.1_RNA|ZNF625_uc010dyo.1_Missense_Mutation_p.R203Q	NM_145233	NP_660276	Q96I27	ZN625_HUMAN	zinc finger protein 625	169	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCATGTATTCGAAGGCTACC	0.408													T	12256527	T	T	12256527	3	4	209	1	0	0	0	0	1	0	0	0	18046	884	31	2	418	2	ZNF625	19	12256527	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	1124123	12256527	46872456	59	14714											
B3GNT3	10331	broad.mit.edu	37	chr19	17922705	17922705	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcttccccattgatgatgTcttcctgggtatgtgtctgg	10	10	3	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr19:17922705T>C	uc002nhk.1	+	3	978	c.893T>C	c.(892-894)GTC>GCC	p.V298A	B3GNT3_uc002nhl.1_Missense_Mutation_p.V298A|B3GNT3_uc010ebd.1_Missense_Mutation_p.V298A|B3GNT3_uc010ebe.1_Missense_Mutation_p.V298A	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	298	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						ATTGATGATGTCTTCCTGGGT	0.632													C	17922705	C	C	17922705	3	2	209	1	0	0	0	0	1	0	0	0	1258	1667	58	4	899	4	B3GNT3	19	17922705	Missense_Mutation	SNP	T	TCGA-28-5207-01A-01D-1486-08	5666178	17922705	41206278	60	14715											
JAK3	3718	broad.mit.edu	37	chr19	17943330	17943330	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccgggagctggctcacccGggccatagctgacaccacga	12	15	1	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr19:17943330G>A	uc002nhn.3	-	19	2778	c.2678C>T	c.(2677-2679)CCG>CTG	p.P893L	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Missense_Mutation_p.P893L	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	893	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						TGGCTCACCCGGGCCATAGCT	0.542		2	Mis		acute megakaryocytic leukemia|								A	17943330	A	A	17943330	3	1	209	1	0	0	0	0	1	0	0	0	7939	1116	39	2	720	2	JAK3	19	17943330	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08	20625	17943330	41185653	61	14716											
ZNF792	126375	broad.mit.edu	37	chr19	35449589	35449589	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcactcatgggcacttctGcccgtatgaaccctcttatg	8	14	3	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr19:35449589G>A	uc002nxh.1	-	4	1557	c.1170C>T	c.(1168-1170)GGC>GGT	p.G390G		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GGGCACTTCTGCCCGTATGAA	0.468													A	35449589	A	A	35449589	2	1	209	1	0	0	0	0	0	0	0	1	18161	1306	46	3		3	ZNF792	19	35449589	Silent	SNP	G	TCGA-28-5207-01A-01D-1486-08	17506259	35449589	23679394	62	14717											
FCGBP	8857	broad.mit.edu	37	chr19	40360855	40360855	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccaccccaagcccctactcaCcggcaagtatcggccattat	6	18	1	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr19:40360855C>A	uc002omp.3	-	33	15560	c.15552_splice	c.e33+1	p.P5184_splice		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor							extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCCCTACTCACCGGCAAGTAT	0.577													A	40360855	A	A	40360855	5	1	209	1	0	0	0	0	0	0	1	0	5778	521	18	5	680	5	FCGBP	19	40360855	Splice_Site	SNP	C	TCGA-28-5207-01A-01D-1486-08	4911266	40360855	18768128	63	14718											
C19orf48	84798	broad.mit.edu	37	chr19	51301380	51301380	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggagcagctcccccaggattCtggcctgcttcacccctgga	11	16	2	0			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr19:51301380C>A	uc002ptf.2	-	5	1248	c.326G>T	c.(325-327)AGA>ATA	p.R109I	C19orf48_uc002pte.2_RNA|C19orf48_uc002ptg.2_Missense_Mutation_p.R109I	NM_199249	NP_954857	Q6RUI8	CS048_HUMAN	multidrug resistance-related protein	109										ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00531)|GBM - Glioblastoma multiforme(134;0.0145)		CCCCAGGATTCTGGCCTGCTT	0.627													A	51301380	A	A	51301380	3	1	209	1	0	0	0	0	1	0	0	0	1931	913	32	5	31	5	C19orf48	19	51301380	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08	10940525	51301380	7827603	64	14719											
SIGLEC8	27181	broad.mit.edu	37	chr19	51960480	51960480	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	agtcatggtcaagttccaagGagggtctgggacagaaagac	14	7	3	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr19:51960480G>C	uc002pwt.2	-	3	806	c.739C>G	c.(739-741)CCT>GCT	p.P247A	SIGLEC8_uc010yda.1_Intron|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Missense_Mutation_p.P154A	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	247	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AAGTTCCAAGGAGGGTCTGGG	0.557													C	51960480	C	C	51960480	3	2	209	1	0	0	0	0	1	0	0	0	14314	1174	41	5	780	5	SIGLEC8	19	51960480	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08	659100	51960480	7168503	65	14720											
ADRBK2	157	broad.mit.edu	37	chr22	26117315	26117315	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaaattaaagacaaaaaatGcattttgttcagaataaaag	5	4	2	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr22:26117315G>A	uc003abx.3	+	20	2003	c.1856G>A	c.(1855-1857)TGC>TAC	p.C619Y	ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	619	PH.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	GACAAAAAATGCATTTTGTTC	0.274													A	26117315	A	A	26117315	3	1	209	1	0	0	0	0	1	0	0	0	344	1319	46	3	1934	3	ADRBK2	22	26117315	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08		26117315	25187251	66	14721											
DDX17	10521	broad.mit.edu	37	chr22	38883964	38883964	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gattggcctcttccagcactTtgataagctctctggcctgt	9	12	2	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chr22:38883964T>C	uc003avy.3	-	12	1707	c.1604A>G	c.(1603-1605)AAA>AGA	p.K535R	DDX17_uc003avw.3_5'UTR|DDX17_uc010gxp.2_5'UTR|DDX17_uc003avx.3_Missense_Mutation_p.K535R	NM_001098504	NP_001091974	Q92841	DDX17_HUMAN	DEAD box polypeptide 17 isoform 3	456	Helicase C-terminal.				RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)					TTCCAGCACTTTGATAAGCTC	0.547													C	38883964	C	C	38883964	3	2	209	1	0	0	0	0	1	0	0	0	4344	1841	64	4	599	4	DDX17	22	38883964	Missense_Mutation	SNP	T	TCGA-28-5207-01A-01D-1486-08	12766649	38883964	12420602	67	14722											
PHF8	23133	broad.mit.edu	37	chrX	54037681	54037681	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctcaaagagagtcagattggCatttgttgggcggatcaggt	14	6	3	2			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chrX:54037681C>G	uc004dsu.2	-	8	1001	c.928G>C	c.(928-930)GCC>CCC	p.A310P	PHF8_uc004dst.2_Missense_Mutation_p.A274P|PHF8_uc004dsv.2_Missense_Mutation_p.A140P|PHF8_uc004dsw.2_Missense_Mutation_p.A274P|PHF8_uc004dsx.2_Missense_Mutation_p.A38P|PHF8_uc004dsy.2_Missense_Mutation_p.A274P	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	310	JmjC.				brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						GTCAGATTGGCATTTGTTGGG	0.448													G	54037681	G	G	54037681	3	3	209	1	0	0	0	0	1	0	0	0	11840	710	25	5	2484	5	PHF8	23	54037681	Missense_Mutation	SNP	C	TCGA-28-5207-01A-01D-1486-08		54037681	101232879	68	14723											
MAGEE1	57692	broad.mit.edu	37	chrX	75649443	75649443	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ctgtgccgcccaccgcctctGatggatcggacacctccgtg	11	17	1	1			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chrX:75649443G>C	uc004ecm.1	+	1	1327	c.1120G>C	c.(1120-1122)GAT>CAT	p.D374H		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	374	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CACCGCCTCTGATGGATCGGA	0.677													C	75649443	C	C	75649443	3	2	209	1	0	0	0	0	1	0	0	0	9185	1290	45	5	1122	5	MAGEE1	23	75649443	Missense_Mutation	SNP	G	TCGA-28-5207-01A-01D-1486-08	21611762	75649443	79621117	69	14724											
RPA4	29935	broad.mit.edu	37	chrX	96139742	96139742	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agagccttgaggtattgaaaAttcatgtcctagaggacatg	11	6	1	4			TCGA-28-5207-01A-01D-1486-08	TCGA-28-5207-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2d795a16-bdc3-44f0-8c01-6eeec0e1a0b1	63c46f25-e503-4b36-b770-3aca56209084	g.chrX:96139742A>G	uc004efv.3	+	1	731	c.433A>G	c.(433-435)ATT>GTT	p.I145V	DIAPH2_uc004eft.3_Intron|DIAPH2_uc004efu.3_Intron|DIAPH2_uc004efs.2_Intron	NM_013347	NP_037479	Q13156	RFA4_HUMAN	replication protein A4, 34kDa	145					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding				0						GGTATTGAAAATTCATGTCCT	0.453								Other_identified_genes_with_known_or_suspected_DNA_repair_function					G	96139742	G	G	96139742	3	3	209	1	0	0	0	0	1	0	0	0	13539	101	4	4	435	4	RPA4	23	96139742	Missense_Mutation	SNP	A	TCGA-28-5207-01A-01D-1486-08	20490299	96139742	59130818	70	14725											
TMEM61	199964	broad.mit.edu	37	chr1	55457654	55457654	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctgctcagcacccagcccGcctggcctccacccagctat	7	22	1	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr1:55457654G>A	uc001cyd.2	+	3	785	c.511G>A	c.(511-513)GCC>ACC	p.A171T		NM_182532	NP_872338	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	171						integral to membrane					0						CACCCAGCCCGCCTGGCCTCC	0.642													A	55457654	A	A	55457654	3	1	210	1	0	0	0	0	1	0	0	0	16185	1087	38	1	521	1	TMEM61	1	55457654	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08		55457654	193792967	1	14726											
TTF2	8458	broad.mit.edu	37	chr1	117638845	117638845	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagcatggactgacttatgCcaccatcgatggctctgtca	10	11	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr1:117638845C>T	uc001egy.2	+	20	3130	c.3110C>T	c.(3109-3111)GCC>GTC	p.A1037V		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	1037	Helicase C-terminal.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		CTGACTTATGCCACCATCGAT	0.458													T	117638845	T	T	117638845	3	4	210	1	0	0	0	0	1	0	0	0	16716	739	26	3	3188	3	TTF2	1	117638845	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	62181191	117638845	131611776	2	14727											
PI4KB	5298	broad.mit.edu	37	chr1	151271347	151271347	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacaactttgcacaaaattgCgctgtgcactgaggaatgcc	9	11	0	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr1:151271347C>T	uc001ext.2	-	9	2367	c.1952G>A	c.(1951-1953)CGC>CAC	p.R651H	PI4KB_uc001exr.2_Missense_Mutation_p.R663H|PI4KB_uc001exs.2_Missense_Mutation_p.R636H|PI4KB_uc001exu.2_Missense_Mutation_p.R636H|PI4KB_uc010pcw.1_Missense_Mutation_p.R319H	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	651	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CACAAAATTGCGCTGTGCACT	0.502													T	151271347	T	T	151271347	3	4	210	1	0	0	0	0	1	0	0	0	11874	768	27	1	514	1	PI4KB	1	151271347	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	33632502	151271347	97979274	3	14728											
HRNR	388697	broad.mit.edu	37	chr1	152188049	152188049	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actgtcctgatgcagaaccaTgttgcccatgggtagaggaa	12	9	0	3			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr1:152188049T>G	uc001ezt.1	-	3	6132	c.6056A>C	c.(6055-6057)CAT>CCT	p.H2019P		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2019	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCAGAACCATGTTGCCCATG	0.552													G	152188049	G	G	152188049	3	3	210	1	0	0	0	0	1	0	0	0	7359	1464	51	5	2500	5	HRNR	1	152188049	Missense_Mutation	SNP	T	TCGA-28-5208-01A-01D-1486-08	916702	152188049	97062572	4	14729											
LCE5A	254910	broad.mit.edu	37	chr1	152484251	152484251	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgccagtccctccgacgcCgacctcagagttccagctgc	9	20	1	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr1:152484251C>T	uc001ezy.2	+	2	417	c.241C>T	c.(241-243)CGA>TGA	p.R81*	CRCT1_uc001ezz.2_5'Flank	NM_178438	NP_848525	Q5TCM9	LCE5A_HUMAN	late cornified envelope 5A	81	Cys-rich.				keratinization					ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCCGACGCCGACCTCAGAG	0.677													T	152484251	T	T	152484251	4	4	210	1	0	0	0	0	0	1	0	0	8675	644	23	2	243	2	LCE5A	1	152484251	Nonsense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	296202	152484251	96766370	5	14730											
ITLN1	55600	broad.mit.edu	37	chr1	160851913	160851913	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgtgcacgctggccaccaggGtccagccgccacccccagag	12	19	0	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr1:160851913G>T	uc001fxc.2	-	4	355	c.239C>A	c.(238-240)ACC>AAC	p.T80N		NM_017625	NP_060095	Q8WWA0	ITLN1_HUMAN	intelectin precursor	80	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)	7	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GGCCACCAGGGTCCAGCCGCC	0.592													T	160851913	T	T	160851913	3	4	210	1	0	0	0	0	1	0	0	0	7910	1261	44	5	722	5	ITLN1	1	160851913	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	8367662	160851913	88398708	6	14731											
C1orf125	126859	broad.mit.edu	37	chr1	179354443	179354443	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gatatttcatgaacttattcGacaagtcagtgtggactgtg	10	6	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr1:179354443G>A	uc001gmo.2	+	9	939	c.812G>A	c.(811-813)CGA>CAA	p.R271Q	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Missense_Mutation_p.R59Q|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.R271Q	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	271											0						GAACTTATTCGACAAGTCAGT	0.358													A	179354443	A	A	179354443	3	1	210	1	0	0	0	0	1	0	0	0	1993	1058	37	2	842	2	C1orf125	1	179354443	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	18502530	179354443	69896178	7	14732											
WNT9A	7483	broad.mit.edu	37	chr1	228112065	228112065	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtgcgtgcgtcaggccagccGaggagatggcatagaggaag	18	8	1	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr1:228112065G>A	uc001hri.2	-	3	477	c.389C>T	c.(388-390)TCG>TTG	p.S130L		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	130					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				CAGGCCAGCCGAGGAGATGGC	0.662													A	228112065	A	A	228112065	3	1	210	1	0	0	0	0	1	0	0	0	17395	1059	37	2	716	2	WNT9A	1	228112065	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	48757622	228112065	21138556	8	14733											
NLRP3	114548	broad.mit.edu	37	chr1	247587155	247587155	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtctttgccgtagattaccGtaagaagtacagaaagtacg	10	7	1	3	rs138946894	byFrequency	TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr1:247587155G>A	uc001icr.2	+	5	548	c.410G>A	c.(409-411)CGT>CAT	p.R137H	NLRP3_uc001ics.2_Missense_Mutation_p.R137H|NLRP3_uc001icu.2_Missense_Mutation_p.R137H|NLRP3_uc001icw.2_Missense_Mutation_p.R137H|NLRP3_uc001icv.2_Missense_Mutation_p.R137H|NLRP3_uc010pyw.1_Missense_Mutation_p.R135H|NLRP3_uc001ict.1_Missense_Mutation_p.R135H	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	137					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GTAGATTACCGTAAGAAGTAC	0.507													A	247587155	A	A	247587155	3	1	210	1	0	0	0	0	1	0	0	0	10478	1145	40	1	420	1	NLRP3	1	247587155	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	19475090	247587155	1663466	9	14734											
SNTG2	54221	broad.mit.edu	37	chr2	1168837	1168837	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctctcccctctttgacagcGgtttgcatctgaacggaaac	8	14	3	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr2:1168837G>A	uc002qwq.2	+	8	687	c.559G>A	c.(559-561)GGT>AGT	p.G187S	SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	187					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CTTTGACAGCGGTTTGCATCT	0.468													A	1168837	A	A	1168837	3	1	210	1	0	0	0	0	1	0	0	0	14875	1116	39	2	589	2	SNTG2	2	1168837	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08		1168837	242030536	10	14735											
ABCG5	64240	broad.mit.edu	37	chr2	44051252	44051252	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttctcaccaagtttcttgtcActctcctgaaaacaaacaac	3	13	4	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr2:44051252A>G	uc002rtn.2	-	9	1264	c.1124T>C	c.(1123-1125)GTG>GCG	p.V375A	ABCG5_uc002rtm.2_5'UTR|ABCG5_uc002rto.2_Missense_Mutation_p.V204A|ABCG5_uc002rtp.2_5'UTR	NM_022436	NP_071881	Q9H222	ABCG5_HUMAN	ATP-binding cassette sub-family G member 5	375	Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GTTTCTTGTCACTCTCCTGAA	0.433													G	44051252	G	G	44051252	3	3	210	1	0	0	0	0	1	0	0	0	71	159	6	4	851	4	ABCG5	2	44051252	Missense_Mutation	SNP	A	TCGA-28-5208-01A-01D-1486-08	42882415	44051252	199148121	11	14736											
KLRAQ1	129285	broad.mit.edu	37	chr2	48692078	48692078	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attatttttcttctgtagaaTatagtcagtacaacgctctg	6	7	4	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr2:48692078T>G	uc002rwm.2	+	8	882	c.697T>G	c.(697-699)TAT>GAT	p.Y233D	KLRAQ1_uc002rwi.1_Missense_Mutation_p.Y233D|KLRAQ1_uc002rwj.2_Missense_Mutation_p.Y233D|KLRAQ1_uc002rwl.2_Missense_Mutation_p.Y187D|KLRAQ1_uc002rwk.2_Missense_Mutation_p.Y233D|KLRAQ1_uc010yok.1_Missense_Mutation_p.Y233D	NM_001135629	NP_001129101	Q6ZMI0	KLRAQ_HUMAN	KLRAQ motif containing 1 isoform 1	233										ovary(1)	1						TTCTGTAGAATATAGTCAGTA	0.318													G	48692078	G	G	48692078	3	3	210	1	0	0	0	0	1	0	0	0	8413	1406	49	5	727	5	KLRAQ1	2	48692078	Missense_Mutation	SNP	T	TCGA-28-5208-01A-01D-1486-08	4640826	48692078	194507295	12	14737											
APLF	200558	broad.mit.edu	37	chr2	68729870	68729870	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tttaatttgttagatacacaCaaatccatgtttttaccagt	4	7	0	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr2:68729870C>G	uc002sep.2	+	3	349	c.176C>G	c.(175-177)ACA>AGA	p.T59R	APLF_uc010fdf.2_Missense_Mutation_p.T35R	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	59	FHA-like.				double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						TAGATACACACAAATCCATGT	0.254													G	68729870	G	G	68729870	3	3	210	1	0	0	0	0	1	0	0	0	776	478	17	5	186	5	APLF	2	68729870	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	20037792	68729870	174469503	13	14738											
ALPPL2	251	broad.mit.edu	37	chr2	233274393	233274393	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggcgcacctggttcacggCgtgcaggagcagaccttcat	13	13	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr2:233274393C>T	uc002vss.3	+	11	1463	c.1410C>T	c.(1408-1410)GGC>GGT	p.G470G		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	470					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	TGGTTCACGGCGTGCAGGAGC	0.716													T	233274393	T	T	233274393	2	4	210	1	0	0	0	0	0	0	0	1	549	755	27	1		1	ALPPL2	2	233274393	Silent	SNP	C	TCGA-28-5208-01A-01D-1486-08	164544523	233274393	9924980	14	14739											
SETD2	29072	broad.mit.edu	37	chr3	47098909	47098909	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcttgctcaaacaacttcCggcgttcctctgtagaaagt	7	13	3	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr3:47098909C>T	uc003cqs.2	-	15	6418	c.6365G>A	c.(6364-6366)CGG>CAG	p.R2122Q	SETD2_uc003cqv.2_Missense_Mutation_p.R2189Q|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2122	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AAACAACTTCCGGCGTTCCTC	0.423			N|F|S|Mis		clear cell renal carcinoma								T	47098909	T	T	47098909	3	4	210	1	0	0	0	0	1	0	0	0	14131	652	23	2	1357	2	SETD2	3	47098909	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08		47098909	150923521	15	14740											
ABHD14A	25864	broad.mit.edu	37	chr3	52014464	52014464	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagaggcagggcgggcagcGctgctggagcgggcgctgcg	21	11	0	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr3:52014464G>A	uc003dco.2	+	4	563	c.453G>A	c.(451-453)GCG>GCA	p.A151A	ABHD14B_uc003dcn.2_Intron|ACY1_uc011bea.1_Intron	NM_015407	NP_056222	Q9BUJ0	ABHEA_HUMAN	abhydrolase domain containing 14A	151						cytoplasm|integral to membrane	hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GGCGGGCAGCGCTGCTGGAGC	0.652													A	52014464	A	A	52014464	2	1	210	1	0	0	0	0	0	0	0	1	79	1074	38	1		1	ABHD14A	3	52014464	Silent	SNP	G	TCGA-28-5208-01A-01D-1486-08	4915555	52014464	146007966	16	14741											
CACNA2D3	55799	broad.mit.edu	37	chr3	55107854	55107854	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcccagaagatcagaaggCgcccagaatcttgtcatggc	12	11	3	4			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr3:55107854C>T	uc003dhf.2	+	37	3199	c.3151C>T	c.(3151-3153)CGC>TGC	p.R1051C		NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	1051	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GATCAGAAGGCGCCCAGAATC	0.448													T	55107854	T	T	55107854	3	4	210	1	0	0	0	0	1	0	0	0	2550	768	27	1	3297	1	CACNA2D3	3	55107854	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	3093390	55107854	142914576	17	14742											
SENP7	57337	broad.mit.edu	37	chr3	101136587	101136587	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtagggtctttctgaattttCgtcctaaatccgtccatagg	9	9	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr3:101136587C>T	uc003dut.2	-	5	443	c.332G>A	c.(331-333)CGA>CAA	p.R111Q	SENP7_uc003duu.2_Missense_Mutation_p.R111Q|SENP7_uc003duv.2_Missense_Mutation_p.R78Q|SENP7_uc003duw.2_Intron|SENP7_uc003dux.2_Intron	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	111					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						TCTGAATTTTCGTCCTAAATC	0.378													T	101136587	T	T	101136587	3	4	210	1	0	0	0	0	1	0	0	0	14051	884	31	2	2900	2	SENP7	3	101136587	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	46028733	101136587	96885843	18	14743											
ANKRD56	345079	broad.mit.edu	37	chr4	77817817	77817817	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	actctcctggtccacaaagtCatccagatcttggagggaca	9	12	3	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr4:77817817C>T	uc003hki.2	-	1	1186	c.1186G>A	c.(1186-1188)GAC>AAC	p.D396N		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	396											0						TCCACAAAGTCATCCAGATCT	0.572													T	77817817	T	T	77817817	3	4	210	1	0	0	0	0	1	0	0	0	682	826	29	3	1199	3	ANKRD56	4	77817817	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08		77817817	113336459	19	14744											
MMRN1	22915	broad.mit.edu	37	chr4	90857233	90857233	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gagatataactttgttttgcAagtcgccaagacccttgcag	9	9	0	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr4:90857233A>C	uc003hst.2	+	6	2473	c.2402A>C	c.(2401-2403)CAA>CCA	p.Q801P	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.Q543P	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	801					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TTTGTTTTGCAAGTCGCCAAG	0.378													C	90857233	C	C	90857233	3	2	210	1	0	0	0	0	1	0	0	0	9670	130	5	5	2424	5	MMRN1	4	90857233	Missense_Mutation	SNP	A	TCGA-28-5208-01A-01D-1486-08	13039416	90857233	100297043	20	14745											
PCDHA1	56147	broad.mit.edu	37	chr5	140167729	140167729	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccggcagcaggcggcgcGcgcatcccgttccgcgtggg	17	16	0	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr5:140167729G>A	uc003lhb.2	+	1	1854	c.1854G>A	c.(1852-1854)GCG>GCA	p.A618A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Silent_p.A618A	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	618	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGCGGCGCGCGCATCCCGT	0.667													A	140167729	A	A	140167729	2	1	210	1	0	0	0	0	0	0	0	1	11519	1074	38	1		1	PCDHA1	5	140167729	Silent	SNP	G	TCGA-28-5208-01A-01D-1486-08		140167729	40747531	21	14746											
PCDHB12	56124	broad.mit.edu	37	chr5	140590288	140590288	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccagaacgcctggctgtcGtaccagctgctcaaggccac	12	15	1	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr5:140590288G>A	uc003liz.2	+	1	1998	c.1809G>A	c.(1807-1809)TCG>TCA	p.S603S	PCDHB12_uc011dak.1_Silent_p.S266S	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	603	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGGCTGTCGTACCAGCTGC	0.721													A	140590288	A	A	140590288	2	1	210	1	0	0	0	0	0	0	0	1	11537	1132	40	1		1	PCDHB12	5	140590288	Silent	SNP	G	TCGA-28-5208-01A-01D-1486-08	422559	140590288	40324972	22	14747											
PCDHGA4	56111	broad.mit.edu	37	chr5	140736435	140736435	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctttgtgctggaccagaaCgacaatgtccctgagatcct	9	12	1	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr5:140736435C>T	uc003ljq.1	+	1	1668	c.1668C>T	c.(1666-1668)AAC>AAT	p.N556N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.N556N	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	556	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACCAGAACGACAATGTCC	0.577													T	140736435	T	T	140736435	2	4	210	1	0	0	0	0	0	0	0	1	11556	535	19	1		1	PCDHGA4	5	140736435	Silent	SNP	C	TCGA-28-5208-01A-01D-1486-08	146147	140736435	40178825	23	14748											
NOTCH4	4855	broad.mit.edu	37	chr6	32172007	32172007	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcagggctggtccagacactCgtccacgtctccctcacagc	10	17	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr6:32172007C>T	uc003obb.2	-	19	3164	c.3025G>A	c.(3025-3027)GAG>AAG	p.E1009K	NOTCH4_uc003oba.2_5'Flank|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1009	Extracellular (Potential).|EGF-like 26.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TCCAGACACTCGTCCACGTCT	0.612													T	32172007	T	T	32172007	3	4	210	1	0	0	0	0	1	0	0	0	10551	893	31	2	3034	2	NOTCH4	6	32172007	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08		32172007	138943060	24	14749											
QKI	9444	broad.mit.edu	37	chr6	163899821	163899821	+	Frame_Shift_Del	DEL	G	-	-													ttttttctcagtttaattttGttgggagaatccttggacct							TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr6:163899821delG	uc003qui.2	+	3	846	c.295delG	c.(295-297)GTTfs	p.V99fs	QKI_uc003que.2_Frame_Shift_Del_p.V99fs|QKI_uc003quf.2_Frame_Shift_Del_p.V99fs|QKI_uc003qug.2_Frame_Shift_Del_p.V99fs|QKI_uc003quh.2_Frame_Shift_Del_p.V99fs|QKI_uc003quj.2_Frame_Shift_Del_p.V99fs	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	99	KH.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		GTTTAATTTTGTTGGGAGAAT	0.358													-	163899821	-	-	163899821	7	5	210	1	0	1	0	1	0	0	0	0	12873	1377	48	0	305	0	QKI	6	163899821	Frame_Shift_Del	DEL	G	TCGA-28-5208-01A-01D-1486-08	131727814	163899821	7215246	25	14750											
ANLN	54443	broad.mit.edu	37	chr7	36459856	36459856	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caaaaccaggaaaattccaaAgaactcgtgtccctcgagct	7	12	0	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr7:36459856A>G	uc003tff.2	+	11	2152	c.1948A>G	c.(1948-1950)AGA>GGA	p.R650G	ANLN_uc011kaz.1_Missense_Mutation_p.R562G|ANLN_uc003tfg.2_Missense_Mutation_p.R613G|ANLN_uc010kxe.2_Missense_Mutation_p.R612G	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	650	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						AAAATTCCAAAGAACTCGTGT	0.433													G	36459856	G	G	36459856	3	3	210	1	0	0	0	0	1	0	0	0	694	64	3	4	1990	4	ANLN	7	36459856	Missense_Mutation	SNP	A	TCGA-28-5208-01A-01D-1486-08		36459856	122678807	26	14751											
CACNA2D1	781	broad.mit.edu	37	chr7	81799924	81799924	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctccgcttccaatgccaggCgctgaaaaacaaacaataaa	6	12	1	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr7:81799924C>T	uc003uhr.1	-	4	552	c.296G>A	c.(295-297)CGC>CAC	p.R99H		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	99	Extracellular (Potential).			R -> S (in Ref. 1; AAA51903).		voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CAATGCCAGGCGCTGAAAAAC	0.348													T	81799924	T	T	81799924	3	4	210	1	0	0	0	0	1	0	0	0	2548	782	27	1	3123	1	CACNA2D1	7	81799924	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	45340068	81799924	77338739	27	14752											
PCLO	27445	broad.mit.edu	37	chr7	82784341	82784341	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggctaggctgttgagctgagGgttttgctgagccaggctgt	17	7	0	3			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr7:82784341G>T	uc003uhx.2	-	2	1905	c.1616C>A	c.(1615-1617)CCC>CAC	p.P539H	PCLO_uc003uhv.2_Missense_Mutation_p.P539H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	485	Gln-rich.|Pro-rich.|10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTGAGCTGAGGGTTTTGCTGA	0.547													T	82784341	T	T	82784341	3	4	210	1	0	0	0	0	1	0	0	0	11583	1232	43	5	13925	5	PCLO	7	82784341	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	984417	82784341	76354322	28	14753											
SAMD9L	219285	broad.mit.edu	37	chr7	92763758	92763758	+	Nonsense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaatgtggttctagaggtttAtatgtctcgcttttcaggtc	10	6	3	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr7:92763758A>C	uc003umh.1	-	5	2743	c.1527T>G	c.(1525-1527)TAT>TAG	p.Y509*	SAMD9L_uc003umj.1_Nonsense_Mutation_p.Y509*|SAMD9L_uc003umi.1_Nonsense_Mutation_p.Y509*|SAMD9L_uc010lfb.1_Nonsense_Mutation_p.Y509*|SAMD9L_uc003umk.1_Nonsense_Mutation_p.Y509*|SAMD9L_uc010lfc.1_Nonsense_Mutation_p.Y509*|SAMD9L_uc010lfd.1_Nonsense_Mutation_p.Y509*|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	509										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CTAGAGGTTTATATGTCTCGC	0.378													C	92763758	C	C	92763758	4	2	210	1	0	0	0	0	0	1	0	0	13827	456	16	5	3231	5	SAMD9L	7	92763758	Nonsense_Mutation	SNP	A	TCGA-28-5208-01A-01D-1486-08	9979417	92763758	66374905	29	14754											
TPD52L3	89882	broad.mit.edu	37	chr9	6328761	6328761	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tactagcagccaaagagagaCgctgtggggaactcaagagg	14	8	1	3			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr9:6328761C>T	uc003zjw.2	+	1	387	c.166C>T	c.(166-168)CGC>TGC	p.R56C	TPD52L3_uc003zjv.2_Missense_Mutation_p.R56C|TPD52L3_uc003zjx.1_Missense_Mutation_p.R56C	NM_033516	NP_277051	Q96J77	TPD55_HUMAN	protein kinase NYD-SP25 isoform 1	56	Potential.						protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		CAAAGAGAGACGCTGTGGGGA	0.512													T	6328761	T	T	6328761	3	4	210	1	0	0	0	0	1	0	0	0	16397	536	19	1	168	1	TPD52L3	9	6328761	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08		6328761	134884670	30	14755											
TMEM215	401498	broad.mit.edu	37	chr9	32784670	32784670	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagacgtccagatacctggaCggctactgcccctcgggcag	13	14	0	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr9:32784670C>T	uc003zri.3	+	2	854	c.489C>T	c.(487-489)GAC>GAT	p.D163D		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	163						integral to membrane					0						GATACCTGGACGGCTACTGCC	0.602													T	32784670	T	T	32784670	2	4	210	1	0	0	0	0	0	0	0	1	16135	535	19	1		1	TMEM215	9	32784670	Silent	SNP	C	TCGA-28-5208-01A-01D-1486-08	26455909	32784670	108428761	31	14756											
TRPM6	140803	broad.mit.edu	37	chr9	77423011	77423011	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttttctagtgtagttgctgCgatatgctctaccaatgagg	11	7	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr9:77423011C>T	uc004ajl.1	-	14	1815	c.1577G>A	c.(1576-1578)CGC>CAC	p.R526H	TRPM6_uc004ajk.1_Missense_Mutation_p.R521H|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.R526H|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	526	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTAGTTGCTGCGATATGCTCT	0.388													T	77423011	T	T	77423011	3	4	210	1	0	0	0	0	1	0	0	0	16587	768	27	1	4595	1	TRPM6	9	77423011	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	44638341	77423011	63790420	32	14757											
FGD3	89846	broad.mit.edu	37	chr9	95792189	95792189	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactatcctctaagaccagaCgtgacaaggagaagcagagc	10	10	1	5			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr9:95792189C>T	uc004asw.2	+	15	2219	c.1591C>T	c.(1591-1593)CGT>TGT	p.R531C	FGD3_uc004asx.2_Missense_Mutation_p.R531C|FGD3_uc004asz.2_Missense_Mutation_p.R531C|FGD3_uc011luc.1_Missense_Mutation_p.R134C	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	531					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						TAAGACCAGACGTGACAAGGA	0.537													T	95792189	T	T	95792189	3	4	210	1	0	0	0	0	1	0	0	0	5834	536	19	1	1641	1	FGD3	9	95792189	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	18369178	95792189	45421242	33	14758											
ODF3	113746	broad.mit.edu	37	chr11	197577	197577	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaggcttcatgaagcacacGcccaccaagctgcgtgcacc	9	16	1	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr11:197577G>A	uc001lob.2	+	3	420	c.126G>A	c.(124-126)ACG>ACA	p.T42T	ODF3_uc010qvk.1_Silent_p.T42T|ODF3_uc001loc.2_Silent_p.T42T	NM_053280	NP_444510	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3	42					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm		p.T42T(1)		ovary(1)	1		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		TGAAGCACACGCCCACCAAGC	0.652													A	197577	A	A	197577	2	1	210	1	0	0	0	0	0	0	0	1	10829	1074	38	1		1	ODF3	11	197577	Silent	SNP	G	TCGA-28-5208-01A-01D-1486-08		197577	134808939	34	14759											
APBB1	322	broad.mit.edu	37	chr11	6423823	6423823	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tacttccccccagcccccagAcatggggtcatgcaggttgt	10	15	1	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr11:6423823A>G	uc001mdb.1	-	7	1337	c.1237T>C	c.(1237-1239)TCT>CCT	p.S413P	APBB1_uc001mcz.1_Missense_Mutation_p.S34P|APBB1_uc001mdd.3_Missense_Mutation_p.S193P|APBB1_uc001mda.2_Intron|APBB1_uc001mdc.1_Missense_Mutation_p.S413P|APBB1_uc010rab.1_5'Flank|APBB1_uc010rac.1_5'Flank|APBB1_uc010rad.1_Missense_Mutation_p.S34P|APBB1_uc010rae.1_Missense_Mutation_p.S178P|APBB1_uc010raf.1_Missense_Mutation_p.S154P|APBB1_uc009yfa.2_Missense_Mutation_p.S154P|APBB1_uc009yey.2_Missense_Mutation_p.S154P|APBB1_uc010rag.1_Missense_Mutation_p.S154P|APBB1_uc009yfb.2_Missense_Mutation_p.S154P|APBB1_uc001mde.2_Missense_Mutation_p.S154P|APBB1_uc010rah.1_Missense_Mutation_p.S154P	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	413	PID 1.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CAGCCCCCAGACATGGGGTCA	0.582													G	6423823	G	G	6423823	3	3	210	1	0	0	0	0	1	0	0	0	759	275	10	4	927	4	APBB1	11	6423823	Missense_Mutation	SNP	A	TCGA-28-5208-01A-01D-1486-08	6226246	6423823	128582693	35	14760											
OR5D16	390144	broad.mit.edu	37	chr11	55606713	55606713	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatgttccctgacactcgcGtgctctgctttaaagttatc	8	12	1	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr11:55606713G>A	uc010rio.1	+	1	486	c.486G>A	c.(484-486)GCG>GCA	p.A162A		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	162	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TGACACTCGCGTGCTCTGCTT	0.453													A	55606713	A	A	55606713	2	1	210	1	0	0	0	0	0	0	0	1	11156	1132	40	1		1	OR5D16	11	55606713	Silent	SNP	G	TCGA-28-5208-01A-01D-1486-08	49182890	55606713	79399803	36	14761											
OR8H3	390152	broad.mit.edu	37	chr11	55890211	55890211	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctctcctcaatggcctatgaTcgctatgcagcgatctgcag	9	13	3	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr11:55890211T>G	uc001nii.1	+	1	363	c.363T>G	c.(361-363)GAT>GAG	p.D121E		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TGGCCTATGATCGCTATGCAG	0.468													G	55890211	G	G	55890211	3	3	210	1	0	0	0	0	1	0	0	0	11239	1432	50	5	365	5	OR8H3	11	55890211	Missense_Mutation	SNP	T	TCGA-28-5208-01A-01D-1486-08	283498	55890211	79116305	37	14762											
TCN1	6947	broad.mit.edu	37	chr11	59630133	59630133	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atatattaagttttcctcagCgttacgacatactcccaaag	5	10	1	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr11:59630133C>T	uc001noj.2	-	3	420	c.322G>A	c.(322-324)GCT>ACT	p.A108T		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	108					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTTTCCTCAGCGTTACGACAT	0.358													T	59630133	T	T	59630133	3	4	210	1	0	0	0	0	1	0	0	0	15703	768	27	1	1007	1	TCN1	11	59630133	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	3739922	59630133	75376383	38	14763											
AHNAK	79026	broad.mit.edu	37	chr11	62284308	62284308	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctagaagaggaggacagtcGggacttcttagaggccaggg	17	7	1	3			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr11:62284308G>A	uc001ntl.2	-	5	17881	c.17581C>T	c.(17581-17583)CGA>TGA	p.R5861*	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5861					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GAGGACAGTCGGGACTTCTTA	0.522													A	62284308	A	A	62284308	4	1	210	1	0	0	0	0	0	1	0	0	414	1124	39	2	211	2	AHNAK	11	62284308	Nonsense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	2654175	62284308	72722208	39	14764											
TECTA	7007	broad.mit.edu	37	chr11	120983846	120983846	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcaccctcttcaattattaCgaaatcaactggaccacggg	6	12	4	0	rs148364865	byFrequency	TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr11:120983846C>T	uc010rzo.1	+	4	552	c.552C>T	c.(550-552)TAC>TAT	p.Y184Y		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	184	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCAATTATTACGAAATCAACT	0.567											OREG0021430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	120983846	T	T	120983846	2	4	210	1	0	0	0	0	0	0	0	1	15744	547	19	1		1	TECTA	11	120983846	Silent	SNP	C	TCGA-28-5208-01A-01D-1486-08	58699538	120983846	14022670	40	14765											
OR4D5	219875	broad.mit.edu	37	chr11	123811110	123811110	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acgtctatacaaggccttttCggacattccccatggacaag	8	12	1	0	rs141929562		TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr11:123811110C>T	uc001pzk.1	+	1	787	c.787C>T	c.(787-789)CGG>TGG	p.R263W		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AAGGCCTTTTCGGACATTCCC	0.512													T	123811110	T	T	123811110	3	4	210	1	0	0	0	0	1	0	0	0	11057	875	31	2	789	2	OR4D5	11	123811110	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	2827264	123811110	11195406	41	14766											
ATN1	1822	broad.mit.edu	37	chr12	7047759	7047759	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgcccccctacctgggtcCtgacactccagccttgcgca	9	18	0	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr12:7047759C>T	uc001qrw.1	+	7	2870	c.2633C>T	c.(2632-2634)CCT>CTT	p.P878L	ATN1_uc001qrx.1_Missense_Mutation_p.P878L	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	878					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TACCTGGGTCCTGACACTCCA	0.632											OREG0021641	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	7047759	T	T	7047759	3	4	210	1	0	0	0	0	1	0	0	0	1111	681	24	3	2655	3	ATN1	12	7047759	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08		7047759	126804136	42	14767											
SLC26A10	65012	broad.mit.edu	37	chr12	58014190	58014190	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctacacttctttcttccccGtcctcatctacagcttgcta	3	16	5	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr12:58014190G>A	uc001spe.2	+	1	498	c.187G>A	c.(187-189)GTC>ATC	p.V63I	uc001spc.2_5'Flank|SLC26A10_uc001spf.2_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	63	Helical; (Potential).					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					TTTCTTCCCCGTCCTCATCTA	0.537													A	58014190	A	A	58014190	3	1	210	1	0	0	0	0	1	0	0	0	14515	1145	40	1	189	1	SLC26A10	12	58014190	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	50966431	58014190	75837705	43	14768											
NOS1	4842	broad.mit.edu	37	chr12	117723944	117723944	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggatcctgcccacacagcGcgaggcattccgccaggcgt	12	16	0	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr12:117723944G>A	uc001twm.1	-	6	1941	c.1255C>T	c.(1255-1257)CGC>TGC	p.R419C		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	419					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCCACACAGCGCGAGGCATTC	0.557													A	117723944	A	A	117723944	3	1	210	1	0	0	0	0	1	0	0	0	10541	1087	38	1	3145	1	NOS1	12	117723944	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	59709754	117723944	16127951	44	14769											
KDM2B	84678	broad.mit.edu	37	chr12	121890960	121890960	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatgcagctctgcttcatgCgcccggggcccccgaacttc	11	16	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr12:121890960C>T	uc001uat.2	-	13	2026	c.1922G>A	c.(1921-1923)CGC>CAC	p.R641H	KDM2B_uc001uaq.2_Missense_Mutation_p.R81H|KDM2B_uc010szy.1_Missense_Mutation_p.R81H|KDM2B_uc001uar.2_Missense_Mutation_p.R232H|KDM2B_uc001uas.2_Missense_Mutation_p.R610H|KDM2B_uc001uau.2_Missense_Mutation_p.R524H	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	641	CXXC-type.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CTGCTTCATGCGCCCGGGGCC	0.706													T	121890960	T	T	121890960	3	4	210	1	0	0	0	0	1	0	0	0	8125	768	27	1	2184	1	KDM2B	12	121890960	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	4167016	121890960	11960935	45	14770											
KBTBD6	89890	broad.mit.edu	37	chr13	41705212	41705212	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatagtctcgaattaccattAggtcaaaggataaaaaagaa	8	5	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr13:41705212A>G	uc001uxu.1	-	1	1725	c.1436T>C	c.(1435-1437)CTA>CCA	p.L479P	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.L413P|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	479	Kelch 2.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		AATTACCATTAGGTCAAAGGA	0.433													G	41705212	G	G	41705212	3	3	210	1	0	0	0	0	1	0	0	0	7997	420	15	4	592	4	KBTBD6	13	41705212	Missense_Mutation	SNP	A	TCGA-28-5208-01A-01D-1486-08		41705212	73464666	46	14771											
TSHR	7253	broad.mit.edu	37	chr14	81610025	81610025	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctcaggcacgcatgtgccatCatggttgggggctgggtttg	16	9	2	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr14:81610025C>T	uc001xvd.1	+	10	1779	c.1623C>T	c.(1621-1623)ATC>ATT	p.I541I		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	541	Helical; Name=4; (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CATGTGCCATCATGGTTGGGG	0.587			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						T	81610025	T	T	81610025	2	4	210	1	0	0	0	0	0	0	0	1	16619	816	29	3		3	TSHR	14	81610025	Silent	SNP	C	TCGA-28-5208-01A-01D-1486-08		81610025	25739515	47	14772											
ASB2	51676	broad.mit.edu	37	chr14	94404157	94404157	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggacatcgatgatgggccccGcccagcggctcacctctggg	14	15	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr14:94404157G>A	uc001ycc.1	-	7	2003	c.1514C>T	c.(1513-1515)GCG>GTG	p.A505V	ASB2_uc001ycb.1_Missense_Mutation_p.A199V|ASB2_uc001ycd.2_Missense_Mutation_p.A553V|ASB2_uc001yce.1_Missense_Mutation_p.A451V	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	505					intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		GATGGGCCCCGCCCAGCGGCT	0.597													A	94404157	A	A	94404157	3	1	210	1	0	0	0	0	1	0	0	0	1023	1087	38	1	257	1	ASB2	14	94404157	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	12794132	94404157	12945383	48	14773											
MGA	23269	broad.mit.edu	37	chr15	42058284	42058284	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtttggtagatatgggtggCagcaaatatcctcatgaagt	13	5	1	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr15:42058284C>T	uc010ucy.1	+	24	8185	c.8004C>T	c.(8002-8004)GGC>GGT	p.G2668G	MGA_uc010ucz.1_Silent_p.G2459G	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2629						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		ATATGGGTGGCAGCAAATATC	0.393													T	42058284	T	T	42058284	2	4	210	1	0	0	0	0	0	0	0	1	9540	697	25	3		3	MGA	15	42058284	Silent	SNP	C	TCGA-28-5208-01A-01D-1486-08		42058284	60473108	49	14774											
EIF3J	8669	broad.mit.edu	37	chr15	44849840	44849840	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtcttagttcgagatgtgtGtatttcatgtaagtaattct	9	4	3	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr15:44849840G>A	uc001ztv.2	+	6	690	c.563G>A	c.(562-564)TGT>TAT	p.C188Y	EIF3J_uc010ueg.1_Intron|EIF3J_uc001ztw.2_Missense_Mutation_p.C139Y	NM_003758	NP_003749	O75822	EIF3J_HUMAN	eukaryotic translation initiation factor 3,	188						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity				0		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)		CGAGATGTGTGTATTTCATGT	0.313													A	44849840	A	A	44849840	3	1	210	1	0	0	0	0	1	0	0	0	5020	1377	48	3	585	3	EIF3J	15	44849840	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	2791556	44849840	57681552	50	14775											
MORF4L1	10933	broad.mit.edu	37	chr15	79183885	79183885	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcagcctcctcggaagaaaAgggcccgggtagatcctact	11	13	1	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr15:79183885A>G	uc002bel.2	+	8	714	c.526A>G	c.(526-528)AGG>GGG	p.R176G	MORF4L1_uc010bli.1_3'UTR|MORF4L1_uc010blj.1_Missense_Mutation_p.R110G|MORF4L1_uc002bem.2_Missense_Mutation_p.R137G|MORF4L1_uc010une.1_Missense_Mutation_p.R49G	NM_206839	NP_996670	Q9UBU8	MO4L1_HUMAN	MORF-related gene 15 isoform 2	176	Sufficient for interaction with SIN3A.|Interaction with RB1-1.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding				0						TCGGAAGAAAAGGGCCCGGGT	0.448													G	79183885	G	G	79183885	3	3	210	1	0	0	0	0	1	0	0	0	9706	63	3	4	556	4	MORF4L1	15	79183885	Missense_Mutation	SNP	A	TCGA-28-5208-01A-01D-1486-08	34334045	79183885	23347507	51	14776											
GRIN2A	2903	broad.mit.edu	37	chr16	9943716	9943716	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggggcctcctccagggtgaCgatgctgagatggttgtcat	15	9	1	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr16:9943716C>T	uc002czo.3	-	5	1773	c.1225G>A	c.(1225-1227)GTC>ATC	p.V409I	GRIN2A_uc010uym.1_Missense_Mutation_p.V409I|GRIN2A_uc010uyn.1_Missense_Mutation_p.V252I|GRIN2A_uc002czr.3_Missense_Mutation_p.V409I	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	409	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCCAGGGTGACGATGCTGAGA	0.582													T	9943716	T	T	9943716	3	4	210	1	0	0	0	0	1	0	0	0	6779	536	19	1	3205	1	GRIN2A	16	9943716	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08		9943716	80411037	52	14777											
CPNE7	27132	broad.mit.edu	37	chr16	89649923	89649923	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgtgcaggggtggccacaCgcagggatggcaggtgcttg	19	9	0	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr16:89649923C>T	uc002fnp.2	+	4	699	c.569C>T	c.(568-570)ACG>ATG	p.T190M	CPNE7_uc002fnq.2_Intron	NM_014427	NP_055242	Q9UBL6	CPNE7_HUMAN	copine 7 isoform b	190					lipid metabolic process		transporter activity				0		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GGTGGCCACACGCAGGGATGG	0.522													T	89649923	T	T	89649923	3	4	210	1	0	0	0	0	1	0	0	0	3817	536	19	1	583	1	CPNE7	16	89649923	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	79706207	89649923	704830	53	14778											
NF1	4763	broad.mit.edu	37	chr17	29533378	29533378	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggagcacacccagcaataCgaatggcaccggtaagataa	11	10	0	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr17:29533378C>T	uc002hgg.2	+	12	1714	c.1381C>T	c.(1381-1383)CGA>TGA	p.R461*	NF1_uc002hge.1_Nonsense_Mutation_p.R461*|NF1_uc002hgf.1_Nonsense_Mutation_p.R461*|NF1_uc002hgh.2_Nonsense_Mutation_p.R461*|NF1_uc010csn.1_Nonsense_Mutation_p.R321*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	461					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.R461*(2)|p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CCCAGCAATACGAATGGCACC	0.383			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29533378	T	T	29533378	4	4	210	1	0	0	0	0	0	1	0	0	10356	528	19	1	1427	1	NF1	17	29533378	Nonsense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08		29533378	51661832	54	14779											
NF1	4763	broad.mit.edu	37	chr17	29552132	29552132	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaggcagatagaagttcctGtcactttctccttttttacg	8	10	2	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr17:29552132G>T	uc002hgg.2	+	17	2198	c.1865G>T	c.(1864-1866)TGT>TTT	p.C622F	NF1_uc002hgh.2_Missense_Mutation_p.C622F|NF1_uc010csn.1_Missense_Mutation_p.C482F|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	622					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGAAGTTCCTGTCACTTTCTC	0.373			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29552132	T	T	29552132	3	4	210	1	0	0	0	0	1	0	0	0	10356	1377	48	5	1992	5	NF1	17	29552132	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	18754	29552132	51643078	55	14780											
TMEM132E	124842	broad.mit.edu	37	chr17	32956104	32956104	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaccagccagtcagtcaagCggaggatcatgtggcacatt	11	11	4	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr17:32956104C>T	uc002hif.2	+	5	1277	c.949C>T	c.(949-951)CGG>TGG	p.R317W		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	317	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GTCAGTCAAGCGGAGGATCAT	0.612													T	32956104	T	T	32956104	3	4	210	1	0	0	0	0	1	0	0	0	16045	759	27	1	967	1	TMEM132E	17	32956104	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	3403972	32956104	48239106	56	14781											
C17orf46	124783	broad.mit.edu	37	chr17	43333267	43333267	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcaaagtcagactcctcGttcgagttggcttccgtgtc	9	12	3	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr17:43333267G>A	uc002iis.1	-	4	378	c.282C>T	c.(280-282)AAC>AAT	p.N94N	LOC100133991_uc010dah.2_Intron|C17orf46_uc010wjk.1_Silent_p.N73N	NM_152343	NP_689556	Q96LK8	CQ046_HUMAN	hypothetical protein LOC124783	94										large_intestine(1)|ovary(1)	2						CAGACTCCTCGTTCGAGTTGG	0.542													A	43333267	A	A	43333267	2	1	210	1	0	0	0	0	0	0	0	1	1857	1136	40	1		1	C17orf46	17	43333267	Silent	SNP	G	TCGA-28-5208-01A-01D-1486-08	10377163	43333267	37861943	57	14782											
LRRC37A3	374819	broad.mit.edu	37	chr17	62893283	62893283	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgagcctccttgactagtagCcacaatagttgccacataag	8	11	0	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr17:62893283C>G	uc002jey.2	-	3	624	c.93G>C	c.(91-93)TGG>TGC	p.W31C	LRRC37A3_uc010wqg.1_Intron|LRRC37A3_uc010wqf.1_Intron	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	31						integral to membrane					0						TGACTAGTAGCCACAATAGTT	0.622													G	62893283	G	G	62893283	3	3	210	1	0	0	0	0	1	0	0	0	8993	740	26	5	4859	5	LRRC37A3	17	62893283	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	19560016	62893283	18301927	58	14783											
ZNF532	55205	broad.mit.edu	37	chr18	56587257	56587257	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcgtccttgcagagttctGtggtggaagctttcaacaag	12	8	2	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr18:56587257G>A	uc002lho.2	+	4	2285	c.1738G>A	c.(1738-1740)GTG>ATG	p.V580M	ZNF532_uc002lhp.2_Missense_Mutation_p.V578M|ZNF532_uc010xeg.1_Missense_Mutation_p.V578M|ZNF532_uc002lhr.2_Missense_Mutation_p.V578M|ZNF532_uc002lhs.2_Missense_Mutation_p.V578M	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GCAGAGTTCTGTGGTGGAAGC	0.522													A	56587257	A	A	56587257	3	1	210	1	0	0	0	0	1	0	0	0	17969	1377	48	3	1740	3	ZNF532	18	56587257	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08		56587257	21489991	59	14784											
ZNF236	7776	broad.mit.edu	37	chr18	74680222	74680222	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaggacggggaggagctgaGccggaccctccacctggagg	18	12	0	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr18:74680222G>T	uc002lmi.2	+	31	5663	c.5465G>T	c.(5464-5466)AGC>ATC	p.S1822I	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1822					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GAGGAGCTGAGCCGGACCCTC	0.602													T	74680222	T	T	74680222	3	4	210	1	0	0	0	0	1	0	0	0	17786	971	34	5	5587	5	ZNF236	18	74680222	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	18092965	74680222	3397026	60	14785											
ACTL9	284382	broad.mit.edu	37	chr19	8808430	8808430	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggttgtagccctggaagaCgggcactgtgtaggtgaccc	15	10	0	2	rs139329295		TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr19:8808430C>T	uc002mkl.2	-	1	743	c.622G>A	c.(622-624)GTC>ATC	p.V208I		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	208						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						CCCTGGAAGACGGGCACTGTG	0.667													T	8808430	T	T	8808430	3	4	210	1	0	0	0	0	1	0	0	0	203	536	19	1	632	1	ACTL9	19	8808430	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08		8808430	50320553	61	14786											
PVR	5817	broad.mit.edu	37	chr19	45153152	45153152	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtgcccatggcccgctgcGtctccacagggggtcgcccg	14	17	1	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr19:45153152G>A	uc002ozm.2	+	3	798	c.499G>A	c.(499-501)GTC>ATC	p.V167I	PVR_uc010ejs.2_Missense_Mutation_p.V167I|PVR_uc010xxb.1_Missense_Mutation_p.V167I|PVR_uc010xxc.1_Missense_Mutation_p.V167I|PVR_uc002ozn.2_Missense_Mutation_p.V112I	NM_006505	NP_006496	P15151	PVR_HUMAN	poliovirus receptor isoform alpha	167	Extracellular (Potential).|Ig-like C2-type 1.				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		GGCCCGCTGCGTCTCCACAGG	0.617													A	45153152	A	A	45153152	3	1	210	1	0	0	0	0	1	0	0	0	12837	1145	40	1	509	1	PVR	19	45153152	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	36344722	45153152	13975831	62	14787											
NTF4	4909	broad.mit.edu	37	chr19	49564639	49564639	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctcaggcccggccagtccGgctgaggagtgtgcagacgc	16	13	1	2	rs121918427		TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr19:49564639G>A	uc002pmf.3	-	2	757	c.616C>T	c.(616-618)CGG>TGG	p.R206W	CGB7_uc010yah.1_Intron	NM_006179	NP_006170	P34130	NTF4_HUMAN	neurotrophin 5 preproprotein	206			R -> Q (in a patient with primary open- angle glaucoma; uncertain pathological significance).|R -> W (in patients with primary open- angle glaucoma and normal pressure glaucoma; uncertain pathological significance; impaired ligand-mediated TRKB signaling and reduced neurite outgrowth).		adult locomotory behavior|epidermis development|ganglion mother cell fate determination|long-term memory|sensory organ boundary specification	endoplasmic reticulum lumen|extracellular region	growth factor activity				0		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		CGGCCAGTCCGGCTGAGGAGT	0.602													A	49564639	A	A	49564639	3	1	210	1	0	0	0	0	1	0	0	0	10697	1115	39	2	20	2	NTF4	19	49564639	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	4411487	49564639	9564344	63	14788											
ZNF813	126017	broad.mit.edu	37	chr19	53994271	53994271	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgaaacctagtgtgccatcGtagatgtcacactggggaga	13	9	1	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr19:53994271G>A	uc002qbu.2	+	4	913	c.785G>A	c.(784-786)CGT>CAT	p.R262H	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	262	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		GTGTGCCATCGTAGATGTCAC	0.413													A	53994271	A	A	53994271	3	1	210	1	0	0	0	0	1	0	0	0	18172	1145	40	1	795	1	ZNF813	19	53994271	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	4429632	53994271	5134712	64	14789											
ZNF335	63925	broad.mit.edu	37	chr20	44587938	44587938	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagaagaaggggcgacggcGggaggggggctcctcagggt	22	7	1	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr20:44587938G>A	uc002xqw.2	-	15	2278	c.2155C>T	c.(2155-2157)CGC>TGC	p.R719C	ZNF335_uc010zxk.1_Missense_Mutation_p.R564C	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	719					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				GGGCGACGGCGGGAGGGGGGC	0.657													A	44587938	A	A	44587938	3	1	210	1	0	0	0	0	1	0	0	0	17849	1116	39	2	1929	2	ZNF335	20	44587938	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08		44587938	18437582	65	14790											
UCKL1	54963	broad.mit.edu	37	chr20	62571758	62571758	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgcgcactgccatcatggcCgccgcgcccgtggacacggt	13	17	1	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr20:62571758C>T	uc010gkn.2	-	13	1426	c.1383G>A	c.(1381-1383)GCG>GCA	p.A461A	UCKL1_uc002yhj.2_Silent_p.A104A|UCKL1_uc011abm.1_Silent_p.A446A|UCKL1_uc011abn.1_RNA	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	461					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCATCATGGCCGCCGCGCCCG	0.642													T	62571758	T	T	62571758	2	4	210	1	0	0	0	0	0	0	0	1	16922	639	23	2		2	UCKL1	20	62571758	Silent	SNP	C	TCGA-28-5208-01A-01D-1486-08	17983820	62571758	453762	66	14791											
TPTE	7179	broad.mit.edu	37	chr21	10942995	10942995	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttaacagaataataagtcGtagaagtcgaagtaaatgtg	9	4	1	2	rs147014138	byFrequency	TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr21:10942995G>A	uc002yip.1	-	12	960	c.592C>T	c.(592-594)CGA>TGA	p.R198*	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Nonsense_Mutation_p.R180*|TPTE_uc002yir.1_Nonsense_Mutation_p.R160*|TPTE_uc010gkv.1_Nonsense_Mutation_p.R60*	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	198					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATAATAAGTCGTAGAAGTCGA	0.299													A	10942995	A	A	10942995	4	1	210	1	0	0	0	0	0	1	0	0	16427	1153	40	1	1115	1	TPTE	21	10942995	Nonsense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08		10942995	37186900	67	14792											
KLHL22	84861	broad.mit.edu	37	chr22	20819524	20819524	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcttccatcagcggaaaccGcactgtctcaaggagctttg	10	12	2	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr22:20819524G>A	uc002zsl.1	-	4	842	c.733C>T	c.(733-735)CGG>TGG	p.R245W	KLHL22_uc011ahr.1_Missense_Mutation_p.R102W|KLHL22_uc002zsm.1_Missense_Mutation_p.R245W	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	245					cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AGCGGAAACCGCACTGTCTCA	0.607													A	20819524	A	A	20819524	3	1	210	1	0	0	0	0	1	0	0	0	8377	1086	38	1	1187	1	KLHL22	22	20819524	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08		20819524	30485042	68	14793											
RFPL2	10739	broad.mit.edu	37	chr22	32586994	32586994	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccccactcgctgtaacttgCggtctacgaagaggaaagtc	10	12	1	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chr22:32586994C>T	uc003amg.3	-	5	1838	c.902G>A	c.(901-903)CGC>CAC	p.R301H	RFPL2_uc003ame.3_Missense_Mutation_p.R240H|RFPL2_uc003amf.3_Missense_Mutation_p.R211H|RFPL2_uc003amh.3_Missense_Mutation_p.R211H	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	301	B30.2/SPRY.						zinc ion binding			skin(1)	1						CTGTAACTTGCGGTCTACGAA	0.512													T	32586994	T	T	32586994	3	4	210	1	0	0	0	0	1	0	0	0	13254	768	27	1	238	1	RFPL2	22	32586994	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	11767470	32586994	18717572	69	14794											
TLR7	51284	broad.mit.edu	37	chrX	12906487	12906487	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacagcttagcaaaaagacaGtgtttgtgatgacagacaag	10	6	0	4			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chrX:12906487G>A	uc004cvc.2	+	3	2999	c.2860G>A	c.(2860-2862)GTG>ATG	p.V954M		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	954	TIR.|Cytoplasmic (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	CAAAAAGACAGTGTTTGTGAT	0.388													A	12906487	A	A	12906487	3	1	210	1	0	0	0	0	1	0	0	0	15953	1029	36	3	2866	3	TLR7	23	12906487	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08		12906487	142364073	70	14795											
CHRDL1	91851	broad.mit.edu	37	chrX	109922646	109922646	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttctcaatatggaagtgctgGagaatgcctagggccaagca	12	8	1	1			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chrX:109922646G>A	uc004eou.3	-	11	1513	c.1164C>T	c.(1162-1164)CTC>CTT	p.L388L	CHRDL1_uc004eov.2_Silent_p.L377L|CHRDL1_uc004eow.2_Silent_p.L386L|CHRDL1_uc010nps.2_Silent_p.L387L|CHRDL1_uc004eot.2_Silent_p.L307L|CHRDL1_uc011mss.1_Silent_p.L302L	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	380					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						GGAAGTGCTGGAGAATGCCTA	0.453													A	109922646	A	A	109922646	2	1	210	1	0	0	0	0	0	0	0	1	3373	1161	41	3		3	CHRDL1	23	109922646	Silent	SNP	G	TCGA-28-5208-01A-01D-1486-08	97016159	109922646	45347914	71	14796											
AFF2	2334	broad.mit.edu	37	chrX	148039907	148039907	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatccctgagaagaagcagcGcctggaggaggccacaacta	13	11	0	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chrX:148039907G>A	uc004fcp.2	+	12	3088	c.2609G>A	c.(2608-2610)CGC>CAC	p.R870H	AFF2_uc004fcq.2_Missense_Mutation_p.R860H|AFF2_uc004fcr.2_Missense_Mutation_p.R831H|AFF2_uc011mxb.1_Missense_Mutation_p.R835H|AFF2_uc004fcs.2_Missense_Mutation_p.R837H|AFF2_uc011mxc.1_Missense_Mutation_p.R511H	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	870					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAAGCAGCGCCTGGAGGAG	0.512													A	148039907	A	A	148039907	3	1	210	1	0	0	0	0	1	0	0	0	357	1087	38	1	2710	1	AFF2	23	148039907	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	38117261	148039907	7230653	72	14797											
L1CAM	3897	broad.mit.edu	37	chrX	153130576	153130576	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagcacgtagccggtgagcaCgccgttgtggctgagtgggg	19	9	0	2			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chrX:153130576C>T	uc004fjb.2	-	21	2947	c.2839G>A	c.(2839-2841)GTG>ATG	p.V947M	L1CAM_uc004fjc.2_Missense_Mutation_p.V947M|L1CAM_uc010nuo.2_Missense_Mutation_p.V942M	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	947	Extracellular (Potential).|Fibronectin type-III 4.		Missing (in HSAS).		axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane		p.V947M(1)		ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGGTGAGCACGCCGTTGTGG	0.716													T	153130576	T	T	153130576	3	4	210	1	0	0	0	0	1	0	0	0	8588	536	19	1	966	1	L1CAM	23	153130576	Missense_Mutation	SNP	C	TCGA-28-5208-01A-01D-1486-08	5090669	153130576	2139984	73	14798											
AVPR2	554	broad.mit.edu	37	chrX	153171843	153171843	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctggtgcagctgtgggccGcgtgggacccggaggcacct	17	13	0	0			TCGA-28-5208-01A-01D-1486-08	TCGA-28-5208-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	76209124-b3f0-4bb2-8b2c-e268abdefe2b	399d129a-791c-4786-bc04-f6dada7d0242	g.chrX:153171843G>A	uc004fjh.3	+	2	954	c.883G>A	c.(883-885)GCG>ACG	p.A295T	AVPR2_uc004fjg.3_Missense_Mutation_p.A84T|AVPR2_uc004fji.2_Missense_Mutation_p.A295T	NM_000054	NP_000045	P30518	V2R_HUMAN	arginine vasopressin receptor 2 isoform 1	295	Extracellular (Potential).				activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	GCTGTGGGCCGCGTGGGACCC	0.647													A	153171843	A	A	153171843	3	1	210	1	0	0	0	0	1	0	0	0	1233	1087	38	1	889	1	AVPR2	23	153171843	Missense_Mutation	SNP	G	TCGA-28-5208-01A-01D-1486-08	41267	153171843	2098717	74	14799											
AKR7A3	22977	broad.mit.edu	37	chr1	19611245	19611245	+	Frame_Shift_Del	DEL	G	-	-													acgggctgtttcccattcttGtcctcatacttgtacttgcc							TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr1:19611245delG	uc001bbv.1	-	5	716	c.639delC	c.(637-639)GACfs	p.D213fs		NM_012067	NP_036199	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3	213					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCATTCTTGTCCTCATACT	0.597													-	19611245	-	-	19611245	7	5	211	1	0	1	0	1	0	0	0	0	476	1368	48	0	368	0	AKR7A3	1	19611245	Frame_Shift_Del	DEL	G	TCGA-28-5209-01A-01D-1486-08		19611245	229639376	1	14800											
SLC1A7	6512	broad.mit.edu	37	chr1	53559217	53559217	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggccccgctgtcacccatgCggcccagcatgatgcctgcg	13	17	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr1:53559217C>T	uc001cuy.2	-	6	881	c.713G>A	c.(712-714)CGC>CAC	p.R238H	SLC1A7_uc001cux.2_5'Flank	NM_006671	NP_006662	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter),	238						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|large_intestine(1)	3				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	GTCACCCATGCGGCCCAGCAT	0.617													T	53559217	T	T	53559217	3	4	211	1	0	0	0	0	1	0	0	0	14437	768	27	1	993	1	SLC1A7	1	53559217	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	33947972	53559217	195691404	2	14801											
ODF2L	57489	broad.mit.edu	37	chr1	86838137	86838137	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttcattgtttcaatctgtacTtccaattcggttttttctat	4	8	4	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr1:86838137T>A	uc001dll.1	-	9	1237	c.897A>T	c.(895-897)GAA>GAT	p.E299D	ODF2L_uc001dlm.1_Missense_Mutation_p.E299D|ODF2L_uc001dln.2_Missense_Mutation_p.E299D|ODF2L_uc001dlo.2_Missense_Mutation_p.E168D|ODF2L_uc001dlp.2_Missense_Mutation_p.E299D|ODF2L_uc010osg.1_Missense_Mutation_p.E299D|ODF2L_uc001dlq.1_Missense_Mutation_p.E129D|ODF2L_uc009wcr.1_Missense_Mutation_p.E168D	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	299	Potential.					centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		CAATCTGTACTTCCAATTCGG	0.259													A	86838137	A	A	86838137	3	1	211	1	0	0	0	0	1	0	0	0	10828	1606	56	5	1229	5	ODF2L	1	86838137	Missense_Mutation	SNP	T	TCGA-28-5209-01A-01D-1486-08	33278920	86838137	162412484	3	14802											
SPAG17	200162	broad.mit.edu	37	chr1	118574428	118574428	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aacggtcactataacaggaaCcactgttggagtgagtgctg	12	8	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr1:118574428C>A	uc001ehk.2	-	25	3564	c.3496G>T	c.(3496-3498)GTT>TTT	p.V1166F		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1166						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ATAACAGGAACCACTGTTGGA	0.353													A	118574428	A	A	118574428	3	1	211	1	0	0	0	0	1	0	0	0	14979	507	18	5	3271	5	SPAG17	1	118574428	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	31736291	118574428	130676193	4	14803											
FCER1A	2205	broad.mit.edu	37	chr1	159272655	159272655	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttgcagctccagatggcGtgttagcaggtgagtcctct	12	10	1	2	rs142162478		TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr1:159272655G>A	uc001ftq.2	+	3	166	c.67G>A	c.(67-69)GTG>ATG	p.V23M		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	23						integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	TCCAGATGGCGTGTTAGCAGG	0.463													A	159272655	A	A	159272655	3	1	211	1	0	0	0	0	1	0	0	0	5774	1145	40	1	73	1	FCER1A	1	159272655	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	40698227	159272655	89977966	5	14804											
PLA2G4A	5321	broad.mit.edu	37	chr1	186863266	186863266	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccaattatgtcatggatgaaActctagggacagcaacattt	8	8	2	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr1:186863266A>T	uc001gsc.2	+	5	506	c.301A>T	c.(301-303)ACT>TCT	p.T101S	PLA2G4A_uc010pos.1_Missense_Mutation_p.T101S	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	101	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	CATGGATGAAACTCTAGGGAC	0.328													T	186863266	T	T	186863266	3	4	211	1	0	0	0	0	1	0	0	0	12001	43	2	5	315	5	PLA2G4A	1	186863266	Missense_Mutation	SNP	A	TCGA-28-5209-01A-01D-1486-08	27590611	186863266	62387355	6	14805											
MIA3	375056	broad.mit.edu	37	chr1	222833136	222833136	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaagggaagctgccaatttgAgacacaagtatgtggatttt	11	5	0	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr1:222833136A>G	uc001hnl.2	+	22	4876	c.4867A>G	c.(4867-4869)AGA>GGA	p.R1623G	MIA3_uc001hnm.2_Missense_Mutation_p.R501G	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1623	Cytoplasmic (Potential).|Potential.				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		TGCCAATTTGAGACACAAGTA	0.358													G	222833136	G	G	222833136	3	3	211	1	0	0	0	0	1	0	0	0	9565	296	11	4	4953	4	MIA3	1	222833136	Missense_Mutation	SNP	A	TCGA-28-5209-01A-01D-1486-08	35969870	222833136	26417485	7	14806											
USP39	10713	broad.mit.edu	37	chr2	85863233	85863233	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgcactcagctctgggggGcacaaagaagaaaaagaaga	12	8	3	4			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr2:85863233G>A	uc002sqe.2	+	7	1043	c.1007G>A	c.(1006-1008)GGC>GAC	p.G336D	USP39_uc002sqb.2_Missense_Mutation_p.G67D|USP39_uc010ysu.1_Missense_Mutation_p.G258D|USP39_uc010ysv.1_Missense_Mutation_p.G233D|USP39_uc010fgn.1_Missense_Mutation_p.G336D|USP39_uc002sqf.2_Missense_Mutation_p.G336D|USP39_uc002sqg.2_Missense_Mutation_p.G336D|USP39_uc010fgo.2_Missense_Mutation_p.G336D	NM_006590	NP_006581	Q53GS9	SNUT2_HUMAN	ubiquitin specific protease 39	336					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)	1						GCTCTGGGGGGCACAAAGAAG	0.348													A	85863233	A	A	85863233	3	1	211	1	0	0	0	0	1	0	0	0	17067	1203	42	3	1033	3	USP39	2	85863233	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08		85863233	157336140	8	14807											
TTN	7273	broad.mit.edu	37	chr2	179631234	179631234	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttccactacatatttgtgtcGttcttgaacttggaaattga	7	7	1	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr2:179631234G>A	uc010zfg.1	-	41	9801	c.9577C>T	c.(9577-9579)CGA>TGA	p.R3193*	TTN_uc010zfh.1_Nonsense_Mutation_p.R3147*|TTN_uc010zfi.1_Nonsense_Mutation_p.R3147*|TTN_uc010zfj.1_Nonsense_Mutation_p.R3147*|TTN_uc002umz.1_5'Flank|TTN_uc002unb.2_Nonsense_Mutation_p.R3193*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3193							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTGTGTCGTTCTTGAACT	0.423													A	179631234	A	A	179631234	4	1	211	1	0	0	0	0	0	1	0	0	16732	1153	40	1	101699	1	TTN	2	179631234	Nonsense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	93768001	179631234	63568139	9	14808											
MKRN2	23609	broad.mit.edu	37	chr3	12616291	12616291	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttcctgtctgtgcttcagAtctgcatgttgacgttcgaa	9	11	3	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr3:12616291A>G	uc003bxd.2	+	5	699	c.643A>G	c.(643-645)ATC>GTC	p.I215V	MKRN2_uc003bxe.2_Missense_Mutation_p.I213V|MKRN2_uc011aus.1_Missense_Mutation_p.I172V	NM_014160	NP_054879	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	215	Makorin-type Cys-His.					intracellular	ligase activity|nucleic acid binding|zinc ion binding				0						TGTGCTTCAGATCTGCATGTT	0.542													G	12616291	G	G	12616291	3	3	211	1	0	0	0	0	1	0	0	0	9607	347	12	4	661	4	MKRN2	3	12616291	Missense_Mutation	SNP	A	TCGA-28-5209-01A-01D-1486-08		12616291	185406139	10	14809											
MST1R	4486	broad.mit.edu	37	chr3	49940348	49940348	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcagcactgacaacgccacaAagcccggtgcgaatcccgag	11	15	0	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr3:49940348A>T	uc003cxy.3	-	1	959	c.695T>A	c.(694-696)TTT>TAT	p.F232Y	MST1R_uc011bdd.1_Missense_Mutation_p.F232Y|MST1R_uc011bde.1_Missense_Mutation_p.F232Y|MST1R_uc011bdf.1_Missense_Mutation_p.F232Y|MST1R_uc011bdg.1_Missense_Mutation_p.F232Y	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	232	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CAACGCCACAAAGCCCGGTGC	0.577													T	49940348	T	T	49940348	3	4	211	1	0	0	0	0	1	0	0	0	9891	14	1	5	3587	5	MST1R	3	49940348	Missense_Mutation	SNP	A	TCGA-28-5209-01A-01D-1486-08	37324057	49940348	148082082	11	14810											
CACNA1D	776	broad.mit.edu	37	chr3	53837549	53837549	+	Nonsense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcttgggggagcaggagtaTttcagtagtgaggaatgcta	16	4	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr3:53837549T>G	uc003dgv.3	+	44	5698	c.5535T>G	c.(5533-5535)TAT>TAG	p.Y1845*	CACNA1D_uc003dgu.3_Nonsense_Mutation_p.Y1865*|CACNA1D_uc003dgy.3_Nonsense_Mutation_p.Y1821*|CACNA1D_uc003dgw.3_Nonsense_Mutation_p.Y1512*|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1845	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	AGCAGGAGTATTTCAGTAGTG	0.597													G	53837549	G	G	53837549	4	3	211	1	0	0	0	0	0	1	0	0	2541	1500	52	5	5881	5	CACNA1D	3	53837549	Nonsense_Mutation	SNP	T	TCGA-28-5209-01A-01D-1486-08	3897201	53837549	144184881	12	14811											
ACAD11	84129	broad.mit.edu	37	chr3	132360955	132360955	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctgggctaagtccaggaattGttaaatcacggaagattcga	11	7	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr3:132360955G>C	uc003eov.3	-	4	778	c.398C>G	c.(397-399)ACA>AGA	p.T133R	ACAD11_uc003eoy.2_Missense_Mutation_p.T133R	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	133						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						TCCAGGAATTGTTAAATCACG	0.378													C	132360955	C	C	132360955	3	2	211	1	0	0	0	0	1	0	0	0	109	1377	48	5	2012	5	ACAD11	3	132360955	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	78523406	132360955	65661475	13	14812											
RNF168	165918	broad.mit.edu	37	chr3	196229875	196229876	+	Frame_Shift_Del	DEL	CG	-	-													accgagtccacgacgataccCggcggcgacagaagggacag							TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr3:196229875_196229876delCG	uc003fwq.2	-	1	707_708	c.169_170delCG	c.(169-171)CGGfs	p.R57fs	RNF168_uc010iah.2_5'UTR	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	57					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		CGACGATACCCGGCGGCGACAG	0.545													-	196229876	-	-	196229875	7	5	211	1	0	1	0	1	0	0	0	0	13459	652	23	0	1569	0	RNF168	3	196229875	Frame_Shift_Del	DEL	CG	TCGA-28-5209-01A-01D-1486-08	63868920	196229875	1792555	14	14813											
ABCG2	9429	broad.mit.edu	37	chr4	89053763	89053763	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgtgggtcccaggatggcGttgagaccaggtttcatgat	14	9	1	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr4:89053763G>A	uc003hrg.2	-	3	721	c.228C>T	c.(226-228)AAC>AAT	p.N76N	ABCG2_uc003hrh.2_Silent_p.N76N|ABCG2_uc003hrf.2_5'Flank|ABCG2_uc003hri.1_Silent_p.N76N|ABCG2_uc003hrj.1_Silent_p.N76N|ABCG2_uc003hrk.1_Silent_p.N76N	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	76	ABC transporter.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	CCAGGATGGCGTTGAGACCAG	0.393													A	89053763	A	A	89053763	2	1	211	1	0	0	0	0	0	0	0	1	69	1136	40	1		1	ABCG2	4	89053763	Silent	SNP	G	TCGA-28-5209-01A-01D-1486-08		89053763	102100513	15	14814											
UNC5C	8633	broad.mit.edu	37	chr4	96256705	96256705	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cacaatataagcttcttcagGctcaataaggaaatgtggca	8	8	3	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr4:96256705G>C	uc003htp.1	-	2	356	c.202C>G	c.(202-204)CCT>GCT	p.P68A	UNC5C_uc010ilc.1_Missense_Mutation_p.P68A|UNC5C_uc003htq.2_Missense_Mutation_p.P68A	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	68	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GCTTCTTCAGGCTCAATAAGG	0.418													C	96256705	C	C	96256705	3	2	211	1	0	0	0	0	1	0	0	0	16990	1203	42	5	2653	5	UNC5C	4	96256705	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	7202942	96256705	94897571	16	14815											
PDHA2	5161	broad.mit.edu	37	chr4	96762205	96762205	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggagtcagttatcgtacaCgagaagaaattcaggaagta	11	6	2	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr4:96762205C>T	uc003htr.3	+	1	967	c.904C>T	c.(904-906)CGA>TGA	p.R302*		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	302					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TTATCGTACACGAGAAGAAAT	0.423													T	96762205	T	T	96762205	4	4	211	1	0	0	0	0	0	1	0	0	11665	528	19	1	906	1	PDHA2	4	96762205	Nonsense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	505500	96762205	94392071	17	14816											
ADAD1	132612	broad.mit.edu	37	chr4	123317517	123317517	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atagcagttcattggctgctTttataattgaaagaggtaag	10	4	1	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr4:123317517T>C	uc003ieo.2	+	7	941	c.709T>C	c.(709-711)TTT>CTT	p.F237L	ADAD1_uc003iep.2_Missense_Mutation_p.F237L|ADAD1_uc003ieq.2_Missense_Mutation_p.F219L	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	237					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						ATTGGCTGCTTTTATAATTGA	0.279													C	123317517	C	C	123317517	3	2	211	1	0	0	0	0	1	0	0	0	231	1841	64	4	727	4	ADAD1	4	123317517	Missense_Mutation	SNP	T	TCGA-28-5209-01A-01D-1486-08	26555312	123317517	67836759	18	14817											
RASGRF2	5924	broad.mit.edu	37	chr5	80382758	80382758	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgctggacaccagccaaaCgttcatccgccaaggtaagt	9	13	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr5:80382758C>T	uc003kha.1	+	9	1376	c.1376C>T	c.(1375-1377)ACG>ATG	p.T459M	RASGRF2_uc011ctn.1_RNA|RASGRF2_uc003khb.1_Missense_Mutation_p.T287M	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	459					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		ACCAGCCAAACGTTCATCCGC	0.532													T	80382758	T	T	80382758	3	4	211	1	0	0	0	0	1	0	0	0	13073	536	19	1	1410	1	RASGRF2	5	80382758	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		80382758	100532502	19	14818											
SLC22A5	6584	broad.mit.edu	37	chr5	131729923	131729923	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acacaaggatgttaaaagatGgtcaagaaaggcccacaatc	9	8	1	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr5:131729923G>T	uc003kww.3	+	10	1897	c.1633G>T	c.(1633-1635)GGT>TGT	p.G545C	SLC22A5_uc003kwx.3_Missense_Mutation_p.G569C	NM_003060	NP_003051	O76082	S22A5_HUMAN	solute carrier family 22 member 5	545					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity				0		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GTTAAAAGATGGTCAAGAAAG	0.393													T	131729923	T	T	131729923	3	4	211	1	0	0	0	0	1	0	0	0	14457	1348	47	5	1671	5	SLC22A5	5	131729923	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	51347165	131729923	49185337	20	14819											
PCDHGB3	56102	broad.mit.edu	37	chr5	140751480	140751480	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgtcgtcctacgtgtccGtgagcgcgcggagcggggtg	18	11	0	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr5:140751480G>A	uc003ljw.1	+	1	1519	c.1519G>A	c.(1519-1521)GTG>ATG	p.V507M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.V507M|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	507	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACGTGTCCGTGAGCGCGCG	0.667													A	140751480	A	A	140751480	3	1	211	1	0	0	0	0	1	0	0	0	11564	1145	40	1	1521	1	PCDHGB3	5	140751480	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	9021557	140751480	40163780	21	14820											
GRM6	2916	broad.mit.edu	37	chr5	178408768	178408768	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctggatggaagaggatgaCgtaggttttgggtacgtaga	16	4	1	3			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr5:178408768C>T	uc003mjr.2	-	10	2703	c.2524G>A	c.(2524-2526)GTC>ATC	p.V842I	GRM6_uc003mjq.2_Missense_Mutation_p.V245I	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	842	Helical; Name=7; (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AAGAGGATGACGTAGGTTTTG	0.587													T	178408768	T	T	178408768	3	4	211	1	0	0	0	0	1	0	0	0	6801	536	19	1	113	1	GRM6	5	178408768	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	37657288	178408768	2506492	22	14821											
LRFN2	57497	broad.mit.edu	37	chr6	40359728	40359728	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggagctgccaaaagtccccCgggcccccaccaggtcactc	10	19	1	0	rs146316351	byFrequency	TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr6:40359728C>T	uc003oph.1	-	3	2789	c.2324G>A	c.(2323-2325)CGG>CAG	p.R775Q		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	775	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					AAAAGTCCCCCGGGCCCCCAC	0.607													T	40359728	T	T	40359728	3	4	211	1	0	0	0	0	1	0	0	0	8938	652	23	2	49	2	LRFN2	6	40359728	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		40359728	130755339	23	14822											
TTBK1	84630	broad.mit.edu	37	chr6	43222352	43222352	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatgctggacttcgggctggCccggcagtacaccaacacca	11	14	0	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr6:43222352C>T	uc003ouq.1	+	6	818	c.539C>T	c.(538-540)GCC>GTC	p.A180V		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	180	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TTCGGGCTGGCCCGGCAGTAC	0.652													T	43222352	T	T	43222352	3	4	211	1	0	0	0	0	1	0	0	0	16673	739	26	3	557	3	TTBK1	6	43222352	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	2862624	43222352	127892715	24	14823											
DEFB114	245928	broad.mit.edu	37	chr6	49928132	49928132	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccgtaacgtttggtgcaaCgatcagcattcaccaaggta	10	10	2	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr6:49928132C>T	uc011dwp.1	-	2	83	c.83G>A	c.(82-84)CGT>CAT	p.R28H		NM_001037499	NP_001032588	Q30KQ6	DB114_HUMAN	beta-defensin 114 precursor	28					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					TTTGGTGCAACGATCAGCATT	0.353													T	49928132	T	T	49928132	3	4	211	1	0	0	0	0	1	0	0	0	4403	536	19	1	129	1	DEFB114	6	49928132	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	6705780	49928132	121186935	25	14824											
SYNJ2	8871	broad.mit.edu	37	chr6	158483053	158483053	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggcttcttgccacgcgggCgacacgcctatgatcaattt	11	12	2	1	rs142499089		TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr6:158483053C>T	uc003qqx.1	+	8	1059	c.984C>T	c.(982-984)GGC>GGT	p.G328G	SYNJ2_uc011efm.1_Intron|SYNJ2_uc003qqw.1_Silent_p.G328G|SYNJ2_uc003qqy.1_Silent_p.G41G|SYNJ2_uc011efn.1_Intron|SYNJ2_uc010kjo.1_Silent_p.G277G|SYNJ2_uc003qqz.1_5'UTR	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	328	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		GCCACGCGGGCGACACGCCTA	0.388													T	158483053	T	T	158483053	2	4	211	1	0	0	0	0	0	0	0	1	15450	755	27	1		1	SYNJ2	6	158483053	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	108554921	158483053	12632014	26	14825											
CARD11	84433	broad.mit.edu	37	chr7	2953020	2953020	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgaagagcacgggccggcGgcgctcgcagtagaaggcgc	18	11	0	3			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:2953020G>A	uc003smv.2	-	22	3324	c.2920C>T	c.(2920-2922)CGC>TGC	p.R974C		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	974	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		ACGGGCCGGCGGCGCTCGCAG	0.652			Mis		DLBCL								A	2953020	A	A	2953020	3	1	211	1	0	0	0	0	1	0	0	0	2645	1116	39	2	560	2	CARD11	7	2953020	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08		2953020	156185643	27	14826											
CCDC129	223075	broad.mit.edu	37	chr7	31682505	31682505	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgatggaggaagagtttctGcttgaggccatggaggggcc	18	6	1	3			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:31682505G>A	uc003tcj.1	+	11	2514	c.1521G>A	c.(1519-1521)CTG>CTA	p.L507L	CCDC129_uc011kad.1_Silent_p.L517L|CCDC129_uc003tci.1_Silent_p.L358L|CCDC129_uc011kae.1_Silent_p.L533L|CCDC129_uc003tck.1_Silent_p.L415L	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	507											0						AAGAGTTTCTGCTTGAGGCCA	0.532													A	31682505	A	A	31682505	2	1	211	1	0	0	0	0	0	0	0	1	2764	1306	46	3		3	CCDC129	7	31682505	Silent	SNP	G	TCGA-28-5209-01A-01D-1486-08	28729485	31682505	127456158	28	14827											
AEBP1	165	broad.mit.edu	37	chr7	44146386	44146386	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggccaccaagaagcccccGtcagggaagaggccccccat	11	16	1	2	rs144974496		TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:44146386G>A	uc003tkb.2	+	2	800	c.495G>A	c.(493-495)CCG>CCA	p.P165P		NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	165	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGAAGCCCCCGTCAGGGAAGA	0.652													A	44146386	A	A	44146386	2	1	211	1	0	0	0	0	0	0	0	1	349	1132	40	1		1	AEBP1	7	44146386	Silent	SNP	G	TCGA-28-5209-01A-01D-1486-08	12463881	44146386	114992277	29	14828											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:55233043G>C	uc003tqk.2	+	15	2039	c.1793G>C	c.(1792-1794)GGA>GCA	p.G598A	EGFR_uc003tqi.2_Missense_Mutation_p.G598A|EGFR_uc003tqj.2_Missense_Mutation_p.G598A|EGFR_uc010kzg.1_Missense_Mutation_p.G553A|EGFR_uc011kco.1_Missense_Mutation_p.G545A|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			C	55233043	C	C	55233043	3	2	211	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	11086657	55233043	103905620	30	14829											
EGFR	1956	broad.mit.edu	37	chr7	55268064	55268064	+	Silent	SNP	C	T	T													cgtgagttgatcatcgaattCtccaaaatggcccgagaccc							TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:55268064C>T	uc003tqk.2	+	24	3150	c.2904C>T	c.(2902-2904)TTC>TTT	p.F968F	EGFR_uc010kzg.1_Silent_p.F923F|EGFR_uc011kco.1_Silent_p.F915F	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	968	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.F968L(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCATCGAATTCTCCAAAATGG	0.478		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55268064	T	T	55268064	2	4	211	1	0	0	0	0	0	0	0	1	4967	912	32	3		3	EGFR	7	55268064	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	35021	55268064	103870599	31	14830	17	2									
EGFR	1956	broad.mit.edu	37	chr7	55268067	55268067	+	Silent	SNP	C	G	G													gagttgatcatcgaattctcCaaaatggcccgagaccccca							TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:55268067C>G	uc003tqk.2	+	24	3153	c.2907C>G	c.(2905-2907)TCC>TCG	p.S969S	EGFR_uc010kzg.1_Silent_p.S924S|EGFR_uc011kco.1_Silent_p.S916S	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	969	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCGAATTCTCCAAAATGGCCC	0.483		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			G	55268067	G	G	55268067	2	3	211	1	0	0	0	0	0	0	0	1	4967	581	21	5		5	EGFR	7	55268067	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	3	55268067	103870596	32	14831	17	2									
CHCHD2	51142	broad.mit.edu	37	chr7	56170668	56170670	+	In_Frame_Del	DEL	GCT	-	-													tttgatctcatagaggcaagGctgctgctgctgtgctggct							TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:56170668_56170670delGCT	uc003tsa.2	-	3	416_418	c.335_337delAGC	c.(334-339)CAGCCT>CCT	p.Q112del	PSPH_uc003trj.2_Intron	NM_016139	NP_057223	Q9Y6H1	CHCH2_HUMAN	coiled-coil-helix-coiled-coil-helix domain	112	CHCH.					mitochondrion					0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TAGAGGCAAGGCTGCTGCTGCTG	0.488													-	56170670	-	-	56170668	7	5	211	1	0	1	0	1	0	0	0	0	3316	1203	42	0	126	0	CHCHD2	7	56170668	In_Frame_Del	DEL	GCT	TCGA-28-5209-01A-01D-1486-08	902601	56170668	102967995	33	14832											
CALN1	83698	broad.mit.edu	37	chr7	71252855	71252855	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcatatgaggctcttccggaCgcaggtctgtctgttctgct	12	11	4	1	rs144352678	by1000genomes	TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:71252855C>T	uc003twa.3	-	6	1092	c.565G>A	c.(565-567)GTC>ATC	p.V189I	CALN1_uc003twb.3_Missense_Mutation_p.V231I|CALN1_uc003twc.3_Missense_Mutation_p.V189I	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	189	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CTCTTCCGGACGCAGGTCTGT	0.537													T	71252855	T	T	71252855	3	4	211	1	0	0	0	0	1	0	0	0	2591	536	19	1	98	1	CALN1	7	71252855	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	15082187	71252855	87885808	34	14833											
SEMA3E	9723	broad.mit.edu	37	chr7	83032082	83032082	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gacacatatagcatgccctcGaaaaatattactgaaaaata	5	8	0	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:83032082G>A	uc003uhy.1	-	10	1475	c.1009C>T	c.(1009-1011)CGA>TGA	p.R337*		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	337	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				GCATGCCCTCGAAAAATATTA	0.403													A	83032082	A	A	83032082	4	1	211	1	0	0	0	0	0	1	0	0	14028	1066	37	2	1350	2	SEMA3E	7	83032082	Nonsense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	11779227	83032082	76106581	35	14834											
ABCB4	5244	broad.mit.edu	37	chr7	87074204	87074204	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aataatatcaaagatcacatAtgctgctcctcttgcattgg	6	9	3	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:87074204A>G	uc003uiv.1	-	10	1169	c.1093T>C	c.(1093-1095)TAT>CAT	p.Y365H	ABCB4_uc003uiw.1_Missense_Mutation_p.Y365H|ABCB4_uc003uix.1_Missense_Mutation_p.Y365H	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	365	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AAGATCACATATGCTGCTCCT	0.343													G	87074204	G	G	87074204	3	3	211	1	0	0	0	0	1	0	0	0	43	449	16	4	2843	4	ABCB4	7	87074204	Missense_Mutation	SNP	A	TCGA-28-5209-01A-01D-1486-08	4042122	87074204	72064459	36	14835											
COL1A2	1278	broad.mit.edu	37	chr7	94054949	94054949	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgggaacgatggtcccccaGgtcgcgatggtcaacccgga	14	13	1	0	rs72659309		TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:94054949G>T	uc003ung.1	+	43	3280	c.2809G>T	c.(2809-2811)GGT>TGT	p.G937C	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	937					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging	p.G937S(1)	COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGGTCCCCCAGGTCGCGATGG	0.478										HNSCC(75;0.22)			T	94054949	T	T	94054949	3	4	211	1	0	0	0	0	1	0	0	0	3678	1000	35	5	2979	5	COL1A2	7	94054949	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	6980745	94054949	65083714	37	14836											
CUX1	1523	broad.mit.edu	37	chr7	101926060	101926060	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggactgtgccaccttctgCgccaagaagtgaggaccccc	12	14	1	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:101926060C>T	uc003uyt.2	+	22	1978	c.1959C>T	c.(1957-1959)TGC>TGT	p.C653C	CUX1_uc011kkn.1_Silent_p.C614C|CUX1_uc003uyw.2_Silent_p.C607C|CUX1_uc003uyv.2_Silent_p.C637C|CUX1_uc003uyu.2_Silent_p.C651C|CUX1_uc003uyz.2_RNA|SH2B2_uc011kko.1_5'Flank	NM_001913	NP_001904	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform b	Error:Variant_position_missing_in_P39880_after_alignment					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CCACCTTCTGCGCCAAGAAGT	0.662													T	101926060	T	T	101926060	2	4	211	1	0	0	0	0	0	0	0	1	4064	776	27	1		1	CUX1	7	101926060	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	7871111	101926060	57212603	38	14837											
SVOPL	136306	broad.mit.edu	37	chr7	138305873	138305873	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaaagcgcgcatcgtggtgGggtagacctgcagggagagg	18	9	0	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr7:138305873G>A	uc011kqh.1	-	13	1271	c.1271C>T	c.(1270-1272)CCC>CTC	p.P424L	SVOPL_uc003vue.2_Missense_Mutation_p.P272L	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	424						integral to membrane	transmembrane transporter activity				0						CATCGTGGTGGGGTAGACCTG	0.587													A	138305873	A	A	138305873	3	1	211	1	0	0	0	0	1	0	0	0	15421	1232	43	3	219	3	SVOPL	7	138305873	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	36379813	138305873	20832790	39	14838											
EPPK1	83481	broad.mit.edu	37	chr8	144940353	144940353	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaggccacgtccacgggcaCgcggtggctgtgcacggggt	18	12	0	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr8:144940353C>T	uc003zaa.1	-	2	15092	c.15079G>A	c.(15079-15081)GTG>ATG	p.V5027M		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5027	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCACGGGCACGCGGTGGCTG	0.692													T	144940353	T	T	144940353	3	4	211	1	0	0	0	0	1	0	0	0	5190	536	19	1	197	1	EPPK1	8	144940353	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		144940353	1423669	40	14839											
ARMC4	55130	broad.mit.edu	37	chr10	28228843	28228843	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctggtaaatggccatggCgcagtgctcctgcagctgct	12	13	0	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr10:28228843C>T	uc009xky.2	-	14	2178	c.2080G>A	c.(2080-2082)GCC>ACC	p.A694T	ARMC4_uc010qds.1_Missense_Mutation_p.A219T|ARMC4_uc010qdt.1_Missense_Mutation_p.A386T|ARMC4_uc001itz.2_Missense_Mutation_p.A694T	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	694	ARM 4.|HEAT.						binding			ovary(4)|skin(2)	6						ATGGCCATGGCGCAGTGCTCC	0.458													T	28228843	T	T	28228843	3	4	211	1	0	0	0	0	1	0	0	0	953	768	27	1	1082	1	ARMC4	10	28228843	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		28228843	107305904	41	14840											
HNRNPF	3185	broad.mit.edu	37	chr10	43882701	43882701	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctggcagtcccgggccggTcatagggccctggccgctgc	15	16	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr10:43882701T>C	uc009xmh.1	-	3	1119	c.632A>G	c.(631-633)GAC>GGC	p.D211G	HNRNPF_uc001jar.2_Missense_Mutation_p.D211G|HNRNPF_uc001jas.2_Missense_Mutation_p.D211G|HNRNPF_uc001jat.2_Missense_Mutation_p.D211G|HNRNPF_uc001jav.2_Missense_Mutation_p.D211G|HNRNPF_uc001jau.2_Missense_Mutation_p.D211G|uc010qfa.1_Missense_Mutation_p.V128A	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	211					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						CCCGGGCCGGTCATAGGGCCC	0.592													C	43882701	C	C	43882701	3	2	211	1	0	0	0	0	1	0	0	0	7265	1667	58	4	619	4	HNRNPF	10	43882701	Missense_Mutation	SNP	T	TCGA-28-5209-01A-01D-1486-08	15653858	43882701	91652046	42	14841											
PTEN	5728	broad.mit.edu	37	chr10	89717695	89717696	+	Frame_Shift_Ins	INS	-	T	T													gggaagacaagttcatgtacINStttgagttccctcagccgtt							TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr10:89717695_89717696insT	uc001kfb.2	+	8	1751_1752	c.720_721insT	c.(718-723)TACTTTfs	p.Y240fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	240_241	C2 tensin-type.		F -> S (in MCEPHAS).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.F241L(1)|p.G165_*404del(1)|p.?(1)|p.G165_K342del(1)|p.F241fs*1(1)|p.R234fs*9(1)|p.K237_Y240>N(1)|p.F241fs*17(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGTTCATGTACTTTGAGTTCCC	0.411		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89717696	T	T	89717695	7	5	211	1	0	1	1	0	0	0	0	0	12738	576	20	0	746	0	PTEN	10	89717695	Frame_Shift_Ins	INS	-	TCGA-28-5209-01A-01D-1486-08	45834994	89717695	45817052	43	14842											
PI4K2A	55361	broad.mit.edu	37	chr10	99426254	99426254	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cattttctcaggagatcaaaGatctgatccttccaaagata	6	9	3	4			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr10:99426254G>T	uc001kog.1	+	7	1201	c.1144G>T	c.(1144-1146)GAT>TAT	p.D382Y	PI4K2A_uc010qoy.1_Missense_Mutation_p.D352Y|PI4K2A_uc009xvw.1_Intron	NM_018425	NP_060895	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	382	PI3K/PI4K.				phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			lung(1)|skin(1)	2		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		GGAGATCAAAGATCTGATCCT	0.468													T	99426254	T	T	99426254	3	4	211	1	0	0	0	0	1	0	0	0	11871	942	33	5	1170	5	PI4K2A	10	99426254	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	9708559	99426254	36108493	44	14843											
BTRC	8945	broad.mit.edu	37	chr10	103190197	103190197	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aacccagggactggcgcactCacagctttccaggtactttc	9	14	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr10:103190197C>T	uc001kta.2	+	2	257	c.144C>T	c.(142-144)CTC>CTT	p.L48L	BTRC_uc001ksz.1_Intron|BTRC_uc001ktb.2_Intron|BTRC_uc001ktc.2_Silent_p.L48L	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	48					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		CTGGCGCACTCACAGCTTTCC	0.527													T	103190197	T	T	103190197	2	4	211	1	0	0	0	0	0	0	0	1	1569	813	29	3		3	BTRC	10	103190197	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	3763943	103190197	32344550	45	14844											
DMBT1	1755	broad.mit.edu	37	chr10	124345651	124345651	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgagtggaggtcctataccGaggctcctggggcaccgtgt	15	12	0	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr10:124345651G>A	uc001lgk.1	+	16	1641	c.1535G>A	c.(1534-1536)CGA>CAA	p.R512Q	DMBT1_uc001lgl.1_Missense_Mutation_p.R502Q|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Missense_Mutation_p.R512Q|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	512	SRCR 4.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTCCTATACCGAGGCTCCTGG	0.592													A	124345651	A	A	124345651	3	1	211	1	0	0	0	0	1	0	0	0	4577	1058	37	2	1597	2	DMBT1	10	124345651	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	21155454	124345651	11189096	46	14845											
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5625849	5625849	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttttatcagagagaagaaaaCatcctggaaggcaagggaga	12	5	1	4			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr11:5625849C>A	uc001mbf.2	+	3	837	c.593C>A	c.(592-594)ACA>AAA	p.T198K	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_Missense_Mutation_p.T144K|TRIM6_uc010qzj.1_5'UTR|TRIM6_uc001mbc.1_Missense_Mutation_p.T170K|TRIM6_uc001mbe.2_5'UTR|TRIM6_uc010qzk.1_5'UTR|TRIM6_uc010qzl.1_Intron|TRIM6_uc001mbd.2_Missense_Mutation_p.T198K|TRIM6_uc001mbg.1_5'Flank|TRIM6_uc009yep.1_5'Flank	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	198						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		GAGAAGAAAACATCCTGGAAG	0.468													A	5625849	A	A	5625849	3	1	211	1	0	0	0	0	1	0	0	0	16531	478	17	5	603	5	TRIM6-TRIM34	11	5625849	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		5625849	129380667	47	14846											
COPB1	1315	broad.mit.edu	37	chr11	14498486	14498486	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tctccaagggacctgcggatCtcagtcatcacactctgaat	8	13	5	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr11:14498486C>A	uc001mli.2	-	12	1741	c.1434G>T	c.(1432-1434)GAG>GAT	p.E478D	COPB1_uc001mlg.2_Missense_Mutation_p.E478D|COPB1_uc001mlh.2_Missense_Mutation_p.E478D	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	478					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						ACCTGCGGATCTCAGTCATCA	0.373													A	14498486	A	A	14498486	3	1	211	1	0	0	0	0	1	0	0	0	3728	912	32	5	1471	5	COPB1	11	14498486	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	8872637	14498486	120508030	48	14847											
KCNA4	3739	broad.mit.edu	37	chr11	30033178	30033178	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgctgaagtatcattcaacaAcccaccatgcccgccagcac	6	16	2	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr11:30033178A>T	uc001msk.2	-	2	2200	c.1048T>A	c.(1048-1050)TTG>ATG	p.L350M		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	350						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCATTCAACAACCCACCATGC	0.478													T	30033178	T	T	30033178	3	4	211	1	0	0	0	0	1	0	0	0	8005	40	2	5	917	5	KCNA4	11	30033178	Missense_Mutation	SNP	A	TCGA-28-5209-01A-01D-1486-08	15534692	30033178	104973338	49	14848											
LRP4	4038	broad.mit.edu	37	chr11	46900805	46900805	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggtctgccagtcagtccaaTagatgcgctctccatagagg	11	11	3	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr11:46900805T>C	uc001ndn.3	-	21	3022	c.2876A>G	c.(2875-2877)TAT>TGT	p.Y959C		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	959	Extracellular (Potential).|LDL-receptor class B 10.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GTCAGTCCAATAGATGCGCTC	0.567													C	46900805	C	C	46900805	3	2	211	1	0	0	0	0	1	0	0	0	8959	1406	49	4	2913	4	LRP4	11	46900805	Missense_Mutation	SNP	T	TCGA-28-5209-01A-01D-1486-08	16867627	46900805	88105711	50	14849											
MS4A15	219995	broad.mit.edu	37	chr11	60531221	60531221	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcacgatgtctgcagctccCgccagcaatggagtgtttgt	12	11	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr11:60531221C>T	uc009ynf.1	+	2	235	c.15C>T	c.(13-15)CCC>CCT	p.P5P	MS4A15_uc001npx.2_Intron|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Silent_p.P5P	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	5						integral to membrane	receptor activity			lung(1)	1						CTGCAGCTCCCGCCAGCAATG	0.527													T	60531221	T	T	60531221	2	4	211	1	0	0	0	0	0	0	0	1	9859	639	23	2		2	MS4A15	11	60531221	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	13630416	60531221	74475295	51	14850											
PGA5	5222	broad.mit.edu	37	chr11	61018718	61018718	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actttaccgtcttcgacaggGcaaacaaccaggtcggcctg	10	13	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr11:61018718G>A	uc001nqz.2	+	9	1162	c.1132G>A	c.(1132-1134)GCA>ACA	p.A378T		NM_014224	NP_055039	P00790	PEPA_HUMAN	pepsinogen 5, group I precursor	378					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			skin(1)	1						CTTCGACAGGGCAAACAACCA	0.557													A	61018718	A	A	61018718	3	1	211	1	0	0	0	0	1	0	0	0	11772	1203	42	3	1166	3	PGA5	11	61018718	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	487497	61018718	73987798	52	14851											
MMP27	64066	broad.mit.edu	37	chr11	102573550	102573550	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	accacccagacccggaccagGaggaaaggcatggccaagca	12	14	0	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr11:102573550G>A	uc001phd.1	-	4	576	c.553C>T	c.(553-555)CCT>TCT	p.P185S		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	185					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		CCCGGACCAGGAGGAAAGGCA	0.458													A	102573550	A	A	102573550	3	1	211	1	0	0	0	0	1	0	0	0	9664	1174	41	3	1016	3	MMP27	11	102573550	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	41554832	102573550	32432966	53	14852											
DSCAML1	57453	broad.mit.edu	37	chr11	117342628	117342628	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctccttgcttggttcactgCggccaatcttgttgaaagag	11	10	2	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr11:117342628C>T	uc001prh.1	-	15	3091	c.3089G>A	c.(3088-3090)CGC>CAC	p.R1030H		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	970	Extracellular (Potential).|Fibronectin type-III 1.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGGTTCACTGCGGCCAATCTT	0.587													T	117342628	T	T	117342628	3	4	211	1	0	0	0	0	1	0	0	0	4769	768	27	1	3328	1	DSCAML1	11	117342628	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	14769078	117342628	17663888	54	14853											
DPPA3	359787	broad.mit.edu	37	chr12	7869602	7869602	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgtccctgcagtttctgcGtgtctaatggatgggatcct	11	9	2	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:7869602G>A	uc001qtf.2	+	4	487	c.409G>A	c.(409-411)GTG>ATG	p.V137M		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	137						cytoplasm|nucleus					0				Kidney(36;0.0887)		CAGTTTCTGCGTGTCTAATGG	0.378													A	7869602	A	A	7869602	3	1	211	1	0	0	0	0	1	0	0	0	4735	1145	40	1	423	1	DPPA3	12	7869602	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08		7869602	125982293	55	14854											
CLEC4E	26253	broad.mit.edu	37	chr12	8689778	8689778	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcagttctttaaacttaacGcccaggaaatggtgtcagta	9	8	2	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:8689778G>A	uc001quo.1	-	4	470	c.305C>T	c.(304-306)GCG>GTG	p.A102V		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	102	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					TAAACTTAACGCCCAGGAAAT	0.458													A	8689778	A	A	8689778	3	1	211	1	0	0	0	0	1	0	0	0	3515	1087	38	1	366	1	CLEC4E	12	8689778	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	820176	8689778	125162117	56	14855											
ABCC9	10060	broad.mit.edu	37	chr12	21991021	21991021	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtttactcacctaaaggccCgaatggtggtgagtccttct	10	10	2	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:21991021C>T	uc001rfi.1	-	28	3577	c.3557G>A	c.(3556-3558)CGG>CAG	p.R1186Q	ABCC9_uc001rfh.2_Missense_Mutation_p.R1186Q|ABCC9_uc001rfj.1_Missense_Mutation_p.R1150Q	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1186	Extracellular (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCTAAAGGCCCGAATGGTGGT	0.423													T	21991021	T	T	21991021	3	4	211	1	0	0	0	0	1	0	0	0	59	652	23	2	1278	2	ABCC9	12	21991021	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	13301243	21991021	111860874	57	14856											
ADCY6	112	broad.mit.edu	37	chr12	49164592	49164592	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggagtgctcattgatgtgCttcatctgctccatgagccg	11	10	3	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:49164592C>T	uc001rsh.3	-	19	3873	c.3213G>A	c.(3211-3213)AAG>AAA	p.K1071K	ADCY6_uc001rsj.3_Silent_p.K1071K|ADCY6_uc001rsi.3_Silent_p.K1018K|ADCY6_uc010slw.1_3'UTR	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	1071	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CATTGATGTGCTTCATCTGCT	0.552													T	49164592	T	T	49164592	2	4	211	1	0	0	0	0	0	0	0	1	298	796	28	3		3	ADCY6	12	49164592	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	27173571	49164592	84687303	58	14857											
CACNB3	784	broad.mit.edu	37	chr12	49221583	49221583	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctgcctagtgctaacggGcatgacccccaagaccggct	13	14	0	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:49221583G>A	uc001rsl.1	+	13	1557	c.1356G>A	c.(1354-1356)GGG>GGA	p.G452G	CACNB3_uc010sly.1_Silent_p.G439G|CACNB3_uc010slz.1_Silent_p.G451G|CACNB3_uc001rsk.1_Silent_p.G299G	NM_000725	NP_000716	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3	452					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0					Verapamil(DB00661)	GTGCTAACGGGCATGACCCCC	0.622													A	49221583	A	A	49221583	2	1	211	1	0	0	0	0	0	0	0	1	2554	1190	42	3		3	CACNB3	12	49221583	Silent	SNP	G	TCGA-28-5209-01A-01D-1486-08	56991	49221583	84630312	59	14858											
TUBA1B	10376	broad.mit.edu	37	chr12	49523423	49523423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggccatcgggctggatgCcgtgttccaggcagtagagc	15	11	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:49523423C>T	uc001rtm.2	-	2	307	c.86G>A	c.(85-87)GGC>GAC	p.G29D	TUBA1B_uc001rto.2_Intron|TUBA1B_uc001rtk.2_5'UTR|TUBA1B_uc001rtl.2_5'UTR|TUBA1B_uc001rtn.2_5'UTR	NM_006082	NP_006073	P68363	TBA1B_HUMAN	tubulin, alpha, ubiquitous	29					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding				0						GGGCTGGATGCCGTGTTCCAG	0.582													T	49523423	T	T	49523423	3	4	211	1	0	0	0	0	1	0	0	0	16741	739	26	3	1281	3	TUBA1B	12	49523423	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	301840	49523423	84328472	60	14859											
KRT1	3848	broad.mit.edu	37	chr12	53072002	53072002	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccgcttgttgatttcatccTcatacctgcaggaaagcaga	8	11	2	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:53072002T>C	uc001sau.1	-	3	871	c.812A>G	c.(811-813)GAG>GGG	p.E271G	KRT1_uc001sav.1_Missense_Mutation_p.E271G	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	271	Coil 1B.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						GATTTCATCCTCATACCTGCA	0.403													C	53072002	C	C	53072002	3	2	211	1	0	0	0	0	1	0	0	0	8447	1551	54	4	1150	4	KRT1	12	53072002	Missense_Mutation	SNP	T	TCGA-28-5209-01A-01D-1486-08	3548579	53072002	80779893	61	14860											
TRHDE	29953	broad.mit.edu	37	chr12	73046818	73046818	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttctaaatctgtcactgaatTctgaggtggtgctggatcaa	10	7	5	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:73046818T>A	uc001sxa.2	+	17	2761	c.2731T>A	c.(2731-2733)TCT>ACT	p.S911T		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	911	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GTCACTGAATTCTGAGGTGGT	0.343													A	73046818	A	A	73046818	3	1	211	1	0	0	0	0	1	0	0	0	16476	1783	62	5	2797	5	TRHDE	12	73046818	Missense_Mutation	SNP	T	TCGA-28-5209-01A-01D-1486-08	19974816	73046818	60805077	62	14861											
NUDT4	11163	broad.mit.edu	37	chr12	93792556	93792556	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tattcaagcagaaccaagacCgaaagcacagaacatatgtt	7	9	1	3			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:93792556C>T	uc001tcm.2	+	4	663	c.265C>T	c.(265-267)CGA>TGA	p.R89*	NUDT4_uc010sup.1_Nonsense_Mutation_p.R89*|NUDT4_uc001tcn.2_Nonsense_Mutation_p.R37*|NUDT4_uc010suq.1_Nonsense_Mutation_p.R38*|NUDT4_uc001tco.2_Nonsense_Mutation_p.R37*	NM_019094	NP_061967	Q9NZJ9	NUDT4_HUMAN	nudix-type motif 4 isoform alpha	89	Substrate binding (By similarity).|Nudix hydrolase.				calcium-mediated signaling|cyclic nucleotide metabolic process|cyclic-nucleotide-mediated signaling|intracellular transport|regulation of RNA export from nucleus	cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0						GAACCAAGACCGAAAGCACAG	0.343													T	93792556	T	T	93792556	4	4	211	1	0	0	0	0	0	1	0	0	10741	644	23	2	282	2	NUDT4	12	93792556	Nonsense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	20745738	93792556	40059339	63	14862											
MTERFD3	80298	broad.mit.edu	37	chr12	107371336	107371336	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agcaacaacagtcagtatgtCattcttcaacatttaatggt	6	8	4	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:107371336C>T	uc001tme.1	-	2	2976	c.1157G>A	c.(1156-1158)TGA>TAA	p.*386*	MTERFD3_uc001tmf.1_Silent_p.*386*|MTERFD3_uc001tmg.1_Silent_p.*386*|MTERFD3_uc001tmh.1_3'UTR	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						GTCAGTATGTCATTCTTCAAC	0.358													T	107371336	T	T	107371336	2	4	211	1	0	0	0	0	0	0	0	1	9921	837	29	3		3	MTERFD3	12	107371336	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	13578780	107371336	26480559	64	14863											
WSCD2	9671	broad.mit.edu	37	chr12	108603986	108603986	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acgtgagcgaggcagagtgcGacatggagtgcaagggcgag	19	7	0	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr12:108603986G>A	uc001tms.2	+	4	1330	c.586G>A	c.(586-588)GAC>AAC	p.D196N	WSCD2_uc001tmt.2_Missense_Mutation_p.D196N	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	196	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GGCAGAGTGCGACATGGAGTG	0.682													A	108603986	A	A	108603986	3	1	211	1	0	0	0	0	1	0	0	0	17404	1058	37	2	596	2	WSCD2	12	108603986	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	1232650	108603986	25247909	65	14864											
TUBA3C	7278	broad.mit.edu	37	chr13	19752451	19752451	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatggtgtaatggcctctggCgtaattattggccgcatctt	12	8	2	0	rs145210942		TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr13:19752451C>T	uc009zzj.2	-	3	359	c.310G>A	c.(310-312)GCC>ACC	p.A104T		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	104					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TGGCCTCTGGCGTAATTATTG	0.532													T	19752451	T	T	19752451	3	4	211	1	0	0	0	0	1	0	0	0	16743	768	27	1	1054	1	TUBA3C	13	19752451	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		19752451	95417427	66	14865											
FLT3	2322	broad.mit.edu	37	chr13	28636176	28636176	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagctctggggtctcaacgCacacccgaggtcttccgggg	14	13	3	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr13:28636176C>T	uc001urw.2	-	3	278	c.196G>A	c.(196-198)GCG>ACG	p.A66T	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.A66T	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	66	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.599_560>LTGSSDNEYFYVDFREYEY(1)		haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GGTCTCAACGCACACCCGAGG	0.532			Mis|O		AML|ALL								T	28636176	T	T	28636176	3	4	211	1	0	0	0	0	1	0	0	0	5942	710	25	3	2873	3	FLT3	13	28636176	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	8883725	28636176	86533702	67	14866											
SUCLA2	8803	broad.mit.edu	37	chr13	48571116	48571116	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctttgctgttgctgctgtaCttggagtccatggttattaa	10	8	0	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr13:48571116C>T	uc001vbs.2	-	2	190	c.133G>A	c.(133-135)GTA>ATA	p.V45I	SUCLA2_uc010tgb.1_5'UTR|SUCLA2_uc010tgc.1_5'UTR|SUCLA2_uc010tgd.1_5'UTR|SUCLA2_uc001vbt.1_RNA|SUCLA2_uc001vbu.1_Missense_Mutation_p.V45I	NM_003850	NP_003841	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	45					succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)	1		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	TGCTGCTGTACTTGGAGTCCA	0.403													T	48571116	T	T	48571116	3	4	211	1	0	0	0	0	1	0	0	0	15362	565	20	3	1298	3	SUCLA2	13	48571116	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	19934940	48571116	66598762	68	14867											
KLF5	688	broad.mit.edu	37	chr13	73636601	73636601	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccccttgcacatacacaatGccaagtcagtttcttccaca	4	16	2	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr13:73636601G>A	uc001vje.2	+	2	1188	c.864G>A	c.(862-864)ATG>ATA	p.M288I	KLF5_uc001vjd.2_Missense_Mutation_p.M197I	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	288					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CATACACAATGCCAAGTCAGT	0.522													A	73636601	A	A	73636601	3	1	211	1	0	0	0	0	1	0	0	0	8349	1319	46	3	870	3	KLF5	13	73636601	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	25065485	73636601	41533277	69	14868											
FOXG1	2290	broad.mit.edu	37	chr14	29237185	29237185	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actccatccgccacaatctgTccctcaacaagtgcttcgtg	6	16	2	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr14:29237185T>G	uc001wqe.2	+	1	899	c.700T>G	c.(700-702)TCC>GCC	p.S234A		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	234	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CCACAATCTGTCCCTCAACAA	0.587													G	29237185	G	G	29237185	3	3	211	1	0	0	0	0	1	0	0	0	6007	1667	58	5	702	5	FOXG1	14	29237185	Missense_Mutation	SNP	T	TCGA-28-5209-01A-01D-1486-08		29237185	78112355	70	14869											
SIPA1L1	26037	broad.mit.edu	37	chr14	72176033	72176033	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagtggtacgatggggaccGcacagaatccgaactcaaca	12	10	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr14:72176033G>A	uc001xms.2	+	15	4271	c.3923G>A	c.(3922-3924)CGC>CAC	p.R1308H	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R1287H|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R1287H|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R1308H|SIPA1L1_uc010ttm.1_Missense_Mutation_p.R762H|SIPA1L1_uc001xmw.2_Missense_Mutation_p.R73H	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1308	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GATGGGGACCGCACAGAATCC	0.537													A	72176033	A	A	72176033	3	1	211	1	0	0	0	0	1	0	0	0	14329	1087	38	1	3977	1	SIPA1L1	14	72176033	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	42938848	72176033	35173507	71	14870											
AHNAK2	113146	broad.mit.edu	37	chr14	105413876	105413876	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttggctgtcacacccttgtCggccagggacaggtccccct	11	15	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr14:105413876C>T	uc010axc.1	-	7	8032	c.7912G>A	c.(7912-7914)GAC>AAC	p.D2638N	AHNAK2_uc001ypx.2_Missense_Mutation_p.D2538N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2638						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACACCCTTGTCGGCCAGGGAC	0.602													T	105413876	T	T	105413876	3	4	211	1	0	0	0	0	1	0	0	0	415	884	31	2	9479	2	AHNAK2	14	105413876	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	33237843	105413876	1935664	72	14871											
SPG11	80208	broad.mit.edu	37	chr15	44858195	44858195	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgacagtgctgggcctgtcGcacacaggagtcctgaggaa	14	11	0	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr15:44858195G>A	uc001ztx.2	-	38	6887	c.6856C>T	c.(6856-6858)CGA>TGA	p.R2286*	SPG11_uc010bdw.2_Nonsense_Mutation_p.R416*|SPG11_uc010ueh.1_Nonsense_Mutation_p.R2173*|SPG11_uc010uei.1_Intron	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	2286	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TGGGCCTGTCGCACACAGGAG	0.532													A	44858195	A	A	44858195	4	1	211	1	0	0	0	0	0	1	0	0	15040	1095	38	1	487	1	SPG11	15	44858195	Nonsense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08		44858195	57673197	73	14872											
ACSM2A	123876	broad.mit.edu	37	chr16	20492203	20492203	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggagcaccctgctgtggttgAgacggctgtgatcagcagcc	15	11	1	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr16:20492203A>T	uc010bwe.2	+	13	1708	c.1469A>T	c.(1468-1470)GAG>GTG	p.E490V	ACSM2A_uc010vax.1_Missense_Mutation_p.E411V|ACSM2A_uc002dhf.3_Missense_Mutation_p.E490V|ACSM2A_uc002dhg.3_Missense_Mutation_p.E490V|ACSM2A_uc010vay.1_Missense_Mutation_p.E411V|ACSM2A_uc002dhh.3_Missense_Mutation_p.E120V	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	490					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GCTGTGGTTGAGACGGCTGTG	0.527													T	20492203	T	T	20492203	3	4	211	1	0	0	0	0	1	0	0	0	183	304	11	5	1511	5	ACSM2A	16	20492203	Missense_Mutation	SNP	A	TCGA-28-5209-01A-01D-1486-08		20492203	69862550	74	14873											
DNAH3	55567	broad.mit.edu	37	chr16	21128600	21128600	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaaacaagtttttcttctgCgttaacagttccaaggagca	8	8	2	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr16:21128600C>T	uc010vbe.1	-	12	1738	c.1738G>A	c.(1738-1740)GCA>ACA	p.A580T	DNAH3_uc002die.2_Missense_Mutation_p.A520T	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	580	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTTTCTTCTGCGTTAACAGTT	0.358													T	21128600	T	T	21128600	3	4	211	1	0	0	0	0	1	0	0	0	4603	768	27	1	10815	1	DNAH3	16	21128600	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	636397	21128600	69226153	75	14874											
CHP2	63928	broad.mit.edu	37	chr16	23768582	23768582	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctggagaacatcgctgacCgcacggtgcaggaggctgat	15	10	0	3			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr16:23768582C>T	uc002dmb.1	+	6	898	c.475C>T	c.(475-477)CGC>TGC	p.R159C		NM_022097	NP_071380	O43745	CHP2_HUMAN	hepatocellular carcinoma antigen gene 520	159	EF-hand 4.						calcium ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(48;0.0144)		CATCGCTGACCGCACGGTGCA	0.577													T	23768582	T	T	23768582	3	4	211	1	0	0	0	0	1	0	0	0	3367	652	23	2	497	2	CHP2	16	23768582	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	2639982	23768582	66586171	76	14875											
SLC38A7	55238	broad.mit.edu	37	chr16	58709937	58709937	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgcatgctgttgaagaCgggcacactgctgacgtggc	14	11	0	3			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr16:58709937C>T	uc002eod.1	-	8	1183	c.790G>A	c.(790-792)GTC>ATC	p.V264I	SLC38A7_uc002eob.1_Intron|SLC38A7_uc002eoc.1_Missense_Mutation_p.V264I|SLC38A7_uc010vil.1_Missense_Mutation_p.V175I|SLC38A7_uc002eoe.1_Missense_Mutation_p.V264I	NM_018231	NP_060701	Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	264					amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						CTGTTGAAGACGGGCACACTG	0.572													T	58709937	T	T	58709937	3	4	211	1	0	0	0	0	1	0	0	0	14609	536	19	1	618	1	SLC38A7	16	58709937	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	34941355	58709937	31644816	77	14876											
ATP2A3	489	broad.mit.edu	37	chr17	3840720	3840720	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccggcctcaccagacgacctCgccaacattggaggagatga	11	14	1	3			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr17:3840720C>T	uc002fxb.1	-	15	2462	c.2311G>A	c.(2311-2313)GAG>AAG	p.E771K	ATP2A3_uc002fwx.1_Missense_Mutation_p.E771K|ATP2A3_uc002fwy.1_Missense_Mutation_p.E771K|ATP2A3_uc002fwz.1_Missense_Mutation_p.E771K|ATP2A3_uc002fxa.1_Missense_Mutation_p.E771K|ATP2A3_uc002fxc.1_Missense_Mutation_p.E771K|ATP2A3_uc002fxd.1_Missense_Mutation_p.E771K	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	771	Helical; Name=5; (By similarity).	Calcium 1 (By similarity).			ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CAGACGACCTCGCCAACATTG	0.602													T	3840720	T	T	3840720	3	4	211	1	0	0	0	0	1	0	0	0	1138	893	31	2	927	2	ATP2A3	17	3840720	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		3840720	77354490	78	14877											
C17orf59	54785	broad.mit.edu	37	chr17	8092644	8092645	+	Missense_Mutation	DNP	CC	AA	AA													gcagacggtccacccggcctCccagctcccgactcaaccgc							TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr17:8092644_8092645CC>AA	uc010vut.1	-	1	920_921	c.814_815GG>TT	c.(814-816)GGA>TTA	p.G272L		NM_017622	NP_060092	Q96GS4	CQ059_HUMAN	hypothetical protein LOC54785	272											0						CACCCGGCCTCCCAGCTCCCGA	0.703													AA	8092645	AA	AA	8092644	3	1	211	1	0	0	0	0	1	0	0	0	1867	855	30	5	262	5	C17orf59	17	8092644	Missense_Mutation	DNP	CC	TCGA-28-5209-01A-01D-1486-08	4251924	8092644	73102566	79	14878											
TAOK1	57551	broad.mit.edu	37	chr17	27778581	27778593	+	Frame_Shift_Del	DEL	CAGAGCAGGCAGC	-	-													agcaggatgccatcaactaaCagagcaggcagcctgaagga							TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr17:27778581_27778593delCAGAGCAGGCAGC	uc002hdz.1	+	2	209_221	c.15_27delCAGAGCAGGCAGC	c.(13-27)AACAGAGCAGGCAGCfs	p.N5fs	TAOK1_uc010wbe.1_Frame_Shift_Del_p.N5fs|TAOK1_uc010wbf.1_Frame_Shift_Del_p.N5fs	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	5_9					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			CATCAACTAACAGAGCAGGCAGCCTGAAGGACC	0.46													-	27778593	-	-	27778581	7	5	211	1	0	1	0	1	0	0	0	0	15544	477	17	0	17	0	TAOK1	17	27778581	Frame_Shift_Del	DEL	CAGAGCAGGCAGC	TCGA-28-5209-01A-01D-1486-08	19685937	27778581	53416629	80	14879											
LAMA1	284217	broad.mit.edu	37	chr18	6965403	6965403	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcataaccttcactctgccaCgaaacagctcgatggataaa	6	12	3	0	rs141811330		TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr18:6965403C>A	uc002knm.2	-	50	7173	c.7079G>T	c.(7078-7080)CGT>CTT	p.R2360L	LAMA1_uc002knl.2_5'UTR|LAMA1_uc010wzj.1_Missense_Mutation_p.R1836L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2360	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACTCTGCCACGAAACAGCTC	0.443													A	6965403	A	A	6965403	3	1	211	1	0	0	0	0	1	0	0	0	8605	536	19	5	2204	5	LAMA1	18	6965403	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		6965403	71111845	81	14880											
AFG3L2	10939	broad.mit.edu	37	chr18	12351333	12351333	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctgcctgtcgaaacgcccCggcctaagcagcgcggggtc	13	15	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr18:12351333C>T	uc002kqz.1	-	11	1511	c.1398G>A	c.(1396-1398)CCG>CCA	p.P466P		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	466					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)	CGAAACGCCCCGGCCTAAGCA	0.463													T	12351333	T	T	12351333	2	4	211	1	0	0	0	0	0	0	0	1	360	639	23	2		2	AFG3L2	18	12351333	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	5385930	12351333	65725915	82	14881											
TMPRSS9	360200	broad.mit.edu	37	chr19	2418090	2418090	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacttctccctcacagaccGcatgatctgcgcaggcttcc	7	17	3	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:2418090G>A	uc010xgx.1	+	12	2006	c.2006G>A	c.(2005-2007)CGC>CAC	p.R669H		NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	669	Extracellular (Potential).|Peptidase S1 2.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCACAGACCGCATGATCTGC	0.557													A	2418090	A	A	2418090	3	1	211	1	0	0	0	0	1	0	0	0	16250	1087	38	1	2052	1	TMPRSS9	19	2418090	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08		2418090	56710893	83	14882											
ZNF358	140467	broad.mit.edu	37	chr19	7585507	7585507	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctggcaccagctctggccGcaaccctgaccctggctctg	10	19	2	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:7585507G>A	uc002mgn.2	+	2	1549	c.1379G>A	c.(1378-1380)CGC>CAC	p.R460H	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	460					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						agctctggccgcaaccctgac	0.209													A	7585507	A	A	7585507	3	1	211	1	0	0	0	0	1	0	0	0	17864	1087	38	1	1381	1	ZNF358	19	7585507	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	5167417	7585507	51543476	84	14883											
ICAM1	3383	broad.mit.edu	37	chr19	10394191	10394191	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggaactggcacccctcccCtcttggcagccagtgggcaa	12	15	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:10394191C>T	uc002mnq.2	+	3	685	c.366C>T	c.(364-366)CCC>CCT	p.P122P	ICAM1_uc010xle.1_Intron	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	122	Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	CACCCCTCCCCTCTTGGCAGC	0.637													T	10394191	T	T	10394191	2	4	211	1	0	0	0	0	0	0	0	1	7479	668	24	3		3	ICAM1	19	10394191	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	2808684	10394191	48734792	85	14884											
MAN2B1	4125	broad.mit.edu	37	chr19	12759205	12759205	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgtccatcgtccttcagcagCcttcggtgcacctgggggga	13	14	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:12759205C>G	uc002mub.2	-	21	2524	c.2448G>C	c.(2446-2448)AGG>AGC	p.R816S	MAN2B1_uc010dyv.1_Missense_Mutation_p.R815S	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	816					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						CCTTCAGCAGCCTTCGGTGCA	0.652													G	12759205	G	G	12759205	3	3	211	1	0	0	0	0	1	0	0	0	9216	738	26	5	603	5	MAN2B1	19	12759205	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	2365014	12759205	46369778	86	14885											
EMR2	30817	broad.mit.edu	37	chr19	14865775	14865775	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagggtctcacctgcacatcGtagtgggccatgaggacggc	14	11	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:14865775G>A	uc002mzp.1	-	14	2037	c.1581C>T	c.(1579-1581)TAC>TAT	p.Y527Y	EMR2_uc010dzs.1_Intron|EMR2_uc010xnw.1_Intron|EMR2_uc002mzo.1_Silent_p.Y516Y|EMR2_uc002mzq.1_Silent_p.Y467Y|EMR2_uc002mzr.1_Silent_p.Y478Y|EMR2_uc002mzs.1_Silent_p.Y385Y|EMR2_uc002mzt.1_Silent_p.Y423Y|EMR2_uc002mzu.1_Silent_p.Y434Y|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_Intron	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	527	Extracellular (Potential).|GPS.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						CCTGCACATCGTAGTGGGCCA	0.423													A	14865775	A	A	14865775	2	1	211	1	0	0	0	0	0	0	0	1	5105	1140	40	1		1	EMR2	19	14865775	Silent	SNP	G	TCGA-28-5209-01A-01D-1486-08	2106570	14865775	44263208	87	14886											
ZNF98	148198	broad.mit.edu	37	chr19	22575722	22575722	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatgttctcagtatcactttTtggaaataattttttttgcc	5	6	2	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:22575722T>C	uc002nqt.2	-	4	437	c.315A>G	c.(313-315)CAA>CAG	p.Q105Q		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				GTATCACTTTTTGGAAATAAT	0.299													C	22575722	C	C	22575722	2	2	211	1	0	0	0	0	0	0	0	1	18200	1838	64	4		4	ZNF98	19	22575722	Silent	SNP	T	TCGA-28-5209-01A-01D-1486-08	7709947	22575722	36553261	88	14887											
GPATCH1	55094	broad.mit.edu	37	chr19	33585093	33585093	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctagattatctgttggtttCgaattgctaagaaaaatggg	10	5	1	2	rs149673951		TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:33585093C>T	uc002nug.1	+	5	785	c.471C>T	c.(469-471)TTC>TTT	p.F157F		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	157	G-patch.					catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					CTGTTGGTTTCGAATTGCTAA	0.393													T	33585093	T	T	33585093	2	4	211	1	0	0	0	0	0	0	0	1	6590	883	31	2		2	GPATCH1	19	33585093	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	11009371	33585093	25543890	89	14888											
NPHS1	4868	broad.mit.edu	37	chr19	36336653	36336653	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagtttaaggcgtctcccgGgcgcagtgcggatgcgttgg	16	10	1	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:36336653G>A	uc002oby.2	-	13	1675	c.1675C>T	c.(1675-1677)CCG>TCG	p.P559S		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	559	Ig-like C2-type 6.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCGTCTCCCGGGCGCAGTGCG	0.622													A	36336653	A	A	36336653	3	1	211	1	0	0	0	0	1	0	0	0	10582	1232	43	3	2118	3	NPHS1	19	36336653	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	2751560	36336653	22792330	90	14889											
PLEKHG2	64857	broad.mit.edu	37	chr19	39913516	39913516	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctggagatggatgaacggGggccttccccactccacgtc	14	13	0	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:39913516G>A	uc010xuz.1	+	18	2147	c.1822G>A	c.(1822-1824)GGG>AGG	p.G608R	PLEKHG2_uc010xuy.1_Missense_Mutation_p.G549R|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.G386R	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	608					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGATGAACGGGGGCCTTCCCC	0.587													A	39913516	A	A	39913516	3	1	211	1	0	0	0	0	1	0	0	0	12069	1232	43	3	1888	3	PLEKHG2	19	39913516	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	3576863	39913516	19215467	91	14890											
C5AR1	728	broad.mit.edu	37	chr19	47823297	47823297	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgacttcctctcctgcctggCgctgcccatcttgttcacgt	8	17	3	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:47823297C>T	uc002pgj.1	+	2	312	c.263C>T	c.(262-264)GCG>GTG	p.A88V		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	88	Helical; Name=2; (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		TCCTGCCTGGCGCTGCCCATC	0.602													T	47823297	T	T	47823297	3	4	211	1	0	0	0	0	1	0	0	0	2281	768	27	1	268	1	C5AR1	19	47823297	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	7909781	47823297	11305686	92	14891											
SHANK1	50944	broad.mit.edu	37	chr19	51205832	51205832	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgctgagtagagcttcctccGcctcccgcggctgcccaggg	13	17	0	2	rs148526987		TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:51205832G>A	uc002psx.1	-	11	1658	c.1639C>T	c.(1639-1641)CGG>TGG	p.R547W		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	547					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AGCTTCCTCCGCCTCCCGCGG	0.711													A	51205832	A	A	51205832	3	1	211	1	0	0	0	0	1	0	0	0	14264	1086	38	1	4898	1	SHANK1	19	51205832	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	3382535	51205832	7923151	93	14892											
CD33	945	broad.mit.edu	37	chr19	51729289	51729289	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacctgtcaggtgaagttcGctggagctggtgtgactacg	15	8	1	3	rs150408980	byFrequency	TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:51729289G>A	uc002pwa.2	+	3	689	c.649G>A	c.(649-651)GCT>ACT	p.A217T	CD33_uc010eos.1_Missense_Mutation_p.A217T|CD33_uc010eot.1_Missense_Mutation_p.A90T|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	217	Extracellular (Potential).|Ig-like C2-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GGTGAAGTTCGCTGGAGCTGG	0.622													A	51729289	A	A	51729289	3	1	211	1	0	0	0	0	1	0	0	0	3005	1087	38	1	659	1	CD33	19	51729289	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	523457	51729289	7399694	94	14893											
PEG3	5178	broad.mit.edu	37	chr19	57326473	57326473	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagatccacaaagcccaggcCacagtcctcacattcataga	7	14	2	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:57326473C>T	uc002qnu.2	-	7	3688	c.3337G>A	c.(3337-3339)GGC>AGC	p.G1113S	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G1084S|PEG3_uc002qnv.2_Missense_Mutation_p.G1113S|PEG3_uc002qnw.2_Missense_Mutation_p.G989S|PEG3_uc002qnx.2_Missense_Mutation_p.G987S|PEG3_uc010etr.2_Missense_Mutation_p.G1113S	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1113	C2H2-type 6.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AAGCCCAGGCCACAGTCCTCA	0.488													T	57326473	T	T	57326473	3	4	211	1	0	0	0	0	1	0	0	0	11720	594	21	3	1433	3	PEG3	19	57326473	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	5597184	57326473	1802510	95	14894											
ZNF543	125919	broad.mit.edu	37	chr19	57839653	57839653	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacacctcacacggcaccagCggattcacagtggagagaag	11	13	2	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr19:57839653C>T	uc002qoi.1	+	4	1168	c.823C>T	c.(823-825)CGG>TGG	p.R275W		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	275	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ACGGCACCAGCGGATTCACAG	0.527													T	57839653	T	T	57839653	3	4	211	1	0	0	0	0	1	0	0	0	17973	759	27	1	837	1	ZNF543	19	57839653	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	513180	57839653	1289330	96	14895											
RSPO4	343637	broad.mit.edu	37	chr20	948682	948682	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtactggcggatgccttccCggcggatgaacaggaagagc	15	11	0	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr20:948682C>T	uc002wej.2	-	2	276	c.179G>A	c.(178-180)CGG>CAG	p.R60Q	RSPO4_uc002wek.2_Missense_Mutation_p.R60Q	NM_001029871	NP_001025042	Q2I0M5	RSPO4_HUMAN	R-spondin family, member 4 isoform 1 precursor	60					Wnt receptor signaling pathway	extracellular region	heparin binding				0						GATGCCTTCCCGGCGGATGAA	0.622													T	948682	T	T	948682	3	4	211	1	0	0	0	0	1	0	0	0	13712	652	23	2	541	2	RSPO4	20	948682	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		948682	62076838	97	14896											
PROKR2	128674	broad.mit.edu	37	chr20	5283318	5283318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggacaccatccagaccaaggCgatcaggaaggaggccgttt	13	11	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr20:5283318C>T	uc010zqw.1	-	2	523	c.523G>A	c.(523-525)GCC>ACC	p.A175T	PROKR2_uc010zqx.1_Missense_Mutation_p.A175T|PROKR2_uc010zqy.1_Missense_Mutation_p.A175T	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	175	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CAGACCAAGGCGATCAGGAAG	0.493										HNSCC(71;0.22)			T	5283318	T	T	5283318	3	4	211	1	0	0	0	0	1	0	0	0	12553	768	27	1	634	1	PROKR2	20	5283318	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	4334636	5283318	57742202	98	14897											
PROKR2	128674	broad.mit.edu	37	chr20	5294853	5294853	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccagtgcaatgccaatgaCgatcttggctgcgaagaagg	13	9	1	2	rs146963803	by1000genomes	TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr20:5294853C>T	uc010zqw.1	-	1	163	c.163G>A	c.(163-165)GTC>ATC	p.V55I	PROKR2_uc010zqx.1_Missense_Mutation_p.V55I|PROKR2_uc010zqy.1_Missense_Mutation_p.V55I|uc002wly.1_5'Flank	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	55	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						ATGCCAATGACGATCTTGGCT	0.517										HNSCC(71;0.22)			T	5294853	T	T	5294853	3	4	211	1	0	0	0	0	1	0	0	0	12553	536	19	1	998	1	PROKR2	20	5294853	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	11535	5294853	57730667	99	14898											
PCSK2	5126	broad.mit.edu	37	chr20	17434533	17434533	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaggactgccctgtacgaCgagagctgctcttccacctt	11	14	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr20:17434533C>T	uc002wpm.2	+	9	1352	c.1032C>T	c.(1030-1032)GAC>GAT	p.D344D	PCSK2_uc002wpl.2_Silent_p.D325D|PCSK2_uc010zrm.1_Silent_p.D309D	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	344	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCCTGTACGACGAGAGCTGCT	0.597													T	17434533	T	T	17434533	2	4	211	1	0	0	0	0	0	0	0	1	11601	535	19	1		1	PCSK2	20	17434533	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	12139680	17434533	45590987	100	14899											
TPTE	7179	broad.mit.edu	37	chr21	10951332	10951332	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caatagctagagaaatagaaCgatactccaaaggaatataa	7	6	0	2	rs113140892	byFrequency	TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr21:10951332C>T	uc002yip.1	-	10	748	c.380G>A	c.(379-381)CGT>CAT	p.R127H	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.R109H|TPTE_uc002yir.1_Missense_Mutation_p.R89H|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	127					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGAAATAGAACGATACTCCAA	0.338													T	10951332	T	T	10951332	3	4	211	1	0	0	0	0	1	0	0	0	16427	536	19	1	1335	1	TPTE	21	10951332	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		10951332	37178563	101	14900											
ITGB2	3689	broad.mit.edu	37	chr21	46320316	46320316	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggatggcgcccagcttcccGtcgcccgcgaaatggaagcc	13	15	0	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr21:46320316G>A	uc002zgd.2	-	6	860	c.816C>T	c.(814-816)GAC>GAT	p.D272D	ITGB2_uc002zge.2_Silent_p.D272D|ITGB2_uc002zgf.3_Silent_p.D272D|ITGB2_uc011afl.1_Silent_p.D194D|ITGB2_uc010gpw.2_Silent_p.D215D|ITGB2_uc002zgg.2_Silent_p.D272D	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	272	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	CCAGCTTCCCGTCGCCCGCGA	0.632													A	46320316	A	A	46320316	2	1	211	1	0	0	0	0	0	0	0	1	7894	1136	40	1		1	ITGB2	21	46320316	Silent	SNP	G	TCGA-28-5209-01A-01D-1486-08	35368984	46320316	1809579	102	14901											
ZNF280B	140883	broad.mit.edu	37	chr22	22842526	22842526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctggcacacatagggcatttCgccaggcttatgatggtcct	11	11	0	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr22:22842526C>T	uc002zwc.1	-	4	1974	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TAGGGCATTTCGCCAGGCTTA	0.433													T	22842526	T	T	22842526	3	4	211	1	0	0	0	0	1	0	0	0	17812	893	31	2	437	2	ZNF280B	22	22842526	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08		22842526	28462040	103	14902											
ZNF280A	129025	broad.mit.edu	37	chr22	22868784	22868784	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctggcacacgtagggcatttCgccaggcttatgatggtcct	12	11	0	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr22:22868784C>T	uc002zwe.2	-	2	1424	c.1171G>A	c.(1171-1173)GAA>AAA	p.E391K	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TAGGGCATTTCGCCAGGCTTA	0.453													T	22868784	T	T	22868784	3	4	211	1	0	0	0	0	1	0	0	0	17811	893	31	2	461	2	ZNF280A	22	22868784	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	26258	22868784	28435782	104	14903											
AP1B1	162	broad.mit.edu	37	chr22	29754763	29754763	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttaagggtgtccaggaagccCtggtcctccaccagctgggc	13	13	0	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr22:29754763C>A	uc003afj.2	-	5	661	c.477G>T	c.(475-477)CAG>CAT	p.Q159H	AP1B1_uc003afi.2_Missense_Mutation_p.Q159H|AP1B1_uc003afk.2_Missense_Mutation_p.Q159H|AP1B1_uc003afl.2_Missense_Mutation_p.Q159H	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	159					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CCAGGAAGCCCTGGTCCTCCA	0.597													A	29754763	A	A	29754763	3	1	211	1	0	0	0	0	1	0	0	0	731	680	24	5	2448	5	AP1B1	22	29754763	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	6885979	29754763	21549803	105	14904											
CPT1B	1375	broad.mit.edu	37	chr22	51008725	51008725	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttcaggagcactcacaggGccaaagccacctccagcgcc	9	18	2	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chr22:51008725G>A	uc003bmk.3	-	16	2301	c.2139C>T	c.(2137-2139)GGC>GGT	p.G713G	CPT1B_uc003bml.2_Silent_p.G713G|CPT1B_uc003bmm.2_Silent_p.G713G|CPT1B_uc003bmo.2_Silent_p.G713G|CPT1B_uc011asa.1_Silent_p.G679G|CPT1B_uc003bmn.2_Silent_p.G713G|CPT1B_uc011asb.1_Silent_p.G632G|CHKB-CPT1B_uc003bmp.2_Silent_p.G508G|uc003bmr.1_5'Flank	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	713	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity	p.G713G(1)		ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		CACTCACAGGGCCAAAGCCAC	0.652													A	51008725	A	A	51008725	2	1	211	1	0	0	0	0	0	0	0	1	3832	1190	42	3		3	CPT1B	22	51008725	Silent	SNP	G	TCGA-28-5209-01A-01D-1486-08	21253962	51008725	295841	106	14905											
MAGEB1	4112	broad.mit.edu	37	chrX	30268850	30268850	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtcatgtaccgaatctgaCgaaggtgccaaatgccaagg	12	9	2	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:30268850C>T	uc004dcc.2	+	4	560	c.240C>T	c.(238-240)GAC>GAT	p.D80D	MAGEB1_uc004dcd.2_Silent_p.D80D|MAGEB1_uc004dce.2_Silent_p.D80D	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	80											0						CCGAATCTGACGAAGGTGCCA	0.557													T	30268850	T	T	30268850	2	4	211	1	0	0	0	0	0	0	0	1	9172	535	19	1		1	MAGEB1	23	30268850	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08		30268850	125001710	107	14906											
ZNF157	7712	broad.mit.edu	37	chrX	47272323	47272323	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaatgtgggaaaacatttcGtgtaaagatatcccttaccc	8	8	0	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:47272323G>A	uc004dhr.1	+	4	920	c.851G>A	c.(850-852)CGT>CAT	p.R284H		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	284	C2H2-type 5.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AAAACATTTCGTGTAAAGATA	0.443													A	47272323	A	A	47272323	3	1	211	1	0	0	0	0	1	0	0	0	17734	1145	40	1	865	1	ZNF157	23	47272323	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	17003473	47272323	107998237	108	14907											
SUV39H1	6839	broad.mit.edu	37	chrX	48564987	48564987	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaagaaccatccgggcaggCgaggagctcacctttgatta	11	11	1	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:48564987C>T	uc004dkn.2	+	5	1119	c.1074C>T	c.(1072-1074)GGC>GGT	p.G358G	SUV39H1_uc011mmf.1_Silent_p.G369G|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	358	Mediates interaction with MECOM (By similarity).|SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						TCCGGGCAGGCGAGGAGCTCA	0.592													T	48564987	T	T	48564987	2	4	211	1	0	0	0	0	0	0	0	1	15409	755	27	1		1	SUV39H1	23	48564987	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	1292664	48564987	106705573	109	14908											
ZC3H12B	340554	broad.mit.edu	37	chrX	64722205	64722205	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtttgaatccatgggggacCatggctactattcaatgtta	10	7	1	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:64722205C>A	uc010nko.2	+	5	1603	c.1594C>A	c.(1594-1596)CAT>AAT	p.H532N		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	532							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						CATGGGGGACCATGGCTACTA	0.478													A	64722205	A	A	64722205	3	1	211	1	0	0	0	0	1	0	0	0	17559	594	21	5	1645	5	ZC3H12B	23	64722205	Missense_Mutation	SNP	C	TCGA-28-5209-01A-01D-1486-08	16157218	64722205	90548355	110	14909											
GPR174	84636	broad.mit.edu	37	chrX	78427065	78427065	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagtccgttgttatgatgacCattggcgagttgattgggtt	13	6	0	3			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:78427065C>A	uc004edg.1	+	1	597	c.561C>A	c.(559-561)ACC>ACA	p.T187T		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	187	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						TTATGATGACCATTGGCGAGT	0.458										HNSCC(63;0.18)			A	78427065	A	A	78427065	2	1	211	1	0	0	0	0	0	0	0	1	6672	581	21	5		5	GPR174	23	78427065	Silent	SNP	C	TCGA-28-5209-01A-01D-1486-08	13704860	78427065	76843495	111	14910											
BRWD3	254065	broad.mit.edu	37	chrX	79960260	79960260	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagctgctgcatattttacGtgttgtctgtctggtttgtc	11	7	2	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:79960260G>A	uc004edt.2	-	23	2901	c.2638C>T	c.(2638-2640)CGT>TGT	p.R880C	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.R476C|BRWD3_uc004edp.2_Missense_Mutation_p.R709C|BRWD3_uc004edq.2_Missense_Mutation_p.R476C|BRWD3_uc010nmj.1_Missense_Mutation_p.R476C|BRWD3_uc004edr.2_Missense_Mutation_p.R550C|BRWD3_uc004eds.2_Missense_Mutation_p.R476C|BRWD3_uc004edu.2_Missense_Mutation_p.R550C|BRWD3_uc004edv.2_Missense_Mutation_p.R476C|BRWD3_uc004edw.2_Missense_Mutation_p.R476C|BRWD3_uc004edx.2_Missense_Mutation_p.R476C|BRWD3_uc004edy.2_Missense_Mutation_p.R476C|BRWD3_uc004edz.2_Missense_Mutation_p.R550C|BRWD3_uc004eea.2_Missense_Mutation_p.R550C|BRWD3_uc004eeb.2_Missense_Mutation_p.R476C	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	880										ovary(4)	4						CATATTTTACGTGTTGTCTGT	0.368													A	79960260	A	A	79960260	3	1	211	1	0	0	0	0	1	0	0	0	1526	1145	40	1	2846	1	BRWD3	23	79960260	Missense_Mutation	SNP	G	TCGA-28-5209-01A-01D-1486-08	1533195	79960260	75310300	112	14911											
NRK	203447	broad.mit.edu	37	chrX	105156744	105156744	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atttcaaatcctaaaaaaatTgaggtaaatttttcaatatg	4	4	2	1			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:105156744T>G	uc004emd.2	+	14	2649	c.2346T>G	c.(2344-2346)ATT>ATG	p.I782M	NRK_uc010npc.1_Missense_Mutation_p.I450M	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	782							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						CTAAAAAAATTGAGGTAAATT	0.249										HNSCC(51;0.14)			G	105156744	G	G	105156744	3	3	211	1	0	0	0	0	1	0	0	0	10655	1800	63	5	2400	5	NRK	23	105156744	Missense_Mutation	SNP	T	TCGA-28-5209-01A-01D-1486-08	25196484	105156744	50113816	113	14912											
DOCK11	139818	broad.mit.edu	37	chrX	117748723	117748723	+	Frame_Shift_Del	DEL	C	-	-													gactatatatctggattcagCcccaaagatcctaaggtaag							TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:117748723delC	uc004eqp.2	+	29	3228	c.3165delC	c.(3163-3165)AGCfs	p.S1055fs	DOCK11_uc004eqq.2_Frame_Shift_Del_p.S821fs	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1055					blood coagulation	cytosol	GTP binding			ovary(3)	3						CTGGATTCAGCCCCAAAGATC	0.343													-	117748723	-	-	117748723	7	5	211	1	0	1	0	1	0	0	0	0	4686	738	26	0	3279	0	DOCK11	23	117748723	Frame_Shift_Del	DEL	C	TCGA-28-5209-01A-01D-1486-08	12591979	117748723	37521837	114	14913											
MTMR1	8776	broad.mit.edu	37	chrX	149898608	149898608	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggaacttgcggcttgcttatAaacaggaagaacagagtaaa	11	6	0	2			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:149898608A>G	uc004fei.2	+	6	694	c.559A>G	c.(559-561)AAA>GAA	p.K187E	MTMR1_uc011mya.1_Missense_Mutation_p.K93E|MTMR1_uc004feg.1_Missense_Mutation_p.K187E|MTMR1_uc004feh.1_Missense_Mutation_p.K195E|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_RNA	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	187						plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCTTGCTTATAAACAGGAAGA	0.383													G	149898608	G	G	149898608	3	3	211	1	0	0	0	0	1	0	0	0	9938	363	13	4	581	4	MTMR1	23	149898608	Missense_Mutation	SNP	A	TCGA-28-5209-01A-01D-1486-08	32149885	149898608	5371952	115	14914											
PLXNB3	5365	broad.mit.edu	37	chrX	153032873	153032873	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcctggcgggcaagctgtcGgcaggggtgccacccctggc	18	14	0	0			TCGA-28-5209-01A-01D-1486-08	TCGA-28-5209-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ef8b63f3-b820-46ac-a99c-3d401a6203d7	2b92596c-8041-40ce-846f-c7d11418faf9	g.chrX:153032873G>A	uc004fii.2	+	3	765	c.591G>A	c.(589-591)TCG>TCA	p.S197S	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Intron|PLXNB3_uc010nuk.2_Silent_p.S220S|PLXNB3_uc011mzd.1_Intron	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	197	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GCAAGCTGTCGGCAGGGGTGC	0.716													A	153032873	A	A	153032873	2	1	211	1	0	0	0	0	0	0	0	1	12125	1103	39	2		2	PLXNB3	23	153032873	Silent	SNP	G	TCGA-28-5209-01A-01D-1486-08	3134265	153032873	2237687	116	14915											
KIAA0562	9731	broad.mit.edu	37	chr1	3761888	3761888	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actgaaatctgcagggtctcCaatgatatttatggcaacca	8	9	2	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr1:3761888C>G	uc001aky.2	-	5	813	c.454G>C	c.(454-456)GGA>CGA	p.G152R	KIAA0562_uc010nzm.1_RNA|KIAA0562_uc001akz.2_Missense_Mutation_p.G152R	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	152						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		GCAGGGTCTCCAATGATATTT	0.289													G	3761888	G	G	3761888	3	3	212	1	0	0	0	0	1	0	0	0	8184	603	21	5	2395	5	KIAA0562	1	3761888	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08		3761888	245488733	1	14916											
ABCA4	24	broad.mit.edu	37	chr1	94466600	94466600	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctcccttctctgatgatgCtcacgatgacgttccacagc	7	16	2	3			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr1:94466600C>T	uc001dqh.2	-	46	6448	c.6344G>A	c.(6343-6345)AGC>AAC	p.S2115N		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	2115	ABC transporter 2.|Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCTGATGATGCTCACGATGAC	0.632													T	94466600	T	T	94466600	3	4	212	1	0	0	0	0	1	0	0	0	34	797	28	3	497	3	ABCA4	1	94466600	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08	90704712	94466600	154784021	2	14917											
PPM1J	333926	broad.mit.edu	37	chr1	113252867	113252867	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcttgttgttggggagaCgccagccacggtctcggggg	17	11	1	1	rs113935705	byFrequency	TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr1:113252867C>T	uc001ect.1	-	10	1463	c.1436G>A	c.(1435-1437)CGT>CAT	p.R479H	RHOC_uc001ecq.1_5'Flank|RHOC_uc001ecr.1_5'Flank|RHOC_uc009wgk.1_5'Flank|PPM1J_uc009wgl.1_Intron|PPM1J_uc001ecs.1_Missense_Mutation_p.R273H	NM_005167	NP_005158	Q5JR12	PPM1J_HUMAN	protein phosphatase 1J (PP2C domain containing)	479	PP2C-like.									breast(2)|central_nervous_system(1)	3	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTTGGGGAGACGCCAGCCACG	0.622													T	113252867	T	T	113252867	3	4	212	1	0	0	0	0	1	0	0	0	12342	536	19	1	85	1	PPM1J	1	113252867	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08	18786267	113252867	135997754	3	14918											
TCHH	7062	broad.mit.edu	37	chr1	152082812	152082812	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgcagcttcttatccttccGatattgcctttcccgctcct	5	16	1	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr1:152082812G>A	uc001ezp.2	-	2	2881	c.2881C>T	c.(2881-2883)CGG>TGG	p.R961W	TCHH_uc009wne.1_Missense_Mutation_p.R961W	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	961	4-2.|10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ttatccttcCGATATTGCCTT	0.289													A	152082812	A	A	152082812	3	1	212	1	0	0	0	0	1	0	0	0	15697	1057	37	2	2954	2	TCHH	1	152082812	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08	38829945	152082812	97167809	4	14919											
FLG	2312	broad.mit.edu	37	chr1	152278705	152278705	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctcacactggatccctggCgcctgcttctcctggacccc	10	18	2	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr1:152278705C>T	uc001ezu.1	-	3	8693	c.8657G>A	c.(8656-8658)CGC>CAC	p.R2886H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2886	Ser-rich.|Filaggrin 17.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGATCCCTGGCGCCTGCTTCT	0.562									Ichthyosis				T	152278705	T	T	152278705	3	4	212	1	0	0	0	0	1	0	0	0	5922	768	27	1	3532	1	FLG	1	152278705	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08	195893	152278705	96971916	5	14920											
USH2A	7399	broad.mit.edu	37	chr1	216595382	216595382	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaggcctgctgagaaaagGgcagtgtaggtagggtgtga	18	5	0	3			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr1:216595382G>A	uc001hku.1	-	2	684	c.297C>T	c.(295-297)GCC>GCT	p.A99A	USH2A_uc001hkv.2_Silent_p.A99A	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	99	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.A99V(1)		ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGAGAAAAGGGCAGTGTAGG	0.453										HNSCC(13;0.011)			A	216595382	A	A	216595382	2	1	212	1	0	0	0	0	0	0	0	1	17033	1219	43	3		3	USH2A	1	216595382	Silent	SNP	G	TCGA-28-5211-01C-11D-1845-08	64316677	216595382	32655239	6	14921											
OR2G2	81470	broad.mit.edu	37	chr1	247752222	247752222	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	atctgcgaggtccctgtgctCatcaagctggcttgtgtggg	14	10	3	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr1:247752222C>A	uc010pyy.1	+	1	561	c.561C>A	c.(559-561)CTC>CTA	p.L187L		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCCCTGTGCTCATCAAGCTGG	0.537													A	247752222	A	A	247752222	2	1	212	1	0	0	0	0	0	0	0	1	10998	813	29	5		5	OR2G2	1	247752222	Silent	SNP	C	TCGA-28-5211-01C-11D-1845-08	31156840	247752222	1498399	7	14922											
DYSF	8291	broad.mit.edu	37	chr2	71886153	71886153	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggcctgcagcccaaggaccCcaatggaaaggtaactttcc	10	13	0	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr2:71886153C>G	uc002sie.2	+	43	5160	c.4784C>G	c.(4783-4785)CCC>CGC	p.P1595R	DYSF_uc010feg.2_Missense_Mutation_p.P1626R|DYSF_uc010feh.2_Missense_Mutation_p.P1602R|DYSF_uc002sig.3_Missense_Mutation_p.P1581R|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.P1616R|DYSF_uc010fef.2_Missense_Mutation_p.P1633R|DYSF_uc010fei.2_Missense_Mutation_p.P1612R|DYSF_uc010fek.2_Missense_Mutation_p.P1613R|DYSF_uc010fej.2_Missense_Mutation_p.P1603R|DYSF_uc010fel.2_Missense_Mutation_p.P1582R|DYSF_uc010feo.2_Missense_Mutation_p.P1627R|DYSF_uc010fem.2_Missense_Mutation_p.P1617R|DYSF_uc010fen.2_Missense_Mutation_p.P1634R|DYSF_uc002sif.2_Missense_Mutation_p.P1596R|DYSF_uc010yqy.1_Missense_Mutation_p.P476R|DYSF_uc010yqz.1_Missense_Mutation_p.P356R	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1595	Cytoplasmic (Potential).|C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CCCAAGGACCCCAATGGAAAG	0.517													G	71886153	G	G	71886153	3	3	212	1	0	0	0	0	1	0	0	0	4859	623	22	5	5213	5	DYSF	2	71886153	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08		71886153	171313220	8	14923											
FAM176A	84141	broad.mit.edu	37	chr2	75720533	75720533	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcggcggtgtctccgcacGgagagatcggacacggtgtc	16	11	1	1			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr2:75720533G>A	uc002sni.2	-	4	766	c.288C>T	c.(286-288)TCC>TCT	p.S96S	FAM176A_uc002snj.1_Silent_p.S83S|FAM176A_uc002snk.1_Silent_p.S96S	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	96					apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						GTCTCCGCACGGAGAGATCGG	0.647													A	75720533	A	A	75720533	2	1	212	1	0	0	0	0	0	0	0	1	5499	1103	39	2		2	FAM176A	2	75720533	Silent	SNP	G	TCGA-28-5211-01C-11D-1845-08	3834380	75720533	167478840	9	14924											
NEB	4703	broad.mit.edu	37	chr2	152363440	152363440	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	taccgagctgaaattcttctGattttcttttacacgcagta	6	9	3	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr2:152363440G>T	uc010fnx.2	-	135	18627	c.18436C>A	c.(18436-18438)CAG>AAG	p.Q6146K	NEB_uc002txr.2_Missense_Mutation_p.Q2569K|RIF1_uc002txp.2_Intron|NEB_uc010zca.1_5'Flank|NEB_uc010zcb.1_5'UTR|NEB_uc002txt.3_Missense_Mutation_p.Q651K	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	6146	Nebulin 168.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AAATTCTTCTGATTTTCTTTT	0.318													T	152363440	T	T	152363440	3	4	212	1	0	0	0	0	1	0	0	0	10302	1299	45	5	2118	5	NEB	2	152363440	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08	76642907	152363440	90835933	10	14925											
COL6A3	1293	broad.mit.edu	37	chr2	238275426	238275426	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagttcggacagctcctggaCgttgcccacgcggaacgctg	13	14	0	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr2:238275426C>T	uc002vwl.2	-	11	5689	c.5404G>A	c.(5404-5406)GTC>ATC	p.V1802I	COL6A3_uc002vwo.2_Missense_Mutation_p.V1596I|COL6A3_uc010znj.1_Missense_Mutation_p.V1195I	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1802	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGCTCCTGGACGTTGCCCACG	0.532													T	238275426	T	T	238275426	3	4	212	1	0	0	0	0	1	0	0	0	3701	536	19	1	4265	1	COL6A3	2	238275426	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08	85911986	238275426	4923947	11	14926											
TRAIP	10293	broad.mit.edu	37	chr3	49869443	49869443	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	atcaaaggtagcattgagatCaatatcatcacggaaggatg	10	6	4	1			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr3:49869443C>A	uc003cxs.1	-	11	1049	c.943G>T	c.(943-945)GAT>TAT	p.D315Y	TRAIP_uc010hla.1_Missense_Mutation_p.D216Y	NM_005879	NP_005870	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	315	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCATTGAGATCAATATCATCA	0.542													A	49869443	A	A	49869443	3	1	212	1	0	0	0	0	1	0	0	0	16445	826	29	5	486	5	TRAIP	3	49869443	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08		49869443	148152987	12	14927											
TLR6	10333	broad.mit.edu	37	chr4	38830190	38830190	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtcaatgctttcaatgtcGttttagaataagtaaaatct	6	5	3	1			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr4:38830190G>A	uc003gtm.2	-	1	971	c.905C>T	c.(904-906)ACG>ATG	p.T302M	TLR6_uc010ifg.1_Missense_Mutation_p.T302M	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	302	Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						TTTCAATGTCGTTTTAGAATA	0.323													A	38830190	A	A	38830190	3	1	212	1	0	0	0	0	1	0	0	0	15952	1145	40	1	1489	1	TLR6	4	38830190	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08		38830190	152324086	13	14928											
TNIP3	79931	broad.mit.edu	37	chr4	122085228	122085228	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcttacctctttatgctccGtagaactttctgcggcaatc	6	12	3	1	rs144762502	byFrequency	TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr4:122085228G>A	uc010ing.2	-	1	249	c.53C>T	c.(52-54)ACG>ATG	p.T18M	TNIP3_uc010inh.2_Missense_Mutation_p.T18M|TNIP3_uc011cgj.1_Missense_Mutation_p.T76M|TNIP3_uc010ini.2_Missense_Mutation_p.T18M	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	18										ovary(1)	1						TTTATGCTCCGTAGAACTTTC	0.398													A	122085228	A	A	122085228	3	1	212	1	0	0	0	0	1	0	0	0	16313	1145	40	1	968	1	TNIP3	4	122085228	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08	83255038	122085228	69069048	14	14929											
HCN1	348980	broad.mit.edu	37	chr5	45695952	45695952	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccggggcccctcggcgtcttCgaagccccccgccggctcct	12	21	1	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr5:45695952C>T	uc003jok.2	-	1	269	c.244G>A	c.(244-246)GAA>AAA	p.E82K		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	82	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TCGGCGTCTTCGAAGCCCCCC	0.478													T	45695952	T	T	45695952	3	4	212	1	0	0	0	0	1	0	0	0	6996	893	31	2	2460	2	HCN1	5	45695952	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08		45695952	135219308	15	14930											
ZNF366	167465	broad.mit.edu	37	chr5	71757119	71757120	+	Missense_Mutation	DNP	CG	AT	AT													ccctgctccttcgaagacccCggggaacccatctaggtctc							TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr5:71757119_71757120CG>AT	uc003kce.1	-	2	390_391	c.204_205CG>AT	c.(202-207)CCCGGG>CCATGG	p.G69W		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	69					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		TCGAAGACCCCGGGGAACCCAT	0.584													AT	71757120	AT	AT	71757119	3	1	212	1	0	0	0	0	1	0	0	0	17867	652	23	5	2045	5	ZNF366	5	71757119	Missense_Mutation	DNP	CG	TCGA-28-5211-01C-11D-1845-08	26061167	71757119	109158141	16	14931											
E2F3	1871	broad.mit.edu	37	chr6	20402625	20402625	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gccgccgctgccgccgccccGggcgcgtacatccagatcct	12	20	0	1			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr6:20402625G>C	uc003nda.2	+	1	489	c.162G>C	c.(160-162)CCG>CCC	p.P54P	E2F3_uc003ncz.2_Silent_p.P54P	NM_001949	NP_001940	O00716	E2F3_HUMAN	E2F transcription factor 3	54					G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)			ccgccgccCCGGGCGCGTACA	0.597													C	20402625	C	C	20402625	2	2	212	1	0	0	0	0	0	0	0	1	4868	1103	39	5		5	E2F3	6	20402625	Silent	SNP	G	TCGA-28-5211-01C-11D-1845-08		20402625	150712442	17	14932											
BAT2	7916	broad.mit.edu	37	chr6	31599728	31599728	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gacacggagcgagggttcagAgtatgaggaaatccccaagc	14	9	1	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr6:31599728A>G	uc003nvb.3	+	16	3527	c.3278A>G	c.(3277-3279)GAG>GGG	p.E1093G	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.E1093G	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1093	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						GAGGGTTCAGAGTATGAGGAA	0.632													G	31599728	G	G	31599728	3	3	212	1	0	0	0	0	1	0	0	0	1319	304	11	4	3336	4	BAT2	6	31599728	Missense_Mutation	SNP	A	TCGA-28-5211-01C-11D-1845-08	11197103	31599728	139515339	18	14933											
LAMA2	3908	broad.mit.edu	37	chr6	129802525	129802525	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	agaatgagtccggcatcattCttttgggaagtggagggaca	14	6	2	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr6:129802525C>G	uc003qbn.2	+	54	7795	c.7690C>G	c.(7690-7692)CTT>GTT	p.L2564V	LAMA2_uc003qbo.2_Missense_Mutation_p.L2560V|uc003qbq.2_RNA	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2564	Laminin G-like 3.		L -> P (in MDC1A).		cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CGGCATCATTCTTTTGGGAAG	0.488													G	129802525	G	G	129802525	3	3	212	1	0	0	0	0	1	0	0	0	8606	913	32	5	7908	5	LAMA2	6	129802525	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08	98202797	129802525	41312542	19	14934											
SYNE1	23345	broad.mit.edu	37	chr6	152861113	152861113	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	accttggccagatgagagttGatccattttgtgaaagttcg	11	7	0	4			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr6:152861113G>C	uc010kiw.2	-	4	713	c.111C>G	c.(109-111)ATC>ATG	p.I37M	SYNE1_uc003qot.3_Missense_Mutation_p.I37M|SYNE1_uc003qou.3_Missense_Mutation_p.I37M|SYNE1_uc010kjb.1_Missense_Mutation_p.I37M|SYNE1_uc003qpa.1_Missense_Mutation_p.I37M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	37	Actin-binding.|Cytoplasmic (Potential).|CH 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GATGAGAGTTGATCCATTTTG	0.338										HNSCC(10;0.0054)			C	152861113	C	C	152861113	3	2	212	1	0	0	0	0	1	0	0	0	15442	1280	45	5	26952	5	SYNE1	6	152861113	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08	23058588	152861113	18253954	20	14935											
GRB10	2887	broad.mit.edu	37	chr7	50674041	50674041	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctttacttaccactggcGtcgagaacggggacagcaag	13	10	0	1			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr7:50674041G>A	uc003tpi.2	-	11	1296	c.1265C>T	c.(1264-1266)ACG>ATG	p.T422M	GRB10_uc003tph.3_Missense_Mutation_p.T364M|GRB10_uc003tpj.2_Missense_Mutation_p.T376M|GRB10_uc003tpk.2_Missense_Mutation_p.T422M|GRB10_uc010kzb.2_Missense_Mutation_p.T364M|GRB10_uc003tpl.2_Missense_Mutation_p.T416M|GRB10_uc003tpm.2_Missense_Mutation_p.T364M|GRB10_uc003tpn.2_Missense_Mutation_p.T364M	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	422					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					TACCACTGGCGTCGAGAACGG	0.517									Russell-Silver_syndrome				A	50674041	A	A	50674041	3	1	212	1	0	0	0	0	1	0	0	0	6756	1145	40	1	543	1	GRB10	7	50674041	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08		50674041	108464622	21	14936											
DLC1	10395	broad.mit.edu	37	chr8	12957581	12957581	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcctcgtaacagggctgggCgtgctgaccgcgctgctggt	16	12	0	1	rs138749997	byFrequency	TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr8:12957581C>T	uc003wwm.2	-	9	2709	c.2265G>A	c.(2263-2265)ACG>ACA	p.T755T	DLC1_uc003wwk.1_Silent_p.T318T|DLC1_uc003wwl.1_Silent_p.T352T|DLC1_uc011kxx.1_Silent_p.T244T	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	755					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CAGGGCTGGGCGTGCTGACCG	0.582													T	12957581	T	T	12957581	2	4	212	1	0	0	0	0	0	0	0	1	4550	755	27	1		1	DLC1	8	12957581	Silent	SNP	C	TCGA-28-5211-01C-11D-1845-08		12957581	133406441	22	14937											
SEMA4D	10507	broad.mit.edu	37	chr9	92003832	92003832	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acacaggcaccttcaggcccGgggacctgagcacgaagaca	12	14	1	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr9:92003832G>T	uc004aqo.1	-	12	1477	c.905C>A	c.(904-906)CCG>CAG	p.P302Q	SEMA4D_uc011ltm.1_Missense_Mutation_p.P302Q|SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aqp.1_Missense_Mutation_p.P300Q	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	302	Sema.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						CTTCAGGCCCGGGGACCTGAG	0.602													T	92003832	T	T	92003832	3	4	212	1	0	0	0	0	1	0	0	0	14034	1116	39	5	2281	5	SEMA4D	9	92003832	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08		92003832	49209599	23	14938											
ST6GALNAC4	27090	broad.mit.edu	37	chr9	130670779	130670779	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggcgcttcggggcgcctgCtcgtgtgccaggtacatctg	16	12	1	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr9:130670779C>T	uc004bss.2	-	6	1077	c.801G>A	c.(799-801)GAG>GAA	p.E267E	ST6GALNAC4_uc004bst.2_Silent_p.E183E	NM_175039	NP_778204	Q9H4F1	SIA7D_HUMAN	sialyltransferase 7D isoform a	267	Lumenal (Potential).				glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity				0						GGGGCGCCTGCTCGTGTGCCA	0.627													T	130670779	T	T	130670779	2	4	212	1	0	0	0	0	0	0	0	1	15225	796	28	3		3	ST6GALNAC4	9	130670779	Silent	SNP	C	TCGA-28-5211-01C-11D-1845-08	38666947	130670779	10542652	24	14939											
PKN3	29941	broad.mit.edu	37	chr9	131476566	131476566	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcccccctgcagctcccCgagcacaatcagccccccta	7	22	1	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr9:131476566C>T	uc004bvw.2	+	11	1796	c.1403C>T	c.(1402-1404)CCG>CTG	p.P468L	PKN3_uc010myh.2_Missense_Mutation_p.P468L|PKN3_uc011mbk.1_Missense_Mutation_p.P18L	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	protein kinase PKNbeta	468	Pro-rich.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			stomach(2)|lung(2)	4						TGCAGCTCCCCGAGCACAATC	0.652													T	131476566	T	T	131476566	3	4	212	1	0	0	0	0	1	0	0	0	11981	652	23	2	1445	2	PKN3	9	131476566	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08	805787	131476566	9736865	25	14940											
BMI1	648	broad.mit.edu	37	chr10	22615480	22615480	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccacaaccataatagaatgTctacattcctgtaagtaccg	6	11	1	1			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr10:22615480T>G	uc001irh.2	+	2	741	c.102T>G	c.(100-102)TGT>TGG	p.C34W	BMI1_uc009xkg.2_Missense_Mutation_p.C177W	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	34	RING-type.				hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						TAATAGAATGTCTACATTCCT	0.413													G	22615480	G	G	22615480	3	3	212	1	0	0	0	0	1	0	0	0	1455	1673	58	5	104	5	BMI1	10	22615480	Missense_Mutation	SNP	T	TCGA-28-5211-01C-11D-1845-08		22615480	112919267	26	14941											
WDR11	55717	broad.mit.edu	37	chr10	122622305	122622305	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccccatccaagcctccctcAggccctgggaaaaaagttta	7	15	1	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr10:122622305A>G	uc010qtf.1	+	5	823	c.585A>G	c.(583-585)TCA>TCG	p.S195S	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	195						integral to membrane					0						AGCCTCCCTCAGGCCCTGGGA	0.443													G	122622305	G	G	122622305	2	3	212	1	0	0	0	0	0	0	0	1	17270	175	7	4		4	WDR11	10	122622305	Silent	SNP	A	TCGA-28-5211-01C-11D-1845-08	100006825	122622305	12912442	27	14942											
CDON	50937	broad.mit.edu	37	chr11	125853903	125853903	+	Frame_Shift_Del	DEL	C	-	-													ctggcagggctggttgcaggCcccacatttcctccacttcc					rs139149075		TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr11:125853903delC	uc009zbw.2	-	16	2987	c.2859delG	c.(2857-2859)GGGfs	p.G953fs	CDON_uc001qdb.3_Frame_Shift_Del_p.G330fs|CDON_uc001qdc.3_Frame_Shift_Del_p.G953fs	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	953	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TGGTTGCAGGCCCCACATTTC	0.463													-	125853903	-	-	125853903	7	5	212	1	0	1	0	1	0	0	0	0	3170	726	26	0	955	0	CDON	11	125853903	Frame_Shift_Del	DEL	C	TCGA-28-5211-01C-11D-1845-08		125853903	9152613	28	14943											
LRP1	4035	broad.mit.edu	37	chr12	57603612	57603612	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagggggcctgagccacgccTctgacgtggtcctttaccat	12	14	1	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr12:57603612T>C	uc001snd.2	+	80	12866	c.12400T>C	c.(12400-12402)TCT>CCT	p.S4134P		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4134	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GAGCCACGCCTCTGACGTGGT	0.572													C	57603612	C	C	57603612	3	2	212	1	0	0	0	0	1	0	0	0	8951	1551	54	4	12718	4	LRP1	12	57603612	Missense_Mutation	SNP	T	TCGA-28-5211-01C-11D-1845-08		57603612	76248283	29	14944											
LUM	4060	broad.mit.edu	37	chr12	91498030	91498030	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatgcgattgccatccaaaCgcaaatgcttgatcttggag	10	9	1	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr12:91498030C>T	uc001tbm.2	-	3	1318	c.929G>A	c.(928-930)CGT>CAT	p.R310H	LUM_uc001tbn.2_RNA	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	310	LRR 11.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						GCCATCCAAACGCAAATGCTT	0.373													T	91498030	T	T	91498030	3	4	212	1	0	0	0	0	1	0	0	0	9085	536	19	1	91	1	LUM	12	91498030	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08	33894418	91498030	42353865	30	14945											
SYNE2	23224	broad.mit.edu	37	chr14	64497733	64497733	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caatcttttctccactcgtaGgaactagagaatagactcag	7	10	3	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr14:64497733G>A	uc001xgm.2	+	45	7110	c.6880_splice	c.e45-1	p.E2294_splice	SYNE2_uc001xgl.2_Splice_Site_p.E2294_splice	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2						centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCCACTCGTAGGAACTAGAGA	0.353													A	64497733	A	A	64497733	5	1	212	1	0	0	0	0	0	0	1	0	15443	1014	35	3	7053	3	SYNE2	14	64497733	Splice_Site	SNP	G	TCGA-28-5211-01C-11D-1845-08		64497733	42851807	31	14946											
GJD2	57369	broad.mit.edu	37	chr15	35045227	35045227	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcaacttcttatcttctcGtttgcccccaccactgcccc	4	18	3	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr15:35045227G>A	uc001zis.1	-	2	418	c.418C>T	c.(418-420)CGA>TGA	p.R140*	uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	140	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		TTATCTTCTCGTTTGCCCCCA	0.532													A	35045227	A	A	35045227	4	1	212	1	0	0	0	0	0	1	0	0	6417	1153	40	1	551	1	GJD2	15	35045227	Nonsense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08		35045227	67486165	32	14947											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84651232	84651232	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagtgggagaaggatggccGttgcctgcagaactccaaac	13	11	0	2	rs147113160		TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr15:84651232G>A	uc002bjz.3	+	21	3076	c.2852G>A	c.(2851-2853)CGT>CAT	p.R951H	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.R951H|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.R951H	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	951	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AAGGATGGCCGTTGCCTGCAG	0.532													A	84651232	A	A	84651232	3	1	212	1	0	0	0	0	1	0	0	0	276	1145	40	1	2930	1	ADAMTSL3	15	84651232	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08	49606005	84651232	17880160	33	14948											
MCTP2	55784	broad.mit.edu	37	chr15	94943189	94943189	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttttactccccgggaaaagCgctttgttgaagacagccgc	10	12	0	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr15:94943189C>T	uc002btj.2	+	15	1995	c.1930C>T	c.(1930-1932)CGC>TGC	p.R644C	MCTP2_uc010boj.2_Missense_Mutation_p.R373C|MCTP2_uc010bok.2_Missense_Mutation_p.R644C|MCTP2_uc002btk.3_Missense_Mutation_p.R232C|MCTP2_uc002btl.2_Missense_Mutation_p.R232C	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	644					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CCGGGAAAAGCGCTTTGTTGA	0.458													T	94943189	T	T	94943189	3	4	212	1	0	0	0	0	1	0	0	0	9401	768	27	1	1988	1	MCTP2	15	94943189	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08	10291957	94943189	7588203	34	14949											
ABCC6	368	broad.mit.edu	37	chr16	16272807	16272807	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagccgctgcttctggcctcCggagagattcatgccctgtg	12	14	2	1	rs72653787		TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr16:16272807C>T	uc002den.3	-	18	2300	c.2263G>A	c.(2263-2265)GGA>AGA	p.G755R	ABCC6_uc010bvo.2_RNA	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	755	ABC transporter 1.|Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TTCTGGCCTCCGGAGAGATTC	0.627													T	16272807	T	T	16272807	3	4	212	1	0	0	0	0	1	0	0	0	57	661	23	2	2304	2	ABCC6	16	16272807	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08		16272807	74081946	35	14950											
C16orf93	90835	broad.mit.edu	37	chr16	30770347	30770347	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cctcacttggctctggctctGgtggggccactgtctctagt	12	13	4	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr16:30770347G>C	uc002dzm.2	-	8	1134	c.803C>G	c.(802-804)CCA>CGA	p.P268R	C16orf93_uc002dzn.2_Missense_Mutation_p.P333R|C16orf93_uc002dzo.2_Missense_Mutation_p.P231R	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835	268											0						CTCTGGCTCTGGTGGGGCCAC	0.522													C	30770347	C	C	30770347	3	2	212	1	0	0	0	0	1	0	0	0	1846	1348	47	5	200	5	C16orf93	16	30770347	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08	14497540	30770347	59584406	36	14951											
MYH10	4628	broad.mit.edu	37	chr17	8390908	8390908	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccagctccgcctcgagctccCgcacctaatggacaacatcg	8	18	0	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr17:8390908C>A	uc002gll.2	-	34	4892	c.4796G>T	c.(4795-4797)CGG>CTG	p.R1599L	MYH10_uc002glm.2_Missense_Mutation_p.R1630L|MYH10_uc010cnx.2_Missense_Mutation_p.R1608L	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1599	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CTCGAGCTCCCGCACCTAATG	0.542													A	8390908	A	A	8390908	3	1	212	1	0	0	0	0	1	0	0	0	10030	652	23	5	1166	5	MYH10	17	8390908	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08		8390908	72804302	37	14952											
GLP2R	9340	broad.mit.edu	37	chr17	9792806	9792806	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaatgtcccaagaagctctcGgaaggagatggcgctgagaa	13	8	1	3			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr17:9792806G>A	uc002gmd.1	+	13	1446	c.1446G>A	c.(1444-1446)TCG>TCA	p.S482S		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	482	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	AGAAGCTCTCGGAAGGAGATG	0.597													A	9792806	A	A	9792806	2	1	212	1	0	0	0	0	0	0	0	1	6453	1103	39	2		2	GLP2R	17	9792806	Silent	SNP	G	TCGA-28-5211-01C-11D-1845-08	1401898	9792806	71402404	38	14953											
KRT35	3886	broad.mit.edu	37	chr17	39633981	39633981	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctctgccagggtggattccaAagcatctctctgtgagggca	12	11	3	1			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr17:39633981A>G	uc002hws.2	-	6	1052	c.1009T>C	c.(1009-1011)TTG>CTG	p.L337L		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	337	Rod.|Coil 2.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				GTGGATTCCAAAGCATCTCTC	0.577													G	39633981	G	G	39633981	2	3	212	1	0	0	0	0	0	0	0	1	8472	11	1	4		4	KRT35	17	39633981	Silent	SNP	A	TCGA-28-5211-01C-11D-1845-08	29841175	39633981	41561229	39	14954											
ENGASE	64772	broad.mit.edu	37	chr17	77073856	77073856	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggctttaatgtggccctggAgcccctggcgtgtcgccagc	14	13	0	0			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr17:77073856A>G	uc002jwv.2	+	3	334	c.326A>G	c.(325-327)GAG>GGG	p.E109G	ENGASE_uc002jwu.1_Missense_Mutation_p.E109G|ENGASE_uc010wtz.1_5'UTR|ENGASE_uc002jww.2_5'Flank	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	109						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						GTGGCCCTGGAGCCCCTGGCG	0.592													G	77073856	G	G	77073856	3	3	212	1	0	0	0	0	1	0	0	0	5118	304	11	4	336	4	ENGASE	17	77073856	Missense_Mutation	SNP	A	TCGA-28-5211-01C-11D-1845-08	37439875	77073856	4121354	40	14955											
SLC1A6	6511	broad.mit.edu	37	chr19	15067457	15067457	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccagctgaccccccaggaCggccatgtcttccatctcca	8	19	2	1			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr19:15067457C>T	uc002naa.1	-	6	1008	c.1000G>A	c.(1000-1002)GTC>ATC	p.V334I	SLC1A6_uc010dzu.1_Intron|SLC1A6_uc010xod.1_Missense_Mutation_p.V270I	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	334					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity	p.V334I(1)		pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	CCCCCCAGGACGGCCATGTCT	0.582													T	15067457	T	T	15067457	3	4	212	1	0	0	0	0	1	0	0	0	14436	536	19	1	710	1	SLC1A6	19	15067457	Missense_Mutation	SNP	C	TCGA-28-5211-01C-11D-1845-08		15067457	44061526	41	14956											
PTPRH	5794	broad.mit.edu	37	chr19	55698964	55698964	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actggctgtggcccaccaggGagagttgctggggatgcagg	18	9	0	1			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chr19:55698964G>A	uc002qjq.2	-	14	2556	c.2483C>T	c.(2482-2484)TCC>TTC	p.S828F	PTPRH_uc010esv.2_Missense_Mutation_p.S650F|uc002qjr.2_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	828	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GCCCACCAGGGAGAGTTGCTG	0.587													A	55698964	A	A	55698964	3	1	212	1	0	0	0	0	1	0	0	0	12803	1174	41	3	892	3	PTPRH	19	55698964	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08	40631507	55698964	3430019	42	14957											
ARHGAP6	395	broad.mit.edu	37	chrX	11682473	11682473	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgccattggggcctcccccgGatgaacagaggatgctggaa	14	11	0	2			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chrX:11682473G>A	uc004cup.1	-	1	1349	c.476C>T	c.(475-477)TCC>TTC	p.S159F	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.S159F	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	159					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						GCCTCCCCCGGATGAACAGAG	0.657													A	11682473	A	A	11682473	3	1	212	1	0	0	0	0	1	0	0	0	887	1174	41	3	2622	3	ARHGAP6	23	11682473	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08		11682473	143588087	43	14958											
MAGEC2	51438	broad.mit.edu	37	chrX	141291609	141291609	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atcagagaagaggatgtggaGaaagaagagggggaaaatac	16	2	1	5			TCGA-28-5211-01C-11D-1845-08	TCGA-28-5211-10B-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f8dc846b-1b17-4699-9dc5-3f79e21eee94	fb345933-459e-4ab9-b876-7b07b709d6fe	g.chrX:141291609G>T	uc004fbu.1	-	3	513	c.165C>A	c.(163-165)TTC>TTA	p.F55L		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	55	Ser-rich.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AGGATGTGGAGAAAGAAGAGG	0.483										HNSCC(46;0.14)			T	141291609	T	T	141291609	3	4	212	1	0	0	0	0	1	0	0	0	9181	933	33	5	960	5	MAGEC2	23	141291609	Missense_Mutation	SNP	G	TCGA-28-5211-01C-11D-1845-08	129609136	141291609	13978951	44	14959											
TAS1R1	80835	broad.mit.edu	37	chr1	6634905	6634905	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccactggtcaggggatctGcattgctttcaaggacatca	12	10	4	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:6634905G>A	uc001ant.2	+	3	713	c.713G>A	c.(712-714)TGC>TAC	p.C238Y	TAS1R1_uc001anu.2_Intron|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_Missense_Mutation_p.C238Y	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	238	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CAGGGGATCTGCATTGCTTTC	0.622													A	6634905	A	A	6634905	3	1	213	1	0	0	0	0	1	0	0	0	15559	1319	46	3	723	3	TAS1R1	1	6634905	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08		6634905	242615716	1	14960											
KLHDC7A	127707	broad.mit.edu	37	chr1	18808936	18808936	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagctgatcctgcagcgccgGctccggggccgccagtacct	14	16	0	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:18808936G>A	uc001bax.2	+	1	1513	c.1461G>A	c.(1459-1461)CGG>CGA	p.R487R	KLHDC7A_uc009vpg.2_Silent_p.R269R	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	487						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGCAGCGCCGGCTCCGGGGCC	0.662													A	18808936	A	A	18808936	2	1	213	1	0	0	0	0	0	0	0	1	8360	1190	42	3		3	KLHDC7A	1	18808936	Silent	SNP	G	TCGA-28-5213-01A-01D-1486-08	12174031	18808936	230441685	2	14961											
RSPO1	284654	broad.mit.edu	37	chr1	38079485	38079485	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accctgcgtgtccgctcctcGgagcccctccggaaaccaca	9	19	0	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:38079485G>A	uc001cbl.1	-	7	1304	c.516C>T	c.(514-516)TCC>TCT	p.S172S	RSPO1_uc001cbm.1_Silent_p.S172S|RSPO1_uc009vvf.1_Silent_p.S145S|RSPO1_uc009vvg.1_Intron	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	172	TSP type-1.				positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCCGCTCCTCGGAGCCCCTCC	0.632													A	38079485	A	A	38079485	2	1	213	1	0	0	0	0	0	0	0	1	13709	1103	39	2		2	RSPO1	1	38079485	Silent	SNP	G	TCGA-28-5213-01A-01D-1486-08	19270549	38079485	211171136	3	14962											
MACF1	23499	broad.mit.edu	37	chr1	39799225	39799225	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattgtgccaagtcacactgCcgtgaagcttatggagaagc	11	10	1	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:39799225C>T	uc010oiu.1	+	1	2416	c.2285C>T	c.(2284-2286)GCC>GTC	p.A762V	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2327	Plectin 6.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGTCACACTGCCGTGAAGCTT	0.423													T	39799225	T	T	39799225	3	4	213	1	0	0	0	0	1	0	0	0	9144	739	26	3	7056	3	MACF1	1	39799225	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	1719740	39799225	209451396	4	14963											
MOBKL2C	148932	broad.mit.edu	37	chr1	47078629	47078629	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaggccttcgatccagtccAtgagcaatgccatatagcgc	10	12	0	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:47078629A>G	uc001cqf.3	-	2	596	c.365T>C	c.(364-366)ATG>ACG	p.M122T	MKNK1_uc010omf.1_Intron|MOBKL2C_uc001cqe.3_Missense_Mutation_p.M174T	NM_201403	NP_958805	Q70IA8	MOL2C_HUMAN	MOB1, Mps One Binder kinase activator-like 2C	122							metal ion binding			pancreas(1)	1	Acute lymphoblastic leukemia(166;0.155)					GATCCAGTCCATGAGCAATGC	0.637													G	47078629	G	G	47078629	3	3	213	1	0	0	0	0	1	0	0	0	9686	217	8	4	297	4	MOBKL2C	1	47078629	Missense_Mutation	SNP	A	TCGA-28-5213-01A-01D-1486-08	7279404	47078629	202171992	5	14964											
C1orf177	163747	broad.mit.edu	37	chr1	55273665	55273665	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcagctctggggaggttcGcttccgaggactcactgggg	16	11	3	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:55273665G>A	uc001cyb.3	+	4	515	c.461G>A	c.(460-462)CGC>CAC	p.R154H	C1orf177_uc001cya.3_Missense_Mutation_p.R154H	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	154											0						GGGGAGGTTCGCTTCCGAGGA	0.413													A	55273665	A	A	55273665	3	1	213	1	0	0	0	0	1	0	0	0	2017	1087	38	1	475	1	C1orf177	1	55273665	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	8195036	55273665	193976956	6	14965											
INADL	10207	broad.mit.edu	37	chr1	62253476	62253476	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaagattggtggcacaaaCgtgcagggaatgaccagtga	14	6	0	4			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:62253476C>T	uc001dab.2	+	8	1014	c.900C>T	c.(898-900)AAC>AAT	p.N300N	INADL_uc009waf.1_Silent_p.N300N|INADL_uc001daa.2_Silent_p.N300N|INADL_uc001dad.3_Translation_Start_Site	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	300	PDZ 2.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						GTGGCACAAACGTGCAGGGAA	0.438													T	62253476	T	T	62253476	2	4	213	1	0	0	0	0	0	0	0	1	7731	535	19	1		1	INADL	1	62253476	Silent	SNP	C	TCGA-28-5213-01A-01D-1486-08	6979811	62253476	186997145	7	14966											
TRIM45	80263	broad.mit.edu	37	chr1	117663350	117663350	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttacctatgagcctggcaGcagaagtggcagaggttggc	14	9	0	3			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:117663350G>A	uc001egz.2	-	1	1062	c.474C>T	c.(472-474)TGC>TGT	p.C158C	TRIM45_uc009whe.2_Silent_p.C158C|TRIM45_uc001eha.2_Silent_p.C54C	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	158	B box-type 1.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		GAGCCTGGCAGCAGAAGTGGC	0.527													A	117663350	A	A	117663350	2	1	213	1	0	0	0	0	0	0	0	1	16517	963	34	3		3	TRIM45	1	117663350	Silent	SNP	G	TCGA-28-5213-01A-01D-1486-08	55409874	117663350	131587271	8	14967											
TCHH	7062	broad.mit.edu	37	chr1	152083970	152083970	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcttcagcagctgatcgcGcctctcctcctgctcgcgct	10	18	2	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:152083970G>A	uc001ezp.2	-	2	1723	c.1723C>T	c.(1723-1725)CGC>TGC	p.R575C	TCHH_uc009wne.1_Missense_Mutation_p.R575C	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	575	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGATCGCGCCTCTCCTCC	0.677													A	152083970	A	A	152083970	3	1	213	1	0	0	0	0	1	0	0	0	15697	1087	38	1	4112	1	TCHH	1	152083970	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	34420620	152083970	97166651	9	14968											
SPTA1	6708	broad.mit.edu	37	chr1	158606471	158606471	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccagctccccctctaggCgtttgtgcttcttcagcaag	8	16	3	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:158606471C>T	uc001fst.1	-	37	5469	c.5270G>A	c.(5269-5271)CGC>CAC	p.R1757H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1757	Spectrin 17.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCCCTCTAGGCGTTTGTGCTT	0.383													T	158606471	T	T	158606471	3	4	213	1	0	0	0	0	1	0	0	0	15115	768	27	1	2053	1	SPTA1	1	158606471	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	6522501	158606471	90644150	10	14969											
PYHIN1	149628	broad.mit.edu	37	chr1	158906881	158906881	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaagttcccaggtgatgccGgtttgggcaaactaatagaa	11	7	0	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:158906881G>A	uc001ftb.2	+	2	426	c.181G>A	c.(181-183)GGT>AGT	p.G61S	PYHIN1_uc001fta.3_Missense_Mutation_p.G61S|PYHIN1_uc001ftc.2_Missense_Mutation_p.G61S|PYHIN1_uc001ftd.2_Missense_Mutation_p.G61S|PYHIN1_uc001fte.2_Missense_Mutation_p.G61S	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	61	DAPIN.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					AGGTGATGCCGGTTTGGGCAA	0.368													A	158906881	A	A	158906881	3	1	213	1	0	0	0	0	1	0	0	0	12865	1116	39	2	183	2	PYHIN1	1	158906881	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	300410	158906881	90343740	11	14970											
IGFN1	91156	broad.mit.edu	37	chr1	201195009	201195009	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacgtgcctgggacggtgaCggccgagtgggaaccctctc	16	12	1	1	rs145852390		TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:201195009C>T	uc001gwc.2	+	11	2796	c.2024C>T	c.(2023-2025)ACG>ATG	p.T675M	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						GGGACGGTGACGGCCGAGTGG	0.687													T	201195009	T	T	201195009	3	4	213	1	0	0	0	0	1	0	0	0	7590	536	19	1	10626	1	IGFN1	1	201195009	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	42288128	201195009	48055612	12	14971											
OR2T33	391195	broad.mit.edu	37	chr1	248436203	248436203	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgttttatgtttacacacGtccccagccaccgtttcagg	9	12	1	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr1:248436203G>A	uc010pzi.1	-	1	914	c.914C>T	c.(913-915)ACG>ATG	p.T305M		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTTTACACACGTCCCCAGCCA	0.423													A	248436203	A	A	248436203	3	1	213	1	0	0	0	0	1	0	0	0	11024	1145	40	1	51	1	OR2T33	1	248436203	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	47241194	248436203	814418	13	14972											
CCDC85A	114800	broad.mit.edu	37	chr2	56603032	56603032	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttcagtggacatgccacaCcttcccagcagcctgaacct	8	16	1	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr2:56603032C>T	uc002rzn.2	+	5	2036	c.1534C>T	c.(1534-1536)CCT>TCT	p.P512S		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	512										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACATGCCACACCTTCCCAGCA	0.473													T	56603032	T	T	56603032	3	4	213	1	0	0	0	0	1	0	0	0	2859	507	18	3	1552	3	CCDC85A	2	56603032	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08		56603032	186596341	14	14973											
POLR1B	84172	broad.mit.edu	37	chr2	113315616	113315616	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcatagaccttacaaaaccaTttgaatacctttttgctact	4	10	0	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr2:113315616T>C	uc002thw.2	+	8	1868	c.1288T>C	c.(1288-1290)TTT>CTT	p.F430L	POLR1B_uc010fkn.2_Missense_Mutation_p.F374L|POLR1B_uc002thx.2_Missense_Mutation_p.F291L|POLR1B_uc010fko.2_Intron|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Missense_Mutation_p.F468L|POLR1B_uc002thy.2_Missense_Mutation_p.F291L|POLR1B_uc010yxo.1_Missense_Mutation_p.F207L	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	430					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						TACAAAACCATTTGAATACCT	0.328													C	113315616	C	C	113315616	3	2	213	1	0	0	0	0	1	0	0	0	12210	1493	52	4	1318	4	POLR1B	2	113315616	Missense_Mutation	SNP	T	TCGA-28-5213-01A-01D-1486-08	56712584	113315616	129883757	15	14974											
TTN	7273	broad.mit.edu	37	chr2	179410767	179410767	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgctcctccgtcttcctgCggaaggctccaggctaaagt	10	14	2	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr2:179410767C>T	uc010zfg.1	-	292	87716	c.87492G>A	c.(87490-87492)CCG>CCA	p.P29164P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.P22859P|TTN_uc010zfi.1_Silent_p.P22792P|TTN_uc010zfj.1_Silent_p.P22667P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30091							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGTCTTCCTGCGGAAGGCTCC	0.527													T	179410767	T	T	179410767	2	4	213	1	0	0	0	0	0	0	0	1	16732	755	27	1		1	TTN	2	179410767	Silent	SNP	C	TCGA-28-5213-01A-01D-1486-08	66095151	179410767	63788606	16	14975											
CRYGC	1420	broad.mit.edu	37	chr2	208993026	208993026	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggggcctcagcaggtattgCcgcccccggtagttgggcag	16	12	1	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr2:208993026C>T	uc002vco.3	-	3	464	c.426G>A	c.(424-426)CGG>CGA	p.R142R		NM_020989	NP_066269	P07315	CRGC_HUMAN	crystallin, gamma C	142	Beta/gamma crystallin 'Greek key' 4.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		GCAGGTATTGCCGCCCCCGGT	0.622													T	208993026	T	T	208993026	2	4	213	1	0	0	0	0	0	0	0	1	3916	726	26	3		3	CRYGC	2	208993026	Silent	SNP	C	TCGA-28-5213-01A-01D-1486-08	29582259	208993026	34206347	17	14976											
PNKD	25953	broad.mit.edu	37	chr2	219206751	219206751	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtgggacggcttcagatccGggccctggctacacctggcc	14	15	1	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr2:219206751G>A	uc002vhn.2	+	7	809	c.665G>A	c.(664-666)CGG>CAG	p.R222Q	PNKD_uc002vhq.2_Missense_Mutation_p.R198Q	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	222						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTTCAGATCCGGGCCCTGGCT	0.597													A	219206751	A	A	219206751	3	1	213	1	0	0	0	0	1	0	0	0	12146	1116	39	2	1056	2	PNKD	2	219206751	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	10213725	219206751	23992622	18	14977											
SGOL1	151648	broad.mit.edu	37	chr3	20225255	20225255	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caaagctaaaactaacatttTgttgttgtcttggtaatttt	6	5	1	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr3:20225255T>C	uc003cbs.2	-	3	371	c.184A>G	c.(184-186)AAA>GAA	p.K62E	SGOL1_uc003cbr.2_Missense_Mutation_p.K62E|SGOL1_uc010hfa.2_Missense_Mutation_p.K62E|SGOL1_uc003cbt.2_Missense_Mutation_p.K62E|SGOL1_uc003cbu.2_Missense_Mutation_p.K62E|SGOL1_uc003cbv.2_Missense_Mutation_p.K62E|SGOL1_uc003cbw.2_Missense_Mutation_p.K62E|SGOL1_uc003cbx.2_Missense_Mutation_p.K62E|SGOL1_uc003cby.2_Missense_Mutation_p.K62E|SGOL1_uc003cbz.2_Missense_Mutation_p.K62E|SGOL1_uc003cca.2_Missense_Mutation_p.K62E|SGOL1_uc003ccb.2_Missense_Mutation_p.K62E|SGOL1_uc003ccc.2_Missense_Mutation_p.K62E	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	62	Potential.|Necessary for interaction with PPP2CA and PPP2R1A.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0						ACTAACATTTTGTTGTTGTCT	0.294													C	20225255	C	C	20225255	3	2	213	1	0	0	0	0	1	0	0	0	14216	1821	63	4	1549	4	SGOL1	3	20225255	Missense_Mutation	SNP	T	TCGA-28-5213-01A-01D-1486-08		20225255	177797175	19	14978											
MAPKAPK3	7867	broad.mit.edu	37	chr3	50655078	50655078	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gacccggcttgggcggtgctCcgggggggcggcgggagccc	22	13	0	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr3:50655078C>T	uc003day.1	+	4	678	c.82C>T	c.(82-84)CCG>TCG	p.P28S	MAPKAPK3_uc003daz.1_Missense_Mutation_p.P28S|MAPKAPK3_uc003dba.1_Missense_Mutation_p.P28S|MAPKAPK3_uc010hlr.1_Missense_Mutation_p.P28S	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	28			P -> S (in a glioblastoma multiforme sample; somatic mutation).		activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity	p.P28S(1)		ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		GGGCGGTGCTCCGGGGGGGCG	0.697													T	50655078	T	T	50655078	3	4	213	1	0	0	0	0	1	0	0	0	9290	855	30	3	84	3	MAPKAPK3	3	50655078	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	30429823	50655078	147367352	20	14979											
CASR	846	broad.mit.edu	37	chr3	122003457	122003457	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgctttcaaggtggctgccCgggccacgctgcgccgcagc	14	16	1	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr3:122003457C>T	uc003eev.3	+	7	3028	c.2656C>T	c.(2656-2658)CGG>TGG	p.R886W	CASR_uc003eew.3_Missense_Mutation_p.R896W	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	886	Cytoplasmic (Potential).|Interaction with RNF19A.		R -> W (could be associated with FHH).		anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GGTGGCTGCCCGGGCCACGCT	0.612													T	122003457	T	T	122003457	3	4	213	1	0	0	0	0	1	0	0	0	2682	643	23	2	2708	2	CASR	3	122003457	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	71348379	122003457	76018973	21	14980											
GHSR	2693	broad.mit.edu	37	chr3	172165482	172165482	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcatcgccgcgcctcctcCgccacagcttcctgccgatg	9	20	0	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr3:172165482C>T	uc003fib.1	-	1	722	c.722G>A	c.(721-723)CGG>CAG	p.R241Q	GHSR_uc011bpv.1_Missense_Mutation_p.R241Q	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	241	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GCGCCTCCTCCGCCACAGCTT	0.602													T	172165482	T	T	172165482	3	4	213	1	0	0	0	0	1	0	0	0	6375	652	23	2	460	2	GHSR	3	172165482	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	50162025	172165482	25856948	22	14981											
WDFY3	23001	broad.mit.edu	37	chr4	85634313	85634313	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaggaacaaaccacctaccCctgctccacactcgtgtttg	6	16	0	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr4:85634313C>T	uc003hpd.2	-	51	8449	c.8041G>A	c.(8041-8043)GGA>AGA	p.G2681R	WDFY3_uc003hpe.1_Missense_Mutation_p.G292R	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2681						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ACCACCTACCCCTGCTCCACA	0.398													T	85634313	T	T	85634313	3	4	213	1	0	0	0	0	1	0	0	0	17267	637	22	3	2611	3	WDFY3	4	85634313	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08		85634313	105519963	23	14982											
SLCO6A1	133482	broad.mit.edu	37	chr5	101834365	101834365	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttcctttttcggaaaccgcCgaaccttatcaaggcctctg	7	13	2	0	rs144293843		TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr5:101834365C>T	uc003knn.2	-	1	356	c.184G>A	c.(184-186)GGC>AGC	p.G62S	SLCO6A1_uc003kno.2_Missense_Mutation_p.G62S|SLCO6A1_uc003knp.2_Missense_Mutation_p.G62S|SLCO6A1_uc003knq.2_Missense_Mutation_p.G62S	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	62	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CGGAAACCGCCGAACCTTATC	0.537													T	101834365	T	T	101834365	3	4	213	1	0	0	0	0	1	0	0	0	14732	652	23	2	2027	2	SLCO6A1	5	101834365	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08		101834365	79080895	24	14983											
TFAP2B	7021	broad.mit.edu	37	chr6	50791291	50791291	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctaccaccagagccaggacCcctactcccacgtcaacgac	6	20	1	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr6:50791291C>T	uc003pag.2	+	2	419	c.253C>T	c.(253-255)CCC>TCC	p.P85S		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	85	Gln/Pro-rich (transactivation domain).				nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					GAGCCAGGACCCCTACTCCCA	0.682													T	50791291	T	T	50791291	3	4	213	1	0	0	0	0	1	0	0	0	15785	623	22	3	259	3	TFAP2B	6	50791291	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08		50791291	120323776	25	14984											
GJA10	84694	broad.mit.edu	37	chr6	90605129	90605129	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccaaggcaacttgaagtagaCccttccaatgggaaaaagga	10	9	0	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr6:90605129C>A	uc011eaa.1	+	1	942	c.942C>A	c.(940-942)GAC>GAA	p.D314E		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	314	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TTGAAGTAGACCCTTCCAATG	0.498													A	90605129	A	A	90605129	3	1	213	1	0	0	0	0	1	0	0	0	6401	506	18	5	944	5	GJA10	6	90605129	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	39813838	90605129	80509938	26	14985											
C7orf11	136647	broad.mit.edu	37	chr7	40172717	40172717	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtattgctgtattgttggcTtatatccactacagatactg	8	7	0	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr7:40172717T>C	uc003thl.3	-	2	573	c.481A>G	c.(481-483)AGC>GGC	p.S161G	C7orf10_uc003thm.1_5'Flank|C7orf10_uc003thn.1_5'Flank|C7orf10_uc003tho.1_5'Flank	NM_138701	NP_619646	Q8TAP9	TTDN1_HUMAN	chromosome 7 open reading frame 11	161					cell division|mitosis	microtubule organizing center|nucleus				breast(1)	1						TATTGTTGGCTTATATCCACT	0.363								Direct_reversal_of_damage|Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents					C	40172717	C	C	40172717	3	2	213	1	0	0	0	0	1	0	0	0	2377	1609	56	4	62	4	C7orf11	7	40172717	Missense_Mutation	SNP	T	TCGA-28-5213-01A-01D-1486-08		40172717	118965946	27	14986											
ADCY1	107	broad.mit.edu	37	chr7	45717835	45717835	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcctggctgccttatttgGccttgtctaccttctaatat	6	12	2	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr7:45717835G>A	uc003tne.3	+	10	1889	c.1871G>A	c.(1870-1872)GGC>GAC	p.G624D		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	624	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCCTTATTTGGCCTTGTCTAC	0.493													A	45717835	A	A	45717835	3	1	213	1	0	0	0	0	1	0	0	0	292	1203	42	3	1909	3	ADCY1	7	45717835	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	5545118	45717835	113420828	28	14987											
SUN3	256979	broad.mit.edu	37	chr7	48056901	48056901	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccatattctgcaattatggcAtataattgtctggatttctg	7	7	3	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr7:48056901A>G	uc003tof.2	-	4	343	c.246T>C	c.(244-246)TAT>TAC	p.Y82Y	SUN3_uc003tog.2_Silent_p.Y82Y|SUN3_uc011kcf.1_Silent_p.Y70Y	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	82						integral to membrane				central_nervous_system(1)	1						CAATTATGGCATATAATTGTC	0.299													G	48056901	G	G	48056901	2	3	213	1	0	0	0	0	0	0	0	1	15390	224	8	4		4	SUN3	7	48056901	Silent	SNP	A	TCGA-28-5213-01A-01D-1486-08	2339066	48056901	111081762	29	14988											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	213	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	7176142	55233043	103905620	30	14989											
TRPM3	80036	broad.mit.edu	37	chr9	73213424	73213424	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataccagtaaatgatgttcaCgcagtagatgaccctcccgt	8	11	1	3			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr9:73213424C>T	uc004aid.2	-	20	3167	c.2923G>A	c.(2923-2925)GTG>ATG	p.V975M	TRPM3_uc004ahu.2_Missense_Mutation_p.V805M|TRPM3_uc004ahv.2_Missense_Mutation_p.V777M|TRPM3_uc004ahw.2_Missense_Mutation_p.V847M|TRPM3_uc004ahx.2_Missense_Mutation_p.V834M|TRPM3_uc004ahy.2_Missense_Mutation_p.V837M|TRPM3_uc004ahz.2_Missense_Mutation_p.V824M|TRPM3_uc004aia.2_Missense_Mutation_p.V822M|TRPM3_uc004aib.2_Missense_Mutation_p.V812M|TRPM3_uc004aic.2_Missense_Mutation_p.V975M	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1000	Helical; (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						ATGATGTTCACGCAGTAGATG	0.483													T	73213424	T	T	73213424	3	4	213	1	0	0	0	0	1	0	0	0	16584	536	19	1	2224	1	TRPM3	9	73213424	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08		73213424	68000007	31	14990											
ERP44	23071	broad.mit.edu	37	chr9	102784454	102784454	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcatcatcatcccattaCgaaacaatttgagggttggg	8	9	4	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr9:102784454C>T	uc004bam.2	-	5	549	c.341G>A	c.(340-342)CGT>CAT	p.R114H	ERP44_uc010msy.2_RNA|ERP44_uc010msz.2_Missense_Mutation_p.R114H	NM_015051	NP_055866	Q9BS26	ERP44_HUMAN	thioredoxin domain containing 4 (endoplasmic	114	Thioredoxin.				cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity				0						CATCCCATTACGAAACAATTT	0.393													T	102784454	T	T	102784454	3	4	213	1	0	0	0	0	1	0	0	0	5243	536	19	1	911	1	ERP44	9	102784454	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	29571030	102784454	38428977	32	14991											
NEBL	10529	broad.mit.edu	37	chr10	21120216	21120216	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccctttaatttcattttctAagtccttcttgtattgtttc	3	9	3	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr10:21120216A>G	uc001iqi.2	-	16	1977	c.1580T>C	c.(1579-1581)TTA>TCA	p.L527S	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	527	Nebulin 14.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TTCATTTTCTAAGTCCTTCTT	0.353													G	21120216	G	G	21120216	3	3	213	1	0	0	0	0	1	0	0	0	10303	372	13	4	1516	4	NEBL	10	21120216	Missense_Mutation	SNP	A	TCGA-28-5213-01A-01D-1486-08		21120216	114414531	33	14992											
ADAM12	8038	broad.mit.edu	37	chr10	127755335	127755335	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgcacacagcgtccggcttcAgggtacaggtggtggcattg	15	11	1	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr10:127755335A>G	uc001ljk.2	-	13	1786	c.1373T>C	c.(1372-1374)CTG>CCG	p.L458P	ADAM12_uc010qul.1_Missense_Mutation_p.L409P|ADAM12_uc001ljm.2_Missense_Mutation_p.L458P|ADAM12_uc001ljn.2_Missense_Mutation_p.L455P|ADAM12_uc001ljl.3_Missense_Mutation_p.L455P	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	458	Extracellular (Potential).|Disintegrin.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GTCCGGCTTCAGGGTACAGGT	0.547													G	127755335	G	G	127755335	3	3	213	1	0	0	0	0	1	0	0	0	236	188	7	4	1508	4	ADAM12	10	127755335	Missense_Mutation	SNP	A	TCGA-28-5213-01A-01D-1486-08	106635119	127755335	7779412	34	14993											
MICAL2	9645	broad.mit.edu	37	chr11	12278418	12278418	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtgtgtacgtgatggaacgGctgagcgccgagggccactt	16	10	0	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr11:12278418G>A	uc001mjz.2	+	24	3330	c.3042G>A	c.(3040-3042)CGG>CGA	p.R1014R	MICAL2_uc010rch.1_Silent_p.R824R|MICAL2_uc001mka.2_Silent_p.R1014R|MICAL2_uc010rci.1_Silent_p.R993R|MICAL2_uc001mkb.2_Silent_p.R788R|MICAL2_uc001mkc.2_Silent_p.R767R|MICAL2_uc001mkd.2_Silent_p.R596R|MICAL2_uc010rcj.1_Silent_p.R226R|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	1014	LIM zinc-binding.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TGATGGAACGGCTGAGCGCCG	0.572													A	12278418	A	A	12278418	2	1	213	1	0	0	0	0	0	0	0	1	9570	1190	42	3		3	MICAL2	11	12278418	Silent	SNP	G	TCGA-28-5213-01A-01D-1486-08		12278418	122728098	35	14994											
AHNAK	79026	broad.mit.edu	37	chr11	62288237	62288237	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcctttgacatccactttgGgacctttcagatctccctcc	7	15	2	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr11:62288237G>A	uc001ntl.2	-	5	13952	c.13652C>T	c.(13651-13653)CCC>CTC	p.P4551L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4551					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATCCACTTTGGGACCTTTCAG	0.423													A	62288237	A	A	62288237	3	1	213	1	0	0	0	0	1	0	0	0	414	1232	43	3	4140	3	AHNAK	11	62288237	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	50009819	62288237	72718279	36	14995											
GANAB	23193	broad.mit.edu	37	chr11	62396739	62396739	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcttcaaatggtcccactcGgcagtgttgtcccctgtcca	8	14	2	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr11:62396739G>A	uc001nub.2	-	16	1896	c.1863C>T	c.(1861-1863)GCC>GCT	p.A621A	GANAB_uc001ntz.2_5'Flank|GANAB_uc001nua.2_Silent_p.A643A|GANAB_uc001nuc.2_Silent_p.A524A|GANAB_uc010rma.1_Silent_p.A529A|GANAB_uc010rmb.1_Silent_p.A507A	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	621					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						GGTCCCACTCGGCAGTGTTGT	0.527													A	62396739	A	A	62396739	2	1	213	1	0	0	0	0	0	0	0	1	6233	1103	39	2		2	GANAB	11	62396739	Silent	SNP	G	TCGA-28-5213-01A-01D-1486-08	108502	62396739	72609777	37	14996											
MUS81	80198	broad.mit.edu	37	chr11	65628471	65628471	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttccctccgacggtacccaCtgccgctgcgcagcgggaag	13	16	0	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr11:65628471C>T	uc001ofv.3	+	2	516	c.163C>T	c.(163-165)CTG>TTG	p.L55L	CFL1_uc001ofs.2_5'Flank|CFL1_uc001oft.2_5'Flank|CFL1_uc001ofu.2_5'Flank|MUS81_uc001ofw.3_RNA|MUS81_uc001ofx.3_5'Flank	NM_025128	NP_079404	Q96NY9	MUS81_HUMAN	MUS81 endonuclease homolog	55					DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding				0				READ - Rectum adenocarcinoma(159;0.166)		ACGGTACCCACTGCCGCTGCG	0.682								Homologous_recombination					T	65628471	T	T	65628471	2	4	213	1	0	0	0	0	0	0	0	1	9988	564	20	3		3	MUS81	11	65628471	Silent	SNP	C	TCGA-28-5213-01A-01D-1486-08	3231732	65628471	69378045	38	14997											
OR2AT4	341152	broad.mit.edu	37	chr11	74800717	74800717	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcccaatagatagaagacGggtgagccatccactgattc	10	10	0	5			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr11:74800717G>A	uc010rro.1	-	1	42	c.42C>T	c.(40-42)CCC>CCT	p.P14P		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GATAGAAGACGGGTGAGCCAT	0.478													A	74800717	A	A	74800717	2	1	213	1	0	0	0	0	0	0	0	1	10987	1103	39	2		2	OR2AT4	11	74800717	Silent	SNP	G	TCGA-28-5213-01A-01D-1486-08	9172246	74800717	60205799	39	14998											
MLL	4297	broad.mit.edu	37	chr11	118375649	118375649	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctagccctccttgtggttcAgtagagcaaggtcatggcaa	11	10	3	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr11:118375649A>C	uc001pta.2	+	27	9056	c.9033A>C	c.(9031-9033)TCA>TCC	p.S3011S	MLL_uc001ptb.2_Silent_p.S3014S	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3011					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CTTGTGGTTCAGTAGAGCAAG	0.502			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								C	118375649	C	C	118375649	2	2	213	1	0	0	0	0	0	0	0	1	9620	175	7	5		5	MLL	11	118375649	Silent	SNP	A	TCGA-28-5213-01A-01D-1486-08	43574932	118375649	16630867	40	14999											
C12orf35	55196	broad.mit.edu	37	chr12	32137685	32137685	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacccaaaacaaaacataaaAgcttaccaaggacagaacaa	4	11	0	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr12:32137685A>C	uc001rks.2	+	4	4210	c.3796A>C	c.(3796-3798)AGC>CGC	p.S1266R	C12orf35_uc001rkt.2_5'Flank	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1266										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			AAAACATAAAAGCTTACCAAG	0.348													C	32137685	C	C	32137685	3	2	213	1	0	0	0	0	1	0	0	0	1682	72	3	5	3798	5	C12orf35	12	32137685	Missense_Mutation	SNP	A	TCGA-28-5213-01A-01D-1486-08		32137685	101714210	41	15000											
LRP1	4035	broad.mit.edu	37	chr12	57562923	57562923	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttcttcccccaccgccagAcaatgactgtggggacaaca	8	16	1	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr12:57562923A>G	uc001snd.2	+	20	3462	c.2996A>G	c.(2995-2997)GAC>GGC	p.D999G	LRP1_uc009zpi.1_RNA	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	999	Extracellular (Potential).|LDL-receptor class A 6.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCACCGCCAGACAATGACTGT	0.627													G	57562923	G	G	57562923	3	3	213	1	0	0	0	0	1	0	0	0	8951	289	10	4	3074	4	LRP1	12	57562923	Missense_Mutation	SNP	A	TCGA-28-5213-01A-01D-1486-08	25425238	57562923	76288972	42	15001											
UBE3B	89910	broad.mit.edu	37	chr12	109921388	109921388	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctcagacctcgagagcatGgttcatcgatagagcccgtc	11	12	2	3			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr12:109921388G>A	uc001top.2	+	3	635	c.32G>A	c.(31-33)TGG>TAG	p.W11*	UBE3B_uc001toq.2_Nonsense_Mutation_p.W11*|UBE3B_uc001tol.1_Nonsense_Mutation_p.W11*|UBE3B_uc001tom.2_Nonsense_Mutation_p.W11*|UBE3B_uc001ton.2_Nonsense_Mutation_p.W11*|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Nonsense_Mutation_p.W11*|UBE3B_uc001tor.2_Nonsense_Mutation_p.W11*	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	11					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TCGAGAGCATGGTTCATCGAT	0.512													A	109921388	A	A	109921388	4	1	213	1	0	0	0	0	0	1	0	0	16877	1357	47	3	34	3	UBE3B	12	109921388	Nonsense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	52358465	109921388	23930507	43	15002											
KDM2B	84678	broad.mit.edu	37	chr12	121880495	121880495	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccttcggtgctgggtcccgCggtgggggagctggagcggg	21	11	0	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr12:121880495C>T	uc001uat.2	-	19	2853	c.2749G>A	c.(2749-2751)GCG>ACG	p.A917T	KDM2B_uc001uaq.2_Missense_Mutation_p.A357T|KDM2B_uc010szy.1_Missense_Mutation_p.A357T|KDM2B_uc001uar.2_Missense_Mutation_p.A508T|KDM2B_uc001uas.2_Missense_Mutation_p.A848T|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.A165T|KDM2B_uc010szx.1_Missense_Mutation_p.A165T|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	917					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CTGGGTCCCGCGGTGGGGGAG	0.627													T	121880495	T	T	121880495	3	4	213	1	0	0	0	0	1	0	0	0	8125	768	27	1	1333	1	KDM2B	12	121880495	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	11959107	121880495	11971400	44	15003											
SACS	26278	broad.mit.edu	37	chr13	23942617	23942617	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caagtggtggcgttgtctgaCcaaatcgacctaaaatacgg	11	9	1	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr13:23942617C>A	uc001uon.2	-	5	858	c.269G>T	c.(268-270)GGT>GTT	p.G90V	SACS_uc001uoo.2_5'UTR|SACS_uc001uoq.1_5'UTR	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	90					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CGTTGTCTGACCAAATCGACC	0.393													A	23942617	A	A	23942617	3	1	213	1	0	0	0	0	1	0	0	0	13804	507	18	5	13494	5	SACS	13	23942617	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08		23942617	91227261	45	15004											
ATL1	51062	broad.mit.edu	37	chr14	51027003	51027003	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catggccaagaaccgcagggAcagaaacagttggggtgagt	15	8	0	3			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr14:51027003A>G	uc001wyf.3	+	1	261	c.20A>G	c.(19-21)GAC>GGC	p.D7G	ATL1_uc001wyd.3_Missense_Mutation_p.D7G|ATL1_uc001wye.3_Missense_Mutation_p.D7G	NM_015915	NP_056999	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1 isoform a	7	Cytoplasmic.				axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			skin(3)|central_nervous_system(1)	4						AACCGCAGGGACAGAAACAGT	0.632													G	51027003	G	G	51027003	3	3	213	1	0	0	0	0	1	0	0	0	1106	275	10	4	22	4	ATL1	14	51027003	Missense_Mutation	SNP	A	TCGA-28-5213-01A-01D-1486-08		51027003	56322537	46	15005											
CLMN	79789	broad.mit.edu	37	chr14	95677204	95677204	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcccgcaaagtcctgcacCgccacgccatacctgaagga	9	17	0	1	rs139868659		TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr14:95677204C>T	uc001yef.2	-	7	737	c.621G>A	c.(619-621)GCG>GCA	p.A207A		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	207	Actin-binding.|CH 2.					integral to membrane	actin binding				0				Epithelial(152;0.193)		AGTCCTGCACCGCCACGCCAT	0.582													T	95677204	T	T	95677204	2	4	213	1	0	0	0	0	0	0	0	1	3542	639	23	2		2	CLMN	14	95677204	Silent	SNP	C	TCGA-28-5213-01A-01D-1486-08	44650201	95677204	11672336	47	15006											
ATP10A	57194	broad.mit.edu	37	chr15	25953147	25953147	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagtgcaggttggtctccaGgcgaatggcagactggaaga	15	8	1	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr15:25953147G>A	uc010ayu.2	-	12	2657	c.2551C>T	c.(2551-2553)CTG>TTG	p.L851L		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	851	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TTGGTCTCCAGGCGAATGGCA	0.537													A	25953147	A	A	25953147	2	1	213	1	0	0	0	0	0	0	0	1	1116	991	35	3		3	ATP10A	15	25953147	Silent	SNP	G	TCGA-28-5213-01A-01D-1486-08		25953147	76578245	48	15007											
SERINC4	619189	broad.mit.edu	37	chr15	44090144	44090144	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgttccaggaatgggcaaaAgctgtaataagcaccaactg	10	8	0	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr15:44090144A>G	uc010bds.1	-	3	554	c.86T>C	c.(85-87)CTT>CCT	p.L29P	ELL3_uc001zsx.1_5'UTR|C15orf63_uc001ztb.2_Intron|SERINC4_uc001ztc.1_RNA|SERINC4_uc001ztd.1_5'UTR|SERINC4_uc001zte.1_Missense_Mutation_p.L29P|C15orf63_uc001ztf.2_5'Flank|C15orf63_uc001ztg.1_5'Flank	NM_001033517	NP_001028689	A6NH21	SERC4_HUMAN	serine incorporator 4	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					phospholipid biosynthetic process	integral to membrane					0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		GBM - Glioblastoma multiforme(94;7.81e-07)		AATGGGCAAAAGCTGTAATAA	0.463											OREG0003944	type=REGULATORY REGION|Gene=AK094716|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	G	44090144	G	G	44090144	3	3	213	1	0	0	0	0	1	0	0	0	14082	72	3	4	766	4	SERINC4	15	44090144	Missense_Mutation	SNP	A	TCGA-28-5213-01A-01D-1486-08	18136997	44090144	58441248	49	15008											
GRIN2A	2903	broad.mit.edu	37	chr16	9857047	9857047	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcattttcttgtacacgcGtctattgctgcaggaattta	9	8	2	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr16:9857047G>A	uc002czo.3	-	13	4902	c.4354C>T	c.(4354-4356)CGC>TGC	p.R1452C	GRIN2A_uc010uym.1_Missense_Mutation_p.R1452C|GRIN2A_uc010uyn.1_3'UTR|GRIN2A_uc002czr.3_3'UTR	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1452	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGTACACGCGTCTATTGCTG	0.363													A	9857047	A	A	9857047	3	1	213	1	0	0	0	0	1	0	0	0	6779	1145	40	1	44	1	GRIN2A	16	9857047	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08		9857047	80497706	50	15009											
GRIN2A	2903	broad.mit.edu	37	chr16	9934645	9934645	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaactgccatgactgcccGttgatagaccacctggatgc	10	14	0	3			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr16:9934645G>A	uc002czo.3	-	7	2058	c.1510C>T	c.(1510-1512)CGG>TGG	p.R504W	GRIN2A_uc010uym.1_Missense_Mutation_p.R504W|GRIN2A_uc010uyn.1_Missense_Mutation_p.R347W|GRIN2A_uc002czr.3_Missense_Mutation_p.R504W	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	504	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGACTGCCCGTTGATAGACC	0.453													A	9934645	A	A	9934645	3	1	213	1	0	0	0	0	1	0	0	0	6779	1144	40	1	2912	1	GRIN2A	16	9934645	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	77598	9934645	80420108	51	15010											
CDH15	1013	broad.mit.edu	37	chr16	89261354	89261354	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgagggtgacggctcggtgGcggggacgctgagctccatc	18	11	0	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr16:89261354G>A	uc002fmt.2	+	14	2313	c.2236G>A	c.(2236-2238)GCG>ACG	p.A746T		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	746	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CGGCTCGGTGGCGGGGACGCT	0.637													A	89261354	A	A	89261354	3	1	213	1	0	0	0	0	1	0	0	0	3100	1203	42	3	2290	3	CDH15	16	89261354	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	79326709	89261354	1093399	52	15011											
PFAS	5198	broad.mit.edu	37	chr17	8158344	8158344	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accatcaggcccattgttcaGgctgaacttctccaccccaa	6	16	3	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr17:8158344G>A	uc002gkr.2	+	4	420	c.279_splice	c.e4-1	p.R93_splice	PFAS_uc010vuv.1_Splice_Site	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase						'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCATTGTTCAGGCTGAACTTC	0.632													A	8158344	A	A	8158344	5	1	213	1	0	0	0	0	0	0	1	0	11754	1014	35	3	288	3	PFAS	17	8158344	Splice_Site	SNP	G	TCGA-28-5213-01A-01D-1486-08		8158344	73036866	53	15012											
NTN1	9423	broad.mit.edu	37	chr17	9066204	9066204	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctttcggggcgcaagagcGgaggtgtctgcctcaactgt	15	10	2	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr17:9066204G>A	uc002glw.3	+	3	1200	c.1093G>A	c.(1093-1095)GGA>AGA	p.G365R		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	365	Laminin EGF-like 2.				apoptosis|axon guidance		protein binding				0						GCGCAAGAGCGGAGGTGTCTG	0.627													A	9066204	A	A	9066204	3	1	213	1	0	0	0	0	1	0	0	0	10700	1117	39	2	1099	2	NTN1	17	9066204	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	907860	9066204	72129006	54	15013											
DGKE	8526	broad.mit.edu	37	chr17	54925329	54925329	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tatcaaagccctacaactctGtactcttctcccatattatt	2	13	4	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr17:54925329G>T	uc002iur.2	+	5	971	c.791G>T	c.(790-792)TGT>TTT	p.C264F	DGKE_uc002ius.1_Missense_Mutation_p.C264F	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	264	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)					CTACAACTCTGTACTCTTCTC	0.388													T	54925329	T	T	54925329	3	4	213	1	0	0	0	0	1	0	0	0	4468	1377	48	5	805	5	DGKE	17	54925329	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	45859125	54925329	26269881	55	15014											
MIDN	90007	broad.mit.edu	37	chr19	1257138	1257138	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcacccagccgcaaggccgGccgcagcgacagcagtagca	13	16	1	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr19:1257138G>A	uc002lrp.2	+	8	1789	c.1274G>A	c.(1273-1275)GGC>GAC	p.G425D		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	425						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCAAGGCCGGCCGCAGCGAC	0.697													A	1257138	A	A	1257138	3	1	213	1	0	0	0	0	1	0	0	0	9579	1203	42	3	1300	3	MIDN	19	1257138	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08		1257138	57871845	56	15015											
FUT3	2525	broad.mit.edu	37	chr19	5844200	5844200	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cgtccgtacacgtccaccttGagatgagcctgcaggctctg	11	14	1	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr19:5844200G>A	uc002mdk.2	-	2	748	c.651C>T	c.(649-651)CTC>CTT	p.L217L	FUT3_uc002mdm.2_Silent_p.L217L|FUT3_uc002mdj.2_Silent_p.L217L|FUT3_uc002mdl.2_Silent_p.L217L	NM_001097641	NP_001091110	P21217	FUT3_HUMAN	fucosyltransferase 3	217	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity				0						CGTCCACCTTGAGATGAGCCT	0.622													A	5844200	A	A	5844200	2	1	213	1	0	0	0	0	0	0	0	1	6105	1277	45	3		3	FUT3	19	5844200	Silent	SNP	G	TCGA-28-5213-01A-01D-1486-08	4587062	5844200	53284783	57	15016											
RAB11B	9230	broad.mit.edu	37	chr19	8464851	8464851	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaccatcggcgtggagttcGccacccgcagcatccaggtg	13	15	0	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr19:8464851G>T	uc002mju.3	+	2	241	c.145G>T	c.(145-147)GCC>TCC	p.A49S	RAB11B_uc010xkd.1_Missense_Mutation_p.A49S	NM_004218	NP_004209	Q15907	RB11B_HUMAN	RAB11B, member RAS oncogene family	49					cell cycle|protein transport|small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity				0						CGTGGAGTTCGCCACCCGCAG	0.652													T	8464851	T	T	8464851	3	4	213	1	0	0	0	0	1	0	0	0	12892	1087	38	5	151	5	RAB11B	19	8464851	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08	2620651	8464851	50664132	58	15017											
MUC16	94025	broad.mit.edu	37	chr19	9069909	9069909	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caaaaggaaaagtggagagcCtggtgatggtttctgtggag	16	4	1	2			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr19:9069909C>A	uc002mkp.2	-	3	17741	c.17537G>T	c.(17536-17538)AGG>ATG	p.R5846M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5848	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTGGAGAGCCTGGTGATGGT	0.488													A	9069909	A	A	9069909	3	1	213	1	0	0	0	0	1	0	0	0	9973	681	24	5	26314	5	MUC16	19	9069909	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	605058	9069909	50059074	59	15018											
FBXL12	54850	broad.mit.edu	37	chr19	9929295	9929296	+	Splice_Site	INS	-	G	G													ttccagcggtgacagaccctINSgggggaggggacgcgcggtt							TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr19:9929295_9929296insG	uc002mme.2	-	2	329	c.87_splice	c.e2-1	p.R29_splice	FBXL12_uc002mmd.2_5'UTR|FBXL12_uc002mmf.2_Splice_Site|FBXL12_uc002mmg.2_Splice_Site|FBXL12_uc002mmh.2_Splice_Site	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12								protein binding			lung(1)|kidney(1)	2						TGACAGACCCTGGGGGAGGGGA	0.723													G	9929296	G	G	9929295	8	5	213	1	0	1	1	0	0	0	1	0	5708	1594	55	0	903	0	FBXL12	19	9929295	Splice_Site	INS	-	TCGA-28-5213-01A-01D-1486-08	859386	9929295	49199688	60	15019											
MATN4	8785	broad.mit.edu	37	chr20	43933304	43933304	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcacgccaacgcgcgtggcGttgggacccacgttcaggcc	13	15	2	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr20:43933304G>A	uc002xnn.2	-	3	394	c.207C>T	c.(205-207)AAC>AAT	p.N69N	MATN4_uc002xno.2_Silent_p.N69N|MATN4_uc002xnp.2_Silent_p.N69N|MATN4_uc010zwr.1_Silent_p.N17N|MATN4_uc002xnr.1_Silent_p.N69N|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	69	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				CGCGCGTGGCGTTGGGACCCA	0.642													A	43933304	A	A	43933304	2	1	213	1	0	0	0	0	0	0	0	1	9336	1136	40	1		1	MATN4	20	43933304	Silent	SNP	G	TCGA-28-5213-01A-01D-1486-08		43933304	19092216	61	15020											
LAMA5	3911	broad.mit.edu	37	chr20	60897158	60897158	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtgtcgcagcgctccccgCtgagccccggggggcagttg	17	14	0	1	rs143066016	byFrequency	TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chr20:60897158C>T	uc002ycq.2	-	48	6480	c.6413G>A	c.(6412-6414)AGC>AAC	p.S2138N		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2138	Laminin EGF-like 22.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCGCTCCCCGCTGAGCCCCGG	0.701													T	60897158	T	T	60897158	3	4	213	1	0	0	0	0	1	0	0	0	8609	797	28	3	4806	3	LAMA5	20	60897158	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	16963854	60897158	2128362	62	15021											
ASMT	438	broad.mit.edu	37	chrX	1746630	1746630	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtacctggagacgtttggcGttcccgctgaagagcttttt	12	9	0	3			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chrX:1746630G>A	uc004cqd.2	+	5	554	c.409G>A	c.(409-411)GTT>ATT	p.V137I	ASMT_uc010ncy.2_Missense_Mutation_p.V137I|ASMT_uc004cqe.2_Missense_Mutation_p.V137I	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	137					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GACGTTTGGCGTTCCCGCTGA	0.338													A	1746630	A	A	1746630	3	1	213	1	0	0	0	0	1	0	0	0	1045	1145	40	1	423	1	ASMT	23	1746630	Missense_Mutation	SNP	G	TCGA-28-5213-01A-01D-1486-08		1746630	153523930	63	15022											
NR0B1	190	broad.mit.edu	37	chrX	30327199	30327199	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agcgtcgcctcgggcgccttCggtgccgcgtacgtttgctt	14	14	0	0			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chrX:30327199C>T	uc004dcf.3	-	1	297	c.282G>A	c.(280-282)CCG>CCA	p.P94P		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	94	4 X 67 AA tandem repeats.|2.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	CGGGCGCCTTCGGTGCCGCGT	0.687													T	30327199	T	T	30327199	2	4	213	1	0	0	0	0	0	0	0	1	10613	871	31	2		2	NR0B1	23	30327199	Silent	SNP	C	TCGA-28-5213-01A-01D-1486-08	28580569	30327199	124943361	64	15023											
KIAA2022	340533	broad.mit.edu	37	chrX	73962950	73962950	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atctgacttttctcttggctCgcagcccatagttctgttgg	9	11	3	1			TCGA-28-5213-01A-01D-1486-08	TCGA-28-5213-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	b866e742-5ed0-4d7d-b96c-52f8f6f37142	c73947a3-b996-4e71-98ea-c30c8de3069c	g.chrX:73962950C>T	uc004eby.2	-	3	2059	c.1442G>A	c.(1441-1443)CGA>CAA	p.R481Q		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	481					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TCTCTTGGCTCGCAGCCCATA	0.453													T	73962950	T	T	73962950	3	4	213	1	0	0	0	0	1	0	0	0	8269	884	31	2	3116	2	KIAA2022	23	73962950	Missense_Mutation	SNP	C	TCGA-28-5213-01A-01D-1486-08	43635751	73962950	81307610	65	15024											
CPSF3L	54973	broad.mit.edu	37	chr1	1256376	1256376	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctgcccaagggactcacGtcgtcattgaagcccatgtg	10	14	2	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:1256376G>A	uc001aee.1	-	2	184	c.126C>T	c.(124-126)GAC>GAT	p.D42D	CPSF3L_uc001aef.1_Silent_p.D48D|CPSF3L_uc009vjz.1_Silent_p.D42D|CPSF3L_uc010nyj.1_Silent_p.D13D|CPSF3L_uc001aeg.1_Translation_Start_Site|CPSF3L_uc001aeh.1_Silent_p.D42D|CPSF3L_uc001aei.1_Intron|CPSF3L_uc001aej.1_Missense_Mutation_p.T15I|CPSF3L_uc001aek.1_Intron|CPSF3L_uc001aem.1_Silent_p.D42D|CPSF3L_uc001ael.1_Translation_Start_Site|CPSF3L_uc001aen.1_Silent_p.D42D	NM_017871	NP_060341	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor	42						Golgi apparatus|nucleus	hydrolase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		AGGGACTCACGTCGTCATTGA	0.647													A	1256376	A	A	1256376	2	1	214	1	0	0	0	0	0	0	0	1	3827	1159	40	1		1	CPSF3L	1	1256376	Silent	SNP	G	TCGA-28-5214-01A-01D-1486-08		1256376	247994245	1	15025											
NPHP4	261734	broad.mit.edu	37	chr1	5937354	5937354	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtgcttgcaccacgtgTtttcctgcgaaagggtcaga	11	10	2	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:5937354T>C	uc001alq.1	-	20	2882	c.2616A>G	c.(2614-2616)AAA>AAG	p.K872K	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_RNA	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	872					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GCACCACGTGTTTTCCTGCGA	0.632													C	5937354	C	C	5937354	2	2	214	1	0	0	0	0	0	0	0	1	10581	1722	60	4		4	NPHP4	1	5937354	Silent	SNP	T	TCGA-28-5214-01A-01D-1486-08	4680978	5937354	243313267	2	15026											
MACF1	23499	broad.mit.edu	37	chr1	39833905	39833905	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgagctcttgtggctttgCgctggacttgtgccagcatc	12	11	1	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:39833905C>T	uc010oiu.1	+	14	8308	c.8177C>T	c.(8176-8178)GCG>GTG	p.A2726V	MACF1_uc010ois.1_Missense_Mutation_p.A2224V|MACF1_uc001cda.1_Missense_Mutation_p.A2132V|MACF1_uc001cdc.1_Missense_Mutation_p.A1311V|MACF1_uc001cdb.1_Missense_Mutation_p.A1311V	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4291					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTGGCTTTGCGCTGGACTTG	0.453													T	39833905	T	T	39833905	3	4	214	1	0	0	0	0	1	0	0	0	9144	768	27	1	13000	1	MACF1	1	39833905	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	33896551	39833905	209416716	3	15027											
CLCA2	9635	broad.mit.edu	37	chr1	86916416	86916416	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccaggttacacagcaaacGgtaagaaccattagcactgt	8	10	0	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:86916416G>A	uc001dlr.3	+	12	2317	c.2155G>A	c.(2155-2157)GGT>AGT	p.G719S		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	719	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		CACAGCAAACGGTAAGAACCA	0.453													A	86916416	A	A	86916416	3	1	214	1	0	0	0	0	1	0	0	0	3458	1130	39	2	2201	2	CLCA2	1	86916416	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	47082511	86916416	162334205	4	15028											
EPHX4	253152	broad.mit.edu	37	chr1	92528664	92528664	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccaacactactactgtggGgagagaatgacgcattcatg	10	10	1	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:92528664G>A	uc001don.2	+	7	1014	c.910G>A	c.(910-912)GGA>AGA	p.G304R		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	304						integral to membrane	hydrolase activity			central_nervous_system(1)	1						ACTACTGTGGGGAGAGAATGA	0.398													A	92528664	A	A	92528664	3	1	214	1	0	0	0	0	1	0	0	0	5182	1233	43	3	936	3	EPHX4	1	92528664	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	5612248	92528664	156721957	5	15029											
DPYD	1806	broad.mit.edu	37	chr1	98293688	98293688	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acctcattgcttctcggagaGctcctcgctcaccaagagtc	8	15	3	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:98293688G>C	uc001drv.2	-	3	352	c.215C>G	c.(214-216)GCT>GGT	p.A72G	DPYD_uc010oub.1_RNA|DPYD_uc001drw.2_Missense_Mutation_p.A72G	NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	72	4Fe-4S ferredoxin-type 1.				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TTCTCGGAGAGCTCCTCGCTC	0.393													C	98293688	C	C	98293688	3	2	214	1	0	0	0	0	1	0	0	0	4745	971	34	5	2989	5	DPYD	1	98293688	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	5765024	98293688	150956933	6	15030											
FLG	2312	broad.mit.edu	37	chr1	152280977	152280977	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgaccctcttgggatgctgAgtgcctggagctgtcttgtg	14	10	2	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:152280977A>G	uc001ezu.1	-	3	6421	c.6385T>C	c.(6385-6387)TCA>CCA	p.S2129P		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2129	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGGATGCTGAGTGCCTGGAG	0.572									Ichthyosis				G	152280977	G	G	152280977	3	3	214	1	0	0	0	0	1	0	0	0	5922	304	11	4	5804	4	FLG	1	152280977	Missense_Mutation	SNP	A	TCGA-28-5214-01A-01D-1486-08	53987289	152280977	96969644	7	15031											
FLG	2312	broad.mit.edu	37	chr1	152282616	152282616	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcctgcttgtcttggacccCgctgattctccctggcccac	9	18	2	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:152282616C>T	uc001ezu.1	-	3	4782	c.4746G>A	c.(4744-4746)GCG>GCA	p.A1582A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1582	Ser-rich.|Filaggrin 9.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTTGGACCCCGCTGATTCTC	0.602									Ichthyosis				T	152282616	T	T	152282616	2	4	214	1	0	0	0	0	0	0	0	1	5922	639	23	2		2	FLG	1	152282616	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08	1639	152282616	96968005	8	15032											
PKP1	5317	broad.mit.edu	37	chr1	201289494	201289494	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaactgtgtagcggccagCcgctgtgacgacaaggtgag	15	10	0	3			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:201289494C>T	uc001gwd.2	+	8	1646	c.1395C>T	c.(1393-1395)AGC>AGT	p.S465S	PKP1_uc001gwe.2_Silent_p.S444S|PKP1_uc009wzm.2_Silent_p.S52S	NM_000299	NP_000290	Q13835	PKP1_HUMAN	plakophilin 1 isoform 1b	465					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			ovary(2)	2						TAGCGGCCAGCCGCTGTGACG	0.612													T	201289494	T	T	201289494	2	4	214	1	0	0	0	0	0	0	0	1	11984	738	26	3		3	PKP1	1	201289494	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08	49006878	201289494	47961127	9	15033											
USH2A	7399	broad.mit.edu	37	chr1	216061963	216061963	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aacctcatggaatgactcctCgggagagtcaccagggtagt	12	10	2	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr1:216061963C>T	uc001hku.1	-	41	8415	c.8028G>A	c.(8026-8028)CCG>CCA	p.P2676P		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2676	Extracellular (Potential).|Fibronectin type-III 13.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AATGACTCCTCGGGAGAGTCA	0.468										HNSCC(13;0.011)			T	216061963	T	T	216061963	2	4	214	1	0	0	0	0	0	0	0	1	17033	871	31	2		2	USH2A	1	216061963	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08	14772469	216061963	33188658	10	15034											
POLR1A	25885	broad.mit.edu	37	chr2	86272753	86272753	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacatacaggaggtttgatgCcggtgaggaacctgccagtg	14	8	0	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr2:86272753C>T	uc002sqs.2	-	20	3252	c.2873G>A	c.(2872-2874)GGC>GAC	p.G958D	POLR1A_uc010ytb.1_Missense_Mutation_p.G324D|POLR1A_uc002sqt.1_5'Flank	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	958					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AGGTTTGATGCCGGTGAGGAA	0.512													T	86272753	T	T	86272753	3	4	214	1	0	0	0	0	1	0	0	0	12209	739	26	3	2349	3	POLR1A	2	86272753	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08		86272753	156926620	11	15035											
PCDP1	200373	broad.mit.edu	37	chr2	120385285	120385285	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcaggatgattataccagcCggttctctgtgtcgcccaag	11	11	2	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr2:120385285C>T	uc002tmb.2	+	17	1807	c.715C>T	c.(715-717)CGG>TGG	p.R239W	PCDP1_uc010yyq.1_Missense_Mutation_p.R369W	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	525						cilium	calmodulin binding				0	Colorectal(110;0.196)					TTATACCAGCCGGTTCTCTGT	0.537													T	120385285	T	T	120385285	3	4	214	1	0	0	0	0	1	0	0	0	11572	643	23	2	745	2	PCDP1	2	120385285	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	34112532	120385285	122814088	12	15036											
ZNF142	7701	broad.mit.edu	37	chr2	219503257	219503257	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccttgtagttgcagaggcgGcaaaagaaggggtggcggtc	18	7	0	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr2:219503257G>A	uc002vin.2	-	10	5305	c.4869C>T	c.(4867-4869)TGC>TGT	p.C1623C	ZNF142_uc002vil.2_Silent_p.C1584C|ZNF142_uc010fvt.2_Silent_p.C1460C|ZNF142_uc002vim.2_Silent_p.C1460C	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1623	C2H2-type 31.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TGCAGAGGCGGCAAAAGAAGG	0.607													A	219503257	A	A	219503257	2	1	214	1	0	0	0	0	0	0	0	1	17728	1195	42	3		3	ZNF142	2	219503257	Silent	SNP	G	TCGA-28-5214-01A-01D-1486-08	99117972	219503257	23696116	13	15037											
SCN11A	11280	broad.mit.edu	37	chr3	38892224	38892224	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttgtgactatgtcgaacaCgagaccttgacatttgttct	9	9	1	3			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr3:38892224C>T	uc011ays.1	-	25	4274	c.4075G>A	c.(4075-4077)GTG>ATG	p.V1359M	SCN11A_uc003cis.1_Missense_Mutation_p.V24M	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1359					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ATGTCGAACACGAGACCTTGA	0.308													T	38892224	T	T	38892224	3	4	214	1	0	0	0	0	1	0	0	0	13913	536	19	1	1308	1	SCN11A	3	38892224	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08		38892224	159130206	14	15038											
GPR128	84873	broad.mit.edu	37	chr3	100349573	100349573	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttttgtgaaaatagtacctAtatgggttttacttttgcca	7	5	0	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr3:100349573A>G	uc003duc.2	+	3	522	c.254A>G	c.(253-255)TAT>TGT	p.Y85C		NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	85	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						AATAGTACCTATATGGGTTTT	0.318													G	100349573	G	G	100349573	3	3	214	1	0	0	0	0	1	0	0	0	6641	449	16	4	264	4	GPR128	3	100349573	Missense_Mutation	SNP	A	TCGA-28-5214-01A-01D-1486-08	61457349	100349573	97672857	15	15039											
EPHB1	2047	broad.mit.edu	37	chr3	134898744	134898744	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cattgaccccttcacttacgAggatcccaacgaagctgtcc	7	15	1	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr3:134898744A>G	uc003eqt.2	+	10	2022	c.1802A>G	c.(1801-1803)GAG>GGG	p.E601G	EPHB1_uc003equ.2_Missense_Mutation_p.E162G	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	601	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TTCACTTACGAGGATCCCAAC	0.483													G	134898744	G	G	134898744	3	3	214	1	0	0	0	0	1	0	0	0	5174	304	11	4	1840	4	EPHB1	3	134898744	Missense_Mutation	SNP	A	TCGA-28-5214-01A-01D-1486-08	34549171	134898744	63123686	16	15040											
CORIN	10699	broad.mit.edu	37	chr4	47679958	47679958	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtgggacacacttactgaCgctgcagttctcctcatcac	9	13	3	1	rs149563697	byFrequency	TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr4:47679958C>T	uc003gxm.2	-	9	1339	c.1246G>A	c.(1246-1248)GTC>ATC	p.V416I	CORIN_uc011bzf.1_Missense_Mutation_p.V277I|CORIN_uc011bzg.1_Missense_Mutation_p.V349I|CORIN_uc011bzh.1_Missense_Mutation_p.V379I|CORIN_uc011bzi.1_Missense_Mutation_p.V379I	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	416	Extracellular (Potential).				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						CACTTACTGACGCTGCAGTTC	0.493													T	47679958	T	T	47679958	3	4	214	1	0	0	0	0	1	0	0	0	3752	536	19	1	1938	1	CORIN	4	47679958	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08		47679958	143474318	17	15041											
UGT2B15	7366	broad.mit.edu	37	chr4	69536075	69536075	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gagaattttcagaagagaatCttccaaataatttttagtta	6	4	2	3			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr4:69536075C>A	uc011cal.1	-	1	300	c.262G>T	c.(262-264)GAT>TAT	p.D88Y		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	88					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						AGAAGAGAATCTTCCAAATAA	0.294													A	69536075	A	A	69536075	3	1	214	1	0	0	0	0	1	0	0	0	16955	913	32	5	2971	5	UGT2B15	4	69536075	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	21856117	69536075	121618201	18	15042											
WDFY3	23001	broad.mit.edu	37	chr4	85611704	85611704	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttttctttggaggtgcccatCtcccacacacacacaaccgt	6	15	2	0			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr4:85611704C>G	uc003hpd.2	-	61	9726	c.9318G>C	c.(9316-9318)GAG>GAC	p.E3106D		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	3106	WD 1.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGGTGCCCATCTCCCACACAC	0.517													G	85611704	G	G	85611704	3	3	214	1	0	0	0	0	1	0	0	0	17267	912	32	5	1294	5	WDFY3	4	85611704	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	16075629	85611704	105542572	19	15043											
FSTL5	56884	broad.mit.edu	37	chr4	162577555	162577555	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgggaggtctcagggttccTtgaatggcacagctcagaac	13	9	2	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr4:162577555T>C	uc003iqh.2	-	7	1255	c.819A>G	c.(817-819)CAA>CAG	p.Q273Q	FSTL5_uc003iqi.2_Silent_p.Q272Q|FSTL5_uc010iqv.2_Silent_p.Q272Q	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	273	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TCAGGGTTCCTTGAATGGCAC	0.388													C	162577555	C	C	162577555	2	2	214	1	0	0	0	0	0	0	0	1	6080	1606	56	4		4	FSTL5	4	162577555	Silent	SNP	T	TCGA-28-5214-01A-01D-1486-08	76965851	162577555	28576721	20	15044											
CDH9	1007	broad.mit.edu	37	chr5	26988213	26988213	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tctcatacaaaaattcttacCttgcctacatattgtgtgtc	4	10	2	0			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr5:26988213C>G	uc003jgs.1	-	2	397	c.228G>C	c.(226-228)AAG>AAC	p.K76N	CDH9_uc010iug.2_Missense_Mutation_p.K76N	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	76	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AAATTCTTACCTTGCCTACAT	0.348													G	26988213	G	G	26988213	3	3	214	1	0	0	0	0	1	0	0	0	3117	695	24	5	2185	5	CDH9	5	26988213	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08		26988213	153927047	21	15045											
C5orf48	389320	broad.mit.edu	37	chr5	125971812	125971812	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctttgccatggggaagatcGtaaagttgtcttccaaaaag	11	7	1	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr5:125971812G>A	uc003kub.1	+	3	297	c.284G>A	c.(283-285)CGT>CAT	p.R95H		NM_207408	NP_997291	Q6ZNM6	CE048_HUMAN	hypothetical protein LOC389320	95										ovary(1)	1						GGGGAAGATCGTAAAGTTGTC	0.443													A	125971812	A	A	125971812	3	1	214	1	0	0	0	0	1	0	0	0	2306	1145	40	1	294	1	C5orf48	5	125971812	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	98983599	125971812	54943448	22	15046											
IK	3550	broad.mit.edu	37	chr5	140033536	140033536	+	Frame_Shift_Del	DEL	G	-	-													tatacagggacaaatcagctGcagagaagagaagacagttg							TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr5:140033536delG	uc003lgq.2	+	6	528	c.418delG	c.(418-420)GCAfs	p.A140fs	IK_uc011czk.1_Frame_Shift_Del_p.A140fs	NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	140					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAATCAGCTGCAGAGAAGAG	0.328													-	140033536	-	-	140033536	7	5	214	1	0	1	0	1	0	0	0	0	7608	1319	46	0	440	0	IK	5	140033536	Frame_Shift_Del	DEL	G	TCGA-28-5214-01A-01D-1486-08	14061724	140033536	40881724	23	15047											
PCDHGA9	56107	broad.mit.edu	37	chr5	140783915	140783915	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctacctcccggaaaacaacGccagaggtacttccatcttc	6	15	2	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr5:140783915G>A	uc003lkh.1	+	1	1396	c.1396G>A	c.(1396-1398)GCC>ACC	p.A466T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.A466T	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	466	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAAAACAACGCCAGAGGTAC	0.468													A	140783915	A	A	140783915	3	1	214	1	0	0	0	0	1	0	0	0	11561	1087	38	1	1398	1	PCDHGA9	5	140783915	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	750379	140783915	40131345	24	15048											
GRIA1	2890	broad.mit.edu	37	chr5	153149798	153149798	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagccatcagtttttgtgcGgaccacagaggaggggatga	15	7	1	3			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr5:153149798G>A	uc003lva.3	+	13	2458	c.2093G>A	c.(2092-2094)CGG>CAG	p.R698Q	GRIA1_uc003luy.3_Missense_Mutation_p.R698Q|GRIA1_uc003luz.3_Missense_Mutation_p.R603Q|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.R618Q|GRIA1_uc011dcx.1_Missense_Mutation_p.R629Q|GRIA1_uc011dcy.1_Missense_Mutation_p.R708Q|GRIA1_uc011dcz.1_Missense_Mutation_p.R708Q	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	698	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GTTTTTGTGCGGACCACAGAG	0.468													A	153149798	A	A	153149798	3	1	214	1	0	0	0	0	1	0	0	0	6767	1116	39	2	2143	2	GRIA1	5	153149798	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	12365883	153149798	27765462	25	15049											
RNF130	55819	broad.mit.edu	37	chr5	179393829	179393829	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttactgcaatgttgatttctCctgttctcggagtgagctcc	9	10	2	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr5:179393829C>T	uc003mll.1	-	7	1534	c.1127G>A	c.(1126-1128)GGA>GAA	p.G376E	RNF130_uc003mlm.1_Missense_Mutation_p.G376E	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	376	Cytoplasmic (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTGATTTCTCCTGTTCTCGG	0.587													T	179393829	T	T	179393829	3	4	214	1	0	0	0	0	1	0	0	0	13438	855	30	3	144	3	RNF130	5	179393829	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	26244031	179393829	1521431	26	15050											
HIVEP1	3096	broad.mit.edu	37	chr6	12123451	12123451	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcatccagcacaccaactcCctgagcaggcccaactcatt	6	17	2	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr6:12123451C>T	uc003nac.2	+	4	3602	c.3423C>T	c.(3421-3423)TCC>TCT	p.S1141S	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1141					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ACACCAACTCCCTGAGCAGGC	0.507													T	12123451	T	T	12123451	2	4	214	1	0	0	0	0	0	0	0	1	7186	610	22	3		3	HIVEP1	6	12123451	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08		12123451	158991616	27	15051											
PGK2	5232	broad.mit.edu	37	chr6	49754388	49754388	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccaccatggaactatgagcGcggtgtgcagtgccaaaagc	12	12	0	1	rs147140024	byFrequency	TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr6:49754388G>A	uc003ozu.2	-	1	620	c.513C>T	c.(511-513)CGC>CGT	p.R171R		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	171		Substrate (By similarity).			glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					AACTATGAGCGCGGTGTGCAG	0.458													A	49754388	A	A	49754388	2	1	214	1	0	0	0	0	0	0	0	1	11791	1074	38	1		1	PGK2	6	49754388	Silent	SNP	G	TCGA-28-5214-01A-01D-1486-08	37630937	49754388	121360679	28	15052											
INHBA	3624	broad.mit.edu	37	chr7	41729925	41729925	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttcagagagcaacagttcacTcctctccccctttaagccca	5	16	3	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr7:41729925T>A	uc003thq.2	-	2	839	c.604A>T	c.(604-606)AGT>TGT	p.S202C	INHBA_uc003thr.2_Missense_Mutation_p.S202C	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	202					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						AACAGTTCACTCCTCTCCCCC	0.582										TSP Lung(11;0.080)			A	41729925	A	A	41729925	3	1	214	1	0	0	0	0	1	0	0	0	7741	1551	54	5	680	5	INHBA	7	41729925	Missense_Mutation	SNP	T	TCGA-28-5214-01A-01D-1486-08		41729925	117408738	29	15053											
TMEM120A	83862	broad.mit.edu	37	chr7	75617603	75617603	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgatgaggatgctctcccggAtggtcagggtgcagtagtac	15	8	2	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr7:75617603A>C	uc003ued.2	-	7	634	c.530T>G	c.(529-531)ATC>AGC	p.I177S	TMEM120A_uc003uee.2_Missense_Mutation_p.I81S|TMEM120A_uc003ueb.1_5'Flank|TMEM120A_uc003uec.2_Missense_Mutation_p.I81S	NM_031925	NP_114131	Q9BXJ8	T120A_HUMAN	transmembrane protein 120A	177	Helical; (Potential).					integral to membrane					0						GCTCTCCCGGATGGTCAGGGT	0.652													C	75617603	C	C	75617603	3	2	214	1	0	0	0	0	1	0	0	0	16030	333	12	5	529	5	TMEM120A	7	75617603	Missense_Mutation	SNP	A	TCGA-28-5214-01A-01D-1486-08	33887678	75617603	83521060	30	15054											
SMURF1	57154	broad.mit.edu	37	chr7	98636012	98636012	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccgacaggtggcattaccGgacgtattctttcttattct	8	12	3	0			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr7:98636012G>A	uc003upu.1	-	15	2085	c.1765C>T	c.(1765-1767)CGG>TGG	p.R589W	SMURF1_uc003upv.1_Missense_Mutation_p.R563W|SMURF1_uc003upt.2_Missense_Mutation_p.R563W	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	589	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			TGGCATTACCGGACGTATTCT	0.577													A	98636012	A	A	98636012	3	1	214	1	0	0	0	0	1	0	0	0	14819	1130	39	2	528	2	SMURF1	7	98636012	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	23018409	98636012	60502651	31	15055											
PIK3CG	5294	broad.mit.edu	37	chr7	106509059	106509059	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccacgagagtgtgttcacCgtgtccctgtgggactgcga	14	11	1	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr7:106509059C>T	uc003vdv.3	+	2	1138	c.1053C>T	c.(1051-1053)ACC>ACT	p.T351T	PIK3CG_uc003vdu.2_Silent_p.T351T|PIK3CG_uc003vdw.2_Silent_p.T351T	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	351					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GTGTGTTCACCGTGTCCCTGT	0.572													T	106509059	T	T	106509059	2	4	214	1	0	0	0	0	0	0	0	1	11916	639	23	2		2	PIK3CG	7	106509059	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08	7873047	106509059	52629604	32	15056											
PRSS1	5644	broad.mit.edu	37	chr7	142460295	142460295	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcacagccgactacccagaCgagctgcagtgcctggatgc	11	15	1	1	rs146076691		TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr7:142460295C>T	uc003wak.2	+	4	485	c.468C>T	c.(466-468)GAC>GAT	p.D156D	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Silent_p.D96D	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	156	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			ACTACCCAGACGAGCTGCAGT	0.507									Hereditary_Pancreatitis				T	142460295	T	T	142460295	2	4	214	1	0	0	0	0	0	0	0	1	12614	535	19	1		1	PRSS1	7	142460295	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08	35951236	142460295	16678368	33	15057											
TRAPPC9	83696	broad.mit.edu	37	chr8	141310662	141310662	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgttctgacccagcaagctTttcattttgtgtggccggag	11	10	2	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr8:141310662T>C	uc003yvj.2	-	11	1808	c.1674A>G	c.(1672-1674)AAA>AAG	p.K558K	TRAPPC9_uc003yvh.2_Silent_p.K656K|TRAPPC9_uc003yvi.1_Silent_p.K549K	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	558					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						CCAGCAAGCTTTTCATTTTGT	0.443													C	141310662	C	C	141310662	2	2	214	1	0	0	0	0	0	0	0	1	16462	1838	64	4		4	TRAPPC9	8	141310662	Silent	SNP	T	TCGA-28-5214-01A-01D-1486-08		141310662	5053360	34	15058											
LINGO2	158038	broad.mit.edu	37	chr9	27949565	27949565	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaactgcagggtgggctgtcGctgcaagatccagagaaggc	15	9	0	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr9:27949565G>A	uc003zqu.1	-	2	1299	c.1105C>T	c.(1105-1107)CGA>TGA	p.R369*	LINGO2_uc010mjf.1_Nonsense_Mutation_p.R369*|LINGO2_uc003zqv.1_Nonsense_Mutation_p.R369*	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	369	LRRCT.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		GTGGGCTGTCGCTGCAAGATC	0.547													A	27949565	A	A	27949565	4	1	214	1	0	0	0	0	0	1	0	0	8815	1095	38	1	719	1	LINGO2	9	27949565	Nonsense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08		27949565	113263866	35	15059											
KLF9	687	broad.mit.edu	37	chr9	73002796	73002796	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtcactcctcatgaagcGcttctcacacagcggacagc	10	14	3	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr9:73002796G>A	uc004aht.2	-	2	1925	c.631C>T	c.(631-633)CGC>TGC	p.R211C		NM_001206	NP_001197	Q13886	KLF9_HUMAN	Kruppel-like factor 9	211	C2H2-type 3.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CTCATGAAGCGCTTCTCACAC	0.592													A	73002796	A	A	73002796	3	1	214	1	0	0	0	0	1	0	0	0	8353	1087	38	1	107	1	KLF9	9	73002796	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	45053231	73002796	68210635	36	15060											
EPB41L4B	54566	broad.mit.edu	37	chr9	112015778	112015778	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actaggcttcctctcaaaggTgctggttcttcgtaacctgg	10	11	2	0			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr9:112015778T>C	uc004bdz.1	-	12	1517	c.1222A>G	c.(1222-1224)ACC>GCC	p.T408A	EPB41L4B_uc004bea.2_Missense_Mutation_p.T408A	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	408						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						CTCTCAAAGGTGCTGGTTCTT	0.403													C	112015778	C	C	112015778	3	2	214	1	0	0	0	0	1	0	0	0	5156	1696	59	4	1692	4	EPB41L4B	9	112015778	Missense_Mutation	SNP	T	TCGA-28-5214-01A-01D-1486-08	39012982	112015778	29197653	37	15061											
MAP3K11	4296	broad.mit.edu	37	chr11	65367001	65367001	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagatgagcggggaagggggCggctcggtcgggcagggcgc	23	9	0	2	rs138509783		TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr11:65367001C>A	uc001oew.2	-	9	2563	c.2070G>T	c.(2068-2070)CCG>CCT	p.P690P	MAP3K11_uc001oev.2_Silent_p.P106P|MAP3K11_uc010rol.1_Silent_p.P433P|MAP3K11_uc001oex.1_Silent_p.P197P	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	690	Pro-rich.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						GGGAAGGGGGCGGCTCGGTCG	0.736													A	65367001	A	A	65367001	2	1	214	1	0	0	0	0	0	0	0	1	9245	755	27	5		5	MAP3K11	11	65367001	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08		65367001	69639515	38	15062											
ANKRD33	341405	broad.mit.edu	37	chr12	52284680	52284680	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgccacaaccagcctggccaGtcccttcgtcaccactgcct	7	19	1	0			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr12:52284680G>C	uc001rzf.3	+	5	1154	c.575G>C	c.(574-576)AGT>ACT	p.S192T	ANKRD33_uc001rzh.3_3'UTR|ANKRD33_uc001rzd.2_Missense_Mutation_p.S317T|ANKRD33_uc001rze.2_Missense_Mutation_p.S213T|ANKRD33_uc001rzg.3_Missense_Mutation_p.S119T|ANKRD33_uc001rzi.3_Missense_Mutation_p.S192T	NM_001130015	NP_001123487	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33 isoform 1	192											0				BRCA - Breast invasive adenocarcinoma(357;0.0969)		AGCCTGGCCAGTCCCTTCGTC	0.632													C	52284680	C	C	52284680	3	2	214	1	0	0	0	0	1	0	0	0	661	1029	36	5	998	5	ANKRD33	12	52284680	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08		52284680	81567215	39	15063											
PAN2	9924	broad.mit.edu	37	chr12	56717611	56717611	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgtgggctggtacttttcacAggtgtcacaccaggcctgtg	13	11	2	0			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr12:56717611A>T	uc001skx.2	-	14	2537	c.2164T>A	c.(2164-2166)TGT>AGT	p.C722S	PAN2_uc001skw.2_5'UTR|PAN2_uc001skz.2_Missense_Mutation_p.C721S|PAN2_uc001sky.2_Missense_Mutation_p.C718S	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	722					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TACTTTTCACAGGTGTCACAC	0.522													T	56717611	T	T	56717611	3	4	214	1	0	0	0	0	1	0	0	0	11414	188	7	5	1496	5	PAN2	12	56717611	Missense_Mutation	SNP	A	TCGA-28-5214-01A-01D-1486-08	4432931	56717611	77134284	40	15064											
FGD6	55785	broad.mit.edu	37	chr12	95603097	95603097	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggcctgtggtggtgtctcCgagttggctactcttggacc	15	10	2	0			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr12:95603097C>T	uc001tdp.3	-	2	2187	c.1963G>A	c.(1963-1965)GGA>AGA	p.G655R	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	655					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						GTGGTGTCTCCGAGTTGGCTA	0.443													T	95603097	T	T	95603097	3	4	214	1	0	0	0	0	1	0	0	0	5837	661	23	2	2409	2	FGD6	12	95603097	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	38885486	95603097	38248798	41	15065											
MIPEP	4285	broad.mit.edu	37	chr13	24330744	24330744	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcatctccctgcgatagcGctccccggcagccctgggga	12	17	1	0	rs148780512	byFrequency	TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr13:24330744G>A	uc001uox.3	-	18	2084	c.1984C>T	c.(1984-1986)CGC>TGC	p.R662C		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	662					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		CTGCGATAGCGCTCCCCGGCA	0.517													A	24330744	A	A	24330744	3	1	214	1	0	0	0	0	1	0	0	0	9592	1087	38	1	165	1	MIPEP	13	24330744	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08		24330744	90839134	42	15066											
FMN1	342184	broad.mit.edu	37	chr15	33359642	33359642	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggccaccatcatcagagtcAgaatcactggtggtgtgcac	11	11	4	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr15:33359642A>G	uc001zhf.3	-	1	444	c.444T>C	c.(442-444)TCT>TCC	p.S148S	FMN1_uc001zhg.2_Silent_p.S148S	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:Variant_position_missing_in_Q68DA7_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CATCAGAGTCAGAATCACTGG	0.522													G	33359642	G	G	33359642	2	3	214	1	0	0	0	0	0	0	0	1	5949	175	7	4		4	FMN1	15	33359642	Silent	SNP	A	TCGA-28-5214-01A-01D-1486-08		33359642	69171750	43	15067											
SPATA5L1	79029	broad.mit.edu	37	chr15	45709546	45709546	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgttagatactgctttgttAcgacctggaagattagataa	10	5	0	3			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr15:45709546A>G	uc001zve.2	+	6	2026	c.1917A>G	c.(1915-1917)TTA>TTG	p.L639L	SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	639						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		CTGCTTTGTTACGACCTGGAA	0.393													G	45709546	G	G	45709546	2	3	214	1	0	0	0	0	0	0	0	1	15011	388	14	4		4	SPATA5L1	15	45709546	Silent	SNP	A	TCGA-28-5214-01A-01D-1486-08	12349904	45709546	56821846	44	15068											
VPS13C	54832	broad.mit.edu	37	chr15	62182532	62182532	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaaaagcaaaactctctggCgcccatccagaaatgatacc	7	12	1	3	rs150364963		TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr15:62182532C>T	uc002agz.2	-	67	9247	c.9173G>A	c.(9172-9174)CGC>CAC	p.R3058H	VPS13C_uc002aha.2_Missense_Mutation_p.R3015H|VPS13C_uc002ahb.1_Missense_Mutation_p.R3058H|VPS13C_uc002ahc.1_Missense_Mutation_p.R3015H	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3058					protein localization					ovary(2)	2						AACTCTCTGGCGCCCATCCAG	0.443													T	62182532	T	T	62182532	3	4	214	1	0	0	0	0	1	0	0	0	17188	768	27	1	2192	1	VPS13C	15	62182532	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	16472986	62182532	40348860	45	15069											
NR2F2	7026	broad.mit.edu	37	chr15	96877739	96877739	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgcctttatggaccacataCggatcttccaagagcaagtg	9	11	1	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr15:96877739C>T	uc010uri.1	+	2	2101	c.877C>T	c.(877-879)CGG>TGG	p.R293W	NR2F2_uc002btp.2_Missense_Mutation_p.R160W|NR2F2_uc010urj.1_Missense_Mutation_p.R140W|NR2F2_uc010urk.1_Missense_Mutation_p.R140W	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	293	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			GGACCACATACGGATCTTCCA	0.627													T	96877739	T	T	96877739	3	4	214	1	0	0	0	0	1	0	0	0	10628	527	19	1	930	1	NR2F2	15	96877739	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	34695207	96877739	5653653	46	15070											
FOXN1	8456	broad.mit.edu	37	chr17	26864328	26864328	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcagtggtggctccggggcActgggtgacctgcacctcac	16	13	1	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr17:26864328A>C	uc010crm.2	+	9	2019	c.1821A>C	c.(1819-1821)GCA>GCC	p.A607A	FOXN1_uc002hbj.2_Silent_p.A607A	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	607					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					GCTCCGGGGCACTGGGTGACC	0.687													C	26864328	C	C	26864328	2	2	214	1	0	0	0	0	0	0	0	1	6019	146	6	5		5	FOXN1	17	26864328	Silent	SNP	A	TCGA-28-5214-01A-01D-1486-08		26864328	54330882	47	15071											
GJC1	10052	broad.mit.edu	37	chr17	42882434	42882434	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggtcccaaaccctaaatgaAgcatctcccaaatgttaagc	6	12	1	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr17:42882434A>G	uc002ihj.2	-	2	1263	c.752T>C	c.(751-753)CTT>CCT	p.L251P	GJC1_uc002ihk.2_Missense_Mutation_p.L251P|GJC1_uc002ihl.2_Missense_Mutation_p.L251P|GJC1_uc010czx.2_Missense_Mutation_p.L251P|GJC1_uc010czy.1_Missense_Mutation_p.L112P	NM_005497	NP_005488	P36383	CXG1_HUMAN	connexin 45	251	Cytoplasmic (Potential).				cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane					0		Prostate(33;0.0959)				CCCTAAATGAAGCATCTCCCA	0.413													G	42882434	G	G	42882434	3	3	214	1	0	0	0	0	1	0	0	0	6414	72	3	4	442	4	GJC1	17	42882434	Missense_Mutation	SNP	A	TCGA-28-5214-01A-01D-1486-08	16018106	42882434	38312776	48	15072											
MC4R	4160	broad.mit.edu	37	chr18	58039563	58039563	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagagaagtgtgcatcccaCggtgggtggagttcaccatg	15	9	1	1	rs142837166		TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr18:58039563C>T	uc002lie.1	-	1	439	c.20G>A	c.(19-21)CGT>CAT	p.R7H		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	7	Extracellular (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				GTGCATCCCACGGTGGGTGGA	0.537													T	58039563	T	T	58039563	3	4	214	1	0	0	0	0	1	0	0	0	9366	536	19	1	982	1	MC4R	18	58039563	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08		58039563	20037685	49	15073											
HDGFRP2	84717	broad.mit.edu	37	chr19	4475292	4475292	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcgacgacatcgcggatggCgccgtgaagcccccacccaa	11	16	0	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr19:4475292C>T	uc002mao.2	+	2	186	c.93C>T	c.(91-93)GGC>GGT	p.G31G	HDGFRP2_uc002map.2_Silent_p.G31G|HDGFRP2_uc010dtz.1_5'Flank	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	31	PWWP.				transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						TCGCGGATGGCGCCGTGAAGC	0.562													T	4475292	T	T	4475292	2	4	214	1	0	0	0	0	0	0	0	1	7020	755	27	1		1	HDGFRP2	19	4475292	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08		4475292	54653691	50	15074											
ZNF564	163050	broad.mit.edu	37	chr19	12638084	12638084	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acactgtttacattcatgggGtttctctccagtatgagttc	8	9	2	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr19:12638084G>A	uc002mty.2	-	4	1048	c.838C>T	c.(838-840)CCC>TCC	p.P280S	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	280					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATTCATGGGGTTTCTCTCCA	0.403													A	12638084	A	A	12638084	3	1	214	1	0	0	0	0	1	0	0	0	17992	1261	44	3	827	3	ZNF564	19	12638084	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	8162792	12638084	46490899	51	15075											
CCDC123	84902	broad.mit.edu	37	chr19	33406291	33406291	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaacttccactgcgattttgCcatccgagtgtgttttgagt	10	9	0	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr19:33406291C>T	uc002nty.2	-	14	1606	c.1517G>A	c.(1516-1518)GGC>GAC	p.G506D	CCDC123_uc002ntx.2_Missense_Mutation_p.G259D|CCDC123_uc010edg.2_RNA|CCDC123_uc002ntz.1_Missense_Mutation_p.G505D	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	506	Potential.					centrosome|spindle pole					0	Esophageal squamous(110;0.137)					TGCGATTTTGCCATCCGAGTG	0.358													T	33406291	T	T	33406291	3	4	214	1	0	0	0	0	1	0	0	0	2759	739	26	3	858	3	CCDC123	19	33406291	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	20768207	33406291	25722692	52	15076											
PSG9	5678	broad.mit.edu	37	chr19	43762524	43762524	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aatactctgccggtgggttaGattccgtgaagcaggacaag	13	8	1	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr19:43762524G>C	uc002owd.3	-	5	1172	c.1073C>G	c.(1072-1074)TCT>TGT	p.S358C	PSG9_uc002owe.3_Missense_Mutation_p.S265C|PSG9_uc010xwm.1_Missense_Mutation_p.S265C|PSG9_uc002owf.3_Missense_Mutation_p.S172C|PSG9_uc002owg.2_Missense_Mutation_p.S265C|PSG9_uc002owh.2_Missense_Mutation_p.S172C	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	358	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				CGGTGGGTTAGATTCCGTGAA	0.448													C	43762524	C	C	43762524	3	2	214	1	0	0	0	0	1	0	0	0	12662	942	33	5	215	5	PSG9	19	43762524	Missense_Mutation	SNP	G	TCGA-28-5214-01A-01D-1486-08	10356233	43762524	15366459	53	15077											
SYNGR4	23546	broad.mit.edu	37	chr19	48878966	48878966	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcctggggagcagcagtgCccaggcagccatcgccttca	12	16	1	0			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr19:48878966C>T	uc002piz.2	+	4	673	c.428C>T	c.(427-429)GCC>GTC	p.A143V		NM_012451	NP_036583	O95473	SNG4_HUMAN	synaptogyrin 4	143	MARVEL.					integral to membrane					0		all_epithelial(76;5.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|Prostate(7;0.0143)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		AGCAGCAGTGCCCAGGCAGCC	0.612													T	48878966	T	T	48878966	3	4	214	1	0	0	0	0	1	0	0	0	15448	739	26	3	438	3	SYNGR4	19	48878966	Missense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08	5116442	48878966	10250017	54	15078											
LILRA1	11024	broad.mit.edu	37	chr19	55106242	55106242	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acccaggagtaccgtctgtaTagagaaaagaaaacagcacc	9	10	1	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr19:55106242T>C	uc002qgh.1	+	4	365	c.183T>C	c.(181-183)TAT>TAC	p.Y61Y	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Silent_p.Y61Y	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	61	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		ACCGTCTGTATAGAGAAAAGA	0.577													C	55106242	C	C	55106242	2	2	214	1	0	0	0	0	0	0	0	1	8784	1413	49	4		4	LILRA1	19	55106242	Silent	SNP	T	TCGA-28-5214-01A-01D-1486-08	6227276	55106242	4022741	55	15079											
ISM1	140862	broad.mit.edu	37	chr20	13279761	13279761	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggacttccgctggaaggaCgccagcgggcccaaggagaa	15	11	0	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr20:13279761C>T	uc010gce.1	+	6	1056	c.1050C>T	c.(1048-1050)GAC>GAT	p.D350D	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	350	AMOP.					extracellular region					0						GCTGGAAGGACGCCAGCGGGC	0.647													T	13279761	T	T	13279761	2	4	214	1	0	0	0	0	0	0	0	1	7860	535	19	1		1	ISM1	20	13279761	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08		13279761	49745759	56	15080											
ZBTB46	140685	broad.mit.edu	37	chr20	62421878	62421878	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttgaagccctgggccgtgAcgatgtccaggtgcgtgacc	14	13	0	3			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chr20:62421878A>C	uc002ygv.1	-	2	434	c.233T>G	c.(232-234)GTC>GGC	p.V78G	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	78	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CTGGGCCGTGACGATGTCCAG	0.612													C	62421878	C	C	62421878	3	2	214	1	0	0	0	0	1	0	0	0	17544	275	10	5	1552	5	ZBTB46	20	62421878	Missense_Mutation	SNP	A	TCGA-28-5214-01A-01D-1486-08	49142117	62421878	603642	57	15081											
CDX4	1046	broad.mit.edu	37	chrX	72667327	72667327	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcaccctacagtcccccgCgagaagactggagcgtgtat	11	14	1	2			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chrX:72667327C>T	uc011mqk.1	+	1	238	c.238C>T	c.(238-240)CGA>TGA	p.R80*		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	80						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					CAGTCCCCCGCGAGAAGACTG	0.607													T	72667327	T	T	72667327	4	4	214	1	0	0	0	0	0	1	0	0	3184	760	27	1	240	1	CDX4	23	72667327	Nonsense_Mutation	SNP	C	TCGA-28-5214-01A-01D-1486-08		72667327	82603233	58	15082											
ATRX	546	broad.mit.edu	37	chrX	76918965	76918965	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcactcacagtcaatttgtgCcgcaaaagcctatgtctgta	7	11	4	0			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chrX:76918965C>T	uc004ecp.3	-	12	4258	c.4026G>A	c.(4024-4026)CGG>CGA	p.R1342R	ATRX_uc004ecq.3_Silent_p.R1304R|ATRX_uc004eco.3_Silent_p.R1127R|ATRX_uc004ecr.2_Silent_p.R1274R	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1342					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCAATTTGTGCCGCAAAAGCC	0.363			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						T	76918965	T	T	76918965	2	4	214	1	0	0	0	0	0	0	0	1	1208	726	26	3		3	ATRX	23	76918965	Silent	SNP	C	TCGA-28-5214-01A-01D-1486-08	4251638	76918965	78351595	59	15083											
MAGEA8	4107	broad.mit.edu	37	chrX	149013838	149013838	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctggagtaccgccaggcGcccggcagtgatcctgtgcg	14	14	0	1			TCGA-28-5214-01A-01D-1486-08	TCGA-28-5214-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c992e603-30c9-4e30-a425-8050189db4f8	c194cf39-9d59-4afe-9750-fe124ae94c68	g.chrX:149013838G>A	uc004fdw.1	+	3	1007	c.792G>A	c.(790-792)GCG>GCA	p.A264A		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	264	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					ACCGCCAGGCGCCCGGCAGTG	0.582													A	149013838	A	A	149013838	2	1	214	1	0	0	0	0	0	0	0	1	9171	1074	38	1		1	MAGEA8	23	149013838	Silent	SNP	G	TCGA-28-5214-01A-01D-1486-08	72094873	149013838	6256722	60	15084											
UBR4	23352	broad.mit.edu	37	chr1	19451182	19451182	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaaacacatcagcagcatgAccctgggagaagaaaatttg	9	9	2	3			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr1:19451182A>G	uc001bbi.2	-	65	9445	c.9441T>C	c.(9439-9441)GGT>GGC	p.G3147G	UBR4_uc001bbk.1_Silent_p.G794G	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3147					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAGCAGCATGACCCTGGGAGA	0.413													G	19451182	G	G	19451182	2	3	215	1	0	0	0	0	0	0	0	1	16901	262	10	4		4	UBR4	1	19451182	Silent	SNP	A	TCGA-28-5215-01A-01D-1486-08		19451182	229799439	1	15085											
SFN	2810	broad.mit.edu	37	chr1	27190037	27190037	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gccacctcatcaaggaggccGgggacgccgagagccgggtc	16	14	2	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr1:27190037G>T	uc001bnc.1	+	1	405	c.334G>T	c.(334-336)GGG>TGG	p.G112W	uc010ofi.1_RNA	NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	112					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		CAAGGAGGCCGGGGACGCCGA	0.637													T	27190037	T	T	27190037	3	4	215	1	0	0	0	0	1	0	0	0	14159	1116	39	5	336	5	SFN	1	27190037	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08	7738855	27190037	222060584	2	15086											
BCAR3	8412	broad.mit.edu	37	chr1	94032964	94032964	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cccacatgtcggttccttcaAaagtcacagcctggcgctcc	8	16	2	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr1:94032964A>G	uc001dpz.2	-	11	2446	c.2171T>C	c.(2170-2172)TTT>TCT	p.F724S	BCAR3_uc001dqa.2_Missense_Mutation_p.F724S|BCAR3_uc001dqb.2_Missense_Mutation_p.F724S|BCAR3_uc001dpx.3_Missense_Mutation_p.F400S|BCAR3_uc001dpy.2_Missense_Mutation_p.F633S	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	724	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		GGTTCCTTCAAAAGTCACAGC	0.502													G	94032964	G	G	94032964	3	3	215	1	0	0	0	0	1	0	0	0	1349	14	1	4	314	4	BCAR3	1	94032964	Missense_Mutation	SNP	A	TCGA-28-5215-01A-01D-1486-08	66842927	94032964	155217657	3	15087											
IRF6	3664	broad.mit.edu	37	chr1	209961847	209961847	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcctgggtttgaaggatgCggtacagctgcttcagctga	13	9	2	2			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr1:209961847C>T	uc001hhq.1	-	9	1585	c.1322G>A	c.(1321-1323)CGC>CAC	p.R441H	IRF6_uc010psm.1_Missense_Mutation_p.R346H|IRF6_uc009xct.1_Missense_Mutation_p.R441H	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	441					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		TTGAAGGATGCGGTACAGCTG	0.557										HNSCC(57;0.16)			T	209961847	T	T	209961847	3	4	215	1	0	0	0	0	1	0	0	0	7834	768	27	1	85	1	IRF6	1	209961847	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08	115928883	209961847	39288774	4	15088											
ST6GAL2	84620	broad.mit.edu	37	chr2	107459661	107459661	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcgtccgcacgcgcgcgCggctccgcagctggcacagc	14	19	0	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr2:107459661C>T	uc002tdq.2	-	2	892	c.773G>A	c.(772-774)CGC>CAC	p.R258H	ST6GAL2_uc002tdr.2_Missense_Mutation_p.R258H|ST6GAL2_uc002tds.3_Missense_Mutation_p.R258H	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	258	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CACGCGCGCGCGGCTCCGCAG	0.736													T	107459661	T	T	107459661	3	4	215	1	0	0	0	0	1	0	0	0	15221	768	27	1	923	1	ST6GAL2	2	107459661	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08		107459661	135739712	5	15089											
PSD4	23550	broad.mit.edu	37	chr2	113950118	113950118	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttggcctcacgcctctatcGcctggagggcttccggaagt	12	14	2	0	rs140435814	byFrequency	TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr2:113950118G>A	uc002tjc.2	+	6	1973	c.1790G>A	c.(1789-1791)CGC>CAC	p.R597H	PSD4_uc002tjd.2_Missense_Mutation_p.R218H|PSD4_uc002tje.2_Missense_Mutation_p.R568H|PSD4_uc002tjf.2_Missense_Mutation_p.R218H	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	597	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CGCCTCTATCGCCTGGAGGGC	0.597													A	113950118	A	A	113950118	3	1	215	1	0	0	0	0	1	0	0	0	12649	1087	38	1	1808	1	PSD4	2	113950118	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08	6490457	113950118	129249255	6	15090											
INPP5D	3635	broad.mit.edu	37	chr2	234112804	234112804	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggaagaacgcaggggacaCgctgcctcaggaggacctgc	17	11	1	1	rs142742228	by1000genomes	TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr2:234112804C>T	uc010zmo.1	+	25	3161	c.3008C>T	c.(3007-3009)ACG>ATG	p.T1003M	INPP5D_uc010zmp.1_Missense_Mutation_p.T1002M	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	1003	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GCAGGGGACACGCTGCCTCAG	0.517													T	234112804	T	T	234112804	3	4	215	1	0	0	0	0	1	0	0	0	7756	536	19	1	2618	1	INPP5D	2	234112804	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08	120162686	234112804	9086569	7	15091											
TRIM71	131405	broad.mit.edu	37	chr3	32933302	32933302	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caatcgaatcctcgtcttctAattgcatttcctaggtttct	5	11	3	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr3:32933302A>G	uc003cff.2	+	4	2669	c.2606A>G	c.(2605-2607)TAA>TGA	p.*869*		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	869					multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						CTCGTCTTCTAATTGCATTTC	0.408													G	32933302	G	G	32933302	2	3	215	1	0	0	0	0	0	0	0	1	16541	369	13	4		4	TRIM71	3	32933302	Silent	SNP	A	TCGA-28-5215-01A-01D-1486-08		32933302	165089128	8	15092											
SI	6476	broad.mit.edu	37	chr3	164733001	164733001	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcagggtaagtctttgtttcAtttcctgaaattgctggatc	10	7	2	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr3:164733001A>G	uc003fei.2	-	33	3971	c.3909T>C	c.(3907-3909)AAT>AAC	p.N1303N		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1303	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCTTTGTTTCATTTCCTGAAA	0.348										HNSCC(35;0.089)			G	164733001	G	G	164733001	2	3	215	1	0	0	0	0	0	0	0	1	14297	214	8	4		4	SI	3	164733001	Silent	SNP	A	TCGA-28-5215-01A-01D-1486-08	131799699	164733001	33289429	9	15093											
NDST4	64579	broad.mit.edu	37	chr4	115998231	115998231	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaagctttttcccaatttcGtttcctaaagtgccatagtg	8	9	0	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr4:115998231G>A	uc003ibu.2	-	2	641	c.-38C>T	c.(-40--36)AACGA>AATGA		NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase							Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TCCCAATTTCGTTTCCTAAAG	0.338													A	115998231	A	A	115998231	1	1	215	1	0	0	0	0	0	0	0	0	10258	1160	40	1		1	NDST4	4	115998231	Translation_Start_Site	SNP	G	TCGA-28-5215-01A-01D-1486-08		115998231	75156045	10	15094											
TRIML2	205860	broad.mit.edu	37	chr4	189012730	189012730	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgcagtcaaggaaaacgcCaactgtgtccaacttctttt	7	11	2	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr4:189012730C>T	uc003izl.2	-	7	997	c.961G>A	c.(961-963)GGG>AGG	p.G321R	TRIML2_uc003izj.1_Missense_Mutation_p.G149S|TRIML2_uc003izk.1_Missense_Mutation_p.G129S|TRIML2_uc011cle.1_Missense_Mutation_p.G396S	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	321	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		AGGAAAACGCCAACTGTGTCC	0.517													T	189012730	T	T	189012730	3	4	215	1	0	0	0	0	1	0	0	0	16548	594	21	3	206	3	TRIML2	4	189012730	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08	73014499	189012730	2141546	11	15095											
ADAMTS6	11174	broad.mit.edu	37	chr5	64520167	64520167	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caatatagttctttgacatgGcaacttctctaacttcaatg	5	9	3	1	rs143194045		TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr5:64520167G>A	uc003jtp.2	-	18	3066	c.2252C>T	c.(2251-2253)GCC>GTC	p.A751V	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Missense_Mutation_p.A372V	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	751	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CTTTGACATGGCAACTTCTCT	0.408													A	64520167	A	A	64520167	3	1	215	1	0	0	0	0	1	0	0	0	270	1203	42	3	1133	3	ADAMTS6	5	64520167	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08		64520167	116395093	12	15096											
PCDHA2	56146	broad.mit.edu	37	chr5	140176553	140176553	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acggccaccgtgttagtgtcGttggtggaaagtggccaggc	16	9	0	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr5:140176553G>A	uc003lhd.2	+	1	2110	c.2004G>A	c.(2002-2004)TCG>TCA	p.S668S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.S668S|PCDHA2_uc011czy.1_Silent_p.S668S	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	668	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTAGTGTCGTTGGTGGAAA	0.652													A	140176553	A	A	140176553	2	1	215	1	0	0	0	0	0	0	0	1	11524	1132	40	1		1	PCDHA2	5	140176553	Silent	SNP	G	TCGA-28-5215-01A-01D-1486-08	75656386	140176553	40738707	13	15097											
TRIM26	7726	broad.mit.edu	37	chr6	30164404	30164404	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaacttctccctgccctcCgtgagctcctgctccagctt	7	17	1	2	rs137972961		TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr6:30164404C>T	uc003npr.2	-	5	863	c.654G>A	c.(652-654)ACG>ACA	p.T218T	TRIM26_uc003nps.2_Silent_p.T218T|TRIM26_uc010jry.2_5'UTR|TRIM26_uc003npt.2_Silent_p.T218T	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	218	Potential.						DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CCCTGCCCTCCGTGAGCTCCT	0.642													T	30164404	T	T	30164404	2	4	215	1	0	0	0	0	0	0	0	1	16497	639	23	2		2	TRIM26	6	30164404	Silent	SNP	C	TCGA-28-5215-01A-01D-1486-08		30164404	140950663	14	15098											
SIM1	6492	broad.mit.edu	37	chr6	100911318	100911318	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttctccctcctagtccgCgcagcatttttggacttttc	6	15	1	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr6:100911318C>T	uc003pqj.3	-	1	234	c.27G>A	c.(25-27)GCG>GCA	p.A9A	SIM1_uc010kcu.2_Silent_p.A9A	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	9	Basic motif.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TCCTAGTCCGCGCAGCATTTT	0.423													T	100911318	T	T	100911318	2	4	215	1	0	0	0	0	0	0	0	1	14323	755	27	1		1	SIM1	6	100911318	Silent	SNP	C	TCGA-28-5215-01A-01D-1486-08	70746914	100911318	70203749	15	15099											
FNDC1	84624	broad.mit.edu	37	chr6	159655381	159655381	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgggcacccacccctggccGcagtacaccacgcgcgcccc	11	22	0	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr6:159655381G>A	uc010kjv.2	+	11	4037	c.3837G>A	c.(3835-3837)CCG>CCA	p.P1279P	FNDC1_uc010kjw.1_Silent_p.P1164P	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1279						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		ACCCCTGGCCGCAGTACACCA	0.701													A	159655381	A	A	159655381	2	1	215	1	0	0	0	0	0	0	0	1	5968	1074	38	1		1	FNDC1	6	159655381	Silent	SNP	G	TCGA-28-5215-01A-01D-1486-08	58744063	159655381	11459686	16	15100											
CHN2	1124	broad.mit.edu	37	chr7	29438049	29438049	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttggaggcgtggagggtgcCtacatccttagagaaagcca	14	9	0	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr7:29438049C>T	uc003szz.2	+	5	674	c.237C>T	c.(235-237)GCC>GCT	p.A79A	CHN2_uc011jzs.1_Silent_p.A154A|CHN2_uc010kva.2_Intron|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Silent_p.A44A|CHN2_uc011jzt.1_Silent_p.A92A|CHN2_uc010kvd.2_Intron|CHN2_uc011jzu.1_Silent_p.A64A	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	79	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						TGGAGGGTGCCTACATCCTTA	0.522													T	29438049	T	T	29438049	2	4	215	1	0	0	0	0	0	0	0	1	3363	668	24	3		3	CHN2	7	29438049	Silent	SNP	C	TCGA-28-5215-01A-01D-1486-08		29438049	129700614	17	15101											
ASB4	51666	broad.mit.edu	37	chr7	95115358	95115358	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agaaatttccttgaggcgctAaagtccaatgacttcggaaa	9	8	0	3			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr7:95115358A>G	uc011kij.1	+	1	75	c.75A>G	c.(73-75)CTA>CTG	p.L25L	ASB4_uc003unx.2_Silent_p.L25L	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	25					intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			TTGAGGCGCTAAAGTCCAATG	0.438													G	95115358	G	G	95115358	2	3	215	1	0	0	0	0	0	0	0	1	1025	349	13	4		4	ASB4	7	95115358	Silent	SNP	A	TCGA-28-5215-01A-01D-1486-08	65677309	95115358	64023305	18	15102											
ANK1	286	broad.mit.edu	37	chr8	41566469	41566469	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctggttctgcttggcagCgatgtgcaaaggggtgtagc	15	9	1	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr8:41566469C>T	uc003xok.2	-	17	1909	c.1825G>A	c.(1825-1827)GCT>ACT	p.A609T	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_5'Flank|ANK1_uc003xoi.2_Missense_Mutation_p.A609T|ANK1_uc003xoj.2_Missense_Mutation_p.A609T|ANK1_uc003xol.2_Missense_Mutation_p.A609T|ANK1_uc003xom.2_Missense_Mutation_p.A642T	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	609	ANK 18.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton	p.A609T(1)		ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGCTTGGCAGCGATGTGCAAA	0.582													T	41566469	T	T	41566469	3	4	215	1	0	0	0	0	1	0	0	0	620	768	27	1	4278	1	ANK1	8	41566469	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08		41566469	104797553	19	15103											
ATP6V0D2	245972	broad.mit.edu	37	chr8	87162356	87162356	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcagtttgaggccgacagaCgtgcttttatcatcactctt	8	10	4	2			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr8:87162356C>T	uc003ydp.1	+	6	724	c.655C>T	c.(655-657)CGT>TGT	p.R219C		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	219					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						GGCCGACAGACGTGCTTTTAT	0.408													T	87162356	T	T	87162356	3	4	215	1	0	0	0	0	1	0	0	0	1174	536	19	1	677	1	ATP6V0D2	8	87162356	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08	45595887	87162356	59201666	20	15104											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18777555	18777555	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctggcccaggagatcttcCgcagccacctggagcaccag	12	15	1	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr9:18777555C>T	uc003zne.3	+	19	3455	c.3328C>T	c.(3328-3330)CGC>TGC	p.R1110C		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1110						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GGAGATCTTCCGCAGCCACCT	0.647													T	18777555	T	T	18777555	3	4	215	1	0	0	0	0	1	0	0	0	274	652	23	2	3406	2	ADAMTSL1	9	18777555	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08		18777555	122435876	21	15105											
CDH23	64072	broad.mit.edu	37	chr10	73375274	73375274	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cttgcagggaataccaacagCatctttgccctggactacat	8	12	1	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr10:73375274C>G	uc001jrx.3	+	10	1223	c.846C>G	c.(844-846)AGC>AGG	p.S282R	CDH23_uc001jrw.3_Missense_Mutation_p.S282R|CDH23_uc009xql.2_Missense_Mutation_p.S327R	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	282	Cadherin 3.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						ATACCAACAGCATCTTTGCCC	0.607													G	73375274	G	G	73375274	3	3	215	1	0	0	0	0	1	0	0	0	3108	709	25	5	880	5	CDH23	10	73375274	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08		73375274	62159473	22	15106											
DHX32	55760	broad.mit.edu	37	chr10	127541113	127541113	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttgtgtccacagcactaccTgaagaagatgagccaagaat	9	9	0	5			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr10:127541113T>C	uc001ljf.1	-	5	1682	c.1191A>G	c.(1189-1191)TCA>TCG	p.S397S	BCCIP_uc001ljd.3_Intron|DHX32_uc001lje.1_Silent_p.S21S|DHX32_uc001ljg.1_Silent_p.S397S|DHX32_uc009yam.1_Silent_p.S152S	NM_018180	NP_060650	Q7L7V1	DHX32_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32	397						mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				CAGCACTACCTGAAGAAGATG	0.433													C	127541113	C	C	127541113	2	2	215	1	0	0	0	0	0	0	0	1	4505	1594	55	4		4	DHX32	10	127541113	Silent	SNP	T	TCGA-28-5215-01A-01D-1486-08	54165839	127541113	7993634	23	15107											
PNPLA2	57104	broad.mit.edu	37	chr11	824015	824015	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagccctgctggaggcctgcGtggagcccacggacctgctg	15	15	0	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr11:824015G>A	uc001lrt.2	+	8	1139	c.937G>A	c.(937-939)GTG>ATG	p.V313M	PNPLA2_uc009ycl.2_Missense_Mutation_p.R124H|EFCAB4A_uc010qwt.1_5'Flank	NM_020376	NP_065109	Q96AD5	PLPL2_HUMAN	patatin-like phospholipase domain containing 2	313	Lumenal (Potential).				negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process	integral to membrane|lipid particle|plasma membrane	triglyceride lipase activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.63e-25)|Epithelial(43;1.28e-24)|OV - Ovarian serous cystadenocarcinoma(40;7.09e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAGGCCTGCGTGGAGCCCAC	0.637													A	824015	A	A	824015	3	1	215	1	0	0	0	0	1	0	0	0	12165	1145	40	1	963	1	PNPLA2	11	824015	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08		824015	134182501	24	15108											
OR5D16	390144	broad.mit.edu	37	chr11	55606777	55606777	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atcatttcttctgtgagttaTcctccctgatatcactctct	4	12	5	2			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr11:55606777T>C	uc010rio.1	+	1	550	c.550T>C	c.(550-552)TCC>CCC	p.S184P		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				CTGTGAGTTATCCTCCCTGAT	0.418													C	55606777	C	C	55606777	3	2	215	1	0	0	0	0	1	0	0	0	11156	1435	50	4	552	4	OR5D16	11	55606777	Missense_Mutation	SNP	T	TCGA-28-5215-01A-01D-1486-08	54782762	55606777	79399739	25	15109											
UVRAG	7405	broad.mit.edu	37	chr11	75852116	75852116	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	accctagccaagaacaaggaGaagccctctccgggcaccgg	11	15	1	2			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr11:75852116G>T	uc001oxc.2	+	15	2000	c.1759G>T	c.(1759-1761)GAA>TAA	p.E587*	UVRAG_uc010rrw.1_Nonsense_Mutation_p.E486*|UVRAG_uc001oxd.2_Nonsense_Mutation_p.E215*|UVRAG_uc010rrx.1_Nonsense_Mutation_p.E215*|UVRAG_uc010rry.1_Nonsense_Mutation_p.E143*	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	587					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						AGAACAAGGAGAAGCCCTCTC	0.577													T	75852116	T	T	75852116	4	4	215	1	0	0	0	0	0	1	0	0	17105	943	33	5	1817	5	UVRAG	11	75852116	Nonsense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08	20245339	75852116	59154400	26	15110											
RACGAP1	29127	broad.mit.edu	37	chr12	50387942	50387942	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tccataaaggctctgttaagGcgaaaggtcagaagaggttc	12	7	2	2			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr12:50387942G>C	uc001rvt.2	-	14	1621	c.1311C>G	c.(1309-1311)CGC>CGG	p.R437R	RACGAP1_uc009zlm.1_Silent_p.R437R|RACGAP1_uc001rvs.2_Silent_p.R437R|RACGAP1_uc001rvu.2_Silent_p.R437R	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	437	Rho-GAP.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						CTCTGTTAAGGCGAAAGGTCA	0.318													C	50387942	C	C	50387942	2	2	215	1	0	0	0	0	0	0	0	1	12977	1190	42	5		5	RACGAP1	12	50387942	Silent	SNP	G	TCGA-28-5215-01A-01D-1486-08		50387942	83463953	27	15111											
LRP1	4035	broad.mit.edu	37	chr12	57571370	57571370	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgcatcctttggattgacGccaggtcagcaccctctgtg	11	13	2	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr12:57571370G>A	uc001snd.2	+	26	4823	c.4357G>A	c.(4357-4359)GCC>ACC	p.A1453T		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1453	Extracellular (Potential).|LDL-receptor class B 11.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTGGATTGACGCCAGGTCAGC	0.657													A	57571370	A	A	57571370	3	1	215	1	0	0	0	0	1	0	0	0	8951	1087	38	1	4459	1	LRP1	12	57571370	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08	7183428	57571370	76280525	28	15112											
CLIP1	6249	broad.mit.edu	37	chr12	122839754	122839754	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccgccctctccagatcccGttccgccagcagctgctcaa	7	20	2	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr12:122839754G>A	uc001ucg.1	-	5	1217	c.1111C>T	c.(1111-1113)CGG>TGG	p.R371W	CLIP1_uc001uch.1_Missense_Mutation_p.R371W|CLIP1_uc001uci.1_Missense_Mutation_p.R371W|CLIP1_uc001ucj.1_Missense_Mutation_p.R72W|CLIP1_uc009zxo.1_5'Flank|CLIP1_uc010tae.1_Intron	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	371	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TCCAGATCCCGTTCCGCCAGC	0.632													A	122839754	A	A	122839754	3	1	215	1	0	0	0	0	1	0	0	0	3532	1144	40	1	3252	1	CLIP1	12	122839754	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08	65268384	122839754	11012141	29	15113											
TMEM132D	121256	broad.mit.edu	37	chr12	129694161	129694161	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagaccactttcaccgggacGgccaccgtcttccccgtgag	11	16	2	2			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr12:129694161G>A	uc009zyl.1	-	5	1675	c.1347C>T	c.(1345-1347)GCC>GCT	p.A449A		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	449	Extracellular (Potential).					integral to membrane		p.A449V(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCACCGGGACGGCCACCGTCT	0.572													A	129694161	A	A	129694161	2	1	215	1	0	0	0	0	0	0	0	1	16044	1103	39	2		2	TMEM132D	12	129694161	Silent	SNP	G	TCGA-28-5215-01A-01D-1486-08	6854407	129694161	4157734	30	15114											
OR6S1	341799	broad.mit.edu	37	chr14	21109809	21109809	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttgggagccctgccaggacGaactctgttggatcactact	11	11	2	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr14:21109809G>A	uc001vxv.1	-	1	42	c.42C>T	c.(40-42)TTC>TTT	p.F14F		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		CTGCCAGGACGAACTCTGTTG	0.453													A	21109809	A	A	21109809	2	1	215	1	0	0	0	0	0	0	0	1	11209	1049	37	2		2	OR6S1	14	21109809	Silent	SNP	G	TCGA-28-5215-01A-01D-1486-08		21109809	86239731	31	15115											
VPS18	57617	broad.mit.edu	37	chr15	41191139	41191139	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcaaatgagcccaaccacGtggagctgggacgtaaggat	14	9	0	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr15:41191139G>A	uc001zne.2	+	3	607	c.268G>A	c.(268-270)GTG>ATG	p.V90M		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	90					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GCCCAACCACGTGGAGCTGGG	0.448													A	41191139	A	A	41191139	3	1	215	1	0	0	0	0	1	0	0	0	17191	1145	40	1	278	1	VPS18	15	41191139	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08		41191139	61340253	32	15116											
SLC30A4	7782	broad.mit.edu	37	chr15	45814527	45814527	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttagcatagatttgaggCgcttccacgcgccagagccg	11	13	0	3			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr15:45814527C>T	uc001zvj.2	-	2	338	c.26G>A	c.(25-27)CGC>CAC	p.R9H	C15orf21_uc010beg.1_Intron|C15orf21_uc010beh.1_Intron|C15orf21_uc010bei.1_Intron|C15orf21_uc010bej.1_Intron|C15orf21_uc001zvm.1_Intron|C15orf21_uc001zvn.1_Intron	NM_013309	NP_037441	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter),	9	Cytoplasmic (Potential).				regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		AGATTTGAGGCGCTTCCACGC	0.652													T	45814527	T	T	45814527	3	4	215	1	0	0	0	0	1	0	0	0	14557	768	27	1	1291	1	SLC30A4	15	45814527	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08	4623388	45814527	56716865	33	15117											
SHCBP1	79801	broad.mit.edu	37	chr16	46615749	46615749	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgtcatcagcttgcgtgatCcccagttcactcaacctttt	6	13	4	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr16:46615749C>T	uc002eec.3	-	13	1951	c.1911G>A	c.(1909-1911)GGG>GGA	p.G637G		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	637										ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				CTTGCGTGATCCCCAGTTCAC	0.433													T	46615749	T	T	46615749	2	4	215	1	0	0	0	0	0	0	0	1	14274	842	30	3		3	SHCBP1	16	46615749	Silent	SNP	C	TCGA-28-5215-01A-01D-1486-08		46615749	43739004	34	15118											
TP53	7157	broad.mit.edu	37	chr17	7579312	7579312	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcccctcagggcaactgacCgtgcaagtcacagacttggc	11	14	2	2	rs55863639		TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr17:7579312C>T	uc002gim.2	-	4	569	c.375G>A	c.(373-375)ACG>ACA	p.T125T	TP53_uc002gig.1_Silent_p.T125T|TP53_uc002gih.2_Silent_p.T125T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Silent_p.T125T|TP53_uc010cni.1_Silent_p.T125T|TP53_uc002gij.2_Silent_p.T125T|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Silent_p.T86T|TP53_uc010cnk.1_Silent_p.T140T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	125	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in a sporadic cancer; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(15)|p.0?(7)|p.T125M(7)|p.T125K(3)|p.T125R(3)|p.?(2)|p.V73fs*9(1)|p.T125P(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.T125fs*45(1)|p.T125fs*24(1)|p.T125A(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7579312	T	T	7579312	2	4	215	1	0	0	0	0	0	0	0	1	16378	666	23	2		2	TP53	17	7579312	Silent	SNP	C	TCGA-28-5215-01A-01D-1486-08		7579312	73615898	35	15119											
MYH2	4620	broad.mit.edu	37	chr17	10432722	10432722	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tggattcttgggccaacttcAagtcaccctcaagtttcctc	7	13	4	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr17:10432722A>T	uc010coi.2	-	25	3322	c.3194T>A	c.(3193-3195)TTG>TAG	p.L1065*	uc002gml.1_Intron|MYH2_uc002gmp.3_Nonsense_Mutation_p.L1065*|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1065	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GGCCAACTTCAAGTCACCCTC	0.373													T	10432722	T	T	10432722	4	4	215	1	0	0	0	0	0	1	0	0	10035	131	5	5	2695	5	MYH2	17	10432722	Nonsense_Mutation	SNP	A	TCGA-28-5215-01A-01D-1486-08	2853410	10432722	70762488	36	15120											
NR1D1	9572	broad.mit.edu	37	chr17	38252312	38252312	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcaagcatccgctgcttctcTcgtttggggatgcgcccaaa	11	13	1	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr17:38252312T>C	uc002htz.1	-	5	1259	c.633A>G	c.(631-633)CGA>CGG	p.R211R	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_Intron	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	211					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					GCTGCTTCTCTCGTTTGGGGA	0.562													C	38252312	C	C	38252312	2	2	215	1	0	0	0	0	0	0	0	1	10615	1538	54	4		4	NR1D1	17	38252312	Silent	SNP	T	TCGA-28-5215-01A-01D-1486-08	27819590	38252312	42942898	37	15121											
KRT17	3872	broad.mit.edu	37	chr17	39780481	39780481	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtccaggtaggaggccaggCggtcattgaggttctgcatg	16	8	2	1	rs28928897		TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr17:39780481C>T	uc002hxh.2	-	1	402	c.281G>A	c.(280-282)CGC>CAC	p.R94H	JUP_uc010wfs.1_Intron|KRT17_uc010wft.1_Missense_Mutation_p.R94H	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	94	Coil 1A.|Rod.		R -> H (in SM).|R -> C (in PC2 and SM).|Missing (in PC2).|R -> P (in PC2).	Missing (in Ref. 5; AAH72018).	epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				GGAGGCCAGGCGGTCATTGAG	0.627									Steatocystoma_Multiplex				T	39780481	T	T	39780481	3	4	215	1	0	0	0	0	1	0	0	0	8454	768	27	1	1049	1	KRT17	17	39780481	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08	1528169	39780481	41414729	38	15122											
HELZ	9931	broad.mit.edu	37	chr17	65157047	65157047	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagaatatgtttgacagCctgagctagagtgaacgttt	11	7	0	5			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr17:65157047C>T	uc010wqk.1	-	16	2228	c.2041G>A	c.(2041-2043)GCT>ACT	p.A681T	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.A681T	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TGTTTGACAGCCTGAGCTAGA	0.493													T	65157047	T	T	65157047	3	4	215	1	0	0	0	0	1	0	0	0	7049	739	26	3	3859	3	HELZ	17	65157047	Missense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08	25376566	65157047	16038163	39	15123											
EPB41L3	23136	broad.mit.edu	37	chr18	5434010	5434010	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacattcatctgggtcatagTctccgagctctgactggaca	9	12	5	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr18:5434010T>C	uc002kmt.1	-	7	802	c.716A>G	c.(715-717)GAC>GGC	p.D239G	EPB41L3_uc010wzh.1_Missense_Mutation_p.D239G|EPB41L3_uc002kmu.1_Missense_Mutation_p.D239G|EPB41L3_uc010dkq.1_Missense_Mutation_p.D130G|EPB41L3_uc010dks.1_Missense_Mutation_p.D261G|EPB41L3_uc002kmv.1_Missense_Mutation_p.D130G	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	239	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TGGGTCATAGTCTCCGAGCTC	0.522													C	5434010	C	C	5434010	3	2	215	1	0	0	0	0	1	0	0	0	5154	1667	58	4	2611	4	EPB41L3	18	5434010	Missense_Mutation	SNP	T	TCGA-28-5215-01A-01D-1486-08		5434010	72643238	40	15124											
C19orf28	126321	broad.mit.edu	37	chr19	3547922	3547922	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tggcaggggccaacagggggGtgtgctcgcctggctcctcc	17	13	0	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr19:3547922G>C	uc002lxz.2	-	4	931	c.761C>G	c.(760-762)ACC>AGC	p.T254S	C19orf28_uc002lxw.2_Missense_Mutation_p.T254S|C19orf28_uc002lxx.2_Missense_Mutation_p.T254S|C19orf28_uc002lxy.2_Missense_Mutation_p.T245S	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	254					transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		CAACAGGGGGGTGTGCTCGCC	0.711													C	3547922	C	C	3547922	3	2	215	1	0	0	0	0	1	0	0	0	1917	1261	44	5	916	5	C19orf28	19	3547922	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08		3547922	55581061	41	15125											
CABIN1	23523	broad.mit.edu	37	chr22	24452748	24452748	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaaagcggcggtctgcccGtgtccgaaacaccaagtgca	12	13	1	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chr22:24452748G>A	uc002zzi.1	+	10	1314	c.1187G>A	c.(1186-1188)CGT>CAT	p.R396H	CABIN1_uc002zzj.1_Missense_Mutation_p.R346H|CABIN1_uc002zzl.1_Missense_Mutation_p.R396H|CABIN1_uc010guk.1_Missense_Mutation_p.R351H|CABIN1_uc002zzk.1_Missense_Mutation_p.R351H	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	396					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CGGTCTGCCCGTGTCCGAAAC	0.448													A	24452748	A	A	24452748	3	1	215	1	0	0	0	0	1	0	0	0	2528	1145	40	1	1221	1	CABIN1	22	24452748	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08		24452748	26851818	42	15126											
DCAF8L2	347442	broad.mit.edu	37	chrX	27765562	27765562	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagagacatctgccctgcccCgacctcgctggcaggtcgtt	11	16	1	1			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chrX:27765562C>T	uc011mjy.1	+	1	637	c.550C>T	c.(550-552)CGA>TGA	p.R184*		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						TGCCCTGCCCCGACCTCGCTG	0.612													T	27765562	T	T	27765562	4	4	215	1	0	0	0	0	0	1	0	0	4278	644	23	2	552	2	DCAF8L2	23	27765562	Nonsense_Mutation	SNP	C	TCGA-28-5215-01A-01D-1486-08		27765562	127504998	43	15127											
ZNF630	57232	broad.mit.edu	37	chrX	47918931	47918931	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	atgaggtgtgatttctcactGaaggctttcctacaatctcc	8	10	2	3			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chrX:47918931G>C	uc004div.3	-	5	1152	c.900C>G	c.(898-900)TTC>TTG	p.F300L	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.F176L	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	300	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						ATTTCTCACTGAAGGCTTTCC	0.413													C	47918931	C	C	47918931	3	2	215	1	0	0	0	0	1	0	0	0	18051	1281	45	5	1077	5	ZNF630	23	47918931	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08	20153369	47918931	107351629	44	15128											
DCX	1641	broad.mit.edu	37	chrX	110644549	110644549	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agttgtctgaggaacagacaTagctttcccctaaggcaaga	10	9	1	3			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chrX:110644549T>G	uc004epd.2	-	3	789	c.617A>C	c.(616-618)TAT>TCT	p.Y206S	DCX_uc011msv.1_Missense_Mutation_p.Y206S|DCX_uc004epe.2_Missense_Mutation_p.Y125S|DCX_uc004epf.2_Missense_Mutation_p.Y125S|DCX_uc004epg.2_Missense_Mutation_p.Y125S	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	206	Doublecortin 1.		Y -> H (in LISX1 and SBHX).|Y -> D (in SBHX).		axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						GGAACAGACATAGCTTTCCCC	0.378													G	110644549	G	G	110644549	3	3	215	1	0	0	0	0	1	0	0	0	4318	1406	49	5	743	5	DCX	23	110644549	Missense_Mutation	SNP	T	TCGA-28-5215-01A-01D-1486-08	62725618	110644549	44626011	45	15129											
AIFM1	9131	broad.mit.edu	37	chrX	129264005	129264005	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acaatccccacgaccactttGtccctgaggtagaagatgac	8	13	0	4			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chrX:129264005G>T	uc004evg.2	-	15	1888	c.1710C>A	c.(1708-1710)GAC>GAA	p.D570E	AIFM1_uc011mur.1_Missense_Mutation_p.D218E|AIFM1_uc011mus.1_3'UTR|AIFM1_uc004evh.2_Missense_Mutation_p.D566E|AIFM1_uc004evi.2_Missense_Mutation_p.D283E|AIFM1_uc004evk.2_RNA	NM_004208	NP_004199	O95831	AIFM1_HUMAN	programmed cell death 8 isoform 1	570					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			ovary(4)|central_nervous_system(1)	5						CGACCACTTTGTCCCTGAGGT	0.517													T	129264005	T	T	129264005	3	4	215	1	0	0	0	0	1	0	0	0	426	1368	48	5	139	5	AIFM1	23	129264005	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08	18619456	129264005	26006555	46	15130											
ATP6AP1	537	broad.mit.edu	37	chrX	153663708	153663708	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacagcaatggctccgtcGcctacttcaatgcttcccag	7	16	1	0			TCGA-28-5215-01A-01D-1486-08	TCGA-28-5215-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	34c77b5d-c3a6-4e83-96f4-fadd729362d9	0a812843-5ccb-4b1a-9507-22ebef53b113	g.chrX:153663708G>A	uc004flf.1	+	9	1121	c.1060G>A	c.(1060-1062)GCC>ACC	p.A354T	ATP6AP1_uc004flg.1_RNA|ATP6AP1_uc004flh.1_Missense_Mutation_p.A314T|GDI1_uc011mzo.1_5'Flank|GDI1_uc004fli.3_5'Flank	NM_001183	NP_001174	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory	354					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(3)|breast(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGGCTCCGTCGCCTACTTCAA	0.597													A	153663708	A	A	153663708	3	1	215	1	0	0	0	0	1	0	0	0	1165	1087	38	1	1094	1	ATP6AP1	23	153663708	Missense_Mutation	SNP	G	TCGA-28-5215-01A-01D-1486-08	24399703	153663708	1606852	47	15131											
ABCA4	24	broad.mit.edu	37	chr1	94512564	94512564	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcagacggtccacagctggCcggccacagggctcaaaaat	11	13	2	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr1:94512564C>T	uc001dqh.2	-	19	2933	c.2829G>A	c.(2827-2829)CGG>CGA	p.R943R	ABCA4_uc010otn.1_Silent_p.R869R	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	943	Cytoplasmic.|ABC transporter 1.		R -> W (in STGD1 and FFM).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CCACAGCTGGCCGGCCACAGG	0.522													T	94512564	T	T	94512564	2	4	216	1	0	0	0	0	0	0	0	1	34	726	26	3		3	ABCA4	1	94512564	Silent	SNP	C	TCGA-28-5216-01A-01D-1486-08		94512564	154738057	1	15132											
PSMD4	5710	broad.mit.edu	37	chr1	151237667	151237667	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaactggctaaacgcctcaAgaaggagaaagtaaatgttg	11	6	1	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr1:151237667A>G	uc001exl.2	+	5	457	c.395A>G	c.(394-396)AAG>AGG	p.K132R	PSMD4_uc001exn.2_Missense_Mutation_p.K132R	NM_002810	NP_002801	P55036	PSMD4_HUMAN	proteasome 26S non-ATPase subunit 4	132	VWFA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AAACGCCTCAAGAAGGAGAAA	0.453													G	151237667	G	G	151237667	3	3	216	1	0	0	0	0	1	0	0	0	12700	72	3	4	413	4	PSMD4	1	151237667	Missense_Mutation	SNP	A	TCGA-28-5216-01A-01D-1486-08	56725103	151237667	98012954	2	15133											
XCL1	6375	broad.mit.edu	37	chr1	168549318	168549318	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caggtgtagggagtgaagtcTcagataagaggacctgtgtg	16	5	1	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr1:168549318T>G	uc001gfo.1	+	2	99	c.79T>G	c.(79-81)TCA>GCA	p.S27A		NM_002995	NP_002986	P47992	XCL1_HUMAN	chemokine (C motif) ligand 1	27					CD4-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell proliferation|cell-cell signaling|cellular response to interleukin-4|cellular response to transforming growth factor beta stimulus|immunoglobulin production in mucosal tissue|lymphocyte chemotaxis|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell cytokine production|negative regulation of T-helper 1 cell activation|negative regulation of transcription, DNA-dependent|neutrophil chemotaxis|positive regulation of activated T cell proliferation|positive regulation of B cell chemotaxis|positive regulation of granzyme A production|positive regulation of granzyme B production|positive regulation of interleukin-10 production|positive regulation of natural killer cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell chemotaxis|positive regulation of T cell cytokine production|positive regulation of T cell mediated cytotoxicity|positive regulation of thymocyte migration|positive regulation of transforming growth factor-beta production|regulation of inflammatory response|release of sequestered calcium ion into cytosol|response to virus|T-helper 1 cell cytokine production|T-helper 2 cell cytokine production	extracellular space	chemokine activity|protein homodimerization activity				0	all_hematologic(923;0.208)					GAGTGAAGTCTCAGATAAGAG	0.433													G	168549318	G	G	168549318	3	3	216	1	0	0	0	0	1	0	0	0	17420	1551	54	5	85	5	XCL1	1	168549318	Missense_Mutation	SNP	T	TCGA-28-5216-01A-01D-1486-08	17311651	168549318	80701303	3	15134											
HHIPL2	79802	broad.mit.edu	37	chr1	222717273	222717273	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atcttgggccaccatgcccaGgtggcggttgagatagtcgt	14	10	1	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr1:222717273G>C	uc001hnh.1	-	2	638	c.580C>G	c.(580-582)CTG>GTG	p.L194V		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	194					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		ACCATGCCCAGGTGGCGGTTG	0.607													C	222717273	C	C	222717273	3	2	216	1	0	0	0	0	1	0	0	0	7094	991	35	5	1626	5	HHIPL2	1	222717273	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	54167955	222717273	26533348	4	15135											
GPN1	11321	broad.mit.edu	37	chr2	27861753	27861753	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgacttctctctggtacagaCtgacatcattgaccacagct	7	12	3	4			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr2:27861753C>T	uc010ymc.1	+	9	635	c.614C>T	c.(613-615)ACT>ATT	p.T205I	GPN1_uc010ezf.2_Missense_Mutation_p.T179I|GPN1_uc010yma.1_Missense_Mutation_p.T112I|GPN1_uc010ymb.1_Missense_Mutation_p.T96I|GPN1_uc010ymd.1_Missense_Mutation_p.T86I|GPN1_uc010yme.1_Missense_Mutation_p.T205I|GPN1_uc010ezg.1_Missense_Mutation_p.T86I	NM_007266	NP_009197	Q9HCN4	GPN1_HUMAN	GPN-loop GTPase 1 isoform a	191						cytoplasm	GTP binding|nucleoside-triphosphatase activity|protein binding				0						CTGGTACAGACTGACATCATT	0.393													T	27861753	T	T	27861753	3	4	216	1	0	0	0	0	1	0	0	0	6617	579	20	3	731	3	GPN1	2	27861753	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08		27861753	215337620	5	15136											
TTN	7273	broad.mit.edu	37	chr2	179496000	179496000	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctacaccagtataatcttgaAgttttcctgtaaaatatggg	7	7	1	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr2:179496000A>C	uc010zfg.1	-	186	36295	c.36071T>G	c.(36070-36072)CTT>CGT	p.L12024R	TTN_uc010zfh.1_Missense_Mutation_p.L5719R|TTN_uc010zfi.1_Missense_Mutation_p.L5652R|TTN_uc010zfj.1_Missense_Mutation_p.L5527R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12951							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAATCTTGAAGTTTTCCTGT	0.348													C	179496000	C	C	179496000	3	2	216	1	0	0	0	0	1	0	0	0	16732	72	3	5	64422	5	TTN	2	179496000	Missense_Mutation	SNP	A	TCGA-28-5216-01A-01D-1486-08	151634247	179496000	63703373	6	15137											
DNAH7	56171	broad.mit.edu	37	chr2	196753131	196753131	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ccagcctaacatgtgaggctCcatgtaaatcatgccacatc	7	13	1	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr2:196753131C>G	uc002utj.3	-	33	5358	c.5257G>C	c.(5257-5259)GAG>CAG	p.E1753Q		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1753	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATGTGAGGCTCCATGTAAATC	0.393													G	196753131	G	G	196753131	3	3	216	1	0	0	0	0	1	0	0	0	4606	864	30	5	6949	5	DNAH7	2	196753131	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08	17257131	196753131	46446242	7	15138											
ZDBF2	57683	broad.mit.edu	37	chr2	207171009	207171009	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgaaacaagttttgattgtgAtgtttctcttgagtcagtag	10	4	2	4			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr2:207171009A>G	uc002vbp.2	+	5	2007	c.1757A>G	c.(1756-1758)GAT>GGT	p.D586G		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	586							nucleic acid binding|zinc ion binding			ovary(3)	3						TTTGATTGTGATGTTTCTCTT	0.428													G	207171009	G	G	207171009	3	3	216	1	0	0	0	0	1	0	0	0	17596	333	12	4	1767	4	ZDBF2	2	207171009	Missense_Mutation	SNP	A	TCGA-28-5216-01A-01D-1486-08	10417878	207171009	36028364	8	15139											
ZNF860	344787	broad.mit.edu	37	chr3	32031844	32031844	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaatccataatgaagagagaTcttacaagtgtaataaatgt	8	4	1	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr3:32031844T>G	uc011axg.1	+	2	1822	c.1273T>G	c.(1273-1275)TCT>GCT	p.S425A		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAAGAGAGATCTTACAAGTG	0.348													G	32031844	G	G	32031844	3	3	216	1	0	0	0	0	1	0	0	0	18191	1435	50	5	1275	5	ZNF860	3	32031844	Missense_Mutation	SNP	T	TCGA-28-5216-01A-01D-1486-08		32031844	165990586	9	15140											
SETD2	29072	broad.mit.edu	37	chr3	47127761	47127761	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccacaacaaagacagcccaTgacgttccagaaaggacttc	7	13	0	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr3:47127761T>C	uc003cqs.2	-	11	5374	c.5321A>G	c.(5320-5322)CAT>CGT	p.H1774R	SETD2_uc003cqv.2_Missense_Mutation_p.H1841R|SETD2_uc003cqt.1_5'Flank	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1774					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AGACAGCCCATGACGTTCCAG	0.498			N|F|S|Mis		clear cell renal carcinoma								C	47127761	C	C	47127761	3	2	216	1	0	0	0	0	1	0	0	0	14131	1464	51	4	2417	4	SETD2	3	47127761	Missense_Mutation	SNP	T	TCGA-28-5216-01A-01D-1486-08	15095917	47127761	150894669	10	15141											
MST1	4485	broad.mit.edu	37	chr3	49723304	49723304	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggactcactgcggcttgtgCggcgtctcagcggaccagcg	16	13	2	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr3:49723304C>T	uc003cxg.2	-	10	1311	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	MST1_uc011bcs.1_Missense_Mutation_p.R452H	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	399	Kringle 4.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCGGCTTGTGCGGCGTCTCAG	0.682													T	49723304	T	T	49723304	2	4	216	1	0	0	0	0	0	0	0	1	9890	755	27	1		1	MST1	3	49723304	Silent	SNP	C	TCGA-28-5216-01A-01D-1486-08	2595543	49723304	148299126	11	15142											
SLMAP	7871	broad.mit.edu	37	chr3	57898233	57898233	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgctccttcatcaagcagcaGcaaaggttgcctctgagcgg	11	12	3	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr3:57898233G>T	uc003dje.1	+	18	1979	c.1774G>T	c.(1774-1776)GCA>TCA	p.A592S	SLMAP_uc003djd.1_Missense_Mutation_p.A575S|SLMAP_uc003djf.1_Missense_Mutation_p.A554S|SLMAP_uc003djg.1_Missense_Mutation_p.A186S|SLMAP_uc011bez.1_Missense_Mutation_p.A60S|SLMAP_uc011bfa.1_Missense_Mutation_p.A126S|SLMAP_uc003djh.2_Missense_Mutation_p.A85S|SLMAP_uc003dji.1_Missense_Mutation_p.A126S|SLMAP_uc011bfb.1_Missense_Mutation_p.A126S|SLMAP_uc011bfc.1_Missense_Mutation_p.A85S	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	592	Cytoplasmic (Potential).|Potential.				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		TCAAGCAGCAGCAAAGGTTGC	0.483													T	57898233	T	T	57898233	3	4	216	1	0	0	0	0	1	0	0	0	14749	971	34	5	1789	5	SLMAP	3	57898233	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	8174929	57898233	140124197	12	15143											
ARPM1	84517	broad.mit.edu	37	chr3	169487253	169487253	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccggcacccagccacgcccGccttgatcattcccgagccg	9	21	1	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr3:169487253G>A	uc003ffs.1	-	1	431	c.56C>T	c.(55-57)GCG>GTG	p.A19V		NM_032487	NP_115876	Q9BYD9	ARPM1_HUMAN	actin related protein M1	19						cytoplasm|cytoskeleton					0	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;5.01e-59)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			AGCCACGCCCGCCTTGATCAT	0.672													A	169487253	A	A	169487253	3	1	216	1	0	0	0	0	1	0	0	0	976	1087	38	1	1070	1	ARPM1	3	169487253	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	111589020	169487253	28535177	13	15144											
KIAA1109	84162	broad.mit.edu	37	chr4	123238013	123238013	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aggccaaagtaatagatgatCtgaagtatgtacaatgattt	9	4	1	4			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr4:123238013C>G	uc003ieh.2	+	60	10711	c.10666C>G	c.(10666-10668)CTG>GTG	p.L3556V	KIAA1109_uc003iel.1_Missense_Mutation_p.L1491V	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3556					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AATAGATGATCTGAAGTATGT	0.254													G	123238013	G	G	123238013	3	3	216	1	0	0	0	0	1	0	0	0	8208	912	32	5	10904	5	KIAA1109	4	123238013	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08		123238013	67916263	14	15145											
KIAA1712	80817	broad.mit.edu	37	chr4	175229838	175229838	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttacatatttttctctatgcAgaagaaagctgtggtgattc	8	6	1	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr4:175229838A>G	uc003itr.2	+	7	922	c.508_splice	c.e7-2	p.K170_splice	KIAA1712_uc010iro.2_Splice_Site_p.K170_splice|KIAA1712_uc003its.2_Splice_Site	NM_001040157	NP_001035247	Q9C0F1	CEP44_HUMAN	HBV PreS1-transactivated protein 3 isoform a							centrosome|midbody|spindle pole					0		Prostate(90;0.00276)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;4.06e-18)|Epithelial(43;1.18e-15)|OV - Ovarian serous cystadenocarcinoma(60;4.65e-09)|GBM - Glioblastoma multiforme(59;0.00098)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0949)		TTCTCTATGCAGAAGAAAGCT	0.249													G	175229838	G	G	175229838	5	3	216	1	0	0	0	0	0	0	1	0	8253	202	7	4	524	4	KIAA1712	4	175229838	Splice_Site	SNP	A	TCGA-28-5216-01A-01D-1486-08	51991825	175229838	15924438	15	15146											
ZNF608	57507	broad.mit.edu	37	chr5	124080387	124080387	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttttgatttgctggtctctTtgtgtgaattcccctgggga	11	8	1	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr5:124080387T>G	uc003ktq.1	-	1	419	c.296A>C	c.(295-297)AAA>ACA	p.K99T	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Missense_Mutation_p.K99T|ZNF608_uc003ktt.1_Missense_Mutation_p.K99T	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	99						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCTGGTCTCTTTGTGTGAATT	0.507													G	124080387	G	G	124080387	3	3	216	1	0	0	0	0	1	0	0	0	18031	1841	64	5	4278	5	ZNF608	5	124080387	Missense_Mutation	SNP	T	TCGA-28-5216-01A-01D-1486-08		124080387	56834873	16	15147											
PCDHA1	56147	broad.mit.edu	37	chr5	140166327	140166327	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctagactcctgaattcgcGttttccgatagaaggagctg	10	9	1	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr5:140166327G>A	uc003lhb.2	+	1	452	c.452G>A	c.(451-453)CGT>CAT	p.R151H	PCDHA1_uc003lha.2_Missense_Mutation_p.R151H|PCDHA1_uc003lgz.2_Missense_Mutation_p.R151H	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	151	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAATTCGCGTTTTCCGATA	0.448													A	140166327	A	A	140166327	3	1	216	1	0	0	0	0	1	0	0	0	11519	1145	40	1	454	1	PCDHA1	5	140166327	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	16085940	140166327	40748933	17	15148											
MYLIP	29116	broad.mit.edu	37	chr6	16141881	16141881	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tctttttcttgcacatcaagGaggccctcttggcaggccac	9	13	4	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr6:16141881G>C	uc003nbq.2	+	3	541	c.304G>C	c.(304-306)GAG>CAG	p.E102Q	MYLIP_uc003nbr.2_5'UTR	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	102	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GCACATCAAGGAGGCCCTCTT	0.512													C	16141881	C	C	16141881	3	2	216	1	0	0	0	0	1	0	0	0	10055	1175	41	5	314	5	MYLIP	6	16141881	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08		16141881	154973186	18	15149											
C7orf65	401335	broad.mit.edu	37	chr7	47698593	47698593	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gctggggaagcagggagctgCtatttctgttcaaggcaatc	14	8	2	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr7:47698593C>A	uc010kyp.1	+	3	258	c.223C>A	c.(223-225)CTA>ATA	p.L75I		NM_001123065	NP_001116537	Q6ZTY9	CG065_HUMAN	hypothetical protein LOC401335	75											0						CAGGGAGCTGCTATTTCTGTT	0.502													A	47698593	A	A	47698593	3	1	216	1	0	0	0	0	1	0	0	0	2411	796	28	5	233	5	C7orf65	7	47698593	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08		47698593	111440070	19	15150											
MUC17	140453	broad.mit.edu	37	chr7	100701312	100701312	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagaggcctcaggtaatgaCgacatcattttaaggcatgg	11	8	3	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr7:100701312C>T	uc003uxp.1	+	13	13522	c.13469C>T	c.(13468-13470)ACG>ATG	p.T4490M	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4490	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGGTAATGACGACATCATTT	0.493													T	100701312	T	T	100701312	3	4	216	1	0	0	0	0	1	0	0	0	9974	536	19	1	13519	1	MUC17	7	100701312	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08	53002719	100701312	58437351	20	15151											
SLC26A3	1811	broad.mit.edu	37	chr7	107416977	107416977	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tctgaaaattttcactccttCtggctcatacatctgtaagg	6	10	5	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr7:107416977C>G	uc003ver.2	-	15	1808	c.1597G>C	c.(1597-1599)GAA>CAA	p.E533Q	SLC26A3_uc003ves.2_Missense_Mutation_p.E498Q	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	533	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TTCACTCCTTCTGGCTCATAC	0.378													G	107416977	G	G	107416977	3	3	216	1	0	0	0	0	1	0	0	0	14518	922	32	5	725	5	SLC26A3	7	107416977	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08	6715665	107416977	51721686	21	15152											
OR6B1	135946	broad.mit.edu	37	chr7	143701298	143701298	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggccaacctgtccttcttggAgacctggtacatctctgtga	10	12	2	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr7:143701298A>T	uc003wdt.1	+	1	209	c.209A>T	c.(208-210)GAG>GTG	p.E70V		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					TCCTTCTTGGAGACCTGGTAC	0.458													T	143701298	T	T	143701298	3	4	216	1	0	0	0	0	1	0	0	0	11187	304	11	5	211	5	OR6B1	7	143701298	Missense_Mutation	SNP	A	TCGA-28-5216-01A-01D-1486-08	36284321	143701298	15437365	22	15153											
RUNX1T1	862	broad.mit.edu	37	chr8	93027036	93027036	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggctgtaggagaatggctcGtgccattagttactgtcaag	13	7	1	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr8:93027036G>A	uc003yfd.2	-	3	323	c.239C>T	c.(238-240)ACG>ATG	p.T80M	RUNX1T1_uc003yfc.1_Missense_Mutation_p.T53M|RUNX1T1_uc003yfe.1_Missense_Mutation_p.T43M|RUNX1T1_uc010mao.2_Missense_Mutation_p.T53M|RUNX1T1_uc011lgi.1_Missense_Mutation_p.T91M|RUNX1T1_uc003yfh.1_Missense_Mutation_p.T43M|RUNX1T1_uc003yfb.1_Missense_Mutation_p.T43M|RUNX1T1_uc003yff.1_Missense_Mutation_p.T43M|RUNX1T1_uc003yfg.1_Missense_Mutation_p.T43M	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	80					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			AGAATGGCTCGTGCCATTAGT	0.473													A	93027036	A	A	93027036	3	1	216	1	0	0	0	0	1	0	0	0	13747	1145	40	1	1611	1	RUNX1T1	8	93027036	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08		93027036	53336986	23	15154											
KCNK9	51305	broad.mit.edu	37	chr8	140630517	140630517	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acacctaaacggacttccggCgtttcatcagcctctggtgg	10	13	3	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr8:140630517C>T	uc003yvf.1	-	2	1173	c.1109G>A	c.(1108-1110)CGC>CAC	p.R370H	KCNK9_uc003yvg.1_Missense_Mutation_p.R370H|KCNK9_uc003yve.1_RNA	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	370	Cytoplasmic (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			GGACTTCCGGCGTTTCATCAG	0.453													T	140630517	T	T	140630517	3	4	216	1	0	0	0	0	1	0	0	0	8072	768	27	1	19	1	KCNK9	8	140630517	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08	47603481	140630517	5733505	24	15155											
PLEC	5339	broad.mit.edu	37	chr8	144992145	144992145	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcttcatggcctggtacacCgagagccgttccttggtggc	12	12	2	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr8:144992145C>T	uc003zaf.1	-	32	12425	c.12255G>A	c.(12253-12255)TCG>TCA	p.S4085S	PLEC_uc003zab.1_Silent_p.S3948S|PLEC_uc003zac.1_Silent_p.S3952S|PLEC_uc003zad.2_Silent_p.S3948S|PLEC_uc003zae.1_Silent_p.S3916S|PLEC_uc003zag.1_Silent_p.S3926S|PLEC_uc003zah.2_Silent_p.S3934S|PLEC_uc003zaj.2_Silent_p.S3975S	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4085	Plectin 22.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCTGGTACACCGAGAGCCGTT	0.612													T	144992145	T	T	144992145	2	4	216	1	0	0	0	0	0	0	0	1	12052	639	23	2		2	PLEC	8	144992145	Silent	SNP	C	TCGA-28-5216-01A-01D-1486-08	4361628	144992145	1371877	25	15156											
PTEN	5728	broad.mit.edu	37	chr10	89653826	89653826	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgggatttcctgcagaaagaCttgaaggcgtatacaggaac	12	7	0	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr10:89653826C>G	uc001kfb.2	+	3	1155	c.124C>G	c.(124-126)CTT>GTT	p.L42V		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	42	Phosphatase tensin-type.		L -> R (in glioma; retains phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3; retains the ability to bind phospholipid membranes).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.L42R(6)|p.?(4)|p.Y27_N212>Y(2)|p.Y27fs*1(2)|p.L42P(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGCAGAAAGACTTGAAGGCGT	0.294		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			G	89653826	G	G	89653826	3	3	216	1	0	0	0	0	1	0	0	0	12738	565	20	5	130	5	PTEN	10	89653826	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08		89653826	45880921	26	15157											
SLC18A2	6571	broad.mit.edu	37	chr10	119014867	119014867	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtgctggccgccctggtactCttggatggaggtgagtgagt	17	8	1	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr10:119014867C>T	uc001ldd.1	+	7	811	c.780C>T	c.(778-780)CTC>CTT	p.L260L	SLC18A2_uc009xyy.1_Silent_p.L57L	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	260	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	CCCTGGTACTCTTGGATGGAG	0.627													T	119014867	T	T	119014867	2	4	216	1	0	0	0	0	0	0	0	1	14426	900	32	3		3	SLC18A2	10	119014867	Silent	SNP	C	TCGA-28-5216-01A-01D-1486-08	29361041	119014867	16519880	27	15158											
OR51E1	143503	broad.mit.edu	37	chr11	4673967	4673967	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tatttctttgcatgctttcaGgcattgacatcctcatctcc	5	12	4	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr11:4673967G>C	uc001lzi.3	+	2	355	c.211G>C	c.(211-213)GGC>CGC	p.G71R		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CATGCTTTCAGGCATTGACAT	0.453													C	4673967	C	C	4673967	3	2	216	1	0	0	0	0	1	0	0	0	11094	1000	35	5	213	5	OR51E1	11	4673967	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08		4673967	130332549	28	15159											
OR4B1	119765	broad.mit.edu	37	chr11	48238725	48238725	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatggcctatgattgctacGtggccatttgcaagcctctt	10	10	1	2	rs150231573	byFrequency	TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr11:48238725G>A	uc010rhs.1	+	1	364	c.364G>A	c.(364-366)GTG>ATG	p.V122M		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						TGATTGCTACGTGGCCATTTG	0.473													A	48238725	A	A	48238725	3	1	216	1	0	0	0	0	1	0	0	0	11044	1145	40	1	366	1	OR4B1	11	48238725	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	43564758	48238725	86767791	29	15160											
MS4A14	84689	broad.mit.edu	37	chr11	60164081	60164081	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acatcccaggacagaagggcAactcacgtcatcactataaa	7	12	3	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr11:60164081A>T	uc001npj.2	+	1	595	c.30A>T	c.(28-30)GCA>GCT	p.A10A	MS4A14_uc001npi.2_Intron|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Silent_p.A10A|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	10						integral to membrane	receptor activity			breast(1)	1						ACAGAAGGGCAACTCACGTCA	0.458													T	60164081	T	T	60164081	2	4	216	1	0	0	0	0	0	0	0	1	9858	117	5	5		5	MS4A14	11	60164081	Silent	SNP	A	TCGA-28-5216-01A-01D-1486-08	11925356	60164081	74842435	30	15161											
P2RY2	5029	broad.mit.edu	37	chr11	72946285	72946285	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcagtgaggactctaggCggacagagtccacgccggct	15	12	1	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr11:72946285C>T	uc001otj.2	+	3	1414	c.1081C>T	c.(1081-1083)CGG>TGG	p.R361W	P2RY2_uc001otk.2_Missense_Mutation_p.R361W|P2RY2_uc001otl.2_Missense_Mutation_p.R361W	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	361	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.R361P(1)		ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	GGACTCTAGGCGGACAGAGTC	0.582													T	72946285	T	T	72946285	3	4	216	1	0	0	0	0	1	0	0	0	11352	759	27	1	1083	1	P2RY2	11	72946285	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08	12782204	72946285	62060231	31	15162											
GDPD5	81544	broad.mit.edu	37	chr11	75160035	75160035	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactcaccatgggggccccgCggtggccaatgagagcaggc	15	14	1	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr11:75160035C>T	uc001owo.3	-	10	1238	c.701G>A	c.(700-702)CGC>CAC	p.R234H	GDPD5_uc001owp.3_Missense_Mutation_p.R234H|GDPD5_uc001own.3_5'UTR|GDPD5_uc009yuc.2_Missense_Mutation_p.R96H|GDPD5_uc009yud.2_Missense_Mutation_p.R115H|GDPD5_uc009yue.1_Missense_Mutation_p.R122H	NM_030792	NP_110419	Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain	234	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			ovary(1)	1						GGGGGCCCCGCGGTGGCCAAT	0.607													T	75160035	T	T	75160035	3	4	216	1	0	0	0	0	1	0	0	0	6327	768	27	1	1152	1	GDPD5	11	75160035	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08	2213750	75160035	59846481	32	15163											
USP35	57558	broad.mit.edu	37	chr11	77920718	77920718	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttccctcctcctgagcgctGtcgccgccgccgcctgggct	11	20	0	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr11:77920718G>A	uc009yva.1	+	10	2063	c.1817G>A	c.(1816-1818)TGT>TAT	p.C606Y	USP35_uc001oze.2_Missense_Mutation_p.C362Y|USP35_uc001ozc.2_Missense_Mutation_p.C174Y|USP35_uc010rsp.1_Missense_Mutation_p.C38Y|USP35_uc001ozd.2_Missense_Mutation_p.C217Y|USP35_uc001ozf.2_Missense_Mutation_p.C337Y	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	606					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CCTGAGCGCTGTCGCCGCCGC	0.657													A	77920718	A	A	77920718	3	1	216	1	0	0	0	0	1	0	0	0	17063	1377	48	3	1851	3	USP35	11	77920718	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	2760683	77920718	57085798	33	15164											
HEPHL1	341208	broad.mit.edu	37	chr11	93803618	93803618	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgaagggtcaacagaggcGctactttatagcagctgaaa	12	7	1	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr11:93803618G>A	uc001pep.2	+	6	1299	c.1142G>A	c.(1141-1143)CGC>CAC	p.R381H	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	381	Plastocyanin-like 3.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CAACAGAGGCGCTACTTTATA	0.443													A	93803618	A	A	93803618	3	1	216	1	0	0	0	0	1	0	0	0	7055	1087	38	1	1164	1	HEPHL1	11	93803618	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	15882900	93803618	41202898	34	15165											
FUT4	2526	broad.mit.edu	37	chr11	94278241	94278244	+	Frame_Shift_Del	DEL	CAAC	-	-													agcctggcaagtaacctcttCaactggacgctctcctaccg							TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr11:94278241_94278244delCAAC	uc001pez.2	+	1	1225_1228	c.942_945delCAAC	c.(940-945)TTCAACfs	p.F314fs	PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.1_5'Flank	NM_002033	NP_002024	P22083	FUT4_HUMAN	fucosyltransferase 4	314_315	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			skin(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GTAACCTCTTCAACTGGACGCTCT	0.681													-	94278244	-	-	94278241	7	5	216	1	0	1	0	1	0	0	0	0	6106	825	29	0	944	0	FUT4	11	94278241	Frame_Shift_Del	DEL	CAAC	TCGA-28-5216-01A-01D-1486-08	474623	94278241	40728275	35	15166											
SOX5	6660	broad.mit.edu	37	chr12	24048786	24048786	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtctcttgcgtcagcagagAaactggctgaaattcctcag	10	10	3	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr12:24048786A>G	uc001rfw.2	-	2	313	c.211T>C	c.(211-213)TCT>CCT	p.S71P	SOX5_uc001rfx.2_Missense_Mutation_p.S58P|SOX5_uc001rfy.2_Missense_Mutation_p.S58P|SOX5_uc010siv.1_Missense_Mutation_p.S58P|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Intron|SOX5_uc001rga.2_Intron	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	71					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GTCAGCAGAGAAACTGGCTGA	0.483													G	24048786	G	G	24048786	3	3	216	1	0	0	0	0	1	0	0	0	14954	246	9	4	2146	4	SOX5	12	24048786	Missense_Mutation	SNP	A	TCGA-28-5216-01A-01D-1486-08		24048786	109803109	36	15167											
OR8S1	341568	broad.mit.edu	37	chr12	48919470	48919470	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcctccttgggctgtctgCcgaccccaacatccgggctc	9	19	1	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr12:48919470C>T	uc010slu.1	+	1	56	c.56C>T	c.(55-57)GCC>GTC	p.A19V		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGGCTGTCTGCCGACCCCAAC	0.512													T	48919470	T	T	48919470	3	4	216	1	0	0	0	0	1	0	0	0	11246	739	26	3	58	3	OR8S1	12	48919470	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08	24870684	48919470	84932425	37	15168											
ADCY6	112	broad.mit.edu	37	chr12	49177053	49177053	+	Silent	SNP	G	T	T													cgaggggggcccgcaggggtGgggctgggtggctctgcatc							TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr12:49177053G>T	uc001rsh.3	-	1	825	c.165C>A	c.(163-165)CCC>CCA	p.P55P	ADCY6_uc001rsj.3_Silent_p.P55P|ADCY6_uc001rsi.3_Silent_p.P55P	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	55	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CCGCAGGGGTGGGGCTGGGTG	0.726													T	49177053	T	T	49177053	2	4	216	1	0	0	0	0	0	0	0	1	298	1335	47	5		5	ADCY6	12	49177053	Silent	SNP	G	TCGA-28-5216-01A-01D-1486-08	257583	49177053	84674842	38	15169	18	2									
ADCY6	112	broad.mit.edu	37	chr12	49177063	49177063	+	Missense_Mutation	SNP	G	A	A													ccgcaggggtggggctgggtGgctctgcatcccggaggcag							TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr12:49177063G>A	uc001rsh.3	-	1	815	c.155C>T	c.(154-156)CCA>CTA	p.P52L	ADCY6_uc001rsj.3_Missense_Mutation_p.P52L|ADCY6_uc001rsi.3_Missense_Mutation_p.P52L	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	52	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						GGGGCTGGGTGGCTCTGCATC	0.716													A	49177063	A	A	49177063	3	1	216	1	0	0	0	0	1	0	0	0	298	1348	47	3	3435	3	ADCY6	12	49177063	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	10	49177063	84674832	39	15170	18	2									
CEP290	80184	broad.mit.edu	37	chr12	88505570	88505570	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcatttcttccggtaagctgAtcaacttgggctttcaaatg	8	9	4	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr12:88505570A>G	uc001tar.2	-	21	2462	c.2118T>C	c.(2116-2118)GAT>GAC	p.D706D	CEP290_uc001tat.2_Silent_p.D499D|CEP290_uc009zsl.1_RNA	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	706	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						CGGTAAGCTGATCAACTTGGG	0.368													G	88505570	G	G	88505570	2	3	216	1	0	0	0	0	0	0	0	1	3253	330	12	4		4	CEP290	12	88505570	Silent	SNP	A	TCGA-28-5216-01A-01D-1486-08	39328507	88505570	45346325	40	15171											
ARL1	400	broad.mit.edu	37	chr12	101796696	101796696	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaatttaaggtttttgtaCgtcaccgtctctacattaaa	7	7	2	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr12:101796696C>T	uc001tib.2	-	3	320	c.171G>A	c.(169-171)ACG>ACA	p.T57T	ARL1_uc010svn.1_Silent_p.T11T|ARL1_uc010svo.1_RNA|ARL1_uc001tic.2_Silent_p.T57T	NM_001177	NP_001168	P40616	ARL1_HUMAN	ADP-ribosylation factor-like 1	57					small GTPase mediated signal transduction	Golgi membrane	enzyme activator activity|GTP binding|GTPase activity|metal ion binding|protein binding			central_nervous_system(1)	1		Lung NSC(355;2.1e-05)|Breast(359;0.00015)|Myeloproliferative disorder(1001;0.163)		GBM - Glioblastoma multiforme(134;1.67e-09)|BRCA - Breast invasive adenocarcinoma(302;0.0125)		GGTTTTTGTACGTCACCGTCT	0.358													T	101796696	T	T	101796696	2	4	216	1	0	0	0	0	0	0	0	1	925	523	19	1		1	ARL1	12	101796696	Silent	SNP	C	TCGA-28-5216-01A-01D-1486-08	13291126	101796696	32055199	41	15172											
SACS	26278	broad.mit.edu	37	chr13	23911703	23911703	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatggcaaaaccaaaggatgCccctccaaggaacaaggaat	10	10	0	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr13:23911703C>T	uc001uon.2	-	10	6901	c.6312G>A	c.(6310-6312)GGG>GGA	p.G2104G	SACS_uc001uoo.2_Silent_p.G1957G|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2104					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CCAAAGGATGCCCCTCCAAGG	0.403													T	23911703	T	T	23911703	2	4	216	1	0	0	0	0	0	0	0	1	13804	726	26	3		3	SACS	13	23911703	Silent	SNP	C	TCGA-28-5216-01A-01D-1486-08		23911703	91258175	42	15173											
HEATR5A	25938	broad.mit.edu	37	chr14	31816973	31816973	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgcacatcaggagaagtgCtgtcctgcgccaaagtataa	10	11	1	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr14:31816973C>T	uc001wrf.3	-	13	2047	c.1970G>A	c.(1969-1971)AGC>AAC	p.S657N	HEATR5A_uc010ami.2_Missense_Mutation_p.S555N|HEATR5A_uc001wrg.1_Missense_Mutation_p.S539N|HEATR5A_uc010tpk.1_Missense_Mutation_p.S950N	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	944							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		AGGAGAAGTGCTGTCCTGCGC	0.383													T	31816973	T	T	31816973	3	4	216	1	0	0	0	0	1	0	0	0	7031	797	28	3	3363	3	HEATR5A	14	31816973	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08		31816973	75532567	43	15174											
GPR132	29933	broad.mit.edu	37	chr14	105518249	105518249	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaggtagacggccagcacGttgccctgcagtacctgcag	13	13	0	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr14:105518249G>A	uc001yqd.2	-	4	1124	c.225C>T	c.(223-225)AAC>AAT	p.N75N	GPR132_uc001yqc.2_Translation_Start_Site|GPR132_uc001yqe.2_Silent_p.N66N	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	75	Cytoplasmic (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		CGGCCAGCACGTTGCCCTGCA	0.647													A	105518249	A	A	105518249	2	1	216	1	0	0	0	0	0	0	0	1	6642	1136	40	1		1	GPR132	14	105518249	Silent	SNP	G	TCGA-28-5216-01A-01D-1486-08	73701276	105518249	1831291	44	15175											
C15orf55	256646	broad.mit.edu	37	chr15	34640826	34640826	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgttacaaagccttggccCggaggcacctatcccagagt	11	13	0	1	rs138533937		TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr15:34640826C>T	uc001zif.2	+	2	828	c.673C>T	c.(673-675)CGG>TGG	p.R225W	C15orf55_uc010ucc.1_Missense_Mutation_p.R253W|C15orf55_uc010ucd.1_Missense_Mutation_p.R243W	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	225						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AGCCTTGGCCCGGAGGCACCT	0.483			T	BRD3|BRD4	lethal midline carcinoma								T	34640826	T	T	34640826	3	4	216	1	0	0	0	0	1	0	0	0	1803	643	23	2	679	2	C15orf55	15	34640826	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08		34640826	67890566	45	15176											
TRPM7	54822	broad.mit.edu	37	chr15	50935595	50935595	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtaactgcagctttaataagAccttttccaagcaactgctt	6	10	0	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr15:50935595A>G	uc001zyt.3	-	5	741	c.477T>C	c.(475-477)GGT>GGC	p.G159G	TRPM7_uc010bew.1_Silent_p.G159G	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	159	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		CTTTAATAAGACCTTTTCCAA	0.383													G	50935595	G	G	50935595	2	3	216	1	0	0	0	0	0	0	0	1	16588	262	10	4		4	TRPM7	15	50935595	Silent	SNP	A	TCGA-28-5216-01A-01D-1486-08	16294769	50935595	51595797	46	15177											
KIF7	374654	broad.mit.edu	37	chr15	90189143	90189143	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgcgcaggtgtaaggtccGcctgggcggctcctcctcct	13	16	0	0	rs150543610		TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr15:90189143G>A	uc002bof.2	-	8	1980	c.1903C>T	c.(1903-1905)CGG>TGG	p.R635W	KIF7_uc010upw.1_Missense_Mutation_p.R122W	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	635					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TGTAAGGTCCGCCTGGGCGGc	0.577													A	90189143	A	A	90189143	3	1	216	1	0	0	0	0	1	0	0	0	8309	1086	38	1	2176	1	KIF7	15	90189143	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	39253548	90189143	12342249	47	15178											
UMOD	7369	broad.mit.edu	37	chr16	20357616	20357616	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cccagcgacaccttcatgtcAttggccccacattccagcct	6	18	2	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr16:20357616A>T	uc002dgz.2	-	5	1143	c.1014T>A	c.(1012-1014)AAT>AAA	p.N338K	UMOD_uc002dha.2_Missense_Mutation_p.N338K|UMOD_uc002dhb.2_Missense_Mutation_p.N371K	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	338	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						CCTTCATGTCATTGGCCCCAC	0.557													T	20357616	T	T	20357616	3	4	216	1	0	0	0	0	1	0	0	0	16976	214	8	5	936	5	UMOD	16	20357616	Missense_Mutation	SNP	A	TCGA-28-5216-01A-01D-1486-08		20357616	69997137	48	15179											
TP53	7157	broad.mit.edu	37	chr17	7577535	7577535	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgatgatggtgaggatgggcCtccggttcatgccgcccatg	15	10	1	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr17:7577535C>A	uc002gim.2	-	7	940	c.746G>T	c.(745-747)AGG>ATG	p.R249M	TP53_uc002gig.1_Missense_Mutation_p.R249M|TP53_uc002gih.2_Missense_Mutation_p.R249M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R117M|TP53_uc010cng.1_Missense_Mutation_p.R117M|TP53_uc002gii.1_Missense_Mutation_p.R117M|TP53_uc010cnh.1_Missense_Mutation_p.R249M|TP53_uc010cni.1_Missense_Mutation_p.R249M|TP53_uc002gij.2_Missense_Mutation_p.R249M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R156M|TP53_uc002gio.2_Missense_Mutation_p.R117M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	249	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> I (in a sporadic cancer; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249S(303)|p.R249M(25)|p.R249G(24)|p.R249W(23)|p.R249T(16)|p.R249K(14)|p.0?(7)|p.R249R(6)|p.R249fs*96(6)|p.M246_P250delMNRRP(2)|p.R249fs*14(2)|p.R248_P250delRRP(1)|p.R249_P250delRP(1)|p.R249_P250insR(1)|p.R249_P250>SS(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*19(1)|p.R249_T256delRPILTIIT(1)|p.R249fs*15(1)|p.R249_I251delRPI(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGATGGGCCTCCGGTTCAT	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577535	A	A	7577535	3	1	216	1	0	0	0	0	1	0	0	0	16378	681	24	5	544	5	TP53	17	7577535	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08		7577535	73617675	49	15180											
CHD3	1107	broad.mit.edu	37	chr17	7811263	7811263	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggcctcgagatgagccacGgtccaatgggcgacgagagg	17	10	0	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr17:7811263G>A	uc002gje.2	+	34	5228	c.5078G>A	c.(5077-5079)CGG>CAG	p.R1693Q	CHD3_uc002gjd.2_Missense_Mutation_p.R1752Q|CHD3_uc002gjf.2_Missense_Mutation_p.R1659Q|CHD3_uc002gjh.2_Missense_Mutation_p.R270Q|CHD3_uc002gjj.2_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1693	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GATGAGCCACGGTCCAATGGG	0.567													A	7811263	A	A	7811263	3	1	216	1	0	0	0	0	1	0	0	0	3326	1116	39	2	5493	2	CHD3	17	7811263	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08	233728	7811263	73383947	50	15181											
MYH2	4620	broad.mit.edu	37	chr17	10428377	10428377	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttccctcttcatgttcaagAgatgccttaatgacagcaag	7	10	3	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr17:10428377A>G	uc010coi.2	-	34	4796	c.4668T>C	c.(4666-4668)TCT>TCC	p.S1556S	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.S1556S|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1556	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CATGTTCAAGAGATGCCTTAA	0.388													G	10428377	G	G	10428377	2	3	216	1	0	0	0	0	0	0	0	1	10035	291	11	4		4	MYH2	17	10428377	Silent	SNP	A	TCGA-28-5216-01A-01D-1486-08	2617114	10428377	70766833	51	15182											
ABCA8	10351	broad.mit.edu	37	chr17	66924136	66924136	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aacatgaaatttgttgctacAatgagatttgagccgtccga	9	7	0	3			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr17:66924136A>T	uc002jhp.2	-	9	1373	c.1194T>A	c.(1192-1194)ATT>ATA	p.I398I	ABCA8_uc002jhq.2_Silent_p.I398I|ABCA8_uc010wqq.1_Silent_p.I398I|ABCA8_uc010wqr.1_Silent_p.I337I|ABCA8_uc002jhr.2_Silent_p.I398I	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	398	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TTGTTGCTACAATGAGATTTG	0.328													T	66924136	T	T	66924136	2	4	216	1	0	0	0	0	0	0	0	1	38	126	5	5		5	ABCA8	17	66924136	Silent	SNP	A	TCGA-28-5216-01A-01D-1486-08	56495759	66924136	14271074	52	15183											
DSG3	1830	broad.mit.edu	37	chr18	29052349	29052349	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggctcagaaggaacaattcAtcagtggggaattgaaggag	14	5	3	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr18:29052349A>G	uc002kws.2	+	13	2109	c.2000A>G	c.(1999-2001)CAT>CGT	p.H667R	DSG3_uc002kwt.2_5'Flank	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	667	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGAACAATTCATCAGTGGGGA	0.448													G	29052349	G	G	29052349	3	3	216	1	0	0	0	0	1	0	0	0	4778	217	8	4	2050	4	DSG3	18	29052349	Missense_Mutation	SNP	A	TCGA-28-5216-01A-01D-1486-08		29052349	49024899	53	15184											
ZFR2	23217	broad.mit.edu	37	chr19	3823274	3823274	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tattccgggcccaccggctgCgcatcagagcagcccgcggg	14	16	1	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr19:3823274C>A	uc002lyw.2	-	8	1353	c.1341G>T	c.(1339-1341)GCG>GCT	p.A447A	ZFR2_uc010xhx.1_RNA	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	447						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CCACCGGCTGCGCATCAGAGC	0.622													A	3823274	A	A	3823274	2	1	216	1	0	0	0	0	0	0	0	1	17657	755	27	5		5	ZFR2	19	3823274	Silent	SNP	C	TCGA-28-5216-01A-01D-1486-08		3823274	55305709	54	15185											
RFX1	5989	broad.mit.edu	37	chr19	14079442	14079442	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccccgtgctcggctgctgcCccaccgccacgccgttggtc	12	20	0	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr19:14079442C>T	uc002mxv.2	-	12	1939	c.1667G>A	c.(1666-1668)GGG>GAG	p.G556E		NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	556					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CGGCTGCTGCCCCACCGCCAC	0.662													T	14079442	T	T	14079442	3	4	216	1	0	0	0	0	1	0	0	0	13262	623	22	3	1312	3	RFX1	19	14079442	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08	10256168	14079442	45049541	55	15186											
CPAMD8	27151	broad.mit.edu	37	chr19	17013524	17013524	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcggccgctgggtcatcatcGtcagctgggggccagtctcc	14	14	4	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr19:17013524G>A	uc002nfb.2	-	35	4793	c.4761C>T	c.(4759-4761)GAC>GAT	p.D1587D	CPAMD8_uc002nfd.1_Silent_p.D52D	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1540	Poly-Asp.					extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGTCATCATCGTCAGCTGGGG	0.662													A	17013524	A	A	17013524	2	1	216	1	0	0	0	0	0	0	0	1	3795	1136	40	1		1	CPAMD8	19	17013524	Silent	SNP	G	TCGA-28-5216-01A-01D-1486-08	2934082	17013524	42115459	56	15187											
CEACAM20	125931	broad.mit.edu	37	chr19	45021085	45021085	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtgcagttgtagatcccgtCgtgttcccaggtcagagccc	12	12	1	2			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr19:45021085C>T	uc010ejn.1	-	6	1247	c.1231G>A	c.(1231-1233)GAC>AAC	p.D411N	CEACAM20_uc010ejo.1_Missense_Mutation_p.D411N|CEACAM20_uc010ejp.1_Intron|CEACAM20_uc010ejq.1_Intron	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	411	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				TAGATCCCGTCGTGTTCCCAG	0.592													T	45021085	T	T	45021085	3	4	216	1	0	0	0	0	1	0	0	0	3191	884	31	2	588	2	CEACAM20	19	45021085	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08	28007561	45021085	14107898	57	15188											
VN1R2	317701	broad.mit.edu	37	chr19	53761868	53761868	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactctcttgtctctgcacaCggagagaaacccaccaaacc	6	16	2	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr19:53761868C>T	uc002qbi.2	+	1	324	c.240C>T	c.(238-240)CAC>CAT	p.H80H		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	80	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		tctctgcacacggagagaaac	0.104													T	53761868	T	T	53761868	2	4	216	1	0	0	0	0	0	0	0	1	17176	535	19	1		1	VN1R2	19	53761868	Silent	SNP	C	TCGA-28-5216-01A-01D-1486-08	8740783	53761868	5367115	58	15189											
MMP9	4318	broad.mit.edu	37	chr20	44639814	44639814	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtttggaaacgcagatggcGcggcctgccacttccccttc	12	14	0	1			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr20:44639814G>A	uc002xqz.2	+	5	701	c.682G>A	c.(682-684)GCG>ACG	p.A228T		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	228	Fibronectin type-II 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding	p.A228A(1)		ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CGCAGATGGCGCGGCCTGCCA	0.637													A	44639814	A	A	44639814	3	1	216	1	0	0	0	0	1	0	0	0	9669	1087	38	1	700	1	MMP9	20	44639814	Missense_Mutation	SNP	G	TCGA-28-5216-01A-01D-1486-08		44639814	18385706	59	15190											
SALL4	57167	broad.mit.edu	37	chr20	50408434	50408434	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gcagggagtgcatccgcgctCcgctgattcaccgccacctt	11	16	1	1	rs143754390		TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chr20:50408434C>A	uc002xwh.3	-	2	689	c.588G>T	c.(586-588)CGG>CGT	p.R196R	SALL4_uc010gii.2_Silent_p.R196R|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	196					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CATCCGCGCTCCGCTGATTCA	0.602													A	50408434	A	A	50408434	2	1	216	1	0	0	0	0	0	0	0	1	13813	842	30	5		5	SALL4	20	50408434	Silent	SNP	C	TCGA-28-5216-01A-01D-1486-08	5768620	50408434	12617086	60	15191											
CXorf65	158830	broad.mit.edu	37	chrX	70325861	70325861	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcctctacctggtggcccaCgttccaccttacaaacgtag	8	15	1	0			TCGA-28-5216-01A-01D-1486-08	TCGA-28-5216-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	cde8518a-ce8e-4b54-ab21-5ad4171ab1b3	bae34d9f-b8be-488d-8c8f-bcc0119d1325	g.chrX:70325861C>T	uc011mpo.1	-	3	253	c.239G>A	c.(238-240)CGT>CAT	p.R80H	CXorf65_uc011mpp.1_Missense_Mutation_p.R32H	NM_001025265	NP_001020436	A6NEN9	CX065_HUMAN	hypothetical protein LOC158830	80										central_nervous_system(1)	1						TGGTGGCCCACGTTCCACCTT	0.433													T	70325861	T	T	70325861	3	4	216	1	0	0	0	0	1	0	0	0	4117	536	19	1	328	1	CXorf65	23	70325861	Missense_Mutation	SNP	C	TCGA-28-5216-01A-01D-1486-08		70325861	84944699	61	15192											
ZBTB40	9923	broad.mit.edu	37	chr1	22835047	22835047	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tggagaagcttgtgaaacgtGactctggttcaggtggtttc	14	6	2	3			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr1:22835047G>T	uc001bft.2	+	9	2033	c.1522G>T	c.(1522-1524)GAC>TAC	p.D508Y	ZBTB40_uc001bfu.2_Missense_Mutation_p.D508Y|ZBTB40_uc009vqi.1_Missense_Mutation_p.D396Y|ZBTB40_uc001bfv.1_Missense_Mutation_p.D137Y	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	508					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		TGTGAAACGTGACTCTGGTTC	0.483													T	22835047	T	T	22835047	3	4	217	1	0	0	0	0	1	0	0	0	17539	1290	45	5	1548	5	ZBTB40	1	22835047	Missense_Mutation	SNP	G	TCGA-28-5218-01A-01D-1486-08		22835047	226415574	1	15193											
HMCN1	83872	broad.mit.edu	37	chr1	186121993	186121993	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcttcagtcacctgctgaagTcactgtaaaggtaaaatgcc	9	10	3	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr1:186121993T>G	uc001grq.1	+	96	15237	c.15008T>G	c.(15007-15009)GTC>GGC	p.V5003G	HMCN1_uc001grs.1_Missense_Mutation_p.V572G	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5003	Nidogen G2 beta-barrel.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CCTGCTGAAGTCACTGTAAAG	0.438													G	186121993	G	G	186121993	3	3	217	1	0	0	0	0	1	0	0	0	7220	1667	58	5	15390	5	HMCN1	1	186121993	Missense_Mutation	SNP	T	TCGA-28-5218-01A-01D-1486-08	163286946	186121993	63128628	2	15194											
OBSCN	84033	broad.mit.edu	37	chr1	228559651	228559651	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagcagttgccccatgccctCctggctccttccctccagga	8	19	0	0			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr1:228559651C>T	uc009xez.1	+	94	21216	c.21172C>T	c.(21172-21174)CCT>TCT	p.P7058S	OBSCN_uc001hsr.1_Missense_Mutation_p.P1687S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	7058	Pro-rich.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCCATGCCCTCCTGGCTCCTT	0.672													T	228559651	T	T	228559651	3	4	217	1	0	0	0	0	1	0	0	0	10812	855	30	3	22752	3	OBSCN	1	228559651	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08	42437658	228559651	20690970	3	15195											
KIAA1804	84451	broad.mit.edu	37	chr1	233518426	233518426	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caaaaccagccggccatctaTatatgaactggagaaagaat	8	9	1	3			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr1:233518426T>C	uc001hvt.3	+	10	3341	c.3080T>C	c.(3079-3081)ATA>ACA	p.I1027T	KIAA1804_uc001hvu.3_Missense_Mutation_p.I473T	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	1027					activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				CGGCCATCTATATATGAACTG	0.428													C	233518426	C	C	233518426	3	2	217	1	0	0	0	0	1	0	0	0	8259	1406	49	4	3118	4	KIAA1804	1	233518426	Missense_Mutation	SNP	T	TCGA-28-5218-01A-01D-1486-08	4958775	233518426	15732195	4	15196											
FIGN	55137	broad.mit.edu	37	chr2	164467616	164467616	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gacggatagctgtaactggaGaggttagaagtcccattgta	13	6	0	2			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr2:164467616G>A	uc002uck.1	-	3	1037	c.726C>T	c.(724-726)CTC>CTT	p.L242L		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	242	Pro-rich.					nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						TGTAACTGGAGAGGTTAGAAG	0.612													A	164467616	A	A	164467616	2	1	217	1	0	0	0	0	0	0	0	1	5891	929	33	3		3	FIGN	2	164467616	Silent	SNP	G	TCGA-28-5218-01A-01D-1486-08		164467616	78731757	5	15197											
SENP5	205564	broad.mit.edu	37	chr3	196613120	196613120	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcagtgccacaaacgcctgGgaccagtcatcctgttcttc	10	14	2	0			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr3:196613120G>A	uc003fwz.3	+	2	1317	c.1068G>A	c.(1066-1068)TGG>TGA	p.W356*	SENP5_uc011bty.1_Nonsense_Mutation_p.W356*	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	356					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		CAAACGCCTGGGACCAGTCAT	0.468													A	196613120	A	A	196613120	4	1	217	1	0	0	0	0	0	1	0	0	14049	1241	43	3	1070	3	SENP5	3	196613120	Nonsense_Mutation	SNP	G	TCGA-28-5218-01A-01D-1486-08		196613120	1409310	6	15198											
OR2J2	26707	broad.mit.edu	37	chr6	29142195	29142195	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ccagtcatgtgcatgtatctCcagccaccatcagaaaattc	6	13	3	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr6:29142195C>G	uc011dlm.1	+	1	885	c.783C>G	c.(781-783)CTC>CTG	p.L261L		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCATGTATCTCCAGCCACCAT	0.433													G	29142195	G	G	29142195	2	3	217	1	0	0	0	0	0	0	0	1	11003	842	30	5		5	OR2J2	6	29142195	Silent	SNP	C	TCGA-28-5218-01A-01D-1486-08		29142195	141972872	7	15199											
MUC17	140453	broad.mit.edu	37	chr7	100677921	100677921	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccagcacacctgtgaccaCttattctcaagccagttcat	5	15	2	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr7:100677921C>T	uc003uxp.1	+	3	3277	c.3224C>T	c.(3223-3225)ACT>ATT	p.T1075I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1075	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|16.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTGACCACTTATTCTCAA	0.488													T	100677921	T	T	100677921	3	4	217	1	0	0	0	0	1	0	0	0	9974	565	20	3	3234	3	MUC17	7	100677921	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08		100677921	58460742	8	15200											
EPHA1	2041	broad.mit.edu	37	chr7	143098437	143098437	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctggaacaagggccgtcGgagctgaatgcccacatcct	11	13	1	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr7:143098437G>A	uc003wcz.2	-	3	499	c.412C>T	c.(412-414)CGA>TGA	p.R138*		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	138	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				AAGGGCCGTCGGAGCTGAATG	0.592													A	143098437	A	A	143098437	4	1	217	1	0	0	0	0	0	1	0	0	5165	1124	39	2	2582	2	EPHA1	7	143098437	Nonsense_Mutation	SNP	G	TCGA-28-5218-01A-01D-1486-08	42420516	143098437	16040226	9	15201											
ATP6V1C1	528	broad.mit.edu	37	chr8	104075258	104075258	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcagttgatgacttcagacaCaaagccagagaaaacaagta	9	8	1	4			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr8:104075258C>G	uc003ykz.3	+	9	962	c.717C>G	c.(715-717)CAC>CAG	p.H239Q	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.H164Q|ATP6V1C1_uc003yla.2_Missense_Mutation_p.H239Q|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.H164Q	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	239					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			ACTTCAGACACAAAGCCAGAG	0.328													G	104075258	G	G	104075258	3	3	217	1	0	0	0	0	1	0	0	0	1180	477	17	5	747	5	ATP6V1C1	8	104075258	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08		104075258	42288764	10	15202											
LRRC6	23639	broad.mit.edu	37	chr8	133645122	133645122	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttaagacagtgatctttttCctgctctctgatttgtggtt	8	7	2	3			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr8:133645122C>T	uc003ytk.2	-	5	591	c.517G>A	c.(517-519)GAA>AAA	p.E173K	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	173						cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGATCTTTTTCCTGCTCTCTG	0.398													T	133645122	T	T	133645122	3	4	217	1	0	0	0	0	1	0	0	0	9016	864	30	3	915	3	LRRC6	8	133645122	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08	29569864	133645122	12718900	11	15203											
CDKN2B	1030	broad.mit.edu	37	chr9	22006044	22006044	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgcggtggccccgctcctcgGccaagtccacgggcagacga	14	17	0	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr9:22006044G>T	uc003zpo.2	-	2	719	c.359C>A	c.(358-360)GCC>GAC	p.A120D	MTAP_uc003zpi.1_Intron|CDKN2BAS_uc010miw.1_Intron|CDKN2BAS_uc010mix.1_Intron|CDKN2BAS_uc003zpm.2_Intron|CDKN2B_uc003zpn.2_3'UTR	NM_004936	NP_004927	P42772	CDN2B_HUMAN	cyclin-dependent kinase inhibitor 2B isoform 1	120	ANK 4.				cell cycle arrest|cellular response to nutrient|G1 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|megakaryocyte differentiation|mitotic cell cycle G1/S transition checkpoint|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;1.31e-280)|Lung NSC(2;2.28e-131)|all_lung(2;2.11e-123)|Glioma(2;5.66e-57)|all_neural(2;3.05e-50)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;8.01e-33)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00369)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;3.29e-71)|Epithelial(2;9.08e-60)|LUSC - Lung squamous cell carcinoma(2;5.8e-46)|LUAD - Lung adenocarcinoma(2;1.43e-25)|BRCA - Breast invasive adenocarcinoma(2;5.37e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;6.92e-07)|KIRC - Kidney renal clear cell carcinoma(2;8.63e-07)|OV - Ovarian serous cystadenocarcinoma(39;0.014)|COAD - Colon adenocarcinoma(8;0.143)		CCGCTCCTCGGCCAAGTCCAC	0.701									Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System				T	22006044	T	T	22006044	3	4	217	1	0	0	0	0	1	0	0	0	3164	1203	42	5	61	5	CDKN2B	9	22006044	Missense_Mutation	SNP	G	TCGA-28-5218-01A-01D-1486-08		22006044	119207387	12	15204			1	40		2	2	25	N	G_C	2.6359e-05
CDKN2B	1030	broad.mit.edu	37	chr9	22006068	22006068	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agtccacgggcagacgacccCaggcatcgcgcacgtccagc	12	17	0	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr9:22006068C>A	uc003zpo.2	-	2	695	c.335G>T	c.(334-336)TGG>TTG	p.W112L	MTAP_uc003zpi.1_Intron|CDKN2BAS_uc010miw.1_Intron|CDKN2BAS_uc010mix.1_Intron|CDKN2BAS_uc003zpm.2_Intron|CDKN2B_uc003zpn.2_3'UTR	NM_004936	NP_004927	P42772	CDN2B_HUMAN	cyclin-dependent kinase inhibitor 2B isoform 1	112	ANK 4.				cell cycle arrest|cellular response to nutrient|G1 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|megakaryocyte differentiation|mitotic cell cycle G1/S transition checkpoint|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;1.31e-280)|Lung NSC(2;2.28e-131)|all_lung(2;2.11e-123)|Glioma(2;5.66e-57)|all_neural(2;3.05e-50)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;8.01e-33)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00369)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;3.29e-71)|Epithelial(2;9.08e-60)|LUSC - Lung squamous cell carcinoma(2;5.8e-46)|LUAD - Lung adenocarcinoma(2;1.43e-25)|BRCA - Breast invasive adenocarcinoma(2;5.37e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;6.92e-07)|KIRC - Kidney renal clear cell carcinoma(2;8.63e-07)|OV - Ovarian serous cystadenocarcinoma(39;0.014)|COAD - Colon adenocarcinoma(8;0.143)		CAGACGACCCCAGGCATCGCG	0.726									Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System				A	22006068	A	A	22006068	3	1	217	1	0	0	0	0	1	0	0	0	3164	595	21	5	85	5	CDKN2B	9	22006068	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08	24	22006068	119207363	13	15205			1	40		2	2	25	N	G_C	2.6359e-05
PTPRE	5791	broad.mit.edu	37	chr10	129861345	129861345	+	Splice_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgaaattgtcctctacacacAggtcccaaacaggaaacggt	8	12	1	0			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr10:129861345A>T	uc001lkb.2	+	10	905	c.626_splice	c.e10-2	p.G209_splice	PTPRE_uc009yat.2_Splice_Site_p.G220_splice|PTPRE_uc010qup.1_Splice_Site|PTPRE_uc009yau.2_Splice_Site_p.G209_splice|PTPRE_uc001lkd.2_Splice_Site_p.G151_splice|PTPRE_uc010quq.1_Splice_Site_p.G110_splice	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E						negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CTCTACACACAGGTCCCAAAC	0.522													T	129861345	T	T	129861345	5	4	217	1	0	0	0	0	0	0	1	0	12800	202	7	5	693	5	PTPRE	10	129861345	Splice_Site	SNP	A	TCGA-28-5218-01A-01D-1486-08		129861345	5673402	14	15206											
MEN1	4221	broad.mit.edu	37	chr11	64575521	64575521	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcccggagacccagggcctGgcaggccccaaccacagcaa	11	17	0	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr11:64575521G>A	uc001obj.2	-	3	584	c.511C>T	c.(511-513)CAG>TAG	p.Q171*	MEN1_uc001obk.2_Nonsense_Mutation_p.Q171*|MEN1_uc001obl.2_Nonsense_Mutation_p.Q166*|MEN1_uc001obm.2_Nonsense_Mutation_p.Q166*|MEN1_uc001obn.2_Nonsense_Mutation_p.Q171*|MEN1_uc001obo.2_Nonsense_Mutation_p.Q171*|MEN1_uc001obp.2_Nonsense_Mutation_p.Q166*|MEN1_uc001obq.2_Nonsense_Mutation_p.Q171*|MEN1_uc001obr.2_Nonsense_Mutation_p.Q171*	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	171			Missing (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.R171Q(1)		parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						CCCAGGGCCTGGCAGGCCCCA	0.602			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				A	64575521	A	A	64575521	4	1	217	1	0	0	0	0	0	1	0	0	9472	1357	47	3	1368	3	MEN1	11	64575521	Nonsense_Mutation	SNP	G	TCGA-28-5218-01A-01D-1486-08		64575521	70430995	15	15207											
KRTAP5-11	440051	broad.mit.edu	37	chr11	71293418	71293418	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctgggtccagagcctcagaTcttacactggcagcacacgg	11	13	3	2			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr11:71293418T>G	uc001oqu.2	-	1	504	c.466A>C	c.(466-468)ATC>CTC	p.I156L		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	156						keratin filament					0						GAGCCTCAGATCTTACACTGG	0.308													G	71293418	G	G	71293418	3	3	217	1	0	0	0	0	1	0	0	0	8560	1435	50	5	8	5	KRTAP5-11	11	71293418	Missense_Mutation	SNP	T	TCGA-28-5218-01A-01D-1486-08	6717897	71293418	63713098	16	15208											
INPPL1	3636	broad.mit.edu	37	chr11	71942586	71942586	+	Frame_Shift_Del	DEL	C	-	-													atcaaggtggcagtgctggtCaagccagagcacgagaaccg							TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr11:71942586delC	uc001osf.2	+	13	1689	c.1542delC	c.(1540-1542)GTCfs	p.V514fs	INPPL1_uc001osg.2_Frame_Shift_Del_p.V272fs	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	514					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						CAGTGCTGGTCAAGCCAGAGC	0.567													-	71942586	-	-	71942586	7	5	217	1	0	1	0	1	0	0	0	0	7761	813	29	0	1592	0	INPPL1	11	71942586	Frame_Shift_Del	DEL	C	TCGA-28-5218-01A-01D-1486-08	649168	71942586	63063930	17	15209											
RAB30	27314	broad.mit.edu	37	chr11	82693315	82693315	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggcttcactgatgagtcgGcatgctaagtcaaggaagag	13	8	2	3			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr11:82693315G>A	uc001ozu.2	-	6	765	c.504C>T	c.(502-504)TGC>TGT	p.C168C	RAB30_uc009yve.2_Silent_p.C166C|RAB30_uc010rst.1_Silent_p.C166C|RAB30_uc001ozv.2_3'UTR	NM_014488	NP_055303	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	168					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity				0						TGATGAGTCGGCATGCTAAGT	0.438													A	82693315	A	A	82693315	2	1	217	1	0	0	0	0	0	0	0	1	12919	1195	42	3		3	RAB30	11	82693315	Silent	SNP	G	TCGA-28-5218-01A-01D-1486-08	10750729	82693315	52313201	18	15210											
SESN3	143686	broad.mit.edu	37	chr11	94924753	94924756	+	Frame_Shift_Del	DEL	TTGC	-	-													agtacgttcatccactgtgtTtgcttggacaaccttataac							TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr11:94924753_94924756delTTGC	uc001pfk.1	-	3	376_379	c.154_157delGCAA	c.(154-159)GCAAACfs	p.A52fs	SESN3_uc010rug.1_5'UTR|SESN3_uc001pfl.2_Frame_Shift_Del_p.A52fs	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	52_53					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TCCACTGTGTTTGCTTGGACAACC	0.368													-	94924756	-	-	94924753	7	5	217	1	0	1	0	1	0	0	0	0	14126	1841	64	0	1353	0	SESN3	11	94924753	Frame_Shift_Del	DEL	TTGC	TCGA-28-5218-01A-01D-1486-08	12231438	94924753	40081763	19	15211											
HELB	92797	broad.mit.edu	37	chr12	66698566	66698566	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaagtgtttggacgttttccGataacaggtgcttggtggag	14	5	0	0			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr12:66698566G>A	uc001sti.2	+	2	271	c.243G>A	c.(241-243)CCG>CCA	p.P81P	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	81					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		GACGTTTTCCGATAACAGGTG	0.378													A	66698566	A	A	66698566	2	1	217	1	0	0	0	0	0	0	0	1	7045	1045	37	2		2	HELB	12	66698566	Silent	SNP	G	TCGA-28-5218-01A-01D-1486-08		66698566	67153329	20	15212											
CABP1	9478	broad.mit.edu	37	chr12	121098105	121098105	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctacatgcccaccgagatGgagctcatcgaactgtccca	10	14	1	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr12:121098105G>A	uc001tyu.2	+	3	859	c.792G>A	c.(790-792)ATG>ATA	p.M264I	CABP1_uc001tyv.2_Missense_Mutation_p.M121I|CABP1_uc001tyw.2_Missense_Mutation_p.M61I|CABP1_uc001tyx.2_Missense_Mutation_p.M106I	NM_001033677	NP_001028849	Q9NZU7	CABP1_HUMAN	calcium binding protein 1 isoform 3	264	EF-hand 2.					cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCACCGAGATGGAGCTCATCG	0.542													A	121098105	A	A	121098105	3	1	217	1	0	0	0	0	1	0	0	0	2531	1348	47	3	1035	3	CABP1	12	121098105	Missense_Mutation	SNP	G	TCGA-28-5218-01A-01D-1486-08	54399539	121098105	12753790	21	15213											
HERC2	8924	broad.mit.edu	37	chr15	28389261	28389261	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacaagctgccagcgaggccGcaaggcgagggacgatgctt	15	12	0	0			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr15:28389261G>A	uc001zbj.2	-	73	11367	c.11261C>T	c.(11260-11262)GCG>GTG	p.A3754V		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3754					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CAGCGAGGCCGCAAGGCGAGG	0.537													A	28389261	A	A	28389261	3	1	217	1	0	0	0	0	1	0	0	0	7058	1087	38	1	3327	1	HERC2	15	28389261	Missense_Mutation	SNP	G	TCGA-28-5218-01A-01D-1486-08		28389261	74142131	22	15214											
MRPS34	65993	broad.mit.edu	37	chr16	1823074	1823075	+	Frame_Shift_Ins	INS	-	G	G													ccgcagggcgcgcacgcggcINSgggccagctccgcgatcagc							TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr16:1823074_1823075insG	uc002cmo.2	-	1	66_67	c.46_47insC	c.(46-48)CGCfs	p.R16fs	NME3_uc002cmm.2_5'Flank|NME3_uc010brv.2_5'Flank|MRPS34_uc002cmn.2_5'Flank|MRPS34_uc002cmp.1_Frame_Shift_Ins_p.R16fs|EME2_uc002cmq.1_5'Flank|EME2_uc010brw.1_5'Flank	NM_023936	NP_076425	P82930	RT34_HUMAN	mitochondrial ribosomal protein S34	16						mitochondrion|ribosome	protein binding			skin(2)	2						GCGCACGCGGCGGGCCAGCTCC	0.723													G	1823075	G	G	1823074	7	5	217	1	0	1	1	0	0	0	0	0	9843	768	27	0	621	0	MRPS34	16	1823074	Frame_Shift_Ins	INS	-	TCGA-28-5218-01A-01D-1486-08		1823074	88531679	23	15215											
RNF40	9810	broad.mit.edu	37	chr16	30774843	30774843	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaggggccaacatgtgatggGactcctctcccagagccggg	15	12	1	2			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr16:30774843G>A	uc002dzq.2	+	4	528	c.405G>A	c.(403-405)GGG>GGA	p.G135G	C16orf93_uc002dzm.2_5'Flank|C16orf93_uc002dzn.2_5'Flank|C16orf93_uc002dzo.2_5'Flank|C16orf93_uc002dzp.2_5'Flank|RNF40_uc010caa.2_Silent_p.G135G|RNF40_uc010cab.2_Silent_p.G135G|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Silent_p.G135G|RNF40_uc010vfb.1_Intron	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	135					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			CATGTGATGGGACTCCTCTCC	0.612													A	30774843	A	A	30774843	2	1	217	1	0	0	0	0	0	0	0	1	13493	1161	41	3		3	RNF40	16	30774843	Silent	SNP	G	TCGA-28-5218-01A-01D-1486-08	28951769	30774843	59579910	24	15216											
KRTAP1-1	81851	broad.mit.edu	37	chr17	39197186	39197186	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgtccacagtaggatgggCggcagcaggaggcctcggcg	17	11	0	0			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr17:39197186C>T	uc002hvw.1	-	1	528	c.464G>A	c.(463-465)CGC>CAC	p.R155H		NM_030967	NP_112229	Q07627	KRA11_HUMAN	keratin associated protein 1-1	155						extracellular region|keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GTAGGATGGGCGGCAGCAGGA	0.637													T	39197186	T	T	39197186	3	4	217	1	0	0	0	0	1	0	0	0	8502	768	27	1	73	1	KRTAP1-1	17	39197186	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08		39197186	41998024	25	15217											
C19orf10	56005	broad.mit.edu	37	chr19	4668644	4668644	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaggcgtaagtgaacataCacgtatatttgtcctagaga	11	6	0	3			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr19:4668644C>T	uc002may.2	-	2	257	c.188G>A	c.(187-189)TGT>TAT	p.C63Y		NM_019107	NP_061980	Q969H8	CS010_HUMAN	hypothetical protein LOC56005 precursor	63						ER-Golgi intermediate compartment|extracellular region					0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.015)		AGTGAACATACACGTATATTT	0.313													T	4668644	T	T	4668644	3	4	217	1	0	0	0	0	1	0	0	0	1908	478	17	3	353	3	C19orf10	19	4668644	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08		4668644	54460339	26	15218											
ZNF317	57693	broad.mit.edu	37	chr19	9267420	9267420	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcacacacccagtgttggttCccaggtgcactaagatctct	8	13	2	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr19:9267420C>T	uc002mku.2	+	3	433	c.158C>T	c.(157-159)TCC>TTC	p.S53F	ZNF317_uc010xkm.1_Silent_p.F94F|ZNF317_uc002mkv.2_5'UTR|ZNF317_uc002mkw.2_Missense_Mutation_p.S53F|ZNF317_uc002mkx.2_5'UTR|ZNF317_uc002mky.2_5'UTR	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGTGTTGGTTCCCAGGTGCAC	0.527													T	9267420	T	T	9267420	3	4	217	1	0	0	0	0	1	0	0	0	17832	855	30	3	164	3	ZNF317	19	9267420	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08	4598776	9267420	49861563	27	15219											
MAN2B1	4125	broad.mit.edu	37	chr19	12763065	12763065	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ggcctggtcactttcgttgtCacctatactggcgttgtacc	10	12	2	0			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr19:12763065C>G	uc002mub.2	-	16	2024	c.1948G>C	c.(1948-1950)GAC>CAC	p.D650H	MAN2B1_uc010dyv.1_Missense_Mutation_p.D649H	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	650					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						CTTTCGTTGTCACCTATACTG	0.597													G	12763065	G	G	12763065	3	3	217	1	0	0	0	0	1	0	0	0	9216	826	29	5	1123	5	MAN2B1	19	12763065	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08	3495645	12763065	46365918	28	15220											
TMEM147	10430	broad.mit.edu	37	chr19	36037641	36037641	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttgtcatgtcccggaatgCcggcaagggagagtacaaga	13	10	1	2			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr19:36037641C>T	uc002oaj.1	+	4	372	c.275C>T	c.(274-276)GCC>GTC	p.A92V	uc010eec.1_5'Flank|uc002oag.2_5'Flank|TMEM147_uc002oai.1_Missense_Mutation_p.A43V|TMEM147_uc002oak.1_Missense_Mutation_p.P2S	NM_032635	NP_116024	Q9BVK8	TM147_HUMAN	transmembrane protein 147	92						endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TCCCGGAATGCCGGCAAGGGA	0.572													T	36037641	T	T	36037641	3	4	217	1	0	0	0	0	1	0	0	0	16058	739	26	3	289	3	TMEM147	19	36037641	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08	23274576	36037641	23091342	29	15221											
EXOSC5	56915	broad.mit.edu	37	chr19	41895788	41895788	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaccaatgccatgcaggcgGcattcagacaacaggccagg	11	14	1	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr19:41895788G>A	uc002oqo.2	-	4	430	c.407C>T	c.(406-408)GCC>GTC	p.A136V	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Intron	NM_020158	NP_064543	Q9NQT4	EXOS5_HUMAN	exosome component Rrp46	136					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding				0						CATGCAGGCGGCATTCAGACA	0.448													A	41895788	A	A	41895788	3	1	217	1	0	0	0	0	1	0	0	0	5318	1203	42	3	312	3	EXOSC5	19	41895788	Missense_Mutation	SNP	G	TCGA-28-5218-01A-01D-1486-08	5858147	41895788	17233195	30	15222											
NLRP5	126206	broad.mit.edu	37	chr19	56539217	56539217	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtatggctgtggagggagtgTggaataggaagtcagtgttt	18	2	1	0			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr19:56539217T>A	uc002qmj.2	+	7	1618	c.1618T>A	c.(1618-1620)TGG>AGG	p.W540R	NLRP5_uc002qmi.2_Missense_Mutation_p.W521R	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	540	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GGAGGGAGTGTGGAATAGGAA	0.552													A	56539217	A	A	56539217	3	1	217	1	0	0	0	0	1	0	0	0	10480	1696	59	5	1644	5	NLRP5	19	56539217	Missense_Mutation	SNP	T	TCGA-28-5218-01A-01D-1486-08	14643429	56539217	2589766	31	15223											
SNRPB	6628	broad.mit.edu	37	chr20	2443779	2443779	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggtgggggaggacccccaCggccaggtgggtactgggtt	19	9	0	0			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chr20:2443779C>T	uc002wfz.1	-	5	678	c.515G>A	c.(514-516)CGT>CAT	p.R172H	SNRPB_uc002wga.1_Missense_Mutation_p.R172H|SNRPB_uc010zpv.1_Missense_Mutation_p.R93H|SNRPB_uc002wgb.2_Missense_Mutation_p.R172H|SNORD119_uc010gam.1_5'Flank	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	172				RG -> L (in Ref. 4).	histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						AGGACCCCCACGGCCAGGTGG	0.597													T	2443779	T	T	2443779	3	4	217	1	0	0	0	0	1	0	0	0	14861	536	19	1	234	1	SNRPB	20	2443779	Missense_Mutation	SNP	C	TCGA-28-5218-01A-01D-1486-08		2443779	60581741	32	15224											
OTC	5009	broad.mit.edu	37	chrX	38260629	38260629	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcccaattatcaatgggcTgtcagatttgtaccatccta	6	11	2	1			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chrX:38260629T>C	uc004def.3	+	5	702	c.488T>C	c.(487-489)CTG>CCG	p.L163P		NM_000531	NP_000522	P00480	OTC_HUMAN	ornithine carbamoyltransferase precursor	163					arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			ovary(1)|breast(1)	2					L-Citrulline(DB00155)|L-Ornithine(DB00129)	ATCAATGGGCTGTCAGATTTG	0.408													C	38260629	C	C	38260629	3	2	217	1	0	0	0	0	1	0	0	0	11301	1580	55	4	506	4	OTC	23	38260629	Missense_Mutation	SNP	T	TCGA-28-5218-01A-01D-1486-08		38260629	117009931	33	15225											
HUWE1	10075	broad.mit.edu	37	chrX	53569470	53569470	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgggtgattcctccctccGgacagacgcctctgactggc	11	15	1	3			TCGA-28-5218-01A-01D-1486-08	TCGA-28-5218-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	68008a98-3889-4dd2-bcf9-f1f6cbca6355	727e8e46-718d-4e44-96a1-ed3544500a07	g.chrX:53569470G>A	uc004dsp.2	-	74	11812	c.11410C>T	c.(11410-11412)CGG>TGG	p.R3804W	HUWE1_uc004dsn.2_Missense_Mutation_p.R2612W|HUWE1_uc004dsq.1_Missense_Mutation_p.R104W	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3804					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCCTCCCTCCGGACAGACGCC	0.502													A	53569470	A	A	53569470	3	1	217	1	0	0	0	0	1	0	0	0	7461	1115	39	2	1758	2	HUWE1	23	53569470	Missense_Mutation	SNP	G	TCGA-28-5218-01A-01D-1486-08	15308841	53569470	101701090	34	15226											
GABRD	2563	broad.mit.edu	37	chr1	1957086	1957086	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgcccgacaccttcatcGtgaacgccaagtcggcctgg	12	15	1	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr1:1957086G>A	uc001aip.2	+	4	474	c.379G>A	c.(379-381)GTG>ATG	p.V127M		NM_000815	NP_000806	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	127	Extracellular (Probable).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CACCTTCATCGTGAACGCCAA	0.637													A	1957086	A	A	1957086	3	1	218	1	0	0	0	0	1	0	0	0	6169	1145	40	1	393	1	GABRD	1	1957086	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08		1957086	247293535	1	15227											
RERE	473	broad.mit.edu	37	chr1	8419978	8419978	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttggccagcttggacccgGccagaggcatgaagtacagg	14	11	1	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr1:8419978G>A	uc001ape.2	-	20	4274	c.3464C>T	c.(3463-3465)GCC>GTC	p.A1155V	RERE_uc001apf.2_Missense_Mutation_p.A1155V|RERE_uc001apd.2_Missense_Mutation_p.A601V	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1155					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CTTGGACCCGGCCAGAGGCAT	0.562													A	8419978	A	A	8419978	3	1	218	1	0	0	0	0	1	0	0	0	13231	1203	42	3	1256	3	RERE	1	8419978	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	6462892	8419978	240830643	2	15228											
RERE	473	broad.mit.edu	37	chr1	8684379	8684379	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaacgcttaccagtttgaagTcttgaatgctacagatgaaa	8	7	1	4			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr1:8684379T>G	uc001ape.2	-	4	1196	c.386A>C	c.(385-387)GAC>GCC	p.D129A	RERE_uc001apf.2_Missense_Mutation_p.D129A|RERE_uc001aph.1_Missense_Mutation_p.D129A	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	129	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CAGTTTGAAGTCTTGAATGCT	0.383													G	8684379	G	G	8684379	3	3	218	1	0	0	0	0	1	0	0	0	13231	1667	58	5	4398	5	RERE	1	8684379	Missense_Mutation	SNP	T	TCGA-28-5219-01A-01D-1486-08	264401	8684379	240566242	3	15229											
KPNA6	23633	broad.mit.edu	37	chr1	32622514	32622514	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctgccatgttcgatagtcttCtcatggactcttatgtgagc	9	10	3	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr1:32622514C>A	uc001bug.2	+	3	287	c.199C>A	c.(199-201)CTC>ATC	p.L67I	KPNA6_uc001buh.2_5'UTR|KPNA6_uc010ogx.1_Missense_Mutation_p.L64I|KPNA6_uc010ogy.1_Missense_Mutation_p.L72I|KPNA6_uc009vtz.2_Missense_Mutation_p.L6I	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	67					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CGATAGTCTTCTCATGGACTC	0.468													A	32622514	A	A	32622514	3	1	218	1	0	0	0	0	1	0	0	0	8434	913	32	5	209	5	KPNA6	1	32622514	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	23938135	32622514	216628107	4	15230											
HPCA	3208	broad.mit.edu	37	chr1	33354728	33354728	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcacctttgacaccaacagcGatggcaccatagactttcgg	9	13	0	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr1:33354728G>A	uc001bwh.2	+	2	269	c.229G>A	c.(229-231)GAT>AAT	p.D77N		NM_002143	NP_002134	P84074	HPCA_HUMAN	hippocalcin	77	EF-hand 2.|1 (Potential).						actin binding|calcium ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CACCAACAGCGATGGCACCAT	0.547													A	33354728	A	A	33354728	3	1	218	1	0	0	0	0	1	0	0	0	7329	1058	37	2	231	2	HPCA	1	33354728	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	732214	33354728	215895893	5	15231											
JAK1	3716	broad.mit.edu	37	chr1	65301859	65301860	+	Frame_Shift_Ins	INS	-	AT	AT													aagaccagacgtcagaggcaINSatataaaatttagattgcat							TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr1:65301859_65301860insAT	uc001dbu.1	-	23	3428_3429	c.3179_3180insAT	c.(3178-3180)ATTfs	p.I1060fs	JAK1_uc009wam.1_Frame_Shift_Ins_p.I1048fs|JAK1_uc009wal.1_Frame_Shift_Ins_p.I237fs	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	1060	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		CGTCAGAGGCAATATAAAATTT	0.421			Mis		ALL								AT	65301860	AT	AT	65301859	7	5	218	1	0	1	1	0	0	0	0	0	7937	126	5	0	296	0	JAK1	1	65301859	Frame_Shift_Ins	INS	-	TCGA-28-5219-01A-01D-1486-08	31947131	65301859	183948762	6	15232											
CDC73	79577	broad.mit.edu	37	chr1	193099308	193099309	+	Frame_Shift_Ins	INS	-	AAATATT	AAATATT													aaattttggttttagactgaINSaaatattcctgtggttagaa							TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr1:193099308_193099309insAAATATT	uc001gtb.2	+	3	485_486	c.242_243insAAATATT	c.(241-243)GAAfs	p.E81fs		NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	81					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						TTTTAGACTGAAAATATTCCTG	0.287									Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				AAATATT	193099309	AAATATT	AAATATT	193099308	7	5	218	1	0	1	1	0	0	0	0	0	3085	246	9	0	252	0	CDC73	1	193099308	Frame_Shift_Ins	INS	-	TCGA-28-5219-01A-01D-1486-08	127797449	193099308	56151313	7	15233											
NAV1	89796	broad.mit.edu	37	chr1	201782286	201782286	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aggcccttgcttctttctgtCgtgtcccattggcattgagg	11	11	2	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr1:201782286C>T	uc001gwu.2	+	27	5578	c.5231C>T	c.(5230-5232)TCG>TTG	p.S1744L	NAV1_uc001gwx.2_Missense_Mutation_p.S1353L	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1747					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						TTCTTTCTGTCGTGTCCCATT	0.507													T	201782286	T	T	201782286	3	4	218	1	0	0	0	0	1	0	0	0	10183	893	31	2	5407	2	NAV1	1	201782286	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	8682978	201782286	47468335	8	15234											
RYR2	6262	broad.mit.edu	37	chr1	237936883	237936883	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttattgatgaacaaggacaaCggaatttctccaaagctatc	7	8	1	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr1:237936883C>T	uc001hyl.1	+	87	11830	c.11710C>T	c.(11710-11712)CGG>TGG	p.R3904W	RYR2_uc010pya.1_Missense_Mutation_p.R319W	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3904					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACAAGGACAACGGAATTTCTC	0.338													T	237936883	T	T	237936883	3	4	218	1	0	0	0	0	1	0	0	0	13769	527	19	1	12056	1	RYR2	1	237936883	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	36154597	237936883	11313738	9	15235											
RRM2	6241	broad.mit.edu	37	chr2	10264898	10264898	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagcccgctgtttctatggcTtccaaattgccatggaaaac	8	11	1	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr2:10264898T>C	uc002rah.2	+	5	681	c.490T>C	c.(490-492)TTC>CTC	p.F164L		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	164					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		TTTCTATGGCTTCCAAATTGC	0.383													C	10264898	C	C	10264898	3	2	218	1	0	0	0	0	1	0	0	0	13682	1609	56	4	688	4	RRM2	2	10264898	Missense_Mutation	SNP	T	TCGA-28-5219-01A-01D-1486-08		10264898	232934475	10	15236											
POLR1A	25885	broad.mit.edu	37	chr2	86272410	86272410	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atacattttacctttggagaTagcctgagcggctggttttc	10	8	0	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr2:86272410T>C	uc002sqs.2	-	21	3339	c.2960A>G	c.(2959-2961)TAT>TGT	p.Y987C	POLR1A_uc010ytb.1_Missense_Mutation_p.Y353C|POLR1A_uc002sqt.1_5'Flank	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	987					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						CCTTTGGAGATAGCCTGAGCG	0.522													C	86272410	C	C	86272410	3	2	218	1	0	0	0	0	1	0	0	0	12209	1406	49	4	2258	4	POLR1A	2	86272410	Missense_Mutation	SNP	T	TCGA-28-5219-01A-01D-1486-08	76007512	86272410	156926963	11	15237											
GLI2	2736	broad.mit.edu	37	chr2	121744096	121744096	+	Frame_Shift_Del	DEL	G	-	-													caccggttcgagcagctcaaGaaggagaagctcaagtcact							TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr2:121744096delG	uc010flp.2	+	12	2229	c.2199delG	c.(2197-2199)AAGfs	p.K733fs	GLI2_uc002tmq.1_Frame_Shift_Del_p.K405fs|GLI2_uc002tmr.1_Frame_Shift_Del_p.K388fs|GLI2_uc002tmt.3_Frame_Shift_Del_p.K405fs|GLI2_uc002tmu.3_Frame_Shift_Del_p.K388fs|GLI2_uc002tmw.1_Frame_Shift_Del_p.K716fs	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	733					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				AGCAGCTCAAGAAGGAGAAGC	0.647													-	121744096	-	-	121744096	7	5	218	1	0	1	0	1	0	0	0	0	6438	933	33	0	2245	0	GLI2	2	121744096	Frame_Shift_Del	DEL	G	TCGA-28-5219-01A-01D-1486-08	35471686	121744096	121455277	12	15238											
TTN	7273	broad.mit.edu	37	chr2	179438951	179438951	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagttggccttcagccaccGtccattaggaaggtctctct	10	12	3	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr2:179438951G>A	uc010zfg.1	-	275	64428	c.64204C>T	c.(64204-64206)CGG>TGG	p.R21402W	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R15097W|TTN_uc010zfi.1_Missense_Mutation_p.R15030W|TTN_uc010zfj.1_Missense_Mutation_p.R14905W	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22329							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R21402C(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGCCACCGTCCATTAGGA	0.413													A	179438951	A	A	179438951	3	1	218	1	0	0	0	0	1	0	0	0	16732	1144	40	1	36219	1	TTN	2	179438951	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	57694855	179438951	63760422	13	15239											
TTN	7273	broad.mit.edu	37	chr2	179466465	179466465	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tgtatttgcctgtatgagatCgtttacactccggaataata	8	7	0	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr2:179466465C>A	uc010zfg.1	-	235	47872	c.47648G>T	c.(47647-47649)CGA>CTA	p.R15883L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R9578L|TTN_uc010zfi.1_Missense_Mutation_p.R9511L|TTN_uc010zfj.1_Missense_Mutation_p.R9386L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16810							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTATGAGATCGTTTACACTC	0.363													A	179466465	A	A	179466465	3	1	218	1	0	0	0	0	1	0	0	0	16732	884	31	5	52649	5	TTN	2	179466465	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	27514	179466465	63732908	14	15240											
DNAH7	56171	broad.mit.edu	37	chr2	196825609	196825609	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccatcttggatttttttacGttgaggatatacagatggta	10	5	1	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr2:196825609G>A	uc002utj.3	-	18	2367	c.2266C>T	c.(2266-2268)CGT>TGT	p.R756C		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	756	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATTTTTTTACGTTGAGGATAT	0.368													A	196825609	A	A	196825609	3	1	218	1	0	0	0	0	1	0	0	0	4606	1145	40	1	10000	1	DNAH7	2	196825609	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	17359144	196825609	46373764	15	15241											
SUSD5	26032	broad.mit.edu	37	chr3	33194586	33194586	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgggtggttgccatgatcGttgaggggatgtggttaggt	19	4	0	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr3:33194586G>A	uc003cfo.1	-	5	1956	c.1538C>T	c.(1537-1539)ACG>ATG	p.T513M		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	513	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						TGCCATGATCGTTGAGGGGAT	0.522													A	33194586	A	A	33194586	3	1	218	1	0	0	0	0	1	0	0	0	15408	1145	40	1	355	1	SUSD5	3	33194586	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08		33194586	164827844	16	15242											
STAB1	23166	broad.mit.edu	37	chr3	52551109	52551109	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggatggctacatgggcgaCggggagctgtgccagggtga	19	8	0	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr3:52551109C>T	uc003dej.2	+	42	4547	c.4473C>T	c.(4471-4473)GAC>GAT	p.D1491D	STAB1_uc003dek.1_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1491	Extracellular (Potential).|EGF-like 11.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACATGGGCGACGGGGAGCTGT	0.622													T	52551109	T	T	52551109	2	4	218	1	0	0	0	0	0	0	0	1	15236	535	19	1		1	STAB1	3	52551109	Silent	SNP	C	TCGA-28-5219-01A-01D-1486-08	19356523	52551109	145471321	17	15243											
TMEM14E	645843	broad.mit.edu	37	chr3	152058532	152058532	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttggattccgtgatggctgAgaagcatccaggcctgctaa	12	9	0	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr3:152058532A>G	uc010hvo.2	-	1	248	c.162T>C	c.(160-162)TCT>TCC	p.S54S	MBNL1_uc003ezh.2_Intron|MBNL1_uc003ezi.2_Intron|MBNL1_uc003ezj.2_Intron|MBNL1_uc003ezm.2_Intron|MBNL1_uc003ezl.2_Intron|MBNL1_uc003ezp.2_Intron|MBNL1_uc003ezn.2_Intron|MBNL1_uc003ezo.2_Intron	NM_001123228	NP_001116700	Q6UXP3	TM14E_HUMAN	transmembrane protein 14E	54						integral to membrane					0						GTGATGGCTGAGAAGCATCCA	0.453													G	152058532	G	G	152058532	2	3	218	1	0	0	0	0	0	0	0	1	16063	291	11	4		4	TMEM14E	3	152058532	Silent	SNP	A	TCGA-28-5219-01A-01D-1486-08	99507423	152058532	45963898	18	15244											
PDE6B	5158	broad.mit.edu	37	chr4	619881	619881	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgaacgtcgaggacgtggccGaggtgggtctgtgcggagcc	19	9	1	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr4:619881G>A	uc003gap.2	+	1	519	c.466G>A	c.(466-468)GAG>AAG	p.E156K	PDE6B_uc003gao.3_Missense_Mutation_p.E156K	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	156	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						GGACGTGGCCGAGGTGGGTCT	0.642													A	619881	A	A	619881	3	1	218	1	0	0	0	0	1	0	0	0	11646	1059	37	2	468	2	PDE6B	4	619881	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08		619881	190534395	19	15245											
HS3ST1	9957	broad.mit.edu	37	chr4	11401266	11401266	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgggcgacgtgaaatacgCgggggtcttctccactgtga	14	9	2	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr4:11401266C>T	uc003gmq.2	-	2	687	c.364G>A	c.(364-366)GCG>ACG	p.A122T		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	122						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						GTGAAATACGCGGGGGTCTTC	0.612													T	11401266	T	T	11401266	3	4	218	1	0	0	0	0	1	0	0	0	7363	768	27	1	563	1	HS3ST1	4	11401266	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	10781385	11401266	179753010	20	15246											
UGT2A1	10941	broad.mit.edu	37	chr4	70455276	70455276	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcttggctcctttgtggcgCatgacaaactcgatccagaa	10	11	0	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr4:70455276C>T	uc003hem.3	-	6	1461	c.1398G>A	c.(1396-1398)ATG>ATA	p.M466I	UGT2A1_uc011caq.1_Missense_Mutation_p.M632I|UGT2A1_uc010ihu.2_Missense_Mutation_p.M466I|UGT2A1_uc010iht.2_Missense_Mutation_p.M422I|UGT2A1_uc010ihs.2_Missense_Mutation_p.M467I	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	466	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						CTTTGTGGCGCATGACAAACT	0.478													T	70455276	T	T	70455276	3	4	218	1	0	0	0	0	1	0	0	0	16950	710	25	3	189	3	UGT2A1	4	70455276	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	59054010	70455276	120699000	21	15247											
ODAM	54959	broad.mit.edu	37	chr4	71062419	71062419	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttacttttagcttatcccacAgcgtctcatgtctgccagca	6	13	2	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr4:71062419A>T	uc003hfc.2	+	2	79	c.62A>T	c.(61-63)CAG>CTG	p.Q21L		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	21					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						CTTATCCCACAGCGTCTCATG	0.333													T	71062419	T	T	71062419	3	4	218	1	0	0	0	0	1	0	0	0	10824	188	7	5	68	5	ODAM	4	71062419	Missense_Mutation	SNP	A	TCGA-28-5219-01A-01D-1486-08	607143	71062419	120091857	22	15248											
MAST4	375449	broad.mit.edu	37	chr5	66084566	66084566	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagagacgtccaacctcGtgcgcatgcgcagccaggcc	12	16	0	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr5:66084566G>A	uc003jur.3	+	3	894	c.586G>A	c.(586-588)GTG>ATG	p.V196M	MAST4_uc010iwz.2_Missense_Mutation_p.V196M	NM_198828	NP_942123	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	196						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GTCCAACCTCGTGCGCATGCG	0.657													A	66084566	A	A	66084566	3	1	218	1	0	0	0	0	1	0	0	0	9327	1145	40	1	596	1	MAST4	5	66084566	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08		66084566	114830694	23	15249											
PCDHA1	56147	broad.mit.edu	37	chr5	140167892	140167892	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtatctctggtggagagcGgccaggcgccaaaggcgtct	15	10	2	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr5:140167892G>A	uc003lhb.2	+	1	2017	c.2017G>A	c.(2017-2019)GGC>AGC	p.G673S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.G673S	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	673	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGAGAGCGGCCAGGCGCC	0.657													A	140167892	A	A	140167892	3	1	218	1	0	0	0	0	1	0	0	0	11519	1116	39	2	2019	2	PCDHA1	5	140167892	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	74083326	140167892	40747368	24	15250											
SLC44A4	80736	broad.mit.edu	37	chr6	31838592	31838592	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgggcaggacactcacgggCggccagccaggtctcctgca	15	14	2	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr6:31838592C>T	uc010jti.2	-	10	1000	c.934G>A	c.(934-936)GCC>ACC	p.A312T	SLC44A4_uc011dol.1_Missense_Mutation_p.A236T|SLC44A4_uc011dom.1_Missense_Mutation_p.A270T	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	312	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	CACTCACGGGCGGCCAGCCAG	0.692													T	31838592	T	T	31838592	3	4	218	1	0	0	0	0	1	0	0	0	14638	768	27	1	1246	1	SLC44A4	6	31838592	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08		31838592	139276475	25	15251											
COL19A1	1310	broad.mit.edu	37	chr6	70637867	70637867	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtttcgagtacgaagaaaCgccaaaaaggaacggtggtt	12	6	0	1	rs143252227	byFrequency	TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr6:70637867C>T	uc003pfc.1	+	5	450	c.333C>T	c.(331-333)AAC>AAT	p.N111N	COL19A1_uc010kam.1_Silent_p.N7N	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	111	TSP N-terminal.			FRVRRNAKKERWFL -> ETTVPFWRFFVLET (in Ref. 6; AAA36358).	cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TACGAAGAAACGCCAAAAAGG	0.428													T	70637867	T	T	70637867	2	4	218	1	0	0	0	0	0	0	0	1	3676	535	19	1		1	COL19A1	6	70637867	Silent	SNP	C	TCGA-28-5219-01A-01D-1486-08	38799275	70637867	100477200	26	15252											
AHR	196	broad.mit.edu	37	chr7	17378648	17378648	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcatttacgaaaacgaaataCgaagttgccttttatgttta	7	6	0	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:17378648C>T	uc011jxz.1	+	10	1812	c.1199C>T	c.(1198-1200)ACG>ATG	p.T400M	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	400					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AAACGAAATACGAAGTTGCCT	0.333													T	17378648	T	T	17378648	3	4	218	1	0	0	0	0	1	0	0	0	416	536	19	1	1237	1	AHR	7	17378648	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08		17378648	141760015	27	15253											
RABGEF1	27342	broad.mit.edu	37	chr7	66240279	66240279	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaggggcccaatccctcaCattctccaagtttgaagaaa	7	13	2	2	rs149995446	by1000genomes	TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:66240279C>T	uc011kee.1	+	3	451	c.287C>T	c.(286-288)ACA>ATA	p.T96I	RABGEF1_uc003tvf.2_5'UTR|RABGEF1_uc003tvg.2_5'UTR|RABGEF1_uc010lag.2_Missense_Mutation_p.T82I|RABGEF1_uc003tvh.2_Missense_Mutation_p.T82I|RABGEF1_uc003tvi.2_5'UTR	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	260					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						CAATCCCTCACATTCTCCAAG	0.483													T	66240279	T	T	66240279	3	4	218	1	0	0	0	0	1	0	0	0	12966	478	17	3	251	3	RABGEF1	7	66240279	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	48861631	66240279	92898384	28	15254											
PCLO	27445	broad.mit.edu	37	chr7	82784650	82784650	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgaactggagtctttgtaGgcccaggtgccttagctgga	14	9	1	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:82784650G>A	uc003uhx.2	-	2	1596	c.1307C>T	c.(1306-1308)CCT>CTT	p.P436L	PCLO_uc003uhv.2_Missense_Mutation_p.P436L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	388	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGTCTTTGTAGGCCCAGGTGC	0.587													A	82784650	A	A	82784650	3	1	218	1	0	0	0	0	1	0	0	0	11583	1000	35	3	14234	3	PCLO	7	82784650	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	16544371	82784650	76354013	29	15255											
SEMA3D	223117	broad.mit.edu	37	chr7	84671590	84671590	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttatcaggctgcgttgtccTcctacatcattctgacatga	7	11	3	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:84671590T>C	uc003uic.2	-	8	913	c.873A>G	c.(871-873)GGA>GGG	p.G291G	SEMA3D_uc010led.2_Silent_p.G291G|SEMA3D_uc003uib.2_5'Flank	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	291	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TGCGTTGTCCTCCTACATCAT	0.378													C	84671590	C	C	84671590	2	2	218	1	0	0	0	0	0	0	0	1	14027	1538	54	4		4	SEMA3D	7	84671590	Silent	SNP	T	TCGA-28-5219-01A-01D-1486-08	1886940	84671590	74467073	30	15256											
AKAP9	10142	broad.mit.edu	37	chr7	91708676	91708676	+	Frame_Shift_Del	DEL	C	-	-													aaccgctaatgaagaaatgaCcttcatgaaaaatgtactta							TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:91708676delC	uc003ulg.2	+	31	7454	c.7229delC	c.(7228-7230)ACCfs	p.T2410fs	AKAP9_uc003ulf.2_Frame_Shift_Del_p.T2402fs|AKAP9_uc003uli.2_Frame_Shift_Del_p.T2033fs|AKAP9_uc003ulj.2_Frame_Shift_Del_p.T180fs	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2422	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAAGAAATGACCTTCATGAAA	0.353			T	BRAF	papillary thyroid								-	91708676	-	-	91708676	7	5	218	1	0	1	0	1	0	0	0	0	459	507	18	0	7351	0	AKAP9	7	91708676	Frame_Shift_Del	DEL	C	TCGA-28-5219-01A-01D-1486-08	7037086	91708676	67429987	31	15257											
AP4M1	9179	broad.mit.edu	37	chr7	99702962	99702962	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctccgcttgcaaccacctcAgggcgaggtcagggttgggg	15	13	2	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:99702962A>T	uc003utb.3	+	10	1035	c.827A>T	c.(826-828)CAG>CTG	p.Q276L	AP4M1_uc011kjg.1_Missense_Mutation_p.Q230L|AP4M1_uc010lgl.1_Missense_Mutation_p.Q276L|AP4M1_uc003utc.3_Missense_Mutation_p.Q283L|AP4M1_uc010lgm.2_Missense_Mutation_p.Q148L|AP4M1_uc003utd.2_Missense_Mutation_p.Q276L|AP4M1_uc011kjh.1_Missense_Mutation_p.Q228L|AP4M1_uc003ute.3_Missense_Mutation_p.Q51L|AP4M1_uc003utf.3_Missense_Mutation_p.Q148L	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	276	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAACCACCTCAGGGCGAGGTC	0.552													T	99702962	T	T	99702962	3	4	218	1	0	0	0	0	1	0	0	0	753	188	7	5	865	5	AP4M1	7	99702962	Missense_Mutation	SNP	A	TCGA-28-5219-01A-01D-1486-08	7994286	99702962	59435701	32	15258											
RELN	5649	broad.mit.edu	37	chr7	103293088	103293088	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggagaacaggcaagacatggAaaaagtctacagcccagaca	11	9	1	3			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:103293088A>G	uc003vca.2	-	14	1833	c.1673T>C	c.(1672-1674)TTC>TCC	p.F558S	RELN_uc010liz.2_Missense_Mutation_p.F558S	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	558					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAAGACATGGAAAAAGTCTAC	0.448													G	103293088	G	G	103293088	3	3	218	1	0	0	0	0	1	0	0	0	13220	246	9	4	8917	4	RELN	7	103293088	Missense_Mutation	SNP	A	TCGA-28-5219-01A-01D-1486-08	3590126	103293088	55845575	33	15259											
REPIN1	29803	broad.mit.edu	37	chr7	150068992	150068992	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggcccaggggccgccccgCggtgaccgccccccggcccg	15	23	0	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:150068992C>T	uc010lpq.1	+	4	1151	c.662C>T	c.(661-663)GCG>GTG	p.A221V	REPIN1_uc003whd.2_Missense_Mutation_p.A210V|REPIN1_uc010lpr.1_Missense_Mutation_p.A278V|REPIN1_uc003whc.2_Missense_Mutation_p.A221V|REPIN1_uc003whe.2_Missense_Mutation_p.A221V	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	221					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			ggccgccccgcggtgaccgcc	0.488													T	150068992	T	T	150068992	3	4	218	1	0	0	0	0	1	0	0	0	13227	768	27	1	839	1	REPIN1	7	150068992	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	46775904	150068992	9069671	34	15260											
MLL3	58508	broad.mit.edu	37	chr7	151904459	151904459	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccttagtttcatcatccacaGcttcccgctcaggactagat	6	14	3	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:151904459G>C	uc003wla.2	-	24	3986	c.3767C>G	c.(3766-3768)GCT>GGT	p.A1256G	MLL3_uc003wkz.2_Missense_Mutation_p.A317G	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1256					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATCATCCACAGCTTCCCGCTC	0.393			N		medulloblastoma								C	151904459	C	C	151904459	3	2	218	1	0	0	0	0	1	0	0	0	9622	971	34	5	11112	5	MLL3	7	151904459	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	1835467	151904459	7234204	35	15261											
UBE3C	9690	broad.mit.edu	37	chr7	157000142	157000142	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caggggttctcctatgtcttTtgaagattctagtcgaatca	9	8	4	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr7:157000142T>C	uc010lqs.2	+	12	1781	c.1469T>C	c.(1468-1470)TTT>TCT	p.F490S	UBE3C_uc003wng.2_Missense_Mutation_p.F490S	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	490					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		CCTATGTCTTTTGAAGATTCT	0.358													C	157000142	C	C	157000142	3	2	218	1	0	0	0	0	1	0	0	0	16878	1841	64	4	1515	4	UBE3C	7	157000142	Missense_Mutation	SNP	T	TCGA-28-5219-01A-01D-1486-08	5095683	157000142	2138521	36	15262											
SGK223	157285	broad.mit.edu	37	chr8	8234543	8234543	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagttgggtctgggctgtccCggccccagccagatgctgct	15	13	1	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr8:8234543C>T	uc003wsh.3	-	2	1376	c.1376G>A	c.(1375-1377)CGG>CAG	p.R459Q		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	459							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TGGGCTGTCCCGGCCCCAGCC	0.622													T	8234543	T	T	8234543	3	4	218	1	0	0	0	0	1	0	0	0	14210	652	23	2	2848	2	SGK223	8	8234543	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08		8234543	138129479	37	15263											
CNTNAP3	79937	broad.mit.edu	37	chr9	39140559	39140559	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aatggtcccagggggccactTccatctgcatcaatatagta	9	11	2	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr9:39140559T>A	uc004abi.2	-	12	2072	c.1833A>T	c.(1831-1833)GGA>GGT	p.G611G	CNTNAP3_uc004abj.2_Silent_p.G611G|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Silent_p.G611G|CNTNAP3_uc011lqs.1_Silent_p.G518G|CNTNAP3_uc004abl.1_Silent_p.G430G	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	611	Fibrinogen C-terminal.|Extracellular (Potential).				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GGGGGCCACTTCCATCTGCAT	0.453													A	39140559	A	A	39140559	2	1	218	1	0	0	0	0	0	0	0	1	3648	1770	62	5		5	CNTNAP3	9	39140559	Silent	SNP	T	TCGA-28-5219-01A-01D-1486-08		39140559	102072872	38	15264											
ZNF618	114991	broad.mit.edu	37	chr9	116810979	116810979	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgatccccgaaaaggagcGgcagaacatcgcagagcggc	13	12	0	3			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr9:116810979G>A	uc004bid.2	+	15	1496	c.1397G>A	c.(1396-1398)CGG>CAG	p.R466Q	ZNF618_uc004bic.2_Missense_Mutation_p.R373Q|ZNF618_uc011lxi.1_Missense_Mutation_p.R433Q|ZNF618_uc011lxj.1_Missense_Mutation_p.R434Q|ZNF618_uc010mvb.2_Missense_Mutation_p.R56Q	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAAAGGAGCGGCAGAACATC	0.552													A	116810979	A	A	116810979	3	1	218	1	0	0	0	0	1	0	0	0	18039	1116	39	2	1172	2	ZNF618	9	116810979	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	77670420	116810979	24402452	39	15265											
PNPLA7	375775	broad.mit.edu	37	chr9	140389550	140389550	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttggccaattctgagtcccGaacggcatgcaccgtggtcg	12	13	1	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr9:140389550G>A	uc004cnf.2	-	18	2324	c.1987C>T	c.(1987-1989)CGG>TGG	p.R663W	C9orf167_uc011mew.1_Intron|PNPLA7_uc011mfa.1_Intron|PNPLA7_uc010ncj.1_Missense_Mutation_p.R688W	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	663	cNMP 3.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TCTGAGTCCCGAACGGCATGC	0.687													A	140389550	A	A	140389550	3	1	218	1	0	0	0	0	1	0	0	0	12170	1057	37	2	2034	2	PNPLA7	9	140389550	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	23578571	140389550	823881	40	15266											
C10orf2	56652	broad.mit.edu	37	chr10	102748161	102748161	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaaatccgccagtatttgcGggggcatgggatccccttcc	12	12	0	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr10:102748161G>A	uc001ksf.2	+	1	869	c.194G>A	c.(193-195)CGG>CAG	p.R65Q	MRPL43_uc001kry.1_5'Flank|MRPL43_uc010qpu.1_5'Flank|MRPL43_uc001krz.1_5'Flank|MRPL43_uc001ksa.1_5'Flank|MRPL43_uc001ksb.1_5'Flank|MRPL43_uc001ksd.1_5'Flank|MRPL43_uc001ksc.2_5'Flank|MRPL43_uc001kse.2_5'Flank|C10orf2_uc001ksg.2_Missense_Mutation_p.R65Q|C10orf2_uc001ksi.2_Intron|C10orf2_uc010qpv.1_Intron|C10orf2_uc001ksh.2_Intron	NM_021830	NP_068602	Q96RR1	PEO1_HUMAN	twinkle isoform A	65					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			ovary(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		CAGTATTTGCGGGGGCATGGG	0.572													A	102748161	A	A	102748161	3	1	218	1	0	0	0	0	1	0	0	0	1597	1116	39	2	196	2	C10orf2	10	102748161	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08		102748161	32786586	41	15267											
OR5L2	26338	broad.mit.edu	37	chr11	55594981	55594981	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caaagccatctccttcctagGgtgcatggtgcaattctact	8	12	2	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr11:55594981G>T	uc001nhy.1	+	1	287	c.287G>T	c.(286-288)GGG>GTG	p.G96V		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TCCTTCCTAGGGTGCATGGTG	0.473										HNSCC(27;0.073)			T	55594981	T	T	55594981	3	4	218	1	0	0	0	0	1	0	0	0	11171	1232	43	5	289	5	OR5L2	11	55594981	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08		55594981	79411535	42	15268											
MED17	9440	broad.mit.edu	37	chr11	93543034	93543034	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctccccaagtggtgactatgCtatttcaggtactttctgct	8	11	2	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr11:93543034C>A	uc001pem.3	+	11	2011	c.1736C>A	c.(1735-1737)GCT>GAT	p.A579D		NM_004268	NP_004259	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	579					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GGTGACTATGCTATTTCAGGT	0.408													A	93543034	A	A	93543034	3	1	218	1	0	0	0	0	1	0	0	0	9435	797	28	5	1778	5	MED17	11	93543034	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	37948053	93543034	41463482	43	15269											
KRT18	3875	broad.mit.edu	37	chr12	53345364	53345364	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaagatcatggcagacatcCgggcccaatatgacgagctg	11	12	1	3			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr12:53345364C>T	uc001sbe.2	+	5	826	c.757C>T	c.(757-759)CGG>TGG	p.R253W	KRT18_uc009zmn.1_Missense_Mutation_p.R253W|KRT18_uc001sbf.1_Missense_Mutation_p.R80W|KRT18_uc001sbg.2_Missense_Mutation_p.R253W|KRT18_uc009zmo.2_Missense_Mutation_p.R253W|KRT8_uc009zml.1_5'Flank|KRT8_uc009zmm.1_5'Flank	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	253	Interaction with DNAJB6.|Coil 2.|Rod.|Necessary for interaction with PNN.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						GGCAGACATCCGGGCCCAATA	0.582													T	53345364	T	T	53345364	3	4	218	1	0	0	0	0	1	0	0	0	8455	643	23	2	771	2	KRT18	12	53345364	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08		53345364	80506531	44	15270											
C12orf12	196477	broad.mit.edu	37	chr12	91347528	91347528	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cctcttccagctcctcctctCcctcctccacatattcagcc	2	22	3	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr12:91347528C>G	uc001tbj.2	-	1	1426	c.992G>C	c.(991-993)GGA>GCA	p.G331A		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	331	Potential.|Glu-rich.									central_nervous_system(1)|pancreas(1)	2						ctcctcctctccctcctccac	0.184													G	91347528	G	G	91347528	3	3	218	1	0	0	0	0	1	0	0	0	1676	855	30	5	232	5	C12orf12	12	91347528	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	38002164	91347528	42504367	45	15271											
FOXN4	121643	broad.mit.edu	37	chr12	109719317	109719317	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agcccttcccatggcggggtGggggagcgggctggggctga	21	10	0	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr12:109719317G>T	uc001toe.3	-	9	1294	c.1189C>A	c.(1189-1191)CAC>AAC	p.H397N	FOXN4_uc009zvg.2_Missense_Mutation_p.H194N|FOXN4_uc001tof.3_Missense_Mutation_p.H217N	NM_213596	NP_998761	Q96NZ1	FOXN4_HUMAN	forkhead box N4	397					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|lung(1)	2						ATGGCGGGGTGGGGGAGCGGG	0.647													T	109719317	T	T	109719317	3	4	218	1	0	0	0	0	1	0	0	0	6022	1348	47	5	372	5	FOXN4	12	109719317	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	18371789	109719317	24132578	46	15272											
HVCN1	84329	broad.mit.edu	37	chr12	111099035	111099035	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaaggggggccctgggtgcGgggccaggggcaggggcaac	22	10	1	0	rs138491014		TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr12:111099035G>A	uc001trs.1	-	4	405	c.240C>T	c.(238-240)CCC>CCT	p.P80P	HVCN1_uc001trq.1_Silent_p.P80P|HVCN1_uc001trt.1_Silent_p.P80P|HVCN1_uc010syd.1_Silent_p.P60P	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	80	Cytoplasmic (Potential).				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						CCCTGGGTGCGGGGCCAGGGG	0.567													A	111099035	A	A	111099035	2	1	218	1	0	0	0	0	0	0	0	1	7462	1103	39	2		2	HVCN1	12	111099035	Silent	SNP	G	TCGA-28-5219-01A-01D-1486-08	1379718	111099035	22752860	47	15273											
KNTC1	9735	broad.mit.edu	37	chr12	123097664	123097664	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttttggtttttcagacattAggtatgcatcagttaacttt	7	6	2	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr12:123097664A>G	uc001ucv.2	+	54	5791	c.5628A>G	c.(5626-5628)TTA>TTG	p.L1876L	KNTC1_uc010taf.1_Silent_p.L801L	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1876					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTCAGACATTAGGTATGCATC	0.373													G	123097664	G	G	123097664	2	3	218	1	0	0	0	0	0	0	0	1	8428	417	15	4		4	KNTC1	12	123097664	Silent	SNP	A	TCGA-28-5219-01A-01D-1486-08	11998629	123097664	10754231	48	15274											
C13orf27	93081	broad.mit.edu	37	chr13	103418858	103418858	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcctttcactgccatggAatgatttgccttctcaatcc	6	14	2	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr13:103418858A>G	uc001vpo.2	-	6	755	c.577T>C	c.(577-579)TCC>CCC	p.S193P	C13orf27_uc001vpn.2_Missense_Mutation_p.S152P|C13orf27_uc001vpp.2_Missense_Mutation_p.S152P	NM_138779	NP_620134	Q5JUR7	CM027_HUMAN	hypothetical protein LOC93081	193											0	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ACTGCCATGGAATGATTTGCC	0.368													G	103418858	G	G	103418858	3	3	218	1	0	0	0	0	1	0	0	0	1723	246	9	4	110	4	C13orf27	13	103418858	Missense_Mutation	SNP	A	TCGA-28-5219-01A-01D-1486-08		103418858	11751020	49	15275											
GTF3C1	2975	broad.mit.edu	37	chr16	27499713	27499713	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggagcctactcttgcttcccCccaaatattcaacctgctgt	6	15	2	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr16:27499713C>G	uc002dov.1	-	23	3575	c.3535G>C	c.(3535-3537)GGG>CGG	p.G1179R	GTF3C1_uc002dou.2_Missense_Mutation_p.G1179R	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1179						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CTTGCTTCCCCCCAAATATTC	0.552													G	27499713	G	G	27499713	3	3	218	1	0	0	0	0	1	0	0	0	6872	623	22	5	2854	5	GTF3C1	16	27499713	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08		27499713	62855040	50	15276											
RPAIN	84268	broad.mit.edu	37	chr17	5329307	5329307	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcagagcagtccatcatcagCgagtatgagaagagcttgca	12	9	2	3	rs142664022	byFrequency	TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr17:5329307C>A	uc002gbq.2	+	4	900	c.330C>A	c.(328-330)AGC>AGA	p.S110R	RPAIN_uc010vsz.1_Missense_Mutation_p.S110R|RPAIN_uc002gbp.1_Intron|RPAIN_uc010vta.1_Intron|RPAIN_uc010vtb.1_Missense_Mutation_p.S110R|RPAIN_uc002gbs.2_Intron|RPAIN_uc002gbt.2_Missense_Mutation_p.S110R|RPAIN_uc002gbu.2_Intron|RPAIN_uc002gbv.2_Intron|RPAIN_uc002gbr.2_RNA|RPAIN_uc002gbw.2_Intron|RPAIN_uc002gbx.1_5'Flank	NM_001033002	NP_001028174	Q86UA6	RIP_HUMAN	RPA interacting protein isoform b	110					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|cytoplasm|nucleolus|PML body|PML body	metal ion binding|protein complex binding				0						CCATCATCAGCGAGTATGAGA	0.478													A	5329307	A	A	5329307	3	1	218	1	0	0	0	0	1	0	0	0	13540	767	27	5	344	5	RPAIN	17	5329307	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08		5329307	75865903	51	15277											
TP53	7157	broad.mit.edu	37	chr17	7579699	7579699	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcccaacccttgtccttaCcagaacgttgttttcaggaa	7	13	1	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr17:7579699C>T	uc002gim.2	-	3	290	c.96_splice	c.e3+1	p.L32_splice	TP53_uc002gig.1_Splice_Site_p.L32_splice|TP53_uc002gih.2_Splice_Site_p.L32_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Splice_Site_p.L32_splice|TP53_uc010cni.1_Splice_Site_p.L32_splice|TP53_uc002gij.2_Splice_Site_p.L32_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Splice_Site_p.L32_splice|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Splice_Site|TP53_uc010cnk.1_Splice_Site_p.L47_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(2)|p.S33fs*10(1)|p.P13fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTGTCCTTACCAGAACGTTG	0.383		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7579699	T	T	7579699	5	4	218	1	0	0	0	0	0	0	1	0	16378	521	18	3	1209	3	TP53	17	7579699	Splice_Site	SNP	C	TCGA-28-5219-01A-01D-1486-08	2250392	7579699	73615511	52	15278											
MBD3	53615	broad.mit.edu	37	chr19	1578435	1578435	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgcaggccttgtccagcggCgcctccccgtcacgggccag	14	18	1	0	rs150880184		TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr19:1578435C>T	uc002ltl.1	-	6	802	c.780G>A	c.(778-780)GCG>GCA	p.A260A	uc002lti.1_5'Flank|MBD3_uc002ltj.2_Silent_p.A260A|MBD3_uc002ltk.2_Silent_p.A228A	NM_003926	NP_003917	O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	260					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			ovary(1)|pancreas(1)|skin(1)	3		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTCCAGCGGCGCCTCCCCGT	0.557													T	1578435	T	T	1578435	2	4	218	1	0	0	0	0	0	0	0	1	9344	755	27	1		1	MBD3	19	1578435	Silent	SNP	C	TCGA-28-5219-01A-01D-1486-08		1578435	57550548	53	15279											
NOTCH3	4854	broad.mit.edu	37	chr19	15280951	15280951	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccagtctgtggccacctcCcccatcaggctctcaccctt	6	19	3	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr19:15280951C>T	uc002nan.2	-	28	5221	c.5145G>A	c.(5143-5145)GGG>GGA	p.G1715G		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1715	Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TGGCCACCTCCCCCATCAGGC	0.627													T	15280951	T	T	15280951	2	4	218	1	0	0	0	0	0	0	0	1	10550	610	22	3		3	NOTCH3	19	15280951	Silent	SNP	C	TCGA-28-5219-01A-01D-1486-08	13702516	15280951	43848032	54	15280											
FKBP8	23770	broad.mit.edu	37	chr19	18648452	18648452	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgatgttgtctggctggtGctccagcacaaggctgcagg	14	10	1	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr19:18648452G>A	uc002njk.1	-	6	1014	c.901C>T	c.(901-903)CAC>TAC	p.H301Y	FKBP8_uc002nji.1_Missense_Mutation_p.H139Y|FKBP8_uc010xqi.1_Missense_Mutation_p.H330Y|FKBP8_uc002njj.1_Missense_Mutation_p.H302Y|FKBP8_uc002njl.1_Missense_Mutation_p.H302Y|FKBP8_uc002njm.1_Missense_Mutation_p.H301Y|FKBP8_uc010ebr.1_Missense_Mutation_p.H140Y|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	301	TPR 2.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						TCTGGCTGGTGCTCCAGCACA	0.642													A	18648452	A	A	18648452	3	1	218	1	0	0	0	0	1	0	0	0	5914	1319	46	3	353	3	FKBP8	19	18648452	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08	3367501	18648452	40480531	55	15281											
NFKBIB	4793	broad.mit.edu	37	chr19	39398200	39398200	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcccaaccccatcctcgcCcgcctcctccgtgcacacgg	8	23	0	0			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr19:39398200C>T	uc002ojw.2	+	5	928	c.870C>T	c.(868-870)GCC>GCT	p.A290A	NFKBIB_uc002ojx.2_Silent_p.A258A|NFKBIB_uc002ojy.2_Silent_p.A290A	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	290	ANK 6.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CCATCCTCGCCCGCCTCCTCC	0.706													T	39398200	T	T	39398200	2	4	218	1	0	0	0	0	0	0	0	1	10378	610	22	3		3	NFKBIB	19	39398200	Silent	SNP	C	TCGA-28-5219-01A-01D-1486-08	20749748	39398200	19730783	56	15282											
AXL	558	broad.mit.edu	37	chr19	41744401	41744401	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgggcccccctgagaacattAgtgctacgcggaatgggagc	14	11	0	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr19:41744401A>G	uc010ehj.2	+	8	1211	c.1021A>G	c.(1021-1023)AGT>GGT	p.S341G	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Missense_Mutation_p.S341G|AXL_uc010ehk.2_Missense_Mutation_p.S341G	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	341	Extracellular (Potential).|Fibronectin type-III 2.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						TGAGAACATTAGTGCTACGCG	0.657													G	41744401	G	G	41744401	3	3	218	1	0	0	0	0	1	0	0	0	1238	420	15	4	1051	4	AXL	19	41744401	Missense_Mutation	SNP	A	TCGA-28-5219-01A-01D-1486-08	2346201	41744401	17384582	57	15283											
C20orf85	128602	broad.mit.edu	37	chr20	56728664	56728664	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cccagaactgggggtttttaAcaaccccttttgaggaggta	11	9	0	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr20:56728664A>T	uc002xyv.2	+	2	171	c.133A>T	c.(133-135)ACA>TCA	p.T45S		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	45										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			GGGGTTTTTAACAACCCCTTT	0.433													T	56728664	T	T	56728664	3	4	218	1	0	0	0	0	1	0	0	0	2120	43	2	5	139	5	C20orf85	20	56728664	Missense_Mutation	SNP	A	TCGA-28-5219-01A-01D-1486-08		56728664	6296856	58	15284											
TMPRSS15	5651	broad.mit.edu	37	chr21	19713765	19713765	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gaggagttggcaccaaagttGgttctggataaagactccca	12	8	1	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr21:19713765G>C	uc002ykw.2	-	13	1560	c.1529C>G	c.(1528-1530)CCA>CGA	p.P510R		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	510	Extracellular (Potential).				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CACCAAAGTTGGTTCTGGATA	0.328													C	19713765	C	C	19713765	3	2	218	1	0	0	0	0	1	0	0	0	16243	1348	47	5	1582	5	TMPRSS15	21	19713765	Missense_Mutation	SNP	G	TCGA-28-5219-01A-01D-1486-08		19713765	28416130	59	15285											
RIPK4	54101	broad.mit.edu	37	chr21	43161460	43161460	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgccagcaggctgcagacGttgacgtcggagcacaggtc	15	11	0	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr21:43161460G>A	uc002yzn.1	-	8	1941	c.1893C>T	c.(1891-1893)AAC>AAT	p.N631N		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	631						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GGCTGCAGACGTTGACGTCGG	0.697													A	43161460	A	A	43161460	2	1	218	1	0	0	0	0	0	0	0	1	13383	1136	40	1		1	RIPK4	21	43161460	Silent	SNP	G	TCGA-28-5219-01A-01D-1486-08	23447695	43161460	4968435	60	15286											
PRAME	23532	broad.mit.edu	37	chr22	22892481	22892481	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagcttcttacagcacaggCgtagtacatttttctttcgc	7	11	3	0	rs116965324	by1000genomes	TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr22:22892481C>T	uc002zwf.2	-	4	776	c.620G>A	c.(619-621)CGC>CAC	p.R207H	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Missense_Mutation_p.R191H|PRAME_uc010gtr.2_Missense_Mutation_p.R207H|PRAME_uc002zwg.2_Missense_Mutation_p.R207H|PRAME_uc002zwh.2_Missense_Mutation_p.R207H|PRAME_uc002zwi.2_Missense_Mutation_p.R207H|PRAME_uc002zwj.2_Missense_Mutation_p.R207H|PRAME_uc002zwk.2_Missense_Mutation_p.R207H	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	207					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		ACAGCACAGGCGTAGTACATT	0.443													T	22892481	T	T	22892481	3	4	218	1	0	0	0	0	1	0	0	0	12424	768	27	1	917	1	PRAME	22	22892481	Missense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08		22892481	28412085	61	15287											
DEPDC5	9681	broad.mit.edu	37	chr22	32239092	32239092	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctgttaggccttgtgtccCgaaaccgccctgaggaggag	13	11	1	1			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chr22:32239092C>T	uc003als.2	+	28	2642	c.2500C>T	c.(2500-2502)CGA>TGA	p.R834*	DEPDC5_uc011als.1_Nonsense_Mutation_p.R765*|DEPDC5_uc011alu.1_Nonsense_Mutation_p.R843*|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Nonsense_Mutation_p.R834*|DEPDC5_uc003alu.2_Nonsense_Mutation_p.R283*|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Nonsense_Mutation_p.R164*|DEPDC5_uc003alw.2_Nonsense_Mutation_p.R132*|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_5'Flank	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	834					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						CCTTGTGTCCCGAAACCGCCC	0.433													T	32239092	T	T	32239092	4	4	218	1	0	0	0	0	0	1	0	0	4442	644	23	2	2624	2	DEPDC5	22	32239092	Nonsense_Mutation	SNP	C	TCGA-28-5219-01A-01D-1486-08	9346611	32239092	19065474	62	15288											
ZCCHC13	389874	broad.mit.edu	37	chrX	73524398	73524398	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acctgcggcagactaggacaTctggctcgtgactgtgatcg	13	11	1	3			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chrX:73524398T>A	uc004ebs.3	+	1	374	c.297T>A	c.(295-297)CAT>CAA	p.H99Q		NM_203303	NP_976048	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	99	CCHC-type 4.						nucleic acid binding|zinc ion binding				0						GACTAGGACATCTGGCTCGTG	0.512													A	73524398	A	A	73524398	3	1	218	1	0	0	0	0	1	0	0	0	17579	1432	50	5	299	5	ZCCHC13	23	73524398	Missense_Mutation	SNP	T	TCGA-28-5219-01A-01D-1486-08		73524398	81746162	63	15289											
MAGEA12	4111	broad.mit.edu	37	chrX	151900252	151900252	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaggccatcgtaggagagGcccaggcaggtgacaaggat	16	9	0	2			TCGA-28-5219-01A-01D-1486-08	TCGA-28-5219-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f016e9f7-66a3-4f50-b9cd-58b1c8a955e9	3ac55487-c16b-43e7-932d-65f6039a33fa	g.chrX:151900252G>A	uc010ntp.2	-	3	903	c.549C>T	c.(547-549)GGC>GGT	p.G183G	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Silent_p.G183G|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	183	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CGTAGGAGAGGCCCAGGCAGG	0.577													A	151900252	A	A	151900252	2	1	218	1	0	0	0	0	0	0	0	1	9166	1190	42	3		3	MAGEA12	23	151900252	Silent	SNP	G	TCGA-28-5219-01A-01D-1486-08	78375854	151900252	3370308	64	15290											
VPS13D	55187	broad.mit.edu	37	chr1	12371650	12371650	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacccatagaggaatttatgCggccttatgatttacaagat	8	7	0	3			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr1:12371650C>T	uc001atv.2	+	28	6931	c.6790C>T	c.(6790-6792)CGG>TGG	p.R2264W	VPS13D_uc001atw.2_Missense_Mutation_p.R2264W|VPS13D_uc001atx.2_Missense_Mutation_p.R1452W|VPS13D_uc001aty.1_Missense_Mutation_p.R2W	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2264					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GGAATTTATGCGGCCTTATGA	0.438													T	12371650	T	T	12371650	3	4	219	1	0	0	0	0	1	0	0	0	17189	759	27	1	6896	1	VPS13D	1	12371650	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08		12371650	236878971	1	15291											
SLC2A1	6513	broad.mit.edu	37	chr1	43396818	43396818	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagcgtggtgagcgtggtGggcaggatgctctccccata	16	10	1	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr1:43396818G>A	uc001cik.2	-	3	699	c.174C>T	c.(172-174)CCC>CCT	p.P58P		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	58	Extracellular (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	TGAGCGTGGTGGGCAGGATGC	0.602											OREG0013425	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	43396818	A	A	43396818	2	1	219	1	0	0	0	0	0	0	0	1	14538	1335	47	3		3	SLC2A1	1	43396818	Silent	SNP	G	TCGA-28-5220-01A-01D-1486-08	31025168	43396818	205853803	2	15292											
TGFBR3	7049	broad.mit.edu	37	chr1	92178062	92178062	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agataaagcacgtttggatgGcaaatcccagttcttgttca	9	8	2	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr1:92178062G>A	uc001doh.2	-	13	2370	c.1904C>T	c.(1903-1905)GCC>GTC	p.A635V	TGFBR3_uc009wde.2_Intron|TGFBR3_uc010osy.1_Missense_Mutation_p.A593V|TGFBR3_uc001doi.2_Missense_Mutation_p.A634V|TGFBR3_uc001doj.2_Missense_Mutation_p.A634V	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	635	ZP.|Extracellular (Potential).		A -> T.		BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		CGTTTGGATGGCAAATCCCAG	0.368													A	92178062	A	A	92178062	3	1	219	1	0	0	0	0	1	0	0	0	15820	1203	42	3	671	3	TGFBR3	1	92178062	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08	48781244	92178062	157072559	3	15293											
NT5C1B	93034	broad.mit.edu	37	chr2	18764143	18764143	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attttacttaccgtagtgatTgacgctgtttataagccgca	8	8	0	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr2:18764143T>C	uc002rcz.2	-	7	1296	c.1192A>G	c.(1192-1194)AAT>GAT	p.N398D	NT5C1B_uc002rcy.2_Missense_Mutation_p.N398D|NT5C1B_uc010exr.2_Missense_Mutation_p.N340D|NT5C1B_uc010yju.1_Missense_Mutation_p.N338D|NT5C1B_uc002rda.2_Missense_Mutation_p.N338D|NT5C1B_uc010yjv.1_Missense_Mutation_p.N415D|NT5C1B_uc010yjw.1_Missense_Mutation_p.N381D|NT5C1B_uc010exs.2_Missense_Mutation_p.N400D	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	398					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CCGTAGTGATTGACGCTGTTT	0.413													C	18764143	C	C	18764143	3	2	219	1	0	0	0	0	1	0	0	0	10686	1812	63	4	656	4	NT5C1B	2	18764143	Missense_Mutation	SNP	T	TCGA-28-5220-01A-01D-1486-08		18764143	224435230	4	15294											
TGFBRAP1	9392	broad.mit.edu	37	chr2	105897164	105897164	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagagagatcagctcccggaCatcaagctggccgcttctgc	12	13	3	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr2:105897164C>T	uc002tcq.2	-	6	1222	c.1138G>A	c.(1138-1140)GTC>ATC	p.V380I	TGFBRAP1_uc010fjc.2_Missense_Mutation_p.V150I|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.V380I	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	380					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						AGCTCCCGGACATCAAGCTGG	0.532													T	105897164	T	T	105897164	3	4	219	1	0	0	0	0	1	0	0	0	15821	478	17	3	1472	3	TGFBRAP1	2	105897164	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	87133021	105897164	137302209	5	15295											
CNTNAP5	129684	broad.mit.edu	37	chr2	125367398	125367398	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccatctacgagcaatcctgcGaggtgtacaggcaccagggg	13	12	1	0			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr2:125367398G>A	uc002tno.2	+	12	2138	c.1774G>A	c.(1774-1776)GAG>AAG	p.E592K	CNTNAP5_uc010flu.2_Missense_Mutation_p.E593K	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	592	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCAATCCTGCGAGGTGTACAG	0.517													A	125367398	A	A	125367398	3	1	219	1	0	0	0	0	1	0	0	0	3650	1059	37	2	1820	2	CNTNAP5	2	125367398	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08	19470234	125367398	117831975	6	15296											
GALNT5	11227	broad.mit.edu	37	chr2	158114680	158114681	+	Frame_Shift_Ins	INS	-	C	C													gtcatctggctcctctttgaINScatggcagctctccgcctct							TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr2:158114680_158114681insC	uc002tzg.2	+	1	341_342	c.86_87insC	c.(85-87)GACfs	p.D29fs	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	29	Helical; Signal-anchor for type II membrane protein; (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						CTCCTCTTTGACATGGCAGCTC	0.495													C	158114681	C	C	158114680	7	5	219	1	0	1	1	0	0	0	0	0	6216	275	10	0	88	0	GALNT5	2	158114680	Frame_Shift_Ins	INS	-	TCGA-28-5220-01A-01D-1486-08	32747282	158114680	85084693	7	15297											
PDE11A	50940	broad.mit.edu	37	chr2	178936459	178936459	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	caggaaaagagagcagcggtCagcatccaccataaggcaga	12	10	1	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr2:178936459C>G	uc002ulq.2	-	1	1024	c.706G>C	c.(706-708)GAC>CAC	p.D236H	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	236	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GAGCAGCGGTCAGCATCCACC	0.493									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				G	178936459	G	G	178936459	3	3	219	1	0	0	0	0	1	0	0	0	11631	826	29	5	2175	5	PDE11A	2	178936459	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	20821779	178936459	64262914	8	15298											
SPHKAP	80309	broad.mit.edu	37	chr2	228882884	228882884	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggacaggttgacttgaacttCgttgatgcgagatgtggcac	14	7	0	4			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr2:228882884C>T	uc002vpq.2	-	7	2733	c.2686G>A	c.(2686-2688)GAA>AAA	p.E896K	SPHKAP_uc002vpp.2_Missense_Mutation_p.E896K|SPHKAP_uc010zlx.1_Missense_Mutation_p.E896K	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	896						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ACTTGAACTTCGTTGATGCGA	0.502													T	228882884	T	T	228882884	3	4	219	1	0	0	0	0	1	0	0	0	15047	893	31	2	2440	2	SPHKAP	2	228882884	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	49946425	228882884	14316489	9	15299											
CADPS	8618	broad.mit.edu	37	chr3	62636671	62636671	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcatgctctccaagttggCcatgagcaggttgacagatg	13	10	1	3			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr3:62636671C>T	uc003dll.2	-	5	1414	c.1054G>A	c.(1054-1056)GCC>ACC	p.A352T	CADPS_uc003dlm.2_Missense_Mutation_p.A352T|CADPS_uc003dln.2_Missense_Mutation_p.A352T	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	352					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TCCAAGTTGGCCATGAGCAGG	0.478													T	62636671	T	T	62636671	3	4	219	1	0	0	0	0	1	0	0	0	2570	739	26	3	3184	3	CADPS	3	62636671	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08		62636671	135385759	10	15300											
HEATR7B2	133558	broad.mit.edu	37	chr5	41070948	41070948	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tatggattcctctgtactaaGtgtcatgtcttggctgtttc	9	8	3	0			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr5:41070948G>T	uc003jmj.3	-	1	497	c.7C>A	c.(7-9)CTT>ATT	p.L3I		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	3							binding			ovary(6)|central_nervous_system(2)	8						TCTGTACTAAGTGTCATGTCT	0.398													T	41070948	T	T	41070948	3	4	219	1	0	0	0	0	1	0	0	0	7035	1029	36	5	4918	5	HEATR7B2	5	41070948	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08		41070948	139844312	11	15301											
ENC1	8507	broad.mit.edu	37	chr5	73931652	73931652	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatagcgcttcttcaggtcaTagctgatccagttaattgca	8	9	3	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr5:73931652T>C	uc003kdc.3	-	2	1790	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	ENC1_uc011css.1_Missense_Mutation_p.Y147C	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	220					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		CTTCAGGTCATAGCTGATCCA	0.512													C	73931652	C	C	73931652	3	2	219	1	0	0	0	0	1	0	0	0	5113	1406	49	4	1114	4	ENC1	5	73931652	Missense_Mutation	SNP	T	TCGA-28-5220-01A-01D-1486-08	32860704	73931652	106983608	12	15302											
PDGFRB	5159	broad.mit.edu	37	chr5	149503887	149503887	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gactcatgatcttcagctccGacataagggcttgcttctca	8	12	4	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr5:149503887G>A	uc003lro.2	-	14	2418	c.1949C>T	c.(1948-1950)TCG>TTG	p.S650L	PDGFRB_uc010jhd.2_Missense_Mutation_p.S489L	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	650	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTTCAGCTCCGACATAAGGGC	0.637			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								A	149503887	A	A	149503887	3	1	219	1	0	0	0	0	1	0	0	0	11662	1059	37	2	1411	2	PDGFRB	5	149503887	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08	75572235	149503887	31411373	13	15303											
SDK1	221935	broad.mit.edu	37	chr7	4011129	4011129	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcgtccaccctcctgaggaCcacgtggtgattaaggggac	12	12	0	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr7:4011129C>A	uc003smx.2	+	12	1885	c.1746C>A	c.(1744-1746)GAC>GAA	p.D582E		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	582	Ig-like C2-type 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CTCCTGAGGACCACGTGGTGA	0.542													A	4011129	A	A	4011129	3	1	219	1	0	0	0	0	1	0	0	0	13968	506	18	5	1792	5	SDK1	7	4011129	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08		4011129	155127534	14	15304											
AQP1	358	broad.mit.edu	37	chr7	30961834	30961834	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctctctgtagcccttggaCacctcctggctgtgagtcag	11	14	2	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr7:30961834C>T	uc003tbv.1	+	2	595	c.538C>T	c.(538-540)CAC>TAC	p.H180Y	AQP1_uc011kac.1_Missense_Mutation_p.H240Y|AQP1_uc010kwf.1_Missense_Mutation_p.H97Y|AQP1_uc010kwg.1_Missense_Mutation_p.H61Y|AQP1_uc010kwh.1_Missense_Mutation_p.H129Y	NM_198098	NP_932766	P29972	AQP1_HUMAN	aquaporin 1	180	Helical; Name=Helix 5.	Substrate discrimination.			ammonium transport|cell volume homeostasis|cellular hyperosmotic response|cellular response to cAMP|cellular response to copper ion|cellular response to dexamethasone stimulus|cellular response to hydrogen peroxide|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to mercury ion|cellular response to nitric oxide|cellular response to retinoic acid|cellular response to salt stress|cellular response to UV|cerebrospinal fluid secretion|cGMP biosynthetic process|establishment or maintenance of actin cytoskeleton polarity|lateral ventricle development|maintenance of symbiont-containing vacuole via substance secreted by host|negative regulation of apoptosis|odontogenesis|pancreatic juice secretion|positive regulation of angiogenesis|positive regulation of fibroblast proliferation|positive regulation of saliva secretion|renal water transport|response to drug|transepithelial water transport	apical plasma membrane|basal plasma membrane|brush border membrane|cytoplasm|integral to plasma membrane|nuclear membrane|sarcolemma|symbiont-containing vacuole	ammonia transmembrane transporter activity|carbon dioxide transmembrane transporter activity|glycerol transmembrane transporter activity|intracellular cGMP activated cation channel activity|nitric oxide transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|protein binding|water channel activity				0		Melanoma(862;0.16)			Acetazolamide(DB00819)	AGCCCTTGGACACCTCCTGGC	0.692													T	30961834	T	T	30961834	3	4	219	1	0	0	0	0	1	0	0	0	821	478	17	3	801	3	AQP1	7	30961834	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	26950705	30961834	128176829	15	15305											
PKD1L1	168507	broad.mit.edu	37	chr7	47840381	47840381	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaatgaaacagcagcccggGgaaggcgtctgtgaaggtgc	15	8	1	2	rs141837186		TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr7:47840381G>A	uc003tny.1	-	54	8059	c.8059C>T	c.(8059-8061)CCC>TCC	p.P2687S	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2687	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AGCAGCCCGGGGAAGGCGTCT	0.577													A	47840381	A	A	47840381	3	1	219	1	0	0	0	0	1	0	0	0	11964	1232	43	3	506	3	PKD1L1	7	47840381	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08	16878547	47840381	111298282	16	15306											
AKAP9	10142	broad.mit.edu	37	chr7	91624020	91624020	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaacaagcaagaagagaaaAggatgagacaatgagagaat	11	4	0	5			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr7:91624020A>G	uc003ulg.2	+	6	887	c.662A>G	c.(661-663)AAG>AGG	p.K221R	AKAP9_uc003uld.3_Missense_Mutation_p.K221R|AKAP9_uc003ule.2_Missense_Mutation_p.K233R|AKAP9_uc003ulf.2_Missense_Mutation_p.K221R	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	233	Potential.|Gln-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGAAGAGAAAAGGATGAGACA	0.318			T	BRAF	papillary thyroid								G	91624020	G	G	91624020	3	3	219	1	0	0	0	0	1	0	0	0	459	72	3	4	684	4	AKAP9	7	91624020	Missense_Mutation	SNP	A	TCGA-28-5220-01A-01D-1486-08	43783639	91624020	67514643	17	15307											
RELN	5649	broad.mit.edu	37	chr7	103191670	103191670	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcagaaggtgccaggtcGccccgaagtcccttgaaaat	12	12	0	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr7:103191670G>A	uc003vca.2	-	41	6306	c.6146C>T	c.(6145-6147)GCG>GTG	p.A2049V	RELN_uc010liz.2_Missense_Mutation_p.A2049V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2049	BNR 9.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GTGCCAGGTCGCCCCGAAGTC	0.547													A	103191670	A	A	103191670	3	1	219	1	0	0	0	0	1	0	0	0	13220	1087	38	1	4336	1	RELN	7	103191670	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08	11567650	103191670	55946993	18	15308											
RNF32	140545	broad.mit.edu	37	chr7	156451221	156451221	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaacctgaggaaaacagtacCtcccacagatgccaagttaa	7	11	0	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr7:156451221C>G	uc003wmo.2	+	7	823	c.641C>G	c.(640-642)CCT>CGT	p.P214R	RNF32_uc010lql.1_RNA|RNF32_uc010lqm.2_Missense_Mutation_p.P214R|RNF32_uc003wmq.2_Missense_Mutation_p.P214R|RNF32_uc003wmr.2_Missense_Mutation_p.P214R|RNF32_uc003wms.2_Missense_Mutation_p.P214R|RNF32_uc003wmu.2_RNA|RNF32_uc003wmt.2_Missense_Mutation_p.P214R	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	214	IQ.					aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		AAAACAGTACCTCCCACAGAT	0.383													G	156451221	G	G	156451221	3	3	219	1	0	0	0	0	1	0	0	0	13488	681	24	5	663	5	RNF32	7	156451221	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	53259551	156451221	2687442	19	15309											
LYN	4067	broad.mit.edu	37	chr8	56863056	56863056	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcaaagtcccttttaacaaAaaaagaaggcttcatcccca	5	11	1	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr8:56863056A>G	uc003xsk.3	+	5	605	c.323A>G	c.(322-324)AAA>AGA	p.K108R	LYN_uc003xsl.3_Missense_Mutation_p.K87R	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	108	SH3.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			CTTTTAACAAAAAAAGAAGGC	0.348													G	56863056	G	G	56863056	3	3	219	1	0	0	0	0	1	0	0	0	9107	14	1	4	337	4	LYN	8	56863056	Missense_Mutation	SNP	A	TCGA-28-5220-01A-01D-1486-08		56863056	89500966	20	15310											
TRAM1	23471	broad.mit.edu	37	chr8	71510232	71510256	+	Splice_Site	DEL	TCGCCTGTTAATTTTCTAAAAATAA	-	-													tttgttttggagaagtgcatTcgcctgttaattttctaaaa							TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr8:71510232_71510256delTCGCCTGTTAATTTTCTAAAAATAA	uc003xyo.1	-	4	480	c.310_splice	c.e4-1	p.K104_splice	TRAM1_uc011lfc.1_Splice_Site_p.K73_splice	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1						cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			AGAAGTGCATTCGCCTGTTAATTTTCTAAAAATAAAAACAGCCAT	0.302													-	71510256	-	-	71510232	8	5	219	1	0	1	0	1	0	0	1	0	16448	1770	62	0	832	0	TRAM1	8	71510232	Splice_Site	DEL	TCGCCTGTTAATTTTCTAAAAATAA	TCGA-28-5220-01A-01D-1486-08	14647176	71510232	74853790	21	15311											
COL14A1	7373	broad.mit.edu	37	chr8	121219270	121219270	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggttaactggactcatgcCccaggaaatgtggaaaaata	10	7	1	0			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr8:121219270C>T	uc003yox.2	+	10	1393	c.1128C>T	c.(1126-1128)GCC>GCT	p.A376A	COL14A1_uc003yoy.2_Silent_p.A54A|COL14A1_uc010mde.1_Silent_p.A54A	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	376	Fibronectin type-III 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGACTCATGCCCCAGGAAATG	0.428													T	121219270	T	T	121219270	2	4	219	1	0	0	0	0	0	0	0	1	3671	610	22	3		3	COL14A1	8	121219270	Silent	SNP	C	TCGA-28-5220-01A-01D-1486-08	49709038	121219270	25144752	22	15312											
FOXB2	442425	broad.mit.edu	37	chr9	79635212	79635212	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcagcagccgtctcacccCggcaagatgcaggaggcggc	13	16	2	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr9:79635212C>T	uc004ako.1	+	1	642	c.642C>T	c.(640-642)CCC>CCT	p.P214P		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	214					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CGTCTCACCCCGGCAAGATGC	0.517													T	79635212	T	T	79635212	2	4	219	1	0	0	0	0	0	0	0	1	5993	639	23	2		2	FOXB2	9	79635212	Silent	SNP	C	TCGA-28-5220-01A-01D-1486-08		79635212	61578219	23	15313											
OR13C4	138804	broad.mit.edu	37	chr9	107289309	107289309	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagagaggttgcccaggaagAagtacatgggcatgtgaaga	15	5	0	4			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr9:107289309A>G	uc011lvn.1	-	1	182	c.182T>C	c.(181-183)TTC>TCC	p.F61S		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCCCAGGAAGAAGTACATGGG	0.418													G	107289309	G	G	107289309	3	3	219	1	0	0	0	0	1	0	0	0	10936	246	9	4	776	4	OR13C4	9	107289309	Missense_Mutation	SNP	A	TCGA-28-5220-01A-01D-1486-08	27654097	107289309	33924122	24	15314											
PTCHD3	374308	broad.mit.edu	37	chr10	27702773	27702773	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaggaagatccaggggtgcGcgcccacctgccaccccagc	13	17	0	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr10:27702773G>A	uc001itu.2	-	1	525	c.407C>T	c.(406-408)GCG>GTG	p.A136V		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	136					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CCAGGGGTGCGCGCCCACCTG	0.667													A	27702773	A	A	27702773	3	1	219	1	0	0	0	0	1	0	0	0	12734	1087	38	1	1912	1	PTCHD3	10	27702773	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08		27702773	107831974	25	15315											
OR51M1	390059	broad.mit.edu	37	chr11	5410816	5410816	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cattctgatcattattaagaCcaaccctcgtctgcacacac	4	14	3	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr11:5410816C>A	uc010qzc.1	+	1	188	c.188C>A	c.(187-189)ACC>AAC	p.T63N	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	63						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTATTAAGACCAACCCTCGT	0.478													A	5410816	A	A	5410816	3	1	219	1	0	0	0	0	1	0	0	0	11103	507	18	5	190	5	OR51M1	11	5410816	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08		5410816	129595700	26	15316											
CTNND1	1500	broad.mit.edu	37	chr11	57559037	57559037	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgagaagctgacccgggcGctggaggaggaacggcgcca	17	10	0	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr11:57559037G>A	uc001nmc.3	+	3	658	c.87G>A	c.(85-87)GCG>GCA	p.A29A	CTNND1_uc001nlf.1_Silent_p.A29A|CTNND1_uc001nlh.1_Silent_p.A29A|CTNND1_uc001nlu.3_Intron|CTNND1_uc001nlt.3_Intron|CTNND1_uc001nls.3_Intron|CTNND1_uc001nlw.3_Intron|CTNND1_uc001nmf.3_Silent_p.A29A|CTNND1_uc001nmd.3_5'UTR|CTNND1_uc001nlk.3_5'UTR|CTNND1_uc001nme.3_Silent_p.A29A|CTNND1_uc001nll.3_5'UTR|CTNND1_uc001nmg.3_5'UTR|CTNND1_uc001nlj.3_5'UTR|CTNND1_uc001nlr.3_5'UTR|CTNND1_uc001nlp.3_5'UTR|CTNND1_uc001nlx.3_Intron|CTNND1_uc001nlz.3_Intron|CTNND1_uc009ymn.2_Intron|CTNND1_uc001nlm.3_Silent_p.A29A|CTNND1_uc001nly.3_Intron|CTNND1_uc001nmb.3_Intron|CTNND1_uc001nma.3_Intron|CTNND1_uc001nmi.3_Intron|CTNND1_uc001nmh.3_Silent_p.A29A|CTNND1_uc001nlq.3_Intron|CTNND1_uc001nln.3_Silent_p.A29A|CTNND1_uc001nli.3_Silent_p.A29A|CTNND1_uc001nlo.3_Intron|CTNND1_uc001nlv.3_Intron	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	29	Potential.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				TGACCCGGGCGCTGGAGGAGG	0.637													A	57559037	A	A	57559037	2	1	219	1	0	0	0	0	0	0	0	1	4019	1074	38	1		1	CTNND1	11	57559037	Silent	SNP	G	TCGA-28-5220-01A-01D-1486-08	52148221	57559037	77447479	27	15317											
ACER3	55331	broad.mit.edu	37	chr11	76701596	76701596	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttgcaggtttaccttaaggTaaaagagccgatattccatc	8	8	0	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr11:76701596T>C	uc009yum.1	+	6	520	c.416T>C	c.(415-417)GTA>GCA	p.V139A	ACER3_uc010rsg.1_Missense_Mutation_p.V97A|ACER3_uc009yul.1_RNA|ACER3_uc001oxu.2_RNA|ACER3_uc009yun.1_Missense_Mutation_p.V97A|ACER3_uc009yuo.1_Missense_Mutation_p.V44A|ACER3_uc010rsh.1_Missense_Mutation_p.V102A|ACER3_uc010rsi.1_Missense_Mutation_p.V44A|ACER3_uc010rsj.1_Missense_Mutation_p.V44A	NM_018367	NP_060837	Q9NUN7	ACER3_HUMAN	phytoceramidase, alkaline	139					ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity				0						TACCTTAAGGTAAAAGAGCCG	0.338													C	76701596	C	C	76701596	3	2	219	1	0	0	0	0	1	0	0	0	140	1638	57	4	438	4	ACER3	11	76701596	Missense_Mutation	SNP	T	TCGA-28-5220-01A-01D-1486-08	19142559	76701596	58304920	28	15318											
NNMT	4837	broad.mit.edu	37	chr11	114182998	114182998	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcctggtgatcatggatgcGctcaagagcagctactacat	10	10	2	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr11:114182998G>A	uc001por.1	+	5	858	c.594G>A	c.(592-594)GCG>GCA	p.A198A	NNMT_uc001pos.1_Silent_p.A198A	NM_006169	NP_006160	P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	198					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			ovary(1)	1		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	TCATGGATGCGCTCAAGAGCA	0.612													A	114182998	A	A	114182998	2	1	219	1	0	0	0	0	0	0	0	1	10509	1074	38	1		1	NNMT	11	114182998	Silent	SNP	G	TCGA-28-5220-01A-01D-1486-08	37481402	114182998	20823518	29	15319											
OR6X1	390260	broad.mit.edu	37	chr11	123624636	123624636	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaaggatggttgctatgacGcccaggagttccaaaatgct	11	9	0	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr11:123624636G>A	uc010rzy.1	-	1	591	c.591C>T	c.(589-591)GGC>GGT	p.G197G		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	197	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TTGCTATGACGCCCAGGAGTT	0.448													A	123624636	A	A	123624636	2	1	219	1	0	0	0	0	0	0	0	1	11212	1074	38	1		1	OR6X1	11	123624636	Silent	SNP	G	TCGA-28-5220-01A-01D-1486-08	9441638	123624636	11381880	30	15320											
NDUFA12	55967	broad.mit.edu	37	chr12	95365322	95365322	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacgttgaatttatggttcGtccaaatgaatttacgagca	8	7	1	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr12:95365322G>A	uc001tdl.2	-	4	387	c.332C>T	c.(331-333)ACG>ATG	p.T111M		NM_018838	NP_061326	Q9UI09	NDUAC_HUMAN	13kDa differentiation-associated protein	111					respiratory electron transport chain|respiratory gaseous exchange|response to oxidative stress|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	TTTATGGTTCGTCCAAATGAA	0.423													A	95365322	A	A	95365322	3	1	219	1	0	0	0	0	1	0	0	0	10262	1145	40	1	109	1	NDUFA12	12	95365322	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08		95365322	38486573	31	15321											
RBM19	9904	broad.mit.edu	37	chr12	114282577	114282577	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaagtgggtgctgtgacacAgggcgttgaaggctctctgc	15	9	1	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr12:114282577A>G	uc009zwi.2	-	23	2825	c.2681T>C	c.(2680-2682)CTG>CCG	p.L894P	RBM19_uc001tvn.3_Missense_Mutation_p.L894P|RBM19_uc001tvm.2_Missense_Mutation_p.L894P	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	894	RRM 6.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GCTGTGACACAGGGCGTTGAA	0.637													G	114282577	G	G	114282577	3	3	219	1	0	0	0	0	1	0	0	0	13121	188	7	4	209	4	RBM19	12	114282577	Missense_Mutation	SNP	A	TCGA-28-5220-01A-01D-1486-08	18917255	114282577	19569318	32	15322											
RABGGTA	5875	broad.mit.edu	37	chr14	24739285	24739285	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ataagacttggggttcacccGcaggcagctctccaggaagc	12	12	2	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr14:24739285G>A	uc001wof.2	-	4	723	c.301C>T	c.(301-303)CGG>TGG	p.R101W	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Missense_Mutation_p.R101W|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	101	PFTA 2.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		GGGTTCACCCGCAGGCAGCTC	0.632													A	24739285	A	A	24739285	3	1	219	1	0	0	0	0	1	0	0	0	12967	1086	38	1	1454	1	RABGGTA	14	24739285	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08		24739285	82610255	33	15323											
CORO7	79585	broad.mit.edu	37	chr16	4414382	4414382	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagtgaagctcgggtggggCcggcaggcggggttgaggct	22	7	0	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr16:4414382C>T	uc002cwh.3	-	14	1290	c.1170G>A	c.(1168-1170)CGG>CGA	p.R390R	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Silent_p.R390R|CORO7_uc002cwg.3_Silent_p.R170R|CORO7_uc010uxh.1_Silent_p.R372R|CORO7_uc010uxi.1_Silent_p.R305R|CORO7_uc002cwi.1_Silent_p.R170R|CORO7_uc010uxj.1_RNA|CORO7_uc010btp.1_Silent_p.R170R	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	390						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						TCGGGTGGGGCCGGCAGGCGG	0.701													T	4414382	T	T	4414382	2	4	219	1	0	0	0	0	0	0	0	1	3759	726	26	3		3	CORO7	16	4414382	Silent	SNP	C	TCGA-28-5220-01A-01D-1486-08		4414382	85940371	34	15324											
AMAC1	146861	broad.mit.edu	37	chr17	33520922	33520922	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gagcagacggtggaagaaccTttgcgaacagtggcagcgtt	15	8	0	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr17:33520922T>A	uc002hjd.2	-	1	491	c.405A>T	c.(403-405)AAA>AAT	p.K135N		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	135	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		TGGAAGAACCTTTGCGAACAG	0.607													A	33520922	A	A	33520922	3	1	219	1	0	0	0	0	1	0	0	0	559	1606	56	5	615	5	AMAC1	17	33520922	Missense_Mutation	SNP	T	TCGA-28-5220-01A-01D-1486-08		33520922	47674288	35	15325											
KRT20	54474	broad.mit.edu	37	chr17	39041346	39041346	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccataaacgctgggtgtcGtcccgaggcgctgcatgccc	12	16	0	0			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr17:39041346G>A	uc002hvl.2	-	1	134	c.92C>T	c.(91-93)ACG>ATG	p.T31M		NM_019010	NP_061883	P35900	K1C20_HUMAN	keratin 20	31	Head.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			large_intestine(1)|kidney(1)|skin(1)	3		Breast(137;0.000301)|Ovarian(249;0.15)				GCTGGGTGTCGTCCCGAGGCG	0.607													A	39041346	A	A	39041346	3	1	219	1	0	0	0	0	1	0	0	0	8458	1145	40	1	1214	1	KRT20	17	39041346	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08	5520424	39041346	42153864	36	15326											
TBKBP1	9755	broad.mit.edu	37	chr17	45776024	45776024	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agcagcagctgcggcaacagCaaggcctccaggatgcagcc	13	14	0	0			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr17:45776024C>G	uc002ilu.2	+	4	1366	c.517C>G	c.(517-519)CAA>GAA	p.Q173E		NM_014726	NP_055541	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	173					innate immune response						0						GCGGCAACAGCAAGGCCTCCA	0.647											OREG0024498	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	45776024	G	G	45776024	3	3	219	1	0	0	0	0	1	0	0	0	15635	711	25	5	531	5	TBKBP1	17	45776024	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	6734678	45776024	35419186	37	15327											
EXOC7	23265	broad.mit.edu	37	chr17	74084564	74084564	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttgatgttgtctgcgaagTcctccagcgctttggcaccg	11	13	1	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr17:74084564T>G	uc002jqs.2	-	11	1528	c.1433A>C	c.(1432-1434)GAC>GCC	p.D478A	EXOC7_uc010dgv.1_Missense_Mutation_p.D374A|EXOC7_uc002jqq.2_Missense_Mutation_p.D427A|EXOC7_uc010wsw.1_Missense_Mutation_p.D450A|EXOC7_uc010wsx.1_Missense_Mutation_p.D419A|EXOC7_uc002jqr.2_Missense_Mutation_p.D396A|EXOC7_uc010wsv.1_Missense_Mutation_p.D386A	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	478					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			GTCTGCGAAGTCCTCCAGCGC	0.632													G	74084564	G	G	74084564	3	3	219	1	0	0	0	0	1	0	0	0	5310	1667	58	5	814	5	EXOC7	17	74084564	Missense_Mutation	SNP	T	TCGA-28-5220-01A-01D-1486-08	28308540	74084564	7110646	38	15328											
ZNF407	55628	broad.mit.edu	37	chr18	72775660	72775660	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctggatgcattgctctgtGcggtcactgaattaggggag	14	9	2	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr18:72775660G>A	uc002llw.2	+	8	6040	c.5983G>A	c.(5983-5985)GCG>ACG	p.A1995T		NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1995					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ATTGCTCTGTGCGGTCACTGA	0.627													A	72775660	A	A	72775660	3	1	219	1	0	0	0	0	1	0	0	0	17884	1319	46	3	6143	3	ZNF407	18	72775660	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08		72775660	5301588	39	15329											
FBN3	84467	broad.mit.edu	37	chr19	8176555	8176555	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcagaagaagccatccccgGcaaagccctggcggcaggtg	14	14	0	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr19:8176555G>A	uc002mjf.2	-	31	4082	c.4061C>T	c.(4060-4062)GCC>GTC	p.A1354V		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1354	EGF-like 20; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GCCATCCCCGGCAAAGCCCTG	0.637													A	8176555	A	A	8176555	3	1	219	1	0	0	0	0	1	0	0	0	5704	1203	42	3	4500	3	FBN3	19	8176555	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08		8176555	50952428	40	15330											
ZNF101	94039	broad.mit.edu	37	chr19	19790246	19790247	+	Frame_Shift_Ins	INS	-	C	C													gaaacaacatgggaaagcctINSccatttcccccagtagtggt							TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr19:19790246_19790247insC	uc002nni.1	+	4	558_559	c.448_449insC	c.(448-450)TCCfs	p.S150fs	ZNF101_uc010ecg.1_Frame_Shift_Ins_p.S30fs|ZNF101_uc002nnj.1_Frame_Shift_Ins_p.S30fs	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGGGAAAGCCTCCATTTCCCCC	0.51													C	19790247	C	C	19790246	7	5	219	1	0	1	1	0	0	0	0	0	17711	1551	54	0	462	0	ZNF101	19	19790246	Frame_Shift_Ins	INS	-	TCGA-28-5220-01A-01D-1486-08	11613691	19790246	39338737	41	15331											
CCDC155	147872	broad.mit.edu	37	chr19	49910497	49910497	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accggctcctttcttggcagCggcagctctttgagtgtgaa	12	11	2	2			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr19:49910497C>T	uc002pnm.1	+	11	1051	c.877C>T	c.(877-879)CGG>TGG	p.R293W	CCDC155_uc010emx.1_Missense_Mutation_p.R266W	NM_144688	NP_653289	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	293	Potential.					integral to membrane	calcium ion binding			ovary(1)|central_nervous_system(1)	2						TTCTTGGCAGCGGCAGCTCTT	0.592													T	49910497	T	T	49910497	3	4	219	1	0	0	0	0	1	0	0	0	2788	782	27	1	915	1	CCDC155	19	49910497	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	30120251	49910497	9218486	42	15332											
TBC1D17	79735	broad.mit.edu	37	chr19	50387771	50387771	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcctctacgtcattcagaaCgaggtggatgctttctggtg	11	9	4	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr19:50387771C>T	uc002pqo.2	+	12	1451	c.1299C>T	c.(1297-1299)AAC>AAT	p.N433N	TBC1D17_uc010ybg.1_Silent_p.N400N|TBC1D17_uc002pqp.2_Silent_p.N84N|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Silent_p.N84N|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	433	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		TCATTCAGAACGAGGTGGATG	0.607													T	50387771	T	T	50387771	2	4	219	1	0	0	0	0	0	0	0	1	15603	535	19	1		1	TBC1D17	19	50387771	Silent	SNP	C	TCGA-28-5220-01A-01D-1486-08	477274	50387771	8741212	43	15333											
TGM2	7052	broad.mit.edu	37	chr20	36789862	36789862	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agactgtctacactggcctcGtagttgcggccctcaaagtg	11	12	2	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr20:36789862G>A	uc002xhr.2	-	2	250	c.150C>T	c.(148-150)TAC>TAT	p.Y50Y	TGM2_uc010zvx.1_Silent_p.Y50Y|TGM2_uc010zvy.1_Intron|TGM2_uc002xhs.1_Silent_p.Y50Y|TGM2_uc002xht.2_Silent_p.Y50Y|TGM2_uc002xhu.3_Silent_p.Y50Y	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	50					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	CACTGGCCTCGTAGTTGCGGC	0.557													A	36789862	A	A	36789862	2	1	219	1	0	0	0	0	0	0	0	1	15827	1140	40	1		1	TGM2	20	36789862	Silent	SNP	G	TCGA-28-5220-01A-01D-1486-08		36789862	26235658	44	15334											
PFDN4	5203	broad.mit.edu	37	chr20	52830966	52830966	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggaatacaagtagaatcaCagagctgaaggaagaaatag	11	5	1	4			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr20:52830966C>T	uc002xwx.2	+	2	239	c.101C>T	c.(100-102)ACA>ATA	p.T34I		NM_002623	NP_002614	Q9NQP4	PFD4_HUMAN	prefoldin subunit 4	34					'de novo' posttranslational protein folding	prefoldin complex	chaperone binding|unfolded protein binding				0	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		Colorectal(105;0.124)|STAD - Stomach adenocarcinoma(23;0.206)			AGTAGAATCACAGAGCTGAAG	0.284													T	52830966	T	T	52830966	3	4	219	1	0	0	0	0	1	0	0	0	11757	478	17	3	107	3	PFDN4	20	52830966	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	16041104	52830966	10194554	45	15335											
TRPM2	7226	broad.mit.edu	37	chr21	45786659	45786659	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgtccgagtctcccaggacaCgccctccagcgtgatctacc	9	18	2	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr21:45786659C>G	uc002zet.1	+	5	659	c.446C>G	c.(445-447)ACG>AGG	p.T149R	TRPM2_uc002zeu.1_Missense_Mutation_p.T149R|TRPM2_uc002zew.1_Missense_Mutation_p.T149R|TRPM2_uc010gpt.1_Missense_Mutation_p.T149R|TRPM2_uc002zex.1_5'Flank	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	149	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCCCAGGACACGCCCTCCAGC	0.617													G	45786659	G	G	45786659	3	3	219	1	0	0	0	0	1	0	0	0	16583	536	19	5	460	5	TRPM2	21	45786659	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08		45786659	2343236	46	15336											
PICK1	9463	broad.mit.edu	37	chr22	38471061	38471061	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggaggaggaggaagacacGgcagctggggagccgtccag	20	8	0	1			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr22:38471061G>A	uc003auq.2	+	13	1560	c.1170G>A	c.(1168-1170)ACG>ACA	p.T390T	PICK1_uc003aur.2_Silent_p.T390T|PICK1_uc003aus.2_Silent_p.T390T|PICK1_uc003aut.2_Silent_p.T390T	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	390					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					aggaagaCACGGCAGCTGGGG	0.567													A	38471061	A	A	38471061	2	1	219	1	0	0	0	0	0	0	0	1	11881	1103	39	2		2	PICK1	22	38471061	Silent	SNP	G	TCGA-28-5220-01A-01D-1486-08		38471061	12833505	47	15337											
RIBC2	26150	broad.mit.edu	37	chr22	45813805	45813805	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagggaatggaagaacgccCgtgctgaacaaaaatgcgca	12	8	0	2	rs137932273		TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chr22:45813805C>T	uc011aqs.1	+	4	729	c.520C>T	c.(520-522)CGT>TGT	p.R174C		NM_015653	NP_056468	Q9H4K1	RIBC2_HUMAN	RIB43A domain with coiled-coils 2	106											0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		GAAGAACGCCCGTGCTGAACA	0.418													T	45813805	T	T	45813805	3	4	219	1	0	0	0	0	1	0	0	0	13353	652	23	2	529	2	RIBC2	22	45813805	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	7342744	45813805	5490761	48	15338											
SMC1A	8243	broad.mit.edu	37	chrX	53432322	53432322	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggttccatccagtgccactGtctacacacagcagggggaa	12	12	1	0			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chrX:53432322G>T	uc004dsg.2	-	12	1982	c.1913C>A	c.(1912-1914)ACA>AAA	p.T638K	SMC1A_uc011moe.1_Missense_Mutation_p.T616K|SMC1A_uc011mof.1_Missense_Mutation_p.T404K	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	638	Flexible hinge.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CAGTGCCACTGTCTACACACA	0.562													T	53432322	T	T	53432322	3	4	219	1	0	0	0	0	1	0	0	0	14781	1391	48	5	1844	5	SMC1A	23	53432322	Missense_Mutation	SNP	G	TCGA-28-5220-01A-01D-1486-08		53432322	101838238	49	15339											
SATL1	340562	broad.mit.edu	37	chrX	84347411	84347411	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cctctttcattcttcccatgCcatgtccaggagttcttctc	5	15	5	0			TCGA-28-5220-01A-01D-1486-08	TCGA-28-5220-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f7b80486-fa19-49c7-8ace-ea61338677d7	b433f374-fb46-4a11-9ab2-438803d8ac1f	g.chrX:84347411C>G	uc011mqx.1	-	6	2074	c.2074G>C	c.(2074-2076)GCA>CCA	p.A692P	SATL1_uc004een.2_3'UTR	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	505	N-acetyltransferase.						N-acetyltransferase activity			breast(2)	2						TCTTCCCATGCCATGTCCAGG	0.458													G	84347411	G	G	84347411	3	3	219	1	0	0	0	0	1	0	0	0	13855	754	26	5		5	SATL1	23	84347411	Missense_Mutation	SNP	C	TCGA-28-5220-01A-01D-1486-08	30915089	84347411	70923149	50	15340											
DNAJC11	55735	broad.mit.edu	37	chr1	6705885	6705885	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagtggctggttttagtgtcTcggacgatgctagtgttcat	13	6	2	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:6705885T>C	uc001aof.2	-	8	964	c.858A>G	c.(856-858)CGA>CGG	p.R286R	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.R286R|DNAJC11_uc010nzu.1_Silent_p.R196R	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	286					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TTTTAGTGTCTCGGACGATGC	0.587													C	6705885	C	C	6705885	2	2	220	1	0	0	0	0	0	0	0	1	4630	1538	54	4		4	DNAJC11	1	6705885	Silent	SNP	T	TCGA-28-6450-01A-11D-1696-08		6705885	242544736	1	15341											
NPPA	4878	broad.mit.edu	37	chr1	11907662	11907662	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tggacacggcattgtacatgGgattagctctggtctgacct	12	9	2	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:11907662G>C	uc001ati.2	-	1	179	c.80C>G	c.(79-81)CCC>CGC	p.P27R	CLCN6_uc010oav.1_RNA|CLCN6_uc010oaw.1_RNA|CLCN6_uc010oax.1_RNA|CLCN6_uc010oay.1_RNA|CLCN6_uc010oaz.1_RNA|CLCN6_uc010oba.1_RNA	NM_006172	NP_006163	P01160	ANF_HUMAN	natriuretic peptide precursor A preproprotein	27					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATTGTACATGGGATTAGCTCT	0.567													C	11907662	C	C	11907662	3	2	220	1	0	0	0	0	1	0	0	0	10591	1232	43	5	387	5	NPPA	1	11907662	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	5201777	11907662	237342959	2	15342											
NPPA	4878	broad.mit.edu	37	chr1	11907712	11907712	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aatgccagtaaaaggaggaaGctcacggtggtggtggagaa	16	5	1	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:11907712G>C	uc001ati.2	-	1	129	c.30C>G	c.(28-30)AGC>AGG	p.S10R		NM_006172	NP_006163	P01160	ANF_HUMAN	natriuretic peptide precursor A preproprotein	10					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAAGGAGGAAGCTCACGGTGG	0.473													C	11907712	C	C	11907712	3	2	220	1	0	0	0	0	1	0	0	0	10591	962	34	5	437	5	NPPA	1	11907712	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	50	11907712	237342909	3	15343											
ADC	113451	broad.mit.edu	37	chr1	33583641	33583641	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tctttgacaacatgggcgccTacactgtgggcatgggttcc	12	11	1	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:33583641T>A	uc001bwr.2	+	11	1755	c.1168T>A	c.(1168-1170)TAC>AAC	p.Y390N	ADC_uc001bws.2_Missense_Mutation_p.Y390N|ADC_uc009vue.2_Missense_Mutation_p.Y390N|ADC_uc001bwt.1_Missense_Mutation_p.Y295N|ADC_uc001bwu.2_Missense_Mutation_p.Y295N|ADC_uc001bwv.2_Missense_Mutation_p.Y295N|ADC_uc001bww.2_Missense_Mutation_p.Y295N|ADC_uc001bwx.1_Missense_Mutation_p.Y367N|ADC_uc009vug.2_Missense_Mutation_p.Y410N	NM_052998	NP_443724	Q96A70	ADC_HUMAN	ODC antizyme inhibitor-2	390					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CATGGGCGCCTACACTGTGGG	0.632													A	33583641	A	A	33583641	3	1	220	1	0	0	0	0	1	0	0	0	287	1522	53	5	1198	5	ADC	1	33583641	Missense_Mutation	SNP	T	TCGA-28-6450-01A-11D-1696-08	21675929	33583641	215666980	4	15344											
FLG	2312	broad.mit.edu	37	chr1	152285965	152285965	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcacctggtagagggaagacCctgaacgtccagaccgttcc	11	13	1	4			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:152285965C>A	uc001ezu.1	-	3	1433	c.1397G>T	c.(1396-1398)GGG>GTG	p.G466V	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	466	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGGAAGACCCTGAACGTCC	0.607									Ichthyosis				A	152285965	A	A	152285965	3	1	220	1	0	0	0	0	1	0	0	0	5922	623	22	5	10792	5	FLG	1	152285965	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	118702324	152285965	96964656	5	15345											
AQP10	89872	broad.mit.edu	37	chr1	154293715	154293715	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cggcagtgcctggcagagttTctgggtgtgtttgtactcat	14	8	2	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:154293715T>C	uc001feu.2	+	1	124	c.84T>C	c.(82-84)TTT>TTC	p.F28F	AQP10_uc001fev.2_Silent_p.F28F	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	28	Helical; (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGGCAGAGTTTCTGGGTGTGT	0.552													C	154293715	C	C	154293715	2	2	220	1	0	0	0	0	0	0	0	1	822	1780	62	4		4	AQP10	1	154293715	Silent	SNP	T	TCGA-28-6450-01A-11D-1696-08	2007750	154293715	94956906	6	15346											
EFNA3	1944	broad.mit.edu	37	chr1	155058900	155058900	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtccacagaagactttgagGgagagaaccctcaggtgccc	12	11	1	4			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:155058900G>A	uc001fhf.2	+	5	668	c.598G>A	c.(598-600)GGA>AGA	p.G200R	EFNA3_uc010pew.1_Missense_Mutation_p.G195R|EFNA3_uc010pex.1_Missense_Mutation_p.G174R|EFNA3_uc001fhg.2_Missense_Mutation_p.G177R	NM_004952	NP_004943	P52797	EFNA3_HUMAN	ephrin A3 precursor	200					cell-cell signaling	anchored to membrane|integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity				0	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		all cancers(21;5.67e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000284)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGACTTTGAGGGAGAGAACCC	0.632											OREG0013850	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	155058900	A	A	155058900	3	1	220	1	0	0	0	0	1	0	0	0	4952	1233	43	3	616	3	EFNA3	1	155058900	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	765185	155058900	94191721	7	15347											
AIM2	9447	broad.mit.edu	37	chr1	159043117	159043117	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttcatcactgcagacaccGccccagcattttgaatcatc	5	15	4	2	rs149324922		TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:159043117G>A	uc001ftj.1	-	2	418	c.173C>T	c.(172-174)GCG>GTG	p.A58V		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	58	DAPIN.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					TGCAGACACCGCCCCAGCATT	0.393													A	159043117	A	A	159043117	3	1	220	1	0	0	0	0	1	0	0	0	432	1087	38	1	878	1	AIM2	1	159043117	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	3984217	159043117	90207504	8	15348											
C1orf14	81626	broad.mit.edu	37	chr1	182908331	182908331	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cggaggcgtaaatcttcccaCattttcagtaatccacagag	8	11	2	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:182908331C>G	uc001gpu.2	-	5	1341	c.1056G>C	c.(1054-1056)ATG>ATC	p.M352I	C1orf14_uc001gpv.2_Missense_Mutation_p.M233I|C1orf14_uc010pnz.1_Missense_Mutation_p.M210I|C1orf14_uc001gpw.2_Missense_Mutation_p.M72I	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	424											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		AATCTTCCCACATTTTCAGTA	0.338													G	182908331	G	G	182908331	3	3	220	1	0	0	0	0	1	0	0	0	2000	478	17	5	929	5	C1orf14	1	182908331	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	23865214	182908331	66342290	9	15349											
TLR5	7100	broad.mit.edu	37	chr1	223285929	223285929	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atttttggatagatccaagcGagttaaagcctttaaatttc	7	6	0	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr1:223285929G>A	uc001hnv.1	-	4	891	c.445C>T	c.(445-447)CGC>TGC	p.R149C	TLR5_uc001hnw.1_Missense_Mutation_p.R149C	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	149	LRR 3.|Extracellular (Potential).				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		AGATCCAAGCGAGTTAAAGCC	0.368													A	223285929	A	A	223285929	3	1	220	1	0	0	0	0	1	0	0	0	15951	1058	37	2	2135	2	TLR5	1	223285929	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	40377598	223285929	25964692	10	15350											
DHX57	90957	broad.mit.edu	37	chr2	39088222	39088222	+	Frame_Shift_Del	DEL	A	-	-													attatttattctggtcctagAgggtactggcagaaagttca							TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr2:39088222delA	uc002rrf.2	-	5	1429	c.1330delT	c.(1330-1332)TCTfs	p.S444fs	DHX57_uc002rre.2_5'UTR|DHX57_uc002rrg.2_Frame_Shift_Del_p.S444fs	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	444							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				CTGGTCCTAGAGGGTACTGGC	0.378													-	39088222	-	-	39088222	7	5	220	1	0	1	0	1	0	0	0	0	4513	304	11	0	2910	0	DHX57	2	39088222	Frame_Shift_Del	DEL	A	TCGA-28-6450-01A-11D-1696-08		39088222	204111151	11	15351											
SEMA4F	10505	broad.mit.edu	37	chr2	74902997	74902997	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtctgtgcctggagcttccGgctggatgagtgtgtggccc	16	10	1	1	rs146294784		TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr2:74902997G>A	uc002sna.1	+	12	1715	c.1604G>A	c.(1603-1605)CGG>CAG	p.R535Q	SEMA4F_uc010ffq.1_Missense_Mutation_p.R502Q|SEMA4F_uc010ffr.1_Missense_Mutation_p.R147Q|SEMA4F_uc002snb.1_Missense_Mutation_p.R147Q|SEMA4F_uc002snc.1_Missense_Mutation_p.R380Q	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	535	PSI.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TGGAGCTTCCGGCTGGATGAG	0.587													A	74902997	A	A	74902997	3	1	220	1	0	0	0	0	1	0	0	0	14035	1116	39	2	1650	2	SEMA4F	2	74902997	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	35814775	74902997	168296376	12	15352											
KYNU	8942	broad.mit.edu	37	chr2	143713833	143713833	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctagaagccaaagccttccCttctgatcatgtaaggactt	7	11	3	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr2:143713833C>A	uc002tvl.2	+	6	627	c.497C>A	c.(496-498)CCT>CAT	p.P166H	KYNU_uc002tvk.2_Missense_Mutation_p.P166H|KYNU_uc010fnm.2_Missense_Mutation_p.P166H	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	166	Pyridoxal phosphate binding.				anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	AAAGCCTTCCCTTCTGATCAT	0.343													A	143713833	A	A	143713833	3	1	220	1	0	0	0	0	1	0	0	0	8587	681	24	5	515	5	KYNU	2	143713833	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	68810836	143713833	99485540	13	15353											
SPC25	57405	broad.mit.edu	37	chr2	169728042	169728042	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttgaaattctgctaggccctCaagatgaggggcactatctg	11	9	3	3	rs146133605	byFrequency	TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr2:169728042C>T	uc002uel.2	-	7	705	c.574G>A	c.(574-576)GAG>AAG	p.E192K		NM_020675	NP_065726	Q9HBM1	SPC25_HUMAN	spindle pole body component 25	192	Interaction with the C-terminus of SPBC24.				cell division|chromosome segregation|mitotic prometaphase|mitotic spindle organization	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			central_nervous_system(1)	1						GCTAGGCCCTCAAGATGAGGG	0.338													T	169728042	T	T	169728042	3	4	220	1	0	0	0	0	1	0	0	0	15021	835	29	3	104	3	SPC25	2	169728042	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	26014209	169728042	73471331	14	15354											
LRP2	4036	broad.mit.edu	37	chr2	170050292	170050292	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acactggtgccttttatcctCgtcactcatatccccacagt	5	15	2	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr2:170050292C>T	uc002ues.2	-	47	9022	c.8809G>A	c.(8809-8811)GAG>AAG	p.E2937K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2937	LDL-receptor class A 21.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTTTTATCCTCGTCACTCATA	0.473													T	170050292	T	T	170050292	3	4	220	1	0	0	0	0	1	0	0	0	8956	893	31	2	5290	2	LRP2	2	170050292	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	322250	170050292	73149081	15	15355											
GPD1L	23171	broad.mit.edu	37	chr3	32180198	32180198	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggagagtgcccaagaaagcGctgggaatcaccctcatcaa	12	11	3	2	rs149167213		TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr3:32180198G>A	uc003cew.2	+	3	405	c.345G>A	c.(343-345)GCG>GCA	p.A115A		NM_015141	NP_055956	Q8N335	GPD1L_HUMAN	glycerol-3-phosphate dehydrogenase 1-like	115					glycerol-3-phosphate catabolic process	glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|NAD binding|protein homodimerization activity				0						CCAAGAAAGCGCTGGGAATCA	0.502													A	32180198	A	A	32180198	2	1	220	1	0	0	0	0	0	0	0	1	6605	1074	38	1		1	GPD1L	3	32180198	Silent	SNP	G	TCGA-28-6450-01A-11D-1696-08		32180198	165842232	16	15356											
RUVBL1	8607	broad.mit.edu	37	chr3	127806571	127806571	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtttcatttcctgtggagtaTacagcatggtccggattatc	10	8	1	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr3:127806571T>C	uc003ekh.2	-	9	1201	c.1097A>G	c.(1096-1098)TAT>TGT	p.Y366C	RUVBL1_uc003eke.2_Intron|RUVBL1_uc003ekf.2_Missense_Mutation_p.Y306C|RUVBL1_uc010hss.2_Missense_Mutation_p.Y366C	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	366					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		CTGTGGAGTATACAGCATGGT	0.453													C	127806571	C	C	127806571	3	2	220	1	0	0	0	0	1	0	0	0	13752	1406	49	4	285	4	RUVBL1	3	127806571	Missense_Mutation	SNP	T	TCGA-28-6450-01A-11D-1696-08	95626373	127806571	70215859	17	15357											
PIK3CA	5290	broad.mit.edu	37	chr3	178936094	178936094	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctctctctgaaatcactgagCaggagaaagattttctatgg	9	8	4	4	rs121913286		TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr3:178936094C>A	uc003fjk.2	+	10	1793	c.1636C>A	c.(1636-1638)CAG>AAG	p.Q546K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	546	PI3K helical.		Q -> K (in cancer).|Q -> P (in cancer).|Q -> E (in cancer).|Q -> R (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.Q546K(54)|p.Q546R(17)|p.Q546P(10)|p.Q546E(9)|p.Q546L(6)|p.Q546H(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATCACTGAGCAGGAGAAAGA	0.358		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178936094	A	A	178936094	3	1	220	1	0	0	0	0	1	0	0	0	11913	711	25	5	1670	5	PIK3CA	3	178936094	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	51129523	178936094	19086336	18	15358											
MFSD10	10227	broad.mit.edu	37	chr4	2934851	2934851	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accaggcacagcagcatcacCgggcgcctccccaagcagtc	10	18	1	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr4:2934851C>T	uc003gfw.2	-	3	668	c.354G>A	c.(352-354)CCG>CCA	p.P118P	MFSD10_uc003gfv.2_5'Flank|MFSD10_uc003gfx.2_5'UTR|MFSD10_uc003gfz.2_Silent_p.P118P|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Silent_p.P118P|MFSD10_uc003ggb.1_Silent_p.P118P|MFSD10_uc003ggc.2_Silent_p.P118P|C4orf10_uc003ggd.1_5'Flank|C4orf10_uc003gge.1_5'Flank|C4orf10_uc003ggg.1_5'Flank|C4orf10_uc003ggh.2_5'Flank	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	118	Helical; (Potential).				apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GCAGCATCACCGGGCGCCTCC	0.627													T	2934851	T	T	2934851	2	4	220	1	0	0	0	0	0	0	0	1	9528	639	23	2		2	MFSD10	4	2934851	Silent	SNP	C	TCGA-28-6450-01A-11D-1696-08		2934851	188219425	19	15359											
UGT2A3	79799	broad.mit.edu	37	chr4	69798434	69798434	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgaccccagagaaaacaccAcaataccatcttcccctgaa	5	15	1	3			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr4:69798434A>G	uc003hef.2	-	3	939	c.908T>C	c.(907-909)GTG>GCG	p.V303A	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	303	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						AGAAAACACCACAATACCATC	0.363													G	69798434	G	G	69798434	3	3	220	1	0	0	0	0	1	0	0	0	16952	159	6	4	691	4	UGT2A3	4	69798434	Missense_Mutation	SNP	A	TCGA-28-6450-01A-11D-1696-08	66863583	69798434	121355842	20	15360											
PRKG2	5593	broad.mit.edu	37	chr4	82125748	82125748	+	Frame_Shift_Del	DEL	C	-	-													ggaaatttcttacctggagtCttttctgactcttgctttct							TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr4:82125748delC	uc003hmh.2	-	1	468	c.454delG	c.(454-456)GACfs	p.D152fs	PRKG2_uc011cch.1_Frame_Shift_Del_p.D152fs	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	152					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						TACCTGGAGTCTTTTCTGACT	0.428													-	82125748	-	-	82125748	7	5	220	1	0	1	0	1	0	0	0	0	12523	913	32	0	1906	0	PRKG2	4	82125748	Frame_Shift_Del	DEL	C	TCGA-28-6450-01A-11D-1696-08	12327314	82125748	109028528	21	15361											
FGG	2266	broad.mit.edu	37	chr4	155527975	155527975	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcattgtcccaggtactgaaCtgcatgccattatgggatgt	10	9	1	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr4:155527975C>A	uc003ioj.2	-	8	1152	c.1011G>T	c.(1009-1011)CAG>CAT	p.Q337H	FGG_uc003iog.2_Missense_Mutation_p.Q337H|FGG_uc003ioh.2_Missense_Mutation_p.Q345H|FGG_uc010ipx.2_Missense_Mutation_p.Q165H|FGG_uc010ipy.2_Missense_Mutation_p.Q48H|FGG_uc003ioi.2_Missense_Mutation_p.Q48H|FGG_uc003iok.2_Missense_Mutation_p.Q345H	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	337	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AGGTACTGAACTGCATGCCAT	0.473													A	155527975	A	A	155527975	3	1	220	1	0	0	0	0	1	0	0	0	5870	564	20	5	377	5	FGG	4	155527975	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	73402227	155527975	35626301	22	15362											
FBXO8	26269	broad.mit.edu	37	chr4	175160248	175160248	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tactctccacgctcttcaggGgcatggatatgacgaaaaaa	9	10	3	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr4:175160248G>C	uc003itp.2	-	5	1519	c.669C>G	c.(667-669)GCC>GCG	p.A223A	FBXO8_uc003itq.2_Silent_p.A182A	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	223	SEC7.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		GCTCTTCAGGGGCATGGATAT	0.398													C	175160248	C	C	175160248	2	2	220	1	0	0	0	0	0	0	0	1	5761	1219	43	5		5	FBXO8	4	175160248	Silent	SNP	G	TCGA-28-6450-01A-11D-1696-08	19632273	175160248	15994028	23	15363											
PLEKHG4B	153478	broad.mit.edu	37	chr5	161999	161999	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgagcgccgtggtcagccaGgctgagtgcagggagggaga	19	9	1	3			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr5:161999G>T	uc003jak.2	+	10	1571	c.1521G>T	c.(1519-1521)CAG>CAT	p.Q507H		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	507					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		TGGTCAGCCAGGCTGAGTGCA	0.627													T	161999	T	T	161999	3	4	220	1	0	0	0	0	1	0	0	0	12072	991	35	5	1559	5	PLEKHG4B	5	161999	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08		161999	180753261	24	15364											
HCN1	348980	broad.mit.edu	37	chr5	45262526	45262526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgagtgacagctgggaggCggtgggggaggcatagtgga	21	5	0	2	rs141383188	byFrequency	TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr5:45262526C>T	uc003jok.2	-	8	2195	c.2170G>A	c.(2170-2172)GCC>ACC	p.A724T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	724	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AGCTGGGAGGCGGTGGGGGAG	0.443													T	45262526	T	T	45262526	3	4	220	1	0	0	0	0	1	0	0	0	6996	768	27	1	506	1	HCN1	5	45262526	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	45100527	45262526	135652734	25	15365											
PCDHA7	56141	broad.mit.edu	37	chr5	140214002	140214002	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggatacgacccagggggcCgacatctactgctgtttatt	11	10	1	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr5:140214002C>T	uc003lhq.2	+	1	34	c.34C>T	c.(34-36)CGA>TGA	p.R12*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Nonsense_Mutation_p.R12*	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	12					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCAGGGGGCCGACATCTACT	0.468													T	140214002	T	T	140214002	4	4	220	1	0	0	0	0	0	1	0	0	11529	644	23	2	36	2	PCDHA7	5	140214002	Nonsense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	94951476	140214002	40701258	26	15366											
PCDHGB3	56102	broad.mit.edu	37	chr5	140751755	140751755	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggcggtggacgcagactcGggatacaacgcctggctgtc	16	11	0	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr5:140751755G>A	uc003ljw.1	+	1	1794	c.1794G>A	c.(1792-1794)TCG>TCA	p.S598S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Silent_p.S598S|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	598	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCAGACTCGGGATACAACG	0.672													A	140751755	A	A	140751755	2	1	220	1	0	0	0	0	0	0	0	1	11564	1103	39	2		2	PCDHGB3	5	140751755	Silent	SNP	G	TCGA-28-6450-01A-11D-1696-08	537753	140751755	40163505	27	15367											
DRD1	1812	broad.mit.edu	37	chr5	174869045	174869045	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctctatggcattattcgtcGcagggcaaagtctgtagcat	10	9	2	0	rs144813919	byFrequency	TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr5:174869045G>A	uc003mcz.2	-	2	2003	c.1058C>T	c.(1057-1059)GCG>GTG	p.A353V		NM_000794	NP_000785	P21728	DRD1_HUMAN	dopamine receptor D1	353	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			ovary(2)|skin(1)	3	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	ATTATTCGTCGCAGGGCAAAG	0.478													A	174869045	A	A	174869045	3	1	220	1	0	0	0	0	1	0	0	0	4756	1087	38	1	286	1	DRD1	5	174869045	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	34117290	174869045	6046215	28	15368											
NKAPL	222698	broad.mit.edu	37	chr6	28227813	28227813	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actctgatgatgataaaaagAgagttaaagccaagaagaaa	9	4	1	6			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr6:28227813A>G	uc003nkt.2	+	1	716	c.664A>G	c.(664-666)AGA>GGA	p.R222G	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	222	Lys-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						TGATAAAAAGAGAGTTAAAGC	0.254													G	28227813	G	G	28227813	3	3	220	1	0	0	0	0	1	0	0	0	10440	296	11	4	666	4	NKAPL	6	28227813	Missense_Mutation	SNP	A	TCGA-28-6450-01A-11D-1696-08		28227813	142887254	29	15369											
PPP1R10	5514	broad.mit.edu	37	chr6	30573989	30573989	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgctggcattcttcttcacAggcaccaaggatggtgtctc	11	11	4	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr6:30573989A>G	uc003nqn.1	-	9	1218	c.666T>C	c.(664-666)CCT>CCC	p.P222P	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	222	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						TCTTCTTCACAGGCACCAAGG	0.527													G	30573989	G	G	30573989	2	3	220	1	0	0	0	0	0	0	0	1	12352	175	7	4		4	PPP1R10	6	30573989	Silent	SNP	A	TCGA-28-6450-01A-11D-1696-08	2346176	30573989	140541078	30	15370											
COL11A2	1302	broad.mit.edu	37	chr6	33141808	33141808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgtggggccccgttctccccGaggccctgacttccccgaca	11	19	1	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr6:33141808G>A	uc003ocx.1	-	33	2737	c.2509C>T	c.(2509-2511)CGG>TGG	p.R837W	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.R751W|COL11A2_uc003ocz.1_Missense_Mutation_p.R730W	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	837	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CGTTCTCCCCGAGGCCCTGAC	0.612													A	33141808	A	A	33141808	3	1	220	1	0	0	0	0	1	0	0	0	3668	1057	37	2	2837	2	COL11A2	6	33141808	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	2567819	33141808	137973259	31	15371											
NOX3	50508	broad.mit.edu	37	chr6	155743956	155743957	+	Missense_Mutation	DNP	TC	AA	AA													tgggtagtgaaatacatctgTcagggcagttccaaagggcc							TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr6:155743956_155743957TC>AA	uc003qqm.2	-	10	1282_1283	c.1179_1180GA>TT	c.(1177-1182)CTGACA>CTTTCA	p.T394S		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	394	Extracellular (Potential).|FAD-binding FR-type.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		AATACATCTGTCAGGGCAGTTC	0.52													AA	155743957	AA	AA	155743956	3	1	220	1	0	0	0	0	1	0	0	0	10557	1667	58	5	542	5	NOX3	6	155743956	Missense_Mutation	DNP	TC	TCGA-28-6450-01A-11D-1696-08	122602148	155743956	15371111	32	15372											
PPP1R9A	55607	broad.mit.edu	37	chr7	94827740	94827740	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacactggaacaggagaggCgccagagagagctgctggaa	16	8	0	4			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr7:94827740C>T	uc003unp.2	+	6	2116	c.1834C>T	c.(1834-1836)CGC>TGC	p.R612C	PPP1R9A_uc010lfj.2_Missense_Mutation_p.R612C|PPP1R9A_uc011kif.1_Missense_Mutation_p.R612C|PPP1R9A_uc003unq.2_Missense_Mutation_p.R612C|PPP1R9A_uc011kig.1_Missense_Mutation_p.R612C	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	612	Potential.|Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			ACAGGAGAGGCGCCAGAGAGA	0.448										HNSCC(28;0.073)			T	94827740	T	T	94827740	3	4	220	1	0	0	0	0	1	0	0	0	12378	768	27	1	1852	1	PPP1R9A	7	94827740	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08		94827740	64310923	33	15373											
EPHB6	2051	broad.mit.edu	37	chr7	142561895	142561895	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gactccacttctctgtgcggGcatgctccagcctgggtgtg	13	13	1	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr7:142561895G>A	uc011kst.1	+	7	1124	c.337G>A	c.(337-339)GCA>ACA	p.A113T	EPHB6_uc011ksu.1_Missense_Mutation_p.A113T|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_5'UTR	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	113	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CTCTGTGCGGGCATGCTCCAG	0.657													A	142561895	A	A	142561895	3	1	220	1	0	0	0	0	1	0	0	0	5178	1203	42	3	347	3	EPHB6	7	142561895	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	47734155	142561895	16576768	34	15374											
IDO1	3620	broad.mit.edu	37	chr8	39781104	39781104	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagtgtttcaccaaatccaCggcaagtgttgtgtgcagtg	11	9	1	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr8:39781104C>T	uc003xnm.2	+	7	768	c.654C>T	c.(652-654)CAC>CAT	p.H218H	IDO1_uc003xnn.2_RNA	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	218					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	ACCAAATCCACGGCAAGTGTT	0.433													T	39781104	T	T	39781104	2	4	220	1	0	0	0	0	0	0	0	1	7501	550	19	1		1	IDO1	8	39781104	Silent	SNP	C	TCGA-28-6450-01A-11D-1696-08		39781104	106582918	35	15375											
TAF1L	138474	broad.mit.edu	37	chr9	32632187	32632187	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgacagctgagagctggtttTcttgttctgcaacatgttct	10	8	3	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr9:32632187T>C	uc003zrg.1	-	1	3481	c.3391A>G	c.(3391-3393)AAA>GAA	p.K1131E	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1131					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GAGCTGGTTTTCTTGTTCTGC	0.468													C	32632187	C	C	32632187	3	2	220	1	0	0	0	0	1	0	0	0	15520	1792	62	4	2093	4	TAF1L	9	32632187	Missense_Mutation	SNP	T	TCGA-28-6450-01A-11D-1696-08		32632187	108581244	36	15376											
GPR107	57720	broad.mit.edu	37	chr9	132842036	132842036	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cttcagcaggcaaccagaccCagaagacacaaggtaaaccg	9	13	1	3			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr9:132842036C>G	uc004bze.2	+	5	741	c.514C>G	c.(514-516)CAG>GAG	p.Q172E	GPR107_uc004bzb.2_5'UTR|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.Q172E|GPR107_uc004bzd.2_Missense_Mutation_p.Q172E	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	172						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				CAACCAGACCCAGAAGACACA	0.433													G	132842036	G	G	132842036	3	3	220	1	0	0	0	0	1	0	0	0	6623	595	21	5	532	5	GPR107	9	132842036	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	100209849	132842036	8371395	37	15377											
CUBN	8029	broad.mit.edu	37	chr10	16873370	16873370	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtttggcagcagagttccaCagtacttgcccagtaatggt	12	9	0	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr10:16873370C>T	uc001ioo.2	-	65	10461	c.10409G>A	c.(10408-10410)TGT>TAT	p.C3470Y		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3470	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGAGTTCCACAGTACTTGCC	0.368													T	16873370	T	T	16873370	3	4	220	1	0	0	0	0	1	0	0	0	4051	478	17	3	474	3	CUBN	10	16873370	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08		16873370	118661377	38	15378											
ARMC3	219681	broad.mit.edu	37	chr10	23287264	23287264	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcgttctgcaaacacagtcGtgcagagcaaagctgctctc	10	12	2	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr10:23287264G>A	uc001irm.3	+	11	1446	c.1363G>A	c.(1363-1365)GTG>ATG	p.V455M	ARMC3_uc010qcv.1_Missense_Mutation_p.V455M|ARMC3_uc010qcw.1_Missense_Mutation_p.V192M	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	455	ARM 11.						binding				0						AAACACAGTCGTGCAGAGCAA	0.498													A	23287264	A	A	23287264	3	1	220	1	0	0	0	0	1	0	0	0	952	1145	40	1	1401	1	ARMC3	10	23287264	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	6413894	23287264	112247483	39	15379											
MICAL2	9645	broad.mit.edu	37	chr11	12261088	12261088	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatggcgaatcagctgctgGccaagtttgaggagagcact	13	10	1	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr11:12261088G>A	uc001mjz.2	+	17	2458	c.2170G>A	c.(2170-2172)GCC>ACC	p.A724T	MICAL2_uc010rch.1_Missense_Mutation_p.A724T|MICAL2_uc001mka.2_Missense_Mutation_p.A724T|MICAL2_uc010rci.1_Missense_Mutation_p.A724T|MICAL2_uc001mkb.2_Missense_Mutation_p.A724T|MICAL2_uc001mkc.2_Missense_Mutation_p.A724T|MICAL2_uc001mkd.2_Missense_Mutation_p.A553T|MICAL2_uc010rcj.1_Missense_Mutation_p.A126T|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	724						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TCAGCTGCTGGCCAAGTTTGA	0.493													A	12261088	A	A	12261088	3	1	220	1	0	0	0	0	1	0	0	0	9570	1203	42	3	2228	3	MICAL2	11	12261088	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08		12261088	122745428	40	15380											
ABCC9	10060	broad.mit.edu	37	chr12	21954093	21954093	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacaataaccaggtctgccGtcagaatagtgtgtactcga	9	10	3	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr12:21954093G>A	uc001rfh.2	-	38	4555	c.4535C>T	c.(4534-4536)ACG>ATG	p.T1512M	ABCC9_uc001rfg.2_Missense_Mutation_p.T41M	NM_020297	NP_064693	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1512	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGGTCTGCCGTCAGAATAGT	0.383													A	21954093	A	A	21954093	3	1	220	1	0	0	0	0	1	0	0	0	59	1145	40	1	118	1	ABCC9	12	21954093	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08		21954093	111897802	41	15381											
OR6C75	390323	broad.mit.edu	37	chr12	55758950	55758950	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttggattgacaagtgaccCacagtggcaggttgtacttt	11	8	1	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr12:55758950C>T	uc010spk.1	+	1	56	c.56C>T	c.(55-57)CCA>CTA	p.P19L		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						ACAAGTGACCCACAGTGGCAG	0.363													T	55758950	T	T	55758950	3	4	220	1	0	0	0	0	1	0	0	0	11199	594	21	3	58	3	OR6C75	12	55758950	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	33804857	55758950	78092945	42	15382											
CUX2	23316	broad.mit.edu	37	chr12	111742051	111742051	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgggaggtggaaagtctccGggaacagctggcctctgtca	16	10	3	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr12:111742051G>A	uc001tsa.1	+	10	944	c.791G>A	c.(790-792)CGG>CAG	p.R264Q		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	264	Potential.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GAAAGTCTCCGGGAACAGCTG	0.652													A	111742051	A	A	111742051	3	1	220	1	0	0	0	0	1	0	0	0	4065	1116	39	2	829	2	CUX2	12	111742051	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	55983101	111742051	22109844	43	15383											
LCP1	3936	broad.mit.edu	37	chr13	46718596	46718596	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctgtacaaatgattgactcGagggttaacacccagggagt	11	9	0	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr13:46718596G>A	uc001vaz.3	-	11	1360	c.1234C>T	c.(1234-1236)CGA>TGA	p.R412*	LCP1_uc010ack.2_5'Flank|LCP1_uc001vay.3_Nonsense_Mutation_p.R9*|LCP1_uc001vba.3_Nonsense_Mutation_p.R412*	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	412	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TGATTGACTCGAGGGTTAACA	0.418			T	BCL6	NHL 								A	46718596	A	A	46718596	4	1	220	1	0	0	0	0	0	1	0	0	8691	1066	37	2	673	2	LCP1	13	46718596	Nonsense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08		46718596	68451282	44	15384											
RGS6	9628	broad.mit.edu	37	chr14	72943451	72943451	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tgcttgcttcttctcctagtCcgtgtatggcgtgactgaag	11	10	2	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr14:72943451C>G	uc001xna.3	+	11	1218	c.695C>G	c.(694-696)TCC>TGC	p.S232C	RGS6_uc010ttn.1_Missense_Mutation_p.S232C|RGS6_uc001xmx.3_Missense_Mutation_p.S232C|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.S232C|RGS6_uc010ttp.1_Missense_Mutation_p.S163C|RGS6_uc001xmz.1_Missense_Mutation_p.S93C	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	232					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		TTCTCCTAGTCCGTGTATGGC	0.323													G	72943451	G	G	72943451	3	3	220	1	0	0	0	0	1	0	0	0	13309	869	30	5	733	5	RGS6	14	72943451	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08		72943451	34406089	45	15385											
CCPG1	9236	broad.mit.edu	37	chr15	55652658	55652658	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aacgctgctgttcgaaggttAgcttccgttccagctcagtg	11	11	1	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr15:55652658A>G	uc002acv.1	-	8	1478	c.1313T>C	c.(1312-1314)CTA>CCA	p.L438P	CCPG1_uc002acy.2_Missense_Mutation_p.L438P|CCPG1_uc002acu.1_Missense_Mutation_p.L294P|CCPG1_uc002acw.1_Missense_Mutation_p.L163P|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Missense_Mutation_p.L438P|CCPG1_uc002acz.1_Missense_Mutation_p.L438P	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	438	Potential.|Lumenal (Potential).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		TTCGAAGGTTAGCTTCCGTTC	0.413													G	55652658	G	G	55652658	3	3	220	1	0	0	0	0	1	0	0	0	2938	420	15	4	964	4	CCPG1	15	55652658	Missense_Mutation	SNP	A	TCGA-28-6450-01A-11D-1696-08		55652658	46878734	46	15386											
POLG	5428	broad.mit.edu	37	chr15	89876416	89876416	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacaccagggcccgctcctcGgggatggccacgggtacggc	15	15	0	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr15:89876416G>A	uc002bns.3	-	2	852	c.570C>T	c.(568-570)CCC>CCT	p.P190P	POLG_uc002bnr.3_Silent_p.P190P	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	190					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			CCCGCTCCTCGGGGATGGCCA	0.711								DNA_polymerases_(catalytic_subunits)					A	89876416	A	A	89876416	2	1	220	1	0	0	0	0	0	0	0	1	12200	1103	39	2		2	POLG	15	89876416	Silent	SNP	G	TCGA-28-6450-01A-11D-1696-08	34223758	89876416	12654976	47	15387											
IFT140	9742	broad.mit.edu	37	chr16	1574572	1574572	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccttgcacaggcggatggcaTtcttgaaggcctgtgcccgg	14	12	1	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr16:1574572T>A	uc002cmb.2	-	24	3484	c.3122A>T	c.(3121-3123)AAT>ATT	p.N1041I	IFT140_uc002clz.2_Missense_Mutation_p.N654I	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	1041	TPR 5.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				GCGGATGGCATTCTTGAAGGC	0.652													A	1574572	A	A	1574572	3	1	220	1	0	0	0	0	1	0	0	0	7556	1493	52	5	1298	5	IFT140	16	1574572	Missense_Mutation	SNP	T	TCGA-28-6450-01A-11D-1696-08		1574572	88780181	48	15388											
ZNF768	79724	broad.mit.edu	37	chr16	30535896	30535897	+	Missense_Mutation	DNP	AA	GC	GC													tgaggtcggagctctgggagAaggcctttccgcagtcatcg							TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr16:30535896_30535897AA>GC	uc002dyk.3	-	2	1740_1741	c.1564_1565TT>GC	c.(1564-1566)TTC>GCC	p.F522A	ZNF768_uc010vex.1_Missense_Mutation_p.F491A|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.F491A	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	522	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						GCTCTGGGAGAAGGCCTTTCCG	0.678													GC	30535897	GC	GC	30535896	3	3	220	1	0	0	0	0	1	0	0	0	18138	246	9	4	61	4	ZNF768	16	30535896	Missense_Mutation	DNP	AA	TCGA-28-6450-01A-11D-1696-08	28961324	30535896	59818857	49	15389											
ZNF629	23361	broad.mit.edu	37	chr16	30795519	30795519	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agccgggtctcccatgatgaTctcctccccagaactttcct	7	16	2	3			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr16:30795519T>G	uc002dzs.1	-	3	338	c.130A>C	c.(130-132)ATC>CTC	p.I44L		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	44					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			CCCATGATGATCTCCTCCCCA	0.577													G	30795519	G	G	30795519	3	3	220	1	0	0	0	0	1	0	0	0	18050	1435	50	5	2483	5	ZNF629	16	30795519	Missense_Mutation	SNP	T	TCGA-28-6450-01A-11D-1696-08	259623	30795519	59559234	50	15390											
PKD1L2	114780	broad.mit.edu	37	chr16	81151072	81151072	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagctggccaggatgatgGccagctccagaaggttccac	12	13	0	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr16:81151072G>A	uc002fgh.1	-	41	6677	c.6677C>T	c.(6676-6678)GCC>GTC	p.A2226V	PKD1L2_uc002fgf.1_Missense_Mutation_p.A26V|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2226	Helical; (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAGGATGATGGCCAGCTCCAG	0.612													A	81151072	A	A	81151072	3	1	220	1	0	0	0	0	1	0	0	0	11965	1203	42	3	722	3	PKD1L2	16	81151072	Missense_Mutation	SNP	G	TCGA-28-6450-01A-11D-1696-08	50355553	81151072	9203681	51	15391											
NF1	4763	broad.mit.edu	37	chr17	29527568	29527569	+	Frame_Shift_Del	DEL	CT	-	-													tacatcaattgggaagataaCtctgtcattttcctacttgt							TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr17:29527568_29527569delCT	uc002hgg.2	+	9	1350_1351	c.1017_1018delCT	c.(1015-1020)AACTCTfs	p.N339fs	NF1_uc002hge.1_Frame_Shift_Del_p.N339fs|NF1_uc002hgf.1_Frame_Shift_Del_p.N339fs|NF1_uc002hgh.2_Frame_Shift_Del_p.N339fs|NF1_uc010csn.1_Frame_Shift_Del_p.N199fs	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	339_340					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GGGAAGATAACTCTGTCATTTT	0.381			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29527569	-	-	29527568	7	5	220	1	0	1	0	1	0	0	0	0	10356	564	20	0	1051	0	NF1	17	29527568	Frame_Shift_Del	DEL	CT	TCGA-28-6450-01A-11D-1696-08		29527568	51667642	52	15392											
NF1	4763	broad.mit.edu	37	chr17	29684388	29684391	+	Splice_Site	DEL	GTAA	-	-													cccaaagtctttcctgttgtGtaagtatctccttttgattt							TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr17:29684388_29684391delGTAA	uc002hgg.2	+	54	8303	c.7970_splice	c.e54+1	p.V2657_splice	NF1_uc002hgh.2_Splice_Site_p.V2636_splice|NF1_uc010cso.2_Splice_Site_p.V845_splice|NF1_uc010wbt.1_Splice_Site_p.V135_splice|NF1_uc010wbu.1_Splice_Site	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTCCTGTTGTGTAAGTATCTCCTT	0.377			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29684391	-	-	29684388	8	5	220	1	0	1	0	1	0	0	1	0	10356	1391	48	0	8246	0	NF1	17	29684388	Splice_Site	DEL	GTAA	TCGA-28-6450-01A-11D-1696-08	156820	29684388	51510822	53	15393											
KRT31	3881	broad.mit.edu	37	chr17	39550299	39550299	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggaattgcagggcccacagCgggggcgtggggcacagggt	20	9	0	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr17:39550299C>T	uc002hwn.2	-	7	1273	c.1220G>A	c.(1219-1221)CGC>CAC	p.R407H	KRT31_uc010cxn.2_3'UTR	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	407	Tail.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				GGGCCCACAGCGGGGGCGTGG	0.632													T	39550299	T	T	39550299	3	4	220	1	0	0	0	0	1	0	0	0	8467	768	27	1	34	1	KRT31	17	39550299	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	9865911	39550299	41644911	54	15394											
LAMA1	284217	broad.mit.edu	37	chr18	6985300	6985300	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcagctctgtagaccaggtCgactgcgttcctttgggaca	11	12	2	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr18:6985300C>T	uc002knm.2	-	39	5690	c.5596G>A	c.(5596-5598)GAC>AAC	p.D1866N	LAMA1_uc010wzj.1_Missense_Mutation_p.D1342N	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1866	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAGACCAGGTCGACTGCGTTC	0.507													T	6985300	T	T	6985300	3	4	220	1	0	0	0	0	1	0	0	0	8605	884	31	2	3731	2	LAMA1	18	6985300	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08		6985300	71091948	55	15395											
ME2	4200	broad.mit.edu	37	chr18	48450505	48450505	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agatagttatcaggaaccatTtactcactcagccccagaga	7	11	3	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr18:48450505T>G	uc002ley.2	+	11	1350	c.1094T>G	c.(1093-1095)TTT>TGT	p.F365C	ME2_uc010dpd.2_Missense_Mutation_p.F365C	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	365					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	CAGGAACCATTTACTCACTCA	0.313													G	48450505	G	G	48450505	3	3	220	1	0	0	0	0	1	0	0	0	9418	1841	64	5	1132	5	ME2	18	48450505	Missense_Mutation	SNP	T	TCGA-28-6450-01A-11D-1696-08	41465205	48450505	29626743	56	15396											
ZNF350	59348	broad.mit.edu	37	chr19	52472376	52472376	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acagccacatcctccagtgtTatggattcctgtaataacag	7	11	0	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr19:52472376T>C	uc002pyd.2	-	3	252	c.24A>G	c.(22-24)ATA>ATG	p.I8M	uc002pyb.2_Intron|uc002pyc.2_Intron	NM_021632	NP_067645	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	8	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(1)	1		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		CCTCCAGTGTTATGGATTCCT	0.453													C	52472376	C	C	52472376	3	2	220	1	0	0	0	0	1	0	0	0	17860	1744	61	4	1586	4	ZNF350	19	52472376	Missense_Mutation	SNP	T	TCGA-28-6450-01A-11D-1696-08		52472376	6656607	57	15397											
PEG3	5178	broad.mit.edu	37	chr19	57327924	57327924	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagtctccccacacaccttaCattcgtacattttctcttta	2	14	2	0	rs140555816	by1000genomes	TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr19:57327924C>G	uc002qnu.2	-	7	2237	c.1886G>C	c.(1885-1887)TGT>TCT	p.C629S	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.C600S|PEG3_uc002qnv.2_Missense_Mutation_p.C629S|PEG3_uc002qnw.2_Missense_Mutation_p.C505S|PEG3_uc002qnx.2_Missense_Mutation_p.C503S|PEG3_uc010etr.2_Missense_Mutation_p.C629S	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	629	C2H2-type 4.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACACACCTTACATTCGTACAT	0.388													G	57327924	G	G	57327924	3	3	220	1	0	0	0	0	1	0	0	0	11720	478	17	5	2884	5	PEG3	19	57327924	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	4855548	57327924	1801059	58	15398			1	41		4	4	621	C		4.185408e-10
PEG3	5178	broad.mit.edu	37	chr19	57327945	57327945	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	attcgtacattttctctttaCcatacattttctgaaactca	2	10	3	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr19:57327945C>G	uc002qnu.2	-	7	2216	c.1865G>C	c.(1864-1866)GGT>GCT	p.G622A	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G593A|PEG3_uc002qnv.2_Missense_Mutation_p.G622A|PEG3_uc002qnw.2_Missense_Mutation_p.G498A|PEG3_uc002qnx.2_Missense_Mutation_p.G496A|PEG3_uc010etr.2_Missense_Mutation_p.G622A	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	622					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTTCTCTTTACCATACATTTT	0.363													G	57327945	G	G	57327945	3	3	220	1	0	0	0	0	1	0	0	0	11720	507	18	5	2905	5	PEG3	19	57327945	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	21	57327945	1801038	59	15399			1	41		4	4	621	C		4.185408e-10
PEG3	5178	broad.mit.edu	37	chr19	57328102	57328102	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	agaactatgaaggaaggtttCcttacacaccctgcactcgt	8	11	0	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr19:57328102C>G	uc002qnu.2	-	7	2059	c.1708G>C	c.(1708-1710)GAA>CAA	p.E570Q	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E541Q|PEG3_uc002qnv.2_Missense_Mutation_p.E570Q|PEG3_uc002qnw.2_Missense_Mutation_p.E446Q|PEG3_uc002qnx.2_Missense_Mutation_p.E444Q|PEG3_uc010etr.2_Missense_Mutation_p.E570Q	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	570	C2H2-type 3.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGGAAGGTTTCCTTACACACC	0.368													G	57328102	G	G	57328102	3	3	220	1	0	0	0	0	1	0	0	0	11720	864	30	5	3062	5	PEG3	19	57328102	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	157	57328102	1800881	60	15400			1	41		4	4	621	C		4.185408e-10
PEG3	5178	broad.mit.edu	37	chr19	57328544	57328544	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctcacgctcatggcttttctCatctcactaccacattcaaa	3	15	5	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr19:57328544C>G	uc002qnu.2	-	7	1617	c.1266G>C	c.(1264-1266)ATG>ATC	p.M422I	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.M393I|PEG3_uc002qnv.2_Missense_Mutation_p.M422I|PEG3_uc002qnw.2_Missense_Mutation_p.M298I|PEG3_uc002qnx.2_Missense_Mutation_p.M296I|PEG3_uc010etr.2_Missense_Mutation_p.M422I	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	422					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGGCTTTTCTCATCTCACTAC	0.493													G	57328544	G	G	57328544	3	3	220	1	0	0	0	0	1	0	0	0	11720	826	29	5	3504	5	PEG3	19	57328544	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	442	57328544	1800439	61	15401			1	41		4	4	621	C		4.185408e-10
SLC12A5	57468	broad.mit.edu	37	chr20	44669236	44669236	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggggtcatcaagtctgccttCgacccacccaacttcccgtg	9	16	3	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr20:44669236C>T	uc010zxl.1	+	7	982	c.906C>T	c.(904-906)TTC>TTT	p.F302F	SLC12A5_uc002xra.2_Silent_p.F279F|SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Silent_p.F279F	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	302	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGTCTGCCTTCGACCCACCCA	0.557													T	44669236	T	T	44669236	2	4	220	1	0	0	0	0	0	0	0	1	14386	883	31	2		2	SLC12A5	20	44669236	Silent	SNP	C	TCGA-28-6450-01A-11D-1696-08		44669236	18356284	62	15402											
STAU1	6780	broad.mit.edu	37	chr20	47734907	47734907	+	Frame_Shift_Del	DEL	G	-	-													ccagagccaggttcaaaaaaGgttacttttcttccatcccc							TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chr20:47734907delG	uc002xud.2	-	10	1563	c.1152delC	c.(1150-1152)ACCfs	p.T384fs	STAU1_uc002xua.2_Frame_Shift_Del_p.T303fs|STAU1_uc002xub.2_Frame_Shift_Del_p.T309fs|STAU1_uc002xuc.2_Frame_Shift_Del_p.T303fs|STAU1_uc002xue.2_Frame_Shift_Del_p.T303fs|STAU1_uc002xuf.2_Frame_Shift_Del_p.T309fs|STAU1_uc002xug.2_Frame_Shift_Del_p.T384fs	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	384				QPTKPALKSEEKTPIKKPGDGRKVTFFEPGSGD -> SHQT RTQVRGEDTHKETRGWKKSNLFLNLALGM (in Ref. 2).		microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			GTTCAAAAAAGGTTACTTTTC	0.388													-	47734907	-	-	47734907	7	5	220	1	0	1	0	1	0	0	0	0	15271	987	35	0	601	0	STAU1	20	47734907	Frame_Shift_Del	DEL	G	TCGA-28-6450-01A-11D-1696-08	3065671	47734907	15290613	63	15403											
KLHL34	257240	broad.mit.edu	37	chrX	21675508	21675508	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgcgctgccacgttggcggcGaagcagcagttctctggagc	15	13	1	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chrX:21675508G>A	uc004czz.1	-	1	941	c.399C>T	c.(397-399)TTC>TTT	p.F133F		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	133	BACK.									ovary(1)	1						CGTTGGCGGCGAAGCAGCAGT	0.627													A	21675508	A	A	21675508	2	1	220	1	0	0	0	0	0	0	0	1	8387	1049	37	2		2	KLHL34	23	21675508	Silent	SNP	G	TCGA-28-6450-01A-11D-1696-08		21675508	133595052	64	15404											
GPR34	2857	broad.mit.edu	37	chrX	41555067	41555067	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctactgtgttaaccacatccTactctgttattttcatcgtg	5	11	2	0			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chrX:41555067T>C	uc004dfp.3	+	3	465	c.181T>C	c.(181-183)TAC>CAC	p.Y61H	CASK_uc004dfl.3_Intron|CASK_uc004dfm.3_Intron|CASK_uc004dfn.3_Intron|GPR34_uc004dfq.3_Missense_Mutation_p.Y61H|GPR34_uc010nhg.2_Missense_Mutation_p.Y61H|GPR34_uc004dfr.3_Missense_Mutation_p.Y61H	NM_001097579	NP_001091048	Q9UPC5	GPR34_HUMAN	G protein-coupled receptor 34	61	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						AACCACATCCTACTCTGTTAT	0.398													C	41555067	C	C	41555067	3	2	220	1	0	0	0	0	1	0	0	0	6689	1522	53	4	183	4	GPR34	23	41555067	Missense_Mutation	SNP	T	TCGA-28-6450-01A-11D-1696-08	19879559	41555067	113715493	65	15405											
MAGEC3	139081	broad.mit.edu	37	chrX	140967026	140967026	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcattttgggagtcagccGgaggggaagttttctctgag	15	6	2	1			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chrX:140967026G>A	uc011mwp.1	+	3	324	c.324G>A	c.(322-324)CCG>CCA	p.P108P		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	108										skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGAGTCAGCCGGAGGGGAAGT	0.562													A	140967026	A	A	140967026	2	1	220	1	0	0	0	0	0	0	0	1	9182	1103	39	2		2	MAGEC3	23	140967026	Silent	SNP	G	TCGA-28-6450-01A-11D-1696-08	99411959	140967026	14303534	66	15406											
ZNF275	10838	broad.mit.edu	37	chrX	152612297	152612297	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagcacctccgcgacccgaCaccagatgaagggggaagat	12	12	0	3			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chrX:152612297C>T	uc004fhg.1	+	4	331	c.154C>T	c.(154-156)CAC>TAC	p.H52Y	ZNF275_uc011mym.1_Missense_Mutation_p.H52Y|ZNF275_uc011myn.1_5'UTR			A6NFS0	A6NFS0_HUMAN	SubName: Full=cDNA FLJ16723 fis, clone UTERU3004418, highly similar to Zinc finger protein 275; SubName: Full=Putative uncharacterized protein ZNF275;	52						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGCGACCCGACACCAGATGAA	0.552													T	152612297	T	T	152612297	3	4	220	1	0	0	0	0	1	0	0	0	17807	478	17	3	164	3	ZNF275	23	152612297	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	11645271	152612297	2658263	67	15407											
L1CAM	3897	broad.mit.edu	37	chrX	153128302	153128302	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcccaggggcttgatgtccCcgttgagcgatggctggctg	16	11	0	2			TCGA-28-6450-01A-11D-1696-08	TCGA-28-6450-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5f10d0c5-05b8-44bb-98ce-bbea41820850	502b40b2-43eb-4d96-bce9-8ea7b8ee2289	g.chrX:153128302C>T	uc004fjb.2	-	28	3698	c.3590G>A	c.(3589-3591)GGG>GAG	p.G1197E	L1CAM_uc004fjc.2_Missense_Mutation_p.G1193E|L1CAM_uc010nuo.2_Missense_Mutation_p.G1188E	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	1197	Cytoplasmic (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTTGATGTCCCCGTTGAGCGA	0.607													T	153128302	T	T	153128302	3	4	220	1	0	0	0	0	1	0	0	0	8588	623	22	3	187	3	L1CAM	23	153128302	Missense_Mutation	SNP	C	TCGA-28-6450-01A-11D-1696-08	516005	153128302	2142258	68	15408											
KIAA0562	9731	broad.mit.edu	37	chr1	3732029	3732029	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cccttcggggtggggatcttGcttccggcctttgaccccaa	12	14	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:3732029G>C	uc001aky.2	-	22	3074	c.2715C>G	c.(2713-2715)AGC>AGG	p.S905R	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	905						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		TGGGGATCTTGCTTCCGGCCT	0.642													C	3732029	C	C	3732029	3	2	221	1	0	0	0	0	1	0	0	0	8184	1310	46	5	66	5	KIAA0562	1	3732029	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08		3732029	245518592	1	15409											
TNFRSF8	943	broad.mit.edu	37	chr1	12164492	12164492	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctcccgtgtctgcgaatgtCgacccggcatgttctgttcc	10	15	2	0	rs148756853		TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:12164492C>T	uc001atq.2	+	4	547	c.325C>T	c.(325-327)CGA>TGA	p.R109*	TNFRSF8_uc010obc.1_5'UTR	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	109	TNFR-Cys 3.|Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCGAATGTCGACCCGGCAT	0.577													T	12164492	T	T	12164492	4	4	221	1	0	0	0	0	0	1	0	0	16296	876	31	2	339	2	TNFRSF8	1	12164492	Nonsense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	8432463	12164492	237086129	2	15410											
DPH2	1802	broad.mit.edu	37	chr1	44437537	44437537	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tatgtgttggccctggggcgGcccacccctgccaagcttgc	13	15	0	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:44437537G>T	uc001ckz.2	+	4	1158	c.963G>T	c.(961-963)CGG>CGT	p.R321R	DPH2_uc001cla.2_Intron|DPH2_uc010okk.1_Silent_p.R186R|DPH2_uc001clb.2_Silent_p.R245R	NM_001384	NP_001375	Q9BQC3	DPH2_HUMAN	diphthamide biosynthesis protein 2 isoform a	321					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				CCCTGGGGCGGCCCACCCCTG	0.607													T	44437537	T	T	44437537	2	4	221	1	0	0	0	0	0	0	0	1	4720	1190	42	5		5	DPH2	1	44437537	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08	32273045	44437537	204813084	3	15411											
PTGFR	5737	broad.mit.edu	37	chr1	79002163	79002163	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacaacactttttgctctcCgaatggcaacatggaatcaa	6	10	2	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:79002163C>T	uc001din.2	+	3	1137	c.871C>T	c.(871-873)CGA>TGA	p.R291*	PTGFR_uc001dim.2_3'UTR	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	291	Helical; Name=7; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	TTTTGCTCTCCGAATGGCAAC	0.388													T	79002163	T	T	79002163	4	4	221	1	0	0	0	0	0	1	0	0	12749	644	23	2	952	2	PTGFR	1	79002163	Nonsense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	34564626	79002163	170248458	4	15412											
HRNR	388697	broad.mit.edu	37	chr1	152193260	152193260	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cagacccatgctgaccatagCtggaagacgaacctgagcta	10	12	0	4			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:152193260C>G	uc001ezt.1	-	3	921	c.845G>C	c.(844-846)AGC>ACC	p.S282T		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	282	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGACCATAGCTGGAAGACGA	0.587													G	152193260	G	G	152193260	3	3	221	1	0	0	0	0	1	0	0	0	7359	797	28	5	7711	5	HRNR	1	152193260	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	73191097	152193260	97057361	5	15413											
IQGAP3	128239	broad.mit.edu	37	chr1	156518190	156518190	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gttgagggggcagccaggagGttgctcccagatcccctgga	16	11	0	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:156518190G>C	uc001fpf.2	-	18	2158	c.2083C>G	c.(2083-2085)CCT>GCT	p.P695A		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	695					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAGCCAGGAGGTTGCTCCCAG	0.557													C	156518190	C	C	156518190	3	2	221	1	0	0	0	0	1	0	0	0	7816	1261	44	5	2896	5	IQGAP3	1	156518190	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	4324930	156518190	92732431	6	15414											
ASPM	259266	broad.mit.edu	37	chr1	197061071	197061071	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgaattaacctgcttgttaGcattcttcacagccaggtaa	7	10	2	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:197061071G>T	uc001gtu.2	-	22	9667	c.9410C>A	c.(9409-9411)GCT>GAT	p.A3137D	ASPM_uc001gtv.2_Missense_Mutation_p.A1552D|ASPM_uc001gtw.3_Missense_Mutation_p.A985D	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	3137					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CTGCTTGTTAGCATTCTTCAC	0.338													T	197061071	T	T	197061071	3	4	221	1	0	0	0	0	1	0	0	0	1056	971	34	5	1051	5	ASPM	1	197061071	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	40542881	197061071	52189550	7	15415											
OR2W5	441932	broad.mit.edu	37	chr1	247654810	247654810	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccgctatgtggccgtctgCcggtccctgcactacatggc	12	15	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:247654810C>T	uc001icz.1	+	1	381	c.381C>T	c.(379-381)TGC>TGT	p.C127C		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGGCCGTCTGCCGGTCCCTGC	0.587													T	247654810	T	T	247654810	2	4	221	1	0	0	0	0	0	0	0	1	11034	747	26	3		3	OR2W5	1	247654810	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	50593739	247654810	1595811	8	15416											
TRIM58	25893	broad.mit.edu	37	chr1	248039235	248039235	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatcccgccacggcgcaccCgagtctgctcttgaccgccg	12	18	2	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:248039235C>T	uc001ido.2	+	6	953	c.905C>T	c.(904-906)CCG>CTG	p.P302L	OR2W3_uc001idp.1_5'UTR	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	302	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			ACGGCGCACCCGAGTCTGCTC	0.557													T	248039235	T	T	248039235	3	4	221	1	0	0	0	0	1	0	0	0	16528	652	23	2	927	2	TRIM58	1	248039235	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	384425	248039235	1211386	9	15417											
OR2L3	391192	broad.mit.edu	37	chr1	248224640	248224640	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atttcatgttcctatggccgGgttctccttgctgtctacca	8	12	3	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:248224640G>T	uc001idx.1	+	1	657	c.657G>T	c.(655-657)CGG>CGT	p.R219R	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	219	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CCTATGGCCGGGTTCTCCTTG	0.498													T	248224640	T	T	248224640	2	4	221	1	0	0	0	0	0	0	0	1	11008	1219	43	5		5	OR2L3	1	248224640	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08	185405	248224640	1025981	10	15418											
OR2G6	391211	broad.mit.edu	37	chr1	248685400	248685400	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccggtggagcatggctcagCggcctcatcacctccctaat	11	15	3	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr1:248685400C>T	uc001ien.1	+	1	453	c.453C>T	c.(451-453)AGC>AGT	p.S151S		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CATGGCTCAGCGGCCTCATCA	0.577													T	248685400	T	T	248685400	2	4	221	1	0	0	0	0	0	0	0	1	11000	767	27	1		1	OR2G6	1	248685400	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	460760	248685400	565221	11	15419											
EHD3	30845	broad.mit.edu	37	chr2	31484475	31484475	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctcggtgttcgggaaggacAacaagaagaaggagctggtc	15	8	0	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr2:31484475A>T	uc002rnu.2	+	5	1584	c.976A>T	c.(976-978)AAC>TAC	p.N326Y	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	326					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					CGGGAAGGACAACAAGAAGAA	0.552													T	31484475	T	T	31484475	3	4	221	1	0	0	0	0	1	0	0	0	4979	130	5	5	994	5	EHD3	2	31484475	Missense_Mutation	SNP	A	TCGA-32-1970-01A-01D-1494-08		31484475	211714898	12	15420											
DPP10	57628	broad.mit.edu	37	chr2	116497460	116497460	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccaaaggaaagcagtatccGtatcctaaggtaagtaacat	8	9	0	0	rs146251151		TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr2:116497460G>A	uc002tla.1	+	9	1300	c.843G>A	c.(841-843)CCG>CCA	p.P281P	DPP10_uc002tlb.1_Silent_p.P231P|DPP10_uc002tlc.1_Silent_p.P277P|DPP10_uc002tle.2_Silent_p.P285P|DPP10_uc002tlf.1_Silent_p.P274P	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	281	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AGCAGTATCCGTATCCTAAGG	0.423													A	116497460	A	A	116497460	2	1	221	1	0	0	0	0	0	0	0	1	4727	1132	40	1		1	DPP10	2	116497460	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08	85012985	116497460	126701913	13	15421											
UGGT1	56886	broad.mit.edu	37	chr2	128939777	128939777	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttatggttacactcctttctGtgacagccgaagagaaatgg	10	8	1	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr2:128939777G>T	uc002tps.2	+	37	4335	c.4157G>T	c.(4156-4158)TGT>TTT	p.C1386F	UGGT1_uc002tpr.2_Missense_Mutation_p.C1362F	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1386	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						ACTCCTTTCTGTGACAGCCGA	0.418													T	128939777	T	T	128939777	3	4	221	1	0	0	0	0	1	0	0	0	16938	1377	48	5	4303	5	UGGT1	2	128939777	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	12442317	128939777	114259596	14	15422											
GCA	25801	broad.mit.edu	37	chr2	163204170	163204170	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cccagctatactcctcgatgGatactctgggccagcatatt	8	13	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr2:163204170G>C	uc002ucg.2	+	2	286	c.110G>C	c.(109-111)GGA>GCA	p.G37A	GCA_uc010zcu.1_Missense_Mutation_p.G18A	NM_012198	NP_036330	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	37					cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity				0						CTCCTCGATGGATACTCTGGG	0.463													C	163204170	C	C	163204170	3	2	221	1	0	0	0	0	1	0	0	0	6283	1174	41	5	116	5	GCA	2	163204170	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	34264393	163204170	79995203	15	15423											
TTN	7273	broad.mit.edu	37	chr2	179598493	179598493	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgatttttccgtcttctctgAtgacctcttgacctttcatc	5	12	4	4			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr2:179598493A>G	uc010zfg.1	-	50	12115	c.11891T>C	c.(11890-11892)ATC>ACC	p.I3964T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I625T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4891							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTTCTCTGATGACCTCTTG	0.448													G	179598493	G	G	179598493	3	3	221	1	0	0	0	0	1	0	0	0	16732	333	12	4	89146	4	TTN	2	179598493	Missense_Mutation	SNP	A	TCGA-32-1970-01A-01D-1494-08	16394323	179598493	63600880	16	15424											
GLS	2744	broad.mit.edu	37	chr2	191765419	191765419	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaaagcagtctggaggaaaGgtaatgcttttgatgtacat	11	4	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr2:191765419G>A	uc002usf.2	+	4	999	c.735G>A	c.(733-735)AAG>AAA	p.K245K	GLS_uc002use.2_Silent_p.K245K	NM_014905	NP_055720	O94925	GLSK_HUMAN	glutaminase precursor	245					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTGGAGGAAAGGTAATGCTTT	0.323													A	191765419	A	A	191765419	2	1	221	1	0	0	0	0	0	0	0	1	6463	1014	35	3		3	GLS	2	191765419	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08	12166926	191765419	51433954	17	15425											
RBMS3	27303	broad.mit.edu	37	chr3	30032601	30032601	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgctgatacctctccccagaCagtggcaccttcatcccagg	8	16	2	2	rs143165101		TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr3:30032601C>G	uc003cel.2	+	14	1438	c.1208C>G	c.(1207-1209)ACA>AGA	p.T403R	RBMS3_uc003cek.2_Missense_Mutation_p.T387R|RBMS3_uc010hfq.2_Missense_Mutation_p.T400R|RBMS3_uc003cem.2_Missense_Mutation_p.T385R|RBMS3_uc010hfr.2_Missense_Mutation_p.T387R	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	403						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				TCTCCCCAGACAGTGGCACCT	0.483													G	30032601	G	G	30032601	3	3	221	1	0	0	0	0	1	0	0	0	13150	478	17	5	1305	5	RBMS3	3	30032601	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08		30032601	167989829	18	15426											
CCR9	10803	broad.mit.edu	37	chr3	45942421	45942421	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aacaatgtcaggcagtttgcGagccatttcctcccaccctt	7	14	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr3:45942421G>A	uc003coz.1	+	3	298	c.141G>A	c.(139-141)GCG>GCA	p.A47A	LZTFL1_uc003coy.1_Intron|LZTFL1_uc011bak.1_Intron|CCR9_uc010hiv.1_Silent_p.A35A|CCR9_uc003cpa.1_Silent_p.A35A	NM_031200	NP_112477	P51686	CCR9_HUMAN	chemokine (C-C motif) receptor 9 isoform A	47	Extracellular (Potential).				cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane				ovary(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00118)|KIRC - Kidney renal clear cell carcinoma(197;0.0182)|Kidney(197;0.0214)		GGCAGTTTGCGAGCCATTTCC	0.468													A	45942421	A	A	45942421	2	1	221	1	0	0	0	0	0	0	0	1	2948	1045	37	2		2	CCR9	3	45942421	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08	15909820	45942421	152080009	19	15427											
STAB1	23166	broad.mit.edu	37	chr3	52540233	52540233	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggtcggatcctcaccatggcGaaccaggtcctggctgtgaa	13	12	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr3:52540233G>A	uc003dej.2	+	17	1871	c.1797G>A	c.(1795-1797)GCG>GCA	p.A599A	STAB1_uc003dei.1_Silent_p.A599A	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	599	Extracellular (Potential).|FAS1 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TCACCATGGCGAACCAGGTCC	0.622													A	52540233	A	A	52540233	2	1	221	1	0	0	0	0	0	0	0	1	15236	1045	37	2		2	STAB1	3	52540233	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08	6597812	52540233	145482197	20	15428											
GCET2	257144	broad.mit.edu	37	chr3	111852081	111852081	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgtggctctggccacccGtgcagagacagcagaaagga	14	11	1	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr3:111852081G>A	uc003dys.1	-	1	37	c.-113C>T	c.(-115--111)CACGG>CATGG		GCET2_uc003dyt.1_Translation_Start_Site	NM_152785	NP_689998	Q8N6F7	GCET2_HUMAN	germinal center expressed transcript 2 isoform							mitochondrion					0						CTGGCCACCCGTGCAGAGACA	0.557													A	111852081	A	A	111852081	1	1	221	1	0	0	0	0	0	0	0	0	6288	1160	40	1		1	GCET2	3	111852081	Translation_Start_Site	SNP	G	TCGA-32-1970-01A-01D-1494-08	59311848	111852081	86170349	21	15429											
STXBP5L	9515	broad.mit.edu	37	chr3	120764376	120764376	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccattctcttaaatttaaccGggaacggtaagaacctatga	7	9	1	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr3:120764376G>A	uc003eec.3	+	5	604	c.464G>A	c.(463-465)CGG>CAG	p.R155Q	STXBP5L_uc011bji.1_Missense_Mutation_p.R155Q	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	155					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AAATTTAACCGGGAACGGTAA	0.358													A	120764376	A	A	120764376	3	1	221	1	0	0	0	0	1	0	0	0	15356	1116	39	2	478	2	STXBP5L	3	120764376	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	8912295	120764376	77258054	22	15430											
MECOM	2122	broad.mit.edu	37	chr3	168833869	168833869	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcactttccagatcagagccCgaggttgtttccaggtcact	9	12	3	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr3:168833869C>T	uc003ffi.3	-	7	1496	c.1227G>A	c.(1225-1227)TCG>TCA	p.S409S	MECOM_uc010hwk.1_Silent_p.S432S|MECOM_uc003ffj.3_Silent_p.S474S|MECOM_uc011bpi.1_Silent_p.S410S|MECOM_uc003ffn.3_Silent_p.S409S|MECOM_uc003ffk.2_Silent_p.S409S|MECOM_uc003ffl.2_Silent_p.S569S|MECOM_uc011bpj.1_Silent_p.S597S|MECOM_uc011bpk.1_Silent_p.S399S|MECOM_uc010hwn.2_Silent_p.S597S	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	409					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GATCAGAGCCCGAGGTTGTTT	0.423													T	168833869	T	T	168833869	2	4	221	1	0	0	0	0	0	0	0	1	9422	639	23	2		2	MECOM	3	168833869	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	48069493	168833869	29188561	23	15431											
ACAP2	23527	broad.mit.edu	37	chr3	195102729	195102729	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggcttttccagtatcaatcAttgcaatacaaagtttcaca	5	9	3	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr3:195102729A>G	uc003fun.3	-	3	375	c.134T>C	c.(133-135)ATG>ACG	p.M45T	ACAP2_uc003fuo.2_Missense_Mutation_p.M45T	NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	45	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						AGTATCAATCATTGCAATACA	0.343													G	195102729	G	G	195102729	3	3	221	1	0	0	0	0	1	0	0	0	119	217	8	4	2286	4	ACAP2	3	195102729	Missense_Mutation	SNP	A	TCGA-32-1970-01A-01D-1494-08	26268860	195102729	2919701	24	15432											
TNK2	10188	broad.mit.edu	37	chr3	195597005	195597006	+	Frame_Shift_Ins	INS	-	G	G													tttcacccctcctagatgctINSgggggggccgggaggtgctc							TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr3:195597005_195597006insG	uc003fvu.1	-	11	2065_2066	c.1522_1523insC	c.(1522-1524)CAGfs	p.Q508fs	TNK2_uc003fvq.1_5'Flank|TNK2_uc003fvr.1_Frame_Shift_Ins_p.Q18fs|TNK2_uc003fvs.1_Frame_Shift_Ins_p.Q540fs|TNK2_uc003fvt.1_Frame_Shift_Ins_p.Q571fs|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Frame_Shift_Ins_p.Q338fs	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	508				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	TCCTAGATGCTGGGGGGGCCGG	0.614													G	195597006	G	G	195597005	7	5	221	1	0	1	1	0	0	0	0	0	16315	1580	55	0	1662	0	TNK2	3	195597005	Frame_Shift_Ins	INS	-	TCGA-32-1970-01A-01D-1494-08	494276	195597005	2425425	25	15433											
GPR78	27201	broad.mit.edu	37	chr4	8583361	8583361	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaaggcgctcgcgctgctcGccgacctgcaccccaggtat	12	16	0	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr4:8583361G>A	uc003glk.2	+	1	1071	c.652G>A	c.(652-654)GCC>ACC	p.A218T	CPZ_uc003gll.2_RNA	NM_080819	NP_543009	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	218	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|ovary(2)	6						CGCGCTGCTCGCCGACCTGCA	0.687													A	8583361	A	A	8583361	3	1	221	1	0	0	0	0	1	0	0	0	6710	1087	38	1	654	1	GPR78	4	8583361	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08		8583361	182570915	26	15434											
FGB	2244	broad.mit.edu	37	chr4	155487823	155487823	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagaggcagaagcaagtaaaAggtagatatccttgtgcttt	11	5	0	3			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr4:155487823A>T	uc003ioa.3	+	3	528	c.489A>T	c.(487-489)AAA>AAT	p.K163N	FGB_uc010ipu.1_RNA|FGB_uc003iob.3_Missense_Mutation_p.K160N|FGB_uc010ipv.2_Missense_Mutation_p.K101N|FGB_uc010ipw.2_Missense_Mutation_p.K160N|FGB_uc003ioc.3_Intron	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	163	Potential.	Cleavage; by plasmin; to break down fibrin clots.			platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AGCAAGTAAAAGGTAGATATC	0.403													T	155487823	T	T	155487823	3	4	221	1	0	0	0	0	1	0	0	0	5831	86	3	5	499	5	FGB	4	155487823	Missense_Mutation	SNP	A	TCGA-32-1970-01A-01D-1494-08	146904462	155487823	35666453	27	15435											
C5orf42	65250	broad.mit.edu	37	chr5	37167302	37167302	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggttttcaagtgggataagtTgtgtttttttgcactacaag	11	4	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr5:37167302T>A	uc011cpa.1	-	35	7478	c.7247A>T	c.(7246-7248)CAA>CTA	p.Q2416L	C5orf42_uc011coy.1_Missense_Mutation_p.Q916L|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.Q1491L	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2416										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGGGATAAGTTGTGTTTTTTT	0.313													A	37167302	A	A	37167302	3	1	221	1	0	0	0	0	1	0	0	0	2301	1812	63	5	2418	5	C5orf42	5	37167302	Missense_Mutation	SNP	T	TCGA-32-1970-01A-01D-1494-08		37167302	143747958	28	15436											
C7	730	broad.mit.edu	37	chr5	40976859	40976859	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatccttttttagaaaatccGttaacacaggcagtgcctaa	6	9	0	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr5:40976859G>A	uc003jmh.2	+	16	2196	c.2082G>A	c.(2080-2082)CCG>CCA	p.P694P	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	694					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				TAGAAAATCCGTTAACACAGG	0.433													A	40976859	A	A	40976859	2	1	221	1	0	0	0	0	0	0	0	1	2375	1132	40	1		1	C7	5	40976859	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08	3809557	40976859	139938401	29	15437											
ACTBL2	345651	broad.mit.edu	37	chr5	56778318	56778318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gttggtgaccactccatgctCgataggatacttcagggtca	11	10	2	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr5:56778318C>T	uc003jrm.2	-	1	319	c.217G>A	c.(217-219)GAG>AAG	p.E73K		NM_001017992	NP_001017992	Q562R1	ACTBL_HUMAN	actin, beta-like 2	73						cytoplasm|cytoskeleton	ATP binding			ovary(3)	3		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		ACTCCATGCTCGATAGGATAC	0.542													T	56778318	T	T	56778318	3	4	221	1	0	0	0	0	1	0	0	0	194	893	31	2	917	2	ACTBL2	5	56778318	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	15801459	56778318	124136942	30	15438											
GPR98	84059	broad.mit.edu	37	chr5	89990447	89990447	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaagtggcagtcgaatggcGtgttgttggtggaacagcta	15	6	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr5:89990447G>A	uc003kju.2	+	33	7970	c.7874G>A	c.(7873-7875)CGT>CAT	p.R2625H	GPR98_uc003kjt.2_Missense_Mutation_p.R331H|GPR98_uc003kjv.2_Missense_Mutation_p.R225H	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2625	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTCGAATGGCGTGTTGTTGGT	0.473													A	89990447	A	A	89990447	3	1	221	1	0	0	0	0	1	0	0	0	6721	1145	40	1	8004	1	GPR98	5	89990447	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	33212129	89990447	90924813	31	15439											
PCDHA2	56146	broad.mit.edu	37	chr5	140176747	140176747	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccaccgagggtgcgcgcgCgccaggaaagcccacgctgg	15	16	0	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr5:140176747C>T	uc003lhd.2	+	1	2304	c.2198C>T	c.(2197-2199)GCG>GTG	p.A733V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.A733V|PCDHA2_uc011czy.1_Missense_Mutation_p.A733V	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	733	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCGCGCGCGCCAGGAAAG	0.682													T	140176747	T	T	140176747	3	4	221	1	0	0	0	0	1	0	0	0	11524	768	27	1	2200	1	PCDHA2	5	140176747	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	50186300	140176747	40738513	32	15440											
PCDHGB1	56104	broad.mit.edu	37	chr5	140730079	140730079	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcggggatttgttagtgaaCggtaggatagatcgagagaa	16	3	0	3			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr5:140730079C>T	uc003ljo.1	+	1	252	c.252C>T	c.(250-252)AAC>AAT	p.N84N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Silent_p.N84N	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	84	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTAGTGAACGGTAGGATAG	0.473											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	140730079	T	T	140730079	2	4	221	1	0	0	0	0	0	0	0	1	11562	535	19	1		1	PCDHGB1	5	140730079	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	553332	140730079	40185181	33	15441											
FAM71B	153745	broad.mit.edu	37	chr5	156592869	156592869	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacctctccccttggcaaacCggccccatctgacatgctgt	8	17	2	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr5:156592869C>T	uc003lwn.2	-	1	411	c.311G>A	c.(310-312)CGG>CAG	p.R104Q		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	104						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTTGGCAAACCGGCCCCATCT	0.542													T	156592869	T	T	156592869	3	4	221	1	0	0	0	0	1	0	0	0	5608	652	23	2	1514	2	FAM71B	5	156592869	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	15862790	156592869	24322391	34	15442											
RANBP17	64901	broad.mit.edu	37	chr5	170725815	170725815	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagatgtggcagaggcgttgCgcagtgatggcaacactgaa	16	7	0	4			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr5:170725815C>T	uc003mba.2	+	28	3236	c.3220C>T	c.(3220-3222)CGC>TGC	p.R1074C	RANBP17_uc003mbb.2_Missense_Mutation_p.R399C|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	1074					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGAGGCGTTGCGCAGTGATGG	0.502			T	TRD@	ALL								T	170725815	T	T	170725815	3	4	221	1	0	0	0	0	1	0	0	0	13027	768	27	1	3330	1	RANBP17	5	170725815	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	14132946	170725815	10189445	35	15443											
FBXW11	23291	broad.mit.edu	37	chr5	171299943	171299943	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggagacaggcaatgccccGcttgtgcccattgagagtac	12	12	0	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr5:171299943G>A	uc003mbm.1	-	9	1581	c.1210C>T	c.(1210-1212)CGG>TGG	p.R404W	FBXW11_uc011dey.1_Missense_Mutation_p.R372W|FBXW11_uc003mbl.1_Missense_Mutation_p.R391W|FBXW11_uc003mbn.1_Missense_Mutation_p.R370W	NM_012300	NP_036432	Q9UKB1	FBW1B_HUMAN	F-box and WD repeat domain containing 11 isoform	404	WD 5.				cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of circadian rhythm|positive regulation of proteolysis|positive regulation of transcription, DNA-dependent|protein dephosphorylation|protein destabilization|protein polyubiquitination|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	centrosome|cytosol|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)|breast(1)	2	Renal(175;0.000159)|Lung NSC(126;0.00384)|all_lung(126;0.00659)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCAATGCCCCGCTTGTGCCCA	0.463													A	171299943	A	A	171299943	3	1	221	1	0	0	0	0	1	0	0	0	5764	1086	38	1	434	1	FBXW11	5	171299943	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	574128	171299943	9615317	36	15444											
BCLAF1	9774	broad.mit.edu	37	chr6	136597406	136597406	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcagtagcaaaacttttaccCtgatctgcgaggactgactt	9	10	1	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr6:136597406C>A	uc003qgx.1	-	5	1510	c.1257G>T	c.(1255-1257)CAG>CAT	p.Q419H	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Missense_Mutation_p.Q417H|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.Q417H	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	419					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AACTTTTACCCTGATCTGCGA	0.418													A	136597406	A	A	136597406	3	1	221	1	0	0	0	0	1	0	0	0	1383	680	24	5	1541	5	BCLAF1	6	136597406	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08		136597406	34517661	37	15445											
CDK13	8621	broad.mit.edu	37	chr7	40127783	40127783	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaagcgaagaagacagaagCagatgggcatgactgatgat	13	5	0	7			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:40127783C>T	uc003thh.3	+	12	3370	c.3088C>T	c.(3088-3090)CAG>TAG	p.Q1030*	CDK13_uc003thi.3_Nonsense_Mutation_p.Q1030*|CDK13_uc003thj.2_Nonsense_Mutation_p.Q81*	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	1030					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						AAGACAGAAGCAGATGGGCAT	0.423													T	40127783	T	T	40127783	4	4	221	1	0	0	0	0	0	1	0	0	3129	711	25	3	3134	3	CDK13	7	40127783	Nonsense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08		40127783	119010880	38	15446											
ABCA13	154664	broad.mit.edu	37	chr7	48287917	48287917	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aatatttggactggcaggaaCttgagatgcagctgtcagaa	12	6	1	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:48287917C>G	uc003toq.2	+	14	1766	c.1741C>G	c.(1741-1743)CTT>GTT	p.L581V	ABCA13_uc010kyr.2_Missense_Mutation_p.L84V	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	581					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CTGGCAGGAACTTGAGATGCA	0.428													G	48287917	G	G	48287917	3	3	221	1	0	0	0	0	1	0	0	0	31	565	20	5	1624	5	ABCA13	7	48287917	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	8160134	48287917	110850746	39	15447											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	221	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	6933905	55221822	103916841	40	15448											
PSPH	5723	broad.mit.edu	37	chr7	56088826	56088826	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gctcatcgattccttcttctCtgatgaccgtgctgtcaaca	7	13	4	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:56088826C>G	uc003trg.2	-	3	443	c.80G>C	c.(79-81)AGA>ACA	p.R27T	PSPH_uc003trh.2_Missense_Mutation_p.R27T|PSPH_uc003tri.2_Missense_Mutation_p.R27T|PSPH_uc003trj.2_Missense_Mutation_p.R56T	NM_004577	NP_004568	P78330	SERB_HUMAN	phosphoserine phosphatase	27					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCCTTCTTCTCTGATGACCGT	0.448													G	56088826	G	G	56088826	3	3	221	1	0	0	0	0	1	0	0	0	12717	913	32	5	617	5	PSPH	7	56088826	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	867004	56088826	103049837	41	15449											
ZNF735	730291	broad.mit.edu	37	chr7	63680236	63680236	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacactggagagaaaccctaCgcatgtgaagaatgtggcca	11	10	0	3			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:63680236C>T	uc011kdn.1	+	4	807	c.807C>T	c.(805-807)TAC>TAT	p.Y269Y		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	269	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGAAACCCTACGCATGTGAAG	0.458													T	63680236	T	T	63680236	2	4	221	1	0	0	0	0	0	0	0	1	18121	547	19	1		1	ZNF735	7	63680236	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	7591410	63680236	95458427	42	15450											
ZNF107	51427	broad.mit.edu	37	chr7	64167281	64167281	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggcaaggcctttaaacaggCctcacaccttactatacata	6	12	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:64167281C>A	uc003ttd.2	+	7	1385	c.599C>A	c.(598-600)GCC>GAC	p.A200D	ZNF107_uc003tte.2_Missense_Mutation_p.A200D	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	200	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TTTAAACAGGCCTCACACCTT	0.373													A	64167281	A	A	64167281	3	1	221	1	0	0	0	0	1	0	0	0	17712	739	26	5	605	5	ZNF107	7	64167281	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	487045	64167281	94971382	43	15451											
MAGI2	9863	broad.mit.edu	37	chr7	77807399	77807399	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catcctccgaagatgaacatCcaattccttataatctggac	5	12	1	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:77807399C>T	uc003ugx.2	-	14	2586	c.2332G>A	c.(2332-2334)GAT>AAT	p.D778N	MAGI2_uc003ugy.2_Missense_Mutation_p.D764N|MAGI2_uc010ldx.1_Missense_Mutation_p.D371N	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	778	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGATGAACATCCAATTCCTTA	0.453													T	77807399	T	T	77807399	3	4	221	1	0	0	0	0	1	0	0	0	9191	855	30	3	2071	3	MAGI2	7	77807399	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	13640118	77807399	81331264	44	15452											
PCLO	27445	broad.mit.edu	37	chr7	82582560	82582560	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagggatttggaaaatcttGgtgaagacttgttggagtgt	15	2	1	3			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:82582560G>A	uc003uhx.2	-	5	7998	c.7709C>T	c.(7708-7710)CCA>CTA	p.P2570L	PCLO_uc003uhv.2_Missense_Mutation_p.P2570L|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2501					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGAAAATCTTGGTGAAGACTT	0.403													A	82582560	A	A	82582560	3	1	221	1	0	0	0	0	1	0	0	0	11583	1348	47	3	7820	3	PCLO	7	82582560	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	4775161	82582560	76556103	45	15453											
GRM3	2913	broad.mit.edu	37	chr7	86416220	86416220	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacaaacgcaaccacaggcGcgtctgcgacaagcacctgg	11	14	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:86416220G>A	uc003uid.2	+	3	2211	c.1112G>A	c.(1111-1113)CGC>CAC	p.R371H	GRM3_uc010lef.2_Missense_Mutation_p.R369H|GRM3_uc010leg.2_Missense_Mutation_p.R243H|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	371	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AACCACAGGCGCGTCTGCGAC	0.567													A	86416220	A	A	86416220	3	1	221	1	0	0	0	0	1	0	0	0	6798	1087	38	1	1118	1	GRM3	7	86416220	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	3833660	86416220	72722443	46	15454											
GRM3	2913	broad.mit.edu	37	chr7	86416334	86416334	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgctttgcacaaaatgcagcGcaccctctgtcccaacacta	6	16	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:86416334G>A	uc003uid.2	+	3	2325	c.1226G>A	c.(1225-1227)CGC>CAC	p.R409H	GRM3_uc010lef.2_Missense_Mutation_p.R407H|GRM3_uc010leg.2_Missense_Mutation_p.R281H|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	409	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AAAATGCAGCGCACCCTCTGT	0.498													A	86416334	A	A	86416334	3	1	221	1	0	0	0	0	1	0	0	0	6798	1087	38	1	1232	1	GRM3	7	86416334	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	114	86416334	72722329	47	15455											
GRM3	2913	broad.mit.edu	37	chr7	86468918	86468918	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcatctgcctgggtctgatCctggtgcaaattgtgatggt	12	8	3	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:86468918C>T	uc003uid.2	+	4	3187	c.2088C>T	c.(2086-2088)ATC>ATT	p.I696I	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Silent_p.I568I|GRM3_uc010leh.2_Silent_p.I288I	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	696	Helical; Name=4; (Potential).				synaptic transmission	integral to plasma membrane		p.I696T(1)		lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGGGTCTGATCCTGGTGCAAA	0.527													T	86468918	T	T	86468918	2	4	221	1	0	0	0	0	0	0	0	1	6798	845	30	3		3	GRM3	7	86468918	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	52584	86468918	72669745	48	15456											
STEAP1	26872	broad.mit.edu	37	chr7	89791325	89791325	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggattggcaatactggctcTgttggctgtgacatctattc	12	8	2	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:89791325T>C	uc003ujx.2	+	4	895	c.695T>C	c.(694-696)CTG>CCG	p.L232P	STEAP1_uc010lem.2_Missense_Mutation_p.L232P	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	232	Ferric oxidoreductase.|Helical; (Potential).				electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					ATACTGGCTCTGTTGGCTGTG	0.378													C	89791325	C	C	89791325	3	2	221	1	0	0	0	0	1	0	0	0	15276	1580	55	4	705	4	STEAP1	7	89791325	Missense_Mutation	SNP	T	TCGA-32-1970-01A-01D-1494-08	3322407	89791325	69347338	49	15457											
TRPV5	56302	broad.mit.edu	37	chr7	142611855	142611855	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccatcagccagcagaaacGcattaggtctccaaaaatca	7	12	3	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr7:142611855G>A	uc003wby.1	-	12	1738	c.1474C>T	c.(1474-1476)CGT>TGT	p.R492C		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	492	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CAGCAGAAACGCATTAGGTCT	0.463													A	142611855	A	A	142611855	3	1	221	1	0	0	0	0	1	0	0	0	16596	1087	38	1	731	1	TRPV5	7	142611855	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	52820530	142611855	16526808	50	15458											
GATA4	2626	broad.mit.edu	37	chr8	11607623	11607623	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtttcctgtcttgcagtccGcctcccgccgagtgggcctc	11	16	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr8:11607623G>A	uc003wuc.2	+	4	1341	c.787G>A	c.(787-789)GCC>ACC	p.A263T	GATA4_uc003wub.1_Missense_Mutation_p.A57T|GATA4_uc011kxc.1_Missense_Mutation_p.A264T	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	263					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		CTTGCAGTCCGCCTCCCGCCG	0.637													A	11607623	A	A	11607623	3	1	221	1	0	0	0	0	1	0	0	0	6256	1087	38	1	797	1	GATA4	8	11607623	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08		11607623	134756399	51	15459											
ENPP2	5168	broad.mit.edu	37	chr8	120629759	120629759	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttcttcatgtatgatgcaCggaagccatccacggagaag	10	10	2	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr8:120629759C>T	uc003yot.1	-	6	610	c.524G>A	c.(523-525)CGT>CAT	p.R175H	ENPP2_uc003yos.1_Missense_Mutation_p.R175H|ENPP2_uc010mdd.1_Missense_Mutation_p.R175H	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	175					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GTATGATGCACGGAAGCCATC	0.373													T	120629759	T	T	120629759	3	4	221	1	0	0	0	0	1	0	0	0	5130	536	19	1	2386	1	ENPP2	8	120629759	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	109022136	120629759	25734263	52	15460											
BAI1	575	broad.mit.edu	37	chr8	143625027	143625027	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgaaccggaagctgcagcaCgcagcggagaaggacaagga	15	10	0	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr8:143625027C>T	uc003ywm.2	+	29	4698	c.4515C>T	c.(4513-4515)CAC>CAT	p.H1505H		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1505	Cytoplasmic (Potential).|Necessary for interaction with MAGI1.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					AGCTGCAGCACGCAGCGGAGA	0.662													T	143625027	T	T	143625027	2	4	221	1	0	0	0	0	0	0	0	1	1298	535	19	1		1	BAI1	8	143625027	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	22995268	143625027	2738995	53	15461											
OR13C9	286362	broad.mit.edu	37	chr9	107379553	107379553	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgctaaagaaccttctgttCggtaggtgttttactgcctc	9	9	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr9:107379553C>T	uc011lvr.1	-	1	933	c.933G>A	c.(931-933)CCG>CCA	p.P311P		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACCTTCTGTTCGGTAGGTGTT	0.353													T	107379553	T	T	107379553	2	4	221	1	0	0	0	0	0	0	0	1	10939	871	31	2		2	OR13C9	9	107379553	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08		107379553	33833878	54	15462											
BAT2L1	84726	broad.mit.edu	37	chr9	134350722	134350722	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaggcccggggccggggccGtggtttcagagagttcactt	16	11	2	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr9:134350722G>A	uc004can.3	+	15	3261	c.3206G>A	c.(3205-3207)CGT>CAT	p.R1069H	BAT2L1_uc010mzj.1_Missense_Mutation_p.R652H|BAT2L1_uc004cao.3_Missense_Mutation_p.R427H	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1069							protein binding				0						GGCCGGGGCCGTGGTTTCAGA	0.612													A	134350722	A	A	134350722	3	1	221	1	0	0	0	0	1	0	0	0	1320	1145	40	1	3264	1	BAT2L1	9	134350722	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	26971169	134350722	6862709	55	15463											
CEL	1056	broad.mit.edu	37	chr9	135945963	135945963	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgttttcgggaagcccttcGccacccccacgggctaccgg	11	17	0	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr9:135945963G>A	uc010naa.1	+	10	1427	c.1411G>A	c.(1411-1413)GCC>ACC	p.A471T		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	468					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GAAGCCCTTCGCCACCCCCAC	0.582													A	135945963	A	A	135945963	3	1	221	1	0	0	0	0	1	0	0	0	3209	1087	38	1	1449	1	CEL	9	135945963	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	1595241	135945963	5267468	56	15464											
ITIH5	80760	broad.mit.edu	37	chr10	7605143	7605143	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccgtcaatcagtttggcgGcattgttcctggcaaaccag	10	13	2	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr10:7605143G>A	uc001ijq.2	-	14	2811	c.2732C>T	c.(2731-2733)GCC>GTC	p.A911V	ITIH5_uc001ijp.2_Missense_Mutation_p.A697V	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	911					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CAGTTTGGCGGCATTGTTCCT	0.522													A	7605143	A	A	7605143	3	1	221	1	0	0	0	0	1	0	0	0	7907	1203	42	3	142	3	ITIH5	10	7605143	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08		7605143	127929604	57	15465											
ITIH5	80760	broad.mit.edu	37	chr10	7659109	7659109	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atgctctgttctctattgacGtcatatctaatgataaagtc	6	8	4	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr10:7659109G>T	uc001ijq.2	-	6	868	c.789C>A	c.(787-789)GAC>GAA	p.D263E	ITIH5_uc001ijp.2_Missense_Mutation_p.D49E|ITIH5_uc001ijr.1_Missense_Mutation_p.D263E	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	263					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						CTCTATTGACGTCATATCTAA	0.388													T	7659109	T	T	7659109	3	4	221	1	0	0	0	0	1	0	0	0	7907	1136	40	5	2198	5	ITIH5	10	7659109	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	53966	7659109	127875638	58	15466											
CYP2C18	1562	broad.mit.edu	37	chr10	96447617	96447617	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaagcagtgaaggaggccCtgattgatcatggagaggag	16	5	1	5			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr10:96447617C>T	uc001kjv.3	+	2	585	c.259C>T	c.(259-261)CTG>TTG	p.L87L	CYP2C18_uc001kjw.3_Silent_p.L87L|CYP2C19_uc009xus.1_5'Flank|CYP2C19_uc010qny.1_5'Flank	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	87					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GAAGGAGGCCCTGATTGATCA	0.433													T	96447617	T	T	96447617	2	4	221	1	0	0	0	0	0	0	0	1	4165	680	24	3		3	CYP2C18	10	96447617	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	88788508	96447617	39087130	59	15467											
SOX6	55553	broad.mit.edu	37	chr11	16007846	16007846	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccatcaacaatgcaggtgCgtttcggtcggggtttgtat	13	8	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:16007846C>T	uc001mme.2	-	15	2159	c.2126G>A	c.(2125-2127)CGC>CAC	p.R709H	SOX6_uc001mmd.2_Missense_Mutation_p.R672H|SOX6_uc001mmf.2_Missense_Mutation_p.R669H|SOX6_uc001mmg.2_Missense_Mutation_p.R676H	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	696					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						AATGCAGGTGCGTTTCGGTCG	0.473													T	16007846	T	T	16007846	3	4	221	1	0	0	0	0	1	0	0	0	14955	768	27	1	407	1	SOX6	11	16007846	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08		16007846	118998670	60	15468											
MRGPRX3	117195	broad.mit.edu	37	chr11	18158842	18158842	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcagaccctgagcttcacGgggctgacgtgcatcgtttc	12	12	1	3			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:18158842G>A	uc001mnu.2	+	3	454	c.93G>A	c.(91-93)ACG>ACA	p.T31T		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	31	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						TGAGCTTCACGGGGCTGACGT	0.567													A	18158842	A	A	18158842	2	1	221	1	0	0	0	0	0	0	0	1	9768	1103	39	2		2	MRGPRX3	11	18158842	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08	2150996	18158842	116847674	61	15469											
MYBPC3	4607	broad.mit.edu	37	chr11	47360181	47360181	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcgaccgtgaagatgctgCggtccttggtggtctccacg	13	13	1	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:47360181C>T	uc001nfa.3	-	22	2253	c.2198G>A	c.(2197-2199)CGC>CAC	p.R733H	MYBPC3_uc010rhl.1_RNA	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	732	Ig-like C2-type 5.		R -> C (in CMH4).		cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		GAAGATGCTGCGGTCCTTGGT	0.632													T	47360181	T	T	47360181	3	4	221	1	0	0	0	0	1	0	0	0	10013	768	27	1	1674	1	MYBPC3	11	47360181	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	29201339	47360181	87646335	62	15470											
OR4B1	119765	broad.mit.edu	37	chr11	48238965	48238965	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttattgtgttggccaacagtGgattattctctgtcttctcc	8	9	3	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:48238965G>A	uc010rhs.1	+	1	604	c.604G>A	c.(604-606)GGA>AGA	p.G202R		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						GGCCAACAGTGGATTATTCTC	0.473													A	48238965	A	A	48238965	3	1	221	1	0	0	0	0	1	0	0	0	11044	1349	47	3	606	3	OR4B1	11	48238965	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	878784	48238965	86767551	63	15471											
RTN4RL2	349667	broad.mit.edu	37	chr11	57235097	57235097	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cacagctcccgcctcggcctGcctcctgctgatgctcctgg	10	19	0	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:57235097G>C	uc010rjt.1	+	2	47	c.47G>C	c.(46-48)TGC>TCC	p.C16S		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	16					axon regeneration	anchored to plasma membrane	receptor activity				0						GCCTCGGCCTGCCTCCTGCTG	0.682													C	57235097	C	C	57235097	3	2	221	1	0	0	0	0	1	0	0	0	13732	1319	46	5	53	5	RTN4RL2	11	57235097	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	8996132	57235097	77771419	64	15472											
OR1S1	219959	broad.mit.edu	37	chr11	57982381	57982381	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggtcactgtgattgggaaCgggctcatcattgtggctat	13	8	3	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:57982381C>T	uc010rkc.1	+	1	165	c.165C>T	c.(163-165)AAC>AAT	p.N55N		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	55	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				TGATTGGGAACGGGCTCATCA	0.443													T	57982381	T	T	57982381	2	4	221	1	0	0	0	0	0	0	0	1	10972	535	19	1		1	OR1S1	11	57982381	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	747284	57982381	77024135	65	15473											
MS4A3	932	broad.mit.edu	37	chr11	59837091	59837091	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaccttgctggaattatgCgtaaccatctctaccatagc	6	13	2	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:59837091C>T	uc001nom.2	+	6	686	c.558C>T	c.(556-558)TGC>TGT	p.C186C	MS4A3_uc001non.2_Silent_p.C140C|MS4A3_uc001noo.2_Silent_p.C63C	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	186	Helical; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				TGGAATTATGCGTAACCATCT	0.413													T	59837091	T	T	59837091	2	4	221	1	0	0	0	0	0	0	0	1	9861	776	27	1		1	MS4A3	11	59837091	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	1854710	59837091	75169425	66	15474											
POLD4	57804	broad.mit.edu	37	chr11	67120265	67120265	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgacaccagcgctgcagccGtgtgatccctgccagggtgg	14	15	0	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:67120265G>A	uc001okm.2	-	3	343	c.196C>T	c.(196-198)CGG>TGG	p.R66W	LOC100130987_uc010rpo.1_Intron|POLD4_uc001okn.2_RNA|POLD4_uc001oko.2_RNA|POLD4_uc001okp.1_3'UTR	NM_021173	NP_066996	Q9HCU8	DPOD4_HUMAN	DNA-directed DNA polymerase delta 4	66					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA-directed DNA polymerase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(15;3.08e-06)			CGCTGCAGCCGTGTGATCCCT	0.637													A	67120265	A	A	67120265	3	1	221	1	0	0	0	0	1	0	0	0	12193	1144	40	1	135	1	POLD4	11	67120265	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	7283174	67120265	67886251	67	15475											
MTNR1B	4544	broad.mit.edu	37	chr11	92714860	92714860	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atctaccggcgctggcacacCcctctgcacatctgcctcat	7	18	4	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:92714860C>A	uc001pdk.1	+	2	574	c.471C>A	c.(469-471)ACC>ACA	p.T157T		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	157	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GCTGGCACACCCCTCTGCACA	0.572													A	92714860	A	A	92714860	2	1	221	1	0	0	0	0	0	0	0	1	9952	610	22	5		5	MTNR1B	11	92714860	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	25594595	92714860	42291656	68	15476											
CWF19L2	143884	broad.mit.edu	37	chr11	107200691	107200691	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgatcttcaatgacatgggCaaaccctccgtgaaggccaa	9	12	2	3			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr11:107200691C>T	uc010rvp.1	-	17	2524	c.2494G>A	c.(2494-2496)GCC>ACC	p.A832T	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	832							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		ATGACATGGGCAAACCCTCCG	0.383													T	107200691	T	T	107200691	3	4	221	1	0	0	0	0	1	0	0	0	4072	710	25	3	198	3	CWF19L2	11	107200691	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	14485831	107200691	27805825	69	15477											
PRPF40B	25766	broad.mit.edu	37	chr12	50030600	50030600	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcccggcttcgggagcgaCgccaacaacgcaagaatcgg	15	13	0	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr12:50030600C>T	uc001rur.1	+	15	1526	c.1462C>T	c.(1462-1464)CGC>TGC	p.R488C	PRPF40B_uc001rup.1_Missense_Mutation_p.R510C|PRPF40B_uc001ruq.1_Missense_Mutation_p.R482C|PRPF40B_uc001rus.1_Missense_Mutation_p.R431C	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	488					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						TCGGGAGCGACGCCAACAACG	0.562											OREG0021797	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	50030600	T	T	50030600	3	4	221	1	0	0	0	0	1	0	0	0	12572	536	19	1	1520	1	PRPF40B	12	50030600	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08		50030600	83821295	70	15478											
CELA1	1990	broad.mit.edu	37	chr12	51723540	51723540	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggagacattacagccccgGctggacacaaagctggtcac	11	13	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr12:51723540G>A	uc001ryi.1	-	7	728	c.687C>T	c.(685-687)AGC>AGT	p.S229S		NM_001971	NP_001962	Q9UNI1	CELA1_HUMAN	chymotrypsin-like elastase family, member 1	229	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			breast(1)	1						TACAGCCCCGGCTGGACACAA	0.512													A	51723540	A	A	51723540	2	1	221	1	0	0	0	0	0	0	0	1	3210	1194	42	3		3	CELA1	12	51723540	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08	1692940	51723540	82128355	71	15479											
STAT2	6773	broad.mit.edu	37	chr12	56748251	56748251	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttggggtggtacctctcaccAtgtctccagctgttccaacc	9	14	2	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr12:56748251A>G	uc001slc.2	-	8	859	c.781T>C	c.(781-783)TGG>CGG	p.W261R	STAT2_uc001sld.2_Missense_Mutation_p.W257R|STAT2_uc010sqn.1_Missense_Mutation_p.W257R	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	261					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						ACCTCTCACCATGTCTCCAGC	0.527													G	56748251	G	G	56748251	3	3	221	1	0	0	0	0	1	0	0	0	15264	231	8	4	1842	4	STAT2	12	56748251	Missense_Mutation	SNP	A	TCGA-32-1970-01A-01D-1494-08	5024711	56748251	77103644	72	15480											
UTP20	27340	broad.mit.edu	37	chr12	101750729	101750729	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgctgaaagtgtgtgccctaCtcaagaacagagcccaagaa	10	10	1	4			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr12:101750729C>A	uc001tia.1	+	43	5716	c.5560C>A	c.(5560-5562)CTC>ATC	p.L1854I		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1854	HEAT 2.				endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GTGTGCCCTACTCAAGAACAG	0.363													A	101750729	A	A	101750729	3	1	221	1	0	0	0	0	1	0	0	0	17096	565	20	5	5730	5	UTP20	12	101750729	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	45002478	101750729	32101166	73	15481											
TMEM132B	114795	broad.mit.edu	37	chr12	125834519	125834519	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgagctggagctgctgcccGagtggttcagctcaggcctg	15	12	2	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr12:125834519G>A	uc001uhe.1	+	2	582	c.574G>A	c.(574-576)GAG>AAG	p.E192K		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	192	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GCTGCTGCCCGAGTGGTTCAG	0.632													A	125834519	A	A	125834519	3	1	221	1	0	0	0	0	1	0	0	0	16043	1059	37	2	580	2	TMEM132B	12	125834519	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	24083790	125834519	8017376	74	15482											
RB1	5925	broad.mit.edu	37	chr13	49039351	49039351	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttgctctagccccctacctTgtcaccaatacctcacattc	3	17	3	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr13:49039351T>A	uc001vcb.2	+	23	2502	c.2336T>A	c.(2335-2337)TTG>TAG	p.L779*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	779	Interaction with LIMD1.|Domain C; mediates interaction with E4F1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCCCCTACCTTGTCACCAATA	0.398		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			A	49039351	A	A	49039351	4	1	221	1	0	0	0	0	0	1	0	0	13098	1821	63	5	2426	5	RB1	13	49039351	Nonsense_Mutation	SNP	T	TCGA-32-1970-01A-01D-1494-08		49039351	66130527	75	15483											
FGF14	2259	broad.mit.edu	37	chr13	102375254	102375254	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacttgtgcttttacttggcGtcaccccaggcttcgggacc	10	14	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr13:102375254G>A	uc001vpe.2	-	5	671	c.671C>T	c.(670-672)ACG>ATG	p.T224M	FGF14_uc001vpf.2_Missense_Mutation_p.T229M|FGF14_uc001vpd.1_5'Flank	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	224					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTTACTTGGCGTCACCCCAGG	0.473													A	102375254	A	A	102375254	3	1	221	1	0	0	0	0	1	0	0	0	5843	1145	40	1	76	1	FGF14	13	102375254	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	53335903	102375254	12794624	76	15484											
RNF31	55072	broad.mit.edu	37	chr14	24627141	24627141	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	taactgcagggtgaaaaagtCcctgcacggccaccaccctc	9	15	0	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr14:24627141C>A	uc001wmn.1	+	17	3011	c.2762C>A	c.(2761-2763)TCC>TAC	p.S921Y	RNF31_uc001wml.1_Missense_Mutation_p.S770Y|RNF31_uc010alg.1_Missense_Mutation_p.S680Y|RNF31_uc001wmo.1_Missense_Mutation_p.S388Y|RNF31_uc001wmp.2_RNA|RNF31_uc010alh.1_Missense_Mutation_p.S105Y	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	921	IBR-type 2.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GTGAAAAAGTCCCTGCACGGC	0.587													A	24627141	A	A	24627141	3	1	221	1	0	0	0	0	1	0	0	0	13487	855	30	5	2828	5	RNF31	14	24627141	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08		24627141	82722399	77	15485											
C14orf145	145508	broad.mit.edu	37	chr14	81329142	81329142	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtcccagttgatcctggcGtctttccaccagctcccttt	8	15	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr14:81329142G>A	uc001xux.2	-	8	892	c.721C>T	c.(721-723)CGC>TGC	p.R241C	C14orf145_uc001xuz.2_Missense_Mutation_p.R241C|C14orf145_uc001xuy.1_Missense_Mutation_p.R99C	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	241	Potential.					centriole|spindle pole		p.R241C(1)			0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		TGATCCTGGCGTCTTTCCACC	0.463													A	81329142	A	A	81329142	3	1	221	1	0	0	0	0	1	0	0	0	1749	1145	40	1	2631	1	C14orf145	14	81329142	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	56702001	81329142	26020398	78	15486											
FLRT2	23768	broad.mit.edu	37	chr14	86088466	86088466	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgacatggccttccagaatcTcacgagcttggagcgtctta	10	12	2	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr14:86088466T>C	uc001xvr.2	+	2	1375	c.608T>C	c.(607-609)CTC>CCC	p.L203P	FLRT2_uc010atd.2_Missense_Mutation_p.L203P	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	203	Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TTCCAGAATCTCACGAGCTTG	0.522													C	86088466	C	C	86088466	3	2	221	1	0	0	0	0	1	0	0	0	5939	1551	54	4	610	4	FLRT2	14	86088466	Missense_Mutation	SNP	T	TCGA-32-1970-01A-01D-1494-08	4759324	86088466	21261074	79	15487											
GATM	2628	broad.mit.edu	37	chr15	45668979	45668979	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gtagctgcctgggtgctctgGaaagttcgctgcacccatcc	12	13	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr15:45668979G>T	uc001zvc.2	-	2	437	c.108C>A	c.(106-108)TTC>TTA	p.F36L	GATM_uc001zvb.2_5'UTR|GATM_uc010uev.1_Missense_Mutation_p.F89L	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	36					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	GGGTGCTCTGGAAAGTTCGCT	0.512													T	45668979	T	T	45668979	3	4	221	1	0	0	0	0	1	0	0	0	6263	1165	41	5	1195	5	GATM	15	45668979	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08		45668979	56862413	80	15488											
MEGF11	84465	broad.mit.edu	37	chr15	66191203	66191203	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggatgggtgggtccttaattGtggcgtaagggttttcactg	16	5	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr15:66191203G>T	uc002apm.2	-	22	2978	c.2837C>A	c.(2836-2838)ACA>AAA	p.T946K	MEGF11_uc002apl.2_Missense_Mutation_p.T871K|MEGF11_uc002apn.1_Missense_Mutation_p.T946K	NM_032445	NP_115821	A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11 precursor	946						basolateral plasma membrane|integral to membrane				pancreas(1)	1						GTCCTTAATTGTGGCGTAAGG	0.468													T	66191203	T	T	66191203	3	4	221	1	0	0	0	0	1	0	0	0	9461	1377	48	5	305	5	MEGF11	15	66191203	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	20522224	66191203	36340189	81	15489											
PGPEP1L	145814	broad.mit.edu	37	chr15	99512679	99512679	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcatctcgggaaaagatcaCgtcgacaccctccacagcta	8	14	2	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr15:99512679C>T	uc002bum.2	-	4	552	c.346G>A	c.(346-348)GTG>ATG	p.V116M	PGPEP1L_uc010bop.2_Missense_Mutation_p.V62M|PGPEP1L_uc002bun.2_RNA	NM_001102612	NP_001096082	A6NFU8	PGPIL_HUMAN	pyroglutamyl-peptidase 1-like protein	116					proteolysis		cysteine-type peptidase activity				0						GAAAAGATCACGTCGACACCC	0.627													T	99512679	T	T	99512679	3	4	221	1	0	0	0	0	1	0	0	0	11804	536	19	1	252	1	PGPEP1L	15	99512679	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	33321476	99512679	3018713	82	15490											
TMEM219	124446	broad.mit.edu	37	chr16	29979390	29979390	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttatcacagccagggtgaccAcagaaaggactgcaggaacc	11	11	1	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr16:29979390A>G	uc002duw.2	+	4	567	c.400A>G	c.(400-402)ACA>GCA	p.T134A	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TMEM219_uc002duy.2_Missense_Mutation_p.T134A|TMEM219_uc010bzk.1_Missense_Mutation_p.T134A|TMEM219_uc002duz.2_Missense_Mutation_p.T134A|TMEM219_uc010bzl.1_RNA	NM_194280	NP_919256	Q86XT9	TM219_HUMAN	transmembrane protein 219	134						integral to membrane					0						CAGGGTGACCACAGAAAGGAC	0.527													G	29979390	G	G	29979390	3	3	221	1	0	0	0	0	1	0	0	0	16139	159	6	4	410	4	TMEM219	16	29979390	Missense_Mutation	SNP	A	TCGA-32-1970-01A-01D-1494-08		29979390	60375363	83	15491											
SNX20	124460	broad.mit.edu	37	chr16	50707501	50707501	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccctcccgggcctgcaggCgctgcagggccctctctccg	14	19	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr16:50707501C>T	uc002egk.2	-	4	940	c.767G>A	c.(766-768)CGC>CAC	p.R256H	SNX20_uc010vgp.1_Intron|SNX20_uc002egi.3_Intron	NM_182854	NP_878274	Q7Z614	SNX20_HUMAN	sorting nexin 20 isoform 1	256					cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			ovary(1)	1						GGCCTGCAGGCGCTGCAGGGC	0.741													T	50707501	T	T	50707501	3	4	221	1	0	0	0	0	1	0	0	0	14892	768	27	1	330	1	SNX20	16	50707501	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	20728111	50707501	39647252	84	15492											
CPNE2	221184	broad.mit.edu	37	chr16	57153520	57153520	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaagccattcacagtgccCttggtgtccctgtgtgatgg	13	10	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr16:57153520C>T	uc002eks.1	+	7	868	c.639C>T	c.(637-639)CCC>CCT	p.P213P	CPNE2_uc010cct.1_Silent_p.P239P|CPNE2_uc010ccu.1_Silent_p.P213P	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	213	C2 2.									central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				TCACAGTGCCCTTGGTGTCCC	0.617													T	57153520	T	T	57153520	2	4	221	1	0	0	0	0	0	0	0	1	3812	668	24	3		3	CPNE2	16	57153520	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	6446019	57153520	33201233	85	15493											
PKD1L2	114780	broad.mit.edu	37	chr16	81181065	81181065	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgagtcccagcccaaggCgggggatggcaccttgagag	15	12	0	2	rs113696594		TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr16:81181065C>T	uc002fgh.1	-	30	5026	c.5026G>A	c.(5026-5028)GCC>ACC	p.A1676T	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1676	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAGCCCAAGGCGGGGGATGGC	0.512													T	81181065	T	T	81181065	3	4	221	1	0	0	0	0	1	0	0	0	11965	768	27	1	2408	1	PKD1L2	16	81181065	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	24027545	81181065	9173688	86	15494											
NEURL4	84461	broad.mit.edu	37	chr17	7220634	7220634	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagttctcgccaggctcctcGaaccctaccccaggttctcc	7	19	2	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr17:7220634G>A	uc002gga.1	-	28	4381	c.4374C>T	c.(4372-4374)TTC>TTT	p.F1458F	GPS2_uc002gfv.1_5'Flank|GPS2_uc002gfw.1_5'Flank|GPS2_uc002gfx.1_5'Flank|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_5'UTR|NEURL4_uc002ggb.1_Silent_p.F1456F	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	1458							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						CAGGCTCCTCGAACCCTACCC	0.607													A	7220634	A	A	7220634	2	1	221	1	0	0	0	0	0	0	0	1	10347	1049	37	2		2	NEURL4	17	7220634	Silent	SNP	G	TCGA-32-1970-01A-01D-1494-08		7220634	73974576	87	15495											
TP53	7157	broad.mit.edu	37	chr17	7577138	7577138	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cacgcacctcaaagctgttcCgtcccagtagattaccacta	6	15	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr17:7577138C>G	uc002gim.2	-	8	994	c.800G>C	c.(799-801)CGG>CCG	p.R267P	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R267P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R135P|TP53_uc010cng.1_Missense_Mutation_p.R135P|TP53_uc002gii.1_Missense_Mutation_p.R135P|TP53_uc010cnh.1_Missense_Mutation_p.R267P|TP53_uc010cni.1_Missense_Mutation_p.R267P|TP53_uc002gij.2_Missense_Mutation_p.R267P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	267	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> H (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R267W(20)|p.R267P(13)|p.0?(7)|p.R267Q(7)|p.R267R(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.R267fs*78(1)|p.N268fs*77(1)|p.L265_K305del41(1)|p.R267G(1)|p.E258fs*71(1)|p.L265_R267delLGR(1)|p.R267L(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAAGCTGTTCCGTCCCAGTAG	0.527		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			G	7577138	G	G	7577138	3	3	221	1	0	0	0	0	1	0	0	0	16378	652	23	5	486	5	TP53	17	7577138	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	356504	7577138	73618072	88	15496											
SLC47A2	146802	broad.mit.edu	37	chr17	19618087	19618087	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accaactcctacagaaactcCgcagacattgacaaactggc	6	14	0	3	rs148775490	byFrequency	TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr17:19618087C>T	uc002gwe.3	-	3	416	c.241G>A	c.(241-243)GGA>AGA	p.G81R	SLC47A2_uc002gwg.3_Missense_Mutation_p.G81R|SLC47A2_uc002gwf.3_Missense_Mutation_p.G81R|SLC47A2_uc002gwh.3_RNA|SLC47A2_uc002gwi.2_RNA|SLC47A2_uc010cqs.1_RNA|SLC47A2_uc010cqt.1_RNA	NM_152908	NP_690872	Q86VL8	S47A2_HUMAN	solute carrier family 47, member 2 isoform 1	81	Helical; (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					ACAGAAACTCCGCAGACATTG	0.587													T	19618087	T	T	19618087	3	4	221	1	0	0	0	0	1	0	0	0	14648	661	23	2	1627	2	SLC47A2	17	19618087	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	12040949	19618087	61577123	89	15497											
DHRS13	147015	broad.mit.edu	37	chr17	27228288	27228288	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccgaagcagcaggttaaaCgcctcacgggtccggccaca	11	15	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr17:27228288C>T	uc002hde.3	-	4	529	c.402G>A	c.(400-402)GCG>GCA	p.A134A	DHRS13_uc002hdd.3_Silent_p.A84A|DHRS13_uc010wba.1_Silent_p.A53A	NM_144683	NP_653284	Q6UX07	DHR13_HUMAN	dehydrogenase/reductase (SDR family) member 13	134						extracellular region	binding|oxidoreductase activity				0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.59e-06)|all cancers(11;9.27e-06)|BRCA - Breast invasive adenocarcinoma(11;5.78e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			GCAGGTTAAACGCCTCACGGG	0.592													T	27228288	T	T	27228288	2	4	221	1	0	0	0	0	0	0	0	1	4489	523	19	1		1	DHRS13	17	27228288	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08	7610201	27228288	53966922	90	15498											
AXIN2	8313	broad.mit.edu	37	chr17	63553948	63553948	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccactgtcaacagtttccGtggacctcacactcgccgtg	8	15	2	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr17:63553948G>A	uc002jfi.2	-	2	1080	c.791C>T	c.(790-792)ACG>ATG	p.T264M	AXIN2_uc010den.1_Missense_Mutation_p.T264M|AXIN2_uc002jfh.2_Missense_Mutation_p.T264M|AXIN2_uc002jfj.1_Missense_Mutation_p.T264M	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	264					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						AACAGTTTCCGTGGACCTCAC	0.537									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				A	63553948	A	A	63553948	3	1	221	1	0	0	0	0	1	0	0	0	1237	1145	40	1	1780	1	AXIN2	17	63553948	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	36325660	63553948	17641262	91	15499											
EMR3	84658	broad.mit.edu	37	chr19	14785604	14785604	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgtggtacgggtatcccaCgccagccagccctggaagct	12	14	1	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr19:14785604C>T	uc002mzi.3	-	1	127	c.-21G>A	c.(-23--19)GCGTG>GCATG		EMR3_uc010dzp.2_Translation_Start_Site|EMR3_uc010xnv.1_Translation_Start_Site	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor						neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						GGGTATCCCACGCCAGCCAGC	0.507													T	14785604	T	T	14785604	1	4	221	1	0	0	0	0	0	0	0	0	5106	551	19	1		1	EMR3	19	14785604	Translation_Start_Site	SNP	C	TCGA-32-1970-01A-01D-1494-08		14785604	44343379	92	15500											
F2RL3	9002	broad.mit.edu	37	chr19	17000950	17000950	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctggcgcgctccgatcgcGtgctctgccatgacgcgctg	15	15	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr19:17000950G>A	uc002nfa.2	+	2	851	c.676G>A	c.(676-678)GTG>ATG	p.V226M		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	226	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						CTCCGATCGCGTGCTCTGCCA	0.701													A	17000950	A	A	17000950	3	1	221	1	0	0	0	0	1	0	0	0	5346	1145	40	1	682	1	F2RL3	19	17000950	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	2215346	17000950	42128033	93	15501											
FFAR3	2865	broad.mit.edu	37	chr19	35849928	35849928	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgtgggcaagctgcagcgcCgcccggtggccgtggacgtg	18	13	0	0			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr19:35849928C>T	uc002nzd.2	+	2	211	c.136C>T	c.(136-138)CGC>TGC	p.R46C	FFAR3_uc010xsu.1_RNA	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	46	Cytoplasmic.					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			GCTGCAGCGCCGCCCGGTGGC	0.637													T	35849928	T	T	35849928	3	4	221	1	0	0	0	0	1	0	0	0	5829	652	23	2	138	2	FFAR3	19	35849928	Missense_Mutation	SNP	C	TCGA-32-1970-01A-01D-1494-08	18848978	35849928	23279055	94	15502											
ZNF229	7772	broad.mit.edu	37	chr19	44932920	44932920	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtatagggcttttttcccGtgtggactcgctgatgtttg	12	8	0	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr19:44932920G>A	uc002oze.1	-	6	2470	c.2036C>T	c.(2035-2037)ACG>ATG	p.T679M	ZNF229_uc010ejk.1_Missense_Mutation_p.T333M|ZNF229_uc010ejl.1_Missense_Mutation_p.T673M	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	679					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				CTTTTTTCCCGTGTGGACTCG	0.512													A	44932920	A	A	44932920	3	1	221	1	0	0	0	0	1	0	0	0	17779	1145	40	1	445	1	ZNF229	19	44932920	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	9082992	44932920	14196063	95	15503											
ZNFX1	57169	broad.mit.edu	37	chr20	47887010	47887010	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaagacccatagagcaatcGtttggaattctgccagcgaa	9	10	1	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr20:47887010G>A	uc002xui.2	-	3	1586	c.1339C>T	c.(1339-1341)CGA>TGA	p.R447*		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	447							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TAGAGCAATCGTTTGGAATTC	0.468													A	47887010	A	A	47887010	4	1	221	1	0	0	0	0	0	1	0	0	18202	1153	40	1	4465	1	ZNFX1	20	47887010	Nonsense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08		47887010	15138510	96	15504											
PRIC285	85441	broad.mit.edu	37	chr20	62200284	62200284	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtacagtgctcccggaggcGcgaagagcatgttcagcgct	14	12	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr20:62200284G>A	uc002yfm.2	-	6	2049	c.1157C>T	c.(1156-1158)GCG>GTG	p.A386V	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	386					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TCCCGGAGGCGCGAAGAGCAT	0.677													A	62200284	A	A	62200284	3	1	221	1	0	0	0	0	1	0	0	0	12485	1087	38	1	6875	1	PRIC285	20	62200284	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08	14313274	62200284	825236	97	15505											
CYTSA	23384	broad.mit.edu	37	chr22	24807598	24807598	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcagctggaatgatgggCtggccttctgtgccctcctg	14	12	1	1			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chr22:24807598C>T	uc002zzw.2	+	15	3437	c.3130C>T	c.(3130-3132)CTG>TTG	p.L1044L	CYTSA_uc002zzv.3_Silent_p.L1044L|CYTSA_uc011ajq.1_Intron	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	1044	CH.				cell cycle|cell division						0						GAATGATGGGCTGGCCTTCTG	0.493													T	24807598	T	T	24807598	2	4	221	1	0	0	0	0	0	0	0	1	4209	796	28	3		3	CYTSA	22	24807598	Silent	SNP	C	TCGA-32-1970-01A-01D-1494-08		24807598	26496968	98	15506											
EGFL6	25975	broad.mit.edu	37	chrX	13624543	13624543	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtcatctgtccctacaatcGaagatgtgtgaacacatttg	8	9	2	2			TCGA-32-1970-01A-01D-1494-08	TCGA-32-1970-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	65723119-bdfe-46f0-b629-c171023abd71	5b9d2db6-f2b7-47b8-8105-ba44ff3274b7	g.chrX:13624543G>A	uc004cvi.2	+	6	806	c.566G>A	c.(565-567)CGA>CAA	p.R189Q	EGFL6_uc004cvj.2_Missense_Mutation_p.R189Q|EGFL6_uc011mik.1_Missense_Mutation_p.R90Q	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	189	EGF-like 4; calcium-binding (Potential).				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						CCCTACAATCGAAGATGTGTG	0.398													A	13624543	A	A	13624543	3	1	221	1	0	0	0	0	1	0	0	0	4963	1058	37	2	588	2	EGFL6	23	13624543	Missense_Mutation	SNP	G	TCGA-32-1970-01A-01D-1494-08		13624543	141646017	99	15507											
PLEKHN1	84069	broad.mit.edu	37	chr1	909247	909247	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagagtgcacgtggacccaCgccctcgagcccactcccct	10	19	0	1	rs72631892	by1000genomes	TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr1:909247C>T	uc001ace.2	+	13	1660	c.1625C>T	c.(1624-1626)ACG>ATG	p.T542M	PLEKHN1_uc001acd.2_Missense_Mutation_p.T490M|PLEKHN1_uc001acf.2_Missense_Mutation_p.T455M	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	542											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CGTGGACCCACGCCCTCGAGC	0.682													T	909247	T	T	909247	3	4	222	1	0	0	0	0	1	0	0	0	12083	536	19	1	1559	1	PLEKHN1	1	909247	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08		909247	248341374	1	15508											
TAS1R2	80834	broad.mit.edu	37	chr1	19168299	19168299	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	acgtggatgcccacaggcttCttcttttgccctgactggca	10	13	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr1:19168299C>T	uc001bba.1	-	5	1516	c.1515G>A	c.(1513-1515)AAG>AAA	p.K505K		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	505	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CCACAGGCTTCTTCTTTTGCC	0.557													T	19168299	T	T	19168299	2	4	222	1	0	0	0	0	0	0	0	1	15560	912	32	3		3	TAS1R2	1	19168299	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08	18259052	19168299	230082322	2	15509											
RIMS3	9783	broad.mit.edu	37	chr1	41107474	41107474	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgctccgccgcttcttggCggtggtggtcccagccccgc	14	17	1	0	rs149583022		TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr1:41107474C>T	uc001cfu.1	-	3	593	c.124G>A	c.(124-126)GCC>ACC	p.A42T	RIMS3_uc001cfv.1_Missense_Mutation_p.A42T	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	42					neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			CGCTTCTTGGCGGTGGTGGTC	0.657													T	41107474	T	T	41107474	3	4	222	1	0	0	0	0	1	0	0	0	13369	768	27	1	826	1	RIMS3	1	41107474	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	21939175	41107474	208143147	3	15510											
PTPRF	5792	broad.mit.edu	37	chr1	44069550	44069550	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagttcgagaaggagatcagGacccccgaggacctgcccag	14	12	1	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr1:44069550G>A	uc001cjr.2	+	16	3067	c.2727G>A	c.(2725-2727)AGG>AGA	p.R909R	PTPRF_uc001cjs.2_Silent_p.R900R|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Silent_p.R469R|PTPRF_uc001cjv.2_Silent_p.R369R|PTPRF_uc001cjw.2_Silent_p.R135R	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	909	Extracellular (Potential).|Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGGAGATCAGGACCCCCGAGG	0.627													A	44069550	A	A	44069550	2	1	222	1	0	0	0	0	0	0	0	1	12801	1165	41	3		3	PTPRF	1	44069550	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	2962076	44069550	205181071	4	15511											
WLS	79971	broad.mit.edu	37	chr1	68603590	68603590	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcacttggactgtgacgccGccccatttccaatggccttc	8	15	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr1:68603590G>A	uc001def.1	-	11	1660	c.1389C>T	c.(1387-1389)GGC>GGT	p.G463G	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Silent_p.G461G|WLS_uc001deg.1_Silent_p.G372G|WLS_uc009wbf.1_Silent_p.G418G	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	463	Lumenal (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						CTGTGACGCCGCCCCATTTCC	0.443													A	68603590	A	A	68603590	2	1	222	1	0	0	0	0	0	0	0	1	17373	1074	38	1		1	WLS	1	68603590	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	24534040	68603590	180647031	5	15512											
ATP1A1	476	broad.mit.edu	37	chr1	116943788	116943788	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatcgtggagttcacctgcCacacagccttcttcgtcagt	8	13	3	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr1:116943788C>T	uc001ege.2	+	20	3094	c.2755C>T	c.(2755-2757)CAC>TAC	p.H919Y	ATP1A1_uc010owv.1_Missense_Mutation_p.H888Y|ATP1A1_uc010oww.1_Missense_Mutation_p.H919Y|ATP1A1_uc010owx.1_Missense_Mutation_p.H888Y|C1orf203_uc009whb.2_Intron|C1orf203_uc001egg.3_Intron|ATP1A1_uc001egh.2_Missense_Mutation_p.H61Y	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	919	Helical; (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	GTTCACCTGCCACACAGCCTT	0.532													T	116943788	T	T	116943788	3	4	222	1	0	0	0	0	1	0	0	0	1128	594	21	3	2849	3	ATP1A1	1	116943788	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	48340198	116943788	132306833	6	15513											
TBX15	6913	broad.mit.edu	37	chr1	119441665	119441665	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctttaccttgctgcttctgcAtggtggtgaagtcttcgaag	11	9	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr1:119441665A>G	uc001ehl.1	-	7	1007	c.692T>C	c.(691-693)ATG>ACG	p.M231T	TBX15_uc009whj.1_Missense_Mutation_p.M22T	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	337						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CTGCTTCTGCATGGTGGTGAA	0.527													G	119441665	G	G	119441665	3	3	222	1	0	0	0	0	1	0	0	0	15649	217	8	4	806	4	TBX15	1	119441665	Missense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	2497877	119441665	129808956	7	15514											
SV2A	9900	broad.mit.edu	37	chr1	149885276	149885276	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacgatcttcgggaatattcGtcctggactctgtccaggcc	10	12	2	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr1:149885276G>A	uc001etg.2	-	2	608	c.117C>T	c.(115-117)GAC>GAT	p.D39D	SV2A_uc001eth.2_Silent_p.D39D	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	39	Cytoplasmic (Potential).|Interaction with SYT1 (By similarity).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	GGGAATATTCGTCCTGGACTC	0.542													A	149885276	A	A	149885276	2	1	222	1	0	0	0	0	0	0	0	1	15414	1136	40	1		1	SV2A	1	149885276	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	30443611	149885276	99365345	8	15515											
FLG	2312	broad.mit.edu	37	chr1	152283084	152283084	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccctgactggccacgtgcGgactctttgtggctctgctg	12	14	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr1:152283084G>A	uc001ezu.1	-	3	4314	c.4278C>T	c.(4276-4278)TCC>TCT	p.S1426S	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1426	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCACGTGCGGACTCTTTGT	0.557									Ichthyosis				A	152283084	A	A	152283084	2	1	222	1	0	0	0	0	0	0	0	1	5922	1103	39	2		2	FLG	1	152283084	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	2397808	152283084	96967537	9	15516											
E2F6	1876	broad.mit.edu	37	chr2	11587770	11587770	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccttcctcagggccttctGgatgagtgctctcagatgaa	10	11	3	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:11587770G>A	uc002rbh.2	-	6	1074	c.782C>T	c.(781-783)CCA>CTA	p.P261L	E2F6_uc002rbe.2_Missense_Mutation_p.P186L|E2F6_uc002rbf.2_Missense_Mutation_p.P229L|E2F6_uc002rbg.2_Missense_Mutation_p.P186L|E2F6_uc002rbi.2_Missense_Mutation_p.P186L|E2F6_uc010yjl.1_RNA	NM_198256	NP_937987	O75461	E2F6_HUMAN	E2F transcription factor 6	261	Transcription repression.				negative regulation of transcription from RNA polymerase II promoter	MLL1 complex|transcription factor complex	DNA binding|transcription corepressor activity			skin(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.114)|OV - Ovarian serous cystadenocarcinoma(76;0.168)		AGGGCCTTCTGGATGAGTGCT	0.398													A	11587770	A	A	11587770	3	1	222	1	0	0	0	0	1	0	0	0	4871	1348	47	3	71	3	E2F6	2	11587770	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08		11587770	231611603	10	15517											
MAP4K3	8491	broad.mit.edu	37	chr2	39509673	39509673	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgcactttaggtgttggaGgaagaccattactaataggc	11	7	0	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:39509673G>A	uc002rro.2	-	22	1701	c.1610C>T	c.(1609-1611)CCT>CTT	p.P537L	MAP4K3_uc002rrp.2_Missense_Mutation_p.P516L|MAP4K3_uc010yns.1_Missense_Mutation_p.P90L	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	537					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				AGGTGTTGGAGGAAGACCATT	0.323													A	39509673	A	A	39509673	3	1	222	1	0	0	0	0	1	0	0	0	9261	1000	35	3	1126	3	MAP4K3	2	39509673	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	27921903	39509673	203689700	11	15518											
PPM1B	5495	broad.mit.edu	37	chr2	44428594	44428594	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcactactaacgaagactttAgggcagctggaaaatcagga	10	8	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:44428594A>G	uc002rtt.2	+	2	684	c.256A>G	c.(256-258)AGG>GGG	p.R86G	PPM1B_uc002rts.2_Missense_Mutation_p.R86G|PPM1B_uc002rtu.2_Missense_Mutation_p.R86G|PPM1B_uc002rtv.2_Intron|PPM1B_uc002rtw.2_Missense_Mutation_p.R86G|PPM1B_uc002rtx.2_Missense_Mutation_p.R86G	NM_002706	NP_002697	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 1	86					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CGAAGACTTTAGGGCAGCTGG	0.383													G	44428594	G	G	44428594	3	3	222	1	0	0	0	0	1	0	0	0	12336	411	15	4	258	4	PPM1B	2	44428594	Missense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	4918921	44428594	198770779	12	15519											
POU3F3	5455	broad.mit.edu	37	chr2	105473303	105473303	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctggccgacagcctgcagctCgagaaggaggtggtgcgggt	18	10	0	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:105473303C>G	uc010ywg.1	+	1	1335	c.1335C>G	c.(1333-1335)CTC>CTG	p.L445L		NM_006236	NP_006227	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	445	Homeobox.				metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			ovary(1)	1						GCCTGCAGCTCGAGAAGGAGG	0.642													G	105473303	G	G	105473303	2	3	222	1	0	0	0	0	0	0	0	1	12276	871	31	5		5	POU3F3	2	105473303	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08	61044709	105473303	137726070	13	15520											
MERTK	10461	broad.mit.edu	37	chr2	112786347	112786347	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttaggaatggggtctcctGgtcccattcgagcatgctgc	13	10	1	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:112786347G>A	uc002thk.1	+	19	3028	c.2906G>A	c.(2905-2907)TGG>TAG	p.W969*	MERTK_uc002thl.1_Nonsense_Mutation_p.W793*	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	969	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GGGGTCTCCTGGTCCCATTCG	0.527													A	112786347	A	A	112786347	4	1	222	1	0	0	0	0	0	1	0	0	9479	1357	47	3	2980	3	MERTK	2	112786347	Nonsense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	7313044	112786347	130413026	14	15521											
MCM6	4175	broad.mit.edu	37	chr2	136627932	136627932	+	Splice_Site	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gacacaggtaagggtaaactCtgaaaaacaaaaaagtcagc	9	7	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:136627932C>G	uc002tuw.2	-	3	331	c.255_splice	c.e3-1	p.R85_splice		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6						cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	AGGGTAAACTCTGAAAAACAA	0.428													G	136627932	G	G	136627932	5	3	222	1	0	0	0	0	0	0	1	0	9391	927	32	5	2271	5	MCM6	2	136627932	Splice_Site	SNP	C	TCGA-32-1977-01A-01D-1353-08	23841585	136627932	106571441	15	15522											
ACVR1C	130399	broad.mit.edu	37	chr2	158412763	158412763	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcccatactgtcagcatcGcagctatggacaggaggcaa	11	11	1	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:158412763G>A	uc002tzk.3	-	3	629	c.386C>T	c.(385-387)GCG>GTG	p.A129V	ACVR1C_uc002tzl.3_Intron|ACVR1C_uc010fof.2_Intron|ACVR1C_uc010foe.2_Missense_Mutation_p.A79V	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	129	Helical; (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						TGTCAGCATCGCAGCTATGGA	0.478													A	158412763	A	A	158412763	3	1	222	1	0	0	0	0	1	0	0	0	222	1087	38	1	1123	1	ACVR1C	2	158412763	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	21784831	158412763	84786610	16	15523											
FAP	2191	broad.mit.edu	37	chr2	163070563	163070563	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gttcatcagtaacccacgtgAgccaactgaaataataatca	6	10	3	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:163070563A>T	uc002ucd.2	-	11	1095	c.887T>A	c.(886-888)CTC>CAC	p.L296H	FAP_uc010zct.1_Missense_Mutation_p.L271H|FAP_uc010fpd.2_Intron|FAP_uc010fpe.1_Missense_Mutation_p.L263H	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	296	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						AACCCACGTGAGCCAACTGAA	0.368													T	163070563	T	T	163070563	3	4	222	1	0	0	0	0	1	0	0	0	5673	304	11	5	1459	5	FAP	2	163070563	Missense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	4657800	163070563	80128810	17	15524											
LRP2	4036	broad.mit.edu	37	chr2	170115593	170115593	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaatactgaactactgtgcGtctcgttttatcagctagcc	7	10	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:170115593G>A	uc002ues.2	-	17	2668	c.2455C>T	c.(2455-2457)CGC>TGC	p.R819C	LRP2_uc010zdf.1_Missense_Mutation_p.R682C	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	819	LDL-receptor class B 7.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACTACTGTGCGTCTCGTTTTA	0.398													A	170115593	A	A	170115593	3	1	222	1	0	0	0	0	1	0	0	0	8956	1145	40	1	11764	1	LRP2	2	170115593	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	7045030	170115593	73083780	18	15525											
COL3A1	1281	broad.mit.edu	37	chr2	189867049	189867049	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gagaggtgaaactggccctcCaggacctgctggtttccctg	13	12	0	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:189867049C>G	uc002uqj.1	+	35	2534	c.2417C>G	c.(2416-2418)CCA>CGA	p.P806R		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	806	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	ACTGGCCCTCCAGGACCTGCT	0.438													G	189867049	G	G	189867049	3	3	222	1	0	0	0	0	1	0	0	0	3688	594	21	5	2555	5	COL3A1	2	189867049	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	19751456	189867049	53332324	19	15526											
MARCH4	57574	broad.mit.edu	37	chr2	217234856	217234856	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaggtcattgaagagcatgCggcagcggcacttgaggaga	15	8	2	4			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:217234856C>T	uc002vgb.2	-	1	1895	c.128G>A	c.(127-129)CGC>CAC	p.R43H		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	43						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GAAGAGCATGCGGCAGCGGCA	0.652													T	217234856	T	T	217234856	3	4	222	1	0	0	0	0	1	0	0	0	9303	768	27	1	1120	1	MARCH4	2	217234856	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	27367807	217234856	25964517	20	15527											
DIS3L2	129563	broad.mit.edu	37	chr2	233194556	233194556	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttcatgctcttggccaacatGgcagtggcccacaagatcca	9	13	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr2:233194556G>C	uc010fxz.2	+	15	2049	c.1773G>C	c.(1771-1773)ATG>ATC	p.M591I	DIS3L2_uc002vsm.3_Intron|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	591							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		TGGCCAACATGGCAGTGGCCC	0.657													C	233194556	C	C	233194556	3	2	222	1	0	0	0	0	1	0	0	0	4537	1348	47	5	1827	5	DIS3L2	2	233194556	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	15959700	233194556	10004817	21	15528											
ITIH4	3700	broad.mit.edu	37	chr3	52857940	52857940	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcatagctgacgtcgaaacCgaagcccaggcagaagaggc	14	11	0	3	rs141154056	byFrequency	TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr3:52857940C>T	uc003dfz.2	-	10	1288	c.1252G>A	c.(1252-1254)GGT>AGT	p.G418S	ITIH4_uc011bel.1_Missense_Mutation_p.G148S|ITIH4_uc003dfy.2_Missense_Mutation_p.G282S|ITIH4_uc011bem.1_Missense_Mutation_p.G418S|ITIH4_uc011ben.1_Missense_Mutation_p.G418S	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	418	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		ACGTCGAAACCGAAGCCCAGG	0.612													T	52857940	T	T	52857940	3	4	222	1	0	0	0	0	1	0	0	0	7906	652	23	2	1600	2	ITIH4	3	52857940	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08		52857940	145164490	22	15529											
IL17RB	55540	broad.mit.edu	37	chr3	53891662	53891662	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccacaccagaagaaacaaaCgcgagcttcagtggtgattc	10	11	1	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr3:53891662C>T	uc003dha.2	+	8	731	c.692C>T	c.(691-693)ACG>ATG	p.T231M		NM_018725	NP_061195	Q9NRM6	I17RB_HUMAN	interleukin 17B receptor precursor	231	Extracellular (Potential).				defense response|regulation of cell growth	extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)		AAGAAACAAACGCGAGCTTCA	0.373													T	53891662	T	T	53891662	3	4	222	1	0	0	0	0	1	0	0	0	7640	536	19	1	722	1	IL17RB	3	53891662	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	1033722	53891662	144130768	23	15530											
PTPRG	5793	broad.mit.edu	37	chr3	61975388	61975388	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acattttagaccagtatgcgCgtgttggggaagaataccag	12	7	0	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr3:61975388C>T	uc003dlb.2	+	3	999	c.280C>T	c.(280-282)CGT>TGT	p.R94C	PTPRG_uc003dlc.2_Missense_Mutation_p.R94C	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	94	Extracellular (Potential).|Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CCAGTATGCGCGTGTTGGGGA	0.488													T	61975388	T	T	61975388	3	4	222	1	0	0	0	0	1	0	0	0	12802	768	27	1	290	1	PTPRG	3	61975388	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	8083726	61975388	136047042	24	15531											
C3orf30	152405	broad.mit.edu	37	chr3	118865302	118865302	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacacctggtcaggctggccGcagagcatccaaccctgctg	11	15	1	1	rs138666071		TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr3:118865302G>A	uc003ecb.1	+	1	306	c.266G>A	c.(265-267)CGC>CAC	p.R89H	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.R89H	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	89										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		CAGGCTGGCCGCAGAGCATCC	0.502													A	118865302	A	A	118865302	3	1	222	1	0	0	0	0	1	0	0	0	2220	1087	38	1	268	1	C3orf30	3	118865302	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	56889914	118865302	79157128	25	15532											
OTOL1	131149	broad.mit.edu	37	chr3	161221595	161221595	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gcctctctcctcgtcatcttGaaattaagtgcaggagacca	8	12	3	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr3:161221595G>C	uc011bpb.1	+	4	1299	c.1299G>C	c.(1297-1299)TTG>TTC	p.L433F		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	433	C1q.					collagen					0						TCGTCATCTTGAAATTAAGTG	0.468													C	161221595	C	C	161221595	3	2	222	1	0	0	0	0	1	0	0	0	11304	1281	45	5	1313	5	OTOL1	3	161221595	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	42356293	161221595	36800835	26	15533											
TP63	8626	broad.mit.edu	37	chr3	189604307	189604307	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agcagcgcaacgccctcactCctacaaccattcctgatggc	7	17	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr3:189604307C>T	uc003fry.2	+	11	1563	c.1474C>T	c.(1474-1476)CCT>TCT	p.P492S	TP63_uc003frz.2_Missense_Mutation_p.P492S|TP63_uc010hzc.1_Missense_Mutation_p.P492S|TP63_uc003fsc.2_Missense_Mutation_p.P398S|TP63_uc003fsd.2_Missense_Mutation_p.P398S|TP63_uc010hzd.1_Missense_Mutation_p.P313S	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	492					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CGCCCTCACTCCTACAACCAT	0.498									Hay-Wells_syndrome	HNSCC(45;0.13)			T	189604307	T	T	189604307	3	4	222	1	0	0	0	0	1	0	0	0	16389	855	30	3	1681	3	TP63	3	189604307	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	28382712	189604307	8418123	27	15534											
FGFRL1	53834	broad.mit.edu	37	chr4	1019042	1019042	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cctaagttgtaccccaaactCtacacagacatccacacaca	3	16	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr4:1019042C>T	uc003gce.2	+	7	1583	c.1422C>T	c.(1420-1422)CTC>CTT	p.L474L	FGFRL1_uc003gcf.2_Silent_p.L474L|FGFRL1_uc003gcg.2_Silent_p.L474L|FGFRL1_uc010ibo.2_Silent_p.L474L	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	474	Cytoplasmic (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ACCCCAAACTCTacacagaca	0.473													T	1019042	T	T	1019042	2	4	222	1	0	0	0	0	0	0	0	1	5869	900	32	3		3	FGFRL1	4	1019042	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08		1019042	190135234	28	15535											
PCDH7	5099	broad.mit.edu	37	chr4	30725505	30725505	+	Frame_Shift_Del	DEL	G	-	-													tgcacaggttggtggtgcaaGtgaatgacagtgggcagcct							TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr4:30725505delG	uc003gsk.1	+	1	3469	c.2461delG	c.(2461-2463)GTGfs	p.V821fs	PCDH7_uc011bxw.1_Frame_Shift_Del_p.V774fs|PCDH7_uc011bxx.1_Frame_Shift_Del_p.V821fs	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	821	Extracellular (Potential).|Cadherin 7.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GGTGGTGCAAGTGAATGACAG	0.483													-	30725505	-	-	30725505	7	5	222	1	0	1	0	1	0	0	0	0	11516	1029	36	0	2463	0	PCDH7	4	30725505	Frame_Shift_Del	DEL	G	TCGA-32-1977-01A-01D-1353-08	29706463	30725505	160428771	29	15536											
CNGA1	1259	broad.mit.edu	37	chr4	47945299	47945299	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttattttcgtttttatcatcTgacttgctgaaaaaattaag	5	5	2	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr4:47945299T>A	uc003gxt.3	-	8	614	c.348A>T	c.(346-348)TCA>TCT	p.S116S	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Silent_p.S185S|CNGA1_uc003gxv.1_Silent_p.S116S	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	116	Cytoplasmic (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity	p.S116*(1)		ovary(2)	2						TTTTATCATCTGACTTGCTGA	0.189													A	47945299	A	A	47945299	2	1	222	1	0	0	0	0	0	0	0	1	3596	1567	55	5		5	CNGA1	4	47945299	Silent	SNP	T	TCGA-32-1977-01A-01D-1353-08	17219794	47945299	143208977	30	15537											
UGT2B28	54490	broad.mit.edu	37	chr4	70160416	70160416	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cagtaccactctttggatgtGattgggtttctgctggcctg	12	9	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr4:70160416G>T	uc003hej.2	+	6	1481	c.1479G>T	c.(1477-1479)GTG>GTT	p.V493V	UGT2B28_uc010ihr.2_3'UTR	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	493					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	CTTTGGATGTGATTGGGTTTC	0.463													T	70160416	T	T	70160416	2	4	222	1	0	0	0	0	0	0	0	1	16957	1277	45	5		5	UGT2B28	4	70160416	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	22215117	70160416	120993860	31	15538											
NAAA	27163	broad.mit.edu	37	chr4	76836138	76836138	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgtagtataaattgtgaaGctgaaaattatgaggaaatt	9	3	0	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr4:76836138G>A	uc003hjb.2	-	10	1063	c.999C>T	c.(997-999)AAC>AAT	p.N333N	NAAA_uc003hja.2_Intron	NM_014435	NP_055250	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase isoform 1	333					lipid metabolic process	lysosome	hydrolase activity			skin(1)	1						AAATTGTGAAGCTGAAAATTA	0.408													A	76836138	A	A	76836138	2	1	222	1	0	0	0	0	0	0	0	1	10127	985	34	3		3	NAAA	4	76836138	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	6675722	76836138	114318138	32	15539											
SHROOM3	57619	broad.mit.edu	37	chr4	77661454	77661454	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	accctgggaggaaagccgctCctgacctcgggagccatctg	13	14	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr4:77661454C>A	uc011cbx.1	+	5	3081	c.2128C>A	c.(2128-2130)CCT>ACT	p.P710T	SHROOM3_uc011cbz.1_Missense_Mutation_p.P534T|SHROOM3_uc003hkf.1_Missense_Mutation_p.P585T|SHROOM3_uc003hkg.2_Missense_Mutation_p.P488T	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	710					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GAAAGCCGCTCCTGACCTCGG	0.667													A	77661454	A	A	77661454	3	1	222	1	0	0	0	0	1	0	0	0	14295	855	30	5	2146	5	SHROOM3	4	77661454	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	825316	77661454	113492822	33	15540											
SEC24B	10427	broad.mit.edu	37	chr4	110437770	110437770	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggatatttgacaattttgtgCcagtcactcctagaaaatct	7	8	2	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr4:110437770C>A	uc003hzk.2	+	11	2155	c.2100C>A	c.(2098-2100)TGC>TGA	p.C700*	SEC24B_uc003hzl.2_Nonsense_Mutation_p.C665*|SEC24B_uc011cfp.1_Nonsense_Mutation_p.C730*|SEC24B_uc011cfq.1_Nonsense_Mutation_p.C699*|SEC24B_uc011cfr.1_Nonsense_Mutation_p.C664*	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	700					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CAATTTTGTGCCAGTCACTCC	0.318													A	110437770	A	A	110437770	4	1	222	1	0	0	0	0	0	1	0	0	13995	747	26	5	2142	5	SEC24B	4	110437770	Nonsense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	32776316	110437770	80716506	34	15541											
LYSMD3	116068	broad.mit.edu	37	chr5	89821101	89821101	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctacgattctgatgcctcccTgccataatgttaaaatctgg	7	11	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr5:89821101T>C	uc003kjr.2	-	2	154	c.6A>G	c.(4-6)GCA>GCG	p.A2A	LYSMD3_uc010jaz.1_Silent_p.A2A|LYSMD3_uc003kjs.1_Silent_p.A2A	NM_198273	NP_938014	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain	2	Extracellular (Potential).				cell wall macromolecule catabolic process	integral to membrane					0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		GATGCCTCCCTGCCATAATGT	0.403													C	89821101	C	C	89821101	2	2	222	1	0	0	0	0	0	0	0	1	9126	1567	55	4		4	LYSMD3	5	89821101	Silent	SNP	T	TCGA-32-1977-01A-01D-1353-08		89821101	91094159	35	15542											
C5orf36	285600	broad.mit.edu	37	chr5	93859726	93859726	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagttagccattcaaagcagTcagttgttgtttgcagctgc	10	8	2	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr5:93859726T>G	uc011cuk.1	-	4	466	c.209A>C	c.(208-210)GAC>GCC	p.D70A	C5orf36_uc003kkp.2_Missense_Mutation_p.D70A	NM_001145678	NP_001139150	Q8IV33	K0825_HUMAN	hypothetical protein LOC285600 isoform 1	70											0		all_cancers(142;2.12e-08)|all_epithelial(76;5.95e-11)|all_lung(232;0.000996)|Lung NSC(167;0.0108)|Ovarian(174;0.0218)|Colorectal(57;0.0329)|Breast(839;0.214)|Lung SC(612;0.236)		all cancers(79;3.96e-19)		TTCAAAGCAGTCAGTTGTTGT	0.318													G	93859726	G	G	93859726	3	3	222	1	0	0	0	0	1	0	0	0	2295	1667	58	5	3695	5	C5orf36	5	93859726	Missense_Mutation	SNP	T	TCGA-32-1977-01A-01D-1353-08	4038625	93859726	87055534	36	15543											
SLC27A6	28965	broad.mit.edu	37	chr5	128359401	128359401	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttggtgtattcatgtgaaaaAaggtaagacttctatttgaa	9	3	2	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr5:128359401A>G	uc003kuy.2	+	7	1649	c.1253A>G	c.(1252-1254)AAA>AGA	p.K418R	SLC27A6_uc003kuz.2_Missense_Mutation_p.K418R	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	418					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CATGTGAAAAAAGGTAAGACT	0.274													G	128359401	G	G	128359401	3	3	222	1	0	0	0	0	1	0	0	0	14530	14	1	4	1275	4	SLC27A6	5	128359401	Missense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	34499675	128359401	52555859	37	15544											
DOCK2	1794	broad.mit.edu	37	chr5	169097547	169097547	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgttttgtttccaacaggGcatttttcctaagtcattta	6	7	1	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr5:169097547G>A	uc003maf.2	+	4	250	c.170G>A	c.(169-171)GGC>GAC	p.G57D	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	57	SH3.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ttCCAACAGGGCATTTTTCCT	0.328													A	169097547	A	A	169097547	3	1	222	1	0	0	0	0	1	0	0	0	4687	1217	42	3	184	3	DOCK2	5	169097547	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	40738146	169097547	11817713	38	15545											
C6orf114	85411	broad.mit.edu	37	chr6	13470477	13470477	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggaaagaagggcaattgcCggctcatgaagcacatccct	11	11	1	2	rs150464914		TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr6:13470477C>T	uc003nav.2	-	2	559	c.36G>A	c.(34-36)CCG>CCA	p.P12P	GFOD1_uc003nas.1_Intron|GFOD1_uc003nat.1_Intron|C6orf114_uc003nau.2_RNA	NM_033069	NP_149060			hypothetical protein LOC85411												0	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0504)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.147)			GGGCAATTGCCGGCTCATGAA	0.572													T	13470477	T	T	13470477	2	4	222	1	0	0	0	0	0	0	0	1	2321	639	23	2		2	C6orf114	6	13470477	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08		13470477	157644590	39	15546											
PHF1	5252	broad.mit.edu	37	chr6	33382871	33382871	+	Frame_Shift_Del	DEL	C	-	-													cctcagcagtgcgcaatcagCccgagccccaggagcagagg							TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr6:33382871delC	uc003oeh.2	+	12	1425	c.1189delC	c.(1189-1191)CCCfs	p.P397fs	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Frame_Shift_Del_p.A393fs|PHF1_uc010jux.2_Frame_Shift_Del_p.P197fs	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	397					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				GCGCAATCAGCCCGAGCCCCA	0.677											OREG0017346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	33382871	-	-	33382871	7	5	222	1	0	1	0	1	0	0	0	0	11820	739	26	0	1231	0	PHF1	6	33382871	Frame_Shift_Del	DEL	C	TCGA-32-1977-01A-01D-1353-08	19912394	33382871	137732196	40	15547											
ZNF76	7629	broad.mit.edu	37	chr6	35261624	35261624	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaccatccccagtcctgatGccgacctggccacatctggc	8	18	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr6:35261624G>A	uc003oki.1	+	12	1631	c.1426G>A	c.(1426-1428)GCC>ACC	p.A476T	ZNF76_uc003okj.1_Intron	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	476					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGTCCTGATGCCGACCTGGC	0.627													A	35261624	A	A	35261624	3	1	222	1	0	0	0	0	1	0	0	0	18132	1319	46	3	1468	3	ZNF76	6	35261624	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	1878753	35261624	135853443	41	15548											
DNAH8	1769	broad.mit.edu	37	chr6	38998047	38998047	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccccaagctgtatgtgtgtcCtatttacaagaaacccaggc	8	12	0	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr6:38998047C>G	uc003ooe.1	+	91	13952	c.13352C>G	c.(13351-13353)CCT>CGT	p.P4451R		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TATGTGTGTCCTATTTACAAG	0.507													G	38998047	G	G	38998047	3	3	222	1	0	0	0	0	1	0	0	0	4607	681	24	5	13706	5	DNAH8	6	38998047	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	3736423	38998047	132117020	42	15549											
COL10A1	1300	broad.mit.edu	37	chr6	116442546	116442546	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggacctggtgggccaattgGtcccatttctcccggaaaac	12	12	1	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr6:116442546G>T	uc003pwm.2	-	3	829	c.733C>A	c.(733-735)CCA>ACA	p.P245T	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	245	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		GGGCCAATTGGTCCCATTTCT	0.597													T	116442546	T	T	116442546	3	4	222	1	0	0	0	0	1	0	0	0	3666	1261	44	5	1313	5	COL10A1	6	116442546	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	77444499	116442546	54672521	43	15550											
CRHR2	1395	broad.mit.edu	37	chr7	30695576	30695576	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcggatgtggtggacgcgCgtaactttgtcattaggatc	13	8	2	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr7:30695576C>T	uc003tbn.2	-	9	1128	c.884G>A	c.(883-885)CGC>CAC	p.R295H	CRHR2_uc010kvw.1_Missense_Mutation_p.R295H|CRHR2_uc010kvx.1_Missense_Mutation_p.R294H|CRHR2_uc010kvy.1_Missense_Mutation_p.R131H|CRHR2_uc003tbo.2_Missense_Mutation_p.R281H|CRHR2_uc003tbp.2_Missense_Mutation_p.R322H	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	295	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						GGTGGACGCGCGTAACTTTGT	0.552													T	30695576	T	T	30695576	3	4	222	1	0	0	0	0	1	0	0	0	3872	768	27	1	367	1	CRHR2	7	30695576	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08		30695576	128443087	44	15551											
GTF2IRD1	9569	broad.mit.edu	37	chr7	74004217	74004217	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agactcggggagaaggtgatCctgcgggagcaggtgaagga	19	6	0	4			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr7:74004217C>T	uc003uaq.2	+	23	2796	c.2403C>T	c.(2401-2403)ATC>ATT	p.I801I	GTF2IRD1_uc010lbq.2_Silent_p.I818I|GTF2IRD1_uc003uap.2_Silent_p.I786I|GTF2IRD1_uc003uar.1_Silent_p.I786I	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	801	GTF2I-like 5.					nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						AGAAGGTGATCCTGCGGGAGC	0.592													T	74004217	T	T	74004217	2	4	222	1	0	0	0	0	0	0	0	1	6868	845	30	3		3	GTF2IRD1	7	74004217	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08	43308641	74004217	85134446	45	15552											
CTTNBP2	83992	broad.mit.edu	37	chr7	117400762	117400762	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccttaagggtattttaagagCatctgttagaagagtaaaag	10	4	1	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr7:117400762C>A	uc003vjf.2	-	10	2991	c.2899G>T	c.(2899-2901)GCT>TCT	p.A967S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	967										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		ATTTTAAGAGCATCTGTTAGA	0.284													A	117400762	A	A	117400762	3	1	222	1	0	0	0	0	1	0	0	0	4045	710	25	5	2148	5	CTTNBP2	7	117400762	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	43396545	117400762	41737901	46	15553											
FLNC	2318	broad.mit.edu	37	chr7	128489530	128489530	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gatgtggttgagaaccatgaCggtacctttgacatctacta	10	8	1	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr7:128489530C>G	uc003vnz.3	+	30	5306	c.5097C>G	c.(5095-5097)GAC>GAG	p.D1699E	FLNC_uc003voa.3_Missense_Mutation_p.D1699E	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1699	Filamin 15.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AGAACCATGACGGTACCTTTG	0.612													G	128489530	G	G	128489530	3	3	222	1	0	0	0	0	1	0	0	0	5935	535	19	5	5215	5	FLNC	7	128489530	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	11088768	128489530	30649133	47	15554											
MEST	4232	broad.mit.edu	37	chr7	130140656	130140656	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cccagtctttgggccgtataCtcggccctctgagagtgagc	12	13	2	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr7:130140656C>G	uc003vqg.2	+	9	891	c.674C>G	c.(673-675)ACT>AGT	p.T225S	MEST_uc003vqc.2_Missense_Mutation_p.T216S|MEST_uc003vqd.2_Intron|MEST_uc003vqf.2_Missense_Mutation_p.T216S|MEST_uc011kph.1_Missense_Mutation_p.T211S|MEST_uc010lmg.2_Missense_Mutation_p.T225S	NM_002402	NP_002393	Q5EB52	MEST_HUMAN	mesoderm specific transcript isoform a	225					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)					GGGCCGTATACTCGGCCCTCT	0.428													G	130140656	G	G	130140656	3	3	222	1	0	0	0	0	1	0	0	0	9484	565	20	5	708	5	MEST	7	130140656	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	1651126	130140656	28998007	48	15555											
BPGM	669	broad.mit.edu	37	chr7	134346605	134346605	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagaacaagtgaggctctggAgaagaagctacaatgtaacc	11	7	1	4			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr7:134346605A>T	uc003vrv.2	+	3	887	c.346A>T	c.(346-348)AGA>TGA	p.R116*	BPGM_uc003vrw.2_Nonsense_Mutation_p.R116*|BPGM_uc003vrx.2_Nonsense_Mutation_p.R116*	NM_199186	NP_954655	P07738	PMGE_HUMAN	bisphosphoglycerate mutase	116					glycolysis|respiratory gaseous exchange		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						GAGGCTCTGGAGAAGAAGCTA	0.493													T	134346605	T	T	134346605	4	4	222	1	0	0	0	0	0	1	0	0	1488	296	11	5	348	5	BPGM	7	134346605	Nonsense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	4205949	134346605	24792058	49	15556											
CNTNAP2	26047	broad.mit.edu	37	chr7	147336290	147336290	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatactcagtgacacagctcGtttacagcgcctccatggac	8	13	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr7:147336290G>A	uc003weu.1	+	13	2506	c.1990G>A	c.(1990-1992)GTT>ATT	p.V664I		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	664	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GACACAGCTCGTTTACAGCGC	0.498										HNSCC(39;0.1)			A	147336290	A	A	147336290	3	1	222	1	0	0	0	0	1	0	0	0	3647	1145	40	1	2040	1	CNTNAP2	7	147336290	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	12989685	147336290	11802373	50	15557											
DPYSL2	1808	broad.mit.edu	37	chr8	26510765	26510765	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctggctgagctgagaggGgttcctcgtggcctgtatga	16	9	0	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr8:26510765G>A	uc003xfb.1	+	13	1829	c.1479G>A	c.(1477-1479)GGG>GGA	p.G493G	DPYSL2_uc003xfa.2_Silent_p.G598G|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Silent_p.G457G	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	493					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		AGCTGAGAGGGGTTCCTCGTG	0.602													A	26510765	A	A	26510765	2	1	222	1	0	0	0	0	0	0	0	1	4747	1219	43	3		3	DPYSL2	8	26510765	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08		26510765	119853257	51	15558											
FBXL6	26233	broad.mit.edu	37	chr8	145579316	145579316	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caggttgaggtagagcaggcCcgggcagctgctgatcacag	16	10	1	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr8:145579316C>G	uc003zcb.2	-	9	1520	c.1495G>C	c.(1495-1497)GGC>CGC	p.G499R	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_Missense_Mutation_p.G226R|FBXL6_uc003zca.2_Missense_Mutation_p.G493R|FBXL6_uc010mfx.2_Missense_Mutation_p.G260R|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	499	LRR 11.				proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			TAGAGCAGGCCCGGGCAGCTG	0.657													G	145579316	G	G	145579316	3	3	222	1	0	0	0	0	1	0	0	0	5723	623	22	5	128	5	FBXL6	8	145579316	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	119068551	145579316	784706	52	15559											
IFT74	80173	broad.mit.edu	37	chr9	26984346	26984346	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	attcagtatatttgtcatatGaaaagaggtgagtaataagt	9	2	2	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr9:26984346G>C	uc010mja.2	+	5	524	c.397G>C	c.(397-399)GAA>CAA	p.E133Q	IFT74_uc010mjb.2_Missense_Mutation_p.E133Q|IFT74_uc003zqf.3_Missense_Mutation_p.E133Q|IFT74_uc003zqg.3_Missense_Mutation_p.E133Q	NM_001099223	NP_001092693	Q96LB3	IFT74_HUMAN	coiled-coil domain containing 2 isoform a	133	Potential.					cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				skin(1)	1		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		TTTGTCATATGAAAAGAGGTG	0.264													C	26984346	C	C	26984346	3	2	222	1	0	0	0	0	1	0	0	0	7563	1291	45	5	411	5	IFT74	9	26984346	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08		26984346	114229085	53	15560											
GAPVD1	26130	broad.mit.edu	37	chr9	128069702	128069702	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gttttaacagagctgtgttgCcgctttccttgatgttgtga	11	7	0	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr9:128069702C>A	uc010mwx.2	+	7	1453	c.1127C>A	c.(1126-1128)GCC>GAC	p.A376D	GAPVD1_uc004bpo.2_Missense_Mutation_p.A376D|GAPVD1_uc011lzs.1_Missense_Mutation_p.A376D|GAPVD1_uc004bpp.2_Missense_Mutation_p.A376D|GAPVD1_uc004bpq.2_Missense_Mutation_p.A376D|GAPVD1_uc004bpr.2_Missense_Mutation_p.A376D|GAPVD1_uc004bps.2_Missense_Mutation_p.A376D|GAPVD1_uc010mwy.1_Missense_Mutation_p.A235D	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	376					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AGCTGTGTTGCCGCTTTCCTT	0.408													A	128069702	A	A	128069702	3	1	222	1	0	0	0	0	1	0	0	0	6239	739	26	5	1141	5	GAPVD1	9	128069702	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	101085356	128069702	13143729	54	15561											
SLC2A6	11182	broad.mit.edu	37	chr9	136338317	136338317	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacgccacgggcacgcagGggcaggacctcagacatgag	15	14	1	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr9:136338317G>A	uc004cee.2	-	9	1373	c.1278C>T	c.(1276-1278)CCC>CCT	p.P426P	SLC2A6_uc004cef.2_Silent_p.P364P|SLC2A6_uc004ceg.2_Silent_p.P403P	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	426	Cytoplasmic (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		GGGCACGCAGGGGCAGGACCT	0.672													A	136338317	A	A	136338317	2	1	222	1	0	0	0	0	0	0	0	1	14549	1219	43	3		3	SLC2A6	9	136338317	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	8268615	136338317	4875114	55	15562											
SLC18A3	6572	broad.mit.edu	37	chr10	50820049	50820049	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagtctatggcagcgtctaCgccatcgccgacatctccta	8	15	4	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr10:50820049C>T	uc001jhw.2	+	1	1703	c.1263C>T	c.(1261-1263)TAC>TAT	p.Y421Y	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	421	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GCAGCGTCTACGCCATCGCCG	0.622													T	50820049	T	T	50820049	2	4	222	1	0	0	0	0	0	0	0	1	14427	547	19	1		1	SLC18A3	10	50820049	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08		50820049	84714698	56	15563											
TMEM26	219623	broad.mit.edu	37	chr10	63212688	63212688	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttgaacttgagggtgagcGcagtctccaggaagagcaag	15	8	1	4			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr10:63212688G>A	uc001jlo.2	-	1	521	c.152C>T	c.(151-153)GCG>GTG	p.A51V	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlq.2_RNA|uc001jlr.2_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	51	Helical; (Potential).					integral to membrane					0	Prostate(12;0.0112)					GAGGGTGAGCGCAGTCTCCAG	0.642													A	63212688	A	A	63212688	3	1	222	1	0	0	0	0	1	0	0	0	16148	1087	38	1	978	1	TMEM26	10	63212688	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	12392639	63212688	72322059	57	15564											
ZNF365	22891	broad.mit.edu	37	chr10	64159484	64159484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagctcctggggtttggccGcaaaggcaacatcaggccca	14	12	1	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr10:64159484G>A	uc001jly.3	+	5	1267	c.1205G>A	c.(1204-1206)CGC>CAC	p.R402H	ZNF365_uc001jmb.3_Intron|ZNF365_uc001jmc.2_Intron|ZNF365_uc001jlz.3_Missense_Mutation_p.R387H|ZNF365_uc001jma.3_RNA	NM_014951	NP_055766	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform A	Error:Variant_position_missing_in_Q70YC4_after_alignment										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GGGTTTGGCCGCAAAGGCAAC	0.537													A	64159484	A	A	64159484	3	1	222	1	0	0	0	0	1	0	0	0	17866	1087	38	1	1174	1	ZNF365	10	64159484	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	946796	64159484	71375263	58	15565											
VCL	7414	broad.mit.edu	37	chr10	75849002	75849002	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagaaagctcagcaggtatcTcagggtctggatgtgctcac	12	10	4	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr10:75849002T>C	uc001jwd.2	+	9	1165	c.1071T>C	c.(1069-1071)TCT>TCC	p.S357S	VCL_uc009xrr.2_Silent_p.S106S|VCL_uc010qky.1_Silent_p.S264S|VCL_uc001jwe.2_Silent_p.S357S|VCL_uc010qkz.1_Intron	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	357	1.|N-terminal globular head.|3 X 112 AA tandem repeats.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					AGCAGGTATCTCAGGGTCTGG	0.488													C	75849002	C	C	75849002	2	2	222	1	0	0	0	0	0	0	0	1	17136	1538	54	4		4	VCL	10	75849002	Silent	SNP	T	TCGA-32-1977-01A-01D-1353-08	11689518	75849002	59685745	59	15566											
PTEN	5728	broad.mit.edu	37	chr10	89653808	89653808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccaaacattattgctatgGgatttcctgcagaaagactt	7	8	0	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr10:89653808G>A	uc001kfb.2	+	3	1137	c.106G>A	c.(106-108)GGA>AGA	p.G36R		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	36	Phosphatase tensin-type.		G -> R (in endometrial hyperplasia).|G -> E (in glioma).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(4)|p.G36E(4)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G36V(2)|p.G36*(1)|p.A34_G36del(1)|p.G36R(1)|p.G36fs*18(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TATTGCTATGGGATTTCCTGC	0.284		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89653808	A	A	89653808	3	1	222	1	0	0	0	0	1	0	0	0	12738	1233	43	3	112	3	PTEN	10	89653808	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	13804806	89653808	45880939	60	15567											
TNKS2	80351	broad.mit.edu	37	chr10	93619322	93619322	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tattttgctgaaaactcttcCaaaagcaatcaatatgtata	4	7	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr10:93619322C>A	uc001khp.2	+	25	3495	c.3198C>A	c.(3196-3198)TCC>TCA	p.S1066S		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1066	PARP catalytic.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding	p.S1066F(1)		kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				AAAACTCTTCCAAAAGCAATC	0.398													A	93619322	A	A	93619322	2	1	222	1	0	0	0	0	0	0	0	1	16318	581	21	5		5	TNKS2	10	93619322	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08	3965514	93619322	41915425	61	15568											
HPSE2	60495	broad.mit.edu	37	chr10	100374687	100374687	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggttaaaattctggtccaCgaggtgattgtatccatggt	12	6	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr10:100374687C>T	uc001kpn.1	-	9	1354	c.1294G>A	c.(1294-1296)GTG>ATG	p.V432M	HPSE2_uc009xwc.1_Missense_Mutation_p.V422M|HPSE2_uc001kpo.1_Missense_Mutation_p.V364M|HPSE2_uc009xwd.1_Missense_Mutation_p.V310M	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	432					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TTCTGGTCCACGAGGTGATTG	0.418													T	100374687	T	T	100374687	3	4	222	1	0	0	0	0	1	0	0	0	7345	536	19	1	538	1	HPSE2	10	100374687	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	6755365	100374687	35160060	62	15569											
DNMBP	23268	broad.mit.edu	37	chr10	101716779	101716779	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaaagccccattagggccCgggcttgtcccatggaatat	11	12	0	1	rs138795130		TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr10:101716779C>T	uc001kqj.2	-	4	544	c.452G>A	c.(451-453)CGG>CAG	p.R151Q	NCRNA00093_uc001kqk.1_RNA	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	151	SH3 3.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CATTAGGGCCCGGGCTTGTCC	0.557													T	101716779	T	T	101716779	3	4	222	1	0	0	0	0	1	0	0	0	4674	652	23	2	4337	2	DNMBP	10	101716779	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	1342092	101716779	33817968	63	15570											
OR51F2	119694	broad.mit.edu	37	chr11	4842972	4842972	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccagatgttctttctacaCggatttactttcatggagtc	8	10	3	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr11:4842972C>T	uc010qyn.1	+	1	357	c.357C>T	c.(355-357)CAC>CAT	p.H119H		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTTTCTACACGGATTTACTT	0.468													T	4842972	T	T	4842972	2	4	222	1	0	0	0	0	0	0	0	1	11097	535	19	1		1	OR51F2	11	4842972	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08		4842972	130163544	64	15571											
UEVLD	55293	broad.mit.edu	37	chr11	18587922	18587922	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atttttgcaatataggctagCaagtctacctgccgtgcctc	8	11	1	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr11:18587922C>G	uc001mot.2	-	5	545	c.465G>C	c.(463-465)TTG>TTC	p.L155F	UEVLD_uc001mou.2_Missense_Mutation_p.L155F|UEVLD_uc010rde.1_Missense_Mutation_p.L25F|UEVLD_uc010rdf.1_Missense_Mutation_p.L133F|UEVLD_uc010rdg.1_Missense_Mutation_p.L25F|UEVLD_uc001mov.2_Missense_Mutation_p.L133F|UEVLD_uc010rdh.1_Missense_Mutation_p.L155F	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	155					cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						TATAGGCTAGCAAGTCTACCT	0.368													G	18587922	G	G	18587922	3	3	222	1	0	0	0	0	1	0	0	0	16930	709	25	5	982	5	UEVLD	11	18587922	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	13744950	18587922	116418594	65	15572											
OR10AG1	282770	broad.mit.edu	37	chr11	55735344	55735344	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caatcaacagaaatggcaccGtgataaacaccaccgctact	6	13	1	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr11:55735344G>A	uc010rit.1	-	1	596	c.596C>T	c.(595-597)ACG>ATG	p.T199M		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					AAATGGCACCGTGATAAACAC	0.408													A	55735344	A	A	55735344	3	1	222	1	0	0	0	0	1	0	0	0	10897	1145	40	1	312	1	OR10AG1	11	55735344	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	37147422	55735344	79271172	66	15573											
OR10AG1	282770	broad.mit.edu	37	chr11	55735807	55735807	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atacatgggagtctggagagCggggtgaatttttattagta	14	3	1	2	rs139897319	byFrequency	TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr11:55735807C>T	uc010rit.1	-	1	133	c.133G>A	c.(133-135)GCT>ACT	p.A45T		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	45	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GTCTGGAGAGCGGGGTGAATT	0.348													T	55735807	T	T	55735807	3	4	222	1	0	0	0	0	1	0	0	0	10897	768	27	1	775	1	OR10AG1	11	55735807	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	463	55735807	79270709	67	15574											
SLC22A10	387775	broad.mit.edu	37	chr11	63071595	63071595	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagaaatgcagaccctgcGtgtggctttggcatgtctgg	14	10	1	2	rs112720090		TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr11:63071595G>A	uc009yor.2	+	8	1509	c.1301G>A	c.(1300-1302)CGT>CAT	p.R434H	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_Missense_Mutation_p.V228M	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	434	Cytoplasmic (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						CAGACCCTGCGTGTGGCTTTG	0.453													A	63071595	A	A	63071595	3	1	222	1	0	0	0	0	1	0	0	0	14441	1145	40	1	1331	1	SLC22A10	11	63071595	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	7335788	63071595	71934921	68	15575											
NAALADL1	10004	broad.mit.edu	37	chr11	64820765	64820765	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgctggggtccacagcccCgtgcacccagctgtctcggt	12	16	1	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr11:64820765C>T	uc001ocn.2	-	8	1139	c.1123G>A	c.(1123-1125)GGG>AGG	p.G375R	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	375	NAALADase.|Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						TCCACAGCCCCGTGCACCCAG	0.672													T	64820765	T	T	64820765	3	4	222	1	0	0	0	0	1	0	0	0	10129	652	23	2	1143	2	NAALADL1	11	64820765	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	1749170	64820765	70185751	69	15576											
PCNXL3	399909	broad.mit.edu	37	chr11	65402835	65402835	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacacgccctccctgctggcGctgcgccatgtcctggatga	11	16	0	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr11:65402835G>A	uc001oey.2	+	31	5100	c.5100G>A	c.(5098-5100)GCG>GCA	p.A1700A	PCNXL3_uc001oez.2_Silent_p.A587A	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1700						integral to membrane					0						CCCTGCTGGCGCTGCGCCATG	0.632													A	65402835	A	A	65402835	2	1	222	1	0	0	0	0	0	0	0	1	11593	1074	38	1		1	PCNXL3	11	65402835	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	582070	65402835	69603681	70	15577											
GDF3	9573	broad.mit.edu	37	chr12	7842931	7842931	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcaggctgaaaattcaccCctgagtctctatcttctttg	6	12	5	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr12:7842931C>T	uc001qte.2	-	2	674	c.638G>A	c.(637-639)GGG>GAG	p.G213E		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	213					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						AAAATTCACCCCTGAGTCTCT	0.493													T	7842931	T	T	7842931	3	4	222	1	0	0	0	0	1	0	0	0	6315	623	22	3	460	3	GDF3	12	7842931	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08		7842931	126008964	71	15578											
NELL2	4753	broad.mit.edu	37	chr12	45173691	45173691	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggctaaggagagcttgtgCcacttgtcatcagccaaaat	10	9	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr12:45173691C>T	uc001rog.2	-	4	1045	c.450G>A	c.(448-450)TGG>TGA	p.W150*	NELL2_uc001rof.3_Nonsense_Mutation_p.W149*|NELL2_uc001roh.2_Nonsense_Mutation_p.W150*|NELL2_uc009zkd.2_Nonsense_Mutation_p.W149*|NELL2_uc010skz.1_Nonsense_Mutation_p.W200*|NELL2_uc010sla.1_Nonsense_Mutation_p.W173*|NELL2_uc001roi.1_Nonsense_Mutation_p.W150*|NELL2_uc010slb.1_Nonsense_Mutation_p.W149*|NELL2_uc001roj.2_Nonsense_Mutation_p.W150*	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	150	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		AGAGCTTGTGCCACTTGTCAT	0.438													T	45173691	T	T	45173691	4	4	222	1	0	0	0	0	0	1	0	0	10334	740	26	3	2068	3	NELL2	12	45173691	Nonsense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	37330760	45173691	88678204	72	15579											
ARID2	196528	broad.mit.edu	37	chr12	46245949	46245949	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agaacaaatagacatgcaagAtatcaaaagtgatttgagaa	8	4	1	5			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr12:46245949A>T	uc001ros.1	+	15	4043	c.4043A>T	c.(4042-4044)GAT>GTT	p.D1348V	ARID2_uc001ror.2_Missense_Mutation_p.D1348V|ARID2_uc009zkg.1_Missense_Mutation_p.D804V|ARID2_uc009zkh.1_Missense_Mutation_p.D975V|ARID2_uc001rou.1_Missense_Mutation_p.D682V	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1348					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GACATGCAAGATATCAAAAGT	0.358													T	46245949	T	T	46245949	3	4	222	1	0	0	0	0	1	0	0	0	915	333	12	5	4101	5	ARID2	12	46245949	Missense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	1072258	46245949	87605946	73	15580											
KRT78	196374	broad.mit.edu	37	chr12	53242331	53242331	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggctgagttgaccctcacCttgtcaatgaaggaagcaaa	10	9	2	3			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr12:53242331C>T	uc001sbc.1	-	1	448	c.384G>A	c.(382-384)AAG>AAA	p.K128K		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	128	Coil 1A.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						TGACCCTCACCTTGTCAATGA	0.537													T	53242331	T	T	53242331	2	4	222	1	0	0	0	0	0	0	0	1	8491	695	24	3		3	KRT78	12	53242331	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08	6996382	53242331	80609564	74	15581											
SLC24A6	80024	broad.mit.edu	37	chr12	113770568	113770568	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcacacctgaagctggaaacTgggggctaatgtgagctcct	12	10	1	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr12:113770568T>A	uc001tvc.2	-	2	326	c.116A>T	c.(115-117)CAG>CTG	p.Q39L	SLC24A6_uc001tvd.1_Missense_Mutation_p.Q39L	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	39	Extracellular (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						AGCTGGAAACTGGGGGCTAAT	0.527													A	113770568	A	A	113770568	3	1	222	1	0	0	0	0	1	0	0	0	14470	1580	55	5	1698	5	SLC24A6	12	113770568	Missense_Mutation	SNP	T	TCGA-32-1977-01A-01D-1353-08	60528237	113770568	20081327	75	15582											
TBX5	6910	broad.mit.edu	37	chr12	114832695	114832695	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttgtgcatggaatttagaaTaatctaaaaataataaagaa	6	2	1	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr12:114832695T>A	uc001tvo.2	-	6	1009	c.514A>T	c.(514-516)ATT>TTT	p.I172F	TBX5_uc001tvp.2_Missense_Mutation_p.I172F|TBX5_uc001tvq.2_Missense_Mutation_p.I122F|TBX5_uc010syv.1_Missense_Mutation_p.I172F	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	172	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GAATTTAGAATAATCTAAAAA	0.368													A	114832695	A	A	114832695	3	1	222	1	0	0	0	0	1	0	0	0	15658	1406	49	5	1125	5	TBX5	12	114832695	Missense_Mutation	SNP	T	TCGA-32-1977-01A-01D-1353-08	1062127	114832695	19019200	76	15583											
TAOK3	51347	broad.mit.edu	37	chr12	118639103	118639103	+	Frame_Shift_Del	DEL	C	-	-													aaaataaattgaacctacttCctcatcctcctgtgactcat							TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr12:118639103delC	uc001twx.2	-	12	1280	c.985delG	c.(985-987)GAAfs	p.E329fs	TAOK3_uc001tww.2_Frame_Shift_Del_p.E159fs|TAOK3_uc001twy.3_Frame_Shift_Del_p.E329fs	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	329					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAACCTACTTCCTCATCCTCC	0.234													-	118639103	-	-	118639103	7	5	222	1	0	1	0	1	0	0	0	0	15546	864	30	0	1751	0	TAOK3	12	118639103	Frame_Shift_Del	DEL	C	TCGA-32-1977-01A-01D-1353-08	3806408	118639103	15212792	77	15584											
UCHL3	7347	broad.mit.edu	37	chr13	76134909	76134909	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tttcttaaacaattaggtctAcatcctaactggcaattcgt	5	9	2	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr13:76134909A>T	uc001vjq.2	+	3	105	c.75A>T	c.(73-75)CTA>CTT	p.L25L	UCHL3_uc001vjr.2_5'UTR	NM_006002	NP_005993	P15374	UCHL3_HUMAN	ubiquitin carboxyl-terminal esterase L3	25					ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity				0				GBM - Glioblastoma multiforme(99;0.0125)		AATTAGGTCTACATCCTAACT	0.333													T	76134909	T	T	76134909	2	4	222	1	0	0	0	0	0	0	0	1	16918	378	14	5		5	UCHL3	13	76134909	Silent	SNP	A	TCGA-32-1977-01A-01D-1353-08		76134909	39034969	78	15585											
POTEG	404785	broad.mit.edu	37	chr14	19553823	19553823	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagccgaggtaccacgtccGtcgagaagatctggacaagc	14	11	1	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr14:19553823G>A	uc001vuz.1	+	1	459	c.407G>A	c.(406-408)CGT>CAT	p.R136H	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	136								p.R136H(1)		ovary(1)	1						TACCACGTCCGTCGAGAAGAT	0.577													A	19553823	A	A	19553823	3	1	222	1	0	0	0	0	1	0	0	0	12266	1145	40	1	409	1	POTEG	14	19553823	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08		19553823	87795717	79	15586											
OXA1L	5018	broad.mit.edu	37	chr14	23239044	23239044	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttttcctctcatcgtgacgGgccagcgagaggcagccagg	13	12	1	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr14:23239044G>A	uc001wgn.2	+	4	664	c.664G>A	c.(664-666)GGC>AGC	p.G222S	OXA1L_uc001wgo.2_RNA|OXA1L_uc010akc.2_Missense_Mutation_p.G222S|OXA1L_uc001wgp.2_Missense_Mutation_p.G146S|OXA1L_uc001wgq.2_5'UTR	NM_005015	NP_005006	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	162	Mitochondrial intermembrane (Potential).				aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)	1	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		CATCGTGACGGGCCAGCGAGA	0.488													A	23239044	A	A	23239044	3	1	222	1	0	0	0	0	1	0	0	0	11328	1232	43	3	678	3	OXA1L	14	23239044	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	3685221	23239044	84110496	80	15587											
PCK2	5106	broad.mit.edu	37	chr14	24567814	24567814	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgacccgactggggacaccTgtgcttcaggccctgggaga	14	12	1	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr14:24567814T>C	uc001wlt.2	+	4	723	c.591T>C	c.(589-591)CCT>CCC	p.P197P	NRL_uc001wlq.2_Intron|PCK2_uc001wlr.1_Silent_p.P209P|PCK2_uc001wls.2_Silent_p.P197P|PCK2_uc010tnw.1_Silent_p.P63P|PCK2_uc010ald.2_Silent_p.P49P|PCK2_uc010ale.2_Silent_p.P63P|PCK2_uc010tnx.1_Silent_p.P63P|PCK2_uc001wlu.3_Silent_p.P63P	NM_004563	NP_004554	Q16822	PCKGM_HUMAN	mitochondrial phosphoenolpyruvate carboxykinase	197					gluconeogenesis	mitochondrial matrix	GTP binding|metal ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0184)		TGGGGACACCTGTGCTTCAGG	0.617													C	24567814	C	C	24567814	2	2	222	1	0	0	0	0	0	0	0	1	11582	1567	55	4		4	PCK2	14	24567814	Silent	SNP	T	TCGA-32-1977-01A-01D-1353-08	1328770	24567814	82781726	81	15588											
FOXG1	2290	broad.mit.edu	37	chr14	29237322	29237322	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcggcgccgctccaccacCtcgcgggccaagctggcctt	12	19	0	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr14:29237322C>T	uc001wqe.2	+	1	1036	c.837C>T	c.(835-837)ACC>ACT	p.T279T		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	279					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GCTCCACCACCTCGCGGGCCA	0.701													T	29237322	T	T	29237322	2	4	222	1	0	0	0	0	0	0	0	1	6007	668	24	3		3	FOXG1	14	29237322	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08	4669508	29237322	78112218	82	15589											
TDRD9	122402	broad.mit.edu	37	chr14	104488645	104488645	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaggtgcaaggcatgaacGtctcaaagctcaggaacaca	12	9	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr14:104488645G>A	uc001yom.3	+	24	2614	c.2584G>A	c.(2584-2586)GTC>ATC	p.V862I	TDRD9_uc001yon.3_Missense_Mutation_p.V600I	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	862					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				AGGCATGAACGTCTCAAAGCT	0.448													A	104488645	A	A	104488645	3	1	222	1	0	0	0	0	1	0	0	0	15733	1145	40	1	2678	1	TDRD9	14	104488645	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	75251323	104488645	2860895	83	15590											
PLD4	122618	broad.mit.edu	37	chr14	105397140	105397140	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccaagacctggagaagaCcttccagacctactgggtac	11	13	0	4			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr14:105397140C>T	uc001ypu.1	+	7	920	c.779C>T	c.(778-780)ACC>ATC	p.T260I	PLD4_uc010tyl.1_Missense_Mutation_p.T267I	NM_138790	NP_620145	Q96BZ4	PLD4_HUMAN	phospholipase D4	260					lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|skin(1)	2		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	CTGGAGAAGACCTTCCAGACC	0.572													T	105397140	T	T	105397140	3	4	222	1	0	0	0	0	1	0	0	0	12048	507	18	3	801	3	PLD4	14	105397140	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	908495	105397140	1952400	84	15591											
GPR132	29933	broad.mit.edu	37	chr14	105518239	105518239	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccaggcagagcaggtagaCggccagcacgttgccctgca	14	13	0	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr14:105518239C>T	uc001yqd.2	-	4	1134	c.235G>A	c.(235-237)GTC>ATC	p.V79I	GPR132_uc001yqc.2_5'UTR|GPR132_uc001yqe.2_Missense_Mutation_p.V70I	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	79	Cytoplasmic (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		AGCAGGTAGACGGCCAGCACG	0.657													T	105518239	T	T	105518239	3	4	222	1	0	0	0	0	1	0	0	0	6642	536	19	1	911	1	GPR132	14	105518239	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	121099	105518239	1831301	85	15592											
PLA2G4F	255189	broad.mit.edu	37	chr15	42442026	42442026	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagagaggtcaaagccaaggCgtaggtctaggtccccggag	15	10	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr15:42442026C>T	uc001zoz.2	-	11	1007	c.944G>A	c.(943-945)CGC>CAC	p.R315H	PLA2G4F_uc001zoy.2_5'Flank|PLA2G4F_uc010bcr.2_Missense_Mutation_p.R66H|PLA2G4F_uc001zpa.2_Missense_Mutation_p.R66H|PLA2G4F_uc010bcs.2_Missense_Mutation_p.R102H	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	315	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		AAAGCCAAGGCGTAGGTCTAG	0.632													T	42442026	T	T	42442026	3	4	222	1	0	0	0	0	1	0	0	0	12006	768	27	1	1645	1	PLA2G4F	15	42442026	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08		42442026	60089366	86	15593											
TLN2	83660	broad.mit.edu	37	chr15	63055766	63055766	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcactattccttccagggacAaggcccctggacagagggag	13	12	0	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr15:63055766A>C	uc002alb.3	+	37	4966	c.4966A>C	c.(4966-4968)AAG>CAG	p.K1656Q	TLN2_uc002alc.3_Missense_Mutation_p.K49Q|TLN2_uc002ald.2_Missense_Mutation_p.K49Q	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1656					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TTCCAGGGACAAGGCCCCTGG	0.617													C	63055766	C	C	63055766	3	2	222	1	0	0	0	0	1	0	0	0	15945	131	5	5	5112	5	TLN2	15	63055766	Missense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	20613740	63055766	39475626	87	15594											
C15orf39	56905	broad.mit.edu	37	chr15	75503308	75503308	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaccagtgccagcccacctGgccccacactgaaggcccgc	9	20	0	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr15:75503308G>A	uc002azp.3	+	3	3315	c.2995G>A	c.(2995-2997)GGC>AGC	p.G999S	C15orf39_uc002azq.3_Missense_Mutation_p.G999S|C15orf39_uc002azr.3_3'UTR	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	999											0						CAGCCCACCTGGCCCCACACT	0.662													A	75503308	A	A	75503308	3	1	222	1	0	0	0	0	1	0	0	0	1793	1348	47	3	3001	3	C15orf39	15	75503308	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	12447542	75503308	27028084	88	15595											
C15orf27	123591	broad.mit.edu	37	chr15	76496348	76496348	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccttctcccccgccgctgCcatcccagcagcaggtggag	11	19	1	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr15:76496348C>T	uc002bbq.2	+	11	1443	c.1288C>T	c.(1288-1290)CCA>TCA	p.P430S	C15orf27_uc010bkp.2_Missense_Mutation_p.P246S|C15orf27_uc002bbr.2_Missense_Mutation_p.P246S|C15orf27_uc002bbs.2_Missense_Mutation_p.P108S	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	430						integral to membrane					0						CCCGCCGCTGCCATCCCAGCA	0.701													T	76496348	T	T	76496348	3	4	222	1	0	0	0	0	1	0	0	0	1788	739	26	3	1326	3	C15orf27	15	76496348	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	993040	76496348	26035044	89	15596											
DECR2	26063	broad.mit.edu	37	chr16	460737	460737	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactgccaccctggggaaccGggggcaggcgctccaggtgc	16	15	0	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr16:460737G>A	uc002chb.2	+	6	615	c.509G>A	c.(508-510)CGG>CAG	p.R170Q	DECR2_uc002chc.2_Missense_Mutation_p.R86Q|DECR2_uc010bqv.2_Missense_Mutation_p.R86Q|DECR2_uc002chd.2_Missense_Mutation_p.R86Q|DECR2_uc002che.1_RNA	NM_020664	NP_065715	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2	170						peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding				0		Hepatocellular(16;0.00015)				CTGGGGAACCGGGGGCAGGCG	0.701													A	460737	A	A	460737	3	1	222	1	0	0	0	0	1	0	0	0	4383	1116	39	2	531	2	DECR2	16	460737	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08		460737	89894016	90	15597											
IGFALS	3483	broad.mit.edu	37	chr16	1841525	1841525	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggctggcgatggcgttgtgGgacagccgcagcacacgcag	17	11	0	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr16:1841525G>A	uc002cmy.2	-	2	975	c.894C>T	c.(892-894)TCC>TCT	p.S298S	IGFALS_uc010uvn.1_Silent_p.S336S|IGFALS_uc010uvo.1_5'UTR	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	298	LRR 10.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0						TGGCGTTGTGGGACAGCCGCA	0.687													A	1841525	A	A	1841525	2	1	222	1	0	0	0	0	0	0	0	1	7577	1219	43	3		3	IGFALS	16	1841525	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	1380788	1841525	88513228	91	15598											
PRSS22	64063	broad.mit.edu	37	chr16	2903295	2903295	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggccagcagccaggcgccGtccacctggcacatgagggg	15	16	0	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr16:2903295G>A	uc002cry.1	-	6	819	c.753C>T	c.(751-753)GAC>GAT	p.D251D	PRSS22_uc002crz.1_Silent_p.D141D	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	251	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						GCCAGGCGCCGTCCACCTGGC	0.711													A	2903295	A	A	2903295	2	1	222	1	0	0	0	0	0	0	0	1	12619	1136	40	1		1	PRSS22	16	2903295	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	1061770	2903295	87451458	92	15599											
DNAH3	55567	broad.mit.edu	37	chr16	21045351	21045351	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttataagcagaggtcttgccGcccatggggtctcctacaat	10	11	2	1	rs143127393	by1000genomes	TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr16:21045351G>A	uc010vbe.1	-	36	5142	c.5142C>T	c.(5140-5142)GGC>GGT	p.G1714G		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1714	ATP (Potential).|AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGGTCTTGCCGCCCATGGGGT	0.498													A	21045351	A	A	21045351	2	1	222	1	0	0	0	0	0	0	0	1	4603	1074	38	1		1	DNAH3	16	21045351	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	18142056	21045351	69309402	93	15600											
ITGAD	3681	broad.mit.edu	37	chr16	31427865	31427865	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggagctccctggagctcaaCgtgattgtgactgtgtggaa	15	8	1	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr16:31427865C>T	uc002ebv.1	+	20	2446	c.2397C>T	c.(2395-2397)AAC>AAT	p.N799N	ITGAD_uc010cap.1_Silent_p.N800N	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	799	Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TGGAGCTCAACGTGATTGTGA	0.617													T	31427865	T	T	31427865	2	4	222	1	0	0	0	0	0	0	0	1	7884	535	19	1		1	ITGAD	16	31427865	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08	10382514	31427865	58926888	94	15601											
ZFHX3	463	broad.mit.edu	37	chr16	72993903	72993903	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctcaggctgtccaagggccCgtggctctcgcctgtggact	13	15	2	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr16:72993903C>A	uc002fck.2	-	2	815	c.142G>T	c.(142-144)GGG>TGG	p.G48W	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	48					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TCCAAGGGCCCGTGGCTCTCG	0.667													A	72993903	A	A	72993903	3	1	222	1	0	0	0	0	1	0	0	0	17631	652	23	5	11005	5	ZFHX3	16	72993903	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	41566038	72993903	17360850	95	15602											
USP22	23326	broad.mit.edu	37	chr17	20924447	20924447	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgcattttccaagcttttcGctgctcctccttggcgatta	7	12	0	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr17:20924447G>T	uc002gym.3	-	3	601	c.397C>A	c.(397-399)CGA>AGA	p.R133R	USP22_uc002gyn.3_Silent_p.R121R|USP22_uc002gyl.3_Silent_p.R28R	NM_015276	NP_056091	Q9UPT9	UBP22_HUMAN	ubiquitin thiolesterase 22	133					cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1						CAAGCTTTTCGCTGCTCCTCC	0.478													T	20924447	T	T	20924447	2	4	222	1	0	0	0	0	0	0	0	1	17051	1095	38	5		5	USP22	17	20924447	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08		20924447	60270763	96	15603											
KIF2B	84643	broad.mit.edu	37	chr17	51901070	51901070	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaagcggcctctcaaccagCgagagacaaccttaaaggac	11	12	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr17:51901070C>T	uc002iua.2	+	1	832	c.676C>T	c.(676-678)CGA>TGA	p.R226*	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	226	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TCTCAACCAGCGAGAGACAAC	0.557													T	51901070	T	T	51901070	4	4	222	1	0	0	0	0	0	1	0	0	8298	760	27	1	678	1	KIF2B	17	51901070	Nonsense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	30976623	51901070	29294140	97	15604											
MARCH10	162333	broad.mit.edu	37	chr17	60879073	60879073	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acatcgctgaagaacttctgCctgtcccttgcgtcatgcaa	8	13	2	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr17:60879073C>A	uc010ddr.2	-	2	262	c.24G>T	c.(22-24)AGG>AGT	p.R8S	MARCH10_uc002jag.3_Missense_Mutation_p.R8S|MARCH10_uc010dds.2_Missense_Mutation_p.R8S|MARCH10_uc002jah.2_Missense_Mutation_p.R8S	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	8							ligase activity|zinc ion binding				0						AGAACTTCTGCCTGTCCCTTG	0.453													A	60879073	A	A	60879073	3	1	222	1	0	0	0	0	1	0	0	0	9299	738	26	5	2442	5	MARCH10	17	60879073	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	8978003	60879073	20316137	98	15605											
LRRC37A3	374819	broad.mit.edu	37	chr17	62856062	62856062	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgttagtgttttccataaaaAcattttcttcaaaggcattt	5	6	2	0	rs139735390	by1000genomes	TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr17:62856062A>C	uc002jey.2	-	11	4733	c.4202T>G	c.(4201-4203)GTT>GGT	p.V1401G	LRRC37A3_uc010wqg.1_Missense_Mutation_p.V519G|LRRC37A3_uc002jex.1_Missense_Mutation_p.V378G|LRRC37A3_uc010wqf.1_Missense_Mutation_p.V439G|LRRC37A3_uc010dek.1_Missense_Mutation_p.V407G	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1401	Extracellular (Potential).					integral to membrane					0						TTCCATAAAAACATTTTCTTC	0.368													C	62856062	C	C	62856062	3	2	222	1	0	0	0	0	1	0	0	0	8993	43	2	5	718	5	LRRC37A3	17	62856062	Missense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	1976989	62856062	18339148	99	15606											
HELZ	9931	broad.mit.edu	37	chr17	65119252	65119252	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgctctaataggattgccaAtaagtacagaaggattgggc	11	6	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr17:65119252A>G	uc010wqk.1	-	26	3654	c.3467T>C	c.(3466-3468)ATT>ACT	p.I1156T	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.I1155T	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGGATTGCCAATAAGTACAGA	0.388													G	65119252	G	G	65119252	3	3	222	1	0	0	0	0	1	0	0	0	7049	101	4	4	2396	4	HELZ	17	65119252	Missense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	2263190	65119252	16075958	100	15607											
KIF19	124602	broad.mit.edu	37	chr17	72345437	72345437	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agattgatgagcagactgggCggggccaggcccggggccgg	20	10	0	4			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr17:72345437C>T	uc002jkm.3	+	10	1300	c.1162C>T	c.(1162-1164)CGG>TGG	p.R388W	KIF19_uc002jkj.2_Missense_Mutation_p.R388W|KIF19_uc002jkk.2_Missense_Mutation_p.R346W|KIF19_uc002jkl.2_Missense_Mutation_p.R346W	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	388	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GCAGACTGGGCGGGGCCAGGC	0.662													T	72345437	T	T	72345437	3	4	222	1	0	0	0	0	1	0	0	0	8282	759	27	1	1200	1	KIF19	17	72345437	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	7226185	72345437	8849773	101	15608											
CBX2	84733	broad.mit.edu	37	chr17	77758656	77758656	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcagctcggactccgaccccGactccgcctcgccgcccagc	10	22	0	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr17:77758656G>A	uc002jxc.2	+	5	1456	c.1414G>A	c.(1414-1416)GAC>AAC	p.D472N		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	472					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CTCCGACCCCGACTCCGCCTC	0.662													A	77758656	A	A	77758656	3	1	222	1	0	0	0	0	1	0	0	0	2718	1058	37	2	1780	2	CBX2	17	77758656	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	5413219	77758656	3436554	102	15609											
FOXK2	3607	broad.mit.edu	37	chr17	80521333	80521333	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgagtctccagtgaaggccGtacagccacacatctcgccc	9	16	2	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr17:80521333G>A	uc002kfn.2	+	2	694	c.523G>A	c.(523-525)GTA>ATA	p.V175I	FOXK2_uc002kfm.1_Missense_Mutation_p.V175I|FOXK2_uc010diu.2_Missense_Mutation_p.V175I	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	175					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			AGTGAAGGCCGTACAGCCACA	0.582													A	80521333	A	A	80521333	3	1	222	1	0	0	0	0	1	0	0	0	6015	1145	40	1	529	1	FOXK2	17	80521333	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	2762677	80521333	673877	103	15610											
CCDC102B	79839	broad.mit.edu	37	chr18	66504203	66504204	+	In_Frame_Ins	INS	-	TAT	TAT													tataacaccaacaaatgggaINStatttgtgaagaacttcgcc							TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr18:66504203_66504204insTAT	uc002lkk.2	+	4	426_427	c.203_204insTAT	c.(202-204)GAT>GATATT	p.69_70insI	CCDC102B_uc002lki.2_In_Frame_Ins_p.69_70insI|CCDC102B_uc002lkj.1_In_Frame_Ins_p.69_70insI	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	69_70										ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AACAAATGGGATATTTGTGAAG	0.505													TAT	66504204	TAT	TAT	66504203	7	5	222	1	0	1	1	0	0	0	0	0	2737	333	12	0	205	0	CCDC102B	18	66504203	In_Frame_Ins	INS	-	TCGA-32-1977-01A-01D-1353-08		66504203	11573045	104	15611											
LRRC8E	80131	broad.mit.edu	37	chr19	7963647	7963647	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	cctcgggggatccctgagcaGattggggccctgcaggaggt	17	11	0	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr19:7963647G>T	uc002mir.2	+	3	341	c.240G>T	c.(238-240)CAG>CAT	p.Q80H		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	80						integral to membrane				lung(1)|pancreas(1)	2						TCCCTGAGCAGATTGGGGCCC	0.522													T	7963647	T	T	7963647	3	4	222	1	0	0	0	0	1	0	0	0	9025	933	33	5	246	5	LRRC8E	19	7963647	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08		7963647	51165336	105	15612											
TNPO2	30000	broad.mit.edu	37	chr19	12817567	12817567	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acaggcactggatcaggtgcGggatcagctcaggcaggtag	16	9	3	0			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr19:12817567G>T	uc002muo.2	-	13	1498	c.1313C>A	c.(1312-1314)CCG>CAG	p.P438Q	TNPO2_uc002mup.2_Missense_Mutation_p.P530Q|TNPO2_uc002muq.2_Missense_Mutation_p.P438Q|TNPO2_uc002mur.2_Missense_Mutation_p.P438Q|SNORD41_uc002mut.1_5'Flank	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	438	HEAT 7.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						GATCAGGTGCGGGATCAGCTC	0.632													T	12817567	T	T	12817567	3	4	222	1	0	0	0	0	1	0	0	0	16333	1116	39	5	1428	5	TNPO2	19	12817567	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	4853920	12817567	46311416	106	15613											
ZNF676	163223	broad.mit.edu	37	chr19	22363820	22363820	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggattgaggatcgattaaaAgctttgccacattcttcaca	8	8	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr19:22363820A>T	uc002nqs.1	-	3	1017	c.699T>A	c.(697-699)GCT>GCA	p.A233A		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	233	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ATCGATTAAAAGCTTTGCCAC	0.358													T	22363820	T	T	22363820	2	4	222	1	0	0	0	0	0	0	0	1	18080	59	3	5		5	ZNF676	19	22363820	Silent	SNP	A	TCGA-32-1977-01A-01D-1353-08	9546253	22363820	36765163	107	15614											
RYR1	6261	broad.mit.edu	37	chr19	38983254	38983254	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagaaacctgaggaggagcgGtcagcagaggagagcaaacc	16	8	1	4			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr19:38983254G>A	uc002oit.2	+	38	6382	c.6252G>A	c.(6250-6252)CGG>CGA	p.R2084R	RYR1_uc002oiu.2_Silent_p.R2084R	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2084	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGGAGGAGCGGTCAGCAGAGG	0.627													A	38983254	A	A	38983254	2	1	222	1	0	0	0	0	0	0	0	1	13768	1248	44	3		3	RYR1	19	38983254	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	16619434	38983254	20145729	108	15615											
TIMM50	92609	broad.mit.edu	37	chr19	39972604	39972604	+	Frame_Shift_Del	DEL	A	-	-													cagagggtcccagctatgccAaaaaagttgcgctctggctt							TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr19:39972604delA	uc002olu.1	+	2	632	c.499delA	c.(499-501)AAAfs	p.K167fs	TIMM50_uc002olt.1_RNA	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	64	Mitochondrial matrix (Potential).				mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGCTATGCCAAAAAAGTTGC	0.607													-	39972604	-	-	39972604	7	5	222	1	0	1	0	1	0	0	0	0	15910	131	5	0	505	0	TIMM50	19	39972604	Frame_Shift_Del	DEL	A	TCGA-32-1977-01A-01D-1353-08	989350	39972604	19156379	109	15616											
ZNF284	342909	broad.mit.edu	37	chr19	44589943	44589943	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtcttgccagcaaatctgGgaacaaactgcaagtgagtt	11	8	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr19:44589943G>A	uc002oyg.1	+	5	528	c.312G>A	c.(310-312)TGG>TGA	p.W104*	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AGCAAATCTGGGAACAAACTG	0.468													A	44589943	A	A	44589943	4	1	222	1	0	0	0	0	0	1	0	0	17818	1241	43	3	326	3	ZNF284	19	44589943	Nonsense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08	4617339	44589943	14539040	110	15617											
ZNF528	84436	broad.mit.edu	37	chr19	52918709	52918709	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttagagcatctgcaagccttActaaccaagtaatccataac	5	11	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr19:52918709A>C	uc002pzh.2	+	7	1030	c.604A>C	c.(604-606)ACT>CCT	p.T202P	ZNF528_uc002pzi.2_5'UTR	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		TGCAAGCCTTACTAACCAAGT	0.398													C	52918709	C	C	52918709	3	2	222	1	0	0	0	0	1	0	0	0	17966	391	14	5	618	5	ZNF528	19	52918709	Missense_Mutation	SNP	A	TCGA-32-1977-01A-01D-1353-08	8328766	52918709	6210274	111	15618											
NLRP12	91662	broad.mit.edu	37	chr19	54314485	54314485	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attcccctaggcgcgcattgCggtcttccatgagccggaat	11	13	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr19:54314485C>T	uc002qch.3	-	3	648	c.428G>A	c.(427-429)CGC>CAC	p.R143H	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.R143H|NLRP12_uc002qcj.3_Missense_Mutation_p.R143H|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.R143H	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	143					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GCGCGCATTGCGGTCTTCCAT	0.567													T	54314485	T	T	54314485	3	4	222	1	0	0	0	0	1	0	0	0	10474	768	27	1	2885	1	NLRP12	19	54314485	Missense_Mutation	SNP	C	TCGA-32-1977-01A-01D-1353-08	1395776	54314485	4814498	112	15619											
ZNF416	55659	broad.mit.edu	37	chr19	58084494	58084494	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagggtggactctttgcaGctgaacaagggagcactcac	12	11	2	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr19:58084494G>A	uc002qpf.2	-	4	949	c.778C>T	c.(778-780)CTG>TTG	p.L260L	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	260	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		ACTCTTTGCAGCTGAACAAGG	0.458													A	58084494	A	A	58084494	2	1	222	1	0	0	0	0	0	0	0	1	17890	962	34	3		3	ZNF416	19	58084494	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08	3770009	58084494	1044489	113	15620											
TRPM2	7226	broad.mit.edu	37	chr21	45786765	45786765	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagaacttcaacatgaagccGcggctgaagagcattttccg	10	10	1	4			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr21:45786765G>A	uc002zet.1	+	5	765	c.552G>A	c.(550-552)CCG>CCA	p.P184P	TRPM2_uc002zeu.1_Silent_p.P184P|TRPM2_uc002zew.1_Silent_p.P184P|TRPM2_uc010gpt.1_Silent_p.P184P|TRPM2_uc002zex.1_5'Flank	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	184	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACATGAAGCCGCGGCTGAAGA	0.637													A	45786765	A	A	45786765	2	1	222	1	0	0	0	0	0	0	0	1	16583	1074	38	1		1	TRPM2	21	45786765	Silent	SNP	G	TCGA-32-1977-01A-01D-1353-08		45786765	2343130	114	15621											
LZTR1	8216	broad.mit.edu	37	chr22	21343151	21343151	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatctttgctggctatgacGgcaacgccaggtgggtggtg	17	8	1	1			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chr22:21343151G>A	uc002zto.2	+	6	686	c.583G>A	c.(583-585)GGC>AGC	p.G195S	LZTR1_uc002ztn.2_Missense_Mutation_p.G154S|LZTR1_uc011ahy.1_Missense_Mutation_p.G176S|LZTR1_uc010gsr.1_Missense_Mutation_p.G66S	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	195	Kelch 3.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGGCTATGACGGCAACGCCAG	0.637													A	21343151	A	A	21343151	3	1	222	1	0	0	0	0	1	0	0	0	9137	1116	39	2	605	2	LZTR1	22	21343151	Missense_Mutation	SNP	G	TCGA-32-1977-01A-01D-1353-08		21343151	29961415	115	15622											
SYTL5	94122	broad.mit.edu	37	chrX	37955451	37955451	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactcagaggatactgtaagCataagaagcaagtctgtccc	10	9	2	2			TCGA-32-1977-01A-01D-1353-08	TCGA-32-1977-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	18b48e97-cf39-48e8-8d60-d19de637ff5d	36421180-ef2e-4177-9a7a-ae779a45fc6a	g.chrX:37955451C>T	uc004ddu.2	+	10	1560	c.1026C>T	c.(1024-1026)AGC>AGT	p.S342S	SYTL5_uc004ddv.2_Silent_p.S342S|SYTL5_uc004ddx.2_Silent_p.S342S	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	342					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						ATACTGTAAGCATAAGAAGCA	0.413													T	37955451	T	T	37955451	2	4	222	1	0	0	0	0	0	0	0	1	15483	709	25	3		3	SYTL5	23	37955451	Silent	SNP	C	TCGA-32-1977-01A-01D-1353-08		37955451	117315109	116	15623											
GRHL3	57822	broad.mit.edu	37	chr1	24669384	24669384	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcttccttctcccatcaggcGtcaagggctgcctgctgtcg	11	15	3	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr1:24669384G>A	uc001biy.2	+	11	1349	c.1303G>A	c.(1303-1305)GTC>ATC	p.V435I	GRHL3_uc001bix.2_Missense_Mutation_p.V430I|GRHL3_uc001biz.2_Missense_Mutation_p.V337I	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	430					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CCCATCAGGCGTCAAGGGCTG	0.632													A	24669384	A	A	24669384	3	1	223	1	0	0	0	0	1	0	0	0	6765	1145	40	1	1366	1	GRHL3	1	24669384	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08		24669384	224581237	1	15624											
YTHDF2	51441	broad.mit.edu	37	chr1	29069013	29069013	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgaagctgcttggtctacGgggggtgacacagccatgcc	16	10	1	2	rs11553689		TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr1:29069013G>A	uc001brc.2	+	4	728	c.231G>A	c.(229-231)ACG>ACA	p.T77T	YTHDF2_uc001brd.2_Silent_p.T74T|YTHDF2_uc010ofx.1_Silent_p.T27T|YTHDF2_uc001bre.2_Silent_p.T27T	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	77					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CTTGGTCTACGGGGGGTGACA	0.502													A	29069013	A	A	29069013	2	1	223	1	0	0	0	0	0	0	0	1	17496	1103	39	2		2	YTHDF2	1	29069013	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	4399629	29069013	220181608	2	15625											
BRDT	676	broad.mit.edu	37	chr1	92445139	92445139	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attacaggatgttttcgaaaCgcatttttcaaagatcccga	7	8	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr1:92445139C>T	uc001dok.3	+	8	1461	c.1112C>T	c.(1111-1113)ACG>ATG	p.T371M	BRDT_uc001dol.3_Missense_Mutation_p.T371M|BRDT_uc010osz.1_Missense_Mutation_p.T375M|BRDT_uc009wdf.2_Missense_Mutation_p.T298M|BRDT_uc010ota.1_Missense_Mutation_p.T325M|BRDT_uc010otb.1_Missense_Mutation_p.T325M|BRDT_uc001dom.3_Missense_Mutation_p.T371M	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GTTTTCGAAACGCATTTTTCA	0.318													T	92445139	T	T	92445139	3	4	223	1	0	0	0	0	1	0	0	0	1508	536	19	1	1138	1	BRDT	1	92445139	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	63376126	92445139	156805482	3	15626											
APH1A	51107	broad.mit.edu	37	chr1	150241179	150241179	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggccgggccgaacgcgacgAaagtgcagccgaaaaacacc	13	13	0	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr1:150241179A>G	uc001ety.1	-	1	354	c.32T>C	c.(31-33)TTC>TCC	p.F11S	APH1A_uc010pbx.1_Missense_Mutation_p.F11S|APH1A_uc001etz.1_Missense_Mutation_p.F11S|APH1A_uc001eua.1_Missense_Mutation_p.F11S|APH1A_uc010pby.1_Missense_Mutation_p.F11S|APH1A_uc001eub.1_5'UTR|APH1A_uc010pbz.1_5'UTR	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	11	Helical; Name=1; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAACGCGACGAAAGTGCAGCC	0.662													G	150241179	G	G	150241179	3	3	223	1	0	0	0	0	1	0	0	0	771	246	9	4	804	4	APH1A	1	150241179	Missense_Mutation	SNP	A	TCGA-32-1979-01A-01D-1696-08	57796040	150241179	99009442	4	15627											
OR6N2	81442	broad.mit.edu	37	chr1	158746549	158746549	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttaatgatttccttgttacGaagactgtagataattggat	8	4	0	3	rs144962739		TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr1:158746549G>A	uc010pir.1	-	1	877	c.877C>T	c.(877-879)CGT>TGT	p.R293C		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TCCTTGTTACGAAGACTGTAG	0.418													A	158746549	A	A	158746549	3	1	223	1	0	0	0	0	1	0	0	0	11207	1058	37	2	79	2	OR6N2	1	158746549	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	8505370	158746549	90504072	5	15628											
GPR25	2848	broad.mit.edu	37	chr1	200842843	200842843	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctgctactgccgcatctcGcgccgcctgcgacggccgcc	11	19	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr1:200842843G>A	uc001gvn.1	+	1	678	c.678G>A	c.(676-678)TCG>TCA	p.S226S		NM_005298	NP_005289	O00155	GPR25_HUMAN	G protein-coupled receptor 25	226	Cytoplasmic (Potential).					integral to plasma membrane				ovary(1)	1						GCCGCATCTCGCGCCGCCTGC	0.682													A	200842843	A	A	200842843	2	1	223	1	0	0	0	0	0	0	0	1	6683	1074	38	1		1	GPR25	1	200842843	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	42096294	200842843	48407778	6	15629											
DUSP10	11221	broad.mit.edu	37	chr1	221879666	221879666	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atgggggtgagctcagcgttCtcgatgtcaggggtggtggg	20	6	3	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr1:221879666C>G	uc001hmy.1	-	3	1136	c.954G>C	c.(952-954)GAG>GAC	p.E318D	DUSP10_uc001hmx.1_5'UTR|DUSP10_uc001hmz.1_5'UTR	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	318					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GCTCAGCGTTCTCGATGTCAG	0.632													G	221879666	G	G	221879666	3	3	223	1	0	0	0	0	1	0	0	0	4810	912	32	5	502	5	DUSP10	1	221879666	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	21036823	221879666	27370955	7	15630											
APOB	338	broad.mit.edu	37	chr2	21233457	21233457	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcttcaggtttctctgtaCgttttccagtacaactataa	7	9	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr2:21233457C>T	uc002red.2	-	26	6411	c.6283G>A	c.(6283-6285)GTA>ATA	p.V2095I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2095	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTCTCTGTACGTTTTCCAGT	0.368													T	21233457	T	T	21233457	3	4	223	1	0	0	0	0	1	0	0	0	785	536	19	1	7424	1	APOB	2	21233457	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08		21233457	221965916	8	15631											
TMEM150A	129303	broad.mit.edu	37	chr2	85828199	85828199	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cttgggacccccttgctcagCagggtcaggagggcaggact	15	12	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr2:85828199C>G	uc002spw.1	-	3	866	c.145G>C	c.(145-147)GCT>CCT	p.A49P	USP39_uc002sqb.2_5'Flank|TMEM150A_uc002spx.1_5'UTR|TMEM150A_uc002spz.1_Silent_p.L18L|TMEM150A_uc002sqa.1_5'UTR|TMEM150A_uc002spy.1_Missense_Mutation_p.A49P	NM_001031738	NP_001026908	Q86TG1	T150A_HUMAN	transmembrane protein 150A isoform 1	49	Extracellular (Potential).					integral to membrane|plasma membrane					0						CCTTGCTCAGCAGGGTCAGGA	0.642													G	85828199	G	G	85828199	3	3	223	1	0	0	0	0	1	0	0	0	16064	710	25	5	690	5	TMEM150A	2	85828199	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	64594742	85828199	157371174	9	15632											
BAZ2B	29994	broad.mit.edu	37	chr2	160241783	160241783	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gactttcagtaagctcagttTgtccacagtgggcttccata	9	10	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr2:160241783T>C	uc002uao.2	-	23	3921	c.3569A>G	c.(3568-3570)CAA>CGA	p.Q1190R	BAZ2B_uc002uap.2_Missense_Mutation_p.Q1154R	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AAGCTCAGTTTGTCCACAGTG	0.438													C	160241783	C	C	160241783	3	2	223	1	0	0	0	0	1	0	0	0	1332	1812	63	4	2997	4	BAZ2B	2	160241783	Missense_Mutation	SNP	T	TCGA-32-1979-01A-01D-1696-08	74413584	160241783	82957590	10	15633											
ARPC2	10109	broad.mit.edu	37	chr2	219103491	219103492	+	Frame_Shift_Del	DEL	TT	-	-													gaaattgttttgcctctgtcTttgaaaaatacttccaattc							TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr2:219103491_219103492delTT	uc002vhd.2	+	6	485_486	c.373_374delTT	c.(373-375)TTTfs	p.F125fs	ARPC2_uc002vhe.2_Frame_Shift_Del_p.F125fs|ARPC2_uc002vhf.2_Frame_Shift_Del_p.F11fs	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	125					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		TGCCTCTGTCTTTGAAAAATAC	0.416													-	219103492	-	-	219103491	7	5	223	1	0	1	0	1	0	0	0	0	971	1609	56	0	391	0	ARPC2	2	219103491	Frame_Shift_Del	DEL	TT	TCGA-32-1979-01A-01D-1696-08	58861708	219103491	24095882	11	15634											
UGT1A5	54579	broad.mit.edu	37	chr2	234621782	234621782	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagcatgcgggaggccttgCgggacctccatgcgagaggc	16	12	1	1	rs41270755	byFrequency	TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr2:234621782C>T	uc002vuw.2	+	1	145	c.145C>T	c.(145-147)CGG>TGG	p.R49W	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Missense_Mutation_p.R49W	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	49					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GGAGGCCTTGCGGGACCTCCA	0.582													T	234621782	T	T	234621782	3	4	223	1	0	0	0	0	1	0	0	0	16945	759	27	1	147	1	UGT1A5	2	234621782	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	15518291	234621782	8577591	12	15635											
WDR82	80335	broad.mit.edu	37	chr3	52304745	52304745	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	taccgtctattttgttagagCtgtaaacaactgtgtttgct	8	7	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr3:52304745C>G	uc003ddl.2	-	2	524	c.242G>C	c.(241-243)AGC>ACC	p.S81T	WDR82_uc003ddk.2_5'Flank|uc011bee.1_5'Flank|MIRLET7G_hsa-let-7g|MI0000433_5'Flank	NM_025222	NP_079498	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	81					histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding				0				BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		TTTGTTAGAGCTGTAAACAAC	0.378													G	52304745	G	G	52304745	3	3	223	1	0	0	0	0	1	0	0	0	17328	797	28	5	731	5	WDR82	3	52304745	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08		52304745	145717685	13	15636											
DNAH12	201625	broad.mit.edu	37	chr3	57493505	57493505	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcattatcttctcttctgcGtttctagtttgtattgatag	6	7	5	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr3:57493505G>A	uc003dit.2	-	8	943	c.762C>T	c.(760-762)AAC>AAT	p.N254N	DNAH12_uc003diu.2_Silent_p.N254N	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	dynein heavy chain domain 2 isoform 1	254	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2						TCTCTTCTGCGTTTCTAGTTT	0.333													A	57493505	A	A	57493505	2	1	223	1	0	0	0	0	0	0	0	1	4600	1136	40	1		1	DNAH12	3	57493505	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	5188760	57493505	140528925	14	15637											
AADACL2	344752	broad.mit.edu	37	chr3	151475339	151475339	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttatttacgtctaggtcttaGgataagagatatgtatgtaa	9	3	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr3:151475339G>A	uc003ezc.2	+	5	1283	c.1163G>A	c.(1162-1164)AGG>AAG	p.R388K	AADACL2_uc010hvn.2_Missense_Mutation_p.R175K	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	388						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CTAGGTCTTAGGATAAGAGAT	0.328													A	151475339	A	A	151475339	3	1	223	1	0	0	0	0	1	0	0	0	11	1000	35	3	1181	3	AADACL2	3	151475339	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	93981834	151475339	46547091	15	15638											
PIK3CA	5290	broad.mit.edu	37	chr3	178952152	178952152	+	Nonstop_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaacagcatgcattgaactgAaaagataactgagaaaatga	8	5	0	5			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr3:178952152A>G	uc003fjk.2	+	21	3364	c.3207A>G	c.(3205-3207)TGA>TGG	p.*1069W		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1069					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.*1069_*1069insWKDN*(3)|p.*1069fs*3(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CATTGAACTGAAAAGATAACT	0.393		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			G	178952152	G	G	178952152	4	3	223	1	0	0	0	0	0	0	0	0	11913	259	9	4	3285	4	PIK3CA	3	178952152	Nonstop_Mutation	SNP	A	TCGA-32-1979-01A-01D-1696-08	27476813	178952152	19070278	16	15639											
GABRG1	2565	broad.mit.edu	37	chr4	46043099	46043099	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagagtcaattttggcaatgCgtatgtgtatccttccttcc	8	9	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr4:46043099C>T	uc003gxb.2	-	9	1456	c.1304G>A	c.(1303-1305)CGC>CAC	p.R435H		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	435	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTTGGCAATGCGTATGTGTAT	0.403													T	46043099	T	T	46043099	3	4	223	1	0	0	0	0	1	0	0	0	6171	768	27	1	97	1	GABRG1	4	46043099	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08		46043099	145111177	17	15640											
FRYL	285527	broad.mit.edu	37	chr4	48536560	48536560	+	Splice_Site	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtaagttttgtggtcactcAcctgtacatatttgccaata	7	8	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr4:48536560A>C	uc003gyh.1	-	49	7310	c.6705_splice	c.e49+1	p.Q2235_splice	FRYL_uc003gyg.1_Splice_Site_p.Q931_splice|FRYL_uc003gyi.1_Splice_Site_p.Q1123_splice|FRYL_uc003gyj.1_Splice_Site_p.Q530_splice	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						gtggtcacTCACCTGTACATA	0.194													C	48536560	C	C	48536560	5	2	223	1	0	0	0	0	0	0	1	0	6064	173	6	5	2398	5	FRYL	4	48536560	Splice_Site	SNP	A	TCGA-32-1979-01A-01D-1696-08	2493461	48536560	142617716	18	15641											
UGT2B28	54490	broad.mit.edu	37	chr4	70160487	70160487	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttttgtctgttttgtttctGgaagtttgctagaaaaggga	12	3	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr4:70160487G>A	uc003hej.2	+	6	1552	c.1550G>A	c.(1549-1551)TGG>TAG	p.W517*	UGT2B28_uc010ihr.2_3'UTR	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	517	Helical; (Potential).				xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	TTTTGTTTCTGGAAGTTTGCT	0.413													A	70160487	A	A	70160487	4	1	223	1	0	0	0	0	0	1	0	0	16957	1357	47	3	1572	3	UGT2B28	4	70160487	Nonsense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	21623927	70160487	120993789	19	15642											
ANKRD17	26057	broad.mit.edu	37	chr4	73959897	73959897	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgatattacagcctcctctTccaatcactctggatatcac	4	13	4	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr4:73959897T>C	uc003hgp.2	-	28	5343	c.5226A>G	c.(5224-5226)GGA>GGG	p.G1742G	ANKRD17_uc003hgo.2_Silent_p.G1629G|ANKRD17_uc003hgq.2_Silent_p.G1491G|ANKRD17_uc003hgr.2_Silent_p.G1741G	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1742	KH.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGCCTCCTCTTCCAATCACTC	0.333													C	73959897	C	C	73959897	2	2	223	1	0	0	0	0	0	0	0	1	646	1770	62	4		4	ANKRD17	4	73959897	Silent	SNP	T	TCGA-32-1979-01A-01D-1696-08	3799410	73959897	117194379	20	15643											
TRAM1L1	133022	broad.mit.edu	37	chr4	118005491	118005491	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagtctactctatttgaagtTtccactcccactccgttttc	4	14	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr4:118005491T>G	uc003ibv.3	-	1	1246	c.1059A>C	c.(1057-1059)GAA>GAC	p.E353D		NM_152402	NP_689615	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like	353	Cytoplasmic (Potential).				protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)	1						TATTTGAAGTTTCCACTCCCA	0.393													G	118005491	G	G	118005491	3	3	223	1	0	0	0	0	1	0	0	0	16449	1838	64	5	54	5	TRAM1L1	4	118005491	Missense_Mutation	SNP	T	TCGA-32-1979-01A-01D-1696-08	44045594	118005491	73148785	21	15644											
TKTL2	84076	broad.mit.edu	37	chr4	164394680	164394680	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggagaggatgaaccggtcGttgtccgggtgttctgggtc	17	8	1	2	rs114941835	by1000genomes	TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr4:164394680G>A	uc003iqp.3	-	1	368	c.207C>T	c.(205-207)AAC>AAT	p.N69N		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	69						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGAACCGGTCGTTGTCCGGGT	0.557													A	164394680	A	A	164394680	2	1	223	1	0	0	0	0	0	0	0	1	15933	1136	40	1		1	TKTL2	4	164394680	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	46389189	164394680	26759596	22	15645											
IRX2	153572	broad.mit.edu	37	chr5	2749815	2749815	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttgcggtacgcggggtcgttGagctggtacgggtaggccgc	19	9	0	1	rs138413279	byFrequency	TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr5:2749815G>A	uc003jda.2	-	2	578	c.336C>T	c.(334-336)CTC>CTT	p.L112L	C5orf38_uc003jdc.2_5'Flank|C5orf38_uc011cmg.1_5'Flank|C5orf38_uc011cmh.1_5'Flank|C5orf38_uc011cmi.1_5'Flank|C5orf38_uc011cmj.1_5'Flank|IRX2_uc003jdb.2_Silent_p.L112L	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	112	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		CGGGGTCGTTGAGCTGGTACG	0.682													A	2749815	A	A	2749815	2	1	223	1	0	0	0	0	0	0	0	1	7844	1277	45	3		3	IRX2	5	2749815	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08		2749815	178165445	23	15646											
UGT3A2	167127	broad.mit.edu	37	chr5	36036029	36036029	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgctgtgtggggctgagcGggtgggagcgcaggatgaca	21	8	0	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr5:36036029G>A	uc003jjz.1	-	7	1436	c.1343C>T	c.(1342-1344)CCG>CTG	p.P448L	UGT3A2_uc011cos.1_Missense_Mutation_p.P414L|UGT3A2_uc011cot.1_Missense_Mutation_p.P146L	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	448	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGGGCTGAGCGGGTGGGAGCG	0.597													A	36036029	A	A	36036029	3	1	223	1	0	0	0	0	1	0	0	0	16961	1116	39	2	232	2	UGT3A2	5	36036029	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	33286214	36036029	144879231	24	15647											
HCN1	348980	broad.mit.edu	37	chr5	45303809	45303809	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttacccacggctccttctcGtatgatataatctccaggtt	6	12	2	1	rs35229491		TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr5:45303809G>A	uc003jok.2	-	6	1535	c.1510C>T	c.(1510-1512)CGA>TGA	p.R504*		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	504	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GCTCCTTCTCGTATGATATAA	0.403													A	45303809	A	A	45303809	4	1	223	1	0	0	0	0	0	1	0	0	6996	1153	40	1	1174	1	HCN1	5	45303809	Nonsense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	9267780	45303809	135611451	25	15648											
P4HA2	8974	broad.mit.edu	37	chr5	131544873	131544873	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaggctctcgtaaacatcCctctcaggcaggtagtccac	9	14	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr5:131544873C>T	uc003kwh.2	-	7	1425	c.861G>A	c.(859-861)AGG>AGA	p.R287R	P4HA2_uc003kwg.2_Silent_p.R287R|P4HA2_uc003kwi.2_Silent_p.R287R|P4HA2_uc003kwk.2_Silent_p.R287R|P4HA2_uc003kwl.2_Silent_p.R287R|P4HA2_uc003kwj.2_Silent_p.R287R	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	287						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	CGTAAACATCCCTCTCAGGCA	0.542													T	131544873	T	T	131544873	2	4	223	1	0	0	0	0	0	0	0	1	11357	622	22	3		3	P4HA2	5	131544873	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08	86241064	131544873	49370387	26	15649											
PCDH12	51294	broad.mit.edu	37	chr5	141336339	141336339	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agcttctgacaccagtgatgGctgggaggcccatgtgacgt	14	10	1	3			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr5:141336339G>C	uc003llx.2	-	1	2289	c.1078C>G	c.(1078-1080)CCA>GCA	p.P360A		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	360	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCAGTGATGGCTGGGAGGCC	0.507													C	141336339	C	C	141336339	3	2	223	1	0	0	0	0	1	0	0	0	11510	1203	42	5	2492	5	PCDH12	5	141336339	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	9791466	141336339	39578921	27	15650											
PDE6A	5145	broad.mit.edu	37	chr5	149265912	149265912	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggccaaggcctctaggtccGtgaagtagcgcttcagcttt	12	11	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr5:149265912G>A	uc003lrg.3	-	14	1874	c.1754C>T	c.(1753-1755)ACG>ATG	p.T585M		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	585					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CTCTAGGTCCGTGAAGTAGCG	0.532													A	149265912	A	A	149265912	3	1	223	1	0	0	0	0	1	0	0	0	11645	1145	40	1	864	1	PDE6A	5	149265912	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	7929573	149265912	31649348	28	15651											
FAM71B	153745	broad.mit.edu	37	chr5	156590194	156590194	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggagagactggcggcccccGccatcgaggtggaagtacct	16	12	0	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr5:156590194G>A	uc003lwn.2	-	2	1182	c.1082C>T	c.(1081-1083)GCG>GTG	p.A361V		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	361						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGCGGCCCCCGCCATCGAGGT	0.567													A	156590194	A	A	156590194	3	1	223	1	0	0	0	0	1	0	0	0	5608	1087	38	1	739	1	FAM71B	5	156590194	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	7324282	156590194	24325066	29	15652											
GABRB2	2561	broad.mit.edu	37	chr5	160721114	160721114	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacataataaagccaatagaCgatgttgaagaaggaaaaaa	8	5	0	3			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr5:160721114C>T	uc003lys.1	-	11	1731	c.1513G>A	c.(1513-1515)GTC>ATC	p.V505I	GABRB2_uc011deh.1_Missense_Mutation_p.V306I|GABRB2_uc003lyr.1_Missense_Mutation_p.V467I|GABRB2_uc003lyt.1_Missense_Mutation_p.V467I|GABRB2_uc010jiu.1_Missense_Mutation_p.V404I	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	505	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGCCAATAGACGATGTTGAAG	0.453													T	160721114	T	T	160721114	3	4	223	1	0	0	0	0	1	0	0	0	6167	536	19	1	29	1	GABRB2	5	160721114	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	4130920	160721114	20194146	30	15653											
KIF13A	63971	broad.mit.edu	37	chr6	17779855	17779855	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatactatttcataggttaCaccacaggaataaaatatat	6	6	1	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr6:17779855C>T	uc003ncg.3	-	32	4012	c.3907G>A	c.(3907-3909)GTA>ATA	p.V1303I	KIF13A_uc003ncf.2_Missense_Mutation_p.V1290I|KIF13A_uc003nch.3_Missense_Mutation_p.V1303I|KIF13A_uc003nci.3_Missense_Mutation_p.V1290I|KIF13A_uc003nce.1_5'Flank	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1303					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TCATAGGTTACACCACAGGAA	0.229													T	17779855	T	T	17779855	3	4	223	1	0	0	0	0	1	0	0	0	8274	478	17	3	1567	3	KIF13A	6	17779855	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08		17779855	153335212	31	15654											
DEF6	50619	broad.mit.edu	37	chr6	35280250	35280250	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcctgcggggcgtgggcCgggacaccctcagcatggcc	17	15	1	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr6:35280250C>T	uc003okk.2	+	4	634	c.595C>T	c.(595-597)CGG>TGG	p.R199W	DEF6_uc010jvs.2_Missense_Mutation_p.R199W|DEF6_uc010jvt.2_Intron	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	199						cytoplasm|nucleus|plasma membrane					0						GGGCGTGGGCCGGGACACCCT	0.652													T	35280250	T	T	35280250	3	4	223	1	0	0	0	0	1	0	0	0	4386	643	23	2	609	2	DEF6	6	35280250	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	17500395	35280250	135834817	32	15655											
MOCS1	4337	broad.mit.edu	37	chr6	39877612	39877612	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcttcctgcccacagcagCcccaatgattctcagcagct	6	17	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr6:39877612C>T	uc003opb.2	-	8	1207	c.1069G>A	c.(1069-1071)GCT>ACT	p.A357T	MOCS1_uc003opa.2_Missense_Mutation_p.A357T|MOCS1_uc003opc.2_Missense_Mutation_p.A357T|MOCS1_uc003opd.2_Missense_Mutation_p.A357T|MOCS1_uc003ope.2_Missense_Mutation_p.A270T	NM_005942	NP_005933	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis-step 1 protein	357	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding	p.A357V(1)		ovary(1)|liver(1)|central_nervous_system(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CCCACAGCAGCCCCAATGATT	0.622													T	39877612	T	T	39877612	3	4	223	1	0	0	0	0	1	0	0	0	9690	739	26	3	96	3	MOCS1	6	39877612	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	4597362	39877612	131237455	33	15656											
KIAA1244	57221	broad.mit.edu	37	chr6	138531138	138531138	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgaatgccgtgaaagtgaCgccttcgctcaacgaggacc	11	12	1	3			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr6:138531138C>T	uc003qhu.2	+	4	311	c.311C>T	c.(310-312)ACG>ATG	p.T104M		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	104					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		GTGAAAGTGACGCCTTCGCTC	0.502													T	138531138	T	T	138531138	3	4	223	1	0	0	0	0	1	0	0	0	8217	536	19	1	325	1	KIAA1244	6	138531138	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	98653526	138531138	32583929	34	15657											
IGF2R	3482	broad.mit.edu	37	chr6	160501272	160501272	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgtagcacaactgcggactAcgacagagaccacgagtggg	14	10	0	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr6:160501272A>G	uc003qta.2	+	39	5946	c.5798A>G	c.(5797-5799)TAC>TGC	p.Y1933C		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1933	13.|Lumenal (Potential).|Fibronectin type-II.				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ACTGCGGACTACGACAGAGAC	0.577													G	160501272	G	G	160501272	3	3	223	1	0	0	0	0	1	0	0	0	7576	391	14	4	5952	4	IGF2R	6	160501272	Missense_Mutation	SNP	A	TCGA-32-1979-01A-01D-1696-08	21970134	160501272	10613795	35	15658											
SCIN	85477	broad.mit.edu	37	chr7	12683930	12683930	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttaaggatccaagaaggCgaggagccaggtgtgtgctc	14	9	0	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr7:12683930C>T	uc003ssn.3	+	12	1959	c.1749C>T	c.(1747-1749)GGC>GGT	p.G583G	SCIN_uc010ktt.2_Intron|SCIN_uc003sso.3_Silent_p.G336G	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	583	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TCCAAGAAGGCGAGGAGCCAG	0.448													T	12683930	T	T	12683930	2	4	223	1	0	0	0	0	0	0	0	1	13905	755	27	1		1	SCIN	7	12683930	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08		12683930	146454733	36	15659											
IKZF1	10320	broad.mit.edu	37	chr7	50467929	50467929	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgccctcggagcgcgaggcGtccccgagcaacagctgcca	14	16	0	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr7:50467929G>A	uc003tow.3	+	9	1332	c.1164G>A	c.(1162-1164)GCG>GCA	p.A388A	IKZF1_uc003tox.3_Silent_p.A346A|IKZF1_uc003toy.3_Silent_p.A346A|IKZF1_uc011kck.1_Silent_p.A301A|IKZF1_uc003toz.3_Silent_p.A358A|IKZF1_uc010kyx.2_Silent_p.A128A|IKZF1_uc003tpa.3_Silent_p.A130A	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	388					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				AGCGCGAGGCGTCCCCGAGCA	0.672			D		ALL								A	50467929	A	A	50467929	2	1	223	1	0	0	0	0	0	0	0	1	7614	1132	40	1		1	IKZF1	7	50467929	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	37783999	50467929	108670734	37	15660											
EGFR	1956	broad.mit.edu	37	chr7	55221765	55221765	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgccccccactcatgctctAcaaccccaccacgtaccaga	4	21	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr7:55221765A>G	uc003tqk.2	+	7	1055	c.809A>G	c.(808-810)TAC>TGC	p.Y270C	EGFR_uc003tqh.2_Missense_Mutation_p.Y270C|EGFR_uc003tqi.2_Missense_Mutation_p.Y270C|EGFR_uc003tqj.2_Missense_Mutation_p.Y270C|EGFR_uc010kzg.1_Missense_Mutation_p.Y225C|EGFR_uc011kco.1_Missense_Mutation_p.Y217C|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	270	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTCATGCTCTACAACCCCACC	0.587		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			G	55221765	G	G	55221765	3	3	223	1	0	0	0	0	1	0	0	0	4967	391	14	4	835	4	EGFR	7	55221765	Missense_Mutation	SNP	A	TCGA-32-1979-01A-01D-1696-08	4753836	55221765	103916898	38	15661											
AZGP1	563	broad.mit.edu	37	chr7	99565820	99565820	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgtatttcaggtatttccGcagagtcgcagggcactcct	11	11	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr7:99565820G>A	uc003ush.2	-	3	615	c.571C>T	c.(571-573)CGG>TGG	p.R191W		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	191					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AGGTATTTCCGCAGAGTCGCA	0.552													A	99565820	A	A	99565820	3	1	223	1	0	0	0	0	1	0	0	0	1239	1086	38	1	333	1	AZGP1	7	99565820	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	44344055	99565820	59572843	39	15662											
OR6V1	346517	broad.mit.edu	37	chr7	142749461	142749461	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaaatctgagccagccctcCgaatttgtcctcttgggctt	9	13	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr7:142749461C>T	uc011ksv.1	+	1	24	c.24C>T	c.(22-24)TCC>TCT	p.S8S		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					GCCAGCCCTCCGAATTTGTCC	0.408													T	142749461	T	T	142749461	2	4	223	1	0	0	0	0	0	0	0	1	11211	639	23	2		2	OR6V1	7	142749461	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08	43183641	142749461	16389202	40	15663											
CNTNAP2	26047	broad.mit.edu	37	chr7	147259237	147259237	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtttgttctagctatctaCgagccttcctgtgaagccta	8	10	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr7:147259237C>T	uc003weu.1	+	12	2301	c.1785C>T	c.(1783-1785)TAC>TAT	p.Y595Y		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	595	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TAGCTATCTACGAGCCTTCCT	0.448										HNSCC(39;0.1)			T	147259237	T	T	147259237	2	4	223	1	0	0	0	0	0	0	0	1	3647	547	19	1		1	CNTNAP2	7	147259237	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08	4509776	147259237	11879426	41	15664											
SSPO	23145	broad.mit.edu	37	chr7	149489760	149489760	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtccttccggagctccaacaAcccccgcccctccggccgag	9	21	0	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr7:149489760A>C	uc010lpk.2	+	39	5816	c.5816A>C	c.(5815-5817)AAC>ACC	p.N1939T		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1939	TSP type-1 3.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGCTCCAACAACCCCCGCCCC	0.692													C	149489760	C	C	149489760	3	2	223	1	0	0	0	0	1	0	0	0	15188	43	2	5	5962	5	SSPO	7	149489760	Missense_Mutation	SNP	A	TCGA-32-1979-01A-01D-1696-08	2230523	149489760	9648903	42	15665											
PRKDC	5591	broad.mit.edu	37	chr8	48805878	48805878	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagccacccccctcaaagGtgttgatgagaaaagagaca	9	12	1	3			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr8:48805878G>A	uc003xqi.2	-	31	3725	c.3668C>T	c.(3667-3669)ACC>ATC	p.T1223I	PRKDC_uc003xqj.2_Missense_Mutation_p.T1223I|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1223					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCCCTCAAAGGTGTTGATGAG	0.522								NHEJ					A	48805878	A	A	48805878	3	1	223	1	0	0	0	0	1	0	0	0	12521	1261	44	3	8941	3	PRKDC	8	48805878	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08		48805878	97558144	43	15666											
PENK	5179	broad.mit.edu	37	chr8	57353950	57353950	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcaggaaacctccataccGtttctggtagtccatccacc	6	15	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr8:57353950G>A	uc003xsz.2	-	2	766	c.685C>T	c.(685-687)CGG>TGG	p.R229W	PENK_uc003xta.3_Missense_Mutation_p.R229W	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	229					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CCTCCATACCGTTTCTGGTAG	0.517													A	57353950	A	A	57353950	3	1	223	1	0	0	0	0	1	0	0	0	11727	1144	40	1	122	1	PENK	8	57353950	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	8548072	57353950	89010072	44	15667											
OXR1	55074	broad.mit.edu	37	chr8	107722899	107722899	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	catcgattacataagttcttGtgtctcagagttggaaaacc	8	8	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr8:107722899G>T	uc011lht.1	+	9	1776	c.1677G>T	c.(1675-1677)TTG>TTT	p.L559F	OXR1_uc003ymf.2_Missense_Mutation_p.L558F|OXR1_uc011lhu.1_Missense_Mutation_p.L551F|OXR1_uc010mcg.2_Intron|OXR1_uc010mch.2_Missense_Mutation_p.L256F	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	559					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			ATAAGTTCTTGTGTCTCAGAG	0.358													T	107722899	T	T	107722899	3	4	223	1	0	0	0	0	1	0	0	0	11334	1368	48	5	1911	5	OXR1	8	107722899	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	50368949	107722899	38641123	45	15668											
ST3GAL1	6482	broad.mit.edu	37	chr8	134488106	134488106	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	caggtgcaaggcctgtgcttGatcagtctcttcaggttctc	11	11	4	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr8:134488106G>C	uc003yuk.2	-	5	991	c.162C>G	c.(160-162)ATC>ATG	p.I54M	ST3GAL1_uc003yum.2_Missense_Mutation_p.I54M	NM_173344	NP_775479	Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	54	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			GCCTGTGCTTGATCAGTCTCT	0.597													C	134488106	C	C	134488106	3	2	223	1	0	0	0	0	1	0	0	0	15213	1280	45	5	884	5	ST3GAL1	8	134488106	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	26765207	134488106	11875916	46	15669											
BNC2	54796	broad.mit.edu	37	chr9	16436735	16436735	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtttgcactgtggcgattaCgacttcggagggagctaaag	15	7	0	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr9:16436735C>T	uc003zml.2	-	6	1597	c.1457G>A	c.(1456-1458)CGT>CAT	p.R486H	BNC2_uc011lmw.1_Missense_Mutation_p.R391H|BNC2_uc003zmm.2_Missense_Mutation_p.R444H|BNC2_uc003zmq.1_Missense_Mutation_p.R500H|BNC2_uc003zmr.1_Missense_Mutation_p.R523H|BNC2_uc003zmp.1_Missense_Mutation_p.R514H|BNC2_uc010mij.1_Missense_Mutation_p.R408H|BNC2_uc011lmv.1_Missense_Mutation_p.R312H|BNC2_uc003zmo.1_Missense_Mutation_p.R408H|BNC2_uc003zmj.2_Missense_Mutation_p.R251H|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.R251H|BNC2_uc003zmn.1_Missense_Mutation_p.R251H	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	486					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GTGGCGATTACGACTTCGGAG	0.463													T	16436735	T	T	16436735	3	4	223	1	0	0	0	0	1	0	0	0	1475	536	19	1	1850	1	BNC2	9	16436735	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08		16436735	124776696	47	15670											
C9orf64	84267	broad.mit.edu	37	chr9	86559803	86559803	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	taatcagcaaacatggtgatActggagatgtccttgaagca	10	7	1	3			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr9:86559803A>T	uc004anb.2	-	3	947	c.699T>A	c.(697-699)AGT>AGA	p.S233R	C9orf64_uc004anc.2_Missense_Mutation_p.S92R	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	233											0						ACATGGTGATACTGGAGATGT	0.428													T	86559803	T	T	86559803	3	4	223	1	0	0	0	0	1	0	0	0	2489	388	14	5	334	5	C9orf64	9	86559803	Missense_Mutation	SNP	A	TCGA-32-1979-01A-01D-1696-08	70123068	86559803	54653628	48	15671											
HDHD3	81932	broad.mit.edu	37	chr9	116136378	116136378	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgagcatcctggacacccGccaggtggaaggtctgcagg	14	13	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr9:116136378G>A	uc004bhi.1	-	2	1041	c.257C>T	c.(256-258)GCG>GTG	p.A86V	HDHD3_uc004bhj.2_Missense_Mutation_p.A86V|HDHD3_uc004bhk.2_Missense_Mutation_p.A86V	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	86							phosphoglycolate phosphatase activity|protein binding				0						CTGGACACCCGCCAGGTGGAA	0.617													A	116136378	A	A	116136378	3	1	223	1	0	0	0	0	1	0	0	0	7024	1087	38	1	502	1	HDHD3	9	116136378	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	29576575	116136378	25077053	49	15672											
FAM129B	64855	broad.mit.edu	37	chr9	130272452	130272452	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcttgtcaatgccgccctcGttgatgacgttcaggttcat	10	11	3	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr9:130272452G>A	uc004brh.2	-	9	1336	c.1134C>T	c.(1132-1134)AAC>AAT	p.N378N	FAM129B_uc004bri.2_Silent_p.N365N|FAM129B_uc004brj.3_Silent_p.N378N	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	378							protein binding				0						TGCCGCCCTCGTTGATGACGT	0.637													A	130272452	A	A	130272452	2	1	223	1	0	0	0	0	0	0	0	1	5437	1136	40	1		1	FAM129B	9	130272452	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	14136074	130272452	10940979	50	15673											
C9orf167	54863	broad.mit.edu	37	chr9	140173549	140173549	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgggcttccaagttctcaaCgctatcgagaacctggacga	11	11	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr9:140173549C>T	uc004cmn.2	+	2	525	c.408C>T	c.(406-408)AAC>AAT	p.N136N	C9orf167_uc011mew.1_5'Flank	NM_017723	NP_060193	Q9NXH8	CI167_HUMAN	hypothetical protein LOC54863	136	Helical; (Potential).				chaperone mediated protein folding requiring cofactor	integral to membrane	ATP binding|nucleoside-triphosphatase activity			pancreas(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.07e-05)|Epithelial(140;0.000728)		AAGTTCTCAACGCTATCGAGA	0.662													T	140173549	T	T	140173549	2	4	223	1	0	0	0	0	0	0	0	1	2468	535	19	1		1	C9orf167	9	140173549	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08	9901097	140173549	1039882	51	15674											
RET	5979	broad.mit.edu	37	chr10	43606701	43606701	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccaggcattcagtggcatcaAcgtccagtacaagctgcatt	9	12	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr10:43606701A>T	uc001jal.2	+	7	1500	c.1310A>T	c.(1309-1311)AAC>ATC	p.N437I	RET_uc001jak.1_Missense_Mutation_p.N437I|RET_uc010qez.1_Missense_Mutation_p.N183I	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	437	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	AGTGGCATCAACGTCCAGTAC	0.582		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				T	43606701	T	T	43606701	3	4	223	1	0	0	0	0	1	0	0	0	13235	43	2	5	1336	5	RET	10	43606701	Missense_Mutation	SNP	A	TCGA-32-1979-01A-01D-1696-08		43606701	91928046	52	15675											
DNMBP	23268	broad.mit.edu	37	chr10	101716663	101716663	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctggaaaaatgcctcttcGgccctctaactccccttcaa	5	15	4	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr10:101716663G>A	uc001kqj.2	-	4	660	c.568C>T	c.(568-570)CGA>TGA	p.R190*	NCRNA00093_uc001kqk.1_RNA	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	190	SH3 3.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		ATGCCTCTTCGGCCCTCTAAC	0.488													A	101716663	A	A	101716663	4	1	223	1	0	0	0	0	0	1	0	0	4674	1124	39	2	4221	2	DNMBP	10	101716663	Nonsense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	58109962	101716663	33818084	53	15676											
ATHL1	80162	broad.mit.edu	37	chr11	294169	294169	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catggggggcttcctgcaggCggtggtcttcgggtgcacgg	19	10	1	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr11:294169C>T	uc010qvu.1	+	12	1896	c.1781C>T	c.(1780-1782)GCG>GTG	p.A594V	ATHL1_uc001lor.3_Missense_Mutation_p.A346V|ATHL1_uc001lou.3_Missense_Mutation_p.A169V|ATHL1_uc001lov.3_Missense_Mutation_p.A55V	NM_025092	NP_079368	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1	594					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			liver(1)|central_nervous_system(1)|skin(1)	3		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		TTCCTGCAGGCGGTGGTCTTC	0.652													T	294169	T	T	294169	3	4	223	1	0	0	0	0	1	0	0	0	1104	768	27	1	1823	1	ATHL1	11	294169	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08		294169	134712347	54	15677											
TNNT3	7140	broad.mit.edu	37	chr11	1956149	1956149	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgaaacgccagaaatatgaCgtgagtcccggcacctccgg	11	13	0	4			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr11:1956149C>T	uc001luu.3	+	14	893	c.681C>T	c.(679-681)GAC>GAT	p.D227D	TNNT3_uc001lun.2_Silent_p.D123D|TNNT3_uc001luw.3_Silent_p.D219D|TNNT3_uc001luo.3_Silent_p.D219D|TNNT3_uc001lup.3_Silent_p.D225D|TNNT3_uc001luq.3_Silent_p.D219D|TNNT3_uc001lur.2_Silent_p.D219D|TNNT3_uc010qxf.1_Silent_p.D225D|TNNT3_uc010qxg.1_Silent_p.D159D	NM_006757	NP_006748	P45378	TNNT3_HUMAN	troponin T3, skeletal, fast isoform 1	238					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		AGAAATATGACGTGAGTCCCG	0.617													T	1956149	T	T	1956149	2	4	223	1	0	0	0	0	0	0	0	1	16329	550	19	1		1	TNNT3	11	1956149	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08	1661980	1956149	133050367	55	15678											
SLC6A5	9152	broad.mit.edu	37	chr11	20648387	20648387	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagaaactcacggatgccaCggtgggcttctaattttatc	11	9	2	1	rs146647574	byFrequency	TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr11:20648387C>T	uc001mqd.2	+	8	1667	c.1394C>T	c.(1393-1395)ACG>ATG	p.T465M	SLC6A5_uc009yic.2_Missense_Mutation_p.T230M	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	465					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	ACGGATGCCACGGTGGGCTTC	0.562													T	20648387	T	T	20648387	3	4	223	1	0	0	0	0	1	0	0	0	14687	550	19	1	1424	1	SLC6A5	11	20648387	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	18692238	20648387	114358129	56	15679											
CHST1	8534	broad.mit.edu	37	chr11	45671489	45671489	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgttctggatccagcgggCcacgtggctgtccagcggga	16	11	1	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr11:45671489C>T	uc001mys.1	-	4	1656	c.985G>A	c.(985-987)GCC>ACC	p.A329T		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	329	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		ATCCAGCGGGCCACGTGGCTG	0.632													T	45671489	T	T	45671489	3	4	223	1	0	0	0	0	1	0	0	0	3397	739	26	3	254	3	CHST1	11	45671489	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	25023102	45671489	89335027	57	15680											
TCN1	6947	broad.mit.edu	37	chr11	59629106	59629106	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aacagacacaaggccaaaacGtccaggctgagctggtagta	11	10	0	2	rs139772818	by1000genomes	TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr11:59629106G>C	uc001noj.2	-	4	548	c.450C>G	c.(448-450)GAC>GAG	p.D150E		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	150					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGGCCAAAACGTCCAGGCTGA	0.438													C	59629106	C	C	59629106	3	2	223	1	0	0	0	0	1	0	0	0	15703	1136	40	5	875	5	TCN1	11	59629106	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	13957617	59629106	75377410	58	15681											
KDELC2	143888	broad.mit.edu	37	chr11	108352840	108352840	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	caacatctcttgaatccagaGagccacaccatgaaatgata	6	11	1	4			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr11:108352840G>C	uc001pkj.2	-	4	860	c.794C>G	c.(793-795)TCT>TGT	p.S265C	KDELC2_uc001pki.2_Missense_Mutation_p.S209C	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	265						endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		TGAATCCAGAGAGCCACACCA	0.453													C	108352840	C	C	108352840	3	2	223	1	0	0	0	0	1	0	0	0	8118	942	33	5	749	5	KDELC2	11	108352840	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	48723734	108352840	26653676	59	15682											
AMICA1	120425	broad.mit.edu	37	chr11	118085599	118085599	+	Translation_Start_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catgctgctctcaactttcaAatcttaagataaaagaacaa	4	9	3	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr11:118085599A>T	uc001psk.2	-	2	157	c.-17T>A	c.(-19--15)ATTTG>ATATG		AMICA1_uc001psh.2_5'Flank|AMICA1_uc009yzw.1_5'Flank|AMICA1_uc001psi.2_5'Flank|AMICA1_uc001psj.2_Translation_Start_Site|AMICA1_uc010rxw.1_Intron|AMICA1_uc010rxx.1_Translation_Start_Site|AMICA1_uc001psl.1_5'Flank	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen						blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TCAACTTTCAAATCTTAAGAT	0.299													T	118085599	T	T	118085599	1	4	223	1	0	0	0	0	0	0	0	0	574	29	1	5		5	AMICA1	11	118085599	Translation_Start_Site	SNP	A	TCGA-32-1979-01A-01D-1696-08	9732759	118085599	16920917	60	15683											
ALG10B	144245	broad.mit.edu	37	chr12	38714180	38714180	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcatctgggctgtcttctGtgcagggaatgtcattgcac	11	9	5	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr12:38714180G>A	uc001rln.3	+	3	726	c.587G>A	c.(586-588)TGT>TAT	p.C196Y	ALG10B_uc001rlo.3_Missense_Mutation_p.C166Y|ALG10B_uc010skk.1_Missense_Mutation_p.C136Y	NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	asparagine-linked glycosylation 10 homolog B	196	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|skin(1)	3	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				GCTGTCTTCTGTGCAGGGAAT	0.398													A	38714180	A	A	38714180	3	1	223	1	0	0	0	0	1	0	0	0	512	1377	48	3	597	3	ALG10B	12	38714180	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08		38714180	95137715	61	15684											
MYO1A	4640	broad.mit.edu	37	chr12	57442017	57442017	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatctccttgttttcatagcGaagctgaagattcttgagca	8	8	3	3			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr12:57442017G>A	uc001smw.3	-	2	334	c.91C>T	c.(91-93)CGC>TGC	p.R31C	MYO1A_uc010sqz.1_5'Flank|MYO1A_uc009zpd.2_Missense_Mutation_p.R31C	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	31	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						TTTTCATAGCGAAGCTGAAGA	0.542													A	57442017	A	A	57442017	3	1	223	1	0	0	0	0	1	0	0	0	10068	1058	37	2	3148	2	MYO1A	12	57442017	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	18727837	57442017	76409878	62	15685											
SLC17A8	246213	broad.mit.edu	37	chr12	100787226	100787226	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagagtgcattacggatgcGtcatgtgtgtcagaattctg	12	8	3	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr12:100787226G>A	uc010svi.1	+	4	866	c.553G>A	c.(553-555)GTC>ATC	p.V185I	SLC17A8_uc009ztx.2_Missense_Mutation_p.V185I	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	185	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TTACGGATGCGTCATGTGTGT	0.448													A	100787226	A	A	100787226	3	1	223	1	0	0	0	0	1	0	0	0	14423	1145	40	1	567	1	SLC17A8	12	100787226	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	43345209	100787226	33064669	63	15686											
CLEC14A	161198	broad.mit.edu	37	chr14	38724727	38724727	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtacttgcacaggtagccGttggcgcgcaggtggcatcg	16	10	0	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr14:38724727G>A	uc001wum.1	-	1	848	c.501C>T	c.(499-501)AAC>AAT	p.N167N		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	167	Extracellular (Potential).|C-type lectin.					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		ACAGGTAGCCGTTGGCGCGCA	0.577													A	38724727	A	A	38724727	2	1	223	1	0	0	0	0	0	0	0	1	3499	1136	40	1		1	CLEC14A	14	38724727	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08		38724727	68624813	64	15687											
SOS2	6655	broad.mit.edu	37	chr14	50626273	50626273	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttcctcagagtcttttacTacaaaacgatatacttcagg	5	9	3	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr14:50626273T>C	uc001wxs.3	-	10	1826	c.1728A>G	c.(1726-1728)GTA>GTG	p.V576V	SOS2_uc010tql.1_Silent_p.V543V|SOS2_uc010tqm.1_RNA|SOS2_uc001wxt.2_Silent_p.V264V	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	576					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					AGTCTTTTACTACAAAACGAT	0.333													C	50626273	C	C	50626273	2	2	223	1	0	0	0	0	0	0	0	1	14937	1509	53	4		4	SOS2	14	50626273	Silent	SNP	T	TCGA-32-1979-01A-01D-1696-08	11901546	50626273	56723267	65	15688											
C14orf145	145508	broad.mit.edu	37	chr14	81223256	81223256	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttgctttctgctaaccagcGatgtgggtcataatgtatat	9	8	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr14:81223256G>A	uc001xux.2	-	17	2764	c.2593C>T	c.(2593-2595)CGC>TGC	p.R865C	C14orf145_uc010asz.1_RNA	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	865						centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		GCTAACCAGCGATGTGGGTCA	0.289													A	81223256	A	A	81223256	3	1	223	1	0	0	0	0	1	0	0	0	1749	1058	37	2	723	2	C14orf145	14	81223256	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	30596983	81223256	26126284	66	15689											
KIF26A	26153	broad.mit.edu	37	chr14	104639702	104639702	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagctgcgggcacccacggcCgagaaggcggctttctacct	14	14	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr14:104639702C>T	uc001yos.3	+	9	1719	c.1719C>T	c.(1717-1719)GCC>GCT	p.A573A		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	573	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CACCCACGGCCGAGAAGGCGG	0.692													T	104639702	T	T	104639702	2	4	223	1	0	0	0	0	0	0	0	1	8294	639	23	2		2	KIF26A	14	104639702	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08	23416446	104639702	2709838	67	15690											
SH3GL3	6457	broad.mit.edu	37	chr15	84237359	84237359	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccacaggatacccgcagaCggaaggcttgctgggggact	15	11	0	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr15:84237359C>T	uc002bjw.2	+	4	461	c.266C>T	c.(265-267)ACG>ATG	p.T89M	SH3GL3_uc010uot.1_Missense_Mutation_p.T89M|SH3GL3_uc002bjx.2_Missense_Mutation_p.T20M|SH3GL3_uc002bju.2_Missense_Mutation_p.T97M|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	89	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						TACCCGCAGACGGAAGGCTTG	0.507													T	84237359	T	T	84237359	3	4	223	1	0	0	0	0	1	0	0	0	14252	536	19	1	280	1	SH3GL3	15	84237359	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08		84237359	18294033	68	15691											
UNC45A	55898	broad.mit.edu	37	chr15	91483616	91483616	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agtaatggggttcagctcttGcaacgtttactggacatggg	13	7	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr15:91483616G>C	uc002bqg.2	+	6	940	c.600G>C	c.(598-600)TTG>TTC	p.L200F	UNC45A_uc002bqd.2_Missense_Mutation_p.L185F|UNC45A_uc010uqo.1_Missense_Mutation_p.L192F|UNC45A_uc010uqp.1_RNA|UNC45A_uc010uqq.1_Missense_Mutation_p.L200F	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	200					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TTCAGCTCTTGCAACGTTTAC	0.567													C	91483616	C	C	91483616	3	2	223	1	0	0	0	0	1	0	0	0	16985	1310	46	5	622	5	UNC45A	15	91483616	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	7246257	91483616	11047776	69	15692											
SEZ6L2	26470	broad.mit.edu	37	chr16	29884701	29884701	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtagtggtgcttgtacagcGtctggtagccattctcggga	15	8	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr16:29884701G>A	uc002duq.3	-	14	2588	c.2348C>T	c.(2347-2349)ACG>ATG	p.T783M	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.T713M|SEZ6L2_uc002dur.3_Missense_Mutation_p.T713M|SEZ6L2_uc002dus.3_Missense_Mutation_p.T669M|SEZ6L2_uc010vec.1_Missense_Mutation_p.T783M|SEZ6L2_uc010ved.1_Missense_Mutation_p.T739M	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	783	Sushi 5.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CTTGTACAGCGTCTGGTAGCC	0.622													A	29884701	A	A	29884701	3	1	223	1	0	0	0	0	1	0	0	0	14144	1145	40	1	443	1	SEZ6L2	16	29884701	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08		29884701	60470052	70	15693											
MYH1	4619	broad.mit.edu	37	chr17	10406199	10406199	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agcttagcaatggtttcatcCagacccgccatctcttctgt	7	13	3	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr17:10406199C>A	uc002gmo.2	-	24	3061	c.2967G>T	c.(2965-2967)CTG>CTT	p.L989L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	989	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TGGTTTCATCCAGACCCGCCA	0.507													A	10406199	A	A	10406199	2	1	223	1	0	0	0	0	0	0	0	1	10029	581	21	5		5	MYH1	17	10406199	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08		10406199	70789011	71	15694											
SLFN13	146857	broad.mit.edu	37	chr17	33767745	33767745	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttccaggcctgagaatcgccGgacactgtccaacacaatgt	9	13	0	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr17:33767745G>A	uc002hjk.1	-	4	2893	c.2563C>T	c.(2563-2565)CGG>TGG	p.R855W	SLFN13_uc010wch.1_Missense_Mutation_p.R855W|SLFN13_uc002hjl.2_Missense_Mutation_p.R855W|SLFN13_uc010ctt.2_Missense_Mutation_p.R537W|SLFN13_uc002hjm.2_Missense_Mutation_p.R524W	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	855						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GAGAATCGCCGGACACTGTCC	0.483													A	33767745	A	A	33767745	3	1	223	1	0	0	0	0	1	0	0	0	14736	1115	39	2	134	2	SLFN13	17	33767745	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	23361546	33767745	47427465	72	15695											
KRTAP1-3	81850	broad.mit.edu	37	chr17	39190659	39190659	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggcagcaggaggcctcggCgtggtgcagctggcagcagg	20	11	0	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr17:39190659C>T	uc002hvv.2	-	1	449	c.415G>A	c.(415-417)GCC>ACC	p.A139T		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	149						extracellular region|keratin filament	structural constituent of epidermis				0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GAGGCCTCGGCGTGGTGCAGC	0.652													T	39190659	T	T	39190659	3	4	223	1	0	0	0	0	1	0	0	0	8503	768	27	1	92	1	KRTAP1-3	17	39190659	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	5422914	39190659	42004551	73	15696											
OR4D2	124538	broad.mit.edu	37	chr17	56247206	56247206	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacccatgtactttctgctcCgaaacctggctgtcctagac	7	15	1	1	rs148589207		TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr17:56247206C>T	uc010wnp.1	+	1	190	c.190C>T	c.(190-192)CGA>TGA	p.R64*		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						CTTTCTGCTCCGAAACCTGGC	0.483													T	56247206	T	T	56247206	4	4	223	1	0	0	0	0	0	1	0	0	11056	644	23	2	192	2	OR4D2	17	56247206	Nonsense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	17056547	56247206	24948004	74	15697											
EPB41L3	23136	broad.mit.edu	37	chr18	5395100	5395100	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtctgcatcccccgtgatgActattcgcttctcaattctt	6	13	3	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr18:5395100A>G	uc002kmt.1	-	21	3205	c.3119T>C	c.(3118-3120)GTC>GCC	p.V1040A	EPB41L3_uc010wzh.1_Missense_Mutation_p.V871A|EPB41L3_uc002kmu.1_Missense_Mutation_p.V818A|EPB41L3_uc010dkq.1_Missense_Mutation_p.V709A|EPB41L3_uc002kms.1_Missense_Mutation_p.V275A|EPB41L3_uc010wze.1_Missense_Mutation_p.V345A|EPB41L3_uc010wzf.1_Missense_Mutation_p.V337A|EPB41L3_uc010wzg.1_Missense_Mutation_p.V312A|EPB41L3_uc010dkr.2_Missense_Mutation_p.V432A	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1040	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CCCCGTGATGACTATTCGCTT	0.448													G	5395100	G	G	5395100	3	3	223	1	0	0	0	0	1	0	0	0	5154	275	10	4	152	4	EPB41L3	18	5395100	Missense_Mutation	SNP	A	TCGA-32-1979-01A-01D-1696-08		5395100	72682148	75	15698											
MC5R	4161	broad.mit.edu	37	chr18	13826447	13826447	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgcccggggccagctctgCgcggcagaggaccagcatgc	15	15	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr18:13826447C>T	uc010xaf.1	+	1	683	c.683C>T	c.(682-684)GCG>GTG	p.A228V		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	228	Cytoplasmic (Potential).			ALPGASSARQRTSM -> LCPGPALRGRGPAW (in Ref. 1).	G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						GCCAGCTCTGCGCGGCAGAGG	0.612													T	13826447	T	T	13826447	3	4	223	1	0	0	0	0	1	0	0	0	9367	768	27	1	685	1	MC5R	18	13826447	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	8431347	13826447	64250801	76	15699											
CDH19	28513	broad.mit.edu	37	chr18	64218345	64218345	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acttactttctttaaatataGgcttattgtcattaacatct	3	7	3	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr18:64218345G>A	uc002lkc.1	-	5	899	c.761C>T	c.(760-762)CCT>CTT	p.P254L	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.P254L|CDH19_uc002lkd.2_Missense_Mutation_p.P254L	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	254	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TTTAAATATAGGCTTATTGTC	0.294													A	64218345	A	A	64218345	3	1	223	1	0	0	0	0	1	0	0	0	3104	1000	35	3	1589	3	CDH19	18	64218345	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	50391898	64218345	13858903	77	15700											
NFIX	4784	broad.mit.edu	37	chr19	13189498	13189498	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctctcagggcagctccccgCgcatggctttcacccaccac	8	20	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:13189498C>T	uc010xmx.1	+	7	1104	c.1051C>T	c.(1051-1053)CGC>TGC	p.R351C	NFIX_uc002mwd.2_Missense_Mutation_p.R343C|NFIX_uc002mwe.2_Missense_Mutation_p.R335C|NFIX_uc002mwf.2_Intron|NFIX_uc002mwg.1_Missense_Mutation_p.R342C			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	343					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			CAGCTCCCCGCGCATGGCTTT	0.642													T	13189498	T	T	13189498	3	4	223	1	0	0	0	0	1	0	0	0	10374	768	27	1	1053	1	NFIX	19	13189498	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08		13189498	45939485	78	15701											
CYP4F22	126410	broad.mit.edu	37	chr19	15648390	15648390	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgacaagtggagccggcacCgtcgcctgctgacacccgcc	13	16	0	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:15648390C>T	uc002nbh.3	+	6	633	c.466C>T	c.(466-468)CGT>TGT	p.R156C		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	156						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						GAGCCGGCACCGTCGCCTGCT	0.542													T	15648390	T	T	15648390	3	4	223	1	0	0	0	0	1	0	0	0	4189	652	23	2	480	2	CYP4F22	19	15648390	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	2458892	15648390	43480593	79	15702											
UPF1	5976	broad.mit.edu	37	chr19	18968250	18968250	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgggcatccggcccatccGcctgcaggtccagtaccgga	13	16	0	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:18968250G>A	uc002nkg.2	+	15	2398	c.2123G>A	c.(2122-2124)CGC>CAC	p.R708H	UPF1_uc002nkf.2_Missense_Mutation_p.R697H|UPF1_uc002nkh.2_5'Flank	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	708					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CGGCCCATCCGCCTGCAGGTC	0.642													A	18968250	A	A	18968250	3	1	223	1	0	0	0	0	1	0	0	0	17000	1087	38	1	2148	1	UPF1	19	18968250	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	3319860	18968250	40160733	80	15703											
ATP13A1	57130	broad.mit.edu	37	chr19	19758484	19758484	+	Frame_Shift_Del	DEL	C	-	-													tcctggaggtggctctgatgCcactgttgctcagggttggg							TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:19758484delC	uc002nnh.3	-	20	2745	c.2717delG	c.(2716-2718)GGCfs	p.G906fs	ATP13A1_uc002nne.2_Frame_Shift_Del_p.G46fs|ATP13A1_uc002nnf.3_Frame_Shift_Del_p.G274fs|ATP13A1_uc002nng.2_Frame_Shift_Del_p.G788fs	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	ATPase type 13A1	906	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(3)|large_intestine(2)|central_nervous_system(1)	6						GGCTCTGATGCCACTGTTGCT	0.697													-	19758484	-	-	19758484	7	5	223	1	0	1	0	1	0	0	0	0	1123	739	26	0	925	0	ATP13A1	19	19758484	Frame_Shift_Del	DEL	C	TCGA-32-1979-01A-01D-1696-08	790234	19758484	39370499	81	15704											
ZNF676	163223	broad.mit.edu	37	chr19	22363727	22363727	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtattaagggttgagacGctactaaatcctttgccaca	9	8	0	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:22363727G>A	uc002nqs.1	-	3	1110	c.792C>T	c.(790-792)AGC>AGT	p.S264S		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	264	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GGGTTGAGACGCTACTAAATC	0.398													A	22363727	A	A	22363727	2	1	223	1	0	0	0	0	0	0	0	1	18080	1078	38	1		1	ZNF676	19	22363727	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	2605243	22363727	36765256	82	15705											
FAM187B	148109	broad.mit.edu	37	chr19	35719014	35719014	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagctcaggccgcaagcgGctagaccacaccagcacctc	10	17	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:35719014G>A	uc002nyk.1	-	1	615	c.570C>T	c.(568-570)AGC>AGT	p.S190S		NM_152481	NP_689694	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	190	Extracellular (Potential).					integral to membrane				ovary(2)	2						GCCGCAAGCGGCTAGACCACA	0.577													A	35719014	A	A	35719014	2	1	223	1	0	0	0	0	0	0	0	1	5513	1194	42	3		3	FAM187B	19	35719014	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	13355287	35719014	23409969	83	15706											
RYR1	6261	broad.mit.edu	37	chr19	39051893	39051893	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacgcgacatcggcttcaaCgtggcggtgctgctgaccaa	13	13	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:39051893C>T	uc002oit.2	+	90	12553	c.12423C>T	c.(12421-12423)AAC>AAT	p.N4141N	RYR1_uc002oiu.2_Silent_p.N4136N|RYR1_uc002oiv.1_Silent_p.N1050N	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4141					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCGGCTTCAACGTGGCGGTGC	0.592													T	39051893	T	T	39051893	2	4	223	1	0	0	0	0	0	0	0	1	13768	535	19	1		1	RYR1	19	39051893	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08	3332879	39051893	20077090	84	15707											
CYP2B6	1555	broad.mit.edu	37	chr19	41512823	41512823	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcctaggggccctcatggaCcccaccttcctcttccagtc	7	18	2	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:41512823C>T	uc002opr.1	+	4	505	c.498C>T	c.(496-498)GAC>GAT	p.D166D	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Intron	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	166					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CCCTCATGGACCCCACCTTCC	0.512													T	41512823	T	T	41512823	2	4	223	1	0	0	0	0	0	0	0	1	4164	506	18	3		3	CYP2B6	19	41512823	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08	2460930	41512823	17616160	85	15708											
MYH14	79784	broad.mit.edu	37	chr19	50812362	50812362	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggccgccggaggctgcagcGtgagctggaagatgtcacag	17	11	1	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:50812362G>A	uc002prr.1	+	40	5812	c.5765G>A	c.(5764-5766)CGT>CAT	p.R1922H	MYH14_uc010enu.1_Missense_Mutation_p.R1963H|MYH14_uc002prq.1_Missense_Mutation_p.R1930H|MYH14_uc010ycb.1_Missense_Mutation_p.R273H|MYH14_uc002prs.1_Missense_Mutation_p.R273H	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1922	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		AGGCTGCAGCGTGAGCTGGAA	0.632													A	50812362	A	A	50812362	3	1	223	1	0	0	0	0	1	0	0	0	10033	1145	40	1	6050	1	MYH14	19	50812362	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	9299539	50812362	8316621	86	15709											
ZNF135	7694	broad.mit.edu	37	chr19	58579130	58579130	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcagagcacactcctgacCgagcatcggaggattcacac	10	13	2	2	rs141591921		TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr19:58579130C>T	uc010yhq.1	+	5	1410	c.1314C>T	c.(1312-1314)ACC>ACT	p.T438T	ZNF135_uc002qre.2_Silent_p.T426T|ZNF135_uc002qrd.1_Intron|ZNF135_uc002qrf.2_Silent_p.T384T|ZNF135_uc002qrg.2_Silent_p.T396T|ZNF135_uc010yhr.1_Silent_p.T247T	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	438					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CACTCCTGACCGAGCATCGGA	0.547													T	58579130	T	T	58579130	2	4	223	1	0	0	0	0	0	0	0	1	17722	639	23	2		2	ZNF135	19	58579130	Silent	SNP	C	TCGA-32-1979-01A-01D-1696-08	7766768	58579130	549853	87	15710											
RSPO4	343637	broad.mit.edu	37	chr20	944738	944738	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtgcaggggctccagccGccccagggacccagttcaca	13	15	1	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr20:944738G>A	uc002wej.2	-	4	532	c.435C>T	c.(433-435)GGC>GGT	p.G145G	RSPO4_uc002wek.2_Intron	NM_001029871	NP_001025042	Q2I0M5	RSPO4_HUMAN	R-spondin family, member 4 isoform 1 precursor	145	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding				0						GGCTCCAGCCGCCCCAGGGAC	0.597													A	944738	A	A	944738	2	1	223	1	0	0	0	0	0	0	0	1	13712	1074	38	1		1	RSPO4	20	944738	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08		944738	62080782	88	15711											
FAM83C	128876	broad.mit.edu	37	chr20	33880014	33880014	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccagcggtgagctctcccGccaccacggcagcttcagct	10	18	2	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr20:33880014G>A	uc010zux.1	-	1	212	c.94C>T	c.(94-96)CGG>TGG	p.R32W	FAM83C_uc002xcb.1_5'UTR	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	32										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GAGCTCTCCCGCCACCACGGC	0.746													A	33880014	A	A	33880014	3	1	223	1	0	0	0	0	1	0	0	0	5635	1086	38	1	2165	1	FAM83C	20	33880014	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	32935276	33880014	29145506	89	15712											
HNF4A	3172	broad.mit.edu	37	chr20	43052742	43052742	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggactacatcaacgaccGccagtatgactcgcgtggcc	12	13	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr20:43052742G>A	uc002xma.2	+	8	1066	c.977G>A	c.(976-978)CGC>CAC	p.R326H	HNF4A_uc002xlt.2_Missense_Mutation_p.R304H|HNF4A_uc002xlu.2_Missense_Mutation_p.R304H|HNF4A_uc002xlv.2_Missense_Mutation_p.R304H|HNF4A_uc002xly.2_Missense_Mutation_p.R326H|HNF4A_uc002xlz.2_Missense_Mutation_p.R326H|HNF4A_uc010ggq.2_Missense_Mutation_p.R319H	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	326					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			ATCAACGACCGCCAGTATGAC	0.582													A	43052742	A	A	43052742	3	1	223	1	0	0	0	0	1	0	0	0	7253	1087	38	1	1060	1	HNF4A	20	43052742	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08	9172728	43052742	19972778	90	15713											
SEMG1	6406	broad.mit.edu	37	chr20	43837052	43837052	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagaaagatgtatcccaaCgcagtatttatagccaaact	7	9	0	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr20:43837052C>T	uc002xni.2	+	2	1171	c.1114C>T	c.(1114-1116)CGC>TGC	p.R372C	SEMG1_uc002xnj.2_Missense_Mutation_p.R312C|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	372	58 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				TGTATCCCAACGCAGTATTTA	0.418													T	43837052	T	T	43837052	3	4	223	1	0	0	0	0	1	0	0	0	14044	536	19	1	1120	1	SEMG1	20	43837052	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	784310	43837052	19188468	91	15714											
CBR1	873	broad.mit.edu	37	chr21	37442646	37442646	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgccctgcgcgacttcctgcGcaaggagtacgggggcctgg	16	14	0	0			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr21:37442646G>A	uc002yvb.1	+	1	362	c.233G>A	c.(232-234)CGC>CAC	p.R78H	uc011aea.1_RNA|SETD4_uc002yva.2_Intron|CBR1_uc010gmx.1_Missense_Mutation_p.R78H|CBR1_uc010gmy.1_Missense_Mutation_p.R78H	NM_001757	NP_001748	P16152	CBR1_HUMAN	carbonyl reductase 1	78					drug metabolic process|vitamin K metabolic process	cytoplasm	15-hydroxyprostaglandin dehydrogenase (NADP+) activity|carbonyl reductase (NADPH) activity|prostaglandin-E2 9-reductase activity|protein binding				0					Acetohexamide(DB00414)|Lubiprostone(DB01046)	GACTTCCTGCGCAAGGAGTAC	0.672													A	37442646	A	A	37442646	3	1	223	1	0	0	0	0	1	0	0	0	2708	1087	38	1	235	1	CBR1	21	37442646	Missense_Mutation	SNP	G	TCGA-32-1979-01A-01D-1696-08		37442646	10687249	92	15715											
RIPK4	54101	broad.mit.edu	37	chr21	43161157	43161157	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcgcgctgagcccctgctcGtcgaacaggtcaatgacatc	11	14	1	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr21:43161157G>A	uc002yzn.1	-	8	2244	c.2196C>T	c.(2194-2196)GAC>GAT	p.D732D		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	732						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GCCCCTGCTCGTCGAACAGGT	0.692													A	43161157	A	A	43161157	2	1	223	1	0	0	0	0	0	0	0	1	13383	1136	40	1		1	RIPK4	21	43161157	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	5718511	43161157	4968738	93	15716											
C21orf58	54058	broad.mit.edu	37	chr21	47738114	47738114	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtgttgcctgcagggcgggCcttacctcctggagaccagc	15	13	0	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr21:47738114C>A	uc002zjf.2	-	3	1255	c.121G>T	c.(121-123)GCC>TCC	p.A41S	C21orf58_uc002ziz.2_5'UTR|C21orf58_uc002zja.2_5'UTR|C21orf58_uc011afw.1_5'UTR|C21orf58_uc002zjc.2_5'UTR|C21orf58_uc011afx.1_5'UTR|C21orf58_uc010gqj.1_RNA|C21orf58_uc002zjg.1_RNA	NM_058180	NP_478060	P58505	CU058_HUMAN	hypothetical protein LOC54058	41										pancreas(1)	1	Breast(49;0.112)			Colorectal(79;0.239)		GCAGGGCGGGCCTTACCTCCT	0.652													A	47738114	A	A	47738114	3	1	223	1	0	0	0	0	1	0	0	0	2129	739	26	5	875	5	C21orf58	21	47738114	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	4576957	47738114	391781	94	15717											
DIP2A	23181	broad.mit.edu	37	chr21	47954567	47954567	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catccctgctggcacagtgcCgggctctgacccaggcgtgc	13	16	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chr21:47954567C>T	uc002zjo.2	+	13	1792	c.1609C>T	c.(1609-1611)CGG>TGG	p.R537W	DIP2A_uc011afy.1_Missense_Mutation_p.R473W|DIP2A_uc011afz.1_Missense_Mutation_p.R533W|DIP2A_uc002zjl.2_Missense_Mutation_p.R537W|DIP2A_uc002zjm.2_Missense_Mutation_p.R537W|DIP2A_uc010gql.2_Missense_Mutation_p.R494W|DIP2A_uc002zjn.2_Missense_Mutation_p.R537W|DIP2A_uc002zjp.1_Missense_Mutation_p.R282W	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	537					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GGCACAGTGCCGGGCTCTGAC	0.562													T	47954567	T	T	47954567	3	4	223	1	0	0	0	0	1	0	0	0	4527	643	23	2	1659	2	DIP2A	21	47954567	Missense_Mutation	SNP	C	TCGA-32-1979-01A-01D-1696-08	216453	47954567	175328	95	15718											
ZMYM3	9203	broad.mit.edu	37	chrX	70469493	70469493	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaagaatcgctgcagagccGgtgtaccacgctgccattgc	12	13	0	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chrX:70469493G>T	uc004dzh.1	-	7	1375	c.1288C>A	c.(1288-1290)CGG>AGG	p.R430R	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.R430R|ZMYM3_uc004dzj.1_Silent_p.R430R|ZMYM3_uc011mpu.1_Silent_p.R161R|ZMYM3_uc004dzk.3_Silent_p.R430R|ZMYM3_uc004dzl.3_Silent_p.R430R|ZMYM3_uc004dzm.3_Silent_p.R430R	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	430	MYM-type 3.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CTGCAGAGCCGGTGTACCACG	0.587													T	70469493	T	T	70469493	2	4	223	1	0	0	0	0	0	0	0	1	17698	1115	39	5		5	ZMYM3	23	70469493	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08		70469493	84801067	96	15719											
COL4A6	1288	broad.mit.edu	37	chrX	107431199	107431199	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcattccttggattgtactgAgaattggttcccccttcttt	8	10	1	1			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chrX:107431199A>T	uc004enw.3	-	22	1752	c.1649T>A	c.(1648-1650)CTC>CAC	p.L550H	COL4A6_uc004env.3_Missense_Mutation_p.L549H|COL4A6_uc011msn.1_Missense_Mutation_p.L549H|COL4A6_uc010npk.2_Missense_Mutation_p.L549H	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	550	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						GATTGTACTGAGAATTGGTTC	0.512									Alport_syndrome_with_Diffuse_Leiomyomatosis				T	107431199	T	T	107431199	3	4	223	1	0	0	0	0	1	0	0	0	3695	304	11	5	3522	5	COL4A6	23	107431199	Missense_Mutation	SNP	A	TCGA-32-1979-01A-01D-1696-08	36961706	107431199	47839361	97	15720											
DCAF12L1	139170	broad.mit.edu	37	chrX	125685359	125685359	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	acccagaaatcattgtggttGagccagcctctgccacaggc	10	13	2	2			TCGA-32-1979-01A-01D-1696-08	TCGA-32-1979-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c81ebb9-20a6-40c1-9be2-17b99517e988	26bc13cd-9304-4181-b19a-9d1134ed6253	g.chrX:125685359G>A	uc004eul.2	-	1	1484	c.1233C>T	c.(1231-1233)CTC>CTT	p.L411L		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	411										skin(3)|ovary(1)	4						CATTGTGGTTGAGCCAGCCTC	0.552													A	125685359	A	A	125685359	2	1	223	1	0	0	0	0	0	0	0	1	4264	1277	45	3		3	DCAF12L1	23	125685359	Silent	SNP	G	TCGA-32-1979-01A-01D-1696-08	18254160	125685359	29585201	98	15721											
USH2A	7399	broad.mit.edu	37	chr1	215820917	215820917	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagccgtactgcccacctcgTtgtgtgccaccactctcagc	8	17	1	0			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr1:215820917T>C	uc001hku.1	-	67	15125	c.14738A>G	c.(14737-14739)AAC>AGC	p.N4913S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4913	Extracellular (Potential).|Fibronectin type-III 34.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCCCACCTCGTTGTGTGCCAC	0.478										HNSCC(13;0.011)			C	215820917	C	C	215820917	3	2	224	1	0	0	0	0	1	0	0	0	17033	1725	60	4	894	4	USH2A	1	215820917	Missense_Mutation	SNP	T	TCGA-32-1980-01A-01D-1696-08		215820917	33429704	1	15722											
TAF1A	9015	broad.mit.edu	37	chr1	222761835	222761835	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaaaatgcattcctgcaccaCtgagcacagatgtttccact	7	12	0	2			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr1:222761835C>G	uc009xdz.1	-	2	260	c.71G>C	c.(70-72)AGT>ACT	p.S24T	TAF1A_uc001hni.1_5'UTR|TAF1A_uc001hnj.2_Missense_Mutation_p.S24T|TAF1A_uc001hnk.2_5'UTR|TAF1A_uc010pur.1_Missense_Mutation_p.S24T	NM_139352	NP_647603	Q15573	TAF1A_HUMAN	TBP-associated factor 1A isoform 2	24					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding				0				GBM - Glioblastoma multiforme(131;0.0186)		TCCTGCACCACTGAGCACAGA	0.373													G	222761835	G	G	222761835	3	3	224	1	0	0	0	0	1	0	0	0	15516	565	20	5	1321	5	TAF1A	1	222761835	Missense_Mutation	SNP	C	TCGA-32-1980-01A-01D-1696-08	6940918	222761835	26488786	2	15723											
TTN	7273	broad.mit.edu	37	chr2	179640164	179640164	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gatgctggcagagtcctcagCagtcacatctcttatgacca	9	12	3	2			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr2:179640164C>G	uc010zfg.1	-	28	6651	c.6427G>C	c.(6427-6429)GCT>CCT	p.A2143P	TTN_uc010zfh.1_Missense_Mutation_p.A2097P|TTN_uc010zfi.1_Missense_Mutation_p.A2097P|TTN_uc010zfj.1_Missense_Mutation_p.A2097P|TTN_uc002unb.2_Missense_Mutation_p.A2143P|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2143							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGTCCTCAGCAGTCACATCT	0.443													G	179640164	G	G	179640164	3	3	224	1	0	0	0	0	1	0	0	0	16732	710	25	5	104901	5	TTN	2	179640164	Missense_Mutation	SNP	C	TCGA-32-1980-01A-01D-1696-08		179640164	63559209	3	15724											
BCL6	604	broad.mit.edu	37	chr3	187447774	187447774	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctgttgaggaactcttcaCgaggaggcttgatggcagaa	15	7	2	3			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr3:187447774C>T	uc003frp.3	-	5	876	c.419G>A	c.(418-420)CGT>CAT	p.R140H	BCL6_uc011bsf.1_Missense_Mutation_p.R140H|BCL6_uc010hza.2_Missense_Mutation_p.R38H|BCL6_uc003frq.1_Missense_Mutation_p.R140H	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	140					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GAACTCTTCACGAGGAGGCTT	0.522			T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								T	187447774	T	T	187447774	3	4	224	1	0	0	0	0	1	0	0	0	1376	536	19	1	1725	1	BCL6	3	187447774	Missense_Mutation	SNP	C	TCGA-32-1980-01A-01D-1696-08		187447774	10574656	4	15725											
REST	5978	broad.mit.edu	37	chr4	57777086	57777086	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaagaaggagaaggacttgaAgagtctgctgatataaaagg	14	3	1	5			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr4:57777086A>G	uc003hch.2	+	2	629	c.282A>G	c.(280-282)GAA>GAG	p.E94E	REST_uc003hci.2_Silent_p.E94E|REST_uc003hcj.1_Silent_p.E94E|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	94	Interaction with SIN3A.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					AAGGACTTGAAGAGTCTGCTG	0.458													G	57777086	G	G	57777086	2	3	224	1	0	0	0	0	0	0	0	1	13234	69	3	4		4	REST	4	57777086	Silent	SNP	A	TCGA-32-1980-01A-01D-1696-08		57777086	133377190	5	15726											
SPARCL1	8404	broad.mit.edu	37	chr4	88415064	88415064	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctaggccagttttaccctcTtgactctgccattcagtttc	6	13	4	1			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr4:88415064T>C	uc010ikm.2	-	5	1460	c.888A>G	c.(886-888)CAA>CAG	p.Q296Q	SPARCL1_uc011cdc.1_Silent_p.Q171Q|SPARCL1_uc003hqs.3_Silent_p.Q296Q|SPARCL1_uc011cdd.1_Silent_p.Q171Q|SPARCL1_uc003hqt.2_Silent_p.Q296Q	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	296					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TTTTACCCTCTTGACTCTGCC	0.418													C	88415064	C	C	88415064	2	2	224	1	0	0	0	0	0	0	0	1	14995	1606	56	4		4	SPARCL1	4	88415064	Silent	SNP	T	TCGA-32-1980-01A-01D-1696-08	30637978	88415064	102739212	6	15727											
FAT4	79633	broad.mit.edu	37	chr4	126337603	126337603	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtatgtactgttctacagGtggtggcaagagatgatgat	14	4	1	3			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr4:126337603G>A	uc003ifj.3	+	6	6844	c.6844G>A	c.(6844-6846)GTG>ATG	p.V2282M	FAT4_uc011cgp.1_Missense_Mutation_p.V580M	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2282	Extracellular (Potential).|Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGTTCTACAGGTGGTGGCAAG	0.368													A	126337603	A	A	126337603	3	1	224	1	0	0	0	0	1	0	0	0	5692	1275	44	3	6866	3	FAT4	4	126337603	Missense_Mutation	SNP	G	TCGA-32-1980-01A-01D-1696-08	37922539	126337603	64816673	7	15728											
NHLRC1	378884	broad.mit.edu	37	chr6	18122155	18122155	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgcatcagttaccacaatcCcattctgaggggtggtctcc	9	14	3	1			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr6:18122155C>T	uc003ncl.1	-	1	697	c.683G>A	c.(682-684)GGG>GAG	p.G228E		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	228	NHL 3.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			TACCACAATCCCATTCTGAGG	0.532													T	18122155	T	T	18122155	3	4	224	1	0	0	0	0	1	0	0	0	10405	623	22	3	508	3	NHLRC1	6	18122155	Missense_Mutation	SNP	C	TCGA-32-1980-01A-01D-1696-08		18122155	152992912	8	15729											
OR9A4	130075	broad.mit.edu	37	chr7	141619469	141619469	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacgtgaaacccaagcaaaCgcaggcagctgattacaatt	8	11	0	2			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr7:141619469C>T	uc003vwu.1	+	1	794	c.794C>T	c.(793-795)ACG>ATG	p.T265M		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					CCCAAGCAAACGCAGGCAGCT	0.478													T	141619469	T	T	141619469	3	4	224	1	0	0	0	0	1	0	0	0	11249	536	19	1	796	1	OR9A4	7	141619469	Missense_Mutation	SNP	C	TCGA-32-1980-01A-01D-1696-08		141619469	17519194	9	15730											
ZNF782	158431	broad.mit.edu	37	chr9	99581330	99581330	+	Silent	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tgagttctctgatgcactggGagggttgaattacggttgaa	14	5	1	4			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr9:99581330G>C	uc004awp.1	-	6	1256	c.975C>G	c.(973-975)CTC>CTG	p.L325L	ZNF782_uc011lup.1_Silent_p.L193L	NM_001001662	NP_001001662	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	325	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				GATGCACTGGGAGGGTTGAAT	0.398													C	99581330	C	C	99581330	2	2	224	1	0	0	0	0	0	0	0	1	18152	1161	41	5		5	ZNF782	9	99581330	Silent	SNP	G	TCGA-32-1980-01A-01D-1696-08		99581330	41632101	10	15731											
LGALS12	85329	broad.mit.edu	37	chr11	63273794	63273794	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctccagacagcattaaaaCgctgcaggtcgcaggtgaga	12	10	0	2			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr11:63273794C>T	uc001nxa.2	+	1	271	c.-70C>T	c.(-72--68)AACGC>AATGC		LGALS12_uc001nxb.2_Translation_Start_Site|LGALS12_uc001nxc.2_Translation_Start_Site|LGALS12_uc001nxd.2_5'Flank|LGALS12_uc001nxe.2_5'Flank|LGALS12_uc009yot.2_5'Flank	NM_033101	NP_149092	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12 isoform						apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			ovary(2)	2						AGCATTAAAACGCTGCAGGTC	0.637													T	63273794	T	T	63273794	1	4	224	1	0	0	0	0	0	0	0	0	8739	551	19	1		1	LGALS12	11	63273794	Translation_Start_Site	SNP	C	TCGA-32-1980-01A-01D-1696-08		63273794	71732722	11	15732											
ARCN1	372	broad.mit.edu	37	chr11	118461139	118461139	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tatggagttgcatggcatgaTcatgcttaggatctcagatg	12	6	2	2			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr11:118461139T>A	uc001ptq.2	+	6	1063	c.902T>A	c.(901-903)ATC>AAC	p.I301N	ARCN1_uc009zah.2_Intron|ARCN1_uc010ryg.1_Missense_Mutation_p.I213N|ARCN1_uc009zag.2_Missense_Mutation_p.I342N	NM_001655	NP_001646	P48444	COPD_HUMAN	archain isoform 1	301	MHD.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		CATGGCATGATCATGCTTAGG	0.393													A	118461139	A	A	118461139	3	1	224	1	0	0	0	0	1	0	0	0	842	1435	50	5	924	5	ARCN1	11	118461139	Missense_Mutation	SNP	T	TCGA-32-1980-01A-01D-1696-08	55187345	118461139	16545377	12	15733											
KIF21A	55605	broad.mit.edu	37	chr12	39716483	39716483	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aacttacatgctgcctatctTagaaggtaagccaggtgggg	12	8	1	1	rs147620197		TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr12:39716483T>C	uc001rly.2	-	27	3804	c.3658A>G	c.(3658-3660)AAG>GAG	p.K1220E	KIF21A_uc001rlv.2_Missense_Mutation_p.K225E|KIF21A_uc001rlw.2_Missense_Mutation_p.K537E|KIF21A_uc001rlx.2_Missense_Mutation_p.K1207E|KIF21A_uc001rlz.2_Missense_Mutation_p.K1184E|KIF21A_uc010skl.1_Missense_Mutation_p.K1200E	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1220					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CTGCCTATCTTAGAAGGTAAG	0.398													C	39716483	C	C	39716483	3	2	224	1	0	0	0	0	1	0	0	0	8288	1763	61	4	1414	4	KIF21A	12	39716483	Missense_Mutation	SNP	T	TCGA-32-1980-01A-01D-1696-08		39716483	94135412	13	15734											
F10	2159	broad.mit.edu	37	chr13	113803697	113803697	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctggggagagggctgtgccCgtaaggggaagtacgggatc	20	7	0	1			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr13:113803697C>T	uc001vsx.2	+	8	1390	c.1333C>T	c.(1333-1335)CGT>TGT	p.R445C	F10_uc001vsy.2_3'UTR|F10_uc001vsz.2_3'UTR	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	445	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGCTGTGCCCGTAAGGGGAA	0.627													T	113803697	T	T	113803697	3	4	224	1	0	0	0	0	1	0	0	0	5336	652	23	2	1363	2	F10	13	113803697	Missense_Mutation	SNP	C	TCGA-32-1980-01A-01D-1696-08		113803697	1366181	14	15735											
CFL2	1073	broad.mit.edu	37	chr14	35182132	35182132	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccaatttctctccaagtgtcGaacggtccttaatatcatcc	5	13	2	0			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr14:35182132G>A	uc001wsg.3	-	4	581	c.440C>T	c.(439-441)TCG>TTG	p.S147L	CFL2_uc010tpn.1_Missense_Mutation_p.S130L|CFL2_uc001wsh.3_Missense_Mutation_p.S147L|CFL2_uc001wsi.3_RNA|CFL2_uc001wsj.3_RNA	NM_021914	NP_068733	Q9Y281	COF2_HUMAN	cofilin 2	147	ADF-H.					cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(2)	2	Breast(36;0.0361)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;6.07e-06)|Lung(238;2.23e-05)|Epithelial(34;0.0387)|all cancers(34;0.0814)	GBM - Glioblastoma multiforme(112;0.0424)		TCCAAGTGTCGAACGGTCCTT	0.338													A	35182132	A	A	35182132	3	1	224	1	0	0	0	0	1	0	0	0	3291	1059	37	2	64	2	CFL2	14	35182132	Missense_Mutation	SNP	G	TCGA-32-1980-01A-01D-1696-08		35182132	72167408	15	15736											
NF1	4763	broad.mit.edu	37	chr17	29663349	29663349	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttattttccttcttcaactAgattacagatctgcttgatg	6	8	3	3			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr17:29663349A>G	uc002hgg.2	+	41	6340	c.6007_splice	c.e41-2	p.I2003_splice	NF1_uc002hgh.2_Splice_Site_p.I1982_splice|NF1_uc010cso.2_Splice_Site_p.I191_splice|NF1_uc010wbt.1_5'Flank|NF1_uc010wbu.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTCTTCAACTAGATTACAGAT	0.323			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			G	29663349	G	G	29663349	5	3	224	1	0	0	0	0	0	0	1	0	10356	434	15	4	6228	4	NF1	17	29663349	Splice_Site	SNP	A	TCGA-32-1980-01A-01D-1696-08		29663349	51531861	16	15737											
MUC16	94025	broad.mit.edu	37	chr19	9075072	9075072	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtatgtaaatctctgagtcGtagccagtggagtccctgtc	11	9	1	1			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr19:9075072G>A	uc002mkp.2	-	3	12578	c.12374C>T	c.(12373-12375)ACG>ATG	p.T4125M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4127	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTCTGAGTCGTAGCCAGTGG	0.502													A	9075072	A	A	9075072	3	1	224	1	0	0	0	0	1	0	0	0	9973	1145	40	1	31477	1	MUC16	19	9075072	Missense_Mutation	SNP	G	TCGA-32-1980-01A-01D-1696-08		9075072	50053911	17	15738											
NDUFA13	51079	broad.mit.edu	37	chr19	19645858	19645858	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accaggcgttcccgttgcccGctctctcccggaagcagagg	12	16	1	1			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr19:19645858G>A	uc010xqy.1	+	5	839	c.580G>A	c.(580-582)GCT>ACT	p.A194T	NDUFA13_uc010xqx.1_3'UTR|YJEFN3_uc002nmt.1_Missense_Mutation_p.A112T|YJEFN3_uc010ecf.1_Missense_Mutation_p.A62T|YJEFN3_uc002nmu.1_RNA	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	CCCGTTGCCCGCTCTCTCCCG	0.498													A	19645858	A	A	19645858	3	1	224	1	0	0	0	0	1	0	0	0	10263	1087	38	1		1	NDUFA13	19	19645858	Missense_Mutation	SNP	G	TCGA-32-1980-01A-01D-1696-08	10570786	19645858	39483125	18	15739											
NLRP4	147945	broad.mit.edu	37	chr19	56379119	56379119	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattgattgtgaagtccttgCtggccttctaaccaacaaca	7	11	1	2			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr19:56379119C>T	uc002qmd.3	+	6	2653	c.2231C>T	c.(2230-2232)GCT>GTT	p.A744V	NLRP4_uc002qmf.2_Missense_Mutation_p.A669V|NLRP4_uc010etf.2_Intron	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	744	LRR 3.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GAAGTCCTTGCTGGCCTTCTA	0.483													T	56379119	T	T	56379119	3	4	224	1	0	0	0	0	1	0	0	0	10479	797	28	3	2249	3	NLRP4	19	56379119	Missense_Mutation	SNP	C	TCGA-32-1980-01A-01D-1696-08	36733261	56379119	2749864	19	15740											
PCNT	5116	broad.mit.edu	37	chr21	47845820	47845820	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gccttgcacccccaagcggcGagccacacccaccccggaag	10	20	0	0			TCGA-32-1980-01A-01D-1696-08	TCGA-32-1980-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	9b267205-1994-46ff-8d0f-56625dae7c1b	2e957afb-4381-47c2-adc8-a49a224c5edb	g.chr21:47845820G>A	uc002zji.3	+	33	7362	c.7255G>A	c.(7255-7257)GAG>AAG	p.E2419K	PCNT_uc002zjj.2_Missense_Mutation_p.E2301K	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2419					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CCCAAGCGGCGAGCCACACCC	0.577													A	47845820	A	A	47845820	3	1	224	1	0	0	0	0	1	0	0	0	11590	1059	37	2	7385	2	PCNT	21	47845820	Missense_Mutation	SNP	G	TCGA-32-1980-01A-01D-1696-08		47845820	284075	20	15741											
MACF1	23499	broad.mit.edu	37	chr1	39750772	39750772	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggtgtggattgaatttggCcgaattaaactgcctcaagg	12	7	1	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr1:39750772C>T	uc010ois.1	+	13	1369	c.1164C>T	c.(1162-1164)GGC>GGT	p.G388G	MACF1_uc001cda.1_Silent_p.G296G	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	388	LRR 3.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTGAATTTGGCCGAATTAAAC	0.433													T	39750772	T	T	39750772	2	4	225	1	0	0	0	0	0	0	0	1	9144	726	26	3		3	MACF1	1	39750772	Silent	SNP	C	TCGA-32-1982-01A-01D-1494-08		39750772	209499849	1	15742											
ANKRD34A	284615	broad.mit.edu	37	chr1	145473561	145473561	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatcgcagaccgattagggcGcacggcgctcatgcacgctt	12	13	1	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr1:145473561G>A	uc001enq.1	+	4	1526	c.233G>A	c.(232-234)CGC>CAC	p.R78H	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	78	ANK 3.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGATTAGGGCGCACGGCGCTC	0.706													A	145473561	A	A	145473561	3	1	225	1	0	0	0	0	1	0	0	0	662	1087	38	1	235	1	ANKRD34A	1	145473561	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	105722789	145473561	103777060	2	15743											
MTMR11	10903	broad.mit.edu	37	chr1	149901667	149901667	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agccaggctttcagaggagaTagcaggtcgagggagccaac	15	9	1	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr1:149901667T>C	uc001etl.3	-	16	2040	c.1789A>G	c.(1789-1791)ATC>GTC	p.I597V	SF3B4_uc001etj.1_5'Flank|SF3B4_uc001etk.1_5'Flank|SF3B4_uc009wll.1_5'Flank|MTMR11_uc001etm.1_Missense_Mutation_p.I525V	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	597	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			TCAGAGGAGATAGCAGGTCGA	0.597													C	149901667	C	C	149901667	3	2	225	1	0	0	0	0	1	0	0	0	9940	1406	49	4	387	4	MTMR11	1	149901667	Missense_Mutation	SNP	T	TCGA-32-1982-01A-01D-1494-08	4428106	149901667	99348954	3	15744											
LYST	1130	broad.mit.edu	37	chr1	235993676	235993676	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcaaagccggttgacatcGgtcagaaattcacgtgccag	11	10	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr1:235993676G>A	uc001hxj.2	-	3	217	c.42C>T	c.(40-42)ACC>ACT	p.T14T	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Silent_p.T14T|LYST_uc001hxm.2_RNA|LYST_uc001hxn.1_Silent_p.T14T	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	14					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGTTGACATCGGTCAGAAATT	0.458									Chediak-Higashi_syndrome				A	235993676	A	A	235993676	2	1	225	1	0	0	0	0	0	0	0	1	9128	1103	39	2		2	LYST	1	235993676	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	86092009	235993676	13256945	4	15745											
OR2AK2	391191	broad.mit.edu	37	chr1	248128698	248128698	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgaaaacaggaaatcaaaGttttgggacagattttctac	8	6	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr1:248128698G>A	uc010pzd.1	+	1	65	c.65G>A	c.(64-66)AGT>AAT	p.S22N	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S22R(1)		ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GGAAATCAAAGTTTTGGGACA	0.279													A	248128698	A	A	248128698	3	1	225	1	0	0	0	0	1	0	0	0	10986	1029	36	3	67	3	OR2AK2	1	248128698	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	12135022	248128698	1121923	5	15746											
OR2T33	391195	broad.mit.edu	37	chr1	248436720	248436720	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gcacagctgccagctcatgaGagtgggatatcggagtgggt	16	8	1	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr1:248436720G>A	uc010pzi.1	-	1	397	c.397C>T	c.(397-399)CTC>TTC	p.L133F		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	133	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CAGCTCATGAGAGTGGGATAT	0.592													A	248436720	A	A	248436720	3	1	225	1	0	0	0	0	1	0	0	0	11024	942	33	3	568	3	OR2T33	1	248436720	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	308022	248436720	813901	6	15747											
TPO	7173	broad.mit.edu	37	chr2	1544411	1544411	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcccatctcggagacaggCggaggaactcccgagctgag	14	13	1	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr2:1544411C>T	uc002qww.2	+	16	2755	c.2664C>T	c.(2662-2664)GGC>GGT	p.G888G	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Silent_p.G831G|TPO_uc002qwr.2_Silent_p.G888G|TPO_uc002qwx.2_Silent_p.G831G|TPO_uc010yio.1_Silent_p.G715G|TPO_uc010yip.1_Silent_p.G844G|TPO_uc002qwy.1_Silent_p.G184G|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	888	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CGGAGACAGGCGGAGGAACTC	0.642													T	1544411	T	T	1544411	2	4	225	1	0	0	0	0	0	0	0	1	16407	755	27	1		1	TPO	2	1544411	Silent	SNP	C	TCGA-32-1982-01A-01D-1494-08		1544411	241654962	7	15748											
ALLC	55821	broad.mit.edu	37	chr2	3730599	3730599	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaggaaaccctgcttccgGccacaactattttcttgtca	7	14	2	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr2:3730599G>A	uc010ewt.2	+	7	607	c.446G>A	c.(445-447)GGC>GAC	p.G149D		NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	168							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		CCTGCTTCCGGCCACAACTAT	0.438										HNSCC(21;0.051)			A	3730599	A	A	3730599	3	1	225	1	0	0	0	0	1	0	0	0	534	1203	42	3	468	3	ALLC	2	3730599	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	2186188	3730599	239468774	8	15749											
APOB	338	broad.mit.edu	37	chr2	21256280	21256280	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agctctctggatattttgctCagagatggttagttttttca	9	6	3	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr2:21256280C>A	uc002red.2	-	9	1143	c.1015G>T	c.(1015-1017)GAG>TAG	p.E339*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	339	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATATTTTGCTCAGAGATGGTT	0.468													A	21256280	A	A	21256280	4	1	225	1	0	0	0	0	0	1	0	0	785	835	29	5	12760	5	APOB	2	21256280	Nonsense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	17525681	21256280	221943093	9	15750											
C2orf71	388939	broad.mit.edu	37	chr2	29294478	29294478	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccagggggctcacagaggCcctcagctttggggaagccc	15	13	2	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr2:29294478C>T	uc002rmt.1	-	1	2650	c.2650G>A	c.(2650-2652)GCC>ACC	p.A884T		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	884					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						CTCACAGAGGCCCTCAGCTTT	0.657													T	29294478	T	T	29294478	3	4	225	1	0	0	0	0	1	0	0	0	2191	739	26	3	1224	3	C2orf71	2	29294478	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	8038198	29294478	213904895	10	15751											
AMMECR1L	83607	broad.mit.edu	37	chr2	128631538	128631538	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttggcagttccattaggccGgggaagagggctcagcgctc	16	10	1	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr2:128631538G>A	uc002tpl.2	-	3	522	c.271C>T	c.(271-273)CGG>TGG	p.R91W	AMMECR1L_uc002tpm.2_Missense_Mutation_p.R91W	NM_031445	NP_113633	Q6DCA0	AMERL_HUMAN	AMME chromosomal region gene 1-like	91										central_nervous_system(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.07)		CCATTAGGCCGGGGAAGAGGG	0.547													A	128631538	A	A	128631538	3	1	225	1	0	0	0	0	1	0	0	0	579	1115	39	2	685	2	AMMECR1L	2	128631538	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	99337060	128631538	114567835	11	15752											
TTN	7273	broad.mit.edu	37	chr2	179457195	179457195	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caccatcttcatgggcagcaTtacgaatttcaagcttgcta	7	11	3	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr2:179457195T>G	uc010zfg.1	-	250	52057	c.51833A>C	c.(51832-51834)AAT>ACT	p.N17278T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N10973T|TTN_uc010zfi.1_Missense_Mutation_p.N10906T|TTN_uc010zfj.1_Missense_Mutation_p.N10781T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18205							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGGGCAGCATTACGAATTTC	0.378													G	179457195	G	G	179457195	3	3	225	1	0	0	0	0	1	0	0	0	16732	1493	52	5	48690	5	TTN	2	179457195	Missense_Mutation	SNP	T	TCGA-32-1982-01A-01D-1494-08	50825657	179457195	63742178	12	15753											
TTN	7273	broad.mit.edu	37	chr2	179476881	179476881	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccagggcgtagggtggtcCaggagtggctgaaaataaaa	16	6	0	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr2:179476881C>T	uc010zfg.1	-	216	42777	c.42553G>A	c.(42553-42555)GGA>AGA	p.G14185R	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G7880R|TTN_uc010zfi.1_Missense_Mutation_p.G7813R|TTN_uc010zfj.1_Missense_Mutation_p.G7688R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15112							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGGGTGGTCCAGGAGTGGCT	0.428													T	179476881	T	T	179476881	3	4	225	1	0	0	0	0	1	0	0	0	16732	603	21	3	57820	3	TTN	2	179476881	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	19686	179476881	63722492	13	15754											
DNAH7	56171	broad.mit.edu	37	chr2	196681639	196681639	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttctaatatattgccttcCgaagatgaaagaacttctaa	5	8	3	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr2:196681639C>T	uc002utj.3	-	51	9575	c.9474G>A	c.(9472-9474)TCG>TCA	p.S3158S		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3158	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TATTGCCTTCCGAAGATGAAA	0.323													T	196681639	T	T	196681639	2	4	225	1	0	0	0	0	0	0	0	1	4606	639	23	2		2	DNAH7	2	196681639	Silent	SNP	C	TCGA-32-1982-01A-01D-1494-08	17204758	196681639	46517734	14	15755											
CHDH	55349	broad.mit.edu	37	chr3	53856599	53856599	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accctgctcacaagcgtctcGgcctcggccttgaggttggt	12	14	2	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr3:53856599G>A	uc003dgz.2	-	4	1214	c.774C>T	c.(772-774)GCC>GCT	p.A258A		NM_018397	NP_060867	Q8NE62	CHDH_HUMAN	choline dehydrogenase precursor	258					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			ovary(1)|central_nervous_system(1)	2		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	CAAGCGTCTCGGCCTCGGCCT	0.632													A	53856599	A	A	53856599	2	1	225	1	0	0	0	0	0	0	0	1	3333	1103	39	2		2	CHDH	3	53856599	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08		53856599	144165831	15	15756											
SULT1B1	27284	broad.mit.edu	37	chr4	70615520	70615520	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atccggggtgatggattcttCtccaattgttctatacctga	9	9	3	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr4:70615520C>G	uc003hen.2	-	4	592	c.294G>C	c.(292-294)GAG>GAC	p.E98D		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	98					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						ATGGATTCTTCTCCAATTGTT	0.383													G	70615520	G	G	70615520	3	3	225	1	0	0	0	0	1	0	0	0	15373	912	32	5	616	5	SULT1B1	4	70615520	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08		70615520	120538756	16	15757											
PRKG2	5593	broad.mit.edu	37	chr4	82074799	82074799	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agttttaattaatagttaccTttccttttgccaaaatgaaa	4	6	0	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr4:82074799T>C	uc003hmh.2	-	6	1003	c.989A>G	c.(988-990)AAG>AGG	p.K330R	PRKG2_uc011ccf.1_5'UTR|PRKG2_uc011ccg.1_5'UTR|PRKG2_uc011cch.1_Missense_Mutation_p.K330R	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	330	cGMP 2.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						AATAGTTACCTTTCCTTTTGC	0.333													C	82074799	C	C	82074799	3	2	225	1	0	0	0	0	1	0	0	0	12523	1623	56	4	1351	4	PRKG2	4	82074799	Missense_Mutation	SNP	T	TCGA-32-1982-01A-01D-1494-08	11459279	82074799	109079477	17	15758											
MMRN1	22915	broad.mit.edu	37	chr4	90874400	90874400	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatagacaagcttgcatttgAgtctgaaaatattaacagtg	8	5	1	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr4:90874400A>G	uc003hst.2	+	8	3589	c.3518A>G	c.(3517-3519)GAG>GGG	p.E1173G	MMRN1_uc010iku.2_Missense_Mutation_p.E476G|MMRN1_uc011cds.1_Missense_Mutation_p.E915G	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1173	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CTTGCATTTGAGTCTGAAAAT	0.368													G	90874400	G	G	90874400	3	3	225	1	0	0	0	0	1	0	0	0	9670	304	11	4	3548	4	MMRN1	4	90874400	Missense_Mutation	SNP	A	TCGA-32-1982-01A-01D-1494-08	8799601	90874400	100279876	18	15759											
ZFP42	132625	broad.mit.edu	37	chr4	188924074	188924074	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcaagccaagacctgcaggCggaaatagaacctgtcagcg	12	11	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr4:188924074C>T	uc003izg.1	+	3	358	c.113C>T	c.(112-114)GCG>GTG	p.A38V	ZFP42_uc003izh.1_Missense_Mutation_p.A38V|ZFP42_uc003izi.1_Missense_Mutation_p.A38V	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	38					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GACCTGCAGGCGGAAATAGAA	0.572													T	188924074	T	T	188924074	3	4	225	1	0	0	0	0	1	0	0	0	17647	768	27	1	115	1	ZFP42	4	188924074	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	98049674	188924074	2230202	19	15760											
ZFP42	132625	broad.mit.edu	37	chr4	188924640	188924640	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggaatgtgggaaagcgttcGttgagagctcaaaactaaag	13	6	1	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr4:188924640G>A	uc003izg.1	+	3	924	c.679G>A	c.(679-681)GTT>ATT	p.V227I	ZFP42_uc003izh.1_Missense_Mutation_p.V227I|ZFP42_uc003izi.1_Missense_Mutation_p.V227I	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	227	C2H2-type 2.				female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GAAAGCGTTCGTTGAGAGCTC	0.502													A	188924640	A	A	188924640	3	1	225	1	0	0	0	0	1	0	0	0	17647	1145	40	1	681	1	ZFP42	4	188924640	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	566	188924640	2229636	20	15761											
ANKRA2	57763	broad.mit.edu	37	chr5	72857050	72857050	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gtgagaaatgctttgttgtaGagggggtgtagacatgcctt	15	4	0	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr5:72857050G>A	uc003kcu.1	-	3	999	c.353C>T	c.(352-354)TCT>TTT	p.S118F	ANKRA2_uc003kcv.2_Missense_Mutation_p.S118F	NM_023039	NP_075526	Q9H9E1	ANRA2_HUMAN	ankyrin repeat, family A (RFXANK-like), 2	118						cytoskeleton|cytosol|membrane	low-density lipoprotein particle binding				0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)		OV - Ovarian serous cystadenocarcinoma(47;3.71e-54)		CTTTGTTGTAGAGGGGGTGTA	0.388													A	72857050	A	A	72857050	3	1	225	1	0	0	0	0	1	0	0	0	636	942	33	3	616	3	ANKRA2	5	72857050	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08		72857050	108058210	21	15762											
PCDHA1	56147	broad.mit.edu	37	chr5	140167547	140167547	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgcaggtgttcgtgctggacGagaacgacaacgcgccggcg	16	11	0	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr5:140167547G>A	uc003lhb.2	+	1	1672	c.1672G>A	c.(1672-1674)GAG>AAG	p.E558K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.E558K	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	558	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCTGGACGAGAACGACAA	0.672													A	140167547	A	A	140167547	3	1	225	1	0	0	0	0	1	0	0	0	11519	1059	37	2	1674	2	PCDHA1	5	140167547	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	67310497	140167547	40747713	22	15763											
PCDHA8	56140	broad.mit.edu	37	chr5	140221381	140221381	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttccgctagagggcgcgtccGatgcagatgttggagctaac	14	10	0	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr5:140221381G>A	uc003lhs.2	+	1	475	c.475G>A	c.(475-477)GAT>AAT	p.D159N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.D159N	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	159	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGCGTCCGATGCAGATGT	0.458													A	140221381	A	A	140221381	3	1	225	1	0	0	0	0	1	0	0	0	11530	1058	37	2	477	2	PCDHA8	5	140221381	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	53834	140221381	40693879	23	15764											
PCDHGB4	8641	broad.mit.edu	37	chr5	140769126	140769126	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accgcaacgacaatgcgccaCgggtgctgtaccccgcgctg	12	16	0	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr5:140769126C>T	uc003lkc.1	+	1	1675	c.1675C>T	c.(1675-1677)CGG>TGG	p.R559W	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.R559W	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	559	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATGCGCCACGGGTGCTGTA	0.662													T	140769126	T	T	140769126	3	4	225	1	0	0	0	0	1	0	0	0	11565	527	19	1	1677	1	PCDHGB4	5	140769126	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	547745	140769126	40146134	24	15765											
SLC36A3	285641	broad.mit.edu	37	chr5	150672978	150672978	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcgggcaggtttcaaggccGtacatcgtggcctctccata	11	12	2	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr5:150672978G>A	uc003ltw.2	-	4	770	c.351C>T	c.(349-351)TAC>TAT	p.Y117Y	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Silent_p.Y61Y|SLC36A3_uc003ltx.2_Silent_p.Y117Y	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	117	Cytoplasmic (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTCAAGGCCGTACATCGTGG	0.428													A	150672978	A	A	150672978	2	1	225	1	0	0	0	0	0	0	0	1	14595	1140	40	1		1	SLC36A3	5	150672978	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	9903852	150672978	30242282	25	15766											
ZNF193	7746	broad.mit.edu	37	chr6	28200919	28200919	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgacactgcaacctcattcGccatcagaagatccacacag	6	15	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr6:28200919G>A	uc003nkq.1	+	4	1263	c.1148G>A	c.(1147-1149)CGC>CAC	p.R383H	ZNF193_uc003nkr.1_Missense_Mutation_p.R383H|ZNF193_uc010jqz.1_Missense_Mutation_p.R434H	NM_006299	NP_006290	O15535	ZN193_HUMAN	zinc finger protein 193	383	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AACCTCATTCGCCATCAGAAG	0.502													A	28200919	A	A	28200919	3	1	225	1	0	0	0	0	1	0	0	0	17754	1087	38	1	1158	1	ZNF193	6	28200919	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08		28200919	142914148	26	15767											
EEF1A1	1915	broad.mit.edu	37	chr6	74228304	74228304	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gggtttgagaacaccagtctCcactcggccaacaggaacag	11	12	1	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr6:74228304C>T	uc003phi.2	-	5	839	c.802G>A	c.(802-804)GAG>AAG	p.E268K	EEF1A1_uc003phd.2_5'UTR|EEF1A1_uc003phe.2_Missense_Mutation_p.E258K|EEF1A1_uc003phf.2_Missense_Mutation_p.E268K|EEF1A1_uc003phg.2_Missense_Mutation_p.E268K|EEF1A1_uc003phh.2_Missense_Mutation_p.E114K|EEF1A1_uc003phj.2_Missense_Mutation_p.E268K|EEF1A1_uc003phk.2_Missense_Mutation_p.E268K|EEF1A1_uc003phl.2_Intron|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	268						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						ACACCAGTCTCCACTCGGCCA	0.418											OREG0003895	type=REGULATORY REGION|Gene=D16891|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	T	74228304	T	T	74228304	3	4	225	1	0	0	0	0	1	0	0	0	4923	864	30	3	598	3	EEF1A1	6	74228304	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	46027385	74228304	96886763	27	15768											
GPRC6A	222545	broad.mit.edu	37	chr6	117150029	117150031	+	In_Frame_Del	DEL	ACA	-	-													tctgggagagtcttctgaggAcaacattttttcatgaatag							TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr6:117150029_117150031delACA	uc003pxj.1	-	1	168_170	c.146_148delTGT	c.(145-150)TTGTCC>TCC	p.L49del	GPRC6A_uc003pxk.1_In_Frame_Del_p.L49del|GPRC6A_uc003pxl.1_In_Frame_Del_p.L49del	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	49	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TCTTCTGAGGACAACATTTTTTC	0.443													-	117150031	-	-	117150029	7	5	225	1	0	1	0	1	0	0	0	0	6728	275	10	0	2656	0	GPRC6A	6	117150029	In_Frame_Del	DEL	ACA	TCGA-32-1982-01A-01D-1494-08	42921725	117150029	53965038	28	15769											
HBS1L	10767	broad.mit.edu	37	chr6	135318720	135318720	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cagtctcaagaacatcggaaGaagcaatggcatcttcaatg	9	9	3	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr6:135318720G>C	uc003qez.2	-	6	821	c.614C>G	c.(613-615)TCT>TGT	p.S205C	HBS1L_uc003qey.2_Missense_Mutation_p.S41C|HBS1L_uc011ecy.1_Intron|HBS1L_uc011ecz.1_Missense_Mutation_p.S41C|HBS1L_uc011eda.1_Missense_Mutation_p.S163C	NM_006620	NP_006611	Q9Y450	HBS1L_HUMAN	Hsp70 subfamily B suppressor 1-like protein	205					signal transduction		GTP binding|GTPase activity|translation elongation factor activity			skin(2)	2	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		AACATCGGAAGAAGCAATGGC	0.443													C	135318720	C	C	135318720	3	2	225	1	0	0	0	0	1	0	0	0	6987	942	33	5	1492	5	HBS1L	6	135318720	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	18168691	135318720	35796347	29	15770											
BCLAF1	9774	broad.mit.edu	37	chr6	136582520	136582520	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catttaggactgctacctgaTtttttgaagttaaagcgccc	8	9	0	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr6:136582520T>C	uc003qgx.1	-	12	2893	c.2640A>G	c.(2638-2640)AAA>AAG	p.K880K	BCLAF1_uc011edb.1_Silent_p.K159K|BCLAF1_uc003qgw.1_Silent_p.K707K|BCLAF1_uc003qgy.1_Silent_p.K829K|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.K878K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	880					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGCTACCTGATTTTTTGAAGT	0.428													C	136582520	C	C	136582520	2	2	225	1	0	0	0	0	0	0	0	1	1383	1490	52	4		4	BCLAF1	6	136582520	Silent	SNP	T	TCGA-32-1982-01A-01D-1494-08	1263800	136582520	34532547	30	15771											
IFNGR1	3459	broad.mit.edu	37	chr6	137519737	137519737	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gagtgatacatattttgattCaggttttgtctctaaagtag	9	4	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr6:137519737C>G	uc003qho.2	-	7	1004	c.901G>C	c.(901-903)GAA>CAA	p.E301Q	IFNGR1_uc011edm.1_Missense_Mutation_p.E273Q	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	301	Cytoplasmic (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	TATTTTGATTCAGGTTTTGTC	0.393													G	137519737	G	G	137519737	3	3	225	1	0	0	0	0	1	0	0	0	7549	835	29	5	572	5	IFNGR1	6	137519737	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	937217	137519737	33595330	31	15772											
SYNE1	23345	broad.mit.edu	37	chr6	152831380	152831380	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccttcttagcatttccttGgatcttggtggtcaccttcc	8	12	3	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr6:152831380G>A	uc010kiw.2	-	8	1131	c.529C>T	c.(529-531)CAA>TAA	p.Q177*	SYNE1_uc003qot.3_Nonsense_Mutation_p.Q184*|SYNE1_uc003qou.3_Nonsense_Mutation_p.Q177*|SYNE1_uc010kjb.1_Nonsense_Mutation_p.Q177*|SYNE1_uc003qpa.1_Nonsense_Mutation_p.Q177*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	177	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCATTTCCTTGGATCTTGGTG	0.453										HNSCC(10;0.0054)			A	152831380	A	A	152831380	4	1	225	1	0	0	0	0	0	1	0	0	15442	1357	47	3	26493	3	SYNE1	6	152831380	Nonsense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	15311643	152831380	18283687	32	15773											
MAP3K4	4216	broad.mit.edu	37	chr6	161527602	161527602	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	agaagtcagtccgattgtttGaagaaaagaggtaccgagaa	12	5	1	5			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr6:161527602G>A	uc003qtn.2	+	20	4055	c.3913G>A	c.(3913-3915)GAA>AAA	p.E1305K	MAP3K4_uc010kkc.1_Missense_Mutation_p.E1301K|MAP3K4_uc003qto.2_Missense_Mutation_p.E1255K|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.E758K|MAP3K4_uc003qtp.2_Missense_Mutation_p.E241K|MAP3K4_uc003qtq.2_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1305					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CCGATTGTTTGAAGAAAAGAG	0.408													A	161527602	A	A	161527602	3	1	225	1	0	0	0	0	1	0	0	0	9252	1291	45	3	3991	3	MAP3K4	6	161527602	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	8696222	161527602	9587465	33	15774											
MAP3K4	4216	broad.mit.edu	37	chr6	161527656	161527656	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atatcattggtcaagtttgtGatacgcctaagtcctatgat	8	7	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr6:161527656G>A	uc003qtn.2	+	20	4109	c.3967G>A	c.(3967-3969)GAT>AAT	p.D1323N	MAP3K4_uc010kkc.1_Missense_Mutation_p.D1319N|MAP3K4_uc003qto.2_Missense_Mutation_p.D1273N|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.D776N|MAP3K4_uc003qtp.2_Missense_Mutation_p.D259N|MAP3K4_uc003qtq.2_Missense_Mutation_p.D12N	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1323					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TCAAGTTTGTGATACGCCTAA	0.398													A	161527656	A	A	161527656	3	1	225	1	0	0	0	0	1	0	0	0	9252	1290	45	3	4045	3	MAP3K4	6	161527656	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	54	161527656	9587411	34	15775											
ELMO1	9844	broad.mit.edu	37	chr7	37354483	37354483	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatatagaagtttgaactatCggcatgctggagtgcaaaat	11	5	0	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr7:37354483C>T	uc003tfk.1	-	4	470	c.163G>A	c.(163-165)GAT>AAT	p.D55N	ELMO1_uc010kxg.1_Missense_Mutation_p.D55N	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	55					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						TTTGAACTATCGGCATGCTGG	0.323													T	37354483	T	T	37354483	3	4	225	1	0	0	0	0	1	0	0	0	5065	884	31	2	2096	2	ELMO1	7	37354483	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08		37354483	121784180	35	15776											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	225	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	17878560	55233043	103905620	36	15777											
RABL5	64792	broad.mit.edu	37	chr7	100959711	100959711	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgtaaggacggctgttggaCaaagcaggaataccacatct	11	9	1	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr7:100959711C>A	uc003uyl.2	-	4	422	c.319G>T	c.(319-321)GTC>TTC	p.V107F	RABL5_uc011kkk.1_Missense_Mutation_p.V30F|RABL5_uc011kkl.1_Missense_Mutation_p.V30F|RABL5_uc003uym.2_Missense_Mutation_p.V77F|RABL5_uc010lhw.2_RNA|RABL5_uc011kkm.1_Missense_Mutation_p.V107F	NM_022777	NP_073614	Q9H7X7	RABL5_HUMAN	RAB, member RAS oncogene family-like 5 isoform	107							GTP binding				0	Lung NSC(181;0.215)					GGCTGTTGGACAAAGCAGGAA	0.502													A	100959711	A	A	100959711	3	1	225	1	0	0	0	0	1	0	0	0	12973	478	17	5	246	5	RABL5	7	100959711	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	45726668	100959711	58178952	37	15778											
SLC26A5	375611	broad.mit.edu	37	chr7	103050961	103050961	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggctctgtgagatatatGgccacaaatccaaacctaca	8	10	1	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr7:103050961G>A	uc003vbz.2	-	7	842	c.606C>T	c.(604-606)GCC>GCT	p.A202A	SLC26A5_uc003vbt.1_Silent_p.A202A|SLC26A5_uc003vbu.1_Silent_p.A202A|SLC26A5_uc003vbv.1_Silent_p.A202A|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Silent_p.A202A|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	202	Helical; Name=4; (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TGAGATATATGGCCACAAATC	0.408													A	103050961	A	A	103050961	2	1	225	1	0	0	0	0	0	0	0	1	14520	1335	47	3		3	SLC26A5	7	103050961	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	2091250	103050961	56087702	38	15779											
NUP205	23165	broad.mit.edu	37	chr7	135304420	135304420	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tcatattgaagaaactgttaGacttcattttgaagacaggt	8	5	2	5			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr7:135304420G>T	uc003vsw.2	+	29	4244	c.4213G>T	c.(4213-4215)GAC>TAC	p.D1405Y	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1405					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GAAACTGTTAGACTTCATTTT	0.303													T	135304420	T	T	135304420	3	4	225	1	0	0	0	0	1	0	0	0	10759	942	33	5	4327	5	NUP205	7	135304420	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	32253459	135304420	23834243	39	15780											
KEL	3792	broad.mit.edu	37	chr7	142650951	142650951	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtttttcaaatattccacGtcatggaccacgagggactg	9	9	2	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr7:142650951G>A	uc003wcb.2	-	9	1227	c.1017C>T	c.(1015-1017)GAC>GAT	p.D339D		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	339	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					AATATTCCACGTCATGGACCA	0.537													A	142650951	A	A	142650951	2	1	225	1	0	0	0	0	0	0	0	1	8142	1136	40	1		1	KEL	7	142650951	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	7346531	142650951	16487712	40	15781											
ARHGEF35	445328	broad.mit.edu	37	chr7	143884178	143884178	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggactctgtctgagtcccGggaatctgagtcacgagata	12	10	4	3	rs140097295		TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr7:143884178G>A	uc003wdz.1	-	2	1417	c.1299C>T	c.(1297-1299)CCC>CCT	p.P433P		NM_001003702	NP_001003702	A5YM69	ARG35_HUMAN	Rho guanine nucleotide exchange factor (GEF)	433											0						TCTGAGTCCCGGGAATCTGAG	0.567													A	143884178	A	A	143884178	2	1	225	1	0	0	0	0	0	0	0	1	905	1103	39	2		2	ARHGEF35	7	143884178	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	1233227	143884178	15254485	41	15782											
ADAM28	10863	broad.mit.edu	37	chr8	24181418	24181418	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	actgacaaggataagataaaGataaccccaaatgcaagctt	7	8	0	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr8:24181418G>A	uc003xdy.2	+	9	875	c.792G>A	c.(790-792)AAG>AAA	p.K264K	ADAM28_uc003xdx.2_Silent_p.K264K|ADAM28_uc011kzz.1_Silent_p.K31K|ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_5'Flank	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	264	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		ATAAGATAAAGATAACCCCAA	0.383													A	24181418	A	A	24181418	2	1	225	1	0	0	0	0	0	0	0	1	246	933	33	3		3	ADAM28	8	24181418	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08		24181418	122182604	42	15783											
JPH1	56704	broad.mit.edu	37	chr8	75171695	75171695	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctggcgagcggccagcgCggcctggtcggcggcatcgg	18	15	0	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr8:75171695C>T	uc003yae.2	-	3	1223	c.1183G>A	c.(1183-1185)GCG>ACG	p.A395T	JPH1_uc003yaf.2_Missense_Mutation_p.A395T|JPH1_uc003yag.1_Missense_Mutation_p.A259T	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	395	Ala-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GCGGCCAGCGCGGCCTGGTCG	0.597													T	75171695	T	T	75171695	3	4	225	1	0	0	0	0	1	0	0	0	7960	768	27	1	814	1	JPH1	8	75171695	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	50990277	75171695	71192327	43	15784											
ENPP2	5168	broad.mit.edu	37	chr8	120629796	120629796	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaagatgattaatggagggcGaacaaaccttaaacagtaac	10	6	0	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr8:120629796G>A	uc003yot.1	-	6	573	c.487C>T	c.(487-489)CGC>TGC	p.R163C	ENPP2_uc003yos.1_Missense_Mutation_p.R163C|ENPP2_uc010mdd.1_Missense_Mutation_p.R163C	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	163					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AATGGAGGGCGAACAAACCTT	0.368													A	120629796	A	A	120629796	3	1	225	1	0	0	0	0	1	0	0	0	5130	1058	37	2	2423	2	ENPP2	8	120629796	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	45458101	120629796	25734226	44	15785											
TSNARE1	203062	broad.mit.edu	37	chr8	143310871	143310871	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcggacagaggtggcgatgaTgatgatgatgacaagcaggg	17	5	0	6			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr8:143310871T>C	uc003ywk.2	-	13	1634	c.1516A>G	c.(1516-1518)ATC>GTC	p.I506V	TSNARE1_uc011lju.1_Missense_Mutation_p.I505V|TSNARE1_uc003ywj.2_Missense_Mutation_p.I507V	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	506	Poly-Ile.|Helical; (Potential).				vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GTGGCGATGATGATGATGATG	0.423													C	143310871	C	C	143310871	3	2	225	1	0	0	0	0	1	0	0	0	16627	1464	51	4	29	4	TSNARE1	8	143310871	Missense_Mutation	SNP	T	TCGA-32-1982-01A-01D-1494-08	22681075	143310871	3053151	45	15786											
EPB41L4B	54566	broad.mit.edu	37	chr9	112017853	112017853	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggatttgctgtttcctggCgtccgcagtcggaagaatgc	13	9	0	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr9:112017853C>T	uc004bdz.1	-	11	1402	c.1107G>A	c.(1105-1107)ACG>ACA	p.T369T	EPB41L4B_uc004bea.2_Silent_p.T369T	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	369	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						TGTTTCCTGGCGTCCGCAGTC	0.522													T	112017853	T	T	112017853	2	4	225	1	0	0	0	0	0	0	0	1	5156	755	27	1		1	EPB41L4B	9	112017853	Silent	SNP	C	TCGA-32-1982-01A-01D-1494-08		112017853	29195578	46	15787											
ARHGAP21	57584	broad.mit.edu	37	chr10	24874106	24874106	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatctagctgattttttcctGgaaagagtatcacattcgat	7	7	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr10:24874106G>A	uc001isb.2	-	26	5599	c.5112C>T	c.(5110-5112)TCC>TCT	p.S1704S	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1703	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						ATTTTTTCCTGGAAAGAGTAT	0.393													A	24874106	A	A	24874106	2	1	225	1	0	0	0	0	0	0	0	1	871	1335	47	3		3	ARHGAP21	10	24874106	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08		24874106	110660641	47	15788											
CUL2	8453	broad.mit.edu	37	chr10	35299303	35299303	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctatgtattgtttgtctatcAgaacttcaatacacttctta	4	8	4	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr10:35299303A>T	uc001ixv.2	-	21	2384	c.2174T>A	c.(2173-2175)CTG>CAG	p.L725Q	CUL2_uc009xma.2_Missense_Mutation_p.L594Q|CUL2_uc010qer.1_Missense_Mutation_p.L744Q|CUL2_uc001ixw.2_Missense_Mutation_p.L725Q	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	725					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						TTTGTCTATCAGAACTTCAAT	0.463													T	35299303	T	T	35299303	3	4	225	1	0	0	0	0	1	0	0	0	4055	188	7	5	67	5	CUL2	10	35299303	Missense_Mutation	SNP	A	TCGA-32-1982-01A-01D-1494-08	10425197	35299303	100235444	48	15789											
ZNF37A	7587	broad.mit.edu	37	chr10	38404217	38404217	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tttccaagccagagtcatctGggtgagttagtatgtgccag	12	8	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr10:38404217G>T	uc001izk.2	+	7	1056	c.237G>T	c.(235-237)CTG>CTT	p.L79L	ZNF37A_uc001izl.2_Silent_p.L79L|ZNF37A_uc001izm.2_Silent_p.L79L	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	79	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						AGAGTCATCTGGGTGAGTTAG	0.393													T	38404217	T	T	38404217	2	4	225	1	0	0	0	0	0	0	0	1	17869	1362	47	5		5	ZNF37A	10	38404217	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	3104914	38404217	97130530	49	15790											
LRRC18	474354	broad.mit.edu	37	chr10	50121795	50121795	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccccagtgtggtgggcaCgctgtccaggtggttcaagc	16	12	1	0	rs138127999		TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr10:50121795C>T	uc001jhd.2	-	1	486	c.406G>A	c.(406-408)GTG>ATG	p.V136M	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Missense_Mutation_p.V136M	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	136	LRR 5.					cytoplasm				ovary(1)|pancreas(1)	2						GTGGTGGGCACGCTGTCCAGG	0.602													T	50121795	T	T	50121795	3	4	225	1	0	0	0	0	1	0	0	0	8974	536	19	1	387	1	LRRC18	10	50121795	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	11717578	50121795	85412952	50	15791											
CHAT	1103	broad.mit.edu	37	chr10	50870733	50870733	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaaccacctgctggcactgCgggagctggcccgggccatg	14	15	0	0	rs116097791	by1000genomes	TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr10:50870733C>T	uc001jhz.2	+	14	2035	c.1882C>T	c.(1882-1884)CGG>TGG	p.R628W	CHAT_uc001jhv.1_Missense_Mutation_p.R510W|CHAT_uc001jhx.1_Missense_Mutation_p.R510W|CHAT_uc001jhy.1_Missense_Mutation_p.R510W|CHAT_uc001jia.2_Missense_Mutation_p.R510W|CHAT_uc010qgs.1_Missense_Mutation_p.R510W	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	628					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GCTGGCACTGCGGGAGCTGGC	0.572													T	50870733	T	T	50870733	3	4	225	1	0	0	0	0	1	0	0	0	3313	759	27	1	1980	1	CHAT	10	50870733	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	748938	50870733	84664014	51	15792											
PTEN	5728	broad.mit.edu	37	chr10	89692829	89692829	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagaacttatcaaaccctttTgtgaagatcttgaccaatgg	7	8	2	4			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr10:89692829T>C	uc001kfb.2	+	6	1344	c.313T>C	c.(313-315)TGT>CGT	p.C105R		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	105	Phosphatase tensin-type.		C -> F (in BZS; loss of phosphatase activity towards Ins(1,3,4,5)P4).|C -> Y (in BZS).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.C105F(6)|p.R55fs*1(4)|p.C105W(4)|p.C105S(3)|p.?(2)|p.Y27fs*1(2)|p.C105Y(2)|p.Y27_N212>Y(2)|p.C105fs*1(1)|p.C105fs*2(1)|p.C105G(1)|p.C105R(1)|p.F56fs*2(1)|p.P103fs*3(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CAAACCCTTTTGTGAAGATCT	0.378		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89692829	C	C	89692829	3	2	225	1	0	0	0	0	1	0	0	0	12738	1812	63	4	331	4	PTEN	10	89692829	Missense_Mutation	SNP	T	TCGA-32-1982-01A-01D-1494-08	38822096	89692829	45841918	52	15793											
OR5T3	390154	broad.mit.edu	37	chr11	56020589	56020589	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agaccatgacatcatagtgtCaatattttacacaattgtga	6	7	2	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr11:56020589C>T	uc010rjd.1	+	1	914	c.914C>T	c.(913-915)TCA>TTA	p.S305L		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	305	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					ATCATAGTGTCAATATTTTAC	0.368													T	56020589	T	T	56020589	3	4	225	1	0	0	0	0	1	0	0	0	11183	838	29	3	916	3	OR5T3	11	56020589	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08		56020589	78985927	53	15794											
ANO2	57101	broad.mit.edu	37	chr12	5724431	5724431	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaagctttgaggatcaggcGctcttcaaaagtctgttctg	11	8	5	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr12:5724431G>A	uc001qnm.2	-	18	1921	c.1849C>T	c.(1849-1851)CGC>TGC	p.R617C		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	622	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						AGGATCAGGCGCTCTTCAAAA	0.458													A	5724431	A	A	5724431	3	1	225	1	0	0	0	0	1	0	0	0	697	1087	38	1	1183	1	ANO2	12	5724431	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08		5724431	128127464	54	15795											
LRRK2	120892	broad.mit.edu	37	chr12	40689281	40689281	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagacagcatttcttctctGgcttctgagagagaatatat	8	8	4	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr12:40689281G>A	uc001rmg.3	+	23	3052	c.2931G>A	c.(2929-2931)CTG>CTA	p.L977L	LRRK2_uc001rmh.1_Silent_p.L599L|LRRK2_uc009zjw.2_5'UTR	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	977					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTTCTTCTCTGGCTTCTGAGA	0.343													A	40689281	A	A	40689281	2	1	225	1	0	0	0	0	0	0	0	1	9033	1335	47	3		3	LRRK2	12	40689281	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	34964850	40689281	93162614	55	15796											
LRRIQ1	84125	broad.mit.edu	37	chr12	85460676	85460676	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ataataaaattactcgaattGgtaagaacaatgaaatttta	5	3	0	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr12:85460676G>T	uc001tac.2	+	10	2806	c.2695G>T	c.(2695-2697)GGA>TGA	p.G899*	LRRIQ1_uc001tab.1_Nonsense_Mutation_p.G899*	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	899	LRR 4.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TACTCGAATTGGTAAGAACAA	0.274													T	85460676	T	T	85460676	4	4	225	1	0	0	0	0	0	1	0	0	9029	1362	47	5	2729	5	LRRIQ1	12	85460676	Nonsense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	44771395	85460676	48391219	56	15797											
CHD8	57680	broad.mit.edu	37	chr14	21860669	21860673	+	Frame_Shift_Del	DEL	TTTGA	-	-													ccaaatgctgagcttacatcTttgatttgaactgtaaactc							TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr14:21860669_21860673delTTTGA	uc001was.1	-	34	6021_6025	c.5927_5931delTCAAA	c.(5926-5931)ATCAAAfs	p.I1976fs	CHD8_uc001war.1_Frame_Shift_Del_p.I1872fs|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2255_2256					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AGCTTACATCTTTGATTTGAACTGT	0.468													-	21860673	-	-	21860669	7	5	225	1	0	1	0	1	0	0	0	0	3331	1606	56	0	997	0	CHD8	14	21860669	Frame_Shift_Del	DEL	TTTGA	TCGA-32-1982-01A-01D-1494-08		21860669	85488871	57	15798											
MYH6	4624	broad.mit.edu	37	chr14	23869930	23869930	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caactcacgtcgaagatctcGaagccagcgatgtccaggac	10	13	2	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr14:23869930G>A	uc001wjv.2	-	13	1465	c.1398C>T	c.(1396-1398)TTC>TTT	p.F466F	MYH6_uc010akp.1_Silent_p.F466F	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	466	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CGAAGATCTCGAAGCCAGCGA	0.438													A	23869930	A	A	23869930	2	1	225	1	0	0	0	0	0	0	0	1	10038	1049	37	2		2	MYH6	14	23869930	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	2009261	23869930	83479610	58	15799											
DICER1	23405	broad.mit.edu	37	chr14	95569923	95569923	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaatccatcctgcccttgagCacttgaatagtgtctgtcgt	9	11	1	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr14:95569923C>T	uc001ydw.2	-	22	3992	c.3810G>A	c.(3808-3810)GTG>GTA	p.V1270V	DICER1_uc010avh.1_Silent_p.V168V|DICER1_uc001ydv.2_Silent_p.V1260V|DICER1_uc001ydx.2_Silent_p.V1270V|DICER1_uc001ydy.1_Silent_p.V122V	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1270					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TGCCCTTGAGCACTTGAATAG	0.468			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				T	95569923	T	T	95569923	2	4	225	1	0	0	0	0	0	0	0	1	4521	697	25	3		3	DICER1	14	95569923	Silent	SNP	C	TCGA-32-1982-01A-01D-1494-08	71699993	95569923	11779617	59	15800											
RYR3	6263	broad.mit.edu	37	chr15	33895352	33895352	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaacatcttcctgggagtcGcggagggctcagcccagtac	12	13	2	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr15:33895352G>A	uc001zhi.2	+	18	2021	c.1951G>A	c.(1951-1953)GCG>ACG	p.A651T	RYR3_uc010bar.2_Missense_Mutation_p.A651T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	651	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTGGGAGTCGCGGAGGGCTC	0.527													A	33895352	A	A	33895352	3	1	225	1	0	0	0	0	1	0	0	0	13770	1087	38	1	2021	1	RYR3	15	33895352	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08		33895352	68636040	60	15801											
MFAP1	4236	broad.mit.edu	37	chr15	44105497	44105497	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	catgcgttttgcttcctgctCcagctccttctgtttcaatg	7	13	2	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr15:44105497C>G	uc001zth.1	-	5	860	c.676G>C	c.(676-678)GAG>CAG	p.E226Q		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	226						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		GCTTCCTGCTCCAGCTCCTTC	0.483													G	44105497	G	G	44105497	3	3	225	1	0	0	0	0	1	0	0	0	9513	864	30	5	663	5	MFAP1	15	44105497	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	10210145	44105497	58425895	61	15802											
STUB1	10273	broad.mit.edu	37	chr16	731823	731823	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gagtgccagcgaaaccacgaGggtgatgaggacgacagcca	15	10	0	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr16:731823G>T	uc002cit.2	+	4	966	c.555G>T	c.(553-555)GAG>GAT	p.E185D	STUB1_uc002ciu.2_Missense_Mutation_p.E113D|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA|JMJD8_uc002ciw.1_3'UTR|JMJD8_uc002cix.1_3'UTR|JMJD8_uc002ciy.1_3'UTR	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	185					cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				GAAACCACGAGGGTGATGAGG	0.637													T	731823	T	T	731823	3	4	225	1	0	0	0	0	1	0	0	0	15334	991	35	5	569	5	STUB1	16	731823	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08		731823	89622930	62	15803											
SEC14L5	9717	broad.mit.edu	37	chr16	5053502	5053502	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgattgaggtggttgaggaCaattacccagagaccctggg	14	7	0	4			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr16:5053502C>A	uc002cye.2	+	11	1410	c.1230C>A	c.(1228-1230)GAC>GAA	p.D410E		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	410	CRAL-TRIO.					integral to membrane|intracellular	transporter activity				0						TGGTTGAGGACAATTACCCAG	0.647													A	5053502	A	A	5053502	3	1	225	1	0	0	0	0	1	0	0	0	13985	477	17	5	1268	5	SEC14L5	16	5053502	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	4321679	5053502	85301251	63	15804											
SMG1	23049	broad.mit.edu	37	chr16	18875017	18875018	+	Frame_Shift_Del	DEL	GT	-	-													ggttgagggaagtgctactgGtactctttttcaagtcatgg							TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr16:18875017_18875018delGT	uc002dfm.2	-	25	4012_4013	c.3649_3650delAC	c.(3649-3651)ACCfs	p.T1217fs	SMG1_uc010bwb.2_Frame_Shift_Del_p.T1077fs	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1217	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						AGTGCTACTGGTACTCTTTTTC	0.366													-	18875018	-	-	18875017	7	5	225	1	0	1	0	1	0	0	0	0	14795	1261	44	0	7491	0	SMG1	16	18875017	Frame_Shift_Del	DEL	GT	TCGA-32-1982-01A-01D-1494-08	13821515	18875017	71479736	64	15805											
IL4R	3566	broad.mit.edu	37	chr16	27363906	27363906	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagaaccctccctccgcatcGcagccagcaccctgaagtct	7	18	1	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr16:27363906G>A	uc002don.2	+	7	801	c.559G>A	c.(559-561)GCA>ACA	p.A187T	IL4R_uc002dom.2_Missense_Mutation_p.A187T|IL4R_uc002dop.3_Missense_Mutation_p.A172T|IL4R_uc010bxy.2_Missense_Mutation_p.A187T|IL4R_uc002doo.2_Missense_Mutation_p.A27T	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	187	Extracellular (Potential).|Fibronectin type-III.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						CCTCCGCATCGCAGCCAGCAC	0.592													A	27363906	A	A	27363906	3	1	225	1	0	0	0	0	1	0	0	0	7698	1087	38	1	577	1	IL4R	16	27363906	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	8488889	27363906	62990847	65	15806											
MT1E	4493	broad.mit.edu	37	chr16	56660826	56660826	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccccgtgggctgtgccaaGtgtgcccagggctgcgtctg	16	13	1	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr16:56660826G>A	uc002ejl.2	+	3	308	c.129G>A	c.(127-129)AAG>AAA	p.K43K	MT1A_uc002eji.2_Intron|MT1M_uc010vhe.1_Intron|MT1E_uc002ejm.2_3'UTR	NM_175617	NP_783316	P04732	MT1E_HUMAN	metallothionein 1E	43	Alpha.					cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding				0						GCTGTGCCAAGTGTGCCCAGG	0.597													A	56660826	A	A	56660826	2	1	225	1	0	0	0	0	0	0	0	1	9899	1020	36	3		3	MT1E	16	56660826	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	29296920	56660826	33693927	66	15807											
SETD6	79918	broad.mit.edu	37	chr16	58552049	58552049	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taactggcaactgattcataTgtacggttttgttgaaccat	8	7	1	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr16:58552049T>C	uc002ens.2	+	6	946	c.887T>C	c.(886-888)ATG>ACG	p.M296T	SETD6_uc002enr.2_Missense_Mutation_p.M272T|SETD6_uc010cdm.2_RNA	NM_001160305	NP_001153777	Q8TBK2	SETD6_HUMAN	SET domain containing 6 isoform a	296					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			ovary(1)	1						CTGATTCATATGTACGGTTTT	0.448													C	58552049	C	C	58552049	3	2	225	1	0	0	0	0	1	0	0	0	14135	1464	51	4	909	4	SETD6	16	58552049	Missense_Mutation	SNP	T	TCGA-32-1982-01A-01D-1494-08	1891223	58552049	31802704	67	15808											
ATP6V0D1	9114	broad.mit.edu	37	chr16	67477049	67477049	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatgttcatctcgtcaaggtCctgctctgaaatgcagtcct	9	11	4	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr16:67477049C>T	uc002ete.1	-	4	614	c.514G>A	c.(514-516)GAC>AAC	p.D172N	ATP6V0D1_uc010vjo.1_Missense_Mutation_p.D213N|ATP6V0D1_uc010vjn.1_Missense_Mutation_p.D95N	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	172					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		TCGTCAAGGTCCTGCTCTGAA	0.562													T	67477049	T	T	67477049	3	4	225	1	0	0	0	0	1	0	0	0	1173	855	30	3	561	3	ATP6V0D1	16	67477049	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	8925000	67477049	22877704	68	15809											
CDH1	999	broad.mit.edu	37	chr16	68855965	68855965	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtctgatgtgaatgacaaCgcccccataccagaacctcg	8	14	1	4			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr16:68855965C>T	uc002ewg.1	+	12	1897	c.1773C>T	c.(1771-1773)AAC>AAT	p.N591N	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Silent_p.N530N	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	591	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TGAATGACAACGCCCCCATAC	0.458			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				T	68855965	T	T	68855965	2	4	225	1	0	0	0	0	0	0	0	1	3095	535	19	1		1	CDH1	16	68855965	Silent	SNP	C	TCGA-32-1982-01A-01D-1494-08	1378916	68855965	21498788	69	15810											
DNAH2	146754	broad.mit.edu	37	chr17	7663139	7663139	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacccactctgcagactttgGcaggtgtggtcaatgacatt	10	11	2	2	rs112194246		TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr17:7663139G>A	uc002giu.1	+	16	2682	c.2668G>A	c.(2668-2670)GCA>ACA	p.A890T		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	890	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCAGACTTTGGCAGGTGTGGT	0.522													A	7663139	A	A	7663139	3	1	225	1	0	0	0	0	1	0	0	0	4602	1203	42	3	2730	3	DNAH2	17	7663139	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08		7663139	73532071	70	15811											
ZNF624	57547	broad.mit.edu	37	chr17	16526500	16526500	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtataattagagaagaagaaCgcatgaaggcctttccacat	9	7	0	4			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr17:16526500C>T	uc010cpi.1	-	6	1783	c.1700G>A	c.(1699-1701)CGT>CAT	p.R567H		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	567	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AGAAGAAGAACGCATGAAGGC	0.368													T	16526500	T	T	16526500	3	4	225	1	0	0	0	0	1	0	0	0	18045	536	19	1	901	1	ZNF624	17	16526500	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	8863361	16526500	64668710	71	15812											
RAD51C	5889	broad.mit.edu	37	chr17	56772380	56772380	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaccaagatatgctggtacAtctgagtcacacaagaagtg	9	8	2	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr17:56772380A>G	uc002iwu.2	+	2	276	c.234A>G	c.(232-234)ACA>ACG	p.T78T	TEX14_uc002iwr.1_5'Flank|TEX14_uc002iws.1_5'Flank|TEX14_uc010dcz.1_5'Flank|TEX14_uc010dda.1_5'Flank|TEX14_uc010wnz.1_5'Flank|RAD51C_uc002iwt.1_Silent_p.T78T|RAD51C_uc010woa.1_Silent_p.T78T|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	78					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATGCTGGTACATCTGAGTCAC	0.398								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				G	56772380	G	G	56772380	2	3	225	1	0	0	0	0	0	0	0	1	12988	204	8	4		4	RAD51C	17	56772380	Silent	SNP	A	TCGA-32-1982-01A-01D-1494-08	40245880	56772380	24422830	72	15813											
ACE	1636	broad.mit.edu	37	chr17	61554654	61554654	+	Frame_Shift_Del	DEL	G	-	-													tgctgttccagagcgtggccGccagctgggcgcacgacacc							TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr17:61554654delG	uc002jau.1	+	1	221	c.199delG	c.(199-201)GCCfs	p.A67fs	ACE_uc010wph.1_Frame_Shift_Del_p.A67fs|ACE_uc010wpi.1_Frame_Shift_Del_p.A67fs|ACE_uc010ddu.1_5'UTR	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	67	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GAGCGTGGCCGCCAGCTGGGC	0.507													-	61554654	-	-	61554654	7	5	225	1	0	1	0	1	0	0	0	0	136	1087	38	0	201	0	ACE	17	61554654	Frame_Shift_Del	DEL	G	TCGA-32-1982-01A-01D-1494-08	4782274	61554654	19640556	73	15814											
CTDP1	9150	broad.mit.edu	37	chr18	77457977	77457977	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgagcagcactgtcagcagAtgtcgaataaagtgagtgca	12	9	1	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr18:77457977A>G	uc002lnh.1	+	4	757	c.610A>G	c.(610-612)ATG>GTG	p.M204V	CTDP1_uc002lni.1_Missense_Mutation_p.M204V|CTDP1_uc010drd.1_Missense_Mutation_p.M204V	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	204	FCP1 homology.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CTGTCAGCAGATGTCGAATAA	0.493													G	77457977	G	G	77457977	3	3	225	1	0	0	0	0	1	0	0	0	4002	333	12	4	624	4	CTDP1	18	77457977	Missense_Mutation	SNP	A	TCGA-32-1982-01A-01D-1494-08		77457977	619271	74	15815											
ATP8B3	148229	broad.mit.edu	37	chr19	1792112	1792112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaggccaggcacagtgtcCgcagggtctcctgggcaaag	15	11	1	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr19:1792112C>T	uc002ltw.2	-	19	2312	c.2078G>A	c.(2077-2079)CGG>CAG	p.R693Q	ATP8B3_uc002ltv.2_Missense_Mutation_p.R646Q|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	693	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACAGTGTCCGCAGGGTCTC	0.677													T	1792112	T	T	1792112	3	4	225	1	0	0	0	0	1	0	0	0	1196	652	23	2	1898	2	ATP8B3	19	1792112	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08		1792112	57336871	75	15816											
ADAMTS10	81794	broad.mit.edu	37	chr19	8668748	8668748	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaatcaggtactcttcctcGtctgccacgatcaggccgtg	9	14	5	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr19:8668748G>A	uc002mkj.1	-	5	730	c.456C>T	c.(454-456)GAC>GAT	p.D152D	ADAMTS10_uc002mkk.1_Translation_Start_Site	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	152					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						ACTCTTCCTCGTCTGCCACGA	0.572													A	8668748	A	A	8668748	2	1	225	1	0	0	0	0	0	0	0	1	256	1136	40	1		1	ADAMTS10	19	8668748	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	6876636	8668748	50460235	76	15817											
MUC16	94025	broad.mit.edu	37	chr19	9058871	9058871	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agttcctctgtagcactggtGgtttccacatgggacgctgc	12	11	1	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr19:9058871G>T	uc002mkp.2	-	3	28779	c.28575C>A	c.(28573-28575)ACC>ACA	p.T9525T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9527	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGCACTGGTGGTTTCCACAT	0.478													T	9058871	T	T	9058871	2	4	225	1	0	0	0	0	0	0	0	1	9973	1335	47	5		5	MUC16	19	9058871	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	390123	9058871	50070112	77	15818											
IL12RB1	3594	broad.mit.edu	37	chr19	18184347	18184347	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgctctttcagggtcagccGcctcctcccatcctggccca	8	19	3	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr19:18184347G>A	uc002nhw.1	-	8	827	c.763C>T	c.(763-765)CGG>TGG	p.R255W	IL12RB1_uc010xqb.1_Missense_Mutation_p.R255W|IL12RB1_uc002nhx.1_Missense_Mutation_p.R295W|IL12RB1_uc002nhy.2_Missense_Mutation_p.R255W	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	255	Extracellular (Potential).|Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						AGGGTCAGCCGCCTCCTCCCA	0.433													A	18184347	A	A	18184347	3	1	225	1	0	0	0	0	1	0	0	0	7626	1086	38	1	1394	1	IL12RB1	19	18184347	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	9125476	18184347	40944636	78	15819											
ZNF257	113835	broad.mit.edu	37	chr19	22271312	22271312	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ataaggtaattcatactagaGagaaaccctacaaatgtgaa	7	6	1	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr19:22271312G>A	uc010ecx.2	+	4	929	c.760G>A	c.(760-762)GAG>AAG	p.E254K	ZNF257_uc010ecy.2_Missense_Mutation_p.E222K	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCATACTAGAGAGAAACCCTA	0.388													A	22271312	A	A	22271312	3	1	225	1	0	0	0	0	1	0	0	0	17797	943	33	3	774	3	ZNF257	19	22271312	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	4086965	22271312	36857671	79	15820											
MEIS3	56917	broad.mit.edu	37	chr19	47920129	47920129	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gacgtcacctccagggggtgTccccagcccagctccggccc	12	19	1	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr19:47920129T>C	uc002pgu.2	-	3	724	c.277A>G	c.(277-279)ACA>GCA	p.T93A	MEIS3_uc002pgp.2_5'Flank|MEIS3_uc002pgq.2_Missense_Mutation_p.T174A|MEIS3_uc002pgr.2_5'UTR|MEIS3_uc002pgt.2_Missense_Mutation_p.T93A|MEIS3_uc002pgv.2_Missense_Mutation_p.T93A|MEIS3_uc002pgs.2_Missense_Mutation_p.T93A|MEIS3_uc010eld.2_Missense_Mutation_p.T93A|MEIS3_uc002pgw.2_3'UTR	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	93						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		CCAGGGGGTGTCCCCAGCCCA	0.632													C	47920129	C	C	47920129	3	2	225	1	0	0	0	0	1	0	0	0	9469	1667	58	4	1028	4	MEIS3	19	47920129	Missense_Mutation	SNP	T	TCGA-32-1982-01A-01D-1494-08	25648817	47920129	11208854	80	15821											
KLK6	5653	broad.mit.edu	37	chr19	51462468	51462468	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagttcgtgtatctgcagacGttggtgtagactcctggctt	12	9	1	2	rs148571626		TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr19:51462468G>A	uc002pui.2	-	7	947	c.687C>T	c.(685-687)AAC>AAT	p.N229N	KLK6_uc010eoj.2_Missense_Mutation_p.T101M|KLK6_uc002puh.2_Silent_p.N238N|KLK6_uc002puj.2_Silent_p.N122N|KLK6_uc010ycn.1_Silent_p.N122N|KLK6_uc002pul.2_Silent_p.N229N|KLK6_uc002pum.2_Silent_p.N122N	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	229	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		ATCTGCAGACGTTGGTGTAGA	0.547													A	51462468	A	A	51462468	2	1	225	1	0	0	0	0	0	0	0	1	8408	1136	40	1		1	KLK6	19	51462468	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	3542339	51462468	7666515	81	15822											
NLRP13	126204	broad.mit.edu	37	chr19	56423179	56423179	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagaagcttggagttcttcGtcctccaaaatattaaggtc	9	8	1	1	rs140606375	byFrequency	TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr19:56423179G>A	uc010ygg.1	-	5	2029	c.2004C>T	c.(2002-2004)GAC>GAT	p.D668D		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	668							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GGAGTTCTTCGTCCTCCAAAA	0.408													A	56423179	A	A	56423179	2	1	225	1	0	0	0	0	0	0	0	1	10475	1136	40	1		1	NLRP13	19	56423179	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	4960711	56423179	2705804	82	15823											
ZNF543	125919	broad.mit.edu	37	chr19	57840542	57840542	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaacagatgtgggaagacCttttatgactgcacagactt	10	7	0	4			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr19:57840542C>T	uc002qoi.1	+	4	2057	c.1712C>T	c.(1711-1713)CCT>CTT	p.P571L		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTGGGAAGACCTTTTATGACT	0.418													T	57840542	T	T	57840542	3	4	225	1	0	0	0	0	1	0	0	0	17973	681	24	3	1726	3	ZNF543	19	57840542	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	1417363	57840542	1288441	83	15824											
JPH2	57158	broad.mit.edu	37	chr20	42788505	42788505	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagcggaggccactggagcGttcgctcacgccgaagcccg	15	14	1	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr20:42788505G>A	uc002xli.1	-	2	1795	c.922C>T	c.(922-924)CGC>TGC	p.R308C		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	308	MORN 7.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CCACTGGAGCGTTCGCTCACG	0.672													A	42788505	A	A	42788505	3	1	225	1	0	0	0	0	1	0	0	0	7961	1145	40	1	1184	1	JPH2	20	42788505	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08		42788505	20237015	84	15825											
COL6A2	1292	broad.mit.edu	37	chr21	47545189	47545189	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcattgcaggagtgtgacGtcatgacctacgtgagggag	16	7	1	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr21:47545189G>A	uc002zia.1	+	24	1862	c.1780G>A	c.(1780-1782)GTC>ATC	p.V594I	COL6A2_uc002zhy.1_Missense_Mutation_p.V594I|COL6A2_uc002zhz.1_Missense_Mutation_p.V594I|COL6A2_uc002zib.1_5'UTR|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	594	Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GGAGTGTGACGTCATGACCTA	0.687													A	47545189	A	A	47545189	3	1	225	1	0	0	0	0	1	0	0	0	3700	1145	40	1	1870	1	COL6A2	21	47545189	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08		47545189	584706	85	15826											
CABIN1	23523	broad.mit.edu	37	chr22	24561503	24561503	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctgtatgaccgcaggaagtAtctgcgagatgctgaccgcc	12	12	1	3			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chr22:24561503A>G	uc002zzi.1	+	31	5043	c.4916A>G	c.(4915-4917)TAT>TGT	p.Y1639C	CABIN1_uc002zzj.1_Missense_Mutation_p.Y1560C|CABIN1_uc002zzl.1_Missense_Mutation_p.Y1639C|CABIN1_uc002zzm.1_Missense_Mutation_p.Y64C	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1639					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CGCAGGAAGTATCTGCGAGAT	0.612													G	24561503	G	G	24561503	3	3	225	1	0	0	0	0	1	0	0	0	2528	449	16	4	5034	4	CABIN1	22	24561503	Missense_Mutation	SNP	A	TCGA-32-1982-01A-01D-1494-08		24561503	26743063	86	15827											
CXorf59	286464	broad.mit.edu	37	chrX	36103536	36103536	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	accatttatgatgtgctgctCcatttgagtggaaaaatgcc	9	8	0	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:36103536C>T	uc004ddk.1	+	5	708	c.522C>T	c.(520-522)CTC>CTT	p.L174L		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	174						integral to membrane				central_nervous_system(1)	1						ATGTGCTGCTCCATTTGAGTG	0.353													T	36103536	T	T	36103536	2	4	225	1	0	0	0	0	0	0	0	1	4115	842	30	3		3	CXorf59	23	36103536	Silent	SNP	C	TCGA-32-1982-01A-01D-1494-08		36103536	119167024	87	15828											
HDAC6	10013	broad.mit.edu	37	chrX	48661362	48661362	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggcaaaatgaagaagctcGgccaagcaatggaagaagac	12	7	0	4			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:48661362G>A	uc011mmi.1	+	3	273	c.178G>A	c.(178-180)GGC>AGC	p.G60S	HDAC6_uc004dkr.1_Missense_Mutation_p.G60S|HDAC6_uc004dks.1_Missense_Mutation_p.G60S|HDAC6_uc010nig.1_5'UTR|HDAC6_uc004dkt.1_Missense_Mutation_p.G60S|HDAC6_uc004dku.3_Missense_Mutation_p.G60S|HDAC6_uc011mmj.1_Missense_Mutation_p.G5S|HDAC6_uc011mmk.1_Missense_Mutation_p.G41S	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	60					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	GAAGAAGCTCGGCCAAGCAAT	0.488													A	48661362	A	A	48661362	3	1	225	1	0	0	0	0	1	0	0	0	7011	1116	39	2	184	2	HDAC6	23	48661362	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	12557826	48661362	106609198	88	15829											
SMC1A	8243	broad.mit.edu	37	chrX	53439144	53439144	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcttcttgattttgtgggagGtgttctccttggctttgatg	13	6	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:53439144G>T	uc004dsg.2	-	6	983	c.914C>A	c.(913-915)ACC>AAC	p.T305N	SMC1A_uc011moe.1_Missense_Mutation_p.T283N|SMC1A_uc011mof.1_Intron	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	305	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						TTTGTGGGAGGTGTTCTCCTT	0.498													T	53439144	T	T	53439144	3	4	225	1	0	0	0	0	1	0	0	0	14781	1261	44	5	2867	5	SMC1A	23	53439144	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	4777782	53439144	101831416	89	15830											
TAF1	6872	broad.mit.edu	37	chrX	70627913	70627913	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atggacctacaaacactccgCgaaaacgtgcgtaaacgcct	8	13	0	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:70627913C>T	uc004dzu.3	+	28	4344	c.4293C>T	c.(4291-4293)CGC>CGT	p.R1431R	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Silent_p.R1452R|TAF1_uc004dzv.3_Silent_p.R605R|TAF1_uc010nld.1_RNA|TAF1_uc010nle.1_RNA|TAF1_uc010nlf.1_5'UTR|TAF1_uc004dzx.2_RNA|TAF1_uc004dzy.2_RNA	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1431	Bromo 1.|Interaction with ASF1A and ASF1B.|Protein kinase 2.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AAACACTCCGCGAAAACGTGC	0.443													T	70627913	T	T	70627913	2	4	225	1	0	0	0	0	0	0	0	1	15510	755	27	1		1	TAF1	23	70627913	Silent	SNP	C	TCGA-32-1982-01A-01D-1494-08	17188769	70627913	84642647	90	15831											
PGK1	5230	broad.mit.edu	37	chrX	77378404	77378404	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aatgagatgattattggtggTggaatggcttttaccttcct	11	5	0	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:77378404T>A	uc004ecz.3	+	7	886	c.714T>A	c.(712-714)GGT>GGA	p.G238G	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Silent_p.G210G	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	238					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						TTATTGGTGGTGGAATGGCTT	0.398													A	77378404	A	A	77378404	2	1	225	1	0	0	0	0	0	0	0	1	11790	1683	59	5		5	PGK1	23	77378404	Silent	SNP	T	TCGA-32-1982-01A-01D-1494-08	6750491	77378404	77892156	91	15832											
RPA4	29935	broad.mit.edu	37	chrX	96139791	96139791	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccgtgcatattctggaaaCggtcaatgcacacatgatgc	9	11	2	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:96139791C>T	uc004efv.3	+	1	780	c.482C>T	c.(481-483)ACG>ATG	p.T161M	DIAPH2_uc004eft.3_Intron|DIAPH2_uc004efu.3_Intron|DIAPH2_uc004efs.2_Intron	NM_013347	NP_037479	Q13156	RFA4_HUMAN	replication protein A4, 34kDa	161					DNA damage checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair	DNA replication factor A complex|nucleoplasm	single-stranded DNA binding				0						ATTCTGGAAACGGTCAATGCA	0.458								Other_identified_genes_with_known_or_suspected_DNA_repair_function					T	96139791	T	T	96139791	3	4	225	1	0	0	0	0	1	0	0	0	13539	536	19	1	484	1	RPA4	23	96139791	Missense_Mutation	SNP	C	TCGA-32-1982-01A-01D-1494-08	18761387	96139791	59130769	92	15833											
PCDH19	57526	broad.mit.edu	37	chrX	99662858	99662858	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggcgagttttctggcacGctcaccgcgtaggtggactc	15	11	2	0			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:99662858G>A	uc010nmz.2	-	1	2414	c.738C>T	c.(736-738)AGC>AGT	p.S246S	PCDH19_uc004efw.3_Silent_p.S246S|PCDH19_uc004efx.3_Silent_p.S246S	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	246	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						TTTCTGGCACGCTCACCGCGT	0.617													A	99662858	A	A	99662858	2	1	225	1	0	0	0	0	0	0	0	1	11514	1078	38	1		1	PCDH19	23	99662858	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	3523067	99662858	55607702	93	15834											
MID2	11043	broad.mit.edu	37	chrX	107084402	107084402	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccgttgcctgcgggccacGcaccccaacaagaaaccttt	9	16	0	1			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:107084402G>A	uc004enl.2	+	2	1080	c.507G>A	c.(505-507)ACG>ACA	p.T169T	MID2_uc004enk.2_Silent_p.T169T	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	169	B box-type 1; degenerate.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TGCGGGCCACGCACCCCAACA	0.552													A	107084402	A	A	107084402	2	1	225	1	0	0	0	0	0	0	0	1	9578	1074	38	1		1	MID2	23	107084402	Silent	SNP	G	TCGA-32-1982-01A-01D-1494-08	7421544	107084402	48186158	94	15835											
MAGEA6	4105	broad.mit.edu	37	chrX	151869622	151869622	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttccctgacctggagtctgaGttccaagcagcactcagtag	10	12	2	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:151869622G>T	uc004ffq.1	+	3	506	c.312G>T	c.(310-312)GAG>GAT	p.E104D	MAGEA6_uc004ffr.1_Missense_Mutation_p.E104D|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	104							protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					TGGAGTCTGAGTTCCAAGCAG	0.547													T	151869622	T	T	151869622	3	4	225	1	0	0	0	0	1	0	0	0	9170	1020	36	5	314	5	MAGEA6	23	151869622	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	44785220	151869622	3400938	95	15836											
DKC1	1736	broad.mit.edu	37	chrX	154004585	154004585	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctggtctggagagcggggccGagcctggagatggggtgtgt	21	7	1	2			TCGA-32-1982-01A-01D-1494-08	TCGA-32-1982-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	9cf7c4cb-ce19-4b79-9163-b74369603e22	a6880916-1bae-4099-ba43-11216bc81b25	g.chrX:154004585G>A	uc004fmm.2	+	14	1672	c.1462G>A	c.(1462-1464)GAG>AAG	p.E488K	DKC1_uc010nvf.2_Missense_Mutation_p.E483K	NM_001363	NP_001354	O60832	DKC1_HUMAN	dyskerin isoform 1	488	Nuclear and nucleolar localization.				cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GAGCGGGGCCGAGCCTGGAGA	0.468									Congenital_Dyskeratosis				A	154004585	A	A	154004585	3	1	225	1	0	0	0	0	1	0	0	0	4542	1059	37	2	1516	2	DKC1	23	154004585	Missense_Mutation	SNP	G	TCGA-32-1982-01A-01D-1494-08	2134963	154004585	1265975	96	15837											
KIAA0562	9731	broad.mit.edu	37	chr1	3746424	3746424	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaattgttttgtagagaatGttcctgcgtgtgttgctgtc	11	5	0	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr1:3746424G>A	uc001aky.2	-	14	2333	c.1974C>T	c.(1972-1974)AAC>AAT	p.N658N	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	658						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		TGTAGAGAATGTTCCTGCGTG	0.463													A	3746424	A	A	3746424	2	1	226	1	0	0	0	0	0	0	0	1	8184	1368	48	3		3	KIAA0562	1	3746424	Silent	SNP	G	TCGA-32-1986-01A-01D-1494-08		3746424	245504197	1	15838											
RPA2	6118	broad.mit.edu	37	chr1	28223599	28223599	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcattcatatcctccagggGcatgatcttaaaggctacca	7	12	3	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr1:28223599G>A	uc001bpe.1	-	6	724	c.442C>T	c.(442-444)CCC>TCC	p.P148S	RPA2_uc001bpd.1_Missense_Mutation_p.P156S|RPA2_uc010ofp.1_Missense_Mutation_p.P52S	NM_002946	NP_002937	P15927	RFA2_HUMAN	replication protein A2, 32kDa	148					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|regulation of double-strand break repair via homologous recombination|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor A complex|PML body	protein phosphatase binding|single-stranded DNA binding			skin(1)	1		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.62e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00294)|STAD - Stomach adenocarcinoma(196;0.00308)|BRCA - Breast invasive adenocarcinoma(304;0.00613)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTCCAGGGGCATGATCTTA	0.383								Direct_reversal_of_damage|NER					A	28223599	A	A	28223599	3	1	226	1	0	0	0	0	1	0	0	0	13537	1203	42	3	386	3	RPA2	1	28223599	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08	24477175	28223599	221027022	2	15839											
C8B	732	broad.mit.edu	37	chr1	57417728	57417728	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgtctcttacctgtggcGtgtagctttccacattgtag	11	10	1	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr1:57417728G>A	uc001cyp.2	-	5	726	c.659C>T	c.(658-660)ACG>ATG	p.T220M	C8B_uc010oon.1_Missense_Mutation_p.T158M|C8B_uc010ooo.1_Missense_Mutation_p.T168M	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	220	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TACCTGTGGCGTGTAGCTTTC	0.284													A	57417728	A	A	57417728	3	1	226	1	0	0	0	0	1	0	0	0	2417	1145	40	1	1148	1	C8B	1	57417728	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08	29194129	57417728	191832893	3	15840											
SGIP1	84251	broad.mit.edu	37	chr1	67206953	67206953	+	Splice_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtaataatgtgtttttttttAggggtgggttctttgttggc	13	2	1	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr1:67206953A>T	uc001dcr.2	+	24	2517	c.2300_splice	c.e24-2	p.G767_splice	SGIP1_uc010opd.1_Splice_Site_p.G367_splice|SGIP1_uc001dcs.2_Splice_Site_p.G367_splice|SGIP1_uc001dct.2_Splice_Site_p.G369_splice|SGIP1_uc009wat.2_Splice_Site_p.G561_splice|SGIP1_uc001dcu.2_Splice_Site_p.G272_splice	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting						positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						GTTTTTTTTTAGGGGTGGGTT	0.373													T	67206953	T	T	67206953	5	4	226	1	0	0	0	0	0	0	1	0	14206	434	15	5	2392	5	SGIP1	1	67206953	Splice_Site	SNP	A	TCGA-32-1986-01A-01D-1494-08	9789225	67206953	182043668	4	15841											
TDRD10	126668	broad.mit.edu	37	chr1	154479756	154479756	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ccccaactctctgataaactGtttgggaagaatggagtgtt	10	8	1	2			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr1:154479756G>C	uc009wow.2	+	3	880	c.42G>C	c.(40-42)CTG>CTC	p.L14L	TDRD10_uc001ffd.2_Silent_p.L14L	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	14							nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTGATAAACTGTTTGGGAAGA	0.502													C	154479756	C	C	154479756	2	2	226	1	0	0	0	0	0	0	0	1	15728	1364	48	5		5	TDRD10	1	154479756	Silent	SNP	G	TCGA-32-1986-01A-01D-1494-08	87272803	154479756	94770865	5	15842											
SLAMF7	57823	broad.mit.edu	37	chr1	160718192	160718192	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gacttcccagatggaggctaCtccctgaagctcagcaaact	9	13	1	2			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr1:160718192C>A	uc001fwq.2	+	2	279	c.264C>A	c.(262-264)TAC>TAA	p.Y88*	SLAMF7_uc010pjn.1_Intron|SLAMF7_uc001fws.2_Intron|SLAMF7_uc001fwr.2_Nonsense_Mutation_p.Y88*|SLAMF7_uc010pjo.1_Nonsense_Mutation_p.Y88*|SLAMF7_uc010pjp.1_Intron|SLAMF7_uc010pjq.1_Nonsense_Mutation_p.Y88*|SLAMF7_uc010pjr.1_Intron	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	88	Extracellular (Potential).				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATGGAGGCTACTCCCTGAAGC	0.507													A	160718192	A	A	160718192	4	1	226	1	0	0	0	0	0	1	0	0	14369	576	20	5	270	5	SLAMF7	1	160718192	Nonsense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	6238436	160718192	88532429	6	15843											
USH2A	7399	broad.mit.edu	37	chr1	216052106	216052106	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcatagtcaccttctcttacCtcaaattaggtccatttggc	5	12	4	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr1:216052106C>A	uc001hku.1	-	42	8945	c.8558G>T	c.(8557-8559)AGA>ATA	p.R2853I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2853	Extracellular (Potential).|Fibronectin type-III 15.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTTCTCTTACCTCAAATTAGG	0.393										HNSCC(13;0.011)			A	216052106	A	A	216052106	3	1	226	1	0	0	0	0	1	0	0	0	17033	695	24	5	7174	5	USH2A	1	216052106	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	55333914	216052106	33198515	7	15844											
OBSCN	84033	broad.mit.edu	37	chr1	228444458	228444458	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggctcaggcccagacggaGgtgatgtggtacaaggacgg	18	8	1	2			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr1:228444458G>A	uc009xez.1	+	15	4460	c.4416G>A	c.(4414-4416)GAG>GAA	p.E1472E	OBSCN_uc001hsn.2_Silent_p.E1472E	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1472	Ig-like 15.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCCAGACGGAGGTGATGTGGT	0.657													A	228444458	A	A	228444458	2	1	226	1	0	0	0	0	0	0	0	1	10812	991	35	3		3	OBSCN	1	228444458	Silent	SNP	G	TCGA-32-1986-01A-01D-1494-08	12392352	228444458	20806163	8	15845											
MARCO	8685	broad.mit.edu	37	chr2	119732140	119732140	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgggagtcaagggagaggcGggtgagtaggtgctgggtat	21	5	1	2			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr2:119732140G>A	uc002tln.1	+	6	744	c.612G>A	c.(610-612)GCG>GCA	p.A204A	MARCO_uc010yyf.1_Silent_p.A126A	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	204	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						AGGGAGAGGCGGGTGAGTAGG	0.572													A	119732140	A	A	119732140	2	1	226	1	0	0	0	0	0	0	0	1	9311	1130	39	2		2	MARCO	2	119732140	Silent	SNP	G	TCGA-32-1986-01A-01D-1494-08		119732140	123467233	9	15846											
C2orf80	389073	broad.mit.edu	37	chr2	209036767	209036767	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttaacatggcaaaggggtgCaaggagaggcagagagatga	17	4	0	4			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr2:209036767C>T	uc002vcr.2	-	7	571	c.399G>A	c.(397-399)TTG>TTA	p.L133L		NM_001099334	NP_001092804	Q0P641	CB080_HUMAN	hypothetical protein LOC389073	133										skin(1)	1						CAAAGGGGTGCAAGGAGAGGC	0.478													T	209036767	T	T	209036767	2	4	226	1	0	0	0	0	0	0	0	1	2197	709	25	3		3	C2orf80	2	209036767	Silent	SNP	C	TCGA-32-1986-01A-01D-1494-08	89304627	209036767	34162606	10	15847											
RNF168	165918	broad.mit.edu	37	chr3	196214417	196214417	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttcactggctttgttttcTtcttcctcgctggcccgtcg	8	14	4	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr3:196214417T>G	uc003fwq.2	-	3	949	c.411A>C	c.(409-411)GAA>GAC	p.E137D	RNF168_uc010iah.2_5'UTR	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	137	Glu-rich.				double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		CTTTGTTTTCTTCTTCCTCGC	0.433													G	196214417	G	G	196214417	3	3	226	1	0	0	0	0	1	0	0	0	13459	1606	56	5	1320	5	RNF168	3	196214417	Missense_Mutation	SNP	T	TCGA-32-1986-01A-01D-1494-08		196214417	1808013	11	15848											
PPEF2	5470	broad.mit.edu	37	chr4	76811138	76811138	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctgaatgcttctaccaggGcagttgcatggtcaggcagg	14	9	3	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr4:76811138G>A	uc003hix.2	-	5	746	c.389C>T	c.(388-390)GCC>GTC	p.A130V	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.A130V	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	130	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTCTACCAGGGCAGTTGCATG	0.522													A	76811138	A	A	76811138	3	1	226	1	0	0	0	0	1	0	0	0	12308	1203	42	3	1924	3	PPEF2	4	76811138	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08		76811138	114343138	12	15849											
FHDC1	85462	broad.mit.edu	37	chr4	153897134	153897134	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgcggaccctgaccgcctcAgagaacgagagcatgcgcaa	13	13	1	3			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr4:153897134A>G	uc003inf.2	+	11	2766	c.2691A>G	c.(2689-2691)TCA>TCG	p.S897S		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	897					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					TGACCGCCTCAGAGAACGAGA	0.692													G	153897134	G	G	153897134	2	3	226	1	0	0	0	0	0	0	0	1	5876	175	7	4		4	FHDC1	4	153897134	Silent	SNP	A	TCGA-32-1986-01A-01D-1494-08	77085996	153897134	37257142	13	15850											
FSTL5	56884	broad.mit.edu	37	chr4	162680612	162680614	+	In_Frame_Del	DEL	ATC	-	-													aggtgcttgtcagcattaaaAtcatcatatttcaatagaac							TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr4:162680612_162680614delATC	uc003iqh.2	-	6	1112_1114	c.676_678delGAT	c.(676-678)GATdel	p.D226del	FSTL5_uc003iqi.2_In_Frame_Del_p.D225del|FSTL5_uc010iqv.2_In_Frame_Del_p.D225del	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	226	2 (Potential).|EF-hand 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CAGCATTAAAATCATCATATTTC	0.34													-	162680614	-	-	162680612	7	5	226	1	0	1	0	1	0	0	0	0	6080	98	4	0	1909	0	FSTL5	4	162680612	In_Frame_Del	DEL	ATC	TCGA-32-1986-01A-01D-1494-08	8783478	162680612	28473664	14	15851											
ADCY2	108	broad.mit.edu	37	chr5	7706894	7706894	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggagttgatatcaacatgCgcgtgggcgtgcattctggg	15	8	2	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr5:7706894C>T	uc003jdz.1	+	8	1214	c.1147C>T	c.(1147-1149)CGC>TGC	p.R383C	ADCY2_uc011cmo.1_Missense_Mutation_p.R203C	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	383	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TATCAACATGCGCGTGGGCGT	0.473													T	7706894	T	T	7706894	3	4	226	1	0	0	0	0	1	0	0	0	294	768	27	1	1177	1	ADCY2	5	7706894	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08		7706894	173208366	15	15852											
C6	729	broad.mit.edu	37	chr5	41149449	41149449	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccattctaactggcggccGtcttggcaggaaccaatatg	10	13	2	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr5:41149449G>A	uc003jmk.2	-	17	2727	c.2517C>T	c.(2515-2517)GAC>GAT	p.D839D	C6_uc003jml.1_Silent_p.D839D	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	839	C5b-binding domain.|Complement control factor I module 1.|Kazal-like 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ACTGGCGGCCGTCTTGGCAGG	0.418													A	41149449	A	A	41149449	2	1	226	1	0	0	0	0	0	0	0	1	2315	1136	40	1		1	C6	5	41149449	Silent	SNP	G	TCGA-32-1986-01A-01D-1494-08	33442555	41149449	139765811	16	15853											
CSF2	1437	broad.mit.edu	37	chr5	131409540	131409540	+	Frame_Shift_Del	DEL	C	-	-													tggctgcagagcctgctgctCttgggcactgtggcctgcag							TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr5:131409540delC	uc003kwf.2	+	1	56	c.24delC	c.(22-24)CTCfs	p.L8fs		NM_000758	NP_000749	P04141	CSF2_HUMAN	colony stimulating factor 2 precursor	8					immune response|negative regulation of cytolysis|positive regulation of DNA replication|positive regulation of interleukin-23 production|positive regulation of macrophage derived foam cell differentiation|positive regulation of podosome assembly|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|growth factor activity				0		all_cancers(142;4.28e-07)|all_lung(232;2.81e-05)|Lung NSC(810;0.000693)|Lung SC(612;0.122)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Sargramostim(DB00020)	GCCTGCTGCTCTTGGGCACTG	0.597													-	131409540	-	-	131409540	7	5	226	1	0	1	0	1	0	0	0	0	3933	900	32	0	26	0	CSF2	5	131409540	Frame_Shift_Del	DEL	C	TCGA-32-1986-01A-01D-1494-08	90260091	131409540	49505720	17	15854											
PCDHB7	56129	broad.mit.edu	37	chr5	140553608	140553608	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcatcctgaagccatctgtcGaaaacttctatactctggta	6	11	4	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr5:140553608G>A	uc003lit.2	+	1	1366	c.1192G>A	c.(1192-1194)GAA>AAA	p.E398K		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	398	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCATCTGTCGAAAACTTCTA	0.493													A	140553608	A	A	140553608	3	1	226	1	0	0	0	0	1	0	0	0	11547	1059	37	2	1194	2	PCDHB7	5	140553608	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08	9144068	140553608	40361652	18	15855											
GEMIN5	25929	broad.mit.edu	37	chr5	154311130	154311130	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcattcccgttggtaatttcAgcttcttctatgagataggt	9	8	3	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr5:154311130A>G	uc003lvx.3	-	5	752	c.669T>C	c.(667-669)GCT>GCC	p.A223A	GEMIN5_uc011ddk.1_Silent_p.A222A	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	223	WD 4.				ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGGTAATTTCAGCTTCTTCTA	0.358													G	154311130	G	G	154311130	2	3	226	1	0	0	0	0	0	0	0	1	6331	175	7	4		4	GEMIN5	5	154311130	Silent	SNP	A	TCGA-32-1986-01A-01D-1494-08	13757522	154311130	26604130	19	15856											
GABRG2	2566	broad.mit.edu	37	chr5	161524703	161524703	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gacagacgtttgaaatttaaCagcaccattaaagtcctccg	7	10	0	2			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr5:161524703C>A	uc003lyz.3	+	4	745	c.387C>A	c.(385-387)AAC>AAA	p.N129K	GABRG2_uc010jjc.2_Missense_Mutation_p.N129K|GABRG2_uc003lyy.3_Missense_Mutation_p.N129K|GABRG2_uc011dej.1_Missense_Mutation_p.N34K	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	129	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		TGAAATTTAACAGCACCATTA	0.353													A	161524703	A	A	161524703	3	1	226	1	0	0	0	0	1	0	0	0	6172	477	17	5	401	5	GABRG2	5	161524703	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	7213573	161524703	19390557	20	15857											
ODZ2	57451	broad.mit.edu	37	chr5	167626105	167626105	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccctgggcagaatcccatcGtgcctgagacccaggtagga	12	14	0	2	rs140215976	by1000genomes	TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr5:167626105G>A	uc010jjd.2	+	16	3121	c.3121G>A	c.(3121-3123)GTG>ATG	p.V1041M	ODZ2_uc003lzr.3_Missense_Mutation_p.V818M|ODZ2_uc003lzt.3_Missense_Mutation_p.V414M|ODZ2_uc010jje.2_Missense_Mutation_p.V312M	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GAATCCCATCGTGCCTGAGAC	0.587													A	167626105	A	A	167626105	3	1	226	1	0	0	0	0	1	0	0	0	10835	1145	40	1	3183	1	ODZ2	5	167626105	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08	6101402	167626105	13289155	21	15858											
ADAMTS2	9509	broad.mit.edu	37	chr5	178556986	178556986	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtctgcagcgtctcccggcCgtcctcgtctctgtactccc	10	18	3	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr5:178556986C>T	uc003mjw.2	-	16	2404	c.2404G>A	c.(2404-2406)GGC>AGC	p.G802S		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	802	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GTCTCCCGGCCGTCCTCGTCT	0.602													T	178556986	T	T	178556986	3	4	226	1	0	0	0	0	1	0	0	0	265	652	23	2	1259	2	ADAMTS2	5	178556986	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	10930881	178556986	2358274	22	15859											
PCLO	27445	broad.mit.edu	37	chr7	82764629	82764629	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatcatcagcaacaggggccTtgtcctgctcagatgggaca	11	11	3	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr7:82764629T>C	uc003uhx.2	-	3	2526	c.2237A>G	c.(2236-2238)AAG>AGG	p.K746R	PCLO_uc003uhv.2_Missense_Mutation_p.K746R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	692	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AACAGGGGCCTTGTCCTGCTC	0.512													C	82764629	C	C	82764629	3	2	226	1	0	0	0	0	1	0	0	0	11583	1609	56	4	13300	4	PCLO	7	82764629	Missense_Mutation	SNP	T	TCGA-32-1986-01A-01D-1494-08		82764629	76374034	23	15860											
GRM3	2913	broad.mit.edu	37	chr7	86415655	86415655	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaactcagtgataagtcgCgctatgattactttgccagg	9	10	1	2			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr7:86415655C>T	uc003uid.2	+	3	1646	c.547C>T	c.(547-549)CGC>TGC	p.R183C	GRM3_uc010lef.2_Missense_Mutation_p.R181C|GRM3_uc010leg.2_Missense_Mutation_p.R55C|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	183	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGATAAGTCGCGCTATGATTA	0.562													T	86415655	T	T	86415655	3	4	226	1	0	0	0	0	1	0	0	0	6798	768	27	1	553	1	GRM3	7	86415655	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	3651026	86415655	72723008	24	15861											
CALD1	800	broad.mit.edu	37	chr7	134552500	134552500	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaccatggatgattttgagCgtcgcagagaacttagaagg	12	7	0	4			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr7:134552500C>T	uc003vrz.2	+	3	475	c.16C>T	c.(16-18)CGT>TGT	p.R6C	CALD1_uc003vry.2_Missense_Mutation_p.R6C|CALD1_uc003vsa.2_Missense_Mutation_p.R6C|CALD1_uc003vsb.2_Missense_Mutation_p.R6C|CALD1_uc010lmm.2_Missense_Mutation_p.R6C|CALD1_uc011kpt.1_5'UTR	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	6					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						TGATTTTGAGCGTCGCAGAGA	0.433													T	134552500	T	T	134552500	3	4	226	1	0	0	0	0	1	0	0	0	2581	768	27	1	18	1	CALD1	7	134552500	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	48136845	134552500	24586163	25	15862											
MGAM	8972	broad.mit.edu	37	chr7	141747587	141747587	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaatcttgttccccacagtcGaaagaaccctcttggtctta	7	12	3	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr7:141747587G>A	uc003vwy.2	+	22	2555	c.2501G>A	c.(2500-2502)CGA>CAA	p.R834Q		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	834	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCCCACAGTCGAAAGAACCCT	0.413													A	141747587	A	A	141747587	3	1	226	1	0	0	0	0	1	0	0	0	9541	1058	37	2	2583	2	MGAM	7	141747587	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08	7195087	141747587	17391076	26	15863											
AGAP3	116988	broad.mit.edu	37	chr7	150840450	150840450	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggagaaggaacgctggataCgggccaagtatgaacagaag	15	6	0	3			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr7:150840450C>T	uc003wjg.1	+	17	2299	c.2296C>T	c.(2296-2298)CGG>TGG	p.R766W	AGAP3_uc003wje.1_Missense_Mutation_p.R435W|AGAP3_uc003wjj.1_Missense_Mutation_p.R265W|AGAP3_uc003wjk.1_Missense_Mutation_p.R184W	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	730	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						ACGCTGGATACGGGCCAAGTA	0.622													T	150840450	T	T	150840450	3	4	226	1	0	0	0	0	1	0	0	0	369	527	19	1	2429	1	AGAP3	7	150840450	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	9092863	150840450	8298213	27	15864											
CDCA2	157313	broad.mit.edu	37	chr8	25319665	25319665	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atctgattcgtttcattgctCggcagcaaaatataaagaat	7	7	2	2	rs142497699	byFrequency	TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr8:25319665C>T	uc003xep.1	+	4	807	c.328C>T	c.(328-330)CGG>TGG	p.R110W	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_Missense_Mutation_p.R110W|CDCA2_uc003xeq.1_Missense_Mutation_p.R95W	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	110					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		TTTCATTGCTCGGCAGCAAAA	0.423													T	25319665	T	T	25319665	3	4	226	1	0	0	0	0	1	0	0	0	3086	875	31	2	338	2	CDCA2	8	25319665	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08		25319665	121044357	28	15865											
CUBN	8029	broad.mit.edu	37	chr10	16870839	16870839	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagaggatggagagctggCgttgggcccatcatagagtg	16	8	1	3	rs139051724		TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr10:16870839C>T	uc001ioo.2	-	66	10781	c.10729G>A	c.(10729-10731)GCC>ACC	p.A3577T		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3577	CUB 27.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGAGAGCTGGCGTTGGGCCCA	0.443											OREG0020047	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	16870839	T	T	16870839	3	4	226	1	0	0	0	0	1	0	0	0	4051	768	27	1	150	1	CUBN	10	16870839	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08		16870839	118663908	29	15866											
OR52M1	119772	broad.mit.edu	37	chr11	4566817	4566817	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccatctgcaacccactaCgtcatagcatggtgctcact	8	14	3	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr11:4566817C>T	uc010qyf.1	+	1	397	c.397C>T	c.(397-399)CGT>TGT	p.R133C		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	133	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAACCCACTACGTCATAGCAT	0.522													T	4566817	T	T	4566817	3	4	226	1	0	0	0	0	1	0	0	0	11126	536	19	1	399	1	OR52M1	11	4566817	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08		4566817	130439699	30	15867											
OR4S2	219431	broad.mit.edu	37	chr11	55419151	55419151	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgtacttttatgtacatgCgccctgatacgaccttttca	6	12	1	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr11:55419151C>T	uc001nhs.1	+	1	772	c.772C>T	c.(772-774)CGC>TGC	p.R258C		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				TATGTACATGCGCCCTGATAC	0.463													T	55419151	T	T	55419151	3	4	226	1	0	0	0	0	1	0	0	0	11083	768	27	1	774	1	OR4S2	11	55419151	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	50852334	55419151	79587365	31	15868											
SLC25A45	283130	broad.mit.edu	37	chr11	65143941	65143941	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagcattgacgggaaaggcGcgggcactgttgatggtgac	16	8	0	3			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr11:65143941G>A	uc001odp.1	-	6	1226	c.804C>T	c.(802-804)CGC>CGT	p.R268R	SLC25A45_uc009yqi.1_Silent_p.R206R|SLC25A45_uc001odq.1_Silent_p.R244R|SLC25A45_uc001odr.1_Silent_p.R268R|SLC25A45_uc001ods.1_Silent_p.R226R|SLC25A45_uc001odt.1_Silent_p.R226R	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	268	Helical; Name=6; (Potential).|Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						CGGGAAAGGCGCGGGCACTGT	0.617													A	65143941	A	A	65143941	2	1	226	1	0	0	0	0	0	0	0	1	14510	1074	38	1		1	SLC25A45	11	65143941	Silent	SNP	G	TCGA-32-1986-01A-01D-1494-08	9724790	65143941	69862575	32	15869											
CD3G	917	broad.mit.edu	37	chr11	118223167	118223167	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acagccaccttcaaggaaacCagttgaggaggaattgaact	10	9	1	2			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr11:118223167C>A	uc001psu.2	+	6	612	c.532C>A	c.(532-534)CAG>AAG	p.Q178K	CD3G_uc009zaa.1_Missense_Mutation_p.Q118K	NM_000073	NP_000064	P09693	CD3G_HUMAN	CD3G antigen, gamma polypeptide precursor	178	Cytoplasmic (Potential).				establishment or maintenance of cell polarity|protein complex assembly|protein transport|regulation of apoptosis|T cell activation|T cell costimulation|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	protein heterodimerization activity|receptor signaling complex scaffold activity|T cell receptor binding|transmembrane receptor activity				0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		TCAAGGAAACCAGTTGAGGAG	0.443													A	118223167	A	A	118223167	3	1	226	1	0	0	0	0	1	0	0	0	3013	595	21	5	554	5	CD3G	11	118223167	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	53079226	118223167	16783349	33	15870											
KCNA6	3742	broad.mit.edu	37	chr12	4919731	4919731	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gagctctgggccggccagggGcatcgccatcgtctccgtgt	15	14	2	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr12:4919731G>C	uc001qng.2	+	1	1390	c.524G>C	c.(523-525)GGC>GCC	p.G175A		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	175	Helical; Name=Segment S1; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CCGGCCAGGGGCATCGCCATC	0.597										HNSCC(72;0.22)			C	4919731	C	C	4919731	3	2	226	1	0	0	0	0	1	0	0	0	8007	1203	42	5	526	5	KCNA6	12	4919731	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08		4919731	128932164	34	15871											
NANOG	79923	broad.mit.edu	37	chr12	7945667	7945667	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcaaaaaaggaagacaaggtCccggtcaagaaacagaagac	11	8	1	4			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr12:7945667C>T	uc009zfy.1	+	2	489	c.273C>T	c.(271-273)GTC>GTT	p.V91V		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	91					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		AAGACAAGGTCCCGGTCAAGA	0.478													T	7945667	T	T	7945667	2	4	226	1	0	0	0	0	0	0	0	1	10150	842	30	3		3	NANOG	12	7945667	Silent	SNP	C	TCGA-32-1986-01A-01D-1494-08	3025936	7945667	125906228	35	15872											
FAM60A	58516	broad.mit.edu	37	chr12	31451078	31451078	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgagaactggaggacttagCtctgcaaatacagcagccct	10	11	1	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr12:31451078C>T	uc010sjz.1	-	2	300	c.61G>A	c.(61-63)GCT>ACT	p.A21T	FAM60A_uc001rkd.2_Missense_Mutation_p.A21T|FAM60A_uc010ska.1_Missense_Mutation_p.A21T|FAM60A_uc001rke.2_Missense_Mutation_p.A21T|FAM60A_uc010skb.1_Intron|FAM60A_uc001rkc.2_Missense_Mutation_p.A46T	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	21											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					GAGGACTTAGCTCTGCAAATA	0.418													T	31451078	T	T	31451078	3	4	226	1	0	0	0	0	1	0	0	0	5595	797	28	3	624	3	FAM60A	12	31451078	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	23505411	31451078	102400817	36	15873											
TAOK3	51347	broad.mit.edu	37	chr12	118599775	118599775	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tagctctcgggtggactcgtCgtgccggattagcatggcat	14	10	1	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr12:118599775C>T	uc001twx.2	-	18	2252	c.1957G>A	c.(1957-1959)GAC>AAC	p.D653N	TAOK3_uc001twv.2_Missense_Mutation_p.D193N|TAOK3_uc001tww.2_Missense_Mutation_p.D483N|TAOK3_uc001twy.3_Missense_Mutation_p.D653N	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	653					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGGACTCGTCGTGCCGGATT	0.507													T	118599775	T	T	118599775	3	4	226	1	0	0	0	0	1	0	0	0	15546	884	31	2	755	2	TAOK3	12	118599775	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	87148697	118599775	15252120	37	15874											
ABCB9	23457	broad.mit.edu	37	chr12	123430663	123430663	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccgcaggtacacctctgccTcctcctcctcattggcgaag	8	17	2	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr12:123430663T>G	uc001udm.3	-	6	1470	c.1160A>C	c.(1159-1161)GAG>GCG	p.E387A	ABCB9_uc010tai.1_5'Flank|ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Missense_Mutation_p.E387A|ABCB9_uc010taj.1_Missense_Mutation_p.E387A|ABCB9_uc001udp.2_Missense_Mutation_p.E387A|ABCB9_uc001udq.2_Missense_Mutation_p.E169A|ABCB9_uc001udr.2_Missense_Mutation_p.E387A	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	387	Poly-Glu.|ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		CACCTCTGCCTCCTCCTCCTC	0.602													G	123430663	G	G	123430663	3	3	226	1	0	0	0	0	1	0	0	0	48	1551	54	5	1168	5	ABCB9	12	123430663	Missense_Mutation	SNP	T	TCGA-32-1986-01A-01D-1494-08	4830888	123430663	10421232	38	15875											
FRMD6	122786	broad.mit.edu	37	chr14	52179253	52179253	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tttcccctggacaaatgttgGaaaattggtgtttgtggtaa	11	5	0	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr14:52179253G>T	uc001wzd.2	+	9	1118	c.833G>T	c.(832-834)GGA>GTA	p.G278V	FRMD6_uc001wzb.2_Missense_Mutation_p.G270V|FRMD6_uc001wzc.2_Missense_Mutation_p.G270V|FRMD6_uc001wze.2_Missense_Mutation_p.G201V|FRMD6_uc001wzf.2_5'Flank	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	278	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					ACAAATGTTGGAAAATTGGTG	0.284													T	52179253	T	T	52179253	3	4	226	1	0	0	0	0	1	0	0	0	6054	1174	41	5	839	5	FRMD6	14	52179253	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08		52179253	55170287	39	15876											
PLEKHH1	57475	broad.mit.edu	37	chr14	68026397	68026397	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaaggaatgggtgacactcAagttggcaaaggtgggttgg	16	5	2	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr14:68026397A>C	uc001xjl.1	+	5	554	c.412A>C	c.(412-414)AAG>CAG	p.K138Q		NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	138	Potential.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		GGTGACACTCAAGTTGGCAAA	0.537													C	68026397	C	C	68026397	3	2	226	1	0	0	0	0	1	0	0	0	12076	131	5	5	426	5	PLEKHH1	14	68026397	Missense_Mutation	SNP	A	TCGA-32-1986-01A-01D-1494-08	15847144	68026397	39323143	40	15877											
FBLN5	10516	broad.mit.edu	37	chr14	92403398	92403398	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggggcagctgctgggtacGgacctgagtagggggtcgag	21	7	0	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr14:92403398G>A	uc001xzx.3	-	4	745	c.272C>T	c.(271-273)CCG>CTG	p.P91L	FBLN5_uc010aud.2_Missense_Mutation_p.P96L|FBLN5_uc010aue.2_Missense_Mutation_p.P132L	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	91					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				TGCTGGGTACGGACCTgagta	0.433													A	92403398	A	A	92403398	3	1	226	1	0	0	0	0	1	0	0	0	5700	1116	39	2	1106	2	FBLN5	14	92403398	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08	24377001	92403398	14946142	41	15878											
TMCO5A	145942	broad.mit.edu	37	chr15	38233922	38233922	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctctgtgaagatcaagccctCtacataaaggtagagcttct	8	10	4	3			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr15:38233922C>T	uc001zjw.2	+	7	598	c.495C>T	c.(493-495)CTC>CTT	p.L165L	TMCO5A_uc001zjv.1_Silent_p.L165L|TMCO5A_uc010bbc.1_Silent_p.L165L	NM_152453	NP_689666	Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	165	Potential.					integral to membrane				central_nervous_system(1)	1						ATCAAGCCCTCTACATAAAGG	0.363													T	38233922	T	T	38233922	2	4	226	1	0	0	0	0	0	0	0	1	15996	900	32	3		3	TMCO5A	15	38233922	Silent	SNP	C	TCGA-32-1986-01A-01D-1494-08		38233922	64297470	42	15879											
MAP1A	4130	broad.mit.edu	37	chr15	43816806	43816806	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgggcaaagaagatgctgcTgaggagacagtcaagccagg	16	7	1	4			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr15:43816806T>C	uc001zrt.2	+	4	3602	c.3135T>C	c.(3133-3135)GCT>GCC	p.A1045A		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1045						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AAGATGCTGCTGAGGAGACAG	0.572													C	43816806	C	C	43816806	2	2	226	1	0	0	0	0	0	0	0	1	9227	1567	55	4		4	MAP1A	15	43816806	Silent	SNP	T	TCGA-32-1986-01A-01D-1494-08	5582884	43816806	58714586	43	15880											
SENP8	123228	broad.mit.edu	37	chr15	72432114	72432114	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttcatgactgctctgatcaCgtcagtttcatcagccctga	7	12	6	3			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr15:72432114C>T	uc002atp.2	+	2	249	c.150C>T	c.(148-150)CAC>CAT	p.H50H		NM_145204	NP_660205	Q96LD8	SENP8_HUMAN	SUMO/sentrin specific peptidase family member 8	50	Protease.				proteolysis		cysteine-type peptidase activity|protein binding			ovary(1)|skin(1)	2						GCTCTGATCACGTCAGTTTCA	0.478													T	72432114	T	T	72432114	2	4	226	1	0	0	0	0	0	0	0	1	14052	535	19	1		1	SENP8	15	72432114	Silent	SNP	C	TCGA-32-1986-01A-01D-1494-08	28615308	72432114	30099278	44	15881											
LRRK1	79705	broad.mit.edu	37	chr15	101528988	101528988	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgagttccctgtcatcgtgCgcttgcccctgtatgcggcc	11	14	1	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr15:101528988C>T	uc002bwr.2	+	5	902	c.583C>T	c.(583-585)CGC>TGC	p.R195C	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bwq.1_Missense_Mutation_p.R195C	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	195	ANK 4.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTCATCGTGCGCTTGCCCCT	0.607													T	101528988	T	T	101528988	3	4	226	1	0	0	0	0	1	0	0	0	9032	768	27	1	597	1	LRRK1	15	101528988	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	29096874	101528988	1002404	45	15882											
ZNF646	9726	broad.mit.edu	37	chr16	31091658	31091658	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccaagacctactccaaccGcatggccctgaaggaccacc	7	19	0	2			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr16:31091658G>A	uc002eap.2	+	2	4302	c.4013G>A	c.(4012-4014)CGC>CAC	p.R1338H		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1338	C2H2-type 24.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						TACTCCAACCGCATGGCCCTG	0.697													A	31091658	A	A	31091658	3	1	226	1	0	0	0	0	1	0	0	0	18059	1087	38	1	4015	1	ZNF646	16	31091658	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08		31091658	59263095	46	15883											
CDH13	1012	broad.mit.edu	37	chr16	83704446	83704446	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagttattgtcaatttgacaGttgaagataaggatgacccc	10	6	1	4			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr16:83704446G>A	uc002fgx.2	+	9	1273	c.1153G>A	c.(1153-1155)GTT>ATT	p.V385I	CDH13_uc010vns.1_Missense_Mutation_p.V432I|CDH13_uc010vnt.1_Missense_Mutation_p.V131I|CDH13_uc010vnu.1_Missense_Mutation_p.V346I	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	385	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CAATTTGACAGTTGAAGATAA	0.478													A	83704446	A	A	83704446	3	1	226	1	0	0	0	0	1	0	0	0	3099	1029	36	3	1187	3	CDH13	16	83704446	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08	52612788	83704446	6650307	47	15884											
MYO15A	51168	broad.mit.edu	37	chr17	18025430	18025430	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgcccaaggggggtgaaCggcgccaggcagcccctggg	17	15	0	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr17:18025430C>T	uc010vxh.1	+	2	3654	c.3316C>T	c.(3316-3318)CGG>TGG	p.R1106W		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1106	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GGGGGGTGAACGGCGCCAGGC	0.672													T	18025430	T	T	18025430	3	4	226	1	0	0	0	0	1	0	0	0	10063	527	19	1	3318	1	MYO15A	17	18025430	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08		18025430	63169780	48	15885											
TP53I13	90313	broad.mit.edu	37	chr17	27899640	27899640	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccctggccacgctctgcacaCggctgcacagaaacttccga	9	17	1	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr17:27899640C>G	uc002hee.2	+	6	1032	c.994C>G	c.(994-996)CGG>GGG	p.R332G		NM_138349	NP_612358	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	332	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane					0				READ - Rectum adenocarcinoma(3;0.236)		GCTCTGCACACGGCTGCACAG	0.682													G	27899640	G	G	27899640	3	3	226	1	0	0	0	0	1	0	0	0	16383	527	19	5	1016	5	TP53I13	17	27899640	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	9874210	27899640	53295570	49	15886											
NF1	4763	broad.mit.edu	37	chr17	29556164	29556164	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatcaacatgactggcttccTttgtgcccttgggggagtgt	13	9	1	1	rs137854566		TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr17:29556164T>C	uc002hgg.2	+	21	2864	c.2531T>C	c.(2530-2532)CTT>CCT	p.L844P	NF1_uc002hgh.2_Missense_Mutation_p.L844P|NF1_uc010csn.1_Missense_Mutation_p.L704P|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	844			L -> F (in NF1).|L -> P (in NF1).|L -> R (in NF1; sporadic).		actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ACTGGCTTCCTTTGTGCCCTT	0.517			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			C	29556164	C	C	29556164	3	2	226	1	0	0	0	0	1	0	0	0	10356	1609	56	4	2674	4	NF1	17	29556164	Missense_Mutation	SNP	T	TCGA-32-1986-01A-01D-1494-08	1656524	29556164	51639046	50	15887											
SLFN11	91607	broad.mit.edu	37	chr17	33680901	33680901	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtgctatcagcagagcatcaCagatgactcctggcttctcc	9	13	3	3			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr17:33680901C>G	uc010ctp.2	-	6	1818	c.1376G>C	c.(1375-1377)TGT>TCT	p.C459S	SLFN11_uc010ctq.2_Missense_Mutation_p.C459S|SLFN11_uc002hjh.3_Missense_Mutation_p.C459S|SLFN11_uc002hjg.3_Missense_Mutation_p.C459S|SLFN11_uc010ctr.2_Missense_Mutation_p.C459S	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	459						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CAGAGCATCACAGATGACTCC	0.488													G	33680901	G	G	33680901	3	3	226	1	0	0	0	0	1	0	0	0	14733	478	17	5	1337	5	SLFN11	17	33680901	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	4124737	33680901	47514309	51	15888											
SLFN13	146857	broad.mit.edu	37	chr17	33769128	33769128	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtgctatcagcagagcatcaCagatgactcctggcttctcc	9	13	3	3			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr17:33769128C>G	uc002hjk.1	-	3	1706	c.1376G>C	c.(1375-1377)TGT>TCT	p.C459S	SLFN13_uc010wch.1_Missense_Mutation_p.C459S|SLFN13_uc002hjl.2_Missense_Mutation_p.C459S|SLFN13_uc010ctt.2_Missense_Mutation_p.C141S|SLFN13_uc002hjm.2_Missense_Mutation_p.C128S	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	459						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CAGAGCATCACAGATGACTCC	0.527													G	33769128	G	G	33769128	3	3	226	1	0	0	0	0	1	0	0	0	14736	478	17	5	1325	5	SLFN13	17	33769128	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	88227	33769128	47426082	52	15889											
KRT34	3885	broad.mit.edu	37	chr17	39535641	39535641	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagctcgatctccagggcGttgactgtgcgtctcagctc	12	13	2	1	rs145615462		TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr17:39535641G>A	uc002hwm.2	-	5	978	c.966C>T	c.(964-966)AAC>AAT	p.N322N		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	322	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TCTCCAGGGCGTTGACTGTGC	0.597													A	39535641	A	A	39535641	2	1	226	1	0	0	0	0	0	0	0	1	8471	1136	40	1		1	KRT34	17	39535641	Silent	SNP	G	TCGA-32-1986-01A-01D-1494-08	5766513	39535641	41659569	53	15890											
DDX5	1655	broad.mit.edu	37	chr17	62496298	62496298	+	Frame_Shift_Del	DEL	T	-	-													actgtaaacaccattctgagTttttgccccaaaatctcttt							TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr17:62496298delT	uc002jek.2	-	13	1835	c.1588delA	c.(1588-1590)ACTfs	p.T530fs	DDX5_uc010deh.2_Frame_Shift_Del_p.T530fs|DDX5_uc002jej.2_Frame_Shift_Del_p.T425fs|DDX5_uc010wqa.1_Frame_Shift_Del_p.T451fs	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	530					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			CCATTCTGAGTTTTTGCCCCA	0.413			T	ETV4	prostate								-	62496298	-	-	62496298	7	5	226	1	0	1	0	1	0	0	0	0	4367	1725	60	0	260	0	DDX5	17	62496298	Frame_Shift_Del	DEL	T	TCGA-32-1986-01A-01D-1494-08	22960657	62496298	18698912	54	15891											
C1QTNF1	114897	broad.mit.edu	37	chr17	77043872	77043872	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacttcaacatgttcaccgGcaagttctactgctacgtgc	7	14	3	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr17:77043872G>A	uc002jwp.2	+	4	888	c.548G>A	c.(547-549)GGC>GAC	p.G183D	C1QTNF1_uc002jwq.2_Missense_Mutation_p.G101D|C1QTNF1_uc002jwr.3_Missense_Mutation_p.G193D|C1QTNF1_uc002jws.2_Missense_Mutation_p.G183D|C1QTNF1_uc002jwt.2_Missense_Mutation_p.G281D	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	183	C1q.					collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			ATGTTCACCGGCAAGTTCTAC	0.547													A	77043872	A	A	77043872	3	1	226	1	0	0	0	0	1	0	0	0	1962	1203	42	3	558	3	C1QTNF1	17	77043872	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08	14547574	77043872	4151338	55	15892											
KIAA0802	23255	broad.mit.edu	37	chr18	8807023	8807023	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgacaaggcggcctgggacGtggagtgggccgtgctcaag	19	10	1	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr18:8807023G>A	uc002knr.2	+	11	2711	c.2569G>A	c.(2569-2571)GTG>ATG	p.V857M	KIAA0802_uc002knq.2_Missense_Mutation_p.V816M|KIAA0802_uc002kns.2_Missense_Mutation_p.V187M	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1167	Potential.										0						GGCCTGGGACGTGGAGTGGGC	0.637													A	8807023	A	A	8807023	3	1	226	1	0	0	0	0	1	0	0	0	8194	1145	40	1	2603	1	KIAA0802	18	8807023	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08		8807023	69270225	56	15893											
NKG7	4818	broad.mit.edu	37	chr19	51875671	51875671	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gccctgttggccagaggcccGagtgagctgagtgggtggga	19	9	0	3			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr19:51875671G>A	uc002pwj.2	-	1	290	c.119C>T	c.(118-120)TCG>TTG	p.S40L	NKG7_uc002pwk.2_Missense_Mutation_p.S40L	NM_005601	NP_005592	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	40						integral to plasma membrane				central_nervous_system(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CCAGAGGCCCGAGTGAGCTGA	0.607													A	51875671	A	A	51875671	3	1	226	1	0	0	0	0	1	0	0	0	10443	1059	37	2	394	2	NKG7	19	51875671	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08		51875671	7253312	57	15894											
ITCH	83737	broad.mit.edu	37	chr20	32981637	32981637	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatgtctgacagtggatcacAacttggttcaatgggtagcc	11	8	3	1			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr20:32981637A>G	uc010geu.1	+	3	212	c.20A>G	c.(19-21)CAA>CGA	p.Q7R	ITCH_uc002xak.2_Missense_Mutation_p.Q7R|ITCH_uc010zuj.1_5'UTR	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	7	C2.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						AGTGGATCACAACTTGGTTCA	0.378													G	32981637	G	G	32981637	3	3	226	1	0	0	0	0	1	0	0	0	7868	130	5	4	22	4	ITCH	20	32981637	Missense_Mutation	SNP	A	TCGA-32-1986-01A-01D-1494-08		32981637	30043883	58	15895											
RPRD1B	58490	broad.mit.edu	37	chr20	36668949	36668949	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaatctgtccttgtggatgcTttttctcatgttgccaggta	10	8	2	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr20:36668949T>C	uc002xho.3	+	2	666	c.264T>C	c.(262-264)GCT>GCC	p.A88A		NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	88	CID.									pancreas(1)	1						TTGTGGATGCTTTTTCTCATG	0.353													C	36668949	C	C	36668949	2	2	226	1	0	0	0	0	0	0	0	1	13616	1596	56	4		4	RPRD1B	20	36668949	Silent	SNP	T	TCGA-32-1986-01A-01D-1494-08	3687312	36668949	26356571	59	15896											
HNF4A	3172	broad.mit.edu	37	chr20	43057004	43057004	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgatgcaccccatgcccacCaccccctgcaccctcacctg	6	23	1	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr20:43057004C>T	uc002xma.2	+	9	1248	c.1159C>T	c.(1159-1161)CAC>TAC	p.H387Y	HNF4A_uc002xlu.2_Missense_Mutation_p.H365Y|HNF4A_uc002xlv.2_Missense_Mutation_p.H365Y|HNF4A_uc002xlz.2_Missense_Mutation_p.H387Y|HNF4A_uc010ggq.2_Missense_Mutation_p.H380Y	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	387					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CCATGCCCACCACCCCCTGCA	0.587													T	43057004	T	T	43057004	3	4	226	1	0	0	0	0	1	0	0	0	7253	594	21	3	1371	3	HNF4A	20	43057004	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08	6388055	43057004	19968516	60	15897											
KCNB1	3745	broad.mit.edu	37	chr20	48098546	48098546	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcgaactcctcgccttcccGctcccgtagggtctcggcct	9	18	1	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr20:48098546G>A	uc002xur.1	-	1	636	c.472C>T	c.(472-474)CGG>TGG	p.R158W	KCNB1_uc002xus.1_Missense_Mutation_p.R158W	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	158	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCGCCTTCCCGCTCCCGTAGG	0.582													A	48098546	A	A	48098546	3	1	226	1	0	0	0	0	1	0	0	0	8012	1086	38	1	2112	1	KCNB1	20	48098546	Missense_Mutation	SNP	G	TCGA-32-1986-01A-01D-1494-08	5041542	48098546	14926974	61	15898											
C22orf23	84645	broad.mit.edu	37	chr22	38341090	38341090	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caggggctggagccttctgtCgtgcaggaggggcctttctt	16	10	2	0			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chr22:38341090C>T	uc003auj.1	-	5	531	c.440G>A	c.(439-441)CGA>CAA	p.R147Q	C22orf23_uc003auk.1_Missense_Mutation_p.R147Q	NM_032561	NP_115950	Q9BZE7	EVG1_HUMAN	hypothetical protein LOC84645	147											0	Melanoma(58;0.045)					AGCCTTCTGTCGTGCAGGAGG	0.562													T	38341090	T	T	38341090	3	4	226	1	0	0	0	0	1	0	0	0	2137	884	31	2	225	2	C22orf23	22	38341090	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08		38341090	12963476	62	15899											
ACRC	93953	broad.mit.edu	37	chrX	70830624	70830624	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtggtacccaaagtggcggCgctttgccaagatccagatt	12	10	0	2			TCGA-32-1986-01A-01D-1494-08	TCGA-32-1986-10A-01D-1494-08									Somatic	Phase_I	Capture				Illumina GAIIx	5afe3ffc-ba3a-49bb-9837-091b600cbb35	4b5d1529-bc8a-4cc1-a757-7ab4c079fca5	g.chrX:70830624C>T	uc004eae.2	+	11	2206	c.1705C>T	c.(1705-1707)CGC>TGC	p.R569C	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	569						nucleus				ovary(3)	3	Renal(35;0.156)					AAAGTGGCGGCGCTTTGCCAA	0.517													T	70830624	T	T	70830624	3	4	226	1	0	0	0	0	1	0	0	0	171	768	27	1	1743	1	ACRC	23	70830624	Missense_Mutation	SNP	C	TCGA-32-1986-01A-01D-1494-08		70830624	84439936	63	15900											
INPP5B	3633	broad.mit.edu	37	chr1	38345863	38345863	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctttgcggccacctgaatttTcagctatacaaaaggatggg	10	9	1	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:38345863T>C	uc001ccg.1	-	15	1529	c.1435A>G	c.(1435-1437)AAA>GAA	p.K479E	INPP5B_uc009vvk.1_Missense_Mutation_p.K420E|INPP5B_uc001ccf.1_Missense_Mutation_p.K315E|INPP5B_uc010oij.1_RNA	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	559					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ACCTGAATTTTCAGCTATACA	0.398													C	38345863	C	C	38345863	3	2	227	1	0	0	0	0	1	0	0	0	7755	1792	62	4	1346	4	INPP5B	1	38345863	Missense_Mutation	SNP	T	TCGA-32-1991-01A-01D-1353-08		38345863	210904758	1	15901											
CGN	57530	broad.mit.edu	37	chr1	151491244	151491244	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcctttggggtccaaatcaaGggggccaatgaccaaggggc	14	10	1	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:151491244G>T	uc009wmw.2	+	2	393	c.249G>T	c.(247-249)AAG>AAT	p.K83N		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	77	Head.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCCAAATCAAGGGGGCCAATG	0.592													T	151491244	T	T	151491244	3	4	227	1	0	0	0	0	1	0	0	0	3303	991	35	5	251	5	CGN	1	151491244	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	113145381	151491244	97759377	2	15902											
HRNR	388697	broad.mit.edu	37	chr1	152187646	152187646	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatagcgggaagacgaaccTgagctagatccgtgtcgttc	12	11	0	3			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:152187646T>C	uc001ezt.1	-	3	6535	c.6459A>G	c.(6457-6459)TCA>TCG	p.S2153S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2153					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAGACGAACCTGAGCTAGATC	0.607													C	152187646	C	C	152187646	2	2	227	1	0	0	0	0	0	0	0	1	7359	1567	55	4		4	HRNR	1	152187646	Silent	SNP	T	TCGA-32-1991-01A-01D-1353-08	696402	152187646	97062975	3	15903											
ABL2	27	broad.mit.edu	37	chr1	179077669	179077669	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggctggagaaggccagccCggctgctctccatcctctgg	13	14	2	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:179077669C>T	uc001gmj.3	-	12	3020	c.2733G>A	c.(2731-2733)CCG>CCA	p.P911P	ABL2_uc010pnf.1_Silent_p.P808P|ABL2_uc010png.1_Silent_p.P787P|ABL2_uc010pnh.1_Silent_p.P890P|ABL2_uc001gmg.3_Silent_p.P793P|ABL2_uc001gmi.3_Silent_p.P896P|ABL2_uc001gmh.3_Silent_p.P875P|ABL2_uc010pne.1_Silent_p.P772P	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	911	F-actin-binding (By similarity).|Pro-rich.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	AAGGCCAGCCCGGCTGCTCTC	0.607			T	ETV6	AML								T	179077669	T	T	179077669	2	4	227	1	0	0	0	0	0	0	0	1	93	639	23	2		2	ABL2	1	179077669	Silent	SNP	C	TCGA-32-1991-01A-01D-1353-08	26890023	179077669	70172952	4	15904											
C1orf26	54823	broad.mit.edu	37	chr1	185144110	185144110	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaagctcccaggtttcattAaatgtgactaggcagaaaac	9	8	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:185144110A>G	uc001grg.3	+	5	945	c.831A>G	c.(829-831)TTA>TTG	p.L277L	C1orf26_uc001grh.3_Silent_p.L277L	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	277											0						AGGTTTCATTAAATGTGACTA	0.348													G	185144110	G	G	185144110	2	3	227	1	0	0	0	0	0	0	0	1	2035	359	13	4		4	C1orf26	1	185144110	Silent	SNP	A	TCGA-32-1991-01A-01D-1353-08	6066441	185144110	64106511	5	15905											
CFH	3075	broad.mit.edu	37	chr1	196709801	196709801	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	catggtgttgtagctcacatGtcagacagttatcagtatgg	11	7	3	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:196709801G>T	uc001gtj.3	+	18	3075	c.2835G>T	c.(2833-2835)ATG>ATT	p.M945I		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	945	Sushi 16.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TAGCTCACATGTCAGACAGTT	0.353													T	196709801	T	T	196709801	3	4	227	1	0	0	0	0	1	0	0	0	3283	1377	48	5	2923	5	CFH	1	196709801	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	11565691	196709801	52540820	6	15906											
PTPRC	5788	broad.mit.edu	37	chr1	198703534	198703534	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	cagttattgtcatggtcactCgatgtgaagaaggaaacagg	12	6	2	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:198703534C>A	uc001gur.1	+	22	2431	c.2251C>A	c.(2251-2253)CGA>AGA	p.R751R	PTPRC_uc001gus.1_Silent_p.R703R|PTPRC_uc001gut.1_Silent_p.R590R|PTPRC_uc010ppg.1_Silent_p.R687R	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	751	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CATGGTCACTCGATGTGAAGA	0.423													A	198703534	A	A	198703534	2	1	227	1	0	0	0	0	0	0	0	1	12797	876	31	5		5	PTPRC	1	198703534	Silent	SNP	C	TCGA-32-1991-01A-01D-1353-08	1993733	198703534	50547087	7	15907											
SOX13	9580	broad.mit.edu	37	chr1	204086257	204086259	+	In_Frame_Del	DEL	AGC	-	-													ttccctctcccagattgcaaAgcagcagcagcagctgattc							TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:204086257_204086259delAGC	uc001ham.2	+	6	1194_1196	c.599_601delAGC	c.(598-603)AAGCAG>AAG	p.Q204del	SOX13_uc001hal.2_In_Frame_Del_p.Q204del|SOX13_uc010pqp.1_In_Frame_Del_p.Q204del|SOX13_uc010pqq.1_In_Frame_Del_p.Q71del	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	204	Gln-rich.				anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			CAGATTGCAAAGCAGCAGCAGCA	0.581													-	204086259	-	-	204086257	7	5	227	1	0	1	0	1	0	0	0	0	14944	72	3	0	617	0	SOX13	1	204086257	In_Frame_Del	DEL	AGC	TCGA-32-1991-01A-01D-1353-08	5382723	204086257	45164364	8	15908											
PIGR	5284	broad.mit.edu	37	chr1	207108974	207108974	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcctccagcagggagaggCggccctcgtactgggcctta	14	14	0	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:207108974C>T	uc001hez.2	-	5	1419	c.1235G>A	c.(1234-1236)CGC>CAC	p.R412H	PIGR_uc009xbz.2_Missense_Mutation_p.R412H	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	412	Ig-like V-type 4.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CAGGGAGAGGCGGCCCTCGTA	0.637											OREG0014186	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	207108974	T	T	207108974	3	4	227	1	0	0	0	0	1	0	0	0	11897	768	27	1	1087	1	PIGR	1	207108974	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	3022717	207108974	42141647	9	15909											
OR2M5	127059	broad.mit.edu	37	chr1	248308541	248308541	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caccttcctcttctttctggTcctggccatcttttcagtgg	7	14	5	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr1:248308541T>C	uc010pze.1	+	1	92	c.92T>C	c.(91-93)GTC>GCC	p.V31A		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			TTCTTTCTGGTCCTGGCCATC	0.507													C	248308541	C	C	248308541	3	2	227	1	0	0	0	0	1	0	0	0	11013	1667	58	4	94	4	OR2M5	1	248308541	Missense_Mutation	SNP	T	TCGA-32-1991-01A-01D-1353-08	41199567	248308541	942080	10	15910											
KCNK3	3777	broad.mit.edu	37	chr2	26950700	26950700	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagaaggggctgggcatgcGgcgcgccgacgtgtccatgg	18	11	0	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr2:26950700G>A	uc002rhn.2	+	2	612	c.449G>A	c.(448-450)CGG>CAG	p.R150Q		NM_002246	NP_002237	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	150	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGGCATGCGGCGCGCCGAC	0.652													A	26950700	A	A	26950700	3	1	227	1	0	0	0	0	1	0	0	0	8067	1116	39	2	455	2	KCNK3	2	26950700	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08		26950700	216248673	11	15911											
THADA	63892	broad.mit.edu	37	chr2	43458375	43458375	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcttgggggacgccagccGgactttgagaggagacagaa	18	8	0	3			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr2:43458375G>A	uc002rsw.3	-	38	5926	c.5574C>T	c.(5572-5574)TCC>TCT	p.S1858S	THADA_uc010far.2_Silent_p.S1053S|THADA_uc002rsx.3_Silent_p.S1858S|THADA_uc002rsy.3_RNA	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1858							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GACGCCAGCCGGACTTTGAGA	0.517													A	43458375	A	A	43458375	2	1	227	1	0	0	0	0	0	0	0	1	15837	1103	39	2		2	THADA	2	43458375	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08	16507675	43458375	199740998	12	15912											
CNTNAP5	129684	broad.mit.edu	37	chr2	125555882	125555882	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctcaggacttcgtggttgttCtgctctgcaagaatggtgag	13	8	3	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr2:125555882C>A	uc002tno.2	+	19	3563	c.3199C>A	c.(3199-3201)CTG>ATG	p.L1067M	CNTNAP5_uc010flu.2_Missense_Mutation_p.L1068M	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1067	Extracellular (Potential).|Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CGTGGTTGTTCTGCTCTGCAA	0.498													A	125555882	A	A	125555882	3	1	227	1	0	0	0	0	1	0	0	0	3650	912	32	5	3273	5	CNTNAP5	2	125555882	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	82097507	125555882	117643491	13	15913											
UBR3	130507	broad.mit.edu	37	chr2	170850840	170850840	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgttaatgtagttttgggGcagtgccgtgacaatgttga	13	5	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr2:170850840G>A	uc010zdi.1	+	26	3792	c.3792G>A	c.(3790-3792)GGG>GGA	p.G1264G	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_Silent_p.G85G|UBR3_uc002uft.3_Silent_p.G117G	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1264					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						TAGTTTTGGGGCAGTGCCGTG	0.418													A	170850840	A	A	170850840	2	1	227	1	0	0	0	0	0	0	0	1	16900	1190	42	3		3	UBR3	2	170850840	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08	45294958	170850840	72348533	14	15914											
FAM126B	285172	broad.mit.edu	37	chr2	201853144	201853144	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtttttcatggcattggcaaCctacaatgataatataagtc	7	7	1	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr2:201853144C>G	uc002uws.3	-	11	1020	c.832G>C	c.(832-834)GTT>CTT	p.V278L	FAM126B_uc002uwu.2_Missense_Mutation_p.V196L|FAM126B_uc002uwv.2_Missense_Mutation_p.V278L	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	278						intracellular				ovary(1)	1						GCATTGGCAACCTACAATGAT	0.338													G	201853144	G	G	201853144	3	3	227	1	0	0	0	0	1	0	0	0	5430	521	18	5	768	5	FAM126B	2	201853144	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	31002304	201853144	41346229	15	15915											
PLEKHM3	389072	broad.mit.edu	37	chr2	208841553	208841553	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctctgaactcctcgccacAttggcagctatcttcagagc	8	14	3	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr2:208841553A>G	uc002vcl.2	-	3	1858	c.1368T>C	c.(1366-1368)AAT>AAC	p.N456N	PLEKHM3_uc002vcm.2_Silent_p.N456N	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	456	PH 2.				intracellular signal transduction		metal ion binding			ovary(1)	1						TCCTCGCCACATTGGCAGCTA	0.522													G	208841553	G	G	208841553	2	3	227	1	0	0	0	0	0	0	0	1	12082	214	8	4		4	PLEKHM3	2	208841553	Silent	SNP	A	TCGA-32-1991-01A-01D-1353-08	6988409	208841553	34357820	16	15916											
C3orf32	51066	broad.mit.edu	37	chr3	8661576	8661576	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acacgatggtacagccacagCaataccgctcaggatagtcc	9	13	1	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr3:8661576C>A	uc003bqu.2	-	12	1286	c.1040G>T	c.(1039-1041)TGC>TTC	p.C347F	C3orf32_uc003bqz.2_Missense_Mutation_p.C347F|C3orf32_uc003bqs.1_RNA|C3orf32_uc003bqt.2_Missense_Mutation_p.C296F|C3orf32_uc011atg.1_Missense_Mutation_p.C369F|C3orf32_uc003bqv.2_Missense_Mutation_p.C296F|C3orf32_uc003bqw.2_RNA|C3orf32_uc003bqx.2_RNA|C3orf32_uc003bqy.2_Missense_Mutation_p.C347F	NM_015931	NP_057015	Q9Y2M2	CC032_HUMAN	hypothetical protein LOC51066	347										skin(1)	1						ACAGCCACAGCAATACCGCTC	0.507													A	8661576	A	A	8661576	3	1	227	1	0	0	0	0	1	0	0	0	2222	710	25	5	25	5	C3orf32	3	8661576	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08		8661576	189360854	17	15917											
CCBP2	1238	broad.mit.edu	37	chr3	42905968	42905968	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccccgcagcactacaggaCgtcgggactgggcatttcct	11	16	0	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr3:42905968C>T	uc003cme.2	+	3	153	c.-26C>T	c.(-28--24)GACGT>GATGT		CCBP2_uc003cmd.1_Translation_Start_Site|CCBP2_uc003cmf.2_Translation_Start_Site|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2						chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		CACTACAGGACGTCGGGACTG	0.527													T	42905968	T	T	42905968	1	4	227	1	0	0	0	0	0	0	0	0	2734	551	19	1		1	CCBP2	3	42905968	Translation_Start_Site	SNP	C	TCGA-32-1991-01A-01D-1353-08	34244392	42905968	155116462	18	15918											
PCNP	57092	broad.mit.edu	37	chr3	101304326	101304326	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgctccaaaaactctttcaGtagcagcagcttttaatgaa	6	9	2	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr3:101304326G>A	uc003dva.2	+	3	343	c.325G>A	c.(325-327)GTA>ATA	p.V109I	PCNP_uc003dvb.2_RNA|PCNP_uc003dvc.2_RNA|PCNP_uc003dvd.2_Missense_Mutation_p.V109I	NM_020357	NP_065090	Q8WW12	PCNP_HUMAN	PEST proteolytic signal containing nuclear	109					cell cycle|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	nucleus	protein binding				0						AACTCTTTCAGTAGCAGCAGC	0.299													A	101304326	A	A	101304326	3	1	227	1	0	0	0	0	1	0	0	0	11589	1029	36	3	335	3	PCNP	3	101304326	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	58398358	101304326	96718104	19	15919											
DNAJC19	131118	broad.mit.edu	37	chr3	180702463	180702463	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttctagtaaatctttagCttcattgattttggctgcta	6	8	3	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr3:180702463C>T	uc003fkt.2	-	6	456	c.316G>A	c.(316-318)GCT>ACT	p.A106T	DNAJC19_uc003fku.2_RNA	NM_145261	NP_660304	Q96DA6	TIM14_HUMAN	DnaJ homolog, subfamily C, member 19	106	J.|Mitochondrial matrix (Potential).				genitalia development|protein folding|protein targeting to mitochondrion|transmembrane transport|visual perception	integral to membrane|mitochondrial inner membrane	heat shock protein binding				0	all_cancers(143;3.12e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-36)|OV - Ovarian serous cystadenocarcinoma(80;1.55e-22)			AAATCTTTAGCTTCATTGATT	0.284													T	180702463	T	T	180702463	3	4	227	1	0	0	0	0	1	0	0	0	4638	797	28	3	38	3	DNAJC19	3	180702463	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	79398137	180702463	17319967	20	15920											
DRD5	1816	broad.mit.edu	37	chr4	9784083	9784083	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	accgctactgggccatctccAggcccttccgctacaagcgc	9	18	1	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr4:9784083A>T	uc003gmb.3	+	1	826	c.430A>T	c.(430-432)AGG>TGG	p.R144W		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	144	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GGCCATCTCCAGGCCCTTCCG	0.597													T	9784083	T	T	9784083	3	4	227	1	0	0	0	0	1	0	0	0	4760	179	7	5	432	5	DRD5	4	9784083	Missense_Mutation	SNP	A	TCGA-32-1991-01A-01D-1353-08		9784083	181370193	21	15921											
SEPSECS	51091	broad.mit.edu	37	chr4	25127315	25127315	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctatcttaaacatacttaCctggctccagaaacctgtct	4	12	3	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr4:25127315C>T	uc003grg.2	-	10	1424	c.1211_splice	c.e10+1	p.R404_splice	SEPSECS_uc003gri.2_Splice_Site_p.R403_splice|SEPSECS_uc003grh.2_Splice_Site_p.R325_splice	NM_153825	NP_722547	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine)						selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding				0		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	AACATACTTACCTGGCTCCAG	0.388													T	25127315	T	T	25127315	5	4	227	1	0	0	0	0	0	0	1	0	14058	521	18	3	301	3	SEPSECS	4	25127315	Splice_Site	SNP	C	TCGA-32-1991-01A-01D-1353-08	15343232	25127315	166026961	22	15922											
CCKAR	886	broad.mit.edu	37	chr4	26491828	26491828	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaagcgtctcattttcgagcCcgagttcacagggaggagtg	13	9	2	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr4:26491828C>A	uc003gse.1	-	1	215	c.62G>T	c.(61-63)GGG>GTG	p.G21V		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	21	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	ATTTTCGAGCCCGAGTTCACA	0.493													A	26491828	A	A	26491828	3	1	227	1	0	0	0	0	1	0	0	0	2880	623	22	5	1244	5	CCKAR	4	26491828	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	1364513	26491828	164662448	23	15923											
SRD5A1	6715	broad.mit.edu	37	chr5	6662995	6662995	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catggagtggtgtggctatgCcctggccagctggtctgtcc	15	11	1	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr5:6662995C>T	uc003jdw.2	+	4	819	c.629C>T	c.(628-630)GCC>GTC	p.A210V	SRD5A1_uc011cml.1_RNA|SRD5A1_uc011cmm.1_Missense_Mutation_p.A163V	NM_001047	NP_001038	P18405	S5A1_HUMAN	steroid-5-alpha-reductase 1	210	Helical; (Potential).				androgen biosynthetic process|cell differentiation|sex determination|sex differentiation	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity				0					Dutasteride(DB01126)|Finasteride(DB01216)	TGTGGCTATGCCCTGGCCAGC	0.423													T	6662995	T	T	6662995	3	4	227	1	0	0	0	0	1	0	0	0	15137	739	26	3	643	3	SRD5A1	5	6662995	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08		6662995	174252265	24	15924											
ZNF622	90441	broad.mit.edu	37	chr5	16453250	16453250	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agtatctcatcaaggagcgaTgacccactctggcacctgtt	9	12	3	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr5:16453250T>A	uc003jfq.2	-	5	1298	c.1178A>T	c.(1177-1179)CAT>CTT	p.H393L		NM_033414	NP_219482	Q969S3	ZN622_HUMAN	zinc finger protein 622	393						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						CAAGGAGCGATGACCCACTCT	0.463													A	16453250	A	A	16453250	3	1	227	1	0	0	0	0	1	0	0	0	18043	1464	51	5	263	5	ZNF622	5	16453250	Missense_Mutation	SNP	T	TCGA-32-1991-01A-01D-1353-08	9790255	16453250	164462010	25	15925											
NPR3	4883	broad.mit.edu	37	chr5	32739137	32739137	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctcaatatggaggattacGtaagtgcctgattatgagcc	12	7	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr5:32739137G>A	uc003jhv.2	+	3	1277	c.1059_splice	c.e3+1	p.Y353_splice	NPR3_uc010iuo.2_Splice_Site_p.Y137_splice|NPR3_uc011cnz.1_Splice_Site_p.Y137_splice|NPR3_uc003jhu.2_Splice_Site_p.Y353_splice	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase						osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GGAGGATTACGTAAGTGCCTG	0.408													A	32739137	A	A	32739137	5	1	227	1	0	0	0	0	0	0	1	0	10596	1159	40	1	1070	1	NPR3	5	32739137	Splice_Site	SNP	G	TCGA-32-1991-01A-01D-1353-08	16285887	32739137	148176123	26	15926											
PIK3R1	5295	broad.mit.edu	37	chr5	67591096	67591098	+	In_Frame_Del	DEL	GAA	-	-													cgagaaattgacaaacgtatGaacagcattaaaccagacct							TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr5:67591096_67591098delGAA	uc003jva.2	+	13	2249_2251	c.1689_1691delGAA	c.(1687-1692)ATGAAC>ATC	p.563_564MN>I	PIK3R1_uc003jvb.2_In_Frame_Del_p.563_564MN>I|PIK3R1_uc003jvc.2_In_Frame_Del_p.263_264MN>I|PIK3R1_uc003jvd.2_In_Frame_Del_p.293_294MN>I|PIK3R1_uc003jve.2_In_Frame_Del_p.242_243MN>I|PIK3R1_uc011crb.1_In_Frame_Del_p.233_234MN>I	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	563_564					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.N564D(3)|p.D560_S565del(1)|p.R562_M563ins13(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	ACAAACGTATGAACAGCATTAAA	0.374			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67591098	-	-	67591096	7	5	227	1	0	1	0	1	0	0	0	0	11918	1290	45	0	1865	0	PIK3R1	5	67591096	In_Frame_Del	DEL	GAA	TCGA-32-1991-01A-01D-1353-08	34851959	67591096	113324164	27	15927											
SH3RF2	153769	broad.mit.edu	37	chr5	145393623	145393623	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tccttccagctgtgtgggacAggtagggaagaaacgcctgg	15	9	0	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr5:145393623A>T	uc003lnt.2	+	5	1296	c.1058A>T	c.(1057-1059)CAG>CTG	p.Q353L	SH3RF2_uc011dbl.1_Missense_Mutation_p.Q353L	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	353							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTGTGGGACAGGTAGGGAAG	0.512													T	145393623	T	T	145393623	3	4	227	1	0	0	0	0	1	0	0	0	14259	202	7	5	1072	5	SH3RF2	5	145393623	Missense_Mutation	SNP	A	TCGA-32-1991-01A-01D-1353-08	77802527	145393623	35521637	28	15928											
DCTN4	51164	broad.mit.edu	37	chr5	150133220	150133220	+	Splice_Site	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agtcaaaacaattggcacatCtgtgacatgacaaacacaac	6	10	2	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr5:150133220C>A	uc003lsv.2	-	3	309	c.207_splice	c.e3-1	p.R69_splice	DCTN4_uc003lsu.2_Splice_Site_p.R12_splice|DCTN4_uc010jhi.2_Splice_Site_p.R69_splice|DCTN4_uc010jhj.2_Splice_Site|DCTN4_uc011dck.1_Splice_Site_p.R12_splice	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b							centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTGGCACATCTGTGACATGA	0.438													A	150133220	A	A	150133220	5	1	227	1	0	0	0	0	0	0	1	0	4309	927	32	5	1245	5	DCTN4	5	150133220	Splice_Site	SNP	C	TCGA-32-1991-01A-01D-1353-08	4739597	150133220	30782040	29	15929											
ZFAND3	60685	broad.mit.edu	37	chr6	38084429	38084429	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	acggtccgaggaaaccagtcGatctaaacagaagagtcgac	11	10	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr6:38084429G>C	uc003onx.2	+	5	858	c.443G>C	c.(442-444)CGA>CCA	p.R148P		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	148							DNA binding|zinc ion binding			ovary(1)	1						GAAACCAGTCGATCTAAACAG	0.507													C	38084429	C	C	38084429	3	2	227	1	0	0	0	0	1	0	0	0	17626	1058	37	5	461	5	ZFAND3	6	38084429	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08		38084429	133030638	30	15930											
CAPN11	11131	broad.mit.edu	37	chr6	44147870	44147870	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatgctgacttcctgcttcGggtcttcaccgagaagcaca	10	12	2	3			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr6:44147870G>A	uc003owt.1	+	14	1648	c.1610G>A	c.(1609-1611)CGG>CAG	p.R537Q	CAPN11_uc011dvn.1_Missense_Mutation_p.R191Q	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	537	Domain III.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTCCTGCTTCGGGTCTTCACC	0.577													A	44147870	A	A	44147870	3	1	227	1	0	0	0	0	1	0	0	0	2624	1116	39	2	1664	2	CAPN11	6	44147870	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	6063441	44147870	126967197	31	15931											
BCLAF1	9774	broad.mit.edu	37	chr6	136599814	136599814	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctctgtacccataaggtcGtctcattcctctattatttc	4	13	3	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr6:136599814G>A	uc003qgx.1	-	4	458	c.205C>T	c.(205-207)CGA>TGA	p.R69*	BCLAF1_uc003qgw.1_Nonsense_Mutation_p.R69*|BCLAF1_uc003qgy.1_Nonsense_Mutation_p.R67*|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Nonsense_Mutation_p.R67*	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	69					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CCATAAGGTCGTCTCATTCCT	0.433													A	136599814	A	A	136599814	4	1	227	1	0	0	0	0	0	1	0	0	1383	1153	40	1	2597	1	BCLAF1	6	136599814	Nonsense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	92451944	136599814	34515253	32	15932											
EGFR	1956	broad.mit.edu	37	chr7	55221821	55221821	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggcaaatacagctttggtGccacctgcgtgaagaagtgt	13	8	0	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr7:55221821G>A	uc003tqk.2	+	7	1111	c.865G>A	c.(865-867)GCC>ACC	p.A289T	EGFR_uc003tqh.2_Missense_Mutation_p.A289T|EGFR_uc003tqi.2_Missense_Mutation_p.A289T|EGFR_uc003tqj.2_Missense_Mutation_p.A289T|EGFR_uc010kzg.1_Missense_Mutation_p.A244T|EGFR_uc011kco.1_Missense_Mutation_p.A236T|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289T(3)|p.A289D(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAGCTTTGGTGCCACCTGCGT	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55221821	A	A	55221821	3	1	227	1	0	0	0	0	1	0	0	0	4967	1319	46	3	891	3	EGFR	7	55221821	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08		55221821	103916842	33	15933											
RNF133	168433	broad.mit.edu	37	chr7	122338474	122338474	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatgagaactcccttcttaaTtaaatggaaaatttccgtgc	6	8	1	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr7:122338474T>G	uc003vkj.1	-	1	735	c.499A>C	c.(499-501)ATT>CTT	p.I167L	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	167	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						CCCTTCTTAATTAAATGGAAA	0.423													G	122338474	G	G	122338474	3	3	227	1	0	0	0	0	1	0	0	0	13439	1493	52	5	635	5	RNF133	7	122338474	Missense_Mutation	SNP	T	TCGA-32-1991-01A-01D-1353-08	67116653	122338474	36800189	34	15934											
SMARCD3	6604	broad.mit.edu	37	chr7	150945617	150945617	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgcttttcgtggctttgCgcgcccctccggcaacttcg	11	14	0	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr7:150945617C>T	uc003wjs.2	-	1	133	c.32G>A	c.(31-33)CGC>CAC	p.R11H	SMARCD3_uc003wjt.2_Intron|SMARCD3_uc003wju.2_Intron|SMARCD3_uc011kvh.1_Missense_Mutation_p.R11H|SMARCD3_uc010lqa.1_Missense_Mutation_p.R11H	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	11					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGTGGCTTTGCGCGCCCCTCC	0.498													T	150945617	T	T	150945617	3	4	227	1	0	0	0	0	1	0	0	0	14779	768	27	1	1471	1	SMARCD3	7	150945617	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	28607143	150945617	8193046	35	15935											
DEFA4	1669	broad.mit.edu	37	chr8	6794410	6794410	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agaatagcagcgaggagggcGataatcctcatggctggggt	16	7	1	1	rs61749084	byFrequency	TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr8:6794410G>A	uc003wqu.1	-	2	63	c.12C>T	c.(10-12)ATC>ATT	p.I4I		NM_001925	NP_001916	P12838	DEF4_HUMAN	defensin, alpha 4 preproprotein	4					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				large_intestine(1)	1				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CGAGGAGGGCGATAATCCTCA	0.622													A	6794410	A	A	6794410	2	1	227	1	0	0	0	0	0	0	0	1	4391	1048	37	2		2	DEFA4	8	6794410	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08		6794410	139569612	36	15936											
NKX3-1	4824	broad.mit.edu	37	chr8	23538761	23538761	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagctgggctccagctgccCacgcagtacaggtatgggta	13	11	0	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr8:23538761C>T	uc011kzx.1	-	2	726	c.678G>A	c.(676-678)GTG>GTA	p.V226V	NKX3-1_uc003xdv.1_Intron	NM_006167	NP_006158	Q99801	NKX31_HUMAN	NK3 homeobox 1	226					negative regulation of estrogen receptor binding|negative regulation of transcription, DNA-dependent|positive regulation of cell division|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	nucleus	estrogen receptor activity|estrogen receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region sequence-specific DNA binding				0		Prostate(55;0.114)		Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)|BRCA - Breast invasive adenocarcinoma(99;0.0708)		TCCAGCTGCCCACGCAGTACA	0.542													T	23538761	T	T	23538761	2	4	227	1	0	0	0	0	0	0	0	1	10455	581	21	3		3	NKX3-1	8	23538761	Silent	SNP	C	TCGA-32-1991-01A-01D-1353-08	16744351	23538761	122825261	37	15937											
PREX2	80243	broad.mit.edu	37	chr8	68989642	68989642	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggttaacagggagattgccGcaccagagaagaggcaatga	14	7	0	4			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr8:68989642G>A	uc003xxv.1	+	15	1607	c.1580G>A	c.(1579-1581)CGC>CAC	p.R527H	PREX2_uc003xxu.1_Missense_Mutation_p.R527H|PREX2_uc011lez.1_Missense_Mutation_p.R462H	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	527	DEP 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GGAGATTGCCGCACCAGAGAA	0.438													A	68989642	A	A	68989642	3	1	227	1	0	0	0	0	1	0	0	0	12477	1087	38	1	1638	1	PREX2	8	68989642	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	45450881	68989642	77374380	38	15938											
WDYHV1	55093	broad.mit.edu	37	chr8	124442261	124442261	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caggcgagacctggagatggAcctgtgatctgggtaagaca	15	8	1	4			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr8:124442261A>G	uc003yqn.1	+	3	347	c.222A>G	c.(220-222)GGA>GGG	p.G74G	WDYHV1_uc011lij.1_Silent_p.G14G|WDYHV1_uc003yqo.1_RNA	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	74					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)|skin(1)	2						CTGGAGATGGACCTGTGATCT	0.378													G	124442261	G	G	124442261	2	3	227	1	0	0	0	0	0	0	0	1	17340	262	10	4		4	WDYHV1	8	124442261	Silent	SNP	A	TCGA-32-1991-01A-01D-1353-08	55452619	124442261	21921761	39	15939											
LRRC24	441381	broad.mit.edu	37	chr8	145748578	145748578	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gcaggcaacccgcaggtcctCacccaggttggctgtgagct	13	14	1	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr8:145748578C>G	uc003zdm.2	-	5	955	c.823G>C	c.(823-825)GAG>CAG	p.E275Q	LRRC24_uc003zdn.2_Missense_Mutation_p.E272Q|LRRC14_uc003zdk.1_3'UTR|LRRC14_uc003zdl.1_3'UTR|LRRC14_uc003zdo.2_RNA	NM_001024678	NP_001019849	Q50LG9	LRC24_HUMAN	leucine rich repeat containing 24 precursor	275	Ig-like C2-type.					integral to membrane					0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CGCAGGTCCTCACCCAGGTTG	0.682													G	145748578	G	G	145748578	3	3	227	1	0	0	0	0	1	0	0	0	8979	835	29	5	722	5	LRRC24	8	145748578	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	21306317	145748578	615444	40	15940											
KIAA1045	23349	broad.mit.edu	37	chr9	34971449	34971449	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggcactgtagagggctccGtccaggaggtacaggaggag	18	8	0	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr9:34971449G>A	uc003zvq.2	+	2	332	c.154G>A	c.(154-156)GTC>ATC	p.V52I	KIAA1045_uc003zvr.2_Missense_Mutation_p.V52I	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	52							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			AGAGGGCTCCGTCCAGGAGGT	0.647													A	34971449	A	A	34971449	3	1	227	1	0	0	0	0	1	0	0	0	8207	1145	40	1	156	1	KIAA1045	9	34971449	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08		34971449	106241982	41	15941											
C9orf64	84267	broad.mit.edu	37	chr9	86554575	86554575	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttgttcaataagctccagaaGacaatcccggatcagctcaa	7	11	3	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr9:86554575G>A	uc004anb.2	-	4	1125	c.877C>T	c.(877-879)CTT>TTT	p.L293F	C9orf64_uc004anc.2_Missense_Mutation_p.L152F	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	293											0						AGCTCCAGAAGACAATCCCGG	0.458													A	86554575	A	A	86554575	3	1	227	1	0	0	0	0	1	0	0	0	2489	942	33	3	152	3	C9orf64	9	86554575	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	51583126	86554575	54658856	42	15942											
GADD45G	10912	broad.mit.edu	37	chr9	92220750	92220750	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggctatcgtgggcgccggCgaggaggcgggtgcgccggg	23	11	0	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr9:92220750C>T	uc004aqq.2	+	3	434	c.324C>T	c.(322-324)GGC>GGT	p.G108G	GADD45G_uc004aqr.2_Silent_p.G90G	NM_006705	NP_006696	O95257	GA45G_HUMAN	growth arrest and DNA-damage-inducible, gamma	108					activation of MAPKKK activity|apoptosis|cell differentiation|DNA repair|multicellular organismal development		protein binding				0						TGGGCGCCGGCGAGGAGGCGG	0.662													T	92220750	T	T	92220750	2	4	227	1	0	0	0	0	0	0	0	1	6183	755	27	1		1	GADD45G	9	92220750	Silent	SNP	C	TCGA-32-1991-01A-01D-1353-08	5666175	92220750	48992681	43	15943											
C9orf102	375748	broad.mit.edu	37	chr9	98728904	98728904	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatattttgaagcagttcaaGgatctaaagagcatcaagga	10	5	3	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr9:98728904G>T	uc004avt.3	+	14	2429	c.2041G>T	c.(2041-2043)GGA>TGA	p.G681*	C9orf102_uc011lum.1_Nonsense_Mutation_p.G383*|C9orf102_uc010mry.1_Nonsense_Mutation_p.G383*|C9orf102_uc010mrz.2_Nonsense_Mutation_p.G492*|C9orf102_uc004avu.2_Translation_Start_Site	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	681					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				AGCAGTTCAAGGATCTAAAGA	0.408													T	98728904	T	T	98728904	4	4	227	1	0	0	0	0	0	1	0	0	2445	1001	35	5	2095	5	C9orf102	9	98728904	Nonsense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	6508154	98728904	42484527	44	15944											
DNAJC9	23234	broad.mit.edu	37	chr10	75006771	75006771	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ggcgggaccctgcatacctgGaagcggcgggtggcgtcctc	17	13	0	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr10:75006771G>C	uc001jtr.2	-	1	255	c.177C>G	c.(175-177)TTC>TTG	p.F59L	DNAJC9_uc010qkg.1_Missense_Mutation_p.F59L|MRPS16_uc010qkh.1_RNA	NM_015190	NP_056005	Q8WXX5	DNJC9_HUMAN	DnaJ homolog, subfamily C, member 9	59	J.				protein folding		heat shock protein binding|unfolded protein binding				0	Prostate(51;0.0119)					TGCATACCTGGAAGCGGCGGG	0.736													C	75006771	C	C	75006771	3	2	227	1	0	0	0	0	1	0	0	0	4656	1165	41	5	625	5	DNAJC9	10	75006771	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08		75006771	60527976	45	15945											
PTEN	5728	broad.mit.edu	37	chr10	89717636	89717636	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agtttgtggtctgccagctaAaggtgaagatatattcctcc	10	8	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr10:89717636A>T	uc001kfb.2	+	8	1692	c.661A>T	c.(661-663)AAG>TAG	p.K221*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	221	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.K221fs*2(1)|p.G165_*404del(1)|p.?(1)|p.G165_K342del(1)|p.K221*(1)|p.Q214fs*22(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTGCCAGCTAAAGGTGAAGAT	0.413		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89717636	T	T	89717636	4	4	227	1	0	0	0	0	0	1	0	0	12738	15	1	5	687	5	PTEN	10	89717636	Nonsense_Mutation	SNP	A	TCGA-32-1991-01A-01D-1353-08	14710865	89717636	45817111	46	15946											
SLC22A11	55867	broad.mit.edu	37	chr11	64337166	64337166	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catacagtgggccggctgggGgctatgatgggtcccctgat	16	10	0	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr11:64337166G>A	uc001oai.2	+	9	1799	c.1425G>A	c.(1423-1425)GGG>GGA	p.G475G	SLC22A11_uc001oaj.2_Intron|SLC22A11_uc009ypq.2_Silent_p.G367G	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	475	Helical; (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	GCCGGCTGGGGGCTATGATGG	0.612													A	64337166	A	A	64337166	2	1	227	1	0	0	0	0	0	0	0	1	14442	1219	43	3		3	SLC22A11	11	64337166	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08		64337166	70669350	47	15947											
PHLDB1	23187	broad.mit.edu	37	chr11	118521224	118521224	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgctggtttgtcttcgaccgGctcaagcgcaccctttccta	9	15	2	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr11:118521224G>A	uc001ptr.1	+	21	4199	c.3846G>A	c.(3844-3846)CGG>CGA	p.R1282R	PHLDB1_uc001pts.2_Silent_p.R1282R|PHLDB1_uc001ptt.2_Silent_p.R1235R|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_Silent_p.R1097R|PHLDB1_uc001ptw.1_Silent_p.R637R|PHLDB1_uc009zai.1_Silent_p.R318R|PHLDB1_uc001ptx.1_Silent_p.R318R	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	1282	PH.										0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TCTTCGACCGGCTCAAGCGCA	0.572													A	118521224	A	A	118521224	2	1	227	1	0	0	0	0	0	0	0	1	11851	1190	42	3		3	PHLDB1	11	118521224	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08	54184058	118521224	16485292	48	15948											
VPS26B	112936	broad.mit.edu	37	chr11	134104939	134104939	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tcctacacagggcagaatgtGaagctacggtaagtgatgtc	12	8	0	3			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr11:134104939G>T	uc001qhe.2	+	2	828	c.372G>T	c.(370-372)GTG>GTT	p.V124V		NM_052875	NP_443107	Q4G0F5	VP26B_HUMAN	vacuolar protein sorting 26 homolog B	124					protein transport|vacuolar transport	cytosol|retromer complex					0	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;2.43e-10)|all cancers(11;2.94e-09)|BRCA - Breast invasive adenocarcinoma(10;9.57e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00164)|Lung(977;0.216)		GGCAGAATGTGAAGCTACGGT	0.562													T	134104939	T	T	134104939	2	4	227	1	0	0	0	0	0	0	0	1	17195	1277	45	5		5	VPS26B	11	134104939	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08	15583715	134104939	901577	49	15949											
NANOG	79923	broad.mit.edu	37	chr12	7945568	7945568	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcctcttccttcctccatGgatctgcttattcaggacag	6	14	4	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr12:7945568G>A	uc009zfy.1	+	2	390	c.174G>A	c.(172-174)ATG>ATA	p.M58I		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	58					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		CTTCCTCCATGGATCTGCTTA	0.388													A	7945568	A	A	7945568	3	1	227	1	0	0	0	0	1	0	0	0	10150	1348	47	3	180	3	NANOG	12	7945568	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08		7945568	125906327	50	15950											
KLRK1	22914	broad.mit.edu	37	chr12	10539553	10539553	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatctttgcttttgccatcGtgttgaaaaatcactcttct	5	10	4	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr12:10539553G>A	uc009zhj.2	-	3	261	c.97C>T	c.(97-99)CGA>TGA	p.R33*	uc001qya.1_Intron|KLRK1_uc001qyb.2_RNA|KLRK1_uc001qyc.2_Nonsense_Mutation_p.R33*|KLRK1_uc009zhk.2_Nonsense_Mutation_p.R33*|KLRK1_uc001qyd.2_Nonsense_Mutation_p.R33*	NM_007360	NP_031386	P26718	NKG2D_HUMAN	NKG2-D type II integral membrane protein	33	Cytoplasmic (Potential).				natural killer cell activation|T cell costimulation	integral to plasma membrane	sugar binding				0						TTTTGCCATCGTGTTGAAAAA	0.343													A	10539553	A	A	10539553	4	1	227	1	0	0	0	0	0	1	0	0	8423	1153	40	1	577	1	KLRK1	12	10539553	Nonsense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	2593985	10539553	123312342	51	15951											
GRIN2B	2904	broad.mit.edu	37	chr12	13906747	13906747	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagggaaataggtggtgaCgatagaaaagatgtaccagt	14	5	0	3			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr12:13906747C>T	uc001rbt.2	-	3	693	c.514G>A	c.(514-516)GTC>ATC	p.V172I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	172	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TAGGTGGTGACGATAGAAAAG	0.463													T	13906747	T	T	13906747	3	4	227	1	0	0	0	0	1	0	0	0	6780	536	19	1	3984	1	GRIN2B	12	13906747	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	3367194	13906747	119945148	52	15952											
ESPL1	9700	broad.mit.edu	37	chr12	53662559	53662559	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctctccggtgtcatgaggagCttcaaaagagtcaactttgg	11	9	4	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr12:53662559C>A	uc001sck.2	+	2	100	c.9C>A	c.(7-9)AGC>AGA	p.S3R	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	3					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						TCATGAGGAGCTTCAAAAGAG	0.527													A	53662559	A	A	53662559	3	1	227	1	0	0	0	0	1	0	0	0	5253	796	28	5	11	5	ESPL1	12	53662559	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	39755812	53662559	80189336	53	15953											
KIAA0564	23078	broad.mit.edu	37	chr13	42142433	42142433	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	accgaccagctggtaaagttCtctgaagcctgccaggatgg	12	11	1	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr13:42142433C>A	uc001uyj.2	-	45	5688	c.5618G>T	c.(5617-5619)AGA>ATA	p.R1873I		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1873	VWFA.					extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		TGGTAAAGTTCTCTGAAGCCT	0.502													A	42142433	A	A	42142433	3	1	227	1	0	0	0	0	1	0	0	0	8185	913	32	5	103	5	KIAA0564	13	42142433	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08		42142433	73027445	54	15954											
C14orf49	161176	broad.mit.edu	37	chr14	95932331	95932331	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctgggcatcttcgtccacGctggggtccccgatcctgtt	11	14	2	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr14:95932331G>A	uc001yei.3	-	3	579	c.564C>T	c.(562-564)AGC>AGT	p.S188S	C14orf49_uc010avi.2_Silent_p.S188S|C14orf49_uc001yej.1_Silent_p.S188S	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	188	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CTTCGTCCACGCTGGGGTCCC	0.607													A	95932331	A	A	95932331	2	1	227	1	0	0	0	0	0	0	0	1	1776	1078	38	1		1	C14orf49	14	95932331	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08		95932331	11417209	55	15955											
CHRFAM7A	89832	broad.mit.edu	37	chr15	30664456	30664456	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgaggccatagtagagcgtCctgcggcgcatggtcactgt	14	10	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr15:30664456C>T	uc001zdt.1	-	7	983	c.417G>A	c.(415-417)AGG>AGA	p.R139R	DKFZP434L187_uc001zds.2_Intron|CHRFAM7A_uc001zdu.1_Silent_p.R48R|CHRFAM7A_uc010azn.2_Silent_p.R48R	NM_139320	NP_647536	Q494W8	CRFM7_HUMAN	CHRNA7-FAM7A fusion isoform 1	139						integral to membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity			skin(1)	1		all_lung(180;3.42e-11)|Breast(32;0.000153)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		AGTAGAGCGTCCTGCGGCGCA	0.572													T	30664456	T	T	30664456	2	4	227	1	0	0	0	0	0	0	0	1	3375	854	30	3		3	CHRFAM7A	15	30664456	Silent	SNP	C	TCGA-32-1991-01A-01D-1353-08		30664456	71866936	56	15956											
RYR3	6263	broad.mit.edu	37	chr15	33952594	33952594	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtgcctggagcccctgcagaTgatggcgctccacatccccg	12	16	0	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr15:33952594T>A	uc001zhi.2	+	34	4662	c.4592T>A	c.(4591-4593)ATG>AAG	p.M1531K	RYR3_uc010bar.2_Missense_Mutation_p.M1531K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1531	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCCCTGCAGATGATGGCGCTC	0.672													A	33952594	A	A	33952594	3	1	227	1	0	0	0	0	1	0	0	0	13770	1464	51	5	4726	5	RYR3	15	33952594	Missense_Mutation	SNP	T	TCGA-32-1991-01A-01D-1353-08	3288138	33952594	68578798	57	15957											
WDR72	256764	broad.mit.edu	37	chr15	53998128	53998128	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaggaaactgacttacctctAggagaaccatcaaacttgga	8	9	2	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr15:53998128A>G	uc002acj.2	-	10	1140	c.1098T>C	c.(1096-1098)CCT>CCC	p.P366P	WDR72_uc010bfi.1_Silent_p.P366P	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	366										lung(1)|skin(1)	2				all cancers(107;0.0511)		ACTTACCTCTAGGAGAACCAT	0.383													G	53998128	G	G	53998128	2	3	227	1	0	0	0	0	0	0	0	1	17319	407	15	4		4	WDR72	15	53998128	Silent	SNP	A	TCGA-32-1991-01A-01D-1353-08	20045534	53998128	48533264	58	15958											
PCSK6	5046	broad.mit.edu	37	chr15	101972225	101972225	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgttggaccaaatggggtcGttgaagtaaagggcctgcgg	16	6	0	1	rs117473739	by1000genomes	TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr15:101972225G>A	uc002bwy.2	-	4	797	c.483C>T	c.(481-483)AAC>AAT	p.N161N	PCSK6_uc010bpd.2_Silent_p.N31N|PCSK6_uc010bpe.2_Silent_p.N161N|PCSK6_uc002bxa.2_Silent_p.N161N|PCSK6_uc002bxb.2_Silent_p.N161N|PCSK6_uc002bxc.1_Silent_p.N161N|PCSK6_uc002bxd.1_Silent_p.N161N|PCSK6_uc002bxe.2_Silent_p.N161N|PCSK6_uc002bxg.1_Silent_p.N161N	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	161	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AAATGGGGTCGTTGAAGTAAA	0.512													A	101972225	A	A	101972225	2	1	227	1	0	0	0	0	0	0	0	1	11604	1136	40	1		1	PCSK6	15	101972225	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08	47974097	101972225	559167	59	15959											
TSC2	7249	broad.mit.edu	37	chr16	2134267	2134267	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caggaggagaagtcgctccaCgcggaggagctggttggcag	18	9	0	1	rs137854084		TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr16:2134267C>A	uc002con.2	+	34	4150	c.4044C>A	c.(4042-4044)CAC>CAA	p.H1348Q	TSC2_uc010bsd.2_Missense_Mutation_p.H1325Q|TSC2_uc002coo.2_Missense_Mutation_p.H1281Q|TSC2_uc010uvv.1_Missense_Mutation_p.H1245Q|TSC2_uc010uvw.1_Missense_Mutation_p.H1233Q|TSC2_uc002cop.2_Missense_Mutation_p.H1104Q|TSC2_uc002coq.2_Missense_Mutation_p.H123Q|TSC2_uc002cor.2_Missense_Mutation_p.H49Q	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1348					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				AGTCGCTCCACGCGGAGGAGC	0.657			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				A	2134267	A	A	2134267	3	1	227	1	0	0	0	0	1	0	0	0	16603	535	19	5	4174	5	TSC2	16	2134267	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08		2134267	88220486	60	15960											
CHD9	80205	broad.mit.edu	37	chr16	53190198	53190198	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tccaacacatcagaagatgaCtgattttgaacagttaaatc	6	8	1	5			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr16:53190198C>A	uc002ehb.2	+	1	361	c.197C>A	c.(196-198)ACT>AAT	p.T66N	CHD9_uc002egy.2_Missense_Mutation_p.T66N|CHD9_uc002egz.1_Missense_Mutation_p.T66N|CHD9_uc002eha.1_Missense_Mutation_p.T66N|CHD9_uc002ehc.2_Missense_Mutation_p.T66N	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	66					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CAGAAGATGACTGATTTTGAA	0.363													A	53190198	A	A	53190198	3	1	227	1	0	0	0	0	1	0	0	0	3332	565	20	5	199	5	CHD9	16	53190198	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	51055931	53190198	37164555	61	15961											
SLC38A7	55238	broad.mit.edu	37	chr16	58705012	58705012	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tgagatcaccttgccgatgtCagggatgaagagcgccagca	13	10	2	3			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr16:58705012C>G	uc002eod.1	-	10	1561	c.1168G>C	c.(1168-1170)GAC>CAC	p.D390H	SLC38A7_uc002eob.1_RNA|SLC38A7_uc002eoc.1_Intron|SLC38A7_uc010vil.1_Missense_Mutation_p.D301H	NM_018231	NP_060701	Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	390	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)	1						TTGCCGATGTCAGGGATGAAG	0.667													G	58705012	G	G	58705012	3	3	227	1	0	0	0	0	1	0	0	0	14609	826	29	5	232	5	SLC38A7	16	58705012	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	5514814	58705012	31649741	62	15962											
B3GNT9	84752	broad.mit.edu	37	chr16	67183810	67183810	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtgtcgtcgaaggcccagagCaggatgtccgcatacgcaag	14	11	0	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr16:67183810C>A	uc002erf.2	-	2	900	c.579G>T	c.(577-579)CTG>CTT	p.L193L	uc002erg.1_Missense_Mutation_p.S71R	NM_033309	NP_171608	Q6UX72	B3GN9_HUMAN	UDP-GlcNAc:betaGal	193	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0						AGGCCCAGAGCAGGATGTCCG	0.642													A	67183810	A	A	67183810	2	1	227	1	0	0	0	0	0	0	0	1	1264	697	25	5		5	B3GNT9	16	67183810	Silent	SNP	C	TCGA-32-1991-01A-01D-1353-08	8478798	67183810	23170943	63	15963											
B3GNT9	84752	broad.mit.edu	37	chr16	67184087	67184087	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgcggcacttgtgcggctggTtaatgagcagtggaaaccgc	15	10	0	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr16:67184087T>G	uc002erf.2	-	2	623	c.302A>C	c.(301-303)AAC>ACC	p.N101T	uc002erg.1_Missense_Mutation_p.L164V	NM_033309	NP_171608	Q6UX72	B3GN9_HUMAN	UDP-GlcNAc:betaGal	101	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0						GTGCGGCTGGTTAATGAGCAG	0.672													G	67184087	G	G	67184087	3	3	227	1	0	0	0	0	1	0	0	0	1264	1725	60	5	910	5	B3GNT9	16	67184087	Missense_Mutation	SNP	T	TCGA-32-1991-01A-01D-1353-08	277	67184087	23170666	64	15964											
RICH2	9912	broad.mit.edu	37	chr17	12887884	12887884	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accgattccacccaaggtccCctttggccagccgggggcta	11	16	0	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr17:12887884C>A	uc002gnr.3	+	20	2303	c.1976C>A	c.(1975-1977)CCC>CAC	p.P659H	RICH2_uc010vvk.1_Missense_Mutation_p.P659H|RICH2_uc010vvl.1_Missense_Mutation_p.P653H|RICH2_uc002gns.3_Missense_Mutation_p.P453H|RICH2_uc010vvm.1_Missense_Mutation_p.P653H|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	659					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						CCCAAGGTCCCCTTTGGCCAG	0.582													A	12887884	A	A	12887884	3	1	227	1	0	0	0	0	1	0	0	0	13357	623	22	5	2054	5	RICH2	17	12887884	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08		12887884	68307326	65	15965											
NEUROD2	4761	broad.mit.edu	37	chr17	37762281	37762281	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgacagacccttgcacagaGtctgcacgtaggacactagg	12	12	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr17:37762281G>A	uc002hry.2	-	2	772	c.572C>T	c.(571-573)ACT>ATT	p.T191I		NM_006160	NP_006151	Q15784	NDF2_HUMAN	neurogenic differentiation 2	191					cellular response to calcium ion|cellular response to electrical stimulus|cerebellar cortex development|negative regulation of synapse maturation|positive regulation of calcium-mediated signaling|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of synapse maturation|positive regulation of synaptic plasticity|protein ubiquitination|regulation of transcription from RNA polymerase II promoter	nucleus	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Lung(15;0.00549)|LUAD - Lung adenocarcinoma(14;0.0664)			CTTGCACAGAGTCTGCACGTA	0.622													A	37762281	A	A	37762281	3	1	227	1	0	0	0	0	1	0	0	0	10349	1029	36	3	580	3	NEUROD2	17	37762281	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	24874397	37762281	43432929	66	15966											
ZNF516	9658	broad.mit.edu	37	chr18	74090999	74090999	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggctgggcctgcaaggccGcgtcgcccctggaccccgca	15	18	0	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr18:74090999G>A	uc010dqx.1	-	3	3306	c.3071C>T	c.(3070-3072)GCG>GTG	p.A1024V	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	1024					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CTGCAAGGCCGCGTCGCCCCT	0.721													A	74090999	A	A	74090999	3	1	227	1	0	0	0	0	1	0	0	0	17957	1087	38	1	437	1	ZNF516	18	74090999	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08		74090999	3986249	67	15967											
EVI5L	115704	broad.mit.edu	37	chr19	7928493	7928493	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgcgcgatgcgcgcttcttcCgccgtctggagcggccggcc	15	17	2	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr19:7928493C>A	uc002min.2	+	19	2444	c.2290C>A	c.(2290-2292)CGC>AGC	p.R764S	EVI5L_uc010xjz.1_Missense_Mutation_p.R775S	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	764						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GCGCTTCTTCCGCCGTCTGGA	0.687													A	7928493	A	A	7928493	3	1	227	1	0	0	0	0	1	0	0	0	5290	652	23	5	2397	5	EVI5L	19	7928493	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08		7928493	51200490	68	15968											
CILP2	148113	broad.mit.edu	37	chr19	19654993	19654993	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgatcctcgaggtgccggcGtgtaccacgaggtcaaggcc	14	12	1	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr19:19654993G>A	uc002nmv.3	+	8	1724	c.1639G>A	c.(1639-1641)GTG>ATG	p.V547M	CILP2_uc002nmw.3_Missense_Mutation_p.V553M	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	547						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						AGGTGCCGGCGTGTACCACGA	0.622													A	19654993	A	A	19654993	3	1	227	1	0	0	0	0	1	0	0	0	3430	1145	40	1	1669	1	CILP2	19	19654993	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	11726500	19654993	39473990	69	15969											
PSG3	5671	broad.mit.edu	37	chr19	43233959	43233959	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagggtgactgggtaactgCggatgccaccatatcggtcc	13	11	1	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr19:43233959C>T	uc002oue.2	-	4	1091	c.959G>A	c.(958-960)CGC>CAC	p.R320H	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Missense_Mutation_p.R342H	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	320	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TGGGTAACTGCGGATGCCACC	0.493													T	43233959	T	T	43233959	3	4	227	1	0	0	0	0	1	0	0	0	12656	768	27	1	339	1	PSG3	19	43233959	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	23578966	43233959	15895024	70	15970											
RUVBL2	10856	broad.mit.edu	37	chr19	49510608	49510608	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggtggagatccagattgatCgaccagcaacagggacggtg	15	8	0	3			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr19:49510608C>T	uc002plr.1	+	6	458	c.445C>T	c.(445-447)CGA>TGA	p.R149*	RUVBL2_uc002plq.1_Nonsense_Mutation_p.R104*|RUVBL2_uc010yab.1_Nonsense_Mutation_p.R149*|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Nonsense_Mutation_p.R104*|RUVBL2_uc010yac.1_Nonsense_Mutation_p.R104*	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	149					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		CCAGATTGATCGACCAGCAAC	0.587													T	49510608	T	T	49510608	4	4	227	1	0	0	0	0	0	1	0	0	13753	876	31	2	467	2	RUVBL2	19	49510608	Nonsense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	6276649	49510608	9618375	71	15971											
LHB	3972	broad.mit.edu	37	chr19	49519328	49519328	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ggctgcggggagggtctttaGaggaagaggaggcctgagag	21	5	1	3			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr19:49519328G>T	uc002plt.2	-	3	432	c.423C>A	c.(421-423)CTC>CTA	p.L141L		NM_000894	NP_000885	P01229	LSHB_HUMAN	luteinizing hormone beta subunit precursor	141					cell-cell signaling|cellular nitrogen compound metabolic process|male gonad development|peptide hormone processing|progesterone biosynthetic process|signal transduction	extracellular region|soluble fraction	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Lutropin alfa(DB00044)|Menotropins(DB00032)	AGGGTCTTTAGAGGAAGAGGA	0.622													T	49519328	T	T	49519328	2	4	227	1	0	0	0	0	0	0	0	1	8761	929	33	5		5	LHB	19	49519328	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08	8720	49519328	9609655	72	15972											
AP2A1	160	broad.mit.edu	37	chr19	50270423	50270423	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaagggcgatgggatgcgGgggctcgcggtgttcatctc	17	10	2	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr19:50270423G>A	uc002ppn.2	+	1	244	c.33G>A	c.(31-33)CGG>CGA	p.R11R	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Silent_p.R11R	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	11					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		ATGGGATGCGGGGGCTCGCGG	0.706													A	50270423	A	A	50270423	2	1	227	1	0	0	0	0	0	0	0	1	739	1219	43	3		3	AP2A1	19	50270423	Silent	SNP	G	TCGA-32-1991-01A-01D-1353-08	751095	50270423	8858560	73	15973											
CEACAM18	729767	broad.mit.edu	37	chr19	51981792	51981792	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccgccctgaaggctgggagaCgagaccggcagcctctgtgc	15	14	1	3	rs140323408	by1000genomes	TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr19:51981792C>G	uc002pwv.1	+	2	79	c.79C>G	c.(79-81)CGA>GGA	p.R27G		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	27						integral to membrane		p.R27*(1)		skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GGCTGGGAGACGAGACCGGCA	0.647													G	51981792	G	G	51981792	3	3	227	1	0	0	0	0	1	0	0	0	3189	528	19	5	85	5	CEACAM18	19	51981792	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	1711369	51981792	7147191	74	15974											
PRKCG	5582	broad.mit.edu	37	chr19	54395012	54395012	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagctcatcccagaccctcGgaacctgacgaaacagaaga	9	13	1	4			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr19:54395012G>A	uc002qcq.1	+	6	896	c.614G>A	c.(613-615)CGG>CAG	p.R205Q	PRKCG_uc010eqz.1_Missense_Mutation_p.R205Q|PRKCG_uc010yef.1_Missense_Mutation_p.R205Q|PRKCG_uc010yeg.1_Missense_Mutation_p.R205Q|PRKCG_uc010yeh.1_Missense_Mutation_p.R92Q	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	205	C2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCAGACCCTCGGAACCTGACG	0.532													A	54395012	A	A	54395012	3	1	227	1	0	0	0	0	1	0	0	0	12512	1116	39	2	636	2	PRKCG	19	54395012	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	2413220	54395012	4733971	75	15975											
NLRP2	55655	broad.mit.edu	37	chr19	55494705	55494705	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccggagtagaaagactcaggAaccccgacctgatccaagca	10	13	1	3			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr19:55494705A>T	uc002qij.2	+	6	1725	c.1639A>T	c.(1639-1641)AAC>TAC	p.N547Y	NLRP2_uc010yfp.1_Missense_Mutation_p.N524Y|NLRP2_uc010esn.2_Missense_Mutation_p.N523Y|NLRP2_uc010eso.2_Missense_Mutation_p.N544Y|NLRP2_uc010esp.2_Missense_Mutation_p.N525Y	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	547					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AAGACTCAGGAACCCCGACCT	0.567													T	55494705	T	T	55494705	3	4	227	1	0	0	0	0	1	0	0	0	10477	246	9	5	1657	5	NLRP2	19	55494705	Missense_Mutation	SNP	A	TCGA-32-1991-01A-01D-1353-08	1099693	55494705	3634278	76	15976											
CEBPB	1051	broad.mit.edu	37	chr20	48807614	48807614	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagcatgtctccccctgcCgccgccgccgcctgccttta	8	22	1	0			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr20:48807614C>T	uc002xvi.1	+	1	239	c.44C>T	c.(43-45)CCG>CTG	p.P15L	CEBPB_uc002xvh.2_RNA	NM_005194	NP_005185	P17676	CEBPB_HUMAN	CCAAT/enhancer binding protein beta	15	Required for Lys-174 sumoylation.				acute-phase response|immune response		sequence-specific enhancer binding RNA polymerase II transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(9;5.72e-08)|STAD - Stomach adenocarcinoma(23;0.19)			CTCCCCCTGCCGCCGCCGCCG	0.647													T	48807614	T	T	48807614	3	4	227	1	0	0	0	0	1	0	0	0	3200	652	23	2	46	2	CEBPB	20	48807614	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08		48807614	14217906	77	15977											
HIRA	7290	broad.mit.edu	37	chr22	19365576	19365576	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggatgctgttaaagaatgCcgtggagaagtccctgtcat	14	7	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chr22:19365576C>T	uc002zpf.1	-	14	1649	c.1429G>A	c.(1429-1431)GCA>ACA	p.A477T	HIRA_uc011agx.1_Missense_Mutation_p.A343T|HIRA_uc010grn.1_Missense_Mutation_p.A477T|HIRA_uc010gro.1_Missense_Mutation_p.A433T|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	477	Interaction with CCNA1.|Interaction with ASF1A.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					TTAAAGAATGCCGTGGAGAAG	0.468													T	19365576	T	T	19365576	3	4	227	1	0	0	0	0	1	0	0	0	7120	739	26	3	1672	3	HIRA	22	19365576	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08		19365576	31938990	78	15978											
DDX3X	1654	broad.mit.edu	37	chrX	41204796	41204796	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tctgcttgacctcctaaatgCaacaggtaacattatgaatt	6	9	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chrX:41204796C>A	uc004dfe.2	+	12	2165	c.1310C>A	c.(1309-1311)GCA>GAA	p.A437E	DDX3X_uc004dff.2_Missense_Mutation_p.A437E|DDX3X_uc011mkq.1_Missense_Mutation_p.A421E|DDX3X_uc011mkr.1_Intron|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	437	Helicase C-terminal.|Necessary for interaction with XPO1.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						CTCCTAAATGCAACAGGTAAC	0.249										HNSCC(61;0.18)			A	41204796	A	A	41204796	3	1	227	1	0	0	0	0	1	0	0	0	4358	710	25	5	1356	5	DDX3X	23	41204796	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08		41204796	114065764	79	15979											
AKAP4	8852	broad.mit.edu	37	chrX	49957173	49957173	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgaaattgggcttatttgCcgaggctgcttgttcttcca	10	10	1	1			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chrX:49957173C>T	uc004dow.1	-	5	2315	c.2191G>A	c.(2191-2193)GCA>ACA	p.A731T	AKAP4_uc004dov.1_Missense_Mutation_p.A348T|AKAP4_uc010njp.1_Missense_Mutation_p.A553T|AKAP4_uc004dou.1_Missense_Mutation_p.A722T	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	731					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					GGCTTATTTGCCGAGGCTGCT	0.448													T	49957173	T	T	49957173	3	4	227	1	0	0	0	0	1	0	0	0	453	739	26	3	381	3	AKAP4	23	49957173	Missense_Mutation	SNP	C	TCGA-32-1991-01A-01D-1353-08	8752377	49957173	105313387	80	15980											
RGAG1	57529	broad.mit.edu	37	chrX	109694254	109694254	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtccacttcagagtatgggGtaatgtccccagggatgatg	13	8	1	2			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chrX:109694254G>A	uc004eor.1	+	3	655	c.409G>A	c.(409-411)GTA>ATA	p.V137I	RGAG1_uc011msr.1_Missense_Mutation_p.V137I	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	137										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						AGAGTATGGGGTAATGTCCCC	0.502													A	109694254	A	A	109694254	3	1	227	1	0	0	0	0	1	0	0	0	13274	1261	44	3	411	3	RGAG1	23	109694254	Missense_Mutation	SNP	G	TCGA-32-1991-01A-01D-1353-08	59737081	109694254	45576306	81	15981											
MAGEA11	4110	broad.mit.edu	37	chrX	148794878	148794878	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccctgccagcatcaagaggaAgaagaagagggaggactcag	14	9	2	4			TCGA-32-1991-01A-01D-1353-08	TCGA-32-1991-10C-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	4221fc24-897f-493b-ba37-34bf90986d7c	8191e3a5-eb2a-4912-a644-f942db086777	g.chrX:148794878A>C	uc004fdq.2	+	2	161	c.59A>C	c.(58-60)AAG>ACG	p.K20T	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Intron	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	20						cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					ATCAAGAGGAAGAAGAAGAGG	0.572													C	148794878	C	C	148794878	3	2	227	1	0	0	0	0	1	0	0	0	9165	72	3	5	74	5	MAGEA11	23	148794878	Missense_Mutation	SNP	A	TCGA-32-1991-01A-01D-1353-08	39100624	148794878	6475682	82	15982											
CCDC27	148870	broad.mit.edu	37	chr1	3684010	3684010	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagagctcccagtccaggGtatgcccagcccttcctcct	10	16	0	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:3684010G>A	uc001akv.2	+	10	1824	c.1743_splice	c.e10+1	p.R581_splice		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27											skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CCAGTCCAGGGTATGCCCAGC	0.647													A	3684010	A	A	3684010	5	1	228	1	0	0	0	0	0	0	1	0	2801	1275	44	3	1782	3	CCDC27	1	3684010	Splice_Site	SNP	G	TCGA-32-2491-01A-01D-1353-08		3684010	245566611	1	15983											
CASZ1	54897	broad.mit.edu	37	chr1	10702922	10702922	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcctgccgctcacctgccgCggtgctctcgttacccacgg	11	18	2	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:10702922C>T	uc001aro.2	-	20	4476	c.4156G>A	c.(4156-4158)GCG>ACG	p.A1386T		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TCACCTGCCGCGGTGCTCTCG	0.687													T	10702922	T	T	10702922	3	4	228	1	0	0	0	0	1	0	0	0	2685	768	27	1	1131	1	CASZ1	1	10702922	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	7018912	10702922	238547699	2	15984											
HSPG2	3339	broad.mit.edu	37	chr1	22170742	22170742	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atccagggtctgcccttctgCcactcgggaggaggagggct	15	12	2	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:22170742C>G	uc001bfj.2	-	65	8555	c.8515G>C	c.(8515-8517)GCA>CCA	p.A2839P	HSPG2_uc009vqd.2_Missense_Mutation_p.A2840P	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2839	Ig-like C2-type 14.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGCCCTTCTGCCACTCGGGAG	0.682													G	22170742	G	G	22170742	3	3	228	1	0	0	0	0	1	0	0	0	7430	739	26	5	4792	5	HSPG2	1	22170742	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	11467820	22170742	227079879	3	15985											
GRIK3	2899	broad.mit.edu	37	chr1	37282846	37282846	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagatgccaccaatgatgcGtgtggacagggctttgggca	14	10	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:37282846G>A	uc001caz.2	-	13	2041	c.1906C>T	c.(1906-1908)CGC>TGC	p.R636C	GRIK3_uc001cba.1_Missense_Mutation_p.R636C	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	636	Cytoplasmic (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CCAATGATGCGTGTGGACAGG	0.547													A	37282846	A	A	37282846	3	1	228	1	0	0	0	0	1	0	0	0	6775	1145	40	1	869	1	GRIK3	1	37282846	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	15112104	37282846	211967775	4	15986											
PIK3R3	8503	broad.mit.edu	37	chr1	46509434	46509434	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgaaccaaggatgtctgctGgtaatggagcactagctcct	11	10	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:46509434G>T	uc001cpb.3	-	10	2053	c.1297C>A	c.(1297-1299)CAG>AAG	p.Q433K	PIK3R3_uc009vyb.2_Missense_Mutation_p.Q374K|PIK3R3_uc009vyc.2_Missense_Mutation_p.Q450K|PIK3R3_uc001cpc.3_Missense_Mutation_p.Q433K|PIK3R3_uc010olw.1_Missense_Mutation_p.Q479K|PIK3R3_uc010olv.1_Missense_Mutation_p.Q223K	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	433	SH2 2.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					GATGTCTGCTGGTAATGGAGC	0.532													T	46509434	T	T	46509434	3	4	228	1	0	0	0	0	1	0	0	0	11920	1357	47	5	92	5	PIK3R3	1	46509434	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	9226588	46509434	202741187	5	15987											
PARS2	25973	broad.mit.edu	37	chr1	55224003	55224003	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgtctccatgttggctgagaAgctgcagcggggacagatgg	16	8	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:55224003A>T	uc001cxy.2	-	2	915	c.832T>A	c.(832-834)TTC>ATC	p.F278I		NM_152268	NP_689481	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase (mitochondrial)(putative)	278					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			ovary(2)	2					L-Proline(DB00172)	TTGGCTGAGAAGCTGCAGCGG	0.562													T	55224003	T	T	55224003	3	4	228	1	0	0	0	0	1	0	0	0	11467	72	3	5	599	5	PARS2	1	55224003	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	8714569	55224003	194026618	6	15988											
LRRIQ3	127255	broad.mit.edu	37	chr1	74507037	74507037	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtagtcctctggtcaaaagAgtgcgctcattatttaagtt	9	7	3	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:74507037A>G	uc001dfy.3	-	7	1770	c.1578T>C	c.(1576-1578)ACT>ACC	p.T526T	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	526										ovary(2)	2						TGGTCAAAAGAGTGCGCTCAT	0.358													G	74507037	G	G	74507037	2	3	228	1	0	0	0	0	0	0	0	1	9030	291	11	4		4	LRRIQ3	1	74507037	Silent	SNP	A	TCGA-32-2491-01A-01D-1353-08	19283034	74507037	174743584	7	15989											
SF3B4	10262	broad.mit.edu	37	chr1	149898406	149898406	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgccagaagtcgttcggctgCtgagccatggcgctcaccct	12	14	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:149898406C>G	uc001etj.1	-	3	619	c.568G>C	c.(568-570)GCA>CCA	p.A190P	SF3B4_uc001eti.1_5'Flank|SF3B4_uc001etk.1_Missense_Mutation_p.A190P|SF3B4_uc009wll.1_Missense_Mutation_p.A190P	NM_005850	NP_005841	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4	190						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CGTTCGGCTGCTGAGCCATGG	0.562													G	149898406	G	G	149898406	3	3	228	1	0	0	0	0	1	0	0	0	14153	797	28	5	722	5	SF3B4	1	149898406	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	75391369	149898406	99352215	8	15990											
FMO3	2328	broad.mit.edu	37	chr1	171079944	171079944	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttggtgttttttaaggtcatGatcagttccagaagtggctc	11	6	2	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:171079944G>A	uc001ghi.2	+	6	744	c.633G>A	c.(631-633)ATG>ATA	p.M211I	FMO3_uc001ghh.2_Missense_Mutation_p.M211I|FMO3_uc010pmb.1_Missense_Mutation_p.M191I|FMO3_uc010pmc.1_Missense_Mutation_p.M148I	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	211					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTAAGGTCATGATCAGTTCCA	0.338													A	171079944	A	A	171079944	3	1	228	1	0	0	0	0	1	0	0	0	5956	1290	45	3	651	3	FMO3	1	171079944	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	21181538	171079944	78170677	9	15991											
ABL2	27	broad.mit.edu	37	chr1	179086548	179086548	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aataggaaatttggctccagCatgagcagtataagtgtctc	10	7	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:179086548C>T	uc001gmj.3	-	8	1614	c.1327G>A	c.(1327-1329)GCT>ACT	p.A443T	ABL2_uc010pnf.1_Missense_Mutation_p.A443T|ABL2_uc010png.1_Missense_Mutation_p.A422T|ABL2_uc010pnh.1_Missense_Mutation_p.A422T|ABL2_uc009wxe.2_Missense_Mutation_p.A422T|ABL2_uc001gmg.3_Missense_Mutation_p.A428T|ABL2_uc001gmi.3_Missense_Mutation_p.A428T|ABL2_uc001gmh.3_Missense_Mutation_p.A407T|ABL2_uc010pne.1_Missense_Mutation_p.A407T|ABL2_uc009wxf.1_Missense_Mutation_p.A428T|ABL2_uc001gmk.2_Missense_Mutation_p.A407T	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	443	Protein kinase.|Kinase activation loop (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TTGGCTCCAGCATGAGCAGTA	0.443			T	ETV6	AML								T	179086548	T	T	179086548	3	4	228	1	0	0	0	0	1	0	0	0	93	710	25	3	2286	3	ABL2	1	179086548	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	8006604	179086548	70164073	10	15992											
PTPRC	5788	broad.mit.edu	37	chr1	198685877	198685877	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaaaatttaaaaccttataCgaaatatgttttatcattac	3	6	1	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:198685877C>T	uc001gur.1	+	13	1532	c.1352C>T	c.(1351-1353)ACG>ATG	p.T451M	PTPRC_uc001gus.1_Missense_Mutation_p.T403M|PTPRC_uc001gut.1_Missense_Mutation_p.T290M|PTPRC_uc009wzf.1_Missense_Mutation_p.T339M|PTPRC_uc010ppg.1_Missense_Mutation_p.T387M	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	451	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						AAACCTTATACGAAATATGTT	0.313													T	198685877	T	T	198685877	3	4	228	1	0	0	0	0	1	0	0	0	12797	536	19	1	1409	1	PTPRC	1	198685877	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	19599329	198685877	50564744	11	15993											
OPTC	26254	broad.mit.edu	37	chr1	203466194	203466194	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ccctcgtcaaaccccacgatGaccagacctactacagcagg	7	17	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:203466194G>C	uc001gzu.1	+	3	437	c.321G>C	c.(319-321)ATG>ATC	p.M107I		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	107	Ser/Thr-rich.					proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			ACCCCACGATGACCAGACCTA	0.562													C	203466194	C	C	203466194	3	2	228	1	0	0	0	0	1	0	0	0	10888	1290	45	5	327	5	OPTC	1	203466194	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	4780317	203466194	45784427	12	15994											
OBSCN	84033	broad.mit.edu	37	chr1	228404990	228404990	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttccggctccgcgtctctgGtgagcacgctgtgtgtgcat	13	13	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:228404990G>T	uc009xez.1	+	8	2697	c.2653_splice	c.e8+1	p.E885_splice	OBSCN_uc001hsn.2_Splice_Site_p.E885_splice	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CGCGTCTCTGGTGAGCACGCT	0.652													T	228404990	T	T	228404990	5	4	228	1	0	0	0	0	0	0	1	0	10812	1275	44	5	2680	5	OBSCN	1	228404990	Splice_Site	SNP	G	TCGA-32-2491-01A-01D-1353-08	24938796	228404990	20845631	13	15995											
CHML	1122	broad.mit.edu	37	chr1	241797601	241797601	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaacataattctgtgacccGtacagcacaagctcctggct	8	12	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr1:241797601G>A	uc001hzd.2	-	1	1632	c.1468C>T	c.(1468-1470)CGG>TGG	p.R490W	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	490					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TCTGTGACCCGTACAGCACAA	0.418													A	241797601	A	A	241797601	3	1	228	1	0	0	0	0	1	0	0	0	3351	1144	40	1	506	1	CHML	1	241797601	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	13392611	241797601	7453020	14	15996											
GDF7	151449	broad.mit.edu	37	chr2	20870425	20870425	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacgcctgctgtactcgcGggcagctgagcccctagtcg	13	16	0	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:20870425G>A	uc002rdz.1	+	2	1169	c.593G>A	c.(592-594)CGG>CAG	p.R198Q		NM_182828	NP_878248	Q7Z4P5	GDF7_HUMAN	growth differentiation factor 7 preproprotein	198					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGTACTCGCGGGCAGCTGAG	0.731													A	20870425	A	A	20870425	3	1	228	1	0	0	0	0	1	0	0	0	6318	1116	39	2	599	2	GDF7	2	20870425	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08		20870425	222328948	15	15997											
CAPN13	92291	broad.mit.edu	37	chr2	30986009	30986009	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcccattctccatcgcctgtGctgtatctgttggcttcaag	9	13	3	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:30986009G>C	uc002rnn.2	-	7	889	c.713C>G	c.(712-714)GCA>GGA	p.A238G	CAPN13_uc002rnp.1_Missense_Mutation_p.A238G	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	238	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					CATCGCCTGTGCTGTATCTGT	0.522													C	30986009	C	C	30986009	3	2	228	1	0	0	0	0	1	0	0	0	2626	1319	46	5	1360	5	CAPN13	2	30986009	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	10115584	30986009	212213364	16	15998											
EHBP1	23301	broad.mit.edu	37	chr2	63086375	63086375	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ccgtgaattcaaatccatttGatgatcctgatgctgcagaa	8	9	1	5			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:63086375G>C	uc002sby.2	+	9	1293	c.811G>C	c.(811-813)GAT>CAT	p.D271H	EHBP1_uc010fcp.2_Missense_Mutation_p.D236H|EHBP1_uc002sbx.2_Missense_Mutation_p.D236H|EHBP1_uc002sbz.2_Missense_Mutation_p.D236H|EHBP1_uc002scb.2_Missense_Mutation_p.D236H	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	271						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			AAATCCATTTGATGATCCTGA	0.358									Hereditary_Prostate_Cancer				C	63086375	C	C	63086375	3	2	228	1	0	0	0	0	1	0	0	0	4975	1290	45	5	841	5	EHBP1	2	63086375	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	32100366	63086375	180112998	17	15999											
SMYD5	10322	broad.mit.edu	37	chr2	73449902	73449902	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccaactggaacttctgcGgagactcttcacagaggccc	12	13	3	2	rs116053390	by1000genomes	TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:73449902G>A	uc002siw.2	+	7	691	c.662G>A	c.(661-663)CGG>CAG	p.R221Q	SMYD5_uc010yre.1_Missense_Mutation_p.R105Q|SMYD5_uc002six.1_RNA	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	221							metal ion binding				0						GAACTTCTGCGGAGACTCTTC	0.592													A	73449902	A	A	73449902	3	1	228	1	0	0	0	0	1	0	0	0	14825	1116	39	2	688	2	SMYD5	2	73449902	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	10363527	73449902	169749471	18	16000											
SEMA4F	10505	broad.mit.edu	37	chr2	74907015	74907016	+	Frame_Shift_Ins	INS	-	G	G													cagtgggggcgggactggctINSggcttcttcttggggattct							TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:74907015_74907016insG	uc002sna.1	+	14	2103_2104	c.1992_1993insG	c.(1990-1995)GCTGGCfs	p.A664fs	SEMA4F_uc010ffr.1_Frame_Shift_Ins_p.A276fs|SEMA4F_uc002snb.1_Frame_Shift_Ins_p.A276fs|SEMA4F_uc002snc.1_Frame_Shift_Ins_p.A509fs	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	664_665	Helical; (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CGGGACTGGCTGGCTTCTTCTT	0.619													G	74907016	G	G	74907015	7	5	228	1	0	1	1	0	0	0	0	0	14035	1567	55	0	2046	0	SEMA4F	2	74907015	Frame_Shift_Ins	INS	-	TCGA-32-2491-01A-01D-1353-08	1457113	74907015	168292358	19	16001											
CLASP1	23332	broad.mit.edu	37	chr2	122220134	122220134	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacaggtacatcatcaaatgCtttaataaaatcctcttcat	3	9	4	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:122220134C>T	uc002tnc.2	-	10	1303	c.913G>A	c.(913-915)GCA>ACA	p.A305T	CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.A305T|CLASP1_uc010yza.1_Missense_Mutation_p.A305T|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tng.1_Missense_Mutation_p.A305T	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	305					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					TCATCAAATGCTTTAATAAAA	0.328													T	122220134	T	T	122220134	3	4	228	1	0	0	0	0	1	0	0	0	3454	797	28	3	3879	3	CLASP1	2	122220134	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	47313119	122220134	120979239	20	16002											
MYO3B	140469	broad.mit.edu	37	chr2	171358331	171358331	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctcggaggaaatttaagaAaataagcaacagaaggaatg	11	4	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:171358331A>G	uc002ufy.2	+	28	3469	c.3326A>G	c.(3325-3327)AAA>AGA	p.K1109R	MYO3B_uc002ufv.2_Missense_Mutation_p.K1096R|MYO3B_uc010fqb.1_Missense_Mutation_p.K1096R|MYO3B_uc002ufz.2_Intron|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_Intron|MYO3B_uc002ugb.2_Intron	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	1109	IQ 2.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						AAATTTAAGAAAATAAGCAAC	0.348													G	171358331	G	G	171358331	3	3	228	1	0	0	0	0	1	0	0	0	10077	14	1	4	3436	4	MYO3B	2	171358331	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	49138197	171358331	71841042	21	16003											
DFNB59	494513	broad.mit.edu	37	chr2	179325759	179325759	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cacagctttacttggatgatCttttttctgactactatgac	6	9	2	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:179325759C>A	uc002umi.3	+	7	1173	c.817C>A	c.(817-819)CTT>ATT	p.L273I	DFNB59_uc002umj.3_Missense_Mutation_p.L273I	NM_001042702	NP_001036167	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	273					sensory perception of sound						0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			CTTGGATGATCTTTTTTCTGA	0.348													A	179325759	A	A	179325759	3	1	228	1	0	0	0	0	1	0	0	0	4456	913	32	5	839	5	DFNB59	2	179325759	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	7967428	179325759	63873614	22	16004											
TTN	7273	broad.mit.edu	37	chr2	179423224	179423224	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cactgcacatttaacccagtTtttctgtcctttttctagtg	5	11	2	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:179423224T>A	uc010zfg.1	-	276	79482	c.79258A>T	c.(79258-79260)AAC>TAC	p.N26420Y	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N20115Y|TTN_uc010zfi.1_Missense_Mutation_p.N20048Y|TTN_uc010zfj.1_Missense_Mutation_p.N19923Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27347							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAACCCAGTTTTTCTGTCCT	0.438													A	179423224	A	A	179423224	3	1	228	1	0	0	0	0	1	0	0	0	16732	1841	64	5	21161	5	TTN	2	179423224	Missense_Mutation	SNP	T	TCGA-32-2491-01A-01D-1353-08	97465	179423224	63776149	23	16005											
TTN	7273	broad.mit.edu	37	chr2	179424446	179424446	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ggtcagtgatgtacgagagtCtgtggtatcaacataagctc	12	7	3	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:179424446C>A	uc010zfg.1	-	275	78933	c.78709G>T	c.(78709-78711)GAC>TAC	p.D26237Y	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D19932Y|TTN_uc010zfi.1_Missense_Mutation_p.D19865Y|TTN_uc010zfj.1_Missense_Mutation_p.D19740Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27164							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTACGAGAGTCTGTGGTATCA	0.433													A	179424446	A	A	179424446	3	1	228	1	0	0	0	0	1	0	0	0	16732	913	32	5	21714	5	TTN	2	179424446	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	1222	179424446	63774927	24	16006											
SGPP2	130367	broad.mit.edu	37	chr2	223339305	223339305	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcttatgtacagaagtacGtcgtgaagaattatttctac	9	6	1	3	rs147179845		TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:223339305G>A	uc010zlo.1	+	2	238	c.238G>A	c.(238-240)GTC>ATC	p.V80I	SGPP2_uc010zlp.1_5'UTR	NM_152386	NP_689599	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphotase 2	80					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|skin(1)	2		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		ACAGAAGTACGTCGTGAAGAA	0.363													A	223339305	A	A	223339305	3	1	228	1	0	0	0	0	1	0	0	0	14220	1145	40	1	244	1	SGPP2	2	223339305	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	43914859	223339305	19860068	25	16007											
SP140	11262	broad.mit.edu	37	chr2	231106159	231106159	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccaaatgaataatgtaaaCgatttagaagatagacccag	7	7	0	4			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:231106159C>T	uc002vql.2	+	4	562	c.447C>T	c.(445-447)AAC>AAT	p.N149N	SP140_uc010zma.1_RNA|SP140_uc002vqk.2_Silent_p.N149N|SP140_uc002vqn.2_Silent_p.N149N|SP140_uc002vqm.2_Silent_p.N149N|SP140_uc010fxl.2_Silent_p.N149N	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	149					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		ATAATGTAAACGATTTAGAAG	0.373													T	231106159	T	T	231106159	2	4	228	1	0	0	0	0	0	0	0	1	14962	535	19	1		1	SP140	2	231106159	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08	7766854	231106159	12093214	26	16008											
RBM44	375316	broad.mit.edu	37	chr2	238726827	238726827	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatcgcagtcagagataatcAggcaatagaagataatacgt	10	6	2	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr2:238726827A>G	uc002vxi.3	+	3	1400	c.1268A>G	c.(1267-1269)CAG>CGG	p.Q423R		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	422							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AGAGATAATCAGGCAATAGAA	0.368													G	238726827	G	G	238726827	3	3	228	1	0	0	0	0	1	0	0	0	13138	188	7	4	1274	4	RBM44	2	238726827	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	7620668	238726827	4472546	27	16009											
ZFYVE20	64145	broad.mit.edu	37	chr3	15115967	15115967	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgaggctctctgctgggctcCagctgaaaagggccgatttc	13	12	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:15115967C>A	uc003bzm.1	-	14	2291	c.1677G>T	c.(1675-1677)CTG>CTT	p.L559L	ZFYVE20_uc010hek.1_Silent_p.L559L	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	559	Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						TGCTGGGCTCCAGCTGAAAAG	0.572													A	15115967	A	A	15115967	2	1	228	1	0	0	0	0	0	0	0	1	17663	581	21	5		5	ZFYVE20	3	15115967	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08		15115967	182906463	28	16010											
DHX30	22907	broad.mit.edu	37	chr3	47888187	47888187	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactgtgggtatcctgctgcGtaagctgcagagcaacccca	11	13	0	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:47888187G>A	uc003cru.2	+	11	2051	c.1625G>A	c.(1624-1626)CGT>CAT	p.R542H	DHX30_uc003crt.2_Missense_Mutation_p.R503H|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	542	Helicase ATP-binding.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		ATCCTGCTGCGTAAGCTGCAG	0.627													A	47888187	A	A	47888187	3	1	228	1	0	0	0	0	1	0	0	0	4504	1145	40	1	1670	1	DHX30	3	47888187	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	32772220	47888187	150134243	29	16011											
MST1	4485	broad.mit.edu	37	chr3	49724639	49724639	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacagcagggtctgttgtgtAgcaccaaggacctccggggt	14	11	1	0	rs41291704		TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:49724639A>G	uc003cxg.2	-	5	622	c.550T>C	c.(550-552)TAC>CAC	p.Y184H	MST1_uc011bcs.1_Missense_Mutation_p.Y184H|MST1_uc010hkx.2_Missense_Mutation_p.Y105H|MST1_uc011bct.1_Missense_Mutation_p.Y184H|MST1_uc011bcu.1_RNA|RNF123_uc003cxh.2_5'Flank	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	170	Kringle 1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCTGTTGTGTAGCACCAAGGA	0.627													G	49724639	G	G	49724639	3	3	228	1	0	0	0	0	1	0	0	0	9890	420	15	4	1683	4	MST1	3	49724639	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	1836452	49724639	148297791	30	16012											
NEK4	6787	broad.mit.edu	37	chr3	52778291	52778291	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcctgtgactgctttagtcGcctcctctctctggctgata	8	13	2	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:52778291G>A	uc003dfq.3	-	11	2047	c.1858C>T	c.(1858-1860)CGA>TGA	p.R620*	NEK4_uc011bej.1_Nonsense_Mutation_p.R531*|NEK4_uc003dfr.2_Nonsense_Mutation_p.R574*	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	620					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TGCTTTAGTCGCCTCCTCTCT	0.413													A	52778291	A	A	52778291	4	1	228	1	0	0	0	0	0	1	0	0	10326	1095	38	1	691	1	NEK4	3	52778291	Nonsense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	3053652	52778291	145244139	31	16013											
ACOX2	8309	broad.mit.edu	37	chr3	58510285	58510285	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagagagagatctctgtggcGtggagccaggggacatctga	17	7	2	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:58510285G>A	uc003dkl.2	-	11	1569	c.1394C>T	c.(1393-1395)ACG>ATG	p.T465M		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	465					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TCTCTGTGGCGTGGAGCCAGG	0.617													A	58510285	A	A	58510285	3	1	228	1	0	0	0	0	1	0	0	0	159	1145	40	1	671	1	ACOX2	3	58510285	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	5731994	58510285	139512145	32	16014											
C3orf67	200844	broad.mit.edu	37	chr3	58853638	58853638	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggttcttgagggggatgcGgatgcataatatgtagattg	15	3	1	2	rs141916956	byFrequency	TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:58853638G>A	uc003dkt.1	-	10	1074	c.665C>T	c.(664-666)CCG>CTG	p.P222L	C3orf67_uc003dks.1_Missense_Mutation_p.P37L|uc003dku.1_Intron|C3orf67_uc003dkv.1_Missense_Mutation_p.P37L|C3orf67_uc003dkw.2_Intron	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	222											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		AGGGGGATGCGGATGCATAAT	0.388													A	58853638	A	A	58853638	3	1	228	1	0	0	0	0	1	0	0	0	2241	1116	39	2	1054	2	C3orf67	3	58853638	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	343353	58853638	139168792	33	16015											
ZXDC	79364	broad.mit.edu	37	chr3	126160628	126160628	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgcaccagctggacctggaCgccctgcgccccgcactgca	11	19	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:126160628C>G	uc003eiv.2	-	8	2428	c.2374G>C	c.(2374-2376)GTC>CTC	p.V792L	ZXDC_uc010hsh.2_RNA	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	792	Interaction with CIITA.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		TGGACCTGGACGCCCTGCGCC	0.677													G	126160628	G	G	126160628	3	3	228	1	0	0	0	0	1	0	0	0	18249	536	19	5	214	5	ZXDC	3	126160628	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	67306990	126160628	71861802	34	16016											
TRIM42	287015	broad.mit.edu	37	chr3	140397352	140397352	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgctactactatgagagccGctgctgccgcaataccatca	8	14	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:140397352G>A	uc003eto.1	+	1	472	c.281G>A	c.(280-282)CGC>CAC	p.R94H		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	94	Cys-rich.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						TATGAGAGCCGCTGCTGCCGC	0.557													A	140397352	A	A	140397352	3	1	228	1	0	0	0	0	1	0	0	0	16514	1087	38	1	283	1	TRIM42	3	140397352	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	14236724	140397352	57625078	35	16017											
CP	1356	broad.mit.edu	37	chr3	148901264	148901264	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttaacatacctagaattcccAgatgttcttcttcagctttt	4	10	3	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:148901264A>T	uc003ewy.3	-	13	2667	c.2414T>A	c.(2413-2415)CTG>CAG	p.L805Q	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Missense_Mutation_p.L586Q|CP_uc003ewz.2_Missense_Mutation_p.L805Q	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	805	Plastocyanin-like 5.|F5/8 type A 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TAGAATTCCCAGATGTTCTTC	0.398													T	148901264	T	T	148901264	3	4	228	1	0	0	0	0	1	0	0	0	3787	188	7	5	811	5	CP	3	148901264	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	8503912	148901264	49121166	36	16018											
PIK3CA	5290	broad.mit.edu	37	chr3	178952072	178952072	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggagtatttcatgaaacaaAtgaatgatgcacatcatggt	9	5	2	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr3:178952072A>G	uc003fjk.2	+	21	3284	c.3127A>G	c.(3127-3129)ATG>GTG	p.M1043V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1043	PI3K/PI4K.		M -> I (in cancer; shows an increase in lipid kinase activity).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.M1043I(31)|p.M1043V(15)|p.M1043T(3)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CATGAAACAAATGAATGATGC	0.368		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			G	178952072	G	G	178952072	3	3	228	1	0	0	0	0	1	0	0	0	11913	101	4	4	3205	4	PIK3CA	3	178952072	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	30050808	178952072	19070358	37	16019											
DRD5	1816	broad.mit.edu	37	chr4	9784905	9784905	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacatgatgcccaacgccGttacccccggcaaccgggag	10	17	0	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr4:9784905G>A	uc003gmb.3	+	1	1648	c.1252G>A	c.(1252-1254)GTT>ATT	p.V418I		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	418	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GCCCAACGCCGTTACCCCCGG	0.557													A	9784905	A	A	9784905	3	1	228	1	0	0	0	0	1	0	0	0	4760	1145	40	1	1254	1	DRD5	4	9784905	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08		9784905	181369371	38	16020											
KLB	152831	broad.mit.edu	37	chr4	39408665	39408665	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tataggaatacaatgtccaaCgggggattgcaaagatctgt	11	6	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr4:39408665C>A	uc003gua.2	+	1	193	c.96C>A	c.(94-96)AAC>AAA	p.N32K	KLB_uc011byj.1_Missense_Mutation_p.N32K	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	32	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						CAATGTCCAACGGGGGATTGC	0.453													A	39408665	A	A	39408665	3	1	228	1	0	0	0	0	1	0	0	0	8332	535	19	5	98	5	KLB	4	39408665	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	29623760	39408665	151745611	39	16021											
FRAS1	80144	broad.mit.edu	37	chr4	79173649	79173649	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	accgctgtcatgtggacaccAggagctggcattcatccctg	11	13	2	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr4:79173649A>G	uc003hlb.2	+	5	853	c.413A>G	c.(412-414)CAG>CGG	p.Q138R	FRAS1_uc003hkw.2_Missense_Mutation_p.Q138R|FRAS1_uc003hky.1_5'UTR|FRAS1_uc003hkz.2_5'Flank	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	138	VWFC 2.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGTGGACACCAGGAGCTGGCA	0.562													G	79173649	G	G	79173649	3	3	228	1	0	0	0	0	1	0	0	0	6042	188	7	4	431	4	FRAS1	4	79173649	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	39764984	79173649	111980627	40	16022											
CENPE	1062	broad.mit.edu	37	chr4	104117134	104117134	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtataactcccaaatgatcTtctgaacccatcatggtata	6	10	3	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr4:104117134T>C	uc003hxb.1	-	4	390	c.300A>G	c.(298-300)GAA>GAG	p.E100E	CENPE_uc003hxc.1_Silent_p.E100E	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	100	Kinesin-motor.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CCAAATGATCTTCTGAACCCA	0.348													C	104117134	C	C	104117134	2	2	228	1	0	0	0	0	0	0	0	1	3230	1606	56	4		4	CENPE	4	104117134	Silent	SNP	T	TCGA-32-2491-01A-01D-1353-08	24943485	104117134	87037142	41	16023											
PRSS12	8492	broad.mit.edu	37	chr4	119239641	119239641	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagctcattcccagtgcagcGtacttcatccaacataactg	6	13	2	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr4:119239641G>A	uc003ica.1	-	5	1089	c.1042C>T	c.(1042-1044)CGC>TGC	p.R348C		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	348	SRCR 2.					membrane	scavenger receptor activity			skin(1)	1						CCAGTGCAGCGTACTTCATCC	0.478													A	119239641	A	A	119239641	3	1	228	1	0	0	0	0	1	0	0	0	12615	1145	40	1	1621	1	PRSS12	4	119239641	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	15122507	119239641	71914635	42	16024											
TLL1	7092	broad.mit.edu	37	chr4	166910622	166910622	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accttacgcagaacccctttGgaaaccttggacataccaca	6	14	0	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr4:166910622G>A	uc003irh.1	+	2	906	c.259G>A	c.(259-261)GGA>AGA	p.G87R	TLL1_uc011cjn.1_Missense_Mutation_p.G87R|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	87					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GAACCCCTTTGGAAACCTTGG	0.333													A	166910622	A	A	166910622	3	1	228	1	0	0	0	0	1	0	0	0	15942	1349	47	3	265	3	TLL1	4	166910622	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	47670981	166910622	24243654	43	16025											
ENPP6	133121	broad.mit.edu	37	chr4	185018423	185018423	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccgaaggccaggaagatgccCcgcatgtccatgagctcgtt	12	13	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr4:185018423C>G	uc003iwc.2	-	7	1234	c.1092G>C	c.(1090-1092)CGG>CGC	p.R364R		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	364	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GGAAGATGCCCCGCATGTCCA	0.587													G	185018423	G	G	185018423	2	3	228	1	0	0	0	0	0	0	0	1	5134	610	22	5		5	ENPP6	4	185018423	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08	18107801	185018423	6135853	44	16026											
PRDM9	56979	broad.mit.edu	37	chr5	23527861	23527861	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacacaggggagaagccctaCgtctgcagggaggatgagta	15	9	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr5:23527861C>T	uc003jgo.2	+	11	2846	c.2664C>T	c.(2662-2664)TAC>TAT	p.Y888Y		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	888					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGAAGCCCTACGTCTGCAGGG	0.527										HNSCC(3;0.000094)			T	23527861	T	T	23527861	2	4	228	1	0	0	0	0	0	0	0	1	12463	547	19	1		1	PRDM9	5	23527861	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08		23527861	157387399	45	16027											
FAM170A	340069	broad.mit.edu	37	chr5	118970068	118970068	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctgccaggctcacccaccGttgaggacacacccagagcc	10	18	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr5:118970068G>A	uc003ksm.2	+	3	835	c.625G>A	c.(625-627)GTT>ATT	p.V209I	FAM170A_uc003ksl.2_Intron|FAM170A_uc003ksn.2_Missense_Mutation_p.V209I|FAM170A_uc003kso.2_Missense_Mutation_p.V162I	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	209						intracellular	zinc ion binding			skin(1)	1						CTCACCCACCGTTGAGGACAC	0.587													A	118970068	A	A	118970068	3	1	228	1	0	0	0	0	1	0	0	0	5489	1145	40	1	635	1	FAM170A	5	118970068	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	95442207	118970068	61945192	46	16028											
PCDHA7	56141	broad.mit.edu	37	chr5	140215694	140215694	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggtgggtggcactggtggcGcagtgagagagcttgtgccg	21	7	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr5:140215694G>A	uc003lhq.2	+	1	1726	c.1726G>A	c.(1726-1728)GCA>ACA	p.A576T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A576T	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	576	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTGGTGGCGCAGTGAGAGA	0.662													A	140215694	A	A	140215694	3	1	228	1	0	0	0	0	1	0	0	0	11529	1087	38	1	1728	1	PCDHA7	5	140215694	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	21245626	140215694	40699566	47	16029											
PCDHA8	56140	broad.mit.edu	37	chr5	140221979	140221979	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actgacttccttatccttgcCtgtacgtgaagacgctcaat	7	12	1	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr5:140221979C>G	uc003lhs.2	+	1	1073	c.1073C>G	c.(1072-1074)CCT>CGT	p.P358R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.P358R	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	358	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTATCCTTGCCTGTACGTGAA	0.502													G	140221979	G	G	140221979	3	3	228	1	0	0	0	0	1	0	0	0	11530	681	24	5	1075	5	PCDHA8	5	140221979	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	6285	140221979	40693281	48	16030											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720522	140720522	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgccactgtcacgctcaccGtggccgtggccgacaggatc	12	17	2	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr5:140720522G>A	uc003ljk.1	+	1	2169	c.1984G>A	c.(1984-1986)GTG>ATG	p.V662M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.V662M	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	662	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGCTCACCGTGGCCGTGGC	0.682													A	140720522	A	A	140720522	3	1	228	1	0	0	0	0	1	0	0	0	11554	1145	40	1	1986	1	PCDHGA2	5	140720522	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	498543	140720522	40194738	49	16031											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720558	140720558	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggatccccgacatcctggccGacctgggcagcctcgagccc	12	18	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr5:140720558G>A	uc003ljk.1	+	1	2205	c.2020G>A	c.(2020-2022)GAC>AAC	p.D674N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.D674N	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	674	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCCTGGCCGACCTGGGCAG	0.687													A	140720558	A	A	140720558	3	1	228	1	0	0	0	0	1	0	0	0	11554	1058	37	2	2022	2	PCDHGA2	5	140720558	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	36	140720558	40194702	50	16032											
TBC1D9B	23061	broad.mit.edu	37	chr5	179318430	179318430	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcctccttgctggcgaaGcagatgtagttgttggagat	12	9	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr5:179318430G>A	uc003mlh.2	-	6	1030	c.993C>T	c.(991-993)TGC>TGT	p.C331C	TBC1D9B_uc003mli.2_Silent_p.C331C|TBC1D9B_uc003mlj.2_Silent_p.C331C	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	331	GRAM 2.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGCTGGCGAAGCAGATGTAGT	0.592													A	179318430	A	A	179318430	2	1	228	1	0	0	0	0	0	0	0	1	15625	963	34	3		3	TBC1D9B	5	179318430	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08	38597872	179318430	1596830	51	16033											
DSP	1832	broad.mit.edu	37	chr6	7582878	7582878	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcttcttcaattccaggcaTctaataggattcaggaatca	6	9	6	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr6:7582878T>C	uc003mxp.1	+	24	5662	c.5383T>C	c.(5383-5385)TCT>CCT	p.S1795P	DSP_uc003mxq.1_Missense_Mutation_p.S1196P	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1795	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ATTCCAGGCATCTAATAGGAT	0.353													C	7582878	C	C	7582878	3	2	228	1	0	0	0	0	1	0	0	0	4781	1435	50	4	5477	4	DSP	6	7582878	Missense_Mutation	SNP	T	TCGA-32-2491-01A-01D-1353-08		7582878	163532189	52	16034											
PHACTR1	221692	broad.mit.edu	37	chr6	13278556	13278556	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agatcaagaggaggctaaccCgaaaggtaggtggttctcca	13	8	2	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr6:13278556C>G	uc010jpc.2	+	12	1836	c.1504C>G	c.(1504-1506)CGA>GGA	p.R502G	PHACTR1_uc003nah.1_Missense_Mutation_p.R502G|TBC1D7_uc003naj.2_Intron|TBC1D7_uc011dis.1_Intron	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	502	RPEL 4.					cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GAGGCTAACCCGAAAGGTAGG	0.507													G	13278556	G	G	13278556	3	3	228	1	0	0	0	0	1	0	0	0	11809	644	23	5	1542	5	PHACTR1	6	13278556	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	5695678	13278556	157836511	53	16035											
BAT1	7919	broad.mit.edu	37	chr6	31508154	31508154	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gcccggagcaactctggcttGagcaggaagtcacgaaagcc	13	12	2	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr6:31508154G>C	uc003ntt.2	-	2	787	c.156C>G	c.(154-156)CTC>CTG	p.L52L	BAT1_uc003nts.2_Silent_p.L52L|BAT1_uc011dnn.1_Nonsense_Mutation_p.S48*|BAT1_uc003ntu.2_Silent_p.L52L|BAT1_uc003ntv.2_Silent_p.L52L|BAT1_uc003ntw.2_Silent_p.L52L|BAT1_uc003ntx.2_Silent_p.L52L|BAT1_uc011dno.1_Nonsense_Mutation_p.S48*|BAT1_uc011dnp.1_Nonsense_Mutation_p.S48*|BAT1_uc011dnq.1_RNA	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	52	Q motif.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						ACTCTGGCTTGAGCAGGAAGT	0.547													C	31508154	C	C	31508154	2	2	228	1	0	0	0	0	0	0	0	1	1318	1277	45	5		5	BAT1	6	31508154	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08	18229598	31508154	139606913	54	16036											
SKIV2L	6499	broad.mit.edu	37	chr6	31933760	31933760	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctctgcaagggccgagtgccCgagatggcagacctgcaccg	14	14	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr6:31933760C>A	uc003nyn.1	+	18	2561	c.2172C>A	c.(2170-2172)CCC>CCA	p.P724P	SKIV2L_uc011dou.1_Silent_p.P566P|SKIV2L_uc011dov.1_Silent_p.P531P	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	724	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GCCGAGTGCCCGAGATGGCAG	0.652													A	31933760	A	A	31933760	2	1	228	1	0	0	0	0	0	0	0	1	14359	639	23	5		5	SKIV2L	6	31933760	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08	425606	31933760	139181307	55	16037											
C6orf168	84553	broad.mit.edu	37	chr6	99729047	99729047	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtgaggctggacgtcacttgCactgttcgtggtctgtatag	14	8	2	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr6:99729047C>A	uc003ppj.3	-	6	1506	c.1223G>T	c.(1222-1224)TGC>TTC	p.C408F	C6orf168_uc003ppi.3_Missense_Mutation_p.C128F	NM_032511	NP_115900	Q5TGI0	CF168_HUMAN	hypothetical protein LOC84553	408										ovary(2)|central_nervous_system(1)	3		all_cancers(76;1.63e-06)|Acute lymphoblastic leukemia(125;5.12e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00898)|Colorectal(196;0.0699)|Lung NSC(302;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.073)		ACGTCACTTGCACTGTTCGTG	0.517													A	99729047	A	A	99729047	3	1	228	1	0	0	0	0	1	0	0	0	2343	710	25	5	10	5	C6orf168	6	99729047	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	67795287	99729047	71386020	56	16038											
BCLAF1	9774	broad.mit.edu	37	chr6	136597032	136597032	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttgagtttgacttcaggaCggtgagaatcactcgctatc	10	8	2	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr6:136597032C>T	uc003qgx.1	-	5	1884	c.1631G>A	c.(1630-1632)CGT>CAT	p.R544H	BCLAF1_uc003qgw.1_Missense_Mutation_p.R371H|BCLAF1_uc003qgy.1_Missense_Mutation_p.R542H|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R542H	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	544					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GACTTCAGGACGGTGAGAATC	0.433													T	136597032	T	T	136597032	3	4	228	1	0	0	0	0	1	0	0	0	1383	536	19	1	1167	1	BCLAF1	6	136597032	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	36867985	136597032	34518035	57	16039											
SYNE1	23345	broad.mit.edu	37	chr6	152685991	152685991	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttccctcaccttttacaaCgaatccctgcagacaaaagg	6	13	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr6:152685991C>T	uc010kiw.2	-	63	10738	c.10136G>A	c.(10135-10137)CGT>CAT	p.R3379H	SYNE1_uc003qot.3_Missense_Mutation_p.R3386H|SYNE1_uc003qou.3_Missense_Mutation_p.R3379H|SYNE1_uc010kja.1_Missense_Mutation_p.R84H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3379	Spectrin 7.|HAT 6.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTTTTACAACGAATCCCTGC	0.448										HNSCC(10;0.0054)			T	152685991	T	T	152685991	3	4	228	1	0	0	0	0	1	0	0	0	15442	536	19	1	16666	1	SYNE1	6	152685991	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	16088959	152685991	18429076	58	16040											
INMT	11185	broad.mit.edu	37	chr7	30795056	30795056	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcggccgatgggaggagaaGgaggagaagctgcgggcagc	21	7	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr7:30795056G>A	uc003tbs.1	+	3	397	c.381G>A	c.(379-381)AAG>AAA	p.K127K	FAM188B_uc010kwe.2_Intron|INMT_uc010kwc.1_RNA|INMT_uc010kwd.1_Silent_p.K126K	NM_006774	NP_006765	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	127						cytoplasm	amine N-methyltransferase activity				0						GGGAGGAGAAGGAGGAGAAGC	0.637													A	30795056	A	A	30795056	2	1	228	1	0	0	0	0	0	0	0	1	7745	991	35	3		3	INMT	7	30795056	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08		30795056	128343607	59	16041											
SEPT7	989	broad.mit.edu	37	chr7	35872442	35872442	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaaggctatgtgggatttgCcaatctcccaaatcaagtat	9	8	2	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr7:35872442C>T	uc010kxc.2	+	2	294	c.101C>T	c.(100-102)GCC>GTC	p.A34V	SEPT7_uc011kat.1_Missense_Mutation_p.A33V|SEPT7_uc011kau.1_Intron|SEPT7_uc011kav.1_5'UTR	NM_001788	NP_001779	Q16181	SEPT7_HUMAN	cell division cycle 10 isoform 1	34					cilium morphogenesis|cytokinesis|mitosis|protein heterooligomerization|regulation of embryonic cell shape	cilium axoneme|cleavage furrow|condensed chromosome kinetochore|midbody|nucleus|septin complex|spindle|stress fiber	GTP binding|protein binding|structural molecule activity				0						GTGGGATTTGCCAATCTCCCA	0.363													T	35872442	T	T	35872442	3	4	228	1	0	0	0	0	1	0	0	0	14069	739	26	3	105	3	SEPT7	7	35872442	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	5077386	35872442	123266221	60	16042											
COL1A2	1278	broad.mit.edu	37	chr7	94034005	94034005	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acattctttttttcttttagGgccctcaaggtttccaagga	7	9	3	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr7:94034005G>T	uc003ung.1	+	8	796	c.325G>T	c.(325-327)GGC>TGC	p.G109C	COL1A2_uc011kib.1_Missense_Mutation_p.G109C|COL1A2_uc010lfh.1_5'Flank	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	109					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTTCTTTTAGGGCCCTCAAGG	0.403										HNSCC(75;0.22)			T	94034005	T	T	94034005	3	4	228	1	0	0	0	0	1	0	0	0	3678	1246	43	5	355	5	COL1A2	7	94034005	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	58161563	94034005	65104658	61	16043											
MUC17	140453	broad.mit.edu	37	chr7	100675953	100675953	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacttcaacaattcctgttgActccaaaacttttgtgacca	4	12	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr7:100675953A>G	uc003uxp.1	+	3	1309	c.1256A>G	c.(1255-1257)GAC>GGC	p.D419G	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	419	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ATTCCTGTTGACTCCAAAACT	0.463													G	100675953	G	G	100675953	3	3	228	1	0	0	0	0	1	0	0	0	9974	275	10	4	1266	4	MUC17	7	100675953	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	6641948	100675953	58462710	62	16044											
MGAM	8972	broad.mit.edu	37	chr7	141736731	141736731	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctatacaccctcttcttcCgtgctcacagccgaggggac	8	16	3	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr7:141736731C>T	uc003vwy.2	+	18	2239	c.2185C>T	c.(2185-2187)CGT>TGT	p.R729C		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	729	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTCTTCTTCCGTGCTCACAG	0.493													T	141736731	T	T	141736731	3	4	228	1	0	0	0	0	1	0	0	0	9541	652	23	2	2251	2	MGAM	7	141736731	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	41060778	141736731	17401932	63	16045											
TRYX3	136541	broad.mit.edu	37	chr7	141954883	141954883	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttgaactcacagatatcaCacacattgtagctccaggta	6	11	3	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr7:141954883C>T	uc003vxb.2	-	3	748	c.428G>A	c.(427-429)TGT>TAT	p.C143Y	TRYX3_uc003vxc.3_Missense_Mutation_p.C143Y	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	143	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					ACAGATATCACACACATTGTA	0.433													T	141954883	T	T	141954883	3	4	228	1	0	0	0	0	1	0	0	0	16601	478	17	3	309	3	TRYX3	7	141954883	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	218152	141954883	17183780	64	16046											
ZNF282	8427	broad.mit.edu	37	chr7	148921339	148921339	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcatcatccaccaccgcaGccacaccaaggagcggccct	7	20	2	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr7:148921339G>A	uc003wfm.2	+	8	1721	c.1616G>A	c.(1615-1617)AGC>AAC	p.S539N	ZNF282_uc011kun.1_Splice_Site_p.P454_splice|ZNF282_uc003wfo.2_Missense_Mutation_p.A216T	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	539	C2H2-type 1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CACCACCGCAGCCACACCAAG	0.682													A	148921339	A	A	148921339	3	1	228	1	0	0	0	0	1	0	0	0	17816	971	34	3	1646	3	ZNF282	7	148921339	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	6966456	148921339	10217324	65	16047											
TEX15	56154	broad.mit.edu	37	chr8	30694497	30694497	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccatttgcttgtggctccccCgcaaaataagtaaaatattg	7	10	0	0	rs142941425		TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr8:30694497C>T	uc003xil.2	-	3	8154	c.8154G>A	c.(8152-8154)GCG>GCA	p.A2718A		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2718										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GTGGCTCCCCCGCAAAATAAG	0.423													T	30694497	T	T	30694497	2	4	228	1	0	0	0	0	0	0	0	1	15776	639	23	2		2	TEX15	8	30694497	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08		30694497	115669525	66	16048											
PXDNL	137902	broad.mit.edu	37	chr8	52387561	52387561	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attcctctactgttactgaaGcaactgcacgcccatggagt	8	12	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr8:52387561G>A	uc003xqu.3	-	7	766	c.665C>T	c.(664-666)GCT>GTT	p.A222V		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	222	LRRCT.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGTTACTGAAGCAACTGCACG	0.463													A	52387561	A	A	52387561	3	1	228	1	0	0	0	0	1	0	0	0	12848	971	34	3	3794	3	PXDNL	8	52387561	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	21693064	52387561	93976461	67	16049											
TSNARE1	203062	broad.mit.edu	37	chr8	143436006	143436006	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tactatcattacctaggggcTgacagccttgtctcgaaggt	10	10	2	1	rs117184426	byFrequency	TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr8:143436006T>C	uc003ywk.2	-	2	198	c.80A>G	c.(79-81)CAG>CGG	p.Q27R	TSNARE1_uc011lju.1_Missense_Mutation_p.Q27R|TSNARE1_uc003ywj.2_Missense_Mutation_p.Q27R|TSNARE1_uc003ywl.3_Missense_Mutation_p.Q27R	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	27					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					ACCTAGGGGCTGACAGCCTTG	0.602													C	143436006	C	C	143436006	3	2	228	1	0	0	0	0	1	0	0	0	16627	1580	55	4	1509	4	TSNARE1	8	143436006	Missense_Mutation	SNP	T	TCGA-32-2491-01A-01D-1353-08	91048445	143436006	2928016	68	16050											
SPATC1	375686	broad.mit.edu	37	chr8	145095019	145095019	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcagccccctcaccagcttcCtgaccagtcccattgcggga	9	18	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr8:145095019C>G	uc011lkw.1	+	2	523	c.421C>G	c.(421-423)CTG>GTG	p.L141V	SPATC1_uc011lkx.1_Missense_Mutation_p.L141V	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	141										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CACCAGCTTCCTGACCAGTCC	0.682													G	145095019	G	G	145095019	3	3	228	1	0	0	0	0	1	0	0	0	15016	680	24	5	427	5	SPATC1	8	145095019	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	1659013	145095019	1269003	69	16051											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18777020	18777020	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acggtggcccccttcggctaTctcaagatccaccgcctcaa	8	17	2	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr9:18777020T>C	uc003zne.3	+	19	2920	c.2793T>C	c.(2791-2793)TAT>TAC	p.Y931Y		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	931	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CCTTCGGCTATCTCAAGATCC	0.662													C	18777020	C	C	18777020	2	2	228	1	0	0	0	0	0	0	0	1	274	1442	50	4		4	ADAMTSL1	9	18777020	Silent	SNP	T	TCGA-32-2491-01A-01D-1353-08		18777020	122436411	70	16052											
NOL6	65083	broad.mit.edu	37	chr9	33467806	33467806	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagtccccaccattgtcctgCagctctggccagagcttcag	9	15	2	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr9:33467806C>T	uc003zsz.2	-	12	1586	c.1485G>A	c.(1483-1485)CTG>CTA	p.L495L	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Silent_p.L495L|NOL6_uc010mjv.2_Silent_p.L492L|NOL6_uc011lob.1_Silent_p.L443L|NOL6_uc003ztb.1_Silent_p.L495L	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	495					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CATTGTCCTGCAGCTCTGGCC	0.637													T	33467806	T	T	33467806	2	4	228	1	0	0	0	0	0	0	0	1	10525	697	25	3		3	NOL6	9	33467806	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08	14690786	33467806	107745625	71	16053											
C9orf139	401563	broad.mit.edu	37	chr9	139929144	139929144	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaggaggctgtcctgccaCgcctgcgggtgacccggcct	16	14	0	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr9:139929144C>T	uc004ckp.1	+	3	1725	c.211C>T	c.(211-213)CGC>TGC	p.R71C	FUT7_uc004ckq.2_5'Flank	NM_207511	NP_997394	Q6ZV77	CI139_HUMAN	hypothetical protein LOC401563	71											0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		TGTCCTGCCACGCCTGCGGGT	0.657													T	139929144	T	T	139929144	3	4	228	1	0	0	0	0	1	0	0	0	2459	536	19	1	217	1	C9orf139	9	139929144	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	106461338	139929144	1284287	72	16054											
IDI2	91734	broad.mit.edu	37	chr10	1065753	1065753	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtggtgatagattgtcatgaAcacaatgtcctctggagaaa	11	6	2	4			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr10:1065753A>T	uc001ifv.1	-	5	453	c.388T>A	c.(388-390)TTC>ATC	p.F130I	C10orf110_uc010qaf.1_5'Flank|C10orf110_uc001ifx.3_5'Flank|C10orf110_uc001ifw.3_5'Flank|C10orf110_uc001ify.3_5'Flank	NM_033261	NP_150286	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	130	Nudix hydrolase.				carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding				0		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		ATTGTCATGAACACAATGTCC	0.373													T	1065753	T	T	1065753	3	4	228	1	0	0	0	0	1	0	0	0	7500	43	2	5	299	5	IDI2	10	1065753	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08		1065753	134468994	73	16055											
SYT15	83849	broad.mit.edu	37	chr10	46962073	46962073	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctctctgccgcgggtgtacAtgtaggggcccaccaccact	12	15	1	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr10:46962073A>G	uc001jea.2	-	8	1316	c.1163T>C	c.(1162-1164)ATG>ACG	p.M388T	SYT15_uc001jdz.2_Intron|SYT15_uc001jeb.2_Missense_Mutation_p.M266T|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	388	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						GCGGGTGTACATGTAGGGGCC	0.672													G	46962073	G	G	46962073	3	3	228	1	0	0	0	0	1	0	0	0	15468	217	8	4	160	4	SYT15	10	46962073	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	45896320	46962073	88572674	74	16056											
JMJD1C	221037	broad.mit.edu	37	chr10	64950737	64950737	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttccagctgttgtagtcaGcaaatcccgtaaggttgagc	10	10	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr10:64950737G>A	uc001jmn.2	-	17	6508	c.6208C>T	c.(6208-6210)CTG>TTG	p.L2070L	JMJD1C_uc001jml.2_Silent_p.L1833L|JMJD1C_uc001jmm.2_Silent_p.L1782L|JMJD1C_uc010qiq.1_Silent_p.L1888L|JMJD1C_uc009xpi.2_Silent_p.L1888L|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmo.2_5'UTR	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	2070	LXXLL motif.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GTTGTAGTCAGCAAATCCCGT	0.463													A	64950737	A	A	64950737	2	1	228	1	0	0	0	0	0	0	0	1	7950	962	34	3		3	JMJD1C	10	64950737	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08	17988664	64950737	70584010	75	16057											
CALHM2	51063	broad.mit.edu	37	chr10	105207008	105207008	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cggctgtagagtgggaggccCtggttctcacggtacaagta	15	9	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr10:105207008C>G	uc001kwz.2	-	3	1259	c.873G>C	c.(871-873)CAG>CAC	p.Q291H	CALHM2_uc001kxa.2_Missense_Mutation_p.Q291H|CALHM2_uc001kxc.2_3'UTR|CALHM2_uc001kxb.2_Missense_Mutation_p.Q291H	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	291						integral to membrane				skin(1)	1						GTGGGAGGCCCTGGTTCTCAC	0.627													G	105207008	G	G	105207008	3	3	228	1	0	0	0	0	1	0	0	0	2583	680	24	5	102	5	CALHM2	10	105207008	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	40256271	105207008	30327739	76	16058											
MUC2	4583	broad.mit.edu	37	chr11	1093681	1093681	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cacccaccactggaagcacgGggccccccacccacacaagc	8	21	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr11:1093681G>C	uc001lsx.1	+	32	12601	c.12574G>C	c.(12574-12576)GGC>CGC	p.G4192R		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4192				GTQ -> TGS (in Ref. 4).		inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TGGAAGCACGGGGCCCCCCAC	0.617													C	1093681	C	C	1093681	3	2	228	1	0	0	0	0	1	0	0	0	9975	1246	43	5	5610	5	MUC2	11	1093681	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08		1093681	133912835	77	16059											
CHRNA10	57053	broad.mit.edu	37	chr11	3688949	3688949	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcacggcgccatcgtggcgCaggaccacgttggtgctggc	16	14	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr11:3688949C>T	uc001lyf.2	-	4	480	c.408G>A	c.(406-408)CTG>CTA	p.L136L	CHRNA10_uc010qxt.1_5'UTR|CHRNA10_uc010qxu.1_5'UTR	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	136	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	CATCGTGGCGCAGGACCACGT	0.731													T	3688949	T	T	3688949	2	4	228	1	0	0	0	0	0	0	0	1	3382	697	25	3		3	CHRNA10	11	3688949	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08	2595268	3688949	131317567	78	16060											
QSER1	79832	broad.mit.edu	37	chr11	32979551	32979551	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgagccaccaccaaagaaaCggaaaaaatggaaagaagaa	9	8	0	4			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr11:32979551C>T	uc001mty.2	+	8	4768	c.4501C>T	c.(4501-4503)CGG>TGG	p.R1501W	QSER1_uc001mtz.1_Missense_Mutation_p.R1262W|QSER1_uc001mua.2_Missense_Mutation_p.R1006W	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1501										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					ACCAAAGAAACGGAAAAAATG	0.413													T	32979551	T	T	32979551	3	4	228	1	0	0	0	0	1	0	0	0	12882	527	19	1	4523	1	QSER1	11	32979551	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	29290602	32979551	102026965	79	16061											
AGBL2	79841	broad.mit.edu	37	chr11	47726094	47726094	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actgtgagtaagtcatattaCcaatatgatggatgttttcc	8	6	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr11:47726094C>G	uc001ngg.2	-	6	686	c.586_splice	c.e6+1	p.E196_splice	AGBL2_uc010rhq.1_Splice_Site_p.E158_splice|AGBL2_uc001ngh.1_Splice_Site_p.E140_splice	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic						proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						AGTCATATTACCAATATGATG	0.318													G	47726094	G	G	47726094	5	3	228	1	0	0	0	0	0	0	1	0	376	521	18	5	2173	5	AGBL2	11	47726094	Splice_Site	SNP	C	TCGA-32-2491-01A-01D-1353-08	14746543	47726094	87280422	80	16062											
EML3	256364	broad.mit.edu	37	chr11	62378668	62378668	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agattgggtcccgctaggctCttcgctggccccctgagggg	15	13	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr11:62378668C>A	uc001ntu.1	-	3	651	c.343G>T	c.(343-345)GAG>TAG	p.E115*	EML3_uc001ntr.1_Nonsense_Mutation_p.E87*|EML3_uc001nts.1_Nonsense_Mutation_p.E87*|EML3_uc001ntt.1_Missense_Mutation_p.K11N|EML3_uc010rly.1_Nonsense_Mutation_p.E115*|EML3_uc009yny.1_5'UTR|ROM1_uc001ntv.2_5'Flank	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	115						cytoplasm|microtubule	protein binding			ovary(1)	1						CCGCTAGGCTCTTCGCTGGCC	0.697													A	62378668	A	A	62378668	4	1	228	1	0	0	0	0	0	1	0	0	5098	922	32	5	2427	5	EML3	11	62378668	Nonsense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	14652574	62378668	72627848	81	16063											
CCDC87	55231	broad.mit.edu	37	chr11	66358101	66358101	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccccttgaagatcactggctCgccaaagattaactctatct	6	13	3	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr11:66358101C>T	uc001oiq.3	-	1	2454	c.2386G>A	c.(2386-2388)GAG>AAG	p.E796K	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	796										ovary(1)|skin(1)	2						ATCACTGGCTCGCCAAAGATT	0.532													T	66358101	T	T	66358101	3	4	228	1	0	0	0	0	1	0	0	0	2862	893	31	2	167	2	CCDC87	11	66358101	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	3979433	66358101	68648415	82	16064											
FAT3	120114	broad.mit.edu	37	chr11	92535042	92535042	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctgggacagagacacatccGacgttaatcgccaagtgagc	11	12	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr11:92535042G>A	uc001pdj.3	+	9	8880	c.8863G>A	c.(8863-8865)GAC>AAC	p.D2955N		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2955	Cadherin 27.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGACACATCCGACGTTAATCG	0.522										TCGA Ovarian(4;0.039)			A	92535042	A	A	92535042	3	1	228	1	0	0	0	0	1	0	0	0	5691	1058	37	2	8897	2	FAT3	11	92535042	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	26176941	92535042	42471474	83	16065											
HEPHL1	341208	broad.mit.edu	37	chr11	93839268	93839268	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtggacatacataccatccAttatcatgctgagagctttc	7	10	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr11:93839268A>G	uc001pep.2	+	17	3174	c.3017A>G	c.(3016-3018)CAT>CGT	p.H1006R	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	1006	Extracellular (Potential).|Plastocyanin-like 6.	Copper 1; type 2 (By similarity).			copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CATACCATCCATTATCATGCT	0.353													G	93839268	G	G	93839268	3	3	228	1	0	0	0	0	1	0	0	0	7055	217	8	4	3083	4	HEPHL1	11	93839268	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	1304226	93839268	41167248	84	16066											
RNF26	79102	broad.mit.edu	37	chr11	119206267	119206267	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	attgccatgagcctggtggcTtatgtgatcaacagcctggt	12	9	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr11:119206267T>A	uc001pwh.2	+	1	1031	c.435T>A	c.(433-435)GCT>GCA	p.A145A		NM_032015	NP_114404	Q9BY78	RNF26_HUMAN	ring finger protein 26	145	Leu-rich.						zinc ion binding			ovary(1)	1		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)		GCCTGGTGGCTTATGTGATCA	0.592													A	119206267	A	A	119206267	2	1	228	1	0	0	0	0	0	0	0	1	13486	1596	56	5		5	RNF26	11	119206267	Silent	SNP	T	TCGA-32-2491-01A-01D-1353-08	25366999	119206267	15800249	85	16067											
KIAA0528	9847	broad.mit.edu	37	chr12	22602814	22602815	+	Frame_Shift_Del	DEL	AA	-	-													gcatcaccacttacatttatAagacactgtgcctataagaa							TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr12:22602814_22602815delAA	uc001rfq.2	-	25	3110_3111	c.2882_2883delTT	c.(2881-2883)CTTfs	p.L961fs	KIAA0528_uc010sir.1_Frame_Shift_Del_p.L817fs|KIAA0528_uc010sis.1_Frame_Shift_Del_p.L1012fs|KIAA0528_uc010sit.1_Frame_Shift_Del_p.L1014fs|KIAA0528_uc010siu.1_Frame_Shift_Del_p.L1012fs|KIAA0528_uc001rfr.2_Frame_Shift_Del_p.L1003fs	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	961							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TTACATTTATAAGACACTGTGC	0.411													-	22602815	-	-	22602814	7	5	228	1	0	1	0	1	0	0	0	0	8182	349	13	0	123	0	KIAA0528	12	22602814	Frame_Shift_Del	DEL	AA	TCGA-32-2491-01A-01D-1353-08		22602814	111249081	86	16068											
C12orf45	121053	broad.mit.edu	37	chr12	105380235	105380235	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgacggcgggaagcgaCggccgcggaggtgacggacg	20	11	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr12:105380235C>G	uc001tlb.2	+	1	138	c.105C>G	c.(103-105)GAC>GAG	p.D35E		NM_152318	NP_689531	Q8N5I9	CL045_HUMAN	hypothetical protein LOC121053	35											0						CGGGAAGCGACGGCCGCGGAG	0.706													G	105380235	G	G	105380235	3	3	228	1	0	0	0	0	1	0	0	0	1691	535	19	5	107	5	C12orf45	12	105380235	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	82777421	105380235	28471660	87	16069											
HVCN1	84329	broad.mit.edu	37	chr12	111099056	111099056	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccaggggcaggggcaacGtcaggggctgcagctctgcc	19	12	2	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr12:111099056G>A	uc001trs.1	-	4	384	c.219C>T	c.(217-219)GAC>GAT	p.D73D	HVCN1_uc001trq.1_Silent_p.D73D|HVCN1_uc001trt.1_Silent_p.D73D|HVCN1_uc010syd.1_Silent_p.D53D	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	73	Cytoplasmic (Potential).				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						CAGGGGCAACGTCAGGGGCTG	0.527													A	111099056	A	A	111099056	2	1	228	1	0	0	0	0	0	0	0	1	7462	1136	40	1		1	HVCN1	12	111099056	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08	5718821	111099056	22752839	88	16070											
RB1	5925	broad.mit.edu	37	chr13	48955550	48955550	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atttagaacgatgtgaacatCgaatcatggaatcccttgca	8	8	1	2	rs121913304		TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr13:48955550C>T	uc001vcb.2	+	17	1832	c.1666C>T	c.(1666-1668)CGA>TGA	p.R556*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	556	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.R556*(5)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATGTGAACATCGAATCATGGA	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	48955550	T	T	48955550	4	4	228	1	0	0	0	0	0	1	0	0	13098	876	31	2	1732	2	RB1	13	48955550	Nonsense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08		48955550	66214328	89	16071											
OLFM4	10562	broad.mit.edu	37	chr13	53624151	53624151	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acatcagcaaaccgtctgtgGttcagctcaactggagaggg	12	10	4	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr13:53624151G>C	uc001vhl.2	+	5	778	c.778G>C	c.(778-780)GTT>CTT	p.V260L	OLFM4_uc001vhk.1_Intron	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	260	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		ACCGTCTGTGGTTCAGCTCAA	0.448													C	53624151	C	C	53624151	3	2	228	1	0	0	0	0	1	0	0	0	10855	1261	44	5	796	5	OLFM4	13	53624151	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	4668601	53624151	61545727	90	16072											
DCT	1638	broad.mit.edu	37	chr13	95121065	95121065	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatcataaacactgcagttgGcaaactgcggctgggttcca	10	10	1	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr13:95121065G>A	uc001vlv.3	-	2	957	c.530C>T	c.(529-531)GCC>GTC	p.A177V	DCT_uc010afh.2_Missense_Mutation_p.A177V	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	177	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		ACTGCAGTTGGCAAACTGCGG	0.458													A	95121065	A	A	95121065	3	1	228	1	0	0	0	0	1	0	0	0	4304	1203	42	3	1164	3	DCT	13	95121065	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	41496914	95121065	20048813	91	16073											
AKAP6	9472	broad.mit.edu	37	chr14	33014783	33014783	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacgacaaaggtggatgtgaGgaagacaatgcttctgcagt	14	6	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr14:33014783G>T	uc001wrq.2	+	4	1094	c.924G>T	c.(922-924)GAG>GAT	p.E308D	AKAP6_uc010aml.2_Missense_Mutation_p.E305D	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	308					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GTGGATGTGAGGAAGACAATG	0.488													T	33014783	T	T	33014783	3	4	228	1	0	0	0	0	1	0	0	0	455	991	35	5	934	5	AKAP6	14	33014783	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08		33014783	74334757	92	16074											
SERPINA6	866	broad.mit.edu	37	chr14	94776220	94776220	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccagctggcaggggagctccGagtcatgaaggtaactgatg	15	9	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr14:94776220G>A	uc001ycv.2	-	3	841	c.737C>T	c.(736-738)GCG>GTG	p.A246V	SERPINA6_uc010auv.2_RNA	NM_001756	NP_001747	P08185	CBG_HUMAN	corticosteroid binding globulin precursor	246					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			skin(3)|ovary(1)|central_nervous_system(1)	5		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	GGGGAGCTCCGAGTCATGAAG	0.542													A	94776220	A	A	94776220	3	1	228	1	0	0	0	0	1	0	0	0	14093	1059	37	2	492	2	SERPINA6	14	94776220	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	61761437	94776220	12573320	93	16075											
SERPINA9	327657	broad.mit.edu	37	chr14	94935885	94935885	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgtgtgaggttgaagcccAggccctggagaatctgggtc	16	8	1	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr14:94935885A>G	uc001ydf.2	-	2	508	c.347T>C	c.(346-348)CTG>CCG	p.L116P	SERPINA9_uc001yde.2_Intron|SERPINA9_uc010avc.2_Intron|SERPINA9_uc001ydg.2_Missense_Mutation_p.L80P|SERPINA9_uc001ydh.1_Missense_Mutation_p.L116P|SERPINA9_uc001ydi.1_Missense_Mutation_p.L80P	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	98					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GTTGAAGCCCAGGCCCTGGAG	0.567													G	94935885	G	G	94935885	3	3	228	1	0	0	0	0	1	0	0	0	14095	188	7	4	976	4	SERPINA9	14	94935885	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	159665	94935885	12413655	94	16076											
PCSK6	5046	broad.mit.edu	37	chr15	101933603	101933603	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccattcccagatgcccagacGaaaatggagcccaggccctg	10	15	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr15:101933603G>A	uc002bwy.2	-	9	1337	c.1023C>T	c.(1021-1023)TTC>TTT	p.F341F	PCSK6_uc010bpd.2_Silent_p.F211F|PCSK6_uc010bpe.2_Silent_p.F341F|PCSK6_uc002bxa.2_Silent_p.F341F|PCSK6_uc002bxb.2_Silent_p.F341F|PCSK6_uc002bxc.1_Silent_p.F341F|PCSK6_uc002bxd.1_Silent_p.F341F|PCSK6_uc002bxe.2_Silent_p.F341F|PCSK6_uc002bxg.1_Silent_p.F341F	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	341	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATGCCCAGACGAAAATGGAGC	0.627													A	101933603	A	A	101933603	2	1	228	1	0	0	0	0	0	0	0	1	11604	1049	37	2		2	PCSK6	15	101933603	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08		101933603	597789	95	16077											
ITGAD	3681	broad.mit.edu	37	chr16	31422196	31422196	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggccgaagtcacagggacGcaggttgggcgtgacaggag	18	8	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr16:31422196G>A	uc002ebv.1	+	12	1402	c.1353G>A	c.(1351-1353)ACG>ACA	p.T451T	ITGAD_uc010cap.1_Silent_p.T451T	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	451	Extracellular (Potential).|FG-GAP 5.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TCACAGGGACGCAGGTTGGGC	0.657													A	31422196	A	A	31422196	2	1	228	1	0	0	0	0	0	0	0	1	7884	1074	38	1		1	ITGAD	16	31422196	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08		31422196	58932557	96	16078											
COQ9	57017	broad.mit.edu	37	chr16	57492187	57492187	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atcctcatgctccctcacaaCatcccgtccagcctgagcct	5	19	2	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr16:57492187C>G	uc002elq.2	+	6	652	c.636C>G	c.(634-636)AAC>AAG	p.N212K	COQ9_uc002elr.2_Missense_Mutation_p.N177K|COQ9_uc002els.2_Missense_Mutation_p.N5K	NM_020312	NP_064708	O75208	COQ9_HUMAN	coenzyme Q9 homolog precursor	212					ubiquinone biosynthetic process	mitochondrion				breast(1)	1						TCCCTCACAACATCCCGTCCA	0.562													G	57492187	G	G	57492187	3	3	228	1	0	0	0	0	1	0	0	0	3751	477	17	5	658	5	COQ9	16	57492187	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	26069991	57492187	32862566	97	16079											
TP53	7157	broad.mit.edu	37	chr17	7577568	7577568	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgcccatgcaggaactgttaCacatgtagttgtagtggatg	12	8	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr17:7577568C>A	uc002gim.2	-	7	907	c.713G>T	c.(712-714)TGT>TTT	p.C238F	TP53_uc002gig.1_Missense_Mutation_p.C238F|TP53_uc002gih.2_Missense_Mutation_p.C238F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106F|TP53_uc010cng.1_Missense_Mutation_p.C106F|TP53_uc002gii.1_Missense_Mutation_p.C106F|TP53_uc010cnh.1_Missense_Mutation_p.C238F|TP53_uc010cni.1_Missense_Mutation_p.C238F|TP53_uc002gij.2_Missense_Mutation_p.C238F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145F|TP53_uc002gio.2_Missense_Mutation_p.C106F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577568	A	A	7577568	3	1	228	1	0	0	0	0	1	0	0	0	16378	478	17	5	577	5	TP53	17	7577568	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08		7577568	73617642	98	16080											
TP53	7157	broad.mit.edu	37	chr17	7578265	7578265	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcaaatttccttccactcggAtaagatgctgaggaggggcc	12	10	0	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr17:7578265A>T	uc002gim.2	-	6	778	c.584T>A	c.(583-585)ATC>AAC	p.I195N	TP53_uc002gig.1_Missense_Mutation_p.I195N|TP53_uc002gih.2_Missense_Mutation_p.I195N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.I63N|TP53_uc010cng.1_Missense_Mutation_p.I63N|TP53_uc002gii.1_Missense_Mutation_p.I63N|TP53_uc010cnh.1_Missense_Mutation_p.I195N|TP53_uc010cni.1_Missense_Mutation_p.I195N|TP53_uc002gij.2_Missense_Mutation_p.I195N|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.I102N|TP53_uc002gio.2_Missense_Mutation_p.I63N|TP53_uc010vug.1_Missense_Mutation_p.I156N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	195	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> F (in sporadic cancers; somatic mutation).|I -> L (in a sporadic cancer; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> T (in sporadic cancers; somatic mutation).|I -> V (in a sporadic cancer; somatic mutation).|I -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|I -> N (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.I195T(61)|p.I195F(16)|p.I195N(12)|p.0?(7)|p.I195S(4)|p.A189_V197delAPPQHLIRV(4)|p.I195fs*14(3)|p.I195fs*52(3)|p.K164_P219del(1)|p.I195L(1)|p.I195fs*50(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.I195fs*12(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCCACTCGGATAAGATGCTG	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578265	T	T	7578265	3	4	228	1	0	0	0	0	1	0	0	0	16378	333	12	5	710	5	TP53	17	7578265	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	697	7578265	73616945	99	16081											
RAI1	10743	broad.mit.edu	37	chr17	17697820	17697820	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaggccgactacctgagcGgctccgaggacccactggag	15	13	0	1	rs147708297		TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr17:17697820G>A	uc002grm.2	+	3	2027	c.1558G>A	c.(1558-1560)GGC>AGC	p.G520S	RAI1_uc002grn.1_Missense_Mutation_p.G520S	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	520						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CTACCTGAGCGGCTCCGAGGA	0.687													A	17697820	A	A	17697820	3	1	228	1	0	0	0	0	1	0	0	0	13007	1116	39	2	1560	2	RAI1	17	17697820	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	10119555	17697820	63497390	100	16082											
SLC13A2	9058	broad.mit.edu	37	chr17	26818573	26818573	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtgtgctactccgccagcatCgggggcatcgccacgctgac	13	15	0	1	rs146824818		TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr17:26818573C>T	uc002hbh.2	+	5	760	c.693C>T	c.(691-693)ATC>ATT	p.I231I	SLC13A2_uc010wal.1_Silent_p.I188I|SLC13A2_uc010wam.1_Silent_p.I187I|SLC13A2_uc010wan.1_Silent_p.I280I|SLC13A2_uc010wao.1_Silent_p.I188I|SLC13A2_uc002hbi.2_Silent_p.I160I	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	231	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CCGCCAGCATCGGGGGCATCG	0.632													T	26818573	T	T	26818573	2	4	228	1	0	0	0	0	0	0	0	1	14392	874	31	2		2	SLC13A2	17	26818573	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08	9120753	26818573	54376637	101	16083											
VAT1	10493	broad.mit.edu	37	chr17	41168349	41168349	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgaagggccagactgagtcaAtgtggggcttgatgtggccc	16	9	1	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr17:41168349A>G	uc002icm.1	-	5	1193	c.1073T>C	c.(1072-1074)ATT>ACT	p.I358T	VAT1_uc010cyw.1_Missense_Mutation_p.I224T|VAT1_uc010whk.1_Missense_Mutation_p.I290T	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	358						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		GACTGAGTCAATGTGGGGCTT	0.607													G	41168349	G	G	41168349	3	3	228	1	0	0	0	0	1	0	0	0	17126	101	4	4	116	4	VAT1	17	41168349	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	14349776	41168349	40026861	102	16084											
GRIN2C	2905	broad.mit.edu	37	chr17	72851132	72851132	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctgagctgctaaacaccaCagccaccgtcatgccctgct	7	18	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr17:72851132C>T	uc002jlt.1	-	2	256	c.100G>A	c.(100-102)GTG>ATG	p.V34M	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.V34M|GRIN2C_uc002jlv.1_Missense_Mutation_p.V34M	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	34	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CTAAACACCACAGCCACCGTC	0.706													T	72851132	T	T	72851132	3	4	228	1	0	0	0	0	1	0	0	0	6781	478	17	3	3649	3	GRIN2C	17	72851132	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	31682783	72851132	8344078	103	16085											
ADAMTS10	81794	broad.mit.edu	37	chr19	8661249	8661249	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggccaatgtcctcattgaCgctgcagcttctctcgcgct	9	15	2	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:8661249C>T	uc002mkj.1	-	10	1406	c.1132G>A	c.(1132-1134)GTC>ATC	p.V378I	ADAMTS10_uc002mkk.1_Missense_Mutation_p.V10I	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	378	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TCCTCATTGACGCTGCAGCTT	0.662													T	8661249	T	T	8661249	3	4	228	1	0	0	0	0	1	0	0	0	256	536	19	1	2247	1	ADAMTS10	19	8661249	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08		8661249	50467734	104	16086											
MUC16	94025	broad.mit.edu	37	chr19	9050207	9050207	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtcttcagagctgtggtgGtggtctccattctttttgtc	12	8	4	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:9050207G>A	uc002mkp.2	-	5	31628	c.31424C>T	c.(31423-31425)ACC>ATC	p.T10475I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10477	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCTGTGGTGGTGGTCTCCAT	0.483													A	9050207	A	A	9050207	3	1	228	1	0	0	0	0	1	0	0	0	9973	1261	44	3	12419	3	MUC16	19	9050207	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	388958	9050207	50078776	105	16087											
RAVER1	125950	broad.mit.edu	37	chr19	10434234	10434234	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagctgcccatcctggccGcacgccagctgccggaggaa	12	16	1	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:10434234G>A	uc002moa.2	-	4	896	c.816C>T	c.(814-816)TGC>TGT	p.C272C		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	255	RRM 3.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CATCCTGGCCGCACGCCAGCT	0.667													A	10434234	A	A	10434234	2	1	228	1	0	0	0	0	0	0	0	1	13094	1079	38	1		1	RAVER1	19	10434234	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08	1384027	10434234	48694749	106	16088											
CYP4F8	11283	broad.mit.edu	37	chr19	15739191	15739191	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcccccaatccctacattcGcccgcggctgcacccaggac	7	20	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:15739191G>A	uc002nbi.2	+	12	1259	c.1195G>A	c.(1195-1197)GCC>ACC	p.A399T	CYP4F8_uc010xoj.1_Missense_Mutation_p.A211T	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	399					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CCCTACATTCGCCCGCGGCTG	0.637													A	15739191	A	A	15739191	3	1	228	1	0	0	0	0	1	0	0	0	4191	1087	38	1	1228	1	CYP4F8	19	15739191	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	5304957	15739191	43389792	107	16089											
OR10H1	26539	broad.mit.edu	37	chr19	15918727	15918727	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggccatgatgagcaggttgcCcagcagcgtgaacaggtaca	14	10	0	3			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:15918727C>A	uc002nbq.2	-	1	210	c.121G>T	c.(121-123)GGC>TGC	p.G41C		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCAGGTTGCCCAGCAGCGTG	0.597													A	15918727	A	A	15918727	3	1	228	1	0	0	0	0	1	0	0	0	10905	623	22	5	839	5	OR10H1	19	15918727	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	179536	15918727	43210256	108	16090											
EPS15L1	58513	broad.mit.edu	37	chr19	16515514	16515514	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catcctgtttctgagcctcgAgctcctgcaaactgcttgtt	8	13	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:16515514A>G	uc002ndz.1	-	14	1319	c.1313T>C	c.(1312-1314)CTC>CCC	p.L438P	EPS15L1_uc002ndx.2_Missense_Mutation_p.L438P|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.L328P|EPS15L1_uc010xpf.1_Missense_Mutation_p.L341P|EPS15L1_uc002nea.1_Missense_Mutation_p.L438P|EPS15L1_uc010eah.1_Missense_Mutation_p.L438P|EPS15L1_uc002neb.1_Missense_Mutation_p.L284P|EPS15L1_uc002nec.1_Missense_Mutation_p.L438P	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	438					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						CTGAGCCTCGAGCTCCTGCAA	0.542													G	16515514	G	G	16515514	3	3	228	1	0	0	0	0	1	0	0	0	5193	304	11	4	1321	4	EPS15L1	19	16515514	Missense_Mutation	SNP	A	TCGA-32-2491-01A-01D-1353-08	596787	16515514	42613469	109	16091											
PRX	57716	broad.mit.edu	37	chr19	40901148	40901148	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcagccacccctggcactagTtctgctgcctcagtgtcccg	9	17	3	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:40901148T>C	uc002onr.2	-	7	3380	c.3111A>G	c.(3109-3111)GAA>GAG	p.E1037E	PRX_uc002onq.2_Silent_p.E898E|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1037					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGGCACTAGTTCTGCTGCCT	0.627													C	40901148	C	C	40901148	2	2	228	1	0	0	0	0	0	0	0	1	12642	1722	60	4		4	PRX	19	40901148	Silent	SNP	T	TCGA-32-2491-01A-01D-1353-08	24385634	40901148	18227835	110	16092											
C19orf54	284325	broad.mit.edu	37	chr19	41248416	41248416	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accccacccacgggcaccacGtacacccggccgtcagtggc	10	20	1	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:41248416G>A	uc002oou.1	-	6	1098	c.978C>T	c.(976-978)TAC>TAT	p.Y326Y	C19orf54_uc002oow.1_Silent_p.Y154Y|C19orf54_uc002oox.1_Intron|C19orf54_uc002ooy.1_Intron|C19orf54_uc010xvs.1_Intron	NM_198476	NP_940878	Q5BKX5	CS054_HUMAN	hypothetical protein LOC284325	326											0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CGGGCACCACGTACACCCGGC	0.662													A	41248416	A	A	41248416	2	1	228	1	0	0	0	0	0	0	0	1	1936	1140	40	1		1	C19orf54	19	41248416	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08	347268	41248416	17880567	111	16093											
FOXA3	3171	broad.mit.edu	37	chr19	46375547	46375547	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctccgggtacggggcccCgggtcctgggctggtgcacg	18	14	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:46375547C>T	uc002pdr.2	+	2	481	c.284C>T	c.(283-285)CCG>CTG	p.P95L		NM_004497	NP_004488	P55318	FOXA3_HUMAN	forkhead box A3	95					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)	1		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		TACGGGGCCCCGGGTCCTGGG	0.682													T	46375547	T	T	46375547	3	4	228	1	0	0	0	0	1	0	0	0	5991	652	23	2	290	2	FOXA3	19	46375547	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	5127131	46375547	12753436	112	16094											
MYH14	79784	broad.mit.edu	37	chr19	50713834	50713834	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttcgaggcggcggcgctgcGggacgaaggcgaggaggagg	23	8	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:50713834G>A	uc002prr.1	+	2	259	c.212G>A	c.(211-213)CGG>CAG	p.R71Q	MYH14_uc010enu.1_Missense_Mutation_p.R71Q|MYH14_uc002prq.1_Missense_Mutation_p.R71Q	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	71	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GCGGCGCTGCGGGACGAAGGC	0.736													A	50713834	A	A	50713834	3	1	228	1	0	0	0	0	1	0	0	0	10033	1116	39	2	214	2	MYH14	19	50713834	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	4338287	50713834	8415149	113	16095											
ZNF347	84671	broad.mit.edu	37	chr19	53644386	53644386	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttacatttgtaaggtttttcTccagtatggatgacctgatg	9	6	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:53644386T>A	uc002qbb.1	-	5	1764	c.1695A>T	c.(1693-1695)GGA>GGT	p.G565G	ZNF347_uc010eql.1_Silent_p.G566G|ZNF347_uc002qbc.1_Silent_p.G566G	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		AAGGTTTTTCTCCAGTATGGA	0.408													A	53644386	A	A	53644386	2	1	228	1	0	0	0	0	0	0	0	1	17858	1538	54	5		5	ZNF347	19	53644386	Silent	SNP	T	TCGA-32-2491-01A-01D-1353-08	2930552	53644386	5484597	114	16096											
BIRC8	112401	broad.mit.edu	37	chr19	53793037	53793037	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caaggaataaaaacaacagcGatatgtctgtccatgcagat	8	8	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr19:53793037G>A	uc002qbk.2	-	1	1839	c.591C>T	c.(589-591)ATC>ATT	p.I197I		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	197	RING-type.				apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		AAACAACAGCGATATGTCTGT	0.443													A	53793037	A	A	53793037	2	1	228	1	0	0	0	0	0	0	0	1	1440	1048	37	2		2	BIRC8	19	53793037	Silent	SNP	G	TCGA-32-2491-01A-01D-1353-08	148651	53793037	5335946	115	16097											
C20orf118	140711	broad.mit.edu	37	chr20	35507541	35507541	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgcagagcctgtaccggcGgatggagggctgcagcgggc	18	12	0	1	rs147682253		TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr20:35507541G>A	uc002xgg.1	+	3	295	c.287G>A	c.(286-288)CGG>CAG	p.R96Q		NM_080628	NP_542195	A0PJX2	CT118_HUMAN	hypothetical protein LOC140711	96	TLD.										0		Myeloproliferative disorder(115;0.00874)				CTGTACCGGCGGATGGAGGGC	0.667													A	35507541	A	A	35507541	3	1	228	1	0	0	0	0	1	0	0	0	2084	1116	39	2	297	2	C20orf118	20	35507541	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08		35507541	27517979	116	16098											
NEURL2	140825	broad.mit.edu	37	chr20	44519558	44519558	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgtgcacccgatggaagcGggtgggagggggctccgggc	20	11	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr20:44519558G>A	uc002xqg.1	-	1	344	c.73C>T	c.(73-75)CGC>TGC	p.R25C	CTSA_uc002xqh.2_5'Flank|CTSA_uc002xqj.3_5'Flank|CTSA_uc002xqi.2_5'Flank|CTSA_uc010zxi.1_5'Flank|CTSA_uc002xqk.3_5'Flank	NM_080749	NP_542787	Q9BR09	NEUL2_HUMAN	neuralized-like protein 2	25	NHR.				intracellular signal transduction						0		Myeloproliferative disorder(115;0.0122)				CGATGGAAGCGGGTGGGAGGG	0.711													A	44519558	A	A	44519558	3	1	228	1	0	0	0	0	1	0	0	0	10346	1116	39	2	792	2	NEURL2	20	44519558	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	9012017	44519558	18505962	117	16099											
NFATC2	4773	broad.mit.edu	37	chr20	50140360	50140360	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggccaccccggccaggggCggctgctccaccaggaggcc	16	18	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr20:50140360C>T	uc002xwd.2	-	2	640	c.420G>A	c.(418-420)CCG>CCA	p.P140P	NFATC2_uc002xwc.2_Silent_p.P140P|NFATC2_uc010zyv.1_Intron|NFATC2_uc010zyw.1_Intron|NFATC2_uc010zyx.1_Silent_p.P120P|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Silent_p.P120P	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	140	Trans-activation domain A (TAD-A).				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					CGGCCAGGGGCGGCTGCTCCA	0.721													T	50140360	T	T	50140360	2	4	228	1	0	0	0	0	0	0	0	1	10362	755	27	1		1	NFATC2	20	50140360	Silent	SNP	C	TCGA-32-2491-01A-01D-1353-08	5620802	50140360	12885160	118	16100											
LAMA5	3911	broad.mit.edu	37	chr20	60912694	60912694	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcacacatgtgtcacaccGcagccccgtcacacggggcc	12	17	2	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr20:60912694G>A	uc002ycq.2	-	16	2183	c.2116C>T	c.(2116-2118)CGG>TGG	p.R706W		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	706	Laminin EGF-like 8.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGTCACACCGCAGCCCCGTC	0.667													A	60912694	A	A	60912694	3	1	228	1	0	0	0	0	1	0	0	0	8609	1086	38	1	9231	1	LAMA5	20	60912694	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	10772334	60912694	2112826	119	16101											
APP	351	broad.mit.edu	37	chr21	27369692	27369692	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacgtttaacaggatctcggGcaagaggttcctgggtagtc	13	8	1	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr21:27369692G>A	uc002ylz.2	-	8	1273	c.1073C>T	c.(1072-1074)GCC>GTC	p.A358V	APP_uc010glk.2_Intron|APP_uc002yma.2_Intron|APP_uc011ach.1_Missense_Mutation_p.A302V|APP_uc002ymb.2_Intron|APP_uc010glj.2_Intron|APP_uc011aci.1_Intron	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	358	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				AGGATCTCGGGCAAGAGGTTC	0.438													A	27369692	A	A	27369692	3	1	228	1	0	0	0	0	1	0	0	0	815	1203	42	3	1283	3	APP	21	27369692	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08		27369692	20760203	120	16102											
TOP3B	8940	broad.mit.edu	37	chr22	22317253	22317253	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgatgtactcatagagccgcCacgcgtcaccccctgcaaca	8	16	2	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr22:22317253C>A	uc002zvs.2	-	12	1652	c.1217G>T	c.(1216-1218)TGG>TTG	p.W406L	TOP3B_uc010gtm.1_5'UTR|TOP3B_uc002zvr.2_Missense_Mutation_p.W131L|TOP3B_uc010gtl.2_Missense_Mutation_p.W406L|TOP3B_uc002zvt.3_Missense_Mutation_p.W406L	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	406					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		ATAGAGCCGCCACGCGTCACC	0.617													A	22317253	A	A	22317253	3	1	228	1	0	0	0	0	1	0	0	0	16365	595	21	5	1399	5	TOP3B	22	22317253	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08		22317253	28987313	121	16103											
ADRBK2	157	broad.mit.edu	37	chr22	26086159	26086159	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attctctttctgtttagccaGcaaatattctcttggatgaa	6	8	3	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr22:26086159G>A	uc003abx.3	+	12	1108	c.961G>A	c.(961-963)GCA>ACA	p.A321T	ADRBK2_uc010gux.2_Missense_Mutation_p.A321T|ADRBK2_uc003abw.2_Missense_Mutation_p.A208T|ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	321	Protein kinase.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	TGTTTAGCCAGCAAATATTCT	0.398													A	26086159	A	A	26086159	3	1	228	1	0	0	0	0	1	0	0	0	344	971	34	3	1007	3	ADRBK2	22	26086159	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08	3768906	26086159	25218407	122	16104											
OSBP2	23762	broad.mit.edu	37	chr22	31137264	31137264	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggggccaggagctaccaccTcaaggccagctcagaggtgg	15	12	2	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr22:31137264T>G	uc003aiy.1	+	2	865	c.761T>G	c.(760-762)CTC>CGC	p.L254R	OSBP2_uc011ala.1_Missense_Mutation_p.L89R|OSBP2_uc010gwc.1_Missense_Mutation_p.L81R|OSBP2_uc003aix.1_Missense_Mutation_p.L254R|OSBP2_uc011alb.1_Missense_Mutation_p.L254R|OSBP2_uc003aiz.1_Missense_Mutation_p.L254R	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	254	PH.				lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						AGCTACCACCTCAAGGCCAGC	0.612													G	31137264	G	G	31137264	3	3	228	1	0	0	0	0	1	0	0	0	11274	1551	54	5	767	5	OSBP2	22	31137264	Missense_Mutation	SNP	T	TCGA-32-2491-01A-01D-1353-08	5051105	31137264	20167302	123	16105											
MORC2	22880	broad.mit.edu	37	chr22	31336801	31336801	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctccgcacgggtcttgaaaCggcttgacgtgtacttgtac	12	11	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chr22:31336801C>T	uc003aje.1	-	11	2026	c.662G>A	c.(661-663)CGT>CAT	p.R221H		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	283	Potential.						ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						GGTCTTGAAACGGCTTGACGT	0.567													T	31336801	T	T	31336801	3	4	228	1	0	0	0	0	1	0	0	0	9702	536	19	1	2318	1	MORC2	22	31336801	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	199537	31336801	19967765	124	16106											
DACH2	117154	broad.mit.edu	37	chrX	85403790	85403790	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ataaccacagcaacagtgccGgaggcggcggcaggggcaac	15	12	0	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chrX:85403790G>A	uc004eew.2	+	1	336	c.166G>A	c.(166-168)GGA>AGA	p.G56R	DACH2_uc004eex.2_Missense_Mutation_p.G56R|DACH2_uc010nmq.2_5'UTR	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	56	Poly-Gly.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						CAACAGTGCCGGAGGCGGCGG	0.567													A	85403790	A	A	85403790	3	1	228	1	0	0	0	0	1	0	0	0	4221	1117	39	2	168	2	DACH2	23	85403790	Missense_Mutation	SNP	G	TCGA-32-2491-01A-01D-1353-08		85403790	69866770	125	16107											
SRPX2	27286	broad.mit.edu	37	chrX	99925877	99925877	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agggtattgaccgagaccgcTacatggaacctgtcaccccc	10	14	1	2			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chrX:99925877T>C	uc004egb.2	+	11	1771	c.1291T>C	c.(1291-1293)TAC>CAC	p.Y431H		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	431					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						CCGAGACCGCTACATGGAACC	0.512											OREG0019890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	99925877	C	C	99925877	3	2	228	1	0	0	0	0	1	0	0	0	15164	1522	53	4	1329	4	SRPX2	23	99925877	Missense_Mutation	SNP	T	TCGA-32-2491-01A-01D-1353-08	14522087	99925877	55344683	126	16108											
GPRASP2	114928	broad.mit.edu	37	chrX	101972268	101972268	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gttagctaagcaactacaagCccaaatagacaaccaaaatg	6	10	0	1			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chrX:101972268C>G	uc004ejk.2	+	4	3805	c.2471C>G	c.(2470-2472)GCC>GGC	p.A824G	GPRASP2_uc004ejl.2_Missense_Mutation_p.A824G|GPRASP2_uc004ejm.2_Missense_Mutation_p.A824G|GPRASP2_uc011mrp.1_Missense_Mutation_p.A163G	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	824						cytoplasm	protein binding			ovary(1)	1						CAACTACAAGCCCAAATAGAC	0.403													G	101972268	G	G	101972268	3	3	228	1	0	0	0	0	1	0	0	0	6723	739	26	5	2473	5	GPRASP2	23	101972268	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	2046391	101972268	53298292	127	16109											
ZCCHC18	644353	broad.mit.edu	37	chrX	103359839	103359839	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agccaggaagcgaaaatacaCaacccgctgttcatattgtg	9	10	1	0			TCGA-32-2491-01A-01D-1353-08	TCGA-32-2491-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcca710c-959e-410c-b454-917da7af9bfb	54ecc5be-74ee-4d0c-a1bc-8c0749d8fe89	g.chrX:103359839C>G	uc011msh.1	+	3	2353	c.1037C>G	c.(1036-1038)ACA>AGA	p.T346R	MCART6_uc004elu.2_Intron|ZCCHC18_uc011msg.1_Intron	NM_001143978	NP_001137450	P0CG32	ZCC18_HUMAN	zinc finger, CCHC domain containing 18	346							nucleic acid binding|zinc ion binding				0						CGAAAATACACAACCCGCTGT	0.483													G	103359839	G	G	103359839	3	3	228	1	0	0	0	0	1	0	0	0	17583	478	17	5	1039	5	ZCCHC18	23	103359839	Missense_Mutation	SNP	C	TCGA-32-2491-01A-01D-1353-08	1387571	103359839	51910721	128	16110											
SPEN	23013	broad.mit.edu	37	chr1	16260498	16260498	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tttagaagaaaaaacagcacCtccagtgacaaacaactctg	6	10	1	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:16260498C>G	uc001axk.1	+	11	7967	c.7763C>G	c.(7762-7764)CCT>CGT	p.P2588R	SPEN_uc010obp.1_Missense_Mutation_p.P2547R	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2588	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AAAACAGCACCTCCAGTGACA	0.522													G	16260498	G	G	16260498	3	3	229	1	0	0	0	0	1	0	0	0	15037	681	24	5	7805	5	SPEN	1	16260498	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08		16260498	232990123	1	16111											
CLCNKB	1188	broad.mit.edu	37	chr1	16377403	16377403	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agcatctggactcgctgttcGacaaccactcctgggcgctg	11	14	1	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:16377403G>A	uc001axw.3	+	12	1167	c.1087G>A	c.(1087-1089)GAC>AAC	p.D363N	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.D363N|CLCNKB_uc001axy.3_Missense_Mutation_p.D194N	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	363					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CTCGCTGTTCGACAACCACTC	0.672													A	16377403	A	A	16377403	3	1	229	1	0	0	0	0	1	0	0	0	3470	1058	37	2	1277	2	CLCNKB	1	16377403	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	116905	16377403	232873218	2	16112											
LDLRAD2	401944	broad.mit.edu	37	chr1	22140914	22140914	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acctggcggaactgtgcgggCagacgtggcagggggacggg	21	9	0	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:22140914C>G	uc001bfg.1	+	2	296	c.109C>G	c.(109-111)CAG>GAG	p.Q37E		NM_001013693	NP_001013715	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain	37	Extracellular (Potential).					integral to membrane	receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		ACTGTGCGGGCAGACGTGGCA	0.448													G	22140914	G	G	22140914	3	3	229	1	0	0	0	0	1	0	0	0	8706	711	25	5	115	5	LDLRAD2	1	22140914	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	5763511	22140914	227109707	3	16113											
HSPG2	3339	broad.mit.edu	37	chr1	22165399	22165399	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagcggcctgagtcctcagGggctgcacgctcaaagtgca	14	12	2	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:22165399G>A	uc001bfj.2	-	74	10109	c.10069C>T	c.(10069-10071)CCT>TCT	p.P3357S	HSPG2_uc009vqd.2_Missense_Mutation_p.P3358S	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3357	Ig-like C2-type 19.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GAGTCCTCAGGGGCTGCACGC	0.682													A	22165399	A	A	22165399	3	1	229	1	0	0	0	0	1	0	0	0	7430	1232	43	3	3202	3	HSPG2	1	22165399	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	24485	22165399	227085222	4	16114											
ELAVL4	1996	broad.mit.edu	37	chr1	50610767	50610767	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagcaaaaccaacctcatcGtcaactatttaccccagaat	3	14	2	1	rs116391279	by1000genomes	TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:50610767G>A	uc001csb.2	+	2	416	c.148G>A	c.(148-150)GTC>ATC	p.V50I	ELAVL4_uc001cry.3_Missense_Mutation_p.V53I|ELAVL4_uc001crz.3_Missense_Mutation_p.V50I|ELAVL4_uc001csa.3_Missense_Mutation_p.V67I|ELAVL4_uc001csc.3_Missense_Mutation_p.V50I|ELAVL4_uc009vyu.2_Missense_Mutation_p.V55I|ELAVL4_uc010omz.1_Missense_Mutation_p.V55I	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	50	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						CAACCTCATCGTCAACTATTT	0.448													A	50610767	A	A	50610767	3	1	229	1	0	0	0	0	1	0	0	0	5052	1145	40	1	253	1	ELAVL4	1	50610767	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	28445368	50610767	198639854	5	16115											
DMRTB1	63948	broad.mit.edu	37	chr1	53925199	53925199	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcttcctggtgcccgtcaagGgacacgcgggcaaatgccgc	14	14	1	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:53925199G>T	uc001cvq.1	+	1	128	c.73G>T	c.(73-75)GGA>TGA	p.G25*		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	25	DM.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GCCCGTCAAGGGACACGCGGG	0.602													T	53925199	T	T	53925199	4	4	229	1	0	0	0	0	0	1	0	0	4590	1233	43	5	75	5	DMRTB1	1	53925199	Nonsense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	3314432	53925199	195325422	6	16116											
ARHGAP29	9411	broad.mit.edu	37	chr1	94650593	94650594	+	Frame_Shift_Ins	INS	-	T	T													tgactaaattttccaaacacINStttcgatgacaaacaaggag							TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:94650593_94650594insT	uc001dqj.3	-	18	2312_2313	c.1943_1944insA	c.(1942-1944)AAGfs	p.K648fs	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Frame_Shift_Ins_p.K214fs	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	648	Phorbol-ester/DAG-type.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTTCCAAACACTTTCGATGACA	0.361													T	94650594	T	T	94650593	7	5	229	1	0	1	1	0	0	0	0	0	878	564	20	0	1865	0	ARHGAP29	1	94650593	Frame_Shift_Ins	INS	-	TCGA-32-2494-01A-01D-1353-08	40725394	94650593	154600028	7	16117											
CD2	914	broad.mit.edu	37	chr1	117311354	117311354	+	Frame_Shift_Del	DEL	A	-	-													cccagacctcgagttcagccAaaacctccccatggggcagc							TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:117311354delA	uc001egu.3	+	5	1034	c.1005delA	c.(1003-1005)CCAfs	p.P335fs		NM_001767	NP_001758	P06729	CD2_HUMAN	CD2 molecule precursor	335	Cytoplasmic (Potential).|Pro-rich.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			breast(1)	1	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	GAGTTCAGCCAAAACCTCCCC	0.517													-	117311354	-	-	117311354	7	5	229	1	0	1	0	1	0	0	0	0	2979	117	5	0	1023	0	CD2	1	117311354	Frame_Shift_Del	DEL	A	TCGA-32-2494-01A-01D-1353-08	22660761	117311354	131939267	8	16118											
OR10R2	343406	broad.mit.edu	37	chr1	158450132	158450132	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctctgcattaccccactctTatgagctggcaggtgtgtgg	11	12	2	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:158450132T>C	uc010pik.1	+	1	465	c.465T>C	c.(463-465)CTT>CTC	p.L155L	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	155	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					ACCCCACTCTTATGAGCTGGC	0.473													C	158450132	C	C	158450132	2	2	229	1	0	0	0	0	0	0	0	1	10917	1741	61	4		4	OR10R2	1	158450132	Silent	SNP	T	TCGA-32-2494-01A-01D-1353-08	41138778	158450132	90800489	9	16119											
RCSD1	92241	broad.mit.edu	37	chr1	167667016	167667016	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggctgcagcccccagacCggccctgcccagctggagac	12	19	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:167667016C>T	uc001gem.2	+	6	1342	c.1155C>T	c.(1153-1155)ACC>ACT	p.T385T	RCSD1_uc010pli.1_Silent_p.T355T	NM_052862	NP_443094	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	385										ovary(2)|central_nervous_system(2)|skin(1)	5	all_hematologic(923;0.215)					GCCCCCAGACCGGCCCTGCCC	0.642													T	167667016	T	T	167667016	2	4	229	1	0	0	0	0	0	0	0	1	13185	639	23	2		2	RCSD1	1	167667016	Silent	SNP	C	TCGA-32-2494-01A-01D-1353-08	9216884	167667016	81583605	10	16120											
NME7	29922	broad.mit.edu	37	chr1	169138771	169138771	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattgctctgagagttccagGgcgtaaatgccgggcaattt	13	8	1	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:169138771G>A	uc001gfu.2	-	11	1250	c.1012C>T	c.(1012-1014)CCT>TCT	p.P338S	NME7_uc010plq.1_RNA|NME7_uc001gft.2_Missense_Mutation_p.P302S	NM_013330	NP_037462	Q9Y5B8	NDK7_HUMAN	nucleoside diphosphate kinase 7 isoform a	338					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)					AGAGTTCCAGGGCGTAAATGC	0.368													A	169138771	A	A	169138771	3	1	229	1	0	0	0	0	1	0	0	0	10496	1232	43	3	126	3	NME7	1	169138771	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	1471755	169138771	80111850	11	16121											
LAMC1	3915	broad.mit.edu	37	chr1	183111900	183111900	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttaccatctggctgcttcaAcaccccgtccattgaaaagc	6	15	2	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:183111900A>G	uc001gpy.3	+	28	5062	c.4805A>G	c.(4804-4806)AAC>AGC	p.N1602S		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	1602	Potential.|Domain II and I.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCTGCTTCAACACCCCGTCC	0.527													G	183111900	G	G	183111900	3	3	229	1	0	0	0	0	1	0	0	0	8614	43	2	4	4915	4	LAMC1	1	183111900	Missense_Mutation	SNP	A	TCGA-32-2494-01A-01D-1353-08	13973129	183111900	66138721	12	16122											
HMCN1	83872	broad.mit.edu	37	chr1	186107024	186107024	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	caggaccaggacttgcaataAtccatcagttcagcatggtg	10	10	2	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:186107024A>T	uc001grq.1	+	89	14073	c.13844A>T	c.(13843-13845)AAT>ATT	p.N4615I	HMCN1_uc001grs.1_Missense_Mutation_p.N184I	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4615	TSP type-1 2.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACTTGCAATAATCCATCAGTT	0.493													T	186107024	T	T	186107024	3	4	229	1	0	0	0	0	1	0	0	0	7220	101	4	5	14198	5	HMCN1	1	186107024	Missense_Mutation	SNP	A	TCGA-32-2494-01A-01D-1353-08	2995124	186107024	63143597	13	16123											
LGALS8	3964	broad.mit.edu	37	chr1	236711404	236711404	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agatttaaagagctcagcagTattgacacgctggaaattaa	9	6	1	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr1:236711404T>A	uc001hxz.1	+	11	1278	c.897T>A	c.(895-897)AGT>AGA	p.S299R	LGALS8_uc001hxw.1_Missense_Mutation_p.S341R|LGALS8_uc001hxy.1_Missense_Mutation_p.S341R|LGALS8_uc009xgg.1_RNA|LGALS8_uc001hya.1_Missense_Mutation_p.S299R|LGALS8_uc001hyb.1_Missense_Mutation_p.S299R|LGALS8_uc001hyc.1_Missense_Mutation_p.S282R	NM_201543	NP_963837	O00214	LEG8_HUMAN	galectin-8 isoform b	299	Galectin 2.					cytoplasm|extracellular space	sugar binding			ovary(1)	1	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.0253)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			AGCTCAGCAGTATTGACACGC	0.408													A	236711404	A	A	236711404	3	1	229	1	0	0	0	0	1	0	0	0	8747	1635	57	5	1061	5	LGALS8	1	236711404	Missense_Mutation	SNP	T	TCGA-32-2494-01A-01D-1353-08	50604380	236711404	12539217	14	16124											
LHCGR	3973	broad.mit.edu	37	chr2	48915481	48915481	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agccatcctccaagcataatCagaatggcatgtcttaatcg	7	11	2	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr2:48915481C>A	uc002rwu.3	-	11	1525	c.1455G>T	c.(1453-1455)CTG>CTT	p.L485L	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	485	Helical; Name=4; (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	CAAGCATAATCAGAATGGCAT	0.453									Familial_Male-Limited_Precocious_Puberty				A	48915481	A	A	48915481	2	1	229	1	0	0	0	0	0	0	0	1	8762	813	29	5		5	LHCGR	2	48915481	Silent	SNP	C	TCGA-32-2494-01A-01D-1353-08		48915481	194283892	15	16125											
CKAP2L	150468	broad.mit.edu	37	chr2	113514209	113514209	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtcctgctttgtgtttctcCaacaaattgtttattaaccc	5	10	1	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr2:113514209C>T	uc002tie.2	-	4	818	c.739G>A	c.(739-741)GGA>AGA	p.G247R	CKAP2L_uc002tif.2_Intron|CKAP2L_uc010yxp.1_Missense_Mutation_p.G82R|CKAP2L_uc010yxq.1_Missense_Mutation_p.G82R	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	247						centrosome					0						TGTGTTTCTCCAACAAATTGT	0.403													T	113514209	T	T	113514209	3	4	229	1	0	0	0	0	1	0	0	0	3443	603	21	3	1522	3	CKAP2L	2	113514209	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	64598728	113514209	129685164	16	16126											
TRAK2	66008	broad.mit.edu	37	chr2	202250994	202250994	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaggaagatccctgttactGgcttggatgttgaaagtttc	12	7	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr2:202250994G>T	uc002uyb.3	-	14	2356	c.1910C>A	c.(1909-1911)CCA>CAA	p.P637Q		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	637				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0						CCCTGTTACTGGCTTGGATGT	0.418													T	202250994	T	T	202250994	3	4	229	1	0	0	0	0	1	0	0	0	16447	1348	47	5	846	5	TRAK2	2	202250994	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	88736785	202250994	40948379	17	16127											
CNTN6	27255	broad.mit.edu	37	chr3	1339583	1339583	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tatttaacaggtgtgatgggGgaatatgaaccaaagattga	12	3	0	4			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:1339583G>T	uc003boz.2	+	7	936	c.669G>T	c.(667-669)GGG>GGT	p.G223G	CNTN6_uc010hbo.2_Silent_p.G218G|CNTN6_uc011asj.1_Silent_p.G151G|CNTN6_uc003bpa.2_Silent_p.G223G	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	223					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GTGTGATGGGGGAATATGAAC	0.353													T	1339583	T	T	1339583	2	4	229	1	0	0	0	0	0	0	0	1	3645	1219	43	5		5	CNTN6	3	1339583	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08		1339583	196682847	18	16128											
ITPR1	3708	broad.mit.edu	37	chr3	4856788	4856788	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctcttgttcttcttcatgGtcatcatcattgttcttaac	4	11	8	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:4856788G>A	uc003bqa.2	+	56	7957	c.7609G>A	c.(7609-7611)GTC>ATC	p.V2537I	ITPR1_uc010hca.1_Missense_Mutation_p.V2522I|ITPR1_uc011asu.1_Missense_Mutation_p.V548I|ITPR1_uc003bqc.2_Missense_Mutation_p.V1507I|ITPR1_uc010hcc.1_Missense_Mutation_p.V305I|ITPR1_uc011asv.1_Missense_Mutation_p.V261I	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2585	Helical; (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTTCTTCATGGTCATCATCAT	0.448													A	4856788	A	A	4856788	3	1	229	1	0	0	0	0	1	0	0	0	7920	1261	44	3	7979	3	ITPR1	3	4856788	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	3517205	4856788	193165642	19	16129											
ATP2B2	491	broad.mit.edu	37	chr3	10452358	10452358	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccccagggagatgatggcgGcaatctccaggatgatgagc	15	10	1	4			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:10452358G>A	uc003bvt.2	-	3	780	c.341C>T	c.(340-342)GCC>GTC	p.A114V	ATP2B2_uc003bvv.2_Missense_Mutation_p.A114V|ATP2B2_uc003bvw.2_Missense_Mutation_p.A114V|ATP2B2_uc010hdp.2_Missense_Mutation_p.A114V|ATP2B2_uc010hdo.2_5'UTR	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	114	Helical; (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GATGATGGCGGCAATCTCCAG	0.592													A	10452358	A	A	10452358	3	1	229	1	0	0	0	0	1	0	0	0	1140	1203	42	3	3474	3	ATP2B2	3	10452358	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	5595570	10452358	187570072	20	16130											
C3orf20	84077	broad.mit.edu	37	chr3	14799018	14799018	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaggcgcccctggtctctgAcgtggagctggagcgcttcc	15	13	1	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:14799018A>C	uc003byy.2	+	13	2485	c.2081A>C	c.(2080-2082)GAC>GCC	p.D694A	C3orf20_uc003byz.2_Missense_Mutation_p.D572A|C3orf20_uc003bza.2_Missense_Mutation_p.D572A|C3orf20_uc003bzb.1_Missense_Mutation_p.D195A|C3orf20_uc011avj.1_Missense_Mutation_p.D21A	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	694						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						CTGGTCTCTGACGTGGAGCTG	0.632													C	14799018	C	C	14799018	3	2	229	1	0	0	0	0	1	0	0	0	2213	275	10	5	2123	5	C3orf20	3	14799018	Missense_Mutation	SNP	A	TCGA-32-2494-01A-01D-1353-08	4346660	14799018	183223412	21	16131											
MYRIP	25924	broad.mit.edu	37	chr3	40231528	40231528	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgagcaagctgtgtcccagGtcccgggccctgcccaggaa	13	14	0	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:40231528G>A	uc003cka.2	+	10	1374	c.1239G>A	c.(1237-1239)AGG>AGA	p.R413R	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.R413R|MYRIP_uc010hhw.2_Silent_p.R324R|MYRIP_uc011ayz.1_Silent_p.R226R|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	413	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		TGTGTCCCAGGTCCCGGGCCC	0.637													A	40231528	A	A	40231528	2	1	229	1	0	0	0	0	0	0	0	1	10100	1252	44	3		3	MYRIP	3	40231528	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08	25432510	40231528	157790902	22	16132											
PIK3CB	5291	broad.mit.edu	37	chr3	138374244	138374244	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgatcgttaagatctgtagTctttccgaactgtgtgggcc	11	9	2	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:138374244T>G	uc011bmq.1	-	22	3200	c.3200A>C	c.(3199-3201)GAC>GCC	p.D1067A	PIK3CB_uc011bmn.1_Missense_Mutation_p.D579A|PIK3CB_uc011bmo.1_Missense_Mutation_p.D518A|PIK3CB_uc011bmp.1_Missense_Mutation_p.D654A|PIK3CB_uc003est.1_RNA	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	1067	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AGATCTGTAGTCTTTCCGAAC	0.408													G	138374244	G	G	138374244	3	3	229	1	0	0	0	0	1	0	0	0	11914	1667	58	5	14	5	PIK3CB	3	138374244	Missense_Mutation	SNP	T	TCGA-32-2494-01A-01D-1353-08	98142716	138374244	59648186	23	16133											
PIK3CB	5291	broad.mit.edu	37	chr3	138374281	138374281	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggccatccagttcactttagTagtccagctttccctgagcg	9	13	1	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:138374281T>C	uc011bmq.1	-	22	3163	c.3163A>G	c.(3163-3165)ACT>GCT	p.T1055A	PIK3CB_uc011bmn.1_Missense_Mutation_p.T567A|PIK3CB_uc011bmo.1_Missense_Mutation_p.T506A|PIK3CB_uc011bmp.1_Missense_Mutation_p.T642A|PIK3CB_uc003est.1_RNA	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	1055	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						TTCACTTTAGTAGTCCAGCTT	0.413													C	138374281	C	C	138374281	3	2	229	1	0	0	0	0	1	0	0	0	11914	1638	57	4	51	4	PIK3CB	3	138374281	Missense_Mutation	SNP	T	TCGA-32-2494-01A-01D-1353-08	37	138374281	59648149	24	16134											
KCNAB1	7881	broad.mit.edu	37	chr3	155838668	155838668	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgtctgcaccacaggcatgCcgcacaggtaagctgcccct	10	17	1	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:155838668C>T	uc003far.2	+	1	332	c.268C>T	c.(268-270)CCG>TCG	p.P90S	KCNAB1_uc011bon.1_Missense_Mutation_p.P90S	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	90						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CACAGGCATGCCGCACAGGTA	0.592													T	155838668	T	T	155838668	3	4	229	1	0	0	0	0	1	0	0	0	8009	739	26	3	270	3	KCNAB1	3	155838668	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	17464387	155838668	42183762	25	16135											
VPS8	23355	broad.mit.edu	37	chr3	184543975	184543975	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	atgacaaggagtttgatattCctcaagttgatactcctcca	7	9	1	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:184543975C>G	uc003fpb.1	+	3	349	c.178C>G	c.(178-180)CCT>GCT	p.P60A	VPS8_uc010hyd.1_Missense_Mutation_p.P60A|VPS8_uc003fpc.1_Missense_Mutation_p.P60A	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	60							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GTTTGATATTCCTCAAGTTGA	0.318													G	184543975	G	G	184543975	3	3	229	1	0	0	0	0	1	0	0	0	17215	855	30	5	184	5	VPS8	3	184543975	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	28705307	184543975	13478455	26	16136											
ACAP2	23527	broad.mit.edu	37	chr3	195012473	195012473	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggcatggtgcaatggtccCcgcccttggacatctctttg	12	12	1	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr3:195012473C>T	uc003fun.3	-	20	2266	c.2025G>A	c.(2023-2025)CGG>CGA	p.R675R		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	675	ANK 2.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GCAATGGTCCCCGCCCTTGGA	0.413													T	195012473	T	T	195012473	2	4	229	1	0	0	0	0	0	0	0	1	119	610	22	3		3	ACAP2	3	195012473	Silent	SNP	C	TCGA-32-2494-01A-01D-1353-08	10468498	195012473	3009957	27	16137											
AFP	174	broad.mit.edu	37	chr4	74316398	74316398	+	Frame_Shift_Del	DEL	A	-	-													gagctgatggccatcaccagAaaaatggcagccacagcagc							TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr4:74316398delA	uc003hgz.1	+	11	1403	c.1356delA	c.(1354-1356)AGAfs	p.R452fs	AFP_uc003hha.1_Frame_Shift_Del_p.R452fs|AFP_uc011cbg.1_Frame_Shift_Del_p.R226fs	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	452	Albumin 3.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCATCACCAGAAAAATGGCAG	0.517									Alpha-Fetoprotein_Hereditary_Persistence_of				-	74316398	-	-	74316398	7	5	229	1	0	1	0	1	0	0	0	0	363	243	9	0	1398	0	AFP	4	74316398	Frame_Shift_Del	DEL	A	TCGA-32-2494-01A-01D-1353-08		74316398	116837878	28	16138											
AFF1	4299	broad.mit.edu	37	chr4	88048823	88048823	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaccttcacatgagggagGcaaaaaagatgaagcagaaa	11	7	1	5			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr4:88048823G>A	uc003hqj.3	+	15	3318	c.2911G>A	c.(2911-2913)GCA>ACA	p.A971T	AFF1_uc011ccz.1_Missense_Mutation_p.A978T|AFF1_uc003hqk.3_Missense_Mutation_p.A971T|AFF1_uc011cda.1_Missense_Mutation_p.A609T	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	971						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CATGAGGGAGGCAAAAAAGAT	0.378													A	88048823	A	A	88048823	3	1	229	1	0	0	0	0	1	0	0	0	356	1203	42	3	3011	3	AFF1	4	88048823	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	13732425	88048823	103105453	29	16139											
NR3C2	4306	broad.mit.edu	37	chr4	149181209	149181209	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcctgaagcctcatccccAcacaccaaacatatttttga	3	15	1	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr4:149181209A>C	uc003ilj.3	-	3	2152	c.1818T>G	c.(1816-1818)TGT>TGG	p.C606W	NR3C2_uc003ilk.3_Missense_Mutation_p.C606W|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	606	NR C4-type.|Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	CCTCATCCCCACACACCAAAC	0.413													C	149181209	C	C	149181209	3	2	229	1	0	0	0	0	1	0	0	0	10631	157	6	5	1164	5	NR3C2	4	149181209	Missense_Mutation	SNP	A	TCGA-32-2494-01A-01D-1353-08	61132386	149181209	41973067	30	16140											
POC5	134359	broad.mit.edu	37	chr5	74998543	74998543	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atctgtatgactagaatttgTtgctggtgaggaagagtcag	13	4	2	4			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr5:74998543T>C	uc003keh.3	-	5	597	c.400A>G	c.(400-402)ACA>GCA	p.T134A	POC5_uc010izu.2_Missense_Mutation_p.T17A|POC5_uc003keg.3_Missense_Mutation_p.T109A	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	134					cell cycle	centriole				lung(1)	1						CTAGAATTTGTTGCTGGTGAG	0.403													C	74998543	C	C	74998543	3	2	229	1	0	0	0	0	1	0	0	0	12177	1725	60	4	1359	4	POC5	5	74998543	Missense_Mutation	SNP	T	TCGA-32-2494-01A-01D-1353-08		74998543	105916717	31	16141											
HIVEP1	3096	broad.mit.edu	37	chr6	12121493	12121493	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacttagtattcattcagacGtagaagacagtggggagagc	12	7	2	4			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr6:12121493G>A	uc003nac.2	+	4	1644	c.1465G>A	c.(1465-1467)GTA>ATA	p.V489I	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	489					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TCATTCAGACGTAGAAGACAG	0.527													A	12121493	A	A	12121493	3	1	229	1	0	0	0	0	1	0	0	0	7186	1145	40	1	1475	1	HIVEP1	6	12121493	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08		12121493	158993574	32	16142											
SNX14	57231	broad.mit.edu	37	chr6	86258062	86258062	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aaggaaggaacacagagccaGacagaatctctcttataagt	9	8	2	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr6:86258062G>C	uc003pkr.2	-	9	1017	c.824C>G	c.(823-825)TCT>TGT	p.S275C	SNX14_uc003pkp.2_Missense_Mutation_p.S138C|SNX14_uc003pkq.2_5'UTR|SNX14_uc011dzg.1_Missense_Mutation_p.S223C|SNX14_uc003pks.2_Missense_Mutation_p.S231C|SNX14_uc003pkt.2_Missense_Mutation_p.S275C	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	275	PXA.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CACAGAGCCAGACAGAATCTC	0.219													C	86258062	C	C	86258062	3	2	229	1	0	0	0	0	1	0	0	0	14885	942	33	5	2100	5	SNX14	6	86258062	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	74136569	86258062	84857005	33	16143											
SIM1	6492	broad.mit.edu	37	chr6	100901720	100901720	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccccacgcctcgccgagcCctgtggagacacagaagcat	12	16	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr6:100901720C>T	uc003pqj.3	-	2	383	c.176G>A	c.(175-177)GGG>GAG	p.G59E	SIM1_uc010kcu.2_Missense_Mutation_p.G59E	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	59					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CTCGCCGAGCCCTGTGGAGAC	0.627													T	100901720	T	T	100901720	3	4	229	1	0	0	0	0	1	0	0	0	14323	637	22	3	2164	3	SIM1	6	100901720	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	14643658	100901720	70213347	34	16144											
BVES	11149	broad.mit.edu	37	chr6	105549004	105549004	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaatgtatttggagatgccGgttcaaaaacgtcatcatca	8	8	5	1	rs138992583		TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr6:105549004G>A	uc003pqw.2	-	8	1200	c.1043C>T	c.(1042-1044)CCG>CTG	p.P348L	BVES_uc003pqx.2_Missense_Mutation_p.P348L|BVES_uc003pqy.2_Missense_Mutation_p.P348L	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	348	Cytoplasmic (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				TGGAGATGCCGGTTCAAAAAC	0.453													A	105549004	A	A	105549004	3	1	229	1	0	0	0	0	1	0	0	0	1575	1116	39	2	43	2	BVES	6	105549004	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	4647284	105549004	65566063	35	16145											
TIAM2	26230	broad.mit.edu	37	chr6	155498003	155498003	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtagacggtgttccccgagaCaatgcatgggaaatccagac	12	10	0	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr6:155498003C>A	uc003qqb.2	+	12	3688	c.2415C>A	c.(2413-2415)GAC>GAA	p.D805E	TIAM2_uc003qqe.2_Missense_Mutation_p.D805E|TIAM2_uc010kjj.2_Missense_Mutation_p.D338E|TIAM2_uc003qqf.2_Missense_Mutation_p.D181E|TIAM2_uc011efl.1_Missense_Mutation_p.D141E|TIAM2_uc003qqg.2_Missense_Mutation_p.D117E	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	805					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TTCCCCGAGACAATGCATGGG	0.408													A	155498003	A	A	155498003	3	1	229	1	0	0	0	0	1	0	0	0	15888	477	17	5	2441	5	TIAM2	6	155498003	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	49948999	155498003	15617064	36	16146											
FNDC1	84624	broad.mit.edu	37	chr6	159672498	159672498	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaacatcaccgtggtggccGtggaaggttgccactcattt	12	11	2	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr6:159672498G>A	uc010kjv.2	+	17	5199	c.4999G>A	c.(4999-5001)GTG>ATG	p.V1667M		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1667	Fibronectin type-III 5.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CGTGGTGGCCGTGGAAGGTTG	0.537													A	159672498	A	A	159672498	3	1	229	1	0	0	0	0	1	0	0	0	5968	1145	40	1	5065	1	FNDC1	6	159672498	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	4174495	159672498	11442569	37	16147											
MAD1L1	8379	broad.mit.edu	37	chr7	2255875	2255875	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agctcagacttcatgttcttCacaatcgctgcatcctgctc	6	14	4	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr7:2255875C>T	uc003slh.1	-	8	992	c.726G>A	c.(724-726)GTG>GTA	p.V242V	MAD1L1_uc003sle.1_5'Flank|MAD1L1_uc003slf.1_Silent_p.V242V|MAD1L1_uc003slg.1_Silent_p.V242V|MAD1L1_uc010ksh.1_Silent_p.V242V|MAD1L1_uc003sli.1_Silent_p.V150V|MAD1L1_uc010ksi.1_Silent_p.V195V|MAD1L1_uc010ksj.2_Silent_p.V242V	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	242	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TCATGTTCTTCACAATCGCTG	0.493													T	2255875	T	T	2255875	2	4	229	1	0	0	0	0	0	0	0	1	9147	813	29	3		3	MAD1L1	7	2255875	Silent	SNP	C	TCGA-32-2494-01A-01D-1353-08		2255875	156882788	38	16148											
HOXA13	3209	broad.mit.edu	37	chr7	27238936	27238936	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggcccccgaggcccggcaccActggcatatccaggtagcca	12	17	0	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr7:27238936A>G	uc003szb.1	-	1	790	c.761T>C	c.(760-762)GTG>GCG	p.V254A	uc003szc.1_5'Flank	NM_000522	NP_000513	P31271	HXA13_HUMAN	homeobox A13	254					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)	1						GCCCGGCACCACTGGCATATC	0.672			T	NUP98	AML								G	27238936	G	G	27238936	3	3	229	1	0	0	0	0	1	0	0	0	7291	159	6	4	413	4	HOXA13	7	27238936	Missense_Mutation	SNP	A	TCGA-32-2494-01A-01D-1353-08	24983061	27238936	131899727	39	16149											
ASZ1	136991	broad.mit.edu	37	chr7	117067510	117067510	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcctcgcagcgcgctcgccGccatgccagccaaggaagct	13	17	0	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr7:117067510G>A	uc003vjb.2	-	1	68	c.5C>T	c.(4-6)GCG>GTG	p.A2V	ASZ1_uc011kno.1_Missense_Mutation_p.A2V|ASZ1_uc011knp.1_5'UTR	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	2					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CGCGCTCGCCGCCATGCCAGC	0.692											OREG0003439	type=REGULATORY REGION|Gene=ASZ1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	A	117067510	A	A	117067510	3	1	229	1	0	0	0	0	1	0	0	0	1069	1087	38	1	1474	1	ASZ1	7	117067510	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	89828574	117067510	42071153	40	16150											
TRPV6	55503	broad.mit.edu	37	chr7	142575507	142575507	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagagggctgctatgtgtagCgctgtttcccccatggctcc	12	12	0	1	rs145875993		TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr7:142575507C>T	uc003wbx.1	-	3	462	c.246G>A	c.(244-246)GCG>GCA	p.A82A	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_5'UTR	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	82	Cytoplasmic (Potential).|ANK 2.				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CTATGTGTAGCGCTGTTTCCC	0.562													T	142575507	T	T	142575507	2	4	229	1	0	0	0	0	0	0	0	1	16597	755	27	1		1	TRPV6	7	142575507	Silent	SNP	C	TCGA-32-2494-01A-01D-1353-08	25507997	142575507	16563156	41	16151											
DPYSL2	1808	broad.mit.edu	37	chr8	26492400	26492400	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agctctgctgaggtcatcgcCcaggcacggaagaagggtga	15	10	2	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr8:26492400C>A	uc003xfb.1	+	8	1145	c.795C>A	c.(793-795)GCC>GCA	p.A265A	DPYSL2_uc003xfa.2_Silent_p.A370A|DPYSL2_uc011lag.1_Silent_p.A265A|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Silent_p.A229A	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	265					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		AGGTCATCGCCCAGGCACGGA	0.607													A	26492400	A	A	26492400	2	1	229	1	0	0	0	0	0	0	0	1	4747	610	22	5		5	DPYSL2	8	26492400	Silent	SNP	C	TCGA-32-2494-01A-01D-1353-08		26492400	119871622	42	16152											
LYN	4067	broad.mit.edu	37	chr8	56854426	56854426	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaacaggaaatatgggatGtataaaatcaaaagggaaag	10	3	2	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr8:56854426G>A	uc003xsk.3	+	2	290	c.8G>A	c.(7-9)TGT>TAT	p.C3Y	LYN_uc003xsl.3_Missense_Mutation_p.C3Y	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	3				C->A: Loss of localization to the cell membrane; when associated with A-2.	erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			AATATGGGATGTATAAAATCA	0.343													A	56854426	A	A	56854426	3	1	229	1	0	0	0	0	1	0	0	0	9107	1377	48	3	10	3	LYN	8	56854426	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	30362026	56854426	89509596	43	16153											
DMRT2	10655	broad.mit.edu	37	chr9	1056405	1056405	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctctgtttctgcccaaccGcatggtgcctggacctgact	10	14	2	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr9:1056405G>A	uc003zha.2	+	4	1018	c.818G>A	c.(817-819)CGC>CAC	p.R273H	DMRT2_uc003zgx.3_Missense_Mutation_p.R40H|DMRT2_uc010mgz.2_Missense_Mutation_p.R40H|DMRT2_uc003zgy.3_Missense_Mutation_p.R117H|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Missense_Mutation_p.R273H	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	273					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		CTGCCCAACCGCATGGTGCCT	0.473													A	1056405	A	A	1056405	3	1	229	1	0	0	0	0	1	0	0	0	4586	1087	38	1	885	1	DMRT2	9	1056405	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08		1056405	140157026	44	16154											
KIAA1045	23349	broad.mit.edu	37	chr9	34971375	34971375	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtctgctttcaaggatgGgctgcgggacaggccttcca	14	10	2	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr9:34971375G>T	uc003zvq.2	+	2	258	c.80G>T	c.(79-81)GGG>GTG	p.G27V	KIAA1045_uc003zvr.2_Missense_Mutation_p.G27V	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	27							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			TTCAAGGATGGGCTGCGGGAC	0.607													T	34971375	T	T	34971375	3	4	229	1	0	0	0	0	1	0	0	0	8207	1232	43	5	82	5	KIAA1045	9	34971375	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	33914970	34971375	106242056	45	16155											
OR13C3	138803	broad.mit.edu	37	chr9	107298263	107298263	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtaccgtaaaatatgatcaCcacagtcaggtgagctgagc	11	9	2	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr9:107298263C>A	uc004bcb.1	-	1	832	c.832G>T	c.(832-834)GTG>TTG	p.V278L		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	278	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						AATATGATCACCACAGTCAGG	0.418													A	107298263	A	A	107298263	3	1	229	1	0	0	0	0	1	0	0	0	10935	507	18	5	215	5	OR13C3	9	107298263	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	72326888	107298263	33915168	46	16156											
MYO3A	53904	broad.mit.edu	37	chr10	26312961	26312961	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttttctaggaatccacccCcaaaactaaggcagcctgag	7	12	1	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr10:26312961C>T	uc001isn.2	+	9	1102	c.742C>T	c.(742-744)CCA>TCA	p.P248S	MYO3A_uc009xko.1_Missense_Mutation_p.P248S|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.P248S	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	248	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GAATCCACCCCCAAAACTAAG	0.388													T	26312961	T	T	26312961	3	4	229	1	0	0	0	0	1	0	0	0	10076	623	22	3	768	3	MYO3A	10	26312961	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08		26312961	109221786	47	16157											
GDF10	2662	broad.mit.edu	37	chr10	48429323	48429323	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgccagggccatggccccgCggagtagcccctgtgtggcc	16	16	0	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr10:48429323C>T	uc001jfb.2	-	2	1019	c.563G>A	c.(562-564)CGC>CAC	p.R188H	GDF10_uc009xnp.2_Missense_Mutation_p.R187H|GDF10_uc009xnq.1_Missense_Mutation_p.R188H	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	188					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CATGGCCCCGCGGAGTAGCCC	0.731													T	48429323	T	T	48429323	3	4	229	1	0	0	0	0	1	0	0	0	6311	768	27	1	881	1	GDF10	10	48429323	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	22116362	48429323	87105424	48	16158											
ZNF195	7748	broad.mit.edu	37	chr11	3381676	3381676	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctcatctaaactttcccagtCtttccttaaatataaattat	1	10	3	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr11:3381676C>G	uc001lxt.2	-	6	740	c.562G>C	c.(562-564)GAC>CAC	p.D188H	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Missense_Mutation_p.D165H|ZNF195_uc001lxs.2_Missense_Mutation_p.D116H|ZNF195_uc010qxr.1_Missense_Mutation_p.D169H|ZNF195_uc009ydz.2_Missense_Mutation_p.D143H|ZNF195_uc001lxu.2_Missense_Mutation_p.D120H	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	188	Spacer.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		CTTTCCCAGTCTTTCCTTAAA	0.343													G	3381676	G	G	3381676	3	3	229	1	0	0	0	0	1	0	0	0	17755	913	32	5	1331	5	ZNF195	11	3381676	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08		3381676	131624840	49	16159											
CD44	960	broad.mit.edu	37	chr11	35226085	35226085	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	caactcctagtagtacaacgGaagaaacagctacccagaag	8	11	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr11:35226085G>T	uc001mvu.2	+	10	1614	c.1180G>T	c.(1180-1182)GAA>TAA	p.E394*	CD44_uc001mvv.2_Nonsense_Mutation_p.E351*|CD44_uc001mvw.2_Intron|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Intron|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron|CD44_uc010res.1_Intron|CD44_uc010ret.1_Intron|CD44_uc010reu.1_Intron	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	394	Extracellular (Potential).|Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	TAGTACAACGGAAGAAACAGC	0.453													T	35226085	T	T	35226085	4	4	229	1	0	0	0	0	0	1	0	0	3017	1175	41	5	1218	5	CD44	11	35226085	Nonsense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	31844409	35226085	99780431	50	16160											
PTPRJ	5795	broad.mit.edu	37	chr11	48134462	48134462	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgaaagctctggagccaaCgatagtttaagaacacctga	11	8	1	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr11:48134462C>T	uc001ngp.3	+	3	634	c.279C>T	c.(277-279)AAC>AAT	p.N93N	PTPRJ_uc001ngo.3_Silent_p.N93N	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	93	Extracellular (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						CTGGAGCCAACGATAGTTTAA	0.453													T	48134462	T	T	48134462	2	4	229	1	0	0	0	0	0	0	0	1	12804	535	19	1		1	PTPRJ	11	48134462	Silent	SNP	C	TCGA-32-2494-01A-01D-1353-08	12908377	48134462	86872054	51	16161											
SLC29A2	3177	broad.mit.edu	37	chr11	66133408	66133409	+	Missense_Mutation	DNP	CA	AC	AC													ccagccctggtgtgcttaccCacaggaagtaagaggtcagg							TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr11:66133408_66133409CA>AC	uc001oht.2	-	10	1286_1287	c.1057_1058TG>GT	c.(1057-1059)TGG>GTG	p.W353V	SLC29A2_uc001ohs.2_Missense_Mutation_p.W233V|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_Missense_Mutation_p.W233V|SLC29A2_uc001ohu.2_Missense_Mutation_p.W353V|SLC29A2_uc001ohv.2_Missense_Mutation_p.V308G|uc001ohw.1_5'Flank	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	353					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1						TGTGCTTACCCACAGGAAGTAA	0.535													AC	66133409	AC	AC	66133408	3	1	229	1	0	0	0	0	1	0	0	0	14535	608	21	5	324	5	SLC29A2	11	66133408	Missense_Mutation	DNP	CA	TCGA-32-2494-01A-01D-1353-08	17998946	66133408	68873108	52	16162											
C11orf82	220042	broad.mit.edu	37	chr11	82639902	82639905	+	Frame_Shift_Del	DEL	CAAA	-	-													ttccttaaaagttgcagaatCaaacaaattgtttgttatta							TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr11:82639902_82639905delCAAA	uc001ozt.2	+	4	441_444	c.197_200delCAAA	c.(196-201)TCAAACfs	p.S66fs	C11orf82_uc010rsr.1_5'UTR|C11orf82_uc010rss.1_Intron|C11orf82_uc009yvd.2_Frame_Shift_Del_p.S66fs	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	66_67					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						GTTGCAGAATCAAACAAATTGTTT	0.343													-	82639905	-	-	82639902	7	5	229	1	0	1	0	1	0	0	0	0	1665	838	29	0	203	0	C11orf82	11	82639902	Frame_Shift_Del	DEL	CAAA	TCGA-32-2494-01A-01D-1353-08	16506494	82639902	52366614	53	16163											
ROBO4	54538	broad.mit.edu	37	chr11	124764984	124764984	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctagtgggggtacctggtagCcacggatgatgccattgtgg	16	8	0	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr11:124764984C>T	uc001qbg.2	-	7	1282	c.1142G>A	c.(1141-1143)GGC>GAC	p.G381D	ROBO4_uc010sas.1_Missense_Mutation_p.G236D|ROBO4_uc001qbh.2_Missense_Mutation_p.G271D|ROBO4_uc001qbi.2_5'Flank|ROBO4_uc010sat.1_5'UTR	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	381	Fibronectin type-III 2.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TACCTGGTAGCCACGGATGAT	0.542													T	124764984	T	T	124764984	3	4	229	1	0	0	0	0	1	0	0	0	13516	739	26	3	1929	3	ROBO4	11	124764984	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	42125082	124764984	10241532	54	16164											
VEZT	55591	broad.mit.edu	37	chr12	95660405	95660405	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgatttccagaggatttaCactgtgagttcattttttat	8	5	1	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr12:95660405C>T	uc001tdz.2	+	5	812	c.707C>T	c.(706-708)ACA>ATA	p.T236I	VEZT_uc009zsy.1_Missense_Mutation_p.T78I|VEZT_uc001tdr.2_Missense_Mutation_p.T78I|VEZT_uc001tds.2_Missense_Mutation_p.T188I|VEZT_uc001tdt.2_Missense_Mutation_p.T188I|VEZT_uc009zsz.1_Missense_Mutation_p.T236I|VEZT_uc001tdv.2_Missense_Mutation_p.T205I|VEZT_uc001tdw.1_Missense_Mutation_p.T188I|VEZT_uc009zta.1_Missense_Mutation_p.T188I	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	236						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						AGAGGATTTACACTGTGAGTT	0.313													T	95660405	T	T	95660405	3	4	229	1	0	0	0	0	1	0	0	0	17153	478	17	3	725	3	VEZT	12	95660405	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08		95660405	38191490	55	16165											
STAB2	55576	broad.mit.edu	37	chr12	104147041	104147041	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacgctccccactgggccaGtataagctgacctttgacaa	8	14	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr12:104147041G>A	uc001tjw.2	+	61	6810	c.6624G>A	c.(6622-6624)CAG>CAA	p.Q2208Q	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2208	Extracellular (Potential).|Link.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CACTGGGCCAGTATAAGCTGA	0.567													A	104147041	A	A	104147041	2	1	229	1	0	0	0	0	0	0	0	1	15237	1020	36	3		3	STAB2	12	104147041	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08	8486636	104147041	29704854	56	16166											
ABCB9	23457	broad.mit.edu	37	chr12	123434439	123434439	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaatatgagggtaaaaatgCcgccccgaatacctgcggca	10	11	0	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr12:123434439C>T	uc001udm.3	-	4	1053	c.743G>A	c.(742-744)GGC>GAC	p.G248D	ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Missense_Mutation_p.G248D|ABCB9_uc010taj.1_Missense_Mutation_p.G248D|ABCB9_uc001udp.2_Missense_Mutation_p.G248D|ABCB9_uc001udq.2_Missense_Mutation_p.G30D|ABCB9_uc001udr.2_Missense_Mutation_p.G248D	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	248	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		GGTAAAAATGCCGCCCCGAAT	0.522													T	123434439	T	T	123434439	3	4	229	1	0	0	0	0	1	0	0	0	48	739	26	3	1593	3	ABCB9	12	123434439	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	19287398	123434439	10417456	57	16167											
NCOR2	9612	broad.mit.edu	37	chr12	124857156	124857156	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgagctgttgttgacagtgGctgtgcagggcgagaaggaa	17	6	0	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr12:124857156G>A	uc010tba.1	-	20	2336	c.2219C>T	c.(2218-2220)GCC>GTC	p.A740V	NCOR2_uc010tay.1_Missense_Mutation_p.A740V|NCOR2_uc010taz.1_Missense_Mutation_p.A723V|NCOR2_uc010tbb.1_Missense_Mutation_p.A740V|NCOR2_uc010tbc.1_Missense_Mutation_p.A722V|NCOR2_uc001ugj.1_Missense_Mutation_p.A740V	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	740					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GTTGACAGTGGCTGTGCAGGG	0.647													A	124857156	A	A	124857156	3	1	229	1	0	0	0	0	1	0	0	0	10236	1217	42	3	5461	3	NCOR2	12	124857156	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	1422717	124857156	8994739	58	16168											
PIWIL1	9271	broad.mit.edu	37	chr12	130830969	130830969	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatttccggctgacatcccGtccccagtgggccttatatc	8	16	0	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr12:130830969G>A	uc001uik.2	+	5	461	c.371G>A	c.(370-372)CGT>CAT	p.R124H	PIWIL1_uc001uij.1_Missense_Mutation_p.R124H	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	124					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CTGACATCCCGTCCCCAGTGG	0.393													A	130830969	A	A	130830969	3	1	229	1	0	0	0	0	1	0	0	0	11957	1145	40	1	385	1	PIWIL1	12	130830969	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	5973813	130830969	3020926	59	16169											
ENOX1	55068	broad.mit.edu	37	chr13	43788215	43788215	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaattcctgtttgaacatgcGtggcagcctcatcaaaagca	9	10	2	1	rs146880051		TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr13:43788215G>A	uc001uza.3	-	17	2143	c.1843C>T	c.(1843-1845)CGC>TGC	p.R615C	ENOX1_uc001uzb.3_Missense_Mutation_p.R615C|ENOX1_uc001uzc.3_Missense_Mutation_p.R615C|ENOX1_uc001uyz.3_Missense_Mutation_p.R224C	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	615					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TTGAACATGCGTGGCAGCCTC	0.433													A	43788215	A	A	43788215	3	1	229	1	0	0	0	0	1	0	0	0	5126	1145	40	1	92	1	ENOX1	13	43788215	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08		43788215	71381663	60	16170											
HEATR5A	25938	broad.mit.edu	37	chr14	31790820	31790820	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaaagacggagctggtcaCtgtgatctgtggcagccata	13	9	2	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr14:31790820C>T	uc001wrf.3	-	19	3052	c.2975G>A	c.(2974-2976)AGT>AAT	p.S992N	HEATR5A_uc010ami.2_Missense_Mutation_p.S890N	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1279							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		GAGCTGGTCACTGTGATCTGT	0.408													T	31790820	T	T	31790820	3	4	229	1	0	0	0	0	1	0	0	0	7031	565	20	3	2334	3	HEATR5A	14	31790820	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08		31790820	75558720	61	16171											
FOS	2353	broad.mit.edu	37	chr14	75745716	75745716	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cgggcttcaacgcagactacGaggcgtcatcctcccgctgc	11	16	2	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr14:75745716G>C	uc001xrn.2	+	1	236	c.31G>C	c.(31-33)GAG>CAG	p.E11Q	FOS_uc010tva.1_Missense_Mutation_p.E11Q|FOS_uc010asi.2_5'Flank|FOS_uc001xro.2_5'Flank	NM_005252	NP_005243	P01100	FOS_HUMAN	v-fos FBJ murine osteosarcoma viral oncogene	11					cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(2)|ovary(1)	3		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		CGCAGACTACGAGGCGTCATC	0.662													C	75745716	C	C	75745716	3	2	229	1	0	0	0	0	1	0	0	0	5985	1059	37	5	33	5	FOS	14	75745716	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	43954896	75745716	31603824	62	16172											
KCNK13	56659	broad.mit.edu	37	chr14	90650893	90650893	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagagccaaggcctctatcGctttgccaacttcgtcttca	8	13	3	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr14:90650893G>A	uc001xye.1	+	2	1215	c.773G>A	c.(772-774)CGC>CAC	p.R258H		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	258						integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				GGCCTCTATCGCTTTGCCAAC	0.493													A	90650893	A	A	90650893	3	1	229	1	0	0	0	0	1	0	0	0	8061	1087	38	1	779	1	KCNK13	14	90650893	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	14905177	90650893	16698647	63	16173											
RYR3	6263	broad.mit.edu	37	chr15	34014993	34014993	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgcttcggcccggccctgCggggtgaggggggaaacggg	21	10	0	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr15:34014993C>T	uc001zhi.2	+	44	6767	c.6697C>T	c.(6697-6699)CGG>TGG	p.R2233W	RYR3_uc010bar.2_Missense_Mutation_p.R2233W	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2233	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCCGGCCCTGCGGGGTGAGGG	0.587													T	34014993	T	T	34014993	3	4	229	1	0	0	0	0	1	0	0	0	13770	759	27	1	6871	1	RYR3	15	34014993	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08		34014993	68516399	64	16174											
CILP	8483	broad.mit.edu	37	chr15	65495753	65495753	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccttacagcacagagacacGctctgcccagctctccgtgc	9	17	2	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr15:65495753G>A	uc002aon.2	-	7	1156	c.975C>T	c.(973-975)AGC>AGT	p.S325S		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	325	Ig-like C2-type.				negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						ACAGAGACACGCTCTGCCCAG	0.498													A	65495753	A	A	65495753	2	1	229	1	0	0	0	0	0	0	0	1	3429	1078	38	1		1	CILP	15	65495753	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08	31480760	65495753	37035639	65	16175											
SCAMP2	10066	broad.mit.edu	37	chr15	75137888	75137888	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caccatcatgatgactgataTggccagggaatgattatcca	9	9	1	4			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr15:75137888T>G	uc002azb.1	-	8	855	c.781A>C	c.(781-783)ATA>CTA	p.I261L	ULK3_uc010ulp.1_5'Flank|ULK3_uc010ulq.1_5'Flank|ULK3_uc010ulr.1_5'Flank|ULK3_uc010bkf.1_5'Flank|ULK3_uc002ayv.2_5'Flank|ULK3_uc010uls.1_5'Flank|ULK3_uc010ult.1_5'Flank|ULK3_uc010ulu.1_5'Flank|SCAMP2_uc002aza.1_Missense_Mutation_p.I111L|SCAMP2_uc010bkg.1_RNA	NM_005697	NP_005688	O15127	SCAM2_HUMAN	secretory carrier membrane protein 2	261	Lumenal (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane|nucleus|recycling endosome membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						ATGACTGATATGGCCAGGGAA	0.557													G	75137888	G	G	75137888	3	3	229	1	0	0	0	0	1	0	0	0	13871	1464	51	5	216	5	SCAMP2	15	75137888	Missense_Mutation	SNP	T	TCGA-32-2494-01A-01D-1353-08	9642135	75137888	27393504	66	16176											
ADCY9	115	broad.mit.edu	37	chr16	4033331	4033331	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	acggtggccgcctcgtacttCaggaagcaggtggtggacag	16	10	1	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr16:4033331C>T	uc002cvx.2	-	7	2960	c.2421G>A	c.(2419-2421)CTG>CTA	p.L807L		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	807	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						CCTCGTACTTCAGGAAGCAGG	0.637											OREG0023573	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	4033331	T	T	4033331	2	4	229	1	0	0	0	0	0	0	0	1	301	813	29	3		3	ADCY9	16	4033331	Silent	SNP	C	TCGA-32-2494-01A-01D-1353-08		4033331	86321422	67	16177											
RBL2	5934	broad.mit.edu	37	chr16	53500990	53500990	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtcatgccacctcagaacctGgaaagggcagatgaaatttg	11	9	2	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr16:53500990G>T	uc002ehi.3	+	14	2002	c.1884G>T	c.(1882-1884)CTG>CTT	p.L628L	RBL2_uc010vgv.1_Silent_p.L554L|RBL2_uc002ehj.2_Silent_p.L338L|RBL2_uc010vgw.1_Silent_p.L412L	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	628	Spacer.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CTCAGAACCTGGAAAGGGCAG	0.423													T	53500990	T	T	53500990	2	4	229	1	0	0	0	0	0	0	0	1	13110	1335	47	5		5	RBL2	16	53500990	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08	49467659	53500990	36853763	68	16178											
NOB1	28987	broad.mit.edu	37	chr16	69782153	69782153	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acttgaaacagccatggcagCgcaagatgtagctccgggcc	12	12	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr16:69782153C>A	uc002exs.2	-	7	822	c.806G>T	c.(805-807)CGC>CTC	p.R269L		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	269						nucleus	metal ion binding|protein binding				0						GCCATGGCAGCGCAAGATGTA	0.473													A	69782153	A	A	69782153	3	1	229	1	0	0	0	0	1	0	0	0	10511	768	27	5	444	5	NOB1	16	69782153	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	16281163	69782153	20572600	69	16179											
CLDN7	1366	broad.mit.edu	37	chr17	7163801	7163801	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagagcagtgcacctcccagGatgactagggcagaccctgc	13	13	0	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr17:7163801G>A	uc002gfm.3	-	4	961	c.528C>T	c.(526-528)ATC>ATT	p.I176I	CLDN7_uc010cmc.2_3'UTR|CLDN7_uc002gfn.3_Silent_p.I176I	NM_001307	NP_001298	O95471	CLD7_HUMAN	claudin 7	176	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to membrane|lateral plasma membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						CACCTCCCAGGATGACTAGGG	0.572													A	7163801	A	A	7163801	2	1	229	1	0	0	0	0	0	0	0	1	3490	1164	41	3		3	CLDN7	17	7163801	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08		7163801	74031409	70	16180											
CDRT15	146822	broad.mit.edu	37	chr17	14139674	14139674	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagtgctctctctggaggGgcctcttcccatgctggctc	11	15	3	0	rs141627800		TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr17:14139674G>A	uc010vvu.1	-	2	336	c.336C>T	c.(334-336)GCC>GCT	p.A112A	CDRT15_uc010coq.2_RNA	NM_001007530	NP_001007531	Q96T59	CDRTF_HUMAN	CMT1A duplicated region transcript 15	112											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		TCTCTGGAGGGGCCTCTTCCC	0.607													A	14139674	A	A	14139674	2	1	229	1	0	0	0	0	0	0	0	1	3175	1219	43	3		3	CDRT15	17	14139674	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08	6975873	14139674	67055536	71	16181											
NF1	4763	broad.mit.edu	37	chr17	29508438	29508438	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttaaaaattgtgttttttccAgaaacagcatttaaatttaa	4	4	0	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr17:29508438A>G	uc002hgg.2	+	6	920	c.587_splice	c.e6-2	p.E196_splice	NF1_uc002hge.1_Splice_Site_p.E196_splice|NF1_uc002hgf.1_Splice_Site_p.E196_splice|NF1_uc002hgh.2_Splice_Site_p.E196_splice|NF1_uc010csn.1_Splice_Site_p.E56_splice	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGTTTTTTCCAGAAACAGCAT	0.299			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			G	29508438	G	G	29508438	5	3	229	1	0	0	0	0	0	0	1	0	10356	202	7	4	607	4	NF1	17	29508438	Splice_Site	SNP	A	TCGA-32-2494-01A-01D-1353-08	15368764	29508438	51686772	72	16182											
TADA2A	6871	broad.mit.edu	37	chr17	35834667	35834667	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctctgtctataggtagacGgagtgcaccacccttgaacc	9	12	2	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr17:35834667G>A	uc002hnt.2	+	15	1236	c.1079G>A	c.(1078-1080)CGG>CAG	p.R360Q	TADA2A_uc002hnv.2_Missense_Mutation_p.R360Q|TADA2A_uc002hnw.2_Missense_Mutation_p.R259Q|TADA2A_uc010cvb.2_Missense_Mutation_p.R156Q	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	360	SWIRM.				histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						ATAGGTAGACGGAGTGCACCA	0.453													A	35834667	A	A	35834667	3	1	229	1	0	0	0	0	1	0	0	0	15507	1116	39	2	1228	2	TADA2A	17	35834667	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	6326229	35834667	45360543	73	16183											
KRT12	3859	broad.mit.edu	37	chr17	39021192	39021192	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcggcctctacgccctggcGcagggccagttcattctcat	11	15	3	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr17:39021192G>A	uc002hvk.2	-	3	697	c.673C>T	c.(673-675)CGC>TGC	p.R225C		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	225	Rod.|Coil 1B.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				ACGCCCTGGCGCAGGGCCAGT	0.552													A	39021192	A	A	39021192	3	1	229	1	0	0	0	0	1	0	0	0	8449	1087	38	1	835	1	KRT12	17	39021192	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	3186525	39021192	42174018	74	16184											
TANC2	26115	broad.mit.edu	37	chr17	61466072	61466072	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ttatagcacagaaggtctttCcatggcactggcgtctttac	9	10	2	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr17:61466072C>G	uc002jal.3	+	14	2569	c.2546C>G	c.(2545-2547)TCC>TGC	p.S849C	TANC2_uc010wpe.1_Missense_Mutation_p.S759C|TANC2_uc002jan.1_5'UTR|TANC2_uc002jao.3_5'Flank|TANC2_uc002jam.1_Missense_Mutation_p.S216C	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	849	ANK 1.						binding			ovary(2)	2						GAAGGTCTTTCCATGGCACTG	0.323													G	61466072	G	G	61466072	3	3	229	1	0	0	0	0	1	0	0	0	15542	855	30	5	2600	5	TANC2	17	61466072	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	22444880	61466072	19729138	75	16185											
SERPINB10	5273	broad.mit.edu	37	chr18	61585321	61585321	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgatatatggagagaaaacGtatgcatttcacaatgtaag	10	5	1	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr18:61585321G>A	uc010xev.1	+	4	447	c.357G>A	c.(355-357)ACG>ACA	p.T119T	SERPINB10_uc010xew.1_Silent_p.T119T	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	119						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity	p.T119T(1)		lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				GAGAGAAAACGTATGCATTTC	0.348													A	61585321	A	A	61585321	2	1	229	1	0	0	0	0	0	0	0	1	14097	1132	40	1		1	SERPINB10	18	61585321	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08		61585321	16491927	76	16186											
GZMM	3004	broad.mit.edu	37	chr19	547333	547333	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggaggtgatcccccactcgCgcccgtacatggcctcactg	12	16	1	1	rs148691419	byFrequency	TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr19:547333C>T	uc002low.1	+	2	154	c.109C>T	c.(109-111)CGC>TGC	p.R37C		NM_005317	NP_005308	P51124	GRAM_HUMAN	granzyme M precursor	37	Peptidase S1.				apoptosis|cytolysis|innate immune response|proteolysis	extracellular region	serine-type endopeptidase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCCACTCGCGCCCGTACAT	0.662													T	547333	T	T	547333	3	4	229	1	0	0	0	0	1	0	0	0	6919	768	27	1	115	1	GZMM	19	547333	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08		547333	58581650	77	16187											
FSD1	79187	broad.mit.edu	37	chr19	4323057	4323057	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagcaaggcgttcggcgtgGgcgtggcctaccgcagcctg	16	13	0	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr19:4323057G>A	uc002lzy.2	+	11	1267	c.1114G>A	c.(1114-1116)GGC>AGC	p.G372S	FSD1_uc002lzz.2_Missense_Mutation_p.G372S|FSD1_uc002maa.2_Missense_Mutation_p.G185S	NM_024333	NP_077309	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing	372	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GTTCGGCGTGGGCGTGGCCTA	0.687													A	4323057	A	A	4323057	3	1	229	1	0	0	0	0	1	0	0	0	6070	1232	43	3	1156	3	FSD1	19	4323057	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	3775724	4323057	54805926	78	16188											
KPTN	11133	broad.mit.edu	37	chr19	47979804	47979804	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatacctgcaggatgtgcacGcccttcagggagaccacggc	13	13	1	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr19:47979804G>A	uc002pgy.2	-	11	1271	c.1167C>T	c.(1165-1167)GGC>GGT	p.G389G	KPTN_uc010xys.1_RNA	NM_007059	NP_008990	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	389					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			ovary(1)	1		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		GGATGTGCACGCCCTTCAGGG	0.627													A	47979804	A	A	47979804	2	1	229	1	0	0	0	0	0	0	0	1	8437	1074	38	1		1	KPTN	19	47979804	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08	43656747	47979804	11149179	79	16189											
TNNT1	7138	broad.mit.edu	37	chr19	55645562	55645562	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgatggaggcagccaggCagaccgggccctaggcccag	16	13	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr19:55645562C>G	uc002qjb.3	-	12	711	c.622G>C	c.(622-624)GCC>CCC	p.A208P	TNNT1_uc002qiz.3_Intron|TNNT1_uc002qja.3_Intron|TNNT1_uc002qjc.3_Intron|TNNT1_uc002qje.3_Intron|TNNT1_uc002qjd.3_Intron	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	208					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		GGCAGCCAGGCAGACCGGGCC	0.448													G	55645562	G	G	55645562	3	3	229	1	0	0	0	0	1	0	0	0	16327	710	25	5	226	5	TNNT1	19	55645562	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	7665758	55645562	3483421	80	16190											
KRTAP19-5	337972	broad.mit.edu	37	chr21	31874370	31874370	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatcgaagcctccgtagccGtagcccaggcctccatagta	9	15	1	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr21:31874370G>A	uc011ada.1	-	1	39	c.39C>T	c.(37-39)TAC>TAT	p.Y13Y		NM_181611	NP_853642	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	13						intermediate filament	protein binding				0						CTCCGTAGCCGTAGCCCAGGC	0.572													A	31874370	A	A	31874370	2	1	229	1	0	0	0	0	0	0	0	1	8532	1140	40	1		1	KRTAP19-5	21	31874370	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08		31874370	16255525	81	16191											
KRTAP6-1	337966	broad.mit.edu	37	chr21	31986219	31986219	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtttccgtagtagctgccaCacatggtgttggttgtggag	14	7	0	0	rs146113466		TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr21:31986219C>T	uc002yop.2	-	1	5	c.5G>A	c.(4-6)TGT>TAT	p.C2Y	KRTAP20-1_uc011ade.1_5'Flank	NM_181602	NP_853633	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1	2						cytosol|intermediate filament					0						GTAGCTGCCACACATGGTGTT	0.547													T	31986219	T	T	31986219	3	4	229	1	0	0	0	0	1	0	0	0	8569	478	17	3	214	3	KRTAP6-1	21	31986219	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	111849	31986219	16143676	82	16192											
SBF1	6305	broad.mit.edu	37	chr22	50886843	50886843	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgagcgacggtggtggggtgCggtggacacaaggagggagc	22	7	0	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chr22:50886843C>T	uc003blh.2	-	38	5377	c.5182G>A	c.(5182-5184)GCA>ACA	p.A1728T	SBF1_uc003ble.2_Missense_Mutation_p.A192T|SBF1_uc003blf.2_Missense_Mutation_p.A204T|SBF1_uc011arx.1_Missense_Mutation_p.A1366T	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1702					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		TGGTGGGGTGCGGTGGACACA	0.657													T	50886843	T	T	50886843	3	4	229	1	0	0	0	0	1	0	0	0	13858	768	27	1	515	1	SBF1	22	50886843	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08		50886843	417723	83	16193											
CCNB3	85417	broad.mit.edu	37	chrX	50053319	50053319	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gttggctttgcaggagaaaaGcaccatggaagaagagtccc	13	8	0	3			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:50053319G>T	uc004dox.3	+	6	2448	c.2150G>T	c.(2149-2151)AGC>ATC	p.S717I	CCNB3_uc004doy.2_Missense_Mutation_p.S717I|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	717					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CAGGAGAAAAGCACCATGGAA	0.453													T	50053319	T	T	50053319	3	4	229	1	0	0	0	0	1	0	0	0	2914	971	34	5	2164	5	CCNB3	23	50053319	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08		50053319	105217241	84	16194											
ZC3H12B	340554	broad.mit.edu	37	chrX	64721739	64721739	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaaccaaccccagcgttcGgtggctgatgagctccgcat	11	15	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:64721739G>A	uc010nko.2	+	5	1137	c.1128G>A	c.(1126-1128)TCG>TCA	p.S376S		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	376							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						CCCAGCGTTCGGTGGCTGATG	0.527													A	64721739	A	A	64721739	2	1	229	1	0	0	0	0	0	0	0	1	17559	1103	39	2		2	ZC3H12B	23	64721739	Silent	SNP	G	TCGA-32-2494-01A-01D-1353-08	14668420	64721739	90548821	85	16195											
AWAT2	158835	broad.mit.edu	37	chrX	69263788	69263788	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctactgaccttgagagggaaAtaatcgctgtagtgtttcca	10	8	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:69263788A>G	uc004dxt.1	-	3	261	c.255T>C	c.(253-255)TAT>TAC	p.Y85Y		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	85						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0						TGAGAGGGAAATAATCGCTGT	0.557													G	69263788	G	G	69263788	2	3	229	1	0	0	0	0	0	0	0	1	1235	108	4	4		4	AWAT2	23	69263788	Silent	SNP	A	TCGA-32-2494-01A-01D-1353-08	4542049	69263788	86006772	86	16196											
NONO	4841	broad.mit.edu	37	chrX	70514099	70514099	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aacccgaaccctagcggagaTtgccaaagtggagctggaca	12	11	0	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:70514099T>C	uc004dzo.2	+	6	1081	c.371T>C	c.(370-372)ATT>ACT	p.I124T	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Missense_Mutation_p.I124T|NONO_uc004dzp.2_Missense_Mutation_p.I124T|NONO_uc011mpv.1_Missense_Mutation_p.I35T|NONO_uc004dzq.2_5'UTR	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	124	DBHS.|RRM 1.				DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					CTAGCGGAGATTGCCAAAGTG	0.488			T	TFE3	papillary renal cancer								C	70514099	C	C	70514099	3	2	229	1	0	0	0	0	1	0	0	0	10534	1493	52	4	381	4	NONO	23	70514099	Missense_Mutation	SNP	T	TCGA-32-2494-01A-01D-1353-08	1250311	70514099	84756461	87	16197											
TAF1	6872	broad.mit.edu	37	chrX	70586172	70586172	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttatttccggtctatgggacCcggctgcgatttgctgctgc	12	11	1	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:70586172C>T	uc004dzu.3	+	1	59	c.8C>T	c.(7-9)CCC>CTC	p.P3L	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.P3L	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	3	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				TCTATGGGACCCGGCTGCGAT	0.537													T	70586172	T	T	70586172	3	4	229	1	0	0	0	0	1	0	0	0	15510	623	22	3	10	3	TAF1	23	70586172	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	72073	70586172	84684388	88	16198											
ACTRT1	139741	broad.mit.edu	37	chrX	127185764	127185764	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcatagagcgctgccaccGcatgattagacaggtagaaa	12	9	0	4			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:127185764G>A	uc004eum.2	-	1	619	c.422C>T	c.(421-423)GCG>GTG	p.A141V		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	141						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						CGCTGCCACCGCATGATTAGA	0.522													A	127185764	A	A	127185764	3	1	229	1	0	0	0	0	1	0	0	0	218	1087	38	1	712	1	ACTRT1	23	127185764	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	56599592	127185764	28084796	89	16199											
SLC25A14	9016	broad.mit.edu	37	chrX	129492634	129492634	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attcgaatgcaggctcaaggAagcttgttccaagggagcat	12	8	1	0			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:129492634A>G	uc004evn.1	+	7	732	c.519A>G	c.(517-519)GGA>GGG	p.G173G	SLC25A14_uc011mut.1_Missense_Mutation_p.K110E|SLC25A14_uc011muu.1_Silent_p.G173G|SLC25A14_uc010nrg.2_Silent_p.G170G|SLC25A14_uc004evo.1_5'UTR|SLC25A14_uc004evp.1_Silent_p.G173G|SLC25A14_uc004evq.1_Silent_p.G170G|SLC25A14_uc004evr.1_Silent_p.G170G	NM_003951	NP_003942	O95258	UCP5_HUMAN	solute carrier family 25, member 14 isoform	173	Solcar 2.				aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			ovary(1)	1						AGGCTCAAGGAAGCTTGTTCC	0.353													G	129492634	G	G	129492634	2	3	229	1	0	0	0	0	0	0	0	1	14476	233	9	4		4	SLC25A14	23	129492634	Silent	SNP	A	TCGA-32-2494-01A-01D-1353-08	2306870	129492634	25777926	90	16200											
GPR112	139378	broad.mit.edu	37	chrX	135433699	135433699	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaatgaatttacggaaaattCggtaaaataatcttttgcat	6	4	1	1			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:135433699C>T	uc004ezu.1	+	7	7112	c.6821C>T	c.(6820-6822)TCG>TTG	p.S2274L	GPR112_uc010nsb.1_Missense_Mutation_p.S2069L|GPR112_uc010nsc.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2274	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACGGAAAATTCGGTAAAATAA	0.254													T	135433699	T	T	135433699	3	4	229	1	0	0	0	0	1	0	0	0	6629	898	31	2	6835	2	GPR112	23	135433699	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	5941065	135433699	19836861	91	16201											
ATP11C	286410	broad.mit.edu	37	chrX	138879436	138879436	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tagagtagtgcatactgcagCtttggtcagtaagataaata	10	5	1	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:138879436C>A	uc004faz.2	-	11	1015	c.916G>T	c.(916-918)GCT>TCT	p.A306S	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.A306S	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	306	Helical; (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					CATACTGCAGCTTTGGTCAGT	0.343													A	138879436	A	A	138879436	3	1	229	1	0	0	0	0	1	0	0	0	1121	797	28	5	2625	5	ATP11C	23	138879436	Missense_Mutation	SNP	C	TCGA-32-2494-01A-01D-1353-08	3445737	138879436	16391124	92	16202											
TKTL1	8277	broad.mit.edu	37	chrX	153543586	153543586	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctacgcgaacaacagagtcGttgtgctggatggtgacacc	13	10	0	2			TCGA-32-2494-01A-01D-1353-08	TCGA-32-2494-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	7d45df59-16c5-4706-82ec-6d2f729324ab	6a0d3963-8762-440e-b8f2-757de41b3204	g.chrX:153543586G>A	uc004fkg.2	+	7	1114	c.928G>A	c.(928-930)GTT>ATT	p.V310I	TKTL1_uc011mzl.1_Missense_Mutation_p.V304I|TKTL1_uc011mzm.1_Missense_Mutation_p.V106I|TKTL1_uc004fkh.2_Missense_Mutation_p.V254I	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	310					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAACAGAGTCGTTGTGCTGGA	0.483													A	153543586	A	A	153543586	3	1	229	1	0	0	0	0	1	0	0	0	15932	1145	40	1	954	1	TKTL1	23	153543586	Missense_Mutation	SNP	G	TCGA-32-2494-01A-01D-1353-08	14664150	153543586	1726974	93	16203											
GNB1	2782	broad.mit.edu	37	chr1	1720568	1720568	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gcaaggaggaggcgcccgctCttggagaaggagacagaggt	18	8	1	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:1720568C>A	uc001aif.2	-	10	1172	c.840G>T	c.(838-840)AAG>AAT	p.K280N	GNB1_uc009vky.2_Missense_Mutation_p.K180N	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	280	WD 6.				cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		GGCGCCCGCTCTTGGAGAAGG	0.587											OREG0012998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	1720568	A	A	1720568	3	1	230	1	0	0	0	0	1	0	0	0	6515	912	32	5	190	5	GNB1	1	1720568	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08		1720568	247530053	1	16204											
CHD5	26038	broad.mit.edu	37	chr1	6206730	6206730	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctcccgggcactcacctgtaGctccttcacccaggagcaat	8	17	2	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:6206730G>C	uc001amb.1	-	10	1685	c.1585C>G	c.(1585-1587)CTA>GTA	p.L529V	CHD5_uc001ama.1_5'Flank|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	529	Chromo 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CTCACCTGTAGCTCCTTCACC	0.647													C	6206730	C	C	6206730	3	2	230	1	0	0	0	0	1	0	0	0	3328	962	34	5	4407	5	CHD5	1	6206730	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	4486162	6206730	243043891	2	16205											
CLCNKB	1188	broad.mit.edu	37	chr1	16377396	16377396	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgaagcagcatctggactcGctgttcgacaaccactcctg	9	13	1	1	rs140705060		TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:16377396G>A	uc001axw.3	+	12	1160	c.1080G>A	c.(1078-1080)TCG>TCA	p.S360S	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.S360S|CLCNKB_uc001axy.3_Silent_p.S191S	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	360					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTGGACTCGCTGTTCGACA	0.667													A	16377396	A	A	16377396	2	1	230	1	0	0	0	0	0	0	0	1	3470	1074	38	1		1	CLCNKB	1	16377396	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08	10170666	16377396	232873225	3	16206											
PTAFR	5724	broad.mit.edu	37	chr1	28477001	28477001	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gactggcacgctgcccttctCgtaatgctcaaagcagcgag	11	13	2	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:28477001C>T	uc001bpl.2	-	2	659	c.532G>A	c.(532-534)GAG>AAG	p.E178K	PTAFR_uc001bpm.3_Missense_Mutation_p.E178K|PTAFR_uc009vte.2_Missense_Mutation_p.E178K	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	178	Extracellular (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCCCTTCTCGTAATGCTCA	0.542													T	28477001	T	T	28477001	3	4	230	1	0	0	0	0	1	0	0	0	12723	893	31	2	500	2	PTAFR	1	28477001	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	12099605	28477001	220773620	4	16207											
SLC44A5	204962	broad.mit.edu	37	chr1	75708695	75708695	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgggcacttggagacacagAtctgtgaacgaacaaagtga	12	8	1	4	rs148670291		TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:75708695A>G	uc001dgu.2	-	8	491	c.347T>C	c.(346-348)ATC>ACC	p.I116T	SLC44A5_uc001dgt.2_Missense_Mutation_p.I116T|SLC44A5_uc001dgs.2_Missense_Mutation_p.I74T|SLC44A5_uc001dgr.2_Missense_Mutation_p.I74T|SLC44A5_uc010oqz.1_Missense_Mutation_p.I155T|SLC44A5_uc010ora.1_Missense_Mutation_p.I110T|SLC44A5_uc010orb.1_5'UTR	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	116	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						GGAGACACAGATCTGTGAACG	0.383													G	75708695	G	G	75708695	3	3	230	1	0	0	0	0	1	0	0	0	14639	347	12	4	1991	4	SLC44A5	1	75708695	Missense_Mutation	SNP	A	TCGA-32-2495-01A-01D-1353-08	47231694	75708695	173541926	5	16208											
LRRC8C	84230	broad.mit.edu	37	chr1	90179098	90179098	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaaaactgtccttttgctaTctgtgctttgttagtatcta	6	8	3	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:90179098T>C	uc001dnl.3	+	3	1211	c.969T>C	c.(967-969)TAT>TAC	p.Y323Y		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	323	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		CCTTTTGCTATCTGTGCTTTG	0.408													C	90179098	C	C	90179098	2	2	230	1	0	0	0	0	0	0	0	1	9023	1442	50	4		4	LRRC8C	1	90179098	Silent	SNP	T	TCGA-32-2495-01A-01D-1353-08	14470403	90179098	159071523	6	16209											
ABCA4	24	broad.mit.edu	37	chr1	94508933	94508933	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattccgcttgtggtggaggCctgtgtcctccaacatggct	12	12	0	0	rs61750062		TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:94508933C>T	uc001dqh.2	-	21	3253	c.3149G>A	c.(3148-3150)GGC>GAC	p.G1050D		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1050	Cytoplasmic.|ABC transporter 1.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GTGGTGGAGGCCTGTGTCCTC	0.582													T	94508933	T	T	94508933	3	4	230	1	0	0	0	0	1	0	0	0	34	739	26	3	3792	3	ABCA4	1	94508933	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	4329835	94508933	154741688	7	16210											
POU2F1	5451	broad.mit.edu	37	chr1	167353107	167353107	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctacaggtctcctgcaagcGcaaaatcttctaacgcaact	6	13	4	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:167353107G>A	uc001gec.2	+	9	825	c.663G>A	c.(661-663)GCG>GCA	p.A221A	POU2F1_uc010plg.1_RNA|POU2F1_uc001ged.2_Silent_p.A219A|POU2F1_uc001gee.2_Silent_p.A221A|POU2F1_uc010plh.1_Silent_p.A158A|POU2F1_uc001gef.2_Silent_p.A233A|POU2F1_uc001geg.2_Silent_p.A119A	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	221					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						TCCTGCAAGCGCAAAATCTTC	0.438													A	167353107	A	A	167353107	2	1	230	1	0	0	0	0	0	0	0	1	12271	1074	38	1		1	POU2F1	1	167353107	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08	72844174	167353107	81897514	8	16211											
IVNS1ABP	10625	broad.mit.edu	37	chr1	185267320	185267320	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gcattgctccttggtgaagtCatatttcccatcatcttcca	6	12	3	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:185267320C>T	uc001grl.2	-	15	2399	c.1776G>A	c.(1774-1776)ATG>ATA	p.M592I	IVNS1ABP_uc001gri.2_Missense_Mutation_p.M252I|IVNS1ABP_uc001grj.2_Missense_Mutation_p.M252I|IVNS1ABP_uc009wyj.2_Missense_Mutation_p.M374I|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	592	Kelch 5.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						TTGGTGAAGTCATATTTCCCA	0.423													T	185267320	T	T	185267320	3	4	230	1	0	0	0	0	1	0	0	0	7930	826	29	3	156	3	IVNS1ABP	1	185267320	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	17914213	185267320	63983301	9	16212											
REN	5972	broad.mit.edu	37	chr1	204130489	204130489	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggacgaaccagtgtcaaagaCgactttgaaggtctggggtg	15	7	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:204130489C>T	uc001haq.2	-	3	348	c.304G>A	c.(304-306)GTC>ATC	p.V102I		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	102					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GTGTCAAAGACGACTTTGAAG	0.582													T	204130489	T	T	204130489	3	4	230	1	0	0	0	0	1	0	0	0	13224	536	19	1	948	1	REN	1	204130489	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	18863169	204130489	45120132	10	16213											
HSD11B1	3290	broad.mit.edu	37	chr1	209880164	209880164	+	Frame_Shift_Del	DEL	G	-	-													gcccaagcaggaaagctcatGggtgaggctgtttctcttac							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:209880164delG	uc001hhj.2	+	4	437	c.330delG	c.(328-330)ATGfs	p.M110fs	HSD11B1_uc001hhk.2_Frame_Shift_Del_p.M110fs	NM_181755	NP_861420	P28845	DHI1_HUMAN	11-beta-hydroxysteroid dehydrogenase 1	110	Lumenal (Potential).				glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase (NADP+) activity|11-beta-hydroxysteroid dehydrogenase|binding			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	GAAAGCTCATGGGTGAGGCTG	0.517													-	209880164	-	-	209880164	7	5	230	1	0	1	0	1	0	0	0	0	7375	1362	47	0	340	0	HSD11B1	1	209880164	Frame_Shift_Del	DEL	G	TCGA-32-2495-01A-01D-1353-08	5749675	209880164	39370457	11	16214											
OR2T4	127074	broad.mit.edu	37	chr1	248525116	248525116	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tctggaaatgctgtcctgatCcttctgatacactgtgacgc	9	11	2	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:248525116C>A	uc001ieh.1	+	1	234	c.234C>A	c.(232-234)ATC>ATA	p.I78I		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	78	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGTCCTGATCCTTCTGATAC	0.473													A	248525116	A	A	248525116	2	1	230	1	0	0	0	0	0	0	0	1	11027	845	30	5		5	OR2T4	1	248525116	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	38644952	248525116	725505	12	16215											
OR14I1	401994	broad.mit.edu	37	chr1	248844752	248844752	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctaagactatatatgatgGgattgaggaagggaggcaaa	13	4	0	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr1:248844752G>A	uc001ieu.1	-	1	854	c.854C>T	c.(853-855)CCC>CTC	p.P285L		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATATATGATGGGATTGAGGAA	0.403													A	248844752	A	A	248844752	3	1	230	1	0	0	0	0	1	0	0	0	10947	1232	43	3	85	3	OR14I1	1	248844752	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	319636	248844752	405869	13	16216											
NRXN1	9378	broad.mit.edu	37	chr2	50280492	50280492	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtagtctccataattgatgTggacatctctgattgcatgg	11	7	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr2:50280492T>G	uc010fbp.2	-	4	1657	c.850A>C	c.(850-852)ACA>CCA	p.T284P	NRXN1_uc002rxb.3_Missense_Mutation_p.T1021P|NRXN1_uc010fbq.2_Missense_Mutation_p.T1389P|NRXN1_uc002rxe.3_Missense_Mutation_p.T1319P	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	284	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ATAATTGATGTGGACATCTCT	0.502													G	50280492	G	G	50280492	3	3	230	1	0	0	0	0	1	0	0	0	10665	1696	59	5	490	5	NRXN1	2	50280492	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08		50280492	192918881	14	16217											
LCT	3938	broad.mit.edu	37	chr2	136594490	136594490	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaataccttataatgggtgaTctgactggcatggagactgc	11	7	1	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr2:136594490T>A	uc002tuu.1	-	1	261	c.250A>T	c.(250-252)ATC>TTC	p.I84F		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	84	Extracellular (Potential).				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TAATGGGTGATCTGACTGGCA	0.507													A	136594490	A	A	136594490	3	1	230	1	0	0	0	0	1	0	0	0	8693	1435	50	5	5601	5	LCT	2	136594490	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08	86313998	136594490	106604883	15	16218											
COBLL1	22837	broad.mit.edu	37	chr2	165551199	165551199	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atatccctttctgcctctttAtttgtcagttcttttggagc	6	10	4	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr2:165551199A>T	uc010zcw.1	-	15	3142	c.3018T>A	c.(3016-3018)AAT>AAA	p.N1006K	COBLL1_uc002ucp.2_Missense_Mutation_p.N939K|COBLL1_uc002ucq.2_Missense_Mutation_p.N901K|COBLL1_uc010zcx.1_Missense_Mutation_p.N947K|COBLL1_uc002ucn.2_Missense_Mutation_p.N367K|COBLL1_uc002uco.2_Missense_Mutation_p.N670K	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	977										ovary(2)|pancreas(1)	3						CTGCCTCTTTATTTGTCAGTT	0.468													T	165551199	T	T	165551199	3	4	230	1	0	0	0	0	1	0	0	0	3654	446	16	5	695	5	COBLL1	2	165551199	Missense_Mutation	SNP	A	TCGA-32-2495-01A-01D-1353-08	28956709	165551199	77648174	16	16219											
ZC3H15	55854	broad.mit.edu	37	chr2	187368763	187368763	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatattgtctctataggtgtGcaagcatttcctggaagcta	9	7	1	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr2:187368763G>A	uc002upo.2	+	6	764	c.539G>A	c.(538-540)TGC>TAC	p.C180Y		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	180	C3H1-type 2.					cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			CTATAGGTGTGCAAGCATTTC	0.438													A	187368763	A	A	187368763	3	1	230	1	0	0	0	0	1	0	0	0	17564	1319	46	3	561	3	ZC3H15	2	187368763	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	21817564	187368763	55830610	17	16220											
CCDC150	284992	broad.mit.edu	37	chr2	197521487	197521487	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	actgtgagtttctggtaaatCgaatgtgccgtcttgaaagc	11	7	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr2:197521487C>T	uc002utp.1	+	3	442	c.307C>T	c.(307-309)CGA>TGA	p.R103*	CCDC150_uc002uto.1_Nonsense_Mutation_p.R103*|CCDC150_uc010zgq.1_RNA|CCDC150_uc010zgr.1_Intron|CCDC150_uc010zgs.1_Intron	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	103											0						TCTGGTAAATCGAATGTGCCG	0.398													T	197521487	T	T	197521487	4	4	230	1	0	0	0	0	0	1	0	0	2785	876	31	2	317	2	CCDC150	2	197521487	Nonsense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	10152724	197521487	45677886	18	16221											
NEK10	152110	broad.mit.edu	37	chr3	27233608	27233608	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgtgcgtcttcgttcccgtTctagcttcttttccaaggac	9	12	3	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr3:27233608T>G	uc010hfk.2	-	5	582	c.353A>C	c.(352-354)GAA>GCA	p.E118A	NEK10_uc003cds.1_Missense_Mutation_p.E203A|NEK10_uc010hfj.2_Missense_Mutation_p.E118A			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	806							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TCGTTCCCGTTCTAGCTTCTT	0.423													G	27233608	G	G	27233608	3	3	230	1	0	0	0	0	1	0	0	0	10322	1798	62	5		5	NEK10	3	27233608	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08		27233608	170788822	19	16222											
SLC22A14	9389	broad.mit.edu	37	chr3	38355344	38355344	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cggctgtgctgcatctttctCctccagcagattgggaggaa	12	11	2	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr3:38355344C>G	uc010hhc.1	+	8	1332	c.1290C>G	c.(1288-1290)CTC>CTG	p.L430L	SLC22A14_uc003cib.2_Silent_p.L430L|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	430	Helical; (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GCATCTTTCTCCTCCAGCAGA	0.577													G	38355344	G	G	38355344	2	3	230	1	0	0	0	0	0	0	0	1	14445	842	30	5		5	SLC22A14	3	38355344	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	11121736	38355344	159667086	20	16223											
CDCP1	64866	broad.mit.edu	37	chr3	45153846	45153846	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgctcttatgagctttgacAtcccagatgaaagttctgtt	8	8	2	4			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr3:45153846A>G	uc003com.2	-	3	519	c.384T>C	c.(382-384)GAT>GAC	p.D128D	CDCP1_uc003con.2_Silent_p.D128D	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	128	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		GAGCTTTGACATCCCAGATGA	0.527													G	45153846	G	G	45153846	2	3	230	1	0	0	0	0	0	0	0	1	3093	214	8	4		4	CDCP1	3	45153846	Silent	SNP	A	TCGA-32-2495-01A-01D-1353-08	6798502	45153846	152868584	21	16224											
MYH15	22989	broad.mit.edu	37	chr3	108179152	108179152	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcaattaaaaattactttatGcagagatgcaaccgtttgga	8	6	0	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr3:108179152G>C	uc003dxa.1	-	18	2044	c.1987C>G	c.(1987-1989)CAT>GAT	p.H663D		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	663	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						ATTACTTTATGCAGAGATGCA	0.299													C	108179152	C	C	108179152	3	2	230	1	0	0	0	0	1	0	0	0	10034	1319	46	5	3953	5	MYH15	3	108179152	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	63025306	108179152	89843278	22	16225											
GOLGB1	2804	broad.mit.edu	37	chr3	121413693	121413693	+	Frame_Shift_Del	DEL	G	-	-													cattttggttacttcctcctGaagcatttttagttcaccat							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr3:121413693delG	uc003eei.3	-	13	5788	c.5662delC	c.(5662-5664)CAGfs	p.Q1888fs	GOLGB1_uc010hrc.2_Frame_Shift_Del_p.Q1893fs|GOLGB1_uc003eej.3_Frame_Shift_Del_p.Q1854fs|GOLGB1_uc011bjm.1_Frame_Shift_Del_p.Q1774fs|GOLGB1_uc010hrd.1_Frame_Shift_Del_p.Q1852fs	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1888	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		ACTTCCTCCTGAAGCATTTTT	0.368													-	121413693	-	-	121413693	7	5	230	1	0	1	0	1	0	0	0	0	6565	1299	45	0	4157	0	GOLGB1	3	121413693	Frame_Shift_Del	DEL	G	TCGA-32-2495-01A-01D-1353-08	13234541	121413693	76608737	23	16226											
DIRC2	84925	broad.mit.edu	37	chr3	122514299	122514299	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggcctacggcttctccaGctgggacatcgcgctgctcg	12	16	1	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr3:122514299G>A	uc003efw.3	+	1	399	c.260G>A	c.(259-261)AGC>AAC	p.S87N	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_5'UTR|HSPBAP1_uc003efu.1_5'Flank|HSPBAP1_uc003efv.1_5'Flank	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	87					transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		GGCTTCTCCAGCTGGGACATC	0.662													A	122514299	A	A	122514299	3	1	230	1	0	0	0	0	1	0	0	0	4534	971	34	3	262	3	DIRC2	3	122514299	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	1100606	122514299	75508131	24	16227											
SELT	51714	broad.mit.edu	37	chr3	150321196	150321196	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcggcgtctgcgatggtccGgagcgaggcctcggccaatc	17	13	1	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr3:150321196G>A	uc011bnx.1	+	1	131	c.47G>A	c.(46-48)CGG>CAG	p.R16Q	SERP1_uc003exz.2_5'Flank|uc003eye.1_5'Flank	NM_016275	NP_057359	P62341	SELT_HUMAN	selenoprotein T precursor	16				RSE -> WSD (in Ref. 4; AAH09611).	cell redox homeostasis|selenocysteine incorporation		selenium binding				0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GCGATGGTCCGGAGCGAGGCC	0.597													A	150321196	A	A	150321196	3	1	230	1	0	0	0	0	1	0	0	0	14022	1116	39	2	49	2	SELT	3	150321196	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	27806897	150321196	47701234	25	16228											
PIK3CA	5290	broad.mit.edu	37	chr3	178916614	178916614	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acttgcaaagaatcagaacaAtgcctccacgaccatcatca	5	13	3	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr3:178916614A>G	uc003fjk.2	+	2	158	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATCAGAACAATGCCTCCACG	0.378		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			G	178916614	G	G	178916614	3	3	230	1	0	0	0	0	1	0	0	0	11913	101	4	4	3	4	PIK3CA	3	178916614	Missense_Mutation	SNP	A	TCGA-32-2495-01A-01D-1353-08	28595418	178916614	19105816	26	16229											
MFSD7	84179	broad.mit.edu	37	chr4	680439	680439	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatggacaggaccaagtccTcagcaatgacgtcagccaca	9	14	2	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr4:680439T>C	uc003gay.2	-	2	233	c.176A>G	c.(175-177)GAG>GGG	p.E59G	MFSD7_uc003gaw.2_5'Flank|MFSD7_uc003gax.2_Missense_Mutation_p.E59G|MFSD7_uc003gaz.2_Intron|MFSD7_uc003gba.2_Missense_Mutation_p.E59G|MFSD7_uc003gbb.1_5'UTR	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	59					transmembrane transport	integral to membrane					0						GACCAAGTCCTCAGCAATGAC	0.622													C	680439	C	C	680439	3	2	230	1	0	0	0	0	1	0	0	0	9537	1551	54	4	1539	4	MFSD7	4	680439	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08		680439	190473837	27	16230											
DRD5	1816	broad.mit.edu	37	chr4	9784960	9784960	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaggagggtcctttcgatcGcatgttccagatctatcaga	12	9	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr4:9784960G>A	uc003gmb.3	+	1	1703	c.1307G>A	c.(1306-1308)CGC>CAC	p.R436H		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	436	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CCTTTCGATCGCATGTTCCAG	0.552													A	9784960	A	A	9784960	3	1	230	1	0	0	0	0	1	0	0	0	4760	1087	38	1	1309	1	DRD5	4	9784960	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	9104521	9784960	181369316	28	16231											
UGT2A1	10941	broad.mit.edu	37	chr4	70513056	70513056	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgatagaatctccaaatggTtgaaggagatggtctatttt	10	5	2	4			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr4:70513056T>C	uc003hem.3	-	1	370	c.307A>G	c.(307-309)ACC>GCC	p.T103A	UGT2A1_uc011caq.1_Missense_Mutation_p.T103A|UGT2A1_uc010ihu.2_Missense_Mutation_p.T103A|UGT2A1_uc010iht.2_Missense_Mutation_p.T103A	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	103	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						CTCCAAATGGTTGAAGGAGAT	0.408													C	70513056	C	C	70513056	3	2	230	1	0	0	0	0	1	0	0	0	16950	1725	60	4	1300	4	UGT2A1	4	70513056	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08	60728096	70513056	120641220	29	16232											
EGF	1950	broad.mit.edu	37	chr4	110883096	110883096	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagaaggtcccttatgtttcTgtcctgaaggctcagtgctt	10	10	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr4:110883096T>A	uc003hzy.3	+	8	1719	c.1267T>A	c.(1267-1269)TGT>AGT	p.C423S	EGF_uc011cfu.1_Missense_Mutation_p.C381S|EGF_uc011cfv.1_Missense_Mutation_p.C423S	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	423	EGF-like 3.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CTTATGTTTCTGTCCTGAAGG	0.393													A	110883096	A	A	110883096	3	1	230	1	0	0	0	0	1	0	0	0	4962	1580	55	5	1297	5	EGF	4	110883096	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08	40370040	110883096	80271180	30	16233											
PDZD2	23037	broad.mit.edu	37	chr5	32074373	32074381	+	In_Frame_Del	DEL	CCTATGCAG	-	-													gggcatggtggatgctgcgtCctatgcagccaacctcacgg							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr5:32074373_32074381delCCTATGCAG	uc003jhl.2	+	18	3549_3557	c.3161_3169delCCTATGCAG	c.(3160-3171)TCCTATGCAGCC>TCC	p.YAA1055del	PDZD2_uc003jhm.2_In_Frame_Del_p.YAA1055del|PDZD2_uc011cnx.1_In_Frame_Del_p.YAA881del	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1055_1057					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GATGCTGCGTCCTATGCAGCCAACCTCAC	0.569													-	32074381	-	-	32074373	7	5	230	1	0	1	0	1	0	0	0	0	11701	855	30	0	3227	0	PDZD2	5	32074373	In_Frame_Del	DEL	CCTATGCAG	TCGA-32-2495-01A-01D-1353-08		32074373	148840887	31	16234											
ADAMTS12	81792	broad.mit.edu	37	chr5	33751608	33751608	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaccagtggatgcttcttcaCgggttcaatgaaaaagtctc	9	9	4	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr5:33751608C>T	uc003jia.1	-	3	698	c.535G>A	c.(535-537)GTG>ATG	p.V179M	ADAMTS12_uc010iuq.1_Missense_Mutation_p.V179M|ADAMTS12_uc003jib.1_Missense_Mutation_p.V179M	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	179					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGCTTCTTCACGGGTTCAATG	0.423										HNSCC(64;0.19)			T	33751608	T	T	33751608	3	4	230	1	0	0	0	0	1	0	0	0	257	536	19	1	4337	1	ADAMTS12	5	33751608	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	1677235	33751608	147163652	32	16235											
ACSL6	23305	broad.mit.edu	37	chr5	131296260	131296260	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccttcaattcctctcttctGggcccaggagggcataactt	8	13	3	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr5:131296260G>A	uc010jdo.1	-	19	1920	c.1837C>T	c.(1837-1839)CAG>TAG	p.Q613*	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Nonsense_Mutation_p.Q638*|ACSL6_uc003kvy.1_Nonsense_Mutation_p.Q638*|ACSL6_uc003kwb.2_Nonsense_Mutation_p.Q603*|ACSL6_uc003kvz.1_Nonsense_Mutation_p.Q538*|ACSL6_uc003kwa.1_Nonsense_Mutation_p.Q624*|ACSL6_uc003kvw.1_Nonsense_Mutation_p.Q259*|ACSL6_uc010jdn.1_Nonsense_Mutation_p.Q628*	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	613	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTCTCTTCTGGGCCCAGGAG	0.458													A	131296260	A	A	131296260	4	1	230	1	0	0	0	0	0	1	0	0	181	1357	47	3	268	3	ACSL6	5	131296260	Nonsense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	97544652	131296260	49619000	33	16236											
CSF1R	1436	broad.mit.edu	37	chr5	149456956	149456956	+	Frame_Shift_Del	DEL	G	-	-													gttgagggtcaggactttttGgtaacggttattatgaaagt							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr5:149456956delG	uc003lrl.2	-	5	967	c.772delC	c.(772-774)CAAfs	p.Q258fs	CSF1R_uc011dcd.1_Frame_Shift_Del_p.Q110fs|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Frame_Shift_Del_p.Q258fs|CSF1R_uc011dce.1_Frame_Shift_Del_p.Q258fs|CSF1R_uc011dcf.1_Frame_Shift_Del_p.Q258fs	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	258	Extracellular (Potential).|Ig-like C2-type 3.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	AGGACTTTTTGGTAACGGTTA	0.443													-	149456956	-	-	149456956	7	5	230	1	0	1	0	1	0	0	0	0	3932	1357	47	0	2214	0	CSF1R	5	149456956	Frame_Shift_Del	DEL	G	TCGA-32-2495-01A-01D-1353-08	18160696	149456956	31458304	34	16237											
FABP6	2172	broad.mit.edu	37	chr5	159656578	159656578	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcagcatggctttcaccgGcaagttcgagatggagagtg	14	9	1	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr5:159656578G>A	uc003lya.1	+	1	142	c.14G>A	c.(13-15)GGC>GAC	p.G5D	FABP6_uc003lxx.1_Missense_Mutation_p.G54D|FABP6_uc003lxz.1_Missense_Mutation_p.G54D	NM_001445	NP_001436	P51161	FABP6_HUMAN	gastrotropin isoform 2	5					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTTTCACCGGCAAGTTCGAG	0.537													A	159656578	A	A	159656578	3	1	230	1	0	0	0	0	1	0	0	0	5361	1203	42	3	171	3	FABP6	5	159656578	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	10199622	159656578	21258682	35	16238											
PGBD1	84547	broad.mit.edu	37	chr6	28269185	28269186	+	Missense_Mutation	DNP	GT	TA	TA													cacctagatcaaaaagataaGtttacaaagttgagacctct							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr6:28269185_28269186GT>TA	uc003nky.2	+	7	1924_1925	c.1554_1555GT>TA	c.(1552-1557)AAGTTT>AATATT	p.518_519KF>NI	PGBD1_uc003nkz.2_Missense_Mutation_p.518_519KF>NI	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	518_519					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						AAAAAGATAAGTTTACAAAGTT	0.356													TA	28269186	TA	TA	28269185	3	4	230	1	0	0	0	0	1	0	0	0	11780	1020	36	5	1576	5	PGBD1	6	28269185	Missense_Mutation	DNP	GT	TCGA-32-2495-01A-01D-1353-08		28269185	142845882	36	16239											
TRIM10	10107	broad.mit.edu	37	chr6	30126240	30126240	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcaataagagcactaaacCggcagatctccccagcaacc	6	15	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr6:30126240C>T	uc003npo.3	-	3	768	c.692G>A	c.(691-693)CGG>CAG	p.R231Q	TRIM10_uc003npn.2_Missense_Mutation_p.R231Q	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	231						cytoplasm	zinc ion binding				0						AGCACTAAACCGGCAGATCTC	0.542													T	30126240	T	T	30126240	3	4	230	1	0	0	0	0	1	0	0	0	16483	652	23	2	861	2	TRIM10	6	30126240	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	1857055	30126240	140988827	37	16240											
C6orf27	80737	broad.mit.edu	37	chr6	31742303	31742303	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tgtctggtacctggaggtttCgggggatgagttccaaagta	15	6	1	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr6:31742303C>A	uc011dog.1	-	5	949	c.711G>T	c.(709-711)CCG>CCT	p.P237P	C6orf27_uc003nxd.2_5'UTR|C6orf27_uc011doh.1_RNA	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	237						extracellular region				ovary(3)	3						CTGGAGGTTTCGGGGGATGAG	0.542													A	31742303	A	A	31742303	2	1	230	1	0	0	0	0	0	0	0	1	2362	871	31	5		5	C6orf27	6	31742303	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	1616063	31742303	139372764	38	16241											
TAP2	6891	broad.mit.edu	37	chr6	32797852	32797852	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaacagcacaggctcctgCccaactgaaaccacctgtgc	9	15	0	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr6:32797852C>T	uc003occ.2	-	9	1681	c.1650G>A	c.(1648-1650)GGG>GGA	p.G550G	TAP2_uc011dqf.1_Silent_p.G550G|TAP2_uc003ocb.1_Silent_p.G550G|TAP2_uc003ocd.2_Silent_p.G550G	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	550	ABC transporter.|Cytoplasmic (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						CAGGCTCCTGCCCAACTGAAA	0.587													T	32797852	T	T	32797852	2	4	230	1	0	0	0	0	0	0	0	1	15548	726	26	3		3	TAP2	6	32797852	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	1055549	32797852	138317215	39	16242											
CRISP3	10321	broad.mit.edu	37	chr6	49700907	49700907	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgctaaaatatatacttaCgcaggacaatattggcaaac	6	8	0	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr6:49700907C>T	uc003ozs.2	-	6	536	c.521_splice	c.e6+1	p.A174_splice		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor						innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TATATACTTACGCAGGACAAT	0.299													T	49700907	T	T	49700907	5	4	230	1	0	0	0	0	0	0	1	0	3881	550	19	1	227	1	CRISP3	6	49700907	Splice_Site	SNP	C	TCGA-32-2495-01A-01D-1353-08	16903055	49700907	121414160	40	16243											
NT5E	4907	broad.mit.edu	37	chr6	86203692	86203692	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctttaatatttctttcactTtgggcagtgatctttgtttt	6	6	4	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr6:86203692T>C	uc003pko.3	+	9	2251	c.1695T>C	c.(1693-1695)CTT>CTC	p.L565L	NT5E_uc010kbr.2_Silent_p.L515L	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	565					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	TTCTTTCACTTTGGGCAGTGA	0.358													C	86203692	C	C	86203692	2	2	230	1	0	0	0	0	0	0	0	1	10693	1828	64	4		4	NT5E	6	86203692	Silent	SNP	T	TCGA-32-2495-01A-01D-1353-08	36502785	86203692	84911375	41	16244											
MAP3K5	4217	broad.mit.edu	37	chr6	137041637	137041637	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatcacagtagaggatgatgTtgttggccatgctgaaactt	11	6	1	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr6:137041637T>C	uc003qhc.2	-	2	900	c.539A>G	c.(538-540)AAC>AGC	p.N180S	MAP3K5_uc011edk.1_Missense_Mutation_p.N25S|MAP3K5_uc010kgw.1_Missense_Mutation_p.N180S	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	180					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GAGGATGATGTTGTTGGCCAT	0.473													C	137041637	C	C	137041637	3	2	230	1	0	0	0	0	1	0	0	0	9253	1725	60	4	3701	4	MAP3K5	6	137041637	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08	50837945	137041637	34073430	42	16245											
GLI3	2737	broad.mit.edu	37	chr7	42005081	42005081	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggttctgcgggtggacgaccAtgccgttgcagaacccaaag	14	11	1	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr7:42005081A>G	uc011kbh.1	-	15	3681	c.3590T>C	c.(3589-3591)ATG>ACG	p.M1197T	GLI3_uc011kbg.1_Missense_Mutation_p.M1138T	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1197					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GTGGACGACCATGCCGTTGCA	0.662									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				G	42005081	G	G	42005081	3	3	230	1	0	0	0	0	1	0	0	0	6439	217	8	4	1156	4	GLI3	7	42005081	Missense_Mutation	SNP	A	TCGA-32-2495-01A-01D-1353-08		42005081	117133582	43	16246											
LMTK2	22853	broad.mit.edu	37	chr7	97822800	97822800	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcagtggatgtccacgaagCgctactggactctttaggat	12	9	2	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr7:97822800C>T	uc003upd.1	+	11	3316	c.3023C>T	c.(3022-3024)GCG>GTG	p.A1008V		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	1008					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					GTCCACGAAGCGCTACTGGAC	0.587													T	97822800	T	T	97822800	3	4	230	1	0	0	0	0	1	0	0	0	8859	768	27	1	3065	1	LMTK2	7	97822800	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	55817719	97822800	61315863	44	16247											
LAMB1	3912	broad.mit.edu	37	chr7	107566693	107566693	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttcaatatattctgcctcccCggagttttgggcagctttcc	8	12	2	0	rs143093758		TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr7:107566693C>A	uc003vew.2	-	32	5334	c.4999G>T	c.(4999-5001)GGG>TGG	p.G1667W	LAMB1_uc003vev.2_Missense_Mutation_p.G1691W|LAMB1_uc003veu.2_Missense_Mutation_p.G150W	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1667	Potential.|Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTGCCTCCCCGGAGTTTTGG	0.428													A	107566693	A	A	107566693	3	1	230	1	0	0	0	0	1	0	0	0	8610	652	23	5	373	5	LAMB1	7	107566693	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	9743893	107566693	51571970	45	16248											
LAMB4	22798	broad.mit.edu	37	chr7	107703420	107703420	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactccatgggactcacgccGgaagcatggcaggagcatcc	12	14	1	0	rs144037364	byFrequency	TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr7:107703420G>A	uc010ljo.1	-	23	3165	c.3081C>T	c.(3079-3081)TCC>TCT	p.S1027S	LAMB4_uc003vey.2_Silent_p.S1027S|LAMB4_uc010ljp.1_5'UTR	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1027	Laminin EGF-like 11.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						GACTCACGCCGGAAGCATGGC	0.517													A	107703420	A	A	107703420	2	1	230	1	0	0	0	0	0	0	0	1	8613	1103	39	2		2	LAMB4	7	107703420	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08	136727	107703420	51435243	46	16249											
MET	4233	broad.mit.edu	37	chr7	116340174	116340174	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgacattcttttcggggtgTtcgcacaaagcaagccagat	10	9	1	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr7:116340174T>C	uc003vij.2	+	2	1223	c.1036T>C	c.(1036-1038)TTC>CTC	p.F346L	MET_uc010lkh.2_Missense_Mutation_p.F346L|MET_uc011knc.1_Missense_Mutation_p.F346L|MET_uc011knd.1_Missense_Mutation_p.F346L|MET_uc011kne.1_Missense_Mutation_p.F346L|MET_uc011knf.1_Missense_Mutation_p.F346L|MET_uc011kng.1_Missense_Mutation_p.F346L|MET_uc011knh.1_Missense_Mutation_p.F346L|MET_uc011kni.1_Missense_Mutation_p.F346L|MET_uc003vii.1_Missense_Mutation_p.F365L|MET_uc010lkg.2_Missense_Mutation_p.F346L|MET_uc011kmz.1_Missense_Mutation_p.F346L|MET_uc011kna.1_Missense_Mutation_p.F346L|MET_uc011knb.1_Missense_Mutation_p.F346L	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	346	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTTCGGGGTGTTCGCACAAAG	0.468			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				C	116340174	C	C	116340174	3	2	230	1	0	0	0	0	1	0	0	0	9485	1725	60	4	1038	4	MET	7	116340174	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08	8636754	116340174	42798489	47	16250											
MET	4233	broad.mit.edu	37	chr7	116340270	116340270	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgacttcttcaacaagatcGtcaacaaaaacaatgtgaga	6	9	3	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr7:116340270G>A	uc003vij.2	+	2	1319	c.1132G>A	c.(1132-1134)GTC>ATC	p.V378I	MET_uc010lkh.2_Missense_Mutation_p.V378I|MET_uc011knc.1_Missense_Mutation_p.V378I|MET_uc011knd.1_Missense_Mutation_p.V378I|MET_uc011kne.1_Missense_Mutation_p.V378I|MET_uc011knf.1_Missense_Mutation_p.V378I|MET_uc011kng.1_Missense_Mutation_p.V378I|MET_uc011knh.1_Missense_Mutation_p.V378I|MET_uc011kni.1_Missense_Mutation_p.V378I|MET_uc003vii.1_Missense_Mutation_p.V397I|MET_uc010lkg.2_Missense_Mutation_p.V378I|MET_uc011kmz.1_Missense_Mutation_p.V378I|MET_uc011kna.1_Missense_Mutation_p.V378I|MET_uc011knb.1_Missense_Mutation_p.V378I	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	378	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CAACAAGATCGTCAACAAAAA	0.433			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				A	116340270	A	A	116340270	3	1	230	1	0	0	0	0	1	0	0	0	9485	1145	40	1	1134	1	MET	7	116340270	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	96	116340270	42798393	48	16251											
KCNH2	3757	broad.mit.edu	37	chr7	150645539	150645539	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccccgcctcacccttgtcCgtgcgcctgcggaaggacaa	10	18	1	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr7:150645539C>T	uc003wic.2	-	11	2698	c.2685G>A	c.(2683-2685)ACG>ACA	p.T895T	KCNH2_uc003wib.2_Silent_p.T555T|KCNH2_uc011kux.1_Silent_p.T799T	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	895	Cytoplasmic (Potential).			T->A: Abolishes phosphorylation; when associated with A-283; A-890 and A-1137.	blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	cacccTTGTCCGTGCGCCTGC	0.368													T	150645539	T	T	150645539	2	4	230	1	0	0	0	0	0	0	0	1	8032	639	23	2		2	KCNH2	7	150645539	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	34305269	150645539	8493124	49	16252											
NEFM	4741	broad.mit.edu	37	chr8	24775127	24775127	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgaagctaaagaggaaaagAaagtggaggaaaagagtgag	15	3	0	4			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr8:24775127A>G	uc003xed.3	+	3	1792	c.1759A>G	c.(1759-1761)AAA>GAA	p.K587E	NEFM_uc011lac.1_Missense_Mutation_p.K587E|NEFM_uc010lue.2_Missense_Mutation_p.K211E	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	587	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		agaggaaaagaaagtggagga	0.249													G	24775127	G	G	24775127	3	3	230	1	0	0	0	0	1	0	0	0	10316	247	9	4	1769	4	NEFM	8	24775127	Missense_Mutation	SNP	A	TCGA-32-2495-01A-01D-1353-08		24775127	121588895	50	16253											
UBR5	51366	broad.mit.edu	37	chr8	103297923	103297923	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggcgttgctagcttccaaagCagctgctgcagctgcagcac	12	13	0	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr8:103297923C>G	uc003ykr.1	-	39	5335	c.5302G>C	c.(5302-5304)GCT>CCT	p.A1768P	UBR5_uc003yks.1_Missense_Mutation_p.A1768P	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1768	Poly-Ala.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GCTTCCAAAGCAGCTGCTGCA	0.468													G	103297923	G	G	103297923	3	3	230	1	0	0	0	0	1	0	0	0	16902	710	25	5	3181	5	UBR5	8	103297923	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	78522796	103297923	43066099	51	16254											
CSMD3	114788	broad.mit.edu	37	chr8	113420584	113420584	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatcccttagctgttattggTccaactgaagtaaatcgaat	7	8	0	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr8:113420584T>C	uc003ynu.2	-	34	5727	c.5568A>G	c.(5566-5568)GGA>GGG	p.G1856G	CSMD3_uc003yns.2_Intron|CSMD3_uc003ynt.2_Silent_p.G1816G|CSMD3_uc011lhx.1_Silent_p.G1752G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1856	Extracellular (Potential).|CUB 10.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTGTTATTGGTCCAACTGAAG	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			C	113420584	C	C	113420584	2	2	230	1	0	0	0	0	0	0	0	1	3946	1654	58	4		4	CSMD3	8	113420584	Silent	SNP	T	TCGA-32-2495-01A-01D-1353-08	10122661	113420584	32943438	52	16255											
BICD2	23299	broad.mit.edu	37	chr9	95480999	95480999	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccgtggtgcggtccacggctGcctgcaggtgcttgatctgg	16	12	1	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr9:95480999G>T	uc004aso.1	-	5	1985	c.1928C>A	c.(1927-1929)GCA>GAA	p.A643E	BICD2_uc004asp.1_Missense_Mutation_p.A643E	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	643					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						GTCCACGGCTGCCTGCAGGTG	0.622													T	95480999	T	T	95480999	3	4	230	1	0	0	0	0	1	0	0	0	1429	1319	46	5	661	5	BICD2	9	95480999	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08		95480999	45732432	53	16256											
ANKRD30A	91074	broad.mit.edu	37	chr10	37486209	37486209	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaatctcttttgctttttagAgcctcccgagaagccatctg	7	11	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr10:37486209A>G	uc001iza.1	+	28	2546	c.2447A>G	c.(2446-2448)GAG>GGG	p.E816G		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	872						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						TGCTTTTTAGAGCCTCCCGAG	0.338													G	37486209	G	G	37486209	3	3	230	1	0	0	0	0	1	0	0	0	658	318	11	4	2557	4	ANKRD30A	10	37486209	Missense_Mutation	SNP	A	TCGA-32-2495-01A-01D-1353-08		37486209	98048538	54	16257											
ARID5B	84159	broad.mit.edu	37	chr10	63816874	63816874	+	Splice_Site	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggtatattttcccttttccAggtgaaatgtgaggccaggt	11	7	0	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr10:63816874A>C	uc001jlt.1	+	6	873	c.847_splice	c.e6-2	p.V283_splice	ARID5B_uc001jlu.1_Splice_Site_p.V40_splice	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)						liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					TCCCTTTTCCAGGTGAAATGT	0.448													C	63816874	C	C	63816874	5	2	230	1	0	0	0	0	0	0	1	0	922	202	7	5	867	5	ARID5B	10	63816874	Splice_Site	SNP	A	TCGA-32-2495-01A-01D-1353-08	26330665	63816874	71717873	55	16258											
PTEN	5728	broad.mit.edu	37	chr10	89717664	89717664	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gatatattcctccaattcagGacccacacgacgggaagaca	8	12	1	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr10:89717664G>A	uc001kfb.2	+	8	1720	c.689G>A	c.(688-690)GGA>GAA	p.G230E		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	230	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.P231fs*12(1)|p.G230fs*26(1)|p.G165_*404del(1)|p.?(1)|p.G165_K342del(1)|p.G230E(1)|p.G230R(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TCCAATTCAGGACCCACACGA	0.428		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89717664	A	A	89717664	3	1	230	1	0	0	0	0	1	0	0	0	12738	1174	41	3	715	3	PTEN	10	89717664	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	25900790	89717664	45817083	56	16259											
PDCD4	27250	broad.mit.edu	37	chr10	112655708	112655708	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtaatttcattgttgtagggTtatgagagaatttacaatga	10	2	1	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr10:112655708T>C	uc001kzh.2	+	11	1455	c.1212T>C	c.(1210-1212)GGT>GGC	p.G404G	PDCD4_uc001kzg.2_Silent_p.G393G|PDCD4_uc010qre.1_Silent_p.G390G	NM_014456	NP_055271	Q53EL6	PDCD4_HUMAN	programmed cell death 4 isoform 1	404	MI 2.				apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TGTTGTAGGGTTATGAGAGAA	0.353													C	112655708	C	C	112655708	2	2	230	1	0	0	0	0	0	0	0	1	11621	1712	60	4		4	PDCD4	10	112655708	Silent	SNP	T	TCGA-32-2495-01A-01D-1353-08	22938044	112655708	22879039	57	16260											
USP47	55031	broad.mit.edu	37	chr11	11969542	11969542	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctggcagctttcaaacaaCatttagagccctttgttgga	8	10	2	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr11:11969542C>T	uc001mjs.2	+	21	3905	c.3142C>T	c.(3142-3144)CAT>TAT	p.H1048Y	USP47_uc001mjr.2_Missense_Mutation_p.H980Y|USP47_uc009ygi.2_5'Flank	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1068					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TTTCAAACAACATTTAGAGCC	0.398													T	11969542	T	T	11969542	3	4	230	1	0	0	0	0	1	0	0	0	17075	478	17	3	3016	3	USP47	11	11969542	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08		11969542	123036974	58	16261											
RTN3	10313	broad.mit.edu	37	chr11	63487657	63487657	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgaagaattggtcagtgaCtctgagctgcatcaagatca	10	7	4	5			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr11:63487657C>T	uc001nxq.2	+	3	1870	c.1683C>T	c.(1681-1683)GAC>GAT	p.D561D	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Silent_p.D542D|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Silent_p.D449D|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	561					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						TGGTCAGTGACTCTGAGCTGC	0.408													T	63487657	T	T	63487657	2	4	230	1	0	0	0	0	0	0	0	1	13727	564	20	3		3	RTN3	11	63487657	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	51518115	63487657	71518859	59	16262											
SLC22A20	440044	broad.mit.edu	37	chr11	64990066	64990067	+	Missense_Mutation	DNP	AG	GT	GT													aggggaaaggctgaccaaggAggtaagcgagctgggaggaa							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr11:64990066_64990067AG>GT	uc010roc.1	+	6	929_930	c.926_927AG>GT	c.(925-927)GAG>GGT	p.E309G	SLC22A20_uc010rob.1_Missense_Mutation_p.G253C	NM_001004326	NP_001004326	A6NK97	S22AK_HUMAN	solute carrier family 22, member 20	309	Cytoplasmic (Potential).				ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)	1						CTGACCAAGGAGGTAAGCGAGC	0.545													GT	64990067	GT	GT	64990066	3	3	230	1	0	0	0	0	1	0	0	0	14451	318	11	4	776	4	SLC22A20	11	64990066	Missense_Mutation	DNP	AG	TCGA-32-2495-01A-01D-1353-08	1502409	64990066	70016450	60	16263											
CDC42EP2	10435	broad.mit.edu	37	chr11	65088799	65088799	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cccctcagccttccccacagGagggagggagtgtggacatc	13	14	1	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr11:65088799G>T	uc001odl.2	+	2	880	c.430G>T	c.(430-432)GAG>TAG	p.E144*		NM_006779	NP_006770	O14613	BORG1_HUMAN	Cdc42 effector protein 2	144					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity				0						TTCCCCACAGGAGGGAGGGAG	0.667													T	65088799	T	T	65088799	4	4	230	1	0	0	0	0	0	1	0	0	3076	1175	41	5	432	5	CDC42EP2	11	65088799	Nonsense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	98733	65088799	69917717	61	16264											
C1S	716	broad.mit.edu	37	chr12	7177423	7177423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagcatgtgtttattcatcCgggatggaagctgctggaag	14	6	1	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr12:7177423C>T	uc001qsj.2	+	15	2254	c.1535C>T	c.(1534-1536)CCG>CTG	p.P512L	C1S_uc001qsk.2_Missense_Mutation_p.P512L|C1S_uc001qsl.2_Missense_Mutation_p.P512L|C1S_uc009zfr.2_Missense_Mutation_p.P345L|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	512	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TTTATTCATCCGGGATGGAAG	0.512													T	7177423	T	T	7177423	3	4	230	1	0	0	0	0	1	0	0	0	1974	652	23	2	1577	2	C1S	12	7177423	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08		7177423	126674472	62	16265											
C12orf63	374467	broad.mit.edu	37	chr12	97087506	97087506	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttctcctgataggttctgCctctccttgcattgtatcaa	6	11	4	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr12:97087506C>T	uc001tet.1	+	12	1624	c.1546C>T	c.(1546-1548)CCT>TCT	p.P516S		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	516										skin(6)|ovary(1)	7						ATAGGTTCTGCCTCTCCTTGC	0.289													T	97087506	T	T	97087506	3	4	230	1	0	0	0	0	1	0	0	0	1706	739	26	3	1588	3	C12orf63	12	97087506	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	89910083	97087506	36764389	63	16266											
SELPLG	6404	broad.mit.edu	37	chr12	109017719	109017719	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggctgctggttgagtggtcTgtatctccatagctgctgaa	13	8	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr12:109017719T>C	uc001tni.2	-	2	525	c.365A>G	c.(364-366)CAG>CGG	p.Q122R	SELPLG_uc001tnh.2_Missense_Mutation_p.Q122R|SELPLG_uc010sxe.1_Missense_Mutation_p.Q138R	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	122	1.|Extracellular (Potential).|12 X 10 AA tandem repeats.				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						TTGAGTGGTCTGTATCTCCAT	0.602													C	109017719	C	C	109017719	3	2	230	1	0	0	0	0	1	0	0	0	14020	1580	55	4	851	4	SELPLG	12	109017719	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08	11930213	109017719	24834176	64	16267											
TPCN1	53373	broad.mit.edu	37	chr12	113729743	113729743	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttccgaatgaactacagccGcaagaaccaggactcggaag	10	12	0	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr12:113729743G>A	uc001tuw.2	+	25	2390	c.2093G>A	c.(2092-2094)CGC>CAC	p.R698H	TPCN1_uc001tux.2_Missense_Mutation_p.R770H|TPCN1_uc010syu.1_5'Flank	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	698	Cytoplasmic (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						AACTACAGCCGCAAGAACCAG	0.498													A	113729743	A	A	113729743	3	1	230	1	0	0	0	0	1	0	0	0	16392	1087	38	1	2407	1	TPCN1	12	113729743	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	4712024	113729743	20122152	65	16268											
KSR2	283455	broad.mit.edu	37	chr12	118198974	118198974	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcttcttcctcatgggcggCgtgcccggcggggtcacggt	15	13	4	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr12:118198974C>T	uc001two.2	-	4	796	c.741G>A	c.(739-741)ACG>ACA	p.T247T		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	276	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCATGGGCGGCGTGCCCGGCG	0.706													T	118198974	T	T	118198974	2	4	230	1	0	0	0	0	0	0	0	1	8582	755	27	1		1	KSR2	12	118198974	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	4469231	118198974	15652921	66	16269											
CLIP1	6249	broad.mit.edu	37	chr12	122803873	122803873	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgttccattatctgcatgGcatcttccgctgtttgagca	8	11	3	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr12:122803873G>A	uc001ucg.1	-	17	3378	c.3272C>T	c.(3271-3273)GCC>GTC	p.A1091V	CLIP1_uc001uch.1_Missense_Mutation_p.A1080V|CLIP1_uc001uci.1_Missense_Mutation_p.A1045V|CLIP1_uc001ucj.1_Missense_Mutation_p.A666V	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1091	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TATCTGCATGGCATCTTCCGC	0.478													A	122803873	A	A	122803873	3	1	230	1	0	0	0	0	1	0	0	0	3532	1203	42	3	1080	3	CLIP1	12	122803873	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	4604899	122803873	11048022	67	16270											
EP400	57634	broad.mit.edu	37	chr12	132527862	132527862	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcctcaggccctcaagagtaTtgagtatctggaggaggatg	13	8	3	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr12:132527862T>A	uc001ujn.2	+	32	6256	c.6221T>A	c.(6220-6222)ATT>AAT	p.I2074N	EP400_uc001ujl.2_Missense_Mutation_p.I2073N|EP400_uc001ujm.2_Missense_Mutation_p.I1993N	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2110					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CTCAAGAGTATTGAGTATCTG	0.463													A	132527862	A	A	132527862	3	1	230	1	0	0	0	0	1	0	0	0	5149	1493	52	5	6344	5	EP400	12	132527862	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08	9723989	132527862	1324033	68	16271											
SLC15A1	6564	broad.mit.edu	37	chr13	99356577	99356577	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggggcccacactagaagcGtgtggcgttggccctgcttg	16	11	0	1	rs141206459		TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr13:99356577G>A	uc001vno.2	-	17	1459	c.1382C>T	c.(1381-1383)ACG>ATG	p.T461M		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	461	Extracellular (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CACTAGAAGCGTGTGGCGTTG	0.453													A	99356577	A	A	99356577	3	1	230	1	0	0	0	0	1	0	0	0	14398	1145	40	1	772	1	SLC15A1	13	99356577	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08		99356577	15813301	69	16272											
OR11H12	440153	broad.mit.edu	37	chr14	19378103	19378103	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgggtttgtggatttctgtgGttcctgatccccattgttct	11	8	2	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr14:19378103G>T	uc010tkp.1	+	1	510	c.510G>T	c.(508-510)TGG>TGT	p.W170C		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	170	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GATTTCTGTGGTTCCTGATCC	0.483													T	19378103	T	T	19378103	3	4	230	1	0	0	0	0	1	0	0	0	10927	1270	44	5	512	5	OR11H12	14	19378103	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08		19378103	87971437	70	16273											
OR4Q3	441669	broad.mit.edu	37	chr14	20216022	20216022	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cccagctatgcctttggttgGttcttgcctgctggtgtggg	14	10	1	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr14:20216022G>T	uc010tkt.1	+	1	436	c.436G>T	c.(436-438)GTT>TTT	p.V146F		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCTTTGGTTGGTTCTTGCCTG	0.488													T	20216022	T	T	20216022	3	4	230	1	0	0	0	0	1	0	0	0	11081	1261	44	5	438	5	OR4Q3	14	20216022	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	837919	20216022	87133518	71	16274											
PABPN1	8106	broad.mit.edu	37	chr14	23777257	23777258	+	Frame_Shift_Ins	INS	-	C	C													caagggggccccaactggggINSccgccttgtagccttctttg							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr14:23777257_23777258insC	uc001wjh.3	+	3	469_470	c.281_282insC	c.(280-282)GGCfs	p.G94fs	BCL2L2_uc001wjg.3_Frame_Shift_Ins_p.G94fs|BCL2L2_uc001wji.3_Frame_Shift_Ins_p.G94fs	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	Error:Variant_position_missing_in_Q86U42_after_alignment					modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CCCAACTGGGGCCGCCTTGTAG	0.574													C	23777258	C	C	23777257	7	5	230	1	0	1	1	0	0	0	0	0	11368	1203	42	0		0	PABPN1	14	23777257	Frame_Shift_Ins	INS	-	TCGA-32-2495-01A-01D-1353-08	3561235	23777257	83572283	72	16275											
KHNYN	23351	broad.mit.edu	37	chr14	24901649	24901649	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aagcagcagggcatggcacgGggtcgggggcctcaatggaa	18	9	1	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr14:24901649G>C	uc001wph.3	+	3	1384	c.1182G>C	c.(1180-1182)CGG>CGC	p.R394R	KHNYN_uc010tpc.1_Silent_p.R435R|KHNYN_uc010alw.2_Silent_p.R394R|CBLN3_uc001wpg.3_5'Flank	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	394										ovary(2)|liver(1)	3						GCATGGCACGGGGTCGGGGGC	0.667											OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	24901649	C	C	24901649	2	2	230	1	0	0	0	0	0	0	0	1	8150	1219	43	5		5	KHNYN	14	24901649	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08	1124392	24901649	82447891	73	16276											
MARK3	4140	broad.mit.edu	37	chr14	103933475	103933475	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagaatctcttagtaagatgAaatacgatgaaatcacagct	7	6	2	4			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr14:103933475A>C	uc001ymz.3	+	11	1723	c.1057A>C	c.(1057-1059)AAA>CAA	p.K353Q	MARK3_uc001ymx.3_Missense_Mutation_p.K353Q|MARK3_uc001ymw.3_Missense_Mutation_p.K353Q|MARK3_uc001yna.3_Missense_Mutation_p.K353Q|MARK3_uc001ymy.3_Missense_Mutation_p.K274Q|MARK3_uc010awp.2_Missense_Mutation_p.K376Q|MARK3_uc010tyb.1_Missense_Mutation_p.K164Q	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	353	UBA.						ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			TAGTAAGATGAAATACGATGA	0.328													C	103933475	C	C	103933475	3	2	230	1	0	0	0	0	1	0	0	0	9314	247	9	5	1099	5	MARK3	14	103933475	Missense_Mutation	SNP	A	TCGA-32-2495-01A-01D-1353-08	79031826	103933475	3416065	74	16277											
C15orf2	23742	broad.mit.edu	37	chr15	24924482	24924482	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgtctgtttccaacttccGtaagagcacctgtggttcac	8	12	2	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr15:24924482G>A	uc001ywo.2	+	1	3942	c.3468G>A	c.(3466-3468)CCG>CCA	p.P1156P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	1156					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCCAACTTCCGTAAGAGCACC	0.423													A	24924482	A	A	24924482	2	1	230	1	0	0	0	0	0	0	0	1	1784	1132	40	1		1	C15orf2	15	24924482	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08		24924482	77606910	75	16278											
GRIN2A	2903	broad.mit.edu	37	chr16	10032404	10032404	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggaagaaggtagacgtcGgatcctgccagtgaaaagaa	13	7	0	4	rs142566406		TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr16:10032404G>A	uc002czo.3	-	3	967	c.419C>T	c.(418-420)CCG>CTG	p.P140L	GRIN2A_uc010uym.1_Missense_Mutation_p.P140L|GRIN2A_uc010uyn.1_5'UTR|GRIN2A_uc002czr.3_Missense_Mutation_p.P140L	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	140	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGTAGACGTCGGATCCTGCCA	0.478													A	10032404	A	A	10032404	3	1	230	1	0	0	0	0	1	0	0	0	6779	1116	39	2	4019	2	GRIN2A	16	10032404	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08		10032404	80322349	76	16279											
MYH11	4629	broad.mit.edu	37	chr16	15811149	15811149	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tcgagctgctgccgggcactCtcattcttctgggccgtgct	12	14	3	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr16:15811149C>G	uc002ddy.2	-	38	5459	c.5352G>C	c.(5350-5352)GAG>GAC	p.E1784D	MYH11_uc002ddv.2_Missense_Mutation_p.E1791D|MYH11_uc002ddw.2_Missense_Mutation_p.E1784D|MYH11_uc002ddx.2_Missense_Mutation_p.E1791D|MYH11_uc010bvg.2_Missense_Mutation_p.E1616D|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.E490D	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1784	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GCCGGGCACTCTCATTCTTCT	0.647			T	CBFB	AML								G	15811149	G	G	15811149	3	3	230	1	0	0	0	0	1	0	0	0	10031	912	32	5	617	5	MYH11	16	15811149	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	5778745	15811149	74543604	77	16280											
DNAH3	55567	broad.mit.edu	37	chr16	20952865	20952865	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgccaactcctcaaccacttCcttaaaatgcaggcagaaga	6	13	1	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr16:20952865C>T	uc010vbe.1	-	59	11512	c.11512G>A	c.(11512-11514)GAA>AAA	p.E3838K	DNAH3_uc010vbd.1_Missense_Mutation_p.E1273K	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3838					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCAACCACTTCCTTAAAATGC	0.453													T	20952865	T	T	20952865	3	4	230	1	0	0	0	0	1	0	0	0	4603	869	30	3	853	3	DNAH3	16	20952865	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	5141716	20952865	69401888	78	16281											
OTOA	146183	broad.mit.edu	37	chr16	21698929	21698929	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagccagacatcacagagCggctccctcgggacctgcgc	11	17	1	2	rs148114778		TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr16:21698929C>T	uc002djh.2	+	7	596	c.595C>T	c.(595-597)CGG>TGG	p.R199W	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.R120W	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	199					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		CATCACAGAGCGGCTCCCTCG	0.473													T	21698929	T	T	21698929	3	4	230	1	0	0	0	0	1	0	0	0	11302	759	27	1	655	1	OTOA	16	21698929	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	746064	21698929	68655824	79	16282											
SETD1A	9739	broad.mit.edu	37	chr16	30975479	30975479	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaggcaccactgcggtggGcactcctggcaacggcaccc	13	16	0	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr16:30975479G>A	uc002ead.1	+	6	1390	c.704G>A	c.(703-705)GGC>GAC	p.G235D	SETD1A_uc002eae.1_Missense_Mutation_p.G235D	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						ACTGCGGTGGGCACTCCTGGC	0.627													A	30975479	A	A	30975479	3	1	230	1	0	0	0	0	1	0	0	0	14130	1203	42	3	722	3	SETD1A	16	30975479	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	9276550	30975479	59379274	80	16283											
ARHGEF15	22899	broad.mit.edu	37	chr17	8219094	8219094	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttctagcaacgctcctgtcCcgtgtgcgctcttcccccca	7	18	2	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr17:8219094C>T	uc002glc.2	+	8	1564	c.1443C>T	c.(1441-1443)TCC>TCT	p.S481S	ARHGEF15_uc002gld.2_Silent_p.S481S|ARHGEF15_uc010vuw.1_Silent_p.S370S	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	481	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CGCTCCTGTCCCGTGTGCGCT	0.582													T	8219094	T	T	8219094	2	4	230	1	0	0	0	0	0	0	0	1	898	610	22	3		3	ARHGEF15	17	8219094	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08		8219094	72976116	81	16284											
RNF112	7732	broad.mit.edu	37	chr17	19316608	19316608	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcaggagtctggtgagggcGgccggccaagaggaggagag	21	7	1	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr17:19316608G>A	uc010vyw.1	+	5	803	c.604G>A	c.(604-606)GGC>AGC	p.G202S	RNF112_uc010vyu.1_3'UTR|RNF112_uc010vyv.1_Missense_Mutation_p.G202S|RNF112_uc010vyx.1_Missense_Mutation_p.G85S	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	202							GTP binding|GTPase activity|zinc ion binding			ovary(2)	2						TGGTGAGGGCGGCCGGCCAAG	0.652													A	19316608	A	A	19316608	3	1	230	1	0	0	0	0	1	0	0	0	13426	1116	39	2	332	2	RNF112	17	19316608	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	11097514	19316608	61878602	82	16285											
KRT37	8688	broad.mit.edu	37	chr17	39580498	39580498	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtgtttttgccgtaggccCcacagattccgatgttgccg	13	11	0	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr17:39580498C>T	uc002hwp.1	-	1	325	c.278G>A	c.(277-279)GGG>GAG	p.G93E	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	93	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GCCGTAGGCCCCACAGATTCC	0.602													T	39580498	T	T	39580498	3	4	230	1	0	0	0	0	1	0	0	0	8474	623	22	3	1099	3	KRT37	17	39580498	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	20263890	39580498	41614712	83	16286											
TRIM65	201292	broad.mit.edu	37	chr17	73887344	73887344	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcctgggccccgggactgaCgacagtgcttcacctgctgg	14	15	1	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr17:73887344C>T	uc002jpx.2	-	6	1106	c.1070G>A	c.(1069-1071)CGT>CAT	p.R357H		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	357	B30.2/SPRY.					intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCGGGACTGACGACAGTGCTT	0.627													T	73887344	T	T	73887344	3	4	230	1	0	0	0	0	1	0	0	0	16536	536	19	1	487	1	TRIM65	17	73887344	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	34306846	73887344	7307866	84	16287											
SMCHD1	23347	broad.mit.edu	37	chr18	2770043	2770044	+	Frame_Shift_Del	DEL	CA	-	-													aagaaaaggaccaattatctCagtctattgttatgtataaa							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr18:2770043_2770044delCA	uc002klm.3	+	39	5092_5093	c.4903_4904delCA	c.(4903-4905)CAGfs	p.Q1635fs	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1635					chromosome organization		ATP binding				0						CCAATTATCTCAGTCTATTGTT	0.277													-	2770044	-	-	2770043	7	5	230	1	0	1	0	1	0	0	0	0	14788	827	29	0	5057	0	SMCHD1	18	2770043	Frame_Shift_Del	DEL	CA	TCGA-32-2495-01A-01D-1353-08		2770043	75307205	85	16288											
ZNF519	162655	broad.mit.edu	37	chr18	14105942	14105942	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttgaatatggatattttcAgggaaaataagctttgagga	10	2	1	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr18:14105942A>G	uc002kst.1	-	3	750	c.597T>C	c.(595-597)CCT>CCC	p.P199P	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	199	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGATATTTTCAGGGAAAATAA	0.284													G	14105942	G	G	14105942	2	3	230	1	0	0	0	0	0	0	0	1	17961	175	7	4		4	ZNF519	18	14105942	Silent	SNP	A	TCGA-32-2495-01A-01D-1353-08	11335899	14105942	63971306	86	16289											
ELP2	55250	broad.mit.edu	37	chr18	33740957	33740957	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ttcaaagactctgcttgcctCagcttgtaaggtagggaagt	11	8	3	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr18:33740957C>G	uc002kzk.1	+	17	1761	c.1751C>G	c.(1750-1752)TCA>TGA	p.S584*	ELP2_uc010xcg.1_Nonsense_Mutation_p.S649*|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Nonsense_Mutation_p.S558*|ELP2_uc010xch.1_Nonsense_Mutation_p.S579*|ELP2_uc002kzn.1_Nonsense_Mutation_p.S514*|ELP2_uc002kzo.1_Nonsense_Mutation_p.S514*	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	584	WD 10.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						CTGCTTGCCTCAGCTTGTAAG	0.363													G	33740957	G	G	33740957	4	3	230	1	0	0	0	0	0	1	0	0	5080	838	29	5	1817	5	ELP2	18	33740957	Nonsense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	19635015	33740957	44336291	87	16290											
RTTN	25914	broad.mit.edu	37	chr18	67684705	67684705	+	Frame_Shift_Del	DEL	G	-	-													cattatgaaagataagaagaGgcaataaagggctgctcttg							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr18:67684705delG	uc002lkp.2	-	46	6427	c.6359delC	c.(6358-6360)CCTfs	p.P2120fs	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Frame_Shift_Del_p.P1208fs|RTTN_uc002lkn.2_Frame_Shift_Del_p.P110fs|RTTN_uc010dqp.2_Frame_Shift_Del_p.P372fs	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	2120							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				GATAAGAAGAGGCAATAAAGG	0.388													-	67684705	-	-	67684705	7	5	230	1	0	1	0	1	0	0	0	0	13737	1000	35	0	337	0	RTTN	18	67684705	Frame_Shift_Del	DEL	G	TCGA-32-2495-01A-01D-1353-08	33943748	67684705	10392543	88	16291											
RTTN	25914	broad.mit.edu	37	chr18	67871471	67871471	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaactctactgcaccaacgTcaaccaaatgttggactgct	7	12	2	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr18:67871471T>C	uc002lkp.2	-	3	316	c.248A>G	c.(247-249)GAC>GGC	p.D83G	RTTN_uc010xfb.1_5'UTR|RTTN_uc002lkq.1_Missense_Mutation_p.D83G	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	83							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TGCACCAACGTCAACCAAATG	0.388													C	67871471	C	C	67871471	3	2	230	1	0	0	0	0	1	0	0	0	13737	1667	58	4	6620	4	RTTN	18	67871471	Missense_Mutation	SNP	T	TCGA-32-2495-01A-01D-1353-08	186766	67871471	10205777	89	16292											
NFATC1	4772	broad.mit.edu	37	chr18	77246687	77246687	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcgaacactcgctctgcccCagcagcccctctcctccact	5	22	2	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr18:77246687C>T	uc010xfg.1	+	9	2985	c.2532C>T	c.(2530-2532)CCC>CCT	p.P844P	NFATC1_uc002lnd.2_Intron|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Silent_p.P372P|NFATC1_uc002lnf.2_Silent_p.P831P|NFATC1_uc002lng.2_Intron|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	844	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CGCTCTGCCCCAGCAGCCCCT	0.751													T	77246687	T	T	77246687	2	4	230	1	0	0	0	0	0	0	0	1	10361	581	21	3		3	NFATC1	18	77246687	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	9375216	77246687	830561	90	16293											
PQLC1	80148	broad.mit.edu	37	chr18	77679330	77679330	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgatgtagcccgccacgccCgtgaaggccaggacgcactg	14	14	0	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr18:77679330C>T	uc002lnl.2	-	5	634	c.462G>A	c.(460-462)ACG>ACA	p.T154T	PQLC1_uc010dre.2_Silent_p.T71T|PQLC1_uc002lnk.2_Silent_p.T136T|PQLC1_uc010xfm.1_Intron	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	154	Helical; (Potential).					integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		CCGCCACGCCCGTGAAGGCCA	0.627													T	77679330	T	T	77679330	2	4	230	1	0	0	0	0	0	0	0	1	12418	639	23	2		2	PQLC1	18	77679330	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	432643	77679330	397918	91	16294											
FBN3	84467	broad.mit.edu	37	chr19	8176044	8176044	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgttgtcacagaggtccaCgttctcggcacattcatccc	8	16	3	1	rs117092804	by1000genomes	TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:8176044C>T	uc002mjf.2	-	32	4129	c.4108G>A	c.(4108-4110)GTG>ATG	p.V1370M		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1370	EGF-like 21; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CAGAGGTCCACGTTCTCGGCA	0.657													T	8176044	T	T	8176044	3	4	230	1	0	0	0	0	1	0	0	0	5704	536	19	1	4449	1	FBN3	19	8176044	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08		8176044	50952939	92	16295											
FBN3	84467	broad.mit.edu	37	chr19	8201272	8201272	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccacctggccgcggctcacCaatgcactcgccgcgcacgt	10	19	1	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:8201272C>T	uc002mjf.2	-	10	1366	c.1345G>A	c.(1345-1347)GAT>AAT	p.D449N		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	449	EGF-like 4; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CGCGGCTCACCAATGCACTCG	0.652													T	8201272	T	T	8201272	3	4	230	1	0	0	0	0	1	0	0	0	5704	608	21	3	7300	3	FBN3	19	8201272	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	25228	8201272	50927711	93	16296											
RDH8	50700	broad.mit.edu	37	chr19	10131987	10131987	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgaggggaagcttctggCgcaggtttctatggctgagt	16	6	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:10131987C>T	uc002mmr.2	+	5	842	c.593C>T	c.(592-594)GCG>GTG	p.A198V		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	198					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	AAGCTTCTGGCGCAGGTTTCT	0.602													T	10131987	T	T	10131987	3	4	230	1	0	0	0	0	1	0	0	0	13196	768	27	1	611	1	RDH8	19	10131987	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	1930715	10131987	48996996	94	16297											
OR10H5	284433	broad.mit.edu	37	chr19	15905052	15905052	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtacctcttcctgtgtgCcctctccatcaccgagatcc	6	17	3	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:15905052C>T	uc010xos.1	+	1	194	c.194C>T	c.(193-195)GCC>GTC	p.A65V		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTCCTGTGTGCCCTCTCCATC	0.627													T	15905052	T	T	15905052	3	4	230	1	0	0	0	0	1	0	0	0	10909	739	26	3	196	3	OR10H5	19	15905052	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	5773065	15905052	43223931	95	16298											
TMEM59L	25789	broad.mit.edu	37	chr19	18724803	18724803	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaagctccaagcccaatgCcacccaaactgagtgtgaag	9	13	0	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:18724803C>T	uc002njy.3	+	2	380	c.293C>T	c.(292-294)GCC>GTC	p.A98V	TMEM59L_uc010ebu.1_Missense_Mutation_p.A98V	NM_012109	NP_036241	Q9UK28	TM59L_HUMAN	brain-specific membrane-anchored protein	98						Golgi membrane|integral to membrane|membrane fraction				ovary(2)|skin(2)	4						AAGCCCAATGCCACCCAAACT	0.652													T	18724803	T	T	18724803	3	4	230	1	0	0	0	0	1	0	0	0	16183	739	26	3	299	3	TMEM59L	19	18724803	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	2819751	18724803	40404180	96	16299											
TSHZ3	57616	broad.mit.edu	37	chr19	31767776	31767776	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaatcgttacaaaagaagaCggggtggccagtgtccaagt	12	8	0	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:31767776C>T	uc002nsy.3	-	2	2988	c.2923G>A	c.(2923-2925)GTC>ATC	p.V975I		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	975					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CAAAAGAAGACGGGGTGGCCA	0.512													T	31767776	T	T	31767776	3	4	230	1	0	0	0	0	1	0	0	0	16622	536	19	1	326	1	TSHZ3	19	31767776	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	13042973	31767776	27361207	97	16300											
RYR1	6261	broad.mit.edu	37	chr19	38990563	38990563	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagctttggtgaggaaccGcctgaagaaaaccgggtgca	14	9	0	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:38990563G>A	uc002oit.2	+	45	7360	c.7230G>A	c.(7228-7230)CCG>CCA	p.P2410P	RYR1_uc002oiu.2_Silent_p.P2410P|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2410	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTGAGGAACCGCCTGAAGAAA	0.632													A	38990563	A	A	38990563	2	1	230	1	0	0	0	0	0	0	0	1	13768	1074	38	1		1	RYR1	19	38990563	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08	7222787	38990563	20138420	98	16301											
PVRL2	5819	broad.mit.edu	37	chr19	45389216	45389216	+	Frame_Shift_Del	DEL	A	-	-													tggagggacctccctcctacAagccaccaaccccaaaagcg							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:45389216delA	uc002ozw.1	+	7	1609	c.1219delA	c.(1219-1221)AAGfs	p.K407fs		NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	407	Cytoplasmic (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		TCCCTCCTACAAGCCACCAAC	0.483													-	45389216	-	-	45389216	7	5	230	1	0	1	0	1	0	0	0	0	12840	131	5	0	1647	0	PVRL2	19	45389216	Frame_Shift_Del	DEL	A	TCGA-32-2495-01A-01D-1353-08	6398653	45389216	13739767	99	16302											
FUT1	2523	broad.mit.edu	37	chr19	49253750	49253750	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctttacaccactccatgccGttgctggtgaccacgaaaac	7	14	1	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:49253750G>A	uc002pkk.2	-	4	1764	c.789C>T	c.(787-789)AAC>AAT	p.N263N		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	263	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		ACTCCATGCCGTTGCTGGTGA	0.617													A	49253750	A	A	49253750	2	1	230	1	0	0	0	0	0	0	0	1	6101	1136	40	1		1	FUT1	19	49253750	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08	3864534	49253750	9875233	100	16303											
ZNF528	84436	broad.mit.edu	37	chr19	52918768	52918768	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tgcagtgaatgtggcaaggtCtttagttgcagttcaaagct	12	6	2	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:52918768C>G	uc002pzh.2	+	7	1089	c.663C>G	c.(661-663)GTC>GTG	p.V221V	ZNF528_uc002pzi.2_5'UTR	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	221	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GTGGCAAGGTCTTTAGTTGCA	0.413													G	52918768	G	G	52918768	2	3	230	1	0	0	0	0	0	0	0	1	17966	900	32	5		5	ZNF528	19	52918768	Silent	SNP	C	TCGA-32-2495-01A-01D-1353-08	3665018	52918768	6210215	101	16304											
KIR2DS4	3809	broad.mit.edu	37	chr19	55349278	55349278	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgctacggttctgttcctcaCtccccctatcagttgtcagc	7	15	4	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:55349278C>A	uc002qhm.1	+	3	364	c.318C>A	c.(316-318)CAC>CAA	p.H106Q	KIR2DS4_uc010yfj.1_Missense_Mutation_p.H99Q|KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Missense_Mutation_p.H106Q|KIR2DS4_uc002qhn.1_Missense_Mutation_p.H53Q	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	106	Extracellular (Potential).|Ig-like C2-type 1.					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		CTGTTCCTCACTCCCCCTATC	0.512													A	55349278	A	A	55349278	3	1	230	1	0	0	0	0	1	0	0	0	8319	564	20	5	328	5	KIR2DS4	19	55349278	Missense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	2430510	55349278	3779705	102	16305											
ZNF274	10782	broad.mit.edu	37	chr19	58723892	58723892	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaaaattcctcctagaaaaCgattgcgcaaacgtgactca	6	11	1	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr19:58723892C>T	uc002qrq.1	+	10	1804	c.1345C>T	c.(1345-1347)CGA>TGA	p.R449*	ZNF274_uc002qrr.1_Nonsense_Mutation_p.R417*|ZNF274_uc002qrs.1_Nonsense_Mutation_p.R344*|ZNF274_uc010eum.1_Nonsense_Mutation_p.R208*	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	449					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		TCCTAGAAAACGATTGCGCAA	0.428													T	58723892	T	T	58723892	4	4	230	1	0	0	0	0	0	1	0	0	17806	528	19	1	1370	1	ZNF274	19	58723892	Nonsense_Mutation	SNP	C	TCGA-32-2495-01A-01D-1353-08	3374614	58723892	405091	103	16306											
WFDC11	259239	broad.mit.edu	37	chr20	44278019	44278020	+	Missense_Mutation	DNP	TT	AA	AA													tttggctttccccagcattcTtcaagtaacaattccttccc							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr20:44278019_44278020TT>AA	uc002xpa.2	-	4	314_315	c.119_120AA>TT	c.(118-120)GAA>GTT	p.E40V		NM_147197	NP_671730	Q8NEX6	WFD11_HUMAN	WAP four-disulfide core domain 11 precursor	40						extracellular region					0		Myeloproliferative disorder(115;0.0122)				CCCAGCATTCTTCAAGTAACAA	0.391													AA	44278020	AA	AA	44278019	3	1	230	1	0	0	0	0	1	0	0	0	17346	1606	56	5	151	5	WFDC11	20	44278019	Missense_Mutation	DNP	TT	TCGA-32-2495-01A-01D-1353-08		44278019	18747501	104	16307											
KRTAP6-2	337967	broad.mit.edu	37	chr21	31971188	31971188	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtttccgtagtagctgccGcacatcgtgatggttgtgga	13	8	0	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr21:31971188G>A	uc011adc.1	-	1	6	c.6C>T	c.(4-6)TGC>TGT	p.C2C	KRTAP22-1_uc011add.1_5'Flank	NM_181604	NP_853635	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	2						intermediate filament					0						AGTAGCTGCCGCACATCGTGA	0.483													A	31971188	A	A	31971188	2	1	230	1	0	0	0	0	0	0	0	1	8570	1079	38	1		1	KRTAP6-2	21	31971188	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08		31971188	16158707	105	16308											
DSCR6	53820	broad.mit.edu	37	chr21	38380461	38380461	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcttgccgttccagccccGcgccgtggcgaccttggatc	13	17	0	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr21:38380461G>A	uc002yvv.2	+	2	319	c.109G>A	c.(109-111)GCG>ACG	p.A37T	DSCR6_uc011aec.1_5'UTR|DSCR6_uc010gnd.2_5'UTR	NM_018962	NP_061835	P57055	DSCR6_HUMAN	Down syndrome critical region protein 6	37						nucleus				breast(1)	1		Myeloproliferative disorder(46;0.0632)				TTCCAGCCCCGCGCCGTGGCG	0.582													A	38380461	A	A	38380461	3	1	230	1	0	0	0	0	1	0	0	0	4773	1087	38	1	115	1	DSCR6	21	38380461	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	6409273	38380461	9749434	106	16309											
MCM3AP	8888	broad.mit.edu	37	chr21	47662773	47662773	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acctggcttgttcccacgacAaaggaacatcatattttttc	6	11	1	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr21:47662773A>C	uc002zir.1	-	25	5405	c.5369T>G	c.(5368-5370)TTG>TGG	p.L1790W	MCM3APAS_uc002zim.2_Intron|MCM3APAS_uc002zin.2_Intron|MCM3AP_uc002zio.1_Missense_Mutation_p.L285W|MCM3AP_uc002zip.1_Missense_Mutation_p.L531W|MCM3AP_uc002ziq.1_Missense_Mutation_p.L717W|MCM3APAS_uc002zis.1_Intron	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1790					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					TTCCCACGACAAAGGAACATC	0.403													C	47662773	C	C	47662773	3	2	230	1	0	0	0	0	1	0	0	0	9388	131	5	5	589	5	MCM3AP	21	47662773	Missense_Mutation	SNP	A	TCGA-32-2495-01A-01D-1353-08	9282312	47662773	467122	107	16310											
HSCB	150274	broad.mit.edu	37	chr22	29147228	29147228	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaatggttttctttttcaGctaaacagaaagaatttact	6	6	2	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chr22:29147228G>A	uc003aea.2	+	5	610	c.569_splice	c.e5-1	p.A190_splice		NM_172002	NP_741999	Q8IWL3	HSC20_HUMAN	J-type co-chaperone HSC20 precursor						iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)	1						TTCTTTTTCAGCTAAACAGAA	0.299													A	29147228	A	A	29147228	5	1	230	1	0	0	0	0	0	0	1	0	7374	985	34	3	586	3	HSCB	22	29147228	Splice_Site	SNP	G	TCGA-32-2495-01A-01D-1353-08		29147228	22157338	108	16311											
ARSH	347527	broad.mit.edu	37	chrX	2933417	2933417	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccctcatgctgaaggaggcActtgctttcattgaaaggta	10	9	2	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:2933417A>G	uc011mhj.1	+	4	747	c.747A>G	c.(745-747)GCA>GCG	p.A249A		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	249						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TGAAGGAGGCACTTGCTTTCA	0.398													G	2933417	G	G	2933417	2	3	230	1	0	0	0	0	0	0	0	1	993	146	6	4		4	ARSH	23	2933417	Silent	SNP	A	TCGA-32-2495-01A-01D-1353-08		2933417	152337143	109	16312											
FRMPD4	9758	broad.mit.edu	37	chrX	12736450	12736450	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acttagataacccagaggacGctgactcgtccacctgcgac	9	14	0	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:12736450G>A	uc004cuz.1	+	16	4011	c.3505G>A	c.(3505-3507)GCT>ACT	p.A1169T	FRMPD4_uc011mij.1_Missense_Mutation_p.A1161T	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1169					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CCCAGAGGACGCTGACTCGTC	0.542													A	12736450	A	A	12736450	3	1	230	1	0	0	0	0	1	0	0	0	6059	1087	38	1	3567	1	FRMPD4	23	12736450	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	9803033	12736450	142534110	110	16313											
CXorf59	286464	broad.mit.edu	37	chrX	36091481	36091481	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tattccagagactataagaaGgtgagagtcccatgtttctc	9	8	1	3			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:36091481G>T	uc004ddk.1	+	4	602	c.416G>T	c.(415-417)AGG>ATG	p.R139M		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	139						integral to membrane				central_nervous_system(1)	1						ACTATAAGAAGGTGAGAGTCC	0.343													T	36091481	T	T	36091481	3	4	230	1	0	0	0	0	1	0	0	0	4115	1014	35	5	426	5	CXorf59	23	36091481	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	23355031	36091481	119179079	111	16314											
BCOR	54880	broad.mit.edu	37	chrX	39911637	39911637	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttaaggacatccgaaagcaGtagccagtttcgtggcctac	10	11	0	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:39911637G>T	uc004den.3	-	15	5285	c.4993C>A	c.(4993-4995)CTG>ATG	p.L1665M	BCOR_uc004dep.3_Missense_Mutation_p.L1631M|BCOR_uc004deo.3_Missense_Mutation_p.L1613M|BCOR_uc010nhb.2_3'UTR|BCOR_uc004dem.3_Missense_Mutation_p.L1631M	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1665					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TCCGAAAGCAGTAGCCAGTTT	0.393													T	39911637	T	T	39911637	3	4	230	1	0	0	0	0	1	0	0	0	1386	1020	36	5	278	5	BCOR	23	39911637	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	3820156	39911637	115358923	112	16315											
HUWE1	10075	broad.mit.edu	37	chrX	53571567	53571567	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgttagcccggcgcgtgtcGtcccggagctggatgatgac	15	11	0	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:53571567G>A	uc004dsp.2	-	72	11607	c.11205C>T	c.(11203-11205)GAC>GAT	p.D3735D	HUWE1_uc004dsn.2_Silent_p.D2543D|HUWE1_uc004dsq.1_Silent_p.D50D	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3735					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GGCGCGTGTCGTCCCGGAGCT	0.552													A	53571567	A	A	53571567	2	1	230	1	0	0	0	0	0	0	0	1	7461	1136	40	1		1	HUWE1	23	53571567	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08	13659930	53571567	101698993	113	16316											
OPHN1	4983	broad.mit.edu	37	chrX	67331781	67331781	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagtgaatagctcctaggcGgtaatccaggttgtcagact	13	8	1	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:67331781G>A	uc004dww.3	-	18	1735	c.1441C>T	c.(1441-1443)CGC>TGC	p.R481C	OPHN1_uc011mpg.1_Missense_Mutation_p.R481C	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	481	Rho-GAP.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						GCTCCTAGGCGGTAATCCAGG	0.403													A	67331781	A	A	67331781	3	1	230	1	0	0	0	0	1	0	0	0	10875	1116	39	2	995	2	OPHN1	23	67331781	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	13760214	67331781	87938779	114	16317											
TAF1	6872	broad.mit.edu	37	chrX	70598242	70598246	+	Frame_Shift_Del	DEL	ACTAT	-	-													tgaagatggcagtgggtttgActatggcttcaaactgagaa							TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:70598242_70598246delACTAT	uc004dzu.3	+	7	1139_1143	c.1088_1092delACTAT	c.(1087-1092)GACTATfs	p.D363fs	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Frame_Shift_Del_p.D384fs	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	363_364	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AGTGGGTTTGACTATGGCTTCAAAC	0.454													-	70598246	-	-	70598242	7	5	230	1	0	1	0	1	0	0	0	0	15510	275	10	0	1177	0	TAF1	23	70598242	Frame_Shift_Del	DEL	ACTAT	TCGA-32-2495-01A-01D-1353-08	3266461	70598242	84672318	115	16318											
CAPN6	827	broad.mit.edu	37	chrX	110494471	110494471	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atcagacataacaagccccaGgttcttgcgatctgatgcag	9	11	3	2			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:110494471G>C	uc004epc.1	-	7	1105	c.937C>G	c.(937-939)CTG>GTG	p.L313V	CAPN6_uc011msu.1_Missense_Mutation_p.L58V	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	313	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						ACAAGCCCCAGGTTCTTGCGA	0.393													C	110494471	C	C	110494471	3	2	230	1	0	0	0	0	1	0	0	0	2630	991	35	5	1016	5	CAPN6	23	110494471	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	39896229	110494471	44776089	116	16319											
GRIA3	2892	broad.mit.edu	37	chrX	122538688	122538688	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaaatacaaattgtccatcGttggtgacgggaaatatggt	10	6	1	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:122538688G>A	uc004etq.3	+	11	1716	c.1423G>A	c.(1423-1425)GTT>ATT	p.V475I	GRIA3_uc004etr.3_Missense_Mutation_p.V475I|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.V459I	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	475	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	ATTGTCCATCGTTGGTGACGG	0.418													A	122538688	A	A	122538688	3	1	230	1	0	0	0	0	1	0	0	0	6769	1145	40	1	1461	1	GRIA3	23	122538688	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	12044217	122538688	32731872	117	16320											
GPR112	139378	broad.mit.edu	37	chrX	135496349	135496349	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ccggtgtcagataaaggttgGatataaacaggagggactaa	13	5	1	1			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:135496349G>C	uc004ezu.1	+	25	9359	c.9068G>C	c.(9067-9069)GGA>GCA	p.G3023A	GPR112_uc010nsb.1_Missense_Mutation_p.G2818A	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	3023	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ATAAAGGTTGGATATAAACAG	0.318													C	135496349	C	C	135496349	3	2	230	1	0	0	0	0	1	0	0	0	6629	1174	41	5	9154	5	GPR112	23	135496349	Missense_Mutation	SNP	G	TCGA-32-2495-01A-01D-1353-08	12957661	135496349	19774211	118	16321											
PLXNA3	55558	broad.mit.edu	37	chrX	153694760	153694760	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtcccagccgtggcccggcGtccgggggcacacggcttac	15	16	0	0			TCGA-32-2495-01A-01D-1353-08	TCGA-32-2495-10B-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f41d5328-3310-4384-be5a-775bdbb2393f	0fe3a646-734e-4f89-b0cf-1c3b4c5b2285	g.chrX:153694760G>A	uc004flm.2	+	16	3014	c.2841G>A	c.(2839-2841)GCG>GCA	p.A947A		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	947	IPT/TIG 2.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTGGCCCGGCGTCCGGGGGCA	0.662													A	153694760	A	A	153694760	2	1	230	1	0	0	0	0	0	0	0	1	12121	1132	40	1		1	PLXNA3	23	153694760	Silent	SNP	G	TCGA-32-2495-01A-01D-1353-08	18198411	153694760	1575800	119	16322											
FAF1	11124	broad.mit.edu	37	chr1	51001131	51001131	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatctactgttgtgttcccTaaaaacatatagagattgcc	6	9	2	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr1:51001131T>C	uc009vyx.1	-	16	1469	c.1406_splice	c.e16-1	p.G469_splice	FAF1_uc009vyw.1_Splice_Site|FAF1_uc001cse.1_Splice_Site_p.G469_splice|FAF1_uc010onc.1_Splice_Site_p.G227_splice	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1						apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		TTGTGTTCCCTAAAAACATAT	0.323													C	51001131	C	C	51001131	5	2	231	1	0	0	0	0	0	0	1	0	5369	1536	53	4	568	4	FAF1	1	51001131	Splice_Site	SNP	T	TCGA-32-2615-01A-01D-1495-08		51001131	198249490	1	16323											
C1orf161	126868	broad.mit.edu	37	chr1	116666896	116666896	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catgagacagatgtgaacatCgacggagacattgtgcctgc	12	9	0	4			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr1:116666896C>T	uc001egc.1	+	4	664	c.399C>T	c.(397-399)ATC>ATT	p.I133I		NM_152367	NP_689580	Q8N8X9	MB213_HUMAN	hypothetical protein LOC126868	133											0	Lung SC(450;0.184)	all_cancers(81;0.00142)|all_lung(203;0.000139)|all_epithelial(167;0.000401)|Lung NSC(69;0.000705)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		ATGTGAACATCGACGGAGACA	0.557													T	116666896	T	T	116666896	2	4	231	1	0	0	0	0	0	0	0	1	2009	874	31	2		2	C1orf161	1	116666896	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08	65665765	116666896	132583725	2	16324											
ASTN1	460	broad.mit.edu	37	chr1	176993825	176993825	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	acacagctggtgatgctgatCagggtcaaggtggtcttatt	13	7	3	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr1:176993825C>A	uc001glc.2	-	6	1376	c.1164G>T	c.(1162-1164)CTG>CTT	p.L388L	ASTN1_uc001glb.1_Silent_p.L388L|ASTN1_uc001gld.1_Silent_p.L388L|ASTN1_uc009wwx.1_Silent_p.L388L|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	388	Helical; (Potential).				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TGATGCTGATCAGGGTCAAGG	0.512													A	176993825	A	A	176993825	2	1	231	1	0	0	0	0	0	0	0	1	1064	813	29	5		5	ASTN1	1	176993825	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08	60326929	176993825	72256796	3	16325											
PROX1	5629	broad.mit.edu	37	chr1	214209144	214209144	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtccctgagattttcaaatcCccgaactgcctacaagagct	7	13	1	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr1:214209144C>G	uc001hkh.2	+	5	2453	c.2181C>G	c.(2179-2181)TCC>TCG	p.S727S		NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	727	Prospero-like.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TTTTCAAATCCCCGAACTGCC	0.423													G	214209144	G	G	214209144	2	3	231	1	0	0	0	0	0	0	0	1	12560	610	22	5		5	PROX1	1	214209144	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08	37215319	214209144	35041477	4	16326											
TPO	7173	broad.mit.edu	37	chr2	1480946	1480946	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcaccggggaccaaggcgCgctctttgggaacctgtcca	14	14	1	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr2:1480946C>T	uc002qww.2	+	8	999	c.908C>T	c.(907-909)GCG>GTG	p.A303V	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.A303V|TPO_uc002qwr.2_Missense_Mutation_p.A303V|TPO_uc002qwx.2_Missense_Mutation_p.A303V|TPO_uc010yio.1_Intron|TPO_uc010yip.1_Missense_Mutation_p.A303V	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	303	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GACCAAGGCGCGCTCTTTGGG	0.706													T	1480946	T	T	1480946	3	4	231	1	0	0	0	0	1	0	0	0	16407	768	27	1	934	1	TPO	2	1480946	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08		1480946	241718427	5	16327											
APOB	338	broad.mit.edu	37	chr2	21233706	21233706	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agttaggtcagccagagttcGtccagtaagctccacgccaa	10	12	1	1	rs147863759		TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr2:21233706G>A	uc002red.2	-	26	6162	c.6034C>T	c.(6034-6036)CGA>TGA	p.R2012*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2012					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCCAGAGTTCGTCCAGTAAGC	0.428													A	21233706	A	A	21233706	4	1	231	1	0	0	0	0	0	1	0	0	785	1153	40	1	7673	1	APOB	2	21233706	Nonsense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08	19752760	21233706	221965667	6	16328											
THSD7B	80731	broad.mit.edu	37	chr2	137988734	137988734	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggagtggtcatcctgttcccAgtcctgttcaaataaaaact	8	10	2	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr2:137988734A>C	uc002tva.1	+	7	1751	c.1751A>C	c.(1750-1752)CAG>CCG	p.Q584P	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.Q474P	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TCCTGTTCCCAGTCCTGTTCA	0.507													C	137988734	C	C	137988734	3	2	231	1	0	0	0	0	1	0	0	0	15877	188	7	5	1777	5	THSD7B	2	137988734	Missense_Mutation	SNP	A	TCGA-32-2615-01A-01D-1495-08	116755028	137988734	105210639	7	16329											
ITIH3	3699	broad.mit.edu	37	chr3	52828907	52828907	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgagaagcccctttcggctgCttggggtgagtctgccccct	13	14	1	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr3:52828907C>T	uc003dfv.2	+	1	124	c.88C>T	c.(88-90)CTT>TTT	p.L30F	ITIH3_uc011bek.1_Missense_Mutation_p.L30F	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	30	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CTTTCGGCTGCTTGGGGTGAG	0.572													T	52828907	T	T	52828907	3	4	231	1	0	0	0	0	1	0	0	0	7905	797	28	3	90	3	ITIH3	3	52828907	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08		52828907	145193523	8	16330											
DPPA4	55211	broad.mit.edu	37	chr3	109046840	109046840	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctttttcctgatattctattCccattggaggctttttatta	5	8	1	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr3:109046840C>T	uc003dxq.3	-	7	965	c.910G>A	c.(910-912)GAA>AAA	p.E304K	DPPA4_uc011bho.1_3'UTR	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	304						nucleus	protein binding			upper_aerodigestive_tract(1)	1						ATATTCTATTCCCATTGGAGG	0.373													T	109046840	T	T	109046840	3	4	231	1	0	0	0	0	1	0	0	0	4736	864	30	3	8	3	DPPA4	3	109046840	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08	56217933	109046840	88975590	9	16331											
BOD1L	259282	broad.mit.edu	37	chr4	13605551	13605551	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttgctaatggtaacttggcTctatgactagaatccttctg	8	8	2	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr4:13605551T>C	uc003gmz.1	-	10	3090	c.2973A>G	c.(2971-2973)AGA>AGG	p.R991R	BOD1L_uc010idr.1_Silent_p.R328R	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	991	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						GTAACTTGGCTCTATGACTAG	0.403													C	13605551	C	C	13605551	2	2	231	1	0	0	0	0	0	0	0	1	1483	1548	54	4		4	BOD1L	4	13605551	Silent	SNP	T	TCGA-32-2615-01A-01D-1495-08		13605551	177548725	10	16332											
NUP54	53371	broad.mit.edu	37	chr4	77069476	77069476	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcacccgcgggggccgcggTggctgcagcggtaccggagg	19	14	1	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr4:77069476T>G	uc003hjs.2	-	1	180	c.52A>C	c.(52-54)ACC>CCC	p.T18P	NUP54_uc010ije.2_5'UTR|NUP54_uc011cbs.1_5'UTR|NUP54_uc011cbt.1_Missense_Mutation_p.T18P|NUP54_uc003hjt.2_5'UTR	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	18	Gly-rich.|9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2						GGGGCCGCGGTGGCTGCAGCG	0.667													G	77069476	G	G	77069476	3	3	231	1	0	0	0	0	1	0	0	0	10767	1696	59	5	1519	5	NUP54	4	77069476	Missense_Mutation	SNP	T	TCGA-32-2615-01A-01D-1495-08	63463925	77069476	114084800	11	16333											
PET112L	5188	broad.mit.edu	37	chr4	152680061	152680061	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccaaacctaccacagcagCccatttgtgttcactaagaa	5	13	1	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr4:152680061C>T	uc003iml.2	-	2	202	c.190G>A	c.(190-192)GCT>ACT	p.A64T	PET112L_uc003imm.3_Missense_Mutation_p.A64T	NM_004564	NP_004555	O75879	GATB_HUMAN	PET112-like precursor	64						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding				0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)			L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	ACCACAGCAGCCCATTTGTGT	0.363													T	152680061	T	T	152680061	3	4	231	1	0	0	0	0	1	0	0	0	11734	739	26	3	1531	3	PET112L	4	152680061	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08	75610585	152680061	38474215	12	16334											
EGR1	1958	broad.mit.edu	37	chr5	137803130	137803130	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccaaccggcccagcaagaCgcccccccacgaacgccctt	7	23	0	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr5:137803130C>T	uc003ldb.1	+	2	1262	c.992C>T	c.(991-993)ACG>ATG	p.T331M	EGR1_uc011cyu.1_Intron	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	331					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCCAGCAAGACGCCCCCCCAC	0.652													T	137803130	T	T	137803130	3	4	231	1	0	0	0	0	1	0	0	0	4971	536	19	1	998	1	EGR1	5	137803130	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08		137803130	43112130	13	16335											
PCDHA3	56145	broad.mit.edu	37	chr5	140181750	140181750	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaaatccaggtagaagccaCggataaaggaaatcccccaa	9	10	0	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr5:140181750C>T	uc003lhf.2	+	1	968	c.968C>T	c.(967-969)ACG>ATG	p.T323M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.T323M	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	323	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTAGAAGCCACGGATAAAGGA	0.378													T	140181750	T	T	140181750	3	4	231	1	0	0	0	0	1	0	0	0	11525	536	19	1	970	1	PCDHA3	5	140181750	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08	2378620	140181750	40733510	14	16336											
ARAP3	64411	broad.mit.edu	37	chr5	141041300	141041300	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgcggcggttgacccgcgGcaggcagccaatcacatctt	13	13	2	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr5:141041300G>A	uc003llm.2	-	21	3148	c.3070C>T	c.(3070-3072)CCG>TCG	p.P1024S	ARAP3_uc003lll.2_5'UTR|ARAP3_uc011dbe.1_Missense_Mutation_p.P686S|ARAP3_uc003lln.2_Missense_Mutation_p.P855S	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1024	Rho-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TTGACCCGCGGCAGGCAGCCA	0.572													A	141041300	A	A	141041300	3	1	231	1	0	0	0	0	1	0	0	0	840	1203	42	3	1616	3	ARAP3	5	141041300	Missense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08	859550	141041300	39873960	15	16337											
SH3RF2	153769	broad.mit.edu	37	chr5	145428731	145428731	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcctggggaagtgccaggaCggctggctcaggggcgtctc	18	11	2	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr5:145428731C>T	uc003lnt.2	+	7	1483	c.1245C>T	c.(1243-1245)GAC>GAT	p.D415D	SH3RF2_uc011dbl.1_Silent_p.D415D|SH3RF2_uc011dbm.1_5'Flank|SH3RF2_uc003lnu.2_5'Flank	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	415	SH3 3.						ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTGCCAGGACGGCTGGCTCA	0.597											OREG0016895	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	145428731	T	T	145428731	2	4	231	1	0	0	0	0	0	0	0	1	14259	535	19	1		1	SH3RF2	5	145428731	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08	4387431	145428731	35486529	16	16338											
PRSS16	10279	broad.mit.edu	37	chr6	27216987	27216987	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggaaatggcccagctccGcttcttgtccagccgccttg	10	16	1	0	rs145240806		TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr6:27216987G>A	uc003nja.2	+	4	458	c.446G>A	c.(445-447)CGC>CAC	p.R149H	PRSS16_uc011dkt.1_Intron|PRSS16_uc003njb.2_Intron|PRSS16_uc010jqq.1_Missense_Mutation_p.R39H|PRSS16_uc010jqr.1_Missense_Mutation_p.R39H|PRSS16_uc003njc.1_RNA|PRSS16_uc003njd.2_5'Flank	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	149					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						GCCCAGCTCCGCTTCTTGTCC	0.512													A	27216987	A	A	27216987	3	1	231	1	0	0	0	0	1	0	0	0	12616	1087	38	1	460	1	PRSS16	6	27216987	Missense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08		27216987	143898080	17	16339											
HIST1H2BO	8348	broad.mit.edu	37	chr6	27861564	27861564	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgcccggggagctggcCaagcacgccgtgtccgaggg	17	14	0	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr6:27861564C>T	uc003nkc.1	+	1	362	c.324C>T	c.(322-324)GCC>GCT	p.A108A	HIST1H3J_uc003nka.2_5'Flank|HIST1H2AM_uc003nkb.1_5'Flank	NM_003527	NP_003518	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	108					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GGGAGCTGGCCAAGCACGCCG	0.637													T	27861564	T	T	27861564	2	4	231	1	0	0	0	0	0	0	0	1	7154	581	21	3		3	HIST1H2BO	6	27861564	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08	644577	27861564	143253503	18	16340											
OR2J3	442186	broad.mit.edu	37	chr6	29080293	29080293	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catgatcacaagctccatatTtgttctcatacctctcatcc	3	14	3	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr6:29080293T>C	uc011dll.1	+	1	626	c.626T>C	c.(625-627)TTT>TCT	p.F209S		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCTCCATATTTGTTCTCATA	0.448													C	29080293	C	C	29080293	3	2	231	1	0	0	0	0	1	0	0	0	11004	1841	64	4	628	4	OR2J3	6	29080293	Missense_Mutation	SNP	T	TCGA-32-2615-01A-01D-1495-08	1218729	29080293	142034774	19	16341											
ZBTB12	221527	broad.mit.edu	37	chr6	31868436	31868436	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccggtgtgccacctccaggGccgactccaccttgacgatg	12	16	0	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr6:31868436G>A	uc003nyd.1	-	2	823	c.647C>T	c.(646-648)GCC>GTC	p.A216V	EHMT2_uc003nxz.1_5'Flank|EHMT2_uc003nya.1_5'Flank|EHMT2_uc003nyb.1_5'Flank|C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_5'Flank	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACCTCCAGGGCCGACTCCAC	0.627													A	31868436	A	A	31868436	3	1	231	1	0	0	0	0	1	0	0	0	17522	1203	42	3	736	3	ZBTB12	6	31868436	Missense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08	2788143	31868436	139246631	20	16342											
ZNF318	24149	broad.mit.edu	37	chr6	43325085	43325085	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctcttcctctcgctttcGtctggcaagatccagttctc	6	16	4	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr6:43325085G>A	uc003oux.2	-	3	1045	c.967C>T	c.(967-969)CGA>TGA	p.R323*	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	323	Potential.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TCTCGCTTTCGTCTGGCAAGA	0.522													A	43325085	A	A	43325085	4	1	231	1	0	0	0	0	0	1	0	0	17833	1153	40	1	5904	1	ZNF318	6	43325085	Nonsense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08	11456649	43325085	127789982	21	16343											
IMPG1	3617	broad.mit.edu	37	chr6	76782168	76782169	+	Frame_Shift_Ins	INS	-	A	A													ttgaacttggagaaaaatccINSaaaaaacaaaaatagctctt							TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr6:76782168_76782169insA	uc003pik.1	-	1	167_168	c.37_38insT	c.(37-39)TGGfs	p.W13fs		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	13					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GAGAAAAATCCAAAAAACAAAA	0.287													A	76782169	A	A	76782168	7	5	231	1	0	1	1	0	0	0	0	0	7728	595	21	0	2423	0	IMPG1	6	76782168	Frame_Shift_Ins	INS	-	TCGA-32-2615-01A-01D-1495-08	33457083	76782168	94332899	22	16344											
TNPO3	23534	broad.mit.edu	37	chr7	128612562	128612562	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cccggtggtccagggtagtaGaggcaatggcccactgtaag	15	10	0	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr7:128612562G>A	uc003vol.1	-	19	2722	c.2348C>T	c.(2347-2349)TCT>TTT	p.S783F	TNPO3_uc010llx.1_Missense_Mutation_p.S194F|TNPO3_uc003vom.1_Missense_Mutation_p.S717F|TNPO3_uc010lly.1_Missense_Mutation_p.S817F|TNPO3_uc010llz.1_Missense_Mutation_p.S719F	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	783					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						CAGGGTAGTAGAGGCAATGGC	0.478													A	128612562	A	A	128612562	3	1	231	1	0	0	0	0	1	0	0	0	16334	942	33	3	439	3	TNPO3	7	128612562	Missense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08		128612562	30526101	23	16345											
PARP12	64761	broad.mit.edu	37	chr7	139746776	139746776	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccaagaattgccatcgataCggcaaatggaaatgaactct	8	9	1	2	rs147556524		TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr7:139746776C>T	uc003vvl.1	-	5	1768	c.894G>A	c.(892-894)CCG>CCA	p.P298P	PARP12_uc003vvk.1_Silent_p.P84P|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	298	WWE 1.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					GCCATCGATACGGCAAATGGA	0.403													T	139746776	T	T	139746776	2	4	231	1	0	0	0	0	0	0	0	1	11457	523	19	1		1	PARP12	7	139746776	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08	11134214	139746776	19391887	24	16346											
NOBOX	135935	broad.mit.edu	37	chr7	144097327	144097327	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggggggtcacccccaccGtctgggcaatctctcggcgt	14	15	3	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr7:144097327G>A	uc011kue.1	-	5	923	c.923C>T	c.(922-924)ACG>ATG	p.T308M		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	308	Homeobox.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					CACCCCCACCGTCTGGGCAAT	0.552													A	144097327	A	A	144097327	3	1	231	1	0	0	0	0	1	0	0	0	10512	1145	40	1	1080	1	NOBOX	7	144097327	Missense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08	4350551	144097327	15041336	25	16347											
ZNF282	8427	broad.mit.edu	37	chr7	148920939	148920940	+	Frame_Shift_Ins	INS	-	C	C													ggtgaagaacccacccccggINSccccgccacagccccagccc							TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr7:148920939_148920940insC	uc003wfm.2	+	8	1321_1322	c.1216_1217insC	c.(1216-1218)GCCfs	p.A406fs	ZNF282_uc011kun.1_Frame_Shift_Ins_p.A406fs|ZNF282_uc003wfo.2_Intron	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	406					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		cccacccccggccccgccacag	0.386													C	148920940	C	C	148920939	7	5	231	1	0	1	1	0	0	0	0	0	17816	1203	42	0	1246	0	ZNF282	7	148920939	Frame_Shift_Ins	INS	-	TCGA-32-2615-01A-01D-1495-08	4823612	148920939	10217724	26	16348											
XKR4	114786	broad.mit.edu	37	chr8	56270319	56270319	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggttttactggaaaatggtAtatgagtatgcggatgtgag	14	2	0	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr8:56270319A>G	uc003xsf.2	+	2	920	c.888A>G	c.(886-888)GTA>GTG	p.V296V		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	296						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			GGAAAATGGTATATGAGTATG	0.438													G	56270319	G	G	56270319	2	3	231	1	0	0	0	0	0	0	0	1	17430	436	16	4		4	XKR4	8	56270319	Silent	SNP	A	TCGA-32-2615-01A-01D-1495-08		56270319	90093703	27	16349											
CPSF1	29894	broad.mit.edu	37	chr8	145624369	145624369	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagcaccgacaaagccccGttcttcccgtggccggagca	11	16	1	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr8:145624369G>A	uc003zcj.2	-	16	1602	c.1527C>T	c.(1525-1527)AAC>AAT	p.N509N		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	509					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			ACAAAGCCCCGTTCTTCCCGT	0.627													A	145624369	A	A	145624369	2	1	231	1	0	0	0	0	0	0	0	1	3824	1136	40	1		1	CPSF1	8	145624369	Silent	SNP	G	TCGA-32-2615-01A-01D-1495-08	89354050	145624369	739653	28	16350											
ASS1	445	broad.mit.edu	37	chr9	133342180	133342180	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcaatgacctgatggagtaCgcaaaggtatggccgagtct	13	9	1	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr9:133342180C>T	uc004bzm.2	+	7	845	c.489C>T	c.(487-489)TAC>TAT	p.Y163Y	ASS1_uc004bzn.2_Silent_p.Y163Y|ASS1_uc010mza.2_Silent_p.Y239Y|ASS1_uc004bzo.2_Silent_p.Y144Y|ASS1_uc010mzb.2_Silent_p.Y201Y|ASS1_uc004bzp.2_Silent_p.Y163Y|ASS1_uc010mzc.2_Silent_p.Y163Y	NM_000050	NP_000041	P00966	ASSY_HUMAN	argininosuccinate synthetase 1	163					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	TGATGGAGTACGCAAAGGTAT	0.612													T	133342180	T	T	133342180	2	4	231	1	0	0	0	0	0	0	0	1	1061	547	19	1		1	ASS1	9	133342180	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08		133342180	7871251	29	16351											
AKR1C4	1109	broad.mit.edu	37	chr10	5238864	5238864	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atcagcgtgtagagctaaatGatggtcacttcatgcccgta	10	9	3	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr10:5238864G>A	uc001ihw.2	+	1	67	c.34G>A	c.(34-36)GAT>AAT	p.D12N		NM_001818	NP_001809	P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	12					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			ovary(1)	1					NADH(DB00157)	AGAGCTAAATGATGGTCACTT	0.418													A	5238864	A	A	5238864	3	1	231	1	0	0	0	0	1	0	0	0	472	1290	45	3	36	3	AKR1C4	10	5238864	Missense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08		5238864	130295883	30	16352											
TAF3	83860	broad.mit.edu	37	chr10	8006394	8006394	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaccaaaaactgtatccaaAgaaaagaaatcacctggacg	6	10	2	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr10:8006394A>G	uc010qbd.1	+	3	921	c.921A>G	c.(919-921)AAA>AAG	p.K307K		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	307					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						CTGTATCCAAAGAAAAGAAAT	0.393													G	8006394	G	G	8006394	2	3	231	1	0	0	0	0	0	0	0	1	15522	69	3	4		4	TAF3	10	8006394	Silent	SNP	A	TCGA-32-2615-01A-01D-1495-08	2767530	8006394	127528353	31	16353											
OPN4	94233	broad.mit.edu	37	chr10	88419055	88419055	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctgccctggctcccaggCgcctacgtgcccgaggggtt	13	17	0	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr10:88419055C>T	uc001kdq.2	+	5	857	c.630C>T	c.(628-630)AGC>AGT	p.S210S	OPN4_uc001kdp.2_Silent_p.S221S|OPN4_uc010qmk.1_Silent_p.S221S|OPN4_uc009xsx.1_5'Flank	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	210	Extracellular (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						GGCTCCCAGGCGCCTACGTGC	0.622													T	88419055	T	T	88419055	2	4	231	1	0	0	0	0	0	0	0	1	10882	782	27	1		1	OPN4	10	88419055	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08	80412661	88419055	47115692	32	16354											
LOC729020	729020	broad.mit.edu	37	chr10	105005758	105005758	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgggagccagcggtatggCgtcgggctgcaagattggcc	17	10	0	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr10:105005758C>T	uc009xxi.2	+	1	115	c.5C>T	c.(4-6)GCG>GTG	p.A2V	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	2					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						AGCGGTATGGCGTCGGGCTGC	0.522													T	105005758	T	T	105005758	3	4	231	1	0	0	0	0	1	0	0	0	8888	768	27	1	7	1	LOC729020	10	105005758	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08	16586703	105005758	30528989	33	16355											
OR52M1	119772	broad.mit.edu	37	chr11	4566916	4566916	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacctctgcctctgatgatcCgcctgcggctgcccctttat	9	16	2	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr11:4566916C>T	uc010qyf.1	+	1	496	c.496C>T	c.(496-498)CGC>TGC	p.R166C		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTGATGATCCGCCTGCGGCT	0.522													T	4566916	T	T	4566916	3	4	231	1	0	0	0	0	1	0	0	0	11126	652	23	2	498	2	OR52M1	11	4566916	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08		4566916	130439600	34	16356											
MRVI1	10335	broad.mit.edu	37	chr11	10647541	10647541	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcttggtcagtttctgcatcCgcacgggctgcacttgtatc	11	12	2	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr11:10647541C>G	uc010rcc.1	-	9	1726	c.1340G>C	c.(1339-1341)CGG>CCG	p.R447P	MRVI1_uc001miw.2_Missense_Mutation_p.R438P|MRVI1_uc010rcb.1_Missense_Mutation_p.R439P|MRVI1_uc009ygb.1_Missense_Mutation_p.R132P|MRVI1_uc001mix.2_Missense_Mutation_p.R132P|MRVI1_uc001miz.2_Missense_Mutation_p.R356P|MRVI1_uc009ygc.1_Missense_Mutation_p.R356P|MRVI1_uc010rcd.1_Intron|MRVI1_uc009ygd.1_Missense_Mutation_p.R132P|MRVI1_uc010rce.1_Intron	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	420					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTTCTGCATCCGCACGGGCTG	0.597													G	10647541	G	G	10647541	3	3	231	1	0	0	0	0	1	0	0	0	9853	652	23	5	1450	5	MRVI1	11	10647541	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08	6080625	10647541	124358975	35	16357											
HTR3A	3359	broad.mit.edu	37	chr11	113853896	113853896	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtatattcggcatcaaggCgaagttcagaactacaagcc	10	9	2	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr11:113853896C>T	uc010rxb.1	+	5	680	c.447C>T	c.(445-447)GGC>GGT	p.G149G	HTR3A_uc010rxa.1_Silent_p.G149G|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Silent_p.G128G	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	143	Extracellular (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GGCATCAAGGCGAAGTTCAGA	0.537													T	113853896	T	T	113853896	2	4	231	1	0	0	0	0	0	0	0	1	7444	755	27	1		1	HTR3A	11	113853896	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08	103206355	113853896	21152620	36	16358											
CPNE8	144402	broad.mit.edu	37	chr12	39155951	39155951	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acataatgctctgactgagaTcttgaatgcttgccatactg	8	9	2	3			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr12:39155951T>A	uc001rls.1	-	9	727	c.643A>T	c.(643-645)ATC>TTC	p.I215F		NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	215	C2 2.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CTGACTGAGATCTTGAATGCT	0.308													A	39155951	A	A	39155951	3	1	231	1	0	0	0	0	1	0	0	0	3818	1435	50	5	1099	5	CPNE8	12	39155951	Missense_Mutation	SNP	T	TCGA-32-2615-01A-01D-1495-08		39155951	94695944	37	16359											
KIF21A	55605	broad.mit.edu	37	chr12	39726188	39726188	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tttttgaaagtttctctcgtCtttttgtgagttcctcccgt	7	9	2	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr12:39726188C>A	uc001rly.2	-	21	3025	c.2879G>T	c.(2878-2880)AGA>ATA	p.R960I	KIF21A_uc001rlv.2_5'UTR|KIF21A_uc001rlw.2_Missense_Mutation_p.R277I|KIF21A_uc001rlx.2_Missense_Mutation_p.R947I|KIF21A_uc001rlz.2_Missense_Mutation_p.R924I|KIF21A_uc010skl.1_Missense_Mutation_p.R947I	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	960	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TTTCTCTCGTCTTTTTGTGAG	0.398													A	39726188	A	A	39726188	3	1	231	1	0	0	0	0	1	0	0	0	8288	913	32	5	2217	5	KIF21A	12	39726188	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08	570237	39726188	94125707	38	16360											
GRIP1	23426	broad.mit.edu	37	chr12	66838466	66838466	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgtcttctgttggaattcCattgatggccatcactctgt	9	10	4	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr12:66838466C>T	uc001stk.2	-	12	1670	c.1429G>A	c.(1429-1431)GGA>AGA	p.G477R	GRIP1_uc010sta.1_Missense_Mutation_p.G421R|GRIP1_uc001stj.2_Missense_Mutation_p.G259R|GRIP1_uc001stl.1_Missense_Mutation_p.G369R|GRIP1_uc001stm.2_Missense_Mutation_p.G477R	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	529	PDZ 4.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		GTTGGAATTCCATTGATGGCC	0.458													T	66838466	T	T	66838466	3	4	231	1	0	0	0	0	1	0	0	0	6787	603	21	3	1853	3	GRIP1	12	66838466	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08	27112278	66838466	67013429	39	16361											
OAS2	4939	broad.mit.edu	37	chr12	113435338	113435338	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cccacagtgccagaaaaaaaTcaaggatttaccctcgctgt	7	12	1	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr12:113435338T>A	uc001tuj.2	+	4	781	c.641T>A	c.(640-642)ATC>AAC	p.I214N	OAS2_uc001tui.1_Missense_Mutation_p.I214N	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	214	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						CAGAAAAAAATCAAGGATTTA	0.488													A	113435338	A	A	113435338	3	1	231	1	0	0	0	0	1	0	0	0	10800	1435	50	5	726	5	OAS2	12	113435338	Missense_Mutation	SNP	T	TCGA-32-2615-01A-01D-1495-08	46596872	113435338	20416557	40	16362											
ULK1	8408	broad.mit.edu	37	chr12	132379629	132379629	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatcggccacggcgccttcgCggtggtcttcaagggccgcc	15	15	2	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr12:132379629C>T	uc001uje.2	+	1	351	c.83C>T	c.(82-84)GCG>GTG	p.A28V		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	28	Protein kinase.|ATP (By similarity).				autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		GGCGCCTTCGCGGTGGTCTTC	0.692													T	132379629	T	T	132379629	3	4	231	1	0	0	0	0	1	0	0	0	16972	768	27	1	85	1	ULK1	12	132379629	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08	18944291	132379629	1472266	41	16363											
KLHL1	57626	broad.mit.edu	37	chr13	70314591	70314591	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atactggctacaaatgtccaTtgttgactctgtggatccca	8	10	1	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr13:70314591T>C	uc001vip.2	-	8	2531	c.1737A>G	c.(1735-1737)CAA>CAG	p.Q579Q	KLHL1_uc010thm.1_Silent_p.Q518Q	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	579	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CAAATGTCCATTGTTGACTCT	0.413													C	70314591	C	C	70314591	2	2	231	1	0	0	0	0	0	0	0	1	8365	1490	52	4		4	KLHL1	13	70314591	Silent	SNP	T	TCGA-32-2615-01A-01D-1495-08		70314591	44855287	42	16364											
CLEC14A	161198	broad.mit.edu	37	chr14	38723832	38723832	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccgcagatcacagtccccgaCtttcaccccattgtttgtgc	7	16	2	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr14:38723832C>A	uc001wum.1	-	1	1743	c.1396G>T	c.(1396-1398)GTC>TTC	p.V466F		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	466	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CAGTCCCCGACTTTCACCCCA	0.602													A	38723832	A	A	38723832	3	1	231	1	0	0	0	0	1	0	0	0	3499	565	20	5	80	5	CLEC14A	14	38723832	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08		38723832	68625708	43	16365											
NR2F2	7026	broad.mit.edu	37	chr15	96877485	96877485	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcagcccaacaacatcatggGtatcgagaacatttgcgaac	9	11	1	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr15:96877485G>C	uc010uri.1	+	2	1847	c.623G>C	c.(622-624)GGT>GCT	p.G208A	NR2F2_uc002btp.2_Missense_Mutation_p.G75A|NR2F2_uc010urj.1_Missense_Mutation_p.G55A|NR2F2_uc010urk.1_Missense_Mutation_p.G55A	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	208	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			AACATCATGGGTATCGAGAAC	0.602													C	96877485	C	C	96877485	3	2	231	1	0	0	0	0	1	0	0	0	10628	1261	44	5	676	5	NR2F2	15	96877485	Missense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08		96877485	5653907	44	16366											
CDKN2D	1032	broad.mit.edu	37	chr19	10678076	10678076	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctccagggcgatggcggtGctgccaaacatcatgacctg	13	12	1	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr19:10678076G>A	uc002mpa.2	-	2	461	c.159C>T	c.(157-159)AGC>AGT	p.S53S	KRI1_uc002mox.1_5'Flank|KRI1_uc002moy.1_5'Flank|CDKN2D_uc002mpb.2_Silent_p.S53S	NM_001800	NP_001791	P55273	CDN2D_HUMAN	cyclin-dependent kinase inhibitor 2D	53	ANK 1.				anti-apoptosis|autophagic cell death|cell cycle arrest|DNA synthesis involved in DNA repair|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of caspase activity|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|response to retinoic acid|response to UV|response to vitamin D	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding				0			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CGATGGCGGTGCTGCCAAACA	0.592									Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System				A	10678076	A	A	10678076	2	1	231	1	0	0	0	0	0	0	0	1	3166	1310	46	3		3	CDKN2D	19	10678076	Silent	SNP	G	TCGA-32-2615-01A-01D-1495-08		10678076	48450907	45	16367											
CYP4F11	57834	broad.mit.edu	37	chr19	16025181	16025181	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatgttctcttggtcgaaaCggaaggggtcgtagacctgc	14	8	1	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr19:16025181C>T	uc002nbu.2	-	12	1367	c.1331G>A	c.(1330-1332)CGT>CAT	p.R444H	CYP4F11_uc010eab.1_Silent_p.P422P|CYP4F11_uc002nbt.2_Missense_Mutation_p.R444H	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	444					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						TTGGTCGAAACGGAAGGGGTC	0.587													T	16025181	T	T	16025181	3	4	231	1	0	0	0	0	1	0	0	0	4186	536	19	1	251	1	CYP4F11	19	16025181	Missense_Mutation	SNP	C	TCGA-32-2615-01A-01D-1495-08	5347105	16025181	43103802	46	16368											
HKR1	284459	broad.mit.edu	37	chr19	37853365	37853365	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatagggtccagccctgaacGgagggcagatctagaggaaa	14	8	1	3	rs112164866		TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr19:37853365G>A	uc002ogb.2	+	6	937	c.668G>A	c.(667-669)CGG>CAG	p.R223Q	HKR1_uc002ofx.2_5'UTR|HKR1_uc002ofy.2_5'UTR|HKR1_uc002oga.2_Missense_Mutation_p.R205Q|HKR1_uc010xto.1_Missense_Mutation_p.R205Q|HKR1_uc002ogc.2_Missense_Mutation_p.R204Q|HKR1_uc010xtp.1_Missense_Mutation_p.R162Q|HKR1_uc002ogd.2_Missense_Mutation_p.R162Q	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	223					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGCCCTGAACGGAGGGCAGAT	0.468													A	37853365	A	A	37853365	3	1	231	1	0	0	0	0	1	0	0	0	7194	1116	39	2	682	2	HKR1	19	37853365	Missense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08	21828184	37853365	21275618	47	16369											
CRX	1406	broad.mit.edu	37	chr19	48342915	48342915	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgccatgacctacgccccGgcctccgctttctgctcttc	7	18	2	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr19:48342915G>A	uc002phq.3	+	4	795	c.591G>A	c.(589-591)CCG>CCA	p.P197P		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	197					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P197P(1)		breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		CCTACGCCCCGGCCTCCGCTT	0.672													A	48342915	A	A	48342915	2	1	231	1	0	0	0	0	0	0	0	1	3902	1103	39	2		2	CRX	19	48342915	Silent	SNP	G	TCGA-32-2615-01A-01D-1495-08	10489550	48342915	10786068	48	16370											
R3HDML	140902	broad.mit.edu	37	chr20	42979302	42979302	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtccttttctcttccagggGcaactggattggcgagtccc	12	12	1	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr20:42979302G>A	uc002xls.1	+	5	804	c.632G>A	c.(631-633)GGC>GAC	p.G211D		NM_178491	NP_848586	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like precursor	211						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			TCTTCCAGGGGCAACTGGATT	0.423													A	42979302	A	A	42979302	3	1	231	1	0	0	0	0	1	0	0	0	12889	1203	42	3	650	3	R3HDML	20	42979302	Missense_Mutation	SNP	G	TCGA-32-2615-01A-01D-1495-08		42979302	20046218	49	16371											
MPPED1	758	broad.mit.edu	37	chr22	43831125	43831125	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgaggtgaagaagttcaaCgagtggctgggtaggtccct	16	7	1	2			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chr22:43831125C>T	uc011apv.1	+	3	619	c.396C>T	c.(394-396)AAC>AAT	p.N132N	MPPED1_uc011apw.1_Silent_p.N26N|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Silent_p.N132N|MPPED1_uc011apz.1_Silent_p.N165N	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	132							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				AGAAGTTCAACGAGTGGCTGG	0.682													T	43831125	T	T	43831125	2	4	231	1	0	0	0	0	0	0	0	1	9741	535	19	1		1	MPPED1	22	43831125	Silent	SNP	C	TCGA-32-2615-01A-01D-1495-08		43831125	7473441	50	16372											
SFRS17A	8227	broad.mit.edu	37	chrX	1712915	1712915	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttcggggagatccggaatgTggacatccccatgctggacc	14	11	0	1			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chrX:1712915T>C	uc004cqa.2	+	2	756	c.560T>C	c.(559-561)GTG>GCG	p.V187A	SFRS17A_uc010ncx.1_Missense_Mutation_p.V187A|SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_5'Flank	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	187	RRM.				B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATCCGGAATGTGGACATCCCC	0.607													C	1712915	C	C	1712915	3	2	231	1	0	0	0	0	1	0	0	0	14173	1696	59	4	562	4	SFRS17A	23	1712915	Missense_Mutation	SNP	T	TCGA-32-2615-01A-01D-1495-08		1712915	153557645	51	16373											
ZIC3	7547	broad.mit.edu	37	chrX	136649606	136649606	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctatcaagcaggagctgtcGtgcaagtggatcgacgaggc	14	10	1	0			TCGA-32-2615-01A-01D-1495-08	TCGA-32-2615-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	65e3c804-b1a3-4e21-9407-90a6edc4e290	13640737-743d-4d84-a399-f3dba0539e70	g.chrX:136649606G>A	uc004fak.2	+	1	1261	c.756G>A	c.(754-756)TCG>TCA	p.S252S		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	252	C2H2-type 1; atypical.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AGGAGCTGTCGTGCAAGTGGA	0.607													A	136649606	A	A	136649606	2	1	231	1	0	0	0	0	0	0	0	1	17677	1132	40	1		1	ZIC3	23	136649606	Silent	SNP	G	TCGA-32-2615-01A-01D-1495-08	134936691	136649606	18620954	52	16374											
ABCD3	5825	broad.mit.edu	37	chr1	94953473	94953473	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctaccaaagtggaagaatgcTtttgcgaatgtctcaagctc	9	9	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr1:94953473T>C	uc001dqn.3	+	13	1193	c.1091T>C	c.(1090-1092)CTT>CCT	p.L364P	ABCD3_uc010oto.1_Missense_Mutation_p.L388P|ABCD3_uc010otp.1_Missense_Mutation_p.L291P|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.L52P	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	364	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		GGAAGAATGCTTTTGCGAATG	0.333													C	94953473	C	C	94953473	3	2	232	1	0	0	0	0	1	0	0	0	62	1609	56	4	1172	4	ABCD3	1	94953473	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08		94953473	154297148	1	16375											
NOTCH2	4853	broad.mit.edu	37	chr1	120464949	120464949	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aaccttcaggcagccagagaGagccatgcttacgctttcgt	10	12	1	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr1:120464949G>C	uc001eik.2	-	28	5379	c.5123C>G	c.(5122-5124)TCT>TGT	p.S1708C		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1708	Cytoplasmic (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGCCAGAGAGAGCCATGCTT	0.512			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				C	120464949	C	C	120464949	3	2	232	1	0	0	0	0	1	0	0	0	10548	942	33	5	2320	5	NOTCH2	1	120464949	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	25511476	120464949	128785672	2	16376											
FLG	2312	broad.mit.edu	37	chr1	152278815	152278815	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccctgagtgcctggagccGtctcctgattgttcctcatt	10	13	2	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr1:152278815G>A	uc001ezu.1	-	3	8583	c.8547C>T	c.(8545-8547)GAC>GAT	p.D2849D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2849	Ser-rich.|Filaggrin 17.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGGAGCCGTCTCCTGATT	0.567									Ichthyosis				A	152278815	A	A	152278815	2	1	232	1	0	0	0	0	0	0	0	1	5922	1136	40	1		1	FLG	1	152278815	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	31813866	152278815	96971806	3	16377											
FLG	2312	broad.mit.edu	37	chr1	152280892	152280892	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtgtccagacctatctaccGattgctcttggtgggacccc	10	13	2	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr1:152280892G>A	uc001ezu.1	-	3	6506	c.6470C>T	c.(6469-6471)TCG>TTG	p.S2157L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2157	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTATCTACCGATTGCTCTTG	0.597									Ichthyosis				A	152280892	A	A	152280892	3	1	232	1	0	0	0	0	1	0	0	0	5922	1059	37	2	5719	2	FLG	1	152280892	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	2077	152280892	96969729	4	16378											
SPTA1	6708	broad.mit.edu	37	chr1	158614180	158614180	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aacttgatcacagttcccctGgaacatctatgaggaatcaa	7	10	3	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr1:158614180G>C	uc001fst.1	-	30	4400	c.4201C>G	c.(4201-4203)CAG>GAG	p.Q1401E		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1401	Spectrin 14.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAGTTCCCCTGGAACATCTAT	0.453													C	158614180	C	C	158614180	3	2	232	1	0	0	0	0	1	0	0	0	15115	1357	47	5	3150	5	SPTA1	1	158614180	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	6333288	158614180	90636441	5	16379											
F5	2153	broad.mit.edu	37	chr1	169525893	169525893	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtttcttgccttgcaaatGttttggggtgagagaagata	13	4	1	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr1:169525893G>A	uc001ggg.1	-	6	1088	c.943C>T	c.(943-945)CAT>TAT	p.H315Y	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	315	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCTTGCAAATGTTTTGGGGTG	0.483													A	169525893	A	A	169525893	3	1	232	1	0	0	0	0	1	0	0	0	5348	1377	48	3	5811	3	F5	1	169525893	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	10911713	169525893	79724728	6	16380											
RGL1	23179	broad.mit.edu	37	chr1	183849845	183849845	+	Missense_Mutation	SNP	A	C	C													cttacagaaactgctggattAtctcacacggatgatgccgg							TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr1:183849845A>C	uc001gqo.2	+	5	678	c.521A>C	c.(520-522)TAT>TCT	p.Y174S	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Missense_Mutation_p.Y209S|RGL1_uc010pog.1_Missense_Mutation_p.Y172S|RGL1_uc010poh.1_Missense_Mutation_p.Y172S|RGL1_uc010poi.1_Missense_Mutation_p.Y174S	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	174	N-terminal Ras-GEF.		Y -> S (in a breast cancer sample; somatic mutation).		cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity	p.Y209S(2)		breast(5)|ovary(4)|lung(2)	11						CTGCTGGATTATCTCACACGG	0.498													C	183849845	C	C	183849845	3	2	232	1	0	0	0	0	1	0	0	0	13276	449	16	5	644	5	RGL1	1	183849845	Missense_Mutation	SNP	A	TCGA-32-2632-01A-01D-1495-08	14323952	183849845	65400776	7	16381	19	2									
RGL1	23179	broad.mit.edu	37	chr1	183849848	183849848	+	Missense_Mutation	SNP	T	A	A													acagaaactgctggattatcTcacacggatgatgccgggct							TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr1:183849848T>A	uc001gqo.2	+	5	681	c.524T>A	c.(523-525)CTC>CAC	p.L175H	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Missense_Mutation_p.L210H|RGL1_uc010pog.1_Missense_Mutation_p.L173H|RGL1_uc010poh.1_Missense_Mutation_p.L173H|RGL1_uc010poi.1_Missense_Mutation_p.L175H	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	175	N-terminal Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						CTGGATTATCTCACACGGATG	0.488													A	183849848	A	A	183849848	3	1	232	1	0	0	0	0	1	0	0	0	13276	1551	54	5	647	5	RGL1	1	183849848	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	3	183849848	65400773	8	16382	19	2									
ASPM	259266	broad.mit.edu	37	chr1	197112574	197112574	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tacagctttctcattaaaagAaacttttgaaacgttggcac	6	8	1	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr1:197112574A>G	uc001gtu.2	-	3	1065	c.808T>C	c.(808-810)TCT>CCT	p.S270P	ASPM_uc001gtv.2_Missense_Mutation_p.S270P|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	270					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TCATTAAAAGAAACTTTTGAA	0.378													G	197112574	G	G	197112574	3	3	232	1	0	0	0	0	1	0	0	0	1056	246	9	4	9729	4	ASPM	1	197112574	Missense_Mutation	SNP	A	TCGA-32-2632-01A-01D-1495-08	13262726	197112574	52138047	9	16383											
PUM2	23369	broad.mit.edu	37	chr2	20482930	20482930	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggctgagtgccaattggccGaaacagaccatttgtgctgc	12	10	0	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:20482930G>A	uc002rds.1	-	11	1521	c.1498C>T	c.(1498-1500)CGG>TGG	p.R500W	PUM2_uc002rdt.1_Missense_Mutation_p.R500W|PUM2_uc002rdr.2_Missense_Mutation_p.R439W|PUM2_uc010yjy.1_Missense_Mutation_p.R500W|PUM2_uc002rdu.1_Missense_Mutation_p.R500W|PUM2_uc010yjz.1_Missense_Mutation_p.R439W	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	500					regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAATTGGCCGAAACAGACCA	0.453													A	20482930	A	A	20482930	3	1	232	1	0	0	0	0	1	0	0	0	12826	1057	37	2	1736	2	PUM2	2	20482930	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08		20482930	222716443	10	16384											
QPCT	25797	broad.mit.edu	37	chr2	37599531	37599531	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atgaattgggtttgctcaagGatcactctttggaggggcgg	15	6	3	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:37599531G>A	uc002rqg.2	+	6	978	c.856G>A	c.(856-858)GAT>AAT	p.D286N	QPCT_uc002rqh.2_Missense_Mutation_p.D237N	NM_012413	NP_036545	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase precursor	286					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)	1		Ovarian(717;0.051)|all_hematologic(82;0.21)				TTTGCTCAAGGATCACTCTTT	0.328													A	37599531	A	A	37599531	3	1	232	1	0	0	0	0	1	0	0	0	12874	1174	41	3	878	3	QPCT	2	37599531	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	17116601	37599531	205599842	11	16385											
SLC5A7	60482	broad.mit.edu	37	chr2	108614387	108614387	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtacacactggtgggagggcTctattctgtggcctacactg	13	10	2	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:108614387T>A	uc002tdv.2	+	5	818	c.542T>A	c.(541-543)CTC>CAC	p.L181H	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.L181H|SLC5A7_uc010ywn.1_Missense_Mutation_p.L68H	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	181	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GTGGGAGGGCTCTATTCTGTG	0.473													A	108614387	A	A	108614387	3	1	232	1	0	0	0	0	1	0	0	0	14670	1551	54	5	556	5	SLC5A7	2	108614387	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	71014856	108614387	134584986	12	16386											
CNTNAP5	129684	broad.mit.edu	37	chr2	125530385	125530385	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccggtttcagctccttcagAgatcacctttgccatcgatg	8	13	3	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:125530385A>G	uc002tno.2	+	17	2904	c.2540A>G	c.(2539-2541)GAG>GGG	p.E847G	CNTNAP5_uc010flu.2_Missense_Mutation_p.E848G	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	847	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCTCCTTCAGAGATCACCTTT	0.488													G	125530385	G	G	125530385	3	3	232	1	0	0	0	0	1	0	0	0	3650	304	11	4	2606	4	CNTNAP5	2	125530385	Missense_Mutation	SNP	A	TCGA-32-2632-01A-01D-1495-08	16915998	125530385	117668988	13	16387											
SCN7A	6332	broad.mit.edu	37	chr2	167273364	167273364	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacctttctccacttgttggGtcaatgcattcatagaatct	6	10	4	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:167273364G>A	uc002udu.1	-	20	3394	c.3267C>T	c.(3265-3267)GAC>GAT	p.D1089D	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1089					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						CACTTGTTGGGTCAATGCATT	0.398													A	167273364	A	A	167273364	2	1	232	1	0	0	0	0	0	0	0	1	13923	1252	44	3		3	SCN7A	2	167273364	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	41742979	167273364	75926009	14	16388											
TTN	7273	broad.mit.edu	37	chr2	179453519	179453519	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccaaaccacagtcatctctTctttgcttactttagtgact	4	12	3	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:179453519T>C	uc010zfg.1	-	253	55453	c.55229A>G	c.(55228-55230)GAA>GGA	p.E18410G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E12105G|TTN_uc010zfi.1_Missense_Mutation_p.E12038G|TTN_uc010zfj.1_Missense_Mutation_p.E11913G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19337							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTCATCTCTTCTTTGCTTAC	0.438													C	179453519	C	C	179453519	3	2	232	1	0	0	0	0	1	0	0	0	16732	1783	62	4	45282	4	TTN	2	179453519	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	12180155	179453519	63745854	15	16389											
TTN	7273	broad.mit.edu	37	chr2	179522849	179522849	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tttgggtggagccacgggaaTttctttttctgcggcttctt	12	8	3	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:179522849T>A	uc010zfk.1	-	29	2571	c.2023A>T	c.(2023-2025)ATT>TTT	p.I675F	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCACGGGAATTTCTTTTTCT	0.413													A	179522849	A	A	179522849	3	1	232	1	0	0	0	0	1	0	0	0	16732	1508	52	5		5	TTN	2	179522849	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	69330	179522849	63676524	16	16390											
STAT1	6772	broad.mit.edu	37	chr2	191862990	191862990	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcttcttgagtaacagctGttcttgtttctgatcactct	6	10	6	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:191862990G>A	uc002usj.2	-	8	974	c.586C>T	c.(586-588)CAG>TAG	p.Q196*	STAT1_uc010fse.1_Nonsense_Mutation_p.Q196*|STAT1_uc002usk.2_Nonsense_Mutation_p.Q196*|STAT1_uc002usl.2_Nonsense_Mutation_p.Q198*|STAT1_uc010fsf.1_Intron	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	196					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	AGTAACAGCTGTTCTTGTTTC	0.343													A	191862990	A	A	191862990	4	1	232	1	0	0	0	0	0	1	0	0	15263	1386	48	3	1742	3	STAT1	2	191862990	Nonsense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	12340141	191862990	51336383	17	16391											
STAT4	6775	broad.mit.edu	37	chr2	191926501	191926501	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggttttaagtaccaacggccTctgagggtgggttggcatac	14	8	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:191926501T>C	uc002usm.1	-	10	1242	c.988A>G	c.(988-990)AGG>GGG	p.R330G	STAT4_uc002usn.1_Missense_Mutation_p.R330G|STAT4_uc010zgk.1_Missense_Mutation_p.R175G|STAT4_uc002uso.2_Missense_Mutation_p.R330G	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	330					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			ACCAACGGCCTCTGAGGGTGG	0.403													C	191926501	C	C	191926501	3	2	232	1	0	0	0	0	1	0	0	0	15266	1550	54	4	1318	4	STAT4	2	191926501	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	63511	191926501	51272872	18	16392											
SPHKAP	80309	broad.mit.edu	37	chr2	228883868	228883868	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acccagaccacagacagccaCggcactggccacctgagtca	9	17	1	3	rs149295795	by1000genomes	TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr2:228883868C>T	uc002vpq.2	-	7	1749	c.1702G>A	c.(1702-1704)GTG>ATG	p.V568M	SPHKAP_uc002vpp.2_Missense_Mutation_p.V568M|SPHKAP_uc010zlx.1_Missense_Mutation_p.V568M	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	568						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAGACAGCCACGGCACTGGCC	0.562													T	228883868	T	T	228883868	3	4	232	1	0	0	0	0	1	0	0	0	15047	536	19	1	3424	1	SPHKAP	2	228883868	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	36957367	228883868	14315505	19	16393											
C3orf45	132228	broad.mit.edu	37	chr3	50324238	50324238	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggagggttcctgctgctgctCgcgctgctggtgctcacttg	15	12	1	0	rs116862338	by1000genomes	TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr3:50324238C>T	uc003cyz.2	+	3	333	c.306C>T	c.(304-306)CTC>CTT	p.L102L		NM_153215	NP_694947	Q8N112	CC045_HUMAN	hypothetical protein LOC132228	102	Helical; (Potential).					integral to membrane				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TGCTGCTGCTCGCGCTGCTGG	0.617													T	50324238	T	T	50324238	2	4	232	1	0	0	0	0	0	0	0	1	2231	871	31	2		2	C3orf45	3	50324238	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08		50324238	147698192	20	16394											
STAB1	23166	broad.mit.edu	37	chr3	52540843	52540843	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcctgcccaagcactgcagcGaggagcagcacaagattgtg	12	12	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr3:52540843G>A	uc003dej.2	+	18	2040	c.1966G>A	c.(1966-1968)GAG>AAG	p.E656K	STAB1_uc003dei.1_Missense_Mutation_p.E656K	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	656	Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCACTGCAGCGAGGAGCAGCA	0.642													A	52540843	A	A	52540843	3	1	232	1	0	0	0	0	1	0	0	0	15236	1059	37	2	2036	2	STAB1	3	52540843	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	2216605	52540843	145481587	21	16395											
C3orf67	200844	broad.mit.edu	37	chr3	58856003	58856003	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcttgatttttactgttccGtgtaatacttgttcctctgt	6	8	2	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr3:58856003G>A	uc003dkt.1	-	8	782	c.373C>T	c.(373-375)CGG>TGG	p.R125W	C3orf67_uc003dks.1_5'Flank|uc003dku.1_Intron|C3orf67_uc003dkv.1_Translation_Start_Site|C3orf67_uc003dkw.2_Missense_Mutation_p.R33W	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	125											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		TTACTGTTCCGTGTAATACTT	0.378													A	58856003	A	A	58856003	3	1	232	1	0	0	0	0	1	0	0	0	2241	1144	40	1	1354	1	C3orf67	3	58856003	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	6315160	58856003	139166427	22	16396											
TBC1D23	55773	broad.mit.edu	37	chr3	100002647	100002648	+	Frame_Shift_Ins	INS	-	A	A													atgccataatgaataagtacINSattcccaggtaaaatatgat							TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr3:100002647_100002648insA	uc003dtt.2	+	4	645_646	c.468_469insA	c.(466-471)TACATTfs	p.Y156fs	TBC1D23_uc003dts.2_Frame_Shift_Ins_p.Y156fs	NM_018309	NP_060779	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	156_157	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)|liver(1)	2						TGAATAAGTACATTCCCAGGTA	0.381													A	100002648	A	A	100002647	7	5	232	1	0	1	1	0	0	0	0	0	15610	489	17	0	482	0	TBC1D23	3	100002647	Frame_Shift_Ins	INS	-	TCGA-32-2632-01A-01D-1495-08	41146644	100002647	98019783	23	16397											
KIAA1524	57650	broad.mit.edu	37	chr3	108279495	108279495	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aattgctattttttcactcaCcaccattccagactgaagtt	4	11	2	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr3:108279495C>T	uc003dxb.3	-	14	2096	c.1827_splice	c.e14+1	p.V609_splice		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen							cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TTTTCACTCACCACCATTCCA	0.328													T	108279495	T	T	108279495	5	4	232	1	0	0	0	0	0	0	1	0	8239	521	18	3	921	3	KIAA1524	3	108279495	Splice_Site	SNP	C	TCGA-32-2632-01A-01D-1495-08	8276848	108279495	89742935	24	16398											
PRR23C	389152	broad.mit.edu	37	chr3	138762829	138762829	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttccaggtcgaagatggggcGtggagagcgtctctctgaac	15	9	2	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr3:138762829G>A	uc011bmt.1	-	1	906	c.634C>T	c.(634-636)CGC>TGC	p.R212C		NM_001134657	NP_001128129	Q6ZRP0	PR23C_HUMAN	proline rich 23C	212	Pro-rich.									skin(1)	1						AAGATGGGGCGTGGAGAGCGT	0.647													A	138762829	A	A	138762829	3	1	232	1	0	0	0	0	1	0	0	0	12596	1145	40	1	158	1	PRR23C	3	138762829	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	30483334	138762829	59259601	25	16399											
LEKR1	389170	broad.mit.edu	37	chr3	156763371	156763371	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccaaattcccaacctgcgCggggtgtcaaaacccaccac	7	16	1	0	rs144318565		TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr3:156763371C>T	uc003fba.1	+	14	2334	c.999C>T	c.(997-999)CGC>CGT	p.R333R		NM_001004316	NP_001004316	Q6ZMV7	LEKR1_HUMAN	leucine, glutamate and lysine rich 1	Error:Variant_position_missing_in_D3DNK7_after_alignment											0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CCAACCTGCGCGGGGTGTCAA	0.552													T	156763371	T	T	156763371	2	4	232	1	0	0	0	0	0	0	0	1	8717	755	27	1		1	LEKR1	3	156763371	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08	18000542	156763371	41259059	26	16400											
C4orf23	152992	broad.mit.edu	37	chr4	8472818	8472818	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtttttccacagagagcctAtctctggcagaagtagccaa	9	11	1	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr4:8472818A>G	uc003glg.1	+	10	1436	c.1248A>G	c.(1246-1248)CTA>CTG	p.L416L	C4orf23_uc003glh.1_Silent_p.L253L|C4orf23_uc003gli.1_5'Flank	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	645					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						CAGAGAGCCTATCTCTGGCAG	0.532													G	8472818	G	G	8472818	2	3	232	1	0	0	0	0	0	0	0	1	2256	436	16	4		4	C4orf23	4	8472818	Silent	SNP	A	TCGA-32-2632-01A-01D-1495-08		8472818	182681458	27	16401											
GPR78	27201	broad.mit.edu	37	chr4	8588808	8588808	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagctcgtgcccttcgtcacCgtgaacgcccagtggggcat	13	14	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr4:8588808C>T	uc003glk.2	+	3	1229	c.810C>T	c.(808-810)ACC>ACT	p.T270T	CPZ_uc003gll.2_Intron	NM_080819	NP_543009	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	270	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|ovary(2)	6						CCTTCGTCACCGTGAACGCCC	0.662													T	8588808	T	T	8588808	2	4	232	1	0	0	0	0	0	0	0	1	6710	639	23	2		2	GPR78	4	8588808	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08	115990	8588808	182565468	28	16402											
CENPE	1062	broad.mit.edu	37	chr4	104044141	104044141	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcaatgtttggtagttttTaaatagtttttcatttttct	5	4	3	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr4:104044141T>C	uc003hxb.1	-	43	7120	c.7030A>G	c.(7030-7032)AAA>GAA	p.K2344E	CENPE_uc003hxc.1_Missense_Mutation_p.K2223E	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	2344	Kinetochore-binding domain.|Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TGGTAGTTTTTAAATAGTTTT	0.378													C	104044141	C	C	104044141	3	2	232	1	0	0	0	0	1	0	0	0	3230	1763	61	4	1103	4	CENPE	4	104044141	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	95455333	104044141	87110135	29	16403											
ING2	3622	broad.mit.edu	37	chr4	184431464	184431464	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aggaaattgatgatgtctacGaaaaatataagaaagaagat	9	2	1	5			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr4:184431464G>A	uc003ivs.1	+	2	331	c.202G>A	c.(202-204)GAA>AAA	p.E68K	ING2_uc011ckk.1_Missense_Mutation_p.E28K	NM_001564	NP_001555	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	68	Potential.				chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding			ovary(1)	1		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		TGATGTCTACGAAAAATATAA	0.318													A	184431464	A	A	184431464	3	1	232	1	0	0	0	0	1	0	0	0	7736	1059	37	2	208	2	ING2	4	184431464	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	80387323	184431464	6722812	30	16404											
SLC6A18	348932	broad.mit.edu	37	chr5	1244741	1244741	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggttctgcgatgacattgcGtggatgaccgggaggcggcc	17	9	1	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:1244741G>A	uc003jby.1	+	11	1638	c.1515G>A	c.(1513-1515)GCG>GCA	p.A505A		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	505	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ATGACATTGCGTGGATGACCG	0.612													A	1244741	A	A	1244741	2	1	232	1	0	0	0	0	0	0	0	1	14681	1132	40	1		1	SLC6A18	5	1244741	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08		1244741	179670519	31	16405											
BASP1	10409	broad.mit.edu	37	chr5	17275800	17275800	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcgcccgcagctcctgccGcccaggagaccaaaagtgac	12	16	0	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:17275800G>A	uc003jfx.2	+	2	654	c.475G>A	c.(475-477)GCC>ACC	p.A159T		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	159					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						AGCTCCTGCCGCCCAGGAGAC	0.522													A	17275800	A	A	17275800	3	1	232	1	0	0	0	0	1	0	0	0	1317	1087	38	1	477	1	BASP1	5	17275800	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	16031059	17275800	163639460	32	16406											
DDX4	54514	broad.mit.edu	37	chr5	55083676	55083676	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcaacttaacttctaggcGgcttttctcctaccaatttt	5	11	2	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:55083676G>A	uc003jqg.3	+	15	1094	c.1020G>A	c.(1018-1020)GCG>GCA	p.A340A	DDX4_uc010ivz.2_Silent_p.A320A|DDX4_uc003jqh.3_Silent_p.A306A|DDX4_uc003jqj.2_Silent_p.A191A	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	340	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				ACTTCTAGGCGGCTTTTCTCC	0.383													A	55083676	A	A	55083676	2	1	232	1	0	0	0	0	0	0	0	1	4360	1103	39	2		2	DDX4	5	55083676	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	37807876	55083676	125831584	33	16407											
DMGDH	29958	broad.mit.edu	37	chr5	78340364	78340364	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatcattttacctacttcacGagcccaaaatccttaaacaa	2	12	2	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:78340364G>A	uc003kfs.2	-	6	763	c.757C>T	c.(757-759)CGT>TGT	p.R253C	DMGDH_uc011cte.1_Missense_Mutation_p.R103C|DMGDH_uc011ctf.1_Missense_Mutation_p.R52C|DMGDH_uc011ctg.1_Intron	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	253					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		CCTACTTCACGAGCCCAAAAT	0.318													A	78340364	A	A	78340364	3	1	232	1	0	0	0	0	1	0	0	0	4581	1058	37	2	1887	2	DMGDH	5	78340364	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	23256688	78340364	102574896	34	16408											
FAM81B	153643	broad.mit.edu	37	chr5	94749817	94749817	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atggctttcgaaaagaggaaTcgctcgccaggaagttactg	12	8	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:94749817T>A	uc003kla.1	+	4	506	c.460T>A	c.(460-462)TCG>ACG	p.S154T	FAM81B_uc010jbe.1_5'UTR	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	154										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		AAAAGAGGAATCGCTCGCCAG	0.478													A	94749817	A	A	94749817	3	1	232	1	0	0	0	0	1	0	0	0	5629	1435	50	5	474	5	FAM81B	5	94749817	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	16409453	94749817	86165443	35	16409											
RAPGEF6	51735	broad.mit.edu	37	chr5	130940379	130940379	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaagataagaataaatagtaTttaagtcctgtggaacagaa	9	3	0	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:130940379T>A	uc003kvn.1	-	2	283	c.77A>T	c.(76-78)AAT>ATT	p.N26I	RAPGEF6_uc003kvp.1_Missense_Mutation_p.N76I|RAPGEF6_uc003kvo.1_Missense_Mutation_p.N26I|RAPGEF6_uc010jdi.1_Missense_Mutation_p.N26I|RAPGEF6_uc010jdj.1_Missense_Mutation_p.N26I|RAPGEF6_uc003kvr.2_Missense_Mutation_p.N26I|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.N26I	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	26					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		ATAAATAGTATTTAAGTCCTG	0.318													A	130940379	A	A	130940379	3	1	232	1	0	0	0	0	1	0	0	0	13048	1493	52	5	5322	5	RAPGEF6	5	130940379	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	36190562	130940379	49974881	36	16410											
FBXO38	81545	broad.mit.edu	37	chr5	147796556	147796556	+	Splice_Site	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgtgttttggttttgccttaGggttgtgctcgagttggtct	14	5	1	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:147796556G>C	uc003lpf.1	+	12	1528	c.1408_splice	c.e12-1	p.G470_splice	FBXO38_uc003lpg.1_Splice_Site_p.G470_splice|FBXO38_uc003lph.2_Splice_Site_p.G470_splice	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b							cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTGCCTTAGGGTTGTGCTC	0.363													C	147796556	C	C	147796556	5	2	232	1	0	0	0	0	0	0	1	0	5746	1014	35	5	1449	5	FBXO38	5	147796556	Splice_Site	SNP	G	TCGA-32-2632-01A-01D-1495-08	16856177	147796556	33118704	37	16411											
FBXO38	81545	broad.mit.edu	37	chr5	147796638	147796638	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gcaaccagaactccaacaatGacgataataatgcccagaat	6	11	0	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:147796638G>C	uc003lpf.1	+	12	1609	c.1489G>C	c.(1489-1491)GAC>CAC	p.D497H	FBXO38_uc003lpg.1_Missense_Mutation_p.D497H|FBXO38_uc003lph.2_Missense_Mutation_p.D497H	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	497						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCAACAATGACGATAATAA	0.453													C	147796638	C	C	147796638	3	2	232	1	0	0	0	0	1	0	0	0	5746	1290	45	5	1531	5	FBXO38	5	147796638	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	82	147796638	33118622	38	16412											
NIPAL4	348938	broad.mit.edu	37	chr5	156890242	156890242	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actatggcttctacatcggcCtgggcctggcattcctgtct	10	13	2	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:156890242C>G	uc003lwx.3	+	2	480	c.364C>G	c.(364-366)CTG>GTG	p.L122V	ADAM19_uc003lww.1_Intron|NIPAL4_uc011ddq.1_Missense_Mutation_p.L122V|NIPAL4_uc010jin.1_Silent_p.A56A	NM_001099287	NP_001092757	Q0D2K0	NIPA4_HUMAN	ichthyin protein	122	Helical; (Potential).					integral to membrane	receptor activity				0						CTACATCGGCCTGGGCCTGGC	0.577													G	156890242	G	G	156890242	3	3	232	1	0	0	0	0	1	0	0	0	10427	680	24	5	370	5	NIPAL4	5	156890242	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	9093604	156890242	24025018	39	16413											
GABRA1	2554	broad.mit.edu	37	chr5	161324318	161324318	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagtgtcagcaaaattgacCgactgtcaagaatagccttc	8	10	2	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr5:161324318C>T	uc010jiw.2	+	11	1729	c.1261C>T	c.(1261-1263)CGA>TGA	p.R421*	GABRA1_uc010jix.2_Nonsense_Mutation_p.R421*|GABRA1_uc010jiy.2_Nonsense_Mutation_p.R421*|GABRA1_uc003lyx.3_Nonsense_Mutation_p.R421*|GABRA1_uc010jiz.2_Nonsense_Mutation_p.R421*|GABRA1_uc010jja.2_Nonsense_Mutation_p.R421*|GABRA1_uc010jjb.2_Nonsense_Mutation_p.R421*	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	421	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CAAAATTGACCGACTGTCAAG	0.443													T	161324318	T	T	161324318	4	4	232	1	0	0	0	0	0	1	0	0	6160	644	23	2	1295	2	GABRA1	5	161324318	Nonsense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	4434076	161324318	19590942	40	16414											
MCHR2	84539	broad.mit.edu	37	chr6	100382322	100382322	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctcccaagtatagcataaaAttaaaatatagcacaccaaa	3	9	1	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr6:100382322A>G	uc003pqh.1	-	5	974	c.659T>C	c.(658-660)ATT>ACT	p.I220T	MCHR2_uc003pqi.1_Missense_Mutation_p.I220T	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	220	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		ATAGCATAAAATTAAAATATA	0.279													G	100382322	G	G	100382322	3	3	232	1	0	0	0	0	1	0	0	0	9383	101	4	4	371	4	MCHR2	6	100382322	Missense_Mutation	SNP	A	TCGA-32-2632-01A-01D-1495-08		100382322	70732745	41	16415											
MCHR2	84539	broad.mit.edu	37	chr6	100395726	100395726	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gatggtgcagagaggcccccCaaacacccactctccccctc	8	19	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr6:100395726C>A	uc003pqh.1	-	3	619	c.304G>T	c.(304-306)GGG>TGG	p.G102W	MCHR2_uc003pqi.1_Missense_Mutation_p.G102W	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	102	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		AGAGGCCCCCCAAACACCCAC	0.488													A	100395726	A	A	100395726	3	1	232	1	0	0	0	0	1	0	0	0	9383	594	21	5	734	5	MCHR2	6	100395726	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	13404	100395726	70719341	42	16416											
HDAC2	3066	broad.mit.edu	37	chr6	114265495	114265495	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttcatctccactgtcttcatGaacagcatcttctggaatag	6	11	6	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr6:114265495G>C	uc003pwd.1	-	11	1453	c.1453C>G	c.(1453-1455)CAT>GAT	p.H485D	HDAC2_uc003pwc.1_Missense_Mutation_p.H361D|HDAC2_uc003pwe.1_Missense_Mutation_p.H361D	NM_001527	NP_001518	Q92769	HDAC2_HUMAN	histone deacetylase 2	391					blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			skin(2)|ovary(1)|central_nervous_system(1)	4		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	CTGTCTTCATGAACAGCATCT	0.363													C	114265495	C	C	114265495	3	2	232	1	0	0	0	0	1	0	0	0	7007	1290	45	5	311	5	HDAC2	6	114265495	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	13869769	114265495	56849572	43	16417											
MAP7	9053	broad.mit.edu	37	chr6	136682257	136682257	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttccagcctgcgcgactcCtcctcacggcgagtcgtcct	10	18	1	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr6:136682257C>T	uc003qgz.2	-	12	1833	c.1587G>A	c.(1585-1587)GAG>GAA	p.E529E	MAP7_uc011edf.1_Silent_p.E514E|MAP7_uc011edg.1_Silent_p.E559E|MAP7_uc010kgu.2_Silent_p.E551E|MAP7_uc011edh.1_Silent_p.E514E|MAP7_uc010kgv.2_Silent_p.E551E|MAP7_uc010kgs.2_Silent_p.E383E|MAP7_uc011edi.1_Silent_p.E383E|MAP7_uc010kgq.1_Silent_p.E435E|MAP7_uc003qha.1_Silent_p.E492E	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	529	Potential.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		TGCGCGACTCCTCCTCACGGC	0.617													T	136682257	T	T	136682257	2	4	232	1	0	0	0	0	0	0	0	1	9266	680	24	3		3	MAP7	6	136682257	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08	22416762	136682257	34432810	44	16418											
KIAA0415	9907	broad.mit.edu	37	chr7	4820908	4820908	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctcgactccctgcagaggctCttcctcatcatctcagccac	6	18	4	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:4820908C>T	uc003sne.2	+	2	227	c.144C>T	c.(142-144)CTC>CTT	p.L48L	KIAA0415_uc010ksp.2_RNA	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	48					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		TGCAGAGGCTCTTCCTCATCA	0.632													T	4820908	T	T	4820908	2	4	232	1	0	0	0	0	0	0	0	1	8175	900	32	3		3	KIAA0415	7	4820908	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08		4820908	154317755	45	16419											
ABCB5	340273	broad.mit.edu	37	chr7	20744386	20744386	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaaggaaaacagcacaggaGgcttgacaacaatattagcc	9	8	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:20744386G>A	uc003suw.3	+	11	1588	c.1042G>A	c.(1042-1044)GGC>AGC	p.G348S	ABCB5_uc010kuh.2_Missense_Mutation_p.G793S	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	348	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CAGCACAGGAGGCTTGACAAC	0.328													A	20744386	A	A	20744386	3	1	232	1	0	0	0	0	1	0	0	0	44	1000	35	3	2492	3	ABCB5	7	20744386	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	15923478	20744386	138394277	46	16420											
CHN2	1124	broad.mit.edu	37	chr7	29539600	29539600	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacaacacttgtgaaggctcAcaacactcagagacccatgg	8	13	2	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:29539600A>C	uc003szz.2	+	9	1294	c.857A>C	c.(856-858)CAC>CCC	p.H286P	CHN2_uc011jzs.1_Missense_Mutation_p.H361P|CHN2_uc010kva.2_Missense_Mutation_p.H56P|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Missense_Mutation_p.H251P|CHN2_uc011jzt.1_Missense_Mutation_p.H299P|CHN2_uc010kvd.2_Missense_Mutation_p.H142P|CHN2_uc011jzu.1_Missense_Mutation_p.H271P|CHN2_uc010kvg.2_Missense_Mutation_p.H150P|CHN2_uc010kvh.2_Intron|CHN2_uc010kvi.2_Missense_Mutation_p.H150P|CHN2_uc010kve.2_Missense_Mutation_p.H150P|CHN2_uc003taa.2_Missense_Mutation_p.H150P|CHN2_uc010kvf.2_Intron|CHN2_uc010kvj.2_Missense_Mutation_p.H105P|CHN2_uc010kvk.2_Intron|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Missense_Mutation_p.H105P|CHN2_uc011jzv.1_Missense_Mutation_p.H79P	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	286	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						GTGAAGGCTCACAACACTCAG	0.413													C	29539600	C	C	29539600	3	2	232	1	0	0	0	0	1	0	0	0	3363	159	6	5	1059	5	CHN2	7	29539600	Missense_Mutation	SNP	A	TCGA-32-2632-01A-01D-1495-08	8795214	29539600	129599063	47	16421											
CCDC129	223075	broad.mit.edu	37	chr7	31682400	31682400	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggactgtcagctagagtcGgatgggccagattccaaaag	13	9	1	2	rs146986060		TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:31682400G>A	uc003tcj.1	+	11	2409	c.1416G>A	c.(1414-1416)TCG>TCA	p.S472S	CCDC129_uc011kad.1_Silent_p.S482S|CCDC129_uc003tci.1_Silent_p.S323S|CCDC129_uc011kae.1_Silent_p.S498S|CCDC129_uc003tck.1_Silent_p.S380S	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	472											0						AGCTAGAGTCGGATGGGCCAG	0.502													A	31682400	A	A	31682400	2	1	232	1	0	0	0	0	0	0	0	1	2764	1103	39	2		2	CCDC129	7	31682400	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	2142800	31682400	127456263	48	16422											
EGFR	1956	broad.mit.edu	37	chr7	55210075	55210075	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caataactgtgaggtggtccTtgggaatttggaaattacct	11	6	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:55210075T>G	uc003tqk.2	+	2	431	c.185T>G	c.(184-186)CTT>CGT	p.L62R	EGFR_uc003tqh.2_Missense_Mutation_p.L62R|EGFR_uc003tqi.2_Missense_Mutation_p.L62R|EGFR_uc003tqj.2_Missense_Mutation_p.L62R|EGFR_uc010kzg.1_Missense_Mutation_p.L62R|EGFR_uc011kco.1_Missense_Mutation_p.L9R	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	62	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.L62R(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAGGTGGTCCTTGGGAATTTG	0.408		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			G	55210075	G	G	55210075	3	3	232	1	0	0	0	0	1	0	0	0	4967	1609	56	5	191	5	EGFR	7	55210075	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	23527675	55210075	103928588	49	16423											
CALN1	83698	broad.mit.edu	37	chr7	71275350	71275350	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actctgtttggcagttccccGaggtctcattcaggctctct	9	13	4	0	rs143545775		TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:71275350G>A	uc003twa.3	-	5	1030	c.503C>T	c.(502-504)TCG>TTG	p.S168L	CALN1_uc003twb.3_Missense_Mutation_p.S210L|CALN1_uc003twc.3_Missense_Mutation_p.S168L	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	168	Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding	p.S168L(1)		skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				GCAGTTCCCCGAGGTCTCATT	0.507													A	71275350	A	A	71275350	3	1	232	1	0	0	0	0	1	0	0	0	2591	1059	37	2	164	2	CALN1	7	71275350	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	16065275	71275350	87863313	50	16424											
PIK3CG	5294	broad.mit.edu	37	chr7	106508826	106508826	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacaggattttgtgctgcgcGtctgtggccgggatgagtac	15	8	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:106508826G>A	uc003vdv.3	+	2	905	c.820G>A	c.(820-822)GTC>ATC	p.V274I	PIK3CG_uc003vdu.2_Missense_Mutation_p.V274I|PIK3CG_uc003vdw.2_Missense_Mutation_p.V274I	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	274					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TGTGCTGCGCGTCTGTGGCCG	0.542													A	106508826	A	A	106508826	3	1	232	1	0	0	0	0	1	0	0	0	11916	1145	40	1	822	1	PIK3CG	7	106508826	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	35233476	106508826	52629837	51	16425											
PIK3CG	5294	broad.mit.edu	37	chr7	106509352	106509352	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagcaaggcctctgcagagtCccccagttctgagtccaagg	11	14	2	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:106509352C>T	uc003vdv.3	+	2	1431	c.1346C>T	c.(1345-1347)TCC>TTC	p.S449F	PIK3CG_uc003vdu.2_Missense_Mutation_p.S449F|PIK3CG_uc003vdw.2_Missense_Mutation_p.S449F	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	449					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TCTGCAGAGTCCCCCAGTTCT	0.517													T	106509352	T	T	106509352	3	4	232	1	0	0	0	0	1	0	0	0	11916	855	30	3	1348	3	PIK3CG	7	106509352	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	526	106509352	52629311	52	16426											
GCC1	79571	broad.mit.edu	37	chr7	127222169	127222169	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gatagtcagtatggctgtgaGagtctgctggcggcccaggg	17	8	2	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:127222169G>C	uc003vma.2	-	2	2645	c.2227C>G	c.(2227-2229)CTC>GTC	p.L743V		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	743	Potential.|GRIP.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						ATGGCTGTGAGAGTCTGCTGG	0.542													C	127222169	C	C	127222169	3	2	232	1	0	0	0	0	1	0	0	0	6285	942	33	5	104	5	GCC1	7	127222169	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	20712817	127222169	31916494	53	16427											
MGAM	8972	broad.mit.edu	37	chr7	141736628	141736628	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctatttcctcccaggaccaGgatcctgcctcctttggagc	8	16	0	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:141736628G>T	uc003vwy.2	+	18	2136	c.2082G>T	c.(2080-2082)CAG>CAT	p.Q694H		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	694	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCCAGGACCAGGATCCTGCCT	0.483													T	141736628	T	T	141736628	3	4	232	1	0	0	0	0	1	0	0	0	9541	991	35	5	2148	5	MGAM	7	141736628	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	14514459	141736628	17402035	54	16428											
CNTNAP2	26047	broad.mit.edu	37	chr7	146825878	146825878	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaagcatcaactacaatggcGtcaacattactgatcttgcc	6	11	3	1	rs145832489		TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:146825878G>A	uc003weu.1	+	7	1549	c.1033G>A	c.(1033-1035)GTC>ATC	p.V345I		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	345	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTACAATGGCGTCAACATTAC	0.413										HNSCC(39;0.1)			A	146825878	A	A	146825878	3	1	232	1	0	0	0	0	1	0	0	0	3647	1145	40	1	1059	1	CNTNAP2	7	146825878	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	5089250	146825878	12312785	55	16429											
SSPO	23145	broad.mit.edu	37	chr7	149517991	149517991	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagcaggatggtggctgcGtgccaattgggcactgtgac	17	8	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr7:149517991G>A	uc010lpk.2	+	88	12334	c.12334G>A	c.(12334-12336)GTG>ATG	p.V4112M	SSPO_uc010lpm.1_5'Flank|SSPO_uc003wgg.2_5'Flank|SSPO_uc003wgh.2_5'Flank|SSPO_uc003wgi.1_5'Flank	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4112					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGGTGGCTGCGTGCCAATTGG	0.667													A	149517991	A	A	149517991	3	1	232	1	0	0	0	0	1	0	0	0	15188	1145	40	1	12674	1	SSPO	7	149517991	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	2692113	149517991	9620672	56	16430											
DOCK5	80005	broad.mit.edu	37	chr8	25159899	25159899	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttgtgtgccagattgtccGcgtgggccatatggagctga	14	10	0	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr8:25159899G>A	uc003xeg.2	+	10	1042	c.905G>A	c.(904-906)CGC>CAC	p.R302H	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.R16H|DOCK5_uc003xef.2_Missense_Mutation_p.R302H	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	302						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CAGATTGTCCGCGTGGGCCAT	0.562													A	25159899	A	A	25159899	3	1	232	1	0	0	0	0	1	0	0	0	4690	1087	38	1	943	1	DOCK5	8	25159899	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08		25159899	121204123	57	16431											
DOCK5	80005	broad.mit.edu	37	chr8	25189802	25189802	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgttaaattggcgttccaacTcccagaacattaaacacaac	5	11	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr8:25189802T>A	uc003xeg.2	+	19	2076	c.1939T>A	c.(1939-1941)TCC>ACC	p.S647T	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.S361T|DOCK5_uc003xei.2_Missense_Mutation_p.S217T|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	647	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GCGTTCCAACTCCCAGAACAT	0.378													A	25189802	A	A	25189802	3	1	232	1	0	0	0	0	1	0	0	0	4690	1551	54	5	2013	5	DOCK5	8	25189802	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	29903	25189802	121174220	58	16432											
DOCK5	80005	broad.mit.edu	37	chr8	25265580	25265580	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccttagagaggagaacagCgagaaccggatcagcaagtt	12	9	1	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr8:25265580C>T	uc003xeg.2	+	49	5312	c.5175C>T	c.(5173-5175)AGC>AGT	p.S1725S	PPP2R2A_uc003xek.2_Intron|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1725						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		AGGAGAACAGCGAGAACCGGA	0.498													T	25265580	T	T	25265580	2	4	232	1	0	0	0	0	0	0	0	1	4690	767	27	1		1	DOCK5	8	25265580	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08	75778	25265580	121098442	59	16433											
PTK2B	2185	broad.mit.edu	37	chr8	27308400	27308400	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taccagtggctcaggcaggaGgagaagtccctggtgagcac	15	10	1	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr8:27308400G>A	uc003xfn.1	+	30	3283	c.2475G>A	c.(2473-2475)GAG>GAA	p.E825E	PTK2B_uc003xfo.1_Silent_p.E825E|PTK2B_uc003xfp.1_Silent_p.E825E|PTK2B_uc003xfq.1_Silent_p.E783E|PTK2B_uc003xfs.1_Silent_p.E22E	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	825	Interaction with TGFB1I1 (By similarity).				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TCAGGCAGGAGGAGAAGTCCC	0.607													A	27308400	A	A	27308400	2	1	232	1	0	0	0	0	0	0	0	1	12763	991	35	3		3	PTK2B	8	27308400	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	2042820	27308400	119055622	60	16434											
ADAM32	203102	broad.mit.edu	37	chr8	39111964	39111964	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagaaacaagtgccattgttCgccaggctataagcctccaa	8	12	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr8:39111964C>T	uc003xmt.3	+	18	2179	c.1934C>T	c.(1933-1935)TCG>TTG	p.S645L	ADAM32_uc011lch.1_Missense_Mutation_p.S546L|ADAM32_uc003xmu.3_Missense_Mutation_p.S539L|ADAM32_uc003xmv.2_Missense_Mutation_p.S69L	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	645	EGF-like.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TGCCATTGTTCGCCAGGCTAT	0.363													T	39111964	T	T	39111964	3	4	232	1	0	0	0	0	1	0	0	0	249	893	31	2	2004	2	ADAM32	8	39111964	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	11803564	39111964	107252058	61	16435											
JPH1	56704	broad.mit.edu	37	chr8	75227467	75227467	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tctacatcgccaaagctgatCgtggagttggcatcgctgga	12	10	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr8:75227467C>T	uc003yae.2	-	2	808	c.768G>A	c.(766-768)ACG>ACA	p.T256T	JPH1_uc003yaf.2_Silent_p.T256T|JPH1_uc003yag.1_Silent_p.T120T	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	256	Cytoplasmic (Potential).|Ser-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CAAAGCTGATCGTGGAGTTGG	0.557													T	75227467	T	T	75227467	2	4	232	1	0	0	0	0	0	0	0	1	7960	871	31	2		2	JPH1	8	75227467	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08	36115503	75227467	71136555	62	16436											
TM7SF4	81501	broad.mit.edu	37	chr8	105361318	105361318	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctctcttttcagtcccagcCatgtcctggaggcacagcta	8	14	3	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr8:105361318C>T	uc003ylx.1	+	2	587	c.538C>T	c.(538-540)CAT>TAT	p.H180Y		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	180					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CAGTCCCAGCCATGTCCTGGA	0.507													T	105361318	T	T	105361318	3	4	232	1	0	0	0	0	1	0	0	0	15973	594	21	3	540	3	TM7SF4	8	105361318	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	30133851	105361318	41002704	63	16437											
CNTNAP3	79937	broad.mit.edu	37	chr9	39176040	39176040	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacacccatgaaagcttttaCgtctgaatgcccgcgatctt	7	12	2	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr9:39176040C>T	uc004abi.2	-	7	1216	c.977G>A	c.(976-978)CGT>CAT	p.R326H	CNTNAP3_uc004abj.2_Missense_Mutation_p.R326H|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Missense_Mutation_p.R326H|CNTNAP3_uc011lqs.1_Missense_Mutation_p.R326H|CNTNAP3_uc004abl.1_Missense_Mutation_p.R238H	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	326	Extracellular (Potential).|Laminin G-like 1.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		AAAGCTTTTACGTCTGAATGC	0.388													T	39176040	T	T	39176040	3	4	232	1	0	0	0	0	1	0	0	0	3648	536	19	1	2961	1	CNTNAP3	9	39176040	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08		39176040	102037391	64	16438											
FOXD4L5	653427	broad.mit.edu	37	chr9	70177155	70177155	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcggtgccccggcatagaCgggggccgagagcagtaggt	17	11	0	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr9:70177155C>T	uc010moc.2	-	1	1661	c.829G>A	c.(829-831)GTC>ATC	p.V277I		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	277					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						CCGGCATAGACGGGGGCCGAG	0.687													T	70177155	T	T	70177155	3	4	232	1	0	0	0	0	1	0	0	0	6002	536	19	1	425	1	FOXD4L5	9	70177155	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	31001115	70177155	71036276	65	16439											
PAPPA	5069	broad.mit.edu	37	chr9	118949533	118949533	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aaagacccacgctactttttCtccttgaagacagaccgagc	7	13	1	4	rs141909455		TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr9:118949533C>G	uc004bjn.2	+	2	897	c.516C>G	c.(514-516)TTC>TTG	p.F172L	PAPPA_uc011lxp.1_5'UTR|PAPPA_uc011lxq.1_5'UTR	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	172					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GCTACTTTTTCTCCTTGAAGA	0.537													G	118949533	G	G	118949533	3	3	232	1	0	0	0	0	1	0	0	0	11432	912	32	5	522	5	PAPPA	9	118949533	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	48772378	118949533	22263898	66	16440											
NUP214	8021	broad.mit.edu	37	chr9	134016058	134016058	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctcatcaaaacaccagagCgactttcattagaaggagag	8	10	3	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr9:134016058C>T	uc004cag.2	+	11	1366	c.1255C>T	c.(1255-1257)CGA>TGA	p.R419*	NUP214_uc004cah.2_Nonsense_Mutation_p.R419*|NUP214_uc004caf.1_Nonsense_Mutation_p.R419*	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	419					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		AACACCAGAGCGACTTTCATT	0.433			T	DEK|SET|ABL1	AML|T-ALL								T	134016058	T	T	134016058	4	4	232	1	0	0	0	0	0	1	0	0	10762	760	27	1	1297	1	NUP214	9	134016058	Nonsense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	15066525	134016058	7197373	67	16441											
ANO9	338440	broad.mit.edu	37	chr11	433453	433453	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagacctgtttctggtcccGgatcacctgggggcacatgg	14	11	2	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr11:433453G>A	uc001lpi.2	-	4	296	c.211C>T	c.(211-213)CGG>TGG	p.R71W	ANO9_uc010qvv.1_5'UTR	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	71	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TTCTGGTCCCGGATCACCTGG	0.612													A	433453	A	A	433453	3	1	232	1	0	0	0	0	1	0	0	0	704	1115	39	2	2217	2	ANO9	11	433453	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08		433453	134573063	68	16442											
TTC17	55761	broad.mit.edu	37	chr11	43464880	43464880	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccttgaatttcaggtacgGtggttgaggagagcaatggt	15	6	1	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr11:43464880G>A	uc001mxi.2	+	17	2271	c.2257G>A	c.(2257-2259)GTG>ATG	p.V753M	TTC17_uc001mxh.2_Missense_Mutation_p.V810M|TTC17_uc010rfj.1_Missense_Mutation_p.V753M|TTC17_uc001mxj.2_Missense_Mutation_p.V580M	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	753							binding			ovary(5)	5						TTCAGGTACGGTGGTTGAGGA	0.308													A	43464880	A	A	43464880	3	1	232	1	0	0	0	0	1	0	0	0	16681	1261	44	3	2323	3	TTC17	11	43464880	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	43031427	43464880	91541636	69	16443											
OR4X1	390113	broad.mit.edu	37	chr11	48285739	48285739	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catttctttggtggcactgaGgcctttctcctgatggtgat	11	9	2	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr11:48285739G>A	uc010rht.1	+	1	327	c.327G>A	c.(325-327)GAG>GAA	p.E109E		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						GTGGCACTGAGGCCTTTCTCC	0.507													A	48285739	A	A	48285739	2	1	232	1	0	0	0	0	0	0	0	1	11084	991	35	3		3	OR4X1	11	48285739	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	4820859	48285739	86720777	70	16444											
ACY3	91703	broad.mit.edu	37	chr11	67413173	67413173	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggggccacctgcagatggCggcacaggtgcatggcaaag	16	12	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr11:67413173C>T	uc001omq.2	-	4	593	c.422G>A	c.(421-423)CGC>CAC	p.R141H		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	141					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	CTGCAGATGGCGGCACAGGTG	0.617													T	67413173	T	T	67413173	3	4	232	1	0	0	0	0	1	0	0	0	227	768	27	1	557	1	ACY3	11	67413173	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	19127434	67413173	67593343	71	16445											
RELT	84957	broad.mit.edu	37	chr11	73102204	73102204	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgcaggtggtttgggccttgGggggttccccgcgttccatg	17	11	0	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr11:73102204G>C	uc001otv.2	+	5	468	c.303G>C	c.(301-303)TGG>TGC	p.W101C	RELT_uc001otw.2_Missense_Mutation_p.W101C|RELT_uc009yto.1_Missense_Mutation_p.W19C|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	101	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						TTGGGCCTTGGGGGGTTCCCC	0.587													C	73102204	C	C	73102204	3	2	232	1	0	0	0	0	1	0	0	0	13221	1241	43	5	317	5	RELT	11	73102204	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	5689031	73102204	61904312	72	16446											
OR6M1	390261	broad.mit.edu	37	chr11	123676770	123676770	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aagtagaaatatgtttggatCatgcaaccagcaaaagatat	8	5	1	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr11:123676770C>T	uc010rzz.1	-	1	288	c.288G>A	c.(286-288)ATG>ATA	p.M96I		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		ATGTTTGGATCATGCAACCAG	0.458													T	123676770	T	T	123676770	3	4	232	1	0	0	0	0	1	0	0	0	11205	826	29	3	656	3	OR6M1	11	123676770	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	50574566	123676770	11329746	73	16447											
CNTN1	1272	broad.mit.edu	37	chr12	41333137	41333137	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaatttgttttctttttagCgttggctccaacttttgaaa	6	7	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr12:41333137C>T	uc001rmm.1	+	12	1342	c.1229C>T	c.(1228-1230)GCG>GTG	p.A410V	CNTN1_uc009zjy.1_Missense_Mutation_p.A410V|CNTN1_uc001rmn.1_Missense_Mutation_p.A399V|CNTN1_uc001rmo.2_Missense_Mutation_p.A410V	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	410					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTCTTTTTAGCGTTGGCTCCA	0.348													T	41333137	T	T	41333137	3	4	232	1	0	0	0	0	1	0	0	0	3640	782	27	1	1271	1	CNTN1	12	41333137	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08		41333137	92518758	74	16448											
TRHDE	29953	broad.mit.edu	37	chr12	72771778	72771778	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatatatttttaattaggtaCgattatatgcaagacctgat	6	4	0	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr12:72771778C>T	uc001sxa.2	+	3	1087	c.1057C>T	c.(1057-1059)CGA>TGA	p.R353*		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	353	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						taattaGGTACGATTATATGC	0.308													T	72771778	T	T	72771778	4	4	232	1	0	0	0	0	0	1	0	0	16476	528	19	1	1067	1	TRHDE	12	72771778	Nonsense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	31438641	72771778	61080117	75	16449											
TBX5	6910	broad.mit.edu	37	chr12	114793581	114793581	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttggccatgccagccagcCgagggaccaggggccccgag	17	14	0	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr12:114793581C>T	uc001tvo.2	-	9	1808	c.1313G>A	c.(1312-1314)CGG>CAG	p.R438Q	TBX5_uc001tvp.2_Missense_Mutation_p.R438Q|TBX5_uc001tvq.2_Missense_Mutation_p.R388Q	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	438				MDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQ TS -> WTGYPTSTSPLTSPRGPWSLGWLAWQPWLPTAGRG NVPSTRPP (in Ref. 1; CAA70592).	cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GCCAGCCAGCCGAGGGACCAG	0.657													T	114793581	T	T	114793581	3	4	232	1	0	0	0	0	1	0	0	0	15658	652	23	2	247	2	TBX5	12	114793581	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	42021803	114793581	19058314	76	16450											
FAM48A	55578	broad.mit.edu	37	chr13	37583874	37583876	+	In_Frame_Del	DEL	GAT	-	-													tgactggctgcctgtatgccGatgatgatgtagctgagctg					rs149036783		TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr13:37583874_37583876delGAT	uc001uwg.2	-	26	2521_2523	c.2273_2275delATC	c.(2272-2277)CATCGG>CGG	p.H758del	FAM48A_uc010abt.2_In_Frame_Del_p.724_725SS>S|FAM48A_uc001uwh.2_In_Frame_Del_p.724_725SS>S|FAM48A_uc001uwi.2_In_Frame_Del_p.723_724SS>S|FAM48A_uc001uwj.2_In_Frame_Del_p.724_725SS>S|FAM48A_uc001uwk.2_In_Frame_Del_p.802_803SS>S|FAM48A_uc001uwd.2_In_Frame_Del_p.210_211SS>S|FAM48A_uc001uwe.2_In_Frame_Del_p.H242del|FAM48A_uc001uwf.2_In_Frame_Del_p.H324del	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	758					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		CCTGTATGCCGATGATGATGTAG	0.424													-	37583876	-	-	37583874	7	5	232	1	0	1	0	1	0	0	0	0	5572	1059	37	0	68	0	FAM48A	13	37583874	In_Frame_Del	DEL	GAT	TCGA-32-2632-01A-01D-1495-08		37583874	77586004	77	16451											
RB1	5925	broad.mit.edu	37	chr13	48941711	48941711	+	Frame_Shift_Del	DEL	A	-	-													gattatttttggatcatgatAaaactcttcagactgattct							TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr13:48941711delA	uc001vcb.2	+	10	1187	c.1021delA	c.(1021-1023)AAAfs	p.K341fs	RB1_uc010act.1_Frame_Shift_Del_p.K42fs	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	341					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)|p.D340fs*5(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGATCATGATAAAACTCTTCA	0.279		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			-	48941711	-	-	48941711	7	5	232	1	0	1	0	1	0	0	0	0	13098	363	13	0	1059	0	RB1	13	48941711	Frame_Shift_Del	DEL	A	TCGA-32-2632-01A-01D-1495-08	11357837	48941711	66228167	78	16452											
CLYBL	171425	broad.mit.edu	37	chr13	100425234	100425234	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtagattgtgcagtgctcgaCtgtgaggatggagtggctgc	17	6	0	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr13:100425234C>G	uc001vok.2	+	2	233	c.219C>G	c.(217-219)GAC>GAG	p.D73E	CLYBL_uc010tix.1_Missense_Mutation_p.D73E|CLYBL_uc010tiy.1_Missense_Mutation_p.D73E	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	73					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAGTGCTCGACTGTGAGGATG	0.398													G	100425234	G	G	100425234	3	3	232	1	0	0	0	0	1	0	0	0	3573	564	20	5	225	5	CLYBL	13	100425234	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	51483523	100425234	14744644	79	16453											
ATP11A	23250	broad.mit.edu	37	chr13	113485796	113485796	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgccccacgtcatctgcaaCgggcaggtcctcccagagtc	11	16	2	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr13:113485796C>T	uc001vsi.3	+	13	1417	c.1329C>T	c.(1327-1329)AAC>AAT	p.N443N	ATP11A_uc001vsj.3_Silent_p.N443N|ATP11A_uc001vsm.1_Silent_p.N319N	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	443	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TCATCTGCAACGGGCAGGTCC	0.587													T	113485796	T	T	113485796	2	4	232	1	0	0	0	0	0	0	0	1	1119	535	19	1		1	ATP11A	13	113485796	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08	13060562	113485796	1684082	80	16454											
MYH7	4625	broad.mit.edu	37	chr14	23883029	23883029	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgggactcggcgatgtccGcccgctcctctgcctcatcc	10	19	2	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr14:23883029G>A	uc001wjx.2	-	39	5835	c.5729C>T	c.(5728-5730)GCG>GTG	p.A1910V		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1910	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GGCGATGTCCGCCCGCTCCTC	0.622													A	23883029	A	A	23883029	3	1	232	1	0	0	0	0	1	0	0	0	10039	1087	38	1	86	1	MYH7	14	23883029	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08		23883029	83466511	81	16455											
MYH7	4625	broad.mit.edu	37	chr14	23902877	23902877	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggtctgcgcttctagccgcTccttctctgacttgcgcagg	11	14	3	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr14:23902877T>C	uc001wjx.2	-	3	171	c.65A>G	c.(64-66)GAG>GGG	p.E22G		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	22	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTCTAGCCGCTCCTTCTCTGA	0.577													C	23902877	C	C	23902877	3	2	232	1	0	0	0	0	1	0	0	0	10039	1551	54	4	5894	4	MYH7	14	23902877	Missense_Mutation	SNP	T	TCGA-32-2632-01A-01D-1495-08	19848	23902877	83446663	82	16456											
LTBP2	4053	broad.mit.edu	37	chr14	74992813	74992813	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcatgagtgacactggtcGtgacctgcacagaaacagga	13	9	0	4			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr14:74992813G>A	uc001xqa.2	-	14	2780	c.2393C>T	c.(2392-2394)ACG>ATG	p.T798M		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	798					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GACACTGGTCGTGACCTGCAC	0.577													A	74992813	A	A	74992813	3	1	232	1	0	0	0	0	1	0	0	0	9074	1145	40	1	3164	1	LTBP2	14	74992813	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	51089936	74992813	32356727	83	16457											
NRXN3	9369	broad.mit.edu	37	chr14	79181464	79181464	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcaccggcaccggatactggGgaagaacctgcgaaaggggt	16	10	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr14:79181464G>C	uc001xun.2	+	5	1398	c.907G>C	c.(907-909)GGA>CGA	p.G303R	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.G437R	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	676	EGF-like 2.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CGGATACTGGGGAAGAACCTG	0.587													C	79181464	C	C	79181464	3	2	232	1	0	0	0	0	1	0	0	0	10667	1233	43	5	917	5	NRXN3	14	79181464	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	4188651	79181464	28168076	84	16458											
TDRD9	122402	broad.mit.edu	37	chr14	104481128	104481128	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acatgcatgttgattctcggCgacctgtcatggaccaagag	11	10	2	2	rs143367834		TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr14:104481128C>T	uc001yom.3	+	21	2203	c.2173C>T	c.(2173-2175)CGA>TGA	p.R725*	TDRD9_uc001yon.3_Nonsense_Mutation_p.R463*	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	725					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				TGATTCTCGGCGACCTGTCAT	0.368													T	104481128	T	T	104481128	4	4	232	1	0	0	0	0	0	1	0	0	15733	760	27	1	2255	1	TDRD9	14	104481128	Nonsense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	25299664	104481128	2868412	85	16459											
NDN	4692	broad.mit.edu	37	chr15	23931758	23931758	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgctctctctggcgccgcGgcccttcacgtagatgaggc	14	15	3	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr15:23931758G>A	uc001ywk.2	-	1	693	c.607C>T	c.(607-609)CGC>TGC	p.R203C		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	203	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CTGGCGCCGCGGCCCTTCACG	0.662									Prader-Willi_syndrome				A	23931758	A	A	23931758	3	1	232	1	0	0	0	0	1	0	0	0	10247	1116	39	2	362	2	NDN	15	23931758	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08		23931758	78599634	86	16460											
CSPG4	1464	broad.mit.edu	37	chr15	75980642	75980642	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gttgagactcttgacaaagaGgtggtcagcagagaggacac	14	7	2	4			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr15:75980642G>T	uc002baw.2	-	3	2857	c.2764C>A	c.(2764-2766)CTC>ATC	p.L922I		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	922	Interaction with COL5A1 (By similarity).|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|CSPG 5.|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						TTGACAAAGAGGTGGTCAGCA	0.597													T	75980642	T	T	75980642	3	4	232	1	0	0	0	0	1	0	0	0	3960	1000	35	5	4236	5	CSPG4	15	75980642	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	52048884	75980642	26550750	87	16461											
SYNM	23336	broad.mit.edu	37	chr15	99669677	99669677	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttggcaagtttcaatcacaGctcggcactgtattctaacc	7	11	3	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr15:99669677G>A	uc002bup.2	+	6	1232	c.1112G>A	c.(1111-1113)AGC>AAC	p.S371N	SYNM_uc002buo.2_Missense_Mutation_p.S371N|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	371	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						TTCAATCACAGCTCGGCACTG	0.463													A	99669677	A	A	99669677	3	1	232	1	0	0	0	0	1	0	0	0	15452	971	34	3	1125	3	SYNM	15	99669677	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	23689035	99669677	2861715	88	16462											
GRIN2A	2903	broad.mit.edu	37	chr16	9943739	9943739	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgagatggttgtcatccGgctcacagtcggagaaggac	14	9	2	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr16:9943739G>A	uc002czo.3	-	5	1750	c.1202C>T	c.(1201-1203)CCG>CTG	p.P401L	GRIN2A_uc010uym.1_Missense_Mutation_p.P401L|GRIN2A_uc010uyn.1_Missense_Mutation_p.P244L|GRIN2A_uc002czr.3_Missense_Mutation_p.P401L	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	401	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTTGTCATCCGGCTCACAGTC	0.587													A	9943739	A	A	9943739	3	1	232	1	0	0	0	0	1	0	0	0	6779	1116	39	2	3228	2	GRIN2A	16	9943739	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08		9943739	80411014	89	16463											
HYDIN	54768	broad.mit.edu	37	chr16	70866858	70866858	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaaaggctctcctttcccaCctcggtgggatggtaggtca	11	12	2	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr16:70866858C>T	uc002ezr.2	-	80	13917	c.13789G>A	c.(13789-13791)GTG>ATG	p.V4597M	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4598										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TCCTTTCCCACCTCGGTGGGA	0.493													T	70866858	T	T	70866858	3	4	232	1	0	0	0	0	1	0	0	0	7467	507	18	3	1601	3	HYDIN	16	70866858	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	60923119	70866858	19487895	90	16464											
PRDM7	11105	broad.mit.edu	37	chr16	90128375	90128375	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctcttcgtcttctgtaattCggccctcataggggccaaag	9	13	4	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr16:90128375C>T	uc010cje.2	-	7	856	c.836G>A	c.(835-837)CGA>CAA	p.R279Q	PRDM7_uc002fqo.2_Missense_Mutation_p.R73Q|PRDM7_uc010cjf.2_Missense_Mutation_p.R162Q|PRDM7_uc010cjg.1_Missense_Mutation_p.R73Q|PRDM7_uc010cjh.1_RNA	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	279	SET.					chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TTCTGTAATTCGGCCCTCATA	0.547													T	90128375	T	T	90128375	3	4	232	1	0	0	0	0	1	0	0	0	12461	884	31	2	658	2	PRDM7	16	90128375	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	19261517	90128375	226378	91	16465											
MYOCD	93649	broad.mit.edu	37	chr17	12626268	12626268	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctctacgaccagggccactgGagctggtggaaaaaaacatt	11	10	1	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr17:12626268G>A	uc002gnn.2	+	5	657	c.358G>A	c.(358-360)GAG>AAG	p.E120K	MYOCD_uc002gno.2_Missense_Mutation_p.E120K|MYOCD_uc002gnp.1_Missense_Mutation_p.E24K	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	120	RPEL 3.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGGGCCACTGGAGCTGGTGGA	0.468													A	12626268	A	A	12626268	3	1	232	1	0	0	0	0	1	0	0	0	10087	1175	41	3	376	3	MYOCD	17	12626268	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08		12626268	68568942	92	16466											
CCL14	6358	broad.mit.edu	37	chr17	34311432	34311432	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtaatccataatccgctgacGcgggatcttgtaggtagtgt	12	8	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr17:34311432G>A	uc010wcr.1	-	2	215	c.136C>T	c.(136-138)CGT>TGT	p.R46C	CCL16_uc002hkl.2_5'Flank|CCL16_uc002hkm.2_5'Flank|CCL14_uc010wcq.1_Missense_Mutation_p.R62C|CCL14_uc002hkn.2_RNA|CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA|uc002hkq.2_5'Flank	NM_032963	NP_116739	Q16627	CCL14_HUMAN	chemokine (C-C motif) ligand 14 isoform 1	46					cellular calcium ion homeostasis|immune response|positive regulation of cell proliferation	extracellular space	chemokine activity|signal transducer activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ATCCGCTGACGCGGGATCTTG	0.552													A	34311432	A	A	34311432	3	1	232	1	0	0	0	0	1	0	0	0	2885	1087	38	1	153	1	CCL14	17	34311432	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	21685164	34311432	46883778	93	16467											
KRT38	8687	broad.mit.edu	37	chr17	39597030	39597030	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actcggttggcatgtgccacGttggccaaaaggcacatggg	14	10	0	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr17:39597030G>A	uc002hwq.1	-	1	567	c.144C>T	c.(142-144)AAC>AAT	p.N48N		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	48	Head.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				CATGTGCCACGTTGGCCAAAA	0.632													A	39597030	A	A	39597030	2	1	232	1	0	0	0	0	0	0	0	1	8475	1136	40	1		1	KRT38	17	39597030	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	5285598	39597030	41598180	94	16468											
ABCA9	10350	broad.mit.edu	37	chr17	67041451	67041451	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	caattcatccatgcttttttCatcaggccaccccatgattg	5	13	3	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr17:67041451C>T	uc002jhu.2	-	4	474	c.331G>A	c.(331-333)GAA>AAA	p.E111K	ABCA9_uc010dez.2_Missense_Mutation_p.E111K|ABCA9_uc002jhv.2_Missense_Mutation_p.E111K	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	111					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					ATGCTTTTTTCATCAGGCCAC	0.383													T	67041451	T	T	67041451	3	4	232	1	0	0	0	0	1	0	0	0	39	835	29	3	4687	3	ABCA9	17	67041451	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	27444421	67041451	14153759	95	16469											
CABYR	26256	broad.mit.edu	37	chr18	21735681	21735681	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcagtagagaaatggtcagaAggaacgacaccacagaagaa	11	7	2	4			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr18:21735681A>T	uc002kux.2	+	4	368	c.216A>T	c.(214-216)GAA>GAT	p.E72D	CABYR_uc010xbb.1_Translation_Start_Site|CABYR_uc002kuy.2_Missense_Mutation_p.E72D|CABYR_uc002kuz.2_Missense_Mutation_p.E72D|CABYR_uc002kva.2_Missense_Mutation_p.E54D|CABYR_uc002kvb.2_Translation_Start_Site|CABYR_uc002kvc.2_Missense_Mutation_p.E72D|CABYR_uc010dlw.2_RNA	NM_012189	NP_036321	O75952	CABYR_HUMAN	calcium-binding tyrosine	72					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding				0	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					AATGGTCAGAAGGAACGACAC	0.323													T	21735681	T	T	21735681	3	4	232	1	0	0	0	0	1	0	0	0	2536	69	3	5	226	5	CABYR	18	21735681	Missense_Mutation	SNP	A	TCGA-32-2632-01A-01D-1495-08		21735681	56341567	96	16470											
MEP1B	4225	broad.mit.edu	37	chr18	29784271	29784271	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggattctggcatgagcagtcGcgttctgaccgggatgacta	14	9	2	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr18:29784271G>A	uc002kxj.3	+	7	542	c.495G>A	c.(493-495)TCG>TCA	p.S165S		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	165	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						ATGAGCAGTCGCGTTCTGACC	0.458													A	29784271	A	A	29784271	2	1	232	1	0	0	0	0	0	0	0	1	9476	1074	38	1		1	MEP1B	18	29784271	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	8048590	29784271	48292977	97	16471											
TNFRSF11A	8792	broad.mit.edu	37	chr18	60017106	60017106	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatgtctgccctgtggcccGgatgaatacttggatagctg	13	9	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr18:60017106G>A	uc002lin.2	+	3	257	c.219G>A	c.(217-219)CCG>CCA	p.P73P	TNFRSF11A_uc010dpv.2_Silent_p.P73P	NM_003839	NP_003830	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily,	73	TNFR-Cys 2.|Extracellular (Potential).				adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(2)|lung(1)	3		Colorectal(73;0.188)				CCTGTGGCCCGGATGAATACT	0.418									Paget_Disease_of_Bone				A	60017106	A	A	60017106	2	1	232	1	0	0	0	0	0	0	0	1	16281	1103	39	2		2	TNFRSF11A	18	60017106	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	30232835	60017106	18060142	98	16472											
HMHA1	23526	broad.mit.edu	37	chr19	1080969	1080969	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccacgaggggctgtccaaggCggcccgtactcaccggctcc	13	17	1	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr19:1080969C>T	uc002lqz.1	+	17	2327	c.2096C>T	c.(2095-2097)GCG>GTG	p.A699V	HMHA1_uc010xgd.1_Missense_Mutation_p.A715V|HMHA1_uc010xge.1_Missense_Mutation_p.A567V|HMHA1_uc002lra.1_Missense_Mutation_p.A539V|HMHA1_uc002lrb.1_Missense_Mutation_p.A582V|HMHA1_uc002lrc.1_Missense_Mutation_p.A334V|HMHA1_uc002lrd.1_5'Flank|HMHA1_uc010dsd.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	699					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGTCCAAGGCGGCCCGTACT	0.682													T	1080969	T	T	1080969	3	4	232	1	0	0	0	0	1	0	0	0	7240	768	27	1	2162	1	HMHA1	19	1080969	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08		1080969	58048014	99	16473											
RDH8	50700	broad.mit.edu	37	chr19	10131987	10131987	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgaggggaagcttctggCgcaggtttctatggctgagt	16	6	2	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr19:10131987C>T	uc002mmr.2	+	5	842	c.593C>T	c.(592-594)GCG>GTG	p.A198V		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	198					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	AAGCTTCTGGCGCAGGTTTCT	0.602													T	10131987	T	T	10131987	3	4	232	1	0	0	0	0	1	0	0	0	13196	768	27	1	611	1	RDH8	19	10131987	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	9051018	10131987	48996996	100	16474											
CYP4F22	126410	broad.mit.edu	37	chr19	15651449	15651449	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaacggcggcgggcactgcGtcagcagggggccgaggcct	20	12	1	0	rs146265982		TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr19:15651449G>A	uc002nbh.3	+	8	1027	c.860G>A	c.(859-861)CGT>CAT	p.R287H		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	287						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						CGGGCACTGCGTCAGCAGGGG	0.632													A	15651449	A	A	15651449	3	1	232	1	0	0	0	0	1	0	0	0	4189	1145	40	1	882	1	CYP4F22	19	15651449	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	5519462	15651449	43477534	101	16475											
GTPBP3	84705	broad.mit.edu	37	chr19	17452117	17452117	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctggaggcgctgaggaaGgagctagctgcagtgtgagc	17	9	0	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr19:17452117G>A	uc010eas.2	+	8	1304	c.1239G>A	c.(1237-1239)AAG>AAA	p.K413K	GTPBP3_uc010xpo.1_Silent_p.K435K|GTPBP3_uc002ngh.3_Silent_p.K392K|GTPBP3_uc002ngg.3_Silent_p.K445K|GTPBP3_uc002ngi.3_Silent_p.K79K	NM_032620	NP_116009	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial) isoform V	413					tRNA modification	mitochondrion	GTP binding|GTPase activity			skin(1)	1						CGCTGAGGAAGGAGCTAGCTG	0.572													A	17452117	A	A	17452117	2	1	232	1	0	0	0	0	0	0	0	1	6881	991	35	3		3	GTPBP3	19	17452117	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08	1800668	17452117	41676866	102	16476											
PGPEP1	54858	broad.mit.edu	37	chr19	18468321	18468321	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccagtgctgcgtggaggaCgggcctgaaagcattgactc	14	11	0	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr19:18468321C>T	uc002nis.1	+	4	417	c.333C>T	c.(331-333)GAC>GAT	p.D111D	PGPEP1_uc002nir.1_RNA|PGPEP1_uc002nit.1_Silent_p.D34D|PGPEP1_uc010xqg.1_Silent_p.D34D	NM_017712	NP_060182	Q9NXJ5	PGPI_HUMAN	pyroglutamyl-peptidase I	111							cysteine-type peptidase activity				0						GCGTGGAGGACGGGCCTGAAA	0.592													T	18468321	T	T	18468321	2	4	232	1	0	0	0	0	0	0	0	1	11803	535	19	1		1	PGPEP1	19	18468321	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08	1016204	18468321	40660662	103	16477											
ZNF599	148103	broad.mit.edu	37	chr19	35250777	35250777	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cacattctttgcataaaaagGgtttttctcgagtgtgagtc	9	7	2	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr19:35250777G>T	uc010edn.1	-	4	1317	c.929C>A	c.(928-930)CCC>CAC	p.P310H	ZNF599_uc010edm.1_Missense_Mutation_p.P273H	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GCATAAAAAGGGTTTTTCTCG	0.418													T	35250777	T	T	35250777	3	4	232	1	0	0	0	0	1	0	0	0	18026	1232	43	5	841	5	ZNF599	19	35250777	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	16782456	35250777	23878206	104	16478											
CCDC8	83987	broad.mit.edu	37	chr19	46914658	46914658	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcttgacctgtttccgggcCctggctcctggagctgttcc	12	14	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr19:46914658C>T	uc002pep.2	-	1	2262	c.1410G>A	c.(1408-1410)AGG>AGA	p.R470R		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	470						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		GTTTCCGGGCCCTGGCTCCTG	0.612													T	46914658	T	T	46914658	2	4	232	1	0	0	0	0	0	0	0	1	2853	622	22	3		3	CCDC8	19	46914658	Silent	SNP	C	TCGA-32-2632-01A-01D-1495-08	11663881	46914658	12214325	105	16479											
LILRB1	10859	broad.mit.edu	37	chr19	55147969	55147969	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcccacacgatgaagaccccCaggcagtgacgtatgccgag	12	14	0	3			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr19:55147969C>A	uc002qgj.2	+	15	2012	c.1672C>A	c.(1672-1674)CAG>AAG	p.Q558K	LILRB1_uc010erp.1_3'UTR|LILRB1_uc002qgl.2_Missense_Mutation_p.Q559K|LILRB1_uc002qgk.2_Missense_Mutation_p.Q559K|LILRB1_uc002qgm.2_Missense_Mutation_p.Q560K|LILRB1_uc010erq.2_Missense_Mutation_p.Q542K|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	558	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		TGAAGACCCCCAGGCAGTGAC	0.572										HNSCC(37;0.09)			A	55147969	A	A	55147969	3	1	232	1	0	0	0	0	1	0	0	0	8790	595	21	5	1728	5	LILRB1	19	55147969	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	8233311	55147969	3981014	106	16480											
NLRP7	199713	broad.mit.edu	37	chr19	55451000	55451000	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaccggctgcagaggaaaCgcaggaacagccccgtgcgg	16	12	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr19:55451000C>T	uc002qih.3	-	4	1263	c.1187G>A	c.(1186-1188)CGT>CAT	p.R396H	NLRP7_uc002qig.3_Missense_Mutation_p.R396H|NLRP7_uc002qii.3_Missense_Mutation_p.R396H|NLRP7_uc010esk.2_Missense_Mutation_p.R396H|NLRP7_uc010esl.2_Missense_Mutation_p.R424H	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	396	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GCAGAGGAAACGCAGGAACAG	0.706													T	55451000	T	T	55451000	3	4	232	1	0	0	0	0	1	0	0	0	10482	536	19	1	1958	1	NLRP7	19	55451000	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	303031	55451000	3677983	107	16481											
PHF20	51230	broad.mit.edu	37	chr20	34526877	34526877	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tattaccctgccgtggagcaGaagctggtggtggagacgag	16	8	0	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr20:34526877G>A	uc002xek.1	+	16	2670	c.2559G>A	c.(2557-2559)CAG>CAA	p.Q853Q		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	853					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CCGTGGAGCAGAAGCTGGTGG	0.647													A	34526877	A	A	34526877	2	1	232	1	0	0	0	0	0	0	0	1	11831	933	33	3		3	PHF20	20	34526877	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08		34526877	28498643	108	16482											
SEMG1	6406	broad.mit.edu	37	chr20	43836560	43836560	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagtagctaacaaacaacaaCgtgagactaaaaattctcat	5	8	1	1	rs141417035	by1000genomes	TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr20:43836560C>T	uc002xni.2	+	2	679	c.622C>T	c.(622-624)CGT>TGT	p.R208C	SEMG1_uc002xnj.2_Missense_Mutation_p.R208C|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.R208C	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	208	42 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				CAAACAACAACGTGAGACTAA	0.403													T	43836560	T	T	43836560	3	4	232	1	0	0	0	0	1	0	0	0	14044	536	19	1	628	1	SEMG1	20	43836560	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	9309683	43836560	19188960	109	16483											
ADAMTS1	9510	broad.mit.edu	37	chr21	28217207	28217207	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctccgagaccccggagcccGctccgcgttccccatgtcgc	11	20	0	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr21:28217207G>T	uc002ymf.2	-	1	522	c.67C>A	c.(67-69)CGG>AGG	p.R23R		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	23					integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		CCCGGAGCCCGCTCCGCGTTC	0.711											OREG0026151	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	28217207	T	T	28217207	2	4	232	1	0	0	0	0	0	0	0	1	255	1086	38	5		5	ADAMTS1	21	28217207	Silent	SNP	G	TCGA-32-2632-01A-01D-1495-08		28217207	19912688	110	16484											
RNF160	26046	broad.mit.edu	37	chr21	30359239	30359239	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggcaaggagttctgcagctCggccactgtttgaaggctga	14	9	1	2			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr21:30359239C>T	uc002ymr.2	-	2	210	c.197G>A	c.(196-198)CGA>CAA	p.R66Q	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	20							ligase activity|zinc ion binding				0						TTCTGCAGCTCGGCCACTGTT	0.433													T	30359239	T	T	30359239	3	4	232	1	0	0	0	0	1	0	0	0	13455	884	31	2	5357	2	RNF160	21	30359239	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	2142032	30359239	17770656	111	16485											
NHP2L1	4809	broad.mit.edu	37	chr22	42071074	42071074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccagggcctgcttggagcGcacaaacacgtagggcacat	12	14	0	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr22:42071074G>A	uc003bat.2	-	3	444	c.250C>T	c.(250-252)CGC>TGC	p.R84C	NHP2L1_uc003bau.2_Missense_Mutation_p.R84C|NHP2L1_uc003bav.2_Missense_Mutation_p.R84C|NHP2L1_uc003baw.2_Missense_Mutation_p.R84C	NM_005008	NP_004999	P55769	NH2L1_HUMAN	NHP2 non-histone chromosome protein 2-like 1	84					nuclear mRNA splicing, via spliceosome|ribosome biogenesis	box C/D snoRNP complex|nucleoplasm|spliceosomal complex	protein binding|RNA binding				0						TGCTTGGAGCGCACAAACACG	0.577													A	42071074	A	A	42071074	3	1	232	1	0	0	0	0	1	0	0	0	10410	1087	38	1	140	1	NHP2L1	22	42071074	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08		42071074	9233492	112	16486											
EFCAB6	64800	broad.mit.edu	37	chr22	43933388	43933388	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggatcacagttctgcaagGgtggagtgcccgggatcacg	16	9	3	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chr22:43933388G>A	uc003bdy.1	-	29	4132	c.3917C>T	c.(3916-3918)CCC>CTC	p.P1306L	EFCAB6_uc003bdz.1_Missense_Mutation_p.P1154L|EFCAB6_uc010gzi.1_Missense_Mutation_p.P1154L	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1306	Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				GTTCTGCAAGGGTGGAGTGCC	0.517													A	43933388	A	A	43933388	3	1	232	1	0	0	0	0	1	0	0	0	4939	1232	43	3	604	3	EFCAB6	22	43933388	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	1862314	43933388	7371178	113	16487											
DMD	1756	broad.mit.edu	37	chrX	32486813	32486813	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccactttgttgctcttgcagAgaactttgtaaagcctaaaa	7	9	1	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chrX:32486813A>G	uc004dda.1	-	23	3208	c.2964T>C	c.(2962-2964)TCT>TCC	p.S988S	DMD_uc004dcz.2_Silent_p.S865S|DMD_uc004dcy.1_Silent_p.S984S|DMD_uc004ddb.1_Silent_p.S980S|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	988	Spectrin 6.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GCTCTTGCAGAGAACTTTGTA	0.333													G	32486813	G	G	32486813	2	3	232	1	0	0	0	0	0	0	0	1	4580	291	11	4		4	DMD	23	32486813	Silent	SNP	A	TCGA-32-2632-01A-01D-1495-08		32486813	122783747	114	16488											
RPGR	6103	broad.mit.edu	37	chrX	38182768	38182768	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttttcccaaatgtaaacacaGcacccgaatctgcaaatata	4	11	1	0			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chrX:38182768G>A	uc004ded.1	-	2	206	c.38C>T	c.(37-39)GCT>GTT	p.A13V	RPGR_uc004deb.2_Missense_Mutation_p.A13V|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	13					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TGTAAACACAGCACCCGAATC	0.318													A	38182768	A	A	38182768	3	1	232	1	0	0	0	0	1	0	0	0	13548	971	34	3	4035	3	RPGR	23	38182768	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	5695955	38182768	117087792	115	16489											
BHLHB9	80823	broad.mit.edu	37	chrX	102004542	102004543	+	Frame_Shift_Ins	INS	-	A	A													gcctgtgtatgaaattaatgINSaaaaaaataggcccaaggac							TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chrX:102004542_102004543insA	uc010nog.2	+	4	1190_1191	c.619_620insA	c.(619-621)GAAfs	p.E207fs	BHLHB9_uc011mrq.1_Frame_Shift_Ins_p.E207fs|BHLHB9_uc011mrr.1_Frame_Shift_Ins_p.E207fs|BHLHB9_uc011mrs.1_Frame_Shift_Ins_p.E207fs|BHLHB9_uc011mrt.1_Frame_Shift_Ins_p.E207fs|BHLHB9_uc004ejo.2_Frame_Shift_Ins_p.E207fs|BHLHB9_uc011mru.1_Frame_Shift_Ins_p.E207fs|BHLHB9_uc011mrv.1_Frame_Shift_Ins_p.E207fs	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	207						cytoplasm|nucleus	binding			ovary(2)	2						TGAAATTAATGAAAAAAATAGG	0.45													A	102004543	A	A	102004542	7	5	232	1	0	1	1	0	0	0	0	0	1420	1291	45	0	621	0	BHLHB9	23	102004542	Frame_Shift_Ins	INS	-	TCGA-32-2632-01A-01D-1495-08	63821774	102004542	53266018	116	16490											
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011591	105011591	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaagatacccaggaatttcaCaggaacagttctttgctgcc	8	10	2	1			TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chrX:105011591C>A	uc004elz.1	+	11	2754	c.1998C>A	c.(1996-1998)CAC>CAA	p.H666Q		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	666	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						AGGAATTTCACAGGAACAGTT	0.428													A	105011591	A	A	105011591	3	1	232	1	0	0	0	0	1	0	0	0	7662	477	17	5	2036	5	IL1RAPL2	23	105011591	Missense_Mutation	SNP	C	TCGA-32-2632-01A-01D-1495-08	3007049	105011591	50258969	117	16491											
COL4A5	1287	broad.mit.edu	37	chrX	107841977	107841977	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggtccccctgggaacccaGgtttaccaggcctcccaggg	13	15	0	0	rs104886135		TCGA-32-2632-01A-01D-1495-08	TCGA-32-2632-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	27203e18-af27-478c-a224-8bca77a81c90	9066c898-8b09-4549-b148-645610211e47	g.chrX:107841977G>A	uc004enz.1	+	25	2027	c.1825G>A	c.(1825-1827)GGT>AGT	p.G609S	COL4A5_uc011mso.1_Missense_Mutation_p.G609S|COL4A5_uc004eob.1_Missense_Mutation_p.G217S	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	609	Triple-helical region.		G -> V (in APSX; juvenile type).|G -> R (in APSX; juvenile type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						TGGGAACCCAGGTTTACCAGG	0.483									Alport_syndrome_with_Diffuse_Leiomyomatosis				A	107841977	A	A	107841977	3	1	232	1	0	0	0	0	1	0	0	0	3694	1000	35	3	1923	3	COL4A5	23	107841977	Missense_Mutation	SNP	G	TCGA-32-2632-01A-01D-1495-08	2830386	107841977	47428583	118	16492											
KDM1A	23028	broad.mit.edu	37	chr1	23381588	23381589	+	Frame_Shift_Del	DEL	CA	-	-													ctgtgcttgtccaccgagttCacagttatttagagcgtcat							TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr1:23381588_23381589delCA	uc001bgi.2	+	5	906_907	c.757_758delCA	c.(757-759)CACfs	p.H253fs	KDM1A_uc001bgj.2_Frame_Shift_Del_p.H273fs	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	253	SWIRM.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						CCACCGAGTTCACAGTTATTTA	0.371													-	23381589	-	-	23381588	7	5	233	1	0	1	0	1	0	0	0	0	8122	826	29	0	839	0	KDM1A	1	23381588	Frame_Shift_Del	DEL	CA	TCGA-32-2634-01A-01D-1495-08		23381588	225869033	1	16493											
TARS2	80222	broad.mit.edu	37	chr1	150471051	150471051	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgactttggggctctacacCgggccgaagcctctggtggt	14	12	2	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr1:150471051C>T	uc001euq.2	+	11	1319	c.1312C>T	c.(1312-1314)CGG>TGG	p.R438W	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.R356W|TARS2_uc009wlt.2_Missense_Mutation_p.R64W|TARS2_uc009wls.2_Missense_Mutation_p.R308W	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	438					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	GGCTCTACACCGGGCCGAAGC	0.632													T	150471051	T	T	150471051	3	4	233	1	0	0	0	0	1	0	0	0	15557	643	23	2	1354	2	TARS2	1	150471051	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	127089463	150471051	98779570	2	16494											
TRIM11	81559	broad.mit.edu	37	chr1	228582635	228582635	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcccggagtggagccaagGcccgttccgaggaattgtaa	15	10	0	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr1:228582635G>A	uc001hss.2	-	6	1433	c.1178C>T	c.(1177-1179)GCC>GTC	p.A393V	TRIM11_uc010pvx.1_Missense_Mutation_p.A392V	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	393	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			lung(3)|ovary(1)	4		Prostate(94;0.0724)				TGGAGCCAAGGCCCGTTCCGA	0.597													A	228582635	A	A	228582635	3	1	233	1	0	0	0	0	1	0	0	0	16484	1203	42	3	232	3	TRIM11	1	228582635	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08	78111584	228582635	20667986	3	16495											
COG2	22796	broad.mit.edu	37	chr1	230820980	230820980	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gatactctgtgtttgtcaatGaggtaagggctggctgtgga	15	5	2	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr1:230820980G>C	uc001htw.2	+	12	1529	c.1378G>C	c.(1378-1380)GAG>CAG	p.E460Q	COG2_uc001htx.2_Missense_Mutation_p.E460Q|COG2_uc010pwc.1_Missense_Mutation_p.E333Q	NM_007357	NP_031383	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2 isoform	460					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GTTTGTCAATGAGGTAAGGGC	0.423													C	230820980	C	C	230820980	3	2	233	1	0	0	0	0	1	0	0	0	3658	1291	45	5	1424	5	COG2	1	230820980	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08	2238345	230820980	18429641	4	16496											
THSD7B	80731	broad.mit.edu	37	chr2	137814764	137814764	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttatcaaacccggcaggtttCgtgtacaagaagtgatggac	11	8	1	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr2:137814764C>T	uc002tva.1	+	2	821	c.821C>T	c.(820-822)TCG>TTG	p.S274L	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.S164L	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CGGCAGGTTTCGTGTACAAGA	0.363													T	137814764	T	T	137814764	3	4	233	1	0	0	0	0	1	0	0	0	15877	893	31	2	827	2	THSD7B	2	137814764	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08		137814764	105384609	5	16497											
OBFC2A	64859	broad.mit.edu	37	chr2	192546717	192546717	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgacactttatactggaagGggtggtgaacttcaaaaaat	10	6	1	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr2:192546717G>A	uc002usx.2	+	3	756	c.276G>A	c.(274-276)AGG>AGA	p.R92R	OBFC2A_uc002usw.2_Silent_p.R12R|OBFC2A_uc002usy.2_RNA|OBFC2A_uc002usz.2_RNA|OBFC2A_uc002uta.2_Silent_p.R12R	NM_001031716	NP_001026886	Q96AH0	SOSB2_HUMAN	oligonucleotide/oligosaccharide-binding fold	92	OB.				double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	single-stranded DNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.061)|Epithelial(96;0.244)			ATACTGGAAGGGGTGGTGAAC	0.289													A	192546717	A	A	192546717	2	1	233	1	0	0	0	0	0	0	0	1	10808	1223	43	3		3	OBFC2A	2	192546717	Silent	SNP	G	TCGA-32-2634-01A-01D-1495-08	54731953	192546717	50652656	6	16498											
RPE	6120	broad.mit.edu	37	chr2	210881273	210881273	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacctcagttgagtatttgGcaccatgggctaatcagata	10	8	2	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr2:210881273G>A	uc002vdn.2	+	4	390	c.385G>A	c.(385-387)GCA>ACA	p.A129T	RPE_uc002vdm.2_Missense_Mutation_p.A129T|RPE_uc002vdo.2_Missense_Mutation_p.A79T|RPE_uc010zjf.1_Missense_Mutation_p.A129T|RPE_uc002vdp.2_Missense_Mutation_p.A76T|RPE_uc010fup.2_Missense_Mutation_p.A61T|RPE_uc002vdq.2_Missense_Mutation_p.A79T|RPE_uc002vdr.2_Intron	NM_199229	NP_954699	Q96AT9	RPE_HUMAN	ribulose-5-phosphate-3-epimerase isoform 1	129					pentose-phosphate shunt	cytosol	metal ion binding|protein homodimerization activity|ribulose-phosphate 3-epimerase activity				0				Epithelial(149;0.00241)|Lung(261;0.041)|all cancers(144;0.0429)|LUSC - Lung squamous cell carcinoma(261;0.0431)		TGAGTATTTGGCACCATGGGC	0.398													A	210881273	A	A	210881273	3	1	233	1	0	0	0	0	1	0	0	0	13544	1203	42	3	457	3	RPE	2	210881273	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08	18334556	210881273	32318100	7	16499											
NISCH	11188	broad.mit.edu	37	chr3	52521429	52521440	+	In_Frame_Del	DEL	GAGGAGGAGGAA	-	-													aacagggcgaggaggaggatGaggaggaggaagaagaggag							TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr3:52521429_52521440delGAGGAGGAGGAA	uc011beg.1	+	17	1993_2004	c.1921_1932delGAGGAGGAGGAA	c.(1921-1932)GAGGAGGAGGAAdel	p.EEEE641del	NISCH_uc003ded.3_In_Frame_Del_p.EEEE641del|NISCH_uc003dee.3_In_Frame_Del_p.EEEE130del|NISCH_uc003deg.1_RNA	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	641_644	Necessary for homooligomerization and targeting to endosomes.|Potential.|Glu-rich.|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		ggaggaggatgaggaggaggaagaagaggagg	0.406													-	52521440	-	-	52521429	7	5	233	1	0	1	0	1	0	0	0	0	10432	1291	45	0	1983	0	NISCH	3	52521429	In_Frame_Del	DEL	GAGGAGGAGGAA	TCGA-32-2634-01A-01D-1495-08		52521429	145501001	8	16500											
MAN2B2	23324	broad.mit.edu	37	chr4	6598876	6598876	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacgggcttctacacgtcccGcagctcactgaaggggctgg	14	13	2	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr4:6598876G>A	uc003gjf.1	+	8	1130	c.1094G>A	c.(1093-1095)CGC>CAC	p.R365H	MAN2B2_uc003gje.1_Missense_Mutation_p.R365H|MAN2B2_uc011bwf.1_Missense_Mutation_p.R314H	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	365					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						TACACGTCCCGCAGCTCACTG	0.632													A	6598876	A	A	6598876	3	1	233	1	0	0	0	0	1	0	0	0	9217	1087	38	1	1124	1	MAN2B2	4	6598876	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08		6598876	184555400	9	16501											
KIT	3815	broad.mit.edu	37	chr4	55561826	55561826	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggacttttgagatcctggaTgaaacgaatgagaataagca	11	5	0	3			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr4:55561826T>A	uc010igr.2	+	2	303	c.216T>A	c.(214-216)GAT>GAA	p.D72E	KIT_uc010igs.2_Missense_Mutation_p.D72E	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	72	Extracellular (Potential).|Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.571_572>GE(1)		soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGATCCTGGATGAAACGAATG	0.463		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				A	55561826	A	A	55561826	3	1	233	1	0	0	0	0	1	0	0	0	8329	1461	51	5	222	5	KIT	4	55561826	Missense_Mutation	SNP	T	TCGA-32-2634-01A-01D-1495-08	48962950	55561826	135592450	10	16502											
BANK1	55024	broad.mit.edu	37	chr4	102816534	102816534	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taccatattatgagttccagTctcttcaaactgaaatttgt	5	8	2	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr4:102816534T>C	uc003hvy.3	+	6	1250	c.976T>C	c.(976-978)TCT>CCT	p.S326P	BANK1_uc003hvx.3_Missense_Mutation_p.S311P|BANK1_uc010ill.2_Missense_Mutation_p.S193P|BANK1_uc003hvz.3_Missense_Mutation_p.S296P	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	326	DBB.				B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TGAGTTCCAGTCTCTTCAAAC	0.303													C	102816534	C	C	102816534	3	2	233	1	0	0	0	0	1	0	0	0	1309	1667	58	4	998	4	BANK1	4	102816534	Missense_Mutation	SNP	T	TCGA-32-2634-01A-01D-1495-08	47254708	102816534	88337742	11	16503											
OTUD4	54726	broad.mit.edu	37	chr4	146059760	146059760	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggtaggcctggtgcagagGgtacaggtaagaatgtgggg	19	5	0	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr4:146059760G>A	uc003ika.3	-	21	2110	c.1972C>T	c.(1972-1974)CCT>TCT	p.P658S	OTUD4_uc003ijz.3_Missense_Mutation_p.P657S	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	722							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					TGGTGCAGAGGGTACAGGTAA	0.488													A	146059760	A	A	146059760	3	1	233	1	0	0	0	0	1	0	0	0	11314	1232	43	3	1181	3	OTUD4	4	146059760	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08	43243226	146059760	45094516	12	16504											
DNAH5	1767	broad.mit.edu	37	chr5	13841119	13841119	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgtggtgacgtctatcaatgTattgagtagctccaggaaag	12	7	2	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr5:13841119T>C	uc003jfd.2	-	34	5647	c.5605A>G	c.(5605-5607)ACA>GCA	p.T1869A		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1869	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTATCAATGTATTGAGTAGC	0.413									Kartagener_syndrome				C	13841119	C	C	13841119	3	2	233	1	0	0	0	0	1	0	0	0	4604	1638	57	4	8453	4	DNAH5	5	13841119	Missense_Mutation	SNP	T	TCGA-32-2634-01A-01D-1495-08		13841119	167074141	13	16505											
PRDM9	56979	broad.mit.edu	37	chr5	23522425	23522425	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caacctagaactcaggaagaAggagactgaaagaaagatgt	11	6	1	6			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr5:23522425A>G	uc003jgo.2	+	7	703	c.521A>G	c.(520-522)AAG>AGG	p.K174R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	174					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CTCAGGAAGAAGGAGACTGAA	0.428										HNSCC(3;0.000094)			G	23522425	G	G	23522425	3	3	233	1	0	0	0	0	1	0	0	0	12463	72	3	4	543	4	PRDM9	5	23522425	Missense_Mutation	SNP	A	TCGA-32-2634-01A-01D-1495-08	9681306	23522425	157392835	14	16506											
PIK3R1	5295	broad.mit.edu	37	chr5	67591121	67591121	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcattaaaccagaccttatcCagctgagaaagacgagagac	9	10	0	4			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr5:67591121C>T	uc003jva.2	+	13	2274	c.1714C>T	c.(1714-1716)CAG>TAG	p.Q572*	PIK3R1_uc003jvb.2_Nonsense_Mutation_p.Q572*|PIK3R1_uc003jvc.2_Nonsense_Mutation_p.Q272*|PIK3R1_uc003jvd.2_Nonsense_Mutation_p.Q302*|PIK3R1_uc003jve.2_Nonsense_Mutation_p.Q251*|PIK3R1_uc011crb.1_Nonsense_Mutation_p.Q242*	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	572					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.L570_D578del(1)|p.L570_Q572del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AGACCTTATCCAGCTGAGAAA	0.373			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			T	67591121	T	T	67591121	4	4	233	1	0	0	0	0	0	1	0	0	11918	595	21	3	1890	3	PIK3R1	5	67591121	Nonsense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	44068696	67591121	113324139	15	16507											
FTMT	94033	broad.mit.edu	37	chr5	121187841	121187841	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccgggaccctaccgggccCgccgccggcccctctcgggt	13	21	1	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr5:121187841C>T	uc003kss.2	+	1	192	c.183C>T	c.(181-183)CCC>CCT	p.P61P		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	61					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		CTACCGGGCCCGCCGCCGGCC	0.736													T	121187841	T	T	121187841	2	4	233	1	0	0	0	0	0	0	0	1	6085	639	23	2		2	FTMT	5	121187841	Silent	SNP	C	TCGA-32-2634-01A-01D-1495-08	53596720	121187841	59727419	16	16508											
C5orf25	375484	broad.mit.edu	37	chr5	175717776	175717776	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctctctgtcatggaaaccCcagccagaaaagaaatatca	8	11	3	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr5:175717776C>T	uc003mds.3	+	4	1599	c.1192C>T	c.(1192-1194)CCA>TCA	p.P398S	C5orf25_uc003mdt.3_Intron|C5orf25_uc003mdr.3_Intron|C5orf25_uc011dfk.1_Missense_Mutation_p.P417S			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	398											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		CATGGAAACCCCAGCCAGAAA	0.517													T	175717776	T	T	175717776	3	4	233	1	0	0	0	0	1	0	0	0	2288	638	22	3		3	C5orf25	5	175717776	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	54529935	175717776	5197484	17	16509											
RNF130	55819	broad.mit.edu	37	chr5	179467635	179467635	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gggtttgtggatcacagcccAgatgatcagcaactgaaaag	12	8	2	3			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr5:179467635A>T	uc003mll.1	-	2	667	c.260T>A	c.(259-261)CTG>CAG	p.L87Q	RNF130_uc003mlm.1_Missense_Mutation_p.L87Q	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	87	Extracellular (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATCACAGCCCAGATGATCAGC	0.388													T	179467635	T	T	179467635	3	4	233	1	0	0	0	0	1	0	0	0	13438	188	7	5	1031	5	RNF130	5	179467635	Missense_Mutation	SNP	A	TCGA-32-2634-01A-01D-1495-08	3749859	179467635	1447625	18	16510											
PACRG	135138	broad.mit.edu	37	chr6	163235309	163235309	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaaggaaacaaaatcgcctGgaaggtaagtcagggcacag	13	7	1	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr6:163235309G>A	uc003qua.2	+	3	511	c.287G>A	c.(286-288)TGG>TAG	p.W96*	PACRG_uc003qub.2_Nonsense_Mutation_p.W96*|PACRG_uc003quc.2_Nonsense_Mutation_p.W96*	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	96											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		AAAATCGCCTGGAAGGTAAGT	0.488													A	163235309	A	A	163235309	4	1	233	1	0	0	0	0	0	1	0	0	11370	1357	47	3	293	3	PACRG	6	163235309	Nonsense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08		163235309	7879758	19	16511											
IL6	3569	broad.mit.edu	37	chr7	22769182	22769182	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcttttggagtttgaggtatAcctagagtacctccagaaca	9	8	1	3			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr7:22769182A>T	uc011jyn.1	+	5	833	c.374A>T	c.(373-375)TAC>TTC	p.Y125F	uc010kun.1_5'Flank|IL6_uc011jyo.1_Missense_Mutation_p.Y125F|IL6_uc011jyp.1_Missense_Mutation_p.Y49F|IL6_uc003svj.3_Missense_Mutation_p.Y125F|IL6_uc011jyq.1_Missense_Mutation_p.Y179F	NM_000600	NP_000591	P05231	IL6_HUMAN	interleukin 6 precursor	125					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding				0					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	TTTGAGGTATACCTAGAGTAC	0.443													T	22769182	T	T	22769182	3	4	233	1	0	0	0	0	1	0	0	0	7701	391	14	5	388	5	IL6	7	22769182	Missense_Mutation	SNP	A	TCGA-32-2634-01A-01D-1495-08		22769182	136369481	20	16512											
NOD1	10392	broad.mit.edu	37	chr7	30496383	30496383	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacaatctccgcatcttcgGccgagaagtagtcattcttc	7	13	4	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr7:30496383G>A	uc003tav.2	-	4	678	c.155C>T	c.(154-156)GCC>GTC	p.A52V	NOD1_uc010kvs.2_Missense_Mutation_p.A52V|NOD1_uc003tax.2_RNA|NOD1_uc003tay.2_RNA|NOD1_uc010kvt.2_RNA|NOD1_uc010kvu.2_RNA	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	52	CARD.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						CGCATCTTCGGCCGAGAAGTA	0.552													A	30496383	A	A	30496383	3	1	233	1	0	0	0	0	1	0	0	0	10516	1203	42	3	2750	3	NOD1	7	30496383	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08	7727201	30496383	128642280	21	16513											
ABCA13	154664	broad.mit.edu	37	chr7	48318026	48318026	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caatcaagatcttgggtcagCtcttcaccttgtaagagaat	8	9	5	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr7:48318026C>G	uc003toq.2	+	18	7260	c.7235C>G	c.(7234-7236)GCT>GGT	p.A2412G	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2412					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CTTGGGTCAGCTCTTCACCTT	0.383													G	48318026	G	G	48318026	3	3	233	1	0	0	0	0	1	0	0	0	31	797	28	5	7134	5	ABCA13	7	48318026	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	17821643	48318026	110820637	22	16514											
RABGEF1	27342	broad.mit.edu	37	chr7	66240358	66240358	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagaaattcttcagtgcatcTtccagggtcggatcaaagaa	9	8	4	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr7:66240358T>C	uc011kee.1	+	3	530	c.366T>C	c.(364-366)TCT>TCC	p.S122S	RABGEF1_uc003tvf.2_5'UTR|RABGEF1_uc003tvg.2_5'UTR|RABGEF1_uc010lag.2_Silent_p.S108S|RABGEF1_uc003tvh.2_Silent_p.S108S|RABGEF1_uc003tvi.2_5'UTR	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	286					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						TCAGTGCATCTTCCAGGGTCG	0.463													C	66240358	C	C	66240358	2	2	233	1	0	0	0	0	0	0	0	1	12966	1596	56	4		4	RABGEF1	7	66240358	Silent	SNP	T	TCGA-32-2634-01A-01D-1495-08	17922332	66240358	92898305	23	16515											
SEMA3C	10512	broad.mit.edu	37	chr7	80430136	80430136	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tatcagtttccagcagaaacAcatcctctataaaaaggaaa	5	9	2	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr7:80430136A>T	uc003uhj.2	-	10	1485	c.923T>A	c.(922-924)GTG>GAG	p.V308E	SEMA3C_uc011kgw.1_Missense_Mutation_p.V326E|SEMA3C_uc011kgx.1_Missense_Mutation_p.V160E	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	308	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						CAGCAGAAACACATCCTCTAT	0.279													T	80430136	T	T	80430136	3	4	233	1	0	0	0	0	1	0	0	0	14026	159	6	5	1368	5	SEMA3C	7	80430136	Missense_Mutation	SNP	A	TCGA-32-2634-01A-01D-1495-08	14189778	80430136	78708527	24	16516											
CACNA2D1	781	broad.mit.edu	37	chr7	81591256	81591256	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	accactgaatgatttactgtCgttatcgaagaaatactggg	9	7	0	3			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr7:81591256C>T	uc003uhr.1	-	36	3176	c.2920G>A	c.(2920-2922)GAC>AAC	p.D974N	CACNA2D1_uc011kgy.1_Missense_Mutation_p.D186N	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	986	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	GATTTACTGTCGTTATCGAAG	0.418													T	81591256	T	T	81591256	3	4	233	1	0	0	0	0	1	0	0	0	2548	884	31	2	371	2	CACNA2D1	7	81591256	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	1161120	81591256	77547407	25	16517											
TES	26136	broad.mit.edu	37	chr7	115889244	115889244	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgcaatgttatgatattgaCgaatccagttgctgccaaga	9	8	0	3			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr7:115889244C>T	uc003vho.2	+	3	465	c.284C>T	c.(283-285)ACG>ATG	p.T95M	TES_uc011kmx.1_Missense_Mutation_p.T95M|TES_uc011kmy.1_Intron|TES_uc010lka.1_Missense_Mutation_p.T86M|TES_uc003vhp.2_Missense_Mutation_p.T86M	NM_015641	NP_056456	Q9UGI8	TES_HUMAN	testin isoform 1	95	PET.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding				0	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			ATGATATTGACGAATCCAGTT	0.393													T	115889244	T	T	115889244	3	4	233	1	0	0	0	0	1	0	0	0	15762	536	19	1	294	1	TES	7	115889244	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	34297988	115889244	43249419	26	16518											
WDYHV1	55093	broad.mit.edu	37	chr8	124440173	124440173	+	Frame_Shift_Del	DEL	T	-	-													ttttatttcagtgaagaaaaTatttggaagctctgtgaata							TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr8:124440173delT	uc003yqn.1	+	2	218	c.93delT	c.(91-93)AATfs	p.N31fs	WDYHV1_uc011lij.1_5'UTR|WDYHV1_uc003yqo.1_5'Flank	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	31					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)|skin(1)	2						GTGAAGAAAATATTTGGAAGC	0.289													-	124440173	-	-	124440173	7	5	233	1	0	1	0	1	0	0	0	0	17340	1403	49	0	99	0	WDYHV1	8	124440173	Frame_Shift_Del	DEL	T	TCGA-32-2634-01A-01D-1495-08		124440173	21923849	27	16519											
PTEN	5728	broad.mit.edu	37	chr10	89692835	89692835	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttatcaaacccttttgtgaaGatcttgaccaatggctaagt	7	8	2	3	rs57374291		TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr10:89692835G>T	uc001kfb.2	+	6	1350	c.319G>T	c.(319-321)GAT>TAT	p.D107Y		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	107	Phosphatase tensin-type.		D -> Y (in BZS and glioblastoma; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.D107Y(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.D107N(1)|p.D107A(1)|p.F56fs*2(1)|p.P103fs*3(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTTTTGTGAAGATCTTGACCA	0.368		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89692835	T	T	89692835	3	4	233	1	0	0	0	0	1	0	0	0	12738	942	33	5	337	5	PTEN	10	89692835	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08		89692835	45841912	28	16520											
NFKB2	4791	broad.mit.edu	37	chr10	104158521	104158521	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gaagaggtgcagcggaagcgGaggaaggccttgcccacctt	16	10	0	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr10:104158521G>T	uc001kvb.2	+	12	1282	c.1017G>T	c.(1015-1017)CGG>CGT	p.R339R	NFKB2_uc001kva.2_Silent_p.R339R|NFKB2_uc010qqk.1_Silent_p.R339R|NFKB2_uc001kvd.2_Silent_p.R339R|NFKB2_uc009xxc.2_Silent_p.R339R	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	339	RHD.|Nuclear localization signal (Potential).				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		AGCGGAAGCGGAGGAAGGCCT	0.637			T	IGH@	B-NHL								T	104158521	T	T	104158521	2	4	233	1	0	0	0	0	0	0	0	1	10376	1161	41	5		5	NFKB2	10	104158521	Silent	SNP	G	TCGA-32-2634-01A-01D-1495-08	14465686	104158521	31376226	29	16521											
MUC5B	727897	broad.mit.edu	37	chr11	1158988	1158988	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcggccagaccggctgtgTccctgtgtcaaagtgtgcct	12	13	1	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr11:1158988T>C	uc009ycr.1	+	11	1292	c.1166T>C	c.(1165-1167)GTC>GCC	p.V389A		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACCGGCTGTGTCCCTGTGTCA	0.662													C	1158988	C	C	1158988	3	2	233	1	0	0	0	0	1	0	0	0	9979	1682	58	4		4	MUC5B	11	1158988	Missense_Mutation	SNP	T	TCGA-32-2634-01A-01D-1495-08		1158988	133847528	30	16522											
OR51L1	119682	broad.mit.edu	37	chr11	5020755	5020755	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccctctctcacgccttctgTttgcaccaggatgttctaag	8	14	4	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr11:5020755T>C	uc010qyu.1	+	1	543	c.543T>C	c.(541-543)TGT>TGC	p.C181C		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACGCCTTCTGTTTGCACCAGG	0.473													C	5020755	C	C	5020755	2	2	233	1	0	0	0	0	0	0	0	1	11102	1731	60	4		4	OR51L1	11	5020755	Silent	SNP	T	TCGA-32-2634-01A-01D-1495-08	3861767	5020755	129985761	31	16523											
OR4D6	219983	broad.mit.edu	37	chr11	59225156	59225156	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggccctctccacgtgcacGtcccacatgctggtggtgac	11	15	1	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr11:59225156G>A	uc010rku.1	+	1	723	c.723G>A	c.(721-723)ACG>ACA	p.T241T		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCACGTGCACGTCCCACATGC	0.557													A	59225156	A	A	59225156	2	1	233	1	0	0	0	0	0	0	0	1	11058	1132	40	1		1	OR4D6	11	59225156	Silent	SNP	G	TCGA-32-2634-01A-01D-1495-08	54204401	59225156	75781360	32	16524											
OR4D11	219986	broad.mit.edu	37	chr11	59271382	59271382	+	Missense_Mutation	SNP	A	T	T													acctccttggtggggcagacAttttttctctctctgtgatg							TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr11:59271382A>T	uc001noa.1	+	1	334	c.334A>T	c.(334-336)ATT>TTT	p.I112F		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGGGGCAGACATTTTTTCTCT	0.473													T	59271382	T	T	59271382	3	4	233	1	0	0	0	0	1	0	0	0	11055	217	8	5	336	5	OR4D11	11	59271382	Missense_Mutation	SNP	A	TCGA-32-2634-01A-01D-1495-08	46226	59271382	75735134	33	16525	20	2									
OR4D11	219986	broad.mit.edu	37	chr11	59271391	59271391	+	Missense_Mutation	SNP	C	G	G													gtggggcagacattttttctCtctctgtgatggcgtttgac							TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr11:59271391C>G	uc001noa.1	+	1	343	c.343C>G	c.(343-345)CTC>GTC	p.L115V		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CATTTTTTCTCTCTCTGTGAT	0.488													G	59271391	G	G	59271391	3	3	233	1	0	0	0	0	1	0	0	0	11055	913	32	5	345	5	OR4D11	11	59271391	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	9	59271391	75735125	34	16526	20	2									
CHRDL2	25884	broad.mit.edu	37	chr11	74414523	74414523	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacctccccgtgggagtacGtcttcccgccatgcacacag	9	17	1	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr11:74414523G>A	uc001ovi.2	-	8	1026	c.773C>T	c.(772-774)ACG>ATG	p.T258M	CHRDL2_uc001ovg.2_Missense_Mutation_p.T142M|CHRDL2_uc001ovh.2_Missense_Mutation_p.T258M|CHRDL2_uc001ovj.1_RNA|CHRDL2_uc001ovk.1_Intron			Q6WN34	CRDL2_HUMAN	RecName: Full=Chordin-like protein 2; AltName: Full=Chordin-related protein 2; AltName: Full=Breast tumor novel factor 1;          Short=BNF-1; Flags: Precursor;	258	VWFC 3.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion					0	Hepatocellular(1;0.098)					GTGGGAGTACGTCTTCCCGCC	0.657													A	74414523	A	A	74414523	3	1	233	1	0	0	0	0	1	0	0	0	3374	1145	40	1	602	1	CHRDL2	11	74414523	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08	15143132	74414523	60591993	35	16527											
EXPH5	23086	broad.mit.edu	37	chr11	108383232	108383232	+	Frame_Shift_Del	DEL	C	-	-													tttgatttgcttcaatgaggCtcctgtgatcactggtgggt							TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr11:108383232delC	uc001pkk.2	-	6	3113	c.3002delG	c.(3001-3003)AGCfs	p.S1001fs	EXPH5_uc010rvy.1_Frame_Shift_Del_p.S813fs|EXPH5_uc010rvz.1_Frame_Shift_Del_p.S845fs|EXPH5_uc010rwa.1_Frame_Shift_Del_p.S925fs	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1001					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTCAATGAGGCTCCTGTGATC	0.363													-	108383232	-	-	108383232	7	5	233	1	0	1	0	1	0	0	0	0	5322	797	28	0	2971	0	EXPH5	11	108383232	Frame_Shift_Del	DEL	C	TCGA-32-2634-01A-01D-1495-08	33968709	108383232	26623284	36	16528											
SIK2	23235	broad.mit.edu	37	chr11	111590592	111590592	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgatggagacctccattgacGaagggctggagacagaagga	15	7	0	5			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr11:111590592G>A	uc001plt.2	+	10	1478	c.1360G>A	c.(1360-1362)GAA>AAA	p.E454K		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	454					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						CTCCATTGACGAAGGGCTGGA	0.587													A	111590592	A	A	111590592	3	1	233	1	0	0	0	0	1	0	0	0	14318	1059	37	2	1398	2	SIK2	11	111590592	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08	3207360	111590592	23415924	37	16529											
ZBTB44	29068	broad.mit.edu	37	chr11	130130851	130130851	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gaactctgagatgcactgacAggctgggacacttcctcatg	11	11	2	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr11:130130851A>T	uc001qga.2	-	2	1312	c.918T>A	c.(916-918)CCT>CCA	p.P306P	ZBTB44_uc001qgb.3_Silent_p.P306P|ZBTB44_uc001qfx.2_RNA|ZBTB44_uc001qgc.1_Silent_p.P306P|ZBTB44_uc001qfz.2_Silent_p.P306P	NM_014155	NP_054874	Q8NCP5	ZBT44_HUMAN	zinc finger and BTB domain containing 44	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0192)|Lung(977;0.235)		ATGCACTGACAGGCTGGGACA	0.473													T	130130851	T	T	130130851	2	4	233	1	0	0	0	0	0	0	0	1	17542	175	7	5		5	ZBTB44	11	130130851	Silent	SNP	A	TCGA-32-2634-01A-01D-1495-08	18540259	130130851	4875665	38	16530											
ANO2	57101	broad.mit.edu	37	chr12	5672695	5672695	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtccgtggggatgtctggaaTcatccagtccacgaggacgc	14	11	2	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr12:5672695T>A	uc001qnm.2	-	26	2839	c.2767A>T	c.(2767-2769)ATT>TTT	p.I923F		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	928	Helical; (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						ATGTCTGGAATCATCCAGTCC	0.527													A	5672695	A	A	5672695	3	1	233	1	0	0	0	0	1	0	0	0	697	1435	50	5	233	5	ANO2	12	5672695	Missense_Mutation	SNP	T	TCGA-32-2634-01A-01D-1495-08		5672695	128179200	39	16531											
PLEKHG6	55200	broad.mit.edu	37	chr12	6436676	6436676	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgacccccaagctcctcaaCgccgaagcgcccccgaactg	8	21	1	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr12:6436676C>T	uc001qnr.2	+	15	2075	c.1927C>T	c.(1927-1929)CGC>TGC	p.R643C	PLEKHG6_uc010sew.1_Missense_Mutation_p.R643C|PLEKHG6_uc010sex.1_Missense_Mutation_p.R611C	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	643					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						AGCTCCTCAACGCCGAAGCGC	0.642													T	6436676	T	T	6436676	3	4	233	1	0	0	0	0	1	0	0	0	12074	536	19	1	2027	1	PLEKHG6	12	6436676	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	763981	6436676	127415219	40	16532											
HCFC2	29915	broad.mit.edu	37	chr12	104461817	104461817	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggacatagcttctctttataTggtaacaaatgctatttgtt	7	6	1	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr12:104461817T>C	uc001tkj.3	+	3	508	c.405T>C	c.(403-405)TAT>TAC	p.Y135Y	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	135					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						TCTCTTTATATGGTAACAAAT	0.418													C	104461817	C	C	104461817	2	2	233	1	0	0	0	0	0	0	0	1	6993	1471	51	4		4	HCFC2	12	104461817	Silent	SNP	T	TCGA-32-2634-01A-01D-1495-08	98025141	104461817	29390078	41	16533											
RB1	5925	broad.mit.edu	37	chr13	49039230	49039230	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactgaaaacaaatattttgCagtatgcttccaccagggta	8	8	0	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr13:49039230C>T	uc001vcb.2	+	22	2474	c.2308C>T	c.(2308-2310)CAG>TAG	p.Q770*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	770	Interaction with LIMD1.|Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)|p.L769fs*2(1)|p.Q770fs*24(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAATATTTTGCAGTATGCTTC	0.323		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	49039230	T	T	49039230	4	4	233	1	0	0	0	0	0	1	0	0	13098	711	25	3	2394	3	RB1	13	49039230	Nonsense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08		49039230	66130648	42	16534											
KCNRG	283518	broad.mit.edu	37	chr13	50589726	50589726	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcctgcttctcgtttggcaCgcatgttagatggcagagac	11	10	1	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr13:50589726C>T	uc001vdu.2	+	1	337	c.97C>T	c.(97-99)CGC>TGC	p.R33C	DLEU2_uc001vdn.1_Intron|DLEU2_uc001vdo.1_Intron|KCNRG_uc001vdt.2_Missense_Mutation_p.R33C|TRIM13_uc001vdp.1_3'UTR|TRIM13_uc001vdq.1_3'UTR|TRIM13_uc001vdr.1_3'UTR|TRIM13_uc001vds.1_3'UTR	NM_173605	NP_775876	Q8N5I3	KCNRG_HUMAN	potassium channel regulator isoform 1	33	BTB.					voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity				0		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.48e-10)|COAD - Colon adenocarcinoma(199;0.204)		TCGTTTGGCACGCATGTTAGA	0.408													T	50589726	T	T	50589726	3	4	233	1	0	0	0	0	1	0	0	0	8087	536	19	1	99	1	KCNRG	13	50589726	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	1550496	50589726	64580152	43	16535											
TM9SF1	10548	broad.mit.edu	37	chr14	24661549	24661549	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaacatgcccagcagtgcCatgacaataatgcctgcagg	10	11	0	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr14:24661549C>T	uc001wnb.1	-	4	1329	c.981G>A	c.(979-981)ATG>ATA	p.M327I	IPO4_uc001wmx.1_5'Flank|IPO4_uc001wmy.1_5'Flank|IPO4_uc010tnz.1_5'Flank|IPO4_uc001wmw.1_5'Flank|IPO4_uc001wmz.1_5'Flank|TM9SF1_uc010toa.1_Missense_Mutation_p.M240I|TM9SF1_uc001wna.1_RNA|TM9SF1_uc010tob.1_Missense_Mutation_p.M562I|TM9SF1_uc001wnc.2_Missense_Mutation_p.M327I|TM9SF1_uc001wnd.2_Missense_Mutation_p.M183I	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	327	Helical; (Potential).				autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		CCAGCAGTGCCATGACAATAA	0.537													T	24661549	T	T	24661549	3	4	233	1	0	0	0	0	1	0	0	0	15974	594	21	3	894	3	TM9SF1	14	24661549	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08		24661549	82687991	44	16536											
SERPINA4	5267	broad.mit.edu	37	chr14	95033524	95033524	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caaggcaaaatgagggagatTgaagaggttctgactccaga	13	6	1	6			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr14:95033524T>A	uc001ydk.2	+	3	933	c.867T>A	c.(865-867)ATT>ATA	p.I289I	SERPINA4_uc010avd.2_Silent_p.I326I|SERPINA4_uc001ydl.2_Silent_p.I289I	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	289					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		TGAGGGAGATTGAAGAGGTTC	0.468													A	95033524	A	A	95033524	2	1	233	1	0	0	0	0	0	0	0	1	14091	1800	63	5		5	SERPINA4	14	95033524	Silent	SNP	T	TCGA-32-2634-01A-01D-1495-08	70371975	95033524	12316016	45	16537											
MAP1A	4130	broad.mit.edu	37	chr15	43817784	43817784	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagttttacagcagaaagaCaaaactctggagcacaagga	10	7	1	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr15:43817784C>T	uc001zrt.2	+	4	4580	c.4113C>T	c.(4111-4113)GAC>GAT	p.D1371D		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1371						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGCAGAAAGACAAAACTCTGG	0.453													T	43817784	T	T	43817784	2	4	233	1	0	0	0	0	0	0	0	1	9227	477	17	3		3	MAP1A	15	43817784	Silent	SNP	C	TCGA-32-2634-01A-01D-1495-08		43817784	58713608	46	16538											
RNF111	54778	broad.mit.edu	37	chr15	59323149	59323149	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttttgcatccagagcccaTtggggcagccaaaagttttc	9	12	0	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr15:59323149T>C	uc002afv.2	+	2	407	c.128T>C	c.(127-129)ATT>ACT	p.I43T	RNF111_uc002afs.2_Missense_Mutation_p.I43T|RNF111_uc002aft.2_Missense_Mutation_p.I43T|RNF111_uc002afu.2_Missense_Mutation_p.I43T|RNF111_uc002afw.2_Missense_Mutation_p.I43T	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	43					multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		CCAGAGCCCATTGGGGCAGCC	0.438													C	59323149	C	C	59323149	3	2	233	1	0	0	0	0	1	0	0	0	13425	1493	52	4	130	4	RNF111	15	59323149	Missense_Mutation	SNP	T	TCGA-32-2634-01A-01D-1495-08	15505365	59323149	43208243	47	16539											
TP53	7157	broad.mit.edu	37	chr17	7577520	7577520	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggagtcttccagtgtgatgAtggtgaggatgggcctccgg	17	7	1	3			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr17:7577520A>C	uc002gim.2	-	7	955	c.761T>G	c.(760-762)ATC>AGC	p.I254S	TP53_uc002gig.1_Missense_Mutation_p.I254S|TP53_uc002gih.2_Missense_Mutation_p.I254S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.I122S|TP53_uc010cng.1_Missense_Mutation_p.I122S|TP53_uc002gii.1_Missense_Mutation_p.I122S|TP53_uc010cnh.1_Missense_Mutation_p.I254S|TP53_uc010cni.1_Missense_Mutation_p.I254S|TP53_uc002gij.2_Missense_Mutation_p.I254S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.I161S|TP53_uc002gio.2_Missense_Mutation_p.I122S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	254	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		I -> L (in a sporadic cancer; somatic mutation).|I -> D (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|I -> F (in a sporadic cancer; somatic mutation).|I -> N (in sporadic cancers; somatic mutation).|I -> S (in sporadic cancers; somatic mutation).|I -> T (in sporadic cancers; somatic mutation).|I -> V (in sporadic cancers; somatic mutation).|I -> M (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.I254F(7)|p.I254S(5)|p.I254fs*10(5)|p.I254V(4)|p.I254T(3)|p.L252_I254delLTI(3)|p.I254N(3)|p.I254D(3)|p.T253_I255del(2)|p.I254del(2)|p.I254I(1)|p.?(1)|p.I254fs*7(1)|p.I254fs*91(1)|p.I254_T256del(1)|p.R249_T256delRPILTIIT(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGTGTGATGATGGTGAGGAT	0.587		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7577520	C	C	7577520	3	2	233	1	0	0	0	0	1	0	0	0	16378	333	12	5	529	5	TP53	17	7577520	Missense_Mutation	SNP	A	TCGA-32-2634-01A-01D-1495-08		7577520	73617690	48	16540											
DHRS11	79154	broad.mit.edu	37	chr17	34951507	34951507	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccatgttctcagctatccGttctcagcacagcggtgtag	9	13	2	0	rs148449399		TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr17:34951507G>A	uc002hnd.2	+	2	468	c.254G>A	c.(253-255)CGT>CAT	p.R85H		NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	85						extracellular region	binding|oxidoreductase activity				0						TCAGCTATCCGTTCTCAGCAC	0.537													A	34951507	A	A	34951507	3	1	233	1	0	0	0	0	1	0	0	0	4487	1145	40	1	260	1	DHRS11	17	34951507	Missense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08	27373987	34951507	46243703	49	16541											
LAMA3	3909	broad.mit.edu	37	chr18	21511114	21511114	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatttttaaatctccacagaCgtatatggatggtttactgc	7	7	1	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr18:21511114C>T	uc002kuq.2	+	65	8611	c.8525C>T	c.(8524-8526)ACG>ATG	p.T2842M	LAMA3_uc002kur.2_Missense_Mutation_p.T2786M|LAMA3_uc002kus.3_Missense_Mutation_p.T1233M|LAMA3_uc002kut.3_Missense_Mutation_p.T1177M	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2842	Laminin G-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTCCACAGACGTATATGGAT	0.428													T	21511114	T	T	21511114	3	4	233	1	0	0	0	0	1	0	0	0	8607	536	19	1	8958	1	LAMA3	18	21511114	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08		21511114	56566134	50	16542											
DSC3	1825	broad.mit.edu	37	chr18	28604418	28604418	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atgggtagtgggaggggcagAtctgctgaatatccatctgc	15	7	2	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr18:28604418A>T	uc002kwj.3	-	6	827	c.672T>A	c.(670-672)GAT>GAA	p.D224E	DSC3_uc002kwi.3_Missense_Mutation_p.D224E	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	224	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GGAGGGGCAGATCTGCTGAAT	0.398													T	28604418	T	T	28604418	3	4	233	1	0	0	0	0	1	0	0	0	4767	330	12	5	2093	5	DSC3	18	28604418	Missense_Mutation	SNP	A	TCGA-32-2634-01A-01D-1495-08	7093304	28604418	49472830	51	16543											
ANKRD24	170961	broad.mit.edu	37	chr19	4207777	4207777	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtagccccctcccctggtaGgacggccctgatgctggcct	12	16	0	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr19:4207777G>A	uc010dtt.1	+	10	921	c.645_splice	c.e10-1	p.R215_splice	ANKRD24_uc002lzs.2_Splice_Site_p.R186_splice|ANKRD24_uc002lzt.2_Splice_Site_p.R187_splice	NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24												0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TCCCCTGGTAGGACGGCCCTG	0.682											OREG0025162	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	4207777	A	A	4207777	5	1	233	1	0	0	0	0	0	0	1	0	653	1014	35	3	678	3	ANKRD24	19	4207777	Splice_Site	SNP	G	TCGA-32-2634-01A-01D-1495-08		4207777	54921206	52	16544											
CACNA1A	773	broad.mit.edu	37	chr19	13355996	13355996	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagctggagggagacttacCccaaactcagtcacgaggat	12	10	2	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr19:13355996C>T	uc010dze.2	-	31	5189	c.4953G>A	c.(4951-4953)GGG>GGA	p.G1651G	CACNA1A_uc010xnd.1_Silent_p.G356G|CACNA1A_uc002mwx.3_Silent_p.G356G|CACNA1A_uc010dzc.2_Silent_p.G1176G|CACNA1A_uc002mwy.3_Silent_p.G1650G|CACNA1A_uc010xne.1_Silent_p.G1179G|CACNA1A_uc002mwv.3_Silent_p.G167G	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1651	Extracellular (Potential).|IV.			G -> GNP (in Ref. 1; AAB61613/AAB61612).	cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGAGACTTACCCCAAACTCAG	0.597													T	13355996	T	T	13355996	2	4	233	1	0	0	0	0	0	0	0	1	2538	637	22	3		3	CACNA1A	19	13355996	Silent	SNP	C	TCGA-32-2634-01A-01D-1495-08	9148219	13355996	45772987	53	16545											
ATP4A	495	broad.mit.edu	37	chr19	36051416	36051416	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccgccaggatgcggatgtcGgcgggcactctgtccccacc	14	16	1	0	rs149880813		TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr19:36051416G>A	uc002oal.1	-	6	665	c.636C>T	c.(634-636)GCC>GCT	p.A212A	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	212	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TGCGGATGTCGGCGGGCACTC	0.622													A	36051416	A	A	36051416	2	1	233	1	0	0	0	0	0	0	0	1	1145	1103	39	2		2	ATP4A	19	36051416	Silent	SNP	G	TCGA-32-2634-01A-01D-1495-08	22695420	36051416	23077567	54	16546											
EPS8L1	54869	broad.mit.edu	37	chr19	55593671	55593671	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgcggcaacatcgccgaccCctcctctccggagctgttgc	11	18	1	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr19:55593671C>T	uc002qis.3	+	11	1123	c.1019C>T	c.(1018-1020)CCC>CTC	p.P340L	EPS8L1_uc010ess.1_Missense_Mutation_p.P322L|EPS8L1_uc010est.1_Missense_Mutation_p.P340L|EPS8L1_uc010yfr.1_Missense_Mutation_p.P276L|EPS8L1_uc010esu.1_RNA|EPS8L1_uc002qiu.2_Missense_Mutation_p.P213L|EPS8L1_uc002qiv.2_5'UTR|EPS8L1_uc002qiw.2_Missense_Mutation_p.P87L	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway	340						cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ATCGCCGACCCCTCCTCTCCG	0.662													T	55593671	T	T	55593671	3	4	233	1	0	0	0	0	1	0	0	0	5195	623	22	3	1109	3	EPS8L1	19	55593671	Missense_Mutation	SNP	C	TCGA-32-2634-01A-01D-1495-08	19542255	55593671	3535312	55	16547											
ZFP28	140612	broad.mit.edu	37	chr19	57066095	57066095	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggagagaagccctatgaatgTaaggtttgtagtaaagcgtt	13	4	0	2			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr19:57066095T>G	uc002qnj.2	+	8	2012	c.1941T>G	c.(1939-1941)TGT>TGG	p.C647W	uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	647	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		CCTATGAATGTAAGGTTTGTA	0.458													G	57066095	G	G	57066095	3	3	233	1	0	0	0	0	1	0	0	0	17639	1644	57	5	1971	5	ZFP28	19	57066095	Missense_Mutation	SNP	T	TCGA-32-2634-01A-01D-1495-08	1472424	57066095	2062888	56	16548											
NSFL1C	55968	broad.mit.edu	37	chr20	1424444	1424444	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcaggttggcttccttcaGggtctggctctcatcagcca	12	12	4	0			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chr20:1424444G>A	uc002wfc.2	-	9	2011	c.1063C>T	c.(1063-1065)CTG>TTG	p.L355L	NSFL1C_uc002wfd.2_Silent_p.L244L|NSFL1C_uc002wfe.2_Silent_p.L324L|NSFL1C_uc002wff.2_RNA|NSFL1C_uc010gag.2_Silent_p.L121L	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	355	UBX.					chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						GCTTCCTTCAGGGTCTGGCTC	0.582													A	1424444	A	A	1424444	2	1	233	1	0	0	0	0	0	0	0	1	10672	991	35	3		3	NSFL1C	20	1424444	Silent	SNP	G	TCGA-32-2634-01A-01D-1495-08		1424444	61601076	57	16549											
SLC6A14	11254	broad.mit.edu	37	chrX	115573956	115573956	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tgtttgcttcttttcaaagtGaactaccatggaaaaattgt	7	6	2	1			TCGA-32-2634-01A-01D-1495-08	TCGA-32-2634-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	52b2a114-4f8c-4e02-af9d-24c4a05d4ca0	9157adef-f3b4-43a8-bf98-ee22bfc4631f	g.chrX:115573956G>T	uc004eqi.2	+	4	552	c.448G>T	c.(448-450)GAA>TAA	p.E150*	SLC6A14_uc011mtm.1_RNA	NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	150	Extracellular (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TTTTCAAAGTGAACTACCATG	0.323													T	115573956	T	T	115573956	4	4	233	1	0	0	0	0	0	1	0	0	14677	1291	45	5	462	5	SLC6A14	23	115573956	Nonsense_Mutation	SNP	G	TCGA-32-2634-01A-01D-1495-08		115573956	39696604	58	16550											
UBE2U	148581	broad.mit.edu	37	chr1	64707415	64707418	+	Splice_Site	DEL	AAGT	-	-													atcagaaagaatggaatttaAagtaagaaatatgaagtgcc							TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr1:64707415_64707418delAAGT	uc001dbn.1	+	8	921	c.677_splice	c.e8+1	p.K226_splice		NM_152489	NP_689702	Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)								ATP binding|protein binding|ubiquitin-protein ligase activity				0						ATGGAATTTAAAGTAAGAAATATG	0.304													-	64707418	-	-	64707415	8	5	234	1	0	1	0	1	0	0	1	0	16871	28	1	0	706	0	UBE2U	1	64707415	Splice_Site	DEL	AAGT	TCGA-32-2638-01A-01D-1495-08		64707415	184543206	1	16551											
AMPD1	270	broad.mit.edu	37	chr1	115221096	115221096	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtaagatttcttaataaaaCgcagcagatgtttctggttc	9	6	2	2	rs142123340	by1000genomes	TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr1:115221096C>T	uc001efe.1	-	8	1034	c.950G>A	c.(949-951)CGT>CAT	p.R317H	AMPD1_uc001eff.1_Missense_Mutation_p.R313H	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	317					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	CTTAATAAAACGCAGCAGATG	0.368													T	115221096	T	T	115221096	3	4	234	1	0	0	0	0	1	0	0	0	585	536	19	1	1329	1	AMPD1	1	115221096	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	50513681	115221096	134029525	2	16552											
ASH1L	55870	broad.mit.edu	37	chr1	155449241	155449241	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgaatcatactgccctgtctGgagtgtaaatgcaaatatgg	10	7	2	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr1:155449241G>C	uc009wqq.2	-	3	3900	c.3420C>G	c.(3418-3420)TCC>TCG	p.S1140S	ASH1L_uc001fkt.2_Silent_p.S1140S|ASH1L_uc009wqr.1_Silent_p.S1140S	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1140					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TGCCCTGTCTGGAGTGTAAAT	0.478													C	155449241	C	C	155449241	2	2	234	1	0	0	0	0	0	0	0	1	1041	1335	47	5		5	ASH1L	1	155449241	Silent	SNP	G	TCGA-32-2638-01A-01D-1495-08	40228145	155449241	93801380	3	16553											
SEC16B	89866	broad.mit.edu	37	chr1	177937026	177937026	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggacaggccgatgatgtcCatctctccgaaaccctcggt	11	13	1	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr1:177937026C>T	uc001gli.1	-	2	181	c.91G>A	c.(91-93)GGA>AGA	p.G31R	SEC16B_uc001glk.1_5'UTR|SEC16B_uc009wwz.1_5'UTR|SEC16B_uc001glj.1_Missense_Mutation_p.G31R|SEC16B_uc001gll.3_Missense_Mutation_p.G31R	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	31					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						CGATGATGTCCATCTCTCCGA	0.602													T	177937026	T	T	177937026	3	4	234	1	0	0	0	0	1	0	0	0	13987	603	21	3	3191	3	SEC16B	1	177937026	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	22487785	177937026	71313595	4	16554											
USH2A	7399	broad.mit.edu	37	chr1	216595556	216595556	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttcttgaaagctcccacgttCtccagccttgggaaaagacc	8	13	2	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr1:216595556C>T	uc001hku.1	-	2	510	c.123G>A	c.(121-123)GAG>GAA	p.E41E	USH2A_uc001hkv.2_Silent_p.E41E	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	41	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTCCCACGTTCTCCAGCCTTG	0.473										HNSCC(13;0.011)			T	216595556	T	T	216595556	2	4	234	1	0	0	0	0	0	0	0	1	17033	912	32	3		3	USH2A	1	216595556	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	38658530	216595556	32655065	5	16555											
C1orf69	200205	broad.mit.edu	37	chr1	228362953	228362953	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gagctgacggcccgcacccaCcacatgggcgtcatccgcaa	11	17	1	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr1:228362953C>A	uc001hsl.3	+	3	899	c.810C>A	c.(808-810)CAC>CAA	p.H270Q	C1orf69_uc010pvw.1_Missense_Mutation_p.H77Q	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	270					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CCCGCACCCACCACATGGGCG	0.652													A	228362953	A	A	228362953	3	1	234	1	0	0	0	0	1	0	0	0	2057	506	18	5	820	5	C1orf69	1	228362953	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	11767397	228362953	20887668	6	16556											
OBSCN	84033	broad.mit.edu	37	chr1	228564891	228564891	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaagggcctgcgccacccGcacctggcccagctgcacgc	11	20	1	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr1:228564891G>A	uc009xez.1	+	101	23222	c.23178G>A	c.(23176-23178)CCG>CCA	p.P7726P	OBSCN_uc001hsr.1_Silent_p.P2355P	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	7726	Protein kinase 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGCGCCACCCGCACCTGGCCC	0.697													A	228564891	A	A	228564891	2	1	234	1	0	0	0	0	0	0	0	1	10812	1074	38	1		1	OBSCN	1	228564891	Silent	SNP	G	TCGA-32-2638-01A-01D-1495-08	201938	228564891	20685730	7	16557											
ZP4	57829	broad.mit.edu	37	chr1	238048807	238048807	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgaaggatggagacctcCacgtaaatgggatcccgaag	13	9	0	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr1:238048807C>G	uc001hym.2	-	8	1044	c.1044G>C	c.(1042-1044)GTG>GTC	p.V348V	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	348	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TGGAGACCTCCACGTAAATGG	0.522													G	238048807	G	G	238048807	2	3	234	1	0	0	0	0	0	0	0	1	18215	581	21	5		5	ZP4	1	238048807	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	9483916	238048807	11201814	8	16558											
DTNB	1838	broad.mit.edu	37	chr2	25674485	25674485	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acggtgttcctcatccagtcGgctaggactgtccagaacac	10	13	1	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr2:25674485G>A	uc002rgh.2	-	12	1439	c.1189C>T	c.(1189-1191)CGA>TGA	p.R397*	DTNB_uc002rgg.2_Nonsense_Mutation_p.R26*|DTNB_uc010yko.1_Nonsense_Mutation_p.R340*|DTNB_uc010ykp.1_Nonsense_Mutation_p.R193*|DTNB_uc002rgo.2_Nonsense_Mutation_p.R188*|DTNB_uc002rgi.2_Nonsense_Mutation_p.R397*|DTNB_uc002rgj.2_Nonsense_Mutation_p.R397*|DTNB_uc002rgk.2_Nonsense_Mutation_p.R367*|DTNB_uc002rgl.2_Nonsense_Mutation_p.R367*|DTNB_uc002rgq.2_Nonsense_Mutation_p.R397*|DTNB_uc002rgm.2_Nonsense_Mutation_p.R367*|DTNB_uc002rgn.2_Nonsense_Mutation_p.R193*|DTNB_uc002rgr.1_Nonsense_Mutation_p.R386*|DTNB_uc010ykq.1_Nonsense_Mutation_p.R250*	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	397						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCATCCAGTCGGCTAGGACTG	0.468													A	25674485	A	A	25674485	4	1	234	1	0	0	0	0	0	1	0	0	4789	1124	39	2	730	2	DTNB	2	25674485	Nonsense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08		25674485	217524888	9	16559											
DUSP11	8446	broad.mit.edu	37	chr2	74007043	74007043	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccttcttcttggctgaggagCgtcctgaaaagtcgcgtctc	11	12	3	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr2:74007043C>A	uc002sjp.2	-	1	242	c.200G>T	c.(199-201)CGC>CTC	p.R67L	DUSP11_uc002sjq.3_Missense_Mutation_p.R67L	NM_003584	NP_003575	O75319	DUS11_HUMAN	dual specificity phosphatase 11	20					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			skin(1)	1						GGCTGAGGAGCGTCCTGAAAA	0.617											OREG0014714	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	74007043	A	A	74007043	3	1	234	1	0	0	0	0	1	0	0	0	4811	768	27	5	969	5	DUSP11	2	74007043	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	48332558	74007043	169192330	10	16560											
MAP4K4	9448	broad.mit.edu	37	chr2	102483026	102483026	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcagagtggctccggggaaCgcttcagagtgagatgtaag	15	8	2	3			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr2:102483026C>T	uc002tbg.2	+	18	2162	c.2107C>T	c.(2107-2109)CGC>TGC	p.R703C	MAP4K4_uc002tbc.2_Missense_Mutation_p.R781C|MAP4K4_uc002tbd.2_Missense_Mutation_p.R673C|MAP4K4_uc002tbe.2_Missense_Mutation_p.R619C|MAP4K4_uc002tbf.2_Missense_Mutation_p.R673C|MAP4K4_uc010yvy.1_Missense_Mutation_p.R696C|MAP4K4_uc002tbh.2_Missense_Mutation_p.R618C|MAP4K4_uc002tbi.2_Missense_Mutation_p.R503C|MAP4K4_uc010yvz.1_Missense_Mutation_p.R676C|MAP4K4_uc002tbk.2_Missense_Mutation_p.R158C|MAP4K4_uc002tbl.2_Translation_Start_Site	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	703					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CTCCGGGGAACGCTTCAGAGT	0.532													T	102483026	T	T	102483026	3	4	234	1	0	0	0	0	1	0	0	0	9262	536	19	1	2415	1	MAP4K4	2	102483026	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	28475983	102483026	140716347	11	16561											
ZAK	51776	broad.mit.edu	37	chr2	174131422	174131422	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccccacaggccatctcccGccaaaaccaataaagagaga	7	15	1	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr2:174131422G>A	uc002uhz.2	+	20	2547	c.2347G>A	c.(2347-2349)GCC>ACC	p.A783T	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	783					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			GCCATCTCCCGCCAAAACCAA	0.473													A	174131422	A	A	174131422	3	1	234	1	0	0	0	0	1	0	0	0	17509	1087	38	1	2806	1	ZAK	2	174131422	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08	71648396	174131422	69067951	12	16562											
MYO1B	4430	broad.mit.edu	37	chr2	192261188	192261188	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accagcagacaaagagttccGccttagtaattcagtcttat	7	10	2	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr2:192261188G>A	uc010fsg.2	+	21	2515	c.2260G>A	c.(2260-2262)GCC>ACC	p.A754T	MYO1B_uc002usq.2_Missense_Mutation_p.A754T|MYO1B_uc002usr.2_Missense_Mutation_p.A754T|MYO1B_uc002usu.2_Missense_Mutation_p.A28T	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	754	IQ 3.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			AAAGAGTTCCGCCTTAGTAAT	0.373													A	192261188	A	A	192261188	3	1	234	1	0	0	0	0	1	0	0	0	10069	1087	38	1	2338	1	MYO1B	2	192261188	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08	18129766	192261188	50938185	13	16563											
ZNF385D	79750	broad.mit.edu	37	chr3	21792472	21792472	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctcacccaaggctggcacGtagagcagagccctttcatg	10	14	2	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr3:21792472G>A	uc003cce.2	-	1	345	c.-63C>T	c.(-65--61)TACGT>TATGT		ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D							nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						AGGCTGGCACGTAGAGCAGAG	0.557													A	21792472	A	A	21792472	1	1	234	1	0	0	0	0	0	0	0	0	17875	1160	40	1		1	ZNF385D	3	21792472	Translation_Start_Site	SNP	G	TCGA-32-2638-01A-01D-1495-08		21792472	176229958	14	16564											
SUCLG2	8801	broad.mit.edu	37	chr3	67570993	67570993	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	accagcacggggccattgcaGgaccggtccatcagaattgc	12	13	1	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr3:67570993G>C	uc003dna.3	-	5	511	c.483C>G	c.(481-483)TCC>TCG	p.S161S	SUCLG2_uc010hob.2_Silent_p.S42S	NM_003848	NP_003839	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming beta subunit	161	ATP-grasp.				succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|skin(1)	2		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	GGCCATTGCAGGACCGGTCCA	0.502													C	67570993	C	C	67570993	2	2	234	1	0	0	0	0	0	0	0	1	15364	987	35	5		5	SUCLG2	3	67570993	Silent	SNP	G	TCGA-32-2638-01A-01D-1495-08	45778521	67570993	130451437	15	16565											
IFT122	55764	broad.mit.edu	37	chr3	129214370	129214370	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggggaagttccatgaggccGccaaactgtacaagaggagt	14	8	0	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr3:129214370G>A	uc003emm.2	+	18	2334	c.2128G>A	c.(2128-2130)GCC>ACC	p.A710T	IFT122_uc003eml.2_Missense_Mutation_p.A761T|IFT122_uc003emn.2_Missense_Mutation_p.A651T|IFT122_uc003emo.2_Missense_Mutation_p.A599T|IFT122_uc003emp.2_Missense_Mutation_p.A560T|IFT122_uc010htc.2_Missense_Mutation_p.A702T|IFT122_uc011bky.1_Missense_Mutation_p.A501T|IFT122_uc003emq.2_Missense_Mutation_p.A550T|IFT122_uc003emr.2_Missense_Mutation_p.A462T|IFT122_uc011bla.1_Missense_Mutation_p.A483T|IFT122_uc010hte.2_Intron|IFT122_uc003ems.2_Missense_Mutation_p.A91T|IFT122_uc011bkx.1_Missense_Mutation_p.A550T|IFT122_uc010htd.1_Missense_Mutation_p.A189T	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	710					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						CCATGAGGCCGCCAAACTGTA	0.512													A	129214370	A	A	129214370	3	1	234	1	0	0	0	0	1	0	0	0	7555	1087	38	1	2355	1	IFT122	3	129214370	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08	61643377	129214370	68808060	16	16566											
GRK7	131890	broad.mit.edu	37	chr3	141497201	141497201	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccggaagccctcggactgCgacagcaaagagctgcagcg	14	14	0	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr3:141497201C>T	uc011bnd.1	+	1	159	c.75C>T	c.(73-75)TGC>TGT	p.C25C		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	25					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						CCTCGGACTGCGACAGCAAAG	0.701													T	141497201	T	T	141497201	2	4	234	1	0	0	0	0	0	0	0	1	6794	776	27	1		1	GRK7	3	141497201	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	12282831	141497201	56525229	17	16567											
TM4SF1	4071	broad.mit.edu	37	chr3	149093335	149093335	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	caatgacacagtagccagatCctgcaattccaatgagagca	8	11	0	3			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr3:149093335C>G	uc003exb.1	-	3	542	c.308G>C	c.(307-309)GGA>GCA	p.G103A	TM4SF1_uc003exc.1_Missense_Mutation_p.G14A	NM_014220	NP_055035	P30408	T4S1_HUMAN	transmembrane 4 superfamily member 1	103	Helical; (Probable).					integral to plasma membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GTAGCCAGATCCTGCAATTCC	0.507													G	149093335	G	G	149093335	3	3	234	1	0	0	0	0	1	0	0	0	15963	855	30	5	312	5	TM4SF1	3	149093335	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	7596134	149093335	48929095	18	16568											
ADAMTS3	9508	broad.mit.edu	37	chr4	73184402	73184402	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atcatgatcaaaagggtcatCaaggagacagtcataggaac	10	7	5	2	rs80237783		TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr4:73184402C>G	uc003hgk.1	-	10	1409	c.1372G>C	c.(1372-1374)GAT>CAT	p.D458H		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	458	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AAAGGGTCATCAAGGAGACAG	0.343													G	73184402	G	G	73184402	3	3	234	1	0	0	0	0	1	0	0	0	267	826	29	5	2297	5	ADAMTS3	4	73184402	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08		73184402	117969874	19	16569											
MRPL1	65008	broad.mit.edu	37	chr4	78804480	78804480	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaaaataaaagcatatccCtatatggaaggcgaacctga	8	7	0	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr4:78804480C>T	uc003hku.2	+	3	426	c.228C>T	c.(226-228)CCC>CCT	p.P76P	MRPL1_uc010iji.1_5'UTR	NM_020236	NP_064621	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1 precursor	76							RNA binding				0						AAGCATATCCCTATATGGAAG	0.323													T	78804480	T	T	78804480	2	4	234	1	0	0	0	0	0	0	0	1	9774	668	24	3		3	MRPL1	4	78804480	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	5620078	78804480	112349796	20	16570											
UNC5C	8633	broad.mit.edu	37	chr4	96090460	96090460	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaagacagctgccagcatGctcaggtttccatctgggaa	10	12	2	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr4:96090460G>A	uc003htp.1	-	16	2875	c.2721C>T	c.(2719-2721)AGC>AGT	p.S907S	uc003hto.2_5'Flank	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	907	Cytoplasmic (Potential).|Death.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CTGCCAGCATGCTCAGGTTTC	0.483													A	96090460	A	A	96090460	2	1	234	1	0	0	0	0	0	0	0	1	16990	1310	46	3		3	UNC5C	4	96090460	Silent	SNP	G	TCGA-32-2638-01A-01D-1495-08	17285980	96090460	95063816	21	16571											
NAF1	92345	broad.mit.edu	37	chr4	164054388	164054388	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttggcttccttctctttttcAtcatcactaaaatctaaggc	4	11	5	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr4:164054388A>G	uc003iqj.2	-	7	1145	c.951T>C	c.(949-951)GAT>GAC	p.D317D	NAF1_uc010iqw.1_Silent_p.D317D	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	317					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				TCTCTTTTTCATCATCACTAA	0.333													G	164054388	G	G	164054388	2	3	234	1	0	0	0	0	0	0	0	1	10140	214	8	4		4	NAF1	4	164054388	Silent	SNP	A	TCGA-32-2638-01A-01D-1495-08	67963928	164054388	27099888	22	16572											
ODZ3	55714	broad.mit.edu	37	chr4	183574978	183574978	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcagactgaaaatgacacatTtgagaatggaaaagtgaatt	10	4	0	5			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr4:183574978T>C	uc003ivd.1	+	5	1080	c.1043T>C	c.(1042-1044)TTT>TCT	p.F348S		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	348	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AATGACACATTTGAGAATGGA	0.418													C	183574978	C	C	183574978	3	2	234	1	0	0	0	0	1	0	0	0	10836	1841	64	4	1061	4	ODZ3	4	183574978	Missense_Mutation	SNP	T	TCGA-32-2638-01A-01D-1495-08	19520590	183574978	7579298	23	16573											
SH3RF2	153769	broad.mit.edu	37	chr5	145393517	145393517	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtccattctccttcagggCgccatatggtagagatcagc	11	11	3	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr5:145393517C>T	uc003lnt.2	+	5	1190	c.952C>T	c.(952-954)CGC>TGC	p.R318C	SH3RF2_uc011dbl.1_Missense_Mutation_p.R318C	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	318							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCTTCAGGGCGCCATATGGT	0.577													T	145393517	T	T	145393517	3	4	234	1	0	0	0	0	1	0	0	0	14259	768	27	1	966	1	SH3RF2	5	145393517	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08		145393517	35521743	24	16574											
FRK	2444	broad.mit.edu	37	chr6	116265439	116265439	+	Frame_Shift_Del	DEL	C	-	-													ggcaagtccaaaatctgctaCtttgtagatattatgttcac							TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr6:116265439delC	uc003pwi.1	-	6	1555	c.1108delG	c.(1108-1110)GTAfs	p.V370fs		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	370	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		AAATCTGCTACTTTGTAGATA	0.388													-	116265439	-	-	116265439	7	5	234	1	0	1	0	1	0	0	0	0	6048	565	20	0	421	0	FRK	6	116265439	Frame_Shift_Del	DEL	C	TCGA-32-2638-01A-01D-1495-08		116265439	54849628	25	16575											
NKAIN2	154215	broad.mit.edu	37	chr6	124979424	124979424	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acggtgacgtcagtgacaccTgccccagactgggccccaga	12	15	1	4			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr6:124979424T>A	uc003pzo.2	+	4	643	c.366T>A	c.(364-366)CCT>CCA	p.P122P	NKAIN2_uc003pzn.1_Silent_p.P122P|NKAIN2_uc003pzp.2_Silent_p.P121P|NKAIN2_uc010keq.2_Intron|NKAIN2_uc010ker.2_Silent_p.P32P	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	122						integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		CAGTGACACCTGCCCCAGACT	0.502													A	124979424	A	A	124979424	2	1	234	1	0	0	0	0	0	0	0	1	10436	1567	55	5		5	NKAIN2	6	124979424	Silent	SNP	T	TCGA-32-2638-01A-01D-1495-08	8713985	124979424	46135643	26	16576											
NOX3	50508	broad.mit.edu	37	chr6	155743923	155743923	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactccgatccccgcggcaaCgcacacacacactgggtagt	10	16	0	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr6:155743923C>T	uc003qqm.2	-	10	1316	c.1213G>A	c.(1213-1215)GTT>ATT	p.V405I		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	405	Helical; (Potential).						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CCCGCGGCAACGCACACACAC	0.537													T	155743923	T	T	155743923	3	4	234	1	0	0	0	0	1	0	0	0	10557	536	19	1	509	1	NOX3	6	155743923	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	30764499	155743923	15371144	27	16577											
PLG	5340	broad.mit.edu	37	chr6	161134138	161134138	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaagagatatgactactgCgacattcttgagtgtgaagg	12	5	1	4			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr6:161134138C>T	uc003qtm.3	+	5	591	c.528C>T	c.(526-528)TGC>TGT	p.C176C		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	176	Kringle 1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATGACTACTGCGACATTCTTG	0.473													T	161134138	T	T	161134138	2	4	234	1	0	0	0	0	0	0	0	1	12086	776	27	1		1	PLG	6	161134138	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	5390215	161134138	9980929	28	16578											
NPC1L1	29881	broad.mit.edu	37	chr7	44560418	44560418	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgctgtatgctgccaggcCgctgcaagaaggtcagggca	16	10	1	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr7:44560418C>T	uc003tlb.2	-	14	3138	c.3082G>A	c.(3082-3084)GGC>AGC	p.G1028S	NPC1L1_uc003tlc.2_Missense_Mutation_p.G1028S|NPC1L1_uc011kbw.1_Missense_Mutation_p.G982S|NPC1L1_uc003tla.2_Missense_Mutation_p.G31S	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1028	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCTGCCAGGCCGCTGCAAGAA	0.572													T	44560418	T	T	44560418	3	4	234	1	0	0	0	0	1	0	0	0	10571	666	23	2	1025	2	NPC1L1	7	44560418	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08		44560418	114578245	29	16579											
CACNA2D1	781	broad.mit.edu	37	chr7	81594957	81594957	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	catcagaagaaacccaccatCatccagaatcacacaatcca	3	15	3	3			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr7:81594957C>T	uc003uhr.1	-	32	2783	c.2527G>A	c.(2527-2529)GAT>AAT	p.D843N	CACNA2D1_uc011kgy.1_Missense_Mutation_p.D55N	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	855	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AACCCACCATCATCCAGAATC	0.368													T	81594957	T	T	81594957	3	4	234	1	0	0	0	0	1	0	0	0	2548	826	29	3	780	3	CACNA2D1	7	81594957	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	37034539	81594957	77543706	30	16580											
ZNF804B	219578	broad.mit.edu	37	chr7	88965893	88965893	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaaccgtacagacagttccAgttcaccagcacacttctat	5	14	3	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr7:88965893A>G	uc011khi.1	+	4	4135	c.3597A>G	c.(3595-3597)CCA>CCG	p.P1199P		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1199						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGACAGTTCCAGTTCACCAGC	0.502										HNSCC(36;0.09)			G	88965893	G	G	88965893	2	3	234	1	0	0	0	0	0	0	0	1	18168	175	7	4		4	ZNF804B	7	88965893	Silent	SNP	A	TCGA-32-2638-01A-01D-1495-08	7370936	88965893	70172770	31	16581											
MUC17	140453	broad.mit.edu	37	chr7	100680859	100680859	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtatgcctgtcagcactacGcttgtggtcagttctgaggg	14	9	3	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr7:100680859G>A	uc003uxp.1	+	3	6215	c.6162G>A	c.(6160-6162)ACG>ACA	p.T2054T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2054	Extracellular (Potential).|32.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAGCACTACGCTTGTGGTCA	0.493													A	100680859	A	A	100680859	2	1	234	1	0	0	0	0	0	0	0	1	9974	1074	38	1		1	MUC17	7	100680859	Silent	SNP	G	TCGA-32-2638-01A-01D-1495-08	11714966	100680859	58457804	32	16582											
TFEC	22797	broad.mit.edu	37	chr7	115590932	115590932	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgattgttgaactcacggatCattagactttggaataagag	10	5	2	4			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr7:115590932C>T	uc003vhj.1	-	6	695	c.511G>A	c.(511-513)GAT>AAT	p.D171N	TFEC_uc003vhk.1_Missense_Mutation_p.D142N|TFEC_uc003vhl.3_Missense_Mutation_p.D142N|TFEC_uc011kmw.1_Missense_Mutation_p.D261N	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	171	Helix-loop-helix motif.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			ACTCACGGATCATTAGACTTT	0.323													T	115590932	T	T	115590932	3	4	234	1	0	0	0	0	1	0	0	0	15799	826	29	3	544	3	TFEC	7	115590932	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	14910073	115590932	43547731	33	16583											
CDKN2A	1029	broad.mit.edu	37	chr9	21971029	21971029	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtccacgggcagacggcccCaggcatcgcgcacgtccagc	14	17	0	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr9:21971029C>T	uc003zpk.2	-	2	541	c.329G>A	c.(328-330)TGG>TAG	p.W110*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.L165L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	110	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.W110*(38)|p.?(13)|p.H83fs*2(2)|p.W110fs*9(1)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)|p.W110fs*36(1)|p.W110C(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CAGACGGCCCCAGGCATCGCG	0.731		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			T	21971029	T	T	21971029	4	4	234	1	0	0	0	0	0	1	0	0	3161	595	21	3	149	3	CDKN2A	9	21971029	Nonsense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08		21971029	119242402	34	16584											
IKBKAP	8518	broad.mit.edu	37	chr9	111659518	111659518	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gatccctggacaggtagacaCtgctggtaactggtgcaggg	15	9	0	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr9:111659518C>A	uc004bdm.3	-	23	2931	c.2411G>T	c.(2410-2412)AGT>ATT	p.S804I	IKBKAP_uc004bdl.2_Missense_Mutation_p.S455I|IKBKAP_uc011lwc.1_Missense_Mutation_p.S690I|IKBKAP_uc010mtq.2_Missense_Mutation_p.S455I	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	804					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						CAGGTAGACACTGCTGGTAAC	0.463													A	111659518	A	A	111659518	3	1	234	1	0	0	0	0	1	0	0	0	7610	565	20	5	1647	5	IKBKAP	9	111659518	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	89688489	111659518	29553913	35	16585											
EHMT1	79813	broad.mit.edu	37	chr9	140638536	140638536	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atgtcggaggctgatcgcgcCcagaaggtatgtgttgctgt	15	8	0	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr9:140638536C>A	uc011mfc.1	+	6	1201	c.1164C>A	c.(1162-1164)GCC>GCA	p.A388A	EHMT1_uc004coa.2_Silent_p.A388A|EHMT1_uc004cob.1_Silent_p.A357A	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	388					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CTGATCGCGCCCAGAAGGTAT	0.567													A	140638536	A	A	140638536	2	1	234	1	0	0	0	0	0	0	0	1	4983	610	22	5		5	EHMT1	9	140638536	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	28979018	140638536	574895	36	16586											
KIAA1462	57608	broad.mit.edu	37	chr10	30336587	30336587	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttacgatgtgcgagggccGcagggccatcctcatgcccg	13	14	2	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr10:30336587G>A	uc001iux.2	-	1	214	c.155C>T	c.(154-156)GCG>GTG	p.A52V	KIAA1462_uc001iuy.2_Missense_Mutation_p.A52V|KIAA1462_uc001iuz.2_5'UTR|KIAA1462_uc009xle.1_Missense_Mutation_p.A52V	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	52										ovary(4)	4						TGCGAGGGCCGCAGGGCCATC	0.677													A	30336587	A	A	30336587	3	1	234	1	0	0	0	0	1	0	0	0	8234	1087	38	1	3936	1	KIAA1462	10	30336587	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08		30336587	105198160	37	16587											
LRDD	55367	broad.mit.edu	37	chr11	800341	800341	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccctcgcccacctggccccGcacagcctgagcctcccggt	9	23	0	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:800341G>A	uc001lro.1	-	13	2294	c.2152C>T	c.(2152-2154)CGG>TGG	p.R718W	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_Intron|LRDD_uc001lrk.1_Intron|LRDD_uc001lrl.1_Missense_Mutation_p.R561W|LRDD_uc001lrm.1_Missense_Mutation_p.R405W|LRDD_uc001lrn.1_Missense_Mutation_p.R561W|LRDD_uc001lrp.1_Intron	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	718					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACCTGGCCCCGCACAGCCTGA	0.627													A	800341	A	A	800341	3	1	234	1	0	0	0	0	1	0	0	0	8936	1086	38	1	596	1	LRDD	11	800341	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08		800341	134206175	38	16588											
OR51T1	401665	broad.mit.edu	37	chr11	4904033	4904033	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttgaagaccaagacaatcCgccaggctatgttccagctg	10	12	0	3			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:4904033C>T	uc010qyp.1	+	1	985	c.985C>T	c.(985-987)CGC>TGC	p.R329C		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAAGACAATCCGCCAGGCTAT	0.488													T	4904033	T	T	4904033	3	4	234	1	0	0	0	0	1	0	0	0	11106	652	23	2	987	2	OR51T1	11	4904033	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	4103692	4904033	130102483	39	16589											
OR52H1	390067	broad.mit.edu	37	chr11	5565836	5565836	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agtataaccttatctctgatCtgcttggtcttcactccgta	6	11	4	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:5565836C>A	uc010qzh.1	-	1	918	c.918G>T	c.(916-918)CAG>CAT	p.Q306H	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TATCTCTGATCTGCTTGGTCT	0.403													A	5565836	A	A	5565836	3	1	234	1	0	0	0	0	1	0	0	0	11119	912	32	5	47	5	OR52H1	11	5565836	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	661803	5565836	129440680	40	16590											
TRIM22	10346	broad.mit.edu	37	chr11	5730417	5730417	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttctgcttttggtgtcttcGgctgccaatatttctcttcg	8	10	3	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:5730417G>A	uc001mbr.2	+	8	1313	c.1036G>A	c.(1036-1038)GGC>AGC	p.G346S	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Missense_Mutation_p.G342S|TRIM22_uc010qzm.1_Missense_Mutation_p.G174S|TRIM22_uc009yeu.2_Missense_Mutation_p.G157S|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	346	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TGGTGTCTTCGGCTGCCAATA	0.408													A	5730417	A	A	5730417	3	1	234	1	0	0	0	0	1	0	0	0	16493	1116	39	2	1062	2	TRIM22	11	5730417	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08	164581	5730417	129276099	41	16591											
MPEG1	219972	broad.mit.edu	37	chr11	58978683	58978683	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggggcactttttcagagaCggtgcccctaaatctctgga	11	12	2	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:58978683C>T	uc001nnu.3	-	1	1812	c.1656G>A	c.(1654-1656)CCG>CCA	p.P552P		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	552	Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				TTTTCAGAGACGGTGCCCCTA	0.567													T	58978683	T	T	58978683	2	4	234	1	0	0	0	0	0	0	0	1	9723	523	19	1		1	MPEG1	11	58978683	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	53248266	58978683	76027833	42	16592											
KRTAP5-9	3846	broad.mit.edu	37	chr11	71260048	71260048	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcagctgctgtaagccctgTtgctcctcctcgggtcgtgg	13	13	0	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:71260048T>C	uc001oqs.1	+	1	583	c.345T>C	c.(343-345)TGT>TGC	p.C115C		NM_005553	NP_005544	P26371	KRA59_HUMAN	keratin associated protein 5-9	115	8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament					0						GTAAGCCCTGTTGCTCCTCCT	0.622													C	71260048	C	C	71260048	2	2	234	1	0	0	0	0	0	0	0	1	8568	1731	60	4		4	KRTAP5-9	11	71260048	Silent	SNP	T	TCGA-32-2638-01A-01D-1495-08	12281365	71260048	63746468	43	16593											
NCAM1	4684	broad.mit.edu	37	chr11	113103495	113103496	+	Frame_Shift_Ins	INS	-	CATTGGGC	CATTGGGC													aactgtactgcagtgaaccgINScattgggcaggagtccttgg							TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:113103495_113103496insCATTGGGC	uc009yyq.1	+	13	1899_1900	c.1205_1206insCATTGGGC	c.(1204-1206)CGCfs	p.R402fs		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	494	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GCAGTGAACCGCATTGGGCAGG	0.51													CATTGGGC	113103496	CATTGGGC	CATTGGGC	113103495	7	5	234	1	0	1	1	0	0	0	0	0	10202	1087	38	0	1528	0	NCAM1	11	113103495	Frame_Shift_Ins	INS	-	TCGA-32-2638-01A-01D-1495-08	41843447	113103495	21903021	44	16594											
SIK3	23387	broad.mit.edu	37	chr11	116732043	116732043	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggactattactgggctgcCtgaagagatggttgttgggg	17	5	0	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:116732043C>T	uc001ppy.2	-	18	2090	c.2054G>A	c.(2053-2055)AGG>AAG	p.R685K	SIK3_uc001ppz.2_Missense_Mutation_p.R584K|SIK3_uc001pqa.2_Missense_Mutation_p.R685K|SIK3_uc001ppw.2_Missense_Mutation_p.R102K|SIK3_uc001ppx.2_Intron|SIK3_uc001pqb.2_5'UTR	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	685	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						ACTGGGCTGCCTGAAGAGATG	0.493											OREG0003492	type=REGULATORY REGION|Gene=BC035583|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	T	116732043	T	T	116732043	3	4	234	1	0	0	0	0	1	0	0	0	14319	681	24	3	1761	3	SIK3	11	116732043	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	3628548	116732043	18274473	45	16595											
TMPRSS4	56649	broad.mit.edu	37	chr11	117985628	117985628	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatcattggatggggctttaCgaagcagaatggaggtaagt	15	4	1	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:117985628C>T	uc010rxo.1	+	10	1286	c.995C>T	c.(994-996)ACG>ATG	p.T332M	TMPRSS4_uc010rxp.1_Missense_Mutation_p.T327M|TMPRSS4_uc010rxq.1_Missense_Mutation_p.T185M|TMPRSS4_uc010rxr.1_Missense_Mutation_p.T307M|TMPRSS4_uc010rxs.1_Missense_Mutation_p.T292M|TMPRSS4_uc009yzu.2_RNA|TMPRSS4_uc010rxt.1_Missense_Mutation_p.T307M	NM_019894	NP_063947	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4 isoform 1	332	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		TGGGGCTTTACGAAGCAGAAT	0.572													T	117985628	T	T	117985628	3	4	234	1	0	0	0	0	1	0	0	0	16246	536	19	1	1033	1	TMPRSS4	11	117985628	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	1253585	117985628	17020888	46	16596											
TECTA	7007	broad.mit.edu	37	chr11	121037459	121037459	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctcctttcagatcaacaaCaccaaagggaattgtggaaa	7	9	3	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr11:121037459C>T	uc010rzo.1	+	17	5556	c.5556C>T	c.(5554-5556)AAC>AAT	p.N1852N		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1852	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGATCAACAACACCAAAGGGA	0.498													T	121037459	T	T	121037459	2	4	234	1	0	0	0	0	0	0	0	1	15744	477	17	3		3	TECTA	11	121037459	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	3051831	121037459	13969057	47	16597											
CLEC12A	160364	broad.mit.edu	37	chr12	10132026	10132026	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aatatttctctacaactgatGagtaacatgaatatctccaa	4	8	2	3			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr12:10132026G>T	uc001qwr.3	+	3	470	c.282G>T	c.(280-282)ATG>ATT	p.M94I	CLEC12A_uc001qwq.2_Missense_Mutation_p.M104I|CLEC12A_uc001qws.3_Missense_Mutation_p.M61I|CLEC12A_uc001qwt.2_Missense_Mutation_p.M23I	NM_138337	NP_612210	Q5QGZ9	CL12A_HUMAN	myeloid inhibitory C-type lectin-like receptor	94	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity|sugar binding			skin(1)	1						TACAACTGATGAGTAACATGA	0.363													T	10132026	T	T	10132026	3	4	234	1	0	0	0	0	1	0	0	0	3497	1290	45	5	292	5	CLEC12A	12	10132026	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08		10132026	123719869	48	16598											
ITGB7	3695	broad.mit.edu	37	chr12	53590523	53590523	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgactggcagcgctccagcCgggtggggcaggggtggcgc	21	11	0	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr12:53590523C>T	uc009zmv.2	-	5	727	c.656G>A	c.(655-657)CGG>CAG	p.R219Q	ITGB7_uc001scc.2_Missense_Mutation_p.R219Q|ITGB7_uc010snz.1_RNA|ITGB7_uc010soa.1_3'UTR	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	219	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						GCGCTCCAGCCGGGTGGGGCA	0.617													T	53590523	T	T	53590523	3	4	234	1	0	0	0	0	1	0	0	0	7900	652	23	2	1784	2	ITGB7	12	53590523	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	43458497	53590523	80261372	49	16599											
ACACB	32	broad.mit.edu	37	chr12	109609642	109609642	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcggatcattacgtccccGtcccaggagggcccaataac	11	14	1	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr12:109609642G>A	uc001tob.2	+	5	1077	c.958G>A	c.(958-960)GTC>ATC	p.V320I	ACACB_uc001toc.2_Missense_Mutation_p.V320I	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	320	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TTACGTCCCCGTCCCAGGAGG	0.502													A	109609642	A	A	109609642	3	1	234	1	0	0	0	0	1	0	0	0	107	1145	40	1	972	1	ACACB	12	109609642	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08	56019119	109609642	24242253	50	16600											
XPO4	64328	broad.mit.edu	37	chr13	21362729	21362729	+	Frame_Shift_Del	DEL	G	-	-													cagataaatgtgattaatttGtagtactgattacaaagggt							TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr13:21362729delG	uc001unq.3	-	20	2979	c.2943delC	c.(2941-2943)TACfs	p.Y981fs		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	981					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		TGATTAATTTGTAGTACTGAT	0.299													-	21362729	-	-	21362729	7	5	234	1	0	1	0	1	0	0	0	0	17443	1372	48	0	528	0	XPO4	13	21362729	Frame_Shift_Del	DEL	G	TCGA-32-2638-01A-01D-1495-08		21362729	93807149	51	16601											
KCTD12	115207	broad.mit.edu	37	chr13	77459429	77459429	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accatgtggaagcccgactcGgacagcttgtcgaaggcctg	13	12	0	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr13:77459429G>A	uc010aeu.1	-	1	1112	c.855C>T	c.(853-855)TCC>TCT	p.S285S	KCTD12_uc001vka.1_Silent_p.S285S	NM_138444	NP_612453	Q96CX2	KCD12_HUMAN	potassium channel tetramerisation domain	285						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(1)	1		Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.0499)		AGCCCGACTCGGACAGCTTGT	0.637											OREG0022449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	77459429	A	A	77459429	2	1	234	1	0	0	0	0	0	0	0	1	8099	1103	39	2		2	KCTD12	13	77459429	Silent	SNP	G	TCGA-32-2638-01A-01D-1495-08	56096700	77459429	37710449	52	16602											
KCNH5	27133	broad.mit.edu	37	chr14	63447809	63447809	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccaggctatgttgttctgCtttgttttgaaggaaacatt	10	6	1	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr14:63447809C>T	uc001xfx.2	-	6	774	c.723G>A	c.(721-723)AAG>AAA	p.K241K	KCNH5_uc001xfy.2_Silent_p.K241K|KCNH5_uc001xfz.1_Silent_p.K183K|KCNH5_uc001xga.2_Silent_p.K183K	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	241	Extracellular (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TGTTGTTCTGCTTTGTTTTGA	0.398													T	63447809	T	T	63447809	2	4	234	1	0	0	0	0	0	0	0	1	8035	796	28	3		3	KCNH5	14	63447809	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08		63447809	43901731	53	16603											
KIAA1409	57578	broad.mit.edu	37	chr14	94052956	94052956	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcacagcagtaaagaatgatAccgaaagaaaattttgctac	7	7	1	3			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr14:94052956A>G	uc001ybv.1	+	18	2370	c.2287A>G	c.(2287-2289)ACC>GCC	p.T763A	KIAA1409_uc001ybs.1_Missense_Mutation_p.T763A	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	940						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AAAGAATGATACCGAAAGAAA	0.338													G	94052956	G	G	94052956	3	3	234	1	0	0	0	0	1	0	0	0	8230	391	14	4	2357	4	KIAA1409	14	94052956	Missense_Mutation	SNP	A	TCGA-32-2638-01A-01D-1495-08	30605147	94052956	13296584	54	16604											
SERPINA9	327657	broad.mit.edu	37	chr14	94933658	94933658	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatgcacagtgacctgctcGcccaccaggaatgggaagtt	11	12	0	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr14:94933658G>A	uc001ydf.2	-	3	905	c.744C>T	c.(742-744)GGC>GGT	p.G248G	SERPINA9_uc001yde.2_Silent_p.G148G|SERPINA9_uc010avc.2_Silent_p.G99G|SERPINA9_uc001ydg.2_Silent_p.G212G|SERPINA9_uc001ydh.1_Silent_p.G248G|SERPINA9_uc001ydi.1_Silent_p.G212G	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	230					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		TGACCTGCTCGCCCACCAGGA	0.473													A	94933658	A	A	94933658	2	1	234	1	0	0	0	0	0	0	0	1	14095	1074	38	1		1	SERPINA9	14	94933658	Silent	SNP	G	TCGA-32-2638-01A-01D-1495-08	880702	94933658	12415882	55	16605											
TMCO5A	145942	broad.mit.edu	37	chr15	38239874	38239874	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cagggtactcctacccaaaaGacagcaagattattcagtaa	7	10	1	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr15:38239874G>C	uc001zjw.2	+	10	748	c.645G>C	c.(643-645)AAG>AAC	p.K215N	TMCO5A_uc001zjv.1_Missense_Mutation_p.K215N	NM_152453	NP_689666	Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	215						integral to membrane				central_nervous_system(1)	1						CTACCCAAAAGACAGCAAGAT	0.318													C	38239874	C	C	38239874	3	2	234	1	0	0	0	0	1	0	0	0	15996	933	33	5	679	5	TMCO5A	15	38239874	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08		38239874	64291518	56	16606											
SRRM2	23524	broad.mit.edu	37	chr16	2812739	2812739	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gaaaaacaaatccagaacatCtcaaagaagaagcaggtcca	7	9	1	3			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr16:2812739C>T	uc002crk.2	+	11	2759	c.2210C>T	c.(2209-2211)TCT>TTT	p.S737F	SRRM2_uc002crj.1_Missense_Mutation_p.S641F|SRRM2_uc002crl.1_Missense_Mutation_p.S737F|SRRM2_uc010bsu.1_Missense_Mutation_p.S641F	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	737	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCCAGAACATCTCAAAGAAGA	0.448													T	2812739	T	T	2812739	3	4	234	1	0	0	0	0	1	0	0	0	15168	913	32	3	2248	3	SRRM2	16	2812739	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08		2812739	87542014	57	16607											
VPS53	55275	broad.mit.edu	37	chr17	440383	440383	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggtgacgtaggggctctGgtcaccaacgtgctccacgt	14	11	2	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr17:440383G>A	uc002frn.2	-	18	2047	c.1900C>T	c.(1900-1902)CAG>TAG	p.Q634*	VPS53_uc002frk.2_Nonsense_Mutation_p.Q153*|VPS53_uc010cjo.1_Nonsense_Mutation_p.Q634*|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Nonsense_Mutation_p.Q605*|VPS53_uc002fro.2_Nonsense_Mutation_p.Q436*|VPS53_uc010cjp.1_Nonsense_Mutation_p.Q357*	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	634					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		TAGGGGCTCTGGTCACCAACG	0.547													A	440383	A	A	440383	4	1	234	1	0	0	0	0	0	1	0	0	17212	1357	47	3	633	3	VPS53	17	440383	Nonsense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08		440383	80754827	58	16608											
GSDMB	55876	broad.mit.edu	37	chr17	38062400	38062400	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgccgaatatcctccttgccGaggcacttagcgagggagtt	12	11	0	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr17:38062400G>A	uc010cwj.2	-	7	857	c.852C>T	c.(850-852)CTC>CTT	p.L284L	GSDMB_uc010cwi.2_Silent_p.L31L|GSDMB_uc010cwk.2_RNA|GSDMB_uc010cwl.2_RNA|GSDMB_uc010cwm.2_RNA|GSDMB_uc002htg.2_Silent_p.L262L|GSDMB_uc002hth.2_Silent_p.L271L|GSDMB_uc010wem.1_Silent_p.L275L	NM_001042471	NP_001035936	Q8TAX9	GSDMB_HUMAN	gasdermin B isoform 1	279						cytoplasm				breast(1)|pancreas(1)	2						CCTCCTTGCCGAGGCACTTAG	0.522													A	38062400	A	A	38062400	2	1	234	1	0	0	0	0	0	0	0	1	6817	1045	37	2		2	GSDMB	17	38062400	Silent	SNP	G	TCGA-32-2638-01A-01D-1495-08	37622017	38062400	43132810	59	16609											
ITGA3	3675	broad.mit.edu	37	chr17	48156217	48156217	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggctacaaagcttctttgGggggacagtgatgggtgagt	16	7	1	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr17:48156217G>A	uc010dbl.2	+	19	2791	c.2327G>A	c.(2326-2328)GGG>GAG	p.G776E	ITGA3_uc010dbm.2_Missense_Mutation_p.G776E	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	776	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						AGCTTCTTTGGGGGGACAGTG	0.582													A	48156217	A	A	48156217	3	1	234	1	0	0	0	0	1	0	0	0	7877	1232	43	3	2401	3	ITGA3	17	48156217	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08	10093817	48156217	33038993	60	16610											
ANKRD40	91369	broad.mit.edu	37	chr17	48776813	48776813	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaatggctggaatgctggcGctggtcctgcatacgtccca	12	11	0	0	rs148279576		TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr17:48776813G>A	uc002iso.2	-	3	980	c.725C>T	c.(724-726)GCG>GTG	p.A242V		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	242	Pro-rich.										0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			GAATGCTGGCGCTGGTCCTGC	0.522													A	48776813	A	A	48776813	3	1	234	1	0	0	0	0	1	0	0	0	669	1087	38	1	393	1	ANKRD40	17	48776813	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08	620596	48776813	32418397	61	16611											
COIL	8161	broad.mit.edu	37	chr17	55027963	55027963	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttttggagaactacatctctGattggcccagtctttcactg	8	10	3	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr17:55027963G>T	uc002iuu.2	-	2	671	c.640C>A	c.(640-642)CAG>AAG	p.Q214K		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	214						Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					CTACATCTCTGATTGGCCCAG	0.403													T	55027963	T	T	55027963	3	4	234	1	0	0	0	0	1	0	0	0	3665	1299	45	5	1114	5	COIL	17	55027963	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08	6251150	55027963	26167247	62	16612											
ABCA9	10350	broad.mit.edu	37	chr17	66981088	66981088	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatccagaagcaccactgaCgggttccccaggatgctcag	10	14	2	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr17:66981088C>T	uc002jhu.2	-	34	4460	c.4317G>A	c.(4315-4317)CCG>CCA	p.P1439P	ABCA9_uc010dez.2_Silent_p.P1401P	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1439	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					GCACCACTGACGGGTTCCCCA	0.587													T	66981088	T	T	66981088	2	4	234	1	0	0	0	0	0	0	0	1	39	523	19	1		1	ABCA9	17	66981088	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	11953125	66981088	14214122	63	16613											
SETBP1	26040	broad.mit.edu	37	chr18	42529847	42529847	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccactccacccacccttaggCttacgagaggccccagaaac	7	18	0	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr18:42529847C>G	uc010dni.2	+	4	838	c.542C>G	c.(541-543)GCT>GGT	p.A181G		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	181						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CACCCTTAGGCTTACGAGAGG	0.398									Schinzel-Giedion_syndrome				G	42529847	G	G	42529847	3	3	234	1	0	0	0	0	1	0	0	0	14129	811	28	5	745	5	SETBP1	18	42529847	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08		42529847	35547401	64	16614											
SLC14A1	6563	broad.mit.edu	37	chr18	43310353	43310353	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	taggggtgaaaaccaggtttCgccatgtcaagggagaaggt	15	6	1	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr18:43310353C>T	uc010xcn.1	+	4	387	c.68C>T	c.(67-69)TCG>TTG	p.S23L	SLC14A1_uc010dnk.2_Missense_Mutation_p.S79L|SLC14A1_uc002lbf.3_Missense_Mutation_p.S23L|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Intron|SLC14A1_uc002lbh.3_Intron|SLC14A1_uc002lbi.3_Intron|SLC14A1_uc002lbj.3_Missense_Mutation_p.S79L|SLC14A1_uc002lbk.3_Missense_Mutation_p.S23L	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	23						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						AACCAGGTTTCGCCATGTCAA	0.507													T	43310353	T	T	43310353	3	4	234	1	0	0	0	0	1	0	0	0	14396	893	31	2	242	2	SLC14A1	18	43310353	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	780506	43310353	34766895	65	16615											
SF3A2	8175	broad.mit.edu	37	chr19	2248259	2248260	+	Frame_Shift_Ins	INS	-	G	G													gtccatcctcccccatcagcINSgggggttcacccccaggccc							TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr19:2248259_2248260insG	uc002lvg.2	+	9	1231_1232	c.1109_1110insG	c.(1108-1110)GCGfs	p.A370fs	AMH_uc002lvh.2_5'Flank|hsa-mir-4321|MI0015852_5'Flank	NM_007165	NP_009096	Q15428	SF3A2_HUMAN	splicing factor 3a, subunit 2	370	Pro-rich.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex	nucleic acid binding|zinc ion binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCCATCAGCGGGGGTTCACC	0.748													G	2248260	G	G	2248259	7	5	234	1	0	1	1	0	0	0	0	0	14147	768	27	0	1139	0	SF3A2	19	2248259	Frame_Shift_Ins	INS	-	TCGA-32-2638-01A-01D-1495-08		2248259	56880724	66	16616											
LRRC8E	80131	broad.mit.edu	37	chr19	7965735	7965735	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcaagaaggcggggctcctGgtggaagacacgctttacca	13	11	1	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr19:7965735G>T	uc002mir.2	+	3	2429	c.2328G>T	c.(2326-2328)CTG>CTT	p.L776L		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	776						integral to membrane				lung(1)|pancreas(1)	2						CGGGGCTCCTGGTGGAAGACA	0.597													T	7965735	T	T	7965735	2	4	234	1	0	0	0	0	0	0	0	1	9025	1335	47	5		5	LRRC8E	19	7965735	Silent	SNP	G	TCGA-32-2638-01A-01D-1495-08	5717476	7965735	51163248	67	16617											
MUC16	94025	broad.mit.edu	37	chr19	9072143	9072143	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaagtggccagtatcttatcTgaggtgctgctgaaatttgg	13	6	2	2			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr19:9072143T>A	uc002mkp.2	-	3	15507	c.15303A>T	c.(15301-15303)TCA>TCT	p.S5101S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5103	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTATCTTATCTGAGGTGCTGC	0.423													A	9072143	A	A	9072143	2	1	234	1	0	0	0	0	0	0	0	1	9973	1567	55	5		5	MUC16	19	9072143	Silent	SNP	T	TCGA-32-2638-01A-01D-1495-08	1106408	9072143	50056840	68	16618											
CRKL	1399	broad.mit.edu	37	chr22	21272527	21272527	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccaccctcatcgagcctgCgcccaggtacgcgagagccc	10	19	1	1			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr22:21272527C>T	uc002ztf.2	+	1	814	c.305C>T	c.(304-306)GCG>GTG	p.A102V	CRKL_uc002ztg.1_RNA	NM_005207	NP_005198	P46109	CRKL_HUMAN	v-crk sarcoma virus CT10 oncogene homolog	102	SH2.				JNK cascade|Ras protein signal transduction	cytosol	protein tyrosine kinase activity|SH3/SH2 adaptor activity|signal transducer activity				0	all_cancers(11;1.16e-25)|all_epithelial(7;3.37e-24)|Lung NSC(8;7.25e-16)|all_lung(8;1.37e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.176)			ATCGAGCCTGCGCCCAGGTAC	0.607													T	21272527	T	T	21272527	3	4	234	1	0	0	0	0	1	0	0	0	3885	768	27	1	307	1	CRKL	22	21272527	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08		21272527	30032039	69	16619											
MTMR3	8897	broad.mit.edu	37	chr22	30413988	30413988	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acctgccctgcccatccccaAccacccctgtggacgacagc	7	21	0	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr22:30413988A>G	uc003agv.3	+	16	2075	c.1747A>G	c.(1747-1749)ACC>GCC	p.T583A	MTMR3_uc003agu.3_Missense_Mutation_p.T583A|MTMR3_uc003agw.3_Missense_Mutation_p.T583A	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	583					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			CCCATCCCCAACCACCCCTGT	0.632													G	30413988	G	G	30413988	3	3	234	1	0	0	0	0	1	0	0	0	9945	43	2	4	1801	4	MTMR3	22	30413988	Missense_Mutation	SNP	A	TCGA-32-2638-01A-01D-1495-08	9141461	30413988	20890578	70	16620											
SLC5A4	6527	broad.mit.edu	37	chr22	32626981	32626981	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatcagttccagcaccatcGtggggtatgcgtagttggtg	14	9	1	0	rs150200210		TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr22:32626981G>A	uc003ami.2	-	10	1105	c.1103C>T	c.(1102-1104)ACG>ATG	p.T368M		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	368	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CAGCACCATCGTGGGGTATGC	0.537													A	32626981	A	A	32626981	3	1	234	1	0	0	0	0	1	0	0	0	14667	1145	40	1	900	1	SLC5A4	22	32626981	Missense_Mutation	SNP	G	TCGA-32-2638-01A-01D-1495-08	2212993	32626981	18677585	71	16621											
MKL1	57591	broad.mit.edu	37	chr22	40814904	40814904	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctctagctccgcccgccccCcagggctcaggcaacaggac	10	20	2	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr22:40814904C>T	uc003ayv.1	-	9	1745	c.1538G>A	c.(1537-1539)GGG>GAG	p.G513E	MKL1_uc003ayw.1_Missense_Mutation_p.G513E|MKL1_uc010gye.1_Missense_Mutation_p.G513E|MKL1_uc010gyf.1_Missense_Mutation_p.G463E	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	513					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CGCCCGCCCCCCAGGGCTCAG	0.672			T	RBM15	acute megakaryocytic leukemia								T	40814904	T	T	40814904	3	4	234	1	0	0	0	0	1	0	0	0	9601	623	22	3	1273	3	MKL1	22	40814904	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	8187923	40814904	10489662	72	16622											
TEF	7008	broad.mit.edu	37	chr22	41790269	41790269	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gctgaggaggacctgaagccCcagcctatgatcaaaaaggc	12	11	1	3			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chr22:41790269C>A	uc003azy.2	+	3	731	c.645C>A	c.(643-645)CCC>CCA	p.P215P	TEF_uc003azx.2_Silent_p.P185P|TEF_uc011apa.1_Silent_p.P220P	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	215	Pro-rich (proline/acidic region (PAR)).				rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACCTGAAGCCCCAGCCTATGA	0.547													A	41790269	A	A	41790269	2	1	234	1	0	0	0	0	0	0	0	1	15747	610	22	5		5	TEF	22	41790269	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08	975365	41790269	9514297	73	16623											
OTUD6A	139562	broad.mit.edu	37	chrX	69283226	69283226	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ggcgccgccgggggcgtgctCccgcgtctcctgtaggcccc	16	18	1	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chrX:69283226C>G	uc004dxu.1	+	1	886	c.852C>G	c.(850-852)CTC>CTG	p.L284L		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	284										lung(1)|skin(1)	2						GGGGCGTGCTCCCGCGTCTCC	0.607													G	69283226	G	G	69283226	2	3	234	1	0	0	0	0	0	0	0	1	11316	842	30	5		5	OTUD6A	23	69283226	Silent	SNP	C	TCGA-32-2638-01A-01D-1495-08		69283226	85987334	74	16624											
GLUD2	2747	broad.mit.edu	37	chrX	120181603	120181603	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccgctgccctgggctccgCggccaaccactcggccgcgt	13	20	0	0			TCGA-32-2638-01A-01D-1495-08	TCGA-32-2638-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	1e103221-ab46-4a5c-9b96-5e34f0d49fc2	1f0b3a10-8f1e-432c-9c39-cdcb8855a4c2	g.chrX:120181603C>T	uc004eto.2	+	1	142	c.65C>T	c.(64-66)GCG>GTG	p.A22V		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	22					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	CTGGGCTCCGCGGCCAACCAC	0.786													T	120181603	T	T	120181603	3	4	234	1	0	0	0	0	1	0	0	0	6477	768	27	1	67	1	GLUD2	23	120181603	Missense_Mutation	SNP	C	TCGA-32-2638-01A-01D-1495-08	50898377	120181603	35088957	75	16625											
MFN2	9927	broad.mit.edu	37	chr1	12052619	12052619	+	Nonsense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tccccacctccagacacgtaCaggaatgcagaactggaccc	8	16	0	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr1:12052619C>G	uc001atn.3	+	4	636	c.183C>G	c.(181-183)TAC>TAG	p.Y61*	MFN2_uc009vni.2_Nonsense_Mutation_p.Y61*	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	61	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CAGACACGTACAGGAATGCAG	0.562													G	12052619	G	G	12052619	4	3	235	1	0	0	0	0	0	1	0	0	9524	489	17	5	189	5	MFN2	1	12052619	Nonsense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08		12052619	237198002	1	16626											
JAK1	3716	broad.mit.edu	37	chr1	65313353	65313353	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctcgtgcctctcccaaggtgCtcgccctgagggaagaagca	12	14	1	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr1:65313353C>A	uc001dbu.1	-	13	2010	c.1761G>T	c.(1759-1761)GAG>GAT	p.E587D	JAK1_uc009wam.1_Missense_Mutation_p.E575D|JAK1_uc009wal.1_5'Flank	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	587	Protein kinase 1.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TCCCAAGGTGCTCGCCCTGAG	0.507			Mis		ALL								A	65313353	A	A	65313353	3	1	235	1	0	0	0	0	1	0	0	0	7937	796	28	5	1755	5	JAK1	1	65313353	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	53260734	65313353	183937268	2	16627											
EPHX4	253152	broad.mit.edu	37	chr1	92515977	92515977	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttctcaataaatgatttcaaGgtaagccaaacaaatcaaac	4	8	3	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr1:92515977G>C	uc001don.2	+	5	812	c.708G>C	c.(706-708)AAG>AAC	p.K236N		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	236						integral to membrane	hydrolase activity			central_nervous_system(1)	1						ATGATTTCAAGGTAAGCCAAA	0.259													C	92515977	C	C	92515977	3	2	235	1	0	0	0	0	1	0	0	0	5182	1014	35	5	726	5	EPHX4	1	92515977	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	27202624	92515977	156734644	3	16628											
EXTL2	2135	broad.mit.edu	37	chr1	101339636	101339636	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcagagcgtgctcagctcgAtgccacattccagaatagcc	10	13	1	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr1:101339636A>G	uc001dtk.1	-	5	1192	c.855T>C	c.(853-855)CAT>CAC	p.H285H	EXTL2_uc001dtl.1_Silent_p.H285H|EXTL2_uc010ouk.1_Silent_p.H272H|EXTL2_uc001dtm.1_Silent_p.H284H	NM_001439	NP_001430	Q9UBQ6	EXTL2_HUMAN	exostoses-like 2	285	Lumenal (Potential).				N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		GCTCAGCTCGATGCCACATTC	0.398													G	101339636	G	G	101339636	2	3	235	1	0	0	0	0	0	0	0	1	5326	330	12	4		4	EXTL2	1	101339636	Silent	SNP	A	TCGA-32-4208-01A-01D-1353-08	8823659	101339636	147910985	4	16629											
NUP210L	91181	broad.mit.edu	37	chr1	154125256	154125256	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgctgaggcgtatcggttgcGtagattcagcaatgagtaca	13	7	1	3	rs150389273	by1000genomes	TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr1:154125256G>C	uc001fdw.2	-	2	368	c.296C>G	c.(295-297)ACG>AGG	p.T99R	NUP210L_uc010peh.1_Missense_Mutation_p.T99R	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	99						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TATCGGTTGCGTAGATTCAGC	0.423													C	154125256	C	C	154125256	3	2	235	1	0	0	0	0	1	0	0	0	10761	1145	40	5	5526	5	NUP210L	1	154125256	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	52785620	154125256	95125365	5	16630											
HMCN1	83872	broad.mit.edu	37	chr1	185878606	185878606	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcactgtgtctttgagtggGccttctccaatgattgaaat	10	8	3	3			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr1:185878606G>A	uc001grq.1	+	5	988	c.759G>A	c.(757-759)GGG>GGA	p.G253G		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	253					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CTTTGAGTGGGCCTTCTCCAA	0.363													A	185878606	A	A	185878606	2	1	235	1	0	0	0	0	0	0	0	1	7220	1190	42	3		3	HMCN1	1	185878606	Silent	SNP	G	TCGA-32-4208-01A-01D-1353-08	31753350	185878606	63372015	6	16631											
CACNA1S	779	broad.mit.edu	37	chr1	201029914	201029914	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aatgtagcacctcagtgggcGggccttcagggcatactgta	13	10	2	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr1:201029914G>T	uc001gvv.2	-	26	3513	c.3286C>A	c.(3286-3288)CGC>AGC	p.R1096S		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1096	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTCAGTGGGCGGGCCTTCAGG	0.532													T	201029914	T	T	201029914	3	4	235	1	0	0	0	0	1	0	0	0	2547	1116	39	5	2411	5	CACNA1S	1	201029914	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	15151308	201029914	48220707	7	16632											
EPRS	2058	broad.mit.edu	37	chr1	220146600	220146600	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cttgtgaaaagggtgacctgGatgtcttccaaaatagcttg	11	7	1	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr1:220146600G>C	uc001hly.1	-	29	4494	c.4224C>G	c.(4222-4224)ATC>ATG	p.I1408M		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1408	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	GGGTGACCTGGATGTCTTCCA	0.423													C	220146600	C	C	220146600	3	2	235	1	0	0	0	0	1	0	0	0	5191	1164	41	5	330	5	EPRS	1	220146600	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	19116686	220146600	29104021	8	16633											
IFT172	26160	broad.mit.edu	37	chr2	27688614	27688614	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttattggccagcctctcaccGgatgtagttgccatcatcaa	8	12	3	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr2:27688614G>A	uc002rku.2	-	17	1879	c.1828C>T	c.(1828-1830)CGG>TGG	p.R610W		NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	610	TPR 1.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					GCCTCTCACCGGATGTAGTTG	0.537													A	27688614	A	A	27688614	3	1	235	1	0	0	0	0	1	0	0	0	7557	1130	39	2	3549	2	IFT172	2	27688614	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08		27688614	215510759	9	16634											
GCC2	9648	broad.mit.edu	37	chr2	109103075	109103075	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cataccagcagagagtgacaGcactacaggaagagtgccgt	12	10	0	3			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr2:109103075G>A	uc002tec.2	+	16	4055	c.3901G>A	c.(3901-3903)GCA>ACA	p.A1301T	GCC2_uc002ted.2_Missense_Mutation_p.A1200T	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1301	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						GAGAGTGACAGCACTACAGGA	0.512													A	109103075	A	A	109103075	3	1	235	1	0	0	0	0	1	0	0	0	6286	971	34	3	3963	3	GCC2	2	109103075	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	81414461	109103075	134096298	10	16635											
LRP2	4036	broad.mit.edu	37	chr2	170026272	170026272	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccatcgcatttcagttcacTgtgtacacaatgtccacttg	6	12	2	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr2:170026272T>C	uc002ues.2	-	60	11650	c.11437A>G	c.(11437-11439)AGT>GGT	p.S3813G		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3813	Extracellular (Potential).|LDL-receptor class A 33.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTCAGTTCACTGTGTACACAA	0.438													C	170026272	C	C	170026272	3	2	235	1	0	0	0	0	1	0	0	0	8956	1580	55	4	2610	4	LRP2	2	170026272	Missense_Mutation	SNP	T	TCGA-32-4208-01A-01D-1353-08	60923197	170026272	73173101	11	16636											
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								T	209113112	T	T	209113112	3	4	235	1	0	0	0	0	1	0	0	0	7494	536	19	1	877	1	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	39086840	209113112	34086261	12	16637											
RHBDD1	84236	broad.mit.edu	37	chr2	227729644	227729644	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cccttcaccatgctgatgatTggcatttgtatttcaatatg	7	9	2	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr2:227729644T>C	uc002voi.2	+	2	356	c.235T>C	c.(235-237)TGG>CGG	p.W79R	RHBDD1_uc010fxc.2_Missense_Mutation_p.W79R	NM_032276	NP_115652	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	79						integral to membrane	serine-type endopeptidase activity			ovary(1)	1		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		TGCTGATGATTGGCATTTGTA	0.438													C	227729644	C	C	227729644	3	2	235	1	0	0	0	0	1	0	0	0	13316	1812	63	4	237	4	RHBDD1	2	227729644	Missense_Mutation	SNP	T	TCGA-32-4208-01A-01D-1353-08	18616532	227729644	15469729	13	16638											
BOK	666	broad.mit.edu	37	chr2	242509549	242509549	+	Frame_Shift_Del	DEL	G	-	-													tctccctgcaggcatcacgtGgggcaaggtggtgtccctgt							TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr2:242509549delG	uc002wbq.2	+	4	605	c.359delG	c.(358-360)TGGfs	p.W120fs	BOK_uc002wbr.2_5'Flank	NM_032515	NP_115904	Q9UMX3	BOK_HUMAN	BCL2-related ovarian killer	120	BH1.				activation of caspase activity|cell proliferation|signal transduction by p53 class mediator resulting in induction of apoptosis	mitochondrial membrane|nucleus				ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.04e-33)|all cancers(36;7.87e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.52e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.64e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0835)		GGCATCACGTGGGGCAAGGTG	0.657													-	242509549	-	-	242509549	7	5	235	1	0	1	0	1	0	0	0	0	1484	1357	47	0	369	0	BOK	2	242509549	Frame_Shift_Del	DEL	G	TCGA-32-4208-01A-01D-1353-08	14779905	242509549	689824	14	16639											
TATDN2	9797	broad.mit.edu	37	chr3	10312062	10312064	+	In_Frame_Del	DEL	GCA	-	-													ttctagctacccctccacagGcagcagcagcaacgatgcag							TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr3:10312062_10312064delGCA	uc003bvg.2	+	4	1777_1779	c.1196_1198delGCA	c.(1195-1200)GGCAGC>GGC	p.S402del	TATDN2_uc003bvf.2_In_Frame_Del_p.S402del|TATDN2_uc011atr.1_In_Frame_Del_p.S402del|TATDN2_uc011ats.1_RNA|TATDN2_uc011att.1_RNA	NM_014760	NP_055575	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	402						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			pancreas(2)	2						CCCTCCACAGGCAGCAGCAGCAA	0.552													-	10312064	-	-	10312062	7	5	235	1	0	1	0	1	0	0	0	0	15589	1203	42	0	1206	0	TATDN2	3	10312062	In_Frame_Del	DEL	GCA	TCGA-32-4208-01A-01D-1353-08		10312062	187710368	15	16640											
DOCK3	1795	broad.mit.edu	37	chr3	51387773	51387773	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agcagcaacgcctggagcctGagttctttcgggtcggcttc	13	12	1	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr3:51387773G>C	uc011bds.1	+	40	4080	c.4057G>C	c.(4057-4059)GAG>CAG	p.E1353Q		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1353	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CCTGGAGCCTGAGTTCTTTCG	0.448													C	51387773	C	C	51387773	3	2	235	1	0	0	0	0	1	0	0	0	4688	1291	45	5	4215	5	DOCK3	3	51387773	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	41075711	51387773	146634657	16	16641											
TNFSF10	8743	broad.mit.edu	37	chr3	172232698	172232698	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttgacttgccagcaggggcTgttcatactctcttcgtcat	9	12	3	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr3:172232698T>C	uc003fid.2	-	2	318	c.223A>G	c.(223-225)AGC>GGC	p.S75G	TNFSF10_uc003fie.2_Missense_Mutation_p.S75G	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	75	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CAGCAGGGGCTGTTCATACTC	0.498													C	172232698	C	C	172232698	3	2	235	1	0	0	0	0	1	0	0	0	16298	1580	55	4	638	4	TNFSF10	3	172232698	Missense_Mutation	SNP	T	TCGA-32-4208-01A-01D-1353-08	120844925	172232698	25789732	17	16642											
SPATA16	83893	broad.mit.edu	37	chr3	172835032	172835032	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aggcagaaagctgaaattatGtacactcaaagggtctacta	9	7	2	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr3:172835032G>C	uc003fin.3	-	2	648	c.490C>G	c.(490-492)CAT>GAT	p.H164D		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	164					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CTGAAATTATGTACACTCAAA	0.448													C	172835032	C	C	172835032	3	2	235	1	0	0	0	0	1	0	0	0	15000	1377	48	5	1259	5	SPATA16	3	172835032	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	602334	172835032	25187398	18	16643											
GABRA2	2555	broad.mit.edu	37	chr4	46252347	46252347	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggactgacccctaatacaGgttctctgtttaaatatgta	7	8	1	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr4:46252347G>A	uc003gxc.3	-	9	2007	c.1334C>T	c.(1333-1335)CCT>CTT	p.P445L	GABRA2_uc010igc.2_Missense_Mutation_p.P445L|GABRA2_uc011bzc.1_Missense_Mutation_p.P450L	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	445					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CCCTAATACAGGTTCTCTGTT	0.338													A	46252347	A	A	46252347	3	1	235	1	0	0	0	0	1	0	0	0	6161	1000	35	3	25	3	GABRA2	4	46252347	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08		46252347	144901929	19	16644											
FAM175A	84142	broad.mit.edu	37	chr4	84388619	84388641	+	Frame_Shift_Del	DEL	TTGTAATGAAGCATACATTTCAT	-	-													taacttacctttaattcctcTtgtaatgaagcatacatttc							TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr4:84388619_84388641delTTGTAATGAAGCATACATTTCAT	uc003hou.2	-	7	712_734	c.647_669delATGAAATGTATGCTTCATTACAA	c.(646-669)AATGAAATGTATGCTTCATTACAAfs	p.N216fs	MRPS18C_uc011ccu.1_Intron|FAM175A_uc003hot.2_Frame_Shift_Del_p.N44fs|FAM175A_uc003hov.2_Frame_Shift_Del_p.N107fs	NM_139076	NP_620775	Q6UWZ7	F175A_HUMAN	coiled-coil domain containing 98	216_223	Potential.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1						TTAATTCCTCTTGTAATGAAGCATACATTTCATTTATCTTATG	0.309													-	84388641	-	-	84388619	7	5	235	1	0	1	0	1	0	0	0	0	5497	1606	56	0	572	0	FAM175A	4	84388619	Frame_Shift_Del	DEL	TTGTAATGAAGCATACATTTCAT	TCGA-32-4208-01A-01D-1353-08	38136272	84388619	106765657	20	16645											
SEC24B	10427	broad.mit.edu	37	chr4	110442579	110442579	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatctttgttttctcagcttAtaaaagacttactgaatgca	6	7	2	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr4:110442579A>G	uc003hzk.2	+	14	2360	c.2305A>G	c.(2305-2307)ATA>GTA	p.I769V	SEC24B_uc003hzl.2_Missense_Mutation_p.I734V|SEC24B_uc011cfp.1_Missense_Mutation_p.I799V|SEC24B_uc011cfq.1_Missense_Mutation_p.I768V|SEC24B_uc011cfr.1_Missense_Mutation_p.I733V	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	769					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TTCTCAGCTTATAAAAGACTT	0.343													G	110442579	G	G	110442579	3	3	235	1	0	0	0	0	1	0	0	0	13995	449	16	4	2359	4	SEC24B	4	110442579	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08	26053960	110442579	80711697	21	16646											
MYOZ2	51778	broad.mit.edu	37	chr4	120085521	120085521	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tcaagcctgaaggaaaggcaGaactgcctgattacaggagc	12	9	1	3			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr4:120085521G>C	uc003icp.3	+	5	745	c.532G>C	c.(532-534)GAA>CAA	p.E178Q		NM_016599	NP_057683	Q9NPC6	MYOZ2_HUMAN	myozenin 2	178							protein phosphatase 2B binding				0						AGGAAAGGCAGAACTGCCTGA	0.418													C	120085521	C	C	120085521	3	2	235	1	0	0	0	0	1	0	0	0	10096	943	33	5	546	5	MYOZ2	4	120085521	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	9642942	120085521	71068755	22	16647											
PCDHA4	56144	broad.mit.edu	37	chr5	140189035	140189035	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtcatactcgcagcagaggAggccgagggtgtgctctggt	17	9	2	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr5:140189035A>G	uc003lhi.2	+	1	2364	c.2263A>G	c.(2263-2265)AGG>GGG	p.R755G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.R755G|PCDHA4_uc011daa.1_Missense_Mutation_p.R755G	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	755	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCAGAGGAGGCCGAGGGT	0.662													G	140189035	G	G	140189035	3	3	235	1	0	0	0	0	1	0	0	0	11526	295	11	4	2265	4	PCDHA4	5	140189035	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08		140189035	40726225	23	16648											
CLK4	57396	broad.mit.edu	37	chr5	178040532	178040532	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtggtcaatttgaaatggCagaaagctgttttctttaat	9	4	2	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr5:178040532C>T	uc003mjf.1	-	7	876	c.768G>A	c.(766-768)CTG>CTA	p.L256L	CLK4_uc003mjg.1_Silent_p.L220L|CLK4_uc010jku.1_Silent_p.L76L|CLK4_uc003mjh.1_Silent_p.L76L|CLK4_uc010jkv.1_RNA|CLK4_uc011dgg.1_Silent_p.L256L|CLK4_uc011dgh.1_Silent_p.L76L	NM_020666	NP_065717	Q9HAZ1	CLK4_HUMAN	CDC-like kinase 4	256	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(1)	1	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)		TTTGAAATGGCAGAAAGCTGT	0.328													T	178040532	T	T	178040532	2	4	235	1	0	0	0	0	0	0	0	1	3539	697	25	3		3	CLK4	5	178040532	Silent	SNP	C	TCGA-32-4208-01A-01D-1353-08	37851497	178040532	2874728	24	16649											
KIF13A	63971	broad.mit.edu	37	chr6	17831467	17831467	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcaagttgtcgttgtctttcCtgtgcacaaaaacagacaaa	7	9	2	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr6:17831467C>A	uc003ncg.3	-	13	1372	c.1267_splice	c.e13-1	p.E423_splice	KIF13A_uc003ncf.2_Splice_Site_p.E423_splice|KIF13A_uc003nch.3_Splice_Site_p.E423_splice|KIF13A_uc003nci.3_Splice_Site_p.E423_splice|KIF13A_uc003ncj.2_Splice_Site_p.E99_splice	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a						cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GTTGTCTTTCCTGTGCACAAA	0.438													A	17831467	A	A	17831467	5	1	235	1	0	0	0	0	0	0	1	0	8274	695	24	5	4284	5	KIF13A	6	17831467	Splice_Site	SNP	C	TCGA-32-4208-01A-01D-1353-08		17831467	153283600	25	16650											
BTNL2	56244	broad.mit.edu	37	chr6	32370963	32370963	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctccactctccccaggtcccTccatgtggatgctaggggca	10	16	1	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr6:32370963T>C	uc003obg.1	-	3	458	c.458A>G	c.(457-459)GAG>GGG	p.E153G	BTNL2_uc010jty.1_Intron|BTNL2_uc010jtz.1_Intron|BTNL2_uc010jua.1_Intron	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	153	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						CCCAGGTCCCTCCATGTGGAT	0.607													C	32370963	C	C	32370963	3	2	235	1	0	0	0	0	1	0	0	0	1565	1551	54	4	925	4	BTNL2	6	32370963	Missense_Mutation	SNP	T	TCGA-32-4208-01A-01D-1353-08	14539496	32370963	138744104	26	16651											
DEF6	50619	broad.mit.edu	37	chr6	35280172	35280172	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcccaggaggcccaggtgGcccagaccaccggggggctc	17	15	0	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr6:35280172G>A	uc003okk.2	+	4	556	c.517G>A	c.(517-519)GCC>ACC	p.A173T	DEF6_uc010jvs.2_Missense_Mutation_p.A173T|DEF6_uc010jvt.2_Intron	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	173						cytoplasm|nucleus|plasma membrane					0						GGCCCAGGTGGCCCAGACCAC	0.647													A	35280172	A	A	35280172	3	1	235	1	0	0	0	0	1	0	0	0	4386	1203	42	3	531	3	DEF6	6	35280172	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	2909209	35280172	135834895	27	16652											
PKHD1	5314	broad.mit.edu	37	chr6	51799070	51799070	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accatcagaaacaaggatggCgtgtgccctgagctcgatgg	13	10	1	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr6:51799070C>T	uc003pah.1	-	37	6235	c.5959G>A	c.(5959-5961)GCC>ACC	p.A1987T	PKHD1_uc010jzn.1_Missense_Mutation_p.A12T|PKHD1_uc003pai.2_Missense_Mutation_p.A1987T	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1987	Extracellular (Potential).|G8 1.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ACAAGGATGGCGTGTGCCCTG	0.542											OREG0017491	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	51799070	T	T	51799070	3	4	235	1	0	0	0	0	1	0	0	0	11971	768	27	1	6428	1	PKHD1	6	51799070	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	16518898	51799070	119315997	28	16653											
MTHFD1L	25902	broad.mit.edu	37	chr6	151336802	151336802	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggctgcgagtaaaagaagCcgattccagttcctgtatga	12	8	0	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr6:151336802C>T	uc003qob.2	+	24	2827	c.2559C>T	c.(2557-2559)AGC>AGT	p.S853S	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Silent_p.S854S|MTHFD1L_uc003qoc.2_Silent_p.S801S	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	853	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		GTAAAAGAAGCCGATTCCAGT	0.463													T	151336802	T	T	151336802	2	4	235	1	0	0	0	0	0	0	0	1	9928	738	26	3		3	MTHFD1L	6	151336802	Silent	SNP	C	TCGA-32-4208-01A-01D-1353-08	99537732	151336802	19778265	29	16654											
ADAP1	11033	broad.mit.edu	37	chr7	943765	943765	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgctcgccagcacccacctTcccgtcctcatggtagatga	9	16	1	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr7:943765T>C	uc003sjo.3	-	6	822	c.646A>G	c.(646-648)AAG>GAG	p.K216E	ADAP1_uc003sjm.3_Missense_Mutation_p.K42E|ADAP1_uc011jvs.1_Missense_Mutation_p.K121E|ADAP1_uc003sjn.3_Missense_Mutation_p.K144E|ADAP1_uc010ksc.2_Missense_Mutation_p.K144E	NM_006869	NP_006860	O75689	ADAP1_HUMAN	centaurin, alpha 1	216	PH 1.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			upper_aerodigestive_tract(1)	1						GCACCCACCTTCCCGTCCTCA	0.672													C	943765	C	C	943765	3	2	235	1	0	0	0	0	1	0	0	0	279	1792	62	4	502	4	ADAP1	7	943765	Missense_Mutation	SNP	T	TCGA-32-4208-01A-01D-1353-08		943765	158194898	30	16655											
ZMIZ2	83637	broad.mit.edu	37	chr7	44798997	44798997	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctaccctgggcacaggctgCccctgcagcagggcatgacc	12	17	0	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr7:44798997C>T	uc003tlr.2	+	7	1054	c.931C>T	c.(931-933)CCC>TCC	p.P311S	ZMIZ2_uc003tlq.2_Missense_Mutation_p.P279S|ZMIZ2_uc003tls.2_Missense_Mutation_p.P311S|ZMIZ2_uc003tlt.2_5'Flank|ZMIZ2_uc010kyj.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	311	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						GCACAGGCTGCCCCTGCAGCA	0.687													T	44798997	T	T	44798997	3	4	235	1	0	0	0	0	1	0	0	0	17694	739	26	3	953	3	ZMIZ2	7	44798997	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	43855232	44798997	114339666	31	16656											
CLIP2	7461	broad.mit.edu	37	chr7	73790959	73790959	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaaactggacgtggagtaccGgggccaggcgcaggctatcg	16	10	0	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr7:73790959G>C	uc003uam.2	+	10	2555	c.2228G>C	c.(2227-2229)CGG>CCG	p.R743P	CLIP2_uc003uan.2_Missense_Mutation_p.R708P|CLIP2_uc003uao.2_Missense_Mutation_p.R137P	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	743	Potential.					microtubule associated complex				skin(3)	3						GTGGAGTACCGGGGCCAGGCG	0.657													C	73790959	C	C	73790959	3	2	235	1	0	0	0	0	1	0	0	0	3533	1116	39	5	2262	5	CLIP2	7	73790959	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	28991962	73790959	85347704	32	16657											
OPN1SW	611	broad.mit.edu	37	chr7	128415066	128415066	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cagccaaagaagggtgggatGgagacgccaataccaatggt	14	8	0	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr7:128415066G>T	uc003vnt.3	-	2	495	c.495C>A	c.(493-495)TCC>TCA	p.S165S		NM_001708	NP_001699	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	165	Helical; Name=4; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0						AGGGTGGGATGGAGACGCCAA	0.552													T	128415066	T	T	128415066	2	4	235	1	0	0	0	0	0	0	0	1	10880	1335	47	5		5	OPN1SW	7	128415066	Silent	SNP	G	TCGA-32-4208-01A-01D-1353-08	54624107	128415066	30723597	33	16658											
ABCF2	10061	broad.mit.edu	37	chr7	150915908	150915908	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagcgtcttctccttgctctGggcctgccgggccagcttgg	13	14	3	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr7:150915908G>A	uc003wjp.2	-	9	1180	c.1069C>T	c.(1069-1071)CAG>TAG	p.Q357*	ABCF2_uc003wjo.1_Nonsense_Mutation_p.Q357*	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	357						ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCCTTGCTCTGGGCCTGCCGG	0.428													A	150915908	A	A	150915908	4	1	235	1	0	0	0	0	0	1	0	0	66	1357	47	3	871	3	ABCF2	7	150915908	Nonsense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	22500842	150915908	8222755	34	16659											
RAB11FIP1	80223	broad.mit.edu	37	chr8	37730590	37730590	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caccatgtcccaattcagagGggacagatgcctggccagag	12	12	1	3			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr8:37730590G>T	uc003xkm.1	-	4	1774	c.1730C>A	c.(1729-1731)CCC>CAC	p.P577H	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_5'UTR|RAB11FIP1_uc003xko.1_5'UTR|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	577	Ser-rich.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CAATTCAGAGGGGACAGATGC	0.557													T	37730590	T	T	37730590	3	4	235	1	0	0	0	0	1	0	0	0	12893	1232	43	5	2133	5	RAB11FIP1	8	37730590	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08		37730590	108633432	35	16660											
RALYL	138046	broad.mit.edu	37	chr8	85774532	85774532	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatttgtgttttgtaaaggTtatttgattaccacgggcgt	10	6	0	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr8:85774532T>C	uc003ycq.3	+	7	831	c.415T>C	c.(415-417)TTA>CTA	p.L139L	RALYL_uc003ycr.3_Silent_p.L139L|RALYL_uc003ycs.3_Silent_p.L139L|RALYL_uc010lzy.2_Silent_p.L128L|RALYL_uc003yct.3_Silent_p.L152L|RALYL_uc003ycu.3_Silent_p.L66L|RALYL_uc003ycv.3_Silent_p.L51L	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	139							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						TTTGTAAAGGTTATTTGATTA	0.473													C	85774532	C	C	85774532	2	2	235	1	0	0	0	0	0	0	0	1	13020	1739	60	4		4	RALYL	8	85774532	Silent	SNP	T	TCGA-32-4208-01A-01D-1353-08	48043942	85774532	60589490	36	16661											
PLEC	5339	broad.mit.edu	37	chr8	144991998	144991998	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agcttgtccttgaactcgggGcccacaatgcccatacgcac	9	15	0	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr8:144991998G>C	uc003zaf.1	-	32	12572	c.12402C>G	c.(12400-12402)GGC>GGG	p.G4134G	PLEC_uc003zab.1_Silent_p.G3997G|PLEC_uc003zac.1_Silent_p.G4001G|PLEC_uc003zad.2_Silent_p.G3997G|PLEC_uc003zae.1_Silent_p.G3965G|PLEC_uc003zag.1_Silent_p.G3975G|PLEC_uc003zah.2_Silent_p.G3983G|PLEC_uc003zaj.2_Silent_p.G4024G	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4134	Plectin 23.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TGAACTCGGGGCCCACAATGC	0.622													C	144991998	C	C	144991998	2	2	235	1	0	0	0	0	0	0	0	1	12052	1190	42	5		5	PLEC	8	144991998	Silent	SNP	G	TCGA-32-4208-01A-01D-1353-08	59217466	144991998	1372024	37	16662											
UNC13B	10497	broad.mit.edu	37	chr9	35386179	35386179	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggtacaagaactgcaaagCcctccaagagccagccaggt	10	13	0	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr9:35386179C>T	uc003zwq.2	+	23	3028	c.2736C>T	c.(2734-2736)AGC>AGT	p.S912S	UNC13B_uc003zwr.2_Silent_p.S912S	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	912					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			AACTGCAAAGCCCTCCAAGAG	0.483													T	35386179	T	T	35386179	2	4	235	1	0	0	0	0	0	0	0	1	16982	738	26	3		3	UNC13B	9	35386179	Silent	SNP	C	TCGA-32-4208-01A-01D-1353-08		35386179	105827252	38	16663											
ZNF658	26149	broad.mit.edu	37	chr9	40772547	40772547	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cccacattcactgcattcatAgggtttctcccctgagcgag	8	14	3	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr9:40772547A>C	uc004abs.2	-	5	2880	c.2728T>G	c.(2728-2730)TAT>GAT	p.Y910D	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.Y910D	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	910	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CTGCATTCATAGGGTTTCTCC	0.448													C	40772547	C	C	40772547	3	2	235	1	0	0	0	0	1	0	0	0	18066	420	15	5	455	5	ZNF658	9	40772547	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08	5386368	40772547	100440884	39	16664											
ANKRD16	54522	broad.mit.edu	37	chr10	5929963	5929963	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttcttcaggagtggattggCgccatgttccaccagctcct	11	12	2	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr10:5929963C>T	uc010qat.1	-	2	925	c.382G>A	c.(382-384)GCC>ACC	p.A128T	ANKRD16_uc009xie.2_Missense_Mutation_p.A128T|ANKRD16_uc009xif.2_Missense_Mutation_p.A128T|ANKRD16_uc001iiq.2_Missense_Mutation_p.A128T|FBXO18_uc001iir.2_5'Flank|FBXO18_uc001iis.2_5'Flank|FBXO18_uc009xig.2_5'Flank	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	128	ANK 3.										0						AGTGGATTGGCGCCATGTTCC	0.552													T	5929963	T	T	5929963	3	4	235	1	0	0	0	0	1	0	0	0	645	768	27	1	727	1	ANKRD16	10	5929963	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08		5929963	129604784	40	16665											
ERCC6	2074	broad.mit.edu	37	chr10	50690763	50690763	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagcatttgaatatcccccCatggtgatggggacggagaa	13	8	0	3			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr10:50690763C>T	uc001jhs.3	-	10	2293	c.2139G>A	c.(2137-2139)ATG>ATA	p.M713I	ERCC6_uc010qgr.1_Missense_Mutation_p.M83I|ERCC6_uc001jhr.3_Missense_Mutation_p.M113I	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	713					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						AATATCCCCCCATGGTGATGG	0.408								Direct_reversal_of_damage|NER					T	50690763	T	T	50690763	3	4	235	1	0	0	0	0	1	0	0	0	5217	594	21	3	2390	3	ERCC6	10	50690763	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	44760800	50690763	84843984	41	16666											
HECTD2	143279	broad.mit.edu	37	chr10	93244394	93244394	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtggattccatcagccgctAaagtgttggctttacttagt	11	8	1	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr10:93244394A>G	uc001khl.2	+	9	1052	c.952A>G	c.(952-954)AAA>GAA	p.K318E	LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Missense_Mutation_p.K322E|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_5'UTR|HECTD2_uc001khn.1_5'UTR	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	318					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						ATCAGCCGCTAAAGTGTTGGC	0.333													G	93244394	G	G	93244394	3	3	235	1	0	0	0	0	1	0	0	0	7040	363	13	4	1010	4	HECTD2	10	93244394	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08	42553631	93244394	42290353	42	16667											
NUP98	4928	broad.mit.edu	37	chr11	3744479	3744479	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgtttcttcactgcttcctTccagcccatttcgcaaagca	5	15	2	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr11:3744479T>C	uc001lyh.2	-	16	2345	c.2054A>G	c.(2053-2055)GAA>GGA	p.E685G	NUP98_uc001lyi.2_Missense_Mutation_p.E685G|NUP98_uc001lyj.1_Missense_Mutation_p.E685G|NUP98_uc001lyk.1_Missense_Mutation_p.E702G	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	702					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		ACTGCTTCCTTCCAGCCCATT	0.433			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								C	3744479	C	C	3744479	3	2	235	1	0	0	0	0	1	0	0	0	10773	1783	62	4	3441	4	NUP98	11	3744479	Missense_Mutation	SNP	T	TCGA-32-4208-01A-01D-1353-08		3744479	131262037	43	16668											
GALNTL4	374378	broad.mit.edu	37	chr11	11470460	11470460	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgaagggctcggcctctgCctcctcaggcttggcaggag	15	12	2	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr11:11470460C>T	uc001mjo.2	-	2	680	c.259G>A	c.(259-261)GCA>ACA	p.A87T		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	87	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		TCGGCCTCTGCCTCCTCAGGC	0.602													T	11470460	T	T	11470460	3	4	235	1	0	0	0	0	1	0	0	0	6223	739	26	3	1604	3	GALNTL4	11	11470460	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	7725981	11470460	123536056	44	16669											
CDC42BPG	55561	broad.mit.edu	37	chr11	64602005	64602005	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactgcagctccagcctggcCgaggcctccatcttctgcag	11	16	2	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr11:64602005C>T	uc001obs.3	-	19	2220	c.2220G>A	c.(2218-2220)TCG>TCA	p.S740S		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	740	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						CCAGCCTGGCCGAGGCCTCCA	0.672													T	64602005	T	T	64602005	2	4	235	1	0	0	0	0	0	0	0	1	3074	639	23	2		2	CDC42BPG	11	64602005	Silent	SNP	C	TCGA-32-4208-01A-01D-1353-08	53131545	64602005	70404511	45	16670											
CREBZF	58487	broad.mit.edu	37	chr11	85375510	85375510	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tccacaggccgccgctatccGagcctccgccagacgaggag	12	17	0	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr11:85375510G>C	uc001pas.2	-	1	673	c.410C>G	c.(409-411)TCG>TGG	p.S137W	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	137					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				GCCGCTATCCGAGCCTCCGCC	0.637													C	85375510	C	C	85375510	3	2	235	1	0	0	0	0	1	0	0	0	3863	1059	37	5	658	5	CREBZF	11	85375510	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	20773505	85375510	49631006	46	16671											
C12orf60	144608	broad.mit.edu	37	chr12	14975979	14975979	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaacacactgactgaattgtTtagccgcagtatgaatactc	7	9	0	3			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr12:14975979T>G	uc001rcj.3	+	2	314	c.110T>G	c.(109-111)TTT>TGT	p.F37C		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	37										ovary(1)|central_nervous_system(1)	2						ACTGAATTGTTTAGCCGCAGT	0.343													G	14975979	G	G	14975979	3	3	235	1	0	0	0	0	1	0	0	0	1703	1841	64	5	112	5	C12orf60	12	14975979	Missense_Mutation	SNP	T	TCGA-32-4208-01A-01D-1353-08		14975979	118875916	47	16672											
LEMD3	23592	broad.mit.edu	37	chr12	65632357	65632357	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaatggaaaagatgttggaAtaaggtaaaggatctgattt	11	1	1	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr12:65632357A>G	uc001ssl.1	+	5	1777	c.1771A>G	c.(1771-1773)ATA>GTA	p.I591V	LEMD3_uc009zqo.1_Missense_Mutation_p.I590V	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	591					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		AGATGTTGGAATAAGGTAAAG	0.313													G	65632357	G	G	65632357	3	3	235	1	0	0	0	0	1	0	0	0	8721	101	4	4	1789	4	LEMD3	12	65632357	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08	50656378	65632357	68219538	48	16673											
ANO4	121601	broad.mit.edu	37	chr12	101480543	101480543	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	taatcaggaataactctcagGttgcaaccacagggactgct	9	10	2	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr12:101480543G>C	uc010svm.1	+	17	2214	c.1642G>C	c.(1642-1644)GTT>CTT	p.V548L	ANO4_uc001thw.2_Missense_Mutation_p.V513L|ANO4_uc001thx.2_Missense_Mutation_p.V548L|ANO4_uc001thy.2_Missense_Mutation_p.V68L	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	548	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TAACTCTCAGGTTGCAACCAC	0.493										HNSCC(74;0.22)			C	101480543	C	C	101480543	3	2	235	1	0	0	0	0	1	0	0	0	699	1261	44	5	1595	5	ANO4	12	101480543	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	35848186	101480543	32371352	49	16674											
MPHOSPH8	54737	broad.mit.edu	37	chr13	20233374	20233374	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgctgtgaaaaatggggattAtattactgtaaaagttgcac	10	4	0	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr13:20233374A>G	uc001umh.2	+	7	1745	c.1736A>G	c.(1735-1737)TAT>TGT	p.Y579C	MPHOSPH8_uc001umg.2_Missense_Mutation_p.Y579C	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	579					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		AATGGGGATTATATTACTGTA	0.284													G	20233374	G	G	20233374	3	3	235	1	0	0	0	0	1	0	0	0	9727	449	16	4	1762	4	MPHOSPH8	13	20233374	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08		20233374	94936504	50	16675											
PAN3	255967	broad.mit.edu	37	chr13	28794497	28794497	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catccatgggaagccctgctActgctggattagcgccaggt	12	12	0	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr13:28794497A>G	uc001urz.2	+	5	552	c.544A>G	c.(544-546)ACT>GCT	p.T182A	PAN3_uc010tdo.1_Missense_Mutation_p.T328A|PAN3_uc001ury.2_5'UTR|PAN3_uc001urx.2_Missense_Mutation_p.T128A	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	328	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		AAGCCCTGCTACTGCTGGATT	0.438													G	28794497	G	G	28794497	3	3	235	1	0	0	0	0	1	0	0	0	11415	391	14	4	1004	4	PAN3	13	28794497	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08	8561123	28794497	86375381	51	16676											
FRY	10129	broad.mit.edu	37	chr13	32808846	32808846	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcagcacatgccttatctgAccttctctcaagattggtgg	9	11	4	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr13:32808846A>G	uc001utx.2	+	42	6159	c.5663A>G	c.(5662-5664)GAC>GGC	p.D1888G	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1888					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GCCTTATCTGACCTTCTCTCA	0.517													G	32808846	G	G	32808846	3	3	235	1	0	0	0	0	1	0	0	0	6063	275	10	4	5829	4	FRY	13	32808846	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08	4014349	32808846	82361032	52	16677											
RAP2A	5911	broad.mit.edu	37	chr13	98086962	98086962	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agaacggccagggcttcatcCtcgtctacagcctcgtcaac	9	15	3	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr13:98086962C>G	uc001vnd.2	+	1	488	c.238C>G	c.(238-240)CTC>GTC	p.L80V		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	80					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			GGGCTTCATCCTCGTCTACAG	0.632													G	98086962	G	G	98086962	3	3	235	1	0	0	0	0	1	0	0	0	13040	681	24	5	240	5	RAP2A	13	98086962	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	65278116	98086962	17082916	53	16678											
OSGEP	55644	broad.mit.edu	37	chr14	20922812	20922812	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccacgccaatcttattggCgctgccttcaaaacccagca	7	16	2	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr14:20922812C>T	uc001vxf.2	-	1	387	c.31G>A	c.(31-33)GCC>ACC	p.A11T	APEX1_uc001vxg.2_5'Flank|APEX1_uc001vxh.2_5'Flank|APEX1_uc001vxi.2_5'Flank|APEX1_uc001vxj.2_5'Flank	NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	11					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		ATCTTATTGGCGCTGCCTTCA	0.632													T	20922812	T	T	20922812	3	4	235	1	0	0	0	0	1	0	0	0	11287	768	27	1	1020	1	OSGEP	14	20922812	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08		20922812	86426728	54	16679											
C14orf166B	145497	broad.mit.edu	37	chr14	77292858	77292858	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	catgcacatccaattcccatCaaagcctactcttcccaggg	5	16	2	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr14:77292858C>G	uc001xsx.2	+	1	134	c.20C>G	c.(19-21)TCA>TGA	p.S7*	C14orf166B_uc010asn.1_Translation_Start_Site|C14orf166B_uc001xsw.2_RNA|C14orf166B_uc010aso.1_RNA|C14orf166B_uc010tvg.1_RNA	NM_194287	NP_919263	Q0VAA2	CN16B_HUMAN	hypothetical protein LOC145497	7											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		CAATTCCCATCAAAGCCTACT	0.547													G	77292858	G	G	77292858	4	3	235	1	0	0	0	0	0	1	0	0	1757	838	29	5	22	5	C14orf166B	14	77292858	Nonsense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	56370046	77292858	30056682	55	16680											
HERC2	8924	broad.mit.edu	37	chr15	28474893	28474893	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaattcagcaattgtaCtgaggagtggagactgcgga	15	6	1	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr15:28474893C>A	uc001zbj.2	-	32	5016	c.4910G>T	c.(4909-4911)AGT>ATT	p.S1637I		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1637					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGCAATTGTACTGAGGAGTGG	0.428													A	28474893	A	A	28474893	3	1	235	1	0	0	0	0	1	0	0	0	7058	565	20	5	9842	5	HERC2	15	28474893	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08		28474893	74056499	56	16681											
MYO1E	4643	broad.mit.edu	37	chr15	59502739	59502739	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gttctctatgaggtcacataCgattttattattaaagtact	6	6	2	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr15:59502739C>G	uc002aga.2	-	13	1708	c.1336G>C	c.(1336-1338)GTA>CTA	p.V446L		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	446	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		AGGTCACATACGATTTTATTA	0.348													G	59502739	G	G	59502739	3	3	235	1	0	0	0	0	1	0	0	0	10072	536	19	5	2054	5	MYO1E	15	59502739	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	31027846	59502739	43028653	57	16682											
C16orf59	80178	broad.mit.edu	37	chr16	2512205	2512205	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attccacggatgccgccgctGccaaaacccagttcctccag	8	17	0	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr16:2512205G>A	uc002cqh.2	+	6	746	c.715G>A	c.(715-717)GCC>ACC	p.A239T	C16orf59_uc002cqf.1_Missense_Mutation_p.A239T|C16orf59_uc002cqg.1_Missense_Mutation_p.A72T|C16orf59_uc002cqi.2_Missense_Mutation_p.A72T|C16orf59_uc010uwb.1_Missense_Mutation_p.A72T	NM_025108	NP_079384	Q7L2K0	CP059_HUMAN	hypothetical protein LOC80178	239											0		Ovarian(90;0.17)				TGCCGCCGCTGCCAAAACCCA	0.612													A	2512205	A	A	2512205	3	1	235	1	0	0	0	0	1	0	0	0	1823	1319	46	3	737	3	C16orf59	16	2512205	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08		2512205	87842548	58	16683											
TMC5	79838	broad.mit.edu	37	chr16	19477522	19477522	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcttcacaatcggagcatGcttgaccacctgcttcttca	6	14	4	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr16:19477522G>A	uc002dgc.3	+	9	2353	c.1604G>A	c.(1603-1605)TGC>TAC	p.C535Y	TMC5_uc010vaq.1_Missense_Mutation_p.C535Y|TMC5_uc002dgb.3_Missense_Mutation_p.C535Y|TMC5_uc010var.1_Missense_Mutation_p.C535Y|TMC5_uc002dgd.1_Missense_Mutation_p.C289Y|TMC5_uc002dge.3_Missense_Mutation_p.C289Y|TMC5_uc002dgf.3_Missense_Mutation_p.C218Y|TMC5_uc002dgg.3_Missense_Mutation_p.C176Y	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	535	Helical; (Potential).					integral to membrane				skin(1)	1						ATCGGAGCATGCTTGACCACC	0.458													A	19477522	A	A	19477522	3	1	235	1	0	0	0	0	1	0	0	0	15985	1319	46	3	1944	3	TMC5	16	19477522	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	16965317	19477522	70877231	59	16684											
SCNN1B	6338	broad.mit.edu	37	chr16	23360058	23360058	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgcatcatctgtgaggggccCaagaagaaagccatgtggtt	13	9	2	3			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr16:23360058C>A	uc002dln.2	+	2	314	c.138C>A	c.(136-138)CCC>CCA	p.P46P		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	46	Cytoplasmic (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	GTGAGGGGCCCAAGAAGAAAG	0.612													A	23360058	A	A	23360058	2	1	235	1	0	0	0	0	0	0	0	1	13928	581	21	5		5	SCNN1B	16	23360058	Silent	SNP	C	TCGA-32-4208-01A-01D-1353-08	3882536	23360058	66994695	60	16685											
OR1A2	26189	broad.mit.edu	37	chr17	3101531	3101531	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	attcaaagccttctgcacctGtggctcccacctcacagttg	7	15	3	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr17:3101531G>C	uc002fvd.1	+	1	719	c.719G>C	c.(718-720)TGT>TCT	p.C240S		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TTCTGCACCTGTGGCTCCCAC	0.438													C	3101531	C	C	3101531	3	2	235	1	0	0	0	0	1	0	0	0	10950	1377	48	5	721	5	OR1A2	17	3101531	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08		3101531	78093679	61	16686											
DLG4	1742	broad.mit.edu	37	chr17	7099833	7099833	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatcgtgaccgtctgacccGcattcttcagggcaatggca	11	12	3	3			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr17:7099833G>A	uc002get.3	-	12	2475	c.1274C>T	c.(1273-1275)GCG>GTG	p.A425V	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Missense_Mutation_p.A322V|DLG4_uc010cly.2_Missense_Mutation_p.A379V|DLG4_uc010vto.1_Missense_Mutation_p.A422V	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	382	PDZ 3.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						CGTCTGACCCGCATTCTTCAG	0.542													A	7099833	A	A	7099833	3	1	235	1	0	0	0	0	1	0	0	0	4557	1087	38	1	1073	1	DLG4	17	7099833	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	3998302	7099833	74095377	62	16687											
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	13	14	3	0	rs28934578		TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578406	T	T	7578406	3	4	235	1	0	0	0	0	1	0	0	0	16378	768	27	1	774	1	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	478573	7578406	73616804	63	16688											
SFRS1	6426	broad.mit.edu	37	chr17	56083327	56083327	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcctgccaacttccacttggAggcagtcctgaaaaagtgat	9	11	0	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr17:56083327A>G	uc002ivi.2	-	3	596	c.387T>C	c.(385-387)CCT>CCC	p.P129P	SFRS1_uc002ivj.2_Silent_p.P129P	NM_006924	NP_008855	Q07955	SRSF1_HUMAN	splicing factor, arginine/serine-rich 1 isoform	129	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA 5'-splice site recognition|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytoplasm|nuclear speck	nucleotide binding|RNA binding				0		Colorectal(1115;0.0691)		LUAD - Lung adenocarcinoma(1115;0.247)		TTCCACTTGGAGGCAGTCCTG	0.388													G	56083327	G	G	56083327	2	3	235	1	0	0	0	0	0	0	0	1	14165	291	11	4		4	SFRS1	17	56083327	Silent	SNP	A	TCGA-32-4208-01A-01D-1353-08	48504921	56083327	25111883	64	16689											
KCNH6	81033	broad.mit.edu	37	chr17	61613357	61613357	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttcagcagcctcaccagcGtgggcttcggcaatgtctcg	11	15	3	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr17:61613357G>A	uc002jay.2	+	6	1509	c.1429G>A	c.(1429-1431)GTG>ATG	p.V477M	KCNH6_uc002jax.1_Missense_Mutation_p.V477M|KCNH6_uc010wpl.1_Missense_Mutation_p.V354M|KCNH6_uc010wpm.1_Missense_Mutation_p.V477M|KCNH6_uc002jaz.1_Missense_Mutation_p.V424M	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	477	Selectivity filter (By similarity).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCTCACCAGCGTGGGCTTCGG	0.602													A	61613357	A	A	61613357	3	1	235	1	0	0	0	0	1	0	0	0	8036	1145	40	1	1451	1	KCNH6	17	61613357	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	5530030	61613357	19581853	65	16690											
FAM20A	54757	broad.mit.edu	37	chr17	66551780	66551780	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accgggagtagagcccatggCggttaatacccaggtggaac	14	10	0	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr17:66551780C>T	uc002jho.2	-	2	797	c.509G>A	c.(508-510)CGC>CAC	p.R170H	FAM20A_uc010wqp.1_Missense_Mutation_p.R32H|FAM20A_uc002jhn.2_5'UTR	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	170						extracellular region					0	Breast(10;1.64e-13)					GAGCCCATGGCGGTTAATACC	0.562													T	66551780	T	T	66551780	3	4	235	1	0	0	0	0	1	0	0	0	5537	768	27	1	1156	1	FAM20A	17	66551780	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	4938423	66551780	14643430	66	16691											
DSC2	1824	broad.mit.edu	37	chr18	28654745	28654745	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atggataggctcatcaggatCaaccgcaacaatctccgcag	9	12	4	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr18:28654745C>G	uc002kwl.3	-	12	2246	c.1792G>C	c.(1792-1794)GAT>CAT	p.D598H	DSC2_uc002kwk.3_Missense_Mutation_p.D598H	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	598	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TCATCAGGATCAACCGCAACA	0.428													G	28654745	G	G	28654745	3	3	235	1	0	0	0	0	1	0	0	0	4766	826	29	5	973	5	DSC2	18	28654745	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08		28654745	49422503	67	16692											
GALNT1	2589	broad.mit.edu	37	chr18	33234759	33234759	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggagagaggacttcctgctGgagatggtgagtgacatttt	15	5	0	4			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr18:33234759G>A	uc010dmu.2	+	2	186	c.133G>A	c.(133-135)GGA>AGA	p.G45R	GALNT1_uc002kyz.3_5'UTR|GALNT1_uc002kza.2_Missense_Mutation_p.G45R|GALNT1_uc002kzb.2_Missense_Mutation_p.G45R	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	45	Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						ACTTCCTGCTGGAGATGGTGA	0.338													A	33234759	A	A	33234759	3	1	235	1	0	0	0	0	1	0	0	0	6207	1349	47	3	135	3	GALNT1	18	33234759	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	4580014	33234759	44842489	68	16693											
APC2	10297	broad.mit.edu	37	chr19	1468647	1468647	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacacagaagaccacgcccGgggtgccagctgtgctccgg	14	15	0	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr19:1468647G>A	uc002lsr.1	+	15	5555	c.5347G>A	c.(5347-5349)GGG>AGG	p.G1783R	APC2_uc002lss.1_Missense_Mutation_p.G1365R|APC2_uc002lst.1_Missense_Mutation_p.G1783R|APC2_uc002lsu.1_Missense_Mutation_p.G1782R|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1783	Pro-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACCACGCCCGGGGTGCCAGC	0.721													A	1468647	A	A	1468647	3	1	235	1	0	0	0	0	1	0	0	0	764	1116	39	2	5401	2	APC2	19	1468647	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08		1468647	57660336	69	16694											
CDC37	11140	broad.mit.edu	37	chr19	10505756	10505756	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccacctttaggctcttggCcagctccaggataaattgca	9	12	1	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr19:10505756C>T	uc002mof.1	-	5	783	c.667G>A	c.(667-669)GCC>ACC	p.A223T	CDC37_uc002moe.1_Missense_Mutation_p.A178T|CDC37_uc010dxf.1_Missense_Mutation_p.A60T|CDC37_uc002mog.1_Intron|CDC37_uc002moh.2_Missense_Mutation_p.A223T	NM_007065	NP_008996	Q16543	CDC37_HUMAN	cell division cycle 37 protein	223					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		AGGCTCTTGGCCAGCTCCAGG	0.592													T	10505756	T	T	10505756	3	4	235	1	0	0	0	0	1	0	0	0	3068	739	26	3	485	3	CDC37	19	10505756	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	9037109	10505756	48623227	70	16695											
FAM129C	199786	broad.mit.edu	37	chr19	17649991	17649991	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaggcccctgctgcccggGccttcctggacgccgtccga	13	19	0	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr19:17649991G>A	uc010xpr.1	+	7	859	c.721G>A	c.(721-723)GCC>ACC	p.A241T	FAM129C_uc010xpq.1_Missense_Mutation_p.A241T|FAM129C_uc002ngy.3_5'UTR|FAM129C_uc010xpu.1_5'UTR|FAM129C_uc002ngz.3_RNA|FAM129C_uc010eaw.2_5'UTR|FAM129C_uc002nhb.2_5'Flank	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	241											0						TGCTGCCCGGGCCTTCCTGGA	0.697													A	17649991	A	A	17649991	3	1	235	1	0	0	0	0	1	0	0	0	5438	1203	42	3	747	3	FAM129C	19	17649991	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	7144235	17649991	41478992	71	16696											
CD177	57126	broad.mit.edu	37	chr19	43865711	43865711	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgccactcattgttatgatgGgtacattcatctctcaggag	9	10	4	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr19:43865711G>T	uc002owi.2	+	9	1103	c.1061G>T	c.(1060-1062)GGG>GTG	p.G354V	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	354	UPAR/Ly6 2.				blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				TGTTATGATGGGTACATTCAT	0.398													T	43865711	T	T	43865711	3	4	235	1	0	0	0	0	1	0	0	0	2971	1232	43	5	1091	5	CD177	19	43865711	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	26215720	43865711	15263272	72	16697											
CRYBA4	1413	broad.mit.edu	37	chr22	27018564	27018564	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcaggaaggggccacaatgAccctgcaatgcacaaagtca	11	11	1	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr22:27018564A>G	uc003acz.3	+	2	39	c.4A>G	c.(4-6)ACC>GCC	p.T2A		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	2	N-terminal arm.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						GGCCACAATGACCCTGCAATG	0.552													G	27018564	G	G	27018564	3	3	235	1	0	0	0	0	1	0	0	0	3909	275	10	4	6	4	CRYBA4	22	27018564	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08		27018564	24286002	73	16698											
APOBEC3F	200316	broad.mit.edu	37	chr22	39436982	39436982	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggatgaagcctcacttcaGgtaccgctgcccgctctacc	9	15	3	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chr22:39436982G>A	uc003aww.2	+	1	310	c.17G>A	c.(16-18)AGA>AAA	p.R6K	APOBEC3F_uc003awv.2_Missense_Mutation_p.R6K|APOBEC3F_uc011aog.1_Missense_Mutation_p.R6K	NM_145298	NP_660341	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	6					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding				0	Melanoma(58;0.04)					CCTCACTTCAGGTACCGCTGC	0.647													A	39436982	A	A	39436982	3	1	235	1	0	0	0	0	1	0	0	0	793	1014	35	3	19	3	APOBEC3F	22	39436982	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	12418418	39436982	11867584	74	16699											
CLCN4	1183	broad.mit.edu	37	chrX	10181901	10181901	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgggtaccctttccttgacgTgaaggacgagtttactcacc	10	11	1	2			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chrX:10181901T>C	uc004csy.3	+	11	2187	c.1757T>C	c.(1756-1758)GTG>GCG	p.V586A	CLCN4_uc011mid.1_Missense_Mutation_p.V492A	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	586	Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						TTCCTTGACGTGAAGGACGAG	0.597													C	10181901	C	C	10181901	3	2	235	1	0	0	0	0	1	0	0	0	3465	1696	59	4	1791	4	CLCN4	23	10181901	Missense_Mutation	SNP	T	TCGA-32-4208-01A-01D-1353-08		10181901	145088659	75	16700											
NHS	4810	broad.mit.edu	37	chrX	17743937	17743937	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctgctctcaacatcttcacAgcccccagcacaaattaagt	4	16	3	0			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chrX:17743937A>T	uc004cxx.2	+	6	1986	c.1648A>T	c.(1648-1650)AGC>TGC	p.S550C	NHS_uc011mix.1_Missense_Mutation_p.S571C|NHS_uc004cxy.2_Missense_Mutation_p.S394C|NHS_uc004cxz.2_Missense_Mutation_p.S373C|NHS_uc004cya.2_Missense_Mutation_p.S273C	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	550						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					ACATCTTCACAGCCCCCAGCA	0.557													T	17743937	T	T	17743937	3	4	235	1	0	0	0	0	1	0	0	0	10411	188	7	5	1775	5	NHS	23	17743937	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08	7562036	17743937	137526623	76	16701											
SMC1A	8243	broad.mit.edu	37	chrX	53409449	53409449	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggcactgctattgcgggacAgggccttatagatctcatca	12	10	2	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chrX:53409449A>G	uc004dsg.2	-	21	3332	c.3263T>C	c.(3262-3264)CTG>CCG	p.L1088P	SMC1A_uc011moe.1_Missense_Mutation_p.L1066P	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	1088					cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						ATTGCGGGACAGGGCCTTATA	0.527													G	53409449	G	G	53409449	3	3	235	1	0	0	0	0	1	0	0	0	14781	188	7	4	458	4	SMC1A	23	53409449	Missense_Mutation	SNP	A	TCGA-32-4208-01A-01D-1353-08	35665512	53409449	101861111	77	16702											
ATRX	546	broad.mit.edu	37	chrX	76938029	76938029	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttgctgcttcttaggaagtcGatctcttaattccatgatgg	9	8	2	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chrX:76938029G>A	uc004ecp.3	-	9	2951	c.2719C>T	c.(2719-2721)CGA>TGA	p.R907*	ATRX_uc004ecq.3_Nonsense_Mutation_p.R869*|ATRX_uc004eco.3_Nonsense_Mutation_p.R692*|ATRX_uc004ecr.2_Nonsense_Mutation_p.R839*|ATRX_uc010nlx.1_Nonsense_Mutation_p.R878*|ATRX_uc010nly.1_Nonsense_Mutation_p.R852*	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	907					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.R907*(1)		haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTAGGAAGTCGATCTCTTAAT	0.418			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						A	76938029	A	A	76938029	4	1	235	1	0	0	0	0	0	1	0	0	1208	1066	37	2	4867	2	ATRX	23	76938029	Nonsense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	23528580	76938029	78332531	78	16703											
PGK1	5230	broad.mit.edu	37	chrX	77372859	77372860	+	Missense_Mutation	DNP	GC	CT	CT													ttccgagcttcactttccaaGctaggggatgtctatgtcaa							TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chrX:77372859_77372860GC>CT	uc004ecz.3	+	5	640_641	c.468_469GC>CT	c.(466-471)AAGCTA>AACTTA	p.K156N	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Missense_Mutation_p.K128N	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	156					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						CACTTTCCAAGCTAGGGGATGT	0.426													CT	77372860	CT	CT	77372859	3	2	235	1	0	0	0	0	1	0	0	0	11790	962	34	5	486	5	PGK1	23	77372859	Missense_Mutation	DNP	GC	TCGA-32-4208-01A-01D-1353-08	434830	77372859	77897701	79	16704											
CXorf57	55086	broad.mit.edu	37	chrX	105882786	105882786	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcttgacagctataagtgaaGtcaggaaggagattgaagac	12	5	2	5			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chrX:105882786G>C	uc004emi.3	+	9	1754	c.1603G>C	c.(1603-1605)GTC>CTC	p.V535L	CXorf57_uc004emj.3_Intron	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	535										ovary(1)|lung(1)|breast(1)	3						TATAAGTGAAGTCAGGAAGGA	0.363													C	105882786	C	C	105882786	3	2	235	1	0	0	0	0	1	0	0	0	4113	1029	36	5	1637	5	CXorf57	23	105882786	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	28509927	105882786	49387774	80	16705			1	42		2	2	12	G		2.913702e-05
CXorf57	55086	broad.mit.edu	37	chrX	105882797	105882797	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ataagtgaagtcaggaaggaGattgaagacttgcagtatag	13	3	1	4			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chrX:105882797G>C	uc004emi.3	+	9	1765	c.1614G>C	c.(1612-1614)GAG>GAC	p.E538D	CXorf57_uc004emj.3_Intron	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	538										ovary(1)|lung(1)|breast(1)	3						TCAGGAAGGAGATTGAAGACT	0.373													C	105882797	C	C	105882797	3	2	235	1	0	0	0	0	1	0	0	0	4113	933	33	5	1648	5	CXorf57	23	105882797	Missense_Mutation	SNP	G	TCGA-32-4208-01A-01D-1353-08	11	105882797	49387763	81	16706			1	42		2	2	12	G		2.913702e-05
SLITRK2	84631	broad.mit.edu	37	chrX	144906297	144906297	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttacctaaaaggcagtttgCcccttcctatgaatctcgac	6	13	1	1			TCGA-32-4208-01A-01D-1353-08	TCGA-32-4208-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	f76168d6-f1a9-4483-a9ae-67b55e741a77	1825b78f-cbf7-415c-81bc-5c2443270927	g.chrX:144906297C>T	uc004fcd.2	+	5	3344	c.2354C>T	c.(2353-2355)GCC>GTC	p.A785V	SLITRK2_uc010nsp.2_Missense_Mutation_p.A785V|SLITRK2_uc010nso.2_Missense_Mutation_p.A785V|SLITRK2_uc011mwq.1_Missense_Mutation_p.A785V|SLITRK2_uc011mwr.1_Missense_Mutation_p.A785V|SLITRK2_uc011mws.1_Missense_Mutation_p.A785V|SLITRK2_uc004fcg.2_Missense_Mutation_p.A785V|SLITRK2_uc011mwt.1_Missense_Mutation_p.A785V|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	785	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					AGGCAGTTTGCCCCTTCCTAT	0.453													T	144906297	T	T	144906297	3	4	235	1	0	0	0	0	1	0	0	0	14743	739	26	3	2356	3	SLITRK2	23	144906297	Missense_Mutation	SNP	C	TCGA-32-4208-01A-01D-1353-08	39023500	144906297	10364263	82	16707											
DNAJC11	55735	broad.mit.edu	37	chr1	6727822	6727822	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctctctctctctgcagccGctcaaactcctctcgaattt	4	16	5	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr1:6727822G>A	uc001aof.2	-	4	431	c.325C>T	c.(325-327)CGG>TGG	p.R109W	DNAJC11_uc010nzt.1_Missense_Mutation_p.R71W|DNAJC11_uc001aog.2_Missense_Mutation_p.R109W|DNAJC11_uc010nzu.1_Missense_Mutation_p.R19W	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	109					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTGCAGCCGCTCAAACTCC	0.522													A	6727822	A	A	6727822	3	1	236	1	0	0	0	0	1	0	0	0	4630	1086	38	1	1406	1	DNAJC11	1	6727822	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08		6727822	242522799	1	16708											
TDRKH	11022	broad.mit.edu	37	chr1	151755433	151755433	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	actgttgcactggctgggatCccaaggcccagggctatttt	12	11	0	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr1:151755433C>T	uc009wnb.1	-	2	248	c.66G>A	c.(64-66)GGG>GGA	p.G22G	TDRKH_uc001eyy.2_5'UTR|TDRKH_uc001ezb.3_Silent_p.G22G|TDRKH_uc001ezc.3_Silent_p.G22G|TDRKH_uc001eza.3_Silent_p.G22G|TDRKH_uc001ezd.3_Silent_p.G22G|TDRKH_uc010pdn.1_5'UTR	NM_006862	NP_006853	Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing isoform a	22							RNA binding	p.G22V(1)		ovary(1)|pancreas(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGGCTGGGATCCCAAGGCCCA	0.463													T	151755433	T	T	151755433	2	4	236	1	0	0	0	0	0	0	0	1	15734	842	30	3		3	TDRKH	1	151755433	Silent	SNP	C	TCGA-32-4209-01A-01D-1353-08	145027611	151755433	97495188	2	16709											
CRTC2	200186	broad.mit.edu	37	chr1	153921628	153921628	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cactcattggccggtggtaaGactgttgcccatgcccactg	11	13	1	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr1:153921628G>A	uc010ped.1	-	12	1707	c.1637C>T	c.(1636-1638)TCT>TTT	p.S546F	DENND4B_uc001fdd.1_5'Flank|CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Missense_Mutation_p.S82F	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	546					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCGGTGGTAAGACTGTTGCCC	0.597													A	153921628	A	A	153921628	3	1	236	1	0	0	0	0	1	0	0	0	3900	942	33	3	456	3	CRTC2	1	153921628	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08	2166195	153921628	95328993	3	16710											
OR10J3	441911	broad.mit.edu	37	chr1	159283999	159283999	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccatgccaaggccaatccCcagtgatccagaggccagtt	11	14	0	2			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr1:159283999C>T	uc010piu.1	-	1	451	c.451G>A	c.(451-453)GGG>AGG	p.G151R		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					AGGCCAATCCCCAGTGATCCA	0.507													T	159283999	T	T	159283999	3	4	236	1	0	0	0	0	1	0	0	0	10911	623	22	3	540	3	OR10J3	1	159283999	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	5362371	159283999	89966622	4	16711											
POU2F1	5451	broad.mit.edu	37	chr1	167358969	167358969	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agtttgccaagaccttcaaaCaaagacgaatcaaacttgga	7	9	2	2			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr1:167358969C>G	uc001gec.2	+	10	1051	c.889C>G	c.(889-891)CAA>GAA	p.Q297E	POU2F1_uc010plg.1_RNA|POU2F1_uc001ged.2_Missense_Mutation_p.Q295E|POU2F1_uc001gee.2_Missense_Mutation_p.Q297E|POU2F1_uc010plh.1_Missense_Mutation_p.Q234E|POU2F1_uc001gef.2_Missense_Mutation_p.Q309E|POU2F1_uc001geg.2_Missense_Mutation_p.Q195E	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	297	POU-specific.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						GACCTTCAAACAAAGACGAAT	0.438													G	167358969	G	G	167358969	3	3	236	1	0	0	0	0	1	0	0	0	12271	479	17	5	919	5	POU2F1	1	167358969	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	8074970	167358969	81891652	5	16712											
C1orf26	54823	broad.mit.edu	37	chr1	185143825	185143825	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttacttgttcagagagagaaGatgaaagaactcaagaaagg	11	4	2	6	rs146489629	byFrequency	TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr1:185143825G>C	uc001grg.3	+	5	660	c.546G>C	c.(544-546)AAG>AAC	p.K182N	C1orf26_uc001grh.3_Missense_Mutation_p.K182N	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	182											0						AGAGAGAGAAGATGAAAGAAC	0.353													C	185143825	C	C	185143825	3	2	236	1	0	0	0	0	1	0	0	0	2035	933	33	5	560	5	C1orf26	1	185143825	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08	17784856	185143825	64106796	6	16713											
CFH	3075	broad.mit.edu	37	chr1	196694295	196694295	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tagatgtacacttagttcctGatcgcaagaaagaccagtat	8	8	0	4			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr1:196694295G>A	uc001gtj.3	+	12	1981	c.1741G>A	c.(1741-1743)GAT>AAT	p.D581N		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	581	Sushi 10.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CTTAGTTCCTGATCGCAAGAA	0.343													A	196694295	A	A	196694295	3	1	236	1	0	0	0	0	1	0	0	0	3283	1290	45	3	1805	3	CFH	1	196694295	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08	11550470	196694295	52556326	7	16714											
HEATR5B	54497	broad.mit.edu	37	chr2	37295836	37295836	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attcttacctacggctttcaTttgttttccaatagcttggc	6	10	2	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr2:37295836T>C	uc002rpp.1	-	8	1261	c.1165A>G	c.(1165-1167)ATG>GTG	p.M389V		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	389							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				ACGGCTTTCATTTGTTTTCCA	0.353													C	37295836	C	C	37295836	3	2	236	1	0	0	0	0	1	0	0	0	7032	1493	52	4	5166	4	HEATR5B	2	37295836	Missense_Mutation	SNP	T	TCGA-32-4209-01A-01D-1353-08		37295836	205903537	8	16715											
EIF5B	9669	broad.mit.edu	37	chr2	99977775	99977777	+	In_Frame_Del	DEL	TGA	-	-													gtggaaatgtactctgggagTgatgatgatgatgattttaa							TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr2:99977775_99977777delTGA	uc002tab.2	+	4	595_597	c.411_413delTGA	c.(409-414)AGTGAT>AGT	p.D142del		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	142	Poly-Asp.				regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						ACTCTGGGAGTGATGATGATGAT	0.345													-	99977777	-	-	99977775	7	5	236	1	0	1	0	1	0	0	0	0	5044	1693	59	0	425	0	EIF5B	2	99977775	In_Frame_Del	DEL	TGA	TCGA-32-4209-01A-01D-1353-08	62681939	99977775	143221598	9	16716											
KIF5C	3800	broad.mit.edu	37	chr2	149793797	149793797	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttgtattttcgcccactaGgggaagctgcatgaccccca	10	12	0	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr2:149793797G>A	uc010zbu.1	+	4	660	c.292_splice	c.e4-1	p.G98_splice		NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C						microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		TCGCCCACTAGGGGAAGCTGC	0.512													A	149793797	A	A	149793797	5	1	236	1	0	0	0	0	0	0	1	0	8307	1014	35	3	227	3	KIF5C	2	149793797	Splice_Site	SNP	G	TCGA-32-4209-01A-01D-1353-08	49816022	149793797	93405576	10	16717											
STXBP5L	9515	broad.mit.edu	37	chr3	120871386	120871386	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgaaatctaaaagagcagaActgagagtttattatgatga	9	3	1	6			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr3:120871386A>G	uc003eec.3	+	8	872	c.732A>G	c.(730-732)GAA>GAG	p.E244E	STXBP5L_uc011bji.1_Silent_p.E244E	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	244	WD 4.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AAAGAGCAGAACTGAGAGTTT	0.333													G	120871386	G	G	120871386	2	3	236	1	0	0	0	0	0	0	0	1	15356	40	2	4		4	STXBP5L	3	120871386	Silent	SNP	A	TCGA-32-4209-01A-01D-1353-08		120871386	77151044	11	16718											
PEX5L	51555	broad.mit.edu	37	chr3	179616029	179616029	+	Frame_Shift_Del	DEL	T	-	-													ttatctgccgccctagagccTtttccctataacagtgaaat							TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr3:179616029delT	uc003fki.1	-	3	229	c.99delA	c.(97-99)AAAfs	p.K33fs	PEX5L_uc011bqd.1_5'UTR|PEX5L_uc011bqe.1_Intron|PEX5L_uc011bqf.1_5'UTR|PEX5L_uc003fkj.1_Intron|PEX5L_uc010hxd.1_Frame_Shift_Del_p.K31fs|PEX5L_uc011bqg.1_Frame_Shift_Del_p.K9fs|PEX5L_uc011bqh.1_Intron	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	33					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CCCTAGAGCCTTTTCCCTATA	0.413													-	179616029	-	-	179616029	7	5	236	1	0	1	0	1	0	0	0	0	11749	1606	56	0	1833	0	PEX5L	3	179616029	Frame_Shift_Del	DEL	T	TCGA-32-4209-01A-01D-1353-08	58744643	179616029	18406401	12	16719											
C3orf59	151963	broad.mit.edu	37	chr3	192517421	192517421	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tagccactggaagcttttggTccagcttttgcaccattcct	8	12	0	0	rs117555490	by1000genomes	TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr3:192517421T>C	uc011bsp.1	-	2	551	c.230A>G	c.(229-231)GAC>GGC	p.D77G		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	77											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		AAGCTTTTGGTCCAGCTTTTG	0.443													C	192517421	C	C	192517421	3	2	236	1	0	0	0	0	1	0	0	0	2237	1667	58	4	1249	4	C3orf59	3	192517421	Missense_Mutation	SNP	T	TCGA-32-4209-01A-01D-1353-08	12901392	192517421	5505009	13	16720											
NKX3-2	579	broad.mit.edu	37	chr4	13546023	13546023	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaggacgtcaaggtgttggCgccgcgcacagccatctgcg	15	12	2	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr4:13546023C>T	uc003gmx.2	-	1	92	c.16G>A	c.(16-18)GCC>ACC	p.A6T		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	6					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAGGTGTTGGCGCCGCGCACA	0.557													T	13546023	T	T	13546023	3	4	236	1	0	0	0	0	1	0	0	0	10456	768	27	1	993	1	NKX3-2	4	13546023	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08		13546023	177608253	14	16721											
GEMIN5	25929	broad.mit.edu	37	chr5	154275813	154275813	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggtgcccgtgttccaagtgtGgtaagaggaggagcttttgc	16	7	0	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr5:154275813G>C	uc003lvx.3	-	24	3519	c.3436C>G	c.(3436-3438)CAC>GAC	p.H1146D	GEMIN5_uc011ddk.1_Missense_Mutation_p.H1145D	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	1146					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTCCAAGTGTGGTAAGAGGAG	0.547													C	154275813	C	C	154275813	3	2	236	1	0	0	0	0	1	0	0	0	6331	1348	47	5	1110	5	GEMIN5	5	154275813	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08		154275813	26639447	15	16722											
AGXT2L2	85007	broad.mit.edu	37	chr5	177649920	177649920	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacactgggcagagactcagCgaagaaggctgcaatctgtg	13	10	2	2	rs142142484	byFrequency	TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr5:177649920C>T	uc003miz.2	-	7	886	c.634G>A	c.(634-636)GCT>ACT	p.A212T	AGXT2L2_uc003miy.2_5'UTR|AGXT2L2_uc003mjc.2_Missense_Mutation_p.A171T|AGXT2L2_uc003mja.2_RNA|AGXT2L2_uc003mjb.2_5'UTR|AGXT2L2_uc003mjd.1_Missense_Mutation_p.A70T	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	212						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	AGAGACTCAGCGAAGAAGGCT	0.587													T	177649920	T	T	177649920	3	4	236	1	0	0	0	0	1	0	0	0	407	768	27	1	742	1	AGXT2L2	5	177649920	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	23374107	177649920	3265340	16	16723											
BMP6	654	broad.mit.edu	37	chr6	7727630	7727630	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acgccctgtccgccgacaacGacgaggacggggcgtcggag	16	14	0	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr6:7727630G>A	uc003mxu.3	+	1	620	c.442G>A	c.(442-444)GAC>AAC	p.D148N		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	148					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CGCCGACAACGACGAGGACGG	0.682													A	7727630	A	A	7727630	3	1	236	1	0	0	0	0	1	0	0	0	1464	1058	37	2	444	2	BMP6	6	7727630	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08		7727630	163387437	17	16724											
NFKBIE	4794	broad.mit.edu	37	chr6	44229437	44229437	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctggccgcccttccagcaggCagcgggcacaggccaagtgc	14	16	0	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr6:44229437C>A	uc003oxe.1	-	3	1059	c.1034G>T	c.(1033-1035)TGC>TTC	p.C345F		NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	345	ANK 3.				cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTCCAGCAGGCAGCGGGCACA	0.632													A	44229437	A	A	44229437	3	1	236	1	0	0	0	0	1	0	0	0	10380	710	25	5	484	5	NFKBIE	6	44229437	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	36501807	44229437	126885630	18	16725											
COL19A1	1310	broad.mit.edu	37	chr6	70589454	70589454	+	Translation_Start_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggccgttcacatggtttcaaGgcacaatgagactcactggc	11	11	3	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr6:70589454G>T	uc003pfc.1	+	2	112	c.-5G>T	c.(-7--3)AAGGC>AATGC			NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor						cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						ATGGTTTCAAGGCACAATGAG	0.418													T	70589454	T	T	70589454	1	4	236	1	0	0	0	0	0	0	0	0	3676	1015	35	5		5	COL19A1	6	70589454	Translation_Start_Site	SNP	G	TCGA-32-4209-01A-01D-1353-08	26360017	70589454	100525613	19	16726											
RFPL4B	442247	broad.mit.edu	37	chr6	112671523	112671523	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcctgcaagccctcgccttCgccgtgtgggaattttcctg	10	14	0	0	rs143103700	byFrequency	TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr6:112671523C>T	uc003pvx.1	+	3	925	c.613C>T	c.(613-615)CGC>TGC	p.R205C		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	205	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CCCTCGCCTTCGCCGTGTGGG	0.448													T	112671523	T	T	112671523	3	4	236	1	0	0	0	0	1	0	0	0	13256	884	31	2	615	2	RFPL4B	6	112671523	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	42082069	112671523	58443544	20	16727											
DSE	29940	broad.mit.edu	37	chr6	116757341	116757341	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagctgcttctccttgtagaCcaaatacacctgggagagga	10	11	1	2			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr6:116757341C>A	uc003pws.2	+	6	1904	c.1710C>A	c.(1708-1710)GAC>GAA	p.D570E	DSE_uc011ebg.1_Missense_Mutation_p.D589E|DSE_uc003pwt.2_Missense_Mutation_p.D570E|DSE_uc003pwu.2_Missense_Mutation_p.D237E	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	570					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TCCTTGTAGACCAAATACACC	0.502													A	116757341	A	A	116757341	3	1	236	1	0	0	0	0	1	0	0	0	4774	506	18	5	1728	5	DSE	6	116757341	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	4085818	116757341	54357726	21	16728											
CLIP2	7461	broad.mit.edu	37	chr7	73771699	73771699	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagaagcagcagcacattgaGcagctgctggctgaacgaga	14	9	0	4			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr7:73771699G>A	uc003uam.2	+	6	1434	c.1107G>A	c.(1105-1107)GAG>GAA	p.E369E	CLIP2_uc003uan.2_Silent_p.E369E	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	369	Potential.					microtubule associated complex				skin(3)	3						AGCACATTGAGCAGCTGCTGG	0.617													A	73771699	A	A	73771699	2	1	236	1	0	0	0	0	0	0	0	1	3533	962	34	3		3	CLIP2	7	73771699	Silent	SNP	G	TCGA-32-4209-01A-01D-1353-08		73771699	85366964	22	16729											
PRUNE2	158471	broad.mit.edu	37	chr9	79321219	79321219	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctgatttgtttcttgaccttCattagttgaaacattagatg	7	6	2	4			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr9:79321219C>G	uc010mpk.2	-	8	6095	c.5971G>C	c.(5971-5973)GAA>CAA	p.E1991Q	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1991					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TCTTGACCTTCATTAGTTGAA	0.423													G	79321219	G	G	79321219	3	3	236	1	0	0	0	0	1	0	0	0	12641	835	29	5	3343	5	PRUNE2	9	79321219	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08		79321219	61892212	23	16730											
DAPK1	1612	broad.mit.edu	37	chr9	90266587	90266587	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtaaagatggcaacatgcCtatcgtggtggccctctgtg	12	9	1	1	rs36214022		TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr9:90266587C>T	uc004apc.2	+	17	1910	c.1772C>T	c.(1771-1773)CCT>CTT	p.P591L	DAPK1_uc004apd.2_Missense_Mutation_p.P591L|DAPK1_uc011ltg.1_Missense_Mutation_p.P591L|DAPK1_uc011lth.1_Missense_Mutation_p.P328L|DAPK1_uc004apf.1_Missense_Mutation_p.P145L	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	591	ANK 7.		P -> L.		apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						GGCAACATGCCTATCGTGGTG	0.498									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				T	90266587	T	T	90266587	3	4	236	1	0	0	0	0	1	0	0	0	4235	681	24	3	1834	3	DAPK1	9	90266587	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	10945368	90266587	50946844	24	16731											
TLL2	7093	broad.mit.edu	37	chr10	98155658	98155658	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcttggaaggtaagtcccaCgtgaaacccctctgaaaccg	10	12	1	2			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr10:98155658C>T	uc001kml.1	-	12	1730	c.1504G>A	c.(1504-1506)GTG>ATG	p.V502M	TLL2_uc009xvf.1_Missense_Mutation_p.V480M	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	502	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GTAAGTCCCACGTGAAACCCC	0.498											OREG0020398	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	98155658	T	T	98155658	3	4	236	1	0	0	0	0	1	0	0	0	15943	536	19	1	1583	1	TLL2	10	98155658	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08		98155658	37379089	25	16732											
CHUK	1147	broad.mit.edu	37	chr10	101960490	101960490	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtagctccatgatttcAgcatgcaaagacataatctg	7	9	3	2			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr10:101960490A>G	uc001kqp.2	-	15	1672	c.1617T>C	c.(1615-1617)GCT>GCC	p.A539A		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	539					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		CCATGATTTCAGCATGCAAAG	0.413													G	101960490	G	G	101960490	2	3	236	1	0	0	0	0	0	0	0	1	3416	175	7	4		4	CHUK	10	101960490	Silent	SNP	A	TCGA-32-4209-01A-01D-1353-08	3804832	101960490	33574257	26	16733											
MYO7A	4647	broad.mit.edu	37	chr11	76901767	76901767	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caagtccaagaagccaatcaTgttgcccgtgacattcatgg	9	11	2	2			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr11:76901767T>C	uc001oyb.2	+	30	4048	c.3776T>C	c.(3775-3777)ATG>ACG	p.M1259T	MYO7A_uc010rsm.1_Missense_Mutation_p.M1248T|MYO7A_uc001oyc.2_Missense_Mutation_p.M1259T|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Missense_Mutation_p.M470T	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1259	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						AAGCCAATCATGTTGCCCGTG	0.597													C	76901767	C	C	76901767	3	2	236	1	0	0	0	0	1	0	0	0	10082	1464	51	4	3924	4	MYO7A	11	76901767	Missense_Mutation	SNP	T	TCGA-32-4209-01A-01D-1353-08		76901767	58104749	27	16734											
C12orf35	55196	broad.mit.edu	37	chr12	32135884	32135884	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggaatgcctgctaaaagtgaCagtagctgttccatggaagt	12	7	0	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr12:32135884C>G	uc001rks.2	+	4	2409	c.1995C>G	c.(1993-1995)GAC>GAG	p.D665E		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	665										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CTAAAAGTGACAGTAGCTGTT	0.423													G	32135884	G	G	32135884	3	3	236	1	0	0	0	0	1	0	0	0	1682	477	17	5	1997	5	C12orf35	12	32135884	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08		32135884	101716011	28	16735											
ABCD2	225	broad.mit.edu	37	chr12	40013182	40013182	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tgaagaaatctgcattcactCcaggcgaaggtttttcacaa	8	9	3	2			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr12:40013182C>G	uc001rmb.2	-	1	662	c.236G>C	c.(235-237)GGA>GCA	p.G79A		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	79	Interaction with PEX19.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						TGCATTCACTCCAGGCGAAGG	0.463													G	40013182	G	G	40013182	3	3	236	1	0	0	0	0	1	0	0	0	61	855	30	5	2026	5	ABCD2	12	40013182	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	7877298	40013182	93838713	29	16736											
OR6C2	341416	broad.mit.edu	37	chr12	55846834	55846834	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcagttcttactacttctgtCgcacccttgttgaacccctt	5	14	3	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr12:55846834C>T	uc001sgz.1	+	1	837	c.837C>T	c.(835-837)GTC>GTT	p.V279V		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	279	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CTACTTCTGTCGCACCCTTGT	0.408													T	55846834	T	T	55846834	2	4	236	1	0	0	0	0	0	0	0	1	11191	871	31	2		2	OR6C2	12	55846834	Silent	SNP	C	TCGA-32-4209-01A-01D-1353-08	15833652	55846834	78005061	30	16737											
LEMD3	23592	broad.mit.edu	37	chr12	65637180	65637180	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttgtagcatttcatttagAtagaagaaattcaccaccaa	5	7	2	3			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr12:65637180A>G	uc001ssl.1	+	10	2324	c.2318A>G	c.(2317-2319)GAT>GGT	p.D773G	LEMD3_uc009zqo.1_Missense_Mutation_p.D772G	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	773	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		TTTCATTTAGATAGAAGAAAT	0.279													G	65637180	G	G	65637180	3	3	236	1	0	0	0	0	1	0	0	0	8721	333	12	4	2356	4	LEMD3	12	65637180	Missense_Mutation	SNP	A	TCGA-32-4209-01A-01D-1353-08	9790346	65637180	68214715	31	16738											
IKBIP	121457	broad.mit.edu	37	chr12	99007867	99007867	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attacatcagttactaaaccTgaaatccgtcgtatatctgt	5	9	2	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr12:99007867T>C	uc001tfv.2	-	3	659	c.549A>G	c.(547-549)TCA>TCG	p.S183S	IKBIP_uc001tfw.2_3'UTR	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	183					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TTACTAAACCTGAAATCCGTC	0.308													C	99007867	C	C	99007867	2	2	236	1	0	0	0	0	0	0	0	1	7609	1567	55	4		4	IKBIP	12	99007867	Silent	SNP	T	TCGA-32-4209-01A-01D-1353-08	33370687	99007867	34844028	32	16739											
MMP14	4323	broad.mit.edu	37	chr14	23312494	23312494	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcttcctggtggctgtgcaCgagctgggccatgccctggg	15	12	1	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr14:23312494C>T	uc001whc.2	+	5	951	c.717C>T	c.(715-717)CAC>CAT	p.H239H		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	239	Extracellular (Potential).	Zinc; catalytic.				extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TGGCTGTGCACGAGCTGGGCC	0.602													T	23312494	T	T	23312494	2	4	236	1	0	0	0	0	0	0	0	1	9653	535	19	1		1	MMP14	14	23312494	Silent	SNP	C	TCGA-32-4209-01A-01D-1353-08		23312494	84037046	33	16740											
TMC7	79905	broad.mit.edu	37	chr16	19073157	19073157	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cagaagcccaaagggacatgAggaactaactagactgagcg	12	9	0	4			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr16:19073157A>T	uc002dfq.2	+	16	2294	c.2164A>T	c.(2164-2166)AGG>TGG	p.R722W	TMC7_uc010vap.1_Missense_Mutation_p.R612W	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	722	Cytoplasmic (Potential).					integral to membrane				skin(2)|ovary(1)	3						AAGGGACATGAGGAACTAACT	0.418													T	19073157	T	T	19073157	3	4	236	1	0	0	0	0	1	0	0	0	15987	295	11	5	2226	5	TMC7	16	19073157	Missense_Mutation	SNP	A	TCGA-32-4209-01A-01D-1353-08		19073157	71281596	34	16741											
ULK2	9706	broad.mit.edu	37	chr17	19699577	19699577	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agatgcttgagttttagggaTtttgaaaggagctgtggtct	14	3	1	3			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr17:19699577T>G	uc002gwm.3	-	19	2337	c.1828A>C	c.(1828-1830)ATC>CTC	p.I610L	ULK2_uc002gwn.2_Missense_Mutation_p.I610L	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	610					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GTTTTAGGGATTTTGAAAGGA	0.413													G	19699577	G	G	19699577	3	3	236	1	0	0	0	0	1	0	0	0	16973	1493	52	5	1318	5	ULK2	17	19699577	Missense_Mutation	SNP	T	TCGA-32-4209-01A-01D-1353-08		19699577	61495633	35	16742											
CNTNAP1	8506	broad.mit.edu	37	chr17	40847561	40847561	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attggtggtttctttgagccGggcacctggatgcgctataa	13	8	1	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr17:40847561G>A	uc002iay.2	+	19	3231	c.3015G>A	c.(3013-3015)CCG>CCA	p.P1005P	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	1005	Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		TCTTTGAGCCGGGCACCTGGA	0.567													A	40847561	A	A	40847561	2	1	236	1	0	0	0	0	0	0	0	1	3646	1103	39	2		2	CNTNAP1	17	40847561	Silent	SNP	G	TCGA-32-4209-01A-01D-1353-08	21147984	40847561	40347649	36	16743											
TBCD	6904	broad.mit.edu	37	chr17	80842049	80842049	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgattgctgcggtgtttgacCgagacataaactgcagaaga	12	7	0	5			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr17:80842049C>T	uc002kfz.2	+	15	1634	c.1504C>T	c.(1504-1506)CGA>TGA	p.R502*	TBCD_uc002kfx.1_Nonsense_Mutation_p.R485*|TBCD_uc002kfy.1_Nonsense_Mutation_p.R502*	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	502					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GGTGTTTGACCGAGACATAAA	0.443													T	80842049	T	T	80842049	4	4	236	1	0	0	0	0	0	1	0	0	15630	644	23	2	1562	2	TBCD	17	80842049	Nonsense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	39994488	80842049	353161	37	16744											
ZNF492	57615	broad.mit.edu	37	chr19	22846757	22846757	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atgagtgtaaggtgcacaaaGaatgttacaatggacttaac	10	5	0	2	rs112130958		TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr19:22846757G>T	uc002nqw.3	+	4	530	c.286G>T	c.(286-288)GAA>TAA	p.E96*		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				GGTGCACAAAGAATGTTACAA	0.299													T	22846757	T	T	22846757	4	4	236	1	0	0	0	0	0	1	0	0	17940	943	33	5	296	5	ZNF492	19	22846757	Nonsense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08		22846757	36282226	38	16745											
CEACAM5	1048	broad.mit.edu	37	chr19	42224052	42224052	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaatgtcacaagaaatgacGcaagagcctatgtatgtgga	10	7	2	3	rs138799075	byFrequency	TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr19:42224052G>A	uc002ork.2	+	7	1817	c.1696G>A	c.(1696-1698)GCA>ACA	p.A566T	CEACAM5_uc002orj.1_Missense_Mutation_p.A565T|CEACAM5_uc002orl.2_Missense_Mutation_p.A566T	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	566	Ig-like 6.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		AAGAAATGACGCAAGAGCCTA	0.522													A	42224052	A	A	42224052	3	1	236	1	0	0	0	0	1	0	0	0	3195	1087	38	1	1722	1	CEACAM5	19	42224052	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08	19377295	42224052	16904931	39	16746											
KLK11	11012	broad.mit.edu	37	chr19	51528895	51528895	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcagaatcctcatggcctggAggggggaggagcgggcccca	18	11	1	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr19:51528895A>G	uc002pvd.1	-	2	201	c.89T>C	c.(88-90)CTC>CCC	p.L30P	KLK11_uc002pvb.1_5'UTR|KLK11_uc002pve.1_5'UTR|KLK11_uc002pvf.1_5'UTR|KLK11_uc002pvc.3_5'UTR|KLK11_uc010eom.2_5'UTR	NM_144947	NP_659196	Q9UBX7	KLK11_HUMAN	kallikrein 11 isoform 2 precursor	30					proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|GBM - Glioblastoma multiforme(134;0.00878)		CATGGCCTGGAGGGGGGAGGA	0.627													G	51528895	G	G	51528895	3	3	236	1	0	0	0	0	1	0	0	0	8399	304	11	4	854	4	KLK11	19	51528895	Missense_Mutation	SNP	A	TCGA-32-4209-01A-01D-1353-08	9304843	51528895	7600088	40	16747											
LILRB2	10288	broad.mit.edu	37	chr19	54783717	54783717	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtaatactgacagccatatCgccctgtgtgttcccaggtg	10	11	0	1	rs145209585	byFrequency	TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr19:54783717C>T	uc002qfb.2	-	4	550	c.284G>A	c.(283-285)CGA>CAA	p.R95Q	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.R95Q|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.R95Q|LILRB2_uc010yet.1_5'UTR|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	95	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACAGCCATATCGCCCTGTGTG	0.557													T	54783717	T	T	54783717	3	4	236	1	0	0	0	0	1	0	0	0	8791	884	31	2	1556	2	LILRB2	19	54783717	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	3254822	54783717	4345266	41	16748											
SIRPG	55423	broad.mit.edu	37	chr20	1629729	1629729	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atctcagtgcctggtccagaCttaaactccacgttctcagg	8	13	2	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr20:1629729C>A	uc002wfm.1	-	2	464	c.399G>T	c.(397-399)AAG>AAT	p.K133N	SIRPG_uc002wfn.1_Missense_Mutation_p.K133N|SIRPG_uc002wfo.1_Missense_Mutation_p.K133N	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	133	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						CTGGTCCAGACTTAAACTCCA	0.493													A	1629729	A	A	1629729	3	1	236	1	0	0	0	0	1	0	0	0	14336	564	20	5	780	5	SIRPG	20	1629729	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08		1629729	61395791	42	16749											
SIGLEC1	6614	broad.mit.edu	37	chr20	3673751	3673751	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgccatggctctccaggaggTaggtcaggcgcaggttgcgg	17	11	2	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr20:3673751T>C	uc002wja.2	-	14	3536	c.3536A>G	c.(3535-3537)TAC>TGC	p.Y1179C	SIGLEC1_uc002wjb.1_5'UTR|SIGLEC1_uc002wiz.3_Missense_Mutation_p.Y1179C	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1179	Ig-like C2-type 12.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CTCCAGGAGGTAGGTCAGGCG	0.682													C	3673751	C	C	3673751	3	2	236	1	0	0	0	0	1	0	0	0	14305	1638	57	4	1625	4	SIGLEC1	20	3673751	Missense_Mutation	SNP	T	TCGA-32-4209-01A-01D-1353-08	2044022	3673751	59351769	43	16750											
NTSR1	4923	broad.mit.edu	37	chr20	61340984	61340984	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcggcgacgccggctgccGcggctactacttcctgcgcg	13	17	0	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr20:61340984G>A	uc002ydf.2	+	1	796	c.425G>A	c.(424-426)CGC>CAC	p.R142H		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	142	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			GCCGGCTGCCGCGGCTACTAC	0.677													A	61340984	A	A	61340984	3	1	236	1	0	0	0	0	1	0	0	0	10710	1087	38	1	427	1	NTSR1	20	61340984	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08	57667233	61340984	1684536	44	16751											
TBX1	6899	broad.mit.edu	37	chr22	19748718	19748718	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaagaacgcgaaggtggccGgtgtgagcgtgcagctagag	18	7	0	4			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr22:19748718G>T	uc002zqb.2	+	3	454	c.325G>T	c.(325-327)GGT>TGT	p.G109C	TBX1_uc002zqa.1_Missense_Mutation_p.G109C|TBX1_uc002zqc.2_Missense_Mutation_p.G109C	NM_080646	NP_542377	O43435	TBX1_HUMAN	T-box 1 isoform A	109					embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)	2	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				GAAGGTGGCCGGTGTGAGCGT	0.592													T	19748718	T	T	19748718	3	4	236	1	0	0	0	0	1	0	0	0	15647	1116	39	5	331	5	TBX1	22	19748718	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08		19748718	31555848	45	16752											
LZTR1	8216	broad.mit.edu	37	chr22	21341825	21341825	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggaccccaccggccccccGttaccaccactcggccgtcg	10	21	0	0			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr22:21341825G>A	uc002zto.2	+	4	456	c.353G>A	c.(352-354)CGT>CAT	p.R118H	LZTR1_uc002ztn.2_Missense_Mutation_p.R77H|LZTR1_uc011ahy.1_Missense_Mutation_p.R99H|LZTR1_uc010gsr.1_5'UTR	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	118	Kelch 1.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CCGGCCCCCCGTTACCACCAC	0.662													A	21341825	A	A	21341825	3	1	236	1	0	0	0	0	1	0	0	0	9137	1145	40	1	367	1	LZTR1	22	21341825	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08	1593107	21341825	29962741	46	16753											
TFIP11	24144	broad.mit.edu	37	chr22	26890269	26890269	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tactgagccaagagcacagcAcctgccaaaaagaaaaatta	7	10	0	3			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr22:26890269A>C	uc003acr.2	-	13	2368	c.1994T>G	c.(1993-1995)GTG>GGG	p.V665G	TFIP11_uc003acq.2_Missense_Mutation_p.V24G|TFIP11_uc003acs.2_Missense_Mutation_p.V665G|TFIP11_uc003act.2_Missense_Mutation_p.V665G|uc003acu.1_RNA	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	665					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						AGAGCACAGCACCTGCCAAAA	0.463													C	26890269	C	C	26890269	3	2	236	1	0	0	0	0	1	0	0	0	15804	173	6	5	527	5	TFIP11	22	26890269	Missense_Mutation	SNP	A	TCGA-32-4209-01A-01D-1353-08	5548444	26890269	24414297	47	16754											
NEFH	4744	broad.mit.edu	37	chr22	29886360	29886360	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ccaccccagagaaggaggctCctgccaaggtggaggtgaag	15	11	0	2			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr22:29886360C>A	uc003afo.2	+	4	2802	c.2731C>A	c.(2731-2733)CCT>ACT	p.P911T	NEFH_uc003afp.2_5'UTR	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	917	Tail.				cell death|nervous system development	neurofilament					0						GAAGGAGGCTCCTGCCAAGGT	0.502													A	29886360	A	A	29886360	3	1	236	1	0	0	0	0	1	0	0	0	10314	855	30	5	2745	5	NEFH	22	29886360	Missense_Mutation	SNP	C	TCGA-32-4209-01A-01D-1353-08	2996091	29886360	21418206	48	16755											
DEPDC5	9681	broad.mit.edu	37	chr22	32275577	32275577	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgacttcgccagcttccagcGcaagtggtttgaggtggcct	13	12	0	1			TCGA-32-4209-01A-01D-1353-08	TCGA-32-4209-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	0c30ef40-b943-4281-84d7-8d574882abd4	77169aad-6bd8-4b1b-bb48-c02960d41ea0	g.chr22:32275577G>A	uc003als.2	+	37	3921	c.3779G>A	c.(3778-3780)CGC>CAC	p.R1260H	DEPDC5_uc011als.1_Missense_Mutation_p.R1191H|DEPDC5_uc011alu.1_Missense_Mutation_p.R1291H|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.R1282H|DEPDC5_uc003alu.2_Missense_Mutation_p.R709H|DEPDC5_uc003alv.2_RNA|DEPDC5_uc003alw.2_Missense_Mutation_p.R558H|DEPDC5_uc011alx.1_Missense_Mutation_p.R108H|DEPDC5_uc010gwk.2_Missense_Mutation_p.R286H|DEPDC5_uc011aly.1_Missense_Mutation_p.R108H	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1260					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						AGCTTCCAGCGCAAGTGGTTT	0.607													A	32275577	A	A	32275577	3	1	236	1	0	0	0	0	1	0	0	0	4442	1087	38	1	4009	1	DEPDC5	22	32275577	Missense_Mutation	SNP	G	TCGA-32-4209-01A-01D-1353-08	2389217	32275577	19028989	49	16756											
PRAMEF10	343071	broad.mit.edu	37	chr1	12955489	12955489	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcagggatcccagagggaGgctgaggaagggccaggcct	17	10	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr1:12955489G>A	uc001auo.2	-	2	263	c.190C>T	c.(190-192)CTC>TTC	p.L64F		NM_001039361	NP_001034450	O60809	PRA10_HUMAN	PRAME family member 10	64											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCCAGAGGGAGGCTGAGGAAG	0.587													A	12955489	A	A	12955489	3	1	237	1	0	0	0	0	1	0	0	0	12426	1000	35	3	1246	3	PRAMEF10	1	12955489	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08		12955489	236295132	1	16757											
CASP9	842	broad.mit.edu	37	chr1	15844698	15844698	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aatctctggtctgagcaccaCtggggtaaggttttctaggg	13	8	3	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr1:15844698C>A	uc001awn.2	-	2	420	c.325G>T	c.(325-327)GTG>TTG	p.V109L	CASP9_uc001awm.1_Missense_Mutation_p.V109L|CASP9_uc001awo.2_Missense_Mutation_p.V109L|CASP9_uc001awp.2_5'UTR|CASP9_uc009voi.2_Intron|CASP9_uc010obm.1_Missense_Mutation_p.V26L|CASP9_uc001awq.2_Missense_Mutation_p.V26L	NM_001229	NP_001220	P55211	CASP9_HUMAN	caspase 9 isoform alpha preproprotein	109					activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(1)|kidney(1)	2		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		CTGAGCACCACTGGGGTAAGG	0.517													A	15844698	A	A	15844698	3	1	237	1	0	0	0	0	1	0	0	0	2679	565	20	5	957	5	CASP9	1	15844698	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	2889209	15844698	233405923	2	16758											
MYOM3	127294	broad.mit.edu	37	chr1	24409117	24409117	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accctgatgggctcggtggcGgctgagctctcgcctacccc	13	16	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr1:24409117G>A	uc001bin.3	-	17	2221	c.2058C>T	c.(2056-2058)GCC>GCT	p.A686A	MYOM3_uc001bim.3_Silent_p.A343A|MYOM3_uc001bio.2_Silent_p.A686A|MYOM3_uc001bip.1_3'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	686	Fibronectin type-III 3.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCTCGGTGGCGGCTGAGCTCT	0.622													A	24409117	A	A	24409117	2	1	237	1	0	0	0	0	0	0	0	1	10093	1103	39	2		2	MYOM3	1	24409117	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	8564419	24409117	224841504	3	16759											
C8B	732	broad.mit.edu	37	chr1	57425758	57425758	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agacagctcacaatcaatggGcatcagggtaacatccacac	8	12	3	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr1:57425758G>A	uc001cyp.2	-	2	251	c.184C>T	c.(184-186)CCC>TCC	p.P62S	C8B_uc010oon.1_5'UTR|C8B_uc010ooo.1_Missense_Mutation_p.P10S	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	62					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						CAATCAATGGGCATCAGGGTA	0.498													A	57425758	A	A	57425758	3	1	237	1	0	0	0	0	1	0	0	0	2417	1203	42	3	1635	3	C8B	1	57425758	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	33016641	57425758	191824863	4	16760											
DEPDC1	55635	broad.mit.edu	37	chr1	68948414	68948414	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtagtctctcagtagaatcTgattcttctttgtttttttc	6	7	5	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr1:68948414T>C	uc001dem.3	-	8	1194	c.1077A>G	c.(1075-1077)TCA>TCG	p.S359S	DEPDC1_uc001dej.3_5'Flank|DEPDC1_uc001dek.3_RNA|DEPDC1_uc001del.3_Intron	NM_001114120	NP_001107592	Q5TB30	DEP1A_HUMAN	DEP domain containing 1 isoform a	359					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		CAGTAGAATCTGATTCTTCTT	0.343													C	68948414	C	C	68948414	2	2	237	1	0	0	0	0	0	0	0	1	4439	1567	55	4		4	DEPDC1	1	68948414	Silent	SNP	T	TCGA-32-4210-01A-01D-1353-08	11522656	68948414	180302207	5	16761											
MAGI3	260425	broad.mit.edu	37	chr1	114225544	114225544	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggatattaataatccttcGtcttcaaatgtgatttatga	7	5	2	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr1:114225544G>A	uc001edk.2	+	21	3535	c.3354G>A	c.(3352-3354)TCG>TCA	p.S1118S	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1143					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAATCCTTCGTCTTCAAATG	0.318													A	114225544	A	A	114225544	2	1	237	1	0	0	0	0	0	0	0	1	9192	1132	40	1		1	MAGI3	1	114225544	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	45277130	114225544	135025077	6	16762											
AQP10	89872	broad.mit.edu	37	chr1	154296100	154296100	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atgctgattgtggggctcttGgccatcctggacagacggaa	14	9	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr1:154296100G>C	uc001feu.2	+	5	565	c.525G>C	c.(523-525)TTG>TTC	p.L175F	AQP10_uc001fev.2_Missense_Mutation_p.L175F|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	175	Helical; (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGGGGCTCTTGGCCATCCTGG	0.607													C	154296100	C	C	154296100	3	2	237	1	0	0	0	0	1	0	0	0	822	1339	47	5	543	5	AQP10	1	154296100	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	40070556	154296100	94954521	7	16763											
MPZL1	9019	broad.mit.edu	37	chr1	167734984	167734984	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agggggccgacactactgtgTcggtaagaatgcttgacttc	13	9	0	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr1:167734984T>G	uc001geo.2	+	2	458	c.256T>G	c.(256-258)TCG>GCG	p.S86A	MPZL1_uc001gen.3_Missense_Mutation_p.S86A|MPZL1_uc001gep.2_Missense_Mutation_p.S86A|MPZL1_uc001geq.2_Missense_Mutation_p.S86A|MPZL1_uc009wvh.2_RNA	NM_003953	NP_003944	O95297	MPZL1_HUMAN	myelin protein zero-like 1 isoform a	86	Extracellular (Potential).|Ig-like V-type.				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			ovary(2)	2	all_hematologic(923;0.215)					CACTACTGTGTCGGTAAGAAT	0.483													G	167734984	G	G	167734984	3	3	237	1	0	0	0	0	1	0	0	0	9749	1667	58	5	262	5	MPZL1	1	167734984	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	13438884	167734984	81515637	8	16764											
JMJD4	65094	broad.mit.edu	37	chr1	227922480	227922480	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttggggttcgagttgtattcCtggaccccacagtttgcaac	11	10	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr1:227922480C>A	uc001hrb.2	-	2	438	c.438G>T	c.(436-438)CAG>CAT	p.Q146H	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|JMJD4_uc001hrc.2_Missense_Mutation_p.Q146H	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	146											0		Prostate(94;0.0885)				AGTTGTATTCCTGGACCCCAC	0.552													A	227922480	A	A	227922480	3	1	237	1	0	0	0	0	1	0	0	0	7951	680	24	5	973	5	JMJD4	1	227922480	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	60187496	227922480	21328141	9	16765											
CAD	790	broad.mit.edu	37	chr2	27449783	27449783	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcctcgatgggaccttagcaAgttcctgcgagtcagcacaa	10	12	1	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr2:27449783A>G	uc002rji.2	+	15	2402	c.2240A>G	c.(2239-2241)AAG>AGG	p.K747R	CAD_uc010eyw.2_Missense_Mutation_p.K684R	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	747	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GACCTTAGCAAGTTCCTGCGA	0.562													G	27449783	G	G	27449783	3	3	237	1	0	0	0	0	1	0	0	0	2565	72	3	4	2298	4	CAD	2	27449783	Missense_Mutation	SNP	A	TCGA-32-4210-01A-01D-1353-08		27449783	215749590	10	16766											
DPP10	57628	broad.mit.edu	37	chr2	116548668	116548668	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggtttacagaatattttataTtggaaagcaattctatgctg	8	4	1	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr2:116548668T>A	uc002tla.1	+	18	2000	c.1543T>A	c.(1543-1545)TTG>ATG	p.L515M	DPP10_uc002tlb.1_Missense_Mutation_p.L465M|DPP10_uc002tlc.1_Missense_Mutation_p.L511M|DPP10_uc002tle.2_Missense_Mutation_p.L519M|DPP10_uc002tlf.1_Missense_Mutation_p.L508M	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	515	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ATATTTTATATTGGAAAGCAA	0.303													A	116548668	A	A	116548668	3	1	237	1	0	0	0	0	1	0	0	0	4727	1490	52	5	1784	5	DPP10	2	116548668	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	89098885	116548668	126650705	11	16767											
YSK4	80122	broad.mit.edu	37	chr2	135744775	135744775	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taggcttaatgggaccttcaGtagaaatcacaaaattctga	8	7	3	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr2:135744775G>A	uc002tue.1	-	7	1698	c.1667C>T	c.(1666-1668)ACT>ATT	p.T556I	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.T443I|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.T284I|YSK4_uc002tui.3_Missense_Mutation_p.T573I	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	556							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GGGACCTTCAGTAGAAATCAC	0.428													A	135744775	A	A	135744775	3	1	237	1	0	0	0	0	1	0	0	0	17492	1029	36	3	2335	3	YSK4	2	135744775	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	19196107	135744775	107454598	12	16768											
FAP	2191	broad.mit.edu	37	chr2	163055364	163055365	+	Missense_Mutation	DNP	GC	AA	AA													tggcaagtaacacacttcttGcttggaggatagcttccaat							TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr2:163055364_163055365GC>AA	uc002ucd.2	-	16	1512_1513	c.1304_1305GC>TT	c.(1303-1305)AGC>ATT	p.S435I	FAP_uc010fpc.2_5'UTR|FAP_uc010zct.1_Missense_Mutation_p.S410I|FAP_uc010fpd.2_5'UTR	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	435	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						CACACTTCTTGCTTGGAGGATA	0.371													AA	163055365	AA	AA	163055364	3	1	237	1	0	0	0	0	1	0	0	0	5673	1310	46	3	1021	3	FAP	2	163055364	Missense_Mutation	DNP	GC	TCGA-32-4210-01A-01D-1353-08	27310589	163055364	80144009	13	16769											
TTN	7273	broad.mit.edu	37	chr2	179421857	179421857	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaaatatcagtgatacgaaCatttcttgggggttctgtgg	12	5	3	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr2:179421857C>T	uc010zfg.1	-	279	80544	c.80320G>A	c.(80320-80322)GTT>ATT	p.V26774I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V20469I|TTN_uc010zfi.1_Missense_Mutation_p.V20402I|TTN_uc010zfj.1_Missense_Mutation_p.V20277I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27701							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGATACGAACATTTCTTGGG	0.403													T	179421857	T	T	179421857	3	4	237	1	0	0	0	0	1	0	0	0	16732	478	17	3	20087	3	TTN	2	179421857	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	16366493	179421857	63777516	14	16770											
TTN	7273	broad.mit.edu	37	chr2	179483569	179483569	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtcttggtcagctgtcttgaTttttggtgcagctagtgaga	13	6	3	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr2:179483569T>A	uc010zfg.1	-	200	39228	c.39004A>T	c.(39004-39006)ATC>TTC	p.I13002F	TTN_uc010zfh.1_Missense_Mutation_p.I6697F|TTN_uc010zfi.1_Missense_Mutation_p.I6630F|TTN_uc010zfj.1_Missense_Mutation_p.I6505F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13929							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTCTTGATTTTTGGTGCA	0.408													A	179483569	A	A	179483569	3	1	237	1	0	0	0	0	1	0	0	0	16732	1493	52	5	61433	5	TTN	2	179483569	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	61712	179483569	63715804	15	16771											
TTN	7273	broad.mit.edu	37	chr2	179485012	179485012	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctttctctctggagagctgGcaggagaagacagcgtcatc	13	10	3	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr2:179485012G>A	uc010zfg.1	-	197	38756	c.38532C>T	c.(38530-38532)TGC>TGT	p.C12844C	TTN_uc010zfh.1_Silent_p.C6539C|TTN_uc010zfi.1_Silent_p.C6472C|TTN_uc010zfj.1_Silent_p.C6347C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13771							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGAGAGCTGGCAGGAGAAGA	0.418													A	179485012	A	A	179485012	2	1	237	1	0	0	0	0	0	0	0	1	16732	1195	42	3		3	TTN	2	179485012	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	1443	179485012	63714361	16	16772											
FGD5	152273	broad.mit.edu	37	chr3	14861995	14861995	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagggtggcctggttcccGcggacaggaagaacaccagc	15	12	0	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr3:14861995G>A	uc003bzc.2	+	1	1527	c.1417G>A	c.(1417-1419)GCG>ACG	p.A473T	FGD5_uc011avk.1_Missense_Mutation_p.A473T	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	473					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CCTGGTTCCCGCGGACAGGAA	0.642													A	14861995	A	A	14861995	3	1	237	1	0	0	0	0	1	0	0	0	5836	1087	38	1	1419	1	FGD5	3	14861995	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08		14861995	183160435	17	16773											
ZBED2	79413	broad.mit.edu	37	chr3	111312849	111312849	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttgggatggtgcccagcaCgagcaggagctaggtggaaa	18	7	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr3:111312849C>T	uc003dxy.2	-	2	1085	c.200G>A	c.(199-201)CGT>CAT	p.R67H	CD96_uc003dxv.2_Intron|CD96_uc003dxw.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_024508	NP_078784	Q9BTP6	ZBED2_HUMAN	zinc finger, BED domain containing 2	67	BED-type.						DNA binding|metal ion binding			skin(1)	1						GTGCCCAGCACGAGCAGGAGC	0.612													T	111312849	T	T	111312849	3	4	237	1	0	0	0	0	1	0	0	0	17515	536	19	1	460	1	ZBED2	3	111312849	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	96450854	111312849	86709581	18	16774											
MFI2	4241	broad.mit.edu	37	chr3	196735736	196735736	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctgttgcccacacacttgttGcggccctgctcgtcccccac	8	19	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr3:196735736G>C	uc003fxk.3	-	12	1739	c.1626C>G	c.(1624-1626)CGC>CGG	p.R542R		NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	542	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CACACTTGTTGCGGCCCTGCT	0.642													C	196735736	C	C	196735736	2	2	237	1	0	0	0	0	0	0	0	1	9522	1306	46	5		5	MFI2	3	196735736	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	85422887	196735736	1286694	19	16775											
ARAP2	116984	broad.mit.edu	37	chr4	36231022	36231022	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttcacagtagtaaaaccagaCtcatggaaatgtaagagata	8	6	2	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr4:36231022C>G	uc003gsq.1	-	2	425	c.87G>C	c.(85-87)GAG>GAC	p.E29D	ARAP2_uc003gsr.1_Missense_Mutation_p.E29D	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	29	SAM.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TAAAACCAGACTCATGGAAAT	0.393													G	36231022	G	G	36231022	3	3	237	1	0	0	0	0	1	0	0	0	839	564	20	5	5155	5	ARAP2	4	36231022	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08		36231022	154923254	20	16776											
RBM47	54502	broad.mit.edu	37	chr4	40440160	40440160	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtctcgatcatgaggttgcGcacgtagaggatcttcacgg	14	9	4	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr4:40440160G>A	uc003gvc.2	-	4	1461	c.751C>T	c.(751-753)CGC>TGC	p.R251C	RBM47_uc003gvd.2_Missense_Mutation_p.R251C|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.R213C|RBM47_uc003gvg.1_Missense_Mutation_p.R251C	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	251	RRM 3.					nucleus	nucleotide binding|RNA binding			breast(3)	3						ATGAGGTTGCGCACGTAGAGG	0.617													A	40440160	A	A	40440160	3	1	237	1	0	0	0	0	1	0	0	0	13141	1087	38	1	1046	1	RBM47	4	40440160	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	4209138	40440160	150714116	21	16777											
UBA6	55236	broad.mit.edu	37	chr4	68543331	68543331	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acaaaatggagtactaacctGgtatttatctaaaaaggaga	8	5	1	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr4:68543331G>T	uc003hdg.3	-	6	515	c.463C>A	c.(463-465)CAG>AAG	p.Q155K	UBA6_uc003hdi.2_Missense_Mutation_p.Q155K|UBA6_uc003hdj.2_Missense_Mutation_p.Q155K	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	155					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						GTACTAACCTGGTATTTATCT	0.308													T	68543331	T	T	68543331	3	4	237	1	0	0	0	0	1	0	0	0	16829	1357	47	5	2807	5	UBA6	4	68543331	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	28103171	68543331	122610945	22	16778											
PTPN13	5783	broad.mit.edu	37	chr4	87671855	87671855	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gacaaagcttcatgggaggaAaagcctagagagatgagtaa	13	5	1	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr4:87671855A>G	uc003hpz.2	+	18	3363	c.2883A>G	c.(2881-2883)GAA>GAG	p.E961E	PTPN13_uc003hpy.2_Silent_p.E961E|PTPN13_uc003hqa.2_Silent_p.E961E|PTPN13_uc003hqb.2_Intron	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	961						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CATGGGAGGAAAAGCCTAGAG	0.438													G	87671855	G	G	87671855	2	3	237	1	0	0	0	0	0	0	0	1	12782	11	1	4		4	PTPN13	4	87671855	Silent	SNP	A	TCGA-32-4210-01A-01D-1353-08	19128524	87671855	103482421	23	16779											
CCNA2	890	broad.mit.edu	37	chr4	122744710	122744710	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcctggtcctcttggagcGccgtctgctgcaatgctagc	11	14	3	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr4:122744710G>A	uc003iec.3	-	1	379	c.74C>T	c.(73-75)GCG>GTG	p.A25V		NM_001237	NP_001228	P20248	CCNA2_HUMAN	cyclin A	25					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1						CTCTTGGAGCGCCGTCTGCTG	0.692													A	122744710	A	A	122744710	3	1	237	1	0	0	0	0	1	0	0	0	2910	1087	38	1	1256	1	CCNA2	4	122744710	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	35072855	122744710	68409566	24	16780											
SMARCA5	8467	broad.mit.edu	37	chr4	144461639	144461639	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcagactggattcaatagtcAttcaacaaggtaagccatgg	9	8	4	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr4:144461639A>T	uc003ijg.2	+	14	2356	c.1894A>T	c.(1894-1896)ATT>TTT	p.I632F		NM_003601	NP_003592	O60264	SMCA5_HUMAN	SWI/SNF-related matrix-associated	632	Helicase C-terminal.				CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)					TTCAATAGTCATTCAACAAGG	0.363													T	144461639	T	T	144461639	3	4	237	1	0	0	0	0	1	0	0	0	14771	217	8	5	1948	5	SMARCA5	4	144461639	Missense_Mutation	SNP	A	TCGA-32-4210-01A-01D-1353-08	21716929	144461639	46692637	25	16781											
C4orf45	152940	broad.mit.edu	37	chr4	159881481	159881481	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tattgaatcaagagaagcttGacttagttcttcatactgta	7	6	3	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr4:159881481G>T	uc003iqf.1	-	3	398	c.313C>A	c.(313-315)CAA>AAA	p.Q105K	C4orf45_uc010iqt.1_Intron	NM_152543	NP_689756	Q96LM5	CD045_HUMAN	hypothetical protein LOC152940	105											0						AGAGAAGCTTGACTTAGTTCT	0.308													T	159881481	T	T	159881481	3	4	237	1	0	0	0	0	1	0	0	0	2273	1299	45	5	259	5	C4orf45	4	159881481	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	15419842	159881481	31272795	26	16782											
PLEKHG4B	153478	broad.mit.edu	37	chr5	140833	140833	+	Splice_Site	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggctgcaccaaagaggaaggTaaatgctccccacgccctcc	10	15	0	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr5:140833T>G	uc003jak.2	+	1	459	c.409_splice	c.e1+2	p.D137_splice		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AAGAGGAAGGTAAATGCTCCC	0.552													G	140833	G	G	140833	5	3	237	1	0	0	0	0	0	0	1	0	12072	1652	57	5	413	5	PLEKHG4B	5	140833	Splice_Site	SNP	T	TCGA-32-4210-01A-01D-1353-08		140833	180774427	27	16783											
CTNND2	1501	broad.mit.edu	37	chr5	11199757	11199757	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtccaccaggagctggatgCctccttgtctccttatctga	10	13	2	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr5:11199757C>T	uc003jfa.1	-	11	1923	c.1778G>A	c.(1777-1779)GGC>GAC	p.G593D	CTNND2_uc010itt.2_Missense_Mutation_p.G502D|CTNND2_uc011cmy.1_Missense_Mutation_p.G256D|CTNND2_uc011cmz.1_Missense_Mutation_p.G160D|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.G160D	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	593	ARM 3.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GAGCTGGATGCCTCCTTGTCT	0.473													T	11199757	T	T	11199757	3	4	237	1	0	0	0	0	1	0	0	0	4020	739	26	3	1947	3	CTNND2	5	11199757	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	11058924	11199757	169715503	28	16784											
PTGER4	5734	broad.mit.edu	37	chr5	40681332	40681332	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcccggtgaccatcgccacGtacatgaagggccaatggcc	12	14	0	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr5:40681332G>A	uc003jlz.2	+	2	829	c.237G>A	c.(235-237)ACG>ACA	p.T79T		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	79	Helical; Name=2; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						CCATCGCCACGTACATGAAGG	0.607											OREG0016588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	40681332	A	A	40681332	2	1	237	1	0	0	0	0	0	0	0	1	12745	1132	40	1		1	PTGER4	5	40681332	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	29481575	40681332	140233928	29	16785											
THBS4	7060	broad.mit.edu	37	chr5	79373950	79373950	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatcgacgtctgcccagagaAcgcagaggtcaccctgaccg	12	14	2	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr5:79373950A>G	uc003kgh.2	+	18	2488	c.2165A>G	c.(2164-2166)AAC>AGC	p.N722S	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	722	TSP type-3 8.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		TGCCCAGAGAACGCAGAGGTC	0.592													G	79373950	G	G	79373950	3	3	237	1	0	0	0	0	1	0	0	0	15853	43	2	4	2231	4	THBS4	5	79373950	Missense_Mutation	SNP	A	TCGA-32-4210-01A-01D-1353-08	38692618	79373950	101541310	30	16786											
GPR98	84059	broad.mit.edu	37	chr5	90021005	90021005	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gaaatgaagaaaagccttctCttaacagtgtgtttacattc	7	7	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr5:90021005C>A	uc003kju.2	+	47	10105	c.10009C>A	c.(10009-10011)CTT>ATT	p.L3337I	GPR98_uc003kjt.2_Missense_Mutation_p.L1043I|GPR98_uc003kjv.2_Missense_Mutation_p.L937I	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3337	Extracellular (Potential).|EAR 2.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAAGCCTTCTCTTAACAGTGT	0.264													A	90021005	A	A	90021005	3	1	237	1	0	0	0	0	1	0	0	0	6721	913	32	5	10195	5	GPR98	5	90021005	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	10647055	90021005	90894255	31	16787											
PCDHB1	29930	broad.mit.edu	37	chr5	140432384	140432384	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgatagaggtgctaatatcCgacgttaatgacaatcctcc	8	9	0	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr5:140432384C>T	uc003lik.1	+	1	1406	c.1329C>T	c.(1327-1329)TCC>TCT	p.S443S		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	443	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTAATATCCGACGTTAATG	0.448													T	140432384	T	T	140432384	2	4	237	1	0	0	0	0	0	0	0	1	11534	639	23	2		2	PCDHB1	5	140432384	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08	50411379	140432384	40482876	32	16788											
FAM71B	153745	broad.mit.edu	37	chr5	156589852	156589852	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttttttgtcatctctcgtgTttttatggccagatgcggac	9	9	2	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr5:156589852T>C	uc003lwn.2	-	2	1524	c.1424A>G	c.(1423-1425)AAC>AGC	p.N475S		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	475						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATCTCTCGTGTTTTTATGGCC	0.527													C	156589852	C	C	156589852	3	2	237	1	0	0	0	0	1	0	0	0	5608	1725	60	4	397	4	FAM71B	5	156589852	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	16157468	156589852	24325408	33	16789											
GABRA6	2559	broad.mit.edu	37	chr5	161128598	161128598	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caataaagtgctcacgagagCgcccatcttacaatcaacac	6	13	3	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr5:161128598C>T	uc003lyu.2	+	9	1519	c.1181C>T	c.(1180-1182)GCG>GTG	p.A394V	GABRA6_uc003lyv.2_Missense_Mutation_p.A165V	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	394	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTCACGAGAGCGCCCATCTTA	0.473										TCGA Ovarian(5;0.080)			T	161128598	T	T	161128598	3	4	237	1	0	0	0	0	1	0	0	0	6165	768	27	1	1215	1	GABRA6	5	161128598	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	4538746	161128598	19786662	34	16790											
MDC1	9656	broad.mit.edu	37	chr6	30675376	30675376	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cctggggctcactggggatcCccttccacctgactggctcc	11	17	1	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr6:30675376C>A	uc003nrg.3	-	8	3420	c.2980G>T	c.(2980-2982)GGA>TGA	p.G994*	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Intron	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	994				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						ACTGGGGATCCCCTTCCACCT	0.637								Other_conserved_DNA_damage_response_genes					A	30675376	A	A	30675376	4	1	237	1	0	0	0	0	0	1	0	0	9403	632	22	5	3321	5	MDC1	6	30675376	Nonsense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08		30675376	140439691	35	16791											
DST	667	broad.mit.edu	37	chr6	56476386	56476386	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcttggttgatatttcctcActggaaatctgtaaggtaaa	8	6	3	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr6:56476386A>G	uc003pdf.2	-	37	4996	c.4968T>C	c.(4966-4968)AGT>AGC	p.S1656S	DST_uc003pcz.3_Silent_p.S1478S|DST_uc011dxj.1_Silent_p.S1507S|DST_uc011dxk.1_Silent_p.S1518S|DST_uc003pcy.3_Silent_p.S1152S|DST_uc003pdb.2_Silent_p.S1152S	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATATTTCCTCACTGGAAATCT	0.333													G	56476386	G	G	56476386	2	3	237	1	0	0	0	0	0	0	0	1	4783	156	6	4		4	DST	6	56476386	Silent	SNP	A	TCGA-32-4210-01A-01D-1353-08	25801010	56476386	114638681	36	16792											
PTP4A1	7803	broad.mit.edu	37	chr6	64289185	64289185	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tccagtacttgttgccctagCattaattgaaggtggaatga	10	7	0	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr6:64289185C>A	uc003pek.2	+	7	1339	c.353C>A	c.(352-354)GCA>GAA	p.A118E	PTP4A1_uc003pel.2_Missense_Mutation_p.A118E	NM_003463	NP_003454	Q93096	TP4A1_HUMAN	protein tyrosine phosphatase type IVA, member 1	118	Tyrosine-protein phosphatase.|Interaction with ATF5 (By similarity).				cell cycle|multicellular organismal development	early endosome|endoplasmic reticulum|internal side of plasma membrane|spindle	protein binding|protein tyrosine phosphatase activity				0	all_cancers(3;0.071)|all_epithelial(2;0.0146)|Lung NSC(77;0.175)		Epithelial(2;0.0365)|LUSC - Lung squamous cell carcinoma(74;0.0644)|all cancers(2;0.112)|Lung(124;0.13)			GTTGCCCTAGCATTAATTGAA	0.328													A	64289185	A	A	64289185	3	1	237	1	0	0	0	0	1	0	0	0	12770	710	25	5	367	5	PTP4A1	6	64289185	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	7812799	64289185	106825882	37	16793											
C6orf182	285753	broad.mit.edu	37	chr6	109480497	109480497	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcaacatcgtgacccacataTccttcagaaaccttttaacg	5	13	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr6:109480497T>C	uc010kdk.2	+	11	1425	c.848T>C	c.(847-849)ATC>ACC	p.I283T	C6orf182_uc003psx.3_Missense_Mutation_p.I283T|C6orf182_uc010kdl.2_Missense_Mutation_p.I283T|C6orf182_uc003psy.3_Missense_Mutation_p.I283T	NM_001083535	NP_001077004	Q8IYX8	CE57L_HUMAN	hypothetical protein LOC285753	283						microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)		GACCCACATATCCTTCAGAAA	0.433													C	109480497	C	C	109480497	3	2	237	1	0	0	0	0	1	0	0	0	2346	1435	50	4	878	4	C6orf182	6	109480497	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	45191312	109480497	61634570	38	16794											
C6orf170	221322	broad.mit.edu	37	chr6	121433663	121433663	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agtcttacagaaatatgtagCcttggcaaccaaagaaaagc	8	8	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr6:121433663C>G	uc003pyo.1	-	29	3380	c.3312G>C	c.(3310-3312)AGG>AGC	p.R1104S		NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	1104					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		AAATATGTAGCCTTGGCAACC	0.338													G	121433663	G	G	121433663	3	3	237	1	0	0	0	0	1	0	0	0	2344	738	26	5	477	5	C6orf170	6	121433663	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	11953166	121433663	49681404	39	16795											
GRM1	2911	broad.mit.edu	37	chr6	146708084	146708084	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cacggcctgcaaagagaatgAatatgtgcaagatgagttca	11	7	1	4			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr6:146708084A>T	uc010khw.1	+	7	2131	c.1661A>T	c.(1660-1662)GAA>GTA	p.E554V	GRM1_uc010khv.1_Missense_Mutation_p.E554V|GRM1_uc003qll.2_Missense_Mutation_p.E554V|GRM1_uc011edz.1_Missense_Mutation_p.E554V|GRM1_uc011eea.1_Missense_Mutation_p.E554V	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	554	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AAAGAGAATGAATATGTGCAA	0.438													T	146708084	T	T	146708084	3	4	237	1	0	0	0	0	1	0	0	0	6796	246	9	5	1683	5	GRM1	6	146708084	Missense_Mutation	SNP	A	TCGA-32-4210-01A-01D-1353-08	25274421	146708084	24406983	40	16796											
PLEKHG1	57480	broad.mit.edu	37	chr6	151117039	151117039	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tattgcactaactatccaagGtatggatcgagaatgggcca	10	8	0	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr6:151117039G>T	uc003qny.1	+	6	941	c.629_splice	c.e6+1	p.R210_splice	PLEKHG1_uc011eel.1_Splice_Site_p.R250_splice|PLEKHG1_uc011eem.1_Splice_Site_p.R269_splice|PLEKHG1_uc003qnz.2_Splice_Site_p.R210_splice	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ACTATCCAAGGTATGGATCGA	0.403													T	151117039	T	T	151117039	5	4	237	1	0	0	0	0	0	0	1	0	12068	1275	44	5	644	5	PLEKHG1	6	151117039	Splice_Site	SNP	G	TCGA-32-4210-01A-01D-1353-08	4408955	151117039	19998028	41	16797											
SYNE1	23345	broad.mit.edu	37	chr6	152792795	152792795	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tacttaatgatccaagacttCagctttgactctgcaagaac	6	10	2	4			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr6:152792795C>T	uc010kiw.2	-	16	2171	c.1569G>A	c.(1567-1569)CTG>CTA	p.L523L	SYNE1_uc003qot.3_Silent_p.L530L|SYNE1_uc003qou.3_Silent_p.L523L|SYNE1_uc010kjb.1_Silent_p.L506L|SYNE1_uc003qpa.1_Silent_p.L523L|SYNE1_uc003qox.1_Silent_p.L39L|SYNE1_uc003qoz.2_5'UTR|SYNE1_uc003qoy.2_Silent_p.L90L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	523	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCCAAGACTTCAGCTTTGACT	0.438										HNSCC(10;0.0054)			T	152792795	T	T	152792795	2	4	237	1	0	0	0	0	0	0	0	1	15442	813	29	3		3	SYNE1	6	152792795	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08	1675756	152792795	18322272	42	16798											
SLC29A4	222962	broad.mit.edu	37	chr7	5330388	5330388	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgagccagtgcccgatgaCcgttatcacgccatctactt	9	14	2	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr7:5330388C>T	uc003sod.2	+	3	356	c.195C>T	c.(193-195)GAC>GAT	p.D65D	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Silent_p.D65D|SLC29A4_uc003soe.2_Silent_p.D65D	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	65	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		TGCCCGATGACCGTTATCACG	0.587													T	5330388	T	T	5330388	2	4	237	1	0	0	0	0	0	0	0	1	14537	506	18	3		3	SLC29A4	7	5330388	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08		5330388	153808275	43	16799											
CPVL	54504	broad.mit.edu	37	chr7	29134756	29134756	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggggaagtctctgtcacGcactgtgaaaacaaagaaga	11	9	2	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr7:29134756G>A	uc003szv.2	-	5	525	c.406C>T	c.(406-408)CGT>TGT	p.R136C	CPVL_uc003szw.2_Missense_Mutation_p.R136C|CPVL_uc003szx.2_Missense_Mutation_p.R136C	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	136					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						TCTCTGTCACGCACTGTGAAA	0.547													A	29134756	A	A	29134756	3	1	237	1	0	0	0	0	1	0	0	0	3835	1087	38	1	1060	1	CPVL	7	29134756	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	23804368	29134756	130003907	44	16800											
RABGEF1	27342	broad.mit.edu	37	chr7	66270262	66270262	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggatgacttcctccccacccTcatctacattgttttgaagg	7	13	2	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr7:66270262T>C	uc011kee.1	+	8	1162	c.998T>C	c.(997-999)CTC>CCC	p.L333P	RABGEF1_uc003tvf.2_Missense_Mutation_p.L192P|RABGEF1_uc003tvg.2_Missense_Mutation_p.L127P|RABGEF1_uc010lag.2_Missense_Mutation_p.L319P|RABGEF1_uc003tvh.2_Missense_Mutation_p.L319P|RABGEF1_uc003tvi.2_Missense_Mutation_p.L153P	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	536	VPS9.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						CTCCCCACCCTCATCTACATT	0.522													C	66270262	C	C	66270262	3	2	237	1	0	0	0	0	1	0	0	0	12966	1551	54	4	982	4	RABGEF1	7	66270262	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	37135506	66270262	92868401	45	16801											
C7orf64	84060	broad.mit.edu	37	chr7	92158936	92158936	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaatacccagcagaagacttTactgaagtttatcttattaa	6	7	1	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr7:92158936T>C	uc003ulz.2	+	2	299	c.258T>C	c.(256-258)TTT>TTC	p.F86F	PEX1_uc003uly.2_5'Flank|PEX1_uc011khr.1_5'Flank|PEX1_uc010ley.2_5'Flank|PEX1_uc011khs.1_5'Flank|C7orf64_uc011khu.1_Silent_p.F86F|C7orf64_uc003uma.2_Silent_p.F86F	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	86							nucleotide binding			ovary(2)	2						CAGAAGACTTTACTGAAGTTT	0.353													C	92158936	C	C	92158936	2	2	237	1	0	0	0	0	0	0	0	1	2410	1751	61	4		4	C7orf64	7	92158936	Silent	SNP	T	TCGA-32-4210-01A-01D-1353-08	25888674	92158936	66979727	46	16802											
HEPACAM2	253012	broad.mit.edu	37	chr7	92821587	92821587	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctggatggtcttgctgctgGgcagggatgtgctgaataac	15	7	2	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr7:92821587G>A	uc003umm.2	-	9	1388	c.1365C>T	c.(1363-1365)GCC>GCT	p.A455A	HEPACAM2_uc003uml.2_Silent_p.A443A|HEPACAM2_uc010lff.2_Missense_Mutation_p.P435L|HEPACAM2_uc011khy.1_Silent_p.A478A	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	455	Cytoplasmic (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						CTTGCTGCTGGGCAGGGATGT	0.453													A	92821587	A	A	92821587	2	1	237	1	0	0	0	0	0	0	0	1	7053	1219	43	3		3	HEPACAM2	7	92821587	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	662651	92821587	66317076	47	16803											
CALCR	799	broad.mit.edu	37	chr7	93055835	93055835	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcagagcggttggaggggcGcctcccccaacgctggttcc	15	14	0	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr7:93055835G>A	uc003umv.1	-	15	1621	c.1360C>T	c.(1360-1362)CGC>TGC	p.R454C	CALCR_uc011kia.1_Missense_Mutation_p.R234C|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.R420C|CALCR_uc003umw.2_Missense_Mutation_p.R420C	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	436	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TTGGAGGGGCGCCTCCCCCAA	0.557													A	93055835	A	A	93055835	3	1	237	1	0	0	0	0	1	0	0	0	2579	1087	38	1	170	1	CALCR	7	93055835	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	234248	93055835	66082828	48	16804											
ANKRD7	56311	broad.mit.edu	37	chr7	117864828	117864828	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcagaggggcagggcggaCggctaggagttcaagaaaca	19	7	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr7:117864828C>T	uc003vji.2	+	1	117	c.-56C>T	c.(-58--54)GACGG>GATGG			NM_019644	NP_062618	Q92527	ANKR7_HUMAN	ankyrin repeat domain 7						male gonad development						0						GCAGGGCGGACGGCTAGGAGT	0.602													T	117864828	T	T	117864828	1	4	237	1	0	0	0	0	0	0	0	0	686	551	19	1		1	ANKRD7	7	117864828	Translation_Start_Site	SNP	C	TCGA-32-4210-01A-01D-1353-08	24808993	117864828	41273835	49	16805											
PLAT	5327	broad.mit.edu	37	chr8	42037449	42037449	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttccttccacttacaggccTcatgcttgccgtagccggag	9	15	1	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr8:42037449T>G	uc003xos.2	-	12	1567	c.1358A>C	c.(1357-1359)GAG>GCG	p.E453A	PLAT_uc010lxf.1_Missense_Mutation_p.E370A|PLAT_uc010lxg.1_Missense_Mutation_p.E278A|PLAT_uc003xot.2_Missense_Mutation_p.E407A|PLAT_uc011lcm.1_Missense_Mutation_p.E364A|PLAT_uc011lcn.1_Missense_Mutation_p.E327A	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	453	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CTTACAGGCCTCATGCTTGCC	0.652													G	42037449	G	G	42037449	3	3	237	1	0	0	0	0	1	0	0	0	12021	1551	54	5	342	5	PLAT	8	42037449	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08		42037449	104326573	50	16806											
CYP7B1	9420	broad.mit.edu	37	chr8	65517238	65517238	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ataggcttgatgtttacttaCctctggagcttcaaagattt	8	7	2	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr8:65517238C>A	uc003xvj.2	-	5	1437	c.1233_splice	c.e5+1	p.E411_splice		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,						bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				TGTTTACTTACCTCTGGAGCT	0.493													A	65517238	A	A	65517238	5	1	237	1	0	0	0	0	0	0	1	0	4197	521	18	5	294	5	CYP7B1	8	65517238	Splice_Site	SNP	C	TCGA-32-4210-01A-01D-1353-08	23479789	65517238	80846784	51	16807											
TRAPPC9	83696	broad.mit.edu	37	chr8	141461384	141461384	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcttatagatcctgaagaagTtctcctcggagacgatgccc	9	11	2	4			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr8:141461384T>C	uc003yvj.2	-	2	223	c.89A>G	c.(88-90)AAC>AGC	p.N30S	TRAPPC9_uc003yvh.2_Missense_Mutation_p.N128S|TRAPPC9_uc003yvi.1_Missense_Mutation_p.N30S	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	30					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						CCTGAAGAAGTTCTCCTCGGA	0.567													C	141461384	C	C	141461384	3	2	237	1	0	0	0	0	1	0	0	0	16462	1725	60	4	3445	4	TRAPPC9	8	141461384	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	75944146	141461384	4902638	52	16808											
ZNF696	79943	broad.mit.edu	37	chr8	144378380	144378380	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcgggcgcacagcggggagAggccctacgcgtgcgccgag	19	13	0	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr8:144378380A>G	uc003yxy.3	+	3	944	c.535A>G	c.(535-537)AGG>GGG	p.R179G		NM_030895	NP_112157	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CAGCGGGGAGAGGCCCTACGC	0.697													G	144378380	G	G	144378380	3	3	237	1	0	0	0	0	1	0	0	0	18096	295	11	4	541	4	ZNF696	8	144378380	Missense_Mutation	SNP	A	TCGA-32-4210-01A-01D-1353-08	2916996	144378380	1985642	53	16809											
ARHGAP39	80728	broad.mit.edu	37	chr8	145806268	145806268	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actgtcccaaacgccgcgggCcgcccggccctcgctggcaa	12	19	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr8:145806268C>G	uc003zdt.1	-	4	1029	c.474G>C	c.(472-474)CGG>CGC	p.R158R	ARHGAP39_uc011llk.1_Silent_p.R158R|ARHGAP39_uc003zds.1_Silent_p.R158R	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	158					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						ACGCCGCGGGCCGCCCGGCCC	0.657													G	145806268	G	G	145806268	2	3	237	1	0	0	0	0	0	0	0	1	884	726	26	5		5	ARHGAP39	8	145806268	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08	1427888	145806268	557754	54	16810											
ARID3C	138715	broad.mit.edu	37	chr9	34623425	34623425	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccattctcccctcgcaccttTcttaatagggcttggactca	6	15	3	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr9:34623425T>C	uc011lon.1	-	4	862	c.862A>G	c.(862-864)AAA>GAA	p.K288E	DCTN3_uc003zuw.1_5'Flank|DCTN3_uc003zux.1_5'Flank	NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	288	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CTCGCACCTTTCTTAATAGGG	0.592													C	34623425	C	C	34623425	3	2	237	1	0	0	0	0	1	0	0	0	918	1792	62	4	391	4	ARID3C	9	34623425	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08		34623425	106590006	55	16811											
FAM75A6	389730	broad.mit.edu	37	chr9	43628658	43628658	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcagttgtgaaagaaggtccGaagtctcctccaggcctctc	11	12	2	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr9:43628658G>A	uc011lrb.1	-	3	313	c.284C>T	c.(283-285)TCG>TTG	p.S95L		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	95						integral to membrane					0						AAGAAGGTCCGAAGTCTCCTC	0.612													A	43628658	A	A	43628658	3	1	237	1	0	0	0	0	1	0	0	0	5622	1059	37	2	3755	2	FAM75A6	9	43628658	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	9005233	43628658	97584773	56	16812											
SLC28A3	64078	broad.mit.edu	37	chr9	86928326	86928326	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cagctctgcttcttattgagTtgtttcctgatgtgttctcg	9	9	3	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr9:86928326T>A	uc010mpz.2	-	2	229	c.104A>T	c.(103-105)AAC>ATC	p.N35I	SLC28A3_uc011lsy.1_5'UTR|SLC28A3_uc004anu.1_Missense_Mutation_p.N35I|SLC28A3_uc010mqb.2_5'UTR	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	35	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TCTTATTGAGTTGTTTCCTGA	0.418													A	86928326	A	A	86928326	3	1	237	1	0	0	0	0	1	0	0	0	14533	1725	60	5	2039	5	SLC28A3	9	86928326	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	43299668	86928326	54285105	57	16813											
ROR2	4920	broad.mit.edu	37	chr9	94487296	94487296	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctcccccggggcagggcCgaacaggtgacctttgtaga	14	13	0	2	rs138310082	byFrequency	TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr9:94487296C>T	uc004arj.1	-	9	1679	c.1480G>A	c.(1480-1482)GGC>AGC	p.G494S	ROR2_uc004ari.1_Missense_Mutation_p.G354S	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	494	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GGGGCAGGGCCGAACAGGTGA	0.602													T	94487296	T	T	94487296	3	4	237	1	0	0	0	0	1	0	0	0	13527	652	23	2	1355	2	ROR2	9	94487296	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	7558970	94487296	46726135	58	16814											
ZBTB34	403341	broad.mit.edu	37	chr9	129643102	129643102	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgagagaacagatgtgtacgTggaacagaaactagaaaatg	12	5	0	4			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr9:129643102T>G	uc004bqm.3	+	2	1509	c.1412T>G	c.(1411-1413)GTG>GGG	p.V471G		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	471					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GATGTGTACGTGGAACAGAAA	0.507													G	129643102	G	G	129643102	3	3	237	1	0	0	0	0	1	0	0	0	17534	1696	59	5	1414	5	ZBTB34	9	129643102	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	35155806	129643102	11570329	59	16815											
PRDM12	59335	broad.mit.edu	37	chr9	133556658	133556658	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acttccacccggcggactcgGcggctggccccgcgggccgc	15	19	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr9:133556658G>A	uc004bzt.1	+	5	766	c.706G>A	c.(706-708)GCG>ACG	p.A236T		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	236					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GGCGGACTCGGCGGCTGGCCC	0.622													A	133556658	A	A	133556658	3	1	237	1	0	0	0	0	1	0	0	0	12453	1203	42	3	724	3	PRDM12	9	133556658	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	3913556	133556658	7656773	60	16816											
ITGA8	8516	broad.mit.edu	37	chr10	15701007	15701007	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgtctctacctgttctccCgtgaaattctgaataaacgt	6	10	3	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr10:15701007C>T	uc001ioc.1	-	10	939	c.939G>A	c.(937-939)ACG>ACA	p.T313T	ITGA8_uc010qcb.1_Silent_p.T298T	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	313	Extracellular (Potential).|FG-GAP 5.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CCTGTTCTCCCGTGAAATTCT	0.303													T	15701007	T	T	15701007	2	4	237	1	0	0	0	0	0	0	0	1	7882	639	23	2		2	ITGA8	10	15701007	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08		15701007	119833740	61	16817											
PTCHD3	374308	broad.mit.edu	37	chr10	27702997	27702997	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggggtgcatcctgctccgaCgccaggggtcctgagggttc	16	12	0	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr10:27702997C>T	uc001itu.2	-	1	301	c.183G>A	c.(181-183)GCG>GCA	p.A61A		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	61					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CCTGCTCCGACGCCAGGGGTC	0.687													T	27702997	T	T	27702997	2	4	237	1	0	0	0	0	0	0	0	1	12734	523	19	1		1	PTCHD3	10	27702997	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08	12001990	27702997	107831750	62	16818											
PTEN	5728	broad.mit.edu	37	chr10	89717691	89717691	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acgacgggaagacaagttcaTgtactttgagttccctcagc	10	10	2	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr10:89717691T>G	uc001kfb.2	+	8	1747	c.716T>G	c.(715-717)ATG>AGG	p.M239R		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	239	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.M239fs*4(1)|p.?(1)|p.G165_K342del(1)|p.R234fs*9(1)|p.K237_Y240>N(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GACAAGTTCATGTACTTTGAG	0.413		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			G	89717691	G	G	89717691	3	3	237	1	0	0	0	0	1	0	0	0	12738	1464	51	5	742	5	PTEN	10	89717691	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	62014694	89717691	45817056	63	16819											
NFKB2	4791	broad.mit.edu	37	chr10	104156679	104156679	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatctgtaactacgagggaCcagccaagatcgaggtggac	13	9	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr10:104156679C>T	uc001kvb.2	+	6	527	c.262C>T	c.(262-264)CCA>TCA	p.P88S	NFKB2_uc001kva.2_Missense_Mutation_p.P88S|NFKB2_uc010qqk.1_Missense_Mutation_p.P88S|NFKB2_uc001kvd.2_Missense_Mutation_p.P88S|NFKB2_uc009xxc.2_Missense_Mutation_p.P88S	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	88	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		CTACGAGGGACCAGCCAAGAT	0.602			T	IGH@	B-NHL								T	104156679	T	T	104156679	3	4	237	1	0	0	0	0	1	0	0	0	10376	507	18	3	280	3	NFKB2	10	104156679	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	14438988	104156679	31378068	64	16820											
LRRC56	115399	broad.mit.edu	37	chr11	554078	554078	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gacctgcagtccagggggcgTcggctccgagtcctgggcag	17	13	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:554078T>C	uc010qvz.1	+	14	1936	c.1431T>C	c.(1429-1431)CGT>CGC	p.R477R		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	477										skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCAGGGGGCGTCGGCTCCGAG	0.697													C	554078	C	C	554078	2	2	237	1	0	0	0	0	0	0	0	1	9012	1654	58	4		4	LRRC56	11	554078	Silent	SNP	T	TCGA-32-4210-01A-01D-1353-08		554078	134452438	65	16821											
WEE1	7465	broad.mit.edu	37	chr11	9608358	9608358	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	aaagagtgcagaacaattacGaatagaattgaatgccgaaa	9	5	0	4			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:9608358G>C	uc001mhs.2	+	10	1995	c.1742G>C	c.(1741-1743)CGA>CCA	p.R581P	WEE1_uc001mht.2_Missense_Mutation_p.R367P	NM_003390	NP_003381	P30291	WEE1_HUMAN	WEE1 tyrosine kinase isoform 1	581					blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	5				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		GAACAATTACGAATAGAATTG	0.348													C	9608358	C	C	9608358	3	2	237	1	0	0	0	0	1	0	0	0	17341	1058	37	5	1780	5	WEE1	11	9608358	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	9054280	9608358	125398158	66	16822											
CHRM4	1132	broad.mit.edu	37	chr11	46407321	46407321	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgcgcagctcctcccgggCggcctccccgggcgggggct	16	17	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:46407321C>T	uc001nct.1	-	1	787	c.787G>A	c.(787-789)GCC>ACC	p.A263T		NM_000741	NP_000732	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	263	Cytoplasmic (By similarity).				cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity				0				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	TCCTCCCGGGCGGCCTCCCCG	0.682													T	46407321	T	T	46407321	3	4	237	1	0	0	0	0	1	0	0	0	3379	768	27	1	656	1	CHRM4	11	46407321	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	36798963	46407321	88599195	67	16823											
OR8H3	390152	broad.mit.edu	37	chr11	55890095	55890095	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcgtcacacctaaaaccTtagcgaacttactgacttcc	5	14	1	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:55890095T>A	uc001nii.1	+	1	247	c.247T>A	c.(247-249)TTA>ATA	p.L83I		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					ACCTAAAACCTTAGCGAACTT	0.438													A	55890095	A	A	55890095	3	1	237	1	0	0	0	0	1	0	0	0	11239	1606	56	5	249	5	OR8H3	11	55890095	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	9482774	55890095	79116421	68	16824											
OR5M11	219487	broad.mit.edu	37	chr11	56310099	56310099	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggcataggacaccaagacgAtggtgagggagctggagagg	18	6	0	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:56310099A>T	uc010rjl.1	-	1	635	c.635T>A	c.(634-636)ATC>AAC	p.I212N		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CACCAAGACGATGGTGAGGGA	0.502													T	56310099	T	T	56310099	3	4	237	1	0	0	0	0	1	0	0	0	11174	333	12	5	285	5	OR5M11	11	56310099	Missense_Mutation	SNP	A	TCGA-32-4210-01A-01D-1353-08	420004	56310099	78696417	69	16825											
AHNAK	79026	broad.mit.edu	37	chr11	62297453	62297453	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caacatcaggagcttttatcTctccttctacttttggaact	5	11	3	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:62297453T>A	uc001ntl.2	-	5	4736	c.4436A>T	c.(4435-4437)GAG>GTG	p.E1479V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1479					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGCTTTTATCTCTCCTTCTAC	0.418													A	62297453	A	A	62297453	3	1	237	1	0	0	0	0	1	0	0	0	414	1551	54	5	13356	5	AHNAK	11	62297453	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	5987354	62297453	72709063	70	16826											
PLCB3	5331	broad.mit.edu	37	chr11	64024115	64024115	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtccatggagggctttagCcgctacctgggaggcgagga	16	9	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:64024115C>T	uc001nzb.2	+	10	891	c.891C>T	c.(889-891)AGC>AGT	p.S297S	PLCB3_uc009ypg.1_Silent_p.S297S|PLCB3_uc009yph.1_Silent_p.S230S|PLCB3_uc009ypi.2_Silent_p.S297S	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	297					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						AGGGCTTTAGCCGCTACCTGG	0.632													T	64024115	T	T	64024115	2	4	237	1	0	0	0	0	0	0	0	1	12029	738	26	3		3	PLCB3	11	64024115	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08	1726662	64024115	70982401	71	16827											
ATG2A	23130	broad.mit.edu	37	chr11	64668368	64668368	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcctcacctgtggccggggTgggggccaaagtctcggccc	15	15	2	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:64668368T>G	uc001obx.2	-	30	4431	c.4316A>C	c.(4315-4317)CAC>CCC	p.H1439P	ATG2A_uc001obw.2_Missense_Mutation_p.H204P	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1439							protein binding			ovary(1)|central_nervous_system(1)	2						GTGGCCGGGGTGGGGGCCAAA	0.388													G	64668368	G	G	64668368	3	3	237	1	0	0	0	0	1	0	0	0	1093	1696	59	5	1548	5	ATG2A	11	64668368	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	644253	64668368	70338148	72	16828											
TMPRSS4	56649	broad.mit.edu	37	chr11	117975409	117975409	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttcctttcctcccagtccGcctctccaaggaccgatcca	7	18	1	0	rs140457645	byFrequency	TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:117975409G>A	uc010rxo.1	+	5	605	c.314G>A	c.(313-315)CGC>CAC	p.R105H	TMPRSS4_uc010rxp.1_Missense_Mutation_p.R105H|TMPRSS4_uc010rxq.1_5'UTR|TMPRSS4_uc010rxr.1_Missense_Mutation_p.R80H|TMPRSS4_uc010rxs.1_Missense_Mutation_p.R65H|TMPRSS4_uc009yzu.2_RNA|TMPRSS4_uc010rxt.1_Missense_Mutation_p.R80H	NM_019894	NP_063947	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4 isoform 1	105	Extracellular (Potential).|SRCR.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		CTCCCAGTCCGCCTCTCCAAG	0.587													A	117975409	A	A	117975409	3	1	237	1	0	0	0	0	1	0	0	0	16246	1087	38	1	332	1	TMPRSS4	11	117975409	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	53307041	117975409	17031107	73	16829											
C11orf63	79864	broad.mit.edu	37	chr11	122775064	122775064	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaacattttgtggaaaaaaAcaagctcactttgggattac	7	7	1	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr11:122775064A>G	uc001pym.2	+	3	1073	c.776A>G	c.(775-777)AAC>AGC	p.N259S	C11orf63_uc001pyl.1_Missense_Mutation_p.N259S	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	259										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GTGGAAAAAAACAAGCTCACT	0.463													G	122775064	G	G	122775064	3	3	237	1	0	0	0	0	1	0	0	0	1654	43	2	4	782	4	C11orf63	11	122775064	Missense_Mutation	SNP	A	TCGA-32-4210-01A-01D-1353-08	4799655	122775064	12231452	74	16830											
NR4A1	3164	broad.mit.edu	37	chr12	52451228	52451228	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcggggactggattgacaGtatcctggccttctcaaggt	12	10	1	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr12:52451228G>A	uc001rzs.2	+	7	1768	c.1454G>A	c.(1453-1455)AGT>AAT	p.S485N	NR4A1_uc010sno.1_Missense_Mutation_p.S498N|NR4A1_uc001rzt.2_Missense_Mutation_p.S485N|NR4A1_uc009zmc.2_Missense_Mutation_p.V99I	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	485					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		TGGATTGACAGTATCCTGGCC	0.612													A	52451228	A	A	52451228	3	1	237	1	0	0	0	0	1	0	0	0	10632	1029	36	3	1472	3	NR4A1	12	52451228	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08		52451228	81400667	75	16831											
AGAP2	116986	broad.mit.edu	37	chr12	58124715	58124715	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagcaagtccatctccttgcCgtgggtactgtggatgtaat	11	10	1	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr12:58124715C>A	uc001spq.2	-	11	2167	c.2167G>T	c.(2167-2169)GGC>TGC	p.G723C	AGAP2_uc001spp.2_Missense_Mutation_p.G723C|AGAP2_uc001spr.2_Missense_Mutation_p.G387C	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	723	PH.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						ATCTCCTTGCCGTGGGTACTG	0.582													A	58124715	A	A	58124715	3	1	237	1	0	0	0	0	1	0	0	0	368	652	23	5	1447	5	AGAP2	12	58124715	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	5673487	58124715	75727180	76	16832											
TDG	6996	broad.mit.edu	37	chr12	104377129	104377129	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	taaaggttaagaacttggaaTttgggcttcagccccataag	10	7	1	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr12:104377129T>A	uc001tkg.2	+	7	977	c.754T>A	c.(754-756)TTT>ATT	p.F252I	TDG_uc009zuk.2_Missense_Mutation_p.F248I|TDG_uc010swi.1_Missense_Mutation_p.F109I|TDG_uc010swj.1_Missense_Mutation_p.F40I	NM_003211	NP_003202	Q13569	TDG_HUMAN	thymine-DNA glycosylase	252					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			ovary(3)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(302;0.00114)		GAACTTGGAATTTGGGCTTCA	0.299								BER_DNA_glycosylases					A	104377129	A	A	104377129	3	1	237	1	0	0	0	0	1	0	0	0	15722	1493	52	5	780	5	TDG	12	104377129	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	46252414	104377129	29474766	77	16833											
BTBD11	121551	broad.mit.edu	37	chr12	108010913	108010913	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaggctcagtggagcatggCgaggagaactactcggaaac	15	8	1	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr12:108010913C>T	uc001tmk.1	+	8	2570	c.2049C>T	c.(2047-2049)GGC>GGT	p.G683G	BTBD11_uc009zut.1_Silent_p.G683G|BTBD11_uc001tmj.2_Silent_p.G683G|BTBD11_uc001tml.1_Silent_p.G220G	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	683						integral to membrane	DNA binding			skin(2)|ovary(1)	3						TGGAGCATGGCGAGGAGAACT	0.612													T	108010913	T	T	108010913	2	4	237	1	0	0	0	0	0	0	0	1	1539	755	27	1		1	BTBD11	12	108010913	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08	3633784	108010913	25840982	78	16834											
KSR2	283455	broad.mit.edu	37	chr12	117993076	117993076	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgtcacacggaacggactcTgtccggactaaccttgctgg	11	12	2	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr12:117993076T>C	uc001two.2	-	9	1384	c.1329A>G	c.(1327-1329)ACA>ACG	p.T443T		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	472					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAACGGACTCTGTCCGGACTA	0.478													C	117993076	C	C	117993076	2	2	237	1	0	0	0	0	0	0	0	1	8582	1567	55	4		4	KSR2	12	117993076	Silent	SNP	T	TCGA-32-4210-01A-01D-1353-08	9982163	117993076	15858819	79	16835											
DIABLO	56616	broad.mit.edu	37	chr12	122702873	122702873	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtctgagagagaaaggtagaGgtgctatctgttaccaaaga	13	5	2	4			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr12:122702873G>T	uc010tab.1	-	4	1060	c.255C>A	c.(253-255)ACC>ACA	p.T85T	DIABLO_uc010taa.1_Silent_p.T32T|DIABLO_uc010tac.1_Intron|DIABLO_uc010tad.1_Intron|VPS33A_uc001ucc.2_RNA	NM_019887	NP_063940	Q9NR28	DBLOH_HUMAN	diablo isoform 1 precursor	85				Missing (in Ref. 2; BAB71568).	activation of caspase activity by cytochrome c|induction of apoptosis via death domain receptors	CD40 receptor complex|cytosol|internal side of plasma membrane|mitochondrial intermembrane space	protein binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000302)|Epithelial(86;0.00051)|BRCA - Breast invasive adenocarcinoma(302;0.223)		GAAAGGTAGAGGTGCTATCTG	0.388													T	122702873	T	T	122702873	2	4	237	1	0	0	0	0	0	0	0	1	4517	987	35	5		5	DIABLO	12	122702873	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	4709797	122702873	11149022	80	16836											
GPR133	283383	broad.mit.edu	37	chr12	131593382	131593382	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgatcaaggtctttgggtcGgaggacagcaagcaccgtta	14	8	2	1	rs60880996	byFrequency	TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr12:131593382G>A	uc001uit.3	+	18	2560	c.2001G>A	c.(1999-2001)TCG>TCA	p.S667S	GPR133_uc010tbm.1_Silent_p.S699S|GPR133_uc009zyo.2_Intron|GPR133_uc001uiv.1_Silent_p.S186S|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	667	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TCTTTGGGTCGGAGGACAGCA	0.348													A	131593382	A	A	131593382	2	1	237	1	0	0	0	0	0	0	0	1	6643	1103	39	2		2	GPR133	12	131593382	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	8890509	131593382	2258513	81	16837											
ERCC5	2073	broad.mit.edu	37	chr13	103514821	103514821	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagagatggaaaaggaatacCgtttactgcaacacttgcgt	11	7	0	1	rs112825485		TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr13:103514821C>T	uc001vpw.2	+	8	1765	c.1322C>T	c.(1321-1323)CCG>CTG	p.P441L	ERCC5_uc001vpu.1_Missense_Mutation_p.P895L|ERCC5_uc010tjb.1_Missense_Mutation_p.P441L|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.P273L	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	441					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AAAGGAATACCGTTTACTGCA	0.493			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				T	103514821	T	T	103514821	3	4	237	1	0	0	0	0	1	0	0	0	5216	652	23	2	1352	2	ERCC5	13	103514821	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08		103514821	11655057	82	16838											
FSCB	84075	broad.mit.edu	37	chr14	44975414	44975414	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggaatttttctgttgatggAggctctatttcagcagaagc	12	6	3	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr14:44975414A>G	uc001wvn.2	-	1	1086	c.777T>C	c.(775-777)CCT>CCC	p.P259P		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	259						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CTGTTGATGGAGGCTCTATTT	0.458													G	44975414	G	G	44975414	2	3	237	1	0	0	0	0	0	0	0	1	6066	291	11	4		4	FSCB	14	44975414	Silent	SNP	A	TCGA-32-4210-01A-01D-1353-08		44975414	62374126	83	16839											
SYT16	83851	broad.mit.edu	37	chr14	62541877	62541877	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatggagccagccaacggcGttattctgagaatctctcct	11	11	2	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr14:62541877G>A	uc001xfu.1	+	3	958	c.761G>A	c.(760-762)CGT>CAT	p.R254H	SYT16_uc010tsd.1_Missense_Mutation_p.R254H	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	254										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		AGCCAACGGCGTTATTCTGAG	0.428													A	62541877	A	A	62541877	3	1	237	1	0	0	0	0	1	0	0	0	15469	1145	40	1	771	1	SYT16	14	62541877	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	17566463	62541877	44807663	84	16840											
MAP3K9	4293	broad.mit.edu	37	chr14	71216774	71216774	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagggcacctcaccagtcagCaactcccaaagtagcacccc	7	17	2	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr14:71216774C>A	uc001xmm.2	-	4	1026	c.1026G>T	c.(1024-1026)TTG>TTT	p.L342F	MAP3K9_uc010ttk.1_Missense_Mutation_p.L79F|MAP3K9_uc001xmk.2_Missense_Mutation_p.L36F|MAP3K9_uc001xml.2_Missense_Mutation_p.L342F	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	342	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CACCAGTCAGCAACTCCCAAA	0.488													A	71216774	A	A	71216774	3	1	237	1	0	0	0	0	1	0	0	0	9257	709	25	5	2370	5	MAP3K9	14	71216774	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	8674897	71216774	36132766	85	16841											
CACNA1H	8912	broad.mit.edu	37	chr16	1270781	1270781	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggagaccctttcttggaCggtagccacagtgtgacccc	12	12	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:1270781C>T	uc002cks.2	+	35	7097	c.6849C>T	c.(6847-6849)GAC>GAT	p.D2283D	CACNA1H_uc002ckt.2_Silent_p.D2277D|CACNA1H_uc002cku.2_Silent_p.D978D|CACNA1H_uc010brj.2_Silent_p.D994D|CACNA1H_uc002ckv.2_Silent_p.D972D	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	2283	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CTTTCTTGGACGGTAGCCACA	0.652													T	1270781	T	T	1270781	2	4	237	1	0	0	0	0	0	0	0	1	2545	535	19	1		1	CACNA1H	16	1270781	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08		1270781	89083972	86	16842											
ZNF263	10127	broad.mit.edu	37	chr16	3339529	3339529	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaagacctcatgaccggtcGcaaggggattgggcgcctcc	15	12	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:3339529G>A	uc002cuq.2	+	6	1355	c.1023G>A	c.(1021-1023)TCG>TCA	p.S341S	ZNF263_uc010uww.1_5'UTR|ZNF263_uc002cur.2_5'UTR	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	341					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						ATGACCGGTCGCAAGGGGATT	0.632													A	3339529	A	A	3339529	2	1	237	1	0	0	0	0	0	0	0	1	17800	1074	38	1		1	ZNF263	16	3339529	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	2068748	3339529	87015224	87	16843											
IQCK	124152	broad.mit.edu	37	chr16	19729740	19729740	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ccgtgtctctcgcgtcccgcGagctgcctgtctcgtcgtgg	13	16	2	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:19729740G>C	uc002dgr.2	+	2	811	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	IQCK_uc002dgs.2_RNA|IQCK_uc010vat.1_Missense_Mutation_p.E38Q|IQCK_uc010bwc.2_RNA|IQCK_uc010vau.1_5'UTR|C16orf88_uc002dgq.2_5'Flank	NM_153208	NP_694940	Q8N0W5	IQCK_HUMAN	IQ motif containing K	38										skin(1)	1						CGCGTCCCGCGAGCTGCCTGT	0.652													C	19729740	C	C	19729740	3	2	237	1	0	0	0	0	1	0	0	0	7813	1059	37	5	114	5	IQCK	16	19729740	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	16390211	19729740	70625013	88	16844											
MVP	9961	broad.mit.edu	37	chr16	29855978	29855978	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaactcagcccgcatcattcGcactgctgtctttggctttg	9	13	3	0	rs148167046		TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:29855978G>A	uc002dui.2	+	11	1883	c.1799G>A	c.(1798-1800)CGC>CAC	p.R600H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc002duj.2_Missense_Mutation_p.R600H|MVP_uc010vea.1_Missense_Mutation_p.R194H	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	600					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CGCATCATTCGCACTGCTGTC	0.617													A	29855978	A	A	29855978	3	1	237	1	0	0	0	0	1	0	0	0	9996	1087	38	1	1837	1	MVP	16	29855978	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	10126238	29855978	60498775	89	16845											
PRSS36	146547	broad.mit.edu	37	chr16	31151818	31151818	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acccaggggtctcacctcggTcctggggttctttccagccc	11	16	2	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:31151818T>C	uc002ebd.2	-	13	2221	c.2162A>G	c.(2161-2163)GAC>GGC	p.D721G	PRSS36_uc010vff.1_Missense_Mutation_p.D496G|PRSS36_uc010vfg.1_Missense_Mutation_p.D716G|PRSS36_uc010vfh.1_Intron	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	721	Peptidase S1 3.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						CTCACCTCGGTCCTGGGGTTC	0.667													C	31151818	C	C	31151818	3	2	237	1	0	0	0	0	1	0	0	0	12625	1667	58	4	417	4	PRSS36	16	31151818	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	1295840	31151818	59202935	90	16846											
RPGRIP1L	23322	broad.mit.edu	37	chr16	53686572	53686572	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggacctcaagggtgatagtaTtcttctgaatatattgcaaa	9	6	3	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:53686572T>C	uc002ehp.2	-	15	2091	c.2027A>G	c.(2026-2028)AAT>AGT	p.N676S	RPGRIP1L_uc002eho.3_Missense_Mutation_p.N676S|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.N676S|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.N676S|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.N676S	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	676	C2 1.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				GGTGATAGTATTCTTCTGAAT	0.378													C	53686572	C	C	53686572	3	2	237	1	0	0	0	0	1	0	0	0	13550	1493	52	4	1972	4	RPGRIP1L	16	53686572	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	22534754	53686572	36668181	91	16847											
NUDT21	11051	broad.mit.edu	37	chr16	56473612	56473612	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccaccagttaccaatgcaaTcgtcaatgacccagtcttgc	6	14	2	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:56473612T>C	uc002eja.2	-	4	575	c.428A>G	c.(427-429)GAT>GGT	p.D143G	NUDT21_uc002eiz.2_Missense_Mutation_p.D68G	NM_007006	NP_008937	O43809	CPSF5_HUMAN	cleavage and polyadenylation specific factor 5	143	Nudix hydrolase.|Necessary for interactions with PAPOLA and PABPN1.|Necessary for RNA-binding.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	centrosome|mRNA cleavage factor complex|paraspeckles	AU-rich element binding|histone deacetylase binding|hydrolase activity|mRNA binding|protein homodimerization activity				0						ACCAATGCAATCGTCAATGAC	0.408													C	56473612	C	C	56473612	3	2	237	1	0	0	0	0	1	0	0	0	10738	1435	50	4	271	4	NUDT21	16	56473612	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	2787040	56473612	33881141	92	16848											
TMEM208	29100	broad.mit.edu	37	chr16	67261781	67261781	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gagggaagaagcagatatttGaagagaacagagagactctg	14	4	1	6			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:67261781G>C	uc002esi.2	+	2	155	c.49G>C	c.(49-51)GAA>CAA	p.E17Q	LRRC29_uc002ese.2_5'Flank|LRRC29_uc002esf.2_5'Flank|LRRC29_uc002esg.2_5'Flank|LRRC29_uc010vjg.1_5'Flank|TMEM208_uc002esj.2_RNA	NM_014187	NP_054906	Q9BTX3	TM208_HUMAN	HSPC171 protein	17						integral to membrane					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GCAGATATTTGAAGAGAACAG	0.532													C	67261781	C	C	67261781	3	2	237	1	0	0	0	0	1	0	0	0	16130	1291	45	5	55	5	TMEM208	16	67261781	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	10788169	67261781	23092972	93	16849											
EDC4	23644	broad.mit.edu	37	chr16	67914753	67914753	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccccagctcgggcttgatggAggccctggggatggagatcg	17	11	0	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:67914753A>G	uc002eur.2	+	18	2557	c.2391A>G	c.(2389-2391)GGA>GGG	p.G797G	EDC4_uc010cer.2_Silent_p.G416G|EDC4_uc002eus.2_Silent_p.G527G|EDC4_uc002eut.1_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	797					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		GGCTTGATGGAGGCCCTGGGG	0.672													G	67914753	G	G	67914753	2	3	237	1	0	0	0	0	0	0	0	1	4908	291	11	4		4	EDC4	16	67914753	Silent	SNP	A	TCGA-32-4210-01A-01D-1353-08	652972	67914753	22440000	94	16850											
PLCG2	5336	broad.mit.edu	37	chr16	81942161	81942161	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttcctggttcgggagagCgagaccttccccaatgacta	10	13	0	3	rs11548654		TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr16:81942161C>T	uc002fgt.2	+	17	1850	c.1698C>T	c.(1696-1698)AGC>AGT	p.S566S	PLCG2_uc010chg.1_Silent_p.S566S	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	566	SH2 1.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TTCGGGAGAGCGAGACCTTCC	0.592													T	81942161	T	T	81942161	2	4	237	1	0	0	0	0	0	0	0	1	12036	767	27	1		1	PLCG2	16	81942161	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08	14027408	81942161	8412592	95	16851											
DERL2	51009	broad.mit.edu	37	chr17	5383436	5383436	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ttgggaaatacatcttccaaGaaaaaatatatgtgtccaac	6	7	1	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr17:5383436G>T	uc002gcc.1	-	6	568	c.552C>A	c.(550-552)TTC>TTA	p.F184L		NM_016041	NP_057125	Q9GZP9	DERL2_HUMAN	Der1-like domain family, member 2	184	Helical; Name=4; (Potential).				endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of cell growth|positive regulation of cell proliferation|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	protein binding				0						CATCTTCCAAGAAAAAATATA	0.358													T	5383436	T	T	5383436	3	4	237	1	0	0	0	0	1	0	0	0	4447	933	33	5	175	5	DERL2	17	5383436	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08		5383436	75811774	96	16852											
TP53	7157	broad.mit.edu	37	chr17	7577544	7577544	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaggatgggcctccggttcAtgccgcccatgcaggaactg	14	12	1	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr17:7577544A>C	uc002gim.2	-	7	931	c.737T>G	c.(736-738)ATG>AGG	p.M246R	TP53_uc002gig.1_Missense_Mutation_p.M246R|TP53_uc002gih.2_Missense_Mutation_p.M246R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.M114R|TP53_uc010cng.1_Missense_Mutation_p.M114R|TP53_uc002gii.1_Missense_Mutation_p.M114R|TP53_uc010cnh.1_Missense_Mutation_p.M246R|TP53_uc010cni.1_Missense_Mutation_p.M246R|TP53_uc002gij.2_Missense_Mutation_p.M246R|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.M153R|TP53_uc002gio.2_Missense_Mutation_p.M114R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	246	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		M -> R (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> L (in sporadic cancers; somatic mutation).|M -> I (in sporadic cancers; somatic mutation).|M -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M246V(28)|p.M246I(24)|p.M246R(10)|p.M246K(8)|p.0?(7)|p.M246T(6)|p.M246L(2)|p.M246fs*1(2)|p.M246_P250delMNRRP(2)|p.G244fs*17(1)|p.C242fs*98(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245fs*14(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTCCGGTTCATGCCGCCCAT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7577544	C	C	7577544	3	2	237	1	0	0	0	0	1	0	0	0	16378	217	8	5	553	5	TP53	17	7577544	Missense_Mutation	SNP	A	TCGA-32-4210-01A-01D-1353-08	2194108	7577544	73617666	97	16853											
DNAH2	146754	broad.mit.edu	37	chr17	7640511	7640511	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctaagctgatcagtctcatcCgcatcatctgggtcaactct	7	13	6	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr17:7640511C>T	uc002giu.1	+	7	1119	c.1105C>T	c.(1105-1107)CGC>TGC	p.R369C	DNAH2_uc002git.2_Missense_Mutation_p.R369C|DNAH2_uc010vuk.1_Missense_Mutation_p.R369C	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	369	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAGTCTCATCCGCATCATCTG	0.517													T	7640511	T	T	7640511	3	4	237	1	0	0	0	0	1	0	0	0	4602	652	23	2	1131	2	DNAH2	17	7640511	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	62967	7640511	73554699	98	16854											
ALOX15B	247	broad.mit.edu	37	chr17	7943287	7943287	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggaggagcttcaggcccgGcaggagatgtaccagtgagg	17	9	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr17:7943287G>A	uc002gju.2	+	3	551	c.435G>A	c.(433-435)CGG>CGA	p.R145R	ALOX15B_uc002gjv.2_Silent_p.R145R|ALOX15B_uc002gjw.2_Silent_p.R145R|ALOX15B_uc010vun.1_Silent_p.R145R|ALOX15B_uc010cnp.2_5'UTR	NM_001141	NP_001132	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, second type	145	Lipoxygenase.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1						TTCAGGCCCGGCAGGAGATGT	0.607													A	7943287	A	A	7943287	2	1	237	1	0	0	0	0	0	0	0	1	539	1190	42	3		3	ALOX15B	17	7943287	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	302776	7943287	73251923	99	16855											
GLP2R	9340	broad.mit.edu	37	chr17	9737155	9737155	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctccttgaggaaacgactcGgaagtgggctcagtacaaac	11	11	1	1	rs147858947	byFrequency	TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr17:9737155G>A	uc002gmd.1	+	2	221	c.221G>A	c.(220-222)CGG>CAG	p.R74Q	GLP2R_uc010cog.1_RNA	NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	74	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	GAAACGACTCGGAAGTGGGCT	0.413													A	9737155	A	A	9737155	3	1	237	1	0	0	0	0	1	0	0	0	6453	1116	39	2	227	2	GLP2R	17	9737155	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	1793868	9737155	71458055	100	16856											
MYH13	8735	broad.mit.edu	37	chr17	10243484	10243484	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caccaggagtcttggtctcaTtgggaatcagacatcgtaca	10	10	3	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr17:10243484T>C	uc002gmk.1	-	18	2129	c.2039A>G	c.(2038-2040)AAT>AGT	p.N680S		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	680	Myosin head-like.|Actin-binding (By similarity).				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CTTGGTCTCATTGGGAATCAG	0.423													C	10243484	C	C	10243484	3	2	237	1	0	0	0	0	1	0	0	0	10032	1493	52	4	3873	4	MYH13	17	10243484	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	506329	10243484	70951726	101	16857											
CETN1	1068	broad.mit.edu	37	chr18	580606	580606	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggcttcgaacccaggaaGgaagagatgaagaaaatgat	13	6	0	4			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr18:580606G>A	uc002kko.1	+	1	240	c.198G>A	c.(196-198)AAG>AAA	p.K66K		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	66	EF-hand 2.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						AACCCAGGAAGGAAGAGATGA	0.557													A	580606	A	A	580606	2	1	237	1	0	0	0	0	0	0	0	1	3274	991	35	3		3	CETN1	18	580606	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08		580606	77496642	102	16858											
MYOM1	8736	broad.mit.edu	37	chr18	3126851	3126851	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tccaagaaccattgagtcacGaaaactttcaagacaggtga	8	9	2	4			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr18:3126851G>A	uc002klp.2	-	19	3173	c.2839C>T	c.(2839-2841)CGT>TGT	p.R947C	MYOM1_uc002klq.2_Missense_Mutation_p.R851C	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	947	Fibronectin type-III 4.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						ATTGAGTCACGAAAACTTTCA	0.423													A	3126851	A	A	3126851	3	1	237	1	0	0	0	0	1	0	0	0	10091	1058	37	2	2298	2	MYOM1	18	3126851	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	2546245	3126851	74950397	103	16859											
DSC2	1824	broad.mit.edu	37	chr18	28659892	28659892	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctatccaggcttctgaaaacTttgattgatcctgtattttc	6	9	1	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr18:28659892T>A	uc002kwl.3	-	11	2038	c.1584A>T	c.(1582-1584)AAA>AAT	p.K528N	DSC2_uc002kwk.3_Missense_Mutation_p.K528N	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	528	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTCTGAAAACTTTGATTGATC	0.343													A	28659892	A	A	28659892	3	1	237	1	0	0	0	0	1	0	0	0	4766	1606	56	5	1185	5	DSC2	18	28659892	Missense_Mutation	SNP	T	TCGA-32-4210-01A-01D-1353-08	25533041	28659892	49417356	104	16860											
TNFSF9	8744	broad.mit.edu	37	chr19	6531065	6531065	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcatggaatacgcctctgaCgcttcactggaccccgaagc	10	14	3	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr19:6531065C>T	uc002mfh.2	+	1	56	c.18C>T	c.(16-18)GAC>GAT	p.D6D		NM_003811	NP_003802	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily,	6	Cytoplasmic (Potential).				apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						ACGCCTCTGACGCTTCACTGG	0.632													T	6531065	T	T	6531065	2	4	237	1	0	0	0	0	0	0	0	1	16309	535	19	1		1	TNFSF9	19	6531065	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08		6531065	52597918	105	16861											
FBN3	84467	broad.mit.edu	37	chr19	8200953	8200953	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtgacaaaggccaccactgaCaatgcactcgtccacatctg	8	14	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr19:8200953C>G	uc002mjf.2	-	12	1504	c.1483G>C	c.(1483-1485)GTC>CTC	p.V495L		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	495	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCACCACTGACAATGCACTCG	0.612													G	8200953	G	G	8200953	3	3	237	1	0	0	0	0	1	0	0	0	5704	478	17	5	7154	5	FBN3	19	8200953	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	1669888	8200953	50928030	106	16862											
WDR83	84292	broad.mit.edu	37	chr19	12779320	12779320	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaagagtcacttgttctgtAgggcaagtctcacatgaagc	10	9	4	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr19:12779320A>G	uc002mue.3	+	2	180	c.-155_splice	c.e2-2		MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002muc.2_Splice_Site|C19orf56_uc002mud.2_Intron|WDR83_uc010dyw.2_5'Flank	NM_001099737	NP_001093207	Q9BRX9	WDR83_HUMAN	mitogen-activated protein kinase organizer 1						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				lung(1)|breast(1)	2						CTTGTTCTGTAGGGCAAGTCT	0.557													G	12779320	G	G	12779320	5	3	237	1	0	0	0	0	0	0	1	0	17329	434	15	4		4	WDR83	19	12779320	Splice_Site	SNP	A	TCGA-32-4210-01A-01D-1353-08	4578367	12779320	46349663	107	16863											
MYO9B	4650	broad.mit.edu	37	chr19	17308666	17308666	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cccgtccctggccaaggctcAggtaacaacaacacggcaaa	9	15	1	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr19:17308666A>G	uc010eak.2	+	23	4264	c.4112A>G	c.(4111-4113)CAG>CGG	p.Q1371R	MYO9B_uc002nfi.2_Missense_Mutation_p.Q1371R|MYO9B_uc002nfj.1_Missense_Mutation_p.Q1371R|MYO9B_uc002nfl.1_5'Flank	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1371	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GCCAAGGCTCAGGTAACAAca	0.308													G	17308666	G	G	17308666	3	3	237	1	0	0	0	0	1	0	0	0	10085	202	7	4	4198	4	MYO9B	19	17308666	Missense_Mutation	SNP	A	TCGA-32-4210-01A-01D-1353-08	4529346	17308666	41820317	108	16864											
ZFP30	22835	broad.mit.edu	37	chr19	38127033	38127033	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgagttttctgtaagtagGcattttttcagaggtggttt	12	3	2	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr19:38127033G>A	uc002ogv.1	-	6	925	c.409C>T	c.(409-411)CCT>TCT	p.P137S	ZFP30_uc002ogw.1_Missense_Mutation_p.P137S|ZFP30_uc002ogx.1_Missense_Mutation_p.P137S|ZFP30_uc010xtt.1_Missense_Mutation_p.P136S	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTGTAAGTAGGCATTTTTTCA	0.408													A	38127033	A	A	38127033	3	1	237	1	0	0	0	0	1	0	0	0	17641	1203	42	3	1154	3	ZFP30	19	38127033	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	20818367	38127033	21001950	109	16865											
CEACAM4	1089	broad.mit.edu	37	chr19	42133314	42133314	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgccctccacggggagcGgctgagggggggcccatggt	19	12	0	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr19:42133314G>A	uc002orh.1	-	1	129	c.18C>T	c.(16-18)GCC>GCT	p.A6A	CEACAM4_uc010xwd.1_Silent_p.A6A	NM_001817	NP_001808	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion	6						integral to plasma membrane|membrane fraction					0						CACGGGGAGCGGCTGAGGGGG	0.652													A	42133314	A	A	42133314	2	1	237	1	0	0	0	0	0	0	0	1	3194	1103	39	2		2	CEACAM4	19	42133314	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	4006281	42133314	16995669	110	16866											
CLPTM1	1209	broad.mit.edu	37	chr19	45476426	45476426	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggccccggaggagctccaCgcgtcgccagccgcaacctg	14	18	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr19:45476426C>T	uc002pai.2	+	3	283	c.268C>T	c.(268-270)CGC>TGC	p.R90C	CLPTM1_uc010ejv.1_Translation_Start_Site|CLPTM1_uc010xxf.1_Translation_Start_Site|CLPTM1_uc010xxg.1_Missense_Mutation_p.R76C	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	90	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		AGGAGCTCCACGCGTCGCCAG	0.627													T	45476426	T	T	45476426	3	4	237	1	0	0	0	0	1	0	0	0	3554	536	19	1	278	1	CLPTM1	19	45476426	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	3343112	45476426	13652557	111	16867											
LILRA5	353514	broad.mit.edu	37	chr19	54823150	54823150	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacctgtcaccaccagctcCagggggtcgctgggctctga	12	15	3	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr19:54823150C>T	uc002qfe.2	-	4	513	c.393G>A	c.(391-393)CTG>CTA	p.L131L	LILRA5_uc002qff.2_Silent_p.L119L|LILRA5_uc010yev.1_Silent_p.L131L|LILRA5_uc010yew.1_Silent_p.L119L|LILRA5_uc002qfh.1_Silent_p.L119L|LILRA5_uc002qfg.1_Silent_p.L131L	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	131	Extracellular (Potential).|Ig-like C2-type 1.				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCACCAGCTCCAGGGGGTCGC	0.622													T	54823150	T	T	54823150	2	4	237	1	0	0	0	0	0	0	0	1	8788	581	21	3		3	LILRA5	19	54823150	Silent	SNP	C	TCGA-32-4210-01A-01D-1353-08	9346724	54823150	4305833	112	16868											
NLRP13	126204	broad.mit.edu	37	chr19	56422072	56422072	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcaaatgctgttccatgcGtgcatcctggaatcaaactt	9	10	1	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr19:56422072G>A	uc010ygg.1	-	6	2164	c.2139C>T	c.(2137-2139)CAC>CAT	p.H713H		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	713							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TGTTCCATGCGTGCATCCTGG	0.463													A	56422072	A	A	56422072	2	1	237	1	0	0	0	0	0	0	0	1	10475	1136	40	1		1	NLRP13	19	56422072	Silent	SNP	G	TCGA-32-4210-01A-01D-1353-08	1598922	56422072	2706911	113	16869											
CPXM1	56265	broad.mit.edu	37	chr20	2776322	2776322	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggctgtggcagggtcggCggctggtgtcctgcatggcc	18	12	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr20:2776322C>T	uc002wgu.2	-	11	1707	c.1643G>A	c.(1642-1644)CGC>CAC	p.R548H	CPXM1_uc010gas.2_Intron	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	548					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						GCAGGGTCGGCGGCTGGTGTC	0.622													T	2776322	T	T	2776322	3	4	237	1	0	0	0	0	1	0	0	0	3837	768	27	1	577	1	CPXM1	20	2776322	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08		2776322	60249198	114	16870											
ProSAPiP1	9762	broad.mit.edu	37	chr20	3146165	3146165	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccacttagtttcctctatcCggggcaggaagtcggcctgc	11	14	1	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr20:3146165C>T	uc002wia.1	-	2	2699	c.1301G>A	c.(1300-1302)CGG>CAG	p.R434Q	ProSAPiP1_uc002wib.1_Missense_Mutation_p.R388Q	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	434	Potential.					cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						TTCCTCTATCCGGGGCAGGAA	0.662													T	3146165	T	T	3146165	3	4	237	1	0	0	0	0	1	0	0	0	12870	652	23	2	728	2	ProSAPiP1	20	3146165	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08	369843	3146165	59879355	115	16871											
CRLS1	54675	broad.mit.edu	37	chr20	5996124	5996124	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atgttagcttgacctatgcaGatcttattccaggtaagaac	8	8	1	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr20:5996124G>T	uc002wmn.3	+	3	716	c.562G>T	c.(562-564)GAT>TAT	p.D188Y	CRLS1_uc010gbq.2_RNA|CRLS1_uc010gbr.2_Missense_Mutation_p.D89Y|CRLS1_uc010gbs.1_Missense_Mutation_p.D77Y	NM_019095	NP_061968	Q9UJA2	CRLS1_HUMAN	cardiolipin synthase 1 isoform 1	188					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphotransferase activity, for other substituted phosphate groups				0						GACCTATGCAGATCTTATTCC	0.383													T	5996124	T	T	5996124	3	4	237	1	0	0	0	0	1	0	0	0	3889	942	33	5	585	5	CRLS1	20	5996124	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	2849959	5996124	57029396	116	16872											
SALL4	57167	broad.mit.edu	37	chr20	50401201	50401201	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgggctgagttattgttcGccccgtgtgtcatgtagtga	15	8	1	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr20:50401201G>A	uc002xwh.3	-	4	2866	c.2765C>T	c.(2764-2766)GCG>GTG	p.A922V	SALL4_uc010gii.2_Missense_Mutation_p.A485V|SALL4_uc002xwi.3_Missense_Mutation_p.A145V	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	922					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GTTATTGTTCGCCCCGTGTGT	0.468													A	50401201	A	A	50401201	3	1	237	1	0	0	0	0	1	0	0	0	13813	1087	38	1	400	1	SALL4	20	50401201	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	44405077	50401201	12624319	117	16873											
LZTR1	8216	broad.mit.edu	37	chr22	21345975	21345975	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccccaccacccccgcagcggCgctacgggcataccatggtg	11	19	0	0			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chr22:21345975C>A	uc002zto.2	+	9	953	c.850C>A	c.(850-852)CGC>AGC	p.R284S	LZTR1_uc002ztn.2_Missense_Mutation_p.R243S|LZTR1_uc011ahy.1_Missense_Mutation_p.R265S|LZTR1_uc010gsr.1_Missense_Mutation_p.R155S	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	284	Kelch 4.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CCCGCAGCGGCGCTACGGGCA	0.632													A	21345975	A	A	21345975	3	1	237	1	0	0	0	0	1	0	0	0	9137	768	27	5	884	5	LZTR1	22	21345975	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08		21345975	29958591	118	16874											
ESX1	80712	broad.mit.edu	37	chrX	103495282	103495282	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggcccgggtggcacaggcGccatgcgtgagccgggtggc	20	12	0	1			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chrX:103495282G>A	uc004ely.2	-	4	906	c.848C>T	c.(847-849)GCG>GTG	p.A283V		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	283	5.|15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGCACAGGCGCCATGCGTGA	0.498													A	103495282	A	A	103495282	3	1	237	1	0	0	0	0	1	0	0	0	5263	1087	38	1	376	1	ESX1	23	103495282	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08		103495282	51775278	119	16875											
GPC3	2719	broad.mit.edu	37	chrX	133087081	133087081	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	aatccccagaactcaccttgGaaaaccgcagcattctgaat	6	13	2	2			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chrX:133087081G>C	uc004exe.1	-	2	523	c.333C>G	c.(331-333)TTC>TTG	p.F111L	GPC3_uc010nrn.1_Missense_Mutation_p.F111L|GPC3_uc011mvh.1_Intron|GPC3_uc010nro.1_Intron|GPC3_uc010nrp.1_5'UTR	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	111						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					ACTCACCTTGGAAAACCGCAG	0.373			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				C	133087081	C	C	133087081	3	2	237	1	0	0	0	0	1	0	0	0	6599	1165	41	5	1510	5	GPC3	23	133087081	Missense_Mutation	SNP	G	TCGA-32-4210-01A-01D-1353-08	29591799	133087081	22183479	120	16876											
NLGN4Y	22829	broad.mit.edu	37	chrY	16952864	16952864	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caaatgatatcactcacatcCagaacgaagagatcatgtct	6	10	4	3			TCGA-32-4210-01A-01D-1353-08	TCGA-32-4210-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	9f405dbf-5cc8-4414-bcbd-84ae10749ff2	fd897db5-4c2a-4614-8dca-ae20cb627fd2	g.chrY:16952864C>G	uc004ftg.2	+	6	2425	c.2173C>G	c.(2173-2175)CAG>GAG	p.Q725E	NLGN4Y_uc004fte.2_Missense_Mutation_p.Q557E|NLGN4Y_uc011nas.1_Missense_Mutation_p.Q745E|NLGN4Y_uc004ftf.2_Missense_Mutation_p.Q418E|NLGN4Y_uc004fth.2_Missense_Mutation_p.Q725E	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	725	Cytoplasmic (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						CACTCACATCCAGAACGAAGA	0.547													G	16952864	G	G	16952864	3	3	237	1	0	0	0	0	1	0	0	0	10465	595	21	5	2345	5	NLGN4Y	24	16952864	Missense_Mutation	SNP	C	TCGA-32-4210-01A-01D-1353-08		16952864	42420702	121	16877											
AADACL4	343066	broad.mit.edu	37	chr1	12726355	12726355	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtgtacccccagacgtctGgaggaagtacgagaagtggc	14	9	1	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr1:12726355G>A	uc001auf.2	+	4	833	c.833G>A	c.(832-834)TGG>TAG	p.W278*		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	278	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		CCAGACGTCTGGAGGAAGTAC	0.532													A	12726355	A	A	12726355	4	1	238	1	0	0	0	0	0	1	0	0	13	1357	47	3	847	3	AADACL4	1	12726355	Nonsense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08		12726355	236524266	1	16878											
LAPTM5	7805	broad.mit.edu	37	chr1	31210478	31210478	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ataaggacagtgatgaaggcGatggaaaagatgatcatcat	12	4	2	4	rs144620246	byFrequency	TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr1:31210478G>A	uc001bsc.2	-	6	670	c.579C>T	c.(577-579)ATC>ATT	p.I193I		NM_006762	NP_006753	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	193	Helical; (Potential).				transport	integral to plasma membrane|lysosomal membrane					0		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		TGATGAAGGCGATGGAAAAGA	0.542													A	31210478	A	A	31210478	2	1	238	1	0	0	0	0	0	0	0	1	8626	1048	37	2		2	LAPTM5	1	31210478	Silent	SNP	G	TCGA-32-4211-01A-01D-1353-08	18484123	31210478	218040143	2	16879											
GJA9	81025	broad.mit.edu	37	chr1	39340374	39340374	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatcagcagtgtttggaatgTcaagtgattgagaatctcct	10	6	3	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr1:39340374T>C	uc001cct.1	-	2	1678	c.1397A>G	c.(1396-1398)GAC>GGC	p.D466G	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	466	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			GTTTGGAATGTCAAGTGATTG	0.493													C	39340374	C	C	39340374	3	2	238	1	0	0	0	0	1	0	0	0	6406	1667	58	4	154	4	GJA9	1	39340374	Missense_Mutation	SNP	T	TCGA-32-4211-01A-01D-1353-08	8129896	39340374	209910247	3	16880											
DMBX1	127343	broad.mit.edu	37	chr1	46976216	46976216	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagccgcacagcgttcacgGctcagcagctcgaggccctg	13	16	2	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr1:46976216G>A	uc001cpx.2	+	2	253	c.238G>A	c.(238-240)GCT>ACT	p.A80T	DMBX1_uc001cpw.2_Missense_Mutation_p.A75T	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	80	Homeobox.|Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AGCGTTCACGGCTCAGCAGCT	0.582													A	46976216	A	A	46976216	3	1	238	1	0	0	0	0	1	0	0	0	4578	1203	42	3	244	3	DMBX1	1	46976216	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	7635842	46976216	202274405	4	16881											
SPTA1	6708	broad.mit.edu	37	chr1	158647548	158647548	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaacagtccttcagaggcaaCaaggtctttgccatagtcct	8	11	2	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr1:158647548C>G	uc001fst.1	-	7	1088	c.889G>C	c.(889-891)GTT>CTT	p.V297L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	297	Spectrin 4.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCAGAGGCAACAAGGTCTTTG	0.478													G	158647548	G	G	158647548	3	3	238	1	0	0	0	0	1	0	0	0	15115	478	17	5	6554	5	SPTA1	1	158647548	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	111671332	158647548	90603073	5	16882											
USH2A	7399	broad.mit.edu	37	chr1	215848824	215848824	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtccacagaggctgaggcgcCgagtgtgcacaacctgctct	13	13	1	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr1:215848824C>T	uc001hku.1	-	63	12816	c.12429G>A	c.(12427-12429)TCG>TCA	p.S4143S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4143	Fibronectin type-III 26.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCTGAGGCGCCGAGTGTGCAC	0.572										HNSCC(13;0.011)			T	215848824	T	T	215848824	2	4	238	1	0	0	0	0	0	0	0	1	17033	639	23	2		2	USH2A	1	215848824	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	57201276	215848824	33401797	6	16883											
WDR26	80232	broad.mit.edu	37	chr1	224586247	224586247	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatttaacaaagctaatcgGccattttttgaaatagtaaa	5	6	0	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr1:224586247G>A	uc001hop.3	-	11	1539	c.1173C>T	c.(1171-1173)GGC>GGT	p.G391G	WDR26_uc001hoq.3_Silent_p.G375G|WDR26_uc010pvh.1_Silent_p.G98G	NM_025160	NP_079436	Q9H7D7	WDR26_HUMAN	WD repeat domain 26 isoform a	538	WD 4.					cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)		AAGCTAATCGGCCATTTTTTG	0.274													A	224586247	A	A	224586247	2	1	238	1	0	0	0	0	0	0	0	1	17280	1190	42	3		3	WDR26	1	224586247	Silent	SNP	G	TCGA-32-4211-01A-01D-1353-08	8737423	224586247	24664374	7	16884											
RYR2	6262	broad.mit.edu	37	chr1	237777926	237777926	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taccctgctgatcatgggcaTctttcacaacgaggacttga	9	11	3	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr1:237777926T>C	uc001hyl.1	+	37	5618	c.5498T>C	c.(5497-5499)ATC>ACC	p.I1833T		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1833	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCATGGGCATCTTTCACAAC	0.498													C	237777926	C	C	237777926	3	2	238	1	0	0	0	0	1	0	0	0	13769	1435	50	4	5644	4	RYR2	1	237777926	Missense_Mutation	SNP	T	TCGA-32-4211-01A-01D-1353-08	13191679	237777926	11472695	8	16885											
TPO	7173	broad.mit.edu	37	chr2	1459947	1459947	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggcatggggacaatacatcGaccacgacatcgcgttcaca	10	12	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:1459947G>A	uc002qww.2	+	7	803	c.712G>A	c.(712-714)GAC>AAC	p.D238N	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.D238N|TPO_uc002qwr.2_Missense_Mutation_p.D238N|TPO_uc002qwx.2_Missense_Mutation_p.D238N|TPO_uc010yio.1_Missense_Mutation_p.D238N|TPO_uc010yip.1_Missense_Mutation_p.D238N	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	238	Extracellular (Potential).	Heme (covalent; via 2 links) (By similarity).			cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ACAATACATCGACCACGACAT	0.522													A	1459947	A	A	1459947	3	1	238	1	0	0	0	0	1	0	0	0	16407	1058	37	2	734	2	TPO	2	1459947	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08		1459947	241739426	9	16886											
NT5C1B	93034	broad.mit.edu	37	chr2	18765887	18765887	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccgctgctgctgctgctgctCggacagagagttgcggtcca	14	13	0	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:18765887C>T	uc002rcz.2	-	5	900	c.796G>A	c.(796-798)GAG>AAG	p.E266K	NT5C1B_uc002rcy.2_Missense_Mutation_p.E266K|NT5C1B_uc010exr.2_Missense_Mutation_p.E208K|NT5C1B_uc010yju.1_Missense_Mutation_p.E206K|NT5C1B_uc002rda.2_Missense_Mutation_p.E206K|NT5C1B_uc010yjv.1_Missense_Mutation_p.E283K|NT5C1B_uc010yjw.1_Missense_Mutation_p.E249K|NT5C1B_uc010exs.2_Missense_Mutation_p.E268K|NT5C1B_uc002rdb.1_Missense_Mutation_p.E58K	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	266					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TGCTGCTGCTCGGACAGAGAG	0.652													T	18765887	T	T	18765887	3	4	238	1	0	0	0	0	1	0	0	0	10686	893	31	2	1060	2	NT5C1B	2	18765887	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	17305940	18765887	224433486	10	16887											
APOB	338	broad.mit.edu	37	chr2	21231021	21231021	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtgtcttgatctcgttgcGcaggtcagcctgactagaga	12	10	3	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:21231021G>A	uc002red.2	-	26	8847	c.8719C>T	c.(8719-8721)CGC>TGC	p.R2907C		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2907					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATCTCGTTGCGCAGGTCAGCC	0.468													A	21231021	A	A	21231021	3	1	238	1	0	0	0	0	1	0	0	0	785	1087	38	1	4988	1	APOB	2	21231021	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	2465134	21231021	221968352	11	16888											
ALK	238	broad.mit.edu	37	chr2	29443572	29443572	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagactggttctcactcacCgggcgagggcgggtctctcg	14	12	3	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:29443572C>T	uc002rmy.2	-	23	4552	c.3645G>A	c.(3643-3645)CCG>CCA	p.P1215P	ALK_uc010ymo.1_Silent_p.P147P	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1215	Protein kinase.|Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TCTCACTCACCGGGCGAGGGC	0.612			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				T	29443572	T	T	29443572	2	4	238	1	0	0	0	0	0	0	0	1	525	666	23	2		2	ALK	2	29443572	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	8212551	29443572	213755801	12	16889											
POTEF	728378	broad.mit.edu	37	chr2	130877830	130877830	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtcttcatagcagagtcgtCgtggtctccagaagcgccca	11	12	3	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:130877830C>T	uc010fmh.2	-	3	659	c.259G>A	c.(259-261)GAC>AAC	p.D87N		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	87						cell cortex	ATP binding			skin(3)|ovary(2)	5						GCAGAGTCGTCGTGGTCTCCA	0.602													T	130877830	T	T	130877830	3	4	238	1	0	0	0	0	1	0	0	0	12265	884	31	2	3028	2	POTEF	2	130877830	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	101434258	130877830	112321543	13	16890											
POTEE	445582	broad.mit.edu	37	chr2	131976234	131976234	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgggcgcttctggagaccacGacgactctgctatgaagaca	12	11	2	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:131976234G>A	uc002tsn.2	+	1	311	c.259G>A	c.(259-261)GAC>AAC	p.D87N	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	87							ATP binding				0						TGGAGACCACGACGACTCTGC	0.602													A	131976234	A	A	131976234	3	1	238	1	0	0	0	0	1	0	0	0	12264	1058	37	2	261	2	POTEE	2	131976234	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	1098404	131976234	111223139	14	16891											
SCN1A	6323	broad.mit.edu	37	chr2	166850722	166850722	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatggtaaaataataatggcGtagagagatgagtttcagta	11	2	1	3	rs121917993		TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:166850722G>A	uc010zcz.1	-	25	4771	c.4753C>T	c.(4753-4755)CGC>TGC	p.R1585C		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1596	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TAATAATGGCGTAGAGAGATG	0.338													A	166850722	A	A	166850722	3	1	238	1	0	0	0	0	1	0	0	0	13914	1145	40	1	1251	1	SCN1A	2	166850722	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	34874488	166850722	76348651	15	16892											
TTN	7273	broad.mit.edu	37	chr2	179587016	179587016	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtctagcactagaagatgCtgttccaagtgggttggaag	14	6	1	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:179587016C>T	uc010zfg.1	-	74	18990	c.18766G>A	c.(18766-18768)GCA>ACA	p.A6256T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A2917T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7183							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTAGAAGATGCTGTTCCAAGT	0.408													T	179587016	T	T	179587016	3	4	238	1	0	0	0	0	1	0	0	0	16732	797	28	3	82175	3	TTN	2	179587016	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	12736294	179587016	63612357	16	16893											
UBE2E3	10477	broad.mit.edu	37	chr2	181846854	181846854	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggaccagcgagacccagccGctccagagcctgaagaacaa	11	15	0	4			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:181846854G>A	uc002unq.1	+	3	304	c.85G>A	c.(85-87)GCT>ACT	p.A29T	UBE2E3_uc002unr.1_Missense_Mutation_p.A29T|UBE2E3_uc010fri.1_Missense_Mutation_p.A29T	NM_182678	NP_872619	Q969T4	UB2E3_HUMAN	ubiquitin-conjugating enzyme E2E 3	29					protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|regulation of growth	cytoplasm|nucleolus	ATP binding|protein binding|ubiquitin-protein ligase activity			ovary(1)	1						AGACCCAGCCGCTCCAGAGCC	0.507													A	181846854	A	A	181846854	3	1	238	1	0	0	0	0	1	0	0	0	16851	1087	38	1	87	1	UBE2E3	2	181846854	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	2259838	181846854	61352519	17	16894											
HIBCH	26275	broad.mit.edu	37	chr2	191110923	191110923	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctcaagtataaaagacttgtCtcgatcaatcttagactgtt	6	8	4	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr2:191110923C>T	uc002uru.2	-	10	849	c.766G>A	c.(766-768)GAC>AAC	p.D256N	HIBCH_uc002urv.2_Missense_Mutation_p.D256N	NM_014362	NP_055177	Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-Coenzyme A hydrolase isoform	256					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			AAAGACTTGTCTCGATCAATC	0.254													T	191110923	T	T	191110923	3	4	238	1	0	0	0	0	1	0	0	0	7100	913	32	3	414	3	HIBCH	2	191110923	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	9264069	191110923	52088450	18	16895											
NBEAL2	23218	broad.mit.edu	37	chr3	47041457	47041457	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctggcaagatgtgctgaccCggctatatgtcctggaggct	14	10	0	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr3:47041457C>T	uc003cqp.2	+	27	4047	c.3868C>T	c.(3868-3870)CGG>TGG	p.R1290W	NBEAL2_uc010hjm.1_Intron|NBEAL2_uc010hjn.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1290							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TGTGCTGACCCGGCTATATGT	0.637													T	47041457	T	T	47041457	3	4	238	1	0	0	0	0	1	0	0	0	10189	643	23	2	3974	2	NBEAL2	3	47041457	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08		47041457	150980973	19	16896											
AMT	275	broad.mit.edu	37	chr3	49459869	49459870	+	Frame_Shift_Ins	INS	-	A	A													ccagacgggccaccacacttINSacagccctctgcatcgtcgc							TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr3:49459869_49459870insA	uc003cww.2	-	1	143_144	c.14_15insT	c.(13-15)GTAfs	p.V5fs	AMT_uc011bcn.1_5'UTR|AMT_uc003cwx.2_Frame_Shift_Ins_p.V5fs|AMT_uc011bco.1_Frame_Shift_Ins_p.V5fs|AMT_uc003cwy.2_5'UTR|AMT_uc011bcp.1_5'UTR|AMT_uc011bcq.1_Frame_Shift_Ins_p.V5fs|NICN1_uc003cwz.1_3'UTR	NM_000481	NP_000472	P48728	GCST_HUMAN	aminomethyltransferase isoform 1 precursor	5					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CCACCACACTTACAGCCCTCTG	0.639													A	49459870	A	A	49459869	7	5	238	1	0	1	1	0	0	0	0	0	589	1741	61	0	1260	0	AMT	3	49459869	Frame_Shift_Ins	INS	-	TCGA-32-4211-01A-01D-1353-08	2418412	49459869	148562561	20	16897											
CACNA2D2	9254	broad.mit.edu	37	chr3	50414925	50414925	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgggggtcagcctcttgatGtcattcagagccacgtcaat	11	10	5	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr3:50414925G>T	uc003daq.2	-	17	1637	c.1599C>A	c.(1597-1599)GAC>GAA	p.D533E	CACNA2D2_uc003dap.2_Missense_Mutation_p.D533E	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	533	Cache.|Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	GCCTCTTGATGTCATTCAGAG	0.597													T	50414925	T	T	50414925	3	4	238	1	0	0	0	0	1	0	0	0	2549	1368	48	5	1951	5	CACNA2D2	3	50414925	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	955056	50414925	147607505	21	16898											
NR1I2	8856	broad.mit.edu	37	chr3	119536025	119536025	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacccctttgctacgccccTcatgcaggagttgttcggca	9	15	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr3:119536025T>C	uc003edj.2	+	9	3110	c.1271T>C	c.(1270-1272)CTC>CCC	p.L424P	NR1I2_uc003edi.2_Missense_Mutation_p.L387P|NR1I2_uc003edk.2_Missense_Mutation_p.L463P|NR1I2_uc003edl.2_Missense_Mutation_p.L312P	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	424	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	GCTACGCCCCTCATGCAGGAG	0.622													C	119536025	C	C	119536025	3	2	238	1	0	0	0	0	1	0	0	0	10620	1551	54	4	1422	4	NR1I2	3	119536025	Missense_Mutation	SNP	T	TCGA-32-4211-01A-01D-1353-08	69121100	119536025	78486405	22	16899											
CSTA	1475	broad.mit.edu	37	chr3	122060340	122060340	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagtattcaaaagtcttcccGgacaaaatgaggacttggta	9	7	2	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr3:122060340G>A	uc003eex.2	+	3	352	c.223G>A	c.(223-225)GGA>AGA	p.G75R		NM_005213	NP_005204	P01040	CYTA_HUMAN	cystatin A	75					keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|nucleus	cysteine-type endopeptidase inhibitor activity|protease binding|protein binding, bridging|structural molecule activity				0				GBM - Glioblastoma multiforme(114;0.155)		AAGTCTTCCCGGACAAAATGA	0.378													A	122060340	A	A	122060340	3	1	238	1	0	0	0	0	1	0	0	0	3981	1117	39	2	233	2	CSTA	3	122060340	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	2524315	122060340	75962090	23	16900											
CLSTN2	64084	broad.mit.edu	37	chr3	140178466	140178466	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagatgatcttcaagtttgaCggcaggcagggtgccaaagt	14	7	2	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr3:140178466C>T	uc003etn.2	+	7	1267	c.1077C>T	c.(1075-1077)GAC>GAT	p.D359D	CLSTN2_uc003etm.2_Silent_p.D359D	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	359	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TCAAGTTTGACGGCAGGCAGG	0.577										HNSCC(16;0.037)			T	140178466	T	T	140178466	2	4	238	1	0	0	0	0	0	0	0	1	3562	535	19	1		1	CLSTN2	3	140178466	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	18118126	140178466	57843964	24	16901											
ETV5	2119	broad.mit.edu	37	chr3	185766628	185766628	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgggtcacagacaaatttgtAgacgtatcgctctccagcca	9	11	2	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr3:185766628A>G	uc003fpz.2	-	13	1580	c.1333T>C	c.(1333-1335)TAC>CAC	p.Y445H	ETV5_uc003fpy.2_Missense_Mutation_p.Y487H	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	445	ETS.				cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding	p.Y445C(2)		ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			ACAAATTTGTAGACGTATCGC	0.562			T	TMPRSS2|SCL45A3	Prostate 								G	185766628	G	G	185766628	3	3	238	1	0	0	0	0	1	0	0	0	5282	420	15	4	203	4	ETV5	3	185766628	Missense_Mutation	SNP	A	TCGA-32-4211-01A-01D-1353-08	45588162	185766628	12255802	25	16902											
SST	6750	broad.mit.edu	37	chr3	187387016	187387016	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttccagggcatcattctccGtctggttgggttcagacagc	12	11	4	1	rs149673471		TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr3:187387016G>A	uc003frn.2	-	2	310	c.188C>T	c.(187-189)ACG>ATG	p.T63M		NM_001048	NP_001039	P61278	SMS_HUMAN	somatostatin preproprotein	63					digestion|G-protein coupled receptor protein signaling pathway|induction of apoptosis by hormones|negative regulation of cell proliferation|response to nutrient|synaptic transmission	extracellular space	hormone activity			pancreas(1)	1	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.00444)	Bromocriptine(DB01200)|Cysteamine(DB00847)	ATCATTCTCCGTCTGGTTGGG	0.517													A	187387016	A	A	187387016	3	1	238	1	0	0	0	0	1	0	0	0	15195	1145	40	1	166	1	SST	3	187387016	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	1620388	187387016	10635414	26	16903											
ZNF718	255403	broad.mit.edu	37	chr4	155819	155819	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagaaaattcacactgtagaTaaaccctacaaatgtaaaga	5	7	1	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr4:155819T>G	uc003fzt.3	+	8	1477	c.1344T>G	c.(1342-1344)GAT>GAG	p.D448E	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_3'UTR	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		ACACTGTAGATAAACCCTACA	0.353													G	155819	G	G	155819	3	3	238	1	0	0	0	0	1	0	0	0	18117	1403	49	5	1358	5	ZNF718	4	155819	Missense_Mutation	SNP	T	TCGA-32-4211-01A-01D-1353-08		155819	190998457	27	16904											
FGFRL1	53834	broad.mit.edu	37	chr4	1018886	1018886	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcaccgcccgccggggacGgcccgcgaccgcagcggaga	18	17	0	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr4:1018886G>A	uc003gce.2	+	7	1427	c.1266G>A	c.(1264-1266)ACG>ACA	p.T422T	FGFRL1_uc003gcf.2_Silent_p.T422T|FGFRL1_uc003gcg.2_Silent_p.T422T|FGFRL1_uc010ibo.2_Silent_p.T422T	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	422	Cytoplasmic (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CGCCGGGGACGGCCCGCGACC	0.731													A	1018886	A	A	1018886	2	1	238	1	0	0	0	0	0	0	0	1	5869	1103	39	2		2	FGFRL1	4	1018886	Silent	SNP	G	TCGA-32-4211-01A-01D-1353-08	863067	1018886	190135390	28	16905											
TLR6	10333	broad.mit.edu	37	chr4	38829218	38829218	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggtatgttcctggccctgCgccgagtctgggtccactgg	15	12	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr4:38829218C>T	uc003gtm.2	-	1	1943	c.1877G>A	c.(1876-1878)CGC>CAC	p.R626H	TLR6_uc010ifg.1_Missense_Mutation_p.R626H	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	626	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						CCTGGCCCTGCGCCGAGTCTG	0.502													T	38829218	T	T	38829218	3	4	238	1	0	0	0	0	1	0	0	0	15952	768	27	1	517	1	TLR6	4	38829218	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	37810332	38829218	152325058	29	16906											
PITX2	5308	broad.mit.edu	37	chr4	111553638	111553638	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acggccgccggctgcacgccTgggccacgcgcgcgcccgcc	15	21	0	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr4:111553638T>A	uc003iad.2	-	3	629	c.47_splice	c.e3-1	p.G16_splice	PITX2_uc003iae.2_Intron|PITX2_uc010iml.2_Splice_Site|PITX2_uc003iaf.2_Splice_Site_p.G16_splice	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2						determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		GCTGCACGCCTGGGCCACGCG	0.687													A	111553638	A	A	111553638	5	1	238	1	0	0	0	0	0	0	1	0	11955	1594	55	5	1129	5	PITX2	4	111553638	Splice_Site	SNP	T	TCGA-32-4211-01A-01D-1353-08	72724420	111553638	79600638	30	16907											
ANK2	287	broad.mit.edu	37	chr4	114251595	114251595	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcctggccagtcgcctgatcGaagttggaccttctggtgct	13	12	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr4:114251595G>A	uc003ibe.3	+	27	3194	c.3094G>A	c.(3094-3096)GAA>AAA	p.E1032K	ANK2_uc003ibd.3_Missense_Mutation_p.E1023K|ANK2_uc003ibf.3_Missense_Mutation_p.E1032K|ANK2_uc011cgc.1_Missense_Mutation_p.E241K|ANK2_uc003ibg.3_Missense_Mutation_p.E60K|ANK2_uc003ibc.2_Missense_Mutation_p.E1008K|ANK2_uc011cgb.1_Missense_Mutation_p.E1047K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCGCCTGATCGAAGTTGGACC	0.532													A	114251595	A	A	114251595	3	1	238	1	0	0	0	0	1	0	0	0	621	1059	37	2	3265	2	ANK2	4	114251595	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	2697957	114251595	76902681	31	16908											
GPM6A	2823	broad.mit.edu	37	chr4	176594942	176594942	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agcaaaatgccatacacaaaGaacgcagctgcgatgccgta	9	11	0	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr4:176594942G>C	uc003iuf.2	-	3	1080	c.276C>G	c.(274-276)TTC>TTG	p.F92L	GPM6A_uc011ckj.1_Missense_Mutation_p.F85L|GPM6A_uc003iug.2_Missense_Mutation_p.F92L|GPM6A_uc003iuh.2_Missense_Mutation_p.F81L	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	92	Helical; (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		CATACACAAAGAACGCAGCTG	0.418													C	176594942	C	C	176594942	3	2	238	1	0	0	0	0	1	0	0	0	6615	933	33	5	580	5	GPM6A	4	176594942	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	62343347	176594942	14559334	32	16909											
DNAH5	1767	broad.mit.edu	37	chr5	13809274	13809274	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaggtattcctgggtacgcGtgttccagtgcgtccatgta	12	10	0	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr5:13809274G>A	uc003jfd.2	-	46	7673	c.7631C>T	c.(7630-7632)ACG>ATG	p.T2544M		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2544					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTGGGTACGCGTGTTCCAGTG	0.438									Kartagener_syndrome				A	13809274	A	A	13809274	3	1	238	1	0	0	0	0	1	0	0	0	4604	1145	40	1	6379	1	DNAH5	5	13809274	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08		13809274	167105986	33	16910											
GRAMD3	65983	broad.mit.edu	37	chr5	125822670	125822670	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtggacacccataatactgaGtaagacgattgcctctagct	9	10	1	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr5:125822670G>T	uc003ktu.2	+	12	1593	c.1163_splice	c.e12+1	p.E388_splice	GRAMD3_uc011cwt.1_Splice_Site_p.E403_splice|GRAMD3_uc011cwv.1_Splice_Site_p.E396_splice|GRAMD3_uc011cww.1_Splice_Site_p.E284_splice|GRAMD3_uc011cwx.1_Splice_Site|GRAMD3_uc011cwy.1_Splice_Site_p.E279_splice|GRAMD3_uc011cwz.1_Splice_Site_p.E372_splice	NM_023927	NP_076416	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3 isoform 2											central_nervous_system(1)	1		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		ATAATACTGAGTAAGACGATT	0.403													T	125822670	T	T	125822670	5	4	238	1	0	0	0	0	0	0	1	0	6751	1043	36	5	1424	5	GRAMD3	5	125822670	Splice_Site	SNP	G	TCGA-32-4211-01A-01D-1353-08	112013396	125822670	55092590	34	16911											
ADAM19	8728	broad.mit.edu	37	chr5	156916128	156916128	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctttcgcttgccctggggCgtctgcagcttgaaagttgg	13	11	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr5:156916128C>T	uc003lwz.2	-	20	2371	c.2307G>A	c.(2305-2307)ACG>ACA	p.T769T	ADAM19_uc003lww.1_Silent_p.T502T|ADAM19_uc003lwy.2_Silent_p.T368T|ADAM19_uc011ddr.1_Silent_p.T700T	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	769	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGCCCTGGGGCGTCTGCAGCT	0.453													T	156916128	T	T	156916128	2	4	238	1	0	0	0	0	0	0	0	1	240	755	27	1		1	ADAM19	5	156916128	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	31093458	156916128	23999132	35	16912											
IRF4	3662	broad.mit.edu	37	chr6	398917	398917	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agccaagcataaggtctgccGaagccttggcgttctcaggt	12	11	2	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:398917G>A	uc003msz.3	+	6	840	c.727G>A	c.(727-729)GAA>AAA	p.E243K	IRF4_uc010jne.1_Missense_Mutation_p.E243K|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.E242K|IRF4_uc003mtc.1_Missense_Mutation_p.E73K	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	243					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		AAGGTCTGCCGAAGCCTTGGC	0.592			T	IGH@	MM 								A	398917	A	A	398917	3	1	238	1	0	0	0	0	1	0	0	0	7832	1059	37	2	745	2	IRF4	6	398917	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08		398917	170716150	36	16913											
F13A1	2162	broad.mit.edu	37	chr6	6225003	6225003	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtattccaatagaatgtcaaCgcttccagtccaggccgatg	9	11	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:6225003C>T	uc003mwv.2	-	7	1012	c.889G>A	c.(889-891)GTT>ATT	p.V297I	F13A1_uc011dib.1_Missense_Mutation_p.V234I	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	297					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	AGAATGTCAACGCTTCCAGTC	0.488													T	6225003	T	T	6225003	3	4	238	1	0	0	0	0	1	0	0	0	5340	536	19	1	1345	1	F13A1	6	6225003	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	5826086	6225003	164890064	37	16914											
JARID2	3720	broad.mit.edu	37	chr6	15504806	15504806	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtttcagcaaggagcctGccccagccgaaatcgaggtg	13	11	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:15504806G>T	uc003nbj.2	+	9	2768	c.2524G>T	c.(2524-2526)GCC>TCC	p.A842S	JARID2_uc011div.1_Missense_Mutation_p.A670S|JARID2_uc011diw.1_Missense_Mutation_p.A804S	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	842					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CAAGGAGCCTGCCCCAGCCGA	0.522													T	15504806	T	T	15504806	3	4	238	1	0	0	0	0	1	0	0	0	7945	1319	46	5	2558	5	JARID2	6	15504806	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	9279803	15504806	155610261	38	16915											
KIF13A	63971	broad.mit.edu	37	chr6	17800257	17800257	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcaaggctcccactttcacTggaattctccgaagagtcat	7	12	4	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:17800257T>G	uc003ncg.3	-	21	2647	c.2542A>C	c.(2542-2544)AGT>CGT	p.S848R	KIF13A_uc003ncf.2_Missense_Mutation_p.S848R|KIF13A_uc003nch.3_Missense_Mutation_p.S848R|KIF13A_uc003nci.3_Missense_Mutation_p.S848R	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	848					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CCACTTTCACTGGAATTCTCC	0.537													G	17800257	G	G	17800257	3	3	238	1	0	0	0	0	1	0	0	0	8274	1580	55	5	2976	5	KIF13A	6	17800257	Missense_Mutation	SNP	T	TCGA-32-4211-01A-01D-1353-08	2295451	17800257	153314810	39	16916											
ABCC10	89845	broad.mit.edu	37	chr6	43415637	43415637	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagggcgagtgctgctggaCggcgtggacaccagccagct	16	12	1	0	rs144509707		TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:43415637C>T	uc003ouy.1	+	18	4136	c.3921C>T	c.(3919-3921)GAC>GAT	p.D1307D	ABCC10_uc003ouz.1_Silent_p.D1279D|ABCC10_uc010jyo.1_Silent_p.D413D	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1307	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TGCTGCTGGACGGCGTGGACA	0.632													T	43415637	T	T	43415637	2	4	238	1	0	0	0	0	0	0	0	1	50	535	19	1		1	ABCC10	6	43415637	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	25615380	43415637	127699430	40	16917											
ENPP4	22875	broad.mit.edu	37	chr6	46111073	46111073	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	tccatttctagctgcccacgGacctgcatttcacaaaggct	7	14	2	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:46111073G>C	uc003oxy.2	+	4	1317	c.1058G>C	c.(1057-1059)GGA>GCA	p.G353A		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	353	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						GCTGCCCACGGACCTGCATTT	0.388													C	46111073	C	C	46111073	3	2	238	1	0	0	0	0	1	0	0	0	5132	1174	41	5	1068	5	ENPP4	6	46111073	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	2695436	46111073	125003994	41	16918											
SYNJ2	8871	broad.mit.edu	37	chr6	158438287	158438287	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtatggcaagctcacggacgCgtacggctgcctgggggagc	17	11	1	0	rs143362296	byFrequency	TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:158438287C>T	uc003qqx.1	+	2	254	c.179C>T	c.(178-180)GCG>GTG	p.A60V	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Missense_Mutation_p.A60V|SYNJ2_uc003qqy.1_5'UTR|SYNJ2_uc011efn.1_5'Flank|SYNJ2_uc010kjo.1_5'Flank	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	60							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CTCACGGACGCGTACGGCTGC	0.602													T	158438287	T	T	158438287	3	4	238	1	0	0	0	0	1	0	0	0	15450	768	27	1	185	1	SYNJ2	6	158438287	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	112327214	158438287	12676780	42	16919											
FNDC1	84624	broad.mit.edu	37	chr6	159653361	159653361	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctggcttttccctggccaCgcagccccgcccaggggcgc	13	19	0	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:159653361C>T	uc010kjv.2	+	11	2017	c.1817C>T	c.(1816-1818)ACG>ATG	p.T606M	FNDC1_uc010kjw.1_Missense_Mutation_p.T491M	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	606						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TCCCTGGCCACGCAGCCCCGC	0.706													T	159653361	T	T	159653361	3	4	238	1	0	0	0	0	1	0	0	0	5968	536	19	1	1859	1	FNDC1	6	159653361	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	1215074	159653361	11461706	43	16920											
RPS6KA2	6196	broad.mit.edu	37	chr6	166844032	166844032	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtatctctgccggaggatgCggtccaggagctccccacca	12	14	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:166844032C>T	uc003qvb.1	-	16	1709	c.1490G>A	c.(1489-1491)CGC>CAC	p.R497H	RPS6KA2_uc011ego.1_Missense_Mutation_p.R408H|RPS6KA2_uc010kkl.1_Missense_Mutation_p.R408H|RPS6KA2_uc003qvc.1_Missense_Mutation_p.R505H|RPS6KA2_uc003qvd.1_Missense_Mutation_p.R522H	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	497	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CCGGAGGATGCGGTCCAGGAG	0.592													T	166844032	T	T	166844032	3	4	238	1	0	0	0	0	1	0	0	0	13651	768	27	1	735	1	RPS6KA2	6	166844032	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	7190671	166844032	4271035	44	16921											
TTLL2	83887	broad.mit.edu	37	chr6	167754158	167754158	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagatataaatgtgatctccGcatctatgtttgtgttactg	8	7	2	2	rs34053826		TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr6:167754158G>A	uc003qvs.1	+	3	858	c.770G>A	c.(769-771)CGC>CAC	p.R257H	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	257	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGTGATCTCCGCATCTATGTT	0.358													A	167754158	A	A	167754158	3	1	238	1	0	0	0	0	1	0	0	0	16724	1087	38	1	780	1	TTLL2	6	167754158	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	910126	167754158	3360909	45	16922											
GPR141	353345	broad.mit.edu	37	chr7	37780661	37780661	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctatcccaccaggagttctgGgctcagctgaaaaacctatt	8	12	2	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr7:37780661G>A	uc003tfm.1	+	1	666	c.666G>A	c.(664-666)TGG>TGA	p.W222*	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	222	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						AGGAGTTCTGGGCTCAGCTGA	0.433													A	37780661	A	A	37780661	4	1	238	1	0	0	0	0	0	1	0	0	6649	1241	43	3	668	3	GPR141	7	37780661	Nonsense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08		37780661	121358002	46	16923											
C7orf57	136288	broad.mit.edu	37	chr7	48092478	48092478	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtccccaggatgcagccaggCtccaggatgcagaggcttct	13	13	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr7:48092478C>A	uc003toh.3	+	7	999	c.787C>A	c.(787-789)CTC>ATC	p.L263I	C7orf57_uc003toi.3_Missense_Mutation_p.L121I	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	263										ovary(1)	1						TGCAGCCAGGCTCCAGGATGC	0.572													A	48092478	A	A	48092478	3	1	238	1	0	0	0	0	1	0	0	0	2404	797	28	5	809	5	C7orf57	7	48092478	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	10311817	48092478	111046185	47	16924											
POM121	9883	broad.mit.edu	37	chr7	72413425	72413425	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccgctcccatcatatccgGgagccaacccccagcccgca	7	22	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr7:72413425G>A	uc003twk.2	+	11	2893	c.2893G>A	c.(2893-2895)GGA>AGA	p.G965R	POM121_uc003twj.2_Missense_Mutation_p.G700R|POM121_uc010lam.1_Missense_Mutation_p.G700R	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	965	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				ATCATATCCGGGAGCCAACCC	0.647													A	72413425	A	A	72413425	3	1	238	1	0	0	0	0	1	0	0	0	12239	1233	43	3	2136	3	POM121	7	72413425	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	24320947	72413425	86725238	48	16925											
GNAT3	346562	broad.mit.edu	37	chr7	80088106	80088106	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtgggaataaatttccttatCttctttttttaaattcaggt	6	5	3	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr7:80088106C>T	uc011kgu.1	-	8	946	c.946G>A	c.(946-948)GAT>AAT	p.D316N	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	316					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						ATTTCCTTATCTTCTTTTTTT	0.323													T	80088106	T	T	80088106	3	4	238	1	0	0	0	0	1	0	0	0	6513	913	32	3	120	3	GNAT3	7	80088106	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	7674681	80088106	79050557	49	16926											
DLX6	1750	broad.mit.edu	37	chr7	96637111	96637111	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cccttccagagagagccgaaCtggcagcttccttaggactg	11	13	0	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr7:96637111C>G	uc003uom.2	+	3	514	c.514C>G	c.(514-516)CTG>GTG	p.L172V	DLX6AS_uc003uol.2_Intron|DLX6AS_uc010lfo.1_Intron	NM_005222	NP_005213	P56179	DLX6_HUMAN	distal-less homeobox 6	82	Homeobox.				nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GAGAGCCGAACTGGCAGCTTC	0.532													G	96637111	G	G	96637111	3	3	238	1	0	0	0	0	1	0	0	0	4575	564	20	5	604	5	DLX6	7	96637111	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	16549005	96637111	62501552	50	16927											
SLC26A3	1811	broad.mit.edu	37	chr7	107434196	107434196	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaattttaccttgtagtaCggccacaatccctgtgctga	7	10	0	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr7:107434196C>T	uc003ver.2	-	3	473	c.262G>A	c.(262-264)GTA>ATA	p.V88I	SLC26A3_uc003ves.2_Missense_Mutation_p.V53I	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	88	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						ccttGTAGTACGGCCACAATC	0.254													T	107434196	T	T	107434196	3	4	238	1	0	0	0	0	1	0	0	0	14518	536	19	1	2108	1	SLC26A3	7	107434196	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	10797085	107434196	51704467	51	16928											
ATP6V0A4	50617	broad.mit.edu	37	chr7	138432176	138432176	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caatggacactcacctcattGtctgtcttctgggagagcaa	9	11	5	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr7:138432176G>T	uc003vuf.2	-	12	1552	c.1314C>A	c.(1312-1314)GAC>GAA	p.D438E	ATP6V0A4_uc003vug.2_Missense_Mutation_p.D438E|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.D438E	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	438	Lumenal (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						TCACCTCATTGTCTGTCTTCT	0.428													T	138432176	T	T	138432176	3	4	238	1	0	0	0	0	1	0	0	0	1170	1368	48	5	1248	5	ATP6V0A4	7	138432176	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	30997980	138432176	20706487	52	16929											
OR2A12	346525	broad.mit.edu	37	chr7	143792752	143792752	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgtcaaatcatgtccgtattCaaattggcctgtgctgacac	8	10	3	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr7:143792752C>T	uc011kty.1	+	1	552	c.552C>T	c.(550-552)TTC>TTT	p.F184F		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TGTCCGTATTCAAATTGGCCT	0.493													T	143792752	T	T	143792752	2	4	238	1	0	0	0	0	0	0	0	1	10975	825	29	3		3	OR2A12	7	143792752	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	5360576	143792752	15345911	53	16930											
OR2A7	401427	broad.mit.edu	37	chr7	143956670	143956670	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catctgaatccttgggccaaCgggaaatcccagtaggagga	12	10	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr7:143956670C>T	uc011kuc.1	-	1	52	c.52G>A	c.(52-54)GTT>ATT	p.V18I	OR2A9P_uc003wec.1_Intron|OR2A7_uc003wef.2_3'UTR	NM_001005328	NP_001005328	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.14)					CTTGGGCCAACGGGAAATCCC	0.498													T	143956670	T	T	143956670	3	4	238	1	0	0	0	0	1	0	0	0	10982	536	19	1	883	1	OR2A7	7	143956670	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	163918	143956670	15181993	54	16931											
CYP7A1	1581	broad.mit.edu	37	chr8	59409723	59409723	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcagtggtatttccatccatCgggtcaatgcttctgtgccc	9	12	3	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr8:59409723C>T	uc003xtm.3	-	3	411	c.348G>A	c.(346-348)CCG>CCA	p.P116P		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	116					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TTCCATCCATCGGGTCAATGC	0.418									Neonatal_Giant_Cell_Hepatitis				T	59409723	T	T	59409723	2	4	238	1	0	0	0	0	0	0	0	1	4196	871	31	2		2	CYP7A1	8	59409723	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08		59409723	86954299	55	16932											
TRPA1	8989	broad.mit.edu	37	chr8	72948586	72948586	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caattgctccacattgccacTgcagatgagctggtatttca	8	11	1	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr8:72948586T>A	uc003xza.2	-	21	2667	c.2492A>T	c.(2491-2493)CAG>CTG	p.Q831L	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	831	Helical; Name=4; (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	ACATTGCCACTGCAGATGAGC	0.353													A	72948586	A	A	72948586	3	1	238	1	0	0	0	0	1	0	0	0	16574	1580	55	5	895	5	TRPA1	8	72948586	Missense_Mutation	SNP	T	TCGA-32-4211-01A-01D-1353-08	13538863	72948586	73415436	56	16933											
TMEM70	54968	broad.mit.edu	37	chr8	74888704	74888704	+	Frame_Shift_Del	DEL	T	-	-													ttcgggagccgcgcgccttcTccggcgtccgggtcgagcgc							TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr8:74888704delT	uc003yab.2	+	1	275	c.188delT	c.(187-189)CTCfs	p.L63fs	TMEM70_uc003yac.2_Frame_Shift_Del_p.L63fs	NM_017866	NP_060336	Q9BUB7	TMM70_HUMAN	transmembrane protein 70 isoform a	63					mitochondrial proton-transporting ATP synthase complex assembly	integral to mitochondrial membrane|mitochondrial inner membrane				ovary(1)	1	Breast(64;0.0311)		Epithelial(68;0.0186)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0564)			GCGCGCCTTCTCCGGCGTCCG	0.766													-	74888704	-	-	74888704	7	5	238	1	0	1	0	1	0	0	0	0	16196	1551	54	0	190	0	TMEM70	8	74888704	Frame_Shift_Del	DEL	T	TCGA-32-4211-01A-01D-1353-08	1940118	74888704	71475318	57	16934											
ZNF623	9831	broad.mit.edu	37	chr8	144733275	144733275	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtaaggaatgtgggaaagcGtttctccagaaagcccatct	11	8	2	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr8:144733275G>A	uc003yzd.2	+	1	1322	c.1233G>A	c.(1231-1233)GCG>GCA	p.A411A	ZNF623_uc011lkp.1_Silent_p.A371A|ZNF623_uc003yzc.2_Silent_p.A371A	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	411	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GTGGGAAAGCGTTTCTCCAGA	0.478													A	144733275	A	A	144733275	2	1	238	1	0	0	0	0	0	0	0	1	18044	1132	40	1		1	ZNF623	8	144733275	Silent	SNP	G	TCGA-32-4211-01A-01D-1353-08	69844571	144733275	1630747	58	16935											
KIAA0020	9933	broad.mit.edu	37	chr9	2829880	2829880	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacgatggctgatgcttccGcatgccgcagcatcttcctc	9	16	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr9:2829880G>A	uc003zhp.1	-	8	842	c.746C>T	c.(745-747)GCG>GTG	p.A249V	KIAA0020_uc010mhc.1_Missense_Mutation_p.A248V|KIAA0020_uc003zhq.1_Missense_Mutation_p.A248V	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	249	Pumilio 3.|PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		TGATGCTTCCGCATGCCGCAG	0.443													A	2829880	A	A	2829880	3	1	238	1	0	0	0	0	1	0	0	0	8152	1087	38	1	1244	1	KIAA0020	9	2829880	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08		2829880	138383551	59	16936											
OR1L4	254973	broad.mit.edu	37	chr9	125486747	125486747	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacctacattccctgttccGcgtgctacttatgtctcgct	6	16	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr9:125486747G>A	uc004bmu.1	+	1	479	c.479G>A	c.(478-480)CGC>CAC	p.R160H		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	160	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCCTGTTCCGCGTGCTACTT	0.478													A	125486747	A	A	125486747	3	1	238	1	0	0	0	0	1	0	0	0	10965	1087	38	1	481	1	OR1L4	9	125486747	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	122656867	125486747	15726684	60	16937											
ARMC3	219681	broad.mit.edu	37	chr10	23235138	23235138	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttaatgcttaattctccagaAgaggaaattttggctaaagc	8	6	1	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr10:23235138A>G	uc001irm.3	+	3	197	c.114A>G	c.(112-114)GAA>GAG	p.E38E	ARMC3_uc010qcv.1_Silent_p.E38E|ARMC3_uc010qcw.1_Intron	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	38	ARM 1.						binding				0						ATTCTCCAGAAGAGGAAATTT	0.303													G	23235138	G	G	23235138	2	3	238	1	0	0	0	0	0	0	0	1	952	69	3	4		4	ARMC3	10	23235138	Silent	SNP	A	TCGA-32-4211-01A-01D-1353-08		23235138	112299609	61	16938											
ARMC4	55130	broad.mit.edu	37	chr10	28283881	28283881	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgattcaaatgctgagggcGccaaacttgtgttccattca	9	10	2	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr10:28283881G>A	uc009xky.2	-	2	289	c.191C>T	c.(190-192)GCG>GTG	p.A64V	ARMC4_uc001itz.2_Missense_Mutation_p.A64V	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	64							binding			ovary(4)|skin(2)	6						TGCTGAGGGCGCCAAACTTGT	0.358													A	28283881	A	A	28283881	3	1	238	1	0	0	0	0	1	0	0	0	953	1087	38	1	3019	1	ARMC4	10	28283881	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	5048743	28283881	107250866	62	16939											
DNTT	1791	broad.mit.edu	37	chr10	98084132	98084132	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caaaagcctgaaatttacacGaatgcagaaagcaggtaaat	8	7	0	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr10:98084132G>A	uc001kmf.2	+	6	1030	c.860G>A	c.(859-861)CGA>CAA	p.R287Q	DNTT_uc001kmg.2_Missense_Mutation_p.R287Q	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	287	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AAATTTACACGAATGCAGAAA	0.453													A	98084132	A	A	98084132	3	1	238	1	0	0	0	0	1	0	0	0	4680	1058	37	2	882	2	DNTT	10	98084132	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	69800251	98084132	37450615	63	16940											
ITPRIP	85450	broad.mit.edu	37	chr10	106075308	106075308	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcttccagcaagtcatccaCgaagccttccaggaactccc	8	16	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr10:106075308C>T	uc001kye.2	-	2	575	c.502G>A	c.(502-504)GTG>ATG	p.V168M	ITPRIP_uc001kyf.2_Missense_Mutation_p.V168M|ITPRIP_uc001kyg.2_Missense_Mutation_p.V168M	NM_033397	NP_203755	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-triphosphate receptor interacting	168						plasma membrane					0						AAGTCATCCACGAAGCCTTCC	0.622													T	106075308	T	T	106075308	3	4	238	1	0	0	0	0	1	0	0	0	7923	536	19	1	1145	1	ITPRIP	10	106075308	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	7991176	106075308	29459439	64	16941											
MRGPRX2	117194	broad.mit.edu	37	chr11	19077216	19077216	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttccagatccataatattAggaaccactgaatgccaaag	6	11	0	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr11:19077216A>G	uc001mph.2	-	2	822	c.734T>C	c.(733-735)CTA>CCA	p.L245P		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	245	Helical; Name=6; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						CCATAATATTAGGAACCACTG	0.498													G	19077216	G	G	19077216	3	3	238	1	0	0	0	0	1	0	0	0	9767	420	15	4	262	4	MRGPRX2	11	19077216	Missense_Mutation	SNP	A	TCGA-32-4211-01A-01D-1353-08		19077216	115929300	65	16942											
C11orf94	143678	broad.mit.edu	37	chr11	45928455	45928455	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaagtggctgcgagagttccAggggggcggaaaatgcctca	16	8	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr11:45928455A>G	uc001nbs.3	-	2	177	c.140T>C	c.(139-141)CTG>CCG	p.L47P		NM_001080446	NP_001073915	C9JXX5	CK094_HUMAN	hypothetical protein LOC143678	47						extracellular region					0						CGAGAGTTCCAGGGGGGCGGA	0.617													G	45928455	G	G	45928455	3	3	238	1	0	0	0	0	1	0	0	0	1673	188	7	4	164	4	C11orf94	11	45928455	Missense_Mutation	SNP	A	TCGA-32-4211-01A-01D-1353-08	26851239	45928455	89078061	66	16943											
SMTNL1	219537	broad.mit.edu	37	chr11	57314061	57314061	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agttcttccctgacgcctttGactacgcagagctggatccc	9	14	1	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr11:57314061G>C	uc009ymh.1	+	7	1330	c.1330G>C	c.(1330-1332)GAC>CAC	p.D444H		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	426										ovary(1)	1						TGACGCCTTTGACTACGCAGA	0.587													C	57314061	C	C	57314061	3	2	238	1	0	0	0	0	1	0	0	0	14815	1290	45	5	1356	5	SMTNL1	11	57314061	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	11385606	57314061	77692455	67	16944											
NUMA1	4926	broad.mit.edu	37	chr11	71729532	71729532	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagggctaggcggtcaatgCgctgctgcatcatggctatc	14	11	2	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr11:71729532C>T	uc001orl.1	-	11	942	c.770G>A	c.(769-771)CGC>CAC	p.R257H	NUMA1_uc009ysw.1_5'Flank|NUMA1_uc001ork.1_Missense_Mutation_p.R257H|NUMA1_uc001orm.1_Missense_Mutation_p.R257H|NUMA1_uc001orn.2_5'Flank|NUMA1_uc009ysx.1_Missense_Mutation_p.R257H|NUMA1_uc001oro.1_Missense_Mutation_p.R257H|NUMA1_uc009ysy.1_Missense_Mutation_p.R257H|NUMA1_uc001orp.2_Missense_Mutation_p.R257H|NUMA1_uc001orq.2_Missense_Mutation_p.R257H	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	257	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						GCGGTCAATGCGCTGCTGCAT	0.557			T	RARA	APL								T	71729532	T	T	71729532	3	4	238	1	0	0	0	0	1	0	0	0	10750	768	27	1	5645	1	NUMA1	11	71729532	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	14415471	71729532	63276984	68	16945											
ADAMTS20	80070	broad.mit.edu	37	chr12	43846340	43846340	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cactgtatcttggaagccacCtcacattagagggaatgcca	9	11	2	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr12:43846340C>G	uc010skx.1	-	13	1919	c.1919G>C	c.(1918-1920)AGG>ACG	p.R640T		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	640	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TGGAAGCCACCTCACATTAGA	0.368													G	43846340	G	G	43846340	3	3	238	1	0	0	0	0	1	0	0	0	266	681	24	5	3920	5	ADAMTS20	12	43846340	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08		43846340	90005555	69	16946											
DCTN2	10540	broad.mit.edu	37	chr12	57939864	57939864	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtcgctagtttcataaacatCtggctcattcctggcctgca	8	12	3	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr12:57939864C>T	uc001som.1	-	2	184	c.52G>A	c.(52-54)GAT>AAT	p.D18N	DCTN2_uc009zpu.1_Missense_Mutation_p.D18N|DCTN2_uc009zpv.1_5'UTR|DCTN2_uc009zpw.1_5'UTR|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_5'UTR|DCTN2_uc001sop.1_5'UTR|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Missense_Mutation_p.D18N	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	18					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1						TCATAAACATCTGGCTCATTC	0.517													T	57939864	T	T	57939864	3	4	238	1	0	0	0	0	1	0	0	0	4307	913	32	3	1206	3	DCTN2	12	57939864	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	14093524	57939864	75912031	70	16947											
TMTC2	160335	broad.mit.edu	37	chr12	83251229	83251229	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctggggctggttcctggggtCaggactgtgcgcaggatgca	18	9	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr12:83251229C>G	uc001szt.2	+	2	956	c.524C>G	c.(523-525)TCA>TGA	p.S175*	TMTC2_uc001szr.1_Nonsense_Mutation_p.S175*|TMTC2_uc001szs.1_Nonsense_Mutation_p.S175*|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	175	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						TTCCTGGGGTCAGGACTGTGC	0.507													G	83251229	G	G	83251229	4	3	238	1	0	0	0	0	0	1	0	0	16258	838	29	5	530	5	TMTC2	12	83251229	Nonsense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	25311365	83251229	50600666	71	16948											
TMTC2	160335	broad.mit.edu	37	chr12	83251308	83251308	+	Silent	SNP	C	G	G													gtttcagcagtttatgatgtCtttgtctttcacaggctgaa							TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr12:83251308C>G	uc001szt.2	+	2	1035	c.603C>G	c.(601-603)GTC>GTG	p.V201V	TMTC2_uc001szr.1_Silent_p.V201V|TMTC2_uc001szs.1_Silent_p.V201V|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	201	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						TTTATGATGTCTTTGTCTTTC	0.443													G	83251308	G	G	83251308	2	3	238	1	0	0	0	0	0	0	0	1	16258	900	32	5		5	TMTC2	12	83251308	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	79	83251308	50600587	72	16949	21	2									
TMTC2	160335	broad.mit.edu	37	chr12	83251314	83251314	+	Silent	SNP	C	G	G													gcagtttatgatgtctttgtCtttcacaggctgaaaataaa					rs138847027		TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr12:83251314C>G	uc001szt.2	+	2	1041	c.609C>G	c.(607-609)GTC>GTG	p.V203V	TMTC2_uc001szr.1_Silent_p.V203V|TMTC2_uc001szs.1_Silent_p.V203V|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	203	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						ATGTCTTTGTCTTTCACAGGC	0.428													G	83251314	G	G	83251314	2	3	238	1	0	0	0	0	0	0	0	1	16258	900	32	5		5	TMTC2	12	83251314	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	6	83251314	50600581	73	16950	21	2									
HVCN1	84329	broad.mit.edu	37	chr12	111089040	111089040	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accattgatgatccgggccaCccgccacagccggagcagaa	11	15	0	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr12:111089040C>A	uc001trs.1	-	6	790	c.625G>T	c.(625-627)GTG>TTG	p.V209L	HVCN1_uc001trq.1_Missense_Mutation_p.V209L|HVCN1_uc001trt.1_Missense_Mutation_p.V209L|HVCN1_uc010syd.1_Missense_Mutation_p.V189L	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	209	Helical; Name=Segment S4; (By similarity).				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						ATCCGGGCCACCCGCCACAGC	0.602													A	111089040	A	A	111089040	3	1	238	1	0	0	0	0	1	0	0	0	7462	507	18	5	208	5	HVCN1	12	111089040	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	27837726	111089040	22762855	74	16951											
TBX5	6910	broad.mit.edu	37	chr12	114832609	114832609	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaagacgtgagtgcagaaCgctgtattttttgagccaaa	12	6	0	4	rs139329918	byFrequency	TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr12:114832609C>T	uc001tvo.2	-	6	1095	c.600G>A	c.(598-600)GCG>GCA	p.A200A	TBX5_uc001tvp.2_Silent_p.A200A|TBX5_uc001tvq.2_Silent_p.A150A|TBX5_uc010syv.1_Silent_p.A200A	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	200	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GAGTGCAGAACGCTGTATTTT	0.433													T	114832609	T	T	114832609	2	4	238	1	0	0	0	0	0	0	0	1	15658	523	19	1		1	TBX5	12	114832609	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	3743569	114832609	19019286	75	16952											
GCN1L1	10985	broad.mit.edu	37	chr12	120596393	120596393	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acactctggcttcagcaggcGcagggtcacgtggctcacca	12	14	4	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr12:120596393G>A	uc001txo.2	-	25	2789	c.2776C>T	c.(2776-2778)CGC>TGC	p.R926C		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	926					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCAGCAGGCGCAGGGTCACG	0.582													A	120596393	A	A	120596393	3	1	238	1	0	0	0	0	1	0	0	0	6299	1087	38	1	5375	1	GCN1L1	12	120596393	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	5763784	120596393	13255502	76	16953											
SYT16	83851	broad.mit.edu	37	chr14	62547880	62547880	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttccgcctgtacgctgcccGgaagatgacccgagagagaa	12	13	0	4			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr14:62547880G>A	uc001xfu.1	+	4	1519	c.1322G>A	c.(1321-1323)CGG>CAG	p.R441Q	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	441	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TACGCTGCCCGGAAGATGACC	0.567													A	62547880	A	A	62547880	3	1	238	1	0	0	0	0	1	0	0	0	15469	1116	39	2	1336	2	SYT16	14	62547880	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08		62547880	44801660	77	16954											
NRXN3	9369	broad.mit.edu	37	chr14	80130234	80130234	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggtacgcttcaccaggaaCggcggcaacgccaccctgca	12	15	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr14:80130234C>T	uc001xun.2	+	14	2930	c.2439C>T	c.(2437-2439)AAC>AAT	p.N813N	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Silent_p.N181N|NRXN3_uc010asw.2_Silent_p.N181N|NRXN3_uc001xur.3_Silent_p.N181N	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1186	Extracellular (Potential).|Laminin G-like 6.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TCACCAGGAACGGCGGCAACG	0.488													T	80130234	T	T	80130234	2	4	238	1	0	0	0	0	0	0	0	1	10667	535	19	1		1	NRXN3	14	80130234	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	17582354	80130234	27219306	78	16955											
JAG2	3714	broad.mit.edu	37	chr14	105609172	105609172	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtgagaggaacttctccgCctccagggagtcctcctcac	11	14	2	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr14:105609172C>T	uc001yqg.2	-	26	3981	c.3577G>A	c.(3577-3579)GCG>ACG	p.A1193T	JAG2_uc010axf.2_Silent_p.R16R|JAG2_uc001yqf.2_Missense_Mutation_p.A597T|JAG2_uc001yqh.2_Missense_Mutation_p.A1155T	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1193	Cytoplasmic (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		AACTTCTCCGCCTCCAGGGAG	0.512													T	105609172	T	T	105609172	3	4	238	1	0	0	0	0	1	0	0	0	7935	739	26	3	143	3	JAG2	14	105609172	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	25478938	105609172	1740368	79	16956											
SLC28A2	9153	broad.mit.edu	37	chr15	45556870	45556870	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taggtgtcctggaggacagtGttttcgggcctaggtcttca	14	8	2	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr15:45556870G>A	uc001zva.2	+	7	671	c.606G>A	c.(604-606)GTG>GTA	p.V202V		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	202	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		GGAGGACAGTGTTTTCGGGCC	0.433													A	45556870	A	A	45556870	2	1	238	1	0	0	0	0	0	0	0	1	14532	1364	48	3		3	SLC28A2	15	45556870	Silent	SNP	G	TCGA-32-4211-01A-01D-1353-08		45556870	56974522	80	16957											
HERC1	8925	broad.mit.edu	37	chr15	63970125	63970125	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcccagcagcgtggcatggCgcccagtttgcttgtgaaca	12	13	0	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr15:63970125C>T	uc002amp.2	-	37	7137	c.6989G>A	c.(6988-6990)CGC>CAC	p.R2330H		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2330					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CGTGGCATGGCGCCCAGTTTG	0.527													T	63970125	T	T	63970125	3	4	238	1	0	0	0	0	1	0	0	0	7057	768	27	1	7764	1	HERC1	15	63970125	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	18413255	63970125	38561267	81	16958											
TLE3	7090	broad.mit.edu	37	chr15	70347545	70347545	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagtgtgttgatctgccggGcgtgcctcgggatgccgggg	19	9	1	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr15:70347545G>A	uc002asm.2	-	15	2549	c.1430C>T	c.(1429-1431)GCC>GTC	p.A477V	TLE3_uc002ask.2_Missense_Mutation_p.A404V|TLE3_uc002asl.2_Missense_Mutation_p.A477V|TLE3_uc010ukd.1_Missense_Mutation_p.A467V|TLE3_uc010bik.1_Missense_Mutation_p.A58V|TLE3_uc010bil.1_Missense_Mutation_p.A474V|TLE3_uc002asn.2_Missense_Mutation_p.A465V|TLE3_uc002asp.2_Missense_Mutation_p.A469V|TLE3_uc002aso.2_Missense_Mutation_p.A472V	NM_005078	NP_005069	Q04726	TLE3_HUMAN	transducin-like enhancer protein 3 isoform a	477					organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2						GATCTGCCGGGCGTGCCTCGG	0.642													A	70347545	A	A	70347545	3	1	238	1	0	0	0	0	1	0	0	0	15937	1203	42	3	912	3	TLE3	15	70347545	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	6377420	70347545	32183847	82	16959											
NOD2	64127	broad.mit.edu	37	chr16	50763750	50763750	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtccaataactgcatcacCtacctaggggcagaagccct	8	13	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr16:50763750C>T	uc002egm.1	+	11	3093	c.2988C>T	c.(2986-2988)ACC>ACT	p.T996T	NOD2_uc010vgq.1_Silent_p.T41T	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	996	LRR 8.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				ACTGCATCACCTACCTAGGGG	0.408													T	50763750	T	T	50763750	2	4	238	1	0	0	0	0	0	0	0	1	10517	668	24	3		3	NOD2	16	50763750	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08		50763750	39591003	83	16960											
KLHL36	79786	broad.mit.edu	37	chr16	84691222	84691222	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cgagggcttcatcgaggaggCcgtgcgctaccacaacaacc	12	14	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr16:84691222C>A	uc002fig.2	+	3	950	c.809C>A	c.(808-810)GCC>GAC	p.A270D	KLHL36_uc010chl.2_Missense_Mutation_p.A269D	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	270										skin(2)	2						ATCGAGGAGGCCGTGCGCTAC	0.677													A	84691222	A	A	84691222	3	1	238	1	0	0	0	0	1	0	0	0	8389	739	26	5	815	5	KLHL36	16	84691222	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	33927472	84691222	5663531	84	16961											
ZC3H18	124245	broad.mit.edu	37	chr16	88643657	88643657	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggatttggacggggcgggGgtgagggcttctgatctgga	20	6	2	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr16:88643657G>A	uc002fky.2	+	2	326	c.126G>A	c.(124-126)GGG>GGA	p.G42G	ZC3H18_uc010voy.1_Silent_p.G42G|ZC3H18_uc010voz.1_Silent_p.G42G|ZC3H18_uc010vpa.1_Silent_p.G42G	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	42						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		ACGGGGCGGGGGTGAGGGCTT	0.612													A	88643657	A	A	88643657	2	1	238	1	0	0	0	0	0	0	0	1	17565	1219	43	3		3	ZC3H18	16	88643657	Silent	SNP	G	TCGA-32-4211-01A-01D-1353-08	3952435	88643657	1711096	85	16962											
NLRP1	22861	broad.mit.edu	37	chr17	5461860	5461860	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagtctcgtacaagcagtggAgggactccagagagtgtggc	16	8	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr17:5461860A>G	uc002gci.2	-	4	2711	c.2156T>C	c.(2155-2157)CTC>CCC	p.L719P	NLRP1_uc002gcg.1_Missense_Mutation_p.L719P|NLRP1_uc002gck.2_Missense_Mutation_p.L719P|NLRP1_uc002gcj.2_Missense_Mutation_p.L719P|NLRP1_uc002gcl.2_Missense_Mutation_p.L719P|NLRP1_uc002gch.3_Missense_Mutation_p.L719P|NLRP1_uc010clh.2_Missense_Mutation_p.L719P	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	719					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				CAAGCAGTGGAGGGACTCCAG	0.537													G	5461860	G	G	5461860	3	3	238	1	0	0	0	0	1	0	0	0	10471	304	11	4	2396	4	NLRP1	17	5461860	Missense_Mutation	SNP	A	TCGA-32-4211-01A-01D-1353-08		5461860	75733350	86	16963											
DNAH2	146754	broad.mit.edu	37	chr17	7643075	7643075	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgactgtcagtatcacttcGcccgctgggaagatggcaag	13	10	2	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr17:7643075G>A	uc002giu.1	+	8	1209	c.1195G>A	c.(1195-1197)GCC>ACC	p.A399T	DNAH2_uc002git.2_Missense_Mutation_p.A481T|DNAH2_uc010vuk.1_Missense_Mutation_p.A399T	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	399	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GTATCACTTCGCCCGCTGGGA	0.488													A	7643075	A	A	7643075	3	1	238	1	0	0	0	0	1	0	0	0	4602	1087	38	1	1225	1	DNAH2	17	7643075	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	2181215	7643075	73552135	87	16964											
TP53I13	90313	broad.mit.edu	37	chr17	27899699	27899699	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggggcccacagcggacagCcaggacacagtggctggtga	17	11	0	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr17:27899699C>T	uc002hee.2	+	6	1091	c.1053C>T	c.(1051-1053)AGC>AGT	p.S351S		NM_138349	NP_612358	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	351	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane					0				READ - Rectum adenocarcinoma(3;0.236)		CAGCGGACAGCCAGGACACAG	0.701													T	27899699	T	T	27899699	2	4	238	1	0	0	0	0	0	0	0	1	16383	738	26	3		3	TP53I13	17	27899699	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	20256624	27899699	53295511	88	16965											
RHBDL3	162494	broad.mit.edu	37	chr17	30611787	30611787	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaggtcctcctggctcttgCcgacagccacgcggatgggc	15	14	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr17:30611787C>T	uc002hhe.1	+	3	259	c.245C>T	c.(244-246)GCC>GTC	p.A82V	RHBDL3_uc010csw.1_Missense_Mutation_p.A74V|RHBDL3_uc010csx.1_Missense_Mutation_p.A82V|RHBDL3_uc010csy.1_Intron|RHBDL3_uc002hhf.1_Intron	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	82	EF-hand 2.				proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				CTGGCTCTTGCCGACAGCCAC	0.592													T	30611787	T	T	30611787	3	4	238	1	0	0	0	0	1	0	0	0	13323	739	26	3	255	3	RHBDL3	17	30611787	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	2712088	30611787	50583423	89	16966											
ZNF207	7756	broad.mit.edu	37	chr17	30685561	30685561	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgccgtaccaaatgcaataCctggaagaacagacatagag	9	9	0	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr17:30685561C>T	uc002hhh.3	+	3	356	c.208C>T	c.(208-210)CCT>TCT	p.P70S	ZNF207_uc002hhj.3_Missense_Mutation_p.P70S|ZNF207_uc002hhi.3_Missense_Mutation_p.P70S|ZNF207_uc010csz.2_Missense_Mutation_p.P73S|ZNF207_uc002hhk.1_Missense_Mutation_p.P70S|ZNF207_uc002hhl.1_5'Flank	NM_003457	NP_003448	O43670	ZN207_HUMAN	zinc finger protein 207 isoform a	70						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			AAATGCAATACCTGGAAGAAC	0.333													T	30685561	T	T	30685561	3	4	238	1	0	0	0	0	1	0	0	0	17762	507	18	3	218	3	ZNF207	17	30685561	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	73774	30685561	50509649	90	16967											
KRT9	3857	broad.mit.edu	37	chr17	39725742	39725742	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagctgctcatactcctgaCgcatgtcattgagggtcttg	11	10	3	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr17:39725742C>T	uc002hxe.3	-	4	1046	c.980G>A	c.(979-981)CGT>CAT	p.R327H	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	327	Rod.|Coil 2.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				ATACTCCTGACGCATGTCATT	0.448													T	39725742	T	T	39725742	3	4	238	1	0	0	0	0	1	0	0	0	8501	536	19	1	907	1	KRT9	17	39725742	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	9040181	39725742	41469468	91	16968											
ACLY	47	broad.mit.edu	37	chr17	40065323	40065323	+	Splice_Site	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gataaaactggccagaattcTagaggtgggagggagagagg	17	4	1	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr17:40065323T>G	uc002hyg.2	-	6	700	c.537_splice	c.e6-1	p.E179_splice	ACLY_uc002hyh.2_Splice_Site_p.E179_splice|ACLY_uc002hyi.2_Splice_Site_p.E233_splice|ACLY_uc010wfx.1_Splice_Site_p.E233_splice|ACLY_uc010wfy.1_Intron	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1						ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				GCCAGAATTCTAGAGGTGGGA	0.562													G	40065323	G	G	40065323	5	3	238	1	0	0	0	0	0	0	1	0	143	1536	53	5	2866	5	ACLY	17	40065323	Splice_Site	SNP	T	TCGA-32-4211-01A-01D-1353-08	339581	40065323	41129887	92	16969											
SMCHD1	23347	broad.mit.edu	37	chr18	2752502	2752502	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaggcagaaacatttagttGtaataaaataaaagataatg	7	3	0	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr18:2752502G>A	uc002klm.3	+	34	4487	c.4298G>A	c.(4297-4299)TGT>TAT	p.C1433Y	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1433					chromosome organization		ATP binding				0						ACATTTAGTTGTAATAAAATA	0.303													A	2752502	A	A	2752502	3	1	238	1	0	0	0	0	1	0	0	0	14788	1377	48	3	4432	3	SMCHD1	18	2752502	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08		2752502	75324746	93	16970											
LAMA1	284217	broad.mit.edu	37	chr18	7036079	7036079	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatttcaggaatccgccaaaCgcagtcagctgaaatgttta	8	9	2	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr18:7036079C>T	uc002knm.2	-	13	1840	c.1746G>A	c.(1744-1746)GCG>GCA	p.A582A	LAMA1_uc010wzj.1_Silent_p.A58A	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	582	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATCCGCCAAACGCAGTCAGCT	0.463													T	7036079	T	T	7036079	2	4	238	1	0	0	0	0	0	0	0	1	8605	523	19	1		1	LAMA1	18	7036079	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	4283577	7036079	71041169	94	16971											
PTBP1	5725	broad.mit.edu	37	chr19	804908	804908	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggccctgctgcagtatgCggaccccgtgagcgcccagc	13	17	0	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr19:804908C>T	uc002lpr.2	+	7	792	c.686C>T	c.(685-687)GCG>GTG	p.A229V	PTBP1_uc002lpp.2_Missense_Mutation_p.A229V|PTBP1_uc002lpq.2_Missense_Mutation_p.A229V|PTBP1_uc002lps.2_Intron|PTBP1_uc002lpt.2_RNA|PTBP1_uc002lpu.1_Missense_Mutation_p.A199V	NM_031991	NP_114368	P26599	PTBP1_HUMAN	polypyrimidine tract-binding protein 1 isoform	229	RRM 2.				negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			kidney(1)|skin(1)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCAGTATGCGGACCCCGTG	0.662													T	804908	T	T	804908	3	4	238	1	0	0	0	0	1	0	0	0	12725	768	27	1	712	1	PTBP1	19	804908	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08		804908	58324075	95	16972											
SBNO2	22904	broad.mit.edu	37	chr19	1119057	1119057	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgaaggctggggccagcgGgatctcctcgatgcggaagg	17	11	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr19:1119057G>A	uc002lrk.3	-	14	1718	c.1480C>T	c.(1480-1482)CCG>TCG	p.P494S	SBNO2_uc002lrj.3_Missense_Mutation_p.P437S|SBNO2_uc010dse.2_Missense_Mutation_p.P487S|SBNO2_uc010xgj.1_Intron|SBNO2_uc010dsf.2_Missense_Mutation_p.P437S	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	494					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGCCAGCGGGATCTCCTCG	0.657													A	1119057	A	A	1119057	3	1	238	1	0	0	0	0	1	0	0	0	13863	1232	43	3	2696	3	SBNO2	19	1119057	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	314149	1119057	58009926	96	16973											
TLE2	7089	broad.mit.edu	37	chr19	3013710	3013710	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gcagcggtgagccaaggctaGaggccaaggaggctggactg	18	9	0	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr19:3013710G>A	uc002lww.2	-	11	1093	c.830C>T	c.(829-831)TCT>TTT	p.S277F	TLE2_uc010xhb.1_5'UTR|TLE2_uc010dth.2_Missense_Mutation_p.S278F|TLE2_uc010xhc.1_Missense_Mutation_p.S155F|TLE2_uc010dti.2_Missense_Mutation_p.S291F|TLE2_uc010xhd.1_Missense_Mutation_p.S185F	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	277	Pro/Ser-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAAGGCTAGAGGCCAAGGA	0.642													A	3013710	A	A	3013710	3	1	238	1	0	0	0	0	1	0	0	0	15936	942	33	3	1441	3	TLE2	19	3013710	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	1894653	3013710	56115273	97	16974											
MUC16	94025	broad.mit.edu	37	chr19	8997446	8997446	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccctctccgtggtgttgaacTtcctggagccagggtgctgc	13	13	1	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr19:8997446T>G	uc002mkp.2	-	59	41180	c.40976A>C	c.(40975-40977)AAG>ACG	p.K13659T	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.K476T|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13661	Extracellular (Potential).|SEA 11.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGTTGAACTTCCTGGAGCC	0.567													G	8997446	G	G	8997446	3	3	238	1	0	0	0	0	1	0	0	0	9973	1609	56	5	2651	5	MUC16	19	8997446	Missense_Mutation	SNP	T	TCGA-32-4211-01A-01D-1353-08	5983736	8997446	50131537	98	16975											
ZNF527	84503	broad.mit.edu	37	chr19	37880558	37880558	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaatgtggaaaggccttcaGttgtggctcatatcttaatc	9	8	3	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr19:37880558G>A	uc010efk.1	+	5	1718	c.1607G>A	c.(1606-1608)AGT>AAT	p.S536N	ZNF527_uc002ogf.3_Missense_Mutation_p.S504N|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	536	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAGGCCTTCAGTTGTGGCTCA	0.398													A	37880558	A	A	37880558	3	1	238	1	0	0	0	0	1	0	0	0	17965	1029	36	3	1621	3	ZNF527	19	37880558	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	28883112	37880558	21248425	99	16976											
ZNF229	7772	broad.mit.edu	37	chr19	44933459	44933459	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcttgaaggtacgagttgtgActgaaacctttgccacactt	10	9	0	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr19:44933459A>G	uc002oze.1	-	6	1931	c.1497T>C	c.(1495-1497)AGT>AGC	p.S499S	ZNF229_uc010ejk.1_Silent_p.S153S|ZNF229_uc010ejl.1_Silent_p.S493S	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	499	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				ACGAGTTGTGACTGAAACCTT	0.517													G	44933459	G	G	44933459	2	3	238	1	0	0	0	0	0	0	0	1	17779	272	10	4		4	ZNF229	19	44933459	Silent	SNP	A	TCGA-32-4211-01A-01D-1353-08	7052901	44933459	14195524	100	16977											
ZNF816A	125893	broad.mit.edu	37	chr19	53454033	53454033	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctctccagtatgaagtctaCgatggcatctaagggatgac	10	9	3	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr19:53454033C>T	uc002qal.1	-	5	1296	c.995G>A	c.(994-996)CGT>CAT	p.R332H	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.R316H	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	332	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		ATGAAGTCTACGATGGCATCT	0.423													T	53454033	T	T	53454033	3	4	238	1	0	0	0	0	1	0	0	0	18174	536	19	1	964	1	ZNF816A	19	53454033	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	8520574	53454033	5674950	101	16978											
PRIC285	85441	broad.mit.edu	37	chr20	62198405	62198405	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggggtggggcggaaccttgCccctggcgtggatggggttg	22	8	0	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr20:62198405C>T	uc002yfm.2	-	7	3198	c.2306G>A	c.(2305-2307)GGC>GAC	p.G769D	PRIC285_uc002yfl.1_Missense_Mutation_p.G200D	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	769					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CGGAACCTTGCCCCTGGCGTG	0.652													T	62198405	T	T	62198405	3	4	238	1	0	0	0	0	1	0	0	0	12485	739	26	3	5699	3	PRIC285	20	62198405	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08		62198405	827115	102	16979											
KRTAP20-2	337976	broad.mit.edu	37	chr21	32007617	32007617	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caactactatggtggtctgcGttatggctatggagtcctgg	13	8	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr21:32007617G>A	uc011adg.1	+	1	35	c.35G>A	c.(34-36)CGT>CAT	p.R12H		NM_181616	NP_853647	Q3LI61	KR202_HUMAN	keratin associated protein 20-2	12						intermediate filament				central_nervous_system(1)	1						GGTGGTCTGCGTTATGGCTAT	0.522													A	32007617	A	A	32007617	3	1	238	1	0	0	0	0	1	0	0	0	8537	1145	40	1	37	1	KRTAP20-2	21	32007617	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08		32007617	16122278	103	16980											
ICOSLG	23308	broad.mit.edu	37	chr21	45657002	45657002	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcactggtttgccaatataCgtaaacatcatttaaatcaa	4	9	3	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr21:45657002C>T	uc002zee.2	-	3	288	c.154G>A	c.(154-156)GTA>ATA	p.V52I	ICOSLG_uc011afc.1_Intron|ICOSLG_uc002zef.2_Intron|ICOSLG_uc010gpp.1_Missense_Mutation_p.V52I	NM_015259	NP_056074	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand precursor	52	Ig-like V-type.|Extracellular (Potential).				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding				0				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		TGCCAATATACGTAAACATCA	0.522													T	45657002	T	T	45657002	3	4	238	1	0	0	0	0	1	0	0	0	7487	536	19	1	774	1	ICOSLG	21	45657002	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08	13649385	45657002	2472893	104	16981											
C21orf29	54084	broad.mit.edu	37	chr21	45945664	45945664	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttctgtggctccatttgtaaAtgacagagaactcctgaccc	8	11	1	3			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr21:45945664A>G	uc002zfe.1	-	8	1274	c.1208T>C	c.(1207-1209)ATT>ACT	p.I403T	C21orf29_uc010gpv.1_Missense_Mutation_p.I335T	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	403	EAR 2.				cell adhesion	extracellular region	structural molecule activity				0						CCATTTGTAAATGACAGAGAA	0.522													G	45945664	G	G	45945664	3	3	238	1	0	0	0	0	1	0	0	0	2124	101	4	4	821	4	C21orf29	21	45945664	Missense_Mutation	SNP	A	TCGA-32-4211-01A-01D-1353-08	288662	45945664	2184231	105	16982											
PCBP3	54039	broad.mit.edu	37	chr21	47355174	47355174	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggtatacccaggtctggaCgccagcccaccggccagcac	11	16	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr21:47355174C>T	uc002zhq.1	+	12	989	c.864C>T	c.(862-864)GAC>GAT	p.D288D	PCBP3_uc010gqb.2_Silent_p.D288D|PCBP3_uc002zhp.1_Silent_p.D268D|PCBP3_uc002zhs.1_Silent_p.D262D|PCBP3_uc002zhr.1_Silent_p.D287D|PCBP3_uc002zht.1_Silent_p.D278D	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	288					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		CAGGTCTGGACGCCAGCCCAC	0.577													T	47355174	T	T	47355174	2	4	238	1	0	0	0	0	0	0	0	1	11502	535	19	1		1	PCBP3	21	47355174	Silent	SNP	C	TCGA-32-4211-01A-01D-1353-08	1409510	47355174	774721	106	16983											
RFPL2	10739	broad.mit.edu	37	chr22	32586778	32586778	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttatttggcctccccaggaCggactggagcatcagtagtg	12	11	1	0			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr22:32586778C>T	uc003amg.3	-	5	2054	c.1118G>A	c.(1117-1119)CGT>CAT	p.R373H	RFPL2_uc003ame.3_Missense_Mutation_p.R312H|RFPL2_uc003amf.3_Missense_Mutation_p.R283H|RFPL2_uc003amh.3_Missense_Mutation_p.R283H	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	373							zinc ion binding			skin(1)	1						CTCCCCAGGACGGACTGGAGC	0.463													T	32586778	T	T	32586778	3	4	238	1	0	0	0	0	1	0	0	0	13254	536	19	1	22	1	RFPL2	22	32586778	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08		32586778	18717788	107	16984											
RFPL3	10738	broad.mit.edu	37	chr22	32756800	32756800	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactactgatgctccagtccGtcctggggaggccaaataag	11	12	0	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chr22:32756800G>A	uc003amj.2	+	2	1140	c.935G>A	c.(934-936)CGT>CAT	p.R312H	RFPL3_uc010gwn.2_Missense_Mutation_p.R283H|RFPL3S_uc003amk.2_RNA|RFPL3S_uc003aml.2_RNA	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	312							zinc ion binding			ovary(1)	1						GCTCCAGTCCGTCCTGGGGAG	0.458													A	32756800	A	A	32756800	3	1	238	1	0	0	0	0	1	0	0	0	13255	1145	40	1	941	1	RFPL3	22	32756800	Missense_Mutation	SNP	G	TCGA-32-4211-01A-01D-1353-08	170022	32756800	18547766	108	16985											
WNK3	65267	broad.mit.edu	37	chrX	54275317	54275317	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctatgacttctgtcactggaCaggagagggtatcttcagca	11	9	4	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chrX:54275317C>A	uc004dtd.1	-	17	3903	c.3464G>T	c.(3463-3465)TGT>TTT	p.C1155F	WNK3_uc004dtc.1_Missense_Mutation_p.C1155F	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1155					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TGTCACTGGACAGGAGAGGGT	0.458													A	54275317	A	A	54275317	3	1	238	1	0	0	0	0	1	0	0	0	17376	478	17	5	1970	5	WNK3	23	54275317	Missense_Mutation	SNP	C	TCGA-32-4211-01A-01D-1353-08		54275317	100995243	109	16986											
SPIN3	169981	broad.mit.edu	37	chrX	57021377	57021377	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcctttccaaacggggtctTcatgcctgcgaagaggagca	12	11	2	1			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chrX:57021377T>G	uc010nkj.2	-	2	290	c.4A>C	c.(4-6)AAG>CAG	p.K2Q	SPIN3_uc004duu.3_RNA|SPIN3_uc004duw.3_RNA|SPIN3_uc004duv.3_RNA|SPIN3_uc004dux.1_Missense_Mutation_p.K2Q	NM_001010862	NP_001010862	Q5JUX0	SPIN3_HUMAN	spindlin family, member 3	2					gamete generation					ovary(1)|central_nervous_system(1)	2						AACGGGGTCTTCATGCCTGCG	0.537													G	57021377	G	G	57021377	3	3	238	1	0	0	0	0	1	0	0	0	15054	1792	62	5	776	5	SPIN3	23	57021377	Missense_Mutation	SNP	T	TCGA-32-4211-01A-01D-1353-08	2746060	57021377	98249183	110	16987											
TAF1	6872	broad.mit.edu	37	chrX	70680548	70680548	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagacccaaacaaccccgcaTgcttcaggagaacacaagga	8	13	1	2			TCGA-32-4211-01A-01D-1353-08	TCGA-32-4211-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	08014470-8cdc-4431-baee-a06009d4cf3a	939f2072-4045-46d3-a164-a6ea49da87b7	g.chrX:70680548T>G	uc004dzu.3	+	37	5342	c.5291T>G	c.(5290-5292)ATG>AGG	p.M1764R	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.M1785R|TAF1_uc004dzv.3_Missense_Mutation_p.M972R|TAF1_uc010nle.1_RNA|TAF1_uc010nlf.1_Missense_Mutation_p.M189R|TAF1_uc004dzx.2_RNA|TAF1_uc004dzy.2_RNA|TAF1_uc004dzw.1_RNA|TAF1_uc010nlg.1_RNA	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1764	Asp/Glu-rich (acidic tail).|Protein kinase 2.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				CAACCCCGCATGCTTCAGGAG	0.483													G	70680548	G	G	70680548	3	3	238	1	0	0	0	0	1	0	0	0	15510	1464	51	5	5500	5	TAF1	23	70680548	Missense_Mutation	SNP	T	TCGA-32-4211-01A-01D-1353-08	13659171	70680548	84590012	111	16988											
CHD5	26038	broad.mit.edu	37	chr1	6171855	6171855	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcacgatgcccgccagcagCcagtagtcatggcgccggtg	14	14	2	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr1:6171855C>T	uc001amb.1	-	36	5329	c.5229G>A	c.(5227-5229)TGG>TGA	p.W1743*	CHD5_uc001alz.1_Nonsense_Mutation_p.W600*|CHD5_uc001ama.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1743					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCGCCAGCAGCCAGTAGTCAT	0.577													T	6171855	T	T	6171855	4	4	239	1	0	0	0	0	0	1	0	0	3328	740	26	3	659	3	CHD5	1	6171855	Nonsense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08		6171855	243078766	1	16989											
CDA	978	broad.mit.edu	37	chr1	20944973	20944973	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caactggcccgtgtacatgaCcaagccggatggtacgtata	11	11	0	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr1:20944973C>T	uc001bdk.2	+	4	532	c.353C>T	c.(352-354)ACC>ATC	p.T118I	CDA_uc001bdl.2_RNA|CDA_uc009vpv.2_RNA	NM_001785	NP_001776	P32320	CDD_HUMAN	cytidine deaminase	118					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	GTGTACATGACCAAGCCGGAT	0.378													T	20944973	T	T	20944973	3	4	239	1	0	0	0	0	1	0	0	0	3052	507	18	3	367	3	CDA	1	20944973	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	14773118	20944973	228305648	2	16990											
HNRNPR	10236	broad.mit.edu	37	chr1	23660032	23660032	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgttccaattccaggttgCacgccagagtacacactgtc	8	14	0	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr1:23660032C>T	uc001bgr.3	-	5	636	c.477G>A	c.(475-477)GTG>GTA	p.V159V	HNRNPR_uc001bgp.3_Silent_p.V159V|HNRNPR_uc009vqk.2_Silent_p.V58V|HNRNPR_uc001bgs.3_Silent_p.V58V|HNRNPR_uc010odw.1_Intron|HNRNPR_uc010odx.1_Silent_p.V58V|HNRNPR_uc009vql.2_Intron	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	159						catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		TTCCAGGTTGCACGCCAGAGT	0.453													T	23660032	T	T	23660032	2	4	239	1	0	0	0	0	0	0	0	1	7272	697	25	3		3	HNRNPR	1	23660032	Silent	SNP	C	TCGA-32-4213-01A-01D-1353-08	2715059	23660032	225590589	3	16991											
TXNIP	10628	broad.mit.edu	37	chr1	145439907	145439907	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtagtggatctggtggatgtCaatacccctgatttaatggt	12	6	2	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr1:145439907C>T	uc001enn.3	+	3	794	c.453C>T	c.(451-453)GTC>GTT	p.V151V	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Silent_p.V96V	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	151					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGGTGGATGTCAATACCCCTG	0.433													T	145439907	T	T	145439907	2	4	239	1	0	0	0	0	0	0	0	1	16800	813	29	3		3	TXNIP	1	145439907	Silent	SNP	C	TCGA-32-4213-01A-01D-1353-08	121779875	145439907	103810714	4	16992											
RXFP4	339403	broad.mit.edu	37	chr1	155911855	155911855	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccctctgcaagatggttctgAcggccactgtcctcaacgtc	9	15	3	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr1:155911855A>C	uc010pgs.1	+	1	376	c.355A>C	c.(355-357)ACG>CCG	p.T119P		NM_181885	NP_871001	Q8TDU9	RL3R2_HUMAN	relaxin 3 receptor 2	119	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	angiotensin type II receptor activity				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GATGGTTCTGACGGCCACTGT	0.632													C	155911855	C	C	155911855	3	2	239	1	0	0	0	0	1	0	0	0	13762	275	10	5	357	5	RXFP4	1	155911855	Missense_Mutation	SNP	A	TCGA-32-4213-01A-01D-1353-08	10471948	155911855	93338766	5	16993											
NME7	29922	broad.mit.edu	37	chr1	169256604	169256604	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtaaatttagcagtgtttgCcggcccacaacctccacttg	8	12	0	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr1:169256604C>T	uc001gfu.2	-	7	929	c.691G>A	c.(691-693)GCA>ACA	p.A231T	NME7_uc010plq.1_RNA|NME7_uc001gft.2_Missense_Mutation_p.A195T|NME7_uc001gfv.1_Missense_Mutation_p.A231T	NM_013330	NP_037462	Q9Y5B8	NDK7_HUMAN	nucleoside diphosphate kinase 7 isoform a	231					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)					GCAGTGTTTGCCGGCCCACAA	0.358													T	169256604	T	T	169256604	3	4	239	1	0	0	0	0	1	0	0	0	10496	739	26	3	463	3	NME7	1	169256604	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	13344749	169256604	79994017	6	16994											
IGFN1	91156	broad.mit.edu	37	chr1	201182608	201182608	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctgaatgaagatcagagcCgggagccccctggtcacctt	12	12	2	4			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr1:201182608C>T	uc001gwc.2	+	1	839	c.67C>T	c.(67-69)CGG>TGG	p.R23W	IGFN1_uc001gwb.2_Intron	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						AGATCAGAGCCGGGAGCCCCC	0.582													T	201182608	T	T	201182608	3	4	239	1	0	0	0	0	1	0	0	0	7590	643	23	2	8629	2	IGFN1	1	201182608	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	31926004	201182608	48068013	7	16995											
KDM5B	10765	broad.mit.edu	37	chr1	202722182	202722182	+	Frame_Shift_Del	DEL	T	-	-													ccctgggactccataccaggTttttggctcacccctggaaa							TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr1:202722182delT	uc001gyf.2	-	12	1668	c.1552delA	c.(1552-1554)ACCfs	p.T518fs	KDM5B_uc009xag.2_Frame_Shift_Del_p.T554fs|KDM5B_uc001gyg.1_Frame_Shift_Del_p.T360fs	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	518	JmjC.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						CCATACCAGGTTTTTGGCTCA	0.423													-	202722182	-	-	202722182	7	5	239	1	0	1	0	1	0	0	0	0	8134	1725	60	0	3146	0	KDM5B	1	202722182	Frame_Shift_Del	DEL	T	TCGA-32-4213-01A-01D-1353-08	1539574	202722182	46528439	8	16996											
TIA1	7072	broad.mit.edu	37	chr2	70457951	70457951	+	Frame_Shift_Del	DEL	A	-	-													gctgcatgacgatgctcatgAaactccacaaaacaataggg							TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr2:70457951delA	uc002sgj.3	-	3	376	c.159delT	c.(157-159)TTTfs	p.F53fs	TIA1_uc002sgk.3_Frame_Shift_Del_p.F53fs|TIA1_uc002sgl.3_RNA|TIA1_uc002sgm.3_Frame_Shift_Del_p.F53fs|TIA1_uc010yqt.1_Frame_Shift_Del_p.F53fs	NM_022173	NP_071505	P31483	TIA1_HUMAN	TIA1 cytotoxic granule-associated RNA binding	53	RRM 1.				apoptosis|induction of apoptosis|regulation of nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|poly(A) RNA binding|protein binding				0						GATGCTCATGAAACTCCACAA	0.398													-	70457951	-	-	70457951	7	5	239	1	0	1	0	1	0	0	0	0	15884	243	9	0	1045	0	TIA1	2	70457951	Frame_Shift_Del	DEL	A	TCGA-32-4213-01A-01D-1353-08		70457951	172741422	9	16997											
YSK4	80122	broad.mit.edu	37	chr2	135738775	135738775	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgcgatgtaccacacagttcTcatggagataagcaacacct	8	12	1	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr2:135738775T>C	uc002tue.1	-	9	3567	c.3536A>G	c.(3535-3537)GAG>GGG	p.E1179G	YSK4_uc002tuf.1_Missense_Mutation_p.E361G|YSK4_uc010fnc.1_Missense_Mutation_p.E313G|YSK4_uc010fnd.1_Missense_Mutation_p.E1066G|YSK4_uc010zbg.1_Missense_Mutation_p.E311G|YSK4_uc002tuh.3_Missense_Mutation_p.E907G|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1179	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CACACAGTTCTCATGGAGATA	0.413													C	135738775	C	C	135738775	3	2	239	1	0	0	0	0	1	0	0	0	17492	1551	54	4	458	4	YSK4	2	135738775	Missense_Mutation	SNP	T	TCGA-32-4213-01A-01D-1353-08	65280824	135738775	107460598	10	16998											
TTN	7273	broad.mit.edu	37	chr2	179413171	179413171	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgataacctgccaactaCggcgacttgcctctcgtttc	7	15	1	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr2:179413171C>T	uc010zfg.1	-	288	85702	c.85478G>A	c.(85477-85479)CGT>CAT	p.R28493H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R22188H|TTN_uc010zfi.1_Missense_Mutation_p.R22121H|TTN_uc010zfj.1_Missense_Mutation_p.R21996H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29420							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCCAACTACGGCGACTTGC	0.498													T	179413171	T	T	179413171	3	4	239	1	0	0	0	0	1	0	0	0	16732	536	19	1	14893	1	TTN	2	179413171	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	43674396	179413171	63786202	11	16999											
SPAG16	79582	broad.mit.edu	37	chr2	214204919	214204919	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agatttgctgaaaattcagaAagaacgtgattttcatcgaa	8	5	2	5			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr2:214204919A>G	uc002veq.2	+	6	661	c.569A>G	c.(568-570)AAA>AGA	p.K190R	SPAG16_uc010fuz.1_Missense_Mutation_p.K41R|SPAG16_uc002ver.2_Missense_Mutation_p.K136R|SPAG16_uc010zjk.1_Missense_Mutation_p.K96R|SPAG16_uc002vep.1_Intron|SPAG16_uc002ves.1_Missense_Mutation_p.K159R	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	190	Potential.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AAAATTCAGAAAGAACGTGAT	0.294													G	214204919	G	G	214204919	3	3	239	1	0	0	0	0	1	0	0	0	14978	14	1	4	607	4	SPAG16	2	214204919	Missense_Mutation	SNP	A	TCGA-32-4213-01A-01D-1353-08	34791748	214204919	28994454	12	17000											
FN1	2335	broad.mit.edu	37	chr2	216300455	216300455	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttgctcttcgaggctcccGtggagggcaccgctgtcccc	12	16	2	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr2:216300455G>A	uc002vfa.2	-	1	337	c.71C>T	c.(70-72)ACG>ATG	p.T24M	FN1_uc002vfb.2_Missense_Mutation_p.T24M|FN1_uc002vfc.2_Missense_Mutation_p.T24M|FN1_uc002vfd.2_Missense_Mutation_p.T24M|FN1_uc002vfe.2_Missense_Mutation_p.T24M|FN1_uc002vff.2_Missense_Mutation_p.T24M|FN1_uc002vfg.2_Missense_Mutation_p.T24M|FN1_uc002vfh.2_Missense_Mutation_p.T24M|FN1_uc002vfi.2_Missense_Mutation_p.T24M|FN1_uc002vfj.2_Missense_Mutation_p.T24M|FN1_uc002vfl.2_Missense_Mutation_p.T24M	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	24					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGAGGCTCCCGTGGAGGGCAC	0.667													A	216300455	A	A	216300455	3	1	239	1	0	0	0	0	1	0	0	0	5962	1145	40	1	7579	1	FN1	2	216300455	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	2095536	216300455	26898918	13	17001											
FAM134A	79137	broad.mit.edu	37	chr2	220046155	220046155	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagagacagagagtgaaagCgaggcagagctggctggctt	17	7	0	4			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr2:220046155C>T	uc002vjw.3	+	7	985	c.849C>T	c.(847-849)AGC>AGT	p.S283S	FAM134A_uc010fwc.2_Silent_p.S76S|FAM134A_uc002vjx.2_Silent_p.S76S	NM_024293	NP_077269	Q8NC44	F134A_HUMAN	hypothetical protein LOC79137	283						endoplasmic reticulum|integral to membrane				ovary(1)|central_nervous_system(1)	2		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGAGTGAAAGCGAGGCAGAGC	0.542													T	220046155	T	T	220046155	2	4	239	1	0	0	0	0	0	0	0	1	5445	767	27	1		1	FAM134A	2	220046155	Silent	SNP	C	TCGA-32-4213-01A-01D-1353-08	3745700	220046155	23153218	14	17002											
SP100	6672	broad.mit.edu	37	chr2	231406616	231406616	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttactcaacagaacagagagGggtctcagggcccacagaag	12	10	2	3			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr2:231406616G>A	uc002vqu.1	+	28	2554	c.2413G>A	c.(2413-2415)GGG>AGG	p.G805R	SP100_uc010fxp.1_Missense_Mutation_p.G123R	NM_001080391	NP_001073860	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 1	Error:Variant_position_missing_in_P23497_after_alignment					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GAACAGAGAGGGGTCTCAGGG	0.403													A	231406616	A	A	231406616	3	1	239	1	0	0	0	0	1	0	0	0	14960	1232	43	3	3073	3	SP100	2	231406616	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	11360461	231406616	11792757	15	17003											
HDAC4	9759	broad.mit.edu	37	chr2	240002804	240002804	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggctcacctgaaggccgccaAgtactcagcgtctcccatgg	11	15	3	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr2:240002804A>G	uc002vyk.3	-	22	3514	c.2722T>C	c.(2722-2724)TTG>CTG	p.L908L	HDAC4_uc010fyy.2_Silent_p.L865L	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	908	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AAGGCCGCCAAGTACTCAGCG	0.602													G	240002804	G	G	240002804	2	3	239	1	0	0	0	0	0	0	0	1	7009	69	3	4		4	HDAC4	2	240002804	Silent	SNP	A	TCGA-32-4213-01A-01D-1353-08	8596188	240002804	3196569	16	17004											
CHRD	8646	broad.mit.edu	37	chr3	184099068	184099068	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccctggcagggtcagctgcAagaacatcaaaccagagtgc	12	12	2	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr3:184099068A>G	uc003fov.2	+	3	544	c.298A>G	c.(298-300)AAG>GAG	p.K100E	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Missense_Mutation_p.K100E|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'Flank	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	100	VWFC 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGTCAGCTGCAAGAACATCAA	0.647													G	184099068	G	G	184099068	3	3	239	1	0	0	0	0	1	0	0	0	3372	131	5	4	308	4	CHRD	3	184099068	Missense_Mutation	SNP	A	TCGA-32-4213-01A-01D-1353-08		184099068	13923362	17	17005											
RASSF6	166824	broad.mit.edu	37	chr4	74464408	74464408	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttctcataaaaaatgttataGgtcttcaataaagaattaag	5	4	3	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr4:74464408G>T	uc003hhd.1	-	3	312	c.189C>A	c.(187-189)ACC>ACA	p.T63T	RASSF6_uc003hhc.1_Silent_p.T31T|RASSF6_uc010iik.1_Silent_p.T31T|RASSF6_uc010iil.1_Intron	NM_201431	NP_958834	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family 6	63					apoptosis|signal transduction		protein binding			pancreas(2)	2	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			AAATGTTATAGGTCTTCAATA	0.269													T	74464408	T	T	74464408	2	4	239	1	0	0	0	0	0	0	0	1	13090	987	35	5		5	RASSF6	4	74464408	Silent	SNP	G	TCGA-32-4213-01A-01D-1353-08		74464408	116689868	18	17006											
EGF	1950	broad.mit.edu	37	chr4	110882086	110882086	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gtgtaaaaacacccctggatCctattactgcacgtgccctg	8	13	0	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr4:110882086C>A	uc003hzy.3	+	7	1582	c.1130C>A	c.(1129-1131)TCC>TAC	p.S377Y	EGF_uc011cfu.1_Missense_Mutation_p.S335Y|EGF_uc011cfv.1_Missense_Mutation_p.S377Y	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	377	EGF-like 2; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ACCCCTGGATCCTATTACTGC	0.398													A	110882086	A	A	110882086	3	1	239	1	0	0	0	0	1	0	0	0	4962	855	30	5	1156	5	EGF	4	110882086	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	36417678	110882086	80272190	19	17007											
DNAH5	1767	broad.mit.edu	37	chr5	13883072	13883072	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agggacactgatgatgcactCcacggctttgttcagggtct	12	10	2	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr5:13883072C>A	uc003jfd.2	-	20	3157	c.3115G>T	c.(3115-3117)GAG>TAG	p.E1039*		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1039	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATGATGCACTCCACGGCTTTG	0.537									Kartagener_syndrome				A	13883072	A	A	13883072	4	1	239	1	0	0	0	0	0	1	0	0	4604	864	30	5	10999	5	DNAH5	5	13883072	Nonsense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08		13883072	167032188	20	17008											
AP3B1	8546	broad.mit.edu	37	chr5	77473219	77473219	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attatgccagcttcagatttTggtgatatgtgccaatacag	9	7	1	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr5:77473219T>G	uc003kfj.2	-	9	1109	c.984A>C	c.(982-984)CCA>CCC	p.P328P		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	328					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		CTTCAGATTTTGGTGATATGT	0.348									Hermansky-Pudlak_syndrome				G	77473219	G	G	77473219	2	3	239	1	0	0	0	0	0	0	0	1	744	1799	63	5		5	AP3B1	5	77473219	Silent	SNP	T	TCGA-32-4213-01A-01D-1353-08	63590147	77473219	103442041	21	17009											
GABRG2	2566	broad.mit.edu	37	chr5	161524689	161524689	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcaaacgtggtatgacagaCgtttgaaatttaacagcacc	9	9	0	3			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr5:161524689C>T	uc003lyz.3	+	4	731	c.373C>T	c.(373-375)CGT>TGT	p.R125C	GABRG2_uc010jjc.2_Missense_Mutation_p.R125C|GABRG2_uc003lyy.3_Missense_Mutation_p.R125C|GABRG2_uc011dej.1_Missense_Mutation_p.R30C	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	125	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GTATGACAGACGTTTGAAATT	0.328													T	161524689	T	T	161524689	3	4	239	1	0	0	0	0	1	0	0	0	6172	536	19	1	387	1	GABRG2	5	161524689	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	84051470	161524689	19390571	22	17010											
HLA-DRA	3122	broad.mit.edu	37	chr6	32410459	32410459	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagcgctccaactatactcCgatcaccaatggtacctccc	5	16	1	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr6:32410459C>T	uc003obh.2	+	2	398	c.317C>T	c.(316-318)CCG>CTG	p.P106L	HLA-DRA_uc003obi.2_Missense_Mutation_p.P106L	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	106	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2						AACTATACTCCGATCACCAAT	0.463									T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Kaposi_Sarcoma_Familial_Clustering_of				T	32410459	T	T	32410459	3	4	239	1	0	0	0	0	1	0	0	0	7207	652	23	2	323	2	HLA-DRA	6	32410459	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08		32410459	138704608	23	17011											
DNAH8	1769	broad.mit.edu	37	chr6	38773311	38773311	+	Frame_Shift_Del	DEL	A	-	-													aggagagggtgaaaacaatgActatgaagctaatattgtga							TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr6:38773311delA	uc003ooe.1	+	21	3038	c.2438delA	c.(2437-2439)GACfs	p.D813fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GAAAACAATGACTATGAAGCT	0.308													-	38773311	-	-	38773311	7	5	239	1	0	1	0	1	0	0	0	0	4607	275	10	0	2512	0	DNAH8	6	38773311	Frame_Shift_Del	DEL	A	TCGA-32-4213-01A-01D-1353-08	6362852	38773311	132341756	24	17012											
HEY2	23493	broad.mit.edu	37	chr6	126080811	126080811	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccccatgcttcccccaaacGcagcagcagcagtggccgcg	10	18	0	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr6:126080811G>A	uc003qad.2	+	5	1068	c.877G>A	c.(877-879)GCA>ACA	p.A293T	HEY2_uc011ebr.1_Missense_Mutation_p.A247T	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	293	Ala-rich.				negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		TCCCCCAAACGCAGCAGCAGC	0.647													A	126080811	A	A	126080811	3	1	239	1	0	0	0	0	1	0	0	0	7079	1087	38	1	895	1	HEY2	6	126080811	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	87307500	126080811	45034256	25	17013											
USP42	84132	broad.mit.edu	37	chr7	6189851	6189851	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgaaagaaaacggcctagCgcctgatggtgccagctgcc	12	14	0	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr7:6189851C>T	uc011jwo.1	+	13	2147	c.2024C>T	c.(2023-2025)GCG>GTG	p.A675V	USP42_uc010kth.1_Missense_Mutation_p.A608V|USP42_uc011jwp.1_Missense_Mutation_p.A675V|USP42_uc011jwq.1_Missense_Mutation_p.A482V|USP42_uc011jwr.1_Missense_Mutation_p.A520V	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	675					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		AACGGCCTAGCGCCTGATGGT	0.562													T	6189851	T	T	6189851	3	4	239	1	0	0	0	0	1	0	0	0	17070	768	27	1	2070	1	USP42	7	6189851	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08		6189851	152948812	26	17014											
ZNF479	90827	broad.mit.edu	37	chr7	57194352	57194352	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacatctctatataaattcCgctgagcacaatccaggcat	5	12	2	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr7:57194352C>T	uc010kzo.2	-	3	384	c.113G>A	c.(112-114)CGG>CAG	p.R38Q		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	38	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ATATAAATTCCGCTGAGCACA	0.398													T	57194352	T	T	57194352	3	4	239	1	0	0	0	0	1	0	0	0	17930	652	23	2	1473	2	ZNF479	7	57194352	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	51004501	57194352	101944311	27	17015											
WBSCR17	64409	broad.mit.edu	37	chr7	70597882	70597882	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggccaagtgccggcccatcGcggtgcgcagcggagacgcc	16	15	0	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr7:70597882G>A	uc003tvy.2	+	1	94	c.94G>A	c.(94-96)GCG>ACG	p.A32T		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	32	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CCGGCCCATCGCGGTGCGCAG	0.637													A	70597882	A	A	70597882	3	1	239	1	0	0	0	0	1	0	0	0	17261	1087	38	1	96	1	WBSCR17	7	70597882	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	13403530	70597882	88540781	28	17016											
MUC17	140453	broad.mit.edu	37	chr7	100684511	100684511	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgaaggtaccagcatgCcaacctcaactcctagtgaa	8	13	1	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr7:100684511C>T	uc003uxp.1	+	3	9867	c.9814C>T	c.(9814-9816)CCA>TCA	p.P3272S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3272	Extracellular (Potential).|Ser-rich.|53.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCAACCTCAAC	0.502													T	100684511	T	T	100684511	3	4	239	1	0	0	0	0	1	0	0	0	9974	739	26	3	9824	3	MUC17	7	100684511	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	30086629	100684511	58454152	29	17017											
FOXP2	93986	broad.mit.edu	37	chr7	114303551	114303551	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctaccagtttaggctatggaGcagctcttaatgccagtttg	10	9	1	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr7:114303551G>A	uc003vhb.2	+	15	2190	c.1816G>A	c.(1816-1818)GCA>ACA	p.A606T	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.A631T|FOXP2_uc003vha.2_Missense_Mutation_p.A514T|FOXP2_uc011kmu.1_Missense_Mutation_p.A623T|FOXP2_uc011kmv.1_Missense_Mutation_p.A605T|FOXP2_uc010ljz.1_Missense_Mutation_p.A421T|FOXP2_uc003vhe.1_Missense_Mutation_p.A176T	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	606					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						AGGCTATGGAGCAGCTCTTAA	0.303													A	114303551	A	A	114303551	3	1	239	1	0	0	0	0	1	0	0	0	6027	971	34	3	2037	3	FOXP2	7	114303551	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	13619040	114303551	44835112	30	17018											
TMEM209	84928	broad.mit.edu	37	chr7	129843871	129843871	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggagtccccaggctaagaccActttcctagcctctgtttct	8	14	2	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr7:129843871A>C	uc003vpn.2	-	2	206	c.83T>G	c.(82-84)GTG>GGG	p.V28G	TMEM209_uc010lmc.1_Missense_Mutation_p.V28G|TMEM209_uc003vpo.2_Missense_Mutation_p.V28G	NM_032842	NP_116231	Q96SK2	TM209_HUMAN	transmembrane protein 209	28	Helical; (Potential).					integral to membrane				ovary(2)|large_intestine(1)	3	Melanoma(18;0.0435)					GGCTAAGACCACTTTCCTAGC	0.408													C	129843871	C	C	129843871	3	2	239	1	0	0	0	0	1	0	0	0	16131	159	6	5	1658	5	TMEM209	7	129843871	Missense_Mutation	SNP	A	TCGA-32-4213-01A-01D-1353-08	15540320	129843871	29294792	31	17019											
TAS2R5	54429	broad.mit.edu	37	chr7	141490298	141490298	+	Frame_Shift_Del	DEL	T	-	-													caactggtcctcatataaccTcattatcctgggcctggctg							TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr7:141490298delT	uc003vwr.1	+	1	282	c.137delT	c.(136-138)CTCfs	p.L46fs		NM_018980	NP_061853	Q9NYW4	TA2R5_HUMAN	taste receptor T2R5	46	Helical; Name=2; (Potential).				chemosensory behavior|sensory perception of taste		taste receptor activity				0	Melanoma(164;0.0171)					TCATATAACCTCATTATCCTG	0.468													-	141490298	-	-	141490298	7	5	239	1	0	1	0	1	0	0	0	0	15580	1551	54	0	139	0	TAS2R5	7	141490298	Frame_Shift_Del	DEL	T	TCGA-32-4213-01A-01D-1353-08	11646427	141490298	17648365	32	17020											
EPHX2	2053	broad.mit.edu	37	chr8	27362585	27362585	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgacttcctgatagagtcGtgtcaggtgggaatggtcaa	13	6	2	3	rs146337543		TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr8:27362585G>A	uc003xfu.2	+	4	540	c.459G>A	c.(457-459)TCG>TCA	p.S153S	EPHX2_uc010lut.1_Silent_p.S153S|EPHX2_uc010luu.2_Silent_p.S153S|EPHX2_uc010luv.2_Silent_p.S87S|EPHX2_uc003xfv.2_Silent_p.S100S|EPHX2_uc010luw.2_Silent_p.S87S|EPHX2_uc011lam.1_Silent_p.S9S	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	153	Phosphatase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	TGATAGAGTCGTGTCAGGTGG	0.547													A	27362585	A	A	27362585	2	1	239	1	0	0	0	0	0	0	0	1	5180	1132	40	1		1	EPHX2	8	27362585	Silent	SNP	G	TCGA-32-4213-01A-01D-1353-08		27362585	119001437	33	17021											
SLC7A13	157724	broad.mit.edu	37	chr8	87229698	87229698	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaattagaaatccaattttaCcttataaggtatagatagat	6	4	0	3	rs139960114		TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr8:87229698C>T	uc003ydq.1	-	3	1277	c.1179_splice	c.e3+1	p.K393_splice	SLC7A13_uc003ydr.1_Splice_Site_p.K384_splice	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid							integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						TCCAATTTTACCTTATAAGGT	0.289													T	87229698	T	T	87229698	5	4	239	1	0	0	0	0	0	0	1	0	14695	521	18	3	240	3	SLC7A13	8	87229698	Splice_Site	SNP	C	TCGA-32-4213-01A-01D-1353-08	59867113	87229698	59134324	34	17022											
DOCK8	81704	broad.mit.edu	37	chr9	441311	441311	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttatatgagacagttaatgAggtctacaagctggtcatcc	9	8	2	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr9:441311A>G	uc003zgf.2	+	41	5361	c.5249A>G	c.(5248-5250)GAG>GGG	p.E1750G	DOCK8_uc010mgu.2_Missense_Mutation_p.E1052G|DOCK8_uc010mgv.2_Missense_Mutation_p.E1650G|DOCK8_uc003zgk.2_Missense_Mutation_p.E1208G	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1750	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ACAGTTAATGAGGTCTACAAG	0.473													G	441311	G	G	441311	3	3	239	1	0	0	0	0	1	0	0	0	4693	304	11	4	5411	4	DOCK8	9	441311	Missense_Mutation	SNP	A	TCGA-32-4213-01A-01D-1353-08		441311	140772120	35	17023											
UNC13B	10497	broad.mit.edu	37	chr9	35396552	35396552	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagtggctccacaatgaataCgtgcgggatctgcctgtcct	11	11	1	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr9:35396552C>A	uc003zwq.2	+	26	3433	c.3141C>A	c.(3139-3141)TAC>TAA	p.Y1047*	UNC13B_uc003zwr.2_Nonsense_Mutation_p.Y1047*	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1047	MHD1.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			ACAATGAATACGTGCGGGATC	0.552													A	35396552	A	A	35396552	4	1	239	1	0	0	0	0	0	1	0	0	16982	547	19	5	3243	5	UNC13B	9	35396552	Nonsense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	34955241	35396552	105816879	36	17024											
CACNA1B	774	broad.mit.edu	37	chr9	140953153	140953153	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatacttcatcatggccatgAtagccctcaacactgtggtg	8	11	3	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr9:140953153A>G	uc004cog.2	+	29	4586	c.4441A>G	c.(4441-4443)ATA>GTA	p.I1481V	CACNA1B_uc011mfd.1_Missense_Mutation_p.I1011V|CACNA1B_uc004coi.2_Missense_Mutation_p.I695V	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1481	Helical; Name=S1 of repeat IV; (Potential).|IV.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CATGGCCATGATAGCCCTCAA	0.562													G	140953153	G	G	140953153	3	3	239	1	0	0	0	0	1	0	0	0	2539	333	12	4	4555	4	CACNA1B	9	140953153	Missense_Mutation	SNP	A	TCGA-32-4213-01A-01D-1353-08	105556601	140953153	260278	37	17025											
GPRIN2	9721	broad.mit.edu	37	chr10	46999948	46999948	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accagtccgtccctggaagcGcctgcagccctgcatgtgtt	11	15	0	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr10:46999948G>A	uc001jec.2	+	3	1203	c.1068G>A	c.(1066-1068)GCG>GCA	p.A356A	GPRIN2_uc010qfq.1_Silent_p.A119A	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	356											0						CCCTGGAAGCGCCTGCAGCCC	0.677													A	46999948	A	A	46999948	2	1	239	1	0	0	0	0	0	0	0	1	6730	1074	38	1		1	GPRIN2	10	46999948	Silent	SNP	G	TCGA-32-4213-01A-01D-1353-08		46999948	88534799	38	17026											
TYSND1	219743	broad.mit.edu	37	chr10	71905229	71905229	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcttcccgaggggacacgtGccgacaggtcactacaaggc	13	13	1	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr10:71905229G>A	uc001jqr.2	-	1	1268	c.1114C>T	c.(1114-1116)CAC>TAC	p.H372Y	TYSND1_uc001jqq.2_Intron|TYSND1_uc001jqs.2_Missense_Mutation_p.H372Y|TYSND1_uc001jqt.2_Intron	NM_173555	NP_775826	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1 isoform a	372	Serine protease.	Charge relay system (By similarity).			proteolysis	peroxisome	serine-type endopeptidase activity			large_intestine(1)	1						GGGGACACGTGCCGACAGGTC	0.677													A	71905229	A	A	71905229	3	1	239	1	0	0	0	0	1	0	0	0	16814	1319	46	3	602	3	TYSND1	10	71905229	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	24905281	71905229	63629518	39	17027											
PTEN	5728	broad.mit.edu	37	chr10	89720805	89720806	+	Frame_Shift_Ins	INS	-	T	T													aaggaatatctagtacttacINStttaacaaaaaatgatcttg							TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr10:89720805_89720806insT	uc001kfb.2	+	9	1987_1988	c.956_957insT	c.(955-957)ACTfs	p.T319fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	319	C2 tensin-type.		Missing (in glioma; reduced tumor suppressor activity; fails to inactivate AKT/PKB).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.T319fs*1(22)|p.L318fs*2(11)|p.T319fs*6(6)|p.R55fs*1(4)|p.T319fs*24(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.T319del(2)|p.T319_K332del(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.L316fs*1(1)|p.T319fs*4(1)|p.T319fs*5(1)|p.W274_F341del(1)|p.V317_K322del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTAGTACTTACTTTAACAAAAA	0.332		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89720806	T	T	89720805	7	5	239	1	0	1	1	0	0	0	0	0	12738	565	20	0	986	0	PTEN	10	89720805	Frame_Shift_Ins	INS	-	TCGA-32-4213-01A-01D-1353-08	17815576	89720805	45813942	40	17028											
TAF5	6877	broad.mit.edu	37	chr10	105145152	105145152	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcaaacatttacttgtttGgtgggatataaaggacacaa	8	6	1	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr10:105145152G>A	uc001kwv.2	+	8	1757	c.1734G>A	c.(1732-1734)TTG>TTA	p.L578L	TAF5_uc010qqq.1_Intron	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	578	WD 2.				histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		TTACTTGTTTGGTGGGATATA	0.423													A	105145152	A	A	105145152	2	1	239	1	0	0	0	0	0	0	0	1	15525	1339	47	3		3	TAF5	10	105145152	Silent	SNP	G	TCGA-32-4213-01A-01D-1353-08	15424347	105145152	30389595	41	17029											
TCF7L2	6934	broad.mit.edu	37	chr10	114711317	114711317	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcatcatgatccccgaccTgacgagcccctacctcccca	5	20	2	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr10:114711317T>C	uc001lae.3	+	3	839	c.332T>C	c.(331-333)CTG>CCG	p.L111P	TCF7L2_uc001lac.3_Missense_Mutation_p.L111P|TCF7L2_uc010qrk.1_Missense_Mutation_p.L111P|TCF7L2_uc010qrl.1_Missense_Mutation_p.L111P|TCF7L2_uc010qrm.1_Missense_Mutation_p.L111P|TCF7L2_uc010qrn.1_Missense_Mutation_p.L111P|TCF7L2_uc001lad.3_Missense_Mutation_p.L111P|TCF7L2_uc001lag.3_Missense_Mutation_p.L111P|TCF7L2_uc001laf.3_Missense_Mutation_p.L111P|TCF7L2_uc010qro.1_Missense_Mutation_p.L111P|TCF7L2_uc001lah.2_Missense_Mutation_p.L111P|TCF7L2_uc010qrp.1_Missense_Mutation_p.L111P|TCF7L2_uc010qrq.1_Missense_Mutation_p.L111P|TCF7L2_uc010qrr.1_Missense_Mutation_p.L5P|TCF7L2_uc010qrs.1_Missense_Mutation_p.L5P|TCF7L2_uc010qrt.1_Missense_Mutation_p.L5P	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	111					anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		ATCCCCGACCTGACGAGCCCC	0.532													C	114711317	C	C	114711317	3	2	239	1	0	0	0	0	1	0	0	0	15695	1580	55	4	342	4	TCF7L2	10	114711317	Missense_Mutation	SNP	T	TCGA-32-4213-01A-01D-1353-08	9566165	114711317	20823430	42	17030											
CD6	923	broad.mit.edu	37	chr11	60785322	60785322	+	Silent	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ctgggccctcagtatcacccGaggagcaacagtgagtcgag	13	12	2	1	rs137857404		TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr11:60785322G>C	uc001nqq.2	+	11	1897	c.1674G>C	c.(1672-1674)CCG>CCC	p.P558P	CD6_uc001nqp.2_Silent_p.P558P|CD6_uc001nqr.2_Silent_p.P526P|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Silent_p.P517P	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	558	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						AGTATCACCCGAGGAGCAACA	0.552													C	60785322	C	C	60785322	2	2	239	1	0	0	0	0	0	0	0	1	3028	1045	37	5		5	CD6	11	60785322	Silent	SNP	G	TCGA-32-4213-01A-01D-1353-08		60785322	74221194	43	17031											
ARHGEF17	9828	broad.mit.edu	37	chr11	73076830	73076830	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccagtgctggtgtcgtcctcAccatgcccacttcgcccggt	10	17	1	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr11:73076830A>T	uc001otu.2	+	20	5854	c.5833A>T	c.(5833-5835)ACC>TCC	p.T1945S		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1945					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						TGTCGTCCTCACCATGCCCAC	0.657													T	73076830	T	T	73076830	3	4	239	1	0	0	0	0	1	0	0	0	900	159	6	5	5911	5	ARHGEF17	11	73076830	Missense_Mutation	SNP	A	TCGA-32-4213-01A-01D-1353-08	12291508	73076830	61929686	44	17032											
KDM4D	55693	broad.mit.edu	37	chr11	94731887	94731887	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccacccgtcaaatggcagaCgtggtcgtggtcgccctcct	11	15	1	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr11:94731887C>T	uc001pfe.2	+	3	2183	c.1351C>T	c.(1351-1353)CGT>TGT	p.R451C		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	451					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AAATGGCAGACGTGGTCGTGG	0.602													T	94731887	T	T	94731887	3	4	239	1	0	0	0	0	1	0	0	0	8131	536	19	1	1353	1	KDM4D	11	94731887	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	21655057	94731887	40274629	45	17033											
LST-3TM12	338821	broad.mit.edu	37	chr12	21201833	21201833	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gttgccggcctaaccttgacCtatgatgggtttgtatatat	10	8	0	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr12:21201833C>A	uc010sin.1	+	8	1182	c.1182C>A	c.(1180-1182)ACC>ACA	p.T394T	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Silent_p.T441T	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	394						membrane	transporter activity				0						TAACCTTGACCTATGATGGGT	0.318													A	21201833	A	A	21201833	2	1	239	1	0	0	0	0	0	0	0	1	9066	668	24	5		5	LST-3TM12	12	21201833	Silent	SNP	C	TCGA-32-4213-01A-01D-1353-08		21201833	112650062	46	17034											
AAAS	8086	broad.mit.edu	37	chr12	53709176	53709176	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccatcgacagagtgccagGgcccagccggatgccgtctt	13	15	1	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr12:53709176G>A	uc001scr.3	-	4	505	c.342C>T	c.(340-342)GCC>GCT	p.A114A	AAAS_uc001scs.3_Silent_p.A114A	NM_015665	NP_056480	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency,	114					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				ovary(1)	1						AGAGTGCCAGGGCCCAGCCGG	0.562													A	53709176	A	A	53709176	2	1	239	1	0	0	0	0	0	0	0	1	8	1219	43	3		3	AAAS	12	53709176	Silent	SNP	G	TCGA-32-4213-01A-01D-1353-08	32507343	53709176	80142719	47	17035											
POC1B	282809	broad.mit.edu	37	chr12	89864247	89864247	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tacccgaaggatggaatgatAtgcaattaactccaccgctg	9	10	0	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr12:89864247A>G	uc001tbc.2	-	7	806	c.701T>C	c.(700-702)ATA>ACA	p.I234T	POC1B_uc001tba.2_Missense_Mutation_p.I192T|POC1B_uc001tbb.2_Missense_Mutation_p.I104T|POC1B_uc010sun.1_RNA|POC1B_uc009zsp.2_RNA|POC1B_uc009zsq.2_Intron	NM_172240	NP_758440	Q8TC44	POC1B_HUMAN	WD repeat domain 51B	234	WD 6.				cell projection organization	centriole|microtubule basal body				ovary(1)	1						ATGGAATGATATGCAATTAAC	0.388													G	89864247	G	G	89864247	3	3	239	1	0	0	0	0	1	0	0	0	12176	449	16	4	759	4	POC1B	12	89864247	Missense_Mutation	SNP	A	TCGA-32-4213-01A-01D-1353-08	36155071	89864247	43987648	48	17036											
TESC	54997	broad.mit.edu	37	chr12	117486887	117486887	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catggtggtgtcgatgggccGgaagtaggacatgatggtca	17	6	1	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr12:117486887G>A	uc001twh.2	-	4	450	c.445C>T	c.(445-447)CGG>TGG	p.R149W	TESC_uc001twi.2_RNA	NM_017899	NP_060369	Q96BS2	TESC_HUMAN	tescalcin	96					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding				0	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		TCGATGGGCCGGAAGTAGGAC	0.587													A	117486887	A	A	117486887	3	1	239	1	0	0	0	0	1	0	0	0	15763	1115	39	2	378	2	TESC	12	117486887	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	27622640	117486887	16365008	49	17037											
SBNO1	55206	broad.mit.edu	37	chr12	123780522	123780522	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atagctgtttctgttggaccGcaagctgttgagactggtct	12	8	2	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr12:123780522G>A	uc010tap.1	-	31	4115	c.4115C>T	c.(4114-4116)GCG>GTG	p.A1372V	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.A1371V|SBNO1_uc010taq.1_Missense_Mutation_p.A323V	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1372							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CTGTTGGACCGCAAGCTGTTG	0.433													A	123780522	A	A	123780522	3	1	239	1	0	0	0	0	1	0	0	0	13862	1087	38	1	70	1	SBNO1	12	123780522	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	6293635	123780522	10071373	50	17038											
GLT1D1	144423	broad.mit.edu	37	chr12	129360490	129360490	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggctgcagggcacgtgtgcGttttgaaggatgcctttgac	15	8	0	2	rs146263464	byFrequency	TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr12:129360490G>A	uc010tbh.1	+	2	76	c.67G>A	c.(67-69)GTT>ATT	p.V23I	GLT1D1_uc001uhx.1_Missense_Mutation_p.V34I|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	34					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		GCACGTGTGCGTTTTGAAGGA	0.473													A	129360490	A	A	129360490	3	1	239	1	0	0	0	0	1	0	0	0	6465	1145	40	1	106	1	GLT1D1	12	129360490	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	5579968	129360490	4491405	51	17039											
TUBA3C	7278	broad.mit.edu	37	chr13	19751585	19751585	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgtagggctccaccacggCcgtggagacctggggggctg	18	11	0	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr13:19751585C>T	uc009zzj.2	-	4	587	c.538G>A	c.(538-540)GCC>ACC	p.A180T		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	180					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TCCACCACGGCCGTGGAGACC	0.547													T	19751585	T	T	19751585	3	4	239	1	0	0	0	0	1	0	0	0	16743	739	26	3	822	3	TUBA3C	13	19751585	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08		19751585	95418293	52	17040											
RB1	5925	broad.mit.edu	37	chr13	48954327	48954328	+	Frame_Shift_Del	DEL	AT	-	-													tctgaatgacaacatttttcAtatgtctttattggcgtgcg					rs5803433		TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr13:48954327_48954328delAT	uc001vcb.2	+	16	1614_1615	c.1448_1449delAT	c.(1447-1449)CATfs	p.H483fs		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	483	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.H483fs*9(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AACATTTTTCATATGTCTTTAT	0.203		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			-	48954328	-	-	48954327	7	5	239	1	0	1	0	1	0	0	0	0	13098	217	8	0	1510	0	RB1	13	48954327	Frame_Shift_Del	DEL	AT	TCGA-32-4213-01A-01D-1353-08	29202742	48954327	66215551	53	17041											
FLJ10357	55701	broad.mit.edu	37	chr14	21552177	21552179	+	In_Frame_Del	DEL	CTG	-	-													aagaggcccgtggcagagacCtgctggccgtggaggcggtg							TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr14:21552177_21552179delCTG	uc001vzp.2	+	17	3786_3788	c.3757_3759delCTG	c.(3757-3759)CTGdel	p.L1254del	FLJ10357_uc001vzo.1_In_Frame_Del_p.L333del|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_In_Frame_Del_p.L540del	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	1254					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		TGGCAGAGACCTGCTGGCCGTGG	0.606													-	21552179	-	-	21552177	7	5	239	1	0	1	0	1	0	0	0	0	5926	680	24	0	3823	0	FLJ10357	14	21552177	In_Frame_Del	DEL	CTG	TCGA-32-4213-01A-01D-1353-08		21552177	85797363	54	17042											
HOMEZ	57594	broad.mit.edu	37	chr14	23746303	23746303	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtagctcctcagagattggaGggaggcagatgagccccgct	15	10	1	3			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr14:23746303G>A	uc001wja.2	-	2	282	c.134C>T	c.(133-135)CCT>CTT	p.P45L	HOMEZ_uc001wjb.2_Missense_Mutation_p.P47L	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	45						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		AGAGATTGGAGGGAGGCAGAT	0.532													A	23746303	A	A	23746303	3	1	239	1	0	0	0	0	1	0	0	0	7281	1000	35	3	1522	3	HOMEZ	14	23746303	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	2194126	23746303	83603237	55	17043											
ADAM20	8748	broad.mit.edu	37	chr14	70990596	70990596	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgaaaagatgtgcaacatcAtgttgtagtcgattattaag	9	4	1	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr14:70990596A>G	uc001xme.2	-	2	1274	c.1029T>C	c.(1027-1029)CAT>CAC	p.H343H		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	293	Peptidase M12B.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GTGCAACATCATGTTGTAGTC	0.368													G	70990596	G	G	70990596	2	3	239	1	0	0	0	0	0	0	0	1	242	214	8	4		4	ADAM20	14	70990596	Silent	SNP	A	TCGA-32-4213-01A-01D-1353-08	47244293	70990596	36358944	56	17044											
CDC42BPB	9578	broad.mit.edu	37	chr14	103447154	103447154	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cacgtcgaagttggatgtgtCagagggactgctcacatcag	13	9	3	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr14:103447154C>A	uc001ymi.1	-	8	1328	c.1096G>T	c.(1096-1098)GAC>TAC	p.D366Y		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	366	AGC-kinase C-terminal.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TTGGATGTGTCAGAGGGACTG	0.463													A	103447154	A	A	103447154	3	1	239	1	0	0	0	0	1	0	0	0	3073	826	29	5	4159	5	CDC42BPB	14	103447154	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	32456558	103447154	3902386	57	17045											
AHNAK2	113146	broad.mit.edu	37	chr14	105415172	105415172	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaccttcacgtcggcggaaaGgggctgaatgctgaggtcag	16	9	2	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr14:105415172G>T	uc010axc.1	-	7	6736	c.6616C>A	c.(6616-6618)CTT>ATT	p.L2206I	AHNAK2_uc001ypx.2_Missense_Mutation_p.L2106I	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2206						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCGGCGGAAAGGGGCTGAATG	0.642													T	105415172	T	T	105415172	3	4	239	1	0	0	0	0	1	0	0	0	415	1000	35	5	10775	5	AHNAK2	14	105415172	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	1968018	105415172	1934368	58	17046											
RYR3	6263	broad.mit.edu	37	chr15	34080624	34080624	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgcagagatctctatgccttCtaccccatgctgatccgcta	7	14	2	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr15:34080624C>T	uc001zhi.2	+	67	9865	c.9795C>T	c.(9793-9795)TTC>TTT	p.F3265F	RYR3_uc010bar.2_Silent_p.F3265F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3265					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCTATGCCTTCTACCCCATGC	0.557													T	34080624	T	T	34080624	2	4	239	1	0	0	0	0	0	0	0	1	13770	912	32	3		3	RYR3	15	34080624	Silent	SNP	C	TCGA-32-4213-01A-01D-1353-08		34080624	68450768	59	17047											
MAN2A2	4122	broad.mit.edu	37	chr15	91454437	91454437	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcacgacgccctcccagagCgcacggtgatccagctggat	12	15	1	2	rs114870914	by1000genomes	TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr15:91454437C>T	uc010bnz.2	+	13	2027	c.1912C>T	c.(1912-1914)CGC>TGC	p.R638C	MAN2A2_uc010boa.2_Missense_Mutation_p.R680C|MAN2A2_uc002bqc.2_Missense_Mutation_p.R638C|MAN2A2_uc010uql.1_Missense_Mutation_p.R300C|MAN2A2_uc010uqm.1_Missense_Mutation_p.R217C|MAN2A2_uc010uqn.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	638	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CCTCCCAGAGCGCACGGTGAT	0.617													T	91454437	T	T	91454437	3	4	239	1	0	0	0	0	1	0	0	0	9215	768	27	1	1958	1	MAN2A2	15	91454437	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	57373813	91454437	11076955	60	17048											
ADCY9	115	broad.mit.edu	37	chr16	4042213	4042213	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggatgttcttgaacctcagcGgaaggagagccgactggtcc	14	10	2	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr16:4042213G>T	uc002cvx.2	-	5	2680	c.2141C>A	c.(2140-2142)CCG>CAG	p.P714Q		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	714	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						GAACCTCAGCGGAAGGAGAGC	0.542													T	4042213	T	T	4042213	3	4	239	1	0	0	0	0	1	0	0	0	301	1116	39	5	1948	5	ADCY9	16	4042213	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08		4042213	86312540	61	17049											
SOCS1	8651	broad.mit.edu	37	chr16	11348719	11348719	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gtcaaatctggaaggggaagGagctcaggtagtcgcggagg	18	6	3	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr16:11348719G>T	uc002dar.1	-	2	771	c.617C>A	c.(616-618)TCC>TAC	p.S206Y	C16orf75_uc002daq.1_Intron	NM_003745	NP_003736	O15524	SOCS1_HUMAN	suppressor of cytokine signaling 1	206	SOCS box.				interferon-gamma-mediated signaling pathway|JAK-STAT cascade|negative regulation of insulin receptor signaling pathway|negative regulation of tyrosine phosphorylation of Stat3 protein|regulation of growth|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol	insulin-like growth factor receptor binding|protein kinase binding|protein kinase inhibitor activity	p.S206P(1)|p.R127_*212del(1)		haematopoietic_and_lymphoid_tissue(64)|lung(3)|breast(1)|central_nervous_system(1)	69						GAAGGGGAAGGAGCTCAGGTA	0.627			F|O		Hodgkin Lymphoma|PMBL								T	11348719	T	T	11348719	3	4	239	1	0	0	0	0	1	0	0	0	14913	1174	41	5	22	5	SOCS1	16	11348719	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	7306506	11348719	79006034	62	17050											
SEZ6L2	26470	broad.mit.edu	37	chr16	29908260	29908260	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcagggctgggtgggggtgGggctgtggttcctgggggcg	26	6	0	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr16:29908260G>A	uc002duq.3	-	3	634	c.394C>T	c.(394-396)CCA>TCA	p.P132S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Intron|SEZ6L2_uc002dur.3_Intron|SEZ6L2_uc002dus.3_Missense_Mutation_p.P132S|SEZ6L2_uc010vec.1_Missense_Mutation_p.P132S|SEZ6L2_uc010ved.1_Missense_Mutation_p.P88S	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	132	Pro-rich.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GGTGGGGGTGGGGCTGTGGTT	0.687													A	29908260	A	A	29908260	3	1	239	1	0	0	0	0	1	0	0	0	14144	1232	43	3	2441	3	SEZ6L2	16	29908260	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	18559541	29908260	60446493	63	17051											
CHD9	80205	broad.mit.edu	37	chr16	53358755	53358755	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agctgatgcttcatctggatCtgatagtacatcgtcgtcat	9	9	4	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr16:53358755C>A	uc002ehb.2	+	38	8806	c.8642C>A	c.(8641-8643)TCT>TAT	p.S2881Y	CHD9_uc002egy.2_Missense_Mutation_p.S2865Y|CHD9_uc002ehc.2_Missense_Mutation_p.S2866Y|CHD9_uc002ehf.2_Missense_Mutation_p.S1979Y|CHD9_uc010cbw.2_Missense_Mutation_p.S947Y	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2881	Poly-Ser.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TCATCTGGATCTGATAGTACA	0.388													A	53358755	A	A	53358755	3	1	239	1	0	0	0	0	1	0	0	0	3332	913	32	5	8744	5	CHD9	16	53358755	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	23450495	53358755	36995998	64	17052											
CDH8	1006	broad.mit.edu	37	chr16	61687800	61687800	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccttgccttggcataaactgCaaatctggtttaatatcctt	6	10	1	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr16:61687800C>A	uc002eog.1	-	12	2364	c.2112G>T	c.(2110-2112)TTG>TTT	p.L704F		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	704	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GCATAAACTGCAAATCTGGTT	0.428													A	61687800	A	A	61687800	3	1	239	1	0	0	0	0	1	0	0	0	3116	709	25	5	291	5	CDH8	16	61687800	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	8329045	61687800	28666953	65	17053											
DPH1	1801	broad.mit.edu	37	chr17	1936938	1936938	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atctggaggatccaacaagcCcaggccaagaagggtgagcc	13	11	1	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr17:1936938C>A	uc002fts.2	+	2	234	c.216C>A	c.(214-216)GCC>GCA	p.A72A	DPH1_uc002ftr.1_RNA|DPH1_uc002ftt.2_Silent_p.A67A|DPH1_uc010cjx.2_5'UTR|DPH1_uc010vqs.1_Silent_p.A82A	NM_001383	NP_001374	Q9BZG8	DPH1_HUMAN	diptheria toxin resistance protein required for	72					peptidyl-diphthamide biosynthetic process from peptidyl-histidine|translation	cytoplasm|nucleus				pancreas(1)	1						TCCAACAAGCCCAGGCCAAGA	0.582													A	1936938	A	A	1936938	2	1	239	1	0	0	0	0	0	0	0	1	4719	610	22	5		5	DPH1	17	1936938	Silent	SNP	C	TCGA-32-4213-01A-01D-1353-08		1936938	79258272	66	17054											
KRT38	8687	broad.mit.edu	37	chr17	39594785	39594785	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccacctccagggcattcacCgtgcatctcagctccaggat	8	16	2	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr17:39594785C>T	uc002hwq.1	-	5	1401	c.978G>A	c.(976-978)ACG>ACA	p.T326T		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	326	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				GGGCATTCACCGTGCATCTCA	0.597													T	39594785	T	T	39594785	2	4	239	1	0	0	0	0	0	0	0	1	8475	639	23	2		2	KRT38	17	39594785	Silent	SNP	C	TCGA-32-4213-01A-01D-1353-08	37657847	39594785	41600425	67	17055											
KRT16	3868	broad.mit.edu	37	chr17	39768925	39768925	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggaggaggtgaactggcGgctgcaggtggtcatggtgc	20	7	1	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr17:39768925G>A	uc002hxg.3	-	1	155	c.16C>T	c.(16-18)CGC>TGC	p.R6C	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	6	Head.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				GTGAACTGGCGGCTGCAGGTG	0.657													A	39768925	A	A	39768925	3	1	239	1	0	0	0	0	1	0	0	0	8453	1116	39	2	1437	2	KRT16	17	39768925	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	174140	39768925	41426285	68	17056											
KLHL11	55175	broad.mit.edu	37	chr17	40010614	40010614	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcggcaatgtatacaaacCggtcttcaatggctagtgct	12	9	2	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr17:40010614C>T	uc002hyf.1	-	2	1511	c.1505G>A	c.(1504-1506)CGG>CAG	p.R502Q		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	kelch-like 11 precursor	502						extracellular region					0		Breast(137;0.00156)				GTATACAAACCGGTCTTCAAT	0.443													T	40010614	T	T	40010614	3	4	239	1	0	0	0	0	1	0	0	0	8367	652	23	2	625	2	KLHL11	17	40010614	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	241689	40010614	41184596	69	17057											
NPTX1	4884	broad.mit.edu	37	chr17	78447110	78447110	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtgcccacacctggcgtggCgctggacttgagccacatgc	13	15	0	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr17:78447110C>T	uc002jyp.1	-	3	945	c.787G>A	c.(787-789)GCC>ACC	p.A263T		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	263	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			CCTGGCGTGGCGCTGGACTTG	0.587													T	78447110	T	T	78447110	3	4	239	1	0	0	0	0	1	0	0	0	10602	768	27	1	523	1	NPTX1	17	78447110	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	38436496	78447110	2748100	70	17058											
POTEC	388468	broad.mit.edu	37	chr18	14533125	14533125	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatagatcttgagaagatacAtcaacattttgctcaaggag	9	6	3	3			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr18:14533125A>G	uc010dln.2	-	5	1444	c.990T>C	c.(988-990)GAT>GAC	p.D330D	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	330	ANK 6.									skin(3)	3						GAGAAGATACATCAACATTTT	0.373													G	14533125	G	G	14533125	2	3	239	1	0	0	0	0	0	0	0	1	12262	214	8	4		4	POTEC	18	14533125	Silent	SNP	A	TCGA-32-4213-01A-01D-1353-08		14533125	63544123	71	17059											
STXBP2	6813	broad.mit.edu	37	chr19	7707143	7707143	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaccgggcagctgaccccGtgtccccactactgcatgag	12	15	0	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr19:7707143G>A	uc002mha.3	+	9	763	c.718G>A	c.(718-720)GTG>ATG	p.V240M	STXBP2_uc002mhb.3_Missense_Mutation_p.V237M|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Missense_Mutation_p.V251M|STXBP2_uc010dvk.2_Missense_Mutation_p.V208M|STXBP2_uc002mhc.3_Missense_Mutation_p.V8M|STXBP2_uc002mhe.1_5'Flank	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	240					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						AGCTGACCCCGTGTCCCCACT	0.607													A	7707143	A	A	7707143	3	1	239	1	0	0	0	0	1	0	0	0	15352	1145	40	1	752	1	STXBP2	19	7707143	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08		7707143	51421840	72	17060											
USE1	55850	broad.mit.edu	37	chr19	17330166	17330166	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaagaccaataccctggcCgcccagagtgtcatcaagaa	8	14	3	3			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr19:17330166C>T	uc002nfo.2	+	7	627	c.567C>T	c.(565-567)GCC>GCT	p.A189A	USE1_uc010eal.1_Intron	NM_018467	NP_060937	Q9NZ43	USE1_HUMAN	unconventional SNARE in the ER 1 homolog	189	Cytoplasmic (Potential).|Potential.				lysosomal transport|protein catabolic process|protein transport|secretion by cell|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	protein binding				0						ATACCCTGGCCGcccagagtg	0.303													T	17330166	T	T	17330166	2	4	239	1	0	0	0	0	0	0	0	1	17028	639	23	2		2	USE1	19	17330166	Silent	SNP	C	TCGA-32-4213-01A-01D-1353-08	9623023	17330166	41798817	73	17061											
ZNF85	7639	broad.mit.edu	37	chr19	21131689	21131689	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgtgaaagtatggatgaGtgtaagatgcacaaaggagg	16	3	0	3			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr19:21131689G>A	uc002npg.3	+	4	496	c.369G>A	c.(367-369)GAG>GAA	p.E123E	ZNF85_uc010ecn.2_Silent_p.E58E|ZNF85_uc010eco.2_Silent_p.E71E|ZNF85_uc002npi.2_Silent_p.E64E	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	123						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						GTATGGATGAGTGTAAGATGC	0.328													A	21131689	A	A	21131689	2	1	239	1	0	0	0	0	0	0	0	1	18190	1020	36	3		3	ZNF85	19	21131689	Silent	SNP	G	TCGA-32-4213-01A-01D-1353-08	3801523	21131689	37997294	74	17062											
MLL4	9757	broad.mit.edu	37	chr19	36223857	36223857	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggccctagagaggagtcacTccccccggcgcctcccctgg	12	18	1	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr19:36223857T>A	uc010eei.2	+	29	6407	c.6407T>A	c.(6406-6408)CTC>CAC	p.L2136H		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2136					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGGAGTCACTCCCCCCGGCG	0.662													A	36223857	A	A	36223857	3	1	239	1	0	0	0	0	1	0	0	0	9623	1551	54	5	6517	5	MLL4	19	36223857	Missense_Mutation	SNP	T	TCGA-32-4213-01A-01D-1353-08	15092168	36223857	22905126	75	17063											
TPTE	7179	broad.mit.edu	37	chr21	10934961	10934961	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tagattgtagactcgatagtGgtttcggtgtttcttatcta	10	5	2	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr21:10934961G>T	uc002yip.1	-	15	1200	c.832C>A	c.(832-834)CAC>AAC	p.H278N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.H260N|TPTE_uc002yir.1_Missense_Mutation_p.H240N|TPTE_uc010gkv.1_Missense_Mutation_p.H140N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	278	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTCGATAGTGGTTTCGGTGT	0.348													T	10934961	T	T	10934961	3	4	239	1	0	0	0	0	1	0	0	0	16427	1348	47	5	863	5	TPTE	21	10934961	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08		10934961	37194934	76	17064											
C21orf7	56911	broad.mit.edu	37	chr21	30547106	30547106	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgagctggttcgggaattcGaggctctgacggaggagaat	16	7	1	3			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr21:30547106G>A	uc002yne.2	+	8	893	c.622G>A	c.(622-624)GAG>AAG	p.E208K	C21orf7_uc011acr.1_RNA|C21orf7_uc002ynd.2_RNA|C21orf7_uc010gln.2_RNA|C21orf7_uc002ynf.2_Missense_Mutation_p.E208K|C21orf7_uc010glo.2_Missense_Mutation_p.E53K|C21orf7_uc002yng.2_Missense_Mutation_p.E108K|C21orf7_uc010glp.2_RNA	NM_020152	NP_064537	P57077	TAK1L_HUMAN	chromosome 21 open reading frame 7	208						cytosol|nucleus	protein binding			ovary(2)	2				Colorectal(56;0.248)		TCGGGAATTCGAGGCTCTGAC	0.517													A	30547106	A	A	30547106	3	1	239	1	0	0	0	0	1	0	0	0	2132	1059	37	2	648	2	C21orf7	21	30547106	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	19612145	30547106	17582789	77	17065											
SON	6651	broad.mit.edu	37	chr21	34925244	34925244	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttattcagtgtcagcatcagAtccctcagttttagtatcag	7	9	5	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr21:34925244A>G	uc002yse.1	+	3	3756	c.3707A>G	c.(3706-3708)GAT>GGT	p.D1236G	SON_uc002ysb.1_Missense_Mutation_p.D1236G|SON_uc002ysc.2_Missense_Mutation_p.D1236G|SON_uc002ysd.2_Missense_Mutation_p.D227G|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.D227G	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1236					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TCAGCATCAGATCCCTCAGTT	0.478													G	34925244	G	G	34925244	3	3	239	1	0	0	0	0	1	0	0	0	14926	333	12	4	3717	4	SON	21	34925244	Missense_Mutation	SNP	A	TCGA-32-4213-01A-01D-1353-08	4378138	34925244	13204651	78	17066											
TRAPPC10	7109	broad.mit.edu	37	chr21	45503036	45503036	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acgactgggattatctgcagAaacgtccacatgctcctgag	10	11	1	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr21:45503036A>G	uc002zea.2	+	14	2260	c.2091A>G	c.(2089-2091)AGA>AGG	p.R697R	TRAPPC10_uc010gpo.2_Silent_p.R408R|TRAPPC10_uc011afa.1_Silent_p.R116R	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	697					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TTATCTGCAGAAACGTCCACA	0.547													G	45503036	G	G	45503036	2	3	239	1	0	0	0	0	0	0	0	1	16454	243	9	4		4	TRAPPC10	21	45503036	Silent	SNP	A	TCGA-32-4213-01A-01D-1353-08	10577792	45503036	2626859	79	17067											
COL6A2	1292	broad.mit.edu	37	chr21	47531965	47531965	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtcaccatgcagtcccccaCggacatcctgctcttccaca	6	19	2	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr21:47531965C>T	uc002zia.1	+	3	270	c.188C>T	c.(187-189)ACG>ATG	p.T63M	COL6A2_uc002zhy.1_Missense_Mutation_p.T63M|COL6A2_uc002zhz.1_Missense_Mutation_p.T63M|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	63	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CAGTCCCCCACGGACATCCTG	0.612													T	47531965	T	T	47531965	3	4	239	1	0	0	0	0	1	0	0	0	3700	536	19	1	194	1	COL6A2	21	47531965	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	2028929	47531965	597930	80	17068											
YDJC	150223	broad.mit.edu	37	chr22	21984158	21984158	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgcgggccagctccgccGcgctctccgtggccgcaccg	13	20	1	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr22:21984158G>A	uc002zvb.2	-	1	183	c.146C>T	c.(145-147)GCG>GTG	p.A49V	YDJC_uc002zvc.2_RNA|YDJC_uc002zvd.2_Missense_Mutation_p.A49V|CCDC116_uc011aih.1_5'Flank|CCDC116_uc002zve.2_5'Flank	NM_001017964	NP_001017964	A8MPS7	YDJC_HUMAN	YdjC homolog	49					carbohydrate metabolic process		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds				0	Colorectal(54;0.105)					CAGCTCCGCCGCGCTCTCCGT	0.731													A	21984158	A	A	21984158	3	1	239	1	0	0	0	0	1	0	0	0	17468	1087	38	1	845	1	YDJC	22	21984158	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08		21984158	29320408	81	17069											
TYMP	1890	broad.mit.edu	37	chr22	50967631	50967631	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgtcacccacaccccctgtGgaatgcttgtccacaagctg	8	15	1	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chr22:50967631G>A	uc003bmb.3	-	2	471	c.351C>T	c.(349-351)TCC>TCT	p.S117S	TYMP_uc003bmc.3_Silent_p.S117S|TYMP_uc003bmd.3_Silent_p.S117S|TYMP_uc010hbd.2_Silent_p.S117S|TYMP_uc003bme.3_Silent_p.S117S|TYMP_uc003bmf.3_Silent_p.S117S|TYMP_uc011arz.1_Silent_p.S117S	NM_001113756	NP_001107228	P19971	TYPH_HUMAN	endothelial cell growth factor 1	117					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			ovary(1)	1		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	CACCCCCTGTGGAATGCTTGT	0.637													A	50967631	A	A	50967631	2	1	239	1	0	0	0	0	0	0	0	1	16808	1335	47	3		3	TYMP	22	50967631	Silent	SNP	G	TCGA-32-4213-01A-01D-1353-08	28983473	50967631	336935	82	17070											
FAM9A	171482	broad.mit.edu	37	chrX	8766427	8766427	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gttcatctttttcagcaaaaGgttctctttccccatgctca	5	12	5	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chrX:8766427G>T	uc004csg.2	-	4	425	c.314C>A	c.(313-315)CCT>CAT	p.P105H		NM_174951	NP_777611	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	105						nucleolus					0		Hepatocellular(5;0.219)				TTCAGCAAAAGGTTCTCTTTC	0.423													T	8766427	T	T	8766427	3	4	239	1	0	0	0	0	1	0	0	0	5659	1000	35	5	708	5	FAM9A	23	8766427	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08		8766427	146504133	83	17071											
MED14	9282	broad.mit.edu	37	chrX	40562700	40562700	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatttagtaacttaccaagTccataaagcatcaattgaaa	4	8	2	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chrX:40562700T>C	uc004dex.3	-	11	1547	c.1407A>G	c.(1405-1407)GGA>GGG	p.G469G		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	469	Interaction with STAT2.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						ACTTACCAAGTCCATAAAGCA	0.303													C	40562700	C	C	40562700	2	2	239	1	0	0	0	0	0	0	0	1	9432	1654	58	4		4	MED14	23	40562700	Silent	SNP	T	TCGA-32-4213-01A-01D-1353-08	31796273	40562700	114707860	84	17072											
PFKFB1	5207	broad.mit.edu	37	chrX	54986282	54986282	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caacatgaccttcctcatggCtgagatagttgtgaacatcc	8	11	1	3			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chrX:54986282C>T	uc004dty.1	-	4	433	c.362G>A	c.(361-363)AGC>AAC	p.S121N	PFKFB1_uc010nkd.1_Missense_Mutation_p.S107N|PFKFB1_uc011mol.1_Missense_Mutation_p.S56N	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	121	6-phosphofructo-2-kinase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						TTCCTCATGGCTGAGATAGTT	0.388													T	54986282	T	T	54986282	3	4	239	1	0	0	0	0	1	0	0	0	11760	797	28	3	1097	3	PFKFB1	23	54986282	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	14423582	54986282	100284278	85	17073											
SPIN3	169981	broad.mit.edu	37	chrX	57020821	57020821	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattggaatcttgaaggatgCggaggtcaccatctttataa	10	7	3	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chrX:57020821C>T	uc010nkj.2	-	2	846	c.560G>A	c.(559-561)CGC>CAC	p.R187H	SPIN3_uc004duu.3_Intron|SPIN3_uc004duw.3_Intron|SPIN3_uc004duv.3_Intron|SPIN3_uc004dux.1_Missense_Mutation_p.R187H	NM_001010862	NP_001010862	Q5JUX0	SPIN3_HUMAN	spindlin family, member 3	187					gamete generation					ovary(1)|central_nervous_system(1)	2						TTGAAGGATGCGGAGGTCACC	0.443													T	57020821	T	T	57020821	3	4	239	1	0	0	0	0	1	0	0	0	15054	768	27	1	220	1	SPIN3	23	57020821	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	2034539	57020821	98249739	86	17074											
ZC3H12B	340554	broad.mit.edu	37	chrX	64722249	64722249	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gacttctccaaactgaacatCaacagcatgcataaccgaga	6	12	2	2			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chrX:64722249C>T	uc010nko.2	+	5	1647	c.1638C>T	c.(1636-1638)ATC>ATT	p.I546I		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	546							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						AACTGAACATCAACAGCATGC	0.483													T	64722249	T	T	64722249	2	4	239	1	0	0	0	0	0	0	0	1	17559	816	29	3		3	ZC3H12B	23	64722249	Silent	SNP	C	TCGA-32-4213-01A-01D-1353-08	7701428	64722249	90548311	87	17075											
TGIF2LX	90316	broad.mit.edu	37	chrX	89177514	89177514	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaccgaggcgtctgtgccgGccaagtcagggcccagtggt	16	13	2	0			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chrX:89177514G>A	uc004efe.2	+	2	479	c.430G>A	c.(430-432)GCC>ACC	p.A144T		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	144						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GTCTGTGCCGGCCAAGTCAGG	0.582													A	89177514	A	A	89177514	3	1	239	1	0	0	0	0	1	0	0	0	15824	1203	42	3	432	3	TGIF2LX	23	89177514	Missense_Mutation	SNP	G	TCGA-32-4213-01A-01D-1353-08	24455265	89177514	66093046	88	17076											
NRK	203447	broad.mit.edu	37	chrX	105181458	105181458	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tttgctgttgggaacccgatCtaatctatatctgatggaca	9	8	3	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chrX:105181458C>A	uc004emd.2	+	22	3986	c.3683C>A	c.(3682-3684)TCT>TAT	p.S1228Y	NRK_uc010npc.1_Missense_Mutation_p.S896Y	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1228	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GGAACCCGATCTAATCTATAT	0.353										HNSCC(51;0.14)			A	105181458	A	A	105181458	3	1	239	1	0	0	0	0	1	0	0	0	10655	913	32	5	3769	5	NRK	23	105181458	Missense_Mutation	SNP	C	TCGA-32-4213-01A-01D-1353-08	16003944	105181458	50089102	89	17077											
COL4A6	1288	broad.mit.edu	37	chrX	107404862	107404862	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcagaccttcaaatcctggAgggccttgcagtccaggcag	11	12	2	1			TCGA-32-4213-01A-01D-1353-08	TCGA-32-4213-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	540254b7-1e24-4c10-a467-544de9041f41	4555a302-112d-423b-9b1d-272557799539	g.chrX:107404862A>G	uc004enw.3	-	42	4426	c.4323T>C	c.(4321-4323)CCT>CCC	p.P1441P	COL4A6_uc004env.3_Silent_p.P1440P|COL4A6_uc011msn.1_Silent_p.P1416P|COL4A6_uc010npk.2_Silent_p.P1383P|COL4A6_uc011msm.1_5'Flank|COL4A6_uc010npj.2_Intron	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1441	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CAAATCCTGGAGGGCCTTGCA	0.607									Alport_syndrome_with_Diffuse_Leiomyomatosis				G	107404862	G	G	107404862	2	3	239	1	0	0	0	0	0	0	0	1	3695	291	11	4		4	COL4A6	23	107404862	Silent	SNP	A	TCGA-32-4213-01A-01D-1353-08	2223404	107404862	47865698	90	17078											
FUCA1	2517	broad.mit.edu	37	chr1	24186383	24186383	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cccatcagaccagatcagatCaggtttatagctggaagaca	9	10	3	4			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr1:24186383C>G	uc001bie.2	-	4	718	c.673G>C	c.(673-675)GAT>CAT	p.D225H	FUCA1_uc009vqt.1_RNA|FUCA1_uc010oed.1_RNA	NM_000147	NP_000138	P04066	FUCO_HUMAN	fucosidase, alpha-L-1, tissue precursor	225					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		CAGATCAGATCAGGTTTATAG	0.373													G	24186383	G	G	24186383	3	3	240	1	0	0	0	0	1	0	0	0	6094	826	29	5	747	5	FUCA1	1	24186383	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08		24186383	225064238	1	17079											
PODN	127435	broad.mit.edu	37	chr1	53544261	53544261	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccttccagggcctcaagcGgttgcacacggtgcacctgt	13	14	1	0	rs138913141		TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr1:53544261G>A	uc001cuv.2	+	8	1230	c.1223G>A	c.(1222-1224)CGG>CAG	p.R408Q	PODN_uc001cuw.2_Missense_Mutation_p.R389Q|PODN_uc010onr.1_Missense_Mutation_p.R389Q|PODN_uc010ons.1_Missense_Mutation_p.R266Q	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	360	LRR 12.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						GGCCTCAAGCGGTTGCACACG	0.647													A	53544261	A	A	53544261	3	1	240	1	0	0	0	0	1	0	0	0	12178	1116	39	2	1253	2	PODN	1	53544261	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	29357878	53544261	195706360	2	17080											
INADL	10207	broad.mit.edu	37	chr1	62299351	62299351	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccacaatatggatgtcaataCtgaagaagatgatgatgggg	12	5	1	5	rs112258254	byFrequency	TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr1:62299351C>G	uc001dab.2	+	17	2120	c.2006C>G	c.(2005-2007)ACT>AGT	p.T669S	INADL_uc009waf.1_Missense_Mutation_p.T669S|INADL_uc001daa.2_Missense_Mutation_p.T669S|INADL_uc001dad.3_Missense_Mutation_p.T366S|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	669					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						GATGTCAATACTGAAGAAGAT	0.363													G	62299351	G	G	62299351	3	3	240	1	0	0	0	0	1	0	0	0	7731	565	20	5	2068	5	INADL	1	62299351	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	8755090	62299351	186951270	3	17081											
TTC24	164118	broad.mit.edu	37	chr1	156554756	156554756	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggaagcagcacagcaggtGtccagcacaggtgagggtgg	17	9	0	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr1:156554756G>A	uc009wsc.1	+	5	639	c.499G>A	c.(499-501)GTC>ATC	p.V167I		NM_001105669	NP_001099139	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	447							binding			pancreas(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CACAGCAGGTGTCCAGCACAG	0.642													A	156554756	A	A	156554756	3	1	240	1	0	0	0	0	1	0	0	0	16689	1377	48	3	1361	3	TTC24	1	156554756	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	94255405	156554756	92695865	4	17082											
ETV3L	440695	broad.mit.edu	37	chr1	157068529	157068529	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cacccacgggcaccagcgctGgccgacacagggcaggggcc	15	17	0	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr1:157068529G>T	uc001fqq.1	-	3	740	c.455C>A	c.(454-456)CCA>CAA	p.P152Q		NM_001004341	NP_001004341	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	152						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Hepatocellular(266;0.158)	Prostate(1639;0.184)				CACCAGCGCTGGCCGACACAG	0.652													T	157068529	T	T	157068529	3	4	240	1	0	0	0	0	1	0	0	0	5280	1348	47	5	642	5	ETV3L	1	157068529	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	513773	157068529	92182092	5	17083											
PLEKHA6	22874	broad.mit.edu	37	chr1	204214763	204214763	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctctgtgcttggcggtgtccGtgccccgggaggggttgttc	17	11	1	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr1:204214763G>A	uc001hau.2	-	14	2329	c.2012C>T	c.(2011-2013)ACG>ATG	p.T671M	PLEKHA6_uc009xau.1_5'Flank|PLEKHA6_uc009xav.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	671										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GGCGGTGTCCGTGCCCCGGGA	0.602													A	204214763	A	A	204214763	3	1	240	1	0	0	0	0	1	0	0	0	12060	1145	40	1	1170	1	PLEKHA6	1	204214763	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	47146234	204214763	45035858	6	17084											
OR2T12	127064	broad.mit.edu	37	chr1	248458330	248458330	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtgtcagcacaagccaaaCgcaccaacacgggggcctcg	11	14	1	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr1:248458330C>T	uc010pzj.1	-	1	551	c.551G>A	c.(550-552)CGT>CAT	p.R184H		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ACAAGCCAAACGCACCAACAC	0.552													T	248458330	T	T	248458330	3	4	240	1	0	0	0	0	1	0	0	0	11019	536	19	1	414	1	OR2T12	1	248458330	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	44243567	248458330	792291	7	17085											
PTPN18	26469	broad.mit.edu	37	chr2	131128796	131128796	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgccccactctacgacgatGccctcttcctccggactccc	7	20	2	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr2:131128796G>A	uc002trc.2	+	12	1050	c.949G>A	c.(949-951)GCC>ACC	p.A317T	PTPN18_uc002trd.2_Missense_Mutation_p.A296T|PTPN18_uc002trb.2_Missense_Mutation_p.A210T|PTPN18_uc002tre.2_5'Flank	NM_014369	NP_055184	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type	317						cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			ovary(3)|kidney(1)	4	Colorectal(110;0.1)					CTACGACGATGCCCTCTTCCT	0.622													A	131128796	A	A	131128796	3	1	240	1	0	0	0	0	1	0	0	0	12784	1319	46	3	995	3	PTPN18	2	131128796	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08		131128796	112070577	8	17086											
LRP1B	53353	broad.mit.edu	37	chr2	141812781	141812781	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gagtagacagatgtgtgaacAgccccctggcattccatatg	11	10	0	3			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr2:141812781A>T	uc002tvj.1	-	10	2428	c.1456T>A	c.(1456-1458)TGT>AGT	p.C486S	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	486	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGTGTGAACAGCCCCCTGGC	0.438										TSP Lung(27;0.18)			T	141812781	T	T	141812781	3	4	240	1	0	0	0	0	1	0	0	0	8955	188	7	5	12671	5	LRP1B	2	141812781	Missense_Mutation	SNP	A	TCGA-32-4719-01A-01D-1353-08	10683985	141812781	101386592	9	17087											
TTN	7273	broad.mit.edu	37	chr2	179606204	179606204	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccactgctgattctgtttcaGtgtctttgtgaccctctcct	7	13	4	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr2:179606204G>T	uc010zfh.1	-	46	11467	c.11243C>A	c.(11242-11244)ACT>AAT	p.T3748N	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.T3681N|TTN_uc010zfj.1_Missense_Mutation_p.T3556N|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	3721							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTGTTTCAGTGTCTTTGTG	0.428													T	179606204	T	T	179606204	3	4	240	1	0	0	0	0	1	0	0	0	16732	1029	36	5	93033	5	TTN	2	179606204	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	37793423	179606204	63593169	10	17088											
FN1	2335	broad.mit.edu	37	chr2	216232682	216232682	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcgttcccactcatctccaaCggcataatgggaaactgtgt	8	12	2	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr2:216232682C>G	uc002vfa.2	-	42	7188	c.6922G>C	c.(6922-6924)GTT>CTT	p.V2308L	FN1_uc002vfb.2_Missense_Mutation_p.V2096L|FN1_uc002vfc.2_Missense_Mutation_p.V2071L|FN1_uc002vfd.2_Missense_Mutation_p.V2252L|FN1_uc002vfe.2_Missense_Mutation_p.V2186L|FN1_uc002vff.2_Missense_Mutation_p.V2161L|FN1_uc002vfg.2_Missense_Mutation_p.V2127L|FN1_uc002vfh.2_Missense_Mutation_p.V2007L|FN1_uc002vfi.2_Missense_Mutation_p.V2277L|FN1_uc002vfj.2_Missense_Mutation_p.V2098L|FN1_uc002vez.2_Missense_Mutation_p.V471L|FN1_uc010zjp.1_Missense_Mutation_p.V845L|FN1_uc002vfk.1_Intron|FN1_uc010fva.1_RNA|FN1_uc010fvb.1_RNA	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	2217	Fibronectin type-I 10.|Fibrin-binding 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCATCTCCAACGGCATAATGG	0.438													G	216232682	G	G	216232682	3	3	240	1	0	0	0	0	1	0	0	0	5962	536	19	5	531	5	FN1	2	216232682	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	36626478	216232682	26966691	11	17089											
PAX3	5077	broad.mit.edu	37	chr2	223066852	223066852	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccggtgagaggggagagcgCgtaatcagtctggggctgat	18	8	2	3			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr2:223066852C>T	uc010fwo.2	-	8	1597	c.1231G>A	c.(1231-1233)GCG>ACG	p.A411T	PAX3_uc002vmt.1_Missense_Mutation_p.A411T|PAX3_uc002vmy.1_Missense_Mutation_p.A410T|PAX3_uc002vmv.1_Missense_Mutation_p.A411T|PAX3_uc002vmw.1_Intron|PAX3_uc002vmx.1_Intron	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	411					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGAGAGCGCGTAATCAGTC	0.547			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						T	223066852	T	T	223066852	3	4	240	1	0	0	0	0	1	0	0	0	11480	768	27	1	326	1	PAX3	2	223066852	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	6834170	223066852	20132521	12	17090											
KLHL30	377007	broad.mit.edu	37	chr2	239049594	239049594	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatgtttgcgggtgacttcGccgagagcttctctgcgcgc	13	13	1	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr2:239049594G>A	uc002vxr.1	+	1	178	c.145G>A	c.(145-147)GCC>ACC	p.A49T		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	67	BTB.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GGGTGACTTCGCCGAGAGCTT	0.677													A	239049594	A	A	239049594	3	1	240	1	0	0	0	0	1	0	0	0	8384	1087	38	1	201	1	KLHL30	2	239049594	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	15982742	239049594	4149779	13	17091											
ANKRD28	23243	broad.mit.edu	37	chr3	15778600	15778600	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccctgctcgatcagatacGtttacattactcagaagagg	8	11	2	3			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr3:15778600G>A	uc003caj.1	-	5	545	c.402C>T	c.(400-402)AAC>AAT	p.N134N	ANKRD28_uc003cai.1_Translation_Start_Site|ANKRD28_uc011avz.1_Translation_Start_Site|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Silent_p.N164N|ANKRD28_uc003cam.2_Silent_p.N167N	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	134	ANK 3.					nucleoplasm	protein binding			breast(1)	1						GATCAGATACGTTTACATTAC	0.428													A	15778600	A	A	15778600	2	1	240	1	0	0	0	0	0	0	0	1	656	1136	40	1		1	ANKRD28	3	15778600	Silent	SNP	G	TCGA-32-4719-01A-01D-1353-08		15778600	182243830	14	17092											
BCL6	604	broad.mit.edu	37	chr3	187443315	187443315	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctggctccgcaggtttcgCatttgtagggcttctctcca	10	12	2	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr3:187443315C>T	uc003frp.3	-	8	2268	c.1811G>A	c.(1810-1812)TGC>TAC	p.C604Y	BCL6_uc011bsf.1_Missense_Mutation_p.C548Y|BCL6_uc010hza.2_Missense_Mutation_p.C502Y|BCL6_uc003frq.1_Missense_Mutation_p.C604Y	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	604	C2H2-type 4.				negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GCAGGTTTCGCATTTGTAGGG	0.328			T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								T	187443315	T	T	187443315	3	4	240	1	0	0	0	0	1	0	0	0	1376	710	25	3	321	3	BCL6	3	187443315	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	171664715	187443315	10579115	15	17093											
TAPT1	202018	broad.mit.edu	37	chr4	16204132	16204132	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcctgaatagtgccaggaaAactcttaaaggaagcagggt	12	7	1	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr4:16204132A>G	uc010ied.1	-	3	483	c.402T>C	c.(400-402)GTT>GTC	p.V134V	TAPT1_uc011bxe.1_Silent_p.V23V|TAPT1_uc003gow.3_Intron	NM_153365	NP_699196	Q6NXT6	TAPT1_HUMAN	transmembrane anterior posterior transformation	134						integral to membrane	growth hormone-releasing hormone receptor activity				0						GTGCCAGGAAAACTCTTAAAG	0.353													G	16204132	G	G	16204132	2	3	240	1	0	0	0	0	0	0	0	1	15551	1	1	4		4	TAPT1	4	16204132	Silent	SNP	A	TCGA-32-4719-01A-01D-1353-08		16204132	174950144	16	17094											
EGFLAM	133584	broad.mit.edu	37	chr5	38463973	38463974	+	Frame_Shift_Ins	INS	-	T	T													ctgcacactaacaggcaataINStatgagagggctcgtgggct							TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr5:38463973_38463974insT	uc003jlc.1	+	23	3263_3264	c.2939_2940insT	c.(2938-2940)TATfs	p.Y980fs	EGFLAM_uc003jlb.1_Frame_Shift_Ins_p.Y972fs|EGFLAM_uc003jle.1_Frame_Shift_Ins_p.Y738fs|EGFLAM_uc003jlf.1_Frame_Shift_Ins_p.Y338fs|EGFLAM_uc003jlg.1_Frame_Shift_Ins_p.Y115fs|EGFLAM_uc003jlh.1_Frame_Shift_Ins_p.Y62fs	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	980	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AACAGGCAATATATGAGAGGGC	0.52													T	38463974	T	T	38463973	7	5	240	1	0	1	1	0	0	0	0	0	4966	449	16	0	3015	0	EGFLAM	5	38463973	Frame_Shift_Ins	INS	-	TCGA-32-4719-01A-01D-1353-08		38463973	142451287	17	17095											
BRD8	10902	broad.mit.edu	37	chr5	137476545	137476545	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tccgacccttagagagatttCtcttcaggctagttaagtcc	8	11	2	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr5:137476545C>T	uc003lcf.1	-	26	3519	c.3464G>A	c.(3463-3465)AGA>AAA	p.R1155K	BRD8_uc003lcc.1_Intron|NME5_uc003lce.2_5'Flank	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	1155	Bromo 2.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AGAGAGATTTCTCTTCAGGCT	0.428													T	137476545	T	T	137476545	3	4	240	1	0	0	0	0	1	0	0	0	1506	913	32	3	251	3	BRD8	5	137476545	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	99012572	137476545	43438715	18	17096											
WDR46	9277	broad.mit.edu	37	chr6	33255194	33255194	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttactcggtcacagcggcGgatacagtggagctcaatgc	13	10	2	0	rs141256696	byFrequency	TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr6:33255194G>A	uc003ods.2	-	8	861	c.817C>T	c.(817-819)CGC>TGC	p.R273C	WDR46_uc011dra.1_Missense_Mutation_p.R219C|WDR46_uc010juo.1_RNA|PFDN6_uc003odt.1_5'Flank|PFDN6_uc010jup.1_5'Flank	NM_005452	NP_005443	O15213	WDR46_HUMAN	WD repeat domain 46 isoform 1	273											0						TCACAGCGGCGGATACAGTGG	0.572													A	33255194	A	A	33255194	3	1	240	1	0	0	0	0	1	0	0	0	17296	1116	39	2	1047	2	WDR46	6	33255194	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08		33255194	137859873	19	17097											
MACC1	346389	broad.mit.edu	37	chr7	20199676	20199676	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cattttctatttctctacagAaaagaaaaggatcttccttt	4	8	3	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr7:20199676A>G	uc003sus.3	-	5	617	c.308T>C	c.(307-309)TTC>TCC	p.F103S	MACC1_uc010kug.2_Missense_Mutation_p.F103S	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	103					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TTCTCTACAGAAAAGAAAAGG	0.348													G	20199676	G	G	20199676	3	3	240	1	0	0	0	0	1	0	0	0	9143	246	9	4	2262	4	MACC1	7	20199676	Missense_Mutation	SNP	A	TCGA-32-4719-01A-01D-1353-08		20199676	138938987	20	17098											
ABCB5	340273	broad.mit.edu	37	chr7	20767947	20767947	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtacattccagaaatacctcGaagaaagcacagattattgg	8	8	0	3			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr7:20767947G>A	uc003suw.3	+	14	1947	c.1401G>A	c.(1399-1401)TCG>TCA	p.S467S	ABCB5_uc010kuh.2_Silent_p.S912S|ABCB5_uc003sux.1_Silent_p.S90S	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	467	Cytoplasmic (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						GAAATACCTCGAAGAAAGCAC	0.353													A	20767947	A	A	20767947	2	1	240	1	0	0	0	0	0	0	0	1	44	1045	37	2		2	ABCB5	7	20767947	Silent	SNP	G	TCGA-32-4719-01A-01D-1353-08	568271	20767947	138370716	21	17099											
OR6V1	346517	broad.mit.edu	37	chr7	142750291	142750291	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcaccccctttctcaatcCctttatccttaccttctgca	1	18	3	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr7:142750291C>T	uc011ksv.1	+	1	854	c.854C>T	c.(853-855)CCC>CTC	p.P285L		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TTTCTCAATCCCTTTATCCTT	0.507													T	142750291	T	T	142750291	3	4	240	1	0	0	0	0	1	0	0	0	11211	623	22	3	856	3	OR6V1	7	142750291	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	121982344	142750291	16388372	22	17100											
DOCK8	81704	broad.mit.edu	37	chr9	426982	426982	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgcaggaaaacattatccagGtgaggaaaacaaacacccaa	8	9	0	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr9:426982G>T	uc003zgf.2	+	34	4450	c.4338_splice	c.e34+1	p.Q1446_splice	DOCK8_uc010mgu.2_Splice_Site_p.Q748_splice|DOCK8_uc010mgv.2_Splice_Site_p.Q1346_splice|DOCK8_uc003zgk.2_Splice_Site_p.Q904_splice	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8						blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CATTATCCAGGTGAGGAAAAC	0.383													T	426982	T	T	426982	5	4	240	1	0	0	0	0	0	0	1	0	4693	1275	44	5	4473	5	DOCK8	9	426982	Splice_Site	SNP	G	TCGA-32-4719-01A-01D-1353-08		426982	140786449	23	17101											
RGS3	5998	broad.mit.edu	37	chr9	116259676	116259677	+	Frame_Shift_Ins	INS	-	GCTGAGAG	GCTGAGAG													gccaggcggcgactgcggccINSgctgagaggtacctgcacac							TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr9:116259676_116259677insGCTGAGAG	uc004bhq.2	+	10	1042_1043	c.833_834insGCTGAGAG	c.(832-834)CCGfs	p.P278fs	RGS3_uc004bhr.2_Frame_Shift_Ins_p.P166fs|RGS3_uc004bhs.2_Frame_Shift_Ins_p.P168fs	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	278					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						CGACTGCGGCCGCTGAGAGGTA	0.619													GCTGAGAG	116259677	GCTGAGAG	GCTGAGAG	116259676	7	5	240	1	0	1	1	0	0	0	0	0	13306	652	23	0	950	0	RGS3	9	116259676	Frame_Shift_Ins	INS	-	TCGA-32-4719-01A-01D-1353-08	115832694	116259676	24953755	24	17102											
VAV2	7410	broad.mit.edu	37	chr9	136656960	136656960	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctcaaggtctccttgtccCgtttaacttcattgatgtac	6	12	3	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr9:136656960C>T	uc004ces.2	-	13	1179	c.1133G>A	c.(1132-1134)CGG>CAG	p.R378Q	VAV2_uc004cer.2_Missense_Mutation_p.R373Q|VAV2_uc004cet.1_5'Flank	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	378					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CTCCTTGTCCCGTTTAACTTC	0.488													T	136656960	T	T	136656960	3	4	240	1	0	0	0	0	1	0	0	0	17129	652	23	2	1575	2	VAV2	9	136656960	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	20397284	136656960	4556471	25	17103											
ARHGAP21	57584	broad.mit.edu	37	chr10	24873489	24873489	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actgtggtggtatggaaagaAggggcctgtttgttgaagcc	16	5	0	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr10:24873489A>C	uc001isb.2	-	26	6216	c.5729T>G	c.(5728-5730)CTT>CGT	p.L1910R	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1909					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TATGGAAAGAAGGGGCCTGTT	0.483													C	24873489	C	C	24873489	3	2	240	1	0	0	0	0	1	0	0	0	871	72	3	5	151	5	ARHGAP21	10	24873489	Missense_Mutation	SNP	A	TCGA-32-4719-01A-01D-1353-08		24873489	110661258	26	17104											
BTAF1	9044	broad.mit.edu	37	chr10	93786503	93786503	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaccgggcccatcgcattGggcaggtaaaagtcaatttt	12	9	1	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr10:93786503G>A	uc001khr.2	+	36	5328	c.5230G>A	c.(5230-5232)GGG>AGG	p.G1744R		NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1744	Helicase C-terminal.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity	p.G1744G(1)		ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				CCATCGCATTGGGCAGGTAAA	0.383													A	93786503	A	A	93786503	3	1	240	1	0	0	0	0	1	0	0	0	1536	1348	47	3	5372	3	BTAF1	10	93786503	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	68913014	93786503	41748244	27	17105											
KNDC1	85442	broad.mit.edu	37	chr10	135020727	135020727	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcaccctgcgacacgctggaCttcagccccctggacgagtc	11	17	1	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr10:135020727C>A	uc001llz.1	+	20	3667	c.3666C>A	c.(3664-3666)GAC>GAA	p.D1222E		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1222					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		ACACGCTGGACTTCAGCCCCC	0.687													A	135020727	A	A	135020727	3	1	240	1	0	0	0	0	1	0	0	0	8426	564	20	5	3744	5	KNDC1	10	135020727	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	41234224	135020727	514020	28	17106											
LRP4	4038	broad.mit.edu	37	chr11	46894746	46894746	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccatccaagtttgcccgttcGatcttggcaatgtggcccca	9	14	1	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr11:46894746G>A	uc001ndn.3	-	30	4634	c.4488C>T	c.(4486-4488)ATC>ATT	p.I1496I	uc001ndl.2_RNA	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1496	Extracellular (Potential).|LDL-receptor class B 18.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		TTGCCCGTTCGATCTTGGCAA	0.552													A	46894746	A	A	46894746	2	1	240	1	0	0	0	0	0	0	0	1	8959	1048	37	2		2	LRP4	11	46894746	Silent	SNP	G	TCGA-32-4719-01A-01D-1353-08		46894746	88111770	29	17107											
OR4A15	81328	broad.mit.edu	37	chr11	55135883	55135883	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtgttcttatgctgttggCggcctggattggaggctttc	14	8	1	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr11:55135883C>T	uc010rif.1	+	1	524	c.524C>T	c.(523-525)GCG>GTG	p.A175V		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	175	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATGCTGTTGGCGGCCTGGATT	0.443													T	55135883	T	T	55135883	3	4	240	1	0	0	0	0	1	0	0	0	11040	768	27	1	526	1	OR4A15	11	55135883	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	8241137	55135883	79870633	30	17108											
TECTA	7007	broad.mit.edu	37	chr11	121000704	121000704	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctcaagttttatcgaagcCgctccaggtgcggcatcatc	10	12	2	0	rs139132568		TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr11:121000704C>T	uc010rzo.1	+	9	2725	c.2725C>T	c.(2725-2727)CGC>TGC	p.R909C		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	909	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TTATCGAAGCCGCTCCAGGTG	0.562													T	121000704	T	T	121000704	3	4	240	1	0	0	0	0	1	0	0	0	15744	652	23	2	2759	2	TECTA	11	121000704	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	65864821	121000704	14005812	31	17109											
PIK3C2G	5288	broad.mit.edu	37	chr12	18699324	18699324	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atatgtgtataataatcttcGtccacaagacacagacctgg	7	9	1	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr12:18699324G>A	uc001rdt.2	+	25	3541	c.3425G>A	c.(3424-3426)CGT>CAT	p.R1142H	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.R1183H|PIK3C2G_uc010sic.1_Missense_Mutation_p.R961H	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1142	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				AATAATCTTCGTCCACAAGAC	0.408													A	18699324	A	A	18699324	3	1	240	1	0	0	0	0	1	0	0	0	11911	1145	40	1	3519	1	PIK3C2G	12	18699324	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08		18699324	115152571	32	17110											
KRT79	338785	broad.mit.edu	37	chr12	53218087	53218087	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tccaggtccaggttgcggttGttgtccatggacagcaccac	12	12	0	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr12:53218087G>T	uc001sbb.2	-	5	948	c.915C>A	c.(913-915)AAC>AAA	p.N305K	KRT79_uc001sba.2_Missense_Mutation_p.N76K	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	305	Rod.|Linker 12.					keratin filament	structural molecule activity	p.N305K(1)		ovary(2)|skin(2)	4						GGTTGCGGTTGTTGTCCATGG	0.597													T	53218087	T	T	53218087	3	4	240	1	0	0	0	0	1	0	0	0	8492	1368	48	5	712	5	KRT79	12	53218087	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	34518763	53218087	80633808	33	17111											
SLC16A7	9194	broad.mit.edu	37	chr12	60169207	60169207	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttccagtgccgtcggactTgtcacaattgtggagtgtgg	13	8	1	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr12:60169207T>G	uc001sqs.2	+	5	1430	c.1131T>G	c.(1129-1131)CTT>CTG	p.L377L	SLC16A7_uc001sqt.2_Silent_p.L377L|SLC16A7_uc001squ.2_Silent_p.L377L|SLC16A7_uc009zqi.2_Silent_p.L278L|SLC16A7_uc010ssi.1_Silent_p.L278L	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	377	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	CCGTCGGACTTGTCACAATTG	0.438													G	60169207	G	G	60169207	2	3	240	1	0	0	0	0	0	0	0	1	14413	1799	63	5		5	SLC16A7	12	60169207	Silent	SNP	T	TCGA-32-4719-01A-01D-1353-08	6951120	60169207	73682688	34	17112											
KCTD10	83892	broad.mit.edu	37	chr12	109889455	109889455	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatgtggatcctccgcacgCgctcgatccgctcccgctcc	10	18	0	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr12:109889455C>T	uc001toi.1	-	7	975	c.887G>A	c.(886-888)CGC>CAC	p.R296H	KCTD10_uc001toh.1_RNA|KCTD10_uc009zvi.1_Missense_Mutation_p.R270H|KCTD10_uc001toj.1_Missense_Mutation_p.R305H|KCTD10_uc001tok.1_Missense_Mutation_p.R115H	NM_031954	NP_114160	Q9H3F6	BACD3_HUMAN	potassium channel tetramerisation domain	296					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|nucleus|voltage-gated potassium channel complex	voltage-gated potassium channel activity				0						CCTCCGCACGCGCTCGATCCG	0.716													T	109889455	T	T	109889455	3	4	240	1	0	0	0	0	1	0	0	0	8097	768	27	1	58	1	KCTD10	12	109889455	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	49720248	109889455	23962440	35	17113											
OR4K5	79317	broad.mit.edu	37	chr14	20389343	20389343	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acttgcctgcctggactcttAcatcattgaaatactaattg	6	10	2	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr14:20389343A>T	uc010tkw.1	+	1	578	c.578A>T	c.(577-579)TAC>TTC	p.Y193F		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGGACTCTTACATCATTGAA	0.393													T	20389343	T	T	20389343	3	4	240	1	0	0	0	0	1	0	0	0	11073	391	14	5	580	5	OR4K5	14	20389343	Missense_Mutation	SNP	A	TCGA-32-4719-01A-01D-1353-08		20389343	86960197	36	17114											
GABRB3	2562	broad.mit.edu	37	chr15	26825472	26825472	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgcaggactcacctgtggCgaagacaacattcctcgaga	11	11	1	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr15:26825472C>T	uc001zaz.2	-	6	818	c.676G>A	c.(676-678)GCC>ACC	p.A226T	GABRB3_uc010uae.1_Missense_Mutation_p.A141T|GABRB3_uc001zba.2_Missense_Mutation_p.A226T|GABRB3_uc001zbb.2_Missense_Mutation_p.A282T	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	226	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCACCTGTGGCGAAGACAACA	0.572													T	26825472	T	T	26825472	3	4	240	1	0	0	0	0	1	0	0	0	6168	768	27	1	761	1	GABRB3	15	26825472	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08		26825472	75705920	37	17115											
GOLGA6C	653641	broad.mit.edu	37	chr15	75557692	75557692	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaacaagtccagctagagcGggacgaatatgctaaacaca	9	9	0	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr15:75557692G>A	uc002azs.1	+	9	727	c.650G>A	c.(649-651)CGG>CAG	p.R217Q	uc002azt.1_5'Flank	NM_001145224	NP_001138696	A6NDK9	GOG6C_HUMAN	golgi autoantigen, golgin subfamily a, 6D	229	Potential.									ovary(1)	1						CAGCTAGAGCGGGACGAATAT	0.542													A	75557692	A	A	75557692	3	1	240	1	0	0	0	0	1	0	0	0	6559	1116	39	2	720	2	GOLGA6C	15	75557692	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	48732220	75557692	26973700	38	17116											
HAGH	3029	broad.mit.edu	37	chr16	1867224	1867224	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagctttacacatctcatccGcagtcccttcatagaacttc	5	14	2	1	rs150713216		TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr16:1867224G>A	uc002cna.2	-	6	997	c.590C>T	c.(589-591)GCG>GTG	p.A197V	HAGH_uc002cmz.2_Missense_Mutation_p.A149V|HAGH_uc010uvp.1_Missense_Mutation_p.R161W|HAGH_uc002cnb.1_Missense_Mutation_p.A149V	NM_005326	NP_005317	Q16775	GLO2_HUMAN	hydroxyacylglutathione hydrolase isoform 1	197					glutathione biosynthetic process	cytoplasm|mitochondrial matrix|mitochondrial matrix	hydroxyacylglutathione hydrolase activity|zinc ion binding			ovary(1)	1		Hepatocellular(780;0.00335)			Glutathione(DB00143)	CATCTCATCCGCAGTCCCTTC	0.637													A	1867224	A	A	1867224	3	1	240	1	0	0	0	0	1	0	0	0	6945	1087	38	1	352	1	HAGH	16	1867224	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08		1867224	88487529	39	17117											
PDILT	204474	broad.mit.edu	37	chr16	20376785	20376785	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctttgtcaaagacgactacGttgaagttcttccccacgag	8	11	3	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr16:20376785G>A	uc002dhc.1	-	9	1417	c.1194C>T	c.(1192-1194)AAC>AAT	p.N398N		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	398	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						AGACGACTACGTTGAAGTTCT	0.448													A	20376785	A	A	20376785	2	1	240	1	0	0	0	0	0	0	0	1	11674	1136	40	1		1	PDILT	16	20376785	Silent	SNP	G	TCGA-32-4719-01A-01D-1353-08	18509561	20376785	69977968	40	17118											
IL17C	27189	broad.mit.edu	37	chr16	88705562	88705562	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaggtgccaagtgggggcaGgctttgcctgtagccctggt	17	10	0	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr16:88705562G>A	uc002fla.2	+	2	229	c.180G>A	c.(178-180)CAG>CAA	p.Q60Q		NM_013278	NP_037410	Q9P0M4	IL17C_HUMAN	interleukin 17C precursor	60					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		AGTGGGGGCAGGCTTTGCCTG	0.697													A	88705562	A	A	88705562	2	1	240	1	0	0	0	0	0	0	0	1	7636	991	35	3		3	IL17C	16	88705562	Silent	SNP	G	TCGA-32-4719-01A-01D-1353-08	68328777	88705562	1649191	41	17119											
RAPGEFL1	51195	broad.mit.edu	37	chr17	38340589	38340589	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagaggaagagggggccggCcacatcatcaaggtgggcct	16	10	2	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr17:38340589C>T	uc010cwu.1	+	3	595	c.105C>T	c.(103-105)GGC>GGT	p.G35G		NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	241					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AGGGGGCCGGCCACATCATCA	0.587													T	38340589	T	T	38340589	2	4	240	1	0	0	0	0	0	0	0	1	13049	726	26	3		3	RAPGEFL1	17	38340589	Silent	SNP	C	TCGA-32-4719-01A-01D-1353-08		38340589	42854621	42	17120											
DHX40	79665	broad.mit.edu	37	chr17	57665340	57665340	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtgcagtaataaaagctgCttccctggattgtgaagatc	10	7	0	2			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr17:57665340C>T	uc002ixn.1	+	12	1655	c.1508C>T	c.(1507-1509)GCT>GTT	p.A503V	DHX40_uc010woe.1_Missense_Mutation_p.A426V|DHX40_uc010wof.1_Missense_Mutation_p.A18V	NM_024612	NP_078888	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	503							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					ATAAAAGCTGCTTCCCTGGAT	0.398													T	57665340	T	T	57665340	3	4	240	1	0	0	0	0	1	0	0	0	4512	797	28	3	1554	3	DHX40	17	57665340	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	19324751	57665340	23529870	43	17121											
SCN4A	6329	broad.mit.edu	37	chr17	62019282	62019282	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcaggacacgcccaatccGcgccaggcggatcacacgga	12	17	1	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr17:62019282G>A	uc002jds.1	-	24	4437	c.4360C>T	c.(4360-4362)CGG>TGG	p.R1454W		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1454	Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).|IV.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	CGCCCAATCCGCGCCAGGCGG	0.642													A	62019282	A	A	62019282	3	1	240	1	0	0	0	0	1	0	0	0	13920	1086	38	1	1154	1	SCN4A	17	62019282	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	4353942	62019282	19175928	44	17122											
LAMA1	284217	broad.mit.edu	37	chr18	6982557	6982557	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggagctgcgctgcacggcCgctttcccgttagaaacaag	12	13	0	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr18:6982557C>T	uc002knm.2	-	41	5923	c.5829G>A	c.(5827-5829)GCG>GCA	p.A1943A	LAMA1_uc010wzj.1_Silent_p.A1419A	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1943	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTGCACGGCCGCTTTCCCGT	0.547													T	6982557	T	T	6982557	2	4	240	1	0	0	0	0	0	0	0	1	8605	639	23	2		2	LAMA1	18	6982557	Silent	SNP	C	TCGA-32-4719-01A-01D-1353-08		6982557	71094691	45	17123											
ATP8B3	148229	broad.mit.edu	37	chr19	1805392	1805392	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ccttgaaaggacgccatcttCtttatagtggccagttcttt	8	10	3	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr19:1805392C>A	uc002ltw.2	-	10	1119	c.885G>T	c.(883-885)AAG>AAT	p.K295N	ATP8B3_uc002ltv.2_Missense_Mutation_p.K242N|ATP8B3_uc002ltx.2_RNA|ATP8B3_uc002lty.1_Missense_Mutation_p.K43N|ATP8B3_uc002ltz.1_Missense_Mutation_p.K242N	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	295	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCCATCTTCTTTATAGTGG	0.478													A	1805392	A	A	1805392	3	1	240	1	0	0	0	0	1	0	0	0	1196	912	32	5	3145	5	ATP8B3	19	1805392	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08		1805392	57323591	46	17124											
DOT1L	84444	broad.mit.edu	37	chr19	2227030	2227030	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttcagctctgtgccggccGccgcaggcctggtgcacgtg	15	14	2	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr19:2227030G>A	uc002lvb.3	+	27	4546	c.4510G>A	c.(4510-4512)GCC>ACC	p.A1504T	DOT1L_uc002lvc.1_Missense_Mutation_p.A798T	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1504						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCCGGCCGCCGCAGGCCT	0.697													A	2227030	A	A	2227030	3	1	240	1	0	0	0	0	1	0	0	0	4709	1087	38	1	4616	1	DOT1L	19	2227030	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	421638	2227030	56901953	47	17125											
OR7G3	390883	broad.mit.edu	37	chr19	9237058	9237058	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgttattgatgaggacatcaGaacaggcgagcttgagaata	12	5	1	4			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr19:9237058G>A	uc010xkl.1	-	1	569	c.569C>T	c.(568-570)TCT>TTT	p.S190F		NM_001001958	NP_001001958	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAGGACATCAGAACAGGCGAG	0.463													A	9237058	A	A	9237058	3	1	240	1	0	0	0	0	1	0	0	0	11224	942	33	3	372	3	OR7G3	19	9237058	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	7010028	9237058	49891925	48	17126											
GPR77	27202	broad.mit.edu	37	chr19	47844107	47844107	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggattacagcgacctctcGgaccgccctgtggactgcct	13	14	1	0	rs115216760	byFrequency	TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr19:47844107G>A	uc010ela.1	+	2	269	c.51G>A	c.(49-51)TCG>TCA	p.S17S	GPR77_uc002pgk.1_Silent_p.S17S	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	17	Extracellular (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GCGACCTCTCGGACCGCCCTG	0.627													A	47844107	A	A	47844107	2	1	240	1	0	0	0	0	0	0	0	1	6709	1103	39	2		2	GPR77	19	47844107	Silent	SNP	G	TCGA-32-4719-01A-01D-1353-08	38607049	47844107	11284876	49	17127											
GFRA4	64096	broad.mit.edu	37	chr20	3640880	3640880	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggggccacccgctggcaaaGgcctgaatggcaccatctat	13	13	1	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr20:3640880G>T	uc002wio.2	-	4	744	c.744C>A	c.(742-744)GCC>GCA	p.A248A	GFRA4_uc002win.2_Silent_p.A218A	NM_145762	NP_665705	Q9GZZ7	GFRA4_HUMAN	GDNF family receptor alpha 4 isoform b	248						anchored to membrane|extracellular region|plasma membrane	receptor activity				0						CGCTGGCAAAGGCCTGAATGG	0.647													T	3640880	T	T	3640880	2	4	240	1	0	0	0	0	0	0	0	1	6350	987	35	5		5	GFRA4	20	3640880	Silent	SNP	G	TCGA-32-4719-01A-01D-1353-08		3640880	59384640	50	17128											
ERG	2078	broad.mit.edu	37	chr21	39755623	39755623	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggcgtagcgcttcccatggAccttggtcatgatgttcttg	12	10	2	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr21:39755623A>G	uc010gnw.2	-	12	1458	c.1163T>C	c.(1162-1164)GTC>GCC	p.V388A	ERG_uc002yxa.2_Missense_Mutation_p.V381A|ERG_uc011aek.1_Missense_Mutation_p.V289A|ERG_uc010gnv.2_Missense_Mutation_p.V265A|ERG_uc010gnx.2_Missense_Mutation_p.V364A|ERG_uc011ael.1_Missense_Mutation_p.V388A|ERG_uc002yxb.2_Missense_Mutation_p.V364A	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	388	ETS.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CTTCCCATGGACCTTGGTCAT	0.592													G	39755623	G	G	39755623	3	3	240	1	0	0	0	0	1	0	0	0	5222	275	10	4	301	4	ERG	21	39755623	Missense_Mutation	SNP	A	TCGA-32-4719-01A-01D-1353-08		39755623	8374272	51	17129											
PRDM15	63977	broad.mit.edu	37	chr21	43230571	43230571	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtggacaccttggtcccgCacagctggcagctctgcgcc	13	15	1	0			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr21:43230571C>T	uc002yzq.1	-	28	3800	c.3689G>A	c.(3688-3690)TGC>TAC	p.C1230Y	PRDM15_uc002yzo.2_Missense_Mutation_p.C901Y|PRDM15_uc002yzp.2_Missense_Mutation_p.C921Y|PRDM15_uc002yzr.1_Missense_Mutation_p.C921Y	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1230	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTGGTCCCGCACAGCTGGCA	0.652													T	43230571	T	T	43230571	3	4	240	1	0	0	0	0	1	0	0	0	12456	710	25	3	850	3	PRDM15	21	43230571	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08	3474948	43230571	4899324	52	17130											
CELSR1	9620	broad.mit.edu	37	chr22	46931595	46931595	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgctgtagtgaatggccgcGttctggccctggtcccggtc	14	12	1	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chr22:46931595G>A	uc003bhw.1	-	1	1473	c.1473C>T	c.(1471-1473)AAC>AAT	p.N491N		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	491	Extracellular (Potential).|Cadherin 3.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GAATGGCCGCGTTCTGGCCCT	0.632													A	46931595	A	A	46931595	2	1	240	1	0	0	0	0	0	0	0	1	3221	1136	40	1		1	CELSR1	22	46931595	Silent	SNP	G	TCGA-32-4719-01A-01D-1353-08		46931595	4372971	53	17131											
FAM47C	442444	broad.mit.edu	37	chrX	37028050	37028050	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agactggagtgtcccatctcCgcccagagcctcccaagatt	9	15	1	3	rs145081405		TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chrX:37028050C>T	uc004ddl.1	+	1	1581	c.1567C>T	c.(1567-1569)CGC>TGC	p.R523C		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	523										ovary(3)	3						GTCCCATCTCCGCCCAGAGCC	0.612													T	37028050	T	T	37028050	3	4	240	1	0	0	0	0	1	0	0	0	5571	652	23	2	1569	2	FAM47C	23	37028050	Missense_Mutation	SNP	C	TCGA-32-4719-01A-01D-1353-08		37028050	118242510	54	17132											
PCDH11X	27328	broad.mit.edu	37	chrX	91090711	91090711	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaagctagtgtacaagaccGgagatgtgccactgattcga	11	9	1	3			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chrX:91090711G>A	uc004efk.1	+	1	1053	c.208G>A	c.(208-210)GGA>AGA	p.G70R	PCDH11X_uc004efl.1_Missense_Mutation_p.G70R|PCDH11X_uc004efo.1_Missense_Mutation_p.G70R|PCDH11X_uc010nmv.1_Missense_Mutation_p.G70R|PCDH11X_uc004efm.1_Missense_Mutation_p.G70R|PCDH11X_uc004efn.1_Missense_Mutation_p.G70R|PCDH11X_uc004efh.1_Missense_Mutation_p.G70R|PCDH11X_uc004efj.1_Missense_Mutation_p.G70R	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	70	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GTACAAGACCGGAGATGTGCC	0.458													A	91090711	A	A	91090711	3	1	240	1	0	0	0	0	1	0	0	0	11508	1117	39	2	210	2	PCDH11X	23	91090711	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	54062661	91090711	64179849	55	17133											
VSIG1	340547	broad.mit.edu	37	chrX	107301373	107301373	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caccaccactgtggcctcccGagaacagctttccatccagt	7	17	0	1			TCGA-32-4719-01A-01D-1353-08	TCGA-32-4719-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	48d702ef-c24f-4784-a17b-64858c046d56	9dc64a32-a8ad-41cf-bd6f-4efb1b016ff3	g.chrX:107301373G>A	uc004eno.2	+	2	316	c.155G>A	c.(154-156)CGA>CAA	p.R52Q	VSIG1_uc011msk.1_Missense_Mutation_p.R52Q	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	52	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						GTGGCCTCCCGAGAACAGCTT	0.468													A	107301373	A	A	107301373	3	1	240	1	0	0	0	0	1	0	0	0	17219	1058	37	2	161	2	VSIG1	23	107301373	Missense_Mutation	SNP	G	TCGA-32-4719-01A-01D-1353-08	16210662	107301373	47969187	56	17134											
MIB2	142678	broad.mit.edu	37	chr1	1563429	1563429	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggacacgcccctgcactccGccatctcggcgggcactgga	12	18	1	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr1:1563429G>A	uc001agg.2	+	14	2012	c.1885G>A	c.(1885-1887)GCC>ACC	p.A629T	MIB2_uc001agh.2_Missense_Mutation_p.A615T|MIB2_uc001agi.2_Missense_Mutation_p.A625T|MIB2_uc001agj.2_Missense_Mutation_p.A470T|MIB2_uc001agk.2_Missense_Mutation_p.A564T|MIB2_uc001agl.1_Missense_Mutation_p.A585T|MIB2_uc001agm.2_Missense_Mutation_p.A506T|MIB2_uc010nyq.1_Missense_Mutation_p.A585T|MIB2_uc009vkh.2_Missense_Mutation_p.A435T|MIB2_uc001agn.2_Missense_Mutation_p.A261T|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	629	ANK 4.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCTGCACTCCGCCATCTCGGC	0.652													A	1563429	A	A	1563429	3	1	241	1	0	0	0	0	1	0	0	0	9567	1087	38	1	2110	1	MIB2	1	1563429	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08		1563429	247687192	1	17135											
RCC1	1104	broad.mit.edu	37	chr1	28858379	28858379	+	Frame_Shift_Del	DEL	C	-	-													ctaggccagggcgacgtgggCcagctggggctgggtgagaa							TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr1:28858379delC	uc001bqg.1	+	3	223	c.138delC	c.(136-138)GGCfs	p.G46fs	SNHG3-RCC1_uc001bqa.1_Frame_Shift_Del_p.G46fs|SNHG3-RCC1_uc001bqb.1_Frame_Shift_Del_p.G46fs|SNHG3-RCC1_uc001bqc.1_Frame_Shift_Del_p.G46fs|RCC1_uc001bqe.1_Frame_Shift_Del_p.G63fs|RCC1_uc001bqf.1_Frame_Shift_Del_p.G77fs	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	46	RCC1 1.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GCGACGTGGGCCAGCTGGGGC	0.607													-	28858379	-	-	28858379	7	5	241	1	0	1	0	1	0	0	0	0	13173	726	26	0	241	0	RCC1	1	28858379	Frame_Shift_Del	DEL	C	TCGA-32-5222-01A-01D-1486-08	27294950	28858379	220392242	2	17136											
BARHL2	343472	broad.mit.edu	37	chr1	91182732	91182732	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctattccaaaactcgacccGctggccccttccattgtcat	5	16	2	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr1:91182732G>A	uc001dns.2	-	1	63	c.21C>T	c.(19-21)AGC>AGT	p.S7S		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	7						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		AACTCGACCCGCTGGCCCCTT	0.562													A	91182732	A	A	91182732	2	1	241	1	0	0	0	0	0	0	0	1	1314	1078	38	1		1	BARHL2	1	91182732	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	62324353	91182732	158067889	3	17137											
FLG2	388698	broad.mit.edu	37	chr1	152325929	152325929	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccggcttggccatgagtttGttcttgtgattgtggtctgt	13	7	2	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr1:152325929G>A	uc001ezw.3	-	3	4406	c.4333C>T	c.(4333-4335)CAA>TAA	p.Q1445*	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1445							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGAGTTTGTTCTTGTGAT	0.522													A	152325929	A	A	152325929	4	1	241	1	0	0	0	0	0	1	0	0	5923	1386	48	3	2846	3	FLG2	1	152325929	Nonsense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	61143197	152325929	96924692	4	17138											
SPTA1	6708	broad.mit.edu	37	chr1	158632643	158632643	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agagcttcaaatcggcatacCaaggactcttgccttgccct	8	13	2	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr1:158632643C>G	uc001fst.1	-	17	2512	c.2313G>C	c.(2311-2313)TTG>TTC	p.L771F		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	771	Spectrin 8.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ATCGGCATACCAAGGACTCTT	0.468													G	158632643	G	G	158632643	3	3	241	1	0	0	0	0	1	0	0	0	15115	593	21	5	5090	5	SPTA1	1	158632643	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	6306714	158632643	90617978	5	17139											
ABL2	27	broad.mit.edu	37	chr1	179084044	179084044	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agttcataaaccttagggggGcatccctcaggctgttccat	10	11	2	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr1:179084044G>A	uc001gmj.3	-	9	1817	c.1530C>T	c.(1528-1530)TGC>TGT	p.C510C	ABL2_uc010pnf.1_Silent_p.C510C|ABL2_uc010png.1_Silent_p.C489C|ABL2_uc010pnh.1_Silent_p.C489C|ABL2_uc009wxe.2_Silent_p.C489C|ABL2_uc001gmg.3_Silent_p.C495C|ABL2_uc001gmi.3_Silent_p.C495C|ABL2_uc001gmh.3_Silent_p.C474C|ABL2_uc010pne.1_Silent_p.C474C	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	510	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.P476fs*7(1)		lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CCTTAGGGGGGCATCCCTCAG	0.383			T	ETV6	AML								A	179084044	A	A	179084044	2	1	241	1	0	0	0	0	0	0	0	1	93	1195	42	3		3	ABL2	1	179084044	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	20451401	179084044	70166577	6	17140											
USH2A	7399	broad.mit.edu	37	chr1	216256823	216256823	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaaatcaggtccatctttgTtataaacgaaaagaagcaat	7	6	2	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr1:216256823T>C	uc001hku.1	-	26	5660	c.5273A>G	c.(5272-5274)AAC>AGC	p.N1758S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1758	Laminin G-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCCATCTTTGTTATAAACGAA	0.303										HNSCC(13;0.011)			C	216256823	C	C	216256823	3	2	241	1	0	0	0	0	1	0	0	0	17033	1725	60	4	10523	4	USH2A	1	216256823	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	37172779	216256823	32993798	7	17141											
CEP68	23177	broad.mit.edu	37	chr2	65296813	65296813	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggcggcccctctagagccCaccagccacaggccagtgat	11	17	1	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr2:65296813C>T	uc002sdl.3	+	2	449	c.235C>T	c.(235-237)CAC>TAC	p.H79Y	CEP68_uc002sdj.2_Missense_Mutation_p.H79Y|CEP68_uc010yqb.1_Missense_Mutation_p.H79Y|CEP68_uc002sdk.3_Missense_Mutation_p.H79Y|CEP68_uc010yqc.1_Missense_Mutation_p.H79Y|CEP68_uc010yqd.1_Missense_Mutation_p.H79Y	NM_015147	NP_055962	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	79					centrosome organization	centrosome				skin(1)	1						CTCTAGAGCCCACCAGCCACA	0.637													T	65296813	T	T	65296813	3	4	241	1	0	0	0	0	1	0	0	0	3258	594	21	3	237	3	CEP68	2	65296813	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08		65296813	177902560	8	17142											
SUCLG1	8802	broad.mit.edu	37	chr2	84652596	84652596	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctgaccacaactcctgcactCtgaagggcagagatcttctc	8	14	3	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr2:84652596C>A	uc002son.2	-	8	1150	c.957G>T	c.(955-957)CAG>CAT	p.Q319H		NM_003849	NP_003840	P53597	SUCA_HUMAN	succinate-CoA ligase, GDP-forming alpha subunit	319					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)	CTCCTGCACTCTGAAGGGCAG	0.532													A	84652596	A	A	84652596	3	1	241	1	0	0	0	0	1	0	0	0	15363	912	32	5	91	5	SUCLG1	2	84652596	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	19355783	84652596	158546777	9	17143											
CD8B	926	broad.mit.edu	37	chr2	87073862	87073862	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agaaccaggacgccagccacCagcaggccaagggtgatggg	15	12	0	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr2:87073862C>G	uc002srz.2	-	4	578	c.528G>C	c.(526-528)CTG>CTC	p.L176L	RMND5A_uc002srs.3_Intron|CD8B_uc002srw.2_Silent_p.L176L|CD8B_uc002srx.2_Silent_p.L176L|CD8B_uc002sry.2_Intron|CD8B_uc010fgt.2_Intron|CD8B_uc002ssa.2_Silent_p.L176L|CD8B_uc010yto.1_Silent_p.L176L	NM_004931	NP_004922	P10966	CD8B_HUMAN	CD8b antigen isoform 5 precursor	176	Helical; (Potential).				immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			upper_aerodigestive_tract(1)|skin(1)	2						CGCCAGCCACCAGCAGGCCAA	0.532													G	87073862	G	G	87073862	2	3	241	1	0	0	0	0	0	0	0	1	3045	581	21	5		5	CD8B	2	87073862	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08	2421266	87073862	156125511	10	17144											
TBC1D8	11138	broad.mit.edu	37	chr2	101670635	101670635	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaggtacagccagccctggCggggcaccctgcccttccaa	12	16	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr2:101670635C>T	uc010fiv.2	-	4	652	c.521G>A	c.(520-522)CGC>CAC	p.R174H	TBC1D8_uc010yvw.1_Missense_Mutation_p.R189H|TBC1D8_uc002tau.3_5'UTR	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	174	GRAM 1.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CCAGCCCTGGCGGGGCACCCT	0.587													T	101670635	T	T	101670635	3	4	241	1	0	0	0	0	1	0	0	0	15622	768	27	1	2969	1	TBC1D8	2	101670635	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	14596773	101670635	141528738	11	17145											
IL1R2	7850	broad.mit.edu	37	chr2	102644815	102644815	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcagatggtctgactgtgctAtggcctcatcatcaagactt	10	10	4	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr2:102644815A>G	uc002tbm.2	+	9	1387	c.1158A>G	c.(1156-1158)CTA>CTG	p.L386L	IL1R2_uc002tbn.2_Silent_p.L386L	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	386	Cytoplasmic (Potential).				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	TGACTGTGCTATGGCCTCATC	0.448													G	102644815	G	G	102644815	2	3	241	1	0	0	0	0	0	0	0	1	7659	436	16	4		4	IL1R2	2	102644815	Silent	SNP	A	TCGA-32-5222-01A-01D-1486-08	974180	102644815	140554558	12	17146											
IL18RAP	8807	broad.mit.edu	37	chr2	103040874	103040874	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagcggtaacctggtacaaGgtaagagtgaattctctaaa	10	8	1	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr2:103040874G>A	uc002tbx.2	+	5	1063	c.579G>A	c.(577-579)AAG>AAA	p.K193K	IL18RAP_uc010fiz.2_Silent_p.K51K	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	193	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						CCTGGTACAAGGTAAGAGTGA	0.313													A	103040874	A	A	103040874	2	1	241	1	0	0	0	0	0	0	0	1	7648	1014	35	3		3	IL18RAP	2	103040874	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	396059	103040874	140158499	13	17147											
IRS1	3667	broad.mit.edu	37	chr2	227660008	227660008	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctccccaggcctcagccaCacattctcaaaggaagcaga	8	15	2	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr2:227660008C>T	uc002voh.3	-	1	3499	c.3447G>A	c.(3445-3447)GTG>GTA	p.V1149V		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	1149					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GCCTCAGCCACACATTCTCAA	0.617													T	227660008	T	T	227660008	2	4	241	1	0	0	0	0	0	0	0	1	7840	465	17	3		3	IRS1	2	227660008	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08	124619134	227660008	15539365	14	17148											
CAMK1	8536	broad.mit.edu	37	chr3	9802446	9802446	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatagaagggagggtaaccGcagagcctgggcagggagaa	17	7	1	3	rs138951531		TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr3:9802446G>A	uc003bst.2	-	8	817	c.639C>T	c.(637-639)TGC>TGT	p.C213C	OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|CAMK1_uc003bsu.2_RNA|CAMK1_uc003bss.2_5'Flank|uc003bsv.1_RNA	NM_003656	NP_003647	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	213	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|skin(1)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		GAGGGTAACCGCAGAGCCTGG	0.557													A	9802446	A	A	9802446	2	1	241	1	0	0	0	0	0	0	0	1	2596	1079	38	1		1	CAMK1	3	9802446	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08		9802446	188219984	15	17149											
ENTPD3	956	broad.mit.edu	37	chr3	40457378	40457378	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcatggagtggaaaccacGggtgccctggacttaggtgg	16	10	0	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr3:40457378G>A	uc003ckd.3	+	7	737	c.645G>A	c.(643-645)ACG>ACA	p.T215T	ENTPD3_uc010hhy.2_Silent_p.T215T|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	215	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		TGGAAACCACGGGTGCCCTGG	0.537													A	40457378	A	A	40457378	2	1	241	1	0	0	0	0	0	0	0	1	5140	1103	39	2		2	ENTPD3	3	40457378	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	30654932	40457378	157565052	16	17150											
TRAK1	22906	broad.mit.edu	37	chr3	42261046	42261046	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcaccttcaccacctgtcGcatcctgcatccttcagatg	5	17	3	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr3:42261046G>A	uc003cky.2	+	15	2240	c.2024G>A	c.(2023-2025)CGC>CAC	p.R675H	TRAK1_uc011azi.1_Missense_Mutation_p.R654H	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	675					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						ACCACCTGTCGCATCCTGCAT	0.552													A	42261046	A	A	42261046	3	1	241	1	0	0	0	0	1	0	0	0	16446	1087	38	1	2470	1	TRAK1	3	42261046	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	1803668	42261046	155761384	17	17151											
DOCK3	1795	broad.mit.edu	37	chr3	51418534	51418534	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcccccagtcaggtctggaCggcagcaactctacgctgtc	11	15	3	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr3:51418534C>T	uc011bds.1	+	53	5660	c.5637C>T	c.(5635-5637)GAC>GAT	p.D1879D		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1879						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAGGTCTGGACGGCAGCAACT	0.617													T	51418534	T	T	51418534	2	4	241	1	0	0	0	0	0	0	0	1	4688	535	19	1		1	DOCK3	3	51418534	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08	9157488	51418534	146603896	18	17152											
POLQ	10721	broad.mit.edu	37	chr3	121208947	121208947	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcttaatataagaatcactaAatattgtgttacttttgttc	5	5	1	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr3:121208947A>C	uc003eee.3	-	16	2960	c.2831T>G	c.(2830-2832)TTT>TGT	p.F944C	POLQ_uc003eed.2_Missense_Mutation_p.F116C	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	944					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AGAATCACTAAATATTGTGTT	0.289								DNA_polymerases_(catalytic_subunits)					C	121208947	C	C	121208947	3	2	241	1	0	0	0	0	1	0	0	0	12208	14	1	5	5001	5	POLQ	3	121208947	Missense_Mutation	SNP	A	TCGA-32-5222-01A-01D-1486-08	69790413	121208947	76813483	19	17153											
ARMC8	25852	broad.mit.edu	37	chr3	137964018	137964018	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaaatgatgaagacatccGgaagaaggtgagtctgggag	15	5	1	5			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr3:137964018G>A	uc003esa.1	+	13	1452	c.1085G>A	c.(1084-1086)CGG>CAG	p.R362Q	ARMC8_uc003erw.2_Missense_Mutation_p.R362Q|ARMC8_uc003erx.2_Missense_Mutation_p.R362Q|ARMC8_uc003ery.2_Missense_Mutation_p.R334Q|ARMC8_uc003erz.2_Missense_Mutation_p.R334Q|ARMC8_uc011bmf.1_Missense_Mutation_p.R345Q|ARMC8_uc011bmg.1_Missense_Mutation_p.R309Q|ARMC8_uc011bmh.1_Missense_Mutation_p.R303Q|ARMC8_uc003esb.1_Missense_Mutation_p.R334Q|ARMC8_uc003esc.1_Missense_Mutation_p.R134Q	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2	376	ARM 8.						binding				0						GAAGACATCCGGAAGAAGGTG	0.522													A	137964018	A	A	137964018	3	1	241	1	0	0	0	0	1	0	0	0	957	1116	39	2	1131	2	ARMC8	3	137964018	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	16755071	137964018	60058412	20	17154											
SERPINI1	5274	broad.mit.edu	37	chr3	167508226	167508226	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taaagagagccaatatgtgaTgaaaattgccaattccttgt	8	6	0	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr3:167508226T>C	uc003ffa.3	+	3	515	c.317T>C	c.(316-318)ATG>ACG	p.M106T	SERPINI1_uc003ffb.3_Missense_Mutation_p.M106T	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	106					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						CAATATGTGATGAAAATTGCC	0.318													C	167508226	C	C	167508226	3	2	241	1	0	0	0	0	1	0	0	0	14118	1464	51	4	323	4	SERPINI1	3	167508226	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	29544208	167508226	30514204	21	17155											
ZNF330	27309	broad.mit.edu	37	chr4	142155058	142155058	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcagaaaggattcagataCtgagtcatcagatttgttta	10	5	3	4			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr4:142155058C>T	uc003iiq.3	+	10	1098	c.878C>T	c.(877-879)ACT>ATT	p.T293I	ZNF330_uc011chl.1_Missense_Mutation_p.T233I	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	293						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					GATTCAGATACTGAGTCATCA	0.308													T	142155058	T	T	142155058	3	4	241	1	0	0	0	0	1	0	0	0	17845	565	20	3	912	3	ZNF330	4	142155058	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08		142155058	48999218	22	17156											
SPOCK3	50859	broad.mit.edu	37	chr4	167656162	167656162	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcatcttcatcattcataatAtcgtcttcatcatcctcatc	1	13	9	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr4:167656162A>G	uc003iri.1	-	12	1362	c.1221T>C	c.(1219-1221)GAT>GAC	p.D407D	SPOCK3_uc011cjp.1_Silent_p.D364D|SPOCK3_uc011cjq.1_Silent_p.D416D|SPOCK3_uc011cjr.1_Silent_p.D287D|SPOCK3_uc003irj.1_Silent_p.D404D|SPOCK3_uc011cjs.1_Silent_p.D356D|SPOCK3_uc011cjt.1_Silent_p.D315D|SPOCK3_uc011cju.1_Silent_p.D300D|SPOCK3_uc011cjv.1_Silent_p.D309D	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	407	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		cattcataatatcgtcttcat	0.07													G	167656162	G	G	167656162	2	3	241	1	0	0	0	0	0	0	0	1	15080	446	16	4		4	SPOCK3	4	167656162	Silent	SNP	A	TCGA-32-5222-01A-01D-1486-08	25501104	167656162	23498114	23	17157											
DNAH5	1767	broad.mit.edu	37	chr5	13766102	13766102	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aacctgtaagttctgtaaaaAgttccctgcagtcatcaatt	6	9	3	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr5:13766102A>T	uc003jfd.2	-	59	10126	c.10084T>A	c.(10084-10086)TTT>ATT	p.F3362I	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3362	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTCTGTAAAAAGTTCCCTGCA	0.418									Kartagener_syndrome				T	13766102	T	T	13766102	3	4	241	1	0	0	0	0	1	0	0	0	4604	72	3	5	3874	5	DNAH5	5	13766102	Missense_Mutation	SNP	A	TCGA-32-5222-01A-01D-1486-08		13766102	167149158	24	17158											
PCDHA13	56136	broad.mit.edu	37	chr5	140263516	140263516	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtgacgctgcaggtgttcGtgctggacgagaacgacaac	14	10	0	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr5:140263516G>A	uc003lif.2	+	1	1663	c.1663G>A	c.(1663-1665)GTG>ATG	p.V555M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.V555M|PCDHA13_uc003lid.2_Missense_Mutation_p.V555M	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	555	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGGTGTTCGTGCTGGACGA	0.697													A	140263516	A	A	140263516	3	1	241	1	0	0	0	0	1	0	0	0	11523	1145	40	1	1665	1	PCDHA13	5	140263516	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	126497414	140263516	40651744	25	17159											
PCDHGA8	9708	broad.mit.edu	37	chr5	140774370	140774370	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtcacgctcaccgtagccGtggctgacagcatccccgaa	10	16	2	1	rs143444747	by1000genomes	TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr5:140774370G>A	uc003lkd.1	+	1	2888	c.1990G>A	c.(1990-1992)GTG>ATG	p.V664M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.V664M	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	664	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCGTAGCCGTGGCTGACAG	0.627													A	140774370	A	A	140774370	3	1	241	1	0	0	0	0	1	0	0	0	11560	1145	40	1	1992	1	PCDHGA8	5	140774370	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	510854	140774370	40140890	26	17160											
OR10C1	442194	broad.mit.edu	37	chr6	29408448	29408448	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	catcctgggctcctacgggcGtatcctcgttaccatcttcc	8	16	1	0	rs74711365		TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr6:29408448G>T	uc011dlp.1	+	1	656	c.656G>T	c.(655-657)CGT>CTT	p.R219L	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	219	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCTACGGGCGTATCCTCGTT	0.582													T	29408448	T	T	29408448	3	4	241	1	0	0	0	0	1	0	0	0	10898	1145	40	5	658	5	OR10C1	6	29408448	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08		29408448	141706619	27	17161											
KIF6	221458	broad.mit.edu	37	chr6	39513399	39513399	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgaactttacgcatatccGcgccaacctctaatctactg	6	13	2	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr6:39513399G>A	uc003oot.2	-	11	1342	c.1247C>T	c.(1246-1248)GCG>GTG	p.A416V	KIF6_uc010jxa.1_Missense_Mutation_p.A207V|KIF6_uc011dua.1_Missense_Mutation_p.A416V|KIF6_uc010jxb.1_Missense_Mutation_p.A416V	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	416					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						ACGCATATCCGCGCCAACCTC	0.363													A	39513399	A	A	39513399	3	1	241	1	0	0	0	0	1	0	0	0	8308	1087	38	1	1249	1	KIF6	6	39513399	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	10104951	39513399	131601668	28	17162											
TMEM63B	55362	broad.mit.edu	37	chr6	44122464	44122464	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgctgcaggactcagaggtGgacggggatggggatggggc	22	6	1	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr6:44122464G>A	uc003owr.2	+	24	2407	c.2343G>A	c.(2341-2343)GTG>GTA	p.V781V	TMEM63B_uc003ows.2_Silent_p.V684V|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	781						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			ACTCAGAGGTGGACGGGGATG	0.607													A	44122464	A	A	44122464	2	1	241	1	0	0	0	0	0	0	0	1	16188	1335	47	3		3	TMEM63B	6	44122464	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	4609065	44122464	126992603	29	17163											
TDRD6	221400	broad.mit.edu	37	chr6	46656737	46656737	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaggtataccggggttccaCggggacaggggatgagaact	16	9	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr6:46656737C>T	uc003oyj.2	+	1	872	c.872C>T	c.(871-873)ACG>ATG	p.T291M	TDRD6_uc010jze.2_Missense_Mutation_p.T285M	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	291					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CGGGGTTCCACGGGGACAGGG	0.637													T	46656737	T	T	46656737	3	4	241	1	0	0	0	0	1	0	0	0	15731	536	19	1	874	1	TDRD6	6	46656737	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	2534273	46656737	124458330	30	17164											
GSTA1	2938	broad.mit.edu	37	chr6	52659006	52659006	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttttcctcaggtggacataCgggcagaaggaggatcattt	12	7	2	1	rs1051733		TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr6:52659006C>T	uc003paz.2	-	5	443	c.331G>A	c.(331-333)GTA>ATA	p.V111I		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	111	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	GGTGGACATACGGGCAGAAGG	0.393													T	52659006	T	T	52659006	3	4	241	1	0	0	0	0	1	0	0	0	6830	536	19	1	349	1	GSTA1	6	52659006	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	6002269	52659006	118456061	31	17165											
DPPA5	340168	broad.mit.edu	37	chr6	74063914	74063914	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcgggaactttcacccacGgcgggatatgtctacgtgcc	11	13	2	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr6:74063914G>A	uc003pgs.1	-	1	40	c.35C>T	c.(34-36)CCG>CTG	p.P12L		NM_001025290	NP_001020461	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	12					multicellular organismal development	cytoplasm	RNA binding				0						TTTCACCCACGGCGGGATATG	0.582													A	74063914	A	A	74063914	3	1	241	1	0	0	0	0	1	0	0	0	4737	1116	39	2	327	2	DPPA5	6	74063914	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	21404908	74063914	97051153	32	17166											
KIAA1009	22832	broad.mit.edu	37	chr6	84911454	84911454	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atgaatataaataatatttaCcattagcaagcatgccagtt	5	6	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr6:84911454C>G	uc010kbp.2	-	8	815	c.718_splice	c.e8+1	p.V240_splice	KIAA1009_uc003pkj.3_Splice_Site_p.V164_splice|KIAA1009_uc003pkk.2_Splice_Site_p.V240_splice	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein						cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		ATAATATTTACCATTAGCAAG	0.264													G	84911454	G	G	84911454	5	3	241	1	0	0	0	0	0	0	1	0	8203	521	18	5	3572	5	KIAA1009	6	84911454	Splice_Site	SNP	C	TCGA-32-5222-01A-01D-1486-08	10847540	84911454	86203613	33	17167											
RAET1G	353091	broad.mit.edu	37	chr6	150240886	150240886	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catccacctggccttgaaccGcacaccaccgtggtccaggt	9	17	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr6:150240886G>A	uc010kii.1	-	2	220	c.152C>T	c.(151-153)GCG>GTG	p.A51V	RAET1G_uc003qnm.2_RNA	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	51	MHC class I alpha-1 like.|Extracellular (Potential).				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		GCCTTGAACCGCACACCACCG	0.532													A	150240886	A	A	150240886	3	1	241	1	0	0	0	0	1	0	0	0	13000	1087	38	1	868	1	RAET1G	6	150240886	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	65329432	150240886	20874181	34	17168											
HECW1	23072	broad.mit.edu	37	chr7	43484403	43484403	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgtgtccgagctggagacGgtgatcgcgtcagcctgcgg	16	12	1	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr7:43484403G>A	uc003tid.1	+	11	2237	c.1632G>A	c.(1630-1632)ACG>ACA	p.T544T	HECW1_uc011kbi.1_Silent_p.T544T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	544					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGCTGGAGACGGTGATCGCGT	0.672													A	43484403	A	A	43484403	2	1	241	1	0	0	0	0	0	0	0	1	7042	1103	39	2		2	HECW1	7	43484403	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08		43484403	115654260	35	17169											
SEMA3C	10512	broad.mit.edu	37	chr7	80433421	80433421	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cggaacagcattaatacttaCaggacatattcgagcaatca	7	9	1	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr7:80433421C>G	uc003uhj.2	-	8	1363	c.801_splice	c.e8+1	p.P267_splice	SEMA3C_uc011kgw.1_Splice_Site_p.P285_splice|SEMA3C_uc011kgx.1_Splice_Site_p.P119_splice	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor						immune response|response to drug	membrane	receptor activity			ovary(1)	1						TTAATACTTACAGGACATATT	0.323													G	80433421	G	G	80433421	5	3	241	1	0	0	0	0	0	0	1	0	14026	492	17	5	1497	5	SEMA3C	7	80433421	Splice_Site	SNP	C	TCGA-32-5222-01A-01D-1486-08	36949018	80433421	78705242	36	17170											
PCLO	27445	broad.mit.edu	37	chr7	82585982	82585982	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttttcttttctgacttttcAtcagcaagtgtacttgcttg	7	8	4	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr7:82585982A>G	uc003uhx.2	-	5	4576	c.4287T>C	c.(4285-4287)GAT>GAC	p.D1429D	PCLO_uc003uhv.2_Silent_p.D1429D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1360					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGACTTTTCATCAGCAAGTG	0.398													G	82585982	G	G	82585982	2	3	241	1	0	0	0	0	0	0	0	1	11583	214	8	4		4	PCLO	7	82585982	Silent	SNP	A	TCGA-32-5222-01A-01D-1486-08	2152561	82585982	76552681	37	17171											
ADAM28	10863	broad.mit.edu	37	chr8	24178776	24178776	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgagatcagaaagagggtaTttgagatggctaattatgtc	12	3	1	4			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr8:24178776T>C	uc003xdy.2	+	8	777	c.694T>C	c.(694-696)TTT>CTT	p.F232L	ADAM28_uc003xdx.2_Missense_Mutation_p.F232L|ADAM28_uc011kzz.1_5'UTR|ADAM28_uc011laa.1_Intron	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	232	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AAAGAGGGTATTTGAGATGGC	0.323													C	24178776	C	C	24178776	3	2	241	1	0	0	0	0	1	0	0	0	246	1493	52	4	724	4	ADAM28	8	24178776	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08		24178776	122185246	38	17172											
ST18	9705	broad.mit.edu	37	chr8	53044717	53044717	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgatatgtgaccttggcCatcacaccctatcacaggac	7	14	2	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr8:53044717C>T	uc003xqz.2	-	17	2623	c.2467G>A	c.(2467-2469)GGC>AGC	p.G823S	ST18_uc011ldq.1_Missense_Mutation_p.G470S|ST18_uc011ldr.1_Missense_Mutation_p.G788S|ST18_uc011lds.1_Missense_Mutation_p.G728S|ST18_uc003xra.2_Missense_Mutation_p.G823S	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	823	C2HC-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGACCTTGGCCATCACACCCT	0.498													T	53044717	T	T	53044717	3	4	241	1	0	0	0	0	1	0	0	0	15211	594	21	3	696	3	ST18	8	53044717	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	28865941	53044717	93319305	39	17173											
ZNF623	9831	broad.mit.edu	37	chr8	144732707	144732707	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttttgtcacagttcagaccTgattaggcaccagagagttc	10	9	2	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr8:144732707T>C	uc003yzd.2	+	1	754	c.665T>C	c.(664-666)CTG>CCG	p.L222P	ZNF623_uc011lkp.1_Missense_Mutation_p.L182P|ZNF623_uc003yzc.2_Missense_Mutation_p.L182P	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	222	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AGTTCAGACCTGATTAGGCAC	0.478													C	144732707	C	C	144732707	3	2	241	1	0	0	0	0	1	0	0	0	18044	1580	55	4	667	4	ZNF623	8	144732707	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	91687990	144732707	1631315	40	17174											
PLEC	5339	broad.mit.edu	37	chr8	144994985	144994985	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgcacagagcgctcacctcGctgcagctgctggtagagct	12	14	1	2	rs137853161		TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr8:144994985G>A	uc003zaf.1	-	32	9585	c.9415C>T	c.(9415-9417)CGA>TGA	p.R3139*	PLEC_uc003zab.1_Nonsense_Mutation_p.R3002*|PLEC_uc003zac.1_Nonsense_Mutation_p.R3006*|PLEC_uc003zad.2_Nonsense_Mutation_p.R3002*|PLEC_uc003zae.1_Nonsense_Mutation_p.R2970*|PLEC_uc003zag.1_Nonsense_Mutation_p.R2980*|PLEC_uc003zah.2_Nonsense_Mutation_p.R2988*|PLEC_uc003zaj.2_Nonsense_Mutation_p.R3029*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3139	Plectin 6.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCTCACCTCGCTGCAGCTGC	0.687													A	144994985	A	A	144994985	4	1	241	1	0	0	0	0	0	1	0	0	12052	1095	38	1	4643	1	PLEC	8	144994985	Nonsense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	262278	144994985	1369037	41	17175											
HEMGN	55363	broad.mit.edu	37	chr9	100692686	100692686	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggctttaggcacaataatttCgttacatgttttatgaggaa	9	5	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr9:100692686C>T	uc004axy.2	-	3	1099	c.991G>A	c.(991-993)GAA>AAA	p.E331K	HEMGN_uc004axz.2_Missense_Mutation_p.E331K	NM_197978	NP_932095	Q9BXL5	HEMGN_HUMAN	hemogen	331					cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				ACAATAATTTCGTTACATGTT	0.358													T	100692686	T	T	100692686	3	4	241	1	0	0	0	0	1	0	0	0	7050	893	31	2	471	2	HEMGN	9	100692686	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08		100692686	40520745	42	17176											
OR13C3	138803	broad.mit.edu	37	chr9	107298286	107298286	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtcaggtgagctgagcacGtggaaaatgccttgcgtctt	13	9	2	2	rs145157195		TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr9:107298286G>A	uc004bcb.1	-	1	809	c.809C>T	c.(808-810)ACG>ATG	p.T270M		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	270	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						AGCTGAGCACGTGGAAAATGC	0.428													A	107298286	A	A	107298286	3	1	241	1	0	0	0	0	1	0	0	0	10935	1145	40	1	238	1	OR13C3	9	107298286	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	6605600	107298286	33915145	43	17177											
OR13C8	138802	broad.mit.edu	37	chr9	107331551	107331551	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcgttctaattttgtggatgTacctgatgatcctgcttgga	10	7	1	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr9:107331551T>C	uc011lvo.1	+	1	103	c.103T>C	c.(103-105)TAC>CAC	p.Y35H		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTTGTGGATGTACCTGATGAT	0.443													C	107331551	C	C	107331551	3	2	241	1	0	0	0	0	1	0	0	0	10938	1638	57	4	105	4	OR13C8	9	107331551	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	33265	107331551	33881880	44	17178											
PTEN	5728	broad.mit.edu	37	chr10	89692902	89692902	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcactgtaaagctggaaaggGacgaactggtgtaatgatat	12	5	1	1	rs121909218		TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr10:89692902G>A	uc001kfb.2	+	6	1417	c.386G>A	c.(385-387)GGA>GAA	p.G129E		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	129	Phosphatase tensin-type.		G -> E (in CD; no lipid phosphatase activity but retains protein phosphatase activity; retains ability to inhibit focal adhesion formation).|G -> R (in glioblastoma; severely reduced protein phosphatase activity; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.G129R(6)|p.R55fs*1(4)|p.G129*(3)|p.K128_R130del(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G129V(1)|p.K128fs*47(1)|p.A121_F145del(1)|p.G129E(1)|p.G129fs*5(1)|p.G127fs*5(1)|p.G129fs*50(1)|p.F56fs*2(1)|p.G129fs*51(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GCTGGAAAGGGACGAACTGGT	0.413		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89692902	A	A	89692902	3	1	241	1	0	0	0	0	1	0	0	0	12738	1174	41	3	404	3	PTEN	10	89692902	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08		89692902	45841845	45	17179											
UBQLN3	50613	broad.mit.edu	37	chr11	5529018	5529018	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggagaaagggaggggaaaGgaagcccagctctgcagagt	17	6	1	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr11:5529018G>A	uc001may.1	-	2	1857	c.1771C>T	c.(1771-1773)CTT>TTT	p.L591F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	591										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGAGGGGAAAGGAAGCCCAGC	0.527													A	5529018	A	A	5529018	3	1	241	1	0	0	0	0	1	0	0	0	16895	1000	35	3	200	3	UBQLN3	11	5529018	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08		5529018	129477498	46	17180											
PAMR1	25891	broad.mit.edu	37	chr11	35454046	35454046	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcaggagatgctcgtcccGggaaggacacagccgcgatg	15	12	1	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr11:35454046G>A	uc001mwg.2	-	11	2064	c.2021C>T	c.(2020-2022)CCG>CTG	p.P674L	PAMR1_uc001mwf.2_Missense_Mutation_p.P691L|PAMR1_uc010rew.1_Missense_Mutation_p.P563L|PAMR1_uc010rex.1_Missense_Mutation_p.P634L	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	674	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						TGCTCGTCCCGGGAAGGACAC	0.567													A	35454046	A	A	35454046	3	1	241	1	0	0	0	0	1	0	0	0	11413	1116	39	2	145	2	PAMR1	11	35454046	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	29925028	35454046	99552470	47	17181											
ALX4	60529	broad.mit.edu	37	chr11	44331575	44331575	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcgtccatggcagcggccGgcgactcgcagtaagagacg	16	12	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr11:44331575G>A	uc001myb.2	-	1	142	c.38C>T	c.(37-39)CCG>CTG	p.P13L		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	13					hair follicle development						0						GGCAGCGGCCGGCGACTCGCA	0.682													A	44331575	A	A	44331575	3	1	241	1	0	0	0	0	1	0	0	0	558	1116	39	2	1213	2	ALX4	11	44331575	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	8877529	44331575	90674941	48	17182											
SLC22A11	55867	broad.mit.edu	37	chr11	64335161	64335161	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccaggccctcttcggggcCgtggacttcctgggccgggc	15	16	1	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr11:64335161C>T	uc001oai.2	+	7	1523	c.1149C>T	c.(1147-1149)GCC>GCT	p.A383A	SLC22A11_uc001oaj.2_Silent_p.A383A|SLC22A11_uc009ypq.2_Intron	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	383	Helical; (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	TCTTCGGGGCCGTGGACTTCC	0.642													T	64335161	T	T	64335161	2	4	241	1	0	0	0	0	0	0	0	1	14442	639	23	2		2	SLC22A11	11	64335161	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08	20003586	64335161	70671355	49	17183											
PIH1D2	120379	broad.mit.edu	37	chr11	111943820	111943820	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaacttctcatagccctcagGgtcactctgagctagatcat	7	12	5	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr11:111943820G>A	uc001pmq.3	-	2	161	c.79C>T	c.(79-81)CCT>TCT	p.P27S	PIH1D2_uc009yyl.2_Missense_Mutation_p.P27S|PIH1D2_uc001pmp.3_Missense_Mutation_p.P27S|PIH1D2_uc010rws.1_Missense_Mutation_p.P27S|C11orf57_uc001pmu.2_5'Flank|C11orf57_uc001pmw.3_5'Flank|C11orf57_uc001pmt.3_5'Flank|C11orf57_uc001pmr.3_5'Flank|C11orf57_uc001pmv.3_5'Flank|C11orf57_uc001pms.3_5'Flank	NM_138789	NP_620144	Q8WWB5	PIHD2_HUMAN	PIH1 domain containing 2 isoform 1	27										ovary(1)	1		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		TAGCCCTCAGGGTCACTCTGA	0.463													A	111943820	A	A	111943820	3	1	241	1	0	0	0	0	1	0	0	0	11907	1232	43	3	946	3	PIH1D2	11	111943820	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	47608659	111943820	23062696	50	17184											
ST14	6768	broad.mit.edu	37	chr11	130064098	130064098	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accttccactcctcccagaaCgtcctgctcatcacactgat	4	18	2	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr11:130064098C>A	uc001qfw.2	+	8	1123	c.930C>A	c.(928-930)AAC>AAA	p.N310K	ST14_uc010sca.1_Missense_Mutation_p.N120K	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	310	Extracellular (Potential).|CUB 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	CCTCCCAGAACGTCCTGCTCA	0.587													A	130064098	A	A	130064098	3	1	241	1	0	0	0	0	1	0	0	0	15210	535	19	5	960	5	ST14	11	130064098	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	18120278	130064098	4942418	51	17185											
C3AR1	719	broad.mit.edu	37	chr12	8212173	8212173	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctatcattcatttctccaggCggctgaacaatgttttcaag	7	10	4	1	rs138822577		TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr12:8212173C>T	uc001qtv.1	-	2	701	c.609G>A	c.(607-609)CCG>CCA	p.P203P		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	203	Extracellular (Potential).			P -> R (in Ref. 1; AAC50374).	blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		TTTCTCCAGGCGGCTGAACAA	0.408													T	8212173	T	T	8212173	2	4	241	1	0	0	0	0	0	0	0	1	2205	755	27	1		1	C3AR1	12	8212173	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08		8212173	125639722	52	17186											
KRT8	3856	broad.mit.edu	37	chr12	53292563	53292563	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtactcacgcagctgccgcgCcatgtcctgcttggcccgct	11	17	1	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr12:53292563C>T	uc001sbd.2	-	6	1205	c.1102G>A	c.(1102-1104)GCG>ACG	p.A368T	KRT8_uc009zmj.2_Intron|KRT8_uc009zmk.1_Missense_Mutation_p.A396T|KRT8_uc009zml.1_Missense_Mutation_p.A368T|KRT8_uc009zmm.1_Missense_Mutation_p.A368T	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	368	Necessary for interaction with PNN.|Rod.|Coil 2.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCTGCCGCGCCATGTCCTGC	0.637													T	53292563	T	T	53292563	3	4	241	1	0	0	0	0	1	0	0	0	8493	739	26	3	361	3	KRT8	12	53292563	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	45080390	53292563	80559332	53	17187											
RPS26	6231	broad.mit.edu	37	chr12	56436346	56436346	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attcgaaacatagtggaggcCgcagcagtcagggacatttc	12	9	1	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr12:56436346C>T	uc001sjf.2	+	2	406	c.141C>T	c.(139-141)GCC>GCT	p.A47A		NM_001029	NP_001020	P62854	RS26_HUMAN	ribosomal protein S26	47					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|protein binding|structural constituent of ribosome			breast(1)	1			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TAGTGGAGGCCGCAGCAGTCA	0.557													T	56436346	T	T	56436346	2	4	241	1	0	0	0	0	0	0	0	1	13637	639	23	2		2	RPS26	12	56436346	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08	3143783	56436346	77415549	54	17188											
TSPAN8	7103	broad.mit.edu	37	chr12	71523126	71523126	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtacctcaataactgccagTccaaatgatattccaataac	4	11	1	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr12:71523126T>C	uc009zrt.1	-	7	807	c.645A>G	c.(643-645)GGA>GGG	p.G215G	TSPAN8_uc001swk.1_Silent_p.G215G|TSPAN8_uc001swj.1_Silent_p.G215G	NM_004616	NP_004607	P19075	TSN8_HUMAN	transmembrane 4 superfamily member 3	215	Helical; (Potential).				protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			TAACTGCCAGTCCAAATGATA	0.274													C	71523126	C	C	71523126	2	2	241	1	0	0	0	0	0	0	0	1	16650	1654	58	4		4	TSPAN8	12	71523126	Silent	SNP	T	TCGA-32-5222-01A-01D-1486-08	15086780	71523126	62328769	55	17189											
CCDC63	160762	broad.mit.edu	37	chr12	111336859	111336859	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcaagaagataaactgtgaCgccaccaagatcctggtgca	9	10	1	4	rs115748204	by1000genomes	TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr12:111336859C>T	uc001trv.1	+	10	1467	c.1272C>T	c.(1270-1272)GAC>GAT	p.D424D	CCDC63_uc010sye.1_Silent_p.D384D|CCDC63_uc001trw.1_Silent_p.D339D	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	424										skin(6)|ovary(1)|pancreas(1)	8						TAAACTGTGACGCCACCAAGA	0.498													T	111336859	T	T	111336859	2	4	241	1	0	0	0	0	0	0	0	1	2834	535	19	1		1	CCDC63	12	111336859	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08	39813733	111336859	22515036	56	17190											
USP12	219333	broad.mit.edu	37	chr13	27664021	27664021	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cataaagctctaaaattaccGtttgtgtgcttcctgtttgc	7	9	1	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr13:27664021G>A	uc001uqy.2	-	6	986	c.733C>T	c.(733-735)CGG>TGG	p.R245W		NM_182488	NP_872294	O75317	UBP12_HUMAN	ubiquitin thiolesterase 12	245					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		TAAAATTACCGTTTGTGTGCT	0.353													A	27664021	A	A	27664021	3	1	241	1	0	0	0	0	1	0	0	0	17040	1159	40	1	395	1	USP12	13	27664021	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08		27664021	87505857	57	17191											
SOHLH2	54937	broad.mit.edu	37	chr13	36748890	36748890	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggctggagagattttctccCggatatatttcacataatca	8	9	3	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr13:36748890C>T	uc001uvj.2	-	7	847	c.758G>A	c.(757-759)CGG>CAG	p.R253Q	SOHLH2_uc010tei.1_Missense_Mutation_p.R330Q	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	253	Helix-loop-helix motif.				cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		GATTTTCTCCCGGATATATTT	0.403													T	36748890	T	T	36748890	3	4	241	1	0	0	0	0	1	0	0	0	14924	652	23	2	539	2	SOHLH2	13	36748890	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	9084869	36748890	78420988	58	17192											
RCBTB2	1102	broad.mit.edu	37	chr13	49070369	49070369	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gccgagagcagagcgatggcAttctcctcgcagatgccttg	13	12	1	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr13:49070369A>T	uc001vch.2	-	14	1844	c.1473T>A	c.(1471-1473)AAT>AAA	p.N491K	RCBTB2_uc010tgg.1_Missense_Mutation_p.N496K|RCBTB2_uc001vci.2_Missense_Mutation_p.N467K|RCBTB2_uc010tgh.1_Missense_Mutation_p.N217K|RCBTB2_uc001vcj.2_Missense_Mutation_p.N443K	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	491	BTB 2.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		GAGCGATGGCATTCTCCTCGC	0.502													T	49070369	T	T	49070369	3	4	241	1	0	0	0	0	1	0	0	0	13172	214	8	5	190	5	RCBTB2	13	49070369	Missense_Mutation	SNP	A	TCGA-32-5222-01A-01D-1486-08	12321479	49070369	66099509	59	17193											
PCDH17	27253	broad.mit.edu	37	chr13	58207833	58207833	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgggactctggcaagaacGgacagctgcagtgtcgggtc	15	11	1	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr13:58207833G>A	uc001vhq.1	+	1	2045	c.1153G>A	c.(1153-1155)GGA>AGA	p.G385R	PCDH17_uc010aec.1_Missense_Mutation_p.G385R	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	385	Extracellular (Potential).|Gly-rich.|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGGCAAGAACGGACAGCTGCA	0.557													A	58207833	A	A	58207833	3	1	241	1	0	0	0	0	1	0	0	0	11512	1117	39	2	1155	2	PCDH17	13	58207833	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	9137464	58207833	56962045	60	17194											
PCDH17	27253	broad.mit.edu	37	chr13	58208729	58208729	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccaagctcatcatccgctcGgtgagcggatcccttcccga	10	16	2	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr13:58208729G>A	uc001vhq.1	+	1	2941	c.2049G>A	c.(2047-2049)TCG>TCA	p.S683S	PCDH17_uc010aec.1_Silent_p.S683S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	683	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCATCCGCTCGGTGAGCGGAT	0.632													A	58208729	A	A	58208729	2	1	241	1	0	0	0	0	0	0	0	1	11512	1103	39	2		2	PCDH17	13	58208729	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	896	58208729	56961149	61	17195											
AHNAK2	113146	broad.mit.edu	37	chr14	105418199	105418199	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcatggaggggagactcaCgtcggcctccactttgggtg	15	11	1	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr14:105418199C>T	uc010axc.1	-	7	3709	c.3589G>A	c.(3589-3591)GTG>ATG	p.V1197M	AHNAK2_uc001ypx.2_Missense_Mutation_p.V1097M	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1197						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGAGACTCACGTCGGCCTCC	0.617													T	105418199	T	T	105418199	3	4	241	1	0	0	0	0	1	0	0	0	415	536	19	1	13802	1	AHNAK2	14	105418199	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08		105418199	1931341	62	17196											
MAP1A	4130	broad.mit.edu	37	chr15	43818898	43818898	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgagcaagaagtacccctgCgggaacacgcaacccggagc	12	13	0	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr15:43818898C>T	uc001zrt.2	+	4	5694	c.5227C>T	c.(5227-5229)CGG>TGG	p.R1743W		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1743						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGTACCCCTGCGGGAACACGC	0.597													T	43818898	T	T	43818898	3	4	241	1	0	0	0	0	1	0	0	0	9227	759	27	1	5229	1	MAP1A	15	43818898	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08		43818898	58712494	63	17197											
BNC1	646	broad.mit.edu	37	chr15	83935703	83935703	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtccagtaggatttttaggCgaacggggatggcctgggtc	17	7	0	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr15:83935703C>T	uc002bjt.1	-	3	408	c.320G>A	c.(319-321)CGC>CAC	p.R107H	BNC1_uc010uos.1_Missense_Mutation_p.R95H	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	107					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R107C(1)		ovary(3)	3						GATTTTTAGGCGAACGGGGAT	0.507													T	83935703	T	T	83935703	3	4	241	1	0	0	0	0	1	0	0	0	1474	768	27	1	2676	1	BNC1	15	83935703	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	40116805	83935703	18595689	64	17198											
PCSK6	5046	broad.mit.edu	37	chr15	101929721	101929721	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caccatgggggcagagactgAggtcccagtgtggccatcgg	16	11	0	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr15:101929721A>G	uc002bwy.2	-	10	1572	c.1258T>C	c.(1258-1260)TCA>CCA	p.S420P	PCSK6_uc010bpd.2_Missense_Mutation_p.S290P|PCSK6_uc010bpe.2_Missense_Mutation_p.S420P|PCSK6_uc002bxa.2_Missense_Mutation_p.S420P|PCSK6_uc002bxb.2_Missense_Mutation_p.S420P|PCSK6_uc002bxc.1_Missense_Mutation_p.S420P|PCSK6_uc002bxd.1_Missense_Mutation_p.S420P|PCSK6_uc002bxe.2_Missense_Mutation_p.S420P|PCSK6_uc002bxg.1_Missense_Mutation_p.S420P	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	420	Catalytic.	Charge relay system (By similarity).			glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GCAGAGACTGAGGTCCCAGTG	0.507													G	101929721	G	G	101929721	3	3	241	1	0	0	0	0	1	0	0	0	11604	304	11	4	2186	4	PCSK6	15	101929721	Missense_Mutation	SNP	A	TCGA-32-5222-01A-01D-1486-08	17994018	101929721	601671	65	17199											
TBL3	10607	broad.mit.edu	37	chr16	2025082	2025082	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcactggccttcagcgccgaCggccacaccatgctcaggtc	10	17	3	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr16:2025082C>T	uc002cnu.1	+	7	720	c.618C>T	c.(616-618)GAC>GAT	p.D206D	TBL3_uc002cnv.1_Silent_p.D92D|TBL3_uc010bsb.1_Missense_Mutation_p.R21W|TBL3_uc010bsc.1_Silent_p.D92D|TBL3_uc010uvt.1_Translation_Start_Site|TBL3_uc002cnw.1_5'Flank	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	206	WD 4.				G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0						TCAGCGCCGACGGCCACACCA	0.652													T	2025082	T	T	2025082	2	4	241	1	0	0	0	0	0	0	0	1	15640	535	19	1		1	TBL3	16	2025082	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08		2025082	88329671	66	17200											
CCDC113	29070	broad.mit.edu	37	chr16	58287944	58287944	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatcccggacaggtatggacCgtggggtaggcctgactgcc	15	11	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr16:58287944C>T	uc002ene.2	+	3	350	c.271C>T	c.(271-273)CGT>TGT	p.R91C	CCDC113_uc010vid.1_Intron	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	91						protein complex					0						AGGTATGGACCGTGGGGTAGG	0.507													T	58287944	T	T	58287944	3	4	241	1	0	0	0	0	1	0	0	0	2750	652	23	2	281	2	CCDC113	16	58287944	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	56262862	58287944	32066809	67	17201											
FLCN	201163	broad.mit.edu	37	chr17	17119805	17119805	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgatgcggacgcagcccaCgggaagcatggtctgaggag	17	9	1	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr17:17119805C>T	uc002gra.3	-	11	1693	c.1189G>A	c.(1189-1191)GTG>ATG	p.V397M	PLD6_uc010cpn.2_RNA	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	397					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						ACGCAGCCCACGGGAAGCATG	0.637									Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				T	17119805	T	T	17119805	3	4	241	1	0	0	0	0	1	0	0	0	5921	536	19	1	566	1	FLCN	17	17119805	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08		17119805	64075405	68	17202											
KRT37	8688	broad.mit.edu	37	chr17	39578590	39578590	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catggcctcgtactgagcccGcatctcccccaacaccctgt	7	19	1	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr17:39578590G>A	uc002hwp.1	-	4	876	c.829C>T	c.(829-831)CGG>TGG	p.R277W	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	277	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				TACTGAGCCCGCATCTCCCCC	0.582													A	39578590	A	A	39578590	3	1	241	1	0	0	0	0	1	0	0	0	8474	1086	38	1	536	1	KRT37	17	39578590	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	22458785	39578590	41616620	69	17203											
G6PC	2538	broad.mit.edu	37	chr17	41063121	41063121	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtgcgagcagccagaatgggTccacattgacaccacaccct	10	14	0	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr17:41063121T>C	uc002icb.1	+	5	831	c.752T>C	c.(751-753)GTC>GCC	p.V251A	G6PC_uc010whf.1_3'UTR	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	251	Lumenal (Potential).				gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CCAGAATGGGTCCACATTGAC	0.582									Glycogen_Storage_Disease_type_Ia				C	41063121	C	C	41063121	3	2	241	1	0	0	0	0	1	0	0	0	6143	1667	58	4	770	4	G6PC	17	41063121	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	1484531	41063121	40132089	70	17204											
C17orf57	124989	broad.mit.edu	37	chr17	45471419	45471419	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaagtgaattttaaagaattCattgatactatgatgagcaa	7	3	1	5			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr17:45471419C>T	uc002iln.2	+	16	2166	c.1755C>T	c.(1753-1755)TTC>TTT	p.F585F	C17orf57_uc002ilm.2_Silent_p.F489F	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	585							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						TTAAAGAATTCATTGATACTA	0.259													T	45471419	T	T	45471419	2	4	241	1	0	0	0	0	0	0	0	1	1865	825	29	3		3	C17orf57	17	45471419	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08	4408298	45471419	35723791	71	17205											
GPR142	350383	broad.mit.edu	37	chr17	72368116	72368116	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccatcctgctcacggttgacCgctacactgccctgtgccac	8	18	1	1	rs149042051	byFrequency	TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr17:72368116C>T	uc010wqy.1	+	4	766	c.766C>T	c.(766-768)CGC>TGC	p.R256C	GPR142_uc010wqx.1_Missense_Mutation_p.R168C	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	256	Cytoplasmic (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CACGGTTGACCGCTACACTGC	0.687													T	72368116	T	T	72368116	3	4	241	1	0	0	0	0	1	0	0	0	6650	652	23	2	780	2	GPR142	17	72368116	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	26896697	72368116	8827094	72	17206											
CDH7	1005	broad.mit.edu	37	chr18	63547824	63547824	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgagacaccaagacccggagGgatgtgactccagaaattca	11	11	1	4			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr18:63547824G>A	uc002ljz.2	+	12	2377	c.2052G>A	c.(2050-2052)AGG>AGA	p.R684R	CDH7_uc002lkb.2_Silent_p.R684R	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	684	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				AGACCCGGAGGGATGTGACTC	0.473													A	63547824	A	A	63547824	2	1	241	1	0	0	0	0	0	0	0	1	3115	1223	43	3		3	CDH7	18	63547824	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08		63547824	14529424	73	17207											
MED16	10025	broad.mit.edu	37	chr19	868170	868170	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagagtggtgtgtggactgCgggcccagctggacaaaggc	19	8	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:868170C>T	uc002lqd.1	-	16	2716	c.2565G>A	c.(2563-2565)CCG>CCA	p.P855P	MED16_uc010drw.1_3'UTR|MED16_uc002lqe.2_3'UTR|MED16_uc002lqf.2_3'UTR	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	855					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGTGGACTGCGGGCCCAGCT	0.677													T	868170	T	T	868170	2	4	241	1	0	0	0	0	0	0	0	1	9434	755	27	1		1	MED16	19	868170	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08		868170	58260813	74	17208											
CCDC124	115098	broad.mit.edu	37	chr19	18054397	18054397	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttgaggaagcccagctgcCgcggctcaaacaagagaacc	11	13	1	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:18054397C>T	uc010xpz.1	+	5	590	c.545C>T	c.(544-546)CCG>CTG	p.P182L	CCDC124_uc002nhs.2_Missense_Mutation_p.P182L	NM_001136203	NP_001129675	Q96CT7	CC124_HUMAN	coiled-coil domain containing 124	182							DNA binding				0						GCCCAGCTGCCGCGGCTCAAA	0.637													T	18054397	T	T	18054397	3	4	241	1	0	0	0	0	1	0	0	0	2760	652	23	2	559	2	CCDC124	19	18054397	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	17186227	18054397	41074586	75	17209											
UPF1	5976	broad.mit.edu	37	chr19	18961017	18961017	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcctcggcttcatcccgGccaaagctgactcagtggtg	10	15	2	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:18961017G>A	uc002nkg.2	+	4	870	c.595G>A	c.(595-597)GCC>ACC	p.A199T	UPF1_uc002nkf.2_Missense_Mutation_p.A199T	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	199	Sufficient for interaction with RENT2.|C4-type.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CTTCATCCCGGCCAAAGCTGA	0.612													A	18961017	A	A	18961017	3	1	241	1	0	0	0	0	1	0	0	0	17000	1203	42	3	609	3	UPF1	19	18961017	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	906620	18961017	40167966	76	17210											
PRODH2	58510	broad.mit.edu	37	chr19	36303168	36303168	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgaggttcccctcataccaCgcctcactgcccagccagca	7	20	2	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:36303168C>T	uc002obx.1	-	4	624	c.606G>A	c.(604-606)GCG>GCA	p.A202A		NM_021232	NP_067055	Q9UF12	PROD2_HUMAN	kidney and liver proline oxidase 1	202					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			ovary(2)	2	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTCATACCACGCCTCACTGC	0.672													T	36303168	T	T	36303168	2	4	241	1	0	0	0	0	0	0	0	1	12549	523	19	1		1	PRODH2	19	36303168	Silent	SNP	C	TCGA-32-5222-01A-01D-1486-08	17342151	36303168	22825815	77	17211											
RYR1	6261	broad.mit.edu	37	chr19	38991601	38991601	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggacgtggggttcctgcccGacatgagggcagccgcctcg	16	13	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:38991601G>A	uc002oit.2	+	47	7715	c.7585G>A	c.(7585-7587)GAC>AAC	p.D2529N	RYR1_uc002oiu.2_Missense_Mutation_p.D2529N|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2529	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTTCCTGCCCGACATGAGGGC	0.642													A	38991601	A	A	38991601	3	1	241	1	0	0	0	0	1	0	0	0	13768	1058	37	2	7771	2	RYR1	19	38991601	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	2688433	38991601	20137382	78	17212											
FCGBP	8857	broad.mit.edu	37	chr19	40384053	40384053	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccgcgtcgcactggcagcccTccacacaggggccctcacat	10	19	1	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:40384053T>C	uc002omp.3	-	21	9565	c.9557A>G	c.(9556-9558)GAG>GGG	p.E3186G		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	3186	TIL 7.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTGGCAGCCCTCCACACAGGG	0.652													C	40384053	C	C	40384053	3	2	241	1	0	0	0	0	1	0	0	0	5778	1551	54	4	6724	4	FCGBP	19	40384053	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	1392452	40384053	18744930	79	17213											
CNTD2	79935	broad.mit.edu	37	chr19	40730663	40730663	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagtctaccaccagggcgCgcatctccggggtcacagcg	13	16	3	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:40730663C>T	uc010xvi.1	-	2	372	c.323G>A	c.(322-324)CGC>CAC	p.R108H	CNTD2_uc002ond.2_Intron	NM_024877	NP_079153	Q9H8S5	CNTD2_HUMAN	cyclin N-terminal domain containing 2 isoform 2	108					regulation of cyclin-dependent protein kinase activity		protein kinase binding				0						CACCAGGGCGCGCATCTCCGG	0.682													T	40730663	T	T	40730663	3	4	241	1	0	0	0	0	1	0	0	0	3636	768	27	1	616	1	CNTD2	19	40730663	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	346610	40730663	18398320	80	17214											
LYPD4	147719	broad.mit.edu	37	chr19	42342041	42342041	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttaaggtggaactgtaacacGtagaagcagccaaggggcaa	13	7	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:42342041G>A	uc002orp.1	-	4	1490	c.506C>T	c.(505-507)ACG>ATG	p.T169M	LYPD4_uc002orq.1_Missense_Mutation_p.T134M	NM_173506	NP_775777	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4 precursor	169	UPAR/Ly6.					anchored to membrane|plasma membrane				ovary(1)	1						ACTGTAACACGTAGAAGCAGC	0.403													A	42342041	A	A	42342041	3	1	241	1	0	0	0	0	1	0	0	0	9112	1145	40	1	242	1	LYPD4	19	42342041	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	1611378	42342041	16786942	81	17215											
PHLDB3	653583	broad.mit.edu	37	chr19	44008217	44008217	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggctggacctccacgtcgcaTtccgggaccagcggcggcgg	16	15	0	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:44008217T>G	uc002own.3	-	2	313	c.54A>C	c.(52-54)GAA>GAC	p.E18D	PHLDB3_uc002owo.2_Missense_Mutation_p.E18D	NM_198850	NP_942147	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B,	18											0		Prostate(69;0.0153)				CCACGTCGCATTCCGGGACCA	0.736													G	44008217	G	G	44008217	3	3	241	1	0	0	0	0	1	0	0	0	11853	1490	52	5	1928	5	PHLDB3	19	44008217	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	1666176	44008217	15120766	82	17216											
KLK15	55554	broad.mit.edu	37	chr19	51330300	51330300	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcgcagcaacatgatgtcGttgcggtggctgcgcgcttc	15	11	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:51330300G>A	uc002ptl.2	-	3	346	c.315C>T	c.(313-315)AAC>AAT	p.N105N	KLK15_uc002ptm.2_Silent_p.N105N|KLK15_uc002ptn.2_Silent_p.N105N|KLK15_uc002pto.2_Silent_p.N104N|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_Silent_p.N104N|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	105	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		ACATGATGTCGTTGCGGTGGC	0.687													A	51330300	A	A	51330300	2	1	241	1	0	0	0	0	0	0	0	1	8403	1136	40	1		1	KLK15	19	51330300	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	7322083	51330300	7798683	83	17217											
SIGLEC6	946	broad.mit.edu	37	chr19	52034114	52034114	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaggagaagatggggggcGtcccctgctcacagacccag	14	13	1	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:52034114G>A	uc002pwy.2	-	3	689	c.527C>T	c.(526-528)ACG>ATG	p.T176M	SIGLEC6_uc002pwz.2_Missense_Mutation_p.T176M|SIGLEC6_uc002pxa.2_Missense_Mutation_p.T176M|SIGLEC6_uc010ydb.1_Missense_Mutation_p.T129M|SIGLEC6_uc010ydc.1_Missense_Mutation_p.T165M|SIGLEC6_uc010eoz.1_Missense_Mutation_p.T154M|SIGLEC6_uc010epb.1_Missense_Mutation_p.T129M|SIGLEC6_uc010epa.1_Missense_Mutation_p.T165M	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	176	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GATGGGGGGCGTCCCCTGCTC	0.667													A	52034114	A	A	52034114	3	1	241	1	0	0	0	0	1	0	0	0	14312	1145	40	1	891	1	SIGLEC6	19	52034114	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	703814	52034114	7094869	84	17218											
LILRB1	10859	broad.mit.edu	37	chr19	55143056	55143056	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggagacccaggagtaccGtctatatagagaaaagaaaa	10	8	1	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr19:55143056G>A	uc002qgj.2	+	5	516	c.176G>A	c.(175-177)CGT>CAT	p.R59H	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.R59H|LILRB1_uc002qgk.2_Missense_Mutation_p.R59H|LILRB1_uc002qgm.2_Missense_Mutation_p.R59H|LILRB1_uc010erq.2_Missense_Mutation_p.R59H|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	59	Ig-like C2-type 1.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CAGGAGTACCGTCTATATAGA	0.572										HNSCC(37;0.09)			A	55143056	A	A	55143056	3	1	241	1	0	0	0	0	1	0	0	0	8790	1145	40	1	186	1	LILRB1	19	55143056	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	3108942	55143056	3985927	85	17219											
C20orf94	128710	broad.mit.edu	37	chr20	10603963	10603963	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cggcttagccacaaacactgAaagattatctacaattcaga	6	10	2	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr20:10603963A>G	uc010zre.1	+	8	1343	c.1163A>G	c.(1162-1164)GAA>GGA	p.E388G		NM_001009608	NP_001009608	Q5VYV7	CT094_HUMAN	hypothetical protein LOC128710	388							protein binding				0						ACAAACACTGAAAGATTATCT	0.428													G	10603963	G	G	10603963	3	3	241	1	0	0	0	0	1	0	0	0	2121	246	9	4	1189	4	C20orf94	20	10603963	Missense_Mutation	SNP	A	TCGA-32-5222-01A-01D-1486-08		10603963	52421557	86	17220											
PYGB	5834	broad.mit.edu	37	chr20	25255279	25255279	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaacccctgggagaaagcgCggcctgagtatatgcttccc	12	13	0	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr20:25255279C>T	uc002wup.2	+	5	689	c.580C>T	c.(580-582)CGG>TGG	p.R194W		NM_002862	NP_002853	P11216	PYGB_HUMAN	brain glycogen phosphorylase	194					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					Pyridoxal Phosphate(DB00114)	GGAGAAAGCGCGGCCTGAGTA	0.622													T	25255279	T	T	25255279	3	4	241	1	0	0	0	0	1	0	0	0	12860	759	27	1	598	1	PYGB	20	25255279	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	14651316	25255279	37770241	87	17221											
TGM2	7052	broad.mit.edu	37	chr20	36760804	36760804	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agccagcaggtagctgttgaTaactggctccacgaggaggg	15	9	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr20:36760804T>A	uc002xhr.2	-	11	1814	c.1714A>T	c.(1714-1716)ATC>TTC	p.I572F	TGM2_uc002xhq.2_Missense_Mutation_p.I173F|TGM2_uc010zvx.1_Missense_Mutation_p.I491F|TGM2_uc010zvy.1_Missense_Mutation_p.I512F|TGM2_uc002xhs.1_Missense_Mutation_p.I548F	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	572					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	TAGCTGTTGATAACTGGCTCC	0.567													A	36760804	A	A	36760804	3	1	241	1	0	0	0	0	1	0	0	0	15827	1406	49	5	361	5	TGM2	20	36760804	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	11505525	36760804	26264716	88	17222											
ARFGEF2	10564	broad.mit.edu	37	chr20	47585807	47585807	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cccttggtgaaggccctccaGacccaaagtaagcagacagc	10	14	0	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr20:47585807G>A	uc002xtx.3	+	9	1335	c.1183G>A	c.(1183-1185)GAC>AAC	p.D395N		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	395					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AGGCCCTCCAGACCCAAAGTA	0.527													A	47585807	A	A	47585807	3	1	241	1	0	0	0	0	1	0	0	0	853	942	33	3	1217	3	ARFGEF2	20	47585807	Missense_Mutation	SNP	G	TCGA-32-5222-01A-01D-1486-08	10825003	47585807	15439713	89	17223											
ARFGEF2	10564	broad.mit.edu	37	chr20	47591341	47591341	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaggcctggagtgcctcgtGtccattctcaagtgcatggt	12	10	1	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr20:47591341G>A	uc002xtx.3	+	13	1856	c.1704G>A	c.(1702-1704)GTG>GTA	p.V568V		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	568					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AGTGCCTCGTGTCCATTCTCA	0.517													A	47591341	A	A	47591341	2	1	241	1	0	0	0	0	0	0	0	1	853	1364	48	3		3	ARFGEF2	20	47591341	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	5534	47591341	15434179	90	17224											
ZFP64	55734	broad.mit.edu	37	chr20	50769893	50769893	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcttctcccccgagtgcaCccgcatgtgccttttcaagt	9	15	2	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr20:50769893C>T	uc002xwl.2	-	6	1187	c.838G>A	c.(838-840)GTG>ATG	p.V280M	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Missense_Mutation_p.V278M|ZFP64_uc002xwn.2_Missense_Mutation_p.V226M	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	280	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CCCGAGTGCACCCGCATGTGC	0.552													T	50769893	T	T	50769893	3	4	241	1	0	0	0	0	1	0	0	0	17649	507	18	3	2402	3	ZFP64	20	50769893	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	3178552	50769893	12255627	91	17225											
SLC17A9	63910	broad.mit.edu	37	chr20	61596500	61596500	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtaggttacagagccatcacGgtgcggaagctcatgcaggt	14	9	2	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr20:61596500G>A	uc002yea.3	+	9	1111	c.927G>A	c.(925-927)ACG>ACA	p.T309T	SLC17A9_uc002ydz.3_Silent_p.T303T|SLC17A9_uc011aap.1_Silent_p.T329T	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	309					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						GAGCCATCACGGTGCGGAAGC	0.587													A	61596500	A	A	61596500	2	1	241	1	0	0	0	0	0	0	0	1	14424	1103	39	2		2	SLC17A9	20	61596500	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	10826607	61596500	1429020	92	17226											
ZNF280A	129025	broad.mit.edu	37	chr22	22868791	22868791	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acgtagggcatttcgccaggCttatgatggtccttcatgtg	12	9	1	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr22:22868791C>A	uc002zwe.2	-	2	1417	c.1164G>T	c.(1162-1164)AAG>AAT	p.K388N	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TTTCGCCAGGCTTATGATGGT	0.458													A	22868791	A	A	22868791	3	1	241	1	0	0	0	0	1	0	0	0	17811	796	28	5	468	5	ZNF280A	22	22868791	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08		22868791	28435775	93	17227											
SAPS2	9701	broad.mit.edu	37	chr22	50860803	50860803	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccagctcctgctcaacccGcccaaggtaaatggccgtgg	10	16	1	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chr22:50860803G>A	uc003blb.1	+	10	1388	c.966G>A	c.(964-966)CCG>CCA	p.P322P	SAPS2_uc003bky.1_Silent_p.P322P|SAPS2_uc003bkz.1_Silent_p.P322P|SAPS2_uc003blc.2_Silent_p.P322P|SAPS2_uc003bla.1_Silent_p.P323P|uc011arw.1_5'Flank	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	322						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		TGCTCAACCCGCCCAAGGTAA	0.582													A	50860803	A	A	50860803	2	1	241	1	0	0	0	0	0	0	0	1	13837	1074	38	1		1	SAPS2	22	50860803	Silent	SNP	G	TCGA-32-5222-01A-01D-1486-08	27992012	50860803	443763	94	17228											
FAM48B1	100130302	broad.mit.edu	37	chrX	24381779	24381779	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcagaccctgtgatttggCcgtgccttcagaagtggatg	14	9	1	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chrX:24381779C>T	uc011mjx.1	+	1	902	c.902C>T	c.(901-903)GCC>GTC	p.A301V		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						TGTGATTTGGCCGTGCCTTCA	0.512													T	24381779	T	T	24381779	3	4	241	1	0	0	0	0	1	0	0	0	5573	739	26	3	904	3	FAM48B1	23	24381779	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08		24381779	130888781	95	17229											
DMD	1756	broad.mit.edu	37	chrX	32380981	32380981	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggggctctactaatttcCtgcagtggtcaccgcggttt	11	10	2	0			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chrX:32380981C>T	uc004dda.1	-	37	5493	c.5249G>A	c.(5248-5250)AGG>AAG	p.R1750K	DMD_uc004dcw.2_Missense_Mutation_p.R406K|DMD_uc004dcx.2_Missense_Mutation_p.R409K|DMD_uc004dcz.2_Missense_Mutation_p.R1627K|DMD_uc004dcy.1_Missense_Mutation_p.R1746K|DMD_uc004ddb.1_Missense_Mutation_p.R1742K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1750	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TACTAATTTCCTGCAGTGGTC	0.468													T	32380981	T	T	32380981	3	4	241	1	0	0	0	0	1	0	0	0	4580	681	24	3	6128	3	DMD	23	32380981	Missense_Mutation	SNP	C	TCGA-32-5222-01A-01D-1486-08	7999202	32380981	122889579	96	17230											
PCDH19	57526	broad.mit.edu	37	chrX	99661954	99661954	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaggatgatgacccgcaccgTagcgttgctttgcagtgagg	15	9	0	3			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chrX:99661954T>C	uc010nmz.2	-	1	3318	c.1642A>G	c.(1642-1644)ACG>GCG	p.T548A	PCDH19_uc004efw.3_Missense_Mutation_p.T548A|PCDH19_uc004efx.3_Missense_Mutation_p.T548A	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	548	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						ACCCGCACCGTAGCGTTGCTT	0.587													C	99661954	C	C	99661954	3	2	241	1	0	0	0	0	1	0	0	0	11514	1638	57	4	1828	4	PCDH19	23	99661954	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	67280973	99661954	55608606	97	17231											
STAG2	10735	broad.mit.edu	37	chrX	123202507	123202507	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atactactgttaaggaacagGttagtaattactatagatgg	9	4	0	1			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chrX:123202507G>T	uc004etz.3	+	23	2697	c.2358_splice	c.e23+1	p.Q786_splice	STAG2_uc004eua.2_Splice_Site_p.Q786_splice|STAG2_uc004eub.2_Splice_Site_p.Q786_splice|STAG2_uc004euc.2_Splice_Site_p.Q786_splice|STAG2_uc004eud.2_Splice_Site_p.Q786_splice|STAG2_uc004eue.2_Splice_Site_p.Q786_splice	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b						cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TAAGGAACAGGTTAGTAATTA	0.313													T	123202507	T	T	123202507	5	4	241	1	0	0	0	0	0	0	1	0	15242	1275	44	5	2445	5	STAG2	23	123202507	Splice_Site	SNP	G	TCGA-32-5222-01A-01D-1486-08	23540553	123202507	32068053	98	17232											
GABRA3	2556	broad.mit.edu	37	chrX	151533006	151533006	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caggaaaagaatcccaaggcTggtcatgtaacagtgacttg	11	8	1	2			TCGA-32-5222-01A-01D-1486-08	TCGA-32-5222-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	f48abf4d-f1fb-48bf-97a1-0c38435b6af7	fd30b963-9361-4b8d-a80a-37958b0a40d5	g.chrX:151533006T>C	uc010ntk.1	-	2	277	c.37A>G	c.(37-39)AGC>GGC	p.S13G		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	13					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATCCCAAGGCTGGTCATGTAA	0.423													C	151533006	C	C	151533006	3	2	241	1	0	0	0	0	1	0	0	0	6162	1580	55	4	1477	4	GABRA3	23	151533006	Missense_Mutation	SNP	T	TCGA-32-5222-01A-01D-1486-08	28330499	151533006	3737554	99	17233											
KIAA0090	23065	broad.mit.edu	37	chr1	19565777	19565777	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtcttctccccagtggtgGcaaagctcactagggcagtc	11	14	3	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr1:19565777G>A	uc001bbo.2	-	9	1017	c.974C>T	c.(973-975)GCC>GTC	p.A325V	KIAA0090_uc001bbp.2_Missense_Mutation_p.A325V|KIAA0090_uc001bbq.2_Missense_Mutation_p.A325V|KIAA0090_uc001bbr.2_Missense_Mutation_p.A303V	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	325	Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		CCCAGTGGTGGCAAAGCTCAC	0.542													A	19565777	A	A	19565777	3	1	242	1	0	0	0	0	1	0	0	0	8153	1203	42	3	2067	3	KIAA0090	1	19565777	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08		19565777	229684844	1	17234											
PLA2G2F	64600	broad.mit.edu	37	chr1	20470022	20470022	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagcgccatcctgtccttcGtgggctacggttgctactgt	13	12	0	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr1:20470022G>A	uc009vpp.1	+	3	351	c.253G>A	c.(253-255)GTG>ATG	p.V85M		NM_022819	NP_073730	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	42					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		CCTGTCCTTCGTGGGCTACGG	0.637													A	20470022	A	A	20470022	3	1	242	1	0	0	0	0	1	0	0	0	11999	1145	40	1	263	1	PLA2G2F	1	20470022	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	904245	20470022	228780599	2	17235											
SPTA1	6708	broad.mit.edu	37	chr1	158626392	158626392	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	attccgcagagctttcatacTgtctccaaatgaattgagat	7	9	2	3			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr1:158626392T>A	uc001fst.1	-	20	3059	c.2860A>T	c.(2860-2862)AGT>TGT	p.S954C		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	954	Spectrin 10.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCTTTCATACTGTCTCCAAAT	0.408													A	158626392	A	A	158626392	3	1	242	1	0	0	0	0	1	0	0	0	15115	1580	55	5	4531	5	SPTA1	1	158626392	Missense_Mutation	SNP	T	TCGA-41-2571-01A-01D-1495-08	138156370	158626392	90624229	3	17236											
LY9	4063	broad.mit.edu	37	chr1	160793477	160793477	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaggagggcgctggacatgAcccagcccctgagggccaag	15	13	1	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr1:160793477A>G	uc001fwu.2	+	8	1771	c.1721A>G	c.(1720-1722)GAC>GGC	p.D574G	LY9_uc001fwv.2_Missense_Mutation_p.D560G|LY9_uc001fww.2_Missense_Mutation_p.D484G|LY9_uc001fwx.2_Missense_Mutation_p.D484G|LY9_uc001fwy.1_Missense_Mutation_p.D372G|LY9_uc001fwz.2_Missense_Mutation_p.D212G	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	574	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GCTGGACATGACCCAGCCCCT	0.537													G	160793477	G	G	160793477	3	3	242	1	0	0	0	0	1	0	0	0	9101	275	10	4	1883	4	LY9	1	160793477	Missense_Mutation	SNP	A	TCGA-41-2571-01A-01D-1495-08	2167085	160793477	88457144	4	17237											
CEP350	9857	broad.mit.edu	37	chr1	179972355	179972355	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaacacctgatgggaaagtGtggcaggaggctgagtttca	15	7	1	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr1:179972355G>A	uc001gnt.2	+	7	1448	c.1065G>A	c.(1063-1065)GTG>GTA	p.V355V	CEP350_uc009wxl.2_Silent_p.V354V|CEP350_uc001gnu.2_Silent_p.V189V	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	355						centrosome|nucleus|spindle				ovary(4)	4						ATGGGAAAGTGTGGCAGGAGG	0.373													A	179972355	A	A	179972355	2	1	242	1	0	0	0	0	0	0	0	1	3254	1364	48	3		3	CEP350	1	179972355	Silent	SNP	G	TCGA-41-2571-01A-01D-1495-08	19178878	179972355	69278266	5	17238											
SRBD1	55133	broad.mit.edu	37	chr2	45773870	45773870	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agatatatgtaatagccttaCcagtaaacaacatccagtgg	7	8	0	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr2:45773870C>A	uc002rus.2	-	14	1950	c.1874_splice	c.e14+1	p.C625_splice	SRBD1_uc010yoc.1_Splice_Site_p.C144_splice	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AATAGCCTTACCAGTAAACAA	0.378													A	45773870	A	A	45773870	5	1	242	1	0	0	0	0	0	0	1	0	15132	521	18	5	1144	5	SRBD1	2	45773870	Splice_Site	SNP	C	TCGA-41-2571-01A-01D-1495-08		45773870	197425503	6	17239											
CRYGD	1421	broad.mit.edu	37	chr2	208986472	208986472	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cagtcctggtagcgcctataGtcccctggcatcagcaggta	11	13	1	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr2:208986472G>C	uc002vcn.3	-	3	566	c.450C>G	c.(448-450)GAC>GAG	p.D150E		NM_006891	NP_008822	P07320	CRGD_HUMAN	crystallin, gamma D	150	Beta/gamma crystallin 'Greek key' 4.				cellular response to reactive oxygen species|visual perception	soluble fraction	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		AGCGCCTATAGTCCCCTGGCA	0.542													C	208986472	C	C	208986472	3	2	242	1	0	0	0	0	1	0	0	0	3917	1020	36	5	78	5	CRYGD	2	208986472	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	163212602	208986472	34212901	7	17240											
CCR4	1233	broad.mit.edu	37	chr3	32995888	32995888	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cttcaaaacctgcaggggccTttttgtgctctgccaatact	8	12	2	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr3:32995888T>A	uc003cfg.1	+	2	1142	c.974T>A	c.(973-975)CTT>CAT	p.L325H		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	325	Cytoplasmic (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						TGCAGGGGCCTTTTTGTGCTC	0.478													A	32995888	A	A	32995888	3	1	242	1	0	0	0	0	1	0	0	0	2943	1609	56	5	976	5	CCR4	3	32995888	Missense_Mutation	SNP	T	TCGA-41-2571-01A-01D-1495-08		32995888	165026542	8	17241											
DCP1A	55802	broad.mit.edu	37	chr3	53376299	53376299	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	catggtaaggggaagctgacCttagatttaatagaagaaaa	11	4	0	4			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr3:53376299C>A	uc003dgs.3	-	3	270	c.177_splice	c.e3-1	p.R59_splice	DCP1A_uc003dgt.3_Splice_Site	NM_018403	NP_060873	Q9NPI6	DCP1A_HUMAN	DCP1 decapping enzyme homolog A						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		GGAAGCTGACCTTAGATTTAA	0.294													A	53376299	A	A	53376299	5	1	242	1	0	0	0	0	0	0	1	0	4298	695	24	5	1604	5	DCP1A	3	53376299	Splice_Site	SNP	C	TCGA-41-2571-01A-01D-1495-08	20380411	53376299	144646131	9	17242											
CD96	10225	broad.mit.edu	37	chr3	111356983	111356983	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtccccacaactgccaatgGatctacgaaaactaatcacg	6	13	2	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr3:111356983G>A	uc003dxw.2	+	13	1663	c.1493G>A	c.(1492-1494)GGA>GAA	p.G498E	CD96_uc003dxx.2_Missense_Mutation_p.G482E|CD96_uc010hpy.1_Missense_Mutation_p.G481E	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	498	Extracellular (Potential).|Pro/Ser/Thr-rich.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						ACTGCCAATGGATCTACGAAA	0.348									Opitz_Trigonocephaly_syndrome				A	111356983	A	A	111356983	3	1	242	1	0	0	0	0	1	0	0	0	3048	1174	41	3	1543	3	CD96	3	111356983	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	57980684	111356983	86665447	10	17243											
HPS3	84343	broad.mit.edu	37	chr3	148857895	148857895	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actctcgtgtgtgtatccgaAtgattgggcataatgtggag	13	6	1	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr3:148857895A>C	uc003ewu.1	+	2	462	c.322A>C	c.(322-324)ATG>CTG	p.M108L	HPS3_uc003ewt.1_Missense_Mutation_p.M108L|HPS3_uc011bnq.1_Intron	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	108						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GTGTATCCGAATGATTGGGCA	0.423									Hermansky-Pudlak_syndrome				C	148857895	C	C	148857895	3	2	242	1	0	0	0	0	1	0	0	0	7340	101	4	5	328	5	HPS3	3	148857895	Missense_Mutation	SNP	A	TCGA-41-2571-01A-01D-1495-08	37500912	148857895	49164535	11	17244											
CPN2	1370	broad.mit.edu	37	chr3	194062087	194062087	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggaagcccaagtggtcccGggtgacgggacacaccagct	14	13	0	1	rs142681810		TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr3:194062087G>A	uc003fts.2	-	2	1435	c.1345C>T	c.(1345-1347)CGG>TGG	p.R449W		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	449					protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		AAGTGGTCCCGGGTGACGGGA	0.647													A	194062087	A	A	194062087	3	1	242	1	0	0	0	0	1	0	0	0	3810	1115	39	2	296	2	CPN2	3	194062087	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	45204192	194062087	3960343	12	17245											
TLR1	7096	broad.mit.edu	37	chr4	38798601	38798601	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggccctgcgccgggtctGggtccactggcacaccatcc	12	18	1	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr4:38798601G>A	uc003gtl.2	-	4	2126	c.1852C>T	c.(1852-1854)CAG>TAG	p.Q618*		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	618	Cytoplasmic (Potential).				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						CGCCGGGTCTGGGTCCACTGG	0.522													A	38798601	A	A	38798601	4	1	242	1	0	0	0	0	0	1	0	0	15946	1357	47	3	512	3	TLR1	4	38798601	Nonsense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08		38798601	152355675	13	17246											
CCDC158	339965	broad.mit.edu	37	chr4	77288529	77288529	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttgcatagctccagcagttCgtccatgctggcccaccagc	9	16	0	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr4:77288529C>T	uc003hkb.3	-	11	1901	c.1748G>A	c.(1747-1749)CGA>CAA	p.R583Q		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	583	Potential.									skin(3)|ovary(2)|pancreas(1)	6						TCCAGCAGTTCGTCCATGCTG	0.458													T	77288529	T	T	77288529	3	4	242	1	0	0	0	0	1	0	0	0	2790	884	31	2	1649	2	CCDC158	4	77288529	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	38489928	77288529	113865747	14	17247											
PPA2	27068	broad.mit.edu	37	chr4	106317427	106317427	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatttatagctcctccattaCacttcttcataagcaatgct	3	11	2	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr4:106317427C>T	uc003hxl.2	-	9	868	c.848G>A	c.(847-849)TGT>TAT	p.C283Y	PPA2_uc003hxm.2_Missense_Mutation_p.C265Y|PPA2_uc003hxn.2_Missense_Mutation_p.C254Y|PPA2_uc003hxo.2_Missense_Mutation_p.C181Y|PPA2_uc003hxp.2_Missense_Mutation_p.C117Y|PPA2_uc003hxq.2_Missense_Mutation_p.C190Y|PPA2_uc003hxr.2_Missense_Mutation_p.C190Y	NM_176869	NP_789845	Q9H2U2	IPYR2_HUMAN	inorganic pyrophosphatase 2 isoform 1 precursor	283					diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			pancreas(1)	1		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)		TCCTCCATTACACTTCTTCAT	0.294													T	106317427	T	T	106317427	3	4	242	1	0	0	0	0	1	0	0	0	12287	478	17	3	172	3	PPA2	4	106317427	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	29028898	106317427	84836849	15	17248											
FNIP1	96459	broad.mit.edu	37	chr5	131039794	131039794	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttaatttgttcatgtggctTtcaaagagaggaaaatgtga	10	3	2	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr5:131039794T>C	uc003kvs.1	-	10	1222	c.1080A>G	c.(1078-1080)GAA>GAG	p.E360E	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Silent_p.E332E|FNIP1_uc010jdm.1_Silent_p.E315E|FNIP1_uc003kvu.2_Silent_p.E360E	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	360					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TCATGTGGCTTTCAAAGAGAG	0.269													C	131039794	C	C	131039794	2	2	242	1	0	0	0	0	0	0	0	1	5975	1838	64	4		4	FNIP1	5	131039794	Silent	SNP	T	TCGA-41-2571-01A-01D-1495-08		131039794	49875466	16	17249											
PCDHGA7	56108	broad.mit.edu	37	chr5	140763059	140763059	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccggaactggtgctggagcGggtgctggaccgggaggaag	20	9	0	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr5:140763059G>A	uc003lka.1	+	1	593	c.593G>A	c.(592-594)CGG>CAG	p.R198Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.R198Q	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	198	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCTGGAGCGGGTGCTGGAC	0.622													A	140763059	A	A	140763059	3	1	242	1	0	0	0	0	1	0	0	0	11559	1116	39	2	595	2	PCDHGA7	5	140763059	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	9723265	140763059	40152201	17	17250											
HLA-E	3133	broad.mit.edu	37	chr6	30458930	30458930	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagagcccccaaagacacaCgtgactcaccaccccatctc	5	19	3	3			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr6:30458930C>T	uc003nqg.2	+	4	665	c.627C>T	c.(625-627)CAC>CAT	p.H209H	HLA-E_uc011dmg.1_RNA|HLA-E_uc011dmh.1_Silent_p.H250H	NM_005516	NP_005507	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	209	Ig-like C1-type.|Alpha-3.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(4)|ovary(1)	5						CAAAGACACACGTGACTCACC	0.582													T	30458930	T	T	30458930	2	4	242	1	0	0	0	0	0	0	0	1	7210	535	19	1		1	HLA-E	6	30458930	Silent	SNP	C	TCGA-41-2571-01A-01D-1495-08		30458930	140656137	18	17251											
DST	667	broad.mit.edu	37	chr6	56357035	56357035	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gggttattacctgcttggctCtcttccttgcatcatccaaa	7	12	2	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr6:56357035C>G	uc003pdf.2	-	79	14418	c.14390G>C	c.(14389-14391)AGA>ACA	p.R4797T	DST_uc003pcz.3_Missense_Mutation_p.R4619T|DST_uc011dxj.1_Missense_Mutation_p.R4648T|DST_uc011dxk.1_Missense_Mutation_p.R4659T|DST_uc003pcy.3_Missense_Mutation_p.R4293T|DST_uc003pda.3_5'UTR	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6705	Spectrin 18.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTGCTTGGCTCTCTTCCTTGC	0.373													G	56357035	G	G	56357035	3	3	242	1	0	0	0	0	1	0	0	0	4783	913	32	5	2713	5	DST	6	56357035	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	25898105	56357035	114758032	19	17252											
COL19A1	1310	broad.mit.edu	37	chr6	70878104	70878104	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tacccagggccacccggtccTcctgtaagtacagttgttta	9	13	0	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr6:70878104T>A	uc003pfc.1	+	39	2655	c.2538T>A	c.(2536-2538)CCT>CCA	p.P846P		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	846	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						CACCCGGTCCTCCTGTAAGTA	0.328													A	70878104	A	A	70878104	2	1	242	1	0	0	0	0	0	0	0	1	3676	1538	54	5		5	COL19A1	6	70878104	Silent	SNP	T	TCGA-41-2571-01A-01D-1495-08	14521069	70878104	100236963	20	17253											
C6orf182	285753	broad.mit.edu	37	chr6	109481832	109481832	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaagtcattcagtctgtgaCgacatagaatgtgaactaga	10	6	3	4			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr6:109481832C>T	uc010kdk.2	+	12	1651	c.1074C>T	c.(1072-1074)GAC>GAT	p.D358D	C6orf182_uc003psx.3_Silent_p.D358D|C6orf182_uc010kdl.2_Silent_p.D358D|C6orf182_uc003psy.3_Silent_p.D358D	NM_001083535	NP_001077004	Q8IYX8	CE57L_HUMAN	hypothetical protein LOC285753	358	Potential.					microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)		CAGTCTGTGACGACATAGAAT	0.343													T	109481832	T	T	109481832	2	4	242	1	0	0	0	0	0	0	0	1	2346	535	19	1		1	C6orf182	6	109481832	Silent	SNP	C	TCGA-41-2571-01A-01D-1495-08	38603728	109481832	61633235	21	17254											
TBP	6908	broad.mit.edu	37	chr6	170878836	170878836	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agtttcctataaggttagaaGgccttgtgctcacccaccaa	8	11	1	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr6:170878836G>T	uc003qxt.2	+	6	1046	c.814G>T	c.(814-816)GGC>TGC	p.G272C	TBP_uc003qxu.2_Missense_Mutation_p.G272C|TBP_uc011ehf.1_Missense_Mutation_p.G252C	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	272	2.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		AAGGTTAGAAGGCCTTGTGCT	0.368													T	170878836	T	T	170878836	3	4	242	1	0	0	0	0	1	0	0	0	15641	1000	35	5	832	5	TBP	6	170878836	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	61397004	170878836	236231	22	17255											
C7orf65	401335	broad.mit.edu	37	chr7	47698751	47698751	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggtttcactgacccctggaaGgatgctcaggcctggatact	12	11	2	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr7:47698751G>T	uc010kyp.1	+	3	416	c.381G>T	c.(379-381)AAG>AAT	p.K127N		NM_001123065	NP_001116537	Q6ZTY9	CG065_HUMAN	hypothetical protein LOC401335	127											0						ACCCCTGGAAGGATGCTCAGG	0.552													T	47698751	T	T	47698751	3	4	242	1	0	0	0	0	1	0	0	0	2411	991	35	5	391	5	C7orf65	7	47698751	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08		47698751	111439912	23	17256											
PPP1R3A	5506	broad.mit.edu	37	chr7	113558904	113558904	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtatccaggtatatgtcttCagaagaatcagaacctcgtc	9	9	3	3			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr7:113558904C>T	uc010ljy.1	-	1	179	c.148G>A	c.(148-150)GAA>AAA	p.E50K		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	50					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TATATGTCTTCAGAAGAATCA	0.388													T	113558904	T	T	113558904	3	4	242	1	0	0	0	0	1	0	0	0	12371	835	29	3	3236	3	PPP1R3A	7	113558904	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	65860153	113558904	45579759	24	17257											
ANKRD7	56311	broad.mit.edu	37	chr7	117864828	117864828	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcagaggggcagggcggaCggctaggagttcaagaaaca	19	7	1	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr7:117864828C>T	uc003vji.2	+	1	117	c.-56C>T	c.(-58--54)GACGG>GATGG			NM_019644	NP_062618	Q92527	ANKR7_HUMAN	ankyrin repeat domain 7						male gonad development						0						GCAGGGCGGACGGCTAGGAGT	0.602													T	117864828	T	T	117864828	1	4	242	1	0	0	0	0	0	0	0	0	686	551	19	1		1	ANKRD7	7	117864828	Translation_Start_Site	SNP	C	TCGA-41-2571-01A-01D-1495-08	4305924	117864828	41273835	25	17258											
TBXAS1	6916	broad.mit.edu	37	chr7	139655361	139655361	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctttgtgaaacactgcaagCgtttcttcgaattctgcatc	7	11	2	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr7:139655361C>T	uc011kqv.1	+	8	948	c.784C>T	c.(784-786)CGT>TGT	p.R262C	TBXAS1_uc003vvh.2_Missense_Mutation_p.R216C|TBXAS1_uc010lne.2_Missense_Mutation_p.R148C|TBXAS1_uc011kqu.1_Missense_Mutation_p.R167C|TBXAS1_uc003vvi.2_Missense_Mutation_p.R216C|TBXAS1_uc003vvj.2_Missense_Mutation_p.R216C|TBXAS1_uc011kqw.1_Missense_Mutation_p.R196C	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	215	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					ACACTGCAAGCGTTTCTTCGA	0.577													T	139655361	T	T	139655361	3	4	242	1	0	0	0	0	1	0	0	0	15661	768	27	1	814	1	TBXAS1	7	139655361	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	21790533	139655361	19483302	26	17259											
TACC1	6867	broad.mit.edu	37	chr8	38677275	38677275	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtcctcggaacaaaagcagcTcatggctgtgtaactgcagt	11	10	1	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr8:38677275T>C	uc010lwp.2	+	3	892	c.513T>C	c.(511-513)GCT>GCC	p.A171A	TACC1_uc011lby.1_5'UTR|TACC1_uc003xma.2_Intron|TACC1_uc003xlz.2_5'UTR|TACC1_uc003xmc.3_5'UTR|TACC1_uc011lbz.1_Silent_p.A187A|TACC1_uc003xmb.3_Silent_p.A126A|TACC1_uc003xme.1_Intron|TACC1_uc003xmd.1_Intron|TACC1_uc010lwo.1_Intron|TACC1_uc003xmf.3_Intron|TACC1_uc011lca.1_Silent_p.A171A|TACC1_uc011lcb.1_5'UTR|TACC1_uc011lcc.1_5'UTR|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_5'UTR|TACC1_uc010lwq.2_5'UTR	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	171	Interaction with TDRD7.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			CAAAAGCAGCTCATGGCTGTG	0.532													C	38677275	C	C	38677275	2	2	242	1	0	0	0	0	0	0	0	1	15498	1538	54	4		4	TACC1	8	38677275	Silent	SNP	T	TCGA-41-2571-01A-01D-1495-08		38677275	107686747	27	17260											
KANK1	23189	broad.mit.edu	37	chr9	732407	732407	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aacttcaagtgatgattccaGctcagatgaaagctcttctt	7	9	4	4			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr9:732407G>T	uc003zgl.1	+	10	3684	c.3035G>T	c.(3034-3036)AGC>ATC	p.S1012I	KANK1_uc003zgm.2_3'UTR|KANK1_uc003zgn.1_Missense_Mutation_p.S1012I|KANK1_uc003zgs.1_Missense_Mutation_p.S854I|KANK1_uc010mgx.1_5'UTR|KANK1_uc010mgy.1_5'UTR|KANK1_uc003zgt.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	1012					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GATGATTCCAGCTCAGATGAA	0.458													T	732407	T	T	732407	3	4	242	1	0	0	0	0	1	0	0	0	7976	971	34	5	3053	5	KANK1	9	732407	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08		732407	140481024	28	17261											
STXBP1	6812	broad.mit.edu	37	chr9	130444743	130444743	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgagtaccgcagtggccccCgcctcatcattttcatcctt	8	16	3	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr9:130444743C>T	uc004brl.2	+	18	1803	c.1606C>T	c.(1606-1608)CGC>TGC	p.R536C	STXBP1_uc004brk.2_Missense_Mutation_p.R536C	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	536					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						CAGTGGCCCCCGCCTCATCAT	0.562													T	130444743	T	T	130444743	3	4	242	1	0	0	0	0	1	0	0	0	15351	652	23	2	1676	2	STXBP1	9	130444743	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	129712336	130444743	10768688	29	17262											
LARP4B	23185	broad.mit.edu	37	chr10	882389	882389	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgcaatattactatgcagCgattttgatttggccttact	7	9	0	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr10:882389C>T	uc001ifs.1	-	7	745	c.704G>A	c.(703-705)CGC>CAC	p.R235H		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	235	HTH La-type RNA-binding.						nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						TACTATGCAGCGATTTTGATT	0.353													T	882389	T	T	882389	3	4	242	1	0	0	0	0	1	0	0	0	8631	768	27	1	1556	1	LARP4B	10	882389	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08		882389	134652358	30	17263											
CDH23	64072	broad.mit.edu	37	chr10	73462359	73462359	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccacagtgtttgtgaacctcTtggatctcaatgacaatgac	8	10	2	3			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr10:73462359T>C	uc001jrx.3	+	23	3018	c.2641T>C	c.(2641-2643)TTG>CTG	p.L881L	CDH23_uc001jry.2_Silent_p.L497L|CDH23_uc001jrz.2_Silent_p.L497L	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	881	Cadherin 8.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						TGTGAACCTCTTGGATCTCAA	0.577													C	73462359	C	C	73462359	2	2	242	1	0	0	0	0	0	0	0	1	3108	1606	56	4		4	CDH23	10	73462359	Silent	SNP	T	TCGA-41-2571-01A-01D-1495-08	72579970	73462359	62072388	31	17264											
PTEN	5728	broad.mit.edu	37	chr10	89717672	89717672	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctccaattcaggacccacaCgacgggaagacaagttcatg	9	13	2	1	rs121909219		TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr10:89717672C>T	uc001kfb.2	+	8	1728	c.697C>T	c.(697-699)CGA>TGA	p.R233*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R233*(61)|p.R233fs*10(4)|p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R233fs*25(1)|p.R233fs*23(1)|p.R233R(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGGACCCACACGACGGGAAGA	0.423	R233*(JHUEM1_ENDOMETRIUM)|R233*(SW1783_CENTRAL_NERVOUS_SYSTEM)|R233*(NCIH1155_LUNG)|R233*(SF295_CENTRAL_NERVOUS_SYSTEM)|R233*(HEC59_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89717672	T	T	89717672	4	4	242	1	0	0	0	0	0	1	0	0	12738	528	19	1	723	1	PTEN	10	89717672	Nonsense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	16255313	89717672	45817075	32	17265											
CALHM2	51063	broad.mit.edu	37	chr10	105209447	105209447	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcctccggtgctggcactcGgccacgaggttccaggtgtg	15	13	0	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr10:105209447G>A	uc001kwz.2	-	2	638	c.252C>T	c.(250-252)GCC>GCT	p.A84A	CALHM2_uc001kxa.2_Silent_p.A84A|CALHM2_uc001kxc.2_Silent_p.A84A|CALHM2_uc001kxb.2_Silent_p.A84A|CALHM2_uc001kxd.1_Silent_p.A84A	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	84						integral to membrane				skin(1)	1						GCTGGCACTCGGCCACGAGGT	0.647													A	105209447	A	A	105209447	2	1	242	1	0	0	0	0	0	0	0	1	2583	1103	39	2		2	CALHM2	10	105209447	Silent	SNP	G	TCGA-41-2571-01A-01D-1495-08	15491775	105209447	30325300	33	17266											
JAKMIP3	282973	broad.mit.edu	37	chr10	133954043	133954043	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcttaccaaacagacaggaCggaccagaccccgtgcaccc	8	17	1	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr10:133954043C>T	uc001lkx.3	+	9	1433	c.1433C>T	c.(1432-1434)ACG>ATG	p.T478M		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		ACAGACAGGACGGACCAGACC	0.607													T	133954043	T	T	133954043	3	4	242	1	0	0	0	0	1	0	0	0	7942	536	19	1	1467	1	JAKMIP3	10	133954043	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	28744596	133954043	1580704	34	17267											
EIF3M	10480	broad.mit.edu	37	chr11	32615446	32615446	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagtcatggtggaattgctcGgaagttacacagaggacaat	12	6	1	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr11:32615446G>A	uc001mtu.2	+	6	611	c.568G>A	c.(568-570)GGA>AGA	p.G190R	EIF3M_uc010ref.1_Missense_Mutation_p.G58R	NM_006360	NP_006351	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3,	190						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)|breast(1)|skin(1)	3	Breast(20;0.109)					GGAATTGCTCGGAAGTTACAC	0.378													A	32615446	A	A	32615446	3	1	242	1	0	0	0	0	1	0	0	0	5023	1117	39	2	590	2	EIF3M	11	32615446	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08		32615446	102391070	35	17268											
MS4A14	84689	broad.mit.edu	37	chr11	60183725	60183725	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcccatattgtgcagttcccTgaaatacaacacctacttca	4	13	1	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr11:60183725T>C	uc001npj.2	+	5	1849	c.1284T>C	c.(1282-1284)CCT>CCC	p.P428P	MS4A14_uc001npi.2_Silent_p.P316P|MS4A14_uc001npn.2_Silent_p.P166P|MS4A14_uc001npk.2_Silent_p.P411P|MS4A14_uc001npl.2_Silent_p.P166P|MS4A14_uc001npm.2_Silent_p.P166P	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	428	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						TGCAGTTCCCTGAAATACAAC	0.274													C	60183725	C	C	60183725	2	2	242	1	0	0	0	0	0	0	0	1	9858	1567	55	4		4	MS4A14	11	60183725	Silent	SNP	T	TCGA-41-2571-01A-01D-1495-08	27568279	60183725	74822791	36	17269											
HEPHL1	341208	broad.mit.edu	37	chr11	93796724	93796724	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggaacaaaaatgatgacatgGttcctcctgggaaaaactac	9	8	0	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr11:93796724G>T	uc001pep.2	+	3	623	c.466G>T	c.(466-468)GTT>TTT	p.V156F		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	156	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TGATGACATGGTTCCTCCTGG	0.418													T	93796724	T	T	93796724	3	4	242	1	0	0	0	0	1	0	0	0	7055	1261	44	5	476	5	HEPHL1	11	93796724	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	33612999	93796724	41209792	37	17270											
PIWIL4	143689	broad.mit.edu	37	chr11	94335056	94335056	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctggttgattttatgtagCgacagaactgaatatgttgc	10	6	0	3			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr11:94335056C>T	uc001pfa.2	+	12	1687	c.1476C>T	c.(1474-1476)AGC>AGT	p.S492S	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	492					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTTTATGTAGCGACAGAACTG	0.423													T	94335056	T	T	94335056	2	4	242	1	0	0	0	0	0	0	0	1	11960	767	27	1		1	PIWIL4	11	94335056	Silent	SNP	C	TCGA-41-2571-01A-01D-1495-08	538332	94335056	40671460	38	17271											
ANO2	57101	broad.mit.edu	37	chr12	5908716	5908716	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttatagaacactccatagcGcgcccattcttgatatagca	6	12	1	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr12:5908716G>A	uc001qnm.2	-	10	1072	c.1000C>T	c.(1000-1002)CGC>TGC	p.R334C		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	339	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						ACTCCATAGCGCGCCCATTCT	0.423													A	5908716	A	A	5908716	3	1	242	1	0	0	0	0	1	0	0	0	697	1087	38	1	2064	1	ANO2	12	5908716	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08		5908716	127943179	39	17272											
VWF	7450	broad.mit.edu	37	chr12	6128359	6128359	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccaccgggatcacaatgaCcttcttcttcttcaggccct	7	16	5	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr12:6128359C>T	uc001qnn.1	-	28	4475	c.4225G>A	c.(4225-4227)GTC>ATC	p.V1409I	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1409	VWFA 1; binding site for platelet glycoprotein Ib.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	ATCACAATGACCTTCTTCTTC	0.607													T	6128359	T	T	6128359	3	4	242	1	0	0	0	0	1	0	0	0	17243	507	18	3	4316	3	VWF	12	6128359	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	219643	6128359	127723536	40	17273											
ELK3	2004	broad.mit.edu	37	chr12	96641080	96641080	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtttgtgaccaataaaacCgacaagcacgtcaccaggcc	9	12	1	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr12:96641080C>T	uc001teo.1	+	3	849	c.570C>T	c.(568-570)ACC>ACT	p.T190T		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	190					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)					CCAATAAAACCGACAAGCACG	0.622													T	96641080	T	T	96641080	2	4	242	1	0	0	0	0	0	0	0	1	5060	639	23	2		2	ELK3	12	96641080	Silent	SNP	C	TCGA-41-2571-01A-01D-1495-08	90512721	96641080	37210815	41	17274											
UGGT2	55757	broad.mit.edu	37	chr13	96648323	96648323	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccattcagacttactttagtTtcccaaagagaaatccttga	5	10	1	3			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr13:96648323T>A	uc001vmt.2	-	7	994	c.824A>T	c.(823-825)AAA>ATA	p.K275I	UGGT2_uc010afo.2_RNA|UGGT2_uc001vmv.2_Missense_Mutation_p.K275I|UGGT2_uc010afp.2_Missense_Mutation_p.K275I	NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	275					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TTACTTTAGTTTCCCAAAGAG	0.313													A	96648323	A	A	96648323	3	1	242	1	0	0	0	0	1	0	0	0	16939	1841	64	5	3858	5	UGGT2	13	96648323	Missense_Mutation	SNP	T	TCGA-41-2571-01A-01D-1495-08		96648323	18521555	42	17275											
C14orf135	64430	broad.mit.edu	37	chr14	60582118	60582118	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gtgcaaactgtgactgtattCtttgagaagcaaactaggct	10	7	1	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr14:60582118C>G	uc001xer.3	+	3	1116	c.594C>G	c.(592-594)TTC>TTG	p.F198L	C14orf135_uc001xeq.2_Missense_Mutation_p.F198L|C14orf135_uc010apm.2_5'Flank	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	432						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		TGACTGTATTCTTTGAGAAGC	0.343													G	60582118	G	G	60582118	3	3	242	1	0	0	0	0	1	0	0	0	1745	912	32	5	600	5	C14orf135	14	60582118	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08		60582118	46767422	43	17276											
MAP2K1	5604	broad.mit.edu	37	chr15	66679706	66679706	+	Frame_Shift_Del	DEL	G	-	-													atgcccaagaagaagccgacGcccatccagctgaacccggc							TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr15:66679706delG	uc010bhq.2	+	1	496	c.21delG	c.(19-21)ACGfs	p.T7fs		NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	7					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						AGAAGCCGACGCCCATCCAGC	0.697									Cardiofaciocutaneous_syndrome				-	66679706	-	-	66679706	7	5	242	1	0	1	0	1	0	0	0	0	9236	1074	38	0	23	0	MAP2K1	15	66679706	Frame_Shift_Del	DEL	G	TCGA-41-2571-01A-01D-1495-08		66679706	35851686	44	17277											
SLC28A1	9154	broad.mit.edu	37	chr15	85478399	85478399	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcctggctgggagacatgGtggacatccaagggctcagc	14	11	2	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr15:85478399G>A	uc002blg.2	+	14	1559	c.1357G>A	c.(1357-1359)GTG>ATG	p.V453M	SLC28A1_uc010bnb.2_Missense_Mutation_p.V453M|SLC28A1_uc010upe.1_Intron|SLC28A1_uc010upf.1_Missense_Mutation_p.V453M|SLC28A1_uc010upg.1_Missense_Mutation_p.V453M	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	453					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGGAGACATGGTGGACATCCA	0.592													A	85478399	A	A	85478399	3	1	242	1	0	0	0	0	1	0	0	0	14531	1261	44	3	1474	3	SLC28A1	15	85478399	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	18798693	85478399	17052993	45	17278											
MFGE8	4240	broad.mit.edu	37	chr15	89453040	89453040	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactcgtctcacagtggttgCccgcgtagcccttaaggcac	10	15	1	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr15:89453040C>T	uc002bng.3	-	2	301	c.188G>A	c.(187-189)GGC>GAC	p.G63D	MFGE8_uc002bnf.3_5'UTR|MFGE8_uc002bnh.3_Missense_Mutation_p.G63D|MFGE8_uc010bnn.2_Missense_Mutation_p.G55D|MFGE8_uc010upq.1_Intron|MFGE8_uc010upr.1_Missense_Mutation_p.G63D|MFGE8_uc010bno.2_Intron	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	63	EGF-like.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					ACAGTGGTTGCCCGCGTAGCC	0.572													T	89453040	T	T	89453040	3	4	242	1	0	0	0	0	1	0	0	0	9520	739	26	3	1003	3	MFGE8	15	89453040	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	3974641	89453040	13078352	46	17279											
APOB48R	55911	broad.mit.edu	37	chr16	28507386	28507386	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaggccgggatagcctcaGgcggggaggctgggacagcc	20	10	1	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr16:28507386G>A	uc002dqb.1	+	2	1034	c.1024G>A	c.(1024-1026)GGC>AGC	p.G342S	uc010vct.1_Intron|APOB48R_uc010byg.1_5'UTR	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	342	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						GATAGCCTCAGGCGGGGAGGC	0.721													A	28507386	A	A	28507386	3	1	242	1	0	0	0	0	1	0	0	0	786	1000	35	3	1030	3	APOB48R	16	28507386	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08		28507386	61847367	47	17280											
ALDOA	226	broad.mit.edu	37	chr16	30080984	30080984	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcgccgcacagtgcccccCgctgtcactggtgaggccca	12	18	1	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr16:30080984C>T	uc002dvw.2	+	10	1917	c.789C>T	c.(787-789)CCC>CCT	p.P263P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ALDOA_uc002dvx.2_Silent_p.P263P|ALDOA_uc002dvy.2_Silent_p.P263P|ALDOA_uc002dvz.2_Silent_p.P263P|ALDOA_uc002dwa.3_Silent_p.P263P|ALDOA_uc002dwb.1_Silent_p.P263P|ALDOA_uc002dwc.2_Silent_p.P263P|ALDOA_uc010veg.1_Silent_p.P317P|ALDOA_uc002dwd.2_Silent_p.P267P	NM_184043	NP_908932	P04075	ALDOA_HUMAN	fructose-bisphosphate aldolase A	263					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			lung(1)	1						CAGTGCCCCCCGCTGTCACTG	0.562													T	30080984	T	T	30080984	2	4	242	1	0	0	0	0	0	0	0	1	507	639	23	2		2	ALDOA	16	30080984	Silent	SNP	C	TCGA-41-2571-01A-01D-1495-08	1573598	30080984	60273769	48	17281											
KIAA0182	23199	broad.mit.edu	37	chr16	85701868	85701868	+	Frame_Shift_Del	DEL	C	-	-													agcacaatgggcagcaggagCcccccactgcaaggaagggc							TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr16:85701868delC	uc002fix.2	+	14	3327	c.3253delC	c.(3253-3255)CCCfs	p.P1085fs	KIAA0182_uc002fiw.2_Frame_Shift_Del_p.P981fs|KIAA0182_uc002fiy.2_Frame_Shift_Del_p.P1012fs|KIAA0182_uc002fiz.2_Frame_Shift_Del_p.P227fs|KIAA0182_uc010cho.2_Frame_Shift_Del_p.P265fs	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	1085							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						GCAGCAGGAGCCCCCCACTGC	0.483													-	85701868	-	-	85701868	7	5	242	1	0	1	0	1	0	0	0	0	8159	739	26	0	3307	0	KIAA0182	16	85701868	Frame_Shift_Del	DEL	C	TCGA-41-2571-01A-01D-1495-08	55620884	85701868	4652885	49	17282											
ABR	29	broad.mit.edu	37	chr17	914060	914060	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgagcgtcccggcgatggcGttgatgtccatgtcactcag	13	11	2	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr17:914060G>A	uc002fsd.2	-	20	2255	c.2145C>T	c.(2143-2145)AAC>AAT	p.N715N	ABR_uc002fse.2_Silent_p.N669N|ABR_uc010vqf.1_Silent_p.N166N|ABR_uc010vqg.1_Silent_p.N497N|ABR_uc002fsg.2_Silent_p.N678N|ABR_uc002fsh.1_Silent_p.N323N|ABR_uc002fsf.2_Silent_p.N252N	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	715	Rho-GAP.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		CGGCGATGGCGTTGATGTCCA	0.637													A	914060	A	A	914060	2	1	242	1	0	0	0	0	0	0	0	1	99	1136	40	1		1	ABR	17	914060	Silent	SNP	G	TCGA-41-2571-01A-01D-1495-08		914060	80281150	50	17283											
MNT	4335	broad.mit.edu	37	chr17	2290511	2290511	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcaggcgccagttgcaccGcagggctgggggccgagggg	21	11	0	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr17:2290511G>A	uc002fur.2	-	6	1685	c.1433C>T	c.(1432-1434)GCG>GTG	p.A478V		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	478					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			skin(1)	1				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		CAGTTGCACCGCAGGGCTGGG	0.667													A	2290511	A	A	2290511	3	1	242	1	0	0	0	0	1	0	0	0	9678	1087	38	1	319	1	MNT	17	2290511	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	1376451	2290511	78904699	51	17284											
KCNJ12	3768	broad.mit.edu	37	chr17	21319073	21319073	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcctcttctccatcgagaCgcagaccaccatcggctacg	7	17	2	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr17:21319073C>T	uc002gyv.1	+	3	1124	c.419C>T	c.(418-420)ACG>ATG	p.T140M		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	140					blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TCCATCGAGACGCAGACCACC	0.667										Prostate(3;0.18)			T	21319073	T	T	21319073	3	4	242	1	0	0	0	0	1	0	0	0	8046	536	19	1	421	1	KCNJ12	17	21319073	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	19028562	21319073	59876137	52	17285											
COL1A1	1277	broad.mit.edu	37	chr17	48268238	48268238	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gggccagtcagaccacggacGccatctttgccaggagagcc	13	14	2	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr17:48268238G>T	uc002iqm.2	-	33	2409	c.2283C>A	c.(2281-2283)GGC>GGA	p.G761G		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	761	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	GACCACGGACGCCATCTTTGC	0.587			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						T	48268238	T	T	48268238	2	4	242	1	0	0	0	0	0	0	0	1	3677	1074	38	5		5	COL1A1	17	48268238	Silent	SNP	G	TCGA-41-2571-01A-01D-1495-08	26949165	48268238	32926972	53	17286											
GPR142	350383	broad.mit.edu	37	chr17	72367987	72367987	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaggtggtcatcgtgttcGcgggcttcctcctgcaggga	14	12	1	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr17:72367987G>A	uc010wqy.1	+	4	637	c.637G>A	c.(637-639)GCG>ACG	p.A213T	GPR142_uc010wqx.1_Missense_Mutation_p.A125T	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	213	Helical; Name=2; (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CATCGTGTTCGCGGGCTTCCT	0.652													A	72367987	A	A	72367987	3	1	242	1	0	0	0	0	1	0	0	0	6650	1087	38	1	651	1	GPR142	17	72367987	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	24099749	72367987	8827223	54	17287											
MCART2	147407	broad.mit.edu	37	chr18	29339972	29339972	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	acatggcacccaatagacctCcaccgataaaatcattgacc	5	14	1	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr18:29339972C>G	uc002kxa.2	-	1	872	c.653G>C	c.(652-654)GGA>GCA	p.G218A		NM_001034172	NP_001029344	Q3SY17	MCAR2_HUMAN	mitochondrial carrier triple repeat 2	218	Helical; Name=5; (Potential).|Solcar 3.				transport	integral to membrane|mitochondrial inner membrane				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.0539)			CAATAGACCTCCACCGATAAA	0.458													G	29339972	G	G	29339972	3	3	242	1	0	0	0	0	1	0	0	0	9370	855	30	5	244	5	MCART2	18	29339972	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08		29339972	48737276	55	17288											
SLC14A2	8170	broad.mit.edu	37	chr18	43205722	43205722	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaggagtaaaaggaaagaCgacggggtggcccatcggga	17	6	0	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr18:43205722C>T	uc010dnj.2	+	4	546	c.225C>T	c.(223-225)GAC>GAT	p.D75D	SLC14A2_uc002lbb.2_Silent_p.D75D|SLC14A2_uc002lbe.2_Silent_p.D75D	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	75						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						AAAGGAAAGACGACGGGGTGG	0.517													T	43205722	T	T	43205722	2	4	242	1	0	0	0	0	0	0	0	1	14397	535	19	1		1	SLC14A2	18	43205722	Silent	SNP	C	TCGA-41-2571-01A-01D-1495-08	13865750	43205722	34871526	56	17289											
DUS3L	56931	broad.mit.edu	37	chr19	5785666	5785666	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgccgggtcttctccacgcCctgcgtgtccgagccccagt	12	18	2	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr19:5785666C>T	uc002mdc.2	-	11	1796	c.1699G>A	c.(1699-1701)GGC>AGC	p.G567S	PRR22_uc002mdb.1_5'Flank|PRR22_uc010xiv.1_5'Flank|DUS3L_uc002mdd.2_Missense_Mutation_p.G325S|DUS3L_uc010duk.2_Missense_Mutation_p.G232S	NM_020175	NP_064560	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like isoform 1	567					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding				0						TTCTCCACGCCCTGCGTGTCC	0.706													T	5785666	T	T	5785666	3	4	242	1	0	0	0	0	1	0	0	0	4807	623	22	3	265	3	DUS3L	19	5785666	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08		5785666	53343317	57	17290											
CD209	30835	broad.mit.edu	37	chr19	7809880	7809880	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccccacttctttgcaggCggtgatggagtcgtgccagt	14	12	1	1	rs139712001	byFrequency	TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr19:7809880C>T	uc002mht.2	-	5	914	c.847G>A	c.(847-849)GCC>ACC	p.A283T	CD209_uc010xju.1_Missense_Mutation_p.A122T|CD209_uc010dvp.2_Missense_Mutation_p.A259T|CD209_uc002mhr.2_Missense_Mutation_p.A259T|CD209_uc002mhs.2_Missense_Mutation_p.A213T|CD209_uc002mhu.2_Missense_Mutation_p.A191T|CD209_uc010dvq.2_Missense_Mutation_p.A283T|CD209_uc002mhq.2_Missense_Mutation_p.A283T|CD209_uc002mhv.2_Missense_Mutation_p.A259T|CD209_uc002mhx.2_Missense_Mutation_p.A239T|CD209_uc002mhw.2_Missense_Mutation_p.A147T|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	283	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						TCTTTGCAGGCGGTGATGGAG	0.582													T	7809880	T	T	7809880	3	4	242	1	0	0	0	0	1	0	0	0	2984	768	27	1	379	1	CD209	19	7809880	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	2024214	7809880	51319103	58	17291											
ARMC6	93436	broad.mit.edu	37	chr19	19166113	19166113	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgagcaccctgcgagccatcGcaggcaacgacgacgtgaaa	12	13	0	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr19:19166113G>T	uc002nld.2	+	7	1411	c.1063G>T	c.(1063-1065)GCA>TCA	p.A355S	ARMC6_uc002nlc.2_Missense_Mutation_p.A330S|ARMC6_uc010xql.1_Missense_Mutation_p.A262S|ARMC6_uc002nle.2_Missense_Mutation_p.A330S|ARMC6_uc010xqm.1_Missense_Mutation_p.A355S	NM_033415	NP_219483	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	355	ARM 3.						protein binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			GCGAGCCATCGCAGGCAACGA	0.627													T	19166113	T	T	19166113	3	4	242	1	0	0	0	0	1	0	0	0	955	1087	38	5	1006	5	ARMC6	19	19166113	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	11356233	19166113	39962870	59	17292											
PSG8	440533	broad.mit.edu	37	chr19	43259170	43259170	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagggtgactgggtaactgcGgatgccaccatattggtccc	13	11	0	1			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr19:43259170G>A	uc002ouo.2	-	4	1056	c.958C>T	c.(958-960)CGC>TGC	p.R320C	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_Intron|PSG8_uc002oui.2_Missense_Mutation_p.R159C|PSG8_uc002ouh.2_Missense_Mutation_p.R320C|PSG8_uc010ein.2_Missense_Mutation_p.R198C|PSG8_uc002ouj.3_Missense_Mutation_p.R102C|PSG8_uc002ouk.3_Missense_Mutation_p.R159C|PSG8_uc002oul.3_Missense_Mutation_p.R320C|PSG8_uc002oum.3_Missense_Mutation_p.R227C|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.R227C	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	320	Ig-like C2-type 2.					extracellular region					0		Prostate(69;0.00899)				GGGTAACTGCGGATGCCACCA	0.483													A	43259170	A	A	43259170	3	1	242	1	0	0	0	0	1	0	0	0	12661	1116	39	2	351	2	PSG8	19	43259170	Missense_Mutation	SNP	G	TCGA-41-2571-01A-01D-1495-08	24093057	43259170	15869813	60	17293											
FAM71E1	112703	broad.mit.edu	37	chr19	50978584	50978584	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgaggtgggggcagttacccGaagagttgcaggtgtccgtt	17	7	0	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr19:50978584G>A	uc002psh.2	-	3	895	c.537C>T	c.(535-537)TTC>TTT	p.F179F	FAM71E1_uc002psg.2_Silent_p.F163F|FAM71E1_uc002psi.2_RNA|C19orf63_uc002psj.2_5'Flank|C19orf63_uc002psk.2_5'Flank|C19orf63_uc002psl.2_5'Flank	NM_138411	NP_612420	Q6IPT2	F71E1_HUMAN	hypothetical protein LOC112703	179										breast(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		GCAGTTACCCGAAGAGTTGCA	0.672													A	50978584	A	A	50978584	2	1	242	1	0	0	0	0	0	0	0	1	5611	1049	37	2		2	FAM71E1	19	50978584	Silent	SNP	G	TCGA-41-2571-01A-01D-1495-08	7719414	50978584	8150399	61	17294											
JAG1	182	broad.mit.edu	37	chr20	10653470	10653470	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccgaagctgcagggccccCcggccgtgacgcgggactga	16	15	0	2			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr20:10653470C>T	uc002wnw.2	-	2	782	c.266G>A	c.(265-267)GGG>GAG	p.G89E		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	89	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GCAGGGCCCCCCGGCCGTGAC	0.667									Alagille_Syndrome				T	10653470	T	T	10653470	3	4	242	1	0	0	0	0	1	0	0	0	7934	623	22	3	3490	3	JAG1	20	10653470	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08		10653470	52372050	62	17295											
MACROD2	140733	broad.mit.edu	37	chr20	15210608	15210608	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtcatccatactgtagggccAatagccaggggccatattaa	10	10	1	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr20:15210608A>T	uc002wou.2	+	6	705	c.441A>T	c.(439-441)CCA>CCT	p.P147P	MACROD2_uc002wot.2_Silent_p.P147P|MACROD2_uc002woz.2_5'UTR	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	147	Macro.										0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				CTGTAGGGCCAATAGCCAGGG	0.353													T	15210608	T	T	15210608	2	4	242	1	0	0	0	0	0	0	0	1	9146	117	5	5		5	MACROD2	20	15210608	Silent	SNP	A	TCGA-41-2571-01A-01D-1495-08	4557138	15210608	47814912	63	17296											
C22orf43	51233	broad.mit.edu	37	chr22	23974205	23974205	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atacaacaggtcagtatattCcccatggggcctctccatgc	8	13	2	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr22:23974205C>T	uc002zxf.2	-	1	283	c.6G>A	c.(4-6)GGG>GGA	p.G2G		NM_016449	NP_057533	Q6PGQ1	CV043_HUMAN	hypothetical protein LOC51233	2										skin(1)	1						TCAGTATATTCCCCATGGGGC	0.547													T	23974205	T	T	23974205	2	4	242	1	0	0	0	0	0	0	0	1	2150	842	30	3		3	C22orf43	22	23974205	Silent	SNP	C	TCGA-41-2571-01A-01D-1495-08		23974205	27330361	64	17297											
SF3A1	10291	broad.mit.edu	37	chr22	30738319	30738319	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacgttcctggaatttggcCcattccactcggtaacacac	7	14	1	0			TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr22:30738319C>T	uc003ahl.2	-	6	879	c.747G>A	c.(745-747)TGG>TGA	p.W249*		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	249					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						GGAATTTGGCCCATTCCACTC	0.458													T	30738319	T	T	30738319	4	4	242	1	0	0	0	0	0	1	0	0	14146	624	22	3	1678	3	SF3A1	22	30738319	Nonsense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	6764114	30738319	20566247	65	17298											
FAM118A	55007	broad.mit.edu	37	chr22	45723798	45723798	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgacctggagcagcacatcCggagtcctgtggtgctgcag	14	12	0	0	rs140683394		TCGA-41-2571-01A-01D-1495-08	TCGA-41-2571-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	36349a22-17eb-48d8-9b69-1921ee7576ff	d83625bf-b6c1-45d8-b49a-e3ffeb2fc951	g.chr22:45723798C>T	uc003bfz.3	+	5	992	c.376C>T	c.(376-378)CGG>TGG	p.R126W	FAM118A_uc003bga.3_Missense_Mutation_p.R126W|uc011aqp.1_5'Flank|uc011aqq.1_5'Flank|FAM118A_uc011aqr.1_5'Flank	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	126						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		GCAGCACATCCGGAGTCCTGT	0.592													T	45723798	T	T	45723798	3	4	242	1	0	0	0	0	1	0	0	0	5411	643	23	2	386	2	FAM118A	22	45723798	Missense_Mutation	SNP	C	TCGA-41-2571-01A-01D-1495-08	14985479	45723798	5580768	66	17299											
IL22RA1	58985	broad.mit.edu	37	chr1	24465095	24465095	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttatactcgatgctgtagacCgtgtctggggtgccctccgg	13	11	1	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr1:24465095C>T	uc001biq.1	-	2	192	c.153G>A	c.(151-153)ACG>ACA	p.T51T	IL22RA1_uc010oeg.1_5'Flank|IL22RA1_uc009vrb.1_5'UTR|IL22RA1_uc010oeh.1_Silent_p.T51T	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	51	Extracellular (Potential).|Fibronectin type-III 1.					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		TGCTGTAGACCGTGTCTGGGG	0.567													T	24465095	T	T	24465095	2	4	243	1	0	0	0	0	0	0	0	1	7673	639	23	2		2	IL22RA1	1	24465095	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08		24465095	224785526	1	17300											
PTAFR	5724	broad.mit.edu	37	chr1	28477494	28477494	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	atcgggaagagagtgtatcgGaactcagagtccatgtggga	15	6	1	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr1:28477494G>A	uc001bpl.2	-	2	166	c.39C>T	c.(37-39)TTC>TTT	p.F13F	PTAFR_uc001bpm.3_Silent_p.F13F|PTAFR_uc009vte.2_Silent_p.F13F	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	13	Extracellular (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		GAGTGTATCGGAACTCAGAGT	0.527													A	28477494	A	A	28477494	2	1	243	1	0	0	0	0	0	0	0	1	12723	1165	41	3		3	PTAFR	1	28477494	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08	4012399	28477494	220773127	2	17301											
GLIS1	148979	broad.mit.edu	37	chr1	53995480	53995480	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctaccgtgtctaggtgggtgCgctggtgcttggcgcggtcg	18	10	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr1:53995480C>T	uc001cvr.1	-	4	1508	c.941G>A	c.(940-942)CGC>CAC	p.R314H		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	314	C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						TAGGTGGGTGCGCTGGTGCTT	0.657													T	53995480	T	T	53995480	3	4	243	1	0	0	0	0	1	0	0	0	6445	768	27	1	949	1	GLIS1	1	53995480	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	25517986	53995480	195255141	3	17302											
ADAM30	11085	broad.mit.edu	37	chr1	120437661	120437661	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctacagttggcacctggttgCaacttacaatttgattggca	9	9	0	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr1:120437661C>A	uc001eij.2	-	1	1453	c.1299G>T	c.(1297-1299)TTG>TTT	p.L433F		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	433	Disintegrin.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CACCTGGTTGCAACTTACAAT	0.453													A	120437661	A	A	120437661	3	1	243	1	0	0	0	0	1	0	0	0	248	709	25	5	1077	5	ADAM30	1	120437661	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	66442181	120437661	128812960	4	17303											
SEMA4A	64218	broad.mit.edu	37	chr1	156126258	156126258	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agaagggcctccaggattttGacactctgctcctgagtggt	12	10	1	3			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr1:156126258G>C	uc001fnl.2	+	3	297	c.193G>C	c.(193-195)GAC>CAC	p.D65H	SEMA4A_uc009wrq.2_Missense_Mutation_p.D65H|SEMA4A_uc001fnm.2_Missense_Mutation_p.D65H|SEMA4A_uc001fnn.2_5'UTR|SEMA4A_uc001fno.2_Missense_Mutation_p.D65H	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	65	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCAGGATTTTGACACTCTGCT	0.542													C	156126258	C	C	156126258	3	2	243	1	0	0	0	0	1	0	0	0	14031	1290	45	5	199	5	SEMA4A	1	156126258	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	35688597	156126258	93124363	5	17304											
ILDR2	387597	broad.mit.edu	37	chr1	166888604	166888604	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacaacatcagaccacaagGgacatcctggttggaaagtc	10	10	1	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr1:166888604G>A	uc001gdx.1	-	10	1964	c.1908C>T	c.(1906-1908)TCC>TCT	p.S636S		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	636	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						AGACCACAAGGGACATCCTGG	0.438													A	166888604	A	A	166888604	2	1	243	1	0	0	0	0	0	0	0	1	7710	1219	43	3		3	ILDR2	1	166888604	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08	10762346	166888604	82362017	6	17305											
PTPRC	5788	broad.mit.edu	37	chr1	198676014	198676014	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttacagaatgtaaaaatgcGtctgtttccatatctcataa	5	8	2	1	rs137909392	byFrequency	TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr1:198676014G>A	uc001gur.1	+	9	1011	c.831G>A	c.(829-831)GCG>GCA	p.A277A	PTPRC_uc001gus.1_Silent_p.A229A|PTPRC_uc001gut.1_Silent_p.A116A|PTPRC_uc009wzf.1_Silent_p.A165A|PTPRC_uc010ppg.1_Silent_p.A213A	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	277	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GTAAAAATGCGTCTGTTTCCA	0.289													A	198676014	A	A	198676014	2	1	243	1	0	0	0	0	0	0	0	1	12797	1132	40	1		1	PTPRC	1	198676014	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08	31787410	198676014	50574607	7	17306											
OR13G1	441933	broad.mit.edu	37	chr1	247835982	247835982	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaagagggaaacaaatggccAcatagcggtcataggccatg	13	8	1	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr1:247835982A>C	uc001idi.1	-	1	362	c.362T>G	c.(361-363)GTG>GGG	p.V121G		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ACAAATGGCCACATAGCGGTC	0.478													C	247835982	C	C	247835982	3	2	243	1	0	0	0	0	1	0	0	0	10942	159	6	5	565	5	OR13G1	1	247835982	Missense_Mutation	SNP	A	TCGA-41-2572-01A-01D-1353-08	49159968	247835982	1414639	8	17307											
ITSN2	50618	broad.mit.edu	37	chr2	24435600	24435600	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggggcattcctttacaccgCgggtcagatgccagcttctg	12	12	2	1	rs146758206	byFrequency	TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr2:24435600C>T	uc002rfe.2	-	33	4266	c.4008G>A	c.(4006-4008)CCG>CCA	p.P1336P	ITSN2_uc002rff.2_Silent_p.P1309P	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	1336	DH.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTTACACCGCGGGTCAGATG	0.542													T	24435600	T	T	24435600	2	4	243	1	0	0	0	0	0	0	0	1	7927	755	27	1		1	ITSN2	2	24435600	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08		24435600	218763773	9	17308											
ST6GAL2	84620	broad.mit.edu	37	chr2	107450522	107450522	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacctgcgaattaatgatgcGtatggtggttttattcccaa	9	7	0	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr2:107450522G>A	uc002tdq.2	-	3	1143	c.1024C>T	c.(1024-1026)CGC>TGC	p.R342C	ST6GAL2_uc002tdr.2_Missense_Mutation_p.R342C|ST6GAL2_uc002tds.3_Missense_Mutation_p.R342C	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	342	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						TTAATGATGCGTATGGTGGTT	0.393													A	107450522	A	A	107450522	3	1	243	1	0	0	0	0	1	0	0	0	15221	1145	40	1	668	1	ST6GAL2	2	107450522	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	83014922	107450522	135748851	10	17309											
GALNT13	114805	broad.mit.edu	37	chr2	155099239	155099239	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagttgacattagagaattaCgtgaaaaatttagaagtgcc	9	4	0	4			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr2:155099239C>T	uc002tyr.3	+	6	1074	c.507C>T	c.(505-507)TAC>TAT	p.Y169Y	GALNT13_uc002tyt.3_Silent_p.Y169Y|GALNT13_uc010foc.1_Translation_Start_Site	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	169	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TAGAGAATTACGTGAAAAATT	0.353													T	155099239	T	T	155099239	2	4	243	1	0	0	0	0	0	0	0	1	6211	547	19	1		1	GALNT13	2	155099239	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08	47648717	155099239	88100134	11	17310											
XIRP2	129446	broad.mit.edu	37	chr2	168105145	168105145	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggctaaaatcataacaggaAaaaccggtgtgttgccacct	9	9	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr2:168105145A>G	uc002udx.2	+	8	7261	c.7243A>G	c.(7243-7245)AAA>GAA	p.K2415E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.K2240E|XIRP2_uc010fpq.2_Missense_Mutation_p.K2193E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2240					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CATAACAGGAAAAACCGGTGT	0.438													G	168105145	G	G	168105145	3	3	243	1	0	0	0	0	1	0	0	0	17427	15	1	4	7273	4	XIRP2	2	168105145	Missense_Mutation	SNP	A	TCGA-41-2572-01A-01D-1353-08	13005906	168105145	75094228	12	17311											
TTN	7273	broad.mit.edu	37	chr2	179398164	179398164	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catctttctcccattttaatGttggtggggggatgccagac	11	9	2	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr2:179398164G>A	uc010zfg.1	-	307	95698	c.95474C>T	c.(95473-95475)ACA>ATA	p.T31825I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T25520I|TTN_uc010zfi.1_Missense_Mutation_p.T25453I|TTN_uc010zfj.1_Missense_Mutation_p.T25328I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32752							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATTTTAATGTTGGTGGGGG	0.463													A	179398164	A	A	179398164	3	1	243	1	0	0	0	0	1	0	0	0	16732	1377	48	3	4821	3	TTN	2	179398164	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	11293019	179398164	63801209	13	17312											
FBLN2	2199	broad.mit.edu	37	chr3	13659763	13659763	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggcttctcactgcaggaCgatggccgcacttgccgccc	11	17	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr3:13659763C>T	uc011avb.1	+	6	2042	c.1917C>T	c.(1915-1917)GAC>GAT	p.D639D	FBLN2_uc011auz.1_Silent_p.D665D|FBLN2_uc011ava.1_Silent_p.D639D|FBLN2_uc011avc.1_Silent_p.D639D	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	639	EGF-like 1; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CACTGCAGGACGATGGCCGCA	0.612													T	13659763	T	T	13659763	2	4	243	1	0	0	0	0	0	0	0	1	5699	535	19	1		1	FBLN2	3	13659763	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08		13659763	184362667	14	17313											
SCN10A	6336	broad.mit.edu	37	chr3	38812783	38812783	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tactcacgccagggtaatgaCgctaaaatccagccagttcc	8	13	1	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr3:38812783C>T	uc003ciq.2	-	4	586	c.586G>A	c.(586-588)GTC>ATC	p.V196I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	196	I.|Helical; Name=S3 of repeat I; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AGGGTAATGACGCTAAAATCC	0.353													T	38812783	T	T	38812783	3	4	243	1	0	0	0	0	1	0	0	0	13912	536	19	1	5380	1	SCN10A	3	38812783	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	25153020	38812783	159209647	15	17314											
GPX1	2876	broad.mit.edu	37	chr3	49395545	49395545	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcagctcgttcatctgggtgTagtcccggaccgtggtgcct	14	12	2	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr3:49395545T>G	uc011bcl.1	-	2	247	c.167A>C	c.(166-168)TAC>TCC	p.Y56S	GPX1_uc011bcm.1_Missense_Mutation_p.Y56S	NM_000581	NP_000572	P07203	GPX1_HUMAN	glutathione peroxidase 1 isoform 1	56					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CATCTGGGTGTAGTCCCGGAC	0.657													G	49395545	G	G	49395545	3	3	243	1	0	0	0	0	1	0	0	0	6739	1638	57	5	497	5	GPX1	3	49395545	Missense_Mutation	SNP	T	TCGA-41-2572-01A-01D-1353-08	10582762	49395545	148626885	16	17315											
KIAA1407	57577	broad.mit.edu	37	chr3	113684122	113684122	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actaccttcctacgaagttgCtgtcgcctttcttcttttac	5	13	2	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr3:113684122C>T	uc003eax.2	-	17	2838	c.2691G>A	c.(2689-2691)CAG>CAA	p.Q897Q		NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	897										ovary(2)	2						TACGAAGTTGCTGTCGCCTTT	0.408													T	113684122	T	T	113684122	2	4	243	1	0	0	0	0	0	0	0	1	8229	796	28	3		3	KIAA1407	3	113684122	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08	64288577	113684122	84338308	17	17316											
RAB43	339122	broad.mit.edu	37	chr3	128813923	128813923	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagctcctcttggtgatgtcGtaggcaaggatggccccatt	13	10	1	1	rs145101068		TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr3:128813923G>A	uc003eln.1	-	2	581	c.294C>T	c.(292-294)TAC>TAT	p.Y98Y	RAB43_uc003elo.1_Missense_Mutation_p.T314M|RAB43_uc010hsy.1_Silent_p.Y98Y	NM_198490	NP_940892	Q86YS6	RAB43_HUMAN	RAB43 protein	98					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			lung(1)	1						TGGTGATGTCGTAGGCAAGGA	0.572													A	128813923	A	A	128813923	2	1	243	1	0	0	0	0	0	0	0	1	12945	1140	40	1		1	RAB43	3	128813923	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08	15129801	128813923	69208507	18	17317											
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	10	7	1	2	rs121913279		TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr3:178952085A>G	uc003fjk.2	+	21	3297	c.3140A>G	c.(3139-3141)CAT>CGT	p.H1047R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			G	178952085	G	G	178952085	3	3	243	1	0	0	0	0	1	0	0	0	11913	217	8	4	3218	4	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-41-2572-01A-01D-1353-08	50138162	178952085	19070345	19	17318											
SPON2	10417	broad.mit.edu	37	chr4	1161329	1161329	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggggctcccgttgttggcGggctggacccggacgtagcg	18	12	0	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr4:1161329G>A	uc003gcn.3	-	5	954	c.927C>T	c.(925-927)CCC>CCT	p.P309P	SPON2_uc003gco.3_Silent_p.P309P|SPON2_uc010ibr.2_Silent_p.P309P|SPON2_uc003gcm.1_3'UTR	NM_012445	NP_036577	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	309	TSP type-1.				axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		CGTTGTTGGCGGGCTGGACCC	0.682											OREG0016030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	1161329	A	A	1161329	2	1	243	1	0	0	0	0	0	0	0	1	15082	1103	39	2		2	SPON2	4	1161329	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08		1161329	189992947	20	17319											
C4orf44	345222	broad.mit.edu	37	chr4	3251162	3251162	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaagcagaccaagcgcaaCgccaaggtgtacgagaagat	11	11	1	3	rs143238822		TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr4:3251162C>T	uc003ggs.2	+	1	396	c.213C>T	c.(211-213)AAC>AAT	p.N71N	C4orf44_uc003ggt.2_Silent_p.N71N	NM_001042690	NP_001036155	Q6ZTZ1	CD044_HUMAN	hypothetical protein LOC345222 isoform a	71											0						CCAAGCGCAACGCCAAGGTGT	0.612													T	3251162	T	T	3251162	2	4	243	1	0	0	0	0	0	0	0	1	2272	535	19	1		1	C4orf44	4	3251162	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08	2089833	3251162	187903114	21	17320											
HS3ST1	9957	broad.mit.edu	37	chr4	11401289	11401289	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggtcttctccactgtgagcTggtgtggccaggagaagggc	17	9	2	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr4:11401289T>C	uc003gmq.2	-	2	664	c.341A>G	c.(340-342)CAG>CGG	p.Q114R		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	114						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						CACTGTGAGCTGGTGTGGCCA	0.617													C	11401289	C	C	11401289	3	2	243	1	0	0	0	0	1	0	0	0	7363	1580	55	4	586	4	HS3ST1	4	11401289	Missense_Mutation	SNP	T	TCGA-41-2572-01A-01D-1353-08	8150127	11401289	179752987	22	17321											
GRSF1	2926	broad.mit.edu	37	chr4	71691907	71691907	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggacaaaatgcagagaagaCgtagttccaaaatcagcagc	10	8	1	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr4:71691907C>A	uc010iia.1	-	7	1274	c.1191G>T	c.(1189-1191)ACG>ACT	p.T397T	GRSF1_uc011caz.1_Silent_p.T279T|GRSF1_uc003hfs.2_Silent_p.T235T	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	397					mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			GCAGAGAAGACGTAGTTCCAA	0.423													A	71691907	A	A	71691907	2	1	243	1	0	0	0	0	0	0	0	1	6809	523	19	5		5	GRSF1	4	71691907	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08	60290618	71691907	119462369	23	17322											
TET2	54790	broad.mit.edu	37	chr4	106155901	106155901	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctgtgagatcactcacccaTcgcatacctcagggcagatc	8	15	3	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr4:106155901T>G	uc003hxk.2	+	3	1188	c.802T>G	c.(802-804)TCG>GCG	p.S268A	TET2_uc011cez.1_Missense_Mutation_p.S289A|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.S268A|TET2_uc003hxi.1_Missense_Mutation_p.S268A	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	268					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CACTCACCCATCGCATACCTC	0.498			Mis N|F		MDS								G	106155901	G	G	106155901	3	3	243	1	0	0	0	0	1	0	0	0	15767	1435	50	5	804	5	TET2	4	106155901	Missense_Mutation	SNP	T	TCGA-41-2572-01A-01D-1353-08	34463994	106155901	84998375	24	17323											
ACSL1	2180	broad.mit.edu	37	chr4	185681554	185681554	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acacctgagcaacaggctcaCttcgcatgtagatattttca	7	11	2	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr4:185681554C>G	uc003iww.2	-	18	2033	c.1739G>C	c.(1738-1740)AGT>ACT	p.S580T	ACSL1_uc011ckm.1_Missense_Mutation_p.S409T|ACSL1_uc003iwt.1_Missense_Mutation_p.S580T|ACSL1_uc003iwu.1_Missense_Mutation_p.S580T|ACSL1_uc011ckn.1_Missense_Mutation_p.S546T|ACSL1_uc003iws.1_Missense_Mutation_p.S140T	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	580	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AACAGGCTCACTTCGCATGTA	0.443													G	185681554	G	G	185681554	3	3	243	1	0	0	0	0	1	0	0	0	177	565	20	5	373	5	ACSL1	4	185681554	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	79525653	185681554	5472722	25	17324											
RNASEN	29102	broad.mit.edu	37	chr5	31508865	31508865	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtcctcatcagactcacactCggattcactggaactctcta	6	14	5	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr5:31508865C>T	uc003jhg.2	-	9	1809	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	RNASEN_uc003jhh.2_Missense_Mutation_p.E447K|RNASEN_uc003jhi.2_Missense_Mutation_p.E447K|RNASEN_uc010iui.1_Missense_Mutation_p.E407K	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	484					gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						GACTCACACTCGGATTCACTG	0.378													T	31508865	T	T	31508865	3	4	243	1	0	0	0	0	1	0	0	0	13417	893	31	2	2782	2	RNASEN	5	31508865	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08		31508865	149406395	26	17325											
SLC30A5	64924	broad.mit.edu	37	chr5	68411085	68411085	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtggagtattattgctagtaCtggctttgtgttgtaaagtt	12	3	0	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr5:68411085C>G	uc003jvh.2	+	8	835	c.634C>G	c.(634-636)CTG>GTG	p.L212V	SLC30A5_uc003jvj.2_5'Flank|SLC30A5_uc003jvk.2_5'Flank|SLC30A5_uc003jvi.2_Missense_Mutation_p.L41V	NM_022902	NP_075053	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter),	212	Helical; (Potential).				cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		ATTGCTAGTACTGGCTTTGTG	0.373													G	68411085	G	G	68411085	3	3	243	1	0	0	0	0	1	0	0	0	14558	564	20	5	752	5	SLC30A5	5	68411085	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	36902220	68411085	112504175	27	17326											
PCDHA3	56145	broad.mit.edu	37	chr5	140180868	140180868	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcctcggaggtggggagcgGccagctccactactccgtct	14	14	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr5:140180868G>A	uc003lhf.2	+	1	86	c.86G>A	c.(85-87)GGC>GAC	p.G29D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.G29D	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	29					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGGGAGCGGCCAGCTCCAC	0.637													A	140180868	A	A	140180868	3	1	243	1	0	0	0	0	1	0	0	0	11525	1203	42	3	88	3	PCDHA3	5	140180868	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	71769783	140180868	40734392	28	17327											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720212	140720212	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgctggaccagaacgacaaCgcgcccgagatcctgtaccc	11	15	0	2	rs150000282	byFrequency	TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr5:140720212C>T	uc003ljk.1	+	1	1859	c.1674C>T	c.(1672-1674)AAC>AAT	p.N558N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.N558N	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	558	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAACGACAACGCGCCCGAGA	0.622													T	140720212	T	T	140720212	2	4	243	1	0	0	0	0	0	0	0	1	11554	535	19	1		1	PCDHGA2	5	140720212	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08	539344	140720212	40195048	29	17328											
TRIM26	7726	broad.mit.edu	37	chr6	30153775	30153775	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctctgcgttggtgaaagtcaCggtgcccccttcataatcca	9	13	3	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr6:30153775C>A	uc003npr.2	-	9	1707	c.1498G>T	c.(1498-1500)GTG>TTG	p.V500L	TRIM26_uc003nps.2_Missense_Mutation_p.V500L|TRIM26_uc010jry.2_Missense_Mutation_p.V230L|TRIM26_uc003npt.2_Missense_Mutation_p.V500L	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	500	B30.2/SPRY.						DNA binding|zinc ion binding			ovary(2)|lung(1)	3						GTGAAAGTCACGGTGCCCCCT	0.627													A	30153775	A	A	30153775	3	1	243	1	0	0	0	0	1	0	0	0	16497	536	19	5	125	5	TRIM26	6	30153775	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08		30153775	140961292	30	17329											
HLA-DPA1	3113	broad.mit.edu	37	chr6	33036842	33036842	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagccccagtgctccaccctGcagtcatagaagtcctctgc	8	16	2	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr6:33036842G>A	uc003ocs.1	-	3	613	c.582C>T	c.(580-582)TGC>TGT	p.C194C	HLA-DPA1_uc010juk.2_Silent_p.C194C|HLA-DPA1_uc003oct.1_Silent_p.C194C	NM_033554	NP_291032	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP	194	Alpha-2.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			skin(1)	1						GCTCCACCCTGCAGTCATAGA	0.537													A	33036842	A	A	33036842	2	1	243	1	0	0	0	0	0	0	0	1	7202	1311	46	3		3	HLA-DPA1	6	33036842	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08	2883067	33036842	138078225	31	17330											
FAM83B	222584	broad.mit.edu	37	chr6	54805390	54805390	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttatactcattctcggcttCgttcctctttagtatttaaa	4	9	3	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr6:54805390C>T	uc003pck.2	+	5	1737	c.1621C>T	c.(1621-1623)CGT>TGT	p.R541C		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	541				R -> S (in Ref. 4; BAB70873).						ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TTCTCGGCTTCGTTCCTCTTT	0.418													T	54805390	T	T	54805390	3	4	243	1	0	0	0	0	1	0	0	0	5634	884	31	2	1635	2	FAM83B	6	54805390	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	21768548	54805390	116309677	32	17331											
PRIM2	5558	broad.mit.edu	37	chr6	57498985	57498985	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agattttggatttagtaaagGggacacattaccaggtagcc	11	6	0	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr6:57498985G>C	uc003pdx.2	+	14	1336	c.1249G>C	c.(1249-1251)GGG>CGG	p.G417R		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	417					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TTTAGTAAAGGGGACACATTA	0.299													C	57498985	C	C	57498985	3	2	243	1	0	0	0	0	1	0	0	0	12491	1232	43	5	1295	5	PRIM2	6	57498985	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	2693595	57498985	113616082	33	17332											
AHR	196	broad.mit.edu	37	chr7	17375305	17375305	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagtggcatgatagttttccGgcttcttacaaaaaacaacc	7	9	1	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr7:17375305G>A	uc011jxz.1	+	9	1668	c.1055G>A	c.(1054-1056)CGG>CAG	p.R352Q	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	352	PAC.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					ATAGTTTTCCGGCTTCTTACA	0.333													A	17375305	A	A	17375305	3	1	243	1	0	0	0	0	1	0	0	0	416	1116	39	2	1089	2	AHR	7	17375305	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08		17375305	141763358	34	17333											
AOAH	313	broad.mit.edu	37	chr7	36571798	36571798	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgttggaagacatccagccGtggcaggggctgacctgaga	15	9	0	3			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr7:36571798G>A	uc003tfh.3	-	18	1781	c.1380C>T	c.(1378-1380)CAC>CAT	p.H460H	AOAH_uc010kxf.2_Silent_p.H460H|AOAH_uc011kba.1_Silent_p.H428H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	460					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						ACATCCAGCCGTGGCAGGGGC	0.512													A	36571798	A	A	36571798	2	1	243	1	0	0	0	0	0	0	0	1	726	1136	40	1		1	AOAH	7	36571798	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08	19196493	36571798	122566865	35	17334											
SMO	6608	broad.mit.edu	37	chr7	128843306	128843306	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccaagtgtgagaatgaccGggtggagctgcccagccgta	15	11	0	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr7:128843306G>A	uc003vor.2	+	2	693	c.413G>A	c.(412-414)CGG>CAG	p.R138Q		NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	138	FZ.|Extracellular (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						GAGAATGACCGGGTGGAGCTG	0.672			Mis		skin basal cell 								A	128843306	A	A	128843306	3	1	243	1	0	0	0	0	1	0	0	0	14800	1116	39	2	419	2	SMO	7	128843306	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	92271508	128843306	30295357	36	17335											
KEL	3792	broad.mit.edu	37	chr7	142639595	142639595	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacagtctccccatggtgccGtaacagcctcttgctgtatg	10	13	2	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr7:142639595G>A	uc003wcb.2	-	18	2173	c.1963C>T	c.(1963-1965)CGG>TGG	p.R655W		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	655	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					CCATGGTGCCGTAACAGCCTC	0.597													A	142639595	A	A	142639595	3	1	243	1	0	0	0	0	1	0	0	0	8142	1144	40	1	243	1	KEL	7	142639595	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	13796289	142639595	16499068	37	17336											
AGAP3	116988	broad.mit.edu	37	chr7	150835302	150835302	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctcggcctgggctggccCgcgccctgaggggctgcacc	16	17	0	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr7:150835302C>T	uc003wjg.1	+	12	1571	c.1568C>T	c.(1567-1569)CCG>CTG	p.P523L	AGAP3_uc003wje.1_Intron|AGAP3_uc003wjj.1_Intron|AGAP3_uc003wjk.1_5'Flank	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	487	PH.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						TGGGCTGGCCCGCGCCCTGAG	0.716													T	150835302	T	T	150835302	3	4	243	1	0	0	0	0	1	0	0	0	369	652	23	2	1681	2	AGAP3	7	150835302	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	8195707	150835302	8303361	38	17337											
NUB1	51667	broad.mit.edu	37	chr7	151065966	151065966	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccactcatattaccaaccGcagagaggtacccactttca	7	14	2	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr7:151065966G>A	uc003wjx.2	+	11	1318	c.1313G>A	c.(1312-1314)CGC>CAC	p.R438H	NUB1_uc003wjw.2_Missense_Mutation_p.R414H|NUB1_uc010lqc.2_RNA|uc003wjz.1_5'Flank	NM_016118	NP_057202	Q9Y5A7	NUB1_HUMAN	NEDD8 ultimate buster-1	414	Nuclear localization signal (Probable).				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		ATTACCAACCGCAGAGAGGTA	0.483													A	151065966	A	A	151065966	3	1	243	1	0	0	0	0	1	0	0	0	10714	1087	38	1	1279	1	NUB1	7	151065966	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	230664	151065966	8072697	39	17338											
CTSB	1508	broad.mit.edu	37	chr8	11706616	11706616	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccgacacctccacgctgaCgtgcgcattggtgtggatgc	13	14	0	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr8:11706616C>T	uc003wum.2	-	7	709	c.385G>A	c.(385-387)GTC>ATC	p.V129I	CTSB_uc003wul.2_5'Flank|CTSB_uc011kxl.1_Missense_Mutation_p.V50I|CTSB_uc003wun.2_Missense_Mutation_p.V129I|CTSB_uc003wuo.2_Missense_Mutation_p.V129I|CTSB_uc003wup.2_Missense_Mutation_p.V129I|CTSB_uc003wuq.2_Missense_Mutation_p.V129I|CTSB_uc010lsc.2_Intron|CTSB_uc003wur.2_Missense_Mutation_p.V129I|CTSB_uc003wus.1_Missense_Mutation_p.V129I|CTSB_uc003wut.1_Missense_Mutation_p.V129I|CTSB_uc003wuu.2_5'UTR	NM_147780	NP_680090	P07858	CATB_HUMAN	cathepsin B preproprotein	129					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity				0	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		TCCACGCTGACGTGCGCATTG	0.642													T	11706616	T	T	11706616	3	4	243	1	0	0	0	0	1	0	0	0	4030	536	19	1	658	1	CTSB	8	11706616	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08		11706616	134657406	40	17339											
FAM92A1	137392	broad.mit.edu	37	chr8	94713461	94713461	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttttccctaggaacgctcaAacgaaacaactgcaaacagc	6	13	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr8:94713461A>G	uc010maq.2	+	2	139	c.36A>G	c.(34-36)CAA>CAG	p.Q12Q	FAM92A1_uc003yfu.1_RNA|FAM92A1_uc003yfv.3_RNA	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	12											0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGAACGCTCAAACGAAACAAC	0.453													G	94713461	G	G	94713461	2	3	243	1	0	0	0	0	0	0	0	1	5652	11	1	4		4	FAM92A1	8	94713461	Silent	SNP	A	TCGA-41-2572-01A-01D-1353-08	83006845	94713461	51650561	41	17340											
PIGO	84720	broad.mit.edu	37	chr9	35092240	35092240	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aacagcaggagtaacaggacGggcccagggatgggaaacag	16	8	0	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr9:35092240G>T	uc003zwd.2	-	7	2040	c.1644C>A	c.(1642-1644)CCC>CCA	p.P548P	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Intron|PIGO_uc003zwf.2_Intron|PIGO_uc003zwg.1_Silent_p.P111P	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	548	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTAACAGGACGGGCCCAGGGA	0.577													T	35092240	T	T	35092240	2	4	243	1	0	0	0	0	0	0	0	1	11894	1103	39	5		5	PIGO	9	35092240	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08		35092240	106121191	42	17341											
RUSC2	9853	broad.mit.edu	37	chr9	35561054	35561054	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cagagcccaaggagagcctgCaggagccacactccccagcc	11	17	0	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr9:35561054C>G	uc003zww.2	+	11	4564	c.4309C>G	c.(4309-4311)CAG>GAG	p.Q1437E	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.Q1437E	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1437						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GGAGAGCCTGCAGGAGCCACA	0.657													G	35561054	G	G	35561054	3	3	243	1	0	0	0	0	1	0	0	0	13751	711	25	5	4347	5	RUSC2	9	35561054	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	468814	35561054	105652377	43	17342											
PHRF1	57661	broad.mit.edu	37	chr11	607162	607162	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agcactgccctccgggagccCggcccaaggcccgtcaggaa	13	17	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr11:607162C>A	uc001lqe.2	+	14	1837	c.1706C>A	c.(1705-1707)CCG>CAG	p.P569Q	PHRF1_uc010qwc.1_Missense_Mutation_p.P568Q|PHRF1_uc010qwd.1_Missense_Mutation_p.P567Q|PHRF1_uc010qwe.1_Missense_Mutation_p.P565Q|PHRF1_uc009ybz.1_Missense_Mutation_p.P359Q|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	569							RNA polymerase binding|zinc ion binding				0						TCCGGGAGCCCGGCCCAAGGC	0.662													A	607162	A	A	607162	3	1	243	1	0	0	0	0	1	0	0	0	11861	652	23	5	1753	5	PHRF1	11	607162	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08		607162	134399354	44	17343											
SLC3A2	6520	broad.mit.edu	37	chr11	62623803	62623803	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gattccgcgccagttgcctgGctcacattcggaggctggtg	14	12	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr11:62623803G>T	uc001nwd.2	+	1	286	c.62G>T	c.(61-63)GGC>GTC	p.G21V	SLC3A2_uc001nwb.2_Missense_Mutation_p.G21V|SLC3A2_uc001nwc.2_Missense_Mutation_p.G21V|SLC3A2_uc001nwe.2_Missense_Mutation_p.G21V|SLC3A2_uc001nwf.2_Missense_Mutation_p.G21V|SNHG1_uc001nvp.2_5'Flank|SNHG1_uc001nvo.2_5'Flank|SNHG1_uc001nvq.2_5'Flank|SNHG1_uc001nvs.2_5'Flank|SNHG1_uc001nvr.2_5'Flank|SNHG1_uc001nvt.2_5'Flank|SNHG1_uc001nvu.2_5'Flank|SNORD31_uc009yoj.1_5'Flank|SNORD30_uc001nvw.1_5'Flank|SNORD29_uc001nvx.2_5'Flank|SNORD28_uc001nvy.1_5'Flank|SNORD27_uc001nvz.2_5'Flank|SNORD26_uc009yok.1_5'Flank|SNORD25_uc001nwa.3_5'Flank	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	21					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						CAGTTGCCTGGCTCACATTCG	0.647													T	62623803	T	T	62623803	3	4	243	1	0	0	0	0	1	0	0	0	14627	1203	42	5	64	5	SLC3A2	11	62623803	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	62016641	62623803	72382713	45	17344											
P2RY2	5029	broad.mit.edu	37	chr11	72945627	72945627	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcttacgacctctgcgctcCctgcgctggggccgggcccg	14	17	2	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr11:72945627C>T	uc001otj.2	+	3	756	c.423C>T	c.(421-423)TCC>TCT	p.S141S	P2RY2_uc001otk.2_Silent_p.S141S|P2RY2_uc001otl.2_Silent_p.S141S	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	141	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	CTCTGCGCTCCCTGCGCTGGG	0.662													T	72945627	T	T	72945627	2	4	243	1	0	0	0	0	0	0	0	1	11352	610	22	3		3	P2RY2	11	72945627	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08	10321824	72945627	62060889	46	17345											
SNX19	399979	broad.mit.edu	37	chr11	130781567	130781567	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atctggtttctcctccagacGggtctgcagattcaagaact	9	11	4	3			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr11:130781567G>T	uc001qgk.3	-	2	2322	c.1774C>A	c.(1774-1776)CGT>AGT	p.R592S	SNX19_uc010sce.1_5'UTR|SNX19_uc010scf.1_Missense_Mutation_p.R35S|SNX19_uc010scg.1_5'UTR|SNX19_uc001qgl.3_Missense_Mutation_p.R592S|SNX19_uc009zcx.1_RNA	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	592	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		TCCTCCAGACGGGTCTGCAGA	0.557													T	130781567	T	T	130781567	3	4	243	1	0	0	0	0	1	0	0	0	14890	1116	39	5	1244	5	SNX19	11	130781567	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	57835940	130781567	4224949	47	17346											
WNT5B	81029	broad.mit.edu	37	chr12	1749108	1749108	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaggagcagggccgggtgcTcatgaacctgcaaaacaacg	14	10	1	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr12:1749108T>C	uc009zdq.2	+	4	829	c.587T>C	c.(586-588)CTC>CCC	p.L196P	WNT5B_uc001qjj.2_Missense_Mutation_p.L196P|WNT5B_uc001qjk.2_Missense_Mutation_p.L196P|WNT5B_uc001qjl.2_Missense_Mutation_p.L196P	NM_032642	NP_116031	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family,	196					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			GGCCGGGTGCTCATGAACCTG	0.632													C	1749108	C	C	1749108	3	2	243	1	0	0	0	0	1	0	0	0	17389	1551	54	4	597	4	WNT5B	12	1749108	Missense_Mutation	SNP	T	TCGA-41-2572-01A-01D-1353-08		1749108	132102787	48	17347											
FGD4	121512	broad.mit.edu	37	chr12	32791721	32791722	+	Frame_Shift_Ins	INS	-	C	C													tgtgctgtacatgtatggtgINSccccccaggtatctaaacca							TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr12:32791721_32791722insC	uc001rkz.2	+	16	2512_2513	c.2035_2036insC	c.(2035-2037)GCCfs	p.A679fs	FGD4_uc001rlc.2_Frame_Shift_Ins_p.A764fs|FGD4_uc001rky.2_Frame_Shift_Ins_p.A431fs|FGD4_uc001rla.2_Frame_Shift_Ins_p.A335fs|FGD4_uc010ske.1_Frame_Shift_Ins_p.A791fs|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	679	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					CATGTATGGTGCCCCCCAGGTA	0.505													C	32791722	C	C	32791721	7	5	243	1	0	1	1	0	0	0	0	0	5835	1319	46	0	2089	0	FGD4	12	32791721	Frame_Shift_Ins	INS	-	TCGA-41-2572-01A-01D-1353-08	31042613	32791721	101060174	49	17348											
OR8S1	341568	broad.mit.edu	37	chr12	48921845	48921845	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaaccccaaggggcctgcGcatgctccgcgctgcgcgcg	13	18	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr12:48921845G>A	uc010slu.1	+	2	1039	c.1039G>A	c.(1039-1041)GCA>ACA	p.A347T		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	347	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGGGGCCTGCGCATGCTCCGC	0.662													A	48921845	A	A	48921845	3	1	243	1	0	0	0	0	1	0	0	0	11246	1087	38	1	1045	1	OR8S1	12	48921845	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	16130124	48921845	84930050	50	17349											
SCYL2	55681	broad.mit.edu	37	chr12	100717360	100717360	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttatagactacccatccatgAaaaacgctttgataccaaga	5	10	0	4			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr12:100717360A>C	uc001thn.2	+	11	1503	c.1453A>C	c.(1453-1455)AAA>CAA	p.K485Q	SCYL2_uc009ztw.1_Missense_Mutation_p.K312Q|SCYL2_uc001thm.1_Missense_Mutation_p.K485Q	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	485					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						CCCATCCATGAAAAACGCTTT	0.318													C	100717360	C	C	100717360	3	2	243	1	0	0	0	0	1	0	0	0	13948	247	9	5	1491	5	SCYL2	12	100717360	Missense_Mutation	SNP	A	TCGA-41-2572-01A-01D-1353-08	51795515	100717360	33134535	51	17350											
ANO4	121601	broad.mit.edu	37	chr12	101520784	101520784	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatgaagcagaactggaacGtctccagaaggaacgaaagg	13	7	1	3	rs143188971	byFrequency	TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr12:101520784G>A	uc010svm.1	+	27	3376	c.2804G>A	c.(2803-2805)CGT>CAT	p.R935H	ANO4_uc001thw.2_Missense_Mutation_p.R900H|ANO4_uc001thx.2_Missense_Mutation_p.R935H|ANO4_uc001thy.2_Missense_Mutation_p.R455H	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	935	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GAACTGGAACGTCTCCAGAAG	0.483										HNSCC(74;0.22)			A	101520784	A	A	101520784	3	1	243	1	0	0	0	0	1	0	0	0	699	1145	40	1	2797	1	ANO4	12	101520784	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	803424	101520784	32331111	52	17351											
RYR3	6263	broad.mit.edu	37	chr15	33916210	33916210	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctctttcatcccatgccccGtagacaccagtcaggtaggt	8	15	3	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr15:33916210G>A	uc001zhi.2	+	20	2630	c.2560G>A	c.(2560-2562)GTA>ATA	p.V854I	RYR3_uc010bar.2_Missense_Mutation_p.V854I	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	854	4 X approximate repeats.|1.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCCATGCCCCGTAGACACCAG	0.433													A	33916210	A	A	33916210	3	1	243	1	0	0	0	0	1	0	0	0	13770	1145	40	1	2638	1	RYR3	15	33916210	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08		33916210	68615182	53	17352											
ACAN	176	broad.mit.edu	37	chr15	89389067	89389067	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcattcaccagtgaggacctCgtcgtgcaggtgaccgctgt	13	12	1	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr15:89389067C>T	uc010upo.1	+	7	1757	c.1383C>T	c.(1381-1383)CTC>CTT	p.L461L	ACAN_uc002bmx.2_Silent_p.L461L|ACAN_uc010upp.1_Silent_p.L461L|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	461					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GTGAGGACCTCGTCGTGCAGG	0.532													T	89389067	T	T	89389067	2	4	243	1	0	0	0	0	0	0	0	1	117	871	31	2		2	ACAN	15	89389067	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08	55472857	89389067	13142325	54	17353											
MVP	9961	broad.mit.edu	37	chr16	29858658	29858658	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagcagatgacagaggccatAggccccagcaccatcaggga	12	12	1	3			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr16:29858658A>G	uc002dui.2	+	14	2490	c.2406A>G	c.(2404-2406)ATA>ATG	p.I802M	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc002duj.2_Missense_Mutation_p.I802M|MVP_uc010vea.1_Missense_Mutation_p.I396M	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	802					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CAGAGGCCATAGGCCCCAGCA	0.582													G	29858658	G	G	29858658	3	3	243	1	0	0	0	0	1	0	0	0	9996	410	15	4	2456	4	MVP	16	29858658	Missense_Mutation	SNP	A	TCGA-41-2572-01A-01D-1353-08		29858658	60496095	55	17354											
ATP6V0D1	9114	broad.mit.edu	37	chr16	67477041	67477041	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgatctcgatgttcatctcGtcaaggtcctgctctgaaat	8	10	5	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr16:67477041G>A	uc002ete.1	-	4	622	c.522C>T	c.(520-522)GAC>GAT	p.D174D	ATP6V0D1_uc010vjo.1_Silent_p.D215D|ATP6V0D1_uc010vjn.1_Silent_p.D97D	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	174					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		TGTTCATCTCGTCAAGGTCCT	0.567													A	67477041	A	A	67477041	2	1	243	1	0	0	0	0	0	0	0	1	1173	1136	40	1		1	ATP6V0D1	16	67477041	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08	37618383	67477041	22877712	56	17355											
HYDIN	54768	broad.mit.edu	37	chr16	70908762	70908762	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctgtgatgtagatatacgCggtggtgggcctccctttca	12	10	2	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr16:70908762C>T	uc002ezr.2	-	63	10743	c.10615G>A	c.(10615-10617)GCG>ACG	p.A3539T		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3540										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TAGATATACGCGGTGGTGGGC	0.507													T	70908762	T	T	70908762	3	4	243	1	0	0	0	0	1	0	0	0	7467	768	27	1	4843	1	HYDIN	16	70908762	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	3431721	70908762	19445991	57	17356											
RABEP1	9135	broad.mit.edu	37	chr17	5235422	5235422	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agacagtggagagaagaagtTgcttcacttcaggctgttat	12	6	2	3			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr17:5235422T>G	uc002gbm.3	+	3	566	c.342T>G	c.(340-342)GTT>GTG	p.V114V	RABEP1_uc010clc.1_Silent_p.V114V|RABEP1_uc010cld.1_Silent_p.V71V|RABEP1_uc010vsw.1_Silent_p.V71V|RABEP1_uc002gbl.3_Silent_p.V114V|RABEP1_uc002gbj.2_Silent_p.V114V|RABEP1_uc002gbk.2_Silent_p.V114V	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	114	Potential.				apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2						GAGAAGAAGTTGCTTCACTTC	0.378													G	5235422	G	G	5235422	2	3	243	1	0	0	0	0	0	0	0	1	12961	1799	63	5		5	RABEP1	17	5235422	Silent	SNP	T	TCGA-41-2572-01A-01D-1353-08		5235422	75959788	58	17357											
MYH4	4622	broad.mit.edu	37	chr17	10358985	10358985	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggaagcctttcctgcagatgCggatgccttccagcacaccg	11	14	0	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr17:10358985C>A	uc002gmn.2	-	19	2231	c.2120G>T	c.(2119-2121)CGC>CTC	p.R707L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	707	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CCTGCAGATGCGGATGCCTTC	0.468													A	10358985	A	A	10358985	3	1	243	1	0	0	0	0	1	0	0	0	10037	768	27	5	3787	5	MYH4	17	10358985	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	5123563	10358985	70836225	59	17358											
MYH1	4619	broad.mit.edu	37	chr17	10408543	10408543	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctctgcacatggcctgggttCgggtaatcagctgggccagc	14	12	2	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr17:10408543C>T	uc002gmo.2	-	21	2466	c.2372G>A	c.(2371-2373)CGA>CAA	p.R791Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	791	IQ.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GGCCTGGGTTCGGGTAATCAG	0.458													T	10408543	T	T	10408543	3	4	243	1	0	0	0	0	1	0	0	0	10029	884	31	2	3527	2	MYH1	17	10408543	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	49558	10408543	70786667	60	17359											
USP22	23326	broad.mit.edu	37	chr17	20931977	20931977	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccacagacatggcagataCaggacttggcctgaaattca	10	11	1	3			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr17:20931977C>T	uc002gym.3	-	2	386	c.182G>A	c.(181-183)TGT>TAT	p.C61Y	USP22_uc002gyn.3_Missense_Mutation_p.C49Y|USP22_uc002gyl.3_5'UTR	NM_015276	NP_056091	Q9UPT9	UBP22_HUMAN	ubiquitin thiolesterase 22	61	UBP-type.				cell cycle|embryo development|histone deubiquitination|histone H4 acetylation|histone ubiquitination|positive regulation of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1						ATGGCAGATACAGGACTTGGC	0.517													T	20931977	T	T	20931977	3	4	243	1	0	0	0	0	1	0	0	0	17051	478	17	3	1443	3	USP22	17	20931977	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	10523434	20931977	60263233	61	17360											
C17orf70	80233	broad.mit.edu	37	chr17	79517665	79517665	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggctctgtcttcaaggccccTatgaagatgacgggctcctc	11	13	3	3			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr17:79517665T>C	uc002kaq.2	-	3	910	c.855A>G	c.(853-855)ATA>ATG	p.I285M	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Missense_Mutation_p.I134M	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	285					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			TCAAGGCCCCTATGAAGATGA	0.577													C	79517665	C	C	79517665	3	2	243	1	0	0	0	0	1	0	0	0	1877	1512	53	4	1818	4	C17orf70	17	79517665	Missense_Mutation	SNP	T	TCGA-41-2572-01A-01D-1353-08	58585688	79517665	1677545	62	17361											
LAMA1	284217	broad.mit.edu	37	chr18	7034562	7034562	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggacagtcatcagctggtcaCgatcaatctgccttttgctg	10	11	5	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr18:7034562C>T	uc002knm.2	-	14	2061	c.1967G>A	c.(1966-1968)CGT>CAT	p.R656H	LAMA1_uc010wzj.1_Missense_Mutation_p.R132H	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	656	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGCTGGTCACGATCAATCTG	0.423													T	7034562	T	T	7034562	3	4	243	1	0	0	0	0	1	0	0	0	8605	536	19	1	7460	1	LAMA1	18	7034562	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08		7034562	71042686	63	17362											
SERPINB7	8710	broad.mit.edu	37	chr18	61465969	61465969	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaccataaattgccatttcAaatctcccaaggtatgtcgt	5	10	2	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr18:61465969A>G	uc002ljl.2	+	6	682	c.586A>G	c.(586-588)AAA>GAA	p.K196E	SERPINB7_uc002ljm.2_Missense_Mutation_p.K196E|SERPINB7_uc010xet.1_Missense_Mutation_p.K179E|SERPINB7_uc010dqg.2_Missense_Mutation_p.K196E	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	196					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				TTGCCATTTCAAATCTCCCAA	0.403													G	61465969	G	G	61465969	3	3	243	1	0	0	0	0	1	0	0	0	14106	131	5	4	604	4	SERPINB7	18	61465969	Missense_Mutation	SNP	A	TCGA-41-2572-01A-01D-1353-08	54431407	61465969	16611279	64	17363											
PALM	5064	broad.mit.edu	37	chr19	746493	746493	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgtgcaggcacagccaggCgaggccacgtccggcccgcc	16	16	0	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:746493C>T	uc002lpm.1	+	9	1037	c.843C>T	c.(841-843)GGC>GGT	p.G281G	PALM_uc002lpn.1_Silent_p.G237G|PALM_uc010xfu.1_Silent_p.G146G	NM_002579	NP_002570	O75781	PALM_HUMAN	paralemmin isoform 1	281					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		CACAGCCAGGCGAGGCCACGT	0.726													T	746493	T	T	746493	2	4	243	1	0	0	0	0	0	0	0	1	11408	755	27	1		1	PALM	19	746493	Silent	SNP	C	TCGA-41-2572-01A-01D-1353-08		746493	58382490	65	17364											
CD97	976	broad.mit.edu	37	chr19	14513618	14513618	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaactcccccatccttttcGccttctcccaccttgagtcc	3	20	2	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:14513618G>A	uc002myl.2	+	12	1516	c.1393G>A	c.(1393-1395)GCC>ACC	p.A465T	CD97_uc002mym.2_Missense_Mutation_p.A416T|CD97_uc002myn.2_Missense_Mutation_p.A372T	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	465	Extracellular (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						CATCCTTTTCGCCTTCTCCCA	0.527													A	14513618	A	A	14513618	3	1	243	1	0	0	0	0	1	0	0	0	3049	1087	38	1	1439	1	CD97	19	14513618	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	13767125	14513618	44615365	66	17365											
FAM32A	26017	broad.mit.edu	37	chr19	16301334	16301334	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtctcttctctctccagcaaAtggaaaggatcctaaagaag	8	10	3	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:16301334A>G	uc002ndt.2	+	3	239	c.220A>G	c.(220-222)ATG>GTG	p.M74V		NM_014077	NP_054796	Q9Y421	FA32A_HUMAN	hypothetical protein LOC26017	74	Lys-rich.					nucleolus					0						TCTCCAGCAAATGGAAAGGAT	0.562													G	16301334	G	G	16301334	3	3	243	1	0	0	0	0	1	0	0	0	5552	101	4	4	230	4	FAM32A	19	16301334	Missense_Mutation	SNP	A	TCGA-41-2572-01A-01D-1353-08	1787716	16301334	42827649	67	17366											
CD22	933	broad.mit.edu	37	chr19	35832290	35832290	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggaaaatcaagcccctttccGagattcactctggaaactcg	8	12	3	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:35832290G>A	uc010edt.2	+	8	1629	c.1552G>A	c.(1552-1554)GAG>AAG	p.E518K	CD22_uc010xst.1_Missense_Mutation_p.E346K|CD22_uc010edu.2_Missense_Mutation_p.E430K|CD22_uc010edv.2_Missense_Mutation_p.E518K|CD22_uc002nzb.3_Missense_Mutation_p.E341K|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	518	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GCCCCTTTCCGAGATTCACTC	0.572													A	35832290	A	A	35832290	3	1	243	1	0	0	0	0	1	0	0	0	2985	1059	37	2	1578	2	CD22	19	35832290	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	19530956	35832290	23296693	68	17367											
HKR1	284459	broad.mit.edu	37	chr19	37853831	37853831	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcattacccaccagagggcGcacactggggagaagcctta	11	13	1	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:37853831G>A	uc002ogb.2	+	6	1403	c.1134G>A	c.(1132-1134)GCG>GCA	p.A378A	HKR1_uc002ofx.2_Silent_p.A94A|HKR1_uc002ofy.2_Silent_p.A94A|HKR1_uc002oga.2_Silent_p.A360A|HKR1_uc010xto.1_Silent_p.A360A|HKR1_uc002ogc.2_Silent_p.A359A|HKR1_uc010xtp.1_Silent_p.A317A|HKR1_uc002ogd.2_Silent_p.A317A	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	378	C2H2-type 3.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACCAGAGGGCGCACACTGGGG	0.532													A	37853831	A	A	37853831	2	1	243	1	0	0	0	0	0	0	0	1	7194	1074	38	1		1	HKR1	19	37853831	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08	2021541	37853831	21275152	69	17368											
ACPT	93650	broad.mit.edu	37	chr19	51295361	51295361	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccccatgcgcagctgtccccGataccacgagctgctgcggg	12	17	0	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:51295361G>A	uc002pta.1	+	5	482	c.482G>A	c.(481-483)CGA>CAA	p.R161Q		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	161	Extracellular (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		AGCTGTCCCCGATACCACGAG	0.468													A	51295361	A	A	51295361	3	1	243	1	0	0	0	0	1	0	0	0	168	1058	37	2	500	2	ACPT	19	51295361	Missense_Mutation	SNP	G	TCGA-41-2572-01A-01D-1353-08	13441530	51295361	7833622	70	17369											
BIRC8	112401	broad.mit.edu	37	chr19	53794413	53794413	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatataggacttgtccaccGtctcgcgccaggatagcggc	12	12	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:53794413G>A	uc002qbk.2	-	1	463	c.-785C>T	c.(-787--783)GACGG>GATGG			NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8						apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		CTTGTCCACCGTCTCGCGCCA	0.527													A	53794413	A	A	53794413	1	1	243	1	0	0	0	0	0	0	0	0	1440	1160	40	1		1	BIRC8	19	53794413	Translation_Start_Site	SNP	G	TCGA-41-2572-01A-01D-1353-08	2499052	53794413	5334570	71	17370											
LILRB2	10288	broad.mit.edu	37	chr19	54784355	54784355	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgacgatgggggtcatggcGtctcctcccactgccctgct	13	14	2	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:54784355G>A	uc002qfb.2	-	2	263	c.-3C>T	c.(-5--1)GACGC>GATGC		LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Translation_Start_Site|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Translation_Start_Site|LILRB2_uc010yet.1_Translation_Start_Site|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,						cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGTCATGGCGTCTCCTCCCA	0.592													A	54784355	A	A	54784355	1	1	243	1	0	0	0	0	0	0	0	0	8791	1160	40	1		1	LILRB2	19	54784355	Translation_Start_Site	SNP	G	TCGA-41-2572-01A-01D-1353-08	989942	54784355	4344628	72	17371											
HSPBP1	23640	broad.mit.edu	37	chr19	55776732	55776732	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggctcccgacactcgcgcaCaccctgcggaaagtctgtca	10	17	2	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:55776732C>T	uc002qjx.2	-	6	1167	c.1057G>A	c.(1057-1059)GTG>ATG	p.V353M	HSPBP1_uc002qjy.2_Missense_Mutation_p.V307M|HSPBP1_uc002qkb.2_Missense_Mutation_p.C303Y|HSPBP1_uc002qka.2_Missense_Mutation_p.V307M|HSPBP1_uc002qkd.2_Missense_Mutation_p.V307M|HSPBP1_uc002qkc.2_Missense_Mutation_p.V307M|uc002qke.2_5'Flank	NM_012267	NP_036399	Q9NZL4	HPBP1_HUMAN	hsp70-interacting protein	310					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CACTCGCGCACACCCTGCGGA	0.612													T	55776732	T	T	55776732	3	4	243	1	0	0	0	0	1	0	0	0	7426	478	17	3	168	3	HSPBP1	19	55776732	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	992377	55776732	3352251	73	17372											
HSPBP1	23640	broad.mit.edu	37	chr19	55777302	55777302	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaggggctgtgctctgtcCgcaccagggccaccagctgc	15	14	1	0			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:55777302C>T	uc002qjx.2	-	5	1093	c.983G>A	c.(982-984)CGG>CAG	p.R328Q	HSPBP1_uc002qjy.2_Missense_Mutation_p.R282Q|HSPBP1_uc002qkb.2_Missense_Mutation_p.R282Q|HSPBP1_uc002qka.2_Missense_Mutation_p.R282Q|HSPBP1_uc002qkd.2_Missense_Mutation_p.R282Q|HSPBP1_uc002qkc.2_Missense_Mutation_p.R282Q|uc002qke.2_5'Flank	NM_012267	NP_036399	Q9NZL4	HPBP1_HUMAN	hsp70-interacting protein	285	ARM 4.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GTGCTCTGTCCGCACCAGGGC	0.687													T	55777302	T	T	55777302	3	4	243	1	0	0	0	0	1	0	0	0	7426	652	23	2	246	2	HSPBP1	19	55777302	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	570	55777302	3351681	74	17373											
ZSCAN1	284312	broad.mit.edu	37	chr19	58564905	58564905	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggactgtgatctcgagccCcaagggtccaagtgctcaga	13	11	2	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr19:58564905C>T	uc002qrc.1	+	6	960	c.713C>T	c.(712-714)CCC>CTC	p.P238L		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	238					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		ATCTCGAGCCCCAAGGGTCCA	0.617													T	58564905	T	T	58564905	3	4	243	1	0	0	0	0	1	0	0	0	18223	623	22	3	727	3	ZSCAN1	19	58564905	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	2787603	58564905	564078	75	17374											
MYBL2	4605	broad.mit.edu	37	chr20	42331498	42331498	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gattcctgtaacagcctcacGcccaagagcacacctgttaa	7	14	1	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr20:42331498G>A	uc002xlb.1	+	8	1535	c.1320G>A	c.(1318-1320)ACG>ACA	p.T440T	MYBL2_uc010zwj.1_Silent_p.T416T|MYBL2_uc002xla.1_Silent_p.T440T	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	440						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACAGCCTCACGCCCAAGAGCA	0.542													A	42331498	A	A	42331498	2	1	243	1	0	0	0	0	0	0	0	1	10010	1074	38	1		1	MYBL2	20	42331498	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08		42331498	20694022	76	17375											
CCT8L2	150160	broad.mit.edu	37	chr22	17072504	17072504	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacctagcttgaatcaccaCgatgccatacttgtccgcca	7	14	1	2			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chr22:17072504C>T	uc002zlp.1	-	1	1197	c.937G>A	c.(937-939)GTG>ATG	p.V313M		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	313					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGAATCACCACGATGCCATAC	0.557													T	17072504	T	T	17072504	3	4	243	1	0	0	0	0	1	0	0	0	2961	536	19	1	740	1	CCT8L2	22	17072504	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08		17072504	34232062	77	17376											
P2RY8	286530	broad.mit.edu	37	chrX	1584669	1584669	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgtagaacaggcggctcacGatgtgcgccaggagcacgaa	14	12	1	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chrX:1584669G>A	uc004cpz.2	-	2	1031	c.783C>T	c.(781-783)ATC>ATT	p.I261I		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	261	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCGGCTCACGATGTGCGCCA	0.612			T	CRLF2	B-ALL|Downs associated ALL								A	1584669	A	A	1584669	2	1	243	1	0	0	0	0	0	0	0	1	11355	1048	37	2		2	P2RY8	23	1584669	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08		1584669	153685891	78	17377											
GSPT2	23708	broad.mit.edu	37	chrX	51487887	51487887	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaggacattcactttatgCcctgctcaggactgaccgga	9	11	2	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chrX:51487887C>T	uc004dpl.2	+	1	1391	c.1165C>T	c.(1165-1167)CCC>TCC	p.P389S		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	389					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					TCACTTTATGCCCTGCTCAGG	0.393													T	51487887	T	T	51487887	3	4	243	1	0	0	0	0	1	0	0	0	6827	739	26	3	1167	3	GSPT2	23	51487887	Missense_Mutation	SNP	C	TCGA-41-2572-01A-01D-1353-08	49903218	51487887	103782673	79	17378											
PFKFB1	5207	broad.mit.edu	37	chrX	54986328	54986328	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggctgccagggcgcactgccTgaaatagaccaggaaagaaa	13	10	0	3			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chrX:54986328T>C	uc004dty.1	-	4	389	c.318_splice	c.e4-1	p.K106_splice	PFKFB1_uc010nkd.1_Splice_Site_p.K92_splice|PFKFB1_uc011mol.1_Splice_Site_p.K41_splice	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,						energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						GCGCACTGCCTGAAATAGACC	0.443													C	54986328	C	C	54986328	5	2	243	1	0	0	0	0	0	0	1	0	11760	1594	55	4	1143	4	PFKFB1	23	54986328	Splice_Site	SNP	T	TCGA-41-2572-01A-01D-1353-08	3498441	54986328	100284232	80	17379											
IL13RA2	3598	broad.mit.edu	37	chrX	114248418	114248418	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tattgccaattgtaatatacGcaatccatatcctgaacttt	4	9	0	1			TCGA-41-2572-01A-01D-1353-08	TCGA-41-2572-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	66384543-cff1-44f0-9920-9abe126ca32e	4d73babf-b967-4617-9050-48ddebf9c0d4	g.chrX:114248418G>A	uc004epx.2	-	5	560	c.435C>T	c.(433-435)TGC>TGT	p.C145C	IL13RA2_uc010nqd.1_Silent_p.C145C	NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	145	Extracellular (Potential).|Fibronectin type-III 2.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3						TGTAATATACGCAATCCATAT	0.328													A	114248418	A	A	114248418	2	1	243	1	0	0	0	0	0	0	0	1	7630	1079	38	1		1	IL13RA2	23	114248418	Silent	SNP	G	TCGA-41-2572-01A-01D-1353-08	59262090	114248418	41022142	81	17380											
PRAMEF1	65121	broad.mit.edu	37	chr1	12854536	12854536	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagataatgaactccaaggaCggttagttgccaaattcagc	9	9	1	2	rs1063777		TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr1:12854536C>T	uc001auj.1	+	3	863	c.760C>T	c.(760-762)CGG>TGG	p.R254W		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	254											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACTCCAAGGACGGTTAGTTGC	0.438													T	12854536	T	T	12854536	3	4	244	1	0	0	0	0	1	0	0	0	12425	527	19	1	766	1	PRAMEF1	1	12854536	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08		12854536	236396085	1	17381											
KIF17	57576	broad.mit.edu	37	chr1	21016727	21016727	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcgtggacagcctgacgtcAtatgagttgcgcatggcagt	14	9	1	2	rs143130602		TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr1:21016727A>G	uc001bdr.3	-	7	1453	c.1335T>C	c.(1333-1335)TAT>TAC	p.Y445Y	KIF17_uc009vpx.2_Missense_Mutation_p.M1T|KIF17_uc001bds.3_Silent_p.Y445Y	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	445	Potential.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GCCTGACGTCATATGAGTTGC	0.627													G	21016727	G	G	21016727	2	3	244	1	0	0	0	0	0	0	0	1	8279	224	8	4		4	KIF17	1	21016727	Silent	SNP	A	TCGA-41-2573-01A-01D-1495-08	8162191	21016727	228233894	2	17382											
SLC44A5	204962	broad.mit.edu	37	chr1	75708631	75708631	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcttcccagtagcttttgtcTtttgtgtacaaaagttgcat	7	8	2	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr1:75708631T>A	uc001dgu.2	-	8	555	c.411A>T	c.(409-411)AAA>AAT	p.K137N	SLC44A5_uc001dgt.2_Missense_Mutation_p.K137N|SLC44A5_uc001dgs.2_Missense_Mutation_p.K95N|SLC44A5_uc001dgr.2_Missense_Mutation_p.K95N|SLC44A5_uc010oqz.1_Missense_Mutation_p.K176N|SLC44A5_uc010ora.1_Missense_Mutation_p.K131N|SLC44A5_uc010orb.1_Missense_Mutation_p.K7N	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	137	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						AGCTTTTGTCTTTTGTGTACA	0.393													A	75708631	A	A	75708631	3	1	244	1	0	0	0	0	1	0	0	0	14639	1606	56	5	1927	5	SLC44A5	1	75708631	Missense_Mutation	SNP	T	TCGA-41-2573-01A-01D-1495-08	54691904	75708631	173541990	3	17383											
PLA2G4A	5321	broad.mit.edu	37	chr1	186863259	186863259	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggatgccaattatgtcatGgatgaaactctagggacagc	11	7	2	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr1:186863259G>A	uc001gsc.2	+	5	499	c.294G>A	c.(292-294)ATG>ATA	p.M98I	PLA2G4A_uc010pos.1_Missense_Mutation_p.M98I	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	98	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	ATTATGTCATGGATGAAACTC	0.338													A	186863259	A	A	186863259	3	1	244	1	0	0	0	0	1	0	0	0	12001	1348	47	3	308	3	PLA2G4A	1	186863259	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	111154628	186863259	62387362	4	17384											
RYR2	6262	broad.mit.edu	37	chr1	237632425	237632425	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggaaatcgtaaaaactgtgCtcaattttctggctccctcg	8	10	2	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr1:237632425C>G	uc001hyl.1	+	17	1766	c.1646C>G	c.(1645-1647)GCT>GGT	p.A549G		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	549	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAAAACTGTGCTCAATTTTCT	0.373													G	237632425	G	G	237632425	3	3	244	1	0	0	0	0	1	0	0	0	13769	797	28	5	1712	5	RYR2	1	237632425	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	50769166	237632425	11618196	5	17385											
NBAS	51594	broad.mit.edu	37	chr2	15564456	15564456	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cacctgccgagcataatgctCtatttcctctgctctggtct	7	14	4	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr2:15564456C>G	uc002rcc.1	-	23	2586	c.2560G>C	c.(2560-2562)GAG>CAG	p.E854Q	NBAS_uc010exl.1_Missense_Mutation_p.E46Q|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	854										ovary(2)|liver(1)|skin(1)	4						GCATAATGCTCTATTTCCTCT	0.502													G	15564456	G	G	15564456	3	3	244	1	0	0	0	0	1	0	0	0	10186	922	32	5	4675	5	NBAS	2	15564456	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08		15564456	227634917	6	17386											
XDH	7498	broad.mit.edu	37	chr2	31588885	31588885	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtggacaccacagtgctccGggtctccttgcctccaaagc	10	16	1	0	rs140007233		TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr2:31588885G>A	uc002rnv.1	-	22	2492	c.2413C>T	c.(2413-2415)CGG>TGG	p.R805W		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	805					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	ACAGTGCTCCGGGTCTCCTTG	0.527													A	31588885	A	A	31588885	3	1	244	1	0	0	0	0	1	0	0	0	17423	1115	39	2	1648	2	XDH	2	31588885	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	16024429	31588885	211610488	7	17387											
DQX1	165545	broad.mit.edu	37	chr2	74747143	74747143	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctgcactgagtggaggaCgggtaaacccaggggcagct	15	10	1	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr2:74747143C>T	uc010yrw.1	-	9	1679	c.1514G>A	c.(1513-1515)CGT>CAT	p.R505H	DQX1_uc002smc.2_Missense_Mutation_p.R66H	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	505						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						GAGTGGAGGACGGGTAAACCC	0.527													T	74747143	T	T	74747143	3	4	244	1	0	0	0	0	1	0	0	0	4751	536	19	1	655	1	DQX1	2	74747143	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	43158258	74747143	168452230	8	17388											
OSBPL10	114884	broad.mit.edu	37	chr3	31921180	31921180	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catctctccattagcagagtAcaccaccagcatgtggggag	10	12	1	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr3:31921180A>G	uc003cev.2	-	3	805	c.424T>C	c.(424-426)TAC>CAC	p.Y142H	OSBPL10_uc011axf.1_Missense_Mutation_p.Y142H	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	142	PH.				lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)		TTAGCAGAGTACACCACCAGC	0.483													G	31921180	G	G	31921180	3	3	244	1	0	0	0	0	1	0	0	0	11275	391	14	4	1914	4	OSBPL10	3	31921180	Missense_Mutation	SNP	A	TCGA-41-2573-01A-01D-1495-08		31921180	166101250	9	17389											
IMPDH2	3615	broad.mit.edu	37	chr3	49064276	49064276	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttcaggtctgtccgggcaatGatggccacaagctcatcatc	10	12	4	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr3:49064276G>A	uc003cvt.2	-	7	755	c.663C>T	c.(661-663)ATC>ATT	p.I221I		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	221	CBS 2.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	TCCGGGCAATGATGGCCACAA	0.527													A	49064276	A	A	49064276	2	1	244	1	0	0	0	0	0	0	0	1	7727	1280	45	3		3	IMPDH2	3	49064276	Silent	SNP	G	TCGA-41-2573-01A-01D-1495-08	17143096	49064276	148958154	10	17390											
HCLS1	3059	broad.mit.edu	37	chr3	121351248	121351248	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atagtccccctctggttcatCctcctgctcatgcctgtcca	6	17	3	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr3:121351248C>T	uc003eeh.3	-	12	1296	c.1171G>A	c.(1171-1173)GAT>AAT	p.D391N	HCLS1_uc011bjj.1_Missense_Mutation_p.D354N|HCLS1_uc011bjk.1_RNA	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	391					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		TCTGGTTCATCCTCCTGCTCA	0.413													T	121351248	T	T	121351248	3	4	244	1	0	0	0	0	1	0	0	0	6995	855	30	3	301	3	HCLS1	3	121351248	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	72286972	121351248	76671182	11	17391											
LEKR1	389170	broad.mit.edu	37	chr3	156763431	156763431	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgaagagggttagatcaggCgtgcccattctcccccagcc	11	15	2	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr3:156763431C>T	uc003fba.1	+	14	2394	c.1059C>T	c.(1057-1059)GGC>GGT	p.G353G		NM_001004316	NP_001004316	Q6ZMV7	LEKR1_HUMAN	leucine, glutamate and lysine rich 1	Error:Variant_position_missing_in_D3DNK7_after_alignment											0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TTAGATCAGGCGTGCCCATTC	0.537													T	156763431	T	T	156763431	2	4	244	1	0	0	0	0	0	0	0	1	8717	755	27	1		1	LEKR1	3	156763431	Silent	SNP	C	TCGA-41-2573-01A-01D-1495-08	35412183	156763431	41258999	12	17392											
ZNF595	152687	broad.mit.edu	37	chr4	60030	60030	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aatttgaagatacatgagacAgcagccaaacccccaggtag	9	10	0	3			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr4:60030A>T	uc003fzv.1	+	3	366	c.210A>T	c.(208-210)ACA>ACT	p.T70T	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Silent_p.T70T|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_Intron|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	70					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TACATGAGACAGCAGCCAAAC	0.468													T	60030	T	T	60030	2	4	244	1	0	0	0	0	0	0	0	1	18022	175	7	5		5	ZNF595	4	60030	Silent	SNP	A	TCGA-41-2573-01A-01D-1495-08		60030	191094246	13	17393											
UGT2A3	79799	broad.mit.edu	37	chr4	69795704	69795704	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agctgatcgcaggtgcttggCtcctttgtggcgcatgacaa	13	10	0	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr4:69795704C>A	uc003hef.2	-	6	1442	c.1411G>T	c.(1411-1413)GCC>TCC	p.A471S	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	471	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						AGGTGCTTGGCTCCTTTGTGG	0.488													A	69795704	A	A	69795704	3	1	244	1	0	0	0	0	1	0	0	0	16952	797	28	5	176	5	UGT2A3	4	69795704	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	69735674	69795704	121358572	14	17394											
HSPB3	8988	broad.mit.edu	37	chr5	53751481	53751481	+	Translation_Start_Site	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcaggcctaattaagtgatTgcgtctgggcacggctataa	11	8	2	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr5:53751481T>G	uc003jph.1	+	1	37	c.-138T>G	c.(-140--136)ATTGC>ATGGC			NM_006308	NP_006299	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3						cell death|response to heat|response to unfolded protein	cytoplasm|nucleus					0		Lung NSC(810;0.00104)				ATTAAGTGATTGCGTCTGGGC	0.488													G	53751481	G	G	53751481	1	3	244	1	0	0	0	0	0	0	0	0	7421	1827	63	5		5	HSPB3	5	53751481	Translation_Start_Site	SNP	T	TCGA-41-2573-01A-01D-1495-08		53751481	127163779	15	17395											
MAP3K1	4214	broad.mit.edu	37	chr5	56179395	56179395	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cataccaaagcaaaacaaccGtatagagaagacactgaatg	7	9	0	3			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr5:56179395G>A	uc003jqw.3	+	15	4209	c.3708G>A	c.(3706-3708)CCG>CCA	p.P1236P		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	1236					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		CAAAACAACCGTATAGAGAAG	0.383													A	56179395	A	A	56179395	2	1	244	1	0	0	0	0	0	0	0	1	9243	1132	40	1		1	MAP3K1	5	56179395	Silent	SNP	G	TCGA-41-2573-01A-01D-1495-08	2427914	56179395	124735865	16	17396											
GPR98	84059	broad.mit.edu	37	chr5	89985863	89985863	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cagaggcagtcattattattGaggcctctgatgacccctat	9	10	2	4			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr5:89985863G>C	uc003kju.2	+	30	6772	c.6676G>C	c.(6676-6678)GAG>CAG	p.E2226Q	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2226	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CATTATTATTGAGGCCTCTGA	0.378													C	89985863	C	C	89985863	3	2	244	1	0	0	0	0	1	0	0	0	6721	1291	45	5	6794	5	GPR98	5	89985863	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	33806468	89985863	90929397	17	17397											
FTMT	94033	broad.mit.edu	37	chr5	121187869	121187869	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcccctctcgggtgcgccagAacttccaccccgactccgag	10	19	1	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr5:121187869A>G	uc003kss.2	+	1	220	c.211A>G	c.(211-213)AAC>GAC	p.N71D		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	71	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GGTGCGCCAGAACTTCCACCC	0.692													G	121187869	G	G	121187869	3	3	244	1	0	0	0	0	1	0	0	0	6085	246	9	4	213	4	FTMT	5	121187869	Missense_Mutation	SNP	A	TCGA-41-2573-01A-01D-1495-08	31202006	121187869	59727391	18	17398											
KCNMB1	3779	broad.mit.edu	37	chr5	169805757	169805757	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggttgctcttcaccatgGcgataatgaggaggccaccg	12	11	2	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr5:169805757G>A	uc003maq.1	-	4	927	c.527C>T	c.(526-528)GCC>GTC	p.A176V	KCNIP1_uc003map.2_Intron	NM_004137	NP_004128	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated	176	Helical; Name=2; (Potential).				platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			ovary(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		CTTCACCATGGCGATAATGAG	0.612													A	169805757	A	A	169805757	3	1	244	1	0	0	0	0	1	0	0	0	8074	1203	42	3	52	3	KCNMB1	5	169805757	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	48617888	169805757	11109503	19	17399											
DSP	1832	broad.mit.edu	37	chr6	7581800	7581800	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aattccaaaagcaggctttaGaggtattcacaaatacttga	7	7	1	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr6:7581800G>A	uc003mxp.1	+	23	5656	c.5377G>A	c.(5377-5379)GAG>AAG	p.E1793K	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1793	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCAGGCTTTAGAGGTATTCAC	0.383													A	7581800	A	A	7581800	3	1	244	1	0	0	0	0	1	0	0	0	4781	943	33	3	5467	3	DSP	6	7581800	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08		7581800	163533267	20	17400											
MAS1L	116511	broad.mit.edu	37	chr6	29455047	29455047	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acatgtttccagtaagttagGaaaagtgattttactatgtt	8	4	0	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr6:29455047G>A	uc011dlq.1	-	1	633	c.633C>T	c.(631-633)TTC>TTT	p.F211F		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	211	Extracellular (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						AGTAAGTTAGGAAAAGTGATT	0.433													A	29455047	A	A	29455047	2	1	244	1	0	0	0	0	0	0	0	1	9321	1165	41	3		3	MAS1L	6	29455047	Silent	SNP	G	TCGA-41-2573-01A-01D-1495-08	21873247	29455047	141660020	21	17401											
MDN1	23195	broad.mit.edu	37	chr6	90360511	90360511	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gctcttcacataaccgttgtGaaagaggcgctgttaagatc	10	9	2	3			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr6:90360511G>A	uc003pnn.1	-	96	16087	c.15971C>T	c.(15970-15972)TCA>TTA	p.S5324L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5324					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TAACCGTTGTGAAAGAGGCGC	0.493													A	90360511	A	A	90360511	3	1	244	1	0	0	0	0	1	0	0	0	9415	1294	45	3	847	3	MDN1	6	90360511	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	60905464	90360511	80754556	22	17402											
TMEM200A	114801	broad.mit.edu	37	chr6	130762228	130762228	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cgggttttcggagcagttttCgaatggacagctccgtggag	15	8	0	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr6:130762228C>T	uc003qca.2	+	3	1532	c.661C>T	c.(661-663)CGA>TGA	p.R221*	TMEM200A_uc010kfh.2_Nonsense_Mutation_p.R221*|TMEM200A_uc010kfi.2_Nonsense_Mutation_p.R221*|TMEM200A_uc003qcb.2_Nonsense_Mutation_p.R221*	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	221	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GAGCAGTTTTCGAATGGACAG	0.478													T	130762228	T	T	130762228	4	4	244	1	0	0	0	0	0	1	0	0	16120	876	31	2	663	2	TMEM200A	6	130762228	Nonsense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	40401717	130762228	40352839	23	17403											
SRCRB4D	136853	broad.mit.edu	37	chr7	76033672	76033672	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcttgggggaggaagggagGggcagcactcccatctccca	17	11	1	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr7:76033672G>A	uc003ufb.2	-	2	433	c.85C>T	c.(85-87)CCT>TCT	p.P29S	ZP3_uc003ufc.3_Intron	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	29						extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						AGGAAGGGAGGGGCAGCACTC	0.507													A	76033672	A	A	76033672	3	1	244	1	0	0	0	0	1	0	0	0	15136	1232	43	3	1682	3	SRCRB4D	7	76033672	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08		76033672	83104991	24	17404											
AKR1B15	441282	broad.mit.edu	37	chr7	134254273	134254273	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcttattcactggccacagGgattcaaggtttgagtgact	10	8	3	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr7:134254273G>A	uc011kpr.1	+	5	726	c.427G>A	c.(427-429)GGA>AGA	p.G143R	AKR1B15_uc003vrt.2_Missense_Mutation_p.G115R|AKR1B15_uc011kps.1_Missense_Mutation_p.G115R	NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	143							oxidoreductase activity			ovary(1)	1						CTGGCCACAGGGATTCAAGGT	0.358													A	134254273	A	A	134254273	3	1	244	1	0	0	0	0	1	0	0	0	468	1233	43	3	437	3	AKR1B15	7	134254273	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	58220601	134254273	24884390	25	17405											
ZC3HAV1	56829	broad.mit.edu	37	chr7	138794019	138794019	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagcgcgtccagggccatgCggcccccgtgggcgcacagg	17	16	0	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr7:138794019C>T	uc003vun.2	-	1	447	c.59G>A	c.(58-60)CGC>CAC	p.R20H	ZC3HAV1_uc003vup.2_Missense_Mutation_p.R20H	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	20					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						CAGGGCCATGCGGCCCCCGTG	0.701													T	138794019	T	T	138794019	3	4	244	1	0	0	0	0	1	0	0	0	17572	768	27	1	2705	1	ZC3HAV1	7	138794019	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	4539746	138794019	20344644	26	17406											
PRSS1	5644	broad.mit.edu	37	chr7	142459677	142459677	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tcgaagtcctggaggggaatGagcagttcatcaatgcagcc	13	9	2	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr7:142459677G>A	uc003wak.2	+	3	270	c.253G>A	c.(253-255)GAG>AAG	p.E85K	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.E25K	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	85	Peptidase S1.	Calcium.			digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GGAGGGGAATGAGCAGTTCAT	0.547									Hereditary_Pancreatitis				A	142459677	A	A	142459677	3	1	244	1	0	0	0	0	1	0	0	0	12614	1291	45	3	263	3	PRSS1	7	142459677	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	3665658	142459677	16678986	27	17407											
POLB	5423	broad.mit.edu	37	chr8	42220141	42220141	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attctacagccaaaactgttAcatcaggttgtggagcagtt	9	8	2	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr8:42220141A>G	uc003xoz.1	+	11	746	c.633A>G	c.(631-633)TTA>TTG	p.L211L	POLB_uc003xpa.1_Intron|POLB_uc011lcs.1_Silent_p.L57L	NM_002690	NP_002681	P06746	DPOLB_HUMAN	DNA-directed DNA polymerase beta	211					DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			ovary(1)|breast(1)	2	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)	CAAAACTGTTACATCAGGTTG	0.303								DNA_polymerases_(catalytic_subunits)					G	42220141	G	G	42220141	2	3	244	1	0	0	0	0	0	0	0	1	12189	388	14	4		4	POLB	8	42220141	Silent	SNP	A	TCGA-41-2573-01A-01D-1495-08		42220141	104143881	28	17408											
FAM83H	286077	broad.mit.edu	37	chr8	144808347	144808347	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggtccccaagctgtccgagCggaagatggctgaacacttg	14	11	0	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr8:144808347C>T	uc003yzk.2	-	5	3353	c.3284G>A	c.(3283-3285)CGC>CAC	p.R1095H	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1095					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCTGTCCGAGCGGAAGATGGC	0.697													T	144808347	T	T	144808347	3	4	244	1	0	0	0	0	1	0	0	0	5640	768	27	1	259	1	FAM83H	8	144808347	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	102588206	144808347	1555675	29	17409											
NFKBIL2	4796	broad.mit.edu	37	chr8	145661200	145661200	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgcttggctcgggcacgGggcctgctctcctcactgtc	12	16	2	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr8:145661200G>A	uc011llg.1	-	17	2631	c.2616C>T	c.(2614-2616)CCC>CCT	p.P872P	uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	872					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTCGGGCACGGGGCCTGCTCT	0.577													A	145661200	A	A	145661200	2	1	244	1	0	0	0	0	0	0	0	1	10382	1219	43	3		3	NFKBIL2	8	145661200	Silent	SNP	G	TCGA-41-2573-01A-01D-1495-08	852853	145661200	702822	30	17410											
CEP110	11064	broad.mit.edu	37	chr9	123912528	123912528	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catttgtgcctcctcctggaTacatgatgtatactgtgctt	8	10	0	1	rs145241861	by1000genomes	TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr9:123912528T>C	uc004bkx.1	+	23	3761	c.3730T>C	c.(3730-3732)TAC>CAC	p.Y1244H	CEP110_uc004bky.1_Missense_Mutation_p.Y848H|CEP110_uc004bla.1_Missense_Mutation_p.Y692H|CEP110_uc010mvo.1_5'UTR|CEP110_uc004blb.1_5'Flank	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1244	Pro-rich.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						TCCTCCTGGATACATGATGTA	0.502													C	123912528	C	C	123912528	3	2	244	1	0	0	0	0	1	0	0	0	3245	1406	49	4	3820	4	CEP110	9	123912528	Missense_Mutation	SNP	T	TCGA-41-2573-01A-01D-1495-08		123912528	17300903	31	17411											
COL5A1	1289	broad.mit.edu	37	chr9	137591840	137591840	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcctggtctccatctacaaCgagcagggtatccagcagat	9	12	2	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr9:137591840C>T	uc004cfe.2	+	3	745	c.363C>T	c.(361-363)AAC>AAT	p.N121N		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	121	TSP N-terminal.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCATCTACAACGAGCAGGGTA	0.587													T	137591840	T	T	137591840	2	4	244	1	0	0	0	0	0	0	0	1	3696	535	19	1		1	COL5A1	9	137591840	Silent	SNP	C	TCGA-41-2573-01A-01D-1495-08	13679312	137591840	3621591	32	17412											
SOHLH1	402381	broad.mit.edu	37	chr9	138586241	138586241	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggccccactcacccggccacGagctgggaccagcagtcagc	12	18	2	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr9:138586241G>A	uc004cgl.2	-	7	999	c.938C>T	c.(937-939)TCG>TTG	p.S313L	SOHLH1_uc010nbe.2_Missense_Mutation_p.S313L	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	313					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		ACCCGGCCACGAGCTGGGACC	0.637													A	138586241	A	A	138586241	3	1	244	1	0	0	0	0	1	0	0	0	14923	1059	37	2	274	2	SOHLH1	9	138586241	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	994401	138586241	2627190	33	17413											
PTEN	5728	broad.mit.edu	37	chr10	89692800	89692800	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttttgaagaccataaccCaccacagctagaacttatca	4	13	1	3			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr10:89692800C>T	uc001kfb.2	+	6	1315	c.284C>T	c.(283-285)CCA>CTA	p.P95L		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	95	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.P95S(4)|p.P95L(3)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.H93fs*5(1)|p.Q87_P96del(1)|p.N82_P95del(1)|p.F90_P95>L(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GACCATAACCCACCACAGCTA	0.348		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89692800	T	T	89692800	3	4	244	1	0	0	0	0	1	0	0	0	12738	594	21	3	302	3	PTEN	10	89692800	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08		89692800	45841947	34	17414											
PHRF1	57661	broad.mit.edu	37	chr11	608268	608268	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctgcggaggccatcccccCcagagccctgggatgaggag	16	14	0	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr11:608268C>T	uc001lqe.2	+	14	2943	c.2812C>T	c.(2812-2814)CCA>TCA	p.P938S	PHRF1_uc010qwc.1_Missense_Mutation_p.P937S|PHRF1_uc010qwd.1_Missense_Mutation_p.P936S|PHRF1_uc010qwe.1_Missense_Mutation_p.P934S|PHRF1_uc009ybz.1_Missense_Mutation_p.P728S|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	938							RNA polymerase binding|zinc ion binding				0						GCCATCCCCCCCAGAGCCCTG	0.697													T	608268	T	T	608268	3	4	244	1	0	0	0	0	1	0	0	0	11861	623	22	3	2859	3	PHRF1	11	608268	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08		608268	134398248	35	17415											
OR51D1	390038	broad.mit.edu	37	chr11	4661911	4661911	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acctacttgctgctaccaccTgtagtcaacccccttgtcta	5	16	2	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr11:4661911T>A	uc010qyk.1	+	1	891	c.891T>A	c.(889-891)CCT>CCA	p.P297P		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	297	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTACCACCTGTAGTCAACC	0.522													A	4661911	A	A	4661911	2	1	244	1	0	0	0	0	0	0	0	1	11093	1567	55	5		5	OR51D1	11	4661911	Silent	SNP	T	TCGA-41-2573-01A-01D-1495-08	4053643	4661911	130344605	36	17416											
OR51T1	401665	broad.mit.edu	37	chr11	4904034	4904034	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgaagaccaagacaatccGccaggctatgttccagctgc	9	13	0	3	rs151076376	byFrequency	TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr11:4904034G>A	uc010qyp.1	+	1	986	c.986G>A	c.(985-987)CGC>CAC	p.R329H		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGACAATCCGCCAGGCTATG	0.483													A	4904034	A	A	4904034	3	1	244	1	0	0	0	0	1	0	0	0	11106	1087	38	1	988	1	OR51T1	11	4904034	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	242123	4904034	130102482	37	17417											
SLC17A6	57084	broad.mit.edu	37	chr11	22399231	22399231	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaaaagaaagaggaatttgTacaaggagaagtacaagact	12	3	0	4			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr11:22399231T>C	uc001mqk.2	+	12	2107	c.1694T>C	c.(1693-1695)GTA>GCA	p.V565A		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	565	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						GAGGAATTTGTACAAGGAGAA	0.353													C	22399231	C	C	22399231	3	2	244	1	0	0	0	0	1	0	0	0	14421	1638	57	4	1740	4	SLC17A6	11	22399231	Missense_Mutation	SNP	T	TCGA-41-2573-01A-01D-1495-08	17495197	22399231	112607285	38	17418											
OR4C15	81309	broad.mit.edu	37	chr11	55322570	55322570	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgggtttatctgcatcataaActtctccttgttgcttgtct	7	9	4	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr11:55322570A>T	uc010rig.1	+	1	788	c.788A>T	c.(787-789)AAC>ATC	p.N263I		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGCATCATAAACTTCTCCTTG	0.478										HNSCC(20;0.049)			T	55322570	T	T	55322570	3	4	244	1	0	0	0	0	1	0	0	0	11048	43	2	5	790	5	OR4C15	11	55322570	Missense_Mutation	SNP	A	TCGA-41-2573-01A-01D-1495-08	32923339	55322570	79683946	39	17419											
VWF	7450	broad.mit.edu	37	chr12	6138532	6138532	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgtctgcttcaggaccacGgagatgctcaggtggcggtc	14	10	3	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr12:6138532G>A	uc001qnn.1	-	22	3193	c.2943C>T	c.(2941-2943)TCC>TCT	p.S981S	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	981	VWFD 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	TCAGGACCACGGAGATGCTCA	0.522													A	6138532	A	A	6138532	2	1	244	1	0	0	0	0	0	0	0	1	17243	1103	39	2		2	VWF	12	6138532	Silent	SNP	G	TCGA-41-2573-01A-01D-1495-08		6138532	127713363	40	17420											
A2M	2	broad.mit.edu	37	chr12	9225468	9225468	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggagagccaccactgtgtcCtgttagagacagatgagtga	13	8	0	5			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr12:9225468C>A	uc001qvk.1	-	30	3870	c.3757_splice	c.e30-1	p.D1253_splice	A2M_uc001qvj.1_Splice_Site_p.D295_splice|A2M_uc009zgk.1_Splice_Site_p.D1103_splice	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor						blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CCACTGTGTCCTGTTAGAGAC	0.478													A	9225468	A	A	9225468	5	1	244	1	0	0	0	0	0	0	1	0	4	695	24	5	696	5	A2M	12	9225468	Splice_Site	SNP	C	TCGA-41-2573-01A-01D-1495-08	3086936	9225468	124626427	41	17421											
YARS2	51067	broad.mit.edu	37	chr12	32908585	32908585	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggtcgaagccacagtaaatgGtttggggaaaactcgccgtg	14	8	0	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr12:32908585G>C	uc001rli.2	-	1	290	c.224C>G	c.(223-225)ACC>AGC	p.T75S		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	75					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	ACAGTAAATGGTTTGGGGAAA	0.577											OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	32908585	C	C	32908585	3	2	244	1	0	0	0	0	1	0	0	0	17465	1261	44	5	1229	5	YARS2	12	32908585	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08	23683117	32908585	100943310	42	17422											
CPNE8	144402	broad.mit.edu	37	chr12	39079420	39079420	+	Splice_Site	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gggttttgaggattcccattCtgtagaaatttataggcaaa	10	5	1	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr12:39079420C>A	uc001rls.1	-	16	1228	c.1144_splice	c.e16-1	p.N382_splice	CPNE8_uc001rlr.1_Splice_Site_p.N41_splice	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII											pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				GATTCCCATTCTGTAGAAATT	0.383													A	39079420	A	A	39079420	5	1	244	1	0	0	0	0	0	0	1	0	3818	927	32	5	571	5	CPNE8	12	39079420	Splice_Site	SNP	C	TCGA-41-2573-01A-01D-1495-08	6170835	39079420	94772475	43	17423											
ALX1	8092	broad.mit.edu	37	chr12	85695101	85695101	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accagttcagccacgtgcccCtcaacaattttttcactgac	5	15	3	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr12:85695101C>T	uc001tae.3	+	4	833	c.829C>T	c.(829-831)CTC>TTC	p.L277F		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	277					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		CCACGTGCCCCTCAACAATTT	0.473													T	85695101	T	T	85695101	3	4	244	1	0	0	0	0	1	0	0	0	556	681	24	3	843	3	ALX1	12	85695101	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	46615681	85695101	48156794	44	17424											
ZNF10	7556	broad.mit.edu	37	chr12	133732883	133732883	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caggagacaaactgtacacaTgtaatcagtgtgggaaatct	10	7	2	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr12:133732883T>C	uc009zzb.2	+	5	1498	c.1051T>C	c.(1051-1053)TGT>CGT	p.C351R	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.C351R	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	351	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		ACTGTACACATGTAATCAGTG	0.413													C	133732883	C	C	133732883	3	2	244	1	0	0	0	0	1	0	0	0	17709	1464	51	4	1065	4	ZNF10	12	133732883	Missense_Mutation	SNP	T	TCGA-41-2573-01A-01D-1495-08	48037782	133732883	119012	45	17425											
RYR3	6263	broad.mit.edu	37	chr15	33822868	33822868	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcactctttcagcggaatgGtaagcagctctggtgcccac	12	12	3	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr15:33822868G>A	uc001zhi.2	+	4	424	c.354_splice	c.e4+1	p.M118_splice	RYR3_uc010bar.2_Splice_Site_p.M118_splice	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGCGGAATGGTAAGCAGCTC	0.498													A	33822868	A	A	33822868	5	1	244	1	0	0	0	0	0	0	1	0	13770	1275	44	3	369	3	RYR3	15	33822868	Splice_Site	SNP	G	TCGA-41-2573-01A-01D-1495-08		33822868	68708524	46	17426											
MGRN1	23295	broad.mit.edu	37	chr16	4731741	4731741	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacatcctggacagcagccGccagaagggcaggccgcaga	13	15	0	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr16:4731741G>A	uc002cwz.2	+	13	1458	c.1322G>A	c.(1321-1323)CGC>CAC	p.R441H	MGRN1_uc002cxa.2_Missense_Mutation_p.R441H|MGRN1_uc010btx.2_Missense_Mutation_p.R420H|MGRN1_uc010btw.2_Missense_Mutation_p.R420H|MGRN1_uc002cxb.2_Missense_Mutation_p.R480H|MGRN1_uc010uxo.1_Missense_Mutation_p.R419H|MGRN1_uc010uxp.1_Missense_Mutation_p.R419H|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	441					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						GACAGCAGCCGCCAGAAGGGC	0.662													A	4731741	A	A	4731741	3	1	244	1	0	0	0	0	1	0	0	0	9559	1087	38	1	1375	1	MGRN1	16	4731741	Missense_Mutation	SNP	G	TCGA-41-2573-01A-01D-1495-08		4731741	85623012	47	17427											
ATP6V0D1	9114	broad.mit.edu	37	chr16	67472549	67472549	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacgaaggcatagaagacaCcaaagtggaactggttcagg	12	8	2	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr16:67472549C>T	uc002ete.1	-	8	1038	c.938G>A	c.(937-939)GGT>GAT	p.G313D	ATP6V0D1_uc010vjo.1_Missense_Mutation_p.G354D|ATP6V0D1_uc010vjn.1_Missense_Mutation_p.G236D	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	313					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		ATAGAAGACACCAAAGTGGAA	0.547													T	67472549	T	T	67472549	3	4	244	1	0	0	0	0	1	0	0	0	1173	507	18	3	121	3	ATP6V0D1	16	67472549	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	62740808	67472549	22882204	48	17428											
FA2H	79152	broad.mit.edu	37	chr16	74750318	74750318	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtaggagcccttgtgcggCgagccaaagtgcaggtagta	16	8	0	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr16:74750318C>T	uc002fde.1	-	6	1034	c.966G>A	c.(964-966)TCG>TCA	p.S322S	FA2H_uc002fdd.1_Silent_p.S95S|FA2H_uc010vmy.1_RNA	NM_024306	NP_077282	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	322					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity				0						CCTTGTGCGGCGAGCCAAAGT	0.602													T	74750318	T	T	74750318	2	4	244	1	0	0	0	0	0	0	0	1	5352	755	27	1		1	FA2H	16	74750318	Silent	SNP	C	TCGA-41-2573-01A-01D-1495-08	7277769	74750318	15604435	49	17429											
USP6	9098	broad.mit.edu	37	chr17	5042870	5042870	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acctggatatagggggccctTggttcccccattatgatttt	10	10	0	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr17:5042870T>A	uc002gau.1	+	22	3629	c.1399T>A	c.(1399-1401)TGG>AGG	p.W467R	USP6_uc002gav.1_Missense_Mutation_p.W467R|USP6_uc010ckz.1_Missense_Mutation_p.W150R|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	467					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						AGGGGGCCCTTGGTTCCCCCA	0.617			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								A	5042870	A	A	5042870	3	1	244	1	0	0	0	0	1	0	0	0	17083	1812	63	5	1449	5	USP6	17	5042870	Missense_Mutation	SNP	T	TCGA-41-2573-01A-01D-1495-08		5042870	76152340	50	17430											
MYH1	4619	broad.mit.edu	37	chr17	10412802	10412802	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgcaaaaagcaagccaacCttctcgatgagctcgatgca	8	12	2	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr17:10412802C>T	uc002gmo.2	-	15	1681	c.1587G>A	c.(1585-1587)AAG>AAA	p.K529K	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	529	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GCAAGCCAACCTTCTCGATGA	0.433													T	10412802	T	T	10412802	2	4	244	1	0	0	0	0	0	0	0	1	10029	695	24	3		3	MYH1	17	10412802	Silent	SNP	C	TCGA-41-2573-01A-01D-1495-08	5369932	10412802	70782408	51	17431											
FKBP10	60681	broad.mit.edu	37	chr17	39969482	39969482	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagatgggggattttgtgCgctaccactacaacggcact	12	10	0	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr17:39969482C>T	uc002hxv.2	+	1	521	c.196C>T	c.(196-198)CGC>TGC	p.R66C	SC65_uc002hxt.2_5'Flank|SC65_uc002hxu.2_5'Flank	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	66	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GGATTTTGTGCGCTACCACTA	0.502													T	39969482	T	T	39969482	3	4	244	1	0	0	0	0	1	0	0	0	5902	768	27	1	198	1	FKBP10	17	39969482	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	29556680	39969482	41225728	52	17432											
PPM1D	8493	broad.mit.edu	37	chr17	58725371	58725371	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	attatattggggagtgatggActttggaatatgattccacc	11	5	0	2			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr17:58725371A>T	uc002iyt.1	+	4	1167	c.945A>T	c.(943-945)GGA>GGT	p.G315G	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	315	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			GGAGTGATGGACTTTGGAATA	0.413													T	58725371	T	T	58725371	2	4	244	1	0	0	0	0	0	0	0	1	12337	262	10	5		5	PPM1D	17	58725371	Silent	SNP	A	TCGA-41-2573-01A-01D-1495-08	18755889	58725371	22469839	53	17433											
DNAH17	8632	broad.mit.edu	37	chr17	76420172	76420172	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgaagatgacaggcatggCcggggtcagctctttcagcc	14	10	3	3			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr17:76420172C>T	uc010dhp.1	-	26	4426	c.4204G>A	c.(4204-4206)GCC>ACC	p.A1402T	PGS1_uc002jvm.2_3'UTR|PGS1_uc010wtt.1_RNA|PGS1_uc010dho.2_RNA|PGS1_uc002jvn.2_3'UTR|PGS1_uc002jvo.2_RNA|DNAH17_uc002jvq.2_Missense_Mutation_p.A687T|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ACAGGCATGGCCGGGGTCAGC	0.602													T	76420172	T	T	76420172	3	4	244	1	0	0	0	0	1	0	0	0	4601	739	26	3	188	3	DNAH17	17	76420172	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	17694801	76420172	4775038	54	17434											
KIAA1012	22878	broad.mit.edu	37	chr18	29435678	29435678	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tattgcctcctctgccttctTcattttcaagagaattactt	4	11	4	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr18:29435678T>C	uc002kxc.3	-	21	3645	c.3281A>G	c.(3280-3282)GAA>GGA	p.E1094G	KIAA1012_uc002kxb.3_Missense_Mutation_p.E1040G|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1094					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TCTGCCTTCTTCATTTTCAAG	0.353													C	29435678	C	C	29435678	3	2	244	1	0	0	0	0	1	0	0	0	8204	1783	62	4	1062	4	KIAA1012	18	29435678	Missense_Mutation	SNP	T	TCGA-41-2573-01A-01D-1495-08		29435678	48641570	55	17435											
GDF5	8200	broad.mit.edu	37	chr20	34022173	34022173	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaggtcccgtttcttggtgCggccaaacaccaggaacagg	12	12	1	0			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr20:34022173C>T	uc002xck.1	-	2	1359	c.1040G>A	c.(1039-1041)CGC>CAC	p.R347H	GDF5_uc010gfc.1_Missense_Mutation_p.R347H|uc002xcj.2_Missense_Mutation_p.A195V|GDF5_uc010zvc.1_Missense_Mutation_p.R347H	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	347					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			TTTCTTGGTGCGGCCAAACAC	0.632													T	34022173	T	T	34022173	3	4	244	1	0	0	0	0	1	0	0	0	6316	768	27	1	469	1	GDF5	20	34022173	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08		34022173	29003347	56	17436											
LAMA5	3911	broad.mit.edu	37	chr20	60900398	60900398	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagtccccccggtagctggCggggcacaggcacagctcca	14	15	0	1			TCGA-41-2573-01A-01D-1495-08	TCGA-41-2573-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	fadc9e2a-d97d-4e86-a814-4f32f8cfd7a5	ad85c116-07e1-41be-a8e7-48502fb1e629	g.chr20:60900398C>T	uc002ycq.2	-	41	5570	c.5503G>A	c.(5503-5505)GCC>ACC	p.A1835T		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1835	Laminin EGF-like 16; second part.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGTAGCTGGCGGGGCACAGG	0.672													T	60900398	T	T	60900398	3	4	244	1	0	0	0	0	1	0	0	0	8609	768	27	1	5744	1	LAMA5	20	60900398	Missense_Mutation	SNP	C	TCGA-41-2573-01A-01D-1495-08	26878225	60900398	2125122	57	17437											
LRRC47	57470	broad.mit.edu	37	chr1	3699235	3699235	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccaccctacctttgtcttcTcactgttggttattggtggg	10	11	2	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr1:3699235T>C	uc001akx.1	-	5	1431	c.1403A>G	c.(1402-1404)GAG>GGG	p.E468G		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	468					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		CTTTGTCTTCTCACTGTTGGT	0.398													C	3699235	C	C	3699235	3	2	245	1	0	0	0	0	1	0	0	0	9004	1551	54	4	360	4	LRRC47	1	3699235	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08		3699235	245551386	1	17438											
PRAMEF12	390999	broad.mit.edu	37	chr1	12837263	12837263	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tccgtcagctaaaagagctaGacctgaggggcatcacactg	11	11	2	3			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr1:12837263G>C	uc001aui.2	+	3	1000	c.973G>C	c.(973-975)GAC>CAC	p.D325H		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	325	LRR 1.									ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAAAGAGCTAGACCTGAGGGG	0.577													C	12837263	C	C	12837263	3	2	245	1	0	0	0	0	1	0	0	0	12428	942	33	5	983	5	PRAMEF12	1	12837263	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	9138028	12837263	236413358	2	17439											
FHL3	2275	broad.mit.edu	37	chr1	38464646	38464646	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgagcccctgaacacatacCaggcatgacagtctccccac	7	16	1	3			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr1:38464646C>T	uc001ccj.2	-	3	418	c.331G>A	c.(331-333)GGG>AGG	p.G111R	FHL3_uc001cck.2_Missense_Mutation_p.G111R|FHL3_uc001ccl.2_Missense_Mutation_p.G111R|FHL3_uc001ccm.2_Missense_Mutation_p.G3R|FHL3_uc009vvl.1_Missense_Mutation_p.G111R	NM_004468	NP_004459	Q13643	FHL3_HUMAN	four and a half LIM domains 3	111	LIM zinc-binding 2.				muscle organ development		zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GAACACATACCAGGCATGACA	0.527													T	38464646	T	T	38464646	3	4	245	1	0	0	0	0	1	0	0	0	5880	608	21	3	527	3	FHL3	1	38464646	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	25627383	38464646	210785975	3	17440											
CDCP2	200008	broad.mit.edu	37	chr1	54605733	54605733	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taggagctggggtactgtggGctggagaagttgccccgcat	17	8	0	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr1:54605733G>A	uc001cwv.1	-	4	1658	c.810C>T	c.(808-810)AGC>AGT	p.S270S		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	270	CUB 3.					extracellular region				ovary(1)	1						GGTACTGTGGGCTGGAGAAGT	0.617													A	54605733	A	A	54605733	2	1	245	1	0	0	0	0	0	0	0	1	3094	1194	42	3		3	CDCP2	1	54605733	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08	16141087	54605733	194644888	4	17441											
RPF1	80135	broad.mit.edu	37	chr1	84962001	84962001	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taccttaaaattaaggtctcTtcagaaaggaacctttgatt	6	7	2	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr1:84962001T>C	uc001djv.3	+	8	1001	c.956T>C	c.(955-957)CTT>CCT	p.L319P		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	319	RNA-binding (By similarity).|Brix.				rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						TTAAGGTCTCTTCAGAAAGGA	0.323													C	84962001	C	C	84962001	3	2	245	1	0	0	0	0	1	0	0	0	13546	1609	56	4	986	4	RPF1	1	84962001	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	30356268	84962001	164288620	5	17442											
FLG	2312	broad.mit.edu	37	chr1	152282534	152282534	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctggaagccgactcagaccGcctctcagagtcttctgagt	10	13	5	3			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr1:152282534G>A	uc001ezu.1	-	3	4864	c.4828C>T	c.(4828-4830)CGG>TGG	p.R1610W		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1610	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTCAGACCGCCTCTCAGAG	0.572									Ichthyosis				A	152282534	A	A	152282534	3	1	245	1	0	0	0	0	1	0	0	0	5922	1086	38	1	7361	1	FLG	1	152282534	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	67320533	152282534	96968087	6	17443											
NCSTN	23385	broad.mit.edu	37	chr1	160318815	160318815	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttagtggagacacaggggttAtccacgtagtagagaaagag	14	5	0	3			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr1:160318815A>G	uc001fvx.2	+	3	341	c.217A>G	c.(217-219)ATC>GTC	p.I73V	NCSTN_uc009wtk.1_RNA|NCSTN_uc001fvy.2_Missense_Mutation_p.I53V|NCSTN_uc010pjf.1_Missense_Mutation_p.I73V|NCSTN_uc001fvz.2_5'Flank|NCSTN_uc010pjg.1_5'Flank	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	73	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CACAGGGGTTATCCACGTAGT	0.468													G	160318815	G	G	160318815	3	3	245	1	0	0	0	0	1	0	0	0	10241	449	16	4	227	4	NCSTN	1	160318815	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08	8036281	160318815	88931806	7	17444											
RYR2	6262	broad.mit.edu	37	chr1	237780610	237780610	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcctactgcttcagtacctcTgtgactgccaggtccggcac	10	15	2	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr1:237780610T>C	uc001hyl.1	+	38	5860	c.5740T>C	c.(5740-5742)TGT>CGT	p.C1914R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1914	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCAGTACCTCTGTGACTGCCA	0.383													C	237780610	C	C	237780610	3	2	245	1	0	0	0	0	1	0	0	0	13769	1580	55	4	5890	4	RYR2	1	237780610	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	77461795	237780610	11470011	8	17445											
TMEM214	54867	broad.mit.edu	37	chr2	27263616	27263616	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	actgcatgaagacacagctcAgtgaggctgtccactggacc	11	12	1	3			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr2:27263616A>T	uc002ria.3	+	17	2091	c.1981A>T	c.(1981-1983)AGT>TGT	p.S661C	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.S616C	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	661						integral to membrane	protein binding				0						GACACAGCTCAGTGAGGCTGT	0.532													T	27263616	T	T	27263616	3	4	245	1	0	0	0	0	1	0	0	0	16134	188	7	5	2047	5	TMEM214	2	27263616	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08		27263616	215935757	9	17446											
THSD7B	80731	broad.mit.edu	37	chr2	138421119	138421119	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	aatacatgatatttttaaagGatggtctcttcaaccacttg	6	7	2	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr2:138421119G>T	uc002tva.1	+	25	4538	c.4538G>T	c.(4537-4539)GGA>GTA	p.G1513V	THSD7B_uc010zbj.1_RNA	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATTTTTAAAGGATGGTCTCTT	0.368													T	138421119	T	T	138421119	3	4	245	1	0	0	0	0	1	0	0	0	15877	1174	41	5	4635	5	THSD7B	2	138421119	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	111157503	138421119	104778254	10	17447											
SCN3A	6328	broad.mit.edu	37	chr2	165996030	165996030	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggctatgctcacggctcttTgccttccagaggaatcctcc	9	14	2	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr2:165996030T>C	uc002ucx.2	-	14	2600	c.2108A>G	c.(2107-2109)CAA>CGA	p.Q703R	SCN3A_uc002ucy.2_Missense_Mutation_p.Q654R|SCN3A_uc002ucz.2_Missense_Mutation_p.Q654R|SCN3A_uc002uda.1_Missense_Mutation_p.Q523R|SCN3A_uc002udb.1_Missense_Mutation_p.Q523R	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	703						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CACGGCTCTTTGCCTTCCAGA	0.463													C	165996030	C	C	165996030	3	2	245	1	0	0	0	0	1	0	0	0	13918	1812	63	4	3954	4	SCN3A	2	165996030	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	27574911	165996030	77203343	11	17448											
TTN	7273	broad.mit.edu	37	chr2	179610349	179610349	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctgcaaagctctcagccattCctgatttgtttgtagctaca	7	11	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr2:179610349C>A	uc002unb.2	-	46	17002	c.16778G>T	c.(16777-16779)GGA>GTA	p.G5593V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	9063							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCAGCCATTCCTGATTTGTT	0.378													A	179610349	A	A	179610349	3	1	245	1	0	0	0	0	1	0	0	0	16732	855	30	5	93519	5	TTN	2	179610349	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	13614319	179610349	63589024	12	17449											
DNAJC10	54431	broad.mit.edu	37	chr2	183597246	183597246	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgtttgacttcacagacaCgactcaggcttagtggcatg	10	9	2	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr2:183597246C>T	uc002uow.1	+	10	1241	c.826C>T	c.(826-828)CGA>TGA	p.R276*	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Nonsense_Mutation_p.R276*|DNAJC10_uc010fro.1_Intron	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	276					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTCACAGACACGACTCAGGCT	0.348													T	183597246	T	T	183597246	4	4	245	1	0	0	0	0	0	1	0	0	4629	528	19	1	856	1	DNAJC10	2	183597246	Nonsense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	3986897	183597246	59602127	13	17450											
MOBKL3	25843	broad.mit.edu	37	chr2	198415097	198415097	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttcatcatcggcagatatTtgatgaatatgaagtaagta	8	4	2	4			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr2:198415097T>C	uc002uun.3	+	7	573	c.533T>C	c.(532-534)TTT>TCT	p.F178S	MOBKL3_uc002uum.3_Missense_Mutation_p.F146S|MOBKL3_uc010fsn.2_Missense_Mutation_p.F157S|MOBKL3_uc010fso.2_Missense_Mutation_p.F79S|MOBKL3_uc010zgz.1_Missense_Mutation_p.F79S	NM_015387	NP_056202	Q9Y3A3	MOBL3_HUMAN	Mps One Binder kinase activator-like 3 isoform	178					transport	Golgi cisterna membrane|perinuclear region of cytoplasm	metal ion binding|protein binding				0			Epithelial(96;0.225)			CGGCAGATATTTGATGAATAT	0.313													C	198415097	C	C	198415097	3	2	245	1	0	0	0	0	1	0	0	0	9687	1841	64	4	559	4	MOBKL3	2	198415097	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	14817851	198415097	44784276	14	17451											
PLCL1	5334	broad.mit.edu	37	chr2	198950332	198950332	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtggttatgttctaaggccGtctataatgcgagatgaagt	12	5	2	2	rs147854527	by1000genomes	TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr2:198950332G>A	uc010fsp.2	+	2	2382	c.2091G>A	c.(2089-2091)CCG>CCA	p.P697P	PLCL1_uc002uuv.3_Silent_p.P618P	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	697	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TTCTAAGGCCGTCTATAATGC	0.458													A	198950332	A	A	198950332	2	1	245	1	0	0	0	0	0	0	0	1	12039	1132	40	1		1	PLCL1	2	198950332	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08	535235	198950332	44249041	15	17452											
ZDBF2	57683	broad.mit.edu	37	chr2	207174816	207174816	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggagtttagggaaggtcgttTccactgttactttgatgatg	13	5	0	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr2:207174816T>G	uc002vbp.2	+	5	5814	c.5564T>G	c.(5563-5565)TTC>TGC	p.F1855C		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1855							nucleic acid binding|zinc ion binding			ovary(3)	3						GAAGGTCGTTTCCACTGTTAC	0.418													G	207174816	G	G	207174816	3	3	245	1	0	0	0	0	1	0	0	0	17596	1783	62	5	5574	5	ZDBF2	2	207174816	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	8224484	207174816	36024557	16	17453											
FBLN2	2199	broad.mit.edu	37	chr3	13679178	13679178	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgcctgcgcatatcttccGcattggccccgcgccagcct	11	17	1	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr3:13679178G>A	uc011avb.1	+	17	3439	c.3314G>A	c.(3313-3315)CGC>CAC	p.R1105H	FBLN2_uc011auz.1_Missense_Mutation_p.R1131H|FBLN2_uc011ava.1_Missense_Mutation_p.R1152H|FBLN2_uc011avc.1_Missense_Mutation_p.R1152H	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	1105	Domain III.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CATATCTTCCGCATTGGCCCC	0.617													A	13679178	A	A	13679178	3	1	245	1	0	0	0	0	1	0	0	0	5699	1087	38	1	2211	1	FBLN2	3	13679178	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08		13679178	184343252	17	17454											
CASR	846	broad.mit.edu	37	chr3	121981197	121981197	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagatatatatacctgcttaCctgggagagggctcttcacc	9	10	2	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr3:121981197C>A	uc003eev.3	+	4	1687	c.1315C>A	c.(1315-1317)CCT>ACT	p.P439T	CASR_uc003eew.3_Missense_Mutation_p.P439T	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	439	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TACCTGCTTACCTGGGAGAGG	0.453													A	121981197	A	A	121981197	3	1	245	1	0	0	0	0	1	0	0	0	2682	507	18	5	1325	5	CASR	3	121981197	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	108302019	121981197	76041233	18	17455											
FETUB	26998	broad.mit.edu	37	chr3	186362631	186362631	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caagtgctggaggctgccacCgagtctcttgcgaaatacaa	11	11	1	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr3:186362631C>T	uc010hyq.2	+	5	777	c.516C>T	c.(514-516)ACC>ACT	p.T172T	FETUB_uc011brz.1_Silent_p.T24T|FETUB_uc003fqn.2_Silent_p.T172T|FETUB_uc003fqo.2_Silent_p.T67T|FETUB_uc010hyr.2_Silent_p.T135T|FETUB_uc010hys.2_Silent_p.T24T|FETUB_uc003fqp.3_Silent_p.T107T	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	172	Cystatin fetuin-B-type 2.					extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		AGGCTGCCACCGAGTCTCTTG	0.473													T	186362631	T	T	186362631	2	4	245	1	0	0	0	0	0	0	0	1	5821	639	23	2		2	FETUB	3	186362631	Silent	SNP	C	TCGA-41-2575-01A-01D-1495-08	64381434	186362631	11659799	19	17456											
RAB28	9364	broad.mit.edu	37	chr4	13383174	13383174	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	accattttcctggcaaaaccGtaagtgtttttcaggtttta	7	8	1	0	rs139395840	byFrequency	TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr4:13383174G>C	uc003gmu.2	-	5	651	c.436C>G	c.(436-438)CGG>GGG	p.R146G	RAB28_uc003gmt.2_Missense_Mutation_p.R146G|RAB28_uc011bwz.1_Missense_Mutation_p.R146G|RAB28_uc003gmv.2_RNA	NM_001017979	NP_001017979	P51157	RAB28_HUMAN	RAB28, member RAS oncogene family isoform 1	146					small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity	p.R146W(1)		ovary(1)|skin(1)	2						TGGCAAAACCGTAAGTGTTTT	0.328													C	13383174	C	C	13383174	3	2	245	1	0	0	0	0	1	0	0	0	12916	1144	40	5	381	5	RAB28	4	13383174	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08		13383174	177771102	20	17457											
NCAPG	64151	broad.mit.edu	37	chr4	17819684	17819684	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagcagattttgccagagcCtgtagtatatgcagactatt	10	7	0	4			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr4:17819684C>T	uc003gpp.2	+	7	1267	c.1091C>T	c.(1090-1092)CCT>CTT	p.P364L	NCAPG_uc011bxj.1_5'UTR	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	364					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		TTGCCAGAGCCTGTAGTATAT	0.368													T	17819684	T	T	17819684	3	4	245	1	0	0	0	0	1	0	0	0	10207	681	24	3	1117	3	NCAPG	4	17819684	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	4436510	17819684	173334592	21	17458											
ENAM	10117	broad.mit.edu	37	chr4	71508380	71508380	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggggccaaataaacaccctGtaggaactactgttgcccca	9	12	0	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr4:71508380G>T	uc011caw.1	+	9	1518	c.1237G>T	c.(1237-1239)GTA>TTA	p.V413L		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	413					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			TAAACACCCTGTAGGAACTAC	0.468													T	71508380	T	T	71508380	3	4	245	1	0	0	0	0	1	0	0	0	5112	1377	48	5	1267	5	ENAM	4	71508380	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	53688696	71508380	119645896	22	17459											
HEATR7B2	133558	broad.mit.edu	37	chr5	41009468	41009468	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caagagtttcccactggaggCtggcttttcagccagcgcct	11	13	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr5:41009468C>G	uc003jmj.3	-	32	3824	c.3334G>C	c.(3334-3336)GCC>CCC	p.A1112P	HEATR7B2_uc003jmi.3_Missense_Mutation_p.A667P	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1112	HEAT 12.						binding			ovary(6)|central_nervous_system(2)	8						CCACTGGAGGCTGGCTTTTCA	0.498													G	41009468	G	G	41009468	3	3	245	1	0	0	0	0	1	0	0	0	7035	797	28	5	1467	5	HEATR7B2	5	41009468	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08		41009468	139905792	23	17460											
PCDHGA3	56112	broad.mit.edu	37	chr5	140724302	140724302	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atccaagtgatagtcctggaTgcaaatgacaacccaccaat	7	11	0	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr5:140724302T>G	uc003ljm.1	+	1	702	c.702T>G	c.(700-702)GAT>GAG	p.D234E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.D234E	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	234	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGTCCTGGATGCAAATGACA	0.527													G	140724302	G	G	140724302	3	3	245	1	0	0	0	0	1	0	0	0	11555	1461	51	5	704	5	PCDHGA3	5	140724302	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	99714834	140724302	40190958	24	17461											
PCDHGB4	8641	broad.mit.edu	37	chr5	140768648	140768648	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttaacttcttcaagaaacacGtataaattagtgacagatgc	6	7	2	3			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr5:140768648G>A	uc003lkc.1	+	1	1197	c.1197G>A	c.(1195-1197)ACG>ACA	p.T399T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.T399T	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	399	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAGAAACACGTATAAATTAG	0.433													A	140768648	A	A	140768648	2	1	245	1	0	0	0	0	0	0	0	1	11565	1132	40	1		1	PCDHGB4	5	140768648	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08	44346	140768648	40146612	25	17462											
RNF130	55819	broad.mit.edu	37	chr5	179390508	179390508	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agctgtggctctgatgatcaTgtagcagagtgtgagggcac	15	7	2	4			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr5:179390508T>G	uc003mll.1	-	8	1614	c.1207A>C	c.(1207-1209)ATG>CTG	p.M403L	RNF130_uc003mlm.1_Intron	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	403	Cytoplasmic (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGATGATCATGTAGCAGAGT	0.443													G	179390508	G	G	179390508	3	3	245	1	0	0	0	0	1	0	0	0	13438	1464	51	5	60	5	RNF130	5	179390508	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	38621860	179390508	1524752	26	17463											
TRIM7	81786	broad.mit.edu	37	chr5	180625194	180625194	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	catccctacctttctcctctTtctccagctctccccgaagg	4	19	4	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr5:180625194T>A	uc003mmz.1	-	6	1080	c.1013A>T	c.(1012-1014)AAA>ATA	p.K338I	TRIM7_uc003mmv.1_Missense_Mutation_p.K156I|TRIM7_uc003mmw.1_Missense_Mutation_p.K130I|TRIM7_uc003mmx.1_Missense_Mutation_p.K130I|TRIM7_uc003mmy.1_Missense_Mutation_p.K130I	NM_203293	NP_976038	Q9C029	TRIM7_HUMAN	tripartite motif-containing 7 isoform 1	338	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		TTTCTCCTCTTTCTCCAGCTC	0.517													A	180625194	A	A	180625194	3	1	245	1	0	0	0	0	1	0	0	0	16540	1841	64	5	530	5	TRIM7	5	180625194	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	1234686	180625194	290066	27	17464											
LY6G6C	80740	broad.mit.edu	37	chr6	31687971	31687971	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccttgtagcaggagtgacagCgaatgtcagctgggaagaca	14	8	1	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr6:31687971C>A	uc003nwh.2	-	2	116	c.62G>T	c.(61-63)CGC>CTC	p.R21L	LY6G6C_uc010jtd.2_RNA	NM_025261	NP_079537	O95867	LY66C_HUMAN	lymphocyte antigen 6 complex G6C precursor	21	UPAR/Ly6.					anchored to membrane|plasma membrane					0						GGAGTGACAGCGAATGTCAGC	0.592													A	31687971	A	A	31687971	3	1	245	1	0	0	0	0	1	0	0	0	9094	768	27	5	323	5	LY6G6C	6	31687971	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08		31687971	139427096	28	17465											
DNAH8	1769	broad.mit.edu	37	chr6	38805720	38805720	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taaaaacctttgttacaggcCagtttcgatgatctgtggag	10	7	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr6:38805720C>A	uc003ooe.1	+	31	4317	c.3717C>A	c.(3715-3717)GCC>GCA	p.A1239A		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGTTACAGGCCAGTTTCGATG	0.264													A	38805720	A	A	38805720	2	1	245	1	0	0	0	0	0	0	0	1	4607	581	21	5		5	DNAH8	6	38805720	Silent	SNP	C	TCGA-41-2575-01A-01D-1495-08	7117749	38805720	132309347	29	17466											
TAAR1	134864	broad.mit.edu	37	chr6	132966395	132966395	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cacaatccccaatgtcttcaCagctttcctttctttgcttt	3	14	3	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr6:132966395C>G	uc003qdm.1	-	1	748	c.748G>C	c.(748-750)GTG>CTG	p.V250L		NM_138327	NP_612200	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	250	Cytoplasmic (Potential).					plasma membrane					0	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	AATGTCTTCACAGCTTTCCTT	0.393													G	132966395	G	G	132966395	3	3	245	1	0	0	0	0	1	0	0	0	15486	478	17	5	275	5	TAAR1	6	132966395	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	94160675	132966395	38148672	30	17467											
C6orf211	79624	broad.mit.edu	37	chr6	151789913	151789913	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgggtaaatgggtttaccacAatcatatattttggactctg	9	6	2	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr6:151789913A>C	uc003qok.1	+	5	1253	c.994A>C	c.(994-996)AAT>CAT	p.N332H	C6orf211_uc011ees.1_Missense_Mutation_p.N213H	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	332							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		GGTTTACCACAATCATATATT	0.383													C	151789913	C	C	151789913	3	2	245	1	0	0	0	0	1	0	0	0	2354	130	5	5	1012	5	C6orf211	6	151789913	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08	18823518	151789913	19325154	31	17468											
MRPL32	64983	broad.mit.edu	37	chr7	42977023	42977023	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggagactgcagaaatcagaCgacagatagggaagcaagaa	13	6	1	5			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr7:42977023C>T	uc003tia.2	+	3	462	c.415C>T	c.(415-417)CGA>TGA	p.R139*	MRPL32_uc003tib.2_RNA|MRPL32_uc003tic.2_Nonsense_Mutation_p.R86*	NM_031903	NP_114109	Q9BYC8	RM32_HUMAN	mitochondrial ribosomal protein L32 precursor	139					translation	large ribosomal subunit|mitochondrial ribosome	structural constituent of ribosome				0						AGAAATCAGACGACAGATAGG	0.493													T	42977023	T	T	42977023	4	4	245	1	0	0	0	0	0	1	0	0	9795	528	19	1	425	1	MRPL32	7	42977023	Nonsense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08		42977023	116161640	32	17469											
MYO1G	64005	broad.mit.edu	37	chr7	45016575	45016575	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gctcacggccctggtacctgGcgatggcctcaggcccatac	12	16	2	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr7:45016575G>C	uc003tmh.2	-	2	335	c.191C>G	c.(190-192)GCC>GGC	p.A64G	MYO1G_uc003tmg.2_5'Flank|MYO1G_uc010kym.2_Intron|MYO1G_uc003tmi.1_5'UTR|MYO1G_uc003tmj.2_5'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	64	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						CTGGTACCTGGCGATGGCCTC	0.627													C	45016575	C	C	45016575	3	2	245	1	0	0	0	0	1	0	0	0	10074	1203	42	5	2949	5	MYO1G	7	45016575	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	2039552	45016575	114122088	33	17470											
FZD1	8321	broad.mit.edu	37	chr7	90895152	90895152	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgaggagctgcgcttctcGcgcacctggattggcatttg	13	13	1	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr7:90895152G>A	uc003ula.2	+	1	1370	c.957G>A	c.(955-957)TCG>TCA	p.S319S		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	319	Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGCGCTTCTCGCGCACCTGGA	0.617													A	90895152	A	A	90895152	2	1	245	1	0	0	0	0	0	0	0	1	6128	1074	38	1		1	FZD1	7	90895152	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08	45878577	90895152	68243511	34	17471											
TAF6	6878	broad.mit.edu	37	chr7	99705016	99705016	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gacggggacgatgccgggggAggaactggagaaggatggga	22	5	0	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr7:99705016A>G	uc003uti.2	-	15	1968	c.1887T>C	c.(1885-1887)CCT>CCC	p.P629P	AP4M1_uc003utd.2_Intron|TAF6_uc003utg.2_Silent_p.P551P|TAF6_uc003uth.2_Silent_p.P686P|TAF6_uc003utk.2_Silent_p.P629P|TAF6_uc011kji.1_Silent_p.P666P|TAF6_uc003utj.2_Silent_p.P619P|TAF6_uc003utl.2_Silent_p.P619P|TAF6_uc003utm.2_Silent_p.P629P	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	629					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATGCCGGGGGAGGAACTGGAG	0.647													G	99705016	G	G	99705016	2	3	245	1	0	0	0	0	0	0	0	1	15527	291	11	4		4	TAF6	7	99705016	Silent	SNP	A	TCGA-41-2575-01A-01D-1495-08	8809864	99705016	59433647	35	17472											
ZCWPW1	55063	broad.mit.edu	37	chr7	100017408	100017408	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgtctctggggaactgatccCcggggtctcctccttagggg	14	12	2	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr7:100017408C>A	uc003uut.2	-	4	375	c.127G>T	c.(127-129)GGG>TGG	p.G43W	ZCWPW1_uc011kjq.1_5'Flank|ZCWPW1_uc003uur.2_5'Flank|ZCWPW1_uc003uus.2_5'UTR|ZCWPW1_uc011kjr.1_Missense_Mutation_p.G42W|ZCWPW1_uc003uuu.1_Missense_Mutation_p.G42W|ZCWPW1_uc011kjs.1_5'Flank|ZCWPW1_uc011kjt.1_Missense_Mutation_p.G42W|ZCWPW1_uc011kju.1_Missense_Mutation_p.G42W	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	43							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAACTGATCCCCGGGGTCTCC	0.493													A	100017408	A	A	100017408	3	1	245	1	0	0	0	0	1	0	0	0	17594	623	22	5	1879	5	ZCWPW1	7	100017408	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	312392	100017408	59121255	36	17473											
KCNU1	157855	broad.mit.edu	37	chr8	36766969	36766969	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tataccaggaaggagctgaaGgacatagtgttcattgggtc	13	6	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr8:36766969G>T	uc010lvw.2	+	21	2334	c.2247G>T	c.(2245-2247)AAG>AAT	p.K749N	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	749	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AGGAGCTGAAGGACATAGTGT	0.458													T	36766969	T	T	36766969	3	4	245	1	0	0	0	0	1	0	0	0	8093	991	35	5	2329	5	KCNU1	8	36766969	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08		36766969	109597053	37	17474											
FGFR1	2260	broad.mit.edu	37	chr8	38282202	38282202	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	accctgcttgcaggatgggcCggtgaggggaccgctctgtg	17	11	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr8:38282202C>A	uc003xlp.2	-	7	1703	c.761G>T	c.(760-762)CGG>CTG	p.R254L	FGFR1_uc011lbo.1_Missense_Mutation_p.R252L|FGFR1_uc011lbp.1_Missense_Mutation_p.R165L|FGFR1_uc011lbq.1_Missense_Mutation_p.R163L|FGFR1_uc010lwk.2_Missense_Mutation_p.R246L|FGFR1_uc011lbr.1_RNA|FGFR1_uc011lbs.1_Missense_Mutation_p.R94L|FGFR1_uc011lbt.1_Missense_Mutation_p.R163L|FGFR1_uc011lbu.1_Missense_Mutation_p.R285L|FGFR1_uc011lbv.1_Missense_Mutation_p.R252L|FGFR1_uc011lbw.1_Missense_Mutation_p.R165L|FGFR1_uc011lbx.1_Missense_Mutation_p.R165L|FGFR1_uc003xlv.2_Missense_Mutation_p.R165L|FGFR1_uc003xlu.2_Missense_Mutation_p.R163L	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	254	Extracellular (Potential).		R -> Q (in KAL2).		axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	CAGGATGGGCCGGTGAGGGGA	0.612		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						A	38282202	A	A	38282202	3	1	245	1	0	0	0	0	1	0	0	0	5863	652	23	5	1995	5	FGFR1	8	38282202	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	1515233	38282202	108081820	38	17475											
FNTA	2339	broad.mit.edu	37	chr8	42927324	42927324	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctcccttctttgggctttagGcatcataggcgagtattagt	10	9	2	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr8:42927324G>C	uc003xps.2	+	5	555	c.507G>C	c.(505-507)TGG>TGC	p.W169C	FNTA_uc003xpt.2_Missense_Mutation_p.W78C|FNTA_uc003xpu.2_Missense_Mutation_p.W102C|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	169	PFTA 2.				cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			TGGGCTTTAGGCATCATAGGC	0.368													C	42927324	C	C	42927324	3	2	245	1	0	0	0	0	1	0	0	0	5977	1217	42	5	525	5	FNTA	8	42927324	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	4645122	42927324	103436698	39	17476											
PXDNL	137902	broad.mit.edu	37	chr8	52339264	52339264	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catgacatgaaatgtttataTtctttccaacctcgacactt	4	10	1	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr8:52339264T>G	uc003xqu.3	-	13	1681	c.1580A>C	c.(1579-1581)AAT>ACT	p.N527T		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	527	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AATGTTTATATTCTTTCCAAC	0.338													G	52339264	G	G	52339264	3	3	245	1	0	0	0	0	1	0	0	0	12848	1493	52	5	2855	5	PXDNL	8	52339264	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	9411940	52339264	94024758	40	17477											
UBXN2B	137886	broad.mit.edu	37	chr8	59345800	59345800	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atggagaaaatcagctgcaaGatgtaggtacaataatcaaa	9	5	2	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr8:59345800G>T	uc003xtl.2	+	4	543	c.421G>T	c.(421-423)GAT>TAT	p.D141Y		NM_001077619	NP_001071087	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	141	SEP.					cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				ovary(2)	2						TCAGCTGCAAGATGTAGGTAC	0.284													T	59345800	T	T	59345800	3	4	245	1	0	0	0	0	1	0	0	0	16912	942	33	5	435	5	UBXN2B	8	59345800	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	7006536	59345800	87018222	41	17478											
LRRCC1	85444	broad.mit.edu	37	chr8	86047170	86047170	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	acgaaaagaaaatgagtcttCctctttaattaaagatctga	6	6	3	4			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr8:86047170C>T	uc003ycw.2	+	13	2211	c.2057C>T	c.(2056-2058)TCC>TTC	p.S686F	LRRCC1_uc010maa.1_Missense_Mutation_p.S387F|LRRCC1_uc003ycx.2_Missense_Mutation_p.S593F|LRRCC1_uc003ycy.2_Missense_Mutation_p.S666F	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	686					cell division|mitosis	centriole|nucleus					0						AATGAGTCTTCCTCTTTAATT	0.333													T	86047170	T	T	86047170	3	4	245	1	0	0	0	0	1	0	0	0	9026	855	30	3	2107	3	LRRCC1	8	86047170	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	26701370	86047170	60316852	42	17479											
GRHL2	79977	broad.mit.edu	37	chr8	102649132	102649132	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttttgttccacaggtgtattAcaacacggatgatgaacgag	10	7	0	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr8:102649132A>G	uc010mbu.2	+	12	1823	c.1493A>G	c.(1492-1494)TAC>TGC	p.Y498C		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	498						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			CAGGTGTATTACAACACGGAT	0.408													G	102649132	G	G	102649132	3	3	245	1	0	0	0	0	1	0	0	0	6764	391	14	4	1539	4	GRHL2	8	102649132	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08	16601962	102649132	43714890	43	17480											
PLEC	5339	broad.mit.edu	37	chr8	144996426	144996426	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtgccttggccacctcgtcCtggaagagctgctccagctt	11	14	0	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr8:144996426C>T	uc003zaf.1	-	32	8144	c.7974G>A	c.(7972-7974)CAG>CAA	p.Q2658Q	PLEC_uc003zab.1_Silent_p.Q2521Q|PLEC_uc003zac.1_Silent_p.Q2525Q|PLEC_uc003zad.2_Silent_p.Q2521Q|PLEC_uc003zae.1_Silent_p.Q2489Q|PLEC_uc003zag.1_Silent_p.Q2499Q|PLEC_uc003zah.2_Silent_p.Q2507Q|PLEC_uc003zaj.2_Silent_p.Q2548Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2658	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCACCTCGTCCTGGAAGAGCT	0.488													T	144996426	T	T	144996426	2	4	245	1	0	0	0	0	0	0	0	1	12052	680	24	3		3	PLEC	8	144996426	Silent	SNP	C	TCGA-41-2575-01A-01D-1495-08	42347294	144996426	1367596	44	17481											
FOXD4L5	653427	broad.mit.edu	37	chr9	70177706	70177706	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggccgccgcagaccttggcGgtgccctgaacttggtgcca	14	14	0	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr9:70177706G>A	uc010moc.2	-	1	1110	c.278C>T	c.(277-279)CCG>CTG	p.P93L		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	93					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						AGACCTTGGCGGTGCCCTGAA	0.682													A	70177706	A	A	70177706	3	1	245	1	0	0	0	0	1	0	0	0	6002	1116	39	2	976	2	FOXD4L5	9	70177706	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08		70177706	71035725	45	17482											
RET	5979	broad.mit.edu	37	chr10	43597850	43597850	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgtcacccacatcccttcGtgagggcgagtgccagtggc	12	15	1	1	rs138265837		TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr10:43597850G>A	uc001jal.2	+	3	588	c.398G>A	c.(397-399)CGT>CAT	p.R133H	RET_uc001jak.1_Missense_Mutation_p.R133H|RET_uc010qez.1_5'Flank	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	133	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	ACATCCCTTCGTGAGGGCGAG	0.617		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				A	43597850	A	A	43597850	3	1	245	1	0	0	0	0	1	0	0	0	13235	1145	40	1	408	1	RET	10	43597850	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08		43597850	91936897	46	17483											
FAM13C	220965	broad.mit.edu	37	chr10	61022289	61022289	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tccagaggagcttggctccgGgcccgcagcttccggtttcc	13	15	0	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr10:61022289G>C	uc001jkn.2	-	11	1275	c.1141C>G	c.(1141-1143)CCG>GCG	p.P381A	FAM13C_uc001jko.2_Intron|FAM13C_uc010qid.1_Missense_Mutation_p.P298A|FAM13C_uc010qie.1_Missense_Mutation_p.P298A|FAM13C_uc010qif.1_Missense_Mutation_p.P403A|FAM13C_uc001jkp.2_Missense_Mutation_p.P298A	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	381										ovary(2)	2						CTTGGCTCCGGGCCCGCAGCT	0.547													C	61022289	C	C	61022289	3	2	245	1	0	0	0	0	1	0	0	0	5454	1232	43	5	636	5	FAM13C	10	61022289	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	17424439	61022289	74512458	47	17484											
RNH1	6050	broad.mit.edu	37	chr11	494709	494709	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcaggagatgaccctcagGgatggcttgtccttctccag	11	13	3	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr11:494709G>A	uc001lpk.1	-	9	2776	c.1368C>T	c.(1366-1368)TCC>TCT	p.S456S	RNH1_uc001lpl.1_Silent_p.S456S|RNH1_uc001lpm.1_Silent_p.S456S|RNH1_uc001lpn.1_Silent_p.S456S|RNH1_uc001lpo.1_Silent_p.S456S|RNH1_uc009ybw.1_RNA|RNH1_uc001lpp.1_Silent_p.S456S|RNH1_uc001lpt.1_Silent_p.S213S|RNH1_uc001lpq.1_Silent_p.S456S|RNH1_uc001lpr.1_Silent_p.S456S|RNH1_uc001lps.1_Silent_p.S456S	NM_203389	NP_976323	P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor	456					mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity				0		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGACCCTCAGGGATGGCTTGT	0.647													A	494709	A	A	494709	2	1	245	1	0	0	0	0	0	0	0	1	13504	1219	43	3		3	RNH1	11	494709	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08		494709	134511807	48	17485											
CD59	966	broad.mit.edu	37	chr11	33731856	33731856	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgtcgttgaaattgcaatgcTcaaacttccaacacttgtta	6	10	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr11:33731856T>C	uc001mus.3	-	3	485	c.203A>G	c.(202-204)GAG>GGG	p.E68G	CD59_uc009yjx.2_Missense_Mutation_p.E68G|CD59_uc009yjy.2_Missense_Mutation_p.E68G|CD59_uc009yjz.2_Missense_Mutation_p.E68G|CD59_uc001mut.3_Missense_Mutation_p.E68G|CD59_uc009yka.2_Missense_Mutation_p.E68G|CD59_uc001muu.3_Missense_Mutation_p.E68G|CD59_uc001muv.3_Missense_Mutation_p.E68G|CD59_uc001mux.3_Missense_Mutation_p.S109G	NM_001127223	NP_001120695	P13987	CD59_HUMAN	CD59 antigen preproprotein	68	UPAR/Ly6.				blood coagulation|cell surface receptor linked signaling pathway	anchored to external side of plasma membrane|extracellular region|membrane fraction					0						ATTGCAATGCTCAAACTTCCA	0.433													C	33731856	C	C	33731856	3	2	245	1	0	0	0	0	1	0	0	0	3026	1551	54	4	187	4	CD59	11	33731856	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	33237147	33731856	101274660	49	17486											
OR5AK2	390181	broad.mit.edu	37	chr11	56756567	56756567	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagatttcaaacactcacgtActtttttctacaacatttgg	4	10	3	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr11:56756567A>G	uc010rjp.1	+	1	179	c.179A>G	c.(178-180)TAC>TGC	p.Y60C		NM_001005323	NP_001005323	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						ACACTCACGTACTTTTTTCTA	0.358													G	56756567	G	G	56756567	3	3	245	1	0	0	0	0	1	0	0	0	11142	391	14	4	181	4	OR5AK2	11	56756567	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08	23024711	56756567	78249949	50	17487											
PC	5091	broad.mit.edu	37	chr11	66618277	66618277	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggcacaggccagcatggctgCcacgcctgcccctgacgtgt	13	16	0	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr11:66618277C>A	uc001ojn.1	-	16	2390	c.2341G>T	c.(2341-2343)GCA>TCA	p.A781S	PC_uc001ojo.1_Missense_Mutation_p.A781S|PC_uc001ojp.1_Missense_Mutation_p.A781S|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	781	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AGCATGGCTGCCACGCCTGCC	0.657													A	66618277	A	A	66618277	3	1	245	1	0	0	0	0	1	0	0	0	11497	739	26	5	1219	5	PC	11	66618277	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	9861710	66618277	68388239	51	17488											
SLC38A4	55089	broad.mit.edu	37	chr12	47163207	47163207	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagtgtgatcactgatgtaCgaatcttaaacaagaaagtt	8	6	2	3			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr12:47163207C>T	uc001rpi.2	-	15	1703	c.1304G>A	c.(1303-1305)CGT>CAT	p.R435H	SLC38A4_uc001rpj.2_Missense_Mutation_p.R435H	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	435	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					CACTGATGTACGAATCTTAAA	0.353													T	47163207	T	T	47163207	3	4	245	1	0	0	0	0	1	0	0	0	14606	536	19	1	351	1	SLC38A4	12	47163207	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08		47163207	86688688	52	17489											
TFCP2	7024	broad.mit.edu	37	chr12	51501060	51501060	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ataggaaggctgatatttctCcttttcatgaggtgttcgtt	10	6	2	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr12:51501060C>T	uc001rxw.2	-	7	1246	c.787G>A	c.(787-789)GAG>AAG	p.E263K	TFCP2_uc001rxv.1_Missense_Mutation_p.E263K|TFCP2_uc009zlx.1_Missense_Mutation_p.E212K|TFCP2_uc001rxx.2_Missense_Mutation_p.E263K|TFCP2_uc009zly.1_Missense_Mutation_p.E165K	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	263	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGATATTTCTCCTTTTCATGA	0.323													T	51501060	T	T	51501060	3	4	245	1	0	0	0	0	1	0	0	0	15792	864	30	3	757	3	TFCP2	12	51501060	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	4337853	51501060	82350835	53	17490											
PCDH9	5101	broad.mit.edu	37	chr13	67802278	67802279	+	Frame_Shift_Del	DEL	CA	-	-													ctcagcatatgaggcgccagCacagagtttttctctgtcta							TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr13:67802278_67802279delCA	uc001vik.2	-	2	986_987	c.294_295delTG	c.(292-297)TGTGCTfs	p.C98fs	PCDH9_uc001vil.2_Frame_Shift_Del_p.C98fs|PCDH9_uc010thl.1_Frame_Shift_Del_p.C98fs|PCDH9_uc001vin.3_Frame_Shift_Del_p.C98fs	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	98_99	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GAGGCGCCAGCACAGAGTTTTT	0.436													-	67802279	-	-	67802278	7	5	245	1	0	1	0	1	0	0	0	0	11518	710	25	0	3434	0	PCDH9	13	67802278	Frame_Shift_Del	DEL	CA	TCGA-41-2575-01A-01D-1495-08		67802278	47367600	54	17491											
FARP1	10160	broad.mit.edu	37	chr13	99061722	99061722	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctctcccttgatcagcccGctgctgaatgaccaggcctg	10	16	2	3			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr13:99061722G>A	uc001vnj.2	+	14	1881	c.1545G>A	c.(1543-1545)CCG>CCA	p.P515P	FARP1_uc001vnh.2_Silent_p.P515P	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	515					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TGATCAGCCCGCTGCTGAATG	0.652													A	99061722	A	A	99061722	2	1	245	1	0	0	0	0	0	0	0	1	5676	1074	38	1		1	FARP1	13	99061722	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08	31259444	99061722	16108156	55	17492											
RNASE2	6036	broad.mit.edu	37	chr14	21424331	21424331	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gacaccagcaaacatgttctAtatagttgcatgtgacaaca	7	9	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr14:21424331A>T	uc010aif.2	+	2	470	c.401A>T	c.(400-402)TAT>TTT	p.Y134F	RNASE2_uc001vyl.1_Missense_Mutation_p.Y134F	NM_002934	NP_002925	P10153	RNAS2_HUMAN	ribonuclease, RNase A family, 2 (liver,	134					chemotaxis|RNA catabolic process	extracellular region|lysosome	nucleic acid binding|pancreatic ribonuclease activity			ovary(1)	1	all_cancers(95;0.00381)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)		AACATGTTCTATATAGTTGCA	0.463													T	21424331	T	T	21424331	3	4	245	1	0	0	0	0	1	0	0	0	13404	449	16	5	403	5	RNASE2	14	21424331	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08		21424331	85925209	56	17493											
JUB	84962	broad.mit.edu	37	chr14	23444297	23444297	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcctggatgataggacttcCccattgcttgtaggatctgg	12	9	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr14:23444297C>T	uc001whz.2	-	5	1632	c.1256G>A	c.(1255-1257)GGG>GAG	p.G419E	JUB_uc001why.2_Missense_Mutation_p.G2E	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	419	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		ATAGGACTTCCCCATTGCTTG	0.502													T	23444297	T	T	23444297	3	4	245	1	0	0	0	0	1	0	0	0	7968	623	22	3	376	3	JUB	14	23444297	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	2019966	23444297	83905243	57	17494											
KCNH5	27133	broad.mit.edu	37	chr14	63316419	63316419	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gaccatgttgagacaatataAtccatgactcgctcactaag	7	10	1	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr14:63316419A>T	uc001xfx.2	-	8	1572	c.1521T>A	c.(1519-1521)GAT>GAA	p.D507E	KCNH5_uc001xfy.2_Missense_Mutation_p.D507E|KCNH5_uc001xfz.1_Missense_Mutation_p.D449E	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	507	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		AGACAATATAATCCATGACTC	0.378													T	63316419	T	T	63316419	3	4	245	1	0	0	0	0	1	0	0	0	8035	98	4	5	1495	5	KCNH5	14	63316419	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08	39872122	63316419	44033121	58	17495											
ADAMTS7	11173	broad.mit.edu	37	chr15	79059849	79059849	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctctgctcatccagccccaCgctgcggatgcagagcacgg	12	16	2	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr15:79059849C>T	uc002bej.3	-	18	2942	c.2731G>A	c.(2731-2733)GTG>ATG	p.V911M	ADAMTS7_uc010und.1_Intron	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	911	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						TCCAGCCCCACGCTGCGGATG	0.706													T	79059849	T	T	79059849	3	4	245	1	0	0	0	0	1	0	0	0	271	536	19	1	2357	1	ADAMTS7	15	79059849	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08		79059849	23471543	59	17496											
ADAMTS17	170691	broad.mit.edu	37	chr15	100591784	100591784	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacggccactcacctccgccGcactgcacactgcacccttc	6	22	1	0	rs146325180	by1000genomes	TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr15:100591784G>A	uc002bvv.1	-	17	2527	c.2448C>T	c.(2446-2448)TGC>TGT	p.C816C		NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	816	TSP type-1 2.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CACCTCCGCCGCACTGCACAC	0.567													A	100591784	A	A	100591784	2	1	245	1	0	0	0	0	0	0	0	1	262	1079	38	1		1	ADAMTS17	15	100591784	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08	21531935	100591784	1939608	60	17497											
IL4R	3566	broad.mit.edu	37	chr16	27374437	27374437	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggagcagggtggcacccaGgccagtgcggtggtgggctt	20	9	0	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr16:27374437G>A	uc002don.2	+	11	2006	c.1764G>A	c.(1762-1764)CAG>CAA	p.Q588Q	IL4R_uc002dop.3_Silent_p.Q573Q|IL4R_uc010bxy.2_Silent_p.Q588Q|IL4R_uc002doo.2_Silent_p.Q428Q	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	588	Required for IL4-induced gene expression.|Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						GTGGCACCCAGGCCAGTGCGG	0.637													A	27374437	A	A	27374437	2	1	245	1	0	0	0	0	0	0	0	1	7698	991	35	3		3	IL4R	16	27374437	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08		27374437	62980316	61	17498											
YWHAE	7531	broad.mit.edu	37	chr17	1303395	1303395	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctggtacaccagatcctctcGatcatccatagcggcagcgg	10	14	2	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr17:1303395G>A	uc002fsj.2	-	1	162	c.10C>T	c.(10-12)CGA>TGA	p.R4*	YWHAE_uc002fsk.2_5'UTR|YWHAE_uc010vqh.1_RNA|YWHAE_uc010vqi.1_RNA	NM_006761	NP_006752	P62258	1433E_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	4					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding			lung(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		AGATCCTCTCGATCATCCATA	0.657													A	1303395	A	A	1303395	4	1	245	1	0	0	0	0	0	1	0	0	17499	1066	37	2	781	2	YWHAE	17	1303395	Nonsense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08		1303395	79891815	62	17499											
YBX2	51087	broad.mit.edu	37	chr17	7194458	7194458	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccacagtctccccatctccaAcgctgcgcagaaacttcctg	6	18	2	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr17:7194458A>G	uc002gfq.2	-	4	470	c.413T>C	c.(412-414)GTT>GCT	p.V138A		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	138	CSD.|Required for cytoplasmic retention (By similarity).				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						CCCATCTCCAACGCTGCGCAG	0.502													G	7194458	G	G	7194458	3	3	245	1	0	0	0	0	1	0	0	0	17467	43	2	4	701	4	YBX2	17	7194458	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08	5891063	7194458	74000752	63	17500											
TP53	7157	broad.mit.edu	37	chr17	7577609	7577609	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtggtacagtcagagccaacCtaggagataacacaggccca	11	11	1	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr17:7577609C>G	uc002gim.2	-	7	867	c.673_splice	c.e7-1	p.V225_splice	TP53_uc002gig.1_Splice_Site_p.V225_splice|TP53_uc002gih.2_Splice_Site_p.V225_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.V93_splice|TP53_uc010cng.1_Splice_Site_p.V93_splice|TP53_uc002gii.1_Splice_Site_p.V93_splice|TP53_uc010cnh.1_Splice_Site_p.V225_splice|TP53_uc010cni.1_Splice_Site_p.V225_splice|TP53_uc002gij.2_Splice_Site_p.V225_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(12)|p.0?(7)|p.V225fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGAGCCAACCTAGGAGATAA	0.488		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			G	7577609	G	G	7577609	5	3	245	1	0	0	0	0	0	0	1	0	16378	695	24	5	618	5	TP53	17	7577609	Splice_Site	SNP	C	TCGA-41-2575-01A-01D-1495-08	383151	7577609	73617601	64	17501											
WDR16	146845	broad.mit.edu	37	chr17	9546402	9546402	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgaagtgactcacgttgggGtgggacacagtggcaacatc	15	8	1	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr17:9546402G>T	uc002gly.2	+	14	1819	c.1750G>T	c.(1750-1752)GTG>TTG	p.V584L	USP43_uc002gma.3_5'Flank|USP43_uc010cod.2_5'Flank|USP43_uc010vva.1_5'Flank|WDR16_uc002glz.2_Missense_Mutation_p.V516L|WDR16_uc010coc.2_Missense_Mutation_p.V594L	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	584						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TCACGTTGGGGTGGGACACAG	0.443													T	9546402	T	T	9546402	3	4	245	1	0	0	0	0	1	0	0	0	17273	1261	44	5	1804	5	WDR16	17	9546402	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	1968793	9546402	71648808	65	17502											
BRCA1	672	broad.mit.edu	37	chr17	41245683	41245683	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactgactactagttcaagcGcatgaatatgcctggtagaa	9	8	1	3	rs56039126		TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr17:41245683G>A	uc002icq.2	-	10	2097	c.1865C>T	c.(1864-1866)GCG>GTG	p.A622V	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.A551V|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.A575V|BRCA1_uc002ict.2_Missense_Mutation_p.A622V|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.A622V|BRCA1_uc002ide.1_Missense_Mutation_p.A453V|BRCA1_uc010cyy.1_Missense_Mutation_p.A622V|BRCA1_uc010whs.1_Missense_Mutation_p.A622V|BRCA1_uc010cyz.2_Missense_Mutation_p.A575V|BRCA1_uc010cza.2_Missense_Mutation_p.A596V|BRCA1_uc010wht.1_Missense_Mutation_p.A326V	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	622					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TAGTTCAAGCGCATGAATATG	0.358			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			A	41245683	A	A	41245683	3	1	245	1	0	0	0	0	1	0	0	0	1498	1087	38	1	3852	1	BRCA1	17	41245683	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08	31699281	41245683	39949527	66	17503											
CSH2	1443	broad.mit.edu	37	chr17	61950623	61950623	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaagcctggataacggaacGgtttggacggcaccagcctc	12	11	0	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr17:61950623G>A	uc002jch.2	-	2	202	c.87C>T	c.(85-87)ACC>ACT	p.T29T	CSH2_uc002jcg.2_Silent_p.T29T|CSH2_uc002jci.2_Silent_p.T29T|GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Silent_p.T29T	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	29					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						ATAACGGAACGGTTTGGACGG	0.597													A	61950623	A	A	61950623	2	1	245	1	0	0	0	0	0	0	0	1	3941	1103	39	2		2	CSH2	17	61950623	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08	20704940	61950623	19244587	67	17504											
BPTF	2186	broad.mit.edu	37	chr17	65888098	65888098	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tagtcagctgaagagccagcAggtggcagccgctgcacatg	14	11	1	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr17:65888098A>T	uc002jgf.2	+	5	2064	c.2003A>T	c.(2002-2004)CAG>CTG	p.Q668L	BPTF_uc002jge.2_Missense_Mutation_p.Q794L|BPTF_uc010wqm.1_Missense_Mutation_p.Q731L	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	794					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			AAGAGCCAGCAGGTGGCAGCC	0.433													T	65888098	T	T	65888098	3	4	245	1	0	0	0	0	1	0	0	0	1495	188	7	5	2407	5	BPTF	17	65888098	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08	3937475	65888098	15307112	68	17505											
ABCA6	23460	broad.mit.edu	37	chr17	67077247	67077247	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctgtgatagagggtaaacGtctgccacgggcagcttata	13	8	2	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr17:67077247G>A	uc002jhw.1	-	37	4831	c.4656C>T	c.(4654-4656)GAC>GAT	p.D1552D		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1552					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					GAGGGTAAACGTCTGCCACGG	0.373													A	67077247	A	A	67077247	2	1	245	1	0	0	0	0	0	0	0	1	36	1136	40	1		1	ABCA6	17	67077247	Silent	SNP	G	TCGA-41-2575-01A-01D-1495-08	1189149	67077247	14117963	69	17506											
SERPINB3	6317	broad.mit.edu	37	chr18	61323102	61323102	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctccagatagcacgagaccgCggctcccggtcatgcctgag	12	15	1	3	rs140650845	by1000genomes	TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr18:61323102C>T	uc002lji.2	-	8	1106	c.962G>A	c.(961-963)CGC>CAC	p.R321H	SERPINB4_uc002ljg.2_Intron|SERPINB3_uc010dqa.2_Missense_Mutation_p.R269H	NM_006919	NP_008850	P29508	SPB3_HUMAN	serine (or cysteine) proteinase inhibitor, clade	321					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CACGAGACCGCGGCTCCCGGT	0.542													T	61323102	T	T	61323102	3	4	245	1	0	0	0	0	1	0	0	0	14102	768	27	1	214	1	SERPINB3	18	61323102	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08		61323102	16754146	70	17507											
VAV1	7409	broad.mit.edu	37	chr19	6828653	6828653	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacctggctcagtgcgtgaaCgaggtcaagcgagacaacga	14	10	2	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr19:6828653C>T	uc002mfu.1	+	12	1210	c.1113C>T	c.(1111-1113)AAC>AAT	p.N371N	VAV1_uc010xjh.1_Silent_p.N339N|VAV1_uc010dva.1_Silent_p.N371N|VAV1_uc002mfv.1_Silent_p.N316N	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	371	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						AGTGCGTGAACGAGGTCAAGC	0.637													T	6828653	T	T	6828653	2	4	245	1	0	0	0	0	0	0	0	1	17128	535	19	1		1	VAV1	19	6828653	Silent	SNP	C	TCGA-41-2575-01A-01D-1495-08		6828653	52300330	71	17508											
TMEM205	374882	broad.mit.edu	37	chr19	11453778	11453778	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gacagtggccagcgtaaggcTcaggaacagcaggtaaagct	14	9	1	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr19:11453778T>G	uc002mrb.2	-	4	471	c.283A>C	c.(283-285)AGC>CGC	p.S95R	TMEM205_uc002mra.2_Missense_Mutation_p.S95R|TMEM205_uc002mqz.2_Missense_Mutation_p.S95R|TMEM205_uc002mrc.2_Missense_Mutation_p.S95R	NM_001145416	NP_001138888	Q6UW68	TM205_HUMAN	transmembrane protein 205	95	Helical; (Potential).					integral to membrane					0						AGCGTAAGGCTCAGGAACAGC	0.642													G	11453778	G	G	11453778	3	3	245	1	0	0	0	0	1	0	0	0	16127	1551	54	5	290	5	TMEM205	19	11453778	Missense_Mutation	SNP	T	TCGA-41-2575-01A-01D-1495-08	4625125	11453778	47675205	72	17509											
MLL4	9757	broad.mit.edu	37	chr19	36210728	36210728	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcgcaagcataagacgacccCccttcctcctcctcgcctag	6	19	0	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr19:36210728C>A	uc010eei.2	+	3	479	c.479C>A	c.(478-480)CCC>CAC	p.P160H		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	160					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGACGACCCCCCTTCCTCCT	0.612													A	36210728	A	A	36210728	3	1	245	1	0	0	0	0	1	0	0	0	9623	623	22	5	489	5	MLL4	19	36210728	Missense_Mutation	SNP	C	TCGA-41-2575-01A-01D-1495-08	24756950	36210728	22918255	73	17510											
LILRA4	23547	broad.mit.edu	37	chr19	54848149	54848149	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggggctcactggggtgagaCagcaggtaggggttggagct	20	6	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr19:54848149C>G	uc002qfj.2	-	6	1275	c.1218G>C	c.(1216-1218)CTG>CTC	p.L406L	LILRA4_uc002qfi.2_Silent_p.L340L	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	406	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TGGGGTGAGACAGCAGGTAGG	0.592													G	54848149	G	G	54848149	2	3	245	1	0	0	0	0	0	0	0	1	8787	465	17	5		5	LILRA4	19	54848149	Silent	SNP	C	TCGA-41-2575-01A-01D-1495-08	18637421	54848149	4280834	74	17511											
ZIM3	114026	broad.mit.edu	37	chr19	57646590	57646590	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgaggtttttcttctggataAaggtatttccacatagatca	8	6	3	2			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr19:57646590A>T	uc002qnz.1	-	5	1501	c.1115T>A	c.(1114-1116)TTT>TAT	p.F372Y		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	372	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTTCTGGATAAAGGTATTTCC	0.378													T	57646590	T	T	57646590	3	4	245	1	0	0	0	0	1	0	0	0	17682	14	1	5	307	5	ZIM3	19	57646590	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08	2798441	57646590	1482393	75	17512											
SEMG1	6406	broad.mit.edu	37	chr20	43836974	43836974	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atagccaaaaggcaaataaaAtatcataccaatcttcaagt	4	8	3	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr20:43836974A>G	uc002xni.2	+	2	1093	c.1036A>G	c.(1036-1038)ATA>GTA	p.I346V	SEMG1_uc002xnj.2_Missense_Mutation_p.I286V|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	346	58 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				GGCAAATAAAATATCATACCA	0.393													G	43836974	G	G	43836974	3	3	245	1	0	0	0	0	1	0	0	0	14044	101	4	4	1042	4	SEMG1	20	43836974	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08		43836974	19188546	76	17513											
UBASH3A	53347	broad.mit.edu	37	chr21	43846877	43846877	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccagcagcagatgcagcgGggaatttcttccacaaacgg	12	11	1	1			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr21:43846877G>A	uc002zbe.2	+	8	1154	c.1118G>A	c.(1117-1119)GGG>GAG	p.G373E	UBASH3A_uc002zbf.2_Missense_Mutation_p.G335E|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.G335E	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	373						cytosol|nucleus				ovary(3)	3						AGATGCAGCGGGGAATTTCTT	0.473													A	43846877	A	A	43846877	3	1	245	1	0	0	0	0	1	0	0	0	16836	1232	43	3	1148	3	UBASH3A	21	43846877	Missense_Mutation	SNP	G	TCGA-41-2575-01A-01D-1495-08		43846877	4283018	77	17514											
GRAP2	9402	broad.mit.edu	37	chr22	40364194	40364194	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcagcaccagcaccagccacAgcctccgcaatatgccccag	8	19	0	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chr22:40364194A>C	uc003ayh.1	+	6	871	c.608A>C	c.(607-609)CAG>CCG	p.Q203P	GRAP2_uc003ayi.2_RNA|GRAP2_uc011aom.1_Missense_Mutation_p.Q177P|GRAP2_uc011aon.1_Missense_Mutation_p.Q137P|GRAP2_uc010gya.1_Missense_Mutation_p.Q203P|GRAP2_uc011aoo.1_Missense_Mutation_p.Q131P|GRAP2_uc011aop.1_Missense_Mutation_p.Q163P|GRAP2_uc011aoq.1_Missense_Mutation_p.Q90P|GRAP2_uc003ayj.1_Missense_Mutation_p.Q203P	NM_004810	NP_004801	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	203					cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						caccagccacagcctccgcaa	0.299													C	40364194	C	C	40364194	3	2	245	1	0	0	0	0	1	0	0	0	6754	188	7	5	626	5	GRAP2	22	40364194	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08		40364194	10940372	78	17515											
EIF2S3	1968	broad.mit.edu	37	chrX	24075581	24075581	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gggaaatccacagtcgtcaaAgctatttctggagttcatac	9	9	3	0			TCGA-41-2575-01A-01D-1495-08	TCGA-41-2575-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	4943e80a-d098-49cd-8261-1d53d42f8223	82ac95da-c623-4483-b2bd-300548e31e13	g.chrX:24075581A>T	uc004dbc.2	+	3	198	c.177A>T	c.(175-177)AAA>AAT	p.K59N		NM_001415	NP_001406	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2,	59						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			lung(1)	1						CAGTCGTCAAAGCTATTTCTG	0.328													T	24075581	T	T	24075581	3	4	245	1	0	0	0	0	1	0	0	0	5011	69	3	5	187	5	EIF2S3	23	24075581	Missense_Mutation	SNP	A	TCGA-41-2575-01A-01D-1495-08		24075581	131194979	79	17516											
UBE4B	10277	broad.mit.edu	37	chr1	10221285	10221285	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagtctggagtctctgaagCgaatccatgaagtgcaggaa	12	7	2	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:10221285C>T	uc001aqs.3	+	23	3852	c.3139C>T	c.(3139-3141)CGA>TGA	p.R1047*	UBE4B_uc001aqr.3_Nonsense_Mutation_p.R918*|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Nonsense_Mutation_p.R502*	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	1047					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GTCTCTGAAGCGAATCCATGA	0.493													T	10221285	T	T	10221285	4	4	246	1	0	0	0	0	0	1	0	0	16880	760	27	1	3229	1	UBE4B	1	10221285	Nonsense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08		10221285	239029336	1	17517											
NGF	4803	broad.mit.edu	37	chr1	115828973	115828973	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcccttgatgtctgtggcGgtggtcttatccccaaccca	10	13	2	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:115828973G>A	uc001efu.1	-	3	613	c.444C>T	c.(442-444)ACC>ACT	p.T148T		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	148					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	TGTCTGTGGCGGTGGTCTTAT	0.527													A	115828973	A	A	115828973	2	1	246	1	0	0	0	0	0	0	0	1	10395	1103	39	2		2	NGF	1	115828973	Silent	SNP	G	TCGA-41-3392-01A-01D-1495-08	105607688	115828973	133421648	2	17518											
GJA8	2703	broad.mit.edu	37	chr1	147380211	147380211	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttggcacggccgcagagttCgtgtggggggatgagcaatc	17	9	0	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:147380211C>T	uc001epu.1	+	2	192	c.129C>T	c.(127-129)TTC>TTT	p.F43F		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	43	Helical; (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					CCGCAGAGTTCGTGTGGGGGG	0.592													T	147380211	T	T	147380211	2	4	246	1	0	0	0	0	0	0	0	1	6405	883	31	2		2	GJA8	1	147380211	Silent	SNP	C	TCGA-41-3392-01A-01D-1495-08	31551238	147380211	101870410	3	17519											
RPTN	126638	broad.mit.edu	37	chr1	152128025	152128028	+	Frame_Shift_Del	DEL	TGTC	-	-													catagtggaaactctggcctTgtctgtctgtctgaccatag							TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:152128025_152128028delTGTC	uc001ezs.1	-	3	1612_1615	c.1547_1550delGACA	c.(1546-1551)AGACAAfs	p.R516fs		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	516_517	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						ACTCTGGCCTTGTCTGTCTGTCTG	0.5													-	152128028	-	-	152128025	7	5	246	1	0	1	0	1	0	0	0	0	13664	1812	63	0	808	0	RPTN	1	152128025	Frame_Shift_Del	DEL	TGTC	TCGA-41-3392-01A-01D-1495-08	4747814	152128025	97122596	4	17520											
FLG	2312	broad.mit.edu	37	chr1	152278815	152278815	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccctgagtgcctggagccGtctcctgattgttcctcatt	10	13	2	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:152278815G>A	uc001ezu.1	-	3	8583	c.8547C>T	c.(8545-8547)GAC>GAT	p.D2849D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2849	Ser-rich.|Filaggrin 17.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGGAGCCGTCTCCTGATT	0.567									Ichthyosis				A	152278815	A	A	152278815	2	1	246	1	0	0	0	0	0	0	0	1	5922	1136	40	1		1	FLG	1	152278815	Silent	SNP	G	TCGA-41-3392-01A-01D-1495-08	150790	152278815	96971806	5	17521											
SPTA1	6708	broad.mit.edu	37	chr1	158604390	158604390	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acagccaaagcattcttttcAttgatccaagcttcctcttc	4	13	3	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:158604390A>C	uc001fst.1	-	39	5707	c.5508T>G	c.(5506-5508)AAT>AAG	p.N1836K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1836	Spectrin 18.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CATTCTTTTCATTGATCCAAG	0.418													C	158604390	C	C	158604390	3	2	246	1	0	0	0	0	1	0	0	0	15115	214	8	5	1807	5	SPTA1	1	158604390	Missense_Mutation	SNP	A	TCGA-41-3392-01A-01D-1495-08	6325575	158604390	90646231	6	17522											
REN	5972	broad.mit.edu	37	chr1	204129738	204129738	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gactgtccctgttgaatagcGgagggtgagttctgttccat	13	8	1	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:204129738G>A	uc001haq.2	-	4	486	c.442C>T	c.(442-444)CGC>TGC	p.R148C		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	148					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GTTGAATAGCGGAGGGTGAGT	0.562													A	204129738	A	A	204129738	3	1	246	1	0	0	0	0	1	0	0	0	13224	1116	39	2	806	2	REN	1	204129738	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	45525348	204129738	45120883	7	17523											
RASSF5	83593	broad.mit.edu	37	chr1	206760184	206760184	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccttctccatccctgaactTcagaacttcctaacaatcct	3	16	2	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:206760184T>G	uc001hed.2	+	6	1188	c.1131T>G	c.(1129-1131)CTT>CTG	p.L377L	RASSF5_uc001hec.1_3'UTR|RASSF5_uc001hee.2_3'UTR|RASSF5_uc001hef.2_Silent_p.L224L|RASSF5_uc001heg.1_3'UTR	NM_182663	NP_872604	Q8WWW0	RASF5_HUMAN	Ras association (RalGDS/AF-6) domain family 5	377	SARAH.				apoptosis|intracellular signal transduction	cytoplasm|microtubule	metal ion binding|protein binding			ovary(1)	1	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			TCCCTGAACTTCAGAACTTCC	0.458													G	206760184	G	G	206760184	2	3	246	1	0	0	0	0	0	0	0	1	13089	1770	62	5		5	RASSF5	1	206760184	Silent	SNP	T	TCGA-41-3392-01A-01D-1495-08	2630446	206760184	42490437	8	17524											
IRF6	3664	broad.mit.edu	37	chr1	209963984	209963984	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataaatggcatgaccgctgaCctccaggatcagtcctctgt	9	12	2	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:209963984C>T	uc001hhq.1	-	7	1179	c.916G>A	c.(916-918)GTC>ATC	p.V306I	IRF6_uc010psm.1_Missense_Mutation_p.V211I|IRF6_uc009xct.1_Missense_Mutation_p.V306I	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	306					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		TGACCGCTGACCTCCAGGATC	0.532										HNSCC(57;0.16)			T	209963984	T	T	209963984	3	4	246	1	0	0	0	0	1	0	0	0	7834	507	18	3	499	3	IRF6	1	209963984	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	3203800	209963984	39286637	9	17525											
OR2T12	127064	broad.mit.edu	37	chr1	248458187	248458187	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggcaaaggccttcttgcGggcttctgtagagcgcatga	15	9	2	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr1:248458187G>A	uc010pzj.1	-	1	694	c.694C>T	c.(694-696)CGC>TGC	p.R232C		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GCCTTCTTGCGGGCTTCTGTA	0.522													A	248458187	A	A	248458187	3	1	246	1	0	0	0	0	1	0	0	0	11019	1116	39	2	271	2	OR2T12	1	248458187	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	38494203	248458187	792434	10	17526											
NBAS	51594	broad.mit.edu	37	chr2	15615941	15615941	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttaaagcaccagagcatcgaGctaaagtcactgcactgtct	8	11	2	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr2:15615941G>A	uc002rcc.1	-	14	1237	c.1211C>T	c.(1210-1212)GCT>GTT	p.A404V	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	404										ovary(2)|liver(1)|skin(1)	4						AGAGCATCGAGCTAAAGTCAC	0.398													A	15615941	A	A	15615941	3	1	246	1	0	0	0	0	1	0	0	0	10186	971	34	3	6060	3	NBAS	2	15615941	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08		15615941	227583432	11	17527											
WDR92	116143	broad.mit.edu	37	chr2	68358402	68358402	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gagctttgtaacgatcagtaCtctcaccgtttggtcaaatg	9	9	3	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr2:68358402C>G	uc002see.1	-	8	1123	c.1042G>C	c.(1042-1044)GTA>CTA	p.V348L	WDR92_uc002sed.1_Intron	NM_138458	NP_612467	Q96MX6	WDR92_HUMAN	monad	348	WD 6.				apoptosis|histone lysine methylation		methylated histone residue binding				0						ACGATCAGTACTCTCACCGTT	0.323													G	68358402	G	G	68358402	3	3	246	1	0	0	0	0	1	0	0	0	17336	565	20	5	35	5	WDR92	2	68358402	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	52742461	68358402	174840971	12	17528											
TTC31	64427	broad.mit.edu	37	chr2	74710499	74710499	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtcgctgctgcacccaaaCtttgcaaggaattcggtcca	10	12	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr2:74710499C>T	uc002slt.2	+	2	114	c.91C>T	c.(91-93)CTT>TTT	p.L31F	TTC31_uc002sls.2_5'UTR|TTC31_uc010yrv.1_5'UTR|TTC31_uc002slu.2_5'UTR|CCDC142_uc002slo.2_5'Flank|CCDC142_uc002slq.2_5'Flank|CCDC142_uc002slr.2_5'Flank|CCDC142_uc002slp.2_5'Flank	NM_022492	NP_071937	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	31							binding				0						TGCACCCAAACTTTGCAAGGA	0.582											OREG0014719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	74710499	T	T	74710499	3	4	246	1	0	0	0	0	1	0	0	0	16697	565	20	3	97	3	TTC31	2	74710499	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	6352097	74710499	168488874	13	17529											
RAB3GAP1	22930	broad.mit.edu	37	chr2	135890504	135890504	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttctgagaaaccattagatGgaactacttcaacagataat	6	7	2	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr2:135890504G>C	uc002tuj.2	+	14	1301	c.1276G>C	c.(1276-1278)GGA>CGA	p.G426R	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.G426R|RAB3GAP1_uc010fng.2_Missense_Mutation_p.G251R|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	426						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		ACCATTAGATGGAACTACTTC	0.308													C	135890504	C	C	135890504	3	2	246	1	0	0	0	0	1	0	0	0	12935	1349	47	5	1330	5	RAB3GAP1	2	135890504	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	61180005	135890504	107308869	14	17530											
NEB	4703	broad.mit.edu	37	chr2	152580858	152580858	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacttatccttggtgtcttcCcagttctgcttgtataaaac	6	10	2	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr2:152580858C>T	uc010fnx.2	-	8	719	c.528G>A	c.(526-528)TGG>TGA	p.W176*		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	176	Nebulin 3.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGGTGTCTTCCCAGTTCTGCT	0.493													T	152580858	T	T	152580858	4	4	246	1	0	0	0	0	0	1	0	0	10302	624	22	3	25858	3	NEB	2	152580858	Nonsense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	16690354	152580858	90618515	15	17531											
TTN	7273	broad.mit.edu	37	chr2	179610717	179610717	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaaatatttcagaatctccCatggtgaggaatccccgaca	8	11	2	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr2:179610717C>T	uc002unb.2	-	46	16634	c.16410G>A	c.(16408-16410)ATG>ATA	p.M5470I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAATCTCCCATGGTGAGGA	0.398													T	179610717	T	T	179610717	3	4	246	1	0	0	0	0	1	0	0	0	16732	594	21	3	93887	3	TTN	2	179610717	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	27029859	179610717	63588656	16	17532											
C2orf83	56918	broad.mit.edu	37	chr2	228476292	228476292	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gccatggcccgcagggtgaaTgaaggtcagcccgcatgtct	14	12	2	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr2:228476292T>A	uc002vph.2	-	3	506	c.271A>T	c.(271-273)ATT>TTT	p.I91F	C2orf83_uc010zlu.1_3'UTR	NM_020161	NP_064546	Q53S99	CB083_HUMAN	hypothetical protein LOC56918 isoform 1	91						membrane	folic acid binding|reduced folate carrier activity				0						GCAGGGTGAATGAAGGTCAGC	0.517													A	228476292	A	A	228476292	3	1	246	1	0	0	0	0	1	0	0	0	2198	1464	51	5	185	5	C2orf83	2	228476292	Missense_Mutation	SNP	T	TCGA-41-3392-01A-01D-1495-08	48865575	228476292	14723081	17	17533											
TADA3	10474	broad.mit.edu	37	chr3	9825867	9825867	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaattagctcctccttgatGcggctctccagggacttagt	10	12	1	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr3:9825867G>A	uc003bsx.1	-	8	1499	c.951C>T	c.(949-951)CGC>CGT	p.R317R	TADA3_uc010hcn.1_Silent_p.R317R|TADA3_uc003bsy.2_Silent_p.R317R|TADA3_uc003bsw.1_Silent_p.R146R	NM_006354	NP_006345	O75528	TADA3_HUMAN	transcriptional adaptor 3 isoform a	317					estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity				0						CCTCCTTGATGCGGCTCTCCA	0.622													A	9825867	A	A	9825867	2	1	246	1	0	0	0	0	0	0	0	1	15509	1306	46	3		3	TADA3	3	9825867	Silent	SNP	G	TCGA-41-3392-01A-01D-1495-08		9825867	188196563	18	17534											
PLCL2	23228	broad.mit.edu	37	chr3	17052411	17052411	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtttagaaaaccactgttccAttaaacaacagaaggtaatg	7	7	0	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr3:17052411A>T	uc011awc.1	+	5	1654	c.1549A>T	c.(1549-1551)ATT>TTT	p.I517F	PLCL2_uc010het.1_Missense_Mutation_p.H126L|PLCL2_uc011awd.1_Missense_Mutation_p.I399F	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	525	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						CCACTGTTCCATTAAACAACA	0.373													T	17052411	T	T	17052411	3	4	246	1	0	0	0	0	1	0	0	0	12040	217	8	5	1573	5	PLCL2	3	17052411	Missense_Mutation	SNP	A	TCGA-41-3392-01A-01D-1495-08	7226544	17052411	180970019	19	17535											
SEC22C	9117	broad.mit.edu	37	chr3	42602655	42602655	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccattcatcaccccatttgcCacatctgtgtcctccagagt	5	16	3	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr3:42602655C>G	uc003clj.2	-	4	598	c.480G>C	c.(478-480)GTG>GTC	p.V160V	SEC22C_uc003clh.2_Silent_p.V160V|SEC22C_uc011azo.1_Silent_p.V90V|SEC22C_uc010hic.2_Silent_p.V160V|SEC22C_uc003cli.2_Silent_p.V160V	NM_032970	NP_116752	Q9BRL7	SC22C_HUMAN	SEC22 vesicle trafficking protein homolog C	160	Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.222)		CCCCATTTGCCACATCTGTGT	0.468													G	42602655	G	G	42602655	2	3	246	1	0	0	0	0	0	0	0	1	13990	581	21	5		5	SEC22C	3	42602655	Silent	SNP	C	TCGA-41-3392-01A-01D-1495-08	25550244	42602655	155419775	20	17536											
ARIH2	10425	broad.mit.edu	37	chr3	48965232	48965232	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atgagcacatgaccagcttaGcttctgtcctaaaggtgagc	10	10	1	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr3:48965232G>T	uc003cvb.2	+	3	553	c.241G>T	c.(241-243)GCT>TCT	p.A81S	ARIH2_uc003cvc.2_Missense_Mutation_p.A81S|ARIH2_uc003cvf.2_5'UTR|ARIH2_uc010hkl.2_Missense_Mutation_p.A81S|ARIH2_uc003cvd.1_Missense_Mutation_p.A81S|ARIH2_uc003cve.1_Missense_Mutation_p.A81S	NM_006321	NP_006312	O95376	ARI2_HUMAN	ariadne homolog 2	81					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		GACCAGCTTAGCTTCTGTCCT	0.483													T	48965232	T	T	48965232	3	4	246	1	0	0	0	0	1	0	0	0	924	971	34	5	243	5	ARIH2	3	48965232	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	6362577	48965232	149057198	21	17537											
ROBO2	6092	broad.mit.edu	37	chr3	77147196	77147196	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgccaggaggactttcccccGcggattgtggagcatccttc	12	14	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr3:77147196G>A	uc003dpy.3	+	2	736	c.93G>A	c.(91-93)CCG>CCA	p.P31P	ROBO2_uc003dpz.2_Silent_p.P31P|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Silent_p.P31P	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	31	Ig-like C2-type 1.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ACTTTCCCCCGCGGATTGTGG	0.537													A	77147196	A	A	77147196	2	1	246	1	0	0	0	0	0	0	0	1	13514	1087	38	1		1	ROBO2	3	77147196	Silent	SNP	G	TCGA-41-3392-01A-01D-1495-08	28181964	77147196	120875234	22	17538											
ADCY5	111	broad.mit.edu	37	chr3	123036910	123036910	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagcagatgaagaggaagaCgagcgaggcacacgccacat	13	9	0	4			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr3:123036910C>T	uc003egh.1	-	11	2311	c.2311G>A	c.(2311-2313)GTC>ATC	p.V771I	ADCY5_uc003egg.1_Missense_Mutation_p.V404I|ADCY5_uc003egi.1_Missense_Mutation_p.V330I	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	771	Helical; (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		AAGAGGAAGACGAGCGAGGCA	0.602													T	123036910	T	T	123036910	3	4	246	1	0	0	0	0	1	0	0	0	297	536	19	1	1518	1	ADCY5	3	123036910	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	45889714	123036910	74985520	23	17539											
TNFSF10	8743	broad.mit.edu	37	chr3	172241153	172241153	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgtcccaggctgggtccccCctggacctccatcatagcca	9	18	1	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr3:172241153C>A	uc003fid.2	-	1	117	c.22G>T	c.(22-24)GGG>TGG	p.G8W	TNFSF10_uc003fie.2_Missense_Mutation_p.G8W|TNFSF10_uc010hwu.1_RNA	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	8	Cytoplasmic (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CTGGGTCCCCCCTGGACCTCC	0.527													A	172241153	A	A	172241153	3	1	246	1	0	0	0	0	1	0	0	0	16298	623	22	5	843	5	TNFSF10	3	172241153	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	49204243	172241153	25781277	24	17540											
MUC4	4585	broad.mit.edu	37	chr3	195516064	195516064	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgtgcccgctgaggtggttCgtgaccctgaggaggccggt	17	11	0	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr3:195516064C>T	uc011bto.1	-	2	2847	c.2387G>A	c.(2386-2388)CGA>CAA	p.R796Q	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.R678Q	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	801	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGAGGTGGTTCGTGACCCTGA	0.602													T	195516064	T	T	195516064	3	4	246	1	0	0	0	0	1	0	0	0	9978	884	31	2		2	MUC4	3	195516064	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	23274911	195516064	2506366	25	17541											
SH3TC1	54436	broad.mit.edu	37	chr4	8233729	8233729	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgcgggccgtccagcggctgTgccacttctacagcgccgtc	13	16	1	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr4:8233729T>A	uc003gkv.3	+	13	3078	c.2977T>A	c.(2977-2979)TGC>AGC	p.C993S	SH3TC1_uc003gkw.3_Missense_Mutation_p.C917S|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	993							binding			large_intestine(2)|pancreas(1)	3						CCAGCGGCTGTGCCACTTCTA	0.642													A	8233729	A	A	8233729	3	1	246	1	0	0	0	0	1	0	0	0	14261	1696	59	5	3023	5	SH3TC1	4	8233729	Missense_Mutation	SNP	T	TCGA-41-3392-01A-01D-1495-08		8233729	182920547	26	17542											
CPEB2	132864	broad.mit.edu	37	chr4	15060838	15060838	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tacgtccttggaatttaagtGatagtgattttgtaatggat	10	3	0	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr4:15060838G>A	uc003gni.1	+	9	1360	c.1273G>A	c.(1273-1275)GAT>AAT	p.D425N	CPEB2_uc003gnj.1_Missense_Mutation_p.D395N|CPEB2_uc003gnk.1_Missense_Mutation_p.D433N|CPEB2_uc003gnl.1_Missense_Mutation_p.D406N|CPEB2_uc003gnm.1_Missense_Mutation_p.D403N|CPEB2_uc003gnn.1_Missense_Mutation_p.D398N	NM_182485	NP_872291	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding	425					regulation of translation	cytoplasm	nucleotide binding|RNA binding			skin(1)	1						GAATTTAAGTGATAGTGATTT	0.373													A	15060838	A	A	15060838	3	1	246	1	0	0	0	0	1	0	0	0	3801	1290	45	3	2655	3	CPEB2	4	15060838	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	6827109	15060838	176093438	27	17543											
GABRA4	2557	broad.mit.edu	37	chr4	46979123	46979123	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atgaccatccatgggaaaatCcaccaatctcatgggacact	7	12	1	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr4:46979123C>T	uc003gxg.2	-	5	671	c.532G>A	c.(532-534)GAT>AAT	p.D178N		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	178	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATGGGAAAATCCACCAATCTC	0.333													T	46979123	T	T	46979123	3	4	246	1	0	0	0	0	1	0	0	0	6163	855	30	3	1152	3	GABRA4	4	46979123	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	31918285	46979123	144175153	28	17544											
SLC10A4	201780	broad.mit.edu	37	chr4	48490671	48490671	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtagtcagaatgtgcagctCtgtacagccattctaaaact	9	9	3	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr4:48490671C>T	uc003gyc.2	+	3	1248	c.1029C>T	c.(1027-1029)CTC>CTT	p.L343L	ZAR1_uc003gyd.2_5'Flank	NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	343	Cytoplasmic (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1						ATGTGCAGCTCTGTACAGCCA	0.473													T	48490671	T	T	48490671	2	4	246	1	0	0	0	0	0	0	0	1	14376	900	32	3		3	SLC10A4	4	48490671	Silent	SNP	C	TCGA-41-3392-01A-01D-1495-08	1511548	48490671	142663605	29	17545											
DNAH5	1767	broad.mit.edu	37	chr5	13886073	13886073	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcattaccccatctcttacCtgaactttcatttttgtaat	2	11	3	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr5:13886073C>T	uc003jfd.2	-	18	2785	c.2743G>A	c.(2743-2745)GCA>ACA	p.A915T		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	915	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CATCTCTTACCTGAACTTTCA	0.289									Kartagener_syndrome				T	13886073	T	T	13886073	3	4	246	1	0	0	0	0	1	0	0	0	4604	695	24	3	11379	3	DNAH5	5	13886073	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08		13886073	167029187	30	17546											
CD14	929	broad.mit.edu	37	chr5	140012230	140012230	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tccttgaggcgggagtacgcTagcacacgcagggcgcctac	14	13	0	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr5:140012230T>A	uc003lgi.1	-	2	693	c.339A>T	c.(337-339)CTA>CTT	p.L113L	CD14_uc003lgj.1_Silent_p.L113L	NM_000591	NP_000582	P08571	CD14_HUMAN	CD14 antigen precursor	113	LRR 2.				apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAGTACGCTAGCACACGCA	0.622													A	140012230	A	A	140012230	2	1	246	1	0	0	0	0	0	0	0	1	2964	1509	53	5		5	CD14	5	140012230	Silent	SNP	T	TCGA-41-3392-01A-01D-1495-08	126126157	140012230	40903030	31	17547											
PCDHA1	56147	broad.mit.edu	37	chr5	140166089	140166089	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gggtggcgtccaaaacacacAgggaccttctggaggtaaat	13	9	1	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr5:140166089A>G	uc003lhb.2	+	1	214	c.214A>G	c.(214-216)AGG>GGG	p.R72G	PCDHA1_uc003lha.2_Missense_Mutation_p.R72G|PCDHA1_uc003lgz.2_Missense_Mutation_p.R72G	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	72	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAACACACAGGGACCTTCT	0.592													G	140166089	G	G	140166089	3	3	246	1	0	0	0	0	1	0	0	0	11519	179	7	4	216	4	PCDHA1	5	140166089	Missense_Mutation	SNP	A	TCGA-41-3392-01A-01D-1495-08	153859	140166089	40749171	32	17548											
PCDHA13	56136	broad.mit.edu	37	chr5	140263838	140263838	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagcccgcgctgacggccaCggcaacggtgctgttgtcgc	15	14	0	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr5:140263838C>T	uc003lif.2	+	1	1985	c.1985C>T	c.(1984-1986)ACG>ATG	p.T662M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.T662M|PCDHA13_uc003lid.2_Missense_Mutation_p.T662M	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	662	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGACGGCCACGGCAACGGTG	0.701													T	140263838	T	T	140263838	3	4	246	1	0	0	0	0	1	0	0	0	11523	536	19	1	1987	1	PCDHA13	5	140263838	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	97749	140263838	40651422	33	17549											
ODZ2	57451	broad.mit.edu	37	chr5	167420177	167420177	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcttggctattttgctggcGtatttcataggtaagtcagg	11	7	3	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr5:167420177G>A	uc010jjd.2	+	5	1176	c.1176G>A	c.(1174-1176)GCG>GCA	p.A392A	ODZ2_uc003lzq.2_Silent_p.A271A|ODZ2_uc003lzr.3_Silent_p.A201A	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TTTTGCTGGCGTATTTCATAG	0.537													A	167420177	A	A	167420177	2	1	246	1	0	0	0	0	0	0	0	1	10835	1132	40	1		1	ODZ2	5	167420177	Silent	SNP	G	TCGA-41-3392-01A-01D-1495-08	27156339	167420177	13495083	34	17550											
SLIT3	6586	broad.mit.edu	37	chr5	168149967	168149967	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggtgagacatgttactgaaGgtgtaattggtcagcatgct	13	5	1	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr5:168149967G>T	uc003mab.2	-	22	2802	c.2382C>A	c.(2380-2382)ACC>ACA	p.T794T	SLIT3_uc010jjg.2_Silent_p.T794T	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	794	LRR 18.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTTACTGAAGGTGTAATTGG	0.478													T	168149967	T	T	168149967	2	4	246	1	0	0	0	0	0	0	0	1	14741	987	35	5		5	SLIT3	5	168149967	Silent	SNP	G	TCGA-41-3392-01A-01D-1495-08	729790	168149967	12765293	35	17551											
MAS1L	116511	broad.mit.edu	37	chr6	29455303	29455303	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctgtaagaaccccactgccGagcagcaaagatagatcacg	9	13	1	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr6:29455303G>A	uc011dlq.1	-	1	377	c.377C>T	c.(376-378)TCG>TTG	p.S126L		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	126	Helical; Name=2; (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						CCCCACTGCCGAGCAGCAAAG	0.502													A	29455303	A	A	29455303	3	1	246	1	0	0	0	0	1	0	0	0	9321	1059	37	2	761	2	MAS1L	6	29455303	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08		29455303	141659764	36	17552											
SKIV2L	6499	broad.mit.edu	37	chr6	31937127	31937127	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcttgtggcctgaaccagaCggtggaggaatttgtggggg	19	6	0	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr6:31937127C>T	uc003nyn.1	+	27	3859	c.3470C>T	c.(3469-3471)ACG>ATG	p.T1157M	SKIV2L_uc011dou.1_Missense_Mutation_p.T999M|SKIV2L_uc011dov.1_Missense_Mutation_p.T964M|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	1157						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CTGAACCAGACGGTGGAGGAA	0.557													T	31937127	T	T	31937127	3	4	246	1	0	0	0	0	1	0	0	0	14359	536	19	1	3576	1	SKIV2L	6	31937127	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	2481824	31937127	139177940	37	17553											
NOTCH4	4855	broad.mit.edu	37	chr6	32165183	32165183	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaaggaggcggcgggcagCggttggccgggagaatcggg	21	9	1	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr6:32165183C>T	uc003obb.2	-	27	5084	c.4945G>A	c.(4945-4947)GCT>ACT	p.A1649T	GPSM3_uc003oaz.2_5'Flank|NOTCH4_uc011dpt.1_Missense_Mutation_p.A58T|NOTCH4_uc003oba.2_Missense_Mutation_p.A309T|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_Missense_Mutation_p.A58T	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1649	Cytoplasmic (Potential).|ANK 1.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CGGCGGGCAGCGGTTGGCCGG	0.697													T	32165183	T	T	32165183	3	4	246	1	0	0	0	0	1	0	0	0	10551	768	27	1	1082	1	NOTCH4	6	32165183	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	228056	32165183	138949884	38	17554											
CD164	8763	broad.mit.edu	37	chr6	109690088	109690088	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aatttcgttctttagatttgCagaatttataaagaaagaaa	6	3	1	4			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr6:109690088C>A	uc003pte.2	-	6	741	c.560G>T	c.(559-561)TGC>TTC	p.C187F	CD164_uc003ptd.2_Intron|CD164_uc003ptf.2_Missense_Mutation_p.C168F|CD164_uc011eap.1_Intron|CD164_uc010kdn.2_Missense_Mutation_p.C174F	NM_006016	NP_006007	Q04900	MUC24_HUMAN	CD164 molecule, sialomucin isoform 1	187	Cytoplasmic (Potential).				hemopoiesis|heterophilic cell-cell adhesion|immune response|muscle organ development|negative regulation of cell adhesion|negative regulation of cell proliferation|signal transduction	endosome membrane|extracellular region|integral to plasma membrane|lysosomal membrane	protein binding				0		all_cancers(87;4.65e-22)|all_epithelial(87;2.54e-20)|all_lung(197;1.6e-05)|Lung NSC(302;2.92e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.0175)		Epithelial(106;7.83e-46)|all cancers(137;1.15e-45)|OV - Ovarian serous cystadenocarcinoma(136;2.89e-26)|BRCA - Breast invasive adenocarcinoma(108;0.00128)|GBM - Glioblastoma multiforme(226;0.16)		TTTAGATTTGCAGAATTTATA	0.383													A	109690088	A	A	109690088	3	1	246	1	0	0	0	0	1	0	0	0	2969	710	25	5	88	5	CD164	6	109690088	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	77524905	109690088	61424979	39	17555											
ROS1	6098	broad.mit.edu	37	chr6	117686282	117686282	+	Frame_Shift_Del	DEL	G	-	-													cctttccccagtaggtataaGgagtgacagaaagattaaat							TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr6:117686282delG	uc003pxp.1	-	20	3258	c.3059delC	c.(3058-3060)CCTfs	p.P1020fs	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1020	Fibronectin type-III 4.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTAGGTATAAGGAGTGACAGA	0.393			T	GOPC|ROS1	glioblastoma|NSCLC								-	117686282	-	-	117686282	7	5	246	1	0	1	0	1	0	0	0	0	13531	1000	35	0	4080	0	ROS1	6	117686282	Frame_Shift_Del	DEL	G	TCGA-41-3392-01A-01D-1495-08	7996194	117686282	53428785	40	17556											
LFNG	3955	broad.mit.edu	37	chr7	2559902	2559902	+	Frame_Shift_Del	DEL	C	-	-													cctcgacctgctgctggagaCctggatctcgcgccacaagg							TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr7:2559902delC	uc003smf.2	+	1	424	c.407delC	c.(406-408)ACCfs	p.T136fs	LFNG_uc003smg.2_Frame_Shift_Del_p.T136fs	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	136	Lumenal (Potential).				organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		CTGCTGGAGACCTGGATCTCG	0.562													-	2559902	-	-	2559902	7	5	246	1	0	1	0	1	0	0	0	0	8737	507	18	0	685	0	LFNG	7	2559902	Frame_Shift_Del	DEL	C	TCGA-41-3392-01A-01D-1495-08		2559902	156578761	41	17557											
DYNC1I1	1780	broad.mit.edu	37	chr7	95664970	95664970	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaataagtccaagcctgtcGctgttaccggaatggctttc	9	11	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr7:95664970G>A	uc003uoc.3	+	13	1598	c.1321G>A	c.(1321-1323)GCT>ACT	p.A441T	DYNC1I1_uc003uod.3_Missense_Mutation_p.A424T|DYNC1I1_uc003uob.2_Missense_Mutation_p.A404T|DYNC1I1_uc003uoe.3_Missense_Mutation_p.A421T|DYNC1I1_uc010lfl.2_Missense_Mutation_p.A430T	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	441	WD 4.				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CAAGCCTGTCGCTGTTACCGG	0.498													A	95664970	A	A	95664970	3	1	246	1	0	0	0	0	1	0	0	0	4842	1087	38	1	1367	1	DYNC1I1	7	95664970	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	93105068	95664970	63473693	42	17558											
RBM28	55131	broad.mit.edu	37	chr7	127964701	127964701	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcctcatcacgggtcaccGccaagtcaaccttgagctgc	9	16	4	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr7:127964701G>A	uc003vmp.2	-	12	1365	c.1250C>T	c.(1249-1251)GCG>GTG	p.A417V	RBM28_uc003vmo.2_Missense_Mutation_p.A34V|RBM28_uc011koj.1_Missense_Mutation_p.A276V|RBM28_uc011kok.1_Missense_Mutation_p.A364V	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	417	RRM 3.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						ACGGGTCACCGCCAAGTCAAC	0.488													A	127964701	A	A	127964701	3	1	246	1	0	0	0	0	1	0	0	0	13128	1087	38	1	1061	1	RBM28	7	127964701	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	32299731	127964701	31173962	43	17559											
AHCYL2	23382	broad.mit.edu	37	chr7	129040182	129040182	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagatgacttttggtggtGtatcgatagatgtgtgaatg	14	2	0	5			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr7:129040182G>A	uc011kov.1	+	6	929	c.875G>A	c.(874-876)TGT>TAT	p.C292Y	AHCYL2_uc003vot.2_Missense_Mutation_p.C291Y|AHCYL2_uc003vov.2_Missense_Mutation_p.C189Y|AHCYL2_uc011kow.1_Missense_Mutation_p.C190Y|AHCYL2_uc011kox.1_Missense_Mutation_p.C189Y	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	292					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						TTTTGGTGGTGTATCGATAGA	0.463													A	129040182	A	A	129040182	3	1	246	1	0	0	0	0	1	0	0	0	411	1377	48	3	1019	3	AHCYL2	7	129040182	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	1075481	129040182	30098481	44	17560											
DPP6	1804	broad.mit.edu	37	chr7	154561187	154561187	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggatggcacgagactcgcctAcgccgccatcaatgattccc	10	15	1	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr7:154561187A>G	uc003wlk.2	+	9	1073	c.944A>G	c.(943-945)TAC>TGC	p.Y315C	DPP6_uc003wli.2_Missense_Mutation_p.Y251C|DPP6_uc003wlm.2_Missense_Mutation_p.Y253C|DPP6_uc011kvq.1_Missense_Mutation_p.Y208C	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	315	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGACTCGCCTACGCCGCCATC	0.527													G	154561187	G	G	154561187	3	3	246	1	0	0	0	0	1	0	0	0	4730	391	14	4	1094	4	DPP6	7	154561187	Missense_Mutation	SNP	A	TCGA-41-3392-01A-01D-1495-08	25521005	154561187	4577476	45	17561											
ZFAT	57623	broad.mit.edu	37	chr8	135622736	135622736	+	Nonsense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gaattgcttcgtgtgcagttAaaaccacacttatgatgggt	10	7	0	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr8:135622736A>T	uc003yup.2	-	4	786	c.611T>A	c.(610-612)TTA>TAA	p.L204*	ZFAT_uc003yun.2_Nonsense_Mutation_p.L192*|ZFAT_uc003yuo.2_Nonsense_Mutation_p.L192*|ZFAT_uc010meh.2_Nonsense_Mutation_p.L192*|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Nonsense_Mutation_p.L192*|ZFAT_uc010mej.2_Intron|ZFAT_uc003yur.2_Nonsense_Mutation_p.L192*	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GTGTGCAGTTAAAACCACACT	0.502													T	135622736	T	T	135622736	4	4	246	1	0	0	0	0	0	1	0	0	17629	372	13	5	3172	5	ZFAT	8	135622736	Nonsense_Mutation	SNP	A	TCGA-41-3392-01A-01D-1495-08		135622736	10741286	46	17562											
MORN5	254956	broad.mit.edu	37	chr9	124936831	124936831	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaatccccaagggctattacGattgtggagacggcttctat	10	9	1	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr9:124936831G>A	uc004blw.2	+	4	426	c.364G>A	c.(364-366)GAT>AAT	p.D122N	MORN5_uc011lyn.1_Missense_Mutation_p.D122N|MORN5_uc011lyo.1_Silent_p.T84T	NM_198469	NP_940871	Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	122											0						GGGCTATTACGATTGTGGAGA	0.463													A	124936831	A	A	124936831	3	1	246	1	0	0	0	0	1	0	0	0	9711	1058	37	2	378	2	MORN5	9	124936831	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08		124936831	16276600	47	17563											
ADARB2	105	broad.mit.edu	37	chr10	1263025	1263025	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcttggtgcgcaggtgcccGcggaacttcctgacgaggtg	15	11	1	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr10:1263025G>A	uc009xhq.2	-	7	1922	c.1548C>T	c.(1546-1548)CGC>CGT	p.R516R		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	516	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GCAGGTGCCCGCGGAACTTCC	0.657													A	1263025	A	A	1263025	2	1	246	1	0	0	0	0	0	0	0	1	283	1074	38	1		1	ADARB2	10	1263025	Silent	SNP	G	TCGA-41-3392-01A-01D-1495-08		1263025	134271722	48	17564											
HPSE2	60495	broad.mit.edu	37	chr10	100249866	100249866	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtcccggatcactcggccagGccgtggcttccgctggagcc	14	16	1	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr10:100249866G>T	uc001kpn.1	-	10	1468	c.1408C>A	c.(1408-1410)CCT>ACT	p.P470T	HPSE2_uc009xwc.1_Missense_Mutation_p.P460T|HPSE2_uc001kpo.1_Missense_Mutation_p.P402T|HPSE2_uc009xwd.1_Missense_Mutation_p.P348T	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	470					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		ACTCGGCCAGGCCGTGGCTTC	0.562													T	100249866	T	T	100249866	3	4	246	1	0	0	0	0	1	0	0	0	7345	1203	42	5	420	5	HPSE2	10	100249866	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	98986841	100249866	35284881	49	17565											
TPH1	7166	broad.mit.edu	37	chr11	18047154	18047154	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaacagcctcctctgaagCgccaagagaagccaagccaa	9	13	1	3	rs145855109	byFrequency	TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr11:18047154C>T	uc001mnp.2	-	7	924	c.898G>A	c.(898-900)GCT>ACT	p.A300T	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	300					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	TCCTCTGAAGCGCCAAGAGAA	0.438													T	18047154	T	T	18047154	3	4	246	1	0	0	0	0	1	0	0	0	16398	768	27	1	452	1	TPH1	11	18047154	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08		18047154	116959362	50	17566											
OR5B17	219965	broad.mit.edu	37	chr11	58126152	58126152	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgtgttgtcatggtggtggTataatgtagggggttacaca	15	4	1	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr11:58126152T>C	uc010rke.1	-	1	391	c.391A>G	c.(391-393)ACC>GCC	p.T131A		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ATGGTGGTGGTATAATGTAGG	0.448													C	58126152	C	C	58126152	3	2	246	1	0	0	0	0	1	0	0	0	11149	1638	57	4	555	4	OR5B17	11	58126152	Missense_Mutation	SNP	T	TCGA-41-3392-01A-01D-1495-08	40078998	58126152	76880364	51	17567											
CD6	923	broad.mit.edu	37	chr11	60786743	60786743	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cagggtcccccagccctcagCctgactccaccgacaacgat	8	19	1	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr11:60786743C>G	uc001nqq.2	+	13	2183	c.1960C>G	c.(1960-1962)CCT>GCT	p.P654A	CD6_uc001nqr.2_Missense_Mutation_p.P587A|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.P578A	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	654	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						CAGCCCTCAGCCTGACTCCAC	0.657													G	60786743	G	G	60786743	3	3	246	1	0	0	0	0	1	0	0	0	3028	739	26	5	2010	5	CD6	11	60786743	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	2660591	60786743	74219773	52	17568											
CALCOCO1	57658	broad.mit.edu	37	chr12	54117525	54117525	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggccctggcggttcacatatCggaactggtagagctgagct	14	10	1	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr12:54117525C>T	uc001sef.2	-	4	446	c.302G>A	c.(301-303)CGA>CAA	p.R101Q	CALCOCO1_uc010som.1_Intron|CALCOCO1_uc010son.1_5'UTR|CALCOCO1_uc001seh.2_Missense_Mutation_p.R101Q|CALCOCO1_uc009znd.2_Missense_Mutation_p.R101Q|CALCOCO1_uc001seg.2_Intron|CALCOCO1_uc010soo.1_Missense_Mutation_p.R94Q	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	101	N-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						GTTCACATATCGGAACTGGTA	0.602													T	54117525	T	T	54117525	3	4	246	1	0	0	0	0	1	0	0	0	2577	884	31	2	1821	2	CALCOCO1	12	54117525	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08		54117525	79734370	53	17569											
HOXC11	3227	broad.mit.edu	37	chr12	54369092	54369092	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagctgtcccggatgctgaaCctgacggaccgacaagtgaa	12	12	0	3	rs141170619		TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr12:54369092C>T	uc001sem.2	+	2	926	c.810C>T	c.(808-810)AAC>AAT	p.N270N		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	270	Homeobox.				endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGATGCTGAACCTGACGGACC	0.478			T	NUP98	AML								T	54369092	T	T	54369092	2	4	246	1	0	0	0	0	0	0	0	1	7310	506	18	3		3	HOXC11	12	54369092	Silent	SNP	C	TCGA-41-3392-01A-01D-1495-08	251567	54369092	79482803	54	17570											
OR6C4	341418	broad.mit.edu	37	chr12	55945591	55945591	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctcagacacaagcctcttagAactgatggtcatcctcttgg	8	12	4	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr12:55945591A>G	uc010spp.1	+	1	581	c.581A>G	c.(580-582)GAA>GGA	p.E194G		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCCTCTTAGAACTGATGGTC	0.468													G	55945591	G	G	55945591	3	3	246	1	0	0	0	0	1	0	0	0	11193	246	9	4	583	4	OR6C4	12	55945591	Missense_Mutation	SNP	A	TCGA-41-3392-01A-01D-1495-08	1576499	55945591	77906304	55	17571											
B4GALNT1	2583	broad.mit.edu	37	chr12	58020574	58020574	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgtttgaagaagagcagccGgtgtttggccatctggctct	14	8	2	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr12:58020574G>A	uc001spg.1	-	11	1987	c.1555C>T	c.(1555-1557)CGG>TGG	p.R519W	B4GALNT1_uc010sru.1_Missense_Mutation_p.R464W	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	519	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			AAGAGCAGCCGGTGTTTGGCC	0.597													A	58020574	A	A	58020574	3	1	246	1	0	0	0	0	1	0	0	0	1266	1115	39	2	50	2	B4GALNT1	12	58020574	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	2074983	58020574	75831321	56	17572											
PHLDA1	22822	broad.mit.edu	37	chr12	76424413	76424413	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttggtgcggatgcgggtgcGggtgagggtgtgggtgcgag	24	4	0	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr12:76424413G>A	uc001sxu.2	-	1	1144	c.1109C>T	c.(1108-1110)CCG>CTG	p.P370L		NM_007350	NP_031376	Q8WV24	PHLA1_HUMAN	pleckstrin homology-like domain, family A,	370	14 X 2 AA repeats of P-H.				apoptosis	cytoplasmic vesicle membrane|nucleolus|plasma membrane	protein binding				0		Colorectal(145;0.09)				atgcgggtgcgggtgagggtg	0.139													A	76424413	A	A	76424413	3	1	246	1	0	0	0	0	1	0	0	0	11848	1116	39	2	100	2	PHLDA1	12	76424413	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	18403839	76424413	57427482	57	17573											
ACACB	32	broad.mit.edu	37	chr12	109665288	109665288	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	catgctgccgtcctcccaccCaaaccggtatggagtgggac	11	15	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr12:109665288C>A	uc001tob.2	+	28	4114	c.3995C>A	c.(3994-3996)CCA>CAA	p.P1332Q	ACACB_uc001toc.2_Missense_Mutation_p.P1332Q|ACACB_uc010sxl.1_5'Flank|ACACB_uc001tod.2_5'Flank|ACACB_uc010sxm.1_5'Flank	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1332					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TCCTCCCACCCAAACCGGTAT	0.587													A	109665288	A	A	109665288	3	1	246	1	0	0	0	0	1	0	0	0	107	594	21	5	4101	5	ACACB	12	109665288	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	33240875	109665288	24186607	58	17574											
C12orf51	283450	broad.mit.edu	37	chr12	112620944	112620944	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actctgatttactacagacaCggttagaatctcttctgttg	7	9	3	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr12:112620944C>G	uc009zwc.2	-	55	9658	c.9640G>C	c.(9640-9642)GTG>CTG	p.V3214L		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						ACTACAGACACGGTTAGAATC	0.353													G	112620944	G	G	112620944	3	3	246	1	0	0	0	0	1	0	0	0	1696	536	19	5	2410	5	C12orf51	12	112620944	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	2955656	112620944	21230951	59	17575											
CLYBL	171425	broad.mit.edu	37	chr13	100425263	100425263	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggagtggctgcaaacaaaaAggtaatggcatgattttagt	12	4	0	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr13:100425263A>C	uc001vok.2	+	2	262	c.248A>C	c.(247-249)AAG>ACG	p.K83T	CLYBL_uc010tix.1_Missense_Mutation_p.K83T|CLYBL_uc010tiy.1_Missense_Mutation_p.K83T	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	83					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCAAACAAAAAGGTAATGGCA	0.383													C	100425263	C	C	100425263	3	2	246	1	0	0	0	0	1	0	0	0	3573	86	3	5	254	5	CLYBL	13	100425263	Missense_Mutation	SNP	A	TCGA-41-3392-01A-01D-1495-08		100425263	14744615	60	17576											
OR11G2	390439	broad.mit.edu	37	chr14	20665689	20665689	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	agggaggggcagatcctcctCtttgtgctcttcactgttgt	12	10	3	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr14:20665689C>G	uc010tlb.1	+	1	195	c.195C>G	c.(193-195)CTC>CTG	p.L65L		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	65	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		AGATCCTCCTCTTTGTGCTCT	0.552													G	20665689	G	G	20665689	2	3	246	1	0	0	0	0	0	0	0	1	10925	900	32	5		5	OR11G2	14	20665689	Silent	SNP	C	TCGA-41-3392-01A-01D-1495-08		20665689	86683851	61	17577											
ESR2	2100	broad.mit.edu	37	chr14	64723980	64723980	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggagcaaagatgagcttgCcggggtggtcaattgagcgc	16	8	1	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr14:64723980C>T	uc001xha.1	-	6	1523	c.1055G>A	c.(1054-1056)GGC>GAC	p.G352D	ESR2_uc001xgu.2_Missense_Mutation_p.G352D|ESR2_uc001xgv.2_Missense_Mutation_p.G352D|ESR2_uc001xgw.2_Intron|ESR2_uc001xgx.2_Missense_Mutation_p.G352D|ESR2_uc001xgy.1_Missense_Mutation_p.G352D|ESR2_uc001xgz.1_Missense_Mutation_p.G352D|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Intron|ESR2_uc010aqd.1_RNA	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	352	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	GATGAGCTTGCCGGGGTGGTC	0.488													T	64723980	T	T	64723980	3	4	246	1	0	0	0	0	1	0	0	0	5257	739	26	3	639	3	ESR2	14	64723980	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	44058291	64723980	42625560	62	17578											
PLEKHH1	57475	broad.mit.edu	37	chr14	68035891	68035891	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtggccacatcgggcatgCggctctcagatatgtctccc	11	14	2	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr14:68035891C>T	uc001xjl.1	+	8	1442	c.1300C>T	c.(1300-1302)CGG>TGG	p.R434W	PLEKHH1_uc010tsw.1_Missense_Mutation_p.R2W|PLEKHH1_uc001xjm.1_5'Flank|PLEKHH1_uc001xjn.1_5'Flank	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	434						cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		ATCGGGCATGCGGCTCTCAGA	0.592													T	68035891	T	T	68035891	3	4	246	1	0	0	0	0	1	0	0	0	12076	759	27	1	1326	1	PLEKHH1	14	68035891	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	3311911	68035891	39313649	63	17579											
ADAM20	8748	broad.mit.edu	37	chr14	70989515	70989515	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gggtgcccattcatggttgcAgtgacagtgttgtttgttgt	14	6	1	1	rs113965969		TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr14:70989515A>T	uc001xme.2	-	2	2355	c.2110T>A	c.(2110-2112)TGC>AGC	p.C704S		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	654	EGF-like.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TCATGGTTGCAGTGACAGTGT	0.483													T	70989515	T	T	70989515	3	4	246	1	0	0	0	0	1	0	0	0	242	188	7	5	224	5	ADAM20	14	70989515	Missense_Mutation	SNP	A	TCGA-41-3392-01A-01D-1495-08	2953624	70989515	36360025	64	17580											
ACOT4	122970	broad.mit.edu	37	chr14	74058995	74058995	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagttggaggtgctggacgGccacgaccccgagcctggac	17	12	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr14:74058995G>A	uc001xoo.2	+	1	586	c.332G>A	c.(331-333)GGC>GAC	p.G111D		NM_152331	NP_689544	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	111					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)		GTGCTGGACGGCCACGACCCC	0.682													A	74058995	A	A	74058995	3	1	246	1	0	0	0	0	1	0	0	0	153	1203	42	3	334	3	ACOT4	14	74058995	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	3069480	74058995	33290545	65	17581											
HERC2	8924	broad.mit.edu	37	chr15	28514552	28514553	+	Frame_Shift_Ins	INS	-	C	C													tagtatttccatcctattaaINScccccaacctatgacctctt							TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr15:28514552_28514553insC	uc001zbj.2	-	11	1393_1394	c.1287_1288insG	c.(1285-1290)GGGTTAfs	p.G429fs	HERC2_uc001zbl.1_Frame_Shift_Ins_p.G124fs	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	429_430					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CATCCTATTAACCCCCAACCTA	0.436													C	28514553	C	C	28514552	7	5	246	1	0	1	1	0	0	0	0	0	7058	40	2	0	13548	0	HERC2	15	28514552	Frame_Shift_Ins	INS	-	TCGA-41-3392-01A-01D-1495-08		28514552	74016840	66	17582											
RASGRF1	5923	broad.mit.edu	37	chr15	79296158	79296158	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actcactctgcttgctgagcGctgaagggtcttcgggcttc	12	12	3	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr15:79296158G>A	uc002beq.2	-	16	2858	c.2483C>T	c.(2482-2484)GCG>GTG	p.A828V	RASGRF1_uc002bep.2_Missense_Mutation_p.A812V|RASGRF1_uc010blm.1_Missense_Mutation_p.A737V|RASGRF1_uc002ber.3_Missense_Mutation_p.A812V|RASGRF1_uc010unh.1_Missense_Mutation_p.A223V|RASGRF1_uc002beo.2_Missense_Mutation_p.A44V	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	830					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						CTTGCTGAGCGCTGAAGGGTC	0.637													A	79296158	A	A	79296158	3	1	246	1	0	0	0	0	1	0	0	0	13072	1087	38	1	1390	1	RASGRF1	15	79296158	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	50781606	79296158	23235234	67	17583											
PHLPP2	23035	broad.mit.edu	37	chr16	71689260	71689260	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggcgcgggagctcctcatttCggtctccatcaaacatgcca	10	14	3	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr16:71689260C>T	uc002fax.2	-	16	2474	c.2468G>A	c.(2467-2469)CGA>CAA	p.R823Q	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Missense_Mutation_p.R756Q	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	823	PP2C-like.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						CTCCTCATTTCGGTCTCCATC	0.483													T	71689260	T	T	71689260	3	4	246	1	0	0	0	0	1	0	0	0	11855	884	31	2	1515	2	PHLPP2	16	71689260	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08		71689260	18665493	68	17584											
CDH15	1013	broad.mit.edu	37	chr16	89256722	89256722	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgaggccccgctgcaggcGgctgcccttagggctgagcg	16	13	0	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr16:89256722G>A	uc002fmt.2	+	8	1127	c.1050G>A	c.(1048-1050)GCG>GCA	p.A350A		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	350	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CGCTGCAGGCGGCTGCCCTTA	0.637													A	89256722	A	A	89256722	2	1	246	1	0	0	0	0	0	0	0	1	3100	1103	39	2		2	CDH15	16	89256722	Silent	SNP	G	TCGA-41-3392-01A-01D-1495-08	17567462	89256722	1098031	69	17585											
NF1	4763	broad.mit.edu	37	chr17	29550520	29550543	+	In_Frame_Del	DEL	ACAGAAATTCTCAAGTGGTTGCGG	-	-													gtcatcaaatgcttagtagcAcagaaattctcaagtggttg							TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr17:29550520_29550543delACAGAAATTCTCAAGTGGTTGCGG	uc002hgg.2	+	16	2113_2136	c.1780_1803delACAGAAATTCTCAAGTGGTTGCGG	c.(1780-1803)ACAGAAATTCTCAAGTGGTTGCGGdel	p.TEILKWLR594del	NF1_uc002hgh.2_In_Frame_Del_p.TEILKWLR594del|NF1_uc010csn.1_In_Frame_Del_p.TEILKWLR454del|NF1_uc002hgi.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	594_601					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GCTTAGTAGCACAGAAATTCTCAAGTGGTTGCGGGAAATATTGA	0.312			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29550543	-	-	29550520	7	5	246	1	0	1	0	1	0	0	0	0	10356	159	6	0	1903	0	NF1	17	29550520	In_Frame_Del	DEL	ACAGAAATTCTCAAGTGGTTGCGG	TCGA-41-3392-01A-01D-1495-08		29550520	51644690	70	17586											
CARD14	79092	broad.mit.edu	37	chr17	78157817	78157817	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaggaggtgctgctgcggcGgtgccagcagctgcaggagc	19	10	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr17:78157817G>A	uc002jxw.1	+	4	650	c.455G>A	c.(454-456)CGG>CAG	p.R152Q	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.R152Q|CARD14_uc010wud.1_RNA	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	152	Potential.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CTGCTGCGGCGGTGCCAGCAG	0.667													A	78157817	A	A	78157817	3	1	246	1	0	0	0	0	1	0	0	0	2646	1116	39	2	465	2	CARD14	17	78157817	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	48607297	78157817	3037393	71	17587											
BAIAP2	10458	broad.mit.edu	37	chr17	79080620	79080620	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccatcccaccccccgattaCggcgccgcctcccgggcctt	9	22	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr17:79080620C>T	uc002jzg.2	+	12	1521	c.1413C>T	c.(1411-1413)TAC>TAT	p.Y471Y	BAIAP2_uc002jyz.3_Silent_p.Y471Y|BAIAP2_uc002jza.2_Silent_p.Y471Y|BAIAP2_uc002jzc.2_Silent_p.Y472Y|BAIAP2_uc002jzb.2_Silent_p.Y228Y|BAIAP2_uc002jzd.2_Silent_p.Y471Y|BAIAP2_uc002jzf.2_Silent_p.Y471Y|BAIAP2_uc002jze.2_Silent_p.Y504Y|BAIAP2_uc010wuh.1_Silent_p.Y393Y|BAIAP2_uc002jzh.2_Silent_p.Y472Y|BAIAP2_uc010wui.1_Silent_p.Y334Y	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	471					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CCCCCGATTACGGCGCCGCCT	0.697													T	79080620	T	T	79080620	2	4	246	1	0	0	0	0	0	0	0	1	1301	547	19	1		1	BAIAP2	17	79080620	Silent	SNP	C	TCGA-41-3392-01A-01D-1495-08	922803	79080620	2114590	72	17588											
FECH	2235	broad.mit.edu	37	chr18	55230200	55230200	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatagtatctgtaaatggcaTttaagctgctgcctgaaata	8	6	1	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr18:55230200T>C	uc002lgq.3	-	6	728	c.611A>G	c.(610-612)AAT>AGT	p.N204S	FECH_uc002lgp.3_Missense_Mutation_p.N210S|FECH_uc002lgr.3_Missense_Mutation_p.N62S	NM_000140	NP_000131	P22830	HEMH_HUMAN	ferrochelatase isoform b precursor	204					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)	1		Colorectal(73;0.227)				GTAAATGGCATTTAAGCTGCT	0.408													C	55230200	C	C	55230200	3	2	246	1	0	0	0	0	1	0	0	0	5808	1493	52	4	684	4	FECH	18	55230200	Missense_Mutation	SNP	T	TCGA-41-3392-01A-01D-1495-08		55230200	22847048	73	17589											
ZNF236	7776	broad.mit.edu	37	chr18	74635065	74635065	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggagaaaagccatacaaatGtgatgaatgtggaaagagtt	12	3	0	4			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr18:74635065G>A	uc002lmi.2	+	21	3788	c.3590G>A	c.(3589-3591)TGT>TAT	p.C1197Y	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1197	C2H2-type 23.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCATACAAATGTGATGAATGT	0.368													A	74635065	A	A	74635065	3	1	246	1	0	0	0	0	1	0	0	0	17786	1377	48	3	3672	3	ZNF236	18	74635065	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	19404865	74635065	3442183	74	17590											
PLIN4	729359	broad.mit.edu	37	chr19	4511216	4511216	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cggtcaggacagtcttgctgGtgtccacgccggtctggaca	14	12	3	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr19:4511216G>T	uc002mar.1	-	3	2714	c.2714C>A	c.(2713-2715)ACC>AAC	p.T905N	PLIN4_uc010dub.1_5'UTR	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	905	27 X 33 AA approximate tandem repeat.|25.					lipid particle|plasma membrane					0						AGTCTTGCTGGTGTCCACGCC	0.577													T	4511216	T	T	4511216	3	4	246	1	0	0	0	0	1	0	0	0	12092	1261	44	5	1375	5	PLIN4	19	4511216	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08		4511216	54617767	75	17591											
CYP4F8	11283	broad.mit.edu	37	chr19	15728930	15728930	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aacttgtgccaccctgacatCgtccgatctgtcatcaatac	6	14	3	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr19:15728930C>T	uc002nbi.2	+	3	382	c.318C>T	c.(316-318)ATC>ATT	p.I106I	CYP4F8_uc010xoi.1_Silent_p.I106I|CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	106					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						ACCCTGACATCGTCCGATCTG	0.567													T	15728930	T	T	15728930	2	4	246	1	0	0	0	0	0	0	0	1	4191	874	31	2		2	CYP4F8	19	15728930	Silent	SNP	C	TCGA-41-3392-01A-01D-1495-08	11217714	15728930	43400053	76	17592											
KCNA7	3743	broad.mit.edu	37	chr19	49573469	49573469	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gctgaacatcccagcctcttCgccctctgtctcccggtgat	8	17	3	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr19:49573469C>T	uc002pmg.2	-	2	1578	c.1222G>A	c.(1222-1224)GAA>AAA	p.E408K		NM_031886	NP_114092	Q96RP8	KCNA7_HUMAN	potassium voltage-gated channel, shaker-related	408						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)	1		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000397)|OV - Ovarian serous cystadenocarcinoma(262;0.000519)|GBM - Glioblastoma multiforme(486;0.00541)|Epithelial(262;0.0441)		CCAGCCTCTTCGCCCTCTGTC	0.597													T	49573469	T	T	49573469	3	4	246	1	0	0	0	0	1	0	0	0	8008	893	31	2	152	2	KCNA7	19	49573469	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	33844539	49573469	9555514	77	17593											
RPL13A	23521	broad.mit.edu	37	chr19	49994303	49994303	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctttctctaacagaaaaagCggatggtggttcctgctgcc	10	10	2	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr19:49994303C>T	uc002pny.2	+	6	371	c.349C>T	c.(349-351)CGG>TGG	p.R117W	RPL13A_uc002pnz.2_Missense_Mutation_p.R56W|RPL13A_uc002poa.2_Missense_Mutation_p.R107W|SNORD35A_uc010enb.1_5'Flank	NM_012423	NP_036555	P40429	RL13A_HUMAN	ribosomal protein L13a	117					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		ACAGAAAAAGCGGATGGTGGT	0.562													T	49994303	T	T	49994303	3	4	246	1	0	0	0	0	1	0	0	0	13560	759	27	1	371	1	RPL13A	19	49994303	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	420834	49994303	9134680	78	17594											
PRPF31	26121	broad.mit.edu	37	chr19	54627985	54627985	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcgtctacctcagtgctgCcccacaccggctacatctac	6	18	4	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr19:54627985C>T	uc002qdh.2	+	8	1201	c.805C>T	c.(805-807)CCC>TCC	p.P269S	PRPF31_uc010yek.1_Missense_Mutation_p.P269S	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	269	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CTCAGTGCTGCCCCACACCGG	0.672													T	54627985	T	T	54627985	3	4	246	1	0	0	0	0	1	0	0	0	12566	739	26	3	831	3	PRPF31	19	54627985	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08	4633682	54627985	4500998	79	17595											
PPP1R12C	54776	broad.mit.edu	37	chr19	55603589	55603589	+	Splice_Site	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccctggcctcggcgcccttaCctgcgtggcccgctccagct	11	20	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr19:55603589C>G	uc002qix.2	-	19	2176	c.2160_splice	c.e19+1	p.Q720_splice	PPP1R12C_uc010yfs.1_Splice_Site_p.Q645_splice|PPP1R12C_uc002qiy.2_Splice_Site_p.Q718_splice	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C							cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		GGCGCCCTTACCTGCGTGGCC	0.721													G	55603589	G	G	55603589	5	3	246	1	0	0	0	0	0	0	1	0	12356	521	18	5	203	5	PPP1R12C	19	55603589	Splice_Site	SNP	C	TCGA-41-3392-01A-01D-1495-08	975604	55603589	3525394	80	17596											
PTPRT	11122	broad.mit.edu	37	chr20	41100999	41100999	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccggatggtcatgaaggggcGcaggcctcgcagggtgtagt	18	9	1	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr20:41100999G>A	uc002xkg.2	-	8	1541	c.1357C>T	c.(1357-1359)CGC>TGC	p.R453C	PTPRT_uc010ggj.2_Missense_Mutation_p.R453C	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	453	Extracellular (Potential).|Fibronectin type-III 2.		R -> C (in a gastric cancer).		homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATGAAGGGGCGCAGGCCTCGC	0.607													A	41100999	A	A	41100999	3	1	246	1	0	0	0	0	1	0	0	0	12812	1087	38	1	3125	1	PTPRT	20	41100999	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08		41100999	21924521	81	17597											
SLC13A3	64849	broad.mit.edu	37	chr20	45204315	45204315	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcagcaagggctctgtctctGtgttgggagctgggcagaga	16	8	3	1			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr20:45204315G>C	uc002xsf.1	-	10	1267	c.1229C>G	c.(1228-1230)ACA>AGA	p.T410R	SLC13A3_uc010ghn.1_Missense_Mutation_p.T379R|SLC13A3_uc010zxw.1_Missense_Mutation_p.T360R|SLC13A3_uc002xsg.1_Missense_Mutation_p.T363R|SLC13A3_uc010gho.1_Missense_Mutation_p.T328R|SLC13A3_uc010zxx.1_Missense_Mutation_p.T312R|SLC13A3_uc010zxv.1_Intron	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	410	Cytoplasmic (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CTCTGTCTCTGTGTTGGGAGC	0.622													C	45204315	C	C	45204315	3	2	246	1	0	0	0	0	1	0	0	0	14393	1377	48	5	595	5	SLC13A3	20	45204315	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08	4103316	45204315	17821205	82	17598											
KRTAP10-1	386677	broad.mit.edu	37	chr21	45959481	45959481	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcttgcaacggacgggcaCgcagcaggcctgctggcagg	17	12	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr21:45959481C>T	uc002zfh.1	-	1	598	c.553G>A	c.(553-555)GTG>ATG	p.V185M	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198691	NP_941964	P60331	KR101_HUMAN	keratin associated protein 10-1	185	16.|24 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						CGGACGGGCACGCAGCAGGCC	0.627													T	45959481	T	T	45959481	3	4	246	1	0	0	0	0	1	0	0	0	8505	536	19	1	299	1	KRTAP10-1	21	45959481	Missense_Mutation	SNP	C	TCGA-41-3392-01A-01D-1495-08		45959481	2170414	83	17599											
RIMBP3	85376	broad.mit.edu	37	chr22	20458153	20458153	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacccgcgcccggtagtgcGtgccggggcacaggccctgg	16	17	0	0			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr22:20458153G>A	uc002zsd.3	-	1	3634	c.3149C>T	c.(3148-3150)ACG>ATG	p.T1050M		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			CCGGTAGTGCGTGCCGGGGCA	0.642													A	20458153	A	A	20458153	3	1	246	1	0	0	0	0	1	0	0	0	13364	1145	40	1	1774	1	RIMBP3	22	20458153	Missense_Mutation	SNP	G	TCGA-41-3392-01A-01D-1495-08		20458153	30846413	84	17600											
CABIN1	23523	broad.mit.edu	37	chr22	24439394	24439394	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctggactccacagatgtcaAcctctggtataagattggac	10	10	2	2			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr22:24439394A>G	uc002zzi.1	+	6	501	c.374A>G	c.(373-375)AAC>AGC	p.N125S	CABIN1_uc002zzj.1_Missense_Mutation_p.N125S|CABIN1_uc002zzl.1_Missense_Mutation_p.N125S|CABIN1_uc010guk.1_Missense_Mutation_p.N80S|CABIN1_uc002zzk.1_Missense_Mutation_p.N80S	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	125	TPR 3.				cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ACAGATGTCAACCTCTGGTAT	0.443													G	24439394	G	G	24439394	3	3	246	1	0	0	0	0	1	0	0	0	2528	43	2	4	392	4	CABIN1	22	24439394	Missense_Mutation	SNP	A	TCGA-41-3392-01A-01D-1495-08	3981241	24439394	26865172	85	17601											
MAPK8IP2	23542	broad.mit.edu	37	chr22	51042339	51042340	+	Frame_Shift_Del	DEL	GC	-	-													gtcgccagtgcgcccgggttGcgactgcgaagggaaccggc							TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chr22:51042339_51042340delGC	uc003bmx.2	+	5	728_729	c.611_612delGC	c.(610-612)TGCfs	p.C204fs	MAPK8IP2_uc003bmy.2_Frame_Shift_Del_p.C177fs|MAPK8IP2_uc011asc.1_5'Flank	NM_012324	NP_036456	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting	204	JNK-binding domain (JBD).				behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			large_intestine(2)|central_nervous_system(1)	3		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGCCCGGGTTGCGACTGCGAAG	0.743													-	51042340	-	-	51042339	7	5	246	1	0	1	0	1	0	0	0	0	9285	1319	46	0	719	0	MAPK8IP2	22	51042339	Frame_Shift_Del	DEL	GC	TCGA-41-3392-01A-01D-1495-08	26602945	51042339	262227	86	17602											
XKRX	402415	broad.mit.edu	37	chrX	100169504	100169504	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgaagccaatggaaatcagAtaagcaataatgagctgcaa	9	6	1	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chrX:100169504A>G	uc004egn.2	-	3	1778	c.1173T>C	c.(1171-1173)TAT>TAC	p.Y391Y	XKRX_uc011mre.1_Silent_p.Y187Y	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	391	Helical; (Potential).					integral to membrane|plasma membrane				breast(1)	1						TGGAAATCAGATAAGCAATAA	0.403													G	100169504	G	G	100169504	2	3	246	1	0	0	0	0	0	0	0	1	17436	340	12	4		4	XKRX	23	100169504	Silent	SNP	A	TCGA-41-3392-01A-01D-1495-08		100169504	55101056	87	17603											
SLITRK4	139065	broad.mit.edu	37	chrX	142718880	142718880	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atgtcagaatctgcatttgtCgaagaaatcagggctgacaa	10	7	3	3			TCGA-41-3392-01A-01D-1495-08	TCGA-41-3392-10A-01D-1495-08									Somatic	Phase_I	Capture				Illumina GAIIx	c08b37a5-9938-4ab0-8183-d73b01cb9a89	63bffde9-61a1-47e7-ab0b-701ee6f19fdb	g.chrX:142718880C>T	uc004fbx.2	-	2	421	c.45G>A	c.(43-45)TCG>TCA	p.S15S	SLITRK4_uc004fby.2_Silent_p.S15S	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	15						integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCATTTGTCGAAGAAATCA	0.388													T	142718880	T	T	142718880	2	4	246	1	0	0	0	0	0	0	0	1	14745	871	31	2		2	SLITRK4	23	142718880	Silent	SNP	C	TCGA-41-3392-01A-01D-1495-08	42549376	142718880	12551680	88	17604											
MEGF6	1953	broad.mit.edu	37	chr1	3412515	3412515	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggtgccggtcacagggtcGcaggccgccccctgcccaca	13	18	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:3412515G>A	uc001akl.2	-	30	4037	c.3810C>T	c.(3808-3810)TGC>TGT	p.C1270C	MEGF6_uc001akk.2_Silent_p.C1035C	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	1270	EGF-like 23.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TCACAGGGTCGCAGGCCGCCC	0.706													A	3412515	A	A	3412515	2	1	247	1	0	0	0	0	0	0	0	1	9462	1079	38	1		1	MEGF6	1	3412515	Silent	SNP	G	TCGA-41-3393-01A-01D-1353-08		3412515	245838106	1	17605											
KIAA0467	23334	broad.mit.edu	37	chr1	43909459	43909459	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccactgcggcccccctcaccCgcccgcaggtgagcccgtcc	10	23	1	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:43909459C>T	uc001cjk.1	+	47	6582	c.6120C>T	c.(6118-6120)CCC>CCT	p.P2040P	KIAA0467_uc001cjl.1_5'Flank	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2939						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCCCCTCACCCGCCCGCAGGT	0.572													T	43909459	T	T	43909459	2	4	247	1	0	0	0	0	0	0	0	1	8178	639	23	2		2	KIAA0467	1	43909459	Silent	SNP	C	TCGA-41-3393-01A-01D-1353-08	40496944	43909459	205341162	2	17606											
BARHL2	343472	broad.mit.edu	37	chr1	91182336	91182336	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttaattaaaaaagaagaCgtggaagtcctgggggccga	12	7	0	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:91182336C>T	uc001dns.2	-	1	459	c.417G>A	c.(415-417)ACG>ACA	p.T139T		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	139						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		AAAAAGAAGACGTGGAAGTCC	0.512													T	91182336	T	T	91182336	2	4	247	1	0	0	0	0	0	0	0	1	1314	523	19	1		1	BARHL2	1	91182336	Silent	SNP	C	TCGA-41-3393-01A-01D-1353-08	47272877	91182336	158068285	3	17607											
SLC6A17	388662	broad.mit.edu	37	chr1	110735165	110735165	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagggtaccttaacaccaacGtcctgagccgggacctcatc	9	14	1	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:110735165G>A	uc009wfq.2	+	8	1605	c.1144G>A	c.(1144-1146)GTC>ATC	p.V382I	SLC6A17_uc001dze.1_5'UTR	NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	382	Extracellular (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		TAACACCAACGTCCTGAGCCG	0.537													A	110735165	A	A	110735165	3	1	247	1	0	0	0	0	1	0	0	0	14680	1145	40	1	1170	1	SLC6A17	1	110735165	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	19552829	110735165	138515456	4	17608											
RFX5	5993	broad.mit.edu	37	chr1	151315095	151315095	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tcctttccccacttccacctGacttttttcgagggcgcccc	6	18	0	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:151315095G>C	uc001exv.1	-	11	1632	c.1418C>G	c.(1417-1419)TCA>TGA	p.S473*	RFX5_uc001exw.1_Nonsense_Mutation_p.S473*|RFX5_uc009wmr.1_Nonsense_Mutation_p.S473*|RFX5_uc010pcx.1_Nonsense_Mutation_p.S433*	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	473						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACTTCCACCTGACTTTTTTCG	0.547													C	151315095	C	C	151315095	4	2	247	1	0	0	0	0	0	1	0	0	13266	1294	45	5	436	5	RFX5	1	151315095	Nonsense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	40579930	151315095	97935526	5	17609											
IL20	50604	broad.mit.edu	37	chr1	207039922	207039922	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccctgaccattatactctcCggaagatcagcagcctcgcc	7	17	2	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:207039922C>T	uc001her.2	+	3	363	c.319C>T	c.(319-321)CGG>TGG	p.R107W	IL20_uc010pry.1_Missense_Mutation_p.R178W|IL20_uc009xby.2_Missense_Mutation_p.R107W	NM_018724	NP_061194	Q9NYY1	IL20_HUMAN	interleukin 20 precursor	107					positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding				0	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)		TTATACTCTCCGGAAGATCAG	0.512													T	207039922	T	T	207039922	3	4	247	1	0	0	0	0	1	0	0	0	7667	643	23	2	329	2	IL20	1	207039922	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	55724827	207039922	42210699	6	17610											
OBSCN	84033	broad.mit.edu	37	chr1	228557666	228557666	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacctgctcatccccatttgCcggcgagagtgaccgtgcca	11	15	1	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:228557666C>T	uc009xez.1	+	91	20035	c.19991C>T	c.(19990-19992)GCC>GTC	p.A6664V	OBSCN_uc001hsr.1_Missense_Mutation_p.A1293V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6664	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCCCCATTTGCCGGCGAGAGT	0.632													T	228557666	T	T	228557666	3	4	247	1	0	0	0	0	1	0	0	0	10812	739	26	3	21559	3	OBSCN	1	228557666	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	21517744	228557666	20692955	7	17611											
ZP4	57829	broad.mit.edu	37	chr1	238050155	238050155	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gttcattttcatatactgctCggtctccagtgatctacagg	8	10	4	1	rs148891266	byFrequency	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr1:238050155C>T	uc001hym.2	-	6	755	c.755G>A	c.(754-756)CGA>CAA	p.R252Q	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	252	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ATATACTGCTCGGTCTCCAGT	0.473													T	238050155	T	T	238050155	3	4	247	1	0	0	0	0	1	0	0	0	18215	884	31	2	895	2	ZP4	1	238050155	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	9492489	238050155	11200466	8	17612											
KCNH7	90134	broad.mit.edu	37	chr2	163253351	163253351	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacctctaacaagtcttctcGctgaatcttatgcaagtcac	5	12	5	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr2:163253351G>A	uc002uch.1	-	11	2724	c.2512C>T	c.(2512-2514)CGA>TGA	p.R838*		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	838	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	AAGTCTTCTCGCTGAATCTTA	0.383													A	163253351	A	A	163253351	4	1	247	1	0	0	0	0	0	1	0	0	8037	1095	38	1	1102	1	KCNH7	2	163253351	Nonsense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08		163253351	79946022	9	17613											
TTC21B	79809	broad.mit.edu	37	chr2	166799848	166799848	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aagccatgctttcaaaacgtGtccctgtaaaatgaataatt	6	8	1	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr2:166799848G>T	uc002udk.2	-	5	566	c.433C>A	c.(433-435)CAC>AAC	p.H145N	TTC21B_uc002udl.2_Missense_Mutation_p.H145N|uc002udm.1_Intron	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	145	TPR 2.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						TTCAAAACGTGTCCCTGTAAA	0.313													T	166799848	T	T	166799848	3	4	247	1	0	0	0	0	1	0	0	0	16685	1377	48	5	3617	5	TTC21B	2	166799848	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	3546497	166799848	76399525	10	17614											
SDPR	8436	broad.mit.edu	37	chr2	192700730	192700730	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctcctcggatgttagcgcGtagctaccctcatagcgtac	10	14	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr2:192700730G>A	uc002utb.2	-	2	1527	c.1197C>T	c.(1195-1197)TAC>TAT	p.Y399Y		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	399						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	ATGTTAGCGCGTAGCTACCCT	0.612													A	192700730	A	A	192700730	2	1	247	1	0	0	0	0	0	0	0	1	13970	1140	40	1		1	SDPR	2	192700730	Silent	SNP	G	TCGA-41-3393-01A-01D-1353-08	25900882	192700730	50498643	11	17615											
KIAA1486	57624	broad.mit.edu	37	chr2	226447389	226447389	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgcccccacccccgtctaCgctgtaccgaacccagtctc	7	21	2	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr2:226447389C>T	uc002voe.2	+	4	1431	c.1256C>T	c.(1255-1257)ACG>ATG	p.T419M	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.T189M	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	419	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		CCCCCGTCTACGCTGTACCGA	0.662													T	226447389	T	T	226447389	3	4	247	1	0	0	0	0	1	0	0	0	8237	536	19	1	1266	1	KIAA1486	2	226447389	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	33746659	226447389	16751984	12	17616											
DNAH12	201625	broad.mit.edu	37	chr3	57488121	57488121	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccttcagtgtatcaacagccCagtgtaacacgtgttcagga	9	11	3	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:57488121C>A	uc003dit.2	-	10	1353	c.1172G>T	c.(1171-1173)TGG>TTG	p.W391L	DNAH12_uc003diu.2_Missense_Mutation_p.W391L	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	dynein heavy chain domain 2 isoform 1	391	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2						ATCAACAGCCCAGTGTAACAC	0.393													A	57488121	A	A	57488121	3	1	247	1	0	0	0	0	1	0	0	0	4600	595	21	5	8349	5	DNAH12	3	57488121	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08		57488121	140534309	13	17617											
SLC9A10	285335	broad.mit.edu	37	chr3	111901019	111901019	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctttgtttttatctagccaCggaatatgatatagaacttc	6	7	2	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:111901019C>T	uc003dyu.2	-	21	2832	c.2610G>A	c.(2608-2610)CCG>CCA	p.P870P	SLC9A10_uc011bhu.1_Silent_p.P133P|SLC9A10_uc010hqc.2_Silent_p.P822P	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	870	cNMP.				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						TATCTAGCCACGGAATATGAT	0.219													T	111901019	T	T	111901019	2	4	247	1	0	0	0	0	0	0	0	1	14710	523	19	1		1	SLC9A10	3	111901019	Silent	SNP	C	TCGA-41-3393-01A-01D-1353-08	54412898	111901019	86121411	14	17618											
UBA5	79876	broad.mit.edu	37	chr3	132390695	132390695	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtttcagggcatatacagctTataattcctggagaatctgc	9	8	2	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:132390695T>C	uc003epa.3	+	7	896	c.654T>C	c.(652-654)CTT>CTC	p.L218L	NPHP3_uc003eoz.1_Intron|UBA5_uc010htr.2_Silent_p.L162L|UBA5_uc010htt.2_Silent_p.L218L|UBA5_uc003epb.3_Silent_p.L162L	NM_024818	NP_079094	Q9GZZ9	UBA5_HUMAN	ubiquitin-activating enzyme 5 isoform 1	218					protein ufmylation	aggresome|cytoplasm|cytoplasm|nucleus	ATP binding|cofactor binding|metal ion binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding|UFM1 activating enzyme activity			kidney(1)	1						ATATACAGCTTATAATTCCTG	0.368													C	132390695	C	C	132390695	2	2	247	1	0	0	0	0	0	0	0	1	16827	1741	61	4		4	UBA5	3	132390695	Silent	SNP	T	TCGA-41-3393-01A-01D-1353-08	20489676	132390695	65631735	15	17619											
PRR23B	389151	broad.mit.edu	37	chr3	138739151	138739151	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccacttccagcccggcagacGagtcgtgctgcgctcctgag	12	16	0	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:138739151G>A	uc003esy.1	-	1	618	c.353C>T	c.(352-354)TCG>TTG	p.S118L		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	118										breast(1)	1						CCCGGCAGACGAGTCGTGCTG	0.632													A	138739151	A	A	138739151	3	1	247	1	0	0	0	0	1	0	0	0	12595	1059	37	2	448	2	PRR23B	3	138739151	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	6348456	138739151	59283279	16	17620											
B3GALNT1	8706	broad.mit.edu	37	chr3	160803715	160803715	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atatgaatgttcacttttaaTaaattcaaacagatcccgac	4	8	2	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:160803715T>A	uc003fdv.2	-	5	1247	c.828A>T	c.(826-828)TTA>TTT	p.L276F	B3GALNT1_uc003fdw.2_Missense_Mutation_p.L276F|B3GALNT1_uc003fdx.2_Missense_Mutation_p.L276F|B3GALNT1_uc003fdy.2_Missense_Mutation_p.L276F|B3GALNT1_uc003fdz.2_Missense_Mutation_p.L276F|B3GALNT1_uc003fea.2_Missense_Mutation_p.L276F|B3GALNT1_uc011bpa.1_Intron	NM_033169	NP_149359	O75752	B3GL1_HUMAN	UDP-Gal:betaGlcNAc beta	276	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			TCACTTTTAATAAATTCAAAC	0.363													A	160803715	A	A	160803715	3	1	247	1	0	0	0	0	1	0	0	0	1245	1403	49	5	171	5	B3GALNT1	3	160803715	Missense_Mutation	SNP	T	TCGA-41-3393-01A-01D-1353-08	22064564	160803715	37218715	17	17621											
MUC4	4585	broad.mit.edu	37	chr3	195509188	195509188	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaggctggtgacaggaagaGgggtggcgtgacctgtggat	19	5	0	3			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:195509188G>A	uc011bto.1	-	3	9339	c.8879C>T	c.(8878-8880)CCT>CTT	p.P2960L	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACAGGAAGAGGGGTGGCGTG	0.592													A	195509188	A	A	195509188	3	1	247	1	0	0	0	0	1	0	0	0	9978	1000	35	3		3	MUC4	3	195509188	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	34705473	195509188	2513242	18	17622											
NCBP2	22916	broad.mit.edu	37	chr3	196664454	196664454	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cccagtctgtgcgaatgattCggtcatccagacgcgtccca	10	14	2	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr3:196664454C>T	uc003fxd.1	-	3	416	c.326G>A	c.(325-327)CGA>CAA	p.R109Q	NCBP2_uc003fxb.1_Missense_Mutation_p.R39Q|NCBP2_uc011btz.1_Missense_Mutation_p.R91Q|NCBP2_uc003fxc.1_RNA|NCBP2_uc003fxe.1_Missense_Mutation_p.R56Q|NCBP2_uc003fxf.2_3'UTR	NM_007362	NP_031388	P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	109	RRM.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)		GCGAATGATTCGGTCATCCAG	0.527													T	196664454	T	T	196664454	3	4	247	1	0	0	0	0	1	0	0	0	10212	884	31	2	152	2	NCBP2	3	196664454	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	1155266	196664454	1357976	19	17623											
CSN2	1447	broad.mit.edu	37	chr4	70822070	70822070	+	Nonstop_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attaactttgaaatcttcttAgaccttaaaaataaacagat	3	6	2	3			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:70822070A>G	uc003hes.3	-	6	692	c.679T>C	c.(679-681)TAA>CAA	p.*227Q	CSN2_uc003het.3_Nonstop_Mutation_p.*226Q	NM_001891	NP_001882	P05814	CASB_HUMAN	casein beta precursor	227					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0						AAATCTTCTTAGACCTTAAAA	0.269													G	70822070	G	G	70822070	4	3	247	1	0	0	0	0	0	0	0	0	3948	433	15	4	5	4	CSN2	4	70822070	Nonstop_Mutation	SNP	A	TCGA-41-3393-01A-01D-1353-08		70822070	120332206	20	17624											
ALB	213	broad.mit.edu	37	chr4	74279142	74279142	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccaacttacttataggcggaCcttgccaagtatatctgtga	8	10	1	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:74279142C>G	uc003hgs.3	+	8	922	c.849C>G	c.(847-849)GAC>GAG	p.D283E	ALB_uc003hgw.3_Missense_Mutation_p.D91E|ALB_uc011cbe.1_5'UTR|ALB_uc003hgt.3_Missense_Mutation_p.D283E|ALB_uc010iii.2_Missense_Mutation_p.D168E|ALB_uc003hgu.3_Missense_Mutation_p.D133E|ALB_uc003hgv.3_5'UTR|ALB_uc011cbf.1_Missense_Mutation_p.D173E|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'UTR	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	283	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TATAGGCGGACCTTGCCAAGT	0.393													G	74279142	G	G	74279142	3	3	247	1	0	0	0	0	1	0	0	0	486	506	18	5	879	5	ALB	4	74279142	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	3457072	74279142	116875134	21	17625											
AFM	173	broad.mit.edu	37	chr4	74354363	74354363	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagatatattgcgatactcAgtcaaaaattccccaagatt	5	10	2	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:74354363A>G	uc003hhb.2	+	7	761	c.730A>G	c.(730-732)AGT>GGT	p.S244G		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	244	Albumin 2.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGCGATACTCAGTCAAAAATT	0.343													G	74354363	G	G	74354363	3	3	247	1	0	0	0	0	1	0	0	0	361	188	7	4	756	4	AFM	4	74354363	Missense_Mutation	SNP	A	TCGA-41-3393-01A-01D-1353-08	75221	74354363	116799913	22	17626											
MMRN1	22915	broad.mit.edu	37	chr4	90874191	90874191	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatgcacccatggtggcattTtttgcatctcatacgtatgg	9	9	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:90874191T>G	uc003hst.2	+	8	3380	c.3309T>G	c.(3307-3309)TTT>TTG	p.F1103L	MMRN1_uc010iku.2_Missense_Mutation_p.F406L|MMRN1_uc011cds.1_Missense_Mutation_p.F845L	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1103	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TGGTGGCATTTTTTGCATCTC	0.338													G	90874191	G	G	90874191	3	3	247	1	0	0	0	0	1	0	0	0	9670	1838	64	5	3339	5	MMRN1	4	90874191	Missense_Mutation	SNP	T	TCGA-41-3393-01A-01D-1353-08	16519828	90874191	100280085	23	17627											
KLKB1	3818	broad.mit.edu	37	chr4	187157968	187157968	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	catttataaaggagttgataTgagaggagtcaattttaatg	10	2	1	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr4:187157968T>A	uc003iyy.2	+	5	433	c.362T>A	c.(361-363)ATG>AAG	p.M121K	KLKB1_uc011clc.1_5'UTR|KLKB1_uc011cld.1_Missense_Mutation_p.M83K	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	121	Apple 2.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GGAGTTGATATGAGAGGAGTC	0.378													A	187157968	A	A	187157968	3	1	247	1	0	0	0	0	1	0	0	0	8412	1464	51	5	376	5	KLKB1	4	187157968	Missense_Mutation	SNP	T	TCGA-41-3393-01A-01D-1353-08	96283777	187157968	3996308	24	17628											
C5orf32	84418	broad.mit.edu	37	chr5	139622928	139622928	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagaagagatgagctaggaCcatccacctgcctcacagcc	9	13	1	3			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr5:139622928C>T	uc003lfd.2	+	3	464	c.226C>T	c.(226-228)CCA>TCA	p.P76S	C5orf32_uc010jfi.2_RNA	NM_032412	NP_115788	Q9H1C7	CE032_HUMAN	hypothetical protein LOC84418	76											0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGCTAGGACCATCCACCTG	0.582													T	139622928	T	T	139622928	3	4	247	1	0	0	0	0	1	0	0	0	2291	507	18	3	232	3	C5orf32	5	139622928	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08		139622928	41292332	25	17629											
SH3TC2	79628	broad.mit.edu	37	chr5	148417964	148417964	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagcccaggtatgacaaagcCgatgatctcaatgctttctc	8	11	2	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr5:148417964C>T	uc003lpu.2	-	8	1047	c.895G>A	c.(895-897)GGC>AGC	p.G299S	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Missense_Mutation_p.G292S|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_Missense_Mutation_p.G184S	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	299	SH3.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAAAGCCGATGATCTCA	0.473													T	148417964	T	T	148417964	3	4	247	1	0	0	0	0	1	0	0	0	14262	652	23	2	3011	2	SH3TC2	5	148417964	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	8795036	148417964	32497296	26	17630											
OR2J3	442186	broad.mit.edu	37	chr6	29080039	29080039	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggtggtgatgtcctatgaCcgttatgcagctgtgtgtag	14	7	0	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr6:29080039C>T	uc011dll.1	+	1	372	c.372C>T	c.(370-372)GAC>GAT	p.D124D		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGTCCTATGACCGTTATGCAG	0.488													T	29080039	T	T	29080039	2	4	247	1	0	0	0	0	0	0	0	1	11004	506	18	3		3	OR2J3	6	29080039	Silent	SNP	C	TCGA-41-3393-01A-01D-1353-08		29080039	142035028	27	17631											
TNXB	7148	broad.mit.edu	37	chr6	32041532	32041532	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgtagactgtgacctctcGctggtctgccgccaccggca	12	14	2	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr6:32041532G>A	uc003nzl.2	-	12	4775	c.4573C>T	c.(4573-4575)CGA>TGA	p.R1525*		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1612	Fibronectin type-III 8.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GTGACCTCTCGCTGGTCTGCC	0.567													A	32041532	A	A	32041532	4	1	247	1	0	0	0	0	0	1	0	0	16343	1095	38	1	10272	1	TNXB	6	32041532	Nonsense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	2961493	32041532	139073535	28	17632											
C6orf89	221477	broad.mit.edu	37	chr6	36891125	36891125	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttgctatttcccctcaaggcTatgtcgacaccacccactgg	7	15	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr6:36891125T>A	uc003omx.2	+	9	1236	c.952T>A	c.(952-954)TAT>AAT	p.Y318N	C6orf89_uc003omv.2_Missense_Mutation_p.Y212N|C6orf89_uc003omw.2_Missense_Mutation_p.Y325N|C6orf89_uc011dtr.1_Missense_Mutation_p.Y212N|C6orf89_uc003omy.2_Missense_Mutation_p.Y152N	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	318						integral to membrane				ovary(1)	1						CCCTCAAGGCTATGTCGACAC	0.552													A	36891125	A	A	36891125	3	1	247	1	0	0	0	0	1	0	0	0	2373	1522	53	5	1003	5	C6orf89	6	36891125	Missense_Mutation	SNP	T	TCGA-41-3393-01A-01D-1353-08	4849593	36891125	134223942	29	17633											
AOAH	313	broad.mit.edu	37	chr7	36616236	36616236	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggtttcttttccataagCgaaggtaaatagatttttct	8	5	2	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:36616236C>T	uc003tfh.3	-	13	1366	c.965G>A	c.(964-966)CGC>CAC	p.R322H	AOAH_uc010kxf.2_Missense_Mutation_p.R322H|AOAH_uc011kba.1_Missense_Mutation_p.R290H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	322					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						TTTCCATAAGCGAAGGTAAAT	0.303													T	36616236	T	T	36616236	3	4	247	1	0	0	0	0	1	0	0	0	726	768	27	1	1139	1	AOAH	7	36616236	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08		36616236	122522427	30	17634											
HECW1	23072	broad.mit.edu	37	chr7	43484236	43484236	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ccaaggaggagcccttggagGaggaagcaacgacccagagc	15	11	0	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:43484236G>T	uc003tid.1	+	11	2070	c.1465G>T	c.(1465-1467)GAG>TAG	p.E489*	HECW1_uc011kbi.1_Nonsense_Mutation_p.E489*	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	489	Glu-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GCCCTTGGAGGAGGAAGCAAC	0.537													T	43484236	T	T	43484236	4	4	247	1	0	0	0	0	0	1	0	0	7042	1175	41	5	1499	5	HECW1	7	43484236	Nonsense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	6868000	43484236	115654427	31	17635											
DDC	1644	broad.mit.edu	37	chr7	50534977	50534977	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaaagcggggatcctggcGcaccagtgactcaaactcat	10	12	3	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:50534977G>A	uc003tpf.3	-	13	1263	c.1177C>T	c.(1177-1179)CGC>TGC	p.R393C	DDC_uc010kza.2_Missense_Mutation_p.R308C|DDC_uc003tpg.3_Missense_Mutation_p.R393C	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	393					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	GGATCCTGGCGCACCAGTGAC	0.433													A	50534977	A	A	50534977	3	1	247	1	0	0	0	0	1	0	0	0	4325	1087	38	1	273	1	DDC	7	50534977	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	7050741	50534977	108603686	32	17636											
DDC	1644	broad.mit.edu	37	chr7	50607722	50607722	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtaggggctgtgccagtgcGtcacctgcatgggaggacag	17	9	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:50607722G>A	uc003tpf.3	-	3	292	c.206C>T	c.(205-207)ACG>ATG	p.T69M	DDC_uc010kza.2_Missense_Mutation_p.T69M|DDC_uc003tpg.3_Missense_Mutation_p.T69M	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	69	1.|2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	GTGCCAGTGCGTCACCTGCAT	0.647													A	50607722	A	A	50607722	3	1	247	1	0	0	0	0	1	0	0	0	4325	1145	40	1	1284	1	DDC	7	50607722	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	72745	50607722	108530941	33	17637											
SEMA3D	223117	broad.mit.edu	37	chr7	84727157	84727157	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttaagtcaaccagactgagTagaaagatgtggtctttggc	11	6	2	4			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:84727157T>C	uc003uic.2	-	2	316	c.276A>G	c.(274-276)CTA>CTG	p.L92L	SEMA3D_uc010led.2_Silent_p.L92L|SEMA3D_uc010lee.1_Silent_p.L92L	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	92	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CCAGACTGAGTAGAAAGATGT	0.363													C	84727157	C	C	84727157	2	2	247	1	0	0	0	0	0	0	0	1	14027	1625	57	4		4	SEMA3D	7	84727157	Silent	SNP	T	TCGA-41-3393-01A-01D-1353-08	34119435	84727157	74411506	34	17638											
ADAM22	53616	broad.mit.edu	37	chr7	87774461	87774461	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcttgatcctcctgagtgtGgcaatggcttcattgaaact	9	9	2	3			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:87774461G>A	uc003ujn.2	+	16	1421	c.1342G>A	c.(1342-1344)GGC>AGC	p.G448S	ADAM22_uc003ujk.1_Missense_Mutation_p.G448S|ADAM22_uc003ujl.1_Missense_Mutation_p.G448S|ADAM22_uc003ujm.2_Missense_Mutation_p.G448S|ADAM22_uc003ujo.2_Missense_Mutation_p.G448S|ADAM22_uc003ujp.1_Missense_Mutation_p.G500S	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	448	Disintegrin.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TCCTGAGTGTGGCAATGGCTT	0.408													A	87774461	A	A	87774461	3	1	247	1	0	0	0	0	1	0	0	0	244	1348	47	3	1404	3	ADAM22	7	87774461	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	3047304	87774461	71364202	35	17639											
ZC3HAV1	56829	broad.mit.edu	37	chr7	138764823	138764823	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggtgagatcgtccacaggCgcgtcctccagggaagccct	14	14	0	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:138764823C>T	uc003vun.2	-	4	1252	c.864G>A	c.(862-864)GCG>GCA	p.A288A	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Silent_p.A288A	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	288	Nuclear export signal (By similarity).				response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						CGTCCACAGGCGCGTCCTCCA	0.587													T	138764823	T	T	138764823	2	4	247	1	0	0	0	0	0	0	0	1	17572	755	27	1		1	ZC3HAV1	7	138764823	Silent	SNP	C	TCGA-41-3393-01A-01D-1353-08	50990362	138764823	20373840	36	17640											
MKRN1	23608	broad.mit.edu	37	chr7	140154505	140154505	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctctctttcctcaatgagttCccagaagtggttccttcgtt	7	12	2	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr7:140154505C>A	uc003vvt.2	-	8	1486	c.1261G>T	c.(1261-1263)GAA>TAA	p.E421*	MKRN1_uc003vvs.2_Nonsense_Mutation_p.E357*|MKRN1_uc011krd.1_Nonsense_Mutation_p.E155*	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	421							ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					TCAATGAGTTCCCAGAAGTGG	0.468													A	140154505	A	A	140154505	4	1	247	1	0	0	0	0	0	1	0	0	9606	864	30	5	191	5	MKRN1	7	140154505	Nonsense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	1389682	140154505	18984158	37	17641											
PIWIL2	55124	broad.mit.edu	37	chr8	22165552	22165552	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccaccaatgaactgatgcGttgggggctccgtctgcaaa	12	11	1	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr8:22165552G>A	uc003xbn.2	+	14	1800	c.1652G>A	c.(1651-1653)CGT>CAT	p.R551H	PIWIL2_uc011kzf.1_Missense_Mutation_p.R551H|PIWIL2_uc010ltv.2_Missense_Mutation_p.R551H	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	551					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		GAACTGATGCGTTGGGGGCTC	0.453													A	22165552	A	A	22165552	3	1	247	1	0	0	0	0	1	0	0	0	11958	1145	40	1	1702	1	PIWIL2	8	22165552	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08		22165552	124198470	38	17642											
ADAM28	10863	broad.mit.edu	37	chr8	24181517	24181517	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatattgctcagttaatcacGtatgtacagattttctccca	6	9	3	1	rs138768775		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr8:24181517G>A	uc003xdy.2	+	9	973	c.890_splice	c.e9+1	p.T297_splice	ADAM28_uc003xdx.2_Splice_Site_p.T297_splice|ADAM28_uc011kzz.1_Splice_Site_p.T64_splice|ADAM28_uc011laa.1_Splice_Site|ADAM28_uc010lua.2_5'Flank	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1						proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AGTTAATCACGTATGTACAGA	0.423													A	24181517	A	A	24181517	5	1	247	1	0	0	0	0	0	0	1	0	246	1159	40	1	925	1	ADAM28	8	24181517	Splice_Site	SNP	G	TCGA-41-3393-01A-01D-1353-08	2015965	24181517	122182505	39	17643											
PTGR1	22949	broad.mit.edu	37	chr9	114332377	114332377	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ccggagctccttacctctaaGacccatttcagcaagtcctt	6	15	2	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr9:114332377G>A	uc004bfh.2	-	9	976	c.873C>T	c.(871-873)GTC>GTT	p.V291V	ZNF483_uc004bfg.2_Intron|PTGR1_uc011lwr.1_Silent_p.V291V|PTGR1_uc004bfi.3_Silent_p.V291V|PTGR1_uc004bfj.3_Silent_p.V168V|PTGR1_uc010mue.2_Silent_p.V291V	NM_012212	NP_036344	Q14914	PTGR1_HUMAN	prostaglandin reductase 1 isoform 1	291					leukotriene metabolic process	cytoplasm	15-oxoprostaglandin 13-oxidase activity|2-alkenal reductase activity|alcohol dehydrogenase (NAD) activity|zinc ion binding				0						TTACCTCTAAGACCCATTTCA	0.303													A	114332377	A	A	114332377	2	1	247	1	0	0	0	0	0	0	0	1	12753	929	33	3		3	PTGR1	9	114332377	Silent	SNP	G	TCGA-41-3393-01A-01D-1353-08		114332377	26881054	40	17644											
TPRN	286262	broad.mit.edu	37	chr9	140086667	140086667	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtggacacatgggctcgccCgggtgtcagactccccccag	13	15	1	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr9:140086667C>T	uc004clt.2	-	3	1934	c.1934G>A	c.(1933-1935)CGG>CAG	p.R645Q	TPRN_uc004clu.2_Intron	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					sensory perception of sound	stereocilium					0						TGGGCTCGCCCGGGTGTCAGA	0.662													T	140086667	T	T	140086667	3	4	247	1	0	0	0	0	1	0	0	0	16418	652	23	2	106	2	TPRN	9	140086667	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	25754290	140086667	1126764	41	17645											
CACNA1B	774	broad.mit.edu	37	chr9	141012527	141012527	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atccctgtggggcggtcaggAgcactggtgagcactcccgg	16	12	1	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr9:141012527A>T	uc004cog.2	+	42	6052	c.5907A>T	c.(5905-5907)GGA>GGT	p.G1969G	CACNA1B_uc004coi.2_Silent_p.G1181G	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1969	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GGCGGTCAGGAGCACTGGTGA	0.642													T	141012527	T	T	141012527	2	4	247	1	0	0	0	0	0	0	0	1	2539	291	11	5		5	CACNA1B	9	141012527	Silent	SNP	A	TCGA-41-3393-01A-01D-1353-08	925860	141012527	200904	42	17646											
TNKS2	80351	broad.mit.edu	37	chr10	93579732	93579732	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcagcaggatataacagaGtaaagattgtacagctgtta	11	5	0	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr10:93579732G>A	uc001khp.2	+	6	967	c.670G>A	c.(670-672)GTA>ATA	p.V224I		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	224	ANK 4.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				ATATAACAGAGTAAAGATTGT	0.328													A	93579732	A	A	93579732	3	1	247	1	0	0	0	0	1	0	0	0	16318	1029	36	3	692	3	TNKS2	10	93579732	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08		93579732	41955015	43	17647											
MKI67	4288	broad.mit.edu	37	chr10	129902650	129902650	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatgtccactttcaccaggGgtatcttgagcctttgcttg	9	11	3	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr10:129902650G>A	uc001lke.2	-	13	7649	c.7454C>T	c.(7453-7455)CCC>CTC	p.P2485L	MKI67_uc001lkf.2_Missense_Mutation_p.P2125L|MKI67_uc009yav.1_Missense_Mutation_p.P2060L|MKI67_uc009yaw.1_Missense_Mutation_p.P1635L	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2485	16 X 122 AA approximate repeats.|13.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTCACCAGGGGTATCTTGAG	0.473													A	129902650	A	A	129902650	3	1	247	1	0	0	0	0	1	0	0	0	9598	1232	43	3	2328	3	MKI67	10	129902650	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	36322918	129902650	5632097	44	17648											
MUC5B	727897	broad.mit.edu	37	chr11	1156635	1156635	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggggacttcaacgggatgCccgtggtcagcgagctcctc	15	12	2	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr11:1156635C>T	uc009ycr.1	+	7	778	c.652C>T	c.(652-654)CCC>TCC	p.P218S		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	214	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CAACGGGATGCCCGTGGTCAG	0.612													T	1156635	T	T	1156635	3	4	247	1	0	0	0	0	1	0	0	0	9979	754	26	3		3	MUC5B	11	1156635	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08		1156635	133849881	45	17649											
BIRC3	330	broad.mit.edu	37	chr11	102195409	102195409	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgctcgtgctggtttctatTacactggtgtgaatgacaag	11	7	1	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr11:102195409T>C	uc001pgx.2	+	3	391	c.169T>C	c.(169-171)TAC>CAC	p.Y57H		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	57	BIR 1.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TGGTTTCTATTACACTGGTGT	0.438			T	MALT1	MALT								C	102195409	C	C	102195409	3	2	247	1	0	0	0	0	1	0	0	0	1436	1754	61	4	171	4	BIRC3	11	102195409	Missense_Mutation	SNP	T	TCGA-41-3393-01A-01D-1353-08	101038774	102195409	32811107	46	17650											
ETS1	2113	broad.mit.edu	37	chr11	128426243	128426243	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agttgccatctcatcccaaaAggggtagcaaggtctttgct	10	10	2	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr11:128426243A>G	uc001qej.2	-	3	242	c.157T>C	c.(157-159)TTT>CTT	p.F53L		NM_001143820	NP_001137292	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		TCATCCCAAAAGGGGTAGCAA	0.448													G	128426243	G	G	128426243	3	3	247	1	0	0	0	0	1	0	0	0	5275	72	3	4	1418	4	ETS1	11	128426243	Missense_Mutation	SNP	A	TCGA-41-3393-01A-01D-1353-08	26230834	128426243	6580273	47	17651											
KCNA5	3741	broad.mit.edu	37	chr12	5153876	5153876	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggggccgcctgcggaggcCggtcaacgtctccctggacg	17	15	2	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:5153876C>T	uc001qni.2	+	1	792	c.563C>T	c.(562-564)CCG>CTG	p.P188L		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	188				RP -> G (in Ref. 1; AAA61276).		Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						CTGCGGAGGCCGGTCAACGTC	0.617													T	5153876	T	T	5153876	3	4	247	1	0	0	0	0	1	0	0	0	8006	652	23	2	565	2	KCNA5	12	5153876	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08		5153876	128698019	48	17652											
SMARCD1	6602	broad.mit.edu	37	chr12	50484023	50484023	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctatactttggttccctgcaGcctccccagtttaaattaga	6	12	0	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:50484023G>A	uc001rvx.3	+	8	1044	c.874_splice	c.e8-1	p.P292_splice	SMARCD1_uc001rvy.3_Splice_Site_p.P292_splice|SMARCD1_uc009zlp.2_Splice_Site_p.P251_splice	NM_003076	NP_003067	Q96GM5	SMRD1_HUMAN	SWI/SNF-related matrix-associated						chromatin-mediated maintenance of transcription|nervous system development|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	protein complex scaffold|transcription coactivator activity			ovary(1)	1						GTTCCCTGCAGCCTCCCCAGT	0.458													A	50484023	A	A	50484023	5	1	247	1	0	0	0	0	0	0	1	0	14777	985	34	3	903	3	SMARCD1	12	50484023	Splice_Site	SNP	G	TCGA-41-3393-01A-01D-1353-08	45330147	50484023	83367872	49	17653											
LACRT	90070	broad.mit.edu	37	chr12	55025622	55025622	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atacttttctccactatggaTtctaattttggagcagaaca	6	8	2	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:55025622T>C	uc001sgi.1	-	4	293	c.255A>G	c.(253-255)AAA>AAG	p.K85K		NM_033277	NP_150593	Q9GZZ8	LACRT_HUMAN	lacritin precursor	85					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			central_nervous_system(1)	1						CCACTATGGATTCTAATTTTG	0.468													C	55025622	C	C	55025622	2	2	247	1	0	0	0	0	0	0	0	1	8596	1507	52	4		4	LACRT	12	55025622	Silent	SNP	T	TCGA-41-3393-01A-01D-1353-08	4541599	55025622	78826273	50	17654											
MYF5	4617	broad.mit.edu	37	chr12	81111227	81111227	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatcctcaggaatgccatcCgctacatcgagagcctgcag	10	13	1	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:81111227C>T	uc001szg.2	+	1	520	c.385C>T	c.(385-387)CGC>TGC	p.R129C		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	129	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						GAATGCCATCCGCTACATCGA	0.587													T	81111227	T	T	81111227	3	4	247	1	0	0	0	0	1	0	0	0	10027	652	23	2	387	2	MYF5	12	81111227	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	26085605	81111227	52740668	51	17655											
TMEM132D	121256	broad.mit.edu	37	chr12	129558604	129558604	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttacccttttcctttttgagGtaggggatgttgggggctca	13	7	1	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr12:129558604G>A	uc009zyl.1	-	9	3444	c.3116C>T	c.(3115-3117)ACC>ATC	p.T1039I	TMEM132D_uc001uia.2_Missense_Mutation_p.T577I	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	1039	Cytoplasmic (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CCTTTTTGAGGTAGGGGATGT	0.488													A	129558604	A	A	129558604	3	1	247	1	0	0	0	0	1	0	0	0	16044	1261	44	3	187	3	TMEM132D	12	129558604	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	48447377	129558604	4293291	52	17656											
HECTD1	25831	broad.mit.edu	37	chr14	31675061	31675061	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcatgcatagctgttcaaGggctattagttgcatgtccc	10	10	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr14:31675061G>A	uc001wrc.1	-	2	571	c.82C>T	c.(82-84)CTT>TTT	p.L28F	HECTD1_uc001wre.2_RNA	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	28					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		AGCTGTTCAAGGGCTATTAGT	0.428													A	31675061	A	A	31675061	3	1	247	1	0	0	0	0	1	0	0	0	7039	1000	35	3	7918	3	HECTD1	14	31675061	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08		31675061	75674479	53	17657											
ARHGAP5	394	broad.mit.edu	37	chr14	32561946	32561946	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agatcagaaaagataaatacAtggctaatcttccatttaca	5	7	2	3			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr14:32561946A>T	uc001wrl.2	+	2	2310	c.2071A>T	c.(2071-2073)ATG>TTG	p.M691L	ARHGAP5_uc001wrm.2_Missense_Mutation_p.M691L|ARHGAP5_uc001wrn.2_Missense_Mutation_p.M691L|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	691					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AGATAAATACATGGCTAATCT	0.358													T	32561946	T	T	32561946	3	4	247	1	0	0	0	0	1	0	0	0	886	217	8	5	2073	5	ARHGAP5	14	32561946	Missense_Mutation	SNP	A	TCGA-41-3393-01A-01D-1353-08	886885	32561946	74787594	54	17658											
DICER1	23405	broad.mit.edu	37	chr14	95590756	95590756	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcatatggtttatatttgcGtaagatttcgagcagtttga	9	5	1	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr14:95590756G>A	uc001ydw.2	-	9	1335	c.1153C>T	c.(1153-1155)CGC>TGC	p.R385C	DICER1_uc001ydv.2_Missense_Mutation_p.R375C|DICER1_uc001ydx.2_Missense_Mutation_p.R385C	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	385	Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TTATATTTGCGTAAGATTTCG	0.378			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				A	95590756	A	A	95590756	3	1	247	1	0	0	0	0	1	0	0	0	4521	1145	40	1	4695	1	DICER1	14	95590756	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	63028810	95590756	11758784	55	17659											
GABRA5	2558	broad.mit.edu	37	chr15	27128491	27128491	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcctttccactaggagtacaCcatagacgtgtttttccgac	7	12	0	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr15:27128491C>A	uc001zbd.1	+	7	623	c.284C>A	c.(283-285)ACC>AAC	p.T95N	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	95	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TAGGAGTACACCATAGACGTG	0.592													A	27128491	A	A	27128491	3	1	247	1	0	0	0	0	1	0	0	0	6164	507	18	5	298	5	GABRA5	15	27128491	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08		27128491	75402901	56	17660											
ALPK3	57538	broad.mit.edu	37	chr15	85407896	85407896	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccttgtcacagacttggcaGgtacgagggtgtgagggtgc	16	8	1	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr15:85407896G>A	uc002ble.2	+	12	5496	c.5329G>A	c.(5329-5331)GGG>AGG	p.G1777R	ALPK3_uc010upc.1_Missense_Mutation_p.G78R	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1777	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGACTTGGCAGGTACGAGGGT	0.507													A	85407896	A	A	85407896	3	1	247	1	0	0	0	0	1	0	0	0	546	1014	35	3	5375	3	ALPK3	15	85407896	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	58279405	85407896	17123496	57	17661											
PLEKHG4	25894	broad.mit.edu	37	chr16	67318812	67318812	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagtgccgctgggcctgggCgcggtgccaggacacctggc	19	13	0	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr16:67318812C>T	uc002eso.3	+	12	4424	c.1889C>T	c.(1888-1890)GCG>GTG	p.A630V	PLEKHG4_uc002esp.3_Missense_Mutation_p.A437V|PLEKHG4_uc002esq.3_Missense_Mutation_p.A630V|PLEKHG4_uc010cef.2_Missense_Mutation_p.A630V|PLEKHG4_uc002ess.3_Missense_Mutation_p.A630V|PLEKHG4_uc010ceg.2_Missense_Mutation_p.A549V	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	630					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		TGGGCCTGGGCGCGGTGCCAG	0.662													T	67318812	T	T	67318812	3	4	247	1	0	0	0	0	1	0	0	0	12071	768	27	1	1935	1	PLEKHG4	16	67318812	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08		67318812	23035941	58	17662											
CCDC42	146849	broad.mit.edu	37	chr17	8638565	8638565	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttctggatgtgcgcccagCgagattcctggagagtggat	15	8	1	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr17:8638565C>T	uc002gln.2	-	6	949	c.722G>A	c.(721-723)CGC>CAC	p.R241H	CCDC42_uc002glo.2_Missense_Mutation_p.R167H	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	241										ovary(1)	1						GTGCGCCCAGCGAGATTCCTG	0.473													T	8638565	T	T	8638565	3	4	247	1	0	0	0	0	1	0	0	0	2814	768	27	1	236	1	CCDC42	17	8638565	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08		8638565	72556645	59	17663											
CDC27	996	broad.mit.edu	37	chr17	45247352	45247352	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actcagtaacaatatcatcaTggcttttctgcttattaaac	4	9	4	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr17:45247352T>C	uc002ild.3	-	4	435	c.308A>G	c.(307-309)CAT>CGT	p.H103R	CDC27_uc002ile.3_Missense_Mutation_p.H103R|CDC27_uc002ilf.3_Missense_Mutation_p.H103R|CDC27_uc010wkp.1_Missense_Mutation_p.H42R|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	103	TPR 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						AATATCATCATGGCTTTTCTG	0.308													C	45247352	C	C	45247352	3	2	247	1	0	0	0	0	1	0	0	0	3066	1464	51	4	2248	4	CDC27	17	45247352	Missense_Mutation	SNP	T	TCGA-41-3393-01A-01D-1353-08	36608787	45247352	35947858	60	17664											
ESCO1	114799	broad.mit.edu	37	chr18	19154087	19154087	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctcagaagttacaggcaCaggtttcgtttcgtctcttc	8	12	2	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr18:19154087C>T	uc002kth.1	-	4	1652	c.718G>A	c.(718-720)GTG>ATG	p.V240M	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	240					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						GTTACAGGCACAGGTTTCGTT	0.418													T	19154087	T	T	19154087	3	4	247	1	0	0	0	0	1	0	0	0	5248	478	17	3	1840	3	ESCO1	18	19154087	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08		19154087	58923161	61	17665											
NETO1	81832	broad.mit.edu	37	chr18	70450913	70450913	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaagtgcagagaatcttacGttcttgaaaggatgtgaaga	11	5	3	4			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr18:70450913G>A	uc002lkw.2	-	7	1152	c.868C>T	c.(868-870)CCT>TCT	p.P290S	NETO1_uc002lkx.1_Missense_Mutation_p.P289S|NETO1_uc002lky.1_Missense_Mutation_p.P290S	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	290	Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AGAATCTTACGTTCTTGAAAG	0.458													A	70450913	A	A	70450913	3	1	247	1	0	0	0	0	1	0	0	0	10339	1159	40	1	749	1	NETO1	18	70450913	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	51296826	70450913	7626335	62	17666											
MUC16	94025	broad.mit.edu	37	chr19	9088222	9088222	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacttggtgtcaaggaagtcGtggaaggtaagttgggcatg	16	4	1	0	rs145987902	by1000genomes	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:9088222G>A	uc002mkp.2	-	1	3797	c.3593C>T	c.(3592-3594)ACG>ATG	p.T1198M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1198	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAAGGAAGTCGTGGAAGGTAA	0.473													A	9088222	A	A	9088222	3	1	247	1	0	0	0	0	1	0	0	0	9973	1145	40	1	40266	1	MUC16	19	9088222	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08		9088222	50040761	63	17667											
CPAMD8	27151	broad.mit.edu	37	chr19	17039895	17039895	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttctgatgcccccccaggaCgatctcgatcatgcctgctg	10	15	3	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:17039895C>T	uc002nfb.2	-	24	3174	c.3142G>A	c.(3142-3144)GTC>ATC	p.V1048I		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1001						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity	p.V1048I(1)		ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CCCCCCAGGACGATCTCGATC	0.607													T	17039895	T	T	17039895	3	4	247	1	0	0	0	0	1	0	0	0	3795	536	19	1	2732	1	CPAMD8	19	17039895	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	7951673	17039895	42089088	64	17668											
ZNF181	339318	broad.mit.edu	37	chr19	35232834	35232839	+	In_Frame_Del	DEL	ATATAA	-	-													attcacactggagaaaagccAtataaatgtaatgagtgtgg							TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:35232834_35232839delATATAA	uc002nvu.3	+	4	2011_2016	c.1548_1553delATATAA	c.(1546-1554)CCATATAAA>CCA	p.YK517del	ZNF181_uc010xsa.1_In_Frame_Del_p.YK516del|ZNF181_uc010xsb.1_In_Frame_Del_p.YK516del|ZNF181_uc010xsc.1_In_Frame_Del_p.YK452del	NM_001029997	NP_001025168	Q2M3W8	ZN181_HUMAN	zinc finger protein 181 isoform 1	517_518	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GAGAAAAGCCATATAAATGTAATGAG	0.388													-	35232839	-	-	35232834	7	5	247	1	0	1	0	1	0	0	0	0	17746	204	8	0	1562	0	ZNF181	19	35232834	In_Frame_Del	DEL	ATATAA	TCGA-41-3393-01A-01D-1353-08	18192939	35232834	23896149	65	17669											
UPK1A	11045	broad.mit.edu	37	chr19	36159540	36159540	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccgcactctgccgccgccGgtccatggtcctcacggtga	12	17	2	1	rs111275297		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:36159540G>A	uc002oaw.2	+	2	269	c.269G>A	c.(268-270)CGG>CAG	p.R90Q	UPK1A_uc010eeh.2_Missense_Mutation_p.R90Q|uc002oax.1_Missense_Mutation_p.R3W	NM_007000	NP_008931	O00322	UPK1A_HUMAN	uroplakin 1A	90	Cytoplasmic (Potential).				epithelial cell differentiation|protein oligomerization	endoplasmic reticulum|integral to membrane	monosaccharide binding|protein homodimerization activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGCCGCCGCCGGTCCATGGTC	0.592													A	36159540	A	A	36159540	3	1	247	1	0	0	0	0	1	0	0	0	17004	1116	39	2	275	2	UPK1A	19	36159540	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	926706	36159540	22969443	66	17670											
GPR77	27202	broad.mit.edu	37	chr19	47844750	47844750	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgggcagcccgacgctgcCggccgctgggcacagccatt	15	16	0	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:47844750C>T	uc010ela.1	+	2	912	c.694C>T	c.(694-696)CGG>TGG	p.R232W	GPR77_uc002pgk.1_Missense_Mutation_p.R232W	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	232	Cytoplasmic (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		CCGACGCTGCCGGCCGCTGGG	0.672													T	47844750	T	T	47844750	3	4	247	1	0	0	0	0	1	0	0	0	6709	643	23	2	696	2	GPR77	19	47844750	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	11685210	47844750	11284233	67	17671											
ELSPBP1	64100	broad.mit.edu	37	chr19	48519291	48519291	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagtggaaattctgtgaaaCgaatggtgagcccctgtagc	13	8	1	2	rs145971035		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:48519291C>T	uc002pht.2	+	4	505	c.350C>T	c.(349-351)ACG>ATG	p.T117M		NM_022142	NP_071425	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1 precursor	117	Fibronectin type-II 2.				single fertilization	extracellular region					0		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		TTCTGTGAAACGAATGGTGAG	0.552													T	48519291	T	T	48519291	3	4	247	1	0	0	0	0	1	0	0	0	5083	536	19	1	360	1	ELSPBP1	19	48519291	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	674541	48519291	10609692	68	17672											
DKKL1	27120	broad.mit.edu	37	chr19	49867863	49867863	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccacctgcccccgcaaggcGgcatctgctggtcctgctgc	11	19	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:49867863G>A	uc002pnk.2	+	2	249	c.35G>A	c.(34-36)CGG>CAG	p.R12Q	TEAD2_uc002pni.2_5'Flank|TEAD2_uc002pnj.2_5'Flank|TEAD2_uc010yao.1_5'Flank|TEAD2_uc010emw.2_5'Flank	NM_014419	NP_055234	Q9UK85	DKKL1_HUMAN	dickkopf-like 1 precursor	12					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity				0		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		CCCGCAAGGCGGCATCTGCTG	0.672													A	49867863	A	A	49867863	3	1	247	1	0	0	0	0	1	0	0	0	4548	1116	39	2	41	2	DKKL1	19	49867863	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	1348572	49867863	9261120	69	17673											
C19orf75	284369	broad.mit.edu	37	chr19	51768774	51768774	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atggcagcctccaagtgactTccaccatgcttggcccctgg	10	15	0	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr19:51768774T>A	uc002pwb.1	+	3	556	c.175T>A	c.(175-177)TCC>ACC	p.S59T	C19orf75_uc010eov.1_Intron|C19orf75_uc010ycw.1_Intron	NM_173635	NP_775906	Q8N7X8	CS075_HUMAN	hypothetical protein LOC284369	59						integral to membrane				ovary(1)|pancreas(1)	2						CCAAGTGACTTCCACCATGCT	0.567													A	51768774	A	A	51768774	3	1	247	1	0	0	0	0	1	0	0	0	1949	1783	62	5	181	5	C19orf75	19	51768774	Missense_Mutation	SNP	T	TCGA-41-3393-01A-01D-1353-08	1900911	51768774	7360209	70	17674											
SIGLEC1	6614	broad.mit.edu	37	chr20	3674185	3674185	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gaggtggcatccctgactgtGacgttgggcagggggatgga	19	7	0	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr20:3674185G>A	uc002wja.2	-	13	3417	c.3417C>T	c.(3415-3417)GTC>GTT	p.V1139V	SIGLEC1_uc002wjb.1_5'Flank|SIGLEC1_uc002wiz.3_Silent_p.V1139V	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1139	Ig-like C2-type 11.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CCCTGACTGTGACGTTGGGCA	0.657													A	3674185	A	A	3674185	2	1	247	1	0	0	0	0	0	0	0	1	14305	1277	45	3		3	SIGLEC1	20	3674185	Silent	SNP	G	TCGA-41-3393-01A-01D-1353-08		3674185	59351335	71	17675											
SRC	6714	broad.mit.edu	37	chr20	36026230	36026230	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggctggaggtcaagctgggcCagggctgctttggcgaggtg	20	8	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr20:36026230C>G	uc002xgx.2	+	9	1281	c.832C>G	c.(832-834)CAG>GAG	p.Q278E	SRC_uc002xgy.2_Missense_Mutation_p.Q278E	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	278	Protein kinase.|ATP.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	CAAGCTGGGCCAGGGCTGCTT	0.697													G	36026230	G	G	36026230	3	3	247	1	0	0	0	0	1	0	0	0	15133	595	21	5	854	5	SRC	20	36026230	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	32352045	36026230	26999290	72	17676											
PTPRT	11122	broad.mit.edu	37	chr20	40713368	40713368	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctcccgtcatactgctcctGccacttctccagtcgtcgga	7	18	2	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr20:40713368G>T	uc002xkg.2	-	29	4274	c.4090C>A	c.(4090-4092)CAG>AAG	p.Q1364K	PTPRT_uc010ggj.2_Missense_Mutation_p.Q1383K|PTPRT_uc010ggi.2_Missense_Mutation_p.Q567K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1364	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TACTGCTCCTGCCACTTCTCC	0.597													T	40713368	T	T	40713368	3	4	247	1	0	0	0	0	1	0	0	0	12812	1328	46	5	247	5	PTPRT	20	40713368	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	4687138	40713368	22312152	73	17677											
DIDO1	11083	broad.mit.edu	37	chr20	61511189	61511189	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggcccggcctcctcccagCggtccttccggtgctgcggg	15	18	0	0	rs143474883		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr20:61511189C>T	uc002ydr.1	-	16	6383	c.6119G>A	c.(6118-6120)CGC>CAC	p.R2040H	DIDO1_uc002yds.1_Missense_Mutation_p.R2040H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	2040					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTCCTCCCAGCGGTCCTTCCG	0.741													T	61511189	T	T	61511189	3	4	247	1	0	0	0	0	1	0	0	0	4522	768	27	1	607	1	DIDO1	20	61511189	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	20797821	61511189	1514331	74	17678											
PRAME	23532	broad.mit.edu	37	chr22	22891015	22891015	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gatgcatcacatccccttccGaaagccggcagttagttatt	8	12	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr22:22891015G>A	uc002zwf.2	-	5	1160	c.1004C>T	c.(1003-1005)TCG>TTG	p.S335L	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Missense_Mutation_p.S319L|PRAME_uc010gtr.2_Missense_Mutation_p.S335L|PRAME_uc002zwg.2_Missense_Mutation_p.S335L|PRAME_uc002zwh.2_Missense_Mutation_p.S335L|PRAME_uc002zwi.2_Missense_Mutation_p.S335L|PRAME_uc002zwj.2_Missense_Mutation_p.S335L|PRAME_uc002zwk.2_Missense_Mutation_p.S335L	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	335	LRR 1.				apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		ATCCCCTTCCGAAAGCCGGCA	0.542													A	22891015	A	A	22891015	3	1	247	1	0	0	0	0	1	0	0	0	12424	1059	37	2	529	2	PRAME	22	22891015	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08		22891015	28413551	75	17679											
ELFN2	114794	broad.mit.edu	37	chr22	37769438	37769438	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcctcgtagtacagggcggGaaagctgtgccggtgctcgc	15	12	0	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr22:37769438G>A	uc003asq.3	-	3	2923	c.2137C>T	c.(2137-2139)CCC>TCC	p.P713S		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	713	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					TACAGGGCGGGAAAGCTGTGC	0.552													A	37769438	A	A	37769438	3	1	247	1	0	0	0	0	1	0	0	0	5058	1174	41	3	329	3	ELFN2	22	37769438	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	14878423	37769438	13535128	76	17680											
ENTHD1	150350	broad.mit.edu	37	chr22	40283672	40283672	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctagagggaccccaagggtcGttagaagttgcttccctgac	12	11	0	3	rs146928757		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr22:40283672G>A	uc003ayg.2	-	2	332	c.81C>T	c.(79-81)AAC>AAT	p.N27N		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	27	ENTH.							p.N27N(1)		ovary(2)|skin(1)	3	Melanoma(58;0.0749)					CCCAAGGGTCGTTAGAAGTTG	0.398													A	40283672	A	A	40283672	2	1	247	1	0	0	0	0	0	0	0	1	5137	1136	40	1		1	ENTHD1	22	40283672	Silent	SNP	G	TCGA-41-3393-01A-01D-1353-08	2514234	40283672	11020894	77	17681											
ARSA	410	broad.mit.edu	37	chr22	51063597	51063597	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatggggatctgggcaatgGcagcaagctgggcggggggt	21	7	1	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chr22:51063597G>A	uc003bnb.3	-	9	1753	c.1500C>T	c.(1498-1500)TGC>TGT	p.C500C	ARSA_uc003bna.3_Silent_p.C416C|ARSA_uc003bnc.3_Silent_p.C500C|ARSA_uc003bnd.3_Silent_p.C500C|ARSA_uc003bmz.3_Silent_p.C500C	NM_001085426	NP_001078895	P15289	ARSA_HUMAN	arylsulfatase A isoform a precursor	500						lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			pancreas(1)|skin(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	CTGGGCAATGGCAGCAAGCTG	0.701													A	51063597	A	A	51063597	2	1	247	1	0	0	0	0	0	0	0	1	987	1195	42	3		3	ARSA	22	51063597	Silent	SNP	G	TCGA-41-3393-01A-01D-1353-08	10779925	51063597	240969	78	17682											
IL3RA	3563	broad.mit.edu	37	chrX	1471117	1471117	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtacgacctgtacttgaaCgttgccaagtaggtgtgccc	11	11	0	1	rs142385163	byFrequency	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:1471117C>T	uc004cps.2	+	5	772	c.423C>T	c.(421-423)AAC>AAT	p.N141N	IL3RA_uc011mhd.1_Silent_p.N63N	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	141	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TGTACTTGAACGTTGCCAAGT	0.647													T	1471117	T	T	1471117	2	4	247	1	0	0	0	0	0	0	0	1	7695	535	19	1		1	IL3RA	23	1471117	Silent	SNP	C	TCGA-41-3393-01A-01D-1353-08		1471117	153799443	79	17683											
ARSE	415	broad.mit.edu	37	chrX	2867414	2867414	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaagcacatgggctgctccGtgatggtgtggtttctcatc	14	9	1	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:2867414G>A	uc004crc.3	-	6	1035	c.785C>T	c.(784-786)ACG>ATG	p.T262M	ARSE_uc011mhi.1_Missense_Mutation_p.T208M|ARSE_uc011mhh.1_Missense_Mutation_p.T287M	NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	262					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGGCTGCTCCGTGATGGTGTG	0.532													A	2867414	A	A	2867414	3	1	247	1	0	0	0	0	1	0	0	0	990	1145	40	1	1008	1	ARSE	23	2867414	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	1396297	2867414	152403146	80	17684											
GPR143	4935	broad.mit.edu	37	chrX	9693807	9693807	+	Silent	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cataggtctccatgggttggGagagcagggtcaccctcatt	13	10	3	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:9693807G>C	uc004cst.1	-	9	1254	c.1254C>G	c.(1252-1254)CTC>CTG	p.L418L		NM_000273	NP_000264	P51810	GP143_HUMAN	G protein-coupled receptor 143	398	Cytoplasmic (Potential).				calcium-mediated signaling using intracellular calcium source|eye pigment biosynthetic process|melanosome organization|melanosome transport|phosphatidylinositol-mediated signaling|regulation of calcium-mediated signaling|visual perception	apical plasma membrane|Golgi apparatus|integral to membrane|lysosomal membrane|melanosome membrane|membrane fraction	dopamine binding|L-DOPA receptor activity|protein binding|tyrosine binding			ovary(1)	1		Hepatocellular(5;0.000888)				CATGGGTTGGGAGAGCAGGGT	0.473													C	9693807	C	C	9693807	2	2	247	1	0	0	0	0	0	0	0	1	6651	1161	41	5		5	GPR143	23	9693807	Silent	SNP	G	TCGA-41-3393-01A-01D-1353-08	6826393	9693807	145576753	81	17685											
FRMPD4	9758	broad.mit.edu	37	chrX	12735884	12735884	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taggccagcaaccgacctccCgcccaaagttgtgccttcca	8	17	0	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:12735884C>T	uc004cuz.1	+	16	3445	c.2939C>T	c.(2938-2940)CCG>CTG	p.P980L	FRMPD4_uc011mij.1_Missense_Mutation_p.P972L	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	980					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						ACCGACCTCCCGCCCAAAGTT	0.572													T	12735884	T	T	12735884	3	4	247	1	0	0	0	0	1	0	0	0	6059	652	23	2	3001	2	FRMPD4	23	12735884	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	3042077	12735884	142534676	82	17686											
FTSJ1	24140	broad.mit.edu	37	chrX	48337447	48337447	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgtccactgccaaggagatcAtccagcactttaagggctgc	10	12	1	1	rs75296308	byFrequency	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:48337447A>T	uc004djo.1	+	5	627	c.304A>T	c.(304-306)ATC>TTC	p.I102F	FTSJ1_uc004djl.2_Missense_Mutation_p.I102F|FTSJ1_uc004djm.2_Missense_Mutation_p.I102F|FTSJ1_uc004djn.1_Missense_Mutation_p.I102F|FTSJ1_uc004djp.1_Missense_Mutation_p.I102F|FTSJ1_uc011mlw.1_5'UTR	NM_012280	NP_036412	Q9UET6	RRMJ1_HUMAN	FtsJ homolog 1 isoform a	102					RNA methylation|rRNA processing		methyltransferase activity|nucleic acid binding				0						CAAGGAGATCATCCAGCACTT	0.632													T	48337447	T	T	48337447	3	4	247	1	0	0	0	0	1	0	0	0	6087	217	8	5	318	5	FTSJ1	23	48337447	Missense_Mutation	SNP	A	TCGA-41-3393-01A-01D-1353-08	35601563	48337447	106933113	83	17687											
PORCN	64840	broad.mit.edu	37	chrX	48374470	48374470	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctccggaagcgcctggctcGgatcctcagtgcctgtgtct	12	15	2	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:48374470G>A	uc010nie.1	+	13	1267	c.1109G>A	c.(1108-1110)CGG>CAG	p.R370Q	PORCN_uc004djr.1_Missense_Mutation_p.R365Q|PORCN_uc004djs.1_Missense_Mutation_p.R359Q|PORCN_uc004djt.1_Missense_Mutation_p.R288Q|PORCN_uc011mlx.1_Missense_Mutation_p.R288Q|PORCN_uc004dju.1_Missense_Mutation_p.R228Q|PORCN_uc004djv.1_Missense_Mutation_p.R370Q|PORCN_uc004djw.1_Missense_Mutation_p.R364Q	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	370	Extracellular (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						CGCCTGGCTCGGATCCTCAGT	0.627													A	48374470	A	A	48374470	3	1	247	1	0	0	0	0	1	0	0	0	12258	1116	39	2	1155	2	PORCN	23	48374470	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	37023	48374470	106896090	84	17688											
TSR2	90121	broad.mit.edu	37	chrX	54467162	54467162	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcgggggtgtgcacagccagGagaaggccaagtggctgggg	20	8	0	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:54467162G>A	uc004dte.2	+	2	123	c.121G>A	c.(121-123)GAG>AAG	p.E41K	TSR2_uc004dtf.2_Intron	NM_058163	NP_477511	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog	41					rRNA processing		protein binding				0						GCACAGCCAGGAGAAGGCCAA	0.607													A	54467162	A	A	54467162	3	1	247	1	0	0	0	0	1	0	0	0	16662	1175	41	3	127	3	TSR2	23	54467162	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	6092692	54467162	100803398	85	17689											
ZC3H12B	340554	broad.mit.edu	37	chrX	64721735	64721735	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgggccaaccaaccccagcGttcggtggctgatgagctcc	13	15	0	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:64721735G>A	uc010nko.2	+	5	1133	c.1124G>A	c.(1123-1125)CGT>CAT	p.R375H		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	375							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						CAACCCCAGCGTTCGGTGGCT	0.532													A	64721735	A	A	64721735	3	1	247	1	0	0	0	0	1	0	0	0	17559	1145	40	1	1175	1	ZC3H12B	23	64721735	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	10254573	64721735	90548825	86	17690											
SLC7A3	84889	broad.mit.edu	37	chrX	70147393	70147393	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcgtgtgccggtgtggatcCgagcaagtacacggaacagg	16	9	0	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:70147393C>T	uc004dyn.2	-	7	1282	c.1124G>A	c.(1123-1125)CGG>CAG	p.R375Q	SLC7A3_uc004dyo.2_Missense_Mutation_p.R375Q	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	375	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GGTGTGGATCCGAGCAAGTAC	0.577													T	70147393	T	T	70147393	3	4	247	1	0	0	0	0	1	0	0	0	14698	652	23	2	759	2	SLC7A3	23	70147393	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	5425658	70147393	85123167	87	17691											
RAB40A	142684	broad.mit.edu	37	chrX	102755508	102755508	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagcttcacccgctggccGtccagcaggatggtggtcgt	13	13	2	0			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:102755508G>A	uc004ekk.2	-	3	519	c.177C>T	c.(175-177)GAC>GAT	p.D59D		NM_080879	NP_543155	Q8WXH6	RB40A_HUMAN	RAB40A, member RAS oncogene family	59					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0						CCCGCTGGCCGTCCAGCAGGA	0.587													A	102755508	A	A	102755508	2	1	247	1	0	0	0	0	0	0	0	1	12939	1136	40	1		1	RAB40A	23	102755508	Silent	SNP	G	TCGA-41-3393-01A-01D-1353-08	32608115	102755508	52515052	88	17692											
NRK	203447	broad.mit.edu	37	chrX	105179166	105179166	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttacatctttgcagtataCgctggattcgtagaagtacc	8	10	1	1	rs56273831		TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:105179166C>T	uc004emd.2	+	21	3807	c.3504C>T	c.(3502-3504)TAC>TAT	p.Y1168Y	NRK_uc010npc.1_Silent_p.Y836Y	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1168							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TTGCAGTATACGCTGGATTCG	0.383										HNSCC(51;0.14)			T	105179166	T	T	105179166	2	4	247	1	0	0	0	0	0	0	0	1	10655	547	19	1		1	NRK	23	105179166	Silent	SNP	C	TCGA-41-3393-01A-01D-1353-08	2423658	105179166	50091394	89	17693											
RNF128	79589	broad.mit.edu	37	chrX	105970562	105970562	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggcttatgagagaggggCgtctggagccgtcatcttta	14	8	4	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:105970562C>T	uc004eml.2	+	1	669	c.419C>T	c.(418-420)GCG>GTG	p.A140V	RNF128_uc004emk.2_Intron	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	140	PA.					endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GAGAGAGGGGCGTCTGGAGCC	0.597													T	105970562	T	T	105970562	3	4	247	1	0	0	0	0	1	0	0	0	13436	768	27	1	831	1	RNF128	23	105970562	Missense_Mutation	SNP	C	TCGA-41-3393-01A-01D-1353-08	791396	105970562	49299998	90	17694											
DOCK11	139818	broad.mit.edu	37	chrX	117748686	117748686	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actaatggatagaggatttaTtttcaatttaataaatgact	6	3	1	2			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:117748686T>C	uc004eqp.2	+	29	3191	c.3128T>C	c.(3127-3129)ATT>ACT	p.I1043T	DOCK11_uc004eqq.2_Missense_Mutation_p.I809T	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1043					blood coagulation	cytosol	GTP binding			ovary(3)	3						AGAGGATTTATTTTCAATTTA	0.299													C	117748686	C	C	117748686	3	2	247	1	0	0	0	0	1	0	0	0	4686	1493	52	4	3242	4	DOCK11	23	117748686	Missense_Mutation	SNP	T	TCGA-41-3393-01A-01D-1353-08	11778124	117748686	37521874	91	17695											
USP26	83844	broad.mit.edu	37	chrX	132161937	132161937	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcacaggtggctgaacctcGttttgatgaactctgtccaa	9	11	2	3	rs142413133	byFrequency	TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:132161937G>A	uc010nrm.1	-	6	782	c.312C>T	c.(310-312)AAC>AAT	p.N104N	USP26_uc011mvf.1_Silent_p.N104N	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	104					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					GCTGAACCTCGTTTTGATGAA	0.383													A	132161937	A	A	132161937	2	1	247	1	0	0	0	0	0	0	0	1	17054	1136	40	1		1	USP26	23	132161937	Silent	SNP	G	TCGA-41-3393-01A-01D-1353-08	14413251	132161937	23108623	92	17696											
ZNF75D	7626	broad.mit.edu	37	chrX	134426220	134426220	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcctcacctctttcatatacAggctgggtttctttgtgagt	8	10	4	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:134426220A>G	uc004eyp.2	-	4	3246	c.591T>C	c.(589-591)CCT>CCC	p.P197P	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'UTR|ZNF75D_uc004eyo.2_Intron	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	197					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTTCATATACAGGCTGGGTTT	0.463													G	134426220	G	G	134426220	2	3	247	1	0	0	0	0	0	0	0	1	18131	175	7	4		4	ZNF75D	23	134426220	Silent	SNP	A	TCGA-41-3393-01A-01D-1353-08	2264283	134426220	20844340	93	17697											
PASD1	139135	broad.mit.edu	37	chrX	150840069	150840069	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccaaacacattacgccacGttgtcattcctgatctccaa	5	14	2	1			TCGA-41-3393-01A-01D-1353-08	TCGA-41-3393-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	34d7ef73-5344-4743-a9fa-0162c3cfde47	3f0e2a97-0099-4d80-876c-d1681db4f649	g.chrX:150840069G>A	uc004fev.3	+	13	1587	c.1255G>A	c.(1255-1257)GTT>ATT	p.V419I		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	419						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATTACGCCACGTTGTCATTCC	0.498													A	150840069	A	A	150840069	3	1	247	1	0	0	0	0	1	0	0	0	11471	1145	40	1	1301	1	PASD1	23	150840069	Missense_Mutation	SNP	G	TCGA-41-3393-01A-01D-1353-08	16413849	150840069	4430491	94	17698											
TNFRSF4	7293	broad.mit.edu	37	chr1	1149428	1149428	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccgacacagtggagccccGtcacggtgctcagccccagg	12	18	2	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:1149428G>A	uc001ade.2	-	1	85	c.80C>T	c.(79-81)ACG>ATG	p.T27M	TNFRSF4_uc001adf.2_Translation_Start_Site	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	27					immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GTGGAGCCCCGTCACGGTGCT	0.726													A	1149428	A	A	1149428	3	1	248	1	0	0	0	0	1	0	0	0	16294	1145	40	1	781	1	TNFRSF4	1	1149428	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08		1149428	248101193	1	17699											
KAZ	23254	broad.mit.edu	37	chr1	15370623	15370623	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctggacctcaaggacaacCggatgaaggagctggaggcc	15	10	1	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:15370623C>T	uc001avm.3	+	4	975	c.694C>T	c.(694-696)CGG>TGG	p.R232W	KAZ_uc009vog.1_Missense_Mutation_p.R232W|KAZ_uc010obj.1_Missense_Mutation_p.R232W|KAZ_uc001avo.2_Missense_Mutation_p.R226W|KAZ_uc001avp.2_Missense_Mutation_p.R138W|KAZ_uc001avq.2_Missense_Mutation_p.R138W|KAZ_uc001avr.2_Missense_Mutation_p.R135W	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	232	Interaction with PPL.|Potential.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						CAAGGACAACCGGATGAAGGA	0.677													T	15370623	T	T	15370623	3	4	248	1	0	0	0	0	1	0	0	0	7988	643	23	2	920	2	KAZ	1	15370623	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	14221195	15370623	233879998	2	17700											
HP1BP3	50809	broad.mit.edu	37	chr1	21106920	21106921	+	Frame_Shift_Ins	INS	-	T	T													gacgagttcaccttgagacgINStatcagtcgccattttaaat							TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:21106920_21106921insT	uc001bdw.1	-	2	153_154	c.13_14insA	c.(13-15)ACGfs	p.T5fs	HP1BP3_uc001bdv.1_5'UTR|HP1BP3_uc010odh.1_Intron|HP1BP3_uc001bdy.1_Frame_Shift_Ins_p.T5fs|HP1BP3_uc001bdz.2_RNA|HP1BP3_uc001bea.2_Frame_Shift_Ins_p.T5fs|HP1BP3_uc001beb.2_Frame_Shift_Ins_p.T5fs	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	5					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		ACCTTGAGACGTATCAGTCGCC	0.475													T	21106921	T	T	21106920	7	5	248	1	0	1	1	0	0	0	0	0	7328	1145	40	0	1695	0	HP1BP3	1	21106920	Frame_Shift_Ins	INS	-	TCGA-41-3915-01A-01D-1353-08	5736297	21106920	228143701	3	17701											
ARID1A	8289	broad.mit.edu	37	chr1	27092731	27092731	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggccgccaggctaccccaatAtgaatcaagggggcatgatg	13	11	1	2	rs141432631		TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:27092731A>G	uc001bmv.1	+	9	3125	c.2752A>G	c.(2752-2754)ATG>GTG	p.M918V	ARID1A_uc001bmt.1_Missense_Mutation_p.M918V|ARID1A_uc001bmu.1_Missense_Mutation_p.M918V|ARID1A_uc001bmw.1_Missense_Mutation_p.M535V	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	918					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTACCCCAATATGAATCAAGG	0.483			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								G	27092731	G	G	27092731	3	3	248	1	0	0	0	0	1	0	0	0	913	449	16	4	2786	4	ARID1A	1	27092731	Missense_Mutation	SNP	A	TCGA-41-3915-01A-01D-1353-08	5985811	27092731	222157890	4	17702											
RNF19B	127544	broad.mit.edu	37	chr1	33408041	33408042	+	Frame_Shift_Ins	INS	-	GC	GC													caatgctgggattcttgaggINSgctctccaggcatctgccac							TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:33408041_33408042insGC	uc010oho.1	-	7	1424_1425	c.1424_1425insGC	c.(1423-1425)GCCfs	p.A475fs	RNF19B_uc001bwm.3_Frame_Shift_Ins_p.A474fs|RNF19B_uc010ohp.1_Frame_Shift_Ins_p.A474fs	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	475						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GATTCTTGAGGGCTCTCCAGGC	0.475													GC	33408042	GC	GC	33408041	7	5	248	1	0	1	1	0	0	0	0	0	13471	1219	43	0	811	0	RNF19B	1	33408041	Frame_Shift_Ins	INS	-	TCGA-41-3915-01A-01D-1353-08	6315310	33408041	215842580	5	17703											
FAM159A	348378	broad.mit.edu	37	chr1	53099192	53099192	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ggcgcctgcacgagctacgtGagcgcagagcaggaggtggt	18	10	0	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:53099192G>C	uc001cuf.2	+	1	127	c.27G>C	c.(25-27)GTG>GTC	p.V9V	FAM159A_uc001cug.1_RNA|FAM159A_uc001cuh.2_RNA	NM_001042693	NP_001036158	Q6UWV7	F159A_HUMAN	hypothetical protein LOC348378	9						integral to membrane					0						CGAGCTACGTGAGCGCAGAGC	0.617													C	53099192	C	C	53099192	2	2	248	1	0	0	0	0	0	0	0	1	5468	1277	45	5		5	FAM159A	1	53099192	Silent	SNP	G	TCGA-41-3915-01A-01D-1353-08	19691151	53099192	196151429	6	17704											
WDR63	126820	broad.mit.edu	37	chr1	85559260	85559260	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tacccacctgaaagagtaccAgtcctttaccgaccttcata	5	14	1	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:85559260A>T	uc001dkt.2	+	9	1168	c.977A>T	c.(976-978)CAG>CTG	p.Q326L	WDR63_uc009wcl.2_Missense_Mutation_p.Q287L	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	326										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		AAAGAGTACCAGTCCTTTACC	0.438													T	85559260	T	T	85559260	3	4	248	1	0	0	0	0	1	0	0	0	17311	188	7	5	1007	5	WDR63	1	85559260	Missense_Mutation	SNP	A	TCGA-41-3915-01A-01D-1353-08	32460068	85559260	163691361	7	17705											
WDR63	126820	broad.mit.edu	37	chr1	85592202	85592202	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttgtttaaagactggaccGctccttcagtcatgctgtgc	9	10	2	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:85592202G>A	uc001dkt.2	+	20	2312	c.2121G>A	c.(2119-2121)CCG>CCA	p.P707P	WDR63_uc009wcl.2_Silent_p.P668P	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	707	WD 3.									upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		AGACTGGACCGCTCCTTCAGT	0.423													A	85592202	A	A	85592202	2	1	248	1	0	0	0	0	0	0	0	1	17311	1074	38	1		1	WDR63	1	85592202	Silent	SNP	G	TCGA-41-3915-01A-01D-1353-08	32942	85592202	163658419	8	17706											
TDRKH	11022	broad.mit.edu	37	chr1	151748582	151748582	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagcactgacctgagagcccTgaggtccttcagtgggcaat	12	12	1	3			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:151748582T>C	uc009wnb.1	-	8	1389	c.1207A>G	c.(1207-1209)AGG>GGG	p.R403G	TDRKH_uc001eyy.2_Missense_Mutation_p.R179G|TDRKH_uc001ezb.3_Missense_Mutation_p.R399G|TDRKH_uc001ezc.3_Missense_Mutation_p.R358G|TDRKH_uc001eza.3_Missense_Mutation_p.R403G|TDRKH_uc001ezd.3_Missense_Mutation_p.R403G|TDRKH_uc010pdn.1_Missense_Mutation_p.R179G	NM_006862	NP_006853	Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing isoform a	403	Tudor.						RNA binding			ovary(1)|pancreas(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTGAGAGCCCTGAGGTCCTTC	0.537													C	151748582	C	C	151748582	3	2	248	1	0	0	0	0	1	0	0	0	15734	1579	55	4	502	4	TDRKH	1	151748582	Missense_Mutation	SNP	T	TCGA-41-3915-01A-01D-1353-08	66156380	151748582	97502039	9	17707											
CR2	1380	broad.mit.edu	37	chr1	207643227	207643227	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtcagaagactgggacctgGagtggccctgccccacgctg	14	13	1	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:207643227G>A	uc001hfw.2	+	6	1099	c.1005G>A	c.(1003-1005)TGG>TGA	p.W335*	CR2_uc001hfv.2_Nonsense_Mutation_p.W335*|CR2_uc009xch.2_Nonsense_Mutation_p.W335*|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	335	Sushi 5.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						CTGGGACCTGGAGTGGCCCTG	0.522													A	207643227	A	A	207643227	4	1	248	1	0	0	0	0	0	1	0	0	3842	1183	41	3	1027	3	CR2	1	207643227	Nonsense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	55894645	207643227	41607394	10	17708											
OR1C1	26188	broad.mit.edu	37	chr1	247920937	247920937	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatgaagggctgaaatagaCggcgatggctgtgccgtaaa	16	6	0	3			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr1:247920937C>T	uc010pza.1	-	1	772	c.772G>A	c.(772-774)GTC>ATC	p.V258I		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	258	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CTGAAATAGACGGCGATGGCT	0.512													T	247920937	T	T	247920937	3	4	248	1	0	0	0	0	1	0	0	0	10952	536	19	1	174	1	OR1C1	1	247920937	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	40277710	247920937	1329684	11	17709											
SPATS2L	26010	broad.mit.edu	37	chr2	201332021	201332021	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttatttggcagtggaaatcCtgactgctcgtcagaagaaa	10	8	1	3			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr2:201332021C>T	uc002uvn.3	+	10	1208	c.856C>T	c.(856-858)CTG>TTG	p.L286L	SPATS2L_uc010fst.2_Silent_p.L286L|SPATS2L_uc002uvo.3_Silent_p.L226L|SPATS2L_uc002uvp.3_Silent_p.L286L|SPATS2L_uc002uvq.3_Silent_p.L217L|SPATS2L_uc002uvr.3_Silent_p.L286L|SPATS2L_uc010zhc.1_Silent_p.L316L	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	286	Potential.					cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						AGTGGAAATCCTGACTGCTCG	0.438													T	201332021	T	T	201332021	2	4	248	1	0	0	0	0	0	0	0	1	15019	680	24	3		3	SPATS2L	2	201332021	Silent	SNP	C	TCGA-41-3915-01A-01D-1353-08		201332021	41867352	12	17710											
RAPH1	65059	broad.mit.edu	37	chr2	204320201	204320201	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atagtagataccagatgctcGcaagagaaaataacgctttt	8	7	0	3			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr2:204320201G>A	uc002vad.2	-	9	1486	c.1261C>T	c.(1261-1263)CGA>TGA	p.R421*	RAPH1_uc002vae.2_Nonsense_Mutation_p.R473*|RAPH1_uc002vaf.2_Nonsense_Mutation_p.R473*	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	421	PH.				cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						CCAGATGCTCGCAAGAGAAAA	0.383													A	204320201	A	A	204320201	4	1	248	1	0	0	0	0	0	1	0	0	13050	1095	38	1	2522	1	RAPH1	2	204320201	Nonsense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	2988180	204320201	38879172	13	17711											
DGKD	8527	broad.mit.edu	37	chr2	234344488	234344488	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaatttaaggcccacaagcGctgtgctgtgcgtgcaacca	10	12	0	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr2:234344488G>A	uc002vui.1	+	6	623	c.611G>A	c.(610-612)CGC>CAC	p.R204H	DGKD_uc002vuj.1_Missense_Mutation_p.R160H|DGKD_uc010fyh.1_Missense_Mutation_p.R71H|DGKD_uc010fyi.1_5'Flank|DGKD_uc002vuk.1_Missense_Mutation_p.R71H	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	204	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GCCCACAAGCGCTGTGCTGTG	0.507													A	234344488	A	A	234344488	3	1	248	1	0	0	0	0	1	0	0	0	4467	1087	38	1	657	1	DGKD	2	234344488	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	30024287	234344488	8854885	14	17712											
COL6A3	1293	broad.mit.edu	37	chr2	238305417	238305417	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taggaaagcctgagagaaagAggcaaaagacggccactaag	13	7	0	4			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr2:238305417A>G	uc002vwl.2	-	2	329	c.44T>C	c.(43-45)CTC>CCC	p.L15P	COL6A3_uc002vwo.2_Missense_Mutation_p.L15P|COL6A3_uc010znj.1_Missense_Mutation_p.L15P|COL6A3_uc002vwq.2_Missense_Mutation_p.L15P|COL6A3_uc002vwr.2_Missense_Mutation_p.L15P|COL6A3_uc010znk.1_Missense_Mutation_p.L15P	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	15					axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGAGAGAAAGAGGCAAAAGAC	0.423													G	238305417	G	G	238305417	3	3	248	1	0	0	0	0	1	0	0	0	3701	304	11	4	9708	4	COL6A3	2	238305417	Missense_Mutation	SNP	A	TCGA-41-3915-01A-01D-1353-08	3960929	238305417	4893956	15	17713											
NCAPG	64151	broad.mit.edu	37	chr4	17825349	17825349	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggtttcttttcttgttgaaAgactactccacatcattata	5	8	3	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr4:17825349A>G	uc003gpp.2	+	9	1515	c.1339A>G	c.(1339-1341)AGA>GGA	p.R447G	NCAPG_uc011bxj.1_5'UTR	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	447	HEAT 7.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		TCTTGTTGAAAGACTACTCCA	0.323													G	17825349	G	G	17825349	3	3	248	1	0	0	0	0	1	0	0	0	10207	64	3	4	1373	4	NCAPG	4	17825349	Missense_Mutation	SNP	A	TCGA-41-3915-01A-01D-1353-08		17825349	173328927	16	17714											
GC	2638	broad.mit.edu	37	chr4	72620754	72620754	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gcattcaccaaggctttttaGggttggctcaagtaccttac	9	10	2	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr4:72620754G>C	uc003hge.2	-	9	1258	c.1105C>G	c.(1105-1107)CTA>GTA	p.L369V	GC_uc003hgd.2_Missense_Mutation_p.L247V|GC_uc010iie.2_Missense_Mutation_p.L369V|GC_uc010iif.2_Missense_Mutation_p.L388V	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	369	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	AGGCTTTTTAGGGTTGGCTCA	0.378													C	72620754	C	C	72620754	3	2	248	1	0	0	0	0	1	0	0	0	6282	991	35	5	335	5	GC	4	72620754	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	54795405	72620754	118533522	17	17715											
C4orf22	255119	broad.mit.edu	37	chr4	81504250	81504250	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatctgccttttacaggacGctaacaagtgctggtaaaga	10	8	1	2	rs141410009	by1000genomes	TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr4:81504250G>A	uc003hmf.2	+	3	295	c.246G>A	c.(244-246)ACG>ACA	p.T82T	C4orf22_uc010ijp.2_Silent_p.T82T	NM_152770	NP_689983	Q6V702	CD022_HUMAN	hypothetical protein LOC255119	82										skin(2)	2						TTTACAGGACGCTAACAAGTG	0.383													A	81504250	A	A	81504250	2	1	248	1	0	0	0	0	0	0	0	1	2255	1074	38	1		1	C4orf22	4	81504250	Silent	SNP	G	TCGA-41-3915-01A-01D-1353-08	8883496	81504250	109650026	18	17716											
PRKG2	5593	broad.mit.edu	37	chr4	82125882	82125882	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaccaatccagaggtcttcCggtggacctcaagaggcact	11	12	2	3			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr4:82125882C>T	uc003hmh.2	-	1	334	c.320G>A	c.(319-321)CGG>CAG	p.R107Q	PRKG2_uc011cch.1_Missense_Mutation_p.R107Q	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	107					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						AGAGGTCTTCCGGTGGACCTC	0.562													T	82125882	T	T	82125882	3	4	248	1	0	0	0	0	1	0	0	0	12523	652	23	2	2040	2	PRKG2	4	82125882	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	621632	82125882	109028394	19	17717											
ADCY2	108	broad.mit.edu	37	chr5	7709333	7709333	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcaccccaagggagaacgaCggagcccccagcatctcttc	9	17	2	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr5:7709333C>T	uc003jdz.1	+	10	1478	c.1411C>T	c.(1411-1413)CGG>TGG	p.R471W	ADCY2_uc011cmo.1_Missense_Mutation_p.R291W	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	471	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGGAGAACGACGGAGCCCCCA	0.587													T	7709333	T	T	7709333	3	4	248	1	0	0	0	0	1	0	0	0	294	527	19	1	1449	1	ADCY2	5	7709333	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08		7709333	173205927	20	17718											
PIK3R1	5295	broad.mit.edu	37	chr5	67589298	67589298	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gaaattactttatccagtatCcaaataccaacaggtaataa	4	8	0	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr5:67589298C>A	uc003jva.2	+	10	1846	c.1286C>A	c.(1285-1287)TCC>TAC	p.S429Y	PIK3R1_uc003jvb.2_Missense_Mutation_p.S429Y|PIK3R1_uc003jvc.2_Missense_Mutation_p.S129Y|PIK3R1_uc003jvd.2_Missense_Mutation_p.S159Y|PIK3R1_uc003jve.2_Missense_Mutation_p.S108Y|PIK3R1_uc011crb.1_Missense_Mutation_p.S99Y	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	429					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TATCCAGTATCCAAATACCAA	0.318			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			A	67589298	A	A	67589298	3	1	248	1	0	0	0	0	1	0	0	0	11918	855	30	5	1450	5	PIK3R1	5	67589298	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	59879965	67589298	113325962	21	17719											
PCDHB12	56124	broad.mit.edu	37	chr5	140588488	140588488	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaaagaagctatggaaaaCggaggggcaggcactctgca	15	7	1	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr5:140588488C>T	uc003liz.2	+	1	198	c.9C>T	c.(7-9)AAC>AAT	p.N3N	PCDHB12_uc011dak.1_Translation_Start_Site	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	3					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTATGGAAAACGGAGGGGCAG	0.493													T	140588488	T	T	140588488	2	4	248	1	0	0	0	0	0	0	0	1	11537	535	19	1		1	PCDHB12	5	140588488	Silent	SNP	C	TCGA-41-3915-01A-01D-1353-08	72999190	140588488	40326772	22	17720											
FOXI1	2299	broad.mit.edu	37	chr5	169533358	169533358	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	attcctactcggctctcatcGccatggccatccacggggca	9	16	1	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr5:169533358G>C	uc003mai.3	+	1	442	c.397G>C	c.(397-399)GCC>CCC	p.A133P	FOXI1_uc003maj.3_Missense_Mutation_p.A133P	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	133	Fork-head.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGCTCTCATCGCCATGGCCAT	0.642									Pendred_syndrome				C	169533358	C	C	169533358	3	2	248	1	0	0	0	0	1	0	0	0	6009	1087	38	5	399	5	FOXI1	5	169533358	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	28944870	169533358	11381902	23	17721											
BEND3	57673	broad.mit.edu	37	chr6	107391897	107391897	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcattcaggagccgcagtgaCgaggggctgttgctggcgtt	16	9	2	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr6:107391897C>T	uc003prs.2	-	5	1148	c.498G>A	c.(496-498)TCG>TCA	p.S166S		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	166										ovary(3)	3						GCCGCAGTGACGAGGGGCTGT	0.567													T	107391897	T	T	107391897	2	4	248	1	0	0	0	0	0	0	0	1	1399	523	19	1		1	BEND3	6	107391897	Silent	SNP	C	TCGA-41-3915-01A-01D-1353-08		107391897	63723170	24	17722											
ANKIB1	54467	broad.mit.edu	37	chr7	91991520	91991520	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gagtgccttggtgaagcacaTgagccttgtgactgccaaac	12	10	0	3			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr7:91991520T>A	uc003ulw.2	+	10	1795	c.1419T>A	c.(1417-1419)CAT>CAA	p.H473Q		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	473	IBR-type; degenerate.						protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GTGAAGCACATGAGCCTTGTG	0.343													A	91991520	A	A	91991520	3	1	248	1	0	0	0	0	1	0	0	0	630	1461	51	5	1453	5	ANKIB1	7	91991520	Missense_Mutation	SNP	T	TCGA-41-3915-01A-01D-1353-08		91991520	67147143	25	17723											
PRSS37	136242	broad.mit.edu	37	chr7	141536273	141536273	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atgccgacgtcccctcccatGaagtgccccacctcgattcc	7	19	0	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr7:141536273G>T	uc003vws.1	-	5	1002	c.630C>A	c.(628-630)TTC>TTA	p.F210L	PRSS37_uc011krk.1_Missense_Mutation_p.F197L|PRSS37_uc011krl.1_Missense_Mutation_p.F209L|PRSS37_uc003vwt.1_Missense_Mutation_p.F197L	NM_001008270	NP_001008271	A4D1T9	PRS37_HUMAN	protease, serine, 37 precursor	210	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			skin(1)	1						CCCCTCCCATGAAGTGCCCCA	0.458													T	141536273	T	T	141536273	3	4	248	1	0	0	0	0	1	0	0	0	12626	1281	45	5	81	5	PRSS37	7	141536273	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	49544753	141536273	17602390	26	17724											
DOCK5	80005	broad.mit.edu	37	chr8	25199986	25199986	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cggcagaaacttaactgcatGaccaagatagtagagagcac	10	9	0	4			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr8:25199986G>C	uc003xeg.2	+	25	2717	c.2580G>C	c.(2578-2580)ATG>ATC	p.M860I	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.M574I|DOCK5_uc003xei.2_Missense_Mutation_p.M430I|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	860						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TTAACTGCATGACCAAGATAG	0.373													C	25199986	C	C	25199986	3	2	248	1	0	0	0	0	1	0	0	0	4690	1290	45	5	2678	5	DOCK5	8	25199986	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08		25199986	121164036	27	17725											
POTEA	340441	broad.mit.edu	37	chr8	43171085	43171085	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gccacaaaggcttaaaggaaGtgaaaatagtcagcatgagg	12	6	1	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr8:43171085G>C	uc003xpz.1	+	7	999	c.956G>C	c.(955-957)AGT>ACT	p.S319T	POTEA_uc003xqa.1_Missense_Mutation_p.S273T	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	319										ovary(1)	1						CTTAAAGGAAGTGAAAATAGT	0.303													C	43171085	C	C	43171085	3	2	248	1	0	0	0	0	1	0	0	0	12261	1029	36	5	982	5	POTEA	8	43171085	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	17971099	43171085	103192937	28	17726											
ADAMTSL1	92949	broad.mit.edu	37	chr9	18574217	18574217	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctaaggtcttagatggtacgCgttgctatacagaatctttg	10	7	2	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr9:18574217C>T	uc003zne.3	+	4	554	c.427C>T	c.(427-429)CGT>TGT	p.R143C	ADAMTSL1_uc003znb.2_Missense_Mutation_p.R143C|ADAMTSL1_uc003znc.3_Missense_Mutation_p.R143C	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	143						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		AGATGGTACGCGTTGCTATAC	0.438													T	18574217	T	T	18574217	3	4	248	1	0	0	0	0	1	0	0	0	274	768	27	1	441	1	ADAMTSL1	9	18574217	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08		18574217	122639214	29	17727											
IFNW1	3467	broad.mit.edu	37	chr9	21141168	21141168	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgcagggctgctaattgcCccagcagattctccttctcc	9	14	2	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr9:21141168C>T	uc003zol.1	-	1	977	c.402G>A	c.(400-402)GGG>GGA	p.G134G		NM_002177	NP_002168	P05000	IFNW1_HUMAN	interferon, omega 1 precursor	134					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding				0				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TGCTAATTGCCCCAGCAGATT	0.527													T	21141168	T	T	21141168	2	4	248	1	0	0	0	0	0	0	0	1	7552	610	22	3		3	IFNW1	9	21141168	Silent	SNP	C	TCGA-41-3915-01A-01D-1353-08	2566951	21141168	120072263	30	17728											
ST6GALNAC4	27090	broad.mit.edu	37	chr9	130674960	130674960	+	Splice_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagggctcgcggaccagcggCtgcagggcaggcagggagaa	19	11	0	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr9:130674960C>A	uc004bss.2	-	4	475	c.199_splice	c.e4-1	p.P67_splice	ST6GALNAC4_uc004bst.2_Splice_Site	NM_175039	NP_778204	Q9H4F1	SIA7D_HUMAN	sialyltransferase 7D isoform a						glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity				0						GGACCAGCGGCTGCAGGGCAG	0.632													A	130674960	A	A	130674960	5	1	248	1	0	0	0	0	0	0	1	0	15225	811	28	5	722	5	ST6GALNAC4	9	130674960	Splice_Site	SNP	C	TCGA-41-3915-01A-01D-1353-08	109533792	130674960	10538471	31	17729											
PTEN	5728	broad.mit.edu	37	chr10	89692905	89692905	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgtaaagctggaaagggacGaactggtgtaatgatatgtg	14	4	0	1	rs121913292		TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr10:89692905G>A	uc001kfb.2	+	6	1420	c.389G>A	c.(388-390)CGA>CAA	p.R130Q		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).	R->M: Does not affect the ability to inhibit AKT/PKB activation.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130G(65)|p.R130*(61)|p.R130Q(43)|p.R130fs*4(12)|p.R130L(7)|p.R55fs*1(4)|p.R130P(4)|p.K128_R130del(3)|p.Y27_N212>Y(2)|p.?(2)|p.Y27fs*1(2)|p.R130R(1)|p.K128fs*47(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.T131fs*50(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGAAAGGGACGAACTGGTGTA	0.403	R130Q(MDAPCA2B_PROSTATE)|R130Q(MFE296_ENDOMETRIUM)|R130fs*4(AN3CA_ENDOMETRIUM)|R130Q(JHUEM1_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89692905	A	A	89692905	3	1	248	1	0	0	0	0	1	0	0	0	12738	1058	37	2	407	2	PTEN	10	89692905	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08		89692905	45841842	32	17730											
PDZD7	79955	broad.mit.edu	37	chr10	102789812	102789812	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatgaggctcggattccgcgGgggggcccgttcagcagccg	18	12	1	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr10:102789812G>T	uc001kso.1	-	2	380	c.165C>A	c.(163-165)CCC>CCA	p.P55P	PDZD7_uc001ksn.2_Silent_p.P55P|SFXN3_uc001ksp.2_5'Flank|SFXN3_uc001ksq.2_5'Flank|SFXN3_uc010qpx.1_5'Flank	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	55						cilium|nucleus	protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		GGATTCCGCGGGGGGGCCCGT	0.662													T	102789812	T	T	102789812	2	4	248	1	0	0	0	0	0	0	0	1	11704	1219	43	5		5	PDZD7	10	102789812	Silent	SNP	G	TCGA-41-3915-01A-01D-1353-08	13096907	102789812	32744935	33	17731											
HPS6	79803	broad.mit.edu	37	chr10	103827208	103827208	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctggatgctggcctggccctCggcccctccagtcccctgct	11	19	0	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr10:103827208C>G	uc001kuj.2	+	1	2062	c.1977C>G	c.(1975-1977)CTC>CTG	p.L659L		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	659						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		GCCTGGCCCTCGGCCCCTCCA	0.617									Hermansky-Pudlak_syndrome				G	103827208	G	G	103827208	2	3	248	1	0	0	0	0	0	0	0	1	7343	871	31	5		5	HPS6	10	103827208	Silent	SNP	C	TCGA-41-3915-01A-01D-1353-08	1037396	103827208	31707539	34	17732											
KIAA1598	57698	broad.mit.edu	37	chr10	118728190	118728190	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaattcttccagttttttaaCggcttcatctcgttcttgcc	5	11	4	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr10:118728190C>T	uc009xyw.2	-	3	643	c.145G>A	c.(145-147)GTT>ATT	p.V49I	KIAA1598_uc001lcz.3_Missense_Mutation_p.V49I|KIAA1598_uc010qso.1_5'UTR|KIAA1598_uc010qsp.1_Missense_Mutation_p.V49I|KIAA1598_uc010qsq.1_5'UTR|KIAA1598_uc001lcy.3_Missense_Mutation_p.V19I	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	49	Potential.				axon guidance	axon					0				all cancers(201;0.00494)		AGTTTTTTAACGGCTTCATCT	0.323													T	118728190	T	T	118728190	3	4	248	1	0	0	0	0	1	0	0	0	8246	536	19	1	1810	1	KIAA1598	10	118728190	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	14900982	118728190	16806557	35	17733											
SYCE1	93426	broad.mit.edu	37	chr10	135370273	135370273	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agggactcacgtggaagtccCagaggtccttgtgctggccc	14	12	1	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr10:135370273C>A	uc001lno.2	-	8	623	c.518G>T	c.(517-519)TGG>TTG	p.W173L	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Missense_Mutation_p.W45L|SYCE1_uc009ybn.2_Missense_Mutation_p.W173L|SYCE1_uc001lnn.2_Missense_Mutation_p.W137L	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	173	Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GTGGAAGTCCCAGAGGTCCTT	0.512													A	135370273	A	A	135370273	3	1	248	1	0	0	0	0	1	0	0	0	15425	595	21	5	604	5	SYCE1	10	135370273	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	16642083	135370273	164474	36	17734											
DENND5A	23258	broad.mit.edu	37	chr11	9171674	9171674	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcttcaggtgtctggaaaGtaactttttttccatggaca	9	8	2	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr11:9171674G>A	uc001mhl.2	-	15	2944	c.2689C>T	c.(2689-2691)CTT>TTT	p.L897F	DENND5A_uc001mhk.2_Missense_Mutation_p.L240F|DENND5A_uc010rbw.1_Missense_Mutation_p.L897F|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	897	RUN 1.									liver(1)	1						TGTCTGGAAAGTAACTTTTTT	0.517													A	9171674	A	A	9171674	3	1	248	1	0	0	0	0	1	0	0	0	4436	1029	36	3	1210	3	DENND5A	11	9171674	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08		9171674	125834842	37	17735											
OR4C11	219429	broad.mit.edu	37	chr11	55371464	55371464	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctcatgatggttgggtaaCgcaagggcttacagatggcc	15	8	1	2	rs146220981	byFrequency	TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr11:55371464C>T	uc010rii.1	-	1	386	c.386G>A	c.(385-387)CGT>CAT	p.R129H		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTTGGGTAACGCAAGGGCTT	0.458													T	55371464	T	T	55371464	3	4	248	1	0	0	0	0	1	0	0	0	11045	536	19	1	548	1	OR4C11	11	55371464	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	46199790	55371464	79635052	38	17736											
PRG2	5553	broad.mit.edu	37	chr11	57156544	57156544	+	Missense_Mutation	SNP	G	A	A													agcggcaggtctggcacccaGggatgcccaccacttttact							TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr11:57156544G>A	uc001njz.2	-	2	332	c.305C>T	c.(304-306)CCT>CTT	p.P102L	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.P102L|PRG2_uc001nkb.2_Missense_Mutation_p.P102L|PRG2_uc001nkd.2_Missense_Mutation_p.P102L|PRG2_uc001nkc.2_Missense_Mutation_p.P102L|PRG2_uc001nke.2_Missense_Mutation_p.P382L	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	102					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	CTGGCACCCAGGGATGCCCAC	0.532													A	57156544	A	A	57156544	3	1	248	1	0	0	0	0	1	0	0	0	12479	1000	35	3	379	3	PRG2	11	57156544	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	1785080	57156544	77849972	39	17737	22	2									
PRG2	5553	broad.mit.edu	37	chr11	57156546	57156546	+	Silent	SNP	G	A	A													cggcaggtctggcacccaggGatgcccaccacttttactgt							TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr11:57156546G>A	uc001njz.2	-	2	330	c.303C>T	c.(301-303)ATC>ATT	p.I101I	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Silent_p.I101I|PRG2_uc001nkb.2_Silent_p.I101I|PRG2_uc001nkd.2_Silent_p.I101I|PRG2_uc001nkc.2_Silent_p.I101I|PRG2_uc001nke.2_Silent_p.I381I	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	101					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	GGCACCCAGGGATGCCCACCA	0.537													A	57156546	A	A	57156546	2	1	248	1	0	0	0	0	0	0	0	1	12479	1164	41	3		3	PRG2	11	57156546	Silent	SNP	G	TCGA-41-3915-01A-01D-1353-08	2	57156546	77849970	40	17738	22	2									
MS4A14	84689	broad.mit.edu	37	chr11	60184319	60184319	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caattccaaaatgttcaagcCgaaggacagcaagctcaggt	9	10	2	0	rs147367847	byFrequency	TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr11:60184319C>T	uc001npj.2	+	5	2443	c.1878C>T	c.(1876-1878)GCC>GCT	p.A626A	MS4A14_uc001npi.2_Silent_p.A514A|MS4A14_uc001npn.2_Silent_p.A364A|MS4A14_uc001npk.2_Silent_p.A609A|MS4A14_uc001npl.2_Silent_p.A364A|MS4A14_uc001npm.2_Silent_p.A364A	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	626	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						ATGTTCAAGCCGAAGGACAGC	0.458													T	60184319	T	T	60184319	2	4	248	1	0	0	0	0	0	0	0	1	9858	639	23	2		2	MS4A14	11	60184319	Silent	SNP	C	TCGA-41-3915-01A-01D-1353-08	3027773	60184319	74822197	41	17739											
MEN1	4221	broad.mit.edu	37	chr11	64572600	64572600	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcctcccatttgcagatgCcgtcgtagaatcgcagcagg	10	14	0	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr11:64572600C>T	uc001obj.2	-	9	1344	c.1271G>A	c.(1270-1272)GGC>GAC	p.G424D	MAP4K2_uc001obh.2_5'Flank|MAP4K2_uc001obi.2_5'Flank|MAP4K2_uc010rnp.1_5'Flank|MEN1_uc001obk.2_Missense_Mutation_p.G424D|MEN1_uc001obl.2_Missense_Mutation_p.G384D|MEN1_uc001obm.2_Missense_Mutation_p.G419D|MEN1_uc001obn.2_Missense_Mutation_p.G424D|MEN1_uc001obo.2_Missense_Mutation_p.G424D|MEN1_uc001obp.2_Missense_Mutation_p.G419D|MEN1_uc001obq.2_Missense_Mutation_p.G424D|MEN1_uc001obr.2_Missense_Mutation_p.G424D	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	424			Missing (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.L414_E425del(1)|p.G419fs*26(1)		parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						TTTGCAGATGCCGTCGTAGAA	0.637			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				T	64572600	T	T	64572600	3	4	248	1	0	0	0	0	1	0	0	0	9472	739	26	3	584	3	MEN1	11	64572600	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	4388281	64572600	70433916	42	17740											
KDM4DL	390245	broad.mit.edu	37	chr11	94758834	94758834	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgttgcttacatggagtcccAaggcgcacatcaagctggcc	11	12	1	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr11:94758834A>G	uc010ruf.1	+	1	413	c.113A>G	c.(112-114)CAA>CGA	p.Q38R		NM_001161630	NP_001155102	B2RXH2	KD4DL_HUMAN	lysine (K)-specific demethylase 4D-like	38	JmjN.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ATGGAGTCCCAAGGCGCACAT	0.463													G	94758834	G	G	94758834	3	3	248	1	0	0	0	0	1	0	0	0	8132	130	5	4	115	4	KDM4DL	11	94758834	Missense_Mutation	SNP	A	TCGA-41-3915-01A-01D-1353-08	30186234	94758834	40247682	43	17741											
ATM	472	broad.mit.edu	37	chr11	108183214	108183214	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaagtaaagaagaaactggaAtaagtttacaggtaaatatt	8	2	0	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr11:108183214A>G	uc001pkb.1	+	40	6380	c.5995A>G	c.(5995-5997)ATA>GTA	p.I1999V	ATM_uc009yxr.1_Missense_Mutation_p.I1999V|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.I651V|ATM_uc001pkg.1_Missense_Mutation_p.I356V|ATM_uc009yxt.1_Missense_Mutation_p.I113V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1999	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGAAACTGGAATAAGTTTACA	0.328			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			G	108183214	G	G	108183214	3	3	248	1	0	0	0	0	1	0	0	0	1109	101	4	4	6149	4	ATM	11	108183214	Missense_Mutation	SNP	A	TCGA-41-3915-01A-01D-1353-08	13424380	108183214	26823302	44	17742											
IFLTD1	160492	broad.mit.edu	37	chr12	25699396	25699396	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgagtgtgctgtaagtttctTtgaatcaccaaacaaagaaa	8	6	2	3			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr12:25699396T>C	uc001rgs.2	-	3	490	c.340A>G	c.(340-342)AAG>GAG	p.K114E	IFLTD1_uc001rgt.1_Missense_Mutation_p.K17E|IFLTD1_uc010sji.1_Missense_Mutation_p.K135E|IFLTD1_uc010sjj.1_Missense_Mutation_p.K51E|IFLTD1_uc009zjc.2_Missense_Mutation_p.K135E	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	114						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					GTAAGTTTCTTTGAATCACCA	0.373													C	25699396	C	C	25699396	3	2	248	1	0	0	0	0	1	0	0	0	7530	1850	64	4	850	4	IFLTD1	12	25699396	Missense_Mutation	SNP	T	TCGA-41-3915-01A-01D-1353-08		25699396	108152499	45	17743											
CPNE8	144402	broad.mit.edu	37	chr12	39268300	39268300	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agatttagaaaatgtgtctcTgtcaagaagatttctgttga	9	4	3	5			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr12:39268300T>A	uc001rls.1	-	2	196	c.112A>T	c.(112-114)AGA>TGA	p.R38*		NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	38	C2 1.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				AATGTGTCTCTGTCAAGAAGA	0.264													A	39268300	A	A	39268300	4	1	248	1	0	0	0	0	0	1	0	0	3818	1588	55	5	1658	5	CPNE8	12	39268300	Nonsense_Mutation	SNP	T	TCGA-41-3915-01A-01D-1353-08	13568904	39268300	94583595	46	17744											
DIP2B	57609	broad.mit.edu	37	chr12	51102260	51102260	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttttctgtgtctgtattttAtgatgagcgcattgtggtgg	13	4	2	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr12:51102260A>G	uc001rwv.2	+	22	2720	c.2564A>G	c.(2563-2565)TAT>TGT	p.Y855C	DIP2B_uc009zlt.2_Missense_Mutation_p.Y285C	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	855						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TCTGTATTTTATGATGAGCGC	0.448													G	51102260	G	G	51102260	3	3	248	1	0	0	0	0	1	0	0	0	4528	449	16	4	2650	4	DIP2B	12	51102260	Missense_Mutation	SNP	A	TCGA-41-3915-01A-01D-1353-08	11833960	51102260	82749635	47	17745											
SDR9C7	121214	broad.mit.edu	37	chr12	57324008	57324008	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttcagtaccagggcccagttAccttatgctgtcagagaagg	11	10	2	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr12:57324008A>G	uc010sqw.1	-	2	560	c.560_splice	c.e2+1	p.R187_splice		NM_148897	NP_683695	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C,							cytoplasm	binding|oxidoreductase activity			central_nervous_system(1)	1						GGGCCCAGTTACCTTATGCTG	0.537													G	57324008	G	G	57324008	5	3	248	1	0	0	0	0	0	0	1	0	13974	405	14	4	391	4	SDR9C7	12	57324008	Splice_Site	SNP	A	TCGA-41-3915-01A-01D-1353-08	6221748	57324008	76527887	48	17746											
TUBA3C	7278	broad.mit.edu	37	chr13	19748215	19748215	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggcctccgcgatggccgtggTgttgctcagcatgcacacag	14	13	1	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr13:19748215T>A	uc009zzj.2	-	5	1190	c.1141A>T	c.(1141-1143)ACC>TCC	p.T381S		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	381					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ATGGCCGTGGTGTTGCTCAGC	0.627													A	19748215	A	A	19748215	3	1	248	1	0	0	0	0	1	0	0	0	16743	1696	59	5	215	5	TUBA3C	13	19748215	Missense_Mutation	SNP	T	TCGA-41-3915-01A-01D-1353-08		19748215	95421663	49	17747											
AHNAK2	113146	broad.mit.edu	37	chr14	105413630	105413630	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gccggctccctcgggaacgtGgccctctgggagtttcacat	13	14	2	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr14:105413630G>T	uc010axc.1	-	7	8278	c.8158C>A	c.(8158-8160)CAC>AAC	p.H2720N	AHNAK2_uc001ypx.2_Missense_Mutation_p.H2620N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2720						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCGGGAACGTGGCCCTCTGGG	0.602													T	105413630	T	T	105413630	3	4	248	1	0	0	0	0	1	0	0	0	415	1348	47	5	9233	5	AHNAK2	14	105413630	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08		105413630	1935910	50	17748											
LBXCOR1	390598	broad.mit.edu	37	chr15	68118619	68118619	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccatctcgtcgcgccgctgCggcatgatcactaagcgaga	11	15	2	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr15:68118619C>T	uc002aqy.1	+	2	426	c.426C>T	c.(424-426)TGC>TGT	p.C142C		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	151					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						CGCGCCGCTGCGGCATGATCA	0.662													T	68118619	T	T	68118619	2	4	248	1	0	0	0	0	0	0	0	1	8655	776	27	1		1	LBXCOR1	15	68118619	Silent	SNP	C	TCGA-41-3915-01A-01D-1353-08		68118619	34412773	51	17749											
ADAMTS7	11173	broad.mit.edu	37	chr15	79083051	79083051	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtcatggtgcaggggatggGcatcccccttcatgttgatg	14	9	2	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr15:79083051G>A	uc002bej.3	-	6	1200	c.989C>T	c.(988-990)GCC>GTC	p.A330V	ADAMTS7_uc010und.1_Missense_Mutation_p.A330V|ADAMTS7_uc002bek.1_Missense_Mutation_p.A330V	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	330	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CAGGGGATGGGCATCCCCCTT	0.592													A	79083051	A	A	79083051	3	1	248	1	0	0	0	0	1	0	0	0	271	1203	42	3	4147	3	ADAMTS7	15	79083051	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	10964432	79083051	23448341	52	17750											
OR4F15	390649	broad.mit.edu	37	chr15	102358715	102358715	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttagccatgctcttggggGcactgagatggtgctgctca	13	10	2	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr15:102358715G>A	uc010uts.1	+	1	326	c.326G>A	c.(325-327)GGC>GAC	p.G109D		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			GCTCTTGGGGGCACTGAGATG	0.458													A	102358715	A	A	102358715	3	1	248	1	0	0	0	0	1	0	0	0	11061	1203	42	3	328	3	OR4F15	15	102358715	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	23275664	102358715	172677	53	17751											
ZFP3	124961	broad.mit.edu	37	chr17	4995064	4995064	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgagaaagaccgggagaatAatgagagtgagagaggctgc	17	4	0	6			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr17:4995064A>G	uc002gaq.2	+	2	390	c.265A>G	c.(265-267)AAT>GAT	p.N89D		NM_153018	NP_694563	Q96NJ6	ZFP3_HUMAN	zinc finger protein-3	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGGGAGAATAATGAGAGTGA	0.468													G	4995064	G	G	4995064	3	3	248	1	0	0	0	0	1	0	0	0	17640	362	13	4	267	4	ZFP3	17	4995064	Missense_Mutation	SNP	A	TCGA-41-3915-01A-01D-1353-08		4995064	76200146	54	17752											
ZNF287	57336	broad.mit.edu	37	chr17	16455757	16455757	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaggcttttccacattcatTacatttataacacttctctc	2	11	2	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr17:16455757T>C	uc002gqi.2	-	6	2152	c.1699A>G	c.(1699-1701)AAT>GAT	p.N567D		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	560	C2H2-type 8.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		CCACATTCATTACATTTATAA	0.353													C	16455757	C	C	16455757	3	2	248	1	0	0	0	0	1	0	0	0	17822	1754	61	4	590	4	ZNF287	17	16455757	Missense_Mutation	SNP	T	TCGA-41-3915-01A-01D-1353-08	11460693	16455757	64739453	55	17753											
RAI1	10743	broad.mit.edu	37	chr17	17697187	17697187	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctccattaccaaaacctcGccaagtatcagcactacggg	6	16	1	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr17:17697187G>A	uc002grm.2	+	3	1394	c.925G>A	c.(925-927)GCC>ACC	p.A309T	RAI1_uc002grn.1_Missense_Mutation_p.A309T	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	309	Gln-rich.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CCAAAACCTCGCCAAGTATCA	0.493													A	17697187	A	A	17697187	3	1	248	1	0	0	0	0	1	0	0	0	13007	1087	38	1	927	1	RAI1	17	17697187	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	1241430	17697187	63498023	56	17754											
KRT37	8688	broad.mit.edu	37	chr17	39577227	39577227	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggcaggcgtggaacagggaTtgcaggggagtctgcaggga	20	6	1	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr17:39577227T>C	uc002hwp.1	-	7	1300	c.1253A>G	c.(1252-1254)AAT>AGT	p.N418S	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	418	Tail.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GGAACAGGGATTGCAGGGGAG	0.547													C	39577227	C	C	39577227	3	2	248	1	0	0	0	0	1	0	0	0	8474	1493	52	4	100	4	KRT37	17	39577227	Missense_Mutation	SNP	T	TCGA-41-3915-01A-01D-1353-08	21880040	39577227	41617983	57	17755											
STXBP4	252983	broad.mit.edu	37	chr17	53237217	53237217	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtgtcctgaatctatctcGctcagaggagaatgaagagg	13	7	3	5			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr17:53237217G>A	uc002iuf.1	+	18	1814	c.1607G>A	c.(1606-1608)CGC>CAC	p.R536H	STXBP4_uc010dcd.1_Missense_Mutation_p.R514H	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	536						cytoplasm	calcium ion binding			ovary(1)	1						AATCTATCTCGCTCAGAGGAG	0.438													A	53237217	A	A	53237217	3	1	248	1	0	0	0	0	1	0	0	0	15354	1087	38	1	1669	1	STXBP4	17	53237217	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	13659990	53237217	27957993	58	17756											
CBX2	84733	broad.mit.edu	37	chr17	77758112	77758112	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgcggcctcgggctggacctGaaggtgaggacgcagaaagg	18	9	0	3			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr17:77758112G>A	uc002jxc.2	+	5	912	c.870G>A	c.(868-870)CTG>CTA	p.L290L		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	290					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGCTGGACCTGAAGGTGAGGA	0.637													A	77758112	A	A	77758112	2	1	248	1	0	0	0	0	0	0	0	1	2718	1277	45	3		3	CBX2	17	77758112	Silent	SNP	G	TCGA-41-3915-01A-01D-1353-08	24520895	77758112	3437098	59	17757											
SPPL2B	56928	broad.mit.edu	37	chr19	2339146	2339146	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaacatggtcatcatcttcAtcatggctgtgggcaccgtc	9	12	5	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr19:2339146A>G	uc002lvs.2	+	5	618	c.538A>G	c.(538-540)ATC>GTC	p.I180V	SPPL2B_uc010dsw.1_Missense_Mutation_p.I152V|SPPL2B_uc010dsy.1_Missense_Mutation_p.I152V|SPPL2B_uc010dsz.1_Missense_Mutation_p.I180V|SPPL2B_uc002lvr.2_Missense_Mutation_p.I180V|SPPL2B_uc010dta.1_Missense_Mutation_p.I33V|SPPL2B_uc002lvu.2_5'Flank	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2	180	Helical; (Potential).					Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CATCATCTTCATCATGGCTGT	0.632													G	2339146	G	G	2339146	3	3	248	1	0	0	0	0	1	0	0	0	15088	217	8	4	556	4	SPPL2B	19	2339146	Missense_Mutation	SNP	A	TCGA-41-3915-01A-01D-1353-08		2339146	56789837	60	17758											
FBXL12	54850	broad.mit.edu	37	chr19	9921852	9921852	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaggcccctcacggtcagcCggatcttgcgcacatctcgg	12	15	4	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr19:9921852C>T	uc002mme.2	-	3	943	c.701G>A	c.(700-702)CGG>CAG	p.R234Q	FBXL12_uc002mmd.2_Missense_Mutation_p.R181Q|FBXL12_uc002mmf.2_Missense_Mutation_p.R181Q|FBXL12_uc002mmg.2_Missense_Mutation_p.R181Q|FBXL12_uc002mmh.2_Missense_Mutation_p.R181Q	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	234	LRR 6.						protein binding			lung(1)|kidney(1)	2						CACGGTCAGCCGGATCTTGCG	0.667													T	9921852	T	T	9921852	3	4	248	1	0	0	0	0	1	0	0	0	5708	652	23	2	283	2	FBXL12	19	9921852	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	7582706	9921852	49207131	61	17759											
S1PR5	53637	broad.mit.edu	37	chr19	10625052	10625052	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctggcagtagatgcgcgcGtagagtgcacagatagcggc	15	10	0	3			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr19:10625052G>A	uc002mot.1	-	2	693	c.636C>T	c.(634-636)TAC>TAT	p.Y212Y	S1PR5_uc002mou.1_Silent_p.Y212Y	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	212	Helical; Name=5; (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						AGATGCGCGCGTAGAGTGCAC	0.697													A	10625052	A	A	10625052	2	1	248	1	0	0	0	0	0	0	0	1	13797	1140	40	1		1	S1PR5	19	10625052	Silent	SNP	G	TCGA-41-3915-01A-01D-1353-08	703200	10625052	48503931	62	17760											
USHBP1	83878	broad.mit.edu	37	chr19	17361108	17361108	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagggcccttgcagtggcttCgagcaccgccacctcctcgg	12	17	0	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr19:17361108C>T	uc002nfs.1	-	13	2151	c.2038G>A	c.(2038-2040)GAA>AAA	p.E680K	USHBP1_uc002nfr.1_Missense_Mutation_p.E306K|USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Missense_Mutation_p.E616K	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	680	Potential.						PDZ domain binding			ovary(1)	1						GCAGTGGCTTCGAGCACCGCC	0.657													T	17361108	T	T	17361108	3	4	248	1	0	0	0	0	1	0	0	0	17034	893	31	2	77	2	USHBP1	19	17361108	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08	6736056	17361108	41767875	63	17761											
IRGC	56269	broad.mit.edu	37	chr19	44223763	44223763	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggctctattcccagtcgtcCgacggcgccatgcgggtggc	14	15	1	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr19:44223763C>T	uc002oxh.2	+	2	1200	c.1053C>T	c.(1051-1053)TCC>TCT	p.S351S		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	351						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CCCAGTCGTCCGACGGCGCCA	0.657													T	44223763	T	T	44223763	2	4	248	1	0	0	0	0	0	0	0	1	7838	639	23	2		2	IRGC	19	44223763	Silent	SNP	C	TCGA-41-3915-01A-01D-1353-08	26862655	44223763	14905220	64	17762											
BCAM	4059	broad.mit.edu	37	chr19	45322375	45322375	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atggcagctggagggaaggaGacgaagtcacactcatctgc	14	9	3	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr19:45322375G>A	uc002ozu.2	+	11	1443	c.1399G>A	c.(1399-1401)GAC>AAC	p.D467N	BCAM_uc002ozt.1_Missense_Mutation_p.D467N	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	467	Extracellular (Potential).|Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				GAGGGAAGGAGACGAAGTCAC	0.597													A	45322375	A	A	45322375	3	1	248	1	0	0	0	0	1	0	0	0	1344	942	33	3	1441	3	BCAM	19	45322375	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	1098612	45322375	13806608	65	17763											
RELB	5971	broad.mit.edu	37	chr19	45515222	45515222	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacgagtacatcaaggagaaCggcttcggcctggacggggg	17	9	1	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr19:45515222C>T	uc002paj.1	+	5	318	c.192C>T	c.(190-192)AAC>AAT	p.N64N		NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	64	Leucine-zipper.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		TCAAGGAGAACGGCTTCGGCC	0.577													T	45515222	T	T	45515222	2	4	248	1	0	0	0	0	0	0	0	1	13217	535	19	1		1	RELB	19	45515222	Silent	SNP	C	TCGA-41-3915-01A-01D-1353-08	192847	45515222	13613761	66	17764											
ID1	3397	broad.mit.edu	37	chr20	30193855	30193855	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catttcttctcgttttcacaGgcggcatgcgttcctgcgga	10	12	3	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr20:30193855G>A	uc002wwg.1	+	2	526	c.427_splice	c.e2-1	p.A143_splice	ID1_uc002wwh.1_3'UTR|hsa-mir-3193|MI0014238_5'Flank	NM_002165	NP_002156	P41134	ID1_HUMAN	inhibitor of DNA binding 1 isoform a						angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			ovary(1)	1	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			CGTTTTCACAGGCGGCATGCG	0.652													A	30193855	A	A	30193855	5	1	248	1	0	0	0	0	0	0	1	0	7489	1014	35	3	456	3	ID1	20	30193855	Splice_Site	SNP	G	TCGA-41-3915-01A-01D-1353-08		30193855	32831665	67	17765											
C21orf63	59271	broad.mit.edu	37	chr21	33876254	33876254	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggtataaacttcgacccaaGcggatcgaaggttctgagga	12	8	1	1			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr21:33876254G>T	uc002ypr.1	+	7	1288	c.878G>T	c.(877-879)AGC>ATC	p.S293I	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Missense_Mutation_p.S290I|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Missense_Mutation_p.S198I|C21orf63_uc011adq.1_5'UTR	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	293	Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						TTCGACCCAAGCGGATCGAAG	0.433													T	33876254	T	T	33876254	3	4	248	1	0	0	0	0	1	0	0	0	2131	971	34	5	904	5	C21orf63	21	33876254	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08		33876254	14253641	68	17766			1	43		2	2	24	G		5.126377e-05
C21orf63	59271	broad.mit.edu	37	chr21	33876277	33876277	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gatcgaaggttctgaggaaaGatggaattcttgttagcaac	12	5	2	2			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chr21:33876277G>T	uc002ypr.1	+	7	1311	c.901G>T	c.(901-903)GAT>TAT	p.D301Y	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Missense_Mutation_p.D298Y|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Missense_Mutation_p.D206Y|C21orf63_uc011adq.1_5'UTR	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	301	Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						TCTGAGGAAAGATGGAATTCT	0.398													T	33876277	T	T	33876277	3	4	248	1	0	0	0	0	1	0	0	0	2131	942	33	5	927	5	C21orf63	21	33876277	Missense_Mutation	SNP	G	TCGA-41-3915-01A-01D-1353-08	23	33876277	14253618	69	17767			1	43		2	2	24	G		5.126377e-05
ATP11C	286410	broad.mit.edu	37	chrX	138867417	138867417	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tcacaattacactcatacgtCgccggacagcatcaaagttt	6	12	3	0			TCGA-41-3915-01A-01D-1353-08	TCGA-41-3915-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	83b1f0ed-3277-4bed-bfaa-a45952e6d833	dd9c946a-f5bf-4aa0-abfd-e56eb172f68e	g.chrX:138867417C>A	uc004faz.2	-	16	1742	c.1643G>T	c.(1642-1644)CGA>CTA	p.R548L	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.R548L	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	548	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					ACTCATACGTCGCCGGACAGC	0.338													A	138867417	A	A	138867417	3	1	248	1	0	0	0	0	1	0	0	0	1121	884	31	5	1878	5	ATP11C	23	138867417	Missense_Mutation	SNP	C	TCGA-41-3915-01A-01D-1353-08		138867417	16403143	70	17768											
ACTRT2	140625	broad.mit.edu	37	chr1	2938845	2938845	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcctcatgcagctgctcctgGccagcggccacaccttcccc	8	20	1	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr1:2938845G>T	uc001ajz.2	+	1	800	c.595G>T	c.(595-597)GCC>TCC	p.A199S		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	199						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GCTGCTCCTGGCCAGCGGCCA	0.617													T	2938845	T	T	2938845	3	4	249	1	0	0	0	0	1	0	0	0	219	1203	42	5	597	5	ACTRT2	1	2938845	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08		2938845	246311776	1	17769											
TPRG1L	127262	broad.mit.edu	37	chr1	3545150	3545150	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggctactccatgaccaggGgcaaaataggcttttagccg	12	10	0	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr1:3545150G>A	uc001akm.2	+	5	883	c.802G>A	c.(802-804)GGC>AGC	p.G268S	TPRG1L_uc009vlj.2_Missense_Mutation_p.G209S	NM_182752	NP_877429	Q5T0D9	TPRGL_HUMAN	tumor protein p63 regulated 1-like	268						cell junction|synaptic vesicle					0	all_cancers(77;0.0119)|all_epithelial(69;0.00481)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.41e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.83e-22)|GBM - Glioblastoma multiforme(42;4.77e-14)|Colorectal(212;1.12e-05)|COAD - Colon adenocarcinoma(227;5.61e-05)|Kidney(185;0.000351)|BRCA - Breast invasive adenocarcinoma(365;0.000688)|KIRC - Kidney renal clear cell carcinoma(229;0.00553)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.201)		CATGACCAGGGGCAAAATAGG	0.612													A	3545150	A	A	3545150	3	1	249	1	0	0	0	0	1	0	0	0	16416	1232	43	3	820	3	TPRG1L	1	3545150	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	606305	3545150	245705471	2	17770											
PCSK9	255738	broad.mit.edu	37	chr1	55523733	55523733	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcagccatgatgctgtctgCcgagccggagctcaccctgg	13	14	2	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr1:55523733C>T	uc001cyf.1	+	8	1496	c.1205C>T	c.(1204-1206)GCC>GTC	p.A402V	PCSK9_uc010oom.1_RNA	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	402	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						ATGCTGTCTGCCGAGCCGGAG	0.602													T	55523733	T	T	55523733	3	4	249	1	0	0	0	0	1	0	0	0	11606	739	26	3	1235	3	PCSK9	1	55523733	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	51978583	55523733	193726888	3	17771											
ADAM30	11085	broad.mit.edu	37	chr1	120436835	120436835	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtttcctatcacttgccGgaaaaacacaaaaaccactg	7	11	1	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr1:120436835G>A	uc001eij.2	-	1	2279	c.2125C>T	c.(2125-2127)CGG>TGG	p.R709W		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	709	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		ATCACTTGCCGGAAAAACACA	0.393													A	120436835	A	A	120436835	3	1	249	1	0	0	0	0	1	0	0	0	248	1115	39	2	251	2	ADAM30	1	120436835	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	64913102	120436835	128813786	4	17772											
PDC	5132	broad.mit.edu	37	chr1	186413476	186413476	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttcagttccttttcaattgTttctaggaattgctttccag	6	9	3	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr1:186413476T>G	uc001gsa.2	-	4	449	c.376A>C	c.(376-378)ACA>CCA	p.T126P	PDC_uc001grz.2_Missense_Mutation_p.T74P	NM_002597	NP_002588	P20941	PHOS_HUMAN	phosducin isoform a	126					G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			skin(1)	1		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)		TTTTCAATTGTTTCTAGGAAT	0.398													G	186413476	G	G	186413476	3	3	249	1	0	0	0	0	1	0	0	0	11614	1725	60	5	368	5	PDC	1	186413476	Missense_Mutation	SNP	T	TCGA-41-4097-01A-01D-1353-08	65976641	186413476	62837145	5	17773											
RYR2	6262	broad.mit.edu	37	chr1	237550598	237550598	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcacttgtcttatggcaaCggcagcttacacgtggatgc	11	11	1	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr1:237550598C>T	uc001hyl.1	+	9	714	c.594C>T	c.(592-594)AAC>AAT	p.N198N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	198	Cytoplasmic (By similarity).|MIR 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTATGGCAACGGCAGCTTAC	0.498													T	237550598	T	T	237550598	2	4	249	1	0	0	0	0	0	0	0	1	13769	535	19	1		1	RYR2	1	237550598	Silent	SNP	C	TCGA-41-4097-01A-01D-1353-08	51137122	237550598	11700023	6	17774											
APOB	338	broad.mit.edu	37	chr2	21227177	21227177	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagttccatttagaaaagtcGtcatcttcatccatatccat	4	10	3	1	rs12713501	byFrequency	TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr2:21227177G>A	uc002red.2	-	28	12179	c.12051C>T	c.(12049-12051)GAC>GAT	p.D4017D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4017					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TAGAAAAGTCGTCATCTTCAT	0.512													A	21227177	A	A	21227177	2	1	249	1	0	0	0	0	0	0	0	1	785	1136	40	1		1	APOB	2	21227177	Silent	SNP	G	TCGA-41-4097-01A-01D-1353-08		21227177	221972196	7	17775											
LCT	3938	broad.mit.edu	37	chr2	136566637	136566637	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctttgatgacggcgtgggCtatcctatatggtgcccagc	14	10	0	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr2:136566637C>T	uc002tuu.1	-	8	3291	c.3280G>A	c.(3280-3282)GCC>ACC	p.A1094T		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1094	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		ACGGCGTGGGCTATCCTATAT	0.542													T	136566637	T	T	136566637	3	4	249	1	0	0	0	0	1	0	0	0	8693	797	28	3	2543	3	LCT	2	136566637	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	115339460	136566637	106632736	8	17776											
TTN	7273	broad.mit.edu	37	chr2	179392028	179392028	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagagcttcaattttaggcGgaattcctttatggaacaat	9	6	1	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr2:179392028G>A	uc010zfg.1	-	312	100207	c.99983C>T	c.(99982-99984)CCG>CTG	p.P33328L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P27023L|TTN_uc010zfi.1_Missense_Mutation_p.P26956L|TTN_uc010zfj.1_Missense_Mutation_p.P26831L|TTN_uc002umq.2_Missense_Mutation_p.P244L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	34255							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTTTAGGCGGAATTCCTTT	0.378													A	179392028	A	A	179392028	3	1	249	1	0	0	0	0	1	0	0	0	16732	1116	39	2	292	2	TTN	2	179392028	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	42825391	179392028	63807345	9	17777											
ALPP	250	broad.mit.edu	37	chr2	233245025	233245025	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaggaatggctggcgaagCgccaggtgatgggggctggc	20	8	0	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr2:233245025C>T	uc002vsq.2	+	6	952	c.787C>T	c.(787-789)CGC>TGC	p.R263C	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	263						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GCTGGCGAAGCGCCAGGTGAT	0.667													T	233245025	T	T	233245025	3	4	249	1	0	0	0	0	1	0	0	0	548	768	27	1	809	1	ALPP	2	233245025	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	53852997	233245025	9954348	10	17778											
ALPPL2	251	broad.mit.edu	37	chr2	233273106	233273106	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaggaatggctggcgaagCaccaggtgatgggggctggt	19	7	0	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr2:233273106C>T	uc002vss.3	+	6	831	c.778C>T	c.(778-780)CAC>TAC	p.H260Y		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	260				H -> R (in Ref. 8; AAH14139).	phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GCTGGCGAAGCACCAGGTGAT	0.662													T	233273106	T	T	233273106	3	4	249	1	0	0	0	0	1	0	0	0	549	710	25	3	800	3	ALPPL2	2	233273106	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	28081	233273106	9926267	11	17779											
DHX30	22907	broad.mit.edu	37	chr3	47882649	47882649	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacccagcaggattcccacGctccactcagggactcaagg	10	15	2	1	rs138418233	by1000genomes	TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr3:47882649G>A	uc003cru.2	+	7	1075	c.649G>A	c.(649-651)GCT>ACT	p.A217T	DHX30_uc003crs.2_Missense_Mutation_p.A178T|DHX30_uc003crt.2_Missense_Mutation_p.A178T|DHX30_uc010hjr.1_Missense_Mutation_p.A245T	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	217						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GGATTCCCACGCTCCACTCAG	0.552													A	47882649	A	A	47882649	3	1	249	1	0	0	0	0	1	0	0	0	4504	1087	38	1	678	1	DHX30	3	47882649	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08		47882649	150139781	12	17780											
LAMP3	27074	broad.mit.edu	37	chr3	182872086	182872086	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttgctggacaggtttttttAtgtcctgtactgttgctgct	11	7	0	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr3:182872086A>G	uc003flh.3	-	2	367	c.143T>C	c.(142-144)ATA>ACA	p.I48T		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	48	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane		p.I48T(1)		ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			AGGTTTTTTTATGTCCTGTAC	0.428													G	182872086	G	G	182872086	3	3	249	1	0	0	0	0	1	0	0	0	8619	449	16	4	1127	4	LAMP3	3	182872086	Missense_Mutation	SNP	A	TCGA-41-4097-01A-01D-1353-08	134989437	182872086	15150344	13	17781											
UTP3	57050	broad.mit.edu	37	chr4	71555475	71555475	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttctgctgctgcctgtgctGttacagatctttctgatgat	9	10	3	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr4:71555475G>A	uc003hfo.2	+	1	1280	c.1081G>A	c.(1081-1083)GTT>ATT	p.V361I		NM_020368	NP_065101	Q9NQZ2	SAS10_HUMAN	UTP3, small subunit processome component	361					brain development|chromatin modification|gene silencing	nucleolus					0			Lung(101;0.235)			TGCCTGTGCTGTTACAGATCT	0.363													A	71555475	A	A	71555475	3	1	249	1	0	0	0	0	1	0	0	0	17098	1377	48	3	1083	3	UTP3	4	71555475	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08		71555475	119598801	14	17782											
ANKRD17	26057	broad.mit.edu	37	chr4	73951059	73951059	+	Frame_Shift_Del	DEL	C	-	-													gggtgctcctccaaggggtgCcccaggtccgtacatctgac							TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr4:73951059delC	uc003hgp.2	-	30	7183	c.7066delG	c.(7066-7068)GCAfs	p.A2356fs	ANKRD17_uc003hgo.2_Frame_Shift_Del_p.A2243fs|ANKRD17_uc003hgq.2_Frame_Shift_Del_p.A2105fs|ANKRD17_uc003hgr.2_Frame_Shift_Del_p.A2355fs	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	2356					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCAAGGGGTGCCCCAGGTCCG	0.463													-	73951059	-	-	73951059	7	5	249	1	0	1	0	1	0	0	0	0	646	739	26	0	765	0	ANKRD17	4	73951059	Frame_Shift_Del	DEL	C	TCGA-41-4097-01A-01D-1353-08	2395584	73951059	117203217	15	17783											
TRIML1	339976	broad.mit.edu	37	chr4	189068417	189068417	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccctcatctacagcttccCgcaggcttctttccaagagg	7	15	3	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr4:189068417C>T	uc003izm.1	+	6	1413	c.1298C>T	c.(1297-1299)CCG>CTG	p.P433L	TRIML1_uc003izn.1_Missense_Mutation_p.P157L	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	433	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TACAGCTTCCCGCAGGCTTCT	0.522													T	189068417	T	T	189068417	3	4	249	1	0	0	0	0	1	0	0	0	16547	652	23	2	1320	2	TRIML1	4	189068417	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	115117358	189068417	2085859	16	17784											
IL31RA	133396	broad.mit.edu	37	chr5	55210699	55210699	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgactcatctgtgttggccCaccgttcccaaccctgctga	8	15	2	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr5:55210699C>T	uc003jql.2	+	14	1826	c.1761C>T	c.(1759-1761)CCC>CCT	p.P587P	IL31RA_uc003jqm.2_Silent_p.P555P|IL31RA_uc003jqn.2_Silent_p.P587P|IL31RA_uc003jqo.2_Silent_p.P445P	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	555	Cytoplasmic (Potential).				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				TGTGTTGGCCCACCGTTCCCA	0.423													T	55210699	T	T	55210699	2	4	249	1	0	0	0	0	0	0	0	1	7691	581	21	3		3	IL31RA	5	55210699	Silent	SNP	C	TCGA-41-4097-01A-01D-1353-08		55210699	125704561	17	17785											
MAST4	375449	broad.mit.edu	37	chr5	66462447	66462447	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggcctctgcagccagcagCgacacctcttctgccaaggc	11	16	3	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr5:66462447C>T	uc003jut.1	+	28	6941	c.6873C>T	c.(6871-6873)AGC>AGT	p.S2291S	MAST4_uc003juw.2_Silent_p.S2219S|MAST4_uc003jux.2_Silent_p.S44S	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	2483						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CAGCCAGCAGCGACACCTCTT	0.652											OREG0016638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	66462447	T	T	66462447	2	4	249	1	0	0	0	0	0	0	0	1	9327	767	27	1		1	MAST4	5	66462447	Silent	SNP	C	TCGA-41-4097-01A-01D-1353-08	11251748	66462447	114452813	18	17786											
TTC37	9652	broad.mit.edu	37	chr5	94838702	94838702	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aacaatagacaaggctctctCataggctgttacatagaagt	8	8	2	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr5:94838702C>G	uc003klb.2	-	32	3493	c.3223G>C	c.(3223-3225)GAG>CAG	p.E1075Q		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1075	TPR 18.						binding			ovary(3)|pancreas(1)	4						AAGGCTCTCTCATAGGCTGTT	0.368													G	94838702	G	G	94838702	3	3	249	1	0	0	0	0	1	0	0	0	16702	835	29	5	1519	5	TTC37	5	94838702	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	28376255	94838702	86076558	19	17787											
FBN2	2201	broad.mit.edu	37	chr5	127611828	127611828	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agatgtagttgcatggtttcGgggactgggagcattcatca	14	6	2	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr5:127611828G>T	uc003kuu.2	-	59	7935	c.7496C>A	c.(7495-7497)CCG>CAG	p.P2499Q		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2499	EGF-like 42; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCATGGTTTCGGGGACTGGGA	0.433													T	127611828	T	T	127611828	3	4	249	1	0	0	0	0	1	0	0	0	5703	1116	39	5	1270	5	FBN2	5	127611828	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	32773126	127611828	53303432	20	17788											
ATP10B	23120	broad.mit.edu	37	chr5	160047790	160047790	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgcatcatctctctcatcCgagtctgtggtggccacgtt	10	12	4	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr5:160047790C>T	uc003lym.1	-	15	2827	c.1980G>A	c.(1978-1980)TCG>TCA	p.S660S	ATP10B_uc010jit.1_5'UTR|ATP10B_uc003lyn.2_Silent_p.S218S	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	660	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCTCTCATCCGAGTCTGTGG	0.572													T	160047790	T	T	160047790	2	4	249	1	0	0	0	0	0	0	0	1	1117	639	23	2		2	ATP10B	5	160047790	Silent	SNP	C	TCGA-41-4097-01A-01D-1353-08	32435962	160047790	20867470	21	17789											
NKAPL	222698	broad.mit.edu	37	chr6	28228340	28228340	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atggtgcacaaaaagacaaaAgagaaagatgacaagtaagg	11	4	0	4			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr6:28228340A>G	uc003nkt.2	+	1	1243	c.1191A>G	c.(1189-1191)AAA>AAG	p.K397K	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	397										upper_aerodigestive_tract(1)|ovary(1)	2						AAAAGACAAAAGAGAAAGATG	0.368													G	28228340	G	G	28228340	2	3	249	1	0	0	0	0	0	0	0	1	10440	69	3	4		4	NKAPL	6	28228340	Silent	SNP	A	TCGA-41-4097-01A-01D-1353-08		28228340	142886727	22	17790											
ZKSCAN3	80317	broad.mit.edu	37	chr6	28333384	28333384	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgccacaggagggaggcgGcacatctgccatgaatgtgg	15	9	1	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr6:28333384G>A	uc003nle.3	+	6	1155	c.939G>A	c.(937-939)CGG>CGA	p.R313R	ZKSCAN3_uc010jrc.2_Silent_p.R313R|ZKSCAN3_uc003nlf.3_Silent_p.R165R|uc010jrd.2_5'Flank	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	313					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GAGGGAGGCGGCACATCTGCC	0.493													A	28333384	A	A	28333384	2	1	249	1	0	0	0	0	0	0	0	1	17685	1190	42	3		3	ZKSCAN3	6	28333384	Silent	SNP	G	TCGA-41-4097-01A-01D-1353-08	105044	28333384	142781683	23	17791											
MDC1	9656	broad.mit.edu	37	chr6	30671653	30671653	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagaggcaggctcaggaatGgctgtaagggattcagctgc	17	7	2	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr6:30671653G>A	uc003nrg.3	-	10	5747	c.5307C>T	c.(5305-5307)GCC>GCT	p.A1769A	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Silent_p.A1376A	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1769	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GCTCAGGAATGGCTGTAAGGG	0.542								Other_conserved_DNA_damage_response_genes					A	30671653	A	A	30671653	2	1	249	1	0	0	0	0	0	0	0	1	9403	1335	47	3		3	MDC1	6	30671653	Silent	SNP	G	TCGA-41-4097-01A-01D-1353-08	2338269	30671653	140443414	24	17792											
AIF1	199	broad.mit.edu	37	chr6	31584614	31584614	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcctgatgtatgaggaaaaAgcgagagaaaaggaaaagcc	12	5	0	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr6:31584614A>G	uc003nuy.2	+	6	455	c.381A>G	c.(379-381)AAA>AAG	p.K127K	AIF1_uc010jsy.2_3'UTR|AIF1_uc003nva.2_Silent_p.K73K	NM_001623	NP_001614	P55008	AIF1_HUMAN	allograft inflammatory factor 1 isoform 3	127					actin filament bundle assembly|cell cycle arrest|inflammatory response|negative regulation of cell proliferation	nucleus|ruffle membrane	actin filament binding|calcium ion binding			ovary(1)	1						ATGAGGAAAAAGCGAGAGAAA	0.493													G	31584614	G	G	31584614	2	3	249	1	0	0	0	0	0	0	0	1	424	69	3	4		4	AIF1	6	31584614	Silent	SNP	A	TCGA-41-4097-01A-01D-1353-08	912961	31584614	139530453	25	17793											
C6orf70	55780	broad.mit.edu	37	chr6	170156477	170156477	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttggaaagtctacaatctcCtgctatttctcttagcttaa	5	10	3	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr6:170156477C>A	uc003qxg.1	+	4	392	c.359C>A	c.(358-360)CCT>CAT	p.P120H	C6orf70_uc011ehb.1_Translation_Start_Site|C6orf70_uc003qxh.1_Missense_Mutation_p.P120H|C6orf70_uc010kky.1_Translation_Start_Site	NM_018341	NP_060811	Q5T6L9	CF070_HUMAN	hypothetical protein LOC55780	120						integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		CTACAATCTCCTGCTATTTCT	0.348													A	170156477	A	A	170156477	3	1	249	1	0	0	0	0	1	0	0	0	2370	681	24	5	373	5	C6orf70	6	170156477	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	138571863	170156477	958590	26	17794											
IQCE	23288	broad.mit.edu	37	chr7	2613077	2613077	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtccctgggactcctgtctaCagagaaaaagaagatatgta	10	8	1	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr7:2613077C>A	uc003smo.3	+	6	604	c.420C>A	c.(418-420)TAC>TAA	p.Y140*	IQCE_uc010ksm.1_Nonsense_Mutation_p.Y140*|IQCE_uc003sml.1_Nonsense_Mutation_p.Y140*|IQCE_uc011jvy.1_Nonsense_Mutation_p.Y124*|IQCE_uc011jvz.1_Nonsense_Mutation_p.Y75*|IQCE_uc003smk.3_Nonsense_Mutation_p.Y124*|IQCE_uc003smn.3_Nonsense_Mutation_p.Y75*	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	140											0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		CTCCTGTCTACAGAGAAAAAG	0.343													A	2613077	A	A	2613077	4	1	249	1	0	0	0	0	0	1	0	0	7806	489	17	5	442	5	IQCE	7	2613077	Nonsense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08		2613077	156525586	27	17795											
MMD2	221938	broad.mit.edu	37	chr7	4947054	4947054	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacaccttggtctgcagggtGctgggcagatagaggtacct	15	9	1	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr7:4947054G>T	uc003sno.3	-	7	982	c.786C>A	c.(784-786)AGC>AGA	p.S262R	MMD2_uc003snl.1_Intron|MMD2_uc003snn.3_Missense_Mutation_p.S238R|MMD2_uc010ksq.2_3'UTR	NM_001100600	NP_001094070	Q8IY49	PAQRA_HUMAN	monocyte to macrophage	262	Extracellular (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		TCTGCAGGGTGCTGGGCAGAT	0.542													T	4947054	T	T	4947054	3	4	249	1	0	0	0	0	1	0	0	0	9644	1310	46	5	30	5	MMD2	7	4947054	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	2333977	4947054	154191609	28	17796											
MLL3	58508	broad.mit.edu	37	chr7	151945049	151945049	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aatagctggtttacccatgcCaatttttggagtgactgaga	10	7	0	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr7:151945049C>G	uc003wla.2	-	14	2689	c.2470G>C	c.(2470-2472)GGC>CGC	p.G824R		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	824					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTACCCATGCCAATTTTTGGA	0.408			N		medulloblastoma								G	151945049	G	G	151945049	3	3	249	1	0	0	0	0	1	0	0	0	9622	594	21	5	12449	5	MLL3	7	151945049	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	146997995	151945049	7193614	29	17797											
ARHGEF10	9639	broad.mit.edu	37	chr8	1871746	1871746	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaattcagttacagcttcCcgggaagcaggacaagttag	11	9	1	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr8:1871746C>T	uc003wpr.2	+	20	2550	c.2372C>T	c.(2371-2373)CCC>CTC	p.P791L	ARHGEF10_uc003wpq.1_Missense_Mutation_p.P815L|ARHGEF10_uc003wps.2_Missense_Mutation_p.P753L|ARHGEF10_uc003wpv.2_Missense_Mutation_p.P524L|ARHGEF10_uc010lre.2_Missense_Mutation_p.P471L	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	816					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TTACAGCTTCCCGGGAAGCAG	0.423													T	1871746	T	T	1871746	3	4	249	1	0	0	0	0	1	0	0	0	894	623	22	3	2446	3	ARHGEF10	8	1871746	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08		1871746	144492276	30	17798											
CSPP1	79848	broad.mit.edu	37	chr8	68024278	68024278	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aactgttggaacaaatggctGagcaacagaggaacaagaga	12	6	0	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr8:68024278G>A	uc003xxi.2	+	11	1328	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	CSPP1_uc003xxg.1_Missense_Mutation_p.E425K|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.E398K|CSPP1_uc003xxk.2_Missense_Mutation_p.E104K	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	433	Potential.					centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			ACAAATGGCTGAGCAACAGAG	0.353													A	68024278	A	A	68024278	3	1	249	1	0	0	0	0	1	0	0	0	3962	1291	45	3	1339	3	CSPP1	8	68024278	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	66152532	68024278	78339744	31	17799											
SULF1	23213	broad.mit.edu	37	chr8	70512942	70512942	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttacaaacattctacagcGcaaaaggctccagactttga	6	10	1	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr8:70512942G>A	uc010lza.1	+	9	1556	c.839G>A	c.(838-840)CGC>CAC	p.R280H	SULF1_uc003xyd.2_Missense_Mutation_p.R280H|SULF1_uc003xye.2_Missense_Mutation_p.R280H|SULF1_uc003xyf.2_Missense_Mutation_p.R280H|SULF1_uc003xyg.2_Missense_Mutation_p.R280H|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	280					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ATTCTACAGCGCAAAAGGCTC	0.433													A	70512942	A	A	70512942	3	1	249	1	0	0	0	0	1	0	0	0	15369	1087	38	1	857	1	SULF1	8	70512942	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	2488664	70512942	75851080	32	17800											
ZFHX4	79776	broad.mit.edu	37	chr8	77617628	77617628	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgtctgagtctagcaagatGtcagagagcaaagaccaaga	11	8	3	5			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr8:77617628G>A	uc003yav.2	+	2	1692	c.1305G>A	c.(1303-1305)ATG>ATA	p.M435I	ZFHX4_uc003yat.1_Missense_Mutation_p.M435I|ZFHX4_uc003yau.1_Missense_Mutation_p.M435I|ZFHX4_uc003yaw.1_Missense_Mutation_p.M435I	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	435						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTAGCAAGATGTCAGAGAGCA	0.488										HNSCC(33;0.089)			A	77617628	A	A	77617628	3	1	249	1	0	0	0	0	1	0	0	0	17632	1377	48	3	1307	3	ZFHX4	8	77617628	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	7104686	77617628	68746394	33	17801											
RGS22	26166	broad.mit.edu	37	chr8	101018320	101018320	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtggagtctaactgtcgagtTtcttccaccagctccaccta	8	13	2	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr8:101018320T>C	uc003yjb.1	-	16	2574	c.2379A>G	c.(2377-2379)GAA>GAG	p.E793E	RGS22_uc003yja.1_Silent_p.E612E|RGS22_uc003yjc.1_Silent_p.E781E|RGS22_uc011lgz.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	793					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ACTGTCGAGTTTCTTCCACCA	0.373													C	101018320	C	C	101018320	2	2	249	1	0	0	0	0	0	0	0	1	13305	1838	64	4		4	RGS22	8	101018320	Silent	SNP	T	TCGA-41-4097-01A-01D-1353-08	23400692	101018320	45345702	34	17802											
ANKS6	203286	broad.mit.edu	37	chr9	101530526	101530526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggacaagacattgtctatgCtgccacctgaggaaacacaa	10	10	1	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr9:101530526C>T	uc004ayu.2	-	11	2000	c.1979G>A	c.(1978-1980)AGC>AAC	p.S660N	ANKS6_uc004ayt.2_Missense_Mutation_p.S359N|ANKS6_uc004ayv.1_Missense_Mutation_p.S122N|ANKS6_uc004ayw.1_Missense_Mutation_p.S242N|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	660	Ser-rich.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				ATTGTCTATGCTGCCACCTGA	0.438													T	101530526	T	T	101530526	3	4	249	1	0	0	0	0	1	0	0	0	692	797	28	3	656	3	ANKS6	9	101530526	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08		101530526	39682905	35	17803											
OR13C4	138804	broad.mit.edu	37	chr9	107288582	107288582	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaatattttatagcagctttTacatctttatttctcaagct	3	7	2	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr9:107288582T>C	uc011lvn.1	-	1	909	c.909A>G	c.(907-909)GTA>GTG	p.V303V		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	303	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TAGCAGCTTTTACATCTTTAT	0.373													C	107288582	C	C	107288582	2	2	249	1	0	0	0	0	0	0	0	1	10936	1741	61	4		4	OR13C4	9	107288582	Silent	SNP	T	TCGA-41-4097-01A-01D-1353-08	5758056	107288582	33924849	36	17804											
SARDH	1757	broad.mit.edu	37	chr9	136594905	136594905	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acctgaatcccctcgatgcgCtcggtgacgacataggcatg	11	13	0	2	rs141160856	byFrequency	TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr9:136594905C>G	uc004cep.3	-	6	1031	c.897G>C	c.(895-897)GAG>GAC	p.E299D	SARDH_uc004ceo.2_Missense_Mutation_p.E299D|SARDH_uc011mdn.1_Missense_Mutation_p.E299D|SARDH_uc011mdo.1_Missense_Mutation_p.E131D	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	299					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CCTCGATGCGCTCGGTGACGA	0.488													G	136594905	G	G	136594905	3	3	249	1	0	0	0	0	1	0	0	0	13841	796	28	5	1923	5	SARDH	9	136594905	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	29306323	136594905	4618526	37	17805											
ZMIZ1	57178	broad.mit.edu	37	chr10	81066012	81066012	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatcatgcccaatgtcatggAgatgatcgcagccctgggcc	12	12	2	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr10:81066012A>C	uc001kaf.2	+	22	3151	c.2579A>C	c.(2578-2580)GAG>GCG	p.E860A	ZMIZ1_uc001kag.2_Missense_Mutation_p.E736A|ZMIZ1_uc010qlq.1_Missense_Mutation_p.E13A	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	860					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AATGTCATGGAGATGATCGCA	0.612													C	81066012	C	C	81066012	3	2	249	1	0	0	0	0	1	0	0	0	17693	304	11	5	2649	5	ZMIZ1	10	81066012	Missense_Mutation	SNP	A	TCGA-41-4097-01A-01D-1353-08		81066012	54468735	38	17806											
PTEN	5728	broad.mit.edu	37	chr10	89690814	89690814	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttcttttagttgtgctgaaaGacattatgacaccgccaaat	7	8	1	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr10:89690814G>C	uc001kfb.2	+	5	1252	c.221G>C	c.(220-222)AGA>ACA	p.R74T		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	74	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.L70fs*7(4)|p.R55fs*1(4)|p.?(2)|p.C71fs*6(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.R74I(1)|p.E73fs*25(1)|p.R74fs*25(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGTGCTGAAAGACATTATGAC	0.274		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89690814	C	C	89690814	3	2	249	1	0	0	0	0	1	0	0	0	12738	942	33	5	235	5	PTEN	10	89690814	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	8624802	89690814	45843933	39	17807											
PRLHR	2834	broad.mit.edu	37	chr10	120354176	120354176	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtgataggtgtgcacggcgGcgggcagcgccagcaccgcg	18	13	0	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr10:120354176G>A	uc001ldp.1	-	2	720	c.581C>T	c.(580-582)GCC>GTC	p.A194V		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	194	Helical; Name=4; (Potential).			A -> P (in Ref. 1; AAC50504).	female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GTGCACGGCGGCGGGCAGCGC	0.716													A	120354176	A	A	120354176	3	1	249	1	0	0	0	0	1	0	0	0	12530	1203	42	3	535	3	PRLHR	10	120354176	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	30663362	120354176	15180571	40	17808											
INPP5A	3632	broad.mit.edu	37	chr10	134523875	134523875	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgaatatccatcttttccatGatgcttccaatctggtcgcc	6	12	2	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr10:134523875G>C	uc001llp.2	+	8	810	c.562G>C	c.(562-564)GAT>CAT	p.D188H	INPP5A_uc001llo.1_Missense_Mutation_p.D188H|INPP5A_uc001llq.2_Missense_Mutation_p.D140H	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	188					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		TCTTTTCCATGATGCTTCCAA	0.488													C	134523875	C	C	134523875	3	2	249	1	0	0	0	0	1	0	0	0	7754	1290	45	5	592	5	INPP5A	10	134523875	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	14169699	134523875	1010872	41	17809											
BBOX1	8424	broad.mit.edu	37	chr11	27114719	27114719	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttatcaattcacagaatgCcaatactggggctcagagct	8	9	3	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr11:27114719C>T	uc001mre.1	+	5	707	c.339C>T	c.(337-339)TGC>TGT	p.C113C	BBOX1_uc009yih.1_Silent_p.C113C|BBOX1_uc001mrg.1_Silent_p.C113C	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	113					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	TCACAGAATGCCAATACTGGG	0.393													T	27114719	T	T	27114719	2	4	249	1	0	0	0	0	0	0	0	1	1334	747	26	3		3	BBOX1	11	27114719	Silent	SNP	C	TCGA-41-4097-01A-01D-1353-08		27114719	107891797	42	17810											
SYT13	57586	broad.mit.edu	37	chr11	45274269	45274269	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cctccgtcgtggttgctggtCacagctgcaggcaaggagaa	14	11	1	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr11:45274269C>A	uc001myq.2	-	4	675	c.549G>T	c.(547-549)GTG>GTT	p.V183V	SYT13_uc009yku.1_Silent_p.V39V	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	183	Cytoplasmic (Potential).|C2 1.					transport vesicle				ovary(1)	1						GGTTGCTGGTCACAGCTGCAG	0.587											OREG0020928	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	45274269	A	A	45274269	2	1	249	1	0	0	0	0	0	0	0	1	15466	813	29	5		5	SYT13	11	45274269	Silent	SNP	C	TCGA-41-4097-01A-01D-1353-08	18159550	45274269	89732247	43	17811											
KCTD14	65987	broad.mit.edu	37	chr11	77728030	77728030	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgctcaccaaagatctgtGgcatgtcctccagcagcttg	9	14	2	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr11:77728030G>A	uc001oyw.3	-	2	402	c.377C>T	c.(376-378)CCA>CTA	p.P126L		NM_023930	NP_076419	Q9BQ13	KCD14_HUMAN	potassium channel tetramerisation domain	126	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)			AAAGATCTGTGGCATGTCCTC	0.567													A	77728030	A	A	77728030	3	1	249	1	0	0	0	0	1	0	0	0	8101	1348	47	3	394	3	KCTD14	11	77728030	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	32453761	77728030	57278486	44	17812											
KDM4D	55693	broad.mit.edu	37	chr11	94731105	94731105	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgtggaaaaccacgtttgCttggcatacagaggacatgg	12	8	0	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr11:94731105C>T	uc001pfe.2	+	3	1401	c.569C>T	c.(568-570)GCT>GTT	p.A190V		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	190	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ACCACGTTTGCTTGGCATACA	0.512													T	94731105	T	T	94731105	3	4	249	1	0	0	0	0	1	0	0	0	8131	797	28	3	571	3	KDM4D	11	94731105	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	17003075	94731105	40275411	45	17813											
MLL	4297	broad.mit.edu	37	chr11	118359396	118359396	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaggagaacgagcgccctcTggaggaccagctggaaaatt	14	9	1	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr11:118359396T>C	uc001pta.2	+	11	4423	c.4400T>C	c.(4399-4401)CTG>CCG	p.L1467P	MLL_uc001ptb.2_Missense_Mutation_p.L1467P|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1467	PHD-type 1.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GAGCGCCCTCTGGAGGACCAG	0.433			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								C	118359396	C	C	118359396	3	2	249	1	0	0	0	0	1	0	0	0	9620	1580	55	4	4442	4	MLL	11	118359396	Missense_Mutation	SNP	T	TCGA-41-4097-01A-01D-1353-08	23628291	118359396	16647120	46	17814											
OR4D5	219875	broad.mit.edu	37	chr11	123810626	123810626	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtggatgcctgactcaactCttcttcttccacttcattgg	8	12	5	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr11:123810626C>T	uc001pzk.1	+	1	303	c.303C>T	c.(301-303)CTC>CTT	p.L101L		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	101	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TGACTCAACTCTTCTTCTTCC	0.507													T	123810626	T	T	123810626	2	4	249	1	0	0	0	0	0	0	0	1	11057	900	32	3		3	OR4D5	11	123810626	Silent	SNP	C	TCGA-41-4097-01A-01D-1353-08	5451230	123810626	11195890	47	17815											
OR10S1	219873	broad.mit.edu	37	chr11	123847863	123847863	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggcccacagtagagcaggCggaaggtgagggaggtgtgg	20	6	0	2	rs141270826		TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr11:123847863C>T	uc001pzm.1	-	1	536	c.536G>A	c.(535-537)CGC>CAC	p.R179H		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GTAGAGCAGGCGGAAGGTGAG	0.552													T	123847863	T	T	123847863	3	4	249	1	0	0	0	0	1	0	0	0	10918	768	27	1	463	1	OR10S1	11	123847863	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	37237	123847863	11158653	48	17816											
PATE2	399967	broad.mit.edu	37	chr11	125648646	125648646	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagagcagaaagactgtgCccaggagaaagagaacaagc	14	8	0	5			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr11:125648646C>T	uc001qcu.2	-	1	69	c.23G>A	c.(22-24)GGC>GAC	p.G8D	PATE2_uc010sbj.1_Missense_Mutation_p.G8D	NM_212555	NP_997720	Q6UY27	PATE2_HUMAN	prostate and testis expressed 2 precursor	8						extracellular space					0						AAAGACTGTGCCCAGGAGAAA	0.522													T	125648646	T	T	125648646	3	4	249	1	0	0	0	0	1	0	0	0	11474	739	26	3	334	3	PATE2	11	125648646	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	1800783	125648646	9357870	49	17817											
ANO2	57101	broad.mit.edu	37	chr12	5687643	5687643	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	ggcaaacacaggtgccagggGaaaggaggccacgaagaggg	18	8	0	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr12:5687643G>C	uc001qnm.2	-	22	2347	c.2275C>G	c.(2275-2277)CCC>GCC	p.P759A		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	764	Helical; (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						GGTGCCAGGGGAAAGGAGGCC	0.537													C	5687643	C	C	5687643	3	2	249	1	0	0	0	0	1	0	0	0	697	1174	41	5	741	5	ANO2	12	5687643	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08		5687643	128164252	50	17818											
MLL2	8085	broad.mit.edu	37	chr12	49432573	49432573	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tggcagacgggtggaaattcCcgccaacggggaacctaggg	16	10	0	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr12:49432573C>G	uc001rta.3	-	34	8566	c.8566G>C	c.(8566-8568)GGA>CGA	p.G2856R		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2856					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTGGAAATTCCCGCCAACGGG	0.557			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			G	49432573	G	G	49432573	3	3	249	1	0	0	0	0	1	0	0	0	9621	632	22	5	8131	5	MLL2	12	49432573	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	43744930	49432573	84419322	51	17819											
CALCOCO1	57658	broad.mit.edu	37	chr12	54105903	54105903	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acagggtacccactgtaaagCcactaagagagacagagggg	13	9	0	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr12:54105903C>G	uc001sef.2	-	15	2045	c.1901G>C	c.(1900-1902)GGC>GCC	p.G634A	CALCOCO1_uc001see.2_Missense_Mutation_p.G159A|CALCOCO1_uc010som.1_Missense_Mutation_p.G549A|CALCOCO1_uc010son.1_Missense_Mutation_p.G511A|CALCOCO1_uc001seh.2_3'UTR|CALCOCO1_uc009znd.2_Missense_Mutation_p.G633A|CALCOCO1_uc001seg.2_Missense_Mutation_p.G459A	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	634	C-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CACTGTAAAGCCACTAAGAGA	0.577													G	54105903	G	G	54105903	3	3	249	1	0	0	0	0	1	0	0	0	2577	739	26	5	178	5	CALCOCO1	12	54105903	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	4673330	54105903	79745992	52	17820											
SUOX	6821	broad.mit.edu	37	chr12	56398139	56398139	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtctgctttgagggactggaCtcagaccctactgggactgc	13	11	2	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr12:56398139C>G	uc001six.2	+	6	1292	c.966C>G	c.(964-966)GAC>GAG	p.D322E	SUOX_uc001siy.2_Missense_Mutation_p.D322E|SUOX_uc001siz.2_Missense_Mutation_p.D322E|SUOX_uc001sja.2_Missense_Mutation_p.D322E	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	322	Molybdenum-pterin domain (By similarity).|Molybdenum-pterin-binding (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			AGGGACTGGACTCAGACCCTA	0.607													G	56398139	G	G	56398139	3	3	249	1	0	0	0	0	1	0	0	0	15392	564	20	5	976	5	SUOX	12	56398139	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	2292236	56398139	77453756	53	17821											
LRRIQ1	84125	broad.mit.edu	37	chr12	85450952	85450952	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tcgatgtggcccttgggataCtttacagcaggtatttctaa	10	8	1	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr12:85450952C>G	uc001tac.2	+	8	2492	c.2381C>G	c.(2380-2382)ACT>AGT	p.T794S	LRRIQ1_uc001tab.1_Missense_Mutation_p.T794S|LRRIQ1_uc001taa.1_Missense_Mutation_p.T769S	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	794										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		CCTTGGGATACTTTACAGCAG	0.313													G	85450952	G	G	85450952	3	3	249	1	0	0	0	0	1	0	0	0	9029	565	20	5	2407	5	LRRIQ1	12	85450952	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	29052813	85450952	48400943	54	17822											
ISCU	23479	broad.mit.edu	37	chr12	108962628	108962628	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctggctgaagatgcaatcaAggccgccctggctgattaca	12	11	1	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr12:108962628A>G	uc010sxc.1	+	5	545	c.440A>G	c.(439-441)AAG>AGG	p.K147R	ISCU_uc010sxb.1_3'UTR|ISCU_uc001tnc.3_Missense_Mutation_p.K122R|ISCU_uc009zuy.2_3'UTR|ISCU_uc010sxd.1_3'UTR	NM_213595	NP_998760	Q9H1K1	ISCU_HUMAN	iron-sulfur cluster assembly enzyme isoform	147					iron-sulfur cluster assembly|nitrogen fixation	cytosol|mitochondrion|nucleus	iron ion binding|iron-sulfur cluster binding|protein complex scaffold				0						GATGCAATCAAGGCCGCCCTG	0.478													G	108962628	G	G	108962628	3	3	249	1	0	0	0	0	1	0	0	0	7852	72	3	4	383	4	ISCU	12	108962628	Missense_Mutation	SNP	A	TCGA-41-4097-01A-01D-1353-08	23511676	108962628	24889267	55	17823											
HNF1A	6927	broad.mit.edu	37	chr12	121426701	121426701	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcagcacaacatcccacagcGggaggtggtcgataccactg	12	13	0	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr12:121426701G>T	uc001tzg.2	+	2	415	c.392G>T	c.(391-393)CGG>CTG	p.R131L	HNF1A_uc001tze.1_Missense_Mutation_p.R131L|HNF1A_uc001tzf.2_Missense_Mutation_p.R131L|HNF1A_uc010szn.1_Missense_Mutation_p.R131L	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	131	Interaction with DNA.		R -> Q (in MODY3; expected to interfere with DNA binding).|R -> W (in MODY3; expected to interfere with DNA binding).		glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding	p.R131W(1)		liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATCCCACAGCGGGAGGTGGTC	0.622									Hepatic_Adenoma_Familial_Clustering_of				T	121426701	T	T	121426701	3	4	249	1	0	0	0	0	1	0	0	0	7251	1116	39	5	398	5	HNF1A	12	121426701	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	12464073	121426701	12425194	56	17824											
GOLGA3	2802	broad.mit.edu	37	chr12	133383767	133383767	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgaacgtccgttacctgaCtcgcctccagtgacaaggct	10	14	0	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr12:133383767C>T	uc001ukz.1	-	6	1845	c.1286G>A	c.(1285-1287)AGT>AAT	p.S429N	GOLGA3_uc001ula.1_Missense_Mutation_p.S429N|GOLGA3_uc001ulb.2_Missense_Mutation_p.S429N	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	429	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CGTTACCTGACTCGCCTCCAG	0.547													T	133383767	T	T	133383767	3	4	249	1	0	0	0	0	1	0	0	0	6554	565	20	3	3424	3	GOLGA3	12	133383767	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	11957066	133383767	468128	57	17825											
GSX1	219409	broad.mit.edu	37	chr13	28367747	28367747	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcaagaggatgcgcacgGctttcaccagcacgcagctg	13	13	1	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr13:28367747G>A	uc001urr.1	+	2	505	c.457G>A	c.(457-459)GCT>ACT	p.A153T		NM_145657	NP_663632	Q9H4S2	GSX1_HUMAN	GS homeobox 1	153	Homeobox.				positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		GATGCGCACGGCTTTCACCAG	0.577													A	28367747	A	A	28367747	3	1	249	1	0	0	0	0	1	0	0	0	6849	1203	42	3	463	3	GSX1	13	28367747	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08		28367747	86802131	58	17826											
NBEA	26960	broad.mit.edu	37	chr13	35883701	35883701	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttcagaagaatgcaggacttGcatttattgagctcatcaat	8	7	3	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr13:35883701G>C	uc001uvb.2	+	36	6081	c.5875G>C	c.(5875-5877)GCA>CCA	p.A1959P	NBEA_uc010abi.2_Missense_Mutation_p.A615P	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1959						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGCAGGACTTGCATTTATTGA	0.343													C	35883701	C	C	35883701	3	2	249	1	0	0	0	0	1	0	0	0	10187	1319	46	5	6017	5	NBEA	13	35883701	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	7515954	35883701	79286177	59	17827											
RNF31	55072	broad.mit.edu	37	chr14	24620756	24620756	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tctctccaggcattgttccaGcacggaggtgatgtgtcacg	12	11	2	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr14:24620756G>C	uc001wmn.1	+	10	2049	c.1800G>C	c.(1798-1800)CAG>CAC	p.Q600H	RNF31_uc001wml.1_Missense_Mutation_p.Q449H|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.Q359H|RNF31_uc001wmo.1_Missense_Mutation_p.Q67H|RNF31_uc001wmp.2_RNA	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	600	Interaction with RBCK1.|UBA.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		CATTGTTCCAGCACGGAGGTG	0.627													C	24620756	C	C	24620756	3	2	249	1	0	0	0	0	1	0	0	0	13487	962	34	5	1838	5	RNF31	14	24620756	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08		24620756	82728784	60	17828											
GPR65	8477	broad.mit.edu	37	chr14	88477519	88477519	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattcctcacctgcattgccGttgatcggtatttggctgtt	9	11	1	1	rs142375010	byFrequency	TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr14:88477519G>A	uc001xvv.2	+	2	858	c.328G>A	c.(328-330)GTT>ATT	p.V110I		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	110	Helical; Name=3; (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						CTGCATTGCCGTTGATCGGTA	0.433													A	88477519	A	A	88477519	3	1	249	1	0	0	0	0	1	0	0	0	6706	1145	40	1	330	1	GPR65	14	88477519	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	63856763	88477519	18872021	61	17829											
AHNAK2	113146	broad.mit.edu	37	chr14	105405535	105405535	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaagggctgtatcaatattgGcctctggacactgcacttcc	9	11	2	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr14:105405535G>A	uc010axc.1	-	7	16373	c.16253C>T	c.(16252-16254)GCC>GTC	p.A5418V	AHNAK2_uc001ypx.2_Missense_Mutation_p.A5318V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5418						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATCAATATTGGCCTCTGGACA	0.557													A	105405535	A	A	105405535	3	1	249	1	0	0	0	0	1	0	0	0	415	1203	42	3	1138	3	AHNAK2	14	105405535	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	16928016	105405535	1944005	62	17830											
SECISBP2L	9728	broad.mit.edu	37	chr15	49284790	49284790	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcttcttcttcaagcatgCcaggtacaagagtgctggtg	10	10	4	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr15:49284790C>T	uc001zxe.1	-	18	3091	c.2957G>A	c.(2956-2958)GGC>GAC	p.G986D	SECISBP2L_uc001zxd.1_Missense_Mutation_p.G941D	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	986										breast(1)|skin(1)	2						ttcAAGCATGCCAGGTACAAG	0.383													T	49284790	T	T	49284790	3	4	249	1	0	0	0	0	1	0	0	0	14007	739	26	3	352	3	SECISBP2L	15	49284790	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08		49284790	53246602	63	17831											
SLC27A2	11001	broad.mit.edu	37	chr15	50497504	50497504	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgactgcagaaaatacaacGtcactgtcattcagtatatc	6	9	3	2	rs141444028		TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr15:50497504G>A	uc001zxw.2	+	4	1148	c.916G>A	c.(916-918)GTC>ATC	p.V306I	SLC27A2_uc010bes.2_Missense_Mutation_p.V253I|SLC27A2_uc001zxx.2_Missense_Mutation_p.V71I	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	306	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		AAAATACAACGTCACTGTCAT	0.428													A	50497504	A	A	50497504	3	1	249	1	0	0	0	0	1	0	0	0	14526	1145	40	1	930	1	SLC27A2	15	50497504	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	1212714	50497504	52033888	64	17832											
C15orf39	56905	broad.mit.edu	37	chr15	75501019	75501019	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtggagctgcggcccaccaCgctgtcggaggagcgggcac	17	13	0	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr15:75501019C>T	uc002azp.3	+	2	2950	c.2630C>T	c.(2629-2631)ACG>ATG	p.T877M	C15orf39_uc002azq.3_Missense_Mutation_p.T877M|C15orf39_uc002azr.3_Missense_Mutation_p.T275M	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	877											0						CGGCCCACCACGCTGTCGGAG	0.667													T	75501019	T	T	75501019	3	4	249	1	0	0	0	0	1	0	0	0	1793	536	19	1	2632	1	C15orf39	15	75501019	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	25003515	75501019	27030373	65	17833											
C15orf27	123591	broad.mit.edu	37	chr15	76484332	76484332	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagatccggcagctgcgcgcGcacctggcgcagcaggacct	15	15	0	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr15:76484332G>A	uc002bbq.2	+	9	947	c.792G>A	c.(790-792)GCG>GCA	p.A264A	C15orf27_uc010bkp.2_Silent_p.A80A|C15orf27_uc002bbr.2_Silent_p.A80A|C15orf27_uc002bbs.2_5'UTR	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	264	Potential.					integral to membrane					0						AGCTGCGCGCGCACCTGGCGC	0.716													A	76484332	A	A	76484332	2	1	249	1	0	0	0	0	0	0	0	1	1788	1074	38	1		1	C15orf27	15	76484332	Silent	SNP	G	TCGA-41-4097-01A-01D-1353-08	983313	76484332	26047060	66	17834											
ZNF668	79759	broad.mit.edu	37	chr16	31072650	31072650	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgggtgtgagcgctcgtgCcgacgcagcagcgtcattgt	15	12	1	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr16:31072650C>T	uc010caf.2	-	3	1956	c.1599G>A	c.(1597-1599)CGG>CGA	p.R533R	ZNF668_uc002eao.2_Silent_p.R533R	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	533	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						AGCGCTCGTGCCGACGCAGCA	0.672													T	31072650	T	T	31072650	2	4	249	1	0	0	0	0	0	0	0	1	18072	726	26	3		3	ZNF668	16	31072650	Silent	SNP	C	TCGA-41-4097-01A-01D-1353-08		31072650	59282103	67	17835											
CPNE7	27132	broad.mit.edu	37	chr16	89655119	89655119	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgcctccaatggagacccgCggaacagctgctccctgcac	10	18	0	1	rs145109453		TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr16:89655119C>T	uc002fnp.2	+	12	1319	c.1189C>T	c.(1189-1191)CGG>TGG	p.R397W	CPNE7_uc002fnq.2_Missense_Mutation_p.R322W	NM_014427	NP_055242	Q9UBL6	CPNE7_HUMAN	copine 7 isoform b	397	VWFA.				lipid metabolic process		transporter activity				0		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		TGGAGACCCGCGGAACAGCTG	0.647													T	89655119	T	T	89655119	3	4	249	1	0	0	0	0	1	0	0	0	3817	759	27	1	1235	1	CPNE7	16	89655119	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	58582469	89655119	699634	68	17836											
NF1	4763	broad.mit.edu	37	chr17	29508778	29508778	+	Nonsense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gatgaatttacaaaactgtaCcagatcccacagactgatat	6	9	0	4			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr17:29508778C>G	uc002hgg.2	+	7	1038	c.705C>G	c.(703-705)TAC>TAG	p.Y235*	NF1_uc002hge.1_Nonsense_Mutation_p.Y235*|NF1_uc002hgf.1_Nonsense_Mutation_p.Y235*|NF1_uc002hgh.2_Nonsense_Mutation_p.Y235*|NF1_uc010csn.1_Nonsense_Mutation_p.Y95*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	235					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CAAAACTGTACCAGATCCCAC	0.313			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			G	29508778	G	G	29508778	4	3	249	1	0	0	0	0	0	1	0	0	10356	518	18	5	731	5	NF1	17	29508778	Nonsense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08		29508778	51686432	69	17837											
SLC4A1	6521	broad.mit.edu	37	chr17	42330723	42330723	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cttgaccatcttgcgctcagGtttgctgacaatcagcctac	8	13	3	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr17:42330723G>C	uc002igf.3	-	17	2223	c.2074C>G	c.(2074-2076)CCT>GCT	p.P692A		NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	692	Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TTGCGCTCAGGTTTGCTGACA	0.612													C	42330723	C	C	42330723	3	2	249	1	0	0	0	0	1	0	0	0	14650	1261	44	5	677	5	SLC4A1	17	42330723	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	12821945	42330723	38864487	70	17838											
CNDP2	55748	broad.mit.edu	37	chr18	72167228	72167228	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatggcggccctcactacccTgtttaagtacatagatgaaa	9	10	1	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr18:72167228T>C	uc002llm.1	+	2	182	c.20T>C	c.(19-21)CTG>CCG	p.L7P	CNDP2_uc002lln.1_Missense_Mutation_p.L7P|CNDP2_uc002llo.2_Missense_Mutation_p.L7P	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	7						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		CTCACTACCCTGTTTAAGTAC	0.458													C	72167228	C	C	72167228	3	2	249	1	0	0	0	0	1	0	0	0	3594	1580	55	4	22	4	CNDP2	18	72167228	Missense_Mutation	SNP	T	TCGA-41-4097-01A-01D-1353-08		72167228	5910020	71	17839											
ITPKC	80271	broad.mit.edu	37	chr19	41245286	41245286	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	taggcagctccctcctcttcGtgcacgaccacaccggcctg	9	18	1	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr19:41245286G>C	uc002oot.2	+	7	1906	c.1873G>C	c.(1873-1875)GTG>CTG	p.V625L		NM_025194	NP_079470	Q96DU7	IP3KC_HUMAN	inositol 1,4,5-trisphosphate 3-kinase C	625						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CCTCCTCTTCGTGCACGACCA	0.617													C	41245286	C	C	41245286	3	2	249	1	0	0	0	0	1	0	0	0	7919	1145	40	5	1899	5	ITPKC	19	41245286	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08		41245286	17883697	72	17840											
SIGLEC5	8778	broad.mit.edu	37	chr19	52132644	52132644	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctggacagttctctccgtggTcacctgagctccttggcgtt	11	13	2	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr19:52132644T>A	uc002pxe.2	-	3	806	c.667A>T	c.(667-669)ACC>TCC	p.T223S		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	223	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CTCTCCGTGGTCACCTGAGCT	0.582													A	52132644	A	A	52132644	3	1	249	1	0	0	0	0	1	0	0	0	14311	1667	58	5	1016	5	SIGLEC5	19	52132644	Missense_Mutation	SNP	T	TCGA-41-4097-01A-01D-1353-08	10887358	52132644	6996339	73	17841											
LILRA6	79168	broad.mit.edu	37	chr19	54744985	54744985	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	ggccctgcagggtcaggaggGagggcttcctagacacgcct	16	12	1	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr19:54744985G>T	uc002qeu.1	-	5	801	c.677C>A	c.(676-678)TCC>TAC	p.S226Y	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Missense_Mutation_p.S226Y|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.S226Y|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.S226Y|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.S226Y|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Missense_Mutation_p.S226Y|LILRA6_uc010yeq.1_Missense_Mutation_p.S226Y|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.S87Y	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	226	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGTCAGGAGGGAGGGCTTCCT	0.632													T	54744985	T	T	54744985	3	4	249	1	0	0	0	0	1	0	0	0	8789	1174	41	5	784	5	LILRA6	19	54744985	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	2612341	54744985	4383998	74	17842											
ZNF460	10794	broad.mit.edu	37	chr19	57802944	57802944	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cttgagtgtgggaaggccttCaactgcaggtcacacctcaa	11	11	3	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr19:57802944C>G	uc002qog.2	+	3	1357	c.1035C>G	c.(1033-1035)TTC>TTG	p.F345L	ZNF460_uc010ygv.1_Missense_Mutation_p.F304L	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	345	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGAAGGCCTTCAACTGCAGGT	0.488													G	57802944	G	G	57802944	3	3	249	1	0	0	0	0	1	0	0	0	17921	825	29	5	1045	5	ZNF460	19	57802944	Missense_Mutation	SNP	C	TCGA-41-4097-01A-01D-1353-08	3057959	57802944	1326039	75	17843											
SCAND1	51282	broad.mit.edu	37	chr20	34542061	34542061	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cggcgttgggactggaaggcTcaggggcaggcggtgaggcc	21	9	1	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr20:34542061T>C	uc002xen.1	-	2	260	c.146A>G	c.(145-147)GAG>GGG	p.E49G	SCAND1_uc002xeo.2_Missense_Mutation_p.E49G|SCAND1_uc002xep.2_Missense_Mutation_p.E49G	NM_033630	NP_361012	P57086	SCND1_HUMAN	SCAN domain containing protein 1	49					viral reproduction	nucleus	identical protein binding|sequence-specific DNA binding transcription factor activity				0	Breast(12;0.00631)|all_lung(11;0.0233)					ACTGGAAGGCTCAGGGGCAGG	0.711													C	34542061	C	C	34542061	3	2	249	1	0	0	0	0	1	0	0	0	13875	1551	54	4	397	4	SCAND1	20	34542061	Missense_Mutation	SNP	T	TCGA-41-4097-01A-01D-1353-08		34542061	28483459	76	17844											
DLGAP4	22839	broad.mit.edu	37	chr20	35060225	35060225	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcaacccctacctgctgtcGcccacggaggccttcgcccg	10	20	0	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr20:35060225G>A	uc002xff.2	+	3	540	c.105G>A	c.(103-105)TCG>TCA	p.S35S	DLGAP4_uc010zvp.1_Silent_p.S35S	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	35					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				ACCTGCTGTCGCCCACGGAGG	0.701													A	35060225	A	A	35060225	2	1	249	1	0	0	0	0	0	0	0	1	4562	1074	38	1		1	DLGAP4	20	35060225	Silent	SNP	G	TCGA-41-4097-01A-01D-1353-08	518164	35060225	27965295	77	17845											
SHANK3	85358	broad.mit.edu	37	chr22	51160153	51160153	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgtccagcgatgaggagaccAgggaggagctggcccgaatt	16	10	0	2			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chr22:51160153A>G	uc003bne.1	+	22	3940	c.3940A>G	c.(3940-3942)AGG>GGG	p.R1314G	SHANK3_uc003bnf.1_Missense_Mutation_p.R761G|SHANK3_uc010hbg.1_Missense_Mutation_p.R496G	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1314										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		TGAGGAGACCAGGGAGGAGCT	0.677													G	51160153	G	G	51160153	3	3	249	1	0	0	0	0	1	0	0	0	14266	179	7	4	4026	4	SHANK3	22	51160153	Missense_Mutation	SNP	A	TCGA-41-4097-01A-01D-1353-08		51160153	144413	78	17846											
APOO	79135	broad.mit.edu	37	chrX	23899048	23899048	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcaagctcaggctggctgGccccacggacctctgaatta	12	13	2	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chrX:23899048G>A	uc004dax.2	-	2	262	c.31C>T	c.(31-33)CCA>TCA	p.P11S	APOO_uc004daw.2_RNA|APOO_uc004day.3_RNA	NM_024122	NP_077027	Q9BUR5	APOO_HUMAN	apolipoprotein O precursor	11					lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle					0						AGGCTGGCTGGCCCCACGGAC	0.458													A	23899048	A	A	23899048	3	1	249	1	0	0	0	0	1	0	0	0	813	1203	42	3	593	3	APOO	23	23899048	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08		23899048	131371512	79	17847											
MAGEB3	4114	broad.mit.edu	37	chrX	30254384	30254384	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagaccctctaatcatgaagAcaaatatgttggtgcagttc	8	9	2	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chrX:30254384A>G	uc004dca.1	+	5	1080	c.343A>G	c.(343-345)ACA>GCA	p.T115A		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	115	MAGE.										0						AATCATGAAGACAAATATGTT	0.403													G	30254384	G	G	30254384	3	3	249	1	0	0	0	0	1	0	0	0	9177	275	10	4	345	4	MAGEB3	23	30254384	Missense_Mutation	SNP	A	TCGA-41-4097-01A-01D-1353-08	6355336	30254384	125016176	80	17848											
CXorf65	158830	broad.mit.edu	37	chrX	70324148	70324148	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacatttggcaagtcttacCgggacactcgcagggggttc	12	11	2	0			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chrX:70324148C>T	uc011mpo.1	-	5	440	c.426G>A	c.(424-426)CCG>CCA	p.P142P	CXorf65_uc011mpp.1_Silent_p.P94P	NM_001025265	NP_001020436	A6NEN9	CX065_HUMAN	hypothetical protein LOC158830	142										central_nervous_system(1)	1						CAAGTCTTACCGGGACACTCG	0.517													T	70324148	T	T	70324148	2	4	249	1	0	0	0	0	0	0	0	1	4117	666	23	2		2	CXorf65	23	70324148	Silent	SNP	C	TCGA-41-4097-01A-01D-1353-08	40069764	70324148	84946412	81	17849											
STAG2	10735	broad.mit.edu	37	chrX	123182854	123182854	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaatgatgtgtttttttacaGcttcaggaaaatcaagatga	8	4	2	3			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chrX:123182854G>T	uc004etz.3	+	9	1159	c.820_splice	c.e9-1	p.L274_splice	STAG2_uc004eua.2_Splice_Site_p.L274_splice|STAG2_uc004eub.2_Splice_Site_p.L274_splice|STAG2_uc004euc.2_Splice_Site_p.L274_splice|STAG2_uc004eud.2_Splice_Site_p.L274_splice|STAG2_uc004eue.2_Splice_Site_p.L274_splice	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b						cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TTTTTTTACAGCTTCAGGAAA	0.308													T	123182854	T	T	123182854	5	4	249	1	0	0	0	0	0	0	1	0	15242	985	34	5	849	5	STAG2	23	123182854	Splice_Site	SNP	G	TCGA-41-4097-01A-01D-1353-08	52858706	123182854	32087706	82	17850											
BRCC3	79184	broad.mit.edu	37	chrX	154344437	154344437	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aagatcctgtgccaggaggaGcaggatgcgtataggaggat	16	6	0	1			TCGA-41-4097-01A-01D-1353-08	TCGA-41-4097-10A-01D-1353-08									Somatic	Phase_I	Capture				Illumina GAIIx	1f6b6d1e-c6b0-4f46-a792-cdd0f755033c	fadac2f2-f59d-4e7e-a349-c65d02e9ae72	g.chrX:154344437G>C	uc004fna.2	+	9	822	c.729G>C	c.(727-729)GAG>GAC	p.E243D	BRCC3_uc004fnb.2_Missense_Mutation_p.E218D	NM_024332	NP_077308	P46736	BRCC3_HUMAN	BRCA1/BRCA2-containing complex, subunit 3	243					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|positive regulation of DNA repair|response to X-ray	BRCA1-A complex|BRISC complex|nuclear ubiquitin ligase complex	enzyme regulator activity|metal ion binding|metallopeptidase activity|polyubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(3)|ovary(1)|large_intestine(1)|breast(1)	6	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCCAGGAGGAGCAGGATGCGT	0.333													C	154344437	C	C	154344437	3	2	249	1	0	0	0	0	1	0	0	0	1500	962	34	5	763	5	BRCC3	23	154344437	Missense_Mutation	SNP	G	TCGA-41-4097-01A-01D-1353-08	31161583	154344437	926123	83	17851											
ZNF642	339559	broad.mit.edu	37	chr1	40945132	40945132	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagggggcgcccctgtgggaGgatgtgactaaaatgtttga	17	6	0	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr1:40945132G>A	uc001cfo.2	+	2	393	c.99G>A	c.(97-99)GAG>GAA	p.E33E	ZNF642_uc009vwb.2_Silent_p.E33E|ZNF642_uc010ojk.1_Silent_p.E33E	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642	33	SCAN box.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)			CCCTGTGGGAGGATGTGACTA	0.532													A	40945132	A	A	40945132	2	1	250	1	0	0	0	0	0	0	0	1	18055	991	35	3		3	ZNF642	1	40945132	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08		40945132	208305489	1	17852											
FLG	2312	broad.mit.edu	37	chr1	152275826	152275826	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccgctgattcaccctggcCggactgtgagtgtctagagc	12	14	2	3	rs143233744		TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr1:152275826C>T	uc001ezu.1	-	3	11572	c.11536G>A	c.(11536-11538)GGC>AGC	p.G3846S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3846	Filaggrin 23.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCACCCTGGCCGGACTGTGAG	0.592									Ichthyosis				T	152275826	T	T	152275826	3	4	250	1	0	0	0	0	1	0	0	0	5922	652	23	2	653	2	FLG	1	152275826	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	111330694	152275826	96974795	2	17853											
FLG	2312	broad.mit.edu	37	chr1	152275878	152275878	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggaagcttcatggtgacgCgaccctgagtgcctggagcc	15	11	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr1:152275878C>T	uc001ezu.1	-	3	11520	c.11484G>A	c.(11482-11484)TCG>TCA	p.S3828S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3828	Filaggrin 23.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGTGACGCGACCCTGAGT	0.587									Ichthyosis				T	152275878	T	T	152275878	2	4	250	1	0	0	0	0	0	0	0	1	5922	755	27	1		1	FLG	1	152275878	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	52	152275878	96974743	3	17854											
SPTA1	6708	broad.mit.edu	37	chr1	158627401	158627401	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcttcaagatcattttgtcGcctagcagctcgagcacgga	11	11	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr1:158627401G>A	uc001fst.1	-	19	2870	c.2671C>T	c.(2671-2673)CGA>TGA	p.R891*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	891	Spectrin 9.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCATTTTGTCGCCTAGCAGCT	0.463													A	158627401	A	A	158627401	4	1	250	1	0	0	0	0	0	1	0	0	15115	1095	38	1	4724	1	SPTA1	1	158627401	Nonsense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	6351523	158627401	90623220	4	17855											
SPTA1	6708	broad.mit.edu	37	chr1	158637763	158637763	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atcatctcttggccagttttCtgtatgttttccagctgggt	9	9	3	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr1:158637763C>G	uc001fst.1	-	15	2122	c.1923G>C	c.(1921-1923)CAG>CAC	p.Q641H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	641	Spectrin 7.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GGCCAGTTTTCTGTATGTTTT	0.473													G	158637763	G	G	158637763	3	3	250	1	0	0	0	0	1	0	0	0	15115	912	32	5	5488	5	SPTA1	1	158637763	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	10362	158637763	90612858	5	17856											
C2orf65	130951	broad.mit.edu	37	chr2	74842218	74842218	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atctgaaacacccttctctcTgtaacatgcggagttctgag	8	11	4	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr2:74842218T>C	uc002smy.2	-	3	416	c.299A>G	c.(298-300)CAG>CGG	p.Q100R	C2orf65_uc010ysa.1_Missense_Mutation_p.Q100R|C2orf65_uc002smz.2_Missense_Mutation_p.Q100R	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	100					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						CCCTTCTCTCTGTAACATGCG	0.483													C	74842218	C	C	74842218	3	2	250	1	0	0	0	0	1	0	0	0	2184	1580	55	4	1329	4	C2orf65	2	74842218	Missense_Mutation	SNP	T	TCGA-41-5651-01A-01D-1696-08		74842218	168357155	6	17857											
IL18RAP	8807	broad.mit.edu	37	chr2	103039783	103039783	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggcttgttgcaggagagCgaattaaaggatttaatatt	11	3	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr2:103039783C>T	uc002tbx.2	+	3	530	c.46C>T	c.(46-48)CGA>TGA	p.R16*	IL18RAP_uc010fiz.2_5'UTR	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	16					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						TGCAGGAGAGCGAATTAAAGG	0.408													T	103039783	T	T	103039783	4	4	250	1	0	0	0	0	0	1	0	0	7648	760	27	1	48	1	IL18RAP	2	103039783	Nonsense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	28197565	103039783	140159590	7	17858											
ACOXL	55289	broad.mit.edu	37	chr2	111850527	111850527	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgactcccatggccagcaCgaggatcaggaatcaggtaa	11	11	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr2:111850527C>T	uc002tgr.3	+	18	1840	c.1616C>T	c.(1615-1617)ACG>ATG	p.T539M	ACOXL_uc010fkc.2_Missense_Mutation_p.T509M|ACOXL_uc010yxk.1_Missense_Mutation_p.T509M	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	539					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						ATGGCCAGCACGAGGATCAGG	0.483													T	111850527	T	T	111850527	3	4	250	1	0	0	0	0	1	0	0	0	161	536	19	1	1588	1	ACOXL	2	111850527	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	8810744	111850527	131348846	8	17859											
ABCA12	26154	broad.mit.edu	37	chr2	215855594	215855594	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataaccgagaagctgtagtcCgaaaaatacaggaacaaaat	8	7	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr2:215855594C>T	uc002vew.2	-	24	3676	c.3456G>A	c.(3454-3456)TCG>TCA	p.S1152S	ABCA12_uc002vev.2_Silent_p.S834S|ABCA12_uc010zjn.1_Silent_p.S79S	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1152	Helical; (Potential).				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGCTGTAGTCCGAAAAATACA	0.388													T	215855594	T	T	215855594	2	4	250	1	0	0	0	0	0	0	0	1	30	639	23	2		2	ABCA12	2	215855594	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	104005067	215855594	27343779	9	17860											
GLB1L	79411	broad.mit.edu	37	chr2	220108249	220108249	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcagcagtagcgtcaggctgAgcggcagcagcagggaacga	17	10	1	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr2:220108249A>T	uc002vkm.2	-	2	286	c.47T>A	c.(46-48)CTC>CAC	p.L16H	GLB1L_uc010zkx.1_Missense_Mutation_p.L16H|GLB1L_uc002vkn.2_Missense_Mutation_p.L16H|STK16_uc002vko.2_5'Flank|STK16_uc002vks.2_5'Flank|STK16_uc010zky.1_5'Flank|STK16_uc010fwf.2_5'Flank|STK16_uc002vkp.2_5'Flank|STK16_uc002vkr.2_5'Flank|STK16_uc002vkq.2_5'Flank	NM_024506	NP_078782	Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like precursor	16					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds				0		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGTCAGGCTGAGCGGCAGCAG	0.612													T	220108249	T	T	220108249	3	4	250	1	0	0	0	0	1	0	0	0	6428	304	11	5	1981	5	GLB1L	2	220108249	Missense_Mutation	SNP	A	TCGA-41-5651-01A-01D-1696-08	4252655	220108249	23091124	10	17861											
ACSL3	2181	broad.mit.edu	37	chr2	223781199	223781199	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tagctgcacaggcgtgttttAtgtataattttcagcgtatg	10	6	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr2:223781199A>G	uc002vni.2	+	5	992	c.541A>G	c.(541-543)ATG>GTG	p.M181V	ACSL3_uc002vnj.2_Missense_Mutation_p.M181V	NM_004457	NP_004448	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	181	Cytoplasmic (Potential).				long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			ovary(2)	2		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	GGCGTGTTTTATGTATAATTT	0.383			T	ETV1	prostate								G	223781199	G	G	223781199	3	3	250	1	0	0	0	0	1	0	0	0	178	449	16	4	547	4	ACSL3	2	223781199	Missense_Mutation	SNP	A	TCGA-41-5651-01A-01D-1696-08	3672950	223781199	19418174	11	17862											
UGT1A5	54579	broad.mit.edu	37	chr2	234681031	234681031	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcgcgccacacctgcgcccCgcagcccacgacctcacctg	10	22	1	0	rs28900406	byFrequency	TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr2:234681031C>T	uc002vuw.2	+	5	1431	c.1431C>T	c.(1429-1431)CCC>CCT	p.P477P	UGT1A8_uc002vup.2_Silent_p.P473P|UGT1A10_uc002vur.2_Silent_p.P473P|UGT1A9_uc002vus.2_Silent_p.P473P|UGT1A7_uc002vut.2_Silent_p.P473P|UGT1A6_uc002vuu.2_Silent_p.P208P|UGT1A6_uc002vuv.3_Silent_p.P475P|UGT1A4_uc002vux.2_Silent_p.P477P|UGT1A3_uc002vuy.2_Silent_p.P477P|UGT1A9_uc002vva.2_RNA|UGT1A1_uc002vvb.2_Silent_p.P476P	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	477					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		ACCTGCGCCCCGCAGCCCACG	0.602													T	234681031	T	T	234681031	2	4	250	1	0	0	0	0	0	0	0	1	16945	639	23	2		2	UGT1A5	2	234681031	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	10899832	234681031	8518342	12	17863											
CYP8B1	1582	broad.mit.edu	37	chr3	42916203	42916203	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	acagatactcctgcccactgGacatcttcagggtatagtct	8	12	3	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr3:42916203G>A	uc003cmh.2	-	1	1431	c.1106C>T	c.(1105-1107)TCC>TTC	p.S369F	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Missense_Mutation_p.S369F	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	369					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CTGCCCACTGGACATCTTCAG	0.592													A	42916203	A	A	42916203	3	1	250	1	0	0	0	0	1	0	0	0	4198	1174	41	3	403	3	CYP8B1	3	42916203	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08		42916203	155106227	13	17864											
ACY1	95	broad.mit.edu	37	chr3	52020670	52020670	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtcttttatagtgagcggagTccctggtgtaagtatgagct	13	6	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr3:52020670T>C	uc003dcp.2	+	8	637	c.576T>C	c.(574-576)AGT>AGC	p.S192S	ACY1_uc011bea.1_Silent_p.S282S|ACY1_uc011beb.1_Silent_p.S192S|ACY1_uc003dcq.2_Silent_p.S192S	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1	192					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	GTGAGCGGAGTCCCTGGTGTA	0.368													C	52020670	C	C	52020670	2	2	250	1	0	0	0	0	0	0	0	1	226	1664	58	4		4	ACY1	3	52020670	Silent	SNP	T	TCGA-41-5651-01A-01D-1696-08	9104467	52020670	146001760	14	17865											
PIK3CA	5290	broad.mit.edu	37	chr3	178916881	178916881	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgatgaaacaagacgacttTgtgaccttcggctttttcaa	8	8	1	4			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr3:178916881T>G	uc003fjk.2	+	2	425	c.268T>G	c.(268-270)TGT>GGT	p.C90G		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	90	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AAGACGACTTTGTGACCTTCG	0.373		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			G	178916881	G	G	178916881	3	3	250	1	0	0	0	0	1	0	0	0	11913	1812	63	5	270	5	PIK3CA	3	178916881	Missense_Mutation	SNP	T	TCGA-41-5651-01A-01D-1696-08	126896211	178916881	19105549	15	17866											
ABCC5	10057	broad.mit.edu	37	chr3	183679309	183679309	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagatcttacctcaactggcGgtgtctctcccagcaacagg	9	14	3	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr3:183679309G>A	uc003fmg.2	-	16	2534	c.2369C>T	c.(2368-2370)CCG>CTG	p.P790L	ABCC5_uc011bqt.1_Missense_Mutation_p.P318L|ABCC5_uc010hxl.2_Missense_Mutation_p.P790L	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	790						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CTCAACTGGCGGTGTCTCTCC	0.478													A	183679309	A	A	183679309	3	1	250	1	0	0	0	0	1	0	0	0	56	1116	39	2	2004	2	ABCC5	3	183679309	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	4762428	183679309	14343121	16	17867											
RAB28	9364	broad.mit.edu	37	chr4	13481054	13481054	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagactttttagtctcttacCtggcaatgttatccttctca	5	10	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr4:13481054C>A	uc003gmu.2	-	2	387	c.172G>T	c.(172-174)GGA>TGA	p.G58*	RAB28_uc003gmt.2_Nonsense_Mutation_p.G58*|RAB28_uc011bwz.1_Nonsense_Mutation_p.G58*|RAB28_uc003gmv.2_RNA	NM_001017979	NP_001017979	P51157	RAB28_HUMAN	RAB28, member RAS oncogene family isoform 1	58					small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity			ovary(1)|skin(1)	2						AGTCTCTTACCTGGCAATGTT	0.328													A	13481054	A	A	13481054	4	1	250	1	0	0	0	0	0	1	0	0	12916	695	24	5	657	5	RAB28	4	13481054	Nonsense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08		13481054	177673222	17	17868											
GABRA4	2557	broad.mit.edu	37	chr4	46966998	46966998	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtcaaatacctgcagaggggCttcaggatgcttctctctct	10	11	4	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr4:46966998C>A	uc003gxg.2	-	8	1262	c.1123G>T	c.(1123-1125)GCC>TCC	p.A375S		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	375	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGCAGAGGGGCTTCAGGATGC	0.408													A	46966998	A	A	46966998	3	1	250	1	0	0	0	0	1	0	0	0	6163	797	28	5	549	5	GABRA4	4	46966998	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	33485944	46966998	144187278	18	17869											
CDH12	1010	broad.mit.edu	37	chr5	21817224	21817224	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aataggggaagactcaggaaCtttcaagtggaagatgcctg	13	6	2	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr5:21817224C>A	uc010iuc.2	-	6	1290	c.832G>T	c.(832-834)GTT>TTT	p.V278F	CDH12_uc011cno.1_Missense_Mutation_p.V238F|CDH12_uc003jgk.2_Missense_Mutation_p.V278F	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	278	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GACTCAGGAACTTTCAAGTGG	0.363										HNSCC(59;0.17)			A	21817224	A	A	21817224	3	1	250	1	0	0	0	0	1	0	0	0	3098	565	20	5	1580	5	CDH12	5	21817224	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08		21817224	159098036	19	17870											
HEATR7B2	133558	broad.mit.edu	37	chr5	41049447	41049447	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gctgcttcttctcctctgccAtaatcagaattctgatgata	6	11	5	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr5:41049447A>T	uc003jmj.3	-	14	1926	c.1436T>A	c.(1435-1437)ATG>AAG	p.M479K	HEATR7B2_uc003jmi.3_Missense_Mutation_p.M34K	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	479							binding			ovary(6)|central_nervous_system(2)	8						CTCCTCTGCCATAATCAGAAT	0.463													T	41049447	T	T	41049447	3	4	250	1	0	0	0	0	1	0	0	0	7035	217	8	5	3437	5	HEATR7B2	5	41049447	Missense_Mutation	SNP	A	TCGA-41-5651-01A-01D-1696-08	19232223	41049447	139865813	20	17871											
MAP1B	4131	broad.mit.edu	37	chr5	71494424	71494424	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tcgcttctcctctccaagaaGatactctatccgatgttgct	6	13	3	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr5:71494424G>T	uc003kbw.3	+	5	5483	c.5242G>T	c.(5242-5244)GAT>TAT	p.D1748Y	MAP1B_uc010iyw.1_Missense_Mutation_p.D1765Y|MAP1B_uc010iyx.1_Missense_Mutation_p.D1622Y|MAP1B_uc010iyy.1_Missense_Mutation_p.D1622Y	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1748						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TCTCCAAGAAGATACTCTATC	0.478													T	71494424	T	T	71494424	3	4	250	1	0	0	0	0	1	0	0	0	9228	942	33	5	5260	5	MAP1B	5	71494424	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	30444977	71494424	109420836	21	17872											
LHFPL2	10184	broad.mit.edu	37	chr5	77784735	77784735	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ccaaactaaaggaggcagatCagatttttcccctcttcaat	6	11	3	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr5:77784735C>G	uc003kfo.2	-	5	1348	c.672G>C	c.(670-672)CTG>CTC	p.L224L		NM_005779	NP_005770	Q6ZUX7	LHPL2_HUMAN	lipoma HMGIC fusion partner-like 2	224						integral to membrane					0		all_lung(232;0.000409)|Lung NSC(167;0.00108)|Ovarian(174;0.0107)|Prostate(461;0.218)		OV - Ovarian serous cystadenocarcinoma(54;6.48e-46)|Epithelial(54;8.43e-42)|all cancers(79;1.42e-36)		GGAGGCAGATCAGATTTTTCC	0.418													G	77784735	G	G	77784735	2	3	250	1	0	0	0	0	0	0	0	1	8765	813	29	5		5	LHFPL2	5	77784735	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	6290311	77784735	103130525	22	17873											
PKD2L2	27039	broad.mit.edu	37	chr5	137257377	137257377	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttaattttgctggtattcagCaagccaatcctatcttggga	8	8	2	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr5:137257377C>G	uc003lby.2	+	9	1437	c.1381C>G	c.(1381-1383)CAA>GAA	p.Q461E	PKD2L2_uc003lbw.1_Missense_Mutation_p.Q461E|PKD2L2_uc003lbx.2_Intron|PKD2L2_uc011cyi.1_Missense_Mutation_p.Q69E	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	461	Extracellular (Potential).					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGGTATTCAGCAAGCCAATCC	0.308													G	137257377	G	G	137257377	3	3	250	1	0	0	0	0	1	0	0	0	11968	711	25	5	1415	5	PKD2L2	5	137257377	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	59472642	137257377	43657883	23	17874											
ODZ2	57451	broad.mit.edu	37	chr5	167551889	167551889	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cccacctgctccagccacggAgtctgtgtgaatggagaatg	12	12	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr5:167551889A>G	uc010jjd.2	+	11	2043	c.2043A>G	c.(2041-2043)GGA>GGG	p.G681G	ODZ2_uc003lzr.3_Silent_p.G449G|ODZ2_uc003lzt.3_Silent_p.G45G|ODZ2_uc010jje.2_5'UTR|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CCAGCCACGGAGTCTGTGTGA	0.512													G	167551889	G	G	167551889	2	3	250	1	0	0	0	0	0	0	0	1	10835	291	11	4		4	ODZ2	5	167551889	Silent	SNP	A	TCGA-41-5651-01A-01D-1696-08	30294512	167551889	13363371	24	17875											
TRIM10	10107	broad.mit.edu	37	chr6	30126364	30126364	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagaaacttcctcaggtgtgCgaactcagaaatcacctgtt	8	10	3	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr6:30126364C>T	uc003npo.3	-	3	644	c.568G>A	c.(568-570)GCA>ACA	p.A190T	TRIM10_uc003npn.2_Missense_Mutation_p.A190T	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	190						cytoplasm	zinc ion binding				0						CTCAGGTGTGCGAACTCAGAA	0.512													T	30126364	T	T	30126364	3	4	250	1	0	0	0	0	1	0	0	0	16483	768	27	1	985	1	TRIM10	6	30126364	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08		30126364	140988703	25	17876											
TAP2	6891	broad.mit.edu	37	chr6	32782142	32782142	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caggctggagtgatcgacaaGgcaggtgtagacatgtccaa	14	8	0	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr6:32782142G>C	uc011dqf.1	-	14	2541	c.2419C>G	c.(2419-2421)CTT>GTT	p.L807V	HLA-DOB_uc003oca.2_Missense_Mutation_p.L200V|HLA-DOB_uc011dqg.1_Missense_Mutation_p.L200V	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	Error:Variant_position_missing_in_Q03519_after_alignment					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						TGATCGACAAGGCAGGTGTAG	0.502													C	32782142	C	C	32782142	3	2	250	1	0	0	0	0	1	0	0	0	15548	1000	35	5		5	TAP2	6	32782142	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	2655778	32782142	138332925	26	17877											
DNAH8	1769	broad.mit.edu	37	chr6	38840400	38840400	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgttatcacgattctaatgaAggcgcaaacagaatgcggaa	10	8	2	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr6:38840400A>G	uc003ooe.1	+	48	7028	c.6428A>G	c.(6427-6429)AAG>AGG	p.K2143R		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATTCTAATGAAGGCGCAAACA	0.453													G	38840400	G	G	38840400	3	3	250	1	0	0	0	0	1	0	0	0	4607	72	3	4	6610	4	DNAH8	6	38840400	Missense_Mutation	SNP	A	TCGA-41-5651-01A-01D-1696-08	6058258	38840400	132274667	27	17878											
KCNK5	8645	broad.mit.edu	37	chr6	39159464	39159464	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaaagggacagccaggccagCcccaagtagatccagagctc	11	13	0	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr6:39159464C>A	uc003oon.2	-	5	1066	c.702G>T	c.(700-702)GGG>GGT	p.G234G		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	234	Helical; (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GCCAGGCCAGCCCCAAGTAGA	0.577													A	39159464	A	A	39159464	2	1	250	1	0	0	0	0	0	0	0	1	8069	726	26	5		5	KCNK5	6	39159464	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	319064	39159464	131955603	28	17879											
LRFN2	57497	broad.mit.edu	37	chr6	40360425	40360425	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagaccagcagcgtggccaCgatgatgcccccgatgacca	12	14	0	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr6:40360425C>T	uc003oph.1	-	3	2092	c.1627G>A	c.(1627-1629)GTG>ATG	p.V543M		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	543	Helical; (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCGTGGCCACGATGATGCCC	0.607													T	40360425	T	T	40360425	3	4	250	1	0	0	0	0	1	0	0	0	8938	536	19	1	746	1	LRFN2	6	40360425	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	1200961	40360425	130754642	29	17880											
TREML1	340205	broad.mit.edu	37	chr6	41121571	41121571	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atccaccatgcagccatactCgccagcatcctcttcctgca	5	18	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr6:41121571C>T	uc011duc.1	-	2	345	c.301G>A	c.(301-303)GAG>AAG	p.E101K	TREML1_uc003opx.2_Missense_Mutation_p.E101K|TREML1_uc011dud.1_Intron	NM_178174	NP_835468	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid	101	Ig-like V-type.|Extracellular (Potential).				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					CAGCCATACTCGCCAGCATCC	0.602													T	41121571	T	T	41121571	3	4	250	1	0	0	0	0	1	0	0	0	16469	893	31	2	652	2	TREML1	6	41121571	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	761146	41121571	129993496	30	17881											
TDRD6	221400	broad.mit.edu	37	chr6	46658201	46658201	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tacagtagaagtcagagtgtCttatgttgaaaaccctggct	10	7	2	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr6:46658201C>G	uc003oyj.2	+	1	2336	c.2336C>G	c.(2335-2337)TCT>TGT	p.S779C	TDRD6_uc010jze.2_Missense_Mutation_p.S773C	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	779					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GTCAGAGTGTCTTATGTTGAA	0.388													G	46658201	G	G	46658201	3	3	250	1	0	0	0	0	1	0	0	0	15731	913	32	5	2338	5	TDRD6	6	46658201	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	5536630	46658201	124456866	31	17882											
KIF25	3834	broad.mit.edu	37	chr6	168443352	168443352	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagcaccgtggccatgcccCgtaccggaacagcaggctca	13	15	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr6:168443352C>T	uc003qwk.1	+	8	1203	c.941C>T	c.(940-942)CCG>CTG	p.P314L	KIF25_uc003qwl.1_Intron	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	314					microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GGCCATGCCCCGTACCGGAAC	0.652													T	168443352	T	T	168443352	3	4	250	1	0	0	0	0	1	0	0	0	8293	652	23	2	967	2	KIF25	6	168443352	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	121785151	168443352	2671715	32	17883											
ZDHHC4	55146	broad.mit.edu	37	chr7	6628405	6628405	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgactgggcctggtgccagcGttgtccccttgtggcctggc	15	13	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr7:6628405G>A	uc003sqi.2	+	9	1257	c.899G>A	c.(898-900)CGT>CAT	p.R300H	ZDHHC4_uc003sql.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqh.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqj.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqk.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqm.2_Missense_Mutation_p.R300H|uc011jwy.1_5'Flank|C7orf26_uc003sqo.1_5'Flank|C7orf26_uc003sqp.1_5'Flank|C7orf26_uc003sqq.1_5'Flank	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	300						integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		TGGTGCCAGCGTTGTCCCCTT	0.577													A	6628405	A	A	6628405	3	1	250	1	0	0	0	0	1	0	0	0	17614	1145	40	1	921	1	ZDHHC4	7	6628405	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08		6628405	152510258	33	17884											
GHRHR	2692	broad.mit.edu	37	chr7	31014610	31014610	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggacctggacgacacctcCccctactggtggatcatcaa	10	14	2	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr7:31014610C>T	uc003tbx.2	+	9	885	c.837C>T	c.(835-837)TCC>TCT	p.S279S	GHRHR_uc003tbw.1_Silent_p.S279S|GHRHR_uc003tby.2_Silent_p.S215S|GHRHR_uc003tbz.2_Missense_Mutation_p.P46S	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	279	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	ACGACACCTCCCCCTACTGGT	0.587											OREG0017943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	31014610	T	T	31014610	2	4	250	1	0	0	0	0	0	0	0	1	6373	610	22	3		3	GHRHR	7	31014610	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	24386205	31014610	128124053	34	17885											
SAMD9L	219285	broad.mit.edu	37	chr7	92765183	92765183	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcttcactgagcagaatttgCccgtattgctcattaatctt	6	10	4	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr7:92765183C>T	uc003umh.1	-	5	1318	c.102G>A	c.(100-102)GGG>GGA	p.G34G	SAMD9L_uc003umj.1_Silent_p.G34G|SAMD9L_uc003umi.1_Silent_p.G34G|SAMD9L_uc010lfb.1_Silent_p.G34G|SAMD9L_uc003umk.1_Silent_p.G34G|SAMD9L_uc010lfc.1_Silent_p.G34G|SAMD9L_uc010lfd.1_Silent_p.G34G|SAMD9L_uc011khx.1_Silent_p.G25G	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	34	SAM.									ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			GCAGAATTTGCCCGTATTGCT	0.403													T	92765183	T	T	92765183	2	4	250	1	0	0	0	0	0	0	0	1	13827	726	26	3		3	SAMD9L	7	92765183	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	61750573	92765183	66373480	35	17886											
CNTNAP2	26047	broad.mit.edu	37	chr7	147844679	147844679	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caacgatgaccagtggcaccGggtcactgcagagaggaatg	14	10	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr7:147844679G>A	uc003weu.1	+	17	3167	c.2651G>A	c.(2650-2652)CGG>CAG	p.R884Q		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	884	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAGTGGCACCGGGTCACTGCA	0.582										HNSCC(39;0.1)			A	147844679	A	A	147844679	3	1	250	1	0	0	0	0	1	0	0	0	3647	1116	39	2	2717	2	CNTNAP2	7	147844679	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	55079496	147844679	11293984	36	17887											
UBE3C	9690	broad.mit.edu	37	chr7	156963055	156963055	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttgtcacagtccgggggcGcttttcccattgctaatggc	11	13	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr7:156963055G>A	uc010lqs.2	+	4	565	c.253G>A	c.(253-255)GCT>ACT	p.A85T	UBE3C_uc003wnf.2_Missense_Mutation_p.A42T|UBE3C_uc003wng.2_Missense_Mutation_p.A85T	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	85					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		GTCCGGGGGCGCTTTTCCCAT	0.398													A	156963055	A	A	156963055	3	1	250	1	0	0	0	0	1	0	0	0	16878	1087	38	1	267	1	UBE3C	7	156963055	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	9118376	156963055	2175608	37	17888											
ADAM28	10863	broad.mit.edu	37	chr8	24199261	24199261	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaatggaactaagtgtggCgataacaaggtaagttgaaa	12	5	0	1	rs149263503	byFrequency	TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr8:24199261C>T	uc003xdy.2	+	16	1904	c.1821C>T	c.(1819-1821)GGC>GGT	p.G607G	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Silent_p.G294G	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	607	Extracellular (Potential).|Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CTAAGTGTGGCGATAACAAGG	0.408													T	24199261	T	T	24199261	2	4	250	1	0	0	0	0	0	0	0	1	246	755	27	1		1	ADAM28	8	24199261	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08		24199261	122164761	38	17889											
PXDNL	137902	broad.mit.edu	37	chr8	52387699	52387699	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagggcgttggaatccagaCgcctaggcatgcaggcaaga	14	11	0	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr8:52387699C>T	uc003xqu.3	-	7	628	c.527G>A	c.(526-528)CGT>CAT	p.R176H		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	176					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGAATCCAGACGCCTAGGCAT	0.468													T	52387699	T	T	52387699	3	4	250	1	0	0	0	0	1	0	0	0	12848	536	19	1	3932	1	PXDNL	8	52387699	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	28188438	52387699	93976323	39	17890											
C8orf38	137682	broad.mit.edu	37	chr8	96047748	96047748	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agttttggaaaaaaactgtgGaagatatatactgtgacaat	9	3	0	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr8:96047748G>A	uc003yhj.2	+	3	380	c.364G>A	c.(364-366)GAA>AAA	p.E122K	C8orf38_uc003yhe.1_RNA|C8orf38_uc003yhf.2_Missense_Mutation_p.E30K|C8orf38_uc011lgs.1_RNA|C8orf38_uc003yhi.2_Missense_Mutation_p.E70K|C8orf38_uc003yhk.2_RNA|C8orf38_uc003yhl.2_Missense_Mutation_p.E30K	NM_152416	NP_689629	Q330K2	CH038_HUMAN	hypothetical protein LOC137682 precursor	122					biosynthetic process	mitochondrion	transferase activity				0	Breast(36;3.32e-06)					AAAAACTGTGGAAGATATATA	0.328													A	96047748	A	A	96047748	3	1	250	1	0	0	0	0	1	0	0	0	2424	1175	41	3	374	3	C8orf38	8	96047748	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	43660049	96047748	50316274	40	17891											
PKHD1L1	93035	broad.mit.edu	37	chr8	110454293	110454293	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaatgtgtctgtgggggacaCagtggcatggcattggcaaa	15	6	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr8:110454293C>A	uc003yne.2	+	35	4366	c.4262C>A	c.(4261-4263)ACA>AAA	p.T1421K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1421	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGGGGGACACAGTGGCATGG	0.418										HNSCC(38;0.096)			A	110454293	A	A	110454293	3	1	250	1	0	0	0	0	1	0	0	0	11972	478	17	5	4400	5	PKHD1L1	8	110454293	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	14406545	110454293	35909729	41	17892											
DEPDC6	64798	broad.mit.edu	37	chr8	120977651	120977651	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcatggcatcatccagcatgGtgagcgtattgggcagcttt	13	9	1	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr8:120977651G>T	uc003yow.3	+	4	791	c.604_splice	c.e4+1	p.V202_splice	DEPDC6_uc011lid.1_Splice_Site_p.V101_splice	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6						intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATCCAGCATGGTGAGCgtatt	0.303													T	120977651	T	T	120977651	5	4	250	1	0	0	0	0	0	0	1	0	4443	1275	44	5	619	5	DEPDC6	8	120977651	Splice_Site	SNP	G	TCGA-41-5651-01A-01D-1696-08	10523358	120977651	25386371	42	17893											
ADCY8	114	broad.mit.edu	37	chr8	132002709	132002709	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtctccaggaaagcttggCgctgggcccggtctgacagg	16	11	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr8:132002709C>T	uc003ytd.3	-	2	1296	c.1040G>A	c.(1039-1041)CGC>CAC	p.R347H	ADCY8_uc010mds.2_Missense_Mutation_p.R347H	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	347	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GAAAGCTTGGCGCTGGGCCCG	0.522										HNSCC(32;0.087)			T	132002709	T	T	132002709	3	4	250	1	0	0	0	0	1	0	0	0	300	768	27	1	2783	1	ADCY8	8	132002709	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	11025058	132002709	14361313	43	17894											
ACO1	48	broad.mit.edu	37	chr9	32430435	32430435	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gggagaccttgtagctgttgGagtactatctggaaacagga	14	6	1	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr9:32430435G>T	uc003zqw.3	+	14	1744	c.1589G>T	c.(1588-1590)GGA>GTA	p.G530V	ACO1_uc010mjh.1_Missense_Mutation_p.G364V|ACO1_uc003zqx.3_Missense_Mutation_p.G530V|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	530					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		GTAGCTGTTGGAGTACTATCT	0.453													T	32430435	T	T	32430435	3	4	250	1	0	0	0	0	1	0	0	0	146	1174	41	5	1639	5	ACO1	9	32430435	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08		32430435	108782996	44	17895											
DAPK1	1612	broad.mit.edu	37	chr9	90220082	90220082	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aagacggacgtcatcctgatCttggaactgtgagtgccgcc	12	11	2	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr9:90220082C>T	uc004apc.2	+	3	414	c.276C>T	c.(274-276)ATC>ATT	p.I92I	DAPK1_uc004ape.2_Silent_p.I92I|DAPK1_uc004apd.2_Silent_p.I92I|DAPK1_uc011ltg.1_Silent_p.I92I|DAPK1_uc011lth.1_5'UTR	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	92	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						TCATCCTGATCTTGGAACTGT	0.612									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				T	90220082	T	T	90220082	2	4	250	1	0	0	0	0	0	0	0	1	4235	903	32	3		3	DAPK1	9	90220082	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	57789647	90220082	50993349	45	17896											
SNX30	401548	broad.mit.edu	37	chr9	115580093	115580093	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	cccagcccactcatctcattCccgtaggtagtaagtcacta	6	15	3	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr9:115580093C>G	uc004bgj.3	+	3	605	c.457C>G	c.(457-459)CCC>GCC	p.P153A		NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	153	PX.				cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						TCATCTCATTCCCGTAGGTAG	0.458													G	115580093	G	G	115580093	3	3	250	1	0	0	0	0	1	0	0	0	14900	855	30	5	467	5	SNX30	9	115580093	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	25360011	115580093	25633338	46	17897											
OR1J1	347168	broad.mit.edu	37	chr9	125239495	125239495	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggatccacaagtggacaaGgctttgcatatgcccttggt	12	9	0	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr9:125239495G>A	uc011lyu.1	-	1	711	c.711C>T	c.(709-711)GCC>GCT	p.A237A	OR1J2_uc004bmj.1_Intron	NM_001004451	NP_001004451	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J,	237	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						AAGTGGACAAGGCTTTGCATA	0.468													A	125239495	A	A	125239495	2	1	250	1	0	0	0	0	0	0	0	1	10959	987	35	3		3	OR1J1	9	125239495	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08	9659402	125239495	15973936	47	17898											
SDCCAG3	10807	broad.mit.edu	37	chr9	139299619	139299619	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtcgctttcctccttgatcAtttttgcttctaacttccgc	5	13	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr9:139299619A>G	uc004chi.2	-	7	1134	c.929T>C	c.(928-930)ATG>ACG	p.M310T	SDCCAG3_uc004chj.2_Missense_Mutation_p.M287T|SDCCAG3_uc004chk.2_Missense_Mutation_p.M237T	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	310	Potential.					cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		CTCCTTGATCATTTTTGCTTC	0.463													G	139299619	G	G	139299619	3	3	250	1	0	0	0	0	1	0	0	0	13958	217	8	4	394	4	SDCCAG3	9	139299619	Missense_Mutation	SNP	A	TCGA-41-5651-01A-01D-1696-08	14060124	139299619	1913812	48	17899											
ARMC3	219681	broad.mit.edu	37	chr10	23321938	23321938	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaggaatcttctaccatcgaGctttgcttttcaaggtgtgt	9	8	3	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr10:23321938G>T	uc001irm.3	+	18	2478	c.2395G>T	c.(2395-2397)GCT>TCT	p.A799S	ARMC3_uc010qcv.1_Missense_Mutation_p.A792S|ARMC3_uc010qcw.1_Missense_Mutation_p.A536S	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	799							binding				0						CTACCATCGAGCTTTGCTTTT	0.353													T	23321938	T	T	23321938	3	4	250	1	0	0	0	0	1	0	0	0	952	971	34	5	2461	5	ARMC3	10	23321938	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08		23321938	112212809	49	17900											
C10orf119	79892	broad.mit.edu	37	chr10	121600464	121600464	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctagtggaaggacatctcttCttgtatatctagaaaagaaa	8	6	3	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr10:121600464C>A	uc001ler.2	-	11	1437	c.1139G>T	c.(1138-1140)AGA>ATA	p.R380I	C10orf119_uc001leq.1_Missense_Mutation_p.R205I|C10orf119_uc001les.1_Missense_Mutation_p.R205I	NM_024834	NP_079110	Q9BTE3	MCMBP_HUMAN	chromosome 10 open reading frame 119	380					cell division|DNA-dependent DNA replication|mitosis|S phase of mitotic cell cycle|sister chromatid cohesion	nucleus	chromatin binding				0		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.0044)		GACATCTCTTCTTGTATATCT	0.328													A	121600464	A	A	121600464	3	1	250	1	0	0	0	0	1	0	0	0	1588	913	32	5	813	5	C10orf119	10	121600464	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	98278526	121600464	13934283	50	17901											
CHRNA10	57053	broad.mit.edu	37	chr11	3690464	3690464	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctggccgccacacaagactGctggggatgcggatggcatc	14	12	1	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr11:3690464G>A	uc001lyf.2	-	3	396	c.324C>T	c.(322-324)AGC>AGT	p.S108S	CHRNA10_uc010qxt.1_5'UTR|CHRNA10_uc010qxu.1_5'UTR	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	108	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	ACACAAGACTGCTGGGGATGC	0.567													A	3690464	A	A	3690464	2	1	250	1	0	0	0	0	0	0	0	1	3382	1310	46	3		3	CHRNA10	11	3690464	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08		3690464	131316052	51	17902											
MICAL2	9645	broad.mit.edu	37	chr11	12241780	12241780	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagagatgctgctgtgtgcGgagaacgtgaaccaagacaa	13	8	0	4			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr11:12241780G>A	uc001mjz.2	+	9	1269	c.981G>A	c.(979-981)GCG>GCA	p.A327A	MICAL2_uc010rch.1_Silent_p.A327A|MICAL2_uc001mka.2_Silent_p.A327A|MICAL2_uc010rci.1_Silent_p.A327A|MICAL2_uc001mkb.2_Silent_p.A327A|MICAL2_uc001mkc.2_Silent_p.A327A|MICAL2_uc001mkd.2_Silent_p.A156A|MICAL2_uc010rcj.1_5'Flank	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	327						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TGCTGTGTGCGGAGAACGTGA	0.527													A	12241780	A	A	12241780	2	1	250	1	0	0	0	0	0	0	0	1	9570	1103	39	2		2	MICAL2	11	12241780	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08	8551316	12241780	122764736	52	17903											
PYGM	5837	broad.mit.edu	37	chr11	64514249	64514249	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccagaggtggctatgttcCggatcaccatccgcgtccac	11	14	1	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr11:64514249C>T	uc001oax.3	-	20	3228	c.2411G>A	c.(2410-2412)CGG>CAG	p.R804Q	RASGRP2_uc009ypu.2_5'Flank|RASGRP2_uc009ypv.2_5'Flank|RASGRP2_uc009ypw.2_5'Flank|RASGRP2_uc001oaw.1_5'Flank|PYGM_uc001oay.3_Missense_Mutation_p.R716Q	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	804					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	GGCTATGTTCCGGATCACCAT	0.607													T	64514249	T	T	64514249	3	4	250	1	0	0	0	0	1	0	0	0	12862	652	23	2	121	2	PYGM	11	64514249	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	52272469	64514249	70492267	53	17904											
PDGFD	80310	broad.mit.edu	37	chr11	103780460	103780460	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgcagatacaatcacatcGttcatggtgatccaactgga	9	10	2	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr11:103780460G>A	uc001phq.2	-	7	1447	c.1075C>T	c.(1075-1077)CGA>TGA	p.R359*	PDGFD_uc001php.2_Nonsense_Mutation_p.R353*	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	359					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		CAATCACATCGTTCATGGTGA	0.448													A	103780460	A	A	103780460	4	1	250	1	0	0	0	0	0	1	0	0	11660	1153	40	1	41	1	PDGFD	11	103780460	Nonsense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	39266211	103780460	31226056	54	17905											
NLRX1	79671	broad.mit.edu	37	chr11	119054075	119054075	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccacccttaatccttggcGcaaggcccagctgctgcgag	11	15	0	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr11:119054075G>A	uc001pvu.2	+	10	3070	c.2855G>A	c.(2854-2856)CGC>CAC	p.R952H	NLRX1_uc001pvv.2_Intron|NLRX1_uc001pvw.2_Missense_Mutation_p.R952H|NLRX1_uc001pvx.2_Missense_Mutation_p.R952H|PDZD3_uc001pvy.2_5'Flank|PDZD3_uc001pvz.2_5'Flank|PDZD3_uc010rzd.1_5'Flank|PDZD3_uc001pwa.2_5'Flank|PDZD3_uc001pwb.2_5'Flank	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	952	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		AATCCTTGGCGCAAGGCCCAG	0.637													A	119054075	A	A	119054075	3	1	250	1	0	0	0	0	1	0	0	0	10485	1087	38	1	2889	1	NLRX1	11	119054075	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	15273615	119054075	15952441	55	17906											
ARHGAP32	9743	broad.mit.edu	37	chr11	128910863	128910863	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtcactgactggggaactttTtggttaattaactcaacaca	8	8	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr11:128910863T>A	uc009zcp.2	-	10	963	c.963A>T	c.(961-963)CAA>CAT	p.Q321H	ARHGAP32_uc009zcq.1_Missense_Mutation_p.Q281H|ARHGAP32_uc001qfb.2_Missense_Mutation_p.Q106H	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	321	SH3.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GGGGAACTTTTTGGTTAATTA	0.393													A	128910863	A	A	128910863	3	1	250	1	0	0	0	0	1	0	0	0	881	1838	64	5	5352	5	ARHGAP32	11	128910863	Missense_Mutation	SNP	T	TCGA-41-5651-01A-01D-1696-08	9856788	128910863	6095653	56	17907											
KLRG1	10219	broad.mit.edu	37	chr12	9142272	9142272	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccatgttagagttgcctaCggcaacccaagcccagaatg	9	12	0	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr12:9142272C>T	uc001qvh.2	+	1	52	c.41C>T	c.(40-42)ACG>ATG	p.T14M	KLRG1_uc001qvg.2_Missense_Mutation_p.T14M	NM_005810	NP_005801	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G,	14	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			central_nervous_system(1)	1						GAGTTGCCTACGGCAACCCAA	0.413													T	9142272	T	T	9142272	3	4	250	1	0	0	0	0	1	0	0	0	8421	536	19	1	43	1	KLRG1	12	9142272	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08		9142272	124709623	57	17908											
KIF5A	3798	broad.mit.edu	37	chr12	57963411	57963411	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggagaaggagaagacaaaGgcccagaaggagacgattgc	15	6	0	5			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr12:57963411G>A	uc001sor.1	+	11	1270	c.1062G>A	c.(1060-1062)AAG>AAA	p.K354K	KIF5A_uc010srr.1_Silent_p.K265K	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	354					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						agaagacaaaggcccagaagg	0.423													A	57963411	A	A	57963411	2	1	250	1	0	0	0	0	0	0	0	1	8305	991	35	3		3	KIF5A	12	57963411	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08	48821139	57963411	75888484	58	17909											
OS9	10956	broad.mit.edu	37	chr12	58109576	58109576	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agggtgcaggtatctctgggGactacatcgatcgcgtggac	15	9	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr12:58109576G>A	uc001spj.2	+	6	672	c.613G>A	c.(613-615)GAC>AAC	p.D205N	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Missense_Mutation_p.D205N|OS9_uc001spl.2_Missense_Mutation_p.D205N|OS9_uc001spm.2_Missense_Mutation_p.D205N|OS9_uc001spn.2_Missense_Mutation_p.D205N|OS9_uc010sry.1_Missense_Mutation_p.D172N|OS9_uc010srz.1_Missense_Mutation_p.D146N	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	205					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TATCTCTGGGGACTACATCGA	0.517													A	58109576	A	A	58109576	3	1	250	1	0	0	0	0	1	0	0	0	11272	1174	41	3	635	3	OS9	12	58109576	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	146165	58109576	75742319	59	17910											
AVIL	10677	broad.mit.edu	37	chr12	58204641	58204641	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctctctgggccattccattgGatgatgactttcccaaggtc	9	12	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr12:58204641G>A	uc001sqj.1	-	5	545	c.516C>T	c.(514-516)ATC>ATT	p.I172I	AVIL_uc009zqe.1_Silent_p.I165I|AVIL_uc001sqk.1_5'Flank|AVIL_uc001sql.3_Silent_p.I149I	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	172	Gelsolin-like 2.|Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CATTCCATTGGATGATGACTT	0.502													A	58204641	A	A	58204641	2	1	250	1	0	0	0	0	0	0	0	1	1227	1164	41	3		3	AVIL	12	58204641	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08	95065	58204641	75647254	60	17911											
LRIG3	121227	broad.mit.edu	37	chr12	59268350	59268351	+	Frame_Shift_Ins	INS	-	G	G													ctgctattgtcaatatggcaINSggtccctttgaaacaaaaat							TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr12:59268350_59268351insG	uc001sqr.2	-	17	2946_2947	c.2700_2701insC	c.(2698-2703)ACCTGCfs	p.T900fs	LRIG3_uc009zqh.2_Frame_Shift_Ins_p.T840fs|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	900_901						integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			TCAATATGGCAGGTCCCTTTGA	0.401													G	59268351	G	G	59268350	7	5	250	1	0	1	1	0	0	0	0	0	8946	188	7	0	670	0	LRIG3	12	59268350	Frame_Shift_Ins	INS	-	TCGA-41-5651-01A-01D-1696-08	1063709	59268350	74583545	61	17912											
ACIN1	22985	broad.mit.edu	37	chr14	23564497	23564497	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgtttccgtctccacatcGttaccaatcaattctttcca	4	13	3	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr14:23564497G>A	uc001wit.3	-	1	327	c.-1C>T	c.(-3-1)AACGA>AATGA		ACIN1_uc010akg.2_Translation_Start_Site|ACIN1_uc010tnj.1_Translation_Start_Site|C14orf119_uc001wiu.2_5'Flank	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1						apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TCTCCACATCGTTACCAATCA	0.542													A	23564497	A	A	23564497	1	1	250	1	0	0	0	0	0	0	0	0	142	1160	40	1		1	ACIN1	14	23564497	Translation_Start_Site	SNP	G	TCGA-41-5651-01A-01D-1696-08		23564497	83785043	62	17913											
MYH6	4624	broad.mit.edu	37	chr14	23857466	23857466	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcattctgtagccggtgcttGgtcttctccagtgaggagca	12	10	4	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr14:23857466G>C	uc001wjv.2	-	30	4324	c.4257C>G	c.(4255-4257)ACC>ACG	p.T1419T		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1419	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCCGGTGCTTGGTCTTCTCCA	0.572													C	23857466	C	C	23857466	2	2	250	1	0	0	0	0	0	0	0	1	10038	1335	47	5		5	MYH6	14	23857466	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08	292969	23857466	83492074	63	17914											
KCNH5	27133	broad.mit.edu	37	chr14	63468087	63468087	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctattggctgtttgaacaacGtaatatccttgaaagtacac	7	8	0	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr14:63468087G>A	uc001xfx.2	-	4	446	c.395C>T	c.(394-396)ACG>ATG	p.T132M	KCNH5_uc001xfy.2_Missense_Mutation_p.T132M|KCNH5_uc001xfz.1_Missense_Mutation_p.T74M|KCNH5_uc001xga.2_Missense_Mutation_p.T74M	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	132	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTTGAACAACGTAATATCCTT	0.343													A	63468087	A	A	63468087	3	1	250	1	0	0	0	0	1	0	0	0	8035	1145	40	1	2637	1	KCNH5	14	63468087	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	39610621	63468087	43881453	64	17915											
LTBP2	4053	broad.mit.edu	37	chr14	74971518	74971518	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaaacgtccaggctccttcCacaggaatgtagccttttcc	7	15	0	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr14:74971518C>T	uc001xqa.2	-	30	4803	c.4416G>A	c.(4414-4416)GTG>GTA	p.V1472V		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1472					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGGCTCCTTCCACAGGAATGT	0.562													T	74971518	T	T	74971518	2	4	250	1	0	0	0	0	0	0	0	1	9074	581	21	3		3	LTBP2	14	74971518	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	11503431	74971518	32378022	65	17916											
STON2	85439	broad.mit.edu	37	chr14	81744722	81744722	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcattcaggaaagggttggtTgccctccaaggtgaagcctc	12	10	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr14:81744722T>G	uc010tvu.1	-	4	1134	c.933A>C	c.(931-933)GCA>GCC	p.A311A	STON2_uc001xvk.1_Silent_p.A311A|STON2_uc010tvt.1_Silent_p.A108A	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	311					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		AAGGGTTGGTTGCCCTCCAAG	0.498													G	81744722	G	G	81744722	2	3	250	1	0	0	0	0	0	0	0	1	15317	1799	63	5		5	STON2	14	81744722	Silent	SNP	T	TCGA-41-5651-01A-01D-1696-08	6773204	81744722	25604818	66	17917											
KIAA1409	57578	broad.mit.edu	37	chr14	94069684	94069684	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaccgccagaagagtgtacGttccctgagggacagcgtga	13	10	0	4			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr14:94069684G>A	uc001ybv.1	+	23	3226	c.3143G>A	c.(3142-3144)CGT>CAT	p.R1048H	KIAA1409_uc001ybs.1_Missense_Mutation_p.R1048H	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1225						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AAGAGTGTACGTTCCCTGAGG	0.527													A	94069684	A	A	94069684	3	1	250	1	0	0	0	0	1	0	0	0	8230	1145	40	1	3233	1	KIAA1409	14	94069684	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	12324962	94069684	13279856	67	17918											
SERPINA12	145264	broad.mit.edu	37	chr14	94953697	94953697	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcacggaaggtattttctcGctgtaaatcagcagcagata	10	8	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr14:94953697G>A	uc001ydj.2	-	6	1984	c.1188C>T	c.(1186-1188)AGC>AGT	p.S396S		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	396					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		GTATTTTCTCGCTGTAAATCA	0.527													A	94953697	A	A	94953697	2	1	250	1	0	0	0	0	0	0	0	1	14089	1078	38	1		1	SERPINA12	14	94953697	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08	884013	94953697	12395843	68	17919											
AHNAK2	113146	broad.mit.edu	37	chr14	105411658	105411658	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcgggcacgtggccctccGggagcttcacgtccacctgg	13	17	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr14:105411658G>A	uc010axc.1	-	7	10250	c.10130C>T	c.(10129-10131)CCG>CTG	p.P3377L	AHNAK2_uc001ypx.2_Missense_Mutation_p.P3277L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3377						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTGGCCCTCCGGGAGCTTCAC	0.637													A	105411658	A	A	105411658	3	1	250	1	0	0	0	0	1	0	0	0	415	1116	39	2	7261	2	AHNAK2	14	105411658	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	10457961	105411658	1937882	69	17920											
SHC4	399694	broad.mit.edu	37	chr15	49217141	49217141	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgcagcacttcaacacagccCatgtactacaataagaagaa	6	11	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr15:49217141C>A	uc001zxb.1	-	2	1020	c.591G>T	c.(589-591)ATG>ATT	p.M197I		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	197	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		CAACACAGCCCATGTACTACA	0.413													A	49217141	A	A	49217141	3	1	250	1	0	0	0	0	1	0	0	0	14273	594	21	5	1345	5	SHC4	15	49217141	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08		49217141	53314251	70	17921											
MYO5C	55930	broad.mit.edu	37	chr15	52537563	52537563	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaactgacctggatgagtctGtgtaaaaccaccttgcacac	8	11	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr15:52537563G>A	uc010bff.2	-	18	2303	c.2166C>T	c.(2164-2166)CAC>CAT	p.H722H	MYO5C_uc010uga.1_RNA|MYO5C_uc010ugb.1_RNA	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	722	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		GGATGAGTCTGTGTAAAACCA	0.483													A	52537563	A	A	52537563	2	1	250	1	0	0	0	0	0	0	0	1	10080	1368	48	3		3	MYO5C	15	52537563	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08	3320422	52537563	49993829	71	17922											
CD276	80381	broad.mit.edu	37	chr15	73994767	73994767	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagctttgctgagggccaggAccagggcagcgcctatgcca	14	13	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr15:73994767A>G	uc002avv.1	+	3	485	c.251A>G	c.(250-252)GAC>GGC	p.D84G	CD276_uc010bjd.1_5'UTR|CD276_uc002avu.1_Missense_Mutation_p.D84G|CD276_uc002avw.1_Missense_Mutation_p.D84G|CD276_uc010ulb.1_Missense_Mutation_p.D30G|CD276_uc002avx.2_5'Flank	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a	84	Ig-like V-type 1.|Extracellular (Potential).				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1						GAGGGCCAGGACCAGGGCAGC	0.647													G	73994767	G	G	73994767	3	3	250	1	0	0	0	0	1	0	0	0	2992	275	10	4	257	4	CD276	15	73994767	Missense_Mutation	SNP	A	TCGA-41-5651-01A-01D-1696-08	21457204	73994767	28536625	72	17923											
CIITA	4261	broad.mit.edu	37	chr16	11004047	11004047	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgcctgttctctccaggaCgagaagttcctcggaagaca	10	11	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr16:11004047C>T	uc002dai.3	+	13	2952	c.2819C>T	c.(2818-2820)ACG>ATG	p.T940M	CIITA_uc002daj.3_Missense_Mutation_p.T941M|CIITA_uc002dak.3_Missense_Mutation_p.T356M|CIITA_uc010bup.1_Nonsense_Mutation_p.R337*	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	940			Missing (in BLS2).		interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CTCTCCAGGACGAGAAGTTCC	0.572			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								T	11004047	T	T	11004047	3	4	250	1	0	0	0	0	1	0	0	0	3428	536	19	1	2869	1	CIITA	16	11004047	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08		11004047	79350706	73	17924											
IL4R	3566	broad.mit.edu	37	chr16	27373866	27373866	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cagggatgacttccaggaggGaagggagggcattgtggccc	18	8	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr16:27373866G>C	uc002don.2	+	11	1435	c.1193G>C	c.(1192-1194)GGA>GCA	p.G398A	IL4R_uc002dop.3_Missense_Mutation_p.G383A|IL4R_uc010bxy.2_Missense_Mutation_p.G398A|IL4R_uc002doo.2_Missense_Mutation_p.G238A	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	398	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						TTCCAGGAGGGAAGGGAGGGC	0.597													C	27373866	C	C	27373866	3	2	250	1	0	0	0	0	1	0	0	0	7698	1174	41	5	1245	5	IL4R	16	27373866	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	16369819	27373866	62980887	74	17925											
ELMO3	79767	broad.mit.edu	37	chr16	67235531	67235531	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgcgcatgcggacgcccctgGacccctacagccaggtgtgt	13	16	0	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr16:67235531G>A	uc002esa.2	+	10	1106	c.1063G>A	c.(1063-1065)GAC>AAC	p.D355N	ELMO3_uc002esb.2_Missense_Mutation_p.D338N|ELMO3_uc002esc.2_Missense_Mutation_p.D189N	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	302					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GACGCCCCTGGACCCCTACAG	0.612													A	67235531	A	A	67235531	3	1	250	1	0	0	0	0	1	0	0	0	5067	1174	41	3	1101	3	ELMO3	16	67235531	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	39861665	67235531	23119222	75	17926											
RLTPR	146206	broad.mit.edu	37	chr16	67681849	67681849	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggggcgctgggggcctcCgaggacagtggggtgagtgg	22	9	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr16:67681849C>T	uc002etn.2	+	13	1179	c.1059C>T	c.(1057-1059)TCC>TCT	p.S353S	RLTPR_uc010cel.1_Silent_p.S353S|RLTPR_uc010vjr.1_Silent_p.S353S	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	353	LRR 6.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		TGGGGGCCTCCGAGGACAGTG	0.662													T	67681849	T	T	67681849	2	4	250	1	0	0	0	0	0	0	0	1	13394	639	23	2		2	RLTPR	16	67681849	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	446318	67681849	22672904	76	17927											
TP53	7157	broad.mit.edu	37	chr17	7578555	7578555	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgttgagggcaggggagtaCtgtaggaagaggaaggagac	19	3	0	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr17:7578555C>T	uc002gim.2	-	5	570	c.376_splice	c.e5-1	p.Y126_splice	TP53_uc002gig.1_Splice_Site_p.Y126_splice|TP53_uc002gih.2_Splice_Site_p.Y126_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Splice_Site_p.Y126_splice|TP53_uc010cni.1_Splice_Site_p.Y126_splice|TP53_uc002gij.2_Splice_Site_p.Y126_splice|TP53_uc010cnj.1_Splice_Site|TP53_uc002gin.2_Splice_Site_p.Y33_splice|TP53_uc002gio.2_Splice_Site|TP53_uc010vug.1_Splice_Site_p.Y87_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(31)|p.0?(7)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGGAGTACTGTAGGAAGA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578555	T	T	7578555	5	4	250	1	0	0	0	0	0	0	1	0	16378	579	20	3	923	3	TP53	17	7578555	Splice_Site	SNP	C	TCGA-41-5651-01A-01D-1696-08		7578555	73616655	77	17928											
C17orf46	124783	broad.mit.edu	37	chr17	43332647	43332647	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagtggtgctctggcttcgCgtggtttctctggcagggtc	15	10	3	0	rs144271763		TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr17:43332647C>T	uc002iis.1	-	4	998	c.902G>A	c.(901-903)CGC>CAC	p.R301H	LOC100133991_uc010dah.2_Intron|C17orf46_uc010wjk.1_Missense_Mutation_p.R280H	NM_152343	NP_689556	Q96LK8	CQ046_HUMAN	hypothetical protein LOC124783	301										large_intestine(1)|ovary(1)	2						TCTGGCTTCGCGTGGTTTCTC	0.567													T	43332647	T	T	43332647	3	4	250	1	0	0	0	0	1	0	0	0	1857	768	27	1	260	1	C17orf46	17	43332647	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	35754092	43332647	37862563	78	17929											
SCN4A	6329	broad.mit.edu	37	chr17	62034852	62034852	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcatgttcagcgttggccaCgacttggccagcttgaagac	12	11	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr17:62034852C>T	uc002jds.1	-	13	2123	c.2046G>A	c.(2044-2046)TCG>TCA	p.S682S		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	682	Helical; Voltage-sensor; Name=S4 of repeat II; (Potential).|II.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GCGTTGGCCACGACTTGGCCA	0.592													T	62034852	T	T	62034852	2	4	250	1	0	0	0	0	0	0	0	1	13920	523	19	1		1	SCN4A	17	62034852	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	18702205	62034852	19160358	79	17930											
EVPL	2125	broad.mit.edu	37	chr17	74011625	74011625	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagggcagcggggcccaCgggccgcgtggacagaaacg	18	13	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr17:74011625C>T	uc002jqi.2	-	15	2023	c.1795G>A	c.(1795-1797)GTG>ATG	p.V599M	EVPL_uc010wss.1_Missense_Mutation_p.V621M|EVPL_uc010wst.1_Missense_Mutation_p.V69M	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	599	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						GCGGGGCCCACGGGCCGCGTG	0.647													T	74011625	T	T	74011625	3	4	250	1	0	0	0	0	1	0	0	0	5292	536	19	1	4338	1	EVPL	17	74011625	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	11976773	74011625	7183585	80	17931											
SLC14A2	8170	broad.mit.edu	37	chr18	43262345	43262345	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcaccttcctgctcctgaCgaccaataaccccgccatct	4	19	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr18:43262345C>T	uc010dnj.2	+	21	2945	c.2624C>T	c.(2623-2625)ACG>ATG	p.T875M	SLC14A2_uc002lbe.2_Missense_Mutation_p.T875M	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	875						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CTGCTCCTGACGACCAATAAC	0.547													T	43262345	T	T	43262345	3	4	250	1	0	0	0	0	1	0	0	0	14397	536	19	1	2698	1	SLC14A2	18	43262345	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08		43262345	34814903	81	17932											
MUC16	94025	broad.mit.edu	37	chr19	9033637	9033637	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcagttctctctctgtggcGttgaacttcctggaaccagg	11	11	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr19:9033637G>A	uc002mkp.2	-	9	36504	c.36300C>T	c.(36298-36300)AAC>AAT	p.N12100N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12102	SEA 1.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTCTGTGGCGTTGAACTTCC	0.597													A	9033637	A	A	9033637	2	1	250	1	0	0	0	0	0	0	0	1	9973	1136	40	1		1	MUC16	19	9033637	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08		9033637	50095346	82	17933											
ZNF439	90594	broad.mit.edu	37	chr19	11978931	11978931	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacacataagaatgcactcTggagaaagaccttatgaatg	8	8	1	4			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr19:11978931T>C	uc002mss.2	+	3	1175	c.1047T>C	c.(1045-1047)TCT>TCC	p.S349S	ZNF439_uc002msr.2_Silent_p.S213S	NM_152262	NP_689475	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						GAATGCACTCTGGAGAAAGAC	0.373													C	11978931	C	C	11978931	2	2	250	1	0	0	0	0	0	0	0	1	17908	1567	55	4		4	ZNF439	19	11978931	Silent	SNP	T	TCGA-41-5651-01A-01D-1696-08	2945294	11978931	47150052	83	17934											
SLC1A6	6511	broad.mit.edu	37	chr19	15083572	15083572	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgtttcggcgcaggaagcGcagcacgtgctcgagggtca	17	11	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr19:15083572G>A	uc002naa.1	-	1	159	c.151C>T	c.(151-153)CGC>TGC	p.R51C	SLC1A6_uc010dzu.1_Missense_Mutation_p.R51C|SLC1A6_uc010xod.1_Missense_Mutation_p.A55V|SLC1A6_uc002nab.2_Missense_Mutation_p.R51C|SLC1A6_uc002nac.2_Missense_Mutation_p.R51C|SLC1A6_uc002nad.1_Missense_Mutation_p.R51C	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	51	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	CGCAGGAAGCGCAGCACGTGC	0.677													A	15083572	A	A	15083572	3	1	250	1	0	0	0	0	1	0	0	0	14436	1087	38	1	1579	1	SLC1A6	19	15083572	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	3104641	15083572	44045411	84	17935											
CYP2A13	1553	broad.mit.edu	37	chr19	41597756	41597756	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggagcacaaccagcgcacGctggatcccaattccccacg	10	16	0	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr19:41597756G>A	uc002opt.2	+	5	783	c.774G>A	c.(772-774)ACG>ACA	p.T258T		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	258					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	ACCAGCGCACGCTGGATCCCA	0.587													A	41597756	A	A	41597756	2	1	250	1	0	0	0	0	0	0	0	1	4161	1074	38	1		1	CYP2A13	19	41597756	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08	26514184	41597756	17531227	85	17936											
ATP1A3	478	broad.mit.edu	37	chr19	42489240	42489240	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagtgctcaatctcgatggCgatgggcgtcttgcccacct	12	12	3	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr19:42489240C>T	uc002osg.2	-	8	977	c.823G>A	c.(823-825)GCC>ACC	p.A275T	ATP1A3_uc010xwf.1_Missense_Mutation_p.A286T|ATP1A3_uc010xwg.1_Missense_Mutation_p.A245T|ATP1A3_uc010xwh.1_Missense_Mutation_p.A288T|ATP1A3_uc002osh.2_Missense_Mutation_p.A275T	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	275	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						ATCTCGATGGCGATGGGCGTC	0.632													T	42489240	T	T	42489240	3	4	250	1	0	0	0	0	1	0	0	0	1130	768	27	1	2282	1	ATP1A3	19	42489240	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	891484	42489240	16639743	86	17937											
ZNF324	25799	broad.mit.edu	37	chr19	58982200	58982200	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagcgtcttccctgttgccgGtgcctgccacagtgtaaaaa	10	12	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr19:58982200G>A	uc002qsw.1	+	4	435	c.341G>A	c.(340-342)GGT>GAT	p.G114D	ZNF324_uc002qsx.1_5'Flank	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CCTGTTGCCGGTGCCTGCCAC	0.567													A	58982200	A	A	58982200	3	1	250	1	0	0	0	0	1	0	0	0	17841	1261	44	3	351	3	ZNF324	19	58982200	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	16492960	58982200	146783	87	17938											
KIF16B	55614	broad.mit.edu	37	chr20	16254013	16254013	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttgatgtggaggggagatGttgcggactggagcatcacg	18	5	1	2			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr20:16254013G>A	uc002wpg.1	-	26	3997	c.3839C>T	c.(3838-3840)ACA>ATA	p.T1280I	KIF16B_uc002wpe.1_Missense_Mutation_p.T632I|KIF16B_uc002wpf.1_Missense_Mutation_p.T621I|KIF16B_uc010gch.1_Missense_Mutation_p.T1229I	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1280	PX.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GAGGGGAGATGTTGCGGACTG	0.398													A	16254013	A	A	16254013	3	1	250	1	0	0	0	0	1	0	0	0	8278	1377	48	3	118	3	KIF16B	20	16254013	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08		16254013	46771507	88	17939											
SEC23B	10483	broad.mit.edu	37	chr20	18507120	18507120	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaattaaagattcctattcGttcttggcatgatattgaga	8	5	1	4			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr20:18507120G>A	uc002wqz.1	+	8	1381	c.938G>A	c.(937-939)CGT>CAT	p.R313H	SEC23B_uc002wra.1_Missense_Mutation_p.R313H|SEC23B_uc002wrb.1_Missense_Mutation_p.R313H|SEC23B_uc010zsb.1_Missense_Mutation_p.R295H|SEC23B_uc002wrc.1_Missense_Mutation_p.R313H	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	313			R -> H.		ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						ATTCCTATTCGTTCTTGGCAT	0.458													A	18507120	A	A	18507120	3	1	250	1	0	0	0	0	1	0	0	0	13992	1145	40	1	964	1	SEC23B	20	18507120	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	2253107	18507120	44518400	89	17940											
FAM83D	81610	broad.mit.edu	37	chr20	37555323	37555325	+	In_Frame_Del	DEL	GCG	-	-													agaggccgggagaggagggcGcggcggcggcggcggcggcc							TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr20:37555323_37555325delGCG	uc002xjg.2	+	1	369_371	c.328_330delGCG	c.(328-330)GCGdel	p.A116del	FAM83D_uc002xjf.2_In_Frame_Del_p.A116del	NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	86	Poly-Ala.				cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				AGAGGAGGGCgcggcggcggcgg	0.621													-	37555325	-	-	37555323	7	5	250	1	0	1	0	1	0	0	0	0	5636	1087	38	0	330	0	FAM83D	20	37555323	In_Frame_Del	DEL	GCG	TCGA-41-5651-01A-01D-1696-08	19048203	37555323	25470197	90	17941											
SLC12A5	57468	broad.mit.edu	37	chr20	44674611	44674611	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catcctcattgcatccctcgAcgaggtggcccccatcctct	7	18	2	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr20:44674611A>G	uc010zxl.1	+	13	1809	c.1733A>G	c.(1732-1734)GAC>GGC	p.D578G	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.D555G	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	578	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCATCCCTCGACGAGGTGGCC	0.597													G	44674611	G	G	44674611	3	3	250	1	0	0	0	0	1	0	0	0	14386	275	10	4	1839	4	SLC12A5	20	44674611	Missense_Mutation	SNP	A	TCGA-41-5651-01A-01D-1696-08	7119288	44674611	18350909	91	17942											
NFATC2	4773	broad.mit.edu	37	chr20	50159018	50159018	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccccgccgtcgggttggggCtgccgctcgggggcgttcat	17	14	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr20:50159018C>T	uc002xwd.2	-	1	241	c.21G>A	c.(19-21)CAG>CAA	p.Q7Q	NFATC2_uc002xwc.2_Silent_p.Q7Q|NFATC2_uc010zyv.1_5'UTR|NFATC2_uc010zyw.1_5'UTR|NFATC2_uc010zyx.1_Intron|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Intron	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	7					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					CGGGTTGGGGCTGCCGCTCGG	0.582													T	50159018	T	T	50159018	2	4	250	1	0	0	0	0	0	0	0	1	10362	796	28	3		3	NFATC2	20	50159018	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	5484407	50159018	12866502	92	17943											
OPRL1	4987	broad.mit.edu	37	chr20	62729401	62729401	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccccatccgtgccctcgaCgtccgcacgtccagcaaagc	8	20	0	0	rs143380233		TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr20:62729401C>T	uc002yic.2	+	4	882	c.480C>T	c.(478-480)GAC>GAT	p.D160D	OPRL1_uc002yid.2_Silent_p.D160D|OPRL1_uc002yif.3_Silent_p.D155D	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	160	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GTGCCCTCGACGTCCGCACGT	0.587													T	62729401	T	T	62729401	2	4	250	1	0	0	0	0	0	0	0	1	10886	535	19	1		1	OPRL1	20	62729401	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	12570383	62729401	296119	93	17944											
ITSN1	6453	broad.mit.edu	37	chr21	35231057	35231057	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggttgctatgatttttgtgaActggaaggagctgattatgt	13	3	0	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr21:35231057A>C	uc002yta.1	+	31	4119	c.3851A>C	c.(3850-3852)AAC>ACC	p.N1284T	DONSON_uc002ysn.1_Intron|ITSN1_uc002ytb.1_Missense_Mutation_p.N1279T|ITSN1_uc002ytj.2_Missense_Mutation_p.N1279T|ITSN1_uc010gmm.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1284	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						ATTTTTGTGAACTGGAAGGAG	0.453													C	35231057	C	C	35231057	3	2	250	1	0	0	0	0	1	0	0	0	7926	43	2	5	3975	5	ITSN1	21	35231057	Missense_Mutation	SNP	A	TCGA-41-5651-01A-01D-1696-08		35231057	12898838	94	17945											
IGSF5	150084	broad.mit.edu	37	chr21	41137664	41137664	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcagaggtacgaccagggCgggaacttcacctcggagat	13	11	2	2	rs145170006		TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr21:41137664C>T	uc002yyo.2	+	3	406	c.303C>T	c.(301-303)GGC>GGT	p.G101G		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	101	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				ACGACCAGGGCGGGAACTTCA	0.557													T	41137664	T	T	41137664	2	4	250	1	0	0	0	0	0	0	0	1	7602	755	27	1		1	IGSF5	21	41137664	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	5906607	41137664	6992231	95	17946											
ITGB2	3689	broad.mit.edu	37	chr21	46320382	46320382	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgcgtgacgttgcgccagccGatttcctcctgagaagaagg	13	12	0	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr21:46320382G>A	uc002zgd.2	-	6	794	c.750C>T	c.(748-750)ATC>ATT	p.I250I	ITGB2_uc002zge.2_Silent_p.I250I|ITGB2_uc002zgf.3_Silent_p.I250I|ITGB2_uc011afl.1_Silent_p.I172I|ITGB2_uc010gpw.2_Silent_p.I193I|ITGB2_uc002zgg.2_Silent_p.I250I	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	250	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	TGCGCCAGCCGATTTCCTCCT	0.647													A	46320382	A	A	46320382	2	1	250	1	0	0	0	0	0	0	0	1	7894	1048	37	2		2	ITGB2	21	46320382	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08	5182718	46320382	1809513	96	17947											
SEC14L3	266629	broad.mit.edu	37	chr22	30856050	30856050	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcatatttctgcatgccctcGtcagggagcaggacctccac	9	14	3	0	rs116181219	by1000genomes	TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr22:30856050G>A	uc003ahy.2	-	12	1250	c.1161C>T	c.(1159-1161)GAC>GAT	p.D387D	SEC14L3_uc003ahz.2_Silent_p.D310D|SEC14L3_uc003aia.2_Silent_p.D328D|SEC14L3_uc003aib.2_Silent_p.D328D	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	387						integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	GCATGCCCTCGTCAGGGAGCA	0.502													A	30856050	A	A	30856050	2	1	250	1	0	0	0	0	0	0	0	1	13983	1136	40	1		1	SEC14L3	22	30856050	Silent	SNP	G	TCGA-41-5651-01A-01D-1696-08		30856050	20448516	97	17948											
PES1	23481	broad.mit.edu	37	chr22	30980618	30980618	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaatggtctgcacgtggcacTtgccagtccgcgggaaggtg	16	10	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chr22:30980618T>C	uc003aij.1	-	5	529	c.455A>G	c.(454-456)AAG>AGG	p.K152R	PES1_uc003aik.1_Missense_Mutation_p.K152R|PES1_uc003ail.1_Missense_Mutation_p.K152R|PES1_uc003aim.1_Missense_Mutation_p.K152R|PES1_uc003ain.1_Missense_Mutation_p.K13R|PES1_uc003aio.1_Missense_Mutation_p.K13R	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	152	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						CACGTGGCACTTGCCAGTCCG	0.612													C	30980618	C	C	30980618	3	2	250	1	0	0	0	0	1	0	0	0	11733	1609	56	4	1355	4	PES1	22	30980618	Missense_Mutation	SNP	T	TCGA-41-5651-01A-01D-1696-08	124568	30980618	20323948	98	17949											
MXRA5	25878	broad.mit.edu	37	chrX	3235173	3235173	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgtcgatcatcctcttggaCggcagcctccagaggatgcg	13	13	2	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:3235173C>T	uc004crg.3	-	6	6706	c.6549G>A	c.(6547-6549)CCG>CCA	p.P2183P		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2183	Ig-like C2-type 6.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCCTCTTGGACGGCAGCCTCC	0.637													T	3235173	T	T	3235173	2	4	250	1	0	0	0	0	0	0	0	1	10003	523	19	1		1	MXRA5	23	3235173	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08		3235173	152035387	99	17950											
TLR7	51284	broad.mit.edu	37	chrX	12905182	12905182	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attttcagcatctttctttcCtcaaatgcctgaatctgtca	4	11	6	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:12905182C>A	uc004cvc.2	+	3	1694	c.1555C>A	c.(1555-1557)CTC>ATC	p.L519I		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	519	Extracellular (Potential).|LRR 17.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	TCTTTCTTTCCTCAAATGCCT	0.378													A	12905182	A	A	12905182	3	1	250	1	0	0	0	0	1	0	0	0	15953	681	24	5	1561	5	TLR7	23	12905182	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	9670009	12905182	142365378	100	17951											
DDX53	168400	broad.mit.edu	37	chrX	23019720	23019720	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtagaggactttaaaagcGgaaacataaagatactgatt	9	5	0	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:23019720G>A	uc004daj.2	+	1	1634	c.1546G>A	c.(1546-1548)GGA>AGA	p.G516R		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	516	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						CTTTAAAAGCGGAAACATAAA	0.373													A	23019720	A	A	23019720	3	1	250	1	0	0	0	0	1	0	0	0	4371	1117	39	2	1548	2	DDX53	23	23019720	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	10114538	23019720	132250840	101	17952											
CXorf21	80231	broad.mit.edu	37	chrX	30577750	30577750	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgtcatgatgagttcagaCgccagaatctgggtaggaga	13	7	3	5			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:30577750C>T	uc004dcg.1	-	3	999	c.723G>A	c.(721-723)GCG>GCA	p.A241A		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	241										ovary(1)	1						TGAGTTCAGACGCCAGAATCT	0.438													T	30577750	T	T	30577750	2	4	250	1	0	0	0	0	0	0	0	1	4101	523	19	1		1	CXorf21	23	30577750	Silent	SNP	C	TCGA-41-5651-01A-01D-1696-08	7558030	30577750	124692810	102	17953											
GRIPAP1	56850	broad.mit.edu	37	chrX	48839756	48839756	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcacctccttctcatgccGtagacgaactgctcccagct	7	17	1	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:48839756G>A	uc004dly.1	-	16	1404	c.1369C>T	c.(1369-1371)CGG>TGG	p.R457W	GRIPAP1_uc004dlz.2_Missense_Mutation_p.R347W|GRIPAP1_uc004dma.2_Missense_Mutation_p.R404W	NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1	457	Potential.					early endosome				breast(2)|kidney(1)	3						TTCTCATGCCGTAGACGAACT	0.597													A	48839756	A	A	48839756	3	1	250	1	0	0	0	0	1	0	0	0	6789	1144	40	1	1254	1	GRIPAP1	23	48839756	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	18262006	48839756	106430804	103	17954											
ITIH5L	347365	broad.mit.edu	37	chrX	54785423	54785423	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccagcagagctgagttgaCgtctgtccctaattggggaa	13	9	1	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:54785423C>T	uc004dtj.2	-	8	1114	c.1084G>A	c.(1084-1086)GTC>ATC	p.V362I		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	362	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GCTGAGTTGACGTCTGTCCCT	0.547													T	54785423	T	T	54785423	3	4	250	1	0	0	0	0	1	0	0	0	7908	536	19	1	2881	1	ITIH5L	23	54785423	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	5945667	54785423	100485137	104	17955											
ZXDA	7789	broad.mit.edu	37	chrX	57936065	57936065	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggcacaggtacagcaccaCgcctggaccagagcccagca	13	15	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:57936065C>T	uc004dve.2	-	1	1003	c.790G>A	c.(790-792)GTG>ATG	p.V264M		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	264					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TACAGCACCACGCCTGGACCA	0.726													T	57936065	T	T	57936065	3	4	250	1	0	0	0	0	1	0	0	0	18247	536	19	1	1613	1	ZXDA	23	57936065	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	3150642	57936065	97334495	105	17956											
TAF1	6872	broad.mit.edu	37	chrX	70613222	70613222	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acagaacaggctcgttctggAgaggggcccatgagtaaatt	13	8	1	3			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:70613222A>C	uc004dzu.3	+	21	3171	c.3120A>C	c.(3118-3120)GGA>GGC	p.G1040G	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Silent_p.G1061G|TAF1_uc004dzv.3_Silent_p.G214G	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1040					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				CTCGTTCTGGAGAGGGGCCCA	0.448													C	70613222	C	C	70613222	2	2	250	1	0	0	0	0	0	0	0	1	15510	291	11	5		5	TAF1	23	70613222	Silent	SNP	A	TCGA-41-5651-01A-01D-1696-08	12677157	70613222	84657338	106	17957											
ABCB7	22	broad.mit.edu	37	chrX	74291376	74291376	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctgactggcgagcaccattAtagctgttaaaccgacactg	9	12	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:74291376A>T	uc004eca.2	-	9	1200	c.1175T>A	c.(1174-1176)ATA>AAA	p.I392K	ABCB7_uc004ebz.2_Missense_Mutation_p.I393K|ABCB7_uc011mqn.1_Missense_Mutation_p.I366K|ABCB7_uc010nls.2_Missense_Mutation_p.I353K|ABCB7_uc010nlt.2_Missense_Mutation_p.I352K	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	392	ABC transmembrane type-1.|Helical; (Potential).				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						GAGCACCATTATAGCTGTTAA	0.388													T	74291376	T	T	74291376	3	4	250	1	0	0	0	0	1	0	0	0	46	449	16	5	1115	5	ABCB7	23	74291376	Missense_Mutation	SNP	A	TCGA-41-5651-01A-01D-1696-08	3678154	74291376	80979184	107	17958											
RPL36A	6173	broad.mit.edu	37	chrX	100646453	100646453	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtttctttactaggttaacGtccctaaaacccgccggact	7	12	1	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:100646453G>A	uc004ehk.2	+	2	94	c.10G>A	c.(10-12)GTC>ATC	p.V4I	BTK_uc010nno.2_5'Flank|RPL36A_uc004ehj.1_Missense_Mutation_p.V4I	NM_021029	NP_066357	P83881	RL36A_HUMAN	ribosomal protein L36a	4					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						CTAGGTTAACGTCCCTAAAAC	0.498													A	100646453	A	A	100646453	3	1	250	1	0	0	0	0	1	0	0	0	13587	1145	40	1	16	1	RPL36A	23	100646453	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	26355077	100646453	54624107	108	17959											
KIAA1210	57481	broad.mit.edu	37	chrX	118238988	118238988	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaactcttatgtggtaaagcCttcttttgtggattcttagg	9	6	3	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:118238988C>A	uc004era.3	-	7	1035	c.1035G>T	c.(1033-1035)AAG>AAT	p.K345N		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	345										ovary(4)|skin(1)	5						GTGGTAAAGCCTTCTTTTGTG	0.418													A	118238988	A	A	118238988	3	1	250	1	0	0	0	0	1	0	0	0	8214	680	24	5	4126	5	KIAA1210	23	118238988	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	17592535	118238988	37031572	109	17960											
FRMD7	90167	broad.mit.edu	37	chrX	131219611	131219611	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaggaaagagattttacccGtaacaccagtactcccatgt	7	10	0	1			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:131219611G>A	uc004ewn.2	-	7	821	c.643C>T	c.(643-645)CGG>TGG	p.R215W	FRMD7_uc011muy.1_Missense_Mutation_p.R200W	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	215	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GATTTTACCCGTAACACCAGT	0.512													A	131219611	A	A	131219611	3	1	250	1	0	0	0	0	1	0	0	0	6055	1144	40	1	1525	1	FRMD7	23	131219611	Missense_Mutation	SNP	G	TCGA-41-5651-01A-01D-1696-08	12980623	131219611	24050949	110	17961											
ATP2B3	492	broad.mit.edu	37	chrX	152818620	152818620	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaccatctgcatcgcctacCgggacttctctgcaggccag	10	16	2	0			TCGA-41-5651-01A-01D-1696-08	TCGA-41-5651-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	5fd77ba9-5015-4d8b-86a0-582e5c76bdd6	54c65bdd-ac2e-466a-80cb-6f534095f56b	g.chrX:152818620C>T	uc004fht.1	+	11	2077	c.1951C>T	c.(1951-1953)CGG>TGG	p.R651W	ATP2B3_uc004fhs.1_Missense_Mutation_p.R651W	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	651	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CATCGCCTACCGGGACTTCTC	0.632													T	152818620	T	T	152818620	3	4	250	1	0	0	0	0	1	0	0	0	1141	643	23	2	1993	2	ATP2B3	23	152818620	Missense_Mutation	SNP	C	TCGA-41-5651-01A-01D-1696-08	21599009	152818620	2451940	111	17962											
CYP4X1	260293	broad.mit.edu	37	chr1	47498961	47498961	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagtggttccagcatcgtcGcctactaactcctggattcc	8	14	0	0	rs116257861	by1000genomes	TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr1:47498961G>A	uc001cqt.2	+	4	663	c.413G>A	c.(412-414)CGC>CAC	p.R138H	CYP4X1_uc001cqr.2_Missense_Mutation_p.R137H|CYP4X1_uc001cqs.2_Missense_Mutation_p.R73H	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	138						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						CAGCATCGTCGCCTACTAACT	0.428													A	47498961	A	A	47498961	3	1	251	1	0	0	0	0	1	0	0	0	4193	1087	38	1	427	1	CYP4X1	1	47498961	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08		47498961	201751660	1	17963											
CREB3L4	148327	broad.mit.edu	37	chr1	153941905	153941905	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctgcccagagcaggcaccGtagccccagtgccctgtaca	10	17	0	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr1:153941905G>A	uc001fdn.3	+	4	783	c.517G>A	c.(517-519)GTA>ATA	p.V173I	SLC39A1_uc001fdl.2_5'Flank|CREB3L4_uc010pef.1_Missense_Mutation_p.V26I|CREB3L4_uc001fdo.3_Missense_Mutation_p.V153I|CREB3L4_uc001fdm.1_Missense_Mutation_p.V173I|CREB3L4_uc001fdp.1_Missense_Mutation_p.V153I|CREB3L4_uc010peg.1_3'UTR|CREB3L4_uc001fdr.2_Missense_Mutation_p.V173I|CREB3L4_uc001fdq.2_Missense_Mutation_p.V153I	NM_130898	NP_570968	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like	173	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AGCAGGCACCGTAGCCCCAGT	0.532													A	153941905	A	A	153941905	3	1	251	1	0	0	0	0	1	0	0	0	3859	1145	40	1	527	1	CREB3L4	1	153941905	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	106442944	153941905	95308716	2	17964											
TOR1AIP1	26092	broad.mit.edu	37	chr1	179886766	179886766	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttaagaataagtaccaaggtCaagatgagaagctgtggaaa	11	4	1	3			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr1:179886766C>T	uc001gnq.2	+	10	1362	c.1144C>T	c.(1144-1146)CAA>TAA	p.Q382*		NM_015602	NP_056417	Q5JTV8	TOIP1_HUMAN	lamina-associated polypeptide 1B	382	Lumenal (Potential).|Potential.					integral to membrane|nuclear inner membrane				breast(1)|central_nervous_system(1)	2						GTACCAAGGTCAAGATGAGAA	0.443													T	179886766	T	T	179886766	4	4	251	1	0	0	0	0	0	1	0	0	16369	827	29	3	1182	3	TOR1AIP1	1	179886766	Nonsense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08	25944861	179886766	69363855	3	17965											
LAMC1	3915	broad.mit.edu	37	chr1	183087214	183087214	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggaggcctgctcttaccccTtttgaatttcagaagctcct	8	12	2	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr1:183087214T>C	uc001gpy.3	+	11	2180	c.1923T>C	c.(1921-1923)CCT>CCC	p.P641P		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	641	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCTTACCCCTTTTGAATTTC	0.418													C	183087214	C	C	183087214	2	2	251	1	0	0	0	0	0	0	0	1	8614	1596	56	4		4	LAMC1	1	183087214	Silent	SNP	T	TCGA-41-6646-01A-11D-1845-08	3200448	183087214	66163407	4	17966											
PPFIA4	8497	broad.mit.edu	37	chr1	203014509	203014509	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggaggaggatacgggccGggtagaggagctgcaggagc	20	8	0	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr1:203014509G>A	uc009xaj.2	+	11	1121	c.1121G>A	c.(1120-1122)CGG>CAG	p.R374Q	PPFIA4_uc010pqf.1_5'UTR			O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						GATACGGGCCGGGTAGAGGAG	0.602													A	203014509	A	A	203014509	3	1	251	1	0	0	0	0	1	0	0	0	12312	1131	39	2		2	PPFIA4	1	203014509	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	19927295	203014509	46236112	5	17967											
ELK4	2005	broad.mit.edu	37	chr1	205589407	205589407	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cctgcaaagggggtatggacGaaatgggtggtgtggtggca	19	5	0	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr1:205589407G>A	uc001hcy.1	-	3	2017	c.767C>T	c.(766-768)TCG>TTG	p.S256L	ELK4_uc001hcz.2_Missense_Mutation_p.S256L	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	256						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GGGTATGGACGAAATGGGTGG	0.522			T	SLC45A3	prostate								A	205589407	A	A	205589407	3	1	251	1	0	0	0	0	1	0	0	0	5061	1059	37	2	678	2	ELK4	1	205589407	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	2574898	205589407	43661214	6	17968											
MRPL55	128308	broad.mit.edu	37	chr1	228294495	228294495	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtccagaactgtcggtagCgctccacatgcaagtcatca	10	12	2	1	rs145809265		TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr1:228294495C>T	uc001hry.2	-	3	1097	c.353G>A	c.(352-354)CGC>CAC	p.R118H	MRPL55_uc001hrz.3_Missense_Mutation_p.R154H|MRPL55_uc009xex.2_Missense_Mutation_p.R118H|MRPL55_uc001hsa.3_Missense_Mutation_p.R118H|MRPL55_uc001hsb.3_Missense_Mutation_p.R118H|MRPL55_uc001hsc.3_Missense_Mutation_p.R118H|MRPL55_uc001hsd.3_Missense_Mutation_p.R118H|MRPL55_uc001hse.3_Missense_Mutation_p.R118H|MRPL55_uc001hsf.3_Missense_Mutation_p.R118H|MRPL55_uc001hsg.3_Missense_Mutation_p.R118H	NM_181465	NP_852130	Q7Z7F7	RM55_HUMAN	mitochondrial ribosomal protein L55 isoform a	118					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			central_nervous_system(1)	1		Prostate(94;0.0405)				CTGTCGGTAGCGCTCCACATG	0.592													T	228294495	T	T	228294495	3	4	251	1	0	0	0	0	1	0	0	0	9819	768	27	1	37	1	MRPL55	1	228294495	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08	22705088	228294495	20956126	7	17969											
RYR2	6262	broad.mit.edu	37	chr1	237632437	237632437	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaactgtgctcaattttctgGctccctcgactggttgatca	8	11	3	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr1:237632437G>A	uc001hyl.1	+	17	1778	c.1658G>A	c.(1657-1659)GGC>GAC	p.G553D		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	553	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAATTTTCTGGCTCCCTCGAC	0.373													A	237632437	A	A	237632437	3	1	251	1	0	0	0	0	1	0	0	0	13769	1203	42	3	1724	3	RYR2	1	237632437	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	9337942	237632437	11618184	8	17970											
OR2T11	127077	broad.mit.edu	37	chr1	248789661	248789661	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggaaggactggggcagcaCgtatgtgtagaaggcagccc	17	8	0	1	rs139227153	byFrequency	TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr1:248789661C>T	uc001ier.1	-	1	769	c.769G>A	c.(769-771)GTG>ATG	p.V257M		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	257	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGGGCAGCACGTATGTGTAG	0.532													T	248789661	T	T	248789661	3	4	251	1	0	0	0	0	1	0	0	0	11018	536	19	1	185	1	OR2T11	1	248789661	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08	11157224	248789661	460960	9	17971											
NPHP1	4867	broad.mit.edu	37	chr2	110922207	110922207	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacagtctccatcctatttcGcatcagaactattaggtagc	6	12	2	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr2:110922207G>A	uc002tfn.3	-	8	923	c.829C>T	c.(829-831)CGA>TGA	p.R277*	NPHP1_uc002tfm.3_Intron|NPHP1_uc002tfl.3_Nonsense_Mutation_p.R277*|NPHP1_uc002tfo.3_Intron|NPHP1_uc010ywx.1_Intron|NPHP1_uc010fjv.1_Intron	NM_207181	NP_997064	O15259	NPHP1_HUMAN	nephrocystin 1 isoform 2	277					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2						ATCCTATTTCGCATCAGAACT	0.458													A	110922207	A	A	110922207	4	1	251	1	0	0	0	0	0	1	0	0	10579	1095	38	1	1424	1	NPHP1	2	110922207	Nonsense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08		110922207	132277166	10	17972											
NCKAP5	344148	broad.mit.edu	37	chr2	133547632	133547632	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcccatcgtgccacgtgtaGgaggagccactggagtactc	12	12	0	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr2:133547632G>A	uc002ttp.2	-	13	1430	c.1056C>T	c.(1054-1056)TCC>TCT	p.S352S	NCKAP5_uc002ttq.2_Silent_p.S352S	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	352	Ser-rich.						protein binding				0						GCCACGTGTAGGAGGAGCCAC	0.522													A	133547632	A	A	133547632	2	1	251	1	0	0	0	0	0	0	0	1	10223	987	35	3		3	NCKAP5	2	133547632	Silent	SNP	G	TCGA-41-6646-01A-11D-1845-08	22625425	133547632	109651741	11	17973											
ITGA6	3655	broad.mit.edu	37	chr2	173356005	173356005	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcccgctgcgggggctggaCagcaaggcgtctcttatttt	14	11	1	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr2:173356005C>T	uc002uhp.1	+	22	3038	c.2835C>T	c.(2833-2835)GAC>GAT	p.D945D	ITGA6_uc010zdy.1_Silent_p.D826D|ITGA6_uc002uho.1_Silent_p.D945D|ITGA6_uc010fqm.1_Silent_p.D576D	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	984	Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			GGGGGCTGGACAGCAAGGCGT	0.473													T	173356005	T	T	173356005	2	4	251	1	0	0	0	0	0	0	0	1	7880	477	17	3		3	ITGA6	2	173356005	Silent	SNP	C	TCGA-41-6646-01A-11D-1845-08	39808373	173356005	69843368	12	17974											
PLCL1	5334	broad.mit.edu	37	chr2	198950624	198950624	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacctgagctggccatgatcCgttttgttgttctggatgat	11	8	1	3			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr2:198950624C>T	uc010fsp.2	+	2	2674	c.2383C>T	c.(2383-2385)CGT>TGT	p.R795C	PLCL1_uc002uuv.3_Missense_Mutation_p.R716C	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	795	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	GGCCATGATCCGTTTTGTTGT	0.398													T	198950624	T	T	198950624	3	4	251	1	0	0	0	0	1	0	0	0	12039	652	23	2	2389	2	PLCL1	2	198950624	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08	25594619	198950624	44248749	13	17975											
EPHA3	2042	broad.mit.edu	37	chr3	89478302	89478302	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tacatggagaatggttccttGgatagtttcctacgtgtaag	11	6	0	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr3:89478302G>A	uc003dqy.2	+	12	2346	c.2121G>A	c.(2119-2121)TTG>TTA	p.L707L	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	707	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATGGTTCCTTGGATAGTTTCC	0.323										TSP Lung(6;0.00050)			A	89478302	A	A	89478302	2	1	251	1	0	0	0	0	0	0	0	1	5168	1339	47	3		3	EPHA3	3	89478302	Silent	SNP	G	TCGA-41-6646-01A-11D-1845-08		89478302	108544128	14	17976											
PTTG2	10744	broad.mit.edu	37	chr4	37962337	37962337	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttctgccaaaaagatgacCgagaagactgttaaaacaaa	7	7	1	4			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr4:37962337C>T	uc011bye.1	+	1	282	c.282C>T	c.(280-282)ACC>ACT	p.T94T	TBC1D1_uc003gtb.2_Intron|TBC1D1_uc011byd.1_Intron|TBC1D1_uc010ifd.2_Intron	NM_006607	NP_006598	Q9NZH5	PTTG2_HUMAN	pituitary tumor-transforming 2	94					chromosome organization|DNA metabolic process	cytoplasm|nucleus	SH3 domain binding				0						AAAAGATGACCGAGAAGACTG	0.403													T	37962337	T	T	37962337	2	4	251	1	0	0	0	0	0	0	0	1	12821	639	23	2		2	PTTG2	4	37962337	Silent	SNP	C	TCGA-41-6646-01A-11D-1845-08		37962337	153191939	15	17977											
SHROOM3	57619	broad.mit.edu	37	chr4	77661478	77661478	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctcgggagccatctggacCggcaggtttcctacccgcgg	13	15	1	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr4:77661478C>T	uc011cbx.1	+	5	3105	c.2152C>T	c.(2152-2154)CGG>TGG	p.R718W	SHROOM3_uc011cbz.1_Missense_Mutation_p.R542W|SHROOM3_uc003hkf.1_Missense_Mutation_p.R593W|SHROOM3_uc003hkg.2_Missense_Mutation_p.R496W	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	718					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CCATCTGGACCGGCAGGTTTC	0.677													T	77661478	T	T	77661478	3	4	251	1	0	0	0	0	1	0	0	0	14295	643	23	2	2170	2	SHROOM3	4	77661478	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08	39699141	77661478	113492798	16	17978											
HNRPDL	9987	broad.mit.edu	37	chr4	83348672	83348672	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtgataaaacaaaatcctcTtctttcatttgtttttgtat	4	6	3	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr4:83348672T>C	uc003hmr.2	-	4	1355	c.820A>G	c.(820-822)AGA>GGA	p.R274G	HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.R274G	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	274	RRM 2.				regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				CAAAATCCTCTTCTTTCATTT	0.333													C	83348672	C	C	83348672	3	2	251	1	0	0	0	0	1	0	0	0	7276	1617	56	4	458	4	HNRPDL	4	83348672	Missense_Mutation	SNP	T	TCGA-41-6646-01A-11D-1845-08	5687194	83348672	107805604	17	17979											
CLGN	1047	broad.mit.edu	37	chr4	141313760	141313760	+	Frame_Shift_Del	DEL	A	-	-													ctttacttttcttggccaacAaaatgaagtaattaatgcta							TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr4:141313760delA	uc011chi.1	-	13	1689	c.1471delT	c.(1471-1473)TGTfs	p.C491fs	CLGN_uc003iii.2_Frame_Shift_Del_p.C491fs	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	491	Helical; (Potential).				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					CTTGGCCAACAAAATGAAGTA	0.348													-	141313760	-	-	141313760	7	5	251	1	0	1	0	1	0	0	0	0	3524	130	5	0	377	0	CLGN	4	141313760	Frame_Shift_Del	DEL	A	TCGA-41-6646-01A-11D-1845-08	57965088	141313760	49840516	18	17980											
FGG	2266	broad.mit.edu	37	chr4	155533209	155533209	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aggattataagtgagttggaTtgcttttatcagctgtttga	11	3	1	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr4:155533209T>C	uc003ioj.2	-	3	409	c.268A>G	c.(268-270)ATC>GTC	p.I90V	FGG_uc003iog.2_Missense_Mutation_p.I90V|FGG_uc003ioh.2_Missense_Mutation_p.I90V|FGG_uc010ipx.2_5'UTR|FGG_uc010ipy.2_Intron|FGG_uc003ioi.2_5'Flank|FGG_uc003iok.2_Missense_Mutation_p.I90V	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	90					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GTGAGTTGGATTGCTTTTATC	0.313													C	155533209	C	C	155533209	3	2	251	1	0	0	0	0	1	0	0	0	5870	1493	52	4	1140	4	FGG	4	155533209	Missense_Mutation	SNP	T	TCGA-41-6646-01A-11D-1845-08	14219449	155533209	35621067	19	17981											
SPOCK3	50859	broad.mit.edu	37	chr4	168155201	168155201	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gattgtggtgagccattgttTatcatccagaaaattaccgc	9	8	1	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr4:168155201T>A	uc003iri.1	-	2	265	c.124A>T	c.(124-126)AAA>TAA	p.K42*	SPOCK3_uc011cjp.1_Nonsense_Mutation_p.K42*|SPOCK3_uc011cjq.1_Nonsense_Mutation_p.K54*|SPOCK3_uc011cjr.1_5'UTR|SPOCK3_uc003irj.1_Nonsense_Mutation_p.K42*|SPOCK3_uc011cjs.1_5'UTR|SPOCK3_uc011cjt.1_5'UTR|SPOCK3_uc011cju.1_5'UTR|SPOCK3_uc011cjv.1_Nonsense_Mutation_p.K42*|SPOCK3_uc003irk.3_Nonsense_Mutation_p.K42*|SPOCK3_uc011cjw.1_RNA	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	42					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		AGCCATTGTTTATCATCCAGA	0.597													A	168155201	A	A	168155201	4	1	251	1	0	0	0	0	0	1	0	0	15080	1763	61	5	1230	5	SPOCK3	4	168155201	Nonsense_Mutation	SNP	T	TCGA-41-6646-01A-11D-1845-08	12621992	168155201	22999075	20	17982											
C5orf33	133686	broad.mit.edu	37	chr5	36195277	36195279	+	In_Frame_Del	DEL	TCT	-	-													gaagcacagttcgaagctcaTcttctttattgatcatcatc							TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr5:36195277_36195279delTCT	uc003jkf.3	-	12	1296_1298	c.1296_1298delAGA	c.(1294-1299)GAAGAT>GAT	p.E432del	C5orf33_uc003jke.3_RNA|C5orf33_uc010iux.2_In_Frame_Del_p.E237del|C5orf33_uc003jkg.3_In_Frame_Del_p.E269del|C5orf33_uc011cov.1_In_Frame_Del_p.E291del	NM_001085411	NP_001078880	Q4G0N4	NAKD1_HUMAN	hypothetical protein LOC133686 isoform 1	432							NAD+ kinase activity				0	all_lung(31;5.63e-05)		Epithelial(62;0.0254)|all cancers(62;0.0805)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCGAAGCTCATCTTCTTTATTGA	0.399													-	36195279	-	-	36195277	7	5	251	1	0	1	0	1	0	0	0	0	2292	1435	50	0	34	0	C5orf33	5	36195277	In_Frame_Del	DEL	TCT	TCGA-41-6646-01A-11D-1845-08		36195277	144719983	21	17983											
ATOX1	475	broad.mit.edu	37	chr5	151131276	151131276	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcactcacctccaagcttaTtgaggacccgagagacagct	8	14	2	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr5:151131276T>C	uc003luk.2	-	2	169	c.71A>G	c.(70-72)AAT>AGT	p.N24S		NM_004045	NP_004036	O00244	ATOX1_HUMAN	antioxidant protein 1	24	HMA.				cellular copper ion homeostasis|copper ion transport|response to oxidative stress	cytosol	copper chaperone activity|copper-dependent protein binding				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			TCCAAGCTTATTGAGGACCCG	0.527													C	151131276	C	C	151131276	3	2	251	1	0	0	0	0	1	0	0	0	1115	1493	52	4	143	4	ATOX1	5	151131276	Missense_Mutation	SNP	T	TCGA-41-6646-01A-11D-1845-08	114935999	151131276	29783984	22	17984											
CSNK2B	1460	broad.mit.edu	37	chr6	31637272	31637272	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccaagagacctgccaacCagtttgtgcccaggtaggga	13	12	0	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr6:31637272C>T	uc003nvr.1	+	6	884	c.544C>T	c.(544-546)CAG>TAG	p.Q182*	CSNK2B_uc003nvs.1_Nonsense_Mutation_p.Q182*|LY6G5B_uc003nvt.1_5'Flank	NM_001320	NP_001311	P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	182					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding				0						ACCTGCCAACCAGTTTGTGCC	0.572													T	31637272	T	T	31637272	4	4	251	1	0	0	0	0	0	1	0	0	3959	595	21	3	562	3	CSNK2B	6	31637272	Nonsense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08		31637272	139477795	23	17985											
UNC5CL	222643	broad.mit.edu	37	chr6	40996200	40996200	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgccgtgtgtcccactcaggTagttctggatggcggaggcg	16	11	2	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr6:40996200T>C	uc003opi.2	-	9	1558	c.1469A>G	c.(1468-1470)TAC>TGC	p.Y490C		NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	490	Death.|Cytoplasmic (Potential).				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCCACTCAGGTAGTTCTGGAT	0.667											OREG0017423	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	40996200	C	C	40996200	3	2	251	1	0	0	0	0	1	0	0	0	16991	1638	57	4	91	4	UNC5CL	6	40996200	Missense_Mutation	SNP	T	TCGA-41-6646-01A-11D-1845-08	9358928	40996200	130118867	24	17986											
TRERF1	55809	broad.mit.edu	37	chr6	42231242	42231242	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagggagctgtggtggcggcGgaggcggaggcggaggcggc	26	7	0	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr6:42231242G>A	uc003osd.2	-	8	2263	c.1700C>T	c.(1699-1701)CCG>CTG	p.P567L	TRERF1_uc011duq.1_Intron|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Missense_Mutation_p.P567L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	567	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding	p.P567P(1)		ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			tggtggcggcggaggcggagg	0.383													A	42231242	A	A	42231242	3	1	251	1	0	0	0	0	1	0	0	0	16472	1116	39	2	1946	2	TRERF1	6	42231242	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	1235042	42231242	128883825	25	17987											
EIF3B	8662	broad.mit.edu	37	chr7	2412424	2412424	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aaaacaacgggaagattgaaCtcatcagtaagtaacctggt	9	7	2	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr7:2412424C>G	uc003slx.2	+	12	1887	c.1804C>G	c.(1804-1806)CTC>GTC	p.L602V	EIF3B_uc003sly.2_Missense_Mutation_p.L602V|EIF3B_uc003sma.2_Missense_Mutation_p.L330V	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	602					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		GAAGATTGAACTCATCAGTAA	0.507													G	2412424	G	G	2412424	3	3	251	1	0	0	0	0	1	0	0	0	5013	565	20	5	1850	5	EIF3B	7	2412424	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08		2412424	156726239	26	17988											
GAL3ST4	79690	broad.mit.edu	37	chr7	99764391	99764391	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cggaagggctggtcgtagggAtggggccgagggctgtcgga	22	7	0	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr7:99764391A>T	uc003utt.2	-	2	1180	c.163T>A	c.(163-165)TCC>ACC	p.S55T	GAL3ST4_uc003utu.2_Missense_Mutation_p.S55T|GAL3ST4_uc010lgq.2_Intron	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	55	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGTCGTAGGGATGGGGCCGAG	0.622													T	99764391	T	T	99764391	3	4	251	1	0	0	0	0	1	0	0	0	6200	333	12	5	1305	5	GAL3ST4	7	99764391	Missense_Mutation	SNP	A	TCGA-41-6646-01A-11D-1845-08	97351967	99764391	59374272	27	17989											
DOCK4	9732	broad.mit.edu	37	chr7	111540437	111540437	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accaaacacttactggaacaAtgccgaaactcgaagcggat	8	11	0	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr7:111540437A>C	uc003vfx.2	-	15	1742	c.1473T>G	c.(1471-1473)CAT>CAG	p.H491Q	DOCK4_uc003vfy.2_Missense_Mutation_p.H491Q|DOCK4_uc003vga.1_Missense_Mutation_p.H96Q	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	491	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TACTGGAACAATGCCGAAACT	0.473													C	111540437	C	C	111540437	3	2	251	1	0	0	0	0	1	0	0	0	4689	98	4	5	4579	5	DOCK4	7	111540437	Missense_Mutation	SNP	A	TCGA-41-6646-01A-11D-1845-08	11776046	111540437	47598226	28	17990											
DLGAP2	9228	broad.mit.edu	37	chr8	1581155	1581155	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccggctactcccaagatgacGaatgtattcccatgatgaca	8	12	0	4			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr8:1581155G>A	uc003wpl.2	+	5	1610	c.1513G>A	c.(1513-1515)GAA>AAA	p.E505K	DLGAP2_uc003wpm.2_Missense_Mutation_p.E505K	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	584					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CCAAGATGACGAATGTATTCC	0.547													A	1581155	A	A	1581155	3	1	251	1	0	0	0	0	1	0	0	0	4560	1059	37	2	1527	2	DLGAP2	8	1581155	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08		1581155	144782867	29	17991											
NUDCD1	84955	broad.mit.edu	37	chr8	110308796	110308796	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cgtggttttcctaaggcagtGtcctaaaaagaccaaacatt	8	9	0	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr8:110308796G>C	uc003ynb.3	-	3	387	c.276C>G	c.(274-276)GAC>GAG	p.D92E	NUDCD1_uc003yna.2_Missense_Mutation_p.D63E|NUDCD1_uc010mcl.2_Missense_Mutation_p.D5E|NUDCD1_uc010mcm.1_Missense_Mutation_p.D5E	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	92										ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			CTAAGGCAGTGTCCTAAAAAG	0.378													C	110308796	C	C	110308796	3	2	251	1	0	0	0	0	1	0	0	0	10722	1368	48	5	1507	5	NUDCD1	8	110308796	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	108727641	110308796	36055226	30	17992											
C9orf103	414328	broad.mit.edu	37	chr9	86258531	86258531	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtttgaggtcatctctggaCgcttactcaaaagagaggga	12	8	3	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr9:86258531C>T	uc004amu.1	+	5	414	c.400C>T	c.(400-402)CGC>TGC	p.R134C	C9orf103_uc004amt.1_Missense_Mutation_p.R88C|C9orf103_uc010mpv.1_Missense_Mutation_p.R88C	NM_001001551	NP_001001551	Q5T6J7	GNTK_HUMAN	gluconokinase-like protein	134					carbohydrate metabolic process	cytoplasm	ATP binding|gluconokinase activity|shikimate kinase activity				0						CATCTCTGGACGCTTACTCAA	0.507													T	86258531	T	T	86258531	3	4	251	1	0	0	0	0	1	0	0	0	2446	536	19	1	272	1	C9orf103	9	86258531	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08		86258531	54954900	31	17993											
C9orf5	23731	broad.mit.edu	37	chr9	111822726	111822726	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caccttatctcctagaatttTatggagctagaaaaaaacac	5	9	1	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr9:111822726T>A	uc004bdt.3	-	11	1662	c.1630A>T	c.(1630-1632)AAA>TAA	p.K544*	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Nonsense_Mutation_p.K536*	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	544						integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		CCTAGAATTTTATGGAGCTAG	0.343													A	111822726	A	A	111822726	4	1	251	1	0	0	0	0	0	1	0	0	2486	1763	61	5	1041	5	C9orf5	9	111822726	Nonsense_Mutation	SNP	T	TCGA-41-6646-01A-11D-1845-08	25564195	111822726	29390705	32	17994											
NEBL	10529	broad.mit.edu	37	chr10	21185902	21185902	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttacatcgctaatgagttcCgtgcattttctggccaattc	7	11	1	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr10:21185902C>T	uc001iqi.2	-	2	535	c.138G>A	c.(136-138)ACG>ACA	p.T46T	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	46	Nebulin 1.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TAATGAGTTCCGTGCATTTTC	0.294													T	21185902	T	T	21185902	2	4	251	1	0	0	0	0	0	0	0	1	10303	639	23	2		2	NEBL	10	21185902	Silent	SNP	C	TCGA-41-6646-01A-11D-1845-08		21185902	114348845	33	17995											
OR52E2	119678	broad.mit.edu	37	chr11	5080175	5080175	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcttcatgagtaggaagaCggaaaacagcacaaagaata	12	6	1	3	rs141087990		TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr11:5080175C>T	uc010qyw.1	-	1	683	c.683G>A	c.(682-684)CGT>CAT	p.R228H		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		AGTAGGAAGACGGAAAACAGC	0.398													T	5080175	T	T	5080175	3	4	251	1	0	0	0	0	1	0	0	0	11115	536	19	1	297	1	OR52E2	11	5080175	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08		5080175	129926341	34	17996											
OR5W2	390148	broad.mit.edu	37	chr11	55681607	55681607	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaaagcatctgctattcccAccagataaaccccagtcaag	5	14	3	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr11:55681607A>G	uc010rir.1	-	1	452	c.452T>C	c.(451-453)GTG>GCG	p.V151A		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGCTATTCCCACCAGATAAAC	0.458													G	55681607	G	G	55681607	3	3	251	1	0	0	0	0	1	0	0	0	11185	159	6	4	482	4	OR5W2	11	55681607	Missense_Mutation	SNP	A	TCGA-41-6646-01A-11D-1845-08	50601432	55681607	79324909	35	17997											
GLYATL1	92292	broad.mit.edu	37	chr11	58722269	58722269	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	actgatgacatggattcataCacaaacgtatatcgtatgtt	7	7	1	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr11:58722269C>A	uc001nnf.2	+	6	589	c.213C>A	c.(211-213)TAC>TAA	p.Y71*	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Nonsense_Mutation_p.Y102*|GLYATL1_uc001nni.1_Nonsense_Mutation_p.Y71*|GLYATL1_uc001nnj.1_Nonsense_Mutation_p.Y71*			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	71						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	TGGATTCATACACAAACGTAT	0.373													A	58722269	A	A	58722269	4	1	251	1	0	0	0	0	0	1	0	0	6480	489	17	5	324	5	GLYATL1	11	58722269	Nonsense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08	3040662	58722269	76284247	36	17998											
NPAS4	266743	broad.mit.edu	37	chr11	66192332	66192332	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagctgaggctggcactggCggactagagccacttggagg	16	10	1	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr11:66192332C>T	uc001ohx.1	+	7	2147	c.1971C>T	c.(1969-1971)GGC>GGT	p.G657G	NPAS4_uc010rpc.1_Silent_p.G447G	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	657					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CTGGCACTGGCGGACTAGAGC	0.582													T	66192332	T	T	66192332	2	4	251	1	0	0	0	0	0	0	0	1	10565	755	27	1		1	NPAS4	11	66192332	Silent	SNP	C	TCGA-41-6646-01A-11D-1845-08	7470063	66192332	68814184	37	17999											
ARHGEF17	9828	broad.mit.edu	37	chr11	73020926	73020926	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggttctgggggctggggcGtgtaccgctcccctagcttt	17	11	1	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr11:73020926G>A	uc001otu.2	+	1	1264	c.1243G>A	c.(1243-1245)GTG>ATG	p.V415M		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	415					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GGGCTGGGGCGTGTACCGCTC	0.657													A	73020926	A	A	73020926	3	1	251	1	0	0	0	0	1	0	0	0	900	1145	40	1	1245	1	ARHGEF17	11	73020926	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	6828594	73020926	61985590	38	18000											
RECQL	5965	broad.mit.edu	37	chr12	21643134	21643134	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taatttttttagtacataccAtctgaacataatgctggtaa	5	6	1	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr12:21643134A>G	uc001rex.2	-	5	741	c.393T>C	c.(391-393)GAT>GAC	p.D131D	RECQL_uc001rey.2_Silent_p.D131D	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	131	Helicase ATP-binding.				DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						AGTACATACCATCTGAACATA	0.274								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					G	21643134	G	G	21643134	2	3	251	1	0	0	0	0	0	0	0	1	13201	231	8	4		4	RECQL	12	21643134	Silent	SNP	A	TCGA-41-6646-01A-11D-1845-08		21643134	112208761	39	18001											
MPHOSPH9	10198	broad.mit.edu	37	chr12	123661241	123661241	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaaataacttacttggcaCgcgagggtctcacgtgaatt	10	8	1	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr12:123661241C>T	uc001uel.2	-	12	2101	c.1994G>A	c.(1993-1995)CGT>CAT	p.R665H	MPHOSPH9_uc010tal.1_Missense_Mutation_p.R119H|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Missense_Mutation_p.R119H	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	665					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		TTACTTGGCACGCGAGGGTCT	0.353													T	123661241	T	T	123661241	3	4	251	1	0	0	0	0	1	0	0	0	9728	536	19	1	1137	1	MPHOSPH9	12	123661241	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08	102018107	123661241	10190654	40	18002											
UGGT2	55757	broad.mit.edu	37	chr13	96578002	96578002	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aaaatctgcaataatccagaGagtgactgcagaaattatac	7	7	1	3			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr13:96578002G>A	uc001vmt.2	-	20	2397	c.2227C>T	c.(2227-2229)CTC>TTC	p.L743F		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	743					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						ATAATCCAGAGAGTGACTGCA	0.303													A	96578002	A	A	96578002	3	1	251	1	0	0	0	0	1	0	0	0	16939	942	33	3	2403	3	UGGT2	13	96578002	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08		96578002	18591876	41	18003											
SLC38A6	145389	broad.mit.edu	37	chr14	61518523	61518525	+	In_Frame_Del	DEL	ATG	-	-													aggccagaaaagctgtaacaAtgatgtttttctccaatttt							TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr14:61518523_61518525delATG	uc001xfg.1	+	14	1185_1187	c.1069_1071delATG	c.(1069-1071)ATGdel	p.M358del	SLC38A6_uc001xfh.1_In_Frame_Del_p.M358del|SLC38A6_uc001xfi.2_RNA|SLC38A6_uc001xfj.1_RNA|SLC38A6_uc001xfk.2_RNA|SLC38A6_uc010trz.1_In_Frame_Del_p.M335del	NM_153811	NP_722518	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	358					amino acid transport|sodium ion transport	integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		AGCTGTAACAATGATGTTTTTCT	0.34													-	61518525	-	-	61518523	7	5	251	1	0	1	0	1	0	0	0	0	14608	101	4	0	1123	0	SLC38A6	14	61518523	In_Frame_Del	DEL	ATG	TCGA-41-6646-01A-11D-1845-08		61518523	45831017	42	18004											
SERPINA11	256394	broad.mit.edu	37	chr14	94912695	94912695	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ggagcaattggccccattttCtcagggtctgtggctgcaga	13	10	2	1	rs148183767		TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr14:94912695C>G	uc001ydd.1	-	3	950	c.890G>C	c.(889-891)AGA>ACA	p.R297T		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	297					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		GCCCCATTTTCTCAGGGTCTG	0.562													G	94912695	G	G	94912695	3	3	251	1	0	0	0	0	1	0	0	0	14088	913	32	5	390	5	SERPINA11	14	94912695	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08	33394172	94912695	12436845	43	18005											
TRPM1	4308	broad.mit.edu	37	chr15	31360288	31360288	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttggtgtcataggatacaCggatatactgtgaaagagtg	13	5	1	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr15:31360288C>T	uc001zfm.2	-	4	349	c.221G>A	c.(220-222)CGT>CAT	p.R74H	TRPM1_uc010azy.2_Translation_Start_Site|TRPM1_uc001zfl.2_RNA|uc010ubm.1_5'Flank|MIR211_hsa-mir-211|MI0000287_5'Flank|uc010ubn.1_5'Flank	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	74	Extracellular (Potential).		R -> C (in CSNB1C).		cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		ATAGGATACACGGATATACTG	0.493													T	31360288	T	T	31360288	3	4	251	1	0	0	0	0	1	0	0	0	16582	536	19	1	4686	1	TRPM1	15	31360288	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08		31360288	71171104	44	18006											
COX10	1352	broad.mit.edu	37	chr17	14110443	14110443	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cggagactgttcttctgcagCctgtggcacctgccgctgct	12	14	2	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr17:14110443C>A	uc002gof.3	+	7	1449	c.1245C>A	c.(1243-1245)AGC>AGA	p.S415R	COX10_uc010vvs.1_Missense_Mutation_p.S198R|COX10_uc010vvt.1_Missense_Mutation_p.S223R	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	415	Helical; (Potential).				heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		TCTTCTGCAGCCTGTGGCACC	0.657													A	14110443	A	A	14110443	3	1	251	1	0	0	0	0	1	0	0	0	3762	738	26	5	1271	5	COX10	17	14110443	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08		14110443	67084767	45	18007											
NF1	4763	broad.mit.edu	37	chr17	29654691	29654691	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccgctcaccttcatgcacCaggagtgtgaagccattgtc	10	14	2	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr17:29654691C>T	uc002hgg.2	+	38	5776	c.5443C>T	c.(5443-5445)CAG>TAG	p.Q1815*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q1794*|NF1_uc002hgi.1_Nonsense_Mutation_p.Q827*|NF1_uc010cso.2_Nonsense_Mutation_p.Q3*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1815					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.Q1815*(1)|p.H1814fs*43(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTTCATGCACCAGGAGTGTGA	0.493			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29654691	T	T	29654691	4	4	251	1	0	0	0	0	0	1	0	0	10356	595	21	3	5654	3	NF1	17	29654691	Nonsense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08	15544248	29654691	51540519	46	18008											
ABHD3	171586	broad.mit.edu	37	chr18	19283692	19283692	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgaaactctcacccccgGtcactaactggggtttctga	10	13	3	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr18:19283692G>A	uc002ktl.2	-	2	319	c.179C>T	c.(178-180)ACC>ATC	p.T60I	ABHD3_uc002ktm.2_Missense_Mutation_p.T60I|ABHD3_uc010xao.1_Intron|MIB1_uc002ktp.2_5'Flank|ABHD3_uc002kto.2_Missense_Mutation_p.T60I	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	60						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1						CTCACCCCCGGTCACTAACTG	0.547													A	19283692	A	A	19283692	3	1	251	1	0	0	0	0	1	0	0	0	83	1261	44	3	1082	3	ABHD3	18	19283692	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08		19283692	58793556	47	18009											
PIK3R2	5296	broad.mit.edu	37	chr19	18280055	18280055	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcgctcaccgtcaccctggCgcacccagtgcgcgccccgg	12	21	2	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr19:18280055C>T	uc002nia.1	+	16	2650	c.2138C>T	c.(2137-2139)GCG>GTG	p.A713V	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	713	SH2 2.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						GTCACCCTGGCGCACCCAGTg	0.572													T	18280055	T	T	18280055	3	4	251	1	0	0	0	0	1	0	0	0	11919	768	27	1	2196	1	PIK3R2	19	18280055	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08		18280055	40848928	48	18010											
DHX34	9704	broad.mit.edu	37	chr19	47876058	47876058	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatcgcagccgcacttagcGtccagtcgcccttcacccgc	8	20	1	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr19:47876058G>A	uc010xyn.1	+	8	2181	c.1840G>A	c.(1840-1842)GTC>ATC	p.V614I	DHX34_uc010elc.1_Missense_Mutation_p.V529I	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	614						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CGCACTTAGCGTCCAGTCGCC	0.672													A	47876058	A	A	47876058	3	1	251	1	0	0	0	0	1	0	0	0	4507	1145	40	1	1866	1	DHX34	19	47876058	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	29596003	47876058	11252925	49	18011											
SIGLEC12	89858	broad.mit.edu	37	chr19	52004890	52004890	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacacaggccctcctgcaccGtcacggacttctgcattgtc	8	17	2	0	rs141817270		TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr19:52004890G>A	uc002pwx.1	-	1	154	c.98C>T	c.(97-99)ACG>ATG	p.T33M	SIGLEC12_uc002pww.1_5'Flank|SIGLEC12_uc010eoy.1_Translation_Start_Site	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	33	Ig-like V-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CTCCTGCACCGTCACGGACTT	0.473													A	52004890	A	A	52004890	3	1	251	1	0	0	0	0	1	0	0	0	14308	1145	40	1	1794	1	SIGLEC12	19	52004890	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	4128832	52004890	7124093	50	18012											
ZNF761	388561	broad.mit.edu	37	chr19	53958627	53958627	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcatcccttacatgccatcGtagacttcatactggagaga	8	11	2	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr19:53958627G>A	uc010eqp.2	+	7	1324	c.866G>A	c.(865-867)CGT>CAT	p.R289H	ZNF761_uc010ydy.1_Missense_Mutation_p.R235H|ZNF761_uc002qbt.1_Missense_Mutation_p.R235H	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	289	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ACATGCCATCGTAGACTTCAT	0.398													A	53958627	A	A	53958627	3	1	251	1	0	0	0	0	1	0	0	0	18133	1145	40	1	877	1	ZNF761	19	53958627	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	1953737	53958627	5170356	51	18013											
EPS8L1	54869	broad.mit.edu	37	chr19	55597484	55597484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggacccagcggggcaggaggGatatgtgccctacaacatcc	14	12	0	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr19:55597484G>A	uc002qis.3	+	16	1678	c.1574G>A	c.(1573-1575)GGA>GAA	p.G525E	EPS8L1_uc010ess.1_Missense_Mutation_p.G539E|EPS8L1_uc010yfr.1_Missense_Mutation_p.G461E|EPS8L1_uc002qiu.2_Missense_Mutation_p.G398E|EPS8L1_uc002qiv.2_Missense_Mutation_p.G203E|EPS8L1_uc002qiw.2_Missense_Mutation_p.G304E	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway	525	SH3.					cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GGGCAGGAGGGATATGTGCCC	0.622													A	55597484	A	A	55597484	3	1	251	1	0	0	0	0	1	0	0	0	5195	1174	41	3	1684	3	EPS8L1	19	55597484	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	1638857	55597484	3531499	52	18014											
ZNF831	128611	broad.mit.edu	37	chr20	57767405	57767405	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcagcatcgacctgcccaCgccctacacctacaaggact	9	17	0	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr20:57767405C>T	uc002yan.2	+	1	1331	c.1331C>T	c.(1330-1332)ACG>ATG	p.T444M		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	444						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GACCTGCCCACGCCCTACACC	0.682													T	57767405	T	T	57767405	3	4	251	1	0	0	0	0	1	0	0	0	18182	536	19	1	1333	1	ZNF831	20	57767405	Missense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08		57767405	5258115	53	18015											
TMPRSS15	5651	broad.mit.edu	37	chr21	19687506	19687506	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcacagtgcagatgaccGtcacagagattcaccagtgg	10	12	3	3	rs148711749	byFrequency	TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr21:19687506G>A	uc002ykw.2	-	17	2020	c.1989C>T	c.(1987-1989)GAC>GAT	p.D663D		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	663	Extracellular (Potential).|LDL-receptor class A 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						GCAGATGACCGTCACAGAGAT	0.398													A	19687506	A	A	19687506	2	1	251	1	0	0	0	0	0	0	0	1	16243	1136	40	1		1	TMPRSS15	21	19687506	Silent	SNP	G	TCGA-41-6646-01A-11D-1845-08		19687506	28442389	54	18016											
SLC5A1	6523	broad.mit.edu	37	chr22	32445981	32445981	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggcttcttcctggcaggcCgaagtatggtgtggtggccg	17	9	1	0			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr22:32445981C>T	uc003amc.2	+	2	419	c.187C>T	c.(187-189)CGA>TGA	p.R63*		NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	63	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						CCTGGCAGGCCGAAGTATGGT	0.448													T	32445981	T	T	32445981	4	4	251	1	0	0	0	0	0	1	0	0	14661	644	23	2	193	2	SLC5A1	22	32445981	Nonsense_Mutation	SNP	C	TCGA-41-6646-01A-11D-1845-08		32445981	18858585	55	18017											
CARD10	29775	broad.mit.edu	37	chr22	37906263	37906263	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcagtgacgccgtcagccGctggttctcagcacgcagct	12	16	2	1			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chr22:37906263G>A	uc003asx.1	-	4	868	c.865C>T	c.(865-867)CGG>TGG	p.R289W	CARD10_uc003ast.1_RNA|CARD10_uc003asw.1_5'Flank|CARD10_uc003asy.1_Missense_Mutation_p.R289W	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	289	Potential.				activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					GCCGTCAGCCGCTGGTTCTCA	0.572													A	37906263	A	A	37906263	3	1	251	1	0	0	0	0	1	0	0	0	2644	1086	38	1	2301	1	CARD10	22	37906263	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08	5460282	37906263	13398303	56	18018											
CXorf22	170063	broad.mit.edu	37	chrX	35985796	35985796	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcaaagacttggcaaaacGcaagaattatgcacctgtag	10	8	1	2			TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chrX:35985796G>A	uc004ddj.2	+	10	1720	c.1661G>A	c.(1660-1662)CGC>CAC	p.R554H	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	554								p.R554R(1)		large_intestine(1)|lung(1)|ovary(1)	3						TTGGCAAAACGCAAGAATTAT	0.393													A	35985796	A	A	35985796	3	1	251	1	0	0	0	0	1	0	0	0	4102	1087	38	1	1699	1	CXorf22	23	35985796	Missense_Mutation	SNP	G	TCGA-41-6646-01A-11D-1845-08		35985796	119284764	57	18019											
PCDH19	57526	broad.mit.edu	37	chrX	99662130	99662131	+	Frame_Shift_Del	DEL	GA	-	-													gcgacggcacgatctggtagGagacactgccgttgagaccc							TCGA-41-6646-01A-11D-1845-08	TCGA-41-6646-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6272bb0c-c47b-4cd2-9f59-398f1a75f020	2f6c3ea0-2797-4863-9a77-a6b67964b3a4	g.chrX:99662130_99662131delGA	uc010nmz.2	-	1	3141_3142	c.1465_1466delTC	c.(1465-1467)TCCfs	p.S489fs	PCDH19_uc004efw.3_Frame_Shift_Del_p.S489fs|PCDH19_uc004efx.3_Frame_Shift_Del_p.S489fs	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	489	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GATCTGGTAGGAGACACTGCCG	0.584													-	99662131	-	-	99662130	7	5	251	1	0	1	0	1	0	0	0	0	11514	1174	41	0	2004	0	PCDH19	23	99662130	Frame_Shift_Del	DEL	GA	TCGA-41-6646-01A-11D-1845-08	63676334	99662130	55608430	58	18020											
CROCC	9696	broad.mit.edu	37	chr1	17281847	17281847	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgcgtctgctggaggatgCccgtgacgggctgcggcggg	20	11	1	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr1:17281847C>T	uc001azt.2	+	24	3575	c.3506C>T	c.(3505-3507)GCC>GTC	p.A1169V	CROCC_uc001azu.2_Missense_Mutation_p.A472V	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1169	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CTGGAGGATGCCCGTGACGGG	0.711													T	17281847	T	T	17281847	3	4	252	1	0	0	0	0	1	0	0	0	3893	739	26	3	3600	3	CROCC	1	17281847	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08		17281847	231968774	1	18021											
GLIS1	148979	broad.mit.edu	37	chr1	54060541	54060541	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagtggccagcgggccccgaCagtgggcagacagggatgtg	18	11	0	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr1:54060541C>A	uc001cvr.1	-	3	602	c.35G>T	c.(34-36)TGT>TTT	p.C12F		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	12					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						CGGGCCCCGACAGTGGGCAGA	0.657													A	54060541	A	A	54060541	3	1	252	1	0	0	0	0	1	0	0	0	6445	478	17	5	1859	5	GLIS1	1	54060541	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08	36778694	54060541	195190080	2	18022											
RSBN1	54665	broad.mit.edu	37	chr1	114354435	114354435	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	caggagctgggatcaccatcGgggccgcggtggtgatggtg	19	9	1	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr1:114354435G>C	uc001edq.2	-	1	636	c.600C>G	c.(598-600)CCC>CCG	p.P200P	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	200						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATCACCATCGGGGCCGCGGT	0.637													C	114354435	C	C	114354435	2	2	252	1	0	0	0	0	0	0	0	1	13696	1103	39	5		5	RSBN1	1	114354435	Silent	SNP	G	TCGA-74-6573-01A-12D-1845-08	60293894	114354435	134896186	3	18023											
F5	2153	broad.mit.edu	37	chr1	169510453	169510453	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgagttctggagagaggtttGtctggctgaagtctagagaa	15	4	3	4			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr1:169510453G>A	uc001ggg.1	-	13	4020	c.3875C>T	c.(3874-3876)ACA>ATA	p.T1292I		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1292	2-12.|B.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AGAGAGGTTTGTCTGGCTGAA	0.522													A	169510453	A	A	169510453	3	1	252	1	0	0	0	0	1	0	0	0	5348	1377	48	3	2851	3	F5	1	169510453	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	55156018	169510453	79740168	4	18024											
OR2T10	127069	broad.mit.edu	37	chr1	248756796	248756796	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccacacccaaggaccgagaTggtcttgtctttggccagct	11	13	2	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr1:248756796T>C	uc010pzn.1	-	1	274	c.274A>G	c.(274-276)ATC>GTC	p.I92V		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGACCGAGATGGTCTTGTCT	0.507													C	248756796	C	C	248756796	3	2	252	1	0	0	0	0	1	0	0	0	11017	1464	51	4	667	4	OR2T10	1	248756796	Missense_Mutation	SNP	T	TCGA-74-6573-01A-12D-1845-08	79246343	248756796	493825	5	18025											
C2orf39	92749	broad.mit.edu	37	chr2	26637295	26637295	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caaacagaaagaagaaagccGattggtatgaactggttggc	12	6	0	4	rs148643291	by1000genomes	TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr2:26637295G>A	uc002rhg.2	+	2	313	c.239G>A	c.(238-240)CGA>CAA	p.R80Q	C2orf39_uc010eym.1_RNA	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	80											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAGAAAGCCGATTGGTATGA	0.448													A	26637295	A	A	26637295	3	1	252	1	0	0	0	0	1	0	0	0	2164	1058	37	2	245	2	C2orf39	2	26637295	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08		26637295	216562078	6	18026											
LRP2	4036	broad.mit.edu	37	chr2	170163790	170163790	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaggactaaaacagactcaCggcagtcattctcatcagct	7	12	4	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr2:170163790C>T	uc002ues.2	-	4	640	c.427_splice	c.e4+1	p.Q143_splice	LRP2_uc010zdf.1_Splice_Site_p.Q143_splice	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2						hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AACAGACTCACGGCAGTCATT	0.438													T	170163790	T	T	170163790	5	4	252	1	0	0	0	0	0	0	1	0	8956	550	19	1	13843	1	LRP2	2	170163790	Splice_Site	SNP	C	TCGA-74-6573-01A-12D-1845-08	143526495	170163790	73035583	7	18027											
ICA1L	130026	broad.mit.edu	37	chr2	203650727	203650727	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgattcctcttgggagaccCagtctgggataaaagaagta	11	8	2	3			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr2:203650727C>G	uc002uzh.1	-	13	1411	c.1247G>C	c.(1246-1248)TGG>TCG	p.W416S	ICA1L_uc002uzi.1_Missense_Mutation_p.W416S	NM_138468	NP_612477	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like isoform 1	416											0						TTGGGAGACCCAGTCTGGGAT	0.358													G	203650727	G	G	203650727	3	3	252	1	0	0	0	0	1	0	0	0	7478	595	21	5	209	5	ICA1L	2	203650727	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08	33486937	203650727	39548646	8	18028											
DOCK3	1795	broad.mit.edu	37	chr3	51315131	51315131	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accatcatgagcaaatcgcaCgctcaggaggcggtaagagg	13	10	2	2			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr3:51315131C>T	uc011bds.1	+	26	2792	c.2769C>T	c.(2767-2769)CAC>CAT	p.H923H		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	923						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GCAAATCGCACGCTCAGGAGG	0.552													T	51315131	T	T	51315131	2	4	252	1	0	0	0	0	0	0	0	1	4688	535	19	1		1	DOCK3	3	51315131	Silent	SNP	C	TCGA-74-6573-01A-12D-1845-08		51315131	146707299	9	18029											
FHIT	2272	broad.mit.edu	37	chr3	59999845	59999845	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggacgcaggtcatggaagCgctccactggccgcagcggg	16	13	1	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr3:59999845C>T	uc003dkx.3	-	6	508	c.137G>A	c.(136-138)CGC>CAC	p.R46H	FHIT_uc003dky.2_Missense_Mutation_p.R46H|FHIT_uc010hnn.1_Missense_Mutation_p.R46H	NM_002012	NP_002003	P49789	FHIT_HUMAN	fragile histidine triad gene	46	HIT.				nucleotide metabolic process		bis(5'-adenosyl)-triphosphatase activity|protein binding				0		all_cancers(2;2.37e-314)|all_epithelial(2;5.17e-286)|Colorectal(2;1.24e-68)|all_lung(2;1.31e-45)|Lung NSC(2;1.79e-44)|all_hematologic(2;1.59e-23)|Renal(2;1.03e-13)|Breast(2;1.06e-10)|Esophageal squamous(2;6.31e-09)|Melanoma(2;1.83e-07)|Acute lymphoblastic leukemia(2;5.46e-05)|all_neural(2;0.00118)|Medulloblastoma(2;0.00263)|Hepatocellular(2;0.0245)|Ovarian(2;0.0408)		UCEC - Uterine corpus endometrioid carcinoma (45;0.0887)|Epithelial(1;9.28e-70)|all cancers(1;3.07e-60)|Colorectal(1;2.33e-53)|STAD - Stomach adenocarcinoma(1;7.22e-48)|COAD - Colon adenocarcinoma(3;1.05e-44)|READ - Rectum adenocarcinoma(3;2.41e-08)|KIRC - Kidney renal clear cell carcinoma(10;0.000109)|Kidney(10;0.000125)|Lung(1;0.000161)|LUSC - Lung squamous cell carcinoma(1;0.000742)|OV - Ovarian serous cystadenocarcinoma(275;0.00372)|BRCA - Breast invasive adenocarcinoma(55;0.00448)		GTCATGGAAGCGCTCCACTGG	0.542			T	HMGA2	pleomorphic salivary gland adenoma				Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				T	59999845	T	T	59999845	3	4	252	1	0	0	0	0	1	0	0	0	5877	768	27	1	322	1	FHIT	3	59999845	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08	8684714	59999845	138022585	10	18030											
ZBED2	79413	broad.mit.edu	37	chr3	111312907	111312907	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaccgggtgcccttgttgtGgggcattggagtgggcatag	18	7	0	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr3:111312907G>A	uc003dxy.2	-	2	1027	c.142C>T	c.(142-144)CAC>TAC	p.H48Y	CD96_uc003dxv.2_Intron|CD96_uc003dxw.2_Intron|CD96_uc003dxx.2_Intron|CD96_uc010hpy.1_Intron	NM_024508	NP_078784	Q9BTP6	ZBED2_HUMAN	zinc finger, BED domain containing 2	48							DNA binding|metal ion binding			skin(1)	1						CCCTTGTTGTGGGGCATTGGA	0.552													A	111312907	A	A	111312907	3	1	252	1	0	0	0	0	1	0	0	0	17515	1348	47	3	518	3	ZBED2	3	111312907	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	51313062	111312907	86709523	11	18031											
C3orf15	89876	broad.mit.edu	37	chr3	119462849	119462849	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggttgaaaaccatttggccGgactggaaggaagggcacta	14	7	0	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr3:119462849G>A	uc003ede.3	+	14	1785	c.1708G>A	c.(1708-1710)GGA>AGA	p.G570R	C3orf15_uc010hqz.2_Missense_Mutation_p.G508R|C3orf15_uc011bjd.1_Missense_Mutation_p.G444R|C3orf15_uc011bje.1_Missense_Mutation_p.G550R	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	406	Potential.					mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		CCATTTGGCCGGACTGGAAGG	0.453													A	119462849	A	A	119462849	3	1	252	1	0	0	0	0	1	0	0	0	2209	1117	39	2	1762	2	C3orf15	3	119462849	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	8149942	119462849	78559581	12	18032											
MECOM	2122	broad.mit.edu	37	chr3	168833248	168833248	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagcaggtcttgattcgacGttgcttcctttttttccccc	8	12	1	1	rs140021434		TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr3:168833248G>A	uc003ffi.3	-	7	2117	c.1848C>T	c.(1846-1848)AAC>AAT	p.N616N	MECOM_uc010hwk.1_Silent_p.N639N|MECOM_uc003ffj.3_Silent_p.N681N|MECOM_uc011bpi.1_Silent_p.N617N|MECOM_uc003ffn.3_Silent_p.N616N|MECOM_uc003ffk.2_Silent_p.N616N|MECOM_uc003ffl.2_Silent_p.N776N|MECOM_uc011bpj.1_Silent_p.N804N|MECOM_uc011bpk.1_Silent_p.N606N|MECOM_uc010hwn.2_Silent_p.N804N	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	616					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TTGATTCGACGTTGCTTCCTT	0.488													A	168833248	A	A	168833248	2	1	252	1	0	0	0	0	0	0	0	1	9422	1136	40	1		1	MECOM	3	168833248	Silent	SNP	G	TCGA-74-6573-01A-12D-1845-08	49370399	168833248	29189182	13	18033											
JAKMIP1	152789	broad.mit.edu	37	chr4	6062187	6062187	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtaacttctccaaatcttcGattttggcctgacacctcag	6	12	3	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr4:6062187G>A	uc003giu.3	-	11	1884	c.1608C>T	c.(1606-1608)ATC>ATT	p.I536I	JAKMIP1_uc010idb.1_Silent_p.I536I|JAKMIP1_uc010idc.1_Silent_p.I351I|JAKMIP1_uc010idd.1_Intron|JAKMIP1_uc011bwc.1_Silent_p.I371I|JAKMIP1_uc003giv.3_Silent_p.I536I|JAKMIP1_uc010ide.2_Silent_p.I536I	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	536	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CCAAATCTTCGATTTTGGCCT	0.532													A	6062187	A	A	6062187	2	1	252	1	0	0	0	0	0	0	0	1	7940	1048	37	2		2	JAKMIP1	4	6062187	Silent	SNP	G	TCGA-74-6573-01A-12D-1845-08		6062187	185092089	14	18034											
ABLIM2	84448	broad.mit.edu	37	chr4	8089918	8089918	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggaggccctgggacaggtgCgcgctgctgcccaccgatac	15	15	0	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr4:8089918C>T	uc003gko.2	-	4	575	c.432G>A	c.(430-432)GCG>GCA	p.A144A	ABLIM2_uc003gkj.3_Silent_p.A144A|ABLIM2_uc003gkm.3_Silent_p.A144A|ABLIM2_uc003gkp.2_Silent_p.A144A|ABLIM2_uc003gkq.2_Silent_p.A144A|ABLIM2_uc003gkr.2_Silent_p.A144A|ABLIM2_uc003gks.3_Silent_p.A144A|ABLIM2_uc011bwl.1_Silent_p.A149A	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	144					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3						GGGACAGGTGCGCGCTGCTGC	0.632													T	8089918	T	T	8089918	2	4	252	1	0	0	0	0	0	0	0	1	95	755	27	1		1	ABLIM2	4	8089918	Silent	SNP	C	TCGA-74-6573-01A-12D-1845-08	2027731	8089918	183064358	15	18035											
SORBS2	8470	broad.mit.edu	37	chr4	186545046	186545046	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttcgaattcggagatgcGtgtgggcaccatgtcccggg	14	10	0	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr4:186545046G>A	uc003iyl.2	-	13	2383	c.1525C>T	c.(1525-1527)CGC>TGC	p.R509C	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.R609C|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.R413C|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.R623C|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	509						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TCGGAGATGCGTGTGGGCACC	0.572													A	186545046	A	A	186545046	3	1	252	1	0	0	0	0	1	0	0	0	14928	1145	40	1	1813	1	SORBS2	4	186545046	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	178455128	186545046	4609230	16	18036											
PIK3R1	5295	broad.mit.edu	37	chr5	67589601	67589602	+	In_Frame_Ins	INS	-	GTT	GTT													ttacatgaatataacactcaINSgtttcaagaaaaaagtcgag							TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr5:67589601_67589602insGTT	uc003jva.2	+	11	1924_1925	c.1364_1365insGTT	c.(1363-1365)CAG>CAGTTG	p.455_456insL	PIK3R1_uc003jvb.2_In_Frame_Ins_p.455_456insL|PIK3R1_uc003jvc.2_In_Frame_Ins_p.155_156insL|PIK3R1_uc003jvd.2_In_Frame_Ins_p.185_186insL|PIK3R1_uc003jve.2_In_Frame_Ins_p.134_135insL|PIK3R1_uc011crb.1_In_Frame_Ins_p.125_126insL	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	455_456					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.T454_Q455>Q(1)|p.Y452_Q455>SGGSRIK(1)|p.?(1)|p.F456_R461del(1)|p.T454_D464del(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TATAACACTCAGTTTCAAGAAA	0.287			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			GTT	67589602	GTT	GTT	67589601	7	5	252	1	0	1	1	0	0	0	0	0	11918	188	7	0	1532	0	PIK3R1	5	67589601	In_Frame_Ins	INS	-	TCGA-74-6573-01A-12D-1845-08		67589601	113325659	17	18037											
TMEM174	134288	broad.mit.edu	37	chr5	72469563	72469563	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtctgtggtgagcccctgcGgcctcataacctctggaggg	14	12	3	1	rs138671212		TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr5:72469563G>A	uc010izc.2	+	1	541	c.493G>A	c.(493-495)GGC>AGC	p.G165S		NM_153217	NP_694949	Q8WUU8	TM174_HUMAN	transmembrane protein 174	165						integral to membrane				ovary(1)	1		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		GAGCCCCTGCGGCCTCATAAC	0.547													A	72469563	A	A	72469563	3	1	252	1	0	0	0	0	1	0	0	0	16087	1116	39	2	495	2	TMEM174	5	72469563	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	4879962	72469563	108445697	18	18038											
HTR4	3360	broad.mit.edu	37	chr5	147830788	147830788	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attctgggtcattgtgtatgGgcagtttctcgagttcctga	12	7	3	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr5:147830788G>A	uc003lpj.1	-	7	1288	c.1124C>T	c.(1123-1125)CCC>CTC	p.P375L	HTR4_uc010jgu.1_RNA|HTR4_uc003lpi.1_3'UTR	NM_001040169	NP_001035259	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform a	Error:Variant_position_missing_in_Q13639_after_alignment					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	ATTGTGTATGGGCAGTTTCTC	0.468													A	147830788	A	A	147830788	3	1	252	1	0	0	0	0	1	0	0	0	7449	1232	43	3	43	3	HTR4	5	147830788	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	75361225	147830788	33084472	19	18039											
PDGFRB	5159	broad.mit.edu	37	chr5	149501489	149501489	+	Silent	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gccatgtagttggaggactcGatgtctgcatatttgacgtc	12	8	1	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr5:149501489G>T	uc003lro.2	-	16	2767	c.2298C>A	c.(2296-2298)ATC>ATA	p.I766I	PDGFRB_uc010jhd.2_Silent_p.I605I	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	766	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TGGAGGACTCGATGTCTGCAT	0.532			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								T	149501489	T	T	149501489	2	4	252	1	0	0	0	0	0	0	0	1	11662	1048	37	5		5	PDGFRB	5	149501489	Silent	SNP	G	TCGA-74-6573-01A-12D-1845-08	1670701	149501489	31413771	20	18040											
KIF13A	63971	broad.mit.edu	37	chr6	17805708	17805708	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	acattttgtctcttttacctCaggaactttttccttccatt	3	11	2	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr6:17805708C>A	uc003ncg.3	-	19	2407	c.2302G>T	c.(2302-2304)GAG>TAG	p.E768*	KIF13A_uc003ncf.2_Nonsense_Mutation_p.E768*|KIF13A_uc003nch.3_Nonsense_Mutation_p.E768*|KIF13A_uc003nci.3_Nonsense_Mutation_p.E768*	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	768	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TCTTTTACCTCAGGAACTTTT	0.303													A	17805708	A	A	17805708	4	1	252	1	0	0	0	0	0	1	0	0	8274	835	29	5	3224	5	KIF13A	6	17805708	Nonsense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08		17805708	153309359	21	18041											
MPP6	51678	broad.mit.edu	37	chr7	24727093	24727093	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaacagtggatgaaagtgcaCggattcagagagcatacaac	11	7	1	2			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr7:24727093C>T	uc003swx.2	+	13	1782	c.1483C>T	c.(1483-1485)CGG>TGG	p.R495W	MPP6_uc003swy.2_Missense_Mutation_p.R495W|MPP6_uc010kur.2_Missense_Mutation_p.R163W	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	495	Guanylate kinase-like.				protein complex assembly		protein binding				0						TGAAAGTGCACGGATTCAGAG	0.348													T	24727093	T	T	24727093	3	4	252	1	0	0	0	0	1	0	0	0	9738	527	19	1	1525	1	MPP6	7	24727093	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08		24727093	134411570	22	18042											
AOAH	313	broad.mit.edu	37	chr7	36571798	36571798	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgttggaagacatccagccGtggcaggggctgacctgaga	15	9	0	3			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr7:36571798G>A	uc003tfh.3	-	18	1781	c.1380C>T	c.(1378-1380)CAC>CAT	p.H460H	AOAH_uc010kxf.2_Silent_p.H460H|AOAH_uc011kba.1_Silent_p.H428H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	460					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						ACATCCAGCCGTGGCAGGGGC	0.512													A	36571798	A	A	36571798	2	1	252	1	0	0	0	0	0	0	0	1	726	1136	40	1		1	AOAH	7	36571798	Silent	SNP	G	TCGA-74-6573-01A-12D-1845-08	11844705	36571798	122566865	23	18043											
VSTM2A	222008	broad.mit.edu	37	chr7	54617588	54617588	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatttccaaagtgaggaaaaAggatgaaggcttatatgagt	12	3	0	3			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr7:54617588A>G	uc010kzf.2	+	4	764	c.359A>G	c.(358-360)AAG>AGG	p.K120R	VSTM2A_uc010kze.2_Missense_Mutation_p.K120R|VSTM2A_uc003tqc.3_Missense_Mutation_p.K120R	NM_182546	NP_872352	Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2	120	Ig-like V-type.					extracellular region					0			STAD - Stomach adenocarcinoma(5;0.0525)			GTGAGGAAAAAGGATGAAGGC	0.443													G	54617588	G	G	54617588	3	3	252	1	0	0	0	0	1	0	0	0	17226	72	3	4	373	4	VSTM2A	7	54617588	Missense_Mutation	SNP	A	TCGA-74-6573-01A-12D-1845-08	18045790	54617588	104521075	24	18044											
CCT6A	908	broad.mit.edu	37	chr7	56127280	56127280	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tagccctgaattcttttgacGacctaagtcctgactgcttg	8	11	1	3			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr7:56127280G>A	uc003trl.1	+	9	1176	c.1012G>A	c.(1012-1014)GAC>AAC	p.D338N	PSPH_uc003trj.2_Intron|CCT6A_uc003trm.1_Missense_Mutation_p.D293N|CCT6A_uc011kcu.1_Missense_Mutation_p.D307N|SNORA15_uc003trn.1_5'Flank	NM_001762	NP_001753	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A isoform	338					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			upper_aerodigestive_tract(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTCTTTTGACGACCTAAGTCC	0.398													A	56127280	A	A	56127280	3	1	252	1	0	0	0	0	1	0	0	0	2957	1058	37	2	1046	2	CCT6A	7	56127280	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	1509692	56127280	103011383	25	18045											
SUMF2	25870	broad.mit.edu	37	chr7	56141892	56141892	+	Frame_Shift_Del	DEL	A	-	-													actctggtggcttccagtggAaaaggcattttggaggcagg							TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr7:56141892delA	uc003trv.2	+	4	453	c.422delA	c.(421-423)GAAfs	p.E141fs	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Frame_Shift_Del_p.E141fs|SUMF2_uc011kcx.1_Frame_Shift_Del_p.E141fs|SUMF2_uc003trt.2_Frame_Shift_Del_p.E34fs|SUMF2_uc011kcy.1_Intron|SUMF2_uc011kcz.1_Intron|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_Intron|SUMF2_uc003trx.2_Intron	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	122						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTTCCAGTGGAAAAGGCATTT	0.562											OREG0018081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	-	56141892	-	-	56141892	7	5	252	1	0	1	0	1	0	0	0	0	15383	246	9	0	436	0	SUMF2	7	56141892	Frame_Shift_Del	DEL	A	TCGA-74-6573-01A-12D-1845-08	14612	56141892	102996771	26	18046											
OCM2	4951	broad.mit.edu	37	chr7	97617753	97617753	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcttcttcatccagataccCgctctggtcgttgtctatga	7	13	5	2			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr7:97617753C>T	uc003upc.2	-	2	169	c.169G>A	c.(169-171)GGG>AGG	p.G57R		NM_006188	NP_006179	P0CE71	OCM2_HUMAN	oncomodulin-like	57	EF-hand 1.|1 (Potential).						calcium ion binding				0						TCCAGATACCCGCTCTGGTCG	0.537													T	97617753	T	T	97617753	3	4	252	1	0	0	0	0	1	0	0	0	10822	652	23	2	172	2	OCM2	7	97617753	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08	41475861	97617753	61520910	27	18047											
GPC2	221914	broad.mit.edu	37	chr7	99773980	99773980	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcctggggacagacccggaGgtgctcacctggacagagga	15	12	1	2			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr7:99773980G>A	uc003utv.2	-	2	343	c.175C>T	c.(175-177)CTC>TTC	p.L59F	GPC2_uc010lgr.2_RNA|GPC2_uc003utw.1_Missense_Mutation_p.L59F|STAG3_uc010lgs.1_5'Flank|STAG3_uc003utx.1_5'Flank|STAG3_uc011kjk.1_5'Flank	NM_152742	NP_689955	Q8N158	GPC2_HUMAN	glypican 2 precursor	59						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|pancreas(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAGACCCGGAGGTGCTCACCT	0.567													A	99773980	A	A	99773980	3	1	252	1	0	0	0	0	1	0	0	0	6598	1000	35	3	1600	3	GPC2	7	99773980	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	2156227	99773980	59364683	28	18048											
PILRB	29990	broad.mit.edu	37	chr7	99955938	99955938	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acaaggccatgggtcggcccCtgctgctgcccctgctgctc	12	17	0	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr7:99955938C>T	uc003uuk.2	+	15	2509	c.13C>T	c.(13-15)CTG>TTG	p.L5L	PILRB_uc003uul.2_Silent_p.L5L|PILRB_uc003uum.1_RNA|PILRB_uc003uun.2_Silent_p.L5L	NM_013440	NP_038468	Q9UKJ0	PILRB_HUMAN	paired immunoglobulin-like type 2 receptor beta	5					activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGGTCGGCCCCTGCTGCTGCC	0.667													T	99955938	T	T	99955938	2	4	252	1	0	0	0	0	0	0	0	1	11926	680	24	3		3	PILRB	7	99955938	Silent	SNP	C	TCGA-74-6573-01A-12D-1845-08	181958	99955938	59182725	29	18049											
WDR86	349136	broad.mit.edu	37	chr7	151097266	151097266	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacctcctgatggtgcagtcGgcgctgcatgtgaaggcagc	14	12	0	2			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr7:151097266G>A	uc003wkb.2	-	2	674	c.225C>T	c.(223-225)GCC>GCT	p.A75A	WDR86_uc003wka.2_Silent_p.A33A|WDR86_uc011kvk.1_Silent_p.A75A|WDR86_uc003wkc.2_5'UTR	NM_198285	NP_938026	Q86TI4	WDR86_HUMAN	WD repeat domain 86	75	WD 2.										0			OV - Ovarian serous cystadenocarcinoma(82;0.00419)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGTGCAGTCGGCGCTGCATG	0.607													A	151097266	A	A	151097266	2	1	252	1	0	0	0	0	0	0	0	1	17331	1103	39	2		2	WDR86	7	151097266	Silent	SNP	G	TCGA-74-6573-01A-12D-1845-08	51141328	151097266	8041397	30	18050											
PIWIL2	55124	broad.mit.edu	37	chr8	22211836	22211836	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggcagggctgtggcattcctAcgcattatgtctgtgttctc	12	10	2	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr8:22211836A>G	uc003xbn.2	+	22	2858	c.2710A>G	c.(2710-2712)ACG>GCG	p.T904A	PIWIL2_uc011kzf.1_Intron|PIWIL2_uc010ltv.2_Missense_Mutation_p.T904A|PIWIL2_uc003xbo.2_Missense_Mutation_p.T58A	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	904	Piwi.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		TGGCATTCCTACGCATTATGT	0.448													G	22211836	G	G	22211836	3	3	252	1	0	0	0	0	1	0	0	0	11958	391	14	4	2792	4	PIWIL2	8	22211836	Missense_Mutation	SNP	A	TCGA-74-6573-01A-12D-1845-08		22211836	124152186	31	18051											
COL14A1	7373	broad.mit.edu	37	chr8	121160106	121160106	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agattttccagcgcaagatgCggtactggttgcttccacct	10	11	0	2			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr8:121160106C>T	uc003yox.2	+	2	290	c.25C>T	c.(25-27)CGG>TGG	p.R9W		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	9					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCGCAAGATGCGGTACTGGTT	0.423													T	121160106	T	T	121160106	3	4	252	1	0	0	0	0	1	0	0	0	3671	759	27	1	27	1	COL14A1	8	121160106	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08	98948270	121160106	25203916	32	18052											
PTPRD	5789	broad.mit.edu	37	chr9	8341178	8341178	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tacccttgtggattcatatgGcataatattaacaaggcgat	8	7	1	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr9:8341178G>C	uc003zkk.2	-	40	5749	c.5038C>G	c.(5038-5040)CCA>GCA	p.P1680A	PTPRD_uc003zkp.2_Missense_Mutation_p.P1274A|PTPRD_uc003zkq.2_Missense_Mutation_p.P1273A|PTPRD_uc003zkr.2_Missense_Mutation_p.P1264A|PTPRD_uc003zks.2_Missense_Mutation_p.P1273A|PTPRD_uc003zkl.2_Missense_Mutation_p.P1671A|PTPRD_uc003zkm.2_Missense_Mutation_p.P1667A|PTPRD_uc003zkn.2_Missense_Mutation_p.P1269A|PTPRD_uc003zko.2_Missense_Mutation_p.P1270A	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1680	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GATTCATATGGCATAATATTA	0.393										TSP Lung(15;0.13)			C	8341178	C	C	8341178	3	2	252	1	0	0	0	0	1	0	0	0	12799	1203	42	5	724	5	PTPRD	9	8341178	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08		8341178	132872253	33	18053			1	44		2	2	26	G		4.603091e-05
PTPRD	5789	broad.mit.edu	37	chr9	8341203	8341203	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	atattaacaaggcgatttttGaatttattacatggaagatt	7	3	0	2			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr9:8341203G>C	uc003zkk.2	-	40	5724	c.5013C>G	c.(5011-5013)TTC>TTG	p.F1671L	PTPRD_uc003zkp.2_Missense_Mutation_p.F1265L|PTPRD_uc003zkq.2_Missense_Mutation_p.F1264L|PTPRD_uc003zkr.2_Missense_Mutation_p.F1255L|PTPRD_uc003zks.2_Missense_Mutation_p.F1264L|PTPRD_uc003zkl.2_Missense_Mutation_p.F1662L|PTPRD_uc003zkm.2_Missense_Mutation_p.F1658L|PTPRD_uc003zkn.2_Missense_Mutation_p.F1260L|PTPRD_uc003zko.2_Missense_Mutation_p.F1261L	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1671	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGCGATTTTTGAATTTATTAC	0.388										TSP Lung(15;0.13)			C	8341203	C	C	8341203	3	2	252	1	0	0	0	0	1	0	0	0	12799	1281	45	5	749	5	PTPRD	9	8341203	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	25	8341203	132872228	34	18054			1	44		2	2	26	G		4.603091e-05
TRAF1	7185	broad.mit.edu	37	chr9	123673632	123673632	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctggggagaagaggctgaCggtcctgccacaggccgact	15	12	0	3	rs149705933		TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr9:123673632C>T	uc004bku.1	-	6	1437	c.865G>A	c.(865-867)GTC>ATC	p.V289I	TRAF1_uc011lyg.1_Missense_Mutation_p.V167I|TRAF1_uc010mvl.1_Missense_Mutation_p.V289I	NM_005658	NP_005649	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	289	MATH.				apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding	p.V289I(1)		skin(2)|ovary(1)	3						AAGAGGCTGACGGTCCTGCCA	0.612													T	123673632	T	T	123673632	3	4	252	1	0	0	0	0	1	0	0	0	16434	536	19	1	397	1	TRAF1	9	123673632	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08	115332429	123673632	17539799	35	18055											
SLC2A8	29988	broad.mit.edu	37	chr9	130165020	130165020	+	Frame_Shift_Del	DEL	C	-	-													ggctgggaagacccccccatCggggctgagcaggtgagagg							TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr9:130165020delC	uc004bqu.2	+	5	756	c.711delC	c.(709-711)ATCfs	p.I237fs	SLC2A8_uc010mxj.2_Frame_Shift_Del_p.I237fs|SLC2A8_uc004bqv.2_5'Flank	NM_014580	NP_055395	Q9NY64	GTR8_HUMAN	solute carrier family 2 (facilitated glucose	237	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2						ACCCCCCCATCGGGGCTGAGC	0.677													-	130165020	-	-	130165020	7	5	252	1	0	1	0	1	0	0	0	0	14551	874	31	0	729	0	SLC2A8	9	130165020	Frame_Shift_Del	DEL	C	TCGA-74-6573-01A-12D-1845-08	6491388	130165020	11048411	36	18056											
ST8SIA6	338596	broad.mit.edu	37	chr10	17363244	17363244	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atactttgaaagaggtacccGtgttggccctgaaggaaaat	11	7	0	3			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr10:17363244G>A	uc001ipd.2	-	8	830	c.830C>T	c.(829-831)ACG>ATG	p.T277M	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	277	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						AGAGGTACCCGTGTTGGCCCT	0.418													A	17363244	A	A	17363244	3	1	252	1	0	0	0	0	1	0	0	0	15235	1145	40	1	370	1	ST8SIA6	10	17363244	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08		17363244	118171503	37	18057											
OR10A3	26496	broad.mit.edu	37	chr11	7960683	7960683	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatcactgggtagttcagagGatggcaaattgcagcaaatc	11	7	2	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr11:7960683G>A	uc010rbi.1	-	1	385	c.385C>T	c.(385-387)CCT>TCT	p.P129S		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TAGTTCAGAGGATGGCAAATT	0.438													A	7960683	A	A	7960683	3	1	252	1	0	0	0	0	1	0	0	0	10891	1174	41	3	562	3	OR10A3	11	7960683	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08		7960683	127045833	38	18058											
ELP4	26610	broad.mit.edu	37	chr11	31531364	31531364	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcaacctgcggtagtgttgcCgcgagtactgggtctgcagt	15	10	1	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr11:31531364C>G	uc001mtb.2	+	1	68	c.33C>G	c.(31-33)GCC>GCG	p.A11A	IMMP1L_uc001msy.1_5'Flank|IMMP1L_uc001msz.1_5'Flank|ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Silent_p.A11A|ELP4_uc010rdz.1_Silent_p.A11A|IMMP1L_uc009yjo.2_5'Flank|IMMP1L_uc009yjp.2_5'Flank	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	11					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					GTAGTGTTGCCGCGAGTACTG	0.587													G	31531364	G	G	31531364	2	3	252	1	0	0	0	0	0	0	0	1	5082	639	23	5		5	ELP4	11	31531364	Silent	SNP	C	TCGA-74-6573-01A-12D-1845-08	23570681	31531364	103475152	39	18059											
KAT5	10524	broad.mit.edu	37	chr11	65486084	65486084	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgaactctccaaagtggaaGggaaaacagggacccctgag	12	9	1	2			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr11:65486084G>A	uc001ofi.2	+	12	1439	c.1189G>A	c.(1189-1191)GGG>AGG	p.G397R	KAT5_uc001ofj.2_Missense_Mutation_p.G345R|KAT5_uc001ofk.2_Missense_Mutation_p.G430R|KAT5_uc010roo.1_Missense_Mutation_p.G378R|KAT5_uc001ofl.2_Missense_Mutation_p.G186R|RNASEH2C_uc001ofm.2_RNA|RNASEH2C_uc001ofn.2_3'UTR	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	397					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						CAAAGTGGAAGGGAAAACAGG	0.468													A	65486084	A	A	65486084	3	1	252	1	0	0	0	0	1	0	0	0	7983	1000	35	3	1330	3	KAT5	11	65486084	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	33954720	65486084	69520432	40	18060											
KRT75	9119	broad.mit.edu	37	chr12	52824357	52824357	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggactcagcctcggcccGgctgcggttggcaatgtcct	13	15	1	0	rs2232397	byFrequency	TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr12:52824357G>A	uc001saj.2	-	5	1025	c.1003C>T	c.(1003-1005)CGG>TGG	p.R335W		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	335	Coil 2.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		GCCTCGGCCCGGCTGCGGTTG	0.547													A	52824357	A	A	52824357	3	1	252	1	0	0	0	0	1	0	0	0	8488	1115	39	2	672	2	KRT75	12	52824357	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08		52824357	81027538	41	18061											
ACTR6	64431	broad.mit.edu	37	chr12	100601474	100601474	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	atactaatattattatcactGaaccatactttaacttcact	1	9	2	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr12:100601474G>A	uc001thb.1	+	4	345	c.289G>A	c.(289-291)GAA>AAA	p.E97K	ACTR6_uc010svh.1_Missense_Mutation_p.E97K|ACTR6_uc001thc.1_5'UTR|ACTR6_uc001thd.1_Missense_Mutation_p.E97K|ACTR6_uc009ztu.1_5'UTR|ACTR6_uc001the.1_Missense_Mutation_p.E15K|ACTR6_uc001thf.1_Missense_Mutation_p.E15K|uc001thg.1_Intron	NM_022496	NP_071941	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog	97						cytoplasm|cytoskeleton				ovary(1)	1						TATTATCACTGAACCATACTT	0.244													A	100601474	A	A	100601474	3	1	252	1	0	0	0	0	1	0	0	0	216	1291	45	3	303	3	ACTR6	12	100601474	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	47777117	100601474	33250421	42	18062											
SYCP3	50511	broad.mit.edu	37	chr12	102128812	102128812	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcttggcaagaagagccttGttaatgtcaactagattgaa	9	7	2	4			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr12:102128812G>T	uc001tiq.2	-	5	378	c.246C>A	c.(244-246)AAC>AAA	p.N82K	SYCP3_uc001tir.2_Missense_Mutation_p.N82K|SYCP3_uc001tis.2_Missense_Mutation_p.N82K	NM_153694	NP_710161	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	82					cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding				0						GAAGAGCCTTGTTAATGTCAA	0.308													T	102128812	T	T	102128812	3	4	252	1	0	0	0	0	1	0	0	0	15431	1368	48	5	484	5	SYCP3	12	102128812	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	1527338	102128812	31723083	43	18063											
EIF2B1	1967	broad.mit.edu	37	chr12	124111633	124111633	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgtgacgtatacactaaatCgcttcttggccgccacggct	9	13	1	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr12:124111633C>T	uc001ufm.2	-	5	583	c.440G>A	c.(439-441)CGA>CAA	p.R147Q	EIF2B1_uc001ufn.2_Missense_Mutation_p.R147Q|EIF2B1_uc010tat.1_Missense_Mutation_p.R147Q	NM_001414	NP_001405	Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B,	147					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		TACACTAAATCGCTTCTTGGC	0.502													T	124111633	T	T	124111633	3	4	252	1	0	0	0	0	1	0	0	0	5000	884	31	2	497	2	EIF2B1	12	124111633	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08	21982821	124111633	9740262	44	18064											
TMEM62	80021	broad.mit.edu	37	chr15	43476674	43476674	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttttttattctcccctttgCggacctggttgacactgctg	8	12	1	1	rs146146981	byFrequency	TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr15:43476674C>T	uc001zqr.2	+	14	2101	c.1822C>T	c.(1822-1824)CGG>TGG	p.R608W	TMEM62_uc010bda.2_Missense_Mutation_p.R443W|TMEM62_uc001zqt.2_Missense_Mutation_p.R177W|CCNDBP1_uc001zqu.2_5'Flank|CCNDBP1_uc001zqv.2_5'Flank|CCNDBP1_uc010bdc.2_5'Flank|CCNDBP1_uc010bdb.2_5'Flank|CCNDBP1_uc010udl.1_5'Flank|CCNDBP1_uc001zqw.2_5'Flank|CCNDBP1_uc001zqx.2_5'Flank|CCNDBP1_uc010bdd.2_5'Flank|CCNDBP1_uc001zqy.2_5'Flank	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	608	Helical; (Potential).					integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		CTCCCCTTTGCGGACCTGGTT	0.448													T	43476674	T	T	43476674	3	4	252	1	0	0	0	0	1	0	0	0	16186	759	27	1	1876	1	TMEM62	15	43476674	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08		43476674	59054718	45	18065											
MYO5A	4644	broad.mit.edu	37	chr15	52681529	52681529	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatgtgtgttgtacaattttTgggcccaggtgtcatctgtg	12	6	2	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr15:52681529T>G	uc002aby.2	-	13	1818	c.1574A>C	c.(1573-1575)CAA>CCA	p.Q525P	MYO5A_uc002abx.3_Missense_Mutation_p.Q525P|MYO5A_uc010uge.1_Missense_Mutation_p.Q394P	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	525	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GTACAATTTTTGGGCCCAGGT	0.378													G	52681529	G	G	52681529	3	3	252	1	0	0	0	0	1	0	0	0	10078	1812	63	5	4109	5	MYO5A	15	52681529	Missense_Mutation	SNP	T	TCGA-74-6573-01A-12D-1845-08	9204855	52681529	49849863	46	18066											
TMC3	342125	broad.mit.edu	37	chr15	81625404	81625404	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acattcattaatgacatagtAtctgggggcgtggggcctgg	14	7	2	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr15:81625404A>C	uc002bgo.1	-	22	2659	c.2659T>G	c.(2659-2661)TAC>GAC	p.Y887D	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	887	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						ATGACATAGTATCTGGGGGCG	0.473													C	81625404	C	C	81625404	3	2	252	1	0	0	0	0	1	0	0	0	15983	449	16	5	647	5	TMC3	15	81625404	Missense_Mutation	SNP	A	TCGA-74-6573-01A-12D-1845-08	28943875	81625404	20905988	47	18067											
RANBP10	57610	broad.mit.edu	37	chr16	67840366	67840366	+	Frame_Shift_Del	DEL	C	-	-													ccccaggggacggcagcccgCccccagcgcccccgccggag							TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr16:67840366delC	uc002eud.2	-	1	190	c.74delG	c.(73-75)GGCfs	p.G25fs	RANBP10_uc010ceo.2_5'UTR|RANBP10_uc010vju.1_Frame_Shift_Del_p.G25fs|RANBP10_uc010vjv.1_5'UTR|RANBP10_uc010vjx.1_Frame_Shift_Del_p.G25fs|RANBP10_uc010vjy.1_5'UTR|TSNAXIP1_uc010cep.2_5'Flank|TSNAXIP1_uc010vjz.1_5'Flank|TSNAXIP1_uc002euf.3_5'Flank|TSNAXIP1_uc010vka.1_5'Flank|TSNAXIP1_uc010vkb.1_5'Flank|TSNAXIP1_uc002eug.3_5'Flank|TSNAXIP1_uc002euh.3_5'Flank|TSNAXIP1_uc002eui.3_5'Flank|TSNAXIP1_uc002euj.2_5'Flank	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	25										ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		CGGCAGCCCGCCCCCAGCGCC	0.711													-	67840366	-	-	67840366	7	5	252	1	0	1	0	1	0	0	0	0	13026	739	26	0	1844	0	RANBP10	16	67840366	Frame_Shift_Del	DEL	C	TCGA-74-6573-01A-12D-1845-08		67840366	22514387	48	18068											
TP53	7157	broad.mit.edu	37	chr17	7578211	7578211	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agggcaccaccacactatgtCgaaaagtgtttctgtcatcc	8	12	2	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr17:7578211C>T	uc002gim.2	-	6	832	c.638G>A	c.(637-639)CGA>CAA	p.R213Q	TP53_uc002gig.1_Missense_Mutation_p.R213Q|TP53_uc002gih.2_Missense_Mutation_p.R213Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R81Q|TP53_uc010cng.1_Missense_Mutation_p.R81Q|TP53_uc002gii.1_Missense_Mutation_p.R81Q|TP53_uc010cnh.1_Missense_Mutation_p.R213Q|TP53_uc010cni.1_Missense_Mutation_p.R213Q|TP53_uc002gij.2_Missense_Mutation_p.R213Q|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.R120Q|TP53_uc002gio.2_Missense_Mutation_p.R81Q|TP53_uc010vug.1_Missense_Mutation_p.R174Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(182)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACACTATGTCGAAAAGTGTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578211	T	T	7578211	3	4	252	1	0	0	0	0	1	0	0	0	16378	884	31	2	656	2	TP53	17	7578211	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08		7578211	73616999	49	18069											
INSR	3643	broad.mit.edu	37	chr19	7120678	7120678	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatccttcagggactccggTgccatccaccgtacagggag	11	15	1	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr19:7120678T>C	uc002mgd.1	-	20	3721	c.3612A>G	c.(3610-3612)GCA>GCG	p.A1204A	INSR_uc002mge.1_Silent_p.A1192A	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1204	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGGACTCCGGTGCCATCCACC	0.522													C	7120678	C	C	7120678	2	2	252	1	0	0	0	0	0	0	0	1	7773	1683	59	4		4	INSR	19	7120678	Silent	SNP	T	TCGA-74-6573-01A-12D-1845-08		7120678	52008305	50	18070											
PNPLA6	10908	broad.mit.edu	37	chr19	7622102	7622102	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catgacgctgtcgggctaccTgcccccgctgtgcgacccca	11	18	0	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr19:7622102T>C	uc010xjq.1	+	29	3554	c.3359T>C	c.(3358-3360)CTG>CCG	p.L1120P	PNPLA6_uc002mgq.1_Missense_Mutation_p.L1072P|PNPLA6_uc010xjp.1_Missense_Mutation_p.L1045P|PNPLA6_uc002mgr.1_Missense_Mutation_p.L1072P|PNPLA6_uc002mgs.2_Missense_Mutation_p.L1110P|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	1111	Patatin.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						TCGGGCTACCTGCCCCCGCTG	0.662													C	7622102	C	C	7622102	3	2	252	1	0	0	0	0	1	0	0	0	12169	1580	55	4	3469	4	PNPLA6	19	7622102	Missense_Mutation	SNP	T	TCGA-74-6573-01A-12D-1845-08	501424	7622102	51506881	51	18071											
SLC1A6	6511	broad.mit.edu	37	chr19	15061033	15061033	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcactctcgttgcctccccGtccccgggatgcccccttct	8	20	2	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr19:15061033G>A	uc002naa.1	-	9	1677	c.1669C>T	c.(1669-1671)CGG>TGG	p.R557W	SLC1A6_uc010dzu.1_Missense_Mutation_p.R479W|SLC1A6_uc010xod.1_Missense_Mutation_p.R493W	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	557					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	TTGCCTCCCCGTCCCCGGGAT	0.647													A	15061033	A	A	15061033	3	1	252	1	0	0	0	0	1	0	0	0	14436	1144	40	1	29	1	SLC1A6	19	15061033	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	7438931	15061033	44067950	52	18072											
FFAR3	2865	broad.mit.edu	37	chr19	35850547	35850547	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtcgtgggctatatctgcgGtgaaagcccggcgtggagga	17	8	1	1			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr19:35850547G>T	uc002nzd.2	+	2	830	c.755G>T	c.(754-756)GGT>GTT	p.G252V	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	252	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			TATATCTGCGGTGAAAGCCCG	0.607													T	35850547	T	T	35850547	3	4	252	1	0	0	0	0	1	0	0	0	5829	1261	44	5	757	5	FFAR3	19	35850547	Missense_Mutation	SNP	G	TCGA-74-6573-01A-12D-1845-08	20789514	35850547	23278436	53	18073											
DPRX	503834	broad.mit.edu	37	chr19	54140039	54140039	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcctggtgtacacgggtcatCgagtcccctcattccagctc	10	15	2	0	rs150237904		TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr19:54140039C>T	uc002qcf.1	+	3	424	c.373C>T	c.(373-375)CGA>TGA	p.R125*		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	125						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		CACGGGTCATCGAGTCCCCTC	0.567													T	54140039	T	T	54140039	4	4	252	1	0	0	0	0	0	1	0	0	4738	876	31	2	383	2	DPRX	19	54140039	Nonsense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08	18289492	54140039	4988944	54	18074											
C20orf114	92747	broad.mit.edu	37	chr20	31878893	31878893	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccagccatgggagcctgCgcatccaactgctgcataag	10	15	0	0	rs149436006	byFrequency	TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr20:31878893C>T	uc002wyw.1	+	5	657	c.496C>T	c.(496-498)CGC>TGC	p.R166C	C20orf114_uc010gej.1_Missense_Mutation_p.R166C	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	166						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						TGGGAGCCTGCGCATCCAACT	0.507													T	31878893	T	T	31878893	3	4	252	1	0	0	0	0	1	0	0	0	2082	768	27	1	510	1	C20orf114	20	31878893	Missense_Mutation	SNP	C	TCGA-74-6573-01A-12D-1845-08		31878893	31146627	55	18075											
TRIOBP	11078	broad.mit.edu	37	chr22	38120288	38120288	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagccacacgagacaacccCagaacatcctgtgcccagcg	9	16	0	3			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chr22:38120288C>T	uc003atr.2	+	7	1996	c.1725C>T	c.(1723-1725)CCC>CCT	p.P575P	TRIOBP_uc003atu.2_Silent_p.P403P|TRIOBP_uc003atq.1_Silent_p.P575P|TRIOBP_uc003ats.1_Silent_p.P403P	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	575					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GAGACAACCCCAGAACATCCT	0.582													T	38120288	T	T	38120288	2	4	252	1	0	0	0	0	0	0	0	1	16550	581	21	3		3	TRIOBP	22	38120288	Silent	SNP	C	TCGA-74-6573-01A-12D-1845-08		38120288	13184278	56	18076											
SATL1	340562	broad.mit.edu	37	chrX	84363108	84363108	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgcttggttgtttcatgtcCacttggttcatttcatatag	8	7	3	0			TCGA-74-6573-01A-12D-1845-08	TCGA-74-6573-11A-02D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	0941e50e-1205-49ed-8735-1f86eaf87718	32086039-510b-4cae-908d-4a3b4cbf7eba	g.chrX:84363108C>T	uc011mqx.1	-	1	867	c.867G>A	c.(865-867)GTG>GTA	p.V289V	SATL1_uc004een.2_Silent_p.V289V	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	102	Gln-rich.						N-acetyltransferase activity			breast(2)	2						GTTTCATGTCCACTTGGTTCA	0.463													T	84363108	T	T	84363108	2	4	252	1	0	0	0	0	0	0	0	1	13855	581	21	3		3	SATL1	23	84363108	Silent	SNP	C	TCGA-74-6573-01A-12D-1845-08		84363108	70907452	57	18077											
SERINC2	347735	broad.mit.edu	37	chr1	31897702	31897702	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcagcagccgggacccccGggctgccatccagaatgggt	15	14	0	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:31897702G>A	uc010ogh.1	+	3	587	c.386G>A	c.(385-387)CGG>CAG	p.R129Q	SERINC2_uc010ogg.1_Missense_Mutation_p.R126Q|SERINC2_uc009vtw.1_Missense_Mutation_p.R125Q|SERINC2_uc001bst.2_Missense_Mutation_p.R125Q|SERINC2_uc001bsu.2_Missense_Mutation_p.R70Q|SERINC2_uc001bsv.2_Missense_Mutation_p.R70Q	NM_178865	NP_849196	Q96SA4	SERC2_HUMAN	tumor differentially expressed 2-like	125						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)		CGGGACCCCCGGGCTGCCATC	0.647													A	31897702	A	A	31897702	3	1	253	1	0	0	0	0	1	0	0	0	14080	1116	39	2	384	2	SERINC2	1	31897702	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08		31897702	217352919	1	18078											
WLS	79971	broad.mit.edu	37	chr1	68610274	68610274	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gactaacgatgaagaagatgAcagtcatggcagcgcaggcc	13	9	1	4			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:68610274A>G	uc001def.1	-	10	1611	c.1340T>C	c.(1339-1341)GTC>GCC	p.V447A	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Missense_Mutation_p.V445A|WLS_uc001deg.1_Missense_Mutation_p.V356A|WLS_uc009wbf.1_Missense_Mutation_p.V402A	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	447	Helical; Name=6; (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						GAAGAAGATGACAGTCATGGC	0.443													G	68610274	G	G	68610274	3	3	253	1	0	0	0	0	1	0	0	0	17373	275	10	4	423	4	WLS	1	68610274	Missense_Mutation	SNP	A	TCGA-74-6575-01A-11D-1845-08	36712572	68610274	180640347	2	18079											
SLC35A3	23443	broad.mit.edu	37	chr1	100464899	100464899	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acacttaaacttgctattccAtcagggatctatactcttca	4	11	4	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:100464899A>C	uc001dsp.1	+	3	467	c.270A>C	c.(268-270)CCA>CCC	p.P90P	SLC35A3_uc001dsq.1_Silent_p.P90P|SLC35A3_uc009wdy.1_Silent_p.P90P|SLC35A3_uc001dsr.1_Silent_p.P132P|SLC35A3_uc001dss.1_Silent_p.P9P	NM_012243	NP_036375	Q9Y2D2	S35A3_HUMAN	solute carrier family 35 member 3A	90					UDP-N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	sugar:hydrogen symporter activity|UDP-N-acetylglucosamine transmembrane transporter activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.124)|all cancers(265;0.198)|Lung(183;0.199)		TTGCTATTCCATCAGGGATCT	0.308													C	100464899	C	C	100464899	2	2	253	1	0	0	0	0	0	0	0	1	14572	204	8	5		5	SLC35A3	1	100464899	Silent	SNP	A	TCGA-74-6575-01A-11D-1845-08	31854625	100464899	148785722	3	18080											
THEM5	284486	broad.mit.edu	37	chr1	151820732	151820732	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagttttagaaaaggtctcGtccatcatggctgccaggga	12	9	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:151820732G>A	uc009wnd.2	-	4	633	c.501C>T	c.(499-501)GAC>GAT	p.D167D		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	167							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AAAAGGTCTCGTCCATCATGG	0.587													A	151820732	A	A	151820732	2	1	253	1	0	0	0	0	0	0	0	1	15856	1136	40	1		1	THEM5	1	151820732	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	51355833	151820732	97429889	4	18081											
CD1E	913	broad.mit.edu	37	chr1	158325309	158325309	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcttggtcacacctgccctcGatttctagcggggctcatgg	11	13	4	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:158325309G>A	uc001fse.2	+	3	814	c.575G>A	c.(574-576)CGA>CAA	p.R192Q	CD1E_uc010pid.1_Missense_Mutation_p.R190Q|CD1E_uc010pie.1_Missense_Mutation_p.R93Q|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.R192Q|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.R192Q|CD1E_uc001fry.2_Missense_Mutation_p.R192Q|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.R192Q|CD1E_uc009wsv.2_Missense_Mutation_p.R93Q|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	192	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					ACCTGCCCTCGATTTCTAGCG	0.507													A	158325309	A	A	158325309	3	1	253	1	0	0	0	0	1	0	0	0	2978	1058	37	2	585	2	CD1E	1	158325309	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	6504577	158325309	90925312	5	18082											
SPTA1	6708	broad.mit.edu	37	chr1	158621161	158621161	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggagccttagttacctgcCggatttgagctccttctggt	12	10	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:158621161C>T	uc001fst.1	-	24	3672	c.3473G>A	c.(3472-3474)CGG>CAG	p.R1158Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1158	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGTTACCTGCCGGATTTGAGC	0.463													T	158621161	T	T	158621161	3	4	253	1	0	0	0	0	1	0	0	0	15115	652	23	2	3902	2	SPTA1	1	158621161	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	295852	158621161	90629460	6	18083											
SLAMF6	114836	broad.mit.edu	37	chr1	160461161	160461161	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgactgtgattggtaacttGtatgttcctcagttgtcctg	10	8	1	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:160461161G>T	uc001fwe.1	-	3	460	c.400C>A	c.(400-402)CAA>AAA	p.Q134K	SLAMF6_uc001fwd.1_Missense_Mutation_p.Q134K|SLAMF6_uc010pjh.1_Missense_Mutation_p.Q85K|SLAMF6_uc010pji.1_Missense_Mutation_p.Q23K|SLAMF6_uc010pjj.1_Missense_Mutation_p.Q23K|SLAMF6_uc009wtm.1_Missense_Mutation_p.Q85K	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	134	Extracellular (Potential).|Ig-like.					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			TTGGTAACTTGTATGTTCCTC	0.418													T	160461161	T	T	160461161	3	4	253	1	0	0	0	0	1	0	0	0	14368	1386	48	5	622	5	SLAMF6	1	160461161	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	1840000	160461161	88789460	7	18084											
C1orf14	81626	broad.mit.edu	37	chr1	182898838	182898838	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tatagtctttccaaattctcTttttcctttcctacgcctca	2	13	3	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:182898838T>A	uc001gpu.2	-	6	1411	c.1126A>T	c.(1126-1128)AGA>TGA	p.R376*	C1orf14_uc001gpv.2_Nonsense_Mutation_p.R257*|C1orf14_uc010pnz.1_Nonsense_Mutation_p.R234*|C1orf14_uc001gpw.2_Nonsense_Mutation_p.R96*	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	448											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		CCAAATTCTCTTTTTCCTTTC	0.244													A	182898838	A	A	182898838	4	1	253	1	0	0	0	0	0	1	0	0	2000	1617	56	5	855	5	C1orf14	1	182898838	Nonsense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	22437677	182898838	66351783	8	18085											
NCF2	4688	broad.mit.edu	37	chr1	183532621	183532621	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcttagacaccatgtcccGgacctggctgtaggggagcc	12	12	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:183532621G>A	uc001gqj.3	-	12	1401	c.1126C>T	c.(1126-1128)CGG>TGG	p.R376W	NCF2_uc010pod.1_Missense_Mutation_p.R331W|NCF2_uc010poe.1_Missense_Mutation_p.R295W|NCF2_uc001gqk.3_Missense_Mutation_p.R376W	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	376	OPR.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						ACCATGTCCCGGACCTGGCTG	0.567													A	183532621	A	A	183532621	3	1	253	1	0	0	0	0	1	0	0	0	10217	1115	39	2	470	2	NCF2	1	183532621	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	633783	183532621	65718000	9	18086											
CFHR5	81494	broad.mit.edu	37	chr1	196977626	196977626	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcttctttcagatccatgtgTggtatctgaagaaaacatga	8	7	4	4			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:196977626T>C	uc001gts.3	+	10	1651	c.1523T>C	c.(1522-1524)GTG>GCG	p.V508A		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	508	Sushi 9.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GATCCATGTGTGGTATCTGAA	0.289													C	196977626	C	C	196977626	3	2	253	1	0	0	0	0	1	0	0	0	3288	1696	59	4	1561	4	CFHR5	1	196977626	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	13445005	196977626	52272995	10	18087											
USH2A	7399	broad.mit.edu	37	chr1	216498789	216498789	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgggcttcaggattcaacCgtgacactctattatcagct	9	10	4	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:216498789C>T	uc001hku.1	-	6	1388	c.1001G>A	c.(1000-1002)CGG>CAG	p.R334Q	USH2A_uc001hkv.2_Missense_Mutation_p.R334Q	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	334	Laminin N-terminal.|Extracellular (Potential).		R -> Q (in USH2A).|R -> W (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGATTCAACCGTGACACTCT	0.468										HNSCC(13;0.011)			T	216498789	T	T	216498789	3	4	253	1	0	0	0	0	1	0	0	0	17033	652	23	2	14889	2	USH2A	1	216498789	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	19521163	216498789	32751832	11	18088											
OR14A16	284532	broad.mit.edu	37	chr1	247978682	247978682	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tagcagtatagcggtcaaagGacatcaccgtgaggaggagc	14	8	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:247978682G>A	uc001idm.1	-	1	350	c.350C>T	c.(349-351)TCC>TTC	p.S117F		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCGGTCAAAGGACATCACCGT	0.483													A	247978682	A	A	247978682	3	1	253	1	0	0	0	0	1	0	0	0	10945	1174	41	3	583	3	OR14A16	1	247978682	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	31479893	247978682	1271939	12	18089											
OR2L13	284521	broad.mit.edu	37	chr1	248263535	248263535	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttacccccatgctcaatccCattatctacagcctgaggaa	5	15	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr1:248263535C>A	uc001ids.2	+	3	1195	c.858C>A	c.(856-858)CCC>CCA	p.P286P		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TGCTCAATCCCATTATCTACA	0.493													A	248263535	A	A	248263535	2	1	253	1	0	0	0	0	0	0	0	1	11006	581	21	5		5	OR2L13	1	248263535	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	284853	248263535	987086	13	18090											
SOS1	6654	broad.mit.edu	37	chr2	39250170	39250170	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgatttacagcaaatcattaAgccatcaaagagaaatatgt	6	6	2	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr2:39250170A>C	uc002rrk.3	-	10	1440	c.1399T>G	c.(1399-1401)TTA>GTA	p.L467V	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_Missense_Mutation_p.L81V|SOS1_uc002rrl.2_Missense_Mutation_p.L199V	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	467	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				CAAATCATTAAGCCATCAAAG	0.378									Noonan_syndrome				C	39250170	C	C	39250170	3	2	253	1	0	0	0	0	1	0	0	0	14936	69	3	5	2658	5	SOS1	2	39250170	Missense_Mutation	SNP	A	TCGA-74-6575-01A-11D-1845-08		39250170	203949203	14	18091											
TGFA	7039	broad.mit.edu	37	chr2	70742023	70742023	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acgtgctgttctccaaggccTggcacgcagccaacacaata	9	14	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr2:70742023T>C	uc002sgs.3	-	2	268	c.62A>G	c.(61-63)CAG>CGG	p.Q21R	TGFA_uc010fdq.2_Missense_Mutation_p.Q27R|TGFA_uc010fdr.2_Missense_Mutation_p.Q27R|TGFA_uc002sgt.3_Missense_Mutation_p.Q21R|TGFA_uc002sgu.2_Missense_Mutation_p.Q21R|TGFA_uc002sgv.2_Missense_Mutation_p.Q21R|TGFA_uc002sgw.2_Missense_Mutation_p.Q21R	NM_003236	NP_003227	P01135	TGFA_HUMAN	transforming growth factor, alpha isoform 1	21					activation of MAPK activity|cell proliferation|positive regulation of cell division|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	cell surface|extracellular space|integral to membrane|plasma membrane	epidermal growth factor receptor binding|growth factor activity|MAP kinase kinase activity|signal transducer activity			prostate(1)	1						CTCCAAGGCCTGGCACGCAGC	0.607													C	70742023	C	C	70742023	3	2	253	1	0	0	0	0	1	0	0	0	15812	1580	55	4	440	4	TGFA	2	70742023	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	31491853	70742023	172457350	15	18092											
ZNF638	27332	broad.mit.edu	37	chr2	71576267	71576267	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttgctggccatgaatcttaTcagaacatggggccacagag	11	9	2	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr2:71576267T>C	uc002shx.2	+	2	502	c.183T>C	c.(181-183)TAT>TAC	p.Y61Y	ZNF638_uc010fec.2_Silent_p.Y167Y|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Silent_p.Y61Y|ZNF638_uc002shy.2_Silent_p.Y61Y|ZNF638_uc002shz.2_Silent_p.Y61Y|ZNF638_uc002sia.2_Silent_p.Y61Y|ZNF638_uc002sib.1_Silent_p.Y61Y	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	61					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						ATGAATCTTATCAGAACATGG	0.448													C	71576267	C	C	71576267	2	2	253	1	0	0	0	0	0	0	0	1	18052	1442	50	4		4	ZNF638	2	71576267	Silent	SNP	T	TCGA-74-6575-01A-11D-1845-08	834244	71576267	171623106	16	18093											
TTC30A	92104	broad.mit.edu	37	chr2	178481798	178481798	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctatcaccaaattcacaatGcagagatggtacattttccg	6	11	2	1	rs150534803		TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr2:178481798G>A	uc002ulo.2	-	1	1897	c.1632C>T	c.(1630-1632)TGC>TGT	p.C544C		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	544	TPR 8.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			AATTCACAATGCAGAGATGGT	0.383													A	178481798	A	A	178481798	2	1	253	1	0	0	0	0	0	0	0	1	16695	1311	46	3		3	TTC30A	2	178481798	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	106905531	178481798	64717575	17	18094											
TTN	7273	broad.mit.edu	37	chr2	179417389	179417389	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acatgtcttacttatgccagCgtgggaccacgtctgttcac	9	12	3	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr2:179417389C>T	uc010zfg.1	-	284	82758	c.82534G>A	c.(82534-82536)GCT>ACT	p.A27512T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A21207T|TTN_uc010zfi.1_Missense_Mutation_p.A21140T|TTN_uc010zfj.1_Missense_Mutation_p.A21015T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28439							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTATGCCAGCGTGGGACCAC	0.453													T	179417389	T	T	179417389	3	4	253	1	0	0	0	0	1	0	0	0	16732	768	27	1	17853	1	TTN	2	179417389	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	935591	179417389	63781984	18	18095											
TTN	7273	broad.mit.edu	37	chr2	179448529	179448529	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggaagtttgcaagcttctaCgaaatagccaataattttac	7	7	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr2:179448529C>T	uc010zfg.1	-	261	57900	c.57676G>A	c.(57676-57678)GTA>ATA	p.V19226I	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V12921I|TTN_uc010zfi.1_Missense_Mutation_p.V12854I|TTN_uc010zfj.1_Missense_Mutation_p.V12729I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20153							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGCTTCTACGAAATAGCCA	0.463													T	179448529	T	T	179448529	3	4	253	1	0	0	0	0	1	0	0	0	16732	536	19	1	42803	1	TTN	2	179448529	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	31140	179448529	63750844	19	18096											
TTN	7273	broad.mit.edu	37	chr2	179515501	179515501	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctgggggaggagactccgctCtttctggaacaggaacagct	14	10	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr2:179515501C>G	uc010zfg.1	-	163	32608	c.32384G>C	c.(32383-32385)AGA>ACA	p.R10795T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_RNA|TTN_uc002umx.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11722							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGACTCCGCTCTTTCTGGAAC	0.423													G	179515501	G	G	179515501	3	3	253	1	0	0	0	0	1	0	0	0	16732	913	32	5	68201	5	TTN	2	179515501	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	66972	179515501	63683872	20	18097											
KIAA1486	57624	broad.mit.edu	37	chr2	226446762	226446762	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagcacatctttcgatgaaaCgtacatcaaaaagcatgggc	9	9	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr2:226446762C>T	uc002voe.2	+	4	804	c.629C>T	c.(628-630)ACG>ATG	p.T210M	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Translation_Start_Site	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	210										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		TTCGATGAAACGTACATCAAA	0.577													T	226446762	T	T	226446762	3	4	253	1	0	0	0	0	1	0	0	0	8237	536	19	1	639	1	KIAA1486	2	226446762	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	46931261	226446762	16752611	21	18098											
UGT1A4	54657	broad.mit.edu	37	chr2	234628246	234628246	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtggctgttccgaggggaCtttgtgatggactaccccag	15	9	0	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr2:234628246C>T	uc002vux.2	+	1	809	c.780C>T	c.(778-780)GAC>GAT	p.D260D	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Silent_p.D260D	NM_007120	NP_009051	P22310	UD14_HUMAN	UDP glycosyltransferase 1 family, polypeptide A4	260					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)	Imipramine(DB00458)|Lamotrigine(DB00555)|Paricalcitol(DB00910)|Trifluoperazine(DB00831)	TCCGAGGGGACTTTGTGATGG	0.527													T	234628246	T	T	234628246	2	4	253	1	0	0	0	0	0	0	0	1	16944	564	20	3		3	UGT1A4	2	234628246	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	8181484	234628246	8571127	22	18099											
TATDN2	9797	broad.mit.edu	37	chr3	10302000	10302000	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagggcatcctggggaaatcGatgccaaaaaggaagggaga	15	7	0	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:10302000G>A	uc003bvg.2	+	3	1175	c.594G>A	c.(592-594)TCG>TCA	p.S198S	TATDN2_uc003bvf.2_Silent_p.S198S|TATDN2_uc011atr.1_Silent_p.S198S|TATDN2_uc011ats.1_RNA|TATDN2_uc011att.1_RNA	NM_014760	NP_055575	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	198						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			pancreas(2)	2						TGGGGAAATCGATGCCAAAAA	0.557													A	10302000	A	A	10302000	2	1	253	1	0	0	0	0	0	0	0	1	15589	1045	37	2		2	TATDN2	3	10302000	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08		10302000	187720430	23	18100											
BSN	8927	broad.mit.edu	37	chr3	49694511	49694511	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attggcccccccttacacatGcagccttcattgccatggca	7	16	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:49694511G>A	uc003cxe.3	+	5	7636	c.7522G>A	c.(7522-7524)GCA>ACA	p.A2508T		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2508					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCTTACACATGCAGCCTTCAT	0.642													A	49694511	A	A	49694511	3	1	253	1	0	0	0	0	1	0	0	0	1530	1319	46	3	7540	3	BSN	3	49694511	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	39392511	49694511	148327919	24	18101											
RBM6	10180	broad.mit.edu	37	chr3	50099537	50099537	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaaaagacagaggagtgaCgagggtaagaggaattgtta	15	2	0	4			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:50099537C>T	uc003cyc.2	+	15	2715	c.2582C>T	c.(2581-2583)ACG>ATG	p.T861M	RBM6_uc010hlc.1_Missense_Mutation_p.T380M|RBM6_uc003cyd.2_Missense_Mutation_p.T339M|RBM6_uc003cye.2_Missense_Mutation_p.T339M|RBM6_uc011bdi.1_Missense_Mutation_p.T203M|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	861					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		AGAGGAGTGACGAGGGTAAGA	0.378													T	50099537	T	T	50099537	3	4	253	1	0	0	0	0	1	0	0	0	13144	536	19	1	2636	1	RBM6	3	50099537	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	405026	50099537	147922893	25	18102											
RBM15B	29890	broad.mit.edu	37	chr3	51429849	51429850	+	Frame_Shift_Ins	INS	-	A	A													cgggccacgcgcaacctcttINScattggtaacctggaccaca							TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:51429849_51429850insA	uc003dbd.2	+	1	1119_1120	c.1019_1020insA	c.(1018-1020)TTCfs	p.F340fs		NM_013286	NP_037418	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	340	RRM 2.				interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CGCAACCTCTTCATTGGTAACC	0.609													A	51429850	A	A	51429849	7	5	253	1	0	1	1	0	0	0	0	0	13117	1783	62	0	1021	0	RBM15B	3	51429849	Frame_Shift_Ins	INS	-	TCGA-74-6575-01A-11D-1845-08	1330312	51429849	146592581	26	18103											
CADPS	8618	broad.mit.edu	37	chr3	62467450	62467450	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgccgaaaaagtaggcatttGtgggatgcctagagggatgt	15	5	0	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:62467450G>T	uc003dll.2	-	22	3481	c.3121C>A	c.(3121-3123)CAA>AAA	p.Q1041K	CADPS_uc003dlj.1_5'UTR|CADPS_uc003dlk.1_Intron|CADPS_uc003dlm.2_Intron|CADPS_uc003dln.2_Intron	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1041	MHD1.|Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GTAGGCATTTGTGGGATGCCT	0.423													T	62467450	T	T	62467450	3	4	253	1	0	0	0	0	1	0	0	0	2570	1386	48	5	976	5	CADPS	3	62467450	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	11037601	62467450	135554980	27	18104											
ROBO2	6092	broad.mit.edu	37	chr3	77671470	77671470	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttctgatttggaaacggatgTtgcagatgatgatgccgacg	13	6	1	4			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:77671470T>C	uc003dpy.3	+	23	4290	c.3647T>C	c.(3646-3648)GTT>GCT	p.V1216A	ROBO2_uc003dpz.2_Missense_Mutation_p.V1220A|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.V1220A	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1216	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GAAACGGATGTTGCAGATGAT	0.488													C	77671470	C	C	77671470	3	2	253	1	0	0	0	0	1	0	0	0	13514	1725	60	4	3739	4	ROBO2	3	77671470	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	15204020	77671470	120350960	28	18105											
MORC1	27136	broad.mit.edu	37	chr3	108724078	108724078	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttcttttctgtcctctacGgctcgctgaaagctcaaagg	9	11	4	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:108724078G>A	uc003dxl.2	-	19	1939	c.1852C>T	c.(1852-1854)CGT>TGT	p.R618C	MORC1_uc011bhn.1_Missense_Mutation_p.R597C	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	618					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TGTCCTCTACGGCTCGCTGAA	0.363													A	108724078	A	A	108724078	3	1	253	1	0	0	0	0	1	0	0	0	9701	1116	39	2	1142	2	MORC1	3	108724078	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	31052608	108724078	89298352	29	18106											
ECT2	1894	broad.mit.edu	37	chr3	172501613	172501613	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagatttggtaaaaacctacCctccctttgtaaacttcttt	4	10	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:172501613C>G	uc003fii.2	+	15	1687	c.1549C>G	c.(1549-1551)CCT>GCT	p.P517A	ECT2_uc010hwv.1_Missense_Mutation_p.P548A|ECT2_uc003fih.2_Missense_Mutation_p.P516A|ECT2_uc003fij.1_Missense_Mutation_p.P517A|ECT2_uc003fik.1_Missense_Mutation_p.P517A|ECT2_uc003fil.1_Missense_Mutation_p.P548A	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	517	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AAAAACCTACCCTCCCTTTGT	0.308													G	172501613	G	G	172501613	3	3	253	1	0	0	0	0	1	0	0	0	4901	623	22	5	1603	5	ECT2	3	172501613	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	63777535	172501613	25520817	30	18107											
TP63	8626	broad.mit.edu	37	chr3	189582022	189582022	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggccccaactctaagcagtAttccactgaactgaagaaac	7	12	1	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:189582022A>C	uc003fry.2	+	5	670	c.581A>C	c.(580-582)TAT>TCT	p.Y194S	TP63_uc003frx.2_Missense_Mutation_p.Y194S|TP63_uc003frz.2_Missense_Mutation_p.Y194S|TP63_uc010hzc.1_Missense_Mutation_p.Y194S|TP63_uc003fsa.2_Missense_Mutation_p.Y100S|TP63_uc003fsb.2_Missense_Mutation_p.Y100S|TP63_uc003fsc.2_Missense_Mutation_p.Y100S|TP63_uc003fsd.2_Missense_Mutation_p.Y100S|TP63_uc010hzd.1_Missense_Mutation_p.Y15S|TP63_uc003fse.1_Missense_Mutation_p.Y75S	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	194					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TCTAAGCAGTATTCCACTGAA	0.463									Hay-Wells_syndrome	HNSCC(45;0.13)			C	189582022	C	C	189582022	3	2	253	1	0	0	0	0	1	0	0	0	16389	463	16	5	645	5	TP63	3	189582022	Missense_Mutation	SNP	A	TCGA-74-6575-01A-11D-1845-08	17080409	189582022	8440408	31	18108											
CPN2	1370	broad.mit.edu	37	chr3	194062052	194062052	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgccccctgccttgctttcGtccggccacgtgacctggaa	10	17	0	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:194062052G>A	uc003fts.2	-	2	1470	c.1380C>T	c.(1378-1380)GAC>GAT	p.D460D		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	460					protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CCTTGCTTTCGTCCGGCCACG	0.657													A	194062052	A	A	194062052	2	1	253	1	0	0	0	0	0	0	0	1	3810	1136	40	1		1	CPN2	3	194062052	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	4480030	194062052	3960378	32	18109											
ATP13A3	79572	broad.mit.edu	37	chr3	194165469	194165469	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttaccgtgcattttccactCgttgaatcccccaaagatct	5	13	1	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr3:194165469C>T	uc003fty.3	-	14	1946	c.1544G>A	c.(1543-1545)CGA>CAA	p.R515Q	ATP13A3_uc003ftz.1_Missense_Mutation_p.R221Q	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	515					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		ATTTTCCACTCGTTGAATCCC	0.308													T	194165469	T	T	194165469	3	4	253	1	0	0	0	0	1	0	0	0	1125	884	31	2	2212	2	ATP13A3	3	194165469	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	103417	194165469	3856961	33	18110											
FRAS1	80144	broad.mit.edu	37	chr4	79236806	79236806	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cccaggtgtcttacctgtacTgagaagacagtgctgcatga	11	10	1	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr4:79236806T>G	uc003hlb.2	+	16	2177	c.1737T>G	c.(1735-1737)ACT>ACG	p.T579T	FRAS1_uc003hkw.2_Silent_p.T579T|FRAS1_uc003hky.1_Silent_p.T283T|FRAS1_uc003hkz.2_Silent_p.T283T|FRAS1_uc003hla.1_Silent_p.T90T	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	579	FU 4.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TTACCTGTACTGAGAAGACAG	0.517													G	79236806	G	G	79236806	2	3	253	1	0	0	0	0	0	0	0	1	6042	1567	55	5		5	FRAS1	4	79236806	Silent	SNP	T	TCGA-74-6575-01A-11D-1845-08		79236806	111917470	34	18111											
FRAS1	80144	broad.mit.edu	37	chr4	79400786	79400786	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcccgcattggaagggtggCgacagccaaggtgctcatta	14	10	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr4:79400786C>T	uc003hlb.2	+	56	8797	c.8357C>T	c.(8356-8358)GCG>GTG	p.A2786V		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2781	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GGAAGGGTGGCGACAGCCAAG	0.522													T	79400786	T	T	79400786	3	4	253	1	0	0	0	0	1	0	0	0	6042	768	27	1	8654	1	FRAS1	4	79400786	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	163980	79400786	111753490	35	18112											
FHDC1	85462	broad.mit.edu	37	chr4	153881743	153881743	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagttaaaagcgtttagtggCgacgtgtcgaagctgtctct	12	7	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr4:153881743C>T	uc003inf.2	+	4	765	c.690C>T	c.(688-690)GGC>GGT	p.G230G		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	230	FH2.				actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					CGTTTAGTGGCGACGTGTCGA	0.373													T	153881743	T	T	153881743	2	4	253	1	0	0	0	0	0	0	0	1	5876	755	27	1		1	FHDC1	4	153881743	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	74480957	153881743	37272533	36	18113											
TLR3	7098	broad.mit.edu	37	chr4	187003807	187003807	+	Frame_Shift_Del	DEL	A	-	-													actctttgcacgggcttttcAatgtgaggtacctgaatttg							TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr4:187003807delA	uc003iyq.2	+	4	1068	c.967delA	c.(967-969)AATfs	p.N323fs	TLR3_uc011ckz.1_Frame_Shift_Del_p.N46fs|TLR3_uc003iyr.2_Frame_Shift_Del_p.N46fs	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	323	Lumenal (Potential).|LRR 12.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		CGGGCTTTTCAATGTGAGGTA	0.368													-	187003807	-	-	187003807	7	5	253	1	0	1	0	1	0	0	0	0	15949	130	5	0	977	0	TLR3	4	187003807	Frame_Shift_Del	DEL	A	TCGA-74-6575-01A-11D-1845-08	33122064	187003807	4150469	37	18114											
PRDM9	56979	broad.mit.edu	37	chr5	23526688	23526688	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaaagaataatggaagaagaGtccagaacaggccagaaagt	11	5	0	5			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:23526688G>C	uc003jgo.2	+	11	1673	c.1491G>C	c.(1489-1491)GAG>GAC	p.E497D		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	497					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TGGAAGAAGAGTCCAGAACAG	0.453										HNSCC(3;0.000094)			C	23526688	C	C	23526688	3	2	253	1	0	0	0	0	1	0	0	0	12463	1020	36	5	1529	5	PRDM9	5	23526688	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08		23526688	157388572	38	18115											
PRDM9	56979	broad.mit.edu	37	chr5	23526750	23526750	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	attatttgtgggggtaggaaTctcaagaattgcaaaagtca	11	4	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:23526750T>A	uc003jgo.2	+	11	1735	c.1553T>A	c.(1552-1554)ATC>AAC	p.I518N		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	518					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGGGTAGGAATCTCAAGAATT	0.433										HNSCC(3;0.000094)			A	23526750	A	A	23526750	3	1	253	1	0	0	0	0	1	0	0	0	12463	1435	50	5	1591	5	PRDM9	5	23526750	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	62	23526750	157388510	39	18116											
SPEF2	79925	broad.mit.edu	37	chr5	35740247	35740247	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acagaacaagtttccaggagTttctaaagcgtccggatcac	9	10	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:35740247T>A	uc003jjo.2	+	23	3319	c.3208T>A	c.(3208-3210)TTT>ATT	p.F1070I	SPEF2_uc003jjp.1_Missense_Mutation_p.F556I	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1070					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTTCCAGGAGTTTCTAAAGCG	0.388													A	35740247	A	A	35740247	3	1	253	1	0	0	0	0	1	0	0	0	15034	1725	60	5	3319	5	SPEF2	5	35740247	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	12213497	35740247	145175013	40	18117											
UGT3A1	133688	broad.mit.edu	37	chr5	35988627	35988627	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaagaatctgagacacccGgtccaacagtaggtaatggc	11	9	1	3	rs150814543	by1000genomes	TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:35988627G>A	uc003jjv.1	-	2	278	c.121C>T	c.(121-123)CGG>TGG	p.R41W	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.R41W|UGT3A1_uc011cor.1_Intron|UGT3A1_uc003jjy.1_5'UTR	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	41	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGAGACACCCGGTCCAACAGT	0.378													A	35988627	A	A	35988627	3	1	253	1	0	0	0	0	1	0	0	0	16960	1115	39	2	1556	2	UGT3A1	5	35988627	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	248380	35988627	144926633	41	18118											
SLC1A3	6507	broad.mit.edu	37	chr5	36677194	36677194	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tccatgtgcttcggttttgtGattggaaacatgaaggaaca	11	6	0	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:36677194G>C	uc003jkj.3	+	6	1244	c.768G>C	c.(766-768)GTG>GTC	p.V256V	SLC1A3_uc011cox.1_Silent_p.V149V|SLC1A3_uc010iuy.2_Silent_p.V256V	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	256	Helical; (Potential).				D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TCGGTTTTGTGATTGGAAACA	0.473													C	36677194	C	C	36677194	2	2	253	1	0	0	0	0	0	0	0	1	14433	1277	45	5		5	SLC1A3	5	36677194	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	688567	36677194	144238066	42	18119											
PIK3R1	5295	broad.mit.edu	37	chr5	67591259	67591261	+	In_Frame_Del	DEL	AAA	-	-													gtttttcaggtggttgactcAaaaaggtgttcggcaaaaga							TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:67591259_67591261delAAA	uc003jva.2	+	14	2317_2319	c.1757_1759delAAA	c.(1756-1761)CAAAAA>CAA	p.K587del	PIK3R1_uc003jvb.2_In_Frame_Del_p.K587del|PIK3R1_uc003jvc.2_In_Frame_Del_p.K287del|PIK3R1_uc003jvd.2_In_Frame_Del_p.K317del|PIK3R1_uc003jve.2_In_Frame_Del_p.K266del|PIK3R1_uc011crb.1_In_Frame_Del_p.K257del	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	587					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.M582_D605>I(4)|p.Y580fs*1(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TGGTTGACTCAAAAAGGTGTTCG	0.355			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67591261	-	-	67591259	7	5	253	1	0	1	0	1	0	0	0	0	11918	130	5	0	1937	0	PIK3R1	5	67591259	In_Frame_Del	DEL	AAA	TCGA-74-6575-01A-11D-1845-08	30914065	67591259	113324001	43	18120											
PIK3R1	5295	broad.mit.edu	37	chr5	67593227	67593245	+	Splice_Site	DEL	CTCTCCTCTCTAGGGTGGA	-	-													ctcaaaagacagtttttcttCtctcctctctagggtggacg					rs143771559	by1000genomes	TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:67593227_67593245delCTCTCCTCTCTAGGGTGGA	uc003jva.2	+	16	2546	c.1986_splice	c.e16-1	p.V662_splice	PIK3R1_uc003jvb.2_Splice_Site_p.V662_splice|PIK3R1_uc003jvc.2_Splice_Site_p.V362_splice|PIK3R1_uc003jvd.2_Splice_Site_p.V392_splice|PIK3R1_uc003jve.2_Splice_Site_p.V341_splice	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AGTTTTTCTTCTCTCCTCTCTAGGGTGGACGGCGAAGTA	0.356			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67593245	-	-	67593227	8	5	253	1	0	1	0	1	0	0	1	0	11918	928	32	0		0	PIK3R1	5	67593227	Splice_Site	DEL	CTCTCCTCTCTAGGGTGGA	TCGA-74-6575-01A-11D-1845-08	1968	67593227	113322033	44	18121											
MCTP1	79772	broad.mit.edu	37	chr5	94044306	94044306	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccgaagcttttttgtaaattTattgatgcctgaaacaaagt	7	6	0	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:94044306T>A	uc003kkx.2	-	22	2839	c.2839A>T	c.(2839-2841)AAA>TAA	p.K947*	MCTP1_uc003kkv.2_Nonsense_Mutation_p.K726*|MCTP1_uc003kkw.2_Nonsense_Mutation_p.K640*|MCTP1_uc003kku.2_Nonsense_Mutation_p.K463*	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	947					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TTTGTAAATTTATTGATGCCT	0.353													A	94044306	A	A	94044306	4	1	253	1	0	0	0	0	0	1	0	0	9400	1763	61	5	168	5	MCTP1	5	94044306	Nonsense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	26451079	94044306	86870954	45	18122											
CHD1	1105	broad.mit.edu	37	chr5	98192335	98192335	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gtgagaacgatgatcagaatGagatctatcttttaaacttc	8	6	3	4			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:98192335G>A	uc003knf.2	-	35	5030	c.4882C>T	c.(4882-4884)CAT>TAT	p.H1628Y	CHD1_uc010jbn.2_Missense_Mutation_p.H354Y	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1628	3 X 5 AA repeats of H-S-D-H-R.|1.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TGATCAGAATGAGATCTATCT	0.383													A	98192335	A	A	98192335	3	1	253	1	0	0	0	0	1	0	0	0	3323	1290	45	3	254	3	CHD1	5	98192335	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	4148029	98192335	82722925	46	18123											
PCDHA10	56139	broad.mit.edu	37	chr5	140235776	140235776	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccttcgtgggccgcatcgCgcaggacctggggctggagc	16	14	0	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:140235776C>T	uc003lhx.2	+	1	143	c.143C>T	c.(142-144)GCG>GTG	p.A48V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.A48V|PCDHA10_uc011dad.1_Missense_Mutation_p.A48V	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	48	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCGCATCGCGCAGGACCTG	0.652													T	140235776	T	T	140235776	3	4	253	1	0	0	0	0	1	0	0	0	11520	768	27	1	145	1	PCDHA10	5	140235776	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	42043441	140235776	40679484	47	18124											
PCDHAC1	56135	broad.mit.edu	37	chr5	140307515	140307515	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctggacttcctgactctttcGaacccagtacctgaggacgc	9	14	1	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:140307515G>A	uc003lih.2	+	1	1214	c.1038G>A	c.(1036-1038)TCG>TCA	p.S346S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Silent_p.S346S	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	346	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACTCTTTCGAACCCAGTAC	0.517													A	140307515	A	A	140307515	2	1	253	1	0	0	0	0	0	0	0	1	11532	1045	37	2		2	PCDHAC1	5	140307515	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	71739	140307515	40607745	48	18125											
PCDHGB5	56101	broad.mit.edu	37	chr5	140778096	140778096	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccacacgccaaaattcacGcaaaattcctttgagctgca	6	13	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:140778096G>A	uc003lkf.1	+	1	402	c.402G>A	c.(400-402)ACG>ACA	p.T134T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.T134T	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	134	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAATTCACGCAAAATTCCT	0.423													A	140778096	A	A	140778096	2	1	253	1	0	0	0	0	0	0	0	1	11566	1074	38	1		1	PCDHGB5	5	140778096	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	470581	140778096	40137164	49	18126											
GABRA6	2559	broad.mit.edu	37	chr5	161128666	161128666	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctttggaggcaccagtaaaAtagaccagtattctcgaatt	8	9	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr5:161128666A>G	uc003lyu.2	+	9	1587	c.1249A>G	c.(1249-1251)ATA>GTA	p.I417V	GABRA6_uc003lyv.2_Missense_Mutation_p.I188V	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	417	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CACCAGTAAAATAGACCAGTA	0.468										TCGA Ovarian(5;0.080)			G	161128666	G	G	161128666	3	3	253	1	0	0	0	0	1	0	0	0	6165	101	4	4	1283	4	GABRA6	5	161128666	Missense_Mutation	SNP	A	TCGA-74-6575-01A-11D-1845-08	20350570	161128666	19786594	50	18127											
DSP	1832	broad.mit.edu	37	chr6	7584328	7584328	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcttggcatttatgaggccaTgaaaattggcttagtccgac	11	8	0	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr6:7584328T>C	uc003mxp.1	+	24	7112	c.6833T>C	c.(6832-6834)ATG>ACG	p.M2278T	DSP_uc003mxq.1_Missense_Mutation_p.M1679T	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2278	Plectin 7.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TATGAGGCCATGAAAATTGGC	0.473													C	7584328	C	C	7584328	3	2	253	1	0	0	0	0	1	0	0	0	4781	1464	51	4	6927	4	DSP	6	7584328	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08		7584328	163530739	51	18128											
DNAH11	8701	broad.mit.edu	37	chr7	21609750	21609750	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tagaagagtcactggaaaagGtgcaggtggctgttaacatc	13	6	1	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr7:21609750G>T	uc003svc.2	+	7	1289	c.1258G>T	c.(1258-1260)GTG>TTG	p.V420L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	420	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ACTGGAAAAGGTGCAGGTGGC	0.383									Kartagener_syndrome				T	21609750	T	T	21609750	3	4	253	1	0	0	0	0	1	0	0	0	4599	1261	44	5	1284	5	DNAH11	7	21609750	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08		21609750	137528913	52	18129											
NPC1L1	29881	broad.mit.edu	37	chr7	44578753	44578753	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cctgtagctggaccggttagGagccgtcaggatcacctggt	14	11	2	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr7:44578753G>T	uc003tlb.2	-	2	1299	c.1243C>A	c.(1243-1245)CCT>ACT	p.P415T	NPC1L1_uc003tlc.2_Missense_Mutation_p.P415T|NPC1L1_uc011kbw.1_Missense_Mutation_p.P415T|NPC1L1_uc003tld.2_Missense_Mutation_p.P415T	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	415	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GACCGGTTAGGAGCCGTCAGG	0.592													T	44578753	T	T	44578753	3	4	253	1	0	0	0	0	1	0	0	0	10571	1174	41	5	2912	5	NPC1L1	7	44578753	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	22969003	44578753	114559910	53	18130											
LANCL2	55915	broad.mit.edu	37	chr7	55467774	55467774	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagataggtccaggcaccGtgtgtgagtcagctattaaa	12	8	1	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr7:55467774G>A	uc003tqp.2	+	4	1233	c.655G>A	c.(655-657)GTG>ATG	p.V219M		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	219					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TCCAGGCACCGTGTGTGAGTC	0.458													A	55467774	A	A	55467774	3	1	253	1	0	0	0	0	1	0	0	0	8621	1145	40	1	669	1	LANCL2	7	55467774	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	10889021	55467774	103670889	54	18131											
SEMA3C	10512	broad.mit.edu	37	chr7	80374224	80374224	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaatattatgactctggcaActgattcctcctgtttctac	5	10	2	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr7:80374224A>G	uc003uhj.2	-	18	2804	c.2242T>C	c.(2242-2244)TTG>CTG	p.L748L	SEMA3C_uc011kgw.1_Silent_p.L766L	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	748					immune response|response to drug	membrane	receptor activity			ovary(1)	1						GACTCTGGCAACTGATTCCTC	0.393													G	80374224	G	G	80374224	2	3	253	1	0	0	0	0	0	0	0	1	14026	40	2	4		4	SEMA3C	7	80374224	Silent	SNP	A	TCGA-74-6575-01A-11D-1845-08	24906450	80374224	78764439	55	18132											
KIAA1324L	222223	broad.mit.edu	37	chr7	86521207	86521207	+	Splice_Site	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggaatatttgtattccagtcTaaatagtgataaaataaata	6	3	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr7:86521207T>A	uc011kha.1	-	21	3050	c.2865_splice	c.e21-1	p.K955_splice	KIAA1324L_uc003uif.1_Splice_Site_p.K715_splice|KIAA1324L_uc011kgz.1_Splice_Site_p.K841_splice|KIAA1324L_uc003uie.2_Splice_Site_p.K788_splice	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1							integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					TATTCCAGTCTAAATAGTGAT	0.303													A	86521207	A	A	86521207	5	1	253	1	0	0	0	0	0	0	1	0	8224	1536	53	5	234	5	KIAA1324L	7	86521207	Splice_Site	SNP	T	TCGA-74-6575-01A-11D-1845-08	6146983	86521207	72617456	56	18133											
COL1A2	1278	broad.mit.edu	37	chr7	94042435	94042435	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgataaaggtcatgctggtcTtgctggtgctcgggtaggtg	16	6	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr7:94042435T>A	uc003ung.1	+	26	2015	c.1544T>A	c.(1543-1545)CTT>CAT	p.L515H	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	515					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CATGCTGGTCTTGCTGGTGCT	0.368										HNSCC(75;0.22)			A	94042435	A	A	94042435	3	1	253	1	0	0	0	0	1	0	0	0	3678	1609	56	5	1646	5	COL1A2	7	94042435	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	7521228	94042435	65096228	57	18134											
WNT2	7472	broad.mit.edu	37	chr7	116955387	116955387	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aggagatggcataaacaaagGcagattcccgactacctgaa	10	9	0	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr7:116955387G>T	uc003viz.2	-	3	626	c.326C>A	c.(325-327)GCC>GAC	p.A109D	WNT2_uc003vja.2_Intron	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	109					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		ATAAACAAAGGCAGATTCCCG	0.403													T	116955387	T	T	116955387	3	4	253	1	0	0	0	0	1	0	0	0	17383	1203	42	5	768	5	WNT2	7	116955387	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	22912952	116955387	42183276	58	18135											
HYAL4	23553	broad.mit.edu	37	chr7	123508674	123508674	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggaggtctcccacagaacaTaagtttacaagtacatctgg	9	9	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr7:123508674T>C	uc003vlc.2	+	3	985	c.347T>C	c.(346-348)ATA>ACA	p.I116T	HYAL4_uc011knz.1_Missense_Mutation_p.I116T	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	116	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						CCACAGAACATAAGTTTACAA	0.393													C	123508674	C	C	123508674	3	2	253	1	0	0	0	0	1	0	0	0	7466	1406	49	4	349	4	HYAL4	7	123508674	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	6553287	123508674	35629989	59	18136											
PLXNA4	91584	broad.mit.edu	37	chr7	131865369	131865369	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actttgtgcctgccgatgagGttgggggactcgcagagcag	16	9	0	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr7:131865369G>A	uc003vra.3	-	19	3844	c.3615C>T	c.(3613-3615)AAC>AAT	p.N1205N		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1205	IPT/TIG 4.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGCCGATGAGGTTGGGGGACT	0.602													A	131865369	A	A	131865369	2	1	253	1	0	0	0	0	0	0	0	1	12122	1252	44	3		3	PLXNA4	7	131865369	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	8356695	131865369	27273294	60	18137											
PLAT	5327	broad.mit.edu	37	chr8	42036566	42036566	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gagcctccttcagccgctccGaatagaaaggagacactgaa	10	12	1	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr8:42036566G>A	uc003xos.2	-	13	1588	c.1379C>T	c.(1378-1380)TCG>TTG	p.S460L	PLAT_uc010lxf.1_Missense_Mutation_p.S377L|PLAT_uc010lxg.1_Missense_Mutation_p.S285L|PLAT_uc003xot.2_Missense_Mutation_p.S414L|PLAT_uc011lcm.1_Missense_Mutation_p.S371L|PLAT_uc011lcn.1_Missense_Mutation_p.S334L	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	460	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CAGCCGCTCCGAATAGAAAGG	0.423													A	42036566	A	A	42036566	3	1	253	1	0	0	0	0	1	0	0	0	12021	1059	37	2	317	2	PLAT	8	42036566	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08		42036566	104327456	61	18138											
RP1	6101	broad.mit.edu	37	chr8	55533600	55533600	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtcaagttccaccccctcGccatttgagcctcactcatc	6	17	3	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr8:55533600G>A	uc003xsd.1	+	2	222	c.74G>A	c.(73-75)CGC>CAC	p.R25H	RP1_uc011ldy.1_Missense_Mutation_p.R25H	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	25					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCACCCCCTCGCCATTTGAGC	0.517													A	55533600	A	A	55533600	3	1	253	1	0	0	0	0	1	0	0	0	13532	1087	38	1	76	1	RP1	8	55533600	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	13497034	55533600	90830422	62	18139											
NCOA2	10499	broad.mit.edu	37	chr8	71057034	71057034	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gtgatgtcaagtggtaaattCtggtttggcaataacctgcc	11	7	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr8:71057034C>G	uc003xyn.1	-	13	2817	c.2655G>C	c.(2653-2655)CAG>CAC	p.Q885H	NCOA2_uc011lfb.1_Intron	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	885					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GTGGTAAATTCTGGTTTGGCA	0.423			T	RUNXBP2	AML								G	71057034	G	G	71057034	3	3	253	1	0	0	0	0	1	0	0	0	10229	912	32	5	1783	5	NCOA2	8	71057034	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	15523434	71057034	75306988	63	18140											
TTC39B	158219	broad.mit.edu	37	chr9	15214139	15214139	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agagacaaagtaaattaccaGgggcgaagcaattctaaggc	11	7	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr9:15214139G>C	uc003zlr.1	-	4	403	c.282C>G	c.(280-282)CCC>CCG	p.P94P	TTC39B_uc003zlq.1_Silent_p.P63P|TTC39B_uc011lmp.1_5'UTR|TTC39B_uc010mie.1_Silent_p.P94P|TTC39B_uc011lmq.1_Silent_p.P94P|TTC39B_uc011lmr.1_Intron|TTC39B_uc010mif.1_Silent_p.P94P|TTC39B_uc003zls.1_5'UTR|TTC39B_uc010mig.1_Silent_p.P63P|TTC39B_uc011lms.1_RNA	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	94							binding			ovary(1)	1						TAAATTACCAGGGGCGAAGCA	0.373													C	15214139	C	C	15214139	2	2	253	1	0	0	0	0	0	0	0	1	16705	987	35	5		5	TTC39B	9	15214139	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08		15214139	125999292	64	18141											
PTPN3	5774	broad.mit.edu	37	chr9	112200417	112200417	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgctgctcatgcagagattcGacttttgttaaaaagtcctc	8	9	1	1	rs148263399		TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr9:112200417G>A	uc004bed.2	-	8	676	c.564C>T	c.(562-564)GTC>GTT	p.V188V	PTPN3_uc004beb.2_Silent_p.V57V|PTPN3_uc004bec.2_Silent_p.V57V|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.V188V|PTPN3_uc011lwh.1_Silent_p.V79V	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	188	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						GCAGAGATTCGACTTTTGTTA	0.438													A	112200417	A	A	112200417	2	1	253	1	0	0	0	0	0	0	0	1	12789	1045	37	2		2	PTPN3	9	112200417	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	96986278	112200417	29013014	65	18142											
CRAT	1384	broad.mit.edu	37	chr9	131864744	131864744	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttgctgaagttgctgactgTgtcctgcttggggcccggca	14	11	0	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr9:131864744T>C	uc004bxh.2	-	5	847	c.565A>G	c.(565-567)ACA>GCA	p.T189A	CRAT_uc004bxg.2_Missense_Mutation_p.T168A|CRAT_uc004bxk.3_Missense_Mutation_p.T168A	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	189					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	TTGCTGACTGTGTCCTGCTTG	0.617													C	131864744	C	C	131864744	3	2	253	1	0	0	0	0	1	0	0	0	3847	1696	59	4	1355	4	CRAT	9	131864744	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	19664327	131864744	9348687	66	18143											
POMT1	10585	broad.mit.edu	37	chr9	134394274	134394274	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tatcggcaactggagatcgtCggggagaagctgtcccgggg	17	9	0	2	rs139687326	byFrequency	TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr9:134394274C>T	uc004cav.2	+	15	1684	c.1482C>T	c.(1480-1482)GTC>GTT	p.V494V	POMT1_uc004cax.2_Silent_p.V472V|POMT1_uc011mcj.1_Silent_p.V250V|POMT1_uc004cau.2_Silent_p.V472V|POMT1_uc004caw.2_Silent_p.V418V|POMT1_uc011mck.1_Silent_p.V355V|POMT1_uc011mcl.1_Silent_p.V320V|POMT1_uc011mcm.1_Silent_p.V442V|POMT1_uc011mcn.1_3'UTR	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	494	MIR 3.				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TGGAGATCGTCGGGGAGAAGC	0.677													T	134394274	T	T	134394274	2	4	253	1	0	0	0	0	0	0	0	1	12245	871	31	2		2	POMT1	9	134394274	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	2529530	134394274	6819157	67	18144											
COL5A1	1289	broad.mit.edu	37	chr9	137704532	137704532	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaggtcccccaggtggaataGgaaaccctggtgcagtggga	15	9	0	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr9:137704532G>A	uc004cfe.2	+	48	4208	c.3826G>A	c.(3826-3828)GGA>AGA	p.G1276R		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1276	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGGTGGAATAGGAAACCCTGG	0.557													A	137704532	A	A	137704532	3	1	253	1	0	0	0	0	1	0	0	0	3696	1001	35	3	4016	3	COL5A1	9	137704532	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	3310258	137704532	3508899	68	18145											
LCN6	158062	broad.mit.edu	37	chr9	139639655	139639655	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgttgaagggctcgtcccCgaactccagctgagtgaaga	14	10	0	4			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr9:139639655C>T	uc004ciy.2	-	4	424	c.379G>A	c.(379-381)GGG>AGG	p.G127R	LCN10_uc004civ.2_5'Flank|LCN10_uc011med.1_5'Flank|LCN10_uc010nbq.2_5'Flank|LCN10_uc011mee.1_5'Flank|LCN10_uc011mef.1_5'Flank|LCN10_uc004ciw.2_RNA|uc004ciz.1_5'Flank	NM_198946	NP_945184	P62502	LCN6_HUMAN	lipocalin 6 precursor	127					single fertilization	extracellular region	binding				0	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.32e-06)|Epithelial(140;7.83e-05)		GGCTCGTCCCCGAACTCCAGC	0.607													T	139639655	T	T	139639655	3	4	253	1	0	0	0	0	1	0	0	0	8685	652	23	2	120	2	LCN6	9	139639655	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	1935123	139639655	1573776	69	18146											
C11orf35	256329	broad.mit.edu	37	chr11	556905	556905	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagcgcggtggtcccggggCgggtgccctatcacctgcac	16	14	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr11:556905C>T	uc001lpx.2	-	8	969	c.906G>A	c.(904-906)CCG>CCA	p.P302P	uc001lpy.2_5'Flank|uc001lpz.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	302										pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGTCCCGGGGCGGGTGCCCTA	0.697													T	556905	T	T	556905	2	4	253	1	0	0	0	0	0	0	0	1	1638	755	27	1		1	C11orf35	11	556905	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08		556905	134449611	70	18147											
MUC5B	727897	broad.mit.edu	37	chr11	1156628	1156628	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggctctgtggggacttcaaCgggatgcccgtggtcagcga	17	10	3	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr11:1156628C>T	uc009ycr.1	+	7	771	c.645C>T	c.(643-645)AAC>AAT	p.N215N		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	211	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGGACTTCAACGGGATGCCCG	0.617													T	1156628	T	T	1156628	2	4	253	1	0	0	0	0	0	0	0	1	9979	551	19	1		1	MUC5B	11	1156628	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	599723	1156628	133849888	71	18148											
SERPING1	710	broad.mit.edu	37	chr11	57365774	57365776	+	In_Frame_Del	DEL	CTG	-	-													ggctgaccctgctgaccctcCtgctgctgctgctggctggg							TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr11:57365774_57365776delCTG	uc001nkp.1	+	2	222_224	c.31_33delCTG	c.(31-33)CTGdel	p.L15del	SERPING1_uc001nkq.1_In_Frame_Del_p.L15del|SERPING1_uc010rju.1_Intron|SERPING1_uc010rjv.1_In_Frame_Del_p.L15del|SERPING1_uc001nkr.1_In_Frame_Del_p.L15del|SERPING1_uc009ymi.1_In_Frame_Del_p.L15del|SERPING1_uc009ymj.1_In_Frame_Del_p.L15del|SERPING1_uc001nks.1_5'UTR	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	15					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						GCTGACCCTCCTGCTGCTGCTGC	0.709									Hereditary_Angioedema				-	57365776	-	-	57365774	7	5	253	1	0	1	0	1	0	0	0	0	14116	680	24	0	33	0	SERPING1	11	57365774	In_Frame_Del	DEL	CTG	TCGA-74-6575-01A-11D-1845-08	56209146	57365774	77640742	72	18149											
C11orf2	738	broad.mit.edu	37	chr11	64876819	64876819	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtccactctatgtgccagaCggctcagagcttctgcgaca	10	14	3	2	rs140677028		TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr11:64876819C>T	uc001ocr.1	+	6	1551	c.1511C>T	c.(1510-1512)ACG>ATG	p.T504M	TM7SF2_uc001oct.2_5'Flank|TM7SF2_uc010rny.1_5'Flank|TM7SF2_uc001ocu.2_5'Flank|TM7SF2_uc001ocv.2_5'Flank|C11orf2_uc001ocs.1_Missense_Mutation_p.T380M	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	504					lipid transport|protein transport	Golgi apparatus|integral to membrane					0						ATGTGCCAGACGGCTCAGAGC	0.647													T	64876819	T	T	64876819	3	4	253	1	0	0	0	0	1	0	0	0	1633	536	19	1	1533	1	C11orf2	11	64876819	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	7511045	64876819	70129697	73	18150											
DYNC2H1	79659	broad.mit.edu	37	chr11	102988581	102988581	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacttgacaaacttggcaaaCgccttgaagaggtatcaatt	8	9	1	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr11:102988581C>T	uc001pho.2	+	6	1132	c.988C>T	c.(988-990)CGC>TGC	p.R330C	DYNC2H1_uc001phn.1_Missense_Mutation_p.R330C|DYNC2H1_uc009yxe.1_Missense_Mutation_p.R330C	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	330	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		ACTTGGCAAACGCCTTGAAGA	0.333													T	102988581	T	T	102988581	3	4	253	1	0	0	0	0	1	0	0	0	4846	536	19	1	1010	1	DYNC2H1	11	102988581	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	38111762	102988581	32017935	74	18151											
TECTA	7007	broad.mit.edu	37	chr11	120998519	120998519	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtgcacaagcagctgcccCgacacatgctccgacctgac	10	16	0	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr11:120998519C>T	uc010rzo.1	+	8	1833	c.1833C>T	c.(1831-1833)CCC>CCT	p.P611P		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	611	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCAGCTGCCCCGACACATGCT	0.637													T	120998519	T	T	120998519	2	4	253	1	0	0	0	0	0	0	0	1	15744	639	23	2		2	TECTA	11	120998519	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	18009938	120998519	14007997	75	18152											
TECTA	7007	broad.mit.edu	37	chr11	121031074	121031074	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaccttgcgagggaagccGgtggtaagcagcgtggtgct	18	8	0	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr11:121031074G>A	uc010rzo.1	+	14	4920	c.4920G>A	c.(4918-4920)CCG>CCA	p.P1640P		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1640	VWFD 4.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GAGGGAAGCCGGTGGTAAGCA	0.542													A	121031074	A	A	121031074	2	1	253	1	0	0	0	0	0	0	0	1	15744	1103	39	2		2	TECTA	11	121031074	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	32555	121031074	13975442	76	18153											
TAS2R10	50839	broad.mit.edu	37	chr12	10978396	10978396	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgagatcccagactgtgtcaTtcttcgttttataatcatta	6	8	3	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr12:10978396T>C	uc001qyy.1	-	1	473	c.473A>G	c.(472-474)AAT>AGT	p.N158S		NM_023921	NP_076410	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	158	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity				0						GACTGTGTCATTCTTCGTTTT	0.299													C	10978396	C	C	10978396	3	2	253	1	0	0	0	0	1	0	0	0	15563	1493	52	4	454	4	TAS2R10	12	10978396	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08		10978396	122873499	77	18154											
GRIN2B	2904	broad.mit.edu	37	chr12	13720091	13720091	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	atggccgcccccaacatgtaGaagacccctgccatgttgtc	9	15	0	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr12:13720091G>C	uc001rbt.2	-	12	2645	c.2466C>G	c.(2464-2466)TTC>TTG	p.F822L		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	822	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCAACATGTAGAAGACCCCTG	0.507													C	13720091	C	C	13720091	3	2	253	1	0	0	0	0	1	0	0	0	6780	933	33	5	1996	5	GRIN2B	12	13720091	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	2741695	13720091	120131804	78	18155											
MTERFD3	80298	broad.mit.edu	37	chr12	107371558	107371559	+	Frame_Shift_Ins	INS	-	AT	AT													ctctcttatctgagctatggINSaaattccttctctcaataat							TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr12:107371558_107371559insAT	uc001tme.1	-	2	2753_2754	c.934_935insAT	c.(934-936)TCCfs	p.S312fs	MTERFD3_uc001tmf.1_Frame_Shift_Ins_p.S312fs|MTERFD3_uc001tmg.1_Frame_Shift_Ins_p.S312fs|MTERFD3_uc001tmh.1_Frame_Shift_Ins_p.S312fs	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						CTGAGCTATGGAAATTCCTTCT	0.371													AT	107371559	AT	AT	107371558	7	5	253	1	0	1	1	0	0	0	0	0	9921	1174	41	0	226	0	MTERFD3	12	107371558	Frame_Shift_Ins	INS	-	TCGA-74-6575-01A-11D-1845-08	93651467	107371558	26480337	79	18156											
PTPN11	5781	broad.mit.edu	37	chr12	112888189	112888189	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actatgacctgtatggagggGagaaatttgccactttggct	12	7	0	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr12:112888189G>A	uc001ttx.2	+	3	585	c.205G>A	c.(205-207)GAG>AAG	p.E69K	PTPN11_uc001ttw.1_Missense_Mutation_p.E69K	NM_002834	NP_002825	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type	69	SH2 1.		E -> K (in JMML; also in myelodysplastic syndrome).|E -> Q (in NS1).		axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding	p.E69K(15)|p.E69V(1)|p.E69G(1)		haematopoietic_and_lymphoid_tissue(375)|lung(6)|autonomic_ganglia(2)|soft_tissue(2)|central_nervous_system(2)|large_intestine(1)|skin(1)|ovary(1)|NS(1)|kidney(1)	392						GTATGGAGGGGAGAAATTTGC	0.428			Mis		JMML|AML|MDS		Noonan Syndrome		Noonan_syndrome				A	112888189	A	A	112888189	3	1	253	1	0	0	0	0	1	0	0	0	12780	1175	41	3	215	3	PTPN11	12	112888189	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	5516631	112888189	20963706	80	18157											
KSR2	283455	broad.mit.edu	37	chr12	117993006	117993006	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gttggttttggggagcgtctGactgatgtgcaggtctgaat	16	5	2	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr12:117993006G>C	uc001two.2	-	9	1454	c.1399C>G	c.(1399-1401)CAG>GAG	p.Q467E		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	496					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGAGCGTCTGACTGATGTGC	0.577													C	117993006	C	C	117993006	3	2	253	1	0	0	0	0	1	0	0	0	8582	1299	45	5	1414	5	KSR2	12	117993006	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	5104817	117993006	15858889	81	18158											
GOLGA3	2802	broad.mit.edu	37	chr12	133373156	133373156	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gctgctccagggatgccgccGagtccgccatcctctgcagc	12	17	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr12:133373156G>A	uc001ukz.1	-	10	2628	c.2069C>T	c.(2068-2070)TCG>TTG	p.S690L	GOLGA3_uc001ula.1_Missense_Mutation_p.S690L|GOLGA3_uc001ulb.2_Missense_Mutation_p.S690L	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	690	Gln-rich.|Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GGATGCCGCCGAGTCCGCCAT	0.622													A	133373156	A	A	133373156	3	1	253	1	0	0	0	0	1	0	0	0	6554	1059	37	2	2625	2	GOLGA3	12	133373156	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	15380150	133373156	478739	82	18159											
TUBA3C	7278	broad.mit.edu	37	chr13	19751438	19751438	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cacgatctgcccaatcaggcGattgaggttggtgtacgtgg	14	9	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr13:19751438G>A	uc009zzj.2	-	4	734	c.685C>T	c.(685-687)CGC>TGC	p.R229C		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	229					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CCAATCAGGCGATTGAGGTTG	0.547													A	19751438	A	A	19751438	3	1	253	1	0	0	0	0	1	0	0	0	16743	1058	37	2	675	2	TUBA3C	13	19751438	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08		19751438	95418440	83	18160											
PAN3	255967	broad.mit.edu	37	chr13	28794483	28794483	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agttttctctcacccatccaTgggaagccctgctactgctg	8	14	2	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr13:28794483T>C	uc001urz.2	+	5	538	c.530T>C	c.(529-531)ATG>ACG	p.M177T	PAN3_uc010tdo.1_Missense_Mutation_p.M323T|PAN3_uc001ury.2_5'UTR|PAN3_uc001urx.2_Missense_Mutation_p.M123T	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	323	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		CACCCATCCATGGGAAGCCCT	0.448													C	28794483	C	C	28794483	3	2	253	1	0	0	0	0	1	0	0	0	11415	1464	51	4	990	4	PAN3	13	28794483	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	9043045	28794483	86375395	84	18161											
OR4M1	441670	broad.mit.edu	37	chr14	20248896	20248896	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgctaccatcatgaatcgaCgtctctgctgtatcctggtg	9	11	2	1	rs148303756	byFrequency	TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr14:20248896C>T	uc010tku.1	+	1	415	c.415C>T	c.(415-417)CGT>TGT	p.R139C		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATGAATCGACGTCTCTGCTG	0.517													T	20248896	T	T	20248896	3	4	253	1	0	0	0	0	1	0	0	0	11075	536	19	1	417	1	OR4M1	14	20248896	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08		20248896	87100644	85	18162											
NRXN3	9369	broad.mit.edu	37	chr14	79432392	79432392	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatggtgggagaccatacccGtttggagttccacaacattg	11	9	0	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr14:79432392G>A	uc001xun.2	+	9	1792	c.1301G>A	c.(1300-1302)CGT>CAT	p.R434H	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.R559H	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	807	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GACCATACCCGTTTGGAGTTC	0.428													A	79432392	A	A	79432392	3	1	253	1	0	0	0	0	1	0	0	0	10667	1145	40	1	1327	1	NRXN3	14	79432392	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	59183496	79432392	27917148	86	18163											
CCDC88C	440193	broad.mit.edu	37	chr14	91755541	91755541	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcggcctgtgatctgagcGgctgagaggccgccggcgag	17	12	2	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr14:91755541G>A	uc010aty.2	-	25	4448	c.4349C>T	c.(4348-4350)CCG>CTG	p.P1450L		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1450					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				TGATCTGAGCGGCTGAGAGGC	0.652													A	91755541	A	A	91755541	3	1	253	1	0	0	0	0	1	0	0	0	2865	1116	39	2	1761	2	CCDC88C	14	91755541	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	12323149	91755541	15593999	87	18164											
ADAM10	102	broad.mit.edu	37	chr15	58957380	58957380	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacagcccccctgaggaccGtatttatggggatagtctaa	11	11	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr15:58957380G>A	uc002afd.1	-	5	945	c.501C>T	c.(499-501)TAC>TAT	p.Y167Y	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Intron|ADAM10_uc002afe.1_Intron|ADAM10_uc002afg.2_Silent_p.Y167Y	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	167	Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		CCTGAGGACCGTATTTATGGG	0.348													A	58957380	A	A	58957380	2	1	253	1	0	0	0	0	0	0	0	1	234	1140	40	1		1	ADAM10	15	58957380	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08		58957380	43574012	88	18165											
UACA	55075	broad.mit.edu	37	chr15	70959297	70959297	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttggccaatttttcatttaaGctagaaatctgtgtctccaa	6	8	3	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr15:70959297G>C	uc002asr.2	-	16	3830	c.3726C>G	c.(3724-3726)AGC>AGG	p.S1242R	UACA_uc010uke.1_Missense_Mutation_p.S1133R|UACA_uc002asq.2_Missense_Mutation_p.S1229R|UACA_uc010bin.1_Missense_Mutation_p.S1217R	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	1242	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						TTTCATTTAAGCTAGAAATCT	0.323													C	70959297	C	C	70959297	3	2	253	1	0	0	0	0	1	0	0	0	16821	962	34	5	540	5	UACA	15	70959297	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	12001917	70959297	31572095	89	18166											
ALDH1A3	220	broad.mit.edu	37	chr15	101432805	101432805	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaaccctcagatactttgcaGggtgggcagacaaaatccag	11	10	1	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr15:101432805G>T	uc002bwn.3	+	4	540	c.436G>T	c.(436-438)GGG>TGG	p.G146W	ALDH1A3_uc010bpb.2_Intron	NM_000693	NP_000684	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1A3	146					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	ATACTTTGCAGGGTGGGCAGA	0.473													T	101432805	T	T	101432805	3	4	253	1	0	0	0	0	1	0	0	0	492	1000	35	5	450	5	ALDH1A3	15	101432805	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	30473508	101432805	1098587	90	18167											
BTBD12	84464	broad.mit.edu	37	chr16	3658781	3658781	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttgattccatgttttttcAccctttggaaaaagctagcg	7	10	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr16:3658781A>G	uc002cvp.2	-	2	812	c.185T>C	c.(184-186)GTG>GCG	p.V62A	BTBD12_uc002cvq.1_Missense_Mutation_p.V62A	NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	62	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						ATGTTTTTTCACCCTTTGGAA	0.438								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				G	3658781	G	G	3658781	3	3	253	1	0	0	0	0	1	0	0	0	1540	159	6	4	5375	4	BTBD12	16	3658781	Missense_Mutation	SNP	A	TCGA-74-6575-01A-11D-1845-08		3658781	86695972	91	18168											
CORO7	79585	broad.mit.edu	37	chr16	4411454	4411454	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagtgccgtgtcgggcaggCggccaggcttccgtagctgt	17	12	0	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr16:4411454C>T	uc002cwh.3	-	17	1715	c.1595G>A	c.(1594-1596)CGC>CAC	p.R532H	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.R532H|CORO7_uc002cwg.3_Missense_Mutation_p.R312H|CORO7_uc010uxh.1_Missense_Mutation_p.R514H|CORO7_uc010uxi.1_Missense_Mutation_p.R447H|CORO7_uc002cwi.1_Missense_Mutation_p.R312H|CORO7_uc010uxj.1_RNA	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	532						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						GTCGGGCAGGCGGCCAGGCTT	0.667													T	4411454	T	T	4411454	3	4	253	1	0	0	0	0	1	0	0	0	3759	768	27	1	1230	1	CORO7	16	4411454	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	752673	4411454	85943299	92	18169											
NF1	4763	broad.mit.edu	37	chr17	29654677	29654678	+	Frame_Shift_Ins	INS	-	C	C													gcaaaccagggcacgccgctINScaccttcatgcaccaggagt							TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr17:29654677_29654678insC	uc002hgg.2	+	38	5762_5763	c.5429_5430insC	c.(5428-5430)CTCfs	p.L1810fs	NF1_uc002hgh.2_Frame_Shift_Ins_p.L1789fs|NF1_uc002hgi.1_Frame_Shift_Ins_p.L822fs|NF1_uc010cso.2_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1810					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GGCACGCCGCTCACCTTCATGC	0.48			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			C	29654678	C	C	29654677	7	5	253	1	0	1	1	0	0	0	0	0	10356	1551	54	0	5640	0	NF1	17	29654677	Frame_Shift_Ins	INS	-	TCGA-74-6575-01A-11D-1845-08		29654677	51540533	93	18170											
RAB11FIP4	84440	broad.mit.edu	37	chr17	29850999	29850999	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caagctgaagcaagagaacaCacagctggtgcacaggtcaa	11	10	1	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr17:29850999C>A	uc002hgn.1	+	9	1347	c.1118C>A	c.(1117-1119)ACA>AAA	p.T373K	RAB11FIP4_uc002hgo.2_Missense_Mutation_p.T271K	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	373	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				CAAGAGAACACACAGCTGGTG	0.597													A	29850999	A	A	29850999	3	1	253	1	0	0	0	0	1	0	0	0	12896	478	17	5	1152	5	RAB11FIP4	17	29850999	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	196322	29850999	51344211	94	18171											
ABCA10	10349	broad.mit.edu	37	chr17	67211983	67211983	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attccagcagtgaaggcaaaAgggctaagaagacttaatac	10	7	0	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr17:67211983A>G	uc010dfa.1	-	9	1710	c.831T>C	c.(829-831)CCT>CCC	p.P277P	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_5'Flank|ABCA10_uc010dfc.1_Silent_p.P169P	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	277	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TGAAGGCAAAAGGGCTAAGAA	0.353													G	67211983	G	G	67211983	2	3	253	1	0	0	0	0	0	0	0	1	29	59	3	4		4	ABCA10	17	67211983	Silent	SNP	A	TCGA-74-6575-01A-11D-1845-08	37360984	67211983	13983227	95	18172											
CTAGE1	64693	broad.mit.edu	37	chr18	19996611	19996611	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggcatggctgatcatttcGtctactttagaaagtttctc	9	8	3	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr18:19996611G>A	uc002ktv.1	-	1	1268	c.1164C>T	c.(1162-1164)GAC>GAT	p.D388D		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	388	Potential.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TGATCATTTCGTCTACTTTAG	0.343													A	19996611	A	A	19996611	2	1	253	1	0	0	0	0	0	0	0	1	3992	1136	40	1		1	CTAGE1	18	19996611	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08		19996611	58080637	96	18173											
DSC2	1824	broad.mit.edu	37	chr18	28662997	28662997	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tgaccatccatgtcttgtacTtttattttcaactggtactt	5	9	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr18:28662997T>A	uc002kwl.3	-	8	1426	c.972A>T	c.(970-972)AAA>AAT	p.K324N	DSC2_uc002kwk.3_Missense_Mutation_p.K324N	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	324	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TGTCTTGTACTTTTATTTTCA	0.308													A	28662997	A	A	28662997	3	1	253	1	0	0	0	0	1	0	0	0	4766	1606	56	5	1809	5	DSC2	18	28662997	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	8666386	28662997	49414251	97	18174											
CELF4	56853	broad.mit.edu	37	chr18	34854357	34854357	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagccatctgctgcattcGccgcatcgtgcgctccttgt	10	16	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr18:34854357G>A	uc002lae.2	-	6	1114	c.718C>T	c.(718-720)CGA>TGA	p.R240*	CELF4_uc010dnd.1_Nonsense_Mutation_p.R239*|CELF4_uc002lag.2_Nonsense_Mutation_p.R230*|CELF4_uc002laf.2_Nonsense_Mutation_p.R235*|CELF4_uc002lai.2_Nonsense_Mutation_p.R225*|CELF4_uc002lah.1_5'Flank|CELF4_uc002laj.1_Missense_Mutation_p.A75V	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	240	Sufficient for RNA-binding and MSE- dependent splicing activity.|Necessary for TNNT2 exon 5 inclusion.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						TGCTGCATTCGCCGCATCGTG	0.667													A	34854357	A	A	34854357	4	1	253	1	0	0	0	0	0	1	0	0	3218	1095	38	1	770	1	CELF4	18	34854357	Nonsense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	6191360	34854357	43222891	98	18175											
PPAP2C	8612	broad.mit.edu	37	chr19	288137	288137	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatcctcgcttgtacggggcGttcaccagcgtcaggatagc	12	12	2	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:288137G>A	uc002loi.2	-	2	186	c.87C>T	c.(85-87)AAC>AAT	p.N29N	PPAP2C_uc002loh.2_Silent_p.N50N|PPAP2C_uc002loj.2_Translation_Start_Site	NM_003712	NP_003703	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C isoform 1	29					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTACGGGGCGTTCACCAGCG	0.617													A	288137	A	A	288137	2	1	253	1	0	0	0	0	0	0	0	1	12292	1136	40	1		1	PPAP2C	19	288137	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08		288137	58840846	99	18176											
SLC39A3	29985	broad.mit.edu	37	chr19	2733313	2733313	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatactccgagtcgctgccCacgtccgatccggcgttgaa	10	15	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:2733313C>T	uc002lwg.2	-	3	635	c.381G>A	c.(379-381)GTG>GTA	p.V127V	SLC39A3_uc010xgy.1_Silent_p.V127V	NM_144564	NP_653165	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter),	127	Cytoplasmic (Potential).					integral to membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCGCTGCCCACGTCCGATC	0.662													T	2733313	T	T	2733313	2	4	253	1	0	0	0	0	0	0	0	1	14619	581	21	3		3	SLC39A3	19	2733313	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	2445176	2733313	56395670	100	18177											
VAV1	7409	broad.mit.edu	37	chr19	6854017	6854017	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgacttctgcgcccgagacCgatcagagctgtcgctcaag	11	13	3	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:6854017C>T	uc002mfu.1	+	26	2489	c.2392C>T	c.(2392-2394)CGA>TGA	p.R798*	VAV1_uc010xjh.1_Nonsense_Mutation_p.R766*|VAV1_uc010dva.1_Nonsense_Mutation_p.R776*|VAV1_uc002mfv.1_Nonsense_Mutation_p.R743*	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	798	SH3 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CGCCCGAGACCGATCAGAGCT	0.552													T	6854017	T	T	6854017	4	4	253	1	0	0	0	0	0	1	0	0	17128	644	23	2	2494	2	VAV1	19	6854017	Nonsense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	4120704	6854017	52274966	101	18178											
AKAP8L	26993	broad.mit.edu	37	chr19	15510183	15510183	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgcctgcctgcaacttgcGcttggtctggccattttcat	9	13	2	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:15510183G>A	uc002naw.1	-	9	1186	c.1087C>T	c.(1087-1089)CGC>TGC	p.R363C	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Missense_Mutation_p.R302C	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	363	Nuclear localization signal (Potential).					cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						TGCAACTTGCGCTTGGTCTGG	0.602													A	15510183	A	A	15510183	3	1	253	1	0	0	0	0	1	0	0	0	458	1087	38	1	877	1	AKAP8L	19	15510183	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	8656166	15510183	43618800	102	18179											
CPAMD8	27151	broad.mit.edu	37	chr19	17014389	17014389	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgcatcaggcagcagccGtcccccttggcactcacaaa	8	17	2	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:17014389G>A	uc002nfb.2	-	34	4625	c.4593C>T	c.(4591-4593)GAC>GAT	p.D1531D	CPAMD8_uc002nfd.1_Translation_Start_Site	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1484						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGCAGCAGCCGTCCCCCTTGG	0.617													A	17014389	A	A	17014389	2	1	253	1	0	0	0	0	0	0	0	1	3795	1136	40	1		1	CPAMD8	19	17014389	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	1504206	17014389	42114594	103	18180											
SLC25A42	284439	broad.mit.edu	37	chr19	19206999	19206999	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctgaggctgtcctgtcctcGtccgtctcatcaaaggcaag	11	13	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:19206999G>T	uc002nlf.1	+	2	217	c.66G>T	c.(64-66)TCG>TCT	p.S22S	SLC25A42_uc010xqn.1_Silent_p.S74S	NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	22					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			TCCTGTCCTCGTCCGTCTCAT	0.647													T	19206999	T	T	19206999	2	4	253	1	0	0	0	0	0	0	0	1	14507	1132	40	5		5	SLC25A42	19	19206999	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	2192610	19206999	39921984	104	18181											
MEGF8	1954	broad.mit.edu	37	chr19	42841352	42841352	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcttgccccgccaggaaccCctgagggtgagtggtccctg	14	14	0	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:42841352C>T	uc002otl.3	+	8	2142	c.1507C>T	c.(1507-1509)CCT>TCT	p.P503S	MEGF8_uc002otm.3_Missense_Mutation_p.P44S	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	503	Extracellular (Potential).|Kelch 5.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GCCAGGAACCCCTGAGGGTGA	0.572													T	42841352	T	T	42841352	3	4	253	1	0	0	0	0	1	0	0	0	9463	623	22	3	1537	3	MEGF8	19	42841352	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	23634353	42841352	16287631	105	18182											
ETHE1	23474	broad.mit.edu	37	chr19	44015698	44015698	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcctggggtgtggccaggGctggccctggtctccaacgc	16	14	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:44015698G>A	uc002owp.2	-	4	463	c.396C>T	c.(394-396)AGC>AGT	p.S132S	ETHE1_uc010eiu.1_Silent_p.S132S	NM_014297	NP_055112	O95571	ETHE1_HUMAN	ETHE1 protein precursor	132						mitochondrial matrix|nucleus	hydrolase activity|metal ion binding				0		Prostate(69;0.0153)				TGTGGCCAGGGCTGGCCCTGG	0.602													A	44015698	A	A	44015698	2	1	253	1	0	0	0	0	0	0	0	1	5272	1194	42	3		3	ETHE1	19	44015698	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	1174346	44015698	15113285	106	18183											
GPR32	2854	broad.mit.edu	37	chr19	51274617	51274617	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgggtccatgccaaccggCccaagaggctgctgctggtg	15	13	0	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:51274617C>T	uc010ycf.1	+	1	760	c.760C>T	c.(760-762)CCC>TCC	p.P254S		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	254	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TGCCAACCGGCCCAAGAGGCT	0.612													T	51274617	T	T	51274617	3	4	253	1	0	0	0	0	1	0	0	0	6688	739	26	3	762	3	GPR32	19	51274617	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	7258919	51274617	7854366	107	18184											
KLK8	11202	broad.mit.edu	37	chr19	51503469	51503469	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtatttcttgctctgggccAtctttattctgtaggctgtg	11	8	4	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:51503469A>G	uc002pur.1	-	4	455	c.276T>C	c.(274-276)GAT>GAC	p.D92D	KLK8_uc002puq.1_Silent_p.D137D|KLK8_uc002pus.1_Intron|KLK8_uc002put.1_Intron|KLK8_uc002puu.1_Silent_p.D92D|KLK9_uc002puv.1_Intron	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein	92	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GCTCTGGGCCATCTTTATTCT	0.483													G	51503469	G	G	51503469	2	3	253	1	0	0	0	0	0	0	0	1	8410	214	8	4		4	KLK8	19	51503469	Silent	SNP	A	TCGA-74-6575-01A-11D-1845-08	228852	51503469	7625514	108	18185											
LILRA6	79168	broad.mit.edu	37	chr19	54744862	54744862	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctggggctgctggccagggCgctggaggaagtcacgttcc	17	12	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:54744862C>T	uc002qeu.1	-	5	924	c.800G>A	c.(799-801)CGC>CAC	p.R267H	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Missense_Mutation_p.R267H|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.R267H|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.R267H|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.R267H|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Missense_Mutation_p.R267H|LILRA6_uc010yeq.1_Missense_Mutation_p.R267H|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.R128H	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	267	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGGCCAGGGCGCTGGAGGAA	0.647													T	54744862	T	T	54744862	3	4	253	1	0	0	0	0	1	0	0	0	8789	768	27	1	661	1	LILRA6	19	54744862	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	3241393	54744862	4384121	109	18186											
KIR3DL1	3811	broad.mit.edu	37	chr19	55377847	55377847	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgctgtaatggaccaagaGcctgcgggggacagaacagt	15	9	0	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:55377847G>A	uc002qhl.3	+	8	1191	c.1128G>A	c.(1126-1128)GAG>GAA	p.E376E	KIR3DL2_uc010esh.2_Silent_p.E359E|KIR3DL2_uc002qho.3_Silent_p.E376E			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	376	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		TGGACCAAGAGCCTGCGGGGG	0.542													A	55377847	A	A	55377847	2	1	253	1	0	0	0	0	0	0	0	1	8320	962	34	3		3	KIR3DL1	19	55377847	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	632985	55377847	3751136	110	18187											
NLRP11	204801	broad.mit.edu	37	chr19	56313012	56313012	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aacatatttagggaaatggaCgtacagttgatactcaggta	10	5	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:56313012C>G	uc010ygf.1	-	7	2808	c.2097G>C	c.(2095-2097)ACG>ACC	p.T699T	NLRP11_uc002qlz.2_Silent_p.T546T|NLRP11_uc002qmb.2_Silent_p.T600T|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	699							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		GGGAAATGGACGTACAGTTGA	0.468													G	56313012	G	G	56313012	2	3	253	1	0	0	0	0	0	0	0	1	10473	523	19	5		5	NLRP11	19	56313012	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	935165	56313012	2815971	111	18188											
NLRP13	126204	broad.mit.edu	37	chr19	56407321	56407321	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcagtgaggtttacccgagtTtctgcagcctgcatgtcgac	11	11	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:56407321T>A	uc010ygg.1	-	11	3147	c.3122A>T	c.(3121-3123)AAA>ATA	p.K1041I		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	1041				KALKKSTCRLQKLG -> FKKTCTM (in Ref. 2; DAA01241).			ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TTACCCGAGTTTCTGCAGCCT	0.458													A	56407321	A	A	56407321	3	1	253	1	0	0	0	0	1	0	0	0	10475	1841	64	5	11	5	NLRP13	19	56407321	Missense_Mutation	SNP	T	TCGA-74-6575-01A-11D-1845-08	94309	56407321	2721662	112	18189											
ZSCAN22	342945	broad.mit.edu	37	chr19	58850663	58850663	+	Frame_Shift_Del	DEL	T	-	-													gctcagccctgatggttcacTtgcggatccacatcacggtg							TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chr19:58850663delT	uc002qsc.2	+	3	1594	c.1447delT	c.(1447-1449)TTGfs	p.L483fs	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	483	C2H2-type 8.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GATGGTTCACTTGCGGATCCA	0.577													-	58850663	-	-	58850663	7	5	253	1	0	1	0	1	0	0	0	0	18231	1606	56	0	1453	0	ZSCAN22	19	58850663	Frame_Shift_Del	DEL	T	TCGA-74-6575-01A-11D-1845-08	2443342	58850663	278320	113	18190											
CSF2RA	1438	broad.mit.edu	37	chrX	1407534	1407534	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaactgctttatccaaattcAggtaagcaagacagctcagg	8	9	2	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:1407534A>G	uc010nct.2	+	6	664	c.342A>G	c.(340-342)TCA>TCG	p.S114S	CSF2RA_uc011mhb.1_Silent_p.S114S|CSF2RA_uc004cpq.2_Silent_p.S114S|CSF2RA_uc004cpn.2_Silent_p.S114S|CSF2RA_uc004cpo.2_Silent_p.S114S|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_5'UTR|CSF2RA_uc004cpp.2_Silent_p.S114S|CSF2RA_uc010ncv.2_Silent_p.S114S|CSF2RA_uc004cpr.2_Silent_p.S114S	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	114	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	ATCCAAATTCAGGTAAGCAAG	0.443													G	1407534	G	G	1407534	2	3	253	1	0	0	0	0	0	0	0	1	3934	202	7	4		4	CSF2RA	23	1407534	Silent	SNP	A	TCGA-74-6575-01A-11D-1845-08		1407534	153863026	114	18191											
TLR7	51284	broad.mit.edu	37	chrX	12906437	12906437	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagggactggttaccagggcAgccagttctggaaaaccttt	12	9	1	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:12906437A>T	uc004cvc.2	+	3	2949	c.2810A>T	c.(2809-2811)CAG>CTG	p.Q937L		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	937	TIR.|Cytoplasmic (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	TTACCAGGGCAGCCAGTTCTG	0.443													T	12906437	T	T	12906437	3	4	253	1	0	0	0	0	1	0	0	0	15953	188	7	5	2816	5	TLR7	23	12906437	Missense_Mutation	SNP	A	TCGA-74-6575-01A-11D-1845-08	11498903	12906437	142364123	115	18192											
BMX	660	broad.mit.edu	37	chrX	15526512	15526512	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	attctagaagaacttcttctCaaaagatcacagcaaaagaa	5	8	4	4			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:15526512C>G	uc004cww.2	+	2	224	c.36C>G	c.(34-36)CTC>CTG	p.L12L	BMX_uc004cwx.3_Silent_p.L12L|BMX_uc004cwy.3_Silent_p.L12L	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	12	PH.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AACTTCTTCTCAAAAGATCAC	0.284													G	15526512	G	G	15526512	2	3	253	1	0	0	0	0	0	0	0	1	1473	813	29	5		5	BMX	23	15526512	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	2620075	15526512	139744048	116	18193											
CDKL5	6792	broad.mit.edu	37	chrX	18664128	18664128	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttctccccactaactagaCggtggatgtgatggcagaag	12	9	1	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:18664128C>T	uc004cym.2	+	19	2968	c.2715C>T	c.(2713-2715)GAC>GAT	p.D905D	CDKL5_uc004cyn.2_Silent_p.D905D|RS1_uc004cyo.2_Intron	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	905					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding	p.D905D(1)		ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					actaactagacggtggatgtg	0													T	18664128	T	T	18664128	2	4	253	1	0	0	0	0	0	0	0	1	3157	550	19	1		1	CDKL5	23	18664128	Silent	SNP	C	TCGA-74-6575-01A-11D-1845-08	3137616	18664128	136606432	117	18194											
UBQLN2	29978	broad.mit.edu	37	chrX	56590893	56590893	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctttgttcagagcatgctttCgaatcccgatctgatgaggc	10	10	2	3			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:56590893C>T	uc004dus.2	+	1	822	c.587C>T	c.(586-588)TCG>TTG	p.S196L	UBQLN2_uc011moq.1_Missense_Mutation_p.S196L	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	196						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						AGCATGCTTTCGAATCCCGAT	0.473													T	56590893	T	T	56590893	3	4	253	1	0	0	0	0	1	0	0	0	16894	893	31	2	589	2	UBQLN2	23	56590893	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	37926765	56590893	98679667	118	18195											
ATRX	546	broad.mit.edu	37	chrX	76918879	76918879	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aaaacatcttaccctttcttCtgtttctgcctttgacttct	3	12	5	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:76918879C>G	uc004ecp.3	-	12	4344	c.4112G>C	c.(4111-4113)AGA>ACA	p.R1371T	ATRX_uc004ecq.3_Missense_Mutation_p.R1333T|ATRX_uc004eco.3_Missense_Mutation_p.R1156T|ATRX_uc004ecr.2_Missense_Mutation_p.R1303T	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1371					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	ACCCTTTCTTCTGTTTCTGCC	0.289			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						G	76918879	G	G	76918879	3	3	253	1	0	0	0	0	1	0	0	0	1208	913	32	5	3462	5	ATRX	23	76918879	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	20327986	76918879	78351681	119	18196											
POU3F4	5456	broad.mit.edu	37	chrX	82763915	82763915	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cgccaacctctgatgagttgGaacagttcgccaaacaattc	8	12	1	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:82763915G>C	uc004eeg.2	+	1	647	c.583G>C	c.(583-585)GAA>CAA	p.E195Q		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	195	POU-specific.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGATGAGTTGGAACAGTTCGC	0.582													C	82763915	C	C	82763915	3	2	253	1	0	0	0	0	1	0	0	0	12277	1175	41	5	585	5	POU3F4	23	82763915	Missense_Mutation	SNP	G	TCGA-74-6575-01A-11D-1845-08	5845036	82763915	72506645	120	18197											
TAF7L	54457	broad.mit.edu	37	chrX	100538449	100538449	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	agtccatacctgagaaatgtCtgctgttttataaaaggttt	8	6	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:100538449C>G	uc004ehb.2	-	4	538	c.526G>C	c.(526-528)GAC>CAC	p.D176H	TAF7L_uc004eha.2_Missense_Mutation_p.D90H|TAF7L_uc004ehc.1_Missense_Mutation_p.D90H	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	176					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						TGAGAAATGTCTGCTGTTTTA	0.378													G	100538449	G	G	100538449	3	3	253	1	0	0	0	0	1	0	0	0	15530	913	32	5	902	5	TAF7L	23	100538449	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	17774534	100538449	54732111	121	18198											
TAF7L	54457	broad.mit.edu	37	chrX	100538507	100538507	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aggctttcaataacacaaggCaagtcaaccagcttagcagc	8	11	2	0			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:100538507C>G	uc004ehb.2	-	4	480	c.468G>C	c.(466-468)TTG>TTC	p.L156F	TAF7L_uc004eha.2_Missense_Mutation_p.L70F|TAF7L_uc004ehc.1_Missense_Mutation_p.L70F	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	156					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						TAACACAAGGCAAGTCAACCA	0.403													G	100538507	G	G	100538507	3	3	253	1	0	0	0	0	1	0	0	0	15530	709	25	5	960	5	TAF7L	23	100538507	Missense_Mutation	SNP	C	TCGA-74-6575-01A-11D-1845-08	58	100538507	54732053	122	18199											
KCNE1L	23630	broad.mit.edu	37	chrX	108868079	108868079	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggatgtagagataggcgtcGtcgcccttggcgctggtcac	15	10	1	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:108868079G>A	uc004eoh.2	-	1	315	c.171C>T	c.(169-171)GAC>GAT	p.D57D		NM_012282	NP_036414	Q9UJ90	KCE1L_HUMAN	potassium voltage-gated channel, Isk-related	57					regulation of heart contraction	voltage-gated potassium channel complex					0						GATAGGCGTCGTCGCCCTTGG	0.652													A	108868079	A	A	108868079	2	1	253	1	0	0	0	0	0	0	0	1	8022	1136	40	1		1	KCNE1L	23	108868079	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	8329572	108868079	46402481	123	18200											
XPNPEP2	7512	broad.mit.edu	37	chrX	128890500	128890500	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcaagctgtcctcagatgagAtgtacctgctggactctggg	13	10	2	2			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:128890500A>C	uc004eut.1	+	14	1580	c.1336A>C	c.(1336-1338)ATG>CTG	p.M446L		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	446					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						CTCAGATGAGATGTACCTGCT	0.592													C	128890500	C	C	128890500	3	2	253	1	0	0	0	0	1	0	0	0	17440	333	12	5	1390	5	XPNPEP2	23	128890500	Missense_Mutation	SNP	A	TCGA-74-6575-01A-11D-1845-08	20022421	128890500	26380060	124	18201											
MAGEC1	9947	broad.mit.edu	37	chrX	140994261	140994261	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgagtattttccagagttcTcctgagagtgctcaaagtac	9	8	2	3	rs58302943	byFrequency	TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:140994261T>C	uc004fbt.2	+	4	1357	c.1071T>C	c.(1069-1071)TCT>TCC	p.S357S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	357							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGAGTTCTCCTGAGAGTG	0.468										HNSCC(15;0.026)			C	140994261	C	C	140994261	2	2	253	1	0	0	0	0	0	0	0	1	9180	1538	54	4		4	MAGEC1	23	140994261	Silent	SNP	T	TCGA-74-6575-01A-11D-1845-08	12103761	140994261	14276299	125	18202											
FLNA	2316	broad.mit.edu	37	chrX	153592699	153592699	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aactctgctggcttgttgacGgccacacctgtcttctccaa	8	14	3	1			TCGA-74-6575-01A-11D-1845-08	TCGA-74-6575-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4ec96d6-d7fc-4892-9a36-80802f387a12	bbf0cfd3-ee48-46de-8e5c-15f89207dee9	g.chrX:153592699G>A	uc004fkk.2	-	14	2313	c.2064C>T	c.(2062-2064)GCC>GCT	p.A688A	FLNA_uc010nuu.1_Silent_p.A688A	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	688	Filamin 5.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTTGTTGACGGCCACACCTG	0.637													A	153592699	A	A	153592699	2	1	253	1	0	0	0	0	0	0	0	1	5933	1103	39	2		2	FLNA	23	153592699	Silent	SNP	G	TCGA-74-6575-01A-11D-1845-08	12598438	153592699	1677861	126	18203											
KIAA0090	23065	broad.mit.edu	37	chr1	19557342	19557342	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggacatgccttcctacctttCgaagccgatatccacacagc	7	15	0	0			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr1:19557342C>T	uc001bbo.2	-	17	2103	c.2060G>A	c.(2059-2061)CGA>CAA	p.R687Q	KIAA0090_uc001bbp.2_Missense_Mutation_p.R686Q|KIAA0090_uc001bbq.2_Missense_Mutation_p.R686Q|KIAA0090_uc001bbr.2_Missense_Mutation_p.R665Q	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	687	Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		TCCTACCTTTCGAAGCCGATA	0.502													T	19557342	T	T	19557342	3	4	254	1	0	0	0	0	1	0	0	0	8153	884	31	2	949	2	KIAA0090	1	19557342	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08		19557342	229693279	1	18204											
HRNR	388697	broad.mit.edu	37	chr1	152185734	152185734	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accagaggactgtcctgagcCagacccatgttggccgtagc	12	13	0	3			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr1:152185734C>T	uc001ezt.1	-	3	8447	c.8371G>A	c.(8371-8373)GGC>AGC	p.G2791S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2791	30.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGAGCCAGACCCATGT	0.557													T	152185734	T	T	152185734	3	4	254	1	0	0	0	0	1	0	0	0	7359	594	21	3	185	3	HRNR	1	152185734	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	132628392	152185734	97064887	2	18205											
SOX13	9580	broad.mit.edu	37	chr1	204092264	204092265	+	Missense_Mutation	DNP	CC	AA	AA													tcatcagcctggactcatccCcagccaaggagcggctggag							TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr1:204092264_204092265CC>AA	uc001ham.2	+	11	1754_1755	c.1159_1160CC>AA	c.(1159-1161)CCA>AAA	p.P387K	SOX13_uc010pqp.1_Missense_Mutation_p.P386K|SOX13_uc010pqq.1_Missense_Mutation_p.P254K	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	387					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			GGACTCATCCCCAGCCAAGGAG	0.634													AA	204092265	AA	AA	204092264	3	1	254	1	0	0	0	0	1	0	0	0	14944	623	22	5	1197	5	SOX13	1	204092264	Missense_Mutation	DNP	CC	TCGA-74-6577-01A-11D-1845-08	51906530	204092264	45158357	3	18206											
REN	5972	broad.mit.edu	37	chr1	204125330	204125330	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aacagcctcttcttggctccCaaggcctccatgagcttctc	7	16	3	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr1:204125330C>A	uc001haq.2	-	8	980	c.936G>T	c.(934-936)TTG>TTT	p.L312F		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	312					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	TCTTGGCTCCCAAGGCCTCCA	0.567													A	204125330	A	A	204125330	3	1	254	1	0	0	0	0	1	0	0	0	13224	593	21	5	296	5	REN	1	204125330	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	33066	204125330	45125291	4	18207											
GLI2	2736	broad.mit.edu	37	chr2	121748070	121748070	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcactcgagtttgttctcggGtgctctgagccccagcctcc	10	15	3	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr2:121748070G>T	uc010flp.2	+	13	4610	c.4580G>T	c.(4579-4581)GGT>GTT	p.G1527V	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.G1199V|GLI2_uc002tmu.3_Missense_Mutation_p.G1182V	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1527					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				TTGTTCTCGGGTGCTCTGAGC	0.622													T	121748070	T	T	121748070	3	4	254	1	0	0	0	0	1	0	0	0	6438	1261	44	5	4630	5	GLI2	2	121748070	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08		121748070	121451303	5	18208											
SEMA3G	56920	broad.mit.edu	37	chr3	52475334	52475334	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggttcgagccaccatcgggCgaggggaccgtctccgagaa	15	12	1	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr3:52475334C>T	uc003dea.1	-	7	759	c.759G>A	c.(757-759)TCG>TCA	p.S253S		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	253	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CACCATCGGGCGAGGGGACCG	0.617													T	52475334	T	T	52475334	2	4	254	1	0	0	0	0	0	0	0	1	14030	755	27	1		1	SEMA3G	3	52475334	Silent	SNP	C	TCGA-74-6577-01A-11D-1845-08		52475334	145547096	6	18209											
UGT2B4	7363	broad.mit.edu	37	chr4	70346533	70346533	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgcttggctcctttatggCgcatgacaaattcaatccag	10	10	1	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr4:70346533C>T	uc003hek.3	-	6	1453	c.1406G>A	c.(1405-1407)CGC>CAC	p.R469H	UGT2B4_uc011cap.1_Missense_Mutation_p.R333H|UGT2B4_uc003hel.3_3'UTR	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	469					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TCCTTTATGGCGCATGACAAA	0.473													T	70346533	T	T	70346533	3	4	254	1	0	0	0	0	1	0	0	0	16958	768	27	1	184	1	UGT2B4	4	70346533	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08		70346533	120807743	7	18210											
NPR3	4883	broad.mit.edu	37	chr5	32774858	32774858	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgatgccatcctcctctaCgtcttggctctacatgaagt	7	14	3	1	rs140897654	by1000genomes	TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr5:32774858C>T	uc003jhv.2	+	4	1322	c.1104C>T	c.(1102-1104)TAC>TAT	p.Y368Y	NPR3_uc010iuo.2_Silent_p.Y152Y|NPR3_uc011cnz.1_Silent_p.Y152Y|NPR3_uc003jhu.2_Silent_p.Y368Y	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	368	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	TCCTCCTCTACGTCTTGGCTC	0.443													T	32774858	T	T	32774858	2	4	254	1	0	0	0	0	0	0	0	1	10596	547	19	1		1	NPR3	5	32774858	Silent	SNP	C	TCGA-74-6577-01A-11D-1845-08		32774858	148140402	8	18211											
STK32A	202374	broad.mit.edu	37	chr5	146750222	146750222	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttctcccttaagagaccGtatcatattcgctccagtac	5	13	2	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr5:146750222G>A	uc010jgn.1	+	9	946	c.666G>A	c.(664-666)CCG>CCA	p.P222P	STK32A_uc003lom.2_Silent_p.P222P|STK32A_uc011dbw.1_Silent_p.P222P	NM_001112724	NP_001106195	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A isoform 1	222	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAAGAGACCGTATCATATTC	0.378													A	146750222	A	A	146750222	2	1	254	1	0	0	0	0	0	0	0	1	15296	1132	40	1		1	STK32A	5	146750222	Silent	SNP	G	TCGA-74-6577-01A-11D-1845-08	113975364	146750222	34165038	9	18212											
ABLIM3	22885	broad.mit.edu	37	chr5	148619445	148619445	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcacctcaccactactacCgctctggtaaggaaggggga	11	13	3	0			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr5:148619445C>T	uc003lpy.2	+	13	1449	c.1198C>T	c.(1198-1200)CGC>TGC	p.R400C	ABLIM3_uc003lpz.1_Missense_Mutation_p.R400C|ABLIM3_uc003lqa.1_Missense_Mutation_p.R346C|ABLIM3_uc003lqb.2_Missense_Mutation_p.R338C|ABLIM3_uc003lqc.1_Missense_Mutation_p.R400C|ABLIM3_uc003lqd.1_Missense_Mutation_p.R338C|ABLIM3_uc003lqf.2_Missense_Mutation_p.R338C|ABLIM3_uc003lqe.1_Missense_Mutation_p.R338C	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	400					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACTACTACCGCTCTGGTAA	0.647													T	148619445	T	T	148619445	3	4	254	1	0	0	0	0	1	0	0	0	96	652	23	2	1244	2	ABLIM3	5	148619445	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	1869223	148619445	32295815	10	18213											
MYO6	4646	broad.mit.edu	37	chr6	76566831	76566834	+	Frame_Shift_Del	DEL	AGCA	-	-													tagggtacctctgaaagtggAgcaagcaaacaatgctcgtg							TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr6:76566831_76566834delAGCA	uc003pih.1	+	13	1520_1523	c.1241_1244delAGCA	c.(1240-1245)GAGCAAfs	p.E414fs	MYO6_uc003pig.1_Frame_Shift_Del_p.E414fs|MYO6_uc003pii.1_Frame_Shift_Del_p.E414fs	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	414_415	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		CTGAAAGTGGAGCAAGCAAACAAT	0.377													-	76566834	-	-	76566831	7	5	254	1	0	1	0	1	0	0	0	0	10081	304	11	0	1287	0	MYO6	6	76566831	Frame_Shift_Del	DEL	AGCA	TCGA-74-6577-01A-11D-1845-08		76566831	94548236	11	18214											
PKD1L1	168507	broad.mit.edu	37	chr7	47869692	47869692	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggagagggacagcaggtgCagccactgcacacattgctc	13	12	0	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr7:47869692C>T	uc003tny.1	-	43	6504	c.6504G>A	c.(6502-6504)CTG>CTA	p.L2168L	C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_5'Flank	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2168	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ACAGCAGGTGCAGCCACTGCA	0.577													T	47869692	T	T	47869692	2	4	254	1	0	0	0	0	0	0	0	1	11964	697	25	3		3	PKD1L1	7	47869692	Silent	SNP	C	TCGA-74-6577-01A-11D-1845-08		47869692	111268971	12	18215											
ZP3	7784	broad.mit.edu	37	chr7	76054396	76054396	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagccatcctgagacgtccGtacagcccgtactggtggag	12	14	0	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr7:76054396G>A	uc003ufd.3	+	1	125	c.115G>A	c.(115-117)GTA>ATA	p.V39I	ZP3_uc003ufc.3_5'UTR	NM_001110354	NP_001103824	P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 isoform 1	39	Extracellular (Potential).				binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding				0						TGAGACGTCCGTACAGCCCGT	0.592													A	76054396	A	A	76054396	3	1	254	1	0	0	0	0	1	0	0	0	18214	1145	40	1	117	1	ZP3	7	76054396	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08	28184704	76054396	83084267	13	18216											
RBM28	55131	broad.mit.edu	37	chr7	127954955	127954956	+	Missense_Mutation	DNP	GG	TT	TT													ccgcctttctcttctgctctGggggcaccttgctttgttcc							TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr7:127954955_127954956GG>TT	uc003vmp.2	-	17	2021_2022	c.1906_1907CC>AA	c.(1906-1908)CCA>AAA	p.P636K	RBM28_uc003vmo.2_Missense_Mutation_p.P178K|RBM28_uc011koj.1_Missense_Mutation_p.P495K	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	636					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						CTTCTGCTCTGGGGGCACCTTG	0.564													TT	127954956	TT	TT	127954955	3	4	254	1	0	0	0	0	1	0	0	0	13128	1348	47	5	384	5	RBM28	7	127954955	Missense_Mutation	DNP	GG	TCGA-74-6577-01A-11D-1845-08	51900559	127954955	31183708	14	18217											
MLL3	58508	broad.mit.edu	37	chr7	151945253	151945253	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taactttatagatttgcctcCttggtatgaaacatctttca	5	8	2	2			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr7:151945253C>T	uc003wla.2	-	14	2485	c.2266G>A	c.(2266-2268)GGA>AGA	p.G756R		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	756					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GATTTGCCTCCTTGGTATGAA	0.393			N		medulloblastoma								T	151945253	T	T	151945253	3	4	254	1	0	0	0	0	1	0	0	0	9622	690	24	3	12653	3	MLL3	7	151945253	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	23990298	151945253	7193410	15	18218											
PTPRN2	5799	broad.mit.edu	37	chr7	157985120	157985120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaggtggcgtcggagggCgttggccagggcagcaccgc	21	11	0	0			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr7:157985120C>T	uc003wno.2	-	5	569	c.448G>A	c.(448-450)GCC>ACC	p.A150T	PTPRN2_uc003wnp.2_Missense_Mutation_p.A133T|PTPRN2_uc003wnq.2_Missense_Mutation_p.A150T|PTPRN2_uc003wnr.2_Missense_Mutation_p.A112T|PTPRN2_uc011kwa.1_Missense_Mutation_p.A173T	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	150	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CGTCGGAGGGCGTTGGCCAGG	0.652													T	157985120	T	T	157985120	3	4	254	1	0	0	0	0	1	0	0	0	12808	768	27	1	2675	1	PTPRN2	7	157985120	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	6039867	157985120	1153543	16	18219											
VPS13B	157680	broad.mit.edu	37	chr8	100821739	100821739	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcatcaaggttcagcaacTcaatggagtacaaaaacagg	8	9	4	0			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr8:100821739T>C	uc003yiv.2	+	44	8264	c.8153T>C	c.(8152-8154)CTC>CCC	p.L2718P	VPS13B_uc003yiw.2_Missense_Mutation_p.L2693P	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2718					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTTCAGCAACTCAATGGAGTA	0.383													C	100821739	C	C	100821739	3	2	254	1	0	0	0	0	1	0	0	0	17187	1551	54	4	8517	4	VPS13B	8	100821739	Missense_Mutation	SNP	T	TCGA-74-6577-01A-11D-1845-08		100821739	45542283	17	18220											
PRUNE2	158471	broad.mit.edu	37	chr9	79324782	79324782	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catcatgatcttctttaccaAatgcactccaggctgggaat	7	11	3	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr9:79324782A>T	uc010mpk.2	-	8	2532	c.2408T>A	c.(2407-2409)TTT>TAT	p.F803Y		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	803					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TTCTTTACCAAATGCACTCCA	0.517													T	79324782	T	T	79324782	3	4	254	1	0	0	0	0	1	0	0	0	12641	14	1	5	6906	5	PRUNE2	9	79324782	Missense_Mutation	SNP	A	TCGA-74-6577-01A-11D-1845-08		79324782	61888649	18	18221											
SVEP1	79987	broad.mit.edu	37	chr9	113171158	113171158	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcttggcagacaaatacaGgacttccgactgacttatag	10	9	0	2			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr9:113171158G>A	uc010mtz.2	-	38	7059	c.6722C>T	c.(6721-6723)CCT>CTT	p.P2241L	SVEP1_uc010mty.2_Missense_Mutation_p.P167L	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2241	Sushi 14.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GACAAATACAGGACTTCCGAC	0.507													A	113171158	A	A	113171158	3	1	254	1	0	0	0	0	1	0	0	0	15417	1000	35	3	4037	3	SVEP1	9	113171158	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08	33846376	113171158	28042273	19	18222											
C9orf84	158401	broad.mit.edu	37	chr9	114475419	114475419	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tttaatgagaaaatgtttttCaccgtctgagtccattctta	6	7	3	2			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr9:114475419C>G	uc004bfr.2	-	16	2392	c.2257G>C	c.(2257-2259)GAA>CAA	p.E753Q	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.E714Q|C9orf84_uc010mug.2_Missense_Mutation_p.E664Q	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	753										ovary(2)	2						AAATGTTTTTCACCGTCTGAG	0.259													G	114475419	G	G	114475419	3	3	254	1	0	0	0	0	1	0	0	0	2500	835	29	5	2121	5	C9orf84	9	114475419	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	1304261	114475419	26738012	20	18223											
PAPPA	5069	broad.mit.edu	37	chr9	118982397	118982397	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcccacctatagatggccaTttctttgaaaggtgagtgtg	10	8	1	3			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr9:118982397T>C	uc004bjn.2	+	5	2481	c.2100T>C	c.(2098-2100)CAT>CAC	p.H700H	PAPPA_uc011lxp.1_Silent_p.H395H|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	700					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TAGATGGCCATTTCTTTGAAA	0.547													C	118982397	C	C	118982397	2	2	254	1	0	0	0	0	0	0	0	1	11432	1490	52	4		4	PAPPA	9	118982397	Silent	SNP	T	TCGA-74-6577-01A-11D-1845-08	4506978	118982397	22231034	21	18224											
PTEN	5728	broad.mit.edu	37	chr10	89720855	89720856	+	Frame_Shift_Ins	INS	-	A	A													taaagacaaagccaaccgatINSacttttctccaaattttaag							TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr10:89720855_89720856insA	uc001kfb.2	+	9	2037_2038	c.1006_1007insA	c.(1006-1008)TACfs	p.Y336fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	336	C2 tensin-type.			Y->F: Significantly lower phosphatase activity, reduced protein stability and decreased growth-inhibitory effect.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.Y336*(3)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.R335fs*8(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.R335fs*4(1)|p.R335fs*7(1)|p.W274_F341del(1)|p.Y336F(1)|p.D326_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGCCAACCGATACTTTTCTCCA	0.337		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89720856	A	A	89720855	7	5	254	1	0	1	1	0	0	0	0	0	12738	1406	49	0	1036	0	PTEN	10	89720855	Frame_Shift_Ins	INS	-	TCGA-74-6577-01A-11D-1845-08		89720855	45813892	22	18225											
USH1C	10083	broad.mit.edu	37	chr11	17519716	17519716	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccttattcttaccccgcccTgattccaggccttctgcagg	8	16	2	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr11:17519716T>C	uc001mnf.2	-	19	1692	c.1583A>G	c.(1582-1584)CAG>CGG	p.Q528R	USH1C_uc001mne.2_Missense_Mutation_p.Q828R|USH1C_uc009yhb.2_Missense_Mutation_p.Q509R|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.Q492R	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	528	PDZ 3.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						TACCCCGCCCTGATTCCAGGC	0.577													C	17519716	C	C	17519716	3	2	254	1	0	0	0	0	1	0	0	0	17031	1580	55	4	232	4	USH1C	11	17519716	Missense_Mutation	SNP	T	TCGA-74-6577-01A-11D-1845-08		17519716	117486800	23	18226											
PRG2	5553	broad.mit.edu	37	chr11	57155245	57155245	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctcgggtacacagggccaCgcagtgaccaccgcgggacc	13	16	0	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr11:57155245C>T	uc001njz.2	-	4	619	c.592G>A	c.(592-594)GTG>ATG	p.V198M	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.V198M|PRG2_uc001nkb.2_Missense_Mutation_p.V198M|PRG2_uc001nkd.2_Missense_Mutation_p.V187M|PRG2_uc001nkc.2_Missense_Mutation_p.V198M|PRG2_uc001nke.2_Missense_Mutation_p.V478M	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	198	C-type lectin.				defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	CACAGGGCCACGCAGTGACCA	0.617													T	57155245	T	T	57155245	3	4	254	1	0	0	0	0	1	0	0	0	12479	536	19	1	84	1	PRG2	11	57155245	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	39635529	57155245	77851271	24	18227											
KRAS	3845	broad.mit.edu	37	chr12	25398284	25398284	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcactcttgcctacgccaCcagctccaactaccacaagt	6	17	1	0	rs121913529		TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr12:25398284C>T	uc001rgp.1	-	2	216	c.35G>A	c.(34-36)GGT>GAT	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			T	25398284	T	T	25398284	3	4	254	1	0	0	0	0	1	0	0	0	8438	507	18	3	671	3	KRAS	12	25398284	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08		25398284	108453611	25	18228											
AQP2	359	broad.mit.edu	37	chr12	50344911	50344911	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctgctgggggctgtggccGgagccgctctgctccatgag	17	12	1	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr12:50344911G>A	uc001rvn.2	+	1	388	c.298G>A	c.(298-300)GGA>AGA	p.G100R		NM_000486	NP_000477	P41181	AQP2_HUMAN	aquaporin 2	100	Helical; (Potential).		G -> R (in ANDI).		cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			ovary(2)	2						GGCTGTGGCCGGAGCCGCTCT	0.647													A	50344911	A	A	50344911	3	1	254	1	0	0	0	0	1	0	0	0	826	1117	39	2	300	2	AQP2	12	50344911	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08	24946627	50344911	83506984	26	18229											
NACA	4666	broad.mit.edu	37	chr12	57108166	57108166	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttccgtgccttcttttcacTccgactctgttttgctttac	5	14	3	0			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr12:57108166T>C	uc001slz.2	-	4	563	c.214A>G	c.(214-216)AGT>GGT	p.S72G	NACA_uc001sly.2_Missense_Mutation_p.S72G|NACA_uc009zoy.1_Missense_Mutation_p.S1935G|NACA_uc001smc.2_Missense_Mutation_p.S72G|NACA_uc001sma.2_Missense_Mutation_p.S782G|NACA_uc001smb.2_Missense_Mutation_p.S72G|NACA_uc010squ.1_Intron	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	72	Required for DNA-binding (By similarity).|NAC-A/B.				interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						TTCTTTTCACTCCGACTCTGT	0.358			T	BCL6	NHL								C	57108166	C	C	57108166	3	2	254	1	0	0	0	0	1	0	0	0	10133	1551	54	4	453	4	NACA	12	57108166	Missense_Mutation	SNP	T	TCGA-74-6577-01A-11D-1845-08	6763255	57108166	76743729	27	18230											
OR4K2	390431	broad.mit.edu	37	chr14	20345324	20345324	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aagtaaagatagccatgaggAaactgaaaaataggtttcta	9	4	1	3			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr14:20345324A>G	uc001vwh.1	+	1	898	c.898A>G	c.(898-900)AAA>GAA	p.K300E		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGCCATGAGGAAACTGAAAAA	0.348													G	20345324	G	G	20345324	3	3	254	1	0	0	0	0	1	0	0	0	11072	247	9	4	900	4	OR4K2	14	20345324	Missense_Mutation	SNP	A	TCGA-74-6577-01A-11D-1845-08		20345324	87004216	28	18231											
TTC5	91875	broad.mit.edu	37	chr14	20760171	20760171	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgctgaattcggtgaagccGcaggttgggctcaggaatgg	17	7	1	2			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr14:20760171G>A	uc001vwt.2	-	9	1231	c.1174C>T	c.(1174-1176)CGG>TGG	p.R392W	TTC5_uc001vwu.2_Missense_Mutation_p.R249W	NM_138376	NP_612385	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	392					DNA repair	cytoplasm|nucleus	binding			ovary(1)	1	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		CGGTGAAGCCGCAGGTTGGGC	0.453													A	20760171	A	A	20760171	3	1	254	1	0	0	0	0	1	0	0	0	16708	1086	38	1	156	1	TTC5	14	20760171	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08	414847	20760171	86589369	29	18232											
LTB4R2	56413	broad.mit.edu	37	chr14	24779987	24779987	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctggggctgcctggcaacggCttcgtggtgtggagcttggc	18	10	0	0			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr14:24779987C>A	uc001woq.1	+	1	1827	c.210C>A	c.(208-210)GGC>GGA	p.G70G	CIDEB_uc001won.2_5'Flank|CIDEB_uc001woo.2_5'UTR|CIDEB_uc001wop.2_5'UTR|LTB4R2_uc010alo.2_Silent_p.G39G|LTB4R2_uc001wor.2_Silent_p.G39G|LTB4R_uc001wos.2_5'Flank|LTB4R_uc010alp.2_5'Flank	NM_019839	NP_062813	Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	70	Helical; Name=1; (Potential).				chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane					0				GBM - Glioblastoma multiforme(265;0.018)		CTGGCAACGGCTTCGTGGTGT	0.726													A	24779987	A	A	24779987	2	1	254	1	0	0	0	0	0	0	0	1	9072	784	28	5		5	LTB4R2	14	24779987	Silent	SNP	C	TCGA-74-6577-01A-11D-1845-08	4019816	24779987	82569553	30	18233											
BAZ1A	11177	broad.mit.edu	37	chr14	35331298	35331298	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagtttcttcgacaaaatatCgatccttgacatatgcaaag	6	9	1	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr14:35331298C>T	uc001wsk.2	-	3	912	c.344G>A	c.(343-345)CGA>CAA	p.R115Q	BAZ1A_uc001wsl.2_Missense_Mutation_p.R115Q|BAZ1A_uc001wsm.1_Missense_Mutation_p.R115Q	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	115	WAC.|Required for association with the CHRAC1/POLE3 complex.|Required for interaction with NCOR1.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		GACAAAATATCGATCCTTGAC	0.358													T	35331298	T	T	35331298	3	4	254	1	0	0	0	0	1	0	0	0	1329	884	31	2	4426	2	BAZ1A	14	35331298	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	10551311	35331298	72018242	31	18234											
GJD2	57369	broad.mit.edu	37	chr15	35045056	35045056	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacttggataatgtagaagcGggagatgccttcctgccttc	11	10	0	2			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr15:35045056G>A	uc001zis.1	-	2	589	c.589C>T	c.(589-591)CGC>TGC	p.R197C	uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	197	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		ATGTAGAAGCGGGAGATGCCT	0.483													A	35045056	A	A	35045056	3	1	254	1	0	0	0	0	1	0	0	0	6417	1116	39	2	380	2	GJD2	15	35045056	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08		35045056	67486336	32	18235											
BAHD1	22893	broad.mit.edu	37	chr15	40750942	40750942	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgaggctgatgagctaccGcctgacctgcccaagccccc	11	16	0	4			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr15:40750942G>A	uc001zlu.2	+	2	350	c.279G>A	c.(277-279)CCG>CCA	p.P93P	BAHD1_uc001zlt.2_Silent_p.P93P|BAHD1_uc010bbp.1_Silent_p.P93P|BAHD1_uc001zlv.2_Silent_p.P93P	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	93					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		ATGAGCTACCGCCTGACCTGC	0.662													A	40750942	A	A	40750942	2	1	254	1	0	0	0	0	0	0	0	1	1297	1074	38	1		1	BAHD1	15	40750942	Silent	SNP	G	TCGA-74-6577-01A-11D-1845-08	5705886	40750942	61780450	33	18236											
STRC	161497	broad.mit.edu	37	chr15	43893602	43893602	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaaagtgttacctgagtggTgctccagccatctatctgcc	10	11	2	1	rs141809944		TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr15:43893602T>C	uc001zsf.2	-	24	4771	c.4693A>G	c.(4693-4695)ACC>GCC	p.T1565A	STRC_uc010bdl.2_Missense_Mutation_p.T792A|STRC_uc001zse.2_Missense_Mutation_p.T83A	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1565					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ACCTGAGTGGTGCTCCAGCCA	0.522													C	43893602	C	C	43893602	3	2	254	1	0	0	0	0	1	0	0	0	15327	1696	59	4	658	4	STRC	15	43893602	Missense_Mutation	SNP	T	TCGA-74-6577-01A-11D-1845-08	3142660	43893602	58637790	34	18237											
SEC14L5	9717	broad.mit.edu	37	chr16	5058451	5058451	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagatcctggaaggagagtcGgtcatcacctgggactttga	14	8	2	3			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr16:5058451G>A	uc002cye.2	+	14	1782	c.1602G>A	c.(1600-1602)TCG>TCA	p.S534S		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	534	GOLD.					integral to membrane|intracellular	transporter activity				0						AAGGAGAGTCGGTCATCACCT	0.642													A	5058451	A	A	5058451	2	1	254	1	0	0	0	0	0	0	0	1	13985	1103	39	2		2	SEC14L5	16	5058451	Silent	SNP	G	TCGA-74-6577-01A-11D-1845-08		5058451	85296302	35	18238											
APPBP2	10513	broad.mit.edu	37	chr17	58603208	58603208	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaggagcggatgtctcggcGggagcggatgtagttgtcca	17	8	1	0			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr17:58603208G>A	uc002iys.1	-	1	373	c.85C>T	c.(85-87)CGC>TGC	p.R29C	APPBP2_uc010ddl.1_5'UTR	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	29					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			ATGTCTCGGCGGGAGCGGATG	0.562													A	58603208	A	A	58603208	3	1	254	1	0	0	0	0	1	0	0	0	816	1116	39	2	1724	2	APPBP2	17	58603208	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08		58603208	22592002	36	18239											
CD300LD	100131439	broad.mit.edu	37	chr17	72576247	72576247	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaagtgggtgctcttgagcGgggacctgtgggaacacggt	19	7	1	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr17:72576247G>A	uc002jkz.2	-	4	508	c.479C>T	c.(478-480)CCG>CTG	p.P160L		NM_001115152	NP_001108624	Q6UXZ3	CLM4_HUMAN	CD300 molecule-like family member d precursor	160	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity				0						GCTCTTGAGCGGGGACCTGTG	0.572													A	72576247	A	A	72576247	3	1	254	1	0	0	0	0	1	0	0	0	3000	1116	39	2	109	2	CD300LD	17	72576247	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08	13973039	72576247	8618963	37	18240											
SERPINB7	8710	broad.mit.edu	37	chr18	61471645	61471645	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttgatgaatccaaagcagatCtctctgggattgcttcgggg	12	8	2	3			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr18:61471645C>T	uc002ljl.2	+	8	1015	c.919C>T	c.(919-921)CTC>TTC	p.L307F	SERPINB7_uc002ljm.2_Missense_Mutation_p.L307F|SERPINB7_uc010xet.1_Missense_Mutation_p.L290F|SERPINB7_uc010dqg.2_Missense_Mutation_p.L307F	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	307					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				CAAAGCAGATCTCTCTGGGAT	0.433													T	61471645	T	T	61471645	3	4	254	1	0	0	0	0	1	0	0	0	14106	913	32	3	945	3	SERPINB7	18	61471645	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08		61471645	16605603	38	18241											
ATP9B	374868	broad.mit.edu	37	chr18	77037059	77037059	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttttatttggcagtttgcGtgtgaacttggacatgggca	14	5	0	1	rs149013492		TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr18:77037059G>A	uc002lmx.2	+	13	1288	c.1274G>A	c.(1273-1275)CGT>CAT	p.R425H	ATP9B_uc002lmv.1_RNA|ATP9B_uc002lmw.1_Missense_Mutation_p.R425H|ATP9B_uc002lmy.1_RNA|ATP9B_uc002lmz.1_Missense_Mutation_p.R119H	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	425	Helical; (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		GGCAGTTTGCGTGTGAACTTG	0.493													A	77037059	A	A	77037059	3	1	254	1	0	0	0	0	1	0	0	0	1199	1145	40	1	1324	1	ATP9B	18	77037059	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08	15565414	77037059	1040189	39	18242											
S1PR2	9294	broad.mit.edu	37	chr19	10335447	10335447	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggttttccaccacaatggcGcaacagaggatgacgatgaa	11	9	0	3			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr19:10335447G>A	uc002mnl.2	-	2	246	c.135C>T	c.(133-135)TGC>TGT	p.C45C		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	45	Helical; Name=1; (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						CCACAATGGCGCAACAGAGGA	0.567													A	10335447	A	A	10335447	2	1	254	1	0	0	0	0	0	0	0	1	13794	1079	38	1		1	S1PR2	19	10335447	Silent	SNP	G	TCGA-74-6577-01A-11D-1845-08		10335447	48793536	40	18243											
CILP2	148113	broad.mit.edu	37	chr19	19655680	19655680	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggcttctccgccaaccccCgtgcctggggccgctttgac	11	19	1	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr19:19655680C>T	uc002nmv.3	+	8	2411	c.2326C>T	c.(2326-2328)CGT>TGT	p.R776C	CILP2_uc002nmw.3_Missense_Mutation_p.R782C	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	776						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CGCCAACCCCCGTGCCTGGGG	0.711													T	19655680	T	T	19655680	3	4	254	1	0	0	0	0	1	0	0	0	3430	652	23	2	2356	2	CILP2	19	19655680	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	9320233	19655680	39473303	41	18244											
LILRA3	11026	broad.mit.edu	37	chr19	54803127	54803127	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttgggctcacggggcccaCggagaagatggcccgggatg	17	11	1	2			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr19:54803127C>T	uc002qfd.2	-	4	615	c.550G>A	c.(550-552)GTG>ATG	p.V184M	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	184	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACGGGGCCCACGGAGAAGATG	0.567													T	54803127	T	T	54803127	3	4	254	1	0	0	0	0	1	0	0	0	8786	536	19	1	785	1	LILRA3	19	54803127	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	35147447	54803127	4325856	42	18245											
NLRP4	147945	broad.mit.edu	37	chr19	56382302	56382302	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtgccaatgtcctgaaggacGaaggactgaaaactctctgc	11	10	1	2	rs140263319	by1000genomes	TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr19:56382302G>A	uc002qmd.3	+	7	2886	c.2464G>A	c.(2464-2466)GAA>AAA	p.E822K	NLRP4_uc002qmf.2_Missense_Mutation_p.E747K|NLRP4_uc010etf.2_Missense_Mutation_p.E597K	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	822	LRR 5.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCTGAAGGACGAAGGACTGAA	0.512													A	56382302	A	A	56382302	3	1	254	1	0	0	0	0	1	0	0	0	10479	1059	37	2	2486	2	NLRP4	19	56382302	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08	1579175	56382302	2746681	43	18246											
RBCK1	10616	broad.mit.edu	37	chr20	390566	390566	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacccgagcagtggcgggcGgggatgaacaggtggcaatg	18	9	1	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr20:390566G>A	uc002wdp.3	+	2	757	c.64G>A	c.(64-66)GGG>AGG	p.G22R	RBCK1_uc010zpl.1_Missense_Mutation_p.G22R|RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Intron|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Intron|RBCK1_uc002wdo.2_RNA	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	22	Interaction with IRF3.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				AGTGGCGGGCGGGGATGAACA	0.582													A	390566	A	A	390566	3	1	254	1	0	0	0	0	1	0	0	0	13107	1116	39	2	89	2	RBCK1	20	390566	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08		390566	62634954	44	18247											
COL18A1	80781	broad.mit.edu	37	chr21	46897864	46897864	+	Frame_Shift_Del	DEL	A	-	-													gggagggacggcacccctggAagggacggcgagccggtgag							TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chr21:46897864delA	uc011afs.1	+	7	2472	c.2451delA	c.(2449-2451)GGAfs	p.G817fs	COL18A1_uc002zhg.2_Frame_Shift_Del_p.G402fs|COL18A1_uc002zhi.2_Frame_Shift_Del_p.G582fs	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	817	Triple-helical region 2 (COL2).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GCACCCCTGGAAGGGACGGCG	0.726													-	46897864	-	-	46897864	7	5	254	1	0	1	0	1	0	0	0	0	3675	233	9	0	2591	0	COL18A1	21	46897864	Frame_Shift_Del	DEL	A	TCGA-74-6577-01A-11D-1845-08		46897864	1232031	45	18248											
FAM47C	442444	broad.mit.edu	37	chrX	37027712	37027712	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccggagcctcccaagactcGcatatctaatctccgctcgg	8	17	2	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chrX:37027712G>A	uc004ddl.1	+	1	1243	c.1229G>A	c.(1228-1230)CGC>CAC	p.R410H		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	410										ovary(3)	3						CCCAAGACTCGCATATCTAAT	0.607													A	37027712	A	A	37027712	3	1	254	1	0	0	0	0	1	0	0	0	5571	1087	38	1	1231	1	FAM47C	23	37027712	Missense_Mutation	SNP	G	TCGA-74-6577-01A-11D-1845-08		37027712	118242848	46	18249											
DDX3X	1654	broad.mit.edu	37	chrX	41206682	41206683	+	In_Frame_Ins	INS	-	AGC	AGC													gtggcggaggtggccacggtINSagcagcagaggatttggtgg							TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chrX:41206682_41206683insAGC	uc004dfe.2	+	16	2742_2743	c.1887_1888insAGC	c.(1885-1890)insAGC	p.631_632insS	DDX3X_uc004dff.2_In_Frame_Ins_p.630_631insS|DDX3X_uc011mkq.1_In_Frame_Ins_p.615_616insS|DDX3X_uc011mkr.1_In_Frame_Ins_p.501_502insS|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	631_632	Gly/Ser-rich.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						gtggccacggtagcagcagAGG	0.228										HNSCC(61;0.18)			AGC	41206683	AGC	AGC	41206682	7	5	254	1	0	1	1	0	0	0	0	0	4358	1625	57	0	1949	0	DDX3X	23	41206682	In_Frame_Ins	INS	-	TCGA-74-6577-01A-11D-1845-08	4178970	41206682	114063878	47	18250											
STAG2	10735	broad.mit.edu	37	chrX	123197784	123197784	+	Nonsense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaagcatgttctaaaacttaCcatgcactctgtaatgaaga	7	8	2	2			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chrX:123197784C>G	uc004etz.3	+	19	2247	c.1908C>G	c.(1906-1908)TAC>TAG	p.Y636*	STAG2_uc004eua.2_Nonsense_Mutation_p.Y636*|STAG2_uc004eub.2_Nonsense_Mutation_p.Y636*|STAG2_uc004euc.2_Nonsense_Mutation_p.Y636*|STAG2_uc004eud.2_Nonsense_Mutation_p.Y636*|STAG2_uc004eue.2_Nonsense_Mutation_p.Y636*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	636					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CTAAAACTTACCATGCACTCT	0.363													G	123197784	G	G	123197784	4	3	254	1	0	0	0	0	0	1	0	0	15242	518	18	5	1978	5	STAG2	23	123197784	Nonsense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	81991102	123197784	32072776	48	18251											
FRMD7	90167	broad.mit.edu	37	chrX	131216403	131216403	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttaattacctatagcggaaaCtggaacccttgctgcagagt	9	9	0	1			TCGA-74-6577-01A-11D-1845-08	TCGA-74-6577-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	5be142d5-b6f7-4e1e-ae75-49b302b332a2	71a36569-7ec1-44fc-8a74-60291e49ec6b	g.chrX:131216403C>A	uc004ewn.2	-	9	1071	c.893G>T	c.(892-894)AGT>ATT	p.S298I	FRMD7_uc011muy.1_Missense_Mutation_p.S283I	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	298					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ATAGCGGAAACTGGAACCCTT	0.448													A	131216403	A	A	131216403	3	1	254	1	0	0	0	0	1	0	0	0	6055	565	20	5	1267	5	FRMD7	23	131216403	Missense_Mutation	SNP	C	TCGA-74-6577-01A-11D-1845-08	8018619	131216403	24054157	49	18252											
KIAA1751	85452	broad.mit.edu	37	chr1	1900265	1900265	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tctgagcttctgctcctcctCaaaggccctgcgtggagtcg	11	14	3	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:1900265C>G	uc001aim.1	-	11	1210	c.1054G>C	c.(1054-1056)GAG>CAG	p.E352Q	KIAA1751_uc009vkz.1_Missense_Mutation_p.E352Q	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	352	Potential.									pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TGCTCCTCCTCAAAGGCCCTG	0.597													G	1900265	G	G	1900265	3	3	255	1	0	0	0	0	1	0	0	0	8256	835	29	5	1266	5	KIAA1751	1	1900265	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08		1900265	247350356	1	18253											
MMEL1	79258	broad.mit.edu	37	chr1	2527458	2527458	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agccacataccttctcctgcGccttcttcttggactcctcg	6	17	3	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:2527458G>A	uc001ajy.2	-	15	1704	c.1490C>T	c.(1489-1491)GCG>GTG	p.A497V	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	497	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CTTCTCCTGCGCCTTCTTCTT	0.632													A	2527458	A	A	2527458	3	1	255	1	0	0	0	0	1	0	0	0	9646	1087	38	1	889	1	MMEL1	1	2527458	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	627193	2527458	246723163	2	18254											
KLHDC7A	127707	broad.mit.edu	37	chr1	18809060	18809060	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgcatgccccccgaggccGtgtcccggggctgtgccatc	13	18	0	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:18809060G>A	uc001bax.2	+	1	1637	c.1585G>A	c.(1585-1587)GTG>ATG	p.V529M	KLHDC7A_uc009vpg.2_Missense_Mutation_p.V311M	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	529	Kelch 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCGAGGCCGTGTCCCGGGG	0.662													A	18809060	A	A	18809060	3	1	255	1	0	0	0	0	1	0	0	0	8360	1145	40	1	1587	1	KLHDC7A	1	18809060	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	16281602	18809060	230441561	3	18255											
TXLNA	200081	broad.mit.edu	37	chr1	32650218	32650218	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaagaagtatgctgaactgGtcagttcccccctccgcggg	12	13	1	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:32650218G>A	uc001bui.2	+	4	662	c.597_splice	c.e4+1	p.L199_splice	TXLNA_uc001buj.2_Splice_Site_p.L199_splice	NM_175852	NP_787048	P40222	TXLNA_HUMAN	taxilin						cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TGCTGAACTGGTCAGTTCCCC	0.537													A	32650218	A	A	32650218	5	1	255	1	0	0	0	0	0	0	1	0	16784	1275	44	3	608	3	TXLNA	1	32650218	Splice_Site	SNP	G	TCGA-74-6578-01A-11D-1845-08	13841158	32650218	216600403	4	18256											
EPHA10	284656	broad.mit.edu	37	chr1	38227170	38227170	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcggcgccgcagtgcatgcGtggggggctgccaggctccc	18	14	0	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:38227170G>A	uc009vvi.2	-	3	843	c.757C>T	c.(757-759)CGC>TGC	p.R253C	EPHA10_uc001cbw.3_Missense_Mutation_p.R253C	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	253	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CAGTGCATGCGTGGGGGGCTG	0.692													A	38227170	A	A	38227170	3	1	255	1	0	0	0	0	1	0	0	0	5166	1145	40	1	2367	1	EPHA10	1	38227170	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	5576952	38227170	211023451	5	18257											
MACF1	23499	broad.mit.edu	37	chr1	39913453	39913453	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagttccttagccaaaagcaGgatgttgttctgatcaagaa	9	7	2	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:39913453G>A	uc010oiu.1	+	47	15311	c.15180G>A	c.(15178-15180)CAG>CAA	p.Q5060Q	MACF1_uc010ois.1_Silent_p.Q4558Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCCAAAAGCAGGATGTTGTTC	0.438													A	39913453	A	A	39913453	2	1	255	1	0	0	0	0	0	0	0	1	9144	991	35	3		3	MACF1	1	39913453	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08	1686283	39913453	209337168	6	18258											
SPAG17	200162	broad.mit.edu	37	chr1	118548128	118548128	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagctcgcagctgctcacgcTtttgaaaaggatagtatata	9	9	1	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:118548128T>C	uc001ehk.2	-	32	4753	c.4685A>G	c.(4684-4686)AAG>AGG	p.K1562R		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1562						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTGCTCACGCTTTTGAAAAGG	0.448													C	118548128	C	C	118548128	3	2	255	1	0	0	0	0	1	0	0	0	14979	1609	56	4	2054	4	SPAG17	1	118548128	Missense_Mutation	SNP	T	TCGA-74-6578-01A-11D-1845-08	78634675	118548128	130702493	7	18259											
HAO2	51179	broad.mit.edu	37	chr1	119925581	119925581	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tgagagatgtgtctgaggtgGacaccagaaccacaatccaa	11	9	1	4			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:119925581G>T	uc001ehq.1	+	4	527	c.175G>T	c.(175-177)GAC>TAC	p.D59Y	HAO2_uc001ehr.1_Missense_Mutation_p.D59Y	NM_001005783	NP_001005783	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2	59	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			ovary(2)|skin(2)	4	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		GTCTGAGGTGGACACCAGAAC	0.552													T	119925581	T	T	119925581	3	4	255	1	0	0	0	0	1	0	0	0	6952	1174	41	5	181	5	HAO2	1	119925581	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	1377453	119925581	129325040	8	18260											
ZNF697	90874	broad.mit.edu	37	chr1	120165681	120165681	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgctcacccgagtgcgtgcGcttgtgcgtgaagaggtgcg	16	12	1	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:120165681G>A	uc001ehy.1	-	3	1399	c.1285C>T	c.(1285-1287)CGC>TGC	p.R429C		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	429	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		GAGTGCGTGCGCTTGTGCGTG	0.667													A	120165681	A	A	120165681	3	1	255	1	0	0	0	0	1	0	0	0	18097	1087	38	1	356	1	ZNF697	1	120165681	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	240100	120165681	129084940	9	18261											
NOTCH2	4853	broad.mit.edu	37	chr1	120512133	120512133	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atccgtccttctgctacctaCctgccttcccctctgggcac	6	19	2	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:120512133C>T	uc001eik.2	-	6	1364	c.1108_splice	c.e6+1	p.G370_splice	NOTCH2_uc001eil.2_Splice_Site_p.G370_splice|NOTCH2_uc001eim.3_Splice_Site_p.G287_splice	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein						anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGCTACCTACCTGCCTTCCC	0.537			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				T	120512133	T	T	120512133	5	4	255	1	0	0	0	0	0	0	1	0	10548	521	18	3	6422	3	NOTCH2	1	120512133	Splice_Site	SNP	C	TCGA-74-6578-01A-11D-1845-08	346452	120512133	128738488	10	18262											
BCL9	607	broad.mit.edu	37	chr1	147091673	147091673	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	atttgcaggcatgataaactCtgaaatggaagggccgaatg	12	6	1	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:147091673C>G	uc001epq.2	+	8	2452	c.1712C>G	c.(1711-1713)TCT>TGT	p.S571C	BCL9_uc010ozr.1_Missense_Mutation_p.S497C	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	571	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					ATGATAAACTCTGAAATGGAA	0.547			T	IGH@|IGL@	B-ALL								G	147091673	G	G	147091673	3	3	255	1	0	0	0	0	1	0	0	0	1381	913	32	5	1730	5	BCL9	1	147091673	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	26579540	147091673	102158948	11	18263											
HRNR	388697	broad.mit.edu	37	chr1	152193180	152193180	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accggacccatgtcggacgtGgctaggagactggcgagatc	15	11	0	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:152193180G>A	uc001ezt.1	-	3	1001	c.925C>T	c.(925-927)CAC>TAC	p.H309Y		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	309	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCGGACGTGGCTAGGAGAC	0.602													A	152193180	A	A	152193180	3	1	255	1	0	0	0	0	1	0	0	0	7359	1348	47	3	7631	3	HRNR	1	152193180	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	5101507	152193180	97057441	12	18264											
ZBTB7B	51043	broad.mit.edu	37	chr1	154987218	154987218	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagctgcctcaatgagcagCgccagctgggccacctatgt	12	13	1	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:154987218C>T	uc001fgk.3	+	3	240	c.82C>T	c.(82-84)CGC>TGC	p.R28C	ZBTB7B_uc009wpa.2_Missense_Mutation_p.R28C|ZBTB7B_uc001fgj.3_Missense_Mutation_p.R62C|ZBTB7B_uc010peq.1_Missense_Mutation_p.R62C|ZBTB7B_uc001fgl.3_Missense_Mutation_p.R28C	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	28					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CAATGAGCAGCGCCAGCTGGG	0.592													T	154987218	T	T	154987218	3	4	255	1	0	0	0	0	1	0	0	0	17551	768	27	1	84	1	ZBTB7B	1	154987218	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	2794038	154987218	94263403	13	18265											
FAM78B	149297	broad.mit.edu	37	chr1	166039701	166039701	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctcatcctccacttgatgGtctgcagaatgatcttctcc	6	15	4	3			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:166039701G>A	uc001gdr.2	-	3	1153	c.563C>T	c.(562-564)ACC>ATC	p.T188I	FAM78B_uc010plc.1_RNA|FAM78B_uc001gdq.2_5'Flank	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	188										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					CCACTTGATGGTCTGCAGAAT	0.572													A	166039701	A	A	166039701	3	1	255	1	0	0	0	0	1	0	0	0	5627	1261	44	3	226	3	FAM78B	1	166039701	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	11052483	166039701	83210920	14	18266											
URB2	9816	broad.mit.edu	37	chr1	229772130	229772130	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctggcccttctcccggacacCccaggcccagagccagagct	10	19	1	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr1:229772130C>A	uc001hts.1	+	4	1906	c.1770C>A	c.(1768-1770)ACC>ACA	p.T590T	URB2_uc009xfd.1_Silent_p.T590T	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	590						nucleolus				central_nervous_system(2)|ovary(1)	3						TCCCGGACACCCCAGGCCCAG	0.597													A	229772130	A	A	229772130	2	1	255	1	0	0	0	0	0	0	0	1	17022	610	22	5		5	URB2	1	229772130	Silent	SNP	C	TCGA-74-6578-01A-11D-1845-08	63732429	229772130	19478491	15	18267											
PNPT1	87178	broad.mit.edu	37	chr2	55874482	55874482	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaaaccgagaatatacttgcCaaaatatctgtcagcaaacg	7	9	2	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr2:55874482C>G	uc002rzf.2	-	19	1655	c.1602G>C	c.(1600-1602)TTG>TTC	p.L534F	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	534					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ATATACTTGCCAAAATATCTG	0.284													G	55874482	G	G	55874482	3	3	255	1	0	0	0	0	1	0	0	0	12173	608	21	5	789	5	PNPT1	2	55874482	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08		55874482	187324891	16	18268											
SLC5A7	60482	broad.mit.edu	37	chr2	108625088	108625088	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagattcttccatcttgtcaGcaagttccatgtttgcacgg	8	11	3	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr2:108625088G>A	uc002tdv.2	+	8	1339	c.1063G>A	c.(1063-1065)GCA>ACA	p.A355T	SLC5A7_uc010ywm.1_Missense_Mutation_p.A108T|SLC5A7_uc010fjj.2_Missense_Mutation_p.A355T|SLC5A7_uc010ywn.1_Missense_Mutation_p.A242T	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	355	Extracellular (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CATCTTGTCAGCAAGTTCCAT	0.413													A	108625088	A	A	108625088	3	1	255	1	0	0	0	0	1	0	0	0	14670	971	34	3	1089	3	SLC5A7	2	108625088	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	52750606	108625088	134574285	17	18269											
CKAP2L	150468	broad.mit.edu	37	chr2	113504041	113504041	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ttcatatagcccaataacatCaaaggtgcctttacttgcca	5	11	2	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr2:113504041C>A	uc002tie.2	-	6	1793	c.1714G>T	c.(1714-1716)GAT>TAT	p.D572Y	CKAP2L_uc002tif.2_Missense_Mutation_p.D161Y|CKAP2L_uc010yxp.1_Missense_Mutation_p.D407Y	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	572						centrosome					0						CCAATAACATCAAAGGTGCCT	0.373													A	113504041	A	A	113504041	3	1	255	1	0	0	0	0	1	0	0	0	3443	826	29	5	539	5	CKAP2L	2	113504041	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	4878953	113504041	129695332	18	18270											
ABCB11	8647	broad.mit.edu	37	chr2	169791877	169791877	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcaagtgcttcaatgaacCgcctctcctttccaattcca	4	15	3	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr2:169791877C>T	uc002ueo.1	-	23	2999	c.2873G>A	c.(2872-2874)CGG>CAG	p.R958Q	ABCB11_uc010zda.1_Missense_Mutation_p.R400Q|ABCB11_uc010zdb.1_Missense_Mutation_p.R434Q	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	958	Cytoplasmic (Potential).|ABC transmembrane type-1 2.		R -> Q.		bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	TTCAATGAACCGCCTCTCCTT	0.448													T	169791877	T	T	169791877	3	4	255	1	0	0	0	0	1	0	0	0	42	652	23	2	1116	2	ABCB11	2	169791877	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	56287836	169791877	73407496	19	18271											
FZD5	7855	broad.mit.edu	37	chr2	208632195	208632195	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cggatgcggaagagcgacacGaagcccgccagcaggaagag	16	11	0	2	rs35642228		TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr2:208632195G>A	uc002vcj.2	-	2	1679	c.1269C>T	c.(1267-1269)TTC>TTT	p.F423F		NM_003468	NP_003459	Q13467	FZD5_HUMAN	frizzled 5 precursor	423	Helical; Name=5; (Potential).				angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			ovary(2)|lung(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		AGAGCGACACGAAGCCCGCCA	0.637													A	208632195	A	A	208632195	2	1	255	1	0	0	0	0	0	0	0	1	6133	1049	37	2		2	FZD5	2	208632195	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08	38840318	208632195	34567178	20	18272											
RBM44	375316	broad.mit.edu	37	chr2	238727201	238727201	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatcaggaaaatctctctccGttgacagtttaaaacctaat	6	9	3	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr2:238727201G>A	uc002vxi.3	+	3	1774	c.1642G>A	c.(1642-1644)GTT>ATT	p.V548I		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	547							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		ATCTCTCTCCGTTGACAGTTT	0.308													A	238727201	A	A	238727201	3	1	255	1	0	0	0	0	1	0	0	0	13138	1145	40	1	1648	1	RBM44	2	238727201	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	30095006	238727201	4472172	21	18273											
DLEC1	9940	broad.mit.edu	37	chr3	38153750	38153750	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaggagctgctttcttcccTcacttttcccagggcatgct	8	13	2	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr3:38153750T>C	uc003cho.1	+	25	3585	c.3564T>C	c.(3562-3564)CCT>CCC	p.P1188P	DLEC1_uc003chp.1_Silent_p.P1188P|DLEC1_uc010hgv.1_Silent_p.P1191P|DLEC1_uc003chr.1_Intron|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	1188					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CTTTCTTCCCTCACTTTTCCC	0.572													C	38153750	C	C	38153750	2	2	255	1	0	0	0	0	0	0	0	1	4552	1538	54	4		4	DLEC1	3	38153750	Silent	SNP	T	TCGA-74-6578-01A-11D-1845-08		38153750	159868680	22	18274											
SCN5A	6331	broad.mit.edu	37	chr3	38591818	38591818	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agccaggccgaggctcacacGatggactcacggtccctgtc	12	15	2	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr3:38591818G>A	uc003cio.2	-	28	6239	c.6045C>T	c.(6043-6045)ATC>ATT	p.I2015I	SCN5A_uc003cin.2_Silent_p.I2014I|SCN5A_uc003cil.3_Silent_p.I2015I|SCN5A_uc010hhi.2_Silent_p.I1997I|SCN5A_uc010hhk.2_Silent_p.I1982I|SCN5A_uc011ayr.1_Silent_p.I1961I	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	2015					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGGCTCACACGATGGACTCAC	0.592													A	38591818	A	A	38591818	2	1	255	1	0	0	0	0	0	0	0	1	13922	1048	37	2		2	SCN5A	3	38591818	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08	438068	38591818	159430612	23	18275											
PBRM1	55193	broad.mit.edu	37	chr3	52598198	52598198	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaatgtcattttctggtattTcagttggcctgcaggagagg	13	6	3	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr3:52598198T>C	uc003des.2	-	23	3755	c.3743A>G	c.(3742-3744)GAA>GGA	p.E1248G	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E1248G|PBRM1_uc003der.2_Missense_Mutation_p.E1216G|PBRM1_uc003det.2_Missense_Mutation_p.E1263G|PBRM1_uc003deu.2_Missense_Mutation_p.E1263G|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E1248G|PBRM1_uc010hmk.1_Missense_Mutation_p.E1223G|PBRM1_uc003dey.2_Missense_Mutation_p.E1223G|PBRM1_uc003dez.1_Missense_Mutation_p.E1247G	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1248	BAH 2.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TTCTGGTATTTCAGTTGGCCT	0.408			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								C	52598198	C	C	52598198	3	2	255	1	0	0	0	0	1	0	0	0	11491	1783	62	4	1189	4	PBRM1	3	52598198	Missense_Mutation	SNP	T	TCGA-74-6578-01A-11D-1845-08	14006380	52598198	145424232	24	18276											
UBA3	9039	broad.mit.edu	37	chr3	69120763	69120763	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaatctgtctaaaaccagaCaaggcctgtgggaataaaaa	9	7	2	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr3:69120763C>T	uc003dno.2	-	5	290	c.270G>A	c.(268-270)TTG>TTA	p.L90L	UBA3_uc003dnq.2_Silent_p.L76L|UBA3_uc011bfy.1_5'UTR|UBA3_uc011bfz.1_Intron	NM_003968	NP_003959	Q8TBC4	UBA3_HUMAN	ubiquitin-activating enzyme 3 isoform 1	90					protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		TAAAACCAGACAAGGCCTGTG	0.313													T	69120763	T	T	69120763	2	4	255	1	0	0	0	0	0	0	0	1	16826	477	17	3		3	UBA3	3	69120763	Silent	SNP	C	TCGA-74-6578-01A-11D-1845-08	16522565	69120763	128901667	25	18277											
SENP7	57337	broad.mit.edu	37	chr3	101080632	101080632	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atataaaatccagttgtagaTccatctcattactaggcata	5	8	1	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr3:101080632T>G	uc003dut.2	-	11	1661	c.1550A>C	c.(1549-1551)GAT>GCT	p.D517A	SENP7_uc003duu.2_Missense_Mutation_p.D452A|SENP7_uc003duv.2_Missense_Mutation_p.D484A|SENP7_uc003duw.2_Missense_Mutation_p.D451A|SENP7_uc003dux.2_Missense_Mutation_p.D353A	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	517					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						CAGTTGTAGATCCATCTCATT	0.289													G	101080632	G	G	101080632	3	3	255	1	0	0	0	0	1	0	0	0	14051	1435	50	5	1658	5	SENP7	3	101080632	Missense_Mutation	SNP	T	TCGA-74-6578-01A-11D-1845-08	31959869	101080632	96941798	26	18278											
PIK3CA	5290	broad.mit.edu	37	chr3	178936092	178936092	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctctctctgaaatcactgAgcaggagaaagattttctat	7	9	4	4	rs121913274		TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr3:178936092A>C	uc003fjk.2	+	10	1791	c.1634A>C	c.(1633-1635)GAG>GCG	p.E545A		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAATCACTGAGCAGGAGAAA	0.353	E545G(KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545A(AGS_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			C	178936092	C	C	178936092	3	2	255	1	0	0	0	0	1	0	0	0	11913	304	11	5	1668	5	PIK3CA	3	178936092	Missense_Mutation	SNP	A	TCGA-74-6578-01A-11D-1845-08	77855460	178936092	19086338	27	18279											
TTC14	151613	broad.mit.edu	37	chr3	180321035	180321035	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggaagaattagttctattcGggaattcggttttttcatgg	11	4	2	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr3:180321035G>A	uc003fkk.2	+	3	542	c.410G>A	c.(409-411)CGG>CAG	p.R137Q	TTC14_uc003fkl.2_Missense_Mutation_p.R137Q|TTC14_uc003fkm.2_Missense_Mutation_p.R137Q	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	137	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AGTTCTATTCGGGAATTCGGT	0.373													A	180321035	A	A	180321035	3	1	255	1	0	0	0	0	1	0	0	0	16678	1116	39	2	420	2	TTC14	3	180321035	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	1384943	180321035	17701395	28	18280											
ACAP2	23527	broad.mit.edu	37	chr3	195015481	195015481	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actattggctgacaccgtggAgggtaaagattctcttccat	10	9	1	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr3:195015481A>G	uc003fun.3	-	18	1973	c.1732T>C	c.(1732-1734)TCC>CCC	p.S578P		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	578					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GACACCGTGGAGGGTAAAGAT	0.368													G	195015481	G	G	195015481	3	3	255	1	0	0	0	0	1	0	0	0	119	304	11	4	628	4	ACAP2	3	195015481	Missense_Mutation	SNP	A	TCGA-74-6578-01A-11D-1845-08	14694446	195015481	3006949	29	18281											
TLR6	10333	broad.mit.edu	37	chr4	38830189	38830189	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	attgtcaatgctttcaatgtCgttttagaataagtaaaatc	6	5	2	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr4:38830189C>T	uc003gtm.2	-	1	972	c.906G>A	c.(904-906)ACG>ACA	p.T302T	TLR6_uc010ifg.1_Silent_p.T302T	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	302	Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						CTTTCAATGTCGTTTTAGAAT	0.318													T	38830189	T	T	38830189	2	4	255	1	0	0	0	0	0	0	0	1	15952	871	31	2		2	TLR6	4	38830189	Silent	SNP	C	TCGA-74-6578-01A-11D-1845-08		38830189	152324087	30	18282											
CENPC1	1060	broad.mit.edu	37	chr4	68396616	68396616	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagaaactggaactgactttGgatgtgatttctggcactga	11	6	1	4			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr4:68396616G>A	uc003hdd.1	-	5	431	c.248C>T	c.(247-249)CCA>CTA	p.P83L	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihm.1_Missense_Mutation_p.P83L	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	83					mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2						AACTGACTTTGGATGTGATTT	0.363													A	68396616	A	A	68396616	3	1	255	1	0	0	0	0	1	0	0	0	3229	1348	47	3	2643	3	CENPC1	4	68396616	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	29566427	68396616	122757660	31	18283											
UGT2B7	7364	broad.mit.edu	37	chr4	69978432	69978432	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctggaagtttgctagaaaagCaaagaagggaaaaaatgatt	11	3	0	3			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr4:69978432C>G	uc003heg.3	+	6	1614	c.1568C>G	c.(1567-1569)GCA>GGA	p.A523G	UGT2B7_uc010ihq.2_3'UTR	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	523					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GCTAGAAAAGCAAAGAAGGGA	0.378													G	69978432	G	G	69978432	3	3	255	1	0	0	0	0	1	0	0	0	16959	710	25	5	1590	5	UGT2B7	4	69978432	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	1581816	69978432	121175844	32	18284											
SHROOM3	57619	broad.mit.edu	37	chr4	77660381	77660381	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaatggtctaatattcctcGgggcaagggagtgccacccc	11	11	1	0	rs146652221	byFrequency	TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr4:77660381G>A	uc011cbx.1	+	5	2008	c.1055G>A	c.(1054-1056)CGG>CAG	p.R352Q	SHROOM3_uc011cbz.1_Missense_Mutation_p.R176Q|SHROOM3_uc003hkf.1_Missense_Mutation_p.R227Q|SHROOM3_uc003hkg.2_Missense_Mutation_p.R130Q	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	352					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			AATATTCCTCGGGGCAAGGGA	0.582													A	77660381	A	A	77660381	3	1	255	1	0	0	0	0	1	0	0	0	14295	1116	39	2	1073	2	SHROOM3	4	77660381	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	7681949	77660381	113493895	33	18285											
FRAS1	80144	broad.mit.edu	37	chr4	79351554	79351554	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	taagcatacagctgagttccGaaggccgatggccacaggta	12	10	0	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr4:79351554G>A	uc003hlb.2	+	37	5392	c.4952G>A	c.(4951-4953)CGA>CAA	p.R1651Q	FRAS1_uc003hkw.2_Missense_Mutation_p.R1651Q|FRAS1_uc010ijj.1_Missense_Mutation_p.R71Q	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1650	CSPG 5.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GCTGAGTTCCGAAGGCCGATG	0.493													A	79351554	A	A	79351554	3	1	255	1	0	0	0	0	1	0	0	0	6042	1058	37	2	5098	2	FRAS1	4	79351554	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	1691173	79351554	111802722	34	18286											
ANK2	287	broad.mit.edu	37	chr4	114262932	114262932	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttatctgcgtaccttatatgGccaaatttgtagtgtttgcc	8	8	1	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr4:114262932G>A	uc003ibe.3	+	33	4082	c.3982G>A	c.(3982-3984)GCC>ACC	p.A1328T	ANK2_uc003ibd.3_Missense_Mutation_p.A1319T|ANK2_uc003ibf.3_Missense_Mutation_p.A1328T|ANK2_uc011cgc.1_Missense_Mutation_p.A504T|ANK2_uc003ibg.3_Missense_Mutation_p.A323T|ANK2_uc003ibh.3_Missense_Mutation_p.A2T|ANK2_uc011cgb.1_Missense_Mutation_p.A1343T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1295					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACCTTATATGGCCAAATTTGT	0.393													A	114262932	A	A	114262932	3	1	255	1	0	0	0	0	1	0	0	0	621	1203	42	3	4177	3	ANK2	4	114262932	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	34911378	114262932	76891344	35	18287											
RGNEF	64283	broad.mit.edu	37	chr5	73128174	73128174	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtactctagatcgctccttcGatatcctaaaaaaatccaag	5	11	1	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr5:73128174G>A	uc011csq.1	+	9	1047	c.1036G>A	c.(1036-1038)GAT>AAT	p.D346N	RGNEF_uc003kcx.2_Missense_Mutation_p.D346N|RGNEF_uc003kcy.1_Missense_Mutation_p.D346N|RGNEF_uc010izf.2_Missense_Mutation_p.D346N|RGNEF_uc011csr.1_Missense_Mutation_p.D33N	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	346					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		TCGCTCCTTCGATATCCTAAA	0.423													A	73128174	A	A	73128174	3	1	255	1	0	0	0	0	1	0	0	0	13283	1058	37	2	1070	2	RGNEF	5	73128174	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08		73128174	107787086	36	18288											
SLC36A2	153201	broad.mit.edu	37	chr5	150726999	150726999	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caacggctccctggggacccTcagtactttttgtcacagac	9	14	2	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr5:150726999T>A	uc003lty.2	-	1	153	c.23A>T	c.(22-24)GAG>GTG	p.E8V	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_5'UTR|SLC36A2_uc010jhv.2_Missense_Mutation_p.E8V|SLC36A2_uc011dct.1_Missense_Mutation_p.E8V	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	8	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGGGGACCCTCAGTACTTTT	0.493													A	150726999	A	A	150726999	3	1	255	1	0	0	0	0	1	0	0	0	14594	1551	54	5	1468	5	SLC36A2	5	150726999	Missense_Mutation	SNP	T	TCGA-74-6578-01A-11D-1845-08	77598825	150726999	30188261	37	18289											
DSP	1832	broad.mit.edu	37	chr6	7575560	7575560	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacttgaacttgaagaagtcGttgttggccactatgaagac	11	7	0	5			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr6:7575560G>A	uc003mxp.1	+	18	2748	c.2469G>A	c.(2467-2469)TCG>TCA	p.S823S	DSP_uc003mxq.1_Silent_p.S823S	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	823	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGAAGAAGTCGTTGTTGGCCA	0.393													A	7575560	A	A	7575560	2	1	255	1	0	0	0	0	0	0	0	1	4781	1132	40	1		1	DSP	6	7575560	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08		7575560	163539507	38	18290											
RHAG	6005	broad.mit.edu	37	chr6	49582542	49582542	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tggccgagttaaagctgggcCaaaacatccacagaaagaga	11	9	0	2	rs77467572		TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr6:49582542C>A	uc003ozk.3	-	5	727	c.665G>T	c.(664-666)TGG>TTG	p.W222L	RHAG_uc010jzl.2_Missense_Mutation_p.W222L|RHAG_uc010jzm.2_Missense_Mutation_p.W222L	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	222	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					AAAGCTGGGCCAAAACATCCA	0.463													A	49582542	A	A	49582542	3	1	255	1	0	0	0	0	1	0	0	0	13315	595	21	5	588	5	RHAG	6	49582542	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	42006982	49582542	121532525	39	18291											
COL9A1	1297	broad.mit.edu	37	chr6	70961988	70961988	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tttgcctgaatttcccatctGaccaggcttccctggagcac	8	14	1	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr6:70961988G>A	uc003pfg.3	-	27	1954	c.1795C>T	c.(1795-1797)CAG>TAG	p.Q599*	COL9A1_uc003pfe.3_Nonsense_Mutation_p.Q172*|COL9A1_uc003pff.3_Nonsense_Mutation_p.Q356*	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	599	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						TTTCCCATCTGACCAGGCTTC	0.423													A	70961988	A	A	70961988	4	1	255	1	0	0	0	0	0	1	0	0	3707	1299	45	3	1018	3	COL9A1	6	70961988	Nonsense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	21379446	70961988	100153079	40	18292											
COL1A2	1278	broad.mit.edu	37	chr7	94039079	94039079	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccggcctccctggaccccgCggtattcctggccctgttgg	12	18	0	0	rs141762645	byFrequency	TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr7:94039079C>T	uc003ung.1	+	19	1452	c.981C>T	c.(979-981)CGC>CGT	p.R327R	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	327					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTGGACCCCGCGGTATTCCTG	0.592										HNSCC(75;0.22)			T	94039079	T	T	94039079	2	4	255	1	0	0	0	0	0	0	0	1	3678	755	27	1		1	COL1A2	7	94039079	Silent	SNP	C	TCGA-74-6578-01A-11D-1845-08		94039079	65099584	41	18293											
CNTNAP2	26047	broad.mit.edu	37	chr7	146536869	146536869	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaggttgactttggcaatcGgaagcagatcagtgccattg	12	8	2	2	rs138924087		TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr7:146536869G>A	uc003weu.1	+	3	791	c.275G>A	c.(274-276)CGG>CAG	p.R92Q		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	92	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTTGGCAATCGGAAGCAGATC	0.502										HNSCC(39;0.1)			A	146536869	A	A	146536869	3	1	255	1	0	0	0	0	1	0	0	0	3647	1116	39	2	285	2	CNTNAP2	7	146536869	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	52497790	146536869	12601794	42	18294											
DOCK5	80005	broad.mit.edu	37	chr8	25220568	25220568	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctctgttctccgcaggacttCctcatggaaacttttatcat	6	12	4	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr8:25220568C>A	uc003xeg.2	+	29	3092	c.2955C>A	c.(2953-2955)TTC>TTA	p.F985L	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.F699L|DOCK5_uc003xei.2_Missense_Mutation_p.F555L|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	985						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CGCAGGACTTCCTCATGGAAA	0.443													A	25220568	A	A	25220568	3	1	255	1	0	0	0	0	1	0	0	0	4690	854	30	5	3069	5	DOCK5	8	25220568	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08		25220568	121143454	43	18295											
FNTA	2339	broad.mit.edu	37	chr8	42939877	42939877	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgcaggatcgtggtctttcCaaatatcctaatctgttaaa	7	8	2	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr8:42939877C>T	uc003xps.2	+	8	918	c.870C>T	c.(868-870)TCC>TCT	p.S290S	FNTA_uc003xpt.2_Silent_p.S199S|FNTA_uc003xpu.2_Silent_p.S223S|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	290					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			GTGGTCTTTCCAAATATCCTA	0.343													T	42939877	T	T	42939877	2	4	255	1	0	0	0	0	0	0	0	1	5977	581	21	3		3	FNTA	8	42939877	Silent	SNP	C	TCGA-74-6578-01A-11D-1845-08	17719309	42939877	103424145	44	18296											
SPAG1	6674	broad.mit.edu	37	chr8	101203698	101203698	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttgagtaaagtactagatGttgagcctgataatgatttg	10	3	0	5			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr8:101203698G>A	uc003yjh.1	+	9	999	c.913G>A	c.(913-915)GTT>ATT	p.V305I	SPAG1_uc003yjg.1_Missense_Mutation_p.V305I|SPAG1_uc003yji.1_Missense_Mutation_p.V305I	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	305	TPR 3.				single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		AGTACTAGATGTTGAGCCTGA	0.348													A	101203698	A	A	101203698	3	1	255	1	0	0	0	0	1	0	0	0	14975	1377	48	3	943	3	SPAG1	8	101203698	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	58263821	101203698	45160324	45	18297											
FER1L6	654463	broad.mit.edu	37	chr8	125131869	125131869	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcccagacacctccttttcGtggttcatgagcccctttaa	7	15	1	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr8:125131869G>A	uc003yqw.2	+	41	5618	c.5412G>A	c.(5410-5412)TCG>TCA	p.S1804S	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1804	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCTCCTTTTCGTGGTTCATGA	0.378													A	125131869	A	A	125131869	2	1	255	1	0	0	0	0	0	0	0	1	5815	1132	40	1		1	FER1L6	8	125131869	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08	23928171	125131869	21232153	46	18298											
PLEC	5339	broad.mit.edu	37	chr8	144992335	144992335	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctgcttccgcaggccacggAaggtcagcttgcgggcgtcc	14	14	2	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr8:144992335A>G	uc003zaf.1	-	32	12235	c.12065T>C	c.(12064-12066)TTC>TCC	p.F4022S	PLEC_uc003zab.1_Missense_Mutation_p.F3885S|PLEC_uc003zac.1_Missense_Mutation_p.F3889S|PLEC_uc003zad.2_Missense_Mutation_p.F3885S|PLEC_uc003zae.1_Missense_Mutation_p.F3853S|PLEC_uc003zag.1_Missense_Mutation_p.F3863S|PLEC_uc003zah.2_Missense_Mutation_p.F3871S|PLEC_uc003zaj.2_Missense_Mutation_p.F3912S	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4022	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CAGGCCACGGAAGGTCAGCTT	0.692													G	144992335	G	G	144992335	3	3	255	1	0	0	0	0	1	0	0	0	12052	246	9	4	1993	4	PLEC	8	144992335	Missense_Mutation	SNP	A	TCGA-74-6578-01A-11D-1845-08	19860466	144992335	1371687	47	18299											
GLDC	2731	broad.mit.edu	37	chr9	6592871	6592871	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtgccatcctcaaaaagccGaaaattgatctgccgctgag	9	11	2	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr9:6592871G>A	uc003zkc.2	-	10	1574	c.1381C>T	c.(1381-1383)CGG>TGG	p.R461W		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	461					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TCAAAAAGCCGAAAATTGATC	0.403													A	6592871	A	A	6592871	3	1	255	1	0	0	0	0	1	0	0	0	6433	1057	37	2	1745	2	GLDC	9	6592871	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08		6592871	134620560	48	18300											
PAX5	5079	broad.mit.edu	37	chr9	37020754	37020754	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gactacatccgggagtggccGtccattcacaaaaacccccc	8	16	1	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr9:37020754G>A	uc003zzo.1	-	2	539	c.91C>T	c.(91-93)CGG>TGG	p.R31W	PAX5_uc011lpw.1_Missense_Mutation_p.R31W|PAX5_uc011lpx.1_Missense_Mutation_p.R31W|PAX5_uc011lpy.1_Intron|PAX5_uc010mls.1_Missense_Mutation_p.R31W|PAX5_uc011lpz.1_Missense_Mutation_p.R31W|PAX5_uc011lqa.1_Intron|PAX5_uc010mlq.1_RNA|PAX5_uc011lqb.1_RNA|PAX5_uc010mlo.1_Missense_Mutation_p.R31W|PAX5_uc010mlp.1_Missense_Mutation_p.R31W|PAX5_uc011lqc.1_Missense_Mutation_p.R31W|PAX5_uc010mlr.1_Missense_Mutation_p.R31W|PAX5_uc011lqd.1_Missense_Mutation_p.R30W|PAX5_uc011lqe.1_Intron|PAX5_uc011lqf.1_Intron|PAX5_uc011lqg.1_Intron	NM_016734	NP_057953	Q02548	PAX5_HUMAN	paired box 5	31	Paired.				cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(31)	PAX5/JAK2(18)	haematopoietic_and_lymphoid_tissue(142)|lung(3)|central_nervous_system(2)	147		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		GGGAGTGGCCGTCCATTCACA	0.522			T|Mis|D|F|S	IGH@|ETV6|PML|FOXP1|ZNF521|ELN	NHL|ALL|B-ALL								A	37020754	A	A	37020754	3	1	255	1	0	0	0	0	1	0	0	0	11482	1144	40	1	1120	1	PAX5	9	37020754	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	30427883	37020754	104192677	49	18301											
CYLC2	1539	broad.mit.edu	37	chr9	105767035	105767035	+	Frame_Shift_Del	DEL	C	-	-													accattatggatgtaccgttCtttaatgagaatttctgaga							TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr9:105767035delC	uc004bbs.2	+	4	309	c.239delC	c.(238-240)TCTfs	p.S80fs		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	80	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				ATGTACCGTTCTTTAATGAGA	0.398													-	105767035	-	-	105767035	7	5	255	1	0	1	0	1	0	0	0	0	4142	913	32	0	253	0	CYLC2	9	105767035	Frame_Shift_Del	DEL	C	TCGA-74-6578-01A-11D-1845-08	68746281	105767035	35446396	50	18302											
NOXA1	10811	broad.mit.edu	37	chr9	140327980	140327980	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacagtggccctgagggcaCgaagaggagccgacctgtcc	14	13	1	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr9:140327980C>T	uc004cmv.2	+	11	1120	c.985C>T	c.(985-987)CGA>TGA	p.R329*	C9orf167_uc011mew.1_Intron|NOXA1_uc004cmu.2_Nonsense_Mutation_p.R329*|NOXA1_uc010nch.2_Nonsense_Mutation_p.R273*	NM_006647	NP_006638	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	329	OPR.		Missing (in NOXA1truncated, a cDNA isolated from Caco-2 cells treated with butyrate).	R -> G (in Ref. 6; AAC18046).	regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity				0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)		CCTGAGGGCACGAAGAGGAGC	0.701													T	140327980	T	T	140327980	4	4	255	1	0	0	0	0	0	1	0	0	10560	528	19	1	1027	1	NOXA1	9	140327980	Nonsense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	34560945	140327980	885451	51	18303											
ZNF365	22891	broad.mit.edu	37	chr10	64415230	64415230	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggaaaacccaagtttggcGttggcagtcaggtaattcat	12	7	2	0	rs41306564		TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr10:64415230G>A	uc001jmd.1	+	4	564	c.230G>A	c.(229-231)CGT>CAT	p.R77H	ZNF365_uc001jmc.2_Intron|ZNF365_uc001jme.1_Intron|ZNF365_uc001jmf.1_Intron|ZNF365_uc009xpg.1_Intron	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	77										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					CAAGTTTGGCGTTGGCAGTCA	0.507													A	64415230	A	A	64415230	3	1	255	1	0	0	0	0	1	0	0	0	17866	1145	40	1	1718	1	ZNF365	10	64415230	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08		64415230	71119517	52	18304											
SMC3	9126	broad.mit.edu	37	chr10	112350849	112350851	+	In_Frame_Del	DEL	AAC	-	-													aggttacttttctgcctcttAacaagttagatgtcagggat							TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr10:112350849_112350851delAAC	uc001kze.2	+	17	1897_1899	c.1771_1773delAAC	c.(1771-1773)AACdel	p.N591del		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	591	Flexible hinge.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TCTGCCTCTTAACAAGTTAGATG	0.325													-	112350851	-	-	112350849	7	5	255	1	0	1	0	1	0	0	0	0	14784	362	13	0	1837	0	SMC3	10	112350849	In_Frame_Del	DEL	AAC	TCGA-74-6578-01A-11D-1845-08	47935619	112350849	23183898	53	18305											
HPX	3263	broad.mit.edu	37	chr11	6462111	6462111	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctagtcccagctttactcacGgaggaagaggggtggcaatg	14	9	1	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr11:6462111G>A	uc001mdg.2	-	1	144	c.83C>T	c.(82-84)CCG>CTG	p.P28L	HPX_uc009yfc.2_RNA|HPX_uc010rai.1_Missense_Mutation_p.P28L	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	28	O-glycosylated at one, two and three sites.				cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		CTTTACTCACGGAGGAAGAGG	0.572													A	6462111	A	A	6462111	3	1	255	1	0	0	0	0	1	0	0	0	7346	1130	39	2	1345	2	HPX	11	6462111	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08		6462111	128544405	54	18306											
DHCR7	1717	broad.mit.edu	37	chr11	71146770	71146770	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcccatccgtgcggcggaacAggtccttctggtggttggcc	15	13	1	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr11:71146770A>T	uc001oqk.2	-	9	1329	c.1079T>A	c.(1078-1080)CTG>CAG	p.L360Q	DHCR7_uc001oql.2_Missense_Mutation_p.L360Q	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	360					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)	GCGGCGGAACAGGTCCTTCTG	0.662									Smith-Lemli-Opitz_syndrome				T	71146770	T	T	71146770	3	4	255	1	0	0	0	0	1	0	0	0	4477	188	7	5	352	5	DHCR7	11	71146770	Missense_Mutation	SNP	A	TCGA-74-6578-01A-11D-1845-08	64684659	71146770	63859746	55	18307											
C11orf67	28971	broad.mit.edu	37	chr11	77580777	77580777	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccacatccagcattctcctGgtgtgcagcctgcagatgtg	10	13	1	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr11:77580777G>A	uc001oyq.2	+	3	240	c.142G>A	c.(142-144)GGT>AGT	p.G48S	C11orf67_uc001oyp.2_Missense_Mutation_p.G48S|C11orf67_uc001oyr.1_Missense_Mutation_p.G48S	NM_024684	NP_078960	Q9H7C9	CK067_HUMAN	hypothetical protein LOC28971	48											0	all_cancers(14;5.69e-19)|all_epithelial(13;2.15e-21)|Breast(9;1.16e-15)|Ovarian(111;0.152)		Epithelial(5;1.37e-49)|all cancers(3;5.58e-46)|BRCA - Breast invasive adenocarcinoma(5;7.26e-31)			GCATTCTCCTGGTGTGCAGCC	0.433													A	77580777	A	A	77580777	3	1	255	1	0	0	0	0	1	0	0	0	1657	1348	47	3	148	3	C11orf67	11	77580777	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	6434007	77580777	57425739	56	18308											
ASAM	79827	broad.mit.edu	37	chr11	122945484	122945484	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attagcagccacaccaagagGaaaatcagcagggctccagc	10	12	1	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr11:122945484G>A	uc001pyt.2	-	6	1106	c.747C>T	c.(745-747)TTC>TTT	p.F249F		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	249	Helical; (Potential).					integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		ACACCAAGAGGAAAATCAGCA	0.443													A	122945484	A	A	122945484	2	1	255	1	0	0	0	0	0	0	0	1	1009	1165	41	3		3	ASAM	11	122945484	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08	45364707	122945484	12061032	57	18309											
NCAPD3	23310	broad.mit.edu	37	chr11	134048751	134048751	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagacgaagccaggacggaCtgaatcagaaggaagatgcg	15	8	1	4			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr11:134048751C>T	uc001qhd.1	-	21	3246	c.2640G>A	c.(2638-2640)CAG>CAA	p.Q880Q	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	880					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CCAGGACGGACTGAATCAGAA	0.468													T	134048751	T	T	134048751	2	4	255	1	0	0	0	0	0	0	0	1	10206	564	20	3		3	NCAPD3	11	134048751	Silent	SNP	C	TCGA-74-6578-01A-11D-1845-08	11103267	134048751	957765	58	18310											
PLBD1	79887	broad.mit.edu	37	chr12	14695158	14695158	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtactccataaaatcctgcaCtttatccatgatggaaggtt	7	9	0	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr12:14695158C>T	uc001rcc.1	-	3	564	c.403G>A	c.(403-405)GTG>ATG	p.V135M		NM_024829	NP_079105	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	135					lipid catabolic process	extracellular region	hydrolase activity				0						AAATCCTGCACTTTATCCATG	0.343													T	14695158	T	T	14695158	3	4	255	1	0	0	0	0	1	0	0	0	12025	565	20	3	1294	3	PLBD1	12	14695158	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08		14695158	119156737	59	18311											
ABCC9	10060	broad.mit.edu	37	chr12	21997449	21997449	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	attagtatcagctgaaaagcGattgagaatcagtcccaggg	11	7	2	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr12:21997449G>A	uc001rfi.1	-	26	3303	c.3283C>T	c.(3283-3285)CGC>TGC	p.R1095C	ABCC9_uc001rfh.2_Missense_Mutation_p.R1095C|ABCC9_uc001rfj.1_Missense_Mutation_p.R1059C	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1095	ABC transmembrane type-1 2.|Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCTGAAAAGCGATTGAGAATC	0.353													A	21997449	A	A	21997449	3	1	255	1	0	0	0	0	1	0	0	0	59	1058	37	2	1560	2	ABCC9	12	21997449	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	7302291	21997449	111854446	60	18312											
PKP2	5318	broad.mit.edu	37	chr12	32977045	32977045	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accagtgagtcaatgagtccGtcacatcttctcatcgcttt	7	12	4	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr12:32977045G>A	uc001rlj.3	-	8	1855	c.1740C>T	c.(1738-1740)GAC>GAT	p.D580D	PKP2_uc001rlk.3_Silent_p.D536D|PKP2_uc010skj.1_Silent_p.D536D	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	580	ARM 4.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CAATGAGTCCGTCACATCTTC	0.398													A	32977045	A	A	32977045	2	1	255	1	0	0	0	0	0	0	0	1	11985	1136	40	1		1	PKP2	12	32977045	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08	10979596	32977045	100874850	61	18313											
GRIP1	23426	broad.mit.edu	37	chr12	66786464	66786464	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	attcactactcaccatctgtCtgtttcttaattttcaaggt	4	10	6	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr12:66786464C>G	uc001stk.2	-	17	2347	c.2106G>C	c.(2104-2106)CAG>CAC	p.Q702H	GRIP1_uc010sta.1_Missense_Mutation_p.Q646H|GRIP1_uc001stj.2_Missense_Mutation_p.Q484H|GRIP1_uc001stl.1_Missense_Mutation_p.Q594H|GRIP1_uc001stm.2_Missense_Mutation_p.Q702H	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	754	PDZ 6.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CACCATCTGTCTGTTTCTTAA	0.413													G	66786464	G	G	66786464	3	3	255	1	0	0	0	0	1	0	0	0	6787	912	32	5	1156	5	GRIP1	12	66786464	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	33809419	66786464	67065431	62	18314											
USP30	84749	broad.mit.edu	37	chr12	109509449	109509449	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttattccatgtcattacctcGtcattggaagatgagcgaga	9	8	2	3			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr12:109509449G>A	uc010sxi.1	+	5	617	c.513G>A	c.(511-513)TCG>TCA	p.S171S	USP30_uc001tnu.3_Silent_p.S140S	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	171	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						TCATTACCTCGTCATTGGAAG	0.463													A	109509449	A	A	109509449	2	1	255	1	0	0	0	0	0	0	0	1	17058	1132	40	1		1	USP30	12	109509449	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08	42722985	109509449	24342446	63	18315											
TMEM120B	144404	broad.mit.edu	37	chr12	122209423	122209423	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acccatttatcagaagtttcGcaaccagttcttagcatttt	5	10	2	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr12:122209423G>A	uc001ubc.3	+	8	791	c.647G>A	c.(646-648)CGC>CAC	p.R216H	TMEM120B_uc009zxh.2_Missense_Mutation_p.R216H	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	216						integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		CAGAAGTTTCGCAACCAGTTC	0.488													A	122209423	A	A	122209423	3	1	255	1	0	0	0	0	1	0	0	0	16031	1087	38	1	677	1	TMEM120B	12	122209423	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	12699974	122209423	11642472	64	18316											
LAMP1	3916	broad.mit.edu	37	chr13	113964010	113964010	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	agtggtgctcaaccgcagctCctgtggaaaagagaacactt	11	10	1	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr13:113964010C>A	uc001vtm.1	+	3	517	c.236C>A	c.(235-237)TCC>TAC	p.S79Y	LAMP1_uc010tka.1_Missense_Mutation_p.S79Y	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	79	Lumenal (Potential).|First lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			AACCGCAGCTCCTGTGGAAAA	0.443													A	113964010	A	A	113964010	3	1	255	1	0	0	0	0	1	0	0	0	8617	855	30	5	246	5	LAMP1	13	113964010	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08		113964010	1205868	65	18317											
OR4K1	79544	broad.mit.edu	37	chr14	20404274	20404274	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttgtgtctatttcctgggCggtgggcgttcttcattctg	12	8	4	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr14:20404274C>T	uc001vwj.1	+	1	449	c.449C>T	c.(448-450)GCG>GTG	p.A150V		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ATTTCCTGGGCGGTGGGCGTT	0.463													T	20404274	T	T	20404274	3	4	255	1	0	0	0	0	1	0	0	0	11067	768	27	1	451	1	OR4K1	14	20404274	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08		20404274	86945266	66	18318											
TGM5	9333	broad.mit.edu	37	chr15	43525396	43525396	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgttccagaatttataatGcaaagtctacataaacattc	5	7	1	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr15:43525396G>A	uc001zrd.1	-	13	2164	c.2156C>T	c.(2155-2157)GCA>GTA	p.A719V	TGM5_uc001zrc.1_Missense_Mutation_p.A376V|TGM5_uc001zre.1_Missense_Mutation_p.A637V	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	719					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	AATTTATAATGCAAAGTCTAC	0.438													A	43525396	A	A	43525396	3	1	255	1	0	0	0	0	1	0	0	0	15830	1319	46	3	10	3	TGM5	15	43525396	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08		43525396	59005996	67	18319											
BTBD1	53339	broad.mit.edu	37	chr15	83725179	83725179	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcattatctgccctaagatGtttggtgagaaattctacac	9	8	2	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr15:83725179G>A	uc002bjn.2	-	2	723	c.520C>T	c.(520-522)CAT>TAT	p.H174Y	BTBD1_uc002bjo.2_Missense_Mutation_p.H174Y	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	174						cytoplasmic mRNA processing body|protein complex	protein binding	p.H174D(1)		ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		GCCCTAAGATGTTTGGTGAGA	0.363													A	83725179	A	A	83725179	3	1	255	1	0	0	0	0	1	0	0	0	1537	1377	48	3	956	3	BTBD1	15	83725179	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	40199783	83725179	18806213	68	18320											
PKD1	5310	broad.mit.edu	37	chr16	2155892	2155892	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagcacggtgaccagggccaAcgagtactcgatgacgtgct	13	12	0	2	rs149467954	by1000genomes	TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr16:2155892A>G	uc002cos.1	-	20	8046	c.7837T>C	c.(7837-7839)TTG>CTG	p.L2613L	PKD1_uc002cot.1_Silent_p.L2613L|PKD1_uc010bse.1_5'Flank	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2613	Extracellular (Potential).|REJ.		Missing (in ADPKD1; could be a polymorphism).		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						ACCAGGGCCAACGAGTACTCG	0.657													G	2155892	G	G	2155892	2	3	255	1	0	0	0	0	0	0	0	1	11963	40	2	4		4	PKD1	16	2155892	Silent	SNP	A	TCGA-74-6578-01A-11D-1845-08		2155892	88198861	69	18321											
DNAH3	55567	broad.mit.edu	37	chr16	20999316	20999316	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtgccagtcaacaatcgaacTgaaaatcttggttaaaatgt	8	7	2	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr16:20999316T>A	uc010vbe.1	-	45	6673	c.6673A>T	c.(6673-6675)AGT>TGT	p.S2225C	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2225	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ACAATCGAACTGAAAATCTTG	0.428													A	20999316	A	A	20999316	3	1	255	1	0	0	0	0	1	0	0	0	4603	1580	55	5	5748	5	DNAH3	16	20999316	Missense_Mutation	SNP	T	TCGA-74-6578-01A-11D-1845-08	18843424	20999316	69355437	70	18322											
KCTD19	146212	broad.mit.edu	37	chr16	67327795	67327795	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtggcgggagggtctttggTttcagatttctgtgtgaggt	17	4	3	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr16:67327795T>C	uc002esu.2	-	12	1921	c.1870A>G	c.(1870-1872)ACC>GCC	p.T624A	KCTD19_uc002est.2_Missense_Mutation_p.T396A|KCTD19_uc010vjj.1_Missense_Mutation_p.T367A	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	624						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GGGTCTTTGGTTTCAGATTTC	0.532													C	67327795	C	C	67327795	3	2	255	1	0	0	0	0	1	0	0	0	8106	1725	60	4	930	4	KCTD19	16	67327795	Missense_Mutation	SNP	T	TCGA-74-6578-01A-11D-1845-08	46328479	67327795	23026958	71	18323											
SGSM2	9905	broad.mit.edu	37	chr17	2276367	2276367	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcggcatgagcaagaaggagAtggagcaggtgaggggagcc	19	6	0	4			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr17:2276367A>G	uc002fun.3	+	15	1949	c.1774A>G	c.(1774-1776)ATG>GTG	p.M592V	SGSM2_uc002fum.3_Missense_Mutation_p.M637V|SGSM2_uc010vqw.1_Missense_Mutation_p.M592V|SGSM2_uc002fuo.2_3'UTR|SGSM2_uc002fup.1_5'Flank	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	592	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		CAAGAAGGAGATGGAGCAGGT	0.617													G	2276367	G	G	2276367	3	3	255	1	0	0	0	0	1	0	0	0	14223	333	12	4	1971	4	SGSM2	17	2276367	Missense_Mutation	SNP	A	TCGA-74-6578-01A-11D-1845-08		2276367	78918843	72	18324											
UNC45B	146862	broad.mit.edu	37	chr17	33491149	33491149	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgcgctgtgacccggagcGcgatcacttccgcaagatct	11	15	2	2	rs143612410		TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr17:33491149G>A	uc002hja.2	+	9	1212	c.1115G>A	c.(1114-1116)CGC>CAC	p.R372H	UNC45B_uc002hjb.2_Missense_Mutation_p.R372H|UNC45B_uc002hjc.2_Missense_Mutation_p.R372H|UNC45B_uc010cto.2_Missense_Mutation_p.R372H	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	372					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				GACCCGGAGCGCGATCACTTC	0.478													A	33491149	A	A	33491149	3	1	255	1	0	0	0	0	1	0	0	0	16986	1087	38	1	1145	1	UNC45B	17	33491149	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	31214782	33491149	47704061	73	18325											
KIF2B	84643	broad.mit.edu	37	chr17	51900723	51900723	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcggccatcagggaccagcGtaccgccacgaaatgggttg	13	12	1	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr17:51900723G>A	uc002iua.2	+	1	485	c.329G>A	c.(328-330)CGT>CAT	p.R110H	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	110					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity	p.R110C(1)		ovary(5)|skin(3)	8						AGGGACCAGCGTACCGCCACG	0.607													A	51900723	A	A	51900723	3	1	255	1	0	0	0	0	1	0	0	0	8298	1145	40	1	331	1	KIF2B	17	51900723	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	18409574	51900723	29294487	74	18326											
ENPP7	339221	broad.mit.edu	37	chr17	77708908	77708908	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accaaggggtggctgtgacgCggagccggaaagaaggcatc	17	9	0	2	rs142610423		TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr17:77708908C>T	uc002jxa.2	+	3	486	c.466C>T	c.(466-468)CGG>TGG	p.R156W		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	156					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGCTGTGACGCGGAGCCGGAA	0.592													T	77708908	T	T	77708908	3	4	255	1	0	0	0	0	1	0	0	0	5135	759	27	1	476	1	ENPP7	17	77708908	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	25808185	77708908	3486302	75	18327											
C17orf70	80233	broad.mit.edu	37	chr17	79516305	79516305	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	actctctgtggtcatcctggCtgggccaggcatctcagagt	12	12	3	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr17:79516305C>G	uc002kaq.2	-	4	1385	c.1330G>C	c.(1330-1332)GCC>CCC	p.A444P	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Missense_Mutation_p.A293P	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	444					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GTCATCCTGGCTGGGCCAGGC	0.592													G	79516305	G	G	79516305	3	3	255	1	0	0	0	0	1	0	0	0	1877	797	28	5	1339	5	C17orf70	17	79516305	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	1807397	79516305	1678905	76	18328											
ZNF556	80032	broad.mit.edu	37	chr19	2877392	2877392	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgttgtactagtgtaagaCggtacgaatgcagtcagtgt	12	5	1	1	rs138176298	byFrequency	TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr19:2877392C>T	uc002lwp.1	+	4	523	c.436C>T	c.(436-438)CGG>TGG	p.R146W	ZNF556_uc002lwq.2_Missense_Mutation_p.R145W	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGTGTAAGACGGTACGAATG	0.393													T	2877392	T	T	2877392	3	4	255	1	0	0	0	0	1	0	0	0	17984	527	19	1	450	1	ZNF556	19	2877392	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08		2877392	56251591	77	18329											
MUC16	94025	broad.mit.edu	37	chr19	9047753	9047753	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggactggtgactgtagaaGgcatagtgtctaattcactg	12	7	2	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr19:9047753G>A	uc002mkp.2	-	5	34082	c.33878C>T	c.(33877-33879)CCT>CTT	p.P11293L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11295	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACTGTAGAAGGCATAGTGTC	0.473													A	9047753	A	A	9047753	3	1	255	1	0	0	0	0	1	0	0	0	9973	1000	35	3	9965	3	MUC16	19	9047753	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	6170361	9047753	50081230	78	18330											
SLC1A6	6511	broad.mit.edu	37	chr19	15082585	15082585	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gacaatgagaggtaacaccaGcatctgcagcatcctcatca	8	12	3	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr19:15082585G>T	uc002naa.1	-	2	315	c.307C>A	c.(307-309)CTG>ATG	p.L103M	SLC1A6_uc010dzu.1_Missense_Mutation_p.L103M|SLC1A6_uc010xod.1_Missense_Mutation_p.A107D|SLC1A6_uc002nab.2_Missense_Mutation_p.L103M|SLC1A6_uc002nac.2_Missense_Mutation_p.L103M|SLC1A6_uc002nad.1_Missense_Mutation_p.L103M	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	103	Helical; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	GGTAACACCAGCATCTGCAGC	0.567													T	15082585	T	T	15082585	3	4	255	1	0	0	0	0	1	0	0	0	14436	962	34	5	1419	5	SLC1A6	19	15082585	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	6034832	15082585	44046398	79	18331											
CILP2	148113	broad.mit.edu	37	chr19	19655518	19655518	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtgggcaacgtggagatcCgggagcggcgcctgttcaat	17	9	1	1			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr19:19655518C>T	uc002nmv.3	+	8	2249	c.2164C>T	c.(2164-2166)CGG>TGG	p.R722W	CILP2_uc002nmw.3_Missense_Mutation_p.R728W	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	722						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CGTGGAGATCCGGGAGCGGCG	0.706													T	19655518	T	T	19655518	3	4	255	1	0	0	0	0	1	0	0	0	3430	643	23	2	2194	2	CILP2	19	19655518	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	4572933	19655518	39473465	80	18332											
FGF21	26291	broad.mit.edu	37	chr19	49261318	49261318	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccccacaccgggaccctgcAccccgaggaccagctcgctt	9	20	0	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr19:49261318A>C	uc002pkn.1	+	4	1043	c.471A>C	c.(469-471)GCA>GCC	p.A157A	FUT1_uc002pkk.2_5'Flank|FUT1_uc002pkm.1_5'Flank|FGF21_uc002pko.1_Silent_p.A157A	NM_019113	NP_061986	Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21 precursor	157					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		GGGACCCTGCACCCCGAGGAC	0.682													C	49261318	C	C	49261318	2	2	255	1	0	0	0	0	0	0	0	1	5850	146	6	5		5	FGF21	19	49261318	Silent	SNP	A	TCGA-74-6578-01A-11D-1845-08	29605800	49261318	9867665	81	18333											
PTOV1	53635	broad.mit.edu	37	chr19	50360994	50360996	+	In_Frame_Del	DEL	CAA	-	-													tcaggcccagtccagatcgtCaacaacaagtttctggcatg							TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr19:50360994_50360996delCAA	uc002pqf.1	+	7	929_931	c.759_761delCAA	c.(757-762)GTCAAC>GTC	p.N255del	PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_In_Frame_Del_p.N223del|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	255	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		TCCAGATCGTCAACAACAAGTTT	0.616													-	50360996	-	-	50360994	7	5	255	1	0	1	0	1	0	0	0	0	12769	813	29	0	785	0	PTOV1	19	50360994	In_Frame_Del	DEL	CAA	TCGA-74-6578-01A-11D-1845-08	1099676	50360994	8767989	82	18334											
LILRB5	10990	broad.mit.edu	37	chr19	54758761	54758761	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tactttgactttagacacagCgggggatgggctgccccctc	12	12	0	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr19:54758761C>T	uc002qex.2	-	6	1203	c.1092G>A	c.(1090-1092)CCG>CCA	p.P364P	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Silent_p.P355P|LILRB5_uc002qey.2_Silent_p.P364P|LILRB5_uc002qez.2_Silent_p.P264P|LILRB5_uc002qfa.1_Silent_p.P254P|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	364	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTAGACACAGCGGGGGATGGG	0.547													T	54758761	T	T	54758761	2	4	255	1	0	0	0	0	0	0	0	1	8794	755	27	1		1	LILRB5	19	54758761	Silent	SNP	C	TCGA-74-6578-01A-11D-1845-08	4397767	54758761	4370222	83	18335											
TNNT1	7138	broad.mit.edu	37	chr19	55648558	55648558	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatctcccgccccgtctgcCgcttaccacgcttctgttct	6	19	5	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr19:55648558C>T	uc002qjb.3	-	11	613	c.524G>A	c.(523-525)CGG>CAG	p.R175Q	TNNT1_uc002qiz.3_Missense_Mutation_p.R105Q|TNNT1_uc002qja.3_Missense_Mutation_p.R105Q|TNNT1_uc002qjc.3_Missense_Mutation_p.R175Q|TNNT1_uc002qje.3_Missense_Mutation_p.R164Q|TNNT1_uc002qjd.3_Missense_Mutation_p.R164Q	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	175					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CCCCGTCTGCCGCTTACCACG	0.627													T	55648558	T	T	55648558	3	4	255	1	0	0	0	0	1	0	0	0	16327	652	23	2	328	2	TNNT1	19	55648558	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	889797	55648558	3480425	84	18336											
SNRPB2	6629	broad.mit.edu	37	chr20	16721056	16721056	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgttatccatgctgtttaaTcagtaagttttttcataaat	5	5	2	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr20:16721056T>C	uc002wph.1	+	6	732	c.516T>C	c.(514-516)AAT>AAC	p.N172N	SNRPB2_uc002wpi.1_Silent_p.N172N	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	172	RRM 2.					catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						TGCTGTTTAATCAGTAAGTTT	0.348													C	16721056	C	C	16721056	2	2	255	1	0	0	0	0	0	0	0	1	14862	1432	50	4		4	SNRPB2	20	16721056	Silent	SNP	T	TCGA-74-6578-01A-11D-1845-08		16721056	46304464	85	18337											
NKX2-4	644524	broad.mit.edu	37	chr20	21377636	21377636	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggttggcgccgtaccagccGgtggccgcgccgccccgcat	16	17	0	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr20:21377636G>A	uc010gcz.2	-	1	412	c.402C>T	c.(400-402)ACC>ACT	p.T134T		NM_033176	NP_149416	Q9H2Z4	NKX24_HUMAN	NK2 homeobox 4	134					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGTACCAGCCGGTGGCCGCGC	0.736													A	21377636	A	A	21377636	2	1	255	1	0	0	0	0	0	0	0	1	10452	1103	39	2		2	NKX2-4	20	21377636	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08	4656580	21377636	41647884	86	18338											
CST9	128822	broad.mit.edu	37	chr20	23584188	23584188	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatggctttgtcagctgctcCtgtgcccacaccacacccca	7	17	1	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr20:23584188C>T	uc002wtl.2	-	2	548	c.439G>A	c.(439-441)GGA>AGA	p.G147R		NM_001008693	NP_001008693	Q5W186	CST9_HUMAN	cystatin 9 precursor	147						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Colorectal(13;0.0993)					TCAGCTGCTCCTGTGCCCACA	0.577													T	23584188	T	T	23584188	3	4	255	1	0	0	0	0	1	0	0	0	3979	690	24	3	44	3	CST9	20	23584188	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08	2206552	23584188	39441332	87	18339											
TPTE	7179	broad.mit.edu	37	chr21	10906911	10906911	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggggagctatacttaatcGgatccagctacaacatcact	9	10	1	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr21:10906911G>A	uc002yip.1	-	24	2018	c.1650C>T	c.(1648-1650)TCC>TCT	p.S550S	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.S532S|TPTE_uc002yir.1_Silent_p.S512S|TPTE_uc010gkv.1_Silent_p.S412S	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	550					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATACTTAATCGGATCCAGCTA	0.398													A	10906911	A	A	10906911	2	1	255	1	0	0	0	0	0	0	0	1	16427	1103	39	2		2	TPTE	21	10906911	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08		10906911	37222984	88	18340											
CELSR1	9620	broad.mit.edu	37	chr22	46932243	46932243	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagctcacgcgctcctcctcGccctcgatggtgtagtgcgc	11	16	1	0			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chr22:46932243G>A	uc003bhw.1	-	1	825	c.825C>T	c.(823-825)GGC>GGT	p.G275G		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	275	Extracellular (Potential).|Cadherin 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GCTCCTCCTCGCCCTCGATGG	0.632													A	46932243	A	A	46932243	2	1	255	1	0	0	0	0	0	0	0	1	3221	1074	38	1		1	CELSR1	22	46932243	Silent	SNP	G	TCGA-74-6578-01A-11D-1845-08		46932243	4372323	89	18341											
DACH2	117154	broad.mit.edu	37	chrX	86068163	86068163	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aagttgctttggataatgctCgcatccaggagaagcagatt	11	7	0	2			TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chrX:86068163C>T	uc004eew.2	+	9	1590	c.1420C>T	c.(1420-1422)CGC>TGC	p.R474C	DACH2_uc004eex.2_Missense_Mutation_p.R461C|DACH2_uc010nmq.2_Missense_Mutation_p.R340C|DACH2_uc011mra.1_Missense_Mutation_p.R307C|DACH2_uc010nmr.2_Missense_Mutation_p.R255C|DACH2_uc004eey.2_Missense_Mutation_p.R167C|DACH2_uc004eez.2_Missense_Mutation_p.R157C	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	474	Potential.|DACHbox-C.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						GGATAATGCTCGCATCCAGGA	0.368													T	86068163	T	T	86068163	3	4	255	1	0	0	0	0	1	0	0	0	4221	884	31	2	1454	2	DACH2	23	86068163	Missense_Mutation	SNP	C	TCGA-74-6578-01A-11D-1845-08		86068163	69202397	90	18342											
SLC6A14	11254	broad.mit.edu	37	chrX	115588823	115588823	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcatagacctaattatggcGcaattccataccctgactgg	7	11	1	2	rs142971231		TCGA-74-6578-01A-11D-1845-08	TCGA-74-6578-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a2ae2128-4d95-4261-a30d-bd6be58de8e0	77b7996e-f991-4760-a58d-1a6f7d239ddf	g.chrX:115588823G>A	uc004eqi.2	+	13	1767	c.1663G>A	c.(1663-1665)GCA>ACA	p.A555T		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	555					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TAATTATGGCGCAATTCCATA	0.358													A	115588823	A	A	115588823	3	1	255	1	0	0	0	0	1	0	0	0	14677	1087	38	1	1713	1	SLC6A14	23	115588823	Missense_Mutation	SNP	G	TCGA-74-6578-01A-11D-1845-08	29520660	115588823	39681737	91	18343											
CCDC27	148870	broad.mit.edu	37	chr1	3687985	3687985	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaattatctcagagagaagCgactactataatcagctgaa	8	7	2	4			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr1:3687985C>T	uc001akv.2	+	12	1950	c.1869C>T	c.(1867-1869)AGC>AGT	p.S623S	LOC388588_uc001akw.3_5'Flank	NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	623										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CAGAGAGAAGCGACTACTATA	0.547													T	3687985	T	T	3687985	2	4	256	1	0	0	0	0	0	0	0	1	2801	767	27	1		1	CCDC27	1	3687985	Silent	SNP	C	TCGA-74-6584-01A-11D-1845-08		3687985	245562636	1	18344											
TINAGL1	64129	broad.mit.edu	37	chr1	32049166	32049166	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttcctcggtcatgaacatgcAtgaaatttatgtaagtccat	7	8	1	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr1:32049166A>C	uc001bta.2	+	5	698	c.572A>C	c.(571-573)CAT>CCT	p.H191P	TINAGL1_uc001bsz.2_Missense_Mutation_p.H46P|TINAGL1_uc010ogj.1_Missense_Mutation_p.H160P|TINAGL1_uc010ogk.1_Missense_Mutation_p.H191P	NM_022164	NP_071447	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	191					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		ATGAACATGCATGAAATTTAT	0.582													C	32049166	C	C	32049166	3	2	256	1	0	0	0	0	1	0	0	0	15919	217	8	5	586	5	TINAGL1	1	32049166	Missense_Mutation	SNP	A	TCGA-74-6584-01A-11D-1845-08	28361181	32049166	217201455	2	18345											
RORC	6097	broad.mit.edu	37	chr1	151789175	151789175	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagcgccaggcatttctgcAggcggcagtgctggcatcgg	15	13	1	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr1:151789175A>G	uc001ezh.2	-	4	371	c.263T>C	c.(262-264)CTG>CCG	p.L88P	RORC_uc001ezg.2_Missense_Mutation_p.L67P|RORC_uc010pdo.1_Missense_Mutation_p.L142P|RORC_uc010pdp.1_Missense_Mutation_p.L88P	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	88	NR C4-type.|Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCATTTCTGCAGGCGGCAGTG	0.662													G	151789175	G	G	151789175	3	3	256	1	0	0	0	0	1	0	0	0	13530	188	7	4	1325	4	RORC	1	151789175	Missense_Mutation	SNP	A	TCGA-74-6584-01A-11D-1845-08	119740009	151789175	97461446	3	18346											
HRNR	388697	broad.mit.edu	37	chr1	152185788	152185788	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgaaccagacccgtgtcggcCgtggctaagagactggccag	14	12	0	3			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr1:152185788C>T	uc001ezt.1	-	3	8393	c.8317G>A	c.(8317-8319)GGC>AGC	p.G2773S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2773	30.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGTGTCGGCCGTGGCTAAGA	0.602													T	152185788	T	T	152185788	3	4	256	1	0	0	0	0	1	0	0	0	7359	652	23	2	239	2	HRNR	1	152185788	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08	396613	152185788	97064833	4	18347											
CEP350	9857	broad.mit.edu	37	chr1	180062525	180062525	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctacaagtggagccactagcTttggtagtaatgaggaaatc	11	7	0	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr1:180062525T>A	uc001gnt.2	+	34	7668	c.7285T>A	c.(7285-7287)TTT>ATT	p.F2429I	CEP350_uc009wxl.2_Missense_Mutation_p.F2428I|CEP350_uc001gnv.2_Missense_Mutation_p.F564I|CEP350_uc001gnw.1_Missense_Mutation_p.F186I|CEP350_uc001gnx.1_Missense_Mutation_p.F186I	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2429						centrosome|nucleus|spindle				ovary(4)	4						AGCCACTAGCTTTGGTAGTAA	0.453													A	180062525	A	A	180062525	3	1	256	1	0	0	0	0	1	0	0	0	3254	1609	56	5	7415	5	CEP350	1	180062525	Missense_Mutation	SNP	T	TCGA-74-6584-01A-11D-1845-08	27876737	180062525	69188096	5	18348											
ADCY3	109	broad.mit.edu	37	chr2	25044464	25044464	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catggccagcgcgaagtcggCcaggtcagccaggtgctgcc	15	14	1	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr2:25044464C>T	uc002rfs.3	-	19	3248	c.3049G>A	c.(3049-3051)GCC>ACC	p.A1017T	ADCY3_uc002rfr.3_Missense_Mutation_p.A604T|ADCY3_uc010ykm.1_Missense_Mutation_p.A1018T	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	1017	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GCGAAGTCGGCCAGGTCAGCC	0.607													T	25044464	T	T	25044464	3	4	256	1	0	0	0	0	1	0	0	0	295	739	26	3	397	3	ADCY3	2	25044464	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08		25044464	218154909	6	18349											
C2orf55	343990	broad.mit.edu	37	chr2	99438371	99438371	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgtcctgggctccttcctggGttcccgctctcccgggccgg	13	18	1	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr2:99438371G>T	uc002szf.1	-	7	2659	c.2365C>A	c.(2365-2367)CCC>ACC	p.P789T		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	789	Pro-rich.										0						TCCTTCCTGGGTTCCCGCTCT	0.736													T	99438371	T	T	99438371	3	4	256	1	0	0	0	0	1	0	0	0	2176	1261	44	5	539	5	C2orf55	2	99438371	Missense_Mutation	SNP	G	TCGA-74-6584-01A-11D-1845-08	74393907	99438371	143761002	7	18350											
BOLL	66037	broad.mit.edu	37	chr2	198643759	198643759	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctttcacagacccatactggGaaaaaaattttcttaaatca	4	9	3	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr2:198643759G>A	uc002uus.2	-	3	471	c.161C>T	c.(160-162)TCC>TTC	p.S54F	BOLL_uc002uur.2_Missense_Mutation_p.S60F|BOLL_uc002uut.2_Missense_Mutation_p.S66F|BOLL_uc010zha.1_5'UTR|BOLL_uc002uuu.1_Missense_Mutation_p.S60F	NM_033030	NP_149019	Q8N9W6	BOLL_HUMAN	boule isoform 2	54	RRM.				cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2						CCCATACTGGGAAAAAAATTT	0.318													A	198643759	A	A	198643759	3	1	256	1	0	0	0	0	1	0	0	0	1487	1174	41	3	726	3	BOLL	2	198643759	Missense_Mutation	SNP	G	TCGA-74-6584-01A-11D-1845-08	99205388	198643759	44555614	8	18351											
OR5AC2	81050	broad.mit.edu	37	chr3	97806212	97806212	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcccatgtacttattccttGgtggtttagccttttcagat	8	9	1	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr3:97806212G>A	uc011bgs.1	+	1	196	c.196G>A	c.(196-198)GGT>AGT	p.G66S		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTTATTCCTTGGTGGTTTAGC	0.438													A	97806212	A	A	97806212	3	1	256	1	0	0	0	0	1	0	0	0	11141	1348	47	3	198	3	OR5AC2	3	97806212	Missense_Mutation	SNP	G	TCGA-74-6584-01A-11D-1845-08		97806212	100216218	9	18352											
SENP7	57337	broad.mit.edu	37	chr3	101046635	101046635	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgacgatgagtttttagttTaacttcccactctacctcta	5	10	2	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr3:101046635T>C	uc003dut.2	-	23	3001	c.2890A>G	c.(2890-2892)AAA>GAA	p.K964E	SENP7_uc003duu.2_Missense_Mutation_p.K899E|SENP7_uc003duv.2_Missense_Mutation_p.K931E|SENP7_uc003duw.2_Missense_Mutation_p.K898E|SENP7_uc003dux.2_Missense_Mutation_p.K800E|SENP7_uc003dus.2_Missense_Mutation_p.K152E	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	964	Protease.				proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						GTTTTTAGTTTAACTTCCCAC	0.338													C	101046635	C	C	101046635	3	2	256	1	0	0	0	0	1	0	0	0	14051	1763	61	4	270	4	SENP7	3	101046635	Missense_Mutation	SNP	T	TCGA-74-6584-01A-11D-1845-08	3240423	101046635	96975795	10	18353											
AADAC	13	broad.mit.edu	37	chr3	151545690	151545690	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agttctgagctggctaaaaaAtatccagggttcctagatgt	10	7	1	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr3:151545690A>G	uc003eze.2	+	5	1020	c.930A>G	c.(928-930)AAA>AAG	p.K310K		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	310	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TGGCTAAAAAATATCCAGGGT	0.418													G	151545690	G	G	151545690	2	3	256	1	0	0	0	0	0	0	0	1	10	98	4	4		4	AADAC	3	151545690	Silent	SNP	A	TCGA-74-6584-01A-11D-1845-08	50499055	151545690	46476740	11	18354											
ATOH1	474	broad.mit.edu	37	chr4	94750754	94750754	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggaggggaacagccaccgcCgcctccagcctcctgcaaaa	11	17	0	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr4:94750754C>T	uc003hta.1	+	1	677	c.677C>T	c.(676-678)CCG>CTG	p.P226L		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	226	Poly-Pro.				transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CAGCCACCGCCGCCTCCAGCC	0.632													T	94750754	T	T	94750754	3	4	256	1	0	0	0	0	1	0	0	0	1112	652	23	2	679	2	ATOH1	4	94750754	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08		94750754	96403522	12	18355											
ZNF827	152485	broad.mit.edu	37	chr4	146791485	146791485	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttcctggggctttagtgcGtcctcagagacgcctggggc	14	13	1	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr4:146791485G>A	uc003ikn.2	-	5	1941	c.1893C>T	c.(1891-1893)GAC>GAT	p.D631D	ZNF827_uc003ikm.2_Silent_p.D631D|ZNF827_uc010iox.2_Silent_p.D281D	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	631					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					GCTTTAGTGCGTCCTCAGAGA	0.537													A	146791485	A	A	146791485	2	1	256	1	0	0	0	0	0	0	0	1	18177	1136	40	1		1	ZNF827	4	146791485	Silent	SNP	G	TCGA-74-6584-01A-11D-1845-08	52040731	146791485	44362791	13	18356											
IL31RA	133396	broad.mit.edu	37	chr5	55203287	55203287	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggcttatgccaaagaaggCggtatgaatggacaagaccc	12	9	0	3			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr5:55203287C>T	uc003jql.2	+	10	1418	c.1353C>T	c.(1351-1353)GGC>GGT	p.G451G	IL31RA_uc003jqk.2_Silent_p.G451G|IL31RA_uc011cqj.1_Silent_p.G309G|IL31RA_uc003jqm.2_Silent_p.G419G|IL31RA_uc003jqn.2_Silent_p.G451G|IL31RA_uc010iwa.1_Silent_p.G419G|IL31RA_uc003jqo.2_Silent_p.G309G	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	419	Extracellular (Potential).				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				CCAAAGAAGGCGGTATGAATG	0.463													T	55203287	T	T	55203287	2	4	256	1	0	0	0	0	0	0	0	1	7691	782	27	1		1	IL31RA	5	55203287	Silent	SNP	C	TCGA-74-6584-01A-11D-1845-08		55203287	125711973	14	18357											
FBN2	2201	broad.mit.edu	37	chr5	127624839	127624839	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccacacagcgtactccagtgTagtcaaggttgtagcccatt	9	12	1	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr5:127624839T>C	uc003kuu.2	-	52	7056	c.6617A>G	c.(6616-6618)TAC>TGC	p.Y2206C		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2206	EGF-like 36; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TACTCCAGTGTAGTCAAGGTT	0.428													C	127624839	C	C	127624839	3	2	256	1	0	0	0	0	1	0	0	0	5703	1638	57	4	2177	4	FBN2	5	127624839	Missense_Mutation	SNP	T	TCGA-74-6584-01A-11D-1845-08	72421552	127624839	53290421	15	18358											
DSP	1832	broad.mit.edu	37	chr6	7581687	7581687	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catcttggaactaaggagccAgctgcagatcagcaacaacc	9	12	2	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr6:7581687A>T	uc003mxp.1	+	23	5543	c.5264A>T	c.(5263-5265)CAG>CTG	p.Q1755L	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1755	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTAAGGAGCCAGCTGCAGATC	0.483													T	7581687	T	T	7581687	3	4	256	1	0	0	0	0	1	0	0	0	4781	188	7	5	5354	5	DSP	6	7581687	Missense_Mutation	SNP	A	TCGA-74-6584-01A-11D-1845-08		7581687	163533380	16	18359											
ZNF184	7738	broad.mit.edu	37	chr6	27419109	27419109	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccaggatgcagtctctgatgTttgttgagagcagagcgata	13	7	1	3			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr6:27419109T>C	uc003njj.2	-	5	3040	c.2229A>G	c.(2227-2229)AAA>AAG	p.K743K	ZNF184_uc010jqv.2_Silent_p.K743K|ZNF184_uc003nji.2_Silent_p.K743K	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	743	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTCTCTGATGTTTGTTGAGAG	0.378													C	27419109	C	C	27419109	2	2	256	1	0	0	0	0	0	0	0	1	17748	1722	60	4		4	ZNF184	6	27419109	Silent	SNP	T	TCGA-74-6584-01A-11D-1845-08	19837422	27419109	143695958	17	18360											
PKHD1	5314	broad.mit.edu	37	chr6	51777281	51777281	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgatgacaacttcatccccaGggttccagtccacagcatct	7	14	2	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr6:51777281G>T	uc003pah.1	-	38	6491	c.6215C>A	c.(6214-6216)CCT>CAT	p.P2072H	PKHD1_uc010jzn.1_Missense_Mutation_p.P97H|PKHD1_uc003pai.2_Missense_Mutation_p.P2072H	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2072	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TTCATCCCCAGGGTTCCAGTC	0.478													T	51777281	T	T	51777281	3	4	256	1	0	0	0	0	1	0	0	0	11971	1000	35	5	6168	5	PKHD1	6	51777281	Missense_Mutation	SNP	G	TCGA-74-6584-01A-11D-1845-08	24358172	51777281	119337786	18	18361											
PKHD1	5314	broad.mit.edu	37	chr6	51947232	51947232	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcaaatccaagaaaacaggaAagacgtcacagggaacactc	9	10	1	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr6:51947232A>G	uc003pah.1	-	4	515	c.239T>C	c.(238-240)TTT>TCT	p.F80S	PKHD1_uc003pai.2_Missense_Mutation_p.F80S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	80	Extracellular (Potential).|IPT/TIG 1; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GAAAACAGGAAAGACGTCACA	0.502													G	51947232	G	G	51947232	3	3	256	1	0	0	0	0	1	0	0	0	11971	14	1	4	12280	4	PKHD1	6	51947232	Missense_Mutation	SNP	A	TCGA-74-6584-01A-11D-1845-08	169951	51947232	119167835	19	18362											
COL10A1	1300	broad.mit.edu	37	chr6	116442879	116442879	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggccccggggtcctggtaGgccagctggtccaacatctc	14	14	1	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr6:116442879G>A	uc003pwm.2	-	3	496	c.400C>T	c.(400-402)CTA>TTA	p.L134L	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	134	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		GGTCCTGGTAGGCCAGCTGGT	0.602													A	116442879	A	A	116442879	2	1	256	1	0	0	0	0	0	0	0	1	3666	991	35	3		3	COL10A1	6	116442879	Silent	SNP	G	TCGA-74-6584-01A-11D-1845-08	64495647	116442879	54672188	20	18363											
TMEM195	392636	broad.mit.edu	37	chr7	15599842	15599842	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	acctggtggctttcctttgaGaatccagctgacaacaagtt	9	10	0	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr7:15599842G>T	uc003stb.1	-	2	351	c.181C>A	c.(181-183)CTC>ATC	p.L61I		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	61	Helical; (Potential).				ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TTTCCTTTGAGAATCCAGCTG	0.438													T	15599842	T	T	15599842	3	4	256	1	0	0	0	0	1	0	0	0	16114	942	33	5	1204	5	TMEM195	7	15599842	Missense_Mutation	SNP	G	TCGA-74-6584-01A-11D-1845-08		15599842	143538821	21	18364											
COBL	23242	broad.mit.edu	37	chr7	51287539	51287539	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttcatgcgaaccaagttctgCtgcgacccgagggccccatc	10	15	2	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr7:51287539C>A	uc003tpr.3	-	2	329	c.144G>T	c.(142-144)CAG>CAT	p.Q48H	COBL_uc003tps.2_Missense_Mutation_p.Q48H|COBL_uc011kcl.1_Missense_Mutation_p.Q48H|COBL_uc010kzc.2_Missense_Mutation_p.Q48H|COBL_uc003tpt.2_Missense_Mutation_p.Q48H	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	48										skin(3)|ovary(2)	5	Glioma(55;0.08)					CCAAGTTCTGCTGCGACCCGA	0.632													A	51287539	A	A	51287539	3	1	256	1	0	0	0	0	1	0	0	0	3653	796	28	5	3689	5	COBL	7	51287539	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08	35687697	51287539	107851124	22	18365											
PHF2	5253	broad.mit.edu	37	chr9	96421820	96421820	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagagcatgaggacgagctcCcggagcacttcaaaccttca	10	13	2	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr9:96421820C>T	uc004aub.2	+	11	1414	c.1267C>T	c.(1267-1269)CCG>TCG	p.P423S	PHF2_uc011lug.1_Missense_Mutation_p.P306S	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	423					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		GGACGAGCTCCCGGAGCACTT	0.612													T	96421820	T	T	96421820	3	4	256	1	0	0	0	0	1	0	0	0	11830	623	22	3	1309	3	PHF2	9	96421820	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08		96421820	44791611	23	18366											
LPAR1	1902	broad.mit.edu	37	chr9	113703965	113703965	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgggtatagcacccataaCgatggccatagtccagatga	10	10	0	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr9:113703965C>T	uc004bfa.2	-	4	784	c.529G>A	c.(529-531)GTT>ATT	p.V177I	LPAR1_uc011lwm.1_Missense_Mutation_p.V178I|LPAR1_uc004bfb.2_Missense_Mutation_p.V177I|LPAR1_uc004bfc.2_Missense_Mutation_p.V177I|LPAR1_uc011lwn.1_Missense_Mutation_p.V159I|LPAR1_uc011lwo.1_Missense_Mutation_p.V178I|LPAR1_uc010mub.2_Missense_Mutation_p.V177I	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	177	Helical; Name=4; (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GCACCCATAACGATGGCCATA	0.498													T	113703965	T	T	113703965	3	4	256	1	0	0	0	0	1	0	0	0	8904	536	19	1	573	1	LPAR1	9	113703965	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08	17282145	113703965	27509466	24	18367											
CEP110	11064	broad.mit.edu	37	chr9	123930543	123930543	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agctgaagagcgtgttaggaCtctgcaggaagaggagaggt	17	5	1	4			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr9:123930543C>G	uc004bkx.1	+	36	6045	c.6014C>G	c.(6013-6015)ACT>AGT	p.T2005S	CEP110_uc004blb.1_Missense_Mutation_p.T674S|CEP110_uc010mvp.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	2005	Required for centrosome localization.|Sufficient for interaction with HOOK2.|Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						CGTGTTAGGACTCTGCAGGAA	0.498													G	123930543	G	G	123930543	3	3	256	1	0	0	0	0	1	0	0	0	3245	565	20	5	6156	5	CEP110	9	123930543	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08	10226578	123930543	17282888	25	18368											
SUFU	51684	broad.mit.edu	37	chr10	104353785	104353785	+	Frame_Shift_Del	DEL	G	-	-													gctgataactgacatgcggaGgggagagaccatatttgaga							TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr10:104353785delG	uc001kvy.1	+	6	865	c.719delG	c.(718-720)AGGfs	p.R240fs	SUFU_uc001kvw.1_Frame_Shift_Del_p.R240fs|SUFU_uc001kvx.2_Frame_Shift_Del_p.R240fs|SUFU_uc009xxe.1_5'Flank|SUFU_uc009xxf.1_5'Flank	NM_016169	NP_057253	Q9UMX1	SUFU_HUMAN	suppressor of fused	240					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			central_nervous_system(4)|skin(2)|breast(1)	7		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		GACATGCGGAGGGGAGAGACC	0.532			D|F|S		medulloblastoma	medulloblastoma			Medulloblastoma_associated_with_Germline_SUFU_Mutation				-	104353785	-	-	104353785	7	5	256	1	0	1	0	1	0	0	0	0	15367	1000	35	0	741	0	SUFU	10	104353785	Frame_Shift_Del	DEL	G	TCGA-74-6584-01A-11D-1845-08		104353785	31180962	26	18369											
C10orf79	80217	broad.mit.edu	37	chr10	105906078	105906078	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacacatccaggtcttctctAgatttccgaacagcttctga	6	13	3	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr10:105906078A>G	uc001kxw.2	-	30	3914	c.3798T>C	c.(3796-3798)TCT>TCC	p.S1266S	C10orf79_uc009xxq.2_Intron	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1266											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		GGTCTTCTCTAGATTTCCGAA	0.418													G	105906078	G	G	105906078	2	3	256	1	0	0	0	0	0	0	0	1	1618	407	15	4		4	C10orf79	10	105906078	Silent	SNP	A	TCGA-74-6584-01A-11D-1845-08	1552293	105906078	29628669	27	18370											
SIGIRR	59307	broad.mit.edu	37	chr11	408155	408155	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagacttcagtgctggtcacGttgacccccaggacactgga	11	12	2	2	rs142561304		TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr11:408155G>A	uc001lpd.2	-	4	588	c.258C>T	c.(256-258)AAC>AAT	p.N86N	SIGIRR_uc001lpf.2_Silent_p.N86N|SIGIRR_uc001lpe.1_Silent_p.N86N|SIGIRR_uc001lpg.2_Silent_p.N86N	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	86	Ig-like C2-type.|Extracellular (Potential).				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGCTGGTCACGTTGACCCCCA	0.577													A	408155	A	A	408155	2	1	256	1	0	0	0	0	0	0	0	1	14304	1136	40	1		1	SIGIRR	11	408155	Silent	SNP	G	TCGA-74-6584-01A-11D-1845-08		408155	134598361	28	18371											
OR10AG1	282770	broad.mit.edu	37	chr11	55735664	55735664	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaagcataagaaaaaaacaCatttgtgtagcacaagcaaa	6	8	0	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr11:55735664C>T	uc010rit.1	-	1	276	c.276G>A	c.(274-276)ATG>ATA	p.M92I		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	92	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GAAAAAAACACATTTGTGTAG	0.403													T	55735664	T	T	55735664	3	4	256	1	0	0	0	0	1	0	0	0	10897	478	17	3	632	3	OR10AG1	11	55735664	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08	55327509	55735664	79270852	29	18372											
DDI1	414301	broad.mit.edu	37	chr11	103908618	103908618	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcatcggcaccactggcacGcagacttattttcttcctga	8	13	2	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr11:103908618G>A	uc001phr.2	+	1	1311	c.1068G>A	c.(1066-1068)ACG>ACA	p.T356T	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	356					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CCACTGGCACGCAGACTTATT	0.463													A	103908618	A	A	103908618	2	1	256	1	0	0	0	0	0	0	0	1	4328	1074	38	1		1	DDI1	11	103908618	Silent	SNP	G	TCGA-74-6584-01A-11D-1845-08	48172954	103908618	31097898	30	18373											
MMP19	4327	broad.mit.edu	37	chr12	56230872	56230872	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagtggtatccaaggttatgCccgtacctgagggagtggta	15	7	0	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr12:56230872C>T	uc001sib.2	-	9	1596	c.1475G>A	c.(1474-1476)GGC>GAC	p.G492D	MMP19_uc001sia.2_Missense_Mutation_p.G206D|MMP19_uc001sid.2_RNA|MMP19_uc010spw.1_3'UTR	NM_002429	NP_002420	Q99542	MMP19_HUMAN	matrix metalloproteinase 19 isoform rasi-1	492					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)	1						CAAGGTTATGCCCGTACCTGA	0.507													T	56230872	T	T	56230872	3	4	256	1	0	0	0	0	1	0	0	0	9657	739	26	3	55	3	MMP19	12	56230872	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08		56230872	77621023	31	18374											
PLXNC1	10154	broad.mit.edu	37	chr12	94654582	94654582	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cgtcgaaaaactcctcacaaActggatgtccgtctgccttt	7	13	2	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr12:94654582A>T	uc001tdc.2	+	20	3665	c.3416A>T	c.(3415-3417)AAC>ATC	p.N1139I	PLXNC1_uc010sut.1_Missense_Mutation_p.N186I|PLXNC1_uc009zsv.2_5'Flank	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1139	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CTCCTCACAAACTGGATGTCC	0.498													T	94654582	T	T	94654582	3	4	256	1	0	0	0	0	1	0	0	0	12126	43	2	5	3494	5	PLXNC1	12	94654582	Missense_Mutation	SNP	A	TCGA-74-6584-01A-11D-1845-08	38423710	94654582	39197313	32	18375											
COL4A2	1284	broad.mit.edu	37	chr13	111084708	111084708	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggaccaaaaggacagcaaGtaagttggttttggggggtg	16	5	0	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr13:111084708G>A	uc001vqx.2	+	11	973	c.684_splice	c.e11+1	p.Q228_splice		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein						angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGGACAGCAAGTAAGTTGGTT	0.438													A	111084708	A	A	111084708	5	1	256	1	0	0	0	0	0	0	1	0	3690	1043	36	3	723	3	COL4A2	13	111084708	Splice_Site	SNP	G	TCGA-74-6584-01A-11D-1845-08		111084708	4085170	33	18376											
PTGR2	145482	broad.mit.edu	37	chr14	74346839	74346839	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cttatcctcccccgctatccCctgctatagaggcaatccag	6	17	0	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr14:74346839C>G	uc001xow.2	+	7	971	c.811C>G	c.(811-813)CCT>GCT	p.P271A	PTGR2_uc010tue.1_Missense_Mutation_p.P271A|PTGR2_uc001xox.2_Missense_Mutation_p.P271A|ZNF410_uc001xoy.1_RNA	NM_001146154	NP_001139626	Q8N8N7	PTGR2_HUMAN	prostaglandin reductase 2	271					prostaglandin metabolic process		15-oxoprostaglandin 13-oxidase activity|zinc ion binding				0						CCCGCTATCCCCTGCTATAGA	0.413													G	74346839	G	G	74346839	3	3	256	1	0	0	0	0	1	0	0	0	12754	623	22	5	833	5	PTGR2	14	74346839	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08		74346839	33002701	34	18377											
MFAP1	4236	broad.mit.edu	37	chr15	44106722	44106722	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cgaatgaagactggcttaagGcgaggctccatctcatcttc	10	11	2	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr15:44106722G>T	uc001zth.1	-	4	778	c.594C>A	c.(592-594)CGC>CGA	p.R198R		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	198						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		CTGGCTTAAGGCGAGGCTCCA	0.448													T	44106722	T	T	44106722	2	4	256	1	0	0	0	0	0	0	0	1	9513	1190	42	5		5	MFAP1	15	44106722	Silent	SNP	G	TCGA-74-6584-01A-11D-1845-08		44106722	58424670	35	18378											
VWA3A	146177	broad.mit.edu	37	chr16	22149825	22149825	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcccaccgtccccctggggGccagaatggtttgactcccc	12	17	0	2			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr16:22149825G>A	uc010vbq.1	+	22	2380	c.2284G>A	c.(2284-2286)GCC>ACC	p.A762T	VWA3A_uc010bxd.2_RNA|VWA3A_uc010bxc.2_Missense_Mutation_p.A770T	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	762						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		CCCCCTGGGGGCCAGAATGGT	0.537													A	22149825	A	A	22149825	3	1	256	1	0	0	0	0	1	0	0	0	17237	1203	42	3	2370	3	VWA3A	16	22149825	Missense_Mutation	SNP	G	TCGA-74-6584-01A-11D-1845-08		22149825	68204928	36	18379											
STX1B	112755	broad.mit.edu	37	chr16	31004532	31004532	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtccacagaatgttccacGttgtactcgatgcggtcaat	9	10	1	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr16:31004532G>A	uc010cad.2	-	9	817	c.705C>T	c.(703-705)AAC>AAT	p.N235N	STX1B_uc010vfd.1_Silent_p.N235N	NM_052874	NP_443106	P61266	STX1B_HUMAN	syntaxin 1B	235	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|neurotransmitter transport|synaptic transmission	integral to plasma membrane	extracellular-glutamate-gated ion channel activity|SNAP receptor activity				0						AATGTTCCACGTTGTACTCGA	0.602													A	31004532	A	A	31004532	2	1	256	1	0	0	0	0	0	0	0	1	15343	1136	40	1		1	STX1B	16	31004532	Silent	SNP	G	TCGA-74-6584-01A-11D-1845-08	8854707	31004532	59350221	37	18380											
FAM92B	339145	broad.mit.edu	37	chr16	85132864	85132864	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggctggctgccccttaaccAcccactcacagagactaaac	8	16	1	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr16:85132864A>C	uc010vok.1	-	8	998	c.842T>G	c.(841-843)GTA>GGA	p.V281G		NM_198491	NP_940893	Q6ZTR7	FA92B_HUMAN	hypothetical protein LOC339145	281										central_nervous_system(1)	1						CCCCTTAACCACCCACTCACA	0.318													C	85132864	C	C	85132864	3	2	256	1	0	0	0	0	1	0	0	0	5653	159	6	5	76	5	FAM92B	16	85132864	Missense_Mutation	SNP	A	TCGA-74-6584-01A-11D-1845-08	54128332	85132864	5221889	38	18381											
FOXN1	8456	broad.mit.edu	37	chr17	26864216	26864216	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcatccccgacatcatcttCgatgccaccaccccagccac	4	21	3	0			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr17:26864216C>T	uc010crm.2	+	9	1907	c.1709C>T	c.(1708-1710)TCG>TTG	p.S570L	FOXN1_uc002hbj.2_Missense_Mutation_p.S570L	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	570					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					ACATCATCTTCGATGCCACCA	0.612													T	26864216	T	T	26864216	3	4	256	1	0	0	0	0	1	0	0	0	6019	893	31	2	1739	2	FOXN1	17	26864216	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08		26864216	54330994	39	18382											
THOC1	9984	broad.mit.edu	37	chr18	225100	225100	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aacacatacctctaccatctTtgaaaatctttctccatcgg	3	13	4	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr18:225100T>C	uc002kkj.3	-	14	1166	c.1126A>G	c.(1126-1128)AAG>GAG	p.K376E	THOC1_uc002kkk.3_RNA|THOC1_uc002kkl.2_3'UTR|THOC1_uc002kkh.3_5'UTR	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	THO complex 1	376					apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				TCTACCATCTTTGAAAATCTT	0.363													C	225100	C	C	225100	3	2	256	1	0	0	0	0	1	0	0	0	15861	1850	64	4	879	4	THOC1	18	225100	Missense_Mutation	SNP	T	TCGA-74-6584-01A-11D-1845-08		225100	77852148	40	18383											
CEACAM7	1087	broad.mit.edu	37	chr19	42187745	42187745	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcagggtgactgggtcactgCggctggcacccactgggttc	15	12	2	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr19:42187745C>T	uc002ori.1	-	3	679	c.677G>A	c.(676-678)CGC>CAC	p.R226H	CEACAM7_uc010ehx.2_Missense_Mutation_p.R226H|CEACAM7_uc010ehy.1_Intron	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	226	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		TGGGTCACTGCGGCTGGCACC	0.547													T	42187745	T	T	42187745	3	4	256	1	0	0	0	0	1	0	0	0	3197	768	27	1	128	1	CEACAM7	19	42187745	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08		42187745	16941238	41	18384											
NLRP12	91662	broad.mit.edu	37	chr19	54313743	54313743	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggctcgttgtccctcacGtaattgaagacttggcccgc	11	12	1	3	rs146245368	byFrequency	TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr19:54313743G>A	uc002qch.3	-	3	1390	c.1170C>T	c.(1168-1170)TAC>TAT	p.Y390Y	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.Y390Y|NLRP12_uc002qcj.3_Silent_p.Y390Y|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.Y390Y	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	390	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TGTCCCTCACGTAATTGAAGA	0.567													A	54313743	A	A	54313743	2	1	256	1	0	0	0	0	0	0	0	1	10474	1140	40	1		1	NLRP12	19	54313743	Silent	SNP	G	TCGA-74-6584-01A-11D-1845-08	12125998	54313743	4815240	42	18385											
FASTKD5	60493	broad.mit.edu	37	chr20	3128199	3128199	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccttaaggaggtcaaacttAgttctctcctgagctaacct	7	11	2	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chr20:3128199A>C	uc002whz.2	-	2	1829	c.1518T>G	c.(1516-1518)ACT>ACG	p.T506T	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	506					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						GGTCAAACTTAGTTCTCTCCT	0.468													C	3128199	C	C	3128199	2	2	256	1	0	0	0	0	0	0	0	1	5688	407	15	5		5	FASTKD5	20	3128199	Silent	SNP	A	TCGA-74-6584-01A-11D-1845-08		3128199	59897321	43	18386											
DCAF8L1	139425	broad.mit.edu	37	chrX	27999269	27999269	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgattttctgtgctggcatcGttcaggaaaccaccatccct	8	12	2	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chrX:27999269G>A	uc004dbx.1	-	1	298	c.183C>T	c.(181-183)AAC>AAT	p.N61N		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	61										ovary(3)|skin(1)	4						TGCTGGCATCGTTCAGGAAAC	0.507													A	27999269	A	A	27999269	2	1	256	1	0	0	0	0	0	0	0	1	4277	1136	40	1		1	DCAF8L1	23	27999269	Silent	SNP	G	TCGA-74-6584-01A-11D-1845-08		27999269	127271291	44	18387											
SSX5	6758	broad.mit.edu	37	chrX	48053576	48053576	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctactcaccctgattcccaCggttagggtcattatcaaaa	6	12	4	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chrX:48053576C>T	uc004dja.1	-	4	322	c.269G>A	c.(268-270)CGT>CAT	p.R90H	SSX5_uc004diz.1_Missense_Mutation_p.R131H	NM_175723	NP_783729	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5 isoform b	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						CTGATTCCCACGGTTAGGGTC	0.498													T	48053576	T	T	48053576	3	4	256	1	0	0	0	0	1	0	0	0	15207	536	19	1	313	1	SSX5	23	48053576	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08	20054307	48053576	107216984	45	18388											
MUM1L1	139221	broad.mit.edu	37	chrX	105450536	105450536	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttaatctttctctattagatGatgatgaggaagacgaagaa	9	4	2	6			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chrX:105450536G>A	uc004emf.1	+	4	1760	c.1111G>A	c.(1111-1113)GAT>AAT	p.D371N	MUM1L1_uc004emg.1_Missense_Mutation_p.D371N	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	371										ovary(2)|pancreas(1)|skin(1)	4						TCTATTAGATGATGATGAGGA	0.368													A	105450536	A	A	105450536	3	1	256	1	0	0	0	0	1	0	0	0	9986	1290	45	3	1113	3	MUM1L1	23	105450536	Missense_Mutation	SNP	G	TCGA-74-6584-01A-11D-1845-08	57396960	105450536	49820024	46	18389											
LAMP2	3920	broad.mit.edu	37	chrX	119589247	119589247	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	caggaaatgttgtgttatcaCcagtgttgtaggaaaatgag	12	4	1	1			TCGA-74-6584-01A-11D-1845-08	TCGA-74-6584-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	cedd2d49-371b-4b12-8aac-6a9bd38f2ccb	36de64d8-7be2-44eb-bbfc-d3c0c885ce94	g.chrX:119589247C>A	uc004est.3	-	3	542	c.362G>T	c.(361-363)GGT>GTT	p.G121V	LAMP2_uc004ess.3_Missense_Mutation_p.G121V|LAMP2_uc011mtz.1_Intron|LAMP2_uc011mua.1_Missense_Mutation_p.G74V|LAMP2_uc010nqp.1_Missense_Mutation_p.G121V	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	121	Lumenal (Potential).|First lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						TGTGTTATCACCAGTGTTGTA	0.363													A	119589247	A	A	119589247	3	1	256	1	0	0	0	0	1	0	0	0	8618	507	18	5	1189	5	LAMP2	23	119589247	Missense_Mutation	SNP	C	TCGA-74-6584-01A-11D-1845-08	14138711	119589247	35681313	47	18390											
CASZ1	54897	broad.mit.edu	37	chr1	10699777	10699777	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggggcagtcggcgaagtggCagctgagtgaggccttgaag	19	7	0	3			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr1:10699777C>T	uc001aro.2	-	21	4822	c.4502G>A	c.(4501-4503)TGC>TAC	p.C1501Y		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1501				C -> R (in Ref. 2; ABB29845).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGCGAAGTGGCAGCTGAGTGA	0.657													T	10699777	T	T	10699777	3	4	257	1	0	0	0	0	1	0	0	0	2685	710	25	3	781	3	CASZ1	1	10699777	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		10699777	238550844	1	18391											
NCDN	23154	broad.mit.edu	37	chr1	36026428	36026431	+	Frame_Shift_Del	DEL	AGTG	-	-													tggccgtgttgcggggcctcAgtgaggatttccagaaagct							TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr1:36026428_36026431delAGTG	uc001bza.2	+	4	803_806	c.676_679delAGTG	c.(676-681)AGTGAGfs	p.S226fs	KIAA0319L_uc010ohw.1_5'Flank|NCDN_uc001bzb.2_Frame_Shift_Del_p.S226fs|NCDN_uc001bzc.2_Frame_Shift_Del_p.S209fs	NM_001014839	NP_001014839	Q9UBB6	NCDN_HUMAN	neurochondrin isoform 1	226_227					neuron projection development	cytosol|dendrite|neuronal cell body				large_intestine(2)|pancreas(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCGGGGCCTCAGTGAGGATTTCCA	0.642													-	36026431	-	-	36026428	7	5	257	1	0	1	0	1	0	0	0	0	10214	188	7	0	686	0	NCDN	1	36026428	Frame_Shift_Del	DEL	AGTG	TCGA-76-4925-01A-01D-1486-08	25326651	36026428	213224193	2	18392											
TOE1	114034	broad.mit.edu	37	chr1	45807217	45807217	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atcctttccctgggcctcgcCtgcttcaagcggcagccaga	10	16	1	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr1:45807217C>G	uc009vxq.2	+	4	892	c.309C>G	c.(307-309)GCC>GCG	p.A103A	MUTYH_uc001cnf.2_5'Flank|MUTYH_uc009vxo.2_5'Flank|MUTYH_uc001cng.2_5'Flank|MUTYH_uc001cnj.2_5'Flank|MUTYH_uc001cni.2_5'Flank|MUTYH_uc001cnh.2_5'Flank|MUTYH_uc001cno.2_5'Flank|MUTYH_uc001cnk.2_5'Flank|MUTYH_uc010oll.1_5'Flank|MUTYH_uc001cnm.2_5'Flank|MUTYH_uc001cnl.2_5'Flank|MUTYH_uc009vxp.2_5'Flank|MUTYH_uc001cnn.2_5'Flank|TOE1_uc001cnq.3_RNA|TOE1_uc010olm.1_Intron|TOE1_uc010oln.1_Silent_p.A109A|TOE1_uc001cnr.3_RNA	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	103						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGGGCCTCGCCTGCTTCAAGC	0.562													G	45807217	G	G	45807217	2	3	257	1	0	0	0	0	0	0	0	1	16346	668	24	5		5	TOE1	1	45807217	Silent	SNP	C	TCGA-76-4925-01A-01D-1486-08	9780789	45807217	203443404	3	18393											
MCOLN3	55283	broad.mit.edu	37	chr1	85491656	85491656	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccatttttagaattgatccaAtgattgtcaatatgtcacta	5	7	2	3			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr1:85491656A>G	uc001dkp.2	-	9	1154	c.1061T>C	c.(1060-1062)ATT>ACT	p.I354T	MCOLN3_uc001dko.2_5'Flank|MCOLN3_uc001dkq.2_Missense_Mutation_p.I298T|MCOLN3_uc001dkr.2_3'UTR|MCOLN3_uc001dks.3_Missense_Mutation_p.I199T	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	354	Helical; (Potential).					integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		AATTGATCCAATGATTGTCAA	0.303													G	85491656	G	G	85491656	3	3	257	1	0	0	0	0	1	0	0	0	9397	101	4	4	620	4	MCOLN3	1	85491656	Missense_Mutation	SNP	A	TCGA-76-4925-01A-01D-1486-08	39684439	85491656	163758965	4	18394											
HFM1	164045	broad.mit.edu	37	chr1	91739356	91739356	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cattataggcaattcagataTgtttaaatattctgaccttt	5	6	2	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr1:91739356T>C	uc001doa.3	-	34	3785	c.3685A>G	c.(3685-3687)ATA>GTA	p.I1229V	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.I908V|HFM1_uc001dob.3_Missense_Mutation_p.I417V|HFM1_uc010osv.1_Missense_Mutation_p.I913V	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1229							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AATTCAGATATGTTTAAATAT	0.284													C	91739356	C	C	91739356	3	2	257	1	0	0	0	0	1	0	0	0	7083	1464	51	4	646	4	HFM1	1	91739356	Missense_Mutation	SNP	T	TCGA-76-4925-01A-01D-1486-08	6247700	91739356	157511265	5	18395											
DPYD	1806	broad.mit.edu	37	chr1	97847978	97847978	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cttggcaagttccgtccagtCatttttattgtaactgcaca	7	10	1	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr1:97847978C>A	uc001drv.2	-	15	2082	c.1945G>T	c.(1945-1947)GAC>TAC	p.D649Y		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	649					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TCCGTCCAGTCATTTTTATTG	0.279													A	97847978	A	A	97847978	3	1	257	1	0	0	0	0	1	0	0	0	4745	826	29	5	1168	5	DPYD	1	97847978	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	6108622	97847978	151402643	6	18396											
RORC	6097	broad.mit.edu	37	chr1	151787517	151787517	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cctcaaaacgaagtccacatCggtcaggggtcagctggctg	12	12	3	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr1:151787517C>T	uc001ezh.2	-	5	791	c.683G>A	c.(682-684)CGA>CAA	p.R228Q	RORC_uc001ezg.2_Missense_Mutation_p.R207Q|RORC_uc010pdo.1_Missense_Mutation_p.R282Q|RORC_uc010pdp.1_Missense_Mutation_p.R228Q	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	228	Hinge (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AAGTCCACATCGGTCAGGGGT	0.612													T	151787517	T	T	151787517	3	4	257	1	0	0	0	0	1	0	0	0	13530	884	31	2	901	2	RORC	1	151787517	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	53939539	151787517	97463104	7	18397											
NTRK1	4914	broad.mit.edu	37	chr1	156849919	156849919	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagatcttcacctacggcaaGcagccctggtaccagctctc	9	15	3	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr1:156849919G>A	uc001fqh.1	+	16	2231	c.2175G>A	c.(2173-2175)AAG>AAA	p.K725K	NTRK1_uc001fqf.1_Silent_p.K689K|NTRK1_uc009wsi.1_Silent_p.K424K|NTRK1_uc001fqi.1_Silent_p.K719K|NTRK1_uc009wsk.1_Silent_p.K722K	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	725	Cytoplasmic (Potential).|Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CCTACGGCAAGCAGCCCTGGT	0.632			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			A	156849919	A	A	156849919	2	1	257	1	0	0	0	0	0	0	0	1	10706	962	34	3		3	NTRK1	1	156849919	Silent	SNP	G	TCGA-76-4925-01A-01D-1486-08	5062402	156849919	92400702	8	18398											
DEDD	9191	broad.mit.edu	37	chr1	161094314	161094314	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcagctgcaatccccaccGtactgaaagggcagggaaag	12	12	0	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr1:161094314G>A	uc001fxz.2	-	3	112	c.-61C>T	c.(-63--59)TACGG>TATGG		NIT1_uc001fxw.2_3'UTR|DEDD_uc009wty.2_Translation_Start_Site|DEDD_uc001fya.2_Translation_Start_Site|DEDD_uc001fyb.2_Translation_Start_Site|DEDD_uc010pkb.1_Translation_Start_Site|DEDD_uc001fyc.2_Intron	NM_001039712	NP_001034801	O75618	DEDD_HUMAN	death effector domain-containing protein						apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding				0	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			AATCCCCACCGTACTGAAAGG	0.388													A	161094314	A	A	161094314	1	1	257	1	0	0	0	0	0	0	0	0	4384	1160	40	1		1	DEDD	1	161094314	Translation_Start_Site	SNP	G	TCGA-76-4925-01A-01D-1486-08	4244395	161094314	88156307	9	18399											
SUCLG1	8802	broad.mit.edu	37	chr2	84676841	84676841	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atagagatgttgccgagaagCtgtgtaggaacaatgccgaa	13	6	0	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr2:84676841C>T	uc002son.2	-	2	326	c.133G>A	c.(133-135)GCT>ACT	p.A45T	SUCLG1_uc010ysk.1_Missense_Mutation_p.A32T	NM_003849	NP_003840	P53597	SUCA_HUMAN	succinate-CoA ligase, GDP-forming alpha subunit	45					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)	TGCCGAGAAGCTGTGTAGGAA	0.299													T	84676841	T	T	84676841	3	4	257	1	0	0	0	0	1	0	0	0	15363	797	28	3	939	3	SUCLG1	2	84676841	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		84676841	158522532	10	18400											
C2orf55	343990	broad.mit.edu	37	chr2	99412664	99412664	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccctgcttccggtccacagCgggcttcacaggggttatca	11	15	2	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr2:99412664C>T	uc002szf.1	-	9	2962	c.2668G>A	c.(2668-2670)GCT>ACT	p.A890T		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	890											0						CGGTCCACAGCGGGCTTCACA	0.498													T	99412664	T	T	99412664	3	4	257	1	0	0	0	0	1	0	0	0	2176	768	27	1	228	1	C2orf55	2	99412664	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	14735823	99412664	143786709	11	18401											
PCDP1	200373	broad.mit.edu	37	chr2	120362804	120362805	+	Frame_Shift_Ins	INS	-	CACT	CACT													aacgagacagatgaaggaggINScactctttgaacagaaagtc							TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr2:120362804_120362805insCACT	uc002tmb.2	+	12	1306_1307	c.214_215insCACT	c.(214-216)GCAfs	p.A72fs	PCDP1_uc010yyq.1_Frame_Shift_Ins_p.A202fs	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	358						cilium	calmodulin binding				0	Colorectal(110;0.196)					GATGAAGGAGGCACTCTTTGAA	0.386													CACT	120362805	CACT	CACT	120362804	7	5	257	1	0	1	1	0	0	0	0	0	11572	1203	42	0	224	0	PCDP1	2	120362804	Frame_Shift_Ins	INS	-	TCGA-76-4925-01A-01D-1486-08	20950140	120362804	122836569	12	18402											
THSD7B	80731	broad.mit.edu	37	chr2	137928455	137928455	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gatctgtttccctgatcatgGaaaatgtggcctgggacatc	11	9	2	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr2:137928455G>T	uc002tva.1	+	6	1577	c.1577G>T	c.(1576-1578)GGA>GTA	p.G526V	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.G416V	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTGATCATGGAAAATGTGGC	0.522													T	137928455	T	T	137928455	3	4	257	1	0	0	0	0	1	0	0	0	15877	1174	41	5	1599	5	THSD7B	2	137928455	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08	17565651	137928455	105270918	13	18403											
ADAMTS9	56999	broad.mit.edu	37	chr3	64527058	64527058	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accagtgtcacgtactctttGgggtggtcagagtgcatccc	12	11	3	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr3:64527058G>A	uc003dmg.2	-	35	5357	c.5325C>T	c.(5323-5325)CCC>CCT	p.P1775P	ADAMTS9_uc011bfo.1_Silent_p.P1747P|ADAMTS9_uc011bfp.1_Silent_p.P686P	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1775	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CGTACTCTTTGGGGTGGTCAG	0.502													A	64527058	A	A	64527058	2	1	257	1	0	0	0	0	0	0	0	1	273	1335	47	3		3	ADAMTS9	3	64527058	Silent	SNP	G	TCGA-76-4925-01A-01D-1486-08		64527058	133495372	14	18404											
CNTN3	5067	broad.mit.edu	37	chr3	74334529	74334529	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgttgtaagcccggacagcCgtgtaataggccaggttgct	13	10	0	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr3:74334529C>T	uc003dpm.1	-	19	2711	c.2631G>A	c.(2629-2631)ACG>ACA	p.T877T		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	877	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CCCGGACAGCCGTGTAATAGG	0.498													T	74334529	T	T	74334529	2	4	257	1	0	0	0	0	0	0	0	1	3642	639	23	2		2	CNTN3	3	74334529	Silent	SNP	C	TCGA-76-4925-01A-01D-1486-08	9807471	74334529	123687901	15	18405											
POPDC2	64091	broad.mit.edu	37	chr3	119373376	119373376	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacaccccctcctcagaaggCtgtagtgattcccactcagg	8	15	2	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr3:119373376C>T	uc003ecx.1	-	2	710	c.576G>A	c.(574-576)CAG>CAA	p.Q192Q	POPDC2_uc010hqw.1_Silent_p.Q192Q|POPDC2_uc003ecy.1_Silent_p.Q10Q	NM_022135	NP_071418	Q9HBU9	POPD2_HUMAN	popeye protein 2	192						integral to membrane				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.242)		CCTCAGAAGGCTGTAGTGATT	0.562													T	119373376	T	T	119373376	2	4	257	1	0	0	0	0	0	0	0	1	12255	796	28	3		3	POPDC2	3	119373376	Silent	SNP	C	TCGA-76-4925-01A-01D-1486-08	45038847	119373376	78649054	16	18406											
COPG	22820	broad.mit.edu	37	chr3	128982760	128982760	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catttaggtggtggttgtccAggccatcagtgccctgtgtc	13	10	1	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr3:128982760A>G	uc003els.2	+	13	1242	c.1142A>G	c.(1141-1143)CAG>CGG	p.Q381R	COPG_uc010htb.2_Missense_Mutation_p.Q287R	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	381	HEAT 4.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						GTGGTTGTCCAGGCCATCAGT	0.537													G	128982760	G	G	128982760	3	3	257	1	0	0	0	0	1	0	0	0	3731	188	7	4	1192	4	COPG	3	128982760	Missense_Mutation	SNP	A	TCGA-76-4925-01A-01D-1486-08	9609384	128982760	69039670	17	18407											
ZIC1	7545	broad.mit.edu	37	chr3	147128086	147128086	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcttcggccggccagacgGccttcacgtcgcaggcgcca	14	16	1	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr3:147128086G>A	uc003ewe.2	+	1	906	c.187G>A	c.(187-189)GCC>ACC	p.A63T		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	63					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CGGCCAGACGGCCTTCACGTC	0.687													A	147128086	A	A	147128086	3	1	257	1	0	0	0	0	1	0	0	0	17675	1203	42	3	189	3	ZIC1	3	147128086	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08	18145326	147128086	50894344	18	18408											
MED12L	116931	broad.mit.edu	37	chr3	150906259	150906259	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttttagatacacaggcccCctctttgtgtaagtagagaa	9	8	1	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr3:150906259C>T	uc003eyp.2	+	12	1783	c.1745C>T	c.(1744-1746)CCC>CTC	p.P582L	MED12L_uc011bnz.1_Missense_Mutation_p.P442L|MED12L_uc003eyn.2_Missense_Mutation_p.P582L|MED12L_uc003eyo.2_Missense_Mutation_p.P582L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	582					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACACAGGCCCCCTCTTTGTGT	0.343													T	150906259	T	T	150906259	3	4	257	1	0	0	0	0	1	0	0	0	9429	623	22	3	1791	3	MED12L	3	150906259	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	3778173	150906259	47116171	19	18409											
MAPKSP1	8649	broad.mit.edu	37	chr4	100805284	100805284	+	Splice_Site	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aacgattaaattgaaccaccTaaaaagaaaataagagccaa	5	7	0	3			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr4:100805284T>G	uc003hvg.2	-	6	487	c.238_splice	c.e6-1	p.V80_splice	MAPKSP1_uc003hvi.2_Splice_Site|MAPKSP1_uc003hvh.2_Splice_Site_p.V73_splice	NM_021970	NP_068805	Q9UHA4	LTOR3_HUMAN	MAPK scaffold protein 1						cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	Ragulator complex	protein binding				0						TTGAACCACCTAAAAAGAAAA	0.308													G	100805284	G	G	100805284	5	3	257	1	0	0	0	0	0	0	1	0	9293	1536	53	5	146	5	MAPKSP1	4	100805284	Splice_Site	SNP	T	TCGA-76-4925-01A-01D-1486-08		100805284	90348992	20	18410											
MTMR12	54545	broad.mit.edu	37	chr5	32255876	32255876	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aacaaagtatgctggcaatcTagaagaaagaaatgtcatca	8	6	3	3			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr5:32255876T>C	uc003jhq.2	-	8	884	c.714_splice	c.e8-1	p.R238_splice	MTMR12_uc010iuk.2_Splice_Site_p.R238_splice|MTMR12_uc010iul.2_Splice_Site_p.R238_splice	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12							cytoplasm	phosphatase activity			ovary(1)	1						GCTGGCAATCTAGAAGAAAGA	0.418													C	32255876	C	C	32255876	5	2	257	1	0	0	0	0	0	0	1	0	9941	1536	53	4	1567	4	MTMR12	5	32255876	Splice_Site	SNP	T	TCGA-76-4925-01A-01D-1486-08		32255876	148659384	21	18411											
SLCO6A1	133482	broad.mit.edu	37	chr5	101815988	101815988	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aagctacaaaccatattactTtttttctgtctccatagaat	3	9	2	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr5:101815988T>A	uc003knn.2	-	2	681	c.509A>T	c.(508-510)AAA>ATA	p.K170I	SLCO6A1_uc003kno.2_Missense_Mutation_p.K170I|SLCO6A1_uc003knp.2_Missense_Mutation_p.K170I|SLCO6A1_uc003knq.2_Missense_Mutation_p.K170I	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	170	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CCATATTACTTTTTTTCTGTC	0.333													A	101815988	A	A	101815988	3	1	257	1	0	0	0	0	1	0	0	0	14732	1841	64	5	1698	5	SLCO6A1	5	101815988	Missense_Mutation	SNP	T	TCGA-76-4925-01A-01D-1486-08	69560112	101815988	79099272	22	18412											
TRPC7	57113	broad.mit.edu	37	chr5	135692995	135692995	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaacatgtaggcgggaccCcggatggcctggcgacggcc	16	12	0	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr5:135692995C>T	uc003lbn.1	-	1	81	c.78G>A	c.(76-78)CGG>CGA	p.R26R	TRPC7_uc010jef.1_Silent_p.R18R|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Silent_p.R18R|TRPC7_uc010jei.1_Silent_p.R18R|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	27	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGGCGGGACCCCGGATGGCCT	0.612													T	135692995	T	T	135692995	2	4	257	1	0	0	0	0	0	0	0	1	16581	610	22	3		3	TRPC7	5	135692995	Silent	SNP	C	TCGA-76-4925-01A-01D-1486-08	33877007	135692995	45222265	23	18413											
PCDHA3	56145	broad.mit.edu	37	chr5	140182972	140182972	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgcgccgccaaccgaaggCgactgtgggccgggcaagcc	15	16	0	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr5:140182972C>T	uc003lhf.2	+	1	2190	c.2190C>T	c.(2188-2190)GGC>GGT	p.G730G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.G730G	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	730	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACCGAAGGCGACTGTGGGC	0.642													T	140182972	T	T	140182972	2	4	257	1	0	0	0	0	0	0	0	1	11525	755	27	1		1	PCDHA3	5	140182972	Silent	SNP	C	TCGA-76-4925-01A-01D-1486-08	4489977	140182972	40732288	24	18414											
ZFP57	346171	broad.mit.edu	37	chr6	29641071	29641071	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cttctggtggcgtttgagctCagactggtcccggaagctct	13	11	3	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr6:29641071C>G	uc011dlw.1	-	4	968	c.817G>C	c.(817-819)GAG>CAG	p.E273Q	ZFP57_uc003nnl.3_Missense_Mutation_p.E253Q	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	189	C2H2-type 4.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CGTTTGAGCTCAGACTGGTCC	0.552													G	29641071	G	G	29641071	3	3	257	1	0	0	0	0	1	0	0	0	17648	835	29	5	797	5	ZFP57	6	29641071	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		29641071	141473996	25	18415											
C6orf127	340204	broad.mit.edu	37	chr6	35754859	35754859	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaattgcgagtcgcactgcGcggagaaggggtccgagggc	17	10	0	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr6:35754859G>A	uc003old.3	+	2	241	c.184G>A	c.(184-186)GCG>ACG	p.A62T		NM_001010886	NP_001010886	A2RUU4	CF127_HUMAN	hypothetical protein LOC340204 precursor	62					digestion|lipid catabolic process	extracellular region	enzyme activator activity			skin(1)	1						GTCGCACTGCGCGGAGAAGGG	0.662													A	35754859	A	A	35754859	3	1	257	1	0	0	0	0	1	0	0	0	2327	1087	38	1	190	1	C6orf127	6	35754859	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08	6113788	35754859	135360208	26	18416											
STXBP5	134957	broad.mit.edu	37	chr6	147704054	147704054	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggctggcactagatgaaagaGggcagaaacttggcgatctg	15	7	1	4			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr6:147704054G>C	uc003qlz.2	+	27	3495	c.3334G>C	c.(3334-3336)GGG>CGG	p.G1112R	STXBP5_uc010khz.1_Missense_Mutation_p.G1076R|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.G767R	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	1112	v-SNARE coiled-coil homology.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		AGATGAAAGAGGGCAGAAACT	0.483													C	147704054	C	C	147704054	3	2	257	1	0	0	0	0	1	0	0	0	15355	1000	35	5	3440	5	STXBP5	6	147704054	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08	111949195	147704054	23411013	27	18417											
NDUFA4	4697	broad.mit.edu	37	chr7	10979661	10979661	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	acgctcggatgcttcttggcCtgaccgatgatctggcggag	14	11	2	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:10979661C>G	uc003srx.1	-	1	153	c.24G>C	c.(22-24)CAG>CAC	p.Q8H		NM_002489	NP_002480	O00483	NDUA4_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	8					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)	NADH(DB00157)	GCTTCTTGGCCTGACCGATGA	0.547													G	10979661	G	G	10979661	3	3	257	1	0	0	0	0	1	0	0	0	10266	680	24	5	237	5	NDUFA4	7	10979661	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		10979661	148159002	28	18418											
DNAH11	8701	broad.mit.edu	37	chr7	21611464	21611464	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggaatttgaaaagctggaaaGactggaatttggtggtacca	13	4	0	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:21611464G>A	uc003svc.2	+	8	1497	c.1466G>A	c.(1465-1467)AGA>AAA	p.R489K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	489	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AAGCTGGAAAGACTGGAATTT	0.353									Kartagener_syndrome				A	21611464	A	A	21611464	3	1	257	1	0	0	0	0	1	0	0	0	4599	942	33	3	1496	3	DNAH11	7	21611464	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08	10631803	21611464	137527199	29	18419											
CHN2	1124	broad.mit.edu	37	chr7	29539565	29539565	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaagaggatcaagaaagtGtactgttgtgacctcacaac	9	9	3	3			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:29539565G>A	uc003szz.2	+	9	1259	c.822G>A	c.(820-822)GTG>GTA	p.V274V	CHN2_uc011jzs.1_Silent_p.V349V|CHN2_uc010kva.2_Silent_p.V44V|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Silent_p.V239V|CHN2_uc011jzt.1_Silent_p.V287V|CHN2_uc010kvd.2_Silent_p.V130V|CHN2_uc011jzu.1_Silent_p.V259V|CHN2_uc010kvg.2_Silent_p.V138V|CHN2_uc010kvh.2_Intron|CHN2_uc010kvi.2_Silent_p.V138V|CHN2_uc010kve.2_Silent_p.V138V|CHN2_uc003taa.2_Silent_p.V138V|CHN2_uc010kvf.2_Intron|CHN2_uc010kvj.2_Silent_p.V93V|CHN2_uc010kvk.2_Intron|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Silent_p.V93V|CHN2_uc011jzv.1_Silent_p.V67V	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	274					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						TCAAGAAAGTGTACTGTTGTG	0.448													A	29539565	A	A	29539565	2	1	257	1	0	0	0	0	0	0	0	1	3363	1364	48	3		3	CHN2	7	29539565	Silent	SNP	G	TCGA-76-4925-01A-01D-1486-08	7928101	29539565	129599098	30	18420											
ELN	2006	broad.mit.edu	37	chr7	73472022	73472022	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagccgccaaagccgcccaGtttggtaagtccccctcacc	9	18	1	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:73472022G>A	uc003tzw.2	+	22	1501	c.1410G>A	c.(1408-1410)CAG>CAA	p.Q470Q	RFC2_uc011kfa.1_Intron|ELN_uc011kfe.1_Silent_p.Q439Q|ELN_uc003tzn.2_Silent_p.Q470Q|ELN_uc003tzz.2_Intron|ELN_uc003tzo.2_Intron|ELN_uc003tzp.2_Intron|ELN_uc003tzq.2_Intron|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Intron|ELN_uc003tzt.2_Silent_p.Q475Q|ELN_uc003tzu.2_Intron|ELN_uc003tzv.2_Intron|ELN_uc003tzx.2_Silent_p.Q460Q|ELN_uc011kff.1_Silent_p.Q470Q|ELN_uc003tzy.2_Intron	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	499	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	AAGCCGCCCAGTTTGGTAAGT	0.612			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						A	73472022	A	A	73472022	2	1	257	1	0	0	0	0	0	0	0	1	5071	1020	36	3		3	ELN	7	73472022	Silent	SNP	G	TCGA-76-4925-01A-01D-1486-08	43932457	73472022	85666641	31	18421											
GNAT3	346562	broad.mit.edu	37	chr7	80091548	80091548	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	aagatatcttttttgttgagGaacaggacaatggaggttgt	12	3	1	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:80091548G>C	uc011kgu.1	-	7	801	c.801C>G	c.(799-801)TTC>TTG	p.F267L	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	267					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TTTTGTTGAGGAACAGGACAA	0.343													C	80091548	C	C	80091548	3	2	257	1	0	0	0	0	1	0	0	0	6513	1165	41	5	269	5	GNAT3	7	80091548	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08	6619526	80091548	79047115	32	18422											
CALCR	799	broad.mit.edu	37	chr7	93091387	93091387	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttacttacaatgccttcctaTatttccaattcaaaggaaaa	3	9	1	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:93091387T>C	uc003umv.1	-	8	872	c.611A>G	c.(610-612)TAT>TGT	p.Y204C	CALCR_uc011kia.1_5'Flank|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_Intron|CALCR_uc003umu.1_Intron|CALCR_uc003umw.2_Intron	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	186	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TGCCTTCCTATATTTCCAATT	0.284													C	93091387	C	C	93091387	3	2	257	1	0	0	0	0	1	0	0	0	2579	1406	49	4	947	4	CALCR	7	93091387	Missense_Mutation	SNP	T	TCGA-76-4925-01A-01D-1486-08	12999839	93091387	66047276	33	18423											
GRM8	2918	broad.mit.edu	37	chr7	126882860	126882860	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgggtggatctccattagcAcacttcacatccgaagcatc	8	12	2	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:126882860A>G	uc003vlr.2	-	1	710	c.399T>C	c.(397-399)TGT>TGC	p.C133C	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.C133C|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	133	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CTCCATTAGCACACTTCACAT	0.483										HNSCC(24;0.065)			G	126882860	G	G	126882860	2	3	257	1	0	0	0	0	0	0	0	1	6803	157	6	4		4	GRM8	7	126882860	Silent	SNP	A	TCGA-76-4925-01A-01D-1486-08	33791473	126882860	32255803	34	18424											
TSGA13	114960	broad.mit.edu	37	chr7	130357671	130357671	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttttttctgaggcatgcGgggcagccagaggttctcag	13	9	2	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:130357671G>A	uc003vqi.2	-	6	890	c.433C>T	c.(433-435)CGC>TGC	p.R145C	TSGA13_uc003vqj.2_Missense_Mutation_p.R145C	NM_052933	NP_443165	Q96PP4	TSG13_HUMAN	testis specific, 13	145										ovary(2)	2	Melanoma(18;0.0435)					TGAGGCATGCGGGGCAGCCAG	0.473													A	130357671	A	A	130357671	3	1	257	1	0	0	0	0	1	0	0	0	16616	1116	39	2	406	2	TSGA13	7	130357671	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08	3474811	130357671	28780992	35	18425											
TRPV5	56302	broad.mit.edu	37	chr7	142625188	142625188	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccttggcatccatacctctcGtttatcagaggagaccacaa	7	13	2	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:142625188G>A	uc003wby.1	-	7	1168	c.904C>T	c.(904-906)CGA>TGA	p.R302*	TRPV5_uc003wbz.2_Nonsense_Mutation_p.R302*	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	302	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity	p.R302R(1)		ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CATACCTCTCGTTTATCAGAG	0.527													A	142625188	A	A	142625188	4	1	257	1	0	0	0	0	0	1	0	0	16596	1153	40	1	1321	1	TRPV5	7	142625188	Nonsense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08	12267517	142625188	16513475	36	18426											
MLL3	58508	broad.mit.edu	37	chr7	151944990	151944990	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cattaaaatcaccctacctgTttggaccgaggtctaccagg	8	12	2	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr7:151944990T>C	uc003wla.2	-	14	2748	c.2529A>G	c.(2527-2529)AAA>AAG	p.K843K		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	843					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACCCTACCTGTTTGGACCGAG	0.368			N		medulloblastoma								C	151944990	C	C	151944990	2	2	257	1	0	0	0	0	0	0	0	1	9622	1722	60	4		4	MLL3	7	151944990	Silent	SNP	T	TCGA-76-4925-01A-01D-1486-08	9319802	151944990	7193673	37	18427											
EIF3H	8667	broad.mit.edu	37	chr8	117738327	117738327	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtaatttcaagccgatcttCtacaaccagacccaaaagca	6	12	3	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr8:117738327C>T	uc003yoa.2	-	2	243	c.217G>A	c.(217-219)GAA>AAA	p.E73K	EIF3H_uc003yob.2_Missense_Mutation_p.E87K|EIF3H_uc011lhz.1_Missense_Mutation_p.E73K	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	73	MPN.			E -> K (in Ref. 2; AAC84044).	regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					AGCCGATCTTCTACAACCAGA	0.403													T	117738327	T	T	117738327	3	4	257	1	0	0	0	0	1	0	0	0	5018	922	32	3	869	3	EIF3H	8	117738327	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		117738327	28625695	38	18428											
FAM83H	286077	broad.mit.edu	37	chr8	144808899	144808899	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggcaccggactacccctgCgctcggggtaggctgaggtg	18	12	0	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr8:144808899C>T	uc003yzk.2	-	5	2801	c.2732G>A	c.(2731-2733)CGC>CAC	p.R911H	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	911					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			ACTACCCCTGCGCTCGGGGTA	0.682													T	144808899	T	T	144808899	3	4	257	1	0	0	0	0	1	0	0	0	5640	768	27	1	811	1	FAM83H	8	144808899	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	27070572	144808899	1555123	39	18429											
DENND4C	55667	broad.mit.edu	37	chr9	19305352	19305352	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttaaaactttttccccagatGatctttccatttcagtggca	5	10	2	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr9:19305352G>A	uc003znq.2	+	6	639	c.606G>A	c.(604-606)ATG>ATA	p.M202I	DENND4C_uc011lnc.1_5'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	202	DENN.|Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2						TTCCCCAGATGATCTTTCCAT	0.343													A	19305352	A	A	19305352	3	1	257	1	0	0	0	0	1	0	0	0	4435	1290	45	3	628	3	DENND4C	9	19305352	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08		19305352	121908079	40	18430											
CYLC2	1539	broad.mit.edu	37	chr9	105763888	105763888	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	taaactttgggccatatgatAattacattccaggtaagaaa	7	6	0	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr9:105763888A>T	uc004bbs.2	+	2	116	c.46A>T	c.(46-48)AAT>TAT	p.N16Y		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	16					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				GCCATATGATAATTACATTCC	0.259													T	105763888	T	T	105763888	3	4	257	1	0	0	0	0	1	0	0	0	4142	362	13	5	52	5	CYLC2	9	105763888	Missense_Mutation	SNP	A	TCGA-76-4925-01A-01D-1486-08	86458536	105763888	35449543	41	18431											
C9orf84	158401	broad.mit.edu	37	chr9	114466161	114466161	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tattttctacctagttttacCtgcaaaattatggcagtgtg	7	7	1	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr9:114466161C>A	uc004bfr.2	-	20	2910	c.2775G>T	c.(2773-2775)CAG>CAT	p.Q925H	C9orf84_uc011lwt.1_Intron|C9orf84_uc004bfq.2_Missense_Mutation_p.Q886H|C9orf84_uc010mug.2_Missense_Mutation_p.Q836H	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	925										ovary(2)	2						CTAGTTTTACCTGCAAAATTA	0.318													A	114466161	A	A	114466161	3	1	257	1	0	0	0	0	1	0	0	0	2500	695	24	5	1587	5	C9orf84	9	114466161	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	8702273	114466161	26747270	42	18432											
ENG	2022	broad.mit.edu	37	chr9	130605418	130605418	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggacttcaaggatggcattGggggcctgagccacgcagcc	15	11	1	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr9:130605418G>A	uc004bsj.3	-	2	587	c.174C>T	c.(172-174)CCC>CCT	p.P58P	ENG_uc011mam.1_5'UTR|ENG_uc004bsk.3_Silent_p.P58P	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	58	Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						GGATGGCATTGGGGGCCTGAG	0.602									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				A	130605418	A	A	130605418	2	1	257	1	0	0	0	0	0	0	0	1	5117	1335	47	3		3	ENG	9	130605418	Silent	SNP	G	TCGA-76-4925-01A-01D-1486-08	16139257	130605418	10608013	43	18433											
MMRN2	79812	broad.mit.edu	37	chr10	88703548	88703548	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaatttggtgtccacatcGgcttggagctctgagatcga	11	9	2	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr10:88703548G>A	uc001kea.2	-	6	1120	c.993C>T	c.(991-993)GCC>GCT	p.A331A	MMRN2_uc010qmn.1_Intron|MMRN2_uc009xtb.2_Silent_p.A288A	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	331	Potential.					extracellular space				large_intestine(1)	1						TGTCCACATCGGCTTGGAGCT	0.622													A	88703548	A	A	88703548	2	1	257	1	0	0	0	0	0	0	0	1	9671	1103	39	2		2	MMRN2	10	88703548	Silent	SNP	G	TCGA-76-4925-01A-01D-1486-08		88703548	46831199	44	18434											
PTEN	5728	broad.mit.edu	37	chr10	89717715	89717716	+	Frame_Shift_Ins	INS	-	A	A													tttgagttccctcagccgttINSacctgtgtgtggtgatatca							TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr10:89717715_89717716insA	uc001kfb.2	+	8	1771_1772	c.740_741insA	c.(739-741)TTAfs	p.L247fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	247	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.P248fs*5(11)|p.R55fs*1(4)|p.L247*(3)|p.L247fs*10(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.L247fs*11(1)|p.L247fs*12(1)|p.G165_*404del(1)|p.L247fs*6(1)|p.L247fs*4(1)|p.?(1)|p.L247fs*5(1)|p.G165_K342del(1)|p.L247fs*8(1)|p.P246_L247insGP(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CCTCAGCCGTTACCTGTGTGTG	0.406		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89717716	A	A	89717715	7	5	257	1	0	1	1	0	0	0	0	0	12738	1764	61	0	766	0	PTEN	10	89717715	Frame_Shift_Ins	INS	-	TCGA-76-4925-01A-01D-1486-08	1014167	89717715	45817032	45	18435											
ART1	417	broad.mit.edu	37	chr11	3681258	3681258	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcctgggcagcggccagcGtccaccccggtgccaccagg	14	18	0	0	rs141732093		TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:3681258G>A	uc001lye.1	+	3	610	c.509G>A	c.(508-510)CGT>CAT	p.R170H	ART1_uc009yeb.1_Missense_Mutation_p.R170H	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	170					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	AGCGGCCAGCGTCCACCCCGG	0.701													A	3681258	A	A	3681258	3	1	257	1	0	0	0	0	1	0	0	0	997	1145	40	1	515	1	ART1	11	3681258	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08		3681258	131325258	46	18436											
OR10A3	26496	broad.mit.edu	37	chr11	7960954	7960954	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgatggcatttcccatcagGgtcaccacataaataactag	7	10	2	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:7960954G>A	uc010rbi.1	-	1	114	c.114C>T	c.(112-114)ACC>ACT	p.T38T		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	38	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTCCCATCAGGGTCACCACAT	0.473													A	7960954	A	A	7960954	2	1	257	1	0	0	0	0	0	0	0	1	10891	1219	43	3		3	OR10A3	11	7960954	Silent	SNP	G	TCGA-76-4925-01A-01D-1486-08	4279696	7960954	127045562	47	18437											
CALCA	796	broad.mit.edu	37	chr11	14991572	14991572	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	agccagcaggaggcgcgcttCgtcctcactgagcgtggccg	15	14	1	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:14991572C>T	uc001mlt.1	-	3	211	c.136G>A	c.(136-138)GAA>AAA	p.E46K	CALCA_uc001mlu.1_RNA|CALCA_uc001mlv.1_Missense_Mutation_p.E46K|CALCA_uc001mlw.1_Missense_Mutation_p.E46K	NM_001033953	NP_001029125	P06881	CALCA_HUMAN	calcitonin isoform CGRP preproprotein	46					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)	1					Phentolamine(DB00692)	AGGCGCGCTTCGTCCTCACTG	0.642											OREG0020791	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	14991572	T	T	14991572	3	4	257	1	0	0	0	0	1	0	0	0	2575	893	31	2	461	2	CALCA	11	14991572	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	7030618	14991572	120014944	48	18438											
SYT13	57586	broad.mit.edu	37	chr11	45274024	45274024	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcccctagaggcacagatGtcccgtccaggcccaggcgg	13	16	0	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:45274024G>A	uc001myq.2	-	4	920	c.794C>T	c.(793-795)ACA>ATA	p.T265I	SYT13_uc009yku.1_Missense_Mutation_p.T121I	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	265	Cytoplasmic (Potential).					transport vesicle				ovary(1)	1						AGGCACAGATGTCCCGTCCAG	0.647											OREG0020928	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	45274024	A	A	45274024	3	1	257	1	0	0	0	0	1	0	0	0	15466	1377	48	3	498	3	SYT13	11	45274024	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08	30282452	45274024	89732492	49	18439											
OR8K3	219473	broad.mit.edu	37	chr11	56086116	56086116	+	Frame_Shift_Del	DEL	C	-	-													ttgtgttcattggtagtgaaCtttttattctctcagccatg							TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:56086116delC	uc010rjf.1	+	1	334	c.334delC	c.(334-336)CTTfs	p.L112fs		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TGGTAGTGAACTTTTTATTCT	0.378													-	56086116	-	-	56086116	7	5	257	1	0	1	0	1	0	0	0	0	11244	565	20	0	336	0	OR8K3	11	56086116	Frame_Shift_Del	DEL	C	TCGA-76-4925-01A-01D-1486-08	10812092	56086116	78920400	50	18440											
TCN1	6947	broad.mit.edu	37	chr11	59629066	59629066	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagtggttgacaacttcggCggttgagtagttcccattga	13	7	0	3	rs77116206	by1000genomes	TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:59629066C>T	uc001noj.2	-	4	588	c.490G>A	c.(490-492)GCC>ACC	p.A164T		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	164					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACAACTTCGGCGGTTGAGTAG	0.453													T	59629066	T	T	59629066	3	4	257	1	0	0	0	0	1	0	0	0	15703	768	27	1	835	1	TCN1	11	59629066	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	3542950	59629066	75377450	51	18441											
MTA2	9219	broad.mit.edu	37	chr11	62364206	62364206	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accattcctccatctcatccCgacacagcaccgggcctccc	5	21	1	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:62364206C>T	uc001ntq.1	-	9	1166	c.785G>A	c.(784-786)CGG>CAG	p.R262Q	MTA2_uc010rlx.1_Missense_Mutation_p.R89Q	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	262					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CATCTCATCCCGACACAGCAC	0.542													T	62364206	T	T	62364206	3	4	257	1	0	0	0	0	1	0	0	0	9909	652	23	2	1261	2	MTA2	11	62364206	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	2735140	62364206	72642310	52	18442											
SF1	7536	broad.mit.edu	37	chr11	64537728	64537728	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaccgagcccctccgcttacTtgtaatctgcaggtggcttg	11	13	1	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:64537728T>C	uc001obb.1	-	4	766	c.389A>G	c.(388-390)AAA>AGA	p.K130R	SF1_uc010rnm.1_5'Flank|SF1_uc010rnn.1_Missense_Mutation_p.K104R|SF1_uc001oaz.1_Missense_Mutation_p.K255R|SF1_uc001oba.1_Missense_Mutation_p.K130R|SF1_uc001obc.1_Missense_Mutation_p.K130R|SF1_uc001obd.1_Missense_Mutation_p.K130R|SF1_uc001obe.1_Missense_Mutation_p.K15R|SF1_uc010rno.1_Missense_Mutation_p.K15R	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	130					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						CTCCGCTTACTTGTAATCTGC	0.532													C	64537728	C	C	64537728	3	2	257	1	0	0	0	0	1	0	0	0	14145	1623	56	4	1708	4	SF1	11	64537728	Missense_Mutation	SNP	T	TCGA-76-4925-01A-01D-1486-08	2173522	64537728	70468788	53	18443											
USP35	57558	broad.mit.edu	37	chr11	77921629	77921629	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcgaatctgtcagcaacgtcAcctccttcttccctaaggac	6	15	4	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:77921629A>C	uc009yva.1	+	10	2974	c.2728A>C	c.(2728-2730)ACC>CCC	p.T910P	USP35_uc001oze.2_Missense_Mutation_p.T666P|USP35_uc001ozc.2_Missense_Mutation_p.T478P|USP35_uc010rsp.1_Missense_Mutation_p.T342P|USP35_uc001ozd.2_Missense_Mutation_p.T521P|USP35_uc001ozf.2_Missense_Mutation_p.T641P	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	910					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CAGCAACGTCACCTCCTTCTT	0.572													C	77921629	C	C	77921629	3	2	257	1	0	0	0	0	1	0	0	0	17063	159	6	5	2762	5	USP35	11	77921629	Missense_Mutation	SNP	A	TCGA-76-4925-01A-01D-1486-08	13383901	77921629	57084887	54	18444											
MMP13	4322	broad.mit.edu	37	chr11	102822866	102822866	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtcaagacctaaggagtggCcgaactcatgcgcagcaaca	12	11	2	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr11:102822866C>T	uc001phl.2	-	5	702	c.674G>A	c.(673-675)GGC>GAC	p.G225D		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	225					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TAAGGAGTGGCCGAACTCATG	0.443													T	102822866	T	T	102822866	3	4	257	1	0	0	0	0	1	0	0	0	9652	739	26	3	765	3	MMP13	11	102822866	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	24901237	102822866	32183650	55	18445											
IQSEC3	440073	broad.mit.edu	37	chr12	247574	247574	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctggagagccgcctgccaCggcggatctccctgcgcaag	13	15	2	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr12:247574C>T	uc001qhw.1	+	1	142	c.136C>T	c.(136-138)CGG>TGG	p.R46W	IQSEC3_uc001qhu.1_Missense_Mutation_p.R46W|IQSEC3_uc001qht.1_Missense_Mutation_p.R131W|uc001qhv.1_RNA	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	349					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CCGCCTGCCACGGCGGATCTC	0.667													T	247574	T	T	247574	3	4	257	1	0	0	0	0	1	0	0	0	7819	527	19	1	1059	1	IQSEC3	12	247574	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		247574	133604321	56	18446											
CLEC4C	170482	broad.mit.edu	37	chr12	7898972	7898972	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actgaggagcaagatggataCgactgccatggaccagacct	12	10	0	3			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr12:7898972C>T	uc001qtg.1	-	2	253	c.79G>A	c.(79-81)GTA>ATA	p.V27I	CLEC4C_uc001qth.1_Missense_Mutation_p.V27I|CLEC4C_uc001qti.1_Intron	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	27	Helical; Signal-anchor for type II membrane protein; (Potential).				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		AAGATGGATACGACTGCCATG	0.483													T	7898972	T	T	7898972	3	4	257	1	0	0	0	0	1	0	0	0	3513	536	19	1	582	1	CLEC4C	12	7898972	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	7651398	7898972	125952923	57	18447											
C12orf51	283450	broad.mit.edu	37	chr12	112605619	112605619	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cctcccggcctctgcctaccTtgttcttattgacagctgag	8	15	2	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr12:112605619T>A	uc009zwc.2	-	64	11063	c.11045A>T	c.(11044-11046)AAG>ATG	p.K3682M		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TCTGCCTACCTTGTTCTTATT	0.617													A	112605619	A	A	112605619	3	1	257	1	0	0	0	0	1	0	0	0	1696	1623	56	5	969	5	C12orf51	12	112605619	Missense_Mutation	SNP	T	TCGA-76-4925-01A-01D-1486-08	104706647	112605619	21246276	58	18448											
POLE2	5427	broad.mit.edu	37	chr14	50120778	50120778	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attagtgatgctttcagcaaGtggtggcctataaaaacaat	9	6	1	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr14:50120778G>A	uc001wwu.2	-	15	1155	c.1141C>T	c.(1141-1143)CTT>TTT	p.L381F	SDCCAG1_uc010anj.1_Intron|POLE2_uc010ann.2_Missense_Mutation_p.L95F|POLE2_uc001wwv.2_RNA|POLE2_uc010ano.2_Missense_Mutation_p.L96F	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	381					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)					CTTTCAGCAAGTGGTGGCCTA	0.294													A	50120778	A	A	50120778	3	1	257	1	0	0	0	0	1	0	0	0	12197	1029	36	3	462	3	POLE2	14	50120778	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08		50120778	57228762	59	18449											
MYO9A	4649	broad.mit.edu	37	chr15	72195395	72195395	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagaagtacatggaagtggcTcacaaaatcctgaaaaataa	8	6	1	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr15:72195395T>C	uc002atl.3	-	22	3360	c.2887A>G	c.(2887-2889)AGC>GGC	p.S963G	MYO9A_uc010biq.2_Missense_Mutation_p.S583G|MYO9A_uc002atn.1_Missense_Mutation_p.S944G	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	963	Myosin head-like 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TGGAAGTGGCTCACAAAATCC	0.269													C	72195395	C	C	72195395	3	2	257	1	0	0	0	0	1	0	0	0	10084	1551	54	4	4843	4	MYO9A	15	72195395	Missense_Mutation	SNP	T	TCGA-76-4925-01A-01D-1486-08		72195395	30335997	60	18450											
IL16	3603	broad.mit.edu	37	chr15	81598457	81598457	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcccgacctcaactcctccaCtgactctgcagcctcagcct	6	20	3	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr15:81598457C>G	uc002bgh.3	+	17	4005	c.3629C>G	c.(3628-3630)ACT>AGT	p.T1210S	IL16_uc010blq.1_Missense_Mutation_p.T1164S|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.T1252S|IL16_uc002bgg.2_Missense_Mutation_p.T1210S|IL16_uc002bgi.1_Missense_Mutation_p.T600S|IL16_uc002bgj.2_Missense_Mutation_p.T704S|IL16_uc002bgk.2_Missense_Mutation_p.T509S|IL16_uc002bgl.1_Missense_Mutation_p.T509S|IL16_uc010unq.1_Missense_Mutation_p.T509S	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	1210					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						AACTCCTCCACTGACTCTGCA	0.562													G	81598457	G	G	81598457	3	3	257	1	0	0	0	0	1	0	0	0	7633	565	20	5	3691	5	IL16	15	81598457	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	9403062	81598457	20932935	61	18451											
HS3ST6	64711	broad.mit.edu	37	chr16	1961835	1961835	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccaggaagtcctgcacgCggccgacctctccggccggg	15	17	1	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr16:1961835C>T	uc002cnf.2	-	2	692	c.692G>A	c.(691-693)CGC>CAC	p.R231H		NM_001009606	NP_001009606	C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine)	231											0						GTCCTGCACGCGGCCGACCTC	0.667													T	1961835	T	T	1961835	3	4	257	1	0	0	0	0	1	0	0	0	7369	768	27	1	247	1	HS3ST6	16	1961835	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		1961835	88392918	62	18452											
CLUAP1	23059	broad.mit.edu	37	chr16	3554767	3554767	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gataccctcgacatatttctAtggaaaatttccgtacaccc	5	12	1	0			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr16:3554767A>G	uc002cvk.1	+	2	175	c.70A>G	c.(70-72)ATG>GTG	p.M24V	CLUAP1_uc002cvj.1_Missense_Mutation_p.M24V|CLUAP1_uc002cvl.1_Missense_Mutation_p.M24V	NM_015041	NP_055856	Q96AJ1	CLUA1_HUMAN	clusterin associated protein 1 isoform 1	24						nucleus	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ACATATTTCTATGGAAAATTT	0.408													G	3554767	G	G	3554767	3	3	257	1	0	0	0	0	1	0	0	0	3569	449	16	4	76	4	CLUAP1	16	3554767	Missense_Mutation	SNP	A	TCGA-76-4925-01A-01D-1486-08	1592932	3554767	86799986	63	18453											
PLCG2	5336	broad.mit.edu	37	chr16	81891938	81891938	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccaggaagcgatgaatgcGtccacgcccaccattatcga	9	14	0	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr16:81891938G>A	uc002fgt.2	+	4	560	c.408G>A	c.(406-408)GCG>GCA	p.A136A	PLCG2_uc010chg.1_Silent_p.A136A	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	136					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						CGATGAATGCGTCCACGCCCA	0.478													A	81891938	A	A	81891938	2	1	257	1	0	0	0	0	0	0	0	1	12036	1132	40	1		1	PLCG2	16	81891938	Silent	SNP	G	TCGA-76-4925-01A-01D-1486-08	78337171	81891938	8462815	64	18454											
TP53	7157	broad.mit.edu	37	chr17	7577535	7577535	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgatgatggtgaggatgggcCtccggttcatgccgcccatg	15	10	1	3			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr17:7577535C>G	uc002gim.2	-	7	940	c.746G>C	c.(745-747)AGG>ACG	p.R249T	TP53_uc002gig.1_Missense_Mutation_p.R249T|TP53_uc002gih.2_Missense_Mutation_p.R249T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R117T|TP53_uc010cng.1_Missense_Mutation_p.R117T|TP53_uc002gii.1_Missense_Mutation_p.R117T|TP53_uc010cnh.1_Missense_Mutation_p.R249T|TP53_uc010cni.1_Missense_Mutation_p.R249T|TP53_uc002gij.2_Missense_Mutation_p.R249T|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R156T|TP53_uc002gio.2_Missense_Mutation_p.R117T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	249	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> I (in a sporadic cancer; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249S(303)|p.R249M(25)|p.R249G(24)|p.R249W(23)|p.R249T(16)|p.R249K(14)|p.0?(7)|p.R249R(6)|p.R249fs*96(6)|p.M246_P250delMNRRP(2)|p.R249fs*14(2)|p.R248_P250delRRP(1)|p.R249_P250delRP(1)|p.R249_P250insR(1)|p.R249_P250>SS(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*19(1)|p.R249_T256delRPILTIIT(1)|p.R249fs*15(1)|p.R249_I251delRPI(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGATGGGCCTCCGGTTCAT	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			G	7577535	G	G	7577535	3	3	257	1	0	0	0	0	1	0	0	0	16378	681	24	5	544	5	TP53	17	7577535	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		7577535	73617675	65	18455											
DDX5	1655	broad.mit.edu	37	chr17	62500099	62500102	+	Splice_Site	DEL	ACAG	-	-													tcaagagttctcccaaacttAcagacaatgttttcccagat							TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr17:62500099_62500102delACAG	uc002jek.2	-	4	688	c.441_splice	c.e4+1	p.S147_splice	DDX5_uc010deh.2_Splice_Site_p.S147_splice|DDX5_uc002jej.2_Splice_Site_p.S42_splice|DDX5_uc010wqa.1_Intron|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5						cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			TCCCAAACTTACAGACAATGTTTT	0.397			T	ETV4	prostate								-	62500102	-	-	62500099	8	5	257	1	0	1	0	1	0	0	1	0	4367	405	14	0	1441	0	DDX5	17	62500099	Splice_Site	DEL	ACAG	TCGA-76-4925-01A-01D-1486-08	54922564	62500099	18695111	66	18456											
GATA6	2627	broad.mit.edu	37	chr18	19762767	19762767	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggaattcaaaccaggaaacGaaaacctaagaacataaata	7	7	1	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr18:19762767G>A	uc002ktt.1	+	5	1743	c.1478G>A	c.(1477-1479)CGA>CAA	p.R493Q	GATA6_uc002ktu.1_Missense_Mutation_p.R493Q	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	493					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			ACCAGGAAACGAAAACCTAAG	0.313													A	19762767	A	A	19762767	3	1	257	1	0	0	0	0	1	0	0	0	6258	1058	37	2	1492	2	GATA6	18	19762767	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08		19762767	58314481	67	18457											
CREB3L3	84699	broad.mit.edu	37	chr19	4168400	4168400	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaaaatccggaacaagcagtCggcgcaagaaagcaggaaga	13	8	0	2	rs147422200	by1000genomes	TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr19:4168400C>T	uc002lzl.2	+	6	883	c.767C>T	c.(766-768)TCG>TTG	p.S256L	CREB3L3_uc002lzm.2_Missense_Mutation_p.S246L|CREB3L3_uc010xib.1_Missense_Mutation_p.S245L|CREB3L3_uc010xic.1_Intron	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	256	Basic motif.|Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		AACAAGCAGTCGGCGCAAGAA	0.398													T	4168400	T	T	4168400	3	4	257	1	0	0	0	0	1	0	0	0	3858	893	31	2	789	2	CREB3L3	19	4168400	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		4168400	54960583	68	18458											
RAVER1	125950	broad.mit.edu	37	chr19	10434119	10434119	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccaggggcgcagaaggagaCtcgcaggtggctgcccccca	15	15	0	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr19:10434119C>T	uc002moa.2	-	4	1011	c.931G>A	c.(931-933)GTC>ATC	p.V311I		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	294	RRM 3.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CAGAAGGAGACTCGCAGGTGG	0.716													T	10434119	T	T	10434119	3	4	257	1	0	0	0	0	1	0	0	0	13094	565	20	3	1379	3	RAVER1	19	10434119	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	6265719	10434119	48694864	69	18459											
GATAD2A	54815	broad.mit.edu	37	chr19	19576172	19576172	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaatgaccgaagaagcatgCcgaacacggagtcagaaacg	12	9	1	4			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr19:19576172C>T	uc010xqt.1	+	2	330	c.18C>T	c.(16-18)TGC>TGT	p.C6C	GATAD2A_uc010xqu.1_5'UTR|GATAD2A_uc010xqv.1_Silent_p.C25C|GATAD2A_uc010xqw.1_5'UTR	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	6					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AAGAAGCATGCCGAACACGGA	0.473													T	19576172	T	T	19576172	2	4	257	1	0	0	0	0	0	0	0	1	6260	747	26	3		3	GATAD2A	19	19576172	Silent	SNP	C	TCGA-76-4925-01A-01D-1486-08	9142053	19576172	39552811	70	18460											
PLEKHG2	64857	broad.mit.edu	37	chr19	39908646	39908646	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggaggcggagggggtggcccCcggctacgagggggtgagcg	24	9	0	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr19:39908646C>G	uc010xuz.1	+	9	1309	c.984C>G	c.(982-984)CCC>CCG	p.P328P	PLEKHG2_uc010xuy.1_Silent_p.P269P|PLEKHG2_uc002olj.2_Silent_p.P328P|PLEKHG2_uc010xva.1_Silent_p.P135P	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	328	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGGGTGGCCCCCGGCTACGAG	0.662													G	39908646	G	G	39908646	2	3	257	1	0	0	0	0	0	0	0	1	12069	610	22	5		5	PLEKHG2	19	39908646	Silent	SNP	C	TCGA-76-4925-01A-01D-1486-08	20332474	39908646	19220337	71	18461											
KLK5	25818	broad.mit.edu	37	chr19	51453308	51453308	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagctcccaggtcctggttGctcccagagggcacggtgtt	13	14	0	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr19:51453308G>A	uc002pue.2	-	4	356	c.138C>T	c.(136-138)AGC>AGT	p.S46S	KLK5_uc002puf.2_Silent_p.S46S|KLK5_uc002pug.2_Silent_p.S46S	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	46				Missing (in Ref. 3; AAG33358).	epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		GGTCCTGGTTGCTCCCAGAGG	0.612													A	51453308	A	A	51453308	2	1	257	1	0	0	0	0	0	0	0	1	8407	1310	46	3		3	KLK5	19	51453308	Silent	SNP	G	TCGA-76-4925-01A-01D-1486-08	11544662	51453308	7675675	72	18462											
GFRA4	64096	broad.mit.edu	37	chr20	3641311	3641311	+	Frame_Shift_Del	DEL	C	-	-													aggggtgacggcggtgcctgCggggaccctgagggcgaagt							TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr20:3641311delC	uc002wio.2	-	3	589	c.589delG	c.(589-591)GCAfs	p.A197fs	GFRA4_uc002win.2_Intron|GFRA4_uc002wip.1_Frame_Shift_Del_p.P170fs	NM_145762	NP_665705	Q9GZZ7	GFRA4_HUMAN	GDNF family receptor alpha 4 isoform b	197						anchored to membrane|extracellular region|plasma membrane	receptor activity				0						GCGGTGCCTGCGGGGACCCTG	0.731													-	3641311	-	-	3641311	7	5	257	1	0	1	0	1	0	0	0	0	6350	768	27	0	322	0	GFRA4	20	3641311	Frame_Shift_Del	DEL	C	TCGA-76-4925-01A-01D-1486-08		3641311	59384209	73	18463											
PROKR2	128674	broad.mit.edu	37	chr20	5283350	5283350	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggccgtttgataattcatcCgtggtttcaaggggtgaacg	13	7	2	2			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr20:5283350C>T	uc010zqw.1	-	2	491	c.491G>A	c.(490-492)CGG>CAG	p.R164Q	PROKR2_uc010zqx.1_Missense_Mutation_p.R164Q|PROKR2_uc010zqy.1_Missense_Mutation_p.R164Q	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	164	Cytoplasmic (Potential).		R -> Q (in KAL3).			integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						ATAATTCATCCGTGGTTTCAA	0.493										HNSCC(71;0.22)			T	5283350	T	T	5283350	3	4	257	1	0	0	0	0	1	0	0	0	12553	652	23	2	666	2	PROKR2	20	5283350	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	1642039	5283350	57742170	74	18464											
TFAP2C	7022	broad.mit.edu	37	chr20	55206728	55206728	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggctccacgacatgcctcaCcagatggacgaggtgcaggt	14	12	1	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr20:55206728C>A	uc002xya.2	+	2	759	c.516C>A	c.(514-516)CAC>CAA	p.H172Q	TFAP2C_uc010zzi.1_Missense_Mutation_p.H3Q	NM_003222	NP_003213	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma	172					cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Colorectal(105;0.229)			ACATGCCTCACCAGATGGACG	0.711													A	55206728	A	A	55206728	3	1	257	1	0	0	0	0	1	0	0	0	15786	506	18	5	522	5	TFAP2C	20	55206728	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08	49923378	55206728	7818792	75	18465											
TMPRSS15	5651	broad.mit.edu	37	chr21	19698772	19698772	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaatccccaagtgatagccaGtagtaaagtttgctttaaac	8	8	0	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chr21:19698772G>T	uc002ykw.2	-	16	1929	c.1898C>A	c.(1897-1899)ACT>AAT	p.T633N		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	633	Extracellular (Potential).|CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						GTGATAGCCAGTAGTAAAGTT	0.438													T	19698772	T	T	19698772	3	4	257	1	0	0	0	0	1	0	0	0	16243	1029	36	5	1201	5	TMPRSS15	21	19698772	Missense_Mutation	SNP	G	TCGA-76-4925-01A-01D-1486-08		19698772	28431123	76	18466											
BHLHB9	80823	broad.mit.edu	37	chrX	102004405	102004405	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctggggccgattgcaaacCtaggtcaggggctgaggagg	19	8	1	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chrX:102004405C>T	uc010nog.2	+	4	1053	c.482C>T	c.(481-483)CCT>CTT	p.P161L	BHLHB9_uc011mrq.1_Missense_Mutation_p.P161L|BHLHB9_uc011mrr.1_Missense_Mutation_p.P161L|BHLHB9_uc011mrs.1_Missense_Mutation_p.P161L|BHLHB9_uc011mrt.1_Missense_Mutation_p.P161L|BHLHB9_uc004ejo.2_Missense_Mutation_p.P161L|BHLHB9_uc011mru.1_Missense_Mutation_p.P161L|BHLHB9_uc011mrv.1_Missense_Mutation_p.P161L	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	161						cytoplasm|nucleus	binding			ovary(2)	2						GATTGCAAACCTAGGTCAGGG	0.493													T	102004405	T	T	102004405	3	4	257	1	0	0	0	0	1	0	0	0	1420	681	24	3	484	3	BHLHB9	23	102004405	Missense_Mutation	SNP	C	TCGA-76-4925-01A-01D-1486-08		102004405	53266155	77	18467											
FAM127C	441518	broad.mit.edu	37	chrX	134156181	134156181	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctcctcccatccaaagacCcgcttcatctcagccaggaa	5	18	2	1			TCGA-76-4925-01A-01D-1486-08	TCGA-76-4925-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	ca2fa3da-18d6-4e8b-8081-b07022ead6a8	90829cdd-ee26-49f2-b080-1a17d4f1351b	g.chrX:134156181C>T	uc004eyc.1	-	1	386	c.309G>A	c.(307-309)CGG>CGA	p.R103R		NM_001078173	NP_001071641	Q17RB0	F127C_HUMAN	family with sequence similarity 127, member C	103											0	Acute lymphoblastic leukemia(192;0.000127)					ATCCAAAGACCCGCTTCATCT	0.667													T	134156181	T	T	134156181	2	4	257	1	0	0	0	0	0	0	0	1	5433	610	22	3		3	FAM127C	23	134156181	Silent	SNP	C	TCGA-76-4925-01A-01D-1486-08	32151776	134156181	21114379	78	18468											
ATAD3B	83858	broad.mit.edu	37	chr1	1412700	1412700	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcagatgcaggagcagacGctgcagttggagcaacagtc	15	10	0	2	rs142559400	byFrequency	TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr1:1412700G>A	uc001afv.2	+	2	353	c.252G>A	c.(250-252)ACG>ACA	p.T84T	ATAD3B_uc001afw.2_5'Flank|ATAD3B_uc001afx.2_5'Flank	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	84	Potential.						ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		AGGAGCAGACGCTGCAGTTGG	0.617													A	1412700	A	A	1412700	2	1	258	1	0	0	0	0	0	0	0	1	1074	1074	38	1		1	ATAD3B	1	1412700	Silent	SNP	G	TCGA-76-4926-01B-01D-1486-08		1412700	247837921	1	18469											
MMEL1	79258	broad.mit.edu	37	chr1	2524281	2524281	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcgctcacgttctgttcGtctgccaggtcccaggagta	12	13	3	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr1:2524281G>A	uc001ajy.2	-	20	2206	c.1992C>T	c.(1990-1992)GAC>GAT	p.D664D	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	664	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CGTTCTGTTCGTCTGCCAGGT	0.637													A	2524281	A	A	2524281	2	1	258	1	0	0	0	0	0	0	0	1	9646	1136	40	1		1	MMEL1	1	2524281	Silent	SNP	G	TCGA-76-4926-01B-01D-1486-08	1111581	2524281	246726340	2	18470											
PLEKHM2	23207	broad.mit.edu	37	chr1	16044415	16044415	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctggctgtacctggccctcaAcgagaactccttggagagct	11	13	1	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr1:16044415A>G	uc010obo.1	+	4	532	c.305A>G	c.(304-306)AAC>AGC	p.N102S		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	102	RUN.|Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		CTGGCCCTCAACGAGAACTCC	0.572													G	16044415	G	G	16044415	3	3	258	1	0	0	0	0	1	0	0	0	12081	43	2	4	319	4	PLEKHM2	1	16044415	Missense_Mutation	SNP	A	TCGA-76-4926-01B-01D-1486-08	13520134	16044415	233206206	3	18471											
ZSWIM5	57643	broad.mit.edu	37	chr1	45508897	45508897	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agggctagacttaccaagccAcagtggctggccttgggaat	13	10	0	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr1:45508897A>G	uc001cnd.2	-	6	1831	c.1603T>C	c.(1603-1605)TGG>CGG	p.W535R		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	535							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TTACCAAGCCACAGTGGCTGG	0.488													G	45508897	G	G	45508897	3	3	258	1	0	0	0	0	1	0	0	0	18241	159	6	4	1990	4	ZSWIM5	1	45508897	Missense_Mutation	SNP	A	TCGA-76-4926-01B-01D-1486-08	29464482	45508897	203741724	4	18472											
VPS45	11311	broad.mit.edu	37	chr1	150049176	150049176	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgtttttaacaaaaagggtcGaaattgggatccagcccagc	10	8	0	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr1:150049176G>A	uc001etp.2	+	6	1016	c.443G>A	c.(442-444)CGA>CAA	p.R148Q	VPS45_uc010pbp.1_Intron|VPS45_uc010pbq.1_Missense_Mutation_p.R112Q|VPS45_uc010pbs.1_Intron|VPS45_uc001etq.2_5'Flank|VPS45_uc009wlm.1_Intron|VPS45_uc010pbr.1_Missense_Mutation_p.R112Q	NM_007259	NP_009190	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45A	148					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				central_nervous_system(1)|skin(1)	2	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAAAAGGGTCGAAATTGGGAT	0.353													A	150049176	A	A	150049176	3	1	258	1	0	0	0	0	1	0	0	0	17208	1058	37	2	465	2	VPS45	1	150049176	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	104540279	150049176	99201445	5	18473											
KPRP	448834	broad.mit.edu	37	chr1	152733551	152733551	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccctgcagggagacttggcGcagccccagcccatgctggg	15	15	0	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr1:152733551G>A	uc001fal.1	+	2	1545	c.1487G>A	c.(1486-1488)CGC>CAC	p.R496H		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	496	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGACTTGGCGCAGCCCCAGC	0.647													A	152733551	A	A	152733551	3	1	258	1	0	0	0	0	1	0	0	0	8436	1087	38	1	1489	1	KPRP	1	152733551	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	2684375	152733551	96517070	6	18474											
KIF26B	55083	broad.mit.edu	37	chr1	245862232	245862232	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgaagattctggaacaccGccagcagaggatcgccgagg	14	11	1	3			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr1:245862232G>A	uc001ibf.1	+	14	6511	c.6071G>A	c.(6070-6072)CGC>CAC	p.R2024H		NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	2024					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R2024H(1)		ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CTGGAACACCGCCAGCAGAGG	0.572													A	245862232	A	A	245862232	3	1	258	1	0	0	0	0	1	0	0	0	8295	1087	38	1	6125	1	KIF26B	1	245862232	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	93128681	245862232	3388389	7	18475											
OR2W3	343171	broad.mit.edu	37	chr1	248059267	248059267	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgaccggtgtgtggctatcTgcaagcccctgcactacatg	11	12	1	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr1:248059267T>G	uc001idp.1	+	3	648	c.379T>G	c.(379-381)TGC>GGC	p.C127G	OR2W3_uc010pzb.1_Missense_Mutation_p.C127G	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGTGGCTATCTGCAAGCCCCT	0.607													G	248059267	G	G	248059267	3	3	258	1	0	0	0	0	1	0	0	0	11033	1580	55	5	381	5	OR2W3	1	248059267	Missense_Mutation	SNP	T	TCGA-76-4926-01B-01D-1486-08	2197035	248059267	1191354	8	18476											
TPO	7173	broad.mit.edu	37	chr2	1457495	1457495	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatggggcgcctccaacaCggccctggcacgatggctcc	13	16	0	1	rs139312937		TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr2:1457495C>T	uc002qww.2	+	6	603	c.512C>T	c.(511-513)ACG>ATG	p.T171M	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.T171M|TPO_uc002qwr.2_Missense_Mutation_p.T171M|TPO_uc002qwx.2_Missense_Mutation_p.T171M|TPO_uc010yio.1_Missense_Mutation_p.T171M|TPO_uc010yip.1_Missense_Mutation_p.T171M	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	171	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCCTCCAACACGGCCCTGGCA	0.587													T	1457495	T	T	1457495	3	4	258	1	0	0	0	0	1	0	0	0	16407	536	19	1	530	1	TPO	2	1457495	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08		1457495	241741878	9	18477											
TTN	7273	broad.mit.edu	37	chr2	179438088	179438088	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttatcacgccgttccacaatAtaattgatgatttcacttcc	4	11	2	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr2:179438088A>G	uc010zfg.1	-	275	65291	c.65067T>C	c.(65065-65067)TAT>TAC	p.Y21689Y	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.Y15384Y|TTN_uc010zfi.1_Silent_p.Y15317Y|TTN_uc010zfj.1_Silent_p.Y15192Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22616							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTCCACAATATAATTGATGA	0.408													G	179438088	G	G	179438088	2	3	258	1	0	0	0	0	0	0	0	1	16732	456	16	4		4	TTN	2	179438088	Silent	SNP	A	TCGA-76-4926-01B-01D-1486-08	177980593	179438088	63761285	10	18478											
CELSR3	1951	broad.mit.edu	37	chr3	48694272	48694272	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccgggcgggcagcggcagcGcaggccagcgatgggctgga	20	12	0	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr3:48694272G>A	uc003cul.2	-	2	4539	c.4258C>T	c.(4258-4260)CGC>TGC	p.R1420C	CELSR3_uc003cuf.1_Missense_Mutation_p.R1490C	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1420	Extracellular (Potential).|EGF-like 1; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CAGCGGCAGCGCAGGCCAGCG	0.672													A	48694272	A	A	48694272	3	1	258	1	0	0	0	0	1	0	0	0	3223	1087	38	1	5816	1	CELSR3	3	48694272	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08		48694272	149328158	11	18479											
LRRC66	339977	broad.mit.edu	37	chr4	52862310	52862310	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaatcctgctctggggagtgCccccgttggcctcctcactc	10	16	2	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr4:52862310C>A	uc003gzi.2	-	4	891	c.878G>T	c.(877-879)GGC>GTC	p.G293V		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	293						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CTGGGGAGTGCCCCCGTTGGC	0.483													A	52862310	A	A	52862310	3	1	258	1	0	0	0	0	1	0	0	0	9018	739	26	5	1768	5	LRRC66	4	52862310	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08		52862310	138291966	12	18480											
FRAS1	80144	broad.mit.edu	37	chr4	79421050	79421050	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggtgtggattattacccaaaGagccgagtcttgaagttcag	12	7	2	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr4:79421050G>A	uc003hlb.2	+	61	9731	c.9291G>A	c.(9289-9291)AAG>AAA	p.K3097K	FRAS1_uc003hlc.1_Silent_p.K99K	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3092	Calx-beta 5.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ATTACCCAAAGAGCCGAGTCT	0.388													A	79421050	A	A	79421050	2	1	258	1	0	0	0	0	0	0	0	1	6042	933	33	3		3	FRAS1	4	79421050	Silent	SNP	G	TCGA-76-4926-01B-01D-1486-08	26558740	79421050	111733226	13	18481											
PRKG2	5593	broad.mit.edu	37	chr4	82126062	82126062	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctccttcaaatggtactccCgctcctggatctcagcatcc	7	16	2	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr4:82126062C>T	uc003hmh.2	-	1	154	c.140G>A	c.(139-141)CGG>CAG	p.R47Q	PRKG2_uc011cch.1_Missense_Mutation_p.R47Q	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	47					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						ATGGTACTCCCGCTCCTGGAT	0.557													T	82126062	T	T	82126062	3	4	258	1	0	0	0	0	1	0	0	0	12523	652	23	2	2220	2	PRKG2	4	82126062	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	2705012	82126062	109028214	14	18482											
RXFP1	59350	broad.mit.edu	37	chr4	159533468	159533468	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgaagataatcacctcagtCgaatttccccaccaacattt	4	12	2	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr4:159533468C>T	uc003ipz.2	+	8	716	c.634C>T	c.(634-636)CGA>TGA	p.R212*	RXFP1_uc010iqj.1_Nonsense_Mutation_p.R41*|RXFP1_uc011cja.1_Nonsense_Mutation_p.R131*|RXFP1_uc010iqo.2_Nonsense_Mutation_p.R212*|RXFP1_uc011cjb.1_Nonsense_Mutation_p.R158*|RXFP1_uc010iqk.2_Nonsense_Mutation_p.R80*|RXFP1_uc011cjc.1_Nonsense_Mutation_p.R131*|RXFP1_uc011cjd.1_Nonsense_Mutation_p.R131*|RXFP1_uc010iql.2_Nonsense_Mutation_p.R80*|RXFP1_uc011cje.1_Nonsense_Mutation_p.R239*|RXFP1_uc010iqm.2_Nonsense_Mutation_p.R179*|RXFP1_uc011cjf.1_Nonsense_Mutation_p.R82*|RXFP1_uc010iqn.2_Nonsense_Mutation_p.R158*	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	212	LRR 3.|Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TCACCTCAGTCGAATTTCCCC	0.294													T	159533468	T	T	159533468	4	4	258	1	0	0	0	0	0	1	0	0	13759	876	31	2	664	2	RXFP1	4	159533468	Nonsense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	77407406	159533468	31620808	15	18483											
SLC6A18	348932	broad.mit.edu	37	chr5	1244838	1244838	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtggcttacatcatcctcCtgttctggaagccactgaga	9	11	2	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr5:1244838C>T	uc003jby.1	+	11	1735	c.1612C>T	c.(1612-1614)CTG>TTG	p.L538L		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	538	Helical; Name=11; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CATCATCCTCCTGTTCTGGAA	0.617													T	1244838	T	T	1244838	2	4	258	1	0	0	0	0	0	0	0	1	14681	680	24	3		3	SLC6A18	5	1244838	Silent	SNP	C	TCGA-76-4926-01B-01D-1486-08		1244838	179670422	16	18484											
NSUN2	54888	broad.mit.edu	37	chr5	6622137	6622137	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaatgcatacctggaaagGggacattcatgtcggcatgt	11	9	1	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr5:6622137G>A	uc003jdu.2	-	6	679	c.614C>T	c.(613-615)CCC>CTC	p.P205L	NSUN2_uc003jdt.2_5'Flank|NSUN2_uc011cmk.1_Missense_Mutation_p.P170L|NSUN2_uc003jdv.2_Intron	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	205						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						ACCTGGAAAGGGGACATTCAT	0.413													A	6622137	A	A	6622137	3	1	258	1	0	0	0	0	1	0	0	0	10678	1232	43	3	1745	3	NSUN2	5	6622137	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	5377299	6622137	174293123	17	18485											
UTP15	84135	broad.mit.edu	37	chr5	72866479	72866480	+	Nonsense_Mutation	DNP	GG	TA	TA													gtgttctctccgttgagcatGggcagccagtggagagtgtc							TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr5:72866479_72866480GG>TA	uc003kcw.1	+	6	839_840	c.616_617GG>TA	c.(616-618)GGG>TAG	p.G206*	UTP15_uc011cso.1_Nonsense_Mutation_p.G187*|UTP15_uc011csp.1_Nonsense_Mutation_p.G16*|UTP15_uc010ize.1_Nonsense_Mutation_p.G206*	NM_032175	NP_115551	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein,	206	WD 5.				rRNA processing	cytoplasm|nucleolus					0		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		CGTTGAGCATGGGCAGCCAGTG	0.401													TA	72866480	TA	TA	72866479	4	4	258	1	0	0	0	0	0	1	0	0	17094	1348	47	5	634	5	UTP15	5	72866479	Nonsense_Mutation	DNP	GG	TCGA-76-4926-01B-01D-1486-08	66244342	72866479	108048781	18	18486											
CMYA5	202333	broad.mit.edu	37	chr5	79026182	79026182	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttagtagaagaagagatcGtagaacttgattacccagaa	9	5	0	6			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr5:79026182G>A	uc003kgc.2	+	2	1666	c.1594G>A	c.(1594-1596)GTA>ATA	p.V532I		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	532	Glu-rich.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGAAGAGATCGTAGAACTTGA	0.418													A	79026182	A	A	79026182	3	1	258	1	0	0	0	0	1	0	0	0	3590	1145	40	1	1600	1	CMYA5	5	79026182	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	6159703	79026182	101889078	19	18487											
PCDHGA1	56114	broad.mit.edu	37	chr5	140712004	140712004	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcccctctccgcagagcccGgctacctggtgaccaaggtg	12	17	1	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr5:140712004G>A	uc003lji.1	+	1	1753	c.1753G>A	c.(1753-1755)GGC>AGC	p.G585S	PCDHGA1_uc011dan.1_Missense_Mutation_p.G585S	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	585	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCAGAGCCCGGCTACCTGGT	0.677													A	140712004	A	A	140712004	3	1	258	1	0	0	0	0	1	0	0	0	11550	1116	39	2	1755	2	PCDHGA1	5	140712004	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	61685822	140712004	40203256	20	18488											
BTN1A1	696	broad.mit.edu	37	chr6	26508920	26508920	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gggaggtggaggtgggagacAggactgactgggcaatcggc	21	6	0	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr6:26508920A>C	uc003nif.3	+	7	1119	c.1099A>C	c.(1099-1101)AGG>CGG	p.R367R		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	367	B30.2/SPRY.|Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						GGTGGGAGACAGGACTGACTG	0.532													C	26508920	C	C	26508920	2	2	258	1	0	0	0	0	0	0	0	1	1559	179	7	5		5	BTN1A1	6	26508920	Silent	SNP	A	TCGA-76-4926-01B-01D-1486-08		26508920	144606147	21	18489											
KCTD20	222658	broad.mit.edu	37	chr6	36437942	36437942	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggccagctgcttagtggatgAtactttagctgtagcccaag	12	9	0	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr6:36437942A>G	uc003ome.2	+	2	459	c.68A>G	c.(67-69)GAT>GGT	p.D23G	KCTD20_uc011dtm.1_5'UTR|KCTD20_uc011dtn.1_5'UTR|KCTD20_uc010jwk.2_Missense_Mutation_p.D23G|KCTD20_uc011dto.1_Intron	NM_173562	NP_775833	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerisation domain	23						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2						TTAGTGGATGATACTTTAGCT	0.473													G	36437942	G	G	36437942	3	3	258	1	0	0	0	0	1	0	0	0	8108	333	12	4	70	4	KCTD20	6	36437942	Missense_Mutation	SNP	A	TCGA-76-4926-01B-01D-1486-08	9929022	36437942	134677125	22	18490											
TFAP2D	83741	broad.mit.edu	37	chr6	50740520	50740520	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaactcggagaaagctccCctgcggaaaacttcagaggc	11	13	1	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr6:50740520C>T	uc003paf.2	+	8	1814	c.1302C>T	c.(1300-1302)CCC>CCT	p.P434P	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	434							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					AGAAAGCTCCCCTGCGGAAAA	0.483													T	50740520	T	T	50740520	2	4	258	1	0	0	0	0	0	0	0	1	15787	610	22	3		3	TFAP2D	6	50740520	Silent	SNP	C	TCGA-76-4926-01B-01D-1486-08	14302578	50740520	120374547	23	18491											
IBTK	25998	broad.mit.edu	37	chr6	82924063	82924066	+	Frame_Shift_Del	DEL	ACTA	-	-													ggtttgctcttctgcctctcActaactgtttgagcttgatt							TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr6:82924063_82924066delACTA	uc003pjl.1	-	12	2609_2612	c.2082_2085delTAGT	c.(2080-2085)GTTAGTfs	p.V694fs	IBTK_uc011dyv.1_Frame_Shift_Del_p.V694fs|IBTK_uc011dyw.1_Intron|IBTK_uc010kbi.1_Frame_Shift_Del_p.V388fs|IBTK_uc003pjm.2_Frame_Shift_Del_p.V694fs	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	694_695					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TCTGCCTCTCACTAACTGTTTGAG	0.338													-	82924066	-	-	82924063	7	5	258	1	0	1	0	1	0	0	0	0	7476	156	6	0	2048	0	IBTK	6	82924063	Frame_Shift_Del	DEL	ACTA	TCGA-76-4926-01B-01D-1486-08	32183543	82924063	88191004	24	18492											
HDAC9	9734	broad.mit.edu	37	chr7	18624954	18624954	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tggagcccatctcacctttaGacctaaggacagacctcagg	9	13	2	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr7:18624954G>A	uc003suh.2	+	2	114	c.73G>A	c.(73-75)GAC>AAC	p.D25N	HDAC9_uc003sue.2_Missense_Mutation_p.D25N|HDAC9_uc011jyd.1_Missense_Mutation_p.D25N|HDAC9_uc003sui.2_Missense_Mutation_p.D25N|HDAC9_uc003suj.2_Missense_Mutation_p.D25N|HDAC9_uc011jya.1_Missense_Mutation_p.D66N|HDAC9_uc003sua.1_Missense_Mutation_p.D44N|HDAC9_uc011jyb.1_Missense_Mutation_p.D25N|HDAC9_uc003sud.1_Missense_Mutation_p.D25N|HDAC9_uc011jyc.1_Missense_Mutation_p.D25N|HDAC9_uc003suf.1_Missense_Mutation_p.D53N|HDAC9_uc010kud.1_Missense_Mutation_p.D25N|HDAC9_uc011jye.1_5'UTR|HDAC9_uc011jyf.1_5'UTR	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	25	Interaction with CTBP1 (By similarity).				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CTCACCTTTAGACCTAAGGAC	0.498													A	18624954	A	A	18624954	3	1	258	1	0	0	0	0	1	0	0	0	7014	942	33	3	79	3	HDAC9	7	18624954	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08		18624954	140513709	25	18493											
BMPER	168667	broad.mit.edu	37	chr7	34118619	34118619	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggtgaagaacgacgcccGccggacacgctccttctcgt	12	15	1	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr7:34118619G>A	uc011kap.1	+	12	1343	c.1229G>A	c.(1228-1230)CGC>CAC	p.R410H		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	410	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AACGACGCCCGCCGGACACGC	0.622													A	34118619	A	A	34118619	3	1	258	1	0	0	0	0	1	0	0	0	1468	1087	38	1	1275	1	BMPER	7	34118619	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	15493665	34118619	125020044	26	18494											
EGFR	1956	broad.mit.edu	37	chr7	55220274	55220274	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcccagcagtgctccgggCgctgccgtggcaagtccccc	14	17	0	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr7:55220274C>T	uc003tqk.2	+	6	910	c.664C>T	c.(664-666)CGC>TGC	p.R222C	EGFR_uc003tqh.2_Missense_Mutation_p.R222C|EGFR_uc003tqi.2_Missense_Mutation_p.R222C|EGFR_uc003tqj.2_Missense_Mutation_p.R222C|EGFR_uc010kzg.1_Missense_Mutation_p.R177C|EGFR_uc011kco.1_Missense_Mutation_p.R169C|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	222	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.R222C(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGCTCCGGGCGCTGCCGTGG	0.597		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55220274	T	T	55220274	3	4	258	1	0	0	0	0	1	0	0	0	4967	768	27	1	686	1	EGFR	7	55220274	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	21101655	55220274	103918389	27	18495											
NSUN5	55695	broad.mit.edu	37	chr7	72722785	72722785	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagctgcagcatacagcccCatgttcccgcgcgcctttac	9	17	0	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr7:72722785C>T	uc003txw.2	-	1	39	c.3G>A	c.(1-3)ATG>ATA	p.M1I	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Missense_Mutation_p.M1I|NSUN5_uc003txx.2_Missense_Mutation_p.M1I|NSUN5_uc011kev.1_Missense_Mutation_p.M1I	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	1							methyltransferase activity				0		Lung NSC(55;0.163)				CATACAGCCCCATGTTCCCGC	0.657													T	72722785	T	T	72722785	3	4	258	1	0	0	0	0	1	0	0	0	10681	594	21	3	1458	3	NSUN5	7	72722785	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	17502511	72722785	86415878	28	18496											
OR2A5	393046	broad.mit.edu	37	chr7	143748358	143748359	+	Frame_Shift_Ins	INS	-	A	A													acccgatgctgaaccccttgINSatctatagcctgaggaacgc							TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr7:143748358_143748359insA	uc011ktw.1	+	1	864_865	c.864_865insA	c.(862-867)TTGATCfs	p.L288fs		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	288_289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TGAACCCCTTGATCTATAGCCT	0.525													A	143748359	A	A	143748358	7	5	258	1	0	1	1	0	0	0	0	0	10981	1281	45	0	866	0	OR2A5	7	143748358	Frame_Shift_Ins	INS	-	TCGA-76-4926-01B-01D-1486-08	71025573	143748358	15390305	29	18497											
NEFM	4741	broad.mit.edu	37	chr8	24775980	24775980	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggggggagatggtgctaccaAatacatcactaaatctgtaa	11	7	2	1	rs145571992		TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr8:24775980A>G	uc003xed.3	+	3	2645	c.2612A>G	c.(2611-2613)AAA>AGA	p.K871R	NEFM_uc011lac.1_Missense_Mutation_p.K653R|NEFM_uc010lue.2_Missense_Mutation_p.K495R	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	871	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GGTGCTACCAAATACATCACT	0.428													G	24775980	G	G	24775980	3	3	258	1	0	0	0	0	1	0	0	0	10316	14	1	4	2622	4	NEFM	8	24775980	Missense_Mutation	SNP	A	TCGA-76-4926-01B-01D-1486-08		24775980	121588042	30	18498											
RB1CC1	9821	broad.mit.edu	37	chr8	53570293	53570293	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatagtttcaaaatcaaacGtatgtgcatcaatactatct	5	7	4	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr8:53570293G>A	uc003xre.3	-	15	2654	c.2096C>T	c.(2095-2097)ACG>ATG	p.T699M	RB1CC1_uc003xrf.3_Missense_Mutation_p.T699M	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	699					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AAAATCAAACGTATGTGCATC	0.398													A	53570293	A	A	53570293	3	1	258	1	0	0	0	0	1	0	0	0	13099	1145	40	1	2728	1	RB1CC1	8	53570293	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	28794313	53570293	92793729	31	18499											
RIMS2	9699	broad.mit.edu	37	chr8	104898339	104898339	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcataaatcaaagaaaggCggtaaaatgcgccagatttc	8	9	2	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr8:104898339C>T	uc003yls.2	+	2	1087	c.846C>T	c.(844-846)GGC>GGT	p.G282G	RIMS2_uc003ylp.2_Silent_p.G504G|RIMS2_uc003ylw.2_Silent_p.G312G|RIMS2_uc003ylq.2_Silent_p.G312G|RIMS2_uc003ylr.2_Silent_p.G312G	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	535					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CAAAGAAAGGCGGTAAAATGC	0.433										HNSCC(12;0.0054)			T	104898339	T	T	104898339	2	4	258	1	0	0	0	0	0	0	0	1	13368	755	27	1		1	RIMS2	8	104898339	Silent	SNP	C	TCGA-76-4926-01B-01D-1486-08	51328046	104898339	41465683	32	18500											
RIMS2	9699	broad.mit.edu	37	chr8	105257209	105257209	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aaacaggcctggccgtggaaAtgaggaactggatgactcga	14	8	0	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr8:105257209A>T	uc003yls.2	+	24	3695	c.3454A>T	c.(3454-3456)ATG>TTG	p.M1152L	RIMS2_uc003ylp.2_Missense_Mutation_p.M1134L|RIMS2_uc003ylw.2_Missense_Mutation_p.M1141L|RIMS2_uc003ylq.2_Missense_Mutation_p.M948L|RIMS2_uc003ylr.2_Missense_Mutation_p.M973L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1196					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCCGTGGAAATGAGGAACTG	0.473										HNSCC(12;0.0054)			T	105257209	T	T	105257209	3	4	258	1	0	0	0	0	1	0	0	0	13368	101	4	5	3674	5	RIMS2	8	105257209	Missense_Mutation	SNP	A	TCGA-76-4926-01B-01D-1486-08	358870	105257209	41106813	33	18501											
TG	7038	broad.mit.edu	37	chr8	134107297	134107297	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctcttccagggaggctccGcactctccccggccgccgtc	10	19	2	0	rs139465983	byFrequency	TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr8:134107297G>A	uc003ytw.2	+	42	7290	c.7249G>A	c.(7249-7251)GCA>ACA	p.A2417T	TG_uc010mdw.2_Missense_Mutation_p.A1176T|TG_uc011ljb.1_Missense_Mutation_p.A786T|TG_uc011ljc.1_Missense_Mutation_p.A550T|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2417					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGGAGGCTCCGCACTCTCCCC	0.587													A	134107297	A	A	134107297	3	1	258	1	0	0	0	0	1	0	0	0	15810	1087	38	1	7415	1	TG	8	134107297	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	28850088	134107297	12256725	34	18502											
CYP11B2	1585	broad.mit.edu	37	chr8	143999226	143999226	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggacagccagggcgctgccaCgcacacctctgcctttgccc	11	18	1	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr8:143999226C>T	uc003yxk.1	-	1	34	c.31G>A	c.(31-33)GTG>ATG	p.V11M		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	11					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGCGCTGCCACGCACACCTCT	0.612									Familial_Hyperaldosteronism_type_I				T	143999226	T	T	143999226	3	4	258	1	0	0	0	0	1	0	0	0	4146	536	19	1	1516	1	CYP11B2	8	143999226	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	9891929	143999226	2364796	35	18503											
RECQL4	9401	broad.mit.edu	37	chr8	145737371	145737371	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcctcttcctcaaagtagcGgccgagcaggtccttgagcc	10	14	2	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr8:145737371G>A	uc003zdj.2	-	20	3348	c.3316C>T	c.(3316-3318)CGC>TGC	p.R1106C		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	1106					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TCAAAGTAGCGGCCGAGCAGG	0.677			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				A	145737371	A	A	145737371	3	1	258	1	0	0	0	0	1	0	0	0	13202	1116	39	2	322	2	RECQL4	8	145737371	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	1738145	145737371	626651	36	18504											
BNC2	54796	broad.mit.edu	37	chr9	16435843	16435843	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctcatgtaaaacatgtcGtaagtggggtctgtaaattc	11	6	2	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr9:16435843G>A	uc003zml.2	-	6	2489	c.2349C>T	c.(2347-2349)TAC>TAT	p.Y783Y	BNC2_uc011lmw.1_Silent_p.Y688Y|BNC2_uc003zmm.2_Silent_p.Y741Y|BNC2_uc003zmq.1_Silent_p.Y797Y|BNC2_uc003zmr.1_Silent_p.Y820Y|BNC2_uc003zmp.1_Silent_p.Y811Y|BNC2_uc010mij.1_Silent_p.Y705Y|BNC2_uc011lmv.1_Silent_p.Y609Y|BNC2_uc003zmo.1_Silent_p.Y705Y|BNC2_uc003zmj.2_Silent_p.Y548Y|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Silent_p.Y548Y|BNC2_uc003zmn.1_Silent_p.Y548Y	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	783					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		AAAACATGTCGTAAGTGGGGT	0.493													A	16435843	A	A	16435843	2	1	258	1	0	0	0	0	0	0	0	1	1475	1140	40	1		1	BNC2	9	16435843	Silent	SNP	G	TCGA-76-4926-01B-01D-1486-08		16435843	124777588	37	18505											
PGM5	5239	broad.mit.edu	37	chr9	71098902	71098902	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggggagccatgtctacagcGtggcgaagacggatagtttt	15	7	1	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr9:71098902G>A	uc004agr.2	+	9	1646	c.1417G>A	c.(1417-1419)GTG>ATG	p.V473M		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	473					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						TGTCTACAGCGTGGCGAAGAC	0.502													A	71098902	A	A	71098902	3	1	258	1	0	0	0	0	1	0	0	0	11801	1145	40	1	1451	1	PGM5	9	71098902	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	54663059	71098902	70114529	38	18506											
NACC2	138151	broad.mit.edu	37	chr9	138903727	138903727	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcggagcccatgaccgtgcGgtacatctccacgccctccg	12	17	1	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr9:138903727G>A	uc004cgw.2	-	6	1555	c.1399C>T	c.(1399-1401)CGC>TGC	p.R467C	NACC2_uc010nbh.2_Missense_Mutation_p.R106C|uc004cgv.3_5'Flank	NM_144653	NP_653254	Q96BF6	NACC2_HUMAN	BTB (POZ) domain containing 14A	467					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization	nuclear body					0						ATGACCGTGCGGTACATCTCC	0.697													A	138903727	A	A	138903727	3	1	258	1	0	0	0	0	1	0	0	0	10136	1116	39	2	368	2	NACC2	9	138903727	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	67804825	138903727	2309704	39	18507											
CACNA1B	774	broad.mit.edu	37	chr9	141012523	141012523	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	agagatccctgtggggcggtCaggagcactggtgagcactc	16	10	1	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr9:141012523C>G	uc004cog.2	+	42	6048	c.5903C>G	c.(5902-5904)TCA>TGA	p.S1968*	CACNA1B_uc004coi.2_Nonsense_Mutation_p.S1180*	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1968	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GTGGGGCGGTCAGGAGCACTG	0.637													G	141012523	G	G	141012523	4	3	258	1	0	0	0	0	0	1	0	0	2539	838	29	5	6069	5	CACNA1B	9	141012523	Nonsense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	2108796	141012523	200908	40	18508											
ARHGAP21	57584	broad.mit.edu	37	chr10	24893240	24893240	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagaaacactctaataccaaCcttgattcccttcagactag	4	12	2	3			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr10:24893240C>T	uc001isb.2	-	12	3208	c.2721_splice	c.e12+1	p.K907_splice	ARHGAP21_uc010qdb.1_Splice_Site|ARHGAP21_uc009xkl.1_Splice_Site_p.K907_splice|ARHGAP21_uc010qdc.1_Splice_Site_p.K742_splice	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21						signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						CTAATACCAACCTTGATTCCC	0.274													T	24893240	T	T	24893240	5	4	258	1	0	0	0	0	0	0	1	0	871	521	18	3	3214	3	ARHGAP21	10	24893240	Splice_Site	SNP	C	TCGA-76-4926-01B-01D-1486-08		24893240	110641507	41	18509			1	45		2	2	13	N	T_C	2.790953e-05
ARHGAP21	57584	broad.mit.edu	37	chr10	24893252	24893252	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aataccaaccttgattccctTcagactagatacgtgcttaa	5	11	1	3			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr10:24893252T>C	uc001isb.2	-	12	3197	c.2710A>G	c.(2710-2712)AAG>GAG	p.K904E	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Missense_Mutation_p.K904E|ARHGAP21_uc010qdc.1_Missense_Mutation_p.K739E	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	903					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TTGATTCCCTTCAGACTAGAT	0.279													C	24893252	C	C	24893252	3	2	258	1	0	0	0	0	1	0	0	0	871	1792	62	4	3226	4	ARHGAP21	10	24893252	Missense_Mutation	SNP	T	TCGA-76-4926-01B-01D-1486-08	12	24893252	110641495	42	18510			1	45		2	2	13	N	T_C	2.790953e-05
OR52N2	390077	broad.mit.edu	37	chr11	5842404	5842404	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccacatacacatcatcgtggCcaacctttatctgctactgc	5	15	2	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr11:5842404C>G	uc010qzp.1	+	1	839	c.839C>G	c.(838-840)GCC>GGC	p.A280G	TRIM5_uc001mbq.1_Intron	NM_001005174	NP_001005174	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCATCGTGGCCAACCTTTAT	0.398													G	5842404	G	G	5842404	3	3	258	1	0	0	0	0	1	0	0	0	11128	739	26	5	841	5	OR52N2	11	5842404	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08		5842404	129164112	43	18511											
TPH1	7166	broad.mit.edu	37	chr11	18051095	18051095	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccaagtccgcaaaatactttCgacgtttacggtagacattg	8	10	0	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr11:18051095C>T	uc001mnp.2	-	4	460	c.434G>A	c.(433-435)CGA>CAA	p.R145Q	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	145					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	AAAATACTTTCGACGTTTACG	0.264													T	18051095	T	T	18051095	3	4	258	1	0	0	0	0	1	0	0	0	16398	884	31	2	928	2	TPH1	11	18051095	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	12208691	18051095	116955421	44	18512											
C11orf9	745	broad.mit.edu	37	chr11	61541579	61541579	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgagcccaagtacgtcaagaCgcccgagggcctcaagcccc	11	17	2	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr11:61541579C>G	uc001nsc.1	+	8	1352	c.1256C>G	c.(1255-1257)ACG>AGG	p.T419R	C11orf9_uc001nse.1_Missense_Mutation_p.T410R	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	419	NDT80.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						TACGTCAAGACGCCCGAGGGC	0.587													G	61541579	G	G	61541579	3	3	258	1	0	0	0	0	1	0	0	0	1671	536	19	5	1309	5	C11orf9	11	61541579	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	43490484	61541579	73464937	45	18513											
GPR137	56834	broad.mit.edu	37	chr11	64056613	64056613	+	Splice_Site	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cactcctctgctcttctcccAggtgccaggaccaggcggcc	10	18	3	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr11:64056613A>C	uc001nzg.1	+	8	1340	c.1032_splice	c.e8-2	p.R344_splice	GPR137_uc010rni.1_Splice_Site_p.R402_splice|GPR137_uc001nzf.2_Missense_Mutation_p.Q329P|GPR137_uc001nzi.2_Missense_Mutation_p.Q379P|GPR137_uc010rnj.1_3'UTR|KCNK4_uc009ypl.1_5'Flank|KCNK4_uc001nzj.1_5'Flank|KCNK4_uc001nzk.1_5'Flank|KCNK4_uc010rnk.1_5'Flank|KCNK4_uc001nzl.1_5'Flank|KCNK4_uc001nzm.3_5'Flank|KCNK4_uc001nzn.1_5'Flank	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137							integral to membrane				central_nervous_system(1)	1						CTCTTCTCCCAGGTGCCAGGA	0.657													C	64056613	C	C	64056613	5	2	258	1	0	0	0	0	0	0	1	0	6645	202	7	5	1344	5	GPR137	11	64056613	Splice_Site	SNP	A	TCGA-76-4926-01B-01D-1486-08	2515034	64056613	70949903	46	18514											
SCN4B	6330	broad.mit.edu	37	chr11	118014756	118014756	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttggggtcagacttctcattCttcacagtcccctctatgag	8	12	5	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr11:118014756C>T	uc001pse.2	-	3	497	c.255G>A	c.(253-255)AAG>AAA	p.K85K	SCN4B_uc010rxu.1_5'UTR|SCN4B_uc010rxv.1_Intron	NM_174934	NP_777594	Q8IWT1	SCN4B_HUMAN	sodium channel, voltage-gated, type IV, beta	85	Ig-like C2-type.|Extracellular (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.33e-05)|Epithelial(105;0.00126)		ACTTCTCATTCTTCACAGTCC	0.507													T	118014756	T	T	118014756	2	4	258	1	0	0	0	0	0	0	0	1	13921	912	32	3		3	SCN4B	11	118014756	Silent	SNP	C	TCGA-76-4926-01B-01D-1486-08	53958143	118014756	16991760	47	18515											
TMEM25	84866	broad.mit.edu	37	chr11	118404798	118404798	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgccacgggagaacatgtcCctcccgtccaaccttcagct	8	17	1	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr11:118404798C>T	uc010rye.1	+	7	1065	c.891C>T	c.(889-891)TCC>TCT	p.S297S	TMEM25_uc001ptk.3_Silent_p.S297S|TMEM25_uc001pth.2_Silent_p.S253S|TMEM25_uc009zad.2_Silent_p.S253S|TMEM25_uc001pti.2_Silent_p.S149S|TMEM25_uc010ryf.1_Silent_p.S200S|TMEM25_uc001ptl.2_Silent_p.S297S|TMEM25_uc001ptm.2_Silent_p.S253S|TMEM25_uc001ptn.2_Silent_p.S253S	NM_032780	NP_116169	Q86YD3	TMM25_HUMAN	transmembrane protein 25 isoform 1	297	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		AGAACATGTCCCTCCCGTCCA	0.532													T	118404798	T	T	118404798	2	4	258	1	0	0	0	0	0	0	0	1	16147	610	22	3		3	TMEM25	11	118404798	Silent	SNP	C	TCGA-76-4926-01B-01D-1486-08	390042	118404798	16601718	48	18516											
ADAMTS8	11095	broad.mit.edu	37	chr11	130284455	130284455	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ctccacttcctcctcaggtaGacagctgccttctgagcaga	8	15	2	3			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr11:130284455G>C	uc001qgg.3	-	5	1895	c.1537C>G	c.(1537-1539)CTA>GTA	p.L513V	ADAMTS8_uc001qgf.2_5'Flank	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	513	Disintegrin.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TCCTCAGGTAGACAGCTGCCT	0.637													C	130284455	C	C	130284455	3	2	258	1	0	0	0	0	1	0	0	0	272	933	33	5	1152	5	ADAMTS8	11	130284455	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	11879657	130284455	4722061	49	18517											
ARNTL2	56938	broad.mit.edu	37	chr12	27540171	27540171	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaatcctagactgcagaagGcttcttatttgtggttggat	10	6	1	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr12:27540171G>A	uc001rht.1	+	7	593	c.575G>A	c.(574-576)GGC>GAC	p.G192D	ARNTL2_uc001rhw.2_Missense_Mutation_p.G155D|ARNTL2_uc010sjp.1_Missense_Mutation_p.G155D|ARNTL2_uc001rhu.1_Missense_Mutation_p.G178D|ARNTL2_uc009zji.1_Missense_Mutation_p.G158D|ARNTL2_uc001rhv.1_Missense_Mutation_p.G144D	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	192	PAS 1.				circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					ACTGCAGAAGGCTTCTTATTT	0.274													A	27540171	A	A	27540171	3	1	258	1	0	0	0	0	1	0	0	0	968	1203	42	3	601	3	ARNTL2	12	27540171	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08		27540171	106311724	50	18518											
ESPL1	9700	broad.mit.edu	37	chr12	53663689	53663689	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgatcaaggcatcagctgtCctgagcaagagtatggaggc	13	9	2	3			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr12:53663689C>T	uc001sck.2	+	3	1054	c.963C>T	c.(961-963)GTC>GTT	p.V321V	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	321					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CATCAGCTGTCCTGAGCAAGA	0.577													T	53663689	T	T	53663689	2	4	258	1	0	0	0	0	0	0	0	1	5253	842	30	3		3	ESPL1	12	53663689	Silent	SNP	C	TCGA-76-4926-01B-01D-1486-08	26123518	53663689	80188206	51	18519											
TXNRD1	7296	broad.mit.edu	37	chr12	104705084	104705084	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttaggcttatcaggagggcaGacttcaaaagctactaaaaa	9	7	2	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr12:104705084G>A	uc010swk.1	+	5	453	c.431G>A	c.(430-432)AGA>AAA	p.R144K	TXNRD1_uc010swl.1_5'UTR|TXNRD1_uc010swm.1_Missense_Mutation_p.R46K|TXNRD1_uc010swn.1_5'UTR|TXNRD1_uc010swo.1_5'UTR|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Missense_Mutation_p.R44K|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.R60K|TXNRD1_uc001tko.1_RNA|TXNRD1_uc001tkp.1_RNA|TXNRD1_uc001tkv.1_RNA	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	144	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						CAGGAGGGCAGACTTCAAAAG	0.373													A	104705084	A	A	104705084	3	1	258	1	0	0	0	0	1	0	0	0	16804	942	33	3	463	3	TXNRD1	12	104705084	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	51041395	104705084	29146811	52	18520											
AACS	65985	broad.mit.edu	37	chr12	125609456	125609457	+	Frame_Shift_Del	DEL	CA	-	-													tctgcaccccagtggaaaccCacagtctccagatgctccac							TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr12:125609456_125609457delCA	uc001uhc.2	+	12	1401_1402	c.1195_1196delCA	c.(1195-1197)CACfs	p.H399fs	AACS_uc001uhd.2_Frame_Shift_Del_p.H399fs|AACS_uc009zyh.2_Intron|AACS_uc009zyi.2_5'UTR	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	399					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		AGTGGAAACCCACAGTCTCCAG	0.505													-	125609457	-	-	125609456	7	5	258	1	0	1	0	1	0	0	0	0	9	594	21	0	1241	0	AACS	12	125609456	Frame_Shift_Del	DEL	CA	TCGA-76-4926-01B-01D-1486-08	20904372	125609456	8242439	53	18521											
LRRC57	255252	broad.mit.edu	37	chr15	42836285	42836285	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atagtcctggagaacttcacGcaaacttcttcttggtggct	9	10	3	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr15:42836285G>A	uc001zqd.1	-	5	1084	c.716C>T	c.(715-717)GCG>GTG	p.A239V	LRRC57_uc001zqc.2_Missense_Mutation_p.A239V	NM_153260	NP_694992	Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	239											0		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		AGAACTTCACGCAAACTTCTT	0.408													A	42836285	A	A	42836285	3	1	258	1	0	0	0	0	1	0	0	0	9013	1087	38	1	7	1	LRRC57	15	42836285	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08		42836285	59695107	54	18522											
HMG20A	10363	broad.mit.edu	37	chr15	77771653	77771653	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agttgtgaacagactcgatcGttagggaatggtgagtgctc	14	6	0	3			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr15:77771653G>A	uc002bcr.2	+	10	1241	c.1040G>A	c.(1039-1041)CGT>CAT	p.R347H	HMG20A_uc002bcs.2_Missense_Mutation_p.R347H	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	347					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						AGACTCGATCGTTAGGGAATG	0.368													A	77771653	A	A	77771653	3	1	258	1	0	0	0	0	1	0	0	0	7221	1145	40	1	1070	1	HMG20A	15	77771653	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	34935368	77771653	24759739	55	18523											
TMC3	342125	broad.mit.edu	37	chr15	81627093	81627093	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgctctagcctggatttgggGaccccagggagaggtgagct	16	9	1	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr15:81627093G>A	uc002bgo.1	-	21	2427	c.2427C>T	c.(2425-2427)GTC>GTT	p.V809V	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	809	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						TGGATTTGGGGACCCCAGGGA	0.572													A	81627093	A	A	81627093	2	1	258	1	0	0	0	0	0	0	0	1	15983	1161	41	3		3	TMC3	15	81627093	Silent	SNP	G	TCGA-76-4926-01B-01D-1486-08	3855440	81627093	20904299	56	18524											
OTOA	146183	broad.mit.edu	37	chr16	21716537	21716537	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgacctggaattgctggatgCcactgtggctcaagtcctgc	12	11	1	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr16:21716537C>T	uc002djh.2	+	11	1029	c.1028C>T	c.(1027-1029)GCC>GTC	p.A343V	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.A264V|OTOA_uc002dji.2_Missense_Mutation_p.A19V|OTOA_uc010vbk.1_5'UTR	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	357					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		TTGCTGGATGCCACTGTGGCT	0.512													T	21716537	T	T	21716537	3	4	258	1	0	0	0	0	1	0	0	0	11302	739	26	3	1116	3	OTOA	16	21716537	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08		21716537	68638216	57	18525											
GDPD3	79153	broad.mit.edu	37	chr16	30123709	30123709	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggaacaggtcctccagaCgaaccatgcgccggtctgac	11	14	2	2	rs76435425		TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr16:30123709C>T	uc002dwp.2	-	5	480	c.401G>A	c.(400-402)CGT>CAT	p.R134H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.R72H|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	134	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						GTCCTCCAGACGAACCATGCG	0.602											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	30123709	T	T	30123709	3	4	258	1	0	0	0	0	1	0	0	0	6325	536	19	1	579	1	GDPD3	16	30123709	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	8407172	30123709	60231044	58	18526											
IRF8	3394	broad.mit.edu	37	chr16	85952071	85952071	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctatgggggcaagctggtggGccaggccaccaccacctgcc	14	15	0	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr16:85952071G>A	uc002fjh.2	+	7	707	c.650G>A	c.(649-651)GGC>GAC	p.G217D	IRF8_uc010chp.2_Intron	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	217					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				AAGCTGGTGGGCCAGGCCACC	0.662													A	85952071	A	A	85952071	3	1	258	1	0	0	0	0	1	0	0	0	7836	1203	42	3	672	3	IRF8	16	85952071	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	55828362	85952071	4402682	59	18527											
SPAG5	10615	broad.mit.edu	37	chr17	26907060	26907064	+	Frame_Shift_Del	DEL	GGAAG	-	-													tgctgtcaagatgcttcccaGgaaggtcctgtcattaggca							TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr17:26907060_26907064delGGAAG	uc002hbq.2	-	16	2852_2856	c.2760_2764delCTTCC	c.(2758-2766)ACCTTCCTGfs	p.T920fs	SGK494_uc010waq.1_Frame_Shift_Del_p.T325fs	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	920_922					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					ATGCTTCCCAGGAAGGTCCTGTCAT	0.507													-	26907064	-	-	26907060	7	5	258	1	0	1	0	1	0	0	0	0	14981	991	35	0	853	0	SPAG5	17	26907060	Frame_Shift_Del	DEL	GGAAG	TCGA-76-4926-01B-01D-1486-08		26907060	54288150	60	18528											
MYO18A	399687	broad.mit.edu	37	chr17	27424907	27424907	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccatctgcttcttcagtgcaTcgtactgggtctgcagaaga	10	11	4	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr17:27424907T>C	uc002hdt.1	-	26	4159	c.4001A>G	c.(4000-4002)GAT>GGT	p.D1334G	MYO18A_uc010wbc.1_Missense_Mutation_p.D876G|MYO18A_uc002hds.2_Missense_Mutation_p.D876G|MYO18A_uc010csa.1_Missense_Mutation_p.D1334G|MYO18A_uc002hdu.1_Missense_Mutation_p.D1334G|MYO18A_uc010wbd.1_Missense_Mutation_p.D1003G	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1334	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CTTCAGTGCATCGTACTGGGT	0.542													C	27424907	C	C	27424907	3	2	258	1	0	0	0	0	1	0	0	0	10065	1435	50	4	2231	4	MYO18A	17	27424907	Missense_Mutation	SNP	T	TCGA-76-4926-01B-01D-1486-08	517847	27424907	53770303	61	18529											
ACE	1636	broad.mit.edu	37	chr17	61571327	61571327	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatggcccttgacaagatcGcctttatccccttcagctac	7	14	1	3			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr17:61571327G>A	uc002jau.1	+	21	3203	c.3181G>A	c.(3181-3183)GCC>ACC	p.A1061T	ACE_uc002jav.1_Missense_Mutation_p.A487T|ACE_uc010ddv.1_Missense_Mutation_p.A288T|ACE_uc010wpj.1_Missense_Mutation_p.A487T|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.A307T	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	1061	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TGACAAGATCGCCTTTATCCC	0.552													A	61571327	A	A	61571327	3	1	258	1	0	0	0	0	1	0	0	0	136	1087	38	1	3466	1	ACE	17	61571327	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	34146420	61571327	19623883	62	18530											
PHLPP1	23239	broad.mit.edu	37	chr18	60645528	60645528	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggagtgactgagtccacgCgcatcctgggctacaccttc	11	14	0	2			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr18:60645528C>T	uc002lis.2	+	18	2660	c.2482C>T	c.(2482-2484)CGC>TGC	p.R828C		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1340	PP2C-like.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						TGAGTCCACGCGCATCCTGGG	0.582													T	60645528	T	T	60645528	3	4	258	1	0	0	0	0	1	0	0	0	11854	768	27	1	4084	1	PHLPP1	18	60645528	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08		60645528	17431720	63	18531											
ATP8B3	148229	broad.mit.edu	37	chr19	1795945	1795945	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgaagatgaccgtgtcggCgcccttggtgtacaggcaga	14	10	0	3			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr19:1795945C>T	uc002ltw.2	-	18	2218	c.1984G>A	c.(1984-1986)GCC>ACC	p.A662T	ATP8B3_uc002ltv.2_Missense_Mutation_p.A615T|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	662	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCGTGTCGGCGCCCTTGGTG	0.627											OREG0025127	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	1795945	T	T	1795945	3	4	258	1	0	0	0	0	1	0	0	0	1196	768	27	1	1996	1	ATP8B3	19	1795945	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08		1795945	57333038	64	18532											
MYO9B	4650	broad.mit.edu	37	chr19	17320489	17320489	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagagagtatcgccttcCgcaggctttcgctcctgcga	11	14	0	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr19:17320489C>T	uc010eak.2	+	36	5871	c.5719C>T	c.(5719-5721)CGC>TGC	p.R1907C	MYO9B_uc002nfi.2_Missense_Mutation_p.R1907C|MYO9B_uc002nfj.1_Missense_Mutation_p.R1907C|MYO9B_uc002nfm.1_Missense_Mutation_p.R67C	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1907	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						TATCGCCTTCCGCAGGCTTTC	0.587													T	17320489	T	T	17320489	3	4	258	1	0	0	0	0	1	0	0	0	10085	652	23	2	5857	2	MYO9B	19	17320489	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08	15524544	17320489	41808494	65	18533											
CRTC1	23373	broad.mit.edu	37	chr19	18870986	18870986	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgagcagctccagcagcacCggcaacctcgcggccaacct	10	18	0	1	rs140237275	byFrequency	TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr19:18870986C>T	uc002nkb.3	+	8	922	c.834C>T	c.(832-834)ACC>ACT	p.T278T	CRTC1_uc010ebv.2_Silent_p.T294T|CRTC1_uc010ebw.2_Silent_p.T143T|CRTC1_uc002nkc.3_Silent_p.T143T	NM_015321	NP_056136	Q6UUV9	CRTC1_HUMAN	mucoepidermoid carcinoma translocated 1 isoform	278					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	salivary_gland(474)|lung(35)|thyroid(4)|breast(3)|skin(2)|ovary(1)	519						CCAGCAGCACCGGCAACCTCG	0.697													T	18870986	T	T	18870986	2	4	258	1	0	0	0	0	0	0	0	1	3899	639	23	2		2	CRTC1	19	18870986	Silent	SNP	C	TCGA-76-4926-01B-01D-1486-08	1550497	18870986	40257997	66	18534											
CD177	57126	broad.mit.edu	37	chr19	43859911	43859911	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aggggaccacacactgttatGatggcctcctcaggctcagg	12	12	2	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr19:43859911G>C	uc002owi.2	+	4	520	c.478G>C	c.(478-480)GAT>CAT	p.D160H	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	160	UPAR/Ly6 1.				blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				ACACTGTTATGATGGCCTCCT	0.582													C	43859911	C	C	43859911	3	2	258	1	0	0	0	0	1	0	0	0	2971	1290	45	5	492	5	CD177	19	43859911	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	24988925	43859911	15269072	67	18535											
JAG1	182	broad.mit.edu	37	chr20	10630946	10630946	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggcacacacacttaaatcCgttaaccaggtcctggcagg	11	12	0	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr20:10630946C>T	uc002wnw.2	-	9	1699	c.1183G>A	c.(1183-1185)GGA>AGA	p.G395R	JAG1_uc010gcd.1_5'UTR	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	395	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						CACTTAAATCCGTTAACCAGG	0.463									Alagille_Syndrome				T	10630946	T	T	10630946	3	4	258	1	0	0	0	0	1	0	0	0	7934	661	23	2	2545	2	JAG1	20	10630946	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08		10630946	52394574	68	18536											
CEP250	11190	broad.mit.edu	37	chr20	34067060	34067060	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acattcttcccctcagtcacGtcaccagcaggaggcagcca	8	16	4	0			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr20:34067060G>A	uc002xcm.2	+	19	2770	c.2099G>A	c.(2098-2100)CGT>CAT	p.R700H	CEP250_uc010zve.1_Missense_Mutation_p.R68H	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	700	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CCTCAGTCACGTCACCAGCAG	0.592													A	34067060	A	A	34067060	3	1	258	1	0	0	0	0	1	0	0	0	3252	1145	40	1	2157	1	CEP250	20	34067060	Missense_Mutation	SNP	G	TCGA-76-4926-01B-01D-1486-08	23436114	34067060	28958460	69	18537											
PANX2	56666	broad.mit.edu	37	chr22	50615939	50615939	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgctgggcgcgtccccggaCggggcggcaggtgcggggcc	22	14	0	0	rs35622534		TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chr22:50615939C>T	uc003bjn.3	+	2	798	c.798C>T	c.(796-798)GAC>GAT	p.D266D	PANX2_uc003bjp.3_Silent_p.D132D|PANX2_uc003bjo.3_Silent_p.D266D	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	266	Extracellular (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		CGTCCCCGGACGGGGCGGCAG	0.692													T	50615939	T	T	50615939	2	4	258	1	0	0	0	0	0	0	0	1	11421	535	19	1		1	PANX2	22	50615939	Silent	SNP	C	TCGA-76-4926-01B-01D-1486-08		50615939	688627	70	18538											
MXRA5	25878	broad.mit.edu	37	chrX	3235282	3235282	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggggaggtgcccgtgatgCgcgcgttggctgctgcacgc	19	12	0	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chrX:3235282C>T	uc004crg.3	-	6	6597	c.6440G>A	c.(6439-6441)CGC>CAC	p.R2147H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2147	Ig-like C2-type 6.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCCCGTGATGCGCGCGTTGGC	0.706													T	3235282	T	T	3235282	3	4	258	1	0	0	0	0	1	0	0	0	10003	768	27	1	2054	1	MXRA5	23	3235282	Missense_Mutation	SNP	C	TCGA-76-4926-01B-01D-1486-08		3235282	152035278	71	18539											
ATP11C	286410	broad.mit.edu	37	chrX	138908934	138908934	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtttccgaaactggatgatTgccaacaaacactgtgcgtg	10	9	0	1			TCGA-76-4926-01B-01D-1486-08	TCGA-76-4926-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	3c93cb58-d39b-4a5e-907a-8b5438630d21	ecbd11a3-9ac5-4888-9f28-f5a93f45fe50	g.chrX:138908934T>C	uc004faz.2	-	2	184	c.85A>G	c.(85-87)AAT>GAT	p.N29D	ATP11C_uc004fba.2_Missense_Mutation_p.N29D	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	29	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					ACTGGATGATTGCCAACAAAC	0.373													C	138908934	C	C	138908934	3	2	258	1	0	0	0	0	1	0	0	0	1121	1812	63	4	3492	4	ATP11C	23	138908934	Missense_Mutation	SNP	T	TCGA-76-4926-01B-01D-1486-08	135673652	138908934	16361626	72	18540											
CAMTA1	23261	broad.mit.edu	37	chr1	7797314	7797314	+	Splice_Site	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctgtgtctccctgtcttctaGatgtgggcgtgtgccctagg	13	11	3	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr1:7797314G>A	uc001aoi.2	+	15	3550	c.3343_splice	c.e15-1	p.M1115_splice	CAMTA1_uc010nzv.1_Splice_Site_p.M202_splice|CAMTA1_uc001aok.3_Splice_Site_p.M158_splice|CAMTA1_uc001aoj.2_Splice_Site_p.M71_splice	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CTGTCTTCTAGATGTGGGCGT	0.557													A	7797314	A	A	7797314	5	1	259	1	0	0	0	0	0	0	1	0	2613	956	33	3	3400	3	CAMTA1	1	7797314	Splice_Site	SNP	G	TCGA-76-4927-01A-01D-1486-08		7797314	241453307	1	18541											
GJA8	2703	broad.mit.edu	37	chr1	147380445	147380445	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccagcaggcggggactaaCggcggcccggaccagggcag	19	13	0	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr1:147380445C>T	uc001epu.1	+	2	426	c.363C>T	c.(361-363)AAC>AAT	p.N121N		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	121	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					CGGGGACTAACGGCGGCCCGG	0.657													T	147380445	T	T	147380445	2	4	259	1	0	0	0	0	0	0	0	1	6405	535	19	1		1	GJA8	1	147380445	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08	139583131	147380445	101870176	2	18542											
UBAP2L	9898	broad.mit.edu	37	chr1	154207187	154207187	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagagactatagtcggcgaCgtggtgggccaccaagacgg	15	10	0	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr1:154207187C>T	uc001fep.3	+	5	567	c.400C>T	c.(400-402)CGT>TGT	p.R134C	UBAP2L_uc009wot.2_Missense_Mutation_p.R134C|UBAP2L_uc010pek.1_Missense_Mutation_p.R133C|UBAP2L_uc010pel.1_Missense_Mutation_p.R133C|UBAP2L_uc001fen.1_Missense_Mutation_p.R133C|UBAP2L_uc010pem.1_Missense_Mutation_p.R133C|UBAP2L_uc010pen.1_Missense_Mutation_p.R37C	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	134					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TAGTCGGCGACGTGGTGGGCC	0.552													T	154207187	T	T	154207187	3	4	259	1	0	0	0	0	1	0	0	0	16835	536	19	1	414	1	UBAP2L	1	154207187	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	6826742	154207187	95043434	3	18543											
CACNA1S	779	broad.mit.edu	37	chr1	201058474	201058474	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttgtcgaagtgggtgatgCcatggttgggccctggccag	17	8	0	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr1:201058474C>T	uc001gvv.2	-	6	1039	c.812G>A	c.(811-813)GGC>GAC	p.G271D		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	271	Extracellular (Potential).|I.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GTGGGTGATGCCATGGTTGGG	0.627													T	201058474	T	T	201058474	3	4	259	1	0	0	0	0	1	0	0	0	2547	739	26	3	4965	3	CACNA1S	1	201058474	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	46851287	201058474	48192147	4	18544											
SPATA17	128153	broad.mit.edu	37	chr1	217824518	217824518	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agcaatatcaactaactgtgCaggtaaatataaaatgtaca	6	6	1	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr1:217824518C>A	uc001hlh.1	+	3	264	c.238C>A	c.(238-240)CAG>AAG	p.Q80K	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.Q80K	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	80	IQ 2.					cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		ACTAACTGTGCAGGTAAATAT	0.289													A	217824518	A	A	217824518	3	1	259	1	0	0	0	0	1	0	0	0	15001	711	25	5	248	5	SPATA17	1	217824518	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	16766044	217824518	31426103	5	18545											
DISC1	27185	broad.mit.edu	37	chr1	232144583	232144583	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aagctgacttggaagcttgtCgattgcttatccagagccta	10	9	0	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr1:232144583C>T	uc001huz.2	+	11	2148	c.2095C>T	c.(2095-2097)CGA>TGA	p.R699*	TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pxd.1_Nonsense_Mutation_p.R344*|DISC1_uc010pxe.1_Nonsense_Mutation_p.R699*|DISC1_uc009xfr.2_Nonsense_Mutation_p.R654*|DISC1_uc010pxf.1_Silent_p.V678V|DISC1_uc010pxg.1_3'UTR|DISC1_uc010pxh.1_Nonsense_Mutation_p.R731*|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_Nonsense_Mutation_p.R344*|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Nonsense_Mutation_p.R577*|DISC1_uc010pxn.1_Nonsense_Mutation_p.R344*|DISC1_uc001hva.2_Nonsense_Mutation_p.R699*	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	699	Necessary and sufficient for interaction with PCNT and localization at the centrosome.|Interaction with ATF4 and ATF5.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				GGAAGCTTGTCGATTGCTTAT	0.493													T	232144583	T	T	232144583	4	4	259	1	0	0	0	0	0	1	0	0	4538	876	31	2	2873	2	DISC1	1	232144583	Nonsense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	14320065	232144583	17106038	6	18546											
LPIN1	23175	broad.mit.edu	37	chr2	11911528	11911528	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctatgcacctggccacctccCccatcctgtcagaaggagct	8	17	1	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr2:11911528C>T	uc010yjn.1	+	5	593	c.319C>T	c.(319-321)CCC>TCC	p.P107S	LPIN1_uc010yjm.1_Missense_Mutation_p.P156S|LPIN1_uc002rbt.2_Missense_Mutation_p.P107S|LPIN1_uc002rbs.2_Missense_Mutation_p.P107S	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	107	N-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		GGCCACCTCCCCCATCCTGTC	0.517													T	11911528	T	T	11911528	3	4	259	1	0	0	0	0	1	0	0	0	8918	623	22	3	329	3	LPIN1	2	11911528	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08		11911528	231287845	7	18547											
MFSD2B	388931	broad.mit.edu	37	chr2	24246495	24246495	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgactttcagctgcagcaCcgtcacgggccaggcctgga	13	13	2	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr2:24246495C>T	uc002reo.1	+	12	1226	c.1212C>T	c.(1210-1212)CAC>CAT	p.H404H		NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	404					transport	integral to membrane				ovary(2)	2						AGCTGCAGCACCGTCACGGGC	0.622													T	24246495	T	T	24246495	2	4	259	1	0	0	0	0	0	0	0	1	9531	506	18	3		3	MFSD2B	2	24246495	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08	12334967	24246495	218952878	8	18548											
SCN1A	6323	broad.mit.edu	37	chr2	166897863	166897863	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcaacaaatgggtccatcaCaaccaggttgacaacatgtt	8	10	2	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr2:166897863C>T	uc010zcz.1	-	13	2278	c.2260G>A	c.(2260-2262)GTG>ATG	p.V754M	SCN1A_uc002udo.3_Missense_Mutation_p.V634M|SCN1A_uc010fpk.2_Missense_Mutation_p.V606M	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	765	Helical; Name=S1 of repeat II; (By similarity).|II.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGGTCCATCACAACCAGGTTG	0.403													T	166897863	T	T	166897863	3	4	259	1	0	0	0	0	1	0	0	0	13914	478	17	3	3792	3	SCN1A	2	166897863	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	142651368	166897863	76301510	9	18549											
PIKFYVE	200576	broad.mit.edu	37	chr2	209150648	209150648	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atttttagaggatgatttggCctggcaaaggtattgtccct	11	6	0	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr2:209150648C>T	uc002vcz.2	+	6	970	c.812C>T	c.(811-813)GCC>GTC	p.A271V	PIKFYVE_uc010fun.1_5'UTR|PIKFYVE_uc002vcy.1_Missense_Mutation_p.A271V|PIKFYVE_uc002vcv.2_Missense_Mutation_p.A174V|PIKFYVE_uc002vcw.2_Missense_Mutation_p.A271V|PIKFYVE_uc002vcx.2_Missense_Mutation_p.A185V	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	271					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GATGATTTGGCCTGGCAAAGG	0.403													T	209150648	T	T	209150648	3	4	259	1	0	0	0	0	1	0	0	0	11924	739	26	3	830	3	PIKFYVE	2	209150648	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	42252785	209150648	34048725	10	18550											
TNS1	7145	broad.mit.edu	37	chr2	218713141	218713141	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggagggccgcatgggggccGtgtggccagcatgggcaggc	21	10	0	0	rs147452506		TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr2:218713141G>A	uc002vgt.2	-	17	2122	c.1724C>T	c.(1723-1725)ACG>ATG	p.T575M	TNS1_uc002vgr.2_Missense_Mutation_p.T575M|TNS1_uc002vgs.2_Missense_Mutation_p.T575M|TNS1_uc010zjv.1_Missense_Mutation_p.T575M|TNS1_uc010fvj.1_Missense_Mutation_p.T643M|TNS1_uc010fvk.1_Missense_Mutation_p.T700M|TNS1_uc010fvi.1_Missense_Mutation_p.T262M	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	575						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CATGGGGGCCGTGTGGCCAGC	0.667													A	218713141	A	A	218713141	3	1	259	1	0	0	0	0	1	0	0	0	16340	1145	40	1	3551	1	TNS1	2	218713141	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	9562493	218713141	24486232	11	18551											
COL6A3	1293	broad.mit.edu	37	chr2	238303590	238303590	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttctaatccttttccagtctGattggttcccccaatataag	5	11	2	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr2:238303590G>C	uc002vwl.2	-	3	634	c.349C>G	c.(349-351)CAG>GAG	p.Q117E	COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Intron|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Missense_Mutation_p.Q117E	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	117	VWFA 1.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTTCCAGTCTGATTGGTTCCC	0.453													C	238303590	C	C	238303590	3	2	259	1	0	0	0	0	1	0	0	0	3701	1299	45	5	9399	5	COL6A3	2	238303590	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	19590449	238303590	4895783	12	18552											
HDAC4	9759	broad.mit.edu	37	chr2	240061423	240061423	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgggcgcgataccgttctccGcgctgacgctcccggagctg	14	16	1	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr2:240061423G>A	uc002vyk.3	-	9	1727	c.935C>T	c.(934-936)GCG>GTG	p.A312V	HDAC4_uc010fyz.1_Missense_Mutation_p.A307V|HDAC4_uc010zoa.1_Missense_Mutation_p.A307V|HDAC4_uc010fza.2_Missense_Mutation_p.A312V|HDAC4_uc010fyy.2_Missense_Mutation_p.A264V|HDAC4_uc010znz.1_Missense_Mutation_p.A195V|HDAC4_uc010fzb.1_RNA	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	312	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		ACCGTTCTCCGCGCTGACGCT	0.662													A	240061423	A	A	240061423	3	1	259	1	0	0	0	0	1	0	0	0	7009	1087	38	1	2395	1	HDAC4	2	240061423	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	1757833	240061423	3137950	13	18553											
FGD5	152273	broad.mit.edu	37	chr3	14862435	14862435	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtcgacatcccacctcctttCgacctggcctgcatcaccaa	6	18	1	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr3:14862435C>T	uc003bzc.2	+	1	1967	c.1857C>T	c.(1855-1857)TTC>TTT	p.F619F	FGD5_uc011avk.1_Silent_p.F619F	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	619					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CACCTCCTTTCGACCTGGCCT	0.557													T	14862435	T	T	14862435	2	4	259	1	0	0	0	0	0	0	0	1	5836	883	31	2		2	FGD5	3	14862435	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08		14862435	183159995	14	18554											
SLC6A20	54716	broad.mit.edu	37	chr3	45812818	45812818	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatgagggacacgatgatggCgtgcttctggcagttgttgg	17	6	1	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr3:45812818C>T	uc011bai.1	-	6	950	c.826G>A	c.(826-828)GCC>ACC	p.A276T	SLC6A20_uc003cow.2_5'UTR|SLC6A20_uc011baj.1_Missense_Mutation_p.A239T	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	276	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		ACGATGATGGCGTGCTTCTGG	0.517													T	45812818	T	T	45812818	3	4	259	1	0	0	0	0	1	0	0	0	14684	768	27	1	976	1	SLC6A20	3	45812818	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	30950383	45812818	152209612	15	18555											
PHLDB2	90102	broad.mit.edu	37	chr3	111603533	111603533	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggagccgcaagcatgccttcAagcccaaagcaagccaggaa	11	13	1	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr3:111603533A>C	uc010hqa.2	+	2	1020	c.609A>C	c.(607-609)TCA>TCC	p.S203S	PHLDB2_uc003dyc.2_Silent_p.S230S|PHLDB2_uc003dyd.2_Silent_p.S203S|PHLDB2_uc003dyg.2_Silent_p.S203S|PHLDB2_uc003dyh.2_Silent_p.S203S|PHLDB2_uc003dye.3_Silent_p.S203S|PHLDB2_uc003dyf.3_Silent_p.S203S	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	203						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GCATGCCTTCAAGCCCAAAGC	0.532													C	111603533	C	C	111603533	2	2	259	1	0	0	0	0	0	0	0	1	11852	117	5	5		5	PHLDB2	3	111603533	Silent	SNP	A	TCGA-76-4927-01A-01D-1486-08	65790715	111603533	86418897	16	18556											
FIP1L1	81608	broad.mit.edu	37	chr4	54294195	54294195	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aactgtgctctaattttaggTcctttctgaaagatctgcta	7	8	3	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr4:54294195T>C	uc003gzy.2	+	13	1205	c.1019T>C	c.(1018-1020)GTC>GCC	p.V340A	PDGFRA_uc003haa.2_Intron|FIP1L1_uc003gzx.3_Missense_Mutation_p.V325A|FIP1L1_uc011bzt.1_Missense_Mutation_p.V304A|FIP1L1_uc011bzu.1_Missense_Mutation_p.V325A|FIP1L1_uc003gzz.2_Missense_Mutation_p.V266A|FIP1L1_uc003hab.2_Missense_Mutation_p.V305A|FIP1L1_uc003hac.2_Missense_Mutation_p.V85A|FIP1L1_uc010ign.2_RNA|FIP1L1_uc003had.2_5'UTR|FIP1L1_uc003hae.2_5'UTR	NM_030917	NP_112179	Q6UN15	FIP1_HUMAN	FIP1 like 1 isoform 1	340	Necessary for stimulating PAPOLA activity.	Breakpoint for interstitial deletion to form the FIP1L1-PDGFRA fusion protein.			mRNA processing	nucleus	RNA binding			ovary(1)|skin(1)	2			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TAATTTTAGGTCCTTTCTGAA	0.264			T	PDGFRA	idiopathic hypereosinophilic syndrome								C	54294195	C	C	54294195	3	2	259	1	0	0	0	0	1	0	0	0	5896	1681	58	4	1069	4	FIP1L1	4	54294195	Missense_Mutation	SNP	T	TCGA-76-4927-01A-01D-1486-08		54294195	136860081	17	18557											
ANKRD56	345079	broad.mit.edu	37	chr4	77818025	77818025	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctggcagcaccgaccaggcGcggatagggccctgatcacg	14	14	2	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr4:77818025G>A	uc003hki.2	-	1	978	c.978C>T	c.(976-978)CGC>CGT	p.R326R		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	326											0						CCGACCAGGCGCGGATAGGGC	0.657													A	77818025	A	A	77818025	2	1	259	1	0	0	0	0	0	0	0	1	682	1074	38	1		1	ANKRD56	4	77818025	Silent	SNP	G	TCGA-76-4927-01A-01D-1486-08	23523830	77818025	113336251	18	18558											
TLR2	7097	broad.mit.edu	37	chr4	154625003	154625003	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtggaaacgttaacaatccGgaggctgcatattccaaggt	11	8	0	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr4:154625003G>A	uc003inq.2	+	3	1163	c.944G>A	c.(943-945)CGG>CAG	p.R315Q	TLR2_uc003inr.2_Missense_Mutation_p.R315Q|TLR2_uc003ins.2_Missense_Mutation_p.R315Q	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	315	Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				TTAACAATCCGGAGGCTGCAT	0.338													A	154625003	A	A	154625003	3	1	259	1	0	0	0	0	1	0	0	0	15948	1116	39	2	946	2	TLR2	4	154625003	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	76806978	154625003	36529273	19	18559											
PLEKHG4B	153478	broad.mit.edu	37	chr5	163559	163559	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacagagaagaagctcccGctgtggcagcatgccaggag	14	12	0	2	rs114260538	byFrequency	TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr5:163559G>A	uc003jak.2	+	11	2354	c.2304G>A	c.(2302-2304)CCG>CCA	p.P768P		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	768					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGAAGCTCCCGCTGTGGCAGC	0.652													A	163559	A	A	163559	2	1	259	1	0	0	0	0	0	0	0	1	12072	1074	38	1		1	PLEKHG4B	5	163559	Silent	SNP	G	TCGA-76-4927-01A-01D-1486-08		163559	180751701	20	18560											
PIK3R1	5295	broad.mit.edu	37	chr5	67575431	67575432	+	Frame_Shift_Ins	INS	-	A	A													tcttaaattgtttcctagatINSacaccctccgtggacttgga							TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr5:67575431_67575432insA	uc003jva.2	+	5	1064_1065	c.504_505insA	c.(502-507)GATACAfs	p.D168fs	PIK3R1_uc003jvb.2_Frame_Shift_Ins_p.D168fs	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	168_169	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GTTTCCTAGATACACCCTCCGT	0.381			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			A	67575432	A	A	67575431	7	5	259	1	0	1	1	0	0	0	0	0	11918	1420	49	0	518	0	PIK3R1	5	67575431	Frame_Shift_Ins	INS	-	TCGA-76-4927-01A-01D-1486-08	67411872	67575431	113339829	21	18561											
PCDHA5	56143	broad.mit.edu	37	chr5	140202723	140202723	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgacaacgctccggcgttcGcgcagccccagtataccgtg	11	16	0	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr5:140202723G>A	uc003lhl.2	+	1	1363	c.1363G>A	c.(1363-1365)GCG>ACG	p.A455T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.A455T|PCDHA5_uc003lhj.1_Missense_Mutation_p.A455T	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	455	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCGGCGTTCGCGCAGCCCCA	0.677													A	140202723	A	A	140202723	3	1	259	1	0	0	0	0	1	0	0	0	11527	1087	38	1	1365	1	PCDHA5	5	140202723	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	72627292	140202723	40712537	22	18562											
GPR111	222611	broad.mit.edu	37	chr6	47647995	47647995	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attgtgcagctcttacacaaCatatcaacagcaatatggac	6	10	2	0	rs141145040	by1000genomes	TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr6:47647995C>A	uc010jzj.1	+	5	661	c.660C>A	c.(658-660)AAC>AAA	p.N220K	GPR111_uc010jzk.1_Missense_Mutation_p.N152K|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	220	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						TCTTACACAACATATCAACAG	0.438													A	47647995	A	A	47647995	3	1	259	1	0	0	0	0	1	0	0	0	6628	477	17	5	470	5	GPR111	6	47647995	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08		47647995	123467072	23	18563											
PACRG	135138	broad.mit.edu	37	chr6	163510341	163510341	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgtgtcactctcaaggtcCtccagcatctggttgtgtca	9	12	5	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr6:163510341C>T	uc003qua.2	+	5	738	c.514C>T	c.(514-516)CTC>TTC	p.L172F	PACRG_uc003qub.2_Missense_Mutation_p.L172F|PACRG_uc003quc.2_Missense_Mutation_p.L172F	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	172											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		TCTCAAGGTCCTCCAGCATCT	0.448													T	163510341	T	T	163510341	3	4	259	1	0	0	0	0	1	0	0	0	11370	681	24	3	528	3	PACRG	6	163510341	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	115862346	163510341	7604726	24	18564											
INTS1	26173	broad.mit.edu	37	chr7	1522258	1522258	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaagcagcagcgcctcctcCgatgtgtccaccaggaaggc	13	14	0	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr7:1522258C>T	uc003skn.2	-	27	3728	c.3627G>A	c.(3625-3627)TCG>TCA	p.S1209S	INTS1_uc003skp.1_3'UTR	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1209					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCGCCTCCTCCGATGTGTCCA	0.642													T	1522258	T	T	1522258	2	4	259	1	0	0	0	0	0	0	0	1	7775	639	23	2		2	INTS1	7	1522258	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08		1522258	157616405	25	18565											
TXNDC3	51314	broad.mit.edu	37	chr7	37890338	37890338	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaattctgcattttgctgtcGtaagaattttgttttcatta	6	5	2	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr7:37890338G>A	uc003tfn.2	+	5	570	c.198_splice	c.e5+1	p.V66_splice		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3						cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TTTTGCTGTCGTAAGAATTTT	0.318									Kartagener_syndrome				A	37890338	A	A	37890338	5	1	259	1	0	0	0	0	0	0	1	0	16795	1159	40	1	209	1	TXNDC3	7	37890338	Splice_Site	SNP	G	TCGA-76-4927-01A-01D-1486-08	36368080	37890338	121248325	26	18566											
TXNDC3	51314	broad.mit.edu	37	chr7	37924770	37924770	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tccatctctagcccttgtttTattgagagacaatggcttgc	8	10	1	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr7:37924770T>A	uc003tfn.2	+	14	1535	c.1163T>A	c.(1162-1164)TTA>TAA	p.L388*		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	388	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GCCCTTGTTTTATTGAGAGAC	0.368									Kartagener_syndrome				A	37924770	A	A	37924770	4	1	259	1	0	0	0	0	0	1	0	0	16795	1764	61	5	1209	5	TXNDC3	7	37924770	Nonsense_Mutation	SNP	T	TCGA-76-4927-01A-01D-1486-08	34432	37924770	121213893	27	18567											
PKD1L1	168507	broad.mit.edu	37	chr7	47854942	47854942	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaagctcacctgagcccccGgcacacgggctgacggggtg	15	14	1	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr7:47854942G>A	uc003tny.1	-	47	7079	c.7079C>T	c.(7078-7080)CCG>CTG	p.P2360L	C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_Missense_Mutation_p.P87L	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2360	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CTGAGCCCCCGGCACACGGGC	0.567													A	47854942	A	A	47854942	3	1	259	1	0	0	0	0	1	0	0	0	11964	1116	39	2	1514	2	PKD1L1	7	47854942	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	9930172	47854942	111283721	28	18568											
EGFR	1956	broad.mit.edu	37	chr7	55220274	55220274	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcccagcagtgctccgggCgctgccgtggcaagtccccc	14	17	0	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr7:55220274C>T	uc003tqk.2	+	6	910	c.664C>T	c.(664-666)CGC>TGC	p.R222C	EGFR_uc003tqh.2_Missense_Mutation_p.R222C|EGFR_uc003tqi.2_Missense_Mutation_p.R222C|EGFR_uc003tqj.2_Missense_Mutation_p.R222C|EGFR_uc010kzg.1_Missense_Mutation_p.R177C|EGFR_uc011kco.1_Missense_Mutation_p.R169C|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	222	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.R222C(2)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGCTCCGGGCGCTGCCGTGG	0.597		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55220274	T	T	55220274	3	4	259	1	0	0	0	0	1	0	0	0	4967	768	27	1	686	1	EGFR	7	55220274	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	7365332	55220274	103918389	29	18569											
TAC1	6863	broad.mit.edu	37	chr7	97364145	97364145	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctttcttctaggacatggCcagatctctcacaaaagtaa	6	10	5	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr7:97364145C>T	uc003uop.3	+	5	519	c.273C>T	c.(271-273)GGC>GGT	p.G91G	TAC1_uc003uoq.3_Silent_p.G91G|TAC1_uc003uor.3_Silent_p.G76G|TAC1_uc003uos.3_Silent_p.G76G	NM_003182	NP_003173	P20366	TKN1_HUMAN	tachykinin 1 isoform beta precursor	91					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space					0	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	TAGGACATGGCCAGATCTCTC	0.214													T	97364145	T	T	97364145	2	4	259	1	0	0	0	0	0	0	0	1	15495	726	26	3		3	TAC1	7	97364145	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08	42143871	97364145	61774518	30	18570											
FAM71F1	84691	broad.mit.edu	37	chr7	128369997	128369997	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	acagcatcccttgcacctgtGacctacgttggagggcttca	10	13	1	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr7:128369997G>A	uc003vno.1	+	6	948	c.895G>A	c.(895-897)GAC>AAC	p.D299N	FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.D198N|FAM71F1_uc003vnp.1_Missense_Mutation_p.D297N	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	299								p.D299G(1)		skin(1)	1						TTGCACCTGTGACCTACGTTG	0.532													A	128369997	A	A	128369997	3	1	259	1	0	0	0	0	1	0	0	0	5612	1290	45	3	917	3	FAM71F1	7	128369997	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	31005852	128369997	30768666	31	18571											
LMBR1	64327	broad.mit.edu	37	chr7	156556439	156556439	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actatcccaagaatgagtaaCgcaagaagaagaagcatgac	9	8	0	6			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr7:156556439C>T	uc003wmw.3	-	6	689	c.474G>A	c.(472-474)GCG>GCA	p.A158A	LMBR1_uc003wmv.3_Silent_p.A6A|LMBR1_uc003wmx.3_Silent_p.A6A|LMBR1_uc010lqn.2_Silent_p.A158A|LMBR1_uc011kvx.1_Silent_p.A137A	NM_022458	NP_071903	Q8WVP7	LMBR1_HUMAN	limb region 1 protein	158	Helical; (Potential).					integral to membrane	receptor activity				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		GAATGAGTAACGCAAGAAGAA	0.378													T	156556439	T	T	156556439	2	4	259	1	0	0	0	0	0	0	0	1	8840	523	19	1		1	LMBR1	7	156556439	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08	28186442	156556439	2582224	32	18572											
UBXN8	7993	broad.mit.edu	37	chr8	30609013	30609013	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcatggcttaactcatttaaAtctccccaagtttatctgaa	4	10	4	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr8:30609013A>C	uc003xii.2	+	2	206	c.189A>C	c.(187-189)AAA>AAC	p.K63N	UBXN8_uc010lvi.2_Intron|UBXN8_uc011lbb.1_RNA|UBXN8_uc003xij.2_RNA	NM_005671	NP_005662	O00124	UBXN8_HUMAN	reproduction 8	63					single fertilization						0						ACTCATTTAAATCTCCCCAAG	0.338													C	30609013	C	C	30609013	3	2	259	1	0	0	0	0	1	0	0	0	16916	98	4	5	195	5	UBXN8	8	30609013	Missense_Mutation	SNP	A	TCGA-76-4927-01A-01D-1486-08		30609013	115755009	33	18573											
TG	7038	broad.mit.edu	37	chr8	134107432	134107432	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagaagcctgccaatgtcCtcaatgatgcccagaccaag	9	14	1	3			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr8:134107432C>T	uc003ytw.2	+	42	7425	c.7384C>T	c.(7384-7386)CTC>TTC	p.L2462F	TG_uc010mdw.2_Missense_Mutation_p.L1221F|TG_uc011ljb.1_Missense_Mutation_p.L831F|TG_uc011ljc.1_Missense_Mutation_p.L595F|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2462					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGCCAATGTCCTCAATGATGC	0.448													T	134107432	T	T	134107432	3	4	259	1	0	0	0	0	1	0	0	0	15810	681	24	3	7550	3	TG	8	134107432	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	103498419	134107432	12256590	34	18574											
CTSL2	1515	broad.mit.edu	37	chr9	99800218	99800218	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	accgcgccatataatcttctGtgtgttgccttccactggta	8	12	2	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr9:99800218G>C	uc004awt.2	-	2	305	c.108C>G	c.(106-108)CAC>CAG	p.H36Q	CTSL2_uc010msi.2_Missense_Mutation_p.H36Q|CTSL2_uc004awu.2_5'UTR|CTSL2_uc010msj.1_5'UTR|CTSL2_uc010msk.2_5'UTR	NM_001333	NP_001324	O60911	CATL2_HUMAN	cathepsin L2 preproprotein	36						lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(62;0.0559)				ATAATCTTCTGTGTGTTGCCT	0.483													C	99800218	C	C	99800218	3	2	259	1	0	0	0	0	1	0	0	0	4039	1368	48	5	924	5	CTSL2	9	99800218	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08		99800218	41413213	35	18575											
FAM102A	399665	broad.mit.edu	37	chr9	130710496	130710496	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tggagatggacttggcagtcGatggtggccttgggaagaca	17	6	0	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr9:130710496G>A	uc004bsx.1	-	6	549	c.470C>T	c.(469-471)TCG>TTG	p.S157L	FAM102A_uc004bsw.1_Missense_Mutation_p.S15L|FAM102A_uc004bsy.1_5'UTR	NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	157	Ser-rich.									ovary(1)	1						CTTGGCAGTCGATGGTGGCCT	0.602													A	130710496	A	A	130710496	3	1	259	1	0	0	0	0	1	0	0	0	5382	1059	37	2	708	2	FAM102A	9	130710496	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	30910278	130710496	10502935	36	18576											
PTEN	5728	broad.mit.edu	37	chr10	89692905	89692905	+	Frame_Shift_Del	DEL	G	-	-													ctgtaaagctggaaagggacGaactggtgtaatgatatgtg					rs121913292		TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr10:89692905delG	uc001kfb.2	+	6	1420	c.389delG	c.(388-390)CGAfs	p.R130fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	130	Phosphatase tensin-type.		R -> L (in CD and endometrial hyperplasia; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> Q (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|R -> G (loss of phosphatase activity towards Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3).	R->M: Does not affect the ability to inhibit AKT/PKB activation.	activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R130G(65)|p.R130*(61)|p.R130Q(43)|p.R130fs*4(12)|p.R130L(7)|p.R55fs*1(4)|p.R130P(4)|p.K128_R130del(3)|p.Y27_N212>Y(2)|p.?(2)|p.Y27fs*1(2)|p.R130R(1)|p.K128fs*47(1)|p.A121_F145del(1)|p.R130fs*2(1)|p.T131fs*50(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGAAAGGGACGAACTGGTGTA	0.403	R130Q(MDAPCA2B_PROSTATE)|R130Q(MFE296_ENDOMETRIUM)|R130fs*4(AN3CA_ENDOMETRIUM)|R130Q(JHUEM1_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89692905	-	-	89692905	7	5	259	1	0	1	0	1	0	0	0	0	12738	1058	37	0	407	0	PTEN	10	89692905	Frame_Shift_Del	DEL	G	TCGA-76-4927-01A-01D-1486-08		89692905	45841842	37	18577											
MUC5B	727897	broad.mit.edu	37	chr11	1263896	1263896	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacggccaccccgacctccaCcctgagaacagctccccctc	6	23	0	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr11:1263896C>T	uc009ycr.1	+	47	7991	c.7865C>T	c.(7864-7866)ACC>ATC	p.T2622I	MUC5B_uc001ltb.2_Missense_Mutation_p.T1932I	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1929	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCGACCTCCACCCTGAGAACA	0.637													T	1263896	T	T	1263896	3	4	259	1	0	0	0	0	1	0	0	0	9979	507	18	3	5917	3	MUC5B	11	1263896	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08		1263896	133742620	38	18578											
OR52N1	79473	broad.mit.edu	37	chr11	5809803	5809803	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccacaatatgaagagagtgtTgggaagggtgctggtgcaca	15	6	0	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr11:5809803T>C	uc010qzo.1	-	1	244	c.244A>G	c.(244-246)AAC>GAC	p.N82D	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		AAGAGAGTGTTGGGAAGGGTG	0.473													C	5809803	C	C	5809803	3	2	259	1	0	0	0	0	1	0	0	0	11127	1812	63	4	721	4	OR52N1	11	5809803	Missense_Mutation	SNP	T	TCGA-76-4927-01A-01D-1486-08	4545907	5809803	129196713	39	18579											
NPAS4	266743	broad.mit.edu	37	chr11	66189954	66189954	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcccagggtgacagcatctaCgacatcattgacccagctga	10	13	2	3			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr11:66189954C>T	uc001ohx.1	+	3	536	c.360C>T	c.(358-360)TAC>TAT	p.Y120Y	NPAS4_uc010rpc.1_Translation_Start_Site	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	120	PAS 1.				transcription, DNA-dependent		DNA binding|signal transducer activity				0						ACAGCATCTACGACATCATTG	0.557													T	66189954	T	T	66189954	2	4	259	1	0	0	0	0	0	0	0	1	10565	547	19	1		1	NPAS4	11	66189954	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08	60380151	66189954	68816562	40	18580											
PRCP	5547	broad.mit.edu	37	chr11	82549612	82549612	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggcatgactacttctgtgCaggcctaagaagcaaaccaa	10	10	1	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr11:82549612C>T	uc001ozs.2	-	8	1204	c.1091G>A	c.(1090-1092)TGC>TAC	p.C364Y	PRCP_uc001ozr.2_Missense_Mutation_p.C385Y	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	364					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						TACTTCTGTGCAGGCCTAAGA	0.274													T	82549612	T	T	82549612	3	4	259	1	0	0	0	0	1	0	0	0	12449	710	25	3	407	3	PRCP	11	82549612	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	16359658	82549612	52456904	41	18581											
KITLG	4254	broad.mit.edu	37	chr12	88939597	88939597	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cccttcagttttgacgagagGattaaataggagcagctgaa	11	7	1	3			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr12:88939597G>C	uc001tav.2	-	2	244	c.61C>G	c.(61-63)CCT>GCT	p.P21A	KITLG_uc001taw.2_Missense_Mutation_p.P21A	NM_000899	NP_000890	P21583	SCF_HUMAN	KIT ligand isoform b precursor	21					cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			ovary(1)	1						TTGACGAGAGGATTAAATAGG	0.363									Testicular_Cancer_Familial_Clustering_of				C	88939597	C	C	88939597	3	2	259	1	0	0	0	0	1	0	0	0	8330	1174	41	5	792	5	KITLG	12	88939597	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08		88939597	44912298	42	18582											
TXNRD1	7296	broad.mit.edu	37	chr12	104721416	104721416	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atccaggcaggaagattgctGgctcagaggctctatgcagg	14	9	2	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr12:104721416G>A	uc010swk.1	+	13	1531	c.1509G>A	c.(1507-1509)CTG>CTA	p.L503L	TXNRD1_uc010swl.1_Silent_p.L353L|TXNRD1_uc010swm.1_Silent_p.L405L|TXNRD1_uc010swn.1_Silent_p.L353L|TXNRD1_uc010swo.1_Silent_p.L353L|TXNRD1_uc010swp.1_Silent_p.L315L|TXNRD1_uc010swq.1_Silent_p.L403L|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Silent_p.L419L	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	503					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						GAAGATTGCTGGCTCAGAGGC	0.473													A	104721416	A	A	104721416	2	1	259	1	0	0	0	0	0	0	0	1	16804	1335	47	3		3	TXNRD1	12	104721416	Silent	SNP	G	TCGA-76-4927-01A-01D-1486-08	15781819	104721416	29130479	43	18583											
SCFD1	23256	broad.mit.edu	37	chr14	31142541	31142541	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaagatgaggtcaaacgactTaaaagcattatggtaagatt	10	4	1	3			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr14:31142541T>C	uc001wqm.1	+	12	1098	c.1074T>C	c.(1072-1074)CTT>CTC	p.L358L	SCFD1_uc001wqn.1_Silent_p.L291L|SCFD1_uc010tpg.1_Silent_p.L299L|SCFD1_uc010tph.1_Silent_p.L173L|SCFD1_uc010amf.1_Silent_p.L173L|SCFD1_uc010tpi.1_Silent_p.L266L|SCFD1_uc010amd.1_Silent_p.L190L|SCFD1_uc010ame.1_Silent_p.L291L	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	358					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		TCAAACGACTTAAAAGCATTA	0.338													C	31142541	C	C	31142541	2	2	259	1	0	0	0	0	0	0	0	1	13889	1741	61	4		4	SCFD1	14	31142541	Silent	SNP	T	TCGA-76-4927-01A-01D-1486-08		31142541	76206999	44	18584											
ESR2	2100	broad.mit.edu	37	chr14	64749369	64749369	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caggtaaggtgtgttctagcGatcttgcttcacaccaggga	12	9	3	0	rs141516067		TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr14:64749369G>A	uc001xha.1	-	2	803	c.335C>T	c.(334-336)TCG>TTG	p.S112L	ESR2_uc001xgu.2_Missense_Mutation_p.S112L|ESR2_uc001xgv.2_Missense_Mutation_p.S112L|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Missense_Mutation_p.S112L|ESR2_uc001xgy.1_Missense_Mutation_p.S112L|ESR2_uc001xgz.1_Missense_Mutation_p.S112L|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Missense_Mutation_p.S112L	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	112	Modulating.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	GTGTTCTAGCGATCTTGCTTC	0.448													A	64749369	A	A	64749369	3	1	259	1	0	0	0	0	1	0	0	0	5257	1059	37	2	1375	2	ESR2	14	64749369	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	33606828	64749369	42600171	45	18585											
PAPLN	89932	broad.mit.edu	37	chr14	73729314	73729314	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcggcagcagtcctgcaggCgagcaggaacccagccagca	15	14	0	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr14:73729314C>T	uc010ttx.1	+	18	2665	c.2502C>T	c.(2500-2502)GGC>GGT	p.G834G	PAPLN_uc001xnw.3_Silent_p.G807G|PAPLN_uc010arl.2_Intron|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Silent_p.G818G|PAPLN_uc010arm.2_Missense_Mutation_p.A26V|PAPLN_uc010arn.2_Silent_p.G34G	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	834						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GTCCTGCAGGCGAGCAGGAAC	0.682													T	73729314	T	T	73729314	2	4	259	1	0	0	0	0	0	0	0	1	11428	755	27	1		1	PAPLN	14	73729314	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08	8979945	73729314	33620226	46	18586											
GPR68	8111	broad.mit.edu	37	chr14	91700886	91700886	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtagtgctcaaagcacacgCggtgctggttctcgtcctcg	13	12	2	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr14:91700886C>T	uc001xzg.2	-	2	850	c.509G>A	c.(508-510)CGC>CAC	p.R170H	GPR68_uc001xzh.2_Missense_Mutation_p.R180H	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	170	Extracellular (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		AAAGCACACGCGGTGCTGGTT	0.627													T	91700886	T	T	91700886	3	4	259	1	0	0	0	0	1	0	0	0	6707	768	27	1	592	1	GPR68	14	91700886	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	17971572	91700886	15648654	47	18587											
BDKRB1	623	broad.mit.edu	37	chr14	96730468	96730468	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggccagccggaggcagcagcGgcggaggcaggcccgggtca	20	13	1	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr14:96730468G>A	uc001yfh.2	+	3	657	c.449G>A	c.(448-450)CGG>CAG	p.R150Q	BDKRB1_uc010avn.2_Missense_Mutation_p.R150Q	NM_000710	NP_000701	P46663	BKRB1_HUMAN	bradykinin receptor B1	150	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			ovary(3)	3		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		AGGCAGCAGCGGCGGAGGCAG	0.632													A	96730468	A	A	96730468	3	1	259	1	0	0	0	0	1	0	0	0	1392	1116	39	2	451	2	BDKRB1	14	96730468	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	5029582	96730468	10619072	48	18588											
MKRN3	7681	broad.mit.edu	37	chr15	23811282	23811282	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gggggagaactgtcgctattCgcacgacctttctggtcgga	14	10	1	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr15:23811282C>T	uc001ywh.3	+	1	829	c.353C>T	c.(352-354)TCG>TTG	p.S118L	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.S118L	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	118	C3H1-type 1.					ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TGTCGCTATTCGCACGACCTT	0.597													T	23811282	T	T	23811282	3	4	259	1	0	0	0	0	1	0	0	0	9608	893	31	2	355	2	MKRN3	15	23811282	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08		23811282	78720110	49	18589											
ANKS3	124401	broad.mit.edu	37	chr16	4764084	4764084	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggctcttgggcagagagGgcgagtaagtgtccatcaag	16	7	2	2	rs146798732		TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr16:4764084G>A	uc002cxj.1	-	7	972	c.677C>T	c.(676-678)CCC>CTC	p.P226L	ANKS3_uc002cxi.1_Missense_Mutation_p.P153L|ANKS3_uc002cxk.2_Missense_Mutation_p.P97L|ANKS3_uc002cxl.2_Missense_Mutation_p.P53L|ANKS3_uc010uxs.1_Missense_Mutation_p.P153L|ANKS3_uc002cxm.2_Missense_Mutation_p.P20L	NM_133450	NP_597707	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain	226											0						GGGCAGAGAGGGCGAGTAAGT	0.617													A	4764084	A	A	4764084	3	1	259	1	0	0	0	0	1	0	0	0	690	1232	43	3	1337	3	ANKS3	16	4764084	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08		4764084	85590669	50	18590											
HAS3	3038	broad.mit.edu	37	chr16	69148326	69148326	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcaacgtggagcgggcctgCcagtcctactttggctgtgt	13	11	1	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr16:69148326C>T	uc010cfh.2	+	4	1043	c.819C>T	c.(817-819)TGC>TGT	p.C273C	HAS3_uc002ewk.2_Intron|HAS3_uc002ewl.2_Silent_p.C273C	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	273	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		AGCGGGCCTGCCAGTCCTACT	0.552													T	69148326	T	T	69148326	2	4	259	1	0	0	0	0	0	0	0	1	6963	747	26	3		3	HAS3	16	69148326	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08	64384242	69148326	21206427	51	18591											
KRTAP4-4	84616	broad.mit.edu	37	chr17	39316492	39316492	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gcctgtagcacctggacacaCagcagctggggcggcagcag	15	13	0	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr17:39316492C>G	uc002hwc.2	-	1	492	c.452G>C	c.(451-453)TGT>TCT	p.C151S		NM_032524	NP_115913	Q9BYR3	KRA44_HUMAN	keratin associated protein 4.4	151	26.|26 X 5 AA repeats of C-C-[GRQVCH]-[SPT]- [VSTQR].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			CCTGGACACACAGCAGCTGGG	0.642													G	39316492	G	G	39316492	3	3	259	1	0	0	0	0	1	0	0	0	8553	478	17	5	52	5	KRTAP4-4	17	39316492	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08		39316492	41878718	52	18592											
BRCA1	672	broad.mit.edu	37	chr17	41244612	41244612	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggaaaaagtggtggtataCgatatgggttttgtaaaagt	14	1	0	0	rs80356985		TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr17:41244612C>T	uc002icq.2	-	10	3168	c.2936G>A	c.(2935-2937)CGT>CAT	p.R979H	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.R908H|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.R932H|BRCA1_uc002ict.2_Missense_Mutation_p.R979H|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.R979H|BRCA1_uc002ide.1_Missense_Mutation_p.R810H|BRCA1_uc010cyy.1_Missense_Mutation_p.R979H|BRCA1_uc010whs.1_Missense_Mutation_p.R979H|BRCA1_uc010cyz.2_Missense_Mutation_p.R932H|BRCA1_uc010cza.2_Missense_Mutation_p.R953H|BRCA1_uc010wht.1_Missense_Mutation_p.R683H	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	979					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGGTGGTATACGATATGGGTT	0.363			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			T	41244612	T	T	41244612	3	4	259	1	0	0	0	0	1	0	0	0	1498	536	19	1	2781	1	BRCA1	17	41244612	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	1928120	41244612	39950598	53	18593											
ITGA2B	3674	broad.mit.edu	37	chr17	42457990	42457990	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtacacagccacctggttggCcccgtaagctcccacgatca	9	16	1	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr17:42457990C>T	uc002igt.1	-	14	1449	c.1417G>A	c.(1417-1419)GCC>ACC	p.A473T	ITGA2B_uc002igu.1_5'UTR	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	473	Extracellular (Potential).|FG-GAP 7.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	ACCTGGTTGGCCCCGTAAGCT	0.592													T	42457990	T	T	42457990	3	4	259	1	0	0	0	0	1	0	0	0	7876	739	26	3	1770	3	ITGA2B	17	42457990	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	1213378	42457990	38737220	54	18594											
LRRC30	339291	broad.mit.edu	37	chr18	7231386	7231386	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atctgtctcacaaccagctcCgggttctccctcccgaggtg	9	16	3	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr18:7231386C>T	uc010wzk.1	+	1	250	c.250C>T	c.(250-252)CGG>TGG	p.R84W		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	84	LRR 1.									ovary(1)|liver(1)	2						CAACCAGCTCCGGGTTCTCCC	0.587													T	7231386	T	T	7231386	3	4	259	1	0	0	0	0	1	0	0	0	8985	643	23	2	252	2	LRRC30	18	7231386	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08		7231386	70845862	55	18595											
KHSRP	8570	broad.mit.edu	37	chr19	6420483	6420483	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actcttctgtcattgaagtcCtgtaaagagacacgccaaag	8	10	3	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr19:6420483C>T	uc002mer.3	-	5	536	c.426_splice	c.e5-1	p.R142_splice		NM_003685	NP_003676	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein						mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1						CATTGAAGTCCTGTAAAGAGA	0.567													T	6420483	T	T	6420483	5	4	259	1	0	0	0	0	0	0	1	0	8151	695	24	3	1774	3	KHSRP	19	6420483	Splice_Site	SNP	C	TCGA-76-4927-01A-01D-1486-08		6420483	52708500	56	18596											
ZNF136	7695	broad.mit.edu	37	chr19	12298584	12298584	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagttatctcaactcctttcGaacacatgaaatgattcaca	4	11	2	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr19:12298584G>A	uc002mti.2	+	4	1491	c.1391G>A	c.(1390-1392)CGA>CAA	p.R464Q	ZNF136_uc010xmh.1_Missense_Mutation_p.R398Q	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	464	C2H2-type 12.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						AACTCCTTTCGAACACATGAA	0.393													A	12298584	A	A	12298584	3	1	259	1	0	0	0	0	1	0	0	0	17723	1058	37	2	1405	2	ZNF136	19	12298584	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	5878101	12298584	46830399	57	18597											
RASAL3	64926	broad.mit.edu	37	chr19	15574925	15574925	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggccttggagagtcgaaggCgactggtccgtgactccttg	16	10	0	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr19:15574925C>T	uc002nbe.2	-	2	331	c.245G>A	c.(244-246)CGC>CAC	p.R82H		NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	82					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						GAGTCGAAGGCGACTGGTCCG	0.672													T	15574925	T	T	15574925	3	4	259	1	0	0	0	0	1	0	0	0	13065	768	27	1	2858	1	RASAL3	19	15574925	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08	3276341	15574925	43554058	58	18598											
USHBP1	83878	broad.mit.edu	37	chr19	17375061	17375061	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agggtgacacttacgggtggAgcatgcctccctcgccggct	14	13	0	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr19:17375061A>C	uc002nfs.1	-	2	161	c.48T>G	c.(46-48)GCT>GCG	p.A16A	USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Missense_Mutation_p.L2R|USHBP1_uc010eam.1_5'UTR	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	16							PDZ domain binding			ovary(1)	1						TTACGGGTGGAGCATGCCTCC	0.647													C	17375061	C	C	17375061	2	2	259	1	0	0	0	0	0	0	0	1	17034	291	11	5		5	USHBP1	19	17375061	Silent	SNP	A	TCGA-76-4927-01A-01D-1486-08	1800136	17375061	41753922	59	18599											
MAG	4099	broad.mit.edu	37	chr19	35786738	35786738	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagcttccagggccgcagccGcctcctgggggacctgggcc	16	16	0	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr19:35786738G>A	uc002nyy.1	+	4	418	c.269G>A	c.(268-270)CGC>CAC	p.R90H	MAG_uc002nyx.1_Missense_Mutation_p.R90H|MAG_uc010eds.1_Missense_Mutation_p.R65H|MAG_uc002nyz.1_Missense_Mutation_p.R90H	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	90	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GGCCGCAGCCGCCTCCTGGGG	0.652													A	35786738	A	A	35786738	3	1	259	1	0	0	0	0	1	0	0	0	9162	1087	38	1	275	1	MAG	19	35786738	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	18411677	35786738	23342245	60	18600											
PLD3	23646	broad.mit.edu	37	chr19	40872766	40872766	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtttctatgggaatacggCgacttgcatctctttgggcc	11	10	2	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr19:40872766C>T	uc002onm.3	+	5	587	c.189C>T	c.(187-189)GGC>GGT	p.G63G	PLD3_uc002onj.3_Silent_p.G63G|PLD3_uc002onk.3_Silent_p.G63G|PLD3_uc002onl.3_Silent_p.G63G|PLD3_uc002onn.2_Silent_p.G63G|PLD3_uc002ono.2_Nonsense_Mutation_p.R93*	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	63	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			GGGAATACGGCGACTTGCATC	0.627													T	40872766	T	T	40872766	2	4	259	1	0	0	0	0	0	0	0	1	12047	755	27	1		1	PLD3	19	40872766	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08	5086028	40872766	18256217	61	18601											
PSG1	5669	broad.mit.edu	37	chr19	43372476	43372476	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cctgaacggtaataggtgaaTgaagggtaaattctggggag	15	4	1	3			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr19:43372476T>A	uc002ovb.2	-	5	1158	c.1020A>T	c.(1018-1020)TCA>TCT	p.S340S	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Intron|PSG1_uc002our.1_Silent_p.S340S|PSG1_uc010eio.1_Silent_p.S340S|PSG1_uc002oux.1_Silent_p.S269S|PSG1_uc002ouy.1_Silent_p.S247S|PSG1_uc002ouz.1_Silent_p.S340S|PSG1_uc002ova.1_Silent_p.S247S|PSG1_uc002ovc.2_Silent_p.S247S|PSG1_uc002ovd.1_Silent_p.S340S	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	340	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				AATAGGTGAATGAAGGGTAAA	0.468													A	43372476	A	A	43372476	2	1	259	1	0	0	0	0	0	0	0	1	12653	1451	51	5		5	PSG1	19	43372476	Silent	SNP	T	TCGA-76-4927-01A-01D-1486-08	2499710	43372476	15756507	62	18602											
NLRP5	126206	broad.mit.edu	37	chr19	56538863	56538863	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagctcaagtcagaggtcGtgtctccccgttacctgtta	10	11	3	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr19:56538863G>A	uc002qmj.2	+	7	1264	c.1264G>A	c.(1264-1266)GTG>ATG	p.V422M	NLRP5_uc002qmi.2_Missense_Mutation_p.V403M	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	422	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GTCAGAGGTCGTGTCTCCCCG	0.547													A	56538863	A	A	56538863	3	1	259	1	0	0	0	0	1	0	0	0	10480	1145	40	1	1290	1	NLRP5	19	56538863	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	13166387	56538863	2590120	63	18603											
ZNF470	388566	broad.mit.edu	37	chr19	57088760	57088760	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aagcagtgtaataaagcattCagccagcttgcacaccttgc	8	11	1	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr19:57088760C>T	uc002qnl.3	+	6	1639	c.963C>T	c.(961-963)TTC>TTT	p.F321F	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	321	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ATAAAGCATTCAGCCAGCTTG	0.448													T	57088760	T	T	57088760	2	4	259	1	0	0	0	0	0	0	0	1	17926	825	29	3		3	ZNF470	19	57088760	Silent	SNP	C	TCGA-76-4927-01A-01D-1486-08	549897	57088760	2040223	64	18604											
GGTLC1	92086	broad.mit.edu	37	chr20	23966561	23966561	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccaccatccggacctggcCgtcctggcccaccatgatcg	9	19	0	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr20:23966561C>T	uc002wts.2	-	4	488	c.355G>A	c.(355-357)GGC>AGC	p.G119S	GGTLC1_uc002wtu.2_Missense_Mutation_p.G119S	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	119							gamma-glutamyltransferase activity			ovary(1)	1						CGGACCTGGCCGTCCTGGCCC	0.662													T	23966561	T	T	23966561	3	4	259	1	0	0	0	0	1	0	0	0	6365	652	23	2	334	2	GGTLC1	20	23966561	Missense_Mutation	SNP	C	TCGA-76-4927-01A-01D-1486-08		23966561	39058959	65	18605											
CDH22	64405	broad.mit.edu	37	chr20	44841697	44841697	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgaccttgaacacatcgccGccgctgctgctctcgtcctt	9	16	1	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chr20:44841697G>A	uc002xrm.2	-	5	1370	c.969C>T	c.(967-969)GGC>GGT	p.G323G	CDH22_uc010ghk.1_Silent_p.G323G|CDH22_uc002xrn.1_Silent_p.G74G	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	323	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				ACACATCGCCGCCGCTGCTGC	0.592													A	44841697	A	A	44841697	2	1	259	1	0	0	0	0	0	0	0	1	3107	1074	38	1		1	CDH22	20	44841697	Silent	SNP	G	TCGA-76-4927-01A-01D-1486-08	20875136	44841697	18183823	66	18606											
PHKA1	5255	broad.mit.edu	37	chrX	71895990	71895990	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcttgtctccacgttcccatAtcccgaagtcctggcataaa	6	14	2	0			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chrX:71895990A>G	uc004eax.3	-	6	849	c.548T>C	c.(547-549)ATA>ACA	p.I183T	PHKA1_uc004eay.3_Missense_Mutation_p.I183T|PHKA1_uc011mqi.1_Missense_Mutation_p.I183T	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	183					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					ACGTTCCCATATCCCGAAGTC	0.388													G	71895990	G	G	71895990	3	3	259	1	0	0	0	0	1	0	0	0	11843	449	16	4	3231	4	PHKA1	23	71895990	Missense_Mutation	SNP	A	TCGA-76-4927-01A-01D-1486-08		71895990	83374570	67	18607											
PHF6	84295	broad.mit.edu	37	chrX	133551307	133551307	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	aagacaaagctaaatacattGaaaatatgtcacgaggaatt	7	5	1	2			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chrX:133551307G>C	uc004exj.2	+	9	1145	c.943G>C	c.(943-945)GAA>CAA	p.E315Q	PHF6_uc004exk.2_Missense_Mutation_p.E315Q|PHF6_uc011mvk.1_Missense_Mutation_p.E281Q|PHF6_uc004exi.2_Missense_Mutation_p.E316Q	NM_001015877	NP_001015877	Q8IWS0	PHF6_HUMAN	PHD finger protein 6 isoform 1	315	PHD-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TAAATACATTGAAAATATGTC	0.353													C	133551307	C	C	133551307	3	2	259	1	0	0	0	0	1	0	0	0	11838	1291	45	5	1078	5	PHF6	23	133551307	Missense_Mutation	SNP	G	TCGA-76-4927-01A-01D-1486-08	61655317	133551307	21719253	68	18608											
SLITRK4	139065	broad.mit.edu	37	chrX	142717983	142717983	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agggctttgcctgcaacgatTccagagatcttggaaggatt	12	8	1	1			TCGA-76-4927-01A-01D-1486-08	TCGA-76-4927-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	2dc69425-dbfd-4228-ab78-541062b5c445	2da46cea-aae7-4e5e-ab52-93cc80132d37	g.chrX:142717983T>A	uc004fbx.2	-	2	1318	c.942A>T	c.(940-942)GGA>GGT	p.G314G	SLITRK4_uc004fby.2_Silent_p.G314G	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	314	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCAACGATTCCAGAGATCT	0.463													A	142717983	A	A	142717983	2	1	259	1	0	0	0	0	0	0	0	1	14745	1770	62	5		5	SLITRK4	23	142717983	Silent	SNP	T	TCGA-76-4927-01A-01D-1486-08	9166676	142717983	12552577	69	18609											
CHD5	26038	broad.mit.edu	37	chr1	6184051	6184051	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aggaggtgggcagggctggcGggcactggtgtgttggggtc	23	6	0	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:6184051G>C	uc001amb.1	-	31	4756	c.4656C>G	c.(4654-4656)CCC>CCG	p.P1552P	CHD5_uc001alz.1_Silent_p.P409P|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1552					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CAGGGCTGGCGGGCACTGGTG	0.677													C	6184051	C	C	6184051	2	2	260	1	0	0	0	0	0	0	0	1	3328	1103	39	5		5	CHD5	1	6184051	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08		6184051	243066570	1	18610											
PEX14	5195	broad.mit.edu	37	chr1	10555343	10555343	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctctgcagccaagctctactCcaggaagtgaaaatgtgctg	10	11	2	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:10555343C>G	uc001arn.2	+	2	70	c.49C>G	c.(49-51)CCA>GCA	p.P17A	PEX14_uc001arm.1_RNA|PEX14_uc009vmu.1_Missense_Mutation_p.P17A|PEX14_uc009vmv.2_5'UTR|PEX14_uc010oam.1_5'UTR|PEX14_uc010oan.1_Missense_Mutation_p.P17A|PEX14_uc001arl.2_RNA	NM_004565	NP_004556	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	17					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(1)	1	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		AAGCTCTACTCCAGGAAGTGA	0.428											OREG0013090	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	10555343	G	G	10555343	3	3	260	1	0	0	0	0	1	0	0	0	11742	855	30	5	55	5	PEX14	1	10555343	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	4371292	10555343	238695278	2	18611											
UBR4	23352	broad.mit.edu	37	chr1	19412732	19412732	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttggcattctgcagggcgGcactctcccactcttcccgg	11	15	3	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:19412732G>A	uc001bbi.2	-	101	14724	c.14720C>T	c.(14719-14721)GCC>GTC	p.A4907V	UBR4_uc010ocv.1_Missense_Mutation_p.A430V|UBR4_uc009vph.2_Missense_Mutation_p.A541V|UBR4_uc010ocw.1_Missense_Mutation_p.A571V|UBR4_uc001bbg.2_Missense_Mutation_p.A618V|UBR4_uc001bbh.2_Missense_Mutation_p.A616V	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4907					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CTGCAGGGCGGCACTCTCCCA	0.607													A	19412732	A	A	19412732	3	1	260	1	0	0	0	0	1	0	0	0	16901	1203	42	3	855	3	UBR4	1	19412732	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	8857389	19412732	229837889	3	18612											
FUCA1	2517	broad.mit.edu	37	chr1	24180899	24180899	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagacaatgccatgtcacgaCgatagccccaggaaaacttg	9	12	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:24180899C>T	uc001bie.2	-	5	965	c.920G>A	c.(919-921)CGT>CAT	p.R307H	FUCA1_uc009vqt.1_RNA	NM_000147	NP_000138	P04066	FUCO_HUMAN	fucosidase, alpha-L-1, tissue precursor	307					fucose metabolic process|glycosaminoglycan catabolic process	lysosome	alpha-L-fucosidase activity|cation binding			breast(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-24)|Colorectal(126;5.69e-08)|COAD - Colon adenocarcinoma(152;3.15e-06)|GBM - Glioblastoma multiforme(114;9.04e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|KIRC - Kidney renal clear cell carcinoma(1967;0.00342)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.144)		CATGTCACGACGATAGCCCCA	0.378													T	24180899	T	T	24180899	3	4	260	1	0	0	0	0	1	0	0	0	6094	536	19	1	496	1	FUCA1	1	24180899	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	4768167	24180899	225069722	4	18613											
PTPRF	5792	broad.mit.edu	37	chr1	44084401	44084401	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggccacatacactgtgcGcaccttcgcactccacaagg	9	16	0	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:44084401G>A	uc001cjr.2	+	26	4812	c.4472G>A	c.(4471-4473)CGC>CAC	p.R1491H	PTPRF_uc001cjs.2_Missense_Mutation_p.R1482H|PTPRF_uc001cju.2_Missense_Mutation_p.R880H|PTPRF_uc009vwt.2_Missense_Mutation_p.R1051H|PTPRF_uc001cjv.2_Missense_Mutation_p.R962H|PTPRF_uc001cjw.2_Missense_Mutation_p.R717H	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1491	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TACACTGTGCGCACCTTCGCA	0.572													A	44084401	A	A	44084401	3	1	260	1	0	0	0	0	1	0	0	0	12801	1087	38	1	4566	1	PTPRF	1	44084401	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	19903502	44084401	205166220	5	18614											
MUTYH	4595	broad.mit.edu	37	chr1	45797967	45797967	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccgggctgggtccaccagCtgctgggctagacccctaaa	14	14	0	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:45797967C>T	uc001cnm.2	-	10	1011	c.795G>A	c.(793-795)CAG>CAA	p.Q265Q	MUTYH_uc009vxn.2_Silent_p.Q90Q|MUTYH_uc001cnf.2_Silent_p.Q240Q|MUTYH_uc009vxo.2_Silent_p.Q240Q|MUTYH_uc001cng.2_Silent_p.Q251Q|MUTYH_uc001cnj.2_Silent_p.Q148Q|MUTYH_uc001cni.2_Silent_p.Q240Q|MUTYH_uc001cnh.2_Silent_p.Q241Q|MUTYH_uc001cno.2_Silent_p.Q148Q|MUTYH_uc001cnk.2_Silent_p.Q125Q|MUTYH_uc010oll.1_Intron|MUTYH_uc001cnl.2_Silent_p.Q254Q|MUTYH_uc009vxp.2_Silent_p.Q268Q|MUTYH_uc001cnn.2_Silent_p.Q255Q	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	265					depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					GGTCCACCAGCTGCTGGGCTA	0.597			Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				T	45797967	T	T	45797967	2	4	260	1	0	0	0	0	0	0	0	1	9993	796	28	3		3	MUTYH	1	45797967	Silent	SNP	C	TCGA-76-4928-01B-01D-1486-08	1713566	45797967	203452654	6	18615											
DENND2C	163259	broad.mit.edu	37	chr1	115167981	115167981	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	cctacgaggttttggcaaagGatttatggaaggtccacatt	11	7	0	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:115167981G>C	uc001efd.1	-	4	1327	c.625C>G	c.(625-627)CCT>GCT	p.P209A	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Missense_Mutation_p.P209A	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	209										skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTGGCAAAGGATTTATGGAA	0.378													C	115167981	C	C	115167981	3	2	260	1	0	0	0	0	1	0	0	0	4430	1174	41	5	2058	5	DENND2C	1	115167981	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	69370014	115167981	134082640	7	18616											
HIST2H3D	653604	broad.mit.edu	37	chr1	149785226	149785226	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acttgcgggcagtctgcttaGtacgggccatgctgtctcat	12	11	2	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:149785226G>C	uc010pbl.1	-	1	11	c.11C>G	c.(10-12)ACT>AGT	p.T4S	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	4					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						AGTCTGCTTAGTACGGGCCAT	0.567													C	149785226	C	C	149785226	3	2	260	1	0	0	0	0	1	0	0	0	7181	1029	36	5	401	5	HIST2H3D	1	149785226	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	34617245	149785226	99465395	8	18617											
FLG	2312	broad.mit.edu	37	chr1	152285914	152285914	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	cagtgctggtcccggtccgtCcatgggcagagtcaggctgt	15	12	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:152285914C>A	uc001ezu.1	-	3	1484	c.1448G>T	c.(1447-1449)GGA>GTA	p.G483V	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	483	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCGGTCCGTCCATGGGCAGA	0.607									Ichthyosis				A	152285914	A	A	152285914	3	1	260	1	0	0	0	0	1	0	0	0	5922	855	30	5	10741	5	FLG	1	152285914	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	2500688	152285914	96964707	9	18618											
UBAP2L	9898	broad.mit.edu	37	chr1	154242707	154242707	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcaacgtagccagaccagctCcatcccgcagaagccccaga	9	17	0	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:154242707C>T	uc001fep.3	+	27	3367	c.3200C>T	c.(3199-3201)TCC>TTC	p.S1067F	UBAP2L_uc010pel.1_Intron|UBAP2L_uc001feq.2_Intron|UBAP2L_uc001fer.2_Missense_Mutation_p.S280F|HAX1_uc001fet.2_5'Flank|HAX1_uc001fes.2_5'Flank|HAX1_uc010peo.1_5'Flank|HAX1_uc009wou.2_5'Flank|HAX1_uc009wov.2_5'Flank	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	1067					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAGACCAGCTCCATCCCGCAG	0.562													T	154242707	T	T	154242707	3	4	260	1	0	0	0	0	1	0	0	0	16835	855	30	3	3356	3	UBAP2L	1	154242707	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	1956793	154242707	95007914	10	18619											
SMG7	9887	broad.mit.edu	37	chr1	183486872	183486872	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caacactgcaaggccaggcaAagaatcgagcaaatccgaat	9	11	0	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr1:183486872A>G	uc001gqg.2	+	4	351	c.229A>G	c.(229-231)AAG>GAG	p.K77E	SMG7_uc010pob.1_Missense_Mutation_p.K106E|SMG7_uc001gqf.2_Missense_Mutation_p.K77E|SMG7_uc001gqh.2_Missense_Mutation_p.K77E|SMG7_uc001gqi.2_Missense_Mutation_p.K35E|SMG7_uc010poc.1_Missense_Mutation_p.K35E	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	77					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AGGCCAGGCAAAGAATCGAGC	0.443													G	183486872	G	G	183486872	3	3	260	1	0	0	0	0	1	0	0	0	14798	15	1	4	243	4	SMG7	1	183486872	Missense_Mutation	SNP	A	TCGA-76-4928-01B-01D-1486-08	29244165	183486872	65763749	11	18620											
APOB	338	broad.mit.edu	37	chr2	21230333	21230333	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgattattgtgtaaggtagaCgcatttcaggaattgttaaa	10	3	1	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr2:21230333C>T	uc002red.2	-	26	9535	c.9407G>A	c.(9406-9408)CGT>CAT	p.R3136H		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3136					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTAAGGTAGACGCATTTCAGG	0.373													T	21230333	T	T	21230333	3	4	260	1	0	0	0	0	1	0	0	0	785	536	19	1	4300	1	APOB	2	21230333	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08		21230333	221969040	12	18621											
NRXN1	9378	broad.mit.edu	37	chr2	50573861	50573861	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcaaggatgccggtgacctgTagattgcaataggcactgaa	13	8	0	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr2:50573861T>C	uc010fbp.2	-	1	1034	c.227A>G	c.(226-228)TAC>TGC	p.Y76C	NRXN1_uc002rxb.3_Intron|NRXN1_uc010fbq.2_Intron|NRXN1_uc002rxe.3_Intron|NRXN1_uc002rxc.1_Intron	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	76	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CGGTGACCTGTAGATTGCAAT	0.602													C	50573861	C	C	50573861	3	2	260	1	0	0	0	0	1	0	0	0	10665	1638	57	4	1219	4	NRXN1	2	50573861	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08	29343528	50573861	192625512	13	18622											
ETAA1	54465	broad.mit.edu	37	chr2	67631223	67631226	+	Frame_Shift_Del	DEL	CAAA	-	-													ttcaccaaattcaaataaatCaaacaaattatccactggaa							TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr2:67631223_67631226delCAAA	uc002sdz.1	+	5	1548_1551	c.1409_1412delCAAA	c.(1408-1413)TCAAACfs	p.S470fs		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	470_471						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						TCAAATAAATCAAACAAATTATCC	0.265													-	67631226	-	-	67631223	7	5	260	1	0	1	0	1	0	0	0	0	5267	838	29	0	1427	0	ETAA1	2	67631223	Frame_Shift_Del	DEL	CAAA	TCGA-76-4928-01B-01D-1486-08	17057362	67631223	175568150	14	18623											
SLC9A4	389015	broad.mit.edu	37	chr2	103141552	103141552	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctaaagagattctgatcCgccgccagaacaccttaagg	10	11	1	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr2:103141552C>T	uc002tbz.3	+	10	2345	c.1888C>T	c.(1888-1890)CGC>TGC	p.R630C		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	630	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GATTCTGATCCGCCGCCAGAA	0.502													T	103141552	T	T	103141552	3	4	260	1	0	0	0	0	1	0	0	0	14716	652	23	2	1926	2	SLC9A4	2	103141552	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	35510329	103141552	140057821	15	18624											
LY75	4065	broad.mit.edu	37	chr2	160711043	160711043	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaggtccatgaattccagcaCggtctaaagaagaagaagaa	11	7	1	5			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr2:160711043C>T	uc002ubc.3	-	18	2492	c.2423G>A	c.(2422-2424)CGT>CAT	p.R808H	LY75_uc002ubb.3_Missense_Mutation_p.R808H|LY75_uc010fos.2_Missense_Mutation_p.R808H	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	808	Extracellular (Potential).				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		AATTCCAGCACGGTCTAAAGA	0.363													T	160711043	T	T	160711043	3	4	260	1	0	0	0	0	1	0	0	0	9099	536	19	1	2817	1	LY75	2	160711043	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	57569491	160711043	82488330	16	18625											
TRANK1	9881	broad.mit.edu	37	chr3	36898731	36898731	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccaggtcatgttatcgaagtCctggaggcaggcctcaatct	11	11	3	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr3:36898731C>T	uc003cgj.2	-	3	1002	c.700G>A	c.(700-702)GAC>AAC	p.D234N		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	784					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TTATCGAAGTCCTGGAGGCAG	0.502													T	36898731	T	T	36898731	3	4	260	1	0	0	0	0	1	0	0	0	16451	855	30	3	6475	3	TRANK1	3	36898731	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08		36898731	161123699	17	18626											
CEP97	79598	broad.mit.edu	37	chr3	101451368	101451368	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccttaactgaattggaacagTtgtcgattatgaacaatcct	7	8	0	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr3:101451368T>G	uc003dvk.1	+	6	625	c.598T>G	c.(598-600)TTG>GTG	p.L200V	CEP97_uc010hpm.1_Missense_Mutation_p.L166V|CEP97_uc011bhf.1_Missense_Mutation_p.L200V|CEP97_uc003dvl.1_5'UTR|CEP97_uc003dvm.1_Missense_Mutation_p.L38V	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	200	LRR 8.					centrosome|nucleus	protein binding			ovary(2)	2						ATTGGAACAGTTGTCGATTAT	0.418													G	101451368	G	G	101451368	3	3	260	1	0	0	0	0	1	0	0	0	3263	1722	60	5	620	5	CEP97	3	101451368	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08	64552637	101451368	96571062	18	18627											
TMPRSS7	344805	broad.mit.edu	37	chr3	111799811	111799811	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agaaaaagtgatggaaaatgGattttgactggcattgttag	12	2	0	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr3:111799811G>T	uc010hqb.2	+	16	2204	c.2034G>T	c.(2032-2034)TGG>TGT	p.W678C	TMPRSS7_uc011bhr.1_Missense_Mutation_p.W533C	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	804	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						ATGGAAAATGGATTTTGACTG	0.403													T	111799811	T	T	111799811	3	4	260	1	0	0	0	0	1	0	0	0	16249	1183	41	5	2092	5	TMPRSS7	3	111799811	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	10348443	111799811	86222619	19	18628											
MECOM	2122	broad.mit.edu	37	chr3	168849257	168849257	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtttcatggggatagtcttcGctcttcatgaacagcagaag	11	8	4	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr3:168849257G>A	uc003ffi.3	-	3	278	c.9C>T	c.(7-9)AGC>AGT	p.S3S	MECOM_uc010hwk.1_Silent_p.S26S|MECOM_uc003ffj.3_Silent_p.S67S|MECOM_uc011bpi.1_Silent_p.S3S|MECOM_uc003ffn.3_Silent_p.S3S|MECOM_uc003ffk.2_Silent_p.S3S|MECOM_uc003ffl.2_Silent_p.S163S|MECOM_uc011bpj.1_Silent_p.S191S|MECOM_uc011bpk.1_5'UTR|MECOM_uc010hwn.2_Silent_p.S191S|MECOM_uc003ffm.1_Silent_p.S67S	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	3	Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GATAGTCTTCGCTCTTCATGA	0.458													A	168849257	A	A	168849257	2	1	260	1	0	0	0	0	0	0	0	1	9422	1078	38	1		1	MECOM	3	168849257	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08	57049446	168849257	29173173	20	18629											
PIK3CA	5290	broad.mit.edu	37	chr3	178916854	178916854	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctcaagaagcagaaagggaaGaattttttgatgaaacaaga	10	4	1	6			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr3:178916854G>A	uc003fjk.2	+	2	398	c.241G>A	c.(241-243)GAA>AAA	p.E81K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	81	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E81K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGAAAGGGAAGAATTTTTTGA	0.358		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178916854	A	A	178916854	3	1	260	1	0	0	0	0	1	0	0	0	11913	943	33	3	243	3	PIK3CA	3	178916854	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	10067597	178916854	19105576	21	18630											
LAMP3	27074	broad.mit.edu	37	chr3	182870190	182870190	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgtgagattcacaaatccGccctgaaaattcaacagaag	7	9	2	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr3:182870190G>A	uc003flh.3	-	3	1085	c.861C>T	c.(859-861)GGC>GGT	p.G287G		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	287	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			TCACAAATCCGCCCTGAAAAT	0.512													A	182870190	A	A	182870190	2	1	260	1	0	0	0	0	0	0	0	1	8619	1074	38	1		1	LAMP3	3	182870190	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08	3953336	182870190	15152240	22	18631											
LSG1	55341	broad.mit.edu	37	chr3	194373563	194373563	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agatggctaaaattgtgtatCtgcctcttctgtggggtttt	11	6	3	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr3:194373563C>T	uc003fui.2	-	8	1383	c.1068G>A	c.(1066-1068)CAG>CAA	p.Q356Q		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	356					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		AATTGTGTATCTGCCTCTTCT	0.507													T	194373563	T	T	194373563	2	4	260	1	0	0	0	0	0	0	0	1	9049	912	32	3		3	LSG1	3	194373563	Silent	SNP	C	TCGA-76-4928-01B-01D-1486-08	11503373	194373563	3648867	23	18632											
PCDH7	5099	broad.mit.edu	37	chr4	30725808	30725808	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcaaaaaagatcacgaagacTtttttacaccccaacagcat	5	11	1	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr4:30725808T>C	uc003gsk.1	+	1	3772	c.2764T>C	c.(2764-2766)TTT>CTT	p.F922L	PCDH7_uc011bxw.1_Missense_Mutation_p.F875L|PCDH7_uc011bxx.1_Missense_Mutation_p.F922L	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	922	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						TCACGAAGACTTTTTTACACC	0.383													C	30725808	C	C	30725808	3	2	260	1	0	0	0	0	1	0	0	0	11516	1609	56	4	2766	4	PCDH7	4	30725808	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08		30725808	160428468	24	18633											
SMR3B	10879	broad.mit.edu	37	chr4	71255518	71255518	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatcccacctcctcctcccGcaccctatggtccagggata	7	18	0	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr4:71255518G>A	uc011cas.1	+	3	274	c.193G>A	c.(193-195)GCA>ACA	p.A65T	SMR3B_uc003hfh.2_Missense_Mutation_p.A65T	NM_006685	NP_006676	P02814	SMR3B_HUMAN	submaxillary gland androgen regulated protein 3	65	Poly-Pro.|Pro-rich.					extracellular space				skin(1)	1		all_hematologic(202;0.196)				TCCTCCTCCCGCACCCTATGG	0.602													A	71255518	A	A	71255518	3	1	260	1	0	0	0	0	1	0	0	0	14812	1087	38	1	199	1	SMR3B	4	71255518	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	40529710	71255518	119898758	25	18634											
AFM	173	broad.mit.edu	37	chr4	74364954	74364954	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agtgaagagtttgcctgtgtTgataatttggtgagcatggc	14	4	0	4			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr4:74364954T>A	uc003hhb.2	+	11	1444	c.1413T>A	c.(1411-1413)GTT>GTA	p.V471V		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	471	Albumin 3.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTGCCTGTGTTGATAATTTGG	0.383													A	74364954	A	A	74364954	2	1	260	1	0	0	0	0	0	0	0	1	361	1799	63	5		5	AFM	4	74364954	Silent	SNP	T	TCGA-76-4928-01B-01D-1486-08	3109436	74364954	116789322	26	18635											
KLHL8	57563	broad.mit.edu	37	chr4	88091238	88091238	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccatttactcaccaactacGtataagcaaccatgaagctt	4	13	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr4:88091238G>A	uc011cdb.1	-	8	1915	c.1530C>T	c.(1528-1530)TAC>TAT	p.Y510Y	KLHL8_uc003hql.1_Silent_p.Y510Y|KLHL8_uc003hqm.1_Silent_p.Y434Y|KLHL8_uc003hqn.1_Silent_p.Y327Y|KLHL8_uc010ikj.1_Silent_p.Y159Y	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	510	Kelch 5.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		CACCAACTACGTATAAGCAAC	0.358													A	88091238	A	A	88091238	2	1	260	1	0	0	0	0	0	0	0	1	8395	1140	40	1		1	KLHL8	4	88091238	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08	13726284	88091238	103063038	27	18636											
ADH1A	124	broad.mit.edu	37	chr4	100208729	100208729	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatgtatttcaccttaatacGaacttcatgggccttaggag	8	8	2	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr4:100208729G>A	uc003hur.1	-	2	183	c.112C>T	c.(112-114)CGT>TGT	p.R38C	uc003hum.1_Intron|ADH1A_uc011ceg.1_Missense_Mutation_p.R38C|ADH1A_uc010ilf.1_5'Flank|ADH1A_uc010ilg.1_Missense_Mutation_p.R38C	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	38					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	ACCTTAATACGAACTTCATGG	0.348													A	100208729	A	A	100208729	3	1	260	1	0	0	0	0	1	0	0	0	307	1058	37	2	1047	2	ADH1A	4	100208729	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	12117491	100208729	90945547	28	18637											
DCHS2	54798	broad.mit.edu	37	chr4	155241881	155241881	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggatgagaaatggattcGtgccagggttgtgggattca	17	4	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr4:155241881G>A	uc003inw.2	-	14	3305	c.3305C>T	c.(3304-3306)ACG>ATG	p.T1102M		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1102	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AAATGGATTCGTGCCAGGGTT	0.453													A	155241881	A	A	155241881	3	1	260	1	0	0	0	0	1	0	0	0	4288	1145	40	1	5493	1	DCHS2	4	155241881	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	55033152	155241881	35912395	29	18638											
TLL1	7092	broad.mit.edu	37	chr4	166964454	166964454	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggaggtgagatacgtaaaaaTgaaggacagattcagtctcc	12	6	2	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr4:166964454T>C	uc003irh.1	+	12	2054	c.1407T>C	c.(1405-1407)AAT>AAC	p.N469N	TLL1_uc011cjn.1_Silent_p.N469N|TLL1_uc011cjo.1_Silent_p.N293N	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	469	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TACGTAAAAATGAAGGACAGA	0.408													C	166964454	C	C	166964454	2	2	260	1	0	0	0	0	0	0	0	1	15942	1461	51	4		4	TLL1	4	166964454	Silent	SNP	T	TCGA-76-4928-01B-01D-1486-08	11722573	166964454	24189822	30	18639											
GALNT7	51809	broad.mit.edu	37	chr4	174235303	174235303	+	Frame_Shift_Del	DEL	A	-	-													acctcacactaccctttgccAcccaaaaatgttgactgggg							TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr4:174235303delA	uc003isz.3	+	9	1667	c.1584delA	c.(1582-1584)CCAfs	p.P528fs	GALNT7_uc011ckb.1_Frame_Shift_Del_p.P305fs	NM_017423	NP_059119	Q86SF2	GALT7_HUMAN	polypeptide N-acetylgalactosaminyltransferase 7	528	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		ACCCTTTGCCACCCAAAAATG	0.393													-	174235303	-	-	174235303	7	5	260	1	0	1	0	1	0	0	0	0	6218	146	6	0	1618	0	GALNT7	4	174235303	Frame_Shift_Del	DEL	A	TCGA-76-4928-01B-01D-1486-08	7270849	174235303	16918973	31	18640											
ANKRD55	79722	broad.mit.edu	37	chr5	55407551	55407551	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggttgagcacgttgaaccGtctctccttcttctggggcc	11	12	3	2	rs147414262	byFrequency	TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr5:55407551G>A	uc003jqu.2	-	10	1176	c.1024C>T	c.(1024-1026)CGG>TGG	p.R342W	ANKRD55_uc003jqt.2_Missense_Mutation_p.R54W	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	341										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				ACGTTGAACCGTCTCTCCTTC	0.512													A	55407551	A	A	55407551	3	1	260	1	0	0	0	0	1	0	0	0	681	1144	40	1	832	1	ANKRD55	5	55407551	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08		55407551	125507709	32	18641											
FBN2	2201	broad.mit.edu	37	chr5	127729056	127729056	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atccatgcaaagtctgcgatAttcctctagaagaaaagaaa	7	8	2	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr5:127729056A>G	uc003kuu.2	-	10	1676	c.1237T>C	c.(1237-1239)TAT>CAT	p.Y413H	FBN2_uc003kuv.2_Missense_Mutation_p.Y380H	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	413	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AGTCTGCGATATTCCTCTAGA	0.473													G	127729056	G	G	127729056	3	3	260	1	0	0	0	0	1	0	0	0	5703	449	16	4	7725	4	FBN2	5	127729056	Missense_Mutation	SNP	A	TCGA-76-4928-01B-01D-1486-08	72321505	127729056	53186204	33	18642											
SPOCK1	6695	broad.mit.edu	37	chr5	136314406	136314406	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcatcatcctctgtcacGgctcgggtgtgcaccctcag	9	16	5	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr5:136314406G>A	uc003lbo.2	-	10	1448	c.1257C>T	c.(1255-1257)GCC>GCT	p.A419A	SPOCK1_uc003lbp.2_Silent_p.A419A	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	419					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCTCTGTCACGGCTCGGGTGT	0.522													A	136314406	A	A	136314406	2	1	260	1	0	0	0	0	0	0	0	1	15078	1103	39	2		2	SPOCK1	5	136314406	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08	8585350	136314406	44600854	34	18643											
PCDHA2	56146	broad.mit.edu	37	chr5	140174848	140174848	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggagctgtgcgggcggagcgCggaatgtagcatccacgtgg	19	9	0	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr5:140174848C>T	uc003lhd.2	+	1	405	c.299C>T	c.(298-300)GCG>GTG	p.A100V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.A100V|PCDHA2_uc011czy.1_Missense_Mutation_p.A100V	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	100	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGGAGCGCGGAATGTAGC	0.542													T	140174848	T	T	140174848	3	4	260	1	0	0	0	0	1	0	0	0	11524	768	27	1	301	1	PCDHA2	5	140174848	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	3860442	140174848	40740412	35	18644											
PCDHB6	56130	broad.mit.edu	37	chr5	140531524	140531524	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgcccttcgtgttgtacccGctgcagaacggctccgcgcc	11	17	0	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr5:140531524G>A	uc003lir.2	+	1	1686	c.1686G>A	c.(1684-1686)CCG>CCA	p.P562P	PCDHB6_uc011dah.1_Silent_p.P426P	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	562	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTGTACCCGCTGCAGAACG	0.726													A	140531524	A	A	140531524	2	1	260	1	0	0	0	0	0	0	0	1	11546	1074	38	1		1	PCDHB6	5	140531524	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08	356676	140531524	40383736	36	18645											
UNC5A	90249	broad.mit.edu	37	chr5	176301280	176301280	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcagacaacccccatctgcTcaccatccagccggacctca	6	19	3	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr5:176301280T>C	uc003mey.2	+	8	1283	c.1091T>C	c.(1090-1092)CTC>CCC	p.L364P	UNC5A_uc010jkg.1_Missense_Mutation_p.L324P	NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	364	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCATCTGCTCACCATCCAG	0.642													C	176301280	C	C	176301280	3	2	260	1	0	0	0	0	1	0	0	0	16988	1551	54	4	1121	4	UNC5A	5	176301280	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08	35769756	176301280	4613980	37	18646											
SKIV2L	6499	broad.mit.edu	37	chr6	31936254	31936254	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagggtgggctccgggcccGgaagctggaggagctgatcc	19	10	0	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr6:31936254G>A	uc003nyn.1	+	24	3397	c.3008G>A	c.(3007-3009)CGG>CAG	p.R1003Q	SKIV2L_uc011dou.1_Missense_Mutation_p.R845Q|SKIV2L_uc011dov.1_Missense_Mutation_p.R810Q|STK19_uc003nyt.2_5'Flank	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	1003						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CTCCGGGCCCGGAAGCTGGAG	0.632													A	31936254	A	A	31936254	3	1	260	1	0	0	0	0	1	0	0	0	14359	1116	39	2	3102	2	SKIV2L	6	31936254	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08		31936254	139178813	38	18647											
DNAH8	1769	broad.mit.edu	37	chr6	38903432	38903432	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taataagcggaagatgaaagAacttgaagataacctcctct	8	7	1	5			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr6:38903432A>G	uc003ooe.1	+	75	11471	c.10871A>G	c.(10870-10872)GAA>GGA	p.E3624G	DNAH8_uc003oog.1_Missense_Mutation_p.E73G|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAGATGAAAGAACTTGAAGAT	0.308													G	38903432	G	G	38903432	3	3	260	1	0	0	0	0	1	0	0	0	4607	246	9	4	11161	4	DNAH8	6	38903432	Missense_Mutation	SNP	A	TCGA-76-4928-01B-01D-1486-08	6967178	38903432	132211635	39	18648											
PKHD1	5314	broad.mit.edu	37	chr6	51497434	51497434	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gccatgaggccacagaggacAgggaagcagccaggatgatg	16	9	0	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr6:51497434A>T	uc003pah.1	-	65	11870	c.11594T>A	c.(11593-11595)CTG>CAG	p.L3865Q		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3865	Helical; (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CACAGAGGACAGGGAAGCAGC	0.478													T	51497434	T	T	51497434	3	4	260	1	0	0	0	0	1	0	0	0	11971	188	7	5	642	5	PKHD1	6	51497434	Missense_Mutation	SNP	A	TCGA-76-4928-01B-01D-1486-08	12594002	51497434	119617633	40	18649											
DLL1	28514	broad.mit.edu	37	chr6	170592139	170592140	+	Frame_Shift_Ins	INS	-	TC	TC													acaccgactggtacttggtgINStcttttgaagttgaacagcc							TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr6:170592139_170592140insTC	uc003qxm.2	-	10	2572_2573	c.2102_2103insGA	c.(2101-2103)GACfs	p.D701fs		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	701	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		GGTACTTGGTGTCTTTTGAAGT	0.485													TC	170592140	TC	TC	170592139	7	5	260	1	0	1	1	0	0	0	0	0	4566	1368	48	0	76	0	DLL1	6	170592139	Frame_Shift_Ins	INS	-	TCGA-76-4928-01B-01D-1486-08	119094705	170592139	522928	41	18650											
ZNF679	168417	broad.mit.edu	37	chr7	63709526	63709526	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaccgggatcccctggaagcCgagaaatggtgagtgctggg	17	9	0	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr7:63709526C>A	uc003tsx.2	+	2	300	c.31C>A	c.(31-33)CGA>AGA	p.R11R		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCCTGGAAGCCGAGAAATGGT	0.572													A	63709526	A	A	63709526	2	1	260	1	0	0	0	0	0	0	0	1	18083	644	23	5		5	ZNF679	7	63709526	Silent	SNP	C	TCGA-76-4928-01B-01D-1486-08		63709526	95429137	42	18651											
GATS	352954	broad.mit.edu	37	chr7	99821643	99821643	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgccaccgccggacaccacGttcagggccagccaggtggc	13	17	1	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr7:99821643G>A	uc003uua.3	-	3	522	c.273C>T	c.(271-273)AAC>AAT	p.N91N	GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc010lgt.2_RNA|GATS_uc011kjl.1_5'Flank|GATS_uc010lgu.2_RNA	NM_178831	NP_849153	Q8NAP1	GATS_HUMAN	GATS, stromal antigen 3 opposite strand	91											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGGACACCACGTTCAGGGCCA	0.622													A	99821643	A	A	99821643	2	1	260	1	0	0	0	0	0	0	0	1	6264	1136	40	1		1	GATS	7	99821643	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08	36112117	99821643	59317020	43	18652											
C7orf53	286006	broad.mit.edu	37	chr7	112129963	112129963	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaataacatgatcgtaaagCgactcaaccaactcaaccaa	4	12	3	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr7:112129963C>T	uc011kmq.1	+	4	490	c.355C>T	c.(355-357)CGA>TGA	p.R119*	C7orf53_uc003vgl.2_RNA|C7orf53_uc003vgm.2_Nonsense_Mutation_p.R119*	NM_001134468	NP_001127940	Q8N8F7	CG053_HUMAN	hypothetical protein LOC286006	119	Potential.					integral to membrane				ovary(1)	1						GATCGTAAAGCGACTCAACCA	0.388													T	112129963	T	T	112129963	4	4	260	1	0	0	0	0	0	1	0	0	2402	760	27	1	365	1	C7orf53	7	112129963	Nonsense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	12308320	112129963	47008700	44	18653											
PLXNA4	91584	broad.mit.edu	37	chr7	131817922	131817922	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgcgttcatgtcttggtcGctgatggctggcatcttccc	11	11	3	1	rs114567124	by1000genomes	TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr7:131817922G>A	uc003vra.3	-	31	5704	c.5475C>T	c.(5473-5475)AGC>AGT	p.S1825S	PLXNA4_uc003vqz.3_Silent_p.S110S	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1825	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGTCTTGGTCGCTGATGGCTG	0.507													A	131817922	A	A	131817922	2	1	260	1	0	0	0	0	0	0	0	1	12122	1078	38	1		1	PLXNA4	7	131817922	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08	19687959	131817922	27320741	45	18654											
SVOPL	136306	broad.mit.edu	37	chr7	138305867	138305867	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatccccaaagcgcgcatcGtggtggggtagacctgcagg	14	13	0	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr7:138305867G>A	uc011kqh.1	-	13	1277	c.1277C>T	c.(1276-1278)ACG>ATG	p.T426M	SVOPL_uc003vue.2_Missense_Mutation_p.T274M	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	426						integral to membrane	transmembrane transporter activity				0						AGCGCGCATCGTGGTGGGGTA	0.597													A	138305867	A	A	138305867	3	1	260	1	0	0	0	0	1	0	0	0	15421	1145	40	1	213	1	SVOPL	7	138305867	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	6487945	138305867	20832796	46	18655											
BRAF	673	broad.mit.edu	37	chr7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acccactccatcgagatttcActgtagctagaccaaaatca	5	13	2	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				T	140453136	T	T	140453136	3	4	260	1	0	0	0	0	1	0	0	0	1496	159	6	5	517	5	BRAF	7	140453136	Missense_Mutation	SNP	A	TCGA-76-4928-01B-01D-1486-08	2147269	140453136	18685527	47	18656											
C7orf33	202865	broad.mit.edu	37	chr7	148288176	148288176	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgggtccacgttaggggCggtccaggtcaatttaactt	13	8	1	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr7:148288176C>T	uc003wew.2	+	1	520	c.159C>T	c.(157-159)GGC>GGT	p.G53G		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	53										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			ACGTTAGGGGCGGTCCAGGTC	0.512													T	148288176	T	T	148288176	2	4	260	1	0	0	0	0	0	0	0	1	2388	755	27	1		1	C7orf33	7	148288176	Silent	SNP	C	TCGA-76-4928-01B-01D-1486-08	7835040	148288176	10850487	48	18657											
NPBWR1	2831	broad.mit.edu	37	chr8	53853296	53853296	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcaccgtggtggcgctcaccAccgacctcccgcagacgccg	12	19	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr8:53853296A>G	uc011ldu.1	+	1	829	c.829A>G	c.(829-831)ACC>GCC	p.T277A		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	277	Extracellular (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				GGCGCTCACCACCGACCTCCC	0.642													G	53853296	G	G	53853296	3	3	260	1	0	0	0	0	1	0	0	0	10568	159	6	4	831	4	NPBWR1	8	53853296	Missense_Mutation	SNP	A	TCGA-76-4928-01B-01D-1486-08		53853296	92510726	49	18658											
KCNS2	3788	broad.mit.edu	37	chr8	99441064	99441064	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtggtggagagcacacctaCtttagccaacttgggcaggg	15	9	0	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr8:99441064C>A	uc003yin.2	+	2	1207	c.857C>A	c.(856-858)ACT>AAT	p.T286N		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	286	Extracellular (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			AGCACACCTACTTTAGCCAAC	0.557													A	99441064	A	A	99441064	3	1	260	1	0	0	0	0	1	0	0	0	8089	565	20	5	859	5	KCNS2	8	99441064	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	45587768	99441064	46922958	50	18659											
FBP1	2203	broad.mit.edu	37	chr9	97367792	97367792	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagaaatatccctccgtagaCcagagtgcgatgaacatcag	9	11	1	4			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr9:97367792C>A	uc004auw.3	-	6	1103	c.772G>T	c.(772-774)GTC>TTC	p.V258F	FBP1_uc010mrl.2_Missense_Mutation_p.V258F	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	258					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	CCTCCGTAGACCAGAGTGCGA	0.408													A	97367792	A	A	97367792	3	1	260	1	0	0	0	0	1	0	0	0	5705	507	18	5	252	5	FBP1	9	97367792	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08		97367792	43845639	51	18660											
LHX2	9355	broad.mit.edu	37	chr9	126794913	126794913	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aactgtgacgtccgtcttaaCttctgtgcctggcaacctgg	10	12	2	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr9:126794913C>T	uc004boe.1	+	5	1887	c.1148C>T	c.(1147-1149)ACT>ATT	p.T383I	LHX2_uc010mwi.1_Missense_Mutation_p.T391I	NM_004789	NP_004780	P50458	LHX2_HUMAN	LIM homeobox protein 2	383						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCCGTCTTAACTTCTGTGCCT	0.592													T	126794913	T	T	126794913	3	4	260	1	0	0	0	0	1	0	0	0	8771	565	20	3	1166	3	LHX2	9	126794913	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	29427121	126794913	14418518	52	18661											
PNPLA7	375775	broad.mit.edu	37	chr9	140374853	140374853	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgggtccagggtgtgagcgTgccatctacctggtagagca	15	10	1	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr9:140374853T>C	uc004cnf.2	-	22	2753	c.2416A>G	c.(2416-2418)ACG>GCG	p.T806A	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_Missense_Mutation_p.T72A|PNPLA7_uc004cne.1_Missense_Mutation_p.T72A|PNPLA7_uc011mfa.1_Missense_Mutation_p.T214A|PNPLA7_uc010ncj.1_Missense_Mutation_p.T831A	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	806					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GGTGTGAGCGTGCCATCTACC	0.662													C	140374853	C	C	140374853	3	2	260	1	0	0	0	0	1	0	0	0	12170	1696	59	4	1589	4	PNPLA7	9	140374853	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08	13579940	140374853	838578	53	18662											
FAM196A	642938	broad.mit.edu	37	chr10	128974485	128974485	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggacagctgtgtgtccctctGctcattctgtgcctcgcaga	11	13	3	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr10:128974485G>A	uc001lju.1	-	1	216	c.175C>T	c.(175-177)CAG>TAG	p.Q59*	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Nonsense_Mutation_p.Q59*|FAM196A_uc001ljv.1_Nonsense_Mutation_p.Q59*|FAM196A_uc009yap.1_Nonsense_Mutation_p.Q59*	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	59										ovary(2)	2						GTGTCCCTCTGCTCATTCTGT	0.587													A	128974485	A	A	128974485	4	1	260	1	0	0	0	0	0	1	0	0	5528	1328	46	3	1276	3	FAM196A	10	128974485	Nonsense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08		128974485	6560262	54	18663											
LUZP2	338645	broad.mit.edu	37	chr11	25100153	25100153	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtgaaaaaagccccagaaaaAccattgaccagctttgaagg	9	9	0	4			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr11:25100153A>G	uc001mqs.2	+	12	1224	c.990A>G	c.(988-990)AAA>AAG	p.K330K	LUZP2_uc009yif.2_Silent_p.K244K|LUZP2_uc009yig.2_Silent_p.K288K	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	330						extracellular region				ovary(1)|skin(1)	2						CCCCAGAAAAACCATTGACCA	0.348													G	25100153	G	G	25100153	2	3	260	1	0	0	0	0	0	0	0	1	9087	40	2	4		4	LUZP2	11	25100153	Silent	SNP	A	TCGA-76-4928-01B-01D-1486-08		25100153	109906363	55	18664											
SPRYD5	84767	broad.mit.edu	37	chr11	55655555	55655555	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atcagagctgaatatcagaaGatgcctgcatttctccatga	8	9	3	5			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr11:55655555G>T	uc010rip.1	+	4	647	c.555G>T	c.(553-555)AAG>AAT	p.K185N	SPRYD5_uc010riq.1_Missense_Mutation_p.K42N	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	185						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				AATATCAGAAGATGCCTGCAT	0.398													T	55655555	T	T	55655555	3	4	260	1	0	0	0	0	1	0	0	0	15110	933	33	5	565	5	SPRYD5	11	55655555	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	30555402	55655555	79350961	56	18665											
ARHGAP20	57569	broad.mit.edu	37	chr11	110495025	110495025	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttattttttatcttaaagtTattgttatatctagaaagat	4	2	2	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr11:110495025T>C	uc001pkz.1	-	5	649	c.364A>G	c.(364-366)AAC>GAC	p.N122D	ARHGAP20_uc001pky.1_Missense_Mutation_p.N99D|ARHGAP20_uc009yyb.1_Missense_Mutation_p.N86D|ARHGAP20_uc001pla.1_Missense_Mutation_p.N86D	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	122	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		atCTTAAAGTTATTGTTATAT	0.269													C	110495025	C	C	110495025	3	2	260	1	0	0	0	0	1	0	0	0	870	1754	61	4	3259	4	ARHGAP20	11	110495025	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08	54839470	110495025	24511491	57	18666											
TMPRSS13	84000	broad.mit.edu	37	chr11	117789400	117789400	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtgtaccagctggagatgCctgggctggagatgcccggc	17	10	0	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr11:117789400C>T	uc001prs.1	-	2	268	c.175G>A	c.(175-177)GCA>ACA	p.A59T	TMPRSS13_uc009yzr.1_5'UTR|TMPRSS13_uc001prt.1_5'UTR|TMPRSS13_uc001pru.1_Missense_Mutation_p.A59T	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	59	4 X 5 AA repeats of T-P-P-G-R.|1-8.|12 X 5 AA repeats of A-S-P-A-[GLQR].|Cytoplasmic (Potential).|Ala-rich.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GCTGGAGATGCCTGGGCTGGA	0.697													T	117789400	T	T	117789400	3	4	260	1	0	0	0	0	1	0	0	0	16242	739	26	3	1576	3	TMPRSS13	11	117789400	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	7294375	117789400	17217116	58	18667											
TREH	11181	broad.mit.edu	37	chr11	118530175	118530175	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgggatcccatactggtaagTcaggatccggttgtcctaga	12	10	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr11:118530175T>C	uc001pty.1	-	12	1381	c.1336A>G	c.(1336-1338)ACT>GCT	p.T446A	TREH_uc009zaj.1_Missense_Mutation_p.T415A|TREH_uc001ptz.1_Missense_Mutation_p.T323A	NM_007180	NP_009111	O43280	TREA_HUMAN	trehalase precursor	446					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			pancreas(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		TACTGGTAAGTCAGGATCCGG	0.617											OREG0021385	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	118530175	C	C	118530175	3	2	260	1	0	0	0	0	1	0	0	0	16466	1667	58	4	430	4	TREH	11	118530175	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08	740775	118530175	16476341	59	18668											
CCND2	894	broad.mit.edu	37	chr12	4398029	4398029	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctttaagtttgccatgtaccCaccgtcgatgatcgcaactg	8	12	0	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr12:4398029C>G	uc001qmo.2	+	4	898	c.593C>G	c.(592-594)CCA>CGA	p.P198R		NM_001759	NP_001750	P30279	CCND2_HUMAN	cyclin D2	198					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|breast(1)|kidney(1)	3			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			GCCATGTACCCACCGTCGATG	0.547			T	IGL@	NHL,CLL								G	4398029	G	G	4398029	3	3	260	1	0	0	0	0	1	0	0	0	2917	594	21	5	607	5	CCND2	12	4398029	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08		4398029	129453866	60	18669											
ACSM4	341392	broad.mit.edu	37	chr12	7470689	7470689	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acacgggctgggtcaaggccGccattggcagtgtgttttct	14	10	2	0	rs79217312		TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr12:7470689G>A	uc001qsx.1	+	5	832	c.832G>A	c.(832-834)GCC>ACC	p.A278T		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	278					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						GGTCAAGGCCGCCATTGGCAG	0.458													A	7470689	A	A	7470689	3	1	260	1	0	0	0	0	1	0	0	0	186	1087	38	1	850	1	ACSM4	12	7470689	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	3072660	7470689	126381206	61	18670											
MRPS35	60488	broad.mit.edu	37	chr12	27908375	27908375	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtgaagagactattaaatGtgacatgaattatggagtag	11	4	0	4			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr12:27908375G>A	uc001rih.2	+	8	1012	c.964G>A	c.(964-966)GTG>ATG	p.V322M	MRPS35_uc001rii.2_3'UTR	NM_021821	NP_068593	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35 precursor	322					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit					0	Lung SC(9;0.0873)					ACTATTAAATGTGACATGAAT	0.254													A	27908375	A	A	27908375	3	1	260	1	0	0	0	0	1	0	0	0	9844	1377	48	3	994	3	MRPS35	12	27908375	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	20437686	27908375	105943520	62	18671											
GLI1	2735	broad.mit.edu	37	chr12	57864118	57864118	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggtaccactgtgtcccgccGcgtgggccccccagtctctc	11	18	1	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr12:57864118G>A	uc001snx.2	+	12	1673	c.1595G>A	c.(1594-1596)CGC>CAC	p.R532H	GLI1_uc009zpq.2_Missense_Mutation_p.R404H	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	532					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			GTGTCCCGCCGCGTGGGCCCC	0.602													A	57864118	A	A	57864118	3	1	260	1	0	0	0	0	1	0	0	0	6437	1087	38	1	1637	1	GLI1	12	57864118	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	29955743	57864118	75987777	63	18672											
SLC6A15	55117	broad.mit.edu	37	chr12	85270346	85270346	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	atgctctgatgaggaagcaaAtaagtaccacatatggaaac	9	7	1	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr12:85270346A>T	uc001szv.2	-	6	1290	c.797T>A	c.(796-798)ATT>AAT	p.I266N	SLC6A15_uc010sul.1_Missense_Mutation_p.I159N	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	266	Helical; Name=5; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						GAGGAAGCAAATAAGTACCAC	0.303													T	85270346	T	T	85270346	3	4	260	1	0	0	0	0	1	0	0	0	14678	101	4	5	1423	5	SLC6A15	12	85270346	Missense_Mutation	SNP	A	TCGA-76-4928-01B-01D-1486-08	27406228	85270346	48581549	64	18673											
ATP12A	479	broad.mit.edu	37	chr13	25263441	25263441	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtctggtggtcattttaacGgggatctttgcttattacca	11	7	3	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr13:25263441G>A	uc001upp.2	+	5	661	c.474G>A	c.(472-474)ACG>ACA	p.T158T	ATP12A_uc010aaa.2_Silent_p.T158T	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	158	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TCATTTTAACGGGGATCTTTG	0.537													A	25263441	A	A	25263441	2	1	260	1	0	0	0	0	0	0	0	1	1122	1103	39	2		2	ATP12A	13	25263441	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08		25263441	89906437	65	18674											
TTC5	91875	broad.mit.edu	37	chr14	20767565	20767565	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtgtcagtccgcagctgacGaagcaccattgacaggtttt	11	10	1	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr14:20767565G>A	uc001vwt.2	-	4	496	c.439C>T	c.(439-441)CGT>TGT	p.R147C	TTC5_uc001vwu.2_Missense_Mutation_p.R4C	NM_138376	NP_612385	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	147					DNA repair	cytoplasm|nucleus	binding			ovary(1)	1	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		CGCAGCTGACGAAGCACCATT	0.493													A	20767565	A	A	20767565	3	1	260	1	0	0	0	0	1	0	0	0	16708	1058	37	2	911	2	TTC5	14	20767565	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08		20767565	86581975	66	18675											
ISM2	145501	broad.mit.edu	37	chr14	77948978	77948978	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacaggtctatcgacacctcGgcctgggggtcctccaccac	10	16	1	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr14:77948978G>A	uc001xtz.2	-	4	734	c.660C>T	c.(658-660)GCC>GCT	p.A220A	ISM2_uc001xua.2_Intron|ISM2_uc001xty.2_Silent_p.A132A|ISM2_uc010tvl.1_Silent_p.A139A	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	220						extracellular region				skin(1)	1						TCGACACCTCGGCCTGGGGGT	0.622													A	77948978	A	A	77948978	2	1	260	1	0	0	0	0	0	0	0	1	7861	1103	39	2		2	ISM2	14	77948978	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08	57181413	77948978	29400562	67	18676											
UNC13C	440279	broad.mit.edu	37	chr15	54542603	54542603	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agtgtggagtgaaatgccacGaaaagtgtcaggacctgcta	13	7	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr15:54542603G>A	uc002ack.2	+	6	3409	c.3409G>A	c.(3409-3411)GAA>AAA	p.E1137K		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1137	Phorbol-ester/DAG-type.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GAAATGCCACGAAAAGTGTCA	0.507													A	54542603	A	A	54542603	3	1	260	1	0	0	0	0	1	0	0	0	16983	1059	37	2	3431	2	UNC13C	15	54542603	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08		54542603	47988789	68	18677											
IGDCC3	9543	broad.mit.edu	37	chr15	65667680	65667680	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagcactataggctgcccgGggacggcaacatcatcactt	10	14	2	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr15:65667680G>A	uc002aos.2	-	2	416	c.164C>T	c.(163-165)CCC>CTC	p.P55L		NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	55	Extracellular (Potential).|Ig-like C2-type 1.									ovary(3)	3						AGGCTGCCCGGGGACGGCAAC	0.582													A	65667680	A	A	65667680	3	1	260	1	0	0	0	0	1	0	0	0	7568	1232	43	3	2332	3	IGDCC3	15	65667680	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	11125077	65667680	36863712	69	18678											
GRIN2A	2903	broad.mit.edu	37	chr16	9857171	9857171	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgactgtccctggaacagtaCgatgccgttgacctcaagga	11	12	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr16:9857171C>T	uc002czo.3	-	13	4778	c.4230G>A	c.(4228-4230)TCG>TCA	p.S1410S	GRIN2A_uc010uym.1_Silent_p.S1410S|GRIN2A_uc010uyn.1_3'UTR|GRIN2A_uc002czr.3_3'UTR	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1410	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGAACAGTACGATGCCGTTG	0.502													T	9857171	T	T	9857171	2	4	260	1	0	0	0	0	0	0	0	1	6779	523	19	1		1	GRIN2A	16	9857171	Silent	SNP	C	TCGA-76-4928-01B-01D-1486-08		9857171	80497582	70	18679											
HYDIN	54768	broad.mit.edu	37	chr16	70917889	70917889	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtggactgcagggtctcggcCggagatatcgatggctataa	15	8	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr16:70917889C>T	uc002ezr.2	-	59	10038	c.9910G>A	c.(9910-9912)GGC>AGC	p.G3304S		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3305										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GGGTCTCGGCCGGAGATATCG	0.532													T	70917889	T	T	70917889	3	4	260	1	0	0	0	0	1	0	0	0	7467	652	23	2	5564	2	HYDIN	16	70917889	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	61060718	70917889	19436864	71	18680											
EIF4A1	1973	broad.mit.edu	37	chr17	7480924	7480924	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	actatgtgacttgtatgaaaCcctgaccatcacccaggcag	8	12	1	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr17:7480924C>A	uc002gho.1	+	16	2131	c.806C>A	c.(805-807)ACC>AAC	p.T269N	EIF4A1_uc002ghr.1_Missense_Mutation_p.T269N|EIF4A1_uc002ghq.1_Missense_Mutation_p.T269N|EIF4A1_uc002ghp.1_Missense_Mutation_p.T269N|SNORA67_uc010cml.1_5'Flank|CD68_uc002ghv.2_5'Flank|CD68_uc002ghu.2_5'Flank	NM_001416	NP_001407	P60842	IF4A1_HUMAN	eukaryotic translation initiation factor 4A	269	Helicase C-terminal.				nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA cap binding|translation initiation factor activity			ovary(1)	1						TTGTATGAAACCCTGACCATC	0.537													A	7480924	A	A	7480924	3	1	260	1	0	0	0	0	1	0	0	0	5024	507	18	5	836	5	EIF4A1	17	7480924	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08		7480924	73714286	72	18681											
PIK3R6	146850	broad.mit.edu	37	chr17	8741187	8741187	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccggaggtcctggctttccGcctggaaaacaggagatcac	13	12	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr17:8741187G>A	uc002glq.1	-	5	431	c.191C>T	c.(190-192)GCG>GTG	p.A64V	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	64					platelet activation	cytosol					0						CTGGCTTTCCGCCTGGAAAAC	0.587													A	8741187	A	A	8741187	3	1	260	1	0	0	0	0	1	0	0	0	11923	1101	38	1	2136	1	PIK3R6	17	8741187	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	1260263	8741187	72454023	73	18682											
MYH8	4626	broad.mit.edu	37	chr17	10316043	10316043	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagataggctgccttgtcagCgactgcagagacacagttca	12	10	2	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr17:10316043C>T	uc002gmm.2	-	13	1245	c.1150G>A	c.(1150-1152)GCT>ACT	p.A384T	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	384	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GCCTTGTCAGCGACTGCAGAG	0.423									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				T	10316043	T	T	10316043	3	4	260	1	0	0	0	0	1	0	0	0	10041	768	27	1	4775	1	MYH8	17	10316043	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	1574856	10316043	70879167	74	18683											
CPD	1362	broad.mit.edu	37	chr17	28772878	28772881	+	Frame_Shift_Del	DEL	TTAA	-	-													ctactaaagagtttgaaactTtaattaaagacctttcagcg							TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr17:28772878_28772881delTTAA	uc002hfb.1	+	12	2728_2731	c.2713_2716delTTAA	c.(2713-2718)TTAATTfs	p.L905fs	CPD_uc010wbo.1_Frame_Shift_Del_p.L658fs|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	905_906	Extracellular (Potential).|Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						GTTTGAAACTTTAATTAAAGACCT	0.417													-	28772881	-	-	28772878	7	5	260	1	0	1	0	1	0	0	0	0	3798	1838	64	0	2759	0	CPD	17	28772878	Frame_Shift_Del	DEL	TTAA	TCGA-76-4928-01B-01D-1486-08	18456835	28772878	52422332	75	18684											
ORMDL3	94103	broad.mit.edu	37	chr17	38080398	38080398	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtaggagagccagatgccaCggctgttcatcacccgcgtg	13	13	2	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr17:38080398C>T	uc002htj.1	-	2	199	c.59G>A	c.(58-60)CGT>CAT	p.R20H	ORMDL3_uc002hti.1_RNA|ORMDL3_uc002htk.1_Missense_Mutation_p.R20H	NM_139280	NP_644809	Q8N138	ORML3_HUMAN	ORM1-like 3	20	Cytoplasmic (Potential).				ceramide metabolic process	integral to membrane|SPOTS complex	protein binding				0	Colorectal(19;0.000442)		Lung(15;0.0234)			CCAGATGCCACGGCTGTTCAT	0.602													T	38080398	T	T	38080398	3	4	260	1	0	0	0	0	1	0	0	0	11271	536	19	1	414	1	ORMDL3	17	38080398	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	9307520	38080398	43114812	76	18685											
CNTNAP1	8506	broad.mit.edu	37	chr17	40837035	40837035	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttggtaacgtgaacgagtcGgcggtggtgcgccatgacct	15	9	0	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr17:40837035G>A	uc002iay.2	+	4	606	c.390G>A	c.(388-390)TCG>TCA	p.S130S	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	130	Extracellular (Potential).|F5/8 type C.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		TGAACGAGTCGGCGGTGGTGC	0.478													A	40837035	A	A	40837035	2	1	260	1	0	0	0	0	0	0	0	1	3646	1103	39	2		2	CNTNAP1	17	40837035	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08	2756637	40837035	40358175	77	18686											
WIPI1	55062	broad.mit.edu	37	chr17	66449078	66449078	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtggacttgatccagctgctCcacagaactcagagaaaaca	9	11	1	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr17:66449078C>T	uc010dey.2	-	2	227	c.136G>A	c.(136-138)GAG>AAG	p.E46K	WIPI1_uc002jhd.3_RNA|WIPI1_uc010wqo.1_Intron|WIPI1_uc002jhe.3_Intron	NM_017983	NP_060453	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting	46					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding				0						TCCAGCTGCTCCACAGAACTC	0.488													T	66449078	T	T	66449078	3	4	260	1	0	0	0	0	1	0	0	0	17367	864	30	3	1252	3	WIPI1	17	66449078	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	25612043	66449078	14746132	78	18687											
GPR142	350383	broad.mit.edu	37	chr17	72368095	72368095	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accacgcctcagtctggatcGccatcctgctcacggttgac	9	16	3	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr17:72368095G>A	uc010wqy.1	+	4	745	c.745G>A	c.(745-747)GCC>ACC	p.A249T	GPR142_uc010wqx.1_Missense_Mutation_p.A161T	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	249	Helical; Name=3; (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AGTCTGGATCGCCATCCTGCT	0.692													A	72368095	A	A	72368095	3	1	260	1	0	0	0	0	1	0	0	0	6650	1087	38	1	759	1	GPR142	17	72368095	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	5919017	72368095	8827115	79	18688											
ST8SIA5	29906	broad.mit.edu	37	chr18	44260035	44260035	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcaggtgcccgtgtgcacGcggaggatgcctcggctgtg	17	12	0	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr18:44260035G>A	uc002lcj.1	-	7	1669	c.1101C>T	c.(1099-1101)CGC>CGT	p.R367R	ST8SIA5_uc002lci.1_Silent_p.R214R|ST8SIA5_uc010xcy.1_Silent_p.R403R|ST8SIA5_uc010xcz.1_Silent_p.R336R	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	367	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						CCGTGTGCACGCGGAGGATGC	0.652													A	44260035	A	A	44260035	2	1	260	1	0	0	0	0	0	0	0	1	15234	1074	38	1		1	ST8SIA5	18	44260035	Silent	SNP	G	TCGA-76-4928-01B-01D-1486-08		44260035	33817213	80	18689											
CDH7	1005	broad.mit.edu	37	chr18	63430143	63430143	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	agctcttttcctgtgtttttCtgggatgagtcaagcagaac	10	8	3	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr18:63430143C>T	uc002ljz.2	+	2	390	c.65C>T	c.(64-66)TCT>TTT	p.S22F	CDH7_uc002lka.2_Missense_Mutation_p.S22F|CDH7_uc002lkb.2_Missense_Mutation_p.S22F	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	22					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CTGTGTTTTTCTGGGATGAGT	0.433													T	63430143	T	T	63430143	3	4	260	1	0	0	0	0	1	0	0	0	3115	913	32	3	67	3	CDH7	18	63430143	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	19170108	63430143	14647105	81	18690											
KLK15	55554	broad.mit.edu	37	chr19	51330305	51330305	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcaacatgatgtcgttgcGgtggctgcgcgcttcgtagc	14	11	0	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr19:51330305G>A	uc002ptl.2	-	3	341	c.310C>T	c.(310-312)CGC>TGC	p.R104C	KLK15_uc002ptm.2_Missense_Mutation_p.R104C|KLK15_uc002ptn.2_Missense_Mutation_p.R104C|KLK15_uc002pto.2_Missense_Mutation_p.R103C|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_Missense_Mutation_p.R103C|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	104	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		ATGTCGTTGCGGTGGCTGCGC	0.697													A	51330305	A	A	51330305	3	1	260	1	0	0	0	0	1	0	0	0	8403	1116	39	2	472	2	KLK15	19	51330305	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08		51330305	7798678	82	18691											
NLRP5	126206	broad.mit.edu	37	chr19	56539657	56539657	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accccaggagacaccctggaCgccttccactgtcttttcga	8	16	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr19:56539657C>T	uc002qmj.2	+	7	2058	c.2058C>T	c.(2056-2058)GAC>GAT	p.D686D	NLRP5_uc002qmi.2_Silent_p.D667D	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	686						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		ACACCCTGGACGCCTTCCACT	0.542													T	56539657	T	T	56539657	2	4	260	1	0	0	0	0	0	0	0	1	10480	535	19	1		1	NLRP5	19	56539657	Silent	SNP	C	TCGA-76-4928-01B-01D-1486-08	5209352	56539657	2589326	83	18692											
TGM3	7053	broad.mit.edu	37	chr20	2312692	2312692	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccaaaaggctttggggaaaCttaaacccaacacgccattt	7	11	0	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr20:2312692C>T	uc002wfx.3	+	10	1475	c.1378C>T	c.(1378-1380)CTT>TTT	p.L460F		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	460					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	TTTGGGGAAACTTAAACCCAA	0.522													T	2312692	T	T	2312692	3	4	260	1	0	0	0	0	1	0	0	0	15828	565	20	3	1416	3	TGM3	20	2312692	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08		2312692	60712828	84	18693											
RPRD1B	58490	broad.mit.edu	37	chr20	36687859	36687859	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcaggggatgctactgtcCgacagaaaattgcttctctg	10	10	2	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr20:36687859C>T	uc002xho.3	+	5	994	c.592C>T	c.(592-594)CGA>TGA	p.R198*		NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	198										pancreas(1)	1						TGCTACTGTCCGACAGAAAAT	0.433													T	36687859	T	T	36687859	4	4	260	1	0	0	0	0	0	1	0	0	13616	644	23	2	610	2	RPRD1B	20	36687859	Nonsense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	34375167	36687859	26337661	85	18694											
LBP	3929	broad.mit.edu	37	chr20	36995435	36995435	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	accgcctgactctaatatccGactgaccaccaagtccttcc	5	17	1	2			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr20:36995435G>A	uc002xic.1	+	9	979	c.944G>A	c.(943-945)CGA>CAA	p.R315Q		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	315					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				TCTAATATCCGACTGACCACC	0.537													A	36995435	A	A	36995435	3	1	260	1	0	0	0	0	1	0	0	0	8651	1058	37	2	978	2	LBP	20	36995435	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	307576	36995435	26030085	86	18695											
CHD6	84181	broad.mit.edu	37	chr20	40065924	40065924	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tttgactcaccgtttgtttcTggaggccatctactttgtcc	8	11	3	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr20:40065924T>G	uc002xka.1	-	27	4236	c.4058A>C	c.(4057-4059)CAG>CCG	p.Q1353P	CHD6_uc002xkb.1_Missense_Mutation_p.Q119P	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1353					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CGTTTGTTTCTGGAGGCCATC	0.358													G	40065924	G	G	40065924	3	3	260	1	0	0	0	0	1	0	0	0	3329	1580	55	5	4133	5	CHD6	20	40065924	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08	3070489	40065924	22959596	87	18696											
KCNB1	3745	broad.mit.edu	37	chr20	48098620	48098620	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctggtggtagcgggcctggCagcaggactccaggtagatc	16	10	1	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr20:48098620C>T	uc002xur.1	-	1	562	c.398G>A	c.(397-399)TGC>TAC	p.C133Y	KCNB1_uc002xus.1_Missense_Mutation_p.C133Y	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	133	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GCGGGCCTGGCAGCAGGACTC	0.607													T	48098620	T	T	48098620	3	4	260	1	0	0	0	0	1	0	0	0	8012	710	25	3	2186	3	KCNB1	20	48098620	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	8032696	48098620	14926900	88	18697											
KRTAP20-2	337976	broad.mit.edu	37	chr21	32007616	32007616	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaactactatggtggtctgCgttatggctatggagtcctg	13	8	1	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr21:32007616C>T	uc011adg.1	+	1	34	c.34C>T	c.(34-36)CGT>TGT	p.R12C		NM_181616	NP_853647	Q3LI61	KR202_HUMAN	keratin associated protein 20-2	12						intermediate filament				central_nervous_system(1)	1						TGGTGGTCTGCGTTATGGCTA	0.517													T	32007616	T	T	32007616	3	4	260	1	0	0	0	0	1	0	0	0	8537	768	27	1	36	1	KRTAP20-2	21	32007616	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08		32007616	16122279	89	18698											
POTEH	23784	broad.mit.edu	37	chr22	16279238	16279238	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taaatttgcttttttcttgaTtaaaaatttcaccacttgct	3	7	2	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr22:16279238T>C	uc010gqp.2	-	4	1037	c.985A>G	c.(985-987)ATC>GTC	p.I329V	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.I48V|POTEH_uc002zlj.1_Missense_Mutation_p.I164V	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	329	ANK 5.									skin(1)	1						TTTTTCTTGATTAAAAATTTC	0.338													C	16279238	C	C	16279238	3	2	260	1	0	0	0	0	1	0	0	0	12267	1493	52	4	680	4	POTEH	22	16279238	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08		16279238	35025328	90	18699											
PRODH	5625	broad.mit.edu	37	chr22	18912582	18912582	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgaggcttcgatgcagcGcaagaatgtctccatgtggc	12	11	1	2	rs147270439		TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr22:18912582G>A	uc010grl.2	-	4	663	c.649C>T	c.(649-651)CGC>TGC	p.R217C	PRODH_uc002zoj.3_Missense_Mutation_p.R107C|PRODH_uc002zol.3_Missense_Mutation_p.R107C|PRODH_uc002zok.3_Missense_Mutation_p.R217C	NM_016335	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase 1	217					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)	1					L-Proline(DB00172)	TCGATGCAGCGCAAGAATGTC	0.632													A	18912582	A	A	18912582	3	1	260	1	0	0	0	0	1	0	0	0	12548	1087	38	1	1197	1	PRODH	22	18912582	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08	2633344	18912582	32391984	91	18700											
MAPK1	5594	broad.mit.edu	37	chr22	22142632	22142632	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aatagttcctagcttttaaaTttattatacaattcaggtct	4	6	2	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr22:22142632T>C	uc002zvn.2	-	6	1010	c.770A>G	c.(769-771)AAT>AGT	p.N257S	MAPK1_uc002zvo.2_Missense_Mutation_p.N257S|MAPK1_uc010gtk.1_Intron	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	257	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	AGCTTTTAAATTTATTATACA	0.353													C	22142632	C	C	22142632	3	2	260	1	0	0	0	0	1	0	0	0	9271	1493	52	4	324	4	MAPK1	22	22142632	Missense_Mutation	SNP	T	TCGA-76-4928-01B-01D-1486-08	3230050	22142632	29161934	92	18701											
TMPRSS6	164656	broad.mit.edu	37	chr22	37470715	37470715	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacaggcagggacacagagtCcattcacagaacagaggaac	11	11	1	3			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chr22:37470715C>T	uc003aqs.1	-	12	1517	c.1403G>A	c.(1402-1404)GGA>GAA	p.G468E	TMPRSS6_uc003aqt.1_Missense_Mutation_p.G459E	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	468	LDL-receptor class A 1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						GACACAGAGTCCATTCACAGA	0.632													T	37470715	T	T	37470715	3	4	260	1	0	0	0	0	1	0	0	0	16248	855	30	3	1060	3	TMPRSS6	22	37470715	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	15328083	37470715	13833851	93	18702											
ARSF	416	broad.mit.edu	37	chrX	3021841	3021841	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgggaaggtggaatccgcGtcccaggaattgtccgatgg	16	9	0	0			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chrX:3021841G>A	uc004cre.1	+	9	1362	c.1141G>A	c.(1141-1143)GTC>ATC	p.V381I	ARSF_uc004crf.1_Missense_Mutation_p.V381I	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	381						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGGAATCCGCGTCCCAGGAAT	0.438													A	3021841	A	A	3021841	3	1	260	1	0	0	0	0	1	0	0	0	991	1145	40	1	1171	1	ARSF	23	3021841	Missense_Mutation	SNP	G	TCGA-76-4928-01B-01D-1486-08		3021841	152248719	94	18703											
BRWD3	254065	broad.mit.edu	37	chrX	79999713	79999713	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgtagcaagaaggcgtccatCatctgtagcccaaattttta	8	9	2	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chrX:79999713C>T	uc004edt.2	-	8	894	c.631G>A	c.(631-633)GAT>AAT	p.D211N	BRWD3_uc004edo.2_5'UTR|BRWD3_uc004edp.2_Missense_Mutation_p.D40N|BRWD3_uc004edq.2_5'UTR|BRWD3_uc010nmj.1_5'UTR|BRWD3_uc004edr.2_5'UTR|BRWD3_uc004eds.2_5'UTR|BRWD3_uc004edu.2_5'UTR|BRWD3_uc004edv.2_5'UTR|BRWD3_uc004edw.2_5'UTR|BRWD3_uc004edx.2_5'UTR|BRWD3_uc004edy.2_5'UTR|BRWD3_uc004edz.2_5'UTR|BRWD3_uc004eea.2_5'UTR|BRWD3_uc004eeb.2_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	211	WD 2.									ovary(4)	4						AGGCGTCCATCATCTGTAGCC	0.403													T	79999713	T	T	79999713	3	4	260	1	0	0	0	0	1	0	0	0	1526	826	29	3	4913	3	BRWD3	23	79999713	Missense_Mutation	SNP	C	TCGA-76-4928-01B-01D-1486-08	76977872	79999713	75270847	95	18704											
FATE1	89885	broad.mit.edu	37	chrX	150885868	150885868	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	actgccacccgacccaagaaAatggtactgtatggggtcct	10	12	0	1			TCGA-76-4928-01B-01D-1486-08	TCGA-76-4928-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e30f277-875e-4ab8-bc7c-0a5121cde6d1	245a59f0-a6c4-4e1a-bd0a-d104308b123c	g.chrX:150885868A>T	uc004fex.2	+	2	315	c.231A>T	c.(229-231)AAA>AAT	p.K77N		NM_033085	NP_149076	Q969F0	FATE1_HUMAN	fetal and adult testis expressed transcript	77						endoplasmic reticulum|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GACCCAAGAAAATGGTACTGT	0.562													T	150885868	T	T	150885868	3	4	260	1	0	0	0	0	1	0	0	0	5693	11	1	5	237	5	FATE1	23	150885868	Missense_Mutation	SNP	A	TCGA-76-4928-01B-01D-1486-08	70886155	150885868	4384692	96	18705											
TNFRSF4	7293	broad.mit.edu	37	chr1	1147004	1147004	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggtccggaaactgcctccCcctggggaggaaaaaaggag	16	10	0	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr1:1147004C>T	uc001ade.2	-	7	770	c.765G>A	c.(763-765)GGG>GGA	p.G255G	TNFRSF4_uc001adf.2_Silent_p.G285G	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	255	Cytoplasmic (Potential).				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AACTGCCTCCCCCTGGGGAGG	0.677													T	1147004	T	T	1147004	2	4	261	1	0	0	0	0	0	0	0	1	16294	637	22	3		3	TNFRSF4	1	1147004	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08		1147004	248103617	1	18706											
PABPC4	8761	broad.mit.edu	37	chr1	40030160	40030160	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taccagttggagccagatggCgaagagttggacgaggccca	15	9	0	2	rs139185037		TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr1:40030160C>T	uc010oiv.1	-	10	2286	c.1388G>A	c.(1387-1389)CGC>CAC	p.R463H	PABPC4_uc001cdl.2_Missense_Mutation_p.R463H|PABPC4_uc001cdm.2_Missense_Mutation_p.R463H	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	463					blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AGCCAGATGGCGAAGAGTTGG	0.542													T	40030160	T	T	40030160	3	4	261	1	0	0	0	0	1	0	0	0	11366	768	27	1	618	1	PABPC4	1	40030160	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	38883156	40030160	209220461	2	18707											
CASQ1	844	broad.mit.edu	37	chr1	160162639	160162639	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ggtgttggcttcgggctggtAgactctgagaaggatgcagc	17	7	1	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr1:160162639A>T	uc010pja.1	+	2	584	c.327A>T	c.(325-327)GTA>GTT	p.V109V		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	109						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCGGGCTGGTAGACTCTGAGA	0.522											OREG0013927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	160162639	T	T	160162639	2	4	261	1	0	0	0	0	0	0	0	1	2680	407	15	5		5	CASQ1	1	160162639	Silent	SNP	A	TCGA-76-4929-01A-01D-1486-08	120132479	160162639	89087982	3	18708											
TNFSF18	8995	broad.mit.edu	37	chr1	173010533	173010533	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatgaattggggatttgctaGtaaaatgataccccagtatg	11	5	0	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr1:173010533G>A	uc001giu.2	-	3	575	c.574C>T	c.(574-576)CTA>TTA	p.L192L		NM_005092	NP_005083	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily,	192	Extracellular (Potential).				anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						GGATTTGCTAGTAAAATGATA	0.418													A	173010533	A	A	173010533	2	1	261	1	0	0	0	0	0	0	0	1	16306	1020	36	3		3	TNFSF18	1	173010533	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08	12847894	173010533	76240088	4	18709											
LHX9	56956	broad.mit.edu	37	chr1	197887088	197887088	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcagatccaagactgaggcCcgtctggccaaaggcgccca	12	15	1	3			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr1:197887088C>T	uc001guk.1	+	1	572	c.135C>T	c.(133-135)GCC>GCT	p.A45A	LHX9_uc009wzc.1_RNA|LHX9_uc001gui.1_Silent_p.A36A|LHX9_uc001guj.1_Silent_p.A51A	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	45					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						AGACTGAGGCCCGTCTGGCCA	0.662													T	197887088	T	T	197887088	2	4	261	1	0	0	0	0	0	0	0	1	8777	610	22	3		3	LHX9	1	197887088	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	24876555	197887088	51363533	5	18710											
HADHA	3030	broad.mit.edu	37	chr2	26457099	26457099	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctatacctcaagtcctcctcCcaggcaggatccattgatgg	8	14	1	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr2:26457099C>T	uc002rgy.2	-	5	569	c.439G>A	c.(439-441)GGA>AGA	p.G147R	HADHA_uc010yks.1_Missense_Mutation_p.G60R|HADHA_uc010ykt.1_Missense_Mutation_p.G60R	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	147					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	AGTCCTCCTCCCAGGCAGGAT	0.433													T	26457099	T	T	26457099	3	4	261	1	0	0	0	0	1	0	0	0	6943	632	22	3	1916	3	HADHA	2	26457099	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08		26457099	216742274	6	18711											
FAM123C	205147	broad.mit.edu	37	chr2	131520666	131520666	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggacagacagggaccaatccCggctggacacagctgggctc	14	13	0	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr2:131520666C>T	uc002trw.2	+	2	1211	c.1021C>T	c.(1021-1023)CGG>TGG	p.R341W	FAM123C_uc010fmv.2_Missense_Mutation_p.R341W|FAM123C_uc010fms.1_Missense_Mutation_p.R341W|FAM123C_uc010fmt.1_Missense_Mutation_p.R341W|FAM123C_uc010fmu.1_Missense_Mutation_p.R341W	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	341										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GGACCAATCCCGGCTGGACAC	0.667													T	131520666	T	T	131520666	3	4	261	1	0	0	0	0	1	0	0	0	5424	643	23	2	1023	2	FAM123C	2	131520666	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	105063567	131520666	111678707	7	18712											
PHOSPHO2	493911	broad.mit.edu	37	chr2	170558142	170558142	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atcttgagcctatggaatatTctgttgtagtttggtcctca	9	7	3	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr2:170558142T>C	uc002ufg.2	+	4	1049	c.661T>C	c.(661-663)TCT>CCT	p.S221P	KLHL23_uc002ufh.1_Intron	NM_001008489	NP_001008489	Q8TCD6	PHOP2_HUMAN	phosphatase, orphan 2	221							metal ion binding|pyridoxal phosphatase activity			skin(1)	1						TATGGAATATTCTGTTGTAGT	0.308													C	170558142	C	C	170558142	3	2	261	1	0	0	0	0	1	0	0	0	11857	1783	62	4	663	4	PHOSPHO2	2	170558142	Missense_Mutation	SNP	T	TCGA-76-4929-01A-01D-1486-08	39037476	170558142	72641231	8	18713											
MYO1B	4430	broad.mit.edu	37	chr2	192248067	192248067	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catttgtgacctaatagaaaAtgtgagtacttaggtacagt	9	5	0	3			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr2:192248067A>T	uc010fsg.2	+	15	1607	c.1352A>T	c.(1351-1353)AAT>ATT	p.N451I	MYO1B_uc002usq.2_Missense_Mutation_p.N451I|MYO1B_uc002usr.2_Missense_Mutation_p.N451I|MYO1B_uc002ust.1_Missense_Mutation_p.N89I	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	451	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			CTAATAGAAAATGTGAGTACT	0.313													T	192248067	T	T	192248067	3	4	261	1	0	0	0	0	1	0	0	0	10069	115	4	5	1406	5	MYO1B	2	192248067	Missense_Mutation	SNP	A	TCGA-76-4929-01A-01D-1486-08	21689925	192248067	50951306	9	18714											
ALS2	57679	broad.mit.edu	37	chr2	202609022	202609022	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gaatctgagatttgatatcaCttagttttgaatagaatcgt	8	4	2	4			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr2:202609022C>G	uc002uyo.2	-	10	2485	c.2129G>C	c.(2128-2130)AGT>ACT	p.S710T	ALS2_uc002uyp.3_Missense_Mutation_p.S710T|ALS2_uc002uyq.2_Missense_Mutation_p.S710T|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	710	DH.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TTTGATATCACTTAGTTTTGA	0.398													G	202609022	G	G	202609022	3	3	261	1	0	0	0	0	1	0	0	0	550	565	20	5	2944	5	ALS2	2	202609022	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	10360955	202609022	40590351	10	18715											
SLC11A1	6556	broad.mit.edu	37	chr2	219254613	219254613	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcgagagatagaccgggcCcgccgagcagacatcagaga	13	12	2	4			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr2:219254613C>T	uc002vhv.2	+	9	1156	c.816C>T	c.(814-816)GCC>GCT	p.A272A	SLC11A1_uc010fvp.1_Silent_p.A272A|SLC11A1_uc010fvq.1_Silent_p.A205A|SLC11A1_uc010zkc.1_Silent_p.A205A|SLC11A1_uc002vhu.1_Silent_p.A67A|SLC11A1_uc002vhw.2_Silent_p.A154A|SLC11A1_uc010fvr.2_Silent_p.A67A	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	272	Cytoplasmic (Potential).				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAGACCGGGCCCGCCGAGCAG	0.537													T	219254613	T	T	219254613	2	4	261	1	0	0	0	0	0	0	0	1	14380	610	22	3		3	SLC11A1	2	219254613	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	16645591	219254613	23944760	11	18716											
RNF123	63891	broad.mit.edu	37	chr3	49737157	49737157	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggttgcggggccagcccacCgtcctcctcacactggccca	11	19	1	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr3:49737157C>T	uc003cxh.2	+	12	1022	c.936C>T	c.(934-936)ACC>ACT	p.T312T	RNF123_uc010hky.1_5'UTR|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	312						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GCCAGCCCACCGTCCTCCTCA	0.647													T	49737157	T	T	49737157	2	4	261	1	0	0	0	0	0	0	0	1	13433	639	23	2		2	RNF123	3	49737157	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08		49737157	148285273	12	18717											
ALG3	10195	broad.mit.edu	37	chr3	183962404	183962404	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggtacctgaaggccagcacaGattcccagcttggggagggc	15	11	0	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr3:183962404G>A	uc003fne.2	-	5	742	c.711C>T	c.(709-711)ATC>ATT	p.I237I	ALG3_uc011brc.1_Silent_p.I202I|ALG3_uc011brd.1_Silent_p.I181I|ALG3_uc011bre.1_Silent_p.I189I|ALG3_uc003fnf.1_Silent_p.I197I	NM_005787	NP_005778	Q92685	ALG3_HUMAN	alpha-1,3-mannosyltransferase ALG3 isoform a	237	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity				0	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCCAGCACAGATTCCCAGCT	0.537													A	183962404	A	A	183962404	2	1	261	1	0	0	0	0	0	0	0	1	520	932	33	3		3	ALG3	3	183962404	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08	134225247	183962404	14060026	13	18718											
PDGFRA	5156	broad.mit.edu	37	chr4	55131090	55131090	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgttcttttttatagcaacAtcagagctggatctagaaat	7	6	3	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr4:55131090A>G	uc003han.3	+	5	964	c.633A>G	c.(631-633)ACA>ACG	p.T211T	PDGFRA_uc003haa.2_Intron|PDGFRA_uc003hal.2_3'UTR|PDGFRA_uc010igq.1_Silent_p.T105T|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	211	Ig-like C2-type 3.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TTATAGCAACATCAGAGCTGG	0.373			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			G	55131090	G	G	55131090	2	3	261	1	0	0	0	0	0	0	0	1	11661	204	8	4		4	PDGFRA	4	55131090	Silent	SNP	A	TCGA-76-4929-01A-01D-1486-08		55131090	136023186	14	18719											
LPHN3	23284	broad.mit.edu	37	chr4	62363023	62363023	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagacagccatgtggccatcGcagctactaattttcatgat	8	10	1	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr4:62363023G>A	uc010ihh.2	+	1	185	c.12G>A	c.(10-12)TCG>TCA	p.S4S	LPHN3_uc003hcq.3_Silent_p.S4S|LPHN3_uc010ihg.1_Silent_p.S4S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	4					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TGTGGCCATCGCAGCTACTAA	0.348													A	62363023	A	A	62363023	2	1	261	1	0	0	0	0	0	0	0	1	8917	1074	38	1		1	LPHN3	4	62363023	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08	7231933	62363023	128791253	15	18720											
DCK	1633	broad.mit.edu	37	chr4	71888254	71888254	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagaaacctgtattatttttTgaacgatctgtgtatagtga	9	4	1	3			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr4:71888254T>G	uc003hfx.2	+	3	666	c.378T>G	c.(376-378)TTT>TTG	p.F126L	DCK_uc011cbb.1_Missense_Mutation_p.F54L	NM_000788	NP_000779	P27707	DCK_HUMAN	deoxycytidine kinase	126					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			ovary(1)	1			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	TATTATTTTTTGAACGATCTG	0.358													G	71888254	G	G	71888254	3	3	261	1	0	0	0	0	1	0	0	0	4290	1809	63	5	388	5	DCK	4	71888254	Missense_Mutation	SNP	T	TCGA-76-4929-01A-01D-1486-08	9525231	71888254	119266022	16	18721											
ANXA3	306	broad.mit.edu	37	chr4	79507428	79507428	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttagggcgcgggaacaaaCgaagatgccttgattgaaat	12	6	0	3	rs144437584		TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr4:79507428C>T	uc003hld.2	+	6	637	c.327C>T	c.(325-327)AAC>AAT	p.N109N	ANXA3_uc003hle.2_Silent_p.N70N|ANXA3_uc010ijk.2_Silent_p.N70N	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	109	Annexin 2.				defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						CGGGAACAAACGAAGATGCCT	0.343													T	79507428	T	T	79507428	2	4	261	1	0	0	0	0	0	0	0	1	719	535	19	1		1	ANXA3	4	79507428	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	7619174	79507428	111646848	17	18722											
FGG	2266	broad.mit.edu	37	chr4	155529787	155529787	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagtttttcttgaaatctaCactgccatcaagtctctaat	4	11	4	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr4:155529787C>T	uc003ioj.2	-	7	823	c.682G>A	c.(682-684)GTA>ATA	p.V228I	FGG_uc003iog.2_Missense_Mutation_p.V228I|FGG_uc003ioh.2_Missense_Mutation_p.V236I|FGG_uc010ipx.2_Missense_Mutation_p.V56I|FGG_uc010ipy.2_5'UTR|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Missense_Mutation_p.V236I	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	228	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TTGAAATCTACACTGCCATCA	0.343													T	155529787	T	T	155529787	3	4	261	1	0	0	0	0	1	0	0	0	5870	478	17	3	710	3	FGG	4	155529787	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	76022359	155529787	35624489	18	18723											
PLEKHG4B	153478	broad.mit.edu	37	chr5	181778	181778	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accgagtccccgacagcatcGtcaagggcacaggtacggtg	13	13	1	0	rs114040866	by1000genomes	TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr5:181778G>A	uc003jak.2	+	17	3534	c.3484G>A	c.(3484-3486)GTC>ATC	p.V1162I		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1162					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CGACAGCATCGTCAAGGGCAC	0.637													A	181778	A	A	181778	3	1	261	1	0	0	0	0	1	0	0	0	12072	1145	40	1	3550	1	PLEKHG4B	5	181778	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08		181778	180733482	19	18724											
BASP1	10409	broad.mit.edu	37	chr5	17275370	17275370	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagaagggctacaatgtgaaCgacgagaaagccaaggagaa	13	6	0	4			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr5:17275370C>T	uc003jfx.2	+	2	224	c.45C>T	c.(43-45)AAC>AAT	p.N15N		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	15					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						ACAATGTGAACGACGAGAAAG	0.567													T	17275370	T	T	17275370	2	4	261	1	0	0	0	0	0	0	0	1	1317	535	19	1		1	BASP1	5	17275370	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	17093592	17275370	163639890	20	18725											
CDH18	1016	broad.mit.edu	37	chr5	19721516	19721516	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatgctgtaaaccacccgagCgctgtttccataggtagggt	11	10	0	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr5:19721516C>T	uc003jgc.2	-	4	960	c.583G>A	c.(583-585)GCT>ACT	p.A195T	CDH18_uc003jgd.2_Missense_Mutation_p.A195T|CDH18_uc011cnm.1_Missense_Mutation_p.A195T	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	195	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A195T(1)		ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ACCACCCGAGCGCTGTTTCCA	0.463													T	19721516	T	T	19721516	3	4	261	1	0	0	0	0	1	0	0	0	3103	768	27	1	1825	1	CDH18	5	19721516	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	2446146	19721516	161193744	21	18726											
PIK3R1	5295	broad.mit.edu	37	chr5	67575468	67575468	+	Frame_Shift_Del	DEL	G	-	-													tggaaatgatcgatgtgcacGttttggctgacgctttcaaa					rs143572224		TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr5:67575468delG	uc003jva.2	+	5	1101	c.541delG	c.(541-543)GTTfs	p.V181fs	PIK3R1_uc003jvb.2_Frame_Shift_Del_p.V181fs	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	181	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CGATGTGCACGTTTTGGCTGA	0.393			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			-	67575468	-	-	67575468	7	5	261	1	0	1	0	1	0	0	0	0	11918	1145	40	0	555	0	PIK3R1	5	67575468	Frame_Shift_Del	DEL	G	TCGA-76-4929-01A-01D-1486-08	47853952	67575468	113339792	22	18727											
POU5F2	134187	broad.mit.edu	37	chr5	93077142	93077142	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgccggccagaccatcaccCtgccaggggccgcctgggtg	14	17	1	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr5:93077142C>T	uc003kkl.1	-	1	168	c.128G>A	c.(127-129)AGG>AAG	p.R43K	FAM172A_uc010jbd.2_Intron|FAM172A_uc011cuf.1_Intron|FAM172A_uc011cug.1_Intron|FAM172A_uc011cuh.1_Intron|FAM172A_uc011cui.1_Intron|FAM172A_uc011cuj.1_Intron	NM_153216	NP_694948	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	43						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		GACCATCACCCTGCCAGGGGC	0.687													T	93077142	T	T	93077142	3	4	261	1	0	0	0	0	1	0	0	0	12283	681	24	3	862	3	POU5F2	5	93077142	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	25501674	93077142	87838118	23	18728											
FTMT	94033	broad.mit.edu	37	chr5	121187720	121187720	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgctggcgtctctgcgccCggtgcgctgctgcttcgcgc	14	16	1	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr5:121187720C>T	uc003kss.2	+	1	71	c.62C>T	c.(61-63)CCG>CTG	p.P21L		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	21					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		TCTCTGCGCCCGGTGCGCTGC	0.736													T	121187720	T	T	121187720	3	4	261	1	0	0	0	0	1	0	0	0	6085	652	23	2	64	2	FTMT	5	121187720	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	28110578	121187720	59727540	24	18729											
SLU7	10569	broad.mit.edu	37	chr5	159842130	159842130	+	Splice_Site	DEL	A	-	-													atacaaaaaattaagtacttActttccttcttcatcaactt							TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr5:159842130delA	uc003lyg.2	-	2	325	c.170_splice	c.e2+1	p.K57_splice	SLU7_uc003lyh.1_Splice_Site_p.K57_splice|SLU7_uc003lyi.1_Splice_Site_p.K57_splice	NM_006425	NP_006416	O95391	SLU7_HUMAN	step II splicing factor SLU7						alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTAAGTACTTACTTTCCTTCT	0.358													-	159842130	-	-	159842130	8	5	261	1	0	1	0	1	0	0	1	0	14755	405	14	0	1648	0	SLU7	5	159842130	Splice_Site	DEL	A	TCGA-76-4929-01A-01D-1486-08	38654410	159842130	21073130	25	18730											
GABRB2	2561	broad.mit.edu	37	chr5	160721269	160721269	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	catgtcgttccagagcatttCggccaaaactatgcctgggc	10	12	0	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr5:160721269C>T	uc003lys.1	-	11	1576	c.1358G>A	c.(1357-1359)CGA>CAA	p.R453Q	GABRB2_uc011deh.1_Missense_Mutation_p.R254Q|GABRB2_uc003lyr.1_Missense_Mutation_p.R415Q|GABRB2_uc003lyt.1_Missense_Mutation_p.R415Q|GABRB2_uc010jiu.1_Missense_Mutation_p.R352Q	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	453	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAGAGCATTTCGGCCAAAACT	0.532													T	160721269	T	T	160721269	3	4	261	1	0	0	0	0	1	0	0	0	6167	884	31	2	184	2	GABRB2	5	160721269	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	879139	160721269	20193991	26	18731											
FKBPL	63943	broad.mit.edu	37	chr6	32097113	32097113	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtttcctccctccatggccCtacgcccatagttagctctg	7	16	1	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr6:32097113C>T	uc003nzr.2	-	2	715	c.445G>A	c.(445-447)GGG>AGG	p.G149R	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	149					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						CTCCATGGCCCTACGCCCATA	0.582													T	32097113	T	T	32097113	3	4	261	1	0	0	0	0	1	0	0	0	5916	681	24	3	608	3	FKBPL	6	32097113	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08		32097113	139017954	27	18732											
PKHD1	5314	broad.mit.edu	37	chr6	51890856	51890856	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtatctggggggctggcaggGtttcacaccagatgctcgcc	15	11	2	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr6:51890856G>T	uc003pah.1	-	32	4028	c.3752C>A	c.(3751-3753)ACC>AAC	p.T1251N	PKHD1_uc003pai.2_Missense_Mutation_p.T1251N	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1251	Extracellular (Potential).|IPT/TIG 7.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GGCTGGCAGGGTTTCACACCA	0.597													T	51890856	T	T	51890856	3	4	261	1	0	0	0	0	1	0	0	0	11971	1261	44	5	8655	5	PKHD1	6	51890856	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	19793743	51890856	119224211	28	18733											
WBSCR17	64409	broad.mit.edu	37	chr7	70597844	70597844	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgaacttgatcgcggtagCcggcttcgtgctcttcctgg	13	11	1	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr7:70597844C>T	uc003tvy.2	+	1	56	c.56C>T	c.(55-57)GCC>GTC	p.A19V		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	19	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				ATCGCGGTAGCCGGCTTCGTG	0.677													T	70597844	T	T	70597844	3	4	261	1	0	0	0	0	1	0	0	0	17261	739	26	3	58	3	WBSCR17	7	70597844	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08		70597844	88540819	29	18734											
CLIP2	7461	broad.mit.edu	37	chr7	73791076	73791076	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcaaacaggaggtcgagaGtttgcgggagaagctcctgg	18	7	0	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr7:73791076G>A	uc003uam.2	+	10	2672	c.2345G>A	c.(2344-2346)AGT>AAT	p.S782N	CLIP2_uc003uan.2_Missense_Mutation_p.S747N|CLIP2_uc003uao.2_Missense_Mutation_p.S176N	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	782	Potential.					microtubule associated complex				skin(3)	3						GAGGTCGAGAGTTTGCGGGAG	0.632													A	73791076	A	A	73791076	3	1	261	1	0	0	0	0	1	0	0	0	3533	1029	36	3	2379	3	CLIP2	7	73791076	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	3193232	73791076	85347587	30	18735											
AKAP9	10142	broad.mit.edu	37	chr7	91711915	91711915	+	Frame_Shift_Del	DEL	C	-	-													tcttagagctgaatcagtggCtaccaaagcagaacttgcca							TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr7:91711915delC	uc003ulg.2	+	32	8324	c.8099delC	c.(8098-8100)GCTfs	p.A2700fs	AKAP9_uc003ulf.2_Frame_Shift_Del_p.A2692fs|AKAP9_uc003uli.2_Frame_Shift_Del_p.A2323fs|AKAP9_uc003ulj.2_Frame_Shift_Del_p.A470fs|AKAP9_uc003ulk.2_5'Flank	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2712	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAATCAGTGGCTACCAAAGCA	0.373			T	BRAF	papillary thyroid								-	91711915	-	-	91711915	7	5	261	1	0	1	0	1	0	0	0	0	459	797	28	0	8225	0	AKAP9	7	91711915	Frame_Shift_Del	DEL	C	TCGA-76-4929-01A-01D-1486-08	17920839	91711915	67426748	31	18736											
JHDM1D	80853	broad.mit.edu	37	chr7	139824534	139824534	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaactccaagattcataaCgtgccaaattttcatctgtt	5	9	3	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr7:139824534C>T	uc003vvm.2	-	7	942	c.938G>A	c.(937-939)CGT>CAT	p.R313H		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	313	JmjC.				midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					AGATTCATAACGTGCCAAATT	0.358													T	139824534	T	T	139824534	3	4	261	1	0	0	0	0	1	0	0	0	7948	536	19	1	1943	1	JHDM1D	7	139824534	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	48112619	139824534	19314129	32	18737											
MGAM	8972	broad.mit.edu	37	chr7	141765179	141765179	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgaggggtcgtcatcacccGctccacatttccctcttctg	9	16	4	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr7:141765179G>A	uc003vwy.2	+	38	4583	c.4529G>A	c.(4528-4530)CGC>CAC	p.R1510H		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1510	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTCATCACCCGCTCCACATTT	0.597													A	141765179	A	A	141765179	3	1	261	1	0	0	0	0	1	0	0	0	9541	1087	38	1	4675	1	MGAM	7	141765179	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	1940645	141765179	17373484	33	18738											
KEL	3792	broad.mit.edu	37	chr7	142658027	142658027	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttcctcacccagtattctccGaagtcggtttttgttctttg	7	11	3	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr7:142658027G>A	uc003wcb.2	-	4	598	c.388C>T	c.(388-390)CGG>TGG	p.R130W		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	130	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					AGTATTCTCCGAAGTCGGTTT	0.502													A	142658027	A	A	142658027	3	1	261	1	0	0	0	0	1	0	0	0	8142	1057	37	2	1874	2	KEL	7	142658027	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	892848	142658027	16480636	34	18739											
NEFL	4747	broad.mit.edu	37	chr8	24813390	24813390	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatttcgtccatcaagctgtCgatgcgcttctcgagctcgg	11	12	2	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr8:24813390C>T	uc003xee.2	-	1	742	c.640G>A	c.(640-642)GAC>AAC	p.D214N		NM_006158	NP_006149	P07196	NFL_HUMAN	neurofilament, light polypeptide 68kDa	214	Rod.|Coil 1B.				anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		ATCAAGCTGTCGATGCGCTTC	0.632													T	24813390	T	T	24813390	3	4	261	1	0	0	0	0	1	0	0	0	10315	884	31	2	1008	2	NEFL	8	24813390	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08		24813390	121550632	35	18740											
INSL6	11172	broad.mit.edu	37	chr9	5185459	5185459	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaacggaactggctccagttGgcatggccgcagagtttttc	12	10	0	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr9:5185459G>A	uc003zix.2	-	1	160	c.144C>T	c.(142-144)GCC>GCT	p.A48A		NM_007179	NP_009110	Q9Y581	INSL6_HUMAN	insulin-like 6 precursor	48						extracellular region	hormone activity				0	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		GGCTCCAGTTGGCATGGCCGC	0.532													A	5185459	A	A	5185459	2	1	261	1	0	0	0	0	0	0	0	1	7770	1335	47	3		3	INSL6	9	5185459	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08		5185459	136027972	36	18741											
NUDT2	318	broad.mit.edu	37	chr9	34343182	34343182	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagggagacccaagaggaagCaggcatagaagcaggccagc	16	9	0	3			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr9:34343182C>T	uc003zub.2	+	5	546	c.188C>T	c.(187-189)GCA>GTA	p.A63V	NUDT2_uc003zuc.2_Missense_Mutation_p.A63V|NUDT2_uc003zud.2_Missense_Mutation_p.A63V	NM_001161	NP_001152	P50583	AP4A_HUMAN	nudix-type motif 2	63	Nudix box.|Nudix hydrolase.				induction of apoptosis|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity|GTP binding				0			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CAAGAGGAAGCAGGCATAGAA	0.493													T	34343182	T	T	34343182	3	4	261	1	0	0	0	0	1	0	0	0	10737	710	25	3	194	3	NUDT2	9	34343182	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	29157723	34343182	106870249	37	18742											
NAA35	60560	broad.mit.edu	37	chr9	88633637	88633637	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atgtctgacctcaataaataTagccctcctcctcagtctcc	4	15	4	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr9:88633637T>C	uc004aoi.3	+	21	2075	c.1938T>C	c.(1936-1938)TAT>TAC	p.Y646Y	NAA35_uc004aoj.3_Silent_p.Y646Y	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	646					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						TCAATAAATATAGCCCTCCTC	0.363													C	88633637	C	C	88633637	2	2	261	1	0	0	0	0	0	0	0	1	10123	1413	49	4		4	NAA35	9	88633637	Silent	SNP	T	TCGA-76-4929-01A-01D-1486-08	54290455	88633637	52579794	38	18743											
PTPN3	5774	broad.mit.edu	37	chr9	112189356	112189356	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tccacaagtttttgcaagatCggtaattcagcatgttgaag	9	7	1	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr9:112189356C>T	uc004bed.2	-	12	987	c.875G>A	c.(874-876)CGA>CAA	p.R292Q	PTPN3_uc004beb.2_Missense_Mutation_p.R161Q|PTPN3_uc004bec.2_Missense_Mutation_p.R161Q|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.R292Q|PTPN3_uc011lwh.1_Missense_Mutation_p.R183Q|PTPN3_uc011lwe.1_Missense_Mutation_p.R5Q|PTPN3_uc011lwf.1_Missense_Mutation_p.R5Q	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	292	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						TTTGCAAGATCGGTAATTCAG	0.448													T	112189356	T	T	112189356	3	4	261	1	0	0	0	0	1	0	0	0	12789	884	31	2	1926	2	PTPN3	9	112189356	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	23555719	112189356	29024075	39	18744											
RGS3	5998	broad.mit.edu	37	chr9	116268773	116268773	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagctggcccacgagatccGgtgacaggggacagcgggtg	19	10	0	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr9:116268773G>A	uc004bhq.2	+	13	1294	c.1085G>A	c.(1084-1086)CGG>CAG	p.R362Q	RGS3_uc004bhr.2_Missense_Mutation_p.R250Q|RGS3_uc004bhs.2_Missense_Mutation_p.R252Q|RGS3_uc004bht.2_Missense_Mutation_p.R81Q|RGS3_uc010muy.2_Missense_Mutation_p.R81Q|RGS3_uc004bhu.2_5'UTR	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	362	PDZ.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						CACGAGATCCGGTGACAGGGG	0.677													A	116268773	A	A	116268773	3	1	261	1	0	0	0	0	1	0	0	0	13306	1130	39	2	1272	2	RGS3	9	116268773	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	4079417	116268773	24944658	40	18745											
NEBL	10529	broad.mit.edu	37	chr10	21112168	21112168	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcttctggttttctttaactCtctttagttctggaggatca	7	8	6	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr10:21112168C>T	uc001iqi.2	-	19	2328	c.1931G>A	c.(1930-1932)AGA>AAA	p.R644K	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	644	Nebulin 18.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TTCTTTAACTCTCTTTAGTTC	0.284													T	21112168	T	T	21112168	3	4	261	1	0	0	0	0	1	0	0	0	10303	913	32	3	1153	3	NEBL	10	21112168	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08		21112168	114422579	41	18746											
RBP3	5949	broad.mit.edu	37	chr10	48390589	48390589	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgggacttgtgggggaggctCgggggtgctgggctcatagg	22	6	1	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr10:48390589C>T	uc001jez.2	-	1	403	c.289G>A	c.(289-291)GAG>AAG	p.E97K		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	97	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GGGGGAGGCTCGGGGGTGCTG	0.627													T	48390589	T	T	48390589	3	4	261	1	0	0	0	0	1	0	0	0	13157	893	31	2	3470	2	RBP3	10	48390589	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	27278421	48390589	87144158	42	18747											
ADO	84890	broad.mit.edu	37	chr10	64564912	64564912	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggggcggccgcggcgcttcCgatcgcgacgcggcttctgg	19	14	1	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr10:64564912C>T	uc001jmg.2	+	1	397	c.93C>T	c.(91-93)TCC>TCT	p.S31S		NM_032804	NP_116193	Q96SZ5	AEDO_HUMAN	2-aminoethanethiol (cysteamine) dioxygenase	31							cysteamine dioxygenase activity|metal ion binding				0	Prostate(12;0.0297)|all_hematologic(501;0.228)					GCGGCGCTTCCGATCGCGACG	0.711													T	64564912	T	T	64564912	2	4	261	1	0	0	0	0	0	0	0	1	325	639	23	2		2	ADO	10	64564912	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	16174323	64564912	70969835	43	18748											
NT5C2	22978	broad.mit.edu	37	chr10	104934623	104934623	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaaatacttaccgatgataGgcttctcgacgatacttttt	6	9	1	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr10:104934623G>A	uc001kwo.2	-	3	279	c.93C>T	c.(91-93)GCC>GCT	p.A31A	NT5C2_uc001kwq.2_Silent_p.A31A|NT5C2_uc001kwp.2_Intron	NM_012229	NP_036361	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II	31					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding				0		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)	ACCGATGATAGGCTTCTCGAC	0.254													A	104934623	A	A	104934623	2	1	261	1	0	0	0	0	0	0	0	1	10687	987	35	3		3	NT5C2	10	104934623	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08	40369711	104934623	30600124	44	18749											
SLC22A25	387601	broad.mit.edu	37	chr11	62931319	62931319	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tagcacagagctcctctgagGggcagctaggctatttactc	11	11	1	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr11:62931319G>C	uc001nwr.1	-	9	1621	c.1621C>G	c.(1621-1623)CCT>GCT	p.P541A	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	541	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						CTCCTCTGAGGGGCAGCTAGG	0.507													C	62931319	C	C	62931319	3	2	261	1	0	0	0	0	1	0	0	0	14454	1232	43	5	26	5	SLC22A25	11	62931319	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08		62931319	72075197	45	18750											
LRRC32	2615	broad.mit.edu	37	chr11	76371933	76371933	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagcctggggctgggaggccGtctgaaaggcctcgatgctg	17	11	1	1	rs147861179		TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr11:76371933G>A	uc001oxq.3	-	3	947	c.704C>T	c.(703-705)ACG>ATG	p.T235M	LRRC32_uc001oxr.3_Missense_Mutation_p.T235M|LRRC32_uc010rsf.1_Missense_Mutation_p.T235M	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	235	LRR 8.|Extracellular (Potential).					integral to plasma membrane					0						CTGGGAGGCCGTCTGAAAGGC	0.617													A	76371933	A	A	76371933	3	1	261	1	0	0	0	0	1	0	0	0	8987	1145	40	1	1288	1	LRRC32	11	76371933	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	13440614	76371933	58634583	46	18751											
PIK3C2G	5288	broad.mit.edu	37	chr12	18544153	18544153	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aaaggagtgtataaaacataTtgccagactttcacagaaac	7	7	1	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr12:18544153T>C	uc001rdt.2	+	14	2086	c.1970T>C	c.(1969-1971)ATT>ACT	p.I657T	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.I698T|PIK3C2G_uc010sic.1_Missense_Mutation_p.I476T	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	657					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				ATAAAACATATTGCCAGACTT	0.383													C	18544153	C	C	18544153	3	2	261	1	0	0	0	0	1	0	0	0	11911	1493	52	4	2020	4	PIK3C2G	12	18544153	Missense_Mutation	SNP	T	TCGA-76-4929-01A-01D-1486-08		18544153	115307742	47	18752											
KSR2	283455	broad.mit.edu	37	chr12	117962680	117962680	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgatgatggccaggtgaggCgggctcatgcaggcacccat	16	10	1	3	rs140960062	by1000genomes	TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr12:117962680C>T	uc001two.2	-	14	2164	c.2109G>A	c.(2107-2109)CCG>CCA	p.P703P		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	732	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCAGGTGAGGCGGGCTCATGC	0.473													T	117962680	T	T	117962680	2	4	261	1	0	0	0	0	0	0	0	1	8582	755	27	1		1	KSR2	12	117962680	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	99418527	117962680	15889215	48	18753											
TMEM132D	121256	broad.mit.edu	37	chr12	130184667	130184667	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccacgggggtcccctccGgctggtccacggacttcctc	12	18	0	0	rs146143180		TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr12:130184667G>A	uc009zyl.1	-	2	984	c.656C>T	c.(655-657)CCG>CTG	p.P219L		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	219	Extracellular (Potential).					integral to membrane		p.P219L(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGTCCCCTCCGGCTGGTCCAC	0.682													A	130184667	A	A	130184667	3	1	261	1	0	0	0	0	1	0	0	0	16044	1116	39	2	2675	2	TMEM132D	12	130184667	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	12221987	130184667	3667228	49	18754											
SFRS8	6433	broad.mit.edu	37	chr12	132249171	132249171	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	acccagcagttgccccacccTgtgtagttgttgaggagaag	12	11	0	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr12:132249171T>A	uc001uja.1	+	12	2031	c.1891T>A	c.(1891-1893)TGT>AGT	p.C631S	SFRS8_uc010tbn.1_Missense_Mutation_p.C631S|SFRS8_uc001ujb.1_Missense_Mutation_p.C424S	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	631					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		TGCCCCACCCTGTGTAGTTGT	0.423													A	132249171	A	A	132249171	3	1	261	1	0	0	0	0	1	0	0	0	14183	1580	55	5	1937	5	SFRS8	12	132249171	Missense_Mutation	SNP	T	TCGA-76-4929-01A-01D-1486-08	2064504	132249171	1602724	50	18755											
LRFN5	145581	broad.mit.edu	37	chr14	42356720	42356720	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtcatacacatgagatgagaGtcctggagggacaaagggca	14	7	1	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr14:42356720G>T	uc001wvm.2	+	3	2090	c.892G>T	c.(892-894)GTC>TTC	p.V298F	LRFN5_uc010ana.2_Missense_Mutation_p.V298F	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	298	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGAGATGAGAGTCCTGGAGGG	0.478										HNSCC(30;0.082)			T	42356720	T	T	42356720	3	4	261	1	0	0	0	0	1	0	0	0	8941	1029	36	5	894	5	LRFN5	14	42356720	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08		42356720	64992820	51	18756											
MOAP1	64112	broad.mit.edu	37	chr14	93650454	93650454	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagtctgtactcccccaagGgagctaaaccagcctgcaga	10	14	1	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr14:93650454G>A	uc001ybj.2	-	3	504	c.134C>T	c.(133-135)CCC>CTC	p.P45L	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	45					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		ctcccccaagggagctaaacc	0													A	93650454	A	A	93650454	3	1	261	1	0	0	0	0	1	0	0	0	9680	1232	43	3	925	3	MOAP1	14	93650454	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	51293734	93650454	13699086	52	18757											
RBBP6	5930	broad.mit.edu	37	chr16	24581488	24581489	+	Frame_Shift_Del	DEL	TT	-	-													gaaaaaggcgtagataaagaTtttgagtcttcttcaatgaa							TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr16:24581488_24581489delTT	uc002dmh.2	+	17	4517_4518	c.3477_3478delTT	c.(3475-3480)GATTTTfs	p.D1159fs	RBBP6_uc010vcb.1_Frame_Shift_Del_p.D1026fs|RBBP6_uc002dmi.2_Frame_Shift_Del_p.D1125fs|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Frame_Shift_Del_p.D992fs	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1159_1160					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TAGATAAAGATTTTGAGTCTTC	0.342													-	24581489	-	-	24581488	7	5	261	1	0	1	0	1	0	0	0	0	13103	1490	52	0	3597	0	RBBP6	16	24581488	Frame_Shift_Del	DEL	TT	TCGA-76-4929-01A-01D-1486-08		24581488	65773265	53	18758											
IRX5	10265	broad.mit.edu	37	chr16	54967470	54967470	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcagccgggcgtcgccggcCccggcgccgtcacgctcgcc	16	20	1	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr16:54967470C>T	uc002ehv.2	+	3	1137	c.1137C>T	c.(1135-1137)GCC>GCT	p.A379A	IRX5_uc002ehw.2_Silent_p.A313A	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	379					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						CGTCGCCGGCCCCGGCGCCGT	0.721													T	54967470	T	T	54967470	2	4	261	1	0	0	0	0	0	0	0	1	7847	610	22	3		3	IRX5	16	54967470	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	30385982	54967470	35387283	54	18759											
CLEC3A	10143	broad.mit.edu	37	chr16	78064624	78064624	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggaccgtgcacagcctaaCggtggcaagcgagaaaactg	14	10	0	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr16:78064624C>T	uc002ffh.3	+	3	561	c.480C>T	c.(478-480)AAC>AAT	p.N160N		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	160	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						CACAGCCTAACGGTGGCAAGC	0.522													T	78064624	T	T	78064624	2	4	261	1	0	0	0	0	0	0	0	1	3510	535	19	1		1	CLEC3A	16	78064624	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	23097154	78064624	12290129	55	18760											
ACAP1	9744	broad.mit.edu	37	chr17	7253543	7253543	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ccatggaaacagccaacgctGacatcgtcaccctgtaagaa	8	13	1	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr17:7253543G>A	uc002ggd.2	+	20	2265	c.2059G>A	c.(2059-2061)GAC>AAC	p.D687N	KCTD11_uc002gge.3_5'Flank	NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	687	Required for interaction with GULP1.|ANK 3.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						AGCCAACGCTGACATCGTCAC	0.682													A	7253543	A	A	7253543	3	1	261	1	0	0	0	0	1	0	0	0	118	1290	45	3	2137	3	ACAP1	17	7253543	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08		7253543	73941667	56	18761											
TP53	7157	broad.mit.edu	37	chr17	7574003	7574003	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaggcctcattcagctctcGgaacatctcgaagcgctcac	8	15	5	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr17:7574003G>A	uc002gim.2	-	10	1218	c.1024C>T	c.(1024-1026)CGA>TGA	p.R342*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.R210*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.R342*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	342	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Nuclear export signal.|Interaction with HIPK2.		R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R342*(49)|p.0?(7)|p.R342fs*3(5)|p.R342P(3)|p.R342Q(2)|p.?(1)|p.R342_N345delRELN(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCAGCTCTCGGAACATCTCG	0.498		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7574003	A	A	7574003	4	1	261	1	0	0	0	0	0	1	0	0	16378	1124	39	2	165	2	TP53	17	7574003	Nonsense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	320460	7574003	73621207	57	18762											
TP53	7157	broad.mit.edu	37	chr17	7578476	7578476	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggacgcgggtgccgggcgGgggtgtggaatcaacccaca	19	11	1	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr17:7578476G>A	uc002gim.2	-	5	648	c.454C>T	c.(454-456)CCG>TCG	p.P152S	TP53_uc002gig.1_Missense_Mutation_p.P152S|TP53_uc002gih.2_Missense_Mutation_p.P152S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P20S|TP53_uc010cng.1_Missense_Mutation_p.P20S|TP53_uc002gii.1_Missense_Mutation_p.P20S|TP53_uc010cnh.1_Missense_Mutation_p.P152S|TP53_uc010cni.1_Missense_Mutation_p.P152S|TP53_uc002gij.2_Missense_Mutation_p.P152S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P59S|TP53_uc002gio.2_Missense_Mutation_p.P20S|TP53_uc010vug.1_Missense_Mutation_p.P113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	152	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(57)|p.P152S(21)|p.P152fs*18(17)|p.P152T(7)|p.0?(7)|p.P152fs*29(5)|p.P152P(5)|p.P152Q(4)|p.P152fs*14(4)|p.P152fs*28(3)|p.P152R(3)|p.T150fs*16(3)|p.P152A(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.P152_P153del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152_P153insXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGCCGGGCGGGGGTGTGGAA	0.607		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578476	A	A	7578476	3	1	261	1	0	0	0	0	1	0	0	0	16378	1232	43	3	844	3	TP53	17	7578476	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	4473	7578476	73616734	58	18763											
PFAS	5198	broad.mit.edu	37	chr17	8170745	8170745	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagggcagtaatggagaccgGgagatggccgatgccttcca	16	9	0	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr17:8170745G>A	uc002gkr.2	+	25	3372	c.3231G>A	c.(3229-3231)CGG>CGA	p.R1077R	PFAS_uc010vuv.1_Silent_p.R653R|PFAS_uc002gks.2_Silent_p.R156R	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	1077	Glutamine amidotransferase type-1.				'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	ATGGAGACCGGGAGATGGCCG	0.612													A	8170745	A	A	8170745	2	1	261	1	0	0	0	0	0	0	0	1	11754	1219	43	3		3	PFAS	17	8170745	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08	592269	8170745	73024465	59	18764											
KRT13	3860	broad.mit.edu	37	chr17	39661389	39661389	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctctgcttcaggtgccaGtcacggatcttcacctccag	11	14	5	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr17:39661389G>A	uc002hwu.1	-	1	477	c.414C>T	c.(412-414)GAC>GAT	p.D138D	KRT13_uc002hwv.1_Silent_p.D138D|KRT13_uc002hww.2_Silent_p.D31D|KRT13_uc010wfr.1_Silent_p.D31D|KRT13_uc010cxo.2_Silent_p.D138D|KRT13_uc002hwx.1_Silent_p.D126D	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	138	Coil 1A.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				TCAGGTGCCAGTCACGGATCT	0.602													A	39661389	A	A	39661389	2	1	261	1	0	0	0	0	0	0	0	1	8450	1020	36	3		3	KRT13	17	39661389	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08	31490644	39661389	41533821	60	18765											
FMNL1	752	broad.mit.edu	37	chr17	43320637	43320637	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaagaacttggccatcacCctgcggaagggcaacctggg	13	13	1	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr17:43320637C>T	uc002iin.2	+	17	2363	c.2163C>T	c.(2161-2163)ACC>ACT	p.T721T	FMNL1_uc002iiq.2_Silent_p.T299T|FMNL1_uc010dag.2_RNA	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	721	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						TGGCCATCACCCTGCGGAAGG	0.642													T	43320637	T	T	43320637	2	4	261	1	0	0	0	0	0	0	0	1	5951	610	22	3		3	FMNL1	17	43320637	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	3659248	43320637	37874573	61	18766											
RGS9	8787	broad.mit.edu	37	chr17	63193312	63193312	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcgaattgatccgagaccCcaaaggtcgacagagcttcc	10	13	0	3			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr17:63193312C>T	uc002jfe.2	+	13	1039	c.929C>T	c.(928-930)CCC>CTC	p.P310L	RGS9_uc010dem.2_Missense_Mutation_p.P307L|RGS9_uc002jfd.2_Missense_Mutation_p.P307L|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.P81L	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	310	RGS.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						ATCCGAGACCCCAAAGGTCGA	0.423													T	63193312	T	T	63193312	3	4	261	1	0	0	0	0	1	0	0	0	13313	623	22	3	979	3	RGS9	17	63193312	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	19872675	63193312	18001898	62	18767											
ICAM5	7087	broad.mit.edu	37	chr19	10405102	10405102	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccggagatggatgaatctacCtgcccaagtcaccagacgtg	11	12	2	3			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr19:10405102C>A	uc002mnu.3	+	9	2081	c.2016C>A	c.(2014-2016)ACC>ACA	p.T672T	ICAM5_uc002mnv.3_Silent_p.T547T	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	672	Extracellular (Potential).|Ig-like C2-type 8.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			ATGAATCTACCTGCCCAAGTC	0.692													A	10405102	A	A	10405102	2	1	261	1	0	0	0	0	0	0	0	1	7483	668	24	5		5	ICAM5	19	10405102	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08		10405102	48723881	63	18768											
NANP	140838	broad.mit.edu	37	chr20	25597030	25597030	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aaaggaaataacattcttcaGccaattttctattggctgca	6	8	3	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr20:25597030G>C	uc002wuy.2	-	2	342	c.278C>G	c.(277-279)GCT>GGT	p.A93G		NM_152667	NP_689880	Q8TBE9	NANP_HUMAN	N-acetylneuraminic acid phosphatase	93					N-acetylneuraminate biosynthetic process		N-acylneuraminate-9-phosphatase activity|phosphoglycolate phosphatase activity				0						ACATTCTTCAGCCAATTTTCT	0.403													C	25597030	C	C	25597030	3	2	261	1	0	0	0	0	1	0	0	0	10154	971	34	5	472	5	NANP	20	25597030	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08		25597030	37428490	64	18769											
CDH4	1002	broad.mit.edu	37	chr20	60509217	60509217	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggccggtgggcgctgagcCccagtacccgatcaggccca	15	16	1	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr20:60509217C>T	uc002ybn.1	+	15	2497	c.2483C>T	c.(2482-2484)CCC>CTC	p.P828L	CDH4_uc002ybp.1_Missense_Mutation_p.P754L	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	828	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGCGCTGAGCCCCAGTACCCG	0.677													T	60509217	T	T	60509217	3	4	261	1	0	0	0	0	1	0	0	0	3112	623	22	3	2541	3	CDH4	20	60509217	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	34912187	60509217	2516303	65	18770											
NTSR1	4923	broad.mit.edu	37	chr20	61341151	61341151	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccatctggctcgcctcggccCtgctggcggtgcctatgctg	13	16	1	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr20:61341151C>A	uc002ydf.2	+	1	963	c.592C>A	c.(592-594)CTG>ATG	p.L198M		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	198	Helical; Name=4; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CGCCTCGGCCCTGCTGGCGGT	0.672													A	61341151	A	A	61341151	3	1	261	1	0	0	0	0	1	0	0	0	10710	680	24	5	594	5	NTSR1	20	61341151	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	831934	61341151	1684369	66	18771											
GAB4	128954	broad.mit.edu	37	chr22	17450832	17450832	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgccttgaaggggtacacaCcctcattatccgcctcagag	10	13	2	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr22:17450832C>T	uc002zlw.2	-	4	1045	c.937_splice	c.e4+1	p.A313_splice	GAB4_uc010gqs.1_Intron	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member											large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GGGGTACACACCCTCATTATC	0.597													T	17450832	T	T	17450832	5	4	261	1	0	0	0	0	0	0	1	0	6151	521	18	3	814	3	GAB4	22	17450832	Splice_Site	SNP	C	TCGA-76-4929-01A-01D-1486-08		17450832	33853734	67	18772											
DEPDC5	9681	broad.mit.edu	37	chr22	32234828	32234828	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagtagcccactctatagcCgaggtgagtttttctccttg	10	11	2	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chr22:32234828C>T	uc003als.2	+	27	2627	c.2485C>T	c.(2485-2487)CGA>TGA	p.R829*	DEPDC5_uc011als.1_Nonsense_Mutation_p.R760*|DEPDC5_uc011alu.1_Nonsense_Mutation_p.R838*|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Nonsense_Mutation_p.R829*|DEPDC5_uc003alu.2_Nonsense_Mutation_p.R278*|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Nonsense_Mutation_p.R159*|DEPDC5_uc003alw.2_Nonsense_Mutation_p.R127*|DEPDC5_uc011alx.1_Intron	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	829					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						ACTCTATAGCCGAGGTGAGTT	0.458													T	32234828	T	T	32234828	4	4	261	1	0	0	0	0	0	1	0	0	4442	644	23	2	2605	2	DEPDC5	22	32234828	Nonsense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	14783996	32234828	19069738	68	18773											
GYG2	8908	broad.mit.edu	37	chrX	2799206	2799206	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtatcgactacatggggaaGgacgcgtttgctcgcatcca	12	11	0	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chrX:2799206G>A	uc004cqs.1	+	12	1740	c.1458G>A	c.(1456-1458)AAG>AAA	p.K486K	GYG2_uc004cqt.1_Silent_p.K455K|GYG2_uc004cqu.1_Silent_p.K454K|GYG2_uc004cqv.1_Silent_p.K229K|GYG2_uc004cqw.1_Silent_p.K446K|GYG2_uc004cqx.1_Silent_p.K384K|GYG2_uc010ndc.1_Silent_p.K264K	NM_003918	NP_003909	O15488	GLYG2_HUMAN	glycogenin 2 isoform b	486					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			ovary(1)|kidney(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACATGGGGAAGGACGCGTTTG	0.552													A	2799206	A	A	2799206	2	1	261	1	0	0	0	0	0	0	0	1	6906	991	35	3		3	GYG2	23	2799206	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08		2799206	152471354	69	18774											
MXRA5	25878	broad.mit.edu	37	chrX	3229254	3229254	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	actctcatctcgtccttcccGacctgattttcagcaaagca	5	15	3	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chrX:3229254G>A	uc004crg.3	-	7	7147	c.6990C>T	c.(6988-6990)GTC>GTT	p.V2330V		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2330	Ig-like C2-type 7.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CGTCCTTCCCGACCTGATTTT	0.542													A	3229254	A	A	3229254	2	1	261	1	0	0	0	0	0	0	0	1	10003	1045	37	2		2	MXRA5	23	3229254	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08	430048	3229254	152041306	70	18775											
ARHGAP6	395	broad.mit.edu	37	chrX	11272748	11272748	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcctgcagccgggccctcTccagctctgagagactctgg	11	16	3	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chrX:11272748T>C	uc004cup.1	-	2	1541	c.668A>G	c.(667-669)GAG>GGG	p.E223G	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.E223G|ARHGAP6_uc004cum.1_Missense_Mutation_p.E20G|ARHGAP6_uc004cun.1_Missense_Mutation_p.E43G|ARHGAP6_uc010neb.1_Missense_Mutation_p.E45G|ARHGAP6_uc011mif.1_Missense_Mutation_p.E20G	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	223					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CCGGGCCCTCTCCAGCTCTGA	0.522													C	11272748	C	C	11272748	3	2	261	1	0	0	0	0	1	0	0	0	887	1551	54	4	2426	4	ARHGAP6	23	11272748	Missense_Mutation	SNP	T	TCGA-76-4929-01A-01D-1486-08	8043494	11272748	143997812	71	18776											
CDKL5	6792	broad.mit.edu	37	chrX	18627018	18627018	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacctcttccttccatacaCgccagaagtctgaggtatgt	8	13	2	2			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chrX:18627018C>T	uc004cym.2	+	13	2285	c.2032C>T	c.(2032-2034)CGC>TGC	p.R678C	CDKL5_uc004cyn.2_Missense_Mutation_p.R678C	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	678					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CTTCCATACACGCCAGAAGTC	0.433													T	18627018	T	T	18627018	3	4	261	1	0	0	0	0	1	0	0	0	3157	536	19	1	2078	1	CDKL5	23	18627018	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	7354270	18627018	136643542	72	18777											
IL1RAPL1	11141	broad.mit.edu	37	chrX	29972739	29972739	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgttttgcccttgaaatcctAcctgatatgcttgaaaagca	7	10	0	3			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chrX:29972739A>G	uc004dby.2	+	10	1810	c.1302A>G	c.(1300-1302)CTA>CTG	p.L434L		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	434	Cytoplasmic (Potential).|TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TTGAAATCCTACCTGATATGC	0.363													G	29972739	G	G	29972739	2	3	261	1	0	0	0	0	0	0	0	1	7661	378	14	4		4	IL1RAPL1	23	29972739	Silent	SNP	A	TCGA-76-4929-01A-01D-1486-08	11345721	29972739	125297821	73	18778											
GRIPAP1	56850	broad.mit.edu	37	chrX	48831638	48831638	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcttgttcatctcccgaaGgttctcgtcgcctggcttca	8	14	5	0			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chrX:48831638G>A	uc004dly.1	-	25	2397	c.2362C>T	c.(2362-2364)CTT>TTT	p.L788F		NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1	788	Potential.					early endosome				breast(2)|kidney(1)	3						ATCTCCCGAAGGTTCTCGTCG	0.592													A	48831638	A	A	48831638	3	1	261	1	0	0	0	0	1	0	0	0	6789	1000	35	3	171	3	GRIPAP1	23	48831638	Missense_Mutation	SNP	G	TCGA-76-4929-01A-01D-1486-08	18858899	48831638	106438922	74	18779											
NOX1	27035	broad.mit.edu	37	chrX	100117739	100117739	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggagagaatggaggcaagGgagccatctgtggcctgtcg	17	8	1	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chrX:100117739G>A	uc004egj.2	-	5	614	c.408C>T	c.(406-408)TCC>TCT	p.S136S	uc010nnf.2_Intron|NOX1_uc004egl.3_Silent_p.S136S|NOX1_uc010nne.2_Silent_p.S99S	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	136	Extracellular (Potential).|Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						TGGAGGCAAGGGAGCCATCTG	0.453													A	100117739	A	A	100117739	2	1	261	1	0	0	0	0	0	0	0	1	10556	1219	43	3		3	NOX1	23	100117739	Silent	SNP	G	TCGA-76-4929-01A-01D-1486-08	51286101	100117739	55152821	75	18780											
BHLHB9	80823	broad.mit.edu	37	chrX	102004877	102004877	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtccttgcaaaatggaatgCtatatggattctgaggaatt	10	5	1	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chrX:102004877C>T	uc010nog.2	+	4	1525	c.954C>T	c.(952-954)TGC>TGT	p.C318C	BHLHB9_uc011mrq.1_Silent_p.C318C|BHLHB9_uc011mrr.1_Silent_p.C318C|BHLHB9_uc011mrs.1_Silent_p.C318C|BHLHB9_uc011mrt.1_Silent_p.C318C|BHLHB9_uc004ejo.2_Silent_p.C318C|BHLHB9_uc011mru.1_Silent_p.C318C|BHLHB9_uc011mrv.1_Silent_p.C318C	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	318						cytoplasm|nucleus	binding			ovary(2)	2						AAATGGAATGCTATATGGATT	0.398													T	102004877	T	T	102004877	2	4	261	1	0	0	0	0	0	0	0	1	1420	805	28	3		3	BHLHB9	23	102004877	Silent	SNP	C	TCGA-76-4929-01A-01D-1486-08	1887138	102004877	53265683	76	18781											
MAGEA4	4103	broad.mit.edu	37	chrX	151093031	151093031	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcagggtcaatgcaagagttCgcattgcctacccatccctg	9	13	2	1			TCGA-76-4929-01A-01D-1486-08	TCGA-76-4929-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	af4f8b89-837a-48b7-b0e7-12aec23fc285	3e0712a1-b66a-42e7-94a3-07edee7dce2b	g.chrX:151093031C>T	uc004fez.2	+	3	1051	c.895C>T	c.(895-897)CGC>TGC	p.R299C	MAGEA4_uc004ffa.2_Missense_Mutation_p.R299C|MAGEA4_uc004ffb.2_Missense_Mutation_p.R299C|MAGEA4_uc004ffc.2_Missense_Mutation_p.R299C|MAGEA4_uc004ffd.2_Missense_Mutation_p.R299C	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	299	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGCAAGAGTTCGCATTGCCTA	0.567													T	151093031	T	T	151093031	3	4	261	1	0	0	0	0	1	0	0	0	9168	884	31	2	897	2	MAGEA4	23	151093031	Missense_Mutation	SNP	C	TCGA-76-4929-01A-01D-1486-08	49088154	151093031	4177529	77	18782											
KIF1B	23095	broad.mit.edu	37	chr1	10425617	10425617	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	agatctcaaccactacctttGaaagcgccatcacacctagc	5	15	2	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr1:10425617G>C	uc001aqx.3	+	43	4865	c.4663G>C	c.(4663-4665)GAA>CAA	p.E1555Q	KIF1B_uc001aqw.3_Missense_Mutation_p.E1509Q|KIF1B_uc001aqy.2_Missense_Mutation_p.E1529Q|KIF1B_uc001aqz.2_Missense_Mutation_p.E1555Q|KIF1B_uc001ara.2_Missense_Mutation_p.E1515Q|KIF1B_uc001arb.2_Missense_Mutation_p.E1541Q	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	1555					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CACTACCTTTGAAAGCGCCAT	0.552													C	10425617	C	C	10425617	3	2	262	1	0	0	0	0	1	0	0	0	8284	1291	45	5	6172	5	KIF1B	1	10425617	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08		10425617	238825004	1	18783											
CLCNKB	1188	broad.mit.edu	37	chr1	16374889	16374889	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcctacctgggccgtgtgCgcaccacgaccatcggggag	14	15	0	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr1:16374889C>T	uc001axw.3	+	6	630	c.550C>T	c.(550-552)CGC>TGC	p.R184C	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.R184C|CLCNKB_uc001axy.3_5'Flank	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	184					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCCGTGTGCGCACCACGAC	0.662													T	16374889	T	T	16374889	3	4	262	1	0	0	0	0	1	0	0	0	3470	768	27	1	568	1	CLCNKB	1	16374889	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	5949272	16374889	232875732	2	18784											
CTH	1491	broad.mit.edu	37	chr1	70881655	70881655	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcagggttttgaatatagccGttctggaaatcccactagga	10	8	2	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr1:70881655G>T	uc001dfd.2	+	2	329	c.185G>T	c.(184-186)CGT>CTT	p.R62L	CTH_uc009wbl.1_RNA|CTH_uc001dfe.2_Missense_Mutation_p.R62L|CTH_uc010oqq.1_Missense_Mutation_p.R62L	NM_001902	NP_001893	P32929	CGL_HUMAN	cystathionase isoform 1	62		Substrate.			cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			lung(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GAATATAGCCGTTCTGGAAAT	0.378													T	70881655	T	T	70881655	3	4	262	1	0	0	0	0	1	0	0	0	4009	1145	40	5	191	5	CTH	1	70881655	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	54506766	70881655	178368966	3	18785											
SPRR2B	6701	broad.mit.edu	37	chr1	153043127	153043127	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcggtggatactttggctgGcagggtggggaaggtgtcac	18	6	1	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr1:153043127G>A	uc001fbg.2	-	2	252	c.189C>T	c.(187-189)TGC>TGT	p.C63C	SPRR2D_uc009wnz.2_Intron|SPRR2A_uc001fbf.2_Intron|SPRR2A_uc009woa.2_Intron	NM_001017418	NP_001017418	P35325	SPR2B_HUMAN	small proline-rich protein 2B	63					keratinization	cornified envelope|cytoplasm					0	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACTTTGGCTGGCAGGGTGGGG	0.557													A	153043127	A	A	153043127	2	1	262	1	0	0	0	0	0	0	0	1	15097	1195	42	3		3	SPRR2B	1	153043127	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08	82161472	153043127	96207494	4	18786											
CHRNB2	1141	broad.mit.edu	37	chr1	154542048	154542048	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctctgagctggtgacagtaCagcttatggtgtcactggcc	13	10	2	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr1:154542048C>T	uc001ffg.2	+	2	439	c.175C>T	c.(175-177)CAG>TAG	p.Q59*		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	59	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	GGTGACAGTACAGCTTATGGT	0.557													T	154542048	T	T	154542048	4	4	262	1	0	0	0	0	0	1	0	0	3391	479	17	3	181	3	CHRNB2	1	154542048	Nonsense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	1498921	154542048	94708573	5	18787											
OBSCN	84033	broad.mit.edu	37	chr1	228564849	228564849	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caccccaaggacaagacagcAgtgctgcgcgaatacgaggc	12	13	0	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr1:228564849A>G	uc009xez.1	+	101	23180	c.23136A>G	c.(23134-23136)GCA>GCG	p.A7712A	OBSCN_uc001hsr.1_Silent_p.A2341A	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	7712	Protein kinase 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACAAGACAGCAGTGCTGCGCG	0.692													G	228564849	G	G	228564849	2	3	262	1	0	0	0	0	0	0	0	1	10812	175	7	4		4	OBSCN	1	228564849	Silent	SNP	A	TCGA-76-4931-01A-01D-1486-08	74022801	228564849	20685772	6	18788											
ZP4	57829	broad.mit.edu	37	chr1	238050695	238050695	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtcttgtggtgccacaggaAgtaaatggaaactggaacag	13	6	1	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr1:238050695A>G	uc001hym.2	-	5	720	c.720T>C	c.(718-720)ACT>ACC	p.T240T	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	240	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TGCCACAGGAAGTAAATGGAA	0.502													G	238050695	G	G	238050695	2	3	262	1	0	0	0	0	0	0	0	1	18215	59	3	4		4	ZP4	1	238050695	Silent	SNP	A	TCGA-76-4931-01A-01D-1486-08	9485846	238050695	11199926	7	18789											
C1orf150	148823	broad.mit.edu	37	chr1	247712494	247712494	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaccgagtcactgtgaaaagAtgggaaattatctcctgcga	10	8	2	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr1:247712494A>G	uc001idf.2	+	1	46	c.1A>G	c.(1-3)ATG>GTG	p.M1V	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_RNA|C1orf150_uc001idb.3_RNA|C1orf150_uc009xgx.2_Intron	NM_145278	NP_660321	Q5JQS6	CA150_HUMAN	hypothetical protein LOC148823	1											0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CTGTGAAAAGATGGGAAATTA	0.488													G	247712494	G	G	247712494	3	3	262	1	0	0	0	0	1	0	0	0	2004	333	12	4	3	4	C1orf150	1	247712494	Missense_Mutation	SNP	A	TCGA-76-4931-01A-01D-1486-08	9661799	247712494	1538127	8	18790											
XDH	7498	broad.mit.edu	37	chr2	31571198	31571198	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtgggtcagcagcacagagCcatctgtgtacacatgaagt	12	10	2	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr2:31571198C>T	uc002rnv.1	-	28	3162	c.3083G>A	c.(3082-3084)GGC>GAC	p.G1028D		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1028					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CAGCACAGAGCCATCTGTGTA	0.517													T	31571198	T	T	31571198	3	4	262	1	0	0	0	0	1	0	0	0	17423	739	26	3	954	3	XDH	2	31571198	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08		31571198	211628175	9	18791											
SERTAD2	9792	broad.mit.edu	37	chr2	64863694	64863694	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaggtggctgaaggccggCggggcctctcggtagctgtc	18	12	1	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr2:64863694C>T	uc002sde.1	-	2	609	c.312G>A	c.(310-312)CCG>CCA	p.P104P		NM_014755	NP_055570	Q14140	SRTD2_HUMAN	SERTA domain containing 2	104					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus					0						TGAAGGCCGGCGGGGCCTCTC	0.697													T	64863694	T	T	64863694	2	4	262	1	0	0	0	0	0	0	0	1	14121	755	27	1		1	SERTAD2	2	64863694	Silent	SNP	C	TCGA-76-4931-01A-01D-1486-08	33292496	64863694	178335679	10	18792											
TTN	7273	broad.mit.edu	37	chr2	179474028	179474028	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcaggtcggagagaatctcGgacgcgtagctgagattctc	14	9	3	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr2:179474028G>A	uc010zfg.1	-	222	44529	c.44305C>T	c.(44305-44307)CGA>TGA	p.R14769*	uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.R8464*|TTN_uc010zfi.1_Nonsense_Mutation_p.R8397*|TTN_uc010zfj.1_Nonsense_Mutation_p.R8272*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15696							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGAATCTCGGACGCGTAGC	0.453													A	179474028	A	A	179474028	4	1	262	1	0	0	0	0	0	1	0	0	16732	1124	39	2	56044	2	TTN	2	179474028	Nonsense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	114610334	179474028	63725345	11	18793											
ZFP42	132625	broad.mit.edu	37	chr4	188924640	188924640	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggaatgtgggaaagcgttcGttgagagctcaaaactaaag	13	6	1	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr4:188924640G>A	uc003izg.1	+	3	924	c.679G>A	c.(679-681)GTT>ATT	p.V227I	ZFP42_uc003izh.1_Missense_Mutation_p.V227I|ZFP42_uc003izi.1_Missense_Mutation_p.V227I	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	227	C2H2-type 2.				female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GAAAGCGTTCGTTGAGAGCTC	0.502													A	188924640	A	A	188924640	3	1	262	1	0	0	0	0	1	0	0	0	17647	1145	40	1	681	1	ZFP42	4	188924640	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08		188924640	2229636	12	18794											
PCDHB12	56124	broad.mit.edu	37	chr5	140590123	140590123	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcagcgaggcgctggtgcgCgtgctggtgctggacgccaa	18	11	0	0	rs147374257		TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr5:140590123C>T	uc003liz.2	+	1	1833	c.1644C>T	c.(1642-1644)CGC>CGT	p.R548R	PCDHB12_uc011dak.1_Silent_p.R211R	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	548	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCTGGTGCGCGTGCTGGTGC	0.711													T	140590123	T	T	140590123	2	4	262	1	0	0	0	0	0	0	0	1	11537	755	27	1		1	PCDHB12	5	140590123	Silent	SNP	C	TCGA-76-4931-01A-01D-1486-08		140590123	40325137	13	18795											
GABRA6	2559	broad.mit.edu	37	chr5	161113339	161113339	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaggctatgacaatcggctgCggccgggatttggaggtaag	16	7	0	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr5:161113339C>T	uc003lyu.2	+	2	480	c.142C>T	c.(142-144)CGG>TGG	p.R48W		NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	48	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAATCGGCTGCGGCCGGGATT	0.483										TCGA Ovarian(5;0.080)			T	161113339	T	T	161113339	3	4	262	1	0	0	0	0	1	0	0	0	6165	759	27	1	148	1	GABRA6	5	161113339	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	20523216	161113339	19801921	14	18796											
MICALL2	79778	broad.mit.edu	37	chr7	1485031	1485031	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctcctgtggccttgtaggcCcccgagtgcagcgtgcagga	14	13	1	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr7:1485031C>T	uc003skj.3	-	6	822	c.675G>A	c.(673-675)GGG>GGA	p.G225G	MICALL2_uc003ski.3_5'Flank	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	225	LIM zinc-binding.					cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CCTTGTAGGCCCCCGAGTGCA	0.692													T	1485031	T	T	1485031	2	4	262	1	0	0	0	0	0	0	0	1	9574	610	22	3		3	MICALL2	7	1485031	Silent	SNP	C	TCGA-76-4931-01A-01D-1486-08		1485031	157653632	15	18797											
CARD11	84433	broad.mit.edu	37	chr7	2984147	2984147	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cctcgttcatcaggaagtgcGtgaggccctcgtggccttcc	12	14	2	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr7:2984147G>C	uc003smv.2	-	5	787	c.383C>G	c.(382-384)ACG>AGG	p.T128R		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	128					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity	p.T121M(2)		haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CAGGAAGTGCGTGAGGCCCTC	0.622			Mis		DLBCL								C	2984147	C	C	2984147	3	2	262	1	0	0	0	0	1	0	0	0	2645	1145	40	5	3165	5	CARD11	7	2984147	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	1499116	2984147	156154516	16	18798											
EGFR	1956	broad.mit.edu	37	chr7	55233043	55233043	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	cgtcaagacctgcccggcagGagtcatgggagaaaacaaca	12	11	2	2	rs139236063		TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr7:55233043G>T	uc003tqk.2	+	15	2039	c.1793G>T	c.(1792-1794)GGA>GTA	p.G598V	EGFR_uc003tqi.2_Missense_Mutation_p.G598V|EGFR_uc003tqj.2_Missense_Mutation_p.G598V|EGFR_uc010kzg.1_Missense_Mutation_p.G553V|EGFR_uc011kco.1_Missense_Mutation_p.G545V|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	598	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.G598V(16)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCCCGGCAGGAGTCATGGGA	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55233043	T	T	55233043	3	4	262	1	0	0	0	0	1	0	0	0	4967	1174	41	5	1862	5	EGFR	7	55233043	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	52248896	55233043	103905620	17	18799											
PIK3CG	5294	broad.mit.edu	37	chr7	106508432	106508432	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacctggtgcagcggcacccGccctccgaggagtcccaagc	12	18	0	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr7:106508432G>A	uc003vdv.3	+	2	511	c.426G>A	c.(424-426)CCG>CCA	p.P142P	PIK3CG_uc003vdu.2_Silent_p.P142P|PIK3CG_uc003vdw.2_Silent_p.P142P	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	142					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						AGCGGCACCCGCCCTCCGAGG	0.637													A	106508432	A	A	106508432	2	1	262	1	0	0	0	0	0	0	0	1	11916	1074	38	1		1	PIK3CG	7	106508432	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08	51275389	106508432	52630231	18	18800											
ADAM2	2515	broad.mit.edu	37	chr8	39613418	39613418	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatttacatattaattttccGcactgcagattgctataatt	4	7	0	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr8:39613418G>A	uc003xnj.2	-	16	1701	c.1626C>T	c.(1624-1626)TGC>TGT	p.C542C	ADAM2_uc003xnk.2_Silent_p.C523C|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Intron	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	542	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TTAATTTTCCGCACTGCAGAT	0.249													A	39613418	A	A	39613418	2	1	262	1	0	0	0	0	0	0	0	1	241	1079	38	1		1	ADAM2	8	39613418	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08		39613418	106750604	19	18801											
LMX1B	4010	broad.mit.edu	37	chr9	129453336	129453336	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagctccgtgagccccgacgAgtccgactccggtgaggcct	13	16	0	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr9:129453336A>G	uc004bqj.2	+	3	529	c.479A>G	c.(478-480)GAG>GGG	p.E160G	LMX1B_uc004bqi.2_Missense_Mutation_p.E160G|LMX1B_uc011maa.1_Missense_Mutation_p.E160G	NM_002316	NP_002307	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	160					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCCCCGACGAGTCCGACTCC	0.667									Nail-Patella_Syndrome				G	129453336	G	G	129453336	3	3	262	1	0	0	0	0	1	0	0	0	8862	304	11	4	558	4	LMX1B	9	129453336	Missense_Mutation	SNP	A	TCGA-76-4931-01A-01D-1486-08		129453336	11760095	20	18802											
PTEN	5728	broad.mit.edu	37	chr10	89712007	89712007	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctattccaatgttcagtggcGgaacttgcagtaagtgcttg	11	8	1	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr10:89712007G>T	uc001kfb.2	+	7	1656	c.625G>T	c.(625-627)GGA>TGA	p.G209*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	209	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(3)|p.G165fs*9(3)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G165_K342del(1)|p.G165_*404del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GTTCAGTGGCGGAACTTGCAG	0.328		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89712007	T	T	89712007	4	4	262	1	0	0	0	0	0	1	0	0	12738	1117	39	5	647	5	PTEN	10	89712007	Nonsense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08		89712007	45822740	21	18803											
SMC3	9126	broad.mit.edu	37	chr10	112350788	112350788	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gattcagatgaagtcagcacGaagattttaatggagtttaa	10	4	2	3			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr10:112350788G>A	uc001kze.2	+	17	1836	c.1710G>A	c.(1708-1710)ACG>ACA	p.T570T		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	570	Flexible hinge.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		AAGTCAGCACGAAGATTTTAA	0.363													A	112350788	A	A	112350788	2	1	262	1	0	0	0	0	0	0	0	1	14784	1045	37	2		2	SMC3	10	112350788	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08	22638781	112350788	23183959	22	18804											
TRIM44	54765	broad.mit.edu	37	chr11	35747531	35747531	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tttaagaaagttcagaaagtGattgctgatgaggagcagaa	12	3	1	6			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr11:35747531G>A	uc001mwi.2	+	3	1114	c.807G>A	c.(805-807)GTG>GTA	p.V269V		NM_017583	NP_060053	Q96DX7	TRI44_HUMAN	DIPB protein	269						intracellular	protein binding|zinc ion binding			skin(1)	1	all_lung(20;0.0317)|Lung NSC(22;0.0661)|all_epithelial(35;0.115)	all_hematologic(20;0.107)				TTCAGAAAGTGATTGCTGATG	0.423													A	35747531	A	A	35747531	2	1	262	1	0	0	0	0	0	0	0	1	16516	1277	45	3		3	TRIM44	11	35747531	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08		35747531	99258985	23	18805											
MS4A14	84689	broad.mit.edu	37	chr11	60183896	60183896	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaagaaaatcctcaagacgGcattccttaaaccagcaaac	6	11	1	3			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr11:60183896G>A	uc001npj.2	+	5	2020	c.1455G>A	c.(1453-1455)CGG>CGA	p.R485R	MS4A14_uc001npi.2_Silent_p.R373R|MS4A14_uc001npn.2_Silent_p.R223R|MS4A14_uc001npk.2_Silent_p.R468R|MS4A14_uc001npl.2_Silent_p.R223R|MS4A14_uc001npm.2_Silent_p.R223R	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	485	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						CCTCAAGACGGCATTCCTTAA	0.393													A	60183896	A	A	60183896	2	1	262	1	0	0	0	0	0	0	0	1	9858	1190	42	3		3	MS4A14	11	60183896	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08	24436365	60183896	74822620	24	18806											
PRPF19	27339	broad.mit.edu	37	chr11	60665709	60665709	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cgatgctagtgatggggcccGagtggccagggaagttggcc	18	9	0	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr11:60665709G>A	uc001nqf.2	-	14	1382	c.1175C>T	c.(1174-1176)TCG>TTG	p.S392L		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	PRP19/PSO4 pre-mRNA processing factor 19	392	WD 5.				DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						GATGGGGCCCGAGTGGCCAGG	0.532													A	60665709	A	A	60665709	3	1	262	1	0	0	0	0	1	0	0	0	12564	1059	37	2	351	2	PRPF19	11	60665709	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	481813	60665709	74340807	25	18807											
HEPHL1	341208	broad.mit.edu	37	chr11	93778980	93778980	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ggattcctgggccccatcttGagggccgaagtgggtgatgt	16	9	1	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr11:93778980G>A	uc001pep.2	+	2	469	c.312G>A	c.(310-312)TTG>TTA	p.L104L		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	104	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GCCCCATCTTGAGGGCCGAAG	0.468													A	93778980	A	A	93778980	2	1	262	1	0	0	0	0	0	0	0	1	7055	1281	45	3		3	HEPHL1	11	93778980	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08	33113271	93778980	41227536	26	18808											
OR10G8	219869	broad.mit.edu	37	chr11	123900691	123900691	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagggtcatgtcctgtgatcGctacctggccatcagttacc	10	13	2	1	rs116699538	byFrequency	TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr11:123900691G>A	uc001pzp.1	+	1	362	c.362G>A	c.(361-363)CGC>CAC	p.R121H		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TCCTGTGATCGCTACCTGGCC	0.567													A	123900691	A	A	123900691	3	1	262	1	0	0	0	0	1	0	0	0	10903	1087	38	1	364	1	OR10G8	11	123900691	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	30121711	123900691	11105825	27	18809											
DENND5B	160518	broad.mit.edu	37	chr12	31545306	31545306	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggccattttctccacacaGcaacacggtgaggcttcctc	8	15	1	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr12:31545306G>A	uc001rki.1	-	19	3547	c.3361C>T	c.(3361-3363)CTG>TTG	p.L1121L	DENND5B_uc001rkh.1_Silent_p.L1156L|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1121	RUN 2.					integral to membrane				ovary(1)|central_nervous_system(1)	2						TCTCCACACAGCAACACGGTG	0.468													A	31545306	A	A	31545306	2	1	262	1	0	0	0	0	0	0	0	1	4437	962	34	3		3	DENND5B	12	31545306	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08		31545306	102306589	28	18810											
OR6C6	283365	broad.mit.edu	37	chr12	55688853	55688853	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagaaagaaatacattggcGtcttgagccggggatccagc	14	8	1	3	rs77411445		TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr12:55688853G>A	uc010sph.1	-	1	164	c.164C>T	c.(163-165)ACG>ATG	p.T55M		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						ATACATTGGCGTCTTGAGCCG	0.398													A	55688853	A	A	55688853	3	1	262	1	0	0	0	0	1	0	0	0	11194	1145	40	1	782	1	OR6C6	12	55688853	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	24143547	55688853	78163042	29	18811											
AVPR1A	552	broad.mit.edu	37	chr12	63543656	63543656	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccggcacgtaccggtccagaCggacatgggatcccagacag	13	14	0	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr12:63543656C>T	uc001sro.1	-	1	2935	c.961G>A	c.(961-963)GTC>ATC	p.V321I		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	321	Extracellular (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCGGTCCAGACGGACATGGGA	0.403													T	63543656	T	T	63543656	3	4	262	1	0	0	0	0	1	0	0	0	1231	536	19	1	303	1	AVPR1A	12	63543656	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	7854803	63543656	70308239	30	18812											
GPR12	2835	broad.mit.edu	37	chr13	27332980	27332980	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctacacatcactgggcgagcGcgctctctgggcgagactgg	14	13	2	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr13:27332980G>A	uc010aal.2	-	2	1207	c.985C>T	c.(985-987)CGC>TGC	p.R329C	GPR12_uc010tdl.1_Missense_Mutation_p.R170C	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	329	Cytoplasmic (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		CTGGGCGAGCGCGCTCTCTGG	0.537													A	27332980	A	A	27332980	3	1	262	1	0	0	0	0	1	0	0	0	6635	1087	38	1	23	1	GPR12	13	27332980	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08		27332980	87836898	31	18813											
ADCY4	196883	broad.mit.edu	37	chr14	24795366	24795366	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catctagtccccggggggtaCggctcctgcacagtgagagc	14	13	1	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr14:24795366C>T	uc001wov.2	-	12	1580	c.1574G>A	c.(1573-1575)CGT>CAT	p.R525H	ADCY4_uc001wow.2_Missense_Mutation_p.R525H|ADCY4_uc010toh.1_Missense_Mutation_p.R211H|ADCY4_uc001wox.2_Missense_Mutation_p.R525H|ADCY4_uc001woy.2_Missense_Mutation_p.R525H	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	525	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		CCGGGGGGTACGGCTCCTGCA	0.592													T	24795366	T	T	24795366	3	4	262	1	0	0	0	0	1	0	0	0	296	536	19	1	1715	1	ADCY4	14	24795366	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08		24795366	82554174	32	18814											
GALC	2581	broad.mit.edu	37	chr14	88431916	88431916	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctgggccgtcatcaacccGcatctcccataaggcaactg	8	16	3	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr14:88431916G>A	uc001xvt.2	-	9	1365	c.966C>T	c.(964-966)TGC>TGT	p.C322C	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Silent_p.C296C|GALC_uc010tvy.1_Silent_p.C299C|GALC_uc010tvz.1_Silent_p.C266C|GALC_uc001xvu.1_Silent_p.C322C	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	322					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						TCATCAACCCGCATCTCCCAT	0.448													A	88431916	A	A	88431916	2	1	262	1	0	0	0	0	0	0	0	1	6201	1079	38	1		1	GALC	14	88431916	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08	63636550	88431916	18917624	33	18815											
AHNAK2	113146	broad.mit.edu	37	chr14	105415138	105415138	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctccaggagtttcacgtccAcctggccagcctggaccttc	9	17	1	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr14:105415138A>C	uc010axc.1	-	7	6770	c.6650T>G	c.(6649-6651)GTG>GGG	p.V2217G	AHNAK2_uc001ypx.2_Missense_Mutation_p.V2117G	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2217						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTTCACGTCCACCTGGCCAGC	0.627													C	105415138	C	C	105415138	3	2	262	1	0	0	0	0	1	0	0	0	415	159	6	5	10741	5	AHNAK2	14	105415138	Missense_Mutation	SNP	A	TCGA-76-4931-01A-01D-1486-08	16983222	105415138	1934402	34	18816											
MKRN3	7681	broad.mit.edu	37	chr15	23810982	23810982	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaggcagccggggcccaggCaggtgctgaggcagcaaggg	20	11	0	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr15:23810982C>T	uc001ywh.3	+	1	529	c.53C>T	c.(52-54)GCA>GTA	p.A18V	MKRN3_uc001ywi.2_Missense_Mutation_p.A18V|MKRN3_uc010ayi.1_Missense_Mutation_p.A18V	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	18						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGGGCCCAGGCAGGTGCTGAG	0.637													T	23810982	T	T	23810982	3	4	262	1	0	0	0	0	1	0	0	0	9608	710	25	3	55	3	MKRN3	15	23810982	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08		23810982	78720410	35	18817											
NEO1	4756	broad.mit.edu	37	chr15	73562540	73562540	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgatactacaccgtccgatGgaaaaccaacatcccagcaa	6	15	0	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr15:73562540G>A	uc002avm.3	+	17	2826	c.2684G>A	c.(2683-2685)TGG>TAG	p.W895*	NEO1_uc010ukx.1_Nonsense_Mutation_p.W895*|NEO1_uc010uky.1_Nonsense_Mutation_p.W895*|NEO1_uc010ukz.1_Nonsense_Mutation_p.W319*|NEO1_uc002avn.3_Nonsense_Mutation_p.W544*	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	895	Extracellular (Potential).|Fibronectin type-III 5.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						ACCGTCCGATGGAAAACCAAC	0.448													A	73562540	A	A	73562540	4	1	262	1	0	0	0	0	0	1	0	0	10336	1357	47	3	2750	3	NEO1	15	73562540	Nonsense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	49751558	73562540	28968852	36	18818											
NOMO1	23420	broad.mit.edu	37	chr16	14968903	14968903	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tttcttctaggtcttccatcGacagtgaacccgccttggtc	8	13	3	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr16:14968903G>A	uc002dcv.2	+	19	2131	c.2065G>A	c.(2065-2067)GAC>AAC	p.D689N		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	689	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						GTCTTCCATCGACAGTGAACC	0.562													A	14968903	A	A	14968903	3	1	262	1	0	0	0	0	1	0	0	0	10531	1058	37	2	2139	2	NOMO1	16	14968903	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08		14968903	75385850	37	18819											
SCNN1B	6338	broad.mit.edu	37	chr16	23366788	23366788	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatcctggcctgcctattcGgagctgagccctgcaactac	10	14	0	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr16:23366788G>A	uc002dln.2	+	4	930	c.754G>A	c.(754-756)GGA>AGA	p.G252R		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	252	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CTGCCTATTCGGAGCTGAGCC	0.488													A	23366788	A	A	23366788	3	1	262	1	0	0	0	0	1	0	0	0	13928	1117	39	2	764	2	SCNN1B	16	23366788	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	8397885	23366788	66987965	38	18820											
ATP2A1	487	broad.mit.edu	37	chr16	28914740	28914740	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgacgaaatcctcaagttcGttgctcggaactacctagag	9	11	1	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr16:28914740G>A	uc002dro.1	+	21	3143	c.2959G>A	c.(2959-2961)GTT>ATT	p.V987I	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.V987I|ATP2A1_uc002drp.1_Missense_Mutation_p.V862I	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	987	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCTCAAGTTCGTTGCTCGGAA	0.522													A	28914740	A	A	28914740	3	1	262	1	0	0	0	0	1	0	0	0	1136	1145	40	1	3041	1	ATP2A1	16	28914740	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	5547952	28914740	61440013	39	18821											
C17orf87	388325	broad.mit.edu	37	chr17	5118261	5118261	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aattcctcggtggcagaggcGgtaattgaactggcgactca	13	9	1	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr17:5118261G>A	uc002gbh.2	-	4	275	c.242C>T	c.(241-243)CCG>CTG	p.P81L	uc002gbf.1_Intron|uc002gbg.1_Intron|C17orf87_uc010clb.1_Missense_Mutation_p.P74L|C17orf87_uc002gbi.2_Missense_Mutation_p.P74L	NM_207103	NP_996986	Q6UWF3	CQ087_HUMAN	hypothetical protein LOC388325	81						integral to membrane				ovary(1)	1						TGGCAGAGGCGGTAATTGAAC	0.433													A	5118261	A	A	5118261	3	1	262	1	0	0	0	0	1	0	0	0	1889	1116	39	2	203	2	C17orf87	17	5118261	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08		5118261	76076949	40	18822											
DNAH2	146754	broad.mit.edu	37	chr17	7722376	7722376	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatcaacactgacttggcgCgggaggtaagctcccggccc	13	13	1	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr17:7722376C>T	uc002giu.1	+	70	10824	c.10810C>T	c.(10810-10812)CGG>TGG	p.R3604W	DNAH2_uc010cnm.1_Missense_Mutation_p.R542W	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3604					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGACTTGGCGCGGGAGGTAAG	0.607													T	7722376	T	T	7722376	3	4	262	1	0	0	0	0	1	0	0	0	4602	759	27	1	11088	1	DNAH2	17	7722376	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	2604115	7722376	73472834	41	18823											
KRT33A	3883	broad.mit.edu	37	chr17	39506774	39506774	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggatgaggttctccagctcCgcgttgtcccgctccagctg	12	15	1	1	rs61736449	byFrequency	TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr17:39506774C>T	uc002hwk.1	-	1	283	c.246G>A	c.(244-246)GCG>GCA	p.A82A		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	82	Coil 1A.|Rod.			A -> T (in Ref. 3; BAG36784).		intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TCTCCAGCTCCGCGTTGTCCC	0.602													T	39506774	T	T	39506774	2	4	262	1	0	0	0	0	0	0	0	1	8469	639	23	2		2	KRT33A	17	39506774	Silent	SNP	C	TCGA-76-4931-01A-01D-1486-08	31784398	39506774	41688436	42	18824											
ZNF516	9658	broad.mit.edu	37	chr18	74153649	74153649	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctcaccaggacgtactcGcgcctgtccttgtcgaaggc	12	14	1	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr18:74153649G>A	uc010dqx.1	-	2	1597	c.1362C>T	c.(1360-1362)CGC>CGT	p.R454R	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	454					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGACGTACTCGCGCCTGTCCT	0.731													A	74153649	A	A	74153649	2	1	262	1	0	0	0	0	0	0	0	1	17957	1074	38	1		1	ZNF516	18	74153649	Silent	SNP	G	TCGA-76-4931-01A-01D-1486-08		74153649	3923599	43	18825											
GRIN3B	116444	broad.mit.edu	37	chr19	1005285	1005285	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcgctcttcctcaccgtgtaCgagtggcgtagcccctacgg	12	15	2	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr19:1005285C>T	uc002lqo.1	+	3	1785	c.1785C>T	c.(1783-1785)TAC>TAT	p.Y595Y		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	595	Cytoplasmic (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	TCACCGTGTACGAGTGGCGTA	0.652													T	1005285	T	T	1005285	2	4	262	1	0	0	0	0	0	0	0	1	6784	547	19	1		1	GRIN3B	19	1005285	Silent	SNP	C	TCGA-76-4931-01A-01D-1486-08		1005285	58123698	44	18826											
DENND1C	79958	broad.mit.edu	37	chr19	6472910	6472910	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctggcatacctgtttgaacAgctgcaggtgcacagcccgc	11	13	1	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr19:6472910A>C	uc002mfe.2	-	15	1240	c.1148T>G	c.(1147-1149)CTG>CGG	p.L383R	DENND1C_uc002mfb.2_5'UTR|DENND1C_uc002mfc.2_5'UTR|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Missense_Mutation_p.L339R	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	383	dDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						CTGTTTGAACAGCTGCAGGTG	0.627													C	6472910	C	C	6472910	3	2	262	1	0	0	0	0	1	0	0	0	4428	188	7	5	1293	5	DENND1C	19	6472910	Missense_Mutation	SNP	A	TCGA-76-4931-01A-01D-1486-08	5467625	6472910	52656073	45	18827											
CD209	30835	broad.mit.edu	37	chr19	7809880	7809880	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccccacttctttgcaggCggtgatggagtcgtgccagt	14	12	1	1	rs139712001	byFrequency	TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr19:7809880C>T	uc002mht.2	-	5	914	c.847G>A	c.(847-849)GCC>ACC	p.A283T	CD209_uc010xju.1_Missense_Mutation_p.A122T|CD209_uc010dvp.2_Missense_Mutation_p.A259T|CD209_uc002mhr.2_Missense_Mutation_p.A259T|CD209_uc002mhs.2_Missense_Mutation_p.A213T|CD209_uc002mhu.2_Missense_Mutation_p.A191T|CD209_uc010dvq.2_Missense_Mutation_p.A283T|CD209_uc002mhq.2_Missense_Mutation_p.A283T|CD209_uc002mhv.2_Missense_Mutation_p.A259T|CD209_uc002mhx.2_Missense_Mutation_p.A239T|CD209_uc002mhw.2_Missense_Mutation_p.A147T|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	283	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						TCTTTGCAGGCGGTGATGGAG	0.582													T	7809880	T	T	7809880	3	4	262	1	0	0	0	0	1	0	0	0	2984	768	27	1	379	1	CD209	19	7809880	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	1336970	7809880	51319103	46	18828											
ZNF761	388561	broad.mit.edu	37	chr19	53959098	53959098	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgtaatgagtgtggaaagaCctttagccggacatcatccc	11	9	1	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr19:53959098C>T	uc010eqp.2	+	7	1795	c.1337C>T	c.(1336-1338)ACC>ATC	p.T446I	ZNF761_uc010ydy.1_Missense_Mutation_p.T392I|ZNF761_uc002qbt.1_Missense_Mutation_p.T392I	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	446	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TGTGGAAAGACCTTTAGCCGG	0.383													T	53959098	T	T	53959098	3	4	262	1	0	0	0	0	1	0	0	0	18133	507	18	3	1348	3	ZNF761	19	53959098	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	46149218	53959098	5169885	47	18829											
CEP250	11190	broad.mit.edu	37	chr20	34092288	34092288	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gtgagatccaggaccaggatCtccgataccaggaggatgtg	14	9	1	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr20:34092288C>G	uc002xcm.2	+	31	6762	c.6091C>G	c.(6091-6093)CTC>GTC	p.L2031V	CEP250_uc010zve.1_Missense_Mutation_p.L1399V	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	2031	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGACCAGGATCTCCGATACCA	0.597													G	34092288	G	G	34092288	3	3	262	1	0	0	0	0	1	0	0	0	3252	913	32	5	6197	5	CEP250	20	34092288	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08		34092288	28933232	48	18830											
SUSD2	56241	broad.mit.edu	37	chr22	24579586	24579586	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcactggacaacggccactcCttccctcgtgcgggcacctg	10	17	1	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr22:24579586C>T	uc002zzn.1	+	3	455	c.411C>T	c.(409-411)TCC>TCT	p.S137S		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	137	Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ACGGCCACTCCTTCCCTCGTG	0.642													T	24579586	T	T	24579586	2	4	262	1	0	0	0	0	0	0	0	1	15405	668	24	3		3	SUSD2	22	24579586	Silent	SNP	C	TCGA-76-4931-01A-01D-1486-08		24579586	26724980	49	18831											
CCDC157	550631	broad.mit.edu	37	chr22	30766543	30766543	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actcccagaccattgagacgGccctggtgccctgtgacgca	11	15	0	3			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr22:30766543G>A	uc011aku.1	+	5	1309	c.649G>A	c.(649-651)GCC>ACC	p.A217T	CCDC157_uc011akv.1_Missense_Mutation_p.A217T	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	coiled-coil domain containing 157	217										central_nervous_system(1)	1						CATTGAGACGGCCCTGGTGCC	0.622													A	30766543	A	A	30766543	3	1	262	1	0	0	0	0	1	0	0	0	2789	1203	42	3	659	3	CCDC157	22	30766543	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	6186957	30766543	20538023	50	18832											
GAL3ST1	9514	broad.mit.edu	37	chr22	30951178	30951178	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggcgtggcccccgtcgatgCagatggtccgcatgcgctcg	15	15	0	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chr22:30951178C>T	uc003aig.1	-	4	1174	c.1034G>A	c.(1033-1035)TGC>TAC	p.C345Y	GAL3ST1_uc003aih.1_Missense_Mutation_p.C345Y|GAL3ST1_uc003aii.1_Missense_Mutation_p.C345Y|GAL3ST1_uc010gvz.1_Missense_Mutation_p.C345Y	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	345	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CCCGTCGATGCAGATGGTCCG	0.711													T	30951178	T	T	30951178	3	4	262	1	0	0	0	0	1	0	0	0	6197	710	25	3	241	3	GAL3ST1	22	30951178	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	184635	30951178	20353388	51	18833											
GYG2	8908	broad.mit.edu	37	chrX	2799104	2799104	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttccctaggtcgacctggcCgtctctgtttcccagatctc	8	16	2	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chrX:2799104C>T	uc004cqs.1	+	12	1638	c.1356C>T	c.(1354-1356)GCC>GCT	p.A452A	GYG2_uc004cqt.1_Silent_p.A421A|GYG2_uc004cqu.1_Silent_p.A420A|GYG2_uc004cqv.1_Silent_p.A195A|GYG2_uc004cqw.1_Silent_p.A412A|GYG2_uc004cqx.1_Silent_p.A350A|GYG2_uc010ndc.1_Silent_p.A230A	NM_003918	NP_003909	O15488	GLYG2_HUMAN	glycogenin 2 isoform b	452					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			ovary(1)|kidney(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCGACCTGGCCGTCTCTGTTT	0.542													T	2799104	T	T	2799104	2	4	262	1	0	0	0	0	0	0	0	1	6906	639	23	2		2	GYG2	23	2799104	Silent	SNP	C	TCGA-76-4931-01A-01D-1486-08		2799104	152471456	52	18834											
ASB9	140462	broad.mit.edu	37	chrX	15266989	15266989	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	catgagcaggcaggccagctCttcactggctgtcctggcca	12	14	2	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chrX:15266989C>A	uc004cwl.2	-	6	884	c.637G>T	c.(637-639)GAG>TAG	p.E213*	ASB9_uc004cwk.2_Nonsense_Mutation_p.E213*|ASB9_uc004cwm.2_Nonsense_Mutation_p.E203*|ASB9_uc010ner.2_Nonsense_Mutation_p.E213*|ASB9_uc004cwn.2_Nonsense_Mutation_p.E184*	NM_001031739	NP_001026909	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box-containing 9 isoform	213	ANK 6.				intracellular signal transduction						0	Hepatocellular(33;0.183)					CAGGCCAGCTCTTCACTGGCT	0.567													A	15266989	A	A	15266989	4	1	262	1	0	0	0	0	0	1	0	0	1030	922	32	5	284	5	ASB9	23	15266989	Nonsense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	12467885	15266989	140003571	53	18835											
APEX2	27301	broad.mit.edu	37	chrX	55032975	55032975	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctttgaagaggacccagggCgcaagtggatggacagcttg	16	8	0	2			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chrX:55032975C>T	uc004dtz.2	+	6	740	c.664C>T	c.(664-666)CGC>TGC	p.R222C	APEX2_uc011mom.1_Missense_Mutation_p.R51C	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	222					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						GGACCCAGGGCGCAAGTGGAT	0.473								Other_BER_factors					T	55032975	T	T	55032975	3	4	262	1	0	0	0	0	1	0	0	0	770	768	27	1	686	1	APEX2	23	55032975	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	39765986	55032975	100237585	54	18836											
ACRC	93953	broad.mit.edu	37	chrX	70830605	70830605	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttatgcagcactggtgagatGtggtacccaaagtggcggcg	15	8	0	1			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chrX:70830605G>A	uc004eae.2	+	11	2187	c.1686G>A	c.(1684-1686)ATG>ATA	p.M562I	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	562						nucleus				ovary(3)	3	Renal(35;0.156)					CTGGTGAGATGTGGTACCCAA	0.502													A	70830605	A	A	70830605	3	1	262	1	0	0	0	0	1	0	0	0	171	1377	48	3	1724	3	ACRC	23	70830605	Missense_Mutation	SNP	G	TCGA-76-4931-01A-01D-1486-08	15797630	70830605	84439955	55	18837											
HCFC1	3054	broad.mit.edu	37	chrX	153236126	153236126	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtacacgtgcagttcgtccaCtattccctcgttgccgccgc	9	16	0	0			TCGA-76-4931-01A-01D-1486-08	TCGA-76-4931-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	d4a27742-ca69-4f54-9bce-ec33d8481fed	e6b4bc27-ebe2-4ee8-bb89-dbb23d77870c	g.chrX:153236126C>G	uc004fjp.2	-	1	694	c.166G>C	c.(166-168)GTG>CTG	p.V56L	TMEM187_uc004fjq.2_5'Flank	NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	56	Kelch 1.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTTCGTCCACTATTCCCTCG	0.532													G	153236126	G	G	153236126	3	3	262	1	0	0	0	0	1	0	0	0	6991	565	20	5	6045	5	HCFC1	23	153236126	Missense_Mutation	SNP	C	TCGA-76-4931-01A-01D-1486-08	82405521	153236126	2034434	56	18838											
MEGF6	1953	broad.mit.edu	37	chr1	3425698	3425698	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctcttcctcatcggccccgAcgtcgtcatcctggaagagt	9	16	3	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr1:3425698A>G	uc001akl.2	-	12	1696	c.1469T>C	c.(1468-1470)GTC>GCC	p.V490A	MEGF6_uc001akk.2_Missense_Mutation_p.V385A	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	490						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		ATCGGCCCCGACGTCGTCATC	0.682													G	3425698	G	G	3425698	3	3	263	1	0	0	0	0	1	0	0	0	9462	275	10	4	3260	4	MEGF6	1	3425698	Missense_Mutation	SNP	A	TCGA-76-4932-01A-01D-1486-08		3425698	245824923	1	18839											
SNX7	51375	broad.mit.edu	37	chr1	99203845	99203845	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggaatgtgctaataatgCcctgaaagcagattgggaga	13	5	0	3			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr1:99203845C>T	uc010ouc.1	+	8	1230	c.1178C>T	c.(1177-1179)GCC>GTC	p.A393V	SNX7_uc001dsa.2_Intron|SNX7_uc010oud.1_Missense_Mutation_p.A338V	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	329					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		GCTAATAATGCCCTGAAAGCA	0.348													T	99203845	T	T	99203845	3	4	263	1	0	0	0	0	1	0	0	0	14907	739	26	3	1208	3	SNX7	1	99203845	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	95778147	99203845	150046776	2	18840											
AMPD2	271	broad.mit.edu	37	chr1	110172108	110172108	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggccatgttgaaccacctgCgcaggtgcctgcaccaccct	10	16	0	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr1:110172108C>T	uc009wfh.1	+	15	2562	c.2020C>T	c.(2020-2022)CGC>TGC	p.R674C	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Missense_Mutation_p.R593C|AMPD2_uc001dyc.1_Missense_Mutation_p.R674C|AMPD2_uc010ovr.1_Missense_Mutation_p.R599C|AMPD2_uc001dyd.1_Missense_Mutation_p.R555C|AMPD2_uc001dye.1_5'UTR	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	674					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		GAACCACCTGCGCAGGTGCCT	0.602													T	110172108	T	T	110172108	3	4	263	1	0	0	0	0	1	0	0	0	586	768	27	1	2115	1	AMPD2	1	110172108	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	10968263	110172108	139078513	3	18841											
FLG	2312	broad.mit.edu	37	chr1	152281686	152281686	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcgagtgtctagagctgtcGgcccgagaggaagcttcatg	15	9	2	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr1:152281686G>A	uc001ezu.1	-	3	5712	c.5676C>T	c.(5674-5676)GCC>GCT	p.A1892A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1892	Ser-rich.|Filaggrin 11.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGAGCTGTCGGCCCGAGAGG	0.572									Ichthyosis				A	152281686	A	A	152281686	2	1	263	1	0	0	0	0	0	0	0	1	5922	1103	39	2		2	FLG	1	152281686	Silent	SNP	G	TCGA-76-4932-01A-01D-1486-08	42109578	152281686	96968935	4	18842											
LELP1	149018	broad.mit.edu	37	chr1	153177307	153177307	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttaaagaagctgctgcaaCgctgtttcgaaaagtgccca	10	9	0	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr1:153177307C>T	uc001fbl.2	+	2	234	c.124C>T	c.(124-126)CGC>TGC	p.R42C		NM_001010857	NP_001010857	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	42	Cys/Pro-rich.									ovary(1)	1	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCTGCTGCAACGCTGTTTCGA	0.552													T	153177307	T	T	153177307	3	4	263	1	0	0	0	0	1	0	0	0	8718	536	19	1	126	1	LELP1	1	153177307	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	895621	153177307	96073314	5	18843											
NUP210L	91181	broad.mit.edu	37	chr1	154067448	154067448	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcattggatccggtagatgTactggttctgttttctctta	11	7	2	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr1:154067448T>C	uc001fdw.2	-	15	2222	c.2150A>G	c.(2149-2151)TAC>TGC	p.Y717C	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.Y717C	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	717						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CCGGTAGATGTACTGGTTCTG	0.398													C	154067448	C	C	154067448	3	2	263	1	0	0	0	0	1	0	0	0	10761	1638	57	4	3620	4	NUP210L	1	154067448	Missense_Mutation	SNP	T	TCGA-76-4932-01A-01D-1486-08	890141	154067448	95183173	6	18844											
ANGEL2	90806	broad.mit.edu	37	chr1	213181756	213181756	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttttgtctcctaggatcttCgttttttctttatcatggct	6	8	4	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr1:213181756C>T	uc001hjz.2	-	3	593	c.438G>A	c.(436-438)ACG>ACA	p.T146T	ANGEL2_uc010pto.1_Silent_p.T20T|ANGEL2_uc010ptp.1_Silent_p.T20T|ANGEL2_uc001hka.2_5'UTR|ANGEL2_uc010ptq.1_RNA|ANGEL2_uc001hkb.2_Silent_p.T124T	NM_144567	NP_653168	Q5VTE6	ANGE2_HUMAN	LOC90806 protein	146											0				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		CTAGGATCTTCGTTTTTTCTT	0.323													T	213181756	T	T	213181756	2	4	263	1	0	0	0	0	0	0	0	1	609	871	31	2		2	ANGEL2	1	213181756	Silent	SNP	C	TCGA-76-4932-01A-01D-1486-08	59114308	213181756	36068865	7	18845											
OBSCN	84033	broad.mit.edu	37	chr1	228557749	228557749	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccatggctgcccacctcagcGaagacgccaaagacttcatc	8	16	2	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr1:228557749G>A	uc009xez.1	+	91	20118	c.20074G>A	c.(20074-20076)GAA>AAA	p.E6692K	OBSCN_uc001hsr.1_Missense_Mutation_p.E1321K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6692	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCACCTCAGCGAAGACGCCAA	0.667													A	228557749	A	A	228557749	3	1	263	1	0	0	0	0	1	0	0	0	10812	1059	37	2	21642	2	OBSCN	1	228557749	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	15375993	228557749	20692872	8	18846											
SIPA1L2	57568	broad.mit.edu	37	chr1	232649623	232649623	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttcccatagaagaatttgCggtaataataggccccaagg	9	9	0	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr1:232649623C>T	uc001hvg.2	-	1	1621	c.1463G>A	c.(1462-1464)CGC>CAC	p.R488H		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	488					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GAAGAATTTGCGGTAATAATA	0.453													T	232649623	T	T	232649623	3	4	263	1	0	0	0	0	1	0	0	0	14330	768	27	1	3789	1	SIPA1L2	1	232649623	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	4091874	232649623	16600998	9	18847											
MFSD9	84804	broad.mit.edu	37	chr2	103335600	103335600	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccaacagcacatgggtctttCgcaatggcaggcccttctct	9	14	2	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr2:103335600C>T	uc002tcb.2	-	6	772	c.704G>A	c.(703-705)CGA>CAA	p.R235Q	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	235					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						ATGGGTCTTTCGCAATGGCAG	0.567													T	103335600	T	T	103335600	3	4	263	1	0	0	0	0	1	0	0	0	9539	884	31	2	724	2	MFSD9	2	103335600	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08		103335600	139863773	10	18848											
SLC5A7	60482	broad.mit.edu	37	chr2	108626880	108626880	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaccaacacctatggggccGtggcaggttatgtttctggc	13	10	1	0	rs148535388	byFrequency	TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr2:108626880G>A	uc002tdv.2	+	9	1582	c.1306G>A	c.(1306-1308)GTG>ATG	p.V436M	SLC5A7_uc010ywm.1_Missense_Mutation_p.V189M|SLC5A7_uc010fjj.2_Missense_Mutation_p.V436M|SLC5A7_uc010ywn.1_Missense_Mutation_p.V323M	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	436	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CTATGGGGCCGTGGCAGGTTA	0.488													A	108626880	A	A	108626880	3	1	263	1	0	0	0	0	1	0	0	0	14670	1145	40	1	1336	1	SLC5A7	2	108626880	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	5291280	108626880	134572493	11	18849											
ZRANB3	84083	broad.mit.edu	37	chr2	135958008	135958008	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tccttagcttgtctggcagtTctctaaaagttaaaaaatat	6	7	2	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr2:135958008T>C	uc002tum.2	-	21	3261	c.3144A>G	c.(3142-3144)AGA>AGG	p.R1048R	ZRANB3_uc002tuk.2_Silent_p.R591R|ZRANB3_uc002tul.2_Silent_p.R1046R	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	1048						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		GTCTGGCAGTTCTCTAAAAGT	0.363													C	135958008	C	C	135958008	2	2	263	1	0	0	0	0	0	0	0	1	18221	1780	62	4		4	ZRANB3	2	135958008	Silent	SNP	T	TCGA-76-4932-01A-01D-1486-08	27331128	135958008	107241365	12	18850											
CWC22	57703	broad.mit.edu	37	chr2	180810270	180810270	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctccaatttgaaccacttgaAttttgatctctgtgtttttc	5	9	1	3			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr2:180810270A>G	uc010frh.1	-	20	2613	c.2313T>C	c.(2311-2313)AAT>AAC	p.N771N	CWC22_uc002uno.2_Silent_p.N293N|CWC22_uc002unp.2_Silent_p.N771N	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	771						catalytic step 2 spliceosome	protein binding|RNA binding				0						AACCACTTGAATTTTGATCTC	0.378													G	180810270	G	G	180810270	2	3	263	1	0	0	0	0	0	0	0	1	4068	98	4	4		4	CWC22	2	180810270	Silent	SNP	A	TCGA-76-4932-01A-01D-1486-08	44852262	180810270	62389103	13	18851											
FAM134A	79137	broad.mit.edu	37	chr2	220046109	220046109	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agagcgtcaggggaagaatgCacccccaggaggtgatgagc	16	9	1	4			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr2:220046109C>T	uc002vjw.3	+	7	939	c.803C>T	c.(802-804)GCA>GTA	p.A268V	FAM134A_uc010fwc.2_Missense_Mutation_p.A61V|FAM134A_uc002vjx.2_Missense_Mutation_p.A61V	NM_024293	NP_077269	Q8NC44	F134A_HUMAN	hypothetical protein LOC79137	268						endoplasmic reticulum|integral to membrane				ovary(1)|central_nervous_system(1)	2		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGAAGAATGCACCCCCAGGA	0.547													T	220046109	T	T	220046109	3	4	263	1	0	0	0	0	1	0	0	0	5445	710	25	3	829	3	FAM134A	2	220046109	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	39235839	220046109	23153264	14	18852											
PAX3	5077	broad.mit.edu	37	chr2	223161799	223161799	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggacacgcgcagctggcgCgagatgacgcagggccggat	18	11	0	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr2:223161799C>T	uc010fwo.2	-	2	585	c.219G>A	c.(217-219)TCG>TCA	p.S73S	PAX3_uc002vmt.1_Silent_p.S73S|PAX3_uc002vmy.1_Silent_p.S73S|PAX3_uc002vmv.1_Silent_p.S73S|PAX3_uc002vmw.1_Silent_p.S73S|PAX3_uc002vmx.1_Silent_p.S73S|PAX3_uc002vmz.1_Silent_p.S73S|PAX3_uc002vna.1_Silent_p.S73S|CCDC140_uc002vnb.1_5'Flank	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	73	Paired.		S -> L (in WS1).		apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAGCTGGCGCGAGATGACGC	0.647			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						T	223161799	T	T	223161799	2	4	263	1	0	0	0	0	0	0	0	1	11480	755	27	1		1	PAX3	2	223161799	Silent	SNP	C	TCGA-76-4932-01A-01D-1486-08	3115690	223161799	20037574	15	18853											
COL4A4	1286	broad.mit.edu	37	chr2	227922184	227922184	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggatacccagggagtcccGgttgccctggtatccctgga	13	13	0	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr2:227922184G>A	uc010zlt.1	-	29	3170	c.2516C>T	c.(2515-2517)CCG>CTG	p.P839L		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	839	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		AGGGAGTCCCGGTTGCCCTGG	0.433													A	227922184	A	A	227922184	3	1	263	1	0	0	0	0	1	0	0	0	3693	1116	39	2	2636	2	COL4A4	2	227922184	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	4760385	227922184	15277189	16	18854											
CNTN4	152330	broad.mit.edu	37	chr3	2787313	2787313	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taaaacccaagatgctggaaCgtaccagtgcacagcgacaa	9	11	0	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr3:2787313C>T	uc003bpc.2	+	5	511	c.290C>T	c.(289-291)ACG>ATG	p.T97M	CNTN4_uc003bpb.1_Translation_Start_Site|CNTN4_uc003bpd.1_Missense_Mutation_p.T97M	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	97	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GATGCTGGAACGTACCAGTGC	0.408													T	2787313	T	T	2787313	3	4	263	1	0	0	0	0	1	0	0	0	3643	536	19	1	300	1	CNTN4	3	2787313	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08		2787313	195235117	17	18855											
CHST13	166012	broad.mit.edu	37	chr3	126260762	126260762	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgcaccaactggaagcgcGtgctgctggcgctgagcggc	15	14	0	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr3:126260762G>A	uc003eja.2	+	3	367	c.367G>A	c.(367-369)GTG>ATG	p.V123M		NM_152889	NP_690849	Q8NET6	CHSTD_HUMAN	carbohydrate sulfotransferase 13	123	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.151)		CTGGAAGCGCGTGCTGCTGGC	0.716													A	126260762	A	A	126260762	3	1	263	1	0	0	0	0	1	0	0	0	3401	1145	40	1	377	1	CHST13	3	126260762	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	123473449	126260762	71761668	18	18856											
ECE2	9718	broad.mit.edu	37	chr3	184009860	184009860	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tggcccgcaggtgtggtgctCggtccgcacaccagagagct	15	13	0	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr3:184009860C>T	uc003fni.3	+	19	2524	c.2486C>T	c.(2485-2487)TCG>TTG	p.S829L	ECE2_uc003fnl.3_Missense_Mutation_p.S757L|ECE2_uc003fnm.3_Missense_Mutation_p.S711L|ECE2_uc003fnk.3_Missense_Mutation_p.S682L	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	829	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GTGTGGTGCTCGGTCCGCACA	0.647													T	184009860	T	T	184009860	3	4	263	1	0	0	0	0	1	0	0	0	4890	893	31	2	3124	2	ECE2	3	184009860	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	57749098	184009860	14012570	19	18857											
PDE6B	5158	broad.mit.edu	37	chr4	619767	619767	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagcgtgcagccggacagcGtcctggaggactgcctggtg	16	12	1	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr4:619767G>A	uc003gap.2	+	1	405	c.352G>A	c.(352-354)GTC>ATC	p.V118I	PDE6B_uc003gao.3_Missense_Mutation_p.V118I	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	118	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						GCCGGACAGCGTCCTGGAGGA	0.657													A	619767	A	A	619767	3	1	263	1	0	0	0	0	1	0	0	0	11646	1145	40	1	354	1	PDE6B	4	619767	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08		619767	190534509	20	18858											
AASDH	132949	broad.mit.edu	37	chr4	57237647	57237647	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gtcactctatgatgggaaaaGagaacgctggctaattttga	11	6	2	3			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr4:57237647G>C	uc003hbn.2	-	5	984	c.831C>G	c.(829-831)CTC>CTG	p.L277L	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Silent_p.L124L|AASDH_uc003hbo.2_Silent_p.L177L|AASDH_uc011cab.1_5'UTR|AASDH_uc010ihc.2_Silent_p.L277L|AASDH_uc003hbp.2_Silent_p.L277L	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	277					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				GATGGGAAAAGAGAACGCTGG	0.353													C	57237647	C	C	57237647	2	2	263	1	0	0	0	0	0	0	0	1	22	929	33	5		5	AASDH	4	57237647	Silent	SNP	G	TCGA-76-4932-01A-01D-1486-08	56617880	57237647	133916629	21	18859											
FRG1	2483	broad.mit.edu	37	chr4	190876274	190876274	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggcgttcagatgcaattggaCcaagagaacaatgggaacca	12	8	1	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr4:190876274C>A	uc003izs.2	+	5	591	c.400C>A	c.(400-402)CCA>ACA	p.P134T		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	134					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TGCAATTGGACCAAGAGAACA	0.358													A	190876274	A	A	190876274	3	1	263	1	0	0	0	0	1	0	0	0	6046	507	18	5	418	5	FRG1	4	190876274	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	133638627	190876274	278002	22	18860											
PRDM9	56979	broad.mit.edu	37	chr5	23527430	23527430	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	accagaggacacacacagggGagaagccctatgtctgcagg	13	11	1	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr5:23527430G>T	uc003jgo.2	+	11	2415	c.2233G>T	c.(2233-2235)GAG>TAG	p.E745*		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	745					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ACACACAGGGGAGAAGCCCTA	0.582										HNSCC(3;0.000094)			T	23527430	T	T	23527430	4	4	263	1	0	0	0	0	0	1	0	0	12463	1175	41	5	2271	5	PRDM9	5	23527430	Nonsense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08		23527430	157387830	23	18861											
TNFAIP8	25816	broad.mit.edu	37	chr5	118728680	118728680	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tacacccaaaacaagaaggaGgcagagaagatcatcaagaa	9	8	2	4			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr5:118728680G>T	uc003ksh.2	+	3	889	c.201G>T	c.(199-201)GAG>GAT	p.E67D	TNFAIP8_uc003ksf.1_Intron|TNFAIP8_uc003ksg.2_Missense_Mutation_p.E57D|TNFAIP8_uc011cwf.1_Missense_Mutation_p.E61D|TNFAIP8_uc003ksi.2_Missense_Mutation_p.E67D	NM_014350	NP_055165	O95379	TFIP8_HUMAN	tumor necrosis factor, alpha-induced protein 8	67	Potential.				anti-apoptosis|apoptosis|negative regulation of anti-apoptosis	cytoplasm	caspase inhibitor activity|protein binding			ovary(1)	1		all_cancers(142;0.0317)|Prostate(80;0.111)|Breast(839;0.231)		Epithelial(69;4.63e-83)|OV - Ovarian serous cystadenocarcinoma(64;1.39e-82)|all cancers(49;4.88e-75)|GBM - Glioblastoma multiforme(465;0.00338)|BRCA - Breast invasive adenocarcinoma(61;0.0148)|COAD - Colon adenocarcinoma(49;0.0829)		ACAAGAAGGAGGCAGAGAAGA	0.443													T	118728680	T	T	118728680	3	4	263	1	0	0	0	0	1	0	0	0	16273	991	35	5	212	5	TNFAIP8	5	118728680	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	95201250	118728680	62186580	24	18862											
PCDHA1	56147	broad.mit.edu	37	chr5	140167119	140167119	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttggacagcgccctggatcGcgagagcctgtcggtctatg	15	11	1	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr5:140167119G>A	uc003lhb.2	+	1	1244	c.1244G>A	c.(1243-1245)CGC>CAC	p.R415H	PCDHA1_uc003lha.2_Missense_Mutation_p.R415H|PCDHA1_uc003lgz.2_Missense_Mutation_p.R415H	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	415	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCTGGATCGCGAGAGCCTG	0.637													A	140167119	A	A	140167119	3	1	263	1	0	0	0	0	1	0	0	0	11519	1087	38	1	1246	1	PCDHA1	5	140167119	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	21438439	140167119	40748141	25	18863											
PCDHGA2	56113	broad.mit.edu	37	chr5	140719024	140719024	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aatgcgcatgatgcagacgtAggtgagaacgcccttcagaa	12	9	1	4			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr5:140719024A>G	uc003ljk.1	+	1	671	c.486A>G	c.(484-486)GTA>GTG	p.V162V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.V162V	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	162	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCAGACGTAGGTGAGAACG	0.522													G	140719024	G	G	140719024	2	3	263	1	0	0	0	0	0	0	0	1	11554	407	15	4		4	PCDHGA2	5	140719024	Silent	SNP	A	TCGA-76-4932-01A-01D-1486-08	551905	140719024	40196236	26	18864											
DEFB110	245913	broad.mit.edu	37	chr6	49976857	49976857	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcttttccagagtttatacGcagcactgacttctccattt	5	11	2	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr6:49976857G>A	uc011dwr.1	-	2	229	c.183C>T	c.(181-183)TGC>TGT	p.C61C		NM_001037728	NP_001032817	Q30KQ9	DB110_HUMAN	beta-defensin 110 isoform b	64					defense response to bacterium	extracellular region				ovary(1)	1	Lung NSC(77;0.042)					GAGTTTATACGCAGCACTGAC	0.343													A	49976857	A	A	49976857	2	1	263	1	0	0	0	0	0	0	0	1	4400	1079	38	1		1	DEFB110	6	49976857	Silent	SNP	G	TCGA-76-4932-01A-01D-1486-08		49976857	121138210	27	18865											
SFRS13B	135295	broad.mit.edu	37	chr6	89808574	89808574	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagagccaaaattccttcttGgagttcttgactgccttgct	8	10	2	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr6:89808574G>A	uc003pmy.3	-	5	703	c.509C>T	c.(508-510)CCA>CTA	p.P170L		NM_080743	NP_542781	Q8WXF0	SRS12_HUMAN	serine-arginine repressor protein	170	Arg/Ser-rich (RS domain).				assembly of spliceosomal tri-snRNP|cytoplasmic transport|negative regulation of nuclear mRNA splicing, via spliceosome|nuclear mRNA 5'-splice site recognition|regulation of alternative nuclear mRNA splicing, via spliceosome	nucleoplasm	nucleotide binding|RNA binding|RS domain binding|unfolded protein binding				0						ATTCCTTCTTGGAGTTCTTGA	0.453													A	89808574	A	A	89808574	3	1	263	1	0	0	0	0	1	0	0	0	14169	1348	47	3	280	3	SFRS13B	6	89808574	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	39831717	89808574	81306493	28	18866											
KIAA1244	57221	broad.mit.edu	37	chr6	138599742	138599742	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaagcggccgaccctggcGccaggcgtgatggtgagtgt	18	10	0	2	rs111857517	by1000genomes	TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr6:138599742G>A	uc003qhu.2	+	13	2283	c.2283G>A	c.(2281-2283)GCG>GCA	p.A761A		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	761	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CGACCCTGGCGCCAGGCGTGA	0.612													A	138599742	A	A	138599742	2	1	263	1	0	0	0	0	0	0	0	1	8217	1074	38	1		1	KIAA1244	6	138599742	Silent	SNP	G	TCGA-76-4932-01A-01D-1486-08	48791168	138599742	32515325	29	18867											
IGFBP3	3486	broad.mit.edu	37	chr7	45956872	45956872	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatctgtgctctgagactcGtagtcaactttgtagcgctg	11	9	3	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr7:45956872G>A	uc003tns.2	-	2	702	c.570C>T	c.(568-570)TAC>TAT	p.Y190Y	IGFBP3_uc003tnq.2_RNA|IGFBP3_uc003tnr.2_Silent_p.Y196Y|IGFBP3_uc003tnt.2_Silent_p.Y93Y	NM_000598	NP_000589	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	190					negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(2)|lung(1)	3					Mecasermin(DB01277)	TCTGAGACTCGTAGTCAACTT	0.502											OREG0018049	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	45956872	A	A	45956872	2	1	263	1	0	0	0	0	0	0	0	1	7580	1140	40	1		1	IGFBP3	7	45956872	Silent	SNP	G	TCGA-76-4932-01A-01D-1486-08		45956872	113181791	30	18868											
TFPI2	7980	broad.mit.edu	37	chr7	93519456	93519456	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcagggcacttactttctatCctccagcaagcatcgtcgca	8	14	1	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr7:93519456C>T	uc003umy.1	-	2	339	c.264G>A	c.(262-264)AGG>AGA	p.R88R	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_Silent_p.R88R|TFPI2_uc003una.1_Silent_p.R77R|TFPI2_uc003unb.1_Silent_p.R88R|TFPI2_uc010lfg.1_Intron	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	88					blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			TACTTTCTATCCTCCAGCAAG	0.617													T	93519456	T	T	93519456	2	4	263	1	0	0	0	0	0	0	0	1	15806	854	30	3		3	TFPI2	7	93519456	Silent	SNP	C	TCGA-76-4932-01A-01D-1486-08	47562584	93519456	65619207	31	18869											
PEG10	23089	broad.mit.edu	37	chr7	94293373	94293373	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaggcgagaggttgccaaaCgcaagatcagacgcctgcgc	14	11	1	4			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr7:94293373C>T	uc011kie.1	+	2	950	c.733C>T	c.(733-735)CGC>TGC	p.R245C		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	169	Necessary for interaction with ALK1.				apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			GGTTGCCAAACGCAAGATCAG	0.537													T	94293373	T	T	94293373	3	4	263	1	0	0	0	0	1	0	0	0	11719	536	19	1	739	1	PEG10	7	94293373	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	773917	94293373	64845290	32	18870											
ZYX	7791	broad.mit.edu	37	chr7	143080252	143080252	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagtcctggagccccaggtgGatctgggtcacaaccaaatc	11	13	2	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr7:143080252G>A	uc003wcw.2	+	5	1015	c.860G>A	c.(859-861)GGA>GAA	p.G287E	ZYX_uc011ktd.1_Missense_Mutation_p.G130E|ZYX_uc003wcx.2_Missense_Mutation_p.G287E|ZYX_uc011kte.1_Missense_Mutation_p.G256E|ZYX_uc011ktf.1_Missense_Mutation_p.G130E	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	287					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					GCCCCAGGTGGATCTGGGTCA	0.577													A	143080252	A	A	143080252	3	1	263	1	0	0	0	0	1	0	0	0	18251	1174	41	3	874	3	ZYX	7	143080252	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	48786879	143080252	16058411	33	18871											
EPHA1	2041	broad.mit.edu	37	chr7	143095154	143095154	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctagaaccatctggtaccGttcttcatcctgtgggttgg	10	10	4	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr7:143095154G>A	uc003wcz.2	-	8	1561	c.1474C>T	c.(1474-1476)CGG>TGG	p.R492W		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	492	Extracellular (Potential).|Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				ATCTGGTACCGTTCTTCATCC	0.572													A	143095154	A	A	143095154	3	1	263	1	0	0	0	0	1	0	0	0	5165	1144	40	1	1500	1	EPHA1	7	143095154	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	14902	143095154	16043509	34	18872											
ASB10	136371	broad.mit.edu	37	chr7	150878355	150878355	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcggtgatggactggcagcGgacgtcacaggcagccagca	15	11	1	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr7:150878355G>A	uc003wjm.1	-	3	1036	c.910C>T	c.(910-912)CGC>TGC	p.R304C	ASB10_uc003wjl.1_Missense_Mutation_p.R304C|ASB10_uc003wjn.1_Missense_Mutation_p.R244C	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	259	ANK 5.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GACTGGCAGCGGACGTCACAG	0.647													A	150878355	A	A	150878355	3	1	263	1	0	0	0	0	1	0	0	0	1014	1116	39	2	640	2	ASB10	7	150878355	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	7783201	150878355	8260308	35	18873											
DOCK5	80005	broad.mit.edu	37	chr8	25250313	25250313	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttttccttcttgccaccagaCgatgtggattgaacggacca	9	11	1	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr8:25250313C>T	uc003xeg.2	+	44	4579	c.4442C>T	c.(4441-4443)ACG>ATG	p.T1481M	PPP2R2A_uc003xek.2_Intron|DOCK5_uc003xei.2_Missense_Mutation_p.T1051M|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1481	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TGCCACCAGACGATGTGGATT	0.428													T	25250313	T	T	25250313	3	4	263	1	0	0	0	0	1	0	0	0	4690	550	19	1	4616	1	DOCK5	8	25250313	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08		25250313	121113709	36	18874											
CPSF1	29894	broad.mit.edu	37	chr8	145622709	145622709	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggcaccacctacctccatgGtgccattctcccgcaccagc	8	19	1	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr8:145622709G>A	uc003zcj.2	-	22	2453	c.2378C>T	c.(2377-2379)ACC>ATC	p.T793I		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	793					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			TACCTCCATGGTGCCATTCTC	0.672													A	145622709	A	A	145622709	3	1	263	1	0	0	0	0	1	0	0	0	3824	1261	44	3	2021	3	CPSF1	8	145622709	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	120372396	145622709	741313	37	18875											
NPR2	4882	broad.mit.edu	37	chr9	35808664	35808664	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catgaccagctgaggctacgCataggggtccatactggtaa	12	10	0	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr9:35808664C>T	uc003zyd.2	+	19	2871	c.2871C>T	c.(2869-2871)CGC>CGT	p.R957R	NPR2_uc010mlb.2_Silent_p.R933R|SPAG8_uc003zye.2_Intron	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	957	Guanylate cyclase.|Cytoplasmic (Potential).		R -> C (in AMDM).		intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	TGAGGCTACGCATAGGGGTCC	0.542													T	35808664	T	T	35808664	2	4	263	1	0	0	0	0	0	0	0	1	10595	697	25	3		3	NPR2	9	35808664	Silent	SNP	C	TCGA-76-4932-01A-01D-1486-08		35808664	105404767	38	18876											
OR4C16	219428	broad.mit.edu	37	chr11	55340484	55340484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagaatacagaagtgaaaaGtgccatgaggaagctttgga	13	4	0	4			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr11:55340484G>A	uc010rih.1	+	1	881	c.881G>A	c.(880-882)AGT>AAT	p.S294N		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GAAGTGAAAAGTGCCATGAGG	0.368													A	55340484	A	A	55340484	3	1	263	1	0	0	0	0	1	0	0	0	11049	1029	36	3	883	3	OR4C16	11	55340484	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08		55340484	79666032	39	18877											
OR8H1	219469	broad.mit.edu	37	chr11	56058035	56058035	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgacgaactacatttgagtcGcagaaatgcagtctgctcat	9	9	2	3			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr11:56058035G>A	uc010rje.1	-	1	504	c.504C>T	c.(502-504)TGC>TGT	p.C168C		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					CATTTGAGTCGCAGAAATGCA	0.433													A	56058035	A	A	56058035	2	1	263	1	0	0	0	0	0	0	0	1	11237	1079	38	1		1	OR8H1	11	56058035	Silent	SNP	G	TCGA-76-4932-01A-01D-1486-08	717551	56058035	78948481	40	18878											
OSBP	5007	broad.mit.edu	37	chr11	59368009	59368009	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttcttttccaatgcagttcTtcatgatgctccataaattg	6	9	3	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr11:59368009T>C	uc001noc.1	-	7	1751	c.1271A>G	c.(1270-1272)AAG>AGG	p.K424R	OSBP_uc009ymr.1_RNA	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	424	Sterol binding (By similarity).				lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		AATGCAGTTCTTCATGATGCT	0.468													C	59368009	C	C	59368009	3	2	263	1	0	0	0	0	1	0	0	0	11273	1609	56	4	1184	4	OSBP	11	59368009	Missense_Mutation	SNP	T	TCGA-76-4932-01A-01D-1486-08	3309974	59368009	75638507	41	18879											
ACTN3	89	broad.mit.edu	37	chr11	66328735	66328737	+	In_Frame_Del	DEL	AGG	-	-													cagctgtgaccagacactgcAggaggagctggcacggcagc							TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr11:66328735_66328737delAGG	uc001oio.1	+	17	1916_1918	c.1898_1900delAGG	c.(1897-1902)CAGGAG>CAG	p.E635del	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	635					focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						CAGACACTGCAGGAGGAGCTGGC	0.621													-	66328737	-	-	66328735	7	5	263	1	0	1	0	1	0	0	0	0	206	188	7	0	1960	0	ACTN3	11	66328735	In_Frame_Del	DEL	AGG	TCGA-76-4932-01A-01D-1486-08	6960726	66328735	68677781	42	18880											
NAALAD2	10003	broad.mit.edu	37	chr11	89882229	89882229	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggctatgagaatgttacaaAtattgtgccaccatataatg	8	6	0	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr11:89882229A>G	uc001pdf.3	+	4	546	c.437A>G	c.(436-438)AAT>AGT	p.N146S	NAALAD2_uc009yvx.2_Missense_Mutation_p.N146S|NAALAD2_uc009yvy.2_Missense_Mutation_p.N146S|NAALAD2_uc001pdd.2_Missense_Mutation_p.N146S|NAALAD2_uc001pde.2_Missense_Mutation_p.N146S	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	146	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				AATGTTACAAATATTGTGCCA	0.328													G	89882229	G	G	89882229	3	3	263	1	0	0	0	0	1	0	0	0	10128	101	4	4	451	4	NAALAD2	11	89882229	Missense_Mutation	SNP	A	TCGA-76-4932-01A-01D-1486-08	23553494	89882229	45124287	43	18881											
CLSTN3	9746	broad.mit.edu	37	chr12	7310162	7310162	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtcgtcctgggcctggtgCgcatccattcccttcaccgc	11	16	1	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr12:7310162C>T	uc001qsr.2	+	17	2883	c.2605C>T	c.(2605-2607)CGC>TGC	p.R869C	CLSTN3_uc001qss.2_Missense_Mutation_p.R881C|CLSTN3_uc001qst.2_Missense_Mutation_p.R277C	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	869	Cytoplasmic (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						GGGCCTGGTGCGCATCCATTC	0.657													T	7310162	T	T	7310162	3	4	263	1	0	0	0	0	1	0	0	0	3563	768	27	1	2671	1	CLSTN3	12	7310162	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08		7310162	126541733	44	18882											
PPFIBP1	8496	broad.mit.edu	37	chr12	27841316	27841316	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtggacttggcagaatatgCgcccaatctcagaggcagtg	13	10	1	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr12:27841316C>T	uc001ric.1	+	25	2851	c.2474C>T	c.(2473-2475)GCG>GTG	p.A825V	PPFIBP1_uc010sjr.1_Missense_Mutation_p.A656V|PPFIBP1_uc001rib.1_Missense_Mutation_p.A819V|PPFIBP1_uc001ria.2_Missense_Mutation_p.A794V|PPFIBP1_uc001rid.1_Missense_Mutation_p.A672V|PPFIBP1_uc001rif.1_Missense_Mutation_p.A332V	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	825	SAM 3.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					GCAGAATATGCGCCCAATCTC	0.473													T	27841316	T	T	27841316	3	4	263	1	0	0	0	0	1	0	0	0	12313	768	27	1	2592	1	PPFIBP1	12	27841316	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	20531154	27841316	106010579	45	18883											
SLC38A4	55089	broad.mit.edu	37	chr12	47163175	47163175	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgtatccagctgaagggtcGtttgggaaataacagtgtga	13	6	0	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr12:47163175G>A	uc001rpi.2	-	15	1735	c.1336C>T	c.(1336-1338)CGA>TGA	p.R446*	SLC38A4_uc001rpj.2_Nonsense_Mutation_p.R446*	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	446	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					CTGAAGGGTCGTTTGGGAAAT	0.363													A	47163175	A	A	47163175	4	1	263	1	0	0	0	0	0	1	0	0	14606	1153	40	1	319	1	SLC38A4	12	47163175	Nonsense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	19321859	47163175	86688720	46	18884											
DNAJC22	79962	broad.mit.edu	37	chr12	49745175	49745175	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agctagtgaaggtctggcacCcagaccacaacctggaccag	11	13	1	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr12:49745175C>T	uc001rua.2	+	3	1317	c.916C>T	c.(916-918)CCA>TCA	p.P306S	DNAJC22_uc001rub.2_Missense_Mutation_p.P306S	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	306	J.				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						GGTCTGGCACCCAGACCACAA	0.522													T	49745175	T	T	49745175	3	4	263	1	0	0	0	0	1	0	0	0	4641	623	22	3	922	3	DNAJC22	12	49745175	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	2582000	49745175	84106720	47	18885											
TARBP2	6895	broad.mit.edu	37	chr12	53895818	53895818	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatagagcaaatgctggccGccaacccaggcaagaccccg	11	14	0	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr12:53895818G>A	uc001sdo.2	+	2	561	c.73G>A	c.(73-75)GCC>ACC	p.A25T	MAP3K12_uc001sdm.1_5'Flank|MAP3K12_uc001sdn.1_5'Flank|TARBP2_uc009znb.2_Missense_Mutation_p.A25T|TARBP2_uc001sdp.2_Missense_Mutation_p.A4T|TARBP2_uc001sdq.2_Intron|TARBP2_uc001sdr.2_5'UTR|TARBP2_uc001sds.2_Missense_Mutation_p.A25T|TARBP2_uc001sdt.2_Missense_Mutation_p.A4T|TARBP2_uc001sdu.2_5'UTR|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	25	Sufficient for interaction with PRKRA.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						AATGCTGGCCGCCAACCCAGG	0.592													A	53895818	A	A	53895818	3	1	263	1	0	0	0	0	1	0	0	0	15553	1087	38	1	79	1	TARBP2	12	53895818	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	4150643	53895818	79956077	48	18886											
CCDC63	160762	broad.mit.edu	37	chr12	111322003	111322003	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctcggttcacgtatgtcacGgagctcaacaacgacatgga	11	11	3	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr12:111322003G>A	uc001trv.1	+	8	1218	c.1023G>A	c.(1021-1023)ACG>ACA	p.T341T	CCDC63_uc010sye.1_Silent_p.T301T|CCDC63_uc001trw.1_Silent_p.T256T	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	341	Potential.									skin(6)|ovary(1)|pancreas(1)	8						CGTATGTCACGGAGCTCAACA	0.552													A	111322003	A	A	111322003	2	1	263	1	0	0	0	0	0	0	0	1	2834	1103	39	2		2	CCDC63	12	111322003	Silent	SNP	G	TCGA-76-4932-01A-01D-1486-08	57426185	111322003	22529892	49	18887											
OASL	8638	broad.mit.edu	37	chr12	121469372	121469372	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gaccaccgcaggccttgatcAggctcacatagacctcaggg	11	14	3	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr12:121469372A>G	uc001tzj.1	-	3	536	c.530T>C	c.(529-531)CTG>CCG	p.L177P	OASL_uc001tzk.1_Missense_Mutation_p.L177P	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	177					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGCCTTGATCAGGCTCACATA	0.552													G	121469372	G	G	121469372	3	3	263	1	0	0	0	0	1	0	0	0	10802	188	7	4	1030	4	OASL	12	121469372	Missense_Mutation	SNP	A	TCGA-76-4932-01A-01D-1486-08	10147369	121469372	12382523	50	18888											
RIMBP2	23504	broad.mit.edu	37	chr12	130934752	130934752	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccgcacttacctatagcGggcaacacagaggtggacct	13	12	0	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr12:130934752G>A	uc001uil.2	-	6	687	c.523C>T	c.(523-525)CGC>TGC	p.R175C	RIMBP2_uc001uim.2_Missense_Mutation_p.R83C	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	175	SH3 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TACCTATAGCGGGCAACACAG	0.552													A	130934752	A	A	130934752	3	1	263	1	0	0	0	0	1	0	0	0	13363	1116	39	2	2691	2	RIMBP2	12	130934752	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	9465380	130934752	2917143	51	18889											
USPL1	10208	broad.mit.edu	37	chr13	31232152	31232152	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtaatgaaaagcttattcaAgaccaatttgtggacataag	8	5	1	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr13:31232152A>G	uc001utc.2	+	9	2370	c.1938A>G	c.(1936-1938)CAA>CAG	p.Q646Q	USPL1_uc001utd.2_Silent_p.Q317Q|USPL1_uc001ute.1_Silent_p.Q317Q	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	646					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AGCTTATTCAAGACCAATTTG	0.343													G	31232152	G	G	31232152	2	3	263	1	0	0	0	0	0	0	0	1	17089	69	3	4		4	USPL1	13	31232152	Silent	SNP	A	TCGA-76-4932-01A-01D-1486-08		31232152	83937726	52	18890											
THSD1	55901	broad.mit.edu	37	chr13	52951899	52951899	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atccccaaggtctggtttccTcaagggctgccccaaagtgt	10	13	2	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr13:52951899T>C	uc001vgo.2	-	5	2751	c.2206A>G	c.(2206-2208)AGG>GGG	p.R736G	THSD1_uc001vgp.2_Missense_Mutation_p.R683G|THSD1_uc010tgz.1_Missense_Mutation_p.R357G|THSD1_uc010aea.2_Missense_Mutation_p.R197G	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	736	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		TCTGGTTTCCTCAAGGGCTGC	0.552													C	52951899	C	C	52951899	3	2	263	1	0	0	0	0	1	0	0	0	15874	1550	54	4	356	4	THSD1	13	52951899	Missense_Mutation	SNP	T	TCGA-76-4932-01A-01D-1486-08	21719747	52951899	62217979	53	18891											
EDDM3A	10876	broad.mit.edu	37	chr14	21216002	21216002	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	caatgagaaggggagcgaccGatatagaaatgcatatgtat	12	5	0	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr14:21216002G>A	uc001vyb.2	+	2	330	c.263G>A	c.(262-264)CGA>CAA	p.R88Q	EDDM3A_uc001vyc.2_Missense_Mutation_p.R88Q	NM_006683	NP_006674	Q14507	EP3A_HUMAN	human epididymis-specific 3 alpha precursor	88					sperm displacement	extracellular space					0						GGGAGCGACCGATATAGAAAT	0.453													A	21216002	A	A	21216002	3	1	263	1	0	0	0	0	1	0	0	0	4909	1058	37	2	265	2	EDDM3A	14	21216002	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08		21216002	86133538	54	18892											
MKRN3	7681	broad.mit.edu	37	chr15	23811039	23811039	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggaccttcccgtctgtgagcCctccggggaatctgctgctc	12	15	2	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr15:23811039C>A	uc001ywh.3	+	1	586	c.110C>A	c.(109-111)CCC>CAC	p.P37H	MKRN3_uc001ywi.2_Missense_Mutation_p.P37H|MKRN3_uc010ayi.1_Missense_Mutation_p.P37H	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	37						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GTCTGTGAGCCCTCCGGGGAA	0.687													A	23811039	A	A	23811039	3	1	263	1	0	0	0	0	1	0	0	0	9608	623	22	5	112	5	MKRN3	15	23811039	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08		23811039	78720353	55	18893											
TMOD2	29767	broad.mit.edu	37	chr15	52075020	52075020	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctcgcagcaatgaccctgtgGccattgtgagtaaaattctt	9	10	1	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr15:52075020G>C	uc002abk.2	+	7	948	c.727G>C	c.(727-729)GCC>CCC	p.A243P	TMOD2_uc002abl.3_Intron|TMOD2_uc010bfb.2_Missense_Mutation_p.A199P	NM_014548	NP_055363	Q9NZR1	TMOD2_HUMAN	neuronal tropomodulin isoform a	243					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(2)	2				all cancers(107;0.00435)		TGACCCTGTGGCCATTGTGAG	0.398													C	52075020	C	C	52075020	3	2	263	1	0	0	0	0	1	0	0	0	16231	1203	42	5	749	5	TMOD2	15	52075020	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	28263981	52075020	50456372	56	18894											
FSD2	123722	broad.mit.edu	37	chr15	83455346	83455346	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttccaatttgtacatgttttTgtgaatttcatcctatccaa	4	8	1	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr15:83455346T>C	uc002bjd.2	-	3	819	c.652A>G	c.(652-654)AAA>GAA	p.K218E	FSD2_uc010uol.1_Missense_Mutation_p.K218E|FSD2_uc010uom.1_Missense_Mutation_p.K218E	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	218	Potential.									central_nervous_system(1)	1						TACATGTTTTTGTGAATTTCA	0.363													C	83455346	C	C	83455346	3	2	263	1	0	0	0	0	1	0	0	0	6071	1821	63	4	1641	4	FSD2	15	83455346	Missense_Mutation	SNP	T	TCGA-76-4932-01A-01D-1486-08	31380326	83455346	19076046	57	18895											
PDE8A	5151	broad.mit.edu	37	chr15	85664158	85664158	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggccattttgtacaatgacaCtgctgtgctggagagccacc	11	11	0	2	rs144501404	byFrequency	TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr15:85664158C>G	uc002blh.2	+	18	2054	c.1865C>G	c.(1864-1866)ACT>AGT	p.T622S	PDE8A_uc002bli.2_Missense_Mutation_p.T576S|PDE8A_uc010bnc.2_Missense_Mutation_p.T375S|PDE8A_uc010bnd.2_Missense_Mutation_p.T375S|PDE8A_uc002blj.2_Missense_Mutation_p.T242S|PDE8A_uc002blk.2_Missense_Mutation_p.T242S|PDE8A_uc002bll.2_5'UTR	NM_002605	NP_002596	O60658	PDE8A_HUMAN	phosphodiesterase 8A isoform 1	622	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			TACAATGACACTGCTGTGCTG	0.483													G	85664158	G	G	85664158	3	3	263	1	0	0	0	0	1	0	0	0	11653	565	20	5	1935	5	PDE8A	15	85664158	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	2208812	85664158	16867234	58	18896											
PCSK6	5046	broad.mit.edu	37	chr15	101853660	101853660	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggctggcacacacttccagtCgtggaagtggaagtttttcg	13	9	0	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr15:101853660C>T	uc002bwy.2	-	21	2934	c.2620G>A	c.(2620-2622)GAC>AAC	p.D874N	PCSK6_uc010bpd.2_Missense_Mutation_p.D670N|PCSK6_uc010bpe.2_Missense_Mutation_p.D861N|PCSK6_uc002bxa.2_Missense_Mutation_p.D874N|PCSK6_uc002bxb.2_Missense_Mutation_p.D861N	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	874	CRM (Cys-rich motif).				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CACTTCCAGTCGTGGAAGTGG	0.567													T	101853660	T	T	101853660	3	4	263	1	0	0	0	0	1	0	0	0	11604	884	31	2	530	2	PCSK6	15	101853660	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	16189502	101853660	677732	59	18897											
SRCAP	10847	broad.mit.edu	37	chr16	30748891	30748894	+	Frame_Shift_Del	DEL	TCAT	-	-													gcctgtacccctccaccagcTcatacaccgcctccagccca							TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr16:30748891_30748894delTCAT	uc002dze.1	+	34	7915_7918	c.7530_7533delTCAT	c.(7528-7533)GCTCATfs	p.A2510fs	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Frame_Shift_Del_p.A2305fs	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2510_2511	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			ctccaccagctcatacaccgcctc	0.27													-	30748894	-	-	30748891	7	5	263	1	0	1	0	1	0	0	0	0	15134	1538	54	0	7656	0	SRCAP	16	30748891	Frame_Shift_Del	DEL	TCAT	TCGA-76-4932-01A-01D-1486-08		30748891	59605862	60	18898											
CNTNAP4	85445	broad.mit.edu	37	chr16	76461484	76461484	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatgcgaatcgaagtgttcGgatgtgcatacagtaagtgt	13	5	0	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr16:76461484G>A	uc002feu.1	+	6	911	c.526G>A	c.(526-528)GGA>AGA	p.G176R	CNTNAP4_uc002fev.1_Missense_Mutation_p.G88R|CNTNAP4_uc010chb.1_Missense_Mutation_p.G151R|CNTNAP4_uc002fex.1_Missense_Mutation_p.G179R|CNTNAP4_uc002few.2_Missense_Mutation_p.G151R	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	176	Extracellular (Potential).|F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CGAAGTGTTCGGATGTGCATA	0.398													A	76461484	A	A	76461484	3	1	263	1	0	0	0	0	1	0	0	0	3649	1117	39	2	553	2	CNTNAP4	16	76461484	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	45712593	76461484	13893269	61	18899											
ADAMTS18	170692	broad.mit.edu	37	chr16	77389861	77389861	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaatttcttgagatactggCggctgcaggaagaccatgaa	13	7	1	3			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr16:77389861C>T	uc002ffc.3	-	9	1855	c.1436G>A	c.(1435-1437)CGC>CAC	p.R479H	ADAMTS18_uc010chc.1_Missense_Mutation_p.R67H|ADAMTS18_uc002ffe.1_Missense_Mutation_p.R175H|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	479	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GAGATACTGGCGGCTGCAGGA	0.488													T	77389861	T	T	77389861	3	4	263	1	0	0	0	0	1	0	0	0	263	768	27	1	2289	1	ADAMTS18	16	77389861	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08	928377	77389861	12964892	62	18900											
KRT38	8687	broad.mit.edu	37	chr17	39593695	39593695	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccggtggtgctggctccaCaggtgggcccacaggtggtg	17	11	0	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr17:39593695C>T	uc002hwq.1	-	7	1763	c.1340G>A	c.(1339-1341)TGT>TAT	p.C447Y		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	447	Tail.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				GCTGGCTCCACAGGTGGGCCC	0.612													T	39593695	T	T	39593695	3	4	263	1	0	0	0	0	1	0	0	0	8475	478	17	3	34	3	KRT38	17	39593695	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08		39593695	41601515	63	18901											
DNM2	1785	broad.mit.edu	37	chr19	10887808	10887808	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcaggcctacggaccatcGgtgtcatcaccaagcttgac	9	13	3	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr19:10887808G>A	uc002mps.1	+	5	768	c.604G>A	c.(604-606)GGT>AGT	p.G202S	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Missense_Mutation_p.G202S|DNM2_uc002mpv.1_Missense_Mutation_p.G202S|DNM2_uc002mpu.1_Missense_Mutation_p.G202S|DNM2_uc010dxl.1_Missense_Mutation_p.G202S	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	202					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			ACGGACCATCGGTGTCATCAC	0.458													A	10887808	A	A	10887808	3	1	263	1	0	0	0	0	1	0	0	0	4672	1116	39	2	622	2	DNM2	19	10887808	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08		10887808	48241175	64	18902											
CILP2	148113	broad.mit.edu	37	chr19	19654993	19654993	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgatcctcgaggtgccggcGtgtaccacgaggtcaaggcc	14	12	1	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr19:19654993G>A	uc002nmv.3	+	8	1724	c.1639G>A	c.(1639-1641)GTG>ATG	p.V547M	CILP2_uc002nmw.3_Missense_Mutation_p.V553M	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	547						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						AGGTGCCGGCGTGTACCACGA	0.622													A	19654993	A	A	19654993	3	1	263	1	0	0	0	0	1	0	0	0	3430	1145	40	1	1669	1	CILP2	19	19654993	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	8767185	19654993	39473990	65	18903											
ZNF701	55762	broad.mit.edu	37	chr19	53085986	53085986	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgagagtggcaaagcctttaAtggtagctcactcttaaaaa	9	7	2	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr19:53085986A>G	uc002pzs.1	+	4	801	c.674A>G	c.(673-675)AAT>AGT	p.N225S	ZNF701_uc010ydn.1_Missense_Mutation_p.N291S	NM_018260	NP_060730	Q9NV72	ZN701_HUMAN	zinc finger protein 701	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		AAAGCCTTTAATGGTAGCTCA	0.368													G	53085986	G	G	53085986	3	3	263	1	0	0	0	0	1	0	0	0	18102	101	4	4	886	4	ZNF701	19	53085986	Missense_Mutation	SNP	A	TCGA-76-4932-01A-01D-1486-08	33430993	53085986	6042997	66	18904											
LILRB2	10288	broad.mit.edu	37	chr19	54782295	54782295	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggggcatcagctgctccCgccttggtcagaaggaaagt	14	10	2	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr19:54782295C>T	uc002qfb.2	-	7	1343	c.1077G>A	c.(1075-1077)GCG>GCA	p.A359A	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Silent_p.A359A|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Silent_p.A359A|LILRB2_uc010yet.1_Silent_p.A243A|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	359	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGCTGCTCCCGCCTTGGTCA	0.572													T	54782295	T	T	54782295	2	4	263	1	0	0	0	0	0	0	0	1	8791	639	23	2		2	LILRB2	19	54782295	Silent	SNP	C	TCGA-76-4932-01A-01D-1486-08	1696309	54782295	4346688	67	18905											
ZSCAN18	65982	broad.mit.edu	37	chr19	58601319	58601319	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtgccaccacccagggccGgaccttatcaggcaggatgc	12	15	1	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr19:58601319G>A	uc002qri.2	-	2	625	c.316C>T	c.(316-318)CGG>TGG	p.R106W	ZSCAN18_uc002qrj.3_Missense_Mutation_p.R106W|ZSCAN18_uc010yhs.1_Intron|ZSCAN18_uc002qrh.2_Missense_Mutation_p.R106W|ZSCAN18_uc010yht.1_Missense_Mutation_p.R162W|ZSCAN18_uc002qrk.1_Missense_Mutation_p.R106W|ZSCAN18_uc002qrl.2_Missense_Mutation_p.R106W	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	106	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		ACCCAGGGCCGGACCTTATCA	0.647													A	58601319	A	A	58601319	3	1	263	1	0	0	0	0	1	0	0	0	18227	1115	39	2	1240	2	ZSCAN18	19	58601319	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	3819024	58601319	527664	68	18906											
MATN4	8785	broad.mit.edu	37	chr20	43933173	43933173	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtactggattgccagtcccGtcatggtgccttgcgccaga	12	13	1	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr20:43933173G>A	uc002xnn.2	-	3	525	c.338C>T	c.(337-339)ACG>ATG	p.T113M	MATN4_uc002xno.2_Missense_Mutation_p.T113M|MATN4_uc002xnp.2_Missense_Mutation_p.T113M|MATN4_uc010zwr.1_Missense_Mutation_p.T61M|MATN4_uc002xnr.1_Missense_Mutation_p.T113M|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	113	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				TGCCAGTCCCGTCATGGTGCC	0.667													A	43933173	A	A	43933173	3	1	263	1	0	0	0	0	1	0	0	0	9336	1145	40	1	1439	1	MATN4	20	43933173	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08		43933173	19092347	69	18907											
MC3R	4159	broad.mit.edu	37	chr20	54824649	54824649	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atcaccattctcctgggcgtGttcatcttctgctgggcccc	9	15	5	0	rs139424256		TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr20:54824649G>C	uc002xxb.2	+	1	862	c.750G>C	c.(748-750)GTG>GTC	p.V250V		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	287	Helical; Name=6; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			TCCTGGGCGTGTTCATCTTCT	0.597													C	54824649	C	C	54824649	2	2	263	1	0	0	0	0	0	0	0	1	9365	1364	48	5		5	MC3R	20	54824649	Silent	SNP	G	TCGA-76-4932-01A-01D-1486-08	10891476	54824649	8200871	70	18908											
C20orf43	51507	broad.mit.edu	37	chr20	55093243	55093243	+	Silent	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tcggaggcctacaagtccctCtttaccactcacagctccgc	7	17	2	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr20:55093243C>G	uc002xxt.2	+	9	950	c.843C>G	c.(841-843)CTC>CTG	p.L281L	C20orf43_uc010zzf.1_Silent_p.L311L|C20orf43_uc002xxu.2_Silent_p.L280L|C20orf43_uc002xxv.2_3'UTR|GCNT7_uc010zzg.1_Intron	NM_016407	NP_057491	Q9BY42	CT043_HUMAN	hypothetical protein LOC51507	281										ovary(1)	1			Colorectal(105;0.202)			ACAAGTCCCTCTTTACCACTC	0.577													G	55093243	G	G	55093243	2	3	263	1	0	0	0	0	0	0	0	1	2112	900	32	5		5	C20orf43	20	55093243	Silent	SNP	C	TCGA-76-4932-01A-01D-1486-08	268594	55093243	7932277	71	18909											
IFNAR2	3455	broad.mit.edu	37	chr21	34625094	34625094	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgagcaagcagtaataaagtCtcccttaaaatgcaccctcc	6	12	1	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr21:34625094C>T	uc002yrd.2	+	7	996	c.668C>T	c.(667-669)TCT>TTT	p.S223F	IFNAR2_uc002yrb.2_Missense_Mutation_p.S223F|IFNAR2_uc002yrc.2_Missense_Mutation_p.S223F|IFNAR2_uc002yre.2_Missense_Mutation_p.S223F|IFNAR2_uc002yrf.2_Missense_Mutation_p.S223F|IFNAR2_uc002yrg.2_Missense_Mutation_p.S92F|IL10RB_uc002yrh.1_Missense_Mutation_p.S73F|IL10RB_uc002yri.1_5'UTR	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	223	Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GTAATAAAGTCTCCCTTAAAA	0.373													T	34625094	T	T	34625094	3	4	263	1	0	0	0	0	1	0	0	0	7545	913	32	3	690	3	IFNAR2	21	34625094	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08		34625094	13504801	72	18910											
TRPM2	7226	broad.mit.edu	37	chr21	45859043	45859043	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaaaacttgctgaagtgcGgcatggaggtattcctggcc	13	8	0	2	rs142254503	byFrequency	TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr21:45859043G>A	uc002zet.1	+	31	4474	c.4261G>A	c.(4261-4263)GGC>AGC	p.G1421S	TRPM2_uc002zeu.1_Missense_Mutation_p.G1421S|TRPM2_uc002zew.1_Missense_Mutation_p.G1421S|TRPM2_uc010gpt.1_Missense_Mutation_p.G1471S|TRPM2_uc002zex.1_Missense_Mutation_p.G1207S|TRPM2_uc002zey.1_Missense_Mutation_p.G900S|TRPM2_uc011aff.1_Missense_Mutation_p.G102S	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1421	Nudix hydrolase.|Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCTGAAGTGCGGCATGGAGGT	0.602													A	45859043	A	A	45859043	3	1	263	1	0	0	0	0	1	0	0	0	16583	1116	39	2	4379	2	TRPM2	21	45859043	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	11233949	45859043	2270852	73	18911											
C21orf29	54084	broad.mit.edu	37	chr21	45948411	45948411	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatcaaaccagaactgggcGtcttccacctcggtacacgg	10	14	2	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr21:45948411G>A	uc002zfe.1	-	6	912	c.846C>T	c.(844-846)GAC>GAT	p.D282D	C21orf29_uc010gpv.1_Silent_p.D214D	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	282					cell adhesion	extracellular region	structural molecule activity				0						AGAACTGGGCGTCTTCCACCT	0.607													A	45948411	A	A	45948411	2	1	263	1	0	0	0	0	0	0	0	1	2124	1136	40	1		1	C21orf29	21	45948411	Silent	SNP	G	TCGA-76-4932-01A-01D-1486-08	89368	45948411	2181484	74	18912											
ZNF280B	140883	broad.mit.edu	37	chr22	22842526	22842526	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctggcacacatagggcatttCgccaggcttatgatggtcct	11	11	0	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr22:22842526C>T	uc002zwc.1	-	4	1974	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TAGGGCATTTCGCCAGGCTTA	0.433													T	22842526	T	T	22842526	3	4	263	1	0	0	0	0	1	0	0	0	17812	893	31	2	437	2	ZNF280B	22	22842526	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08		22842526	28462040	75	18913											
MOV10L1	54456	broad.mit.edu	37	chr22	50596602	50596602	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagtcaggtgtctgccagCgacattggcgtcatcacgcc	11	14	4	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chr22:50596602C>T	uc003bjj.2	+	23	3266	c.3183C>T	c.(3181-3183)AGC>AGT	p.S1061S	MOV10L1_uc003bjk.3_Silent_p.S1061S|MOV10L1_uc011arp.1_Silent_p.S1041S|MOV10L1_uc003bjl.2_Silent_p.S188S|MOV10L1_uc003bjm.1_Silent_p.S104S	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	1061					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TGTCTGCCAGCGACATTGGCG	0.652													T	50596602	T	T	50596602	2	4	263	1	0	0	0	0	0	0	0	1	9719	767	27	1		1	MOV10L1	22	50596602	Silent	SNP	C	TCGA-76-4932-01A-01D-1486-08	27754076	50596602	707964	76	18914											
GLRA2	2742	broad.mit.edu	37	chrX	14599498	14599498	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caacaaattgctacggatttCgaaaaatggcaaagtgctct	8	8	1	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chrX:14599498C>T	uc010nep.2	+	5	796	c.464C>T	c.(463-465)TCG>TTG	p.S155L	GLRA2_uc010neq.2_Missense_Mutation_p.S155L|GLRA2_uc004cwe.3_Missense_Mutation_p.S155L|GLRA2_uc011mio.1_Missense_Mutation_p.S66L|GLRA2_uc011mip.1_Missense_Mutation_p.S133L	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	155	Extracellular (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	CTACGGATTTCGAAAAATGGC	0.453													T	14599498	T	T	14599498	3	4	263	1	0	0	0	0	1	0	0	0	6455	893	31	2	550	2	GLRA2	23	14599498	Missense_Mutation	SNP	C	TCGA-76-4932-01A-01D-1486-08		14599498	140671062	77	18915											
LANCL3	347404	broad.mit.edu	37	chrX	37431325	37431325	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccagggggggctttatggcGgcgtggccggagtggcgtat	21	8	0	0			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chrX:37431325G>A	uc011mkd.1	+	1	504	c.202G>A	c.(202-204)GGC>AGC	p.G68S	LANCL3_uc004ddp.1_Missense_Mutation_p.G68S	NM_198511	NP_940913	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3	68							catalytic activity				0						GCTTTATGGCGGCGTGGCCGG	0.711													A	37431325	A	A	37431325	3	1	263	1	0	0	0	0	1	0	0	0	8622	1116	39	2	204	2	LANCL3	23	37431325	Missense_Mutation	SNP	G	TCGA-76-4932-01A-01D-1486-08	22831827	37431325	117839235	78	18916											
MORC4	79710	broad.mit.edu	37	chrX	106221358	106221358	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gattttatgagtcggttgttAtgatacatcattattccaaa	7	5	1	2			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chrX:106221358A>T	uc004emu.3	-	8	1251	c.1008T>A	c.(1006-1008)CAT>CAA	p.H336Q	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Missense_Mutation_p.H336Q|MORC4_uc004emw.3_Missense_Mutation_p.H84Q	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	336							ATP binding|zinc ion binding			ovary(1)	1						GTCGGTTGTTATGATACATCA	0.393													T	106221358	T	T	106221358	3	4	263	1	0	0	0	0	1	0	0	0	9704	446	16	5	1845	5	MORC4	23	106221358	Missense_Mutation	SNP	A	TCGA-76-4932-01A-01D-1486-08	68790033	106221358	49049202	79	18917											
THOC2	57187	broad.mit.edu	37	chrX	122756613	122756613	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ggcacagtgttcctacctgtTagagccactatttccattgc	8	12	0	1			TCGA-76-4932-01A-01D-1486-08	TCGA-76-4932-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	81656daa-af7c-430c-afa3-0eb10eb9a695	345b16b4-b6d8-43f6-a586-9250153414aa	g.chrX:122756613T>A	uc004etu.2	-	30	3813	c.3781A>T	c.(3781-3783)AAC>TAC	p.N1261Y	THOC2_uc010nqt.1_5'Flank|THOC2_uc004etw.1_Missense_Mutation_p.N82Y	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1261					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TCCTACCTGTTAGAGCCACTA	0.284													A	122756613	A	A	122756613	3	1	263	1	0	0	0	0	1	0	0	0	15862	1754	61	5	1036	5	THOC2	23	122756613	Missense_Mutation	SNP	T	TCGA-76-4932-01A-01D-1486-08	16535255	122756613	32513947	80	18918											
LEPRE1	64175	broad.mit.edu	37	chr1	43215947	43215947	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctccatgatgcgccgcacctTctccgtcacgttgtagtaca	8	15	2	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr1:43215947T>C	uc001chv.2	-	11	1743	c.1630A>G	c.(1630-1632)AAG>GAG	p.K544E	LEPRE1_uc001chw.2_Missense_Mutation_p.K544E|LEPRE1_uc001chx.3_Missense_Mutation_p.K544E	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	544					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CGCCGCACCTTCTCCGTCACG	0.572													C	43215947	C	C	43215947	3	2	264	1	0	0	0	0	1	0	0	0	8729	1792	62	4	619	4	LEPRE1	1	43215947	Missense_Mutation	SNP	T	TCGA-76-4934-01A-01D-1486-08		43215947	206034674	1	18919											
NEXN	91624	broad.mit.edu	37	chr1	78401572	78401572	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	agaactgatcaaattaaaaaGgagtggctctattcaagcta	8	6	3	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr1:78401572G>T	uc001dic.3	+	11	1613	c.1316G>T	c.(1315-1317)AGG>ATG	p.R439M	NEXN_uc001dia.3_Missense_Mutation_p.R425M|NEXN_uc009wcb.1_Missense_Mutation_p.R361M|NEXN_uc001dib.3_Missense_Mutation_p.R375M|NEXN_uc001did.1_Missense_Mutation_p.R349M|NEXN_uc001dif.1_Missense_Mutation_p.R331M|NEXN_uc001dig.3_Missense_Mutation_p.R80M	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	439	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		AAATTAAAAAGGAGTGGCTCT	0.313													T	78401572	T	T	78401572	3	4	264	1	0	0	0	0	1	0	0	0	10355	1000	35	5	1354	5	NEXN	1	78401572	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	35185625	78401572	170849049	2	18920											
LPAR3	23566	broad.mit.edu	37	chr1	85331314	85331314	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaggcaattccagcccagtgTggggaccgcccccataaaaa	11	13	0	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr1:85331314T>C	uc001dkl.2	-	1	529	c.490A>G	c.(490-492)ACA>GCA	p.T164A	LPAR3_uc009wcj.1_Missense_Mutation_p.T164A	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	164	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						CAGCCCAGTGTGGGGACCGCC	0.527													C	85331314	C	C	85331314	3	2	264	1	0	0	0	0	1	0	0	0	8906	1696	59	4	579	4	LPAR3	1	85331314	Missense_Mutation	SNP	T	TCGA-76-4934-01A-01D-1486-08	6929742	85331314	163919307	3	18921											
TDRD10	126668	broad.mit.edu	37	chr1	154493902	154493902	+	Frame_Shift_Del	DEL	A	-	-													aactgttcgtgaatacaagcAaaaggccccccaagaggacc							TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr1:154493902delA	uc009wow.2	+	6	1154	c.316delA	c.(316-318)AAAfs	p.K106fs	TDRD10_uc001ffd.2_Frame_Shift_Del_p.K106fs|TDRD10_uc001ffe.2_Frame_Shift_Del_p.K27fs	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	106	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GAATACAAGCAAAAGGCCCCC	0.517													-	154493902	-	-	154493902	7	5	264	1	0	1	0	1	0	0	0	0	15728	131	5	0	334	0	TDRD10	1	154493902	Frame_Shift_Del	DEL	A	TCGA-76-4934-01A-01D-1486-08	69162588	154493902	94756719	4	18922											
MAP4K3	8491	broad.mit.edu	37	chr2	39515367	39515367	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggacatctcttgattgttcCttgattttcatcctcagtag	8	9	3	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr2:39515367C>A	uc002rro.2	-	20	1460	c.1369G>T	c.(1369-1371)GGA>TGA	p.G457*	MAP4K3_uc002rrp.2_Nonsense_Mutation_p.G436*|MAP4K3_uc010yns.1_Nonsense_Mutation_p.G10*	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	457					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TTGATTGTTCCTTGATTTTCA	0.428													A	39515367	A	A	39515367	4	1	264	1	0	0	0	0	0	1	0	0	9261	690	24	5	1375	5	MAP4K3	2	39515367	Nonsense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08		39515367	203684006	5	18923											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48809103	48809103	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgtgataactcaaatttattGcctctgctttgtgaatggga	9	6	2	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr2:48809103G>T	uc010yol.1	+	1	1378	c.1331G>T	c.(1330-1332)TGC>TTC	p.C444F	STON1_uc002rwo.3_Missense_Mutation_p.C444F|STON1_uc010fbm.2_Missense_Mutation_p.C444F|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.C444F|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.C444F	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	444					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CAAATTTATTGCCTCTGCTTT	0.383													T	48809103	T	T	48809103	3	4	264	1	0	0	0	0	1	0	0	0	15316	1319	46	5	1333	5	STON1-GTF2A1L	2	48809103	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	9293736	48809103	194390270	6	18924											
CCDC85A	114800	broad.mit.edu	37	chr2	56420085	56420085	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggcagcccggagcactccaaGcacaggagcgccagccccga	13	17	0	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr2:56420085G>C	uc002rzn.2	+	2	1252	c.750G>C	c.(748-750)AAG>AAC	p.K250N		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	250	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AGCACTCCAAGCACAGGAGCG	0.662													C	56420085	C	C	56420085	3	2	264	1	0	0	0	0	1	0	0	0	2859	962	34	5	756	5	CCDC85A	2	56420085	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	7610982	56420085	186779288	7	18925											
GLI2	2736	broad.mit.edu	37	chr2	121726342	121726342	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcctgagccgcaagcgggcGctgtccatctccccactctc	10	19	2	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr2:121726342G>A	uc010flp.2	+	5	726	c.696G>A	c.(694-696)GCG>GCA	p.A232A	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Missense_Mutation_p.A103T|GLI2_uc010flo.1_Silent_p.A107A|GLI2_uc002tmw.1_Silent_p.A232A	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	232					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GCAAGCGGGCGCTGTCCATCT	0.632													A	121726342	A	A	121726342	2	1	264	1	0	0	0	0	0	0	0	1	6438	1074	38	1		1	GLI2	2	121726342	Silent	SNP	G	TCGA-76-4934-01A-01D-1486-08	65306257	121726342	121473031	8	18926											
ZDBF2	57683	broad.mit.edu	37	chr2	207173022	207173022	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcagccagtggctggccaacCtgaagaagtagttaaggagg	14	8	1	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr2:207173022C>A	uc002vbp.2	+	5	4020	c.3770C>A	c.(3769-3771)CCT>CAT	p.P1257H		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1257							nucleic acid binding|zinc ion binding			ovary(3)	3						GCTGGCCAACCTGAAGAAGTA	0.383													A	207173022	A	A	207173022	3	1	264	1	0	0	0	0	1	0	0	0	17596	681	24	5	3780	5	ZDBF2	2	207173022	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	85446680	207173022	36026351	9	18927											
PRKAG3	53632	broad.mit.edu	37	chr2	219691740	219691740	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgctgtctccagcaccacaGccaagtctcggaatgtgccg	11	14	2	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr2:219691740G>A	uc002vjb.1	-	10	1098	c.1079C>T	c.(1078-1080)GCT>GTT	p.A360V	PRKAG3_uc010zkn.1_RNA|PRKAG3_uc010fvy.1_Silent_p.L402L	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	360	CBS 3.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGCACCACAGCCAAGTCTCG	0.602													A	219691740	A	A	219691740	3	1	264	1	0	0	0	0	1	0	0	0	12502	971	34	3	406	3	PRKAG3	2	219691740	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	12518718	219691740	23507633	10	18928											
PASK	23178	broad.mit.edu	37	chr2	242065780	242065780	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctcagggccagcatccaaCgtggaaggaacgtgtcctgg	13	12	1	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr2:242065780C>T	uc002wao.1	-	10	2642	c.2550G>A	c.(2548-2550)ACG>ACA	p.T850T	PASK_uc010zol.1_Silent_p.T664T|PASK_uc010zom.1_Silent_p.T815T|PASK_uc010fzl.1_Silent_p.T850T|PASK_uc010zon.1_Silent_p.T631T|PASK_uc002wap.2_Silent_p.T393T|PASK_uc002waq.2_Silent_p.T850T	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	850				T -> M (in Ref. 2; BAA09484).	regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CAGCATCCAACGTGGAAGGAA	0.587													T	242065780	T	T	242065780	2	4	264	1	0	0	0	0	0	0	0	1	11472	523	19	1		1	PASK	2	242065780	Silent	SNP	C	TCGA-76-4934-01A-01D-1486-08	22374040	242065780	1133593	11	18929											
FBXL2	25827	broad.mit.edu	37	chr3	33415165	33415165	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtgcgaggttgtcgaggccTgaaagccctgctcctgaggg	17	10	0	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr3:33415165T>G	uc003cfp.2	+	8	622	c.551T>G	c.(550-552)CTG>CGG	p.L184R	FBXL2_uc011axm.1_RNA|FBXL2_uc011axn.1_RNA|FBXL2_uc011axo.1_Missense_Mutation_p.L79R|FBXL2_uc011axp.1_Missense_Mutation_p.L100R|FBXL2_uc011axq.1_RNA|FBXL2_uc011axr.1_RNA|FBXL2_uc011axs.1_RNA	NM_012157	NP_036289	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	184	LRR 5.				interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			large_intestine(1)	1						TGTCGAGGCCTGAAAGCCCTG	0.552													G	33415165	G	G	33415165	3	3	264	1	0	0	0	0	1	0	0	0	5716	1580	55	5	581	5	FBXL2	3	33415165	Missense_Mutation	SNP	T	TCGA-76-4934-01A-01D-1486-08		33415165	164607265	12	18930											
CSRNP1	64651	broad.mit.edu	37	chr3	39188146	39188146	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gttgtcctcatccagctggtCaaatttcctcttcaacagcc	6	14	4	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr3:39188146C>A	uc003cjg.2	-	2	242	c.28G>T	c.(28-30)GAC>TAC	p.D10Y	CSRNP1_uc003cjh.2_Missense_Mutation_p.D10Y	NM_033027	NP_149016	Q96S65	CSRN1_HUMAN	AXIN1 up-regulated 1	10					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(4)|skin(1)	5						TCCAGCTGGTCAAATTTCCTC	0.587													A	39188146	A	A	39188146	3	1	264	1	0	0	0	0	1	0	0	0	3963	826	29	5	1757	5	CSRNP1	3	39188146	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	5772981	39188146	158834284	13	18931											
C3orf15	89876	broad.mit.edu	37	chr3	119462994	119462994	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctgaagagagtggtcggcGccaggtggaaaaacagcgcc	17	9	0	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr3:119462994G>A	uc003ede.3	+	14	1930	c.1853G>A	c.(1852-1854)CGC>CAC	p.R618H	C3orf15_uc010hqz.2_Missense_Mutation_p.R556H|C3orf15_uc011bjd.1_Missense_Mutation_p.R492H|C3orf15_uc011bje.1_Missense_Mutation_p.R598H	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	454						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		AGTGGTCGGCGCCAGGTGGAA	0.592													A	119462994	A	A	119462994	3	1	264	1	0	0	0	0	1	0	0	0	2209	1087	38	1	1907	1	C3orf15	3	119462994	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	80274848	119462994	78559436	14	18932											
FAM194A	131831	broad.mit.edu	37	chr3	150387205	150387205	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaccatttaccttgttgggCactcgaatgatggctaggtt	10	8	0	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr3:150387205C>T	uc003eyg.2	-	12	1434	c.1377G>A	c.(1375-1377)GTG>GTA	p.V459V	FAM194A_uc003eyh.2_Silent_p.V313V	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	459										skin(2)|ovary(1)	3						CCTTGTTGGGCACTCGAATGA	0.418													T	150387205	T	T	150387205	2	4	264	1	0	0	0	0	0	0	0	1	5526	697	25	3		3	FAM194A	3	150387205	Silent	SNP	C	TCGA-76-4934-01A-01D-1486-08	30924211	150387205	47635225	15	18933											
ZNF595	152687	broad.mit.edu	37	chr4	86956	86956	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	caaagcttttaaccaatcctCaggccttattatacacagga	5	11	1	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr4:86956C>G	uc003fzv.1	+	6	1718	c.1562C>G	c.(1561-1563)TCA>TGA	p.S521*	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Nonsense_Mutation_p.S289*|ZNF595_uc011but.1_Nonsense_Mutation_p.S289*	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	521					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		AACCAATCCTCAGGCCTTATT	0.393													G	86956	G	G	86956	4	3	264	1	0	0	0	0	0	1	0	0	18022	827	29	5	1575	5	ZNF595	4	86956	Nonsense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08		86956	191067320	16	18934											
KIT	3815	broad.mit.edu	37	chr4	55561742	55561742	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccatccatccaggaaaatcAgacttaatagtccgcgtggg	9	11	1	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr4:55561742A>G	uc010igr.2	+	2	219	c.132A>G	c.(130-132)TCA>TCG	p.S44S	KIT_uc010igs.2_Silent_p.S44S	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	44	Extracellular (Potential).|Ig-like C2-type 1.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CAGGAAAATCAGACTTAATAG	0.468		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				G	55561742	G	G	55561742	2	3	264	1	0	0	0	0	0	0	0	1	8329	175	7	4		4	KIT	4	55561742	Silent	SNP	A	TCGA-76-4934-01A-01D-1486-08	55474786	55561742	135592534	17	18935											
GUCY1A3	2982	broad.mit.edu	37	chr4	156634553	156634553	+	Nonsense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tatttccctgtgaggttgctCagcagctgtggcaagggcaa	13	9	1	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr4:156634553C>T	uc003iov.2	+	8	1926	c.1390C>T	c.(1390-1392)CAG>TAG	p.Q464*	GUCY1A3_uc010iqc.2_Nonsense_Mutation_p.Q464*|GUCY1A3_uc003iow.2_Nonsense_Mutation_p.Q464*|GUCY1A3_uc010iqd.2_Nonsense_Mutation_p.Q463*|GUCY1A3_uc003iox.2_Nonsense_Mutation_p.Q464*|GUCY1A3_uc003ioz.2_Nonsense_Mutation_p.Q229*|GUCY1A3_uc003ioy.2_Nonsense_Mutation_p.Q464*|GUCY1A3_uc010iqe.2_Nonsense_Mutation_p.Q229*|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Nonsense_Mutation_p.Q464*	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	464					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TGAGGTTGCTCAGCAGCTGTG	0.522													T	156634553	T	T	156634553	4	4	264	1	0	0	0	0	0	1	0	0	6894	827	29	3	1423	3	GUCY1A3	4	156634553	Nonsense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	101072811	156634553	34519723	18	18936											
NAF1	92345	broad.mit.edu	37	chr4	164050120	164050120	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggcagtggtggagggggagGgggtgggggtagggagtatg	27	1	0	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr4:164050120G>A	uc003iqj.2	-	8	1608	c.1414C>T	c.(1414-1416)CCT>TCT	p.P472S	NAF1_uc010iqw.1_Intron	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	472	Pro-rich.				rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				ggagggggagggggtgggggt	0.254													A	164050120	A	A	164050120	3	1	264	1	0	0	0	0	1	0	0	0	10140	1232	43	3	215	3	NAF1	4	164050120	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	7415567	164050120	27104156	19	18937											
SLC6A3	6531	broad.mit.edu	37	chr5	1422074	1422074	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaggctgtgagctgccaccGcggaggccccaggtcgtcga	16	14	0	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr5:1422074G>A	uc003jck.2	-	5	830	c.709C>T	c.(709-711)CGG>TGG	p.R237W		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	237	Extracellular (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGCTGCCACCGCGGAGGCCCC	0.657													A	1422074	A	A	1422074	3	1	264	1	0	0	0	0	1	0	0	0	14685	1086	38	1	1197	1	SLC6A3	5	1422074	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08		1422074	179493186	20	18938											
NPR3	4883	broad.mit.edu	37	chr5	32724903	32724903	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctacgccttcttcaacattgAgctcttcaacagctcttcct	4	15	5	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr5:32724903A>G	uc003jhv.2	+	2	1087	c.869A>G	c.(868-870)GAG>GGG	p.E290G	NPR3_uc010iuo.2_Missense_Mutation_p.E74G|NPR3_uc011cnz.1_Missense_Mutation_p.E74G|NPR3_uc003jhu.2_Missense_Mutation_p.E290G	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	290	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	TTCAACATTGAGCTCTTCAAC	0.473													G	32724903	G	G	32724903	3	3	264	1	0	0	0	0	1	0	0	0	10596	304	11	4	875	4	NPR3	5	32724903	Missense_Mutation	SNP	A	TCGA-76-4934-01A-01D-1486-08	31302829	32724903	148190357	21	18939											
LYSMD3	116068	broad.mit.edu	37	chr5	89815175	89815175	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	agatgaatgacgtgaagtctGtcttccttttggaggacaaa	11	6	2	4			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr5:89815175G>C	uc003kjr.2	-	3	530	c.382C>G	c.(382-384)CAG>GAG	p.Q128E	LYSMD3_uc010jaz.1_Intron|LYSMD3_uc003kjs.1_Missense_Mutation_p.T108R	NM_198273	NP_938014	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain	128	Extracellular (Potential).				cell wall macromolecule catabolic process	integral to membrane					0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		CGTGAAGTCTGTCTTCCTTTT	0.393													C	89815175	C	C	89815175	3	2	264	1	0	0	0	0	1	0	0	0	9126	1386	48	5	542	5	LYSMD3	5	89815175	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	57090272	89815175	91100085	22	18940											
DTWD2	285605	broad.mit.edu	37	chr5	118324199	118324199	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	gtgttcgtgcctctttctgcGactccatggcggacactccg	11	14	2	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr5:118324199G>T	uc003ksa.2	-	1	42	c.8C>A	c.(7-9)TCG>TAG	p.S3*		NM_173666	NP_775937	Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	3											0		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		CTCTTTCTGCGACTCCATGGC	0.706											OREG0016736	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	118324199	T	T	118324199	4	4	264	1	0	0	0	0	0	1	0	0	4792	1059	37	5	912	5	DTWD2	5	118324199	Nonsense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	28509024	118324199	62591061	23	18941											
PCDHA5	56143	broad.mit.edu	37	chr5	140202968	140202968	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagttccaggtgagcgcGcgcgacgcgggcgtgccgcc	17	15	0	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr5:140202968G>A	uc003lhl.2	+	1	1608	c.1608G>A	c.(1606-1608)GCG>GCA	p.A536A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.A536A|PCDHA5_uc003lhj.1_Silent_p.A536A	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	536	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGAGCGCGCGCGACGCGG	0.677													A	140202968	A	A	140202968	2	1	264	1	0	0	0	0	0	0	0	1	11527	1074	38	1		1	PCDHA5	5	140202968	Silent	SNP	G	TCGA-76-4934-01A-01D-1486-08	21878769	140202968	40712292	24	18942											
KIF4B	285643	broad.mit.edu	37	chr5	154393566	154393566	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gttggtactgataaatccttCacctacgattttgtgtttga	8	7	1	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr5:154393566C>G	uc010jih.1	+	1	307	c.147C>G	c.(145-147)TTC>TTG	p.F49L		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	49	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATAAATCCTTCACCTACGATT	0.488													G	154393566	G	G	154393566	3	3	264	1	0	0	0	0	1	0	0	0	8304	825	29	5	149	5	KIF4B	5	154393566	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	14190598	154393566	26521694	25	18943											
STK10	6793	broad.mit.edu	37	chr5	171510086	171510086	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagctctcggagttcctggCgcctgaaaggttaaaggata	13	8	1	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr5:171510086C>T	uc003mbo.1	-	11	1988	c.1688G>A	c.(1687-1689)CGC>CAC	p.R563H		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	563							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAGTTCCTGGCGCCTGAAAGG	0.468													T	171510086	T	T	171510086	3	4	264	1	0	0	0	0	1	0	0	0	15285	768	27	1	1254	1	STK10	5	171510086	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	17116520	171510086	9405174	26	18944											
CAGE1	285782	broad.mit.edu	37	chr6	7370288	7370288	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagcagattagaatgtgtcGtttttgtatcctacatgcac	10	7	0	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr6:7370288G>A	uc003mxi.2	-	5	2070	c.1349C>T	c.(1348-1350)ACG>ATG	p.T450M	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Missense_Mutation_p.T341M|CAGE1_uc003mxk.1_Missense_Mutation_p.T341M	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	586											0	Ovarian(93;0.0418)					AGAATGTGTCGTTTTTGTATC	0.378													A	7370288	A	A	7370288	3	1	264	1	0	0	0	0	1	0	0	0	2572	1145	40	1	904	1	CAGE1	6	7370288	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08		7370288	163744779	27	18945											
TJAP1	93643	broad.mit.edu	37	chr6	43472961	43472961	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccccgcaacagccccctgCccaactgcacttacgctacc	5	22	0	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr6:43472961C>T	uc003ovd.2	+	11	1418	c.1042C>T	c.(1042-1044)CCC>TCC	p.P348S	TJAP1_uc003ovf.2_Missense_Mutation_p.P338S|TJAP1_uc003ove.2_Missense_Mutation_p.P338S|TJAP1_uc003ovc.2_Missense_Mutation_p.P338S|TJAP1_uc010jyp.2_Missense_Mutation_p.P307S|TJAP1_uc011dvh.1_Missense_Mutation_p.P338S|TJAP1_uc003ovg.2_Missense_Mutation_p.P214S|TJAP1_uc011dvi.1_Missense_Mutation_p.P348S|TJAP1_uc011dvj.1_Missense_Mutation_p.P148S|TJAP1_uc003ovi.2_Missense_Mutation_p.P214S	NM_001146016	NP_001139488	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 isoform a	348						Golgi apparatus|tight junction	protein binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CAGCCCCCTGCCCAACTGCAC	0.512													T	43472961	T	T	43472961	3	4	264	1	0	0	0	0	1	0	0	0	15925	739	26	3	1072	3	TJAP1	6	43472961	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	36102673	43472961	127642106	28	18946											
POM121C	100101267	broad.mit.edu	37	chr7	75048122	75048122	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ttcgggcctgcagtcgctgtCgagcccctggggtcttggat	15	12	1	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr7:75048122C>A	uc003udk.3	-	15	3806	c.2921G>T	c.(2920-2922)CGA>CTA	p.R974L		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	1216	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						CAGTCGCTGTCGAGCCCCTGG	0.592													A	75048122	A	A	75048122	3	1	264	1	0	0	0	0	1	0	0	0	12240	884	31	5	46	5	POM121C	7	75048122	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08		75048122	84090541	29	18947											
COL1A2	1278	broad.mit.edu	37	chr7	94040399	94040399	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagtcgtggtgcaagtggccCtgctggagtccgaggaccta	15	10	0	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr7:94040399C>T	uc003ung.1	+	23	1754	c.1283C>T	c.(1282-1284)CCT>CTT	p.P428L	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	428					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GCAAGTGGCCCTGCTGGAGTC	0.507										HNSCC(75;0.22)			T	94040399	T	T	94040399	3	4	264	1	0	0	0	0	1	0	0	0	3678	681	24	3	1373	3	COL1A2	7	94040399	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	18992277	94040399	65098264	30	18948											
FEZF1	389549	broad.mit.edu	37	chr7	121943310	121943310	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	acactttgcaaacgaagggtCtggctcctgtgtgcactggc	12	11	1	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr7:121943310C>T	uc003vkd.2	-	2	931	c.857G>A	c.(856-858)AGA>AAA	p.R286K	FEZF1_uc003vkc.2_Missense_Mutation_p.R236K|uc010lko.1_5'Flank|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	286					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						AACGAAGGGTCTGGCTCCTGT	0.468													T	121943310	T	T	121943310	3	4	264	1	0	0	0	0	1	0	0	0	5825	913	32	3	582	3	FEZF1	7	121943310	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	27902911	121943310	37195353	31	18949											
FGL1	2267	broad.mit.edu	37	chr8	17726236	17726236	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tattccccaatattcaactcGtagaaattctaaagaaaaag	4	8	2	2	rs142240316		TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr8:17726236G>A	uc003wxx.2	-	8	924	c.600C>T	c.(598-600)TAC>TAT	p.Y200Y	FGL1_uc003wxy.2_Silent_p.Y200Y|FGL1_uc003wxz.2_Silent_p.Y199Y|FGL1_uc003wya.2_Silent_p.Y200Y|FGL1_uc003wyb.2_Silent_p.Y200Y|FGL1_uc003wyc.2_Silent_p.Y200Y|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Silent_p.Y250Y|FGL1_uc003wyf.2_Silent_p.Y170Y	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	200	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		TATTCAACTCGTAGAAATTCT	0.383													A	17726236	A	A	17726236	2	1	264	1	0	0	0	0	0	0	0	1	5872	1140	40	1		1	FGL1	8	17726236	Silent	SNP	G	TCGA-76-4934-01A-01D-1486-08		17726236	128637786	32	18950											
DCAF4L2	138009	broad.mit.edu	37	chr8	88886046	88886046	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctttttcctctgcatgcagcTtacacgcagctcgcgagcta	8	14	1	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr8:88886046T>A	uc003ydz.2	-	1	251	c.154A>T	c.(154-156)AGC>TGC	p.S52C		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	52										ovary(1)	1						TGCATGCAGCTTACACGCAGC	0.507													A	88886046	A	A	88886046	3	1	264	1	0	0	0	0	1	0	0	0	4272	1609	56	5	1037	5	DCAF4L2	8	88886046	Missense_Mutation	SNP	T	TCGA-76-4934-01A-01D-1486-08	71159810	88886046	57477976	33	18951											
LRRC24	441381	broad.mit.edu	37	chr8	145749853	145749853	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcaagaaggtgaaatccagcAgccgcgccagctggttgccc	13	13	0	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr8:145749853A>G	uc003zdm.2	-	3	542	c.410T>C	c.(409-411)CTG>CCG	p.L137P	LRRC24_uc003zdn.2_Missense_Mutation_p.L137P|LRRC14_uc003zdk.1_3'UTR|LRRC14_uc003zdl.1_3'UTR|LRRC14_uc003zdo.2_RNA	NM_001024678	NP_001019849	Q50LG9	LRC24_HUMAN	leucine rich repeat containing 24 precursor	137	LRR 4.					integral to membrane					0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GAAATCCAGCAGCCGCGCCAG	0.662													G	145749853	G	G	145749853	3	3	264	1	0	0	0	0	1	0	0	0	8979	188	7	4	1143	4	LRRC24	8	145749853	Missense_Mutation	SNP	A	TCGA-76-4934-01A-01D-1486-08	56863807	145749853	614169	34	18952											
NUP188	23511	broad.mit.edu	37	chr9	131752466	131752466	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cacaaacatgaccctgctttGccacgtcttgccattcagct	6	15	2	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr9:131752466G>T	uc004bws.1	+	25	2623	c.2601G>T	c.(2599-2601)TTG>TTT	p.L867F	NUP188_uc004bwu.2_Missense_Mutation_p.L210F	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	867					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						ACCCTGCTTTGCCACGTCTTG	0.448													T	131752466	T	T	131752466	3	4	264	1	0	0	0	0	1	0	0	0	10758	1310	46	5	2699	5	NUP188	9	131752466	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08		131752466	9460965	35	18953											
BRD3	8019	broad.mit.edu	37	chr9	136913570	136913570	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctgctttccgcttcacgcCctttttctgcgacagtgaaa	8	13	3	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr9:136913570C>T	uc004cew.2	-	6	909	c.721G>A	c.(721-723)GGC>AGC	p.G241S	BRD3_uc004cex.2_Missense_Mutation_p.G241S	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	241						nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		CGCTTCACGCCCTTTTTCTGC	0.627			T	NUT|C15orf55	lethal midline carcinoma of young people								T	136913570	T	T	136913570	3	4	264	1	0	0	0	0	1	0	0	0	1503	623	22	3	1487	3	BRD3	9	136913570	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	5161104	136913570	4299861	36	18954											
SLC39A12	221074	broad.mit.edu	37	chr10	18276538	18276538	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgtttgtgggcttggccgtCgggacactgtctggggacgc	17	10	1	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr10:18276538C>T	uc001ipo.2	+	7	1500	c.1227C>T	c.(1225-1227)GTC>GTT	p.V409V	SLC39A12_uc001ipn.2_Silent_p.V409V|SLC39A12_uc001ipp.2_Silent_p.V409V|SLC39A12_uc010qck.1_Silent_p.V275V	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	409	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						GCTTGGCCGTCGGGACACTGT	0.502													T	18276538	T	T	18276538	2	4	264	1	0	0	0	0	0	0	0	1	14615	871	31	2		2	SLC39A12	10	18276538	Silent	SNP	C	TCGA-76-4934-01A-01D-1486-08		18276538	117258209	37	18955											
C10orf140	387640	broad.mit.edu	37	chr10	21805467	21805469	+	In_Frame_Del	DEL	CCT	-	-													atccgaggccccgctgccccCctcctcctcctcttcctcct							TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr10:21805467_21805469delCCT	uc009xkd.2	-	4	3536_3538	c.1283_1285delAGG	c.(1282-1287)GAGGGG>GGG	p.E428del	uc001iqp.1_RNA	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	347	Ser-rich.|Glu-rich.			E -> EEE (in Ref. 2; BAD18601 and 4; CAD39106).		nucleus	nucleotide binding			ovary(1)	1						CCGCTGCccccctcctcctcctc	0.438													-	21805469	-	-	21805467	7	5	264	1	0	1	0	1	0	0	0	0	1595	623	22	0	1445	0	C10orf140	10	21805467	In_Frame_Del	DEL	CCT	TCGA-76-4934-01A-01D-1486-08	3528929	21805467	113729280	38	18956											
SVIL	6840	broad.mit.edu	37	chr10	29784039	29784039	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttccaggggtttggaaaCgggtgtggtgcctcttgttt	14	8	1	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr10:29784039C>T	uc001iut.1	-	19	4489	c.3736G>A	c.(3736-3738)GTT>ATT	p.V1246I	SVIL_uc010qdw.1_Missense_Mutation_p.V160I|SVIL_uc001iuu.1_Missense_Mutation_p.V820I|SVIL_uc009xlc.2_Missense_Mutation_p.V38I	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1246					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				GGTTTGGAAACGGGTGTGGTG	0.552													T	29784039	T	T	29784039	3	4	264	1	0	0	0	0	1	0	0	0	15418	536	19	1	2988	1	SVIL	10	29784039	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	7978572	29784039	105750708	39	18957											
PTEN	5728	broad.mit.edu	37	chr10	89692778	89692778	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttttaccacagttgcacaaTatccttttgaagaccataac	4	10	0	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr10:89692778T>C	uc001kfb.2	+	6	1293	c.262T>C	c.(262-264)TAT>CAT	p.Y88H		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	88	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.Y88C(5)|p.R55fs*1(4)|p.?(2)|p.Y27fs*1(2)|p.Y88fs*3(2)|p.Y27_N212>Y(2)|p.Y88N(1)|p.Y88H(1)|p.Q87_P96del(1)|p.Y88S(1)|p.N82_P95del(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGTTGCACAATATCCTTTTGA	0.338		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89692778	C	C	89692778	3	2	264	1	0	0	0	0	1	0	0	0	12738	1406	49	4	280	4	PTEN	10	89692778	Missense_Mutation	SNP	T	TCGA-76-4934-01A-01D-1486-08	59908739	89692778	45841969	40	18958											
OR52E8	390079	broad.mit.edu	37	chr11	5878741	5878741	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atggccaggaagtagtacatAggctcatggagactctgctc	12	9	2	1	rs147064631		TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr11:5878741A>G	uc010qzr.1	-	1	192	c.192T>C	c.(190-192)CCT>CCC	p.P64P	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGTAGTACATAGGCTCATGGA	0.458													G	5878741	G	G	5878741	2	3	264	1	0	0	0	0	0	0	0	1	11118	407	15	4		4	OR52E8	11	5878741	Silent	SNP	A	TCGA-76-4934-01A-01D-1486-08		5878741	129127775	41	18959			1	46		2	2	25	N	C_A	5.349257e-05
OR52E8	390079	broad.mit.edu	37	chr11	5878765	5878765	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tcatggagactctgctcagtCtggatcacaaacaagagagc	10	10	5	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr11:5878765C>T	uc010qzr.1	-	1	168	c.168G>A	c.(166-168)CAG>CAA	p.Q56Q	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	56	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTGCTCAGTCTGGATCACAA	0.483													T	5878765	T	T	5878765	2	4	264	1	0	0	0	0	0	0	0	1	11118	912	32	3		3	OR52E8	11	5878765	Silent	SNP	C	TCGA-76-4934-01A-01D-1486-08	24	5878765	129127751	42	18960			1	46		2	2	25	N	C_A	5.349257e-05
SYT12	91683	broad.mit.edu	37	chr11	66797643	66797643	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tggatgtggcagaataccatCtgagcggtgagtgcccaggg	16	8	1	3			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr11:66797643C>A	uc009yrl.2	+	2	258	c.28C>A	c.(28-30)CTG>ATG	p.L10M	SYT12_uc001oju.2_Missense_Mutation_p.L10M	NM_177963	NP_808878	Q8IV01	SYT12_HUMAN	synaptotagmin XII	10	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane				ovary(1)	1						AGAATACCATCTGAGCGGTGA	0.428													A	66797643	A	A	66797643	3	1	264	1	0	0	0	0	1	0	0	0	15465	912	32	5	30	5	SYT12	11	66797643	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	60918878	66797643	68208873	43	18961											
KDM5A	5927	broad.mit.edu	37	chr12	416979	416979	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttgggaacttgatttaggaaGaggaacacagctgttatgga	13	4	0	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr12:416979G>A	uc001qif.1	-	23	3934	c.3571C>T	c.(3571-3573)CTT>TTT	p.L1191F	KDM5A_uc001qie.1_Missense_Mutation_p.L1191F	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1191	PHD-type 2.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						GATTTAGGAAGAGGAACACAG	0.443			T 	NUP98	AML								A	416979	A	A	416979	3	1	264	1	0	0	0	0	1	0	0	0	8133	942	33	3	1525	3	KDM5A	12	416979	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08		416979	133434916	44	18962											
TNFRSF1A	7132	broad.mit.edu	37	chr12	6442637	6442637	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcttcctgcagccacacacgGtgtcccggtccactgtgcaa	9	16	1	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr12:6442637G>T	uc001qnu.2	-	4	649	c.368C>A	c.(367-369)ACC>AAC	p.T123N	TNFRSF1A_uc001qnt.2_Missense_Mutation_p.T15N|TNFRSF1A_uc010sey.1_Intron|TNFRSF1A_uc010sez.1_Missense_Mutation_p.T15N|TNFRSF1A_uc009zek.2_Missense_Mutation_p.T80N|TNFRSF1A_uc010sfa.1_Missense_Mutation_p.T123N	NM_001065	NP_001056	P19438	TNR1A_HUMAN	tumor necrosis factor receptor 1 precursor	123	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			lung(2)|skin(1)	3						GCCACACACGGTGTCCCGGTC	0.552													T	6442637	T	T	6442637	3	4	264	1	0	0	0	0	1	0	0	0	16290	1261	44	5	1027	5	TNFRSF1A	12	6442637	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	6025658	6442637	127409258	45	18963											
ART4	420	broad.mit.edu	37	chr12	14993552	14993552	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacccaggcaggtgaatatgGtaaatagtgtctggttccca	11	9	1	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr12:14993552G>A	uc001rcl.1	-	2	1046	c.680C>T	c.(679-681)ACC>ATC	p.T227I	ART4_uc009zid.1_Intron|ART4_uc009zie.1_Intron|ART4_uc001rcm.1_Missense_Mutation_p.T227I	NM_021071	NP_066549	Q93070	NAR4_HUMAN	ADP-ribosyltransferase 4 precursor	227					arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity				0						GGTGAATATGGTAAATAGTGT	0.463													A	14993552	A	A	14993552	3	1	264	1	0	0	0	0	1	0	0	0	999	1261	44	3	272	3	ART4	12	14993552	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	8550915	14993552	118858343	46	18964											
KRT73	319101	broad.mit.edu	37	chr12	53011874	53011874	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agacccaccttgtcaatgaaGgaggcgaacttgttgttcag	11	9	2	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr12:53011874G>A	uc001sas.2	-	1	470	c.435C>T	c.(433-435)TCC>TCT	p.S145S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	145	Coil 1A.|Rod.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTCAATGAAGGAGGCGAACT	0.547													A	53011874	A	A	53011874	2	1	264	1	0	0	0	0	0	0	0	1	8486	987	35	3		3	KRT73	12	53011874	Silent	SNP	G	TCGA-76-4934-01A-01D-1486-08	38018322	53011874	80840021	47	18965											
LRP1	4035	broad.mit.edu	37	chr12	57581169	57581169	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agacccgcccaggggccttcGagcgtgagaccgtcatcact	12	15	2	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr12:57581169G>T	uc001snd.2	+	42	7427	c.6961G>T	c.(6961-6963)GAG>TAG	p.E2321*		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2321	LDL-receptor class B 22.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGGGGCCTTCGAGCGTGAGAC	0.607													T	57581169	T	T	57581169	4	4	264	1	0	0	0	0	0	1	0	0	8951	1059	37	5	7127	5	LRP1	12	57581169	Nonsense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	4569295	57581169	76270726	48	18966											
LRIG3	121227	broad.mit.edu	37	chr12	59274532	59274532	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgcataattttccatttcAgcatcatgcagtagttcatt	6	8	3	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr12:59274532A>G	uc001sqr.2	-	13	1878	c.1632T>C	c.(1630-1632)GCT>GCC	p.A544A	LRIG3_uc009zqh.2_Silent_p.A484A|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	544	Ig-like C2-type 1.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			TTTCCATTTCAGCATCATGCA	0.488													G	59274532	G	G	59274532	2	3	264	1	0	0	0	0	0	0	0	1	8946	175	7	4		4	LRIG3	12	59274532	Silent	SNP	A	TCGA-76-4934-01A-01D-1486-08	1693363	59274532	74577363	49	18967											
TPTE2	93492	broad.mit.edu	37	chr13	20039688	20039688	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aataataagtcgtagaagtcGaactaaatgtgtccatctaa	7	6	1	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr13:20039688G>A	uc001umd.2	-	9	740	c.529C>T	c.(529-531)CGA>TGA	p.R177*	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Nonsense_Mutation_p.R66*|TPTE2_uc001ume.2_Nonsense_Mutation_p.R100*|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	177						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CGTAGAAGTCGAACTAAATGT	0.289													A	20039688	A	A	20039688	4	1	264	1	0	0	0	0	0	1	0	0	16428	1066	37	2	1091	2	TPTE2	13	20039688	Nonsense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08		20039688	95130190	50	18968											
MPHOSPH8	54737	broad.mit.edu	37	chr13	20235946	20235946	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaacggtcggcagaagaacGggaccaccgccctcattcat	11	13	2	3			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr13:20235946G>A	uc001umh.2	+	8	1909	c.1900G>A	c.(1900-1902)GGG>AGG	p.G634R	MPHOSPH8_uc001umg.2_Missense_Mutation_p.G634R	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	634	ANK 2.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		GCAGAAGAACGGGACCACCGC	0.552													A	20235946	A	A	20235946	3	1	264	1	0	0	0	0	1	0	0	0	9727	1116	39	2	1930	2	MPHOSPH8	13	20235946	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	196258	20235946	94933932	51	18969											
NALCN	259232	broad.mit.edu	37	chr13	101728226	101728226	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttaacaatgtacttacatGttttccacagatggagaaaa	6	7	1	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr13:101728226G>A	uc001vox.1	-	35	4141	c.3952C>T	c.(3952-3954)CAT>TAT	p.H1318Y		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1318	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GTACTTACATGTTTTCCACAG	0.323													A	101728226	A	A	101728226	3	1	264	1	0	0	0	0	1	0	0	0	10148	1377	48	3	1304	3	NALCN	13	101728226	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	81492280	101728226	13441652	52	18970											
BATF	10538	broad.mit.edu	37	chr14	76012841	76012841	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agaaacagaacgcggctctaCgcaaggagatcaagcagctc	11	11	2	3			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr14:76012841C>T	uc001xrr.2	+	3	447	c.205C>T	c.(205-207)CGC>TGC	p.R69C		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	69	Leucine-zipper.					nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.028)		CGCGGCTCTACGCAAGGAGAT	0.612													T	76012841	T	T	76012841	3	4	264	1	0	0	0	0	1	0	0	0	1325	536	19	1	215	1	BATF	14	76012841	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08		76012841	31336699	53	18971											
HEATR3	55027	broad.mit.edu	37	chr16	50112858	50112858	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	atggggatgatttgattgaaGatgatgaaatggaaggaatt	14	0	0	6			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr16:50112858G>C	uc002efw.2	+	7	1132	c.970G>C	c.(970-972)GAT>CAT	p.D324H	HEATR3_uc002efx.2_Missense_Mutation_p.D238H	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	324							binding			ovary(1)|skin(1)	2						TTTGATTGAAGATGATGAAAT	0.368													C	50112858	C	C	50112858	3	2	264	1	0	0	0	0	1	0	0	0	7029	942	33	5	996	5	HEATR3	16	50112858	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08		50112858	40241895	54	18972											
SLC12A3	6559	broad.mit.edu	37	chr16	56904089	56904089	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cattttcgctttcgccaatgCcgtgggtgtggccatgcaca	11	12	0	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr16:56904089C>T	uc010ccm.2	+	5	712	c.683C>T	c.(682-684)GCC>GTC	p.A228V	SLC12A3_uc002ekd.3_Missense_Mutation_p.A228V|SLC12A3_uc010ccn.2_Missense_Mutation_p.A227V	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	228	Helical; (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TTCGCCAATGCCGTGGGTGTG	0.662													T	56904089	T	T	56904089	3	4	264	1	0	0	0	0	1	0	0	0	14384	739	26	3	701	3	SLC12A3	16	56904089	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	6791231	56904089	33450664	55	18973											
ZC3H18	124245	broad.mit.edu	37	chr16	88688690	88688690	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggaaggacccttggcgcCgatccaagtctcccaagaag	12	12	1	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr16:88688690C>T	uc002fky.2	+	9	1761	c.1561C>T	c.(1561-1563)CGA>TGA	p.R521*	ZC3H18_uc010voz.1_Nonsense_Mutation_p.R545*|ZC3H18_uc010chw.2_RNA	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	521						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CCCTTGGCGCCGATCCAAGTC	0.602													T	88688690	T	T	88688690	4	4	264	1	0	0	0	0	0	1	0	0	17565	644	23	2	1591	2	ZC3H18	16	88688690	Nonsense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	31784601	88688690	1666063	56	18974											
TP53	7157	broad.mit.edu	37	chr17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccaggacaggcacaaacaCgcacctcaaagctgttccgt	8	15	1	0	rs28934576	by1000genomes	TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577120	T	T	7577120	3	4	264	1	0	0	0	0	1	0	0	0	16378	536	19	1	468	1	TP53	17	7577120	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08		7577120	73618090	57	18975											
KRT16	3868	broad.mit.edu	37	chr17	39766792	39766792	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctcctccaggctgttctcCagggatgctttctgcaagtg	11	12	3	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr17:39766792C>T	uc002hxg.3	-	6	1210	c.1071G>A	c.(1069-1071)CTG>CTA	p.L357L	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	357	Rod.|Coil 2.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				GGCTGTTCTCCAGGGATGCTT	0.522													T	39766792	T	T	39766792	2	4	264	1	0	0	0	0	0	0	0	1	8453	581	21	3		3	KRT16	17	39766792	Silent	SNP	C	TCGA-76-4934-01A-01D-1486-08	32189672	39766792	41428418	58	18976											
NDC80	10403	broad.mit.edu	37	chr18	2610820	2610820	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgggaaataacttgcaacGtctgttagagatggttgcta	12	5	1	1	rs144795559		TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr18:2610820G>A	uc002kli.2	+	16	1933	c.1751G>A	c.(1750-1752)CGT>CAT	p.R584H		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	584	Potential.|Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex.|Interaction with NEK2 and ZWINT.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						AACTTGCAACGTCTGTTAGAG	0.373													A	2610820	A	A	2610820	3	1	264	1	0	0	0	0	1	0	0	0	10242	1145	40	1	1809	1	NDC80	18	2610820	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08		2610820	75466428	59	18977											
PCSK4	54760	broad.mit.edu	37	chr19	1482471	1482471	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagcgtgtagcggtacaacGtccctggacaggggtcgcgg	17	11	0	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr19:1482471G>A	uc002ltb.1	-	14	1762	c.1700C>T	c.(1699-1701)ACG>ATG	p.T567M	PCSK4_uc002lsz.2_Missense_Mutation_p.T54M|PCSK4_uc002lta.2_Silent_p.D337D	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	567					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGTACAACGTCCCTGGACA	0.687													A	1482471	A	A	1482471	3	1	264	1	0	0	0	0	1	0	0	0	11602	1145	40	1	575	1	PCSK4	19	1482471	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08		1482471	57646512	60	18978											
GPATCH1	55094	broad.mit.edu	37	chr19	33579113	33579113	+	Frame_Shift_Del	DEL	C	-	-													aaaggaaggtataaacgattCcacggggcctttagtggagg							TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr19:33579113delC	uc002nug.1	+	2	461	c.147delC	c.(145-147)TTCfs	p.F49fs		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	49						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					ATAAACGATTCCACGGGGCCT	0.353													-	33579113	-	-	33579113	7	5	264	1	0	1	0	1	0	0	0	0	6590	854	30	0	153	0	GPATCH1	19	33579113	Frame_Shift_Del	DEL	C	TCGA-76-4934-01A-01D-1486-08	32096642	33579113	25549870	61	18979											
PSG11	5680	broad.mit.edu	37	chr19	43523198	43523198	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gatggagggcttgggagtctCcactgtgcagaaaacagaga	15	7	1	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr19:43523198C>G	uc002ovm.1	-	3	540	c.433G>C	c.(433-435)GAG>CAG	p.E145Q	PSG11_uc002ouw.2_Missense_Mutation_p.E151Q|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.E151Q|PSG11_uc002ovn.1_Missense_Mutation_p.E151Q|PSG11_uc002ovo.1_Missense_Mutation_p.E23Q|PSG11_uc002ovp.1_Missense_Mutation_p.E23Q	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	145					female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTGGGAGTCTCCACTGTGCAG	0.507													G	43523198	G	G	43523198	3	3	264	1	0	0	0	0	1	0	0	0	12654	864	30	5	586	5	PSG11	19	43523198	Missense_Mutation	SNP	C	TCGA-76-4934-01A-01D-1486-08	9944085	43523198	15605785	62	18980											
CD40	958	broad.mit.edu	37	chr20	44750990	44750990	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgccaccagcacaaatactgCgaccccagtgcgtgcgctgt	10	15	0	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr20:44750990C>T	uc002xrg.1	+	3	326	c.249C>T	c.(247-249)TGC>TGT	p.C83C	CD40_uc002xrf.1_Silent_p.C83C|CD40_uc002xrh.1_Silent_p.C83C|CD40_uc002xri.1_Silent_p.C83C|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	83	TNFR-Cys 2.|Extracellular (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	ACAAATACTGCGACCCCAGTG	0.393									Immune_Deficiency_with_Hyper-IgM				T	44750990	T	T	44750990	2	4	264	1	0	0	0	0	0	0	0	1	3015	776	27	1		1	CD40	20	44750990	Silent	SNP	C	TCGA-76-4934-01A-01D-1486-08		44750990	18274530	63	18981											
ALG12	79087	broad.mit.edu	37	chr22	50307405	50307405	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgcctgcctgatgaccccttTccagccattccaggctttca	7	17	1	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chr22:50307405T>C	uc003biy.2	-	2	283	c.9A>G	c.(7-9)GGA>GGG	p.G3G		NM_024105	NP_077010	Q9BV10	ALG12_HUMAN	alpha-1,6-mannosyltransferase ALG12	3					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane					0		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		BRCA - Breast invasive adenocarcinoma(115;0.199)|LUAD - Lung adenocarcinoma(64;0.247)		ATGACCCCTTTCCAGCCATTC	0.597													C	50307405	C	C	50307405	2	2	264	1	0	0	0	0	0	0	0	1	514	1770	62	4		4	ALG12	22	50307405	Silent	SNP	T	TCGA-76-4934-01A-01D-1486-08		50307405	997161	64	18982											
ARSE	415	broad.mit.edu	37	chrX	2867360	2867360	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgaccttttgagaaaggacGcaacctcctgcagaataagg	10	10	0	3			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chrX:2867360G>A	uc004crc.3	-	6	1089	c.839C>T	c.(838-840)GCG>GTG	p.A280V	ARSE_uc011mhi.1_Missense_Mutation_p.A226V|ARSE_uc011mhh.1_Missense_Mutation_p.A305V	NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	280					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GAGAAAGGACGCAACCTCCTG	0.453													A	2867360	A	A	2867360	3	1	264	1	0	0	0	0	1	0	0	0	990	1087	38	1	954	1	ARSE	23	2867360	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08		2867360	152403200	65	18983											
CACNA1F	778	broad.mit.edu	37	chrX	49065814	49065814	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtcacaggtgagggcctgccGcatctcaggacccaagtcct	12	14	2	1			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chrX:49065814G>T	uc004dnb.2	-	42	4956	c.4894C>A	c.(4894-4896)CGG>AGG	p.R1632R	CACNA1F_uc010nip.2_Silent_p.R1621R	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1632	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	AGGGCCTGCCGCATCTCAGGA	0.423													T	49065814	T	T	49065814	2	4	264	1	0	0	0	0	0	0	0	1	2543	1086	38	5		5	CACNA1F	23	49065814	Silent	SNP	G	TCGA-76-4934-01A-01D-1486-08	46198454	49065814	106204746	66	18984											
STARD8	9754	broad.mit.edu	37	chrX	67937331	67937331	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcctcagccccacccaggGccaggagggtccccaggaca	11	19	1	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chrX:67937331G>A	uc004dxa.2	+	5	707	c.335G>A	c.(334-336)GGC>GAC	p.G112D	STARD8_uc004dxb.2_Missense_Mutation_p.G192D|STARD8_uc004dxc.3_Missense_Mutation_p.G112D	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	112					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						CCCACCCAGGGCCAGGAGGGT	0.637													A	67937331	A	A	67937331	3	1	264	1	0	0	0	0	1	0	0	0	15262	1203	42	3	597	3	STARD8	23	67937331	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	18871517	67937331	87333229	67	18985											
CXorf57	55086	broad.mit.edu	37	chrX	105855563	105855563	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgttagaggatgagccacgcGacacggtgcccaagcctccc	12	14	0	2			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chrX:105855563G>A	uc004emi.3	+	1	404	c.253G>A	c.(253-255)GAC>AAC	p.D85N	CXorf57_uc004emj.3_Missense_Mutation_p.D85N|CXorf57_uc004emh.2_Missense_Mutation_p.D85N	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	85										ovary(1)|lung(1)|breast(1)	3						TGAGCCACGCGACACGGTGCC	0.572													A	105855563	A	A	105855563	3	1	264	1	0	0	0	0	1	0	0	0	4113	1058	37	2	255	2	CXorf57	23	105855563	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	37918232	105855563	49414997	68	18986											
ZNF280C	55609	broad.mit.edu	37	chrX	129354388	129354388	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtacgatgctgcgccttatGttcagctttctccttgctgg	10	11	2	0			TCGA-76-4934-01A-01D-1486-08	TCGA-76-4934-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	e9bc4701-562e-4d35-a949-53a61fd96651	1e7fd821-8432-49f0-82a4-2423b216c9c4	g.chrX:129354388G>A	uc004evm.2	-	13	1616	c.1462C>T	c.(1462-1464)CAT>TAT	p.H488Y	ZNF280C_uc010nrf.1_Missense_Mutation_p.H439Y	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	488	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						TGCGCCTTATGTTCAGCTTTC	0.383													A	129354388	A	A	129354388	3	1	264	1	0	0	0	0	1	0	0	0	17813	1377	48	3	779	3	ZNF280C	23	129354388	Missense_Mutation	SNP	G	TCGA-76-4934-01A-01D-1486-08	23498825	129354388	25916172	69	18987											
AADACL4	343066	broad.mit.edu	37	chr1	12726232	12726232	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcagttgccatcctttcagcAgaaccaaaatgtcccattac	6	13	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr1:12726232A>G	uc001auf.2	+	4	710	c.710A>G	c.(709-711)CAG>CGG	p.Q237R		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	237	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TCCTTTCAGCAGAACCAAAAT	0.517													G	12726232	G	G	12726232	3	3	265	1	0	0	0	0	1	0	0	0	13	188	7	4	724	4	AADACL4	1	12726232	Missense_Mutation	SNP	A	TCGA-76-4935-01A-01D-1486-08		12726232	236524389	1	18988											
C1orf173	127254	broad.mit.edu	37	chr1	75038917	75038917	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gagggatctcccttttttctGtaaactcttctgccaattct	6	11	5	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr1:75038917G>C	uc001dgg.2	-	14	2696	c.2477C>G	c.(2476-2478)ACA>AGA	p.T826R		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	826	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCTTTTTTCTGTAAACTCTTC	0.582													C	75038917	C	C	75038917	3	2	265	1	0	0	0	0	1	0	0	0	2014	1377	48	5	2119	5	C1orf173	1	75038917	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	62312685	75038917	174211704	2	18989											
MAGI3	260425	broad.mit.edu	37	chr1	114215328	114215328	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accttgcacagcctgacaccGcagtaatttcagttgtaggc	9	12	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr1:114215328G>A	uc001edk.2	+	18	3191	c.3010G>A	c.(3010-3012)GCA>ACA	p.A1004T	MAGI3_uc001edh.3_Missense_Mutation_p.A1029T|MAGI3_uc001edi.3_Missense_Mutation_p.A1004T|MAGI3_uc010owm.1_Missense_Mutation_p.A1029T|MAGI3_uc001edj.2_Missense_Mutation_p.A725T	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1029					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCTGACACCGCAGTAATTTC	0.458													A	114215328	A	A	114215328	3	1	265	1	0	0	0	0	1	0	0	0	9192	1087	38	1	3080	1	MAGI3	1	114215328	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	39176411	114215328	135035293	3	18990											
MTMR11	10903	broad.mit.edu	37	chr1	149906114	149906114	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtcgaacctctcgttgaccGtgctgaccctccagcctctg	9	17	2	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr1:149906114G>A	uc001etl.3	-	7	904	c.653C>T	c.(652-654)ACG>ATG	p.T218M	MTMR11_uc001etm.1_Missense_Mutation_p.T146M|MTMR11_uc010pbm.1_Missense_Mutation_p.T190M|MTMR11_uc010pbn.1_Missense_Mutation_p.T60M	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	218	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CTCGTTGACCGTGCTGACCCT	0.572													A	149906114	A	A	149906114	3	1	265	1	0	0	0	0	1	0	0	0	9940	1145	40	1	1559	1	MTMR11	1	149906114	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	35690786	149906114	99344507	4	18991											
PLXNA2	5362	broad.mit.edu	37	chr1	208391207	208391207	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cagcacccagaccactgagaGcaggaccacagagcggctgt	12	14	0	3			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr1:208391207G>T	uc001hgz.2	-	2	819	c.61C>A	c.(61-63)CTC>ATC	p.L21I	PLXNA2_uc001hha.3_Missense_Mutation_p.L75I	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	21					axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ACCACTGAGAGCAGGACCACA	0.657													T	208391207	T	T	208391207	3	4	265	1	0	0	0	0	1	0	0	0	12120	971	34	5	5747	5	PLXNA2	1	208391207	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	58485093	208391207	40859414	5	18992											
C2orf39	92749	broad.mit.edu	37	chr2	26647184	26647184	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aagaccagccaggacaaattCgatgaaatcacctcaaagtg	8	10	2	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr2:26647184C>T	uc002rhg.2	+	4	476	c.402C>T	c.(400-402)TTC>TTT	p.F134F	C2orf39_uc010eym.1_Intron	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	134	Potential.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGACAAATTCGATGAAATCA	0.498													T	26647184	T	T	26647184	2	4	265	1	0	0	0	0	0	0	0	1	2164	883	31	2		2	C2orf39	2	26647184	Silent	SNP	C	TCGA-76-4935-01A-01D-1486-08		26647184	216552189	6	18993											
SRBD1	55133	broad.mit.edu	37	chr2	45801787	45801787	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agttccgaatgaagtcaagcGtgtctttgtctttagcaatc	9	8	3	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr2:45801787G>A	uc002rus.2	-	8	1224	c.1148C>T	c.(1147-1149)ACG>ATG	p.T383M		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	383					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			GAAGTCAAGCGTGTCTTTGTC	0.393													A	45801787	A	A	45801787	3	1	265	1	0	0	0	0	1	0	0	0	15132	1145	40	1	1895	1	SRBD1	2	45801787	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	19154603	45801787	197397586	7	18994											
GALNT5	11227	broad.mit.edu	37	chr2	158165186	158165186	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcacccttgtgataacagAaacaaagggctaaaatggct	9	9	0	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr2:158165186A>G	uc002tzg.2	+	9	2883	c.2628A>G	c.(2626-2628)AGA>AGG	p.R876R	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	876	Lumenal (Potential).|Ricin B-type lectin.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						GTGATAACAGAAACAAAGGGC	0.388													G	158165186	G	G	158165186	2	3	265	1	0	0	0	0	0	0	0	1	6216	243	9	4		4	GALNT5	2	158165186	Silent	SNP	A	TCGA-76-4935-01A-01D-1486-08	112363399	158165186	85034187	8	18995											
LY75	4065	broad.mit.edu	37	chr2	160755282	160755282	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ttgagattgctgtgccatgtCcatccttcagagccagccgg	11	12	1	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr2:160755282C>A	uc002ubc.3	-	2	452	c.383G>T	c.(382-384)GGA>GTA	p.G128V	LY75_uc002ubb.3_Missense_Mutation_p.G128V|LY75_uc010fos.2_Missense_Mutation_p.G128V|LY75_uc010fot.1_Missense_Mutation_p.G128V	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	128	Extracellular (Potential).|Ricin B-type lectin.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TGTGCCATGTCCATCCTTCAG	0.522													A	160755282	A	A	160755282	3	1	265	1	0	0	0	0	1	0	0	0	9099	855	30	5	4921	5	LY75	2	160755282	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	2590096	160755282	82444091	9	18996											
VIL1	7429	broad.mit.edu	37	chr2	219294359	219294359	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aatctggtggtgagggaagtCgccacacggccactgacaca	13	11	1	2	rs148795202		TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr2:219294359C>T	uc002via.2	+	8	875	c.810C>T	c.(808-810)GTC>GTT	p.V270V	VIL1_uc010zke.1_5'UTR|VIL1_uc002vib.2_Silent_p.V270V|VIL1_uc002vic.1_Silent_p.V270V	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	270	Core.|Gelsolin-like 3.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGAGGGAAGTCGCCACACGGC	0.622													T	219294359	T	T	219294359	2	4	265	1	0	0	0	0	0	0	0	1	17161	871	31	2		2	VIL1	2	219294359	Silent	SNP	C	TCGA-76-4935-01A-01D-1486-08	58539077	219294359	23905014	10	18997											
SPEG	10290	broad.mit.edu	37	chr2	220344732	220344732	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcgggcgagcagcaggtgCggatctgtgactttgggaat	17	8	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr2:220344732C>T	uc010fwg.2	+	25	5212	c.5212C>T	c.(5212-5214)CGG>TGG	p.R1738W		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1738	Protein kinase 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCAGCAGGTGCGGATCTGTGA	0.572													T	220344732	T	T	220344732	3	4	265	1	0	0	0	0	1	0	0	0	15035	759	27	1	5322	1	SPEG	2	220344732	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	1050373	220344732	22854641	11	18998											
D2HGDH	728294	broad.mit.edu	37	chr2	242681957	242681957	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catcctctccactgcccgcaTgaaccgggtcctcagcttcc	7	19	2	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr2:242681957T>C	uc002wce.1	+	4	631	c.458T>C	c.(457-459)ATG>ACG	p.M153T	D2HGDH_uc010zpc.1_RNA|D2HGDH_uc010fzq.1_Missense_Mutation_p.M19T|D2HGDH_uc002wcg.1_RNA	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	153	FAD-binding PCMH-type.				2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		ACTGCCCGCATGAACCGGGTC	0.642													C	242681957	C	C	242681957	3	2	265	1	0	0	0	0	1	0	0	0	4213	1464	51	4	468	4	D2HGDH	2	242681957	Missense_Mutation	SNP	T	TCGA-76-4935-01A-01D-1486-08	22337225	242681957	517416	12	18999											
GOLGA4	2803	broad.mit.edu	37	chr3	37366849	37366849	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttttcttcaagagcagctaGttgaactgaagatgctggca	10	8	2	4			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr3:37366849G>A	uc003cgv.2	+	14	3776	c.3472G>A	c.(3472-3474)GTT>ATT	p.V1158I	GOLGA4_uc010hgr.1_Missense_Mutation_p.V719I|GOLGA4_uc003cgw.2_Missense_Mutation_p.V1180I|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.V1039I	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1158	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						AGAGCAGCTAGTTGAACTGAA	0.383													A	37366849	A	A	37366849	3	1	265	1	0	0	0	0	1	0	0	0	6555	1029	36	3	3596	3	GOLGA4	3	37366849	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08		37366849	160655581	13	19000											
CEP63	80254	broad.mit.edu	37	chr3	134225989	134225989	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaagcagaactacaggagcTcatgaaacagattgacataa	9	7	1	5			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr3:134225989T>C	uc003eqo.1	+	4	532	c.83T>C	c.(82-84)CTC>CCC	p.L28P	CEP63_uc003eql.1_Missense_Mutation_p.L28P|CEP63_uc003eqm.2_Missense_Mutation_p.L28P|CEP63_uc003eqn.1_Missense_Mutation_p.L28P	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	28	Potential.				cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						CTACAGGAGCTCATGAAACAG	0.363													C	134225989	C	C	134225989	3	2	265	1	0	0	0	0	1	0	0	0	3257	1551	54	4	89	4	CEP63	3	134225989	Missense_Mutation	SNP	T	TCGA-76-4935-01A-01D-1486-08	96859140	134225989	63796441	14	19001											
HTR3D	200909	broad.mit.edu	37	chr3	183756271	183756271	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcttcatcacccacctgctgCacgtggccaccacccagccc	6	21	3	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr3:183756271C>A	uc011bqv.1	+	7	994	c.994C>A	c.(994-996)CAC>AAC	p.H332N	HTR3D_uc003fmj.2_Missense_Mutation_p.H157N|HTR3D_uc011bqu.1_Missense_Mutation_p.H282N|HTR3D_uc010hxp.2_Missense_Mutation_p.H111N	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	332	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCACCTGCTGCACGTGGCCAC	0.652													A	183756271	A	A	183756271	3	1	265	1	0	0	0	0	1	0	0	0	7447	710	25	5	1190	5	HTR3D	3	183756271	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	49530282	183756271	14266159	15	19002											
TRIML2	205860	broad.mit.edu	37	chr4	189018255	189018255	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgctgagtcctcttatgtgGcataaactcaggtctgtgat	10	9	3	2	rs144128750		TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr4:189018255G>A	uc003izl.2	-	6	591	c.555C>T	c.(553-555)TGC>TGT	p.C185C	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Silent_p.C260C	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	185	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		CTCTTATGTGGCATAAACTCA	0.493													A	189018255	A	A	189018255	2	1	265	1	0	0	0	0	0	0	0	1	16548	1195	42	3		3	TRIML2	4	189018255	Silent	SNP	G	TCGA-76-4935-01A-01D-1486-08		189018255	2136021	16	19003											
HCN1	348980	broad.mit.edu	37	chr5	45262592	45262592	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacaggagggctgcagaccgCggtggtgtaggagcagggtg	20	7	0	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr5:45262592C>T	uc003jok.2	-	8	2129	c.2104G>A	c.(2104-2106)GCG>ACG	p.A702T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	702	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTGCAGACCGCGGTGGTGTAG	0.592													T	45262592	T	T	45262592	3	4	265	1	0	0	0	0	1	0	0	0	6996	768	27	1	572	1	HCN1	5	45262592	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08		45262592	135652668	17	19004											
RGNEF	64283	broad.mit.edu	37	chr5	73048878	73048878	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggtgacgcaggccaatcGcctcacagcctgcagccacc	11	17	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr5:73048878G>A	uc011csq.1	+	3	337	c.326G>A	c.(325-327)CGC>CAC	p.R109H	RGNEF_uc003kcx.2_Missense_Mutation_p.R109H|RGNEF_uc003kcy.1_Missense_Mutation_p.R109H|RGNEF_uc010izf.2_Missense_Mutation_p.R109H	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	109					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		CAGGCCAATCGCCTCACAGCC	0.617													A	73048878	A	A	73048878	3	1	265	1	0	0	0	0	1	0	0	0	13283	1087	38	1	336	1	RGNEF	5	73048878	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	27786286	73048878	107866382	18	19005											
FBXO38	81545	broad.mit.edu	37	chr5	147807459	147807459	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aagactaccctcggaggcccCtaaccagggccaggagcaga	12	14	0	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr5:147807459C>A	uc003lpf.1	+	15	2722	c.2602C>A	c.(2602-2604)CTA>ATA	p.L868I	FBXO38_uc003lpg.1_Intron|FBXO38_uc003lph.2_Intron	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	868						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGAGGCCCCTAACCAGGGC	0.562													A	147807459	A	A	147807459	3	1	265	1	0	0	0	0	1	0	0	0	5746	680	24	5	2656	5	FBXO38	5	147807459	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	74758581	147807459	33107801	19	19006											
FOXI1	2299	broad.mit.edu	37	chr5	169535162	169535162	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gtttcctctagcacagcctcCttggccttagagaagacaga	9	12	1	3			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr5:169535162C>A	uc003mai.3	+	2	729	c.684C>A	c.(682-684)TCC>TCA	p.S228S	FOXI1_uc003maj.3_Intron	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	228					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCACAGCCTCCTTGGCCTTAG	0.532									Pendred_syndrome				A	169535162	A	A	169535162	2	1	265	1	0	0	0	0	0	0	0	1	6009	668	24	5		5	FOXI1	5	169535162	Silent	SNP	C	TCGA-76-4935-01A-01D-1486-08	21727703	169535162	11380098	20	19007											
DAXX	1616	broad.mit.edu	37	chr6	33286946	33286946	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaggtgggctgggcagggtaCatatctttttcccattcttc	11	9	2	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr6:33286946C>A	uc003oec.2	-	7	2195	c.1991G>T	c.(1990-1992)TGT>TTT	p.C664F	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Missense_Mutation_p.C589F|DAXX_uc011dre.1_Missense_Mutation_p.C676F|DAXX_uc003oed.2_Missense_Mutation_p.C664F	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	664	Interaction with SPOP.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						GGGCAGGGTACATATCTTTTT	0.542			Mis|F|N		Pancreatic neuroendocrine tumors								A	33286946	A	A	33286946	3	1	265	1	0	0	0	0	1	0	0	0	4243	478	17	5	239	5	DAXX	6	33286946	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08		33286946	137828121	21	19008											
ABCB5	340273	broad.mit.edu	37	chr7	20782599	20782599	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttatccctcagtattgagCgaggaaagacagtagcattt	10	8	1	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr7:20782599C>T	uc003suw.3	+	16	2335	c.1789C>T	c.(1789-1791)CGA>TGA	p.R597*	ABCB5_uc010kuh.2_Nonsense_Mutation_p.R1042*	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	597	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CAGTATTGAGCGAGGAAAGAC	0.483													T	20782599	T	T	20782599	4	4	265	1	0	0	0	0	0	1	0	0	44	760	27	1	3259	1	ABCB5	7	20782599	Nonsense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08		20782599	138356064	22	19009											
C7orf60	154743	broad.mit.edu	37	chr7	112461814	112461814	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctatattaacttaaaagtaaTatggggtcttctagctcata	6	6	3	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr7:112461814T>C	uc003vgo.1	-	5	1330	c.1203A>G	c.(1201-1203)ATA>ATG	p.I401M	C7orf60_uc011kms.1_Missense_Mutation_p.I427M	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	401										ovary(2)|skin(1)	3						TTAAAAGTAATATGGGGTCTT	0.358													C	112461814	C	C	112461814	3	2	265	1	0	0	0	0	1	0	0	0	2407	1396	49	4	18	4	C7orf60	7	112461814	Missense_Mutation	SNP	T	TCGA-76-4935-01A-01D-1486-08	91679215	112461814	46676849	23	19010											
PPP1R3A	5506	broad.mit.edu	37	chr7	113518832	113518832	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccttcatgtggatcaaacGctgtttcctttacctcgatg	7	12	2	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr7:113518832G>A	uc010ljy.1	-	4	2346	c.2315C>T	c.(2314-2316)GCG>GTG	p.A772V		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	772					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TGGATCAAACGCTGTTTCCTT	0.403													A	113518832	A	A	113518832	3	1	265	1	0	0	0	0	1	0	0	0	12371	1087	38	1	1057	1	PPP1R3A	7	113518832	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	1057018	113518832	45619831	24	19011											
OR2A1	346528	broad.mit.edu	37	chr7	144015510	144015510	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctttgctggctgcatgaCgcagacctttctctgtttga	9	12	1	3			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr7:144015510C>T	uc011kud.1	+	1	275	c.275C>T	c.(274-276)ACG>ATG	p.T92M	OR2A9P_uc003wec.1_Intron	NM_001001802	NP_001001802	Q8NGT9	OR2A1_HUMAN	olfactory receptor, family 2, subfamily A,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.14)					GGCTGCATGACGCAGACCTTT	0.577													T	144015510	T	T	144015510	3	4	265	1	0	0	0	0	1	0	0	0	10974	536	19	1	295	1	OR2A1	7	144015510	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	30496678	144015510	15123153	25	19012											
GIMAP1	170575	broad.mit.edu	37	chr7	150417468	150417468	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccagttgggtcggttcaccGcccaggaccagcaggcggtg	15	14	1	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr7:150417468G>A	uc003whq.2	+	3	463	c.376G>A	c.(376-378)GCC>ACC	p.A126T	GIMAP1_uc003whp.2_Missense_Mutation_p.A134T	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	126	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCGGTTCACCGCCCAGGACCA	0.637													A	150417468	A	A	150417468	3	1	265	1	0	0	0	0	1	0	0	0	6379	1087	38	1	382	1	GIMAP1	7	150417468	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	6401958	150417468	8721195	26	19013											
FAM110B	90362	broad.mit.edu	37	chr8	59059573	59059573	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ccctccagcggtctaagtcaGacttgagtgacagatatttc	9	11	2	4			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr8:59059573G>C	uc003xtj.1	+	5	1664	c.784G>C	c.(784-786)GAC>CAC	p.D262H		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	262						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				GTCTAAGTCAGACTTGAGTGA	0.562													C	59059573	C	C	59059573	3	2	265	1	0	0	0	0	1	0	0	0	5397	942	33	5	786	5	FAM110B	8	59059573	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08		59059573	87304449	27	19014											
ZFHX4	79776	broad.mit.edu	37	chr8	77768255	77768255	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tttctccaaacagcacatttCaaaagtgagggagaccgttg	9	9	2	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr8:77768255C>G	uc003yav.2	+	10	9350	c.8963C>G	c.(8962-8964)TCA>TGA	p.S2988*	ZFHX4_uc003yau.1_Nonsense_Mutation_p.S3033*|ZFHX4_uc003yaw.1_Nonsense_Mutation_p.S2988*	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2988						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGCACATTTCAAAAGTGAGG	0.537										HNSCC(33;0.089)			G	77768255	G	G	77768255	4	3	265	1	0	0	0	0	0	1	0	0	17632	838	29	5	9132	5	ZFHX4	8	77768255	Nonsense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	18708682	77768255	68595767	28	19015											
FAM83H	286077	broad.mit.edu	37	chr8	144808629	144808629	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccctggcccagtgacagaCgccgcgggctctcgggttgg	15	15	1	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr8:144808629C>T	uc003yzk.2	-	5	3071	c.3002G>A	c.(3001-3003)CGT>CAT	p.R1001H	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1001					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CAGTGACAGACGCCGCGGGCT	0.697													T	144808629	T	T	144808629	3	4	265	1	0	0	0	0	1	0	0	0	5640	536	19	1	541	1	FAM83H	8	144808629	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	67040374	144808629	1555393	29	19016											
PIP5K1B	8395	broad.mit.edu	37	chr9	71509330	71509330	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcaatcaggaggcattaatAtcaggattgtggtgatgaac	12	5	2	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr9:71509330A>G	uc004agu.2	+	8	852	c.547A>G	c.(547-549)ATC>GTC	p.I183V	PIP5K1B_uc011lrq.1_Missense_Mutation_p.I183V|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	183	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		AGGCATTAATATCAGGATTGT	0.373													G	71509330	G	G	71509330	3	3	265	1	0	0	0	0	1	0	0	0	11940	449	16	4	565	4	PIP5K1B	9	71509330	Missense_Mutation	SNP	A	TCGA-76-4935-01A-01D-1486-08		71509330	69704101	30	19017											
C9orf79	286234	broad.mit.edu	37	chr9	90501883	90501883	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	tcccaggagctttccttcctCcatccctgcacccagcagat	6	18	0	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr9:90501883C>G	uc004app.3	+	4	2516	c.2481C>G	c.(2479-2481)CTC>CTG	p.L827L	C9orf79_uc004apo.1_Silent_p.L639L	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	827						integral to membrane				ovary(3)	3						TTTCCTTCCTCCATCCCTGCA	0.562													G	90501883	G	G	90501883	2	3	265	1	0	0	0	0	0	0	0	1	2497	842	30	5		5	C9orf79	9	90501883	Silent	SNP	C	TCGA-76-4935-01A-01D-1486-08	18992553	90501883	50711548	31	19018											
PTEN	5728	broad.mit.edu	37	chr10	89720805	89720808	+	Frame_Shift_Del	DEL	CTTT	-	-													caaggaatatctagtacttaCtttaacaaaaaatgatcttg							TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr10:89720805_89720808delCTTT	uc001kfb.2	+	9	1987_1990	c.956_959delCTTT	c.(955-960)ACTTTAfs	p.T319fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	319_320	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.T319fs*1(22)|p.L318fs*2(11)|p.T319fs*6(6)|p.R55fs*1(4)|p.T319fs*24(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.T319del(2)|p.L320*(2)|p.T319_K332del(1)|p.G165_*404del(1)|p.G165_K342del(1)|p.L316fs*1(1)|p.T319fs*4(1)|p.T319fs*5(1)|p.W274_F341del(1)|p.V317_K322del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTAGTACTTACTTTAACAAAAAAT	0.328		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89720808	-	-	89720805	7	5	265	1	0	1	0	1	0	0	0	0	12738	565	20	0	986	0	PTEN	10	89720805	Frame_Shift_Del	DEL	CTTT	TCGA-76-4935-01A-01D-1486-08		89720805	45813942	32	19019											
C10orf12	26148	broad.mit.edu	37	chr10	98743678	98743678	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gatttggaaaagcaagaaaaGgtcacggaaatgtaggagtt	13	3	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr10:98743678G>T	uc001kmv.2	+	1	2638	c.2531G>T	c.(2530-2532)AGG>ATG	p.R844M		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	844										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AGCAAGAAAAGGTCACGGAAA	0.393													T	98743678	T	T	98743678	3	4	265	1	0	0	0	0	1	0	0	0	1589	1000	35	5	2533	5	C10orf12	10	98743678	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	9022873	98743678	36791069	33	19020											
CTBP2	1488	broad.mit.edu	37	chr10	126727602	126727602	+	Nonsense_Mutation	SNP	T	A	A													caatcgctgtctcttgacttTgtgcttatccacaagggcca					rs76555439		TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr10:126727602T>A	uc009yak.2	-	3	309	c.22A>T	c.(22-24)AAA>TAA	p.K8*	CTBP2_uc009yal.2_Nonsense_Mutation_p.K8*|CTBP2_uc001lif.3_Nonsense_Mutation_p.K8*|CTBP2_uc001lih.3_Nonsense_Mutation_p.K8*	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	8					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CTCTTGACTTTGTGCTTATCC	0.453													A	126727602	A	A	126727602	4	1	265	1	0	0	0	0	0	1	0	0	3998	1821	63	5	3033	5	CTBP2	10	126727602	Nonsense_Mutation	SNP	T	TCGA-76-4935-01A-01D-1486-08	27983924	126727602	8807145	34	19021	23	2									
CTBP2	1488	broad.mit.edu	37	chr10	126727604	126727604	+	Missense_Mutation	SNP	T	C	C													atcgctgtctcttgactttgTgcttatccacaagggccatt					rs3208567		TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr10:126727604T>C	uc009yak.2	-	3	307	c.20A>G	c.(19-21)CAC>CGC	p.H7R	CTBP2_uc009yal.2_Missense_Mutation_p.H7R|CTBP2_uc001lif.3_Missense_Mutation_p.H7R|CTBP2_uc001lih.3_Missense_Mutation_p.H7R	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	7					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CTTGACTTTGTGCTTATCCAC	0.453													C	126727604	C	C	126727604	3	2	265	1	0	0	0	0	1	0	0	0	3998	1696	59	4	3035	4	CTBP2	10	126727604	Missense_Mutation	SNP	T	TCGA-76-4935-01A-01D-1486-08	2	126727604	8807143	35	19022	23	2									
AMPD3	272	broad.mit.edu	37	chr11	10514962	10514962	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tgctgcgcttcatcaagcacAcataccagacggagcctgac	9	14	2	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr11:10514962A>T	uc001mio.1	+	7	1341	c.1006A>T	c.(1006-1008)ACA>TCA	p.T336S	AMPD3_uc010rbz.1_Missense_Mutation_p.T177S|AMPD3_uc001min.1_Missense_Mutation_p.T345S|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.T343S|AMPD3_uc009yfy.2_Missense_Mutation_p.T336S	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	336					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CATCAAGCACACATACCAGAC	0.612													T	10514962	T	T	10514962	3	4	265	1	0	0	0	0	1	0	0	0	587	159	6	5	1079	5	AMPD3	11	10514962	Missense_Mutation	SNP	A	TCGA-76-4935-01A-01D-1486-08		10514962	124491554	36	19023											
VWA5A	4013	broad.mit.edu	37	chr11	124007318	124007318	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agaagtatgcctcaaatataCactccagggcaagacttttg	8	9	1	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr11:124007318C>G	uc001pzu.2	+	14	1771	c.1562C>G	c.(1561-1563)ACA>AGA	p.T521R	VWA5A_uc001pzt.2_Missense_Mutation_p.T521R	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	521										upper_aerodigestive_tract(1)|ovary(1)	2						CTCAAATATACACTCCAGGGC	0.378													G	124007318	G	G	124007318	3	3	265	1	0	0	0	0	1	0	0	0	17239	478	17	5	1612	5	VWA5A	11	124007318	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	113492356	124007318	10999198	37	19024											
DYRK4	8798	broad.mit.edu	37	chr12	4721722	4721722	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ggtgcagatgggaaccttctCttcgcatgaccccggaccag	12	13	1	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr12:4721722C>T	uc001qmx.2	+	12	1319	c.1159C>T	c.(1159-1161)CTT>TTT	p.L387F	DYRK4_uc009zeh.1_Missense_Mutation_p.L502F|DYRK4_uc001qmy.1_Missense_Mutation_p.L387F|DYRK4_uc001qmz.1_Missense_Mutation_p.L101F|DYRK4_uc001qna.1_Missense_Mutation_p.L24F|DYRK4_uc010ser.1_Missense_Mutation_p.L24F	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	387	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			GGAACCTTCTCTTCGCATGAC	0.448													T	4721722	T	T	4721722	3	4	265	1	0	0	0	0	1	0	0	0	4858	913	32	3	1197	3	DYRK4	12	4721722	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08		4721722	129130173	38	19025											
ABCC9	10060	broad.mit.edu	37	chr12	21997717	21997717	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttaccttattggtccaaggaTtatcttattgagaaggttgt	9	5	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr12:21997717T>C	uc001rfi.1	-	25	3249	c.3229A>G	c.(3229-3231)ATC>GTC	p.I1077V	ABCC9_uc001rfh.2_Missense_Mutation_p.I1077V|ABCC9_uc001rfj.1_Missense_Mutation_p.I1041V	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1077	ABC transmembrane type-1 2.|Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GGTCCAAGGATTATCTTATTG	0.368													C	21997717	C	C	21997717	3	2	265	1	0	0	0	0	1	0	0	0	59	1493	52	4	1618	4	ABCC9	12	21997717	Missense_Mutation	SNP	T	TCGA-76-4935-01A-01D-1486-08	17275995	21997717	111854178	39	19026											
HOXC11	3227	broad.mit.edu	37	chr12	54367099	54367099	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggcgcagatttcggcgagcGagggagctgcgcctccaacc	16	13	0	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr12:54367099G>A	uc001sem.2	+	1	190	c.74G>A	c.(73-75)CGA>CAA	p.R25Q		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	25					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTCGGCGAGCGAGGGAGCTGC	0.617			T	NUP98	AML								A	54367099	A	A	54367099	3	1	265	1	0	0	0	0	1	0	0	0	7310	1058	37	2	76	2	HOXC11	12	54367099	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	32369382	54367099	79484796	40	19027											
TMTC2	160335	broad.mit.edu	37	chr12	83289748	83289748	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcggacagcctcctcacccGcactctcaccttcttctact	4	19	4	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr12:83289748G>A	uc001szt.2	+	3	1238	c.806G>A	c.(805-807)CGC>CAC	p.R269H	TMTC2_uc001szr.1_Missense_Mutation_p.R269H|TMTC2_uc001szs.1_Missense_Mutation_p.R269H|TMTC2_uc010suk.1_Missense_Mutation_p.R24H	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	269						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CTCCTCACCCGCACTCTCACC	0.527													A	83289748	A	A	83289748	3	1	265	1	0	0	0	0	1	0	0	0	16258	1087	38	1	816	1	TMTC2	12	83289748	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	28922649	83289748	50562147	41	19028											
HNF1A	6927	broad.mit.edu	37	chr12	121437175	121437175	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgagcgccctggccagcCtcacgcccaccaagcaggta	10	18	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr12:121437175C>T	uc001tzg.2	+	8	1629	c.1606C>T	c.(1606-1608)CTC>TTC	p.L536F	HNF1A_uc010szn.1_Missense_Mutation_p.L536F	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	536					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCTGGCCAGCCTCACGCCCAC	0.672									Hepatic_Adenoma_Familial_Clustering_of				T	121437175	T	T	121437175	3	4	265	1	0	0	0	0	1	0	0	0	7251	681	24	3	1636	3	HNF1A	12	121437175	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	38147427	121437175	12414720	42	19029											
DZIP1	22873	broad.mit.edu	37	chr13	96234520	96234520	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgtcgctccaatcagtcaCagttactaagctgcttttta	7	10	2	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr13:96234520C>T	uc001vmk.2	-	23	3424	c.2572G>A	c.(2572-2574)GTG>ATG	p.V858M	DZIP1_uc010afn.2_5'Flank|DZIP1_uc001vmi.2_Missense_Mutation_p.V106M|DZIP1_uc001vmj.2_Missense_Mutation_p.V334M|DZIP1_uc001vml.2_Missense_Mutation_p.V839M|DZIP1_uc001vmm.2_RNA	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	858					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			CAATCAGTCACAGTTACTAAG	0.408													T	96234520	T	T	96234520	3	4	265	1	0	0	0	0	1	0	0	0	4863	478	17	3	35	3	DZIP1	13	96234520	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08		96234520	18935358	43	19030											
OR4K5	79317	broad.mit.edu	37	chr14	20388930	20388930	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgacttctgataccagcctGcactcccctatgtactttct	6	14	2	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr14:20388930G>T	uc010tkw.1	+	1	165	c.165G>T	c.(163-165)CTG>CTT	p.L55L		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATACCAGCCTGCACTCCCCTA	0.408													T	20388930	T	T	20388930	2	4	265	1	0	0	0	0	0	0	0	1	11073	1306	46	5		5	OR4K5	14	20388930	Silent	SNP	G	TCGA-76-4935-01A-01D-1486-08		20388930	86960610	44	19031											
ZFYVE26	23503	broad.mit.edu	37	chr14	68274502	68274502	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccagcagggcctgtgctgGctggggagactgcctcagga	16	12	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr14:68274502G>A	uc001xka.2	-	5	638	c.499C>T	c.(499-501)CCA>TCA	p.P167S	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.P167S|ZFYVE26_uc010tta.1_Missense_Mutation_p.P167S	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	167					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCCTGTGCTGGCTGGGGAGAC	0.607													A	68274502	A	A	68274502	3	1	265	1	0	0	0	0	1	0	0	0	17665	1203	42	3	7272	3	ZFYVE26	14	68274502	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	47885572	68274502	39075038	45	19032											
PSEN1	5663	broad.mit.edu	37	chr14	73678621	73678621	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgtccaggaactttccagcaGtatcctcgctggtgaagacc	10	12	0	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr14:73678621G>C	uc001xnr.2	+	10	1384	c.1100G>C	c.(1099-1101)AGT>ACT	p.S367T	PSEN1_uc001xnv.2_Missense_Mutation_p.S363T|PSEN1_uc010ark.2_Missense_Mutation_p.S363T|PSEN1_uc001xnt.1_RNA|PSEN1_uc001xnu.2_RNA	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	367	Required for interaction with CTNNB1.|Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		CTTTCCAGCAGTATCCTCGCT	0.493													C	73678621	C	C	73678621	3	2	265	1	0	0	0	0	1	0	0	0	12650	1029	36	5	1130	5	PSEN1	14	73678621	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	5404119	73678621	33670919	46	19033											
NOX5	79400	broad.mit.edu	37	chr15	69328195	69328195	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtacacggttcggcctccccGacaggtgtcgctctgctgct	12	15	1	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr15:69328195G>A	uc002ars.1	+	7	1127	c.1107G>A	c.(1105-1107)CCG>CCA	p.P369P	NOX5_uc002arp.1_Silent_p.P351P|NOX5_uc002arq.1_Silent_p.P323P|NOX5_uc010bid.1_Silent_p.P334P|NOX5_uc002arr.1_Silent_p.P341P|NOX5_uc010bie.1_Silent_p.P169P|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	369	Ferric oxidoreductase.|Helical; (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						CGGCCTCCCCGACAGGTGTCG	0.632													A	69328195	A	A	69328195	2	1	265	1	0	0	0	0	0	0	0	1	10559	1045	37	2		2	NOX5	15	69328195	Silent	SNP	G	TCGA-76-4935-01A-01D-1486-08		69328195	33203197	47	19034											
OTOA	146183	broad.mit.edu	37	chr16	21726417	21726417	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcaggtcctgagaagtgccGtctcccagtatgtatccgac	11	13	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr16:21726417G>A	uc002djh.2	+	13	1433	c.1432G>A	c.(1432-1434)GTC>ATC	p.V478I	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.V399I|OTOA_uc002dji.2_Missense_Mutation_p.V154I|OTOA_uc010vbk.1_Missense_Mutation_p.V126I	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	492					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		GAGAAGTGCCGTCTCCCAGTA	0.577													A	21726417	A	A	21726417	3	1	265	1	0	0	0	0	1	0	0	0	11302	1145	40	1	1528	1	OTOA	16	21726417	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08		21726417	68628336	48	19035											
HERPUD1	9709	broad.mit.edu	37	chr16	56970643	56970643	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gctggttctaatcggggacaGtatcctgaggattcctcaag	12	9	2	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr16:56970643G>C	uc002eke.1	+	4	754	c.345G>C	c.(343-345)CAG>CAC	p.Q115H	HERPUD1_uc010vhj.1_Missense_Mutation_p.Q176H|HERPUD1_uc002ekf.1_Missense_Mutation_p.Q114H|HERPUD1_uc002ekg.1_Missense_Mutation_p.Q90H|HERPUD1_uc010cco.1_Missense_Mutation_p.Q176H|HERPUD1_uc010ccp.1_Missense_Mutation_p.Q175H|HERPUD1_uc002ekh.1_5'UTR	NM_014685	NP_055500	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum	115	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0						ATCGGGGACAGTATCCTGAGG	0.448			T	ERG	prostate								C	56970643	C	C	56970643	3	2	265	1	0	0	0	0	1	0	0	0	7063	1020	36	5	359	5	HERPUD1	16	56970643	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	35244226	56970643	33384110	49	19036											
ANKFY1	51479	broad.mit.edu	37	chr17	4084568	4084568	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgcgaataagaaagcaggCggtgggctcgttgttttcat	13	8	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr17:4084568C>T	uc002fxq.1	-	16	2259	c.2221G>A	c.(2221-2223)GCC>ACC	p.A741T	ANKFY1_uc002fxn.2_Missense_Mutation_p.A783T|ANKFY1_uc002fxo.2_Missense_Mutation_p.A742T|ANKFY1_uc002fxp.2_Missense_Mutation_p.A740T|ANKFY1_uc010ckp.2_Missense_Mutation_p.A683T	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	741	ANK 12.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						AGAAAGCAGGCGGTGGGCTCG	0.522													T	4084568	T	T	4084568	3	4	265	1	0	0	0	0	1	0	0	0	626	768	27	1	1328	1	ANKFY1	17	4084568	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08		4084568	77110642	50	19037											
USP6	9098	broad.mit.edu	37	chr17	5037255	5037255	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggacgtgaggacgactctccGgaaccatgtcttctttaggg	13	10	3	1	rs138849740	byFrequency	TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr17:5037255G>A	uc002gau.1	+	15	2688	c.458G>A	c.(457-459)CGG>CAG	p.R153Q	USP6_uc002gav.1_Missense_Mutation_p.R153Q|USP6_uc010ckz.1_5'UTR|USP6_uc002gaw.2_Missense_Mutation_p.R214Q|uc002gay.1_5'Flank|uc002gba.2_5'Flank|uc002gbb.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	153	Rab-GAP TBC.				protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						ACGACTCTCCGGAACCATGTC	0.562			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								A	5037255	A	A	5037255	3	1	265	1	0	0	0	0	1	0	0	0	17083	1116	39	2	480	2	USP6	17	5037255	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	952687	5037255	76157955	51	19038											
MYH13	8735	broad.mit.edu	37	chr17	10250061	10250061	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcacccttggacagcacaggCccttcagcatttctgcagaa	8	14	3	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr17:10250061C>T	uc002gmk.1	-	13	1289	c.1199G>A	c.(1198-1200)GGC>GAC	p.G400D	MYH13_uc010vvf.1_Missense_Mutation_p.G75D	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	400	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						ACAGCACAGGCCCTTCAGCAT	0.458													T	10250061	T	T	10250061	3	4	265	1	0	0	0	0	1	0	0	0	10032	739	26	3	4733	3	MYH13	17	10250061	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	5212806	10250061	70945149	52	19039											
KIF2B	84643	broad.mit.edu	37	chr17	51900577	51900577	+	Silent	SNP	G	T	T													tgggtcacggtagagtgggtGgagaaagcagtcaaaaaagg							TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr17:51900577G>T	uc002iua.2	+	1	339	c.183G>T	c.(181-183)GTG>GTT	p.V61V		NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	61					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TAGAGTGGGTGGAGAAAGCAG	0.557													T	51900577	T	T	51900577	2	4	265	1	0	0	0	0	0	0	0	1	8298	1335	47	5		5	KIF2B	17	51900577	Silent	SNP	G	TCGA-76-4935-01A-01D-1486-08	41650516	51900577	29294633	53	19040	24	2									
KIF2B	84643	broad.mit.edu	37	chr17	51900579	51900579	+	Missense_Mutation	SNP	A	G	G													ggtcacggtagagtgggtggAgaaagcagtcaaaaaaggca							TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr17:51900579A>G	uc002iua.2	+	1	341	c.185A>G	c.(184-186)GAG>GGG	p.E62G		NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	62					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GAGTGGGTGGAGAAAGCAGTC	0.552													G	51900579	G	G	51900579	3	3	265	1	0	0	0	0	1	0	0	0	8298	304	11	4	187	4	KIF2B	17	51900579	Missense_Mutation	SNP	A	TCGA-76-4935-01A-01D-1486-08	2	51900579	29294631	54	19041	24	2									
GRIN2C	2905	broad.mit.edu	37	chr17	72845978	72845978	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaccatcacactgatgcccGtctccacaaagggtacagag	8	15	2	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr17:72845978G>A	uc002jlt.1	-	7	1742	c.1586C>T	c.(1585-1587)ACG>ATG	p.T529M	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.T529M	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	529	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	ACTGATGCCCGTCTCCACAAA	0.627													A	72845978	A	A	72845978	3	1	265	1	0	0	0	0	1	0	0	0	6781	1145	40	1	2143	1	GRIN2C	17	72845978	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08	20945399	72845978	8349232	55	19042											
MC5R	4161	broad.mit.edu	37	chr18	13826125	13826125	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgacaatgtgtttgactccAtgatctgcatttccgtggtg	10	8	1	3			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr18:13826125A>G	uc010xaf.1	+	1	361	c.361A>G	c.(361-363)ATG>GTG	p.M121V		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	121	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						GTTTGACTCCATGATCTGCAT	0.517													G	13826125	G	G	13826125	3	3	265	1	0	0	0	0	1	0	0	0	9367	217	8	4	363	4	MC5R	18	13826125	Missense_Mutation	SNP	A	TCGA-76-4935-01A-01D-1486-08		13826125	64251123	56	19043											
MAN2B1	4125	broad.mit.edu	37	chr19	12769127	12769127	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaactggtgggggccatccgCgtaagggaagaagtcgtcat	16	8	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr19:12769127C>T	uc002mub.2	-	9	1217	c.1141G>A	c.(1141-1143)GCG>ACG	p.A381T	MAN2B1_uc010dyv.1_Missense_Mutation_p.A380T	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	381					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						GGGCCATCCGCGTAAGGGAAG	0.617													T	12769127	T	T	12769127	3	4	265	1	0	0	0	0	1	0	0	0	9216	768	27	1	1958	1	MAN2B1	19	12769127	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08		12769127	46359856	57	19044											
NLRP5	126206	broad.mit.edu	37	chr19	56565093	56565093	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctgaagagcctggatctcaCggacaatgccctgggtgacg	13	12	1	3			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr19:56565093C>T	uc002qmj.2	+	13	3218	c.3218C>T	c.(3217-3219)ACG>ATG	p.T1073M	NLRP5_uc002qmi.2_Missense_Mutation_p.T1054M	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	1073	LRR 12.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTGGATCTCACGGACAATGCC	0.587													T	56565093	T	T	56565093	3	4	265	1	0	0	0	0	1	0	0	0	10480	536	19	1	3268	1	NLRP5	19	56565093	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	43795966	56565093	2563890	58	19045											
TNNC2	7125	broad.mit.edu	37	chr20	44453472	44453472	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcctcagcctgctggtccGtctgcaggagacacagagaa	13	12	2	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chr20:44453472G>A	uc002xpr.2	-	2	71	c.5C>T	c.(4-6)ACG>ATG	p.T2M		NM_003279	NP_003270	P02585	TNNC2_HUMAN	fast skeletal muscle troponin C	2				TD -> DT (in Ref. 6; AA sequence).	muscle filament sliding|regulation of muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(115;0.0122)				CTGCTGGTCCGTCTGCAGGAG	0.612													A	44453472	A	A	44453472	3	1	265	1	0	0	0	0	1	0	0	0	16322	1159	40	1	497	1	TNNC2	20	44453472	Missense_Mutation	SNP	G	TCGA-76-4935-01A-01D-1486-08		44453472	18572048	59	19046											
MXRA5	25878	broad.mit.edu	37	chrX	3240193	3240193	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttggttgagtagaaaaagtcTctgatggggcaaaagttgtg	14	3	1	3			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:3240193T>C	uc004crg.3	-	5	3690	c.3533A>G	c.(3532-3534)GAG>GGG	p.E1178G		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1178						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AGAAAAAGTCTCTGATGGGGC	0.488													C	3240193	C	C	3240193	3	2	265	1	0	0	0	0	1	0	0	0	10003	1551	54	4	4965	4	MXRA5	23	3240193	Missense_Mutation	SNP	T	TCGA-76-4935-01A-01D-1486-08		3240193	152030367	60	19047											
RAI2	10742	broad.mit.edu	37	chrX	17818870	17818870	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gttattttcagccttgacttCgccgctggggtggttgggct	14	9	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:17818870C>T	uc004cyf.2	-	3	1831	c.1261G>A	c.(1261-1263)GAA>AAA	p.E421K	RAI2_uc004cyg.2_Missense_Mutation_p.E421K|RAI2_uc010nfa.2_Missense_Mutation_p.E421K|RAI2_uc004cyh.3_Missense_Mutation_p.E421K|RAI2_uc011miy.1_Missense_Mutation_p.E371K	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	421					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					GCCTTGACTTCGCCGCTGGGG	0.567													T	17818870	T	T	17818870	3	4	265	1	0	0	0	0	1	0	0	0	13009	893	31	2	335	2	RAI2	23	17818870	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	14578677	17818870	137451690	61	19048											
KLHL34	257240	broad.mit.edu	37	chrX	21675213	21675213	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cgagtacacgcgccgcagtaCgtcggcgggaaccaggccaa	14	14	0	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:21675213C>G	uc004czz.1	-	1	1236	c.694G>C	c.(694-696)GTA>CTA	p.V232L		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	232	BACK.									ovary(1)	1						CGCCGCAGTACGTCGGCGGGA	0.667													G	21675213	G	G	21675213	3	3	265	1	0	0	0	0	1	0	0	0	8387	536	19	5	1244	5	KLHL34	23	21675213	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	3856343	21675213	133595347	62	19049											
DUSP21	63904	broad.mit.edu	37	chrX	44703624	44703624	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcgtgactcgcgtctctaCgacttttttgaccccattgc	8	14	1	2			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:44703624C>T	uc004dgd.2	+	1	376	c.246C>T	c.(244-246)TAC>TAT	p.Y82Y		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	82	Tyrosine-protein phosphatase.|Sufficient for mitochondrial localization (By similarity).					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						CGCGTCTCTACGACTTTTTTG	0.542													T	44703624	T	T	44703624	2	4	265	1	0	0	0	0	0	0	0	1	4820	547	19	1		1	DUSP21	23	44703624	Silent	SNP	C	TCGA-76-4935-01A-01D-1486-08	23028411	44703624	110566936	63	19050											
EDA2R	60401	broad.mit.edu	37	chrX	65819404	65819404	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	actgtgtttccccccaaggtCtcagctccagtataggaggc	10	13	1	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:65819404C>T	uc004dwq.2	-	5	827	c.816G>A	c.(814-816)GAG>GAA	p.E272E	EDA2R_uc004dwr.2_Intron|EDA2R_uc004dws.2_Silent_p.E272E|EDA2R_uc011mpb.1_RNA|EDA2R_uc011mpc.1_Silent_p.E148E|EDA2R_uc010nkt.1_Silent_p.E272E|EDA2R_uc004dwt.1_Silent_p.E293E	NM_021783	NP_068555	Q9HAV5	TNR27_HUMAN	X-linked ectodysplasin receptor	272	Cytoplasmic (Potential).				cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			upper_aerodigestive_tract(1)	1						CCCCCAAGGTCTCAGCTCCAG	0.547													T	65819404	T	T	65819404	2	4	265	1	0	0	0	0	0	0	0	1	4904	912	32	3		3	EDA2R	23	65819404	Silent	SNP	C	TCGA-76-4935-01A-01D-1486-08	21115780	65819404	89451156	64	19051											
PCDH11X	27328	broad.mit.edu	37	chrX	91873723	91873723	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	agtcaggcccaatcatcagtCagtttgcagcaaggttgggt	12	9	4	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:91873723C>A	uc004efk.1	+	7	4673	c.3828C>A	c.(3826-3828)GTC>GTA	p.V1276V	PCDH11X_uc004efl.1_Silent_p.V1266V|PCDH11X_uc004efo.1_Silent_p.V1239V|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Silent_p.V1268V|PCDH11X_uc004efn.1_Silent_p.V1258V	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1276	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						AATCATCAGTCAGTTTGCAGC	0.517													A	91873723	A	A	91873723	2	1	265	1	0	0	0	0	0	0	0	1	11508	813	29	5		5	PCDH11X	23	91873723	Silent	SNP	C	TCGA-76-4935-01A-01D-1486-08	26054319	91873723	63396837	65	19052											
CSTF2	1478	broad.mit.edu	37	chrX	100075435	100075435	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttgactgtgagagacccagcGgtggatcgttctctacgttc	12	10	1	3			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:100075435G>T	uc004egh.2	+	1	88	c.30G>T	c.(28-30)GCG>GCT	p.A10A	CSTF2_uc010nnd.2_Silent_p.A10A|CSTF2_uc004egi.2_Silent_p.A10A	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	10					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						GAGACCCAGCGGTGGATCGTT	0.562													T	100075435	T	T	100075435	2	4	265	1	0	0	0	0	0	0	0	1	3984	1103	39	5		5	CSTF2	23	100075435	Silent	SNP	G	TCGA-76-4935-01A-01D-1486-08	8201712	100075435	55195125	66	19053											
TEX13B	56156	broad.mit.edu	37	chrX	107224498	107224498	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ccaagcccagagaagacagaCatggctgtttgtactgacct	10	11	0	4			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:107224498C>G	uc004enn.1	-	3	844	c.751G>C	c.(751-753)GTC>CTC	p.V251L		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	251										ovary(1)	1						AGAAGACAGACATGGCTGTTT	0.552													G	107224498	G	G	107224498	3	3	265	1	0	0	0	0	1	0	0	0	15774	478	17	5	191	5	TEX13B	23	107224498	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	7149063	107224498	48046062	67	19054											
TRPC5	7224	broad.mit.edu	37	chrX	111020072	111020072	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ttgcagcctaaattaaaagaGacactcttggatttggcccg	9	9	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:111020072G>A	uc004epl.1	-	11	3310	c.2391C>T	c.(2389-2391)GTC>GTT	p.V797V		NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	797	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						AATTAAAAGAGACACTCTTGG	0.483													A	111020072	A	A	111020072	2	1	265	1	0	0	0	0	0	0	0	1	16579	929	33	3		3	TRPC5	23	111020072	Silent	SNP	G	TCGA-76-4935-01A-01D-1486-08	3795574	111020072	44250488	68	19055											
AFF2	2334	broad.mit.edu	37	chrX	148059892	148059892	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctttcctcatcaccacagCtaccgatgtttatcactcct	4	16	3	0			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:148059892C>T	uc004fcp.2	+	18	3956	c.3477C>T	c.(3475-3477)TGC>TGT	p.C1159C	AFF2_uc004fcq.2_Silent_p.C1149C|AFF2_uc004fcr.2_Silent_p.C1120C|AFF2_uc011mxb.1_Silent_p.C1124C|AFF2_uc004fcs.2_Silent_p.C1124C|AFF2_uc011mxc.1_Silent_p.C800C	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1159					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ATCACCACAGCTACCGATGTT	0.378													T	148059892	T	T	148059892	2	4	265	1	0	0	0	0	0	0	0	1	357	811	28	3		3	AFF2	23	148059892	Silent	SNP	C	TCGA-76-4935-01A-01D-1486-08	37039820	148059892	7210668	69	19056											
MTMR1	8776	broad.mit.edu	37	chrX	149931076	149931076	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	ctcaaggagctgctggccgtCagggcggagctgcagaagcg	17	11	2	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:149931076C>A	uc004fei.2	+	15	2007	c.1872C>A	c.(1870-1872)GTC>GTA	p.V624V	MTMR1_uc011mya.1_Silent_p.V530V|MTMR1_uc004feh.1_Silent_p.V632V|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_Intron	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	624						plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TGCTGGCCGTCAGGGCGGAGC	0.627													A	149931076	A	A	149931076	2	1	265	1	0	0	0	0	0	0	0	1	9938	813	29	5		5	MTMR1	23	149931076	Silent	SNP	C	TCGA-76-4935-01A-01D-1486-08	1871184	149931076	5339484	70	19057											
ABCD1	215	broad.mit.edu	37	chrX	153008746	153008746	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaaggcaagatcttccaggCggccaaggacgcgggcattg	16	10	1	1			TCGA-76-4935-01A-01D-1486-08	TCGA-76-4935-10A-01D-1486-08									Somatic	Phase_I	Capture				Illumina GAIIx	c8d06abf-437d-4bc9-804b-44345af74f36	7acdfba8-5a3c-4192-923e-1b0c6a34cf91	g.chrX:153008746C>T	uc004fif.2	+	9	2336	c.1937C>T	c.(1936-1938)GCG>GTG	p.A646V	ABCD1_uc004fig.2_Missense_Mutation_p.A146V|ABCD1_uc004fih.2_RNA	NM_000033	NP_000024	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member	646	ABC transporter.		A -> P (in X-ALD).		fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ATCTTCCAGGCGGCCAAGGAC	0.672													T	153008746	T	T	153008746	3	4	265	1	0	0	0	0	1	0	0	0	60	768	27	1	1971	1	ABCD1	23	153008746	Missense_Mutation	SNP	C	TCGA-76-4935-01A-01D-1486-08	3077670	153008746	2261814	71	19058											
GJA5	2702	broad.mit.edu	37	chr1	147230396	147230396	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggcacctcaggcttctggccAtaacgaacctggatgaaacc	10	13	2	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr1:147230396A>G	uc001eps.1	-	2	1092	c.951T>C	c.(949-951)TAT>TAC	p.Y317Y	GJA5_uc001ept.1_Silent_p.Y317Y	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	317	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			GCTTCTGGCCATAACGAACCT	0.542													G	147230396	G	G	147230396	2	3	266	1	0	0	0	0	0	0	0	1	6404	224	8	4		4	GJA5	1	147230396	Silent	SNP	A	TCGA-76-6191-01A-12D-1696-08		147230396	102020225	1	19059											
KPRP	448834	broad.mit.edu	37	chr1	152732251	152732251	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgccaggtgtcagaccagGctccatgccagtctcagacc	10	14	2	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr1:152732251G>A	uc001fal.1	+	2	245	c.187G>A	c.(187-189)GCT>ACT	p.A63T		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	63	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCAGACCAGGCTCCATGCCA	0.552													A	152732251	A	A	152732251	3	1	266	1	0	0	0	0	1	0	0	0	8436	1203	42	3	189	3	KPRP	1	152732251	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	5501855	152732251	96518370	2	19060											
METTL13	51603	broad.mit.edu	37	chr1	171765699	171765699	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctgggctcaaggcagtgttcCccctcctatatgtccggcga	11	14	1	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr1:171765699C>A	uc001ghz.2	+	8	2250	c.1903C>A	c.(1903-1905)CCC>ACC	p.P635T	METTL13_uc001gia.2_Missense_Mutation_p.P549T|METTL13_uc001gib.2_Missense_Mutation_p.P479T|METTL13_uc010pml.1_Missense_Mutation_p.P634T|METTL13_uc001gic.1_RNA	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	635							methyltransferase activity|protein binding			kidney(1)	1						GGCAGTGTTCCCCCTCCTATA	0.498													A	171765699	A	A	171765699	3	1	266	1	0	0	0	0	1	0	0	0	9497	623	22	5	1933	5	METTL13	1	171765699	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	19033448	171765699	77484922	3	19061											
TPR	7175	broad.mit.edu	37	chr1	186289465	186289465	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccttgagaagcaagctggcCaagatcagagtgactagaac	11	9	1	5			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr1:186289465C>T	uc001grv.2	-	46	6844	c.6547G>A	c.(6547-6549)GGC>AGC	p.G2183S		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	2183					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GCAAGCTGGCCAAGATCAGAG	0.418			T	NTRK1	papillary thyroid								T	186289465	T	T	186289465	3	4	266	1	0	0	0	0	1	0	0	0	16413	594	21	3	568	3	TPR	1	186289465	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	14523766	186289465	62961156	4	19062											
KCNJ3	3760	broad.mit.edu	37	chr2	155711520	155711520	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	atattactacaaaactaccaTctaagctgcagaaaattact	3	9	1	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr2:155711520T>A	uc002tyv.1	+	3	1396	c.1201T>A	c.(1201-1203)TCT>ACT	p.S401T	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	401	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	AAAACTACCATCTAAGCTGCA	0.398													A	155711520	A	A	155711520	3	1	266	1	0	0	0	0	1	0	0	0	8052	1435	50	5	1211	5	KCNJ3	2	155711520	Missense_Mutation	SNP	T	TCGA-76-6191-01A-12D-1696-08		155711520	87487853	5	19063											
LRP2	4036	broad.mit.edu	37	chr2	170003375	170003375	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agaaaggccagttggccaacCaaggtcctcgaaaaccagga	11	11	0	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr2:170003375C>A	uc002ues.2	-	69	12898	c.12685G>T	c.(12685-12687)GGT>TGT	p.G4229C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4229	LDL-receptor class B 36.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTTGGCCAACCAAGGTCCTCG	0.448													A	170003375	A	A	170003375	3	1	266	1	0	0	0	0	1	0	0	0	8956	594	21	5	1326	5	LRP2	2	170003375	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	14291855	170003375	73195998	6	19064											
TTC30A	92104	broad.mit.edu	37	chr2	178482747	178482747	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaagccctcggtggtcatgCccacacctagctcaggatgc	10	15	2	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr2:178482747C>T	uc002ulo.2	-	1	948	c.683G>A	c.(682-684)GGC>GAC	p.G228D		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	228					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			GGTGGTCATGCCCACACCTAG	0.527													T	178482747	T	T	178482747	3	4	266	1	0	0	0	0	1	0	0	0	16695	739	26	3	1318	3	TTC30A	2	178482747	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	8479372	178482747	64716626	7	19065											
PLCL2	23228	broad.mit.edu	37	chr3	17053527	17053527	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ataaaaggggcctttctgtgAgaaaagggaagaaatccagg	13	5	1	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr3:17053527A>G	uc011awc.1	+	5	2770	c.2665A>G	c.(2665-2667)AGA>GGA	p.R889G	PLCL2_uc011awd.1_Missense_Mutation_p.R771G	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	897					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						CCTTTCTGTGAGAAAAGGGAA	0.463													G	17053527	G	G	17053527	3	3	266	1	0	0	0	0	1	0	0	0	12040	296	11	4	2689	4	PLCL2	3	17053527	Missense_Mutation	SNP	A	TCGA-76-6191-01A-12D-1696-08		17053527	180968903	8	19066											
TRAK1	22906	broad.mit.edu	37	chr3	42167078	42167078	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aacattgacctcacaaccgaGcaaattgaagagacgttaaa	7	9	1	3			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr3:42167078G>A	uc003cky.2	+	2	474	c.258G>A	c.(256-258)GAG>GAA	p.E86E	TRAK1_uc011azh.1_Silent_p.E86E|TRAK1_uc011azi.1_Silent_p.E86E	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	86	HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TCACAACCGAGCAAATTGAAG	0.443													A	42167078	A	A	42167078	2	1	266	1	0	0	0	0	0	0	0	1	16446	962	34	3		3	TRAK1	3	42167078	Silent	SNP	G	TCGA-76-6191-01A-12D-1696-08	25113551	42167078	155855352	9	19067											
OR5H1	26341	broad.mit.edu	37	chr3	97852415	97852415	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	taaatcctatcatctacagtCtgagaaataagcaagtcaca	5	9	4	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr3:97852415C>T	uc011bgt.1	+	1	874	c.874C>T	c.(874-876)CTG>TTG	p.L292L		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						CATCTACAGTCTGAGAAATAA	0.348													T	97852415	T	T	97852415	2	4	266	1	0	0	0	0	0	0	0	1	11159	912	32	3		3	OR5H1	3	97852415	Silent	SNP	C	TCGA-76-6191-01A-12D-1696-08	55685337	97852415	100170015	10	19068											
OR5K1	26339	broad.mit.edu	37	chr3	98189045	98189045	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tctcaggttcagttcaagtcTttaccataggtagtgtctta	8	8	5	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr3:98189045T>A	uc003dsm.2	+	1	625	c.625T>A	c.(625-627)TTT>ATT	p.F209I		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						AGTTCAAGTCTTTACCATAGG	0.353													A	98189045	A	A	98189045	3	1	266	1	0	0	0	0	1	0	0	0	11166	1609	56	5	627	5	OR5K1	3	98189045	Missense_Mutation	SNP	T	TCGA-76-6191-01A-12D-1696-08	336630	98189045	99833385	11	19069											
EHHADH	1962	broad.mit.edu	37	chr3	184910535	184910535	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcctattacccctttttcGggcaggagttcctggaagca	9	13	0	0	rs138388673	byFrequency	TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr3:184910535G>A	uc003fpf.2	-	7	1678	c.1651C>T	c.(1651-1653)CGA>TGA	p.R551*	EHHADH_uc011brs.1_Nonsense_Mutation_p.R455*	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	551	3-hydroxyacyl-CoA dehydrogenase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	CCCCTTTTTCGGGCAGGAGTT	0.473													A	184910535	A	A	184910535	4	1	266	1	0	0	0	0	0	1	0	0	4982	1124	39	2	524	2	EHHADH	3	184910535	Nonsense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	86721490	184910535	13111895	12	19070											
RGS12	6002	broad.mit.edu	37	chr4	3319669	3319669	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagggtggagggcagcttcgCgcagcccccgctgaatgccc	15	15	0	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr4:3319669C>T	uc003ggw.2	+	2	2676	c.1772C>T	c.(1771-1773)GCG>GTG	p.A591V	RGS12_uc003ggu.2_Missense_Mutation_p.A591V|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Missense_Mutation_p.A591V|RGS12_uc003ggx.1_Missense_Mutation_p.A591V	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	591						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGCAGCTTCGCGCAGCCCCCG	0.577													T	3319669	T	T	3319669	3	4	266	1	0	0	0	0	1	0	0	0	13295	768	27	1	1774	1	RGS12	4	3319669	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08		3319669	187834607	13	19071											
AFM	173	broad.mit.edu	37	chr4	74367504	74367504	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ttgacatcttttggccacagGtttcttgtcaacttagtgaa	8	8	3	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr4:74367504G>C	uc003hhb.2	+	13	1678	c.1647G>C	c.(1645-1647)AGG>AGC	p.R549S		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	549	Albumin 3.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTGGCCACAGGTTTCTTGTCA	0.388													C	74367504	C	C	74367504	3	2	266	1	0	0	0	0	1	0	0	0	361	1275	44	5	1697	5	AFM	4	74367504	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	71047835	74367504	116786772	14	19072											
RXFP1	59350	broad.mit.edu	37	chr4	159554592	159554592	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taagattgaaaatcttccacCgcttatattcaaggacctga	6	9	2	3			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr4:159554592C>T	uc003ipz.2	+	12	1017	c.935C>T	c.(934-936)CCG>CTG	p.P312L	RXFP1_uc010iqj.1_Missense_Mutation_p.P141L|RXFP1_uc011cja.1_Missense_Mutation_p.P207L|RXFP1_uc010iqo.2_Intron|RXFP1_uc011cjb.1_Intron|RXFP1_uc010iqk.2_Missense_Mutation_p.P180L|RXFP1_uc011cjc.1_Missense_Mutation_p.P231L|RXFP1_uc011cjd.1_Missense_Mutation_p.P231L|RXFP1_uc010iql.2_Missense_Mutation_p.P156L|RXFP1_uc011cje.1_Missense_Mutation_p.P339L|RXFP1_uc010iqm.2_Missense_Mutation_p.P279L|RXFP1_uc011cjf.1_Missense_Mutation_p.P182L|RXFP1_uc010iqn.2_Missense_Mutation_p.P258L	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	312	Extracellular (Potential).|LRR 7.					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		AATCTTCCACCGCTTATATTC	0.284													T	159554592	T	T	159554592	3	4	266	1	0	0	0	0	1	0	0	0	13759	652	23	2	981	2	RXFP1	4	159554592	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	85187088	159554592	31599684	15	19073											
SPOCK3	50859	broad.mit.edu	37	chr4	167663205	167663205	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gctgagctcagtctggcaagGtgggtctgcaatgacattaa	13	8	3	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr4:167663205G>T	uc003iri.1	-	10	1087	c.946C>A	c.(946-948)CCT>ACT	p.P316T	SPOCK3_uc011cjp.1_Missense_Mutation_p.P273T|SPOCK3_uc011cjq.1_Missense_Mutation_p.P325T|SPOCK3_uc011cjr.1_Missense_Mutation_p.P196T|SPOCK3_uc003irj.1_Missense_Mutation_p.P313T|SPOCK3_uc011cjs.1_Missense_Mutation_p.P265T|SPOCK3_uc011cjt.1_Missense_Mutation_p.P224T|SPOCK3_uc011cju.1_Missense_Mutation_p.P209T|SPOCK3_uc011cjv.1_Missense_Mutation_p.P218T	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	316	Thyroglobulin type-1.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		GTCTGGCAAGGTGGGTCTGCA	0.373													T	167663205	T	T	167663205	3	4	266	1	0	0	0	0	1	0	0	0	15080	1261	44	5	376	5	SPOCK3	4	167663205	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	8108613	167663205	23491071	16	19074											
NMUR2	56923	broad.mit.edu	37	chr5	151775094	151775094	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccacaaagctgaagaagagtCggtcaatgtggaacggggcc	14	9	1	3			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr5:151775094C>T	uc003luv.2	-	3	1029	c.863G>A	c.(862-864)CGA>CAA	p.R288Q		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	288	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GAAGAAGAGTCGGTCAATGTG	0.483													T	151775094	T	T	151775094	3	4	266	1	0	0	0	0	1	0	0	0	10507	884	31	2	392	2	NMUR2	5	151775094	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08		151775094	29140166	17	19075											
DDAH2	23564	broad.mit.edu	37	chr6	31696723	31696723	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gccgtgtcgccaagcagcggTcccagcggcaatgactcctc	12	16	0	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr6:31696723T>C	uc003nwp.2	-	1	847	c.216A>G	c.(214-216)GGA>GGG	p.G72G	DDAH2_uc003nwq.2_Silent_p.G72G	NM_013974	NP_039268	O95865	DDAH2_HUMAN	dimethylarginine dimethylaminohydrolase 2	72					anti-apoptosis|arginine catabolic process|citrulline metabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction	cytoplasm	dimethylargininase activity|protein binding				0					L-Citrulline(DB00155)	CAAGCAGCGGTCCCAGCGGCA	0.662													C	31696723	C	C	31696723	2	2	266	1	0	0	0	0	0	0	0	1	4322	1654	58	4		4	DDAH2	6	31696723	Silent	SNP	T	TCGA-76-6191-01A-12D-1696-08		31696723	139418344	18	19076											
LPA	4018	broad.mit.edu	37	chr6	161007524	161007524	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cttggaactgggaccaccgtGggagttgtgaggagagttga	17	6	0	3			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr6:161007524G>T	uc003qtl.2	-	26	4206	c.4086C>A	c.(4084-4086)CCC>CCA	p.P1362P		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3870	Kringle 34.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGACCACCGTGGGAGTTGTGA	0.498													T	161007524	T	T	161007524	2	4	266	1	0	0	0	0	0	0	0	1	8903	1335	47	5		5	LPA	6	161007524	Silent	SNP	G	TCGA-76-6191-01A-12D-1696-08	129310801	161007524	10107543	19	19077											
CCR6	1235	broad.mit.edu	37	chr6	167549965	167549965	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggccaggtctatgacagacGtctatctcttgaacatggcc	10	11	3	3	rs76452893	by1000genomes	TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr6:167549965G>A	uc003qvl.2	+	13	2723	c.247G>A	c.(247-249)GTC>ATC	p.V83I	CCR6_uc010kkm.2_Missense_Mutation_p.V83I|CCR6_uc003qvn.3_Missense_Mutation_p.V83I|CCR6_uc003qvm.3_Missense_Mutation_p.V83I	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	83	Cytoplasmic (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		TATGACAGACGTCTATCTCTT	0.488													A	167549965	A	A	167549965	3	1	266	1	0	0	0	0	1	0	0	0	2945	1145	40	1	253	1	CCR6	6	167549965	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	6542441	167549965	3565102	20	19078											
USP42	84132	broad.mit.edu	37	chr7	6189342	6189342	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcagcttctgtccaaaactgGtcagttaataggtcctcagt	8	10	4	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr7:6189342G>T	uc011jwo.1	+	13	1638	c.1515G>T	c.(1513-1515)TGG>TGT	p.W505C	USP42_uc010kth.1_Missense_Mutation_p.W438C|USP42_uc011jwp.1_Missense_Mutation_p.W505C|USP42_uc011jwq.1_Missense_Mutation_p.W312C|USP42_uc011jwr.1_Missense_Mutation_p.W350C	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	505					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		TCCAAAACTGGTCAGTTAATA	0.443													T	6189342	T	T	6189342	3	4	266	1	0	0	0	0	1	0	0	0	17070	1270	44	5	1561	5	USP42	7	6189342	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08		6189342	152949321	21	19079											
SKAP2	8935	broad.mit.edu	37	chr7	26779515	26779515	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcagtttaccttttctgcGtttttcaaggtagccagcct	7	11	3	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr7:26779515G>A	uc003syc.2	-	5	669	c.376C>T	c.(376-378)CGC>TGC	p.R126C	SKAP2_uc011jzi.1_Translation_Start_Site|SKAP2_uc011jzj.1_Missense_Mutation_p.R111C	NM_003930	NP_003921	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	126	PH.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			pancreas(1)	1						CCTTTTCTGCGTTTTTCAAGG	0.373													A	26779515	A	A	26779515	3	1	266	1	0	0	0	0	1	0	0	0	14356	1145	40	1	735	1	SKAP2	7	26779515	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	20590173	26779515	132359148	22	19080											
EGFR	1956	broad.mit.edu	37	chr7	55233110	55233110	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggccatgtgtgccacctgtgCcatccaaactgcacctacgg	10	15	0	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr7:55233110C>G	uc003tqk.2	+	15	2106	c.1860C>G	c.(1858-1860)TGC>TGG	p.C620W	EGFR_uc003tqi.2_Missense_Mutation_p.C620W|EGFR_uc003tqj.2_Missense_Mutation_p.C620W|EGFR_uc010kzg.1_Missense_Mutation_p.C575W|EGFR_uc011kco.1_Missense_Mutation_p.C567W|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_RNA|EGFR_uc003tqn.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	620	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.C620Y(1)|p.C620W(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GCCACCTGTGCCATCCAAACT	0.542		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			G	55233110	G	G	55233110	3	3	266	1	0	0	0	0	1	0	0	0	4967	747	26	5	1929	5	EGFR	7	55233110	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	28453595	55233110	103905553	23	19081											
CCDC132	55610	broad.mit.edu	37	chr7	92932809	92932809	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgagaatgttcttagagaatGagacttgggaactttgtcct	11	5	1	3			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr7:92932809G>C	uc003umo.2	+	17	1527	c.1399G>C	c.(1399-1401)GAG>CAG	p.E467Q	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.E437Q|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.E187Q	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	467											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			CTTAGAGAATGAGACTTGGGA	0.343													C	92932809	C	C	92932809	3	2	266	1	0	0	0	0	1	0	0	0	2767	1291	45	5	1507	5	CCDC132	7	92932809	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	37699699	92932809	66205854	24	19082											
TRRAP	8295	broad.mit.edu	37	chr7	98547126	98547126	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcaccctgctgctgccgggGggtgcccagacggctgtgcg	16	14	1	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr7:98547126G>A	uc003upp.2	+	35	5063	c.4854G>A	c.(4852-4854)GGG>GGA	p.G1618G	TRRAP_uc011kis.1_Silent_p.G1600G|TRRAP_uc003upr.2_Silent_p.G1317G	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1618					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGCTGCCGGGGGGTGCCCAGA	0.617													A	98547126	A	A	98547126	2	1	266	1	0	0	0	0	0	0	0	1	16598	1219	43	3		3	TRRAP	7	98547126	Silent	SNP	G	TCGA-76-6191-01A-12D-1696-08	5614317	98547126	60591537	25	19083											
CUL1	8454	broad.mit.edu	37	chr7	148495685	148495685	+	Frame_Shift_Del	DEL	C	-	-													aagaaattaagggttaacatCaatgtgccaatgaaaaccga							TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr7:148495685delC	uc010lpg.2	+	20	2578	c.2052delC	c.(2050-2052)ATCfs	p.I684fs	CUL1_uc003wey.2_Frame_Shift_Del_p.I684fs|CUL1_uc003wez.2_Frame_Shift_Del_p.I574fs|CUL1_uc003wfa.2_Frame_Shift_Del_p.I345fs	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	684					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GGGTTAACATCAATGTGCCAA	0.373													-	148495685	-	-	148495685	7	5	266	1	0	1	0	1	0	0	0	0	4054	816	29	0	2126	0	CUL1	7	148495685	Frame_Shift_Del	DEL	C	TCGA-76-6191-01A-12D-1696-08	49948559	148495685	10642978	26	19084											
SOX7	83595	broad.mit.edu	37	chr8	10583718	10583718	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctggcaggtgggggatgcGgcggggatggccatgctcct	19	11	0	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr8:10583718G>A	uc003wtf.2	-	2	776	c.697C>T	c.(697-699)CGC>TGC	p.R233C	SOX7_uc011kwz.1_Missense_Mutation_p.R285C	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	233					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		TGGGGGATGCGGCGGGGATGG	0.692													A	10583718	A	A	10583718	3	1	266	1	0	0	0	0	1	0	0	0	14956	1116	39	2	473	2	SOX7	8	10583718	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08		10583718	135780304	27	19085											
DOK2	9046	broad.mit.edu	37	chr8	21767417	21767417	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctctccagagacgcagcgaCggcctgcctcaaaggaaaag	11	14	2	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr8:21767417C>T	uc003wzy.1	-	5	737	c.644G>A	c.(643-645)CGT>CAT	p.R215H	DOK2_uc003wzx.1_Missense_Mutation_p.R215H|DOK2_uc003wzz.1_Missense_Mutation_p.R61H|DOK2_uc010lth.1_Missense_Mutation_p.R61H	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	215	IRS-type PTB.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GACGCAGCGACGGCCTGCCTC	0.502													T	21767417	T	T	21767417	3	4	266	1	0	0	0	0	1	0	0	0	4697	536	19	1	598	1	DOK2	8	21767417	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	11183699	21767417	124596605	28	19086											
KCNU1	157855	broad.mit.edu	37	chr8	36642023	36642023	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agcattcattctctcttcctTtgtgaccttcttcagtggac	6	12	5	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr8:36642023T>C	uc010lvw.2	+	1	182	c.95T>C	c.(94-96)TTT>TCT	p.F32S	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	32	Helical; Name=Segment S0; (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CTCTCTTCCTTTGTGACCTTC	0.413													C	36642023	C	C	36642023	3	2	266	1	0	0	0	0	1	0	0	0	8093	1841	64	4	97	4	KCNU1	8	36642023	Missense_Mutation	SNP	T	TCGA-76-6191-01A-12D-1696-08	14874606	36642023	109721999	29	19087											
ZFAND1	79752	broad.mit.edu	37	chr8	82626245	82626245	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atttttggcacctttccatcGtttacttgctgtttctcctg	6	11	1	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr8:82626245G>A	uc003ycj.1	-	6	402	c.388C>T	c.(388-390)CGA>TGA	p.R130*	ZFAND1_uc010lzx.1_Nonsense_Mutation_p.R130*|ZFAND1_uc003yck.1_Nonsense_Mutation_p.R23*	NM_024699	NP_078975	Q8TCF1	ZFAN1_HUMAN	zinc finger, AN1-type domain 1	130							zinc ion binding	p.R130*(1)		ovary(1)	1						CCTTTCCATCGTTTACTTGCT	0.343													A	82626245	A	A	82626245	4	1	266	1	0	0	0	0	0	1	0	0	17623	1153	40	1	478	1	ZFAND1	8	82626245	Nonsense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	45984222	82626245	63737777	30	19088											
ANKRD46	157567	broad.mit.edu	37	chr8	101541822	101541823	+	Frame_Shift_Del	DEL	TG	-	-													tggccacagaggtgaagagcTgtgtttccttgataatctgt							TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr8:101541822_101541823delTG	uc003yjm.2	-	3	443_444	c.239_240delCA	c.(238-240)ACAfs	p.T80fs	ANKRD46_uc003yjn.1_Frame_Shift_Del_p.T80fs|ANKRD46_uc003yjo.1_Frame_Shift_Del_p.T80fs|ANKRD46_uc003yjp.1_Frame_Shift_Del_p.T80fs	NM_198401	NP_940683	Q86W74	ANR46_HUMAN	ankyrin repeat domain 46	80	ANK 3.					integral to membrane					0	all_cancers(14;5.07e-05)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000353)|all_lung(17;0.000998)		Epithelial(11;2.61e-11)|all cancers(13;5.03e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.49e-06)|STAD - Stomach adenocarcinoma(118;0.0957)			GGTGAAGAGCTGTGTTTCCTTG	0.436													-	101541823	-	-	101541822	7	5	266	1	0	1	0	1	0	0	0	0	674	1567	55	0	458	0	ANKRD46	8	101541822	Frame_Shift_Del	DEL	TG	TCGA-76-6191-01A-12D-1696-08	18915577	101541822	44822200	31	19089											
GRIN3A	116443	broad.mit.edu	37	chr9	104335628	104335628	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctttcccattggtggtcCgcaaggcagggagctctctt	12	12	1	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr9:104335628C>T	uc004bbp.1	-	9	3777	c.3176G>A	c.(3175-3177)CGG>CAG	p.R1059Q	GRIN3A_uc004bbo.1_Missense_Mutation_p.R134Q	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	1059	Cytoplasmic (Potential).|Potential.				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ATTGGTGGTCCGCAAGGCAGG	0.527													T	104335628	T	T	104335628	3	4	266	1	0	0	0	0	1	0	0	0	6783	652	23	2	175	2	GRIN3A	9	104335628	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08		104335628	36877803	32	19090											
DBC1	1620	broad.mit.edu	37	chr9	122000991	122000991	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acggaactcacagagtccagAttgtcatagctgttacagcc	9	11	2	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr9:122000991A>G	uc004bkc.2	-	5	1083	c.627T>C	c.(625-627)AAT>AAC	p.N209N	DBC1_uc004bkd.2_Silent_p.N209N	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	209	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CAGAGTCCAGATTGTCATAGC	0.507													G	122000991	G	G	122000991	2	3	266	1	0	0	0	0	0	0	0	1	4247	330	12	4		4	DBC1	9	122000991	Silent	SNP	A	TCGA-76-6191-01A-12D-1696-08	17665363	122000991	19212440	33	19091											
PTEN	5728	broad.mit.edu	37	chr10	89624299	89624299	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aggatggattcgacttagacTtgacctgtatccatttctgc	9	9	1	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr10:89624299T>G	uc001kfb.2	+	2	1104	c.73T>G	c.(73-75)TTG>GTG	p.L25V	KILLIN_uc009xti.2_5'Flank	NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	25	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(13)|p.0?(12)|p.L25F(2)|p.D24_L25del(1)|p.L25fs*28(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CGACTTAGACTTGACCTGTAT	0.463		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			G	89624299	G	G	89624299	3	3	266	1	0	0	0	0	1	0	0	0	12738	1606	56	5	75	5	PTEN	10	89624299	Missense_Mutation	SNP	T	TCGA-76-6191-01A-12D-1696-08		89624299	45910448	34	19092											
TSPAN32	10077	broad.mit.edu	37	chr11	2334954	2334954	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaaggtacgtcccacgtccGgcggcaggagctggcggcca	16	13	0	0	rs138129469		TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr11:2334954G>A	uc001lvy.1	+	5	562	c.425G>A	c.(424-426)CGG>CAG	p.R142Q	TSPAN32_uc001lvx.1_Intron|TSPAN32_uc009ydk.1_Missense_Mutation_p.R152Q|TSPAN32_uc010qxk.1_Missense_Mutation_p.R177Q|TSPAN32_uc009ydl.1_RNA|TSPAN32_uc001lvz.1_Missense_Mutation_p.R112Q|TSPAN32_uc001lwb.1_Missense_Mutation_p.R112Q|TSPAN32_uc001lwc.1_Missense_Mutation_p.R87Q|TSPAN32_uc001lwd.1_5'Flank	NM_139022	NP_620591	Q96QS1	TSN32_HUMAN	tumor-suppressing subtransferable candidate 6	142					cell-cell signaling	integral to membrane				central_nervous_system(1)	1		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		TCCCACGTCCGGCGGCAGGAG	0.647													A	2334954	A	A	2334954	3	1	266	1	0	0	0	0	1	0	0	0	16644	1116	39	2	443	2	TSPAN32	11	2334954	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08		2334954	132671562	35	19093											
OR52R1	119695	broad.mit.edu	37	chr11	4825512	4825512	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcatacgtggcacagaaCggaaaggcaatccacaactg	10	11	0	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr11:4825512C>T	uc010qym.1	-	1	336	c.336G>A	c.(334-336)CCG>CCA	p.P112P		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCACAGAACGGAAAGGCAA	0.512													T	4825512	T	T	4825512	2	4	266	1	0	0	0	0	0	0	0	1	11131	523	19	1		1	OR52R1	11	4825512	Silent	SNP	C	TCGA-76-6191-01A-12D-1696-08	2490558	4825512	130181004	36	19094											
OR5D14	219436	broad.mit.edu	37	chr11	55563722	55563722	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtgactgtactaaaaatcCgttctgttagtgggcgccac	10	9	1	1	rs143761060		TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr11:55563722C>T	uc010rim.1	+	1	691	c.691C>T	c.(691-693)CGT>TGT	p.R231C		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				ACTAAAAATCCGTTCTGTTAG	0.473													T	55563722	T	T	55563722	3	4	266	1	0	0	0	0	1	0	0	0	11155	652	23	2	693	2	OR5D14	11	55563722	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	50738210	55563722	79442794	37	19095											
MS4A6E	245802	broad.mit.edu	37	chr11	60102450	60102450	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctcccaagcagagaaacccGaacccaccaaccaggggcag	9	16	1	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr11:60102450G>A	uc001npd.2	+	1	96	c.82G>A	c.(82-84)GAA>AAA	p.E28K		NM_139249	NP_640342	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member	28	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						AGAGAAACCCGAACCCACCAA	0.443													A	60102450	A	A	60102450	3	1	266	1	0	0	0	0	1	0	0	0	9865	1059	37	2	84	2	MS4A6E	11	60102450	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	4538728	60102450	74904066	38	19096											
MS4A14	84689	broad.mit.edu	37	chr11	60183031	60183031	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatgattcaacaacaaatgCacaatctgttatctttggag	7	7	3	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr11:60183031C>T	uc001npj.2	+	5	1155	c.590C>T	c.(589-591)GCA>GTA	p.A197V	MS4A14_uc001npi.2_Missense_Mutation_p.A85V|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.A180V|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	197						integral to membrane	receptor activity			breast(1)	1						ACAACAAATGCACAATCTGTT	0.378													T	60183031	T	T	60183031	3	4	266	1	0	0	0	0	1	0	0	0	9858	710	25	3	608	3	MS4A14	11	60183031	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	80581	60183031	74823485	39	19097											
MS4A12	54860	broad.mit.edu	37	chr11	60271232	60271232	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttggccttcattggagtgaTtctgctgctggtggatatgt	13	7	2	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr11:60271232T>C	uc001npr.2	+	5	587	c.530T>C	c.(529-531)ATT>ACT	p.I177T		NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member	177	Helical; (Potential).					integral to membrane	receptor activity				0						ATTGGAGTGATTCTGCTGCTG	0.458													C	60271232	C	C	60271232	3	2	266	1	0	0	0	0	1	0	0	0	9856	1493	52	4	544	4	MS4A12	11	60271232	Missense_Mutation	SNP	T	TCGA-76-6191-01A-12D-1696-08	88201	60271232	74735284	40	19098											
PPFIA1	8500	broad.mit.edu	37	chr11	70181755	70181755	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttcagaatctaatgagagGcttcaacttcatcttaaaga	6	8	5	3			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr11:70181755G>A	uc001opo.2	+	11	1581	c.1383G>A	c.(1381-1383)AGG>AGA	p.R461R	PPFIA1_uc001opn.1_Silent_p.R461R|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	461	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CTAATGAGAGGCTTCAACTTC	0.403													A	70181755	A	A	70181755	2	1	266	1	0	0	0	0	0	0	0	1	12309	1194	42	3		3	PPFIA1	11	70181755	Silent	SNP	G	TCGA-76-6191-01A-12D-1696-08	9910523	70181755	64824761	41	19099											
CADM1	23705	broad.mit.edu	37	chr11	115111056	115111056	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtagctgaatcacagagtcgTcactcttattgacttggcaa	9	9	3	3			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr11:115111056T>A	uc001ppi.3	-	2	338	c.209A>T	c.(208-210)GAC>GTC	p.D70V	CADM1_uc001ppf.3_Missense_Mutation_p.D70V|CADM1_uc001ppk.3_Missense_Mutation_p.D70V|CADM1_uc001ppj.3_Missense_Mutation_p.D70V|CADM1_uc001ppl.2_Missense_Mutation_p.D70V	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	70	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		CACAGAGTCGTCACTCTTATT	0.443													A	115111056	A	A	115111056	3	1	266	1	0	0	0	0	1	0	0	0	2566	1667	58	5	1155	5	CADM1	11	115111056	Missense_Mutation	SNP	T	TCGA-76-6191-01A-12D-1696-08	44929301	115111056	19895460	42	19100											
CHEK1	1111	broad.mit.edu	37	chr11	125503132	125503132	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtgagcgtttgttgaacaagAtgtgtggtactttaccatat	11	5	0	3			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr11:125503132A>T	uc009zbo.2	+	6	1391	c.499A>T	c.(499-501)ATG>TTG	p.M167L	CHEK1_uc010sbh.1_Missense_Mutation_p.M183L|CHEK1_uc010sbi.1_Missense_Mutation_p.M167L|CHEK1_uc001qcf.3_Missense_Mutation_p.M167L|CHEK1_uc009zbp.2_Missense_Mutation_p.M167L|CHEK1_uc001qcg.3_Missense_Mutation_p.M167L|CHEK1_uc009zbq.2_Missense_Mutation_p.M167L|CHEK1_uc001qci.1_RNA	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	167	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		GTTGAACAAGATGTGTGGTAC	0.378								Other_conserved_DNA_damage_response_genes					T	125503132	T	T	125503132	3	4	266	1	0	0	0	0	1	0	0	0	3334	333	12	5	517	5	CHEK1	11	125503132	Missense_Mutation	SNP	A	TCGA-76-6191-01A-12D-1696-08	10392076	125503132	9503384	43	19101											
PLCZ1	89869	broad.mit.edu	37	chr12	18836249	18836249	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctggaaaacagaggaataCgacgataacctgcaaaagga	10	7	1	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr12:18836249C>T	uc010sid.1	-	15	1942	c.1751G>A	c.(1750-1752)CGT>CAT	p.R584H	PLCZ1_uc001rdv.3_Missense_Mutation_p.R480H|PLCZ1_uc001rdw.3_Missense_Mutation_p.R325H|PLCZ1_uc001rdu.1_Missense_Mutation_p.R366H|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	584					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.R584C(1)		ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CAGAGGAATACGACGATAACC	0.378													T	18836249	T	T	18836249	3	4	266	1	0	0	0	0	1	0	0	0	12044	536	19	1	79	1	PLCZ1	12	18836249	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08		18836249	115015646	44	19102											
OR6C75	390323	broad.mit.edu	37	chr12	55758922	55758922	+	Frame_Shift_Del	DEL	T	-	-													attccacagcagtaacagacTttattcttcttggattgaca							TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr12:55758922delT	uc010spk.1	+	1	28	c.28delT	c.(28-30)TTTfs	p.F10fs		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						AGTAACAGACTTTATTCTTCT	0.353													-	55758922	-	-	55758922	7	5	266	1	0	1	0	1	0	0	0	0	11199	1609	56	0	30	0	OR6C75	12	55758922	Frame_Shift_Del	DEL	T	TCGA-76-6191-01A-12D-1696-08	36922673	55758922	78092973	45	19103											
EP400	57634	broad.mit.edu	37	chr12	132491424	132491424	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacctagcttgtaacgaaggTaagagtttgctagttttttt	9	6	0	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr12:132491424T>C	uc001ujn.2	+	14	3339	c.3304_splice	c.e14+2	p.G1102_splice	EP400_uc001ujl.2_Splice_Site_p.G1101_splice|EP400_uc001ujm.2_Splice_Site_p.G1102_splice	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400						histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GTAACGAAGGTAAGAGTTTGC	0.413													C	132491424	C	C	132491424	5	2	266	1	0	0	0	0	0	0	1	0	5149	1652	57	4	3357	4	EP400	12	132491424	Splice_Site	SNP	T	TCGA-76-6191-01A-12D-1696-08	76732502	132491424	1360471	46	19104											
EFHA1	221154	broad.mit.edu	37	chr13	22067477	22067477	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttccagtattcttgtatacTctgatgttgtggtacctgtt	8	8	2	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr13:22067477T>G	uc001uof.2	-	12	1238	c.1216A>C	c.(1216-1218)AGT>CGT	p.S406R	EFHA1_uc010tct.1_Missense_Mutation_p.S196R	NM_152726	NP_689939	Q8IYU8	EFHA1_HUMAN	EF-hand domain family, member A1	406							calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)		TCTTGTATACTCTGATGTTGT	0.318													G	22067477	G	G	22067477	3	3	266	1	0	0	0	0	1	0	0	0	4943	1551	54	5	92	5	EFHA1	13	22067477	Missense_Mutation	SNP	T	TCGA-76-6191-01A-12D-1696-08		22067477	93102401	47	19105											
MCF2L	23263	broad.mit.edu	37	chr13	113729315	113729315	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgggtggccgtccacaggtgGccgtggagagggcccgggcc	20	12	0	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr13:113729315G>T	uc001vsu.2	+	11	1313	c.1291G>T	c.(1291-1293)GCC>TCC	p.A431S	MCF2L_uc001vsq.2_Missense_Mutation_p.A431S|MCF2L_uc010tjr.1_Missense_Mutation_p.A374S|MCF2L_uc001vsr.2_Missense_Mutation_p.A378S|MCF2L_uc001vss.3_Missense_Mutation_p.A372S|MCF2L_uc010tjs.1_Missense_Mutation_p.A372S|MCF2L_uc001vst.1_Missense_Mutation_p.A336S	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	404	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TCCACAGGTGGCCGTGGAGAG	0.647													T	113729315	T	T	113729315	3	4	266	1	0	0	0	0	1	0	0	0	9379	1203	42	5	1428	5	MCF2L	13	113729315	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	91661838	113729315	1440563	48	19106											
KCNK10	54207	broad.mit.edu	37	chr14	88651963	88651963	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attccgttctccaactcagcGtgctgctggatacagtccgt	9	13	2	0	rs75132782	byFrequency	TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr14:88651963G>A	uc001xwo.2	-	7	1990	c.1533C>T	c.(1531-1533)CAC>CAT	p.H511H	KCNK10_uc001xwm.2_Silent_p.H516H|KCNK10_uc001xwn.2_Silent_p.H516H	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	511	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						CCAACTCAGCGTGCTGCTGGA	0.498													A	88651963	A	A	88651963	2	1	266	1	0	0	0	0	0	0	0	1	8059	1136	40	1		1	KCNK10	14	88651963	Silent	SNP	G	TCGA-76-6191-01A-12D-1696-08		88651963	18697577	49	19107											
FMN1	342184	broad.mit.edu	37	chr15	33359812	33359812	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaattttctcatcatttcCgaggtcaggtgaaacccgag	9	10	3	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr15:33359812C>T	uc001zhf.3	-	1	274	c.274G>A	c.(274-276)GGA>AGA	p.G92R	FMN1_uc001zhg.2_Missense_Mutation_p.G92R	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:Variant_position_missing_in_Q68DA7_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TCATCATTTCCGAGGTCAGGT	0.493													T	33359812	T	T	33359812	3	4	266	1	0	0	0	0	1	0	0	0	5949	661	23	2	3384	2	FMN1	15	33359812	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08		33359812	69171580	50	19108											
TGM5	9333	broad.mit.edu	37	chr15	43544994	43544994	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaaagacccagcattgcccGtagcgcacgggctggcagcc	13	15	0	1	rs138771869		TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr15:43544994G>A	uc001zrd.1	-	6	833	c.825C>T	c.(823-825)TAC>TAT	p.Y275Y	TGM5_uc001zre.1_Silent_p.Y193Y	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	275					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	AGCATTGCCCGTAGCGCACGG	0.587													A	43544994	A	A	43544994	2	1	266	1	0	0	0	0	0	0	0	1	15830	1140	40	1		1	TGM5	15	43544994	Silent	SNP	G	TCGA-76-6191-01A-12D-1696-08	10185182	43544994	58986398	51	19109											
LDHAL6B	92483	broad.mit.edu	37	chr15	59499582	59499582	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gattatcacagcaggtgcacGccaagaaaagggagaaacgc	12	9	1	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr15:59499582G>T	uc002agb.2	+	1	541	c.443G>T	c.(442-444)CGC>CTC	p.R148L	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	148		NAD (By similarity).			glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	GCAGGTGCACGCCAAGAAAAG	0.438													T	59499582	T	T	59499582	3	4	266	1	0	0	0	0	1	0	0	0	8700	1087	38	5	445	5	LDHAL6B	15	59499582	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	15954588	59499582	43031810	52	19110											
ZNF710	374655	broad.mit.edu	37	chr15	90610585	90610585	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctaccagctggcctgcaaCgggagggccttggaggagcc	16	12	1	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr15:90610585C>T	uc002bov.1	+	2	339	c.216C>T	c.(214-216)AAC>AAT	p.N72N		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	72					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			TGGCCTGCAACGGGAGGGCCT	0.711													T	90610585	T	T	90610585	2	4	266	1	0	0	0	0	0	0	0	1	18112	535	19	1		1	ZNF710	15	90610585	Silent	SNP	C	TCGA-76-6191-01A-12D-1696-08	31111003	90610585	11920807	53	19111											
C16orf59	80178	broad.mit.edu	37	chr16	2511144	2511144	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggagcccgaacccccaggcCtggggcgggcctcagggacc	17	16	1	0	rs34653281		TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr16:2511144C>G	uc002cqh.2	+	4	555	c.524C>G	c.(523-525)CCT>CGT	p.P175R	C16orf59_uc002cqf.1_Missense_Mutation_p.P175R|C16orf59_uc002cqg.1_Missense_Mutation_p.P8R|C16orf59_uc002cqi.2_Missense_Mutation_p.P8R|C16orf59_uc010uwb.1_Missense_Mutation_p.P8R	NM_025108	NP_079384	Q7L2K0	CP059_HUMAN	hypothetical protein LOC80178	175											0		Ovarian(90;0.17)				ACCCCCAGGCCTGGGGCGGGC	0.687													G	2511144	G	G	2511144	3	3	266	1	0	0	0	0	1	0	0	0	1823	681	24	5	538	5	C16orf59	16	2511144	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08		2511144	87843609	54	19112											
GRIN2A	2903	broad.mit.edu	37	chr16	9858638	9858638	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctctttggatgaagtcagcAgctcttttgggtgagtccat	11	9	3	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr16:9858638A>T	uc002czo.3	-	13	3311	c.2763T>A	c.(2761-2763)GCT>GCA	p.A921A	GRIN2A_uc010uym.1_Silent_p.A921A|GRIN2A_uc010uyn.1_Silent_p.A764A|GRIN2A_uc002czr.3_Silent_p.A921A	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	921	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGAAGTCAGCAGCTCTTTTGG	0.468													T	9858638	T	T	9858638	2	4	266	1	0	0	0	0	0	0	0	1	6779	175	7	5		5	GRIN2A	16	9858638	Silent	SNP	A	TCGA-76-6191-01A-12D-1696-08	7347494	9858638	80496115	55	19113											
LRRC48	83450	broad.mit.edu	37	chr17	17910458	17910458	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacctgcctaacgacctgcgCgcggtaggcggggcgggctg	18	13	0	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr17:17910458C>T	uc010vxd.1	+	13	1702	c.1323C>T	c.(1321-1323)CGC>CGT	p.R441R	LRRC48_uc002gsa.2_Silent_p.R441R|LRRC48_uc010vxc.1_Silent_p.R441R|LRRC48_uc002gsb.2_Silent_p.R441R	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	441						cytoplasm				pancreas(1)	1	all_neural(463;0.228)					ACGACCTGCGCGCGGTAGGCG	0.348													T	17910458	T	T	17910458	2	4	266	1	0	0	0	0	0	0	0	1	9005	755	27	1		1	LRRC48	17	17910458	Silent	SNP	C	TCGA-76-6191-01A-12D-1696-08		17910458	63284752	56	19114											
CD79B	974	broad.mit.edu	37	chr17	62007651	62007651	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagagccagctcacattgccGgaggcgctgttcatgtagca	12	12	2	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr17:62007651G>A	uc002jdq.1	-	3	296	c.213C>T	c.(211-213)TCC>TCT	p.S71S	CD79B_uc002jdo.1_Silent_p.S45S|CD79B_uc002jdp.1_Silent_p.S72S|CD79B_uc002jdr.1_Intron	NM_000626	NP_000617	P40259	CD79B_HUMAN	CD79B antigen isoform 1 precursor	71	Extracellular (Potential).|Ig-like V-type.				cell surface receptor linked signaling pathway|immune response	Golgi apparatus|integral to plasma membrane|nucleus	transmembrane receptor activity				0						TCACATTGCCGGAGGCGCTGT	0.567			Mis|O		DLBCL								A	62007651	A	A	62007651	2	1	266	1	0	0	0	0	0	0	0	1	3037	1103	39	2		2	CD79B	17	62007651	Silent	SNP	G	TCGA-76-6191-01A-12D-1696-08	44097193	62007651	19187559	57	19115											
CDH19	28513	broad.mit.edu	37	chr18	64211976	64211978	+	In_Frame_Del	DEL	CTT	-	-													cttttttaatataactattcCttcttgagtttcatgattag							TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr18:64211976_64211978delCTT	uc002lkc.1	-	6	1076_1078	c.938_940delAAG	c.(937-942)GAAGGA>GGA	p.E313del	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_In_Frame_Del_p.E313del|CDH19_uc002lkd.2_In_Frame_Del_p.E313del	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	313	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ATAACTATTCCTTCTTGAGTTTC	0.3													-	64211978	-	-	64211976	7	5	266	1	0	1	0	1	0	0	0	0	3104	690	24	0	1406	0	CDH19	18	64211976	In_Frame_Del	DEL	CTT	TCGA-76-6191-01A-12D-1696-08		64211976	13865272	58	19116											
THEG	51298	broad.mit.edu	37	chr19	362356	362356	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	cgggggctggccaccaccttCttggtgacatccagcacctc	11	16	1	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr19:362356C>T	uc002lol.2	-	8	1023	c.984G>A	c.(982-984)AAG>AAA	p.K328K	THEG_uc002lom.2_Silent_p.K304K	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	328	THEG 6.				cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCACCTTCTTGGTGACAT	0.617													T	362356	T	T	362356	2	4	266	1	0	0	0	0	0	0	0	1	15854	912	32	3		3	THEG	19	362356	Silent	SNP	C	TCGA-76-6191-01A-12D-1696-08		362356	58766627	59	19117											
COL5A3	50509	broad.mit.edu	37	chr19	10104318	10104318	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ttggcccttctcaccaggcaGcccagggaggccatcgaagc	12	15	1	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr19:10104318G>T	uc002mmq.1	-	18	1758	c.1672C>A	c.(1672-1674)CTG>ATG	p.L558M		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	558	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TCACCAGGCAGCCCAGGGAGG	0.587													T	10104318	T	T	10104318	3	4	266	1	0	0	0	0	1	0	0	0	3698	962	34	5	3765	5	COL5A3	19	10104318	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	9741962	10104318	49024665	60	19118											
RYR1	6261	broad.mit.edu	37	chr19	39001381	39001381	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggctaaagtgctgggcagcGgtggccacgcctctaacaag	14	12	1	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr19:39001381G>A	uc002oit.2	+	60	9212	c.9082G>A	c.(9082-9084)GGT>AGT	p.G3028S	RYR1_uc002oiu.2_Missense_Mutation_p.G3028S|RYR1_uc002oiv.1_5'UTR|RYR1_uc010xuf.1_5'Flank	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3028	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCTGGGCAGCGGTGGCCACGC	0.572													A	39001381	A	A	39001381	3	1	266	1	0	0	0	0	1	0	0	0	13768	1116	39	2	9320	2	RYR1	19	39001381	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08	28897063	39001381	20127602	61	19119											
PRX	57716	broad.mit.edu	37	chr19	40902416	40902416	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacttctgggaggtgcacatCgggcacggccatctcgggca	14	13	2	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr19:40902416C>T	uc002onr.2	-	7	2112	c.1843G>A	c.(1843-1845)GAT>AAT	p.D615N	PRX_uc002onq.2_Missense_Mutation_p.D476N|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	615	29.|55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGTGCACATCGGGCACGGCC	0.552													T	40902416	T	T	40902416	3	4	266	1	0	0	0	0	1	0	0	0	12642	884	31	2	2546	2	PRX	19	40902416	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	1901035	40902416	18226567	62	19120											
MATN4	8785	broad.mit.edu	37	chr20	43926658	43926658	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggctccgaggcgatctcGcgcagctccgcctccaccgc	12	19	1	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr20:43926658G>A	uc002xnn.2	-	8	1666	c.1479C>T	c.(1477-1479)CGC>CGT	p.R493R	MATN4_uc002xno.2_Silent_p.R452R|MATN4_uc002xnp.2_Silent_p.R411R|MATN4_uc010zwr.1_Silent_p.R441R|MATN4_uc002xnr.1_Silent_p.R493R	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	534	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				AGGCGATCTCGCGCAGCTCCG	0.672													A	43926658	A	A	43926658	2	1	266	1	0	0	0	0	0	0	0	1	9336	1074	38	1		1	MATN4	20	43926658	Silent	SNP	G	TCGA-76-6191-01A-12D-1696-08		43926658	19098862	63	19121											
NCOA5	57727	broad.mit.edu	37	chr20	44693706	44693706	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatgttgactgtgcaggagCggtgaatctggtgttgctgg	17	5	1	3	rs150367556		TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr20:44693706C>T	uc002xrd.2	-	5	1319	c.791G>A	c.(790-792)CGC>CAC	p.R264H	NCOA5_uc002xrc.2_Missense_Mutation_p.R152H|NCOA5_uc002xre.2_Missense_Mutation_p.R264H	NM_020967	NP_066018	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				TGTGCAGGAGCGGTGAATCTG	0.473													T	44693706	T	T	44693706	3	4	266	1	0	0	0	0	1	0	0	0	10232	768	27	1	960	1	NCOA5	20	44693706	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08	767048	44693706	18331814	64	19122											
COL6A1	1291	broad.mit.edu	37	chr21	47410308	47410308	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagggagagaagggcaagcGtggcatcgacggggtggacg	20	7	0	1			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr21:47410308G>A	uc002zhu.1	+	13	1076	c.974G>A	c.(973-975)CGT>CAT	p.R325H		NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	325	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	AAGGGCAAGCGTGGCATCGAC	0.478													A	47410308	A	A	47410308	3	1	266	1	0	0	0	0	1	0	0	0	3699	1145	40	1	1024	1	COL6A1	21	47410308	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08		47410308	719587	65	19123											
TCF20	6942	broad.mit.edu	37	chr22	42609517	42609517	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cccaacagtcttctcattaaCctttgggttcccgtcggatg	8	13	2	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chr22:42609517C>A	uc003bcj.1	-	1	1929	c.1795G>T	c.(1795-1797)GTT>TTT	p.V599F	TCF20_uc003bck.1_Missense_Mutation_p.V599F|TCF20_uc003bnt.2_Missense_Mutation_p.V599F	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	599					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						TTCTCATTAACCTTTGGGTTC	0.542													A	42609517	A	A	42609517	3	1	266	1	0	0	0	0	1	0	0	0	15687	507	18	5	4125	5	TCF20	22	42609517	Missense_Mutation	SNP	C	TCGA-76-6191-01A-12D-1696-08		42609517	8695049	66	19124											
OCRL	4952	broad.mit.edu	37	chrX	128696660	128696660	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cccatctggctgcacacgtgGaggactttgagagaaggaat	13	9	1	2			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chrX:128696660G>A	uc004euq.2	+	12	1306	c.1141G>A	c.(1141-1143)GAG>AAG	p.E381K	OCRL_uc004eur.2_Missense_Mutation_p.E381K	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	381					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						TGCACACGTGGAGGACTTTGA	0.438													A	128696660	A	A	128696660	3	1	266	1	0	0	0	0	1	0	0	0	10823	1175	41	3	1187	3	OCRL	23	128696660	Missense_Mutation	SNP	G	TCGA-76-6191-01A-12D-1696-08		128696660	26573900	67	19125											
MAMLD1	10046	broad.mit.edu	37	chrX	149639327	149639327	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatcttctaagccagcaacaGcagcagcagcagcagcagca	9	13	2	0			TCGA-76-6191-01A-12D-1696-08	TCGA-76-6191-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	4dbf66ef-4108-4a86-a8eb-6ba8cdefb4a2	29d36bce-4d93-4eca-9aef-1bbf21d82494	g.chrX:149639327G>A	uc004fee.1	+	3	1558	c.1482G>A	c.(1480-1482)CAG>CAA	p.Q494Q	MAMLD1_uc011mxt.1_Silent_p.Q456Q|MAMLD1_uc011mxu.1_Silent_p.Q469Q|MAMLD1_uc011mxv.1_Silent_p.Q469Q|MAMLD1_uc011mxw.1_Silent_p.Q421Q	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	494	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					GCcagcaacagcagcagcagc	0.433													A	149639327	A	A	149639327	2	1	266	1	0	0	0	0	0	0	0	1	9208	962	34	3		3	MAMLD1	23	149639327	Silent	SNP	G	TCGA-76-6191-01A-12D-1696-08	20942667	149639327	5631233	68	19126											
KLF17	128209	broad.mit.edu	37	chr1	44584644	44584644	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgagccggtggcaggcggCgcaccaggctgcccaggtga	18	13	0	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr1:44584644C>T	uc001clp.2	+	1	123	c.65C>T	c.(64-66)GCG>GTG	p.A22V	KLF17_uc009vxf.1_Intron	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	22					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TGGCAGGCGGCGCACCAGGCT	0.577													T	44584644	T	T	44584644	3	4	267	1	0	0	0	0	1	0	0	0	8345	768	27	1	67	1	KLF17	1	44584644	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08		44584644	204665977	1	19127											
CYP4A11	1579	broad.mit.edu	37	chr1	47395834	47395834	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttagggagcctcctgagacGcaggtggattccatttttgg	14	8	0	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr1:47395834G>A	uc001cqp.3	-	12	1564	c.1513C>T	c.(1513-1515)CGT>TGT	p.R505C		NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	505			NGIHLRLRRLPNPCEDKDQL -> MESTCVSGGSLTLVKTR TSFEGLHLPSCLPDPRFCPLPVCPYPVFCLPTFPSSHLPAV PQSACPSLSHLSPGLPTCLSTCLLPTCISCWEKS (in CYP4A11V).		long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	CTCCTGAGACGCAGGTGGATT	0.443													A	47395834	A	A	47395834	3	1	267	1	0	0	0	0	1	0	0	0	4183	1087	38	1	50	1	CYP4A11	1	47395834	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	2811190	47395834	201854787	2	19128											
ELTD1	64123	broad.mit.edu	37	chr1	79404873	79404873	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttgttaactgttctacttacTtttgttaaagttttattaat	4	4	1	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr1:79404873T>A	uc001diq.3	-	4	552	c.396A>T	c.(394-396)AAA>AAT	p.K132N		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	132	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTCTACTTACTTTTGTTAAAG	0.254													A	79404873	A	A	79404873	3	1	267	1	0	0	0	0	1	0	0	0	5084	1623	56	5	1724	5	ELTD1	1	79404873	Missense_Mutation	SNP	T	TCGA-76-6192-01A-11D-1696-08	32009039	79404873	169845748	3	19129											
BRDT	676	broad.mit.edu	37	chr1	92442915	92442915	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gactccataactactatgacGttgtcaaaaatccgatggat	7	9	1	1	rs142308966		TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr1:92442915G>A	uc001dok.3	+	6	1283	c.934G>A	c.(934-936)GTT>ATT	p.V312I	BRDT_uc001dol.3_Missense_Mutation_p.V312I|BRDT_uc010osz.1_Missense_Mutation_p.V316I|BRDT_uc009wdf.2_Missense_Mutation_p.V239I|BRDT_uc010ota.1_Missense_Mutation_p.V266I|BRDT_uc010otb.1_Missense_Mutation_p.V266I|BRDT_uc001dom.3_Missense_Mutation_p.V312I	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	312	Bromo 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		CTACTATGACGTTGTCAAAAA	0.284													A	92442915	A	A	92442915	3	1	267	1	0	0	0	0	1	0	0	0	1508	1145	40	1	952	1	BRDT	1	92442915	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	13038042	92442915	156807706	4	19130											
MNDA	4332	broad.mit.edu	37	chr1	158815528	158815528	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aatgtttcatgctacagtggCcagtaagactcaatatttcc	7	9	2	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr1:158815528C>A	uc001fsz.1	+	5	922	c.722C>A	c.(721-723)GCC>GAC	p.A241D		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	241	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					GCTACAGTGGCCAGTAAGACT	0.403													A	158815528	A	A	158815528	3	1	267	1	0	0	0	0	1	0	0	0	9676	739	26	5	736	5	MNDA	1	158815528	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	66372613	158815528	90435093	5	19131											
TOMM40L	84134	broad.mit.edu	37	chr1	161197734	161197734	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtatcggggagatgactacAcagccactctgaccctagga	11	11	1	3	rs146096318	by1000genomes	TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr1:161197734A>C	uc001fzd.2	+	6	668	c.439A>C	c.(439-441)ACA>CCA	p.T147P	TOMM40L_uc010pkk.1_RNA|TOMM40L_uc010pkl.1_Missense_Mutation_p.T113P|TOMM40L_uc009wue.2_Missense_Mutation_p.T29P|TOMM40L_uc009wuf.1_RNA|TOMM40L_uc001fze.2_Missense_Mutation_p.T147P	NM_032174	NP_115550	Q969M1	TM40L_HUMAN	translocase of outer mitochondrial membrane 40	147					protein transport	mitochondrial outer membrane|pore complex	porin activity|voltage-gated anion channel activity			large_intestine(1)	1	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGATGACTACACAGCCACTCT	0.522											OREG0013943	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	161197734	C	C	161197734	3	2	267	1	0	0	0	0	1	0	0	0	16356	159	6	5	457	5	TOMM40L	1	161197734	Missense_Mutation	SNP	A	TCGA-76-6192-01A-11D-1696-08	2382206	161197734	88052887	6	19132											
ASPM	259266	broad.mit.edu	37	chr1	197060162	197060162	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cttttcttgtaatcttgctcGaaaccatctctgtttaaaac	4	10	3	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr1:197060162G>A	uc001gtu.2	-	23	9711	c.9454C>T	c.(9454-9456)CGA>TGA	p.R3152*	ASPM_uc001gtv.2_Nonsense_Mutation_p.R1567*|ASPM_uc001gtw.3_Nonsense_Mutation_p.R1000*	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	3152					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AATCTTGCTCGAAACCATCTC	0.289													A	197060162	A	A	197060162	4	1	267	1	0	0	0	0	0	1	0	0	1056	1066	37	2	1003	2	ASPM	1	197060162	Nonsense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	35862428	197060162	52190459	7	19133											
LHX9	56956	broad.mit.edu	37	chr1	197890610	197890610	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcctggtgtactgccgcgCccacttcgagaccctcttgc	10	17	1	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr1:197890610C>T	uc001guk.1	+	3	991	c.554C>T	c.(553-555)GCC>GTC	p.A185V	LHX9_uc001gui.1_Missense_Mutation_p.A176V|LHX9_uc001guj.1_Missense_Mutation_p.A191V	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	185	LIM zinc-binding 2.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						TACTGCCGCGCCCACTTCGAG	0.607													T	197890610	T	T	197890610	3	4	267	1	0	0	0	0	1	0	0	0	8777	739	26	3	596	3	LHX9	1	197890610	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	830448	197890610	51360011	8	19134											
PQLC3	130814	broad.mit.edu	37	chr2	11300636	11300636	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgttactatgggtatccgcCgctgacctacctggagtacc	11	12	0	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr2:11300636C>T	uc002rbc.2	+	2	321	c.188C>T	c.(187-189)CCG>CTG	p.P63L	PQLC3_uc010yjk.1_Missense_Mutation_p.P63L	NM_152391	NP_689604	Q8N755	PQLC3_HUMAN	PQ loop repeat containing 3 precursor	63						integral to membrane					0	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0978)|OV - Ovarian serous cystadenocarcinoma(76;0.132)		GGGTATCCGCCGCTGACCTAC	0.617													T	11300636	T	T	11300636	3	4	267	1	0	0	0	0	1	0	0	0	12420	652	23	2	194	2	PQLC3	2	11300636	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08		11300636	231898737	9	19135											
THSD7B	80731	broad.mit.edu	37	chr2	137814211	137814211	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtgtgcttgttccttacgctCgcggtgaagtcaagcctcgg	13	11	1	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr2:137814211C>T	uc002tva.1	+	2	268	c.268C>T	c.(268-270)CGC>TGC	p.R90C	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TCCTTACGCTCGCGGTGAAGT	0.542													T	137814211	T	T	137814211	3	4	267	1	0	0	0	0	1	0	0	0	15877	884	31	2	274	2	THSD7B	2	137814211	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	126513575	137814211	105385162	10	19136											
SCN7A	6332	broad.mit.edu	37	chr2	167262867	167262867	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gcaacttgaaaaagacagagCatactgttgccaaaggtttc	9	8	0	3			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr2:167262867C>A	uc002udu.1	-	25	4399	c.4272G>T	c.(4270-4272)ATG>ATT	p.M1424I		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1424					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AAAGACAGAGCATACTGTTGC	0.348													A	167262867	A	A	167262867	3	1	267	1	0	0	0	0	1	0	0	0	13923	710	25	5	780	5	SCN7A	2	167262867	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	29448656	167262867	75936506	11	19137											
PLEKHA3	65977	broad.mit.edu	37	chr2	179365815	179365815	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cactctataaaagaaccagtAtctacacttcaccgactctc	3	14	4	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr2:179365815A>T	uc002umn.2	+	7	1085	c.687A>T	c.(685-687)GTA>GTT	p.V229V		NM_019091	NP_061964	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A	229						cytoplasm|membrane				ovary(1)|kidney(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			AAGAACCAGTATCTACACTTC	0.378													T	179365815	T	T	179365815	2	4	267	1	0	0	0	0	0	0	0	1	12057	436	16	5		5	PLEKHA3	2	179365815	Silent	SNP	A	TCGA-76-6192-01A-11D-1696-08	12102948	179365815	63833558	12	19138											
SPATS2L	26010	broad.mit.edu	37	chr2	201303921	201303921	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catggaacaacagagaggtcAgatggcctacagtggtcagc	13	9	2	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr2:201303921A>C	uc002uvn.3	+	7	874	c.522A>C	c.(520-522)TCA>TCC	p.S174S	SPATS2L_uc010fst.2_Silent_p.S174S|SPATS2L_uc002uvo.3_Silent_p.S114S|SPATS2L_uc002uvp.3_Silent_p.S174S|SPATS2L_uc002uvq.3_Intron|SPATS2L_uc002uvr.3_Silent_p.S174S|SPATS2L_uc010zhc.1_Silent_p.S204S	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	174						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						CAGAGAGGTCAGATGGCCTAC	0.448													C	201303921	C	C	201303921	2	2	267	1	0	0	0	0	0	0	0	1	15019	175	7	5		5	SPATS2L	2	201303921	Silent	SNP	A	TCGA-76-6192-01A-11D-1696-08	21938106	201303921	41895452	13	19139											
UGT1A6	54578	broad.mit.edu	37	chr2	234602327	234602327	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctatctattttattgtctgtTttcaaagtatgaagaactcg	6	6	3	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr2:234602327T>G	uc002vuv.3	+	1	816	c.677T>G	c.(676-678)TTT>TGT	p.F226C	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Missense_Mutation_p.F226C	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	226					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		TATTGTCTGTTTTCAAAGTAT	0.398													G	234602327	G	G	234602327	3	3	267	1	0	0	0	0	1	0	0	0	16946	1841	64	5	679	5	UGT1A6	2	234602327	Missense_Mutation	SNP	T	TCGA-76-6192-01A-11D-1696-08	33298406	234602327	8597046	14	19140											
PER2	8864	broad.mit.edu	37	chr2	239157720	239157720	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tactgccacgtcgatggctgCgggcaggccgcccgtctgca	14	15	1	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr2:239157720C>T	uc002vyc.2	-	22	3838	c.3601G>A	c.(3601-3603)GCA>ACA	p.A1201T	PER2_uc010znv.1_Missense_Mutation_p.A1201T	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	1201	CRY binding domain (By similarity).				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TCGATGGCTGCGGGCAGGCCG	0.493													T	239157720	T	T	239157720	3	4	267	1	0	0	0	0	1	0	0	0	11730	768	27	1	174	1	PER2	2	239157720	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	4555393	239157720	4041653	15	19141											
CLSTN2	64084	broad.mit.edu	37	chr3	140275468	140275468	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccaggcagttcccaacggcGggtgtgcggcgcctcaaagt	14	13	1	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr3:140275468G>A	uc003etn.2	+	11	1978	c.1788G>A	c.(1786-1788)GCG>GCA	p.A596A	CLSTN2_uc003etm.2_Silent_p.A596A	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	596	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TCCCAACGGCGGGTGTGCGGC	0.577										HNSCC(16;0.037)			A	140275468	A	A	140275468	2	1	267	1	0	0	0	0	0	0	0	1	3562	1103	39	2		2	CLSTN2	3	140275468	Silent	SNP	G	TCGA-76-6192-01A-11D-1696-08		140275468	57746962	16	19142											
ZBTB38	253461	broad.mit.edu	37	chr3	141163945	141163945	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgagtgaagtgttcgatgaCgcaagtgaccaggattccac	12	8	0	4			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr3:141163945C>T	uc003etw.2	+	8	3697	c.2715C>T	c.(2713-2715)GAC>GAT	p.D905D	ZBTB38_uc010hun.2_Silent_p.D902D|ZBTB38_uc010huo.2_Silent_p.D905D|ZBTB38_uc003ety.2_Silent_p.D905D|ZBTB38_uc010hup.2_Silent_p.D906D	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	905					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TGTTCGATGACGCAAGTGACC	0.498													T	141163945	T	T	141163945	2	4	267	1	0	0	0	0	0	0	0	1	17536	535	19	1		1	ZBTB38	3	141163945	Silent	SNP	C	TCGA-76-6192-01A-11D-1696-08	888477	141163945	56858485	17	19143											
GRK7	131890	broad.mit.edu	37	chr3	141499458	141499458	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacatctacaacgtgggcacGcgtggcctggacatgagccg	13	13	1	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr3:141499458G>A	uc011bnd.1	+	2	939	c.855G>A	c.(853-855)ACG>ACA	p.T285T		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	285	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						ACGTGGGCACGCGTGGCCTGG	0.557													A	141499458	A	A	141499458	2	1	267	1	0	0	0	0	0	0	0	1	6794	1074	38	1		1	GRK7	3	141499458	Silent	SNP	G	TCGA-76-6192-01A-11D-1696-08	335513	141499458	56522972	18	19144											
TPRG1	285386	broad.mit.edu	37	chr3	189038544	189038544	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttgagacctacacagggctgAtgtcattcattggaaaccgc	10	10	2	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr3:189038544A>T	uc003frv.1	+	11	1990	c.763A>T	c.(763-765)ATG>TTG	p.M255L	TPRG1_uc003frw.1_Missense_Mutation_p.M255L	NM_198485	NP_940887	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	255											0	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		CACAGGGCTGATGTCATTCAT	0.433													T	189038544	T	T	189038544	3	4	267	1	0	0	0	0	1	0	0	0	16415	333	12	5	781	5	TPRG1	3	189038544	Missense_Mutation	SNP	A	TCGA-76-6192-01A-11D-1696-08	47539086	189038544	8983886	19	19145											
GAK	2580	broad.mit.edu	37	chr4	860238	860238	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggacggtcacagagtccgaaTtgagaaattcgccgaagaga	13	8	1	3			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr4:860238T>C	uc003gbm.3	-	22	3156	c.2957A>G	c.(2956-2958)AAT>AGT	p.N986S	GAK_uc003gbn.3_Missense_Mutation_p.N907S|GAK_uc010ibi.2_Missense_Mutation_p.N167S|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.N839S	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	986					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		AGAGTCCGAATTGAGAAATTC	0.622													C	860238	C	C	860238	3	2	267	1	0	0	0	0	1	0	0	0	6195	1493	52	4	1006	4	GAK	4	860238	Missense_Mutation	SNP	T	TCGA-76-6192-01A-11D-1696-08		860238	190294038	20	19146											
RASSF6	166824	broad.mit.edu	37	chr4	74477540	74477540	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tcctttttgagatggtctgaGgatatcctaaacatgagaat	9	6	1	3			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr4:74477540G>T	uc003hhd.1	-	2	192	c.69C>A	c.(67-69)TCC>TCA	p.S23S	RASSF6_uc003hhc.1_5'UTR|RASSF6_uc010iik.1_5'UTR|RASSF6_uc010iil.1_Intron	NM_201431	NP_958834	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family 6	23					apoptosis|signal transduction		protein binding			pancreas(2)	2	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GATGGTCTGAGGATATCCTAA	0.343													T	74477540	T	T	74477540	2	4	267	1	0	0	0	0	0	0	0	1	13090	987	35	5		5	RASSF6	4	74477540	Silent	SNP	G	TCGA-76-6192-01A-11D-1696-08	73617302	74477540	116676736	21	19147											
FRAS1	80144	broad.mit.edu	37	chr4	79343100	79343100	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accagggcaaagtcatgtacCgccctcccccggcagcaccc	9	19	1	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr4:79343100C>T	uc003hlb.2	+	34	5064	c.4624C>T	c.(4624-4626)CGC>TGC	p.R1542C	FRAS1_uc003hkw.2_Missense_Mutation_p.R1542C|FRAS1_uc010ijj.1_Intron	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1541	CSPG 4.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						AGTCATGTACCGCCCTCCCCC	0.567													T	79343100	T	T	79343100	3	4	267	1	0	0	0	0	1	0	0	0	6042	652	23	2	4758	2	FRAS1	4	79343100	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	4865560	79343100	111811176	22	19148											
AGXT2L1	64850	broad.mit.edu	37	chr4	109667592	109667592	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agttggtccaccatgaacttTgcatcttcttcagtgaagca	8	10	3	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr4:109667592T>C	uc003hzc.2	-	11	1447	c.1266A>G	c.(1264-1266)GCA>GCG	p.A422A	AGXT2L1_uc010imc.2_Silent_p.A416A|AGXT2L1_uc011cfm.1_Silent_p.A382A|AGXT2L1_uc011cfn.1_Silent_p.A349A|AGXT2L1_uc011cfo.1_Silent_p.A364A	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	422					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		CCATGAACTTTGCATCTTCTT	0.423													C	109667592	C	C	109667592	2	2	267	1	0	0	0	0	0	0	0	1	406	1799	63	4		4	AGXT2L1	4	109667592	Silent	SNP	T	TCGA-76-6192-01A-11D-1696-08	30324492	109667592	81486684	23	19149											
TRIO	7204	broad.mit.edu	37	chr5	14389446	14389446	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tggaagagattccacctggcAttgtaaacaaagaactcatc	8	9	1	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr5:14389446A>G	uc003jff.2	+	25	4003	c.3997A>G	c.(3997-3999)ATT>GTT	p.I1333V	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.I1284V|TRIO_uc003jfh.1_Missense_Mutation_p.I982V	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1333	DH 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCCACCTGGCATTGTAAACAA	0.408													G	14389446	G	G	14389446	3	3	267	1	0	0	0	0	1	0	0	0	16549	217	8	4	4095	4	TRIO	5	14389446	Missense_Mutation	SNP	A	TCGA-76-6192-01A-11D-1696-08		14389446	166525814	24	19150											
AP3B1	8546	broad.mit.edu	37	chr5	77477403	77477403	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgatctggatccatagtataCggcttcttctttttgtcagt	8	8	4	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr5:77477403C>T	uc003kfj.2	-	8	995	c.870G>A	c.(868-870)CCG>CCA	p.P290P		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	290					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		CCATAGTATACGGCTTCTTCT	0.343									Hermansky-Pudlak_syndrome				T	77477403	T	T	77477403	2	4	267	1	0	0	0	0	0	0	0	1	744	523	19	1		1	AP3B1	5	77477403	Silent	SNP	C	TCGA-76-6192-01A-11D-1696-08	63087957	77477403	103437857	25	19151											
RGMB	285704	broad.mit.edu	37	chr5	98128833	98128833	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	catgagtgtacagatcagaaAgtctaccaagctgtgacaga	10	8	2	5			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr5:98128833A>G	uc003knc.2	+	5	1215	c.813A>G	c.(811-813)AAA>AAG	p.K271K		NM_001012761	NP_001012779	Q6NW40	RGMB_HUMAN	RGM domain family, member B	230					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding				0		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		CAGATCAGAAAGTCTACCAAG	0.527													G	98128833	G	G	98128833	2	3	267	1	0	0	0	0	0	0	0	1	13281	69	3	4		4	RGMB	5	98128833	Silent	SNP	A	TCGA-76-6192-01A-11D-1696-08	20651430	98128833	82786427	26	19152											
PCDHA13	56136	broad.mit.edu	37	chr5	140263481	140263481	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcgcgcgactctggcgtgcCgcctctgggcagcaacgtga	15	15	2	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr5:140263481C>T	uc003lif.2	+	1	1628	c.1628C>T	c.(1627-1629)CCG>CTG	p.P543L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.P543L|PCDHA13_uc003lid.2_Missense_Mutation_p.P543L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	543	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGGCGTGCCGCCTCTGGGC	0.692													T	140263481	T	T	140263481	3	4	267	1	0	0	0	0	1	0	0	0	11523	652	23	2	1630	2	PCDHA13	5	140263481	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	42134648	140263481	40651779	27	19153											
PCDHGA3	56112	broad.mit.edu	37	chr5	140725753	140725753	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggcgctcaggctgcggcGctggcacaagtcacgcctgc	15	15	2	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr5:140725753G>A	uc003ljm.1	+	1	2153	c.2153G>A	c.(2152-2154)CGC>CAC	p.R718H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.R478H|PCDHGA3_uc011dap.1_Missense_Mutation_p.R718H	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	718	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCTGCGGCGCTGGCACAAG	0.677													A	140725753	A	A	140725753	3	1	267	1	0	0	0	0	1	0	0	0	11555	1087	38	1	2155	1	PCDHGA3	5	140725753	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	462272	140725753	40189507	28	19154											
CCDC99	54908	broad.mit.edu	37	chr5	169028402	169028402	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagaagtttatcgattaccGcctcagaaagaggagacaca	11	8	1	4			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr5:169028402G>A	uc003mae.3	+	11	1722	c.1443G>A	c.(1441-1443)CCG>CCA	p.P481P	CCDC99_uc010jjj.2_Silent_p.P410P|CCDC99_uc011deq.1_Silent_p.P298P|CCDC99_uc010jjk.2_Silent_p.P207P	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	coiled-coil domain containing 99	481					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCGATTACCGCCTCAGAAAG	0.438													A	169028402	A	A	169028402	2	1	267	1	0	0	0	0	0	0	0	1	2876	1074	38	1		1	CCDC99	5	169028402	Silent	SNP	G	TCGA-76-6192-01A-11D-1696-08	28302649	169028402	11886858	29	19155											
ZNF323	64288	broad.mit.edu	37	chr6	28297413	28297413	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtcccagatagggtcttcCtccactttcacaatcttaag	7	12	3	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr6:28297413C>T	uc003nla.2	-	2	448	c.48G>A	c.(46-48)GAG>GAA	p.E16E	ZNF323_uc003nld.2_Silent_p.E16E|ZNF323_uc010jra.2_Silent_p.E16E|ZNF323_uc003nlb.2_Intron|ZNF323_uc010jrb.2_Intron|ZNF323_uc003nlc.2_Silent_p.E16E	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	16					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TAGGGTCTTCCTCCACTTTCA	0.448													T	28297413	T	T	28297413	2	4	267	1	0	0	0	0	0	0	0	1	17840	680	24	3		3	ZNF323	6	28297413	Silent	SNP	C	TCGA-76-6192-01A-11D-1696-08		28297413	142817654	30	19156											
EHMT2	10919	broad.mit.edu	37	chr6	31856011	31856011	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cacacaggccttgtggaagcGgtgggccacacggaagtcag	15	11	1	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr6:31856011G>A	uc003nxz.1	-	13	1562	c.1552C>T	c.(1552-1554)CGC>TGC	p.R518C	EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Missense_Mutation_p.R309C|EHMT2_uc011don.1_Missense_Mutation_p.R541C|EHMT2_uc003nya.1_Missense_Mutation_p.R484C	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	518					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						TTGTGGAAGCGGTGGGCCACA	0.622													A	31856011	A	A	31856011	3	1	267	1	0	0	0	0	1	0	0	0	4984	1116	39	2	2144	2	EHMT2	6	31856011	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	3558598	31856011	139259056	31	19157											
SLC26A8	116369	broad.mit.edu	37	chr6	35980127	35980127	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaagattgtaagcacgcatcGtaggaacctgtgccatgagc	11	9	0	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr6:35980127G>A	uc003olm.2	-	3	322	c.211C>T	c.(211-213)CGA>TGA	p.R71*	SLC26A8_uc003oln.2_Nonsense_Mutation_p.R71*|SLC26A8_uc003oll.2_Nonsense_Mutation_p.R71*	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	71	Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						AGCACGCATCGTAGGAACCTG	0.468													A	35980127	A	A	35980127	4	1	267	1	0	0	0	0	0	1	0	0	14523	1153	40	1	2773	1	SLC26A8	6	35980127	Nonsense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	4124116	35980127	135134940	32	19158											
RAPGEF5	9771	broad.mit.edu	37	chr7	22202112	22202112	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agactttacgtttcctacgcGgaacgtctgagttttcctct	8	11	2	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr7:22202112G>A	uc003svg.2	-	13	1185	c.872C>T	c.(871-873)CCG>CTG	p.P291L	RAPGEF5_uc011jyl.1_5'UTR	NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	141	N-terminal Ras-GEF.				nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						TTTCCTACGCGGAACGTCTGA	0.343													A	22202112	A	A	22202112	3	1	267	1	0	0	0	0	1	0	0	0	13047	1116	39	2	1376	2	RAPGEF5	7	22202112	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08		22202112	136936551	33	19159											
ANLN	54443	broad.mit.edu	37	chr7	36478889	36478889	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gaattccagtgttgaagaaaGaggttttctagtaagtaaca	10	4	1	3			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr7:36478889G>C	uc003tff.2	+	21	3164	c.2960G>C	c.(2959-2961)AGA>ACA	p.R987T	ANLN_uc011kaz.1_Missense_Mutation_p.R899T|ANLN_uc003tfg.2_Missense_Mutation_p.R950T|ANLN_uc010kxe.2_Missense_Mutation_p.R949T	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	987	PH.|Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						GTTGAAGAAAGAGGTTTTCTA	0.303													C	36478889	C	C	36478889	3	2	267	1	0	0	0	0	1	0	0	0	694	942	33	5	3042	5	ANLN	7	36478889	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	14276777	36478889	122659774	34	19160											
TNS3	64759	broad.mit.edu	37	chr7	47336762	47336762	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcccctcggaaggaatggctGtctcgaacaatgaatgagcc	12	11	1	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr7:47336762G>A	uc003tnv.2	-	24	3961	c.3594C>T	c.(3592-3594)GAC>GAT	p.D1198D	TNS3_uc003tnw.2_Silent_p.D1198D	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	1198	SH2.					focal adhesion	protein binding			ovary(4)	4						AGGAATGGCTGTCTCGAACAA	0.567													A	47336762	A	A	47336762	2	1	267	1	0	0	0	0	0	0	0	1	16341	1368	48	3		3	TNS3	7	47336762	Silent	SNP	G	TCGA-76-6192-01A-11D-1696-08	10857873	47336762	111801901	35	19161											
PCLO	27445	broad.mit.edu	37	chr7	82764222	82764222	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtttggccagcggtaggtcGtgggccagggggtgttggtg	21	6	0	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr7:82764222G>A	uc003uhx.2	-	3	2933	c.2644C>T	c.(2644-2646)CGA>TGA	p.R882*	PCLO_uc003uhv.2_Nonsense_Mutation_p.R882*	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	828	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCGGTAGGTCGTGGGCCAGGG	0.517													A	82764222	A	A	82764222	4	1	267	1	0	0	0	0	0	1	0	0	11583	1153	40	1	12893	1	PCLO	7	82764222	Nonsense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	35427460	82764222	76374441	36	19162											
MUC17	140453	broad.mit.edu	37	chr7	100674926	100674926	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtacaacatctacaaatgtcGtggagccaagaatgtatttg	9	7	1	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr7:100674926G>A	uc003uxp.1	+	3	282	c.229G>A	c.(229-231)GTG>ATG	p.V77M	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	77	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACAAATGTCGTGGAGCCAAG	0.448													A	100674926	A	A	100674926	3	1	267	1	0	0	0	0	1	0	0	0	9974	1145	40	1	239	1	MUC17	7	100674926	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	17910704	100674926	58463737	37	19163											
ASB10	136371	broad.mit.edu	37	chr7	150878052	150878052	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagggcccctggccagacacGgacggcgccatggttgagca	16	13	0	2	rs104886484		TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr7:150878052G>A	uc003wjm.1	-	3	1339	c.1213C>T	c.(1213-1215)CGT>TGT	p.R405C	ASB10_uc003wjl.1_Missense_Mutation_p.R405C|ASB10_uc003wjn.1_Missense_Mutation_p.R345C	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	360	ANK 7.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGCCAGACACGGACGGCGCCA	0.701													A	150878052	A	A	150878052	3	1	267	1	0	0	0	0	1	0	0	0	1014	1116	39	2	337	2	ASB10	7	150878052	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	50203126	150878052	8260611	38	19164											
MLL3	58508	broad.mit.edu	37	chr7	151921652	151921652	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccttcccacaggcctcacacAcagtgcactcaagacacctc	5	19	2	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr7:151921652A>C	uc003wla.2	-	19	3245	c.3026T>G	c.(3025-3027)GTG>GGG	p.V1009G	MLL3_uc003wkz.2_Missense_Mutation_p.V70G	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1009	PHD-type 5.|PHD-type 4.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGCCTCACACACAGTGCACTC	0.448			N		medulloblastoma								C	151921652	C	C	151921652	3	2	267	1	0	0	0	0	1	0	0	0	9622	159	6	5	11873	5	MLL3	7	151921652	Missense_Mutation	SNP	A	TCGA-76-6192-01A-11D-1696-08	1043600	151921652	7217011	39	19165											
NFIB	4781	broad.mit.edu	37	chr9	14307176	14307176	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatccagacgccagactttgTctgcctgtcgcaggcagtcg	12	13	1	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr9:14307176T>C	uc003zle.2	-	2	809	c.374A>G	c.(373-375)GAC>GGC	p.D125G	NFIB_uc003zlf.2_Missense_Mutation_p.D125G|NFIB_uc011lmo.1_Missense_Mutation_p.D125G	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	125	CTF/NF-I.				anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		CCAGACTTTGTCTGCCTGTCG	0.522			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								C	14307176	C	C	14307176	3	2	267	1	0	0	0	0	1	0	0	0	10371	1667	58	4	920	4	NFIB	9	14307176	Missense_Mutation	SNP	T	TCGA-76-6192-01A-11D-1696-08		14307176	126906255	40	19166											
FAM75A6	389730	broad.mit.edu	37	chr9	43627272	43627272	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaagggttggcggtgggacAggggctgggcctggaaaagc	20	6	0	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr9:43627272A>G	uc011lrb.1	-	4	1444	c.1415T>C	c.(1414-1416)CTG>CCG	p.L472P		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	472						integral to membrane					0						GCGGTGGGACAGGGGCTGGGC	0.522													G	43627272	G	G	43627272	3	3	267	1	0	0	0	0	1	0	0	0	5622	188	7	4	2620	4	FAM75A6	9	43627272	Missense_Mutation	SNP	A	TCGA-76-6192-01A-11D-1696-08	29320096	43627272	97586159	41	19167											
TMC1	117531	broad.mit.edu	37	chr9	75445373	75445373	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctttttaatttagtttggcCatctattatctcaatgctac	4	8	3	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr9:75445373C>T	uc004aiz.1	+	22	2676	c.2136C>T	c.(2134-2136)GCC>GCT	p.A712A	TMC1_uc010moz.1_Silent_p.A670A|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Silent_p.A566A|TMC1_uc010mpa.1_Silent_p.A566A	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	712	Helical; (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						TTAGTTTGGCCATCTATTATC	0.284													T	75445373	T	T	75445373	2	4	267	1	0	0	0	0	0	0	0	1	15981	581	21	3		3	TMC1	9	75445373	Silent	SNP	C	TCGA-76-6192-01A-11D-1696-08	31818101	75445373	65768058	42	19168											
PMPCA	23203	broad.mit.edu	37	chr9	139311437	139311437	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacacagttggcctccaccGtttctgccccacagaaaacg	8	15	1	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr9:139311437G>A	uc004chl.2	+	7	673	c.668G>A	c.(667-669)CGT>CAT	p.R223H	PMPCA_uc010nbl.2_Missense_Mutation_p.R123H|PMPCA_uc011mdz.1_Missense_Mutation_p.R92H|PMPCA_uc004chm.1_5'UTR|PMPCA_uc004chn.1_5'Flank	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	223					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		GGCCTCCACCGTTTCTGCCCC	0.562													A	139311437	A	A	139311437	3	1	267	1	0	0	0	0	1	0	0	0	12140	1145	40	1	694	1	PMPCA	9	139311437	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	63866064	139311437	1901994	43	19169											
ITGA8	8516	broad.mit.edu	37	chr10	15649777	15649777	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttatcaaggaagagcgtccGtttaatagctcctttctgtt	9	8	2	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr10:15649777G>A	uc001ioc.1	-	17	1663	c.1663C>T	c.(1663-1665)CGG>TGG	p.R555W	ITGA8_uc010qcb.1_Missense_Mutation_p.R540W	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	555	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						AAGAGCGTCCGTTTAATAGCT	0.433													A	15649777	A	A	15649777	3	1	267	1	0	0	0	0	1	0	0	0	7882	1144	40	1	1584	1	ITGA8	10	15649777	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08		15649777	119884970	44	19170											
PTEN	5728	broad.mit.edu	37	chr10	89720650	89720650	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttctttttttttttttttaGgacaaaatgtttcacttttg	4	4	2	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr10:89720650G>A	uc001kfb.2	+	9	1833	c.802_splice	c.e9-1	p.D268_splice		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(3)|p.N212fs*1(2)|p.Y27fs*1(2)|p.M264fs*8(2)|p.G165_*404del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		tttttttttAGGACAAAATGT	0.239		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89720650	A	A	89720650	5	1	267	1	0	0	0	0	0	0	1	0	12738	1014	35	3	831	3	PTEN	10	89720650	Splice_Site	SNP	G	TCGA-76-6192-01A-11D-1696-08	74070873	89720650	45814097	45	19171											
TRIM21	6737	broad.mit.edu	37	chr11	4406616	4406616	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accaggactgaagaagggccGcagaggtcctgtaaaggcac	14	10	0	3			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr11:4406616G>A	uc001lyy.1	-	7	1440	c.1327C>T	c.(1327-1329)CGG>TGG	p.R443W		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	443	B30.2/SPRY.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		AAGAAGGGCCGCAGAGGTCCT	0.488													A	4406616	A	A	4406616	3	1	267	1	0	0	0	0	1	0	0	0	16492	1086	38	1	104	1	TRIM21	11	4406616	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08		4406616	130599900	46	19172											
OR52E4	390081	broad.mit.edu	37	chr11	5906308	5906308	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gcatttttttcttttatgacAcatcgttttggccaaaacat	5	8	1	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr11:5906308A>T	uc010qzs.1	+	1	786	c.786A>T	c.(784-786)ACA>ACT	p.T262T	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTTTATGACACATCGTTTTG	0.423													T	5906308	T	T	5906308	2	4	267	1	0	0	0	0	0	0	0	1	11116	146	6	5		5	OR52E4	11	5906308	Silent	SNP	A	TCGA-76-6192-01A-11D-1696-08	1499692	5906308	129100208	47	19173											
BTBD10	84280	broad.mit.edu	37	chr11	13441120	13441120	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttatattccgagctccttcTtttgcattttcatatacaaa	3	10	2	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr11:13441120T>C	uc001mkz.2	-	4	728	c.471A>G	c.(469-471)AAA>AAG	p.K157K	BTBD10_uc010rcl.1_Silent_p.K165K|BTBD10_uc001mla.2_Silent_p.K141K|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Silent_p.K109K|BTBD10_uc010rcn.1_Silent_p.K126K|BTBD10_uc009ygo.2_Silent_p.K109K	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	157						nucleus					0				Epithelial(150;0.0214)		GAGCTCCTTCTTTTGCATTTT	0.418													C	13441120	C	C	13441120	2	2	267	1	0	0	0	0	0	0	0	1	1538	1606	56	4		4	BTBD10	11	13441120	Silent	SNP	T	TCGA-76-6192-01A-11D-1696-08	7534812	13441120	121565396	48	19174											
MMP7	4316	broad.mit.edu	37	chr11	102398591	102398591	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctgcattatttctatgaCgcgggagtttaacattccag	8	9	2	1	rs145006821	by1000genomes	TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr11:102398591C>T	uc001phb.2	-	2	279	c.232G>A	c.(232-234)GTC>ATC	p.V78I	MMP7_uc009yxd.2_Missense_Mutation_p.V78I|MMP7_uc010rus.1_Missense_Mutation_p.V78I	NM_002423	NP_002414	P09237	MMP7_HUMAN	matrix metalloproteinase 7 preproprotein	78					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(1)	1	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		ATTTCTATGACGCGGGAGTTT	0.408													T	102398591	T	T	102398591	3	4	267	1	0	0	0	0	1	0	0	0	9667	536	19	1	591	1	MMP7	11	102398591	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	88957471	102398591	32607925	49	19175											
TEAD4	7004	broad.mit.edu	37	chr12	3121377	3121377	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggctcgtcgcaaagctcgCgagatccaggccaagctaaa	11	13	0	1	rs112112805		TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr12:3121377C>T	uc010sej.1	+	5	607	c.330C>T	c.(328-330)CGC>CGT	p.R110R	TEAD4_uc010sek.1_Silent_p.R110R|TEAD4_uc001qln.2_5'UTR	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	111					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			GCAAAGCTCGCGAGATCCAGG	0.597													T	3121377	T	T	3121377	2	4	267	1	0	0	0	0	0	0	0	1	15738	755	27	1		1	TEAD4	12	3121377	Silent	SNP	C	TCGA-76-6192-01A-11D-1696-08		3121377	130730518	50	19176											
PLEKHA5	54477	broad.mit.edu	37	chr12	19436297	19436297	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctaccctgaaggttatagaaCactcccaagaaacagcaaga	7	11	0	4			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr12:19436297C>G	uc001reb.2	+	11	1465	c.1379C>G	c.(1378-1380)ACA>AGA	p.T460R	PLEKHA5_uc010sie.1_Missense_Mutation_p.T466R|PLEKHA5_uc001rea.2_Missense_Mutation_p.T460R|PLEKHA5_uc009zin.2_Missense_Mutation_p.T218R|PLEKHA5_uc010sif.1_Missense_Mutation_p.T352R|PLEKHA5_uc010sig.1_Missense_Mutation_p.T352R|PLEKHA5_uc010sih.1_Missense_Mutation_p.T352R|PLEKHA5_uc001rec.1_Missense_Mutation_p.T148R	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	460							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GGTTATAGAACACTCCCAAGA	0.438													G	19436297	G	G	19436297	3	3	267	1	0	0	0	0	1	0	0	0	12059	478	17	5	1421	5	PLEKHA5	12	19436297	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	16314920	19436297	114415598	51	19177											
CYP27B1	1594	broad.mit.edu	37	chr12	58158677	58158677	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctccgttcctcatggctgCctctgcctctcgccgctcca	7	20	3	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr12:58158677C>T	uc001spz.1	-	5	975	c.823G>A	c.(823-825)GCA>ACA	p.A275T	CYP27B1_uc001sqa.1_Missense_Mutation_p.A40T|CYP27B1_uc001sqb.1_Missense_Mutation_p.G155D|CYP27B1_uc001sqc.1_Missense_Mutation_p.G155D	NM_000785	NP_000776	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B,	275					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)	3	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	CTCATGGCTGCCTCTGCCTCT	0.617													T	58158677	T	T	58158677	3	4	267	1	0	0	0	0	1	0	0	0	4159	739	26	3	723	3	CYP27B1	12	58158677	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	38722380	58158677	75693218	52	19178											
ATP8A2	51761	broad.mit.edu	37	chr13	26343355	26343355	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaccaacaactcggattaCgccatcgcacaggtcagcag	9	15	1	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr13:26343355C>T	uc001uqk.2	+	26	2698	c.2556C>T	c.(2554-2556)TAC>TAT	p.Y852Y	ATP8A2_uc010tdi.1_Silent_p.Y812Y|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Silent_p.Y402Y	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	812	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ACTCGGATTACGCCATCGCAC	0.582													T	26343355	T	T	26343355	2	4	267	1	0	0	0	0	0	0	0	1	1193	547	19	1		1	ATP8A2	13	26343355	Silent	SNP	C	TCGA-76-6192-01A-11D-1696-08		26343355	88826523	53	19179											
SFRS5	6430	broad.mit.edu	37	chr14	70234973	70234973	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	atggacggataagagatattGatctgaaaagaggctttggt	13	3	1	4			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr14:70234973G>T	uc001xll.2	+	3	1551	c.100G>T	c.(100-102)GAT>TAT	p.D34Y	SFRS5_uc001xlm.2_RNA|SFRS5_uc001xln.1_Missense_Mutation_p.D34Y|SFRS5_uc001xlo.2_Missense_Mutation_p.D34Y|SFRS5_uc001xlp.2_Missense_Mutation_p.D34Y|SFRS5_uc001xlq.2_Missense_Mutation_p.D34Y	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5	34	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)		AAGAGATATTGATCTGAAAAG	0.428													T	70234973	T	T	70234973	3	4	267	1	0	0	0	0	1	0	0	0	14180	1290	45	5	102	5	SFRS5	14	70234973	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08		70234973	37114567	54	19180											
SEMA6D	80031	broad.mit.edu	37	chr15	48053911	48053911	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtggcctggcaagatgcccAtttgatgccagacaaaccaa	10	11	0	3			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr15:48053911A>G	uc010bek.2	+	7	861	c.501A>G	c.(499-501)CCA>CCG	p.P167P	SEMA6D_uc001zvw.2_Silent_p.P167P|SEMA6D_uc001zvx.1_Silent_p.P167P|SEMA6D_uc001zvy.2_Silent_p.P167P|SEMA6D_uc001zvz.2_Silent_p.P167P|SEMA6D_uc001zwa.2_Silent_p.P167P|SEMA6D_uc001zwb.2_Silent_p.P167P|SEMA6D_uc001zwc.2_Silent_p.P167P	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	167	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CAAGATGCCCATTTGATGCCA	0.373													G	48053911	G	G	48053911	2	3	267	1	0	0	0	0	0	0	0	1	14042	204	8	4		4	SEMA6D	15	48053911	Silent	SNP	A	TCGA-76-6192-01A-11D-1696-08		48053911	54477481	55	19181											
CSNK1G1	53944	broad.mit.edu	37	chr15	64472574	64472574	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctccactacctccacctcgGcatgagctgtgattggtgca	9	15	0	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr15:64472574G>A	uc002anf.2	-	11	1667	c.1187C>T	c.(1186-1188)GCC>GTC	p.A396V	CSNK1G1_uc002ane.2_RNA|CSNK1G1_uc002ang.1_Missense_Mutation_p.A396V|CSNK1G1_uc002anh.1_Missense_Mutation_p.A433V	NM_022048	NP_071331	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	396					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0						CTCCACCTCGGCATGAGCTGT	0.483													A	64472574	A	A	64472574	3	1	267	1	0	0	0	0	1	0	0	0	3954	1203	42	3	89	3	CSNK1G1	15	64472574	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	16418663	64472574	38058818	56	19182											
ITGAX	3687	broad.mit.edu	37	chr16	31383748	31383748	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taccttgcgtctgaacttcaCgctggtgggcaagcccctcc	10	15	2	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr16:31383748C>T	uc002ebu.1	+	18	2277	c.2210C>T	c.(2209-2211)ACG>ATG	p.T737M	ITGAX_uc002ebt.2_Missense_Mutation_p.T737M	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	737	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTGAACTTCACGCTGGTGGGC	0.642													T	31383748	T	T	31383748	3	4	267	1	0	0	0	0	1	0	0	0	7889	536	19	1	2280	1	ITGAX	16	31383748	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08		31383748	58971005	57	19183											
SPAG5	10615	broad.mit.edu	37	chr17	26919636	26919636	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgtagttgttcagaacagGgatttggtggagactcctct	12	6	2	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr17:26919636G>A	uc002hbq.2	-	3	718	c.626C>T	c.(625-627)CCC>CTC	p.P209L	SGK494_uc010waq.1_Intron	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	209					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					TTCAGAACAGGGATTTGGTGG	0.483													A	26919636	A	A	26919636	3	1	267	1	0	0	0	0	1	0	0	0	14981	1232	43	3	3043	3	SPAG5	17	26919636	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08		26919636	54275574	58	19184											
ADAMTS10	81794	broad.mit.edu	37	chr19	8661947	8661947	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccatggccgctgtggttcaCgatggatttctgccacttac	11	12	2	0	rs141147742		TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr19:8661947C>T	uc002mkj.1	-	8	1238	c.964G>A	c.(964-966)GTG>ATG	p.V322M	ADAMTS10_uc002mkk.1_Translation_Start_Site	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	322	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						CTGTGGTTCACGATGGATTTC	0.572													T	8661947	T	T	8661947	3	4	267	1	0	0	0	0	1	0	0	0	256	536	19	1	2423	1	ADAMTS10	19	8661947	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08		8661947	50467036	59	19185											
SLC1A6	6511	broad.mit.edu	37	chr19	15073138	15073138	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtcctggttaccaccctcGtgctgtactgcgtcttgaac	10	13	1	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr19:15073138G>A	uc002naa.1	-	5	619	c.611C>T	c.(610-612)ACG>ATG	p.T204M	SLC1A6_uc010dzu.1_Missense_Mutation_p.T204M|SLC1A6_uc010xod.1_Missense_Mutation_p.T140M|SLC1A6_uc002nab.2_Missense_Mutation_p.T204M|SLC1A6_uc002nac.2_Missense_Mutation_p.T204M	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	204	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	TACCACCCTCGTGCTGTACTG	0.413													A	15073138	A	A	15073138	3	1	267	1	0	0	0	0	1	0	0	0	14436	1145	40	1	1103	1	SLC1A6	19	15073138	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	6411191	15073138	44055845	60	19186											
HIF3A	64344	broad.mit.edu	37	chr19	46807322	46807322	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcaccatcagctacctgcGcatgcaccgcctctgcgccg	8	20	3	0			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr19:46807322G>A	uc002peh.2	+	2	223	c.194G>A	c.(193-195)CGC>CAC	p.R65H	HIF3A_uc002pef.1_Missense_Mutation_p.R65H|HIF3A_uc002peg.3_Missense_Mutation_p.R65H|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Missense_Mutation_p.R9H|HIF3A_uc002pej.1_Missense_Mutation_p.A45T|HIF3A_uc002pek.2_Missense_Mutation_p.R9H|HIF3A_uc010xxy.1_Missense_Mutation_p.A45T|HIF3A_uc002pel.2_Missense_Mutation_p.R63H|HIF3A_uc010xxz.1_Missense_Mutation_p.A63T	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	65	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		AGCTACCTGCGCATGCACCGC	0.672													A	46807322	A	A	46807322	3	1	267	1	0	0	0	0	1	0	0	0	7105	1087	38	1	224	1	HIF3A	19	46807322	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	31734184	46807322	12321661	61	19187											
SIGLEC14	100049587	broad.mit.edu	37	chr19	52149086	52149086	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcacctgagctccttggcGtttcacctgacaggtgaggt	13	11	2	3			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr19:52149086G>A	uc002pxf.3	-	3	769	c.649C>T	c.(649-651)CGC>TGC	p.R217C		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	217	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		GCTCCTTGGCGTTTCACCTGA	0.642													A	52149086	A	A	52149086	3	1	267	1	0	0	0	0	1	0	0	0	14309	1145	40	1	561	1	SIGLEC14	19	52149086	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	5341764	52149086	6979897	62	19188											
NLRP5	126206	broad.mit.edu	37	chr19	56552352	56552352	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcagccctcgtcagcaacCggagcttgacacacctgtgc	9	17	2	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr19:56552352C>T	uc002qmj.2	+	11	2851	c.2851C>T	c.(2851-2853)CGG>TGG	p.R951W	NLRP5_uc002qmi.2_Missense_Mutation_p.R932W	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	951	LRR 8.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CGTCAGCAACCGGAGCTTGAC	0.562													T	56552352	T	T	56552352	3	4	267	1	0	0	0	0	1	0	0	0	10480	643	23	2	2893	2	NLRP5	19	56552352	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08	4403266	56552352	2576631	63	19189											
SEL1L2	80343	broad.mit.edu	37	chr20	13830889	13830889	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtttccagtttcatgacgGcaaagagcacaggtatgtgg	12	7	1	2			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr20:13830889G>A	uc010gcf.2	-	19	1977	c.1895C>T	c.(1894-1896)GCC>GTC	p.A632V	SEL1L2_uc002woq.3_Missense_Mutation_p.A493V|SEL1L2_uc010zrl.1_Missense_Mutation_p.A519V|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	632	Extracellular (Potential).					integral to membrane	binding			ovary(2)	2						TTTCATGACGGCAAAGAGCAC	0.458													A	13830889	A	A	13830889	3	1	267	1	0	0	0	0	1	0	0	0	14011	1203	42	3	179	3	SEL1L2	20	13830889	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08		13830889	49194631	64	19190											
TSHZ2	128553	broad.mit.edu	37	chr20	51870967	51870967	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaccccggctaagaaacgcGtttttgatgtcaatcggccg	10	12	2	2	rs138844500	byFrequency	TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr20:51870967G>A	uc002xwo.2	+	2	1926	c.970G>A	c.(970-972)GTT>ATT	p.V324I		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	324					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			TAAGAAACGCGTTTTTGATGT	0.458													A	51870967	A	A	51870967	3	1	267	1	0	0	0	0	1	0	0	0	16621	1145	40	1	976	1	TSHZ2	20	51870967	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08	38040078	51870967	11154553	65	19191											
SIM2	6493	broad.mit.edu	37	chr21	38092132	38092132	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccacggcaggtggagctcaCgggcaacagtatttatgaat	12	9	1	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr21:38092132C>T	uc002yvr.2	+	4	415	c.359C>T	c.(358-360)ACG>ATG	p.T120M	SIM2_uc002yvq.2_Missense_Mutation_p.T120M	NM_005069	NP_005060	Q14190	SIM2_HUMAN	single-minded homolog 2 long isoform	120	PAS 1.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1						GTGGAGCTCACGGGCAACAGT	0.602													T	38092132	T	T	38092132	3	4	267	1	0	0	0	0	1	0	0	0	14324	536	19	1	373	1	SIM2	21	38092132	Missense_Mutation	SNP	C	TCGA-76-6192-01A-11D-1696-08		38092132	10037763	66	19192											
GCAT	23464	broad.mit.edu	37	chr22	38211153	38211153	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcatcggctgcgcctggtGgccactgatggggccttttc	14	12	0	1			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chr22:38211153G>A	uc003atz.2	+	5	617	c.597G>A	c.(595-597)GTG>GTA	p.V199V	GCAT_uc003aua.1_Silent_p.V225V	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	199					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TGCGCCTGGTGGCCACTGATG	0.577													A	38211153	A	A	38211153	2	1	267	1	0	0	0	0	0	0	0	1	6284	1335	47	3		3	GCAT	22	38211153	Silent	SNP	G	TCGA-76-6192-01A-11D-1696-08		38211153	13093413	67	19193											
LUZP4	51213	broad.mit.edu	37	chrX	114541268	114541268	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagtcactcagagagatctcGtggccactgagagagatctc	11	10	4	4			TCGA-76-6192-01A-11D-1696-08	TCGA-76-6192-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	c29754bc-44e8-4980-98a1-b8d69700f4a3	cf01308d-b06f-488b-b5e8-a37d998eed16	g.chrX:114541268G>A	uc004eqa.2	+	4	875	c.841G>A	c.(841-843)GTG>ATG	p.V281M	LUZP4_uc004eqb.2_Missense_Mutation_p.V199M	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	281						nucleus				ovary(2)	2						GAGAGATCTCGTGGCCACTGA	0.428													A	114541268	A	A	114541268	3	1	267	1	0	0	0	0	1	0	0	0	9088	1145	40	1	855	1	LUZP4	23	114541268	Missense_Mutation	SNP	G	TCGA-76-6192-01A-11D-1696-08		114541268	40729292	68	19194											
SLC45A1	50651	broad.mit.edu	37	chr1	8395553	8395553	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcgagctgacgggctccagCgagcgcgcggagcagcctct	16	14	1	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr1:8395553C>T	uc001apb.2	+	5	1500	c.1500C>T	c.(1498-1500)AGC>AGT	p.S500S	SLC45A1_uc001apc.2_Silent_p.S198S	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	500					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CGGGCTCCAGCGAGCGCGCGG	0.647													T	8395553	T	T	8395553	2	4	268	1	0	0	0	0	0	0	0	1	14640	767	27	1		1	SLC45A1	1	8395553	Silent	SNP	C	TCGA-76-6193-01A-11D-1696-08		8395553	240855068	1	19195											
ST6GALNAC3	256435	broad.mit.edu	37	chr1	77094323	77094323	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggacagaagggtatagaaaAgtcccctaccattattatga	9	7	0	3			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr1:77094323A>T	uc001dhh.2	+	5	913	c.750A>T	c.(748-750)AAA>AAT	p.K250N	ST6GALNAC3_uc010orh.1_Missense_Mutation_p.K149N	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	250	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						GGTATAGAAAAGTCCCCTACC	0.328													T	77094323	T	T	77094323	3	4	268	1	0	0	0	0	1	0	0	0	15224	69	3	5	782	5	ST6GALNAC3	1	77094323	Missense_Mutation	SNP	A	TCGA-76-6193-01A-11D-1696-08	68698770	77094323	172156298	2	19196											
HCN3	57657	broad.mit.edu	37	chr1	155254428	155254428	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	caggcacctgtaggcatgccCgacgtctggctcaccatgct	11	15	2	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr1:155254428C>G	uc001fjz.1	+	4	977	c.969C>G	c.(967-969)CCC>CCG	p.P323P	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Intron	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	323	Extracellular (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TAGGCATGCCCGACGTCTGGC	0.597													G	155254428	G	G	155254428	2	3	268	1	0	0	0	0	0	0	0	1	6998	639	23	5		5	HCN3	1	155254428	Silent	SNP	C	TCGA-76-6193-01A-11D-1696-08	78160105	155254428	93996193	3	19197											
CD1B	910	broad.mit.edu	37	chr1	158300836	158300836	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtctggataacatgaaaggaGgtcggcccctggaaggctgt	15	8	1	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr1:158300836G>A	uc001frx.2	-	2	186	c.78C>T	c.(76-78)ACC>ACT	p.T26T	CD1B_uc001frw.2_5'UTR|CD1B_uc010pic.1_Silent_p.T26T	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	26	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					CATGAAAGGAGGTCGGCCCCT	0.458													A	158300836	A	A	158300836	2	1	268	1	0	0	0	0	0	0	0	1	2975	987	35	3		3	CD1B	1	158300836	Silent	SNP	G	TCGA-76-6193-01A-11D-1696-08	3046408	158300836	90949785	4	19198											
VSIG8	391123	broad.mit.edu	37	chr1	159827989	159827989	+	Nonsense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atgaggttgatggaggcatcGtactggcttgggtctgaggc	17	6	1	3	rs138280068		TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr1:159827989G>C	uc001fuh.2	-	3	457	c.321C>G	c.(319-321)TAC>TAG	p.Y107*	C1orf204_uc001fug.1_5'Flank	NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	107	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					TGGAGGCATCGTACTGGCTTG	0.542													C	159827989	C	C	159827989	4	2	268	1	0	0	0	0	0	1	0	0	17223	1140	40	5	943	5	VSIG8	1	159827989	Nonsense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	1527153	159827989	89422632	5	19199											
ITLN2	142683	broad.mit.edu	37	chr1	160920979	160920979	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttcccacgcatgtcattctCgtgcacgctggccaccaggg	10	16	2	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr1:160920979C>T	uc001fxd.2	-	4	353	c.295G>A	c.(295-297)GAG>AAG	p.E99K	ITLN2_uc009wts.2_Missense_Mutation_p.E98K|ITLN2_uc010pju.1_Missense_Mutation_p.E16K	NM_080878	NP_543154	Q8WWU7	ITLN2_HUMAN	intelectin 2 precursor	99	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			ovary(1)	1	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			ATGTCATTCTCGTGCACGCTG	0.582													T	160920979	T	T	160920979	3	4	268	1	0	0	0	0	1	0	0	0	7911	893	31	2	702	2	ITLN2	1	160920979	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08	1092990	160920979	88329642	6	19200											
LAMC2	3918	broad.mit.edu	37	chr1	183207550	183207550	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgagagcatccttaaaaacCtcagaggttagtacttcatg	8	8	2	2			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr1:183207550C>T	uc001gqa.2	+	19	3177	c.2863C>T	c.(2863-2865)CTC>TTC	p.L955F	LAMC2_uc001gpz.3_Missense_Mutation_p.L955F|LAMC2_uc010poa.1_Missense_Mutation_p.L655F	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	955	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						CCTTAAAAACCTCAGAGGTTA	0.413													T	183207550	T	T	183207550	3	4	268	1	0	0	0	0	1	0	0	0	8615	681	24	3	2937	3	LAMC2	1	183207550	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08	22286571	183207550	66043071	7	19201											
KLF11	8462	broad.mit.edu	37	chr2	10188462	10188462	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgtgttcgtgggacctgCtgtgcctcagggagctgtga	15	10	1	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr2:10188462C>T	uc002raf.1	+	3	1160	c.998C>T	c.(997-999)GCT>GTT	p.A333V	KLF11_uc010yjc.1_Missense_Mutation_p.A316V	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	333					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GTGGGACCTGCTGTGCCTCAG	0.622											OREG0014425	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	10188462	T	T	10188462	3	4	268	1	0	0	0	0	1	0	0	0	8339	797	28	3	1008	3	KLF11	2	10188462	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08		10188462	233010911	8	19202											
ACTG2	72	broad.mit.edu	37	chr2	74140711	74140711	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgcctggacttggctggccGtgacctcacggactacctca	12	15	2	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr2:74140711G>A	uc002sjw.2	+	6	673	c.551G>A	c.(550-552)CGT>CAT	p.R184H	ACTG2_uc010fey.2_Missense_Mutation_p.R184H|ACTG2_uc010yrn.1_Missense_Mutation_p.R141H	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	184					muscle contraction	cytoskeleton|cytosol	ATP binding				0						TTGGCTGGCCGTGACCTCACG	0.552													A	74140711	A	A	74140711	3	1	268	1	0	0	0	0	1	0	0	0	197	1145	40	1	569	1	ACTG2	2	74140711	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	63952249	74140711	169058662	9	19203											
VIL1	7429	broad.mit.edu	37	chr2	219301877	219301877	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ggattgggaaacatgccaacGaggaggagaagaaggccgca	16	7	0	2			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr2:219301877G>A	uc002via.2	+	17	2067	c.2002G>A	c.(2002-2004)GAG>AAG	p.E668K	VIL1_uc010zke.1_Missense_Mutation_p.E357K|VIL1_uc002vib.2_Missense_Mutation_p.E668K	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	668	Gelsolin-like 6.|Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACATGCCAACGAGGAGGAGAA	0.577													A	219301877	A	A	219301877	3	1	268	1	0	0	0	0	1	0	0	0	17161	1059	37	2	2064	2	VIL1	2	219301877	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	145161166	219301877	23897496	10	19204											
RPL14	9045	broad.mit.edu	37	chr3	40499407	40499407	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcgcttcgtggaggttggCcgggtggcctatgtctcctt	16	10	1	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr3:40499407C>T	uc003ckg.2	+	2	81	c.30C>T	c.(28-30)GGC>GGT	p.G10G	RPL14_uc003ckh.2_Silent_p.G10G|RPL14_uc003cki.2_5'UTR	NM_003973	NP_003964	P50914	RL14_HUMAN	ribosomal protein L14	10					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGGAGGTTGGCCGGGTGGCCT	0.443													T	40499407	T	T	40499407	2	4	268	1	0	0	0	0	0	0	0	1	13561	726	26	3		3	RPL14	3	40499407	Silent	SNP	C	TCGA-76-6193-01A-11D-1696-08		40499407	157523023	11	19205											
CDCP1	64866	broad.mit.edu	37	chr3	45127459	45127459	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	atacacatgggagtcattgtCctttcgccctttctgaaact	7	11	2	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr3:45127459C>T	uc003com.2	-	9	2317	c.2182G>A	c.(2182-2184)GAC>AAC	p.D728N		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	728	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		GAGTCATTGTCCTTTCGCCCT	0.502													T	45127459	T	T	45127459	3	4	268	1	0	0	0	0	1	0	0	0	3093	855	30	3	332	3	CDCP1	3	45127459	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08	4628052	45127459	152894971	12	19206											
SLC15A2	6565	broad.mit.edu	37	chr3	121641692	121641692	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagcactggctagactgggCggctgagaaatatccagtaa	12	9	0	2			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr3:121641692C>T	uc003eep.2	+	9	1004	c.851C>T	c.(850-852)GCG>GTG	p.A284V	SLC15A2_uc011bjn.1_Missense_Mutation_p.A253V	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	284					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CTAGACTGGGCGGCTGAGAAA	0.433													T	121641692	T	T	121641692	3	4	268	1	0	0	0	0	1	0	0	0	14399	768	27	1	885	1	SLC15A2	3	121641692	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08	76514233	121641692	76380738	13	19207											
ILDR1	286676	broad.mit.edu	37	chr3	121712145	121712145	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tctggggctgcctctccttgTcctcttcagagctccaggaa	10	14	4	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr3:121712145T>G	uc003ees.2	-	7	1557	c.1451A>C	c.(1450-1452)GAC>GCC	p.D484A	ILDR1_uc003eeq.2_Missense_Mutation_p.D452A|ILDR1_uc003eer.2_Missense_Mutation_p.D440A|ILDR1_uc010hrg.2_Missense_Mutation_p.D395A	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	484	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		CCTCTCCTTGTCCTCTTCAGA	0.677													G	121712145	G	G	121712145	3	3	268	1	0	0	0	0	1	0	0	0	7709	1667	58	5	197	5	ILDR1	3	121712145	Missense_Mutation	SNP	T	TCGA-76-6193-01A-11D-1696-08	70453	121712145	76310285	14	19208											
PIK3CA	5290	broad.mit.edu	37	chr3	178938803	178938803	+	Frame_Shift_Del	DEL	A	-	-													gcacaataaaacagttagccAgaggtttggcctgcttttgg							TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr3:178938803delA	uc003fjk.2	+	14	2202	c.2045delA	c.(2044-2046)CAGfs	p.Q682fs		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	682	PI3K helical.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ACAGTTAGCCAGAGGTTTGGC	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			-	178938803	-	-	178938803	7	5	268	1	0	1	0	1	0	0	0	0	11913	188	7	0	2095	0	PIK3CA	3	178938803	Frame_Shift_Del	DEL	A	TCGA-76-6193-01A-11D-1696-08	57226658	178938803	19083627	15	19209											
N4BP2	55728	broad.mit.edu	37	chr4	40127847	40127847	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	actgaagactttaacagcatCtgaaatgctacctttattgg	7	8	1	3			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr4:40127847C>T	uc003guy.3	+	12	4762	c.4424C>T	c.(4423-4425)TCT>TTT	p.S1475F	N4BP2_uc010ifq.2_Missense_Mutation_p.S1395F|N4BP2_uc010ifr.2_Missense_Mutation_p.S1395F	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1475						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TTAACAGCATCTGAAATGCTA	0.338													T	40127847	T	T	40127847	3	4	268	1	0	0	0	0	1	0	0	0	10110	913	32	3	4462	3	N4BP2	4	40127847	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08		40127847	151026429	16	19210											
NAA11	84779	broad.mit.edu	37	chr4	80246554	80246554	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcttcaggtccatttgtcGtctcagctcatctgccatct	6	14	6	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr4:80246554G>A	uc003hlt.3	-	1	618	c.478C>T	c.(478-480)CGA>TGA	p.R160*		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	160						cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						TCCATTTGTCGTCTCAGCTCA	0.517													A	80246554	A	A	80246554	4	1	268	1	0	0	0	0	0	1	0	0	10117	1153	40	1	215	1	NAA11	4	80246554	Nonsense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	40118707	80246554	110907722	17	19211											
ANKRD50	57182	broad.mit.edu	37	chr4	125591834	125591834	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttctagcaccttgttcaatAagtgcttcacatatcaatct	5	10	5	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr4:125591834A>G	uc003ifg.3	-	3	2864	c.2598T>C	c.(2596-2598)CTT>CTC	p.L866L	ANKRD50_uc011cgo.1_Silent_p.L687L|ANKRD50_uc010inw.2_Silent_p.L866L	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	866	ANK 12.									central_nervous_system(1)	1						CTTGTTCAATAAGTGCTTCAC	0.393													G	125591834	G	G	125591834	2	3	268	1	0	0	0	0	0	0	0	1	677	349	13	4		4	ANKRD50	4	125591834	Silent	SNP	A	TCGA-76-6193-01A-11D-1696-08	45345280	125591834	65562442	18	19212											
NEIL3	55247	broad.mit.edu	37	chr4	178274739	178274739	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccaagaagacaacaaacgaTataactcaaccatccagcaa	4	12	1	2			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr4:178274739T>G	uc003iut.2	+	8	1434	c.1317T>G	c.(1315-1317)GAT>GAG	p.D439E	NEIL3_uc010irs.2_3'UTR	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	439					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		CAACAAACGATATAACTCAAC	0.373								BER_DNA_glycosylases					G	178274739	G	G	178274739	3	3	268	1	0	0	0	0	1	0	0	0	10320	1403	49	5	1347	5	NEIL3	4	178274739	Missense_Mutation	SNP	T	TCGA-76-6193-01A-11D-1696-08	52682905	178274739	12879537	19	19213											
ATG12	9140	broad.mit.edu	37	chr5	115177234	115177234	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggaagctgcaacacagactGcggctcctccgccatcttgc	10	15	1	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr5:115177234G>A	uc003krh.2	-	1	266	c.157C>T	c.(157-159)CAG>TAG	p.Q53*	AP3S1_uc003krl.2_5'Flank|AP3S1_uc003krk.2_5'Flank|AP3S1_uc003krm.2_5'Flank|ATG12_uc003kri.2_Nonsense_Mutation_p.Q53*|ATG12_uc003krj.2_RNA	NM_004707	NP_004698	O94817	ATG12_HUMAN	APG12 autophagy 12-like	6					autophagic vacuole assembly|negative regulation of type I interferon production	pre-autophagosomal structure membrane	protein binding				0		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;7.59e-08)|Epithelial(69;7.05e-07)|all cancers(49;3.11e-05)		AACACAGACTGCGGCTCCTCC	0.607													A	115177234	A	A	115177234	4	1	268	1	0	0	0	0	0	1	0	0	1090	1328	46	3	422	3	ATG12	5	115177234	Nonsense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08		115177234	65738026	20	19214											
PCDHB10	56126	broad.mit.edu	37	chr5	140573541	140573541	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgccctgcacatcggcagCgtcagcgccacagacagaga	11	17	1	2	rs17844565	byFrequency	TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr5:140573541C>T	uc003lix.2	+	1	1590	c.1416C>T	c.(1414-1416)AGC>AGT	p.S472S		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	472	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACATCGGCAGCGTCAGCGCCA	0.662													T	140573541	T	T	140573541	2	4	268	1	0	0	0	0	0	0	0	1	11535	767	27	1		1	PCDHB10	5	140573541	Silent	SNP	C	TCGA-76-6193-01A-11D-1696-08	25396307	140573541	40341719	21	19215											
ZUFSP	221302	broad.mit.edu	37	chr6	116987896	116987896	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tccacagaatggacattcagGaggactgtatgttgtttcat	10	7	2	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr6:116987896G>T	uc003pxf.1	-	2	706	c.460C>A	c.(460-462)CCT>ACT	p.P154T	ZUFSP_uc010kef.1_Intron	NM_145062	NP_659499	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	154	C2H2-type 2.					intracellular	zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		GGACATTCAGGAGGACTGTAT	0.378													T	116987896	T	T	116987896	3	4	268	1	0	0	0	0	1	0	0	0	18243	1174	41	5	1312	5	ZUFSP	6	116987896	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08		116987896	54127171	22	19216											
LAMA2	3908	broad.mit.edu	37	chr6	129573419	129573419	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctacaaatcacatacagctTtgggatggatgccatcttca	7	11	3	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr6:129573419T>C	uc003qbn.2	+	14	2180	c.2075T>C	c.(2074-2076)TTT>TCT	p.F692S	LAMA2_uc003qbo.2_Missense_Mutation_p.F692S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	692	Laminin IV type A 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ACATACAGCTTTGGGATGGAT	0.453													C	129573419	C	C	129573419	3	2	268	1	0	0	0	0	1	0	0	0	8606	1841	64	4	2129	4	LAMA2	6	129573419	Missense_Mutation	SNP	T	TCGA-76-6193-01A-11D-1696-08	12585523	129573419	41541648	23	19217											
PLXNA4	91584	broad.mit.edu	37	chr7	131982916	131982916	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gccatatcccggaggactggGccggggtccaccacctgcac	13	16	0	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr7:131982916G>T	uc003vra.3	-	4	1666	c.1437C>A	c.(1435-1437)GGC>GGA	p.G479G		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	479	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GGAGGACTGGGCCGGGGTCCA	0.582													T	131982916	T	T	131982916	2	4	268	1	0	0	0	0	0	0	0	1	12122	1190	42	5		5	PLXNA4	7	131982916	Silent	SNP	G	TCGA-76-6193-01A-11D-1696-08		131982916	27155747	24	19218											
DLGAP2	9228	broad.mit.edu	37	chr8	1574988	1574988	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actacaactccccgaaattcCgctcccggaaccagagctac	6	17	0	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr8:1574988C>T	uc003wpl.2	+	4	1382	c.1285C>T	c.(1285-1287)CGC>TGC	p.R429C	DLGAP2_uc003wpm.2_Missense_Mutation_p.R429C	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	508					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CCCGAAATTCCGCTCCCGGAA	0.617													T	1574988	T	T	1574988	3	4	268	1	0	0	0	0	1	0	0	0	4560	652	23	2	1295	2	DLGAP2	8	1574988	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08		1574988	144789034	25	19219											
MPDZ	8777	broad.mit.edu	37	chr9	13162794	13162794	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctgcaggcacataagtaatTctggaacaaaccagaatcca	7	10	2	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr9:13162794T>C	uc010mia.1	-	22	3312	c.3255A>G	c.(3253-3255)AAA>AAG	p.K1085K	MPDZ_uc010mhx.2_5'UTR|MPDZ_uc011lmm.1_5'UTR|MPDZ_uc003zkz.3_Intron|MPDZ_uc010mhy.2_Silent_p.K1085K|MPDZ_uc010mhz.2_Silent_p.K1085K|MPDZ_uc011lmn.1_Silent_p.K1085K|MPDZ_uc003zlb.3_Silent_p.K1085K	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1085	PDZ 6.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CATAAGTAATTCTGGAACAAA	0.348													C	13162794	C	C	13162794	2	2	268	1	0	0	0	0	0	0	0	1	9722	1797	62	4		4	MPDZ	9	13162794	Silent	SNP	T	TCGA-76-6193-01A-11D-1696-08		13162794	128050637	26	19220											
ITGA8	8516	broad.mit.edu	37	chr10	15590502	15590502	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacctgactttcaggactgcGctttctcctccttcgagtcg	9	14	2	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr10:15590502G>A	uc001ioc.1	-	27	2832	c.2832C>T	c.(2830-2832)AGC>AGT	p.S944S	ITGA8_uc010qcb.1_Silent_p.S929S	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	944	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TCAGGACTGCGCTTTCTCCTC	0.483													A	15590502	A	A	15590502	2	1	268	1	0	0	0	0	0	0	0	1	7882	1078	38	1		1	ITGA8	10	15590502	Silent	SNP	G	TCGA-76-6193-01A-11D-1696-08		15590502	119944245	27	19221											
PLCE1	51196	broad.mit.edu	37	chr10	95791394	95791394	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatgaagttgacagaagaatGtcagacactttctgtaccct	8	8	2	5			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr10:95791394G>A	uc001kjk.2	+	2	1225	c.591G>A	c.(589-591)ATG>ATA	p.M197I	PLCE1_uc010qnx.1_Missense_Mutation_p.M197I	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	197					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ACAGAAGAATGTCAGACACTT	0.408													A	95791394	A	A	95791394	3	1	268	1	0	0	0	0	1	0	0	0	12034	1377	48	3	593	3	PLCE1	10	95791394	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	80200892	95791394	39743353	28	19222											
KIAA1598	57698	broad.mit.edu	37	chr10	118689505	118689505	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttttctagttgctcttctaaTtctttgacctataagttatt	4	7	4	1	rs145640256		TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr10:118689505T>A	uc009xyw.2	-	10	1365	c.867A>T	c.(865-867)GAA>GAT	p.E289D	KIAA1598_uc001lcz.3_Missense_Mutation_p.E289D|KIAA1598_uc010qso.1_Missense_Mutation_p.E229D|KIAA1598_uc010qsp.1_Missense_Mutation_p.E289D|KIAA1598_uc010qsq.1_Missense_Mutation_p.E229D|KIAA1598_uc001lcy.3_Missense_Mutation_p.E259D	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	289	Potential.				axon guidance	axon					0				all cancers(201;0.00494)		GCTCTTCTAATTCTTTGACCT	0.308													A	118689505	A	A	118689505	3	1	268	1	0	0	0	0	1	0	0	0	8246	1490	52	5	1060	5	KIAA1598	10	118689505	Missense_Mutation	SNP	T	TCGA-76-6193-01A-11D-1696-08	22898111	118689505	16845242	29	19223											
OR5D16	390144	broad.mit.edu	37	chr11	55606593	55606593	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctatttgcggtgatggcctaTgaccactttgtggccatttg	11	9	0	2			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr11:55606593T>A	uc010rio.1	+	1	366	c.366T>A	c.(364-366)TAT>TAA	p.Y122*		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	122	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				TGATGGCCTATGACCACTTTG	0.433													A	55606593	A	A	55606593	4	1	268	1	0	0	0	0	0	1	0	0	11156	1471	51	5	368	5	OR5D16	11	55606593	Nonsense_Mutation	SNP	T	TCGA-76-6193-01A-11D-1696-08		55606593	79399923	30	19224											
LRRIQ1	84125	broad.mit.edu	37	chr12	85466877	85466877	+	Splice_Site	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcccacttatactggaattGtaagttgtgtttatttttta	6	6	0	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr12:85466877G>T	uc001tac.2	+	11	2998	c.2887_splice	c.e11+1	p.C963_splice	LRRIQ1_uc001tab.1_Splice_Site_p.C963_splice	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1											ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TACTGGAATTGTAAGttgtgt	0.189													T	85466877	T	T	85466877	5	4	268	1	0	0	0	0	0	0	1	0	9029	1391	48	5	2926	5	LRRIQ1	12	85466877	Splice_Site	SNP	G	TCGA-76-6193-01A-11D-1696-08		85466877	48385018	31	19225											
NOS1	4842	broad.mit.edu	37	chr12	117723943	117723943	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actggatcctgcccacacagCgcgaggcattccgccaggcg	12	16	0	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr12:117723943C>T	uc001twm.1	-	6	1942	c.1256G>A	c.(1255-1257)CGC>CAC	p.R419H		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	419					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GCCCACACAGCGCGAGGCATT	0.557													T	117723943	T	T	117723943	3	4	268	1	0	0	0	0	1	0	0	0	10541	768	27	1	3144	1	NOS1	12	117723943	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08	32257066	117723943	16127952	32	19226											
ACADS	35	broad.mit.edu	37	chr12	121164991	121164991	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acatctcttcccagcggctcAggtgagagtgcaacctcagc	10	14	3	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr12:121164991A>G	uc001tza.3	+	2	327	c.209A>G	c.(208-210)CAG>CGG	p.Q70R	ACADS_uc010szl.1_Missense_Mutation_p.Q70R	NM_000017	NP_000008	P16219	ACADS_HUMAN	short-chain acyl-CoA dehydrogenase precursor	70						mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(2)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	CCAGCGGCTCAGGTGAGAGTG	0.567													G	121164991	G	G	121164991	3	3	268	1	0	0	0	0	1	0	0	0	114	202	7	4	215	4	ACADS	12	121164991	Missense_Mutation	SNP	A	TCGA-76-6193-01A-11D-1696-08	3441048	121164991	12686904	33	19227											
RB1	5925	broad.mit.edu	37	chr13	49039379	49039379	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atacctcacattcctcgaagCccttacaagtttcctagttc	4	14	1	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr13:49039379C>T	uc001vcb.2	+	23	2530	c.2364C>T	c.(2362-2364)AGC>AGT	p.S788S		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	788	Interaction with LIMD1.|Domain C; mediates interaction with E4F1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTCCTCGAAGCCCTTACAAGT	0.403		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			T	49039379	T	T	49039379	2	4	268	1	0	0	0	0	0	0	0	1	13098	738	26	3		3	RB1	13	49039379	Silent	SNP	C	TCGA-76-6193-01A-11D-1696-08		49039379	66130499	34	19228											
C13orf34	79866	broad.mit.edu	37	chr13	73321201	73321201	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aactctcatatgtgcatgtcAcctcttgctgaaagcagtgt	8	10	3	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr13:73321201A>G	uc001viv.1	+	10	1553	c.1434A>G	c.(1432-1434)TCA>TCG	p.S478S	C13orf34_uc010thq.1_Silent_p.S253S|C13orf34_uc010aen.1_Silent_p.S553S|C13orf34_uc010thr.1_Silent_p.S408S|C13orf34_uc001viw.1_Silent_p.S427S	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	478					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		TGTGCATGTCACCTCTTGCTG	0.413													G	73321201	G	G	73321201	2	3	268	1	0	0	0	0	0	0	0	1	1728	146	6	4		4	C13orf34	13	73321201	Silent	SNP	A	TCGA-76-6193-01A-11D-1696-08	24281822	73321201	41848677	35	19229											
PYGO1	26108	broad.mit.edu	37	chr15	55838924	55838927	+	Frame_Shift_Del	DEL	TGAC	-	-													tagcattctgtggaggaattTgactgaaattttcagcagga							TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr15:55838924_55838927delTGAC	uc010bfl.1	-	3	610_613	c.554_557delGTCA	c.(553-558)AGTCAAfs	p.S185fs	PYGO1_uc002adf.1_Frame_Shift_Del_p.S185fs	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	185_186	Asn-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		TGGAGGAATTTGACTGAAATTTTC	0.333													-	55838927	-	-	55838924	7	5	268	1	0	1	0	1	0	0	0	0	12863	1812	63	0	706	0	PYGO1	15	55838924	Frame_Shift_Del	DEL	TGAC	TCGA-76-6193-01A-11D-1696-08		55838924	46692468	36	19230											
MAPK3	5595	broad.mit.edu	37	chr16	30128054	30128054	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagatgagctccttcagccGctccttaggtaggtcatcca	10	12	2	2			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr16:30128054G>A	uc002dws.2	-	8	1175	c.1075C>T	c.(1075-1077)CGG>TGG	p.R359W	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_Missense_Mutation_p.R245W|MAPK3_uc002dwv.3_Missense_Mutation_p.R315W|MAPK3_uc002dwt.2_3'UTR|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_RNA	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	359					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding	p.R359W(1)			0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	TCCTTCAGCCGCTCCTTAGGT	0.642													A	30128054	A	A	30128054	3	1	268	1	0	0	0	0	1	0	0	0	9279	1086	38	1	68	1	MAPK3	16	30128054	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08		30128054	60226699	37	19231											
SLC12A3	6559	broad.mit.edu	37	chr16	56913524	56913524	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggggccaccctctcctctgCcctggcctgccttgtctctg	10	19	3	0	rs139743444	byFrequency	TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr16:56913524C>T	uc010ccm.2	+	11	1435	c.1406C>T	c.(1405-1407)GCC>GTC	p.A469V	SLC12A3_uc002ekd.3_Missense_Mutation_p.A469V|SLC12A3_uc010ccn.2_Missense_Mutation_p.A468V	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	469	Helical; (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	CTCTCCTCTGCCCTGGCCTGC	0.632													T	56913524	T	T	56913524	3	4	268	1	0	0	0	0	1	0	0	0	14384	739	26	3	1448	3	SLC12A3	16	56913524	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08	26785470	56913524	33441229	38	19232											
C17orf85	55421	broad.mit.edu	37	chr17	3721586	3721586	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcaactgagattccacttcGtcagcatacatagtcatttt	5	10	3	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr17:3721586G>A	uc010ckl.1	-	10	1304	c.1281C>T	c.(1279-1281)GAC>GAT	p.D427D	C17orf85_uc002fwr.2_Silent_p.D137D|C17orf85_uc002fwq.2_Silent_p.D147D	NM_001114118	NP_001107590	Q53F19	CQ085_HUMAN	ELG protein isoform a	427							nucleotide binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		ATTCCACTTCGTCAGCATACA	0.328													A	3721586	A	A	3721586	2	1	268	1	0	0	0	0	0	0	0	1	1888	1136	40	1		1	C17orf85	17	3721586	Silent	SNP	G	TCGA-76-6193-01A-11D-1696-08		3721586	77473624	39	19233											
TP53	7157	broad.mit.edu	37	chr17	7577551	7577551	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcctccggttcatgccgcCcatgcaggaactgttacaca	11	14	1	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr17:7577551C>T	uc002gim.2	-	7	924	c.730G>A	c.(730-732)GGC>AGC	p.G244S	TP53_uc002gig.1_Missense_Mutation_p.G244S|TP53_uc002gih.2_Missense_Mutation_p.G244S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G112S|TP53_uc010cng.1_Missense_Mutation_p.G112S|TP53_uc002gii.1_Missense_Mutation_p.G112S|TP53_uc010cnh.1_Missense_Mutation_p.G244S|TP53_uc010cni.1_Missense_Mutation_p.G244S|TP53_uc002gij.2_Missense_Mutation_p.G244S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G151S|TP53_uc002gio.2_Missense_Mutation_p.G112S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	244	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> A (in sporadic cancers; somatic mutation).|G -> S (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|MG -> IC (in a sporadic cancer; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> C (in sporadic cancers; somatic mutation).|MG -> IS (in a sporadic cancer; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G244C(36)|p.G244S(35)|p.G244D(32)|p.G244V(14)|p.G244G(13)|p.G244A(9)|p.0?(7)|p.G244fs*3(5)|p.G244R(3)|p.M243_G244>IC(1)|p.G244E(1)|p.G244fs*19(1)|p.G151C(1)|p.G244fs*17(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.C242_M246>L(1)|p.G244del(1)|p.C238_M246delCNSSCMGGM(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCATGCCGCCCATGCAGGAA	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7577551	T	T	7577551	3	4	268	1	0	0	0	0	1	0	0	0	16378	623	22	3	560	3	TP53	17	7577551	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08	3855965	7577551	73617659	40	19234											
TP53	7157	broad.mit.edu	37	chr17	7578464	7578464	+	Missense_Mutation	SNP	G	A	A													gatggccatggcgcggacgcGggtgccgggcgggggtgtgg							TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr17:7578464G>A	uc002gim.2	-	5	660	c.466C>T	c.(466-468)CGC>TGC	p.R156C	TP53_uc002gig.1_Missense_Mutation_p.R156C|TP53_uc002gih.2_Missense_Mutation_p.R156C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R24C|TP53_uc010cng.1_Missense_Mutation_p.R24C|TP53_uc002gii.1_Missense_Mutation_p.R24C|TP53_uc010cnh.1_Missense_Mutation_p.R156C|TP53_uc010cni.1_Missense_Mutation_p.R156C|TP53_uc002gij.2_Missense_Mutation_p.R156C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R63C|TP53_uc002gio.2_Missense_Mutation_p.R24C|TP53_uc010vug.1_Missense_Mutation_p.R117C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	156	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R156P(24)|p.R156H(10)|p.R156fs*14(8)|p.0?(7)|p.R156S(3)|p.R156R(3)|p.R156fs*25(3)|p.P152fs*14(3)|p.R156G(3)|p.R156L(3)|p.G154fs*14(2)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.P153fs*22(2)|p.R156C(2)|p.T155_R156delTR(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156del(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.G154_R156delGTR(1)|p.R156fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCGGACGCGGGTGCCGGGC	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7578464	A	A	7578464	3	1	268	1	0	0	0	0	1	0	0	0	16378	1116	39	2	832	2	TP53	17	7578464	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	913	7578464	73616746	41	19235	25	2									
TP53	7157	broad.mit.edu	37	chr17	7578466	7578466	+	Missense_Mutation	SNP	G	T	T													tggccatggcgcggacgcggGtgccgggcgggggtgtggaa							TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr17:7578466G>T	uc002gim.2	-	5	658	c.464C>A	c.(463-465)ACC>AAC	p.T155N	TP53_uc002gig.1_Missense_Mutation_p.T155N|TP53_uc002gih.2_Missense_Mutation_p.T155N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.T23N|TP53_uc010cng.1_Missense_Mutation_p.T23N|TP53_uc002gii.1_Missense_Mutation_p.T23N|TP53_uc010cnh.1_Missense_Mutation_p.T155N|TP53_uc010cni.1_Missense_Mutation_p.T155N|TP53_uc002gij.2_Missense_Mutation_p.T155N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.T62N|TP53_uc002gio.2_Missense_Mutation_p.T23N|TP53_uc010vug.1_Missense_Mutation_p.T116N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	155	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|T -> S (in sporadic cancers; somatic mutation).|T -> P (in sporadic cancers; somatic mutation).|T -> A (in sporadic cancers; somatic mutation).|T -> I (in sporadic cancers; somatic mutation).|T -> M (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T155N(19)|p.T155P(14)|p.T155I(10)|p.0?(7)|p.T155A(7)|p.T155T(5)|p.P152fs*14(3)|p.G154fs*14(2)|p.T155fs*23(2)|p.P153fs*22(2)|p.T155S(2)|p.P151_V173del23(1)|p.G154_R156delGTR(1)|p.T155fs*26(1)|p.T155fs*25(1)|p.R156_A161del(1)|p.D148_T155delDSTPPPGT(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.T155fs*15(1)|p.R156fs*25(1)|p.T155_R156delTR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGGACGCGGGTGCCGGGCGG	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578466	T	T	7578466	3	4	268	1	0	0	0	0	1	0	0	0	16378	1261	44	5	834	5	TP53	17	7578466	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	2	7578466	73616744	42	19236	25	2									
ALOX15B	247	broad.mit.edu	37	chr17	7942479	7942479	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttaggctggcagcatggcCgagttcagggtcagggtgtc	16	9	2	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr17:7942479C>T	uc002gju.2	+	1	122	c.6C>T	c.(4-6)GCC>GCT	p.A2A	ALOX15B_uc002gjv.2_Silent_p.A2A|ALOX15B_uc002gjw.2_Silent_p.A2A|ALOX15B_uc010vun.1_Silent_p.A2A|ALOX15B_uc010cnp.2_5'UTR	NM_001141	NP_001132	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, second type	2	PLAT.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1						GCAGCATGGCCGAGTTCAGGG	0.652													T	7942479	T	T	7942479	2	4	268	1	0	0	0	0	0	0	0	1	539	639	23	2		2	ALOX15B	17	7942479	Silent	SNP	C	TCGA-76-6193-01A-11D-1696-08	364013	7942479	73252731	43	19237											
BPTF	2186	broad.mit.edu	37	chr17	65924656	65924656	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccagctacagtaacattccaAcaaaacaagaactttcatca	3	12	2	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr17:65924656A>G	uc002jgf.2	+	16	5998	c.5937A>G	c.(5935-5937)CAA>CAG	p.Q1979Q	BPTF_uc002jge.2_Silent_p.Q2105Q	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2105					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TAACATTCCAACAAAACAAGA	0.393													G	65924656	G	G	65924656	2	3	268	1	0	0	0	0	0	0	0	1	1495	40	2	4		4	BPTF	17	65924656	Silent	SNP	A	TCGA-76-6193-01A-11D-1696-08	57982177	65924656	15270554	44	19238											
TMEM146	257062	broad.mit.edu	37	chr19	5739352	5739352	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tatagcatgtcagtaatttgGtttttgcatatttccgtgga	9	5	1	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr19:5739352G>C	uc002mda.2	+	7	536	c.475G>C	c.(475-477)GTT>CTT	p.V159L	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	159	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAGTAATTTGGTTTTTGCATA	0.214													C	5739352	C	C	5739352	3	2	268	1	0	0	0	0	1	0	0	0	16057	1261	44	5	501	5	TMEM146	19	5739352	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08		5739352	53389631	45	19239											
MUC16	94025	broad.mit.edu	37	chr19	9049260	9049260	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaccattgaggtcaccaaccGtgatacagcaggcgagatag	12	10	1	3			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr19:9049260G>A	uc002mkp.2	-	5	32575	c.32371C>T	c.(32371-32373)CGG>TGG	p.R10791W		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10793	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCACCAACCGTGATACAGCA	0.483													A	9049260	A	A	9049260	3	1	268	1	0	0	0	0	1	0	0	0	9973	1144	40	1	11472	1	MUC16	19	9049260	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	3309908	9049260	50079723	46	19240											
CASP14	23581	broad.mit.edu	37	chr19	15164396	15164396	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgctctggaacacatgtttcGgcagctgagattcgaaagca	11	9	1	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr19:15164396G>T	uc010dzv.1	+	3	439	c.131G>T	c.(130-132)CGG>CTG	p.R44L	CASP14_uc002naf.2_Missense_Mutation_p.R44L	NM_012114	NP_036246	P31944	CASPE_HUMAN	caspase 14 precursor	44					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			skin(2)|ovary(1)|lung(1)	4						CACATGTTTCGGCAGCTGAGA	0.527													T	15164396	T	T	15164396	3	4	268	1	0	0	0	0	1	0	0	0	2670	1116	39	5	137	5	CASP14	19	15164396	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	6115136	15164396	43964587	47	19241											
PPFIA3	8541	broad.mit.edu	37	chr19	49651354	49651354	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccccagatcctggcatatggCgacatgaaccacgagtgggt	12	12	0	2			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr19:49651354C>T	uc002pmr.2	+	24	3182	c.2850C>T	c.(2848-2850)GGC>GGT	p.G950G	PPFIA3_uc010yai.1_RNA|PPFIA3_uc002pms.2_Silent_p.G809G|PPFIA3_uc002pmt.2_Silent_p.G89G|PPFIA3_uc002pmu.1_5'UTR	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	950						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		TGGCATATGGCGACATGAACC	0.617													T	49651354	T	T	49651354	2	4	268	1	0	0	0	0	0	0	0	1	12311	755	27	1		1	PPFIA3	19	49651354	Silent	SNP	C	TCGA-76-6193-01A-11D-1696-08	34486958	49651354	9477629	48	19242											
PDYN	5173	broad.mit.edu	37	chr20	1961151	1961151	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcatggcccatgctatcccCgtccccctccccagccacct	5	23	1	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr20:1961151C>T	uc010gaj.2	-	3	825	c.583G>A	c.(583-585)GGG>AGG	p.G195R	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.G195R|PDYN_uc010zpt.1_Missense_Mutation_p.G40R	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	195					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						ATGCTATCCCCGTCCCCCTCC	0.597													T	1961151	T	T	1961151	3	4	268	1	0	0	0	0	1	0	0	0	11699	652	23	2	185	2	PDYN	20	1961151	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08		1961151	61064369	49	19243											
RALGAPA2	57186	broad.mit.edu	37	chr20	20493649	20493649	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ttactctcacatcagagagaGagcccactggtgatccccct	8	14	2	3			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr20:20493649G>C	uc002wrz.2	-	32	4507	c.4364C>G	c.(4363-4365)TCT>TGT	p.S1455C	RALGAPA2_uc010gcx.2_Missense_Mutation_p.S1159C|RALGAPA2_uc010zsg.1_Missense_Mutation_p.S903C|RALGAPA2_uc002wsa.1_Missense_Mutation_p.S227C	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1455					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						ATCAGAGAGAGAGCCCACTGG	0.478													C	20493649	C	C	20493649	3	2	268	1	0	0	0	0	1	0	0	0	13014	942	33	5	1289	5	RALGAPA2	20	20493649	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	18532498	20493649	42531871	50	19244											
RALGAPB	57148	broad.mit.edu	37	chr20	37182634	37182634	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctgacccagttacggattGcaagcccccgcctcctgccc	8	19	0	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr20:37182634G>A	uc002xiw.2	+	22	3544	c.3287G>A	c.(3286-3288)TGC>TAC	p.C1096Y	RALGAPB_uc002xix.2_Missense_Mutation_p.C1092Y|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.C874Y	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1096					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						GTTACGGATTGCAAGCCCCCG	0.478													A	37182634	A	A	37182634	3	1	268	1	0	0	0	0	1	0	0	0	13015	1319	46	3	3369	3	RALGAPB	20	37182634	Missense_Mutation	SNP	G	TCGA-76-6193-01A-11D-1696-08	16688985	37182634	25842886	51	19245											
LAMA5	3911	broad.mit.edu	37	chr20	60911477	60911477	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctcggcccctccacgtgagCccggcacatacagggaacct	11	17	0	1			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr20:60911477C>T	uc002ycq.2	-	18	2309	c.2242G>A	c.(2242-2244)GCT>ACT	p.A748T		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	748	Laminin EGF-like 9.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCCACGTGAGCCCGGCACATA	0.642													T	60911477	T	T	60911477	3	4	268	1	0	0	0	0	1	0	0	0	8609	739	26	3	9097	3	LAMA5	20	60911477	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08	23728843	60911477	2114043	52	19246											
APOBEC3F	200316	broad.mit.edu	37	chr22	39448100	39448100	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	tggatcctgagacccattgtCatgcagaaaggtgcttcctc	10	11	1	2			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chr22:39448100C>A	uc003aww.2	+	6	1038	c.745C>A	c.(745-747)CAT>AAT	p.H249N		NM_145298	NP_660341	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	257		Zinc (By similarity).		H->A: Decreases cytidine deaminase activity.	base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding				0	Melanoma(58;0.04)					GACCCATTGTCATGCAGAAAG	0.572													A	39448100	A	A	39448100	3	1	268	1	0	0	0	0	1	0	0	0	793	826	29	5	906	5	APOBEC3F	22	39448100	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08		39448100	11856466	53	19247											
DCAF12L1	139170	broad.mit.edu	37	chrX	125685588	125685588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggatgttctgctggtcctggCgcagatccaggaaagagacg	15	9	1	2			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chrX:125685588C>T	uc004eul.2	-	1	1255	c.1004G>A	c.(1003-1005)CGC>CAC	p.R335H		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	335										skin(3)|ovary(1)	4						CTGGTCCTGGCGCAGATCCAG	0.597													T	125685588	T	T	125685588	3	4	268	1	0	0	0	0	1	0	0	0	4264	768	27	1	391	1	DCAF12L1	23	125685588	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08		125685588	29584972	54	19248											
VAMP7	6845	broad.mit.edu	37	chrX	155169439	155169439	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	aacctcaagctcactattatCatcatcatcgtatcaattgt	3	11	6	0			TCGA-76-6193-01A-11D-1696-08	TCGA-76-6193-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a751d65-5fcf-4c03-8253-8f1b8faccab2	2c173733-933e-408a-b54b-ded5dffc589e	g.chrX:155169439C>G	uc004fnr.2	+	7	750	c.576C>G	c.(574-576)ATC>ATG	p.I192M	VAMP7_uc004fnt.2_Missense_Mutation_p.I151M|VAMP7_uc011naa.1_Missense_Mutation_p.I153M|VAMP7_uc011nab.1_Missense_Mutation_p.I91M|VAMP7_uc004fns.2_Missense_Mutation_p.H170D|VAMP7_uc011nac.1_Missense_Mutation_p.I125M	NM_005638	NP_005629	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7 isoform 1	192	Helical; Anchor for type IV membrane protein; (Potential).				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TCACTATTATCATCATCATCG	0.333													G	155169439	G	G	155169439	3	3	268	1	0	0	0	0	1	0	0	0	17114	826	29	5	598	5	VAMP7	23	155169439	Missense_Mutation	SNP	C	TCGA-76-6193-01A-11D-1696-08	29483851	155169439	101121	55	19249											
CYP4B1	1580	broad.mit.edu	37	chr1	47282802	47282802	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacctgtgccccaggtgtacCgccagctcagcaagcctgtc	10	17	1	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr1:47282802C>T	uc001cqm.3	+	9	1237	c.1153C>T	c.(1153-1155)CGC>TGC	p.R385C	CYP4B1_uc001cqn.3_Missense_Mutation_p.R386C|CYP4B1_uc009vym.2_Missense_Mutation_p.R371C|CYP4B1_uc010omk.1_Missense_Mutation_p.R222C	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	385					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CCAGGTGTACCGCCAGCTCAG	0.572													T	47282802	T	T	47282802	3	4	269	1	0	0	0	0	1	0	0	0	4185	652	23	2	1190	2	CYP4B1	1	47282802	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08		47282802	201967819	1	19250											
PLXNA2	5362	broad.mit.edu	37	chr1	208269395	208269395	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gttggtgggcactgcagttgTaaaacttgaactcggtgctg	14	7	0	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr1:208269395T>G	uc001hgz.2	-	8	2719	c.1961A>C	c.(1960-1962)TAC>TCC	p.Y654S		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	654	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ACTGCAGTTGTAAAACTTGAA	0.393													G	208269395	G	G	208269395	3	3	269	1	0	0	0	0	1	0	0	0	12120	1638	57	5	3823	5	PLXNA2	1	208269395	Missense_Mutation	SNP	T	TCGA-76-6280-01A-21D-1845-08	160986593	208269395	40981226	2	19251											
POTEF	728378	broad.mit.edu	37	chr2	130878084	130878084	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gcatggaatcaacctcaaccAccatctgcttttaacagcca	5	14	3	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr2:130878084A>C	uc010fmh.2	-	3	405	c.5T>G	c.(4-6)GTG>GGG	p.V2G		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	2						cell cortex	ATP binding			skin(3)|ovary(2)	5						AACCTCAACCACCATCTGCTT	0.532													C	130878084	C	C	130878084	3	2	269	1	0	0	0	0	1	0	0	0	12265	159	6	5	3282	5	POTEF	2	130878084	Missense_Mutation	SNP	A	TCGA-76-6280-01A-21D-1845-08		130878084	112321289	3	19252											
PRPF40A	55660	broad.mit.edu	37	chr2	153514467	153514467	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgatctttgtctagttctgTctttttcactttcccgatct	5	11	6	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr2:153514467T>C	uc002tyh.3	-	25	2658	c.2636A>G	c.(2635-2637)GAC>GGC	p.D879G	PRPF40A_uc002tyg.3_Missense_Mutation_p.D335G|PRPF40A_uc010zcd.1_Missense_Mutation_p.D830G	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	906					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						TCTAGTTCTGTCTTTTTCACT	0.348													C	153514467	C	C	153514467	3	2	269	1	0	0	0	0	1	0	0	0	12571	1667	58	4	164	4	PRPF40A	2	153514467	Missense_Mutation	SNP	T	TCGA-76-6280-01A-21D-1845-08	22636383	153514467	89684906	4	19253											
CASP10	843	broad.mit.edu	37	chr2	202074219	202074219	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccaggctatgtatcctttcGgcatgtggaggaaggcagct	13	10	0	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr2:202074219G>A	uc002uxl.1	+	9	1767	c.1349G>A	c.(1348-1350)CGG>CAG	p.R450Q	CASP10_uc002uxj.1_Missense_Mutation_p.R450Q|CASP10_uc002uxk.1_Missense_Mutation_p.R407Q|CASP10_uc010fta.1_Missense_Mutation_p.R383Q|CASP10_uc002uxm.1_Missense_Mutation_p.R407Q|CASP10_uc010ftb.1_RNA	NM_032974	NP_116756	Q92851	CASPA_HUMAN	caspase 10 isoform b preproprotein	450					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6						GTATCCTTTCGGCATGTGGAG	0.488													A	202074219	A	A	202074219	3	1	269	1	0	0	0	0	1	0	0	0	2669	1116	39	2	1379	2	CASP10	2	202074219	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	48559752	202074219	41125154	5	19254											
TRIM71	131405	broad.mit.edu	37	chr3	32859711	32859711	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtcgtcggggggcggcggcGggggccctggggcggcggcg	26	12	0	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr3:32859711G>A	uc003cff.2	+	1	202	c.139G>A	c.(139-141)GGG>AGG	p.G47R		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	47	RING-type.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						gggcggcggcgggggccctgg	0.502													A	32859711	A	A	32859711	3	1	269	1	0	0	0	0	1	0	0	0	16541	1116	39	2	141	2	TRIM71	3	32859711	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08		32859711	165162719	6	19255											
C3orf67	200844	broad.mit.edu	37	chr3	58870322	58870322	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gaattttatttcagtttggcGaagtttagtcatgtttagca	9	4	2	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr3:58870322G>A	uc003dkt.1	-	7	698	c.289C>T	c.(289-291)CGC>TGC	p.R97C	uc003dku.1_Intron|C3orf67_uc003dkv.1_5'UTR|C3orf67_uc003dkw.2_Missense_Mutation_p.R5C	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	97											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		TCAGTTTGGCGAAGTTTAGTC	0.353													A	58870322	A	A	58870322	3	1	269	1	0	0	0	0	1	0	0	0	2241	1058	37	2	1442	2	C3orf67	3	58870322	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	26010611	58870322	139152108	7	19256											
ROBO2	6092	broad.mit.edu	37	chr3	77629222	77629222	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggtagaggttgcagctagtaCcagtgcaggggttggagtaa	17	5	0	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr3:77629222C>A	uc003dpy.3	+	16	3096	c.2453C>A	c.(2452-2454)ACC>AAC	p.T818N	ROBO2_uc003dpz.2_Missense_Mutation_p.T822N|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.T822N	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	818	Fibronectin type-III 3.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GCAGCTAGTACCAGTGCAGGG	0.453													A	77629222	A	A	77629222	3	1	269	1	0	0	0	0	1	0	0	0	13514	507	18	5	2517	5	ROBO2	3	77629222	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	18758900	77629222	120393208	8	19257											
OR5K4	403278	broad.mit.edu	37	chr3	98073062	98073062	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcgacaatggcctatgaccGctatgtggccatatgccacc	11	13	0	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr3:98073062G>A	uc011bgv.1	+	1	365	c.365G>A	c.(364-366)CGC>CAC	p.R122H		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GCCTATGACCGCTATGTGGCC	0.473													A	98073062	A	A	98073062	3	1	269	1	0	0	0	0	1	0	0	0	11169	1087	38	1	367	1	OR5K4	3	98073062	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	20443840	98073062	99949368	9	19258											
CCDC80	151887	broad.mit.edu	37	chr3	112356885	112356885	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggctacttacaaggagtcttCgtttgccttcaaaggacccc	9	12	2	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr3:112356885C>T	uc003dzf.2	-	2	2086	c.1868G>A	c.(1867-1869)CGA>CAA	p.R623Q	CCDC80_uc011bhv.1_Missense_Mutation_p.R623Q|CCDC80_uc003dzg.2_Missense_Mutation_p.R623Q|CCDC80_uc003dzh.1_Missense_Mutation_p.R623Q	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	623										ovary(2)	2						AAGGAGTCTTCGTTTGCCTTC	0.463													T	112356885	T	T	112356885	3	4	269	1	0	0	0	0	1	0	0	0	2854	884	31	2	1012	2	CCDC80	3	112356885	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	14283823	112356885	85665545	10	19259											
PLXND1	23129	broad.mit.edu	37	chr3	129297231	129297231	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgggagccacccgtaggcaCgggtgccaggggtgagagca	18	11	0	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr3:129297231C>T	uc003emx.2	-	9	2387	c.2287G>A	c.(2287-2289)GTG>ATG	p.V763M		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	763	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CCCGTAGGCACGGGTGCCAGG	0.632													T	129297231	T	T	129297231	3	4	269	1	0	0	0	0	1	0	0	0	12127	536	19	1	3602	1	PLXND1	3	129297231	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	16940346	129297231	68725199	11	19260											
VPS8	23355	broad.mit.edu	37	chr3	184552450	184552450	+	Frame_Shift_Del	DEL	C	-	-													ttttcaggaagaagaaattaCctgattctttttcacttcat							TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr3:184552450delC	uc003fpb.1	+	5	538	c.367delC	c.(367-369)CCTfs	p.P123fs	VPS8_uc010hyd.1_Frame_Shift_Del_p.P123fs|VPS8_uc003fpc.1_Frame_Shift_Del_p.P123fs	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	123							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GAAGAAATTACCTGATTCTTT	0.343													-	184552450	-	-	184552450	7	5	269	1	0	1	0	1	0	0	0	0	17215	507	18	0	381	0	VPS8	3	184552450	Frame_Shift_Del	DEL	C	TCGA-76-6280-01A-21D-1845-08	55255219	184552450	13469980	12	19261											
UGT2B10	7365	broad.mit.edu	37	chr4	69874575	69874575	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aaaaatattgttctactcacGaaggatcattaattactgtc	5	7	3	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr4:69874575G>A	uc011cao.1	-	8	1332	c.1196C>T	c.(1195-1197)TCA>TTA	p.S399L	UGT2B10_uc011can.1_Missense_Mutation_p.S315L			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	436					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TTCTACTCACGAAGGATCATT	0.368													A	69874575	A	A	69874575	3	1	269	1	0	0	0	0	1	0	0	0	16953	1072	37	2	1898	2	UGT2B10	4	69874575	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08		69874575	121279701	13	19262											
NDST4	64579	broad.mit.edu	37	chr4	115891587	115891587	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacaataaaatgtgctcaccAgtgcaaattccttgttgaga	7	9	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr4:115891587A>G	uc003ibu.2	-	4	1899	c.1220T>C	c.(1219-1221)CTG>CCG	p.L407P	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	407	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TGTGCTCACCAGTGCAAATTC	0.383													G	115891587	G	G	115891587	3	3	269	1	0	0	0	0	1	0	0	0	10258	202	7	4	1442	4	NDST4	4	115891587	Missense_Mutation	SNP	A	TCGA-76-6280-01A-21D-1845-08	46017012	115891587	75262689	14	19263											
HEATR7B2	133558	broad.mit.edu	37	chr5	41058293	41058293	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtgggcccgtgggccttaaCgatgctcaaagtctgtacag	13	11	2	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr5:41058293C>T	uc003jmj.3	-	7	1118	c.628G>A	c.(628-630)GTT>ATT	p.V210I	HEATR7B2_uc003jmi.3_5'UTR	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	210							binding			ovary(6)|central_nervous_system(2)	8						TGGGCCTTAACGATGCTCAAA	0.512													T	41058293	T	T	41058293	3	4	269	1	0	0	0	0	1	0	0	0	7035	536	19	1	4273	1	HEATR7B2	5	41058293	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08		41058293	139856967	15	19264											
PIK3R1	5295	broad.mit.edu	37	chr5	67589634	67589635	+	In_Frame_Ins	INS	-	ATATGAAGA	ATATGAAGA													agtcgagaatatgatagattINSatatgaagaatatacccgca							TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr5:67589634_67589635insATATGAAGA	uc003jva.2	+	11	1957_1958	c.1397_1398insATATGAAGA	c.(1396-1398)TTA>TTATATGAAGAA	p.469_470insYEE	PIK3R1_uc003jvb.2_In_Frame_Ins_p.469_470insYEE|PIK3R1_uc003jvc.2_In_Frame_Ins_p.169_170insYEE|PIK3R1_uc003jvd.2_In_Frame_Ins_p.199_200insYEE|PIK3R1_uc003jve.2_In_Frame_Ins_p.148_149insYEE|PIK3R1_uc011crb.1_In_Frame_Ins_p.139_140insYEE	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	469_470					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.Y463_L466del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TATGATAGATTATATGAAGAAT	0.287			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			ATATGAAGA	67589635	ATATGAAGA	ATATGAAGA	67589634	7	5	269	1	0	1	1	0	0	0	0	0	11918	1764	61	0	1565	0	PIK3R1	5	67589634	In_Frame_Ins	INS	-	TCGA-76-6280-01A-21D-1845-08	26531341	67589634	113325626	16	19265											
PKHD1	5314	broad.mit.edu	37	chr6	51491840	51491840	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttgggcccttgtgattctcGgcgtttggatgagatgtgga	15	6	1	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr6:51491840G>A	uc003pah.1	-	66	12016	c.11740C>T	c.(11740-11742)CGA>TGA	p.R3914*		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3914	Cytoplasmic (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TGTGATTCTCGGCGTTTGGAT	0.438													A	51491840	A	A	51491840	4	1	269	1	0	0	0	0	0	1	0	0	11971	1124	39	2	492	2	PKHD1	6	51491840	Nonsense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08		51491840	119623227	17	19266											
PKHD1	5314	broad.mit.edu	37	chr6	51918008	51918008	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctggagatccccgaagcaaCgcacacaagtctcccagagg	11	14	1	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr6:51918008C>T	uc003pah.1	-	21	2282	c.2006G>A	c.(2005-2007)CGT>CAT	p.R669H	PKHD1_uc003pai.2_Missense_Mutation_p.R669H	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	669	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCCGAAGCAACGCACACAAGT	0.582													T	51918008	T	T	51918008	3	4	269	1	0	0	0	0	1	0	0	0	11971	536	19	1	10445	1	PKHD1	6	51918008	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	426168	51918008	119197059	18	19267											
PKHD1	5314	broad.mit.edu	37	chr6	51941107	51941107	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtggataaacttggtgaaCgatgggtgtctgcgccttgg	16	6	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr6:51941107C>T	uc003pah.1	-	6	691	c.415G>A	c.(415-417)GTT>ATT	p.V139I	PKHD1_uc003pai.2_Missense_Mutation_p.V139I	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	139	IPT/TIG 2.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					ACTTGGTGAACGATGGGTGTC	0.393													T	51941107	T	T	51941107	3	4	269	1	0	0	0	0	1	0	0	0	11971	536	19	1	12096	1	PKHD1	6	51941107	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	23099	51941107	119173960	19	19268											
VGLL2	245806	broad.mit.edu	37	chr6	117589651	117589651	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaggagctctgggccctggCgaggtgagtatagggccctg	17	10	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr6:117589651C>T	uc003pxn.2	+	2	578	c.388C>T	c.(388-390)CGA>TGA	p.R130*	VGLL2_uc003pxo.2_Nonsense_Mutation_p.R130*	NM_182645	NP_872586	Q8N8G2	VGLL2_HUMAN	vestigial-like 2 isoform 1	130					transcription, DNA-dependent	nucleus				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(226;0.0254)|all cancers(137;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.0757)		TGGGCCCTGGCGAGGTGAGTA	0.567													T	117589651	T	T	117589651	4	4	269	1	0	0	0	0	0	1	0	0	17156	760	27	1	394	1	VGLL2	6	117589651	Nonsense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	65648544	117589651	53525416	20	19269											
IGF2R	3482	broad.mit.edu	37	chr6	160506085	160506085	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctgggctgctctgaaaggGccagcatttgcagaaggacc	13	12	1	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr6:160506085G>A	uc003qta.2	+	41	6275	c.6127G>A	c.(6127-6129)GCC>ACC	p.A2043T		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	2043	14.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CTCTGAAAGGGCCAGCATTTG	0.517													A	160506085	A	A	160506085	3	1	269	1	0	0	0	0	1	0	0	0	7576	1203	42	3	6289	3	IGF2R	6	160506085	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	42916434	160506085	10608982	21	19270											
ZPBP	11055	broad.mit.edu	37	chr7	50097612	50097612	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcatattttagttgaagacGtttaacaatttcttccacag	6	7	1	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr7:50097612G>A	uc003tou.2	-	4	530	c.460C>T	c.(460-462)CGT>TGT	p.R154C	ZPBP_uc011kci.1_Missense_Mutation_p.R80C|ZPBP_uc010kyw.2_Missense_Mutation_p.R153C	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	154					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					AGTTGAAGACGTTTAACAATT	0.294													A	50097612	A	A	50097612	3	1	269	1	0	0	0	0	1	0	0	0	18216	1145	40	1	615	1	ZPBP	7	50097612	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08		50097612	109041051	22	19271											
NRCAM	4897	broad.mit.edu	37	chr7	107880546	107880546	+	Translation_Start_Site	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agactcacacactgaatttcCttttcttctttcacaaaaga	3	11	4	3			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr7:107880546C>A	uc003vfb.2	-	4	434	c.-37G>T	c.(-39--35)AAGGA>AATGA		NRCAM_uc003vfc.2_Translation_Start_Site|NRCAM_uc011kmk.1_Translation_Start_Site|NRCAM_uc003vfd.2_Translation_Start_Site|NRCAM_uc003vfe.2_Translation_Start_Site	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A						angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						ACTGAATTTCCTTTTCTTCTT	0.383													A	107880546	A	A	107880546	1	1	269	1	0	0	0	0	0	0	0	0	10644	696	24	5		5	NRCAM	7	107880546	Translation_Start_Site	SNP	C	TCGA-76-6280-01A-21D-1845-08	57782934	107880546	51258117	23	19272											
GRM8	2918	broad.mit.edu	37	chr7	126173900	126173900	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcaggctgcagacagacgcCgggtgagtatgttctctatg	15	9	1	3			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr7:126173900C>T	uc003vlr.2	-	8	1847	c.1536G>A	c.(1534-1536)CCG>CCA	p.P512P	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.P512P|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	512	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AGACAGACGCCGGGTGAGTAT	0.488										HNSCC(24;0.065)			T	126173900	T	T	126173900	2	4	269	1	0	0	0	0	0	0	0	1	6803	639	23	2		2	GRM8	7	126173900	Silent	SNP	C	TCGA-76-6280-01A-21D-1845-08	18293354	126173900	32964763	24	19273											
SPTAN1	6709	broad.mit.edu	37	chr9	131381157	131381157	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcctgtaattaggggtcagCggctggaagagtccttggaa	14	8	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr9:131381157C>T	uc004bvl.3	+	43	5706	c.5593C>T	c.(5593-5595)CGG>TGG	p.R1865W	SPTAN1_uc004bvm.3_Missense_Mutation_p.R1870W|SPTAN1_uc004bvn.3_Missense_Mutation_p.R1845W	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1865	Spectrin 19.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TAGGGGTCAGCGGCTGGAAGA	0.423													T	131381157	T	T	131381157	3	4	269	1	0	0	0	0	1	0	0	0	15116	759	27	1	5778	1	SPTAN1	9	131381157	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08		131381157	9832274	25	19274											
CACNA1B	774	broad.mit.edu	37	chr9	140777224	140777224	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggagccctatttcatcgggaTcttttgcttcgaggcaggga	13	9	2	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr9:140777224T>C	uc004cog.2	+	3	564	c.419T>C	c.(418-420)ATC>ACC	p.I140T	uc004cof.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	140	I.|Helical; Name=S2 of repeat I; (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TTCATCGGGATCTTTTGCTTC	0.572													C	140777224	C	C	140777224	3	2	269	1	0	0	0	0	1	0	0	0	2539	1435	50	4	429	4	CACNA1B	9	140777224	Missense_Mutation	SNP	T	TCGA-76-6280-01A-21D-1845-08	9396067	140777224	436207	26	19275											
CACNB2	783	broad.mit.edu	37	chr10	18828173	18828173	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgccagggttctcaaggtgaTcagaggactgatcgctccgc	13	11	2	3			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr10:18828173T>C	uc001ipr.2	+	14	1563	c.1503T>C	c.(1501-1503)GAT>GAC	p.D501D	CACNB2_uc009xjz.1_Silent_p.D251D|CACNB2_uc001ips.2_Silent_p.D477D|CACNB2_uc001ipt.2_Silent_p.D463D|CACNB2_uc001ipu.2_Silent_p.D473D|CACNB2_uc001ipv.2_Silent_p.D449D|CACNB2_uc009xka.1_Silent_p.D435D|CACNB2_uc001ipw.2_Silent_p.D408D|CACNB2_uc001ipx.2_Silent_p.D446D|CACNB2_uc001ipz.2_Silent_p.D423D|CACNB2_uc001ipy.2_Silent_p.D447D|CACNB2_uc010qco.1_Silent_p.D415D|CACNB2_uc001iqa.2_Silent_p.D453D|NSUN6_uc001iqb.2_RNA	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	501				D -> H (in Ref. 3; AAD33729/AAD33730).	axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTCAAGGTGATCAGAGGACTG	0.527													C	18828173	C	C	18828173	2	2	269	1	0	0	0	0	0	0	0	1	2553	1432	50	4		4	CACNB2	10	18828173	Silent	SNP	T	TCGA-76-6280-01A-21D-1845-08		18828173	116706574	27	19276											
ACTA2	59	broad.mit.edu	37	chr10	90707027	90707027	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccataccttttccatgtcGtcccagttggtgatgatgcc	8	13	0	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr10:90707027G>A	uc001kfp.2	-	3	362	c.246C>T	c.(244-246)GAC>GAT	p.D82D	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Silent_p.D37D|ACTA2_uc001kfq.2_Silent_p.D82D|ACTA2_uc010qmz.1_Silent_p.D82D	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	82					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		TTTCCATGTCGTCCCAGTTGG	0.502													A	90707027	A	A	90707027	2	1	269	1	0	0	0	0	0	0	0	1	192	1136	40	1		1	ACTA2	10	90707027	Silent	SNP	G	TCGA-76-6280-01A-21D-1845-08	71878854	90707027	44827720	28	19277											
HTR7	3363	broad.mit.edu	37	chr10	92616992	92616992	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtgtccaaagatccacttgCccccgatgaggtcggtgacg	12	12	0	3			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr10:92616992C>T	uc001kha.2	-	1	680	c.437G>A	c.(436-438)GGC>GAC	p.G146D	HTR7_uc001kgz.2_Missense_Mutation_p.G146D|HTR7_uc001khb.2_Missense_Mutation_p.G146D	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	146	Extracellular (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	GATCCACTTGCCCCCGATGAG	0.592													T	92616992	T	T	92616992	3	4	269	1	0	0	0	0	1	0	0	0	7452	739	26	3	1022	3	HTR7	10	92616992	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	1909965	92616992	42917755	29	19278											
OR52N1	79473	broad.mit.edu	37	chr11	5809262	5809262	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtcccccaaaatggtgtgtaAagaaggtaaagaaggctgga	13	6	0	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr11:5809262A>G	uc010qzo.1	-	1	785	c.785T>C	c.(784-786)TTT>TCT	p.F262S	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ATGGTGTGTAAAGAAGGTAAA	0.453													G	5809262	G	G	5809262	3	3	269	1	0	0	0	0	1	0	0	0	11127	14	1	4	180	4	OR52N1	11	5809262	Missense_Mutation	SNP	A	TCGA-76-6280-01A-21D-1845-08		5809262	129197254	30	19279											
NAV2	89797	broad.mit.edu	37	chr11	20065785	20065785	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccaaggacgaagccttcaGccccggcaggcgcactgaag	13	14	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr11:20065785G>A	uc010rdm.1	+	14	3596	c.3235G>A	c.(3235-3237)GCC>ACC	p.A1079T	NAV2_uc001mpp.2_Missense_Mutation_p.A992T|NAV2_uc001mpr.3_Missense_Mutation_p.A1056T|NAV2_uc001mpt.2_Missense_Mutation_p.A142T|NAV2_uc009yhx.2_Missense_Mutation_p.A142T|NAV2_uc009yhy.1_Missense_Mutation_p.A55T	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1079						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GAAGCCTTCAGCCCCGGCAGG	0.567													A	20065785	A	A	20065785	3	1	269	1	0	0	0	0	1	0	0	0	10184	971	34	3	3325	3	NAV2	11	20065785	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	14256523	20065785	114940731	31	19280											
TM7SF2	7108	broad.mit.edu	37	chr11	64882420	64882420	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accatggatatcacacatgaCgggtttggcttcatgctggc	11	10	2	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr11:64882420C>T	uc001oct.2	+	7	906	c.759C>T	c.(757-759)GAC>GAT	p.D253D	TM7SF2_uc010rny.1_Silent_p.D137D|TM7SF2_uc001ocu.2_Silent_p.D253D|TM7SF2_uc001ocv.2_Silent_p.D274D|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	253					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						TCACACATGACGGGTTTGGCT	0.627													T	64882420	T	T	64882420	2	4	269	1	0	0	0	0	0	0	0	1	15971	535	19	1		1	TM7SF2	11	64882420	Silent	SNP	C	TCGA-76-6280-01A-21D-1845-08	44816635	64882420	70124096	32	19281											
KCNE3	10008	broad.mit.edu	37	chr11	74168386	74168386	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgggtgtatcccaggatgaGgctgcccacagttacagcaa	13	11	0	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr11:74168386G>A	uc001ovc.2	-	3	570	c.223C>T	c.(223-225)CTC>TTC	p.L75F	KCNE3_uc001ovd.2_Missense_Mutation_p.L75F	NM_005472	NP_005463	Q9Y6H6	KCNE3_HUMAN	potassium voltage-gated channel, Isk-related	75	Helical; (Potential).					integral to membrane	voltage-gated potassium channel activity			ovary(1)	1	Breast(11;2.86e-06)					CCCAGGATGAGGCTGCCCACA	0.512													A	74168386	A	A	74168386	3	1	269	1	0	0	0	0	1	0	0	0	8024	1000	35	3	92	3	KCNE3	11	74168386	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	9285966	74168386	60838130	33	19282											
HIP1R	9026	broad.mit.edu	37	chr12	123339938	123339938	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatcagcacagggccccccGcgggggagccagtggtgagc	17	13	1	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr12:123339938G>A	uc001udj.1	+	11	1038	c.979G>A	c.(979-981)GCG>ACG	p.A327T	HIP1R_uc001udg.1_Missense_Mutation_p.A315T|HIP1R_uc001udi.1_Missense_Mutation_p.A327T|HIP1R_uc001udk.1_5'Flank	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	327					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		AGGGCCCCCCGCGGGGGAGCC	0.677													A	123339938	A	A	123339938	3	1	269	1	0	0	0	0	1	0	0	0	7115	1087	38	1	1021	1	HIP1R	12	123339938	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08		123339938	10511957	34	19283											
TNFRSF19	55504	broad.mit.edu	37	chr13	24233260	24233260	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggacacggcgctggctgccGttatctgcagcgctctggcc	15	14	2	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr13:24233260G>A	uc001uov.1	+	6	581	c.517G>A	c.(517-519)GTT>ATT	p.V173I	TNFRSF19_uc001uot.2_Missense_Mutation_p.V173I|TNFRSF19_uc010tcu.1_Missense_Mutation_p.V41I|TNFRSF19_uc001uow.2_Missense_Mutation_p.V173I	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	173	Helical; (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		GCTGGCTGCCGTTATCTGCAG	0.577													A	24233260	A	A	24233260	3	1	269	1	0	0	0	0	1	0	0	0	16289	1145	40	1	535	1	TNFRSF19	13	24233260	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08		24233260	90936618	35	19284											
COG6	57511	broad.mit.edu	37	chr13	40268775	40268775	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tcacatattttaataggttcGaattgagcaagtaatagttg	8	4	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr13:40268775G>T	uc001uxh.2	+	12	1179	c.1079G>T	c.(1078-1080)CGA>CTA	p.R360L	COG6_uc001uxi.2_Missense_Mutation_p.R308L|COG6_uc010acb.2_Missense_Mutation_p.R360L	NM_020751	NP_065802	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6 isoform	360					protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		TAATAGGTTCGAATTGAGCAA	0.274													T	40268775	T	T	40268775	3	4	269	1	0	0	0	0	1	0	0	0	3662	1058	37	5	1125	5	COG6	13	40268775	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	16035515	40268775	74901103	36	19285											
DGKH	160851	broad.mit.edu	37	chr13	42761271	42761271	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaatgccgttgtagctgatgCcgtggccagtaaagtaagag	13	7	0	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr13:42761271C>T	uc001uyl.1	+	14	1646	c.1625C>T	c.(1624-1626)GCC>GTC	p.A542V	DGKH_uc010tfh.1_Missense_Mutation_p.A542V|DGKH_uc001uym.1_Missense_Mutation_p.A542V|DGKH_uc010tfi.1_Missense_Mutation_p.A297V|DGKH_uc010tfj.1_Missense_Mutation_p.A397V|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.A397V|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	542					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		GTAGCTGATGCCGTGGCCAGT	0.423													T	42761271	T	T	42761271	3	4	269	1	0	0	0	0	1	0	0	0	4470	739	26	3	1679	3	DGKH	13	42761271	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	2492496	42761271	72408607	37	19286											
OR4K1	79544	broad.mit.edu	37	chr14	20404282	20404282	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctatttcctgggcggtgggcGttcttcattctgtgagccac	12	11	3	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr14:20404282G>A	uc001vwj.1	+	1	457	c.457G>A	c.(457-459)GTT>ATT	p.V153I		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GGCGGTGGGCGTTCTTCATTC	0.453													A	20404282	A	A	20404282	3	1	269	1	0	0	0	0	1	0	0	0	11067	1145	40	1	459	1	OR4K1	14	20404282	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08		20404282	86945258	38	19287											
NIN	51199	broad.mit.edu	37	chr14	51239180	51239180	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggtacgtcgtccactctcatCgaaagactggaaggaggaag	13	9	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr14:51239180C>T	uc001wym.2	-	9	1011	c.820G>A	c.(820-822)GAT>AAT	p.D274N	NIN_uc001wyi.2_Missense_Mutation_p.D274N|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.D274N|NIN_uc010tqp.1_Missense_Mutation_p.D280N|NIN_uc001wyo.2_Missense_Mutation_p.D274N|NIN_uc001wyp.1_Missense_Mutation_p.D236N	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	274					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					CCACTCTCATCGAAAGACTGG	0.502			T	PDGFRB	MPD								T	51239180	T	T	51239180	3	4	269	1	0	0	0	0	1	0	0	0	10417	884	31	2	5821	2	NIN	14	51239180	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	30834898	51239180	56110360	39	19288											
SYT16	83851	broad.mit.edu	37	chr14	62567295	62567295	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taacaggcgtactatgaagcGtaaagagatgattggctgga	13	5	0	3			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr14:62567295G>A	uc001xfu.1	+	6	2005	c.1808G>A	c.(1807-1809)CGT>CAT	p.R603H	SYT16_uc010tse.1_Missense_Mutation_p.R161H	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	603	C2 2.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		ACTATGAAGCGTAAAGAGATG	0.483													A	62567295	A	A	62567295	3	1	269	1	0	0	0	0	1	0	0	0	15469	1145	40	1	1830	1	SYT16	14	62567295	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	11328115	62567295	44782245	40	19289											
DCAF5	8816	broad.mit.edu	37	chr14	69520671	69520671	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgtggccatgaacagccCtgctactatctgtggctggg	12	12	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr14:69520671C>T	uc001xkp.2	-	9	2951	c.2732G>A	c.(2731-2733)AGG>AAG	p.R911K	DCAF5_uc001xkq.2_Missense_Mutation_p.R910K	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	911						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						ATGAACAGCCCTGCTACTATC	0.473													T	69520671	T	T	69520671	3	4	269	1	0	0	0	0	1	0	0	0	4273	681	24	3	100	3	DCAF5	14	69520671	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	6953376	69520671	37828869	41	19290											
EIF2AK4	440275	broad.mit.edu	37	chr15	40280263	40280263	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caccgtcagactctggaggcTttttcgagagattctggatg	12	9	3	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr15:40280263T>C	uc001zkm.1	+	15	2533	c.2483T>C	c.(2482-2484)CTT>CCT	p.L828P	EIF2AK4_uc010bbj.1_Missense_Mutation_p.L529P	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	828	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CTCTGGAGGCTTTTTCGAGAG	0.393													C	40280263	C	C	40280263	3	2	269	1	0	0	0	0	1	0	0	0	4999	1609	56	4	2541	4	EIF2AK4	15	40280263	Missense_Mutation	SNP	T	TCGA-76-6280-01A-21D-1845-08		40280263	62251129	42	19291											
EHD4	30844	broad.mit.edu	37	chr15	42193062	42193062	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcaccatctccttcttggcGttgacacctgatatcttgcc	7	14	4	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr15:42193062G>A	uc001zot.2	-	6	1470	c.1407C>T	c.(1405-1407)AAC>AAT	p.N469N		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	469	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		CCTTCTTGGCGTTGACACCTG	0.592													A	42193062	A	A	42193062	2	1	269	1	0	0	0	0	0	0	0	1	4980	1136	40	1		1	EHD4	15	42193062	Silent	SNP	G	TCGA-76-6280-01A-21D-1845-08	1912799	42193062	60338330	43	19292											
CYP19A1	1588	broad.mit.edu	37	chr15	51504611	51504611	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaggataatgtttgtccccTttttcactgggtagccatcg	9	10	2	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr15:51504611T>C	uc001zyz.3	-	10	1420	c.1169A>G	c.(1168-1170)AAG>AGG	p.K390R	CYP19A1_uc001zza.3_Missense_Mutation_p.K390R|CYP19A1_uc001zzb.2_Missense_Mutation_p.K390R	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	390					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	GTTTGTCCCCTTTTTCACTGG	0.413													C	51504611	C	C	51504611	3	2	269	1	0	0	0	0	1	0	0	0	4148	1609	56	4	350	4	CYP19A1	15	51504611	Missense_Mutation	SNP	T	TCGA-76-6280-01A-21D-1845-08	9311549	51504611	51026781	44	19293											
CYP1A2	1544	broad.mit.edu	37	chr15	75045612	75045612	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcaggtcaaccatgacccGtgagtacatacccctcacga	9	14	2	2	rs56107638	byFrequency	TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr15:75045612G>A	uc002ayr.1	+	6	1317	c.1253_splice	c.e6+1	p.P418_splice		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,						alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	ACCATGACCCGTGAGTACATA	0.493													A	75045612	A	A	75045612	5	1	269	1	0	0	0	0	0	0	1	0	4150	1159	40	1	1272	1	CYP1A2	15	75045612	Splice_Site	SNP	G	TCGA-76-6280-01A-21D-1845-08	23541001	75045612	27485780	45	19294											
SV2B	9899	broad.mit.edu	37	chr15	91801746	91801746	+	Missense_Mutation	SNP	C	A	A													gcaccgtgtccatggtggccCtgaagttcatgccagagagc							TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr15:91801746C>A	uc002bqv.2	+	4	1271	c.880C>A	c.(880-882)CTG>ATG	p.L294M	SV2B_uc002bqt.2_Missense_Mutation_p.L294M|SV2B_uc010uqv.1_Missense_Mutation_p.L143M|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	294	Helical; (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CATGGTGGCCCTGAAGTTCAT	0.567													A	91801746	A	A	91801746	3	1	269	1	0	0	0	0	1	0	0	0	15415	680	24	5	894	5	SV2B	15	91801746	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	16756134	91801746	10729646	46	19295	26	2									
SV2B	9899	broad.mit.edu	37	chr15	91801750	91801750	+	Missense_Mutation	SNP	A	G	G													cgtgtccatggtggccctgaAgttcatgccagagagcccaa							TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr15:91801750A>G	uc002bqv.2	+	4	1275	c.884A>G	c.(883-885)AAG>AGG	p.K295R	SV2B_uc002bqt.2_Missense_Mutation_p.K295R|SV2B_uc010uqv.1_Missense_Mutation_p.K144R|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	295	Helical; (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GTGGCCCTGAAGTTCATGCCA	0.567													G	91801750	G	G	91801750	3	3	269	1	0	0	0	0	1	0	0	0	15415	72	3	4	898	4	SV2B	15	91801750	Missense_Mutation	SNP	A	TCGA-76-6280-01A-21D-1845-08	4	91801750	10729642	47	19296	26	2									
RNF40	9810	broad.mit.edu	37	chr16	30783282	30783282	+	Silent	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gagaaagagagcttcaacctCaagagggctcaggtgtgtgc	14	8	3	3			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr16:30783282C>A	uc002dzq.2	+	18	2838	c.2715C>A	c.(2713-2715)CTC>CTA	p.L905L	RNF40_uc010caa.2_Silent_p.L905L|RNF40_uc010cab.2_Silent_p.L805L|RNF40_uc010vfa.1_Silent_p.L237L|RNF40_uc002dzr.2_Silent_p.L905L|RNF40_uc010vfb.1_Silent_p.L597L|RNF40_uc010vfc.1_Silent_p.L237L	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	905	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			GCTTCAACCTCAAGAGGGCTC	0.647													A	30783282	A	A	30783282	2	1	269	1	0	0	0	0	0	0	0	1	13493	813	29	5		5	RNF40	16	30783282	Silent	SNP	C	TCGA-76-6280-01A-21D-1845-08		30783282	59571471	48	19297											
MMP15	4324	broad.mit.edu	37	chr16	58079116	58079116	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggcggacagcgcagagggCgacgtgggggatggggatgg	25	6	0	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr16:58079116C>T	uc002ena.2	+	10	2749	c.1776C>T	c.(1774-1776)GGC>GGT	p.G592G		NM_002428	NP_002419	P51511	MMP15_HUMAN	matrix metalloproteinase 15 preproprotein	592	Extracellular (Potential).				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			central_nervous_system(2)|breast(1)	3						GCGCAGAGGGCGACGTGGGGG	0.736													T	58079116	T	T	58079116	2	4	269	1	0	0	0	0	0	0	0	1	9654	755	27	1		1	MMP15	16	58079116	Silent	SNP	C	TCGA-76-6280-01A-21D-1845-08	27295834	58079116	32275637	49	19298											
ATP2C2	9914	broad.mit.edu	37	chr16	84449185	84449185	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gaccggatccctgcagacatCcgactcactgaggtgagtgg	13	12	1	3			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr16:84449185C>A	uc002fhx.2	+	7	701	c.612C>A	c.(610-612)ATC>ATA	p.I204I	ATP2C2_uc010chj.2_Silent_p.I204I|ATP2C2_uc002fhy.2_Silent_p.I221I|ATP2C2_uc002fhz.2_Silent_p.I53I	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	204	Cytoplasmic (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						CTGCAGACATCCGACTCACTG	0.507													A	84449185	A	A	84449185	2	1	269	1	0	0	0	0	0	0	0	1	1144	845	30	5		5	ATP2C2	16	84449185	Silent	SNP	C	TCGA-76-6280-01A-21D-1845-08	26370069	84449185	5905568	50	19299											
TRPV2	51393	broad.mit.edu	37	chr17	16323552	16323552	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcaagtacctcaccgactcGgaatacacaggtagaccctg	9	13	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr17:16323552G>A	uc002gpy.2	+	3	691	c.324G>A	c.(322-324)TCG>TCA	p.S108S	TRPV2_uc002gpz.2_5'UTR	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,	108	Cytoplasmic (Potential).|Required for interaction with SLC50A1 (By similarity).|ANK 1.				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TCACCGACTCGGAATACACAG	0.582													A	16323552	A	A	16323552	2	1	269	1	0	0	0	0	0	0	0	1	16593	1103	39	2		2	TRPV2	17	16323552	Silent	SNP	G	TCGA-76-6280-01A-21D-1845-08		16323552	64871658	51	19300											
MAP2K3	5606	broad.mit.edu	37	chr17	21201792	21201792	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacccgcacccaaccccacGtgagtctgcctcagtttctc	6	20	3	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr17:21201792G>A	uc002gys.2	+	2	381	c.116_splice	c.e2+1	p.T39_splice	MAP2K3_uc002gyt.2_Splice_Site_p.T10_splice|MAP2K3_uc002gyu.2_Splice_Site_p.T10_splice	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3						activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CCAACCCCACGTGAGTCTGCC	0.577													A	21201792	A	A	21201792	5	1	269	1	0	0	0	0	0	0	1	0	9238	1159	40	1	123	1	MAP2K3	17	21201792	Splice_Site	SNP	G	TCGA-76-6280-01A-21D-1845-08	4878240	21201792	59993418	52	19301											
TMEM132E	124842	broad.mit.edu	37	chr17	32953325	32953325	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccgagcccttcgtggtgttcCagaccaaggagctgccggtc	13	14	0	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr17:32953325C>A	uc002hif.2	+	2	575	c.247C>A	c.(247-249)CAG>AAG	p.Q83K		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	83	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CGTGGTGTTCCAGACCAAGGA	0.697													A	32953325	A	A	32953325	3	1	269	1	0	0	0	0	1	0	0	0	16045	595	21	5	253	5	TMEM132E	17	32953325	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	11751533	32953325	48241885	53	19302											
MAPT	4137	broad.mit.edu	37	chr17	44067273	44067273	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	cgttcctctgctaaaaccttGaaaaataggccttgccttag	7	11	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr17:44067273G>A	uc002ijr.3	+	8	1532	c.1212G>A	c.(1210-1212)TTG>TTA	p.L404L	MAPT_uc010dau.2_Silent_p.L404L|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	404					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CTAAAACCTTGAAAAATAGGC	0.463													A	44067273	A	A	44067273	2	1	269	1	0	0	0	0	0	0	0	1	9297	1281	45	3		3	MAPT	17	44067273	Silent	SNP	G	TCGA-76-6280-01A-21D-1845-08	11113948	44067273	37127937	54	19303											
KIF2B	84643	broad.mit.edu	37	chr17	51901778	51901778	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatacaaccaaggccagcCggaaaaggcagctggaaggg	14	10	0	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr17:51901778C>T	uc002iua.2	+	1	1540	c.1384C>T	c.(1384-1386)CGG>TGG	p.R462W	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	462	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CAAGGCCAGCCGGAAAAGGCA	0.488													T	51901778	T	T	51901778	3	4	269	1	0	0	0	0	1	0	0	0	8298	643	23	2	1386	2	KIF2B	17	51901778	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	7834505	51901778	29293432	55	19304											
CLTC	1213	broad.mit.edu	37	chr17	57738898	57738898	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acttcagtactttggtatccTtttggaccagggacagctca	9	10	2	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr17:57738898T>C	uc002ixq.1	+	8	1705	c.1262T>C	c.(1261-1263)CTT>CCT	p.L421P	CLTC_uc002ixp.2_Missense_Mutation_p.L421P|CLTC_uc002ixr.1_Missense_Mutation_p.L425P	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	421	Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TTTGGTATCCTTTTGGACCAG	0.458			T	ALK|TFE3	ALCL|renal 								C	57738898	C	C	57738898	3	2	269	1	0	0	0	0	1	0	0	0	3566	1609	56	4	1292	4	CLTC	17	57738898	Missense_Mutation	SNP	T	TCGA-76-6280-01A-21D-1845-08	5837120	57738898	23456312	56	19305											
AANAT	15	broad.mit.edu	37	chr17	74465804	74465804	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccacctgcatgtgctggccGtgcaccgcgccttccggcag	12	18	0	0	rs72466447		TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr17:74465804G>A	uc002jro.2	+	4	610	c.376G>A	c.(376-378)GTG>ATG	p.V126M	AANAT_uc010wte.1_RNA	NM_001088	NP_001079	Q16613	SNAT_HUMAN	arylalkylamine N-acetyltransferase	126	Acetyl-CoA binding (By similarity).|N-acetyltransferase.				circadian rhythm|melatonin biosynthetic process	cytosol	aralkylamine N-acetyltransferase activity				0						TGTGCTGGCCGTGCACCGCGC	0.692													A	74465804	A	A	74465804	3	1	269	1	0	0	0	0	1	0	0	0	18	1145	40	1	525	1	AANAT	17	74465804	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	16726906	74465804	6729406	57	19306											
RAC3	5881	broad.mit.edu	37	chr17	79991354	79991354	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caccactgcccccacacgccCatcctcctggtgggcaccaa	7	21	0	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr17:79991354C>T	uc002kdf.2	+	5	433	c.327C>T	c.(325-327)CCC>CCT	p.P109P		NM_005052	NP_005043	P60763	RAC3_HUMAN	ras-related C3 botulinum toxin substrate 3 (rho	109					actin cytoskeleton organization|cell projection assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endomembrane system|filamentous actin|growth cone|lamellipodium|neuronal cell body|plasma membrane	GTP binding|GTPase activity|protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CCCACACGCCCATCCTCCTGG	0.672													T	79991354	T	T	79991354	2	4	269	1	0	0	0	0	0	0	0	1	12976	581	21	3		3	RAC3	17	79991354	Silent	SNP	C	TCGA-76-6280-01A-21D-1845-08	5525550	79991354	1203856	58	19307											
ADNP2	22850	broad.mit.edu	37	chr18	77893797	77893797	+	Nonsense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aacttttcaaacactttgtaCtacagcatgaagaagcatgt	6	8	1	2			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr18:77893797C>G	uc002lnw.2	+	4	956	c.501C>G	c.(499-501)TAC>TAG	p.Y167*		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	167					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		ACACTTTGTACTACAGCATGA	0.373													G	77893797	G	G	77893797	4	3	269	1	0	0	0	0	0	1	0	0	324	576	20	5	511	5	ADNP2	18	77893797	Nonsense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08		77893797	183451	59	19308											
TJP3	27134	broad.mit.edu	37	chr19	3731941	3731941	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccccccttacagagtttggcGtcaagctgggcagtcagatc	11	13	2	2	rs146857520		TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr19:3731941G>A	uc010xhv.1	+	5	679	c.679G>A	c.(679-681)GTC>ATC	p.V227I	TJP3_uc010xhs.1_Missense_Mutation_p.V208I|TJP3_uc010xht.1_Missense_Mutation_p.V172I|TJP3_uc010xhu.1_Missense_Mutation_p.V217I|TJP3_uc010xhw.1_Missense_Mutation_p.V227I	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	208	PDZ 2.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGTTTGGCGTCAAGCTGGG	0.592													A	3731941	A	A	3731941	3	1	269	1	0	0	0	0	1	0	0	0	15928	1145	40	1	697	1	TJP3	19	3731941	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08		3731941	55397042	60	19309											
ZNF700	90592	broad.mit.edu	37	chr19	12059987	12059988	+	Frame_Shift_Del	DEL	CT	-	-													atttcaaacacatgaaaaaaCtcacactggagagaaacgct							TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr19:12059987_12059988delCT	uc002msu.2	+	4	1274_1275	c.1148_1149delCT	c.(1147-1149)ACTfs	p.T383fs	ZNF700_uc010xme.1_Frame_Shift_Del_p.T401fs|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	383	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATGAAAAAACTCACACTGGAG	0.371													-	12059988	-	-	12059987	7	5	269	1	0	1	0	1	0	0	0	0	18101	565	20	0	1162	0	ZNF700	19	12059987	Frame_Shift_Del	DEL	CT	TCGA-76-6280-01A-21D-1845-08	8328046	12059987	47068996	61	19310											
C19orf62	29086	broad.mit.edu	37	chr19	17384818	17384818	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgcactggtggtggtgaaCgatgacacggcctgggtgag	17	7	0	3			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr19:17384818C>T	uc002nfu.2	+	4	568	c.450C>T	c.(448-450)AAC>AAT	p.N150N	C19orf62_uc010xpl.1_Intron|C19orf62_uc002nfv.2_Silent_p.N150N|C19orf62_uc010ean.2_RNA|C19orf62_uc002nfw.2_Silent_p.N150N	NM_014173	NP_054892	Q9NWV8	BABA1_HUMAN	mediator of Rap80 interactions and targeting 40	150	VWFA-like.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|protein K63-linked deubiquitination|response to ionizing radiation	BRCA1-A complex|BRISC complex|cytoplasm	protein binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2						TGGTGGTGAACGATGACACGG	0.607													T	17384818	T	T	17384818	2	4	269	1	0	0	0	0	0	0	0	1	1944	535	19	1		1	C19orf62	19	17384818	Silent	SNP	C	TCGA-76-6280-01A-21D-1845-08	5324831	17384818	41744165	62	19311											
CILP2	148113	broad.mit.edu	37	chr19	19656132	19656132	+	Silent	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gcctcctggactggcgatctCctggcctggtggcccaaccc	12	17	1	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr19:19656132C>G	uc002nmv.3	+	8	2863	c.2778C>G	c.(2776-2778)CTC>CTG	p.L926L	CILP2_uc002nmw.3_Silent_p.L932L	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	926						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CTGGCGATCTCCTGGCCTGGT	0.647													G	19656132	G	G	19656132	2	3	269	1	0	0	0	0	0	0	0	1	3430	842	30	5		5	CILP2	19	19656132	Silent	SNP	C	TCGA-76-6280-01A-21D-1845-08	2271314	19656132	39472851	63	19312											
CD22	933	broad.mit.edu	37	chr19	35837131	35837131	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttattcagcattgcacaagcGccaagtggtaaggagggtct	12	8	2	0			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr19:35837131G>A	uc010edt.2	+	13	2482	c.2405G>A	c.(2404-2406)CGC>CAC	p.R802H	CD22_uc010xst.1_Missense_Mutation_p.R630H|CD22_uc010edu.2_Missense_Mutation_p.R714H|CD22_uc010edv.2_3'UTR|CD22_uc002nzb.3_Missense_Mutation_p.R625H|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	802	Cytoplasmic (Potential).				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TTGCACAAGCGCCAAGTGGTA	0.597													A	35837131	A	A	35837131	3	1	269	1	0	0	0	0	1	0	0	0	2985	1087	38	1	2451	1	CD22	19	35837131	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	16180999	35837131	23291852	64	19313											
ADCK4	79934	broad.mit.edu	37	chr19	41209757	41209757	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gccgagctcctcttcaagaaCtctctgcggggagtggtcac	12	13	4	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr19:41209757C>G	uc002oor.2	-	8	882	c.580G>C	c.(580-582)GTT>CTT	p.V194L	ADCK4_uc002oop.1_5'Flank|ADCK4_uc002ooq.1_Missense_Mutation_p.V153L	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	194	Protein kinase.					integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			tcttcaagaactctcTGCGGG	0.259													G	41209757	G	G	41209757	3	3	269	1	0	0	0	0	1	0	0	0	290	565	20	5	1086	5	ADCK4	19	41209757	Missense_Mutation	SNP	C	TCGA-76-6280-01A-21D-1845-08	5372626	41209757	17919226	65	19314											
LILRA3	11026	broad.mit.edu	37	chr19	54800078	54800078	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttggagtcggacttgttttGtggtgggctgagggtctcag	17	6	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr19:54800078G>A	uc002qfd.2	-	7	1353	c.1288C>T	c.(1288-1290)CAA>TAA	p.Q430*	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Nonsense_Mutation_p.Q366*	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	430					defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACTTGTTTTGTGGTGGGCTG	0.507													A	54800078	A	A	54800078	4	1	269	1	0	0	0	0	0	1	0	0	8786	1386	48	3	35	3	LILRA3	19	54800078	Nonsense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	13590321	54800078	4328905	66	19315											
TPX2	22974	broad.mit.edu	37	chr20	30347914	30347914	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaagaatggaactggagggcTttttcagggcaaaactcctt	12	7	1	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr20:30347914T>C	uc002wwp.1	+	4	859	c.161T>C	c.(160-162)CTT>CCT	p.L54P	TPX2_uc010gdv.1_Missense_Mutation_p.L54P	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	54					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			ACTGGAGGGCTTTTTCAGGGC	0.413													C	30347914	C	C	30347914	3	2	269	1	0	0	0	0	1	0	0	0	16429	1609	56	4	167	4	TPX2	20	30347914	Missense_Mutation	SNP	T	TCGA-76-6280-01A-21D-1845-08		30347914	32677606	67	19316											
NFATC2	4773	broad.mit.edu	37	chr20	50139989	50139989	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctggggtgaggctccgggcGgcagggcaaccaaggcctcg	19	12	0	1			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr20:50139989G>A	uc002xwd.2	-	2	1011	c.791C>T	c.(790-792)CCG>CTG	p.P264L	NFATC2_uc002xwc.2_Missense_Mutation_p.P264L|NFATC2_uc010zyv.1_Missense_Mutation_p.P45L|NFATC2_uc010zyw.1_Missense_Mutation_p.P45L|NFATC2_uc010zyx.1_Missense_Mutation_p.P244L|NFATC2_uc010zyy.1_Missense_Mutation_p.P45L|NFATC2_uc010zyz.1_Missense_Mutation_p.P45L|NFATC2_uc002xwe.2_Missense_Mutation_p.P244L	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	264	3 X approximate SP repeats.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GGCTCCGGGCGGCAGGGCAAC	0.751													A	50139989	A	A	50139989	3	1	269	1	0	0	0	0	1	0	0	0	10362	1116	39	2	2070	2	NFATC2	20	50139989	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	19792075	50139989	12885531	68	19317											
RPS21	6227	broad.mit.edu	37	chr20	60963374	60963374	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tttttcttaagggtgagtcaGatgattccattctccgattg	9	7	3	3			TCGA-76-6280-01A-21D-1845-08	TCGA-76-6280-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	9096e339-7730-4d7a-acab-a6c4d26c52c3	cafac2eb-4554-4aac-b94d-ba88ded2d361	g.chr20:60963374G>C	uc002ycr.2	+	5	286	c.196G>C	c.(196-198)GAT>CAT	p.D66H	RPS21_uc002ycs.2_Missense_Mutation_p.D66H|RPS21_uc002yct.2_3'UTR|RPS21_uc002ycu.2_Missense_Mutation_p.D66H	NM_001024	NP_001015	P63220	RS21_HUMAN	ribosomal protein S21	66					endocrine pancreas development|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein N-terminus binding|structural constituent of ribosome				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			GGGTGAGTCAGATGATTCCAT	0.507													C	60963374	C	C	60963374	3	2	269	1	0	0	0	0	1	0	0	0	13633	942	33	5	210	5	RPS21	20	60963374	Missense_Mutation	SNP	G	TCGA-76-6280-01A-21D-1845-08	10823385	60963374	2062146	69	19318											
AADACL3	126767	broad.mit.edu	37	chr1	12785683	12785683	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaagctgcttacttggaagTaagtgttgtcctggatgtga	13	5	0	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr1:12785683T>C	uc009vnn.1	+	4	1006	c.773T>C	c.(772-774)GTA>GCA	p.V258A	AADACL3_uc001aug.1_Missense_Mutation_p.V188A	NM_001103170	NP_001096640	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3 isoform 1	258							hydrolase activity				0	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TACTTGGAAGTAAGTGTTGTC	0.502													C	12785683	C	C	12785683	3	2	270	1	0	0	0	0	1	0	0	0	12	1638	57	4	791	4	AADACL3	1	12785683	Missense_Mutation	SNP	T	TCGA-76-6282-01A-11D-1696-08		12785683	236464938	1	19319											
C1orf129	80133	broad.mit.edu	37	chr1	170964598	170964598	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggtggcccagtatttcccCcagctcttgacgactcttat	9	14	2	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr1:170964598C>T	uc001ghg.2	+	13	1393	c.1263C>T	c.(1261-1263)CCC>CCT	p.P421P	C1orf129_uc009wvy.2_Silent_p.P228P|C1orf129_uc010plz.1_Silent_p.P421P	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	421							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGTATTTCCCCCAGCTCTTGA	0.473													T	170964598	T	T	170964598	2	4	270	1	0	0	0	0	0	0	0	1	1996	610	22	3		3	C1orf129	1	170964598	Silent	SNP	C	TCGA-76-6282-01A-11D-1696-08	158178915	170964598	78286023	2	19320											
MFSD9	84804	broad.mit.edu	37	chr2	103335367	103335367	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgggccgcaccccaaagcGctcctccagggccaggacaa	11	17	0	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr2:103335367G>A	uc002tcb.2	-	6	1005	c.937C>T	c.(937-939)CGC>TGC	p.R313C	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	313					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						ACCCCAAAGCGCTCCTCCAGG	0.587													A	103335367	A	A	103335367	3	1	270	1	0	0	0	0	1	0	0	0	9539	1087	38	1	491	1	MFSD9	2	103335367	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08		103335367	139864006	3	19321											
SLC5A7	60482	broad.mit.edu	37	chr2	108626710	108626710	+	Frame_Shift_Del	DEL	G	-	-													ttcggacaaagaaatcgtttGggttatgcgaatcacagtgt							TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr2:108626710delG	uc002tdv.2	+	9	1412	c.1136delG	c.(1135-1137)TGGfs	p.W379fs	SLC5A7_uc010ywm.1_Frame_Shift_Del_p.W132fs|SLC5A7_uc010fjj.2_Frame_Shift_Del_p.W379fs|SLC5A7_uc010ywn.1_Frame_Shift_Del_p.W266fs	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	379	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GAAATCGTTTGGGTTATGCGA	0.443													-	108626710	-	-	108626710	7	5	270	1	0	1	0	1	0	0	0	0	14670	1357	47	0	1166	0	SLC5A7	2	108626710	Frame_Shift_Del	DEL	G	TCGA-76-6282-01A-11D-1696-08	5291343	108626710	134572663	4	19322											
WNT10A	80326	broad.mit.edu	37	chr2	219746954	219746954	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caatgccaacacagtgtgccTaacattgccaggcctgagcc	9	14	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr2:219746954T>C	uc002vjd.1	+	2	648	c.185T>C	c.(184-186)CTA>CCA	p.L62P		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	62					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACAGTGTGCCTAACATTGCCA	0.612													C	219746954	C	C	219746954	3	2	270	1	0	0	0	0	1	0	0	0	17379	1522	53	4	191	4	WNT10A	2	219746954	Missense_Mutation	SNP	T	TCGA-76-6282-01A-11D-1696-08	111120244	219746954	23452419	5	19323											
AGAP1	116987	broad.mit.edu	37	chr2	236659063	236659063	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaggaagctctccaacgacCtgaaacggtgcacgtactac	10	13	1	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr2:236659063C>T	uc002vvs.2	+	6	1199	c.604C>T	c.(604-606)CTG>TTG	p.L202L	AGAP1_uc002vvt.2_Silent_p.L202L	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	202	Small GTPase-like.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						CTCCAACGACCTGAAACGGTG	0.527													T	236659063	T	T	236659063	2	4	270	1	0	0	0	0	0	0	0	1	366	680	24	3		3	AGAP1	2	236659063	Silent	SNP	C	TCGA-76-6282-01A-11D-1696-08	16912109	236659063	6540310	6	19324											
FGD5	152273	broad.mit.edu	37	chr3	14862054	14862054	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctgggaaggtggccggctaTgtcccagaaaccgtccctga	13	12	1	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr3:14862054T>C	uc003bzc.2	+	1	1586	c.1476T>C	c.(1474-1476)TAT>TAC	p.Y492Y	FGD5_uc011avk.1_Silent_p.Y492Y	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	492					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						TGGCCGGCTATGTCCCAGAAA	0.612													C	14862054	C	C	14862054	2	2	270	1	0	0	0	0	0	0	0	1	5836	1471	51	4		4	FGD5	3	14862054	Silent	SNP	T	TCGA-76-6282-01A-11D-1696-08		14862054	183160376	7	19325											
EFHB	151651	broad.mit.edu	37	chr3	19974766	19974766	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	aaaaaacttcccagagtataTgggtctgatgcgatctggag	11	7	2	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr3:19974766T>A	uc003cbl.3	-	1	941	c.745A>T	c.(745-747)ATA>TTA	p.I249L	EFHB_uc003cbm.2_Missense_Mutation_p.I119L	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	249					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						CCAGAGTATATGGGTCTGATG	0.443													A	19974766	A	A	19974766	3	1	270	1	0	0	0	0	1	0	0	0	4945	1464	51	5	1808	5	EFHB	3	19974766	Missense_Mutation	SNP	T	TCGA-76-6282-01A-11D-1696-08	5112712	19974766	178047664	8	19326											
BOC	91653	broad.mit.edu	37	chr3	112997000	112997000	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cattccagccaaccagcaccGcctgaccctcaccagacttg	6	19	1	2	rs149038528		TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr3:112997000G>A	uc003dzx.2	+	10	2219	c.1598G>A	c.(1597-1599)CGC>CAC	p.R533H	BOC_uc003dzy.2_Missense_Mutation_p.R533H|BOC_uc003dzz.2_Missense_Mutation_p.R534H|BOC_uc003eab.2_Missense_Mutation_p.R234H|BOC_uc003eac.2_5'Flank	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	533	Fibronectin type-III 1.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			AACCAGCACCGCCTGACCCTC	0.567													A	112997000	A	A	112997000	3	1	270	1	0	0	0	0	1	0	0	0	1481	1087	38	1	1628	1	BOC	3	112997000	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08	93022234	112997000	85025430	9	19327											
KDR	3791	broad.mit.edu	37	chr4	55956221	55956221	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccgataagaggatatttcGtgccgccaggtccctgtgga	12	11	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr4:55956221G>A	uc003has.2	-	23	3396	c.3094C>T	c.(3094-3096)CGA>TGA	p.R1032*	KDR_uc003hat.1_Nonsense_Mutation_p.R1032*	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1032	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGGATATTTCGTGCCGCCAGG	0.448			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			A	55956221	A	A	55956221	4	1	270	1	0	0	0	0	0	1	0	0	8139	1153	40	1	1008	1	KDR	4	55956221	Nonsense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08		55956221	135198055	10	19328											
PROL1	58503	broad.mit.edu	37	chr4	71275177	71275177	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ccactctacaggccaagatgGgttccaccaagtcccccacc	7	18	1	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr4:71275177G>T	uc003hfi.2	+	3	306	c.132G>T	c.(130-132)TGG>TGT	p.W44C		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	44	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				GGCCAAGATGGGTTCCACCAA	0.502													T	71275177	T	T	71275177	3	4	270	1	0	0	0	0	1	0	0	0	12554	1241	43	5	138	5	PROL1	4	71275177	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08	15318956	71275177	119879099	11	19329											
HSD17B13	345275	broad.mit.edu	37	chr4	88239495	88239495	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctcacctgatttagagagcGatagatctcttctctgttgc	8	10	3	3			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr4:88239495G>A	uc003hqo.2	-	2	367	c.304C>T	c.(304-306)CGC>TGC	p.R102C	HSD17B13_uc010ikk.2_Intron	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	102						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TTTAGAGAGCGATAGATCTCT	0.468													A	88239495	A	A	88239495	3	1	270	1	0	0	0	0	1	0	0	0	7382	1058	37	2	622	2	HSD17B13	4	88239495	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08	16964318	88239495	102914781	12	19330											
NAIP	4671	broad.mit.edu	37	chr5	70307168	70307168	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cccaatttcctaaacatccaCcacaggaaaaacactgtacc	3	15	0	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr5:70307168C>A	uc003kar.1	-	5	1320	c.602G>T	c.(601-603)GGT>GTT	p.G201V	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.G201V|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	201	BIR 2.				anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		TAAACATCCACCACAGGAAAA	0.393													A	70307168	A	A	70307168	3	1	270	1	0	0	0	0	1	0	0	0	10147	507	18	5	3661	5	NAIP	5	70307168	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08		70307168	110608092	13	19331											
PTCD2	79810	broad.mit.edu	37	chr5	71616252	71616252	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	ctgcatttcggccctcgaatCgagttctcctgcaggcgctg	11	14	1	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr5:71616252C>G	uc003kcb.2	+	1	53	c.43C>G	c.(43-45)CGA>GGA	p.R15G	MRPS27_uc003kca.3_5'Flank|MRPS27_uc003kbz.3_5'Flank|MRPS27_uc011cse.1_5'Flank|MRPS27_uc010iza.2_5'Flank|PTCD2_uc011csf.1_Translation_Start_Site|PTCD2_uc003kcc.2_Translation_Start_Site|PTCD2_uc011csg.1_Translation_Start_Site|PTCD2_uc011csh.1_Missense_Mutation_p.R15G|PTCD2_uc003kcd.2_RNA	NM_024754	NP_079030	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	15											0		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		GCCCTCGAATCGAGTTCTCCT	0.627													G	71616252	G	G	71616252	3	3	270	1	0	0	0	0	1	0	0	0	12728	876	31	5	45	5	PTCD2	5	71616252	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	1309084	71616252	109299008	14	19332											
DDX41	51428	broad.mit.edu	37	chr5	176942773	176942773	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggtatttcttccgcacgcGctcatgtcgctcttcagaca	9	13	4	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr5:176942773G>A	uc003mho.2	-	6	505	c.484C>T	c.(484-486)CGC>TGC	p.R162C	DDX41_uc003mhm.2_5'UTR|DDX41_uc003mhn.2_Missense_Mutation_p.R31C|DDX41_uc003mhp.2_Missense_Mutation_p.R31C|DDX41_uc003mhq.1_5'UTR	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	162					apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			ttccgcacgcgctcatgtcgc	0.129													A	176942773	A	A	176942773	3	1	270	1	0	0	0	0	1	0	0	0	4361	1087	38	1	1432	1	DDX41	5	176942773	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08	105326521	176942773	3972487	15	19333											
MYLIP	29116	broad.mit.edu	37	chr6	16130808	16130808	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gtgtgcaggcgactgggaatCatagaagttgactattttgg	14	5	1	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr6:16130808C>G	uc003nbq.2	+	2	345	c.108C>G	c.(106-108)ATC>ATG	p.I36M	MYLIP_uc003nbr.2_Intron	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	36	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GACTGGGAATCATAGAAGTTG	0.468													G	16130808	G	G	16130808	3	3	270	1	0	0	0	0	1	0	0	0	10055	816	29	5	114	5	MYLIP	6	16130808	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08		16130808	154984259	16	19334											
MYLIP	29116	broad.mit.edu	37	chr6	16130886	16130886	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ctaaacctgagaaaccggatCtcccagcagatggatgggct	11	11	1	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr6:16130886C>T	uc003nbq.2	+	2	423	c.186C>T	c.(184-186)ATC>ATT	p.I62I	MYLIP_uc003nbr.2_Intron	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	62	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GAAACCGGATCTCCCAGCAGA	0.473													T	16130886	T	T	16130886	2	4	270	1	0	0	0	0	0	0	0	1	10055	903	32	3		3	MYLIP	6	16130886	Silent	SNP	C	TCGA-76-6282-01A-11D-1696-08	78	16130886	154984181	17	19335											
TNXB	7148	broad.mit.edu	37	chr6	32012858	32012858	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaggaggaacctgtagggggTgctgggctccaggcctgaga	19	8	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr6:32012858T>C	uc003nzl.2	-	32	11048	c.10846A>G	c.(10846-10848)ACC>GCC	p.T3616A	TNXB_uc003nzg.1_Missense_Mutation_p.T47A|TNXB_uc003nzh.1_Missense_Mutation_p.T85A	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3663	Fibronectin type-III 28.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTGTAGGGGGTGCTGGGCTCC	0.642													C	32012858	C	C	32012858	3	2	270	1	0	0	0	0	1	0	0	0	16343	1696	59	4	3919	4	TNXB	6	32012858	Missense_Mutation	SNP	T	TCGA-76-6282-01A-11D-1696-08	15881972	32012858	139102209	18	19336											
MLN	4295	broad.mit.edu	37	chr6	33768891	33768891	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtctgggaggccagcatgGcagctacatgcaccaccagc	12	15	1	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr6:33768891G>A	uc003off.1	-	2	121	c.50C>T	c.(49-51)GCC>GTC	p.A17V	MLN_uc003ofg.1_Missense_Mutation_p.A17V|MLN_uc011drn.1_Missense_Mutation_p.A17V	NM_002418	NP_002409	P12872	MOTI_HUMAN	motilin isoform 1 preproprotein	17					cell-cell signaling|G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	hormone activity				0						GGCCAGCATGGCAGCTACATG	0.537													A	33768891	A	A	33768891	3	1	270	1	0	0	0	0	1	0	0	0	9631	1203	42	3	313	3	MLN	6	33768891	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08	1756033	33768891	137346176	19	19337											
SRPK1	6732	broad.mit.edu	37	chr6	35838178	35838178	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	gcccgactctttctccatttCctcaatttcctgcattcgct	4	16	3	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr6:35838178C>G	uc003olj.2	-	10	994	c.871G>C	c.(871-873)GAA>CAA	p.E291Q	SRPK1_uc011dtg.1_Missense_Mutation_p.E275Q|SRPK1_uc003olh.2_Missense_Mutation_p.E184Q|SRPK1_uc003oli.2_Missense_Mutation_p.E184Q	NM_003137	NP_003128	Q96SB4	SRPK1_HUMAN	SFRS protein kinase 1	291	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						TTCTCCATTTCCTCAATTTCC	0.383													G	35838178	G	G	35838178	3	3	270	1	0	0	0	0	1	0	0	0	15158	864	30	5	1124	5	SRPK1	6	35838178	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	2069287	35838178	135276889	20	19338											
VPS41	27072	broad.mit.edu	37	chr7	38798055	38798055	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttattatacagatctccaggCcattctcggatcaatgtggc	8	10	3	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr7:38798055C>A	uc003tgy.2	-	18	1475	c.1449G>T	c.(1447-1449)TGG>TGT	p.W483C	VPS41_uc003tgz.2_Missense_Mutation_p.W458C|VPS41_uc010kxn.2_Missense_Mutation_p.W394C	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	483					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						GATCTCCAGGCCATTCTCGGA	0.328													A	38798055	A	A	38798055	3	1	270	1	0	0	0	0	1	0	0	0	17207	740	26	5	1163	5	VPS41	7	38798055	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08		38798055	120340608	21	19339											
EGFR	1956	broad.mit.edu	37	chr7	55231506	55231506	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcaggccatgaacatcacctGcacaggacgggtaagagccc	11	13	2	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr7:55231506G>C	uc003tqk.2	+	14	1958	c.1712G>C	c.(1711-1713)TGC>TCC	p.C571S	EGFR_uc003tqi.2_Missense_Mutation_p.C571S|EGFR_uc003tqj.2_Missense_Mutation_p.C571S|EGFR_uc010kzg.1_Missense_Mutation_p.C526S|EGFR_uc011kco.1_Missense_Mutation_p.C518S|EGFR_uc011kcp.1_Intron|EGFR_uc011kcq.1_Intron|EGFR_uc003tqn.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	571	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AACATCACCTGCACAGGACGG	0.557		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			C	55231506	C	C	55231506	3	2	270	1	0	0	0	0	1	0	0	0	4967	1319	46	5	1777	5	EGFR	7	55231506	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08	16433451	55231506	103907157	22	19340											
ASNS	440	broad.mit.edu	37	chr7	97483890	97483890	+	Splice_Site	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	caatagcctctaaaaatattAcccatgggcagcagtagttc	7	10	1	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr7:97483890A>G	uc003uot.3	-	10	1744	c.1238_splice	c.e10+1	p.G413_splice	ASNS_uc011kin.1_Splice_Site_p.G330_splice|ASNS_uc003uou.3_Splice_Site_p.G413_splice|ASNS_uc003uov.3_Splice_Site_p.G413_splice|ASNS_uc011kio.1_Splice_Site_p.G392_splice|ASNS_uc003uow.3_Splice_Site_p.G392_splice|ASNS_uc003uox.3_Splice_Site_p.G330_splice	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase						cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TAAAAATATTACCCATGGGCA	0.343													G	97483890	G	G	97483890	5	3	270	1	0	0	0	0	0	0	1	0	1048	405	14	4	461	4	ASNS	7	97483890	Splice_Site	SNP	A	TCGA-76-6282-01A-11D-1696-08	42252384	97483890	61654773	23	19341											
OR2A25	392138	broad.mit.edu	37	chr7	143771890	143771890	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgcctgtgcggatacccacaTtaatgaggtaatggttttgg	12	7	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr7:143771890T>C	uc011ktx.1	+	1	578	c.578T>C	c.(577-579)ATT>ACT	p.I193T		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GATACCCACATTAATGAGGTA	0.433													C	143771890	C	C	143771890	3	2	270	1	0	0	0	0	1	0	0	0	10978	1493	52	4	580	4	OR2A25	7	143771890	Missense_Mutation	SNP	T	TCGA-76-6282-01A-11D-1696-08	46288000	143771890	15366773	24	19342											
IKBKB	3551	broad.mit.edu	37	chr8	42163910	42163910	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccaaggagctggatcaggGcagtctttgcacatcattcg	12	10	3	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr8:42163910G>A	uc003xow.1	+	7	704	c.527G>A	c.(526-528)GGC>GAC	p.G176D	IKBKB_uc003xov.2_Missense_Mutation_p.G176D|IKBKB_uc010lxh.1_Missense_Mutation_p.G71D|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Intron|IKBKB_uc003xox.1_5'UTR|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.G174D|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.G117D	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	176	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	CTGGATCAGGGCAGTCTTTGC	0.478													A	42163910	A	A	42163910	3	1	270	1	0	0	0	0	1	0	0	0	7611	1203	42	3	549	3	IKBKB	8	42163910	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08		42163910	104200112	25	19343											
DCAF4L2	138009	broad.mit.edu	37	chr8	88886131	88886131	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	cgtagcatggaaggtgcattGagtcccactctgactgtctt	11	10	2	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr8:88886131G>C	uc003ydz.2	-	1	166	c.69C>G	c.(67-69)CTC>CTG	p.L23L		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	23										ovary(1)	1						AAGGTGCATTGAGTCCCACTC	0.532													C	88886131	C	C	88886131	2	2	270	1	0	0	0	0	0	0	0	1	4272	1277	45	5		5	DCAF4L2	8	88886131	Silent	SNP	G	TCGA-76-6282-01A-11D-1696-08	46722221	88886131	57477891	26	19344											
RIMS2	9699	broad.mit.edu	37	chr8	105001597	105001597	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacattataatacaattagcCgaatggacagacatcgtgtc	8	8	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr8:105001597C>T	uc003yls.2	+	15	2567	c.2326C>T	c.(2326-2328)CGA>TGA	p.R776*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.R998*|RIMS2_uc003ylw.2_Nonsense_Mutation_p.R790*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.R790*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.R837*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1060					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TACAATTAGCCGAATGGACAG	0.368										HNSCC(12;0.0054)			T	105001597	T	T	105001597	4	4	270	1	0	0	0	0	0	1	0	0	13368	644	23	2	3184	2	RIMS2	8	105001597	Nonsense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	16115466	105001597	41362425	27	19345											
COLEC10	10584	broad.mit.edu	37	chr8	120101985	120101985	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaagtgggacgcatggggcCgaaaggtaactaaaatgatg	14	6	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr8:120101985C>T	uc003yoo.2	+	2	312	c.215C>T	c.(214-216)CCG>CTG	p.P72L		NM_006438	NP_006429	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 precursor	72	Collagen-like.					collagen|cytoplasm	mannose binding			ovary(2)|skin(1)	3	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			CGCATGGGGCCGAAAGGTAAC	0.413													T	120101985	T	T	120101985	3	4	270	1	0	0	0	0	1	0	0	0	3710	652	23	2	221	2	COLEC10	8	120101985	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	15100388	120101985	26262037	28	19346											
FAM75A3	727830	broad.mit.edu	37	chr9	40702866	40702866	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ccccatcaccaggcccaatgAccacctcagtctcctcccta	4	21	3	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr9:40702866A>T	uc010mmj.2	+	4	552	c.523A>T	c.(523-525)ACC>TCC	p.T175S		NM_001083124	NP_001076593	Q5VYP0	F75A3_HUMAN	hypothetical protein LOC727830	175	Pro-rich.					integral to membrane				ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		AGGCCCAATGACCACCTCAGT	0.592													T	40702866	T	T	40702866	3	4	270	1	0	0	0	0	1	0	0	0	5621	275	10	5	537	5	FAM75A3	9	40702866	Missense_Mutation	SNP	A	TCGA-76-6282-01A-11D-1696-08		40702866	100510565	29	19347											
OR52B4	143496	broad.mit.edu	37	chr11	4389252	4389252	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgatccagggagatgtcccCagcacggaaccagaagatag	12	11	0	3			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr11:4389252C>T	uc010qye.1	-	1	274	c.274G>A	c.(274-276)GGG>AGG	p.G92R		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGATGTCCCCAGCACGGAAC	0.527													T	4389252	T	T	4389252	3	4	270	1	0	0	0	0	1	0	0	0	11112	594	21	3	674	3	OR52B4	11	4389252	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08		4389252	130617264	30	19348											
ANO5	203859	broad.mit.edu	37	chr11	22296134	22296134	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcctttattgttgcatttaCgtcagacatcattccccgtc	7	12	2	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr11:22296134C>T	uc001mqi.2	+	20	2572	c.2255C>T	c.(2254-2256)ACG>ATG	p.T752M	ANO5_uc001mqj.2_Missense_Mutation_p.T751M	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	752	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						GTTGCATTTACGTCAGACATC	0.363													T	22296134	T	T	22296134	3	4	270	1	0	0	0	0	1	0	0	0	700	536	19	1	2333	1	ANO5	11	22296134	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	17906882	22296134	112710382	31	19349											
OR8K3	219473	broad.mit.edu	37	chr11	56085826	56085826	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgaatgaattcattcttaCgggaatcacagatatcgctg	10	7	3	3	rs149952066		TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr11:56085826C>T	uc010rjf.1	+	1	44	c.44C>T	c.(43-45)ACG>ATG	p.T15M		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					TTCATTCTTACGGGAATCACA	0.423													T	56085826	T	T	56085826	3	4	270	1	0	0	0	0	1	0	0	0	11244	536	19	1	46	1	OR8K3	11	56085826	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	33789692	56085826	78920690	32	19350											
MS4A12	54860	broad.mit.edu	37	chr11	60264794	60264794	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	tgtgatacttaggacataatGatgtcatccaagccaacaag	8	8	1	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr11:60264794G>C	uc001npr.2	+	2	60	c.3G>C	c.(1-3)ATG>ATC	p.M1I	MS4A12_uc009ynb.2_Missense_Mutation_p.M1I	NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member	1	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						AGGACATAATGATGTCATCCA	0.383													C	60264794	C	C	60264794	3	2	270	1	0	0	0	0	1	0	0	0	9856	1290	45	5	5	5	MS4A12	11	60264794	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08	4178968	60264794	74741722	33	19351											
PANX1	24145	broad.mit.edu	37	chr11	93911644	93911644	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agacttgaagtttatcatggAagaacttgacaaagtttaca	8	5	1	4			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr11:93911644A>T	uc001per.2	+	3	816	c.431A>T	c.(430-432)GAA>GTA	p.E144V	PANX1_uc001peq.2_Missense_Mutation_p.E144V	NM_015368	NP_056183	Q96RD7	PANX1_HUMAN	pannexin 1	144	Cytoplasmic (Potential).				positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTTATCATGGAAGAACTTGAC	0.502													T	93911644	T	T	93911644	3	4	270	1	0	0	0	0	1	0	0	0	11420	246	9	5	441	5	PANX1	11	93911644	Missense_Mutation	SNP	A	TCGA-76-6282-01A-11D-1696-08	33646850	93911644	41094872	34	19352											
UBE4A	9354	broad.mit.edu	37	chr11	118255613	118255613	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cacttttcctccgctttcttAacctgctaatgaatgatgcc	5	13	1	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr11:118255613A>T	uc001psw.2	+	15	2494	c.2365A>T	c.(2365-2367)AAC>TAC	p.N789Y	UBE4A_uc001psv.2_Missense_Mutation_p.N796Y	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	789					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		CCGCTTTCTTAACCTGCTAAT	0.373													T	118255613	T	T	118255613	3	4	270	1	0	0	0	0	1	0	0	0	16879	362	13	5	2440	5	UBE4A	11	118255613	Missense_Mutation	SNP	A	TCGA-76-6282-01A-11D-1696-08	24343969	118255613	16750903	35	19353											
ITPR2	3709	broad.mit.edu	37	chr12	26868282	26868282	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcagaagtagctgattggcGcaaggtcgtacgaaggaaaa	14	6	0	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr12:26868282G>A	uc001rhg.2	-	8	1222	c.805C>T	c.(805-807)CGC>TGC	p.R269C		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	269	Cytoplasmic (Potential).|MIR 3.|Inositol-1,4,5-triphosphate binding (By similarity).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					GCTGATTGGCGCAAGGTCGTA	0.363													A	26868282	A	A	26868282	3	1	270	1	0	0	0	0	1	0	0	0	7921	1087	38	1	7500	1	ITPR2	12	26868282	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08		26868282	106983613	36	19354											
MTUS2	23281	broad.mit.edu	37	chr13	29600584	29600584	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgcacgcttgttgaacacGtcccccaaagtgcctgacaa	9	13	0	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr13:29600584G>A	uc001usl.3	+	1	1837	c.1779G>A	c.(1777-1779)ACG>ACA	p.T593T		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	583						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TGTTGAACACGTCCCCCAAAG	0.552													A	29600584	A	A	29600584	2	1	270	1	0	0	0	0	0	0	0	1	9966	1132	40	1		1	MTUS2	13	29600584	Silent	SNP	G	TCGA-76-6282-01A-11D-1696-08		29600584	85569294	37	19355											
OTX2	5015	broad.mit.edu	37	chr14	57269020	57269020	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	actttgttttgacctccattCtgctgttgttgctgttgttg	9	8	1	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr14:57269020C>A	uc001xcp.2	-	3	474	c.303G>T	c.(301-303)CAG>CAT	p.Q101H	OTX2_uc010aou.2_Missense_Mutation_p.Q101H|OTX2_uc001xcq.2_Missense_Mutation_p.Q109H	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	101	Poly-Gln.				axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					GACCTCCATTCTGCTGTTGTT	0.448													A	57269020	A	A	57269020	3	1	270	1	0	0	0	0	1	0	0	0	11321	912	32	5	570	5	OTX2	14	57269020	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08		57269020	50080520	38	19356											
VPS18	57617	broad.mit.edu	37	chr15	41193044	41193044	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgtatgcccgtggccggccGgactcactactggcctatct	11	15	2	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr15:41193044G>A	uc001zne.2	+	4	2367	c.2028G>A	c.(2026-2028)CCG>CCA	p.P676P		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	676	Clathrin.				endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GTGGCCGGCCGGACTCACTAC	0.647													A	41193044	A	A	41193044	2	1	270	1	0	0	0	0	0	0	0	1	17191	1103	39	2		2	VPS18	15	41193044	Silent	SNP	G	TCGA-76-6282-01A-11D-1696-08		41193044	61338348	39	19357											
SLC27A2	11001	broad.mit.edu	37	chr15	50475097	50475097	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ggcgaaggtgctgctggtgtCgccaggtgagccccgaggat	18	10	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr15:50475097C>T	uc001zxw.2	+	1	705	c.473C>T	c.(472-474)TCG>TTG	p.S158L	SLC27A2_uc010bes.2_Missense_Mutation_p.S158L	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	158	Lumenal (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		CTGCTGGTGTCGCCAGGTGAG	0.652													T	50475097	T	T	50475097	3	4	270	1	0	0	0	0	1	0	0	0	14526	893	31	2	475	2	SLC27A2	15	50475097	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	9282053	50475097	52056295	40	19358											
ITGA11	22801	broad.mit.edu	37	chr15	68641185	68641185	+	Frame_Shift_Del	DEL	A	-	-													tacctccaccacgtgcgaggAaaagcccgtctgtgacatct							TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr15:68641185delA	uc002ari.2	-	10	1201	c.1114delT	c.(1114-1116)TCCfs	p.S372fs	ITGA11_uc010bib.2_Frame_Shift_Del_p.S372fs	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	372	FG-GAP 3.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	ACGTGCGAGGAAAAGCCCGTC	0.562													-	68641185	-	-	68641185	7	5	270	1	0	1	0	1	0	0	0	0	7874	246	9	0	2536	0	ITGA11	15	68641185	Frame_Shift_Del	DEL	A	TCGA-76-6282-01A-11D-1696-08	18166088	68641185	33890207	41	19359											
TARSL2	123283	broad.mit.edu	37	chr15	102242566	102242566	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgtttccatttccggattgCcctcccaatatgttgaggaa	8	10	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr15:102242566C>T	uc002bxm.2	-	9	1152	c.1097G>A	c.(1096-1098)GGC>GAC	p.G366D	TARSL2_uc002bxl.2_5'UTR|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	366					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCCGGATTGCCCTCCCAATA	0.353													T	102242566	T	T	102242566	3	4	270	1	0	0	0	0	1	0	0	0	15558	739	26	3	1355	3	TARSL2	15	102242566	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	33601381	102242566	288826	42	19360											
MSLNL	401827	broad.mit.edu	37	chr16	830269	830269	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggtctgcttgaggccagaGgacatggaggaacttctgga	17	7	2	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr16:830269G>A	uc002cjz.1	-	3	732	c.732C>T	c.(730-732)TCC>TCT	p.S244S		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:Variant_position_missing_in_Q96KJ4_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						TGAGGCCAGAGGACATGGAGG	0.677													A	830269	A	A	830269	2	1	270	1	0	0	0	0	0	0	0	1	9882	987	35	3		3	MSLNL	16	830269	Silent	SNP	G	TCGA-76-6282-01A-11D-1696-08		830269	89524484	43	19361											
SRRM2	23524	broad.mit.edu	37	chr16	2812977	2812977	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acgccacccagacgcagtcgCtccagttcttctccgccacc	7	20	2	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr16:2812977C>T	uc002crk.2	+	11	2997	c.2448C>T	c.(2446-2448)CGC>CGT	p.R816R	SRRM2_uc002crj.1_Silent_p.R720R|SRRM2_uc002crl.1_Silent_p.R816R|SRRM2_uc010bsu.1_Silent_p.R720R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	816	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GACGCAGTCGCTCCAGTTCTT	0.498													T	2812977	T	T	2812977	2	4	270	1	0	0	0	0	0	0	0	1	15168	784	28	3		3	SRRM2	16	2812977	Silent	SNP	C	TCGA-76-6282-01A-11D-1696-08	1982708	2812977	87541776	44	19362											
SRRM2	23524	broad.mit.edu	37	chr16	2813966	2813966	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtctgactcttcttcatatcCtacagtggactcgaattctc	6	12	5	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr16:2813966C>G	uc002crk.2	+	11	3986	c.3437C>G	c.(3436-3438)CCT>CGT	p.P1146R	SRRM2_uc002crj.1_Missense_Mutation_p.P1050R|SRRM2_uc002crl.1_Missense_Mutation_p.P1146R|SRRM2_uc010bsu.1_Missense_Mutation_p.P1050R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1146	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCTTCATATCCTACAGTGGAC	0.468													G	2813966	G	G	2813966	3	3	270	1	0	0	0	0	1	0	0	0	15168	681	24	5	3475	5	SRRM2	16	2813966	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	989	2813966	87540787	45	19363											
GRIN2A	2903	broad.mit.edu	37	chr16	9857538	9857538	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttatcgtaggaatgctgaCggctaatccttagcttgttc	10	8	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr16:9857538C>T	uc002czo.3	-	13	4411	c.3863G>A	c.(3862-3864)CGT>CAT	p.R1288H	GRIN2A_uc010uym.1_Missense_Mutation_p.R1288H|GRIN2A_uc010uyn.1_Intron|GRIN2A_uc002czr.3_Intron	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1288	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGAATGCTGACGGCTAATCCT	0.537													T	9857538	T	T	9857538	3	4	270	1	0	0	0	0	1	0	0	0	6779	536	19	1	535	1	GRIN2A	16	9857538	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	7043572	9857538	80497215	46	19364											
MYH13	8735	broad.mit.edu	37	chr17	10233822	10233822	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctcctccaaaagtcccaggaGcccagctttgaaaaacacct	6	15	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr17:10233822G>T	uc002gmk.1	-	21	2407	c.2317C>A	c.(2317-2319)CTC>ATC	p.L773I		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	773	Myosin head-like.|Actin-binding (By similarity).				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						AGTCCCAGGAGCCCAGCTTTG	0.557													T	10233822	T	T	10233822	3	4	270	1	0	0	0	0	1	0	0	0	10032	971	34	5	3583	5	MYH13	17	10233822	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08		10233822	70961388	47	19365											
KRT33A	3883	broad.mit.edu	37	chr17	39506758	39506758	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgctgtgaccgctcccggaTgaggttctccagctccgcgt	12	15	1	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr17:39506758T>G	uc002hwk.1	-	1	299	c.262A>C	c.(262-264)ATC>CTC	p.I88L		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	88	Coil 1A.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				CGCTCCCGGATGAGGTTCTCC	0.612													G	39506758	G	G	39506758	3	3	270	1	0	0	0	0	1	0	0	0	8469	1464	51	5	980	5	KRT33A	17	39506758	Missense_Mutation	SNP	T	TCGA-76-6282-01A-11D-1696-08	29272936	39506758	41688452	48	19366											
OTOP2	92736	broad.mit.edu	37	chr17	72923832	72923832	+	Frame_Shift_Del	DEL	C	-	-													gtggtggatgaatctgtgcaCcaatcccactcctacagcag							TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr17:72923832delC	uc010wrp.1	+	6	671	c.582delC	c.(580-582)CACfs	p.H194fs	OTOP2_uc002jmf.1_3'UTR	NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	194						integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					AATCTGTGCACCAATCCCACT	0.582													-	72923832	-	-	72923832	7	5	270	1	0	1	0	1	0	0	0	0	11306	506	18	0	596	0	OTOP2	17	72923832	Frame_Shift_Del	DEL	C	TCGA-76-6282-01A-11D-1696-08	33417074	72923832	8271378	49	19367											
DSC1	1823	broad.mit.edu	37	chr18	28723628	28723628	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aggtatactcacagaagtttCtgtgaaagatggtggattgt	12	4	2	3			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr18:28723628C>T	uc002kwn.2	-	8	1328	c.1066G>A	c.(1066-1068)GAA>AAA	p.E356K	DSC1_uc002kwm.2_Missense_Mutation_p.E356K	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	356	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ACAGAAGTTTCTGTGAAAGAT	0.358													T	28723628	T	T	28723628	3	4	270	1	0	0	0	0	1	0	0	0	4765	922	32	3	1694	3	DSC1	18	28723628	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08		28723628	49353620	50	19368											
TNFSF9	8744	broad.mit.edu	37	chr19	6535006	6535006	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctggcagcttacccagggcGccacagtcttgggactcttc	11	15	2	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr19:6535006G>A	uc002mfh.2	+	3	732	c.694G>A	c.(694-696)GCC>ACC	p.A232T		NM_003811	NP_003802	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily,	232	Extracellular (Potential).				apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						TACCCAGGGCGCCACAGTCTT	0.662													A	6535006	A	A	6535006	3	1	270	1	0	0	0	0	1	0	0	0	16309	1087	38	1	704	1	TNFSF9	19	6535006	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08		6535006	52593977	51	19369											
MUC16	94025	broad.mit.edu	37	chr19	9049297	9049297	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atagttgaagttggaatggcCgaacttgtctgtgcttcagg	13	6	2	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr19:9049297C>T	uc002mkp.2	-	5	32538	c.32334G>A	c.(32332-32334)TCG>TCA	p.S10778S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10780	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGGAATGGCCGAACTTGTCT	0.468													T	9049297	T	T	9049297	2	4	270	1	0	0	0	0	0	0	0	1	9973	639	23	2		2	MUC16	19	9049297	Silent	SNP	C	TCGA-76-6282-01A-11D-1696-08	2514291	9049297	50079686	52	19370											
ZNF536	9745	broad.mit.edu	37	chr19	31039659	31039659	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cagtcaactgcaaagaccaaGcccgggaggcgagtaagatg	13	10	1	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr19:31039659G>T	uc002nsu.1	+	4	3271	c.3133G>T	c.(3133-3135)GCC>TCC	p.A1045S	ZNF536_uc010edd.1_Missense_Mutation_p.A1045S	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1045					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CAAAGACCAAGCCCGGGAGGC	0.537													T	31039659	T	T	31039659	3	4	270	1	0	0	0	0	1	0	0	0	17971	971	34	5	3143	5	ZNF536	19	31039659	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08	21990362	31039659	28089324	53	19371											
CD22	933	broad.mit.edu	37	chr19	35828889	35828889	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtctccaatgacgtgggccCgggaaggtcggaagaagtgt	17	8	1	2			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr19:35828889C>T	uc010edt.2	+	5	1027	c.950C>T	c.(949-951)CCG>CTG	p.P317L	CD22_uc010xst.1_Missense_Mutation_p.P145L|CD22_uc010edu.2_Missense_Mutation_p.P317L|CD22_uc010edv.2_Missense_Mutation_p.P317L|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	317	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GACGTGGGCCCGGGAAGGTCG	0.602													T	35828889	T	T	35828889	3	4	270	1	0	0	0	0	1	0	0	0	2985	652	23	2	964	2	CD22	19	35828889	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08	4789230	35828889	23300094	54	19372											
SHKBP1	92799	broad.mit.edu	37	chr19	41096902	41096902	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cctccactcagcctccagcaAcacctccttgtctggccacc	5	21	2	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr19:41096902A>G	uc002oob.2	+	18	1962	c.1913A>G	c.(1912-1914)AAC>AGC	p.N638S	SHKBP1_uc002ooc.2_Missense_Mutation_p.N613S|SHKBP1_uc002ood.2_Missense_Mutation_p.N546S|SHKBP1_uc002ooe.2_Missense_Mutation_p.N475S|SHKBP1_uc002oof.2_Missense_Mutation_p.N474S|SHKBP1_uc010xvm.1_Missense_Mutation_p.N418S|SHKBP1_uc010xvn.1_Missense_Mutation_p.N516S|LTBP4_uc002oog.1_5'Flank	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	638						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCTCCAGCAACACCTCCTTG	0.662													G	41096902	G	G	41096902	3	3	270	1	0	0	0	0	1	0	0	0	14284	43	2	4	1983	4	SHKBP1	19	41096902	Missense_Mutation	SNP	A	TCGA-76-6282-01A-11D-1696-08	5268013	41096902	18032081	55	19373											
PLCG1	5335	broad.mit.edu	37	chr20	39794468	39794468	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	actacacgctctctttctggTaacacttcccatgcagatgc	6	14	2	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr20:39794468T>C	uc002xjp.1	+	16	1920	c.1799_splice	c.e16+2	p.W600_splice	PLCG1_uc002xjo.1_Splice_Site_p.W600_splice|PLCG1_uc010zwe.1_Splice_Site_p.W226_splice|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b						activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				CTCTTTCTGGTAACACTTCCC	0.522													C	39794468	C	C	39794468	5	2	270	1	0	0	0	0	0	0	1	0	12035	1652	57	4	1863	4	PLCG1	20	39794468	Splice_Site	SNP	T	TCGA-76-6282-01A-11D-1696-08		39794468	23231052	56	19374											
TPTE	7179	broad.mit.edu	37	chr21	10933879	10933879	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcctttacagtgaatcgctaCgatgttttcaagatcttgag	8	8	2	3	rs149228869		TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr21:10933879C>T	uc002yip.1	-	17	1368	c.1000G>A	c.(1000-1002)GTA>ATA	p.V334I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.V316I|TPTE_uc002yir.1_Missense_Mutation_p.V296I|TPTE_uc010gkv.1_Missense_Mutation_p.V196I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	334	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGAATCGCTACGATGTTTTCA	0.313													T	10933879	T	T	10933879	3	4	270	1	0	0	0	0	1	0	0	0	16427	536	19	1	687	1	TPTE	21	10933879	Missense_Mutation	SNP	C	TCGA-76-6282-01A-11D-1696-08		10933879	37196016	57	19375											
RRP1B	23076	broad.mit.edu	37	chr21	45107849	45107849	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaacttggagttgtgcccGtcaatggcagtggcctgtcc	14	10	1	0			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr21:45107849G>A	uc002zdk.2	+	13	1708	c.1594G>A	c.(1594-1596)GTC>ATC	p.V532I	RRP1B_uc002zdl.2_Missense_Mutation_p.V65I	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	532					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		AGTTGTGCCCGTCAATGGCAG	0.647													A	45107849	A	A	45107849	3	1	270	1	0	0	0	0	1	0	0	0	13688	1145	40	1	1644	1	RRP1B	21	45107849	Missense_Mutation	SNP	G	TCGA-76-6282-01A-11D-1696-08	34173970	45107849	3022046	58	19376											
RGL4	266747	broad.mit.edu	37	chr22	24034585	24034585	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcagtttactatcagcccccGcaacggtcatctttccggat	7	14	4	0	rs141395325	byFrequency	TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr22:24034585G>A	uc002zxn.2	+	2	1413	c.243G>A	c.(241-243)CCG>CCA	p.P81P	LOC91316_uc002zxh.3_RNA|LOC91316_uc002zxi.3_RNA|LOC91316_uc002zxk.3_Intron|LOC91316_uc010gua.2_Intron|LOC91316_uc002zxl.3_Intron|LOC91316_uc011aiz.1_Intron|LOC91316_uc002zxm.3_Intron|RGL4_uc002zxo.2_Silent_p.P81P|RGL4_uc002zxp.1_5'UTR|RGL4_uc002zxq.2_5'UTR	NM_153615	NP_705843	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation	81					small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			ovary(1)	1						ATCAGCCCCCGCAACGGTCAT	0.552													A	24034585	A	A	24034585	2	1	270	1	0	0	0	0	0	0	0	1	13279	1074	38	1		1	RGL4	22	24034585	Silent	SNP	G	TCGA-76-6282-01A-11D-1696-08		24034585	27269981	59	19377											
MYO18B	84700	broad.mit.edu	37	chr22	26423542	26423542	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggaatcccacgacttgcGggtgacggtggcgagcgaac	15	12	0	1			TCGA-76-6282-01A-11D-1696-08	TCGA-76-6282-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	1c7f63d2-a2a4-42c3-928b-319695a66443	6223ac60-7bde-4229-ae1e-af4c3c2a6667	g.chr22:26423542G>A	uc003abz.1	+	43	7852	c.7602G>A	c.(7600-7602)GCG>GCA	p.A2534A	MYO18B_uc003aca.1_Silent_p.A2415A|MYO18B_uc010guy.1_Silent_p.A2416A|MYO18B_uc010guz.1_Silent_p.A2414A|MYO18B_uc011aka.1_Silent_p.A1688A|MYO18B_uc011akb.1_Silent_p.A2047A|MYO18B_uc010gva.1_Silent_p.A517A|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2534						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CACGACTTGCGGGTGACGGTG	0.572													A	26423542	A	A	26423542	2	1	270	1	0	0	0	0	0	0	0	1	10066	1103	39	2		2	MYO18B	22	26423542	Silent	SNP	G	TCGA-76-6282-01A-11D-1696-08	2388957	26423542	24881024	60	19378											
VPS13D	55187	broad.mit.edu	37	chr1	12414081	12414081	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tccagattatatgccctcaaAcatattttctgacagtgcaa	5	10	2	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:12414081A>G	uc001atv.2	+	47	9623	c.9482A>G	c.(9481-9483)AAC>AGC	p.N3161S	VPS13D_uc001atw.2_Missense_Mutation_p.N3136S|VPS13D_uc001atx.2_Missense_Mutation_p.N2348S	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3160					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ATGCCCTCAAACATATTTTCT	0.363													G	12414081	G	G	12414081	3	3	271	1	0	0	0	0	1	0	0	0	17189	43	2	4	9664	4	VPS13D	1	12414081	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08		12414081	236836540	1	19379											
HSPB7	27129	broad.mit.edu	37	chr1	16342135	16342135	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctgtatgcgggtgacgccgTgcccggatagtgaggctgcc	16	11	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:16342135T>C	uc001axo.2	-	3	1280	c.453A>G	c.(451-453)GCA>GCG	p.A151A	HSPB7_uc001axp.2_Silent_p.A234A|HSPB7_uc001axq.2_Silent_p.A243A|HSPB7_uc001axr.2_Silent_p.A244A|HSPB7_uc001axs.2_Silent_p.A226A	NM_014424	NP_055239	Q9UBY9	HSPB7_HUMAN	cardiovascular heat shock protein	151					regulation of heart contraction|response to heat|response to unfolded protein	Cajal body	protein C-terminus binding				0		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.21e-08)|COAD - Colon adenocarcinoma(227;5.5e-06)|BRCA - Breast invasive adenocarcinoma(304;9.08e-05)|Kidney(64;0.000162)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00656)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGACGCCGTGCCCGGATAG	0.642													C	16342135	C	C	16342135	2	2	271	1	0	0	0	0	0	0	0	1	7422	1683	59	4		4	HSPB7	1	16342135	Silent	SNP	T	TCGA-76-6283-01A-11D-1845-08	3928054	16342135	232908486	2	19380											
EPHA8	2046	broad.mit.edu	37	chr1	22927421	22927421	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtggaggaggggtaccgcCtgcccgcacccatgggctgc	16	14	0	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:22927421C>T	uc001bfx.1	+	15	2694	c.2569C>T	c.(2569-2571)CTG>TTG	p.L857L		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	857	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GGGGTACCGCCTGCCCGCACC	0.697													T	22927421	T	T	22927421	2	4	271	1	0	0	0	0	0	0	0	1	5173	680	24	3		3	EPHA8	1	22927421	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	6585286	22927421	226323200	3	19381											
PHACTR4	65979	broad.mit.edu	37	chr1	28818258	28818258	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgctcaagattatgaccggCgagccgacaaaccttggacc	10	12	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:28818258C>T	uc001bpw.2	+	12	2257	c.1975C>T	c.(1975-1977)CGA>TGA	p.R659*	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Nonsense_Mutation_p.R643*|PHACTR4_uc001bpy.2_Nonsense_Mutation_p.R669*|PHACTR4_uc001bpz.2_RNA	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	659							actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TTATGACCGGCGAGCCGACAA	0.398													T	28818258	T	T	28818258	4	4	271	1	0	0	0	0	0	1	0	0	11812	760	27	1	2067	1	PHACTR4	1	28818258	Nonsense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	5890837	28818258	220432363	4	19382											
IPP	3652	broad.mit.edu	37	chr1	46165793	46165793	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acctccagaaacatacagaaGaccattgactgccacaacac	5	14	0	4	rs147854966		TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:46165793G>C	uc001cou.2	-	9	1867	c.1600C>G	c.(1600-1602)CTT>GTT	p.L534V	IPP_uc001cos.3_Missense_Mutation_p.L534V	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	534						actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACATACAGAAGACCATTGACT	0.423													C	46165793	C	C	46165793	3	2	271	1	0	0	0	0	1	0	0	0	7800	942	33	5	260	5	IPP	1	46165793	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	17347535	46165793	203084828	5	19383											
GADD45A	1647	broad.mit.edu	37	chr1	68152267	68152267	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gacctgcactgcgtgctggtGacggtaagggactgggggac	18	9	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:68152267G>T	uc001ddz.1	+	3	676	c.381G>T	c.(379-381)GTG>GTT	p.V127V	GADD45A_uc009wbb.1_Silent_p.V93V|GADD45A_uc009wbc.1_Intron|GADD45A_uc009wbd.1_Intron	NM_001924	NP_001915	P24522	GA45A_HUMAN	growth arrest and DNA-damage-inducible, alpha	127					apoptosis|cell cycle arrest|cellular response to ionizing radiation|cellular response to mechanical stimulus|DNA repair|positive regulation of reactive oxygen species metabolic process|regulation of cyclin-dependent protein kinase activity|signal transduction in response to DNA damage	nucleus	protein binding			ovary(1)	1						GCGTGCTGGTGACGGTAAGGG	0.706													T	68152267	T	T	68152267	2	4	271	1	0	0	0	0	0	0	0	1	6181	1277	45	5		5	GADD45A	1	68152267	Silent	SNP	G	TCGA-76-6283-01A-11D-1845-08	21986474	68152267	181098354	6	19384											
ABCA4	24	broad.mit.edu	37	chr1	94522271	94522271	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgctgccagactggccttGgagaagaaggtgctgagcag	16	9	0	4			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:94522271G>A	uc001dqh.2	-	15	2372	c.2268C>T	c.(2266-2268)TCC>TCT	p.S756S	ABCA4_uc010otn.1_Intron	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	756					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GACTGGCCTTGGAGAAGAAGG	0.542													A	94522271	A	A	94522271	2	1	271	1	0	0	0	0	0	0	0	1	34	1335	47	3		3	ABCA4	1	94522271	Silent	SNP	G	TCGA-76-6283-01A-11D-1845-08	26370004	94522271	154728350	7	19385											
CGN	57530	broad.mit.edu	37	chr1	151491406	151491406	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagctactccgttcccactcCcaggcctcactggcaggccc	8	19	1	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:151491406C>T	uc009wmw.2	+	2	555	c.411C>T	c.(409-411)TCC>TCT	p.S137S		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	131	Interacts with ZO-2.|Head.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTTCCCACTCCCAGGCCTCAC	0.592													T	151491406	T	T	151491406	2	4	271	1	0	0	0	0	0	0	0	1	3303	610	22	3		3	CGN	1	151491406	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	56969135	151491406	97759215	8	19386											
S100A14	57402	broad.mit.edu	37	chr1	153587428	153587428	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctccaatcagctcccagaaaCtcctgaactccagtttagag	6	14	1	3			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:153587428C>G	uc001fce.2	-	4	346	c.248G>C	c.(247-249)AGT>ACT	p.S83T	S100A16_uc001fcd.1_5'Flank	NM_020672	NP_065723	Q9HCY8	S10AE_HUMAN	S100 calcium binding protein A14	83	2; high affinity (Potential).				calcium ion homeostasis|defense response to bacterium|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|response to lipopolysaccharide|toll-like receptor 4 signaling pathway	cell junction|microtubule cytoskeleton|perinuclear region of cytoplasm	calcium ion binding|chemokine receptor binding				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTCCCAGAAACTCCTGAACTC	0.557													G	153587428	G	G	153587428	3	3	271	1	0	0	0	0	1	0	0	0	13776	565	20	5	70	5	S100A14	1	153587428	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	2096022	153587428	95663193	9	19387											
NUP210L	91181	broad.mit.edu	37	chr1	153973356	153973356	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	acccaacttatctttcatagCcctcactaccactgcctcac	2	18	4	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:153973356C>A	uc001fdw.2	-	37	5434	c.5362G>T	c.(5362-5364)GCT>TCT	p.A1788S	NUP210L_uc009woq.2_Missense_Mutation_p.A697S|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1788						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TCTTTCATAGCCCTCACTACC	0.363													A	153973356	A	A	153973356	3	1	271	1	0	0	0	0	1	0	0	0	10761	739	26	5	320	5	NUP210L	1	153973356	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	385928	153973356	95277265	10	19388											
PYHIN1	149628	broad.mit.edu	37	chr1	158914677	158914677	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	actttcagatacagaaaaatAcaaaccagagaagccatgac	6	9	1	4			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:158914677A>G	uc001ftb.2	+	7	1449	c.1204A>G	c.(1204-1206)ACA>GCA	p.T402A	PYHIN1_uc001ftc.2_Missense_Mutation_p.T393A|PYHIN1_uc001ftd.2_Missense_Mutation_p.T402A|PYHIN1_uc001fte.2_Missense_Mutation_p.T393A	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	402					cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					ACAGAAAAATACAAACCAGAG	0.373													G	158914677	G	G	158914677	3	3	271	1	0	0	0	0	1	0	0	0	12865	391	14	4	1226	4	PYHIN1	1	158914677	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08	4941321	158914677	90335944	11	19389											
C1orf125	126859	broad.mit.edu	37	chr1	179364322	179364322	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcacaagctcttttaaatgCggaaaagaatgccaagtgag	11	7	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:179364322C>T	uc001gmo.2	+	11	1221	c.1094C>T	c.(1093-1095)GCG>GTG	p.A365V	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Missense_Mutation_p.A153V|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.A365V	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	365	Potential.										0						CTTTTAAATGCGGAAAAGAAT	0.353													T	179364322	T	T	179364322	3	4	271	1	0	0	0	0	1	0	0	0	1993	768	27	1	1132	1	C1orf125	1	179364322	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	20449645	179364322	69886299	12	19390											
HMCN1	83872	broad.mit.edu	37	chr1	186134268	186134268	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgcagtaatcagtgcccctcCgggtttaccttagactcagt	9	13	2	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:186134268C>T	uc001grq.1	+	98	15511	c.15282C>T	c.(15280-15282)TCC>TCT	p.S5094S	HMCN1_uc001grs.1_Silent_p.S663S	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5094					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGTGCCCCTCCGGGTTTACCT	0.388													T	186134268	T	T	186134268	2	4	271	1	0	0	0	0	0	0	0	1	7220	639	23	2		2	HMCN1	1	186134268	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	6769946	186134268	63116353	13	19391											
FCAMR	83953	broad.mit.edu	37	chr1	207140441	207140441	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaggggcattttccatcccGccctcctgctggtgacctgc	11	15	0	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:207140441G>A	uc001hfa.3	-	3	625	c.125C>T	c.(124-126)GCG>GTG	p.A42V	FCAMR_uc001hfb.2_Missense_Mutation_p.A42V|FCAMR_uc009xca.1_Missense_Mutation_p.A42V|FCAMR_uc001hfc.2_Intron	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane|plasma membrane	receptor activity			ovary(1)	1						TTTCCATCCCGCCCTCCTGCT	0.527													A	207140441	A	A	207140441	3	1	271	1	0	0	0	0	1	0	0	0	5772	1087	38	1	1632	1	FCAMR	1	207140441	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	21006173	207140441	42110180	14	19392											
USH2A	7399	broad.mit.edu	37	chr1	215848243	215848243	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggtggagcatcctccactcGtgcaggcttggagtgcatag	14	10	0	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:215848243G>A	uc001hku.1	-	63	13397	c.13010C>T	c.(13009-13011)ACG>ATG	p.T4337M		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4337	Fibronectin type-III 28.|Extracellular (Potential).		T -> M (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCCTCCACTCGTGCAGGCTTG	0.498										HNSCC(13;0.011)			A	215848243	A	A	215848243	3	1	271	1	0	0	0	0	1	0	0	0	17033	1145	40	1	2638	1	USH2A	1	215848243	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	8707802	215848243	33402378	15	19393											
USH2A	7399	broad.mit.edu	37	chr1	216538373	216538373	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagagttcttgcattgaaagGtgtatgatccttctccacgc	9	9	2	3			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:216538373G>A	uc001hku.1	-	4	1093	c.706C>T	c.(706-708)CCT>TCT	p.P236S	USH2A_uc001hkv.2_Missense_Mutation_p.P236S	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	236	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCATTGAAAGGTGTATGATCC	0.353										HNSCC(13;0.011)			A	216538373	A	A	216538373	3	1	271	1	0	0	0	0	1	0	0	0	17033	1261	44	3	15192	3	USH2A	1	216538373	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	690130	216538373	32712248	16	19394											
OR2T33	391195	broad.mit.edu	37	chr1	248436840	248436840	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gatctgcacaccacagccagCgcgggagatggccttacttc	11	14	1	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr1:248436840C>T	uc010pzi.1	-	1	277	c.277G>A	c.(277-279)GCT>ACT	p.A93T		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCACAGCCAGCGCGGGAGATG	0.577													T	248436840	T	T	248436840	3	4	271	1	0	0	0	0	1	0	0	0	11024	768	27	1	688	1	OR2T33	1	248436840	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	31898467	248436840	813781	17	19395											
IAH1	285148	broad.mit.edu	37	chr2	9628296	9628296	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gacttctcatcttatttatcAgatggactacatttgtctcc	5	10	4	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr2:9628296A>G	uc002qzr.2	+	6	611	c.585A>G	c.(583-585)TCA>TCG	p.S195S	IAH1_uc002qzs.2_Silent_p.S82S|IAH1_uc002qzt.2_Silent_p.S82S|IAH1_uc010yiz.1_RNA	NM_001039613	NP_001034702	Q2TAA2	IAH1_HUMAN	isoamyl acetate-hydrolyzing esterase 1 homolog	195					lipid catabolic process		hydrolase activity, acting on ester bonds				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTTATTTATCAGATGGACTAC	0.318													G	9628296	G	G	9628296	2	3	271	1	0	0	0	0	0	0	0	1	7471	175	7	4		4	IAH1	2	9628296	Silent	SNP	A	TCGA-76-6283-01A-11D-1845-08		9628296	233571077	18	19396											
TTN	7273	broad.mit.edu	37	chr2	179542390	179542392	+	In_Frame_Del	DEL	CTT	-	-													aggtttaacttctggaaggaCttcttcttcaggtacaaatt							TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr2:179542390_179542392delCTT	uc010zfg.1	-	143	30739_30741	c.30515_30517delAAG	c.(30514-30519)GAAGTC>GTC	p.E10172del	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_In_Frame_Del_p.E6833del|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11099							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGGAAGGACTTCTTCTTCAGG	0.443													-	179542392	-	-	179542390	7	5	271	1	0	1	0	1	0	0	0	0	16732	565	20	0	70148	0	TTN	2	179542390	In_Frame_Del	DEL	CTT	TCGA-76-6283-01A-11D-1845-08	169914094	179542390	63656983	19	19397											
COL3A1	1281	broad.mit.edu	37	chr2	189859008	189859008	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gactgatgggagcccggggtCctccaggaccagccggtgct	16	13	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr2:189859008C>T	uc002uqj.1	+	18	1360	c.1243C>T	c.(1243-1245)CCT>TCT	p.P415S	COL3A1_uc010frw.1_RNA	NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	415	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AGCCCGGGGTCCTCCAGGACC	0.498													T	189859008	T	T	189859008	3	4	271	1	0	0	0	0	1	0	0	0	3688	855	30	3	1313	3	COL3A1	2	189859008	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	10316618	189859008	53340365	20	19398											
NUP210	23225	broad.mit.edu	37	chr3	13427820	13427820	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgcaccttgtagtgaatggAggttcccaccatcaggtaga	11	10	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr3:13427820A>G	uc003bxv.1	-	6	855	c.772T>C	c.(772-774)TCC>CCC	p.S258P		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	258	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					TAGTGAATGGAGGTTCCCACC	0.463													G	13427820	G	G	13427820	3	3	271	1	0	0	0	0	1	0	0	0	10760	304	11	4	5031	4	NUP210	3	13427820	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08		13427820	184594610	21	19399											
NKTR	4820	broad.mit.edu	37	chr3	42678511	42678511	+	Frame_Shift_Del	DEL	A	-	-													aagaaaaaaaggttaagcatAaaaagaaagggaaaaagcag							TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr3:42678511delA	uc003clo.2	+	13	1462	c.1315delA	c.(1315-1317)AAAfs	p.K439fs	NKTR_uc003clm.1_Frame_Shift_Del_p.K186fs|NKTR_uc003clp.2_Frame_Shift_Del_p.K186fs|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Frame_Shift_Del_p.K329fs|NKTR_uc003clr.1_Frame_Shift_Del_p.K186fs|NKTR_uc003cls.2_Frame_Shift_Del_p.K139fs	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	439	Arg/Lys-rich (basic).				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GGTTAAGCATAAAAAGAAAGG	0.368													-	42678511	-	-	42678511	7	5	271	1	0	1	0	1	0	0	0	0	10448	363	13	0	1361	0	NKTR	3	42678511	Frame_Shift_Del	DEL	A	TCGA-76-6283-01A-11D-1845-08	29250691	42678511	155343919	22	19400											
ALAS1	211	broad.mit.edu	37	chr3	52242221	52242221	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcggagggattggggatcggGatggagtcatgccaaaaatg	18	5	1	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr3:52242221G>A	uc003dcy.1	+	9	1625	c.1288G>A	c.(1288-1290)GAT>AAT	p.D430N	ALAS1_uc003dcz.1_Missense_Mutation_p.D430N|ALAS1_uc011bec.1_Missense_Mutation_p.D447N	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	430					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TGGGGATCGGGATGGAGTCAT	0.483													A	52242221	A	A	52242221	3	1	271	1	0	0	0	0	1	0	0	0	484	1174	41	3	1314	3	ALAS1	3	52242221	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	9563710	52242221	145780209	23	19401											
DNAH1	25981	broad.mit.edu	37	chr3	52422839	52422839	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctcatcaacgggctgtcGgatgagaaggtgcgctggca	15	10	2	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr3:52422839G>A	uc011bef.1	+	59	9642	c.9381G>A	c.(9379-9381)TCG>TCA	p.S3127S	DNAH1_uc003ddv.2_5'UTR	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3192	Potential.				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACGGGCTGTCGGATGAGAAGG	0.667													A	52422839	A	A	52422839	2	1	271	1	0	0	0	0	0	0	0	1	4597	1103	39	2		2	DNAH1	3	52422839	Silent	SNP	G	TCGA-76-6283-01A-11D-1845-08	180618	52422839	145599591	24	19402											
SERPINI1	5274	broad.mit.edu	37	chr3	167525043	167525043	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttctccaggttcacagtggAacaggaaattgatttaaaag	10	6	2	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr3:167525043A>C	uc003ffa.3	+	6	1091	c.893A>C	c.(892-894)GAA>GCA	p.E298A	SERPINI1_uc003ffb.3_Missense_Mutation_p.E298A	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	298					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						TTCACAGTGGAACAGGAAATT	0.338													C	167525043	C	C	167525043	3	2	271	1	0	0	0	0	1	0	0	0	14118	246	9	5	911	5	SERPINI1	3	167525043	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08	115102204	167525043	30497387	25	19403											
ATP8A1	10396	broad.mit.edu	37	chr4	42581956	42581956	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatttgtacatttgtaatccGttccacatttgagagcttaa	6	7	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr4:42581956G>A	uc003gwr.2	-	11	1106	c.874C>T	c.(874-876)CGG>TGG	p.R292W	ATP8A1_uc003gws.2_Missense_Mutation_p.R292W|ATP8A1_uc011byz.1_Missense_Mutation_p.R292W	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	292	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	TTTGTAATCCGTTCCACATTT	0.343													A	42581956	A	A	42581956	3	1	271	1	0	0	0	0	1	0	0	0	1192	1144	40	1	2728	1	ATP8A1	4	42581956	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08		42581956	148572320	26	19404											
CENPE	1062	broad.mit.edu	37	chr4	104065619	104065619	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	aaggttttcatgtagtatctGagtcaaccttatattctccg	7	8	4	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr4:104065619G>A	uc003hxb.1	-	33	5104	c.5014C>T	c.(5014-5016)CAG>TAG	p.Q1672*	CENPE_uc003hxc.1_Nonsense_Mutation_p.Q1647*	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1672	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TGTAGTATCTGAGTCAACCTT	0.393													A	104065619	A	A	104065619	4	1	271	1	0	0	0	0	0	1	0	0	3230	1299	45	3	3159	3	CENPE	4	104065619	Nonsense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	61483663	104065619	87088657	27	19405											
KIAA1109	84162	broad.mit.edu	37	chr4	123184110	123184110	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctcagagaagcagtgctgcTgtgaaaagtagctccctaac	10	11	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr4:123184110T>C	uc003ieh.2	+	41	6999	c.6954T>C	c.(6952-6954)GCT>GCC	p.A2318A	KIAA1109_uc003iel.1_Silent_p.A253A|KIAA1109_uc003iek.2_Silent_p.A937A	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2318					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GCAGTGCTGCTGTGAAAAGTA	0.463													C	123184110	C	C	123184110	2	2	271	1	0	0	0	0	0	0	0	1	8208	1567	55	4		4	KIAA1109	4	123184110	Silent	SNP	T	TCGA-76-6283-01A-11D-1845-08	19118491	123184110	67970166	28	19406											
KIAA1109	84162	broad.mit.edu	37	chr4	123192519	123192519	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccttcaaaaccagaaaacatCgggactttcgttcatctgac	6	12	3	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr4:123192519C>T	uc003ieh.2	+	45	7885	c.7840C>T	c.(7840-7842)CGG>TGG	p.R2614W	KIAA1109_uc003iel.1_Missense_Mutation_p.R549W|KIAA1109_uc003iek.2_Missense_Mutation_p.R1233W	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2614					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CAGAAAACATCGGGACTTTCG	0.403													T	123192519	T	T	123192519	3	4	271	1	0	0	0	0	1	0	0	0	8208	875	31	2	8018	2	KIAA1109	4	123192519	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	8409	123192519	67961757	29	19407											
SLC10A7	84068	broad.mit.edu	37	chr4	147227117	147227117	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accacaacagtcataaaaagCtgagaaaaaatagatgtgaa	7	6	1	3			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr4:147227117C>T	uc010ioz.2	-	7	770	c.516G>A	c.(514-516)CAG>CAA	p.Q172Q	SLC10A7_uc003ikr.2_Silent_p.Q172Q|SLC10A7_uc010ipa.2_Silent_p.Q159Q|SLC10A7_uc003iks.2_RNA	NM_001029998	NP_001025169	Q0GE19	NTCP7_HUMAN	solute carrier family 10 (sodium/bile acid	172	Helical; (Potential).					integral to membrane	bile acid:sodium symporter activity				0	all_hematologic(180;0.151)					TCATAAAAAGCTGAGAAAAAA	0.338													T	147227117	T	T	147227117	2	4	271	1	0	0	0	0	0	0	0	1	14379	796	28	3		3	SLC10A7	4	147227117	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	24034598	147227117	43927159	30	19408											
ZFR	51663	broad.mit.edu	37	chr5	32388633	32388636	+	Frame_Shift_Del	DEL	CAGA	-	-													gttcttgttcttctcatgttCagacaaactgtctgaaacga							TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:32388633_32388636delCAGA	uc003jhr.1	-	13	2367_2370	c.2287_2290delTCTG	c.(2287-2292)TCTGAAfs	p.S763fs	ZFR_uc011cny.1_RNA	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	763_764					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		TTCTCATGTTCAGACAAACTGTCT	0.358													-	32388636	-	-	32388633	7	5	271	1	0	1	0	1	0	0	0	0	17656	835	29	0	966	0	ZFR	5	32388633	Frame_Shift_Del	DEL	CAGA	TCGA-76-6283-01A-11D-1845-08		32388633	148526627	31	19409											
ADAMTS12	81792	broad.mit.edu	37	chr5	33881270	33881270	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccgtcccaactctggtgcccTgctgtagaaccgtgccactg	10	16	1	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:33881270T>C	uc003jia.1	-	2	606	c.443A>G	c.(442-444)CAG>CGG	p.Q148R	ADAMTS12_uc010iuq.1_Missense_Mutation_p.Q148R|ADAMTS12_uc003jib.1_Missense_Mutation_p.Q148R	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	148					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCTGGTGCCCTGCTGTAGAAC	0.577										HNSCC(64;0.19)			C	33881270	C	C	33881270	3	2	271	1	0	0	0	0	1	0	0	0	257	1580	55	4	4433	4	ADAMTS12	5	33881270	Missense_Mutation	SNP	T	TCGA-76-6283-01A-11D-1845-08	1492637	33881270	147033990	32	19410											
GPR98	84059	broad.mit.edu	37	chr5	90046453	90046453	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttaaaaggaacatatggccGtataaccatagcatgggaag	10	7	0	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:90046453G>A	uc003kju.2	+	53	11156	c.11060G>A	c.(11059-11061)CGT>CAT	p.R3687H	GPR98_uc003kjt.2_Missense_Mutation_p.R1393H|GPR98_uc003kjv.2_Missense_Mutation_p.R1287H	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3687	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACATATGGCCGTATAACCATA	0.343													A	90046453	A	A	90046453	3	1	271	1	0	0	0	0	1	0	0	0	6721	1145	40	1	11270	1	GPR98	5	90046453	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	56165183	90046453	90868807	33	19411											
GPR98	84059	broad.mit.edu	37	chr5	90144497	90144497	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agctttcagtgttgccagccGaactcttttctatgagattc	8	10	3	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:90144497G>A	uc003kju.2	+	79	17159	c.17063G>A	c.(17062-17064)CGA>CAA	p.R5688Q	GPR98_uc003kjt.2_Missense_Mutation_p.R3394Q|GPR98_uc003kjw.2_Missense_Mutation_p.R1349Q	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5688	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTTGCCAGCCGAACTCTTTTC	0.313													A	90144497	A	A	90144497	3	1	271	1	0	0	0	0	1	0	0	0	6721	1058	37	2	17377	2	GPR98	5	90144497	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	98044	90144497	90770763	34	19412											
GPR98	84059	broad.mit.edu	37	chr5	90159635	90159635	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tactccatgtttgcagctaaActtctgactcacatgatggc	7	11	2	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:90159635A>T	uc003kju.2	+	83	17913	c.17817A>T	c.(17815-17817)AAA>AAT	p.K5939N	GPR98_uc003kjt.2_Missense_Mutation_p.K3645N|GPR98_uc003kjw.2_Missense_Mutation_p.K1600N	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5939	Cytoplasmic (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGCAGCTAAACTTCTGACTC	0.423													T	90159635	T	T	90159635	3	4	271	1	0	0	0	0	1	0	0	0	6721	40	2	5	18147	5	GPR98	5	90159635	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08	15138	90159635	90755625	35	19413											
EPB41L4A	64097	broad.mit.edu	37	chr5	111540130	111540130	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acaggaggggtttcggcgacGcgtgtaagggaactttggcg	18	7	0	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:111540130G>A	uc003kpv.1	-	15	1592	c.1318C>T	c.(1318-1320)CGT>TGT	p.R440C	EPB41L4A_uc003kpp.1_Missense_Mutation_p.R67C	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	440						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TTTCGGCGACGCGTGTAAGGG	0.488													A	111540130	A	A	111540130	3	1	271	1	0	0	0	0	1	0	0	0	5155	1087	38	1	778	1	EPB41L4A	5	111540130	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	21380495	111540130	69375130	36	19414											
ATG12	9140	broad.mit.edu	37	chr5	115177086	115177087	+	Splice_Site	INS	-	T	T													ccggaaataaattcagttacINStttttttcttggtgtcgcca							TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:115177086_115177087insT	uc003krh.2	-	1	413	c.304_splice	c.e1+1	p.I102_splice	AP3S1_uc003krl.2_5'Flank|AP3S1_uc003krk.2_5'Flank|AP3S1_uc003krm.2_5'Flank|ATG12_uc003kri.2_Splice_Site_p.I102_splice|ATG12_uc003krj.2_RNA	NM_004707	NP_004698	O94817	ATG12_HUMAN	APG12 autophagy 12-like						autophagic vacuole assembly|negative regulation of type I interferon production	pre-autophagosomal structure membrane	protein binding				0		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;7.59e-08)|Epithelial(69;7.05e-07)|all cancers(49;3.11e-05)		AATTCAGTTACTTTTTTTCTTG	0.55													T	115177087	T	T	115177086	8	5	271	1	0	1	1	0	0	0	1	0	1090	579	20	0	274	0	ATG12	5	115177086	Splice_Site	INS	-	TCGA-76-6283-01A-11D-1845-08	3636956	115177086	65738174	37	19415											
PRR16	51334	broad.mit.edu	37	chr5	120022105	120022105	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cagggcctcgagaacgagttCggtttaatgaaaaagtacag	12	7	0	2	rs137912065	byFrequency	TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:120022105C>T	uc003ksq.2	+	2	779	c.616C>T	c.(616-618)CGG>TGG	p.R206W	PRR16_uc003ksp.2_Missense_Mutation_p.R183W|PRR16_uc003ksr.2_Missense_Mutation_p.R136W	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	206	Pro-rich.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		AGAACGAGTTCGGTTTAATGA	0.473													T	120022105	T	T	120022105	3	4	271	1	0	0	0	0	1	0	0	0	12589	875	31	2	553	2	PRR16	5	120022105	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	4845019	120022105	60893155	38	19416											
CSNK1G3	1456	broad.mit.edu	37	chr5	122893189	122893189	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	tttgtttgtttttcaattagGagcccatgaaatcaagagca	8	6	2	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:122893189G>T	uc003ktm.2	+	4	939	c.220G>T	c.(220-222)GAG>TAG	p.E74*	CSNK1G3_uc003ktl.2_Nonsense_Mutation_p.E74*|CSNK1G3_uc003ktn.2_Nonsense_Mutation_p.E74*|CSNK1G3_uc003kto.2_Nonsense_Mutation_p.E74*|CSNK1G3_uc011cwr.1_5'UTR|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Nonsense_Mutation_p.E74*	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	74	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		TTTCAATTAGGAGCCCATGAA	0.299													T	122893189	T	T	122893189	4	4	271	1	0	0	0	0	0	1	0	0	3956	1188	41	5	230	5	CSNK1G3	5	122893189	Nonsense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	2871084	122893189	58022071	39	19417											
TRPC7	57113	broad.mit.edu	37	chr5	135693041	135693041	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctcagcgttgtgtgccggCgctgcatgtttttgaaggtg	14	10	1	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:135693041C>T	uc003lbn.1	-	1	35	c.32G>A	c.(31-33)CGC>CAC	p.R11H	TRPC7_uc010jef.1_Missense_Mutation_p.R3H|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.R3H|TRPC7_uc010jei.1_Missense_Mutation_p.R3H|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	12	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGTGTGCCGGCGCTGCATGTT	0.572													T	135693041	T	T	135693041	3	4	271	1	0	0	0	0	1	0	0	0	16581	768	27	1	2597	1	TRPC7	5	135693041	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	12799852	135693041	45222219	40	19418											
NDFIP1	80762	broad.mit.edu	37	chr5	141511419	141511419	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acctgaacaggctgcaggtgAtgctcctccaccttacagca	9	14	0	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:141511419A>G	uc003lmi.3	+	2	326	c.110A>G	c.(109-111)GAT>GGT	p.D37G	NDFIP1_uc003lmj.1_Missense_Mutation_p.D37G	NM_030571	NP_085048	Q9BT67	NFIP1_HUMAN	Nedd4 family interacting protein 1	37	Cytoplasmic (Potential).				cellular iron ion homeostasis|negative regulation of gene expression|negative regulation of protein transport|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of protein ubiquitination	endosome membrane|extracellular region|Golgi membrane|integral to membrane|perinuclear region of cytoplasm	signal transducer activity				0		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGCAGGTGATGCTCCTCCA	0.408													G	141511419	G	G	141511419	3	3	271	1	0	0	0	0	1	0	0	0	10245	333	12	4	116	4	NDFIP1	5	141511419	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08	5818378	141511419	39403841	41	19419											
GABRG2	2566	broad.mit.edu	37	chr5	161530925	161530925	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acgtgaagaaattgtttatcAatggaagcgaagttctgttg	11	4	2	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:161530925A>T	uc003lyz.3	+	6	1020	c.662A>T	c.(661-663)CAA>CTA	p.Q221L	GABRG2_uc010jjc.2_Missense_Mutation_p.Q261L|GABRG2_uc003lyy.3_Missense_Mutation_p.Q221L|GABRG2_uc011dej.1_Missense_Mutation_p.Q126L	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	221	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		ATTGTTTATCAATGGAAGCGA	0.388													T	161530925	T	T	161530925	3	4	271	1	0	0	0	0	1	0	0	0	6172	130	5	5	808	5	GABRG2	5	161530925	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08	20019506	161530925	19384335	42	19420											
BNIP1	662	broad.mit.edu	37	chr5	172585746	172585746	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgtgaaccttccaattccaGcaatcaggcctcatggagga	9	12	2	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:172585746G>A	uc003mcj.3	+	4	374	c.270_splice	c.e4-1	p.S90_splice	BNIP1_uc003mci.3_Splice_Site_p.S133_splice|BNIP1_uc003mck.3_Intron|BNIP1_uc003mcl.3_Intron	NM_001205	NP_001196	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 1						anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TCCAATTCCAGCAATCAGGCC	0.483													A	172585746	A	A	172585746	5	1	271	1	0	0	0	0	0	0	1	0	1476	985	34	3	416	3	BNIP1	5	172585746	Splice_Site	SNP	G	TCGA-76-6283-01A-11D-1845-08	11054821	172585746	8329514	43	19421											
CDHR2	54825	broad.mit.edu	37	chr5	176004494	176004494	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agtgggctcagcctccgttcAggtgctggtgagagtatccg	15	10	2	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr5:176004494A>G	uc003mem.1	+	13	1355	c.1289A>G	c.(1288-1290)CAG>CGG	p.Q430R	CDHR2_uc003men.1_Missense_Mutation_p.Q430R	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	430	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GCCTCCGTTCAGGTGCTGGTG	0.672													G	176004494	G	G	176004494	3	3	271	1	0	0	0	0	1	0	0	0	3119	188	7	4	1335	4	CDHR2	5	176004494	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08	3418748	176004494	4910766	44	19422											
DSP	1832	broad.mit.edu	37	chr6	7576615	7576615	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agtggctctatgatgctaaaCgccgccaggattccttagaa	10	10	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr6:7576615C>T	uc003mxp.1	+	19	2998	c.2719C>T	c.(2719-2721)CGC>TGC	p.R907C	DSP_uc003mxq.1_Missense_Mutation_p.R907C	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	907	Globular 1.|Spectrin 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGATGCTAAACGCCGCCAGGA	0.423													T	7576615	T	T	7576615	3	4	271	1	0	0	0	0	1	0	0	0	4781	536	19	1	2793	1	DSP	6	7576615	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08		7576615	163538452	45	19423											
TAP2	6891	broad.mit.edu	37	chr6	32798068	32798068	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ctgtgcaggtagcagtgttcAtactgtgagatgggcttttc	13	7	1	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr6:32798068A>G	uc003occ.2	-	8	1642	c.1611T>C	c.(1609-1611)TAT>TAC	p.Y537Y	TAP2_uc011dqf.1_Silent_p.Y537Y|TAP2_uc003ocb.1_Silent_p.Y537Y|TAP2_uc003ocd.2_Silent_p.Y537Y	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	537	ABC transporter.|Cytoplasmic (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						AGCAGTGTTCATACTGTGAGA	0.587													G	32798068	G	G	32798068	2	3	271	1	0	0	0	0	0	0	0	1	15548	224	8	4		4	TAP2	6	32798068	Silent	SNP	A	TCGA-76-6283-01A-11D-1845-08	25221453	32798068	138316999	46	19424											
TREML2	79865	broad.mit.edu	37	chr6	41166078	41166078	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaaaccttgccctccacgcGgtttttgtagcccttatagg	8	14	0	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr6:41166078G>A	uc010jxm.1	-	2	324	c.145C>T	c.(145-147)CGC>TGC	p.R49C		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid	49	Ig-like V-type.|Extracellular (Potential).				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCCTCCACGCGGTTTTTGTAG	0.547													A	41166078	A	A	41166078	3	1	271	1	0	0	0	0	1	0	0	0	16470	1116	39	2	836	2	TREML2	6	41166078	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	8368010	41166078	129948989	47	19425											
ABCC10	89845	broad.mit.edu	37	chr6	43417751	43417751	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gactccccggccaccctgcgCaaccagccccactccctgtt	7	22	0	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr6:43417751C>T	uc003ouy.1	+	22	4616	c.4401C>T	c.(4399-4401)CGC>CGT	p.R1467R	ABCC10_uc003ouz.1_Silent_p.R1439R|ABCC10_uc010jyo.1_Silent_p.R573R	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1467	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CCACCCTGCGCAACCAGCCCC	0.642													T	43417751	T	T	43417751	2	4	271	1	0	0	0	0	0	0	0	1	50	697	25	3		3	ABCC10	6	43417751	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	2251673	43417751	127697316	48	19426											
ZDHHC4	55146	broad.mit.edu	37	chr7	6628405	6628405	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgactgggcctggtgccagcGttgtccccttgtggcctggc	15	13	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr7:6628405G>A	uc003sqi.2	+	9	1257	c.899G>A	c.(898-900)CGT>CAT	p.R300H	ZDHHC4_uc003sql.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqh.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqj.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqk.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqm.2_Missense_Mutation_p.R300H|uc011jwy.1_5'Flank|C7orf26_uc003sqo.1_5'Flank|C7orf26_uc003sqp.1_5'Flank|C7orf26_uc003sqq.1_5'Flank	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	300						integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		TGGTGCCAGCGTTGTCCCCTT	0.577													A	6628405	A	A	6628405	3	1	271	1	0	0	0	0	1	0	0	0	17614	1145	40	1	921	1	ZDHHC4	7	6628405	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08		6628405	152510258	49	19427											
CALCR	799	broad.mit.edu	37	chr7	93108737	93108737	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtgcatccatcatcttctttCgtcctacgacgtaaagaaat	6	11	3	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr7:93108737C>T	uc003umv.1	-	4	449	c.188G>A	c.(187-189)CGA>CAA	p.R63Q	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.R45Q|CALCR_uc003umw.2_Missense_Mutation_p.R45Q	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	45	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CATCTTCTTTCGTCCTACGAC	0.403													T	93108737	T	T	93108737	3	4	271	1	0	0	0	0	1	0	0	0	2579	884	31	2	1386	2	CALCR	7	93108737	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	86480332	93108737	66029926	50	19428											
RBM28	55131	broad.mit.edu	37	chr7	127979698	127979698	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaaactcaccatttttccccTtttcctttgtcttgttcctc	3	14	2	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr7:127979698T>C	uc003vmp.2	-	2	381	c.266A>G	c.(265-267)AAG>AGG	p.K89R	RBM28_uc011koj.1_Intron|RBM28_uc011kok.1_Missense_Mutation_p.K36R	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	89					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						ATTTTTCCCCTTTTCCTTTGT	0.443													C	127979698	C	C	127979698	3	2	271	1	0	0	0	0	1	0	0	0	13128	1609	56	4	2085	4	RBM28	7	127979698	Missense_Mutation	SNP	T	TCGA-76-6283-01A-11D-1845-08	34870961	127979698	31158965	51	19429											
INTS10	55174	broad.mit.edu	37	chr8	19677962	19677962	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacggaacaatgcttcaacaCgttagaacgatcagaaatgt	8	9	2	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr8:19677962C>T	uc003wzj.2	+	4	505	c.374C>T	c.(373-375)ACG>ATG	p.T125M		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	125					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		TGCTTCAACACGTTAGAACGA	0.403													T	19677962	T	T	19677962	3	4	271	1	0	0	0	0	1	0	0	0	7776	536	19	1	388	1	INTS10	8	19677962	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08		19677962	126686060	52	19430											
DCAF4L2	138009	broad.mit.edu	37	chr8	88886278	88886278	+	Translation_Start_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtaccgcttctttacaagcaCgacttggcacggaagaactt	9	11	1	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr8:88886278C>T	uc003ydz.2	-	1	19	c.-78G>A	c.(-80--76)TCGTG>TCATG			NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C											ovary(1)	1						TTTACAAGCACGACTTGGCAC	0.577													T	88886278	T	T	88886278	1	4	271	1	0	0	0	0	0	0	0	0	4272	551	19	1		1	DCAF4L2	8	88886278	Translation_Start_Site	SNP	C	TCGA-76-6283-01A-11D-1845-08	69208316	88886278	57477744	53	19431											
SLC25A32	81034	broad.mit.edu	37	chr8	104417070	104417070	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	agctcttccttctgttttatAtgacttgatggcattgtaac	7	8	2	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr8:104417070A>T	uc003yll.2	-	3	628	c.325T>A	c.(325-327)TAT>AAT	p.Y109N	SLC25A32_uc011lhr.1_Intron	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	109	Solcar 1.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	TCTGTTTTATATGACTTGATG	0.353													T	104417070	T	T	104417070	3	4	271	1	0	0	0	0	1	0	0	0	14496	449	16	5	642	5	SLC25A32	8	104417070	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08	15530792	104417070	41946952	54	19432											
GPRIN2	9721	broad.mit.edu	37	chr10	46999114	46999114	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgaagccagcacgggcctcTggccccaaggcgcgacccag	13	16	1	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr10:46999114T>G	uc001jec.2	+	3	369	c.234T>G	c.(232-234)TCT>TCG	p.S78S	GPRIN2_uc010qfq.1_5'Flank	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	78											0						CACGGGCCTCTGGCCCCAAGG	0.706													G	46999114	G	G	46999114	2	3	271	1	0	0	0	0	0	0	0	1	6730	1567	55	5		5	GPRIN2	10	46999114	Silent	SNP	T	TCGA-76-6283-01A-11D-1845-08		46999114	88535633	55	19433											
PTEN	5728	broad.mit.edu	37	chr10	89624265	89624267	+	In_Frame_Del	DEL	AAG	-	-													gagatcgttagcagaaacaaAaggagatatcaagaggatgg							TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr10:89624265_89624267delAAG	uc001kfb.2	+	2	1070_1072	c.39_41delAAG	c.(37-42)AAAAGG>AAG	p.R15del	KILLIN_uc009xti.2_5'Flank	NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	15	Phosphatase tensin-type.		R -> S (in glioma).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(13)|p.0?(12)|p.R15I(4)|p.R15S(3)|p.R14G(2)|p.R14fs*29(1)|p.R15K(1)|p.R15fs*28(1)|p.I8_R14>LRLICIF(1)|p.R14fs*10(1)|p.R15fs*9(1)|p.K13del(1)|p.N12fs*6(1)|p.R14_D22del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GCAGAAACAAAAGGAGATATCAA	0.488		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89624267	-	-	89624265	7	5	271	1	0	1	0	1	0	0	0	0	12738	11	1	0	41	0	PTEN	10	89624265	In_Frame_Del	DEL	AAG	TCGA-76-6283-01A-11D-1845-08	42625151	89624265	45910482	56	19434											
CPT1A	1374	broad.mit.edu	37	chr11	68549243	68549243	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaggtaaggacggtacctgtCgtaacatcggccgtgtagta	13	8	0	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr11:68549243C>T	uc001oog.3	-	11	1518	c.1348G>A	c.(1348-1350)GAC>AAC	p.D450N	CPT1A_uc001oof.3_Missense_Mutation_p.D450N|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	450	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CGGTACCTGTCGTAACATCGG	0.473													T	68549243	T	T	68549243	3	4	271	1	0	0	0	0	1	0	0	0	3831	884	31	2	1049	2	CPT1A	11	68549243	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08		68549243	66457273	57	19435											
FAT3	120114	broad.mit.edu	37	chr11	92539549	92539549	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgcatatacagcattacttCctgaagacattccatcaaat	4	10	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr11:92539549C>T	uc001pdj.3	+	11	9132	c.9115C>T	c.(9115-9117)CCT>TCT	p.P3039S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3039	Cadherin 28.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGCATTACTTCCTGAAGACAT	0.358										TCGA Ovarian(4;0.039)			T	92539549	T	T	92539549	3	4	271	1	0	0	0	0	1	0	0	0	5691	855	30	3	9157	3	FAT3	11	92539549	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	23990306	92539549	42466967	58	19436											
CD163L1	283316	broad.mit.edu	37	chr12	7559424	7559424	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agcggttagttccacctacaAgccttagttcaagatcacta	7	11	2	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr12:7559424A>G	uc001qsy.2	-	5	817	c.791T>C	c.(790-792)CTT>CCT	p.L264P	CD163L1_uc010sge.1_Missense_Mutation_p.L274P	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	264	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TCCACCTACAAGCCTTAGTTC	0.448													G	7559424	G	G	7559424	3	3	271	1	0	0	0	0	1	0	0	0	2968	72	3	4	3630	4	CD163L1	12	7559424	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08		7559424	126292471	59	19437											
AICDA	57379	broad.mit.edu	37	chr12	8759510	8759510	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaaggatgtagcactgtcaCgcctcttcactacgtagcac	8	12	3	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr12:8759510C>T	uc001qur.2	-	2	186	c.107G>A	c.(106-108)CGT>CAT	p.R36H	AICDA_uc001qup.1_Missense_Mutation_p.R31H|AICDA_uc001quq.1_Missense_Mutation_p.R31H|AICDA_uc009zgd.1_RNA	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	36					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					AGCACTGTCACGCCTCTTCAC	0.463									Immune_Deficiency_with_Hyper-IgM				T	8759510	T	T	8759510	3	4	271	1	0	0	0	0	1	0	0	0	422	536	19	1	505	1	AICDA	12	8759510	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	1200086	8759510	125092385	60	19438											
SENP1	29843	broad.mit.edu	37	chr12	48465464	48465464	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtttacctgggagttggagtCtgggaatctttcactttcag	12	7	4	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr12:48465464C>T	uc001rqx.2	-	9	1427	c.981G>A	c.(979-981)CAG>CAA	p.Q327Q	SENP1_uc001rqw.2_Silent_p.Q327Q|SENP1_uc001rqy.2_Silent_p.Q128Q|SENP1_uc001rqz.2_Silent_p.Q128Q|SENP1_uc009zkx.2_Silent_p.Q327Q	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	327					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				GAGTTGGAGTCTGGGAATCTT	0.249													T	48465464	T	T	48465464	2	4	271	1	0	0	0	0	0	0	0	1	14046	912	32	3		3	SENP1	12	48465464	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	39705954	48465464	85386431	61	19439											
DGKA	1606	broad.mit.edu	37	chr12	56336026	56336026	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtactggaaatgatctggctCgatgcctaagatggggagga	15	6	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr12:56336026C>T	uc001sij.2	+	17	1669	c.1405C>T	c.(1405-1407)CGA>TGA	p.R469*	DGKA_uc001sih.1_Nonsense_Mutation_p.R357*|DGKA_uc001sii.1_Nonsense_Mutation_p.R327*|DGKA_uc009zod.1_Nonsense_Mutation_p.R388*|DGKA_uc001sik.2_Nonsense_Mutation_p.R469*|DGKA_uc001sil.2_Nonsense_Mutation_p.R469*|DGKA_uc001sim.2_Nonsense_Mutation_p.R469*|DGKA_uc001sin.2_Nonsense_Mutation_p.R469*|DGKA_uc009zof.2_Nonsense_Mutation_p.R115*|DGKA_uc001sio.2_Nonsense_Mutation_p.R211*	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	469	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	TGATCTGGCTCGATGCCTAAG	0.498													T	56336026	T	T	56336026	4	4	271	1	0	0	0	0	0	1	0	0	4465	876	31	2	1467	2	DGKA	12	56336026	Nonsense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	7870562	56336026	77515869	62	19440											
SSH1	54434	broad.mit.edu	37	chr12	109194640	109194640	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgtagactcggatgttatgaTatgcaaataagccaggaaaa	10	6	0	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr12:109194640T>C	uc001tnm.2	-	12	1151	c.1064A>G	c.(1063-1065)TAT>TGT	p.Y355C	SSH1_uc001tnl.2_Missense_Mutation_p.Y43C|SSH1_uc010sxg.1_Missense_Mutation_p.Y366C|SSH1_uc001tnn.3_Missense_Mutation_p.Y355C	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	355	Tyrosine-protein phosphatase.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						GATGTTATGATATGCAAATAA	0.363													C	109194640	C	C	109194640	3	2	271	1	0	0	0	0	1	0	0	0	15183	1406	49	4	2287	4	SSH1	12	109194640	Missense_Mutation	SNP	T	TCGA-76-6283-01A-11D-1845-08	52858614	109194640	24657255	63	19441											
VSIG10	54621	broad.mit.edu	37	chr12	118509166	118509166	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gacccagggagtccttacctTtccagcagaacacagggcta	10	13	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr12:118509166T>G	uc001tws.2	-	6	1662	c.1328A>C	c.(1327-1329)AAA>ACA	p.K443T		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	443	Cytoplasmic (Potential).					integral to membrane					0						GTCCTTACCTTTCCAGCAGAA	0.532													G	118509166	G	G	118509166	3	3	271	1	0	0	0	0	1	0	0	0	17220	1841	64	5	310	5	VSIG10	12	118509166	Missense_Mutation	SNP	T	TCGA-76-6283-01A-11D-1845-08	9314526	118509166	15342729	64	19442											
RB1	5925	broad.mit.edu	37	chr13	48941638	48941641	+	Frame_Shift_Del	DEL	TCTT	-	-													ttttctttcaaggttgaaaaTctttctaaacgatacgaaga							TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr13:48941638_48941641delTCTT	uc001vcb.2	+	10	1114_1117	c.948_951delTCTT	c.(946-951)AATCTTfs	p.N316fs	RB1_uc010act.1_Frame_Shift_Del_p.N17fs	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	316_317					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGGTTGAAAATCTTTCTAAACGAT	0.299		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			-	48941641	-	-	48941638	7	5	271	1	0	1	0	1	0	0	0	0	13098	1432	50	0	986	0	RB1	13	48941638	Frame_Shift_Del	DEL	TCTT	TCGA-76-6283-01A-11D-1845-08		48941638	66228240	65	19443											
PIBF1	10464	broad.mit.edu	37	chr13	73372127	73372127	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaatatcctagcagaagaatTaagtacaaacaaaaaccaac	5	8	0	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr13:73372127T>A	uc001vjc.2	+	5	940	c.635T>A	c.(634-636)TTA>TAA	p.L212*	PIBF1_uc001vja.1_Nonsense_Mutation_p.L212*|PIBF1_uc010aeo.1_RNA|PIBF1_uc001vjb.2_Nonsense_Mutation_p.L212*|PIBF1_uc010aep.2_Intron	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	212						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		GCAGAAGAATTAAGTACAAAC	0.373													A	73372127	A	A	73372127	4	1	271	1	0	0	0	0	0	1	0	0	11879	1764	61	5	649	5	PIBF1	13	73372127	Nonsense_Mutation	SNP	T	TCGA-76-6283-01A-11D-1845-08	24430489	73372127	41797751	66	19444											
MIA2	117153	broad.mit.edu	37	chr14	39722420	39722420	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gcaataattttacctattttGctaaatataagagtggctac	6	6	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr14:39722420G>T	uc001wux.2	+	6	2126	c.1932G>T	c.(1930-1932)TTG>TTT	p.L644F		NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	Error:Variant_position_missing_in_Q96PC5_after_alignment						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		TACCTATTTTGCTAAATATAA	0.289													T	39722420	T	T	39722420	3	4	271	1	0	0	0	0	1	0	0	0	9564	1310	46	5	1954	5	MIA2	14	39722420	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08		39722420	67627120	67	19445											
FLVCR2	55640	broad.mit.edu	37	chr14	76107379	76107379	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaatcagaaggcatctcctcCggcctcctcaacatatctgc	7	15	4	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr14:76107379C>T	uc001xrs.2	+	7	1693	c.1317C>T	c.(1315-1317)TCC>TCT	p.S439S	FLVCR2_uc010tvd.1_Silent_p.S234S	NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	439	Helical; (Potential).			S -> F (in Ref. 3; BAA91126).	transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		GCATCTCCTCCGGCCTCCTCA	0.502													T	76107379	T	T	76107379	2	4	271	1	0	0	0	0	0	0	0	1	5946	639	23	2		2	FLVCR2	14	76107379	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	36384959	76107379	31242161	68	19446											
SPTBN5	51332	broad.mit.edu	37	chr15	42148626	42148626	+	Frame_Shift_Del	DEL	A	-	-													tcctgagcctgctgcagcagAagccgcctccgcgccgcctc							TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr15:42148626delA	uc001zos.2	-	53	9207	c.8874delT	c.(8872-8874)CTTfs	p.L2958fs		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2993	Spectrin 26.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCTGCAGCAGAAGCCGCCTCC	0.697													-	42148626	-	-	42148626	7	5	271	1	0	1	0	1	0	0	0	0	15121	233	9	0	2109	0	SPTBN5	15	42148626	Frame_Shift_Del	DEL	A	TCGA-76-6283-01A-11D-1845-08		42148626	60382766	69	19447											
ZSCAN29	146050	broad.mit.edu	37	chr15	43661801	43661801	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	cctcccttctcaccgaagatCtaggtcttccaggctctctt	6	16	4	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr15:43661801C>G	uc001zrk.1	-	1	458	c.311G>C	c.(310-312)AGA>ACA	p.R104T	ZSCAN29_uc001zrj.1_5'Flank|ZSCAN29_uc010bdf.1_Missense_Mutation_p.R103T|ZSCAN29_uc001zrl.1_RNA|ZSCAN29_uc010bdg.1_Missense_Mutation_p.R103T|ZSCAN29_uc001zrm.2_Missense_Mutation_p.R103T|TUBGCP4_uc001zrn.2_5'Flank|TUBGCP4_uc001zro.2_5'Flank	NM_152455	NP_689668	Q8IWY8	ZSC29_HUMAN	zinc finger protein 690	104					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		CACCGAAGATCTAGGTCTTCC	0.468													G	43661801	G	G	43661801	3	3	271	1	0	0	0	0	1	0	0	0	18233	913	32	5	2267	5	ZSCAN29	15	43661801	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	1513175	43661801	58869591	70	19448											
ONECUT1	3175	broad.mit.edu	37	chr15	53081863	53081863	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccaggctgtgctcaggggcCcggtggtggtggtggtaatc	19	9	1	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr15:53081863C>T	uc002aci.1	-	1	347	c.219G>A	c.(217-219)CGG>CGA	p.R73R		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	73					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		GCTCAGGGGCCCGGTGGTGGT	0.711													T	53081863	T	T	53081863	2	4	271	1	0	0	0	0	0	0	0	1	10868	610	22	3		3	ONECUT1	15	53081863	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	9420062	53081863	49449529	71	19449											
TCF12	6938	broad.mit.edu	37	chr15	57565229	57565244	+	Frame_Shift_Del	DEL	AGTACTAATGAAGATG	-	-													ttgttactttattttctagcAgtactaatgaagatgaggat							TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr15:57565229_57565244delAGTACTAATGAAGATG	uc002aec.2	+	18	1959_1974	c.1675_1690delAGTACTAATGAAGATG	c.(1675-1692)AGTACTAATGAAGATGAGfs	p.S559fs	TCF12_uc010ugm.1_Frame_Shift_Del_p.S611fs|TCF12_uc010ugn.1_Frame_Shift_Del_p.S579fs|TCF12_uc002aea.2_Frame_Shift_Del_p.S583fs|TCF12_uc010bfs.2_5'UTR|TCF12_uc002aeb.2_Frame_Shift_Del_p.S583fs|TCF12_uc002aed.2_Frame_Shift_Del_p.S559fs|TCF12_uc002aee.2_Frame_Shift_Del_p.S389fs|TCF12_uc010bft.2_Frame_Shift_Del_p.S413fs|TCF12_uc010ugo.1_Frame_Shift_Del_p.S323fs|TCF12_uc010ugp.1_Splice_Site_p.S216_splice|TCF12_uc010ugq.1_Frame_Shift_Del_p.S193fs|TCF12_uc010ugr.1_Frame_Shift_Del_p.S172fs	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	559_564					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ATTTTCTAGCAGTACTAATGAAGATGAGGATTTGAA	0.384			T	TEC	extraskeletal myxoid chondrosarcoma								-	57565244	-	-	57565229	7	5	271	1	0	1	0	1	0	0	0	0	15684	202	7	0	1890	0	TCF12	15	57565229	Frame_Shift_Del	DEL	AGTACTAATGAAGATG	TCGA-76-6283-01A-11D-1845-08	4483366	57565229	44966163	72	19450											
ZNF592	9640	broad.mit.edu	37	chr15	85326217	85326217	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctcagatctgcctccagatcCccacaactgtgggaaatttg	8	13	2	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr15:85326217C>A	uc002bld.2	+	4	647	c.311C>A	c.(310-312)CCC>CAC	p.P104H	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	104					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCTCCAGATCCCCACAACTGT	0.512													A	85326217	A	A	85326217	3	1	271	1	0	0	0	0	1	0	0	0	18019	623	22	5	313	5	ZNF592	15	85326217	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	27760988	85326217	17205175	73	19451											
SLC28A1	9154	broad.mit.edu	37	chr15	85478601	85478601	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agccttcttgatgggtgtggCgtgggaggactgcccagtgg	18	8	1	1	rs116070802	by1000genomes	TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr15:85478601C>T	uc002blg.2	+	15	1635	c.1433C>T	c.(1432-1434)GCG>GTG	p.A478V	SLC28A1_uc010bnb.2_Missense_Mutation_p.A478V|SLC28A1_uc010upe.1_Intron|SLC28A1_uc010upf.1_Missense_Mutation_p.A478V|SLC28A1_uc010upg.1_Missense_Mutation_p.A478V	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	478					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ATGGGTGTGGCGTGGGAGGAC	0.597													T	85478601	T	T	85478601	3	4	271	1	0	0	0	0	1	0	0	0	14531	768	27	1	1554	1	SLC28A1	15	85478601	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	152384	85478601	17052791	74	19452											
CRTC3	64784	broad.mit.edu	37	chr15	91184403	91184403	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaagcccgtattccaactgCgggagtctcccgaacaccat	8	16	1	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr15:91184403C>T	uc002bpp.2	+	14	1729	c.1623C>T	c.(1621-1623)TGC>TGT	p.C541C	CRTC3_uc002bpo.2_Silent_p.C541C	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	541					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			ATTCCAACTGCGGGAGTCTCC	0.507			T	MAML2	salivary gland mucoepidermoid								T	91184403	T	T	91184403	2	4	271	1	0	0	0	0	0	0	0	1	3901	776	27	1		1	CRTC3	15	91184403	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	5705802	91184403	11346989	75	19453											
WDR90	197335	broad.mit.edu	37	chr16	711897	711897	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcatactttgccaggtgcgtCgagagccagtcccagaggca	12	12	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr16:711897C>T	uc002cii.1	+	32	3925	c.3871C>T	c.(3871-3873)CGA>TGA	p.R1291*	WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Nonsense_Mutation_p.R818*|WDR90_uc002cil.1_RNA|WDR90_uc002cim.1_Nonsense_Mutation_p.R465*|WDR90_uc002cin.1_5'UTR	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1291										ovary(1)	1		Hepatocellular(780;0.0218)				CCAGGTGCGTCGAGAGCCAGT	0.637													T	711897	T	T	711897	4	4	271	1	0	0	0	0	0	1	0	0	17334	876	31	2	3997	2	WDR90	16	711897	Nonsense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08		711897	89642856	76	19454											
MLST8	64223	broad.mit.edu	37	chr16	2256621	2256621	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacggccgctggatgtacaCgggcggcgaggactgcacag	17	11	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr16:2256621C>T	uc002coz.2	+	4	424	c.305C>T	c.(304-306)ACG>ATG	p.T102M	MLST8_uc002coy.2_Missense_Mutation_p.T102M|MLST8_uc002cpa.2_Translation_Start_Site|MLST8_uc002cpb.2_Missense_Mutation_p.T101M|MLST8_uc010uvx.1_Missense_Mutation_p.T36M|MLST8_uc002cpc.2_Missense_Mutation_p.T102M|MLST8_uc002cpd.2_Missense_Mutation_p.T36M|MLST8_uc002cpe.2_Missense_Mutation_p.T102M|MLST8_uc010uvy.1_Missense_Mutation_p.T102M|MLST8_uc002cpg.2_Missense_Mutation_p.T121M|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_Missense_Mutation_p.T102M	NM_022372	NP_071767	Q9BVC4	LST8_HUMAN	G protein beta subunit-like	102	WD 3.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0						TGGATGTACACGGGCGGCGAG	0.627													T	2256621	T	T	2256621	3	4	271	1	0	0	0	0	1	0	0	0	9634	536	19	1	315	1	MLST8	16	2256621	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	1544724	2256621	88098132	77	19455											
CCNF	899	broad.mit.edu	37	chr16	2506722	2506722	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctggacccaaacccctggtcCgcaccagccgggagccaggg	13	17	0	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr16:2506722C>T	uc002cqd.1	+	17	2150	c.2062C>T	c.(2062-2064)CGC>TGC	p.R688C	CCNF_uc002cqe.1_Missense_Mutation_p.R380C	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	688	PEST.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				ACCCCTGGTCCGCACCAGCCG	0.662													T	2506722	T	T	2506722	3	4	271	1	0	0	0	0	1	0	0	0	2922	652	23	2	2128	2	CCNF	16	2506722	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	250101	2506722	87848031	78	19456											
GOT2	2806	broad.mit.edu	37	chr16	58752174	58752174	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggattgtgggcgcaggcatGcagaagaagaacactctgct	15	8	1	3			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr16:58752174G>A	uc002eof.1	-	6	742	c.628C>T	c.(628-630)CAT>TAT	p.H210Y	GOT2_uc010vim.1_Missense_Mutation_p.H167Y	NM_002080	NP_002071	P00505	AATM_HUMAN	aspartate aminotransferase 2 precursor	210					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GCGCAGGCATGCAGAAGAAGA	0.498													A	58752174	A	A	58752174	3	1	271	1	0	0	0	0	1	0	0	0	6581	1319	46	3	684	3	GOT2	16	58752174	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	56245452	58752174	31602579	79	19457											
CNTNAP4	85445	broad.mit.edu	37	chr16	76486640	76486640	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gtcgaatctctaccagccagGaaaattacccagtgacatca	7	12	2	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr16:76486640G>A	uc002feu.1	+	10	1692	c.1307G>A	c.(1306-1308)GGA>GAA	p.G436E	CNTNAP4_uc002fev.1_Missense_Mutation_p.G300E|CNTNAP4_uc010chb.1_Missense_Mutation_p.G363E|CNTNAP4_uc002fex.1_Missense_Mutation_p.G439E|CNTNAP4_uc002few.2_Missense_Mutation_p.G411E	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	436	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TACCAGCCAGGAAAATTACCC	0.428													A	76486640	A	A	76486640	3	1	271	1	0	0	0	0	1	0	0	0	3649	1174	41	3	1350	3	CNTNAP4	16	76486640	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	17734466	76486640	13868113	80	19458											
ZC3H18	124245	broad.mit.edu	37	chr16	88688687	88688687	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgagtggaaggacccttggCgccgatccaagtctcccaag	12	12	1	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr16:88688687C>T	uc002fky.2	+	9	1758	c.1558C>T	c.(1558-1560)CGC>TGC	p.R520C	ZC3H18_uc010voz.1_Missense_Mutation_p.R544C|ZC3H18_uc010chw.2_RNA	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	520						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		GGACCCTTGGCGCCGATCCAA	0.602													T	88688687	T	T	88688687	3	4	271	1	0	0	0	0	1	0	0	0	17565	768	27	1	1588	1	ZC3H18	16	88688687	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	12202047	88688687	1666066	81	19459											
PITPNM3	83394	broad.mit.edu	37	chr17	6376097	6376097	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgtgaggcagaggggtctgCgcaatggaagaagctgtaga	17	7	1	4			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr17:6376097C>T	uc002gdd.3	-	11	1460	c.1309G>A	c.(1309-1311)GCA>ACA	p.A437T	PITPNM3_uc010cln.2_Missense_Mutation_p.A401T|PITPNM3_uc010clm.2_5'UTR|PITPNM3_uc002gdc.3_Missense_Mutation_p.A28T	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	437	DDHD.				phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		GAGGGGTCTGCGCAATGGAAG	0.632													T	6376097	T	T	6376097	3	4	271	1	0	0	0	0	1	0	0	0	11952	768	27	1	1655	1	PITPNM3	17	6376097	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08		6376097	74819113	82	19460											
TP53	7157	broad.mit.edu	37	chr17	7578457	7578457	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttgtagatggccatggcgCggacgcgggtgccgggcggg	21	10	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr17:7578457C>T	uc002gim.2	-	5	667	c.473G>A	c.(472-474)CGC>CAC	p.R158H	TP53_uc002gig.1_Missense_Mutation_p.R158H|TP53_uc002gih.2_Missense_Mutation_p.R158H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26H|TP53_uc010cng.1_Missense_Mutation_p.R26H|TP53_uc002gii.1_Missense_Mutation_p.R26H|TP53_uc010cnh.1_Missense_Mutation_p.R158H|TP53_uc010cni.1_Missense_Mutation_p.R158H|TP53_uc002gij.2_Missense_Mutation_p.R158H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65H|TP53_uc002gio.2_Missense_Mutation_p.R26H|TP53_uc010vug.1_Missense_Mutation_p.R119H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578457	T	T	7578457	3	4	271	1	0	0	0	0	1	0	0	0	16378	768	27	1	825	1	TP53	17	7578457	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	1202360	7578457	73616753	83	19461											
MED13	9969	broad.mit.edu	37	chr17	60072508	60072512	+	Splice_Site	DEL	CTTAC	-	-													tttggtgtactgtgatttctCttaccttgtgtttttttcca							TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr17:60072508_60072512delCTTAC	uc002izo.2	-	10	2258	c.2181_splice	c.e10+1	p.K727_splice		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TGTGATTTCTCTTACCTTGTGTTTT	0.346													-	60072512	-	-	60072508	8	5	271	1	0	1	0	1	0	0	1	0	9430	928	32	0		0	MED13	17	60072508	Splice_Site	DEL	CTTAC	TCGA-76-6283-01A-11D-1845-08	52494051	60072508	21122702	84	19462											
FSCN2	25794	broad.mit.edu	37	chr17	79503762	79503762	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccagctggacaccaaccgctCcgtctacgacgtcttccacc	7	19	2	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr17:79503762C>T	uc010wup.1	+	4	1361	c.1220C>T	c.(1219-1221)TCC>TTC	p.S407F	FSCN2_uc010wuo.1_Missense_Mutation_p.S431F	NM_012418	NP_036550	O14926	FSCN2_HUMAN	fascin 2 isoform 1	407					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging				0	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			ACCAACCGCTCCGTCTACGAC	0.701													T	79503762	T	T	79503762	3	4	271	1	0	0	0	0	1	0	0	0	6068	855	30	3	1145	3	FSCN2	17	79503762	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	19431254	79503762	1691448	85	19463											
LAMA3	3909	broad.mit.edu	37	chr18	21441699	21441699	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcagcaacagtatggtggcGgatctccaggagctgcccgc	15	12	1	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr18:21441699G>A	uc002kuq.2	+	35	4598	c.4512G>A	c.(4510-4512)GCG>GCA	p.A1504A	LAMA3_uc002kur.2_Silent_p.A1504A	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1504	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTATGGTGGCGGATCTCCAGG	0.587													A	21441699	A	A	21441699	2	1	271	1	0	0	0	0	0	0	0	1	8607	1103	39	2		2	LAMA3	18	21441699	Silent	SNP	G	TCGA-76-6283-01A-11D-1845-08		21441699	56635549	86	19464											
DPP9	91039	broad.mit.edu	37	chr19	4704202	4704202	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgttgctggcctggaagaGgaagaggccactctcgctgt	15	10	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr19:4704202G>A	uc002mba.2	-	6	799	c.541C>T	c.(541-543)CTC>TTC	p.L181F	DPP9_uc002mbb.2_Missense_Mutation_p.L181F|DPP9_uc002mbc.2_Missense_Mutation_p.L181F	NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	152					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GCCTGGAAGAGGAAGAGGCCA	0.657													A	4704202	A	A	4704202	3	1	271	1	0	0	0	0	1	0	0	0	4733	1000	35	3	2205	3	DPP9	19	4704202	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08		4704202	54424781	87	19465											
VAV1	7409	broad.mit.edu	37	chr19	6828671	6828671	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacgaggtcaagcgagacaaCgagacactgcgacagatcac	11	11	2	3	rs61750002		TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr19:6828671C>T	uc002mfu.1	+	12	1228	c.1131C>T	c.(1129-1131)AAC>AAT	p.N377N	VAV1_uc010xjh.1_Silent_p.N345N|VAV1_uc010dva.1_Silent_p.N377N|VAV1_uc002mfv.1_Silent_p.N322N	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	377					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						AGCGAGACAACGAGACACTGC	0.637													T	6828671	T	T	6828671	2	4	271	1	0	0	0	0	0	0	0	1	17128	535	19	1		1	VAV1	19	6828671	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	2124469	6828671	52300312	88	19466											
IL12RB1	3594	broad.mit.edu	37	chr19	18174730	18174730	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccagacacccctcagccacGctgtgtctgctcgcacctgc	8	19	2	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr19:18174730G>A	uc002nhw.1	-	13	1638	c.1574C>T	c.(1573-1575)GCG>GTG	p.A525V	IL12RB1_uc010xqb.1_Missense_Mutation_p.A525V|IL12RB1_uc002nhx.1_Missense_Mutation_p.A565V	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	525	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						CCTCAGCCACGCTGTGTCTGC	0.632													A	18174730	A	A	18174730	3	1	271	1	0	0	0	0	1	0	0	0	7626	1087	38	1	434	1	IL12RB1	19	18174730	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	11346059	18174730	40954253	89	19467											
IGFL3	388555	broad.mit.edu	37	chr19	46627409	46627409	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cacagtcctgagccaacaggAgcgtctgggggcagacattg	14	11	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr19:46627409A>T	uc002pea.1	-	3	109	c.84T>A	c.(82-84)GCT>GCA	p.A28A		NM_207393	NP_997276	Q6UXB1	IGFL3_HUMAN	IGF-like family member 3 precursor	28						extracellular region	protein binding				0		Ovarian(192;0.0175)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00473)|GBM - Glioblastoma multiforme(486;0.0149)|Epithelial(262;0.239)		AGCCAACAGGAGCGTCTGGGG	0.507													T	46627409	T	T	46627409	2	4	271	1	0	0	0	0	0	0	0	1	7588	291	11	5		5	IGFL3	19	46627409	Silent	SNP	A	TCGA-76-6283-01A-11D-1845-08	28452679	46627409	12501574	90	19468											
SULT2B1	6820	broad.mit.edu	37	chr19	49090651	49090651	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctcatgagctcccatcttcCcatccagatcttcaccaagg	5	17	4	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr19:49090651C>T	uc002pjl.2	+	3	461	c.380C>T	c.(379-381)CCC>CTC	p.P127L	SULT2B1_uc002pjm.2_Missense_Mutation_p.P112L	NM_177973	NP_814444	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	127					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			skin(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		TCCCATCTTCCCATCCAGATC	0.612													T	49090651	T	T	49090651	3	4	271	1	0	0	0	0	1	0	0	0	15379	623	22	3	416	3	SULT2B1	19	49090651	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	2463242	49090651	10038332	91	19469											
KLK9	284366	broad.mit.edu	37	chr19	51509764	51509764	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agatgagacactgcatgcctGgggagacacaggtctggctg	15	9	1	3			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr19:51509764G>A	uc002pux.1	-	3	503	c.416C>T	c.(415-417)CCA>CTA	p.P139L	KLK9_uc002puw.1_RNA|KLK9_uc010eol.1_Missense_Mutation_p.P110L|KLK9_uc002puv.1_5'Flank	NM_012315	NP_036447	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9 precursor	139	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		CTGCATGCCTGGGGAGACACA	0.512													A	51509764	A	A	51509764	3	1	271	1	0	0	0	0	1	0	0	0	8411	1348	47	3	348	3	KLK9	19	51509764	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	2419113	51509764	7619219	92	19470											
SIGLEC8	27181	broad.mit.edu	37	chr19	51957534	51957534	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctgtatcccccacgcccgctGctggccttgccgatttcttc	8	18	1	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr19:51957534G>T	uc002pwt.2	-	6	1251	c.1184C>A	c.(1183-1185)GCA>GAA	p.A395E	SIGLEC8_uc010yda.1_Missense_Mutation_p.A286E|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Missense_Mutation_p.A302E	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	395	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CACGCCCGCTGCTGGCCTTGC	0.602													T	51957534	T	T	51957534	3	4	271	1	0	0	0	0	1	0	0	0	14314	1319	46	5	323	5	SIGLEC8	19	51957534	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	447770	51957534	7171449	93	19471											
ZNF845	91664	broad.mit.edu	37	chr19	53854579	53854579	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agagaaaaatctttccaatgTaatgagagtggcaaagcctt	9	6	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr19:53854579T>C	uc010ydv.1	+	4	768	c.651T>C	c.(649-651)TGT>TGC	p.C217C	ZNF845_uc010ydw.1_Silent_p.C217C	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	217	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTTCCAATGTAATGAGAGTG	0.353													C	53854579	C	C	53854579	2	2	271	1	0	0	0	0	0	0	0	1	18188	1644	57	4		4	ZNF845	19	53854579	Silent	SNP	T	TCGA-76-6283-01A-11D-1845-08	1897045	53854579	5274404	94	19472											
NLRP9	338321	broad.mit.edu	37	chr19	56241342	56241342	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcaaagctcccgccagtagaCgagcttctcattgtaactat	8	12	1	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr19:56241342C>T	uc002qly.2	-	3	1877	c.1849G>A	c.(1849-1851)GTC>ATC	p.V617I		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	617						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CGCCAGTAGACGAGCTTCTCA	0.418													T	56241342	T	T	56241342	3	4	271	1	0	0	0	0	1	0	0	0	10484	536	19	1	1154	1	NLRP9	19	56241342	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	2386763	56241342	2887641	95	19473											
TSHZ2	128553	broad.mit.edu	37	chr20	51870661	51870661	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccgatgccgacagtgcagcGcggcctatgacaccctagtc	11	15	0	1	rs141167641	by1000genomes	TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr20:51870661G>A	uc002xwo.2	+	2	1620	c.664G>A	c.(664-666)GCG>ACG	p.A222T		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	222	C2H2-type 1.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A222T(1)		ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			ACAGTGCAGCGCGGCCTATGA	0.562													A	51870661	A	A	51870661	3	1	271	1	0	0	0	0	1	0	0	0	16621	1087	38	1	670	1	TSHZ2	20	51870661	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08		51870661	11154859	96	19474											
PCK1	5105	broad.mit.edu	37	chr20	56137157	56137157	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcactgaccccagggatgtGgccaggatcgaaagcaagac	12	12	1	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr20:56137157G>A	uc002xyn.3	+	3	418	c.255G>A	c.(253-255)GTG>GTA	p.V85V	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	85					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCAGGGATGTGGCCAGGATCG	0.572													A	56137157	A	A	56137157	2	1	271	1	0	0	0	0	0	0	0	1	11581	1335	47	3		3	PCK1	20	56137157	Silent	SNP	G	TCGA-76-6283-01A-11D-1845-08	4266496	56137157	6888363	97	19475											
SYCP2	10388	broad.mit.edu	37	chr20	58467201	58467201	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatttcttcctatatatcagCgattcttcaattgtcttatt	3	8	5	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr20:58467201C>T	uc002yaz.2	-	23	2347	c.2208G>A	c.(2206-2208)TCG>TCA	p.S736S		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	736					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TATATATCAGCGATTCTTCAA	0.348													T	58467201	T	T	58467201	2	4	271	1	0	0	0	0	0	0	0	1	15429	755	27	1		1	SYCP2	20	58467201	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	2330044	58467201	4558319	98	19476											
KRTAP26-1	388818	broad.mit.edu	37	chr21	31692021	31692021	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acatacctctgtggtctacaGgatactggaaggcaggaact	11	9	2	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr21:31692021G>A	uc002ynw.2	-	1	587	c.333C>T	c.(331-333)TCC>TCT	p.S111S		NM_203405	NP_981950	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	111						intermediate filament				ovary(1)	1						GTGGTCTACAGGATACTGGAA	0.547													A	31692021	A	A	31692021	2	1	271	1	0	0	0	0	0	0	0	1	8543	987	35	3		3	KRTAP26-1	21	31692021	Silent	SNP	G	TCGA-76-6283-01A-11D-1845-08		31692021	16437874	99	19477											
BPIL2	254240	broad.mit.edu	37	chr22	32828374	32828374	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttacgaagtccatggaaaCgatggtttcaactgtggagt	11	7	1	0			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chr22:32828374C>T	uc003amn.2	-	10	1135	c.1135G>A	c.(1135-1137)GTT>ATT	p.V379I	BPIL2_uc010gwo.2_Intron|BPIL2_uc011amb.1_Missense_Mutation_p.V103I	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	379						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						TCCATGGAAACGATGGTTTCA	0.512													T	32828374	T	T	32828374	3	4	271	1	0	0	0	0	1	0	0	0	1492	536	19	1	412	1	BPIL2	22	32828374	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08		32828374	18476192	100	19478											
KAL1	3730	broad.mit.edu	37	chrX	8555862	8555862	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgtctgccagtgagtggcGtcatcttcgctaggatggat	13	9	3	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:8555862G>A	uc004csf.2	-	5	849	c.699C>T	c.(697-699)GAC>GAT	p.D233D		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	233	Fibronectin type-III 1.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4						AGTGAGTGGCGTCATCTTCGC	0.423													A	8555862	A	A	8555862	2	1	271	1	0	0	0	0	0	0	0	1	7974	1136	40	1		1	KAL1	23	8555862	Silent	SNP	G	TCGA-76-6283-01A-11D-1845-08		8555862	146714698	101	19479											
BEND2	139105	broad.mit.edu	37	chrX	18238990	18238990	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtggtaactgcgtacactcGttgtccgaggcacaatgagg	13	9	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:18238990G>A	uc004cyj.3	-	1	35	c.-119C>T	c.(-121--117)AACGA>AATGA		BEND2_uc010nfb.2_Translation_Start_Site	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2											ovary(3)|kidney(1)|central_nervous_system(1)	5						GCGTACACTCGTTGTCCGAGG	0.647													A	18238990	A	A	18238990	1	1	271	1	0	0	0	0	0	0	0	0	1398	1160	40	1		1	BEND2	23	18238990	Translation_Start_Site	SNP	G	TCGA-76-6283-01A-11D-1845-08	9683128	18238990	137031570	102	19480											
ARHGEF9	23229	broad.mit.edu	37	chrX	62875413	62875413	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	taccattttcctctcttctcTgaaagccctgagccagcgta	6	14	2	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:62875413T>C	uc004dvl.2	-	8	2100	c.1261A>G	c.(1261-1263)AGA>GGA	p.R421G	ARHGEF9_uc004dvj.1_Missense_Mutation_p.R310G|ARHGEF9_uc004dvk.1_Missense_Mutation_p.R239G|ARHGEF9_uc011mos.1_Missense_Mutation_p.R400G|ARHGEF9_uc004dvm.1_Missense_Mutation_p.R400G|ARHGEF9_uc011mot.1_Missense_Mutation_p.R368G|ARHGEF9_uc004dvn.2_Missense_Mutation_p.R428G	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	421	PH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						CTCTCTTCTCTGAAAGCCCTG	0.413													C	62875413	C	C	62875413	3	2	271	1	0	0	0	0	1	0	0	0	912	1588	55	4	301	4	ARHGEF9	23	62875413	Missense_Mutation	SNP	T	TCGA-76-6283-01A-11D-1845-08	44636423	62875413	92395147	103	19481											
LAS1L	81887	broad.mit.edu	37	chrX	64749656	64749656	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctcttgatcctcttcctctAtcccttccctgaactcctcc	2	20	3	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:64749656A>T	uc004dwa.1	-	5	689	c.617T>A	c.(616-618)ATA>AAA	p.I206K	LAS1L_uc004dwc.1_Missense_Mutation_p.I206K|LAS1L_uc004dwd.1_Missense_Mutation_p.I164K	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	206						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						CTCTTCCTCTATCCCTTCCCT	0.488													T	64749656	T	T	64749656	3	4	271	1	0	0	0	0	1	0	0	0	8636	449	16	5	1627	5	LAS1L	23	64749656	Missense_Mutation	SNP	A	TCGA-76-6283-01A-11D-1845-08	1874243	64749656	90520904	104	19482											
MED12	9968	broad.mit.edu	37	chrX	70357763	70357763	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgtgcaccagcaggcccccaCctatggacatggactgacct	10	15	0	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:70357763C>A	uc004dyy.2	+	41	6213	c.6014C>A	c.(6013-6015)ACC>AAC	p.T2005N	MED12_uc011mpq.1_Missense_Mutation_p.T1980N|MED12_uc004dyz.2_Missense_Mutation_p.T2004N|MED12_uc004dza.2_Missense_Mutation_p.T1855N|MED12_uc010nla.2_Missense_Mutation_p.T634N	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	2005	Gln-rich.|Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CAGGCCCCCACCTATGGACAT	0.547													A	70357763	A	A	70357763	3	1	271	1	0	0	0	0	1	0	0	0	9428	507	18	5	6176	5	MED12	23	70357763	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	5608107	70357763	84912797	105	19483											
TBX22	50945	broad.mit.edu	37	chrX	79282236	79282236	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccatgcataagtacaaacccCgagtgcacgtgatagagcaa	9	11	0	2			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:79282236C>A	uc010nmg.1	+	6	801	c.667C>A	c.(667-669)CGA>AGA	p.R223R	TBX22_uc004edi.1_Silent_p.R103R|TBX22_uc004edj.1_Silent_p.R223R	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	223	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						GTACAAACCCCGAGTGCACGT	0.453													A	79282236	A	A	79282236	2	1	271	1	0	0	0	0	0	0	0	1	15655	644	23	5		5	TBX22	23	79282236	Silent	SNP	C	TCGA-76-6283-01A-11D-1845-08	8924473	79282236	75988324	106	19484											
KLHL4	56062	broad.mit.edu	37	chrX	86890583	86890583	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attatatgctattggtggacGtgatggaagttcctgcctca	11	7	1	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:86890583G>A	uc004efb.2	+	9	1915	c.1733G>A	c.(1732-1734)CGT>CAT	p.R578H	KLHL4_uc004efa.2_Missense_Mutation_p.R578H	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	578	Kelch 4.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						ATTGGTGGACGTGATGGAAGT	0.393													A	86890583	A	A	86890583	3	1	271	1	0	0	0	0	1	0	0	0	8391	1145	40	1	1767	1	KLHL4	23	86890583	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	7608347	86890583	68379977	107	19485											
PCDH11X	27328	broad.mit.edu	37	chrX	91133806	91133806	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagaattctgaatgggctaCcccaaacccagaaaacaggc	9	12	1	3			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:91133806C>T	uc004efk.1	+	2	3412	c.2567C>T	c.(2566-2568)ACC>ATC	p.T856I	PCDH11X_uc004efl.1_Missense_Mutation_p.T856I|PCDH11X_uc004efo.1_Missense_Mutation_p.T856I|PCDH11X_uc010nmv.1_Missense_Mutation_p.T856I|PCDH11X_uc004efm.1_Missense_Mutation_p.T856I|PCDH11X_uc004efn.1_Missense_Mutation_p.T856I|PCDH11X_uc004efh.1_Missense_Mutation_p.T856I|PCDH11X_uc004efj.1_Missense_Mutation_p.T856I	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	856	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						GAATGGGCTACCCCAAACCCA	0.368													T	91133806	T	T	91133806	3	4	271	1	0	0	0	0	1	0	0	0	11508	507	18	3	2573	3	PCDH11X	23	91133806	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	4243223	91133806	64136754	108	19486											
TAF7L	54457	broad.mit.edu	37	chrX	100541563	100541563	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatggatattaactacttacGcaataagtcaatttttagtt	5	5	1	0	rs149116664		TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:100541563G>A	uc004ehb.2	-	3	415	c.403C>T	c.(403-405)CCT>TCT	p.P135S	TAF7L_uc004eha.2_Missense_Mutation_p.P49S|TAF7L_uc004ehc.1_Missense_Mutation_p.P49S	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	135					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						AACTACTTACGCAATAAGTCA	0.204													A	100541563	A	A	100541563	3	1	271	1	0	0	0	0	1	0	0	0	15530	1101	38	1	1029	1	TAF7L	23	100541563	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	9407757	100541563	54728997	109	19487											
ACSL4	2182	broad.mit.edu	37	chrX	108924259	108924259	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tagatcccaactcttctactGattgcatgctgtgaatctca	6	11	3	3			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:108924259G>T	uc004eoi.2	-	7	1251	c.746C>A	c.(745-747)TCA>TAA	p.S249*	ACSL4_uc004eoj.2_Nonsense_Mutation_p.S208*|ACSL4_uc004eok.2_Nonsense_Mutation_p.S208*|ACSL4_uc010npp.1_Nonsense_Mutation_p.S249*	NM_022977	NP_075266	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	249	Cytoplasmic (Potential).				fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)	CTCTTCTACTGATTGCATGCT	0.333													T	108924259	T	T	108924259	4	4	271	1	0	0	0	0	0	1	0	0	179	1294	45	5	1433	5	ACSL4	23	108924259	Nonsense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	8382696	108924259	46346301	110	19488											
UPF3B	65109	broad.mit.edu	37	chrX	118975081	118975084	+	Frame_Shift_Del	DEL	TCTG	-	-													aatttgtccctttctggaatTctgtctatcttctttagctt					rs142862074	byFrequency	TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:118975081_118975084delTCTG	uc004erz.1	-	7	839_842	c.762_765delCAGA	c.(760-765)GACAGAfs	p.D254fs	UPF3B_uc004esa.1_Frame_Shift_Del_p.D254fs	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	254_255	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding	p.R255K(1)		ovary(2)|kidney(1)	3						TTTCTGGAATTCTGTCTATCTTCT	0.191													-	118975084	-	-	118975081	7	5	271	1	0	1	0	1	0	0	0	0	17003	1780	62	0	706	0	UPF3B	23	118975081	Frame_Shift_Del	DEL	TCTG	TCGA-76-6283-01A-11D-1845-08	10050822	118975081	36295479	111	19489											
DCAF12L1	139170	broad.mit.edu	37	chrX	125685564	125685564	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccctctcgagaacacaggGgccggatgttctgctggtcc	12	14	2	1			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:125685564G>A	uc004eul.2	-	1	1279	c.1028C>T	c.(1027-1029)CCC>CTC	p.P343L		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	343										skin(3)|ovary(1)	4						AGAACACAGGGGCCGGATGTT	0.602													A	125685564	A	A	125685564	3	1	271	1	0	0	0	0	1	0	0	0	4264	1232	43	3	367	3	DCAF12L1	23	125685564	Missense_Mutation	SNP	G	TCGA-76-6283-01A-11D-1845-08	6710483	125685564	29584996	112	19490											
MST4	51765	broad.mit.edu	37	chrX	131207025	131207025	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	taacgctagcaggaatcaggCgattgaagaactcgagaaaa	11	7	1	3			TCGA-76-6283-01A-11D-1845-08	TCGA-76-6283-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a4083f8b-0c39-4d65-a372-b494caf84f8d	e66a84ab-f82a-4b35-a820-29122856f23e	g.chrX:131207025C>T	uc004ewk.1	+	11	1431	c.1130C>T	c.(1129-1131)GCG>GTG	p.A377V	MST4_uc004ewl.1_Missense_Mutation_p.A300V|MST4_uc011mux.1_Missense_Mutation_p.A399V|MST4_uc010nrj.1_Missense_Mutation_p.A353V|MST4_uc004ewm.1_Missense_Mutation_p.A315V	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	377					cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					AGGAATCAGGCGATTGAAGAA	0.358													T	131207025	T	T	131207025	3	4	271	1	0	0	0	0	1	0	0	0	9892	768	27	1	1168	1	MST4	23	131207025	Missense_Mutation	SNP	C	TCGA-76-6283-01A-11D-1845-08	5521461	131207025	24063535	113	19491											
LOC649330	649330	broad.mit.edu	37	chr1	12908039	12908039	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgccatacttggaaaagatcGcctccacatccgatttcttg	7	12	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr1:12908039G>A	uc009vno.2	-	1	199	c.104C>T	c.(103-105)GCG>GTG	p.A35V	HNRNPCL1_uc010obf.1_Missense_Mutation_p.A35V	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	35							nucleic acid binding|nucleotide binding				0						GGAAAAGATCGCCTCCACATC	0.473													A	12908039	A	A	12908039	3	1	272	1	0	0	0	0	1	0	0	0	8885	1087	38	1	781	1	LOC649330	1	12908039	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08		12908039	236342582	1	19492											
CSMD2	114784	broad.mit.edu	37	chr1	34123559	34123559	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttgtaccgatgcatgttggCgggctgggctgccagaagaa	15	8	0	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr1:34123559C>T	uc001bxn.1	-	27	4343	c.4314G>A	c.(4312-4314)CCG>CCA	p.P1438P	CSMD2_uc001bxm.1_Silent_p.P1478P|CSMD2_uc001bxo.1_Silent_p.P351P	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1438	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGCATGTTGGCGGGCTGGGCT	0.572													T	34123559	T	T	34123559	2	4	272	1	0	0	0	0	0	0	0	1	3945	755	27	1		1	CSMD2	1	34123559	Silent	SNP	C	TCGA-76-6285-01A-11D-1696-08	21215520	34123559	215127062	2	19493											
TIE1	7075	broad.mit.edu	37	chr1	43774798	43774798	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	caagccagacggcactgtgcTcctggtcagcccccaatcac	9	17	2	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr1:43774798T>A	uc001ciu.2	+	8	1263	c.1184T>A	c.(1183-1185)CTC>CAC	p.L395H	TIE1_uc010okd.1_Missense_Mutation_p.L395H|TIE1_uc010oke.1_Missense_Mutation_p.L350H|TIE1_uc009vwq.2_Missense_Mutation_p.L351H|TIE1_uc010okf.1_Missense_Mutation_p.L40H|TIE1_uc010okg.1_Missense_Mutation_p.L40H|TIE1_uc010okc.1_Intron	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	395	Ig-like C2-type 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGCACTGTGCTCCTGGTCAGC	0.617													A	43774798	A	A	43774798	3	1	272	1	0	0	0	0	1	0	0	0	15890	1551	54	5	1214	5	TIE1	1	43774798	Missense_Mutation	SNP	T	TCGA-76-6285-01A-11D-1696-08	9651239	43774798	205475823	3	19494											
C8A	731	broad.mit.edu	37	chr1	57341829	57341829	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagatgtcagggccattgaCgaagactgcagccagtatga	13	8	1	4			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr1:57341829C>T	uc001cyo.2	+	4	543	c.411C>T	c.(409-411)GAC>GAT	p.D137D		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	137	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GGGCCATTGACGAAGACTGCA	0.532													T	57341829	T	T	57341829	2	4	272	1	0	0	0	0	0	0	0	1	2416	535	19	1		1	C8A	1	57341829	Silent	SNP	C	TCGA-76-6285-01A-11D-1696-08	13567031	57341829	191908792	4	19495											
FLG	2312	broad.mit.edu	37	chr1	152275685	152275685	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ggagccatctcttgactgctCccgagaagatccatgatggt	11	11	1	4			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr1:152275685C>A	uc001ezu.1	-	3	11713	c.11677G>T	c.(11677-11679)GAG>TAG	p.E3893*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3893	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGACTGCTCCCGAGAAGAT	0.537									Ichthyosis				A	152275685	A	A	152275685	4	1	272	1	0	0	0	0	0	1	0	0	5922	864	30	5	512	5	FLG	1	152275685	Nonsense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	94933856	152275685	96974936	5	19496											
CD1D	912	broad.mit.edu	37	chr1	158153826	158153826	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccggtttaagaggcaaacGtaagtctcccctttcccttt	7	13	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr1:158153826G>A	uc001frr.2	+	6	1485	c.986_splice	c.e6+1	p.T329_splice	CD1D_uc009wss.2_Splice_Site_p.T236_splice	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor						antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					AGAGGCAAACGTAAGTCTCCC	0.512													A	158153826	A	A	158153826	5	1	272	1	0	0	0	0	0	0	1	0	2977	1159	40	1	1005	1	CD1D	1	158153826	Splice_Site	SNP	G	TCGA-76-6285-01A-11D-1696-08	5878141	158153826	91096795	6	19497											
SH3BP5L	80851	broad.mit.edu	37	chr1	249106332	249106332	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ccccaggctgctgccctcctCcagccccgcaccctcggccc	8	25	0	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr1:249106332C>A	uc001iew.1	-	7	1501	c.949G>T	c.(949-951)GAG>TAG	p.E317*	SH3BP5L_uc010pzp.1_Nonsense_Mutation_p.E210*|SH3BP5L_uc010pzq.1_Nonsense_Mutation_p.E285*|SH3BP5L_uc001iev.1_Nonsense_Mutation_p.E198*	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	317											0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CTGCCCTCCTCCAGCCCCGCA	0.731													A	249106332	A	A	249106332	4	1	272	1	0	0	0	0	0	1	0	0	14248	864	30	5	236	5	SH3BP5L	1	249106332	Nonsense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	90952506	249106332	144289	7	19498											
SP3	6670	broad.mit.edu	37	chr2	174820235	174820235	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtaacaggcaactgtgatgaAgaggatgttggcacaaataa	12	5	0	3			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr2:174820235A>G	uc002uig.2	-	4	1169	c.1005T>C	c.(1003-1005)TCT>TCC	p.S335S	SP3_uc002uie.2_Silent_p.S267S|SP3_uc002uif.2_Silent_p.S282S|SP3_uc010zel.1_Silent_p.S332S	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	335					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)			ACTGTGATGAAGAGGATGTTG	0.378													G	174820235	G	G	174820235	2	3	272	1	0	0	0	0	0	0	0	1	14965	59	3	4		4	SP3	2	174820235	Silent	SNP	A	TCGA-76-6285-01A-11D-1696-08		174820235	68379138	8	19499											
GPR1	2825	broad.mit.edu	37	chr2	207041266	207041266	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggagatcaggatgcttcGcttcttcaccttgaagatga	10	9	3	4	rs34685097		TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr2:207041266G>A	uc002vbl.3	-	3	1092	c.706C>T	c.(706-708)CGA>TGA	p.R236*	GPR1_uc010fue.2_Nonsense_Mutation_p.R236*|GPR1_uc010fuf.2_Nonsense_Mutation_p.R236*	NM_005279	NP_005270	P46091	GPR1_HUMAN	G protein-coupled receptor 1	236	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		AGGATGCTTCGCTTCTTCACC	0.438													A	207041266	A	A	207041266	4	1	272	1	0	0	0	0	0	1	0	0	6621	1095	38	1	365	1	GPR1	2	207041266	Nonsense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	32221031	207041266	36158107	9	19500											
COPS7B	64708	broad.mit.edu	37	chr2	232653347	232653347	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ttttactagccaaaggtaccAgtggctcagccctcactgct	8	13	2	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr2:232653347A>T	uc002vsg.1	+	2	170	c.67A>T	c.(67-69)AGT>TGT	p.S23C	COPS7B_uc010fxy.1_Intron|COPS7B_uc002vsh.1_Missense_Mutation_p.S23C|COPS7B_uc002vsi.1_5'UTR|COPS7B_uc002vsj.1_5'Flank	NM_022730	NP_073567	Q9H9Q2	CSN7B_HUMAN	COP9 constitutive photomorphogenic homolog	23					cullin deneddylation	cytoplasm|signalosome				ovary(1)|liver(1)|skin(1)	3		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;1.36e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00136)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CAAAGGTACCAGTGGCTCAGC	0.493													T	232653347	T	T	232653347	3	4	272	1	0	0	0	0	1	0	0	0	3739	188	7	5	69	5	COPS7B	2	232653347	Missense_Mutation	SNP	A	TCGA-76-6285-01A-11D-1696-08	25612081	232653347	10546026	10	19501											
CNTN6	27255	broad.mit.edu	37	chr3	1339608	1339608	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atgaaccaaagattgaagtgCgttttcctgaaactatacaa	7	7	0	4			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr3:1339608C>T	uc003boz.2	+	7	961	c.694C>T	c.(694-696)CGT>TGT	p.R232C	CNTN6_uc010hbo.2_Missense_Mutation_p.R227C|CNTN6_uc011asj.1_Missense_Mutation_p.R160C|CNTN6_uc003bpa.2_Missense_Mutation_p.R232C	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	232	Ig-like C2-type 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GATTGAAGTGCGTTTTCCTGA	0.338													T	1339608	T	T	1339608	3	4	272	1	0	0	0	0	1	0	0	0	3645	768	27	1	716	1	CNTN6	3	1339608	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08		1339608	196682822	11	19502											
FBLN2	2199	broad.mit.edu	37	chr3	13613045	13613045	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cacatcactgcctgatgcagCctggatcccacccacccgag	8	18	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr3:13613045C>A	uc011avb.1	+	2	1315	c.1190C>A	c.(1189-1191)GCC>GAC	p.A397D	FBLN2_uc011auz.1_Missense_Mutation_p.A423D|FBLN2_uc011ava.1_Missense_Mutation_p.A397D|FBLN2_uc011avc.1_Missense_Mutation_p.A397D	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	397	Subdomain NB (Cys-free).|N.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CCTGATGCAGCCTGGATCCCA	0.622													A	13613045	A	A	13613045	3	1	272	1	0	0	0	0	1	0	0	0	5699	739	26	5		5	FBLN2	3	13613045	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	12273437	13613045	184409385	12	19503											
TRH	7200	broad.mit.edu	37	chr3	129696024	129696024	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcggcagcaccctggtcggCgggcagcctgggtcagagag	18	12	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr3:129696024C>T	uc003enc.2	+	3	1255	c.694C>T	c.(694-696)CGG>TGG	p.R232W		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	232					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						CCCTGGTCGGCGGGCAGCCTG	0.622													T	129696024	T	T	129696024	3	4	272	1	0	0	0	0	1	0	0	0	16475	759	27	1	700	1	TRH	3	129696024	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	116082979	129696024	68326406	13	19504											
HLTF	6596	broad.mit.edu	37	chr3	148768105	148768105	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctctaatacgatcaggacCataataaacataaaaattca	3	8	3	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr3:148768105C>T	uc003ewq.1	-	15	1749	c.1531G>A	c.(1531-1533)GGT>AGT	p.G511S	HLTF_uc003ewr.1_Missense_Mutation_p.G511S|HLTF_uc003ews.1_Missense_Mutation_p.G510S|HLTF_uc010hve.1_Missense_Mutation_p.G510S	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	511	Helicase ATP-binding.				chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CGATCAGGACCATAATAAACA	0.299													T	148768105	T	T	148768105	3	4	272	1	0	0	0	0	1	0	0	0	7215	594	21	3	1542	3	HLTF	3	148768105	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	19072081	148768105	49254325	14	19505											
ACCN5	51802	broad.mit.edu	37	chr4	156764907	156764907	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	taacccatcaaactgtggcaCcttctttggtgaatggataa	8	9	2	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr4:156764907C>A	uc003ipe.1	-	5	834	c.787G>T	c.(787-789)GTG>TTG	p.V263L		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	263	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		AACTGTGGCACCTTCTTTGGT	0.453													A	156764907	A	A	156764907	3	1	272	1	0	0	0	0	1	0	0	0	132	507	18	5	754	5	ACCN5	4	156764907	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08		156764907	34389369	15	19506											
TAS2R1	50834	broad.mit.edu	37	chr5	9629468	9629468	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggacaggatagacagcaacGcgctgatgggtgcacccctg	14	11	0	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr5:9629468G>A	uc003jem.1	-	1	996	c.677C>T	c.(676-678)GCG>GTG	p.A226V		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	226	Helical; Name=6; (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						AGACAGCAACGCGCTGATGGG	0.498													A	9629468	A	A	9629468	3	1	272	1	0	0	0	0	1	0	0	0	15562	1087	38	1	226	1	TAS2R1	5	9629468	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08		9629468	171285792	16	19507											
ITGA2	3673	broad.mit.edu	37	chr5	52344242	52344242	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgggaatcagtattacacaaCgggtgtgtgttctgacatca	11	7	3	1	rs148042733		TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr5:52344242C>T	uc003joy.2	+	5	580	c.437C>T	c.(436-438)ACG>ATG	p.T146M	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.T70M|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	146	Extracellular (Potential).|FG-GAP 2.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TATTACACAACGGGTGTGTGT	0.438													T	52344242	T	T	52344242	3	4	272	1	0	0	0	0	1	0	0	0	7875	536	19	1	455	1	ITGA2	5	52344242	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	42714774	52344242	128571018	17	19508											
RGNEF	64283	broad.mit.edu	37	chr5	73148496	73148496	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcaaagagcttacagcttatCggagccaccaagagaaaaca	9	10	0	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr5:73148496C>T	uc011csq.1	+	13	1780	c.1769C>T	c.(1768-1770)TCG>TTG	p.S590L	RGNEF_uc003kcx.2_Missense_Mutation_p.S590L|RGNEF_uc003kcy.1_3'UTR|RGNEF_uc010izf.2_Missense_Mutation_p.S590L|RGNEF_uc011csr.1_Missense_Mutation_p.S277L	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	590					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		TACAGCTTATCGGAGCCACCA	0.378													T	73148496	T	T	73148496	3	4	272	1	0	0	0	0	1	0	0	0	13283	893	31	2	1819	2	RGNEF	5	73148496	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	20804254	73148496	107766764	18	19509											
SLC27A6	28965	broad.mit.edu	37	chr5	128368954	128368954	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaactttatgatcaaataatGttaggggaaataaaacttta	7	3	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr5:128368954G>T	uc003kuy.2	+	11	2235	c.1839G>T	c.(1837-1839)ATG>ATT	p.M613I	SLC27A6_uc003kuz.2_Missense_Mutation_p.M613I	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	613					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		ATCAAATAATGTTAGGGGAAA	0.318													T	128368954	T	T	128368954	3	4	272	1	0	0	0	0	1	0	0	0	14530	1377	48	5	1877	5	SLC27A6	5	128368954	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	55220458	128368954	52546306	19	19510											
HLA-DOA	3111	broad.mit.edu	37	chr6	32975124	32975124	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggcgcatccaggccccagtGctccacctggcagtcataga	11	15	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr6:32975124G>A	uc003ocr.2	-	3	653	c.577C>T	c.(577-579)CAC>TAC	p.H193Y	HLA-DOA_uc010juj.2_Missense_Mutation_p.H163Y|HLA-DOA_uc010jui.2_Missense_Mutation_p.H193Y	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	193	Extracellular (Potential).|Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						AGGCCCCAGTGCTCCACCTGG	0.597													A	32975124	A	A	32975124	3	1	272	1	0	0	0	0	1	0	0	0	7200	1319	46	3	187	3	HLA-DOA	6	32975124	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08		32975124	138139943	20	19511											
VPS52	6293	broad.mit.edu	37	chr6	33238055	33238055	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggttcctggagcccaggaccAcccgcctggaaagggataag	14	12	0	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr6:33238055A>C	uc003odm.1	-	2	306	c.96T>G	c.(94-96)GGT>GGG	p.G32G	VPS52_uc003odn.1_5'UTR|VPS52_uc003odo.1_5'UTR|VPS52_uc011dqy.1_5'UTR|VPS52_uc011dqz.1_5'UTR|RPS18_uc003odp.1_5'Flank|RPS18_uc010jum.1_5'Flank|RPS18_uc003odq.1_5'Flank	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	32					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						GCCCAGGACCACCCGCCTGGA	0.483													C	33238055	C	C	33238055	2	2	272	1	0	0	0	0	0	0	0	1	17211	146	6	5		5	VPS52	6	33238055	Silent	SNP	A	TCGA-76-6285-01A-11D-1696-08	262931	33238055	137877012	21	19512											
TBX18	9096	broad.mit.edu	37	chr6	85446874	85446874	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acataggagggagtcctgggCggggcaaaggtctcaccagc	16	10	1	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr6:85446874C>T	uc003pkl.1	-	8	1353	c.1353G>A	c.(1351-1353)CCG>CCA	p.P451P	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	451					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GAGTCCTGGGCGGGGCAAAGG	0.612													T	85446874	T	T	85446874	2	4	272	1	0	0	0	0	0	0	0	1	15650	755	27	1		1	TBX18	6	85446874	Silent	SNP	C	TCGA-76-6285-01A-11D-1696-08	52208819	85446874	85668193	22	19513											
TPD52L1	7164	broad.mit.edu	37	chr6	125541243	125541243	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtttgttggagactgaaccGttgcaaggaacagacgaaga	14	6	0	4			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr6:125541243G>A	uc003pzu.1	+	2	258	c.39G>A	c.(37-39)CCG>CCA	p.P13P	TPD52L1_uc003pzv.1_Silent_p.P13P|TPD52L1_uc003pzw.1_Silent_p.P13P|TPD52L1_uc003pzx.1_5'UTR|TPD52L1_uc003pzy.1_5'UTR|TPD52L1_uc003pzz.1_5'UTR	NM_003287	NP_003278	Q16890	TPD53_HUMAN	tumor protein D52-like 1 isoform 1	13					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		AGACTGAACCGTTGCAAGGAA	0.348													A	125541243	A	A	125541243	2	1	272	1	0	0	0	0	0	0	0	1	16395	1132	40	1		1	TPD52L1	6	125541243	Silent	SNP	G	TCGA-76-6285-01A-11D-1696-08	40094369	125541243	45573824	23	19514											
SYNJ2	8871	broad.mit.edu	37	chr6	158454502	158454502	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgcaggaaccagctgttgcaCgtgcccttgaggcagcacca	12	13	0	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr6:158454502C>T	uc003qqx.1	+	4	576	c.501C>T	c.(499-501)CAC>CAT	p.H167H	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Silent_p.H167H|SYNJ2_uc003qqy.1_Translation_Start_Site|SYNJ2_uc011efn.1_Silent_p.H116H|SYNJ2_uc010kjo.1_Silent_p.H116H	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	167	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		AGCTGTTGCACGTGCCCTTGA	0.572													T	158454502	T	T	158454502	2	4	272	1	0	0	0	0	0	0	0	1	15450	535	19	1		1	SYNJ2	6	158454502	Silent	SNP	C	TCGA-76-6285-01A-11D-1696-08	32913259	158454502	12660565	24	19515											
SYNJ2	8871	broad.mit.edu	37	chr6	158483049	158483049	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctctgggcttcttgccacgCgggcgacacgcctatgatca	12	14	3	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr6:158483049C>T	uc003qqx.1	+	8	1055	c.980C>T	c.(979-981)GCG>GTG	p.A327V	SYNJ2_uc011efm.1_Intron|SYNJ2_uc003qqw.1_Missense_Mutation_p.A327V|SYNJ2_uc003qqy.1_Missense_Mutation_p.A40V|SYNJ2_uc011efn.1_Intron|SYNJ2_uc010kjo.1_Missense_Mutation_p.A276V|SYNJ2_uc003qqz.1_5'UTR	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	327	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		TCTTGCCACGCGGGCGACACG	0.383													T	158483049	T	T	158483049	3	4	272	1	0	0	0	0	1	0	0	0	15450	768	27	1	1010	1	SYNJ2	6	158483049	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	28547	158483049	12632018	25	19516											
AGPAT4	56895	broad.mit.edu	37	chr6	161587289	161587289	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctgacttacccctaacagCccaaagcgttcggacaggct	8	14	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr6:161587289C>T	uc003qtr.1	-	3	566	c.339G>A	c.(337-339)GGG>GGA	p.G113G	AGPAT4_uc003qts.1_Intron|AGPAT4_uc011egb.1_Intron|AGPAT4_uc003qtt.1_RNA|AGPAT4_uc011egc.1_Silent_p.G113G|AGPAT4_uc011egd.1_Silent_p.G51G|AGPAT4_uc011ege.1_Intron	NM_020133	NP_064518	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	113					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding				0		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		CCCCTAACAGCCCAAAGCGTT	0.507													T	161587289	T	T	161587289	2	4	272	1	0	0	0	0	0	0	0	1	389	726	26	3		3	AGPAT4	6	161587289	Silent	SNP	C	TCGA-76-6285-01A-11D-1696-08	3104240	161587289	9527778	26	19517											
TYW1	55253	broad.mit.edu	37	chr7	66532361	66532361	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaaccaccccgagcttggcGtgtgctaataaatgtgtctt	10	10	1	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr7:66532361G>A	uc003tvn.2	+	10	1394	c.1245G>A	c.(1243-1245)GCG>GCA	p.A415A	TYW1_uc010lai.2_RNA|TYW1_uc011kef.1_Silent_p.A29A	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	415					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				CGAGCTTGGCGTGTGCTAATA	0.458													A	66532361	A	A	66532361	2	1	272	1	0	0	0	0	0	0	0	1	16815	1132	40	1		1	TYW1	7	66532361	Silent	SNP	G	TCGA-76-6285-01A-11D-1696-08		66532361	92606302	27	19518											
C7orf51	222950	broad.mit.edu	37	chr7	100086489	100086489	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctgcacgggagcgggagaCgcctcccccaccgcctccac	12	20	0	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr7:100086489C>T	uc003uvd.1	+	4	1304	c.1145C>T	c.(1144-1146)ACG>ATG	p.T382M	C7orf51_uc003uve.1_Missense_Mutation_p.T164M	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	382	Pro-rich.									skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAGCGGGAGACGCCTCCCCCA	0.706													T	100086489	T	T	100086489	3	4	272	1	0	0	0	0	1	0	0	0	2400	536	19	1	1155	1	C7orf51	7	100086489	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	33554128	100086489	59052174	28	19519											
RELN	5649	broad.mit.edu	37	chr7	103341383	103341383	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctctagctgaatccagtcCgcagagttattcttggcata	8	10	2	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr7:103341383C>T	uc003vca.2	-	9	1036	c.876G>A	c.(874-876)GCG>GCA	p.A292A	RELN_uc010liz.2_Silent_p.A292A	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	292					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAATCCAGTCCGCAGAGTTAT	0.358													T	103341383	T	T	103341383	2	4	272	1	0	0	0	0	0	0	0	1	13220	639	23	2		2	RELN	7	103341383	Silent	SNP	C	TCGA-76-6285-01A-11D-1696-08	3254894	103341383	55797280	29	19520											
SPAM1	6677	broad.mit.edu	37	chr7	123595133	123595133	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gggaaccctcagtataatgcGaagtatggtaagttgaattg	12	5	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr7:123595133G>A	uc003vld.2	+	5	1439	c.1037G>A	c.(1036-1038)CGA>CAA	p.R346Q	SPAM1_uc003vle.2_Missense_Mutation_p.R346Q|SPAM1_uc011koa.1_Missense_Mutation_p.R2Q|SPAM1_uc003vlf.3_Missense_Mutation_p.R346Q|SPAM1_uc010lku.2_Missense_Mutation_p.R346Q	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	346					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	AGTATAATGCGAAGTATGGTA	0.294													A	123595133	A	A	123595133	3	1	272	1	0	0	0	0	1	0	0	0	14986	1058	37	2	1043	2	SPAM1	7	123595133	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	20253750	123595133	35543530	30	19521											
CHRM2	1129	broad.mit.edu	37	chr7	136700700	136700700	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaagcagaatattgtagcccGcaagattgtgaagatgacta	10	6	0	5	rs147228075		TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr7:136700700G>A	uc003vtf.1	+	4	1711	c.1088G>A	c.(1087-1089)CGC>CAC	p.R363H	CHRM2_uc003vtg.1_Missense_Mutation_p.R363H|CHRM2_uc003vtj.1_Missense_Mutation_p.R363H|CHRM2_uc003vtk.1_Missense_Mutation_p.R363H|CHRM2_uc003vtl.1_Missense_Mutation_p.R363H|CHRM2_uc003vtm.1_Missense_Mutation_p.R363H|CHRM2_uc003vti.1_Missense_Mutation_p.R363H|CHRM2_uc003vto.1_Missense_Mutation_p.R363H|CHRM2_uc003vtn.1_Missense_Mutation_p.R363H|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	363	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ATTGTAGCCCGCAAGATTGTG	0.468													A	136700700	A	A	136700700	3	1	272	1	0	0	0	0	1	0	0	0	3377	1087	38	1	1090	1	CHRM2	7	136700700	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	13105567	136700700	22437963	31	19522											
EIF3E	3646	broad.mit.edu	37	chr8	109240547	109240547	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tatcgcgacctttggggtgaTtgaagaaaacaaacagagac	11	7	0	4			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr8:109240547T>C	uc003ymu.2	-	7	699	c.671A>G	c.(670-672)AAT>AGT	p.N224S	EIF3E_uc003ymt.2_Missense_Mutation_p.N175S|EIF3E_uc003ymv.2_Missense_Mutation_p.N131S|EIF3E_uc010mci.1_Missense_Mutation_p.N224S	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	224					negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			TTTGGGGTGATTGAAGAAAAC	0.343													C	109240547	C	C	109240547	3	2	272	1	0	0	0	0	1	0	0	0	5015	1493	52	4	694	4	EIF3E	8	109240547	Missense_Mutation	SNP	T	TCGA-76-6285-01A-11D-1696-08		109240547	37123475	32	19523											
BAI1	575	broad.mit.edu	37	chr8	143558906	143558906	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctgcaacattgccctgtgCcctggtaggtgagagggagg	15	9	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr8:143558906C>T	uc003ywm.2	+	5	1566	c.1383C>T	c.(1381-1383)TGC>TGT	p.C461C		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	461	Extracellular (Potential).|TSP type-1 3.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TTGCCCTGTGCCCTGGTAGGT	0.657													T	143558906	T	T	143558906	2	4	272	1	0	0	0	0	0	0	0	1	1298	747	26	3		3	BAI1	8	143558906	Silent	SNP	C	TCGA-76-6285-01A-11D-1696-08	34318359	143558906	2805116	33	19524											
METTL11A	28989	broad.mit.edu	37	chr9	132394975	132394975	+	Translation_Start_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgagtagagccgtggttgGtgacagcatgacgagcgagg	17	7	0	4			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr9:132394975G>A	uc004byd.1	+	2	187	c.-7G>A	c.(-9--5)TGGTG>TGATG		METTL11A_uc010myw.1_RNA|METTL11A_uc011mbs.1_Translation_Start_Site	NM_014064	NP_054783	Q9BV86	NTM1A_HUMAN	methyltransferase like 11A						chromosome segregation|N-terminal peptidyl-proline dimethylation|N-terminal peptidyl-serine dimethylation|N-terminal peptidyl-serine trimethylation|spindle organization	nucleus	protein binding|protein methyltransferase activity				0						GCCGTGGTTGGTGACAGCATG	0.577													A	132394975	A	A	132394975	1	1	272	1	0	0	0	0	0	0	0	0	9495	1276	44	3		3	METTL11A	9	132394975	Translation_Start_Site	SNP	G	TCGA-76-6285-01A-11D-1696-08		132394975	8818456	34	19525											
HPSE2	60495	broad.mit.edu	37	chr10	100249842	100249842	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagtgagcataaatccttaGtttgtcccggatcactcggc	10	11	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr10:100249842G>A	uc001kpn.1	-	10	1492	c.1432C>T	c.(1432-1434)CTA>TTA	p.L478L	HPSE2_uc009xwc.1_Silent_p.L468L|HPSE2_uc001kpo.1_Silent_p.L410L|HPSE2_uc009xwd.1_Silent_p.L356L	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	478					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TAAATCCTTAGTTTGTCCCGG	0.577													A	100249842	A	A	100249842	2	1	272	1	0	0	0	0	0	0	0	1	7345	1020	36	3		3	HPSE2	10	100249842	Silent	SNP	G	TCGA-76-6285-01A-11D-1696-08		100249842	35284905	35	19526											
AP2A2	161	broad.mit.edu	37	chr11	926039	926039	+	Frame_Shift_Del	DEL	G	-	-													aagatgccggccgtgtccaaGggggacgggatgcggggcct							TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr11:926039delG	uc001lss.2	+	1	199	c.18delG	c.(16-18)AAGfs	p.K6fs	AP2A2_uc001lst.1_Frame_Shift_Del_p.K6fs|AP2A2_uc009yco.1_RNA	NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	6	Lipid-binding.				axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCGTGTCCAAGGGGGACGGGA	0.572													-	926039	-	-	926039	7	5	272	1	0	1	0	1	0	0	0	0	740	991	35	0	20	0	AP2A2	11	926039	Frame_Shift_Del	DEL	G	TCGA-76-6285-01A-11D-1696-08		926039	134080477	36	19527											
MUC6	4588	broad.mit.edu	37	chr11	1025025	1025025	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgccacgtacctgctgcgcGtctcgaagtcgtccttcatg	10	14	2	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr11:1025025G>A	uc001lsw.2	-	24	3095	c.3044C>T	c.(3043-3045)ACG>ATG	p.T1015M		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1015	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCTGCTGCGCGTCTCGAAGTC	0.637													A	1025025	A	A	1025025	3	1	272	1	0	0	0	0	1	0	0	0	9980	1145	40	1	4315	1	MUC6	11	1025025	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	98986	1025025	133981491	37	19528											
NAV2	89797	broad.mit.edu	37	chr11	19955730	19955730	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctgtcgggaccacccagaCcacaggaagcaataccgtca	10	14	2	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr11:19955730C>T	uc010rdm.1	+	8	2370	c.2009C>T	c.(2008-2010)ACC>ATC	p.T670I	NAV2_uc001mpp.2_Missense_Mutation_p.T583I|NAV2_uc001mpr.3_Missense_Mutation_p.T647I	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	670						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						ACCACCCAGACCACAGGAAGC	0.582													T	19955730	T	T	19955730	3	4	272	1	0	0	0	0	1	0	0	0	10184	507	18	3	2045	3	NAV2	11	19955730	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	18930705	19955730	115050786	38	19529											
CHRDL2	25884	broad.mit.edu	37	chr11	74429781	74429781	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctacctctgagcaggtacagCgcaggcagtacatcaggcct	11	13	2	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr11:74429781C>T	uc001ovi.2	-	2	432	c.179G>A	c.(178-180)CGC>CAC	p.R60H	CHRDL2_uc001ovg.2_5'UTR|CHRDL2_uc001ovh.2_Missense_Mutation_p.R60H|CHRDL2_uc001ovk.1_Missense_Mutation_p.R60H			Q6WN34	CRDL2_HUMAN	RecName: Full=Chordin-like protein 2; AltName: Full=Chordin-related protein 2; AltName: Full=Breast tumor novel factor 1;          Short=BNF-1; Flags: Precursor;	60	VWFC 1.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion					0	Hepatocellular(1;0.098)					GCAGGTACAGCGCAGGCAGTA	0.597													T	74429781	T	T	74429781	3	4	272	1	0	0	0	0	1	0	0	0	3374	768	27	1	1220	1	CHRDL2	11	74429781	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	54474051	74429781	60576735	39	19530											
PIK3C2G	5288	broad.mit.edu	37	chr12	18658397	18658397	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catttggagggataaaaaggTcagtgcacaaatgtttatta	10	4	1	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr12:18658397T>C	uc001rdt.2	+	23	3316	c.3200_splice	c.e23+2	p.R1067_splice	PIK3C2G_uc010sia.1_Splice_Site|PIK3C2G_uc010sib.1_Splice_Site_p.R1108_splice|PIK3C2G_uc010sic.1_Splice_Site_p.R886_splice	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma						cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GATAAAAAGGTCAGTGCACAA	0.368													C	18658397	C	C	18658397	5	2	272	1	0	0	0	0	0	0	1	0	11911	1681	58	4	3288	4	PIK3C2G	12	18658397	Splice_Site	SNP	T	TCGA-76-6285-01A-11D-1696-08		18658397	115193498	40	19531											
KRT6B	3854	broad.mit.edu	37	chr12	52841112	52841112	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgcctccaacgccaagaccActgccataggagtagctgct	9	16	0	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr12:52841112A>G	uc001sak.2	-	9	1605	c.1557T>C	c.(1555-1557)AGT>AGC	p.S519S		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	519	Tail.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		CGCCAAGACCACTGCCATAGG	0.622													G	52841112	G	G	52841112	2	3	272	1	0	0	0	0	0	0	0	1	8481	156	6	4		4	KRT6B	12	52841112	Silent	SNP	A	TCGA-76-6285-01A-11D-1696-08	34182715	52841112	81010783	41	19532											
GPR182	11318	broad.mit.edu	37	chr12	57389618	57389618	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	gcctcttcatggcaccttttGaaacgtacagcacctgggcc	9	14	2	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr12:57389618G>T	uc001smk.2	+	2	719	c.625G>T	c.(625-627)GAA>TAA	p.E209*	RDH16_uc010sqx.1_Intron	NM_007264	NP_009195	O15218	GP182_HUMAN	G protein-coupled receptor 182	209	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(1)	1						GGCACCTTTTGAAACGTACAG	0.617													T	57389618	T	T	57389618	4	4	272	1	0	0	0	0	0	1	0	0	6677	1291	45	5	627	5	GPR182	12	57389618	Nonsense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	4548506	57389618	76462277	42	19533											
RASSF9	9182	broad.mit.edu	37	chr12	86199112	86199112	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	ctgaacatagttttctccatCattttctactcgatcaagat	4	10	4	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr12:86199112C>G	uc001taf.1	-	2	1015	c.676G>C	c.(676-678)GAT>CAT	p.D226H		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	226	Potential.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						TTTTCTCCATCATTTTCTACT	0.398													G	86199112	G	G	86199112	3	3	272	1	0	0	0	0	1	0	0	0	13093	826	29	5	635	5	RASSF9	12	86199112	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	28809494	86199112	47652783	43	19534											
NR2C1	7181	broad.mit.edu	37	chr12	95445680	95445680	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attcgctaatgatgtaaccaCattggccaatgtacttaaat	6	8	0	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr12:95445680C>A	uc001tdm.3	-	8	1079	c.823G>T	c.(823-825)GTG>TTG	p.V275L	NR2C1_uc010suu.1_Missense_Mutation_p.V275L|NR2C1_uc001tdo.3_Missense_Mutation_p.V275L|NR2C1_uc001tdn.3_Missense_Mutation_p.V275L	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	275					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1						GATGTAACCACATTGGCCAAT	0.303													A	95445680	A	A	95445680	3	1	272	1	0	0	0	0	1	0	0	0	10622	478	17	5	1094	5	NR2C1	12	95445680	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	9246568	95445680	38406215	44	19535											
NOS1	4842	broad.mit.edu	37	chr12	117710328	117710328	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggacacggcggggaggccGtaccacttcagccccaggtc	14	14	1	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr12:117710328G>A	uc001twm.1	-	10	2387	c.1701C>T	c.(1699-1701)TAC>TAT	p.Y567Y		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	567					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CGGGGAGGCCGTACCACTTCA	0.612													A	117710328	A	A	117710328	2	1	272	1	0	0	0	0	0	0	0	1	10541	1140	40	1		1	NOS1	12	117710328	Silent	SNP	G	TCGA-76-6285-01A-11D-1696-08	22264648	117710328	16141567	45	19536											
GPR109B	8843	broad.mit.edu	37	chr12	123200222	123200222	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttgggcccagataagaggGgctccatggctcaccggagt	16	10	1	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr12:123200222G>A	uc001ucy.3	-	1	1218	c.1063C>T	c.(1063-1065)CCC>TCC	p.P355S	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	355	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	AGATAAGAGGGGCTCCATGGC	0.537													A	123200222	A	A	123200222	3	1	272	1	0	0	0	0	1	0	0	0	6626	1232	43	3	104	3	GPR109B	12	123200222	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	5489894	123200222	10651673	46	19537											
EML5	161436	broad.mit.edu	37	chr14	89130847	89130847	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaagtcttacctctaatatcCcaatcaatatgggttatgta	5	8	3	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr14:89130847C>T	uc001xxg.2	-	24	3585	c.3399G>A	c.(3397-3399)TGG>TGA	p.W1133*	EML5_uc001xxf.2_5'UTR|EML5_uc001xxh.1_Nonsense_Mutation_p.W272*	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1133						cytoplasm|microtubule				ovary(3)	3						CTCTAATATCCCAATCAATAT	0.308													T	89130847	T	T	89130847	4	4	272	1	0	0	0	0	0	1	0	0	5100	624	22	3	2618	3	EML5	14	89130847	Nonsense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08		89130847	18218693	47	19538											
HS3ST4	9951	broad.mit.edu	37	chr16	26147153	26147153	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggtgctggccttcaaaaacCggaccctcgggctgatcgat	12	12	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr16:26147153C>T	uc002dof.2	+	2	1347	c.955C>T	c.(955-957)CGG>TGG	p.R319W		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	319	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		CTTCAAAAACCGGACCCTCGG	0.552													T	26147153	T	T	26147153	3	4	272	1	0	0	0	0	1	0	0	0	7367	643	23	2	961	2	HS3ST4	16	26147153	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08		26147153	64207600	48	19539											
ZNF48	197407	broad.mit.edu	37	chr16	30409831	30409831	+	Silent	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cctcgaagtccctcacactcGggtgagccttttggcctgcc	10	16	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr16:30409831G>C	uc002dya.1	+	2	1319	c.1260G>C	c.(1258-1260)TCG>TCC	p.S420S	ZNF48_uc002dxz.1_Silent_p.S297S	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	420	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCTCACACTCGGGTGAGCCTT	0.692													C	30409831	C	C	30409831	2	2	272	1	0	0	0	0	0	0	0	1	17931	1103	39	5		5	ZNF48	16	30409831	Silent	SNP	G	TCGA-76-6285-01A-11D-1696-08	4262678	30409831	59944922	49	19540											
SHPK	23729	broad.mit.edu	37	chr17	3524530	3524530	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaacaaaagaaaaacttaCctgcatctgtcctctgggcc	7	12	2	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr17:3524530C>T	uc002fvz.1	-	5	926	c.823_splice	c.e5+1	p.V275_splice		NM_013276	NP_037408	Q9UHJ6	SHPK_HUMAN	carbohydrate kinase-like						carbohydrate metabolic process	cytoplasm	ATP binding|sedoheptulokinase activity			ovary(1)	1				COAD - Colon adenocarcinoma(5;0.0828)		GAAAAACTTACCTGCATCTGT	0.522													T	3524530	T	T	3524530	5	4	272	1	0	0	0	0	0	0	1	0	14290	521	18	3	624	3	SHPK	17	3524530	Splice_Site	SNP	C	TCGA-76-6285-01A-11D-1696-08		3524530	77670680	50	19541											
ACACA	31	broad.mit.edu	37	chr17	35631152	35631152	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctggggaacatttaagatacGttttgaaaaatcattttcct	7	6	1	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr17:35631152G>A	uc002hnm.2	-	9	1020	c.829C>T	c.(829-831)CGT>TGT	p.R277C	ACACA_uc002hnk.2_Missense_Mutation_p.R199C|ACACA_uc002hnl.2_Missense_Mutation_p.R219C|ACACA_uc002hnn.2_Missense_Mutation_p.R277C|ACACA_uc002hno.2_Missense_Mutation_p.R314C|ACACA_uc010cuz.2_Missense_Mutation_p.R277C|ACACA_uc002hnq.2_Missense_Mutation_p.R199C	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	277	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TTTAAGATACGTTTTGAAAAA	0.408													A	35631152	A	A	35631152	3	1	272	1	0	0	0	0	1	0	0	0	106	1145	40	1	6403	1	ACACA	17	35631152	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	32106622	35631152	45564058	51	19542											
AOC2	314	broad.mit.edu	37	chr17	40997352	40997352	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggtcttttccttcaccccGtggggctggagctactactg	11	12	2	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr17:40997352G>A	uc002ibu.2	+	1	744	c.709G>A	c.(709-711)GTG>ATG	p.V237M	AOC2_uc002ibt.2_Missense_Mutation_p.V237M	NM_009590	NP_033720	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 isoform b	237					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			ovary(2)	2		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CCTTCACCCCGTGGGGCTGGA	0.612													A	40997352	A	A	40997352	3	1	272	1	0	0	0	0	1	0	0	0	727	1145	40	1	711	1	AOC2	17	40997352	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	5366200	40997352	40197858	52	19543											
MYO5B	4645	broad.mit.edu	37	chr18	47463738	47463738	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gcaggaacagggtccttgtcAtcatgaaacaagtcagccac	10	11	3	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr18:47463738A>G	uc002leb.2	-	15	2070	c.1782T>C	c.(1780-1782)GAT>GAC	p.D594D	MYO5B_uc002lec.1_Silent_p.D593D	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	594	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GGTCCTTGTCATCATGAAACA	0.507													G	47463738	G	G	47463738	2	3	272	1	0	0	0	0	0	0	0	1	10079	214	8	4		4	MYO5B	18	47463738	Silent	SNP	A	TCGA-76-6285-01A-11D-1696-08		47463738	30613510	53	19544											
MIDN	90007	broad.mit.edu	37	chr19	1257154	1257154	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccggccgcagcgacagcagTagcagcgggggcggcggcag	20	13	0	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr19:1257154T>G	uc002lrp.2	+	8	1805	c.1290T>G	c.(1288-1290)AGT>AGG	p.S430R		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	430						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGACAGCAGTAGCAGCGGGG	0.682													G	1257154	G	G	1257154	3	3	272	1	0	0	0	0	1	0	0	0	9579	1635	57	5	1316	5	MIDN	19	1257154	Missense_Mutation	SNP	T	TCGA-76-6285-01A-11D-1696-08		1257154	57871829	54	19545											
ZNF492	57615	broad.mit.edu	37	chr19	22846866	22846866	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcaaattcaaacagacataCgataagacatactggaaaga	6	7	2	3			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr19:22846866C>T	uc002nqw.3	+	4	639	c.395C>T	c.(394-396)ACG>ATG	p.T132M		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AACAGACATACGATAAGACAT	0.308													T	22846866	T	T	22846866	3	4	272	1	0	0	0	0	1	0	0	0	17940	536	19	1	405	1	ZNF492	19	22846866	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	21589712	22846866	36282117	55	19546											
LTBP4	8425	broad.mit.edu	37	chr19	41129963	41129963	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	atggctcgcagcgccgctgcGtctccaacgagagccagagc	13	15	1	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr19:41129963G>C	uc002ooh.1	+	30	4009	c.4009G>C	c.(4009-4011)GTC>CTC	p.V1337L	LTBP4_uc002oog.1_Missense_Mutation_p.V1300L|LTBP4_uc002ooi.1_Missense_Mutation_p.V1270L|LTBP4_uc002ooj.1_Missense_Mutation_p.V210L|LTBP4_uc002ook.1_Missense_Mutation_p.V471L|LTBP4_uc002ool.1_Missense_Mutation_p.V349L|LTBP4_uc010xvp.1_Missense_Mutation_p.V97L	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1337	EGF-like 14; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCGCCGCTGCGTCTCCAACGA	0.682													C	41129963	C	C	41129963	3	2	272	1	0	0	0	0	1	0	0	0	9076	1145	40	5	4415	5	LTBP4	19	41129963	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	18283097	41129963	17999020	56	19547											
TGM3	7053	broad.mit.edu	37	chr20	2298127	2298127	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggacaagggtagtgatagcGtatggtaagtatctcacctt	12	6	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr20:2298127G>A	uc002wfx.3	+	7	1076	c.979G>A	c.(979-981)GTA>ATA	p.V327I		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	327					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	TAGTGATAGCGTATGGTAAGT	0.507													A	2298127	A	A	2298127	3	1	272	1	0	0	0	0	1	0	0	0	15828	1145	40	1	1005	1	TGM3	20	2298127	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08		2298127	60727393	57	19548											
CRNKL1	51340	broad.mit.edu	37	chr20	20033098	20033098	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacaaacaggatctcggaacCggaagcggaacttgcaggac	12	10	1	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr20:20033098C>T	uc002wrs.2	-	2	404	c.372G>A	c.(370-372)CCG>CCA	p.P124P	C20orf26_uc010gcw.1_5'Flank|C20orf26_uc010zse.1_5'Flank|C20orf26_uc002wru.2_5'Flank|CRNKL1_uc002wrt.1_Silent_p.P112P	NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	124					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						ATCTCGGAACCGGAAGCGGAA	0.592													T	20033098	T	T	20033098	2	4	272	1	0	0	0	0	0	0	0	1	3891	639	23	2		2	CRNKL1	20	20033098	Silent	SNP	C	TCGA-76-6285-01A-11D-1696-08	17734971	20033098	42992422	58	19549											
CD93	22918	broad.mit.edu	37	chr20	23065129	23065129	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgttgttttgtgtggccacGgaggagtccccacctgcagg	14	11	0	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr20:23065129G>A	uc002wsv.2	-	1	1849	c.1701C>T	c.(1699-1701)TCC>TCT	p.S567S		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	567	Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GTGTGGCCACGGAGGAGTCCC	0.637													A	23065129	A	A	23065129	2	1	272	1	0	0	0	0	0	0	0	1	3047	1103	39	2		2	CD93	20	23065129	Silent	SNP	G	TCGA-76-6285-01A-11D-1696-08	3032031	23065129	39960391	59	19550											
BPIL1	80341	broad.mit.edu	37	chr20	31596448	31596448	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtggtcggtgcctccacgcCaggcaccgtggtccgactca	13	16	1	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr20:31596448C>T	uc002wyj.2	+	2	262	c.68C>T	c.(67-69)CCA>CTA	p.P23L		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	23						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						GCCTCCACGCCAGGCACCGTG	0.622													T	31596448	T	T	31596448	3	4	272	1	0	0	0	0	1	0	0	0	1491	594	21	3	70	3	BPIL1	20	31596448	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	8531319	31596448	31429072	60	19551											
PREX1	57580	broad.mit.edu	37	chr20	47262489	47262489	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatgcccccatggtcactccTgtccatctcgctctcttcac	6	18	4	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr20:47262489T>C	uc002xtw.1	-	26	3435	c.3412A>G	c.(3412-3414)AGG>GGG	p.R1138G	PREX1_uc002xtv.1_Missense_Mutation_p.R435G	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1138					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			TGGTCACTCCTGTCCATCTCG	0.617													C	47262489	C	C	47262489	3	2	272	1	0	0	0	0	1	0	0	0	12476	1579	55	4	1627	4	PREX1	20	47262489	Missense_Mutation	SNP	T	TCGA-76-6285-01A-11D-1696-08	15666041	47262489	15763031	61	19552											
PRIC285	85441	broad.mit.edu	37	chr20	62197056	62197056	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagcagccgctcctgccGcacaggccccgggcaccacg	12	20	0	0			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr20:62197056G>A	uc002yfm.2	-	9	4011	c.3119C>T	c.(3118-3120)GCG>GTG	p.A1040V	PRIC285_uc002yfl.1_Missense_Mutation_p.A471V	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1040	Ala-rich.				cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CGCTCCTGCCGCACAGGCCCC	0.687													A	62197056	A	A	62197056	3	1	272	1	0	0	0	0	1	0	0	0	12485	1087	38	1	4878	1	PRIC285	20	62197056	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08	14934567	62197056	828464	62	19553											
IL17RA	23765	broad.mit.edu	37	chr22	17586805	17586805	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatcctgctggtgggctccGtcatcctgctcatcgtctgc	10	16	3	0	rs138404135		TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr22:17586805G>A	uc002zly.2	+	11	1139	c.1006G>A	c.(1006-1008)GTC>ATC	p.V336I	IL17RA_uc010gqt.2_Intron	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	336	Helical; (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		GGTGGGCTCCGTCATCCTGCT	0.423													A	17586805	A	A	17586805	3	1	272	1	0	0	0	0	1	0	0	0	7639	1145	40	1	1048	1	IL17RA	22	17586805	Missense_Mutation	SNP	G	TCGA-76-6285-01A-11D-1696-08		17586805	33717761	63	19554											
MYO18B	84700	broad.mit.edu	37	chr22	26159232	26159232	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caagagccctccaccatcctCgccccctcctcttttctctg	4	21	2	1	rs79294358	by1000genomes	TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr22:26159232C>T	uc003abz.1	+	3	324	c.74C>T	c.(73-75)TCG>TTG	p.S25L	MYO18B_uc003aca.1_5'UTR|MYO18B_uc010guy.1_5'UTR|MYO18B_uc010guz.1_5'UTR|MYO18B_uc011aka.1_5'UTR	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	25						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CCACCATCCTCGCCCCCTCCT	0.542													T	26159232	T	T	26159232	3	4	272	1	0	0	0	0	1	0	0	0	10066	893	31	2	80	2	MYO18B	22	26159232	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	8572427	26159232	25145334	64	19555											
FAM109B	150368	broad.mit.edu	37	chr22	42473575	42473575	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctttgccatctgctttgatgCccctggagtgcgcccacacc	9	16	1	1			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chr22:42473575C>G	uc003bbz.2	+	3	465	c.278C>G	c.(277-279)GCC>GGC	p.A93G	C22orf32_uc003bca.2_5'Flank	NM_001002034	NP_001002034	Q6ICB4	SESQ2_HUMAN	hypothetical protein LOC150368	93	PH.				endosome organization|receptor recycling|retrograde transport, endosome to Golgi	clathrin-coated vesicle|early endosome|recycling endosome|trans-Golgi network	protein homodimerization activity				0						TGCTTTGATGCCCCTGGAGTG	0.682													G	42473575	G	G	42473575	3	3	272	1	0	0	0	0	1	0	0	0	5395	739	26	5	280	5	FAM109B	22	42473575	Missense_Mutation	SNP	C	TCGA-76-6285-01A-11D-1696-08	16314343	42473575	8830991	65	19556											
USP51	158880	broad.mit.edu	37	chrX	55514642	55514642	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agagacaagagtggagtctgTtcatatgggtactacatacg	12	6	2	2			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chrX:55514642T>C	uc004dun.1	-	2	810	c.731A>G	c.(730-732)AAC>AGC	p.N244S	USP51_uc011moo.1_Intron	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	244	UBP-type.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						GTGGAGTCTGTTCATATGGGT	0.448													C	55514642	C	C	55514642	3	2	272	1	0	0	0	0	1	0	0	0	17080	1725	60	4	1408	4	USP51	23	55514642	Missense_Mutation	SNP	T	TCGA-76-6285-01A-11D-1696-08		55514642	99755918	66	19557											
POF1B	79983	broad.mit.edu	37	chrX	84562214	84562214	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgatgccaagagttcttcGtactcttttaattgagtgtc	8	8	2	3			TCGA-76-6285-01A-11D-1696-08	TCGA-76-6285-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	28380a2f-d302-45fb-a4c5-31b2fd150bc3	6a1d3a89-3c8f-4a02-ae9a-870918116abf	g.chrX:84562214G>A	uc004eer.2	-	11	1265	c.1119C>T	c.(1117-1119)TAC>TAT	p.Y373Y	POF1B_uc004ees.2_Silent_p.Y373Y	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	373	Potential.						actin binding				0						AGAGTTCTTCGTACTCTTTTA	0.333													A	84562214	A	A	84562214	2	1	272	1	0	0	0	0	0	0	0	1	12182	1140	40	1		1	POF1B	23	84562214	Silent	SNP	G	TCGA-76-6285-01A-11D-1696-08	29047572	84562214	70708346	67	19558											
TTC4	7268	broad.mit.edu	37	chr1	55207175	55207175	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tccgggggagaaaggtgtacCagatacgatgactaagccag	14	8	0	3			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr1:55207175C>G	uc001cxx.3	+	10	1206	c.1153C>G	c.(1153-1155)CAG>GAG	p.Q385E	C1orf175_uc001cxq.2_RNA|TTC4_uc001cxw.3_Missense_Mutation_p.Q286E|TTC4_uc001cxv.2_Missense_Mutation_p.Q396E	NM_004623	NP_004614	O95801	TTC4_HUMAN	tetratricopeptide repeat domain 4	385							binding				0						AAAGGTGTACCAGATACGATG	0.517													G	55207175	G	G	55207175	3	3	273	1	0	0	0	0	1	0	0	0	16707	595	21	5	1191	5	TTC4	1	55207175	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08		55207175	194043446	1	19559											
RPE65	6121	broad.mit.edu	37	chr1	68905261	68905261	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tacctatgaacgtaagatggCttgaatcggtcactgcaggg	12	8	1	3			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr1:68905261C>A	uc001dei.1	-	7	762	c.708G>T	c.(706-708)AAG>AAT	p.K236N		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	236					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						CGTAAGATGGCTTGAATCGGT	0.403													A	68905261	A	A	68905261	3	1	273	1	0	0	0	0	1	0	0	0	13545	796	28	5	925	5	RPE65	1	68905261	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	13698086	68905261	180345360	2	19560											
RPRD2	23248	broad.mit.edu	37	chr1	150437160	150437160	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	accccagagagcattctgtcTgcactttccaaaacccagac	6	15	2	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr1:150437160T>A	uc009wlr.2	+	10	1770	c.1569T>A	c.(1567-1569)TCT>TCA	p.S523S	RPRD2_uc010pcc.1_Silent_p.S497S|RPRD2_uc001eup.3_Silent_p.S497S	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	523	Ser-rich.						protein binding			ovary(1)	1						GCATTCTGTCTGCACTTTCCA	0.502											OREG0013786	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	150437160	A	A	150437160	2	1	273	1	0	0	0	0	0	0	0	1	13617	1567	55	5		5	RPRD2	1	150437160	Silent	SNP	T	TCGA-76-6286-01A-11D-1845-08	81531899	150437160	98813461	3	19561											
SLC9A11	284525	broad.mit.edu	37	chr1	173526582	173526582	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	accacgtgattacaactcccCatcgccaattatattcataa	3	13	1	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr1:173526582C>G	uc001giz.2	-	10	1535	c.1112G>C	c.(1111-1113)TGG>TCG	p.W371S	SLC9A11_uc009wwe.2_5'UTR|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	371					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TACAACTCCCCATCGCCAATT	0.368													G	173526582	G	G	173526582	3	3	273	1	0	0	0	0	1	0	0	0	14711	595	21	5	2338	5	SLC9A11	1	173526582	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	23089422	173526582	75724039	4	19562											
RYR2	6262	broad.mit.edu	37	chr1	237791219	237791219	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgctccatcggcagtatgaCggcattgggggtcttgttcg	14	9	1	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr1:237791219C>T	uc001hyl.1	+	41	6399	c.6279C>T	c.(6277-6279)GAC>GAT	p.D2093D		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2093	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCAGTATGACGGCATTGGGG	0.552													T	237791219	T	T	237791219	2	4	273	1	0	0	0	0	0	0	0	1	13769	535	19	1		1	RYR2	1	237791219	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08	64264637	237791219	11459402	5	19563											
TTC7A	57217	broad.mit.edu	37	chr2	47206005	47206005	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gagctcacctacttcctggaAgctgccctccagagcgccta	9	16	1	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr2:47206005A>G	uc002rvo.2	+	5	1091	c.723A>G	c.(721-723)GAA>GAG	p.E241E	TTC7A_uc002rvm.2_Silent_p.E207E|TTC7A_uc002rvn.1_Silent_p.E122E|TTC7A_uc010fbb.2_Silent_p.E241E|TTC7A_uc010fbc.2_5'UTR|TTC7A_uc002rvp.2_Silent_p.E122E|TTC7A_uc002rvq.2_5'UTR	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	241							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			ACTTCCTGGAAGCTGCCCTCC	0.537													G	47206005	G	G	47206005	2	3	273	1	0	0	0	0	0	0	0	1	16709	69	3	4		4	TTC7A	2	47206005	Silent	SNP	A	TCGA-76-6286-01A-11D-1845-08		47206005	195993368	6	19564											
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48809567	48809567	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctctgaaagctaaaatgaacCgccgagcatgtctggggagt	12	9	2	2	rs147440328		TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr2:48809567C>T	uc010yol.1	+	1	1842	c.1795C>T	c.(1795-1797)CGC>TGC	p.R599C	STON1_uc002rwo.3_Missense_Mutation_p.R599C|STON1_uc010fbm.2_Missense_Mutation_p.R599C|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.R599C|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.R599C	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	599					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TAAAATGAACCGCCGAGCATG	0.483													T	48809567	T	T	48809567	3	4	273	1	0	0	0	0	1	0	0	0	15316	652	23	2	1797	2	STON1-GTF2A1L	2	48809567	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	1603562	48809567	194389806	7	19565											
EDAR	10913	broad.mit.edu	37	chr2	109522815	109522815	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcgaggatctttttcctccGgctttgaatctgtgaaaaag	9	8	2	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr2:109522815G>A	uc002teq.3	-	11	1404	c.973C>T	c.(973-975)CGG>TGG	p.R325W	EDAR_uc010fjn.2_Missense_Mutation_p.R357W|EDAR_uc010yws.1_Missense_Mutation_p.R357W	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	325	Cytoplasmic (Potential).				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1						TTTTTCCTCCGGCTTTGAATC	0.512													A	109522815	A	A	109522815	3	1	273	1	0	0	0	0	1	0	0	0	4905	1115	39	2	381	2	EDAR	2	109522815	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	60713248	109522815	133676558	8	19566											
CNTNAP5	129684	broad.mit.edu	37	chr2	125504853	125504853	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ggcggtccaatgaaaggcacCcttactggggaggttcccct	13	12	0	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr2:125504853C>A	uc002tno.2	+	14	2486	c.2122C>A	c.(2122-2124)CCT>ACT	p.P708T	CNTNAP5_uc010flu.2_Missense_Mutation_p.P709T	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	708	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGAAAGGCACCCTTACTGGGG	0.537													A	125504853	A	A	125504853	3	1	273	1	0	0	0	0	1	0	0	0	3650	623	22	5	2176	5	CNTNAP5	2	125504853	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	15982038	125504853	117694520	9	19567											
POTEE	445582	broad.mit.edu	37	chr2	131984443	131984443	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtacatgagcaaaaacagcaAgtcgtgaaatttttaatcaa	7	6	1	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr2:131984443A>G	uc002tsn.2	+	4	910	c.858A>G	c.(856-858)CAA>CAG	p.Q286Q	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	286	ANK 4.						ATP binding				0						AAAAACAGCAAGTCGTGAAAT	0.333													G	131984443	G	G	131984443	2	3	273	1	0	0	0	0	0	0	0	1	12264	69	3	4		4	POTEE	2	131984443	Silent	SNP	A	TCGA-76-6286-01A-11D-1845-08	6479590	131984443	111214930	10	19568											
ZNF804A	91752	broad.mit.edu	37	chr2	185731110	185731110	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tttcaggactatgctgagaaGgaaaataccatagcaaaagc	9	7	1	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr2:185731110G>C	uc002uph.2	+	2	720	c.126G>C	c.(124-126)AAG>AAC	p.K42N		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	42						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						ATGCTGAGAAGGAAAATACCA	0.363													C	185731110	C	C	185731110	3	2	273	1	0	0	0	0	1	0	0	0	18167	991	35	5	132	5	ZNF804A	2	185731110	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	53746667	185731110	57468263	11	19569											
MPP4	58538	broad.mit.edu	37	chr2	202552079	202552079	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggggaagtaggggtttcacGtaataactccactacctggt	12	8	1	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr2:202552079G>A	uc002uyk.3	-	5	503	c.295C>T	c.(295-297)CGT>TGT	p.R99C	MPP4_uc010ftj.2_Missense_Mutation_p.R99C|MPP4_uc010zhq.1_Missense_Mutation_p.R99C|MPP4_uc010zhr.1_Missense_Mutation_p.R99C|MPP4_uc010zhs.1_Missense_Mutation_p.R99C|MPP4_uc002uyj.3_Missense_Mutation_p.R99C|MPP4_uc010zht.1_Intron|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Missense_Mutation_p.R99C|MPP4_uc002uym.1_Missense_Mutation_p.R112C|MPP4_uc002uyn.2_Missense_Mutation_p.R99C	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	99	L27 2.					cytoplasm	protein binding				0						GGGGTTTCACGTAATAACTCC	0.408													A	202552079	A	A	202552079	3	1	273	1	0	0	0	0	1	0	0	0	9736	1145	40	1	1690	1	MPP4	2	202552079	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	16820969	202552079	40647294	12	19570											
SHISA5	51246	broad.mit.edu	37	chr3	48520627	48520627	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagggcgaaacctcagcgcCgagcccagctgctccaccgg	12	18	1	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr3:48520627C>T	uc003ctp.1	-	3	407	c.273G>A	c.(271-273)TCG>TCA	p.S91S	SHISA5_uc003cto.1_Silent_p.S60S|SHISA5_uc003ctq.1_Silent_p.S84S|SHISA5_uc003ctr.1_Silent_p.S60S|SHISA5_uc003cts.1_Silent_p.S60S|SHISA5_uc011bbl.1_5'UTR	NM_016479	NP_057563	Q8N114	SHSA5_HUMAN	scotin precursor	91	Extracellular (Potential).				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	signal transducer activity|WW domain binding				0						ACCTCAGCGCCGAGCCCAGCT	0.592													T	48520627	T	T	48520627	2	4	273	1	0	0	0	0	0	0	0	1	14283	639	23	2		2	SHISA5	3	48520627	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08		48520627	149501803	13	19571											
CACNA2D2	9254	broad.mit.edu	37	chr3	50513588	50513588	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctccaaaaatccgcatcacGccgtcgacctcctgctccag	6	19	1	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr3:50513588G>A	uc003daq.2	-	2	287	c.249C>T	c.(247-249)GGC>GGT	p.G83G	CACNA2D2_uc003dap.2_Silent_p.G83G	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	83	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TCCGCATCACGCCGTCGACCT	0.632													A	50513588	A	A	50513588	2	1	273	1	0	0	0	0	0	0	0	1	2549	1074	38	1		1	CACNA2D2	3	50513588	Silent	SNP	G	TCGA-76-6286-01A-11D-1845-08	1992961	50513588	147508842	14	19572											
PIK3CA	5290	broad.mit.edu	37	chr3	178916726	178916726	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgactttagaatgcctccGtgaggctacattaataacca	8	9	0	3			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr3:178916726G>A	uc003fjk.2	+	2	270	c.113G>A	c.(112-114)CGT>CAT	p.R38H		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	38	PI3K-ABD.		R -> H (in cancer; shows an increase in lipid kinase activity; may disrupt the interaction between the PI3K-ABD domain and the N-terminal lobe of PI3K/PI4K kinase domain possibly affecting the conformation of the kinase domain).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R38H(4)|p.R38S(1)|p.R38G(1)|p.R38C(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAATGCCTCCGTGAGGCTACA	0.393		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			A	178916726	A	A	178916726	3	1	273	1	0	0	0	0	1	0	0	0	11913	1145	40	1	115	1	PIK3CA	3	178916726	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	128403138	178916726	19105704	15	19573											
PF4V1	5197	broad.mit.edu	37	chr4	74719597	74719597	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcctggaggtgatcaaggcCggaccccactgccccactgc	12	16	1	1	rs147144357		TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr4:74719597C>T	uc003hhg.1	+	2	265	c.198C>T	c.(196-198)GCC>GCT	p.A66A		NM_002620	NP_002611	P10720	PF4V_HUMAN	platelet factor 4 variant 1	66					immune response	extracellular region	chemokine activity|heparin binding				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TGATCAAGGCCGGACCCCACT	0.607													T	74719597	T	T	74719597	2	4	273	1	0	0	0	0	0	0	0	1	11753	639	23	2		2	PF4V1	4	74719597	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08		74719597	116434679	16	19574											
TACR3	6870	broad.mit.edu	37	chr4	104579420	104579420	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	attgcacaaagcagagagtaCggcctggcatgactttggtt	12	8	0	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr4:104579420C>T	uc003hxe.1	-	2	832	c.689G>A	c.(688-690)CGT>CAT	p.R230H		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	230	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GCAGAGAGTACGGCCTGGCAT	0.393													T	104579420	T	T	104579420	3	4	273	1	0	0	0	0	1	0	0	0	15504	536	19	1	724	1	TACR3	4	104579420	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	29859823	104579420	86574856	17	19575											
ZNF827	152485	broad.mit.edu	37	chr4	146697085	146697085	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcacttagcagcataggggCacaagtggcatttgtatttt	12	7	0	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr4:146697085C>T	uc003ikn.2	-	10	2597	c.2549G>A	c.(2548-2550)TGC>TAC	p.C850Y	ZNF827_uc003ikm.2_Missense_Mutation_p.C850Y|ZNF827_uc010iox.2_Missense_Mutation_p.C500Y|ZNF827_uc003ikl.2_5'UTR	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	850	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					AGCATAGGGGCACAAGTGGCA	0.498													T	146697085	T	T	146697085	3	4	273	1	0	0	0	0	1	0	0	0	18177	710	25	3	700	3	ZNF827	4	146697085	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	42117665	146697085	44457191	18	19576											
ODZ3	55714	broad.mit.edu	37	chr4	183651467	183651467	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tatactattacccgccaggaCggaatgtgagttagtcccat	9	10	0	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr4:183651467C>T	uc003ivd.1	+	14	2737	c.2700C>T	c.(2698-2700)GAC>GAT	p.D900D	ODZ3_uc003ive.1_Silent_p.D306D	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	900	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CCCGCCAGGACGGAATGTGAG	0.398													T	183651467	T	T	183651467	2	4	273	1	0	0	0	0	0	0	0	1	10836	535	19	1		1	ODZ3	4	183651467	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08	36954382	183651467	7502809	19	19577											
FCHO2	115548	broad.mit.edu	37	chr5	72383422	72383422	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcttttctttgtaggttctgGgtccctccgagcaaaatttg	9	9	3	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr5:72383422G>A	uc003kcl.2	+	25	2368	c.2252G>A	c.(2251-2253)GGG>GAG	p.G751E	FCHO2_uc011csl.1_Missense_Mutation_p.G718E|FCHO2_uc010izb.2_Missense_Mutation_p.G179E|FCHO2_uc011csn.1_Missense_Mutation_p.G179E	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2 isoform a	751										ovary(1)	1		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		GTAGGTTCTGGGTCCCTCCGA	0.398													A	72383422	A	A	72383422	3	1	273	1	0	0	0	0	1	0	0	0	5788	1232	43	3	2350	3	FCHO2	5	72383422	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08		72383422	108531838	20	19578											
GABRA6	2559	broad.mit.edu	37	chr5	161119060	161119060	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagctgtttgctttgcattcGtcttctctgcgcttatcgag	9	10	2	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr5:161119060G>A	uc003lyu.2	+	8	1278	c.940G>A	c.(940-942)GTC>ATC	p.V314I	GABRA6_uc003lyv.2_Missense_Mutation_p.V85I	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	314	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity	p.V314I(1)		ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTTTGCATTCGTCTTCTCTGC	0.478										TCGA Ovarian(5;0.080)			A	161119060	A	A	161119060	3	1	273	1	0	0	0	0	1	0	0	0	6165	1145	40	1	970	1	GABRA6	5	161119060	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	88735638	161119060	19796200	21	19579											
LRRC16A	55604	broad.mit.edu	37	chr6	25450163	25450163	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctccatggagccatctgagCgcctggctagtctccaggcg	12	14	3	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr6:25450163C>T	uc011djw.1	+	6	785	c.409C>T	c.(409-411)CGC>TGC	p.R137C	LRRC16A_uc010jpx.2_Missense_Mutation_p.R137C|LRRC16A_uc010jpy.2_Missense_Mutation_p.R137C|LRRC16A_uc003nez.1_5'Flank	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	137					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						GCCATCTGAGCGCCTGGCTAG	0.468													T	25450163	T	T	25450163	3	4	273	1	0	0	0	0	1	0	0	0	8971	768	27	1	431	1	LRRC16A	6	25450163	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08		25450163	145664904	22	19580											
ABCF1	23	broad.mit.edu	37	chr6	30548286	30548286	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agggaaggagaaggccaagaAggcagagcaggtgtgtattt	17	4	0	3			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr6:30548286A>G	uc003nql.2	+	8	763	c.668A>G	c.(667-669)AAG>AGG	p.K223R	ABCF1_uc003nqk.2_Missense_Mutation_p.K224R|ABCF1_uc003nqm.2_Missense_Mutation_p.K223R|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	223	Glu-rich.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						AAGGCCAAGAAGGCAGAGCAG	0.453													G	30548286	G	G	30548286	3	3	273	1	0	0	0	0	1	0	0	0	65	72	3	4	698	4	ABCF1	6	30548286	Missense_Mutation	SNP	A	TCGA-76-6286-01A-11D-1845-08	5098123	30548286	140566781	23	19581											
CYP21A2	1589	broad.mit.edu	37	chr6	31973481	31973483	+	In_Frame_Del	DEL	CTG	-	-													ttgccatgctgctcctgggcCtgctgctgctgctgcccctg							TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr6:31973481_31973483delCTG	uc010jtp.2	+	1	134_136	c.16_18delCTG	c.(16-18)CTGdel	p.L10del	CYP21A2_uc011dpb.1_In_Frame_Del_p.L10del			P08686	CP21A_HUMAN	SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2; SubName: Full=Cytochrome P450 21-hydroxylase; SubName: Full=Cytochrome P450, family 21, subfamily A, polypeptide 2, isoform CRA_b; SubName: Full=DJ34F7.3 (Cytochrome P450, subfamily XXIA (Steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 (CYP21, P450c21B)); SubName: Full=cDNA, FLJ95495, Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 2(CYP21A2), mRNA;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						gctcctgggcctgctgctgctgc	0.527													-	31973483	-	-	31973481	7	5	273	1	0	1	0	1	0	0	0	0	4153	680	24	0	18	0	CYP21A2	6	31973481	In_Frame_Del	DEL	CTG	TCGA-76-6286-01A-11D-1845-08	1425195	31973481	139141586	24	19582											
ZDHHC4	55146	broad.mit.edu	37	chr7	6628405	6628405	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgactgggcctggtgccagcGttgtccccttgtggcctggc	15	13	0	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr7:6628405G>A	uc003sqi.2	+	9	1257	c.899G>A	c.(898-900)CGT>CAT	p.R300H	ZDHHC4_uc003sql.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqh.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqj.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqk.2_Missense_Mutation_p.R300H|ZDHHC4_uc003sqm.2_Missense_Mutation_p.R300H|uc011jwy.1_5'Flank|C7orf26_uc003sqo.1_5'Flank|C7orf26_uc003sqp.1_5'Flank|C7orf26_uc003sqq.1_5'Flank	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	300						integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		TGGTGCCAGCGTTGTCCCCTT	0.577													A	6628405	A	A	6628405	3	1	273	1	0	0	0	0	1	0	0	0	17614	1145	40	1	921	1	ZDHHC4	7	6628405	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08		6628405	152510258	25	19583											
PCLO	27445	broad.mit.edu	37	chr7	82583736	82583736	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgagagaaggtgtgtcagagGgtgggacagatgtagcactt	17	4	1	4			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr7:82583736G>T	uc003uhx.2	-	5	6822	c.6533C>A	c.(6532-6534)CCC>CAC	p.P2178H	PCLO_uc003uhv.2_Missense_Mutation_p.P2178H|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2109					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGTGTCAGAGGGTGGGACAGA	0.428													T	82583736	T	T	82583736	3	4	273	1	0	0	0	0	1	0	0	0	11583	1232	43	5	8996	5	PCLO	7	82583736	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	75955331	82583736	76554927	26	19584											
MUC17	140453	broad.mit.edu	37	chr7	100684314	100684314	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgaagccacttcatctacaaCtgctgaaggtaccagcattc	7	12	2	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr7:100684314C>G	uc003uxp.1	+	3	9670	c.9617C>G	c.(9616-9618)ACT>AGT	p.T3206S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3206	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|52.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCATCTACAACTGCTGAAGGT	0.502													G	100684314	G	G	100684314	3	3	273	1	0	0	0	0	1	0	0	0	9974	565	20	5	9627	5	MUC17	7	100684314	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	18100578	100684314	58454349	27	19585											
EZH2	2146	broad.mit.edu	37	chr7	148529726	148529726	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagatatcttatttacatacCataaaattctgctgtagggg	7	6	2	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr7:148529726C>G	uc003wfd.1	-	4	529	c.363G>C	c.(361-363)ATG>ATC	p.M121I	EZH2_uc011kug.1_Missense_Mutation_p.M112I|EZH2_uc003wfb.1_Missense_Mutation_p.M121I|EZH2_uc003wfc.1_Intron|EZH2_uc011kuh.1_Missense_Mutation_p.M112I|EZH2_uc011kui.1_Missense_Mutation_p.M121I|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	121	Interaction with DNMT1, DNMT3A and DNMT3B.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			ATTTACATACCATAAAATTCT	0.313			Mis		DLBCL								G	148529726	G	G	148529726	3	3	273	1	0	0	0	0	1	0	0	0	5334	608	21	5	1960	5	EZH2	7	148529726	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	47845412	148529726	10608937	28	19586											
TNFRSF10C	8794	broad.mit.edu	37	chr8	22972207	22972207	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catactggagcctgtaacccGtgcacagagggtgtggatta	13	9	0	1	rs74480765	byFrequency	TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr8:22972207G>A	uc003xcy.2	+	3	405	c.204G>A	c.(202-204)CCG>CCA	p.P68P	TNFRSF10C_uc011kzr.1_RNA	NM_003841	NP_003832	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily,	68					apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		CCTGTAACCCGTGCACAGAGG	0.468													A	22972207	A	A	22972207	2	1	273	1	0	0	0	0	0	0	0	1	16279	1132	40	1		1	TNFRSF10C	8	22972207	Silent	SNP	G	TCGA-76-6286-01A-11D-1845-08		22972207	123391815	29	19587											
SLCO5A1	81796	broad.mit.edu	37	chr8	70617355	70617355	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaacatagtaaagacacaccActgcagatcattgctagttt	6	9	1	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr8:70617355A>G	uc003xyl.2	-	6	2240	c.1533T>C	c.(1531-1533)AGT>AGC	p.S511S	SLCO5A1_uc010lzb.2_Silent_p.S456S|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Silent_p.S511S|SLCO5A1_uc010lzc.2_Silent_p.S456S	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	511	Helical; Name=9; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			AAGACACACCACTGCAGATCA	0.408													G	70617355	G	G	70617355	2	3	273	1	0	0	0	0	0	0	0	1	14731	156	6	4		4	SLCO5A1	8	70617355	Silent	SNP	A	TCGA-76-6286-01A-11D-1845-08	47645148	70617355	75746667	30	19588											
RIMS2	9699	broad.mit.edu	37	chr8	104897848	104897848	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagtgatccgaatttggccCgttatccagtaaagccacaa	9	10	0	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr8:104897848C>T	uc003yls.2	+	2	596	c.355C>T	c.(355-357)CGT>TGT	p.R119C	RIMS2_uc003ylp.2_Missense_Mutation_p.R341C|RIMS2_uc003ylw.2_Missense_Mutation_p.R149C|RIMS2_uc003ylq.2_Missense_Mutation_p.R149C|RIMS2_uc003ylr.2_Missense_Mutation_p.R149C	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	372					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAATTTGGCCCGTTATCCAGT	0.473										HNSCC(12;0.0054)			T	104897848	T	T	104897848	3	4	273	1	0	0	0	0	1	0	0	0	13368	652	23	2	1161	2	RIMS2	8	104897848	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	34280493	104897848	41466174	31	19589											
CNTLN	54875	broad.mit.edu	37	chr9	17330744	17330744	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atgaaaaactgtcagaaaacAtatctgccaacaagggtttc	7	8	2	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr9:17330744A>G	uc003zmz.2	+	9	1482	c.1456A>G	c.(1456-1458)ATA>GTA	p.I486V	CNTLN_uc003zmy.2_Missense_Mutation_p.I486V|CNTLN_uc010mio.2_Missense_Mutation_p.I165V	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	486						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		GTCAGAAAACATATCTGCCAA	0.368													G	17330744	G	G	17330744	3	3	273	1	0	0	0	0	1	0	0	0	3639	217	8	4	1520	4	CNTLN	9	17330744	Missense_Mutation	SNP	A	TCGA-76-6286-01A-11D-1845-08		17330744	123882687	32	19590											
FBXO10	26267	broad.mit.edu	37	chr9	37515999	37515999	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ctggttttgccctggaagatGatgttttcctgcaccagggc	12	10	0	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr9:37515999G>T	uc004aab.2	-	10	2647	c.2598C>A	c.(2596-2598)ATC>ATA	p.I866I	FBXO10_uc004aac.2_Silent_p.I882I|FBXO10_uc004aad.2_Silent_p.I416I	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	866						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		CCTGGAAGATGATGTTTTCCT	0.522													T	37515999	T	T	37515999	2	4	273	1	0	0	0	0	0	0	0	1	5726	1280	45	5		5	FBXO10	9	37515999	Silent	SNP	G	TCGA-76-6286-01A-11D-1845-08	20185255	37515999	103697432	33	19591											
TMC1	117531	broad.mit.edu	37	chr9	75435855	75435855	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggccgttatgtgctgcaatGttcctgaggccagggtcttc	14	10	1	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr9:75435855G>A	uc004aiz.1	+	20	2401	c.1861G>A	c.(1861-1863)GTT>ATT	p.V621I	TMC1_uc010moz.1_Missense_Mutation_p.V579I|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.V475I|TMC1_uc010mpa.1_Missense_Mutation_p.V475I	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	621	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						GTGCTGCAATGTTCCTGAGGC	0.502													A	75435855	A	A	75435855	3	1	273	1	0	0	0	0	1	0	0	0	15981	1377	48	3	1923	3	TMC1	9	75435855	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	37919856	75435855	65777576	34	19592											
ASTN2	23245	broad.mit.edu	37	chr9	119770488	119770488	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggaaagcttggccgggtttaAccagtcggagatgtccaggt	15	8	0	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr9:119770488A>G	uc004bjs.1	-	7	1575	c.1474T>C	c.(1474-1476)TTA>CTA	p.L492L	ASTN2_uc004bjr.1_Silent_p.L492L|ASTN2_uc004bjt.1_Silent_p.L441L	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	492	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GCCGGGTTTAACCAGTCGGAG	0.512													G	119770488	G	G	119770488	2	3	273	1	0	0	0	0	0	0	0	1	1065	40	2	4		4	ASTN2	9	119770488	Silent	SNP	A	TCGA-76-6286-01A-11D-1845-08	44334633	119770488	21442943	35	19593											
GPSM1	26086	broad.mit.edu	37	chr9	139250804	139250804	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccccccgcagcccagccctcGatgacggcctcgccccagac	9	23	0	2	rs79557901	byFrequency	TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr9:139250804G>A	uc004chd.2	+	13	1843	c.1623G>A	c.(1621-1623)TCG>TCA	p.S541S	GPSM1_uc011mdu.1_Silent_p.S32S|GPSM1_uc004che.2_Silent_p.S32S	NM_001145638	NP_001139110	Q86YR5	GPSM1_HUMAN	G-protein signaling modulator 1 (AGS3-like, C.	541					cell differentiation|nervous system development|signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|plasma membrane	binding|GTPase activator activity				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.39e-06)|Epithelial(140;3.24e-06)		CCCAGCCCTCGATGACGGCCT	0.716													A	139250804	A	A	139250804	2	1	273	1	0	0	0	0	0	0	0	1	6734	1045	37	2		2	GPSM1	9	139250804	Silent	SNP	G	TCGA-76-6286-01A-11D-1845-08	19480316	139250804	1962627	36	19594											
KIAA0913	23053	broad.mit.edu	37	chr10	75556970	75556970	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcttggcacttggcagtcGtggaggctataatggacggg	16	9	0	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr10:75556970G>A	uc009xrl.2	+	17	3391	c.3359G>A	c.(3358-3360)CGT>CAT	p.R1120H	KIAA0913_uc001jve.2_Missense_Mutation_p.R1125H|KIAA0913_uc001jvf.2_Missense_Mutation_p.R1120H|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.R555H|KIAA0913_uc010qkr.1_Missense_Mutation_p.R543H|KIAA0913_uc001jvj.2_Missense_Mutation_p.R543H|KIAA0913_uc009xrn.1_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	1120							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					CTTGGCAGTCGTGGAGGCTAT	0.577													A	75556970	A	A	75556970	3	1	273	1	0	0	0	0	1	0	0	0	8200	1145	40	1	3440	1	KIAA0913	10	75556970	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08		75556970	59977777	37	19595											
PTEN	5728	broad.mit.edu	37	chr10	89720661	89720661	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttttttaggacaaaatgtTtcacttttgggtaaatacat	6	4	1	0	rs142420551		TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr10:89720661T>C	uc001kfb.2	+	9	1843	c.812T>C	c.(811-813)TTT>TCT	p.F271S		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	271	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.F271S(2)|p.D268_F279>VGQNVSLLGKYI(2)|p.F271fs*5(1)|p.G165_*404del(1)|p.F271L(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GACAAAATGTTTCACTTTTGG	0.249		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89720661	C	C	89720661	3	2	273	1	0	0	0	0	1	0	0	0	12738	1841	64	4	842	4	PTEN	10	89720661	Missense_Mutation	SNP	T	TCGA-76-6286-01A-11D-1845-08	14163691	89720661	45814086	38	19596											
MUC5B	727897	broad.mit.edu	37	chr11	1273709	1273709	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctccgccccgctgtcctcGccctcccctgcccctggctg	8	24	0	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr11:1273709G>A	uc009ycr.1	+	53	16092	c.15966G>A	c.(15964-15966)TCG>TCA	p.S5322S	MUC5B_uc001ltb.2_Silent_p.S5003S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5000					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGCTGTCCTCGCCCTCCCCTG	0.682													A	1273709	A	A	1273709	2	1	273	1	0	0	0	0	0	0	0	1	9979	1074	38	1		1	MUC5B	11	1273709	Silent	SNP	G	TCGA-76-6286-01A-11D-1845-08		1273709	133732807	39	19597											
OR5P2	120065	broad.mit.edu	37	chr11	7818411	7818411	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gatcatgaagaggatgactcGaaggattggatcatctgtta	12	5	3	3			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr11:7818411G>A	uc001mfp.1	-	1	79	c.79C>T	c.(79-81)CGA>TGA	p.R27*		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	27	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGGATGACTCGAAGGATTGGA	0.428													A	7818411	A	A	7818411	4	1	273	1	0	0	0	0	0	1	0	0	11178	1066	37	2	893	2	OR5P2	11	7818411	Nonsense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	6544702	7818411	127188105	40	19598											
OR5W2	390148	broad.mit.edu	37	chr11	55681277	55681277	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagaataggaagaacttggcCggaaatacataaagagcaga	12	5	0	4			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr11:55681277C>T	uc010rir.1	-	1	782	c.782G>A	c.(781-783)CGG>CAG	p.R261Q		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R261W(1)		ovary(1)|skin(1)	2						AGAACTTGGCCGGAAATACAT	0.443													T	55681277	T	T	55681277	3	4	273	1	0	0	0	0	1	0	0	0	11185	652	23	2	152	2	OR5W2	11	55681277	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	47862866	55681277	79325239	41	19599											
MAP3K11	4296	broad.mit.edu	37	chr11	65375157	65375157	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagagaccctggatctcgcgCttccagccttcctgcatgga	10	14	1	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr11:65375157C>T	uc001oew.2	-	4	1693	c.1200G>A	c.(1198-1200)AAG>AAA	p.K400K	MAP3K11_uc001oev.2_5'Flank|MAP3K11_uc010rol.1_Silent_p.K143K|MAP3K11_uc001oex.1_5'UTR	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	400					activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						GGATCTCGCGCTTCCAGCCTT	0.617													T	65375157	T	T	65375157	2	4	273	1	0	0	0	0	0	0	0	1	9245	796	28	3		3	MAP3K11	11	65375157	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08	9693880	65375157	69631359	42	19600											
HEPHL1	341208	broad.mit.edu	37	chr11	93808410	93808410	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtggacagtgcctgagagCgtaagcccaactgctggtga	14	9	0	2	rs61746203		TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr11:93808410C>T	uc001pep.2	+	9	1732	c.1575C>T	c.(1573-1575)AGC>AGT	p.S525S	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	525	Plastocyanin-like 3.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TGCCTGAGAGCGTAAGCCCAA	0.468													T	93808410	T	T	93808410	2	4	273	1	0	0	0	0	0	0	0	1	7055	767	27	1		1	HEPHL1	11	93808410	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08	28433253	93808410	41198106	43	19601											
PDZD3	79849	broad.mit.edu	37	chr11	119059542	119059542	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctatggcttccgactcagttGtgtggccagtgggcctcgtc	13	12	1	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr11:119059542G>T	uc001pwb.2	+	7	1975	c.1451G>T	c.(1450-1452)TGT>TTT	p.C484F	PDZD3_uc001pvy.2_Missense_Mutation_p.C404F|PDZD3_uc001pvz.2_Missense_Mutation_p.C418F|PDZD3_uc010rzd.1_Missense_Mutation_p.C405F|PDZD3_uc001pwa.2_Missense_Mutation_p.C114F			Q86UT5	NHRF4_HUMAN	RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF4;          Short=NHERF-4; AltName: Full=PDZ domain-containing protein 3; AltName: Full=PDZ domain-containing protein 2; AltName: Full=Intestinal and kidney-enriched PDZ protein; AltName: Full=Sodium-hydrogen exchanger regulatory factor 4;	484	PDZ 4.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)	1	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		CGACTCAGTTGTGTGGCCAGT	0.572													T	119059542	T	T	119059542	3	4	273	1	0	0	0	0	1	0	0	0	11702	1377	48	5	1287	5	PDZD3	11	119059542	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	25251132	119059542	15946974	44	19602											
CSDA	8531	broad.mit.edu	37	chr12	10854621	10854621	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgccggtaattgtagggacGccggtatccacggcgaacag	14	11	0	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr12:10854621G>A	uc001qyt.2	-	8	1234	c.991C>T	c.(991-993)CGT>TGT	p.R331C	CSDA_uc001qyu.2_Missense_Mutation_p.R262C	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	331					negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)					TTGTAGGGACGCCGGTATCCA	0.567													A	10854621	A	A	10854621	3	1	273	1	0	0	0	0	1	0	0	0	3927	1087	38	1	135	1	CSDA	12	10854621	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08		10854621	122997274	45	19603											
KRT86	3892	broad.mit.edu	37	chr12	52699175	52699175	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgggctgaggccgagtcctGgtaccgcagcaaggtgagtg	17	11	0	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr12:52699175G>A	uc010snq.1	+	6	1020	c.887G>A	c.(886-888)TGG>TAG	p.W296*	KRT86_uc009zmg.2_Nonsense_Mutation_p.W296*|KRT81_uc001sac.2_Intron|KRT86_uc001sad.2_Nonsense_Mutation_p.W296*	NM_002284	NP_002275	O43790	KRT86_HUMAN	keratin 86	296	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCGAGTCCTGGTACCGCAGC	0.542													A	52699175	A	A	52699175	4	1	273	1	0	0	0	0	0	1	0	0	8500	1357	47	3	905	3	KRT86	12	52699175	Nonsense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	41844554	52699175	81152720	46	19604											
PTPRB	5787	broad.mit.edu	37	chr12	70990028	70990028	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tatgaggtgacttttccggaAgaaggagtccaccaaacatg	11	8	0	3			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr12:70990028A>G	uc001swb.3	-	3	435	c.405T>C	c.(403-405)TCT>TCC	p.S135S	PTPRB_uc010sto.1_Silent_p.S135S|PTPRB_uc010stp.1_Silent_p.S135S|PTPRB_uc001swc.3_Silent_p.S353S|PTPRB_uc001swa.3_Silent_p.S353S|PTPRB_uc001swd.3_Silent_p.S352S|PTPRB_uc009zrr.1_Silent_p.S232S|PTPRB_uc001swe.2_Silent_p.S353S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	135	Fibronectin type-III 2.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTTTTCCGGAAGAAGGAGTCC	0.408													G	70990028	G	G	70990028	2	3	273	1	0	0	0	0	0	0	0	1	12796	59	3	4		4	PTPRB	12	70990028	Silent	SNP	A	TCGA-76-6286-01A-11D-1845-08	18290853	70990028	62861867	47	19605											
RIMBP2	23504	broad.mit.edu	37	chr12	130907060	130907060	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgctgccacggggaaacctcCggcccatgtgatccacccgt	11	17	0	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr12:130907060C>T	uc001uil.2	-	13	2572	c.2408G>A	c.(2407-2409)CGG>CAG	p.R803Q		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	803						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGGAAACCTCCGGCCCATGTG	0.567													T	130907060	T	T	130907060	3	4	273	1	0	0	0	0	1	0	0	0	13363	652	23	2	778	2	RIMBP2	12	130907060	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	59917032	130907060	2944835	48	19606											
SACS	26278	broad.mit.edu	37	chr13	23913301	23913301	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	catgaattcccgactcataaTgatgggaatgtcagtgatat	9	7	2	3			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr13:23913301T>C	uc001uon.2	-	10	5303	c.4714A>G	c.(4714-4716)ATT>GTT	p.I1572V	SACS_uc001uoo.2_Missense_Mutation_p.I1425V|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1572					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CGACTCATAATGATGGGAATG	0.338													C	23913301	C	C	23913301	3	2	273	1	0	0	0	0	1	0	0	0	13804	1464	51	4	9029	4	SACS	13	23913301	Missense_Mutation	SNP	T	TCGA-76-6286-01A-11D-1845-08		23913301	91256577	49	19607											
RB1	5925	broad.mit.edu	37	chr13	48941694	48941694	+	Nonsense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taaagatctagatgcaagatTatttttggatcatgataaaa	7	3	2	4			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr13:48941694T>G	uc001vcb.2	+	10	1170	c.1004T>G	c.(1003-1005)TTA>TGA	p.L335*	RB1_uc010act.1_Nonsense_Mutation_p.L36*	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	335					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATGCAAGATTATTTTTGGAT	0.284		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			G	48941694	G	G	48941694	4	3	273	1	0	0	0	0	0	1	0	0	13098	1764	61	5	1042	5	RB1	13	48941694	Nonsense_Mutation	SNP	T	TCGA-76-6286-01A-11D-1845-08	25028393	48941694	66228184	50	19608											
FARP1	10160	broad.mit.edu	37	chr13	98865588	98865588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttggaacgtggacagaagcCgcccccaacaccttcaggaa	10	14	1	1	rs113972742		TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr13:98865588C>T	uc001vnj.2	+	2	428	c.92C>T	c.(91-93)CCG>CTG	p.P31L	FARP1_uc001vnh.2_Missense_Mutation_p.P31L|FARP1_uc001vni.2_Missense_Mutation_p.P31L	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	31					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GGACAGAAGCCGCCCCCAACA	0.537													T	98865588	T	T	98865588	3	4	273	1	0	0	0	0	1	0	0	0	5676	652	23	2	94	2	FARP1	13	98865588	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	49923894	98865588	16304290	51	19609											
OR11H12	440153	broad.mit.edu	37	chr14	19378054	19378054	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctaatatcatgactgggcAtctctgtgccaaactggtca	8	11	3	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr14:19378054A>C	uc010tkp.1	+	1	461	c.461A>C	c.(460-462)CAT>CCT	p.H154P		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	154	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATGACTGGGCATCTCTGTGCC	0.478													C	19378054	C	C	19378054	3	2	273	1	0	0	0	0	1	0	0	0	10927	217	8	5	463	5	OR11H12	14	19378054	Missense_Mutation	SNP	A	TCGA-76-6286-01A-11D-1845-08		19378054	87971486	52	19610											
DYNC1H1	1778	broad.mit.edu	37	chr14	102467294	102467294	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tatgtttctctcgacagcttCgacaaaatttggatgccctc	7	11	1	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr14:102467294C>T	uc001yks.2	+	19	4242	c.4078C>T	c.(4078-4080)CGA>TGA	p.R1360*		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	1360	Stem (By similarity).|Potential.				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TCGACAGCTTCGACAAAATTT	0.373													T	102467294	T	T	102467294	4	4	273	1	0	0	0	0	0	1	0	0	4841	876	31	2	4152	2	DYNC1H1	14	102467294	Nonsense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	83089240	102467294	4882246	53	19611											
EHD4	30844	broad.mit.edu	37	chr15	42193062	42193062	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcaccatctccttcttggcGttgacacctgatatcttgcc	7	14	4	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr15:42193062G>A	uc001zot.2	-	6	1470	c.1407C>T	c.(1405-1407)AAC>AAT	p.N469N		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	469	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		CCTTCTTGGCGTTGACACCTG	0.592													A	42193062	A	A	42193062	2	1	273	1	0	0	0	0	0	0	0	1	4980	1136	40	1		1	EHD4	15	42193062	Silent	SNP	G	TCGA-76-6286-01A-11D-1845-08		42193062	60338330	54	19612											
KIF7	374654	broad.mit.edu	37	chr15	90188330	90188330	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgctgggcctgggccagcCgccactctgaggctgtggca	15	14	2	1	rs149078926	byFrequency	TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr15:90188330C>T	uc002bof.2	-	10	2182	c.2105G>A	c.(2104-2106)CGG>CAG	p.R702Q	KIF7_uc010upw.1_Missense_Mutation_p.R188Q	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	702	Potential.				microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CTGGGCCAGCCGCCACTCTGA	0.652													T	90188330	T	T	90188330	3	4	273	1	0	0	0	0	1	0	0	0	8309	652	23	2	1966	2	KIF7	15	90188330	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	47995268	90188330	12343062	55	19613											
NXN	64359	broad.mit.edu	37	chr17	708351	708351	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccctcgttaagctgcgcggcGttggagtcggagagctccag	15	12	0	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr17:708351G>A	uc002fsa.2	-	6	1049	c.957C>T	c.(955-957)AAC>AAT	p.N319N	NXN_uc010vqd.1_Intron|NXN_uc002frz.2_Silent_p.N70N|NXN_uc010vqe.1_Silent_p.N211N	NM_022463	NP_071908	Q6DKJ4	NXN_HUMAN	nucleoredoxin	319	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			ovary(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		GCTGCGCGGCGTTGGAGTCGG	0.692													A	708351	A	A	708351	2	1	273	1	0	0	0	0	0	0	0	1	10787	1136	40	1		1	NXN	17	708351	Silent	SNP	G	TCGA-76-6286-01A-11D-1845-08		708351	80486859	56	19614											
TP53	7157	broad.mit.edu	37	chr17	7572986	7572986	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tttatggcgggaggtagactGaccctttttggacttcaggt	13	7	1	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr17:7572986G>T	uc002gim.2	-	11	1317	c.1123C>A	c.(1123-1125)CAG>AAG	p.Q375K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Missense_Mutation_p.Q243K|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Missense_Mutation_p.Q375K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	375	Basic (repression of DNA-binding).|Interaction with CARM1.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGTAGACTGACCCTTTTTG	0.527		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7572986	T	T	7572986	3	4	273	1	0	0	0	0	1	0	0	0	16378	1299	45	5	62	5	TP53	17	7572986	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	6864635	7572986	73622224	57	19615											
TP53	7157	broad.mit.edu	37	chr17	7577580	7577580	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aactgttacacatgtagttgTagtggatggtggtacagtca	12	5	1	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr17:7577580T>C	uc002gim.2	-	7	895	c.701A>G	c.(700-702)TAC>TGC	p.Y234C	TP53_uc002gig.1_Missense_Mutation_p.Y234C|TP53_uc002gih.2_Missense_Mutation_p.Y234C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y102C|TP53_uc010cng.1_Missense_Mutation_p.Y102C|TP53_uc002gii.1_Missense_Mutation_p.Y102C|TP53_uc010cnh.1_Missense_Mutation_p.Y234C|TP53_uc010cni.1_Missense_Mutation_p.Y234C|TP53_uc002gij.2_Missense_Mutation_p.Y234C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y141C|TP53_uc002gio.2_Missense_Mutation_p.Y102C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	234	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> F (in a sporadic cancer; somatic mutation).|Y -> K (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|Y -> N (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> Q (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y234C(70)|p.Y234H(13)|p.Y234N(11)|p.0?(7)|p.Y234S(6)|p.Y234*(4)|p.Y234D(3)|p.Y234del(3)|p.Y234fs*2(1)|p.V225fs*23(1)|p.Y234fs*6(1)|p.Y234fs*5(1)|p.Y234fs*4(1)|p.Y234R(1)|p.Y234Y(1)|p.H233_C242del10(1)|p.D228fs*12(1)|p.Y234F(1)|p.I232_Y236delIHYNY(1)|p.Y141S(1)|p.T230_Y234delTTIHY(1)|p.H233fs*6(1)|p.Y234_N235insX(1)|p.I232fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGTAGTTGTAGTGGATGGT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			C	7577580	C	C	7577580	3	2	273	1	0	0	0	0	1	0	0	0	16378	1638	57	4	589	4	TP53	17	7577580	Missense_Mutation	SNP	T	TCGA-76-6286-01A-11D-1845-08	4594	7577580	73617630	58	19616											
GRB7	2886	broad.mit.edu	37	chr17	37901165	37901165	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aagcttcgaaatggccacaaGgggcttcggatcttctgcag	12	10	2	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr17:37901165G>C	uc002hsr.2	+	9	1189	c.939G>C	c.(937-939)AAG>AAC	p.K313N	GRB7_uc002hss.2_Missense_Mutation_p.K313N|GRB7_uc010cwc.2_Missense_Mutation_p.K313N|GRB7_uc002hst.2_Missense_Mutation_p.K313N	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	313	PH.				blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			ATGGCCACAAGGGGCTTCGGA	0.582													C	37901165	C	C	37901165	3	2	273	1	0	0	0	0	1	0	0	0	6759	991	35	5	969	5	GRB7	17	37901165	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	30323585	37901165	43294045	59	19617											
KRT25	147183	broad.mit.edu	37	chr17	38910206	38910206	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acagggttatttcatccaaaActcttcgtaacccattgaca	5	11	2	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr17:38910206A>G	uc002hve.2	-	3	636	c.575T>C	c.(574-576)GTT>GCT	p.V192A		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	192	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				TTCATCCAAAACTCTTCGTAA	0.403													G	38910206	G	G	38910206	3	3	273	1	0	0	0	0	1	0	0	0	8462	43	2	4	801	4	KRT25	17	38910206	Missense_Mutation	SNP	A	TCGA-76-6286-01A-11D-1845-08	1009041	38910206	42285004	60	19618											
INTS2	57508	broad.mit.edu	37	chr17	59946709	59946709	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgcatagatggaatacctgcGaccgtcagaggcaaaagttc	11	9	1	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr17:59946709G>A	uc002izn.2	-	22	3163	c.3087C>T	c.(3085-3087)GTC>GTT	p.V1029V	INTS2_uc002izm.2_Silent_p.V1021V	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	1029					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						GAATACCTGCGACCGTCAGAG	0.333													A	59946709	A	A	59946709	2	1	273	1	0	0	0	0	0	0	0	1	7778	1045	37	2		2	INTS2	17	59946709	Silent	SNP	G	TCGA-76-6286-01A-11D-1845-08	21036503	59946709	21248501	61	19619											
MRPS7	51081	broad.mit.edu	37	chr17	73258939	73258939	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaagtactggccagatccctCatgattcaggtaaacagcac	8	11	2	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr17:73258939C>T	uc002jnm.3	+	3	563	c.330C>T	c.(328-330)CTC>CTT	p.L110L	GGA3_uc002jni.1_5'Flank|GGA3_uc002jnj.1_5'Flank|GGA3_uc010wrw.1_5'Flank|GGA3_uc002jnk.1_5'Flank|GGA3_uc010wrx.1_5'Flank|GGA3_uc010wry.1_5'Flank|GGA3_uc010wrz.1_5'Flank|MRPS7_uc002jnl.2_Silent_p.L110L|MRPS7_uc002jnn.3_Silent_p.L139L	NM_015971	NP_057055	Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7 precursor	110					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			central_nervous_system(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CCAGATCCCTCATGATTCAGG	0.448													T	73258939	T	T	73258939	2	4	273	1	0	0	0	0	0	0	0	1	9848	813	29	3		3	MRPS7	17	73258939	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08	13312230	73258939	7936271	62	19620											
GAMT	2593	broad.mit.edu	37	chr19	1397419	1397419	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtagtagcggcagtcggccGgtgggaccagcgccatcacc	15	14	1	0	rs139890971		TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr19:1397419G>A	uc002lsj.2	-	6	727	c.650C>T	c.(649-651)CCG>CTG	p.P217L	uc002lsi.1_5'Flank	NM_000156	NP_000147	Q14353	GAMT_HUMAN	guanidinoacetate N-methyltransferase isoform a	217					creatine biosynthetic process|muscle contraction	cytosol	guanidinoacetate N-methyltransferase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Lung NSC(49;0.000195)|Breast(49;0.000231)|all_lung(49;0.000247)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Creatine(DB00148)	GCAGTCGGCCGGTGGGACCAG	0.701													A	1397419	A	A	1397419	3	1	273	1	0	0	0	0	1	0	0	0	6231	1116	39	2	64	2	GAMT	19	1397419	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08		1397419	57731564	63	19621											
TJP3	27134	broad.mit.edu	37	chr19	3738562	3738562	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctttctggcaggtgaatgacGtgccattccagaacctgaca	10	11	1	4			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr19:3738562G>A	uc010xhv.1	+	11	1393	c.1393G>A	c.(1393-1395)GTG>ATG	p.V465M	TJP3_uc010xhs.1_Missense_Mutation_p.V432M|TJP3_uc010xht.1_Missense_Mutation_p.V396M|TJP3_uc010xhu.1_Missense_Mutation_p.V441M|TJP3_uc010xhw.1_Missense_Mutation_p.V451M	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	446	PDZ 3.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGAATGACGTGCCATTCCA	0.577													A	3738562	A	A	3738562	3	1	273	1	0	0	0	0	1	0	0	0	15928	1145	40	1	1435	1	TJP3	19	3738562	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	2341143	3738562	55390421	64	19622											
PNPLA6	10908	broad.mit.edu	37	chr19	7607932	7607932	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcagagtcttgctgcaccacGccaaagctggcaccatcatt	9	14	2	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr19:7607932G>A	uc010xjq.1	+	15	1792	c.1597G>A	c.(1597-1599)GCC>ACC	p.A533T	PNPLA6_uc002mgq.1_Missense_Mutation_p.A485T|PNPLA6_uc010xjp.1_Intron|PNPLA6_uc002mgr.1_Missense_Mutation_p.A485T|PNPLA6_uc002mgs.2_Missense_Mutation_p.A524T	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	524	cNMP 2.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						GCTGCACCACGCCAAAGCTGG	0.627													A	7607932	A	A	7607932	3	1	273	1	0	0	0	0	1	0	0	0	12169	1087	38	1	1651	1	PNPLA6	19	7607932	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	3869370	7607932	51521051	65	19623											
SLC1A6	6511	broad.mit.edu	37	chr19	15067342	15067342	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	gtagcatgcccccaatgaagGggaaggggttccggtgagtg	17	8	0	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr19:15067342G>C	uc002naa.1	-	6	1123	c.1115C>G	c.(1114-1116)CCC>CGC	p.P372R	SLC1A6_uc010dzu.1_Intron|SLC1A6_uc010xod.1_Missense_Mutation_p.P308R	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	372	Helical; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	CCCAATGAAGGGGAAGGGGTT	0.592													C	15067342	C	C	15067342	3	2	273	1	0	0	0	0	1	0	0	0	14436	1232	43	5	595	5	SLC1A6	19	15067342	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	7459410	15067342	44061641	66	19624											
RASAL3	64926	broad.mit.edu	37	chr19	15574925	15574925	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggccttggagagtcgaaggCgactggtccgtgactccttg	16	10	0	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr19:15574925C>T	uc002nbe.2	-	2	331	c.245G>A	c.(244-246)CGC>CAC	p.R82H		NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	82					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						GAGTCGAAGGCGACTGGTCCG	0.672													T	15574925	T	T	15574925	3	4	273	1	0	0	0	0	1	0	0	0	13065	768	27	1	2858	1	RASAL3	19	15574925	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	507583	15574925	43554058	67	19625											
F2RL3	9002	broad.mit.edu	37	chr19	17000842	17000842	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcccgcgccctgcgtggcCggcgcctggcccttggactc	16	18	0	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr19:17000842C>T	uc002nfa.2	+	2	743	c.568C>T	c.(568-570)CGG>TGG	p.R190W		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	190	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						CCTGCGTGGCCGGCGCCTGGC	0.711													T	17000842	T	T	17000842	3	4	273	1	0	0	0	0	1	0	0	0	5346	643	23	2	574	2	F2RL3	19	17000842	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	1425917	17000842	42128141	68	19626											
RASGRP4	115727	broad.mit.edu	37	chr19	38909096	38909096	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggcccgggacggctcagcaCcatcacctgcacccagcggg	14	17	2	0			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr19:38909096C>G	uc002oir.2	-	7	986	c.772G>C	c.(772-774)GTG>CTG	p.V258L	RASGRP4_uc010efz.1_RNA|RASGRP4_uc010ega.1_RNA|RASGRP4_uc010xua.1_Missense_Mutation_p.V258L|RASGRP4_uc010xub.1_Missense_Mutation_p.V224L|RASGRP4_uc010xuc.1_Missense_Mutation_p.V258L|RASGRP4_uc010xud.1_Intron|RASGRP4_uc010xue.1_Intron|RASGRP4_uc010egb.2_Missense_Mutation_p.V244L	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	258	Ras-GEF.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CGGCTCAGCACCATCACCTGC	0.662													G	38909096	G	G	38909096	3	3	273	1	0	0	0	0	1	0	0	0	13077	507	18	5	1293	5	RASGRP4	19	38909096	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	21908254	38909096	20219887	69	19627											
SIGLEC10	89790	broad.mit.edu	37	chr19	51919569	51919569	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacggccctcagtacctggcGtgttgtcacgtgaaatgctg	13	11	2	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr19:51919569G>A	uc002pwo.2	-	4	1365	c.749C>T	c.(748-750)ACG>ATG	p.T250M	SIGLEC10_uc002pwp.2_Missense_Mutation_p.T192M|SIGLEC10_uc002pwq.2_Missense_Mutation_p.T192M|SIGLEC10_uc002pwr.2_Missense_Mutation_p.T250M|SIGLEC10_uc010ycy.1_Missense_Mutation_p.T250M|SIGLEC10_uc010ycz.1_Missense_Mutation_p.T202M|SIGLEC10_uc010eow.2_Missense_Mutation_p.R15C|SIGLEC10_uc002pws.1_Missense_Mutation_p.T176M	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	250	Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AGTACCTGGCGTGTTGTCACG	0.483													A	51919569	A	A	51919569	3	1	273	1	0	0	0	0	1	0	0	0	14306	1145	40	1	1376	1	SIGLEC10	19	51919569	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	13010473	51919569	7209414	70	19628											
ZSCAN1	284312	broad.mit.edu	37	chr19	58564824	58564824	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccgcttgcctctgaagcCgagtatctgggacgagcctg	14	13	2	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr19:58564824C>T	uc002qrc.1	+	6	879	c.632C>T	c.(631-633)CCG>CTG	p.P211L		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	211					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCTCTGAAGCCGAGTATCTGG	0.652													T	58564824	T	T	58564824	3	4	273	1	0	0	0	0	1	0	0	0	18223	652	23	2	646	2	ZSCAN1	19	58564824	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	6645255	58564824	564159	71	19629											
ZNF831	128611	broad.mit.edu	37	chr20	57768855	57768855	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accccacctcaggctcctagAgtgctctctgccctggcaga	9	17	2	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr20:57768855A>C	uc002yan.2	+	1	2781	c.2781A>C	c.(2779-2781)AGA>AGC	p.R927S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	927						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGGCTCCTAGAGTGCTCTCTG	0.632													C	57768855	C	C	57768855	3	2	273	1	0	0	0	0	1	0	0	0	18182	301	11	5	2783	5	ZNF831	20	57768855	Missense_Mutation	SNP	A	TCGA-76-6286-01A-11D-1845-08		57768855	5256665	72	19630											
CDH4	1002	broad.mit.edu	37	chr20	60503346	60503346	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccaaggaggcgcagatctgcGagaagcccaacctgaacgcc	12	14	1	3			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr20:60503346G>A	uc002ybn.1	+	12	1884	c.1870G>A	c.(1870-1872)GAG>AAG	p.E624K	CDH4_uc002ybp.1_Missense_Mutation_p.E550K	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	624	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GCAGATCTGCGAGAAGCCCAA	0.642													A	60503346	A	A	60503346	3	1	273	1	0	0	0	0	1	0	0	0	3112	1059	37	2	1916	2	CDH4	20	60503346	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	2734491	60503346	2522174	73	19631											
HRH3	11255	broad.mit.edu	37	chr20	60793588	60793588	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcggtcgtagctgatgagcaCgatgttgaaggcagaggagg	18	6	0	4	rs142903103		TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr20:60793588C>T	uc002ycf.2	-	2	673	c.376G>A	c.(376-378)GTG>ATG	p.V126M	HRH3_uc002ycg.2_Missense_Mutation_p.V126M|HRH3_uc002ych.2_Missense_Mutation_p.V126M|HRH3_uc002yci.2_Missense_Mutation_p.V126M	NM_007232	NP_009163	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	126	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	CTGATGAGCACGATGTTGAAG	0.647													T	60793588	T	T	60793588	3	4	273	1	0	0	0	0	1	0	0	0	7357	536	19	1	969	1	HRH3	20	60793588	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	290242	60793588	2231932	74	19632											
KRTAP13-1	140258	broad.mit.edu	37	chr21	31768677	31768677	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctccttgctctgcagtccCtgccagacaacttactctgg	7	16	2	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr21:31768677C>T	uc002yoa.2	+	1	286	c.273C>T	c.(271-273)CCC>CCT	p.P91P		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	91	5 X 10 AA approximate repeats.					intermediate filament				ovary(1)	1						TCTGCAGTCCCTGCCAGACAA	0.612													T	31768677	T	T	31768677	2	4	273	1	0	0	0	0	0	0	0	1	8522	668	24	3		3	KRTAP13-1	21	31768677	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08		31768677	16361218	75	19633											
FAM3B	54097	broad.mit.edu	37	chr21	42720528	42720528	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgtcctgcagactgaataaCgatgccaagaatgccataga	9	9	0	4			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chr21:42720528C>T	uc002yzb.1	+	7	641	c.495C>T	c.(493-495)AAC>AAT	p.N165N	FAM3B_uc002yza.2_RNA|FAM3B_uc002yzc.1_Silent_p.N117N|FAM3B_uc002yzd.1_Silent_p.N188N	NM_058186	NP_478066	P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	165					apoptosis|insulin secretion	extracellular space	cytokine activity				0		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				GACTGAATAACGATGCCAAGA	0.463													T	42720528	T	T	42720528	2	4	273	1	0	0	0	0	0	0	0	1	5557	535	19	1		1	FAM3B	21	42720528	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08	10951851	42720528	5409367	76	19634											
MSL3	10943	broad.mit.edu	37	chrX	11790368	11790371	+	Frame_Shift_Del	DEL	TTGT	-	-													gggcacaacatttgctgcgaTtgtttggtaagaatcctggt							TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chrX:11790368_11790371delTTGT	uc004cuw.2	+	11	1480_1483	c.1375_1378delTTGT	c.(1375-1380)TTGTTTfs	p.L459fs	MSL3_uc004cux.2_Frame_Shift_Del_p.L400fs|MSL3_uc011mig.1_Frame_Shift_Del_p.L310fs|MSL3_uc011mih.1_Frame_Shift_Del_p.L447fs|MSL3_uc004cuy.2_Frame_Shift_Del_p.L293fs	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	459_460					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTTGCTGCGATTGTTTGGTAAGAA	0.451													-	11790371	-	-	11790368	7	5	273	1	0	1	0	1	0	0	0	0	9879	1490	52	0	1497	0	MSL3	23	11790368	Frame_Shift_Del	DEL	TTGT	TCGA-76-6286-01A-11D-1845-08		11790368	143480192	77	19635											
KCND1	3750	broad.mit.edu	37	chrX	48819889	48819889	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggggaagaggcaaggggtacCcaggctggagttcctgaggg	20	7	0	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chrX:48819889C>T	uc004dlx.1	-	6	3470	c.1897G>A	c.(1897-1899)GGT>AGT	p.G633S	KCND1_uc004dlw.1_Missense_Mutation_p.G256S	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	633	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						CAAGGGGTACCCAGGCTGGAG	0.612													T	48819889	T	T	48819889	3	4	273	1	0	0	0	0	1	0	0	0	8018	623	22	3	50	3	KCND1	23	48819889	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	37029521	48819889	106450671	78	19636											
VSIG4	11326	broad.mit.edu	37	chrX	65242302	65242302	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	acttgcgaagatggccacccTcatggtttctccagagtcgt	10	12	2	2			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chrX:65242302T>C	uc004dwh.2	-	8	1130	c.1003A>G	c.(1003-1005)AGG>GGG	p.R335G	VSIG4_uc004dwi.2_Missense_Mutation_p.R241G|VSIG4_uc010nkq.1_3'UTR|VSIG4_uc004dwj.2_3'UTR|VSIG4_uc011moy.1_3'UTR|VSIG4_uc004dwk.2_Intron|VSIG4_uc004dwl.2_Intron	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	335	Cytoplasmic (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						ATGGCCACCCTCATGGTTTCT	0.567													C	65242302	C	C	65242302	3	2	273	1	0	0	0	0	1	0	0	0	17222	1550	54	4	200	4	VSIG4	23	65242302	Missense_Mutation	SNP	T	TCGA-76-6286-01A-11D-1845-08	16422413	65242302	90028258	79	19637											
USP26	83844	broad.mit.edu	37	chrX	132161219	132161219	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctttaaaaaaaagtagccGtgccaagcacatggtaagag	9	7	1	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chrX:132161219G>A	uc010nrm.1	-	6	1500	c.1030C>T	c.(1030-1032)CGG>TGG	p.R344W	USP26_uc011mvf.1_Missense_Mutation_p.R344W	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	344					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					AAAAGTAGCCGTGCCAAGCAC	0.378													A	132161219	A	A	132161219	3	1	273	1	0	0	0	0	1	0	0	0	17054	1144	40	1	1714	1	USP26	23	132161219	Missense_Mutation	SNP	G	TCGA-76-6286-01A-11D-1845-08	66918917	132161219	23109341	80	19638											
AFF2	2334	broad.mit.edu	37	chrX	147924922	147924922	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcagagtggaatgacccaacCaccagagcttctacaaagtc	8	12	2	3			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chrX:147924922C>A	uc004fcp.2	+	7	1706	c.1227C>A	c.(1225-1227)ACC>ACA	p.T409T	AFF2_uc004fco.2_Silent_p.T376T|AFF2_uc004fcq.2_Silent_p.T405T|AFF2_uc004fcr.2_Silent_p.T376T|AFF2_uc011mxb.1_Silent_p.T380T|AFF2_uc004fcs.2_Silent_p.T376T|AFF2_uc011mxc.1_Silent_p.T50T	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	409					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					ATGACCCAACCACCAGAGCTT	0.378													A	147924922	A	A	147924922	2	1	273	1	0	0	0	0	0	0	0	1	357	581	21	5		5	AFF2	23	147924922	Silent	SNP	C	TCGA-76-6286-01A-11D-1845-08	15763703	147924922	7345638	81	19639											
FLNA	2316	broad.mit.edu	37	chrX	153588445	153588445	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttgctggggaagttgggcaCgggctggccgccgtacttga	17	10	0	1			TCGA-76-6286-01A-11D-1845-08	TCGA-76-6286-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	45d03116-6cff-4074-9c26-2e5f1a8854d3	2159e2bc-ad84-4c6f-a4b9-d8f27800b900	g.chrX:153588445C>T	uc004fkk.2	-	22	3967	c.3718G>A	c.(3718-3720)GTG>ATG	p.V1240M	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Missense_Mutation_p.V1240M	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1240	Filamin 10.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AAGTTGGGCACGGGCTGGCCG	0.627													T	153588445	T	T	153588445	3	4	273	1	0	0	0	0	1	0	0	0	5933	536	19	1	4333	1	FLNA	23	153588445	Missense_Mutation	SNP	C	TCGA-76-6286-01A-11D-1845-08	5663523	153588445	1682115	82	19640											
CDA	978	broad.mit.edu	37	chr1	20944980	20944980	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cccgtgtacatgaccaagccGgatggtacgtatattgtcat	10	10	1	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:20944980G>A	uc001bdk.2	+	4	539	c.360G>A	c.(358-360)CCG>CCA	p.P120P	CDA_uc001bdl.2_RNA|CDA_uc009vpv.2_RNA	NM_001785	NP_001776	P32320	CDD_HUMAN	cytidine deaminase	120					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	TGACCAAGCCGGATGGTACGT	0.403													A	20944980	A	A	20944980	2	1	274	1	0	0	0	0	0	0	0	1	3052	1103	39	2		2	CDA	1	20944980	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08		20944980	228305641	1	19641											
GRIK3	2899	broad.mit.edu	37	chr1	37356675	37356675	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgacctgggcgttggggccGtccgcatactcgaagattcc	13	12	0	2	rs150456185		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:37356675G>A	uc001caz.2	-	2	273	c.138C>T	c.(136-138)GAC>GAT	p.D46D	GRIK3_uc001cba.1_Silent_p.D46D	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	46	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CGTTGGGGCCGTCCGCATACT	0.507													A	37356675	A	A	37356675	2	1	274	1	0	0	0	0	0	0	0	1	6775	1136	40	1		1	GRIK3	1	37356675	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08	16411695	37356675	211893946	2	19642											
PTPRF	5792	broad.mit.edu	37	chr1	44086251	44086251	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaaggtcacggatgcccggGtgagtgagtgcattgagtgt	16	7	2	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:44086251G>A	uc001cjr.2	+	31	5704	c.5364_splice	c.e31+1	p.R1788_splice	PTPRF_uc001cjs.2_Splice_Site_p.R1779_splice|PTPRF_uc001cju.2_Splice_Site_p.R1177_splice|PTPRF_uc009vwt.2_Splice_Site_p.R1348_splice|PTPRF_uc001cjv.2_Splice_Site_p.R1259_splice|PTPRF_uc001cjw.2_Splice_Site_p.R1014_splice	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F						transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGATGCCCGGGTGAGTGAGTG	0.547													A	44086251	A	A	44086251	5	1	274	1	0	0	0	0	0	0	1	0	12801	1275	44	3	5479	3	PTPRF	1	44086251	Splice_Site	SNP	G	TCGA-76-6656-01A-11D-1845-08	6729576	44086251	205164370	3	19643											
NEGR1	257194	broad.mit.edu	37	chr1	72058647	72058647	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aattccttgttggccattgaAgagcctagaagacaaaataa	8	7	0	4			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:72058647A>G	uc001dfw.2	-	6	893	c.793T>C	c.(793-795)TTC>CTC	p.F265L	NEGR1_uc001dfv.2_Missense_Mutation_p.F137L|NEGR1_uc010oqs.1_Missense_Mutation_p.F221L	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	265	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		TGGCCATTGAAGAGCCTAGAA	0.373													G	72058647	G	G	72058647	3	3	274	1	0	0	0	0	1	0	0	0	10317	72	3	4	279	4	NEGR1	1	72058647	Missense_Mutation	SNP	A	TCGA-76-6656-01A-11D-1845-08	27972396	72058647	177191974	4	19644											
COL24A1	255631	broad.mit.edu	37	chr1	86282552	86282552	+	Frame_Shift_Del	DEL	T	-	-													ccatggtatccttgtatgccTtttggcccaagtaggccttg							TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:86282552delT	uc001dlj.2	-	47	3912	c.3870delA	c.(3868-3870)AAAfs	p.K1290fs	COL24A1_uc001dli.2_Frame_Shift_Del_p.K426fs|COL24A1_uc010osd.1_Frame_Shift_Del_p.K590fs|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1290	Collagen-like 14.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTTGTATGCCTTTTGGCCCAA	0.388													-	86282552	-	-	86282552	7	5	274	1	0	1	0	1	0	0	0	0	3683	1606	56	0	1330	0	COL24A1	1	86282552	Frame_Shift_Del	DEL	T	TCGA-76-6656-01A-11D-1845-08	14223905	86282552	162968069	5	19645											
HFM1	164045	broad.mit.edu	37	chr1	91740328	91740328	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttttggagtaaaaccaaaCtctttaaggtccacactttg	8	8	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:91740328C>T	uc001doa.3	-	33	3727	c.3627G>A	c.(3625-3627)GAG>GAA	p.E1209E	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Silent_p.E888E|HFM1_uc001dob.3_Silent_p.E397E|HFM1_uc010osv.1_Silent_p.E893E	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1209							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TAAAACCAAACTCTTTAAGGT	0.299													T	91740328	T	T	91740328	2	4	274	1	0	0	0	0	0	0	0	1	7083	564	20	3		3	HFM1	1	91740328	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	5457776	91740328	157510293	6	19646											
FAM102B	284611	broad.mit.edu	37	chr1	109167309	109167309	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ataccaattgctggtgaatcTgaatctttgcaagaagatag	9	6	2	4			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:109167309T>C	uc010ouy.1	+	6	575	c.495T>C	c.(493-495)TCT>TCC	p.S165S		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611	165										large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		CTGGTGAATCTGAATCTTTGC	0.403													C	109167309	C	C	109167309	2	2	274	1	0	0	0	0	0	0	0	1	5383	1567	55	4		4	FAM102B	1	109167309	Silent	SNP	T	TCGA-76-6656-01A-11D-1845-08	17426981	109167309	140083312	7	19647											
RPTN	126638	broad.mit.edu	37	chr1	152128277	152128280	+	Frame_Shift_Del	DEL	TGTC	-	-													catagtgggaactctggcctTgtctgtctgtctgaccgtag							TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:152128277_152128280delTGTC	uc001ezs.1	-	3	1360_1363	c.1295_1298delGACA	c.(1294-1299)AGACAAfs	p.R432fs		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	432_433	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						ACTCTGGCCTTGTCTGTCTGTCTG	0.525													-	152128280	-	-	152128277	7	5	274	1	0	1	0	1	0	0	0	0	13664	1812	63	0	1060	0	RPTN	1	152128277	Frame_Shift_Del	DEL	TGTC	TCGA-76-6656-01A-11D-1845-08	42960968	152128277	97122344	8	19648											
FLG	2312	broad.mit.edu	37	chr1	152282565	152282565	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tcttctgagtgtccctcactGtccctgtcctgactaacact	6	15	3	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:152282565G>C	uc001ezu.1	-	3	4833	c.4797C>G	c.(4795-4797)GAC>GAG	p.D1599E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1599	Ser-rich.|Filaggrin 9.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCCTCACTGTCCCTGTCCT	0.592									Ichthyosis				C	152282565	C	C	152282565	3	2	274	1	0	0	0	0	1	0	0	0	5922	1368	48	5	7392	5	FLG	1	152282565	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	154288	152282565	96968056	9	19649											
HDGF	3068	broad.mit.edu	37	chr1	156713958	156713958	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaggcagcagttacctcCagcaagtcccctgctctcct	10	16	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:156713958C>T	uc001fpy.3	-	4	808	c.486G>A	c.(484-486)CTG>CTA	p.L162L	HDGF_uc009wsd.2_Silent_p.L130L|HDGF_uc001fpz.3_Silent_p.L155L|HDGF_uc009wse.2_Silent_p.L178L|HDGF_uc010phr.1_Silent_p.L185L|HDGF_uc009wsf.2_Silent_p.L130L|HDGF_uc009wsg.2_Silent_p.L162L	NM_004494	NP_004485	P51858	HDGF_HUMAN	hepatoma-derived growth factor isoform a	162	Bipartite nuclear localization signal.|Glu-rich.				cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			lung(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		CAGTTACCTCCAGCAAGTCCC	0.612													T	156713958	T	T	156713958	2	4	274	1	0	0	0	0	0	0	0	1	7018	581	21	3		3	HDGF	1	156713958	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	4431393	156713958	92536663	10	19650											
PTGS2	5743	broad.mit.edu	37	chr1	186645642	186645642	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggaacaactgctcatcaccCcattcaggatgctcctgttt	7	13	3	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:186645642C>T	uc001gsb.2	-	7	1064	c.927G>A	c.(925-927)TGG>TGA	p.W309*	PTGS2_uc009wyo.2_Nonsense_Mutation_p.W156*	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	309					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GCTCATCACCCCATTCAGGAT	0.448													T	186645642	T	T	186645642	4	4	274	1	0	0	0	0	0	1	0	0	12756	624	22	3	903	3	PTGS2	1	186645642	Nonsense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	29931684	186645642	62604979	11	19651											
OR6F1	343169	broad.mit.edu	37	chr1	247875393	247875393	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggatcctgaggatggtgctgAtgatgtacacataggagaca	14	6	0	4			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr1:247875393A>C	uc001idj.1	-	1	665	c.665T>G	c.(664-666)ATC>AGC	p.I222S		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GATGGTGCTGATGATGTACAC	0.532													C	247875393	C	C	247875393	3	2	274	1	0	0	0	0	1	0	0	0	11201	333	12	5	265	5	OR6F1	1	247875393	Missense_Mutation	SNP	A	TCGA-76-6656-01A-11D-1845-08	61229751	247875393	1375228	12	19652											
C2orf89	129293	broad.mit.edu	37	chr2	85051303	85051303	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatggtggacagagtgggccGtgtggaggtctttttactct	16	6	2	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr2:85051303G>A	uc010ysl.1	-	6	1197	c.1108C>T	c.(1108-1110)CGG>TGG	p.R370W	C2orf89_uc002sou.3_Missense_Mutation_p.R321W	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	370	Extracellular (Potential).					integral to membrane				ovary(1)	1						AGAGTGGGCCGTGTGGAGGTC	0.567													A	85051303	A	A	85051303	3	1	274	1	0	0	0	0	1	0	0	0	2203	1144	40	1	417	1	C2orf89	2	85051303	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08		85051303	158148070	13	19653											
MYO7B	4648	broad.mit.edu	37	chr2	128384614	128384614	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcaggtggtggacgccgcccGcctgcagtggccgctgctct	16	15	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr2:128384614G>A	uc002top.2	+	31	4255	c.4202G>A	c.(4201-4203)CGC>CAC	p.R1401H	MYO7B_uc002toq.1_Missense_Mutation_p.R254H|MYO7B_uc002tor.1_Missense_Mutation_p.R254H	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1401	FERM 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GACGCCGCCCGCCTGCAGTGG	0.637													A	128384614	A	A	128384614	3	1	274	1	0	0	0	0	1	0	0	0	10083	1087	38	1	4320	1	MYO7B	2	128384614	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	43333311	128384614	114814759	14	19654											
YSK4	80122	broad.mit.edu	37	chr2	135738842	135738842	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacaccatctcaggcaatgGcccaaaacggtttataatac	7	11	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr2:135738842G>A	uc002tue.1	-	9	3500	c.3469C>T	c.(3469-3471)CCA>TCA	p.P1157S	YSK4_uc002tuf.1_Missense_Mutation_p.P339S|YSK4_uc010fnc.1_Missense_Mutation_p.P291S|YSK4_uc010fnd.1_Missense_Mutation_p.P1044S|YSK4_uc010zbg.1_Missense_Mutation_p.P289S|YSK4_uc002tuh.3_Missense_Mutation_p.P885S|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1157	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCAGGCAATGGCCCAAAACGG	0.418													A	135738842	A	A	135738842	3	1	274	1	0	0	0	0	1	0	0	0	17492	1203	42	3	525	3	YSK4	2	135738842	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	7354228	135738842	107460531	15	19655											
FMNL2	114793	broad.mit.edu	37	chr2	153463859	153463859	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aatgtgtgtttcaggtttgtGgagaaaaacagcgctttgag	13	4	1	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr2:153463859G>A	uc002tye.2	+	10	1250	c.883G>A	c.(883-885)GGA>AGA	p.G295R		NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	295	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						TCAGGTTTGTGGAGAAAAACA	0.313													A	153463859	A	A	153463859	3	1	274	1	0	0	0	0	1	0	0	0	5952	1349	47	3	921	3	FMNL2	2	153463859	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	17725017	153463859	89735514	16	19656											
LOC200726	200726	broad.mit.edu	37	chr2	207509344	207509344	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaagagaaaatctcagcagcGcagccacagcacacaaggag	11	11	1	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr2:207509344G>A	uc010fuh.1	+	2	559	c.384G>A	c.(382-384)GCG>GCA	p.A128A		NM_001102659	NP_001096129			hypothetical protein LOC200726												0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.115)|Lung(261;0.133)		TCTCAGCAGCGCAGCCACAGC	0.488													A	207509344	A	A	207509344	2	1	274	1	0	0	0	0	0	0	0	1	8872	1074	38	1		1	LOC200726	2	207509344	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08	54045485	207509344	35690029	17	19657											
DNAH12	201625	broad.mit.edu	37	chr3	57493504	57493504	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	attcattatcttctcttctgCgtttctagtttgtattgata	5	7	5	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr3:57493504C>A	uc003dit.2	-	8	944	c.763G>T	c.(763-765)GCA>TCA	p.A255S	DNAH12_uc003diu.2_Missense_Mutation_p.A255S	NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	dynein heavy chain domain 2 isoform 1	255	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			pancreas(1)|skin(1)	2						TTCTCTTCTGCGTTTCTAGTT	0.333													A	57493504	A	A	57493504	3	1	274	1	0	0	0	0	1	0	0	0	4600	768	27	5	8766	5	DNAH12	3	57493504	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08		57493504	140528926	18	19658											
SEMA5B	54437	broad.mit.edu	37	chr3	122632727	122632727	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcctcccggctcttgcccaCgcagatgcggcccccgtggc	11	19	1	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr3:122632727C>T	uc003efz.1	-	15	2414	c.2110G>A	c.(2110-2112)GTG>ATG	p.V704M	SEMA5B_uc011bju.1_Missense_Mutation_p.V646M|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.V704M|SEMA5B_uc010hro.1_Missense_Mutation_p.V646M|SEMA5B_uc003efy.1_5'Flank	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	704	Extracellular (Potential).|TSP type-1 1.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CTCTTGCCCACGCAGATGCGG	0.657													T	122632727	T	T	122632727	3	4	274	1	0	0	0	0	1	0	0	0	14038	536	19	1	1381	1	SEMA5B	3	122632727	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	65139223	122632727	75389703	19	19659											
RTP1	132112	broad.mit.edu	37	chr3	186917605	186917605	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgcatccacgtggccagccGccaggacaaccggcggcacc	12	19	0	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr3:186917605G>A	uc003frg.2	+	2	569	c.539G>A	c.(538-540)CGC>CAC	p.R180H		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	180	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GTGGCCAGCCGCCAGGACAAC	0.682													A	186917605	A	A	186917605	3	1	274	1	0	0	0	0	1	0	0	0	13733	1087	38	1	545	1	RTP1	3	186917605	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	64284878	186917605	11104825	20	19660											
CCDC149	91050	broad.mit.edu	37	chr4	24878210	24878210	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtggcgctcccggagctgaTtggccatgagtttgtactgg	16	9	0	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr4:24878210T>C	uc011bxr.1	-	3	317	c.173A>G	c.(172-174)AAT>AGT	p.N58S	CCDC149_uc003grc.2_Missense_Mutation_p.N58S|CCDC149_uc003grb.2_RNA|CCDC149_uc003grd.2_Missense_Mutation_p.N58S|CCDC149_uc003gre.2_Missense_Mutation_p.N3S	NM_173463	NP_775734	B4DZG3	B4DZG3_HUMAN	coiled-coil domain containing 149 isoform 1	58											0		Breast(46;0.173)				CCGGAGCTGATTGGCCATGAG	0.517													C	24878210	C	C	24878210	3	2	274	1	0	0	0	0	1	0	0	0	2783	1493	52	4	1464	4	CCDC149	4	24878210	Missense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08		24878210	166276066	21	19661											
EPHA5	2044	broad.mit.edu	37	chr4	66217156	66217156	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	cttccagtacccgggaaagtCcaaagtcagacactttgcac	8	13	1	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr4:66217156C>A	uc003hcy.2	-	14	2652	c.2459G>T	c.(2458-2460)GGA>GTA	p.G820V	EPHA5_uc003hcx.2_Missense_Mutation_p.G752V|EPHA5_uc003hcz.2_Missense_Mutation_p.G798V|EPHA5_uc011cah.1_Missense_Mutation_p.G821V|EPHA5_uc011cai.1_Missense_Mutation_p.G799V|EPHA5_uc003hda.2_Missense_Mutation_p.G821V	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	820	Cytoplasmic (Potential).|Protein kinase.			G -> E (in Ref. 3; CAD97914).	cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CCGGGAAAGTCCAAAGTCAGA	0.443										TSP Lung(17;0.13)			A	66217156	A	A	66217156	3	1	274	1	0	0	0	0	1	0	0	0	5170	855	30	5	674	5	EPHA5	4	66217156	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	41338946	66217156	124937120	22	19662											
GK2	2712	broad.mit.edu	37	chr4	80328891	80328891	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tcacattgtcaagcatccaaCgaagttttactgcactgaag	7	10	2	1	rs147498656	byFrequency	TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr4:80328891C>A	uc003hlu.2	-	1	482	c.464G>T	c.(463-465)CGT>CTT	p.R155L		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	155					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						AAGCATCCAACGAAGTTTTAC	0.408													A	80328891	A	A	80328891	3	1	274	1	0	0	0	0	1	0	0	0	6421	536	19	5	1201	5	GK2	4	80328891	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	14111735	80328891	110825385	23	19663											
SPARCL1	8404	broad.mit.edu	37	chr4	88414795	88414795	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttcatgtactttttctcttTgctcctcaattttgaggtga	6	8	3	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr4:88414795T>C	uc010ikm.2	-	5	1729	c.1157A>G	c.(1156-1158)CAA>CGA	p.Q386R	SPARCL1_uc011cdc.1_Missense_Mutation_p.Q261R|SPARCL1_uc003hqs.3_Missense_Mutation_p.Q386R|SPARCL1_uc011cdd.1_Missense_Mutation_p.Q261R|SPARCL1_uc003hqt.2_Missense_Mutation_p.Q386R	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	386					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TTTTTCTCTTTGCTCCTCAAT	0.443													C	88414795	C	C	88414795	3	2	274	1	0	0	0	0	1	0	0	0	14995	1812	63	4	869	4	SPARCL1	4	88414795	Missense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08	8085904	88414795	102739481	24	19664											
FAM198B	51313	broad.mit.edu	37	chr4	159052126	159052126	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caggcatcttccttgcgaggTctgaatccacagcaatttgt	9	11	2	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr4:159052126T>C	uc003ipp.3	-	4	1616	c.1164A>G	c.(1162-1164)AGA>AGG	p.R388R	FAM198B_uc003ipq.3_Silent_p.R396R|FAM198B_uc003ipr.3_Silent_p.R388R	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	388	Extracellular (Potential).					Golgi membrane|integral to membrane					0						CCTTGCGAGGTCTGAATCCAC	0.413													C	159052126	C	C	159052126	2	2	274	1	0	0	0	0	0	0	0	1	5529	1664	58	4		4	FAM198B	4	159052126	Silent	SNP	T	TCGA-76-6656-01A-11D-1845-08	70637331	159052126	32102150	25	19665											
AHRR	57491	broad.mit.edu	37	chr5	428029	428029	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgttctgcattgcggcaccCgttctcctcccctccgcagc	8	19	2	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr5:428029C>T	uc003jav.2	+	9	926	c.882C>T	c.(880-882)CCC>CCT	p.P294P	AHRR_uc003jaw.2_Silent_p.P272P|AHRR_uc010isy.2_Silent_p.P122P|AHRR_uc010isz.2_Silent_p.P272P|AHRR_uc003jax.2_Silent_p.P35P|AHRR_uc003jay.2_Silent_p.P132P	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	276					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			TTGCGGCACCCGTTCTCCTCC	0.577													T	428029	T	T	428029	2	4	274	1	0	0	0	0	0	0	0	1	417	639	23	2		2	AHRR	5	428029	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08		428029	180487231	26	19666											
SLC6A19	340024	broad.mit.edu	37	chr5	1216774	1216774	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgtcattgggttccgcgccaCacagcgctacgacgactgct	11	15	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr5:1216774C>T	uc003jbw.3	+	7	1045	c.989C>T	c.(988-990)ACA>ATA	p.T330I		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	330	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TTCCGCGCCACACAGCGCTAC	0.607													T	1216774	T	T	1216774	3	4	274	1	0	0	0	0	1	0	0	0	14682	478	17	3	1015	3	SLC6A19	5	1216774	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	788745	1216774	179698486	27	19667											
GZMK	3003	broad.mit.edu	37	chr5	54329635	54329635	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctgtaaaggtgtcttccacGctatagtctctggaggtcat	10	9	4	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr5:54329635G>A	uc003jpl.1	+	5	720	c.676G>A	c.(676-678)GCT>ACT	p.A226T		NM_002104	NP_002095	P49863	GRAK_HUMAN	granzyme K precursor	226	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				TGTCTTCCACGCTATAGTCTC	0.453													A	54329635	A	A	54329635	3	1	274	1	0	0	0	0	1	0	0	0	6918	1087	38	1	694	1	GZMK	5	54329635	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	53112861	54329635	126585625	28	19668											
PIK3R1	5295	broad.mit.edu	37	chr5	67589138	67589138	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	attgtttttacaggaaagggGgaaataacaaattaatcaaa	8	3	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr5:67589138G>A	uc003jva.2	+	10	1686	c.1126G>A	c.(1126-1128)GGA>AGA	p.G376R	PIK3R1_uc003jvb.2_Missense_Mutation_p.G376R|PIK3R1_uc003jvc.2_Missense_Mutation_p.G76R|PIK3R1_uc003jvd.2_Missense_Mutation_p.G106R|PIK3R1_uc003jve.2_Missense_Mutation_p.G55R|PIK3R1_uc011crb.1_Missense_Mutation_p.G46R	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	376	SH2 1.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.G376R(3)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CAGGAAAGGGGGAAATAACAA	0.308			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			A	67589138	A	A	67589138	3	1	274	1	0	0	0	0	1	0	0	0	11918	1233	43	3	1290	3	PIK3R1	5	67589138	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	13259503	67589138	113326122	29	19669											
SLCO4C1	353189	broad.mit.edu	37	chr5	101599411	101599411	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcccatagcaacatcaatGtatatggttagcagttgtcc	7	10	2	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr5:101599411G>A	uc003knm.2	-	4	1163	c.876C>T	c.(874-876)TAC>TAT	p.Y292Y		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	292	Helical; Name=5; (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		CAACATCAATGTATATGGTTA	0.358													A	101599411	A	A	101599411	2	1	274	1	0	0	0	0	0	0	0	1	14730	1372	48	3		3	SLCO4C1	5	101599411	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08	34010273	101599411	79315849	30	19670											
PCDHB5	26167	broad.mit.edu	37	chr5	140516927	140516927	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gagcgcgacgcggccaagcaCaggctggtggtgctggtcaa	17	11	1	0	rs138297526		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr5:140516927C>G	uc003liq.2	+	1	2128	c.1911C>G	c.(1909-1911)CAC>CAG	p.H637Q		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	637	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGCCAAGCACAGGCTGGTGG	0.697													G	140516927	G	G	140516927	3	3	274	1	0	0	0	0	1	0	0	0	11545	477	17	5	1913	5	PCDHB5	5	140516927	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	38917516	140516927	40398333	31	19671											
PCDHB7	56129	broad.mit.edu	37	chr5	140554075	140554075	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgcgcgtgctggtgctggaCgccaacgacaactcgccctt	13	14	0	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr5:140554075C>T	uc003lit.2	+	1	1833	c.1659C>T	c.(1657-1659)GAC>GAT	p.D553D		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	553	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGCTGGACGCCAACGACA	0.721													T	140554075	T	T	140554075	2	4	274	1	0	0	0	0	0	0	0	1	11547	535	19	1		1	PCDHB7	5	140554075	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	37148	140554075	40361185	32	19672											
PCDHGA2	56113	broad.mit.edu	37	chr5	140720777	140720777	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttgtgggcgtggacggggttCgggctttcctgcagacctat	16	9	0	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr5:140720777C>T	uc003ljk.1	+	1	2424	c.2239C>T	c.(2239-2241)CGG>TGG	p.R747W	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Missense_Mutation_p.R747W|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	747	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGGGGTTCGGGCTTTCCT	0.627													T	140720777	T	T	140720777	3	4	274	1	0	0	0	0	1	0	0	0	11554	875	31	2	2241	2	PCDHGA2	5	140720777	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	166702	140720777	40194483	33	19673											
DNAH8	1769	broad.mit.edu	37	chr6	38850799	38850799	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	acaatattagaacaaattttTtgatagacaccattgcaaaa	4	6	0	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr6:38850799T>G	uc003ooe.1	+	52	7921	c.7321T>G	c.(7321-7323)TTG>GTG	p.L2441V		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AACAAATTTTTTGATAGACAC	0.323													G	38850799	G	G	38850799	3	3	274	1	0	0	0	0	1	0	0	0	4607	1838	64	5	7519	5	DNAH8	6	38850799	Missense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08		38850799	132264268	34	19674											
SLC35B2	347734	broad.mit.edu	37	chr6	44222858	44222858	+	Frame_Shift_Del	DEL	T	-	-													tctgcaccgatgacatcttaTaggcaaacagggcatcctgc							TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr6:44222858delT	uc003oxd.2	-	4	1020	c.884delA	c.(883-885)TATfs	p.Y295fs	SLC35B2_uc011dvt.1_Frame_Shift_Del_p.Y198fs|SLC35B2_uc011dvu.1_Frame_Shift_Del_p.Y162fs	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	295					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGACATCTTATAGGCAAACAG	0.532													-	44222858	-	-	44222858	7	5	274	1	0	1	0	1	0	0	0	0	14576	1406	49	0	418	0	SLC35B2	6	44222858	Frame_Shift_Del	DEL	T	TCGA-76-6656-01A-11D-1845-08	5372059	44222858	126892209	35	19675											
GSTA5	221357	broad.mit.edu	37	chr6	52699018	52699018	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catctctttcctctggttgaCatatgagcagaagaaggatc	9	9	2	4			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr6:52699018C>T	uc003pba.1	-	5	405	c.335G>A	c.(334-336)TGT>TAT	p.C112Y		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	112	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	CTCTGGTTGACATATGAGCAG	0.373													T	52699018	T	T	52699018	3	4	274	1	0	0	0	0	1	0	0	0	6834	478	17	3	345	3	GSTA5	6	52699018	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	8476160	52699018	118416049	36	19676											
MYO6	4646	broad.mit.edu	37	chr6	76545638	76545638	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	atacctgactgaatcctatgGaacaggtcaagatattgatg	9	7	1	4			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr6:76545638G>C	uc003pih.1	+	7	797	c.518G>C	c.(517-519)GGA>GCA	p.G173A	MYO6_uc003pig.1_Missense_Mutation_p.G173A|MYO6_uc003pii.1_Missense_Mutation_p.G173A	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	173	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GAATCCTATGGAACAGGTCAA	0.274													C	76545638	C	C	76545638	3	2	274	1	0	0	0	0	1	0	0	0	10081	1174	41	5	540	5	MYO6	6	76545638	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	23846620	76545638	94569429	37	19677											
SIM1	6492	broad.mit.edu	37	chr6	100896034	100896034	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccttacgcaaatggtgcgCgcagcgcaggtggaaggtgt	16	10	0	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr6:100896034C>T	uc003pqj.3	-	7	1045	c.838G>A	c.(838-840)GCG>ACG	p.A280T	SIM1_uc010kcu.2_Missense_Mutation_p.A280T	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	280	PAS 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AAATGGTGCGCGCAGCGCAGG	0.622													T	100896034	T	T	100896034	3	4	274	1	0	0	0	0	1	0	0	0	14323	768	27	1	1482	1	SIM1	6	100896034	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	24350396	100896034	70219033	38	19678											
ASCC3	10973	broad.mit.edu	37	chr6	101073206	101073206	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttggctggagaatggcttctAattgctgttgaaaagttgtg	13	4	1	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr6:101073206A>G	uc003pqk.2	-	30	4976	c.4647T>C	c.(4645-4647)ATT>ATC	p.I1549I		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1549	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		AATGGCTTCTAATTGCTGTTG	0.368													G	101073206	G	G	101073206	2	3	274	1	0	0	0	0	0	0	0	1	1033	358	13	4		4	ASCC3	6	101073206	Silent	SNP	A	TCGA-76-6656-01A-11D-1845-08	177172	101073206	70041861	39	19679											
SYNE1	23345	broad.mit.edu	37	chr6	152554981	152554981	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtccactggctatcaatgcGcgacagctcagagcgcagcg	12	13	2	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr6:152554981G>A	uc010kiw.2	-	112	21249	c.20647C>T	c.(20647-20649)CGC>TGC	p.R6883C	SYNE1_uc010kiv.2_Missense_Mutation_p.R1407C|SYNE1_uc003qos.3_Missense_Mutation_p.R1407C|SYNE1_uc003qot.3_Missense_Mutation_p.R6812C|SYNE1_uc003qou.3_Missense_Mutation_p.R6883C	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6883	Spectrin 21.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTATCAATGCGCGACAGCTCA	0.512										HNSCC(10;0.0054)			A	152554981	A	A	152554981	3	1	274	1	0	0	0	0	1	0	0	0	15442	1087	38	1	5959	1	SYNE1	6	152554981	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	51481775	152554981	18560086	40	19680											
PDE10A	10846	broad.mit.edu	37	chr6	165808689	165808689	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccaggatgtcccacaggaccGatgaaccatgtagacaaaaa	9	11	0	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr6:165808689G>A	uc003qun.2	-	16	1697	c.1456C>T	c.(1456-1458)CGG>TGG	p.R486W	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.R416W|PDE10A_uc003quo.2_Missense_Mutation_p.R496W	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	486					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CCACAGGACCGATGAACCATG	0.383													A	165808689	A	A	165808689	3	1	274	1	0	0	0	0	1	0	0	0	11630	1057	37	2	915	2	PDE10A	6	165808689	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	13253708	165808689	5306378	41	19681											
SDK1	221935	broad.mit.edu	37	chr7	4050739	4050739	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggccagtacagcgccgagaCaagcaggtgcgtgaatcccg	15	12	0	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr7:4050739C>A	uc003smx.2	+	15	2412	c.2273C>A	c.(2272-2274)ACA>AAA	p.T758K	SDK1_uc010kso.2_Missense_Mutation_p.T34K	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	758	Fibronectin type-III 1.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCGCCGAGACAAGCAGGTGC	0.597													A	4050739	A	A	4050739	3	1	274	1	0	0	0	0	1	0	0	0	13968	478	17	5	2331	5	SDK1	7	4050739	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08		4050739	155087924	42	19682											
SDK1	221935	broad.mit.edu	37	chr7	4189057	4189057	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gagtggcagacctactcctcGtccatcagccatgaggcgac	11	14	1	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr7:4189057G>A	uc003smx.2	+	30	4726	c.4587G>A	c.(4585-4587)TCG>TCA	p.S1529S	SDK1_uc010kso.2_Silent_p.S805S|SDK1_uc003smy.2_Silent_p.S16S	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1529	Fibronectin type-III 9.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCTACTCCTCGTCCATCAGCC	0.682													A	4189057	A	A	4189057	2	1	274	1	0	0	0	0	0	0	0	1	13968	1132	40	1		1	SDK1	7	4189057	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08	138318	4189057	154949606	43	19683											
FAM188B	84182	broad.mit.edu	37	chr7	30830978	30830978	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaaggcagaaaaccactgcCagcagccctccccatctgcc	8	17	1	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr7:30830978C>T	uc003tbt.2	+	5	938	c.861C>T	c.(859-861)GCC>GCT	p.A287A	FAM188B_uc010kwe.2_Silent_p.A258A	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	287											0						AAACCACTGCCAGCAGCCCTC	0.637													T	30830978	T	T	30830978	2	4	274	1	0	0	0	0	0	0	0	1	5515	581	21	3		3	FAM188B	7	30830978	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	26641921	30830978	128307685	44	19684											
EGFR	1956	broad.mit.edu	37	chr7	55220329	55220329	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caaccagtgtgctgcaggctGcacaggcccccgggagagcg	15	14	0	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr7:55220329G>A	uc003tqk.2	+	6	965	c.719G>A	c.(718-720)TGC>TAC	p.C240Y	EGFR_uc003tqh.2_Missense_Mutation_p.C240Y|EGFR_uc003tqi.2_Missense_Mutation_p.C240Y|EGFR_uc003tqj.2_Missense_Mutation_p.C240Y|EGFR_uc010kzg.1_Missense_Mutation_p.C195Y|EGFR_uc011kco.1_Missense_Mutation_p.C187Y|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	240	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GCTGCAGGCTGCACAGGCCCC	0.647		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			A	55220329	A	A	55220329	3	1	274	1	0	0	0	0	1	0	0	0	4967	1319	46	3	741	3	EGFR	7	55220329	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	24389351	55220329	103918334	45	19685											
PHKG1	5260	broad.mit.edu	37	chr7	56151084	56151084	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaggtcccggtgcacgatgTtgagtttgtgcaaggtgcag	15	8	1	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr7:56151084T>C	uc003trz.1	-	6	629	c.434A>G	c.(433-435)AAC>AGC	p.N145S	PSPH_uc003trj.2_Intron|PHKG1_uc003try.1_Missense_Mutation_p.N39S|PHKG1_uc011kdb.1_Missense_Mutation_p.N177S|PHKG1_uc011kdc.1_Missense_Mutation_p.N136S|PHKG1_uc011kdd.1_Missense_Mutation_p.N91S	NM_006213	NP_006204	Q16816	PHKG1_HUMAN	phosphorylase kinase gamma subunit 1	145	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			large_intestine(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GTGCACGATGTTGAGTTTGTG	0.527													C	56151084	C	C	56151084	3	2	274	1	0	0	0	0	1	0	0	0	11846	1725	60	4	749	4	PHKG1	7	56151084	Missense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08	930755	56151084	102987579	46	19686											
CALN1	83698	broad.mit.edu	37	chr7	71571179	71571179	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgatggccagctccacctcGcttggcatgtaccccaaaga	9	14	0	2	rs139754746		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr7:71571179G>A	uc003twa.3	-	3	746	c.219C>T	c.(217-219)AGC>AGT	p.S73S	CALN1_uc003twb.3_Silent_p.S115S|CALN1_uc003twc.3_Silent_p.S73S	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	73	EF-hand 2.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				GCTCCACCTCGCTTGGCATGT	0.592													A	71571179	A	A	71571179	2	1	274	1	0	0	0	0	0	0	0	1	2591	1078	38	1		1	CALN1	7	71571179	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08	15420095	71571179	87567484	47	19687											
KCND2	3751	broad.mit.edu	37	chr7	119915031	119915031	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgagtgcatctctgcttaCgatgaagaactggccttctt	9	11	2	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr7:119915031C>T	uc003vjj.1	+	1	1310	c.345C>T	c.(343-345)TAC>TAT	p.Y115Y		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	115	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					TCTCTGCTTACGATGAAGAAC	0.542													T	119915031	T	T	119915031	2	4	274	1	0	0	0	0	0	0	0	1	8019	547	19	1		1	KCND2	7	119915031	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	48343852	119915031	39223632	48	19688											
CCDC136	64753	broad.mit.edu	37	chr7	128445464	128445464	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcccaaacactgagtatgacGtcagcagagtctcagacttc	8	12	2	4			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr7:128445464G>A	uc003vnv.1	+	6	1201	c.834G>A	c.(832-834)ACG>ACA	p.T278T	CCDC136_uc003vnu.1_Silent_p.T316T|CCDC136_uc003vnw.1_Silent_p.T278T|CCDC136_uc003vnx.1_Silent_p.T94T|CCDC136_uc010llq.1_5'UTR|CCDC136_uc003vny.1_5'Flank	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	278	Glu-rich.					integral to membrane	protein binding			ovary(2)	2						TGAGTATGACGTCAGCAGAGT	0.502													A	128445464	A	A	128445464	2	1	274	1	0	0	0	0	0	0	0	1	2770	1132	40	1		1	CCDC136	7	128445464	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08	8530433	128445464	30693199	49	19689											
TRPV6	55503	broad.mit.edu	37	chr7	142570125	142570125	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacccccgcatatcactcacCgcaggaaccagcggtctccc	7	19	3	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr7:142570125C>T	uc003wbx.1	-	14	2111	c.1895G>A	c.(1894-1896)CGG>CAG	p.R632Q	TRPV6_uc003wbw.1_Missense_Mutation_p.R418Q|TRPV6_uc010lou.1_Missense_Mutation_p.R503Q	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	632	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					TATCACTCACCGCAGGAACCA	0.662													T	142570125	T	T	142570125	3	4	274	1	0	0	0	0	1	0	0	0	16597	666	23	2	290	2	TRPV6	7	142570125	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	14124661	142570125	16568538	50	19690											
MSR1	4481	broad.mit.edu	37	chr8	16012638	16012638	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcgatctcctttttcacccGggggtccaggaggaccttta	10	13	2	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr8:16012638G>A	uc003wwz.2	-	6	1031	c.833C>T	c.(832-834)CCG>CTG	p.P278L	MSR1_uc010lsu.2_Missense_Mutation_p.P296L|MSR1_uc003wxa.2_Missense_Mutation_p.P278L|MSR1_uc003wxb.2_Missense_Mutation_p.P278L|MSR1_uc011kxz.1_Missense_Mutation_p.P52L	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	278	Collagen-like.|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TTTTTCACCCGGGGGTCCAGG	0.398													A	16012638	A	A	16012638	3	1	274	1	0	0	0	0	1	0	0	0	9886	1116	39	2	590	2	MSR1	8	16012638	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08		16012638	130351384	51	19691											
PRDM14	63978	broad.mit.edu	37	chr8	70964463	70964463	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gggatgcaaaagatttaccaCagtacttgcatttgaagggc	11	7	0	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr8:70964463C>A	uc003xym.2	-	8	1767	c.1565G>T	c.(1564-1566)TGT>TTT	p.C522F		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	522	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			AGATTTACCACAGTACTTGCA	0.517													A	70964463	A	A	70964463	3	1	274	1	0	0	0	0	1	0	0	0	12455	478	17	5	154	5	PRDM14	8	70964463	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	54951825	70964463	75399559	52	19692											
MTDH	92140	broad.mit.edu	37	chr8	98731338	98731338	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgaatacctctaaaacccGtccaaaacaggaaaaagctt	6	10	1	1	rs143317071		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr8:98731338G>A	uc003yhz.2	+	10	1770	c.1442G>A	c.(1441-1443)CGT>CAT	p.R481H	MTDH_uc010mbf.2_RNA	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	481	Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			TCTAAAACCCGTCCAAAACAG	0.333													A	98731338	A	A	98731338	3	1	274	1	0	0	0	0	1	0	0	0	9917	1145	40	1	1480	1	MTDH	8	98731338	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	27766875	98731338	47632684	53	19693											
WISP1	8840	broad.mit.edu	37	chr8	134239690	134239690	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggctgtgtaccagccagagGcatccatgaacttcacactt	9	12	1	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr8:134239690G>A	uc003yub.2	+	5	917	c.841G>A	c.(841-843)GCA>ACA	p.A281T	WISP1_uc003yuc.2_Missense_Mutation_p.A194T|WISP1_uc010meb.2_Missense_Mutation_p.A109T|WISP1_uc010mec.2_Missense_Mutation_p.G129D|WISP1_uc010med.2_Missense_Mutation_p.A36T|WISP1_uc003yud.2_RNA	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	281	CTCK.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CCAGCCAGAGGCATCCATGAA	0.527													A	134239690	A	A	134239690	3	1	274	1	0	0	0	0	1	0	0	0	17369	1203	42	3	859	3	WISP1	8	134239690	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	35508352	134239690	12124332	54	19694											
KIAA0020	9933	broad.mit.edu	37	chr9	2837296	2837296	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcttgaactgctttacacccTttttcccaagttttgtgata	5	10	1	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr9:2837296T>C	uc003zhp.1	-	3	284	c.188A>G	c.(187-189)AAG>AGG	p.K63R	KIAA0020_uc010mhc.1_Missense_Mutation_p.K62R|KIAA0020_uc003zhq.1_Missense_Mutation_p.K63R	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	63						endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		CTTTACACCCTTTTTCCCAAG	0.388													C	2837296	C	C	2837296	3	2	274	1	0	0	0	0	1	0	0	0	8152	1609	56	4	1822	4	KIAA0020	9	2837296	Missense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08		2837296	138376135	55	19695											
FAM75C1	441452	broad.mit.edu	37	chr9	90536630	90536630	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttgatccccgtgagtgtgcGtcgatcctggcttgctgtca	12	12	1	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr9:90536630G>A	uc010mqi.2	+	4	1837	c.1808G>A	c.(1807-1809)CGT>CAT	p.R603H	FAM75C1_uc004apq.3_Missense_Mutation_p.R586H	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GTGAGTGTGCGTCGATCCTGG	0.512													A	90536630	A	A	90536630	3	1	274	1	0	0	0	0	1	0	0	0	5623	1145	40	1	1822	1	FAM75C1	9	90536630	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	87699334	90536630	50676801	56	19696											
BICD2	23299	broad.mit.edu	37	chr9	95481762	95481762	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actcagattctctgtgaggcGggtcaccttctcctgctgtt	10	12	4	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr9:95481762G>A	uc004aso.1	-	5	1222	c.1165C>T	c.(1165-1167)CGC>TGC	p.R389C	BICD2_uc004asp.1_Missense_Mutation_p.R389C	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	389	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						TCTGTGAGGCGGGTCACCTTC	0.647													A	95481762	A	A	95481762	3	1	274	1	0	0	0	0	1	0	0	0	1429	1116	39	2	1424	2	BICD2	9	95481762	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	4945132	95481762	45731669	57	19697											
SH2D3C	10044	broad.mit.edu	37	chr9	130507103	130507103	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gctcctggcctgctggctggAggtctcagtcgctgcccact	13	15	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr9:130507103A>G	uc004bsc.2	-	7	1682	c.1540T>C	c.(1540-1542)TCC>CCC	p.S514P	SH2D3C_uc010mxo.2_Missense_Mutation_p.S354P|SH2D3C_uc004bry.2_Missense_Mutation_p.S356P|SH2D3C_uc004brz.3_Missense_Mutation_p.S160P|SH2D3C_uc011mak.1_Missense_Mutation_p.S160P|SH2D3C_uc004bsa.2_Missense_Mutation_p.S357P|SH2D3C_uc004bsb.2_Missense_Mutation_p.S446P	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	514					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						TGCTGGCTGGAGGTCTCAGTC	0.622													G	130507103	G	G	130507103	3	3	274	1	0	0	0	0	1	0	0	0	14234	304	11	4	1066	4	SH2D3C	9	130507103	Missense_Mutation	SNP	A	TCGA-76-6656-01A-11D-1845-08	35025341	130507103	10706328	58	19698											
NTNG2	84628	broad.mit.edu	37	chr9	135042315	135042315	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaccacagatgagggccccAcctgggagttctacgcctgc	12	14	1	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr9:135042315A>C	uc004cbh.2	+	2	873	c.97A>C	c.(97-99)ACC>CCC	p.T33P		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	33					axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		TGAGGGCCCCACCTGGGAGTT	0.607													C	135042315	C	C	135042315	3	2	274	1	0	0	0	0	1	0	0	0	10705	159	6	5	99	5	NTNG2	9	135042315	Missense_Mutation	SNP	A	TCGA-76-6656-01A-11D-1845-08	4535212	135042315	6171116	59	19699											
COL5A1	1289	broad.mit.edu	37	chr9	137716532	137716532	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gccagccagctgctggacgaCgggaatggcgagaactacgt	15	11	0	1	rs149981025		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr9:137716532C>T	uc004cfe.2	+	62	5167	c.4785C>T	c.(4783-4785)GAC>GAT	p.D1595D	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1595	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGCTGGACGACGGGAATGGCG	0.627													T	137716532	T	T	137716532	2	4	274	1	0	0	0	0	0	0	0	1	3696	535	19	1		1	COL5A1	9	137716532	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	2674217	137716532	3496899	60	19700											
TET1	80312	broad.mit.edu	37	chr10	70332622	70332622	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agagactctaattggtgtacAaaatccctctttacttaaag	6	8	2	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr10:70332622A>G	uc001jok.3	+	2	1032	c.527A>G	c.(526-528)CAA>CGA	p.Q176R		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	176					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						ATTGGTGTACAAAATCCCTCT	0.433													G	70332622	G	G	70332622	3	3	274	1	0	0	0	0	1	0	0	0	15766	130	5	4	529	4	TET1	10	70332622	Missense_Mutation	SNP	A	TCGA-76-6656-01A-11D-1845-08		70332622	65202125	61	19701											
ATRNL1	26033	broad.mit.edu	37	chr10	117061383	117061383	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agttagtccaaatcaaaatgCgaggccgtgcaaaaagccat	9	9	1	0	rs140372621		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr10:117061383C>T	uc001lcg.2	+	17	3034	c.2648C>T	c.(2647-2649)GCG>GTG	p.A883V	ATRNL1_uc010qsm.1_Missense_Mutation_p.A58V|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	883	Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AATCAAAATGCGAGGCCGTGC	0.378													T	117061383	T	T	117061383	3	4	274	1	0	0	0	0	1	0	0	0	1207	768	27	1	2714	1	ATRNL1	10	117061383	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	46728761	117061383	18473364	62	19702											
HSPA12A	259217	broad.mit.edu	37	chr10	118434624	118434624	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatgaacttgtcaaagacgtCggtgcaccaccgagtgccat	11	11	1	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr10:118434624C>T	uc001lct.2	-	12	1801	c.1696G>A	c.(1696-1698)GAC>AAC	p.D566N	HSPA12A_uc001lcu.2_Missense_Mutation_p.D483N	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	566							ATP binding			ovary(1)	1				all cancers(201;0.0158)		TCAAAGACGTCGGTGCACCAC	0.622													T	118434624	T	T	118434624	3	4	274	1	0	0	0	0	1	0	0	0	7404	884	31	2	335	2	HSPA12A	10	118434624	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	1373241	118434624	17100123	63	19703											
TRIM21	6737	broad.mit.edu	37	chr11	4410895	4410895	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cattcttaccttccagtctgCtctctttattgcaatttcca	3	13	3	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr11:4410895C>A	uc001lyy.1	-	3	606	c.493G>T	c.(493-495)GCA>TCA	p.A165S		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	165	Potential.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		TTCCAGTCTGCTCTCTTTATT	0.507													A	4410895	A	A	4410895	3	1	274	1	0	0	0	0	1	0	0	0	16492	797	28	5	954	5	TRIM21	11	4410895	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08		4410895	130595621	64	19704											
OR51G1	79324	broad.mit.edu	37	chr11	4944754	4944754	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gacatgaagaggtgtacaacGcggggcagatgttcaccaaa	13	8	1	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr11:4944754G>A	uc010qyr.1	-	1	816	c.816C>T	c.(814-816)CGC>CGT	p.R272R		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGTGTACAACGCGGGGCAGAT	0.498													A	4944754	A	A	4944754	2	1	274	1	0	0	0	0	0	0	0	1	11098	1074	38	1		1	OR51G1	11	4944754	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08	533859	4944754	130061762	65	19705											
C11orf41	25758	broad.mit.edu	37	chr11	33566719	33566719	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaccccaccaacctggagatGcccagagcatccacgccacg	8	18	0	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr11:33566719G>A	uc001mup.3	+	2	2431	c.2307G>A	c.(2305-2307)ATG>ATA	p.M769I	C11orf41_uc001mun.1_Missense_Mutation_p.M769I	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	763						integral to membrane				ovary(2)	2						ACCTGGAGATGCCCAGAGCAT	0.592													A	33566719	A	A	33566719	3	1	274	1	0	0	0	0	1	0	0	0	1640	1319	46	3	2313	3	C11orf41	11	33566719	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	28621965	33566719	101439797	66	19706											
LRRC4C	57689	broad.mit.edu	37	chr11	40136459	40136459	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcatcctgagacggttccaTagtctctactgtgacggttg	10	11	2	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr11:40136459T>C	uc001mxa.1	-	2	3348	c.1384A>G	c.(1384-1386)ATG>GTG	p.M462V	LRRC4C_uc001mxc.1_Missense_Mutation_p.M458V|LRRC4C_uc001mxd.1_Missense_Mutation_p.M458V|LRRC4C_uc001mxb.1_Missense_Mutation_p.M458V	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	462					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GACGGTTCCATAGTCTCTACT	0.507													C	40136459	C	C	40136459	3	2	274	1	0	0	0	0	1	0	0	0	9008	1406	49	4	542	4	LRRC4C	11	40136459	Missense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08	6569740	40136459	94870057	67	19707											
INCENP	3619	broad.mit.edu	37	chr11	61895641	61895641	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agacagagccaccatggggaCgacggccccagggcccattc	13	15	0	2	rs61744797		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr11:61895641C>T	uc001nsw.1	+	2	210	c.8C>T	c.(7-9)ACG>ATG	p.T3M	INCENP_uc009ynv.2_Missense_Mutation_p.T3M|INCENP_uc009ynw.1_Missense_Mutation_p.T3M|INCENP_uc001nsx.1_Missense_Mutation_p.T3M	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	3					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						ACCATGGGGACGACGGCCCCA	0.567													T	61895641	T	T	61895641	3	4	274	1	0	0	0	0	1	0	0	0	7733	536	19	1	10	1	INCENP	11	61895641	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	21759182	61895641	73110875	68	19708											
RSF1	51773	broad.mit.edu	37	chr11	77413468	77413468	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagtagtctcttctagaacaTtggctgtagaacggttttct	9	8	3	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr11:77413468T>C	uc001oyn.2	-	6	926	c.806A>G	c.(805-807)AAT>AGT	p.N269S	RSF1_uc001oym.2_Missense_Mutation_p.N17S	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	269	Glu-rich.				CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			TTCTAGAACATTGGCTGTAGA	0.348													C	77413468	C	C	77413468	3	2	274	1	0	0	0	0	1	0	0	0	13699	1493	52	4	3563	4	RSF1	11	77413468	Missense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08	15517827	77413468	57593048	69	19709											
KCNJ5	3762	broad.mit.edu	37	chr11	128786516	128786516	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccagtacctccccagccccCcactgctggggggctgtgct	11	18	0	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr11:128786516C>T	uc001qet.2	+	3	1464	c.1150C>T	c.(1150-1152)CCA>TCA	p.P384S	KCNJ5_uc009zck.2_Missense_Mutation_p.P384S|KCNJ5_uc001qew.2_Missense_Mutation_p.P384S	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	384	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CCCCAGCCCCCCACTGCTGGG	0.627													T	128786516	T	T	128786516	3	4	274	1	0	0	0	0	1	0	0	0	8054	623	22	3	1156	3	KCNJ5	11	128786516	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	51373048	128786516	6220000	70	19710											
LGR5	8549	broad.mit.edu	37	chr12	71977624	71977624	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacgggagtctccagtgccGtgctggctggtgtggatgcg	17	10	2	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr12:71977624G>A	uc001swl.2	+	18	1882	c.1834G>A	c.(1834-1836)GTG>ATG	p.V612M	LGR5_uc001swm.2_Missense_Mutation_p.V588M|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	612	Helical; Name=2; (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						CTCCAGTGCCGTGCTGGCTGG	0.507													A	71977624	A	A	71977624	3	1	274	1	0	0	0	0	1	0	0	0	8757	1145	40	1	1904	1	LGR5	12	71977624	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08		71977624	61874271	71	19711											
CCDC41	51134	broad.mit.edu	37	chr12	94761707	94761707	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tccaaatctgctaatctgttCtcgagttctaacctaaaaca	4	11	4	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr12:94761707C>G	uc001tdd.2	-	11	1792	c.1206G>C	c.(1204-1206)GAG>GAC	p.E402D	CCDC41_uc001tde.2_Missense_Mutation_p.E402D|CCDC41_uc009zsw.1_RNA	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	394	Potential.										0						CTAATCTGTTCTCGAGTTCTA	0.343													G	94761707	G	G	94761707	3	3	274	1	0	0	0	0	1	0	0	0	2813	912	32	5	927	5	CCDC41	12	94761707	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	22784083	94761707	39090188	72	19712											
RBM19	9904	broad.mit.edu	37	chr12	114282581	114282581	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgggtgctgtgacacagggCgttgaaggctctctgcagag	17	8	1	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr12:114282581C>T	uc009zwi.2	-	23	2821	c.2677G>A	c.(2677-2679)GCC>ACC	p.A893T	RBM19_uc001tvn.3_Missense_Mutation_p.A893T|RBM19_uc001tvm.2_Missense_Mutation_p.A893T	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	893	RRM 6.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TGACACAGGGCGTTGAAGGCT	0.642													T	114282581	T	T	114282581	3	4	274	1	0	0	0	0	1	0	0	0	13121	768	27	1	213	1	RBM19	12	114282581	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	19520874	114282581	19569314	73	19713											
RNF17	56163	broad.mit.edu	37	chr13	25417989	25417989	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aaatcctgtgtctgcaaaatCtctacctaatgagaattttc	5	9	2	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr13:25417989C>T	uc001upr.2	+	20	2752	c.2711C>T	c.(2710-2712)TCT>TTT	p.S904F	RNF17_uc010tdd.1_Missense_Mutation_p.S763F|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.S904F|RNF17_uc001ups.2_Missense_Mutation_p.S843F|RNF17_uc010aac.2_Missense_Mutation_p.S102F|RNF17_uc010aad.2_5'UTR	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	904					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TCTGCAAAATCTCTACCTAAT	0.323													T	25417989	T	T	25417989	3	4	274	1	0	0	0	0	1	0	0	0	13461	913	32	3	2789	3	RNF17	13	25417989	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08		25417989	89751889	74	19714											
SHISA2	387914	broad.mit.edu	37	chr13	26621160	26621160	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaccccaagatgataaaggCgacaaacacggagccaacaa	10	11	0	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr13:26621160C>T	uc001uqm.1	-	2	464	c.379G>A	c.(379-381)GCC>ACC	p.A127T		NM_001007538	NP_001007539	Q6UWI4	SHSA2_HUMAN	shisa homolog 2 precursor	127	Helical; (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2						ATGATAAAGGCGACAAACACG	0.542													T	26621160	T	T	26621160	3	4	274	1	0	0	0	0	1	0	0	0	14280	768	27	1	512	1	SHISA2	13	26621160	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	1203171	26621160	88548718	75	19715											
C13orf18	80183	broad.mit.edu	37	chr13	46937309	46937309	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttcacatcatggtaagtaCgtgtttcagtcactgggctg	10	9	4	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr13:46937309C>T	uc010acl.2	-	6	1471	c.866G>A	c.(865-867)CGT>CAT	p.R289H	C13orf18_uc001vbf.3_Missense_Mutation_p.R222H|C13orf18_uc001vbg.3_Missense_Mutation_p.R17H|C13orf18_uc010tfz.1_Missense_Mutation_p.R132H|C13orf18_uc010acm.2_Missense_Mutation_p.R154H|C13orf18_uc010acn.2_Missense_Mutation_p.R74H|C13orf18_uc001vbe.3_Missense_Mutation_p.R289H|C13orf18_uc001vbh.3_Missense_Mutation_p.R289H|C13orf18_uc001vbi.3_Missense_Mutation_p.R132H|C13orf18_uc010aco.1_Missense_Mutation_p.R289H	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	289											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		ATGGTAAGTACGTGTTTCAGT	0.393													T	46937309	T	T	46937309	3	4	274	1	0	0	0	0	1	0	0	0	1720	536	19	1	1162	1	C13orf18	13	46937309	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	20316149	46937309	68232569	76	19716											
PCDH17	27253	broad.mit.edu	37	chr13	58299189	58299189	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ctgacagtcaatatctgtcaCctagtaagcaaccaagagac	7	11	3	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr13:58299189C>G	uc001vhq.1	+	4	4133	c.3241C>G	c.(3241-3243)CCT>GCT	p.P1081A	PCDH17_uc010aec.1_Missense_Mutation_p.P1080A|PCDH17_uc001vhr.1_Missense_Mutation_p.P170A	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1081	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATATCTGTCACCTAGTAAGCA	0.527													G	58299189	G	G	58299189	3	3	274	1	0	0	0	0	1	0	0	0	11512	507	18	5	3255	5	PCDH17	13	58299189	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	11361880	58299189	56870689	77	19717											
DACH1	1602	broad.mit.edu	37	chr13	72147083	72147083	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcattgccatggtgacagaTgctggaggtaggctgacagg	15	8	1	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr13:72147083T>C	uc010thn.1	-	5	1611	c.1188A>G	c.(1186-1188)GCA>GCG	p.A396A	DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	448					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TGGTGACAGATGCTGGAGGTA	0.473													C	72147083	C	C	72147083	2	2	274	1	0	0	0	0	0	0	0	1	4220	1451	51	4		4	DACH1	13	72147083	Silent	SNP	T	TCGA-76-6656-01A-11D-1845-08	13847894	72147083	43022795	78	19718											
ARID4A	5926	broad.mit.edu	37	chr14	58771705	58771705	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cacacaattggtacaagatgAccaagtaaagggtcctttaa	8	8	0	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr14:58771705A>G	uc001xdp.2	+	4	415	c.161A>G	c.(160-162)GAC>GGC	p.D54G	ARID4A_uc010apf.1_RNA|ARID4A_uc001xdo.2_Missense_Mutation_p.D54G|ARID4A_uc001xdq.2_Missense_Mutation_p.D54G	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	54					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						GTACAAGATGACCAAGTAAAG	0.279													G	58771705	G	G	58771705	3	3	274	1	0	0	0	0	1	0	0	0	919	275	10	4	171	4	ARID4A	14	58771705	Missense_Mutation	SNP	A	TCGA-76-6656-01A-11D-1845-08		58771705	48577835	79	19719											
SYNE2	23224	broad.mit.edu	37	chr14	64450574	64450574	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tcaacagatatgtcagtagaActtcctgaaaattataatca	5	7	3	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr14:64450574A>G	uc001xgm.2	+	18	2351	c.2121A>G	c.(2119-2121)GAA>GAG	p.E707E	SYNE2_uc001xgl.2_Silent_p.E707E	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	707	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGTCAGTAGAACTTCCTGAAA	0.259													G	64450574	G	G	64450574	2	3	274	1	0	0	0	0	0	0	0	1	15443	40	2	4		4	SYNE2	14	64450574	Silent	SNP	A	TCGA-76-6656-01A-11D-1845-08	5678869	64450574	42898966	80	19720											
ATP10A	57194	broad.mit.edu	37	chr15	26026298	26026298	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgtccgcagggaagatttcGttgcagcgaagacgcacaaa	12	9	0	2	rs145190957	byFrequency	TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr15:26026298G>A	uc010ayu.2	-	2	628	c.522C>T	c.(520-522)AAC>AAT	p.N174N		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	174	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGAAGATTTCGTTGCAGCGAA	0.488													A	26026298	A	A	26026298	2	1	274	1	0	0	0	0	0	0	0	1	1116	1136	40	1		1	ATP10A	15	26026298	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08		26026298	76505094	81	19721											
SPINT1	6692	broad.mit.edu	37	chr15	41146113	41146113	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggcagctctggggctcaggCgactttcccccagggtgagt	15	12	2	1	rs145193299		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr15:41146113C>T	uc001zna.2	+	5	1151	c.947C>T	c.(946-948)GCG>GTG	p.A316V	SPINT1_uc001znb.2_Intron|SPINT1_uc001znc.2_Intron|SPINT1_uc010ucs.1_Missense_Mutation_p.A316V	NM_181642	NP_857593	O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	316						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GGGGCTCAGGCGACTTTCCCC	0.592													T	41146113	T	T	41146113	3	4	274	1	0	0	0	0	1	0	0	0	15067	768	27	1	961	1	SPINT1	15	41146113	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	15119815	41146113	61385279	82	19722											
GABPB1	2553	broad.mit.edu	37	chr15	50593063	50593063	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tagctaatactgatgtagaaGagtttccaaactgaacagca	8	7	0	4			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr15:50593063G>T	uc001zyb.2	-	6	1080	c.656C>A	c.(655-657)TCT>TAT	p.S219Y	GABPB1_uc001zya.2_Missense_Mutation_p.S207Y|GABPB1_uc010ufg.1_Missense_Mutation_p.S143Y|GABPB1_uc001zyc.2_Missense_Mutation_p.S207Y|GABPB1_uc001zyd.2_Missense_Mutation_p.S207Y|GABPB1_uc001zye.2_Missense_Mutation_p.S219Y|GABPB1_uc001zyf.2_Missense_Mutation_p.S207Y	NM_005254	NP_005245	Q06547	GABP1_HUMAN	GA binding protein transcription factor, beta	219					positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)	1						TGATGTAGAAGAGTTTCCAAA	0.363													T	50593063	T	T	50593063	3	4	274	1	0	0	0	0	1	0	0	0	6158	942	33	5	595	5	GABPB1	15	50593063	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	9446950	50593063	51938329	83	19723											
USP7	7874	broad.mit.edu	37	chr16	8998407	8998407	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaatatcatggtcggtgaccGcctgtaaaacttcacctgca	9	11	2	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr16:8998407G>A	uc002czl.2	-	15	1788	c.1589C>T	c.(1588-1590)GCG>GTG	p.A530V	USP7_uc010uyk.1_Missense_Mutation_p.A431V|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.A431V|USP7_uc002czk.2_Missense_Mutation_p.A514V|USP7_uc010uyl.1_Intron	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	530					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						GTCGGTGACCGCCTGTAAAAC	0.502													A	8998407	A	A	8998407	3	1	274	1	0	0	0	0	1	0	0	0	17085	1087	38	1	1787	1	USP7	16	8998407	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08		8998407	81356346	84	19724											
ERCC4	2072	broad.mit.edu	37	chr16	14029049	14029049	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gaccgaacatgttcccagctGagagactatatcactcttgg	9	11	2	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr16:14029049G>A	uc002dce.2	+	8	1269	c.1260G>A	c.(1258-1260)CTG>CTA	p.L420L	ERCC4_uc010uyz.1_5'UTR	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	420					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						GTTCCCAGCTGAGAGACTATA	0.403			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				A	14029049	A	A	14029049	2	1	274	1	0	0	0	0	0	0	0	1	5215	1277	45	3		3	ERCC4	16	14029049	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08	5030642	14029049	76325704	85	19725											
CNOT1	23019	broad.mit.edu	37	chr16	58587731	58587731	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ataaagtgactgatagaagcCaaatgctgacaatactgggg	11	6	0	4			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr16:58587731C>T	uc002env.2	-	22	3218	c.2925G>A	c.(2923-2925)TTG>TTA	p.L975L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.L970L|CNOT1_uc002enx.2_Silent_p.L975L|CNOT1_uc002enz.1_Silent_p.L404L|CNOT1_uc010vik.1_5'Flank	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	975					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGATAGAAGCCAAATGCTGAC	0.368													T	58587731	T	T	58587731	2	4	274	1	0	0	0	0	0	0	0	1	3617	593	21	3		3	CNOT1	16	58587731	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	44558682	58587731	31767022	86	19726											
PIK3R5	23533	broad.mit.edu	37	chr17	8791674	8791674	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttgggctggggcagggagCgggagcgctgggcccgggaa	23	8	0	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr17:8791674C>T	uc002glt.2	-	10	1497	c.1430G>A	c.(1429-1431)CGC>CAC	p.R477H	PIK3R5_uc010vuz.1_Missense_Mutation_p.R477H|PIK3R5_uc002glu.3_Missense_Mutation_p.R91H|PIK3R5_uc010coa.1_3'UTR|PIK3R5_uc010cob.1_Missense_Mutation_p.R91H	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	477					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GGGCAGGGAGCGGGAGCGCTG	0.721													T	8791674	T	T	8791674	3	4	274	1	0	0	0	0	1	0	0	0	11922	768	27	1	1252	1	PIK3R5	17	8791674	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08		8791674	72403536	87	19727											
MYH13	8735	broad.mit.edu	37	chr17	10215249	10215249	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgcagatttttgttctctcGcctcagtgtctctaactggt	8	10	3	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr17:10215249G>A	uc002gmk.1	-	32	4600	c.4510C>T	c.(4510-4512)CGA>TGA	p.R1504*		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1504	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TTGTTCTCTCGCCTCAGTGTC	0.542													A	10215249	A	A	10215249	4	1	274	1	0	0	0	0	0	1	0	0	10032	1095	38	1	1346	1	MYH13	17	10215249	Nonsense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	1423575	10215249	70979961	88	19728											
KRT35	3886	broad.mit.edu	37	chr17	39637207	39637207	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccactgagcaggcagagaaaCttctggccacaggggagaga	14	10	1	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr17:39637207C>A	uc002hws.2	-	1	186	c.143G>T	c.(142-144)AGT>ATT	p.S48I		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	48	Head.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				GGCAGAGAAACTTCTGGCCAC	0.622													A	39637207	A	A	39637207	3	1	274	1	0	0	0	0	1	0	0	0	8472	565	20	5	1252	5	KRT35	17	39637207	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	29421958	39637207	41558003	89	19729											
CYTH1	9267	broad.mit.edu	37	chr17	76705733	76705733	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caccatgccactctcctaccTgaatgtcagccagcagctcc	6	18	2	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr17:76705733T>C	uc002jvw.2	-	2	175	c.104A>G	c.(103-105)CAG>CGG	p.Q35R	CYTH1_uc010wtw.1_5'UTR|CYTH1_uc010wtx.1_5'UTR	NM_017456	NP_059430	Q15438	CYH1_HUMAN	cytohesin 1 isoform 2	35	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						CTCTCCTACCTGAATGTCAGC	0.388													C	76705733	C	C	76705733	3	2	274	1	0	0	0	0	1	0	0	0	4203	1594	55	4	1140	4	CYTH1	17	76705733	Missense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08	37068526	76705733	4489477	90	19730											
ZNF556	80032	broad.mit.edu	37	chr19	2878077	2878077	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaaagtctataaatgtgaaaCgtgtgggaaaacgtatggtt	12	3	1	1	rs139830711	byFrequency	TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:2878077C>T	uc002lwp.1	+	4	1208	c.1121C>T	c.(1120-1122)ACG>ATG	p.T374M	ZNF556_uc002lwq.2_Missense_Mutation_p.T373M	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	374	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAATGTGAAACGTGTGGGAAA	0.483													T	2878077	T	T	2878077	3	4	274	1	0	0	0	0	1	0	0	0	17984	536	19	1	1135	1	ZNF556	19	2878077	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08		2878077	56250906	91	19731											
C19orf28	126321	broad.mit.edu	37	chr19	3557226	3557226	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggcccagcagcagcagcagcCccgcgccgcgggagctgtag	16	16	0	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:3557226C>T	uc002lxz.2	-	1	346	c.176G>A	c.(175-177)GGG>GAG	p.G59E	C19orf28_uc002lxw.2_Missense_Mutation_p.G59E|C19orf28_uc002lxx.2_Missense_Mutation_p.G59E|C19orf28_uc002lxy.2_Missense_Mutation_p.G59E	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	59	Helical; (Potential).				transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCAGCAGCCCCGCGCCGCG	0.726													T	3557226	T	T	3557226	3	4	274	1	0	0	0	0	1	0	0	0	1917	623	22	3	1513	3	C19orf28	19	3557226	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	679149	3557226	55571757	92	19732											
ATCAY	85300	broad.mit.edu	37	chr19	3918804	3918804	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctcgttctctctgtccacagCgcgaggccccagccggagtt	11	16	2	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:3918804C>T	uc002lyy.3	+	11	1432	c.1002C>T	c.(1000-1002)AGC>AGT	p.S334S	ATCAY_uc010xhz.1_Silent_p.S340S|ATCAY_uc010dts.2_Silent_p.S91S	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	334					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		CTGTCCACAGCGCGAGGCCCC	0.612													T	3918804	T	T	3918804	2	4	274	1	0	0	0	0	0	0	0	1	1077	782	27	1		1	ATCAY	19	3918804	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	361578	3918804	55210179	93	19733											
FUT3	2525	broad.mit.edu	37	chr19	5844141	5844141	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaacttgtaccgggacagcGtctccatcatggtccccttg	10	13	2	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:5844141G>A	uc002mdk.2	-	2	807	c.710C>T	c.(709-711)ACG>ATG	p.T237M	FUT3_uc002mdm.2_Missense_Mutation_p.T237M|FUT3_uc002mdj.2_Missense_Mutation_p.T237M|FUT3_uc002mdl.2_Missense_Mutation_p.T237M	NM_001097641	NP_001091110	P21217	FUT3_HUMAN	fucosyltransferase 3	237	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity				0						CCGGGACAGCGTCTCCATCAT	0.622													A	5844141	A	A	5844141	3	1	274	1	0	0	0	0	1	0	0	0	6105	1145	40	1	379	1	FUT3	19	5844141	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	1925337	5844141	53284842	94	19734											
TNFSF14	8740	broad.mit.edu	37	chr19	6669943	6669943	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	acggccagcccggcccccatCagcaacagcaagagacccag	10	18	1	1	rs140577063		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:6669943C>T	uc002mfk.1	-	2	520	c.138G>A	c.(136-138)CTG>CTA	p.L46L	TNFSF14_uc002mfj.1_Intron	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	46	Helical; Signal-anchor for type II membrane protein; (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						CGGCCCCCATCAGCAACAGCA	0.662													T	6669943	T	T	6669943	2	4	274	1	0	0	0	0	0	0	0	1	16304	813	29	3		3	TNFSF14	19	6669943	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	825802	6669943	52459040	95	19735											
MUC16	94025	broad.mit.edu	37	chr19	9047128	9047128	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ttgggagttgtcctgggaacCattgtgttggtctctgcagg	15	7	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:9047128C>G	uc002mkp.2	-	5	34707	c.34503G>C	c.(34501-34503)ATG>ATC	p.M11501I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11503	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCTGGGAACCATTGTGTTGG	0.507													G	9047128	G	G	9047128	3	3	274	1	0	0	0	0	1	0	0	0	9973	594	21	5	9340	5	MUC16	19	9047128	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	2377185	9047128	50081855	96	19736											
MUC16	94025	broad.mit.edu	37	chr19	9082859	9082859	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	catgctctctgaggcatatcTagggtcccctgttcctgaag	10	12	2	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:9082859T>A	uc002mkp.2	-	1	9160	c.8956A>T	c.(8956-8958)AGA>TGA	p.R2986*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2987	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGGCATATCTAGGGTCCCCT	0.498													A	9082859	A	A	9082859	4	1	274	1	0	0	0	0	0	1	0	0	9973	1530	53	5	34903	5	MUC16	19	9082859	Nonsense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08	35731	9082859	50046124	97	19737											
NOTCH3	4854	broad.mit.edu	37	chr19	15289676	15289676	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcagcccacccccaggaccCgggctaggacggcactggcc	13	18	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:15289676C>T	uc002nan.2	-	23	3871	c.3795G>A	c.(3793-3795)CCG>CCA	p.P1265P	NOTCH3_uc002nao.1_Silent_p.P1213P	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1265	Extracellular (Potential).|EGF-like 32.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CCCCAGGACCCGGGCTAGGAC	0.647													T	15289676	T	T	15289676	2	4	274	1	0	0	0	0	0	0	0	1	10550	639	23	2		2	NOTCH3	19	15289676	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	6206817	15289676	43839307	98	19738											
IL12RB1	3594	broad.mit.edu	37	chr19	18180414	18180414	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcaggtggcaaggcccccGtcctggcccacaggctgcca	13	17	0	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:18180414G>A	uc002nhw.1	-	10	1195	c.1131C>T	c.(1129-1131)GAC>GAT	p.D377D	IL12RB1_uc010xqb.1_Silent_p.D377D|IL12RB1_uc002nhx.1_Silent_p.D417D	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	377	Extracellular (Potential).|Fibronectin type-III 4.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						CAAGGCCCCCGTCCTGGCCCA	0.627													A	18180414	A	A	18180414	2	1	274	1	0	0	0	0	0	0	0	1	7626	1136	40	1		1	IL12RB1	19	18180414	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08	2890738	18180414	40948569	99	19739											
ZNF91	7644	broad.mit.edu	37	chr19	23544856	23544856	+	Frame_Shift_Del	DEL	G	-	-													aattctcttatgtttagcaaGggttgaagaatggctaaaag							TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:23544856delG	uc002nre.2	-	4	1038	c.925delC	c.(925-927)CTTfs	p.L309fs	ZNF91_uc010xrj.1_Frame_Shift_Del_p.L277fs	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	309	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGTTTAGCAAGGGTTGAAGAA	0.403													-	23544856	-	-	23544856	7	5	274	1	0	1	0	1	0	0	0	0	18197	1000	35	0	2654	0	ZNF91	19	23544856	Frame_Shift_Del	DEL	G	TCGA-76-6656-01A-11D-1845-08	5364442	23544856	35584127	100	19740											
GPATCH1	55094	broad.mit.edu	37	chr19	33604693	33604693	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcaactttagttggcttacCaagagtgaagcgtgacaagt	10	7	1	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:33604693C>T	uc002nug.1	+	14	2227	c.1913C>T	c.(1912-1914)CCA>CTA	p.P638L	GPATCH1_uc002nuh.1_Missense_Mutation_p.P15L	NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	638						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					GTTGGCTTACCAAGAGTGAAG	0.418													T	33604693	T	T	33604693	3	4	274	1	0	0	0	0	1	0	0	0	6590	594	21	3	1967	3	GPATCH1	19	33604693	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	10059837	33604693	25524290	101	19741											
WDR88	126248	broad.mit.edu	37	chr19	33666419	33666421	+	In_Frame_Del	DEL	TCA	-	-													tgccagcagatacttcatcgTcatcatcatcatcggaaagg							TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:33666419_33666421delTCA	uc002nui.2	+	11	1438_1440	c.1360_1362delTCA	c.(1360-1362)TCAdel	p.S458del		NM_173479	NP_775750	Q6ZMY6	WDR88_HUMAN	PQQ repeat and WD repeat domain containing	458	Poly-Ser.									ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)					TACTTCATCGTCATCATCATCAT	0.527													-	33666421	-	-	33666419	7	5	274	1	0	1	0	1	0	0	0	0	17332	1667	58	0	1402	0	WDR88	19	33666419	In_Frame_Del	DEL	TCA	TCGA-76-6656-01A-11D-1845-08	61726	33666419	25462564	102	19742											
CYP2F1	1572	broad.mit.edu	37	chr19	41622139	41622139	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tactcctgctcctggctctcGtctgtctgctcctgacccta	7	17	3	1	rs142026539		TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:41622139G>A	uc002opu.1	+	2	102	c.46G>A	c.(46-48)GTC>ATC	p.V16I	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_Missense_Mutation_p.V16I|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	16					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						CCTGGCTCTCGTCTGTCTGCT	0.577													A	41622139	A	A	41622139	3	1	274	1	0	0	0	0	1	0	0	0	4171	1145	40	1	48	1	CYP2F1	19	41622139	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	7955720	41622139	17506844	103	19743											
NLRP8	126205	broad.mit.edu	37	chr19	56477731	56477731	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgagatccccccggtgccGtctgcagtgtctcaggtgag	14	13	2	2	rs142437909	by1000genomes	TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr19:56477731G>A	uc002qmh.2	+	5	2437	c.2366G>A	c.(2365-2367)CGT>CAT	p.R789H	NLRP8_uc010etg.2_Missense_Mutation_p.R789H	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	789						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CCCCGGTGCCGTCTGCAGTGT	0.547													A	56477731	A	A	56477731	3	1	274	1	0	0	0	0	1	0	0	0	10483	1145	40	1	2384	1	NLRP8	19	56477731	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	14855592	56477731	2651252	104	19744											
R3HDML	140902	broad.mit.edu	37	chr20	42965819	42965819	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcccctgctgcccagcaccGtgggcctggcaggcctgctc	13	18	0	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr20:42965819G>A	uc002xls.1	+	1	194	c.22G>A	c.(22-24)GTG>ATG	p.V8M		NM_178491	NP_848586	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like precursor	8						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			GCCCAGCACCGTGGGCCTGGC	0.647													A	42965819	A	A	42965819	3	1	274	1	0	0	0	0	1	0	0	0	12889	1145	40	1	24	1	R3HDML	20	42965819	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08		42965819	20059701	105	19745											
SLC17A9	63910	broad.mit.edu	37	chr20	61595026	61595026	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcgaggagaccttccccgaCgccaaggtgagtcgggggct	15	12	0	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr20:61595026C>T	uc002yea.3	+	7	1000	c.816C>T	c.(814-816)GAC>GAT	p.D272D	SLC17A9_uc002ydz.3_Silent_p.D266D|SLC17A9_uc011aap.1_Silent_p.D292D	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	272					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						CCTTCCCCGACGCCAAGGTGA	0.667													T	61595026	T	T	61595026	2	4	274	1	0	0	0	0	0	0	0	1	14424	535	19	1		1	SLC17A9	20	61595026	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	18629207	61595026	1430494	106	19746											
PWP2	5822	broad.mit.edu	37	chr21	45545899	45545899	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttgctgttctaggaattttTgaaccgaagaaaaatgacag	9	5	1	3			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr21:45545899T>C	uc002zeb.2	+	16	2063	c.1973T>C	c.(1972-1974)TTG>TCG	p.L658S		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	658						cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		TAGGAATTTTTGAACCGAAGA	0.537													C	45545899	C	C	45545899	3	2	274	1	0	0	0	0	1	0	0	0	12844	1821	63	4	2035	4	PWP2	21	45545899	Missense_Mutation	SNP	T	TCGA-76-6656-01A-11D-1845-08		45545899	2583996	107	19747											
C21orf29	54084	broad.mit.edu	37	chr21	45919792	45919792	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggtggggaggctgtgcacCgccacgaagccctcgtagcc	15	14	0	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr21:45919792C>T	uc002zfe.1	-	12	1950	c.1884G>A	c.(1882-1884)GCG>GCA	p.A628A	C21orf29_uc010gpv.1_Silent_p.A560A	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	628	EAR 7.				cell adhesion	extracellular region	structural molecule activity				0						GGCTGTGCACCGCCACGAAGC	0.706													T	45919792	T	T	45919792	2	4	274	1	0	0	0	0	0	0	0	1	2124	639	23	2		2	C21orf29	21	45919792	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	373893	45919792	2210103	108	19748											
ZNF280B	140883	broad.mit.edu	37	chr22	22843649	22843649	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagatgagctcagcatcttcGtcatctacttgtttggtttc	8	9	4	2			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr22:22843649G>A	uc002zwc.1	-	4	851	c.75C>T	c.(73-75)GAC>GAT	p.D25D	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	25					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		CAGCATCTTCGTCATCTACTT	0.378													A	22843649	A	A	22843649	2	1	274	1	0	0	0	0	0	0	0	1	17812	1136	40	1		1	ZNF280B	22	22843649	Silent	SNP	G	TCGA-76-6656-01A-11D-1845-08		22843649	28460917	109	19749											
SCUBE1	80274	broad.mit.edu	37	chr22	43603579	43603579	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctccgaggcgtacaggcgCccatcgcgcacgatgtcctc	11	16	1	0			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr22:43603579C>T	uc003bdt.1	-	21	2863	c.2775G>A	c.(2773-2775)GGG>GGA	p.G925G		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	925					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CGTACAGGCGCCCATCGCGCA	0.597													T	43603579	T	T	43603579	2	4	274	1	0	0	0	0	0	0	0	1	13944	726	26	3		3	SCUBE1	22	43603579	Silent	SNP	C	TCGA-76-6656-01A-11D-1845-08	20759930	43603579	7700987	110	19750											
MOV10L1	54456	broad.mit.edu	37	chr22	50588117	50588117	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggaatgcctcattcctctgGggctgatgtcggacatcagt	12	11	3	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chr22:50588117G>A	uc003bjj.2	+	20	2784	c.2701G>A	c.(2701-2703)GGG>AGG	p.G901R	MOV10L1_uc003bjk.3_Missense_Mutation_p.G901R|MOV10L1_uc011arp.1_Missense_Mutation_p.G881R|MOV10L1_uc003bjl.2_Missense_Mutation_p.G28R|MOV10L1_uc003bjm.1_5'UTR	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	901					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CATTCCTCTGGGGCTGATGTC	0.562											OREG0026674	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	50588117	A	A	50588117	3	1	274	1	0	0	0	0	1	0	0	0	9719	1232	43	3	2832	3	MOV10L1	22	50588117	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08	6984538	50588117	716449	111	19751											
KDM6A	7403	broad.mit.edu	37	chrX	44929255	44929255	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctctctgccttgttgatGggaaaagccaataacaatgt	9	9	1	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chrX:44929255G>A	uc004dge.3	+	17	2730	c.2355G>A	c.(2353-2355)ATG>ATA	p.M785I	KDM6A_uc010nhk.2_Missense_Mutation_p.M751I|KDM6A_uc011mkz.1_Missense_Mutation_p.M837I|KDM6A_uc011mla.1_Missense_Mutation_p.M740I|KDM6A_uc011mlb.1_Missense_Mutation_p.M792I|KDM6A_uc011mlc.1_Missense_Mutation_p.M489I|KDM6A_uc011mld.1_Missense_Mutation_p.M424I	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	785					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						CCTTGTTGATGGGAAAAGCCA	0.448			D|N|F|S		renal|oesophageal SCC|MM								A	44929255	A	A	44929255	3	1	274	1	0	0	0	0	1	0	0	0	8137	1348	47	3	2421	3	KDM6A	23	44929255	Missense_Mutation	SNP	G	TCGA-76-6656-01A-11D-1845-08		44929255	110341305	112	19752											
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011554	105011554	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctactcaacggacagctacCccttaataacaccctgaaag	6	14	1	1			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chrX:105011554C>T	uc004elz.1	+	11	2717	c.1961C>T	c.(1960-1962)CCC>CTC	p.P654L		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	654	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						GGACAGCTACCCCTTAATAAC	0.448													T	105011554	T	T	105011554	3	4	274	1	0	0	0	0	1	0	0	0	7662	623	22	3	1999	3	IL1RAPL2	23	105011554	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	60082299	105011554	50259006	113	19753											
MAGEC2	51438	broad.mit.edu	37	chrX	141290669	141290669	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acttcactcagaaaaggagaCgttgctggacatgacactga	10	9	2	4			TCGA-76-6656-01A-11D-1845-08	TCGA-76-6656-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	fe66f11a-e03d-49c5-befe-db74ef55ce61	fb2cda88-4b45-4173-8340-49f54a899bc7	g.chrX:141290669C>T	uc004fbu.1	-	3	1453	c.1105G>A	c.(1105-1107)GTC>ATC	p.V369I		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	369						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GAAAAGGAGACGTTGCTGGAC	0.502										HNSCC(46;0.14)			T	141290669	T	T	141290669	3	4	274	1	0	0	0	0	1	0	0	0	9181	536	19	1	20	1	MAGEC2	23	141290669	Missense_Mutation	SNP	C	TCGA-76-6656-01A-11D-1845-08	36279115	141290669	13979891	114	19754											
CHD5	26038	broad.mit.edu	37	chr1	6209438	6209438	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcacacctcacagtaatcCtggtggtctgtctcatagcc	9	13	3	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:6209438C>T	uc001amb.1	-	8	1129	c.1029G>A	c.(1027-1029)CAG>CAA	p.Q343Q	CHD5_uc001amc.1_5'Flank	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	343	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CACAGTAATCCTGGTGGTCTG	0.577													T	6209438	T	T	6209438	2	4	275	1	0	0	0	0	0	0	0	1	3328	680	24	3		3	CHD5	1	6209438	Silent	SNP	C	TCGA-76-6657-01A-11D-1845-08		6209438	243041183	1	19755											
MACF1	23499	broad.mit.edu	37	chr1	39763324	39763324	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gcacgagagctggagtcattCttgaggaacctccaagattc	11	10	2	3			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:39763324C>G	uc010ois.1	+	22	2608	c.2403C>G	c.(2401-2403)TTC>TTG	p.F801L	MACF1_uc001cda.1_Missense_Mutation_p.F709L|MACF1_uc001cdc.1_5'Flank|MACF1_uc009vvq.1_5'Flank|MACF1_uc001cdb.1_5'Flank	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	801					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGGAGTCATTCTTGAGGAACC	0.443													G	39763324	G	G	39763324	3	3	275	1	0	0	0	0	1	0	0	0	9144	912	32	5	2481	5	MACF1	1	39763324	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	33553886	39763324	209487297	2	19756											
MPL	4352	broad.mit.edu	37	chr1	43812465	43812465	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgctgacatccctgtagtgCgcctccccaccccaaacttg	7	18	0	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:43812465C>T	uc001ciw.2	+	8	1213	c.1168C>T	c.(1168-1170)CGC>TGC	p.R390C	MPL_uc001civ.2_Missense_Mutation_p.R390C|MPL_uc009vwr.2_Missense_Mutation_p.R383C	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	390	Extracellular (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCCTGTAGTGCGCCTCCCCAC	0.582			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						T	43812465	T	T	43812465	3	4	275	1	0	0	0	0	1	0	0	0	9730	768	27	1	1198	1	MPL	1	43812465	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	4049141	43812465	205438156	3	19757											
EPS8L3	79574	broad.mit.edu	37	chr1	110293381	110293381	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtcttatgcgaagtagctgGctccccgtcagggacccaag	13	12	2	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:110293381G>A	uc001dyr.1	-	18	1816	c.1671C>T	c.(1669-1671)AGC>AGT	p.S557S	EPS8L3_uc001dys.1_Silent_p.S527S|EPS8L3_uc001dyq.1_Silent_p.S558S|EPS8L3_uc009wfm.1_Silent_p.S494S	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	557						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GAAGTAGCTGGCTCCCCGTCA	0.607													A	110293381	A	A	110293381	2	1	275	1	0	0	0	0	0	0	0	1	5197	1194	42	3		3	EPS8L3	1	110293381	Silent	SNP	G	TCGA-76-6657-01A-11D-1845-08	66480916	110293381	138957240	4	19758											
IGSF3	3321	broad.mit.edu	37	chr1	117150591	117150591	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaggactatgatggggatgtTcttgggacgcttgctctcct	14	8	2	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:117150591T>A	uc001egr.1	-	5	1900	c.1195A>T	c.(1195-1197)AAC>TAC	p.N399Y	IGSF3_uc001egq.1_Missense_Mutation_p.N399Y|IGSF3_uc001egs.1_Missense_Mutation_p.N72Y	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	399	Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		ATGGGGATGTTCTTGGGACGC	0.517													A	117150591	A	A	117150591	3	1	275	1	0	0	0	0	1	0	0	0	7601	1783	62	5	2481	5	IGSF3	1	117150591	Missense_Mutation	SNP	T	TCGA-76-6657-01A-11D-1845-08	6857210	117150591	132100030	5	19759											
LCE1F	353137	broad.mit.edu	37	chr1	152749094	152749094	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctgagccaccacagacggCgtaggtcccaccgccacaga	11	17	0	3			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:152749094C>T	uc010pdv.1	+	1	247	c.247C>T	c.(247-249)CGT>TGT	p.R83C		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	83	Poly-Arg.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCACAGACGGCGTAGGTCCCA	0.701													T	152749094	T	T	152749094	3	4	275	1	0	0	0	0	1	0	0	0	8664	768	27	1	249	1	LCE1F	1	152749094	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	35598503	152749094	96501527	6	19760											
OR10X1	128367	broad.mit.edu	37	chr1	158549258	158549258	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcagtggatatcttagaggGttacagatggccaggaagcg	15	6	1	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:158549258G>A	uc010pin.1	-	1	432	c.432C>T	c.(430-432)AAC>AAT	p.N144N		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	144	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					ATCTTAGAGGGTTACAGATGG	0.463													A	158549258	A	A	158549258	2	1	275	1	0	0	0	0	0	0	0	1	10922	1252	44	3		3	OR10X1	1	158549258	Silent	SNP	G	TCGA-76-6657-01A-11D-1845-08	5800164	158549258	90701363	7	19761											
TNFSF18	8995	broad.mit.edu	37	chr1	173010834	173010834	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggttcagaagatgccatttgCcattttgagggtaatggtcc	12	7	1	3			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:173010834C>T	uc001giu.2	-	3	274	c.273G>A	c.(271-273)TGG>TGA	p.W91*		NM_005092	NP_005083	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily,	91	Extracellular (Potential).				anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)	1						ATGCCATTTGCCATTTTGAGG	0.353													T	173010834	T	T	173010834	4	4	275	1	0	0	0	0	0	1	0	0	16306	740	26	3	330	3	TNFSF18	1	173010834	Nonsense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	14461576	173010834	76239787	8	19762											
RASAL2	9462	broad.mit.edu	37	chr1	178427055	178427055	+	Silent	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gtgcctatacgcttgaccggAagccagctttccataaccca	8	14	0	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:178427055A>T	uc001glr.2	+	12	2330	c.2205A>T	c.(2203-2205)GGA>GGT	p.G735G	RASAL2_uc001glq.2_Silent_p.G876G|RASAL2_uc009wxc.2_Silent_p.G249G	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	735					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						GCTTGACCGGAAGCCAGCTTT	0.572													T	178427055	T	T	178427055	2	4	275	1	0	0	0	0	0	0	0	1	13064	233	9	5		5	RASAL2	1	178427055	Silent	SNP	A	TCGA-76-6657-01A-11D-1845-08	5416221	178427055	70823566	9	19763											
OR2T3	343173	broad.mit.edu	37	chr1	248636975	248636975	+	Silent	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	tgtgggatccagatgttcttCtacctgaccctggctggagc	12	11	2	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr1:248636975C>T	uc001iel.1	+	1	324	c.324C>T	c.(322-324)TTC>TTT	p.F108F		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGATGTTCTTCTACCTGACCC	0.537													T	248636975	T	T	248636975	2	4	275	1	0	0	0	0	0	0	0	1	11023	912	32	3		3	OR2T3	1	248636975	Silent	SNP	C	TCGA-76-6657-01A-11D-1845-08	70209920	248636975	613646	10	19764											
MSH6	2956	broad.mit.edu	37	chr2	48023188	48023190	+	In_Frame_Del	DEL	GAA	-	-													agccctcagagccagaagagGaagaagagatggaggtggga							TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr2:48023188_48023190delGAA	uc002rwd.3	+	3	765_767	c.613_615delGAA	c.(613-615)GAAdel	p.E207del	MSH6_uc002rwc.2_In_Frame_Del_p.E207del|MSH6_uc010fbj.2_Intron|MSH6_uc010yoi.1_Intron|MSH6_uc010yoj.1_5'UTR	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	207	Poly-Glu.				determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GCCAGAAGAGGAAGAAGAGATGG	0.438			Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				-	48023190	-	-	48023188	7	5	275	1	0	1	0	1	0	0	0	0	9874	1175	41	0	623	0	MSH6	2	48023188	In_Frame_Del	DEL	GAA	TCGA-76-6657-01A-11D-1845-08		48023188	195176185	11	19765											
SCN3A	6328	broad.mit.edu	37	chr2	165952115	165952115	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgataaagatgacaaagtatAaatacatgtacagattttct	6	4	1	4			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr2:165952115A>G	uc002ucx.2	-	25	4829	c.4337T>C	c.(4336-4338)TTA>TCA	p.L1446S	SCN3A_uc010zcy.1_5'Flank|SCN3A_uc002ucy.2_Missense_Mutation_p.L1397S|SCN3A_uc002ucz.2_Missense_Mutation_p.L1397S	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1446	Helical; Name=S6 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GACAAAGTATAAATACATGTA	0.269													G	165952115	G	G	165952115	3	3	275	1	0	0	0	0	1	0	0	0	13918	372	13	4	1681	4	SCN3A	2	165952115	Missense_Mutation	SNP	A	TCGA-76-6657-01A-11D-1845-08	117928927	165952115	77247258	12	19766											
METTL5	29081	broad.mit.edu	37	chr2	170677785	170677785	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtcaaatccaacacacaaccTataaatacaaaacacataca	1	12	1	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr2:170677785T>C	uc002ufn.2	-	3	471	c.225_splice	c.e3-1	p.G75_splice	METTL5_uc002ufo.2_Splice_Site_p.G75_splice|METTL5_uc002ufp.2_Splice_Site_p.G75_splice|METTL5_uc002ufq.1_Splice_Site_p.G75_splice	NM_014168	NP_054887	Q9NRN9	METL5_HUMAN	methyltransferase like 5								methyltransferase activity|nucleic acid binding			central_nervous_system(1)	1						ACACACAACCTATAAATACAA	0.303													C	170677785	C	C	170677785	5	2	275	1	0	0	0	0	0	0	1	0	9503	1536	53	4	426	4	METTL5	2	170677785	Splice_Site	SNP	T	TCGA-76-6657-01A-11D-1845-08	4725670	170677785	72521588	13	19767											
CHRNG	1146	broad.mit.edu	37	chr2	233404776	233404776	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgaccccaacctgcggcccGcggaacgagactcggatgtg	13	15	0	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr2:233404776G>A	uc002vsx.1	+	2	151	c.130G>A	c.(130-132)GCG>ACG	p.A44T	CHRNG_uc010fyd.2_Missense_Mutation_p.A44T|CHRNG_uc010fye.1_Missense_Mutation_p.A44T	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	44	Extracellular (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CCTGCGGCCCGCGGAACGAGA	0.632													A	233404776	A	A	233404776	3	1	275	1	0	0	0	0	1	0	0	0	3396	1087	38	1	136	1	CHRNG	2	233404776	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	62726991	233404776	9794597	14	19768											
UGT2A1	10941	broad.mit.edu	37	chr4	70455172	70455172	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatgaccaaaaatatagccGttgtcacacagaccagcaag	8	10	1	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr4:70455172G>A	uc003hem.3	-	6	1565	c.1502C>T	c.(1501-1503)ACG>ATG	p.T501M	UGT2A1_uc011caq.1_Missense_Mutation_p.T667M|UGT2A1_uc010ihu.2_Missense_Mutation_p.T501M|UGT2A1_uc010iht.2_Missense_Mutation_p.T457M|UGT2A1_uc010ihs.2_Missense_Mutation_p.T502M	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	501	Helical; (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						AAATATAGCCGTTGTCACACA	0.413													A	70455172	A	A	70455172	3	1	275	1	0	0	0	0	1	0	0	0	16950	1145	40	1	85	1	UGT2A1	4	70455172	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08		70455172	120699104	15	19769											
FGA	2243	broad.mit.edu	37	chr4	155507683	155507683	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tccagtacttccaggtccagAgctcccagagttccagcttc	8	15	0	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr4:155507683A>T	uc003iod.1	-	5	956	c.898T>A	c.(898-900)TCT>ACT	p.S300T	FGA_uc003ioe.1_Missense_Mutation_p.S300T|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	300	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CCAGGTCCAGAGCTCCCAGAG	0.562													T	155507683	T	T	155507683	3	4	275	1	0	0	0	0	1	0	0	0	5830	304	11	5	1754	5	FGA	4	155507683	Missense_Mutation	SNP	A	TCGA-76-6657-01A-11D-1845-08	85052511	155507683	35646593	16	19770											
STOX2	56977	broad.mit.edu	37	chr4	184938294	184938294	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcattgttgaaagtaaccgtCgtcagaaccccgctttgagc	10	11	1	3			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr4:184938294C>T	uc003ivz.1	+	4	4073	c.2638C>T	c.(2638-2640)CGT>TGT	p.R880C	uc003iwb.1_5'Flank|STOX2_uc003iwa.1_3'UTR	NM_020225	NP_064610	Q9P2F5	STOX2_HUMAN	storkhead box 2	880					embryo development|maternal placenta development						0		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		AAGTAACCGTCGTCAGAACCC	0.502													T	184938294	T	T	184938294	3	4	275	1	0	0	0	0	1	0	0	0	15319	884	31	2	2652	2	STOX2	4	184938294	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	29430611	184938294	6215982	17	19771											
DNAH5	1767	broad.mit.edu	37	chr5	13885213	13885213	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaaatgagagagtaactcGcgggcttcttcccctaacat	9	10	1	3			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr5:13885213G>A	uc003jfd.2	-	19	2910	c.2868C>T	c.(2866-2868)CGC>CGT	p.R956R		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	956	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGAGTAACTCGCGGGCTTCTT	0.443									Kartagener_syndrome				A	13885213	A	A	13885213	2	1	275	1	0	0	0	0	0	0	0	1	4604	1074	38	1		1	DNAH5	5	13885213	Silent	SNP	G	TCGA-76-6657-01A-11D-1845-08		13885213	167030047	18	19772											
PIK3R1	5295	broad.mit.edu	37	chr5	67522740	67522741	+	Frame_Shift_Ins	INS	-	A	A													acgtagaatatattggaaggINSaaaaaaatctcgcctcccac							TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr5:67522740_67522741insA	uc003jva.2	+	2	797_798	c.237_238insA	c.(235-240)AGGAAAfs	p.R79fs	PIK3R1_uc003jvb.2_Frame_Shift_Ins_p.R79fs	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	79_80					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding			endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	ATATTGGAAGGAAAAAAATCTC	0.49			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			A	67522741	A	A	67522740	7	5	275	1	0	1	1	0	0	0	0	0	11918	1165	41	0	239	0	PIK3R1	5	67522740	Frame_Shift_Ins	INS	-	TCGA-76-6657-01A-11D-1845-08	53637527	67522740	113392520	19	19773											
GPR98	84059	broad.mit.edu	37	chr5	89992775	89992775	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaaaccaaaaagacagtcaTtttaaccatcttggatgact	6	8	2	3			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr5:89992775T>C	uc003kju.2	+	34	8063	c.7967T>C	c.(7966-7968)ATT>ACT	p.I2656T	GPR98_uc003kjt.2_Missense_Mutation_p.I362T|GPR98_uc003kjv.2_Missense_Mutation_p.I256T	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2656	Calx-beta 18.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGACAGTCATTTTAACCATC	0.368													C	89992775	C	C	89992775	3	2	275	1	0	0	0	0	1	0	0	0	6721	1493	52	4	8101	4	GPR98	5	89992775	Missense_Mutation	SNP	T	TCGA-76-6657-01A-11D-1845-08	22470035	89992775	90922485	20	19774											
ARAP3	64411	broad.mit.edu	37	chr5	141049346	141049346	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caaaatgctggatcctccccCcagcgaggatgagctcaaag	10	13	1	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr5:141049346C>T	uc003llm.2	-	16	2360	c.2282G>A	c.(2281-2283)GGG>GAG	p.G761E	ARAP3_uc011dbe.1_Missense_Mutation_p.G423E|ARAP3_uc003lln.2_Missense_Mutation_p.G663E	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	761					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						GATCCTCCCCCCAGCGAGGAT	0.587													T	141049346	T	T	141049346	3	4	275	1	0	0	0	0	1	0	0	0	840	623	22	3	2424	3	ARAP3	5	141049346	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	51056571	141049346	39865914	21	19775											
FAT2	2196	broad.mit.edu	37	chr5	150920247	150920247	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtacttggctgtatgctcgcGgtccagggtcttccttgagg	14	10	1	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr5:150920247G>A	uc003lue.3	-	10	8933	c.8920C>T	c.(8920-8922)CGC>TGC	p.R2974C	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2974	Extracellular (Potential).|Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTATGCTCGCGGTCCAGGGTC	0.527													A	150920247	A	A	150920247	3	1	275	1	0	0	0	0	1	0	0	0	5690	1116	39	2	4185	2	FAT2	5	150920247	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	9870901	150920247	29995013	22	19776											
C6orf221	154288	broad.mit.edu	37	chr6	74073351	74073351	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcggtcttcaatagaagtccGggaggccgggacgcagcgtt	16	10	2	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr6:74073351G>A	uc003pgt.3	+	3	475	c.422G>A	c.(421-423)CGG>CAG	p.R141Q		NM_001017361	NP_001017361	Q587J8	ECAT1_HUMAN	hypothetical protein LOC154288	141										skin(2)	2						ATAGAAGTCCGGGAGGCCGGG	0.657													A	74073351	A	A	74073351	3	1	275	1	0	0	0	0	1	0	0	0	2355	1116	39	2	432	2	C6orf221	6	74073351	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08		74073351	97041716	23	19777											
FYN	2534	broad.mit.edu	37	chr6	112015863	112015863	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtccacaagatttggtaattTcagagctcttccttctccat	6	11	3	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr6:112015863T>C	uc003pvj.2	-	10	1427	c.1087A>G	c.(1087-1089)AAA>GAA	p.K363E	FYN_uc003pvi.2_Missense_Mutation_p.K308E|FYN_uc003pvk.2_Missense_Mutation_p.K363E|FYN_uc003pvh.2_Missense_Mutation_p.K360E|FYN_uc010kdy.1_Missense_Mutation_p.K54E	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	363	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTTGGTAATTTCAGAGCTCTT	0.383													C	112015863	C	C	112015863	3	2	275	1	0	0	0	0	1	0	0	0	6126	1792	62	4	542	4	FYN	6	112015863	Missense_Mutation	SNP	T	TCGA-76-6657-01A-11D-1845-08	37942512	112015863	59099204	24	19778											
CNKSR3	154043	broad.mit.edu	37	chr6	154831213	154831213	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacctctagtccagtccacCacttgtttggggctccactt	8	15	1	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr6:154831213C>T	uc003qpy.2	-	1	541	c.36G>A	c.(34-36)GTG>GTA	p.V12V		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	12	SAM.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		TCCAGTCCACCACTTGTTTGG	0.652													T	154831213	T	T	154831213	2	4	275	1	0	0	0	0	0	0	0	1	3608	581	21	3		3	CNKSR3	6	154831213	Silent	SNP	C	TCGA-76-6657-01A-11D-1845-08	42815350	154831213	16283854	25	19779											
SUMF2	25870	broad.mit.edu	37	chr7	56144570	56144570	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggttccagccaaaccgcacCaacctgtggcaggtaagacc	10	14	0	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr7:56144570C>T	uc003trv.2	+	6	667	c.636C>T	c.(634-636)ACC>ACT	p.T212T	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Silent_p.T212T|SUMF2_uc011kcx.1_Intron|SUMF2_uc003trt.2_Silent_p.T105T|SUMF2_uc011kcy.1_Silent_p.T197T|SUMF2_uc011kcz.1_Intron|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_5'UTR|SUMF2_uc003trx.2_RNA	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	193						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CAAACCGCACCAACCTGTGGC	0.418													T	56144570	T	T	56144570	2	4	275	1	0	0	0	0	0	0	0	1	15383	581	21	3		3	SUMF2	7	56144570	Silent	SNP	C	TCGA-76-6657-01A-11D-1845-08		56144570	102994093	26	19780											
CACNA2D1	781	broad.mit.edu	37	chr7	81611940	81611940	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tatctggcttcagggtttccGaatctgcaaagataatgtta	9	7	3	1	rs149510838		TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr7:81611940G>A	uc003uhr.1	-	24	2154	c.1898C>T	c.(1897-1899)TCG>TTG	p.S633L		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	645	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CAGGGTTTCCGAATCTGCAAA	0.333													A	81611940	A	A	81611940	3	1	275	1	0	0	0	0	1	0	0	0	2548	1059	37	2	1441	2	CACNA2D1	7	81611940	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	25467370	81611940	77526723	27	19781											
UBR5	51366	broad.mit.edu	37	chr8	103340098	103340099	+	Frame_Shift_Ins	INS	-	A	A													atttagaagccacagaacttINSaaagtttcatccacccatgt							TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr8:103340098_103340099insA	uc003ykr.1	-	12	1385_1386	c.1352_1353insT	c.(1351-1353)TTAfs	p.L451fs	UBR5_uc003yks.1_Frame_Shift_Ins_p.L451fs	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	451					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CCACAGAACTTAAAGTTTCATC	0.376													A	103340099	A	A	103340098	7	5	275	1	0	1	1	0	0	0	0	0	16902	1751	61	0	7238	0	UBR5	8	103340098	Frame_Shift_Ins	INS	-	TCGA-76-6657-01A-11D-1845-08		103340098	43023924	28	19782											
CTHRC1	115908	broad.mit.edu	37	chr8	104388028	104388028	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgagacgggagccctggggcCaatggcattccgggtacacc	15	13	0	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr8:104388028C>T	uc003ylk.2	+	2	312	c.213C>T	c.(211-213)GCC>GCT	p.A71A	CTHRC1_uc011lhq.1_Silent_p.A71A	NM_138455	NP_612464	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	71	Collagen-like.					collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			GCCCTGGGGCCAATGGCATTC	0.522													T	104388028	T	T	104388028	2	4	275	1	0	0	0	0	0	0	0	1	4010	581	21	3		3	CTHRC1	8	104388028	Silent	SNP	C	TCGA-76-6657-01A-11D-1845-08	1047930	104388028	41975994	29	19783											
EPPK1	83481	broad.mit.edu	37	chr8	144940918	144940918	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggaaccacaggtgtttgttGctggtttcctgcttctcgat	11	9	1	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr8:144940918G>T	uc003zaa.1	-	1	6517	c.6504C>A	c.(6502-6504)AGC>AGA	p.S2168R		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2168						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTGTTTGTTGCTGGTTTCCT	0.507													T	144940918	T	T	144940918	3	4	275	1	0	0	0	0	1	0	0	0	5190	1310	46	5	762	5	EPPK1	8	144940918	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	40552890	144940918	1423104	30	19784											
PTEN	5728	broad.mit.edu	37	chr10	89692852	89692856	+	Frame_Shift_Del	DEL	AAGTG	-	-													gaagatcttgaccaatggctAagtgaagatgacaatcatgt							TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr10:89692852_89692856delAAGTG	uc001kfb.2	+	6	1367_1371	c.336_340delAAGTG	c.(334-342)CTAAGTGAAfs	p.L112fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	112_114	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.L112V(4)|p.R55fs*1(4)|p.?(2)|p.L112P(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.L112fs*3(1)|p.L112R(1)|p.E114*(1)|p.S113fs*9(1)|p.S113R(1)|p.S113fs*20(1)|p.F56fs*2(1)|p.L112Q(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ACCAATGGCTAAGTGAAGATGACAA	0.376		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			-	89692856	-	-	89692852	7	5	275	1	0	1	0	1	0	0	0	0	12738	349	13	0	354	0	PTEN	10	89692852	Frame_Shift_Del	DEL	AAGTG	TCGA-76-6657-01A-11D-1845-08		89692852	45841895	31	19785											
CYP2C8	1558	broad.mit.edu	37	chr10	96827103	96827103	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttccatctctttccattgcTggaaatgattcctaataaaa	4	10	1	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr10:96827103T>G	uc001kkb.2	-	3	438	c.343A>C	c.(343-345)AGC>CGC	p.S115R	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.S45R|CYP2C8_uc010qob.1_Missense_Mutation_p.S29R|CYP2C8_uc010qoc.1_Missense_Mutation_p.S13R|CYP2C8_uc010qod.1_Missense_Mutation_p.S29R	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	115					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TTTCCATTGCTGGAAATGATT	0.483													G	96827103	G	G	96827103	3	3	275	1	0	0	0	0	1	0	0	0	4167	1580	55	5	1157	5	CYP2C8	10	96827103	Missense_Mutation	SNP	T	TCGA-76-6657-01A-11D-1845-08	7134251	96827103	38707644	32	19786											
DUSP5	1847	broad.mit.edu	37	chr10	112269798	112269798	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actgtgtcagggaaaagggaGgcaaggtcctggtccactgt	15	8	1	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr10:112269798G>A	uc001kzd.2	+	4	1024	c.769G>A	c.(769-771)GGC>AGC	p.G257S		NM_004419	NP_004410	Q16690	DUS5_HUMAN	dual specificity phosphatase 5	257	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1		Breast(234;0.0848)		Epithelial(162;0.000276)|all cancers(201;0.00465)|BRCA - Breast invasive adenocarcinoma(275;0.12)		GGAAAAGGGAGGCAAGGTCCT	0.512													A	112269798	A	A	112269798	3	1	275	1	0	0	0	0	1	0	0	0	4828	1000	35	3	783	3	DUSP5	10	112269798	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	15442695	112269798	23264949	33	19787											
HABP2	3026	broad.mit.edu	37	chr10	115341658	115341658	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ttgcctacccagaggaaagcCccactgagccatcaaccaag	8	15	1	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr10:115341658C>A	uc001lai.3	+	9	965	c.862C>A	c.(862-864)CCC>ACC	p.P288T	HABP2_uc010qrz.1_Intron	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	288					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		AGAGGAAAGCCCCACTGAGCC	0.507													A	115341658	A	A	115341658	3	1	275	1	0	0	0	0	1	0	0	0	6938	623	22	5	896	5	HABP2	10	115341658	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	3071860	115341658	20193089	34	19788											
OR5B3	441608	broad.mit.edu	37	chr11	58170350	58170350	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gaaccatgactgctggaataTcacagaaaaagtgatggact	10	7	1	3			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr11:58170350T>A	uc010rkf.1	-	1	533	c.533A>T	c.(532-534)GAT>GTT	p.D178V		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGCTGGAATATCACAGAAAAA	0.423													A	58170350	A	A	58170350	3	1	275	1	0	0	0	0	1	0	0	0	11152	1435	50	5	413	5	OR5B3	11	58170350	Missense_Mutation	SNP	T	TCGA-76-6657-01A-11D-1845-08		58170350	76836166	35	19789											
CASP1	834	broad.mit.edu	37	chr11	104899923	104899923	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	aatagcatcatcctcaaactCttctgtagttggtaaagata	6	8	4	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr11:104899923C>A	uc010rve.1	-	7	951	c.934G>T	c.(934-936)GAG>TAG	p.E312*	CASP1_uc001pig.2_Nonsense_Mutation_p.E219*|CASP1_uc001pik.2_Nonsense_Mutation_p.E275*|CASP1_uc010rvf.1_Nonsense_Mutation_p.E219*|CASP1_uc010rvg.1_Nonsense_Mutation_p.E291*|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CASP1_uc001pim.3_Nonsense_Mutation_p.E312*|CASP1_uc009yxi.2_Nonsense_Mutation_p.E291*|CASP1_uc010rvj.1_Nonsense_Mutation_p.E312*|CASP1_uc009yxj.2_Nonsense_Mutation_p.E157*|CASP1_uc010rvk.1_Nonsense_Mutation_p.E273*	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	312					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TCCTCAAACTCTTCTGTAGTT	0.408													A	104899923	A	A	104899923	4	1	275	1	0	0	0	0	0	1	0	0	2668	922	32	5	292	5	CASP1	11	104899923	Nonsense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	46729573	104899923	30106593	36	19790											
OR8D1	283159	broad.mit.edu	37	chr11	124179842	124179842	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ccgtggtgtagaacacagagGacaccttctcctggtccagg	12	12	1	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr11:124179842G>A	uc010sag.1	-	1	821	c.821C>T	c.(820-822)TCC>TTC	p.S274F		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GAACACAGAGGACACCTTCTC	0.463													A	124179842	A	A	124179842	3	1	275	1	0	0	0	0	1	0	0	0	11231	1174	41	3	108	3	OR8D1	11	124179842	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	19279919	124179842	10826674	37	19791											
OR8B4	283162	broad.mit.edu	37	chr11	124294437	124294439	+	In_Frame_Del	DEL	ACT	-	-													cattgataccaacacatagcActcagaattgacaaagaaac							TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr11:124294437_124294439delACT	uc010sak.1	-	1	329_331	c.329_331delAGT	c.(328-333)GAGTGC>GGC	p.110_111EC>G		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	110_111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AACACATAGCACTCAGAATTGAC	0.433													-	124294439	-	-	124294437	7	5	275	1	0	1	0	1	0	0	0	0	11229	159	6	0	600	0	OR8B4	11	124294437	In_Frame_Del	DEL	ACT	TCGA-76-6657-01A-11D-1845-08	114595	124294437	10712079	38	19792											
DYRK4	8798	broad.mit.edu	37	chr12	4708241	4708241	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taacaactttcaaggcttcaGtctgtccatagttcggcgct	8	11	3	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr12:4708241G>A	uc001qmx.2	+	7	768	c.608G>A	c.(607-609)AGT>AAT	p.S203N	DYRK4_uc009zeh.1_Missense_Mutation_p.S318N|DYRK4_uc001qmy.1_Missense_Mutation_p.S203N	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	203	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			CAAGGCTTCAGTCTGTCCATA	0.413													A	4708241	A	A	4708241	3	1	275	1	0	0	0	0	1	0	0	0	4858	1029	36	3	626	3	DYRK4	12	4708241	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08		4708241	129143654	39	19793											
PIK3C2G	5288	broad.mit.edu	37	chr12	18658296	18658296	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catcctgggagtatgtgaccGtcacaatgataatatcatgc	9	9	2	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr12:18658296G>A	uc001rdt.2	+	23	3217	c.3101G>A	c.(3100-3102)CGT>CAT	p.R1034H	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.R1075H|PIK3C2G_uc010sic.1_Missense_Mutation_p.R853H	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1034	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GTATGTGACCGTCACAATGAT	0.398													A	18658296	A	A	18658296	3	1	275	1	0	0	0	0	1	0	0	0	11911	1145	40	1	3187	1	PIK3C2G	12	18658296	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	13950055	18658296	115193599	40	19794											
ALX1	8092	broad.mit.edu	37	chr12	85695206	85695206	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cttccagtatcgcagttcttCgaatgaaagccaaggagcac	9	11	1	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr12:85695206C>T	uc001tae.3	+	4	938	c.934C>T	c.(934-936)CGA>TGA	p.R312*		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	312	OAR.				brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		CGCAGTTCTTCGAATGAAAGC	0.378													T	85695206	T	T	85695206	4	4	275	1	0	0	0	0	0	1	0	0	556	876	31	2	948	2	ALX1	12	85695206	Nonsense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	67036910	85695206	48156689	41	19795											
ACACB	32	broad.mit.edu	37	chr12	109687832	109687832	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaaggatgatggcttgggcGtggagaatctgaggggctca	19	5	2	3			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr12:109687832G>A	uc001tob.2	+	41	5832	c.5713G>A	c.(5713-5715)GTG>ATG	p.V1905M	ACACB_uc001toc.2_Missense_Mutation_p.V1905M|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.V571M	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1905	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TGGCTTGGGCGTGGAGAATCT	0.493													A	109687832	A	A	109687832	3	1	275	1	0	0	0	0	1	0	0	0	107	1145	40	1	5871	1	ACACB	12	109687832	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	23992626	109687832	24164063	42	19796											
GCN1L1	10985	broad.mit.edu	37	chr12	120582480	120582480	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgatgggccccacataaggaGtaaacttgtctccaaaggtg	11	9	1	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr12:120582480G>A	uc001txo.2	-	41	5328	c.5315C>T	c.(5314-5316)ACT>ATT	p.T1772I		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1772					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CACATAAGGAGTAAACTTGTC	0.512													A	120582480	A	A	120582480	3	1	275	1	0	0	0	0	1	0	0	0	6299	1029	36	3	2772	3	GCN1L1	12	120582480	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	10894648	120582480	13269415	43	19797											
ZC3H13	23091	broad.mit.edu	37	chr13	46549530	46549530	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcttcccaatccctttggcGttctcgttctttatcccttt	5	14	3	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr13:46549530G>A	uc010tfw.1	-	11	2362	c.2356C>T	c.(2356-2358)CGC>TGC	p.R786C	ZC3H13_uc001vas.1_Missense_Mutation_p.R786C|ZC3H13_uc001vat.1_Missense_Mutation_p.R786C	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	786	Arg/Glu-rich.|Potential.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCCCTTTGGCGTTCTCGTTCT	0.259													A	46549530	A	A	46549530	3	1	275	1	0	0	0	0	1	0	0	0	17562	1145	40	1	2362	1	ZC3H13	13	46549530	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08		46549530	68620348	44	19798											
PCID2	55795	broad.mit.edu	37	chr13	113834511	113834511	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccgcaaactgcatcaggtgaTactttttcaggagctccaca	8	12	2	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr13:113834511T>A	uc010tju.1	-	11	902	c.821A>T	c.(820-822)TAT>TTT	p.Y274F	PCID2_uc001vtb.2_Missense_Mutation_p.Y107F|PCID2_uc010tjv.1_Missense_Mutation_p.Y274F|PCID2_uc010tjw.1_Missense_Mutation_p.Y274F|PCID2_uc001vte.2_Missense_Mutation_p.Y167F|PCID2_uc001vtd.2_Missense_Mutation_p.Y167F|PCID2_uc001vtf.2_Missense_Mutation_p.Y167F	NM_001127203	NP_001120675	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	274					negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			CATCAGGTGATACTTTTTCAG	0.413													A	113834511	A	A	113834511	3	1	275	1	0	0	0	0	1	0	0	0	11579	1406	49	5	394	5	PCID2	13	113834511	Missense_Mutation	SNP	T	TCGA-76-6657-01A-11D-1845-08	67284981	113834511	1335367	45	19799											
OR4E2	26686	broad.mit.edu	37	chr14	22134222	22134222	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagagacaagtttttttcaCgaaatcatatacataatggg	8	6	2	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr14:22134222C>T	uc010tmd.1	+	1	926	c.926C>T	c.(925-927)ACG>ATG	p.T309M		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		GTTTTTTTCACGAAATCATAT	0.393													T	22134222	T	T	22134222	3	4	275	1	0	0	0	0	1	0	0	0	11060	536	19	1	928	1	OR4E2	14	22134222	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08		22134222	85215318	46	19800											
JAG2	3714	broad.mit.edu	37	chr14	105622280	105622280	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggctcttccagcggtcctcCgggttgatcatgccggcatg	13	13	2	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr14:105622280C>T	uc001yqg.2	-	4	926	c.522G>A	c.(520-522)CCG>CCA	p.P174P	JAG2_uc001yqh.2_Silent_p.P174P	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	174	Extracellular (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		AGCGGTCCTCCGGGTTGATCA	0.652													T	105622280	T	T	105622280	2	4	275	1	0	0	0	0	0	0	0	1	7935	639	23	2		2	JAG2	14	105622280	Silent	SNP	C	TCGA-76-6657-01A-11D-1845-08	83488058	105622280	1727260	47	19801											
UNC13C	440279	broad.mit.edu	37	chr15	54786821	54786821	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tatagaacatgaaaatcagcGgttatgcaagagcaccgatt	9	7	1	3			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr15:54786821G>A	uc002ack.2	+	18	4949	c.4949G>A	c.(4948-4950)CGG>CAG	p.R1650Q		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1650	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GAAAATCAGCGGTTATGCAAG	0.308													A	54786821	A	A	54786821	3	1	275	1	0	0	0	0	1	0	0	0	16983	1116	39	2	5019	2	UNC13C	15	54786821	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08		54786821	47744571	48	19802											
CSK	1445	broad.mit.edu	37	chr15	75092831	75092831	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agggcacagtggcggcccagGatgagttctaccgcagtgag	16	10	1	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr15:75092831G>A	uc010bkb.1	+	7	724	c.541G>A	c.(541-543)GAT>AAT	p.D181N	CSK_uc002ays.2_Missense_Mutation_p.D181N|CSK_uc010bkc.1_5'UTR	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	181					blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						GGCGGCCCAGGATGAGTTCTA	0.632											OREG0023291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	75092831	A	A	75092831	3	1	275	1	0	0	0	0	1	0	0	0	3943	1174	41	3	559	3	CSK	15	75092831	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	20306010	75092831	27438561	49	19803											
ADAMTS7	11173	broad.mit.edu	37	chr15	79057006	79057006	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	catcccggccggagctacagCgcaccggcctccagaccgca	11	19	0	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr15:79057006C>T	uc002bej.3	-	20	4521	c.4310G>A	c.(4309-4311)CGC>CAC	p.R1437H		NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1437	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						GGAGCTACAGCGCACCGGCCT	0.726													T	79057006	T	T	79057006	3	4	275	1	0	0	0	0	1	0	0	0	271	768	27	1	770	1	ADAMTS7	15	79057006	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	3964175	79057006	23474386	50	19804											
ALPK3	57538	broad.mit.edu	37	chr15	85383056	85383056	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aagatccaccagcgctggttCgccaagttgaagcgcaaggc	12	12	0	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr15:85383056C>T	uc002ble.2	+	5	1319	c.1152C>T	c.(1150-1152)TTC>TTT	p.F384F		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	384					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCGCTGGTTCGCCAAGTTGA	0.617													T	85383056	T	T	85383056	2	4	275	1	0	0	0	0	0	0	0	1	546	883	31	2		2	ALPK3	15	85383056	Silent	SNP	C	TCGA-76-6657-01A-11D-1845-08	6326050	85383056	17148336	51	19805											
BLM	641	broad.mit.edu	37	chr15	91341566	91341566	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgctggtcgacattttcttGggtaagtcatctgttttgaa	10	6	3	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr15:91341566G>A	uc002bpr.2	+	17	3454	c.3357G>A	c.(3355-3357)TTG>TTA	p.L1119L	BLM_uc010uqh.1_Silent_p.L1119L|BLM_uc010uqi.1_Silent_p.L744L|BLM_uc010bnx.2_Silent_p.L1119L|BLM_uc002bpt.2_Silent_p.L94L	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1119					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			ACATTTTCTTGGGTAAGTCAT	0.294			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				A	91341566	A	A	91341566	2	1	275	1	0	0	0	0	0	0	0	1	1445	1362	47	3		3	BLM	15	91341566	Silent	SNP	G	TCGA-76-6657-01A-11D-1845-08	5958510	91341566	11189826	52	19806											
MEF2A	4205	broad.mit.edu	37	chr15	100230604	100230604	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	atcttcgagttgtcatccccCcttcaagcaagggcatgatg	9	12	3	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr15:100230604C>G	uc010urw.1	+	7	1194	c.835C>G	c.(835-837)CCT>GCT	p.P279A	MEF2A_uc010urv.1_Missense_Mutation_p.P209A|MEF2A_uc010bos.2_Missense_Mutation_p.P277A|MEF2A_uc002bvf.2_Missense_Mutation_p.P279A|MEF2A_uc002bve.2_Missense_Mutation_p.P277A|MEF2A_uc002bvg.2_Missense_Mutation_p.P277A|MEF2A_uc002bvi.2_Missense_Mutation_p.P277A|MEF2A_uc010bot.2_Missense_Mutation_p.P209A	NM_005587	NP_005578	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A isoform 1	279	Required for interaction with MAPKs.		P -> L.		apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			ovary(1)	1	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			TGTCATCCCCCCTTCAAGCAA	0.428													G	100230604	G	G	100230604	3	3	275	1	0	0	0	0	1	0	0	0	9455	623	22	5	993	5	MEF2A	15	100230604	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	8889038	100230604	2300788	53	19807											
ACSM2A	123876	broad.mit.edu	37	chr16	20494409	20494409	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcatttgtggtcctggcctcGcagttcctgtcccatgaccc	10	15	0	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr16:20494409G>A	uc010bwe.2	+	14	1778	c.1539G>A	c.(1537-1539)TCG>TCA	p.S513S	ACSM2A_uc002dhf.3_Silent_p.S513S|ACSM2A_uc002dhg.3_Silent_p.S513S|ACSM2A_uc010vay.1_Silent_p.S434S|ACSM2A_uc002dhh.3_Silent_p.S143S	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	513					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						TCCTGGCCTCGCAGTTCCTGT	0.498													A	20494409	A	A	20494409	2	1	275	1	0	0	0	0	0	0	0	1	183	1074	38	1		1	ACSM2A	16	20494409	Silent	SNP	G	TCGA-76-6657-01A-11D-1845-08		20494409	69860344	54	19808											
CDH5	1003	broad.mit.edu	37	chr16	66432371	66432371	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cactccagctggtcctgcagAtctccgcaatagacaaggac	9	14	1	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr16:66432371A>C	uc002eom.3	+	10	1654	c.1498A>C	c.(1498-1500)ATC>CTC	p.I500L		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	500	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GGTCCTGCAGATCTCCGCAAT	0.493													C	66432371	C	C	66432371	3	2	275	1	0	0	0	0	1	0	0	0	3113	333	12	5	1532	5	CDH5	16	66432371	Missense_Mutation	SNP	A	TCGA-76-6657-01A-11D-1845-08	45937962	66432371	23922382	55	19809											
NF1	4763	broad.mit.edu	37	chr17	29556484	29556484	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttttgactcccaaggacagGtaaagtgttctcttattttt	7	7	1	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr17:29556484G>A	uc002hgg.2	+	21	3183	c.2850_splice	c.e21+1	p.Q950_splice	NF1_uc002hgh.2_Splice_Site_p.Q950_splice|NF1_uc010csn.1_Splice_Site_p.Q810_splice|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CCAAGGACAGGTAAAGTGTTC	0.343			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			A	29556484	A	A	29556484	5	1	275	1	0	0	0	0	0	0	1	0	10356	1275	44	3	2994	3	NF1	17	29556484	Splice_Site	SNP	G	TCGA-76-6657-01A-11D-1845-08		29556484	51638726	56	19810											
NF1	4763	broad.mit.edu	37	chr17	29683590	29683590	+	Frame_Shift_Del	DEL	T	-	-													aggagagtagcagaaactgaTtatgaaatgggtgagaaaca							TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr17:29683590delT	uc002hgg.2	+	52	8061	c.7728delT	c.(7726-7728)GATfs	p.D2576fs	NF1_uc002hgh.2_Frame_Shift_Del_p.D2555fs|NF1_uc010cso.2_Frame_Shift_Del_p.D764fs|NF1_uc010wbt.1_Frame_Shift_Del_p.D54fs|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2576					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CAGAAACTGATTATGAAATGG	0.378			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			-	29683590	-	-	29683590	7	5	275	1	0	1	0	1	0	0	0	0	10356	1490	52	0	7995	0	NF1	17	29683590	Frame_Shift_Del	DEL	T	TCGA-76-6657-01A-11D-1845-08	127106	29683590	51511620	57	19811											
RAB11FIP4	84440	broad.mit.edu	37	chr17	29850996	29850997	+	Frame_Shift_Del	DEL	AC	-	-													gagcaagctgaagcaagagaAcacacagctggtgcacaggt							TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr17:29850996_29850997delAC	uc002hgn.1	+	9	1344_1345	c.1115_1116delAC	c.(1114-1116)AACfs	p.N372fs	RAB11FIP4_uc002hgo.2_Frame_Shift_Del_p.N270fs	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	372	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				AAGCAAGAGAACACACAGCTGG	0.599													-	29850997	-	-	29850996	7	5	275	1	0	1	0	1	0	0	0	0	12896	43	2	0	1149	0	RAB11FIP4	17	29850996	Frame_Shift_Del	DEL	AC	TCGA-76-6657-01A-11D-1845-08	167406	29850996	51344214	58	19812											
ANKRD30B	374860	broad.mit.edu	37	chr18	14779969	14779969	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	1	0	1	1	0	0	0	0	acatttttagatcagatgttCccatcagaatccaaacgaga	6	9	2	4	rs9675365	by1000genomes	TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr18:14779969C>G	uc010dlo.2	+	11	1611	c.1431C>G	c.(1429-1431)TTC>TTG	p.F477L	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	477										ovary(1)|skin(1)	2						ATCAGATGTTCCCATCAGAAT	0.279													G	14779969	G	G	14779969	3	3	275	1	0	0	0	0	1	0	0	0	659	854	30	5	1473	5	ANKRD30B	18	14779969	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08		14779969	63297279	59	19813											
C19orf21	126353	broad.mit.edu	37	chr19	757476	757476	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caggacccccggcccacctcGgtccacgcccctggaggaga	12	19	0	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr19:757476G>A	uc002lpo.2	+	2	613	c.530G>A	c.(529-531)CGG>CAG	p.R177Q		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	177										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCCACCTCGGTCCACGCCC	0.667													A	757476	A	A	757476	3	1	275	1	0	0	0	0	1	0	0	0	1913	1116	39	2	532	2	C19orf21	19	757476	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08		757476	58371507	60	19814											
REXO1	57455	broad.mit.edu	37	chr19	1827011	1827011	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gtagtccacatccgcccccgCgctggaggtggaggaggagg	17	12	0	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr19:1827011C>G	uc002lua.3	-	2	1872	c.1777G>C	c.(1777-1779)GCG>CCG	p.A593P	REXO1_uc010dsr.1_Missense_Mutation_p.A547P	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	593						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGCCCCCGCGCTggaggtg	0.473													G	1827011	G	G	1827011	3	3	275	1	0	0	0	0	1	0	0	0	13241	768	27	5	1948	5	REXO1	19	1827011	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	1069535	1827011	57301972	61	19815											
FCER2	2208	broad.mit.edu	37	chr19	7763247	7763247	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaccccttcataccgttcCgggcagccctctcttccagc	7	18	2	1			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr19:7763247C>T	uc002mhn.2	-	4	369	c.185G>A	c.(184-186)CGG>CAG	p.R62Q	FCER2_uc010xjs.1_5'UTR|FCER2_uc010xjt.1_5'UTR|FCER2_uc002mhm.2_Missense_Mutation_p.R62Q|FCER2_uc010dvo.2_Missense_Mutation_p.R62Q	NM_002002	NP_001993	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor	62	Extracellular (Potential).				positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding				0						CATACCGTTCCGGGCAGCCCT	0.622													T	7763247	T	T	7763247	3	4	275	1	0	0	0	0	1	0	0	0	5776	652	23	2	812	2	FCER2	19	7763247	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	5936236	7763247	51365736	62	19816											
FBN3	84467	broad.mit.edu	37	chr19	8183822	8183822	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccgtcagctcatgcccagggGgacactggcacttgtagctc	12	14	2	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr19:8183822G>A	uc002mjf.2	-	25	3317	c.3296C>T	c.(3295-3297)CCC>CTC	p.P1099L		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1099	EGF-like 14; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						ATGCCCAGGGGGACACTGGCA	0.592													A	8183822	A	A	8183822	3	1	275	1	0	0	0	0	1	0	0	0	5704	1232	43	3	5289	3	FBN3	19	8183822	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	420575	8183822	50945161	63	19817											
SALL4	57167	broad.mit.edu	37	chr20	50407510	50407510	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggcccaggctgcaggtcaccGggcaaggagccacccgtgag	16	14	1	1	rs138804604	byFrequency	TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr20:50407510G>A	uc002xwh.3	-	2	1613	c.1512C>T	c.(1510-1512)CCC>CCT	p.P504P	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	504					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GCAGGTCACCGGGCAAGGAGC	0.567													A	50407510	A	A	50407510	2	1	275	1	0	0	0	0	0	0	0	1	13813	1103	39	2		2	SALL4	20	50407510	Silent	SNP	G	TCGA-76-6657-01A-11D-1845-08		50407510	12618010	64	19818											
LAMA5	3911	broad.mit.edu	37	chr20	60928193	60928193	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	cggcggcagagactcacaggCaaagaactgccagggctggt	15	11	1	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr20:60928193C>G	uc002ycq.2	-	3	632	c.565G>C	c.(565-567)GCC>CCC	p.A189P		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	189	Laminin N-terminal.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GACTCACAGGCAAAGAACTGC	0.662													G	60928193	G	G	60928193	3	3	275	1	0	0	0	0	1	0	0	0	8609	710	25	5	10834	5	LAMA5	20	60928193	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08	10520683	60928193	2097327	65	19819											
KRTAP10-12	386685	broad.mit.edu	37	chr21	46117243	46117243	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctgtgagcccccctgctgcGccccggccccctgcctgagc	12	21	0	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr21:46117243G>A	uc002zfw.1	+	1	157	c.127G>A	c.(127-129)GCC>ACC	p.A43T	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198699	NP_941972	P60413	KR10C_HUMAN	keratin associated protein 10-12	43	2.|19 X 5 AA repeats of C-C-X(3).					keratin filament					0						CCCCTGCTGCGCCCCGGCCCC	0.677													A	46117243	A	A	46117243	3	1	275	1	0	0	0	0	1	0	0	0	8508	1087	38	1	129	1	KRTAP10-12	21	46117243	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08		46117243	2012652	66	19820											
POTEH	23784	broad.mit.edu	37	chr22	16287770	16287770	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtgcccacgttgctcttgCcgctccccctgcaccaggcg	10	18	1	0			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr22:16287770C>T	uc010gqp.2	-	1	168	c.116G>A	c.(115-117)GGC>GAC	p.G39D	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	39										skin(1)	1						GTTGCTCTTGCCGCTCCCCCT	0.592													T	16287770	T	T	16287770	3	4	275	1	0	0	0	0	1	0	0	0	12267	739	26	3	1561	3	POTEH	22	16287770	Missense_Mutation	SNP	C	TCGA-76-6657-01A-11D-1845-08		16287770	35016796	67	19821											
LZTR1	8216	broad.mit.edu	37	chr22	21342326	21342326	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cactggggacatttattccaAttctaacttgaagaataaaa	6	7	1	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr22:21342326A>C	uc002zto.2	+	5	531	c.428A>C	c.(427-429)AAT>ACT	p.N143T	LZTR1_uc002ztn.2_Missense_Mutation_p.N102T|LZTR1_uc011ahy.1_Missense_Mutation_p.N124T|LZTR1_uc010gsr.1_Missense_Mutation_p.N14T	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	143	Kelch 2.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			ATTTATTCCAATTCTAACTTG	0.438													C	21342326	C	C	21342326	3	2	275	1	0	0	0	0	1	0	0	0	9137	101	4	5	446	5	LZTR1	22	21342326	Missense_Mutation	SNP	A	TCGA-76-6657-01A-11D-1845-08	5054556	21342326	29962240	68	19822											
C1QTNF6	114904	broad.mit.edu	37	chr22	37581479	37581479	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cccagacgggacccagggcgGctgtccccatggtgacctgg	15	15	0	2			TCGA-76-6657-01A-11D-1845-08	TCGA-76-6657-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6ba47878-126c-420d-b3c1-ca7ea8c182d0	5d0ee6bc-8f13-4dd5-a7c0-7145c3fb0b7e	g.chr22:37581479G>T	uc003aqw.1	-	1	516	c.11C>A	c.(10-12)GCC>GAC	p.A4D	C1QTNF6_uc003aqx.1_Missense_Mutation_p.A23D|C1QTNF6_uc003aqy.1_Missense_Mutation_p.A23D|C1QTNF6_uc003aqz.1_RNA	NM_182486	NP_872292	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6	4						collagen					0						ACCCAGGGCGGCTGTCCCCAT	0.433													T	37581479	T	T	37581479	3	4	275	1	0	0	0	0	1	0	0	0	1967	1203	42	5	776	5	C1QTNF6	22	37581479	Missense_Mutation	SNP	G	TCGA-76-6657-01A-11D-1845-08	16239153	37581479	13723087	69	19823											
C1orf86	199990	broad.mit.edu	37	chr1	2125232	2125232	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttccaggtgccctcctgcccCgtgaagcagccggtaggaac	12	15	0	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr1:2125232C>T	uc001aiy.2	-	3	342	c.316G>A	c.(316-318)GGG>AGG	p.G106R	C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA|C1orf86_uc001aix.1_Silent_p.T101T	NM_182533	NP_872339	Q6NZ36	CA086_HUMAN	hypothetical protein LOC199990 isoform 2	106											0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CCTCCTGCCCCGTGAAGCAGC	0.692													T	2125232	T	T	2125232	3	4	276	1	0	0	0	0	1	0	0	0	2063	652	23	2	474	2	C1orf86	1	2125232	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08		2125232	247125389	1	19824											
SPEN	23013	broad.mit.edu	37	chr1	16260992	16260992	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttactgctgcatctggtggtGtaacggccacaacaggcacg	12	11	1	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr1:16260992G>A	uc001axk.1	+	11	8461	c.8257G>A	c.(8257-8259)GTA>ATA	p.V2753I	SPEN_uc010obp.1_Missense_Mutation_p.V2712I	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2753	Interaction with RBPSUH (By similarity).				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ATCTGGTGGTGTAACGGCCAC	0.577													A	16260992	A	A	16260992	3	1	276	1	0	0	0	0	1	0	0	0	15037	1377	48	3	8299	3	SPEN	1	16260992	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	14135760	16260992	232989629	2	19825											
OPRD1	4985	broad.mit.edu	37	chr1	29189500	29189500	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgccttcgtggtgtgttgggCgcccatccacatcttcgtca	11	14	2	0	rs139895939		TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr1:29189500C>T	uc001brf.1	+	3	1066	c.824C>T	c.(823-825)GCG>GTG	p.A275V		NM_000911	NP_000902	P41143	OPRD_HUMAN	opioid receptor, delta 1	275	Helical; Name=6; (Potential).				immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	GTGTGTTGGGCGCCCATCCAC	0.672													T	29189500	T	T	29189500	3	4	276	1	0	0	0	0	1	0	0	0	10884	768	27	1	834	1	OPRD1	1	29189500	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	12928508	29189500	220061121	3	19826											
PTPN22	26191	broad.mit.edu	37	chr1	114380721	114380721	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttgaattaaaatatcttcctGctgcatttacaggtttagaa	6	6	1	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr1:114380721G>A	uc001eds.2	-	13	1431	c.1301C>T	c.(1300-1302)GCA>GTA	p.A434V	PTPN22_uc009wgq.2_Missense_Mutation_p.A379V|PTPN22_uc010owo.1_Missense_Mutation_p.A190V|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.A434V|PTPN22_uc009wgs.2_Missense_Mutation_p.A307V|PTPN22_uc001edu.2_Missense_Mutation_p.A434V	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	434					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATATCTTCCTGCTGCATTTAC	0.408													A	114380721	A	A	114380721	3	1	276	1	0	0	0	0	1	0	0	0	12787	1319	46	3	1181	3	PTPN22	1	114380721	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	85191221	114380721	134869900	4	19827											
IGSF3	3321	broad.mit.edu	37	chr1	117142794	117142794	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccactggacccctccgtcccGggtgaaggtcaccaagtcat	10	16	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr1:117142794G>A	uc001egr.1	-	7	2503	c.1798C>T	c.(1798-1800)CGG>TGG	p.R600W	IGSF3_uc001egq.1_Missense_Mutation_p.R620W|IGSF3_uc001egs.1_Missense_Mutation_p.R273W	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	600	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CCTCCGTCCCGGGTGAAGGTC	0.622													A	117142794	A	A	117142794	3	1	276	1	0	0	0	0	1	0	0	0	7601	1115	39	2	1806	2	IGSF3	1	117142794	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	2762073	117142794	132107827	5	19828											
VTCN1	79679	broad.mit.edu	37	chr1	117690323	117690323	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgagaggcagaagtgcccagCtgatggcaaagaaagaagag	15	6	0	6			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr1:117690323C>A	uc001ehb.2	-	5	878	c.806G>T	c.(805-807)AGC>ATC	p.S269I	VTCN1_uc001ehc.2_Missense_Mutation_p.S174I|VTCN1_uc009whf.1_Missense_Mutation_p.S153I	NM_024626	NP_078902	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation	269	Helical; (Potential).					integral to membrane|plasma membrane					0	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		AAGTGCCCAGCTGATGGCAAA	0.448													A	117690323	A	A	117690323	3	1	276	1	0	0	0	0	1	0	0	0	17231	797	28	5	46	5	VTCN1	1	117690323	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	547529	117690323	131560298	6	19829											
C1orf110	339512	broad.mit.edu	37	chr1	162829260	162829260	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaagtcttaccttgctgcaaCctctgcagttctttttggag	8	10	3	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr1:162829260C>A	uc001gck.2	-	2	352	c.177G>T	c.(175-177)AGG>AGT	p.R59S	C1orf110_uc009wux.1_Missense_Mutation_p.R59S	NM_178550	NP_848645	Q86UF4	CA110_HUMAN	hypothetical protein LOC339512	59	Potential.										0						CTTGCTGCAACCTCTGCAGTT	0.547													A	162829260	A	A	162829260	3	1	276	1	0	0	0	0	1	0	0	0	1983	506	18	5	743	5	C1orf110	1	162829260	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	45138937	162829260	86421361	7	19830											
CYB5R1	51706	broad.mit.edu	37	chr1	202932844	202932844	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggcccggatcagctgtagcaTtggggtgattcctgcatgaa	14	9	1	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr1:202932844T>C	uc001gyt.2	-	7	642	c.571A>G	c.(571-573)ATG>GTG	p.M191V	CYB5R1_uc010pqe.1_RNA	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	191	FAD (By similarity).				sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)			AGCTGTAGCATTGGGGTGATT	0.512													C	202932844	C	C	202932844	3	2	276	1	0	0	0	0	1	0	0	0	4126	1493	52	4	358	4	CYB5R1	1	202932844	Missense_Mutation	SNP	T	TCGA-76-6660-01A-11D-1845-08	40103584	202932844	46317777	8	19831											
SMYD3	64754	broad.mit.edu	37	chr1	246078867	246078867	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gcaacggaaacagtcacattCaaagcagtactggtccctca	8	12	3	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr1:246078867C>A	uc001ibl.2	-	8	873	c.778G>T	c.(778-780)GAA>TAA	p.E260*	SMYD3_uc001ibk.2_Nonsense_Mutation_p.E201*|SMYD3_uc001ibi.2_Nonsense_Mutation_p.E71*|SMYD3_uc001ibj.2_Nonsense_Mutation_p.E71*	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	260						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		CAGTCACATTCAAAGCAGTAC	0.512													A	246078867	A	A	246078867	4	1	276	1	0	0	0	0	0	1	0	0	14823	835	29	5	528	5	SMYD3	1	246078867	Nonsense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	43146023	246078867	3171754	9	19832											
SEMA4F	10505	broad.mit.edu	37	chr2	74900663	74900663	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agagcagtgggtcgtgccgaGgactggattcggacagatac	16	8	0	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr2:74900663G>A	uc002sna.1	+	6	741	c.630G>A	c.(628-630)GAG>GAA	p.E210E	SEMA4F_uc010ysb.1_3'UTR|SEMA4F_uc010ffq.1_Silent_p.E177E|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Intron	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	210	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GTCGTGCCGAGGACTGGATTC	0.612													A	74900663	A	A	74900663	2	1	276	1	0	0	0	0	0	0	0	1	14035	991	35	3		3	SEMA4F	2	74900663	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08		74900663	168298710	10	19833											
REV1	51455	broad.mit.edu	37	chr2	100065960	100065960	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gttttctcaattcctcagcgGaaggatctgcaaaatttata	7	8	3	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr2:100065960G>C	uc002tad.2	-	4	400	c.188C>G	c.(187-189)TCC>TGC	p.S63C	REV1_uc002tac.2_Missense_Mutation_p.S63C|REV1_uc002tae.1_Missense_Mutation_p.S42C	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	63	BRCT.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						TTCCTCAGCGGAAGGATCTGC	0.313								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					C	100065960	C	C	100065960	3	2	276	1	0	0	0	0	1	0	0	0	13239	1174	41	5	3647	5	REV1	2	100065960	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	25165297	100065960	143133413	11	19834											
CNTNAP5	129684	broad.mit.edu	37	chr2	125530548	125530548	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggagcaccagggagacgtcGgaggagggccattttcgact	16	9	0	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr2:125530548G>A	uc002tno.2	+	17	3067	c.2703G>A	c.(2701-2703)TCG>TCA	p.S901S	CNTNAP5_uc010flu.2_Silent_p.S902S	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	901	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGGAGACGTCGGAGGAGGGCC	0.532													A	125530548	A	A	125530548	2	1	276	1	0	0	0	0	0	0	0	1	3650	1103	39	2		2	CNTNAP5	2	125530548	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	25464588	125530548	117668825	12	19835											
TTN	7273	broad.mit.edu	37	chr2	179458769	179458769	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtatttgccggaatctgaacGtttggccttgatcttctcta	9	9	3	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr2:179458769G>A	uc010zfg.1	-	246	50871	c.50647C>T	c.(50647-50649)CGT>TGT	p.R16883C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R10578C|TTN_uc010zfi.1_Missense_Mutation_p.R10511C|TTN_uc010zfj.1_Missense_Mutation_p.R10386C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17810							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAATCTGAACGTTTGGCCTTG	0.423													A	179458769	A	A	179458769	3	1	276	1	0	0	0	0	1	0	0	0	16732	1145	40	1	49892	1	TTN	2	179458769	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	53928221	179458769	63740604	13	19836											
CCDC141	285025	broad.mit.edu	37	chr2	179720232	179720232	+	Frame_Shift_Del	DEL	T	-	-													atttaagaaagaatcagaggTtttattactaactttttcca							TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr2:179720232delT	uc002unf.1	-	9	1234	c.1177delA	c.(1177-1179)ACCfs	p.T393fs		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	393	Potential.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GAATCAGAGGTTTTATTACTA	0.284													-	179720232	-	-	179720232	7	5	276	1	0	1	0	1	0	0	0	0	2775	1725	60	0	1470	0	CCDC141	2	179720232	Frame_Shift_Del	DEL	T	TCGA-76-6660-01A-11D-1845-08	261463	179720232	63479141	14	19837											
WDR75	84128	broad.mit.edu	37	chr2	190313200	190313200	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggacacagaaatctggtgaCtggaatccagcttaacccca	9	11	1	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr2:190313200C>T	uc002uql.1	+	2	242	c.182C>T	c.(181-183)ACT>ATT	p.T61I	WDR75_uc002uqm.1_5'UTR|WDR75_uc002uqn.1_5'UTR	NM_032168	NP_115544	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	61	WD 2.					nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			AATCTGGTGACTGGAATCCAG	0.398													T	190313200	T	T	190313200	3	4	276	1	0	0	0	0	1	0	0	0	17322	565	20	3	188	3	WDR75	2	190313200	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	10592968	190313200	52886173	15	19838											
TRIP12	9320	broad.mit.edu	37	chr2	230683176	230683176	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaataactgcctgaagctgTtgactttcatcactggcttg	8	10	3	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr2:230683176T>C	uc002vpw.1	-	8	1468	c.1359A>G	c.(1357-1359)CAA>CAG	p.Q453Q	TRIP12_uc002vpx.1_Silent_p.Q501Q|TRIP12_uc002vpy.1_Silent_p.Q156Q|TRIP12_uc010zlz.1_Intron|TRIP12_uc010fxh.1_Silent_p.Q459Q	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	453					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CCTGAAGCTGTTGACTTTCAT	0.373													C	230683176	C	C	230683176	2	2	276	1	0	0	0	0	0	0	0	1	16553	1722	60	4		4	TRIP12	2	230683176	Silent	SNP	T	TCGA-76-6660-01A-11D-1845-08	40369976	230683176	12516197	16	19839											
ILKAP	80895	broad.mit.edu	37	chr2	239079263	239079263	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggccagcctgttgcaggctgCttcgtagcgggcgtcggctg	17	12	0	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr2:239079263C>T	uc002vxv.2	-	12	1223	c.1093G>A	c.(1093-1095)GCA>ACA	p.A365T	ILKAP_uc010zns.1_Missense_Mutation_p.A297T|ILKAP_uc002vxw.2_Missense_Mutation_p.A245T	NM_030768	NP_110395	Q9H0C8	ILKAP_HUMAN	integrin-linked kinase-associated protein	365	PP2C-like.					cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			ovary(3)	3		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)		TTGCAGGCTGCTTCGTAGCGG	0.637													T	239079263	T	T	239079263	3	4	276	1	0	0	0	0	1	0	0	0	7714	797	28	3	89	3	ILKAP	2	239079263	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	8396087	239079263	4120110	17	19840											
CNTN4	152330	broad.mit.edu	37	chr3	3076439	3076439	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtatgtcattcaagccaggaCtccattctccgtgggctggc	11	12	3	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr3:3076439C>T	uc003bpc.2	+	16	2128	c.1907C>T	c.(1906-1908)ACT>ATT	p.T636I	CNTN4_uc003bpb.1_Missense_Mutation_p.T307I|CNTN4_uc003bpd.1_Missense_Mutation_p.T636I|CNTN4_uc003bpe.2_Missense_Mutation_p.T308I|CNTN4_uc003bpf.2_Missense_Mutation_p.T307I	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	636	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CAAGCCAGGACTCCATTCTCC	0.532													T	3076439	T	T	3076439	3	4	276	1	0	0	0	0	1	0	0	0	3643	565	20	3	1961	3	CNTN4	3	3076439	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08		3076439	194945991	18	19841											
ITIH4	3700	broad.mit.edu	37	chr3	52853785	52853785	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	actaccttgtctattccatcCtcttcttggagaaaaggaag	7	10	3	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr3:52853785C>T	uc003dfz.2	-	16	1972	c.1936G>A	c.(1936-1938)GGA>AGA	p.G646R	ITIH4_uc011bel.1_Intron|ITIH4_uc003dfy.2_Intron|ITIH4_uc011bem.1_Missense_Mutation_p.G651R|ITIH4_uc011ben.1_Intron	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	646					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CTATTCCATCCTCTTCTTGGA	0.547													T	52853785	T	T	52853785	3	4	276	1	0	0	0	0	1	0	0	0	7906	690	24	3	892	3	ITIH4	3	52853785	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	49777346	52853785	145168645	19	19842											
ROBO1	6091	broad.mit.edu	37	chr3	78683176	78683176	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggatagttggaggaactgtGtcatttgctcgataatctag	13	5	2	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr3:78683176G>A	uc003dqe.2	-	24	3598	c.3390C>T	c.(3388-3390)GAC>GAT	p.D1130D	ROBO1_uc003dqb.2_Silent_p.D1091D|ROBO1_uc003dqc.2_Silent_p.D1030D|ROBO1_uc003dqd.2_Silent_p.D1085D|ROBO1_uc010hoh.2_Silent_p.D322D|ROBO1_uc011bgl.1_Silent_p.D702D	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1130	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GAGGAACTGTGTCATTTGCTC	0.393													A	78683176	A	A	78683176	2	1	276	1	0	0	0	0	0	0	0	1	13513	1368	48	3		3	ROBO1	3	78683176	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	25829391	78683176	119339254	20	19843											
ARL6	84100	broad.mit.edu	37	chr3	97499015	97499015	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tcttaaaggctcaatctcaaAatatccttccaacaatagga	4	10	3	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr3:97499015A>T	uc003drv.2	+	4	449	c.136A>T	c.(136-138)AAT>TAT	p.N46Y	ARL6_uc003drw.2_RNA|ARL6_uc003dru.2_Missense_Mutation_p.N46Y|ARL6_uc010hoy.2_Missense_Mutation_p.N46Y	NM_177976	NP_816931	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	46					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		TCAATCTCAAAATATCCTTCC	0.308									Bardet-Biedl_syndrome				T	97499015	T	T	97499015	3	4	276	1	0	0	0	0	1	0	0	0	941	14	1	5	142	5	ARL6	3	97499015	Missense_Mutation	SNP	A	TCGA-76-6660-01A-11D-1845-08	18815839	97499015	100523415	21	19844											
NPHP3	27031	broad.mit.edu	37	chr3	132432101	132432101	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aaaaaatatcccattgtctcGcacattctcttaagtttagg	5	9	2	0	rs138124482		TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr3:132432101G>A	uc003epe.1	-	6	1064	c.987C>T	c.(985-987)TGC>TGT	p.C329C	NPHP3_uc003epf.1_Silent_p.C84C	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	329					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CCATTGTCTCGCACATTCTCT	0.289													A	132432101	A	A	132432101	2	1	276	1	0	0	0	0	0	0	0	1	10580	1079	38	1		1	NPHP3	3	132432101	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	34933086	132432101	65590329	22	19845											
KIAA0226	9711	broad.mit.edu	37	chr3	197431552	197431552	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccatcagcactgctctggtcGttctcgtgcacgctgatgaa	10	13	3	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr3:197431552G>A	uc003fyc.2	-	4	507	c.324C>T	c.(322-324)AAC>AAT	p.N108N	KIAA0226_uc003fyd.3_Silent_p.N48N|KIAA0226_uc003fye.1_5'Flank|KIAA0226_uc003fyf.2_Translation_Start_Site|KIAA0226_uc003fyg.2_Silent_p.N101N	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	108	RUN.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		TGCTCTGGTCGTTCTCGTGCA	0.567													A	197431552	A	A	197431552	2	1	276	1	0	0	0	0	0	0	0	1	8162	1136	40	1		1	KIAA0226	3	197431552	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	64999451	197431552	590878	23	19846											
TACC3	10460	broad.mit.edu	37	chr4	1729779	1729779	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcacaaagcggagactcCgcacggagccgaggaagaat	13	12	0	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr4:1729779C>T	uc003gdo.2	+	4	758	c.650C>T	c.(649-651)CCG>CTG	p.P217L	TACC3_uc010ibz.2_Missense_Mutation_p.P217L|TACC3_uc003gdp.2_Intron	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	217						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			GCGGAGACTCCGCACGGAGCC	0.597													T	1729779	T	T	1729779	3	4	276	1	0	0	0	0	1	0	0	0	15500	652	23	2	660	2	TACC3	4	1729779	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08		1729779	189424497	24	19847											
SLIT2	9353	broad.mit.edu	37	chr4	20597371	20597371	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactgcgacatcgattttgaCgactgccaagacaacaagtg	9	11	0	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr4:20597371C>T	uc003gpr.1	+	31	3438	c.3234C>T	c.(3232-3234)GAC>GAT	p.D1078D	SLIT2_uc003gps.1_Silent_p.D1070D	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1078	EGF-like 5; calcium-binding (Potential).				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding	p.D1078D(1)		central_nervous_system(4)|skin(4)|ovary(3)	11						TCGATTTTGACGACTGCCAAG	0.468													T	20597371	T	T	20597371	2	4	276	1	0	0	0	0	0	0	0	1	14740	535	19	1		1	SLIT2	4	20597371	Silent	SNP	C	TCGA-76-6660-01A-11D-1845-08	18867592	20597371	170556905	25	19848											
PALLD	23022	broad.mit.edu	37	chr4	169845564	169845564	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cactcactcacagcactgacCgagtgaggtaagactgcaca	9	13	2	3			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr4:169845564C>T	uc011cjx.1	+	19	3428	c.3217C>T	c.(3217-3219)CGA>TGA	p.R1073*	CBR4_uc011cjy.1_Intron|PALLD_uc003iru.2_Nonsense_Mutation_p.R1056*|PALLD_uc003irv.2_Nonsense_Mutation_p.R674*|PALLD_uc003irw.2_Nonsense_Mutation_p.R558*|PALLD_uc003irx.2_Nonsense_Mutation_p.R282*	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	1280	Ig-like C2-type 5.|Interaction with EZR.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CAGCACTGACCGAGTGAGGTA	0.418									Pancreatic_Cancer_Familial_Clustering_of				T	169845564	T	T	169845564	4	4	276	1	0	0	0	0	0	1	0	0	11407	644	23	2	3794	2	PALLD	4	169845564	Nonsense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	149248193	169845564	21308712	26	19849											
EDIL3	10085	broad.mit.edu	37	chr5	83402578	83402578	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggagtccaaaaagagctcgGtgagtagaggaagctgtgat	15	5	0	4			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr5:83402578G>T	uc003kio.1	-	6	959	c.540C>A	c.(538-540)CAC>CAA	p.H180Q	EDIL3_uc003kip.1_Missense_Mutation_p.H170Q	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	180	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		AAAGAGCTCGGTGAGTAGAGG	0.418													T	83402578	T	T	83402578	3	4	276	1	0	0	0	0	1	0	0	0	4915	1252	44	5	926	5	EDIL3	5	83402578	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08		83402578	97512682	27	19850											
WDR36	134430	broad.mit.edu	37	chr5	110461398	110461398	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	ctgattgtggtgggtccataGaagttatgcagagcttcttg	13	6	1	3			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr5:110461398G>C	uc003kpd.2	+	22	2728	c.2611G>C	c.(2611-2613)GAA>CAA	p.E871Q	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	871					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		TGGGTCCATAGAAGTTATGCA	0.443													C	110461398	C	C	110461398	3	2	276	1	0	0	0	0	1	0	0	0	17287	943	33	5	2697	5	WDR36	5	110461398	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	27058820	110461398	70453862	28	19851											
GABRA1	2554	broad.mit.edu	37	chr5	161300157	161300157	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtatttttccgtcaaagctGgaaggatgaaaggttaaaat	10	4	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr5:161300157G>A	uc010jiw.2	+	6	758	c.290G>A	c.(289-291)TGG>TAG	p.W97*	GABRA1_uc010jix.2_Nonsense_Mutation_p.W97*|GABRA1_uc010jiy.2_Nonsense_Mutation_p.W97*|GABRA1_uc003lyx.3_Nonsense_Mutation_p.W97*|GABRA1_uc010jiz.2_Nonsense_Mutation_p.W97*|GABRA1_uc010jja.2_Nonsense_Mutation_p.W97*|GABRA1_uc010jjb.2_Nonsense_Mutation_p.W97*	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	97	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CGTCAAAGCTGGAAGGATGAA	0.363													A	161300157	A	A	161300157	4	1	276	1	0	0	0	0	0	1	0	0	6160	1357	47	3	304	3	GABRA1	5	161300157	Nonsense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	50838759	161300157	19615103	29	19852											
N4BP3	23138	broad.mit.edu	37	chr5	177547670	177547670	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagctcaagaggggccttggCgatgaggacggctccaaccc	15	12	1	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr5:177547670C>T	uc003mik.1	+	3	1069	c.822C>T	c.(820-822)GGC>GGT	p.G274G	N4BP3_uc003mil.1_5'Flank	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	274						cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGGCCTTGGCGATGAGGACG	0.662													T	177547670	T	T	177547670	2	4	276	1	0	0	0	0	0	0	0	1	10113	755	27	1		1	N4BP3	5	177547670	Silent	SNP	C	TCGA-76-6660-01A-11D-1845-08	16247513	177547670	3367590	30	19853											
BTN2A2	10385	broad.mit.edu	37	chr6	26385257	26385257	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaacagcccagtttactgtcGtggggccagctaatcccatc	10	13	0	0	rs143653188	byFrequency	TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr6:26385257G>A	uc003nhq.2	+	3	195	c.109G>A	c.(109-111)GTG>ATG	p.V37M	BTN2A2_uc011dkf.1_Intron|BTN2A2_uc011dkg.1_Missense_Mutation_p.V37M|BTN2A2_uc003nhr.2_Intron|BTN2A2_uc011dkh.1_Intron|BTN2A2_uc003nhs.2_Missense_Mutation_p.V37M|BTN2A2_uc003nht.2_Missense_Mutation_p.V37M	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	37	Extracellular (Potential).|Ig-like V-type.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						GTTTACTGTCGTGGGGCCAGC	0.438													A	26385257	A	A	26385257	3	1	276	1	0	0	0	0	1	0	0	0	1561	1145	40	1	115	1	BTN2A2	6	26385257	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08		26385257	144729810	31	19854											
CUL9	23113	broad.mit.edu	37	chr6	43160945	43160945	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtgcagcaggctgggctggCggtgagtacattgggcctgg	20	8	0	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr6:43160945C>T	uc003ouk.2	+	9	2462	c.2387C>T	c.(2386-2388)GCG>GTG	p.A796V	CUL9_uc003oul.2_Missense_Mutation_p.A796V|CUL9_uc010jyk.2_5'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	796					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding	p.A796T(1)		ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GCTGGGCTGGCGGTGAGTACA	0.567													T	43160945	T	T	43160945	3	4	276	1	0	0	0	0	1	0	0	0	4061	782	27	1	2417	1	CUL9	6	43160945	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	16775688	43160945	127954122	32	19855											
BCKDHB	594	broad.mit.edu	37	chr6	80838915	80838915	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttgcctttggtggagtcttTagatgcactgttggcttgcg	14	7	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr6:80838915T>C	uc003pjd.2	+	3	379	c.312T>C	c.(310-312)TTT>TTC	p.F104F	BCKDHB_uc003pje.2_Silent_p.F104F	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	104					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		GTGGAGTCTTTAGATGCACTG	0.259													C	80838915	C	C	80838915	2	2	276	1	0	0	0	0	0	0	0	1	1360	1751	61	4		4	BCKDHB	6	80838915	Silent	SNP	T	TCGA-76-6660-01A-11D-1845-08	37677970	80838915	90276152	33	19856											
AHI1	54806	broad.mit.edu	37	chr6	135748441	135748441	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcagaatacatggctacttgTtctcctaaataaaaagagag	7	7	2	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr6:135748441T>C	uc003qgi.2	-	20	3012	c.2628A>G	c.(2626-2628)GAA>GAG	p.E876E	AHI1_uc003qgf.2_RNA|AHI1_uc003qgg.2_Silent_p.E326E|AHI1_uc003qgh.2_Silent_p.E876E|AHI1_uc003qgj.2_Silent_p.E876E|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Silent_p.E876E	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	876	WD 6.					adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TGGCTACTTGTTCTCCTAAAT	0.323													C	135748441	C	C	135748441	2	2	276	1	0	0	0	0	0	0	0	1	413	1722	60	4		4	AHI1	6	135748441	Silent	SNP	T	TCGA-76-6660-01A-11D-1845-08	54909526	135748441	35366626	34	19857											
RPS6KA2	6196	broad.mit.edu	37	chr6	166912027	166912027	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgaaggaccaccagtcggcaCtctgcgtgtgtcctcgccgg	13	15	1	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr6:166912027C>T	uc003qvb.1	-	8	935	c.716G>A	c.(715-717)AGT>AAT	p.S239N	RPS6KA2_uc011ego.1_Missense_Mutation_p.S150N|RPS6KA2_uc010kkl.1_Missense_Mutation_p.S150N|RPS6KA2_uc003qvc.1_Missense_Mutation_p.S247N|RPS6KA2_uc003qvd.1_Missense_Mutation_p.S264N	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	239	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CCAGTCGGCACTCTGCGTGTG	0.637													T	166912027	T	T	166912027	3	4	276	1	0	0	0	0	1	0	0	0	13651	565	20	3	1541	3	RPS6KA2	6	166912027	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	31163586	166912027	4203040	35	19858											
IKZF1	10320	broad.mit.edu	37	chr7	50358674	50358674	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gaccatggatgctgatgaggGtcaagacatgtcccaagttt	12	8	1	3			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr7:50358674G>T	uc003tow.3	+	3	185	c.17G>T	c.(16-18)GGT>GTT	p.G6V	IKZF1_uc003tox.3_Missense_Mutation_p.G6V|IKZF1_uc003toy.3_Missense_Mutation_p.G6V|IKZF1_uc011kck.1_Missense_Mutation_p.G6V|IKZF1_uc003tov.1_Missense_Mutation_p.G6V	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	6					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(24)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GCTGATGAGGGTCAAGACATG	0.433			D		ALL								T	50358674	T	T	50358674	3	4	276	1	0	0	0	0	1	0	0	0	7614	1261	44	5	19	5	IKZF1	7	50358674	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08		50358674	108779989	36	19859											
SEPT14	346288	broad.mit.edu	37	chr7	55912359	55912359	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaggatttgttatctttcaaGttagtattaaacaatgtgtc	8	4	2	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr7:55912359G>A	uc003tqz.2	-	4	345	c.228C>T	c.(226-228)AAC>AAT	p.N76N		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	76					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TATCTTTCAAGTTAGTATTAA	0.353													A	55912359	A	A	55912359	2	1	276	1	0	0	0	0	0	0	0	1	14063	1020	36	3		3	SEPT14	7	55912359	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	5553685	55912359	103226304	37	19860											
EIF4H	7458	broad.mit.edu	37	chr7	73609098	73609098	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggatgacttcttagggggcaGgggaggtagtcgcccaggcg	19	8	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr7:73609098G>A	uc003uad.1	+	6	505	c.497G>A	c.(496-498)AGG>AAG	p.R166K	RFC2_uc011kfa.1_Intron|EIF4H_uc010lbm.2_Intron|EIF4H_uc003uae.1_Missense_Mutation_p.R146K|EIF4H_uc003uaf.1_RNA	NM_022170	NP_071496	Q15056	IF4H_HUMAN	eukaryotic translation initiation factor 4H	166					interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0						TTAGGGGGCAGGGGAGGTAGT	0.542													A	73609098	A	A	73609098	3	1	276	1	0	0	0	0	1	0	0	0	5039	1000	35	3	519	3	EIF4H	7	73609098	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	17696739	73609098	85529565	38	19861											
MUC17	140453	broad.mit.edu	37	chr7	100683326	100683326	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tattaacaagtatacctgtcAgcaccacgccggtggccagt	9	12	1	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr7:100683326A>G	uc003uxp.1	+	3	8682	c.8629A>G	c.(8629-8631)AGC>GGC	p.S2877G	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2877	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|46.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TATACCTGTCAGCACCACGCC	0.478													G	100683326	G	G	100683326	3	3	276	1	0	0	0	0	1	0	0	0	9974	188	7	4	8639	4	MUC17	7	100683326	Missense_Mutation	SNP	A	TCGA-76-6660-01A-11D-1845-08	27074228	100683326	58455337	39	19862											
RELN	5649	broad.mit.edu	37	chr7	103338368	103338368	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcgagactatcttctaaaaCgacttgtctgtgagctgaat	9	8	3	3	rs114926265	byFrequency	TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr7:103338368C>T	uc003vca.2	-	10	1235	c.1075G>A	c.(1075-1077)GTT>ATT	p.V359I	RELN_uc010liz.2_Missense_Mutation_p.V359I	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	359					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCTTCTAAAACGACTTGTCTG	0.428													T	103338368	T	T	103338368	3	4	276	1	0	0	0	0	1	0	0	0	13220	536	19	1	9531	1	RELN	7	103338368	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	2655042	103338368	55800295	40	19863											
SLC26A3	1811	broad.mit.edu	37	chr7	107415299	107415299	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gttgcgcttgcgtagaattcGaagtggactaaagccaacct	11	9	0	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr7:107415299G>A	uc003ver.2	-	16	1907	c.1696C>T	c.(1696-1698)CGA>TGA	p.R566*	SLC26A3_uc003ves.2_Nonsense_Mutation_p.R531*	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	566	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						CGTAGAATTCGAAGTGGACTA	0.398													A	107415299	A	A	107415299	4	1	276	1	0	0	0	0	0	1	0	0	14518	1066	37	2	622	2	SLC26A3	7	107415299	Nonsense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	4076931	107415299	51723364	41	19864											
PPP1R3A	5506	broad.mit.edu	37	chr7	113558926	113558926	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaagaatcagaacctcgtctActtggttgaggggagaaacc	12	8	2	4			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr7:113558926A>C	uc010ljy.1	-	1	157	c.126T>G	c.(124-126)AGT>AGG	p.S42R		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	42					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						AACCTCGTCTACTTGGTTGAG	0.373													C	113558926	C	C	113558926	3	2	276	1	0	0	0	0	1	0	0	0	12371	388	14	5	3258	5	PPP1R3A	7	113558926	Missense_Mutation	SNP	A	TCGA-76-6660-01A-11D-1845-08	6143627	113558926	45579737	42	19865											
IMPDH1	3614	broad.mit.edu	37	chr7	128034510	128034510	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccccagtctcagcactcacCgaaggacagacaggctgcgg	11	16	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr7:128034510C>T	uc011kol.1	-	12	1545	c.1439G>A	c.(1438-1440)CGG>CAG	p.R480Q	IMPDH1_uc011kom.1_Missense_Mutation_p.R475Q|IMPDH1_uc003vmt.2_Missense_Mutation_p.R455Q|IMPDH1_uc003vmu.2_Missense_Mutation_p.R565Q|IMPDH1_uc003vmw.2_Missense_Mutation_p.R555Q|IMPDH1_uc011kon.1_Missense_Mutation_p.R532Q|IMPDH1_uc003vmv.2_Missense_Mutation_p.R529Q|IMPDH1_uc003vmx.2_Missense_Mutation_p.R488Q|IMPDH1_uc003vmy.2_Missense_Mutation_p.R496Q|uc011koo.1_5'Flank	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	480					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CAGCACTCACCGAAGGACAGA	0.582													T	128034510	T	T	128034510	3	4	276	1	0	0	0	0	1	0	0	0	7726	666	23	2	117	2	IMPDH1	7	128034510	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	14475584	128034510	31104153	43	19866											
KCNB2	9312	broad.mit.edu	37	chr8	73849104	73849104	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	tctgtcggaaacaagctccaAcaagtctttcgagaataagt	8	9	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr8:73849104A>T	uc003xzb.2	+	3	2102	c.1514A>T	c.(1513-1515)AAC>ATC	p.N505I		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	505	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ACAAGCTCCAACAAGTCTTTC	0.562													T	73849104	T	T	73849104	3	4	276	1	0	0	0	0	1	0	0	0	8013	43	2	5	1520	5	KCNB2	8	73849104	Missense_Mutation	SNP	A	TCGA-76-6660-01A-11D-1845-08		73849104	72514918	44	19867											
CSMD3	114788	broad.mit.edu	37	chr8	113256734	113256734	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	ggtataaatcagtgtataccCatgagatggaaggtccatcc	10	8	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr8:113256734C>G	uc003ynu.2	-	65	10450	c.10291G>C	c.(10291-10293)GGG>CGG	p.G3431R	CSMD3_uc003yns.2_Missense_Mutation_p.G2633R|CSMD3_uc003ynt.2_Missense_Mutation_p.G3391R|CSMD3_uc011lhx.1_Missense_Mutation_p.G3262R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3431	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGTGTATACCCATGAGATGGA	0.428										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			G	113256734	G	G	113256734	3	3	276	1	0	0	0	0	1	0	0	0	3946	594	21	5	860	5	CSMD3	8	113256734	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	39407630	113256734	33107288	45	19868											
GPR20	2843	broad.mit.edu	37	chr8	142367058	142367058	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgcatgctgaccacgtcaccGctgctgggctcacgctctcc	10	17	3	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr8:142367058G>A	uc003ywf.2	-	2	1055	c.966C>T	c.(964-966)AGC>AGT	p.S322S		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	322	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CCACGTCACCGCTGCTGGGCT	0.657													A	142367058	A	A	142367058	2	1	276	1	0	0	0	0	0	0	0	1	6680	1078	38	1		1	GPR20	8	142367058	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	29110324	142367058	3996964	46	19869											
TMEM2	23670	broad.mit.edu	37	chr9	74319626	74319626	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	ctgtggaaaggcagccttctGattaatacctcggagcacca	10	11	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr9:74319626G>A	uc011lsa.1	-	18	3619	c.3079C>T	c.(3079-3081)CAG>TAG	p.Q1027*	TMEM2_uc011lrz.1_Nonsense_Mutation_p.Q20*|TMEM2_uc010mos.2_Nonsense_Mutation_p.Q964*|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1027						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		GCAGCCTTCTGATTAATACCT	0.483													A	74319626	A	A	74319626	4	1	276	1	0	0	0	0	0	1	0	0	16118	1299	45	3	1100	3	TMEM2	9	74319626	Nonsense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08		74319626	66893805	47	19870											
ZNF883	169834	broad.mit.edu	37	chr9	115760403	115760403	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccgggtaaaggacttaccaCatattttacattcataaggt	7	8	1	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr9:115760403C>T	uc011lwy.1	-	5	1376	c.137G>A	c.(136-138)TGT>TAT	p.C46Y		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	46	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGACTTACCACATATTTTACA	0.373													T	115760403	T	T	115760403	3	4	276	1	0	0	0	0	1	0	0	0	18195	478	17	3	1004	3	ZNF883	9	115760403	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	41440777	115760403	25453028	48	19871											
ZNF883	169834	broad.mit.edu	37	chr9	115760511	115760511	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagtacagagatatgggttcGcggtcatataaattttctca	9	7	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr9:115760511G>A	uc011lwy.1	-	5	1268	c.29C>T	c.(28-30)GCG>GTG	p.A10V		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATATGGGTTCGCGGTCATATA	0.368													A	115760511	A	A	115760511	3	1	276	1	0	0	0	0	1	0	0	0	18195	1087	38	1	1112	1	ZNF883	9	115760511	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	108	115760511	25452920	49	19872											
PRPF4	9128	broad.mit.edu	37	chr9	116038922	116038922	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggaagagaaggagagggagcGtctggccaaaggagagtctg	19	5	2	3			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr9:116038922G>A	uc004bgx.2	+	2	175	c.125G>A	c.(124-126)CGT>CAT	p.R42H	FKBP15_uc010muu.1_5'Flank|CDC26_uc004bgw.2_5'Flank|PRPF4_uc004bgy.2_Missense_Mutation_p.R41H	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	42						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						GAGAGGGAGCGTCTGGCCAAA	0.458													A	116038922	A	A	116038922	3	1	276	1	0	0	0	0	1	0	0	0	12570	1145	40	1	131	1	PRPF4	9	116038922	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	278411	116038922	25174509	50	19873											
PKN3	29941	broad.mit.edu	37	chr9	131482499	131482499	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagctcctccagaagtgcccGgagaagcgcctcggggcagg	15	14	0	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr9:131482499G>A	uc004bvw.2	+	21	2787	c.2394G>A	c.(2392-2394)CCG>CCA	p.P798P	PKN3_uc010myh.2_Silent_p.P798P|PKN3_uc011mbk.1_Silent_p.P348P	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	protein kinase PKNbeta	798	Protein kinase.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			stomach(2)|lung(2)	4						AGAAGTGCCCGGAGAAGCGCC	0.657													A	131482499	A	A	131482499	2	1	276	1	0	0	0	0	0	0	0	1	11981	1103	39	2		2	PKN3	9	131482499	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	15443577	131482499	9730932	51	19874											
KCNT1	57582	broad.mit.edu	37	chr9	138662162	138662162	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggagggacaggagtctccGgagcagtggcagcgcatgta	18	8	1	0	rs138352399	byFrequency	TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr9:138662162G>A	uc011mdq.1	+	17	1712	c.1638G>A	c.(1636-1638)CCG>CCA	p.P546P	KCNT1_uc011mdr.1_Silent_p.P373P|KCNT1_uc010nbf.2_Silent_p.P501P|KCNT1_uc004cgo.1_Silent_p.P295P	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	546						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		AGGAGTCTCCGGAGCAGTGGC	0.682													A	138662162	A	A	138662162	2	1	276	1	0	0	0	0	0	0	0	1	8091	1103	39	2		2	KCNT1	9	138662162	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	7179663	138662162	2551269	52	19875											
OPTN	10133	broad.mit.edu	37	chr10	13174131	13174131	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agagaaaattcatgaggaaaAggagcaactggcattgcagc	12	6	1	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr10:13174131A>G	uc001ilu.1	+	14	1904	c.1466A>G	c.(1465-1467)AAG>AGG	p.K489R	OPTN_uc001ilv.1_Missense_Mutation_p.K489R|OPTN_uc001ilw.1_Missense_Mutation_p.K489R|OPTN_uc001ilx.1_Missense_Mutation_p.K489R|OPTN_uc001ily.1_Missense_Mutation_p.K483R|OPTN_uc010qbr.1_Missense_Mutation_p.K432R|OPTN_uc001ilz.1_Missense_Mutation_p.K483R	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	489	Potential.|Interaction with MYO6.|Interaction with HD.				cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2						CATGAGGAAAAGGAGCAACTG	0.443													G	13174131	G	G	13174131	3	3	276	1	0	0	0	0	1	0	0	0	10889	72	3	4	1508	4	OPTN	10	13174131	Missense_Mutation	SNP	A	TCGA-76-6660-01A-11D-1845-08		13174131	122360616	53	19876											
CCDC7	221016	broad.mit.edu	37	chr10	32780862	32780862	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aataatagaaactgctcattCaatgactaatcgatttaatg	5	6	2	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr10:32780862C>T	uc001iwj.2	+	10	1379	c.809C>T	c.(808-810)TCA>TTA	p.S270L	CCDC7_uc009xlu.1_Intron|CCDC7_uc001iwk.2_Missense_Mutation_p.S270L|CCDC7_uc009xlv.2_Intron|CCDC7_uc009xlw.1_RNA|CCDC7_uc009xlx.1_Intron|CCDC7_uc009xly.1_Intron	NM_145023	NP_659460	Q96M83	CCDC7_HUMAN	coiled-coil domain containing 7	270											0		Breast(68;0.000207)|Prostate(175;0.0107)				ACTGCTCATTCAATGACTAAT	0.259													T	32780862	T	T	32780862	3	4	276	1	0	0	0	0	1	0	0	0	2842	838	29	3	843	3	CCDC7	10	32780862	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	19606731	32780862	102753885	54	19877											
SLC18A3	6572	broad.mit.edu	37	chr10	50819867	50819867	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctgcagtggctgtacggcGcgcttgggctggctgtgatc	16	11	0	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr10:50819867G>A	uc001jhw.2	+	1	1521	c.1081G>A	c.(1081-1083)GCG>ACG	p.A361T	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	361	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GCTGTACGGCGCGCTTGGGCT	0.687													A	50819867	A	A	50819867	3	1	276	1	0	0	0	0	1	0	0	0	14427	1087	38	1	1083	1	SLC18A3	10	50819867	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	18039005	50819867	84714880	55	19878											
LIPF	8513	broad.mit.edu	37	chr10	90428330	90428330	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cttaggccagagacctgttgTgtttttgcagcatggtttgc	12	8	0	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr10:90428330T>A	uc001kfg.1	+	4	405	c.239T>A	c.(238-240)GTG>GAG	p.V80E	LIPF_uc009xtk.2_Missense_Mutation_p.V80E|LIPF_uc001kfh.1_Intron|LIPF_uc010qmt.1_Missense_Mutation_p.V90E|LIPF_uc010qmu.1_Intron	NM_004190	NP_004181	P07098	LIPG_HUMAN	lipase, gastric precursor	80					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity				0		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		AGACCTGTTGTGTTTTTGCAG	0.408													A	90428330	A	A	90428330	3	1	276	1	0	0	0	0	1	0	0	0	8822	1696	59	5	249	5	LIPF	10	90428330	Missense_Mutation	SNP	T	TCGA-76-6660-01A-11D-1845-08	39608463	90428330	45106417	56	19879											
DMBT1	1755	broad.mit.edu	37	chr10	124395540	124395540	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgcaactatgattatattgaAgttttcgatggcccctaccg	8	9	0	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr10:124395540A>G	uc001lgk.1	+	50	6301	c.6195A>G	c.(6193-6195)GAA>GAG	p.E2065E	DMBT1_uc001lgl.1_Silent_p.E2055E|DMBT1_uc001lgm.1_Silent_p.E1437E|DMBT1_uc009xzz.1_Silent_p.E2064E|DMBT1_uc010qtx.1_Silent_p.E785E|DMBT1_uc009yab.1_Silent_p.E768E|DMBT1_uc009yac.1_Silent_p.E359E	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2065	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATTATATTGAAGTTTTCGATG	0.507													G	124395540	G	G	124395540	2	3	276	1	0	0	0	0	0	0	0	1	4577	69	3	4		4	DMBT1	10	124395540	Silent	SNP	A	TCGA-76-6660-01A-11D-1845-08	33967210	124395540	11139207	57	19880											
NLRP14	338323	broad.mit.edu	37	chr11	7083705	7083705	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	attctgtgtgatgctttgagAtatccaaactgtaacattca	7	7	2	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr11:7083705A>G	uc001mfb.1	+	10	3269	c.2946A>G	c.(2944-2946)AGA>AGG	p.R982R		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	982					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ATGCTTTGAGATATCCAAACT	0.403													G	7083705	G	G	7083705	2	3	276	1	0	0	0	0	0	0	0	1	10476	330	12	4		4	NLRP14	11	7083705	Silent	SNP	A	TCGA-76-6660-01A-11D-1845-08		7083705	127922811	58	19881											
RNF141	50862	broad.mit.edu	37	chr11	10536581	10536581	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgctccagtcatctgtaggCgacaaatagggcaattcctg	10	10	2	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr11:10536581C>T	uc001mis.1	-	6	728	c.575G>A	c.(574-576)CGC>CAC	p.R192H	RNF141_uc009yga.1_RNA	NM_016422	NP_057506	Q8WVD5	RN141_HUMAN	ring finger protein 141	192	RING-type.						zinc ion binding				0				all cancers(16;4.63e-08)|Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.064)		CATCTGTAGGCGACAAATAGG	0.378													T	10536581	T	T	10536581	3	4	276	1	0	0	0	0	1	0	0	0	13444	768	27	1	121	1	RNF141	11	10536581	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	3452876	10536581	124469935	59	19882											
WT1	7490	broad.mit.edu	37	chr11	32421505	32421505	+	Silent	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtgctcacctgaatgcctcTgaagacaccgtgcgtgtgta	11	11	2	3			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr11:32421505T>G	uc001mtn.1	-	6	1283	c.1087A>C	c.(1087-1089)AGA>CGA	p.R363R	WT1_uc001mtl.1_Silent_p.R151R|WT1_uc001mtm.1_Silent_p.R134R|WT1_uc001mto.1_Silent_p.R363R|WT1_uc001mtp.1_Silent_p.R346R|WT1_uc001mtq.1_Silent_p.R346R|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	295					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			TGAATGCCTCTGAAGACACCG	0.557			D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				G	32421505	G	G	32421505	2	3	276	1	0	0	0	0	0	0	0	1	17405	1588	55	5		5	WT1	11	32421505	Silent	SNP	T	TCGA-76-6660-01A-11D-1845-08	21884924	32421505	102585011	60	19883											
CHRM1	1128	broad.mit.edu	37	chr11	62677224	62677224	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggagtgcggtgcacggagCcagggcgcttggggatcttg	20	8	1	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr11:62677224C>T	uc001nwi.2	-	2	1750	c.1349G>A	c.(1348-1350)GGC>GAC	p.G450D		NM_000738	NP_000729	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	450	Cytoplasmic (Potential).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding				0					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	GTGCACGGAGCCAGGGCGCTT	0.657													T	62677224	T	T	62677224	3	4	276	1	0	0	0	0	1	0	0	0	3376	739	26	3	37	3	CHRM1	11	62677224	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	30255719	62677224	72329292	61	19884											
STIP1	10963	broad.mit.edu	37	chr11	63961718	63961718	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accgctttgaagaagccaagCgaacctatgaggagggctta	12	9	0	3			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr11:63961718C>T	uc001nyk.1	+	3	424	c.277C>T	c.(277-279)CGA>TGA	p.R93*	STIP1_uc001nyj.2_Nonsense_Mutation_p.R93*|STIP1_uc010rnb.1_Intron	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	93	TPR 3.				axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3						AGAAGCCAAGCGAACCTATGA	0.468													T	63961718	T	T	63961718	4	4	276	1	0	0	0	0	0	1	0	0	15284	760	27	1	287	1	STIP1	11	63961718	Nonsense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	1284494	63961718	71044798	62	19885											
GRAMD1B	57476	broad.mit.edu	37	chr11	123471245	123471245	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tccggctctggcagaatgctCtccttgaaaaggtaagtacg	11	10	2	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr11:123471245C>G	uc001pyx.2	+	7	939	c.610C>G	c.(610-612)CTC>GTC	p.L204V	GRAMD1B_uc001pyw.2_Missense_Mutation_p.L211V|GRAMD1B_uc010rzw.1_Missense_Mutation_p.L164V|GRAMD1B_uc010rzx.1_Missense_Mutation_p.L164V|GRAMD1B_uc009zbe.1_Missense_Mutation_p.L200V	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	204						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		GCAGAATGCTCTCCTTGAAAA	0.458													G	123471245	G	G	123471245	3	3	276	1	0	0	0	0	1	0	0	0	6748	913	32	5	636	5	GRAMD1B	11	123471245	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	59509527	123471245	11535271	63	19886											
OVCH1	341350	broad.mit.edu	37	chr12	29630051	29630051	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctacctttataatgtgcttcTctggagcacaaatgaaccaa	6	10	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr12:29630051T>C	uc001rix.1	-	12	1361	c.1361A>G	c.(1360-1362)GAG>GGG	p.E454G		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	454	CUB 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					AATGTGCTTCTCTGGAGCACA	0.393													C	29630051	C	C	29630051	3	2	276	1	0	0	0	0	1	0	0	0	11323	1551	54	4	2111	4	OVCH1	12	29630051	Missense_Mutation	SNP	T	TCGA-76-6660-01A-11D-1845-08		29630051	104221844	64	19887											
H3F3C	440093	broad.mit.edu	37	chr12	31944946	31944946	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cggtcgacttctgataacgaCgaatctctcgaagcgccacg	10	13	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr12:31944946C>T	uc001rkr.2	-	1	230	c.155G>A	c.(154-156)CGT>CAT	p.R52H		NM_001013699	NP_001013721	Q6NXT2	H3C_HUMAN	histone H3-like	52					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CTGATAACGACGAATCTCTCG	0.582										HNSCC(67;0.2)			T	31944946	T	T	31944946	3	4	276	1	0	0	0	0	1	0	0	0	6935	536	19	1	256	1	H3F3C	12	31944946	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	2314895	31944946	101906949	65	19888											
GALNT6	11226	broad.mit.edu	37	chr12	51773383	51773383	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	attgaatctctaaggttgttCatggcctccagcatgaggtc	10	9	2	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr12:51773383C>T	uc001ryk.2	-	2	408	c.183G>A	c.(181-183)ATG>ATA	p.M61I	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Missense_Mutation_p.M61I|GALNT6_uc010snh.1_Missense_Mutation_p.M61I	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	61	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						TAAGGTTGTTCATGGCCTCCA	0.552													T	51773383	T	T	51773383	3	4	276	1	0	0	0	0	1	0	0	0	6217	826	29	3	1725	3	GALNT6	12	51773383	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	19828437	51773383	82078512	66	19889											
OR6C1	390321	broad.mit.edu	37	chr12	55714592	55714592	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tttctccatattagaaatttCgttcacaaccgtcagtatac	4	10	3	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr12:55714592C>T	uc010spi.1	+	1	209	c.209C>T	c.(208-210)TCG>TTG	p.S70L		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						TTAGAAATTTCGTTCACAACC	0.378													T	55714592	T	T	55714592	3	4	276	1	0	0	0	0	1	0	0	0	11190	893	31	2	211	2	OR6C1	12	55714592	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	3941209	55714592	78137303	67	19890											
GLT8D2	83468	broad.mit.edu	37	chr12	104387178	104387178	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tgaaatacttacccaggtgcCttatgtgccacagggggtta	11	9	0	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr12:104387178C>G	uc001tkh.1	-	10	1278	c.872G>C	c.(871-873)AGG>ACG	p.R291T	GLT8D2_uc001tki.1_Missense_Mutation_p.R291T	NM_031302	NP_112592	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	291	Lumenal (Potential).					integral to membrane	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2						ACCCAGGTGCCTTATGTGCCA	0.353													G	104387178	G	G	104387178	3	3	276	1	0	0	0	0	1	0	0	0	6470	681	24	5	185	5	GLT8D2	12	104387178	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	48672586	104387178	29464717	68	19891											
DCLK1	9201	broad.mit.edu	37	chr13	36686060	36686060	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actcccgagtccagcttgatGgcatcggtgatatcggtgag	13	10	0	3			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr13:36686060G>A	uc001uvf.2	-	3	902	c.669C>T	c.(667-669)GCC>GCT	p.A223A		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	223	Doublecortin 2.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CCAGCTTGATGGCATCGGTGA	0.488													A	36686060	A	A	36686060	2	1	276	1	0	0	0	0	0	0	0	1	4291	1335	47	3		3	DCLK1	13	36686060	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08		36686060	78483818	69	19892											
SPG20	23111	broad.mit.edu	37	chr13	36909291	36909291	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	caaaaaaaatctgtactccaTttggtatcaaaatcaattca	3	8	4	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr13:36909291T>C	uc001uvn.2	-	3	947	c.677A>G	c.(676-678)AAT>AGT	p.N226S	SPG20_uc010ten.1_Missense_Mutation_p.N226S|SPG20_uc001uvm.2_Missense_Mutation_p.N226S|SPG20_uc001uvo.2_Missense_Mutation_p.N226S|SPG20_uc001uvq.2_Missense_Mutation_p.N226S|SPG20_uc001uvp.2_Missense_Mutation_p.N226S	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	226					cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CTGTACTCCATTTGGTATCAA	0.423													C	36909291	C	C	36909291	3	2	276	1	0	0	0	0	1	0	0	0	15041	1493	52	4	1355	4	SPG20	13	36909291	Missense_Mutation	SNP	T	TCGA-76-6660-01A-11D-1845-08	223231	36909291	78260587	70	19893											
CTSG	1511	broad.mit.edu	37	chr14	25043946	25043946	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggtggcggatggctctgcGcgcagtgatgtgttgctggg	20	7	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr14:25043946G>A	uc001wpq.2	-	3	311	c.274C>T	c.(274-276)CGC>TGC	p.R92C		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	92	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		ATGGCTCTGCGCGCAGTGATG	0.532													A	25043946	A	A	25043946	3	1	276	1	0	0	0	0	1	0	0	0	4035	1087	38	1	505	1	CTSG	14	25043946	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08		25043946	82305594	71	19894											
ARHGAP5	394	broad.mit.edu	37	chr14	32560334	32560334	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcaaatgcctgaagggaaGctcaacgtagatggattttt	11	6	1	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr14:32560334G>A	uc001wrl.2	+	2	698	c.459G>A	c.(457-459)AAG>AAA	p.K153K	ARHGAP5_uc001wrm.2_Silent_p.K153K|ARHGAP5_uc001wrn.2_Silent_p.K153K|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	153					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CTGAAGGGAAGCTCAACGTAG	0.363													A	32560334	A	A	32560334	2	1	276	1	0	0	0	0	0	0	0	1	886	962	34	3		3	ARHGAP5	14	32560334	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	7516388	32560334	74789206	72	19895											
PTGDR	5729	broad.mit.edu	37	chr14	52735336	52735336	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatcacctcctgctgctggcGctgatgaccgtgctcttcac	10	15	3	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr14:52735336G>A	uc001wzq.2	+	1	906	c.804G>A	c.(802-804)GCG>GCA	p.A268A		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	268	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	TGCTGCTGGCGCTGATGACCG	0.687													A	52735336	A	A	52735336	2	1	276	1	0	0	0	0	0	0	0	1	12741	1074	38	1		1	PTGDR	14	52735336	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	20175002	52735336	54614204	73	19896											
CDAN1	146059	broad.mit.edu	37	chr15	43028860	43028860	+	Frame_Shift_Del	DEL	G	-	-													ccggggtcttggcgggggtcGggggcccctgcgggaggacg							TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr15:43028860delG	uc001zql.2	-	2	326	c.209delC	c.(208-210)CCGfs	p.P70fs	CDAN1_uc001zqk.2_5'Flank|CDAN1_uc010bcx.1_5'Flank|uc001zqm.2_5'Flank	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	70						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		GGCGGGGGTCGGGGGCCCCTG	0.736													-	43028860	-	-	43028860	7	5	276	1	0	1	0	1	0	0	0	0	3054	1116	39	0	3582	0	CDAN1	15	43028860	Frame_Shift_Del	DEL	G	TCGA-76-6660-01A-11D-1845-08		43028860	59502532	74	19897											
TGM7	116179	broad.mit.edu	37	chr15	43571424	43571424	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgcggatgagcttttcgtccGttagcttgtttctgtaattg	11	8	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr15:43571424G>A	uc001zrf.1	-	11	1735	c.1730C>T	c.(1729-1731)ACG>ATG	p.T577M		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	577					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	CTTTTCGTCCGTTAGCTTGTT	0.527													A	43571424	A	A	43571424	3	1	276	1	0	0	0	0	1	0	0	0	15832	1145	40	1	414	1	TGM7	15	43571424	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	542564	43571424	58959968	75	19898											
ATP8B4	79895	broad.mit.edu	37	chr15	50226281	50226281	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ctaaggaattcatgaactttGggatcacccattttaatgga	8	7	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr15:50226281G>T	uc001zxu.2	-	15	1528	c.1386C>A	c.(1384-1386)CCC>CCA	p.P462P	ATP8B4_uc010ber.2_Silent_p.P335P|ATP8B4_uc010ufd.1_Silent_p.P335P|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	462	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CATGAACTTTGGGATCACCCA	0.413													T	50226281	T	T	50226281	2	4	276	1	0	0	0	0	0	0	0	1	1197	1335	47	5		5	ATP8B4	15	50226281	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08	6654857	50226281	52305111	76	19899											
NEDD4	4734	broad.mit.edu	37	chr15	56207523	56207523	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atttgtgcaatctctgttgcTgtctcttgataaattatcca	6	8	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr15:56207523T>G	uc002adj.2	-	1	1807	c.1507A>C	c.(1507-1509)AGC>CGC	p.S503R	NEDD4_uc002adl.2_Intron|NEDD4_uc002adi.2_Missense_Mutation_p.S503R|NEDD4_uc010ugj.1_Missense_Mutation_p.S503R|NEDD4_uc010bfm.2_Missense_Mutation_p.S503R|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	503					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		TCTCTGTTGCTGTCTCTTGAT	0.338													G	56207523	G	G	56207523	3	3	276	1	0	0	0	0	1	0	0	0	10310	1580	55	5	2552	5	NEDD4	15	56207523	Missense_Mutation	SNP	T	TCGA-76-6660-01A-11D-1845-08	5981242	56207523	46323869	77	19900											
KIAA1024	23251	broad.mit.edu	37	chr15	79748562	79748562	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggacagcaagcaaaataccGtttcttatcaggacctgtgc	9	10	2	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr15:79748562G>A	uc002bew.1	+	2	148	c.73G>A	c.(73-75)GTT>ATT	p.V25I	KIAA1024_uc010unk.1_Missense_Mutation_p.V25I	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	25						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						GCAAAATACCGTTTCTTATCA	0.478													A	79748562	A	A	79748562	3	1	276	1	0	0	0	0	1	0	0	0	8205	1145	40	1	75	1	KIAA1024	15	79748562	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	23541039	79748562	22782830	78	19901											
ADAMTSL3	57188	broad.mit.edu	37	chr15	84659966	84659966	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	caatccgatgtcctgtaaaaGgtaagtgtggtcatttcagt	10	7	2	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr15:84659966G>T	uc002bjz.3	+	23	4197	c.3973G>T	c.(3973-3975)GGT>TGT	p.G1325C	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.G1325C|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.G1325C	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1325	Ig-like C2-type 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCCTGTAAAAGGTAAGTGTGG	0.502													T	84659966	T	T	84659966	3	4	276	1	0	0	0	0	1	0	0	0	276	1014	35	5	4059	5	ADAMTSL3	15	84659966	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	4911404	84659966	17871426	79	19902											
CHD9	80205	broad.mit.edu	37	chr16	53338029	53338037	+	In_Frame_Del	DEL	TAAAGGTAT	-	-													ctacctaggctcctagatgcTaaaggtattattctagagga							TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr16:53338029_53338037delTAAAGGTAT	uc002ehb.2	+	30	6275_6283	c.6111_6119delTAAAGGTAT	c.(6109-6120)GCTAAAGGTATT>GCT	p.KGI2038del	CHD9_uc002egy.2_In_Frame_Del_p.KGI2038del|CHD9_uc002ehc.2_In_Frame_Del_p.KGI2038del|CHD9_uc002ehf.2_In_Frame_Del_p.KGI1152del|CHD9_uc010cbw.2_Intron|CHD9_uc002ehg.1_In_Frame_Del_p.KGI44del	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2038_2040					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TCCTAGATGCTAAAGGTATTATTCTAGAG	0.407													-	53338037	-	-	53338029	7	5	276	1	0	1	0	1	0	0	0	0	3332	1509	53	0	6229	0	CHD9	16	53338029	In_Frame_Del	DEL	TAAAGGTAT	TCGA-76-6660-01A-11D-1845-08		53338029	37016724	80	19903											
MYH13	8735	broad.mit.edu	37	chr17	10209843	10209843	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgttcagcctcatctagaCggtgctgcaggtccttcacc	10	13	4	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr17:10209843C>T	uc002gmk.1	-	37	5489	c.5399G>A	c.(5398-5400)CGT>CAT	p.R1800H		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1800	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CTCATCTAGACGGTGCTGCAG	0.547													T	10209843	T	T	10209843	3	4	276	1	0	0	0	0	1	0	0	0	10032	536	19	1	437	1	MYH13	17	10209843	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08		10209843	70985367	81	19904											
MYH8	4626	broad.mit.edu	37	chr17	10322097	10322097	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cttgtaggggttgacggtgaCacagaagaggcctgagtagg	17	6	0	5			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr17:10322097C>A	uc002gmm.2	-	5	471	c.376G>T	c.(376-378)GTC>TTC	p.V126F	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	126	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTGACGGTGACACAGAAGAGG	0.512									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				A	10322097	A	A	10322097	3	1	276	1	0	0	0	0	1	0	0	0	10041	478	17	5	5581	5	MYH8	17	10322097	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	112254	10322097	70873113	82	19905											
XYLT2	64132	broad.mit.edu	37	chr17	48435599	48435599	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttgggaccccaaagagcgtcTtttccggaactttggggggt	14	9	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr17:48435599T>C	uc002iqo.2	+	10	2082	c.1973T>C	c.(1972-1974)CTT>CCT	p.L658P	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	658	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					AAAGAGCGTCTTTTCCGGAAC	0.443													C	48435599	C	C	48435599	3	2	276	1	0	0	0	0	1	0	0	0	17461	1609	56	4	2011	4	XYLT2	17	48435599	Missense_Mutation	SNP	T	TCGA-76-6660-01A-11D-1845-08	38113502	48435599	32759611	83	19906											
RNF43	54894	broad.mit.edu	37	chr17	56492699	56492699	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atacttgcctgcattaatttTccttctgctggagttatttc	6	9	1	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr17:56492699T>C	uc002iwf.2	-	1	2196	c.240A>G	c.(238-240)GGA>GGG	p.G80G	RNF43_uc010wnv.1_Silent_p.G80G|RNF43_uc002iwh.3_Silent_p.G80G|RNF43_uc002iwg.3_Silent_p.G80G|RNF43_uc010dcw.2_Intron	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	80	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCATTAATTTTCCTTCTGCTG	0.378													C	56492699	C	C	56492699	2	2	276	1	0	0	0	0	0	0	0	1	13495	1770	62	4		4	RNF43	17	56492699	Silent	SNP	T	TCGA-76-6660-01A-11D-1845-08	8057100	56492699	24702511	84	19907											
DDX5	1655	broad.mit.edu	37	chr17	62502217	62502217	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	cggtcccggccgcggtctcgGtcactcgaataacccgacat	11	16	2	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr17:62502217G>C	uc002jek.2	-	1	268	c.21C>G	c.(19-21)GAC>GAG	p.D7E	CCDC45_uc002jem.2_5'Flank|CCDC45_uc002jen.2_5'Flank|CCDC45_uc010wqb.1_5'Flank|DDX5_uc010deh.2_5'Flank|DDX5_uc002jej.2_5'UTR|DDX5_uc010wqa.1_Missense_Mutation_p.D7E|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	7					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			CGCGGTCTCGGTCACTCGAAT	0.657			T	ETV4	prostate								C	62502217	C	C	62502217	3	2	276	1	0	0	0	0	1	0	0	0	4367	1252	44	5	1875	5	DDX5	17	62502217	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	6009518	62502217	18692993	85	19908											
LAMA1	284217	broad.mit.edu	37	chr18	6956660	6956660	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagcccggggctctggcaagAgcttgctgtcctctgcatcg	13	13	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr18:6956660A>T	uc002knm.2	-	56	8163	c.8069T>A	c.(8068-8070)CTC>CAC	p.L2690H	LAMA1_uc002knk.2_5'Flank|LAMA1_uc002knl.2_Missense_Mutation_p.L143H|LAMA1_uc010wzj.1_Missense_Mutation_p.L2166H	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2690					axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCTGGCAAGAGCTTGCTGTC	0.552													T	6956660	T	T	6956660	3	4	276	1	0	0	0	0	1	0	0	0	8605	304	11	5	1190	5	LAMA1	18	6956660	Missense_Mutation	SNP	A	TCGA-76-6660-01A-11D-1845-08		6956660	71120588	86	19909											
RIT2	6014	broad.mit.edu	37	chr18	40554049	40554049	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	catcacctacctggccagcaGtgtccaagatgtccaagtaa	8	13	1	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr18:40554049G>T	uc002lav.2	-	3	397	c.224C>A	c.(223-225)ACT>AAT	p.T75N	RIT2_uc010dnf.2_Missense_Mutation_p.T75N	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	75	GTP (By similarity).				nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						CTGGCCAGCAGTGTCCAAGAT	0.368													T	40554049	T	T	40554049	3	4	276	1	0	0	0	0	1	0	0	0	13387	1029	36	5	441	5	RIT2	18	40554049	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	33597389	40554049	37523199	87	19910											
BCL2	596	broad.mit.edu	37	chr18	60795928	60795929	+	Frame_Shift_Del	DEL	AG	-	-													ccaaactgagcagagtcttcAgagacagccaggagaaatca							TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr18:60795928_60795929delAG	uc002lit.1	-	3	1142_1143	c.649_650delCT	c.(649-651)CTGfs	p.L217fs	BCL2_uc002liu.1_Frame_Shift_Del_p.L217fs	NM_000633	NP_000624	P10415	BCL2_HUMAN	B-cell lymphoma protein 2 alpha isoform	217	Helical; (Potential).				activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)	1		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	CAGAGTCTTCAGAGACAGCCAG	0.545			T	IGH@	NHL|CLL								-	60795929	-	-	60795928	7	5	276	1	0	1	0	1	0	0	0	0	1365	188	7	0	73	0	BCL2	18	60795928	Frame_Shift_Del	DEL	AG	TCGA-76-6660-01A-11D-1845-08	20241879	60795928	17281320	88	19911											
DNM2	1785	broad.mit.edu	37	chr19	10886491	10886491	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcctgcagttcatcagccgGgagagcagcctcattctggc	11	13	4	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr19:10886491G>A	uc002mps.1	+	4	662	c.498G>A	c.(496-498)CGG>CGA	p.R166R	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.R166R|DNM2_uc002mpv.1_Silent_p.R166R|DNM2_uc002mpu.1_Silent_p.R166R|DNM2_uc010dxl.1_Silent_p.R166R	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	166					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TCATCAGCCGGGAGAGCAGCC	0.607													A	10886491	A	A	10886491	2	1	276	1	0	0	0	0	0	0	0	1	4672	1219	43	3		3	DNM2	19	10886491	Silent	SNP	G	TCGA-76-6660-01A-11D-1845-08		10886491	48242492	89	19912											
RGL3	57139	broad.mit.edu	37	chr19	11526753	11526753	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ttcggacactgcccaggtccGaatgggcaggggggtctcgg	17	11	1	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr19:11526753G>A	uc002mrp.2	-	5	561	c.497C>T	c.(496-498)TCG>TTG	p.S166L	RGL3_uc002mrn.2_5'UTR|RGL3_uc002mrm.2_5'UTR|RGL3_uc002mro.2_Missense_Mutation_p.S166L	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	166	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						GCCCAGGTCCGAATGGGCAGG	0.617													A	11526753	A	A	11526753	3	1	276	1	0	0	0	0	1	0	0	0	13278	1059	37	2	1713	2	RGL3	19	11526753	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	640262	11526753	47602230	90	19913											
ZNF433	163059	broad.mit.edu	37	chr19	12126556	12126556	+	Frame_Shift_Del	DEL	A	-	-													ttgaagtgaactgggagaatAaaaggctttcccacatatct							TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr19:12126556delA	uc002msy.1	-	4	1297	c.1126delT	c.(1126-1128)TATfs	p.Y376fs	uc002msx.1_Intron|ZNF433_uc002msz.1_Frame_Shift_Del_p.Y341fs	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	376	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGGGAGAATAAAAGGCTTTC	0.373													-	12126556	-	-	12126556	7	5	276	1	0	1	0	1	0	0	0	0	17904	362	13	0	899	0	ZNF433	19	12126556	Frame_Shift_Del	DEL	A	TCGA-76-6660-01A-11D-1845-08	599803	12126556	47002427	91	19914											
PEG3	5178	broad.mit.edu	37	chr19	57325278	57325278	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	tgctggaagtgaaggtttctGtgcattcatggcagtcatag	13	6	3	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr19:57325278G>C	uc002qnu.2	-	7	4883	c.4532C>G	c.(4531-4533)ACA>AGA	p.T1511R	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.T1482R|PEG3_uc002qnv.2_Missense_Mutation_p.T1511R|PEG3_uc002qnw.2_Missense_Mutation_p.T1387R|PEG3_uc002qnx.2_Missense_Mutation_p.T1385R|PEG3_uc010etr.2_Missense_Mutation_p.T1511R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1511	Glu-rich.|C2H2-type 11.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GAAGGTTTCTGTGCATTCATG	0.483													C	57325278	C	C	57325278	3	2	276	1	0	0	0	0	1	0	0	0	11720	1377	48	5	238	5	PEG3	19	57325278	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08	45198722	57325278	1803705	92	19915											
PTPRA	5786	broad.mit.edu	37	chr20	3002794	3002794	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtgccttttaccccgatcgGcatgctcaagttcctcaaga	9	13	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr20:3002794G>A	uc010zqd.1	+	14	1606	c.1289G>A	c.(1288-1290)GGC>GAC	p.G430D	PTPRA_uc002whj.2_Missense_Mutation_p.G419D|PTPRA_uc002whk.2_Missense_Mutation_p.G410D|PTPRA_uc002whl.2_Missense_Mutation_p.G410D|PTPRA_uc002whm.2_Missense_Mutation_p.G186D|PTPRA_uc002whn.2_Missense_Mutation_p.G410D|PTPRA_uc002who.2_Missense_Mutation_p.G82D	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	419	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						ACCCCGATCGGCATGCTCAAG	0.572													A	3002794	A	A	3002794	3	1	276	1	0	0	0	0	1	0	0	0	12795	1203	42	3	1302	3	PTPRA	20	3002794	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08		3002794	60022726	93	19916											
RIN2	54453	broad.mit.edu	37	chr20	19981289	19981289	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gttgcatttcaggaggtcaaCagtggttgcacaggaaagac	13	7	2	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr20:19981289C>T	uc002wro.1	+	11	2433	c.2397C>T	c.(2395-2397)AAC>AAT	p.N799N	RIN2_uc010gcu.1_Silent_p.N366N|RIN2_uc010gcv.1_Silent_p.N593N	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	799	Ras-associating.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						AGGAGGTCAACAGTGGTTGCA	0.507													T	19981289	T	T	19981289	2	4	276	1	0	0	0	0	0	0	0	1	13372	477	17	3		3	RIN2	20	19981289	Silent	SNP	C	TCGA-76-6660-01A-11D-1845-08	16978495	19981289	43044231	94	19917											
AURKA	6790	broad.mit.edu	37	chr20	54963223	54963223	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcaatttaccttaacaggtcCtgaaatgcagttttctttag	6	8	2	1	rs6069717		TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr20:54963223C>T	uc002xxd.1	-	4	597	c.31G>A	c.(31-33)GGA>AGA	p.G11R	AURKA_uc002xxe.1_Missense_Mutation_p.G11R|AURKA_uc002xxf.1_Missense_Mutation_p.G11R|AURKA_uc002xxg.1_Missense_Mutation_p.G11R|AURKA_uc002xxh.1_Missense_Mutation_p.G11R|AURKA_uc002xxi.1_Missense_Mutation_p.G11R|AURKA_uc002xxj.1_Missense_Mutation_p.G11R|AURKA_uc002xxk.1_Missense_Mutation_p.G11R|AURKA_uc010zzd.1_RNA	NM_198433	NP_940835	O14965	AURKA_HUMAN	serine/threonine protein kinase 6	11					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(1)|large_intestine(1)|skin(1)	8			Colorectal(105;0.202)			TTAACAGGTCCTGAAATGCAG	0.383													T	54963223	T	T	54963223	3	4	276	1	0	0	0	0	1	0	0	0	1221	690	24	3	1212	3	AURKA	20	54963223	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08	34981934	54963223	8062297	95	19918											
MORC3	23515	broad.mit.edu	37	chr21	37732374	37732374	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ataaccctgacccacagttcAggtaccatagagttggtagt	9	10	1	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr21:37732374A>G	uc002yvi.2	+	11	1406	c.1330A>G	c.(1330-1332)AGA>GGA	p.R444G		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	444	CW-type.				cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						CCCACAGTTCAGGTACCATAG	0.433													G	37732374	G	G	37732374	3	3	276	1	0	0	0	0	1	0	0	0	9703	202	7	4	1372	4	MORC3	21	37732374	Missense_Mutation	SNP	A	TCGA-76-6660-01A-11D-1845-08		37732374	10397521	96	19919											
SH3BGR	6450	broad.mit.edu	37	chr21	40883645	40883645	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gagggtgcggaaggggaagcCgaggaggaggaagaaactgc	21	5	0	1			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr21:40883645C>T	uc002yya.2	+	6	717	c.663C>T	c.(661-663)GCC>GCT	p.A221A	SH3BGR_uc002yxz.2_Silent_p.A110A	NM_007341	NP_031367	P55822	SH3BG_HUMAN	SH3-binding domain and glutamic acid-rich	221	Glu-rich (acidic).				protein complex assembly	cytosol	SH3 domain binding|SH3/SH2 adaptor activity				0		all_cancers(19;1.16e-23)|all_epithelial(19;1.22e-20)|Prostate(19;2.55e-06)|Breast(209;0.0133)		STAD - Stomach adenocarcinoma(101;0.00151)		AAGGGGAAGCCGAGGAGGAGG	0.448													T	40883645	T	T	40883645	2	4	276	1	0	0	0	0	0	0	0	1	14240	639	23	2		2	SH3BGR	21	40883645	Silent	SNP	C	TCGA-76-6660-01A-11D-1845-08	3151271	40883645	7246250	97	19920											
TPST2	8459	broad.mit.edu	37	chr22	26937392	26937392	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccacccacgaagatgagcgGcatggccttgccatagcggt	13	13	0	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chr22:26937392G>A	uc003acv.2	-	2	373	c.205C>T	c.(205-207)CCG>TCG	p.P69S	TPST2_uc003acw.2_Missense_Mutation_p.P69S|TPST2_uc003acx.2_Missense_Mutation_p.P69S|TPST2_uc011akf.1_Missense_Mutation_p.P69S	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	69	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						AAGATGAGCGGCATGGCCTTG	0.701													A	26937392	A	A	26937392	3	1	276	1	0	0	0	0	1	0	0	0	16425	1203	42	3	944	3	TPST2	22	26937392	Missense_Mutation	SNP	G	TCGA-76-6660-01A-11D-1845-08		26937392	24367174	98	19921											
WWC3	55841	broad.mit.edu	37	chrX	10058926	10058926	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacaggcgagaaggagaggCgggacctgatgcatgtaagc	17	8	0	3			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chrX:10058926C>T	uc004csx.3	+	6	691	c.493C>T	c.(493-495)CGG>TGG	p.R165W	WWC3_uc010nds.2_5'UTR|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	165										ovary(4)	4						GAAGGAGAGGCGGGACCTGAT	0.423													T	10058926	T	T	10058926	3	4	276	1	0	0	0	0	1	0	0	0	17410	759	27	1	511	1	WWC3	23	10058926	Missense_Mutation	SNP	C	TCGA-76-6660-01A-11D-1845-08		10058926	145211634	99	19922											
IGSF1	3547	broad.mit.edu	37	chrX	130409145	130409145	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aaaggctcctgagccccctcCttcaacaggacaaatgttga	8	13	1	2			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chrX:130409145C>T	uc004ewd.2	-	17	3538	c.3300G>A	c.(3298-3300)AAG>AAA	p.K1100K	IGSF1_uc004ewe.3_Silent_p.K1094K|IGSF1_uc004ewf.2_Silent_p.K1080K	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1100	Extracellular (Potential).|Ig-like C2-type 11.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GAGCCCCCTCCTTCAACAGGA	0.547													T	130409145	T	T	130409145	2	4	276	1	0	0	0	0	0	0	0	1	7596	680	24	3		3	IGSF1	23	130409145	Silent	SNP	C	TCGA-76-6660-01A-11D-1845-08	120350219	130409145	24861415	100	19923											
MAGEC1	9947	broad.mit.edu	37	chrX	140995944	140995944	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gtggacgagttggcgcggttTcttctcctcaaatatcaagt	11	9	4	0			TCGA-76-6660-01A-11D-1845-08	TCGA-76-6660-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	f4960945-c464-49c2-8ad6-d73a6fa47b20	59562be7-e77a-4b64-b286-5980b286641a	g.chrX:140995944T>C	uc004fbt.2	+	4	3040	c.2754T>C	c.(2752-2754)TTT>TTC	p.F918F	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	918	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TGGCGCGGTTTCTTCTCCTCA	0.483										HNSCC(15;0.026)			C	140995944	C	C	140995944	2	2	276	1	0	0	0	0	0	0	0	1	9180	1780	62	4		4	MAGEC1	23	140995944	Silent	SNP	T	TCGA-76-6660-01A-11D-1845-08	10586799	140995944	14274616	101	19924											
OXCT2	64064	broad.mit.edu	37	chr1	40235523	40235523	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cacgtcaaacacggccttctCggtgatgatgcggtccacgc	11	14	2	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr1:40235523C>T	uc001ceb.1	-	1	1498	c.1405G>A	c.(1405-1407)GAG>AAG	p.E469K	BMP8B_uc001cdz.1_Intron|BMP8B_uc001cea.1_Intron|OXCT2_uc009vvu.1_Missense_Mutation_p.E463K	NM_022120	NP_071403	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2 precursor	469					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			pancreas(1)	1	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	ACGGCCTTCTCGGTGATGATG	0.592													T	40235523	T	T	40235523	3	4	277	1	0	0	0	0	1	0	0	0	11330	893	31	2	152	2	OXCT2	1	40235523	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08		40235523	209015098	1	19925											
DMRTB1	63948	broad.mit.edu	37	chr1	53930361	53930361	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctactacctgccgccgccgCcgccgccactgccgcccctt	9	23	0	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr1:53930361C>T	uc001cvq.1	+	3	857	c.802C>T	c.(802-804)CCG>TCG	p.P268S		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	268	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						gccgccgccgccgccgccact	0.557													T	53930361	T	T	53930361	3	4	277	1	0	0	0	0	1	0	0	0	4590	739	26	3	812	3	DMRTB1	1	53930361	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	13694838	53930361	195320260	2	19926											
SELE	6401	broad.mit.edu	37	chr1	169698648	169698648	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctttacacgttggcttctcGttgtcccaattcccagatga	7	13	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr1:169698648G>A	uc001ggm.3	-	6	1039	c.882C>T	c.(880-882)AAC>AAT	p.N294N	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	294	Sushi 2.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					TTGGCTTCTCGTTGTCCCAAT	0.458													A	169698648	A	A	169698648	2	1	277	1	0	0	0	0	0	0	0	1	14013	1136	40	1		1	SELE	1	169698648	Silent	SNP	G	TCGA-76-6661-01B-11D-1845-08	115768287	169698648	79551973	3	19927											
USH2A	7399	broad.mit.edu	37	chr1	215931985	215931985	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ataaggcccaattactgtgaTattatatggaggatagattt	9	4	0	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr1:215931985T>C	uc001hku.1	-	58	11728	c.11341A>G	c.(11341-11343)ATC>GTC	p.I3781V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3781	Fibronectin type-III 23.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTACTGTGATATTATATGGA	0.353										HNSCC(13;0.011)			C	215931985	C	C	215931985	3	2	277	1	0	0	0	0	1	0	0	0	17033	1406	49	4	4327	4	USH2A	1	215931985	Missense_Mutation	SNP	T	TCGA-76-6661-01B-11D-1845-08	46233337	215931985	33318636	4	19928											
OR2T4	127074	broad.mit.edu	37	chr1	248525822	248525822	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctgtcttctataccatcctcActccagtggtgaacccttta	5	14	3	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr1:248525822A>T	uc001ieh.1	+	1	940	c.940A>T	c.(940-942)ACT>TCT	p.T314S		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	314	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TACCATCCTCACTCCAGTGGT	0.463													T	248525822	T	T	248525822	3	4	277	1	0	0	0	0	1	0	0	0	11027	159	6	5	942	5	OR2T4	1	248525822	Missense_Mutation	SNP	A	TCGA-76-6661-01B-11D-1845-08	32593837	248525822	724799	5	19929											
MERTK	10461	broad.mit.edu	37	chr2	112785992	112785992	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gccccaccttttcagtattgAggctgcagctagaaaaactc	8	12	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr2:112785992A>G	uc002thk.1	+	19	2673	c.2551A>G	c.(2551-2553)AGG>GGG	p.R851G	MERTK_uc002thl.1_Missense_Mutation_p.R675G	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	851	Protein kinase.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TTCAGTATTGAGGCTGCAGCT	0.453													G	112785992	G	G	112785992	3	3	277	1	0	0	0	0	1	0	0	0	9479	295	11	4	2625	4	MERTK	2	112785992	Missense_Mutation	SNP	A	TCGA-76-6661-01B-11D-1845-08		112785992	130413381	6	19930											
TTN	7273	broad.mit.edu	37	chr2	179594237	179594237	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aacttcacactccagctccaCgtcactatattttactacct	2	15	2	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr2:179594237C>T	uc010zfg.1	-	61	15138	c.14914G>A	c.(14914-14916)GTG>ATG	p.V4972M	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V1633M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5899							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGCTCCACGTCACTATAT	0.448													T	179594237	T	T	179594237	3	4	277	1	0	0	0	0	1	0	0	0	16732	536	19	1	86079	1	TTN	2	179594237	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	66808245	179594237	63605136	7	19931											
PIKFYVE	200576	broad.mit.edu	37	chr2	209153464	209153464	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctttatagtttgattcatcCagattcctcaaatactcctc	3	11	3	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr2:209153464C>T	uc002vcz.2	+	7	991	c.833C>T	c.(832-834)CCA>CTA	p.P278L	PIKFYVE_uc010fun.1_5'UTR|PIKFYVE_uc002vcy.1_Missense_Mutation_p.P278L|PIKFYVE_uc002vcv.2_Missense_Mutation_p.P181L|PIKFYVE_uc002vcw.2_Missense_Mutation_p.P278L|PIKFYVE_uc002vcx.2_Missense_Mutation_p.P192L	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	278					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TTGATTCATCCAGATTCCTCA	0.343													T	209153464	T	T	209153464	3	4	277	1	0	0	0	0	1	0	0	0	11924	594	21	3	855	3	PIKFYVE	2	209153464	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	29559227	209153464	34045909	8	19932											
COL4A4	1286	broad.mit.edu	37	chr2	227942664	227942664	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acctgggtggcctggaactcCtgggtggcctcgctctcctg	14	14	1	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr2:227942664C>T	uc010zlt.1	-	25	2587	c.1933G>A	c.(1933-1935)GGA>AGA	p.G645R		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	645	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTGGAACTCCTGGGTGGCCT	0.493													T	227942664	T	T	227942664	3	4	277	1	0	0	0	0	1	0	0	0	3693	690	24	3	3235	3	COL4A4	2	227942664	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	18789200	227942664	15256709	9	19933			1	47		3	3	36	C		2.704413e-09
COL4A4	1286	broad.mit.edu	37	chr2	227942679	227942679	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	aactcctgggtggcctcgctCtcctggtggaccaggaaatc	12	13	1	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr2:227942679C>T	uc010zlt.1	-	25	2572	c.1918G>A	c.(1918-1920)GAG>AAG	p.E640K		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	640	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGGCCTCGCTCTCCTGGTGGA	0.547													T	227942679	T	T	227942679	3	4	277	1	0	0	0	0	1	0	0	0	3693	922	32	3	3250	3	COL4A4	2	227942679	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	15	227942679	15256694	10	19934			1	47		3	3	36	C		2.704413e-09
COL4A4	1286	broad.mit.edu	37	chr2	227942699	227942699	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctcctggtggaccaggaaatCccagtcctgggggccccaca	12	15	0	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr2:227942699C>T	uc010zlt.1	-	25	2552	c.1898G>A	c.(1897-1899)GGA>GAA	p.G633E		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	633	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ACCAGGAAATCCCAGTCCTGG	0.602													T	227942699	T	T	227942699	3	4	277	1	0	0	0	0	1	0	0	0	3693	855	30	3	3270	3	COL4A4	2	227942699	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	20	227942699	15256674	11	19935			1	47		3	3	36	C		2.704413e-09
LAMP3	27074	broad.mit.edu	37	chr3	182871533	182871533	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttatacagagtctgcttccGtttagaacctgataaattcc	6	9	1	3	rs140803277	by1000genomes	TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr3:182871533G>A	uc003flh.3	-	2	920	c.696C>T	c.(694-696)AAC>AAT	p.N232N		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	232	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			GTCTGCTTCCGTTTAGAACCT	0.502													A	182871533	A	A	182871533	2	1	277	1	0	0	0	0	0	0	0	1	8619	1136	40	1		1	LAMP3	3	182871533	Silent	SNP	G	TCGA-76-6661-01B-11D-1845-08		182871533	15150897	12	19936											
EPHB3	2049	broad.mit.edu	37	chr3	184295702	184295702	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccaggctctggggcccagcaGctccaggagcagcttcccct	12	17	1	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr3:184295702G>A	uc003foz.2	+	8	2093	c.1656G>A	c.(1654-1656)CAG>CAA	p.Q552Q		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	552	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GGGCCCAGCAGCTCCAGGAGC	0.637													A	184295702	A	A	184295702	2	1	277	1	0	0	0	0	0	0	0	1	5176	962	34	3		3	EPHB3	3	184295702	Silent	SNP	G	TCGA-76-6661-01B-11D-1845-08	1424169	184295702	13726728	13	19937											
C3orf70	285382	broad.mit.edu	37	chr3	184870498	184870498	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcacagatagacagcccgtcGcacggctggaagtcgggtct	14	12	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr3:184870498G>A	uc003fpd.2	-	1	305	c.114C>T	c.(112-114)TGC>TGT	p.C38C		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	38											0						ACAGCCCGTCGCACGGCTGGA	0.642													A	184870498	A	A	184870498	2	1	277	1	0	0	0	0	0	0	0	1	2242	1079	38	1		1	C3orf70	3	184870498	Silent	SNP	G	TCGA-76-6661-01B-11D-1845-08	574796	184870498	13151932	14	19938											
LIAS	11019	broad.mit.edu	37	chr4	39462478	39462478	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ccagataaaaaaaaggaactCctacagaatggaccagacct	7	10	0	3			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr4:39462478C>A	uc003guf.2	+	2	187	c.114C>A	c.(112-114)CTC>CTA	p.L38L	RPL9_uc003gub.2_5'Flank|RPL9_uc003guc.2_5'Flank|RPL9_uc011byk.1_5'Flank|RPL9_uc011byl.1_5'Flank|RPL9_uc003gud.1_5'Flank|LIAS_uc003gue.3_Silent_p.L38L|LIAS_uc011bym.1_Silent_p.L38L|LIAS_uc003gug.2_Silent_p.L38L|LIAS_uc003guh.2_Silent_p.L38L	NM_006859	NP_006850	O43766	LIAS_HUMAN	lipoic acid synthetase isoform 1 precursor	38					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding				0					Lipoic Acid(DB00166)	AAAAGGAACTCCTACAGAATG	0.398													A	39462478	A	A	39462478	2	1	277	1	0	0	0	0	0	0	0	1	8778	842	30	5		5	LIAS	4	39462478	Silent	SNP	C	TCGA-76-6661-01B-11D-1845-08		39462478	151691798	15	19939											
FBN2	2201	broad.mit.edu	37	chr5	127674667	127674667	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gaagccactttcatagccttCgaagcactcgcactcaaagc	7	14	2	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr5:127674667C>A	uc003kuu.2	-	26	3869	c.3430G>T	c.(3430-3432)GAA>TAA	p.E1144*	FBN2_uc003kuv.2_Nonsense_Mutation_p.E1111*	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1144	EGF-like 16; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCATAGCCTTCGAAGCACTCG	0.507													A	127674667	A	A	127674667	4	1	277	1	0	0	0	0	0	1	0	0	5703	893	31	5	5468	5	FBN2	5	127674667	Nonsense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08		127674667	53240593	16	19940											
ADAMTS19	171019	broad.mit.edu	37	chr5	128862027	128862027	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaaagtggaagagggaaaCgatattcatacaaattacct	9	6	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr5:128862027C>T	uc003kvb.1	+	4	946	c.946C>T	c.(946-948)CGA>TGA	p.R316*	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	316					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AAGAGGGAAACGATATTCATA	0.398													T	128862027	T	T	128862027	4	4	277	1	0	0	0	0	0	1	0	0	264	528	19	1	960	1	ADAMTS19	5	128862027	Nonsense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	1187360	128862027	52053233	17	19941											
PCDHA5	56143	broad.mit.edu	37	chr5	140203028	140203028	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcaggtgttcgtgctggaCgagaacgacaacgcgccggc	15	12	0	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr5:140203028C>T	uc003lhl.2	+	1	1668	c.1668C>T	c.(1666-1668)GAC>GAT	p.D556D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.D556D|PCDHA5_uc003lhj.1_Silent_p.D556D	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	556	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTGCTGGACGAGAACGACA	0.706													T	140203028	T	T	140203028	2	4	277	1	0	0	0	0	0	0	0	1	11527	535	19	1		1	PCDHA5	5	140203028	Silent	SNP	C	TCGA-76-6661-01B-11D-1845-08	11341001	140203028	40712232	18	19942											
PCDHB5	26167	broad.mit.edu	37	chr5	140515027	140515027	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggtctgaacaatggagactgCgctagcaaaaacgccacaga	11	10	1	3			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr5:140515027C>T	uc003liq.2	+	1	228	c.11C>T	c.(10-12)GCG>GTG	p.A4V		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	4					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGGAGACTGCGCTAGCAAAA	0.458													T	140515027	T	T	140515027	3	4	277	1	0	0	0	0	1	0	0	0	11545	768	27	1	13	1	PCDHB5	5	140515027	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	311999	140515027	40400233	19	19943											
DDX41	51428	broad.mit.edu	37	chr5	176941751	176941751	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ggacatgcccccaatgcagaGggcgcagcgcaggagtggtg	17	11	0	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr5:176941751G>C	uc003mho.2	-	9	907	c.886C>G	c.(886-888)CTC>GTC	p.L296V	DDX41_uc003mhm.2_Missense_Mutation_p.L76V|DDX41_uc003mhn.2_Missense_Mutation_p.L165V|DDX41_uc003mhp.2_Missense_Mutation_p.L165V|DDX41_uc003mhq.1_Missense_Mutation_p.L76V	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	296	Helicase ATP-binding.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			CCAATGCAGAGGGCGCAGCGC	0.662													C	176941751	C	C	176941751	3	2	277	1	0	0	0	0	1	0	0	0	4361	1000	35	5	1018	5	DDX41	5	176941751	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08	36426724	176941751	3973509	20	19944											
MAML1	9794	broad.mit.edu	37	chr5	179201198	179201198	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agaccaacgtgggccagaacAcctccgtctcagctgcctat	9	15	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr5:179201198A>C	uc003mkm.2	+	5	2634	c.2371A>C	c.(2371-2373)ACC>CCC	p.T791P	MAML1_uc003mkn.1_Intron	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	791					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGCCAGAACACCTCCGTCTC	0.592													C	179201198	C	C	179201198	3	2	277	1	0	0	0	0	1	0	0	0	9205	159	6	5	2389	5	MAML1	5	179201198	Missense_Mutation	SNP	A	TCGA-76-6661-01B-11D-1845-08	2259447	179201198	1714062	21	19945											
GTF3C6	112495	broad.mit.edu	37	chr6	111288823	111288823	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	aagtggtagcttcagccccaGataaatctttggaattggaa	10	7	2	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr6:111288823G>T	uc003pum.2	+	6	682	c.472G>T	c.(472-474)GAT>TAT	p.D158Y		NM_138408	NP_612417	Q969F1	TF3C6_HUMAN	general transcription factor IIIC, polypeptide	158						transcription factor TFIIIC complex	DNA binding|protein binding				0		all_cancers(87;0.00328)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|Colorectal(196;0.0466)|all_epithelial(87;0.0575)		OV - Ovarian serous cystadenocarcinoma(136;0.105)|all cancers(137;0.179)|Epithelial(106;0.186)		TTCAGCCCCAGATAAATCTTT	0.383													T	111288823	T	T	111288823	3	4	277	1	0	0	0	0	1	0	0	0	6877	942	33	5	494	5	GTF3C6	6	111288823	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08		111288823	59826244	22	19946											
NMBR	4829	broad.mit.edu	37	chr6	142409496	142409496	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgaagaagtagcgcgaggcGtccaccgggacgcaggtgag	17	10	0	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr6:142409496G>A	uc003qiu.2	-	1	441	c.300C>T	c.(298-300)GAC>GAT	p.D100D		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	100	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		AGCGCGAGGCGTCCACCGGGA	0.592													A	142409496	A	A	142409496	2	1	277	1	0	0	0	0	0	0	0	1	10487	1136	40	1		1	NMBR	6	142409496	Silent	SNP	G	TCGA-76-6661-01B-11D-1845-08	31120673	142409496	28705571	23	19947											
HECW1	23072	broad.mit.edu	37	chr7	43351508	43351508	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacctcaggggcggcccccaCgatggcgtcaccattccccg	12	18	2	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr7:43351508C>T	uc003tid.1	+	4	779	c.174C>T	c.(172-174)CAC>CAT	p.H58H	HECW1_uc011kbi.1_Silent_p.H58H|HECW1_uc003tie.1_Silent_p.H90H	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	58					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GCGGCCCCCACGATGGCGTCA	0.632													T	43351508	T	T	43351508	2	4	277	1	0	0	0	0	0	0	0	1	7042	535	19	1		1	HECW1	7	43351508	Silent	SNP	C	TCGA-76-6661-01B-11D-1845-08		43351508	115787155	24	19948											
EGFR	1956	broad.mit.edu	37	chr7	55223543	55223543	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gtaattatgtggtgacagatCacggctcgtgcgtccgagcc	13	10	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr7:55223543C>T	uc003tqk.2	+	8	1156	c.910C>T	c.(910-912)CAC>TAC	p.H304Y	EGFR_uc003tqh.2_Missense_Mutation_p.H304Y|EGFR_uc003tqi.2_Missense_Mutation_p.H304Y|EGFR_uc003tqj.2_Missense_Mutation_p.H304Y|EGFR_uc010kzg.1_Missense_Mutation_p.H259Y|EGFR_uc011kco.1_Missense_Mutation_p.H251Y|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	304	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGTGACAGATCACGGCTCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55223543	T	T	55223543	3	4	277	1	0	0	0	0	1	0	0	0	4967	826	29	3	940	3	EGFR	7	55223543	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	11872035	55223543	103915120	25	19949											
FZD9	8326	broad.mit.edu	37	chr7	72849307	72849307	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctactgctctactacttcGgcatggccagctcgctctgg	9	15	2	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr7:72849307G>A	uc003tyb.2	+	1	1199	c.970G>A	c.(970-972)GGC>AGC	p.G324S		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	324	Helical; Name=3; (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				CTACTACTTCGGCATGGCCAG	0.657													A	72849307	A	A	72849307	3	1	277	1	0	0	0	0	1	0	0	0	6137	1116	39	2	972	2	FZD9	7	72849307	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08	17625764	72849307	86289356	26	19950											
SEMA3E	9723	broad.mit.edu	37	chr7	82997104	82997104	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gctgcaagaattccttgtacCatggttttgctccctgcgag	10	11	0	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr7:82997104C>A	uc003uhy.1	-	17	2592	c.2126G>T	c.(2125-2127)TGG>TTG	p.W709L		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	709					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TTCCTTGTACCATGGTTTTGC	0.463													A	82997104	A	A	82997104	3	1	277	1	0	0	0	0	1	0	0	0	14028	595	21	5	205	5	SEMA3E	7	82997104	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	10147797	82997104	76141559	27	19951											
CYP3A5	1577	broad.mit.edu	37	chr7	99261679	99261679	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttttggaaacagagagacaTttaatgcttcaaaaactggg	9	6	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr7:99261679T>G	uc003urq.2	-	8	797	c.710A>C	c.(709-711)AAT>ACT	p.N237T	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Missense_Mutation_p.N57T|CYP3A5_uc003urr.2_Missense_Mutation_p.N124T|CYP3A5_uc011kiy.1_Missense_Mutation_p.N227T|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	237					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	CAGAGAGACATTTAATGCTTC	0.328													G	99261679	G	G	99261679	3	3	277	1	0	0	0	0	1	0	0	0	4180	1493	52	5	822	5	CYP3A5	7	99261679	Missense_Mutation	SNP	T	TCGA-76-6661-01B-11D-1845-08	16264575	99261679	59876984	28	19952											
ASZ1	136991	broad.mit.edu	37	chr7	117067470	117067470	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcctcgctctcgctactctcGcctccgccagccactggcag	8	20	2	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr7:117067470G>A	uc003vjb.2	-	1	108	c.45C>T	c.(43-45)GGC>GGT	p.G15G	ASZ1_uc011kno.1_Silent_p.G15G|ASZ1_uc011knp.1_5'UTR	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	15					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CGCTACTCTCGCCTCCGCCAG	0.662											OREG0003439	type=REGULATORY REGION|Gene=ASZ1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	A	117067470	A	A	117067470	2	1	277	1	0	0	0	0	0	0	0	1	1069	1074	38	1		1	ASZ1	7	117067470	Silent	SNP	G	TCGA-76-6661-01B-11D-1845-08	17805791	117067470	42071193	29	19953											
CHPF2	54480	broad.mit.edu	37	chr7	150934492	150934492	+	Silent	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aacctgaccgtgctgaccccCgaaggggaggcagggctgag	16	12	0	3			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr7:150934492C>G	uc003wjr.1	+	4	2557	c.1044C>G	c.(1042-1044)CCC>CCG	p.P348P	CHPF2_uc003wjq.1_Silent_p.P340P|MIR671_hsa-mir-671|MI0003760_5'Flank	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	348	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						TGCTGACCCCCGAAGGGGAGG	0.602													G	150934492	G	G	150934492	2	3	277	1	0	0	0	0	0	0	0	1	3369	639	23	5		5	CHPF2	7	150934492	Silent	SNP	C	TCGA-76-6661-01B-11D-1845-08	33867022	150934492	8204171	30	19954											
RP1L1	94137	broad.mit.edu	37	chr8	10469501	10469501	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgatgagcttccagaatatcGtggcactgagccatcctggc	11	12	0	3			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr8:10469501G>A	uc003wtc.2	-	4	2336	c.2107C>T	c.(2107-2109)CGA>TGA	p.R703*		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	703					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCAGAATATCGTGGCACTGAG	0.617													A	10469501	A	A	10469501	4	1	277	1	0	0	0	0	0	1	0	0	13533	1153	40	1	5099	1	RP1L1	8	10469501	Nonsense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08		10469501	135894521	31	19955											
BLK	640	broad.mit.edu	37	chr8	11406564	11406564	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtggctggccaggtcactcGtcacaggaagagaaggctat	15	9	2	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr8:11406564G>A	uc003wty.2	+	5	882	c.301G>A	c.(301-303)GTC>ATC	p.V101I	BLK_uc003wtz.2_Missense_Mutation_p.V30I	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	101	SH3.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CAGGTCACTCGTCACAGGAAG	0.592													A	11406564	A	A	11406564	3	1	277	1	0	0	0	0	1	0	0	0	1444	1145	40	1	315	1	BLK	8	11406564	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08	937063	11406564	134957458	32	19956											
SPATC1	375686	broad.mit.edu	37	chr8	145095802	145095802	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgccccccatcccccttcccGaatgcataattccccaaccc	3	22	0	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr8:145095802G>A	uc011lkw.1	+	3	1202	c.1100G>A	c.(1099-1101)CGA>CAA	p.R367Q	SPATC1_uc011lkx.1_Missense_Mutation_p.R367Q	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	367										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCCCTTCCCGAATGCATAAT	0.527													A	145095802	A	A	145095802	3	1	277	1	0	0	0	0	1	0	0	0	15016	1058	37	2	1110	2	SPATC1	8	145095802	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08	133689238	145095802	1268220	33	19957											
PIP5KL1	138429	broad.mit.edu	37	chr9	130689473	130689473	+	Silent	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gggtagaagacgctctgcatGacgatgaagtacgtctgggg	16	7	2	4			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr9:130689473G>A	uc011mao.1	-	7	654	c.609C>T	c.(607-609)GTC>GTT	p.V203V	PIP5KL1_uc004bsu.2_5'UTR	NM_001135219	NP_001128691	Q5T9C9	PI5L1_HUMAN	phosphatidylinositol-4-phosphate 5-kinase-like 1	203	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			lung(1)|kidney(1)	2						CGCTCTGCATGACGATGAAGT	0.697													A	130689473	A	A	130689473	2	1	277	1	0	0	0	0	0	0	0	1	11942	1277	45	3		3	PIP5KL1	9	130689473	Silent	SNP	G	TCGA-76-6661-01B-11D-1845-08		130689473	10523958	34	19958											
GRID1	2894	broad.mit.edu	37	chr10	87628864	87628864	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gattgtcctttgcagacggaAagatttgccggaccacggtc	12	10	0	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr10:87628864A>G	uc001kdl.1	-	6	955	c.854T>C	c.(853-855)TTT>TCT	p.F285S	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	285	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TGCAGACGGAAAGATTTGCCG	0.542										Multiple Myeloma(13;0.14)			G	87628864	G	G	87628864	3	3	277	1	0	0	0	0	1	0	0	0	6771	14	1	4	2219	4	GRID1	10	87628864	Missense_Mutation	SNP	A	TCGA-76-6661-01B-11D-1845-08		87628864	47905883	35	19959											
PTEN	5728	broad.mit.edu	37	chr10	89720664	89720664	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttttaggacaaaatgtttcActtttgggtaaatacattct	6	5	2	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr10:89720664A>C	uc001kfb.2	+	9	1846	c.815A>C	c.(814-816)CAC>CCC	p.H272P		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	272	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.D268_F279>VGQNVSLLGKYI(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.H272Y(1)|p.G165_K342del(1)|p.H272R(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AAAATGTTTCACTTTTGGGTA	0.244		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89720664	C	C	89720664	3	2	277	1	0	0	0	0	1	0	0	0	12738	159	6	5	845	5	PTEN	10	89720664	Missense_Mutation	SNP	A	TCGA-76-6661-01B-11D-1845-08	2091800	89720664	45814083	36	19960											
KCNA4	3739	broad.mit.edu	37	chr11	30033088	30033088	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaactcaaaggaaaaccataCaatacagactgtttccacga	5	10	1	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr11:30033088C>A	uc001msk.2	-	2	2290	c.1138G>T	c.(1138-1140)GTA>TTA	p.V380L		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	380	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GAAAACCATACAATACAGACT	0.433													A	30033088	A	A	30033088	3	1	277	1	0	0	0	0	1	0	0	0	8005	478	17	5	827	5	KCNA4	11	30033088	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08		30033088	104973428	37	19961											
OR5A1	219982	broad.mit.edu	37	chr11	59211187	59211187	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcatcaaccacttcttctgCgacctcccaccagtcctggc	5	18	4	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr11:59211187C>T	uc001nnx.1	+	1	546	c.546C>T	c.(544-546)TGC>TGT	p.C182C		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						ACTTCTTCTGCGACCTCCCAC	0.537													T	59211187	T	T	59211187	2	4	277	1	0	0	0	0	0	0	0	1	11139	776	27	1		1	OR5A1	11	59211187	Silent	SNP	C	TCGA-76-6661-01B-11D-1845-08	29178099	59211187	75795329	38	19962											
TMEM109	79073	broad.mit.edu	37	chr11	60687316	60687316	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	aacagaagagagaagccccaGttgatgtcttgacccagata	10	9	1	6			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr11:60687316G>C	uc001nqg.2	+	2	529	c.151G>C	c.(151-153)GTT>CTT	p.V51L	TMEM109_uc001nqh.2_Missense_Mutation_p.V51L	NM_024092	NP_076997	Q9BVC6	TM109_HUMAN	transmembrane protein 109 precursor	51						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane					0						AGAAGCCCCAGTTGATGTCTT	0.557													C	60687316	C	C	60687316	3	2	277	1	0	0	0	0	1	0	0	0	16022	1029	36	5	153	5	TMEM109	11	60687316	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08	1476129	60687316	74319200	39	19963											
RIN1	9610	broad.mit.edu	37	chr11	66102539	66102539	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggacacgcgcactttgaagCttctcttgaatttctcccgc	8	13	2	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr11:66102539C>T	uc001ohn.1	-	6	858	c.731G>A	c.(730-732)AGC>AAC	p.S244N	RIN1_uc010roy.1_5'UTR|RIN1_uc009yrd.1_5'UTR|RIN1_uc010roz.1_Missense_Mutation_p.S139N|RIN1_uc010rpa.1_Missense_Mutation_p.S139N	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	244					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						CACTTTGAAGCTTCTCTTGAA	0.662													T	66102539	T	T	66102539	3	4	277	1	0	0	0	0	1	0	0	0	13371	797	28	3	1640	3	RIN1	11	66102539	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	5415223	66102539	68903977	40	19964											
NLRX1	79671	broad.mit.edu	37	chr11	119044727	119044727	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acttccggctggcaggcacgGgactttgtagtgacccggag	15	11	0	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr11:119044727G>A	uc001pvu.2	+	5	984	c.769G>A	c.(769-771)GGA>AGA	p.G257R	NLRX1_uc010rzc.1_Missense_Mutation_p.G79R|NLRX1_uc001pvv.2_Missense_Mutation_p.G257R|NLRX1_uc001pvw.2_Missense_Mutation_p.G257R|NLRX1_uc001pvx.2_Missense_Mutation_p.G257R	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	257	Required for interaction with MAVS.|NACHT.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGCAGGCACGGGACTTTGTAG	0.592													A	119044727	A	A	119044727	3	1	277	1	0	0	0	0	1	0	0	0	10485	1233	43	3	783	3	NLRX1	11	119044727	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08	52942188	119044727	15961789	41	19965											
KDM5A	5927	broad.mit.edu	37	chr12	402172	402172	+	Nonsense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctttgatttgtctgcacctAattttaatttcttctttcta	3	9	4	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr12:402172A>C	uc001qif.1	-	27	4982	c.4619T>G	c.(4618-4620)TTA>TGA	p.L1540*	KDM5A_uc001qie.1_Nonsense_Mutation_p.L1545*	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1540	Lys-rich.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						GTCTGCACCTAATTTTAATTT	0.378			T 	NUP98	AML								C	402172	C	C	402172	4	2	277	1	0	0	0	0	0	1	0	0	8133	372	13	5	461	5	KDM5A	12	402172	Nonsense_Mutation	SNP	A	TCGA-76-6661-01B-11D-1845-08		402172	133449723	42	19966											
CD163	9332	broad.mit.edu	37	chr12	7639177	7639177	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tggcactgccaaatgcgggaTtcttttccattgcatttcat	8	10	2	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr12:7639177T>A	uc001qsz.3	-	10	2504	c.2376A>T	c.(2374-2376)GAA>GAT	p.E792D	CD163_uc001qta.3_Missense_Mutation_p.E792D|CD163_uc009zfw.2_Missense_Mutation_p.E825D	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	792	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						AAATGCGGGATTCTTTTCCAT	0.512													A	7639177	A	A	7639177	3	1	277	1	0	0	0	0	1	0	0	0	2967	1490	52	5	1122	5	CD163	12	7639177	Missense_Mutation	SNP	T	TCGA-76-6661-01B-11D-1845-08	7237005	7639177	126212718	43	19967											
HOXC9	3225	broad.mit.edu	37	chr12	54396220	54396220	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttggccctccaggcaaccCcgtggccaactggattcacg	11	15	1	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr12:54396220C>T	uc001sep.2	+	3	643	c.545C>T	c.(544-546)CCC>CTC	p.P182L	HOXC9_uc001seq.2_Missense_Mutation_p.P182L	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	182					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						CCAGGCAACCCCGTGGCCAAC	0.577													T	54396220	T	T	54396220	3	4	277	1	0	0	0	0	1	0	0	0	7317	623	22	3	551	3	HOXC9	12	54396220	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	46757043	54396220	79455675	44	19968											
LRP1	4035	broad.mit.edu	37	chr12	57581220	57581220	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgaccacccacgggccttcGttttggacgagtgccagaag	12	12	0	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr12:57581220G>A	uc001snd.2	+	42	7478	c.7012G>A	c.(7012-7014)GTT>ATT	p.V2338I		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2338	LDL-receptor class B 22.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACGGGCCTTCGTTTTGGACGA	0.622													A	57581220	A	A	57581220	3	1	277	1	0	0	0	0	1	0	0	0	8951	1145	40	1	7178	1	LRP1	12	57581220	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08	3185000	57581220	76270675	45	19969											
SBNO1	55206	broad.mit.edu	37	chr12	123782584	123782584	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctgcatcttcacgtttgtgCcactgacagatgctagaaca	8	11	3	3			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr12:123782584C>T	uc010tap.1	-	30	3980	c.3980G>A	c.(3979-3981)GGC>GAC	p.G1327D	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.G1326D|SBNO1_uc010taq.1_Missense_Mutation_p.G278D	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1327							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CACGTTTGTGCCACTGACAGA	0.428													T	123782584	T	T	123782584	3	4	277	1	0	0	0	0	1	0	0	0	13862	739	26	3	209	3	SBNO1	12	123782584	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	66201364	123782584	10069311	46	19970											
MTHFD1	4522	broad.mit.edu	37	chr14	64882182	64882182	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taacactgaagaagtgatcaAtgctattgcacccgagaagg	10	8	1	4			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr14:64882182A>G	uc001xhb.2	+	5	734	c.347A>G	c.(346-348)AAT>AGT	p.N116S	MTHFD1_uc010aqe.2_Missense_Mutation_p.N152S|MTHFD1_uc010aqf.2_Missense_Mutation_p.N172S	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	116	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GAAGTGATCAATGCTATTGCA	0.383													G	64882182	G	G	64882182	3	3	277	1	0	0	0	0	1	0	0	0	9927	101	4	4	365	4	MTHFD1	14	64882182	Missense_Mutation	SNP	A	TCGA-76-6661-01B-11D-1845-08		64882182	42467358	47	19971											
CCDC88C	440193	broad.mit.edu	37	chr14	91770270	91770270	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtggtggttctgcagcagcGtgtactgcgcggtgagcgct	17	9	1	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr14:91770270G>A	uc010aty.2	-	20	3509	c.3410C>T	c.(3409-3411)ACG>ATG	p.T1137M		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1137					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				CTGCAGCAGCGTGTACTGCGC	0.657													A	91770270	A	A	91770270	3	1	277	1	0	0	0	0	1	0	0	0	2865	1145	40	1	2720	1	CCDC88C	14	91770270	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08	26888088	91770270	15579270	48	19972											
ATF7IP2	80063	broad.mit.edu	37	chr16	10527480	10527480	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	aaaatatttgtgtaagtttgGaaaggcaaacagcattcctg	9	5	0	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr16:10527480G>C	uc002czu.2	+	4	1161	c.934G>C	c.(934-936)GAA>CAA	p.E312Q	ATF7IP2_uc002czv.2_Missense_Mutation_p.E312Q|ATF7IP2_uc010uyo.1_RNA|ATF7IP2_uc010uyp.1_Intron|ATF7IP2_uc002czw.2_Missense_Mutation_p.E312Q|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						TGTAAGTTTGGAAAGGCAAAC	0.328													C	10527480	C	C	10527480	3	2	277	1	0	0	0	0	1	0	0	0	1088	1175	41	5	940	5	ATF7IP2	16	10527480	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08		10527480	79827273	49	19973											
VWA3A	146177	broad.mit.edu	37	chr16	22137566	22137566	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttcatatccagcactccctgCggctgctgctggaggagcag	12	13	1	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr16:22137566C>T	uc010vbq.1	+	17	1696	c.1600C>T	c.(1600-1602)CGG>TGG	p.R534W	VWA3A_uc010bxd.2_RNA|VWA3A_uc010bxc.2_Missense_Mutation_p.R542W	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	534	VWFA 1.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		GCACTCCCTGCGGCTGCTGCT	0.512													T	22137566	T	T	22137566	3	4	277	1	0	0	0	0	1	0	0	0	17237	759	27	1	1666	1	VWA3A	16	22137566	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	11610086	22137566	68217187	50	19974											
PLCG2	5336	broad.mit.edu	37	chr16	81942086	81942086	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aagaaggtggagaagaggacGagtgccgagaagttgctgca	17	5	0	4			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr16:81942086G>A	uc002fgt.2	+	17	1775	c.1623G>A	c.(1621-1623)ACG>ACA	p.T541T	PLCG2_uc010chg.1_Silent_p.T541T	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	541	SH2 1.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						AGAAGAGGACGAGTGCCGAGA	0.552													A	81942086	A	A	81942086	2	1	277	1	0	0	0	0	0	0	0	1	12036	1045	37	2		2	PLCG2	16	81942086	Silent	SNP	G	TCGA-76-6661-01B-11D-1845-08	59804520	81942086	8412667	51	19975											
UBTF	7343	broad.mit.edu	37	chr17	42284949	42284949	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cgtcatcctcatcctcttcaTcatcctcctcggactccttg	4	18	5	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr17:42284949T>C	uc002igb.2	-	19	2109	c.2042A>G	c.(2041-2043)GAT>GGT	p.D681G	UBTF_uc002igc.2_Missense_Mutation_p.D644G|UBTF_uc010czs.2_Missense_Mutation_p.D681G|UBTF_uc002igd.2_Missense_Mutation_p.D644G|UBTF_uc010czt.2_Missense_Mutation_p.D681G	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	681	Asp/Glu/Ser-rich (acidic).				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		atcctcttcatcatcctcctc	0.453													C	42284949	C	C	42284949	3	2	277	1	0	0	0	0	1	0	0	0	16906	1435	50	4	260	4	UBTF	17	42284949	Missense_Mutation	SNP	T	TCGA-76-6661-01B-11D-1845-08		42284949	38910261	52	19976											
DSC2	1824	broad.mit.edu	37	chr18	28671015	28671015	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaaggaaaagtggaaaaggAcccaaggagttttctagcat	12	5	1	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr18:28671015A>C	uc002kwl.3	-	4	904	c.450T>G	c.(448-450)GGT>GGG	p.G150G	DSC2_uc002kwk.3_Silent_p.G150G	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	150	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GTGGAAAAGGACCCAAGGAGT	0.408													C	28671015	C	C	28671015	2	2	277	1	0	0	0	0	0	0	0	1	4766	262	10	5		5	DSC2	18	28671015	Silent	SNP	A	TCGA-76-6661-01B-11D-1845-08		28671015	49406233	53	19977											
DSG3	1830	broad.mit.edu	37	chr18	29046498	29046498	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	acattgttcttacagaatacAcgggtaaaacttctacaggc	7	9	2	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr18:29046498A>T	uc002kws.2	+	11	1526	c.1417A>T	c.(1417-1419)ACG>TCG	p.T473S		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	473	Cadherin 4.|Extracellular (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TACAGAATACACGGGTAAAAC	0.358													T	29046498	T	T	29046498	3	4	277	1	0	0	0	0	1	0	0	0	4778	159	6	5	1459	5	DSG3	18	29046498	Missense_Mutation	SNP	A	TCGA-76-6661-01B-11D-1845-08	375483	29046498	49030750	54	19978											
NEDD4L	23327	broad.mit.edu	37	chr18	55916158	55916158	+	Frame_Shift_Del	DEL	T	-	-													acccaaaatggaatgaagaaTtttatttcagggtaagtttt							TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr18:55916158delT	uc002lgy.2	+	4	506	c.232delT	c.(232-234)TTTfs	p.F78fs	NEDD4L_uc002lgz.2_Frame_Shift_Del_p.F78fs|NEDD4L_uc002lgx.2_Frame_Shift_Del_p.F78fs|NEDD4L_uc010xee.1_5'UTR|NEDD4L_uc002lhc.2_Frame_Shift_Del_p.F70fs|NEDD4L_uc002lhd.2_5'UTR|NEDD4L_uc002lhb.2_5'UTR|NEDD4L_uc002lhe.2_Frame_Shift_Del_p.F70fs|NEDD4L_uc002lhf.2_5'UTR|NEDD4L_uc010dpl.1_RNA|NEDD4L_uc002lhg.2_5'UTR|NEDD4L_uc002lhh.2_5'UTR	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	78	C2.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						GAATGAAGAATTTTATTTCAG	0.313													-	55916158	-	-	55916158	7	5	277	1	0	1	0	1	0	0	0	0	10311	1493	52	0	274	0	NEDD4L	18	55916158	Frame_Shift_Del	DEL	T	TCGA-76-6661-01B-11D-1845-08	26869660	55916158	22161090	55	19979											
CREB3L3	84699	broad.mit.edu	37	chr19	4171163	4171163	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagtcagcccagacaggcacCtgtgtcgcagtgagtcctgg	13	12	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr19:4171163C>T	uc002lzl.2	+	8	1082	c.966C>T	c.(964-966)ACC>ACT	p.T322T	CREB3L3_uc002lzm.2_Silent_p.T312T|CREB3L3_uc010xib.1_Silent_p.T311T|CREB3L3_uc010xic.1_Silent_p.L278L	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	322	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		AGACAGGCACCTGTGTCGCAG	0.602													T	4171163	T	T	4171163	2	4	277	1	0	0	0	0	0	0	0	1	3858	668	24	3		3	CREB3L3	19	4171163	Silent	SNP	C	TCGA-76-6661-01B-11D-1845-08		4171163	54957820	56	19980											
MYO1F	4542	broad.mit.edu	37	chr19	8616651	8616651	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaccaaagtcgcttctgtcGtccgtgccgtccacctggta	9	15	2	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr19:8616651G>A	uc002mkg.2	-	8	858	c.744C>T	c.(742-744)GAC>GAT	p.D248D	MYO1F_uc002mkh.2_Silent_p.D248D|MYO1F_uc010xkf.1_3'UTR	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	248	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CGCTTCTGTCGTCCGTGCCGT	0.582													A	8616651	A	A	8616651	2	1	277	1	0	0	0	0	0	0	0	1	10073	1136	40	1		1	MYO1F	19	8616651	Silent	SNP	G	TCGA-76-6661-01B-11D-1845-08	4445488	8616651	50512332	57	19981											
JAK3	3718	broad.mit.edu	37	chr19	17937673	17937673	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagggcgctgaatgatggcCggtcctgtgggctaggggcc	18	11	0	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr19:17937673C>T	uc002nhn.3	-	24	3354	c.3254G>A	c.(3253-3255)CGG>CAG	p.R1085Q	JAK3_uc010ebh.2_Intron	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	1085	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						GAATGATGGCCGGTCCTGTGG	0.632		2	Mis		acute megakaryocytic leukemia|								T	17937673	T	T	17937673	3	4	277	1	0	0	0	0	1	0	0	0	7939	652	23	2	124	2	JAK3	19	17937673	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	9321022	17937673	41191310	58	19982											
PAK4	10298	broad.mit.edu	37	chr19	39665625	39665625	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tggtggagatgtacaacagcTacctggtgggggacgagctc	16	8	0	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr19:39665625T>C	uc002okj.1	+	7	1614	c.1153T>C	c.(1153-1155)TAC>CAC	p.Y385H	PAK4_uc002okl.1_Missense_Mutation_p.Y385H|PAK4_uc002okn.1_Missense_Mutation_p.Y385H|PAK4_uc002okm.1_Missense_Mutation_p.Y232H|PAK4_uc002oko.1_Missense_Mutation_p.Y232H|PAK4_uc002okp.1_Missense_Mutation_p.Y295H	NM_001014831	NP_001014831	O96013	PAK4_HUMAN	p21-activated kinase 4 isoform 1	385	Protein kinase.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			GTACAACAGCTACCTGGTGGG	0.617													C	39665625	C	C	39665625	3	2	277	1	0	0	0	0	1	0	0	0	11403	1522	53	4	1167	4	PAK4	19	39665625	Missense_Mutation	SNP	T	TCGA-76-6661-01B-11D-1845-08	21727952	39665625	19463358	59	19983											
ZNF8	7554	broad.mit.edu	37	chr19	58805490	58805490	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcctcgatctgaaagccaaGcatcacgcaaggaagagggc	12	11	2	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr19:58805490G>A	uc002qry.1	+	4	446	c.316G>A	c.(316-318)GCA>ACA	p.A106T	ZNF8_uc002qrz.2_RNA	NM_021089	NP_066575	P17098	ZNF8_HUMAN	zinc finger protein 8	106					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		TGAAAGCCAAGCATCACGCAA	0.542													A	58805490	A	A	58805490	3	1	277	1	0	0	0	0	1	0	0	0	18164	971	34	3	330	3	ZNF8	19	58805490	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08	19139865	58805490	323493	60	19984											
BPI	671	broad.mit.edu	37	chr20	36964027	36964027	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagaaaggcttccctctccCgacgccggccagagtccagc	10	17	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr20:36964027C>T	uc002xib.2	+	14	1438	c.1376C>T	c.(1375-1377)CCG>CTG	p.P459L		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	459					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				TTCCCTCTCCCGACGCCGGCC	0.557													T	36964027	T	T	36964027	3	4	277	1	0	0	0	0	1	0	0	0	1490	652	23	2	1430	2	BPI	20	36964027	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08		36964027	26061493	61	19985											
TTPAL	79183	broad.mit.edu	37	chr20	43118147	43118147	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacagtgtgacgactccttgCgagctgtgaagtcacagctg	12	11	1	2			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr20:43118147C>T	uc002xmc.1	+	6	1118	c.994C>T	c.(994-996)CGA>TGA	p.R332*	TTPAL_uc002xmd.1_Nonsense_Mutation_p.R332*|TTPAL_uc010ggr.1_Nonsense_Mutation_p.R145*	NM_024331	NP_077307	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	332						intracellular	transporter activity			breast(1)	1						CGACTCCTTGCGAGCTGTGAA	0.547													T	43118147	T	T	43118147	4	4	277	1	0	0	0	0	0	1	0	0	16734	760	27	1	1008	1	TTPAL	20	43118147	Nonsense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	6154120	43118147	19907373	62	19986											
RIPK4	54101	broad.mit.edu	37	chr21	43162031	43162031	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	cctccaccgccaggtgcagcAggctggcaccgctgtccagt	12	17	0	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chr21:43162031A>T	uc002yzn.1	-	8	1370	c.1322T>A	c.(1321-1323)CTG>CAG	p.L441Q		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	441						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						CAGGTGCAGCAGGCTGGCACC	0.637													T	43162031	T	T	43162031	3	4	277	1	0	0	0	0	1	0	0	0	13383	188	7	5	1036	5	RIPK4	21	43162031	Missense_Mutation	SNP	A	TCGA-76-6661-01B-11D-1845-08		43162031	4967864	63	19987											
MAGEC3	139081	broad.mit.edu	37	chrX	140983301	140983301	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacagacaggaagatggccGccgagggctgaccgaggcgt	16	12	0	3			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chrX:140983301G>A	uc011mwp.1	+	6	1079	c.1079G>A	c.(1078-1080)CGC>CAC	p.R360H	MAGEC3_uc004fbs.2_Intron|MAGEC3_uc010nsj.2_5'Flank	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	360	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGATGGCCGCCGAGGGCTG	0.607													A	140983301	A	A	140983301	3	1	277	1	0	0	0	0	1	0	0	0	9182	1087	38	1	1101	1	MAGEC3	23	140983301	Missense_Mutation	SNP	G	TCGA-76-6661-01B-11D-1845-08		140983301	14287259	64	19988											
ARHGAP4	393	broad.mit.edu	37	chrX	153175809	153175809	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagcgtgggcccgaagcacaCggccaggttgtaggggtcca	16	12	0	0			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chrX:153175809C>T	uc004fjk.1	-	17	2014	c.1972G>A	c.(1972-1974)GTG>ATG	p.V658M	ARHGAP4_uc004fjj.1_Missense_Mutation_p.V9M|ARHGAP4_uc011mzf.1_Missense_Mutation_p.V635M|ARHGAP4_uc004fjl.1_Missense_Mutation_p.V698M|ARHGAP4_uc010nup.1_Intron	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	658	Rho-GAP.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGAAGCACACGGCCAGGTTG	0.677													T	153175809	T	T	153175809	3	4	277	1	0	0	0	0	1	0	0	0	885	536	19	1	892	1	ARHGAP4	23	153175809	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08	12192508	153175809	2094751	65	19989											
PCDH11Y	83259	broad.mit.edu	37	chrY	4966872	4966872	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aattgctctcataactgtgaCggataaggatgcggaccata	10	8	1	1			TCGA-76-6661-01B-11D-1845-08	TCGA-76-6661-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	8329c910-7ccf-4e84-b468-bd6cf23327a2	6fd1c469-0a02-4317-8b70-ff886a384a28	g.chrY:4966872C>T	uc004fqo.2	+	2	1987	c.1253C>T	c.(1252-1254)ACG>ATG	p.T418M	PCDH11Y_uc010nwg.1_Missense_Mutation_p.T407M|PCDH11Y_uc004fql.1_Missense_Mutation_p.T407M|PCDH11Y_uc004fqm.1_Missense_Mutation_p.T407M|PCDH11Y_uc004fqn.1_Missense_Mutation_p.T418M|PCDH11Y_uc004fqp.1_Missense_Mutation_p.T189M	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	418	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						ATAACTGTGACGGATAAGGAT	0.413													T	4966872	T	T	4966872	3	4	277	1	0	0	0	0	1	0	0	0	11509	536	19	1	1295	1	PCDH11Y	24	4966872	Missense_Mutation	SNP	C	TCGA-76-6661-01B-11D-1845-08		4966872	54406694	66	19990											
AMY2B	280	broad.mit.edu	37	chr1	104116388	104116388	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actggagaaagattatgtgcGttccaagattgccgaatata	10	6	0	3			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr1:104116388G>A	uc001duq.2	+	6	1188	c.572G>A	c.(571-573)CGT>CAT	p.R191H	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.R191H|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	191					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GATTATGTGCGTTCCAAGATT	0.413													A	104116388	A	A	104116388	3	1	278	1	0	0	0	0	1	0	0	0	595	1145	40	1	586	1	AMY2B	1	104116388	Missense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08		104116388	145134233	1	19991											
TCHH	7062	broad.mit.edu	37	chr1	152080354	152080354	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgttcctccctctcctggCggagctgttcctcctcgcgg	11	17	1	0			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr1:152080354C>T	uc001ezp.2	-	2	5339	c.5339G>A	c.(5338-5340)CGC>CAC	p.R1780H	TCHH_uc009wne.1_Missense_Mutation_p.R1780H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1780	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCTCCTGGCGGAGCTGTTC	0.592													T	152080354	T	T	152080354	3	4	278	1	0	0	0	0	1	0	0	0	15697	768	27	1	496	1	TCHH	1	152080354	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	47963966	152080354	97170267	2	19992											
REN	5972	broad.mit.edu	37	chr1	204135375	204135377	+	In_Frame_Del	DEL	AGC	-	-													caaaggtacaggagccccagAgcagcagcagcagtccccag					rs121917743		TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr1:204135375_204135377delAGC	uc001haq.2	-	1	89_91	c.45_47delGCT	c.(43-48)CTGCTC>CTC	p.15_16LL>L		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	15_16			L -> R (in HNFJ2; affects ER translocation and processing of nascent preprorenin, resulting in abolished prorenin and renin biosynthesis and secretion).		angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGAGCCCCAGAGCAGCAGCAGCA	0.581													-	204135377	-	-	204135375	7	5	278	1	0	1	0	1	0	0	0	0	13224	304	11	0	1213	0	REN	1	204135375	In_Frame_Del	DEL	AGC	TCGA-76-6662-01A-11D-1845-08	52055021	204135375	45115246	3	19993											
OR2L3	391192	broad.mit.edu	37	chr1	248224733	248224733	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctcactgtagtaactttctaCtatgcaccttttgtctacac	4	12	3	0			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr1:248224733C>A	uc001idx.1	+	1	750	c.750C>A	c.(748-750)TAC>TAA	p.Y250*	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TAACTTTCTACTATGCACCTT	0.502													A	248224733	A	A	248224733	4	1	278	1	0	0	0	0	0	1	0	0	11008	576	20	5	752	5	OR2L3	1	248224733	Nonsense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	44089358	248224733	1025888	4	19994											
GPAT2	150763	broad.mit.edu	37	chr2	96691751	96691751	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagcagcttctggcactgaCgatgtattcctgcccaagag	10	13	1	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr2:96691751C>T	uc002svf.2	-	12	1388	c.1165G>A	c.(1165-1167)GTC>ATC	p.V389I	GPAT2_uc002svd.2_Missense_Mutation_p.V202I|GPAT2_uc002sve.2_Missense_Mutation_p.V191I|GPAT2_uc002svg.2_Missense_Mutation_p.V262I|GPAT2_uc010yuh.1_Missense_Mutation_p.V318I|GPAT2_uc002svh.2_Missense_Mutation_p.V389I	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	389					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						CTGGCACTGACGATGTATTCC	0.612													T	96691751	T	T	96691751	3	4	278	1	0	0	0	0	1	0	0	0	6589	536	19	1	1266	1	GPAT2	2	96691751	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08		96691751	146507622	5	19995											
TTN	7273	broad.mit.edu	37	chr2	179395245	179395245	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	gtaagttggttttagacgttCcaccttcaccagaaatctca	7	10	2	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr2:179395245C>A	uc010zfg.1	-	307	98617	c.98393G>T	c.(98392-98394)GGA>GTA	p.G32798V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G26493V|TTN_uc010zfi.1_Missense_Mutation_p.G26426V|TTN_uc010zfj.1_Missense_Mutation_p.G26301V|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33725							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTAGACGTTCCACCTTCACC	0.363													A	179395245	A	A	179395245	3	1	278	1	0	0	0	0	1	0	0	0	16732	855	30	5	1902	5	TTN	2	179395245	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	82703494	179395245	63804128	6	19996											
TTN	7273	broad.mit.edu	37	chr2	179485027	179485027	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctggcaggagaagacagcGtcatcgaactcagtgactgt	13	9	2	3			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr2:179485027G>A	uc010zfg.1	-	197	38741	c.38517C>T	c.(38515-38517)GAC>GAT	p.D12839D	TTN_uc010zfh.1_Silent_p.D6534D|TTN_uc010zfi.1_Silent_p.D6467D|TTN_uc010zfj.1_Silent_p.D6342D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13766							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.D12839D(1)|p.D6342D(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAAGACAGCGTCATCGAACT	0.433													A	179485027	A	A	179485027	2	1	278	1	0	0	0	0	0	0	0	1	16732	1136	40	1		1	TTN	2	179485027	Silent	SNP	G	TCGA-76-6662-01A-11D-1845-08	89782	179485027	63714346	7	19997											
MYL3	4634	broad.mit.edu	37	chr3	46901034	46901034	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gccctccttgtcgaagacccGcagcccctccacgaagtcct	8	19	0	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr3:46901034G>A	uc003cql.1	-	4	505	c.412C>T	c.(412-414)CGG>TGG	p.R138W		NM_000258	NP_000249	P08590	MYL3_HUMAN	slow skeletal ventricular myosin alkali light	138	EF-hand 2.				cardiac muscle contraction|muscle filament sliding|positive regulation of ATPase activity|regulation of striated muscle contraction|regulation of the force of heart contraction|ventricular cardiac muscle tissue morphogenesis	A band|cytosol|I band|muscle myosin complex	actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle				0				BRCA - Breast invasive adenocarcinoma(193;0.00116)|KIRC - Kidney renal clear cell carcinoma(197;0.00557)|Kidney(197;0.0063)		TCGAAGACCCGCAGCCCCTCC	0.572													A	46901034	A	A	46901034	3	1	278	1	0	0	0	0	1	0	0	0	10048	1086	38	1	187	1	MYL3	3	46901034	Missense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08		46901034	151121396	8	19998											
PCOLCE2	26577	broad.mit.edu	37	chr3	142567280	142567280	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	cactctcgaggtctatgaatCggaaattgagaacgactact	9	9	2	2	rs143959509		TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr3:142567280C>T	uc003evd.2	-	3	423	c.227G>A	c.(226-228)CGA>CAA	p.R76Q		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	76	CUB 1.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						GTCTATGAATCGGAAATTGAG	0.473													T	142567280	T	T	142567280	3	4	278	1	0	0	0	0	1	0	0	0	11595	884	31	2	1048	2	PCOLCE2	3	142567280	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	95666246	142567280	55455150	9	19999											
SGEF	26084	broad.mit.edu	37	chr3	153840688	153840688	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	1	1	1	0	0	0	0	gtgaggtcgataacgacgtgGatagcccagggtctctgcgg	16	9	1	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr3:153840688G>C	uc011bog.1	+	2	1118	c.907G>C	c.(907-909)GAT>CAT	p.D303H	uc003ezu.1_5'Flank|SGEF_uc011boh.1_Missense_Mutation_p.D303H	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	303					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TAACGACGTGGATAGCCCAGG	0.597													C	153840688	C	C	153840688	3	2	278	1	0	0	0	0	1	0	0	0	14205	1174	41	5	909	5	SGEF	3	153840688	Missense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08	11273408	153840688	44181742	10	20000											
UGT2A3	79799	broad.mit.edu	37	chr4	69817091	69817091	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cttcataagcgtctgattgtAgataaagctctcacacatca	6	10	4	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr4:69817091A>G	uc003hef.2	-	1	419	c.388T>C	c.(388-390)TAC>CAC	p.Y130H	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	130	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GTCTGATTGTAGATAAAGCTC	0.383													G	69817091	G	G	69817091	3	3	278	1	0	0	0	0	1	0	0	0	16952	420	15	4	1219	4	UGT2A3	4	69817091	Missense_Mutation	SNP	A	TCGA-76-6662-01A-11D-1845-08		69817091	121337185	11	20001											
ANXA3	306	broad.mit.edu	37	chr4	79503370	79503370	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	agggtgatctctctggccacTttgagcatctcatggtggcc	12	11	3	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr4:79503370T>A	uc003hld.2	+	5	548	c.238T>A	c.(238-240)TTT>ATT	p.F80I	ANXA3_uc003hle.2_Missense_Mutation_p.F41I|ANXA3_uc010ijk.2_Missense_Mutation_p.F41I	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	80	Annexin 1.				defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						CTCTGGCCACTTTGAGCATCT	0.428													A	79503370	A	A	79503370	3	1	278	1	0	0	0	0	1	0	0	0	719	1609	56	5	252	5	ANXA3	4	79503370	Missense_Mutation	SNP	T	TCGA-76-6662-01A-11D-1845-08	9686279	79503370	111650906	12	20002											
ODZ3	55714	broad.mit.edu	37	chr4	183714569	183714569	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctaggacagcacctgcagttTttttatgctgacttaactta	7	9	0	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr4:183714569T>C	uc003ivd.1	+	25	6781	c.6744T>C	c.(6742-6744)TTT>TTC	p.F2248F		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2248	YD 22.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		ACCTGCAGTTTTTTTATGCTG	0.438													C	183714569	C	C	183714569	2	2	278	1	0	0	0	0	0	0	0	1	10836	1838	64	4		4	ODZ3	4	183714569	Silent	SNP	T	TCGA-76-6662-01A-11D-1845-08	104211199	183714569	7439707	13	20003											
PIK3R1	5295	broad.mit.edu	37	chr5	67589590	67589591	+	In_Frame_Ins	INS	-	TAT	TAT													tagggaaaaaattacatgaaINStataacactcagtttcaaga							TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr5:67589590_67589591insTAT	uc003jva.2	+	11	1913_1914	c.1353_1354insTAT	c.(1351-1356)insTAT	p.452_453insY	PIK3R1_uc003jvb.2_In_Frame_Ins_p.452_453insY|PIK3R1_uc003jvc.2_In_Frame_Ins_p.152_153insY|PIK3R1_uc003jvd.2_In_Frame_Ins_p.182_183insY|PIK3R1_uc003jve.2_In_Frame_Ins_p.131_132insY|PIK3R1_uc011crb.1_In_Frame_Ins_p.122_123insY	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	452_453					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.H450_E451del(2)|p.G446_Y452>VI(1)|p.Y452_Q455>SGGSRIK(1)|p.?(1)|p.E451_Y452del(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AATTACATGAATATAACACTCA	0.277			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			TAT	67589591	TAT	TAT	67589590	7	5	278	1	0	1	1	0	0	0	0	0	11918	98	4	0	1521	0	PIK3R1	5	67589590	In_Frame_Ins	INS	-	TCGA-76-6662-01A-11D-1845-08		67589590	113325670	14	20004											
GPR98	84059	broad.mit.edu	37	chr5	89953946	89953946	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgcaagagatgacaatgacGaggaaggagaagaattattc	12	5	0	5			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr5:89953946G>A	uc003kju.2	+	21	4699	c.4603G>A	c.(4603-4605)GAG>AAG	p.E1535K	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1535	Calx-beta 10.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGACAATGACGAGGAAGGAGA	0.358													A	89953946	A	A	89953946	3	1	278	1	0	0	0	0	1	0	0	0	6721	1059	37	2	4685	2	GPR98	5	89953946	Missense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08	22364356	89953946	90961314	15	20005											
STK10	6793	broad.mit.edu	37	chr5	171488225	171488225	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	ttgtcggtggtgagcctcttCatggccagctccaggtcctc	12	13	2	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr5:171488225C>T	uc003mbo.1	-	14	2430	c.2130G>A	c.(2128-2130)ATG>ATA	p.M710I		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	710	Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGAGCCTCTTCATGGCCAGCT	0.612													T	171488225	T	T	171488225	3	4	278	1	0	0	0	0	1	0	0	0	15285	826	29	3	800	3	STK10	5	171488225	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	81534279	171488225	9427035	16	20006											
IMPG1	3617	broad.mit.edu	37	chr6	76715225	76715225	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgtgtctcttaaagatggccGtaagttgcatctctgtggag	12	7	2	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr6:76715225G>A	uc003pik.1	-	10	1044	c.914C>T	c.(913-915)ACG>ATG	p.T305M		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	305	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AAAGATGGCCGTAAGTTGCAT	0.448													A	76715225	A	A	76715225	3	1	278	1	0	0	0	0	1	0	0	0	7728	1145	40	1	1511	1	IMPG1	6	76715225	Missense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08		76715225	94399842	17	20007											
ULBP1	80329	broad.mit.edu	37	chr6	150290460	150290460	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gtaagatgtggcttgaagaaTttttgatgtactgggaacaa	12	3	0	4			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr6:150290460T>G	uc003qnp.2	+	3	632	c.589T>G	c.(589-591)TTT>GTT	p.F197V		NM_025218	NP_079494	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1 precursor	197	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			pancreas(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		GCTTGAAGAATTTTTGATGTA	0.423													G	150290460	G	G	150290460	3	3	278	1	0	0	0	0	1	0	0	0	16969	1493	52	5	599	5	ULBP1	6	150290460	Missense_Mutation	SNP	T	TCGA-76-6662-01A-11D-1845-08	73575235	150290460	20824607	18	20008											
KIF25	3834	broad.mit.edu	37	chr6	168443281	168443281	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggccctgagggagatggcGtgcatcagccgcagccttgc	15	12	1	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr6:168443281G>A	uc003qwk.1	+	8	1132	c.870G>A	c.(868-870)GCG>GCA	p.A290A	KIF25_uc003qwl.1_Intron	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	290	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GGGAGATGGCGTGCATCAGCC	0.647													A	168443281	A	A	168443281	2	1	278	1	0	0	0	0	0	0	0	1	8293	1132	40	1		1	KIF25	6	168443281	Silent	SNP	G	TCGA-76-6662-01A-11D-1845-08	18152821	168443281	2671786	19	20009											
TFPI2	7980	broad.mit.edu	37	chr7	93516588	93516588	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	actaccttttgcacatgcacGtttgcaatcctccctgctaa	5	14	0	0			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr7:93516588G>A	uc003umy.1	-	4	691	c.616C>T	c.(616-618)CGT>TGT	p.R206C	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_Silent_p.N180N|TFPI2_uc003una.1_Missense_Mutation_p.R195C|TFPI2_uc003unb.1_Missense_Mutation_p.R212C|TFPI2_uc010lfg.1_Missense_Mutation_p.R82C	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	206	BPTI/Kunitz inhibitor 3.				blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			GCACATGCACGTTTGCAATCC	0.323													A	93516588	A	A	93516588	3	1	278	1	0	0	0	0	1	0	0	0	15806	1145	40	1	99	1	TFPI2	7	93516588	Missense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08		93516588	65622075	20	20010											
ZAN	7455	broad.mit.edu	37	chr7	100364654	100364654	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgccgccacctgcacagcctCgggtgacccccactacctga	9	19	0	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr7:100364654C>T	uc003uwj.2	+	25	4799	c.4634C>T	c.(4633-4635)TCG>TTG	p.S1545L	ZAN_uc003uwk.2_Missense_Mutation_p.S1545L|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Missense_Mutation_p.S122L	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1545	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCACAGCCTCGGGTGACCCC	0.607													T	100364654	T	T	100364654	3	4	278	1	0	0	0	0	1	0	0	0	17510	893	31	2	4728	2	ZAN	7	100364654	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	6848066	100364654	58774009	21	20011											
REPIN1	29803	broad.mit.edu	37	chr7	150069247	150069247	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ccgcttccggcacaaacccaAcctgctgtctcacagcaaga	7	17	1	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr7:150069247A>G	uc010lpq.1	+	4	1406	c.917A>G	c.(916-918)AAC>AGC	p.N306S	REPIN1_uc003whd.2_Missense_Mutation_p.N295S|REPIN1_uc010lpr.1_Missense_Mutation_p.N363S|REPIN1_uc003whc.2_Missense_Mutation_p.N306S|REPIN1_uc003whe.2_Missense_Mutation_p.N306S	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	306	C2H2-type 8.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CACAAACCCAACCTGCTGTCT	0.672													G	150069247	G	G	150069247	3	3	278	1	0	0	0	0	1	0	0	0	13227	43	2	4	1094	4	REPIN1	7	150069247	Missense_Mutation	SNP	A	TCGA-76-6662-01A-11D-1845-08	49704593	150069247	9069416	22	20012											
ATP6V1C1	528	broad.mit.edu	37	chr8	104064965	104064965	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttctttttcaaagggagtaActcagattgataatgacctg	8	6	3	3			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr8:104064965A>C	uc003ykz.3	+	6	633	c.388A>C	c.(388-390)ACT>CCT	p.T130P	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.T55P|ATP6V1C1_uc003yla.2_Missense_Mutation_p.T130P|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.T55P	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	130					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			AAAGGGAGTAACTCAGATTGA	0.318													C	104064965	C	C	104064965	3	2	278	1	0	0	0	0	1	0	0	0	1180	43	2	5	406	5	ATP6V1C1	8	104064965	Missense_Mutation	SNP	A	TCGA-76-6662-01A-11D-1845-08		104064965	42299057	23	20013											
NFKBIL2	4796	broad.mit.edu	37	chr8	145654644	145654644	+	Frame_Shift_Del	DEL	C	-	-													cagcgcagaggcgtctgctgCacagctgcagttcccggagc							TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr8:145654644delC	uc011llg.1	-	26	4034	c.4019delG	c.(4018-4020)TGCfs	p.C1340fs	VPS28_uc003zcr.1_5'Flank|VPS28_uc003zcs.1_5'Flank|VPS28_uc003zct.1_5'Flank	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	1340	LRR 7.				cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCGTCTGCTGCACAGCTGCAG	0.721													-	145654644	-	-	145654644	7	5	278	1	0	1	0	1	0	0	0	0	10382	710	25	0	121	0	NFKBIL2	8	145654644	Frame_Shift_Del	DEL	C	TCGA-76-6662-01A-11D-1845-08	41589679	145654644	709378	24	20014											
NAA35	60560	broad.mit.edu	37	chr9	88576949	88576950	+	Frame_Shift_Del	DEL	TC	-	-													taacgtggttagaaggccatTcactggcacagacagtattt							TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr9:88576949_88576950delTC	uc004aoi.3	+	6	507_508	c.370_371delTC	c.(370-372)TCAfs	p.S124fs	NAA35_uc004aoj.3_Frame_Shift_Del_p.S124fs|NAA35_uc004aok.1_Frame_Shift_Del_p.S124fs	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	124					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						AGAAGGCCATTCACTGGCACAG	0.366													-	88576950	-	-	88576949	7	5	278	1	0	1	0	1	0	0	0	0	10123	1783	62	0	388	0	NAA35	9	88576949	Frame_Shift_Del	DEL	TC	TCGA-76-6662-01A-11D-1845-08		88576949	52636482	25	20015											
RXRA	6256	broad.mit.edu	37	chr9	137309042	137309042	+	Nonsense_Mutation	SNP	G	T	T	1	0	0	0	0	1	0	0	0	0	0	0	agcgtggcaaggaccggaacGagaatgaggtggagtcgacc	17	8	0	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr9:137309042G>T	uc004cfb.2	+	5	811	c.649G>T	c.(649-651)GAG>TAG	p.E217*	RXRA_uc004cfc.1_Nonsense_Mutation_p.E120*|RXRA_uc004cfd.1_5'UTR	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	217	Hinge.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GGACCGGAACGAGAATGAGGT	0.677													T	137309042	T	T	137309042	4	4	278	1	0	0	0	0	0	1	0	0	13763	1059	37	5	667	5	RXRA	9	137309042	Nonsense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08	48732093	137309042	3904389	26	20016											
PTEN	5728	broad.mit.edu	37	chr10	89717672	89717672	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctccaattcaggacccacaCgacgggaagacaagttcatg	9	13	2	1	rs121909219		TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr10:89717672C>T	uc001kfb.2	+	8	1728	c.697C>T	c.(697-699)CGA>TGA	p.R233*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R233*(61)|p.R233fs*10(4)|p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R233fs*25(1)|p.R233fs*23(1)|p.R233R(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		AGGACCCACACGACGGGAAGA	0.423	R233*(JHUEM1_ENDOMETRIUM)|R233*(SW1783_CENTRAL_NERVOUS_SYSTEM)|R233*(NCIH1155_LUNG)|R233*(SF295_CENTRAL_NERVOUS_SYSTEM)|R233*(HEC59_ENDOMETRIUM)	31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			T	89717672	T	T	89717672	4	4	278	1	0	0	0	0	0	1	0	0	12738	528	19	1	723	1	PTEN	10	89717672	Nonsense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08		89717672	45817075	27	20017											
KIF20B	9585	broad.mit.edu	37	chr10	91498052	91498052	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gaaagagagcgctttcagaaCttacacaaggtgttacttgc	10	8	1	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr10:91498052C>A	uc001kgs.1	+	20	3526	c.3454C>A	c.(3454-3456)CTT>ATT	p.L1152I	KIF20B_uc001kgr.1_Missense_Mutation_p.L1112I|KIF20B_uc001kgt.1_Missense_Mutation_p.L363I|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1152					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						GCTTTCAGAACTTACACAAGG	0.343													A	91498052	A	A	91498052	3	1	278	1	0	0	0	0	1	0	0	0	8287	565	20	5	3408	5	KIF20B	10	91498052	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	1780380	91498052	44036695	28	20018											
WDR11	55717	broad.mit.edu	37	chr10	122649467	122649467	+	Silent	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tttgctcctggtaaaggaaaTcaaaaattaatagcaatgta	7	5	1	0			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr10:122649467T>C	uc010qtf.1	+	18	2527	c.2289T>C	c.(2287-2289)AAT>AAC	p.N763N	WDR11_uc010qte.1_Silent_p.N365N|WDR11_uc001lfd.1_Silent_p.N281N|WDR11_uc009xzn.2_Silent_p.N54N	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	763	WD 7.					integral to membrane					0						GTAAAGGAAATCAAAAATTAA	0.383													C	122649467	C	C	122649467	2	2	278	1	0	0	0	0	0	0	0	1	17270	1432	50	4		4	WDR11	10	122649467	Silent	SNP	T	TCGA-76-6662-01A-11D-1845-08	31151415	122649467	12885280	29	20019											
OR5D18	219438	broad.mit.edu	37	chr11	55587178	55587178	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tctcagattacccagaactgCaagtcccactcttcctggtt	6	14	2	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr11:55587178C>G	uc010rin.1	+	1	73	c.73C>G	c.(73-75)CAA>GAA	p.Q25E		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CCCAGAACTGCAAGTCCCACT	0.448													G	55587178	G	G	55587178	3	3	278	1	0	0	0	0	1	0	0	0	11157	711	25	5	75	5	OR5D18	11	55587178	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08		55587178	79419338	30	20020											
PAK1	5058	broad.mit.edu	37	chr11	77069990	77069992	+	In_Frame_Del	DEL	CAT	-	-													aatcactggtggtggggtagCatcatcatcatcatcatcct							TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr11:77069990_77069992delCAT	uc001oyh.3	-	6	1081_1083	c.548_550delATG	c.(547-552)GATGCT>GCT	p.D183del	PAK1_uc010rso.1_In_Frame_Del_p.D85del|PAK1_uc001oyg.3_In_Frame_Del_p.D183del|PAK1_uc001oyi.1_In_Frame_Del_p.D183del|PAK1_uc010rsn.1_5'UTR	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	183	Interaction with CRIPAK.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					GGTGGGGTAGcatcatcatcatc	0.429													-	77069992	-	-	77069990	7	5	278	1	0	1	0	1	0	0	0	0	11399	710	25	0	1180	0	PAK1	11	77069990	In_Frame_Del	DEL	CAT	TCGA-76-6662-01A-11D-1845-08	21482812	77069990	57936526	31	20021											
MAML2	84441	broad.mit.edu	37	chr11	95825767	95825767	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggctggggattttctcctgCccaaatggacctggtgatgg	15	9	1	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr11:95825767C>T	uc001pfw.1	-	2	2713	c.1428G>A	c.(1426-1428)GGG>GGA	p.G476G		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	476					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				TTTTCTCCTGCCCAAATGGAC	0.512			T	MECT1|CRTC3	salivary gland mucoepidermoid								T	95825767	T	T	95825767	2	4	278	1	0	0	0	0	0	0	0	1	9206	726	26	3		3	MAML2	11	95825767	Silent	SNP	C	TCGA-76-6662-01A-11D-1845-08	18755777	95825767	39180749	32	20022											
RB1	5925	broad.mit.edu	37	chr13	48919241	48919244	+	Frame_Shift_Del	DEL	AAAG	-	-													ataaattctttaacttactaAaagaaattgataccagtacc					rs121913296		TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr13:48919241_48919244delAAAG	uc001vcb.2	+	4	572_575	c.406_409delAAAG	c.(406-411)AAAGAAfs	p.K136fs	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	136_137			E -> D (in RB; unilateral form).		androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)|p.E137*(2)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAACTTACTAAAAGAAATTGATAC	0.284		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			-	48919244	-	-	48919241	7	5	278	1	0	1	0	1	0	0	0	0	13098	15	1	0	420	0	RB1	13	48919241	Frame_Shift_Del	DEL	AAAG	TCGA-76-6662-01A-11D-1845-08		48919241	66250637	33	20023											
REM2	161253	broad.mit.edu	37	chr14	23353987	23353987	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccagacgaagaggcagtatgCctgtcccctacaagcaccag	10	14	0	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr14:23353987C>T	uc001whf.1	+	2	273	c.208C>T	c.(208-210)CCT>TCT	p.P70S	REM2_uc010tnd.1_Missense_Mutation_p.P62S	NM_173527	NP_775798	Q8IYK8	REM2_HUMAN	rad and gem related GTP binding protein 2	70					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		AGGCAGTATGCCTGTCCCCTA	0.607													T	23353987	T	T	23353987	3	4	278	1	0	0	0	0	1	0	0	0	13223	739	26	3	214	3	REM2	14	23353987	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08		23353987	83995553	34	20024											
FMN1	342184	broad.mit.edu	37	chr15	33261062	33261062	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggggtgcaagtcctgggggtGgtggagcaggaggaggccct	22	7	0	0			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr15:33261062G>A	uc001zhf.3	-	4	2171	c.2171C>T	c.(2170-2172)CCA>CTA	p.P724L		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	947	FH1.|Pro-rich.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TCCTGGGGGTGGTGGAGCAGG	0.507													A	33261062	A	A	33261062	3	1	278	1	0	0	0	0	1	0	0	0	5949	1348	47	3	1475	3	FMN1	15	33261062	Missense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08		33261062	69270330	35	20025											
PLCB2	5330	broad.mit.edu	37	chr15	40590478	40590478	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggtgataatgggctcctcGtcagggggtttccccttcca	13	11	1	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr15:40590478G>A	uc001zld.2	-	11	1402	c.1101C>T	c.(1099-1101)GAC>GAT	p.D367D	PLCB2_uc010bbo.2_Silent_p.D367D|PLCB2_uc010ucm.1_Silent_p.D367D	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	367	PI-PLC X-box.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		TGGGCTCCTCGTCAGGGGGTT	0.602													A	40590478	A	A	40590478	2	1	278	1	0	0	0	0	0	0	0	1	12028	1136	40	1		1	PLCB2	15	40590478	Silent	SNP	G	TCGA-76-6662-01A-11D-1845-08	7329416	40590478	61940914	36	20026											
IGF1R	3480	broad.mit.edu	37	chr15	99456497	99456497	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gagtgagatcttgtacattcGcaccaatgcttcaggtatcc	9	10	2	1	rs45553041		TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr15:99456497G>T	uc002bul.2	+	8	1864	c.1814G>T	c.(1813-1815)CGC>CTC	p.R605L	IGF1R_uc010urq.1_Missense_Mutation_p.R605L|IGF1R_uc010bon.2_Missense_Mutation_p.R605L|IGF1R_uc010urr.1_Missense_Mutation_p.R55L	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	605	Fibronectin type-III 1.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TTGTACATTCGCACCAATGCT	0.532													T	99456497	T	T	99456497	3	4	278	1	0	0	0	0	1	0	0	0	7571	1087	38	5	1844	5	IGF1R	15	99456497	Missense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08	58866019	99456497	3074895	37	20027											
TP53	7157	broad.mit.edu	37	chr17	7578518	7578518	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcacagggcaggtcttggCcagttggcaaaacatcttgt	12	10	2	0	rs28934875		TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr17:7578518C>T	uc002gim.2	-	5	606	c.412G>A	c.(412-414)GCC>ACC	p.A138T	TP53_uc002gig.1_Missense_Mutation_p.A138T|TP53_uc002gih.2_Missense_Mutation_p.A138T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A6T|TP53_uc010cng.1_Missense_Mutation_p.A6T|TP53_uc002gii.1_Missense_Mutation_p.A6T|TP53_uc010cnh.1_Missense_Mutation_p.A138T|TP53_uc010cni.1_Missense_Mutation_p.A138T|TP53_uc002gij.2_Missense_Mutation_p.A138T|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A45T|TP53_uc002gio.2_Missense_Mutation_p.A6T|TP53_uc010vug.1_Missense_Mutation_p.A99T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	138	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> D (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> S (in LFS; germline mutation).|A -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A138V(17)|p.A138P(13)|p.0?(7)|p.A138fs*32(5)|p.A138T(4)|p.A138fs*11(3)|p.N131fs*27(2)|p.A138fs*31(1)|p.L137_W146del10(1)|p.K139fs*4(1)|p.F134_T140>S(1)|p.V73fs*9(1)|p.L137_A138insX(1)|p.K132_A138delKMFCQLA(1)|p.A138_V143delAKTCPV(1)|p.A138del(1)|p.A138_P142delAKTCP(1)|p.C135_A138delCQLA(1)|p.Q136_K139delQLAK(1)|p.A138A(1)|p.C135_T140delCQLAKT(1)|p.A138S(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGTCTTGGCCAGTTGGCAA	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			T	7578518	T	T	7578518	3	4	278	1	0	0	0	0	1	0	0	0	16378	739	26	3	886	3	TP53	17	7578518	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08		7578518	73616692	38	20028											
ABI3	51225	broad.mit.edu	37	chr17	47297534	47297534	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggctctctggtgttcagcagCgccgaaggtgtcggtggggc	18	10	2	0			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr17:47297534C>T	uc002iop.1	+	6	1146	c.648C>T	c.(646-648)AGC>AGT	p.S216S	ABI3_uc002ioq.1_Silent_p.S210S	NM_016428	NP_057512	Q9P2A4	ABI3_HUMAN	NESH protein isoform 1	216					cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			TGTTCAGCAGCGCCGAAGGTG	0.692										HNSCC(55;0.14)			T	47297534	T	T	47297534	2	4	278	1	0	0	0	0	0	0	0	1	90	767	27	1		1	ABI3	17	47297534	Silent	SNP	C	TCGA-76-6662-01A-11D-1845-08	39719016	47297534	33897676	39	20029											
DNAH17	8632	broad.mit.edu	37	chr17	76459049	76459049	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atctgctccagaaaggttttGggtgtggtgtagttgtagcg	15	5	1	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr17:76459049G>A	uc010dhp.1	-	2	273	c.51C>T	c.(49-51)CCC>CCT	p.P17P	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GAAAGGTTTTGGGTGTGGTGT	0.522													A	76459049	A	A	76459049	2	1	278	1	0	0	0	0	0	0	0	1	4601	1335	47	3		3	DNAH17	17	76459049	Silent	SNP	G	TCGA-76-6662-01A-11D-1845-08	29161515	76459049	4736161	40	20030											
TBCD	6904	broad.mit.edu	37	chr17	80858560	80858560	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggctttcctgagtacacgcaGccaatgatagaccacctggt	10	12	0	3			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr17:80858560G>A	uc002kfz.2	+	18	1813	c.1683G>A	c.(1681-1683)CAG>CAA	p.Q561Q	TBCD_uc002kfx.1_Silent_p.Q544Q|TBCD_uc002kfy.1_Silent_p.Q561Q|TBCD_uc002kgb.1_5'UTR	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	561	HEAT 2.				'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			AGTACACGCAGCCAATGATAG	0.318													A	80858560	A	A	80858560	2	1	278	1	0	0	0	0	0	0	0	1	15630	962	34	3		3	TBCD	17	80858560	Silent	SNP	G	TCGA-76-6662-01A-11D-1845-08	4399511	80858560	336650	41	20031											
ICAM1	3383	broad.mit.edu	37	chr19	10395175	10395175	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccaccctagagccaaggtgaCgctgaatggggttccagccc	12	14	0	3	rs141326678		TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr19:10395175C>T	uc002mnq.2	+	5	1341	c.1022C>T	c.(1021-1023)ACG>ATG	p.T341M	ICAM1_uc010xle.1_Missense_Mutation_p.T119M|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	341	Ig-like C2-type 4.|Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	GCCAAGGTGACGCTGAATGGG	0.642													T	10395175	T	T	10395175	3	4	278	1	0	0	0	0	1	0	0	0	7479	536	19	1	1040	1	ICAM1	19	10395175	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08		10395175	48733808	42	20032											
SCN1B	6324	broad.mit.edu	37	chr19	35523525	35523525	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctttgcatctcctgcaagcGccgcagcgagaccaacgctg	10	15	2	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr19:35523525G>A	uc002nxp.2	+	2	325	c.134G>A	c.(133-135)CGC>CAC	p.R45H	SCN1B_uc002nxo.1_Missense_Mutation_p.R45H|SCN1B_uc010xsg.1_Missense_Mutation_p.R45H	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta	45	Extracellular (Potential).|Ig-like C2-type.				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TCCTGCAAGCGCCGCAGCGAG	0.622													A	35523525	A	A	35523525	3	1	278	1	0	0	0	0	1	0	0	0	13915	1087	38	1	140	1	SCN1B	19	35523525	Missense_Mutation	SNP	G	TCGA-76-6662-01A-11D-1845-08	25128350	35523525	23605458	43	20033											
SPTBN4	57731	broad.mit.edu	37	chr19	41063199	41063199	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggacagattgaggagaagCggaggcggctgccccgcctg	18	10	0	3			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr19:41063199C>T	uc002ony.2	+	26	5646	c.5560C>T	c.(5560-5562)CGG>TGG	p.R1854W	SPTBN4_uc002onx.2_Missense_Mutation_p.R1854W|SPTBN4_uc002onz.2_Missense_Mutation_p.R1854W|SPTBN4_uc010egx.2_Missense_Mutation_p.R597W|SPTBN4_uc002ooa.2_Missense_Mutation_p.R530W	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1854	Spectrin 16.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGAGGAGAAGCGGAGGCGGCT	0.647													T	41063199	T	T	41063199	3	4	278	1	0	0	0	0	1	0	0	0	15120	759	27	1	5658	1	SPTBN4	19	41063199	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	5539674	41063199	18065784	44	20034											
KLK6	5653	broad.mit.edu	37	chr19	51466671	51466671	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtttggctgggcgtgccaggCgcaacagcatgatgtcctgg	16	10	0	1			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr19:51466671C>T	uc002pui.2	-	5	592	c.332G>A	c.(331-333)CGC>CAC	p.R111H	KLK6_uc010eoj.2_Intron|KLK6_uc002puh.2_Missense_Mutation_p.R120H|KLK6_uc002puj.2_Missense_Mutation_p.R4H|KLK6_uc010ycn.1_Missense_Mutation_p.R4H|KLK6_uc002pul.2_Missense_Mutation_p.R111H|KLK6_uc002pum.2_Missense_Mutation_p.R4H	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	111	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		GCGTGCCAGGCGCAACAGCAT	0.617													T	51466671	T	T	51466671	3	4	278	1	0	0	0	0	1	0	0	0	8408	768	27	1	414	1	KLK6	19	51466671	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	10403472	51466671	7662312	45	20035											
LILRA5	353514	broad.mit.edu	37	chr19	54822924	54822924	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgagccacactggagggtcaCgttctctcctgaggtcacca	11	13	3	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr19:54822924C>T	uc002qfe.2	-	5	592	c.472G>A	c.(472-474)GTG>ATG	p.V158M	LILRA5_uc002qff.2_Missense_Mutation_p.V146M|LILRA5_uc010yev.1_Missense_Mutation_p.V158M|LILRA5_uc010yew.1_Missense_Mutation_p.V146M|LILRA5_uc002qfh.1_Missense_Mutation_p.V146M|LILRA5_uc002qfg.1_Missense_Mutation_p.V158M	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	158	Extracellular (Potential).|Ig-like C2-type 2.				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGAGGGTCACGTTCTCTCCT	0.572													T	54822924	T	T	54822924	3	4	278	1	0	0	0	0	1	0	0	0	8788	536	19	1	525	1	LILRA5	19	54822924	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08	3356253	54822924	4306059	46	20036											
SIRPB1	10326	broad.mit.edu	37	chr20	1552398	1552398	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagacaagttggcagtcccaCgaagagggtccccctgcaag	12	13	0	2			TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chr20:1552398C>T	uc010gai.2	-	3	818	c.719G>A	c.(718-720)CGT>CAT	p.R240H	SIRPB1_uc002wfk.3_Intron	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	240	Ig-like C1-type 1.|Extracellular (Potential).				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						GGCAGTCCCACGAAGAGGGTC	0.622													T	1552398	T	T	1552398	3	4	278	1	0	0	0	0	1	0	0	0	14333	536	19	1	489	1	SIRPB1	20	1552398	Missense_Mutation	SNP	C	TCGA-76-6662-01A-11D-1845-08		1552398	61473122	47	20037											
KDM6A	7403	broad.mit.edu	37	chrX	44923045	44923048	+	Frame_Shift_Del	DEL	CTAT	-	-													aggagccgtggaaaaaccaaCtatctaactccactcaggta							TCGA-76-6662-01A-11D-1845-08	TCGA-76-6662-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	7f7c80ca-6ad9-4820-83ca-5248b3873eea	9e61f6fe-57d8-413b-a988-a3a283e6a3a7	g.chrX:44923045_44923048delCTAT	uc004dge.3	+	16	2281_2284	c.1906_1909delCTAT	c.(1906-1911)CTATCTfs	p.L636fs	KDM6A_uc010nhk.2_Frame_Shift_Del_p.L602fs|KDM6A_uc011mkz.1_Frame_Shift_Del_p.L688fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.L591fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.L643fs|KDM6A_uc011mlc.1_Frame_Shift_Del_p.L340fs|KDM6A_uc011mld.1_Frame_Shift_Del_p.L275fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	636_637					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GAAAAACCAACTATCTAACTCCAC	0.446			D|N|F|S		renal|oesophageal SCC|MM								-	44923048	-	-	44923045	7	5	278	1	0	1	0	1	0	0	0	0	8137	564	20	0	1968	0	KDM6A	23	44923045	Frame_Shift_Del	DEL	CTAT	TCGA-76-6662-01A-11D-1845-08		44923045	110347515	48	20038											
RPS6KA1	6195	broad.mit.edu	37	chr1	26883501	26883501	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgtgcagaagctataccgtCgtgagatcaagccacccttc	9	13	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr1:26883501C>T	uc001bmr.1	+	13	1157	c.994C>T	c.(994-996)CGT>TGT	p.R332C	RPS6KA1_uc010ofe.1_Missense_Mutation_p.R240C|RPS6KA1_uc010off.1_Missense_Mutation_p.R316C|RPS6KA1_uc001bms.1_Missense_Mutation_p.R341C|RPS6KA1_uc009vsl.1_Missense_Mutation_p.R175C	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	332	AGC-kinase C-terminal.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		GCTATACCGTCGTGAGATCAA	0.597													T	26883501	T	T	26883501	3	4	279	1	0	0	0	0	1	0	0	0	13650	884	31	2	1183	2	RPS6KA1	1	26883501	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08		26883501	222367120	1	20039											
SFPQ	6421	broad.mit.edu	37	chr1	35656550	35656550	+	Frame_Shift_Del	DEL	G	-	-													gctgtctacctctcatgggtGtatcatccagttcggctttg							TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr1:35656550delG	uc001bys.2	-	3	1157	c.1064delC	c.(1063-1065)ACAfs	p.T355fs	SFPQ_uc001byr.2_5'Flank	NM_005066	NP_005057	P23246	SFPQ_HUMAN	splicing factor proline/glutamine rich	355	RRM 1.				alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|protein binding|RNA binding		SFPQ/TFE3(6)	kidney(4)|soft_tissue(2)|ovary(1)|skin(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TCTCATGGGTGTATCATCCAG	0.438			T	TFE3	papillary renal cell								-	35656550	-	-	35656550	7	5	279	1	0	1	0	1	0	0	0	0	14160	1377	48	0	1091	0	SFPQ	1	35656550	Frame_Shift_Del	DEL	G	TCGA-76-6663-01A-11D-1845-08	8773049	35656550	213594071	2	20040											
CLDN19	149461	broad.mit.edu	37	chr1	43201615	43201615	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgttgggtctctctggctccGggcatgtgcagcagaggaag	16	9	2	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr1:43201615G>A	uc001cht.1	-	4	751	c.560C>T	c.(559-561)CCG>CTG	p.P187L	CLDN19_uc001chu.2_Missense_Mutation_p.P187L|CLDN19_uc010ojv.1_Missense_Mutation_p.R159W	NM_148960	NP_683763	Q8N6F1	CLD19_HUMAN	claudin 19 isoform a	187	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|response to stimulus|visual perception	basolateral plasma membrane|integral to membrane|tight junction	identical protein binding				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCTGGCTCCGGGCATGTGCA	0.677													A	43201615	A	A	43201615	3	1	279	1	0	0	0	0	1	0	0	0	3480	1116	39	2	238	2	CLDN19	1	43201615	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	7545065	43201615	206049006	3	20041											
CLCA1	1179	broad.mit.edu	37	chr1	86952277	86952277	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcagacagttgagctgggGtcctgggttgggatggtgac	18	7	0	3			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr1:86952277G>A	uc001dlt.2	+	7	1152	c.1023G>A	c.(1021-1023)GGG>GGA	p.G341G	CLCA1_uc001dls.1_Silent_p.G280G	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	341	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TTGAGCTGGGGTCCTGGGTTG	0.478													A	86952277	A	A	86952277	2	1	279	1	0	0	0	0	0	0	0	1	3457	1248	44	3		3	CLCA1	1	86952277	Silent	SNP	G	TCGA-76-6663-01A-11D-1845-08	43750662	86952277	162298344	4	20042											
CLCA4	22802	broad.mit.edu	37	chr1	87045055	87045055	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggggaaattgaagcaaaccCgccaagacctgaaattgatg	11	8	0	4			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr1:87045055C>T	uc009wcs.2	+	13	2185	c.2141C>T	c.(2140-2142)CCG>CTG	p.P714L	CLCA4_uc009wct.2_Missense_Mutation_p.P477L|CLCA4_uc009wcu.2_Missense_Mutation_p.P534L	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	714						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GAAGCAAACCCGCCAAGACCT	0.428													T	87045055	T	T	87045055	3	4	279	1	0	0	0	0	1	0	0	0	3459	652	23	2	2191	2	CLCA4	1	87045055	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	92778	87045055	162205566	5	20043											
SPTA1	6708	broad.mit.edu	37	chr1	158651339	158651339	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tgtctccaatccactctaagAtgtcagcacactcctgtaca	5	14	3	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr1:158651339A>G	uc001fst.1	-	4	708	c.509T>C	c.(508-510)ATC>ACC	p.I170T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	170	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCACTCTAAGATGTCAGCACA	0.537													G	158651339	G	G	158651339	3	3	279	1	0	0	0	0	1	0	0	0	15115	333	12	4	6946	4	SPTA1	1	158651339	Missense_Mutation	SNP	A	TCGA-76-6663-01A-11D-1845-08	71606284	158651339	90599282	6	20044											
PTPN14	5784	broad.mit.edu	37	chr1	214575057	214575057	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaagatttcctgtccaaatcCatccaaacgttcaacttcat	4	12	2	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr1:214575057C>T	uc001hkk.1	-	7	911	c.640G>A	c.(640-642)GGA>AGA	p.G214R	PTPN14_uc010pty.1_Missense_Mutation_p.G115R	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	214	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TGTCCAAATCCATCCAAACGT	0.423													T	214575057	T	T	214575057	3	4	279	1	0	0	0	0	1	0	0	0	12783	603	21	3	2975	3	PTPN14	1	214575057	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	55923718	214575057	34675564	7	20045											
SIPA1L2	57568	broad.mit.edu	37	chr1	232619633	232619633	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cttcaaaagctggtcccgccGtctcattgttatacatctct	6	13	3	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr1:232619633G>A	uc001hvg.2	-	4	2044	c.1886C>T	c.(1885-1887)ACG>ATG	p.T629M		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	629	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TGGTCCCGCCGTCTCATTGTT	0.448													A	232619633	A	A	232619633	3	1	279	1	0	0	0	0	1	0	0	0	14330	1145	40	1	3354	1	SIPA1L2	1	232619633	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	18044576	232619633	16630988	8	20046											
OR2M2	391194	broad.mit.edu	37	chr1	248344248	248344248	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tacctcataaactttatgttTtgctgtttgctaaattcttc	4	8	2	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr1:248344248T>A	uc010pzf.1	+	1	961	c.961T>A	c.(961-963)TTG>ATG	p.L321M		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	321	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACTTTATGTTTTGCTGTTTGC	0.373													A	248344248	A	A	248344248	3	1	279	1	0	0	0	0	1	0	0	0	11010	1838	64	5	963	5	OR2M2	1	248344248	Missense_Mutation	SNP	T	TCGA-76-6663-01A-11D-1845-08	15724615	248344248	906373	9	20047											
PXDN	7837	broad.mit.edu	37	chr2	1652977	1652977	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	attgggggggatcatgacagAgaagcagggggggtcgttgc	20	5	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr2:1652977A>C	uc002qxa.2	-	17	2639	c.2575T>G	c.(2575-2577)TCT>GCT	p.S859A		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	859					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ATCATGACAGAGAAGCAGGGG	0.667													C	1652977	C	C	1652977	3	2	279	1	0	0	0	0	1	0	0	0	12847	304	11	5	1892	5	PXDN	2	1652977	Missense_Mutation	SNP	A	TCGA-76-6663-01A-11D-1845-08		1652977	241546396	10	20048											
TTN	7273	broad.mit.edu	37	chr2	179496982	179496982	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gatcgaatgagttttcccttCgtcttgcattgagaccgacc	9	11	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr2:179496982C>T	uc010zfg.1	-	185	36159	c.35935G>A	c.(35935-35937)GAA>AAA	p.E11979K	TTN_uc010zfh.1_Missense_Mutation_p.E5674K|TTN_uc010zfi.1_Missense_Mutation_p.E5607K|TTN_uc010zfj.1_Missense_Mutation_p.E5482K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12906							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTTCCCTTCGTCTTGCATT	0.433													T	179496982	T	T	179496982	3	4	279	1	0	0	0	0	1	0	0	0	16732	893	31	2	64562	2	TTN	2	179496982	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	177844005	179496982	63702391	11	20049											
TTN	7273	broad.mit.edu	37	chr2	179497281	179497281	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	atcagtttgccacttgtgtgCttatcttcagcttcaaacat	6	10	4	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr2:179497281C>T	uc010zfg.1	-	184	35972	c.35748G>A	c.(35746-35748)AAG>AAA	p.K11916K	TTN_uc010zfh.1_Silent_p.K5611K|TTN_uc010zfi.1_Silent_p.K5544K|TTN_uc010zfj.1_Silent_p.K5419K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12843							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTTGTGTGCTTATCTTCAG	0.328													T	179497281	T	T	179497281	2	4	279	1	0	0	0	0	0	0	0	1	16732	796	28	3		3	TTN	2	179497281	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08	299	179497281	63702092	12	20050											
TTN	7273	broad.mit.edu	37	chr2	179647563	179647563	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagatagcaggatgtgctgaCggttccagcctcatttacag	11	10	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr2:179647563C>T	uc010zfg.1	-	18	3294	c.3070G>A	c.(3070-3072)GTC>ATC	p.V1024I	TTN_uc010zfh.1_Missense_Mutation_p.V978I|TTN_uc010zfi.1_Missense_Mutation_p.V978I|TTN_uc010zfj.1_Missense_Mutation_p.V978I|TTN_uc002unb.2_Missense_Mutation_p.V1024I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1024							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGTGCTGACGGTTCCAGCC	0.498													T	179647563	T	T	179647563	3	4	279	1	0	0	0	0	1	0	0	0	16732	536	19	1	108298	1	TTN	2	179647563	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	150282	179647563	63551810	13	20051											
MYO1B	4430	broad.mit.edu	37	chr2	192278803	192278803	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	accattccaaggggcttaccTggaaatcaacaagaacccca	7	13	1	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr2:192278803T>C	uc010fsg.2	+	28	3158	c.2903T>C	c.(2902-2904)CTG>CCG	p.L968P	MYO1B_uc002usq.2_Missense_Mutation_p.L910P|MYO1B_uc002usr.2_Missense_Mutation_p.L968P|MYO1B_uc002usu.2_Missense_Mutation_p.L213P|MYO1B_uc002usv.2_Missense_Mutation_p.L84P	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	968						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GGGGCTTACCTGGAAATCAAC	0.373													C	192278803	C	C	192278803	3	2	279	1	0	0	0	0	1	0	0	0	10069	1580	55	4	3009	4	MYO1B	2	192278803	Missense_Mutation	SNP	T	TCGA-76-6663-01A-11D-1845-08	12631240	192278803	50920570	14	20052											
QARS	5859	broad.mit.edu	37	chr3	49136953	49136953	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccgcacctaccgcacagcacCagttgctacaagctggagga	10	15	0	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr3:49136953C>A	uc003cvx.2	-	16	1521	c.1516G>T	c.(1516-1518)GGT>TGT	p.G506C	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Missense_Mutation_p.G361C|QARS_uc003cvy.2_Missense_Mutation_p.G361C|QARS_uc011bce.1_Missense_Mutation_p.G495C	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	506					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	CGCACAGCACCAGTTGCTACA	0.527													A	49136953	A	A	49136953	3	1	279	1	0	0	0	0	1	0	0	0	12871	594	21	5	847	5	QARS	3	49136953	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08		49136953	148885477	15	20053											
EPHA6	285220	broad.mit.edu	37	chr3	96945145	96945145	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tataaagcttttgctgggaaCacaaaatgttctaaatgtcc	7	7	1	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr3:96945145C>A	uc010how.1	+	4	1195	c.1152C>A	c.(1150-1152)AAC>AAA	p.N384K	EPHA6_uc003drp.1_Missense_Mutation_p.N384K	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	289	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TTGCTGGGAACACAAAATGTT	0.358													A	96945145	A	A	96945145	3	1	279	1	0	0	0	0	1	0	0	0	5171	477	17	5	1166	5	EPHA6	3	96945145	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	47808192	96945145	101077285	16	20054											
HCN1	348980	broad.mit.edu	37	chr5	45262329	45262329	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcatggggcagcgagggctgCgaggcggagagtggcctgac	20	9	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr5:45262329C>T	uc003jok.2	-	8	2392	c.2367G>A	c.(2365-2367)TCG>TCA	p.S789S		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	789	Cytoplasmic (Potential).			S -> W (in Ref. 2; AAC39759).		integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GCGAGGGCTGCGAGGCGGAGA	0.627													T	45262329	T	T	45262329	2	4	279	1	0	0	0	0	0	0	0	1	6996	755	27	1		1	HCN1	5	45262329	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08		45262329	135652931	17	20055											
GPR98	84059	broad.mit.edu	37	chr5	89986756	89986756	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aatggacagcttgctactggCgacctgcgagttgtctcagg	13	10	1	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr5:89986756C>T	uc003kju.2	+	31	6945	c.6849C>T	c.(6847-6849)GGC>GGT	p.G2283G	GPR98_uc003kjt.2_Missense_Mutation_p.A17V|GPR98_uc003kjv.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2283	Calx-beta 16.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGCTACTGGCGACCTGCGAG	0.493													T	89986756	T	T	89986756	2	4	279	1	0	0	0	0	0	0	0	1	6721	755	27	1		1	GPR98	5	89986756	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08	44724427	89986756	90928504	18	20056											
PCDHA11	56138	broad.mit.edu	37	chr5	140249736	140249736	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgataactctcctgaagtcGccgtgacttccttgtccctc	7	15	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr5:140249736G>A	uc003lia.2	+	1	1906	c.1048G>A	c.(1048-1050)GCC>ACC	p.A350T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.A350T	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	350	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGAAGTCGCCGTGACTTC	0.547													A	140249736	A	A	140249736	3	1	279	1	0	0	0	0	1	0	0	0	11521	1087	38	1	1050	1	PCDHA11	5	140249736	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	50262980	140249736	40665524	19	20057											
PCDHB4	56131	broad.mit.edu	37	chr5	140503426	140503426	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cggagcctgggctgttcggcGtgtgggcgcacaatggcgag	19	10	0	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr5:140503426G>A	uc003lip.1	+	1	1846	c.1846G>A	c.(1846-1848)GTG>ATG	p.V616M		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	616	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGTTCGGCGTGTGGGCGCA	0.677													A	140503426	A	A	140503426	3	1	279	1	0	0	0	0	1	0	0	0	11544	1145	40	1	1848	1	PCDHB4	5	140503426	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	253690	140503426	40411834	20	20058											
PDGFRB	5159	broad.mit.edu	37	chr5	149504343	149504343	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cctgagaatggctcaggccaTgagccgtggcctccaccacc	11	16	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr5:149504343T>A	uc003lro.2	-	13	2328	c.1859A>T	c.(1858-1860)CAT>CTT	p.H620L	PDGFRB_uc010jhd.2_Missense_Mutation_p.H459L	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	620	Cytoplasmic (Potential).|Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GCTCAGGCCATGAGCCGTGGC	0.597			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								A	149504343	A	A	149504343	3	1	279	1	0	0	0	0	1	0	0	0	11662	1464	51	5	1505	5	PDGFRB	5	149504343	Missense_Mutation	SNP	T	TCGA-76-6663-01A-11D-1845-08	9000917	149504343	31410917	21	20059											
MSX2	4488	broad.mit.edu	37	chr5	174152030	174152030	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gcaggaacccggccgatattCgccgccgccaagtgagtgcg	14	14	0	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr5:174152030C>T	uc003mcy.2	+	1	456	c.368C>T	c.(367-369)TCG>TTG	p.S123L		NM_002449	NP_002440	P35548	MSX2_HUMAN	msh homeobox 2	123					cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GGCCGATATTCGCCGCCGCCA	0.677													T	174152030	T	T	174152030	3	4	279	1	0	0	0	0	1	0	0	0	9896	893	31	2	370	2	MSX2	5	174152030	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	24647687	174152030	6763230	22	20060											
F13A1	2162	broad.mit.edu	37	chr6	6174842	6174842	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gctccagcgtcacgtcgaacGtctccttcttgaattctgcc	8	15	4	1	rs113599940		TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr6:6174842G>A	uc003mwv.2	-	12	1841	c.1718C>T	c.(1717-1719)ACG>ATG	p.T573M	F13A1_uc011dib.1_Missense_Mutation_p.T510M	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	573					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CACGTCGAACGTCTCCTTCTT	0.527													A	6174842	A	A	6174842	3	1	279	1	0	0	0	0	1	0	0	0	5340	1145	40	1	496	1	F13A1	6	6174842	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08		6174842	164940225	23	20061											
FTSJD2	23070	broad.mit.edu	37	chr6	37438827	37438827	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctgcagatcaaagctctggcGaaaatccatgcctttgttca	8	11	3	1	rs146308234		TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr6:37438827G>A	uc003ons.2	+	14	1789	c.1536G>A	c.(1534-1536)GCG>GCA	p.A512A		NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	512					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						AAGCTCTGGCGAAAATCCATG	0.418													A	37438827	A	A	37438827	2	1	279	1	0	0	0	0	0	0	0	1	6091	1045	37	2		2	FTSJD2	6	37438827	Silent	SNP	G	TCGA-76-6663-01A-11D-1845-08	31263985	37438827	133676240	24	20062											
SNAP91	9892	broad.mit.edu	37	chr6	84302667	84302667	+	Missense_Mutation	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	ccttggcaaagcactcaccaGataagaggtcagcagtgaga	11	10	2	3			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr6:84302667G>T	uc011dze.1	-	19	2161	c.1844C>A	c.(1843-1845)TCT>TAT	p.S615Y	SNAP91_uc011dzd.1_Missense_Mutation_p.S118Y|SNAP91_uc003pkb.2_Missense_Mutation_p.S552Y|SNAP91_uc003pkc.2_Missense_Mutation_p.S613Y|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Missense_Mutation_p.S613Y	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	615					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GCACTCACCAGATAAGAGGTC	0.448													T	84302667	T	T	84302667	3	4	279	1	0	0	0	0	1	0	0	0	14833	942	33	5	919	5	SNAP91	6	84302667	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	46863840	84302667	86812400	25	20063											
GPRC6A	222545	broad.mit.edu	37	chr6	117113591	117113591	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaataataacatagcatttgGggatgaatgtgcaatacagg	10	4	0	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr6:117113591G>T	uc003pxj.1	-	6	2517	c.2495C>A	c.(2494-2496)CCC>CAC	p.P832H	GPRC6A_uc003pxk.1_Missense_Mutation_p.P657H|GPRC6A_uc003pxl.1_Missense_Mutation_p.P761H	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	832	Cytoplasmic (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATAGCATTTGGGGATGAATGT	0.368													T	117113591	T	T	117113591	3	4	279	1	0	0	0	0	1	0	0	0	6728	1232	43	5	289	5	GPRC6A	6	117113591	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	32810924	117113591	54001476	26	20064											
INTS1	26173	broad.mit.edu	37	chr7	1538054	1538054	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gaccctgggcctaccttgggCgccagctctgagctgtgctg	14	14	1	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr7:1538054C>T	uc003skn.2	-	10	1520	c.1419G>A	c.(1417-1419)GCG>GCA	p.A473A	INTS1_uc003skq.2_Silent_p.A473A	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	473					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTACCTTGGGCGCCAGCTCTG	0.642													T	1538054	T	T	1538054	2	4	279	1	0	0	0	0	0	0	0	1	7775	755	27	1		1	INTS1	7	1538054	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08		1538054	157600609	27	20065											
ESRP1	54845	broad.mit.edu	37	chr8	95683852	95683852	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tggatttcctgggggagttcGccacagatattcgtactcat	11	9	1	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr8:95683852G>A	uc003ygq.3	+	11	1588	c.1405G>A	c.(1405-1407)GCC>ACC	p.A469T	ESRP1_uc003ygr.3_Missense_Mutation_p.A469T|ESRP1_uc003ygs.3_Missense_Mutation_p.A469T|ESRP1_uc003ygt.3_Missense_Mutation_p.A469T|ESRP1_uc003ygu.3_Missense_Mutation_p.A469T|ESRP1_uc003ygv.2_Missense_Mutation_p.A309T|ESRP1_uc003ygw.2_Missense_Mutation_p.A309T	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	469	RRM 3.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						GGGGGAGTTCGCCACAGATAT	0.438													A	95683852	A	A	95683852	3	1	279	1	0	0	0	0	1	0	0	0	5258	1087	38	1	1447	1	ESRP1	8	95683852	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08		95683852	50680170	28	20066											
BNC2	54796	broad.mit.edu	37	chr9	16435990	16435990	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccccttccatggattcctcGcccagtttgggctccgaaga	9	15	0	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr9:16435990G>A	uc003zml.2	-	6	2342	c.2202C>T	c.(2200-2202)GGC>GGT	p.G734G	BNC2_uc011lmw.1_Silent_p.G639G|BNC2_uc003zmm.2_Silent_p.G692G|BNC2_uc003zmq.1_Silent_p.G748G|BNC2_uc003zmr.1_Silent_p.G771G|BNC2_uc003zmp.1_Silent_p.G762G|BNC2_uc010mij.1_Silent_p.G656G|BNC2_uc011lmv.1_Silent_p.G560G|BNC2_uc003zmo.1_Silent_p.G656G|BNC2_uc003zmj.2_Silent_p.G499G|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Silent_p.G499G|BNC2_uc003zmn.1_Silent_p.G499G	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	734					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		TGGATTCCTCGCCCAGTTTGG	0.517													A	16435990	A	A	16435990	2	1	279	1	0	0	0	0	0	0	0	1	1475	1074	38	1		1	BNC2	9	16435990	Silent	SNP	G	TCGA-76-6663-01A-11D-1845-08		16435990	124777441	29	20067											
LINGO2	158038	broad.mit.edu	37	chr9	27948963	27948963	+	Silent	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctgtttttgtgcttgcctttCcctcggctccacacaaaaag	7	13	0	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr9:27948963C>A	uc003zqu.1	-	2	1901	c.1707G>T	c.(1705-1707)GGG>GGT	p.G569G	LINGO2_uc010mjf.1_Silent_p.G569G|LINGO2_uc003zqv.1_Silent_p.G569G	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	569	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		GCTTGCCTTTCCCTCGGCTCC	0.463													A	27948963	A	A	27948963	2	1	279	1	0	0	0	0	0	0	0	1	8815	842	30	5		5	LINGO2	9	27948963	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08	11512973	27948963	113264468	30	20068											
PHF2	5253	broad.mit.edu	37	chr9	96408031	96408031	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gggctgggtctggctgtcccGgcccccacgttctatgtcag	14	14	3	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr9:96408031G>A	uc004aub.2	+	4	567	c.420G>A	c.(418-420)CCG>CCA	p.P140P	PHF2_uc011lug.1_Silent_p.P23P	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	140					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		TGGCTGTCCCGGCCCCCACGT	0.627													A	96408031	A	A	96408031	2	1	279	1	0	0	0	0	0	0	0	1	11830	1103	39	2		2	PHF2	9	96408031	Silent	SNP	G	TCGA-76-6663-01A-11D-1845-08	68459068	96408031	44805400	31	20069											
OR13C8	138802	broad.mit.edu	37	chr9	107331658	107331658	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtaatctttccttcctcgaCgtttgctacacaagttcctc	5	13	1	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr9:107331658C>T	uc011lvo.1	+	1	210	c.210C>T	c.(208-210)GAC>GAT	p.D70D		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCTTCCTCGACGTTTGCTACA	0.423													T	107331658	T	T	107331658	2	4	279	1	0	0	0	0	0	0	0	1	10938	535	19	1		1	OR13C8	9	107331658	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08	10923627	107331658	33881773	32	20070											
ZNF79	7633	broad.mit.edu	37	chr9	130207274	130207274	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cttcagtgagagctcagcccTcattcggcatcatataatcc	7	13	4	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr9:130207274T>C	uc004bqw.3	+	5	1709	c.1295T>C	c.(1294-1296)CTC>CCC	p.L432P	ZNF79_uc011maf.1_Missense_Mutation_p.L408P|ZNF79_uc011mag.1_Missense_Mutation_p.L408P	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	432	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						AGCTCAGCCCTCATTCGGCAT	0.443													C	130207274	C	C	130207274	3	2	279	1	0	0	0	0	1	0	0	0	18158	1551	54	4	1313	4	ZNF79	9	130207274	Missense_Mutation	SNP	T	TCGA-76-6663-01A-11D-1845-08	22875616	130207274	11006157	33	20071											
KNDC1	85442	broad.mit.edu	37	chr10	135020649	135020649	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ccgctccggcaggtcatgtaCgcggaacgctggggcctgga	16	13	1	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr10:135020649C>A	uc001llz.1	+	20	3589	c.3588C>A	c.(3586-3588)TAC>TAA	p.Y1196*	KNDC1_uc001lma.1_3'UTR	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1196					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		AGGTCATGTACGCGGAACGCT	0.657													A	135020649	A	A	135020649	4	1	279	1	0	0	0	0	0	1	0	0	8426	547	19	5	3666	5	KNDC1	10	135020649	Nonsense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08		135020649	514098	34	20072											
MRGPRX1	259249	broad.mit.edu	37	chr11	18955702	18955702	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtcacgtacagcctggtcagCggtatcttccgggatccaca	11	13	3	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr11:18955702C>T	uc001mpg.2	-	1	848	c.630G>A	c.(628-630)CCG>CCA	p.P210P		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	210	Cytoplasmic (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						GCCTGGTCAGCGGTATCTTCC	0.507													T	18955702	T	T	18955702	2	4	279	1	0	0	0	0	0	0	0	1	9766	755	27	1		1	MRGPRX1	11	18955702	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08		18955702	116050814	35	20073											
PIK3C2G	5288	broad.mit.edu	37	chr12	18435195	18435195	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	tacgagagtgaaattgatgaAaacaccttttttgtgcccac	8	8	0	4			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr12:18435195A>G	uc001rdt.2	+	2	296	c.180A>G	c.(178-180)GAA>GAG	p.E60E	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Silent_p.E60E|PIK3C2G_uc010sic.1_5'UTR	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	60					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				AAATTGATGAAAACACCTTTT	0.398													G	18435195	G	G	18435195	2	3	279	1	0	0	0	0	0	0	0	1	11911	11	1	4		4	PIK3C2G	12	18435195	Silent	SNP	A	TCGA-76-6663-01A-11D-1845-08		18435195	115416700	36	20074											
GLI1	2735	broad.mit.edu	37	chr12	57864141	57864141	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	tgggccccccagtctctcttGaacgccgcagcagcagctcc	10	18	2	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr12:57864141G>A	uc001snx.2	+	12	1696	c.1618G>A	c.(1618-1620)GAA>AAA	p.E540K	GLI1_uc009zpq.2_Missense_Mutation_p.E412K	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	540					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			AGTCTCTCTTGAACGCCGCAG	0.612													A	57864141	A	A	57864141	3	1	279	1	0	0	0	0	1	0	0	0	6437	1291	45	3	1660	3	GLI1	12	57864141	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	39428946	57864141	75987754	37	20075											
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100433500	100433500	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcagatcatactttccactGgtcagcagcactgaatcgct	7	12	3	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr12:100433500G>A	uc001tgq.2	-	20	4378	c.4149C>T	c.(4147-4149)ACC>ACT	p.T1383T	UHRF1BP1L_uc001tgp.2_Silent_p.T1033T	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	1383										ovary(2)	2						ACTTTCCACTGGTCAGCAGCA	0.428													A	100433500	A	A	100433500	2	1	279	1	0	0	0	0	0	0	0	1	16966	1335	47	3		3	UHRF1BP1L	12	100433500	Silent	SNP	G	TCGA-76-6663-01A-11D-1845-08	42569359	100433500	33418395	38	20076											
DNAH10	196385	broad.mit.edu	37	chr12	124298408	124298408	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tctctagtcatggaactcagAtatagggacgtccaggagcg	12	9	3	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr12:124298408A>C	uc001uft.3	+	20	3400	c.3375A>C	c.(3373-3375)AGA>AGC	p.R1125S	DNAH10_uc010tav.1_3'UTR|DNAH10_uc010taw.1_3'UTR	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1125	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGGAACTCAGATATAGGGACG	0.383													C	124298408	C	C	124298408	3	2	279	1	0	0	0	0	1	0	0	0	4598	330	12	5	3453	5	DNAH10	12	124298408	Missense_Mutation	SNP	A	TCGA-76-6663-01A-11D-1845-08	23864908	124298408	9553487	39	20077											
RB1	5925	broad.mit.edu	37	chr13	49039399	49039399	+	Nonsense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	cccttacaagtttcctagttCacccttacggattcctggag	7	13	1	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr13:49039399C>A	uc001vcb.2	+	23	2550	c.2384C>A	c.(2383-2385)TCA>TAA	p.S795*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	795	Interaction with LIMD1.|Domain C; mediates interaction with E4F1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTCCTAGTTCACCCTTACGG	0.393		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			A	49039399	A	A	49039399	4	1	279	1	0	0	0	0	0	1	0	0	13098	838	29	5	2474	5	RB1	13	49039399	Nonsense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08		49039399	66130479	40	20078											
AHNAK2	113146	broad.mit.edu	37	chr14	105414185	105414185	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctccaggtcagcggaaggggGctgaatgctgaggtcagtgg	18	8	2	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr14:105414185G>A	uc010axc.1	-	7	7723	c.7603C>T	c.(7603-7605)CCC>TCC	p.P2535S	AHNAK2_uc001ypx.2_Missense_Mutation_p.P2435S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2535						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCGGAAGGGGGCTGAATGCTG	0.667													A	105414185	A	A	105414185	3	1	279	1	0	0	0	0	1	0	0	0	415	1203	42	3	9788	3	AHNAK2	14	105414185	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08		105414185	1935355	41	20079											
CEP152	22995	broad.mit.edu	37	chr15	49030645	49030645	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctttcctggctccaaatacGtggtttcttctgacaggtat	8	10	3	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr15:49030645G>A	uc001zwy.2	-	26	4800	c.4766C>T	c.(4765-4767)ACG>ATG	p.T1589M	CEP152_uc001zwz.2_Missense_Mutation_p.T1645M	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1589					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CTCCAAATACGTGGTTTCTTC	0.383													A	49030645	A	A	49030645	3	1	279	1	0	0	0	0	1	0	0	0	3248	1145	40	1	202	1	CEP152	15	49030645	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08		49030645	53500747	42	20080											
LASS3	204219	broad.mit.edu	37	chr15	100996164	100996164	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	cagtaaaggtgaaggacctgCaagatcatgagctgtaggtt	13	6	1	3			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr15:100996164C>A	uc002bvz.2	-	12	1435	c.933G>T	c.(931-933)TTG>TTT	p.L311F	LASS3_uc002bwa.2_Missense_Mutation_p.L322F|LASS3_uc002bwb.2_Missense_Mutation_p.L311F	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	311	Helical; (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			GAAGGACCTGCAAGATCATGA	0.393													A	100996164	A	A	100996164	3	1	279	1	0	0	0	0	1	0	0	0	8640	709	25	5	226	5	LASS3	15	100996164	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	51965519	100996164	1535228	43	20081											
ZP2	7783	broad.mit.edu	37	chr16	21216830	21216830	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgaagccttccttcatggCctctggcagggtcagagttt	12	11	3	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr16:21216830C>T	uc002dii.2	-	7	604	c.604G>A	c.(604-606)GCC>ACC	p.A202T	ZP2_uc010bwn.1_Missense_Mutation_p.A241T|ZP2_uc010bwo.2_Missense_Mutation_p.A241T	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	202	Extracellular (Potential).				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		TCCTTCATGGCCTCTGGCAGG	0.493													T	21216830	T	T	21216830	3	4	279	1	0	0	0	0	1	0	0	0	18213	739	26	3	1685	3	ZP2	16	21216830	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08		21216830	69137923	44	20082											
TAOK2	9344	broad.mit.edu	37	chr16	29990328	29990328	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccttcaggaggtagagatcgCagctgtgacccacggggcgc	15	12	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr16:29990328C>T	uc002dva.1	+	6	1169	c.386C>T	c.(385-387)GCA>GTA	p.A129V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.A129V|TAOK2_uc002dvc.1_Missense_Mutation_p.A129V|TAOK2_uc010bzm.1_Missense_Mutation_p.A129V|TAOK2_uc002dvd.1_5'Flank	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	129	Protein kinase.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GTAGAGATCGCAGCTGTGACC	0.577													T	29990328	T	T	29990328	3	4	279	1	0	0	0	0	1	0	0	0	15545	710	25	3	404	3	TAOK2	16	29990328	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	8773498	29990328	60364425	45	20083											
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr17:7577538C>A	uc002gim.2	-	7	937	c.743G>T	c.(742-744)CGG>CTG	p.R248L	TP53_uc002gig.1_Missense_Mutation_p.R248L|TP53_uc002gih.2_Missense_Mutation_p.R248L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116L|TP53_uc010cng.1_Missense_Mutation_p.R116L|TP53_uc002gii.1_Missense_Mutation_p.R116L|TP53_uc010cnh.1_Missense_Mutation_p.R248L|TP53_uc010cni.1_Missense_Mutation_p.R248L|TP53_uc002gij.2_Missense_Mutation_p.R248L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155L|TP53_uc002gio.2_Missense_Mutation_p.R116L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577538	A	A	7577538	3	1	279	1	0	0	0	0	1	0	0	0	16378	652	23	5	547	5	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08		7577538	73617672	46	20084											
COPS3	8533	broad.mit.edu	37	chr17	17163668	17163668	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agatgacaagcattgcttcaCcagccccatgttgttatcgc	8	12	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr17:17163668C>A	uc002grd.2	-	8	974	c.883G>T	c.(883-885)GTG>TTG	p.V295L	COPS3_uc010vwv.1_Missense_Mutation_p.V275L|COPS3_uc010vww.1_Missense_Mutation_p.V165L	NM_003653	NP_003644	Q9UNS2	CSN3_HUMAN	COP9 constitutive photomorphogenic homolog	295	PCI.				cullin deneddylation|response to light stimulus|signal transduction	cytoplasm|signalosome	protein binding			skin(1)	1						CATTGCTTCACCAGCCCCATG	0.488													A	17163668	A	A	17163668	3	1	279	1	0	0	0	0	1	0	0	0	3734	507	18	5	408	5	COPS3	17	17163668	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	9586130	17163668	64031542	47	20085											
NF1	4763	broad.mit.edu	37	chr17	29497003	29497003	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggattgtgcaaaattaaaaCgactcctgaagggtaagttt	10	5	0	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr17:29497003C>T	uc002hgg.2	+	5	907	c.574C>T	c.(574-576)CGA>TGA	p.R192*	NF1_uc002hge.1_Nonsense_Mutation_p.R192*|NF1_uc002hgf.1_Nonsense_Mutation_p.R192*|NF1_uc002hgh.2_Nonsense_Mutation_p.R192*|NF1_uc010csn.1_Intron	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	192					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.R192*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AAAATTAAAACGACTCCTGAA	0.284			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			T	29497003	T	T	29497003	4	4	279	1	0	0	0	0	0	1	0	0	10356	528	19	1	592	1	NF1	17	29497003	Nonsense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	12333335	29497003	51698207	48	20086											
CCL4	6351	broad.mit.edu	37	chr17	34432024	34432024	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	accagcagcctctgctcccaGccagctgtggtgtgagtatc	11	14	1	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr17:34432024G>A	uc002hkw.1	+	2	259	c.180G>A	c.(178-180)CAG>CAA	p.Q60Q	CCL4_uc002hkx.1_Intron	NM_002984	NP_002975	P13236	CCL4_HUMAN	chemokine C-C motif ligand 4 isoform 1	60					cell adhesion|cell-cell signaling|cellular component movement|chemotaxis|establishment or maintenance of cell polarity|immune response|inflammatory response|response to virus|viral genome replication	extracellular space	chemokine activity|receptor signaling protein tyrosine kinase activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TCTGCTCCCAGCCAGCTGTGG	0.572													A	34432024	A	A	34432024	2	1	279	1	0	0	0	0	0	0	0	1	2902	962	34	3		3	CCL4	17	34432024	Silent	SNP	G	TCGA-76-6663-01A-11D-1845-08	4935021	34432024	46763186	49	20087											
GH1	2688	broad.mit.edu	37	chr17	61995751	61995751	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agctggtgcagacgatgggcGcggagcatagcgttgtcaaa	16	8	1	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr17:61995751G>A	uc002jdj.2	-	2	188	c.126C>T	c.(124-126)CGC>CGT	p.R42R	GH1_uc002jdi.2_Silent_p.R42R|GH1_uc002jdk.2_Silent_p.R42R|GH1_uc002jdl.2_Silent_p.R42R|GH1_uc002jdm.2_Intron|GH1_uc002jdn.2_Silent_p.R42R	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	42			R -> C (in IGHD1B; reduced secretion).		glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						GACGATGGGCGCGGAGCATAG	0.582													A	61995751	A	A	61995751	2	1	279	1	0	0	0	0	0	0	0	1	6367	1074	38	1		1	GH1	17	61995751	Silent	SNP	G	TCGA-76-6663-01A-11D-1845-08	27563727	61995751	19199459	50	20088											
LAMA1	284217	broad.mit.edu	37	chr18	7009321	7009321	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acagacataaaatcctctcgCgtgacaggtttttcagaaac	7	10	2	3			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr18:7009321C>T	uc002knm.2	-	27	4012	c.3918G>A	c.(3916-3918)ACG>ACA	p.T1306T	LAMA1_uc010wzj.1_Silent_p.T782T	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1306	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATCCTCTCGCGTGACAGGTT	0.403													T	7009321	T	T	7009321	2	4	279	1	0	0	0	0	0	0	0	1	8605	755	27	1		1	LAMA1	18	7009321	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08		7009321	71067927	51	20089											
ONECUT2	9480	broad.mit.edu	37	chr18	55143729	55143729	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caattcccagaagaagtcccGcctggtgttcactgacctcc	8	15	1	3			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr18:55143729G>A	uc002lgo.2	+	2	1321	c.1289G>A	c.(1288-1290)CGC>CAC	p.R430H		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	430	Homeobox.				organ morphogenesis	nucleus	sequence-specific DNA binding	p.R430H(1)		ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		AAGAAGTCCCGCCTGGTGTTC	0.517													A	55143729	A	A	55143729	3	1	279	1	0	0	0	0	1	0	0	0	10869	1087	38	1	1295	1	ONECUT2	18	55143729	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	48134408	55143729	22933519	52	20090											
MATK	4145	broad.mit.edu	37	chr19	3779708	3779708	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggactcacgtcatgacggccGtctcgtccaggaaggcctgg	14	13	3	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr19:3779708G>A	uc002lyt.2	-	9	1230	c.830C>T	c.(829-831)ACG>ATG	p.T277M	MATK_uc002lyv.2_Missense_Mutation_p.T278M|MATK_uc002lyu.2_Missense_Mutation_p.T236M|MATK_uc010dtq.2_Missense_Mutation_p.T277M	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	277	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CATGACGGCCGTCTCGTCCAG	0.677													A	3779708	A	A	3779708	3	1	279	1	0	0	0	0	1	0	0	0	9332	1145	40	1	717	1	MATK	19	3779708	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08		3779708	55349275	53	20091											
TUBB4	10382	broad.mit.edu	37	chr19	6495224	6495224	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgaactcgccctcctcggccGtggcgtcctggtactgctgg	13	16	0	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr19:6495224G>A	uc002mfg.1	-	4	1393	c.1286C>T	c.(1285-1287)ACG>ATG	p.T429M	TUBB4_uc002mff.1_Missense_Mutation_p.T357M|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	429					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		CTCCTCGGCCGTGGCGTCCTG	0.622													A	6495224	A	A	6495224	3	1	279	1	0	0	0	0	1	0	0	0	16755	1145	40	1	52	1	TUBB4	19	6495224	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	2715516	6495224	52633759	54	20092											
ZNF536	9745	broad.mit.edu	37	chr19	31039823	31039823	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agcggtgcatggaccggccaCgtggaccctgcattttgtaa	13	11	0	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr19:31039823C>T	uc002nsu.1	+	4	3435	c.3297C>T	c.(3295-3297)CAC>CAT	p.H1099H	ZNF536_uc010edd.1_Silent_p.H1099H	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1099					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGACCGGCCACGTGGACCCTG	0.542													T	31039823	T	T	31039823	2	4	279	1	0	0	0	0	0	0	0	1	17971	535	19	1		1	ZNF536	19	31039823	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08	24544599	31039823	28089160	55	20093											
ZNF181	339318	broad.mit.edu	37	chr19	35232341	35232341	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaaaaactctatgagtgtcGtatatgtggaaaggccttca	10	6	2	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr19:35232341G>A	uc002nvu.3	+	4	1518	c.1055G>A	c.(1054-1056)CGT>CAT	p.R352H	ZNF181_uc010xsa.1_Missense_Mutation_p.R351H|ZNF181_uc010xsb.1_Missense_Mutation_p.R351H|ZNF181_uc010xsc.1_Missense_Mutation_p.R287H	NM_001029997	NP_001025168	Q2M3W8	ZN181_HUMAN	zinc finger protein 181 isoform 1	352	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TATGAGTGTCGTATATGTGGA	0.373													A	35232341	A	A	35232341	3	1	279	1	0	0	0	0	1	0	0	0	17746	1145	40	1	1069	1	ZNF181	19	35232341	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	4192518	35232341	23896642	56	20094											
ZNF345	25850	broad.mit.edu	37	chr19	37367974	37367974	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	atcagtccttgttcgacatcAgcgaattcatactggtgaga	9	9	3	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr19:37367974A>G	uc002oex.2	+	3	620	c.242A>G	c.(241-243)CAG>CGG	p.Q81R	ZNF345_uc002oey.3_Missense_Mutation_p.Q81R|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	81	C2H2-type 1.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTTCGACATCAGCGAATTCAT	0.398													G	37367974	G	G	37367974	3	3	279	1	0	0	0	0	1	0	0	0	17856	188	7	4	244	4	ZNF345	19	37367974	Missense_Mutation	SNP	A	TCGA-76-6663-01A-11D-1845-08	2135633	37367974	21761009	57	20095											
SLC17A7	57030	broad.mit.edu	37	chr19	49937876	49937876	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccacaaaaggctgtcgtcGccaggcgactccgttctaag	10	14	1	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr19:49937876G>A	uc002pnp.2	-	5	792	c.620C>T	c.(619-621)GCG>GTG	p.A207V	SLC17A7_uc002pnq.1_Missense_Mutation_p.A140V|SLC17A7_uc002pno.2_5'UTR	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	207	Cytoplasmic (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity	p.A207A(1)		ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GGCTGTCGTCGCCAGGCGACT	0.343													A	49937876	A	A	49937876	3	1	279	1	0	0	0	0	1	0	0	0	14422	1087	38	1	1094	1	SLC17A7	19	49937876	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	12569902	49937876	9191107	58	20096											
HNF4A	3172	broad.mit.edu	37	chr20	43034798	43034798	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cgggccacgggcaaacactaCggtgcctcgagctgtgacgg	15	13	0	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr20:43034798C>T	uc002xma.2	+	2	305	c.216C>T	c.(214-216)TAC>TAT	p.Y72Y	HNF4A_uc010zwo.1_Missense_Mutation_p.T63M|HNF4A_uc002xlt.2_Silent_p.Y50Y|HNF4A_uc002xlu.2_Silent_p.Y50Y|HNF4A_uc002xlv.2_Silent_p.Y50Y|HNF4A_uc002xly.2_Silent_p.Y72Y|HNF4A_uc002xlz.2_Silent_p.Y72Y|HNF4A_uc010ggq.2_Silent_p.Y65Y	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	72	Nuclear receptor.|NR C4-type.				blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GCAAACACTACGGTGCCTCGA	0.572													T	43034798	T	T	43034798	2	4	279	1	0	0	0	0	0	0	0	1	7253	547	19	1		1	HNF4A	20	43034798	Silent	SNP	C	TCGA-76-6663-01A-11D-1845-08		43034798	19990722	59	20097											
ABCG1	9619	broad.mit.edu	37	chr21	43716431	43716431	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acctggacttcatcgtactcGggattttcttcatctccctc	6	14	4	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr21:43716431G>A	uc002zaq.2	+	15	2072	c.1966G>A	c.(1966-1968)GGG>AGG	p.G656R	ABCG1_uc002zan.2_Missense_Mutation_p.G646R|ABCG1_uc002zam.2_Missense_Mutation_p.G622R|ABCG1_uc002zao.2_Missense_Mutation_p.G641R|ABCG1_uc002zap.2_Missense_Mutation_p.G644R|ABCG1_uc002zar.2_Missense_Mutation_p.G655R|ABCG1_uc011aev.1_Missense_Mutation_p.G667R|uc002zau.2_5'Flank	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	656	ABC transmembrane type-2.|Helical; (Potential).				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	CATCGTACTCGGGATTTTCTT	0.522													A	43716431	A	A	43716431	3	1	279	1	0	0	0	0	1	0	0	0	68	1116	39	2	2192	2	ABCG1	21	43716431	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08		43716431	4413464	60	20098											
HPS4	89781	broad.mit.edu	37	chr22	26860320	26860320	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcaggagcagagggagggcGcaagctgctgatggctgtgt	18	8	1	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr22:26860320G>A	uc003acl.2	-	11	1935	c.1276C>T	c.(1276-1278)CGC>TGC	p.R426C	HPS4_uc003aci.2_Missense_Mutation_p.R421C|HPS4_uc003acj.2_Missense_Mutation_p.R290C|HPS4_uc003ack.2_Missense_Mutation_p.R217C|HPS4_uc003acn.2_Missense_Mutation_p.R272C|HPS4_uc010gvd.1_Missense_Mutation_p.R444C|HPS4_uc003ach.2_Missense_Mutation_p.R161C	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	426					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						GAGGGAGGGCGCAAGCTGCTG	0.622									Hermansky-Pudlak_syndrome				A	26860320	A	A	26860320	3	1	279	1	0	0	0	0	1	0	0	0	7341	1087	38	1	866	1	HPS4	22	26860320	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08		26860320	24444246	61	20099											
PANX2	56666	broad.mit.edu	37	chr22	50617533	50617533	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcaccatcctgagccgaaacGccacacacccgctgctgcac	7	19	1	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chr22:50617533G>A	uc003bjn.3	+	3	1861	c.1861G>A	c.(1861-1863)GCC>ACC	p.A621T	PANX2_uc003bjp.3_Missense_Mutation_p.A487T|PANX2_uc003bjo.3_Missense_Mutation_p.A621T	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	621	Cytoplasmic (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		GAGCCGAAACGCCACACACCC	0.711													A	50617533	A	A	50617533	3	1	279	1	0	0	0	0	1	0	0	0	11421	1087	38	1	1871	1	PANX2	22	50617533	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	23757213	50617533	687033	62	20100											
MXRA5	25878	broad.mit.edu	37	chrX	3241682	3241682	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagagcctttgcacctgggcGtctgcctcttttggatggca	12	11	2	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:3241682G>A	uc004crg.3	-	5	2201	c.2044C>T	c.(2044-2046)CGC>TGC	p.R682C		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	682						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCACCTGGGCGTCTGCCTCTT	0.532													A	3241682	A	A	3241682	3	1	279	1	0	0	0	0	1	0	0	0	10003	1145	40	1	6454	1	MXRA5	23	3241682	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08		3241682	152028878	63	20101											
FRMPD4	9758	broad.mit.edu	37	chrX	12712508	12712508	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtcttttccgaattagcttcGtcccaaaagatccaattgac	6	11	1	2	rs148666498		TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:12712508G>A	uc004cuz.1	+	9	1374	c.868G>A	c.(868-870)GTC>ATC	p.V290I	FRMPD4_uc011mij.1_Missense_Mutation_p.V282I	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	290	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						AATTAGCTTCGTCCCAAAAGA	0.413													A	12712508	A	A	12712508	3	1	279	1	0	0	0	0	1	0	0	0	6059	1145	40	1	902	1	FRMPD4	23	12712508	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	9470826	12712508	142558052	64	20102											
YY2	404281	broad.mit.edu	37	chrX	21875300	21875300	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cattgatctctcagatcctaAacagctggcagaatttacta	6	10	2	3			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:21875300A>G	uc011mjp.1	+	1	698	c.698A>G	c.(697-699)AAA>AGA	p.K233R	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Missense_Mutation_p.K451R|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TCAGATCCTAAACAGCTGGCA	0.488													G	21875300	G	G	21875300	3	3	279	1	0	0	0	0	1	0	0	0	17506	14	1	4	700	4	YY2	23	21875300	Missense_Mutation	SNP	A	TCGA-76-6663-01A-11D-1845-08	9162792	21875300	133395260	65	20103											
MED12	9968	broad.mit.edu	37	chrX	70341522	70341523	+	Frame_Shift_Del	DEL	TA	-	-													agcagtcactcatctcatgtTatatctgctcagtcaacaag							TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:70341522_70341523delTA	uc004dyy.2	+	7	1156_1157	c.957_958delTA	c.(955-960)GTTATAfs	p.V319fs	MED12_uc011mpq.1_Frame_Shift_Del_p.V319fs|MED12_uc004dyz.2_Frame_Shift_Del_p.V319fs|MED12_uc004dza.2_Frame_Shift_Del_p.V166fs	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	319_320					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CATCTCATGTTATATCTGCTCA	0.554													-	70341523	-	-	70341522	7	5	279	1	0	1	0	1	0	0	0	0	9428	1741	61	0	983	0	MED12	23	70341522	Frame_Shift_Del	DEL	TA	TCGA-76-6663-01A-11D-1845-08	48466222	70341522	84929038	66	20104											
ACRC	93953	broad.mit.edu	37	chrX	70824283	70824283	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tcagcaaaccaccaagtgatCctgaggctaaccctgaagtt	8	12	1	3			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:70824283C>T	uc004eae.2	+	8	1657	c.1156C>T	c.(1156-1158)CCT>TCT	p.P386S	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	386						nucleus				ovary(3)	3	Renal(35;0.156)					ACCAAGTGATCCTGAGGCTAA	0.498													T	70824283	T	T	70824283	3	4	279	1	0	0	0	0	1	0	0	0	171	855	30	3	1182	3	ACRC	23	70824283	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	482761	70824283	84446277	67	20105											
DRP2	1821	broad.mit.edu	37	chrX	100490945	100490945	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	acgggtctgttggtgcctctGgacccctggaaccaccagcc	12	15	2	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:100490945G>C	uc004egz.2	+	4	583	c.214G>C	c.(214-216)GGA>CGA	p.G72R	DRP2_uc011mrh.1_5'UTR	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	72					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TGGTGCCTCTGGACCCCTGGA	0.522													C	100490945	C	C	100490945	3	2	279	1	0	0	0	0	1	0	0	0	4764	1349	47	5	220	5	DRP2	23	100490945	Missense_Mutation	SNP	G	TCGA-76-6663-01A-11D-1845-08	29666662	100490945	54779615	68	20106											
TBC1D8B	54885	broad.mit.edu	37	chrX	106066520	106066521	+	Frame_Shift_Del	DEL	AG	-	-													acttcaaatgtcatactgacAgagagtattcacgtgtgttc							TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:106066520_106066521delAG	uc004emo.2	+	5	816_817	c.651_652delAG	c.(649-654)ACAGAGfs	p.T217fs	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emm.2_Frame_Shift_Del_p.T217fs|TBC1D8B_uc004emn.2_Frame_Shift_Del_p.T217fs	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	217_218						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TCATACTGACAGAGAGTATTCA	0.361													-	106066521	-	-	106066520	7	5	279	1	0	1	0	1	0	0	0	0	15623	175	7	0	669	0	TBC1D8B	23	106066520	Frame_Shift_Del	DEL	AG	TCGA-76-6663-01A-11D-1845-08	5575575	106066520	49204040	69	20107											
MID2	11043	broad.mit.edu	37	chrX	107160962	107160962	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctcaagattggccggggcGccacgaggcaagtgtttgta	15	9	1	1			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:107160962G>A	uc004enl.2	+	7	2001	c.1428G>A	c.(1426-1428)GCG>GCA	p.A476A	MID2_uc004enk.2_Intron	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	476	Fibronectin type-III.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TGGCCGGGGCGCCACGAGGCA	0.483													A	107160962	A	A	107160962	2	1	279	1	0	0	0	0	0	0	0	1	9578	1074	38	1		1	MID2	23	107160962	Silent	SNP	G	TCGA-76-6663-01A-11D-1845-08	1094442	107160962	48109598	70	20108											
ZNF75D	7626	broad.mit.edu	37	chrX	134428042	134428042	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgggggcttgagcatgaatCcgcgttcagctctctcatcg	12	12	3	2			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:134428042C>T	uc004eyp.2	-	3	2680	c.25G>A	c.(25-27)GAT>AAT	p.D9N	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'Flank|ZNF75D_uc004eyo.2_Missense_Mutation_p.D9N	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	9					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAGCATGAATCCGCGTTCAGC	0.478													T	134428042	T	T	134428042	3	4	279	1	0	0	0	0	1	0	0	0	18131	855	30	3	1527	3	ZNF75D	23	134428042	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	27267080	134428042	20842518	71	20109											
PDZD4	57595	broad.mit.edu	37	chrX	153069697	153069697	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gggtgctgcggcagctctccCcagtgttgtaggcgctggtg	17	11	1	0			TCGA-76-6663-01A-11D-1845-08	TCGA-76-6663-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	624864ad-3178-4a6d-a0cf-7fa3e9bdf8da	f0474e2a-120a-4bab-ad7e-cc23f09db238	g.chrX:153069697C>G	uc004fiz.1	-	8	1671	c.1421G>C	c.(1420-1422)GGG>GCG	p.G474A	PDZD4_uc004fiy.1_Missense_Mutation_p.G399A|PDZD4_uc004fix.2_Missense_Mutation_p.G378A|PDZD4_uc004fja.1_Missense_Mutation_p.G480A|PDZD4_uc011mze.1_Missense_Mutation_p.G365A	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	474						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCAGCTCTCCCCAGTGTTGTA	0.682													G	153069697	G	G	153069697	3	3	279	1	0	0	0	0	1	0	0	0	11703	623	22	5	892	5	PDZD4	23	153069697	Missense_Mutation	SNP	C	TCGA-76-6663-01A-11D-1845-08	18641655	153069697	2200863	72	20110											
PRAMEF11	440560	broad.mit.edu	37	chr1	12887475	12887475	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	cctctgcttgacccatagaaGgaggcaggtgaggtattcat	12	9	2	3			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr1:12887475G>T	uc001auk.2	-	3	578	c.382C>A	c.(382-384)CTT>ATT	p.L128I		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	128											0						ACCCATAGAAGGAGGCAGGTG	0.468													T	12887475	T	T	12887475	3	4	280	1	0	0	0	0	1	0	0	0	12427	1000	35	5	936	5	PRAMEF11	1	12887475	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08		12887475	236363146	1	20111											
B4GALT2	8704	broad.mit.edu	37	chr1	44446914	44446914	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgctgcacttcctcgtggccGtcatcctctactttgacgtc	8	15	2	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr1:44446914G>A	uc001clg.2	+	2	452	c.82G>A	c.(82-84)GTC>ATC	p.V28I	B4GALT2_uc001clh.2_5'UTR|B4GALT2_uc010okl.1_Missense_Mutation_p.V57I|B4GALT2_uc001cli.2_Missense_Mutation_p.V28I	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	28	Helical; Signal-anchor for type II membrane protein; (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	CCTCGTGGCCGTCATCCTCTA	0.637													A	44446914	A	A	44446914	3	1	280	1	0	0	0	0	1	0	0	0	1271	1145	40	1	84	1	B4GALT2	1	44446914	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	31559439	44446914	204803707	2	20112											
PPM1J	333926	broad.mit.edu	37	chr1	113255057	113255057	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cctccacttggtggccacgcCgctcccgggccatctgctca	10	19	2	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr1:113255057C>T	uc001ect.1	-	4	779	c.752G>A	c.(751-753)CGG>CAG	p.R251Q	PPM1J_uc009wgl.1_RNA|PPM1J_uc001ecs.1_Missense_Mutation_p.R45Q	NM_005167	NP_005158	Q5JR12	PPM1J_HUMAN	protein phosphatase 1J (PP2C domain containing)	251	PP2C-like.									breast(2)|central_nervous_system(1)	3	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGGCCACGCCGCTCCCGGGC	0.617													T	113255057	T	T	113255057	3	4	280	1	0	0	0	0	1	0	0	0	12342	652	23	2	793	2	PPM1J	1	113255057	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	68808143	113255057	135995564	3	20113											
KCNK3	3777	broad.mit.edu	37	chr2	26950539	26950539	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcccactttcccccaggctaCgggcacgcggcacccagcac	9	20	0	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr2:26950539C>T	uc002rhn.2	+	2	451	c.288C>T	c.(286-288)TAC>TAT	p.Y96Y		NM_002246	NP_002237	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	96					synaptic transmission	integral to plasma membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCAGGCTACGGGCACGCGG	0.632													T	26950539	T	T	26950539	2	4	280	1	0	0	0	0	0	0	0	1	8067	547	19	1		1	KCNK3	2	26950539	Silent	SNP	C	TCGA-76-6664-01A-11D-1845-08		26950539	216248834	4	20114											
DDX18	8886	broad.mit.edu	37	chr2	118587017	118587017	+	Missense_Mutation	SNP	C	A	A	0	1	1	0	1	0	0	0	0	0	0	0	gttgctctgtcatttggtttCaaggtgcctcccttcgttga	10	10	3	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr2:118587017C>A	uc002tlh.1	+	13	1944	c.1845C>A	c.(1843-1845)TTC>TTA	p.F615L		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	615							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						CATTTGGTTTCAAGGTGCCTC	0.398													A	118587017	A	A	118587017	3	1	280	1	0	0	0	0	1	0	0	0	4345	825	29	5	1895	5	DDX18	2	118587017	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	91636478	118587017	124612356	5	20115											
UBP1	7342	broad.mit.edu	37	chr3	33454282	33454282	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gttgctgatgctctgtgtatTgtagccgtctgtcatggaat	12	7	3	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr3:33454282T>C	uc003cfq.3	-	4	910	c.380A>G	c.(379-381)CAA>CGA	p.Q127R	UBP1_uc003cfr.3_Missense_Mutation_p.Q127R|UBP1_uc010hga.2_Missense_Mutation_p.Q127R	NM_014517	NP_055332	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a) isoform a	127					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			kidney(2)	2						CTCTGTGTATTGTAGCCGTCT	0.438													C	33454282	C	C	33454282	3	2	280	1	0	0	0	0	1	0	0	0	16892	1812	63	4	1294	4	UBP1	3	33454282	Missense_Mutation	SNP	T	TCGA-76-6664-01A-11D-1845-08		33454282	164568148	6	20116											
TMF1	7110	broad.mit.edu	37	chr3	69097485	69097485	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttttcacttcttcttctggtCgttgtgattttgctggaggt	10	7	4	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr3:69097485C>T	uc003dnn.2	-	2	618	c.371G>A	c.(370-372)CGA>CAA	p.R124Q	TMF1_uc011bfx.1_Missense_Mutation_p.R124Q	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	124					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		TTCTTCTGGTCGTTGTGATTT	0.418													T	69097485	T	T	69097485	3	4	280	1	0	0	0	0	1	0	0	0	16225	884	31	2	2974	2	TMF1	3	69097485	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	35643203	69097485	128924945	7	20117											
IQCG	84223	broad.mit.edu	37	chr3	197616555	197616555	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gaaaccaccaatttctctccGtatcatagtgcctcgccacc	5	16	2	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr3:197616555G>A	uc003fyo.2	-	11	1374	c.1228C>T	c.(1228-1230)CGG>TGG	p.R410W	IQCG_uc003fyn.2_Missense_Mutation_p.R312W|IQCG_uc003fyp.2_Missense_Mutation_p.R410W|IQCG_uc003fym.2_Missense_Mutation_p.R111W	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	410	IQ.										0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		ATTTCTCTCCGTATCATAGTG	0.463													A	197616555	A	A	197616555	3	1	280	1	0	0	0	0	1	0	0	0	7810	1144	40	1	107	1	IQCG	3	197616555	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	128519070	197616555	405875	8	20118											
NPFFR2	10886	broad.mit.edu	37	chr4	72897628	72897628	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	cttagcgggatatgaatagcTtcttcggaaccccagcggcc	11	12	1	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr4:72897628T>A	uc003hgg.2	+	1	108	c.10T>A	c.(10-12)TTC>ATC	p.F4I	NPFFR2_uc010iig.1_5'UTR	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	4	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TATGAATAGCTTCTTCGGAAC	0.562													A	72897628	A	A	72897628	3	1	280	1	0	0	0	0	1	0	0	0	10578	1609	56	5	12	5	NPFFR2	4	72897628	Missense_Mutation	SNP	T	TCGA-76-6664-01A-11D-1845-08		72897628	118256648	9	20119											
ROPN1L	83853	broad.mit.edu	37	chr5	10461398	10461398	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cgttttcctacgtttaccgcTacttggccagattagactca	7	12	1	2			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr5:10461398T>G	uc003jex.3	+	4	791	c.520T>G	c.(520-522)TAC>GAC	p.Y174D		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	174					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			ovary(1)	1						CGTTTACCGCTACTTGGCCAG	0.527													G	10461398	G	G	10461398	3	3	280	1	0	0	0	0	1	0	0	0	13525	1522	53	5	534	5	ROPN1L	5	10461398	Missense_Mutation	SNP	T	TCGA-76-6664-01A-11D-1845-08		10461398	170453862	10	20120											
VCAN	1462	broad.mit.edu	37	chr5	82816676	82816676	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caagtttcactgaagatggaGcagatgaatttactcttatt	8	6	2	4			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr5:82816676G>A	uc003kii.3	+	7	2907	c.2551G>A	c.(2551-2553)GCA>ACA	p.A851T	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.A851T|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	851	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TGAAGATGGAGCAGATGAATT	0.408													A	82816676	A	A	82816676	3	1	280	1	0	0	0	0	1	0	0	0	17135	971	34	3	2573	3	VCAN	5	82816676	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	72355278	82816676	98098584	11	20121											
ADAMTS2	9509	broad.mit.edu	37	chr5	178555036	178555036	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acagagtcctcttccaggacGttgttgtcgtcgacattcag	10	11	2	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr5:178555036G>A	uc003mjw.2	-	17	2541	c.2541C>T	c.(2539-2541)AAC>AAT	p.N847N		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	847	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CTTCCAGGACGTTGTTGTCGT	0.587													A	178555036	A	A	178555036	2	1	280	1	0	0	0	0	0	0	0	1	265	1136	40	1		1	ADAMTS2	5	178555036	Silent	SNP	G	TCGA-76-6664-01A-11D-1845-08	95738360	178555036	2360224	12	20122											
OR2B6	26212	broad.mit.edu	37	chr6	27925491	27925491	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggttttagtaactcagtgtGgttgtctaccctgactctcc	9	10	3	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr6:27925491G>T	uc011dkx.1	+	1	473	c.473G>T	c.(472-474)TGG>TTG	p.W158L		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AACTCAGTGTGGTTGTCTACC	0.493													T	27925491	T	T	27925491	3	4	280	1	0	0	0	0	1	0	0	0	10991	1357	47	5	475	5	OR2B6	6	27925491	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08		27925491	143189576	13	20123											
APOBEC2	10930	broad.mit.edu	37	chr6	41029317	41029317	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ggtatgtgtcctccagccccTgtgcagcgtgtgctgaccgc	13	14	0	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr6:41029317T>C	uc003opl.2	+	2	529	c.382T>C	c.(382-384)TGT>CGT	p.C128R	UNC5CL_uc010jxe.1_Intron|APOBEC2_uc010jxf.2_RNA	NM_006789	NP_006780	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	128		Zinc; catalytic.			DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTCCAGCCCCTGTGCAGCGTG	0.572													C	41029317	C	C	41029317	3	2	280	1	0	0	0	0	1	0	0	0	788	1580	55	4	388	4	APOBEC2	6	41029317	Missense_Mutation	SNP	T	TCGA-76-6664-01A-11D-1845-08	13103826	41029317	130085750	14	20124											
PNLDC1	154197	broad.mit.edu	37	chr6	160240043	160240043	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atcctcagcgtcaaaaggtgGcctggggtcagcgagcagca	14	11	3	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr6:160240043G>A	uc003qsx.1	+	17	1461	c.1290G>A	c.(1288-1290)TGG>TGA	p.W430*	PNLDC1_uc003qsy.1_Nonsense_Mutation_p.W441*	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	430	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TCAAAAGGTGGCCTGGGGTCA	0.463													A	160240043	A	A	160240043	4	1	280	1	0	0	0	0	0	1	0	0	12148	1212	42	3	1352	3	PNLDC1	6	160240043	Nonsense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	119210726	160240043	10875024	15	20125											
PRPS1L1	221823	broad.mit.edu	37	chr7	18066638	18066638	+	Silent	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtgttgatgcgagaaatggcTgggccagaaaagattccatg	14	6	0	4			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr7:18066638T>A	uc003stz.2	-	1	849	c.768A>T	c.(766-768)CCA>CCT	p.P256P		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	256					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					GAGAAATGGCTGGGCCAGAAA	0.448													A	18066638	A	A	18066638	2	1	280	1	0	0	0	0	0	0	0	1	12579	1567	55	5		5	PRPS1L1	7	18066638	Silent	SNP	T	TCGA-76-6664-01A-11D-1845-08		18066638	141072025	16	20126											
SAMD9	54809	broad.mit.edu	37	chr7	92730646	92730646	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	aagaatatcaggctcttaaaCaatttcaatgtcataagcaa	5	7	4	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr7:92730646C>G	uc003umf.2	-	3	5021	c.4765G>C	c.(4765-4767)GTT>CTT	p.V1589L	SAMD9_uc003umg.2_Missense_Mutation_p.V1589L	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1589						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GGCTCTTAAACAATTTCAATG	0.378													G	92730646	G	G	92730646	3	3	280	1	0	0	0	0	1	0	0	0	13826	478	17	5	8	5	SAMD9	7	92730646	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	74664008	92730646	66408017	17	20127											
EGR3	1960	broad.mit.edu	37	chr8	22550311	22550311	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccgccgcccttacctgtagcCatctgattgtaatggactac	8	14	1	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr8:22550311C>T	uc003xcm.1	-	1	505	c.147G>A	c.(145-147)ATG>ATA	p.M49I	EGR3_uc011kzn.1_5'Flank|EGR3_uc011kzo.1_5'Flank	NM_004430	NP_004421	Q06889	EGR3_HUMAN	early growth response 3	49					circadian rhythm|muscle organ development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)		Colorectal(74;0.0145)|BRCA - Breast invasive adenocarcinoma(99;0.053)|COAD - Colon adenocarcinoma(73;0.0608)		TACCTGTAGCCATCTGATTGT	0.338													T	22550311	T	T	22550311	3	4	280	1	0	0	0	0	1	0	0	0	4973	594	21	3	1024	3	EGR3	8	22550311	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08		22550311	123813711	18	20128											
CNGB3	54714	broad.mit.edu	37	chr8	87666239	87666239	+	Splice_Site	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttgaaattgtttgtcacctaCctgaaattttgtagaagtcc	7	7	1	3			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr8:87666239C>T	uc003ydx.2	-	7	949	c.903_splice	c.e7+1	p.Q301_splice	CNGB3_uc010maj.2_Splice_Site_p.Q163_splice	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3						signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TTGTCACCTACCTGAAATTTT	0.294													T	87666239	T	T	87666239	5	4	280	1	0	0	0	0	0	0	1	0	3601	521	18	3	1573	3	CNGB3	8	87666239	Splice_Site	SNP	C	TCGA-76-6664-01A-11D-1845-08	65115928	87666239	58697783	19	20129											
RGS22	26166	broad.mit.edu	37	chr8	101065160	101065160	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agaatttcagttcagcactaGcatattttgttgaggctgaa	9	6	2	3			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr8:101065160G>A	uc003yjb.1	-	10	1754	c.1559C>T	c.(1558-1560)GCT>GTT	p.A520V	RGS22_uc003yja.1_Missense_Mutation_p.A339V|RGS22_uc003yjc.1_Missense_Mutation_p.A508V|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	520					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TTCAGCACTAGCATATTTTGT	0.393													A	101065160	A	A	101065160	3	1	280	1	0	0	0	0	1	0	0	0	13305	971	34	3	2307	3	RGS22	8	101065160	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	13398921	101065160	45298862	20	20130											
DMRT3	58524	broad.mit.edu	37	chr9	990870	990870	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgcccgtccttcctgcccgCgccacggaagaccctcggat	10	19	0	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr9:990870C>T	uc003zgw.1	+	2	1322	c.1284C>T	c.(1282-1284)CGC>CGT	p.R428R		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	428					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity	p.R428C(1)		ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		TTCCTGCCCGCGCCACGGAAG	0.552													T	990870	T	T	990870	2	4	280	1	0	0	0	0	0	0	0	1	4587	755	27	1		1	DMRT3	9	990870	Silent	SNP	C	TCGA-76-6664-01A-11D-1845-08		990870	140222561	21	20131											
GAPVD1	26130	broad.mit.edu	37	chr9	128092422	128092422	+	Missense_Mutation	SNP	G	A	A	1	0	0	1	0	1	1	0	1	1	0	1	gttcagggtcagtgcttcttGacccctgcactggttctacc	10	13	4	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr9:128092422G>A	uc010mwx.2	+	13	2424	c.2098G>A	c.(2098-2100)GAC>AAC	p.D700N	GAPVD1_uc011lzs.1_Missense_Mutation_p.D700N|GAPVD1_uc004bpp.2_Missense_Mutation_p.D700N|GAPVD1_uc004bpq.2_Missense_Mutation_p.D700N|GAPVD1_uc004bpr.2_Missense_Mutation_p.D679N|GAPVD1_uc004bps.2_Missense_Mutation_p.D700N|GAPVD1_uc010mwy.1_Missense_Mutation_p.D559N	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	700					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AGTGCTTCTTGACCCCTGCAC	0.478													A	128092422	A	A	128092422	3	1	280	1	0	0	0	0	1	0	0	0	6239	1290	45	3	2136	3	GAPVD1	9	128092422	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	127101552	128092422	13121009	22	20132											
PTEN	5728	broad.mit.edu	37	chr10	89692768	89692768	+	Splice_Site	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgaggttatctttttaccacAgttgcacaatatccttttga	6	8	1	2			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr10:89692768A>C	uc001kfb.2	+	6	1285	c.254_splice	c.e6-2	p.V85_splice		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.C71fs*6(2)|p.Y27fs*1(2)|p.N82_P95del(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTTTTACCACAGTTGCACAAT	0.328		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			C	89692768	C	C	89692768	5	2	280	1	0	0	0	0	0	0	1	0	12738	202	7	5	270	5	PTEN	10	89692768	Splice_Site	SNP	A	TCGA-76-6664-01A-11D-1845-08		89692768	45841979	23	20133											
FAM181B	220382	broad.mit.edu	37	chr11	82443599	82443599	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccgcgctgtaatcgtaggaCacctgatggggcggcggcgg	17	12	0	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr11:82443599C>T	uc001ozp.2	-	1	1308	c.1173G>A	c.(1171-1173)GTG>GTA	p.V391V		NM_175885	NP_787081	A6NEQ2	F181B_HUMAN	hypothetical protein LOC220382	391										large_intestine(1)	1						AATCGTAGGACACCTGATGGG	0.706													T	82443599	T	T	82443599	2	4	280	1	0	0	0	0	0	0	0	1	5509	465	17	3		3	FAM181B	11	82443599	Silent	SNP	C	TCGA-76-6664-01A-11D-1845-08		82443599	52562917	24	20134											
NOX4	50507	broad.mit.edu	37	chr11	89073229	89073229	+	Splice_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	ctagaaccaaccctaatgttAccttgttatgcaacatacag	5	11	0	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr11:89073229A>T	uc001pct.2	-	15	1685	c.1446_splice	c.e15+1	p.K482_splice	NOX4_uc009yvr.2_Splice_Site_p.K457_splice|NOX4_uc001pcu.2_Splice_Site_p.K408_splice|NOX4_uc001pcw.2_Splice_Site_p.K175_splice|NOX4_uc001pcx.2_Splice_Site_p.K135_splice|NOX4_uc001pcv.2_Splice_Site_p.K442_splice|NOX4_uc009yvo.2_Splice_Site|NOX4_uc010rtu.1_Intron|NOX4_uc009yvp.2_Splice_Site_p.K246_splice|NOX4_uc010rtv.1_Splice_Site_p.K418_splice|NOX4_uc009yvq.2_Splice_Site_p.K458_splice	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CCCTAATGTTACCTTGTTATG	0.318													T	89073229	T	T	89073229	5	4	280	1	0	0	0	0	0	0	1	0	10558	405	14	5	304	5	NOX4	11	89073229	Splice_Site	SNP	A	TCGA-76-6664-01A-11D-1845-08	6629630	89073229	45933287	25	20135											
ANGPTL5	253935	broad.mit.edu	37	chr11	101762058	101762058	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ctaattttcattgaaacagaTttaatcttgacaggtgagtt	7	5	2	4			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr11:101762058T>A	uc001pgl.2	-	9	1715	c.1119A>T	c.(1117-1119)AAA>AAT	p.K373N		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	373	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		TTGAAACAGATTTAATCTTGA	0.303													A	101762058	A	A	101762058	3	1	280	1	0	0	0	0	1	0	0	0	617	1490	52	5	51	5	ANGPTL5	11	101762058	Missense_Mutation	SNP	T	TCGA-76-6664-01A-11D-1845-08	12688829	101762058	33244458	26	20136											
MMP1	4312	broad.mit.edu	37	chr11	102663372	102663372	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ttcatctctgtcggcaaattCgtaagcagcttcaagcccat	7	12	3	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr11:102663372C>T	uc001phi.2	-	7	1140	c.997G>A	c.(997-999)GAA>AAA	p.E333K	uc001phh.1_Intron|MMP1_uc010ruv.1_Missense_Mutation_p.E267K	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	333	Hemopexin-like 2.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		TCGGCAAATTCGTAAGCAGCT	0.403													T	102663372	T	T	102663372	3	4	280	1	0	0	0	0	1	0	0	0	9648	893	31	2	428	2	MMP1	11	102663372	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	901314	102663372	32343144	27	20137											
IPO8	10526	broad.mit.edu	37	chr12	30809654	30809654	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cagaacaagatcaatgatccGtagacagatattctctaact	6	9	2	5			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr12:30809654G>A	uc001rjd.2	-	17	2082	c.1912C>T	c.(1912-1914)CGG>TGG	p.R638W	IPO8_uc001rje.1_Missense_Mutation_p.R127W|IPO8_uc010sjt.1_Missense_Mutation_p.R433W	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	638					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TCAATGATCCGTAGACAGATA	0.199													A	30809654	A	A	30809654	3	1	280	1	0	0	0	0	1	0	0	0	7798	1144	40	1	1237	1	IPO8	12	30809654	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08		30809654	103042241	28	20138											
ZBTB39	9880	broad.mit.edu	37	chr12	57396685	57396685	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	atgtttgctcatgaggttaaGggtggaactgtagtgcccac	13	7	1	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr12:57396685G>T	uc001sml.1	-	2	2103	c.2017C>A	c.(2017-2019)CTT>ATT	p.L673I	RDH16_uc010sqx.1_RNA	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	673	C2H2-type 8; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						ATGAGGTTAAGGGTGGAACTG	0.542													T	57396685	T	T	57396685	3	4	280	1	0	0	0	0	1	0	0	0	17537	1000	35	5	125	5	ZBTB39	12	57396685	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	26587031	57396685	76455210	29	20139											
STARD13	90627	broad.mit.edu	37	chr13	33685935	33685935	+	Nonsense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	ctcaaaaagtctgtcgcattCcatgatcatgtgcgctagcc	8	12	3	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr13:33685935C>A	uc001uuw.2	-	10	2713	c.2587G>T	c.(2587-2589)GAA>TAA	p.E863*	STARD13_uc001uuu.2_Nonsense_Mutation_p.E855*|STARD13_uc001uuv.2_Nonsense_Mutation_p.E745*|STARD13_uc001uux.2_Nonsense_Mutation_p.E828*|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	863	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		CTGTCGCATTCCATGATCATG	0.478													A	33685935	A	A	33685935	4	1	280	1	0	0	0	0	0	1	0	0	15255	864	30	5	774	5	STARD13	13	33685935	Nonsense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08		33685935	81483943	30	20140											
SLC15A1	6564	broad.mit.edu	37	chr13	99337143	99337143	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acacagacgaccagaagcaaCgcggcaaatagaatgtactc	9	11	0	3	rs143994270	by1000genomes	TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr13:99337143C>T	uc001vno.2	-	23	2039	c.1962G>A	c.(1960-1962)GCG>GCA	p.A654A		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	654	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CCAGAAGCAACGCGGCAAATA	0.418													T	99337143	T	T	99337143	2	4	280	1	0	0	0	0	0	0	0	1	14398	523	19	1		1	SLC15A1	13	99337143	Silent	SNP	C	TCGA-76-6664-01A-11D-1845-08	65651208	99337143	15832735	31	20141											
ASB2	51676	broad.mit.edu	37	chr14	94419793	94419793	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtccaggtggcccctgcacGttgccaagtaaacggctgtt	12	12	0	0	rs113529772		TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr14:94419793G>A	uc001ycc.1	-	3	884	c.395C>T	c.(394-396)ACG>ATG	p.T132M	ASB2_uc001ycd.2_Missense_Mutation_p.T180M|ASB2_uc001yce.1_Missense_Mutation_p.T78M	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	132	ANK 3.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		GCCCCTGCACGTTGCCAAGTA	0.587													A	94419793	A	A	94419793	3	1	280	1	0	0	0	0	1	0	0	0	1023	1145	40	1	1392	1	ASB2	14	94419793	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08		94419793	12929747	32	20142											
JAG2	3714	broad.mit.edu	37	chr14	105622189	105622189	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagaacttgttgcaagtggCgctgtagtagttctcgtcgc	13	9	1	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr14:105622189C>T	uc001yqg.2	-	4	1017	c.613G>A	c.(613-615)GCC>ACC	p.A205T	JAG2_uc001yqh.2_Missense_Mutation_p.A205T	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	205	DSL.|Extracellular (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TTGCAAGTGGCGCTGTAGTAG	0.627													T	105622189	T	T	105622189	3	4	280	1	0	0	0	0	1	0	0	0	7935	768	27	1	3195	1	JAG2	14	105622189	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	11202396	105622189	1727351	33	20143											
AQR	9716	broad.mit.edu	37	chr15	35193048	35193048	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cagtattcatcaggttccgaAtagtctccagcacagcctgt	8	12	3	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr15:35193048A>G	uc001ziv.2	-	20	2199	c.2018T>C	c.(2017-2019)ATT>ACT	p.I673T		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	673						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		CAGGTTCCGAATAGTCTCCAG	0.448													G	35193048	G	G	35193048	3	3	280	1	0	0	0	0	1	0	0	0	835	101	4	4	2503	4	AQR	15	35193048	Missense_Mutation	SNP	A	TCGA-76-6664-01A-11D-1845-08		35193048	67338344	34	20144											
THBS1	7057	broad.mit.edu	37	chr15	39879564	39879564	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcagccagcgactctgcggaCgatggctggtctccatggtc	14	13	2	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr15:39879564C>T	uc001zkh.2	+	8	1316	c.1137C>T	c.(1135-1137)GAC>GAT	p.D379D	THBS1_uc010bbi.2_5'Flank	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	379	TSP type-1 1.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	ACTCTGCGGACGATGGCTGGT	0.567													T	39879564	T	T	39879564	2	4	280	1	0	0	0	0	0	0	0	1	15850	535	19	1		1	THBS1	15	39879564	Silent	SNP	C	TCGA-76-6664-01A-11D-1845-08	4686516	39879564	62651828	35	20145											
SPTBN5	51332	broad.mit.edu	37	chr15	42164092	42164092	+	Frame_Shift_Del	DEL	A	-	-													tcaggaactcatgcagcctcAgggtcccctccagttcccgg							TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr15:42164092delA	uc001zos.2	-	28	5417	c.5084delT	c.(5083-5085)CTGfs	p.L1695fs		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1730	Spectrin 14.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		ATGCAGCCTCAGGGTCCCCTC	0.677													-	42164092	-	-	42164092	7	5	280	1	0	1	0	1	0	0	0	0	15121	188	7	0	5999	0	SPTBN5	15	42164092	Frame_Shift_Del	DEL	A	TCGA-76-6664-01A-11D-1845-08	2284528	42164092	60367300	36	20146											
ITFG3	83986	broad.mit.edu	37	chr16	315018	315018	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcggtaccagagtgaggcGtagaggcacgccagccagag	16	11	0	4			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr16:315018G>A	uc002cgf.2	+	13	1851	c.1656G>A	c.(1654-1656)GCG>GCA	p.A552A	ITFG3_uc002cgg.2_Intron|ITFG3_uc010uud.1_Intron|ITFG3_uc002cgh.2_Silent_p.A552A	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	552	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				AGAGTGAGGCGTAGAGGCACG	0.647													A	315018	A	A	315018	2	1	280	1	0	0	0	0	0	0	0	1	7871	1132	40	1		1	ITFG3	16	315018	Silent	SNP	G	TCGA-76-6664-01A-11D-1845-08		315018	90039735	37	20147											
PTX4	390667	broad.mit.edu	37	chr16	1537647	1537647	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggacgaggccctccaggcGtgccagtgagtcctgcaggg	17	12	0	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr16:1537647G>A	uc010uvf.1	-	2	451	c.451C>T	c.(451-453)CGC>TGC	p.R151C		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	156						extracellular region	metal ion binding				0						CCCTCCAGGCGTGCCAGTGAG	0.741													A	1537647	A	A	1537647	3	1	280	1	0	0	0	0	1	0	0	0	12823	1145	40	1	977	1	PTX4	16	1537647	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	1222629	1537647	88817106	38	20148											
CIITA	4261	broad.mit.edu	37	chr16	10997663	10997663	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcccaacatctccagaccGgccaggctccaccagcccct	6	22	1	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr16:10997663G>A	uc002dai.3	+	9	981	c.848G>A	c.(847-849)CGG>CAG	p.R283Q	CIITA_uc002daj.3_Missense_Mutation_p.R284Q|CIITA_uc002dak.3_Missense_Mutation_p.R234Q|CIITA_uc002dag.2_Missense_Mutation_p.R283Q|CIITA_uc002dah.2_Missense_Mutation_p.R235Q|CIITA_uc010bup.1_Missense_Mutation_p.R283Q	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	283					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						TCTCCAGACCGGCCAGGCTCC	0.627			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								A	10997663	A	A	10997663	3	1	280	1	0	0	0	0	1	0	0	0	3428	1116	39	2	882	2	CIITA	16	10997663	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	9460016	10997663	79357090	39	20149											
ERN2	10595	broad.mit.edu	37	chr16	23718095	23718095	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgttcggccaatgtagaggCggggggtggagggaccctct	19	8	1	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr16:23718095C>T	uc002dma.3	-	6	780	c.611G>A	c.(610-612)CGC>CAC	p.R204H	ERN2_uc010bxp.2_Missense_Mutation_p.R204H|ERN2_uc010bxq.1_Missense_Mutation_p.R12H	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	156	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AATGTAGAGGCGGGGGGTGGA	0.607													T	23718095	T	T	23718095	3	4	280	1	0	0	0	0	1	0	0	0	5238	768	27	1	2381	1	ERN2	16	23718095	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	12720432	23718095	66636658	40	20150											
C16orf82	162083	broad.mit.edu	37	chr16	27078770	27078770	+	Frame_Shift_Del	DEL	G	-	-													acagcaccaagcagactggaGggaaagagtgaggccagcct							TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr16:27078770delG	uc010vcm.1	+	1	552	c.454delG	c.(454-456)GGGfs	p.G152fs		NM_001145545	NP_001139017	Q7Z2V1	TNT_HUMAN	hypothetical protein LOC162083	215											0						GCAGACTGGAGGGAAAGAGTG	0.652													-	27078770	-	-	27078770	7	5	280	1	0	1	0	1	0	0	0	0	1838	1000	35	0	456	0	C16orf82	16	27078770	Frame_Shift_Del	DEL	G	TCGA-76-6664-01A-11D-1845-08	3360675	27078770	63275983	41	20151											
PHF23	79142	broad.mit.edu	37	chr17	7139423	7139423	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agcctcagggggtgttggcaGcacagggactggggcttcac	17	10	2	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr17:7139423G>A	uc002gfa.2	-	4	1050	c.823C>T	c.(823-825)CTG>TTG	p.L275L	DVL2_uc002gez.1_5'Flank|DVL2_uc010vtr.1_5'Flank|DVL2_uc010clz.1_5'Flank|PHF23_uc010vtt.1_Silent_p.L208L|PHF23_uc010cma.2_Silent_p.L145L	NM_024297	NP_077273	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	275							zinc ion binding				0						GGTGTTGGCAGCACAGGGACT	0.488													A	7139423	A	A	7139423	2	1	280	1	0	0	0	0	0	0	0	1	11835	962	34	3		3	PHF23	17	7139423	Silent	SNP	G	TCGA-76-6664-01A-11D-1845-08		7139423	74055787	42	20152											
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	16	11	1	1	rs121912651		TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			A	7577539	A	A	7577539	3	1	280	1	0	0	0	0	1	0	0	0	16378	1115	39	2	548	2	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	438116	7577539	73617671	43	20153											
MYH1	4619	broad.mit.edu	37	chr17	10398535	10398535	+	Missense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	gatggccttcttggccttctCttctgcattgcgggcttcct	10	13	3	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr17:10398535C>G	uc002gmo.2	-	36	5363	c.5269G>C	c.(5269-5271)GAG>CAG	p.E1757Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1757	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TTGGCCTTCTCTTCTGCATTG	0.473													G	10398535	G	G	10398535	3	3	280	1	0	0	0	0	1	0	0	0	10029	922	32	5	570	5	MYH1	17	10398535	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	2820996	10398535	70796675	44	20154											
KRT14	3861	broad.mit.edu	37	chr17	39742796	39742796	+	Silent	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	aagccaccaccaaagccaccAcccaagccagcaccaaggcc	6	20	0	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr17:39742796A>C	uc002hxf.1	-	1	352	c.291T>G	c.(289-291)GGT>GGG	p.G97G	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Silent_p.G97G	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	97	Head.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				caaagccaccacccaagccag	0.353													C	39742796	C	C	39742796	2	2	280	1	0	0	0	0	0	0	0	1	8451	146	6	5		5	KRT14	17	39742796	Silent	SNP	A	TCGA-76-6664-01A-11D-1845-08	29344261	39742796	41452414	45	20155											
MIER2	54531	broad.mit.edu	37	chr19	313632	313632	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gtcccagagcagctggtcttCgttctcgtagactgcacaag	11	12	2	2			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr19:313632C>T	uc002lok.1	-	8	676	c.667G>A	c.(667-669)GAA>AAA	p.E223K		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	223	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTGGTCTTCGTTCTCGTAG	0.622													T	313632	T	T	313632	3	4	280	1	0	0	0	0	1	0	0	0	9581	893	31	2	998	2	MIER2	19	313632	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08		313632	58815351	46	20156											
TUBB4	10382	broad.mit.edu	37	chr19	6495601	6495601	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagcggccgtggcgcgggtcGcacgccgccatcatgttctt	14	14	2	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr19:6495601G>A	uc002mfg.1	-	4	1016	c.909C>T	c.(907-909)TGC>TGT	p.C303C	TUBB4_uc002mff.1_Silent_p.C231C|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	303					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		GGCGCGGGTCGCACGCCGCCA	0.677													A	6495601	A	A	6495601	2	1	280	1	0	0	0	0	0	0	0	1	16755	1079	38	1		1	TUBB4	19	6495601	Silent	SNP	G	TCGA-76-6664-01A-11D-1845-08	6181969	6495601	52633382	47	20157											
MUC16	94025	broad.mit.edu	37	chr19	9089511	9089511	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agggtcatggaggaaagaacGgctgagctgggctttgtctt	16	6	2	2			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr19:9089511G>A	uc002mkp.2	-	1	2508	c.2304C>T	c.(2302-2304)GCC>GCT	p.A768A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	768	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGAAAGAACGGCTGAGCTGG	0.483													A	9089511	A	A	9089511	2	1	280	1	0	0	0	0	0	0	0	1	9973	1103	39	2		2	MUC16	19	9089511	Silent	SNP	G	TCGA-76-6664-01A-11D-1845-08	2593910	9089511	50039472	48	20158											
DCAF15	90379	broad.mit.edu	37	chr19	14071180	14071180	+	Silent	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	acagtcagtgtaggcgacctGactgaggtcaaagggcagac	14	9	2	3			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr19:14071180G>C	uc002mxt.2	+	11	1614	c.1608G>C	c.(1606-1608)CTG>CTC	p.L536L	DCAF15_uc002mxu.2_RNA	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	536										central_nervous_system(1)	1						TAGGCGACCTGACTGAGGTCA	0.637											OREG0025301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	C	14071180	C	C	14071180	2	2	280	1	0	0	0	0	0	0	0	1	4267	1277	45	5		5	DCAF15	19	14071180	Silent	SNP	G	TCGA-76-6664-01A-11D-1845-08	4981669	14071180	45057803	49	20159											
XRN2	22803	broad.mit.edu	37	chr20	21367621	21367621	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctggtgggtatccacccagaCgagatgatcgtggagggaga	16	8	0	4			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr20:21367621C>A	uc002wsf.1	+	29	2859	c.2764C>A	c.(2764-2766)CGA>AGA	p.R922R	XRN2_uc002wsg.1_Silent_p.R846R|XRN2_uc010zsk.1_Silent_p.R868R|XRN2_uc002wsh.1_Silent_p.R60R	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	922					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						TCCACCCAGACGAGATGATCG	0.502													A	21367621	A	A	21367621	2	1	280	1	0	0	0	0	0	0	0	1	17457	528	19	5		5	XRN2	20	21367621	Silent	SNP	C	TCGA-76-6664-01A-11D-1845-08		21367621	41657899	50	20160											
MMP9	4318	broad.mit.edu	37	chr20	44639885	44639885	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accaccgacggtcgctccgaCggcttgccctggtgcagtac	12	16	0	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr20:44639885C>T	uc002xqz.2	+	5	772	c.753C>T	c.(751-753)GAC>GAT	p.D251D		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	251	Fibronectin type-II 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	GTCGCTCCGACGGCTTGCCCT	0.657													T	44639885	T	T	44639885	2	4	280	1	0	0	0	0	0	0	0	1	9669	535	19	1		1	MMP9	20	44639885	Silent	SNP	C	TCGA-76-6664-01A-11D-1845-08	23272264	44639885	18385635	51	20161											
ARFGEF2	10564	broad.mit.edu	37	chr20	47639713	47639713	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcagagcacatggttgccGcccaggtaagaacaggaggc	14	10	0	2			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr20:47639713G>A	uc002xtx.3	+	35	4902	c.4750G>A	c.(4750-4752)GCC>ACC	p.A1584T	ARFGEF2_uc010zyf.1_Missense_Mutation_p.A877T	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1584					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CATGGTTGCCGCCCAGGTAAG	0.413													A	47639713	A	A	47639713	3	1	280	1	0	0	0	0	1	0	0	0	853	1087	38	1	4888	1	ARFGEF2	20	47639713	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	2999828	47639713	15385807	52	20162											
HRH3	11255	broad.mit.edu	37	chr20	60791534	60791534	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	caccgccacccccgagggtcGcctccccggcctcagcgcct	10	23	1	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr20:60791534G>A	uc002ycf.2	-	3	1163	c.866C>T	c.(865-867)GCG>GTG	p.A289V	HRH3_uc002ycg.2_Intron|HRH3_uc002ych.2_Intron|HRH3_uc002yci.2_Missense_Mutation_p.A289V	NM_007232	NP_009163	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	289	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	CCCGAGGGTCGCCTCCCCGGC	0.736													A	60791534	A	A	60791534	3	1	280	1	0	0	0	0	1	0	0	0	7357	1087	38	1	475	1	HRH3	20	60791534	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	13151821	60791534	2233986	53	20163											
TMPRSS15	5651	broad.mit.edu	37	chr21	19642347	19642347	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ccctggcatacactccggggCgattaggcagggcacacttg	13	13	0	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr21:19642347C>T	uc002ykw.2	-	25	3030	c.2999G>A	c.(2998-3000)CGC>CAC	p.R1000H		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	1000	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CACTCCGGGGCGATTAGGCAG	0.448													T	19642347	T	T	19642347	3	4	280	1	0	0	0	0	1	0	0	0	16243	768	27	1	64	1	TMPRSS15	21	19642347	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08		19642347	28487548	54	20164											
AIFM3	150209	broad.mit.edu	37	chr22	21332217	21332217	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aggcgtgtttgcagctggcgAtgctgtcaccttcccccttg	12	13	1	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chr22:21332217A>T	uc002ztj.2	+	16	1618	c.1400A>T	c.(1399-1401)GAT>GTT	p.D467V	AIFM3_uc002ztk.2_Missense_Mutation_p.D467V|AIFM3_uc002ztl.2_Missense_Mutation_p.D473V|AIFM3_uc011ahx.1_Missense_Mutation_p.D455V|AIFM3_uc002ztm.1_Missense_Mutation_p.D279V|LZTR1_uc002ztn.2_5'Flank	NM_144704	NP_653305	Q96NN9	AIFM3_HUMAN	apoptosis-inducing factor,	467		FAD (Potential).			activation of caspase activity by cytochrome c|cell redox homeostasis|electron transport chain|induction of apoptosis|mitochondrial depolarization|transport	endoplasmic reticulum|mitochondrial inner membrane	2 iron, 2 sulfur cluster binding|caspase activator activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity|protein binding			ovary(2)|lung(2)	4	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GCAGCTGGCGATGCTGTCACC	0.582													T	21332217	T	T	21332217	3	4	280	1	0	0	0	0	1	0	0	0	428	333	12	5	1476	5	AIFM3	22	21332217	Missense_Mutation	SNP	A	TCGA-76-6664-01A-11D-1845-08		21332217	29972349	55	20165											
PNPLA4	8228	broad.mit.edu	37	chrX	7870101	7870101	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgcggggagatgtccagtcGtccactgaagggggagatgg	18	8	0	3			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chrX:7870101G>A	uc011mhq.1	-	6	721	c.559C>T	c.(559-561)CGA>TGA	p.R187*	PNPLA4_uc011mhr.1_Nonsense_Mutation_p.R187*|PNPLA4_uc011mhs.1_Nonsense_Mutation_p.R100*	NM_004650	NP_004641	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	187					lipid catabolic process		triglyceride lipase activity				0		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				ATGTCCAGTCGTCCACTGAAG	0.512													A	7870101	A	A	7870101	4	1	280	1	0	0	0	0	0	1	0	0	12167	1153	40	1	210	1	PNPLA4	23	7870101	Nonsense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08		7870101	147400459	56	20166											
SMS	6611	broad.mit.edu	37	chrX	21995314	21995314	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	aatataaaaattctacactcGaagcagtttggaaatattct	5	6	2	0			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chrX:21995314G>A	uc004dag.2	+	5	566	c.465G>A	c.(463-465)TCG>TCA	p.S155S	SMS_uc011mjq.1_Silent_p.S59S|SMS_uc004daf.1_Silent_p.S102S|SMS_uc010nfs.2_5'Flank|SMS_uc010nft.2_5'Flank	NM_004595	NP_004586	P52788	SPSY_HUMAN	spermine synthase	155					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			ovary(1)	1					Spermine(DB00127)	TTCTACACTCGAAGCAGTTTG	0.433													A	21995314	A	A	21995314	2	1	280	1	0	0	0	0	0	0	0	1	14813	1045	37	2		2	SMS	23	21995314	Silent	SNP	G	TCGA-76-6664-01A-11D-1845-08	14125213	21995314	133275246	57	20167											
MAOB	4129	broad.mit.edu	37	chrX	43628565	43628565	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	agaccctacctctcgggctgCtctctccccggcctctacag	8	19	3	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chrX:43628565C>G	uc004dfz.3	-	13	1512	c.1336G>C	c.(1336-1338)GCA>CCA	p.A446P	MAOB_uc011mkx.1_Missense_Mutation_p.S397T|MAOB_uc011mky.1_Missense_Mutation_p.A430P	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	446	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	TCTCGGGCTGCTCTCTCCCCG	0.572													G	43628565	G	G	43628565	3	3	280	1	0	0	0	0	1	0	0	0	9226	797	28	5	238	5	MAOB	23	43628565	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	21633251	43628565	111641995	58	20168											
CFP	5199	broad.mit.edu	37	chrX	47486225	47486225	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	tccgggtggcatcgccagcaCagaaggggcccccatgctgg	15	14	0	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chrX:47486225C>G	uc004dig.3	-	6	1013	c.887G>C	c.(886-888)TGT>TCT	p.C296S	CFP_uc004dih.2_Missense_Mutation_p.C296S|CFP_uc004dii.1_Missense_Mutation_p.C232S|CFP_uc010nhu.2_Missense_Mutation_p.C296S	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	296	TSP type-1 4.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3						ATCGCCAGCACAGAAGGGGCC	0.642													G	47486225	G	G	47486225	3	3	280	1	0	0	0	0	1	0	0	0	3293	478	17	5	538	5	CFP	23	47486225	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	3857660	47486225	107784335	59	20169											
DGAT2L6	347516	broad.mit.edu	37	chrX	69421881	69421881	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cactctcttcctcaagcagcGtaaaggttttgtgaagatgg	10	9	2	2			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chrX:69421881G>A	uc004dxx.1	+	5	711	c.614G>A	c.(613-615)CGT>CAT	p.R205H		NM_198512	NP_940914	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	205					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)	1						CTCAAGCAGCGTAAAGGTTTT	0.547													A	69421881	A	A	69421881	3	1	280	1	0	0	0	0	1	0	0	0	4459	1145	40	1	632	1	DGAT2L6	23	69421881	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	21935656	69421881	85848679	60	20170											
ATP7A	538	broad.mit.edu	37	chrX	77296145	77296145	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tgaagcctgaagcagaactgGctatccatattctgaaatct	8	9	2	4			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chrX:77296145G>T	uc004ecx.3	+	19	3875	c.3715G>T	c.(3715-3717)GCT>TCT	p.A1239S		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1239	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						AGCAGAACTGGCTATCCATAT	0.413													T	77296145	T	T	77296145	3	4	280	1	0	0	0	0	1	0	0	0	1190	1203	42	5	3785	5	ATP7A	23	77296145	Missense_Mutation	SNP	G	TCGA-76-6664-01A-11D-1845-08	7874264	77296145	77974415	61	20171											
TMSB15A	11013	broad.mit.edu	37	chrX	101770022	101770022	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	gggaagagtatttttttcttCagtattagttttcttcagtt	8	4	4	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chrX:101770022C>T	uc004eje.2	-	2	193	c.70G>A	c.(70-72)GAA>AAA	p.E24K		NM_021992	NP_068832	P0CG34	TB15A_HUMAN	thymosin-like 8	24					actin cytoskeleton organization|sequestering of actin monomers	cytoplasm|cytoskeleton	actin binding				0						TTTTTTTCTTCAGTATTAGTT	0.368													T	101770022	T	T	101770022	3	4	280	1	0	0	0	0	1	0	0	0	16252	835	29	3	75	3	TMSB15A	23	101770022	Missense_Mutation	SNP	C	TCGA-76-6664-01A-11D-1845-08	24473877	101770022	53500538	62	20172											
GPRASP2	114928	broad.mit.edu	37	chrX	101970131	101970131	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	taggtggcgctcgttctaaaActgatgccaaggcaatccct	10	11	1	1			TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chrX:101970131A>G	uc004ejk.2	+	4	1668	c.334A>G	c.(334-336)ACT>GCT	p.T112A	GPRASP2_uc004ejl.2_Missense_Mutation_p.T112A|GPRASP2_uc004ejm.2_Missense_Mutation_p.T112A|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	112						cytoplasm	protein binding			ovary(1)	1						TCGTTCTAAAACTGATGCCAA	0.572													G	101970131	G	G	101970131	3	3	280	1	0	0	0	0	1	0	0	0	6723	43	2	4	336	4	GPRASP2	23	101970131	Missense_Mutation	SNP	A	TCGA-76-6664-01A-11D-1845-08	200109	101970131	53300429	63	20173											
RAB9B	51209	broad.mit.edu	37	chrX	103080388	103080388	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgctcagggtccttcacatcCgcatagtaaataaattcttt	6	10	3	0	rs142893082	byFrequency	TCGA-76-6664-01A-11D-1845-08	TCGA-76-6664-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a8f17c6-060d-492e-8a39-53d9ac7035a4	43e20ea7-844f-4f2c-a1c2-a02e44e591d5	g.chrX:103080388C>T	uc004ell.1	-	3	612	c.327G>A	c.(325-327)GCG>GCA	p.A109A	RAB9B_uc004eli.1_Intron	NM_016370	NP_057454	Q9NP90	RAB9B_HUMAN	RAB9B, member RAS oncogene family	109					Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(3)	3						CCTTCACATCCGCATAGTAAA	0.488													T	103080388	T	T	103080388	2	4	280	1	0	0	0	0	0	0	0	1	12959	639	23	2		2	RAB9B	23	103080388	Silent	SNP	C	TCGA-76-6664-01A-11D-1845-08	1110257	103080388	52190172	64	20174											
HMGB4	127540	broad.mit.edu	37	chr1	34330273	34330273	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tcgaggaacttgaactctacCgtaaacaatgtaatgccagg	9	9	1	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr1:34330273C>T	uc001bxp.2	+	2	2224	c.481C>T	c.(481-483)CGT>TGT	p.R161C	CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxn.1_Intron|HMGB4_uc001bxq.2_Missense_Mutation_p.R87C	NM_145205	NP_660206	Q8WW32	HMGB4_HUMAN	HMG2 like isoform 1	161						nucleus	DNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TGAACTCTACCGTAAACAATG	0.478													T	34330273	T	T	34330273	3	4	281	1	0	0	0	0	1	0	0	0	7228	652	23	2	483	2	HMGB4	1	34330273	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08		34330273	214920348	1	20175											
STK40	83931	broad.mit.edu	37	chr1	36820904	36820904	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgatgacgtagtgctgcaggTtgatgaggtcagcggtctta	15	6	2	4			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr1:36820904T>C	uc001cak.1	-	6	880	c.473A>G	c.(472-474)AAC>AGC	p.N158S	STK40_uc001cal.1_Missense_Mutation_p.N163S|STK40_uc001cam.1_Missense_Mutation_p.N158S|STK40_uc009vva.1_Missense_Mutation_p.N158S|STK40_uc001can.1_Missense_Mutation_p.N158S	NM_032017	NP_114406	Q8N2I9	STK40_HUMAN	serine/threonine kinase 40	158	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)				GTGCTGCAGGTTGATGAGGTC	0.562													C	36820904	C	C	36820904	3	2	281	1	0	0	0	0	1	0	0	0	15306	1725	60	4	862	4	STK40	1	36820904	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08	2490631	36820904	212429717	2	20176											
CTPS	1503	broad.mit.edu	37	chr1	41461704	41461705	+	Frame_Shift_Ins	INS	-	A	A													cctattgagaggcagccaagINSaaaaatgctgatgaaatgga							TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr1:41461704_41461705insA	uc001cgk.3	+	8	1344_1345	c.836_837insA	c.(835-837)AGAfs	p.R279fs	CTPS_uc010ojo.1_Frame_Shift_Ins_p.R48fs|CTPS_uc010ojp.1_Frame_Shift_Ins_p.R286fs|CTPS_uc001cgl.3_Frame_Shift_Ins_p.R279fs|CTPS_uc010ojq.1_Frame_Shift_Ins_p.R123fs|CTPS_uc009vwe.2_5'UTR	NM_001905	NP_001896	P17812	PYRG1_HUMAN	CTP synthase	279					CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)			L-Glutamine(DB00130)	AGGCAGCCAAGAAAAATGCTGA	0.475													A	41461705	A	A	41461704	7	5	281	1	0	1	1	0	0	0	0	0	4022	942	33	0	862	0	CTPS	1	41461704	Frame_Shift_Ins	INS	-	TCGA-81-5910-01A-11D-1696-08	4640800	41461704	207788917	3	20177											
IFI44L	10964	broad.mit.edu	37	chr1	79094655	79094655	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ggaattaaggataacctagaCgacataaagaggataattaa	9	4	0	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr1:79094655C>T	uc010oro.1	+	3	677	c.498C>T	c.(496-498)GAC>GAT	p.D166D	IFI44L_uc010orp.1_Translation_Start_Site|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	166						cytoplasm					0						ATAACCTAGACGACATAAAGA	0.294													T	79094655	T	T	79094655	2	4	281	1	0	0	0	0	0	0	0	1	7518	535	19	1		1	IFI44L	1	79094655	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08	37632951	79094655	170155966	4	20178											
OR6N1	128372	broad.mit.edu	37	chr1	158735944	158735944	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aggagggaagtcacaaaagaCgtgctgaatgcgattggggc	16	6	1	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr1:158735944C>T	uc010piq.1	-	1	529	c.529G>A	c.(529-531)GTC>ATC	p.V177I		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCACAAAAGACGTGCTGAATG	0.473													T	158735944	T	T	158735944	3	4	281	1	0	0	0	0	1	0	0	0	11206	536	19	1	412	1	OR6N1	1	158735944	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08	79641289	158735944	90514677	5	20179											
USH2A	7399	broad.mit.edu	37	chr1	216419959	216419959	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gattacaccttcttccttgaCgattaggcacacacaggcac	7	13	1	1	rs146916397	byFrequency	TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr1:216419959C>T	uc001hku.1	-	13	3164	c.2777G>A	c.(2776-2778)CGT>CAT	p.R926H	USH2A_uc001hkv.2_Missense_Mutation_p.R926H	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	926	Laminin EGF-like 8.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCTTCCTTGACGATTAGGCAC	0.423										HNSCC(13;0.011)			T	216419959	T	T	216419959	3	4	281	1	0	0	0	0	1	0	0	0	17033	536	19	1	13085	1	USH2A	1	216419959	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08	57684015	216419959	32830662	6	20180											
OR2L2	26246	broad.mit.edu	37	chr1	248202093	248202094	+	Frame_Shift_Ins	INS	-	T	T													aagtccagagccatcaatcaINSttttttctgtgatgttccag							TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr1:248202093_248202094insT	uc001idw.2	+	1	620_621	c.524_525insT	c.(523-525)CATfs	p.H175fs	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GCCATCAATCATTTTTTCTGTG	0.431													T	248202094	T	T	248202093	7	5	281	1	0	1	1	0	0	0	0	0	11007	217	8	0	526	0	OR2L2	1	248202093	Frame_Shift_Ins	INS	-	TCGA-81-5910-01A-11D-1696-08	31782134	248202093	1048528	7	20181											
AFF3	3899	broad.mit.edu	37	chr2	100209854	100209854	+	Missense_Mutation	SNP	G	C	C	1	0	0	1	0	1	1	1	0	1	1	0	gatctcatcactgtcctttaGaggggagagaagttcgttcc	11	9	2	2	rs56151323		TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr2:100209854G>C	uc002tag.2	-	14	2505	c.2269C>G	c.(2269-2271)CTA>GTA	p.L757V	AFF3_uc002taf.2_Missense_Mutation_p.L782V|AFF3_uc010fiq.1_Missense_Mutation_p.L757V|AFF3_uc010yvr.1_Missense_Mutation_p.L910V|AFF3_uc002tah.1_Missense_Mutation_p.L782V	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	757					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CTGTCCTTTAGAGGGGAGAGA	0.572													C	100209854	C	C	100209854	3	2	281	1	0	0	0	0	1	0	0	0	358	933	33	5	1455	5	AFF3	2	100209854	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08		100209854	142989519	8	20182											
SCN9A	6335	broad.mit.edu	37	chr2	167162345	167162345	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagccagttccacgggtcacGaagaaaagtgaattctccta	9	11	2	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr2:167162345G>A	uc010fpl.2	-	5	894	c.553C>T	c.(553-555)CGT>TGT	p.R185C	SCN9A_uc002udr.1_Missense_Mutation_p.R56C|SCN9A_uc002uds.1_Missense_Mutation_p.R56C|SCN9A_uc002udt.1_Missense_Mutation_p.R56C	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	185	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CACGGGTCACGAAGAAAAGTG	0.378													A	167162345	A	A	167162345	3	1	281	1	0	0	0	0	1	0	0	0	13925	1058	37	2	5472	2	SCN9A	2	167162345	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08	66952491	167162345	76037028	9	20183											
XIRP2	129446	broad.mit.edu	37	chr2	168100110	168100110	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	aaaagaagtataaaatgtttCgaaactcaaccattatatgt	5	5	1	1	rs76149079	byFrequency	TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr2:168100110C>T	uc002udx.2	+	8	2226	c.2208C>T	c.(2206-2208)TTC>TTT	p.F736F	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.F561F|XIRP2_uc010fpq.2_Silent_p.F514F|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	561	Xin 6.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TAAAATGTTTCGAAACTCAAC	0.368													T	168100110	T	T	168100110	2	4	281	1	0	0	0	0	0	0	0	1	17427	883	31	2		2	XIRP2	2	168100110	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08	937765	168100110	75099263	10	20184											
LRP2	4036	broad.mit.edu	37	chr2	170145548	170145548	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcacttaccaacacaggtacGgctgtcattgtggttgatga	10	9	2	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr2:170145548G>A	uc002ues.2	-	9	1243	c.1030C>T	c.(1030-1032)CGT>TGT	p.R344C	LRP2_uc010zdf.1_Missense_Mutation_p.R344C	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	344	EGF-like 1.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACACAGGTACGGCTGTCATTG	0.522													A	170145548	A	A	170145548	3	1	281	1	0	0	0	0	1	0	0	0	8956	1116	39	2	13221	2	LRP2	2	170145548	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08	2045438	170145548	73053825	11	20185											
TTN	7273	broad.mit.edu	37	chr2	179498195	179498195	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccacagtcacacacatattcGcctttatctttaaggtccgc	5	14	2	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr2:179498195G>A	uc010zfg.1	-	181	35411	c.35187C>T	c.(35185-35187)GGC>GGT	p.G11729G	TTN_uc010zfh.1_Silent_p.G5424G|TTN_uc010zfi.1_Silent_p.G5357G|TTN_uc010zfj.1_Silent_p.G5232G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12656							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACATATTCGCCTTTATCTT	0.428													A	179498195	A	A	179498195	2	1	281	1	0	0	0	0	0	0	0	1	16732	1074	38	1		1	TTN	2	179498195	Silent	SNP	G	TCGA-81-5910-01A-11D-1696-08	9352647	179498195	63701178	12	20186											
MPP4	58538	broad.mit.edu	37	chr2	202545627	202545627	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggtctgagatttttcgggccTgccaccagagggcatcattc	12	11	2	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr2:202545627T>G	uc002uyk.3	-	10	1071	c.863A>C	c.(862-864)CAG>CCG	p.Q288P	MPP4_uc010ftj.2_Missense_Mutation_p.Q288P|MPP4_uc010zhq.1_Missense_Mutation_p.Q288P|MPP4_uc010zhr.1_Missense_Mutation_p.Q288P|MPP4_uc010zhs.1_Missense_Mutation_p.Q244P|MPP4_uc002uyj.3_Missense_Mutation_p.Q244P|MPP4_uc010zht.1_Missense_Mutation_p.Q261P|MPP4_uc002uyl.3_RNA|MPP4_uc010ftk.2_Missense_Mutation_p.Q275P|MPP4_uc002uym.1_Missense_Mutation_p.Q257P|MPP4_uc002uyn.2_Missense_Mutation_p.Q244P	NM_033066	NP_149055	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4	288	SH3.					cytoplasm	protein binding				0						TTTTCGGGCCTGCCACCAGAG	0.582											OREG0015145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	G	202545627	G	G	202545627	3	3	281	1	0	0	0	0	1	0	0	0	9736	1580	55	5	1102	5	MPP4	2	202545627	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08	23047432	202545627	40653746	13	20187											
PAX3	5077	broad.mit.edu	37	chr2	223066892	223066892	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgaggtaccccaccgtggttGgtcaggagtcccattaccta	11	12	1	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr2:223066892G>A	uc010fwo.2	-	8	1557	c.1191C>T	c.(1189-1191)ACC>ACT	p.T397T	PAX3_uc002vmt.1_Silent_p.T397T|PAX3_uc002vmy.1_Silent_p.T396T|PAX3_uc002vmv.1_Silent_p.T397T|PAX3_uc002vmw.1_Intron|PAX3_uc002vmx.1_Intron	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	397					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACCGTGGTTGGTCAGGAGTC	0.537			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						A	223066892	A	A	223066892	2	1	281	1	0	0	0	0	0	0	0	1	11480	1335	47	3		3	PAX3	2	223066892	Silent	SNP	G	TCGA-81-5910-01A-11D-1696-08	20521265	223066892	20132481	14	20188											
CRELD1	78987	broad.mit.edu	37	chr3	9976243	9976243	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	ctccccagtcttctcccccgCctcagccccatccgtgtcat	5	22	4	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr3:9976243C>A	uc003bug.2	+	2	239	c.121C>A	c.(121-123)CCT>ACT	p.P41T	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Missense_Mutation_p.P41T|CRELD1_uc003buh.2_Missense_Mutation_p.P41T|CRELD1_uc003bui.2_Missense_Mutation_p.P41T|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	41	Pro-rich.|Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						TTCTCCCCCGCCTCAGCCCCA	0.582													A	9976243	A	A	9976243	3	1	281	1	0	0	0	0	1	0	0	0	3866	739	26	5	123	5	CRELD1	3	9976243	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08		9976243	188046187	15	20189											
STXBP5L	9515	broad.mit.edu	37	chr3	120976169	120976169	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggagtaacaaaggacagtatTccatgcctcaagtaagagtt	10	7	1	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr3:120976169T>G	uc003eec.3	+	17	1961	c.1821T>G	c.(1819-1821)ATT>ATG	p.I607M	STXBP5L_uc011bji.1_Missense_Mutation_p.I607M	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	607	WD 9.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AGGACAGTATTCCATGCCTCA	0.368													G	120976169	G	G	120976169	3	3	281	1	0	0	0	0	1	0	0	0	15356	1771	62	5	1883	5	STXBP5L	3	120976169	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08	110999926	120976169	77046261	16	20190											
TP63	8626	broad.mit.edu	37	chr3	189456442	189456442	+	Missense_Mutation	SNP	C	T	T	0	1	1	0	1	0	1	0	1	1	0	1	atgtgttaggcctatatgttCagttcagcccattgacttga	9	8	2	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr3:189456442C>T	uc003fry.2	+	3	292	c.203C>T	c.(202-204)TCA>TTA	p.S68L	TP63_uc003frx.2_Missense_Mutation_p.S68L|TP63_uc003frz.2_Missense_Mutation_p.S68L|TP63_uc010hzc.1_Missense_Mutation_p.S68L	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	68	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CCTATATGTTCAGTTCAGCCC	0.408									Hay-Wells_syndrome	HNSCC(45;0.13)			T	189456442	T	T	189456442	3	4	281	1	0	0	0	0	1	0	0	0	16389	838	29	3	213	3	TP63	3	189456442	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08	68480273	189456442	8565988	17	20191											
ANAPC4	29945	broad.mit.edu	37	chr4	25416009	25416009	+	Splice_Site	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgtatagagataccagaaggTaattctgtttacctattgga	9	5	1	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr4:25416009T>C	uc003gro.2	+	23	1814	c.1685_splice	c.e23+2	p.S562_splice	ANAPC4_uc003grp.2_Splice_Site_p.S448_splice|ANAPC4_uc003grq.2_Splice_Site_p.S15_splice	NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	anaphase-promoting complex subunit 4						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)				TACCAGAAGGTAATTCTGTTT	0.294													C	25416009	C	C	25416009	5	2	281	1	0	0	0	0	0	0	1	0	604	1652	57	4	1773	4	ANAPC4	4	25416009	Splice_Site	SNP	T	TCGA-81-5910-01A-11D-1696-08		25416009	165738267	18	20192											
NIPAL1	152519	broad.mit.edu	37	chr4	48027184	48027184	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcctgtgctctacacggaccTgaattacagcataaacaact	6	12	1	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr4:48027184T>C	uc003gxw.2	+	2	212	c.146T>C	c.(145-147)CTG>CCG	p.L49P		NM_207330	NP_997213	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	49	Extracellular (Potential).					integral to membrane					0						TACACGGACCTGAATTACAGC	0.438													C	48027184	C	C	48027184	3	2	281	1	0	0	0	0	1	0	0	0	10424	1580	55	4	152	4	NIPAL1	4	48027184	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08	22611175	48027184	143127092	19	20193											
KDR	3791	broad.mit.edu	37	chr4	55946311	55946311	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agatgccacagactccctgcTtttgctgggcaccattccac	8	15	0	2	rs66480054		TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr4:55946311T>G	uc003has.2	-	30	4170	c.3868A>C	c.(3868-3870)AGC>CGC	p.S1290R	KDR_uc003hat.1_Missense_Mutation_p.S1290R	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1290	Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GACTCCCTGCTTTTGCTGGGC	0.507			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			G	55946311	G	G	55946311	3	3	281	1	0	0	0	0	1	0	0	0	8139	1609	56	5	206	5	KDR	4	55946311	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08	7919127	55946311	135207965	20	20194											
CARD6	84674	broad.mit.edu	37	chr5	40853460	40853460	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tttcctctggagaaaacatgGctgggacagctgaaggtgag	14	7	1	3			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr5:40853460G>A	uc003jmg.2	+	3	2101	c.2026G>A	c.(2026-2028)GCT>ACT	p.A676T		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	676					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						AGAAAACATGGCTGGGACAGC	0.493													A	40853460	A	A	40853460	3	1	281	1	0	0	0	0	1	0	0	0	2650	1203	42	3	2036	3	CARD6	5	40853460	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08		40853460	140061800	21	20195											
TREM1	54210	broad.mit.edu	37	chr6	41254356	41254356	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ttgtcttacctgagacaaagAgcatccacagcagcccccag	8	14	1	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr6:41254356A>G	uc003oqf.1	-	1	102	c.38T>C	c.(37-39)CTC>CCC	p.L13P	TREM1_uc003oqg.1_Missense_Mutation_p.L13P	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	13					blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	TGAGACAAAGAGCATCCACAG	0.587													G	41254356	G	G	41254356	3	3	281	1	0	0	0	0	1	0	0	0	16467	304	11	4	682	4	TREM1	6	41254356	Missense_Mutation	SNP	A	TCGA-81-5910-01A-11D-1696-08		41254356	129860711	22	20196											
BVES	11149	broad.mit.edu	37	chr6	105577294	105577294	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatacgacagatgcaaaatgTtgacacccaagaacacagag	9	9	0	4			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr6:105577294T>C	uc003pqw.2	-	3	468	c.311A>G	c.(310-312)AAC>AGC	p.N104S	BVES_uc003pqx.2_Missense_Mutation_p.N104S|BVES_uc003pqy.2_Missense_Mutation_p.N104S	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	104	Helical; (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				ATGCAAAATGTTGACACCCAA	0.363													C	105577294	C	C	105577294	3	2	281	1	0	0	0	0	1	0	0	0	1575	1725	60	4	795	4	BVES	6	105577294	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08	64322938	105577294	65537773	23	20197											
EGFR	1956	broad.mit.edu	37	chr7	55221710	55221710	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tctctcctccataggtctgcCgcaaattccgagacgaagcc	8	15	2	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr7:55221710C>T	uc003tqk.2	+	7	1000	c.754C>T	c.(754-756)CGC>TGC	p.R252C	EGFR_uc003tqh.2_Missense_Mutation_p.R252C|EGFR_uc003tqi.2_Missense_Mutation_p.R252C|EGFR_uc003tqj.2_Missense_Mutation_p.R252C|EGFR_uc010kzg.1_Missense_Mutation_p.R207C|EGFR_uc011kco.1_Missense_Mutation_p.R199C|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	252	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.R252C(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATAGGTCTGCCGCAAATTCCG	0.582		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221710	T	T	55221710	3	4	281	1	0	0	0	0	1	0	0	0	4967	652	23	2	780	2	EGFR	7	55221710	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08		55221710	103916953	24	20198											
MCM7	4176	broad.mit.edu	37	chr7	99691889	99691889	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctctcgcctcatctccacGtatgctgctgtgatgtagtc	9	14	3	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr7:99691889G>A	uc003usw.1	-	13	2265	c.1755C>T	c.(1753-1755)TAC>TAT	p.Y585Y	MCM7_uc003usv.1_Silent_p.Y409Y|MCM7_uc003usx.1_Silent_p.Y409Y|uc003usy.1_5'Flank|MIR25_hsa-mir-25|MI0000082_5'Flank|uc003usz.1_5'Flank|MIR93_hsa-mir-93|MI0000095_5'Flank|uc003uta.1_5'Flank|MIR106B_hsa-mir-106b|MI0000734_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	585	Interaction with ATRIP.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	TCATCTCCACGTATGCTGCTG	0.577													A	99691889	A	A	99691889	2	1	281	1	0	0	0	0	0	0	0	1	9392	1140	40	1		1	MCM7	7	99691889	Silent	SNP	G	TCGA-81-5910-01A-11D-1696-08	44470179	99691889	59446774	25	20199											
FBXL13	222235	broad.mit.edu	37	chr7	102669857	102669857	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	caggcttttatcatcaattcCggagtcatctaaagtaaata	6	8	4	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr7:102669857C>T	uc003vaq.2	-	3	436	c.9G>A	c.(7-9)CCG>CCA	p.P3P	FBXL13_uc010lir.1_Silent_p.P3P|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Silent_p.P3P|FBXL13_uc003vav.2_RNA	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	3											0						TCATCAATTCCGGAGTCATCT	0.294													T	102669857	T	T	102669857	2	4	281	1	0	0	0	0	0	0	0	1	5709	639	23	2		2	FBXL13	7	102669857	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08	2977968	102669857	56468806	26	20200											
RELN	5649	broad.mit.edu	37	chr7	103234169	103234169	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	caggtttcagggtcaaatctCgagttactgcaaatcgatct	9	9	4	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr7:103234169C>T	uc003vca.2	-	27	4032	c.3872G>A	c.(3871-3873)CGA>CAA	p.R1291Q	RELN_uc010liz.2_Missense_Mutation_p.R1291Q	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1291					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGTCAAATCTCGAGTTACTGC	0.393													T	103234169	T	T	103234169	3	4	281	1	0	0	0	0	1	0	0	0	13220	884	31	2	6666	2	RELN	7	103234169	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08	564312	103234169	55904494	27	20201											
NOBOX	135935	broad.mit.edu	37	chr7	144098554	144098554	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcttctccagagactgctggCggcttcttctctcctgagat	10	13	3	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr7:144098554C>T	uc011kue.1	-	4	429	c.429G>A	c.(427-429)CCG>CCA	p.P143P		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	143					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					AGACTGCTGGCGGCTTCTTCT	0.652													T	144098554	T	T	144098554	2	4	281	1	0	0	0	0	0	0	0	1	10512	755	27	1		1	NOBOX	7	144098554	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08	40864385	144098554	15040109	28	20202											
C9orf66	157983	broad.mit.edu	37	chr9	215042	215042	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	atcaacaggtaagacgccccCcgcggcgcgcaggttgcggc	14	15	1	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr9:215042C>A	uc003zge.3	-	1	852	c.355G>T	c.(355-357)GGG>TGG	p.G119W	DOCK8_uc011lls.1_Intron|DOCK8_uc003zgf.2_Intron	NM_152569	NP_689782	Q5T8R8	CI066_HUMAN	hypothetical protein LOC157983	119										central_nervous_system(1)	1	all_lung(41;0.218)	all_cancers(5;2.09e-12)|all_epithelial(5;6.16e-09)|all_lung(10;1.15e-08)|Lung NSC(10;1.91e-08)|Acute lymphoblastic leukemia(5;0.00457)|all_hematologic(5;0.0332)|Breast(48;0.0646)|Prostate(43;0.137)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		AAGACGCCCCCCGCGGCGCGC	0.731													A	215042	A	A	215042	3	1	281	1	0	0	0	0	1	0	0	0	2490	623	22	5	536	5	C9orf66	9	215042	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08		215042	140998389	29	20203											
FREM1	158326	broad.mit.edu	37	chr9	14848723	14848723	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tctgatggagatgtggactgTcataggtgcactcctttcaa	11	8	3	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr9:14848723T>A	uc003zlm.2	-	7	1791	c.1201A>T	c.(1201-1203)ACA>TCA	p.T401S	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	401	CSPG 2.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		ATGTGGACTGTCATAGGTGCA	0.448													A	14848723	A	A	14848723	3	1	281	1	0	0	0	0	1	0	0	0	6044	1667	58	5	5512	5	FREM1	9	14848723	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08	14633681	14848723	126364708	30	20204											
OR13F1	138805	broad.mit.edu	37	chr9	107267210	107267210	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tctcttatgcatttatcctcGccagtatcctgagaatcagc	6	12	2	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr9:107267210G>A	uc011lvm.1	+	1	667	c.667G>A	c.(667-669)GCC>ACC	p.A223T		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						ATTTATCCTCGCCAGTATCCT	0.478													A	107267210	A	A	107267210	3	1	281	1	0	0	0	0	1	0	0	0	10941	1087	38	1	669	1	OR13F1	9	107267210	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08	92418487	107267210	33946221	31	20205											
ANGPTL2	23452	broad.mit.edu	37	chr9	129854001	129854001	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgaactgcttgccgttgtgCcatgtaaaggagtcacccgc	12	11	1	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr9:129854001C>T	uc004bqr.1	-	4	1730	c.1230G>A	c.(1228-1230)TGG>TGA	p.W410*	RALGPS1_uc004bqo.1_Intron|RALGPS1_uc011mab.1_Intron|RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron|ANGPTL2_uc010mxg.1_Nonsense_Mutation_p.W108*	NM_012098	NP_036230	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2 precursor	410	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding				0						TGCCGTTGTGCCATGTAAAGG	0.532													T	129854001	T	T	129854001	4	4	281	1	0	0	0	0	0	1	0	0	614	740	26	3	259	3	ANGPTL2	9	129854001	Nonsense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08	22586791	129854001	11359430	32	20206											
SETX	23064	broad.mit.edu	37	chr9	135202099	135202099	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tcaaaatcgactgtatccccTttgacttattttttagagac	5	9	1	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr9:135202099T>C	uc004cbk.2	-	10	5069	c.4886A>G	c.(4885-4887)AAG>AGG	p.K1629R	SETX_uc004cbj.2_Missense_Mutation_p.K1248R|SETX_uc010mzt.2_Missense_Mutation_p.K1248R	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1629					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CTGTATCCCCTTTGACTTATT	0.398													C	135202099	C	C	135202099	3	2	281	1	0	0	0	0	1	0	0	0	14141	1609	56	4	3215	4	SETX	9	135202099	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08	5348098	135202099	6011332	33	20207											
RALGDS	5900	broad.mit.edu	37	chr9	135975714	135975714	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ccggctcctcctcctccaggTtgtgtttgtccatggccttg	10	15	0	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr9:135975714T>C	uc004cco.2	-	17	2530	c.2510A>G	c.(2509-2511)AAC>AGC	p.N837S	RALGDS_uc004cct.1_5'Flank|RALGDS_uc004ccn.2_Missense_Mutation_p.N25S|RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.N825S|RALGDS_uc004ccr.2_Missense_Mutation_p.N836S|RALGDS_uc011mcv.1_Missense_Mutation_p.N808S|RALGDS_uc004ccs.2_Missense_Mutation_p.N782S|RALGDS_uc011mcw.1_Missense_Mutation_p.N908S|RALGDS_uc004ccv.1_3'UTR|RALGDS_uc004ccu.1_3'UTR	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	837	Ras-associating.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CTCCTCCAGGTTGTGTTTGTC	0.592			T	CIITA	PMBL|Hodgkin Lymphona|								C	135975714	C	C	135975714	3	2	281	1	0	0	0	0	1	0	0	0	13016	1725	60	4	242	4	RALGDS	9	135975714	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08	773615	135975714	5237717	34	20208											
PTEN	5728	broad.mit.edu	37	chr10	89711891	89711891	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ccagggagtaactattcccaGtcagaggcgctatgtgtatt	11	9	1	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr10:89711891G>A	uc001kfb.2	+	7	1540	c.509G>A	c.(508-510)AGT>AAT	p.S170N		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	170	Phosphatase tensin-type.		S -> N (loss of phosphatase activity towards Ins(1,3,4,5)P4; retains ability to bind phospholipid membranes).|S -> R (in BZS; severely reduced protein phosphatase activity; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.V166fs*17(3)|p.?(3)|p.G165fs*9(3)|p.S170N(3)|p.S170I(3)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.V166fs*10(1)|p.G165_K342del(1)|p.G165_*404del(1)|p.S170fs*13(1)|p.S170G(1)|p.S170fs*8(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ACTATTCCCAGTCAGAGGCGC	0.353		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89711891	A	A	89711891	3	1	281	1	0	0	0	0	1	0	0	0	12738	1029	36	3	531	3	PTEN	10	89711891	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08		89711891	45822856	35	20209											
CELF1	10658	broad.mit.edu	37	chr11	47496959	47496959	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggttgtacagagtggggagcGcagcagcagcatattgctgg	17	7	0	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr11:47496959G>A	uc001nfl.2	-	10	1128	c.1118C>T	c.(1117-1119)GCG>GTG	p.A373V	CELF1_uc001nfm.2_Missense_Mutation_p.A370V|CELF1_uc001nfn.2_Missense_Mutation_p.A369V|CELF1_uc001nfo.1_Missense_Mutation_p.A399V|CELF1_uc010rhm.1_Missense_Mutation_p.A372V|CELF1_uc001nfp.2_Missense_Mutation_p.A401V|CELF1_uc001nfq.1_Missense_Mutation_p.A373V|CELF1_uc001nfr.1_Missense_Mutation_p.A373V	NM_001025596	NP_001020767	Q92879	CELF1_HUMAN	CUG triplet repeat, RNA-binding protein 1	373					embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|ovary(1)	3						AGTGGGGAGCGCAGCAGCAGC	0.577													A	47496959	A	A	47496959	3	1	281	1	0	0	0	0	1	0	0	0	3215	1087	38	1	354	1	CELF1	11	47496959	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08		47496959	87509557	36	20210											
ANO1	55107	broad.mit.edu	37	chr11	70009414	70009414	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttggacgcccgggcgactacGtgtacattttccgttccttc	10	13	0	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr11:70009414G>A	uc001opj.2	+	19	2223	c.1918G>A	c.(1918-1920)GTG>ATG	p.V640M	ANO1_uc001opk.1_Missense_Mutation_p.V582M|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.V349M	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	640	Extracellular (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						GGGCGACTACGTGTACATTTT	0.527													A	70009414	A	A	70009414	3	1	281	1	0	0	0	0	1	0	0	0	695	1145	40	1	1992	1	ANO1	11	70009414	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08	22512455	70009414	64997102	37	20211											
NFRKB	4798	broad.mit.edu	37	chr11	129762715	129762715	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cacggaccaagttccagaggAtctgtcagcatatggtctaa	10	10	3	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr11:129762715A>C	uc001qfi.2	-	3	231	c.30T>G	c.(28-30)GAT>GAG	p.D10E	NFRKB_uc001qfg.2_Missense_Mutation_p.D23E|NFRKB_uc001qfh.2_Missense_Mutation_p.D33E|NFRKB_uc010sbw.1_Missense_Mutation_p.D10E	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	10					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GTTCCAGAGGATCTGTCAGCA	0.522													C	129762715	C	C	129762715	3	2	281	1	0	0	0	0	1	0	0	0	10384	330	12	5	4005	5	NFRKB	11	129762715	Missense_Mutation	SNP	A	TCGA-81-5910-01A-11D-1696-08	59753301	129762715	5243801	38	20212											
CACNA1C	775	broad.mit.edu	37	chr12	2602399	2602399	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tccccttgtgcgctggaaacGggccacgggcggcagtgcca	15	14	0	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr12:2602399G>A	uc009zdu.1	+	7	1273	c.960G>A	c.(958-960)ACG>ACA	p.T320T	CACNA1C_uc009zdv.1_Silent_p.T317T|CACNA1C_uc001qkb.2_Silent_p.T320T|CACNA1C_uc001qkc.2_Silent_p.T320T|CACNA1C_uc001qke.2_Silent_p.T320T|CACNA1C_uc001qkf.2_Silent_p.T320T|CACNA1C_uc001qjz.2_Silent_p.T320T|CACNA1C_uc001qkd.2_Silent_p.T320T|CACNA1C_uc001qkg.2_Silent_p.T320T|CACNA1C_uc009zdw.1_Silent_p.T320T|CACNA1C_uc001qkh.2_Silent_p.T320T|CACNA1C_uc001qkl.2_Silent_p.T320T|CACNA1C_uc001qkn.2_Silent_p.T320T|CACNA1C_uc001qko.2_Silent_p.T320T|CACNA1C_uc001qkp.2_Silent_p.T320T|CACNA1C_uc001qkr.2_Silent_p.T320T|CACNA1C_uc001qku.2_Silent_p.T320T|CACNA1C_uc001qkq.2_Silent_p.T320T|CACNA1C_uc001qks.2_Silent_p.T320T|CACNA1C_uc001qkt.2_Silent_p.T320T|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_Silent_p.T56T|CACNA1C_uc001qkj.1_Silent_p.T56T|CACNA1C_uc001qkk.1_Silent_p.T56T|CACNA1C_uc001qkm.1_Silent_p.T56T	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	320	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CGCTGGAAACGGGCCACGGGC	0.607													A	2602399	A	A	2602399	2	1	281	1	0	0	0	0	0	0	0	1	2540	1103	39	2		2	CACNA1C	12	2602399	Silent	SNP	G	TCGA-81-5910-01A-11D-1696-08		2602399	131249496	39	20213											
CCDC41	51134	broad.mit.edu	37	chr12	94761893	94761893	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctttggcagcttgtactttaCgtattaattcacgatccttt	6	9	1	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr12:94761893C>T	uc001tdd.2	-	10	1719	c.1133G>A	c.(1132-1134)CGT>CAT	p.R378H	CCDC41_uc001tde.2_Missense_Mutation_p.R378H|CCDC41_uc009zsw.1_RNA	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	370	Potential.										0						TTGTACTTTACGTATTAATTC	0.333													T	94761893	T	T	94761893	3	4	281	1	0	0	0	0	1	0	0	0	2813	536	19	1	1004	1	CCDC41	12	94761893	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08	92159494	94761893	39090002	40	20214											
STAB2	55576	broad.mit.edu	37	chr12	104102273	104102273	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	acccttgggagatggctcctGtgactgtgatgttggctggc	15	9	0	3			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr12:104102273G>T	uc001tjw.2	+	39	4433	c.4247G>T	c.(4246-4248)TGT>TTT	p.C1416F		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1416	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GATGGCTCCTGTGACTGTGAT	0.478													T	104102273	T	T	104102273	3	4	281	1	0	0	0	0	1	0	0	0	15237	1377	48	5	4401	5	STAB2	12	104102273	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08	9340380	104102273	29749622	41	20215											
PCID2	55795	broad.mit.edu	37	chr13	113852564	113852564	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	aagacttgttgacacttctcCtctggagaggccatctgatt	9	10	3	4			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr13:113852564C>T	uc010tju.1	-	3	222	c.141G>A	c.(139-141)GAG>GAA	p.E47E	PCID2_uc010tjv.1_Silent_p.E47E|PCID2_uc010tjw.1_Silent_p.E47E|PCID2_uc001vte.2_5'UTR|PCID2_uc001vtd.2_5'UTR|PCID2_uc001vtf.2_5'UTR|PCID2_uc001vtg.1_RNA	NM_001127203	NP_001120675	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	47					negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			GACACTTCTCCTCTGGAGAGG	0.358													T	113852564	T	T	113852564	2	4	281	1	0	0	0	0	0	0	0	1	11579	680	24	3		3	PCID2	13	113852564	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08		113852564	1317314	42	20216											
LRFN5	145581	broad.mit.edu	37	chr14	42356780	42356780	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	ggggagaccctgagcctgcaAttcactggatttctcctgaa	11	11	2	3			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr14:42356780A>G	uc001wvm.2	+	3	2150	c.952A>G	c.(952-954)ATT>GTT	p.I318V	LRFN5_uc010ana.2_Missense_Mutation_p.I318V	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	318	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGAGCCTGCAATTCACTGGAT	0.463										HNSCC(30;0.082)			G	42356780	G	G	42356780	3	3	281	1	0	0	0	0	1	0	0	0	8941	101	4	4	954	4	LRFN5	14	42356780	Missense_Mutation	SNP	A	TCGA-81-5910-01A-11D-1696-08		42356780	64992760	43	20217											
NDN	4692	broad.mit.edu	37	chr15	23931738	23931738	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atgcgcagcacgttccagacGgcgctctctctggcgccgcg	13	16	2	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr15:23931738G>A	uc001ywk.2	-	1	713	c.627C>T	c.(625-627)GCC>GCT	p.A209A		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	209	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CGTTCCAGACGGCGCTCTCTC	0.632									Prader-Willi_syndrome				A	23931738	A	A	23931738	2	1	281	1	0	0	0	0	0	0	0	1	10247	1103	39	2		2	NDN	15	23931738	Silent	SNP	G	TCGA-81-5910-01A-11D-1696-08		23931738	78599654	44	20218											
ACSM1	116285	broad.mit.edu	37	chr16	20651783	20651783	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctggtttgcaccacctacCgtttccgactgcccatagtt	7	14	1	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr16:20651783C>T	uc002dhm.1	-	7	1184	c.1116G>A	c.(1114-1116)ACG>ACA	p.T372T	ACSM1_uc002dhn.1_Intron|ACSM1_uc010bwg.1_Silent_p.T372T	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	372					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						caCCACCTACCGTTTCCGACT	0.313													T	20651783	T	T	20651783	2	4	281	1	0	0	0	0	0	0	0	1	182	666	23	2		2	ACSM1	16	20651783	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08		20651783	69702970	45	20219											
SCNN1B	6338	broad.mit.edu	37	chr16	23387159	23387159	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggagaaatactgcaacaaccGggacttcccagactggggtg	13	10	0	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr16:23387159G>A	uc002dln.2	+	8	1429	c.1253G>A	c.(1252-1254)CGG>CAG	p.R418Q		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	418	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	TGCAACAACCGGGACTTCCCA	0.612													A	23387159	A	A	23387159	3	1	281	1	0	0	0	0	1	0	0	0	13928	1116	39	2	1279	2	SCNN1B	16	23387159	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08	2735376	23387159	66967594	46	20220											
PKD1L2	114780	broad.mit.edu	37	chr16	81181775	81181775	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcctcaggtgtcagaaggccGtcctccatgggctgtgggga	16	11	2	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr16:81181775G>A	uc002fgh.1	-	29	4941	c.4941C>T	c.(4939-4941)GAC>GAT	p.D1647D	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1647	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCAGAAGGCCGTCCTCCATGG	0.642													A	81181775	A	A	81181775	2	1	281	1	0	0	0	0	0	0	0	1	11965	1136	40	1		1	PKD1L2	16	81181775	Silent	SNP	G	TCGA-81-5910-01A-11D-1696-08	57794616	81181775	9172978	47	20221											
MTHFSD	64779	broad.mit.edu	37	chr16	86585659	86585659	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgcagcaccagcagccgaaCgccttccagtggtttatcag	10	14	1	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr16:86585659C>T	uc002fjn.2	-	3	268	c.217G>A	c.(217-219)GTT>ATT	p.V73I	MTHFSD_uc010voo.1_Missense_Mutation_p.V53I|MTHFSD_uc002fjo.2_Intron|MTHFSD_uc002fjm.2_Missense_Mutation_p.V72I|MTHFSD_uc010vop.1_5'UTR|MTHFSD_uc010voq.1_Intron|MTHFSD_uc010vor.1_Intron|MTHFSD_uc002fjp.2_Missense_Mutation_p.V53I	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	73					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						AGCAGCCGAACGCCTTCCAGT	0.537													T	86585659	T	T	86585659	3	4	281	1	0	0	0	0	1	0	0	0	9933	536	19	1	958	1	MTHFSD	16	86585659	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08	5403884	86585659	3769094	48	20222											
GLP2R	9340	broad.mit.edu	37	chr17	9783793	9783793	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	agttgaaggatttgcaaaacTtatacgacttttcattcagt	7	6	2	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr17:9783793T>G	uc002gmd.1	+	11	1244	c.1244T>G	c.(1243-1245)CTT>CGT	p.L415R		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	415	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	TTTGCAAAACTTATACGACTT	0.393													G	9783793	G	G	9783793	3	3	281	1	0	0	0	0	1	0	0	0	6453	1609	56	5	1286	5	GLP2R	17	9783793	Missense_Mutation	SNP	T	TCGA-81-5910-01A-11D-1696-08		9783793	71411417	49	20223											
PRKCA	5578	broad.mit.edu	37	chr17	64299034	64299034	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cgtggccaaccgcttcgcccGcaaaggggcgctgaggcaga	15	14	0	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr17:64299034G>A	uc002jfp.1	+	1	109	c.65G>A	c.(64-66)CGC>CAC	p.R22H	PRKCA_uc002jfo.1_5'UTR	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	22					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	CGCTTCGCCCGCAAAGGGGCG	0.642													A	64299034	A	A	64299034	3	1	281	1	0	0	0	0	1	0	0	0	12507	1087	38	1	67	1	PRKCA	17	64299034	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08	54515241	64299034	16896176	50	20224											
LAMA1	284217	broad.mit.edu	37	chr18	6956725	6956725	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agccagcaggtgtccaggtcGacttgctcatggccaactgc	12	13	1	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr18:6956725G>A	uc002knm.2	-	56	8098	c.8004C>T	c.(8002-8004)GTC>GTT	p.V2668V	LAMA1_uc002knk.2_5'Flank|LAMA1_uc002knl.2_Silent_p.V121V|LAMA1_uc010wzj.1_Silent_p.V2144V	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2668	Laminin G-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTCCAGGTCGACTTGCTCAT	0.512													A	6956725	A	A	6956725	2	1	281	1	0	0	0	0	0	0	0	1	8605	1045	37	2		2	LAMA1	18	6956725	Silent	SNP	G	TCGA-81-5910-01A-11D-1696-08		6956725	71120523	51	20225											
SETBP1	26040	broad.mit.edu	37	chr18	42532158	42532158	+	Silent	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ctgcaaaaccgcgatgacctCcagtttctggcagacctgga	10	13	1	2			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr18:42532158C>T	uc010dni.2	+	4	3149	c.2853C>T	c.(2851-2853)CTC>CTT	p.L951L		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	951						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCGATGACCTCCAGTTTCTGG	0.502									Schinzel-Giedion_syndrome				T	42532158	T	T	42532158	2	4	281	1	0	0	0	0	0	0	0	1	14129	842	30	3		3	SETBP1	18	42532158	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08	35575433	42532158	35545090	52	20226											
FBN3	84467	broad.mit.edu	37	chr19	8130913	8130913	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtggctcaccacctccagccGgtaggttccaggccccggcc	12	18	1	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr19:8130913G>A	uc002mjf.2	-	63	8341	c.8320C>T	c.(8320-8322)CGG>TGG	p.R2774W	FBN3_uc002mje.2_Missense_Mutation_p.R570W	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2774						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						ACCTCCAGCCGGTAGGTTCCA	0.677													A	8130913	A	A	8130913	3	1	281	1	0	0	0	0	1	0	0	0	5704	1115	39	2	113	2	FBN3	19	8130913	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08		8130913	50998070	53	20227											
ZNF536	9745	broad.mit.edu	37	chr19	30934790	30934790	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacttgcagcagttcctcaaCgggcagaacctgggcatcat	11	12	2	1	rs144245375		TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr19:30934790C>T	uc002nsu.1	+	2	459	c.321C>T	c.(319-321)AAC>AAT	p.N107N	ZNF536_uc010edd.1_Silent_p.N107N	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AGTTCCTCAACGGGCAGAACC	0.652													T	30934790	T	T	30934790	2	4	281	1	0	0	0	0	0	0	0	1	17971	535	19	1		1	ZNF536	19	30934790	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08	22803877	30934790	28194193	54	20228											
PDCD2L	84306	broad.mit.edu	37	chr19	34895691	34895691	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cacgtgttcgcgtgcgcctgCcccggctgtagcaccggcgg	15	16	0	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr19:34895691C>T	uc002nvj.2	+	2	279	c.246C>T	c.(244-246)TGC>TGT	p.C82C		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	82						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CGTGCGCCTGCCCCGGCTGTA	0.721													T	34895691	T	T	34895691	2	4	281	1	0	0	0	0	0	0	0	1	11620	747	26	3		3	PDCD2L	19	34895691	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08	3960901	34895691	24233292	55	20229											
RYR1	6261	broad.mit.edu	37	chr19	38990276	38990276	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tccccatgcgggtggccaggCgagagcgtggaggagaacgc	18	11	0	2	rs138617219		TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr19:38990276C>T	uc002oit.2	+	44	7159	c.7029C>T	c.(7027-7029)GGC>GGT	p.G2343G	RYR1_uc002oiu.2_Silent_p.G2343G|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2343	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGTGGCCAGGCGAGAGCGTGG	0.667													T	38990276	T	T	38990276	2	4	281	1	0	0	0	0	0	0	0	1	13768	782	27	1		1	RYR1	19	38990276	Silent	SNP	C	TCGA-81-5910-01A-11D-1696-08	4094585	38990276	20138707	56	20230											
NLRP12	91662	broad.mit.edu	37	chr19	54312898	54312898	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tcgcgcggtcttccccgtccGcgctgtaggtggcgccatac	13	16	1	0			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr19:54312898G>A	uc002qch.3	-	3	2235	c.2015C>T	c.(2014-2016)GCG>GTG	p.A672V	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.A672V|NLRP12_uc002qcj.3_Missense_Mutation_p.A672V|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.A672V	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	672					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TTCCCCGTCCGCGCTGTAGGT	0.622													A	54312898	A	A	54312898	3	1	281	1	0	0	0	0	1	0	0	0	10474	1087	38	1	1298	1	NLRP12	19	54312898	Missense_Mutation	SNP	G	TCGA-81-5910-01A-11D-1696-08	15322622	54312898	4816085	57	20231											
MYH9	4627	broad.mit.edu	37	chr22	36714329	36714329	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	gaggattcctctggtgaaatCggtcacattgatacccaaga	10	9	2	3			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr22:36714329C>T	uc003apg.2	-	11	1381	c.1150G>A	c.(1150-1152)GAT>AAT	p.D384N	MYH9_uc003aph.1_Missense_Mutation_p.D248N	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	384	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CTGGTGAAATCGGTCACATTG	0.502			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				T	36714329	T	T	36714329	3	4	281	1	0	0	0	0	1	0	0	0	10042	884	31	2	4856	2	MYH9	22	36714329	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08		36714329	14590237	58	20232											
CELSR1	9620	broad.mit.edu	37	chr22	46829324	46829324	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcacctgcacagagtgccacCgcccgtcactcacaccactg	8	19	2	1			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chr22:46829324C>T	uc003bhw.1	-	5	4577	c.4577G>A	c.(4576-4578)CGG>CAG	p.R1526Q		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1526	Extracellular (Potential).|Laminin G-like 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGAGTGCCACCGCCCGTCACT	0.612													T	46829324	T	T	46829324	3	4	281	1	0	0	0	0	1	0	0	0	3221	652	23	2	4591	2	CELSR1	22	46829324	Missense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08	10114995	46829324	4475242	59	20233											
STAG2	10735	broad.mit.edu	37	chrX	123171416	123171416	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tagaatcatacaagcatgacCgagatatagcacttcttgac	7	9	2	4			TCGA-81-5910-01A-11D-1696-08	TCGA-81-5910-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	bcf79a66-30e6-4554-982e-38d8eab46114	ea0956e4-5094-419f-b786-95d4160723f4	g.chrX:123171416C>T	uc004etz.3	+	5	667	c.328C>T	c.(328-330)CGA>TGA	p.R110*	STAG2_uc004eua.2_Nonsense_Mutation_p.R110*|STAG2_uc004eub.2_Nonsense_Mutation_p.R110*|STAG2_uc004euc.2_Nonsense_Mutation_p.R110*|STAG2_uc004eud.2_Nonsense_Mutation_p.R110*|STAG2_uc004eue.2_Nonsense_Mutation_p.R110*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	110					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CAAGCATGACCGAGATATAGC	0.323													T	123171416	T	T	123171416	4	4	281	1	0	0	0	0	0	1	0	0	15242	644	23	2	342	2	STAG2	23	123171416	Nonsense_Mutation	SNP	C	TCGA-81-5910-01A-11D-1696-08		123171416	32099144	60	20234											
THAP3	90326	broad.mit.edu	37	chr1	6692962	6692962	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atctgatcacagctatgcccTtttggacttagattccctga	7	11	2	3			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr1:6692962T>C	uc001aoc.2	+	6	704	c.545T>C	c.(544-546)CTT>CCT	p.L182P	THAP3_uc001aod.2_Missense_Mutation_p.L181P|THAP3_uc001aoe.1_Intron			Q8WTV1	THAP3_HUMAN	RecName: Full=THAP domain-containing protein 3;	182							DNA binding|metal ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		AGCTATGCCCTTTTGGACTTA	0.567													C	6692962	C	C	6692962	3	2	282	1	0	0	0	0	1	0	0	0	15842	1624	56	4		4	THAP3	1	6692962	Missense_Mutation	SNP	T	TCGA-81-5911-01A-12D-1845-08		6692962	242557659	1	20235											
NOTCH2	4853	broad.mit.edu	37	chr1	120512286	120512286	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	atacacagccatagcctccaTtgcggttggcacaggtgccc	10	14	0	0	rs144936899		TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr1:120512286T>C	uc001eik.2	-	6	1212	c.956A>G	c.(955-957)AAT>AGT	p.N319S	NOTCH2_uc001eil.2_Missense_Mutation_p.N319S|NOTCH2_uc001eim.3_Missense_Mutation_p.N236S	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	319	Extracellular (Potential).|EGF-like 8; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAGCCTCCATTGCGGTTGGC	0.532			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				C	120512286	C	C	120512286	3	2	282	1	0	0	0	0	1	0	0	0	10548	1493	52	4	6575	4	NOTCH2	1	120512286	Missense_Mutation	SNP	T	TCGA-81-5911-01A-12D-1845-08	113819324	120512286	128738335	2	20236											
TCHH	7062	broad.mit.edu	37	chr1	152081317	152081317	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttcgcggaattttctgtgaCgctcctggcgcagctgctgt	12	12	1	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr1:152081317C>T	uc001ezp.2	-	2	4376	c.4376G>A	c.(4375-4377)CGT>CAT	p.R1459H	TCHH_uc009wne.1_Missense_Mutation_p.R1459H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1459	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTTCTGTGACGCTCCTGGCG	0.547													T	152081317	T	T	152081317	3	4	282	1	0	0	0	0	1	0	0	0	15697	536	19	1	1459	1	TCHH	1	152081317	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08	31569031	152081317	97169304	3	20237											
SOS1	6654	broad.mit.edu	37	chr2	39234297	39234297	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aataattcgactcaccacagCtactctttcttctaaatttt	2	11	4	0			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr2:39234297C>A	uc002rrk.3	-	16	2589	c.2548G>T	c.(2548-2550)GCT>TCT	p.A850S	SOS1_uc002rrj.3_Missense_Mutation_p.A464S	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	850	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				CTCACCACAGCTACTCTTTCT	0.323									Noonan_syndrome				A	39234297	A	A	39234297	3	1	282	1	0	0	0	0	1	0	0	0	14936	797	28	5	1485	5	SOS1	2	39234297	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08		39234297	203965076	4	20238											
IL1RL2	8808	broad.mit.edu	37	chr2	102805705	102805705	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagtctagaattcaccaggaCgagacttggattttgtttct	9	8	3	2			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr2:102805705C>T	uc002tbs.2	+	3	354	c.228C>T	c.(226-228)GAC>GAT	p.D76D	IL1RL2_uc002tbt.2_Intron	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	76	Extracellular (Potential).|Ig-like C2-type 1.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						TTCACCAGGACGAGACTTGGA	0.398													T	102805705	T	T	102805705	2	4	282	1	0	0	0	0	0	0	0	1	7664	535	19	1		1	IL1RL2	2	102805705	Silent	SNP	C	TCGA-81-5911-01A-12D-1845-08	63571408	102805705	140393668	5	20239											
PLEKHM3	389072	broad.mit.edu	37	chr2	208842070	208842070	+	Missense_Mutation	SNP	G	C	C	1	0	0	0	0	0	0	0	0	0	0	0	ctgcctttagctgtagctgaGtgttgtcatacaaaacagta	9	8	1	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr2:208842070G>C	uc002vcl.2	-	3	1341	c.851C>G	c.(850-852)ACT>AGT	p.T284S	PLEKHM3_uc002vcm.2_Missense_Mutation_p.T284S	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	284	PH 1.				intracellular signal transduction		metal ion binding			ovary(1)	1						CTGTAGCTGAGTGTTGTCATA	0.512													C	208842070	C	C	208842070	3	2	282	1	0	0	0	0	1	0	0	0	12082	1029	36	5	1458	5	PLEKHM3	2	208842070	Missense_Mutation	SNP	G	TCGA-81-5911-01A-12D-1845-08	106036365	208842070	34357303	6	20240											
CNTN6	27255	broad.mit.edu	37	chr3	1424680	1424680	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttggatatatcatcatgttcCggccagtgggctcgacaacc	10	11	2	0			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr3:1424680C>T	uc003boz.2	+	18	2488	c.2221C>T	c.(2221-2223)CGG>TGG	p.R741W	CNTN6_uc011asj.1_Missense_Mutation_p.R669W|CNTN6_uc003bpa.2_Missense_Mutation_p.R741W	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	741	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CATCATGTTCCGGCCAGTGGG	0.433													T	1424680	T	T	1424680	3	4	282	1	0	0	0	0	1	0	0	0	3645	643	23	2	2287	2	CNTN6	3	1424680	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08		1424680	196597750	7	20241											
FRAS1	80144	broad.mit.edu	37	chr4	79400817	79400817	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgctcattagtggtcccaaCgatgcctcgactgtgtccct	10	13	1	0			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr4:79400817C>T	uc003hlb.2	+	56	8828	c.8388C>T	c.(8386-8388)AAC>AAT	p.N2796N		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2791	Calx-beta 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GTGGTCCCAACGATGCCTCGA	0.532													T	79400817	T	T	79400817	2	4	282	1	0	0	0	0	0	0	0	1	6042	535	19	1		1	FRAS1	4	79400817	Silent	SNP	C	TCGA-81-5911-01A-12D-1845-08		79400817	111753459	8	20242											
SLC10A6	345274	broad.mit.edu	37	chr4	87749309	87749309	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagaaggaggaccccaccaaCaacggccccaatctgaagca	9	15	1	2			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr4:87749309C>T	uc003hqd.2	-	4	746	c.598G>A	c.(598-600)GTT>ATT	p.V200I		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	200	Helical; (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		ACCCCACCAACAACGGCCCCA	0.428													T	87749309	T	T	87749309	3	4	282	1	0	0	0	0	1	0	0	0	14378	478	17	3	547	3	SLC10A6	4	87749309	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08	8348492	87749309	103404967	9	20243											
RAMP3	10268	broad.mit.edu	37	chr7	45216936	45216936	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccagagcaggcggctgcaaCgagacaggcatgttggagag	16	10	0	3	rs145890722	byFrequency	TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr7:45216936C>T	uc003tnb.2	+	2	148	c.87C>T	c.(85-87)AAC>AAT	p.N29N	RAMP3_uc003tnc.2_Translation_Start_Site	NM_005856	NP_005847	O60896	RAMP3_HUMAN	receptor activity modifying protein 3 precursor	29	Extracellular (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity				0					Pramlintide(DB01278)	GCGGCTGCAACGAGACAGGCA	0.597													T	45216936	T	T	45216936	2	4	282	1	0	0	0	0	0	0	0	1	13023	535	19	1		1	RAMP3	7	45216936	Silent	SNP	C	TCGA-81-5911-01A-12D-1845-08		45216936	113921727	10	20244											
EGFR	1956	broad.mit.edu	37	chr7	55221822	55221822	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gggcaaatacagctttggtgCcacctgcgtgaagaagtgtc	13	9	0	2	rs149840192		TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr7:55221822C>T	uc003tqk.2	+	7	1112	c.866C>T	c.(865-867)GCC>GTC	p.A289V	EGFR_uc003tqh.2_Missense_Mutation_p.A289V|EGFR_uc003tqi.2_Missense_Mutation_p.A289V|EGFR_uc003tqj.2_Missense_Mutation_p.A289V|EGFR_uc010kzg.1_Missense_Mutation_p.A244V|EGFR_uc011kco.1_Missense_Mutation_p.A236V|EGFR_uc011kcp.1_5'Flank|EGFR_uc011kcq.1_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	289	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A289V(20)|p.V30_R297>G(5)|p.A289D(3)|p.A289T(3)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGCTTTGGTGCCACCTGCGTG	0.592		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			T	55221822	T	T	55221822	3	4	282	1	0	0	0	0	1	0	0	0	4967	739	26	3	892	3	EGFR	7	55221822	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08	10004886	55221822	103916841	11	20245											
DTX2	113878	broad.mit.edu	37	chr7	76112453	76112453	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccccaggatcctccacctcCggtgcagtcaggtatcgtgg	11	16	1	0			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr7:76112453C>T	uc003uff.3	+	5	1453	c.897C>T	c.(895-897)TCC>TCT	p.S299S	DTX2_uc011kgk.1_Silent_p.S208S|DTX2_uc003ufg.3_Silent_p.S299S|DTX2_uc003ufh.3_Silent_p.S299S|DTX2_uc003ufj.3_Silent_p.S299S	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	299					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CCTCCACCTCCGGTGCAGTCA	0.662													T	76112453	T	T	76112453	2	4	282	1	0	0	0	0	0	0	0	1	4794	639	23	2		2	DTX2	7	76112453	Silent	SNP	C	TCGA-81-5911-01A-12D-1845-08	20890631	76112453	83026210	12	20246											
OR2A2	442361	broad.mit.edu	37	chr7	143807297	143807297	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctgtgtgtttgtcttagtcGggcctctttccttgattctg	10	10	3	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr7:143807297G>A	uc011ktz.1	+	1	622	c.622G>A	c.(622-624)GGG>AGG	p.G208R		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TGTCTTAGTCGGGCCTCTTTC	0.522													A	143807297	A	A	143807297	3	1	282	1	0	0	0	0	1	0	0	0	10977	1116	39	2	624	2	OR2A2	7	143807297	Missense_Mutation	SNP	G	TCGA-81-5911-01A-12D-1845-08	67694844	143807297	15331366	13	20247											
CSMD3	114788	broad.mit.edu	37	chr8	114290824	114290824	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	ccactaccatcacttaccttCgtaatataccttaaatccat	1	14	1	0			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr8:114290824C>T	uc003ynu.2	-	3	670	c.511G>A	c.(511-513)GAA>AAA	p.E171K	CSMD3_uc003ynt.2_Missense_Mutation_p.E131K|CSMD3_uc011lhx.1_Missense_Mutation_p.E171K|CSMD3_uc010mcx.1_Missense_Mutation_p.E171K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	171	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACTTACCTTCGTAATATACC	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			T	114290824	T	T	114290824	3	4	282	1	0	0	0	0	1	0	0	0	3946	893	31	2	10888	2	CSMD3	8	114290824	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08		114290824	32073198	14	20248											
DENND3	22898	broad.mit.edu	37	chr8	142151330	142151330	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctgtttctacaatggcaaaaCgcaccgggagtgtcctggct	11	11	1	0			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr8:142151330C>T	uc003yvy.2	+	4	568	c.290C>T	c.(289-291)ACG>ATG	p.T97M	DENND3_uc003yvw.1_Missense_Mutation_p.T110M|DENND3_uc003yvx.2_Missense_Mutation_p.R176C|DENND3_uc010mep.2_Missense_Mutation_p.T110M	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	97										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			AATGGCAAAACGCACCGGGAG	0.532													T	142151330	T	T	142151330	3	4	282	1	0	0	0	0	1	0	0	0	4432	536	19	1	300	1	DENND3	8	142151330	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08	27860506	142151330	4212692	15	20249											
PTEN	5728	broad.mit.edu	37	chr10	89692923	89692923	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	acgaactggtgtaatgatatGtgcatatttattacatcggg	10	5	0	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr10:89692923G>A	uc001kfb.2	+	6	1438	c.407G>A	c.(406-408)TGT>TAT	p.C136Y		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	136	Phosphatase tensin-type.		C -> Y (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P3).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.C136Y(7)|p.R55fs*1(4)|p.C136F(3)|p.C136fs*1(2)|p.C136R(2)|p.?(2)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.I135_A137>T(1)|p.A121_F145del(1)|p.I135fs*6(1)|p.C136_A137insGM(1)|p.C136W(1)|p.T131fs*42(1)|p.F56fs*2(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GTAATGATATGTGCATATTTA	0.393		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			A	89692923	A	A	89692923	3	1	282	1	0	0	0	0	1	0	0	0	12738	1377	48	3	425	3	PTEN	10	89692923	Missense_Mutation	SNP	G	TCGA-81-5911-01A-12D-1845-08		89692923	45841824	16	20250											
OR4C11	219429	broad.mit.edu	37	chr11	55371120	55371120	+	Missense_Mutation	SNP	C	G	G	0	1	0	0	0	0	0	0	0	0	0	0	gccaaagaataagatgactaCaattatgtgagacgtgcaag	10	6	0	4			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr11:55371120C>G	uc010rii.1	-	1	730	c.730G>C	c.(730-732)GTA>CTA	p.V244L		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AAGATGACTACAATTATGTGA	0.408													G	55371120	G	G	55371120	3	3	282	1	0	0	0	0	1	0	0	0	11045	478	17	5	204	5	OR4C11	11	55371120	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08		55371120	79635396	17	20251											
OR5D13	390142	broad.mit.edu	37	chr11	55541619	55541619	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agatgcgatctgcaagtgggCgccagaaaactttctccacc	10	12	2	2			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr11:55541619C>T	uc010ril.1	+	1	706	c.706C>T	c.(706-708)CGC>TGC	p.R236C		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TGCAAGTGGGCGCCAGAAAAC	0.408													T	55541619	T	T	55541619	3	4	282	1	0	0	0	0	1	0	0	0	11154	768	27	1	708	1	OR5D13	11	55541619	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08	170499	55541619	79464897	18	20252											
OR5AS1	219447	broad.mit.edu	37	chr11	55798503	55798503	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cttctgctctttgctttgtgCagcttcatccagaccagcac	7	14	3	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr11:55798503C>T	uc010riw.1	+	1	609	c.609C>T	c.(607-609)TGC>TGT	p.C203C		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TTGCTTTGTGCAGCTTCATCC	0.423													T	55798503	T	T	55798503	2	4	282	1	0	0	0	0	0	0	0	1	11146	718	25	3		3	OR5AS1	11	55798503	Silent	SNP	C	TCGA-81-5911-01A-12D-1845-08	256884	55798503	79208013	19	20253											
FADS2	9415	broad.mit.edu	37	chr11	61615699	61615699	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aagcctaacatcttccacaaGgatcccgatgtgaacatgct	7	12	1	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr11:61615699G>A	uc001nsl.1	+	5	837	c.687G>A	c.(685-687)AAG>AAA	p.K229K	FADS2_uc001nsj.2_Silent_p.K207K|FADS2_uc010rlo.1_Silent_p.K198K|FADS2_uc001nsk.2_Silent_p.K229K	NM_004265	NP_004256	O95864	FADS2_HUMAN	fatty acid desaturase 2	229	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			ovary(1)|pancreas(1)	2					Alpha-Linolenic Acid(DB00132)	TCTTCCACAAGGATCCCGATG	0.557													A	61615699	A	A	61615699	2	1	282	1	0	0	0	0	0	0	0	1	5366	991	35	3		3	FADS2	11	61615699	Silent	SNP	G	TCGA-81-5911-01A-12D-1845-08	5817196	61615699	73390817	20	20254											
VEGFB	7423	broad.mit.edu	37	chr11	64004662	64004663	+	Frame_Shift_Ins	INS	-	A	A													ctatcttacttttcagacctINSaaaaaaaaggacagtgctgt							TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr11:64004662_64004663insA	uc001nyw.2	+	5	418_419	c.378_379insA	c.(376-381)CCTAAAfs	p.P126fs	VEGFB_uc001nyx.2_Frame_Shift_Ins_p.P126fs	NM_003377	NP_003368	P49765	VEGFB_HUMAN	vascular endothelial growth factor B precursor	126_127					anti-apoptosis|induction of positive chemotaxis|negative regulation of gene expression|negative regulation of neuron apoptosis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|vascular endothelial growth factor receptor signaling pathway	extracellular region|extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|heparin binding|vascular endothelial growth factor receptor 1 binding				0						TTTTCAGACCTAAAAAAAAGGA	0.386													A	64004663	A	A	64004662	7	5	282	1	0	1	1	0	0	0	0	0	17148	1509	53	0	396	0	VEGFB	11	64004662	Frame_Shift_Ins	INS	-	TCGA-81-5911-01A-12D-1845-08	2388963	64004662	71001854	21	20255											
CWF19L2	143884	broad.mit.edu	37	chr11	107224390	107224390	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcttcctcttcaccaagacGttctctctcagctgctttgg	6	15	5	1	rs146937549	by1000genomes	TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr11:107224390G>A	uc010rvp.1	-	13	1975	c.1945C>T	c.(1945-1947)CGT>TGT	p.R649C	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	649	Potential.						catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TCACCAAGACGTTCTCTCTCA	0.403													A	107224390	A	A	107224390	3	1	282	1	0	0	0	0	1	0	0	0	4072	1145	40	1	763	1	CWF19L2	11	107224390	Missense_Mutation	SNP	G	TCGA-81-5911-01A-12D-1845-08	43219728	107224390	27782126	22	20256											
CACNA1C	775	broad.mit.edu	37	chr12	2795380	2795380	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tctgaagcgacagaaggaccGagggggagacatctctcaga	14	9	3	4			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr12:2795380G>A	uc009zdu.1	+	48	6291	c.5978G>A	c.(5977-5979)CGA>CAA	p.R1993Q	CACNA1C_uc009zdv.1_Missense_Mutation_p.R1907Q|CACNA1C_uc001qkb.2_Missense_Mutation_p.R1910Q|CACNA1C_uc001qkc.2_Missense_Mutation_p.R1929Q|CACNA1C_uc001qke.2_Missense_Mutation_p.R1899Q|CACNA1C_uc001qkf.2_Missense_Mutation_p.R1918Q|CACNA1C_uc001qjz.2_Missense_Mutation_p.R1910Q|CACNA1C_uc001qkd.2_Missense_Mutation_p.R1929Q|CACNA1C_uc001qkg.2_Missense_Mutation_p.R1916Q|CACNA1C_uc009zdw.1_Missense_Mutation_p.R1951Q|CACNA1C_uc001qkh.2_Missense_Mutation_p.R1918Q|CACNA1C_uc001qkl.2_Missense_Mutation_p.R1958Q|CACNA1C_uc001qkn.2_Missense_Mutation_p.R1910Q|CACNA1C_uc001qko.2_Missense_Mutation_p.R1930Q|CACNA1C_uc001qkp.2_Missense_Mutation_p.R1910Q|CACNA1C_uc001qkr.2_Missense_Mutation_p.R1927Q|CACNA1C_uc001qku.2_Missense_Mutation_p.R1945Q|CACNA1C_uc001qkq.2_Missense_Mutation_p.R1938Q|CACNA1C_uc001qks.2_Missense_Mutation_p.R1910Q|CACNA1C_uc001qkt.2_Missense_Mutation_p.R1929Q|CACNA1C_uc001qki.1_Missense_Mutation_p.R1717Q|CACNA1C_uc001qkj.1_Missense_Mutation_p.R1681Q|CACNA1C_uc001qkk.1_Missense_Mutation_p.R1646Q|CACNA1C_uc001qkm.1_Missense_Mutation_p.R1706Q|CACNA1C_uc010sea.1_Missense_Mutation_p.R601Q|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Missense_Mutation_p.R228Q	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1993	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CAGAAGGACCGAGGGGGAGAC	0.582													A	2795380	A	A	2795380	3	1	282	1	0	0	0	0	1	0	0	0	2540	1058	37	2	6616	2	CACNA1C	12	2795380	Missense_Mutation	SNP	G	TCGA-81-5911-01A-12D-1845-08		2795380	131056515	23	20257											
RB1	5925	broad.mit.edu	37	chr13	48934208	48934208	+	Nonsense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	tcatttcagttaatgctatgTgtccttgactattttattaa	5	6	2	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr13:48934208T>A	uc001vcb.2	+	7	829	c.663T>A	c.(661-663)TGT>TGA	p.C221*	RB1_uc010acs.1_RNA|RB1_uc010act.1_5'UTR	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	221					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAATGCTATGTGTCCTTGACT	0.289		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			A	48934208	A	A	48934208	4	1	282	1	0	0	0	0	0	1	0	0	13098	1702	59	5	689	5	RB1	13	48934208	Nonsense_Mutation	SNP	T	TCGA-81-5911-01A-12D-1845-08		48934208	66235670	24	20258											
C15orf42	90381	broad.mit.edu	37	chr15	90161424	90161424	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	1	0	0	0	0	0	0	0	tattggtgttgttgaagagtCccctgaaaaaggagatggtg	14	4	0	4			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr15:90161424C>A	uc002boe.2	+	17	3002	c.3002C>A	c.(3001-3003)TCC>TAC	p.S1001Y		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1001					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GTTGAAGAGTCCCCTGAAAAA	0.388													A	90161424	A	A	90161424	3	1	282	1	0	0	0	0	1	0	0	0	1796	855	30	5	3068	5	C15orf42	15	90161424	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08		90161424	12369968	25	20259											
ACSM2B	348158	broad.mit.edu	37	chr16	20554273	20554273	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctgggctgctgatcacagccGtctcaaccacagcagggtgc	12	14	2	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr16:20554273G>A	uc002dhj.3	-	13	1682	c.1472C>T	c.(1471-1473)ACG>ATG	p.T491M	ACSM2B_uc002dhk.3_Missense_Mutation_p.T491M|ACSM2B_uc010bwf.1_Missense_Mutation_p.T491M	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	491					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						GATCACAGCCGTCTCAACCAC	0.517													A	20554273	A	A	20554273	3	1	282	1	0	0	0	0	1	0	0	0	184	1145	40	1	273	1	ACSM2B	16	20554273	Missense_Mutation	SNP	G	TCGA-81-5911-01A-12D-1845-08		20554273	69800480	26	20260											
ATP2A3	489	broad.mit.edu	37	chr17	3851127	3851127	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ccacggccacacccaccgctTtgcccgatgtgatattggtg	10	15	0	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr17:3851127T>A	uc002fxb.1	-	8	804	c.653A>T	c.(652-654)AAA>ATA	p.K218I	ATP2A3_uc002fwx.1_Missense_Mutation_p.K218I|ATP2A3_uc002fwy.1_Missense_Mutation_p.K218I|ATP2A3_uc002fwz.1_Missense_Mutation_p.K218I|ATP2A3_uc002fxa.1_Missense_Mutation_p.K218I|ATP2A3_uc002fxc.1_Missense_Mutation_p.K218I|ATP2A3_uc002fxd.1_Missense_Mutation_p.K218I	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	218	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		ACCCACCGCTTTGCCCGATGT	0.682													A	3851127	A	A	3851127	3	1	282	1	0	0	0	0	1	0	0	0	1138	1841	64	5	2613	5	ATP2A3	17	3851127	Missense_Mutation	SNP	T	TCGA-81-5911-01A-12D-1845-08		3851127	77344083	27	20261											
ANKFN1	162282	broad.mit.edu	37	chr17	54450196	54450196	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	catgaaaacaggctttgagcAtgccagtgagtataagcaga	11	7	0	4			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr17:54450196A>T	uc002iun.1	+	6	835	c.800A>T	c.(799-801)CAT>CTT	p.H267L		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	267										large_intestine(1)|ovary(1)	2						GGCTTTGAGCATGCCAGTGAG	0.433													T	54450196	T	T	54450196	3	4	282	1	0	0	0	0	1	0	0	0	625	217	8	5	822	5	ANKFN1	17	54450196	Missense_Mutation	SNP	A	TCGA-81-5911-01A-12D-1845-08	50599069	54450196	26745014	28	20262											
CYB561	1534	broad.mit.edu	37	chr17	61514742	61514742	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	agatcaggcctatgaccatgCagagggggtgcgcgttgaac	15	9	1	4			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr17:61514742C>A	uc002jap.2	-	1	569	c.167G>T	c.(166-168)TGC>TTC	p.C56F	CYB561_uc002jaq.2_Missense_Mutation_p.C102F|CYB561_uc002jar.2_Missense_Mutation_p.C56F|CYB561_uc002jas.2_Missense_Mutation_p.C56F|CYB561_uc010ddt.2_Missense_Mutation_p.C56F|CYB561_uc002jat.2_Missense_Mutation_p.C56F|CYB561_uc010wpf.1_Missense_Mutation_p.C56F|CYB561_uc010wpg.1_Missense_Mutation_p.C27F	NM_001915	NP_001906	P49447	CY561_HUMAN	cytochrome b-561	56	Helical; (Potential).|Cytochrome b561.				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(1115;0.0689)		TATGACCATGCAGAGGGGGTG	0.647													A	61514742	A	A	61514742	3	1	282	1	0	0	0	0	1	0	0	0	4119	710	25	5	608	5	CYB561	17	61514742	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08	7064546	61514742	19680468	29	20263											
CCDC45	90799	broad.mit.edu	37	chr17	62532771	62532771	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acattcaaaagcaaagattaCgagacctaagaaactatgcc	6	9	1	3			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr17:62532771C>T	uc002jem.2	+	18	2180	c.2122C>T	c.(2122-2124)CGA>TGA	p.R708*	CCDC45_uc002jen.2_RNA|CCDC45_uc010wqb.1_Nonsense_Mutation_p.R544*	NM_138363	NP_612372	Q96GE4	CEP95_HUMAN	coiled-coil domain containing 45	708	Potential.					centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			GCAAAGATTACGAGACCTAAG	0.373													T	62532771	T	T	62532771	4	4	282	1	0	0	0	0	0	1	0	0	2816	528	19	1	2192	1	CCDC45	17	62532771	Nonsense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08	1018029	62532771	18662439	30	20264											
FPR2	2358	broad.mit.edu	37	chr19	52272612	52272612	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gatccacaaaaagggcatgaTtaaatccagccgtcccttac	7	12	0	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr19:52272612T>C	uc002pxr.2	+	2	746	c.701T>C	c.(700-702)ATT>ACT	p.I234T	FPR2_uc002pxs.3_Missense_Mutation_p.I234T|FPR2_uc010epf.2_Missense_Mutation_p.I234T	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	234	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						AAGGGCATGATTAAATCCAGC	0.507													C	52272612	C	C	52272612	3	2	282	1	0	0	0	0	1	0	0	0	6039	1493	52	4	703	4	FPR2	19	52272612	Missense_Mutation	SNP	T	TCGA-81-5911-01A-12D-1845-08		52272612	6856371	31	20265											
LILRA4	23547	broad.mit.edu	37	chr19	54848923	54848923	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cagattctctccgggggtcaCgacagggccctgcagggtca	14	13	3	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr19:54848923C>T	uc002qfj.2	-	5	757	c.700G>A	c.(700-702)GTG>ATG	p.V234M	LILRA4_uc002qfi.2_Missense_Mutation_p.V168M	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	234	Extracellular (Potential).|Ig-like C2-type 3.					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CCGGGGGTCACGACAGGGCCC	0.647													T	54848923	T	T	54848923	3	4	282	1	0	0	0	0	1	0	0	0	8787	536	19	1	815	1	LILRA4	19	54848923	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08	2576311	54848923	4280060	32	20266											
LAIR1	3903	broad.mit.edu	37	chr19	54872745	54872745	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	cccaaccgggccccggcacaCgaaagtcacatggctcccca	9	19	1	0			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr19:54872745C>T	uc002qfk.1	-	3	452	c.142G>A	c.(142-144)GTG>ATG	p.V48M	LAIR1_uc002qfl.1_Missense_Mutation_p.V48M|LAIR1_uc002qfm.1_Missense_Mutation_p.V47M|LAIR1_uc002qfn.1_Missense_Mutation_p.V47M|LAIR1_uc010yex.1_Missense_Mutation_p.V41M|LAIR1_uc002qfo.2_Missense_Mutation_p.V30M	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like	48	Extracellular (Potential).|Ig-like C2-type.					integral to membrane|plasma membrane	protein binding|receptor activity			ovary(4)	4	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		CCCCGGCACACGAAAGTCACA	0.567													T	54872745	T	T	54872745	3	4	282	1	0	0	0	0	1	0	0	0	8602	536	19	1	753	1	LAIR1	19	54872745	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08	23822	54872745	4256238	33	20267											
SIGLEC1	6614	broad.mit.edu	37	chr20	3682241	3682241	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtgaaggatgcccacaagtcCcgcctgggtctccaggaagg	14	12	1	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr20:3682241C>T	uc002wja.2	-	6	1276	c.1276G>A	c.(1276-1278)GGA>AGA	p.G426R	SIGLEC1_uc002wiz.3_Missense_Mutation_p.G426R	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	426	Ig-like C2-type 4.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CCCACAAGTCCCGCCTGGGTC	0.632													T	3682241	T	T	3682241	3	4	282	1	0	0	0	0	1	0	0	0	14305	632	22	3	3917	3	SIGLEC1	20	3682241	Missense_Mutation	SNP	C	TCGA-81-5911-01A-12D-1845-08		3682241	59343279	34	20268											
DNAJC28	54943	broad.mit.edu	37	chr21	34861310	34861310	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	taaataatgtcggtgttgggGtgttttatatttgaattttt	10	1	0	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chr21:34861310G>A	uc002yrv.2	-	2	840	c.391C>T	c.(391-393)CCC>TCC	p.P131S	DNAJC28_uc002yrw.2_Missense_Mutation_p.P131S	NM_017833	NP_060303	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	131							heat shock protein binding				0						CGGTGTTGGGGTGTTTTATAT	0.393													A	34861310	A	A	34861310	3	1	282	1	0	0	0	0	1	0	0	0	4646	1261	44	3	779	3	DNAJC28	21	34861310	Missense_Mutation	SNP	G	TCGA-81-5911-01A-12D-1845-08		34861310	13268585	35	20269											
TEX13B	56156	broad.mit.edu	37	chrX	107224904	107224904	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttcgggggatcttacggcatGgaagagcttccatctcagca	12	10	2	1			TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chrX:107224904G>A	uc004enn.1	-	2	547	c.454C>T	c.(454-456)CAT>TAT	p.H152Y		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	152										ovary(1)	1						CTTACGGCATGGAAGAGCTTC	0.597													A	107224904	A	A	107224904	3	1	282	1	0	0	0	0	1	0	0	0	15774	1348	47	3	492	3	TEX13B	23	107224904	Missense_Mutation	SNP	G	TCGA-81-5911-01A-12D-1845-08		107224904	48045656	36	20270											
PASD1	139135	broad.mit.edu	37	chrX	150817142	150817144	+	In_Frame_Del	DEL	GCT	-	-													aagccgtgtacgttgaacccGctgctgctgctgctgctgct							TCGA-81-5911-01A-12D-1845-08	TCGA-81-5911-10A-01D-1845-08									Somatic	Phase_I	Capture				Illumina GAIIx	a501e01b-249c-43cb-aee2-f355c3c697dd	c391bf4d-b3e8-4447-9654-50004779a2d6	g.chrX:150817142_150817144delGCT	uc004fev.3	+	9	1017_1019	c.685_687delGCT	c.(685-687)GCTdel	p.A236del		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	236	Poly-Ala.					nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.355													-	150817144	-	-	150817142	7	5	282	1	0	1	0	1	0	0	0	0	11471	1087	38	0	715	0	PASD1	23	150817142	In_Frame_Del	DEL	GCT	TCGA-81-5911-01A-12D-1845-08	43592238	150817142	4453418	37	20271											
KTI12	112970	broad.mit.edu	37	chr1	52498511	52498511	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggtcaagggccgggtaaacCgcaagtgctctgtggtacca	14	10	2	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr1:52498511C>T	uc001ctj.1	-	1	962	c.923G>A	c.(922-924)CGG>CAG	p.R308Q	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	308							ATP binding			central_nervous_system(2)	2						CCGGGTAAACCGCAAGTGCTC	0.552													T	52498511	T	T	52498511	3	4	283	1	0	0	0	0	1	0	0	0	8584	652	23	2	145	2	KTI12	1	52498511	Missense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08		52498511	196752110	1	20272											
CACHD1	57685	broad.mit.edu	37	chr1	65141094	65141094	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgttctgtagggggatttgaCgaaccttgtgcatggcagcc	14	8	1	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr1:65141094C>T	uc001dbo.1	+	20	2690	c.2585C>T	c.(2584-2586)ACG>ATG	p.T862M	CACHD1_uc001dbp.1_Missense_Mutation_p.T617M|CACHD1_uc001dbq.1_Missense_Mutation_p.T617M|CACHD1_uc010opa.1_Missense_Mutation_p.T106M	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	913	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						GGGGATTTGACGAACCTTGTG	0.463											OREG0013544	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	65141094	T	T	65141094	3	4	283	1	0	0	0	0	1	0	0	0	2537	536	19	1	2663	1	CACHD1	1	65141094	Missense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08	12642583	65141094	184109527	2	20273											
RPF1	80135	broad.mit.edu	37	chr1	84961638	84961638	+	Nonsense_Mutation	SNP	C	G	G	0	1	1	0	1	0	1	1	0	1	1	0	tacaacacggctgggtcattCaattggacgtatgtttgcat	10	8	2	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr1:84961638C>G	uc001djv.3	+	7	818	c.773C>G	c.(772-774)TCA>TGA	p.S258*		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	258	Brix.				rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						CTGGGTCATTCAATTGGACGT	0.373													G	84961638	G	G	84961638	4	3	283	1	0	0	0	0	0	1	0	0	13546	838	29	5	799	5	RPF1	1	84961638	Nonsense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08	19820544	84961638	164288983	3	20274											
ODF2L	57489	broad.mit.edu	37	chr1	86851250	86851250	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	ttgcttccaattcagtctttTcatttagaatgtcctgcttc	5	10	3	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr1:86851250T>A	uc001dll.1	-	3	477	c.137A>T	c.(136-138)GAA>GTA	p.E46V	ODF2L_uc001dlm.1_Missense_Mutation_p.E46V|ODF2L_uc001dln.2_Missense_Mutation_p.E46V|ODF2L_uc001dlo.2_Intron|ODF2L_uc001dlp.2_Missense_Mutation_p.E46V|ODF2L_uc010osg.1_Missense_Mutation_p.E46V|ODF2L_uc001dlq.1_Intron|ODF2L_uc009wcr.1_Intron	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	46	Potential.					centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		TTCAGTCTTTTCATTTAGAAT	0.343													A	86851250	A	A	86851250	3	1	283	1	0	0	0	0	1	0	0	0	10828	1783	62	5	2013	5	ODF2L	1	86851250	Missense_Mutation	SNP	T	TCGA-87-5896-01A-01D-1696-08	1889612	86851250	162399371	4	20275											
S100A7L2	645922	broad.mit.edu	37	chr1	153409549	153409549	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tgggatcactggcttcccccGgaacagggtgccactccatg	12	14	1	0	rs140750285		TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr1:153409549G>A	uc010pdx.1	-	3	402	c.324C>T	c.(322-324)TCC>TCT	p.S108S		NM_001045479	NP_001038944			S100 calcium binding protein A7-like 2											ovary(1)	1	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGCTTCCCCCGGAACAGGGTG	0.488													A	153409549	A	A	153409549	2	1	283	1	0	0	0	0	0	0	0	1	13785	1103	39	2		2	S100A7L2	1	153409549	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	66558299	153409549	95841072	5	20276											
ZP4	57829	broad.mit.edu	37	chr1	238048511	238048511	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctgtagggttcacaaagctgAaggtgaagatgctgaagcgc	14	7	1	4			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr1:238048511A>C	uc001hym.2	-	9	1265	c.1265T>G	c.(1264-1266)TTC>TGC	p.F422C	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	422	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CACAAAGCTGAAGGTGAAGAT	0.537													C	238048511	C	C	238048511	3	2	283	1	0	0	0	0	1	0	0	0	18215	246	9	5	373	5	ZP4	1	238048511	Missense_Mutation	SNP	A	TCGA-87-5896-01A-01D-1696-08	84638962	238048511	11202110	6	20277											
OR2G6	391211	broad.mit.edu	37	chr1	248685273	248685273	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	1	0	1	0	1	0	0	0	tgtggccatggggttgggctCgtctgagtgtattctcttgg	16	7	2	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr1:248685273C>T	uc001ien.1	+	1	326	c.326C>T	c.(325-327)TCG>TTG	p.S109L		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGGTTGGGCTCGTCTGAGTGT	0.547													T	248685273	T	T	248685273	3	4	283	1	0	0	0	0	1	0	0	0	11000	893	31	2	328	2	OR2G6	1	248685273	Missense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08	10636762	248685273	565348	7	20278											
TTC15	51112	broad.mit.edu	37	chr2	3392072	3392072	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gcctcggacttcttcgactcCtttactacctccgccttcat	5	17	2	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr2:3392072C>T	uc002qxm.1	+	2	884	c.678C>T	c.(676-678)TCC>TCT	p.S226S	TTC15_uc002qxn.1_Silent_p.S226S|TTC15_uc010ewm.1_Silent_p.S226S|TTC15_uc002qxl.1_Silent_p.S226S	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	226							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		TCTTCGACTCCTTTACTACCT	0.547													T	3392072	T	T	3392072	2	4	283	1	0	0	0	0	0	0	0	1	16679	668	24	3		3	TTC15	2	3392072	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08		3392072	239807301	8	20279											
MAP4K4	9448	broad.mit.edu	37	chr2	102440436	102440436	+	Missense_Mutation	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	gataaatatgctaaagaaatActctcatcacagaaacattg	5	7	2	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr2:102440436A>T	uc002tbg.2	+	4	282	c.227A>T	c.(226-228)TAC>TTC	p.Y76F	MAP4K4_uc002tbc.2_Missense_Mutation_p.Y76F|MAP4K4_uc002tbd.2_Missense_Mutation_p.Y76F|MAP4K4_uc002tbe.2_Missense_Mutation_p.Y76F|MAP4K4_uc002tbf.2_Missense_Mutation_p.Y76F|MAP4K4_uc010yvy.1_Missense_Mutation_p.Y76F|MAP4K4_uc002tbh.2_Missense_Mutation_p.Y76F|MAP4K4_uc002tbi.2_Missense_Mutation_p.Y76F|MAP4K4_uc010yvz.1_Missense_Mutation_p.Y56F|MAP4K4_uc010fiw.1_Intron|MAP4K4_uc002tbj.1_5'Flank	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	76	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CTAAAGAAATACTCTCATCAC	0.368													T	102440436	T	T	102440436	3	4	283	1	0	0	0	0	1	0	0	0	9262	391	14	5	241	5	MAP4K4	2	102440436	Missense_Mutation	SNP	A	TCGA-87-5896-01A-01D-1696-08	99048364	102440436	140758937	9	20280											
ST6GAL2	84620	broad.mit.edu	37	chr2	107460197	107460197	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gctgggtgggcgcggggcagCgcctggcgtgcgtccaggcc	21	13	0	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr2:107460197C>T	uc002tdq.2	-	2	356	c.237G>A	c.(235-237)GCG>GCA	p.A79A	ST6GAL2_uc002tdr.2_Silent_p.A79A|ST6GAL2_uc002tds.3_Silent_p.A79A	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	79	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity	p.A79V(1)		pancreas(6)|ovary(4)|skin(1)	11						CGCGGGGCAGCGCCTGGCGTG	0.657													T	107460197	T	T	107460197	2	4	283	1	0	0	0	0	0	0	0	1	15221	755	27	1		1	ST6GAL2	2	107460197	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08	5019761	107460197	135739176	10	20281											
GPR149	344758	broad.mit.edu	37	chr3	154139085	154139085	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cagagagggcgtggtgctgaTttctacttttatagcattga	12	6	1	3			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr3:154139085T>C	uc003faa.2	-	3	1466	c.1366A>G	c.(1366-1368)ATC>GTC	p.I456V		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	456	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GTGGTGCTGATTTCTACTTTT	0.393													C	154139085	C	C	154139085	3	2	283	1	0	0	0	0	1	0	0	0	6654	1493	52	4	837	4	GPR149	3	154139085	Missense_Mutation	SNP	T	TCGA-87-5896-01A-01D-1696-08		154139085	43883345	11	20282											
TNIK	23043	broad.mit.edu	37	chr3	170800078	170800078	+	Missense_Mutation	SNP	T	G	G	0	0	0	0	0	0	0	0	0	0	0	0	cattcagtccctctagcacaTccatctgctgaaatcgcctc	5	16	3	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr3:170800078T>G	uc003fhh.2	-	27	3620	c.3275A>C	c.(3274-3276)GAT>GCT	p.D1092A	TNIK_uc003fhi.2_Missense_Mutation_p.D1037A|TNIK_uc003fhj.2_Missense_Mutation_p.D1063A|TNIK_uc003fhk.2_Missense_Mutation_p.D1084A|TNIK_uc003fhl.2_Missense_Mutation_p.D1008A|TNIK_uc003fhm.2_Missense_Mutation_p.D1029A|TNIK_uc003fhn.2_Missense_Mutation_p.D1055A|TNIK_uc003fho.2_Missense_Mutation_p.D1000A|TNIK_uc003fhg.2_Missense_Mutation_p.D270A|TNIK_uc003fhp.2_Missense_Mutation_p.D24A	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1092	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CTCTAGCACATCCATCTGCTG	0.483													G	170800078	G	G	170800078	3	3	283	1	0	0	0	0	1	0	0	0	16310	1435	50	5	835	5	TNIK	3	170800078	Missense_Mutation	SNP	T	TCGA-87-5896-01A-01D-1696-08	16660993	170800078	27222352	12	20283											
FYB	2533	broad.mit.edu	37	chr5	39153687	39153687	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	agggaagttgttgagtaagaCgtctggcctttgctagtacc	13	7	1	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr5:39153687C>T	uc003jls.2	-	2	1222	c.1155G>A	c.(1153-1155)ACG>ACA	p.T385T	FYB_uc003jlt.2_Silent_p.T385T|FYB_uc003jlu.2_Silent_p.T385T|FYB_uc011cpl.1_Silent_p.T395T	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	385	Interaction with SKAP1.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TTGAGTAAGACGTCTGGCCTT	0.423													T	39153687	T	T	39153687	2	4	283	1	0	0	0	0	0	0	0	1	6124	523	19	1		1	FYB	5	39153687	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08		39153687	141761573	13	20284											
IQGAP2	10788	broad.mit.edu	37	chr5	75998408	75998408	+	Missense_Mutation	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	gatggaaaaggtgcaactcaAtattcaggtaagctgctgga	12	6	2	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr5:75998408A>G	uc003kek.2	+	35	4829	c.4607A>G	c.(4606-4608)AAT>AGT	p.N1536S	IQGAP2_uc011csv.1_Missense_Mutation_p.N1032S|IQGAP2_uc003kel.2_Missense_Mutation_p.N1032S	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1536					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GTGCAACTCAATATTCAGGTA	0.353													G	75998408	G	G	75998408	3	3	283	1	0	0	0	0	1	0	0	0	7815	101	4	4	4745	4	IQGAP2	5	75998408	Missense_Mutation	SNP	A	TCGA-87-5896-01A-01D-1696-08	36844721	75998408	104916852	14	20285											
CEP120	153241	broad.mit.edu	37	chr5	122754205	122754205	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttggacgtttggggaaatgCcgacctggagaaacagaata	13	6	0	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr5:122754205C>T	uc003ktk.2	-	3	136	c.54G>A	c.(52-54)CGG>CGA	p.R18R	CEP120_uc011cwq.1_5'UTR|CEP120_uc010jcz.1_5'UTR	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	18						centrosome				ovary(1)	1						TGGGGAAATGCCGACCTGGAG	0.353													T	122754205	T	T	122754205	2	4	283	1	0	0	0	0	0	0	0	1	3246	726	26	3		3	CEP120	5	122754205	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08	46755797	122754205	58161055	15	20286											
DSP	1832	broad.mit.edu	37	chr6	7565623	7565623	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tgagaggatggatcacctgcGacagctgcagaacatcattc	11	10	2	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr6:7565623G>A	uc003mxp.1	+	7	1088	c.809G>A	c.(808-810)CGA>CAA	p.R270Q	DSP_uc003mxq.1_Missense_Mutation_p.R270Q	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	270	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GATCACCTGCGACAGCTGCAG	0.502													A	7565623	A	A	7565623	3	1	283	1	0	0	0	0	1	0	0	0	4781	1058	37	2	835	2	DSP	6	7565623	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08		7565623	163549444	16	20287											
DNAH8	1769	broad.mit.edu	37	chr6	38957817	38957817	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtgagaagatgtttgaaccGtcattctgcttttatactgg	10	6	2	3	rs143472136	byFrequency	TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr6:38957817G>A	uc003ooe.1	+	86	13032	c.12432G>A	c.(12430-12432)CCG>CCA	p.P4144P		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGTTTGAACCGTCATTCTGCT	0.368													A	38957817	A	A	38957817	2	1	283	1	0	0	0	0	0	0	0	1	4607	1132	40	1		1	DNAH8	6	38957817	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	31392194	38957817	132157250	17	20288											
GSTA1	2938	broad.mit.edu	37	chr6	52658945	52658945	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tttcaaaggcagggaagtagCgattttttattttctctttg	9	5	2	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr6:52658945C>T	uc003paz.2	-	5	504	c.392G>A	c.(391-393)CGC>CAC	p.R131H		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	131	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	AGGGAAGTAGCGATTTTTTAT	0.438													T	52658945	T	T	52658945	3	4	283	1	0	0	0	0	1	0	0	0	6830	768	27	1	288	1	GSTA1	6	52658945	Missense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08	13701128	52658945	118456122	18	20289											
AKD1	221264	broad.mit.edu	37	chr6	109827537	109827537	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	agtgctatcttacctgctttTattctttccaggtatgtctg	7	9	3	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr6:109827537T>C	uc003ptn.2	-	35	4919	c.4842A>G	c.(4840-4842)ATA>ATG	p.I1614M	AKD1_uc011eas.1_Missense_Mutation_p.I13M	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1614					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						TACCTGCTTTTATTCTTTCCA	0.323													C	109827537	C	C	109827537	3	2	283	1	0	0	0	0	1	0	0	0	460	1744	61	4	921	4	AKD1	6	109827537	Missense_Mutation	SNP	T	TCGA-87-5896-01A-01D-1696-08	57168592	109827537	61287530	19	20290											
MIOS	54468	broad.mit.edu	37	chr7	7612689	7612689	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tgtctctttgttggcttccaCgagaccagaaacttctcctt	7	12	2	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr7:7612689C>T	uc003srf.2	+	4	891	c.583C>T	c.(583-585)CGA>TGA	p.R195*	MIOS_uc010ktp.1_Nonsense_Mutation_p.R195*	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	195	WD 3.										0						TTGGCTTCCACGAGACCAGAA	0.383													T	7612689	T	T	7612689	4	4	283	1	0	0	0	0	0	1	0	0	9589	528	19	1	585	1	MIOS	7	7612689	Nonsense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08		7612689	151525974	20	20291											
ABCA13	154664	broad.mit.edu	37	chr7	48450229	48450229	+	Silent	SNP	G	T	T	1	0	0	1	0	1	0	0	0	0	0	0	tgcggtcctcccttctgcctGaaggaggcatatggccaggg	14	12	1	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr7:48450229G>T	uc003toq.2	+	40	12208	c.12183G>T	c.(12181-12183)CTG>CTT	p.L4061L	ABCA13_uc010kys.1_Silent_p.L1135L|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4061	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CCTTCTGCCTGAAGGAGGCAT	0.582													T	48450229	T	T	48450229	2	4	283	1	0	0	0	0	0	0	0	1	31	1277	45	5		5	ABCA13	7	48450229	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	40837540	48450229	110688434	21	20292											
POM121L12	285877	broad.mit.edu	37	chr7	53104048	53104048	+	Silent	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	aaaaatggagcggttgcttcCttcgtgcccaggccagggcc	13	12	0	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr7:53104048C>A	uc003tpz.2	+	1	700	c.684C>A	c.(682-684)TCC>TCA	p.S228S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	228											0						CGGTTGCTTCCTTCGTGCCCA	0.637													A	53104048	A	A	53104048	2	1	283	1	0	0	0	0	0	0	0	1	12241	668	24	5		5	POM121L12	7	53104048	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08	4653819	53104048	106034615	22	20293											
NSUN5	55695	broad.mit.edu	37	chr7	72717906	72717906	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	agggagcacgtggagtagacGagccgctgcagggaagggaa	19	7	0	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr7:72717906G>A	uc003txw.2	-	8	1098	c.1062C>T	c.(1060-1062)CTC>CTT	p.L354L	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Silent_p.L354L|NSUN5_uc003txx.2_Silent_p.L316L|NSUN5_uc011kev.1_Silent_p.L354L	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	354							methyltransferase activity				0		Lung NSC(55;0.163)				TGGAGTAGACGAGCCGCTGCA	0.677													A	72717906	A	A	72717906	2	1	283	1	0	0	0	0	0	0	0	1	10681	1045	37	2		2	NSUN5	7	72717906	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	19613858	72717906	86420757	23	20294											
EPHB6	2051	broad.mit.edu	37	chr7	142566033	142566033	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tacatcgacccctccacctaCgaggacccctgtcaggccat	7	18	1	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr7:142566033C>T	uc011kst.1	+	14	2740	c.1953C>T	c.(1951-1953)TAC>TAT	p.Y651Y	EPHB6_uc011ksu.1_Silent_p.Y651Y|EPHB6_uc003wbs.2_Silent_p.Y359Y|EPHB6_uc003wbt.2_Silent_p.Y125Y|EPHB6_uc003wbu.2_Silent_p.Y359Y|EPHB6_uc003wbv.2_Silent_p.Y35Y	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	651	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CCTCCACCTACGAGGACCCCT	0.577													T	142566033	T	T	142566033	2	4	283	1	0	0	0	0	0	0	0	1	5178	547	19	1		1	EPHB6	7	142566033	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08	69848127	142566033	16572630	24	20295											
FAM110B	90362	broad.mit.edu	37	chr8	59059474	59059474	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctcccctgcctcccaagcccAaaatcgcagccatcgcctcc	5	22	0	0	rs139483735		TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr8:59059474A>C	uc003xtj.1	+	5	1565	c.685A>C	c.(685-687)AAA>CAA	p.K229Q		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	229						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				TCCCAAGCCCAAAATCGCAGC	0.632													C	59059474	C	C	59059474	3	2	283	1	0	0	0	0	1	0	0	0	5397	131	5	5	687	5	FAM110B	8	59059474	Missense_Mutation	SNP	A	TCGA-87-5896-01A-01D-1696-08		59059474	87304548	25	20296											
MYBL1	4603	broad.mit.edu	37	chr8	67507922	67507922	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ttctgattttattccatcttGtaaatagccctcctgttcca	4	11	2	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr8:67507922G>A	uc003xwj.2	-	6	990	c.583C>T	c.(583-585)CAA>TAA	p.Q195*	MYBL1_uc003xwl.2_Nonsense_Mutation_p.Q195*|MYBL1_uc003xwk.2_Nonsense_Mutation_p.Q195*	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	195					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			ATTCCATCTTGTAAATAGCCC	0.343													A	67507922	A	A	67507922	4	1	283	1	0	0	0	0	0	1	0	0	10009	1386	48	3	1719	3	MYBL1	8	67507922	Nonsense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08	8448448	67507922	78856100	26	20297											
NOL8	55035	broad.mit.edu	37	chr9	95077750	95077750	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	tagcaacattttttttcatcGcaataatttcatctgtatct	3	8	4	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr9:95077750G>A	uc004arv.2	-	7	1494	c.1157C>T	c.(1156-1158)GCG>GTG	p.A386V	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.A318V	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	386					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TTTTTTCATCGCAATAATTTC	0.323													A	95077750	A	A	95077750	3	1	283	1	0	0	0	0	1	0	0	0	10527	1087	38	1	2390	1	NOL8	9	95077750	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08		95077750	46135681	27	20298											
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112687347	112687347	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ttttgttcctacagggtttcTccagtacggatggaggtaag	12	7	1	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr9:112687347T>C	uc004bei.2	+	5	571	c.379T>C	c.(379-381)TCC>CCC	p.S127P	PALM2_uc004bef.2_Missense_Mutation_p.S129P|PALM2_uc004beg.2_Missense_Mutation_p.S129P|PALM2_uc004beh.3_Missense_Mutation_p.S127P|PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.S127P|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.S127P|PALM2-AKAP2_uc004bel.1_5'UTR	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:Variant_position_missing_in_Q9Y2D5_after_alignment							enzyme binding	p.S127Y(1)		ovary(3)|central_nervous_system(2)|skin(1)	6						ACAGGGTTTCTCCAGTACGGA	0.463													C	112687347	C	C	112687347	3	2	283	1	0	0	0	0	1	0	0	0	11410	1551	54	4	397	4	PALM2-AKAP2	9	112687347	Missense_Mutation	SNP	T	TCGA-87-5896-01A-01D-1696-08	17609597	112687347	28526084	28	20299											
CEL	1056	broad.mit.edu	37	chr9	135945919	135945919	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ctaccccaaatgggtgggggCcgaccatgcagatgacattc	12	12	0	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr9:135945919C>T	uc010naa.1	+	10	1383	c.1367C>T	c.(1366-1368)GCC>GTC	p.A456V		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	453					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		TGGGTGGGGGCCGACCATGCA	0.607													T	135945919	T	T	135945919	3	4	283	1	0	0	0	0	1	0	0	0	3209	739	26	3	1405	3	CEL	9	135945919	Missense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08	23258572	135945919	5267512	29	20300											
ZNF37A	7587	broad.mit.edu	37	chr10	38407548	38407548	+	Missense_Mutation	SNP	T	C	C	0	0	0	0	0	0	0	0	0	0	0	0	tgttcaccagagaactcataTaagacagaaaccctatggat	7	9	2	3			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr10:38407548T>C	uc001izk.2	+	8	2288	c.1469T>C	c.(1468-1470)ATA>ACA	p.I490T	ZNF37A_uc001izl.2_Missense_Mutation_p.I490T|ZNF37A_uc001izm.2_Missense_Mutation_p.I490T	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	490						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						AGAACTCATATAAGACAGAAA	0.413													C	38407548	C	C	38407548	3	2	283	1	0	0	0	0	1	0	0	0	17869	1406	49	4	1483	4	ZNF37A	10	38407548	Missense_Mutation	SNP	T	TCGA-87-5896-01A-01D-1696-08		38407548	97127199	30	20301											
PGR	5241	broad.mit.edu	37	chr11	100999671	100999671	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	tggccgaaacttcaggcaagGtgtccgaggtctggctcccc	13	13	2	0	rs141862537		TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr11:100999671G>T	uc001pgh.2	-	1	874	c.131C>A	c.(130-132)ACC>AAC	p.T44N	PGR_uc001pgi.2_Missense_Mutation_p.T44N|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	44	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	TTCAGGCAAGGTGTCCGAGGT	0.692													T	100999671	T	T	100999671	3	4	283	1	0	0	0	0	1	0	0	0	11805	1261	44	5	2702	5	PGR	11	100999671	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08		100999671	34006845	31	20302											
COL2A1	1280	broad.mit.edu	37	chr12	48371798	48371798	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ggtctcactgctcacctctcGtccaggttcacctgcaggac	9	16	4	0	rs145684327		TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr12:48371798G>A	uc001rqu.2	-	44	3287	c.3106C>T	c.(3106-3108)CGA>TGA	p.R1036*	COL2A1_uc001rqt.2_5'Flank|COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Nonsense_Mutation_p.R967*	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	1036	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CTCACCTCTCGTCCAGGTTCA	0.662													A	48371798	A	A	48371798	4	1	283	1	0	0	0	0	0	1	0	0	3687	1153	40	1	1401	1	COL2A1	12	48371798	Nonsense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08		48371798	85480097	32	20303											
GLT8D2	83468	broad.mit.edu	37	chr12	104390580	104390580	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	agtcatctgagaaagccgccGcgtggcccagggccaaggtg	15	12	2	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr12:104390580G>A	uc001tkh.1	-	8	939	c.533C>T	c.(532-534)GCG>GTG	p.A178V	GLT8D2_uc001tki.1_Missense_Mutation_p.A178V	NM_031302	NP_112592	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	178	Lumenal (Potential).					integral to membrane	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2						GAAAGCCGCCGCGTGGCCCAG	0.483													A	104390580	A	A	104390580	3	1	283	1	0	0	0	0	1	0	0	0	6470	1087	38	1	532	1	GLT8D2	12	104390580	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08	56018782	104390580	29461315	33	20304											
CUX2	23316	broad.mit.edu	37	chr12	111772341	111772341	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gttgagcctgtccctggagaGcagcaaggagaaccagcagc	14	11	0	3			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr12:111772341G>A	uc001tsa.1	+	19	3176	c.3023G>A	c.(3022-3024)AGC>AAC	p.S1008N		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1008						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						TCCCTGGAGAGCAGCAAGGAG	0.647													A	111772341	A	A	111772341	3	1	283	1	0	0	0	0	1	0	0	0	4065	971	34	3	3097	3	CUX2	12	111772341	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08	7381761	111772341	22079554	34	20305											
ABCC4	10257	broad.mit.edu	37	chr13	95705392	95705392	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	cctcatccgtgtgctcattaAagggatccaggtttttcctc	8	12	2	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr13:95705392A>C	uc001vmd.3	-	27	3532	c.3413T>G	c.(3412-3414)TTT>TGT	p.F1138C	ABCC4_uc010afj.2_Missense_Mutation_p.F22C|ABCC4_uc010afk.2_Missense_Mutation_p.F1091C	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	1138	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	GTGCTCATTAAAGGGATCCAG	0.373													C	95705392	C	C	95705392	3	2	283	1	0	0	0	0	1	0	0	0	55	14	1	5	584	5	ABCC4	13	95705392	Missense_Mutation	SNP	A	TCGA-87-5896-01A-01D-1696-08		95705392	19464486	35	20306											
TEP1	7011	broad.mit.edu	37	chr14	20846241	20846241	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	catgcaggaaaagcgcagcaGcaacaaagccatggtgggca	13	10	0	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr14:20846241G>A	uc001vxe.2	-	39	5703	c.5663C>T	c.(5662-5664)GCT>GTT	p.A1888V	TEP1_uc010ahk.2_Missense_Mutation_p.A1231V|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.A1780V|TEP1_uc010tlh.1_Missense_Mutation_p.A226V	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1888	WD 7.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AAGCGCAGCAGCAACAAAGCC	0.632													A	20846241	A	A	20846241	3	1	283	1	0	0	0	0	1	0	0	0	15756	971	34	3	2288	3	TEP1	14	20846241	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08		20846241	86503299	36	20307											
MGAT2	4247	broad.mit.edu	37	chr14	50089072	50089072	+	Nonsense_Mutation	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tcttgtcttccaaaattctgGaaagtgctggttcctcaaat	7	9	4	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr14:50089072G>A	uc001wwr.2	+	1	1584	c.1086G>A	c.(1084-1086)TGG>TGA	p.W362*	SDCCAG1_uc010anj.1_Intron|RPL36AL_uc001wwq.1_5'Flank	NM_002408	NP_002399	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein	362	Lumenal (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity				0	all_epithelial(31;0.0021)|Breast(41;0.0124)					CAAAATTCTGGAAAGTGCTGG	0.423													A	50089072	A	A	50089072	4	1	283	1	0	0	0	0	0	1	0	0	9543	1183	41	3	1088	3	MGAT2	14	50089072	Nonsense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08	29242831	50089072	57260468	37	20308											
SFRS5	6430	broad.mit.edu	37	chr14	70237710	70237710	+	Splice_Site	SNP	A	T	T	0	0	0	0	0	0	0	0	0	0	0	0	aagtggctgttttccattttAgggtggttgagtttgcctct	12	6	1	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr14:70237710A>T	uc001xll.2	+	8	1892	c.441_splice	c.e8-2	p.G147_splice	SFRS5_uc001xlm.2_Splice_Site|SFRS5_uc001xlo.2_Splice_Site_p.G147_splice|SFRS5_uc001xlp.2_Splice_Site_p.G147_splice|SFRS5_uc001xlq.2_Splice_Site_p.G144_splice	NM_006925	NP_008856	Q13243	SRSF5_HUMAN	splicing factor, arginine/serine-rich 5						mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding				0				all cancers(60;0.00144)|BRCA - Breast invasive adenocarcinoma(234;0.0132)|OV - Ovarian serous cystadenocarcinoma(108;0.0154)		TTTCCATTTTAGGGTGGTTGA	0.348													T	70237710	T	T	70237710	5	4	283	1	0	0	0	0	0	0	1	0	14180	434	15	5	461	5	SFRS5	14	70237710	Splice_Site	SNP	A	TCGA-87-5896-01A-01D-1696-08	20148638	70237710	37111830	38	20309											
UBR1	197131	broad.mit.edu	37	chr15	43269028	43269028	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gctgcagatcaacagggtcaTcccaatacaaggatgggaat	11	9	2	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr15:43269028T>A	uc001zqq.2	-	39	4322	c.4256A>T	c.(4255-4257)GAT>GTT	p.D1419V		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1419					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AACAGGGTCATCCCAATACAA	0.388													A	43269028	A	A	43269028	3	1	283	1	0	0	0	0	1	0	0	0	16898	1435	50	5	1029	5	UBR1	15	43269028	Missense_Mutation	SNP	T	TCGA-87-5896-01A-01D-1696-08		43269028	59262364	39	20310											
EDC3	80153	broad.mit.edu	37	chr15	74925078	74925078	+	Missense_Mutation	SNP	C	A	A	0	1	0	0	0	0	0	0	0	0	0	0	gatacggcctgcgtgctcccCcagtggcagaggcaggccca	14	15	0	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr15:74925078C>A	uc002ayn.2	-	10	1890	c.1402G>T	c.(1402-1404)GGG>TGG	p.G468W	EDC3_uc002ayo.2_Missense_Mutation_p.G468W|EDC3_uc002aym.2_Missense_Mutation_p.G468W	NM_001142443	NP_001135915	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	468	YjeF N-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1						GCGTGCTCCCCCAGTGGCAGA	0.577											OREG0023286	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	A	74925078	A	A	74925078	3	1	283	1	0	0	0	0	1	0	0	0	4907	623	22	5	128	5	EDC3	15	74925078	Missense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08	31656050	74925078	27606314	40	20311											
CSPG4	1464	broad.mit.edu	37	chr15	75980829	75980829	+	Nonsense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	gaggcacgtgctgtggccccAtaggtcacccggccagcctg	14	15	1	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr15:75980829A>C	uc002baw.2	-	3	2670	c.2577T>G	c.(2575-2577)TAT>TAG	p.Y859*		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	859	CSPG 4.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CTGTGGCCCCATAGGTCACCC	0.577													C	75980829	C	C	75980829	4	2	283	1	0	0	0	0	0	1	0	0	3960	224	8	5	4423	5	CSPG4	15	75980829	Nonsense_Mutation	SNP	A	TCGA-87-5896-01A-01D-1696-08	1055751	75980829	26550563	41	20312											
C15orf42	90381	broad.mit.edu	37	chr15	90142688	90142688	+	Silent	SNP	A	G	G	0	0	0	0	0	0	0	0	0	0	0	0	aaaatgttcctaaaatcaaaAggcaccaaggaattagaagt	7	6	1	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr15:90142688A>G	uc002boe.2	+	8	2034	c.2034A>G	c.(2032-2034)AAA>AAG	p.K678K		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	678					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TAAAATCAAAAGGCACCAAGG	0.358													G	90142688	G	G	90142688	2	3	283	1	0	0	0	0	0	0	0	1	1796	69	3	4		4	C15orf42	15	90142688	Silent	SNP	A	TCGA-87-5896-01A-01D-1696-08	14161859	90142688	12388704	42	20313											
SPG7	6687	broad.mit.edu	37	chr16	89598461	89598461	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	atggccggcccagagttcgtGgaggtcattggaggtaggtg	18	7	1	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr16:89598461G>A	uc002fnj.2	+	8	1158	c.1137G>A	c.(1135-1137)GTG>GTA	p.V379V	SPG7_uc002fni.2_Silent_p.V379V	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	379	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		CAGAGTTCGTGGAGGTCATTG	0.647													A	89598461	A	A	89598461	2	1	283	1	0	0	0	0	0	0	0	1	15043	1335	47	3		3	SPG7	16	89598461	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08		89598461	756292	43	20314											
CCL2	6347	broad.mit.edu	37	chr17	32583358	32583358	+	Missense_Mutation	SNP	T	A	A	0	0	0	0	0	0	0	0	0	0	0	0	gtgtcccaaagaagctgtgaTgtgagttcagcacaccaacc	10	11	1	3			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr17:32583358T>A	uc002hhy.2	+	2	267	c.194T>A	c.(193-195)ATC>AAC	p.I65N		NM_002982	NP_002973	P13500	CCL2_HUMAN	small inducible cytokine A2 precursor	65				Missing: 90% reduction in activity.|Missing: 83% reduction in activity.	angiogenesis|anti-apoptosis|apoptotic cell clearance|astrocyte cell migration|cell adhesion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|G-protein signaling, coupled to cyclic nucleotide second messenger|helper T cell extravasation|humoral immune response|inflammatory response|JAK-STAT cascade|macrophage chemotaxis|monocyte chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of T cell activation|viral genome replication	extracellular space	CCR2 chemokine receptor binding|chemokine activity|protein kinase activity|signal transducer activity			pancreas(1)	1	Breast(3;0.00224)	Ovarian(249;0.0694)|Breast(31;0.151)|Lung NSC(157;0.153)		UCEC - Uterine corpus endometrioid carcinoma (308;0.000241)|BRCA - Breast invasive adenocarcinoma(366;0.0103)	Atorvastatin(DB01076)|Danazol(DB01406)|Mimosine(DB01055)|Simvastatin(DB00641)	GAAGCTGTGATGTGAGTTCAG	0.478													A	32583358	A	A	32583358	3	1	283	1	0	0	0	0	1	0	0	0	2891	1478	51	5	200	5	CCL2	17	32583358	Missense_Mutation	SNP	T	TCGA-87-5896-01A-01D-1696-08		32583358	48611852	44	20315											
TNS4	84951	broad.mit.edu	37	chr17	38641225	38641225	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	tatttagatgtgtccatcacGaacttcatggtgggctgcat	10	8	2	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr17:38641225G>A	uc010cxb.2	-	5	1487	c.1323C>T	c.(1321-1323)TTC>TTT	p.F441F		NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	441					apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			TGTCCATCACGAACTTCATGG	0.547													A	38641225	A	A	38641225	2	1	283	1	0	0	0	0	0	0	0	1	16342	1049	37	2		2	TNS4	17	38641225	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	6057867	38641225	42553985	45	20316											
KRT39	390792	broad.mit.edu	37	chr17	39116597	39116597	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acattccagccgggacttgaCgtccagcaggatctcgtatt	10	12	1	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr17:39116597C>T	uc002hvo.1	-	6	1189	c.1153G>A	c.(1153-1155)GTC>ATC	p.V385I	KRT39_uc010wfm.1_Missense_Mutation_p.V118I	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	385	Coil 2.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				CGGGACTTGACGTCCAGCAGG	0.493													T	39116597	T	T	39116597	3	4	283	1	0	0	0	0	1	0	0	0	8476	536	19	1	330	1	KRT39	17	39116597	Missense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08	475372	39116597	42078613	46	20317											
SGCA	6442	broad.mit.edu	37	chr17	48246591	48246591	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	accttggcaccccacttccgCgttgactggtgcaatgtgac	10	14	0	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr17:48246591C>T	uc002iqi.2	+	6	759	c.723C>T	c.(721-723)CGC>CGT	p.R241R	SGCA_uc010wmh.1_Silent_p.R139R|SGCA_uc002iqj.2_Intron|SGCA_uc010wmi.1_RNA|uc010dbn.1_5'Flank	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	241	Extracellular (Potential).				muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						CCCACTTCCGCGTTGACTGGT	0.662											OREG0024558	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	48246591	T	T	48246591	2	4	283	1	0	0	0	0	0	0	0	1	14199	755	27	1		1	SGCA	17	48246591	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08	9129994	48246591	32948619	47	20318											
EPX	8288	broad.mit.edu	37	chr17	56277732	56277732	+	Nonsense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggcagctctcaacatgcaaCgaagccgggaccacggcctt	11	14	1	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr17:56277732C>T	uc002ivq.2	+	10	1770	c.1684C>T	c.(1684-1686)CGA>TGA	p.R562*		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	562					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						CAACATGCAACGAAGCCGGGA	0.617											OREG0024608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	T	56277732	T	T	56277732	4	4	283	1	0	0	0	0	0	1	0	0	5200	528	19	1	1722	1	EPX	17	56277732	Nonsense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08	8031141	56277732	24917478	48	20319											
ENPP7	339221	broad.mit.edu	37	chr17	77711814	77711814	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	cctcgtgatgggactgctggGgaccgtgattcttctgtctg	14	10	3	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr17:77711814G>A	uc002jxa.2	+	5	1366	c.1346G>A	c.(1345-1347)GGG>GAG	p.G449E		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	449	Helical; (Potential).				negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGACTGCTGGGGACCGTGATT	0.632													A	77711814	A	A	77711814	3	1	283	1	0	0	0	0	1	0	0	0	5135	1232	43	3	1364	3	ENPP7	17	77711814	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08	21434082	77711814	3483396	49	20320											
LAMA1	284217	broad.mit.edu	37	chr18	6977852	6977852	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	aggttggcttgaatttccacGtctttgacttttcttccagc	8	10	2	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr18:6977852G>A	uc002knm.2	-	44	6313	c.6219C>T	c.(6217-6219)GAC>GAT	p.D2073D	LAMA1_uc010wzj.1_Silent_p.D1549D	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2073	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAATTTCCACGTCTTTGACTT	0.398													A	6977852	A	A	6977852	2	1	283	1	0	0	0	0	0	0	0	1	8605	1136	40	1		1	LAMA1	18	6977852	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08		6977852	71099396	50	20321											
POTEC	388468	broad.mit.edu	37	chr18	14542921	14542921	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgcccacgttgctcgtgccGctccccctgcagcaggggaa	13	16	0	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr18:14542921G>A	uc010dln.2	-	1	679	c.225C>T	c.(223-225)AGC>AGT	p.S75S	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	75										skin(3)	3						TGCTCGTGCCGCTCCCCCTGC	0.567													A	14542921	A	A	14542921	2	1	283	1	0	0	0	0	0	0	0	1	12262	1078	38	1		1	POTEC	18	14542921	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	7565069	14542921	63534327	51	20322											
SERPINB11	89778	broad.mit.edu	37	chr18	61387390	61387390	+	Splice_Site	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtccttttcagctaagtgagGtaagtattttattttcagac	8	6	2	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr18:61387390G>A	uc002ljk.3	+	7	680	c.618_splice	c.e7+1	p.E206_splice	SERPINB11_uc010xes.1_Splice_Site_p.E31_splice|SERPINB11_uc010dqd.2_Splice_Site_p.E92_splice|SERPINB11_uc002ljj.3_Splice_Site_p.E92_splice|SERPINB11_uc010dqe.2_Intron|SERPINB11_uc010dqf.2_Intron	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				GCTAAGTGAGGTAAGTATTTT	0.313													A	61387390	A	A	61387390	5	1	283	1	0	0	0	0	0	0	1	0	14098	1275	44	3	637	3	SERPINB11	18	61387390	Splice_Site	SNP	G	TCGA-87-5896-01A-01D-1696-08	46844469	61387390	16689858	52	20323											
PTPRS	5802	broad.mit.edu	37	chr19	5273496	5273496	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	tggactgtgatctccccaacCgagttctgggccacacactc	9	15	2	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr19:5273496C>T	uc002mbv.2	-	4	570	c.336G>A	c.(334-336)TCG>TCA	p.S112S	PTPRS_uc002mbu.1_Silent_p.S112S|PTPRS_uc010xin.1_Silent_p.S112S|PTPRS_uc002mbw.2_Silent_p.S112S|PTPRS_uc002mbx.2_Silent_p.S112S|PTPRS_uc002mby.2_Silent_p.S112S|PTPRS_uc002mbz.1_Silent_p.S112S	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	112	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TCTCCCCAACCGAGTTCTGGG	0.587													T	5273496	T	T	5273496	2	4	283	1	0	0	0	0	0	0	0	1	12811	639	23	2		2	PTPRS	19	5273496	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08		5273496	53855487	53	20324											
KRTDAP	388533	broad.mit.edu	37	chr19	35979579	35979579	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	ctcacagatcgcaatttgtcGatgttcaggaacggggtgtt	12	8	2	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr19:35979579G>A	uc002nzh.2	-	3	165	c.153C>T	c.(151-153)ATC>ATT	p.I51I		NM_207392	NP_997275	P60985	KTDAP_HUMAN	keratinocyte differentiation-associated protein	51					cell differentiation	extracellular region					0	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCAATTTGTCGATGTTCAGGA	0.512													A	35979579	A	A	35979579	2	1	283	1	0	0	0	0	0	0	0	1	8580	1048	37	2		2	KRTDAP	19	35979579	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	30706083	35979579	23149404	54	20325											
SIPA1L3	23094	broad.mit.edu	37	chr19	38621245	38621245	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	acggtggccgaggttgaggaCtatgggttcgcctggcaggc	18	9	0	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr19:38621245C>T	uc002ohk.2	+	10	3485	c.2976C>T	c.(2974-2976)GAC>GAT	p.D992D		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	992	PDZ.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGTTGAGGACTATGGGTTCG	0.662													T	38621245	T	T	38621245	2	4	283	1	0	0	0	0	0	0	0	1	14331	564	20	3		3	SIPA1L3	19	38621245	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08	2641666	38621245	20507738	55	20326											
LTBP4	8425	broad.mit.edu	37	chr19	41133127	41133127	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gacatgccagactttgaggaCgatggtggcccctatggcga	14	10	0	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr19:41133127C>T	uc002ooh.1	+	32	4434	c.4434C>T	c.(4432-4434)GAC>GAT	p.D1478D	LTBP4_uc002oog.1_Silent_p.D1441D|LTBP4_uc002ooi.1_Silent_p.D1411D|LTBP4_uc002ooj.1_Silent_p.D351D|LTBP4_uc002ook.1_Silent_p.D612D|LTBP4_uc002ool.1_Silent_p.D490D|LTBP4_uc010xvp.1_Silent_p.D238D	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1478	Pro-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACTTTGAGGACGATGGTGGCC	0.701													T	41133127	T	T	41133127	2	4	283	1	0	0	0	0	0	0	0	1	9076	535	19	1		1	LTBP4	19	41133127	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08	2511882	41133127	17995856	56	20327											
CEACAM3	1084	broad.mit.edu	37	chr19	42301582	42301582	+	Silent	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	ctcactattgaatccatgccGctcagtgtcgcagaggggaa	11	11	2	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr19:42301582G>A	uc002orn.1	+	2	202	c.126G>A	c.(124-126)CCG>CCA	p.P42P	CEACAM3_uc010eia.1_Silent_p.P42P|CEACAM3_uc002oro.1_RNA	NM_001815	NP_001806	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion	42	Ig-like V-type.|Extracellular (Potential).					integral to membrane				skin(1)	1						AATCCATGCCGCTCAGTGTCG	0.522													A	42301582	A	A	42301582	2	1	283	1	0	0	0	0	0	0	0	1	3193	1074	38	1		1	CEACAM3	19	42301582	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	1168455	42301582	16827401	57	20328											
PSG1	5669	broad.mit.edu	37	chr19	43383725	43383725	+	Silent	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	gtgcagggaggggctgagagGgttcccatggtctctgctgc	18	9	1	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chr19:43383725G>T	uc002ovb.2	-	1	147	c.9C>A	c.(7-9)ACC>ACA	p.T3T	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Silent_p.T3T|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Silent_p.T3T|PSG1_uc010eio.1_Silent_p.T3T|PSG1_uc002oux.1_5'Flank|PSG1_uc002ouy.1_Silent_p.T3T|PSG1_uc002ouz.1_Silent_p.T3T|PSG1_uc002ova.1_Silent_p.T3T|PSG1_uc002ovc.2_Silent_p.T3T|PSG1_uc002ovd.1_Silent_p.T3T	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	3					female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GGGCTGAGAGGGTTCCCATGG	0.572													T	43383725	T	T	43383725	2	4	283	1	0	0	0	0	0	0	0	1	12653	1219	43	5		5	PSG1	19	43383725	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	1082143	43383725	15745258	58	20329											
MAP7D2	256714	broad.mit.edu	37	chrX	20074865	20074865	+	Silent	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	ttctttttcagctccagctgCtgtgtgcgctccagggaccg	11	13	2	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chrX:20074865C>T	uc004czr.1	-	4	436	c.417G>A	c.(415-417)CAG>CAA	p.Q139Q	MAP7D2_uc004czq.1_Silent_p.Q10Q|MAP7D2_uc011mji.1_Silent_p.Q95Q|MAP7D2_uc010nfo.1_Silent_p.Q139Q|MAP7D2_uc011mjj.1_Silent_p.Q139Q|MAP7D2_uc004czs.1_Silent_p.Q95Q	NM_152780	NP_689993	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	139	Potential.									ovary(2)|breast(1)	3						GCTCCAGCTGCTGTGTGCGCT	0.557													T	20074865	T	T	20074865	2	4	283	1	0	0	0	0	0	0	0	1	9268	796	28	3		3	MAP7D2	23	20074865	Silent	SNP	C	TCGA-87-5896-01A-01D-1696-08		20074865	135195695	59	20330											
BCOR	54880	broad.mit.edu	37	chrX	39933293	39933293	+	Missense_Mutation	SNP	C	T	T	0	1	0	0	0	0	0	0	0	0	0	0	gtctagtggcttatctgtgaCgtctttggtaacggtctgct	12	8	4	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chrX:39933293C>T	uc004den.3	-	4	1598	c.1306G>A	c.(1306-1308)GTC>ATC	p.V436I	BCOR_uc004dep.3_Missense_Mutation_p.V436I|BCOR_uc004deo.3_Missense_Mutation_p.V436I|BCOR_uc004dem.3_Missense_Mutation_p.V436I|BCOR_uc004deq.3_Missense_Mutation_p.V436I	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	436					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TTATCTGTGACGTCTTTGGTA	0.527													T	39933293	T	T	39933293	3	4	283	1	0	0	0	0	1	0	0	0	1386	536	19	1	4009	1	BCOR	23	39933293	Missense_Mutation	SNP	C	TCGA-87-5896-01A-01D-1696-08	19858428	39933293	115337267	60	20331											
ITIH5L	347365	broad.mit.edu	37	chrX	54783873	54783873	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	ggggtttgaggcatatggggGtttggggtctcaggcttgga	20	4	1	1			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chrX:54783873G>T	uc004dtj.2	-	8	2664	c.2634C>A	c.(2632-2634)AAC>AAA	p.N878K		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	878	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GCATATGGGGGTTTGGGGTCT	0.483													T	54783873	T	T	54783873	3	4	283	1	0	0	0	0	1	0	0	0	7908	1252	44	5	1331	5	ITIH5L	23	54783873	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08	14850580	54783873	100486687	61	20332											
ZXDA	7789	broad.mit.edu	37	chrX	57935325	57935325	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	cagcctgccacaggacacacGaaaggctttgtgcccaggtg	12	13	0	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chrX:57935325G>A	uc004dve.2	-	1	1743	c.1530C>T	c.(1528-1530)TTC>TTT	p.F510F		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	510	Required for interaction with ZXDC.|C2H2-type 9.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CAGGACACACGAAAGGCTTTG	0.552													A	57935325	A	A	57935325	2	1	283	1	0	0	0	0	0	0	0	1	18247	1049	37	2		2	ZXDA	23	57935325	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	3151452	57935325	97335235	62	20333											
MAGT1	84061	broad.mit.edu	37	chrX	77112989	77112989	+	Missense_Mutation	SNP	G	T	T	1	0	0	0	0	0	0	0	0	0	0	0	aaagttggagctgaattcatGtttagctgaataaaaacgag	10	4	1	2			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chrX:77112989G>T	uc004fof.2	-	4	554	c.492C>A	c.(490-492)AAC>AAA	p.N164K	MAGT1_uc004fog.3_RNA	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	132					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						CTGAATTCATGTTTAGCTGAA	0.338													T	77112989	T	T	77112989	3	4	283	1	0	0	0	0	1	0	0	0	9196	1368	48	5	639	5	MAGT1	23	77112989	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08	19177664	77112989	78157571	63	20334											
RHOXF1	158800	broad.mit.edu	37	chrX	119243159	119243159	+	Silent	SNP	G	A	A	1	0	0	0	0	1	1	0	1	0	0	0	gcattctagggctagtccacGacgatgtagacacagtcgtc	11	11	1	1	rs145568775		TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chrX:119243159G>A	uc004esk.1	-	3	621	c.546C>T	c.(544-546)GTC>GTT	p.V182V	uc004esi.1_Intron	NM_139282	NP_644811	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	182					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCTAGTCCACGACGATGTAGA	0.507													A	119243159	A	A	119243159	2	1	283	1	0	0	0	0	0	0	0	1	13347	1045	37	2		2	RHOXF1	23	119243159	Silent	SNP	G	TCGA-87-5896-01A-01D-1696-08	42130170	119243159	36027401	64	20335											
RAP2C	57826	broad.mit.edu	37	chrX	131348336	131348336	+	Missense_Mutation	SNP	A	C	C	0	0	0	0	0	0	0	0	0	0	0	0	ctccatgaaaggacagccccAttcttgagccagagctctgc	9	14	2	3			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chrX:131348336A>C	uc004ewp.2	-	3	1196	c.412T>G	c.(412-414)TGG>GGG	p.W138G	RAP2C_uc004ewo.2_Missense_Mutation_p.W72G|RAP2C_uc010nrk.2_RNA|RAP2C_uc004ewq.3_Missense_Mutation_p.W138G	NM_021183	NP_067006	Q9Y3L5	RAP2C_HUMAN	RAP2C, member of RAS oncogene family precursor	138					negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GGACAGCCCCATTCTTGAGCC	0.438													C	131348336	C	C	131348336	3	2	283	1	0	0	0	0	1	0	0	0	13042	217	8	5	143	5	RAP2C	23	131348336	Missense_Mutation	SNP	A	TCGA-87-5896-01A-01D-1696-08	12105177	131348336	23922224	65	20336											
F9	2158	broad.mit.edu	37	chrX	138643011	138643011	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gtgttaaaattacagttgtcGcaggtaaatacacagaaaga	9	5	0	2	rs137852247		TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chrX:138643011G>A	uc004fas.1	+	7	864	c.835G>A	c.(835-837)GCA>ACA	p.A279T	F9_uc004fat.1_Missense_Mutation_p.A241T	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein	279	Peptidase S1.		A -> T (in HEMB; mild).		blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TACAGTTGTCGCAGGTAAATA	0.353													A	138643011	A	A	138643011	3	1	283	1	0	0	0	0	1	0	0	0	5351	1087	38	1	861	1	F9	23	138643011	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08	7294675	138643011	16627549	66	20337											
FATE1	89885	broad.mit.edu	37	chrX	150891145	150891145	+	Missense_Mutation	SNP	G	A	A	1	0	0	0	0	0	0	0	0	0	0	0	gcgccctggaggaacagggcGccacctggcgccacagggag	17	14	0	0			TCGA-87-5896-01A-01D-1696-08	TCGA-87-5896-10A-01D-1696-08									Somatic	Phase_I	Capture				Illumina GAIIx	640c33a6-a7df-4dba-9c21-367a9a839f0f	6de80c2c-8a7e-4ec4-9efa-9d43c101306b	g.chrX:150891145G>A	uc004fex.2	+	5	550	c.466G>A	c.(466-468)GCC>ACC	p.A156T		NM_033085	NP_149076	Q969F0	FATE1_HUMAN	fetal and adult testis expressed transcript	156						endoplasmic reticulum|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGAACAGGGCGCCACCTGGCG	0.652													A	150891145	A	A	150891145	3	1	283	1	0	0	0	0	1	0	0	0	5693	1087	38	1	484	1	FATE1	23	150891145	Missense_Mutation	SNP	G	TCGA-87-5896-01A-01D-1696-08	12248134	150891145	4379415	67	20338											
